id sid tid token lemma pos cord-010092-uftc8inx 1 1 key key NN cord-010092-uftc8inx 1 2 : : : cord-010092-uftc8inx 2 1 cord-010092-uftc8inx cord-010092-uftc8inx VBN cord-010092-uftc8inx 2 2 authors author NNS cord-010092-uftc8inx 2 3 : : : cord-010092-uftc8inx 2 4 nan nan NNP cord-010092-uftc8inx 2 5 title title NN cord-010092-uftc8inx 2 6 : : : cord-010092-uftc8inx 2 7 Abstract Abstract NNP cord-010092-uftc8inx 2 8 of of IN cord-010092-uftc8inx 2 9 29th 29th JJ cord-010092-uftc8inx 2 10 Regional Regional NNP cord-010092-uftc8inx 2 11 Congress Congress NNP cord-010092-uftc8inx 2 12 of of IN cord-010092-uftc8inx 2 13 the the DT cord-010092-uftc8inx 2 14 ISBT ISBT NNP cord-010092-uftc8inx 2 15 date date NN cord-010092-uftc8inx 2 16 : : : cord-010092-uftc8inx 2 17 2019 2019 CD cord-010092-uftc8inx 2 18 - - HYPH cord-010092-uftc8inx 2 19 06 06 CD cord-010092-uftc8inx 2 20 - - HYPH cord-010092-uftc8inx 2 21 07 07 CD cord-010092-uftc8inx 2 22 journal journal NN cord-010092-uftc8inx 2 23 : : : cord-010092-uftc8inx 2 24 Vox Vox NNP cord-010092-uftc8inx 2 25 Sang Sang NNP cord-010092-uftc8inx 2 26 DOI DOI NNP cord-010092-uftc8inx 2 27 : : : cord-010092-uftc8inx 3 1 10.1111 10.1111 CD cord-010092-uftc8inx 3 2 / / SYM cord-010092-uftc8inx 3 3 vox.12792 vox.12792 NNP cord-010092-uftc8inx 4 1 sha sha NNP cord-010092-uftc8inx 4 2 : : : cord-010092-uftc8inx 4 3 8255413c3d6cae0cd4a70c6000db8cc787837756 8255413c3d6cae0cd4a70c6000db8cc787837756 CD cord-010092-uftc8inx 4 4 doc_id doc_id CD cord-010092-uftc8inx 4 5 : : : cord-010092-uftc8inx 4 6 10092 10092 CD cord-010092-uftc8inx 4 7 cord_uid cord_uid NNS cord-010092-uftc8inx 4 8 : : : cord-010092-uftc8inx 5 1 uftc8inx uftc8inx JJ cord-010092-uftc8inx 5 2 nan nan NNP cord-010092-uftc8inx 5 3 in in IN cord-010092-uftc8inx 5 4 the the DT cord-010092-uftc8inx 5 5 fin fin FW cord-010092-uftc8inx 5 6 de de FW cord-010092-uftc8inx 5 7 siecle siecle FW cord-010092-uftc8inx 5 8 was be VBD cord-010092-uftc8inx 5 9 heavily heavily RB cord-010092-uftc8inx 5 10 concentrated concentrate VBN cord-010092-uftc8inx 5 11 in in IN cord-010092-uftc8inx 5 12 Vienna Vienna NNP cord-010092-uftc8inx 5 13 . . . cord-010092-uftc8inx 6 1 Freud Freud NNP cord-010092-uftc8inx 6 2 , , , cord-010092-uftc8inx 6 3 Boltzmann Boltzmann NNP cord-010092-uftc8inx 6 4 , , , cord-010092-uftc8inx 6 5 Schr€ Schr€ NNP cord-010092-uftc8inx 6 6 odinger odinger XX cord-010092-uftc8inx 6 7 and and CC cord-010092-uftc8inx 6 8 Mach Mach NNP cord-010092-uftc8inx 6 9 might may MD cord-010092-uftc8inx 6 10 be be VB cord-010092-uftc8inx 6 11 the the DT cord-010092-uftc8inx 6 12 first first JJ cord-010092-uftc8inx 6 13 names name NNS cord-010092-uftc8inx 6 14 to to TO cord-010092-uftc8inx 6 15 find find VB cord-010092-uftc8inx 6 16 , , , cord-010092-uftc8inx 6 17 whenever whenever WRB cord-010092-uftc8inx 6 18 one one PRP cord-010092-uftc8inx 6 19 cites cite VBZ cord-010092-uftc8inx 6 20 Austrian austrian JJ cord-010092-uftc8inx 6 21 scientists scientist NNS cord-010092-uftc8inx 6 22 . . . cord-010092-uftc8inx 7 1 But but CC cord-010092-uftc8inx 7 2 more more RBR cord-010092-uftc8inx 7 3 related related JJ cord-010092-uftc8inx 7 4 to to IN cord-010092-uftc8inx 7 5 transfusion transfusion NN cord-010092-uftc8inx 7 6 are be VBP cord-010092-uftc8inx 7 7 the the DT cord-010092-uftc8inx 7 8 Noble Noble NNP cord-010092-uftc8inx 7 9 Prize Prize NNP cord-010092-uftc8inx 7 10 winners winner NNS cord-010092-uftc8inx 7 11 Max Max NNP cord-010092-uftc8inx 7 12 Perutz Perutz NNP cord-010092-uftc8inx 7 13 and and CC cord-010092-uftc8inx 7 14 Karl Karl NNP cord-010092-uftc8inx 7 15 Landsteiner Landsteiner NNP cord-010092-uftc8inx 7 16 . . . cord-010092-uftc8inx 8 1 Landsteiner Landsteiner NNP cord-010092-uftc8inx 8 2 0 0 CD cord-010092-uftc8inx 8 3 s s NNP cord-010092-uftc8inx 8 4 fate fate NN cord-010092-uftc8inx 8 5 illustrates illustrate VBZ cord-010092-uftc8inx 8 6 the the DT cord-010092-uftc8inx 8 7 brain brain NN cord-010092-uftc8inx 8 8 drain drain NN cord-010092-uftc8inx 8 9 beginning begin VBG cord-010092-uftc8inx 8 10 in in IN cord-010092-uftc8inx 8 11 the the DT cord-010092-uftc8inx 8 12 early early JJ cord-010092-uftc8inx 8 13 30 30 CD cord-010092-uftc8inx 8 14 s s NN cord-010092-uftc8inx 8 15 escalating escalate VBG cord-010092-uftc8inx 8 16 in in IN cord-010092-uftc8inx 8 17 1939 1939 CD cord-010092-uftc8inx 8 18 with with IN cord-010092-uftc8inx 8 19 the the DT cord-010092-uftc8inx 8 20 " " `` cord-010092-uftc8inx 8 21 Anschluss Anschluss NNP cord-010092-uftc8inx 8 22 " " '' cord-010092-uftc8inx 8 23 , , , cord-010092-uftc8inx 8 24 which which WDT cord-010092-uftc8inx 8 25 lead lead VBP cord-010092-uftc8inx 8 26 to to IN cord-010092-uftc8inx 8 27 the the DT cord-010092-uftc8inx 8 28 forced force VBN cord-010092-uftc8inx 8 29 emigration emigration NN cord-010092-uftc8inx 8 30 of of IN cord-010092-uftc8inx 8 31 many many JJ cord-010092-uftc8inx 8 32 scientists scientist NNS cord-010092-uftc8inx 8 33 . . . cord-010092-uftc8inx 9 1 A a DT cord-010092-uftc8inx 9 2 loss loss NN cord-010092-uftc8inx 9 3 which which WDT cord-010092-uftc8inx 9 4 was be VBD cord-010092-uftc8inx 9 5 not not RB cord-010092-uftc8inx 9 6 regenerated regenerate VBN cord-010092-uftc8inx 9 7 in in IN cord-010092-uftc8inx 9 8 the the DT cord-010092-uftc8inx 9 9 post post JJ cord-010092-uftc8inx 9 10 war war NN cord-010092-uftc8inx 9 11 years year NNS cord-010092-uftc8inx 9 12 and and CC cord-010092-uftc8inx 9 13 was be VBD cord-010092-uftc8inx 9 14 further further RB cord-010092-uftc8inx 9 15 aggravated aggravate VBN cord-010092-uftc8inx 9 16 by by IN cord-010092-uftc8inx 9 17 dubious dubious JJ cord-010092-uftc8inx 9 18 and and CC cord-010092-uftc8inx 9 19 often often RB cord-010092-uftc8inx 9 20 undisclosed undisclosed JJ cord-010092-uftc8inx 9 21 relations relation NNS cord-010092-uftc8inx 9 22 and and CC cord-010092-uftc8inx 9 23 scandals scandal NNS cord-010092-uftc8inx 9 24 in in IN cord-010092-uftc8inx 9 25 the the DT cord-010092-uftc8inx 9 26 Nazi Nazi NNP cord-010092-uftc8inx 9 27 - - HYPH cord-010092-uftc8inx 9 28 era era NN cord-010092-uftc8inx 9 29 . . . cord-010092-uftc8inx 10 1 All all RB cord-010092-uftc8inx 10 2 together together RB cord-010092-uftc8inx 10 3 this this DT cord-010092-uftc8inx 10 4 leads lead VBZ cord-010092-uftc8inx 10 5 to to IN cord-010092-uftc8inx 10 6 a a DT cord-010092-uftc8inx 10 7 severe severe JJ cord-010092-uftc8inx 10 8 loss loss NN cord-010092-uftc8inx 10 9 of of IN cord-010092-uftc8inx 10 10 credibility credibility NN cord-010092-uftc8inx 10 11 and and CC cord-010092-uftc8inx 10 12 productivity productivity NN cord-010092-uftc8inx 10 13 of of IN cord-010092-uftc8inx 10 14 universities university NNS cord-010092-uftc8inx 10 15 across across IN cord-010092-uftc8inx 10 16 decades decade NNS cord-010092-uftc8inx 10 17 . . . cord-010092-uftc8inx 11 1 Opening open VBG cord-010092-uftc8inx 11 2 university university NN cord-010092-uftc8inx 11 3 access access NN cord-010092-uftc8inx 11 4 in in IN cord-010092-uftc8inx 11 5 the the DT cord-010092-uftc8inx 11 6 early early JJ cord-010092-uftc8inx 11 7 80 80 CD cord-010092-uftc8inx 11 8 s s NNS cord-010092-uftc8inx 11 9 and and CC cord-010092-uftc8inx 11 10 intensive intensive JJ cord-010092-uftc8inx 11 11 historical historical JJ cord-010092-uftc8inx 11 12 work work NN cord-010092-uftc8inx 11 13 - - HYPH cord-010092-uftc8inx 11 14 up up NN cord-010092-uftc8inx 11 15 of of IN cord-010092-uftc8inx 11 16 scandals scandal NNS cord-010092-uftc8inx 11 17 transformed transform VBD cord-010092-uftc8inx 11 18 the the DT cord-010092-uftc8inx 11 19 Austrian austrian JJ cord-010092-uftc8inx 11 20 universities university NNS cord-010092-uftc8inx 11 21 to to TO cord-010092-uftc8inx 11 22 open open VB cord-010092-uftc8inx 11 23 and and CC cord-010092-uftc8inx 11 24 effective effective JJ cord-010092-uftc8inx 11 25 scientific scientific JJ cord-010092-uftc8inx 11 26 institutions institution NNS cord-010092-uftc8inx 11 27 driving drive VBG cord-010092-uftc8inx 11 28 innovation innovation NN cord-010092-uftc8inx 11 29 in in IN cord-010092-uftc8inx 11 30 the the DT cord-010092-uftc8inx 11 31 country country NN cord-010092-uftc8inx 11 32 . . . cord-010092-uftc8inx 12 1 Austria Austria NNP cord-010092-uftc8inx 12 2 has have VBZ cord-010092-uftc8inx 12 3 achieved achieve VBN cord-010092-uftc8inx 12 4 a a DT cord-010092-uftc8inx 12 5 great great JJ cord-010092-uftc8inx 12 6 economic economic JJ cord-010092-uftc8inx 12 7 deal deal NN cord-010092-uftc8inx 12 8 in in IN cord-010092-uftc8inx 12 9 recent recent JJ cord-010092-uftc8inx 12 10 decades decade NNS cord-010092-uftc8inx 12 11 , , , cord-010092-uftc8inx 12 12 which which WDT cord-010092-uftc8inx 12 13 was be VBD cord-010092-uftc8inx 12 14 accelerated accelerate VBN cord-010092-uftc8inx 12 15 by by IN cord-010092-uftc8inx 12 16 the the DT cord-010092-uftc8inx 12 17 EU EU NNP cord-010092-uftc8inx 12 18 membership membership NN cord-010092-uftc8inx 12 19 in in IN cord-010092-uftc8inx 12 20 1995 1995 CD cord-010092-uftc8inx 12 21 . . . cord-010092-uftc8inx 13 1 As as IN cord-010092-uftc8inx 13 2 a a DT cord-010092-uftc8inx 13 3 result result NN cord-010092-uftc8inx 13 4 of of IN cord-010092-uftc8inx 13 5 strong strong JJ cord-010092-uftc8inx 13 6 long long JJ cord-010092-uftc8inx 13 7 - - HYPH cord-010092-uftc8inx 13 8 term term NN cord-010092-uftc8inx 13 9 economic economic JJ cord-010092-uftc8inx 13 10 performance performance NN cord-010092-uftc8inx 13 11 , , , cord-010092-uftc8inx 13 12 the the DT cord-010092-uftc8inx 13 13 country country NN cord-010092-uftc8inx 13 14 's 's POS cord-010092-uftc8inx 13 15 gross gross JJ cord-010092-uftc8inx 13 16 domestic domestic JJ cord-010092-uftc8inx 13 17 product product NN cord-010092-uftc8inx 13 18 ( ( -LRB- cord-010092-uftc8inx 13 19 GDP GDP NNP cord-010092-uftc8inx 13 20 ) ) -RRB- cord-010092-uftc8inx 13 21 per per IN cord-010092-uftc8inx 13 22 capita capita NN cord-010092-uftc8inx 13 23 is be VBZ cord-010092-uftc8inx 13 24 the the DT cord-010092-uftc8inx 13 25 eighth eighth JJ cord-010092-uftc8inx 13 26 highest high JJS cord-010092-uftc8inx 13 27 among among IN cord-010092-uftc8inx 13 28 OECD OECD NNP cord-010092-uftc8inx 13 29 countries country NNS cord-010092-uftc8inx 13 30 and and CC cord-010092-uftc8inx 13 31 fourth fourth JJ cord-010092-uftc8inx 13 32 in in IN cord-010092-uftc8inx 13 33 the the DT cord-010092-uftc8inx 13 34 EU28 EU28 NNP cord-010092-uftc8inx 13 35 . . . cord-010092-uftc8inx 14 1 Levels level NNS cord-010092-uftc8inx 14 2 of of IN cord-010092-uftc8inx 14 3 poverty poverty NN cord-010092-uftc8inx 14 4 and and CC cord-010092-uftc8inx 14 5 income income NN cord-010092-uftc8inx 14 6 inequality inequality NN cord-010092-uftc8inx 14 7 are be VBP cord-010092-uftc8inx 14 8 both both DT cord-010092-uftc8inx 14 9 below below IN cord-010092-uftc8inx 14 10 the the DT cord-010092-uftc8inx 14 11 OECD OECD NNP cord-010092-uftc8inx 14 12 average average NN cord-010092-uftc8inx 14 13 . . . cord-010092-uftc8inx 15 1 Investment investment NN cord-010092-uftc8inx 15 2 in in IN cord-010092-uftc8inx 15 3 research research NN cord-010092-uftc8inx 15 4 and and CC cord-010092-uftc8inx 15 5 development development NN cord-010092-uftc8inx 15 6 ( ( -LRB- cord-010092-uftc8inx 15 7 R&D r&d NN cord-010092-uftc8inx 15 8 ) ) -RRB- cord-010092-uftc8inx 15 9 increased increase VBD cord-010092-uftc8inx 15 10 since since IN cord-010092-uftc8inx 15 11 the the DT cord-010092-uftc8inx 15 12 EU EU NNP cord-010092-uftc8inx 15 13 accession accession NN cord-010092-uftc8inx 15 14 , , , cord-010092-uftc8inx 15 15 when when WRB cord-010092-uftc8inx 15 16 Austria Austria NNP cord-010092-uftc8inx 15 17 's 's POS cord-010092-uftc8inx 15 18 R&D r&d NN cord-010092-uftc8inx 15 19 intensity intensity NN cord-010092-uftc8inx 15 20 ( ( -LRB- cord-010092-uftc8inx 15 21 aggregate aggregate JJ cord-010092-uftc8inx 15 22 R&D r&d NN cord-010092-uftc8inx 15 23 expenditure expenditure NN cord-010092-uftc8inx 15 24 as as IN cord-010092-uftc8inx 15 25 a a DT cord-010092-uftc8inx 15 26 percentage percentage NN cord-010092-uftc8inx 15 27 of of IN cord-010092-uftc8inx 15 28 GDP gdp NN cord-010092-uftc8inx 15 29 ) ) -RRB- cord-010092-uftc8inx 15 30 was be VBD cord-010092-uftc8inx 15 31 well well RB cord-010092-uftc8inx 15 32 below below IN cord-010092-uftc8inx 15 33 the the DT cord-010092-uftc8inx 15 34 OECD OECD NNP cord-010092-uftc8inx 15 35 average average NN cord-010092-uftc8inx 15 36 and and CC cord-010092-uftc8inx 15 37 significantly significantly RB cord-010092-uftc8inx 15 38 far far RB cord-010092-uftc8inx 15 39 lower low JJR cord-010092-uftc8inx 15 40 than than IN cord-010092-uftc8inx 15 41 Switzerland Switzerland NNP cord-010092-uftc8inx 15 42 -a -a HYPH cord-010092-uftc8inx 15 43 country country NN cord-010092-uftc8inx 15 44 to to TO cord-010092-uftc8inx 15 45 which which WDT cord-010092-uftc8inx 15 46 Austria Austria NNP cord-010092-uftc8inx 15 47 prefers prefer VBZ cord-010092-uftc8inx 15 48 comparison comparison NN cord-010092-uftc8inx 15 49 . . . cord-010092-uftc8inx 16 1 The the DT cord-010092-uftc8inx 16 2 EU EU NNP cord-010092-uftc8inx 16 3 target target NN cord-010092-uftc8inx 16 4 of of IN cord-010092-uftc8inx 16 5 3 3 CD cord-010092-uftc8inx 16 6 % % NN cord-010092-uftc8inx 16 7 R&D r&d NN cord-010092-uftc8inx 16 8 intensity intensity NN cord-010092-uftc8inx 16 9 was be VBD cord-010092-uftc8inx 16 10 first first RB cord-010092-uftc8inx 16 11 met meet VBN cord-010092-uftc8inx 16 12 in in IN cord-010092-uftc8inx 16 13 2014 2014 CD cord-010092-uftc8inx 16 14 and and CC cord-010092-uftc8inx 16 15 is be VBZ cord-010092-uftc8inx 16 16 2018 2018 CD cord-010092-uftc8inx 16 17 the the DT cord-010092-uftc8inx 16 18 sixth sixth JJ cord-010092-uftc8inx 16 19 highest high JJS cord-010092-uftc8inx 16 20 among among IN cord-010092-uftc8inx 16 21 OECD OECD NNP cord-010092-uftc8inx 16 22 countries country NNS cord-010092-uftc8inx 16 23 and and CC cord-010092-uftc8inx 16 24 the the DT cord-010092-uftc8inx 16 25 second second JJ cord-010092-uftc8inx 16 26 highest high JJS cord-010092-uftc8inx 16 27 in in IN cord-010092-uftc8inx 16 28 the the DT cord-010092-uftc8inx 16 29 EU28 EU28 NNP cord-010092-uftc8inx 16 30 . . . cord-010092-uftc8inx 17 1 Austria Austria NNP cord-010092-uftc8inx 17 2 showed show VBD cord-010092-uftc8inx 17 3 the the DT cord-010092-uftc8inx 17 4 second second JJ cord-010092-uftc8inx 17 5 highest high JJS cord-010092-uftc8inx 17 6 increase increase NN cord-010092-uftc8inx 17 7 in in IN cord-010092-uftc8inx 17 8 R&D r&d NN cord-010092-uftc8inx 17 9 intensity intensity NN cord-010092-uftc8inx 17 10 of of IN cord-010092-uftc8inx 17 11 all all DT cord-010092-uftc8inx 17 12 OECD OECD NNP cord-010092-uftc8inx 17 13 countries country NNS cord-010092-uftc8inx 17 14 , , , cord-010092-uftc8inx 17 15 exceeded exceed VBD cord-010092-uftc8inx 17 16 only only RB cord-010092-uftc8inx 17 17 by by IN cord-010092-uftc8inx 17 18 Korea Korea NNP cord-010092-uftc8inx 17 19 . . . cord-010092-uftc8inx 18 1 The the DT cord-010092-uftc8inx 18 2 rapid rapid JJ cord-010092-uftc8inx 18 3 expansion expansion NN cord-010092-uftc8inx 18 4 was be VBD cord-010092-uftc8inx 18 5 matched match VBN cord-010092-uftc8inx 18 6 by by IN cord-010092-uftc8inx 18 7 a a DT cord-010092-uftc8inx 18 8 similar similar JJ cord-010092-uftc8inx 18 9 increase increase NN cord-010092-uftc8inx 18 10 in in IN cord-010092-uftc8inx 18 11 human human JJ cord-010092-uftc8inx 18 12 resources resource NNS cord-010092-uftc8inx 18 13 and and CC cord-010092-uftc8inx 18 14 scientific scientific JJ cord-010092-uftc8inx 18 15 output output NN cord-010092-uftc8inx 18 16 of of IN cord-010092-uftc8inx 18 17 universities university NNS cord-010092-uftc8inx 18 18 . . . cord-010092-uftc8inx 19 1 Austrian austrian JJ cord-010092-uftc8inx 19 2 science science NN cord-010092-uftc8inx 19 3 in in IN cord-010092-uftc8inx 19 4 quantum quantum NN cord-010092-uftc8inx 19 5 mechanics mechanic NNS cord-010092-uftc8inx 19 6 , , , cord-010092-uftc8inx 19 7 quantum quantum NN cord-010092-uftc8inx 19 8 communication communication NN cord-010092-uftc8inx 19 9 and and CC cord-010092-uftc8inx 19 10 information information NN cord-010092-uftc8inx 19 11 is be VBZ cord-010092-uftc8inx 19 12 world world NN cord-010092-uftc8inx 19 13 renown renown JJ cord-010092-uftc8inx 19 14 . . . cord-010092-uftc8inx 20 1 Vienna Vienna NNP cord-010092-uftc8inx 20 2 is be VBZ cord-010092-uftc8inx 20 3 a a DT cord-010092-uftc8inx 20 4 major major JJ cord-010092-uftc8inx 20 5 biotech biotech JJ cord-010092-uftc8inx 20 6 hub hub NN cord-010092-uftc8inx 20 7 , , , cord-010092-uftc8inx 20 8 as as IN cord-010092-uftc8inx 20 9 is be VBZ cord-010092-uftc8inx 20 10 Linz Linz NNP cord-010092-uftc8inx 20 11 in in IN cord-010092-uftc8inx 20 12 mathematics mathematic NNS cord-010092-uftc8inx 20 13 and and CC cord-010092-uftc8inx 20 14 mechatronics mechatronic NNS cord-010092-uftc8inx 20 15 and and CC cord-010092-uftc8inx 20 16 Graz Graz NNP cord-010092-uftc8inx 20 17 in in IN cord-010092-uftc8inx 20 18 automotive automotive JJ cord-010092-uftc8inx 20 19 and and CC cord-010092-uftc8inx 20 20 production production NN cord-010092-uftc8inx 20 21 technologies technology NNS cord-010092-uftc8inx 20 22 . . . cord-010092-uftc8inx 21 1 Austria Austria NNP cord-010092-uftc8inx 21 2 has have VBZ cord-010092-uftc8inx 21 3 been be VBN cord-010092-uftc8inx 21 4 a a DT cord-010092-uftc8inx 21 5 net net JJ cord-010092-uftc8inx 21 6 resource resource NN cord-010092-uftc8inx 21 7 recipient recipient NN cord-010092-uftc8inx 21 8 in in IN cord-010092-uftc8inx 21 9 the the DT cord-010092-uftc8inx 21 10 Horizon Horizon NNP cord-010092-uftc8inx 21 11 2020 2020 CD cord-010092-uftc8inx 21 12 and and CC cord-010092-uftc8inx 21 13 the the DT cord-010092-uftc8inx 21 14 preceding precede VBG cord-010092-uftc8inx 21 15 7th 7th NNP cord-010092-uftc8inx 21 16 Framework Framework NNP cord-010092-uftc8inx 21 17 Programme Programme NNP cord-010092-uftc8inx 21 18 . . . cord-010092-uftc8inx 22 1 Small small JJ cord-010092-uftc8inx 22 2 and and CC cord-010092-uftc8inx 22 3 mediumsized mediumsized JJ cord-010092-uftc8inx 22 4 enterprises enterprise NNS cord-010092-uftc8inx 22 5 show show VBP cord-010092-uftc8inx 22 6 a a DT cord-010092-uftc8inx 22 7 high high JJ cord-010092-uftc8inx 22 8 propensity propensity NN cord-010092-uftc8inx 22 9 to to TO cord-010092-uftc8inx 22 10 co co VB cord-010092-uftc8inx 22 11 - - VB cord-010092-uftc8inx 22 12 operate operate VB cord-010092-uftc8inx 22 13 with with IN cord-010092-uftc8inx 22 14 universities university NNS cord-010092-uftc8inx 22 15 and and CC cord-010092-uftc8inx 22 16 other other JJ cord-010092-uftc8inx 22 17 research research NN cord-010092-uftc8inx 22 18 organisations organisation NNS cord-010092-uftc8inx 22 19 and and CC cord-010092-uftc8inx 22 20 more more JJR cord-010092-uftc8inx 22 21 and and CC cord-010092-uftc8inx 22 22 more more RBR cord-010092-uftc8inx 22 23 included include VBN cord-010092-uftc8inx 22 24 in in IN cord-010092-uftc8inx 22 25 scientific scientific JJ cord-010092-uftc8inx 22 26 grant grant NN cord-010092-uftc8inx 22 27 schemes scheme NNS cord-010092-uftc8inx 22 28 . . . cord-010092-uftc8inx 23 1 Vienna Vienna NNP cord-010092-uftc8inx 23 2 is be VBZ cord-010092-uftc8inx 23 3 the the DT cord-010092-uftc8inx 23 4 largest large JJS cord-010092-uftc8inx 23 5 student student NN cord-010092-uftc8inx 23 6 city city NN cord-010092-uftc8inx 23 7 in in IN cord-010092-uftc8inx 23 8 the the DT cord-010092-uftc8inx 23 9 German German NNP cord-010092-uftc8inx 23 10 - - HYPH cord-010092-uftc8inx 23 11 speaking speak VBG cord-010092-uftc8inx 23 12 world world NN cord-010092-uftc8inx 23 13 and and CC cord-010092-uftc8inx 23 14 consistently consistently RB cord-010092-uftc8inx 23 15 ranks rank VBZ cord-010092-uftc8inx 23 16 among among IN cord-010092-uftc8inx 23 17 the the DT cord-010092-uftc8inx 23 18 top top JJ cord-010092-uftc8inx 23 19 cities city NNS cord-010092-uftc8inx 23 20 in in IN cord-010092-uftc8inx 23 21 the the DT cord-010092-uftc8inx 23 22 world world NN cord-010092-uftc8inx 23 23 on on IN cord-010092-uftc8inx 23 24 quality quality NN cord-010092-uftc8inx 23 25 - - HYPH cord-010092-uftc8inx 23 26 of of IN cord-010092-uftc8inx 23 27 - - HYPH cord-010092-uftc8inx 23 28 life life NN cord-010092-uftc8inx 23 29 indices index NNS cord-010092-uftc8inx 23 30 . . . cord-010092-uftc8inx 24 1 As as IN cord-010092-uftc8inx 24 2 Austria Austria NNP cord-010092-uftc8inx 24 3 possesses possess VBZ cord-010092-uftc8inx 24 4 globally globally RB cord-010092-uftc8inx 24 5 recognised recognise VBN cord-010092-uftc8inx 24 6 cultural cultural JJ cord-010092-uftc8inx 24 7 attractions attraction NNS cord-010092-uftc8inx 24 8 ranging range VBG cord-010092-uftc8inx 24 9 from from IN cord-010092-uftc8inx 24 10 famed famed JJ cord-010092-uftc8inx 24 11 Salzburg Salzburg NNP cord-010092-uftc8inx 24 12 festival festival NN cord-010092-uftc8inx 24 13 to to IN cord-010092-uftc8inx 24 14 the the DT cord-010092-uftc8inx 24 15 Vienna Vienna NNP cord-010092-uftc8inx 24 16 New New NNP cord-010092-uftc8inx 24 17 Year Year NNP cord-010092-uftc8inx 24 18 concert concert NN cord-010092-uftc8inx 24 19 its -PRON- PRP$ cord-010092-uftc8inx 24 20 inhabitants inhabitant NNS cord-010092-uftc8inx 24 21 are be VBP cord-010092-uftc8inx 24 22 not not RB cord-010092-uftc8inx 24 23 aware aware JJ cord-010092-uftc8inx 24 24 of of IN cord-010092-uftc8inx 24 25 the the DT cord-010092-uftc8inx 24 26 progress progress NN cord-010092-uftc8inx 24 27 made make VBN cord-010092-uftc8inx 24 28 in in IN cord-010092-uftc8inx 24 29 R&D r&d NN cord-010092-uftc8inx 24 30 and and CC cord-010092-uftc8inx 24 31 how how WRB cord-010092-uftc8inx 24 32 thriving thriving JJ cord-010092-uftc8inx 24 33 innovation innovation NN cord-010092-uftc8inx 24 34 is be VBZ cord-010092-uftc8inx 24 35 going go VBG cord-010092-uftc8inx 24 36 on on RP cord-010092-uftc8inx 24 37 in in IN cord-010092-uftc8inx 24 38 their -PRON- PRP$ cord-010092-uftc8inx 24 39 country country NN cord-010092-uftc8inx 24 40 . . . cord-010092-uftc8inx 25 1 They -PRON- PRP cord-010092-uftc8inx 25 2 still still RB cord-010092-uftc8inx 25 3 love love VBP cord-010092-uftc8inx 25 4 to to TO cord-010092-uftc8inx 25 5 show show VB cord-010092-uftc8inx 25 6 their -PRON- PRP$ cord-010092-uftc8inx 25 7 cultural cultural JJ cord-010092-uftc8inx 25 8 heritage heritage NN cord-010092-uftc8inx 25 9 and and CC cord-010092-uftc8inx 25 10 events event NNS cord-010092-uftc8inx 25 11 and and CC cord-010092-uftc8inx 25 12 impress impress VB cord-010092-uftc8inx 25 13 the the DT cord-010092-uftc8inx 25 14 world world NN cord-010092-uftc8inx 25 15 with with IN cord-010092-uftc8inx 25 16 some some DT cord-010092-uftc8inx 25 17 kind kind NN cord-010092-uftc8inx 25 18 of of IN cord-010092-uftc8inx 25 19 eternal eternal JJ cord-010092-uftc8inx 25 20 Sound sound NN cord-010092-uftc8inx 25 21 of of IN cord-010092-uftc8inx 25 22 Music Music NNP cord-010092-uftc8inx 25 23 . . . cord-010092-uftc8inx 26 1 Patients patient NNS cord-010092-uftc8inx 26 2 with with IN cord-010092-uftc8inx 26 3 refractory refractory JJ cord-010092-uftc8inx 26 4 B b NN cord-010092-uftc8inx 26 5 - - HYPH cord-010092-uftc8inx 26 6 cell cell NN cord-010092-uftc8inx 26 7 malignancies malignancy NNS cord-010092-uftc8inx 26 8 as as IN cord-010092-uftc8inx 26 9 non non JJ cord-010092-uftc8inx 26 10 - - JJ cord-010092-uftc8inx 26 11 Hodgkin Hodgkin NNP cord-010092-uftc8inx 26 12 lymphomas lymphoma NNS cord-010092-uftc8inx 26 13 ( ( -LRB- cord-010092-uftc8inx 26 14 NHL NHL NNP cord-010092-uftc8inx 26 15 ) ) -RRB- cord-010092-uftc8inx 26 16 resistant resistant JJ cord-010092-uftc8inx 26 17 to to IN cord-010092-uftc8inx 26 18 standard standard JJ cord-010092-uftc8inx 26 19 therapies therapy NNS cord-010092-uftc8inx 26 20 have have VBP cord-010092-uftc8inx 26 21 a a DT cord-010092-uftc8inx 26 22 dismal dismal JJ cord-010092-uftc8inx 26 23 prognosis prognosis NN cord-010092-uftc8inx 26 24 . . . cord-010092-uftc8inx 27 1 The the DT cord-010092-uftc8inx 27 2 outcome outcome NN cord-010092-uftc8inx 27 3 is be VBZ cord-010092-uftc8inx 27 4 even even RB cord-010092-uftc8inx 27 5 poorer poor JJR cord-010092-uftc8inx 27 6 in in IN cord-010092-uftc8inx 27 7 patients patient NNS cord-010092-uftc8inx 27 8 relapsing relapse VBG cord-010092-uftc8inx 27 9 after after IN cord-010092-uftc8inx 27 10 autologous autologous JJ cord-010092-uftc8inx 27 11 stem stem NN cord-010092-uftc8inx 27 12 cell cell NN cord-010092-uftc8inx 27 13 transplantation transplantation NN cord-010092-uftc8inx 27 14 . . . cord-010092-uftc8inx 28 1 Most Most JJS cord-010092-uftc8inx 28 2 of of IN cord-010092-uftc8inx 28 3 these these DT cord-010092-uftc8inx 28 4 patients patient NNS cord-010092-uftc8inx 28 5 do do VBP cord-010092-uftc8inx 28 6 not not RB cord-010092-uftc8inx 28 7 qualify qualify VB cord-010092-uftc8inx 28 8 for for IN cord-010092-uftc8inx 28 9 an an DT cord-010092-uftc8inx 28 10 allogeneic allogeneic JJ cord-010092-uftc8inx 28 11 hematopoietic hematopoietic JJ cord-010092-uftc8inx 28 12 cell cell NN cord-010092-uftc8inx 28 13 transplantation transplantation NN cord-010092-uftc8inx 28 14 ( ( -LRB- cord-010092-uftc8inx 28 15 HCT HCT NNP cord-010092-uftc8inx 28 16 ) ) -RRB- cord-010092-uftc8inx 28 17 due due IN cord-010092-uftc8inx 28 18 to to IN cord-010092-uftc8inx 28 19 refractory refractory JJ cord-010092-uftc8inx 28 20 disease disease NN cord-010092-uftc8inx 28 21 , , , cord-010092-uftc8inx 28 22 lack lack NN cord-010092-uftc8inx 28 23 of of IN cord-010092-uftc8inx 28 24 a a DT cord-010092-uftc8inx 28 25 suitable suitable JJ cord-010092-uftc8inx 28 26 allogeneic allogeneic NN cord-010092-uftc8inx 28 27 donor donor NN cord-010092-uftc8inx 28 28 , , , cord-010092-uftc8inx 28 29 higher high JJR cord-010092-uftc8inx 28 30 age age NN cord-010092-uftc8inx 28 31 or or CC cord-010092-uftc8inx 28 32 cumulative cumulative JJ cord-010092-uftc8inx 28 33 toxicity toxicity NN cord-010092-uftc8inx 28 34 of of IN cord-010092-uftc8inx 28 35 previous previous JJ cord-010092-uftc8inx 28 36 chemotherapy chemotherapy NN cord-010092-uftc8inx 28 37 . . . cord-010092-uftc8inx 29 1 Despite despite IN cord-010092-uftc8inx 29 2 patients patient NNS cord-010092-uftc8inx 29 3 undergoing undergo VBG cord-010092-uftc8inx 29 4 allogeneic allogeneic IN cord-010092-uftc8inx 29 5 HCT hct NN cord-010092-uftc8inx 29 6 normally normally RB cord-010092-uftc8inx 29 7 profit profit VBP cord-010092-uftc8inx 29 8 from from IN cord-010092-uftc8inx 29 9 a a DT cord-010092-uftc8inx 29 10 graft graft NN cord-010092-uftc8inx 29 11 - - HYPH cord-010092-uftc8inx 29 12 versus versus IN cord-010092-uftc8inx 29 13 -lymphoma -lymphoma HYPH cord-010092-uftc8inx 29 14 effect effect NN cord-010092-uftc8inx 29 15 , , , cord-010092-uftc8inx 29 16 overall overall JJ cord-010092-uftc8inx 29 17 survival survival NN cord-010092-uftc8inx 29 18 in in IN cord-010092-uftc8inx 29 19 patients patient NNS cord-010092-uftc8inx 29 20 with with IN cord-010092-uftc8inx 29 21 NHL NHL NNP cord-010092-uftc8inx 29 22 after after IN cord-010092-uftc8inx 29 23 HCT HCT NNP cord-010092-uftc8inx 29 24 remains remain VBZ cord-010092-uftc8inx 29 25 short short JJ cord-010092-uftc8inx 29 26 . . . cord-010092-uftc8inx 30 1 A a DT cord-010092-uftc8inx 30 2 similar similar JJ cord-010092-uftc8inx 30 3 situation situation NN cord-010092-uftc8inx 30 4 can can MD cord-010092-uftc8inx 30 5 be be VB cord-010092-uftc8inx 30 6 observed observe VBN cord-010092-uftc8inx 30 7 for for IN cord-010092-uftc8inx 30 8 patients patient NNS cord-010092-uftc8inx 30 9 with with IN cord-010092-uftc8inx 30 10 acute acute JJ cord-010092-uftc8inx 30 11 lymphoblastic lymphoblastic JJ cord-010092-uftc8inx 30 12 leukemia leukemia NN cord-010092-uftc8inx 30 13 ( ( -LRB- cord-010092-uftc8inx 30 14 ALL all DT cord-010092-uftc8inx 30 15 ) ) -RRB- cord-010092-uftc8inx 30 16 . . . cord-010092-uftc8inx 31 1 Therefore therefore RB cord-010092-uftc8inx 31 2 novel novel JJ cord-010092-uftc8inx 31 3 treatment treatment NN cord-010092-uftc8inx 31 4 modalities modality NNS cord-010092-uftc8inx 31 5 are be VBP cord-010092-uftc8inx 31 6 urgently urgently RB cord-010092-uftc8inx 31 7 needed need VBN cord-010092-uftc8inx 31 8 . . . cord-010092-uftc8inx 32 1 Chimeric chimeric JJ cord-010092-uftc8inx 32 2 antigen antigen NN cord-010092-uftc8inx 32 3 receptor receptor NN cord-010092-uftc8inx 32 4 ( ( -LRB- cord-010092-uftc8inx 32 5 CAR)-T CAR)-T NNP cord-010092-uftc8inx 32 6 cells cell NNS cord-010092-uftc8inx 32 7 , , , cord-010092-uftc8inx 32 8 a a DT cord-010092-uftc8inx 32 9 new new JJ cord-010092-uftc8inx 32 10 class class NN cord-010092-uftc8inx 32 11 of of IN cord-010092-uftc8inx 32 12 cellular cellular JJ cord-010092-uftc8inx 32 13 immunotherapy immunotherapy NN cord-010092-uftc8inx 32 14 involving involve VBG cord-010092-uftc8inx 32 15 ex ex NNP cord-010092-uftc8inx 32 16 vivo vivo JJ cord-010092-uftc8inx 32 17 genetic genetic JJ cord-010092-uftc8inx 32 18 modification modification NN cord-010092-uftc8inx 32 19 of of IN cord-010092-uftc8inx 32 20 T t NN cord-010092-uftc8inx 32 21 cells cell NNS cord-010092-uftc8inx 32 22 to to TO cord-010092-uftc8inx 32 23 incorporate incorporate VB cord-010092-uftc8inx 32 24 an an DT cord-010092-uftc8inx 32 25 engineered engineer VBN cord-010092-uftc8inx 32 26 CAR car NN cord-010092-uftc8inx 32 27 have have VBP cord-010092-uftc8inx 32 28 been be VBN cord-010092-uftc8inx 32 29 used use VBN cord-010092-uftc8inx 32 30 in in IN cord-010092-uftc8inx 32 31 clinical clinical JJ cord-010092-uftc8inx 32 32 trials trial NNS cord-010092-uftc8inx 32 33 . . . cord-010092-uftc8inx 33 1 In in IN cord-010092-uftc8inx 33 2 the the DT cord-010092-uftc8inx 33 3 majority majority NN cord-010092-uftc8inx 33 4 of of IN cord-010092-uftc8inx 33 5 studies study NNS cord-010092-uftc8inx 33 6 B b NN cord-010092-uftc8inx 33 7 - - HYPH cord-010092-uftc8inx 33 8 cell cell NN cord-010092-uftc8inx 33 9 malignancies malignancy NNS cord-010092-uftc8inx 33 10 treated treat VBN cord-010092-uftc8inx 33 11 with with IN cord-010092-uftc8inx 33 12 CD19 CD19 NNP cord-010092-uftc8inx 33 13 targeting target VBG cord-010092-uftc8inx 33 14 CAR CAR NNP cord-010092-uftc8inx 33 15 - - HYPH cord-010092-uftc8inx 33 16 T t NN cord-010092-uftc8inx 33 17 cells cell NNS cord-010092-uftc8inx 33 18 have have VBP cord-010092-uftc8inx 33 19 been be VBN cord-010092-uftc8inx 33 20 analyzed analyze VBN cord-010092-uftc8inx 33 21 . . . cord-010092-uftc8inx 34 1 Austria Austria NNP cord-010092-uftc8inx 34 2 had have VBD cord-010092-uftc8inx 34 3 the the DT cord-010092-uftc8inx 34 4 advantage advantage NN cord-010092-uftc8inx 34 5 to to TO cord-010092-uftc8inx 34 6 participate participate VB cord-010092-uftc8inx 34 7 in in IN cord-010092-uftc8inx 34 8 two two CD cord-010092-uftc8inx 34 9 international international JJ cord-010092-uftc8inx 34 10 trials trial NNS cord-010092-uftc8inx 34 11 in in IN cord-010092-uftc8inx 34 12 the the DT cord-010092-uftc8inx 34 13 past past NN cord-010092-uftc8inx 34 14 and and CC cord-010092-uftc8inx 34 15 is be VBZ cord-010092-uftc8inx 34 16 currently currently RB cord-010092-uftc8inx 34 17 involved involve VBN cord-010092-uftc8inx 34 18 in in IN cord-010092-uftc8inx 34 19 further further JJ cord-010092-uftc8inx 34 20 CAR car NN cord-010092-uftc8inx 34 21 - - HYPH cord-010092-uftc8inx 34 22 T T NNP cord-010092-uftc8inx 34 23 studies study NNS cord-010092-uftc8inx 34 24 . . . cord-010092-uftc8inx 35 1 Recently recently RB cord-010092-uftc8inx 35 2 , , , cord-010092-uftc8inx 35 3 results result NNS cord-010092-uftc8inx 35 4 from from IN cord-010092-uftc8inx 35 5 CD19 CD19 NNP cord-010092-uftc8inx 35 6 directed direct VBD cord-010092-uftc8inx 35 7 CAR CAR NNP cord-010092-uftc8inx 35 8 - - HYPH cord-010092-uftc8inx 35 9 T t NN cord-010092-uftc8inx 35 10 cell cell NN cord-010092-uftc8inx 35 11 trials trial NNS cord-010092-uftc8inx 35 12 with with IN cord-010092-uftc8inx 35 13 an an DT cord-010092-uftc8inx 35 14 increased increase VBN cord-010092-uftc8inx 35 15 follow follow NN cord-010092-uftc8inx 35 16 - - HYPH cord-010092-uftc8inx 35 17 up up NN cord-010092-uftc8inx 35 18 of of IN cord-010092-uftc8inx 35 19 patients patient NNS cord-010092-uftc8inx 35 20 led lead VBN cord-010092-uftc8inx 35 21 to to IN cord-010092-uftc8inx 35 22 FDA FDA NNP cord-010092-uftc8inx 35 23 ( ( -LRB- cord-010092-uftc8inx 35 24 Food Food NNP cord-010092-uftc8inx 35 25 and and CC cord-010092-uftc8inx 35 26 Drug Drug NNP cord-010092-uftc8inx 35 27 Administration Administration NNP cord-010092-uftc8inx 35 28 ) ) -RRB- cord-010092-uftc8inx 35 29 and and CC cord-010092-uftc8inx 35 30 EMA EMA NNP cord-010092-uftc8inx 35 31 ( ( -LRB- cord-010092-uftc8inx 35 32 European European NNP cord-010092-uftc8inx 35 33 Medicines Medicines NNPS cord-010092-uftc8inx 35 34 Agency Agency NNP cord-010092-uftc8inx 35 35 ) ) -RRB- cord-010092-uftc8inx 35 36 approval approval NN cord-010092-uftc8inx 35 37 of of IN cord-010092-uftc8inx 35 38 tisagenlecleucel tisagenlecleucel JJ cord-010092-uftc8inx 35 39 and and CC cord-010092-uftc8inx 35 40 axicabtagene axicabtagene NNP cord-010092-uftc8inx 35 41 ciloleucel ciloleucel NNP cord-010092-uftc8inx 35 42 . . . cord-010092-uftc8inx 36 1 Common common JJ cord-010092-uftc8inx 36 2 adverse adverse JJ cord-010092-uftc8inx 36 3 events event NNS cord-010092-uftc8inx 36 4 ( ( -LRB- cord-010092-uftc8inx 36 5 AEs AEs NNP cord-010092-uftc8inx 36 6 ) ) -RRB- cord-010092-uftc8inx 36 7 include include VBP cord-010092-uftc8inx 36 8 cytokine cytokine NN cord-010092-uftc8inx 36 9 release release NN cord-010092-uftc8inx 36 10 syndrome syndrome NN cord-010092-uftc8inx 36 11 and and CC cord-010092-uftc8inx 36 12 neurological neurological JJ cord-010092-uftc8inx 36 13 toxicity toxicity NN cord-010092-uftc8inx 36 14 , , , cord-010092-uftc8inx 36 15 which which WDT cord-010092-uftc8inx 36 16 may may MD cord-010092-uftc8inx 36 17 require require VB cord-010092-uftc8inx 36 18 admission admission NN cord-010092-uftc8inx 36 19 to to IN cord-010092-uftc8inx 36 20 an an DT cord-010092-uftc8inx 36 21 intensive intensive JJ cord-010092-uftc8inx 36 22 care care NN cord-010092-uftc8inx 36 23 unit unit NN cord-010092-uftc8inx 36 24 , , , cord-010092-uftc8inx 36 25 B B NNP cord-010092-uftc8inx 36 26 cell cell NN cord-010092-uftc8inx 36 27 aplasia aplasia NNP cord-010092-uftc8inx 36 28 and and CC cord-010092-uftc8inx 36 29 hemophagocytic hemophagocytic NNP cord-010092-uftc8inx 36 30 lymphohistiocytosis lymphohistiocytosis NNP cord-010092-uftc8inx 36 31 . . . cord-010092-uftc8inx 37 1 These these DT cord-010092-uftc8inx 37 2 AEs ae NNS cord-010092-uftc8inx 37 3 are be VBP cord-010092-uftc8inx 37 4 manageable manageable JJ cord-010092-uftc8inx 37 5 when when WRB cord-010092-uftc8inx 37 6 treated treat VBN cord-010092-uftc8inx 37 7 by by IN cord-010092-uftc8inx 37 8 an an DT cord-010092-uftc8inx 37 9 appropriately appropriately RB cord-010092-uftc8inx 37 10 trained train VBN cord-010092-uftc8inx 37 11 team team NN cord-010092-uftc8inx 37 12 following follow VBG cord-010092-uftc8inx 37 13 established establish VBN cord-010092-uftc8inx 37 14 algorithm algorithm NN cord-010092-uftc8inx 37 15 . . . cord-010092-uftc8inx 38 1 In in IN cord-010092-uftc8inx 38 2 this this DT cord-010092-uftc8inx 38 3 presentation presentation NN cord-010092-uftc8inx 38 4 , , , cord-010092-uftc8inx 38 5 results result NNS cord-010092-uftc8inx 38 6 of of IN cord-010092-uftc8inx 38 7 four four CD cord-010092-uftc8inx 38 8 large large JJ cord-010092-uftc8inx 38 9 phase phase NN cord-010092-uftc8inx 38 10 II ii CD cord-010092-uftc8inx 38 11 CD19CAR CD19CAR NNP cord-010092-uftc8inx 38 12 - - HYPH cord-010092-uftc8inx 38 13 T t NN cord-010092-uftc8inx 38 14 cell cell NN cord-010092-uftc8inx 38 15 trials trial NNS cord-010092-uftc8inx 38 16 for for IN cord-010092-uftc8inx 38 17 patients patient NNS cord-010092-uftc8inx 38 18 with with IN cord-010092-uftc8inx 38 19 NHL NHL NNP cord-010092-uftc8inx 38 20 and and CC cord-010092-uftc8inx 38 21 ALL all DT cord-010092-uftc8inx 38 22 and and CC cord-010092-uftc8inx 38 23 focus focus VBP cord-010092-uftc8inx 38 24 on on IN cord-010092-uftc8inx 38 25 AEs AEs NNP cord-010092-uftc8inx 38 26 is be VBZ cord-010092-uftc8inx 38 27 summarized summarize VBN cord-010092-uftc8inx 38 28 . . . cord-010092-uftc8inx 39 1 Preoperative preoperative JJ cord-010092-uftc8inx 39 2 anemia anemia NN cord-010092-uftc8inx 39 3 is be VBZ cord-010092-uftc8inx 39 4 a a DT cord-010092-uftc8inx 39 5 known know VBN cord-010092-uftc8inx 39 6 risk risk NN cord-010092-uftc8inx 39 7 factor factor NN cord-010092-uftc8inx 39 8 for for IN cord-010092-uftc8inx 39 9 increased increase VBN cord-010092-uftc8inx 39 10 perioperative perioperative JJ cord-010092-uftc8inx 39 11 morbidity morbidity NN cord-010092-uftc8inx 39 12 and and CC cord-010092-uftc8inx 39 13 mortality mortality NN cord-010092-uftc8inx 39 14 in in IN cord-010092-uftc8inx 39 15 patients patient NNS cord-010092-uftc8inx 39 16 undergoing undergo VBG cord-010092-uftc8inx 39 17 major major JJ cord-010092-uftc8inx 39 18 surgery surgery NN cord-010092-uftc8inx 39 19 . . . cord-010092-uftc8inx 40 1 Previous previous JJ cord-010092-uftc8inx 40 2 studies study NNS cord-010092-uftc8inx 40 3 have have VBP cord-010092-uftc8inx 40 4 not not RB cord-010092-uftc8inx 40 5 only only RB cord-010092-uftc8inx 40 6 shown show VBN cord-010092-uftc8inx 40 7 higher higher RBR cord-010092-uftc8inx 40 8 in in IN cord-010092-uftc8inx 40 9 - - HYPH cord-010092-uftc8inx 40 10 hospital hospital NN cord-010092-uftc8inx 40 11 mortality mortality NN cord-010092-uftc8inx 40 12 , , , cord-010092-uftc8inx 40 13 but but CC cord-010092-uftc8inx 40 14 also also RB cord-010092-uftc8inx 40 15 an an DT cord-010092-uftc8inx 40 16 increased increase VBN cord-010092-uftc8inx 40 17 hospital hospital NN cord-010092-uftc8inx 40 18 length length NN cord-010092-uftc8inx 40 19 of of IN cord-010092-uftc8inx 40 20 stay stay NN cord-010092-uftc8inx 40 21 , , , cord-010092-uftc8inx 40 22 greater great JJR cord-010092-uftc8inx 40 23 postoperative postoperative JJ cord-010092-uftc8inx 40 24 admission admission NN cord-010092-uftc8inx 40 25 rates rate NNS cord-010092-uftc8inx 40 26 to to TO cord-010092-uftc8inx 40 27 intensive intensive JJ cord-010092-uftc8inx 40 28 care care NN cord-010092-uftc8inx 40 29 and and CC cord-010092-uftc8inx 40 30 prolonged prolong VBN cord-010092-uftc8inx 40 31 use use NN cord-010092-uftc8inx 40 32 of of IN cord-010092-uftc8inx 40 33 mechanical mechanical JJ cord-010092-uftc8inx 40 34 ventilation ventilation NN cord-010092-uftc8inx 40 35 and and CC cord-010092-uftc8inx 40 36 intensive intensive JJ cord-010092-uftc8inx 40 37 care care NN cord-010092-uftc8inx 40 38 resources resource NNS cord-010092-uftc8inx 40 39 in in IN cord-010092-uftc8inx 40 40 patients patient NNS cord-010092-uftc8inx 40 41 with with IN cord-010092-uftc8inx 40 42 anemia anemia NN cord-010092-uftc8inx 40 43 compared compare VBN cord-010092-uftc8inx 40 44 to to IN cord-010092-uftc8inx 40 45 those those DT cord-010092-uftc8inx 40 46 with with IN cord-010092-uftc8inx 40 47 normal normal JJ cord-010092-uftc8inx 40 48 preoperative preoperative JJ cord-010092-uftc8inx 40 49 hemoglobin hemoglobin NN cord-010092-uftc8inx 40 50 concentrations concentration NNS cord-010092-uftc8inx 40 51 . . . cord-010092-uftc8inx 41 1 About about RB cord-010092-uftc8inx 41 2 30 30 CD cord-010092-uftc8inx 41 3 % % NN cord-010092-uftc8inx 41 4 of of IN cord-010092-uftc8inx 41 5 patients patient NNS cord-010092-uftc8inx 41 6 scheduled schedule VBN cord-010092-uftc8inx 41 7 for for IN cord-010092-uftc8inx 41 8 major major JJ cord-010092-uftc8inx 41 9 surgery surgery NN cord-010092-uftc8inx 41 10 suffer suffer VBP cord-010092-uftc8inx 41 11 from from IN cord-010092-uftc8inx 41 12 preoperative preoperative JJ cord-010092-uftc8inx 41 13 anemia anemia NN cord-010092-uftc8inx 41 14 . . . cord-010092-uftc8inx 42 1 This this DT cord-010092-uftc8inx 42 2 figure figure NN cord-010092-uftc8inx 42 3 is be VBZ cord-010092-uftc8inx 42 4 even even RB cord-010092-uftc8inx 42 5 higher high JJR cord-010092-uftc8inx 42 6 in in IN cord-010092-uftc8inx 42 7 patients patient NNS cord-010092-uftc8inx 42 8 requiring require VBG cord-010092-uftc8inx 42 9 orthotopic orthotopic JJ cord-010092-uftc8inx 42 10 liver liver NN cord-010092-uftc8inx 42 11 transplantation transplantation NN cord-010092-uftc8inx 42 12 , , , cord-010092-uftc8inx 42 13 where where WRB cord-010092-uftc8inx 42 14 up up IN cord-010092-uftc8inx 42 15 to to TO cord-010092-uftc8inx 42 16 75 75 CD cord-010092-uftc8inx 42 17 % % NN cord-010092-uftc8inx 42 18 of of IN cord-010092-uftc8inx 42 19 all all DT cord-010092-uftc8inx 42 20 patients patient NNS cord-010092-uftc8inx 42 21 are be VBP cord-010092-uftc8inx 42 22 diagnosed diagnose VBN cord-010092-uftc8inx 42 23 with with IN cord-010092-uftc8inx 42 24 anemia anemia NN cord-010092-uftc8inx 42 25 prior prior RB cord-010092-uftc8inx 42 26 to to IN cord-010092-uftc8inx 42 27 surgery surgery NN cord-010092-uftc8inx 42 28 . . . cord-010092-uftc8inx 43 1 Transfusion transfusion NN cord-010092-uftc8inx 43 2 of of IN cord-010092-uftc8inx 43 3 packed pack VBN cord-010092-uftc8inx 43 4 red red JJ cord-010092-uftc8inx 43 5 blood blood NN cord-010092-uftc8inx 43 6 cells cell NNS cord-010092-uftc8inx 43 7 ( ( -LRB- cord-010092-uftc8inx 43 8 PRBCs prbc NNS cord-010092-uftc8inx 43 9 ) ) -RRB- cord-010092-uftc8inx 43 10 is be VBZ cord-010092-uftc8inx 43 11 commonly commonly RB cord-010092-uftc8inx 43 12 used use VBN cord-010092-uftc8inx 43 13 to to TO cord-010092-uftc8inx 43 14 correct correct VB cord-010092-uftc8inx 43 15 anemic anemic JJ cord-010092-uftc8inx 43 16 hemoglobin hemoglobin NN cord-010092-uftc8inx 43 17 values value NNS cord-010092-uftc8inx 43 18 . . . cord-010092-uftc8inx 44 1 However however RB cord-010092-uftc8inx 44 2 , , , cord-010092-uftc8inx 44 3 transfusion transfusion NN cord-010092-uftc8inx 44 4 of of IN cord-010092-uftc8inx 44 5 PRBCs prbc NNS cord-010092-uftc8inx 44 6 has have VBZ cord-010092-uftc8inx 44 7 been be VBN cord-010092-uftc8inx 44 8 associated associate VBN cord-010092-uftc8inx 44 9 with with IN cord-010092-uftc8inx 44 10 increased increase VBN cord-010092-uftc8inx 44 11 morbidity morbidity NN cord-010092-uftc8inx 44 12 and and CC cord-010092-uftc8inx 44 13 mortality mortality NN cord-010092-uftc8inx 44 14 in in IN cord-010092-uftc8inx 44 15 patients patient NNS cord-010092-uftc8inx 44 16 undergoing undergo VBG cord-010092-uftc8inx 44 17 cardiac cardiac NN cord-010092-uftc8inx 44 18 , , , cord-010092-uftc8inx 44 19 orthopedic orthopedic NN cord-010092-uftc8inx 44 20 , , , cord-010092-uftc8inx 44 21 and and CC cord-010092-uftc8inx 44 22 abdominal abdominal JJ cord-010092-uftc8inx 44 23 surgery surgery NN cord-010092-uftc8inx 44 24 . . . cord-010092-uftc8inx 45 1 Additionally additionally RB cord-010092-uftc8inx 45 2 , , , cord-010092-uftc8inx 45 3 transfusion transfusion NN cord-010092-uftc8inx 45 4 of of IN cord-010092-uftc8inx 45 5 PRBCs prbc NNS cord-010092-uftc8inx 45 6 is be VBZ cord-010092-uftc8inx 45 7 associated associate VBN cord-010092-uftc8inx 45 8 with with IN cord-010092-uftc8inx 45 9 a a DT cord-010092-uftc8inx 45 10 greater great JJR cord-010092-uftc8inx 45 11 incidence incidence NN cord-010092-uftc8inx 45 12 of of IN cord-010092-uftc8inx 45 13 postoperative postoperative JJ cord-010092-uftc8inx 45 14 acute acute JJ cord-010092-uftc8inx 45 15 kidney kidney NN cord-010092-uftc8inx 45 16 injury injury NN cord-010092-uftc8inx 45 17 in in IN cord-010092-uftc8inx 45 18 patients patient NNS cord-010092-uftc8inx 45 19 undergoing undergo VBG cord-010092-uftc8inx 45 20 orthotopic orthotopic JJ cord-010092-uftc8inx 45 21 liver liver NN cord-010092-uftc8inx 45 22 transplantation transplantation NN cord-010092-uftc8inx 45 23 . . . cord-010092-uftc8inx 46 1 As as IN cord-010092-uftc8inx 46 2 preoperative preoperative JJ cord-010092-uftc8inx 46 3 anemia anemia NN cord-010092-uftc8inx 46 4 might may MD cord-010092-uftc8inx 46 5 increase increase VB cord-010092-uftc8inx 46 6 the the DT cord-010092-uftc8inx 46 7 perioperative perioperative JJ cord-010092-uftc8inx 46 8 use use NN cord-010092-uftc8inx 46 9 of of IN cord-010092-uftc8inx 46 10 PRBCs prbc NNS cord-010092-uftc8inx 46 11 , , , cord-010092-uftc8inx 46 12 negative negative JJ cord-010092-uftc8inx 46 13 effects effect NNS cord-010092-uftc8inx 46 14 observed observe VBN cord-010092-uftc8inx 46 15 after after IN cord-010092-uftc8inx 46 16 PRBC PRBC NNP cord-010092-uftc8inx 46 17 transfusions transfusion NNS cord-010092-uftc8inx 46 18 might may MD cord-010092-uftc8inx 46 19 even even RB cord-010092-uftc8inx 46 20 be be VB cord-010092-uftc8inx 46 21 augmented augment VBN cord-010092-uftc8inx 46 22 . . . cord-010092-uftc8inx 47 1 Data datum NNS cord-010092-uftc8inx 47 2 on on IN cord-010092-uftc8inx 47 3 the the DT cord-010092-uftc8inx 47 4 influence influence NN cord-010092-uftc8inx 47 5 of of IN cord-010092-uftc8inx 47 6 preoperative preoperative JJ cord-010092-uftc8inx 47 7 anemia anemia NN cord-010092-uftc8inx 47 8 on on IN cord-010092-uftc8inx 47 9 morbidity morbidity NN cord-010092-uftc8inx 47 10 and and CC cord-010092-uftc8inx 47 11 mortality mortality NN cord-010092-uftc8inx 47 12 after after IN cord-010092-uftc8inx 47 13 orthotopic orthotopic JJ cord-010092-uftc8inx 47 14 liver liver NN cord-010092-uftc8inx 47 15 transplantation transplantation NN cord-010092-uftc8inx 47 16 are be VBP cord-010092-uftc8inx 47 17 limited limited JJ cord-010092-uftc8inx 47 18 . . . cord-010092-uftc8inx 48 1 Thus thus RB cord-010092-uftc8inx 48 2 , , , cord-010092-uftc8inx 48 3 we -PRON- PRP cord-010092-uftc8inx 48 4 retrospectively retrospectively RB cord-010092-uftc8inx 48 5 analyzed analyze VBD cord-010092-uftc8inx 48 6 the the DT cord-010092-uftc8inx 48 7 association association NN cord-010092-uftc8inx 48 8 of of IN cord-010092-uftc8inx 48 9 preoperative preoperative JJ cord-010092-uftc8inx 48 10 anemia anemia NN cord-010092-uftc8inx 48 11 and and CC cord-010092-uftc8inx 48 12 mortality mortality NN cord-010092-uftc8inx 48 13 in in IN cord-010092-uftc8inx 48 14 adult adult NN cord-010092-uftc8inx 48 15 patients patient NNS cord-010092-uftc8inx 48 16 undergoing undergo VBG cord-010092-uftc8inx 48 17 orthotopic orthotopic JJ cord-010092-uftc8inx 48 18 liver liver NN cord-010092-uftc8inx 48 19 transplantation transplantation NN cord-010092-uftc8inx 48 20 at at IN cord-010092-uftc8inx 48 21 our -PRON- PRP$ cord-010092-uftc8inx 48 22 institution institution NN cord-010092-uftc8inx 48 23 . . . cord-010092-uftc8inx 49 1 In in IN cord-010092-uftc8inx 49 2 addition addition NN cord-010092-uftc8inx 49 3 , , , cord-010092-uftc8inx 49 4 we -PRON- PRP cord-010092-uftc8inx 49 5 examined examine VBD cord-010092-uftc8inx 49 6 the the DT cord-010092-uftc8inx 49 7 influence influence NN cord-010092-uftc8inx 49 8 of of IN cord-010092-uftc8inx 49 9 anemia anemia NN cord-010092-uftc8inx 49 10 on on IN cord-010092-uftc8inx 49 11 perioperative perioperative JJ cord-010092-uftc8inx 49 12 parameters parameter NNS cord-010092-uftc8inx 49 13 such such JJ cord-010092-uftc8inx 49 14 as as IN cord-010092-uftc8inx 49 15 transfusion transfusion NN cord-010092-uftc8inx 49 16 requirements requirement NNS cord-010092-uftc8inx 49 17 , , , cord-010092-uftc8inx 49 18 surgical surgical JJ cord-010092-uftc8inx 49 19 complications complication NNS cord-010092-uftc8inx 49 20 , , , cord-010092-uftc8inx 49 21 early early JJ cord-010092-uftc8inx 49 22 allograft allograft NN cord-010092-uftc8inx 49 23 dysfunction dysfunction NN cord-010092-uftc8inx 49 24 , , , cord-010092-uftc8inx 49 25 acute acute JJ cord-010092-uftc8inx 49 26 kidney kidney NN cord-010092-uftc8inx 49 27 injury injury NN cord-010092-uftc8inx 49 28 , , , cord-010092-uftc8inx 49 29 and and CC cord-010092-uftc8inx 49 30 the the DT cord-010092-uftc8inx 49 31 need need NN cord-010092-uftc8inx 49 32 for for IN cord-010092-uftc8inx 49 33 renal renal JJ cord-010092-uftc8inx 49 34 replacement replacement NN cord-010092-uftc8inx 49 35 therapy therapy NN cord-010092-uftc8inx 49 36 . . . cord-010092-uftc8inx 50 1 Based base VBN cord-010092-uftc8inx 50 2 on on IN cord-010092-uftc8inx 50 3 the the DT cord-010092-uftc8inx 50 4 results result NNS cord-010092-uftc8inx 50 5 obtained obtain VBN cord-010092-uftc8inx 50 6 in in IN cord-010092-uftc8inx 50 7 the the DT cord-010092-uftc8inx 50 8 retrospective retrospective JJ cord-010092-uftc8inx 50 9 analysis analysis NN cord-010092-uftc8inx 50 10 , , , cord-010092-uftc8inx 50 11 an an DT cord-010092-uftc8inx 50 12 ongoing ongoing JJ cord-010092-uftc8inx 50 13 prospective prospective JJ cord-010092-uftc8inx 50 14 randomized randomized JJ cord-010092-uftc8inx 50 15 clinical clinical JJ cord-010092-uftc8inx 50 16 trial trial NN cord-010092-uftc8inx 50 17 was be VBD cord-010092-uftc8inx 50 18 initiated initiate VBN cord-010092-uftc8inx 50 19 . . . cord-010092-uftc8inx 51 1 The the DT cord-010092-uftc8inx 51 2 two two CD cord-010092-uftc8inx 51 3 suspensive suspensive JJ cord-010092-uftc8inx 51 4 treatments treatment NNS cord-010092-uftc8inx 51 5 in in IN cord-010092-uftc8inx 51 6 sickle sickle NN cord-010092-uftc8inx 51 7 cell cell NN cord-010092-uftc8inx 51 8 disease disease NN cord-010092-uftc8inx 51 9 ( ( -LRB- cord-010092-uftc8inx 51 10 SCD SCD NNP cord-010092-uftc8inx 51 11 ) ) -RRB- cord-010092-uftc8inx 51 12 are be VBP cord-010092-uftc8inx 51 13 hydroxycarbamide hydroxycarbamide JJ cord-010092-uftc8inx 51 14 , , , cord-010092-uftc8inx 51 15 inducing induce VBG cord-010092-uftc8inx 51 16 the the DT cord-010092-uftc8inx 51 17 production production NN cord-010092-uftc8inx 51 18 of of IN cord-010092-uftc8inx 51 19 the the DT cord-010092-uftc8inx 51 20 functional functional JJ cord-010092-uftc8inx 51 21 HbF hbf NN cord-010092-uftc8inx 51 22 , , , cord-010092-uftc8inx 51 23 normally normally RB cord-010092-uftc8inx 51 24 repressed repress VBN cord-010092-uftc8inx 51 25 at at IN cord-010092-uftc8inx 51 26 birth birth NN cord-010092-uftc8inx 51 27 , , , cord-010092-uftc8inx 51 28 and and CC cord-010092-uftc8inx 51 29 Red red JJ cord-010092-uftc8inx 51 30 blood blood NN cord-010092-uftc8inx 51 31 cell cell NN cord-010092-uftc8inx 51 32 ( ( -LRB- cord-010092-uftc8inx 51 33 RBC RBC NNP cord-010092-uftc8inx 51 34 ) ) -RRB- cord-010092-uftc8inx 51 35 transfusion transfusion NN cord-010092-uftc8inx 51 36 , , , cord-010092-uftc8inx 51 37 a a DT cord-010092-uftc8inx 51 38 critical critical JJ cord-010092-uftc8inx 51 39 component component NN cord-010092-uftc8inx 51 40 of of IN cord-010092-uftc8inx 51 41 SCD SCD NNP cord-010092-uftc8inx 51 42 management management NN cord-010092-uftc8inx 51 43 . . . cord-010092-uftc8inx 52 1 However however RB cord-010092-uftc8inx 52 2 , , , cord-010092-uftc8inx 52 3 RBC RBC NNP cord-010092-uftc8inx 52 4 transfusion transfusion NN cord-010092-uftc8inx 52 5 is be VBZ cord-010092-uftc8inx 52 6 not not RB cord-010092-uftc8inx 52 7 without without IN cord-010092-uftc8inx 52 8 risk risk NN cord-010092-uftc8inx 52 9 . . . cord-010092-uftc8inx 53 1 Repeat repeat VB cord-010092-uftc8inx 53 2 exposure exposure NN cord-010092-uftc8inx 53 3 to to IN cord-010092-uftc8inx 53 4 allogeneic allogeneic NN cord-010092-uftc8inx 53 5 RBCs rbc NNS cord-010092-uftc8inx 53 6 can can MD cord-010092-uftc8inx 53 7 result result VB cord-010092-uftc8inx 53 8 in in IN cord-010092-uftc8inx 53 9 the the DT cord-010092-uftc8inx 53 10 development development NN cord-010092-uftc8inx 53 11 of of IN cord-010092-uftc8inx 53 12 RBC RBC NNP cord-010092-uftc8inx 53 13 alloantibodies alloantibody NNS cord-010092-uftc8inx 53 14 which which WDT cord-010092-uftc8inx 53 15 can can MD cord-010092-uftc8inx 53 16 make make VB cord-010092-uftc8inx 53 17 it -PRON- PRP cord-010092-uftc8inx 53 18 difficult difficult JJ cord-010092-uftc8inx 53 19 to to TO cord-010092-uftc8inx 53 20 find find VB cord-010092-uftc8inx 53 21 compatible compatible JJ cord-010092-uftc8inx 53 22 RBCs rbc NNS cord-010092-uftc8inx 53 23 for for IN cord-010092-uftc8inx 53 24 future future JJ cord-010092-uftc8inx 53 25 transfusions transfusion NNS cord-010092-uftc8inx 53 26 . . . cord-010092-uftc8inx 54 1 However however RB cord-010092-uftc8inx 54 2 , , , cord-010092-uftc8inx 54 3 the the DT cord-010092-uftc8inx 54 4 main main JJ cord-010092-uftc8inx 54 5 concern concern NN cord-010092-uftc8inx 54 6 of of IN cord-010092-uftc8inx 54 7 alloimmunization alloimmunization NN cord-010092-uftc8inx 54 8 is be VBZ cord-010092-uftc8inx 54 9 the the DT cord-010092-uftc8inx 54 10 development development NN cord-010092-uftc8inx 54 11 of of IN cord-010092-uftc8inx 54 12 hemolytic hemolytic JJ cord-010092-uftc8inx 54 13 transfusion transfusion NN cord-010092-uftc8inx 54 14 reaction reaction NN cord-010092-uftc8inx 54 15 , , , cord-010092-uftc8inx 54 16 with with IN cord-010092-uftc8inx 54 17 in in IN cord-010092-uftc8inx 54 18 the the DT cord-010092-uftc8inx 54 19 most most RBS cord-010092-uftc8inx 54 20 severe severe JJ cord-010092-uftc8inx 54 21 cases case NNS cord-010092-uftc8inx 54 22 , , , cord-010092-uftc8inx 54 23 hyperhemolysis hyperhemolysis NN cord-010092-uftc8inx 54 24 , , , cord-010092-uftc8inx 54 25 leading lead VBG cord-010092-uftc8inx 54 26 to to IN cord-010092-uftc8inx 54 27 multi multi JJ cord-010092-uftc8inx 54 28 organ organ NN cord-010092-uftc8inx 54 29 failure failure NN cord-010092-uftc8inx 54 30 and and CC cord-010092-uftc8inx 54 31 death death NN cord-010092-uftc8inx 54 32 in in IN cord-010092-uftc8inx 54 33 4 4 CD cord-010092-uftc8inx 54 34 % % NN cord-010092-uftc8inx 54 35 of of IN cord-010092-uftc8inx 54 36 the the DT cord-010092-uftc8inx 54 37 cases case NNS cord-010092-uftc8inx 54 38 . . . cord-010092-uftc8inx 55 1 The the DT cord-010092-uftc8inx 55 2 prevention prevention NN cord-010092-uftc8inx 55 3 of of IN cord-010092-uftc8inx 55 4 this this DT cord-010092-uftc8inx 55 5 life life NN cord-010092-uftc8inx 55 6 threatening threaten VBG cord-010092-uftc8inx 55 7 condition condition NN cord-010092-uftc8inx 55 8 must must MD cord-010092-uftc8inx 55 9 be be VB cord-010092-uftc8inx 55 10 based base VBN cord-010092-uftc8inx 55 11 on on IN cord-010092-uftc8inx 55 12 risk risk NN cord-010092-uftc8inx 55 13 factors factor NNS cord-010092-uftc8inx 55 14 . . . cord-010092-uftc8inx 56 1 However however RB cord-010092-uftc8inx 56 2 , , , cord-010092-uftc8inx 56 3 although although IN cord-010092-uftc8inx 56 4 some some DT cord-010092-uftc8inx 56 5 risk risk NN cord-010092-uftc8inx 56 6 factors factor NNS cord-010092-uftc8inx 56 7 , , , cord-010092-uftc8inx 56 8 such such JJ cord-010092-uftc8inx 56 9 as as IN cord-010092-uftc8inx 56 10 alloimmunization alloimmunization NN cord-010092-uftc8inx 56 11 , , , cord-010092-uftc8inx 56 12 have have VBP cord-010092-uftc8inx 56 13 been be VBN cord-010092-uftc8inx 56 14 identified identify VBN cord-010092-uftc8inx 56 15 , , , cord-010092-uftc8inx 56 16 much much JJ cord-010092-uftc8inx 56 17 of of IN cord-010092-uftc8inx 56 18 the the DT cord-010092-uftc8inx 56 19 mechanism mechanism NN cord-010092-uftc8inx 56 20 underlying underlie VBG cord-010092-uftc8inx 56 21 DHTR DHTR NNP cord-010092-uftc8inx 56 22 remains remain VBZ cord-010092-uftc8inx 56 23 a a DT cord-010092-uftc8inx 56 24 mystery mystery NN cord-010092-uftc8inx 56 25 , , , cord-010092-uftc8inx 56 26 particularly particularly RB cord-010092-uftc8inx 56 27 in in IN cord-010092-uftc8inx 56 28 severe severe JJ cord-010092-uftc8inx 56 29 cases case NNS cord-010092-uftc8inx 56 30 presenting present VBG cord-010092-uftc8inx 56 31 hyperhemolysis hyperhemolysis NN cord-010092-uftc8inx 56 32 . . . cord-010092-uftc8inx 57 1 Here here RB cord-010092-uftc8inx 57 2 we -PRON- PRP cord-010092-uftc8inx 57 3 will will MD cord-010092-uftc8inx 57 4 describe describe VB cord-010092-uftc8inx 57 5 the the DT cord-010092-uftc8inx 57 6 current current JJ cord-010092-uftc8inx 57 7 and and CC cord-010092-uftc8inx 57 8 future future JJ cord-010092-uftc8inx 57 9 development development NN cord-010092-uftc8inx 57 10 to to TO cord-010092-uftc8inx 57 11 prevent prevent VB cord-010092-uftc8inx 57 12 and and CC cord-010092-uftc8inx 57 13 treat treat VB cord-010092-uftc8inx 57 14 this this DT cord-010092-uftc8inx 57 15 severe severe JJ cord-010092-uftc8inx 57 16 syndrome syndrome NN cord-010092-uftc8inx 58 1 In in IN cord-010092-uftc8inx 58 2 order order NN cord-010092-uftc8inx 58 3 to to TO cord-010092-uftc8inx 58 4 decrease decrease VB cord-010092-uftc8inx 58 5 exposure exposure NN cord-010092-uftc8inx 58 6 to to IN cord-010092-uftc8inx 58 7 transfusion transfusion NN cord-010092-uftc8inx 58 8 in in IN cord-010092-uftc8inx 58 9 SCD SCD NNP cord-010092-uftc8inx 58 10 but but CC cord-010092-uftc8inx 58 11 also also RB cord-010092-uftc8inx 58 12 improve improve VB cord-010092-uftc8inx 58 13 red red JJ cord-010092-uftc8inx 58 14 blood blood NN cord-010092-uftc8inx 58 15 cell cell NN cord-010092-uftc8inx 58 16 quality quality NN cord-010092-uftc8inx 58 17 , , , cord-010092-uftc8inx 58 18 some some DT cord-010092-uftc8inx 58 19 new new JJ cord-010092-uftc8inx 58 20 products product NNS cord-010092-uftc8inx 58 21 are be VBP cord-010092-uftc8inx 58 22 developed develop VBN cord-010092-uftc8inx 58 23 . . . cord-010092-uftc8inx 59 1 Oxidative oxidative JJ cord-010092-uftc8inx 59 2 damage damage NN cord-010092-uftc8inx 59 3 is be VBZ cord-010092-uftc8inx 59 4 one one CD cord-010092-uftc8inx 59 5 of of IN cord-010092-uftc8inx 59 6 the the DT cord-010092-uftc8inx 59 7 parameter parameter NN cord-010092-uftc8inx 59 8 that that WDT cord-010092-uftc8inx 59 9 could could MD cord-010092-uftc8inx 59 10 be be VB cord-010092-uftc8inx 59 11 diminished diminish VBN cord-010092-uftc8inx 59 12 . . . cord-010092-uftc8inx 60 1 Some some DT cord-010092-uftc8inx 60 2 work work NN cord-010092-uftc8inx 60 3 is be VBZ cord-010092-uftc8inx 60 4 also also RB cord-010092-uftc8inx 60 5 ongoing ongoing JJ cord-010092-uftc8inx 60 6 to to TO cord-010092-uftc8inx 60 7 prevent prevent VB cord-010092-uftc8inx 60 8 filter filter NN cord-010092-uftc8inx 60 9 blockage blockage NN cord-010092-uftc8inx 60 10 during during IN cord-010092-uftc8inx 60 11 leucodepletion leucodepletion NN cord-010092-uftc8inx 60 12 of of IN cord-010092-uftc8inx 60 13 precious precious JJ cord-010092-uftc8inx 60 14 RBCs rbc NNS cord-010092-uftc8inx 60 15 units unit NNS cord-010092-uftc8inx 60 16 from from IN cord-010092-uftc8inx 60 17 Afro afro JJ cord-010092-uftc8inx 60 18 - - HYPH cord-010092-uftc8inx 60 19 Caribbean caribbean JJ cord-010092-uftc8inx 60 20 donors donor NNS cord-010092-uftc8inx 60 21 carrying carry VBG cord-010092-uftc8inx 60 22 the the DT cord-010092-uftc8inx 60 23 sickle sickle NN cord-010092-uftc8inx 60 24 cell cell NN cord-010092-uftc8inx 60 25 trait trait NN cord-010092-uftc8inx 60 26 . . . cord-010092-uftc8inx 61 1 Finally finally RB cord-010092-uftc8inx 61 2 , , , cord-010092-uftc8inx 61 3 in in IN cord-010092-uftc8inx 61 4 countries country NNS cord-010092-uftc8inx 61 5 with with IN cord-010092-uftc8inx 61 6 higher high JJR cord-010092-uftc8inx 61 7 risks risk NNS cord-010092-uftc8inx 61 8 of of IN cord-010092-uftc8inx 61 9 transmission transmission NN cord-010092-uftc8inx 61 10 of of IN cord-010092-uftc8inx 61 11 infectious infectious JJ cord-010092-uftc8inx 61 12 disease disease NN cord-010092-uftc8inx 61 13 , , , cord-010092-uftc8inx 61 14 treatment treatment NN cord-010092-uftc8inx 61 15 of of IN cord-010092-uftc8inx 61 16 red red JJ cord-010092-uftc8inx 61 17 blood blood NN cord-010092-uftc8inx 61 18 cell cell NN cord-010092-uftc8inx 61 19 units unit NNS cord-010092-uftc8inx 61 20 against against IN cord-010092-uftc8inx 61 21 infectious infectious JJ cord-010092-uftc8inx 61 22 agents agent NNS cord-010092-uftc8inx 61 23 can can MD cord-010092-uftc8inx 61 24 be be VB cord-010092-uftc8inx 61 25 discussed discuss VBN cord-010092-uftc8inx 61 26 . . . cord-010092-uftc8inx 62 1 The the DT cord-010092-uftc8inx 62 2 only only JJ cord-010092-uftc8inx 62 3 current current JJ cord-010092-uftc8inx 62 4 curative curative JJ cord-010092-uftc8inx 62 5 treatment treatment NN cord-010092-uftc8inx 62 6 of of IN cord-010092-uftc8inx 62 7 SCD SCD NNP cord-010092-uftc8inx 62 8 is be VBZ cord-010092-uftc8inx 62 9 hematopoietic hematopoietic JJ cord-010092-uftc8inx 62 10 stem stem NN cord-010092-uftc8inx 62 11 cell cell NN cord-010092-uftc8inx 62 12 transplantation transplantation NN cord-010092-uftc8inx 62 13 ( ( -LRB- cord-010092-uftc8inx 62 14 HCS HCS NNP cord-010092-uftc8inx 62 15 ) ) -RRB- cord-010092-uftc8inx 62 16 . . . cord-010092-uftc8inx 63 1 However however RB cord-010092-uftc8inx 63 2 , , , cord-010092-uftc8inx 63 3 the the DT cord-010092-uftc8inx 63 4 occurrence occurrence NN cord-010092-uftc8inx 63 5 , , , cord-010092-uftc8inx 63 6 frequency frequency NN cord-010092-uftc8inx 63 7 , , , cord-010092-uftc8inx 63 8 and and CC cord-010092-uftc8inx 63 9 effects effect NNS cord-010092-uftc8inx 63 10 of of IN cord-010092-uftc8inx 63 11 immune immune JJ cord-010092-uftc8inx 63 12 hematologic hematologic JJ cord-010092-uftc8inx 63 13 complications complication NNS cord-010092-uftc8inx 63 14 in in IN cord-010092-uftc8inx 63 15 HCS HCS NNP cord-010092-uftc8inx 63 16 remain remain VBP cord-010092-uftc8inx 63 17 and and CC cord-010092-uftc8inx 63 18 will will MD cord-010092-uftc8inx 63 19 be be VB cord-010092-uftc8inx 63 20 discussed discuss VBN cord-010092-uftc8inx 63 21 . . . cord-010092-uftc8inx 64 1 Finally finally RB cord-010092-uftc8inx 64 2 , , , cord-010092-uftc8inx 64 3 gene gene NN cord-010092-uftc8inx 64 4 therapy therapy NN cord-010092-uftc8inx 64 5 is be VBZ cord-010092-uftc8inx 64 6 a a DT cord-010092-uftc8inx 64 7 real real JJ cord-010092-uftc8inx 64 8 hope hope NN cord-010092-uftc8inx 64 9 as as IN cord-010092-uftc8inx 64 10 a a DT cord-010092-uftc8inx 64 11 definitive definitive JJ cord-010092-uftc8inx 64 12 curative curative JJ cord-010092-uftc8inx 64 13 treatment treatment NN cord-010092-uftc8inx 64 14 . . . cord-010092-uftc8inx 65 1 Clinical clinical JJ cord-010092-uftc8inx 65 2 trials trial NNS cord-010092-uftc8inx 65 3 are be VBP cord-010092-uftc8inx 65 4 ongoing ongoing JJ cord-010092-uftc8inx 65 5 in in IN cord-010092-uftc8inx 65 6 France France NNP cord-010092-uftc8inx 65 7 and and CC cord-010092-uftc8inx 65 8 will will MD cord-010092-uftc8inx 65 9 be be VB cord-010092-uftc8inx 65 10 discussed discuss VBN cord-010092-uftc8inx 65 11 as as RB cord-010092-uftc8inx 65 12 well well RB cord-010092-uftc8inx 65 13 as as IN cord-010092-uftc8inx 65 14 the the DT cord-010092-uftc8inx 65 15 remaining remain VBG cord-010092-uftc8inx 65 16 place place NN cord-010092-uftc8inx 65 17 of of IN cord-010092-uftc8inx 65 18 transfusion transfusion NN cord-010092-uftc8inx 65 19 in in IN cord-010092-uftc8inx 65 20 this this DT cord-010092-uftc8inx 65 21 therapeutic therapeutic JJ cord-010092-uftc8inx 65 22 . . . cord-010092-uftc8inx 66 1 In in IN cord-010092-uftc8inx 66 2 the the DT cord-010092-uftc8inx 66 3 context context NN cord-010092-uftc8inx 66 4 of of IN cord-010092-uftc8inx 66 5 the the DT cord-010092-uftc8inx 66 6 Chronic Chronic NNP cord-010092-uftc8inx 66 7 Myeloid Myeloid NNP cord-010092-uftc8inx 66 8 Leukemia Leukemia NNP cord-010092-uftc8inx 66 9 ( ( -LRB- cord-010092-uftc8inx 66 10 CML CML NNP cord-010092-uftc8inx 66 11 ) ) -RRB- cord-010092-uftc8inx 66 12 , , , cord-010092-uftc8inx 66 13 we -PRON- PRP cord-010092-uftc8inx 66 14 have have VBP cord-010092-uftc8inx 66 15 hypothesized hypothesize VBN cord-010092-uftc8inx 66 16 that that IN cord-010092-uftc8inx 66 17 quiescent quiescent JJ cord-010092-uftc8inx 66 18 Leukemic Leukemic NNP cord-010092-uftc8inx 66 19 Hematopoietic Hematopoietic NNP cord-010092-uftc8inx 66 20 Stem Stem NNP cord-010092-uftc8inx 66 21 Cells Cells NNPS cord-010092-uftc8inx 66 22 ( ( -LRB- cord-010092-uftc8inx 66 23 HSC HSC NNP cord-010092-uftc8inx 66 24 ) ) -RRB- cord-010092-uftc8inx 66 25 compartment compartment NN cord-010092-uftc8inx 66 26 , , , cord-010092-uftc8inx 66 27 escaping escape VBG cord-010092-uftc8inx 66 28 to to IN cord-010092-uftc8inx 66 29 the the DT cord-010092-uftc8inx 66 30 current current JJ cord-010092-uftc8inx 66 31 tyrosine tyrosine NN cord-010092-uftc8inx 66 32 kinase kinase NN cord-010092-uftc8inx 66 33 inhibitors inhibitor NNS cord-010092-uftc8inx 66 34 ( ( -LRB- cord-010092-uftc8inx 66 35 TKis TKis NNP cord-010092-uftc8inx 66 36 ) ) -RRB- cord-010092-uftc8inx 66 37 treatment treatment NN cord-010092-uftc8inx 66 38 , , , cord-010092-uftc8inx 66 39 in in IN cord-010092-uftc8inx 66 40 part part NN cord-010092-uftc8inx 66 41 associated associate VBN cord-010092-uftc8inx 66 42 in in IN cord-010092-uftc8inx 66 43 the the DT cord-010092-uftc8inx 66 44 molecular molecular JJ cord-010092-uftc8inx 66 45 relapse relapse NN cord-010092-uftc8inx 66 46 , , , cord-010092-uftc8inx 66 47 may may MD cord-010092-uftc8inx 66 48 be be VB cord-010092-uftc8inx 66 49 targeted target VBN cord-010092-uftc8inx 66 50 by by IN cord-010092-uftc8inx 66 51 CART cart NN cord-010092-uftc8inx 66 52 - - HYPH cord-010092-uftc8inx 66 53 cells cell NNS cord-010092-uftc8inx 66 54 immunotherapy immunotherapy NN cord-010092-uftc8inx 66 55 . . . cord-010092-uftc8inx 67 1 Gene gene NN cord-010092-uftc8inx 67 2 expression expression NN cord-010092-uftc8inx 67 3 profiling profiling NN cord-010092-uftc8inx 67 4 studies study NNS cord-010092-uftc8inx 67 5 have have VBP cord-010092-uftc8inx 67 6 established establish VBN cord-010092-uftc8inx 67 7 that that IN cord-010092-uftc8inx 67 8 a a DT cord-010092-uftc8inx 67 9 cell cell NN cord-010092-uftc8inx 67 10 surface surface NN cord-010092-uftc8inx 67 11 biomarker biomarker NN cord-010092-uftc8inx 67 12 IL-1RAP IL-1RAP NNP cord-010092-uftc8inx 67 13 is be VBZ cord-010092-uftc8inx 67 14 expressed express VBN cord-010092-uftc8inx 67 15 by by IN cord-010092-uftc8inx 67 16 the the DT cord-010092-uftc8inx 67 17 leukemic leukemic NN cord-010092-uftc8inx 67 18 but but CC cord-010092-uftc8inx 67 19 not not RB cord-010092-uftc8inx 67 20 by by IN cord-010092-uftc8inx 67 21 the the DT cord-010092-uftc8inx 67 22 normal normal JJ cord-010092-uftc8inx 67 23 CD34 CD34 NNP cord-010092-uftc8inx 68 1 + + CC cord-010092-uftc8inx 69 1 /CD38-HSC /CD38-HSC NFP cord-010092-uftc8inx 69 2 . . . cord-010092-uftc8inx 70 1 This this DT cord-010092-uftc8inx 70 2 talk talk NN cord-010092-uftc8inx 70 3 will will MD cord-010092-uftc8inx 70 4 focus focus VB cord-010092-uftc8inx 70 5 of of IN cord-010092-uftc8inx 70 6 the the DT cord-010092-uftc8inx 70 7 whole whole JJ cord-010092-uftc8inx 70 8 process process NN cord-010092-uftc8inx 70 9 of of IN cord-010092-uftc8inx 70 10 development development NN cord-010092-uftc8inx 70 11 of of IN cord-010092-uftc8inx 70 12 a a DT cord-010092-uftc8inx 70 13 CART cart NN cord-010092-uftc8inx 70 14 - - HYPH cord-010092-uftc8inx 70 15 cells cell NNS cord-010092-uftc8inx 70 16 starting start VBG cord-010092-uftc8inx 70 17 from from IN cord-010092-uftc8inx 70 18 recombinant recombinant JJ cord-010092-uftc8inx 70 19 IL-1RAP IL-1RAP NNP cord-010092-uftc8inx 70 20 protein protein NN cord-010092-uftc8inx 70 21 mice mice NN cord-010092-uftc8inx 70 22 immunization immunization NN cord-010092-uftc8inx 70 23 to to TO cord-010092-uftc8inx 70 24 produce produce VB cord-010092-uftc8inx 70 25 a a DT cord-010092-uftc8inx 70 26 specific specific JJ cord-010092-uftc8inx 70 27 monoclonal monoclonal JJ cord-010092-uftc8inx 70 28 antibody antibody NN cord-010092-uftc8inx 70 29 ( ( -LRB- cord-010092-uftc8inx 70 30 mAb mAb NNS cord-010092-uftc8inx 70 31 ) ) -RRB- cord-010092-uftc8inx 70 32 , , , cord-010092-uftc8inx 70 33 to to IN cord-010092-uftc8inx 70 34 the the DT cord-010092-uftc8inx 70 35 proof proof NN cord-010092-uftc8inx 70 36 of of IN cord-010092-uftc8inx 70 37 concept concept NN cord-010092-uftc8inx 70 38 demonstration demonstration NN cord-010092-uftc8inx 70 39 , , , cord-010092-uftc8inx 70 40 before before IN cord-010092-uftc8inx 70 41 moving move VBG cord-010092-uftc8inx 70 42 into into IN cord-010092-uftc8inx 70 43 the the DT cord-010092-uftc8inx 70 44 clinic clinic NN cord-010092-uftc8inx 70 45 . . . cord-010092-uftc8inx 71 1 We -PRON- PRP cord-010092-uftc8inx 71 2 produced produce VBD cord-010092-uftc8inx 71 3 and and CC cord-010092-uftc8inx 71 4 selected select VBD cord-010092-uftc8inx 71 5 a a DT cord-010092-uftc8inx 71 6 specific specific JJ cord-010092-uftc8inx 71 7 anti anti JJ cord-010092-uftc8inx 71 8 - - JJ cord-010092-uftc8inx 71 9 IL-1RAP il-1rap JJ cord-010092-uftc8inx 71 10 mAb mab NN cord-010092-uftc8inx 71 11 ( ( -LRB- cord-010092-uftc8inx 71 12 # # NN cord-010092-uftc8inx 71 13 A3C3 A3C3 NNP cord-010092-uftc8inx 71 14 clone clone NN cord-010092-uftc8inx 71 15 , , , cord-010092-uftc8inx 71 16 Diaclone Diaclone NNP cord-010092-uftc8inx 71 17 SA SA NNP cord-010092-uftc8inx 71 18 , , , cord-010092-uftc8inx 71 19 Besanc Besanc NNP cord-010092-uftc8inx 71 20 ßon ßon NN cord-010092-uftc8inx 71 21 , , , cord-010092-uftc8inx 71 22 France France NNP cord-010092-uftc8inx 71 23 ) ) -RRB- cord-010092-uftc8inx 71 24 . . . cord-010092-uftc8inx 72 1 After after IN cord-010092-uftc8inx 72 2 molecular molecular JJ cord-010092-uftc8inx 72 3 characterization characterization NN cord-010092-uftc8inx 72 4 of of IN cord-010092-uftc8inx 72 5 antigen antigen NN cord-010092-uftc8inx 72 6 - - HYPH cord-010092-uftc8inx 72 7 binding bind VBG cord-010092-uftc8inx 72 8 domain domain NN cord-010092-uftc8inx 72 9 , , , cord-010092-uftc8inx 72 10 nucleotide nucleotide JJ cord-010092-uftc8inx 72 11 sequences sequence NNS cord-010092-uftc8inx 72 12 were be VBD cord-010092-uftc8inx 72 13 fused fuse VBN cord-010092-uftc8inx 72 14 with with IN cord-010092-uftc8inx 72 15 3rd 3rd JJ cord-010092-uftc8inx 72 16 generation generation NN cord-010092-uftc8inx 72 17 T T NNP cord-010092-uftc8inx 72 18 cell cell NN cord-010092-uftc8inx 72 19 activation activation NN cord-010092-uftc8inx 72 20 coding coding NN cord-010092-uftc8inx 72 21 sequences sequence NNS cord-010092-uftc8inx 72 22 and and CC cord-010092-uftc8inx 72 23 cloned clone VBN cord-010092-uftc8inx 72 24 as as IN cord-010092-uftc8inx 72 25 a a DT cord-010092-uftc8inx 72 26 single single JJ cord-010092-uftc8inx 72 27 chain chain NN cord-010092-uftc8inx 72 28 into into IN cord-010092-uftc8inx 72 29 a a DT cord-010092-uftc8inx 72 30 lentiviral lentiviral JJ cord-010092-uftc8inx 72 31 backbone backbone NN cord-010092-uftc8inx 72 32 comprising comprise VBG cord-010092-uftc8inx 72 33 a a DT cord-010092-uftc8inx 72 34 safety safety NN cord-010092-uftc8inx 72 35 switch switch NN cord-010092-uftc8inx 72 36 suicide suicide NN cord-010092-uftc8inx 72 37 gene gene NN cord-010092-uftc8inx 72 38 iCASP9 iCASP9 NNP cord-010092-uftc8inx 72 39 ( ( -LRB- cord-010092-uftc8inx 72 40 inducible inducible JJ cord-010092-uftc8inx 72 41 Caspase Caspase NNP cord-010092-uftc8inx 72 42 9 9 CD cord-010092-uftc8inx 72 43 ) ) -RRB- cord-010092-uftc8inx 72 44 and and CC cord-010092-uftc8inx 72 45 a a DT cord-010092-uftc8inx 72 46 monitoring monitoring NN cord-010092-uftc8inx 72 47 / / SYM cord-010092-uftc8inx 72 48 selection selection NN cord-010092-uftc8inx 72 49 cell cell NN cord-010092-uftc8inx 72 50 surface surface NN cord-010092-uftc8inx 72 51 marker marker NN cord-010092-uftc8inx 72 52 ΔCD19 ΔCD19 NNP cord-010092-uftc8inx 72 53 . . . cord-010092-uftc8inx 73 1 We -PRON- PRP cord-010092-uftc8inx 73 2 demonstrated demonstrate VBD cord-010092-uftc8inx 73 3 in in IN cord-010092-uftc8inx 73 4 - - HYPH cord-010092-uftc8inx 73 5 vitro vitro FW cord-010092-uftc8inx 73 6 and and CC cord-010092-uftc8inx 73 7 in in IN cord-010092-uftc8inx 73 8 an an DT cord-010092-uftc8inx 73 9 in in IN cord-010092-uftc8inx 73 10 - - HYPH cord-010092-uftc8inx 73 11 vivo vivo NN cord-010092-uftc8inx 73 12 xenograft xenograft NN cord-010092-uftc8inx 73 13 murine murine NN cord-010092-uftc8inx 73 14 model model NN cord-010092-uftc8inx 73 15 that that WDT cord-010092-uftc8inx 73 16 IL-1RAP IL-1RAP NNP cord-010092-uftc8inx 73 17 CAR CAR NNP cord-010092-uftc8inx 73 18 T t NN cord-010092-uftc8inx 73 19 cells cell NNS cord-010092-uftc8inx 73 20 can can MD cord-010092-uftc8inx 73 21 be be VB cord-010092-uftc8inx 73 22 activated activate VBN cord-010092-uftc8inx 73 23 in in IN cord-010092-uftc8inx 73 24 the the DT cord-010092-uftc8inx 73 25 presence presence NN cord-010092-uftc8inx 73 26 of of IN cord-010092-uftc8inx 73 27 IL-1RAP+ IL-1RAP+ NNP cord-010092-uftc8inx 73 28 cell cell NN cord-010092-uftc8inx 73 29 lines line NNS cord-010092-uftc8inx 73 30 or or CC cord-010092-uftc8inx 73 31 primary primary JJ cord-010092-uftc8inx 73 32 CML CML NNP cord-010092-uftc8inx 73 33 cells cell NNS cord-010092-uftc8inx 73 34 , , , cord-010092-uftc8inx 73 35 secrete secrete JJ cord-010092-uftc8inx 73 36 pro pro JJ cord-010092-uftc8inx 73 37 - - JJ cord-010092-uftc8inx 73 38 inflammatory inflammatory JJ cord-010092-uftc8inx 73 39 cytokines cytokine NNS cord-010092-uftc8inx 73 40 , , , cord-010092-uftc8inx 73 41 degranulate degranulate JJ cord-010092-uftc8inx 73 42 and and CC cord-010092-uftc8inx 73 43 specifically specifically RB cord-010092-uftc8inx 73 44 killing kill VBG cord-010092-uftc8inx 73 45 them -PRON- PRP cord-010092-uftc8inx 73 46 . . . cord-010092-uftc8inx 74 1 We -PRON- PRP cord-010092-uftc8inx 74 2 also also RB cord-010092-uftc8inx 74 3 demonstrated demonstrate VBD cord-010092-uftc8inx 74 4 that that IN cord-010092-uftc8inx 74 5 multi multi JJ cord-010092-uftc8inx 74 6 - - JJ cord-010092-uftc8inx 74 7 TKIs tkis JJ cord-010092-uftc8inx 74 8 treatment treatment NN cord-010092-uftc8inx 74 9 over over IN cord-010092-uftc8inx 74 10 a a DT cord-010092-uftc8inx 74 11 4-year 4-year CD cord-010092-uftc8inx 74 12 period period NN cord-010092-uftc8inx 74 13 does do VBZ cord-010092-uftc8inx 74 14 not not RB cord-010092-uftc8inx 74 15 affect affect VB cord-010092-uftc8inx 74 16 transduction transduction NN cord-010092-uftc8inx 74 17 efficiency efficiency NN cord-010092-uftc8inx 74 18 of of IN cord-010092-uftc8inx 74 19 CML CML NNP cord-010092-uftc8inx 74 20 patient patient NN cord-010092-uftc8inx 74 21 T T NNP cord-010092-uftc8inx 74 22 - - HYPH cord-010092-uftc8inx 74 23 cells cell NNS cord-010092-uftc8inx 74 24 by by IN cord-010092-uftc8inx 74 25 IL-1RAP IL-1RAP NNP cord-010092-uftc8inx 74 26 CAR CAR NNP cord-010092-uftc8inx 74 27 vector vector NN cord-010092-uftc8inx 74 28 and and CC cord-010092-uftc8inx 74 29 that that IN cord-010092-uftc8inx 74 30 autologous autologous JJ cord-010092-uftc8inx 74 31 CART cart NN cord-010092-uftc8inx 74 32 - - HYPH cord-010092-uftc8inx 74 33 cells cell NNS cord-010092-uftc8inx 74 34 are be VBP cord-010092-uftc8inx 74 35 able able JJ cord-010092-uftc8inx 74 36 to to TO cord-010092-uftc8inx 74 37 target target VB cord-010092-uftc8inx 74 38 IL-1RAP+ IL-1RAP+ NNP cord-010092-uftc8inx 74 39 leukemic leukemic JJ cord-010092-uftc8inx 74 40 primary primary JJ cord-010092-uftc8inx 74 41 HSC HSC NNP cord-010092-uftc8inx 74 42 . . . cord-010092-uftc8inx 74 43 " " '' cord-010092-uftc8inx 75 1 Off off IN cord-010092-uftc8inx 75 2 - - HYPH cord-010092-uftc8inx 75 3 tumor tumor NN cord-010092-uftc8inx 75 4 - - HYPH cord-010092-uftc8inx 75 5 on on RP cord-010092-uftc8inx 75 6 target target NN cord-010092-uftc8inx 75 7 " " '' cord-010092-uftc8inx 75 8 toxicity toxicity NN cord-010092-uftc8inx 75 9 prediction prediction NN cord-010092-uftc8inx 75 10 , , , cord-010092-uftc8inx 75 11 by by IN cord-010092-uftc8inx 75 12 studying study VBG cord-010092-uftc8inx 75 13 IL-1RAP il-1rap JJ cord-010092-uftc8inx 75 14 expression expression NN cord-010092-uftc8inx 75 15 on on IN cord-010092-uftc8inx 75 16 a a DT cord-010092-uftc8inx 75 17 tissue tissue NN cord-010092-uftc8inx 75 18 macroarray macroarray NN cord-010092-uftc8inx 75 19 comprising comprise VBG cord-010092-uftc8inx 75 20 30 30 CD cord-010092-uftc8inx 75 21 normal normal JJ cord-010092-uftc8inx 75 22 human human JJ cord-010092-uftc8inx 75 23 tissues tissue NNS cord-010092-uftc8inx 75 24 ( ( -LRB- cord-010092-uftc8inx 75 25 3 3 CD cord-010092-uftc8inx 75 26 donors donor NNS cord-010092-uftc8inx 75 27 ) ) -RRB- cord-010092-uftc8inx 75 28 , , , cord-010092-uftc8inx 75 29 with with IN cord-010092-uftc8inx 75 30 # # $ cord-010092-uftc8inx 75 31 A3C3 A3C3 NNP cord-010092-uftc8inx 75 32 , , , cord-010092-uftc8inx 75 33 detected detect VBD cord-010092-uftc8inx 75 34 various various JJ cord-010092-uftc8inx 75 35 IL-1RAP il-1rap NN cord-010092-uftc8inx 75 36 intensity intensity NN cord-010092-uftc8inx 75 37 staining stain VBG cord-010092-uftc8inx 75 38 in in IN cord-010092-uftc8inx 75 39 only only JJ cord-010092-uftc8inx 75 40 few few JJ cord-010092-uftc8inx 75 41 tissues tissue NNS cord-010092-uftc8inx 75 42 . . . cord-010092-uftc8inx 76 1 Regarding regard VBG cord-010092-uftc8inx 76 2 the the DT cord-010092-uftc8inx 76 3 healthy healthy JJ cord-010092-uftc8inx 76 4 hematopoietic hematopoietic JJ cord-010092-uftc8inx 76 5 system system NN cord-010092-uftc8inx 76 6 , , , cord-010092-uftc8inx 76 7 # # NN cord-010092-uftc8inx 76 8 A3C3 a3c3 RB cord-010092-uftc8inx 76 9 flow flow NN cord-010092-uftc8inx 76 10 cytometry cytometry NN cord-010092-uftc8inx 76 11 staining staining NN cord-010092-uftc8inx 76 12 did do VBD cord-010092-uftc8inx 76 13 not not RB cord-010092-uftc8inx 76 14 detect detect VB cord-010092-uftc8inx 76 15 hematopoietic hematopoietic JJ cord-010092-uftc8inx 76 16 cells cell NNS cord-010092-uftc8inx 76 17 , , , cord-010092-uftc8inx 76 18 except except IN cord-010092-uftc8inx 76 19 monocytes monocyte NNS cord-010092-uftc8inx 76 20 that that WDT cord-010092-uftc8inx 76 21 express express VBP cord-010092-uftc8inx 76 22 poorly poorly RB cord-010092-uftc8inx 76 23 IL-1RAP IL-1RAP VBN cord-010092-uftc8inx 76 24 . . . cord-010092-uftc8inx 77 1 As as IN cord-010092-uftc8inx 77 2 expected expect VBN cord-010092-uftc8inx 77 3 , , , cord-010092-uftc8inx 77 4 monocyte monocyte NNP cord-010092-uftc8inx 77 5 subpopulation subpopulation NN cord-010092-uftc8inx 77 6 is be VBZ cord-010092-uftc8inx 77 7 targeted target VBN cord-010092-uftc8inx 77 8 by by IN cord-010092-uftc8inx 77 9 autologous autologous JJ cord-010092-uftc8inx 77 10 IL-1RAP IL-1RAP NNP cord-010092-uftc8inx 77 11 CART cart NN cord-010092-uftc8inx 77 12 cells cell NNS cord-010092-uftc8inx 77 13 ( ( -LRB- cord-010092-uftc8inx 77 14 ratio ratio NN cord-010092-uftc8inx 77 15 E e NN cord-010092-uftc8inx 77 16 : : : cord-010092-uftc8inx 77 17 T t NN cord-010092-uftc8inx 77 18 = = SYM cord-010092-uftc8inx 77 19 1:1 1:1 CD cord-010092-uftc8inx 77 20 ) ) -RRB- cord-010092-uftc8inx 77 21 , , , cord-010092-uftc8inx 77 22 but but CC cord-010092-uftc8inx 77 23 at at IN cord-010092-uftc8inx 77 24 a a DT cord-010092-uftc8inx 77 25 lower low JJR cord-010092-uftc8inx 77 26 level level NN cord-010092-uftc8inx 77 27 that that WDT cord-010092-uftc8inx 77 28 IL-1RAP IL-1RAP NNP cord-010092-uftc8inx 77 29 CML CML NNP cord-010092-uftc8inx 77 30 cell cell NN cord-010092-uftc8inx 77 31 line line NN cord-010092-uftc8inx 77 32 . . . cord-010092-uftc8inx 78 1 In in IN cord-010092-uftc8inx 78 2 - - HYPH cord-010092-uftc8inx 78 3 vivo vivo NN cord-010092-uftc8inx 78 4 investigation investigation NN cord-010092-uftc8inx 78 5 of of IN cord-010092-uftc8inx 78 6 specific specific JJ cord-010092-uftc8inx 78 7 toxicities toxicity NNS cord-010092-uftc8inx 78 8 of of IN cord-010092-uftc8inx 78 9 autologous autologous JJ cord-010092-uftc8inx 78 10 IL-1RAP IL-1RAP NNP cord-010092-uftc8inx 78 11 CART cart NN cord-010092-uftc8inx 78 12 - - HYPH cord-010092-uftc8inx 78 13 cells cell NNS cord-010092-uftc8inx 78 14 against against IN cord-010092-uftc8inx 78 15 HSC HSC NNP cord-010092-uftc8inx 78 16 and/or and/or CC cord-010092-uftc8inx 78 17 immune immune JJ cord-010092-uftc8inx 78 18 cells cell NNS cord-010092-uftc8inx 78 19 on on IN cord-010092-uftc8inx 78 20 a a DT cord-010092-uftc8inx 78 21 human human NN cord-010092-uftc8inx 78 22 - - HYPH cord-010092-uftc8inx 78 23 CD34 CD34 NNP cord-010092-uftc8inx 78 24 + + CC cord-010092-uftc8inx 78 25 cord cord NN cord-010092-uftc8inx 78 26 blood blood NN cord-010092-uftc8inx 78 27 cell cell NN cord-010092-uftc8inx 78 28 engrafted engraft VBD cord-010092-uftc8inx 78 29 / / SYM cord-010092-uftc8inx 78 30 NOG NOG NNP cord-010092-uftc8inx 78 31 murine murine JJ cord-010092-uftc8inx 78 32 model model NN cord-010092-uftc8inx 78 33 , , , cord-010092-uftc8inx 78 34 but but CC cord-010092-uftc8inx 78 35 also also RB cord-010092-uftc8inx 78 36 by by IN cord-010092-uftc8inx 78 37 an an DT cord-010092-uftc8inx 78 38 in in IN cord-010092-uftc8inx 78 39 - - HYPH cord-010092-uftc8inx 78 40 vitro vitro FW cord-010092-uftc8inx 78 41 CD34 CD34 NNP cord-010092-uftc8inx 78 42 + + CC cord-010092-uftc8inx 78 43 colony colony NN cord-010092-uftc8inx 78 44 forming form VBG cord-010092-uftc8inx 78 45 unit unit NN cord-010092-uftc8inx 78 46 assay assay NN cord-010092-uftc8inx 78 47 did do VBD cord-010092-uftc8inx 78 48 n't not RB cord-010092-uftc8inx 78 49 reveal reveal VB cord-010092-uftc8inx 78 50 any any DT cord-010092-uftc8inx 78 51 significant significant JJ cord-010092-uftc8inx 78 52 toxicities toxicity NNS cord-010092-uftc8inx 78 53 in in IN cord-010092-uftc8inx 78 54 immunocompetent immunocompetent JJ cord-010092-uftc8inx 78 55 cell cell NN cord-010092-uftc8inx 78 56 subpopulations subpopulation NNS cord-010092-uftc8inx 78 57 , , , cord-010092-uftc8inx 78 58 suggesting suggest VBG cord-010092-uftc8inx 78 59 that that IN cord-010092-uftc8inx 78 60 healthy healthy JJ cord-010092-uftc8inx 78 61 CD34 CD34 NNP cord-010092-uftc8inx 78 62 + + SYM cord-010092-uftc8inx 78 63 HSC HSC NNP cord-010092-uftc8inx 78 64 are be VBP cord-010092-uftc8inx 78 65 not not RB cord-010092-uftc8inx 78 66 affected affect VBN cord-010092-uftc8inx 78 67 . . . cord-010092-uftc8inx 79 1 Finally finally RB cord-010092-uftc8inx 79 2 , , , cord-010092-uftc8inx 79 3 to to TO cord-010092-uftc8inx 79 4 overcome overcome VB cord-010092-uftc8inx 79 5 potential potential JJ cord-010092-uftc8inx 79 6 toxicity toxicity NN cord-010092-uftc8inx 79 7 , , , cord-010092-uftc8inx 79 8 functionality functionality NN cord-010092-uftc8inx 79 9 of of IN cord-010092-uftc8inx 79 10 the the DT cord-010092-uftc8inx 79 11 iCASP9/ iCASP9/ NNPS cord-010092-uftc8inx 79 12 Rimiducid Rimiducid NNP cord-010092-uftc8inx 79 13 â â NNP cord-010092-uftc8inx 79 14 safety safety NN cord-010092-uftc8inx 79 15 switch switch NN cord-010092-uftc8inx 79 16 was be VBD cord-010092-uftc8inx 79 17 demonstrated demonstrate VBN cord-010092-uftc8inx 79 18 in in IN cord-010092-uftc8inx 79 19 - - HYPH cord-010092-uftc8inx 79 20 vitro vitro FW cord-010092-uftc8inx 79 21 but but CC cord-010092-uftc8inx 79 22 also also RB cord-010092-uftc8inx 80 1 in in IN cord-010092-uftc8inx 80 2 - - HYPH cord-010092-uftc8inx 80 3 vivo vivo NN cord-010092-uftc8inx 80 4 in in IN cord-010092-uftc8inx 80 5 a a DT cord-010092-uftc8inx 80 6 NSG NSG NNP cord-010092-uftc8inx 80 7 tumor tumor NN cord-010092-uftc8inx 80 8 xenograft xenograft NN cord-010092-uftc8inx 80 9 model model NN cord-010092-uftc8inx 80 10 , , , cord-010092-uftc8inx 80 11 showing show VBG cord-010092-uftc8inx 80 12 that that IN cord-010092-uftc8inx 80 13 , , , cord-010092-uftc8inx 80 14 when when WRB cord-010092-uftc8inx 80 15 activate activate VBP cord-010092-uftc8inx 80 16 , , , cord-010092-uftc8inx 80 17 the the DT cord-010092-uftc8inx 80 18 system system NN cord-010092-uftc8inx 80 19 is be VBZ cord-010092-uftc8inx 80 20 able able JJ cord-010092-uftc8inx 80 21 to to TO cord-010092-uftc8inx 80 22 eliminate eliminate VB cord-010092-uftc8inx 80 23 more more JJR cord-010092-uftc8inx 80 24 than than IN cord-010092-uftc8inx 80 25 90 90 CD cord-010092-uftc8inx 80 26 % % NN cord-010092-uftc8inx 80 27 of of IN cord-010092-uftc8inx 80 28 CART cart NN cord-010092-uftc8inx 80 29 - - HYPH cord-010092-uftc8inx 80 30 cells cell NNS cord-010092-uftc8inx 80 31 , , , cord-010092-uftc8inx 80 32 after after IN cord-010092-uftc8inx 80 33 exposure exposure NN cord-010092-uftc8inx 80 34 to to IN cord-010092-uftc8inx 80 35 AP1903 ap1903 NN cord-010092-uftc8inx 80 36 . . . cord-010092-uftc8inx 81 1 In in IN cord-010092-uftc8inx 81 2 conclusion conclusion NN cord-010092-uftc8inx 81 3 , , , cord-010092-uftc8inx 81 4 based base VBN cord-010092-uftc8inx 81 5 on on IN cord-010092-uftc8inx 81 6 CML CML NNP cord-010092-uftc8inx 81 7 model model NN cord-010092-uftc8inx 81 8 , , , cord-010092-uftc8inx 81 9 we -PRON- PRP cord-010092-uftc8inx 81 10 demonstrated demonstrate VBD cord-010092-uftc8inx 81 11 that that IN cord-010092-uftc8inx 81 12 IL-1RAP IL-1RAP NNP cord-010092-uftc8inx 81 13 is be VBZ cord-010092-uftc8inx 81 14 an an DT cord-010092-uftc8inx 81 15 interesting interesting JJ cord-010092-uftc8inx 81 16 target target NN cord-010092-uftc8inx 81 17 for for IN cord-010092-uftc8inx 81 18 CART cart NN cord-010092-uftc8inx 81 19 - - HYPH cord-010092-uftc8inx 81 20 cell cell NN cord-010092-uftc8inx 81 21 immunotherapy immunotherapy NN cord-010092-uftc8inx 81 22 , , , cord-010092-uftc8inx 81 23 with with IN cord-010092-uftc8inx 81 24 a a DT cord-010092-uftc8inx 81 25 limited limited JJ cord-010092-uftc8inx 81 26 " " '' cord-010092-uftc8inx 81 27 on on IN cord-010092-uftc8inx 81 28 target target NN cord-010092-uftc8inx 81 29 , , , cord-010092-uftc8inx 81 30 off off IN cord-010092-uftc8inx 81 31 tumor tumor NN cord-010092-uftc8inx 81 32 " " `` cord-010092-uftc8inx 81 33 predictable predictable JJ cord-010092-uftc8inx 81 34 toxicity toxicity NN cord-010092-uftc8inx 81 35 . . . cord-010092-uftc8inx 82 1 Next next JJ cord-010092-uftc8inx 82 2 step step NN cord-010092-uftc8inx 82 3 will will MD cord-010092-uftc8inx 82 4 be be VB cord-010092-uftc8inx 82 5 the the DT cord-010092-uftc8inx 82 6 up up RB cord-010092-uftc8inx 82 7 - - HYPH cord-010092-uftc8inx 82 8 scaling scaling NN cord-010092-uftc8inx 82 9 of of IN cord-010092-uftc8inx 82 10 the the DT cord-010092-uftc8inx 82 11 process process NN cord-010092-uftc8inx 82 12 in in IN cord-010092-uftc8inx 82 13 order order NN cord-010092-uftc8inx 82 14 to to TO cord-010092-uftc8inx 82 15 match match VB cord-010092-uftc8inx 82 16 with with IN cord-010092-uftc8inx 82 17 the the DT cord-010092-uftc8inx 82 18 use use NN cord-010092-uftc8inx 82 19 in in IN cord-010092-uftc8inx 82 20 human human JJ cord-010092-uftc8inx 82 21 regarding regarding NN cord-010092-uftc8inx 82 22 also also RB cord-010092-uftc8inx 82 23 the the DT cord-010092-uftc8inx 82 24 regulatory regulatory JJ cord-010092-uftc8inx 82 25 requirements requirement NNS cord-010092-uftc8inx 82 26 . . . cord-010092-uftc8inx 83 1 This this DT cord-010092-uftc8inx 83 2 strategy strategy NN cord-010092-uftc8inx 83 3 may may MD cord-010092-uftc8inx 83 4 be be VB cord-010092-uftc8inx 83 5 applied apply VBN cord-010092-uftc8inx 83 6 , , , cord-010092-uftc8inx 83 7 in in IN cord-010092-uftc8inx 83 8 the the DT cord-010092-uftc8inx 83 9 future future NN cord-010092-uftc8inx 83 10 , , , cord-010092-uftc8inx 83 11 in in IN cord-010092-uftc8inx 83 12 other other JJ cord-010092-uftc8inx 83 13 hematological hematological JJ cord-010092-uftc8inx 83 14 malignancies malignancy NNS cord-010092-uftc8inx 83 15 . . . cord-010092-uftc8inx 84 1 Mortality mortality NN cord-010092-uftc8inx 84 2 ranges range VBZ cord-010092-uftc8inx 84 3 from from IN cord-010092-uftc8inx 84 4 20 20 CD cord-010092-uftc8inx 84 5 to to TO cord-010092-uftc8inx 84 6 30 30 CD cord-010092-uftc8inx 84 7 % % NN cord-010092-uftc8inx 84 8 for for IN cord-010092-uftc8inx 84 9 trauma trauma NN cord-010092-uftc8inx 84 10 victims victim NNS cord-010092-uftc8inx 84 11 with with IN cord-010092-uftc8inx 84 12 severe severe JJ cord-010092-uftc8inx 84 13 bleeding bleeding NN cord-010092-uftc8inx 84 14 and and CC cord-010092-uftc8inx 84 15 is be VBZ cord-010092-uftc8inx 84 16 largely largely RB cord-010092-uftc8inx 84 17 dependent dependent JJ cord-010092-uftc8inx 84 18 on on IN cord-010092-uftc8inx 84 19 the the DT cord-010092-uftc8inx 84 20 transfusion transfusion NN cord-010092-uftc8inx 84 21 therapy therapy NN cord-010092-uftc8inx 84 22 from from IN cord-010092-uftc8inx 84 23 which which WDT cord-010092-uftc8inx 84 24 they -PRON- PRP cord-010092-uftc8inx 84 25 can can MD cord-010092-uftc8inx 84 26 benefit benefit VB cord-010092-uftc8inx 84 27 . . . cord-010092-uftc8inx 85 1 The the DT cord-010092-uftc8inx 85 2 nature nature NN cord-010092-uftc8inx 85 3 of of IN cord-010092-uftc8inx 85 4 this this DT cord-010092-uftc8inx 85 5 therapy therapy NN cord-010092-uftc8inx 85 6 has have VBZ cord-010092-uftc8inx 85 7 an an DT cord-010092-uftc8inx 85 8 impact impact NN cord-010092-uftc8inx 85 9 on on IN cord-010092-uftc8inx 85 10 prognosis prognosis NN cord-010092-uftc8inx 85 11 with with IN cord-010092-uftc8inx 85 12 a a DT cord-010092-uftc8inx 85 13 halving halving NN cord-010092-uftc8inx 85 14 of of IN cord-010092-uftc8inx 85 15 mortality mortality NN cord-010092-uftc8inx 85 16 when when WRB cord-010092-uftc8inx 85 17 the the DT cord-010092-uftc8inx 85 18 plasma plasma NN cord-010092-uftc8inx 85 19 / / SYM cord-010092-uftc8inx 85 20 pRBC prbc NN cord-010092-uftc8inx 85 21 ratio ratio NN cord-010092-uftc8inx 85 22 is be VBZ cord-010092-uftc8inx 85 23 greater great JJR cord-010092-uftc8inx 85 24 than than IN cord-010092-uftc8inx 85 25 ½ ½ NN cord-010092-uftc8inx 85 26 and and CC cord-010092-uftc8inx 85 27 a a DT cord-010092-uftc8inx 85 28 decrease decrease NN cord-010092-uftc8inx 85 29 of of IN cord-010092-uftc8inx 85 30 about about IN cord-010092-uftc8inx 85 31 20 20 CD cord-010092-uftc8inx 85 32 % % NN cord-010092-uftc8inx 85 33 when when WRB cord-010092-uftc8inx 85 34 the the DT cord-010092-uftc8inx 85 35 proportion proportion NN cord-010092-uftc8inx 85 36 of of IN cord-010092-uftc8inx 85 37 platelets platelet NNS cord-010092-uftc8inx 85 38 transfused transfuse VBN cord-010092-uftc8inx 85 39 is be VBZ cord-010092-uftc8inx 85 40 close close JJ cord-010092-uftc8inx 85 41 to to IN cord-010092-uftc8inx 85 42 that that DT cord-010092-uftc8inx 85 43 of of IN cord-010092-uftc8inx 85 44 whole whole JJ cord-010092-uftc8inx 85 45 blood blood NN cord-010092-uftc8inx 85 46 . . . cord-010092-uftc8inx 86 1 The the DT cord-010092-uftc8inx 86 2 speed speed NN cord-010092-uftc8inx 86 3 with with IN cord-010092-uftc8inx 86 4 which which WDT cord-010092-uftc8inx 86 5 such such JJ cord-010092-uftc8inx 86 6 therapy therapy NN cord-010092-uftc8inx 86 7 is be VBZ cord-010092-uftc8inx 86 8 actually actually RB cord-010092-uftc8inx 86 9 administered administer VBN cord-010092-uftc8inx 86 10 has have VBZ cord-010092-uftc8inx 86 11 a a DT cord-010092-uftc8inx 86 12 major major JJ cord-010092-uftc8inx 86 13 impact impact NN cord-010092-uftc8inx 86 14 as as RB cord-010092-uftc8inx 86 15 well well RB cord-010092-uftc8inx 86 16 with with IN cord-010092-uftc8inx 86 17 an an DT cord-010092-uftc8inx 86 18 increase increase NN cord-010092-uftc8inx 86 19 in in IN cord-010092-uftc8inx 86 20 mortality mortality NN cord-010092-uftc8inx 86 21 of of IN cord-010092-uftc8inx 86 22 5 5 CD cord-010092-uftc8inx 86 23 % % NN cord-010092-uftc8inx 86 24 for for IN cord-010092-uftc8inx 86 25 each each DT cord-010092-uftc8inx 86 26 minute minute NN cord-010092-uftc8inx 86 27 of of IN cord-010092-uftc8inx 86 28 delay delay NN cord-010092-uftc8inx 86 29 in in IN cord-010092-uftc8inx 86 30 making make VBG cord-010092-uftc8inx 86 31 the the DT cord-010092-uftc8inx 86 32 entire entire JJ cord-010092-uftc8inx 86 33 therapy therapy NN cord-010092-uftc8inx 86 34 available available JJ cord-010092-uftc8inx 86 35 . . . cord-010092-uftc8inx 87 1 This this DT cord-010092-uftc8inx 87 2 can can MD cord-010092-uftc8inx 87 3 be be VB cord-010092-uftc8inx 87 4 explained explain VBN cord-010092-uftc8inx 87 5 mainly mainly RB cord-010092-uftc8inx 87 6 by by IN cord-010092-uftc8inx 87 7 the the DT cord-010092-uftc8inx 87 8 fact fact NN cord-010092-uftc8inx 87 9 that that IN cord-010092-uftc8inx 87 10 the the DT cord-010092-uftc8inx 87 11 probability probability NN cord-010092-uftc8inx 87 12 of of IN cord-010092-uftc8inx 87 13 death death NN cord-010092-uftc8inx 87 14 of of IN cord-010092-uftc8inx 87 15 these these DT cord-010092-uftc8inx 87 16 patients patient NNS cord-010092-uftc8inx 87 17 is be VBZ cord-010092-uftc8inx 87 18 greater great JJR cord-010092-uftc8inx 87 19 within within IN cord-010092-uftc8inx 87 20 minutes minute NNS cord-010092-uftc8inx 87 21 of of IN cord-010092-uftc8inx 87 22 their -PRON- PRP$ cord-010092-uftc8inx 87 23 admission admission NN cord-010092-uftc8inx 87 24 to to IN cord-010092-uftc8inx 87 25 hospital hospital NN cord-010092-uftc8inx 87 26 with with IN cord-010092-uftc8inx 87 27 a a DT cord-010092-uftc8inx 87 28 median median JJ cord-010092-uftc8inx 87 29 time time NN cord-010092-uftc8inx 87 30 to to IN cord-010092-uftc8inx 87 31 death death NN cord-010092-uftc8inx 87 32 of of IN cord-010092-uftc8inx 87 33 2 2 CD cord-010092-uftc8inx 87 34 h h NN cord-010092-uftc8inx 87 35 after after IN cord-010092-uftc8inx 87 36 admission admission NN cord-010092-uftc8inx 87 37 . . . cord-010092-uftc8inx 88 1 To to TO cord-010092-uftc8inx 88 2 allow allow VB cord-010092-uftc8inx 88 3 plasma plasma NN cord-010092-uftc8inx 88 4 , , , cord-010092-uftc8inx 88 5 platelets platelet NNS cord-010092-uftc8inx 88 6 and and CC cord-010092-uftc8inx 88 7 pRBC pRBC VBZ cord-010092-uftc8inx 88 8 to to TO cord-010092-uftc8inx 88 9 be be VB cord-010092-uftc8inx 88 10 made make VBN cord-010092-uftc8inx 88 11 available available JJ cord-010092-uftc8inx 88 12 in in IN cord-010092-uftc8inx 88 13 a a DT cord-010092-uftc8inx 88 14 timely timely JJ cord-010092-uftc8inx 88 15 manner manner NN cord-010092-uftc8inx 88 16 , , , cord-010092-uftc8inx 88 17 North north JJ cord-010092-uftc8inx 88 18 American american JJ cord-010092-uftc8inx 88 19 trauma trauma NN cord-010092-uftc8inx 88 20 centers center NNS cord-010092-uftc8inx 88 21 have have VBP cord-010092-uftc8inx 88 22 mandated mandate VBN cord-010092-uftc8inx 88 23 that that IN cord-010092-uftc8inx 88 24 trauma trauma NN cord-010092-uftc8inx 88 25 centers center NNS cord-010092-uftc8inx 88 26 have have VBP cord-010092-uftc8inx 88 27 massive massive JJ cord-010092-uftc8inx 88 28 transfusion transfusion NN cord-010092-uftc8inx 88 29 packs pack NNS cord-010092-uftc8inx 88 30 at at IN cord-010092-uftc8inx 88 31 the the DT cord-010092-uftc8inx 88 32 patient patient NN cord-010092-uftc8inx 88 33 's 's POS cord-010092-uftc8inx 88 34 bedside bedside NN cord-010092-uftc8inx 88 35 within within IN cord-010092-uftc8inx 88 36 15 15 CD cord-010092-uftc8inx 88 37 min min NN cord-010092-uftc8inx 88 38 . . . cord-010092-uftc8inx 89 1 To to TO cord-010092-uftc8inx 89 2 further further RB cord-010092-uftc8inx 89 3 simplify simplify VB cord-010092-uftc8inx 89 4 and and CC cord-010092-uftc8inx 89 5 speed speed VB cord-010092-uftc8inx 89 6 up up RP cord-010092-uftc8inx 89 7 logistics logistic NNS cord-010092-uftc8inx 89 8 from from IN cord-010092-uftc8inx 89 9 distribution distribution NN cord-010092-uftc8inx 89 10 to to IN cord-010092-uftc8inx 89 11 transfusion transfusion NN cord-010092-uftc8inx 89 12 , , , cord-010092-uftc8inx 89 13 several several JJ cord-010092-uftc8inx 89 14 trauma trauma NN cord-010092-uftc8inx 89 15 centers center NNS cord-010092-uftc8inx 89 16 now now RB cord-010092-uftc8inx 89 17 use use VBP cord-010092-uftc8inx 89 18 whole whole JJ cord-010092-uftc8inx 89 19 blood blood NN cord-010092-uftc8inx 89 20 stored store VBN cord-010092-uftc8inx 89 21 at at IN cord-010092-uftc8inx 89 22 4 4 CD cord-010092-uftc8inx 89 23 ° ° NN cord-010092-uftc8inx 89 24 C c NN cord-010092-uftc8inx 89 25 . . . cord-010092-uftc8inx 90 1 This this DT cord-010092-uftc8inx 90 2 return return NN cord-010092-uftc8inx 90 3 of of IN cord-010092-uftc8inx 90 4 an an DT cord-010092-uftc8inx 90 5 " " `` cord-010092-uftc8inx 90 6 old old JJ cord-010092-uftc8inx 90 7 " " '' cord-010092-uftc8inx 90 8 product product NN cord-010092-uftc8inx 90 9 is be VBZ cord-010092-uftc8inx 90 10 largely largely RB cord-010092-uftc8inx 90 11 inspired inspire VBN cord-010092-uftc8inx 90 12 by by IN cord-010092-uftc8inx 90 13 military military JJ cord-010092-uftc8inx 90 14 experience experience NN cord-010092-uftc8inx 90 15 where where WRB cord-010092-uftc8inx 90 16 whole whole JJ cord-010092-uftc8inx 90 17 blood blood NN cord-010092-uftc8inx 90 18 is be VBZ cord-010092-uftc8inx 90 19 mainly mainly RB cord-010092-uftc8inx 90 20 used use VBN cord-010092-uftc8inx 90 21 " " `` cord-010092-uftc8inx 90 22 warm warm JJ cord-010092-uftc8inx 90 23 " " '' cord-010092-uftc8inx 90 24 immediately immediately RB cord-010092-uftc8inx 90 25 after after IN cord-010092-uftc8inx 90 26 collection collection NN cord-010092-uftc8inx 90 27 with with IN cord-010092-uftc8inx 90 28 compelling compelling JJ cord-010092-uftc8inx 90 29 evidence evidence NN cord-010092-uftc8inx 90 30 of of IN cord-010092-uftc8inx 90 31 its -PRON- PRP$ cord-010092-uftc8inx 90 32 effectiveness effectiveness NN cord-010092-uftc8inx 90 33 . . . cord-010092-uftc8inx 91 1 Its -PRON- PRP$ cord-010092-uftc8inx 91 2 return return NN cord-010092-uftc8inx 91 3 to to IN cord-010092-uftc8inx 91 4 civilian civilian JJ cord-010092-uftc8inx 91 5 practice practice NN cord-010092-uftc8inx 91 6 requires require VBZ cord-010092-uftc8inx 91 7 the the DT cord-010092-uftc8inx 91 8 ability ability NN cord-010092-uftc8inx 91 9 to to TO cord-010092-uftc8inx 91 10 deleukocyte deleukocyte VB cord-010092-uftc8inx 91 11 it -PRON- PRP cord-010092-uftc8inx 91 12 while while IN cord-010092-uftc8inx 91 13 preserving preserve VBG cord-010092-uftc8inx 91 14 platelets platelet NNS cord-010092-uftc8inx 91 15 and and CC cord-010092-uftc8inx 91 16 to to TO cord-010092-uftc8inx 91 17 store store VB cord-010092-uftc8inx 91 18 it -PRON- PRP cord-010092-uftc8inx 91 19 while while IN cord-010092-uftc8inx 91 20 maintaining maintain VBG cord-010092-uftc8inx 91 21 their -PRON- PRP$ cord-010092-uftc8inx 91 22 hemostatic hemostatic JJ cord-010092-uftc8inx 91 23 functions function NNS cord-010092-uftc8inx 91 24 . . . cord-010092-uftc8inx 92 1 Good good JJ cord-010092-uftc8inx 92 2 quality quality NN cord-010092-uftc8inx 92 3 data datum NNS cord-010092-uftc8inx 92 4 shows show VBZ cord-010092-uftc8inx 92 5 this this DT cord-010092-uftc8inx 92 6 is be VBZ cord-010092-uftc8inx 92 7 achievable achievable JJ cord-010092-uftc8inx 92 8 and and CC cord-010092-uftc8inx 92 9 several several JJ cord-010092-uftc8inx 92 10 clinical clinical JJ cord-010092-uftc8inx 92 11 studies study NNS cord-010092-uftc8inx 92 12 are be VBP cord-010092-uftc8inx 92 13 planned plan VBN cord-010092-uftc8inx 92 14 to to TO cord-010092-uftc8inx 92 15 begin begin VB cord-010092-uftc8inx 92 16 in in IN cord-010092-uftc8inx 92 17 the the DT cord-010092-uftc8inx 92 18 coming come VBG cord-010092-uftc8inx 92 19 months month NNS cord-010092-uftc8inx 92 20 . . . cord-010092-uftc8inx 93 1 In in IN cord-010092-uftc8inx 93 2 France France NNP cord-010092-uftc8inx 93 3 , , , cord-010092-uftc8inx 93 4 the the DT cord-010092-uftc8inx 93 5 French French NNP cord-010092-uftc8inx 93 6 Blood Blood NNP cord-010092-uftc8inx 93 7 Establishment Establishment NNP cord-010092-uftc8inx 93 8 and and CC cord-010092-uftc8inx 93 9 the the DT cord-010092-uftc8inx 93 10 French french JJ cord-010092-uftc8inx 93 11 Army Army NNP cord-010092-uftc8inx 93 12 are be VBP cord-010092-uftc8inx 93 13 cooperating cooperate VBG cord-010092-uftc8inx 93 14 to to TO cord-010092-uftc8inx 93 15 initiate initiate VB cord-010092-uftc8inx 93 16 the the DT cord-010092-uftc8inx 93 17 prospective prospective JJ cord-010092-uftc8inx 93 18 randomized randomized JJ cord-010092-uftc8inx 93 19 non non JJ cord-010092-uftc8inx 93 20 - - JJ cord-010092-uftc8inx 93 21 inferiority inferiority JJ cord-010092-uftc8inx 93 22 STORHM STORHM NNP cord-010092-uftc8inx 93 23 trial trial NN cord-010092-uftc8inx 93 24 ( ( -LRB- cord-010092-uftc8inx 93 25 Sang Sang NNP cord-010092-uftc8inx 93 26 Total Total NNP cord-010092-uftc8inx 93 27 pour pour NN cord-010092-uftc8inx 93 28 la la FW cord-010092-uftc8inx 93 29 R r NN cord-010092-uftc8inx 94 1 eanimation eanimation NNP cord-010092-uftc8inx 94 2 des des NNP cord-010092-uftc8inx 94 3 H H NNP cord-010092-uftc8inx 94 4 emorragies emorragies NNPS cord-010092-uftc8inx 94 5 Massives Massives NNP cord-010092-uftc8inx 94 6 ) ) -RRB- cord-010092-uftc8inx 94 7 which which WDT cord-010092-uftc8inx 94 8 will will MD cord-010092-uftc8inx 94 9 be be VB cord-010092-uftc8inx 94 10 comparing compare VBG cord-010092-uftc8inx 94 11 whole whole JJ cord-010092-uftc8inx 94 12 blood blood NN cord-010092-uftc8inx 94 13 to to TO cord-010092-uftc8inx 94 14 separate separate VB cord-010092-uftc8inx 94 15 blood blood NN cord-010092-uftc8inx 94 16 components component NNS cord-010092-uftc8inx 94 17 in in IN cord-010092-uftc8inx 94 18 an an DT cord-010092-uftc8inx 94 19 1/1/1 1/1/1 CD cord-010092-uftc8inx 94 20 ratio ratio NN cord-010092-uftc8inx 94 21 in in IN cord-010092-uftc8inx 94 22 severely severely RB cord-010092-uftc8inx 94 23 bleeding bleed VBG cord-010092-uftc8inx 94 24 trauma trauma NN cord-010092-uftc8inx 94 25 patients patient NNS cord-010092-uftc8inx 94 26 . . . cord-010092-uftc8inx 95 1 The the DT cord-010092-uftc8inx 95 2 primary primary JJ cord-010092-uftc8inx 95 3 endpoint endpoint NN cord-010092-uftc8inx 95 4 will will MD cord-010092-uftc8inx 95 5 be be VB cord-010092-uftc8inx 95 6 a a DT cord-010092-uftc8inx 95 7 thromboelastographic thromboelastographic JJ cord-010092-uftc8inx 95 8 parameter parameter NN cord-010092-uftc8inx 95 9 ( ( -LRB- cord-010092-uftc8inx 95 10 maximum maximum JJ cord-010092-uftc8inx 95 11 amplitude amplitude NN cord-010092-uftc8inx 95 12 ) ) -RRB- cord-010092-uftc8inx 95 13 assessed assess VBN cord-010092-uftc8inx 95 14 at at IN cord-010092-uftc8inx 95 15 the the DT cord-010092-uftc8inx 95 16 6th 6th JJ cord-010092-uftc8inx 95 17 hour hour NN cord-010092-uftc8inx 95 18 after after IN cord-010092-uftc8inx 95 19 admission admission NN cord-010092-uftc8inx 95 20 . . . cord-010092-uftc8inx 96 1 Secondary secondary JJ cord-010092-uftc8inx 96 2 endpoints endpoint NNS cord-010092-uftc8inx 96 3 will will MD cord-010092-uftc8inx 96 4 include include VB cord-010092-uftc8inx 96 5 early early JJ cord-010092-uftc8inx 96 6 and and CC cord-010092-uftc8inx 96 7 overall overall JJ cord-010092-uftc8inx 96 8 mortality mortality NN cord-010092-uftc8inx 96 9 , , , cord-010092-uftc8inx 96 10 lactate lactate NN cord-010092-uftc8inx 96 11 clearance clearance NN cord-010092-uftc8inx 96 12 ( ( -LRB- cord-010092-uftc8inx 96 13 reflection reflection NN cord-010092-uftc8inx 96 14 of of IN cord-010092-uftc8inx 96 15 the the DT cord-010092-uftc8inx 96 16 effectiveness effectiveness NN cord-010092-uftc8inx 96 17 of of IN cord-010092-uftc8inx 96 18 resuscitation resuscitation NN cord-010092-uftc8inx 96 19 ) ) -RRB- cord-010092-uftc8inx 96 20 and and CC cord-010092-uftc8inx 96 21 24 24 CD cord-010092-uftc8inx 96 22 h h NN cord-010092-uftc8inx 96 23 organ organ NN cord-010092-uftc8inx 96 24 failure failure NN cord-010092-uftc8inx 96 25 . . . cord-010092-uftc8inx 97 1 This this DT cord-010092-uftc8inx 97 2 trial trial NN cord-010092-uftc8inx 97 3 will will MD cord-010092-uftc8inx 97 4 be be VB cord-010092-uftc8inx 97 5 recruiting recruit VBG cord-010092-uftc8inx 97 6 200 200 CD cord-010092-uftc8inx 97 7 patients patient NNS cord-010092-uftc8inx 97 8 in in IN cord-010092-uftc8inx 97 9 6 6 CD cord-010092-uftc8inx 97 10 French french JJ cord-010092-uftc8inx 97 11 trauma trauma NN cord-010092-uftc8inx 97 12 centers center NNS cord-010092-uftc8inx 97 13 and and CC cord-010092-uftc8inx 97 14 is be VBZ cord-010092-uftc8inx 97 15 planned plan VBN cord-010092-uftc8inx 97 16 to to TO cord-010092-uftc8inx 97 17 be be VB cord-010092-uftc8inx 97 18 initiated initiate VBN cord-010092-uftc8inx 97 19 second second JJ cord-010092-uftc8inx 97 20 half half NN cord-010092-uftc8inx 97 21 of of IN cord-010092-uftc8inx 97 22 2019 2019 CD cord-010092-uftc8inx 97 23 . . . cord-010092-uftc8inx 98 1 Local local JJ cord-010092-uftc8inx 98 2 / / SYM cord-010092-uftc8inx 98 3 Neighbours Neighbours NNP cord-010092-uftc8inx 98 4 Day Day NNP cord-010092-uftc8inx 99 1 : : : cord-010092-uftc8inx 99 2 Innovation innovation NN cord-010092-uftc8inx 99 3 in in IN cord-010092-uftc8inx 99 4 Germany Germany NNP cord-010092-uftc8inx 99 5 1C-03 1c-03 CD cord-010092-uftc8inx 99 6 - - HYPH cord-010092-uftc8inx 99 7 01 01 CD cord-010092-uftc8inx 99 8 MESENCHYMAL MESENCHYMAL NNP cord-010092-uftc8inx 99 9 STROMAL STROMAL NNP cord-010092-uftc8inx 99 10 CELLS cell NNS cord-010092-uftc8inx 99 11 FOR for IN cord-010092-uftc8inx 99 12 REGENERATIVE regenerative JJ cord-010092-uftc8inx 99 13 THERAPY therapy NN cord-010092-uftc8inx 99 14 BM BM NNP cord-010092-uftc8inx 99 15 - - HYPH cord-010092-uftc8inx 99 16 MSC MSC NNP cord-010092-uftc8inx 99 17 / / SYM cord-010092-uftc8inx 99 18 ASC ASC NNP cord-010092-uftc8inx 99 19 obtained obtain VBD cord-010092-uftc8inx 99 20 from from IN cord-010092-uftc8inx 99 21 these these DT cord-010092-uftc8inx 99 22 protocols protocol NNS cord-010092-uftc8inx 99 23 have have VBP cord-010092-uftc8inx 99 24 been be VBN cord-010092-uftc8inx 99 25 characterized characterize VBN cord-010092-uftc8inx 99 26 in in IN cord-010092-uftc8inx 99 27 detail detail NN cord-010092-uftc8inx 99 28 in in IN cord-010092-uftc8inx 99 29 preclinical preclinical JJ cord-010092-uftc8inx 99 30 evaluations evaluation NNS cord-010092-uftc8inx 99 31 . . . cord-010092-uftc8inx 100 1 Manufacturing manufacturing NN cord-010092-uftc8inx 100 2 licenses license NNS cord-010092-uftc8inx 100 3 for for IN cord-010092-uftc8inx 100 4 MSC MSC NNP cord-010092-uftc8inx 100 5 and and CC cord-010092-uftc8inx 100 6 ASC ASC NNP cord-010092-uftc8inx 100 7 and and CC cord-010092-uftc8inx 100 8 a a DT cord-010092-uftc8inx 100 9 platelet platelet NN cord-010092-uftc8inx 100 10 - - HYPH cord-010092-uftc8inx 100 11 derived derive VBN cord-010092-uftc8inx 100 12 growth growth NN cord-010092-uftc8inx 100 13 factor factor NN cord-010092-uftc8inx 100 14 concentrate concentrate NN cord-010092-uftc8inx 100 15 have have VBP cord-010092-uftc8inx 100 16 been be VBN cord-010092-uftc8inx 100 17 obtained obtain VBN cord-010092-uftc8inx 100 18 and and CC cord-010092-uftc8inx 100 19 they -PRON- PRP cord-010092-uftc8inx 100 20 have have VBP cord-010092-uftc8inx 100 21 been be VBN cord-010092-uftc8inx 100 22 explored explore VBN cord-010092-uftc8inx 100 23 in in IN cord-010092-uftc8inx 100 24 several several JJ cord-010092-uftc8inx 100 25 clinical clinical JJ cord-010092-uftc8inx 100 26 trials trial NNS cord-010092-uftc8inx 100 27 for for IN cord-010092-uftc8inx 100 28 treatment treatment NN cord-010092-uftc8inx 100 29 of of IN cord-010092-uftc8inx 100 30 bone bone NN cord-010092-uftc8inx 100 31 defects defect NNS cord-010092-uftc8inx 101 1 ( ( -LRB- cord-010092-uftc8inx 101 2 ORTHO ORTHO NNP cord-010092-uftc8inx 101 3 - - HYPH cord-010092-uftc8inx 101 4 CT1 CT1 NNP cord-010092-uftc8inx 101 5 : : : cord-010092-uftc8inx 101 6 EudraCT EudraCT NNP cord-010092-uftc8inx 101 7 Number Number NNP cord-010092-uftc8inx 101 8 : : : cord-010092-uftc8inx 101 9 2011 2011 CD cord-010092-uftc8inx 101 10 - - HYPH cord-010092-uftc8inx 101 11 005441 005441 CD cord-010092-uftc8inx 101 12 - - SYM cord-010092-uftc8inx 101 13 13 13 CD cord-010092-uftc8inx 101 14 ; ; : cord-010092-uftc8inx 101 15 ORTHO ORTHO NNP cord-010092-uftc8inx 101 16 - - HYPH cord-010092-uftc8inx 101 17 CT2 CT2 NNP cord-010092-uftc8inx 101 18 : : : cord-010092-uftc8inx 101 19 EudraCT EudraCT NNP cord-010092-uftc8inx 101 20 Number number NN cord-010092-uftc8inx 101 21 : : : cord-010092-uftc8inx 101 22 2012 2012 CD cord-010092-uftc8inx 101 23 - - HYPH cord-010092-uftc8inx 101 24 002010 002010 CD cord-010092-uftc8inx 101 25 - - SYM cord-010092-uftc8inx 101 26 39 39 CD cord-010092-uftc8inx 101 27 ; ; : cord-010092-uftc8inx 101 28 MAXILLO1 maxillo1 XX cord-010092-uftc8inx 101 29 : : : cord-010092-uftc8inx 102 1 EudraCT EudraCT NNP cord-010092-uftc8inx 102 2 Number number NN cord-010092-uftc8inx 102 3 : : : cord-010092-uftc8inx 102 4 2012 2012 CD cord-010092-uftc8inx 102 5 - - HYPH cord-010092-uftc8inx 102 6 003139 003139 CD cord-010092-uftc8inx 102 7 - - SYM cord-010092-uftc8inx 102 8 50 50 CD cord-010092-uftc8inx 102 9 ) ) -RRB- cord-010092-uftc8inx 102 10 . . . cord-010092-uftc8inx 103 1 We -PRON- PRP cord-010092-uftc8inx 103 2 will will MD cord-010092-uftc8inx 103 3 summarize summarize VB cord-010092-uftc8inx 103 4 results result NNS cord-010092-uftc8inx 103 5 of of IN cord-010092-uftc8inx 103 6 completed complete VBN cord-010092-uftc8inx 103 7 clinical clinical JJ cord-010092-uftc8inx 103 8 trials trial NNS cord-010092-uftc8inx 103 9 which which WDT cord-010092-uftc8inx 103 10 confirmed confirm VBD cord-010092-uftc8inx 103 11 feasibility feasibility NN cord-010092-uftc8inx 103 12 and and CC cord-010092-uftc8inx 103 13 safety safety NN cord-010092-uftc8inx 103 14 of of IN cord-010092-uftc8inx 103 15 autologous autologous JJ cord-010092-uftc8inx 103 16 MSC MSC NNP cord-010092-uftc8inx 103 17 /ASC /ASC . cord-010092-uftc8inx 104 1 treatment treatment NN cord-010092-uftc8inx 104 2 and and CC cord-010092-uftc8inx 104 3 provided provide VBD cord-010092-uftc8inx 104 4 evidence evidence NN cord-010092-uftc8inx 104 5 for for IN cord-010092-uftc8inx 104 6 efficacy efficacy NN cord-010092-uftc8inx 104 7 ( ( -LRB- cord-010092-uftc8inx 104 8 Gjerde Gjerde NNP cord-010092-uftc8inx 104 9 et et NNP cord-010092-uftc8inx 104 10 al al NNP cord-010092-uftc8inx 104 11 , , , cord-010092-uftc8inx 105 1 Stem stem JJ cord-010092-uftc8inx 105 2 Cell cell NN cord-010092-uftc8inx 105 3 Res res NN cord-010092-uftc8inx 105 4 . . . cord-010092-uftc8inx 106 1 2018 2018 CD cord-010092-uftc8inx 107 1 Introduction introduction NN cord-010092-uftc8inx 107 2 : : : cord-010092-uftc8inx 108 1 In in IN cord-010092-uftc8inx 108 2 vitro vitro FW cord-010092-uftc8inx 108 3 produced produce VBD cord-010092-uftc8inx 108 4 Megakaryocytes Megakaryocytes NNP cord-010092-uftc8inx 108 5 ( ( -LRB- cord-010092-uftc8inx 108 6 MKs MKs NNP cord-010092-uftc8inx 108 7 ) ) -RRB- cord-010092-uftc8inx 108 8 may may MD cord-010092-uftc8inx 108 9 serve serve VB cord-010092-uftc8inx 108 10 as as IN cord-010092-uftc8inx 108 11 source source NN cord-010092-uftc8inx 108 12 to to TO cord-010092-uftc8inx 108 13 produce produce VB cord-010092-uftc8inx 108 14 platelets platelet NNS cord-010092-uftc8inx 108 15 ( ( -LRB- cord-010092-uftc8inx 108 16 PLTs PLTs NNP cord-010092-uftc8inx 108 17 ) ) -RRB- cord-010092-uftc8inx 108 18 ex ex NN cord-010092-uftc8inx 108 19 vivo vivo NN cord-010092-uftc8inx 108 20 or or CC cord-010092-uftc8inx 108 21 in in IN cord-010092-uftc8inx 108 22 vivo vivo NNP cord-010092-uftc8inx 108 23 . . . cord-010092-uftc8inx 109 1 We -PRON- PRP cord-010092-uftc8inx 109 2 have have VBP cord-010092-uftc8inx 109 3 established establish VBN cord-010092-uftc8inx 109 4 a a DT cord-010092-uftc8inx 109 5 strategy strategy NN cord-010092-uftc8inx 109 6 to to TO cord-010092-uftc8inx 109 7 differentiate differentiate VB cord-010092-uftc8inx 109 8 MKs MKs NNP cord-010092-uftc8inx 109 9 from from IN cord-010092-uftc8inx 109 10 induced induce VBN cord-010092-uftc8inx 109 11 pluripotent pluripotent JJ cord-010092-uftc8inx 109 12 stem stem NN cord-010092-uftc8inx 109 13 cells cell NNS cord-010092-uftc8inx 109 14 ( ( -LRB- cord-010092-uftc8inx 109 15 iPSCs iPSCs NFP cord-010092-uftc8inx 109 16 ) ) -RRB- cord-010092-uftc8inx 109 17 in in IN cord-010092-uftc8inx 109 18 bioreactors bioreactor NNS cord-010092-uftc8inx 109 19 . . . cord-010092-uftc8inx 110 1 This this DT cord-010092-uftc8inx 110 2 study study NN cord-010092-uftc8inx 110 3 aimed aim VBN cord-010092-uftc8inx 110 4 at at IN cord-010092-uftc8inx 110 5 the the DT cord-010092-uftc8inx 110 6 large large JJ cord-010092-uftc8inx 110 7 - - HYPH cord-010092-uftc8inx 110 8 scale scale NN cord-010092-uftc8inx 110 9 production production NN cord-010092-uftc8inx 110 10 of of IN cord-010092-uftc8inx 110 11 MKs mk NNS cord-010092-uftc8inx 110 12 using use VBG cord-010092-uftc8inx 110 13 microcarriers microcarrier NNS cord-010092-uftc8inx 110 14 to to TO cord-010092-uftc8inx 110 15 increase increase VB cord-010092-uftc8inx 110 16 the the DT cord-010092-uftc8inx 110 17 MK MK NNP cord-010092-uftc8inx 110 18 yield yield NN cord-010092-uftc8inx 110 19 and and CC cord-010092-uftc8inx 110 20 to to TO cord-010092-uftc8inx 110 21 characterize characterize VB cord-010092-uftc8inx 110 22 their -PRON- PRP$ cord-010092-uftc8inx 110 23 phenotype phenotype NN cord-010092-uftc8inx 110 24 and and CC cord-010092-uftc8inx 110 25 functionality functionality NN cord-010092-uftc8inx 110 26 after after IN cord-010092-uftc8inx 110 27 irradiation irradiation NN cord-010092-uftc8inx 110 28 as as IN cord-010092-uftc8inx 110 29 a a DT cord-010092-uftc8inx 110 30 method method NN cord-010092-uftc8inx 110 31 to to TO cord-010092-uftc8inx 110 32 decrease decrease VB cord-010092-uftc8inx 110 33 possible possible JJ cord-010092-uftc8inx 110 34 safety safety NN cord-010092-uftc8inx 110 35 concerns concern NNS cord-010092-uftc8inx 110 36 associated associate VBN cord-010092-uftc8inx 110 37 to to IN cord-010092-uftc8inx 110 38 the the DT cord-010092-uftc8inx 110 39 iPSC ipsc JJ cord-010092-uftc8inx 110 40 origin origin NN cord-010092-uftc8inx 110 41 . . . cord-010092-uftc8inx 111 1 Methods method NNS cord-010092-uftc8inx 111 2 : : : cord-010092-uftc8inx 111 3 iPSCs ipscs CD cord-010092-uftc8inx 111 4 were be VBD cord-010092-uftc8inx 111 5 cultured culture VBN cord-010092-uftc8inx 111 6 in in IN cord-010092-uftc8inx 111 7 an an DT cord-010092-uftc8inx 111 8 aggregate aggregate JJ cord-010092-uftc8inx 111 9 form form NN cord-010092-uftc8inx 111 10 in in IN cord-010092-uftc8inx 111 11 presence presence NN cord-010092-uftc8inx 111 12 or or CC cord-010092-uftc8inx 111 13 absence absence NN cord-010092-uftc8inx 111 14 of of IN cord-010092-uftc8inx 111 15 microcarriers microcarrier NNS cord-010092-uftc8inx 111 16 using use VBG cord-010092-uftc8inx 111 17 50 50 CD cord-010092-uftc8inx 111 18 mL mL NNS cord-010092-uftc8inx 111 19 stirred stir VBN cord-010092-uftc8inx 111 20 flasks flask NNS cord-010092-uftc8inx 111 21 . . . cord-010092-uftc8inx 112 1 Cells cell NNS cord-010092-uftc8inx 112 2 were be VBD cord-010092-uftc8inx 112 3 differentiated differentiate VBN cord-010092-uftc8inx 112 4 into into IN cord-010092-uftc8inx 112 5 MKs mk NNS cord-010092-uftc8inx 112 6 using use VBG cord-010092-uftc8inx 112 7 TPO TPO NNP cord-010092-uftc8inx 112 8 , , , cord-010092-uftc8inx 112 9 SCF SCF NNP cord-010092-uftc8inx 112 10 and and CC cord-010092-uftc8inx 112 11 IL-3 IL-3 NNP cord-010092-uftc8inx 113 1 in in IN cord-010092-uftc8inx 113 2 APEL2 apel2 NN cord-010092-uftc8inx 113 3 medium medium NN cord-010092-uftc8inx 113 4 for for IN cord-010092-uftc8inx 113 5 a a DT cord-010092-uftc8inx 113 6 period period NN cord-010092-uftc8inx 113 7 of of IN cord-010092-uftc8inx 113 8 22 22 CD cord-010092-uftc8inx 113 9 days day NNS cord-010092-uftc8inx 113 10 . . . cord-010092-uftc8inx 114 1 Non Non NNS cord-010092-uftc8inx 114 2 - - JJ cord-010092-uftc8inx 114 3 irradiated irradiated JJ cord-010092-uftc8inx 114 4 or or CC cord-010092-uftc8inx 114 5 irradiated irradiate VBN cord-010092-uftc8inx 114 6 iPSC iPSC NNP cord-010092-uftc8inx 114 7 - - HYPH cord-010092-uftc8inx 114 8 derived derive VBN cord-010092-uftc8inx 114 9 MKs mk NNS cord-010092-uftc8inx 114 10 were be VBD cord-010092-uftc8inx 114 11 analysed analyse VBN cord-010092-uftc8inx 114 12 for for IN cord-010092-uftc8inx 114 13 polyploidy polyploidy NN cord-010092-uftc8inx 114 14 , , , cord-010092-uftc8inx 114 15 phenotype phenotype NN cord-010092-uftc8inx 114 16 and and CC cord-010092-uftc8inx 114 17 proPLT proplt VB cord-010092-uftc8inx 114 18 production production NN cord-010092-uftc8inx 114 19 using use VBG cord-010092-uftc8inx 114 20 flow flow NN cord-010092-uftc8inx 114 21 cytometry cytometry NN cord-010092-uftc8inx 114 22 and and CC cord-010092-uftc8inx 114 23 fluorescence fluorescence NN cord-010092-uftc8inx 114 24 microscopy microscopy NNS cord-010092-uftc8inx 114 25 . . . cord-010092-uftc8inx 115 1 Also also RB cord-010092-uftc8inx 115 2 , , , cord-010092-uftc8inx 115 3 PLT PLT NNP cord-010092-uftc8inx 115 4 - - HYPH cord-010092-uftc8inx 115 5 production production NN cord-010092-uftc8inx 115 6 was be VBD cord-010092-uftc8inx 115 7 investigated investigate VBN cord-010092-uftc8inx 115 8 in in IN cord-010092-uftc8inx 115 9 vivo vivo NN cord-010092-uftc8inx 115 10 . . . cord-010092-uftc8inx 116 1 Non Non NNS cord-010092-uftc8inx 116 2 - - JJ cord-010092-uftc8inx 116 3 irradiated irradiated JJ cord-010092-uftc8inx 116 4 or or CC cord-010092-uftc8inx 116 5 irradiated irradiate VBN cord-010092-uftc8inx 116 6 MKs MKs NNP cord-010092-uftc8inx 116 7 were be VBD cord-010092-uftc8inx 116 8 transfused transfuse VBN cord-010092-uftc8inx 116 9 to to IN cord-010092-uftc8inx 116 10 NOD/ NOD/ NNP cord-010092-uftc8inx 116 11 SCID SCID NNP cord-010092-uftc8inx 116 12 / / SYM cord-010092-uftc8inx 116 13 IL-2Rcc-/-mice IL-2Rcc-/-mice NNP cord-010092-uftc8inx 116 14 and and CC cord-010092-uftc8inx 116 15 blood blood NN cord-010092-uftc8inx 116 16 was be VBD cord-010092-uftc8inx 116 17 analyzed analyze VBN cord-010092-uftc8inx 116 18 for for IN cord-010092-uftc8inx 116 19 human human JJ cord-010092-uftc8inx 116 20 PLTs plt NNS cord-010092-uftc8inx 116 21 . . . cord-010092-uftc8inx 117 1 Results result NNS cord-010092-uftc8inx 117 2 : : : cord-010092-uftc8inx 118 1 Differentiation differentiation NN cord-010092-uftc8inx 118 2 of of IN cord-010092-uftc8inx 118 3 MKs MKs NNP cord-010092-uftc8inx 118 4 in in IN cord-010092-uftc8inx 118 5 presence presence NN cord-010092-uftc8inx 118 6 of of IN cord-010092-uftc8inx 118 7 microcarriers microcarrier NNS cord-010092-uftc8inx 118 8 resulted result VBD cord-010092-uftc8inx 118 9 in in IN cord-010092-uftc8inx 118 10 an an DT cord-010092-uftc8inx 118 11 8-fold 8-fold CD cord-010092-uftc8inx 118 12 increase increase NN cord-010092-uftc8inx 118 13 of of IN cord-010092-uftc8inx 118 14 MKs MKs NNP cord-010092-uftc8inx 118 15 per per IN cord-010092-uftc8inx 118 16 iPSC iPSC NNS cord-010092-uftc8inx 118 17 in in IN cord-010092-uftc8inx 118 18 comparison comparison NN cord-010092-uftc8inx 118 19 to to IN cord-010092-uftc8inx 118 20 only only JJ cord-010092-uftc8inx 118 21 aggregates aggregate NNS cord-010092-uftc8inx 118 22 . . . cord-010092-uftc8inx 119 1 This this DT cord-010092-uftc8inx 119 2 resulted result VBD cord-010092-uftc8inx 119 3 in in IN cord-010092-uftc8inx 119 4 mean mean NN cord-010092-uftc8inx 119 5 of of IN cord-010092-uftc8inx 119 6 total total JJ cord-010092-uftc8inx 119 7 MK MK NNP cord-010092-uftc8inx 119 8 harvest harvest NN cord-010092-uftc8inx 119 9 of of IN cord-010092-uftc8inx 119 10 18.7 18.7 CD cord-010092-uftc8inx 119 11 AE AE NNP cord-010092-uftc8inx 119 12 6.8 6.8 CD cord-010092-uftc8inx 119 13 9 9 CD cord-010092-uftc8inx 119 14 10 10 CD cord-010092-uftc8inx 119 15 7 7 CD cord-010092-uftc8inx 119 16 in in IN cord-010092-uftc8inx 119 17 microcarrier microcarrier NN cord-010092-uftc8inx 119 18 - - HYPH cord-010092-uftc8inx 119 19 assisted assist VBN cord-010092-uftc8inx 119 20 bioreactors bioreactor NNS cord-010092-uftc8inx 119 21 in in IN cord-010092-uftc8inx 119 22 comparison comparison NN cord-010092-uftc8inx 119 23 to to IN cord-010092-uftc8inx 119 24 4.9 4.9 CD cord-010092-uftc8inx 119 25 AE AE NNP cord-010092-uftc8inx 119 26 1.3 1.3 CD cord-010092-uftc8inx 119 27 9 9 CD cord-010092-uftc8inx 119 28 10 10 CD cord-010092-uftc8inx 119 29 7 7 CD cord-010092-uftc8inx 119 30 MKs mk NNS cord-010092-uftc8inx 119 31 collected collect VBN cord-010092-uftc8inx 119 32 from from IN cord-010092-uftc8inx 119 33 bioreactors bioreactor NNS cord-010092-uftc8inx 119 34 containing contain VBG cord-010092-uftc8inx 119 35 only only RB cord-010092-uftc8inx 119 36 aggregates aggregate NNS cord-010092-uftc8inx 119 37 . . . cord-010092-uftc8inx 120 1 Interestingly interestingly RB cord-010092-uftc8inx 120 2 , , , cord-010092-uftc8inx 120 3 MKs MKs NNP cord-010092-uftc8inx 120 4 produced produce VBD cord-010092-uftc8inx 120 5 in in IN cord-010092-uftc8inx 120 6 microcarrier microcarrier NN cord-010092-uftc8inx 120 7 - - HYPH cord-010092-uftc8inx 120 8 assisted assist VBN cord-010092-uftc8inx 120 9 bioreactors bioreactor NNS cord-010092-uftc8inx 120 10 showed show VBD cord-010092-uftc8inx 120 11 higher high JJR cord-010092-uftc8inx 120 12 proPLT proplt JJ cord-010092-uftc8inx 120 13 formation formation NN cord-010092-uftc8inx 120 14 capacity capacity NN cord-010092-uftc8inx 120 15 than than IN cord-010092-uftc8inx 120 16 MKs MKs NNP cord-010092-uftc8inx 120 17 derived derive VBN cord-010092-uftc8inx 120 18 from from IN cord-010092-uftc8inx 120 19 only only JJ cord-010092-uftc8inx 120 20 aggregates aggregate NNS cord-010092-uftc8inx 120 21 bioreactors bioreactor NNS cord-010092-uftc8inx 120 22 . . . cord-010092-uftc8inx 121 1 MK MK NNP cord-010092-uftc8inx 121 2 phenotype phenotype NN cord-010092-uftc8inx 121 3 and and CC cord-010092-uftc8inx 121 4 DNA dna NN cord-010092-uftc8inx 121 5 content content NN cord-010092-uftc8inx 121 6 was be VBD cord-010092-uftc8inx 121 7 comparable comparable JJ cord-010092-uftc8inx 121 8 between between IN cord-010092-uftc8inx 121 9 MKs MKs NNP cord-010092-uftc8inx 121 10 derived derive VBN cord-010092-uftc8inx 121 11 from from IN cord-010092-uftc8inx 121 12 both both DT cord-010092-uftc8inx 121 13 types type NNS cord-010092-uftc8inx 121 14 of of IN cord-010092-uftc8inx 121 15 bioreactors bioreactor NNS cord-010092-uftc8inx 121 16 . . . cord-010092-uftc8inx 122 1 Irradiation irradiation NN cord-010092-uftc8inx 122 2 of of IN cord-010092-uftc8inx 122 3 MKs MKs NNP cord-010092-uftc8inx 122 4 did do VBD cord-010092-uftc8inx 122 5 not not RB cord-010092-uftc8inx 122 6 affect affect VB cord-010092-uftc8inx 122 7 their -PRON- PRP$ cord-010092-uftc8inx 122 8 phenotype phenotype NN cord-010092-uftc8inx 122 9 and and CC cord-010092-uftc8inx 122 10 capability capability NN cord-010092-uftc8inx 122 11 to to TO cord-010092-uftc8inx 122 12 form form VB cord-010092-uftc8inx 122 13 proPLTs proPLTs NNP cord-010092-uftc8inx 122 14 or or CC cord-010092-uftc8inx 122 15 PLTs plt NNS cord-010092-uftc8inx 122 16 after after IN cord-010092-uftc8inx 122 17 transfusion transfusion NN cord-010092-uftc8inx 122 18 into into IN cord-010092-uftc8inx 122 19 NOD NOD NNP cord-010092-uftc8inx 122 20 / / SYM cord-010092-uftc8inx 122 21 SCID SCID NNP cord-010092-uftc8inx 122 22 / / SYM cord-010092-uftc8inx 122 23 IL-2Rcc IL-2Rcc NNP cord-010092-uftc8inx 122 24 -/mice -/mice VBP cord-010092-uftc8inx 122 25 . . . cord-010092-uftc8inx 123 1 Conclusion conclusion NN cord-010092-uftc8inx 123 2 : : : cord-010092-uftc8inx 124 1 Microcarriers microcarrier NNS cord-010092-uftc8inx 124 2 showed show VBD cord-010092-uftc8inx 124 3 to to TO cord-010092-uftc8inx 124 4 significantly significantly RB cord-010092-uftc8inx 124 5 increase increase VB cord-010092-uftc8inx 124 6 the the DT cord-010092-uftc8inx 124 7 yield yield NN cord-010092-uftc8inx 124 8 of of IN cord-010092-uftc8inx 124 9 iPSC iPSC NNS cord-010092-uftc8inx 124 10 - - HYPH cord-010092-uftc8inx 124 11 derived derive VBN cord-010092-uftc8inx 124 12 MKs mk NNS cord-010092-uftc8inx 124 13 in in IN cord-010092-uftc8inx 124 14 stirred stir VBN cord-010092-uftc8inx 124 15 bioreactors bioreactor NNS cord-010092-uftc8inx 124 16 to to IN cord-010092-uftc8inx 124 17 clinically clinically RB cord-010092-uftc8inx 124 18 relevant relevant JJ cord-010092-uftc8inx 124 19 numbers number NNS cord-010092-uftc8inx 124 20 . . . cord-010092-uftc8inx 125 1 This this DT cord-010092-uftc8inx 125 2 may may MD cord-010092-uftc8inx 125 3 facilitate facilitate VB cord-010092-uftc8inx 125 4 the the DT cord-010092-uftc8inx 125 5 use use NN cord-010092-uftc8inx 125 6 of of IN cord-010092-uftc8inx 125 7 iPSC iPSC NNS cord-010092-uftc8inx 125 8 - - HYPH cord-010092-uftc8inx 125 9 derived derive VBN cord-010092-uftc8inx 125 10 MK MK NNP cord-010092-uftc8inx 125 11 for for IN cord-010092-uftc8inx 125 12 ex ex FW cord-010092-uftc8inx 125 13 vivo vivo NN cord-010092-uftc8inx 125 14 production production NN cord-010092-uftc8inx 125 15 of of IN cord-010092-uftc8inx 125 16 PLTs plt NNS cord-010092-uftc8inx 125 17 , , , cord-010092-uftc8inx 125 18 direct direct JJ cord-010092-uftc8inx 125 19 transfusion transfusion NN cord-010092-uftc8inx 125 20 or or CC cord-010092-uftc8inx 125 21 for for IN cord-010092-uftc8inx 125 22 innovative innovative JJ cord-010092-uftc8inx 125 23 MK MK NNP cord-010092-uftc8inx 125 24 - - HYPH cord-010092-uftc8inx 125 25 based base VBN cord-010092-uftc8inx 125 26 regenerative regenerative JJ cord-010092-uftc8inx 125 27 therapies therapy NNS cord-010092-uftc8inx 125 28 . . . cord-010092-uftc8inx 126 1 Although although IN cord-010092-uftc8inx 126 2 the the DT cord-010092-uftc8inx 126 3 Rosetta Rosetta NNP cord-010092-uftc8inx 126 4 stone stone NN cord-010092-uftc8inx 126 5 , , , cord-010092-uftc8inx 126 6 found find VBN cord-010092-uftc8inx 126 7 by by IN cord-010092-uftc8inx 126 8 the the DT cord-010092-uftc8inx 126 9 troops troop NNS cord-010092-uftc8inx 126 10 of of IN cord-010092-uftc8inx 126 11 Napoleon Napoleon NNP cord-010092-uftc8inx 126 12 in in IN cord-010092-uftc8inx 126 13 Egypt Egypt NNP cord-010092-uftc8inx 126 14 near near IN cord-010092-uftc8inx 126 15 the the DT cord-010092-uftc8inx 126 16 city city NN cord-010092-uftc8inx 126 17 of of IN cord-010092-uftc8inx 126 18 Rosetta Rosetta NNP cord-010092-uftc8inx 126 19 ( ( -LRB- cord-010092-uftc8inx 126 20 Rashid Rashid NNP cord-010092-uftc8inx 126 21 ) ) -RRB- cord-010092-uftc8inx 126 22 contains contain VBZ cord-010092-uftc8inx 126 23 only only RB cord-010092-uftc8inx 126 24 a a DT cord-010092-uftc8inx 126 25 small small JJ cord-010092-uftc8inx 126 26 amount amount NN cord-010092-uftc8inx 126 27 of of IN cord-010092-uftc8inx 126 28 text text NN cord-010092-uftc8inx 126 29 in in IN cord-010092-uftc8inx 126 30 three three CD cord-010092-uftc8inx 126 31 languages language NNS cord-010092-uftc8inx 126 32 it -PRON- PRP cord-010092-uftc8inx 126 33 was be VBD cord-010092-uftc8inx 126 34 key key JJ cord-010092-uftc8inx 126 35 in in IN cord-010092-uftc8inx 126 36 deciphering decipher VBG cord-010092-uftc8inx 126 37 Hieroglyphs Hieroglyphs NNPS cord-010092-uftc8inx 126 38 . . . cord-010092-uftc8inx 127 1 The the DT cord-010092-uftc8inx 127 2 Rosetta Rosetta NNP cord-010092-uftc8inx 127 3 mission mission NN cord-010092-uftc8inx 127 4 tried try VBD cord-010092-uftc8inx 127 5 to to TO cord-010092-uftc8inx 127 6 achieve achieve VB cord-010092-uftc8inx 127 7 something something NN cord-010092-uftc8inx 127 8 similar similar JJ cord-010092-uftc8inx 127 9 : : : cord-010092-uftc8inx 127 10 by by IN cord-010092-uftc8inx 127 11 looking look VBG cord-010092-uftc8inx 127 12 at at IN cord-010092-uftc8inx 127 13 a a DT cord-010092-uftc8inx 127 14 tiny tiny JJ cord-010092-uftc8inx 127 15 body body NN cord-010092-uftc8inx 127 16 its -PRON- PRP$ cord-010092-uftc8inx 127 17 goal goal NN cord-010092-uftc8inx 127 18 was be VBD cord-010092-uftc8inx 127 19 to to TO cord-010092-uftc8inx 127 20 decipher decipher VB cord-010092-uftc8inx 127 21 the the DT cord-010092-uftc8inx 127 22 origin origin NN cord-010092-uftc8inx 127 23 of of IN cord-010092-uftc8inx 127 24 the the DT cord-010092-uftc8inx 127 25 solar solar JJ cord-010092-uftc8inx 127 26 system system NN cord-010092-uftc8inx 127 27 , , , cord-010092-uftc8inx 127 28 planets planet NNS cord-010092-uftc8inx 127 29 including include VBG cord-010092-uftc8inx 127 30 Earth earth NN cord-010092-uftc8inx 127 31 and and CC cord-010092-uftc8inx 127 32 life life NN cord-010092-uftc8inx 127 33 . . . cord-010092-uftc8inx 128 1 After after IN cord-010092-uftc8inx 128 2 more more JJR cord-010092-uftc8inx 128 3 than than IN cord-010092-uftc8inx 128 4 12 12 CD cord-010092-uftc8inx 128 5 years year NNS cord-010092-uftc8inx 128 6 the the DT cord-010092-uftc8inx 128 7 Rosetta Rosetta NNP cord-010092-uftc8inx 128 8 spacecraft spacecraft NN cord-010092-uftc8inx 128 9 softly softly RB cord-010092-uftc8inx 128 10 crashlanded crashlande VBD cord-010092-uftc8inx 128 11 on on IN cord-010092-uftc8inx 128 12 comet comet JJ cord-010092-uftc8inx 128 13 Churyumov Churyumov NNP cord-010092-uftc8inx 128 14 - - HYPH cord-010092-uftc8inx 128 15 Gerasimenko Gerasimenko NNP cord-010092-uftc8inx 128 16 on on IN cord-010092-uftc8inx 128 17 September September NNP cord-010092-uftc8inx 128 18 30 30 CD cord-010092-uftc8inx 128 19 , , , cord-010092-uftc8inx 128 20 2016 2016 CD cord-010092-uftc8inx 128 21 . . . cord-010092-uftc8inx 129 1 It -PRON- PRP cord-010092-uftc8inx 129 2 has have VBZ cord-010092-uftc8inx 129 3 travelled travel VBN cord-010092-uftc8inx 129 4 billions billion NNS cord-010092-uftc8inx 129 5 of of IN cord-010092-uftc8inx 129 6 kilometers kilometer NNS cord-010092-uftc8inx 129 7 , , , cord-010092-uftc8inx 129 8 just just RB cord-010092-uftc8inx 129 9 to to TO cord-010092-uftc8inx 129 10 study study VB cord-010092-uftc8inx 129 11 a a DT cord-010092-uftc8inx 129 12 small small JJ cord-010092-uftc8inx 129 13 ( ( -LRB- cord-010092-uftc8inx 129 14 4 4 CD cord-010092-uftc8inx 129 15 km km NN cord-010092-uftc8inx 129 16 diameter diameter NN cord-010092-uftc8inx 129 17 ) ) -RRB- cord-010092-uftc8inx 129 18 , , , cord-010092-uftc8inx 129 19 black black JJ cord-010092-uftc8inx 129 20 boulder boulder NN cord-010092-uftc8inx 129 21 named name VBN cord-010092-uftc8inx 129 22 67P/ 67p/ CD cord-010092-uftc8inx 129 23 Churyumov Churyumov NNP cord-010092-uftc8inx 129 24 - - HYPH cord-010092-uftc8inx 129 25 Gerasimenko Gerasimenko NNP cord-010092-uftc8inx 129 26 . . . cord-010092-uftc8inx 130 1 The the DT cord-010092-uftc8inx 130 2 results result NNS cord-010092-uftc8inx 130 3 of of IN cord-010092-uftc8inx 130 4 this this DT cord-010092-uftc8inx 130 5 mission mission NN cord-010092-uftc8inx 130 6 now now RB cord-010092-uftc8inx 130 7 seem seem VBP cord-010092-uftc8inx 130 8 to to TO cord-010092-uftc8inx 130 9 fully fully RB cord-010092-uftc8inx 130 10 justify justify VB cord-010092-uftc8inx 130 11 the the DT cord-010092-uftc8inx 130 12 time time NN cord-010092-uftc8inx 130 13 and and CC cord-010092-uftc8inx 130 14 money money NN cord-010092-uftc8inx 130 15 spent spend VBN cord-010092-uftc8inx 130 16 in in IN cord-010092-uftc8inx 130 17 the the DT cord-010092-uftc8inx 130 18 last last JJ cord-010092-uftc8inx 130 19 decades decade NNS cord-010092-uftc8inx 130 20 on on IN cord-010092-uftc8inx 130 21 this this DT cord-010092-uftc8inx 130 22 endeavor endeavor NN cord-010092-uftc8inx 130 23 . . . cord-010092-uftc8inx 131 1 Where where WRB cord-010092-uftc8inx 131 2 are be VBP cord-010092-uftc8inx 131 3 we -PRON- PRP cord-010092-uftc8inx 131 4 from from IN cord-010092-uftc8inx 131 5 ? ? . cord-010092-uftc8inx 132 1 Where where WRB cord-010092-uftc8inx 132 2 are be VBP cord-010092-uftc8inx 132 3 we -PRON- PRP cord-010092-uftc8inx 132 4 going go VBG cord-010092-uftc8inx 132 5 ? ? . cord-010092-uftc8inx 133 1 Are be VBP cord-010092-uftc8inx 133 2 we -PRON- PRP cord-010092-uftc8inx 133 3 alone alone JJ cord-010092-uftc8inx 133 4 in in IN cord-010092-uftc8inx 133 5 the the DT cord-010092-uftc8inx 133 6 Universe Universe NNP cord-010092-uftc8inx 133 7 ? ? . cord-010092-uftc8inx 134 1 these these DT cord-010092-uftc8inx 134 2 are be VBP cord-010092-uftc8inx 134 3 some some DT cord-010092-uftc8inx 134 4 of of IN cord-010092-uftc8inx 134 5 the the DT cord-010092-uftc8inx 134 6 big big JJ cord-010092-uftc8inx 134 7 questions question NNS cord-010092-uftc8inx 134 8 . . . cord-010092-uftc8inx 135 1 In in IN cord-010092-uftc8inx 135 2 this this DT cord-010092-uftc8inx 135 3 talk talk NN cord-010092-uftc8inx 135 4 I -PRON- PRP cord-010092-uftc8inx 135 5 will will MD cord-010092-uftc8inx 135 6 show show VB cord-010092-uftc8inx 135 7 which which WDT cord-010092-uftc8inx 135 8 answers answer NNS cord-010092-uftc8inx 135 9 we -PRON- PRP cord-010092-uftc8inx 135 10 got get VBD cord-010092-uftc8inx 135 11 from from IN cord-010092-uftc8inx 135 12 Rosetta Rosetta NNP cord-010092-uftc8inx 135 13 and and CC cord-010092-uftc8inx 135 14 comet comet NN cord-010092-uftc8inx 135 15 Chury Chury NNP cord-010092-uftc8inx 135 16 . . . cord-010092-uftc8inx 136 1 We -PRON- PRP cord-010092-uftc8inx 136 2 follow follow VBP cord-010092-uftc8inx 136 3 the the DT cord-010092-uftc8inx 136 4 pathway pathway NN cord-010092-uftc8inx 136 5 of of IN cord-010092-uftc8inx 136 6 the the DT cord-010092-uftc8inx 136 7 material material NN cord-010092-uftc8inx 136 8 which which WDT cord-010092-uftc8inx 136 9 makes make VBZ cord-010092-uftc8inx 136 10 up up RP cord-010092-uftc8inx 136 11 our -PRON- PRP$ cord-010092-uftc8inx 136 12 solar solar JJ cord-010092-uftc8inx 136 13 system system NN cord-010092-uftc8inx 136 14 from from IN cord-010092-uftc8inx 136 15 a a DT cord-010092-uftc8inx 136 16 dark dark JJ cord-010092-uftc8inx 136 17 cloud cloud NN cord-010092-uftc8inx 136 18 to to IN cord-010092-uftc8inx 136 19 the the DT cord-010092-uftc8inx 136 20 solar solar JJ cord-010092-uftc8inx 136 21 nebula nebula NN cord-010092-uftc8inx 136 22 and and CC cord-010092-uftc8inx 136 23 finally finally RB cord-010092-uftc8inx 136 24 to to IN cord-010092-uftc8inx 136 25 planets planet NNS cord-010092-uftc8inx 136 26 and and CC cord-010092-uftc8inx 136 27 life life NN cord-010092-uftc8inx 136 28 . . . cord-010092-uftc8inx 137 1 I -PRON- PRP cord-010092-uftc8inx 137 2 will will MD cord-010092-uftc8inx 137 3 show show VB cord-010092-uftc8inx 137 4 that that IN cord-010092-uftc8inx 137 5 indeed indeed RB cord-010092-uftc8inx 137 6 we -PRON- PRP cord-010092-uftc8inx 137 7 are be VBP cord-010092-uftc8inx 137 8 the the DT cord-010092-uftc8inx 137 9 result result NN cord-010092-uftc8inx 137 10 of of IN cord-010092-uftc8inx 137 11 stardust stardust NN cord-010092-uftc8inx 137 12 and and CC cord-010092-uftc8inx 137 13 that that IN cord-010092-uftc8inx 137 14 what what WP cord-010092-uftc8inx 137 15 happened happen VBD cord-010092-uftc8inx 137 16 here here RB cord-010092-uftc8inx 137 17 may may MD cord-010092-uftc8inx 137 18 happen happen VB cord-010092-uftc8inx 137 19 elsewhere elsewhere RB cord-010092-uftc8inx 137 20 in in IN cord-010092-uftc8inx 137 21 the the DT cord-010092-uftc8inx 137 22 Universe Universe NNP cord-010092-uftc8inx 137 23 . . . cord-010092-uftc8inx 138 1 Cells cell NNS cord-010092-uftc8inx 138 2 , , , cord-010092-uftc8inx 138 3 tissues tissue NNS cord-010092-uftc8inx 138 4 and and CC cord-010092-uftc8inx 138 5 entire entire JJ cord-010092-uftc8inx 138 6 organs organ NNS cord-010092-uftc8inx 138 7 can can MD cord-010092-uftc8inx 138 8 collectively collectively RB cord-010092-uftc8inx 138 9 be be VB cord-010092-uftc8inx 138 10 seen see VBN cord-010092-uftc8inx 138 11 as as IN cord-010092-uftc8inx 138 12 " " `` cord-010092-uftc8inx 138 13 living live VBG cord-010092-uftc8inx 138 14 drugs drug NNS cord-010092-uftc8inx 138 15 " " '' cord-010092-uftc8inx 138 16 . . . cord-010092-uftc8inx 139 1 Genetically genetically DT cord-010092-uftc8inx 139 2 unaltered unaltered JJ cord-010092-uftc8inx 139 3 cells cell NNS cord-010092-uftc8inx 139 4 are be VBP cord-010092-uftc8inx 139 5 routinely routinely RB cord-010092-uftc8inx 139 6 used use VBN cord-010092-uftc8inx 139 7 in in IN cord-010092-uftc8inx 139 8 clinical clinical JJ cord-010092-uftc8inx 139 9 practice practice NN cord-010092-uftc8inx 139 10 to to TO cord-010092-uftc8inx 139 11 treat treat VB cord-010092-uftc8inx 139 12 diseases disease NNS cord-010092-uftc8inx 139 13 as as RB cord-010092-uftc8inx 139 14 diverse diverse JJ cord-010092-uftc8inx 139 15 as as IN cord-010092-uftc8inx 139 16 anemia anemia NN cord-010092-uftc8inx 139 17 , , , cord-010092-uftc8inx 139 18 bleeding bleed VBG cord-010092-uftc8inx 139 19 disorders disorder NNS cord-010092-uftc8inx 139 20 , , , cord-010092-uftc8inx 139 21 leukemia leukemia NN cord-010092-uftc8inx 139 22 and and CC cord-010092-uftc8inx 139 23 organ organ NN cord-010092-uftc8inx 139 24 failure failure NN cord-010092-uftc8inx 139 25 . . . cord-010092-uftc8inx 140 1 Ground ground NN cord-010092-uftc8inx 140 2 - - HYPH cord-010092-uftc8inx 140 3 breaking break VBG cord-010092-uftc8inx 140 4 advances advance NNS cord-010092-uftc8inx 140 5 in in IN cord-010092-uftc8inx 140 6 genetic genetic JJ cord-010092-uftc8inx 140 7 and and CC cord-010092-uftc8inx 140 8 genome genome NN cord-010092-uftc8inx 140 9 engineering engineering NN cord-010092-uftc8inx 140 10 technologies technology NNS cord-010092-uftc8inx 140 11 are be VBP cord-010092-uftc8inx 140 12 propelling propel VBG cord-010092-uftc8inx 140 13 cell cell NN cord-010092-uftc8inx 140 14 therapies therapy NNS cord-010092-uftc8inx 140 15 to to IN cord-010092-uftc8inx 140 16 the the DT cord-010092-uftc8inx 140 17 frontline frontline NN cord-010092-uftc8inx 140 18 of of IN cord-010092-uftc8inx 140 19 Medical medical JJ cord-010092-uftc8inx 140 20 research research NN cord-010092-uftc8inx 140 21 and and CC cord-010092-uftc8inx 140 22 practice practice NN cord-010092-uftc8inx 140 23 . . . cord-010092-uftc8inx 141 1 The the DT cord-010092-uftc8inx 141 2 hematopoietic hematopoietic JJ cord-010092-uftc8inx 141 3 system system NN cord-010092-uftc8inx 141 4 is be VBZ cord-010092-uftc8inx 141 5 particularly particularly RB cord-010092-uftc8inx 141 6 amenable amenable JJ cord-010092-uftc8inx 141 7 to to IN cord-010092-uftc8inx 141 8 genetic genetic JJ cord-010092-uftc8inx 141 9 engineering engineering NN cord-010092-uftc8inx 141 10 because because IN cord-010092-uftc8inx 141 11 specific specific JJ cord-010092-uftc8inx 141 12 cell cell NN cord-010092-uftc8inx 141 13 types type NNS cord-010092-uftc8inx 141 14 can can MD cord-010092-uftc8inx 141 15 be be VB cord-010092-uftc8inx 141 16 purified purify VBN cord-010092-uftc8inx 141 17 based base VBN cord-010092-uftc8inx 141 18 on on IN cord-010092-uftc8inx 141 19 the the DT cord-010092-uftc8inx 141 20 expression expression NN cord-010092-uftc8inx 141 21 of of IN cord-010092-uftc8inx 141 22 specific specific JJ cord-010092-uftc8inx 141 23 surface surface NN cord-010092-uftc8inx 141 24 proteins protein NNS cord-010092-uftc8inx 141 25 and and CC cord-010092-uftc8inx 141 26 the the DT cord-010092-uftc8inx 141 27 ability ability NN cord-010092-uftc8inx 141 28 to to TO cord-010092-uftc8inx 141 29 culture culture NN cord-010092-uftc8inx 141 30 and and CC cord-010092-uftc8inx 141 31 expand expand VB cord-010092-uftc8inx 141 32 cells cell NNS cord-010092-uftc8inx 141 33 ex ex FW cord-010092-uftc8inx 141 34 vivo vivo NN cord-010092-uftc8inx 141 35 . . . cord-010092-uftc8inx 142 1 The the DT cord-010092-uftc8inx 142 2 recent recent JJ cord-010092-uftc8inx 142 3 unprecedented unprecedented JJ cord-010092-uftc8inx 142 4 clinical clinical JJ cord-010092-uftc8inx 142 5 success success NN cord-010092-uftc8inx 142 6 of of IN cord-010092-uftc8inx 142 7 killer killer NN cord-010092-uftc8inx 142 8 T t NN cord-010092-uftc8inx 142 9 cells cell NNS cord-010092-uftc8inx 142 10 reprogrammed reprogramme VBN cord-010092-uftc8inx 142 11 by by IN cord-010092-uftc8inx 142 12 chimeric chimeric JJ cord-010092-uftc8inx 142 13 antigen antigen NN cord-010092-uftc8inx 142 14 receptors receptor NNS cord-010092-uftc8inx 142 15 ( ( -LRB- cord-010092-uftc8inx 142 16 CARs car NNS cord-010092-uftc8inx 142 17 ) ) -RRB- cord-010092-uftc8inx 142 18 to to TO cord-010092-uftc8inx 142 19 attack attack VB cord-010092-uftc8inx 142 20 CD19 CD19 NNP cord-010092-uftc8inx 142 21 expressing express VBG cord-010092-uftc8inx 142 22 tumor tumor NN cord-010092-uftc8inx 142 23 cells cell NNS cord-010092-uftc8inx 142 24 demonstrates demonstrate VBZ cord-010092-uftc8inx 142 25 the the DT cord-010092-uftc8inx 142 26 power power NN cord-010092-uftc8inx 142 27 of of IN cord-010092-uftc8inx 142 28 immunotherapy immunotherapy NN cord-010092-uftc8inx 142 29 with with IN cord-010092-uftc8inx 142 30 genetically genetically RB cord-010092-uftc8inx 142 31 engineered engineer VBN cord-010092-uftc8inx 142 32 immune immune JJ cord-010092-uftc8inx 142 33 cells cell NNS cord-010092-uftc8inx 142 34 . . . cord-010092-uftc8inx 143 1 However however RB cord-010092-uftc8inx 143 2 , , , cord-010092-uftc8inx 143 3 given give VBN cord-010092-uftc8inx 143 4 the the DT cord-010092-uftc8inx 143 5 rapid rapid JJ cord-010092-uftc8inx 143 6 development development NN cord-010092-uftc8inx 143 7 of of IN cord-010092-uftc8inx 143 8 novel novel JJ cord-010092-uftc8inx 143 9 genome genome NN cord-010092-uftc8inx 143 10 engineering engineering NN cord-010092-uftc8inx 143 11 and and CC cord-010092-uftc8inx 143 12 synthetic synthetic JJ cord-010092-uftc8inx 143 13 biology biology NN cord-010092-uftc8inx 143 14 tools tool NNS cord-010092-uftc8inx 143 15 we -PRON- PRP cord-010092-uftc8inx 143 16 are be VBP cord-010092-uftc8inx 143 17 likely likely JJ cord-010092-uftc8inx 143 18 only only RB cord-010092-uftc8inx 143 19 at at IN cord-010092-uftc8inx 143 20 the the DT cord-010092-uftc8inx 143 21 beginning beginning NN cord-010092-uftc8inx 143 22 of of IN cord-010092-uftc8inx 143 23 a a DT cord-010092-uftc8inx 143 24 new new JJ cord-010092-uftc8inx 143 25 era era NN cord-010092-uftc8inx 143 26 of of IN cord-010092-uftc8inx 143 27 engineered engineer VBN cord-010092-uftc8inx 143 28 cellular cellular JJ cord-010092-uftc8inx 143 29 therapies therapy NNS cord-010092-uftc8inx 143 30 . . . cord-010092-uftc8inx 144 1 I -PRON- PRP cord-010092-uftc8inx 144 2 will will MD cord-010092-uftc8inx 144 3 present present VB cord-010092-uftc8inx 144 4 recent recent JJ cord-010092-uftc8inx 144 5 progress progress NN cord-010092-uftc8inx 144 6 in in IN cord-010092-uftc8inx 144 7 immune immune JJ cord-010092-uftc8inx 144 8 cell cell NN cord-010092-uftc8inx 144 9 reprogramming reprogramming NN cord-010092-uftc8inx 144 10 , , , cord-010092-uftc8inx 144 11 gene gene NN cord-010092-uftc8inx 144 12 correction correction NN cord-010092-uftc8inx 144 13 , , , cord-010092-uftc8inx 144 14 safety safety NN cord-010092-uftc8inx 144 15 aspects aspect NNS cord-010092-uftc8inx 144 16 and and CC cord-010092-uftc8inx 144 17 remaining remain VBG cord-010092-uftc8inx 144 18 challenges challenge NNS cord-010092-uftc8inx 144 19 such such JJ cord-010092-uftc8inx 144 20 as as IN cord-010092-uftc8inx 144 21 manufacturing manufacturing NN cord-010092-uftc8inx 144 22 . . . cord-010092-uftc8inx 145 1 1D-04 1d-04 CD cord-010092-uftc8inx 145 2 - - SYM cord-010092-uftc8inx 145 3 03 03 CD cord-010092-uftc8inx 145 4 Cell cell NN cord-010092-uftc8inx 145 5 free free JJ cord-010092-uftc8inx 145 6 nucleic nucleic JJ cord-010092-uftc8inx 145 7 acids acid NNS cord-010092-uftc8inx 145 8 ( ( -LRB- cord-010092-uftc8inx 145 9 CFNA CFNA NNP cord-010092-uftc8inx 145 10 ) ) -RRB- cord-010092-uftc8inx 145 11 circulate circulate VB cord-010092-uftc8inx 145 12 in in IN cord-010092-uftc8inx 145 13 the the DT cord-010092-uftc8inx 145 14 plasma plasma NN cord-010092-uftc8inx 145 15 of of IN cord-010092-uftc8inx 145 16 all all DT cord-010092-uftc8inx 145 17 individuals individual NNS cord-010092-uftc8inx 145 18 and and CC cord-010092-uftc8inx 145 19 are be VBP cord-010092-uftc8inx 145 20 thought think VBN cord-010092-uftc8inx 145 21 to to TO cord-010092-uftc8inx 145 22 be be VB cord-010092-uftc8inx 145 23 released release VBN cord-010092-uftc8inx 145 24 by by IN cord-010092-uftc8inx 145 25 host host NN cord-010092-uftc8inx 145 26 and and CC cord-010092-uftc8inx 145 27 foreign foreign JJ cord-010092-uftc8inx 145 28 cells cell NNS cord-010092-uftc8inx 145 29 into into IN cord-010092-uftc8inx 145 30 the the DT cord-010092-uftc8inx 145 31 circulation circulation NN cord-010092-uftc8inx 145 32 . . . cord-010092-uftc8inx 146 1 After after IN cord-010092-uftc8inx 146 2 fractionation fractionation NN cord-010092-uftc8inx 146 3 by by IN cord-010092-uftc8inx 146 4 centrifugation centrifugation NN cord-010092-uftc8inx 146 5 , , , cord-010092-uftc8inx 146 6 CFNAs cfna NNS cord-010092-uftc8inx 146 7 can can MD cord-010092-uftc8inx 146 8 be be VB cord-010092-uftc8inx 146 9 extracted extract VBN cord-010092-uftc8inx 146 10 from from IN cord-010092-uftc8inx 146 11 the the DT cord-010092-uftc8inx 146 12 supernatant supernatant NN cord-010092-uftc8inx 146 13 of of IN cord-010092-uftc8inx 146 14 whole whole JJ cord-010092-uftc8inx 146 15 blood blood NN cord-010092-uftc8inx 146 16 samples sample NNS cord-010092-uftc8inx 146 17 or or CC cord-010092-uftc8inx 146 18 manufactured manufacture VBN cord-010092-uftc8inx 146 19 blood blood NN cord-010092-uftc8inx 146 20 products product NNS cord-010092-uftc8inx 146 21 . . . cord-010092-uftc8inx 147 1 These these DT cord-010092-uftc8inx 147 2 DNA DNA NNP cord-010092-uftc8inx 147 3 or or CC cord-010092-uftc8inx 147 4 RNA RNA NNP cord-010092-uftc8inx 147 5 sequences sequence NNS cord-010092-uftc8inx 147 6 can can MD cord-010092-uftc8inx 147 7 be be VB cord-010092-uftc8inx 147 8 of of IN cord-010092-uftc8inx 147 9 human human JJ cord-010092-uftc8inx 147 10 , , , cord-010092-uftc8inx 147 11 bacterial bacterial JJ cord-010092-uftc8inx 147 12 , , , cord-010092-uftc8inx 147 13 viral viral JJ cord-010092-uftc8inx 147 14 or or CC cord-010092-uftc8inx 147 15 fungal fungal JJ cord-010092-uftc8inx 147 16 origin origin NN cord-010092-uftc8inx 147 17 . . . cord-010092-uftc8inx 148 1 Most Most JJS cord-010092-uftc8inx 148 2 of of IN cord-010092-uftc8inx 148 3 them -PRON- PRP cord-010092-uftc8inx 148 4 are be VBP cord-010092-uftc8inx 148 5 human human JJ cord-010092-uftc8inx 148 6 double double JJ cord-010092-uftc8inx 148 7 stranded strand VBN cord-010092-uftc8inx 148 8 DNAs dna NNS cord-010092-uftc8inx 148 9 . . . cord-010092-uftc8inx 149 1 Research research NN cord-010092-uftc8inx 149 2 on on IN cord-010092-uftc8inx 149 3 CFNAs CFNAs NNPS cord-010092-uftc8inx 149 4 is be VBZ cord-010092-uftc8inx 149 5 increasing increase VBG cord-010092-uftc8inx 149 6 , , , cord-010092-uftc8inx 149 7 thanks thank NNS cord-010092-uftc8inx 149 8 to to IN cord-010092-uftc8inx 149 9 technological technological JJ cord-010092-uftc8inx 149 10 advancements advancement NNS cord-010092-uftc8inx 149 11 in in IN cord-010092-uftc8inx 149 12 molecular molecular JJ cord-010092-uftc8inx 149 13 biology biology NN cord-010092-uftc8inx 149 14 . . . cord-010092-uftc8inx 150 1 Some some DT cord-010092-uftc8inx 150 2 of of IN cord-010092-uftc8inx 150 3 their -PRON- PRP$ cord-010092-uftc8inx 150 4 results result NNS cord-010092-uftc8inx 150 5 are be VBP cord-010092-uftc8inx 150 6 already already RB cord-010092-uftc8inx 150 7 implemented implement VBN cord-010092-uftc8inx 150 8 in in IN cord-010092-uftc8inx 150 9 clinical clinical JJ cord-010092-uftc8inx 150 10 practice practice NN cord-010092-uftc8inx 150 11 in in IN cord-010092-uftc8inx 150 12 the the DT cord-010092-uftc8inx 150 13 areas area NNS cord-010092-uftc8inx 150 14 of of IN cord-010092-uftc8inx 150 15 prenatal prenatal JJ cord-010092-uftc8inx 150 16 diagnosis diagnosis NN cord-010092-uftc8inx 150 17 , , , cord-010092-uftc8inx 150 18 oncology oncology NN cord-010092-uftc8inx 150 19 and and CC cord-010092-uftc8inx 150 20 infectious infectious JJ cord-010092-uftc8inx 150 21 diseases disease NNS cord-010092-uftc8inx 150 22 . . . cord-010092-uftc8inx 151 1 The the DT cord-010092-uftc8inx 151 2 latter latter JJ cord-010092-uftc8inx 151 3 investigation investigation NN cord-010092-uftc8inx 151 4 focuses focus VBZ cord-010092-uftc8inx 151 5 on on IN cord-010092-uftc8inx 151 6 the the DT cord-010092-uftc8inx 151 7 exploration exploration NN cord-010092-uftc8inx 151 8 of of IN cord-010092-uftc8inx 151 9 non non JJ cord-010092-uftc8inx 151 10 - - JJ cord-010092-uftc8inx 151 11 human human JJ cord-010092-uftc8inx 151 12 CFNAs cfna NNS cord-010092-uftc8inx 151 13 , , , cord-010092-uftc8inx 151 14 the the DT cord-010092-uftc8inx 151 15 field field NN cord-010092-uftc8inx 151 16 of of IN cord-010092-uftc8inx 151 17 metagenomics metagenomic NNS cord-010092-uftc8inx 151 18 . . . cord-010092-uftc8inx 152 1 High high JJ cord-010092-uftc8inx 152 2 throughput throughput NN cord-010092-uftc8inx 152 3 sequencing sequencing NN cord-010092-uftc8inx 152 4 associated associate VBN cord-010092-uftc8inx 152 5 with with IN cord-010092-uftc8inx 152 6 bioinformatics bioinformatic NNS cord-010092-uftc8inx 152 7 , , , cord-010092-uftc8inx 152 8 the the DT cord-010092-uftc8inx 152 9 so so RB cord-010092-uftc8inx 152 10 - - HYPH cord-010092-uftc8inx 152 11 called call VBN cord-010092-uftc8inx 152 12 new new JJ cord-010092-uftc8inx 152 13 generation generation NN cord-010092-uftc8inx 152 14 sequencing sequencing NN cord-010092-uftc8inx 152 15 ( ( -LRB- cord-010092-uftc8inx 152 16 NGS NGS NNP cord-010092-uftc8inx 152 17 ) ) -RRB- cord-010092-uftc8inx 152 18 , , , cord-010092-uftc8inx 152 19 has have VBZ cord-010092-uftc8inx 152 20 sped speed VBN cord-010092-uftc8inx 152 21 up up RP cord-010092-uftc8inx 152 22 the the DT cord-010092-uftc8inx 152 23 investigations investigation NNS cord-010092-uftc8inx 152 24 of of IN cord-010092-uftc8inx 152 25 non non JJ cord-010092-uftc8inx 152 26 - - JJ cord-010092-uftc8inx 152 27 human human JJ cord-010092-uftc8inx 152 28 CFNAs cfna NNS cord-010092-uftc8inx 152 29 . . . cord-010092-uftc8inx 153 1 This this DT cord-010092-uftc8inx 153 2 tool tool NN cord-010092-uftc8inx 153 3 provides provide VBZ cord-010092-uftc8inx 153 4 the the DT cord-010092-uftc8inx 153 5 opportunity opportunity NN cord-010092-uftc8inx 153 6 to to TO cord-010092-uftc8inx 153 7 classify classify VB cord-010092-uftc8inx 153 8 CFNAs cfna NNS cord-010092-uftc8inx 153 9 into into IN cord-010092-uftc8inx 153 10 a a DT cord-010092-uftc8inx 153 11 human human JJ cord-010092-uftc8inx 153 12 or or CC cord-010092-uftc8inx 153 13 non non JJ cord-010092-uftc8inx 153 14 - - JJ cord-010092-uftc8inx 153 15 human human JJ cord-010092-uftc8inx 153 16 category category NN cord-010092-uftc8inx 153 17 , , , cord-010092-uftc8inx 153 18 and and CC cord-010092-uftc8inx 153 19 then then RB cord-010092-uftc8inx 153 20 to to TO cord-010092-uftc8inx 153 21 identify identify VB cord-010092-uftc8inx 153 22 them -PRON- PRP cord-010092-uftc8inx 153 23 . . . cord-010092-uftc8inx 154 1 It -PRON- PRP cord-010092-uftc8inx 154 2 is be VBZ cord-010092-uftc8inx 154 3 thus thus RB cord-010092-uftc8inx 154 4 possible possible JJ cord-010092-uftc8inx 154 5 to to TO cord-010092-uftc8inx 154 6 explore explore VB cord-010092-uftc8inx 154 7 simultaneously simultaneously RB cord-010092-uftc8inx 154 8 the the DT cord-010092-uftc8inx 154 9 whole whole JJ cord-010092-uftc8inx 154 10 landscape landscape NN cord-010092-uftc8inx 154 11 of of IN cord-010092-uftc8inx 154 12 bacterial bacterial JJ cord-010092-uftc8inx 154 13 , , , cord-010092-uftc8inx 154 14 viral viral JJ cord-010092-uftc8inx 154 15 and and CC cord-010092-uftc8inx 154 16 fungal fungal JJ cord-010092-uftc8inx 154 17 populations population NNS cord-010092-uftc8inx 154 18 . . . cord-010092-uftc8inx 155 1 Presently presently RB cord-010092-uftc8inx 155 2 , , , cord-010092-uftc8inx 155 3 NGS NGS NNP cord-010092-uftc8inx 155 4 of of IN cord-010092-uftc8inx 155 5 human human JJ cord-010092-uftc8inx 155 6 blood blood NN cord-010092-uftc8inx 155 7 has have VBZ cord-010092-uftc8inx 155 8 already already RB cord-010092-uftc8inx 155 9 proven prove VBN cord-010092-uftc8inx 155 10 its -PRON- PRP$ cord-010092-uftc8inx 155 11 feasibility feasibility NN cord-010092-uftc8inx 155 12 and and CC cord-010092-uftc8inx 155 13 its -PRON- PRP$ cord-010092-uftc8inx 155 14 value value NN cord-010092-uftc8inx 155 15 in in IN cord-010092-uftc8inx 155 16 identifying identify VBG cord-010092-uftc8inx 155 17 emerging emerge VBG cord-010092-uftc8inx 155 18 viruses virus NNS cord-010092-uftc8inx 155 19 or or CC cord-010092-uftc8inx 155 20 investigating investigate VBG cord-010092-uftc8inx 155 21 clinical clinical JJ cord-010092-uftc8inx 155 22 cases case NNS cord-010092-uftc8inx 155 23 of of IN cord-010092-uftc8inx 155 24 fever fever NN cord-010092-uftc8inx 155 25 of of IN cord-010092-uftc8inx 155 26 unknown unknown JJ cord-010092-uftc8inx 155 27 etiology etiology NN cord-010092-uftc8inx 155 28 . . . cord-010092-uftc8inx 156 1 NGS NGS NNP cord-010092-uftc8inx 156 2 of of IN cord-010092-uftc8inx 156 3 CFNAs CFNAs NNPS cord-010092-uftc8inx 156 4 is be VBZ cord-010092-uftc8inx 156 5 also also RB cord-010092-uftc8inx 156 6 particularly particularly RB cord-010092-uftc8inx 156 7 effective effective JJ cord-010092-uftc8inx 156 8 in in IN cord-010092-uftc8inx 156 9 analyzing analyze VBG cord-010092-uftc8inx 156 10 the the DT cord-010092-uftc8inx 156 11 different different JJ cord-010092-uftc8inx 156 12 genotypes genotype NNS cord-010092-uftc8inx 156 13 of of IN cord-010092-uftc8inx 156 14 a a DT cord-010092-uftc8inx 156 15 virus virus NN cord-010092-uftc8inx 156 16 in in IN cord-010092-uftc8inx 156 17 case case NN cord-010092-uftc8inx 156 18 of of IN cord-010092-uftc8inx 156 19 a a DT cord-010092-uftc8inx 156 20 co co NN cord-010092-uftc8inx 156 21 - - NN cord-010092-uftc8inx 156 22 infection infection NN cord-010092-uftc8inx 156 23 ( ( -LRB- cord-010092-uftc8inx 156 24 e.g. e.g. RB cord-010092-uftc8inx 156 25 Hepatitis Hepatitis NNP cord-010092-uftc8inx 156 26 C C NNP cord-010092-uftc8inx 156 27 virus virus NN cord-010092-uftc8inx 156 28 ) ) -RRB- cord-010092-uftc8inx 156 29 . . . cord-010092-uftc8inx 157 1 Studying study VBG cord-010092-uftc8inx 157 2 CFNAs cfna NNS cord-010092-uftc8inx 157 3 with with IN cord-010092-uftc8inx 157 4 the the DT cord-010092-uftc8inx 157 5 new new JJ cord-010092-uftc8inx 157 6 molecular molecular JJ cord-010092-uftc8inx 157 7 technologies technology NNS cord-010092-uftc8inx 157 8 is be VBZ cord-010092-uftc8inx 157 9 therefore therefore RB cord-010092-uftc8inx 157 10 of of IN cord-010092-uftc8inx 157 11 great great JJ cord-010092-uftc8inx 157 12 importance importance NN cord-010092-uftc8inx 157 13 in in IN cord-010092-uftc8inx 157 14 transfusion transfusion NN cord-010092-uftc8inx 157 15 medicine medicine NN cord-010092-uftc8inx 157 16 , , , cord-010092-uftc8inx 157 17 especially especially RB cord-010092-uftc8inx 157 18 regarding regard VBG cord-010092-uftc8inx 157 19 security security NN cord-010092-uftc8inx 157 20 and and CC cord-010092-uftc8inx 157 21 clinical clinical JJ cord-010092-uftc8inx 157 22 transfusion transfusion NN cord-010092-uftc8inx 157 23 reactions reaction NNS cord-010092-uftc8inx 157 24 . . . cord-010092-uftc8inx 158 1 First first RB cord-010092-uftc8inx 158 2 , , , cord-010092-uftc8inx 158 3 transfusion transfusion NN cord-010092-uftc8inx 158 4 transmitted transmit VBN cord-010092-uftc8inx 158 5 infections infection NNS cord-010092-uftc8inx 158 6 are be VBP cord-010092-uftc8inx 158 7 the the DT cord-010092-uftc8inx 158 8 most most RBS cord-010092-uftc8inx 158 9 feared fear VBN cord-010092-uftc8inx 158 10 adverse adverse JJ cord-010092-uftc8inx 158 11 complications complication NNS cord-010092-uftc8inx 158 12 . . . cord-010092-uftc8inx 159 1 Second second JJ cord-010092-uftc8inx 159 2 , , , cord-010092-uftc8inx 159 3 febrile febrile JJ cord-010092-uftc8inx 159 4 non non JJ cord-010092-uftc8inx 159 5 - - JJ cord-010092-uftc8inx 159 6 hemolytic hemolytic JJ cord-010092-uftc8inx 159 7 transfusion transfusion NN cord-010092-uftc8inx 159 8 reactions reaction NNS cord-010092-uftc8inx 159 9 are be VBP cord-010092-uftc8inx 159 10 also also RB cord-010092-uftc8inx 159 11 the the DT cord-010092-uftc8inx 159 12 most most RBS cord-010092-uftc8inx 159 13 frequently frequently RB cord-010092-uftc8inx 159 14 reported report VBD cord-010092-uftc8inx 159 15 adverse adverse JJ cord-010092-uftc8inx 159 16 events event NNS cord-010092-uftc8inx 159 17 in in IN cord-010092-uftc8inx 159 18 hemovigilance hemovigilance NN cord-010092-uftc8inx 159 19 systems system NNS cord-010092-uftc8inx 159 20 and and CC cord-010092-uftc8inx 159 21 their -PRON- PRP$ cord-010092-uftc8inx 159 22 physiological physiological JJ cord-010092-uftc8inx 159 23 mechanism mechanism NN cord-010092-uftc8inx 159 24 -if -if ADD cord-010092-uftc8inx 160 1 only only RB cord-010092-uftc8inx 160 2 one one CD cord-010092-uftc8inx 160 3 - - : cord-010092-uftc8inx 160 4 remains remain VBZ cord-010092-uftc8inx 160 5 not not RB cord-010092-uftc8inx 160 6 clearly clearly RB cord-010092-uftc8inx 160 7 elucidated elucidate VBN cord-010092-uftc8inx 160 8 . . . cord-010092-uftc8inx 161 1 Investigating investigate VBG cord-010092-uftc8inx 161 2 CFNAs cfna NNS cord-010092-uftc8inx 161 3 could could MD cord-010092-uftc8inx 161 4 thus thus RB cord-010092-uftc8inx 161 5 improve improve VB cord-010092-uftc8inx 161 6 our -PRON- PRP$ cord-010092-uftc8inx 161 7 understanding understanding NN cord-010092-uftc8inx 161 8 and and CC cord-010092-uftc8inx 161 9 strategy strategy NN cord-010092-uftc8inx 161 10 aiming aim VBG cord-010092-uftc8inx 161 11 at at IN cord-010092-uftc8inx 161 12 reducing reduce VBG cord-010092-uftc8inx 161 13 those those DT cord-010092-uftc8inx 161 14 two two CD cord-010092-uftc8inx 161 15 clinical clinical JJ cord-010092-uftc8inx 161 16 adverse adverse JJ cord-010092-uftc8inx 161 17 events event NNS cord-010092-uftc8inx 161 18 . . . cord-010092-uftc8inx 162 1 Surveying survey VBG cord-010092-uftc8inx 162 2 comprehensively comprehensively RB cord-010092-uftc8inx 162 3 the the DT cord-010092-uftc8inx 162 4 composition composition NN cord-010092-uftc8inx 162 5 of of IN cord-010092-uftc8inx 162 6 circulating circulate VBG cord-010092-uftc8inx 162 7 infectious infectious JJ cord-010092-uftc8inx 162 8 agents agent NNS cord-010092-uftc8inx 162 9 in in IN cord-010092-uftc8inx 162 10 a a DT cord-010092-uftc8inx 162 11 blood blood NN cord-010092-uftc8inx 162 12 product product NN cord-010092-uftc8inx 162 13 by by IN cord-010092-uftc8inx 162 14 NGS NGS NNP cord-010092-uftc8inx 162 15 technology technology NN cord-010092-uftc8inx 162 16 could could MD cord-010092-uftc8inx 162 17 be be VB cord-010092-uftc8inx 162 18 very very RB cord-010092-uftc8inx 162 19 interesting interesting JJ cord-010092-uftc8inx 162 20 for for IN cord-010092-uftc8inx 162 21 investigating investigate VBG cord-010092-uftc8inx 162 22 a a DT cord-010092-uftc8inx 162 23 severe severe JJ cord-010092-uftc8inx 162 24 febrile febrile JJ cord-010092-uftc8inx 162 25 transfusion transfusion NN cord-010092-uftc8inx 162 26 reaction reaction NN cord-010092-uftc8inx 162 27 . . . cord-010092-uftc8inx 163 1 Moreover moreover RB cord-010092-uftc8inx 163 2 , , , cord-010092-uftc8inx 163 3 when when WRB cord-010092-uftc8inx 163 4 the the DT cord-010092-uftc8inx 163 5 costs cost NNS cord-010092-uftc8inx 163 6 of of IN cord-010092-uftc8inx 163 7 analysis analysis NN cord-010092-uftc8inx 163 8 will will MD cord-010092-uftc8inx 163 9 be be VB cord-010092-uftc8inx 163 10 reduced reduce VBN cord-010092-uftc8inx 163 11 , , , cord-010092-uftc8inx 163 12 it -PRON- PRP cord-010092-uftc8inx 163 13 might may MD cord-010092-uftc8inx 163 14 be be VB cord-010092-uftc8inx 163 15 possible possible JJ cord-010092-uftc8inx 163 16 to to TO cord-010092-uftc8inx 163 17 screen screen VB cord-010092-uftc8inx 163 18 prospectively prospectively RB cord-010092-uftc8inx 163 19 and and CC cord-010092-uftc8inx 163 20 regularly regularly RB cord-010092-uftc8inx 163 21 the the DT cord-010092-uftc8inx 163 22 whole whole JJ cord-010092-uftc8inx 163 23 metagenomics metagenomic NNS cord-010092-uftc8inx 163 24 of of IN cord-010092-uftc8inx 163 25 asymptomatic asymptomatic JJ cord-010092-uftc8inx 163 26 blood blood NN cord-010092-uftc8inx 163 27 donors donor NNS cord-010092-uftc8inx 163 28 , , , cord-010092-uftc8inx 163 29 in in IN cord-010092-uftc8inx 163 30 addition addition NN cord-010092-uftc8inx 163 31 to to IN cord-010092-uftc8inx 163 32 the the DT cord-010092-uftc8inx 163 33 classical classical JJ cord-010092-uftc8inx 163 34 epidemiological epidemiological JJ cord-010092-uftc8inx 163 35 surveillance surveillance NN cord-010092-uftc8inx 163 36 . . . cord-010092-uftc8inx 164 1 For for IN cord-010092-uftc8inx 164 2 instance instance NN cord-010092-uftc8inx 164 3 , , , cord-010092-uftc8inx 164 4 in in IN cord-010092-uftc8inx 164 5 a a DT cord-010092-uftc8inx 164 6 study study NN cord-010092-uftc8inx 164 7 testing test VBG cord-010092-uftc8inx 164 8 a a DT cord-010092-uftc8inx 164 9 NGS NGS NNP cord-010092-uftc8inx 164 10 method method NN cord-010092-uftc8inx 164 11 on on IN cord-010092-uftc8inx 164 12 manufactured manufacture VBN cord-010092-uftc8inx 164 13 fresh fresh JJ cord-010092-uftc8inx 164 14 frozen frozen JJ cord-010092-uftc8inx 164 15 plasmas plasma NNS cord-010092-uftc8inx 164 16 , , , cord-010092-uftc8inx 164 17 an an DT cord-010092-uftc8inx 164 18 astrovirus astrovirus NN cord-010092-uftc8inx 164 19 ( ( -LRB- cord-010092-uftc8inx 164 20 MLB2 MLB2 NNP cord-010092-uftc8inx 164 21 ) ) -RRB- cord-010092-uftc8inx 164 22 has have VBZ cord-010092-uftc8inx 164 23 been be VBN cord-010092-uftc8inx 164 24 identified identify VBN cord-010092-uftc8inx 164 25 . . . cord-010092-uftc8inx 165 1 Finally finally RB cord-010092-uftc8inx 165 2 , , , cord-010092-uftc8inx 165 3 it -PRON- PRP cord-010092-uftc8inx 165 4 is be VBZ cord-010092-uftc8inx 165 5 the the DT cord-010092-uftc8inx 165 6 responsibility responsibility NN cord-010092-uftc8inx 165 7 of of IN cord-010092-uftc8inx 165 8 transfusion transfusion NN cord-010092-uftc8inx 165 9 physicians physician NNS cord-010092-uftc8inx 165 10 implicated implicate VBN cord-010092-uftc8inx 165 11 in in IN cord-010092-uftc8inx 165 12 the the DT cord-010092-uftc8inx 165 13 manufacturing manufacturing NN cord-010092-uftc8inx 165 14 of of IN cord-010092-uftc8inx 165 15 blood blood NN cord-010092-uftc8inx 165 16 products product NNS cord-010092-uftc8inx 165 17 to to TO cord-010092-uftc8inx 165 18 ensure ensure VB cord-010092-uftc8inx 165 19 that that IN cord-010092-uftc8inx 165 20 CFNAs cfna NNS cord-010092-uftc8inx 165 21 within within IN cord-010092-uftc8inx 165 22 a a DT cord-010092-uftc8inx 165 23 blood blood NN cord-010092-uftc8inx 165 24 product product NN cord-010092-uftc8inx 165 25 do do VBP cord-010092-uftc8inx 165 26 not not RB cord-010092-uftc8inx 165 27 have have VB cord-010092-uftc8inx 165 28 a a DT cord-010092-uftc8inx 165 29 clinical clinical JJ cord-010092-uftc8inx 165 30 impact impact NN cord-010092-uftc8inx 165 31 on on IN cord-010092-uftc8inx 165 32 the the DT cord-010092-uftc8inx 165 33 innate innate JJ cord-010092-uftc8inx 165 34 immunity immunity NN cord-010092-uftc8inx 165 35 of of IN cord-010092-uftc8inx 165 36 the the DT cord-010092-uftc8inx 165 37 recipients recipient NNS cord-010092-uftc8inx 165 38 . . . cord-010092-uftc8inx 166 1 According accord VBG cord-010092-uftc8inx 166 2 to to IN cord-010092-uftc8inx 166 3 recent recent JJ cord-010092-uftc8inx 166 4 research research NN cord-010092-uftc8inx 166 5 in in IN cord-010092-uftc8inx 166 6 vitro vitro FW cord-010092-uftc8inx 166 7 , , , cord-010092-uftc8inx 166 8 CFNAs cfna NNS cord-010092-uftc8inx 166 9 purified purify VBN cord-010092-uftc8inx 166 10 from from IN cord-010092-uftc8inx 166 11 blood blood NN cord-010092-uftc8inx 166 12 products product NNS cord-010092-uftc8inx 166 13 can can MD cord-010092-uftc8inx 166 14 induce induce VB cord-010092-uftc8inx 166 15 the the DT cord-010092-uftc8inx 166 16 transcription transcription NN cord-010092-uftc8inx 166 17 of of IN cord-010092-uftc8inx 166 18 inflammatory inflammatory JJ cord-010092-uftc8inx 166 19 cytokines cytokine NNS cord-010092-uftc8inx 166 20 by by IN cord-010092-uftc8inx 166 21 mononuclear mononuclear JJ cord-010092-uftc8inx 166 22 cells cell NNS cord-010092-uftc8inx 166 23 . . . cord-010092-uftc8inx 167 1 As as IN cord-010092-uftc8inx 167 2 nonhuman nonhuman NN cord-010092-uftc8inx 167 3 CFNA CFNA NNP cord-010092-uftc8inx 167 4 have have VBP cord-010092-uftc8inx 167 5 an an DT cord-010092-uftc8inx 167 6 effect effect NN cord-010092-uftc8inx 167 7 on on IN cord-010092-uftc8inx 167 8 Toll Toll NNP cord-010092-uftc8inx 167 9 - - HYPH cord-010092-uftc8inx 167 10 Like like JJ cord-010092-uftc8inx 167 11 Receptors receptor NNS cord-010092-uftc8inx 167 12 ( ( -LRB- cord-010092-uftc8inx 167 13 TLR TLR NNP cord-010092-uftc8inx 167 14 - - HYPH cord-010092-uftc8inx 167 15 linked link VBN cord-010092-uftc8inx 167 16 inflammatory inflammatory JJ cord-010092-uftc8inx 167 17 pathways pathway NNS cord-010092-uftc8inx 167 18 ) ) -RRB- cord-010092-uftc8inx 167 19 , , , cord-010092-uftc8inx 167 20 it -PRON- PRP cord-010092-uftc8inx 167 21 would would MD cord-010092-uftc8inx 167 22 be be VB cord-010092-uftc8inx 167 23 also also RB cord-010092-uftc8inx 167 24 relevant relevant JJ cord-010092-uftc8inx 167 25 to to TO cord-010092-uftc8inx 167 26 insure insure VB cord-010092-uftc8inx 167 27 that that DT cord-010092-uftc8inx 167 28 donor donor NN cord-010092-uftc8inx 167 29 's 's POS cord-010092-uftc8inx 167 30 CFNAs cfna NNS cord-010092-uftc8inx 167 31 have have VBP cord-010092-uftc8inx 167 32 no no DT cord-010092-uftc8inx 167 33 significant significant JJ cord-010092-uftc8inx 167 34 effect effect NN cord-010092-uftc8inx 167 35 on on IN cord-010092-uftc8inx 167 36 the the DT cord-010092-uftc8inx 167 37 immune immune JJ cord-010092-uftc8inx 167 38 system system NN cord-010092-uftc8inx 167 39 of of IN cord-010092-uftc8inx 167 40 the the DT cord-010092-uftc8inx 167 41 recipient recipient NN cord-010092-uftc8inx 167 42 . . . cord-010092-uftc8inx 168 1 In in IN cord-010092-uftc8inx 168 2 conclusion conclusion NN cord-010092-uftc8inx 168 3 , , , cord-010092-uftc8inx 168 4 CFNAs cfna NNS cord-010092-uftc8inx 168 5 are be VBP cord-010092-uftc8inx 168 6 very very RB cord-010092-uftc8inx 168 7 diverse diverse JJ cord-010092-uftc8inx 168 8 molecules molecule NNS cord-010092-uftc8inx 168 9 contaminating contaminate VBG cord-010092-uftc8inx 168 10 blood blood NN cord-010092-uftc8inx 168 11 products product NNS cord-010092-uftc8inx 168 12 . . . cord-010092-uftc8inx 169 1 Technological technological JJ cord-010092-uftc8inx 169 2 progress progress NN cord-010092-uftc8inx 169 3 makes make VBZ cord-010092-uftc8inx 169 4 now now RB cord-010092-uftc8inx 169 5 their -PRON- PRP$ cord-010092-uftc8inx 169 6 investigation investigation NN cord-010092-uftc8inx 169 7 more more RBR cord-010092-uftc8inx 169 8 available available JJ cord-010092-uftc8inx 169 9 . . . cord-010092-uftc8inx 170 1 Besides besides IN cord-010092-uftc8inx 170 2 being be VBG cord-010092-uftc8inx 170 3 useful useful JJ cord-010092-uftc8inx 170 4 markers marker NNS cord-010092-uftc8inx 170 5 of of IN cord-010092-uftc8inx 170 6 infection infection NN cord-010092-uftc8inx 170 7 in in IN cord-010092-uftc8inx 170 8 asymptomatic asymptomatic JJ cord-010092-uftc8inx 170 9 donors donor NNS cord-010092-uftc8inx 170 10 , , , cord-010092-uftc8inx 170 11 their -PRON- PRP$ cord-010092-uftc8inx 170 12 impact impact NN cord-010092-uftc8inx 170 13 on on IN cord-010092-uftc8inx 170 14 the the DT cord-010092-uftc8inx 170 15 recipients recipient NNS cord-010092-uftc8inx 170 16 ' ' POS cord-010092-uftc8inx 170 17 immunity immunity NN cord-010092-uftc8inx 170 18 should should MD cord-010092-uftc8inx 170 19 be be VB cord-010092-uftc8inx 170 20 further further RB cord-010092-uftc8inx 170 21 investigated investigate VBN cord-010092-uftc8inx 170 22 . . . cord-010092-uftc8inx 171 1 An an DT cord-010092-uftc8inx 171 2 active active JJ cord-010092-uftc8inx 171 3 life life NN cord-010092-uftc8inx 171 4 and and CC cord-010092-uftc8inx 171 5 regular regular JJ cord-010092-uftc8inx 171 6 training training NN cord-010092-uftc8inx 171 7 is be VBZ cord-010092-uftc8inx 171 8 part part NN cord-010092-uftc8inx 171 9 of of IN cord-010092-uftc8inx 171 10 a a DT cord-010092-uftc8inx 171 11 healthy healthy JJ cord-010092-uftc8inx 171 12 life life NN cord-010092-uftc8inx 171 13 style style NN cord-010092-uftc8inx 171 14 and and CC cord-010092-uftc8inx 171 15 for for IN cord-010092-uftc8inx 171 16 many many JJ cord-010092-uftc8inx 171 17 this this DT cord-010092-uftc8inx 171 18 includes include VBZ cord-010092-uftc8inx 171 19 participation participation NN cord-010092-uftc8inx 171 20 in in IN cord-010092-uftc8inx 171 21 endurance endurance NN cord-010092-uftc8inx 171 22 exercise exercise NN cord-010092-uftc8inx 171 23 competition competition NN cord-010092-uftc8inx 171 24 at at IN cord-010092-uftc8inx 171 25 different different JJ cord-010092-uftc8inx 171 26 levels level NNS cord-010092-uftc8inx 171 27 . . . cord-010092-uftc8inx 172 1 Thus thus RB cord-010092-uftc8inx 172 2 , , , cord-010092-uftc8inx 172 3 it -PRON- PRP cord-010092-uftc8inx 172 4 is be VBZ cord-010092-uftc8inx 172 5 highly highly RB cord-010092-uftc8inx 172 6 relevant relevant JJ cord-010092-uftc8inx 172 7 to to TO cord-010092-uftc8inx 172 8 know know VB cord-010092-uftc8inx 172 9 how how WRB cord-010092-uftc8inx 172 10 a a DT cord-010092-uftc8inx 172 11 blood blood NN cord-010092-uftc8inx 172 12 donation donation NN cord-010092-uftc8inx 172 13 affects affect VBZ cord-010092-uftc8inx 172 14 exercise exercise NN cord-010092-uftc8inx 172 15 performance performance NN cord-010092-uftc8inx 172 16 and and CC cord-010092-uftc8inx 172 17 how how WRB cord-010092-uftc8inx 172 18 close close JJ cord-010092-uftc8inx 172 19 this this DT cord-010092-uftc8inx 172 20 can can MD cord-010092-uftc8inx 172 21 done do VBN cord-010092-uftc8inx 172 22 to to IN cord-010092-uftc8inx 172 23 an an DT cord-010092-uftc8inx 172 24 endurance endurance NN cord-010092-uftc8inx 172 25 competition competition NN cord-010092-uftc8inx 172 26 . . . cord-010092-uftc8inx 173 1 Endurance endurance NN cord-010092-uftc8inx 173 2 exercise exercise NN cord-010092-uftc8inx 173 3 performance performance NN cord-010092-uftc8inx 173 4 is be VBZ cord-010092-uftc8inx 173 5 determined determine VBN cord-010092-uftc8inx 173 6 by by IN cord-010092-uftc8inx 173 7 many many JJ cord-010092-uftc8inx 173 8 factors factor NNS cord-010092-uftc8inx 173 9 , , , cord-010092-uftc8inx 173 10 but but CC cord-010092-uftc8inx 173 11 three three CD cord-010092-uftc8inx 173 12 of of IN cord-010092-uftc8inx 173 13 the the DT cord-010092-uftc8inx 173 14 primary primary NN cord-010092-uftc8inx 173 15 are be VBP cord-010092-uftc8inx 173 16 maximal maximal JJ cord-010092-uftc8inx 173 17 oxygen oxygen NN cord-010092-uftc8inx 173 18 uptake uptake NN cord-010092-uftc8inx 173 19 , , , cord-010092-uftc8inx 173 20 the the DT cord-010092-uftc8inx 173 21 relative relative JJ cord-010092-uftc8inx 173 22 load load NN cord-010092-uftc8inx 173 23 that that WDT cord-010092-uftc8inx 173 24 an an DT cord-010092-uftc8inx 173 25 individual individual NN cord-010092-uftc8inx 173 26 can can MD cord-010092-uftc8inx 173 27 sustain sustain VB cord-010092-uftc8inx 173 28 over over IN cord-010092-uftc8inx 173 29 time time NN cord-010092-uftc8inx 173 30 and and CC cord-010092-uftc8inx 173 31 finally finally RB cord-010092-uftc8inx 173 32 the the DT cord-010092-uftc8inx 173 33 efficiency efficiency NN cord-010092-uftc8inx 173 34 of of IN cord-010092-uftc8inx 173 35 movement movement NN cord-010092-uftc8inx 173 36 in in IN cord-010092-uftc8inx 173 37 the the DT cord-010092-uftc8inx 173 38 given give VBN cord-010092-uftc8inx 173 39 discipline discipline NN cord-010092-uftc8inx 173 40 . . . cord-010092-uftc8inx 174 1 Over over IN cord-010092-uftc8inx 174 2 the the DT cord-010092-uftc8inx 174 3 years year NNS cord-010092-uftc8inx 174 4 , , , cord-010092-uftc8inx 174 5 a a DT cord-010092-uftc8inx 174 6 number number NN cord-010092-uftc8inx 174 7 of of IN cord-010092-uftc8inx 174 8 studies study NNS cord-010092-uftc8inx 174 9 have have VBP cord-010092-uftc8inx 174 10 sampled sample VBN cord-010092-uftc8inx 174 11 blood blood NN cord-010092-uftc8inx 174 12 volumes volume NNS cord-010092-uftc8inx 174 13 ranging range VBG cord-010092-uftc8inx 174 14 from from IN cord-010092-uftc8inx 174 15 450 450 CD cord-010092-uftc8inx 174 16 - - SYM cord-010092-uftc8inx 174 17 1200 1200 CD cord-010092-uftc8inx 174 18 ml ml NNS cord-010092-uftc8inx 174 19 and and CC cord-010092-uftc8inx 174 20 applied apply VBD cord-010092-uftc8inx 174 21 different different JJ cord-010092-uftc8inx 174 22 methodological methodological JJ cord-010092-uftc8inx 174 23 approaches approach NNS cord-010092-uftc8inx 174 24 to to TO cord-010092-uftc8inx 174 25 measure measure VB cord-010092-uftc8inx 174 26 maximal maximal JJ cord-010092-uftc8inx 174 27 oxygen oxygen NN cord-010092-uftc8inx 174 28 uptake uptake NN cord-010092-uftc8inx 174 29 over over IN cord-010092-uftc8inx 174 30 a a DT cord-010092-uftc8inx 174 31 recovery recovery NN cord-010092-uftc8inx 174 32 period period NN cord-010092-uftc8inx 174 33 ranging range VBG cord-010092-uftc8inx 174 34 between between IN cord-010092-uftc8inx 174 35 3 3 CD cord-010092-uftc8inx 174 36 - - SYM cord-010092-uftc8inx 174 37 28 28 CD cord-010092-uftc8inx 174 38 days day NNS cord-010092-uftc8inx 174 39 . . . cord-010092-uftc8inx 175 1 Overall overall RB cord-010092-uftc8inx 175 2 , , , cord-010092-uftc8inx 175 3 the the DT cord-010092-uftc8inx 175 4 general general JJ cord-010092-uftc8inx 175 5 finding finding NN cord-010092-uftc8inx 175 6 is be VBZ cord-010092-uftc8inx 175 7 a a DT cord-010092-uftc8inx 175 8 reduction reduction NN cord-010092-uftc8inx 175 9 in in IN cord-010092-uftc8inx 175 10 blood blood NN cord-010092-uftc8inx 175 11 haemoglobin haemoglobin NN cord-010092-uftc8inx 175 12 and and CC cord-010092-uftc8inx 175 13 an an DT cord-010092-uftc8inx 175 14 attenuated attenuated JJ cord-010092-uftc8inx 175 15 maximal maximal JJ cord-010092-uftc8inx 175 16 oxygen oxygen NN cord-010092-uftc8inx 175 17 uptake uptake NN cord-010092-uftc8inx 175 18 as as IN cord-010092-uftc8inx 175 19 well well RB cord-010092-uftc8inx 175 20 endurance endurance NN cord-010092-uftc8inx 175 21 performance performance NN cord-010092-uftc8inx 175 22 after after IN cord-010092-uftc8inx 175 23 blood blood NN cord-010092-uftc8inx 175 24 donation donation NN cord-010092-uftc8inx 175 25 . . . cord-010092-uftc8inx 176 1 In in IN cord-010092-uftc8inx 176 2 normal normal JJ cord-010092-uftc8inx 176 3 to to IN cord-010092-uftc8inx 176 4 well well RB cord-010092-uftc8inx 176 5 - - HYPH cord-010092-uftc8inx 176 6 trained train VBN cord-010092-uftc8inx 176 7 men man NNS cord-010092-uftc8inx 176 8 maximal maximal JJ cord-010092-uftc8inx 176 9 oxygen oxygen NN cord-010092-uftc8inx 176 10 uptake uptake NN cord-010092-uftc8inx 176 11 and and CC cord-010092-uftc8inx 176 12 performance performance NN cord-010092-uftc8inx 176 13 was be VBD cord-010092-uftc8inx 176 14 normalized normalize VBN cord-010092-uftc8inx 176 15 after after IN cord-010092-uftc8inx 176 16 two two CD cord-010092-uftc8inx 176 17 weeks week NNS cord-010092-uftc8inx 176 18 in in IN cord-010092-uftc8inx 176 19 one one CD cord-010092-uftc8inx 176 20 study study NN cord-010092-uftc8inx 176 21 after after IN cord-010092-uftc8inx 176 22 a a DT cord-010092-uftc8inx 176 23 normal normal JJ cord-010092-uftc8inx 176 24 blood blood NN cord-010092-uftc8inx 176 25 donation donation NN cord-010092-uftc8inx 176 26 ( ( -LRB- cord-010092-uftc8inx 176 27 450/470 450/470 CD cord-010092-uftc8inx 176 28 ml ml NN cord-010092-uftc8inx 176 29 ) ) -RRB- cord-010092-uftc8inx 176 30 , , , cord-010092-uftc8inx 176 31 but but CC cord-010092-uftc8inx 176 32 remained remain VBD cord-010092-uftc8inx 176 33 attenuated attenuated JJ cord-010092-uftc8inx 176 34 after after IN cord-010092-uftc8inx 176 35 four four CD cord-010092-uftc8inx 176 36 weeks week NNS cord-010092-uftc8inx 176 37 in in IN cord-010092-uftc8inx 176 38 another another DT cord-010092-uftc8inx 176 39 study study NN cord-010092-uftc8inx 176 40 , , , cord-010092-uftc8inx 176 41 despite despite IN cord-010092-uftc8inx 176 42 the the DT cord-010092-uftc8inx 176 43 change change NN cord-010092-uftc8inx 176 44 in in IN cord-010092-uftc8inx 176 45 blood blood NN cord-010092-uftc8inx 176 46 haemoglobin haemoglobin NN cord-010092-uftc8inx 176 47 concentration concentration NN cord-010092-uftc8inx 176 48 was be VBD cord-010092-uftc8inx 176 49 similar similar JJ cord-010092-uftc8inx 176 50 and and CC cord-010092-uftc8inx 176 51 the the DT cord-010092-uftc8inx 176 52 design design NN cord-010092-uftc8inx 176 53 and and CC cord-010092-uftc8inx 176 54 methodology methodology NN cord-010092-uftc8inx 176 55 also also RB cord-010092-uftc8inx 176 56 similar similar JJ cord-010092-uftc8inx 176 57 in in IN cord-010092-uftc8inx 176 58 the the DT cord-010092-uftc8inx 176 59 two two CD cord-010092-uftc8inx 176 60 studies study NNS cord-010092-uftc8inx 176 61 . . . cord-010092-uftc8inx 177 1 In in IN cord-010092-uftc8inx 177 2 addition addition NN cord-010092-uftc8inx 177 3 to to IN cord-010092-uftc8inx 177 4 maximal maximal JJ cord-010092-uftc8inx 177 5 oxygen oxygen NN cord-010092-uftc8inx 177 6 uptake uptake NN cord-010092-uftc8inx 177 7 the the DT cord-010092-uftc8inx 177 8 relative relative JJ cord-010092-uftc8inx 177 9 load load NN cord-010092-uftc8inx 177 10 that that WDT cord-010092-uftc8inx 177 11 can can MD cord-010092-uftc8inx 177 12 be be VB cord-010092-uftc8inx 177 13 tolerated tolerate VBN cord-010092-uftc8inx 177 14 during during IN cord-010092-uftc8inx 177 15 exercise exercise NN cord-010092-uftc8inx 177 16 is be VBZ cord-010092-uftc8inx 177 17 probably probably RB cord-010092-uftc8inx 177 18 also also RB cord-010092-uftc8inx 177 19 attenuated attenuate VBN cord-010092-uftc8inx 177 20 , , , cord-010092-uftc8inx 177 21 through through IN cord-010092-uftc8inx 177 22 a a DT cord-010092-uftc8inx 177 23 decreased decrease VBN cord-010092-uftc8inx 177 24 arterio arterio NN cord-010092-uftc8inx 177 25 - - HYPH cord-010092-uftc8inx 177 26 venous venous JJ cord-010092-uftc8inx 177 27 oxygen oxygen NN cord-010092-uftc8inx 177 28 extraction extraction NN cord-010092-uftc8inx 177 29 , , , cord-010092-uftc8inx 177 30 but but CC cord-010092-uftc8inx 177 31 the the DT cord-010092-uftc8inx 177 32 available available JJ cord-010092-uftc8inx 177 33 data data NN cord-010092-uftc8inx 177 34 is be VBZ cord-010092-uftc8inx 177 35 very very RB cord-010092-uftc8inx 177 36 limited limited JJ cord-010092-uftc8inx 177 37 . . . cord-010092-uftc8inx 178 1 The the DT cord-010092-uftc8inx 178 2 first first JJ cord-010092-uftc8inx 178 3 part part NN cord-010092-uftc8inx 178 4 of of IN cord-010092-uftc8inx 178 5 this this DT cord-010092-uftc8inx 178 6 talk talk NN cord-010092-uftc8inx 178 7 will will MD cord-010092-uftc8inx 178 8 highlight highlight VB cord-010092-uftc8inx 178 9 the the DT cord-010092-uftc8inx 178 10 major major JJ cord-010092-uftc8inx 178 11 findings finding NNS cord-010092-uftc8inx 178 12 and and CC cord-010092-uftc8inx 178 13 discuss discuss VB cord-010092-uftc8inx 178 14 some some DT cord-010092-uftc8inx 178 15 of of IN cord-010092-uftc8inx 178 16 the the DT cord-010092-uftc8inx 178 17 methodological methodological JJ cord-010092-uftc8inx 178 18 issues issue NNS cord-010092-uftc8inx 178 19 that that WDT cord-010092-uftc8inx 178 20 complicate complicate VBP cord-010092-uftc8inx 178 21 interpretation interpretation NN cord-010092-uftc8inx 178 22 and and CC cord-010092-uftc8inx 178 23 conclusions conclusion NNS cord-010092-uftc8inx 178 24 . . . cord-010092-uftc8inx 179 1 There there EX cord-010092-uftc8inx 179 2 are be VBP cord-010092-uftc8inx 179 3 sex sex NN cord-010092-uftc8inx 179 4 differences difference NNS cord-010092-uftc8inx 179 5 in in IN cord-010092-uftc8inx 179 6 circulating circulate VBG cord-010092-uftc8inx 179 7 blood blood NN cord-010092-uftc8inx 179 8 volume volume NN cord-010092-uftc8inx 179 9 , , , cord-010092-uftc8inx 179 10 haemoglobin haemoglobin NN cord-010092-uftc8inx 179 11 concentration concentration NN cord-010092-uftc8inx 179 12 , , , cord-010092-uftc8inx 179 13 haematocrit haematocrit NNP cord-010092-uftc8inx 179 14 and and CC cord-010092-uftc8inx 179 15 hormone hormone NN cord-010092-uftc8inx 179 16 levels level NNS cord-010092-uftc8inx 179 17 and and CC cord-010092-uftc8inx 179 18 thus thus RB cord-010092-uftc8inx 179 19 it -PRON- PRP cord-010092-uftc8inx 179 20 is be VBZ cord-010092-uftc8inx 179 21 entirely entirely RB cord-010092-uftc8inx 179 22 possible possible JJ cord-010092-uftc8inx 179 23 that that IN cord-010092-uftc8inx 179 24 there there EX cord-010092-uftc8inx 179 25 is be VBZ cord-010092-uftc8inx 179 26 a a DT cord-010092-uftc8inx 179 27 sex sex NN cord-010092-uftc8inx 179 28 difference difference NN cord-010092-uftc8inx 179 29 in in IN cord-010092-uftc8inx 179 30 the the DT cord-010092-uftc8inx 179 31 effect effect NN cord-010092-uftc8inx 179 32 of of IN cord-010092-uftc8inx 179 33 blood blood NN cord-010092-uftc8inx 179 34 donation donation NN cord-010092-uftc8inx 179 35 on on IN cord-010092-uftc8inx 179 36 physical physical JJ cord-010092-uftc8inx 179 37 performance performance NN cord-010092-uftc8inx 179 38 and and CC cord-010092-uftc8inx 179 39 the the DT cord-010092-uftc8inx 179 40 recovery recovery NN cord-010092-uftc8inx 179 41 after after IN cord-010092-uftc8inx 179 42 blood blood NN cord-010092-uftc8inx 179 43 donation donation NN cord-010092-uftc8inx 179 44 . . . cord-010092-uftc8inx 180 1 In in IN cord-010092-uftc8inx 180 2 addition addition NN cord-010092-uftc8inx 180 3 to to IN cord-010092-uftc8inx 180 4 the the DT cord-010092-uftc8inx 180 5 basic basic JJ cord-010092-uftc8inx 180 6 physiological physiological JJ cord-010092-uftc8inx 180 7 sex sex NN cord-010092-uftc8inx 180 8 differences difference NNS cord-010092-uftc8inx 180 9 , , , cord-010092-uftc8inx 180 10 there there EX cord-010092-uftc8inx 180 11 is be VBZ cord-010092-uftc8inx 180 12 also also RB cord-010092-uftc8inx 180 13 a a DT cord-010092-uftc8inx 180 14 higher high JJR cord-010092-uftc8inx 180 15 prevalence prevalence NN cord-010092-uftc8inx 180 16 of of IN cord-010092-uftc8inx 180 17 iron iron NN cord-010092-uftc8inx 180 18 deficiency deficiency NN cord-010092-uftc8inx 180 19 in in IN cord-010092-uftc8inx 180 20 premenopausal premenopausal JJ cord-010092-uftc8inx 180 21 women woman NNS cord-010092-uftc8inx 180 22 , , , cord-010092-uftc8inx 180 23 physically physically RB cord-010092-uftc8inx 180 24 active active JJ cord-010092-uftc8inx 180 25 women woman NNS cord-010092-uftc8inx 180 26 and and CC cord-010092-uftc8inx 180 27 women woman NNS cord-010092-uftc8inx 180 28 donating donate VBG cord-010092-uftc8inx 180 29 blood blood NN cord-010092-uftc8inx 180 30 . . . cord-010092-uftc8inx 181 1 Therefore therefore RB cord-010092-uftc8inx 181 2 , , , cord-010092-uftc8inx 181 3 we -PRON- PRP cord-010092-uftc8inx 181 4 studied study VBD cord-010092-uftc8inx 181 5 the the DT cord-010092-uftc8inx 181 6 influence influence NN cord-010092-uftc8inx 181 7 of of IN cord-010092-uftc8inx 181 8 a a DT cord-010092-uftc8inx 181 9 standard standard JJ cord-010092-uftc8inx 181 10 450 450 CD cord-010092-uftc8inx 181 11 mL ml NN cord-010092-uftc8inx 181 12 blood blood NN cord-010092-uftc8inx 181 13 donation donation NN cord-010092-uftc8inx 181 14 on on IN cord-010092-uftc8inx 181 15 maximal maximal JJ cord-010092-uftc8inx 181 16 oxygen oxygen NN cord-010092-uftc8inx 181 17 uptake uptake NN cord-010092-uftc8inx 181 18 and and CC cord-010092-uftc8inx 181 19 endurance endurance NN cord-010092-uftc8inx 181 20 performance performance NN cord-010092-uftc8inx 181 21 and and CC cord-010092-uftc8inx 181 22 the the DT cord-010092-uftc8inx 181 23 subsequent subsequent JJ cord-010092-uftc8inx 181 24 recovery recovery NN cord-010092-uftc8inx 181 25 in in IN cord-010092-uftc8inx 181 26 physically physically RB cord-010092-uftc8inx 181 27 active active JJ cord-010092-uftc8inx 181 28 women woman NNS cord-010092-uftc8inx 181 29 . . . cord-010092-uftc8inx 182 1 We -PRON- PRP cord-010092-uftc8inx 182 2 observed observe VBD cord-010092-uftc8inx 182 3 that that IN cord-010092-uftc8inx 182 4 in in IN cord-010092-uftc8inx 182 5 iron iron NN cord-010092-uftc8inx 182 6 sufficient sufficient JJ cord-010092-uftc8inx 182 7 women woman NNS cord-010092-uftc8inx 182 8 blood blood NN cord-010092-uftc8inx 182 9 haemoglobin haemoglobin NN cord-010092-uftc8inx 182 10 concentration concentration NN cord-010092-uftc8inx 182 11 and and CC cord-010092-uftc8inx 182 12 maximal maximal JJ cord-010092-uftc8inx 182 13 oxygen oxygen NN cord-010092-uftc8inx 182 14 uptake uptake NN cord-010092-uftc8inx 182 15 were be VBD cord-010092-uftc8inx 182 16 back back RB cord-010092-uftc8inx 182 17 to to IN cord-010092-uftc8inx 182 18 baseline baseline JJ cord-010092-uftc8inx 182 19 28 28 CD cord-010092-uftc8inx 182 20 days day NNS cord-010092-uftc8inx 182 21 after after IN cord-010092-uftc8inx 182 22 blood blood NN cord-010092-uftc8inx 182 23 donation donation NN cord-010092-uftc8inx 182 24 , , , cord-010092-uftc8inx 182 25 but but CC cord-010092-uftc8inx 182 26 endurance endurance NN cord-010092-uftc8inx 182 27 performance performance NN cord-010092-uftc8inx 182 28 was be VBD cord-010092-uftc8inx 182 29 normalized normalize VBN cord-010092-uftc8inx 182 30 already already RB cord-010092-uftc8inx 182 31 after after IN cord-010092-uftc8inx 182 32 14 14 CD cord-010092-uftc8inx 182 33 days day NNS cord-010092-uftc8inx 182 34 . . . cord-010092-uftc8inx 183 1 The the DT cord-010092-uftc8inx 183 2 second second JJ cord-010092-uftc8inx 183 3 part part NN cord-010092-uftc8inx 183 4 of of IN cord-010092-uftc8inx 183 5 this this DT cord-010092-uftc8inx 183 6 talk talk NN cord-010092-uftc8inx 183 7 will will MD cord-010092-uftc8inx 183 8 discuss discuss VB cord-010092-uftc8inx 183 9 the the DT cord-010092-uftc8inx 183 10 sex sex NN cord-010092-uftc8inx 183 11 differences difference NNS cord-010092-uftc8inx 183 12 in in IN cord-010092-uftc8inx 183 13 the the DT cord-010092-uftc8inx 183 14 effect effect NN cord-010092-uftc8inx 183 15 of of IN cord-010092-uftc8inx 183 16 blood blood NN cord-010092-uftc8inx 183 17 donation donation NN cord-010092-uftc8inx 183 18 on on IN cord-010092-uftc8inx 183 19 maximal maximal JJ cord-010092-uftc8inx 183 20 oxygen oxygen NN cord-010092-uftc8inx 183 21 uptake uptake NN cord-010092-uftc8inx 183 22 and and CC cord-010092-uftc8inx 183 23 endurance endurance NN cord-010092-uftc8inx 183 24 performance performance NN cord-010092-uftc8inx 183 25 . . . cord-010092-uftc8inx 184 1 Overall overall RB cord-010092-uftc8inx 184 2 , , , cord-010092-uftc8inx 184 3 the the DT cord-010092-uftc8inx 184 4 available available JJ cord-010092-uftc8inx 184 5 data datum NNS cord-010092-uftc8inx 184 6 suggest suggest VBP cord-010092-uftc8inx 184 7 that that IN cord-010092-uftc8inx 184 8 , , , cord-010092-uftc8inx 184 9 with with IN cord-010092-uftc8inx 184 10 a a DT cord-010092-uftc8inx 184 11 careful careful JJ cord-010092-uftc8inx 184 12 conservative conservative JJ cord-010092-uftc8inx 184 13 approach approach NN cord-010092-uftc8inx 184 14 , , , cord-010092-uftc8inx 184 15 4 4 CD cord-010092-uftc8inx 184 16 -5 -5 CD cord-010092-uftc8inx 184 17 weeks week NNS cord-010092-uftc8inx 184 18 are be VBP cord-010092-uftc8inx 184 19 needed need VBN cord-010092-uftc8inx 184 20 after after IN cord-010092-uftc8inx 184 21 a a DT cord-010092-uftc8inx 184 22 normal normal JJ cord-010092-uftc8inx 184 23 blood blood NN cord-010092-uftc8inx 184 24 donation donation NN cord-010092-uftc8inx 184 25 to to TO cord-010092-uftc8inx 184 26 be be VB cord-010092-uftc8inx 184 27 fully fully RB cord-010092-uftc8inx 184 28 recovered recover VBN cord-010092-uftc8inx 184 29 to to TO cord-010092-uftc8inx 184 30 participate participate VB cord-010092-uftc8inx 184 31 in in IN cord-010092-uftc8inx 184 32 endurance endurance NN cord-010092-uftc8inx 184 33 exercise exercise NN cord-010092-uftc8inx 184 34 competitions competition NNS cord-010092-uftc8inx 184 35 . . . cord-010092-uftc8inx 185 1 More More JJR cord-010092-uftc8inx 185 2 than than IN cord-010092-uftc8inx 185 3 one one CD cord-010092-uftc8inx 185 4 in in IN cord-010092-uftc8inx 185 5 ten ten CD cord-010092-uftc8inx 185 6 attempts attempt NNS cord-010092-uftc8inx 185 7 to to TO cord-010092-uftc8inx 185 8 donate donate VB cord-010092-uftc8inx 185 9 blood blood NN cord-010092-uftc8inx 185 10 result result NN cord-010092-uftc8inx 185 11 in in IN cord-010092-uftc8inx 185 12 a a DT cord-010092-uftc8inx 185 13 temporary temporary JJ cord-010092-uftc8inx 185 14 deferral deferral NN cord-010092-uftc8inx 185 15 , , , cord-010092-uftc8inx 185 16 due due IN cord-010092-uftc8inx 185 17 to to IN cord-010092-uftc8inx 185 18 concerns concern NNS cord-010092-uftc8inx 185 19 about about IN cord-010092-uftc8inx 185 20 the the DT cord-010092-uftc8inx 185 21 impact impact NN cord-010092-uftc8inx 185 22 of of IN cord-010092-uftc8inx 185 23 the the DT cord-010092-uftc8inx 185 24 donation donation NN cord-010092-uftc8inx 185 25 on on IN cord-010092-uftc8inx 185 26 the the DT cord-010092-uftc8inx 185 27 donor donor NN cord-010092-uftc8inx 185 28 or or CC cord-010092-uftc8inx 185 29 recipient recipient NN cord-010092-uftc8inx 185 30 . . . cord-010092-uftc8inx 186 1 There there EX cord-010092-uftc8inx 186 2 is be VBZ cord-010092-uftc8inx 186 3 well well RB cord-010092-uftc8inx 186 4 established establish VBN cord-010092-uftc8inx 186 5 evidence evidence NN cord-010092-uftc8inx 186 6 that that IN cord-010092-uftc8inx 186 7 temporary temporary JJ cord-010092-uftc8inx 186 8 deferrals deferral NNS cord-010092-uftc8inx 186 9 impact impact VBP cord-010092-uftc8inx 186 10 negatively negatively RB cord-010092-uftc8inx 186 11 on on IN cord-010092-uftc8inx 186 12 donors donor NNS cord-010092-uftc8inx 186 13 , , , cord-010092-uftc8inx 186 14 with with IN cord-010092-uftc8inx 186 15 a a DT cord-010092-uftc8inx 186 16 large large JJ cord-010092-uftc8inx 186 17 proportion proportion NN cord-010092-uftc8inx 186 18 of of IN cord-010092-uftc8inx 186 19 those those DT cord-010092-uftc8inx 186 20 deferred defer VBN cord-010092-uftc8inx 186 21 failing fail VBG cord-010092-uftc8inx 186 22 to to TO cord-010092-uftc8inx 186 23 return return VB cord-010092-uftc8inx 186 24 at at IN cord-010092-uftc8inx 186 25 the the DT cord-010092-uftc8inx 186 26 end end NN cord-010092-uftc8inx 186 27 of of IN cord-010092-uftc8inx 186 28 the the DT cord-010092-uftc8inx 186 29 deferral deferral NN cord-010092-uftc8inx 186 30 period period NN cord-010092-uftc8inx 186 31 . . . cord-010092-uftc8inx 187 1 This this DT cord-010092-uftc8inx 187 2 presentation presentation NN cord-010092-uftc8inx 187 3 provides provide VBZ cord-010092-uftc8inx 187 4 an an DT cord-010092-uftc8inx 187 5 overview overview NN cord-010092-uftc8inx 187 6 of of IN cord-010092-uftc8inx 187 7 deferrals deferral NNS cord-010092-uftc8inx 187 8 from from IN cord-010092-uftc8inx 187 9 the the DT cord-010092-uftc8inx 187 10 donor donor NN cord-010092-uftc8inx 187 11 perspective perspective NN cord-010092-uftc8inx 187 12 , , , cord-010092-uftc8inx 187 13 describing describe VBG cord-010092-uftc8inx 187 14 the the DT cord-010092-uftc8inx 187 15 likelihood likelihood NN cord-010092-uftc8inx 187 16 of of IN cord-010092-uftc8inx 187 17 receiving receive VBG cord-010092-uftc8inx 187 18 a a DT cord-010092-uftc8inx 187 19 deferral deferral NN cord-010092-uftc8inx 187 20 for for IN cord-010092-uftc8inx 187 21 different different JJ cord-010092-uftc8inx 187 22 donor donor NN cord-010092-uftc8inx 187 23 subgroups subgroup NNS cord-010092-uftc8inx 187 24 . . . cord-010092-uftc8inx 188 1 The the DT cord-010092-uftc8inx 188 2 impact impact NN cord-010092-uftc8inx 188 3 of of IN cord-010092-uftc8inx 188 4 temporary temporary JJ cord-010092-uftc8inx 188 5 deferrals deferral NNS cord-010092-uftc8inx 188 6 on on IN cord-010092-uftc8inx 188 7 the the DT cord-010092-uftc8inx 188 8 future future JJ cord-010092-uftc8inx 188 9 donation donation NN cord-010092-uftc8inx 188 10 of of IN cord-010092-uftc8inx 188 11 donors donor NNS cord-010092-uftc8inx 188 12 , , , cord-010092-uftc8inx 188 13 considering consider VBG cord-010092-uftc8inx 188 14 both both DT cord-010092-uftc8inx 188 15 short short JJ cord-010092-uftc8inx 188 16 - - HYPH cord-010092-uftc8inx 188 17 term term NN cord-010092-uftc8inx 188 18 and and CC cord-010092-uftc8inx 188 19 longer long JJR cord-010092-uftc8inx 188 20 - - HYPH cord-010092-uftc8inx 188 21 term term NN cord-010092-uftc8inx 188 22 donation donation NN cord-010092-uftc8inx 188 23 patterns pattern NNS cord-010092-uftc8inx 188 24 , , , cord-010092-uftc8inx 188 25 will will MD cord-010092-uftc8inx 188 26 also also RB cord-010092-uftc8inx 188 27 be be VB cord-010092-uftc8inx 188 28 reviewed review VBN cord-010092-uftc8inx 188 29 , , , cord-010092-uftc8inx 188 30 outlining outline VBG cord-010092-uftc8inx 188 31 which which WDT cord-010092-uftc8inx 188 32 donors donor NNS cord-010092-uftc8inx 188 33 are be VBP cord-010092-uftc8inx 188 34 at at IN cord-010092-uftc8inx 188 35 highest high JJS cord-010092-uftc8inx 188 36 risk risk NN cord-010092-uftc8inx 188 37 of of IN cord-010092-uftc8inx 188 38 non non JJ cord-010092-uftc8inx 188 39 - - JJ cord-010092-uftc8inx 188 40 return return JJ cord-010092-uftc8inx 188 41 following follow VBG cord-010092-uftc8inx 188 42 a a DT cord-010092-uftc8inx 188 43 deferral deferral NN cord-010092-uftc8inx 188 44 , , , cord-010092-uftc8inx 188 45 and and CC cord-010092-uftc8inx 188 46 what what WP cord-010092-uftc8inx 188 47 is be VBZ cord-010092-uftc8inx 188 48 known know VBN cord-010092-uftc8inx 188 49 about about IN cord-010092-uftc8inx 188 50 the the DT cord-010092-uftc8inx 188 51 accumulative accumulative JJ cord-010092-uftc8inx 188 52 impact impact NN cord-010092-uftc8inx 188 53 of of IN cord-010092-uftc8inx 188 54 multiple multiple JJ cord-010092-uftc8inx 188 55 deferrals deferral NNS cord-010092-uftc8inx 188 56 on on IN cord-010092-uftc8inx 188 57 donors donor NNS cord-010092-uftc8inx 188 58 . . . cord-010092-uftc8inx 189 1 Several several JJ cord-010092-uftc8inx 189 2 hypotheses hypothesis NNS cord-010092-uftc8inx 189 3 have have VBP cord-010092-uftc8inx 189 4 been be VBN cord-010092-uftc8inx 189 5 proposed propose VBN cord-010092-uftc8inx 189 6 to to TO cord-010092-uftc8inx 189 7 account account VB cord-010092-uftc8inx 189 8 for for IN cord-010092-uftc8inx 189 9 the the DT cord-010092-uftc8inx 189 10 strong strong JJ cord-010092-uftc8inx 189 11 negative negative JJ cord-010092-uftc8inx 189 12 impact impact NN cord-010092-uftc8inx 189 13 of of IN cord-010092-uftc8inx 189 14 deferrals deferral NNS cord-010092-uftc8inx 189 15 on on IN cord-010092-uftc8inx 189 16 donor donor NN cord-010092-uftc8inx 189 17 behaviour behaviour NN cord-010092-uftc8inx 189 18 , , , cord-010092-uftc8inx 189 19 and and CC cord-010092-uftc8inx 189 20 there there EX cord-010092-uftc8inx 189 21 is be VBZ cord-010092-uftc8inx 189 22 preliminary preliminary JJ cord-010092-uftc8inx 189 23 evidence evidence NN cord-010092-uftc8inx 189 24 of of IN cord-010092-uftc8inx 189 25 psychological psychological JJ cord-010092-uftc8inx 189 26 factors factor NNS cord-010092-uftc8inx 189 27 , , , cord-010092-uftc8inx 189 28 such such JJ cord-010092-uftc8inx 189 29 as as IN cord-010092-uftc8inx 189 30 emotional emotional JJ cord-010092-uftc8inx 189 31 reactions reaction NNS cord-010092-uftc8inx 189 32 , , , cord-010092-uftc8inx 189 33 predicting predict VBG cord-010092-uftc8inx 189 34 intention intention NN cord-010092-uftc8inx 189 35 to to TO cord-010092-uftc8inx 189 36 return return VB cord-010092-uftc8inx 189 37 . . . cord-010092-uftc8inx 190 1 Research research NN cord-010092-uftc8inx 190 2 is be VBZ cord-010092-uftc8inx 190 3 also also RB cord-010092-uftc8inx 190 4 beginning begin VBG cord-010092-uftc8inx 190 5 to to TO cord-010092-uftc8inx 190 6 emerge emerge VB cord-010092-uftc8inx 190 7 on on IN cord-010092-uftc8inx 190 8 the the DT cord-010092-uftc8inx 190 9 effectiveness effectiveness NN cord-010092-uftc8inx 190 10 of of IN cord-010092-uftc8inx 190 11 tailored tailor VBN cord-010092-uftc8inx 190 12 interventions intervention NNS cord-010092-uftc8inx 190 13 to to TO cord-010092-uftc8inx 190 14 mitigate mitigate VB cord-010092-uftc8inx 190 15 the the DT cord-010092-uftc8inx 190 16 impact impact NN cord-010092-uftc8inx 190 17 of of IN cord-010092-uftc8inx 190 18 deferrals deferral NNS cord-010092-uftc8inx 190 19 on on IN cord-010092-uftc8inx 190 20 donor donor NN cord-010092-uftc8inx 190 21 behaviour behaviour NN cord-010092-uftc8inx 190 22 . . . cord-010092-uftc8inx 191 1 The the DT cord-010092-uftc8inx 191 2 evidence evidence NN cord-010092-uftc8inx 191 3 for for IN cord-010092-uftc8inx 191 4 these these DT cord-010092-uftc8inx 191 5 preventative preventative JJ cord-010092-uftc8inx 191 6 interventions intervention NNS cord-010092-uftc8inx 191 7 , , , cord-010092-uftc8inx 191 8 and and CC cord-010092-uftc8inx 191 9 for for IN cord-010092-uftc8inx 191 10 strategies strategy NNS cord-010092-uftc8inx 191 11 to to IN cord-010092-uftc8inx 191 12 reactive reactive JJ cord-010092-uftc8inx 191 13 donors donor NNS cord-010092-uftc8inx 191 14 once once IN cord-010092-uftc8inx 191 15 they -PRON- PRP cord-010092-uftc8inx 191 16 have have VBP cord-010092-uftc8inx 191 17 lapsed lapse VBN cord-010092-uftc8inx 191 18 post post JJ cord-010092-uftc8inx 191 19 - - JJ cord-010092-uftc8inx 191 20 deferral deferral NN cord-010092-uftc8inx 191 21 , , , cord-010092-uftc8inx 191 22 will will MD cord-010092-uftc8inx 191 23 be be VB cord-010092-uftc8inx 191 24 reviewed review VBN cord-010092-uftc8inx 191 25 . . . cord-010092-uftc8inx 192 1 Recommendations recommendation NNS cord-010092-uftc8inx 192 2 for for IN cord-010092-uftc8inx 192 3 blood blood NN cord-010092-uftc8inx 192 4 centres centre NNS cord-010092-uftc8inx 192 5 will will MD cord-010092-uftc8inx 192 6 be be VB cord-010092-uftc8inx 192 7 made make VBN cord-010092-uftc8inx 192 8 , , , cord-010092-uftc8inx 192 9 as as RB cord-010092-uftc8inx 192 10 well well RB cord-010092-uftc8inx 192 11 as as IN cord-010092-uftc8inx 192 12 suggestions suggestion NNS cord-010092-uftc8inx 192 13 for for IN cord-010092-uftc8inx 192 14 future future JJ cord-010092-uftc8inx 192 15 research research NN cord-010092-uftc8inx 192 16 to to TO cord-010092-uftc8inx 192 17 address address VB cord-010092-uftc8inx 192 18 continuing continue VBG cord-010092-uftc8inx 192 19 gaps gap NNS cord-010092-uftc8inx 192 20 in in IN cord-010092-uftc8inx 192 21 knowledge knowledge NN cord-010092-uftc8inx 192 22 . . . cord-010092-uftc8inx 193 1 In in IN cord-010092-uftc8inx 193 2 his -PRON- PRP$ cord-010092-uftc8inx 193 3 influential influential JJ cord-010092-uftc8inx 193 4 study study NN cord-010092-uftc8inx 193 5 " " `` cord-010092-uftc8inx 193 6 The the DT cord-010092-uftc8inx 193 7 Gift Gift NNP cord-010092-uftc8inx 193 8 Relationship relationship NN cord-010092-uftc8inx 193 9 " " '' cord-010092-uftc8inx 193 10 ( ( -LRB- cord-010092-uftc8inx 193 11 1970 1970 CD cord-010092-uftc8inx 193 12 ) ) -RRB- cord-010092-uftc8inx 193 13 , , , cord-010092-uftc8inx 193 14 Richard Richard NNP cord-010092-uftc8inx 193 15 Titmuss Titmuss NNP cord-010092-uftc8inx 193 16 coined coin VBD cord-010092-uftc8inx 193 17 the the DT cord-010092-uftc8inx 193 18 idea idea NN cord-010092-uftc8inx 193 19 of of IN cord-010092-uftc8inx 193 20 voluntary voluntary JJ cord-010092-uftc8inx 193 21 , , , cord-010092-uftc8inx 193 22 non non JJ cord-010092-uftc8inx 193 23 - - JJ cord-010092-uftc8inx 193 24 paid paid JJ cord-010092-uftc8inx 193 25 , , , cord-010092-uftc8inx 193 26 blood blood NN cord-010092-uftc8inx 193 27 donation donation NN cord-010092-uftc8inx 193 28 being be VBG cord-010092-uftc8inx 193 29 the the DT cord-010092-uftc8inx 193 30 gift gift NN cord-010092-uftc8inx 193 31 of of IN cord-010092-uftc8inx 193 32 life life NN cord-010092-uftc8inx 193 33 for for IN cord-010092-uftc8inx 193 34 a a DT cord-010092-uftc8inx 193 35 fellow fellow JJ cord-010092-uftc8inx 193 36 citizen citizen NN cord-010092-uftc8inx 193 37 . . . cord-010092-uftc8inx 194 1 This this DT cord-010092-uftc8inx 194 2 metaphor metaphor NN cord-010092-uftc8inx 194 3 has have VBZ cord-010092-uftc8inx 194 4 been be VBN cord-010092-uftc8inx 194 5 powerful powerful JJ cord-010092-uftc8inx 194 6 in in IN cord-010092-uftc8inx 194 7 mobilizing mobilize VBG cord-010092-uftc8inx 194 8 donors donor NNS cord-010092-uftc8inx 194 9 ( ( -LRB- cord-010092-uftc8inx 194 10 Busby Busby NNP cord-010092-uftc8inx 194 11 2004 2004 CD cord-010092-uftc8inx 194 12 ) ) -RRB- cord-010092-uftc8inx 194 13 . . . cord-010092-uftc8inx 195 1 It -PRON- PRP cord-010092-uftc8inx 195 2 conveys convey VBZ cord-010092-uftc8inx 195 3 a a DT cord-010092-uftc8inx 195 4 direct direct JJ cord-010092-uftc8inx 195 5 relationship relationship NN cord-010092-uftc8inx 195 6 between between IN cord-010092-uftc8inx 195 7 blood blood NN cord-010092-uftc8inx 195 8 donation donation NN cord-010092-uftc8inx 195 9 and and CC cord-010092-uftc8inx 195 10 patients patient NNS cord-010092-uftc8inx 195 11 ' ' POS cord-010092-uftc8inx 195 12 vitality vitality NN cord-010092-uftc8inx 195 13 , , , cord-010092-uftc8inx 195 14 as as RB cord-010092-uftc8inx 195 15 well well RB cord-010092-uftc8inx 195 16 as as IN cord-010092-uftc8inx 195 17 a a DT cord-010092-uftc8inx 195 18 difference difference NN cord-010092-uftc8inx 195 19 between between IN cord-010092-uftc8inx 195 20 gains gain NNS cord-010092-uftc8inx 195 21 and and CC cord-010092-uftc8inx 195 22 costs cost NNS cord-010092-uftc8inx 195 23 . . . cord-010092-uftc8inx 196 1 As as IN cord-010092-uftc8inx 196 2 the the DT cord-010092-uftc8inx 196 3 gift gift NN cord-010092-uftc8inx 196 4 of of IN cord-010092-uftc8inx 196 5 life life NN cord-010092-uftc8inx 196 6 , , , cord-010092-uftc8inx 196 7 blood blood NN cord-010092-uftc8inx 196 8 donation donation NN cord-010092-uftc8inx 196 9 is be VBZ cord-010092-uftc8inx 196 10 seen see VBN cord-010092-uftc8inx 196 11 to to TO cord-010092-uftc8inx 196 12 symbolize symbolize VB cord-010092-uftc8inx 196 13 pure pure JJ cord-010092-uftc8inx 196 14 altruism altruism NN cord-010092-uftc8inx 196 15 and and CC cord-010092-uftc8inx 196 16 promoting promote VBG cord-010092-uftc8inx 196 17 solidarity solidarity NN cord-010092-uftc8inx 196 18 between between IN cord-010092-uftc8inx 196 19 strangers stranger NNS cord-010092-uftc8inx 196 20 . . . cord-010092-uftc8inx 197 1 But but CC cord-010092-uftc8inx 197 2 can can MD cord-010092-uftc8inx 197 3 we -PRON- PRP cord-010092-uftc8inx 197 4 apply apply VB cord-010092-uftc8inx 197 5 the the DT cord-010092-uftc8inx 197 6 metaphor metaphor NN cord-010092-uftc8inx 197 7 as as RB cord-010092-uftc8inx 197 8 successfully successfully RB cord-010092-uftc8inx 197 9 into into IN cord-010092-uftc8inx 197 10 donating donate VBG cord-010092-uftc8inx 197 11 blood blood NN cord-010092-uftc8inx 197 12 for for IN cord-010092-uftc8inx 197 13 research research NN cord-010092-uftc8inx 197 14 ? ? . cord-010092-uftc8inx 198 1 We -PRON- PRP cord-010092-uftc8inx 198 2 asked ask VBD cord-010092-uftc8inx 198 3 a a DT cord-010092-uftc8inx 198 4 group group NN cord-010092-uftc8inx 198 5 of of IN cord-010092-uftc8inx 198 6 Finnish finnish JJ cord-010092-uftc8inx 198 7 blood blood NN cord-010092-uftc8inx 198 8 donors donor NNS cord-010092-uftc8inx 198 9 what what WP cord-010092-uftc8inx 198 10 they -PRON- PRP cord-010092-uftc8inx 198 11 would would MD cord-010092-uftc8inx 198 12 think think VB cord-010092-uftc8inx 198 13 if if IN cord-010092-uftc8inx 198 14 the the DT cord-010092-uftc8inx 198 15 FRC FRC NNP cord-010092-uftc8inx 198 16 Blood Blood NNP cord-010092-uftc8inx 198 17 Service Service NNP cord-010092-uftc8inx 198 18 invited invite VBD cord-010092-uftc8inx 198 19 them -PRON- PRP cord-010092-uftc8inx 198 20 to to TO cord-010092-uftc8inx 198 21 give give VB cord-010092-uftc8inx 198 22 a a DT cord-010092-uftc8inx 198 23 blood blood NN cord-010092-uftc8inx 198 24 sample sample NN cord-010092-uftc8inx 198 25 and and CC cord-010092-uftc8inx 198 26 personal personal JJ cord-010092-uftc8inx 198 27 information information NN cord-010092-uftc8inx 198 28 for for IN cord-010092-uftc8inx 198 29 research research NN cord-010092-uftc8inx 198 30 . . . cord-010092-uftc8inx 199 1 The the DT cord-010092-uftc8inx 199 2 blood blood NN cord-010092-uftc8inx 199 3 donors donor NNS cord-010092-uftc8inx 199 4 were be VBD cord-010092-uftc8inx 199 5 usually usually RB cord-010092-uftc8inx 199 6 willing willing JJ cord-010092-uftc8inx 199 7 to to TO cord-010092-uftc8inx 199 8 contribute contribute VB cord-010092-uftc8inx 199 9 to to IN cord-010092-uftc8inx 199 10 research research NN cord-010092-uftc8inx 199 11 for for IN cord-010092-uftc8inx 199 12 the the DT cord-010092-uftc8inx 199 13 public public JJ cord-010092-uftc8inx 199 14 benefit benefit NN cord-010092-uftc8inx 199 15 , , , cord-010092-uftc8inx 199 16 because because IN cord-010092-uftc8inx 199 17 they -PRON- PRP cord-010092-uftc8inx 199 18 saw see VBD cord-010092-uftc8inx 199 19 great great JJ cord-010092-uftc8inx 199 20 potential potential NN cord-010092-uftc8inx 199 21 in in IN cord-010092-uftc8inx 199 22 science science NN cord-010092-uftc8inx 199 23 to to TO cord-010092-uftc8inx 199 24 create create VB cord-010092-uftc8inx 199 25 solutions solution NNS cord-010092-uftc8inx 199 26 to to TO cord-010092-uftc8inx 199 27 help help VB cord-010092-uftc8inx 199 28 patients patient NNS cord-010092-uftc8inx 199 29 in in IN cord-010092-uftc8inx 199 30 the the DT cord-010092-uftc8inx 199 31 future future NN cord-010092-uftc8inx 199 32 . . . cord-010092-uftc8inx 200 1 However however RB cord-010092-uftc8inx 200 2 , , , cord-010092-uftc8inx 200 3 based base VBN cord-010092-uftc8inx 200 4 on on IN cord-010092-uftc8inx 200 5 our -PRON- PRP$ cord-010092-uftc8inx 200 6 interview interview NN cord-010092-uftc8inx 200 7 data datum NNS cord-010092-uftc8inx 200 8 and and CC cord-010092-uftc8inx 200 9 previous previous JJ cord-010092-uftc8inx 200 10 research research NN cord-010092-uftc8inx 200 11 , , , cord-010092-uftc8inx 200 12 we -PRON- PRP cord-010092-uftc8inx 200 13 suggest suggest VBP cord-010092-uftc8inx 200 14 that that IN cord-010092-uftc8inx 200 15 the the DT cord-010092-uftc8inx 200 16 analogy analogy NN cord-010092-uftc8inx 200 17 between between IN cord-010092-uftc8inx 200 18 gift gift NN cord-010092-uftc8inx 200 19 of of IN cord-010092-uftc8inx 200 20 life life NN cord-010092-uftc8inx 200 21 and and CC cord-010092-uftc8inx 200 22 donation donation NN cord-010092-uftc8inx 200 23 for for IN cord-010092-uftc8inx 200 24 research research NN cord-010092-uftc8inx 200 25 did do VBD cord-010092-uftc8inx 200 26 not not RB cord-010092-uftc8inx 200 27 work work VB cord-010092-uftc8inx 200 28 all all PDT cord-010092-uftc8inx 200 29 the the DT cord-010092-uftc8inx 200 30 way way NN cord-010092-uftc8inx 200 31 . . . cord-010092-uftc8inx 201 1 The the DT cord-010092-uftc8inx 201 2 metaphor metaphor NN cord-010092-uftc8inx 201 3 fails fail VBZ cord-010092-uftc8inx 201 4 to to TO cord-010092-uftc8inx 201 5 address address VB cord-010092-uftc8inx 201 6 donors donor NNS cord-010092-uftc8inx 201 7 ' ' POS cord-010092-uftc8inx 201 8 questions question NNS cord-010092-uftc8inx 201 9 on on IN cord-010092-uftc8inx 201 10 new new JJ cord-010092-uftc8inx 201 11 types type NNS cord-010092-uftc8inx 201 12 of of IN cord-010092-uftc8inx 201 13 relationships relationship NNS cord-010092-uftc8inx 201 14 , , , cord-010092-uftc8inx 201 15 interests interest NNS cord-010092-uftc8inx 201 16 and and CC cord-010092-uftc8inx 201 17 risks risk NNS cord-010092-uftc8inx 201 18 related relate VBN cord-010092-uftc8inx 201 19 to to IN cord-010092-uftc8inx 201 20 the the DT cord-010092-uftc8inx 201 21 use use NN cord-010092-uftc8inx 201 22 of of IN cord-010092-uftc8inx 201 23 personal personal JJ cord-010092-uftc8inx 201 24 data datum NNS cord-010092-uftc8inx 201 25 for for IN cord-010092-uftc8inx 201 26 research research NN cord-010092-uftc8inx 201 27 . . . cord-010092-uftc8inx 202 1 Left leave VBN cord-010092-uftc8inx 202 2 unanswered unanswered JJ cord-010092-uftc8inx 202 3 these these DT cord-010092-uftc8inx 202 4 could could MD cord-010092-uftc8inx 202 5 discourage discourage VB cord-010092-uftc8inx 202 6 donating donate VBG cord-010092-uftc8inx 202 7 for for IN cord-010092-uftc8inx 202 8 research research NN cord-010092-uftc8inx 202 9 . . . cord-010092-uftc8inx 203 1 Hence hence RB cord-010092-uftc8inx 203 2 , , , cord-010092-uftc8inx 203 3 we -PRON- PRP cord-010092-uftc8inx 203 4 argue argue VBP cord-010092-uftc8inx 203 5 that that IN cord-010092-uftc8inx 203 6 the the DT cord-010092-uftc8inx 203 7 gift gift NN cord-010092-uftc8inx 203 8 of of IN cord-010092-uftc8inx 203 9 life life NN cord-010092-uftc8inx 203 10 metaphor metaphor NN cord-010092-uftc8inx 203 11 is be VBZ cord-010092-uftc8inx 203 12 not not RB cord-010092-uftc8inx 203 13 applicable applicable JJ cord-010092-uftc8inx 203 14 to to IN cord-010092-uftc8inx 203 15 donor donor NN cord-010092-uftc8inx 203 16 recruitment recruitment NN cord-010092-uftc8inx 203 17 at at IN cord-010092-uftc8inx 203 18 the the DT cord-010092-uftc8inx 203 19 research research NN cord-010092-uftc8inx 203 20 context context NN cord-010092-uftc8inx 203 21 . . . cord-010092-uftc8inx 204 1 In in IN cord-010092-uftc8inx 204 2 this this DT cord-010092-uftc8inx 204 3 presentation presentation NN cord-010092-uftc8inx 204 4 we -PRON- PRP cord-010092-uftc8inx 204 5 wish wish VBP cord-010092-uftc8inx 204 6 to to TO cord-010092-uftc8inx 204 7 look look VB cord-010092-uftc8inx 204 8 for for IN cord-010092-uftc8inx 204 9 a a DT cord-010092-uftc8inx 204 10 better well JJR cord-010092-uftc8inx 204 11 metaphor metaphor NN cord-010092-uftc8inx 204 12 for for IN cord-010092-uftc8inx 204 13 donation donation NN cord-010092-uftc8inx 204 14 for for IN cord-010092-uftc8inx 204 15 research research NN cord-010092-uftc8inx 204 16 that that WDT cord-010092-uftc8inx 204 17 blood blood NN cord-010092-uftc8inx 204 18 services service NNS cord-010092-uftc8inx 204 19 collecting collect VBG cord-010092-uftc8inx 204 20 research research NN cord-010092-uftc8inx 204 21 data datum NNS cord-010092-uftc8inx 204 22 could could MD cord-010092-uftc8inx 204 23 apply apply VB cord-010092-uftc8inx 204 24 . . . cord-010092-uftc8inx 205 1 Academy Academy NNP cord-010092-uftc8inx 205 2 Day Day NNP cord-010092-uftc8inx 205 3 : : : cord-010092-uftc8inx 205 4 Transfusion transfusion NN cord-010092-uftc8inx 205 5 Challenges challenge NNS cord-010092-uftc8inx 205 6 in in IN cord-010092-uftc8inx 205 7 Patients patient NNS cord-010092-uftc8inx 205 8 with with IN cord-010092-uftc8inx 205 9 Sickle Sickle NNP cord-010092-uftc8inx 205 10 Cell Cell NNP cord-010092-uftc8inx 205 11 Disease Disease NNP cord-010092-uftc8inx 206 1 2A-02 2a-02 LS cord-010092-uftc8inx 206 2 - - HYPH cord-010092-uftc8inx 206 3 01 01 CD cord-010092-uftc8inx 206 4 IMMUNOHAEMATOLOGICAL IMMUNOHAEMATOLOGICAL NNP cord-010092-uftc8inx 206 5 FEATURES features NN cord-010092-uftc8inx 206 6 OF of IN cord-010092-uftc8inx 206 7 PATIENTS patient NNS cord-010092-uftc8inx 206 8 WITH with IN cord-010092-uftc8inx 206 9 SICKLE sickle NN cord-010092-uftc8inx 206 10 CELL cell NN cord-010092-uftc8inx 206 11 DISEASE disease NN cord-010092-uftc8inx 206 12 ( ( -LRB- cord-010092-uftc8inx 206 13 LFA LFA NNP cord-010092-uftc8inx 206 14 ) ) -RRB- cord-010092-uftc8inx 206 15 should should MD cord-010092-uftc8inx 206 16 be be VB cord-010092-uftc8inx 206 17 considered consider VBN cord-010092-uftc8inx 206 18 as as IN cord-010092-uftc8inx 206 19 polymorphic polymorphic JJ cord-010092-uftc8inx 206 20 antigens antigen NNS cord-010092-uftc8inx 206 21 in in IN cord-010092-uftc8inx 206 22 the the DT cord-010092-uftc8inx 206 23 African african JJ cord-010092-uftc8inx 206 24 population population NN cord-010092-uftc8inx 206 25 and and CC cord-010092-uftc8inx 206 26 these these DT cord-010092-uftc8inx 206 27 LFA LFA NNP cord-010092-uftc8inx 206 28 are be VBP cord-010092-uftc8inx 206 29 not not RB cord-010092-uftc8inx 206 30 present present JJ cord-010092-uftc8inx 206 31 in in IN cord-010092-uftc8inx 206 32 most most JJS cord-010092-uftc8inx 206 33 commercial commercial JJ cord-010092-uftc8inx 206 34 panels panel NNS cord-010092-uftc8inx 206 35 . . . cord-010092-uftc8inx 207 1 The the DT cord-010092-uftc8inx 207 2 situation situation NN cord-010092-uftc8inx 207 3 is be VBZ cord-010092-uftc8inx 207 4 even even RB cord-010092-uftc8inx 207 5 more more RBR cord-010092-uftc8inx 207 6 complicated complicated JJ cord-010092-uftc8inx 207 7 when when WRB cord-010092-uftc8inx 207 8 recipients recipient NNS cord-010092-uftc8inx 207 9 lack lack VBP cord-010092-uftc8inx 207 10 high high JJ cord-010092-uftc8inx 207 11 - - HYPH cord-010092-uftc8inx 207 12 frequency frequency NN cord-010092-uftc8inx 207 13 antigens antigen NNS cord-010092-uftc8inx 207 14 , , , cord-010092-uftc8inx 207 15 the the DT cord-010092-uftc8inx 207 16 most most RBS cord-010092-uftc8inx 207 17 common common JJ cord-010092-uftc8inx 207 18 ones one NNS cord-010092-uftc8inx 207 19 being be VBG cord-010092-uftc8inx 207 20 Hr- Hr- NNP cord-010092-uftc8inx 207 21 , , , cord-010092-uftc8inx 207 22 Hr Hr NNP cord-010092-uftc8inx 207 23 B B NNP cord-010092-uftc8inx 207 24 - - : cord-010092-uftc8inx 207 25 , , , cord-010092-uftc8inx 207 26 Sec- Sec- NNP cord-010092-uftc8inx 207 27 , , , cord-010092-uftc8inx 207 28 U U NNP cord-010092-uftc8inx 207 29 neg neg NN cord-010092-uftc8inx 207 30 , , , cord-010092-uftc8inx 207 31 U+ u+ JJ cord-010092-uftc8inx 207 32 var var NN cord-010092-uftc8inx 207 33 , , , cord-010092-uftc8inx 207 34 Js(b- Js(b- NNP cord-010092-uftc8inx 207 35 ) ) -RRB- cord-010092-uftc8inx 207 36 , , , cord-010092-uftc8inx 207 37 ( ( -LRB- cord-010092-uftc8inx 207 38 Hy- Hy- NNP cord-010092-uftc8inx 207 39 ) ) -RRB- cord-010092-uftc8inx 207 40 , , , cord-010092-uftc8inx 207 41 and and CC cord-010092-uftc8inx 207 42 Jo(a- jo(a- CD cord-010092-uftc8inx 207 43 ) ) -RRB- cord-010092-uftc8inx 207 44 . . . cord-010092-uftc8inx 208 1 Finally finally RB cord-010092-uftc8inx 208 2 , , , cord-010092-uftc8inx 208 3 there there EX cord-010092-uftc8inx 208 4 is be VBZ cord-010092-uftc8inx 208 5 a a DT cord-010092-uftc8inx 208 6 high high JJ cord-010092-uftc8inx 208 7 Rh Rh NNP cord-010092-uftc8inx 208 8 diversity diversity NN cord-010092-uftc8inx 208 9 among among IN cord-010092-uftc8inx 208 10 people people NNS cord-010092-uftc8inx 208 11 of of IN cord-010092-uftc8inx 208 12 African african JJ cord-010092-uftc8inx 208 13 descent descent NN cord-010092-uftc8inx 208 14 . . . cord-010092-uftc8inx 209 1 Because because IN cord-010092-uftc8inx 209 2 they -PRON- PRP cord-010092-uftc8inx 209 3 harbor harbor VBP cord-010092-uftc8inx 209 4 variant variant NN cord-010092-uftc8inx 209 5 alleles allele NNS cord-010092-uftc8inx 209 6 and/or and/or CC cord-010092-uftc8inx 209 7 partial partial JJ cord-010092-uftc8inx 209 8 RH RH NNP cord-010092-uftc8inx 209 9 antigens antigen NNS cord-010092-uftc8inx 209 10 , , , cord-010092-uftc8inx 209 11 they -PRON- PRP cord-010092-uftc8inx 209 12 are be VBP cord-010092-uftc8inx 209 13 at at IN cord-010092-uftc8inx 209 14 risk risk NN cord-010092-uftc8inx 209 15 of of IN cord-010092-uftc8inx 209 16 developing develop VBG cord-010092-uftc8inx 209 17 alloantibodies alloantibody NNS cord-010092-uftc8inx 209 18 . . . cord-010092-uftc8inx 210 1 In in IN cord-010092-uftc8inx 210 2 this this DT cord-010092-uftc8inx 210 3 setting setting NN cord-010092-uftc8inx 210 4 , , , cord-010092-uftc8inx 210 5 screening screening NN cord-010092-uftc8inx 210 6 for for IN cord-010092-uftc8inx 210 7 partial partial JJ cord-010092-uftc8inx 210 8 RH RH NNP cord-010092-uftc8inx 210 9 antigens antigen NNS cord-010092-uftc8inx 210 10 makes make VBZ cord-010092-uftc8inx 210 11 sense sense NN cord-010092-uftc8inx 210 12 . . . cord-010092-uftc8inx 211 1 The the DT cord-010092-uftc8inx 211 2 figures figure NNS cord-010092-uftc8inx 211 3 illustrating illustrate VBG cord-010092-uftc8inx 211 4 this this DT cord-010092-uftc8inx 211 5 diversity diversity NN cord-010092-uftc8inx 211 6 vary vary VBP cord-010092-uftc8inx 211 7 with with IN cord-010092-uftc8inx 211 8 the the DT cord-010092-uftc8inx 211 9 approach approach NN cord-010092-uftc8inx 211 10 used use VBN cord-010092-uftc8inx 211 11 . . . cord-010092-uftc8inx 212 1 One one CD cord-010092-uftc8inx 212 2 of of IN cord-010092-uftc8inx 212 3 them -PRON- PRP cord-010092-uftc8inx 212 4 is be VBZ cord-010092-uftc8inx 212 5 to to TO cord-010092-uftc8inx 212 6 take take VB cord-010092-uftc8inx 212 7 into into IN cord-010092-uftc8inx 212 8 consideration consideration NN cord-010092-uftc8inx 212 9 RHD RHD NNP cord-010092-uftc8inx 212 10 or or CC cord-010092-uftc8inx 212 11 RHCE*ce rhce*ce JJ cord-010092-uftc8inx 212 12 variant variant JJ cord-010092-uftc8inx 212 13 alleles allele NNS cord-010092-uftc8inx 212 14 . . . cord-010092-uftc8inx 213 1 In in IN cord-010092-uftc8inx 213 2 several several JJ cord-010092-uftc8inx 213 3 American american JJ cord-010092-uftc8inx 213 4 studies study NNS cord-010092-uftc8inx 213 5 , , , cord-010092-uftc8inx 213 6 their -PRON- PRP$ cord-010092-uftc8inx 213 7 prevalence prevalence NN cord-010092-uftc8inx 213 8 was be VBD cord-010092-uftc8inx 213 9 estimated estimate VBN cord-010092-uftc8inx 213 10 to to TO cord-010092-uftc8inx 213 11 be be VB cord-010092-uftc8inx 213 12 29 29 CD cord-010092-uftc8inx 213 13 - - SYM cord-010092-uftc8inx 213 14 36 36 CD cord-010092-uftc8inx 213 15 % % NN cord-010092-uftc8inx 213 16 and and CC cord-010092-uftc8inx 213 17 53 53 CD cord-010092-uftc8inx 213 18 - - SYM cord-010092-uftc8inx 213 19 72 72 CD cord-010092-uftc8inx 213 20 % % NN cord-010092-uftc8inx 213 21 , , , cord-010092-uftc8inx 213 22 respectively respectively RB cord-010092-uftc8inx 213 23 . . . cord-010092-uftc8inx 214 1 Other other JJ cord-010092-uftc8inx 214 2 teams team NNS cord-010092-uftc8inx 214 3 take take VBP cord-010092-uftc8inx 214 4 into into IN cord-010092-uftc8inx 214 5 consideration consideration NN cord-010092-uftc8inx 214 6 D d NN cord-010092-uftc8inx 214 7 , , , cord-010092-uftc8inx 214 8 C c NN cord-010092-uftc8inx 214 9 and and CC cord-010092-uftc8inx 214 10 e e LS cord-010092-uftc8inx 214 11 partial partial JJ cord-010092-uftc8inx 214 12 antigens antigen NNS cord-010092-uftc8inx 214 13 . . . cord-010092-uftc8inx 215 1 Their -PRON- PRP$ cord-010092-uftc8inx 215 2 prevalence prevalence NN cord-010092-uftc8inx 215 3 was be VBD cord-010092-uftc8inx 215 4 estimated estimate VBN cord-010092-uftc8inx 215 5 to to TO cord-010092-uftc8inx 215 6 be be VB cord-010092-uftc8inx 215 7 8.4 8.4 CD cord-010092-uftc8inx 215 8 - - SYM cord-010092-uftc8inx 215 9 14 14 CD cord-010092-uftc8inx 215 10 % % NN cord-010092-uftc8inx 215 11 , , , cord-010092-uftc8inx 215 12 12.5 12.5 CD cord-010092-uftc8inx 215 13 - - SYM cord-010092-uftc8inx 215 14 27.7 27.7 CD cord-010092-uftc8inx 215 15 % % NN cord-010092-uftc8inx 215 16 , , , cord-010092-uftc8inx 215 17 3.3 3.3 CD cord-010092-uftc8inx 215 18 - - SYM cord-010092-uftc8inx 215 19 3.5 3.5 CD cord-010092-uftc8inx 215 20 % % NN cord-010092-uftc8inx 215 21 , , , cord-010092-uftc8inx 215 22 respectively respectively RB cord-010092-uftc8inx 215 23 , , , cord-010092-uftc8inx 215 24 and and CC cord-010092-uftc8inx 215 25 the the DT cord-010092-uftc8inx 215 26 alloimmunization alloimmunization NN cord-010092-uftc8inx 215 27 rates rate NNS cord-010092-uftc8inx 215 28 were be VBD cord-010092-uftc8inx 215 29 17.6 17.6 CD cord-010092-uftc8inx 215 30 % % NN cord-010092-uftc8inx 215 31 , , , cord-010092-uftc8inx 215 32 14.3 14.3 CD cord-010092-uftc8inx 215 33 - - SYM cord-010092-uftc8inx 215 34 30 30 CD cord-010092-uftc8inx 215 35 % % NN cord-010092-uftc8inx 215 36 , , , cord-010092-uftc8inx 215 37 7.1 7.1 CD cord-010092-uftc8inx 215 38 % % NN cord-010092-uftc8inx 215 39 , , , cord-010092-uftc8inx 215 40 respectively respectively RB cord-010092-uftc8inx 215 41 . . . cord-010092-uftc8inx 216 1 As as IN cord-010092-uftc8inx 216 2 a a DT cord-010092-uftc8inx 216 3 result result NN cord-010092-uftc8inx 216 4 of of IN cord-010092-uftc8inx 216 5 these these DT cord-010092-uftc8inx 216 6 phenotype phenotype NN cord-010092-uftc8inx 216 7 discrepancies discrepancy NNS cord-010092-uftc8inx 216 8 , , , cord-010092-uftc8inx 216 9 SCD SCD NNP cord-010092-uftc8inx 216 10 patients patient NNS cord-010092-uftc8inx 216 11 are be VBP cord-010092-uftc8inx 216 12 more more RBR cord-010092-uftc8inx 216 13 likely likely JJ cord-010092-uftc8inx 216 14 to to TO cord-010092-uftc8inx 216 15 be be VB cord-010092-uftc8inx 216 16 alloimmunized alloimmunize VBN cord-010092-uftc8inx 216 17 . . . cord-010092-uftc8inx 217 1 An an DT cord-010092-uftc8inx 217 2 overall overall JJ cord-010092-uftc8inx 217 3 immunization immunization NN cord-010092-uftc8inx 217 4 rate rate NN cord-010092-uftc8inx 217 5 of of IN cord-010092-uftc8inx 217 6 2 2 CD cord-010092-uftc8inx 217 7 - - SYM cord-010092-uftc8inx 217 8 6 6 CD cord-010092-uftc8inx 217 9 % % NN cord-010092-uftc8inx 217 10 is be VBZ cord-010092-uftc8inx 217 11 commonly commonly RB cord-010092-uftc8inx 217 12 admitted admit VBN cord-010092-uftc8inx 217 13 in in IN cord-010092-uftc8inx 217 14 the the DT cord-010092-uftc8inx 217 15 general general JJ cord-010092-uftc8inx 217 16 population population NN cord-010092-uftc8inx 217 17 . . . cord-010092-uftc8inx 218 1 Depending depend VBG cord-010092-uftc8inx 218 2 on on IN cord-010092-uftc8inx 218 3 the the DT cord-010092-uftc8inx 218 4 unit unit NN cord-010092-uftc8inx 218 5 selection selection NN cord-010092-uftc8inx 218 6 policy policy NN cord-010092-uftc8inx 218 7 and/or and/or CC cord-010092-uftc8inx 218 8 the the DT cord-010092-uftc8inx 218 9 study study NN cord-010092-uftc8inx 218 10 design design NN cord-010092-uftc8inx 218 11 , , , cord-010092-uftc8inx 218 12 the the DT cord-010092-uftc8inx 218 13 immunization immunization NN cord-010092-uftc8inx 218 14 rate rate NN cord-010092-uftc8inx 218 15 in in IN cord-010092-uftc8inx 218 16 SCD SCD NNP cord-010092-uftc8inx 218 17 patients patient NNS cord-010092-uftc8inx 218 18 varies vary VBZ cord-010092-uftc8inx 218 19 from from IN cord-010092-uftc8inx 218 20 7 7 CD cord-010092-uftc8inx 218 21 % % NN cord-010092-uftc8inx 218 22 to to IN cord-010092-uftc8inx 218 23 76 76 CD cord-010092-uftc8inx 218 24 % % NN cord-010092-uftc8inx 218 25 , , , cord-010092-uftc8inx 218 26 the the DT cord-010092-uftc8inx 218 27 highest high JJS cord-010092-uftc8inx 218 28 figures figure NNS cord-010092-uftc8inx 218 29 being be VBG cord-010092-uftc8inx 218 30 established establish VBN cord-010092-uftc8inx 218 31 when when WRB cord-010092-uftc8inx 218 32 an an DT cord-010092-uftc8inx 218 33 ABO ABO NNP cord-010092-uftc8inx 218 34 / / SYM cord-010092-uftc8inx 218 35 RH1-only rh1-only NN cord-010092-uftc8inx 218 36 matching matching NN cord-010092-uftc8inx 218 37 policy policy NN cord-010092-uftc8inx 218 38 is be VBZ cord-010092-uftc8inx 218 39 implemented implement VBN cord-010092-uftc8inx 218 40 . . . cord-010092-uftc8inx 219 1 In in IN cord-010092-uftc8inx 219 2 a a DT cord-010092-uftc8inx 219 3 meta meta JJ cord-010092-uftc8inx 219 4 - - HYPH cord-010092-uftc8inx 219 5 analysis analysis NN cord-010092-uftc8inx 219 6 of of IN cord-010092-uftc8inx 219 7 24 24 CD cord-010092-uftc8inx 219 8 publications publication NNS cord-010092-uftc8inx 219 9 , , , cord-010092-uftc8inx 219 10 the the DT cord-010092-uftc8inx 219 11 overall overall JJ cord-010092-uftc8inx 219 12 alloimmunization alloimmunization NN cord-010092-uftc8inx 219 13 rates rate NNS cord-010092-uftc8inx 219 14 were be VBD cord-010092-uftc8inx 219 15 around around RB cord-010092-uftc8inx 219 16 20 20 CD cord-010092-uftc8inx 219 17 % % NN cord-010092-uftc8inx 219 18 . . . cord-010092-uftc8inx 220 1 Alloimmunization Alloimmunization NNP cord-010092-uftc8inx 220 2 is be VBZ cord-010092-uftc8inx 220 3 thought think VBN cord-010092-uftc8inx 220 4 to to TO cord-010092-uftc8inx 220 5 be be VB cord-010092-uftc8inx 220 6 enhanced enhance VBN cord-010092-uftc8inx 220 7 by by IN cord-010092-uftc8inx 220 8 an an DT cord-010092-uftc8inx 220 9 inflammatory inflammatory JJ cord-010092-uftc8inx 220 10 state state NN cord-010092-uftc8inx 220 11 , , , cord-010092-uftc8inx 220 12 which which WDT cord-010092-uftc8inx 220 13 is be VBZ cord-010092-uftc8inx 220 14 often often RB cord-010092-uftc8inx 220 15 present present JJ cord-010092-uftc8inx 220 16 in in IN cord-010092-uftc8inx 220 17 SCD SCD NNP cord-010092-uftc8inx 220 18 patients patient NNS cord-010092-uftc8inx 220 19 . . . cord-010092-uftc8inx 221 1 They -PRON- PRP cord-010092-uftc8inx 221 2 are be VBP cord-010092-uftc8inx 221 3 more more RBR cord-010092-uftc8inx 221 4 prone prone JJ cord-010092-uftc8inx 221 5 to to TO cord-010092-uftc8inx 221 6 develop develop VB cord-010092-uftc8inx 221 7 a a DT cord-010092-uftc8inx 221 8 new new JJ cord-010092-uftc8inx 221 9 alloantibody alloantibody NN cord-010092-uftc8inx 221 10 . . . cord-010092-uftc8inx 222 1 Using use VBG cord-010092-uftc8inx 222 2 a a DT cord-010092-uftc8inx 222 3 stochastic stochastic JJ cord-010092-uftc8inx 222 4 modeling modeling NN cord-010092-uftc8inx 222 5 of of IN cord-010092-uftc8inx 222 6 alloimmunization alloimmunization NN cord-010092-uftc8inx 222 7 , , , cord-010092-uftc8inx 222 8 they -PRON- PRP cord-010092-uftc8inx 222 9 have have VBP cord-010092-uftc8inx 222 10 a a DT cord-010092-uftc8inx 222 11 61 61 CD cord-010092-uftc8inx 222 12 % % NN cord-010092-uftc8inx 222 13 increased increase VBN cord-010092-uftc8inx 222 14 risk risk NN cord-010092-uftc8inx 222 15 of of IN cord-010092-uftc8inx 222 16 producing produce VBG cord-010092-uftc8inx 222 17 additional additional JJ cord-010092-uftc8inx 222 18 antibodies antibody NNS cord-010092-uftc8inx 222 19 versus versus IN cord-010092-uftc8inx 222 20 30 30 CD cord-010092-uftc8inx 222 21 % % NN cord-010092-uftc8inx 222 22 in in IN cord-010092-uftc8inx 222 23 the the DT cord-010092-uftc8inx 222 24 general general JJ cord-010092-uftc8inx 222 25 population population NN cord-010092-uftc8inx 222 26 . . . cord-010092-uftc8inx 223 1 Autoantibodies autoantibody NNS cord-010092-uftc8inx 223 2 have have VBP cord-010092-uftc8inx 223 3 been be VBN cord-010092-uftc8inx 223 4 identified identify VBN cord-010092-uftc8inx 223 5 as as IN cord-010092-uftc8inx 223 6 a a DT cord-010092-uftc8inx 223 7 risk risk NN cord-010092-uftc8inx 223 8 factor factor NN cord-010092-uftc8inx 223 9 of of IN cord-010092-uftc8inx 223 10 alloimmunization alloimmunization NN cord-010092-uftc8inx 223 11 . . . cord-010092-uftc8inx 224 1 As as IN cord-010092-uftc8inx 224 2 a a DT cord-010092-uftc8inx 224 3 result result NN cord-010092-uftc8inx 224 4 , , , cord-010092-uftc8inx 224 5 SCD SCD NNP cord-010092-uftc8inx 224 6 patients patient NNS cord-010092-uftc8inx 224 7 often often RB cord-010092-uftc8inx 224 8 have have VBP cord-010092-uftc8inx 224 9 complex complex JJ cord-010092-uftc8inx 224 10 mixtures mixture NNS cord-010092-uftc8inx 224 11 of of IN cord-010092-uftc8inx 224 12 allo allo NN cord-010092-uftc8inx 224 13 and and CC cord-010092-uftc8inx 224 14 autoantibodies autoantibody NNS cord-010092-uftc8inx 224 15 . . . cord-010092-uftc8inx 225 1 RH RH NNP cord-010092-uftc8inx 225 2 antibodies antibody NNS cord-010092-uftc8inx 225 3 and and CC cord-010092-uftc8inx 225 4 those those DT cord-010092-uftc8inx 225 5 considered consider VBN cord-010092-uftc8inx 225 6 as as IN cord-010092-uftc8inx 225 7 irregular irregular JJ cord-010092-uftc8inx 225 8 natural natural JJ cord-010092-uftc8inx 225 9 antibodies antibody NNS cord-010092-uftc8inx 225 10 are be VBP cord-010092-uftc8inx 225 11 present present JJ cord-010092-uftc8inx 225 12 in in IN cord-010092-uftc8inx 225 13 a a DT cord-010092-uftc8inx 225 14 significant significant JJ cord-010092-uftc8inx 225 15 proportion proportion NN cord-010092-uftc8inx 225 16 . . . cord-010092-uftc8inx 226 1 Another another DT cord-010092-uftc8inx 226 2 characteristic characteristic NN cord-010092-uftc8inx 226 3 of of IN cord-010092-uftc8inx 226 4 the the DT cord-010092-uftc8inx 226 5 antibodies antibody NNS cord-010092-uftc8inx 226 6 in in IN cord-010092-uftc8inx 226 7 SCD SCD NNP cord-010092-uftc8inx 226 8 patients patient NNS cord-010092-uftc8inx 226 9 is be VBZ cord-010092-uftc8inx 226 10 their -PRON- PRP$ cord-010092-uftc8inx 226 11 evanescence evanescence NN cord-010092-uftc8inx 226 12 ; ; : cord-010092-uftc8inx 226 13 up up IN cord-010092-uftc8inx 226 14 to to TO cord-010092-uftc8inx 226 15 70 70 CD cord-010092-uftc8inx 226 16 % % NN cord-010092-uftc8inx 226 17 of of IN cord-010092-uftc8inx 226 18 alloantibodies alloantibody NNS cord-010092-uftc8inx 226 19 become become VBN cord-010092-uftc8inx 226 20 undetectable undetectable JJ cord-010092-uftc8inx 226 21 within within IN cord-010092-uftc8inx 226 22 a a DT cord-010092-uftc8inx 226 23 few few JJ cord-010092-uftc8inx 226 24 years year NNS cord-010092-uftc8inx 226 25 of of IN cord-010092-uftc8inx 226 26 their -PRON- PRP$ cord-010092-uftc8inx 226 27 initial initial JJ cord-010092-uftc8inx 226 28 development development NN cord-010092-uftc8inx 226 29 . . . cord-010092-uftc8inx 227 1 Relatedly relatedly RB cord-010092-uftc8inx 227 2 , , , cord-010092-uftc8inx 227 3 about about RB cord-010092-uftc8inx 227 4 a a DT cord-010092-uftc8inx 227 5 third third NN cord-010092-uftc8inx 227 6 of of IN cord-010092-uftc8inx 227 7 DHTRs dhtr NNS cord-010092-uftc8inx 227 8 are be VBP cord-010092-uftc8inx 227 9 reported report VBN cord-010092-uftc8inx 227 10 to to TO cord-010092-uftc8inx 227 11 happen happen VB cord-010092-uftc8inx 227 12 in in IN cord-010092-uftc8inx 227 13 patients patient NNS cord-010092-uftc8inx 227 14 with with IN cord-010092-uftc8inx 227 15 no no DT cord-010092-uftc8inx 227 16 previous previous JJ cord-010092-uftc8inx 227 17 history history NN cord-010092-uftc8inx 227 18 of of IN cord-010092-uftc8inx 227 19 immunization immunization NN cord-010092-uftc8inx 227 20 . . . cord-010092-uftc8inx 228 1 In in IN cord-010092-uftc8inx 228 2 addition addition NN cord-010092-uftc8inx 228 3 , , , cord-010092-uftc8inx 228 4 a a DT cord-010092-uftc8inx 228 5 third third NN cord-010092-uftc8inx 228 6 of of IN cord-010092-uftc8inx 228 7 patients patient NNS cord-010092-uftc8inx 228 8 will will MD cord-010092-uftc8inx 228 9 not not RB cord-010092-uftc8inx 228 10 develop develop VB cord-010092-uftc8inx 228 11 an an DT cord-010092-uftc8inx 228 12 antibody antibody NN cord-010092-uftc8inx 228 13 after after IN cord-010092-uftc8inx 228 14 a a DT cord-010092-uftc8inx 228 15 DHTR dhtr NN cord-010092-uftc8inx 228 16 . . . cord-010092-uftc8inx 229 1 Identifying identify VBG cord-010092-uftc8inx 229 2 patients patient NNS cord-010092-uftc8inx 229 3 at at IN cord-010092-uftc8inx 229 4 risk risk NN cord-010092-uftc8inx 229 5 of of IN cord-010092-uftc8inx 229 6 developing develop VBG cord-010092-uftc8inx 229 7 a a DT cord-010092-uftc8inx 229 8 DHTR DHTR NNP cord-010092-uftc8inx 229 9 is be VBZ cord-010092-uftc8inx 229 10 key key JJ cord-010092-uftc8inx 229 11 to to IN cord-010092-uftc8inx 229 12 managing manage VBG cord-010092-uftc8inx 229 13 them -PRON- PRP cord-010092-uftc8inx 229 14 properly properly RB cord-010092-uftc8inx 229 15 . . . cord-010092-uftc8inx 230 1 Alloimmunization Alloimmunization NNP cord-010092-uftc8inx 230 2 is be VBZ cord-010092-uftc8inx 230 3 a a DT cord-010092-uftc8inx 230 4 serious serious JJ cord-010092-uftc8inx 230 5 risk risk NN cord-010092-uftc8inx 230 6 of of IN cord-010092-uftc8inx 230 7 red red JJ cord-010092-uftc8inx 230 8 blood blood NN cord-010092-uftc8inx 230 9 cell cell NN cord-010092-uftc8inx 230 10 transfusion transfusion NN cord-010092-uftc8inx 230 11 in in IN cord-010092-uftc8inx 230 12 patients patient NNS cord-010092-uftc8inx 230 13 with with IN cord-010092-uftc8inx 230 14 sickle sickle NN cord-010092-uftc8inx 230 15 cell cell NN cord-010092-uftc8inx 230 16 disease disease NN cord-010092-uftc8inx 230 17 ( ( -LRB- cord-010092-uftc8inx 230 18 SCD SCD NNP cord-010092-uftc8inx 230 19 ) ) -RRB- cord-010092-uftc8inx 230 20 and and CC cord-010092-uftc8inx 230 21 can can MD cord-010092-uftc8inx 230 22 result result VB cord-010092-uftc8inx 230 23 in in IN cord-010092-uftc8inx 230 24 severe severe JJ cord-010092-uftc8inx 230 25 ( ( -LRB- cord-010092-uftc8inx 230 26 delayed delayed JJ cord-010092-uftc8inx 230 27 ) ) -RRB- cord-010092-uftc8inx 230 28 haemolytic haemolytic JJ cord-010092-uftc8inx 230 29 transfusion transfusion NN cord-010092-uftc8inx 230 30 reactions reaction NNS cord-010092-uftc8inx 230 31 , , , cord-010092-uftc8inx 230 32 exacerbation exacerbation NN cord-010092-uftc8inx 230 33 of of IN cord-010092-uftc8inx 230 34 clinical clinical JJ cord-010092-uftc8inx 230 35 symptoms symptom NNS cord-010092-uftc8inx 230 36 and and CC cord-010092-uftc8inx 230 37 life life NN cord-010092-uftc8inx 230 38 - - HYPH cord-010092-uftc8inx 230 39 threatening threaten VBG cord-010092-uftc8inx 230 40 hyperhaemolysis hyperhaemolysis NN cord-010092-uftc8inx 230 41 . . . cord-010092-uftc8inx 231 1 Once once RB cord-010092-uftc8inx 231 2 alloimmunized alloimmunize VBN cord-010092-uftc8inx 231 3 , , , cord-010092-uftc8inx 231 4 the the DT cord-010092-uftc8inx 231 5 presence presence NN cord-010092-uftc8inx 231 6 of of IN cord-010092-uftc8inx 231 7 alloantibodies alloantibody NNS cord-010092-uftc8inx 231 8 in in IN cord-010092-uftc8inx 231 9 the the DT cord-010092-uftc8inx 231 10 patients patient NNS cord-010092-uftc8inx 231 11 ' ' POS cord-010092-uftc8inx 231 12 blood blood NN cord-010092-uftc8inx 231 13 further further RB cord-010092-uftc8inx 231 14 complicates complicate VBZ cord-010092-uftc8inx 231 15 pretransfusion pretransfusion NN cord-010092-uftc8inx 231 16 testing testing NN cord-010092-uftc8inx 231 17 and and CC cord-010092-uftc8inx 231 18 hampers hamper VBZ cord-010092-uftc8inx 231 19 the the DT cord-010092-uftc8inx 231 20 selection selection NN cord-010092-uftc8inx 231 21 of of IN cord-010092-uftc8inx 231 22 compatible compatible JJ cord-010092-uftc8inx 231 23 blood blood NN cord-010092-uftc8inx 231 24 products product NNS cord-010092-uftc8inx 231 25 . . . cord-010092-uftc8inx 232 1 Numerous numerous JJ cord-010092-uftc8inx 232 2 studies study NNS cord-010092-uftc8inx 232 3 have have VBP cord-010092-uftc8inx 232 4 shown show VBN cord-010092-uftc8inx 232 5 that that IN cord-010092-uftc8inx 232 6 SCD SCD NNP cord-010092-uftc8inx 232 7 patients patient NNS cord-010092-uftc8inx 232 8 have have VBP cord-010092-uftc8inx 232 9 a a DT cord-010092-uftc8inx 232 10 relatively relatively RB cord-010092-uftc8inx 232 11 high high JJ cord-010092-uftc8inx 232 12 risk risk NN cord-010092-uftc8inx 232 13 of of IN cord-010092-uftc8inx 232 14 alloimmunization alloimmunization NN cord-010092-uftc8inx 232 15 as as IN cord-010092-uftc8inx 232 16 compared compare VBN cord-010092-uftc8inx 232 17 to to IN cord-010092-uftc8inx 232 18 the the DT cord-010092-uftc8inx 232 19 ' ' `` cord-010092-uftc8inx 232 20 general general JJ cord-010092-uftc8inx 232 21 ' ' '' cord-010092-uftc8inx 232 22 population population NN cord-010092-uftc8inx 232 23 . . . cord-010092-uftc8inx 233 1 This this DT cord-010092-uftc8inx 233 2 is be VBZ cord-010092-uftc8inx 233 3 not not RB cord-010092-uftc8inx 233 4 only only RB cord-010092-uftc8inx 233 5 explained explain VBN cord-010092-uftc8inx 233 6 by by IN cord-010092-uftc8inx 233 7 the the DT cord-010092-uftc8inx 233 8 large large JJ cord-010092-uftc8inx 233 9 number number NN cord-010092-uftc8inx 233 10 of of IN cord-010092-uftc8inx 233 11 transfusions transfusion NNS cord-010092-uftc8inx 233 12 given give VBN cord-010092-uftc8inx 233 13 but but CC cord-010092-uftc8inx 233 14 also also RB cord-010092-uftc8inx 233 15 by by IN cord-010092-uftc8inx 233 16 the the DT cord-010092-uftc8inx 233 17 increased increase VBN cord-010092-uftc8inx 233 18 exposure exposure NN cord-010092-uftc8inx 233 19 to to IN cord-010092-uftc8inx 233 20 foreign foreign JJ cord-010092-uftc8inx 233 21 antigens antigen NNS cord-010092-uftc8inx 233 22 as as IN cord-010092-uftc8inx 233 23 a a DT cord-010092-uftc8inx 233 24 result result NN cord-010092-uftc8inx 233 25 of of IN cord-010092-uftc8inx 233 26 differences difference NNS cord-010092-uftc8inx 233 27 in in IN cord-010092-uftc8inx 233 28 the the DT cord-010092-uftc8inx 233 29 antigen antigen NN cord-010092-uftc8inx 233 30 make make NN cord-010092-uftc8inx 233 31 - - HYPH cord-010092-uftc8inx 233 32 up up NN cord-010092-uftc8inx 233 33 of of IN cord-010092-uftc8inx 233 34 the the DT cord-010092-uftc8inx 233 35 SCD SCD NNP cord-010092-uftc8inx 233 36 recipients recipient NNS cord-010092-uftc8inx 233 37 and and CC cord-010092-uftc8inx 233 38 the the DT cord-010092-uftc8inx 233 39 blood blood NN cord-010092-uftc8inx 233 40 donor donor NN cord-010092-uftc8inx 233 41 population population NN cord-010092-uftc8inx 233 42 . . . cord-010092-uftc8inx 234 1 Other other JJ cord-010092-uftc8inx 234 2 factors factor NNS cord-010092-uftc8inx 234 3 involved involve VBN cord-010092-uftc8inx 234 4 in in IN cord-010092-uftc8inx 234 5 the the DT cord-010092-uftc8inx 234 6 immune immune JJ cord-010092-uftc8inx 234 7 response response NN cord-010092-uftc8inx 234 8 such such JJ cord-010092-uftc8inx 234 9 as as IN cord-010092-uftc8inx 234 10 age age NN cord-010092-uftc8inx 234 11 at at IN cord-010092-uftc8inx 234 12 first first JJ cord-010092-uftc8inx 234 13 transfusion transfusion NN cord-010092-uftc8inx 234 14 , , , cord-010092-uftc8inx 234 15 inflammatory inflammatory JJ cord-010092-uftc8inx 234 16 state state NN cord-010092-uftc8inx 234 17 , , , cord-010092-uftc8inx 234 18 HLA HLA NNP cord-010092-uftc8inx 234 19 typing typing NN cord-010092-uftc8inx 234 20 are be VBP cord-010092-uftc8inx 234 21 under under IN cord-010092-uftc8inx 234 22 investigation investigation NN cord-010092-uftc8inx 234 23 and and CC cord-010092-uftc8inx 234 24 are be VBP cord-010092-uftc8inx 234 25 starting start VBG cord-010092-uftc8inx 234 26 to to TO cord-010092-uftc8inx 234 27 unravel unravel VB cord-010092-uftc8inx 234 28 . . . cord-010092-uftc8inx 235 1 Because because IN cord-010092-uftc8inx 235 2 blood blood NN cord-010092-uftc8inx 235 3 transfusion transfusion NN cord-010092-uftc8inx 235 4 is be VBZ cord-010092-uftc8inx 235 5 still still RB cord-010092-uftc8inx 235 6 one one CD cord-010092-uftc8inx 235 7 of of IN cord-010092-uftc8inx 235 8 the the DT cord-010092-uftc8inx 235 9 main main JJ cord-010092-uftc8inx 235 10 treatment treatment NN cord-010092-uftc8inx 235 11 modalities modality NNS cord-010092-uftc8inx 235 12 for for IN cord-010092-uftc8inx 235 13 SCD SCD NNP cord-010092-uftc8inx 235 14 and and CC cord-010092-uftc8inx 235 15 some some DT cord-010092-uftc8inx 235 16 patients patient NNS cord-010092-uftc8inx 235 17 have have VBP cord-010092-uftc8inx 235 18 a a DT cord-010092-uftc8inx 235 19 life life NN cord-010092-uftc8inx 235 20 - - HYPH cord-010092-uftc8inx 235 21 long long JJ cord-010092-uftc8inx 235 22 transfusion transfusion NN cord-010092-uftc8inx 235 23 dependency dependency NN cord-010092-uftc8inx 235 24 it -PRON- PRP cord-010092-uftc8inx 235 25 is be VBZ cord-010092-uftc8inx 235 26 important important JJ cord-010092-uftc8inx 235 27 to to TO cord-010092-uftc8inx 235 28 minimize minimize VB cord-010092-uftc8inx 235 29 the the DT cord-010092-uftc8inx 235 30 alloimmunization alloimmunization NN cord-010092-uftc8inx 235 31 rate rate NN cord-010092-uftc8inx 235 32 . . . cord-010092-uftc8inx 236 1 Theoretically theoretically RB cord-010092-uftc8inx 236 2 , , , cord-010092-uftc8inx 236 3 complete complete JJ cord-010092-uftc8inx 236 4 matching matching NN cord-010092-uftc8inx 236 5 for for IN cord-010092-uftc8inx 236 6 all all DT cord-010092-uftc8inx 236 7 relevant relevant JJ cord-010092-uftc8inx 236 8 blood blood NN cord-010092-uftc8inx 236 9 group group NN cord-010092-uftc8inx 236 10 antigens antigen NNS cord-010092-uftc8inx 236 11 would would MD cord-010092-uftc8inx 236 12 prevent prevent VB cord-010092-uftc8inx 236 13 alloimmunization alloimmunization NN cord-010092-uftc8inx 236 14 . . . cord-010092-uftc8inx 237 1 This this DT cord-010092-uftc8inx 237 2 however however RB cord-010092-uftc8inx 237 3 , , , cord-010092-uftc8inx 237 4 is be VBZ cord-010092-uftc8inx 237 5 only only RB cord-010092-uftc8inx 237 6 possible possible JJ cord-010092-uftc8inx 237 7 when when WRB cord-010092-uftc8inx 237 8 all all DT cord-010092-uftc8inx 237 9 donors donor NNS cord-010092-uftc8inx 237 10 are be VBP cord-010092-uftc8inx 237 11 comprehensively comprehensively RB cord-010092-uftc8inx 237 12 . . . cord-010092-uftc8inx 238 1 Matching match VBG cord-010092-uftc8inx 238 2 strategies strategy NNS cord-010092-uftc8inx 238 3 should should MD cord-010092-uftc8inx 238 4 be be VB cord-010092-uftc8inx 238 5 developed develop VBN cord-010092-uftc8inx 238 6 to to TO cord-010092-uftc8inx 238 7 minimize minimize VB cord-010092-uftc8inx 238 8 alloimmunization alloimmunization NN cord-010092-uftc8inx 238 9 while while IN cord-010092-uftc8inx 238 10 balancing balance VBG cord-010092-uftc8inx 238 11 patients patient NNS cord-010092-uftc8inx 238 12 ' ' POS cord-010092-uftc8inx 238 13 need need VB cord-010092-uftc8inx 238 14 and and CC cord-010092-uftc8inx 238 15 donor donor NN cord-010092-uftc8inx 238 16 availability availability NN cord-010092-uftc8inx 238 17 and and CC cord-010092-uftc8inx 238 18 is be VBZ cord-010092-uftc8inx 238 19 cost cost VBN cord-010092-uftc8inx 238 20 effective effective JJ cord-010092-uftc8inx 238 21 . . . cord-010092-uftc8inx 239 1 To to TO cord-010092-uftc8inx 239 2 develop develop VB cord-010092-uftc8inx 239 3 a a DT cord-010092-uftc8inx 239 4 ( ( -LRB- cord-010092-uftc8inx 239 5 preventive preventive JJ cord-010092-uftc8inx 239 6 ) ) -RRB- cord-010092-uftc8inx 239 7 matching matching NN cord-010092-uftc8inx 239 8 strategy strategy NN cord-010092-uftc8inx 239 9 some some DT cord-010092-uftc8inx 239 10 factors factor NNS cord-010092-uftc8inx 239 11 need need VBP cord-010092-uftc8inx 239 12 to to TO cord-010092-uftc8inx 239 13 be be VB cord-010092-uftc8inx 239 14 established establish VBN cord-010092-uftc8inx 239 15 ; ; : cord-010092-uftc8inx 239 16 1 1 LS cord-010092-uftc8inx 239 17 ) ) -RRB- cord-010092-uftc8inx 239 18 which which WDT cord-010092-uftc8inx 239 19 antibody antibody NN cord-010092-uftc8inx 239 20 specificities specificity NNS cord-010092-uftc8inx 239 21 are be VBP cord-010092-uftc8inx 239 22 clinically clinically RB cord-010092-uftc8inx 239 23 relevant relevant JJ cord-010092-uftc8inx 239 24 2 2 CD cord-010092-uftc8inx 239 25 ) ) -RRB- cord-010092-uftc8inx 239 26 which which WDT cord-010092-uftc8inx 239 27 antigens antigen NNS cord-010092-uftc8inx 239 28 are be VBP cord-010092-uftc8inx 239 29 most most RBS cord-010092-uftc8inx 239 30 immunogenic immunogenic JJ cord-010092-uftc8inx 239 31 3 3 CD cord-010092-uftc8inx 239 32 ) ) -RRB- cord-010092-uftc8inx 239 33 what what WP cord-010092-uftc8inx 239 34 is be VBZ cord-010092-uftc8inx 239 35 the the DT cord-010092-uftc8inx 239 36 availability availability NN cord-010092-uftc8inx 239 37 of of IN cord-010092-uftc8inx 239 38 specific specific JJ cord-010092-uftc8inx 239 39 antigen antigen NN cord-010092-uftc8inx 239 40 typings typing NNS cord-010092-uftc8inx 239 41 in in IN cord-010092-uftc8inx 239 42 the the DT cord-010092-uftc8inx 239 43 donor donor NN cord-010092-uftc8inx 239 44 population population NN cord-010092-uftc8inx 239 45 4 4 CD cord-010092-uftc8inx 239 46 ) ) -RRB- cord-010092-uftc8inx 240 1 how how WRB cord-010092-uftc8inx 240 2 should should MD cord-010092-uftc8inx 240 3 recipients recipient NNS cord-010092-uftc8inx 240 4 ( ( -LRB- cord-010092-uftc8inx 240 5 and and CC cord-010092-uftc8inx 240 6 donors donor NNS cord-010092-uftc8inx 240 7 ) ) -RRB- cord-010092-uftc8inx 240 8 be be VB cord-010092-uftc8inx 240 9 typed type VBN cord-010092-uftc8inx 240 10 , , , cord-010092-uftc8inx 240 11 phenotypically phenotypically RB cord-010092-uftc8inx 240 12 and/or and/or CC cord-010092-uftc8inx 240 13 genotypically genotypically RB cord-010092-uftc8inx 240 14 and and CC cord-010092-uftc8inx 240 15 to to TO cord-010092-uftc8inx 240 16 what what WDT cord-010092-uftc8inx 240 17 extent extent NN cord-010092-uftc8inx 240 18 . . . cord-010092-uftc8inx 241 1 The the DT cord-010092-uftc8inx 241 2 latter latter JJ cord-010092-uftc8inx 241 3 is be VBZ cord-010092-uftc8inx 241 4 especially especially RB cord-010092-uftc8inx 241 5 important important JJ cord-010092-uftc8inx 241 6 in in IN cord-010092-uftc8inx 241 7 SCD SCD NNP cord-010092-uftc8inx 241 8 patients patient NNS cord-010092-uftc8inx 241 9 since since IN cord-010092-uftc8inx 241 10 they -PRON- PRP cord-010092-uftc8inx 241 11 are be VBP cord-010092-uftc8inx 241 12 of of IN cord-010092-uftc8inx 241 13 African african JJ cord-010092-uftc8inx 241 14 descent descent NN cord-010092-uftc8inx 241 15 and and CC cord-010092-uftc8inx 241 16 the the DT cord-010092-uftc8inx 241 17 prevalence prevalence NN cord-010092-uftc8inx 241 18 of of IN cord-010092-uftc8inx 241 19 genetic genetic JJ cord-010092-uftc8inx 241 20 variations variation NNS cord-010092-uftc8inx 241 21 in in IN cord-010092-uftc8inx 241 22 this this DT cord-010092-uftc8inx 241 23 population population NN cord-010092-uftc8inx 241 24 is be VBZ cord-010092-uftc8inx 241 25 relatively relatively RB cord-010092-uftc8inx 241 26 high high JJ cord-010092-uftc8inx 241 27 . . . cord-010092-uftc8inx 242 1 RhD RhD NNP cord-010092-uftc8inx 242 2 and and CC cord-010092-uftc8inx 242 3 RhCE RhCE NNP cord-010092-uftc8inx 242 4 variants variant NNS cord-010092-uftc8inx 242 5 are be VBP cord-010092-uftc8inx 242 6 common common JJ cord-010092-uftc8inx 242 7 and and CC cord-010092-uftc8inx 242 8 can can MD cord-010092-uftc8inx 242 9 remain remain VB cord-010092-uftc8inx 242 10 undetected undetected JJ cord-010092-uftc8inx 242 11 when when WRB cord-010092-uftc8inx 242 12 serological serological JJ cord-010092-uftc8inx 242 13 typing typing NN cord-010092-uftc8inx 242 14 is be VBZ cord-010092-uftc8inx 242 15 used use VBN cord-010092-uftc8inx 242 16 but but CC cord-010092-uftc8inx 242 17 can can MD cord-010092-uftc8inx 242 18 be be VB cord-010092-uftc8inx 242 19 discovered discover VBN cord-010092-uftc8inx 242 20 with with IN cord-010092-uftc8inx 242 21 high high JJ cord-010092-uftc8inx 242 22 resolution resolution NN cord-010092-uftc8inx 242 23 molecular molecular JJ cord-010092-uftc8inx 242 24 typing typing NN cord-010092-uftc8inx 242 25 . . . cord-010092-uftc8inx 243 1 Patients patient NNS cord-010092-uftc8inx 243 2 with with IN cord-010092-uftc8inx 243 3 partial partial JJ cord-010092-uftc8inx 243 4 Rh Rh NNP cord-010092-uftc8inx 243 5 phenotypes phenotype NNS cord-010092-uftc8inx 243 6 are be VBP cord-010092-uftc8inx 243 7 at at IN cord-010092-uftc8inx 243 8 risk risk NN cord-010092-uftc8inx 243 9 for for IN cord-010092-uftc8inx 243 10 alloimmunization alloimmunization NN cord-010092-uftc8inx 243 11 . . . cord-010092-uftc8inx 244 1 Apart apart RB cord-010092-uftc8inx 244 2 from from IN cord-010092-uftc8inx 244 3 special special JJ cord-010092-uftc8inx 244 4 Rh Rh NNP cord-010092-uftc8inx 244 5 phenotypes phenotype NNS cord-010092-uftc8inx 244 6 in in IN cord-010092-uftc8inx 244 7 individuals individual NNS cord-010092-uftc8inx 244 8 from from IN cord-010092-uftc8inx 244 9 African african JJ cord-010092-uftc8inx 244 10 descent descent NN cord-010092-uftc8inx 244 11 , , , cord-010092-uftc8inx 244 12 the the DT cord-010092-uftc8inx 244 13 Fy(a Fy(a NNP cord-010092-uftc8inx 244 14 - - HYPH cord-010092-uftc8inx 244 15 b- b- NNP cord-010092-uftc8inx 244 16 ) ) -RRB- cord-010092-uftc8inx 244 17 phenotype phenotype NN cord-010092-uftc8inx 244 18 related relate VBN cord-010092-uftc8inx 244 19 to to IN cord-010092-uftc8inx 244 20 the the DT cord-010092-uftc8inx 244 21 GATA GATA NNP cord-010092-uftc8inx 244 22 - - HYPH cord-010092-uftc8inx 244 23 box box NN cord-010092-uftc8inx 244 24 mutation mutation NN cord-010092-uftc8inx 244 25 in in IN cord-010092-uftc8inx 244 26 the the DT cord-010092-uftc8inx 244 27 FYB FYB NNP cord-010092-uftc8inx 244 28 allele allele NN cord-010092-uftc8inx 244 29 and and CC cord-010092-uftc8inx 244 30 the the DT cord-010092-uftc8inx 244 31 U U NNP cord-010092-uftc8inx 244 32 - - : cord-010092-uftc8inx 244 33 or or CC cord-010092-uftc8inx 244 34 U u NN cord-010092-uftc8inx 244 35 var var NN cord-010092-uftc8inx 244 36 phenotype phenotype NN cord-010092-uftc8inx 244 37 resulting result VBG cord-010092-uftc8inx 244 38 from from IN cord-010092-uftc8inx 244 39 genetic genetic JJ cord-010092-uftc8inx 244 40 variations variation NNS cord-010092-uftc8inx 244 41 in in IN cord-010092-uftc8inx 244 42 the the DT cord-010092-uftc8inx 244 43 MNS MNS NNP cord-010092-uftc8inx 244 44 alleles allele NNS cord-010092-uftc8inx 244 45 are be VBP cord-010092-uftc8inx 244 46 also also RB cord-010092-uftc8inx 244 47 common common JJ cord-010092-uftc8inx 244 48 . . . cord-010092-uftc8inx 245 1 Several several JJ cord-010092-uftc8inx 245 2 studies study NNS cord-010092-uftc8inx 245 3 have have VBP cord-010092-uftc8inx 245 4 shown show VBN cord-010092-uftc8inx 245 5 that that IN cord-010092-uftc8inx 245 6 in in IN cord-010092-uftc8inx 245 7 SCD SCD NNP cord-010092-uftc8inx 245 8 patients patient NNS cord-010092-uftc8inx 245 9 antibodies antibody NNS cord-010092-uftc8inx 245 10 directed direct VBN cord-010092-uftc8inx 245 11 against against IN cord-010092-uftc8inx 245 12 RhD RhD NNP cord-010092-uftc8inx 245 13 , , , cord-010092-uftc8inx 245 14 RhE rhe NN cord-010092-uftc8inx 245 15 , , , cord-010092-uftc8inx 245 16 RhC rhc NN cord-010092-uftc8inx 245 17 and and CC cord-010092-uftc8inx 245 18 K K NNP cord-010092-uftc8inx 245 19 are be VBP cord-010092-uftc8inx 245 20 most most RBS cord-010092-uftc8inx 245 21 frequently frequently RB cord-010092-uftc8inx 245 22 found find VBN cord-010092-uftc8inx 245 23 when when WRB cord-010092-uftc8inx 245 24 unmatched unmatched JJ cord-010092-uftc8inx 245 25 transfusions transfusion NNS cord-010092-uftc8inx 245 26 are be VBP cord-010092-uftc8inx 245 27 given give VBN cord-010092-uftc8inx 245 28 . . . cord-010092-uftc8inx 246 1 Preventive preventive JJ cord-010092-uftc8inx 246 2 matching matching NN cord-010092-uftc8inx 246 3 for for IN cord-010092-uftc8inx 246 4 these these DT cord-010092-uftc8inx 246 5 antigens antigen NNS cord-010092-uftc8inx 246 6 has have VBZ cord-010092-uftc8inx 246 7 proven prove VBN cord-010092-uftc8inx 246 8 successful successful JJ cord-010092-uftc8inx 246 9 in in IN cord-010092-uftc8inx 246 10 reducing reduce VBG cord-010092-uftc8inx 246 11 alloimmunisation alloimmunisation NN cord-010092-uftc8inx 246 12 . . . cord-010092-uftc8inx 247 1 Extended extend VBN cord-010092-uftc8inx 247 2 matching matching NN cord-010092-uftc8inx 247 3 for for IN cord-010092-uftc8inx 247 4 all all DT cord-010092-uftc8inx 247 5 Rh Rh NNP cord-010092-uftc8inx 247 6 antigens antigen NNS cord-010092-uftc8inx 247 7 Fy(a Fy(a NNP cord-010092-uftc8inx 247 8 ) ) -RRB- cord-010092-uftc8inx 247 9 , , , cord-010092-uftc8inx 247 10 Jk(a Jk(a NNP cord-010092-uftc8inx 247 11 ) ) -RRB- cord-010092-uftc8inx 247 12 and and CC cord-010092-uftc8inx 247 13 Jk(b Jk(b NNP cord-010092-uftc8inx 247 14 ) ) -RRB- cord-010092-uftc8inx 247 15 can can MD cord-010092-uftc8inx 247 16 further further RB cord-010092-uftc8inx 247 17 decrease decrease VB cord-010092-uftc8inx 247 18 the the DT cord-010092-uftc8inx 247 19 alloimmunisation alloimmunisation NN cord-010092-uftc8inx 247 20 rate rate NN cord-010092-uftc8inx 247 21 . . . cord-010092-uftc8inx 248 1 Currently currently RB cord-010092-uftc8inx 248 2 , , , cord-010092-uftc8inx 248 3 different different JJ cord-010092-uftc8inx 248 4 countries country NNS cord-010092-uftc8inx 248 5 have have VBP cord-010092-uftc8inx 248 6 preventive preventive JJ cord-010092-uftc8inx 248 7 matching matching NN cord-010092-uftc8inx 248 8 strategies strategy NNS cord-010092-uftc8inx 248 9 in in IN cord-010092-uftc8inx 248 10 place place NN cord-010092-uftc8inx 248 11 for for IN cord-010092-uftc8inx 248 12 this this DT cord-010092-uftc8inx 248 13 vulnerable vulnerable JJ cord-010092-uftc8inx 248 14 patient patient NN cord-010092-uftc8inx 248 15 group group NN cord-010092-uftc8inx 248 16 . . . cord-010092-uftc8inx 249 1 As as IN cord-010092-uftc8inx 249 2 genotyping genotyping NN cord-010092-uftc8inx 249 3 is be VBZ cord-010092-uftc8inx 249 4 more more JJR cord-010092-uftc8inx 249 5 and and CC cord-010092-uftc8inx 249 6 more more RBR cord-010092-uftc8inx 249 7 available available JJ cord-010092-uftc8inx 249 8 and and CC cord-010092-uftc8inx 249 9 within within IN cord-010092-uftc8inx 249 10 reach reach NN cord-010092-uftc8inx 249 11 , , , cord-010092-uftc8inx 249 12 optimal optimal JJ cord-010092-uftc8inx 249 13 antigen antigen NN cord-010092-uftc8inx 249 14 typing typing NN cord-010092-uftc8inx 249 15 approaches approach NNS cord-010092-uftc8inx 249 16 for for IN cord-010092-uftc8inx 249 17 patients patient NNS cord-010092-uftc8inx 249 18 and and CC cord-010092-uftc8inx 249 19 donors donor NNS cord-010092-uftc8inx 249 20 , , , cord-010092-uftc8inx 249 21 combining combine VBG cord-010092-uftc8inx 249 22 serology serology NN cord-010092-uftc8inx 249 23 and and CC cord-010092-uftc8inx 249 24 genetics genetic NNS cord-010092-uftc8inx 249 25 are be VBP cord-010092-uftc8inx 249 26 being be VBG cord-010092-uftc8inx 249 27 developed develop VBN cord-010092-uftc8inx 249 28 . . . cord-010092-uftc8inx 250 1 In in IN cord-010092-uftc8inx 250 2 this this DT cord-010092-uftc8inx 250 3 lecture lecture NN cord-010092-uftc8inx 250 4 several several JJ cord-010092-uftc8inx 250 5 aspects aspect NNS cord-010092-uftc8inx 250 6 of of IN cord-010092-uftc8inx 250 7 antigen antigen NN cord-010092-uftc8inx 250 8 typing typing NN cord-010092-uftc8inx 250 9 approaches approach NNS cord-010092-uftc8inx 250 10 and and CC cord-010092-uftc8inx 250 11 preventive preventive JJ cord-010092-uftc8inx 250 12 matching matching NN cord-010092-uftc8inx 250 13 strategies strategy NNS cord-010092-uftc8inx 250 14 that that WDT cord-010092-uftc8inx 250 15 will will MD cord-010092-uftc8inx 250 16 most most RBS cord-010092-uftc8inx 250 17 benefit benefit VB cord-010092-uftc8inx 250 18 SCD SCD NNP cord-010092-uftc8inx 250 19 patients patient NNS cord-010092-uftc8inx 250 20 of of IN cord-010092-uftc8inx 250 21 will will MD cord-010092-uftc8inx 250 22 be be VB cord-010092-uftc8inx 250 23 discussed discuss VBN cord-010092-uftc8inx 250 24 . . . cord-010092-uftc8inx 251 1 Artificial artificial JJ cord-010092-uftc8inx 251 2 intelligence intelligence NN cord-010092-uftc8inx 251 3 has have VBZ cord-010092-uftc8inx 251 4 become become VBN cord-010092-uftc8inx 251 5 a a DT cord-010092-uftc8inx 251 6 buzzword buzzword NN cord-010092-uftc8inx 251 7 that that WDT cord-010092-uftc8inx 251 8 will will MD cord-010092-uftc8inx 251 9 appear appear VB cord-010092-uftc8inx 251 10 about about IN cord-010092-uftc8inx 251 11 anywhere anywhere RB cord-010092-uftc8inx 251 12 in in IN cord-010092-uftc8inx 251 13 the the DT cord-010092-uftc8inx 251 14 media medium NNS cord-010092-uftc8inx 251 15 . . . cord-010092-uftc8inx 252 1 We -PRON- PRP cord-010092-uftc8inx 252 2 can can MD cord-010092-uftc8inx 252 3 forget forget VB cord-010092-uftc8inx 252 4 that that IN cord-010092-uftc8inx 252 5 AI AI NNP cord-010092-uftc8inx 252 6 , , , cord-010092-uftc8inx 252 7 or or CC cord-010092-uftc8inx 252 8 the the DT cord-010092-uftc8inx 252 9 subfield subfield NN cord-010092-uftc8inx 252 10 in in IN cord-010092-uftc8inx 252 11 this this DT cord-010092-uftc8inx 252 12 computer computer NN cord-010092-uftc8inx 252 13 science science NN cord-010092-uftc8inx 252 14 field field NN cord-010092-uftc8inx 252 15 machine machine NN cord-010092-uftc8inx 252 16 learning learning NN cord-010092-uftc8inx 252 17 , , , cord-010092-uftc8inx 252 18 has have VBZ cord-010092-uftc8inx 252 19 been be VBN cord-010092-uftc8inx 252 20 around around RB cord-010092-uftc8inx 252 21 for for IN cord-010092-uftc8inx 252 22 over over IN cord-010092-uftc8inx 252 23 50 50 CD cord-010092-uftc8inx 252 24 years year NNS cord-010092-uftc8inx 252 25 . . . cord-010092-uftc8inx 253 1 Improvements improvement NNS cord-010092-uftc8inx 253 2 in in IN cord-010092-uftc8inx 253 3 computing computing NN cord-010092-uftc8inx 253 4 power power NN cord-010092-uftc8inx 253 5 , , , cord-010092-uftc8inx 253 6 abundance abundance NN cord-010092-uftc8inx 253 7 of of IN cord-010092-uftc8inx 253 8 data datum NNS cord-010092-uftc8inx 253 9 , , , cord-010092-uftc8inx 253 10 progress progress NN cord-010092-uftc8inx 253 11 in in IN cord-010092-uftc8inx 253 12 computer computer NN cord-010092-uftc8inx 253 13 science science NN cord-010092-uftc8inx 253 14 , , , cord-010092-uftc8inx 253 15 and and CC cord-010092-uftc8inx 253 16 the the DT cord-010092-uftc8inx 253 17 arrival arrival NN cord-010092-uftc8inx 253 18 of of IN cord-010092-uftc8inx 253 19 affordable affordable JJ cord-010092-uftc8inx 253 20 cloud cloud NN cord-010092-uftc8inx 253 21 solutions solution NNS cord-010092-uftc8inx 253 22 have have VBP cord-010092-uftc8inx 253 23 now now RB cord-010092-uftc8inx 253 24 brought bring VBN cord-010092-uftc8inx 253 25 it -PRON- PRP cord-010092-uftc8inx 253 26 to to IN cord-010092-uftc8inx 253 27 our -PRON- PRP$ cord-010092-uftc8inx 253 28 daily daily JJ cord-010092-uftc8inx 253 29 lives life NNS cord-010092-uftc8inx 253 30 . . . cord-010092-uftc8inx 254 1 Also also RB cord-010092-uftc8inx 254 2 in in IN cord-010092-uftc8inx 254 3 health health NN cord-010092-uftc8inx 254 4 care care NN cord-010092-uftc8inx 254 5 news news NN cord-010092-uftc8inx 254 6 about about IN cord-010092-uftc8inx 254 7 AI AI NNP cord-010092-uftc8inx 254 8 has have VBZ cord-010092-uftc8inx 254 9 become become VBN cord-010092-uftc8inx 254 10 omnipresent omnipresent JJ cord-010092-uftc8inx 254 11 . . . cord-010092-uftc8inx 255 1 And and CC cord-010092-uftc8inx 255 2 some some DT cord-010092-uftc8inx 255 3 landmark landmark JJ cord-010092-uftc8inx 255 4 papers paper NNS cord-010092-uftc8inx 255 5 have have VBP cord-010092-uftc8inx 255 6 come come VBN cord-010092-uftc8inx 255 7 out out RP cord-010092-uftc8inx 255 8 on on IN cord-010092-uftc8inx 255 9 algorithms algorithm NNS cord-010092-uftc8inx 255 10 outperforming outperform VBG cord-010092-uftc8inx 255 11 ( ( -LRB- cord-010092-uftc8inx 255 12 teams team NNS cord-010092-uftc8inx 255 13 of of IN cord-010092-uftc8inx 255 14 ) ) -RRB- cord-010092-uftc8inx 255 15 physicians physician NNS cord-010092-uftc8inx 255 16 in in IN cord-010092-uftc8inx 255 17 the the DT cord-010092-uftc8inx 255 18 diagnosis diagnosis NN cord-010092-uftc8inx 255 19 of of IN cord-010092-uftc8inx 255 20 all all DT cord-010092-uftc8inx 255 21 kinds kind NNS cord-010092-uftc8inx 255 22 of of IN cord-010092-uftc8inx 255 23 skin skin NN cord-010092-uftc8inx 255 24 disease disease NN cord-010092-uftc8inx 255 25 , , , cord-010092-uftc8inx 255 26 eye eye NN cord-010092-uftc8inx 255 27 disease disease NN cord-010092-uftc8inx 255 28 from from IN cord-010092-uftc8inx 255 29 retina retina NN cord-010092-uftc8inx 255 30 scans scan NNS cord-010092-uftc8inx 255 31 , , , cord-010092-uftc8inx 255 32 and and CC cord-010092-uftc8inx 255 33 detect detect VB cord-010092-uftc8inx 255 34 cancer cancer NN cord-010092-uftc8inx 255 35 in in IN cord-010092-uftc8inx 255 36 CT CT NNP cord-010092-uftc8inx 255 37 scans scan NNS cord-010092-uftc8inx 255 38 . . . cord-010092-uftc8inx 256 1 However however RB cord-010092-uftc8inx 256 2 , , , cord-010092-uftc8inx 256 3 little little JJ cord-010092-uftc8inx 256 4 of of IN cord-010092-uftc8inx 256 5 these these DT cord-010092-uftc8inx 256 6 solutions solution NNS cord-010092-uftc8inx 256 7 have have VBP cord-010092-uftc8inx 256 8 actually actually RB cord-010092-uftc8inx 256 9 shown show VBN cord-010092-uftc8inx 256 10 up up RP cord-010092-uftc8inx 256 11 in in IN cord-010092-uftc8inx 256 12 our -PRON- PRP$ cord-010092-uftc8inx 256 13 clinical clinical JJ cord-010092-uftc8inx 256 14 practice practice NN cord-010092-uftc8inx 256 15 yet yet RB cord-010092-uftc8inx 256 16 . . . cord-010092-uftc8inx 257 1 In in IN cord-010092-uftc8inx 257 2 anaesthesia anaesthesia NN cord-010092-uftc8inx 257 3 , , , cord-010092-uftc8inx 257 4 we -PRON- PRP cord-010092-uftc8inx 257 5 worked work VBD cord-010092-uftc8inx 257 6 with with IN cord-010092-uftc8inx 257 7 the the DT cord-010092-uftc8inx 257 8 first first JJ cord-010092-uftc8inx 257 9 algorithm algorithm NN cord-010092-uftc8inx 257 10 to to TO cord-010092-uftc8inx 257 11 come come VB cord-010092-uftc8inx 257 12 to to IN cord-010092-uftc8inx 257 13 anaesthesia anaesthesia NN cord-010092-uftc8inx 257 14 practice practice NN cord-010092-uftc8inx 257 15 ; ; : cord-010092-uftc8inx 257 16 Hypotension hypotension NN cord-010092-uftc8inx 257 17 during during IN cord-010092-uftc8inx 257 18 surgery surgery NN cord-010092-uftc8inx 257 19 is be VBZ cord-010092-uftc8inx 257 20 associated associate VBN cord-010092-uftc8inx 257 21 strongly strongly RB cord-010092-uftc8inx 257 22 with with IN cord-010092-uftc8inx 257 23 poor poor JJ cord-010092-uftc8inx 257 24 outcome outcome NN cord-010092-uftc8inx 257 25 like like IN cord-010092-uftc8inx 257 26 myocardial myocardial JJ cord-010092-uftc8inx 257 27 ischemia ischemia NN cord-010092-uftc8inx 257 28 , , , cord-010092-uftc8inx 257 29 surgical surgical JJ cord-010092-uftc8inx 257 30 complications complication NNS cord-010092-uftc8inx 257 31 , , , cord-010092-uftc8inx 257 32 renal renal JJ cord-010092-uftc8inx 257 33 failure failure NN cord-010092-uftc8inx 257 34 and and CC cord-010092-uftc8inx 257 35 even even RB cord-010092-uftc8inx 257 36 mortality mortality NN cord-010092-uftc8inx 257 37 . . . cord-010092-uftc8inx 258 1 We -PRON- PRP cord-010092-uftc8inx 258 2 worked work VBD cord-010092-uftc8inx 258 3 on on IN cord-010092-uftc8inx 258 4 a a DT cord-010092-uftc8inx 258 5 machine machine NN cord-010092-uftc8inx 258 6 - - HYPH cord-010092-uftc8inx 258 7 learning learn VBG cord-010092-uftc8inx 258 8 trained train VBN cord-010092-uftc8inx 258 9 algorithm algorithm NN cord-010092-uftc8inx 258 10 that that WDT cord-010092-uftc8inx 258 11 predicts predict VBZ cord-010092-uftc8inx 258 12 hypotensive hypotensive JJ cord-010092-uftc8inx 258 13 events event NNS cord-010092-uftc8inx 258 14 using use VBG cord-010092-uftc8inx 258 15 the the DT cord-010092-uftc8inx 258 16 arterial arterial JJ cord-010092-uftc8inx 258 17 blood blood NN cord-010092-uftc8inx 258 18 pressure pressure NN cord-010092-uftc8inx 258 19 curve curve NN cord-010092-uftc8inx 258 20 up up IN cord-010092-uftc8inx 258 21 to to TO cord-010092-uftc8inx 258 22 15 15 CD cord-010092-uftc8inx 258 23 - - SYM cord-010092-uftc8inx 258 24 30 30 CD cord-010092-uftc8inx 258 25 min min NN cord-010092-uftc8inx 258 26 before before IN cord-010092-uftc8inx 258 27 the the DT cord-010092-uftc8inx 258 28 actual actual JJ cord-010092-uftc8inx 258 29 event event NN cord-010092-uftc8inx 258 30 . . . cord-010092-uftc8inx 259 1 To to TO cord-010092-uftc8inx 259 2 get get VB cord-010092-uftc8inx 259 3 FDA FDA NNP cord-010092-uftc8inx 259 4 and and CC cord-010092-uftc8inx 259 5 CE CE NNP cord-010092-uftc8inx 259 6 approval approval NN cord-010092-uftc8inx 259 7 , , , cord-010092-uftc8inx 259 8 however however RB cord-010092-uftc8inx 259 9 , , , cord-010092-uftc8inx 259 10 mere mere JJ cord-010092-uftc8inx 259 11 mathematic mathematic JJ cord-010092-uftc8inx 259 12 validation validation NN cord-010092-uftc8inx 259 13 is be VBZ cord-010092-uftc8inx 259 14 required require VBN cord-010092-uftc8inx 259 15 . . . cord-010092-uftc8inx 260 1 This this DT cord-010092-uftc8inx 260 2 can can MD cord-010092-uftc8inx 260 3 be be VB cord-010092-uftc8inx 260 4 achieved achieve VBN cord-010092-uftc8inx 260 5 on on IN cord-010092-uftc8inx 260 6 retrospective retrospective JJ cord-010092-uftc8inx 260 7 datasets dataset NNS cord-010092-uftc8inx 260 8 . . . cord-010092-uftc8inx 261 1 In in IN cord-010092-uftc8inx 261 2 reality reality NN cord-010092-uftc8inx 261 3 , , , cord-010092-uftc8inx 261 4 we -PRON- PRP cord-010092-uftc8inx 261 5 need need VBP cord-010092-uftc8inx 261 6 more more JJR cord-010092-uftc8inx 261 7 before before IN cord-010092-uftc8inx 261 8 we -PRON- PRP cord-010092-uftc8inx 261 9 can can MD cord-010092-uftc8inx 261 10 use use VB cord-010092-uftc8inx 261 11 these these DT cord-010092-uftc8inx 261 12 algorithms algorithm NNS cord-010092-uftc8inx 261 13 to to TO cord-010092-uftc8inx 261 14 support support VB cord-010092-uftc8inx 261 15 our -PRON- PRP$ cord-010092-uftc8inx 261 16 decision decision NN cord-010092-uftc8inx 261 17 - - HYPH cord-010092-uftc8inx 261 18 making making NN cord-010092-uftc8inx 261 19 ; ; : cord-010092-uftc8inx 261 20 After after IN cord-010092-uftc8inx 261 21 internal internal JJ cord-010092-uftc8inx 261 22 ( ( -LRB- cord-010092-uftc8inx 261 23 retrospective retrospective JJ cord-010092-uftc8inx 261 24 ) ) -RRB- cord-010092-uftc8inx 261 25 and and CC cord-010092-uftc8inx 261 26 external external JJ cord-010092-uftc8inx 261 27 ( ( -LRB- cord-010092-uftc8inx 261 28 prospective prospective JJ cord-010092-uftc8inx 261 29 but but CC cord-010092-uftc8inx 261 30 passive passive JJ cord-010092-uftc8inx 261 31 use use NN cord-010092-uftc8inx 261 32 ) ) -RRB- cord-010092-uftc8inx 261 33 validation validation NN cord-010092-uftc8inx 261 34 steps step NNS cord-010092-uftc8inx 261 35 , , , cord-010092-uftc8inx 261 36 clinical clinical JJ cord-010092-uftc8inx 261 37 ( ( -LRB- cord-010092-uftc8inx 261 38 i.e. i.e. FW cord-010092-uftc8inx 261 39 RCT rct JJ cord-010092-uftc8inx 261 40 validation validation NN cord-010092-uftc8inx 261 41 is be VBZ cord-010092-uftc8inx 261 42 needed need VBN cord-010092-uftc8inx 261 43 . . . cord-010092-uftc8inx 262 1 Moreover moreover RB cord-010092-uftc8inx 262 2 , , , cord-010092-uftc8inx 262 3 we -PRON- PRP cord-010092-uftc8inx 262 4 will will MD cord-010092-uftc8inx 262 5 need need VB cord-010092-uftc8inx 262 6 to to TO cord-010092-uftc8inx 262 7 assess assess VB cord-010092-uftc8inx 262 8 the the DT cord-010092-uftc8inx 262 9 economic economic JJ cord-010092-uftc8inx 262 10 impact impact NN cord-010092-uftc8inx 262 11 too too RB cord-010092-uftc8inx 262 12 . . . cord-010092-uftc8inx 263 1 Ultimately ultimately RB cord-010092-uftc8inx 263 2 this this DT cord-010092-uftc8inx 263 3 tool tool NN cord-010092-uftc8inx 263 4 has have VBZ cord-010092-uftc8inx 263 5 now now RB cord-010092-uftc8inx 263 6 reached reach VBN cord-010092-uftc8inx 263 7 clinical clinical JJ cord-010092-uftc8inx 263 8 practice practice NN cord-010092-uftc8inx 263 9 and and CC cord-010092-uftc8inx 263 10 is be VBZ cord-010092-uftc8inx 263 11 starting start VBG cord-010092-uftc8inx 263 12 to to TO cord-010092-uftc8inx 263 13 help help VB cord-010092-uftc8inx 263 14 us -PRON- PRP cord-010092-uftc8inx 263 15 go go VB cord-010092-uftc8inx 263 16 from from IN cord-010092-uftc8inx 263 17 reactive reactive JJ cord-010092-uftc8inx 263 18 to to IN cord-010092-uftc8inx 263 19 more more RBR cord-010092-uftc8inx 263 20 proactive proactive JJ cord-010092-uftc8inx 263 21 hemodynamic hemodynamic JJ cord-010092-uftc8inx 263 22 management management NN cord-010092-uftc8inx 263 23 . . . cord-010092-uftc8inx 264 1 Like like IN cord-010092-uftc8inx 264 2 this this DT cord-010092-uftc8inx 264 3 , , , cord-010092-uftc8inx 264 4 we -PRON- PRP cord-010092-uftc8inx 264 5 have have VBP cord-010092-uftc8inx 264 6 started start VBN cord-010092-uftc8inx 264 7 to to TO cord-010092-uftc8inx 264 8 work work VB cord-010092-uftc8inx 264 9 on on IN cord-010092-uftc8inx 264 10 machine machine NN cord-010092-uftc8inx 264 11 - - HYPH cord-010092-uftc8inx 264 12 learning learn VBG cord-010092-uftc8inx 264 13 tools tool NNS cord-010092-uftc8inx 264 14 to to TO cord-010092-uftc8inx 264 15 predict predict VB cord-010092-uftc8inx 264 16 the the DT cord-010092-uftc8inx 264 17 incidence incidence NN cord-010092-uftc8inx 264 18 of of IN cord-010092-uftc8inx 264 19 specific specific JJ cord-010092-uftc8inx 264 20 types type NNS cord-010092-uftc8inx 264 21 of of IN cord-010092-uftc8inx 264 22 patients patient NNS cord-010092-uftc8inx 264 23 coming come VBG cord-010092-uftc8inx 264 24 into into IN cord-010092-uftc8inx 264 25 A&E A&E NNP cord-010092-uftc8inx 264 26 and and CC cord-010092-uftc8inx 264 27 predicting predict VBG cord-010092-uftc8inx 264 28 infections infection NNS cord-010092-uftc8inx 264 29 after after IN cord-010092-uftc8inx 264 30 surgery surgery NN cord-010092-uftc8inx 264 31 . . . cord-010092-uftc8inx 265 1 We -PRON- PRP cord-010092-uftc8inx 265 2 will will MD cord-010092-uftc8inx 265 3 discuss discuss VB cord-010092-uftc8inx 265 4 our -PRON- PRP$ cord-010092-uftc8inx 265 5 approach approach NN cord-010092-uftc8inx 265 6 , , , cord-010092-uftc8inx 265 7 essentials essential NNS cord-010092-uftc8inx 265 8 to to TO cord-010092-uftc8inx 265 9 start start VB cord-010092-uftc8inx 265 10 with with IN cord-010092-uftc8inx 265 11 machine machine NN cord-010092-uftc8inx 265 12 learning learning NN cord-010092-uftc8inx 265 13 , , , cord-010092-uftc8inx 265 14 practical practical JJ cord-010092-uftc8inx 265 15 learnings learning NNS cord-010092-uftc8inx 265 16 . . . cord-010092-uftc8inx 266 1 We -PRON- PRP cord-010092-uftc8inx 266 2 will will MD cord-010092-uftc8inx 266 3 also also RB cord-010092-uftc8inx 266 4 discuss discuss VB cord-010092-uftc8inx 266 5 a a DT cord-010092-uftc8inx 266 6 first first JJ cord-010092-uftc8inx 266 7 project project NN cord-010092-uftc8inx 266 8 design design NN cord-010092-uftc8inx 266 9 to to TO cord-010092-uftc8inx 266 10 use use VB cord-010092-uftc8inx 266 11 machine machine NN cord-010092-uftc8inx 266 12 learning learn VBG cord-010092-uftc8inx 266 13 in in IN cord-010092-uftc8inx 266 14 managing manage VBG cord-010092-uftc8inx 266 15 bleeding bleed VBG cord-010092-uftc8inx 266 16 patients patient NNS cord-010092-uftc8inx 266 17 to to TO cord-010092-uftc8inx 266 18 get get VB cord-010092-uftc8inx 266 19 the the DT cord-010092-uftc8inx 266 20 best good JJS cord-010092-uftc8inx 266 21 therapy therapy NN cord-010092-uftc8inx 266 22 advice advice NN cord-010092-uftc8inx 266 23 for for IN cord-010092-uftc8inx 266 24 blood blood NN cord-010092-uftc8inx 266 25 product product NN cord-010092-uftc8inx 266 26 use use NN cord-010092-uftc8inx 266 27 like like IN cord-010092-uftc8inx 266 28 plasma plasma NN cord-010092-uftc8inx 266 29 , , , cord-010092-uftc8inx 266 30 fibrinogen fibrinogen NN cord-010092-uftc8inx 266 31 et et NNP cord-010092-uftc8inx 266 32 cetera cetera NN cord-010092-uftc8inx 266 33 . . . cord-010092-uftc8inx 267 1 How how WRB cord-010092-uftc8inx 267 2 can can MD cord-010092-uftc8inx 267 3 we -PRON- PRP cord-010092-uftc8inx 267 4 start start VB cord-010092-uftc8inx 267 5 using use VBG cord-010092-uftc8inx 267 6 this this DT cord-010092-uftc8inx 267 7 tool tool NN cord-010092-uftc8inx 267 8 in in IN cord-010092-uftc8inx 267 9 unison unison NN cord-010092-uftc8inx 267 10 with with IN cord-010092-uftc8inx 267 11 our -PRON- PRP$ cord-010092-uftc8inx 267 12 existing exist VBG cord-010092-uftc8inx 267 13 tools tool NNS cord-010092-uftc8inx 267 14 to to TO cord-010092-uftc8inx 267 15 improve improve VB cord-010092-uftc8inx 267 16 science science NN cord-010092-uftc8inx 267 17 and and CC cord-010092-uftc8inx 267 18 clinical clinical JJ cord-010092-uftc8inx 267 19 practice practice NN cord-010092-uftc8inx 267 20 in in IN cord-010092-uftc8inx 267 21 our -PRON- PRP$ cord-010092-uftc8inx 267 22 respective respective JJ cord-010092-uftc8inx 267 23 ( ( -LRB- cord-010092-uftc8inx 267 24 bio)medical bio)medical JJ cord-010092-uftc8inx 267 25 fields field NNS cord-010092-uftc8inx 267 26 ? ? . cord-010092-uftc8inx 268 1 Thrombocytopenia Thrombocytopenia NNP cord-010092-uftc8inx 268 2 is be VBZ cord-010092-uftc8inx 268 3 a a DT cord-010092-uftc8inx 268 4 very very RB cord-010092-uftc8inx 268 5 common common JJ cord-010092-uftc8inx 268 6 hematological hematological JJ cord-010092-uftc8inx 268 7 abnormality abnormality NN cord-010092-uftc8inx 268 8 found find VBN cord-010092-uftc8inx 268 9 in in IN cord-010092-uftc8inx 268 10 newborns newborn NNS cord-010092-uftc8inx 268 11 , , , cord-010092-uftc8inx 268 12 especially especially RB cord-010092-uftc8inx 268 13 in in IN cord-010092-uftc8inx 268 14 preterm preterm JJ cord-010092-uftc8inx 268 15 neonates neonate NNS cord-010092-uftc8inx 268 16 . . . cord-010092-uftc8inx 269 1 Two two CD cord-010092-uftc8inx 269 2 subgroups subgroup NNS cord-010092-uftc8inx 269 3 can can MD cord-010092-uftc8inx 269 4 be be VB cord-010092-uftc8inx 269 5 distinguished distinguish VBN cord-010092-uftc8inx 269 6 : : : cord-010092-uftc8inx 269 7 early early JJ cord-010092-uftc8inx 269 8 thrombocytopenia thrombocytopenia NN cord-010092-uftc8inx 269 9 , , , cord-010092-uftc8inx 269 10 occurring occur VBG cord-010092-uftc8inx 269 11 within within IN cord-010092-uftc8inx 269 12 the the DT cord-010092-uftc8inx 269 13 first first JJ cord-010092-uftc8inx 269 14 72 72 CD cord-010092-uftc8inx 269 15 h h NN cord-010092-uftc8inx 269 16 of of IN cord-010092-uftc8inx 269 17 life life NN cord-010092-uftc8inx 269 18 , , , cord-010092-uftc8inx 269 19 and and CC cord-010092-uftc8inx 269 20 late late JJ cord-010092-uftc8inx 269 21 thrombocytopenia thrombocytopenia NN cord-010092-uftc8inx 269 22 , , , cord-010092-uftc8inx 269 23 occurring occur VBG cord-010092-uftc8inx 269 24 after after IN cord-010092-uftc8inx 269 25 the the DT cord-010092-uftc8inx 269 26 first first JJ cord-010092-uftc8inx 269 27 72 72 CD cord-010092-uftc8inx 269 28 h h NN cord-010092-uftc8inx 269 29 of of IN cord-010092-uftc8inx 269 30 life life NN cord-010092-uftc8inx 269 31 . . . cord-010092-uftc8inx 270 1 Early early JJ cord-010092-uftc8inx 270 2 thrombocytopenia thrombocytopenia NN cord-010092-uftc8inx 270 3 is be VBZ cord-010092-uftc8inx 270 4 associated associate VBN cord-010092-uftc8inx 270 5 with with IN cord-010092-uftc8inx 270 6 intrauterine intrauterine JJ cord-010092-uftc8inx 270 7 growth growth NN cord-010092-uftc8inx 270 8 restriction restriction NN cord-010092-uftc8inx 270 9 , , , cord-010092-uftc8inx 270 10 whereas whereas IN cord-010092-uftc8inx 270 11 late late JJ cord-010092-uftc8inx 270 12 thrombocytopenia thrombocytopenia NN cord-010092-uftc8inx 270 13 is be VBZ cord-010092-uftc8inx 270 14 caused cause VBN cord-010092-uftc8inx 270 15 mainly mainly RB cord-010092-uftc8inx 270 16 by by IN cord-010092-uftc8inx 270 17 sepsis sepsis NN cord-010092-uftc8inx 270 18 and and CC cord-010092-uftc8inx 270 19 necrotizing necrotize VBG cord-010092-uftc8inx 270 20 enterocolitis enterocolitis NN cord-010092-uftc8inx 270 21 . . . cord-010092-uftc8inx 271 1 Platelet platelet NN cord-010092-uftc8inx 271 2 transfusions transfusion NNS cord-010092-uftc8inx 271 3 are be VBP cord-010092-uftc8inx 271 4 the the DT cord-010092-uftc8inx 271 5 hallmark hallmark NN cord-010092-uftc8inx 271 6 of of IN cord-010092-uftc8inx 271 7 the the DT cord-010092-uftc8inx 271 8 treatment treatment NN cord-010092-uftc8inx 271 9 of of IN cord-010092-uftc8inx 271 10 neonatal neonatal JJ cord-010092-uftc8inx 271 11 thrombocytopenia thrombocytopenia NN cord-010092-uftc8inx 271 12 . . . cord-010092-uftc8inx 272 1 Most Most JJS cord-010092-uftc8inx 272 2 of of IN cord-010092-uftc8inx 272 3 these these DT cord-010092-uftc8inx 272 4 transfusions transfusion NNS cord-010092-uftc8inx 272 5 are be VBP cord-010092-uftc8inx 272 6 prophylactic prophylactic JJ cord-010092-uftc8inx 272 7 , , , cord-010092-uftc8inx 272 8 which which WDT cord-010092-uftc8inx 272 9 means mean VBZ cord-010092-uftc8inx 272 10 they -PRON- PRP cord-010092-uftc8inx 272 11 are be VBP cord-010092-uftc8inx 272 12 given give VBN cord-010092-uftc8inx 272 13 in in IN cord-010092-uftc8inx 272 14 the the DT cord-010092-uftc8inx 272 15 absence absence NN cord-010092-uftc8inx 272 16 of of IN cord-010092-uftc8inx 272 17 bleeding bleed VBG cord-010092-uftc8inx 272 18 . . . cord-010092-uftc8inx 273 1 However however RB cord-010092-uftc8inx 273 2 , , , cord-010092-uftc8inx 273 3 the the DT cord-010092-uftc8inx 273 4 efficacy efficacy NN cord-010092-uftc8inx 273 5 of of IN cord-010092-uftc8inx 273 6 these these DT cord-010092-uftc8inx 273 7 transfusions transfusion NNS cord-010092-uftc8inx 273 8 in in IN cord-010092-uftc8inx 273 9 preventing prevent VBG cord-010092-uftc8inx 273 10 bleeding bleeding NN cord-010092-uftc8inx 273 11 has have VBZ cord-010092-uftc8inx 273 12 never never RB cord-010092-uftc8inx 273 13 been be VBN cord-010092-uftc8inx 273 14 proven prove VBN cord-010092-uftc8inx 273 15 . . . cord-010092-uftc8inx 274 1 In in IN cord-010092-uftc8inx 274 2 addition addition NN cord-010092-uftc8inx 274 3 , , , cord-010092-uftc8inx 274 4 risks risk NNS cord-010092-uftc8inx 274 5 of of IN cord-010092-uftc8inx 274 6 platelet platelet NN cord-010092-uftc8inx 274 7 transfusion transfusion NN cord-010092-uftc8inx 274 8 seem seem VBP cord-010092-uftc8inx 274 9 to to TO cord-010092-uftc8inx 274 10 be be VB cord-010092-uftc8inx 274 11 more more RBR cord-010092-uftc8inx 274 12 pronounced pronounced JJ cord-010092-uftc8inx 274 13 in in IN cord-010092-uftc8inx 274 14 preterm preterm JJ cord-010092-uftc8inx 274 15 neonates neonate NNS cord-010092-uftc8inx 274 16 . . . cord-010092-uftc8inx 275 1 Because because IN cord-010092-uftc8inx 275 2 of of IN cord-010092-uftc8inx 275 3 lack lack NN cord-010092-uftc8inx 275 4 of of IN cord-010092-uftc8inx 275 5 data datum NNS cord-010092-uftc8inx 275 6 , , , cord-010092-uftc8inx 275 7 platelet platelet NN cord-010092-uftc8inx 275 8 transfusion transfusion NN cord-010092-uftc8inx 275 9 guidelines guideline NNS cord-010092-uftc8inx 275 10 differ differ VBP cord-010092-uftc8inx 275 11 widely widely RB cord-010092-uftc8inx 275 12 between between IN cord-010092-uftc8inx 275 13 countries country NNS cord-010092-uftc8inx 275 14 . . . cord-010092-uftc8inx 276 1 In in IN cord-010092-uftc8inx 276 2 a a DT cord-010092-uftc8inx 276 3 recent recent JJ cord-010092-uftc8inx 276 4 randomized randomize VBN cord-010092-uftc8inx 276 5 controlled control VBN cord-010092-uftc8inx 276 6 trial trial NN cord-010092-uftc8inx 276 7 ( ( -LRB- cord-010092-uftc8inx 276 8 Planet-2 Planet-2 NNP cord-010092-uftc8inx 276 9 / / SYM cord-010092-uftc8inx 276 10 Matisse Matisse NNP cord-010092-uftc8inx 276 11 study study NN cord-010092-uftc8inx 276 12 ) ) -RRB- cord-010092-uftc8inx 276 13 among among IN cord-010092-uftc8inx 276 14 preterm preterm JJ cord-010092-uftc8inx 276 15 infants infant NNS cord-010092-uftc8inx 276 16 with with IN cord-010092-uftc8inx 276 17 severe severe JJ cord-010092-uftc8inx 276 18 thrombocytopenia thrombocytopenia NN cord-010092-uftc8inx 276 19 , , , cord-010092-uftc8inx 276 20 we -PRON- PRP cord-010092-uftc8inx 276 21 found find VBD cord-010092-uftc8inx 276 22 that that IN cord-010092-uftc8inx 276 23 those those DT cord-010092-uftc8inx 276 24 randomly randomly RB cord-010092-uftc8inx 276 25 assigned assign VBN cord-010092-uftc8inx 276 26 to to TO cord-010092-uftc8inx 276 27 receive receive VB cord-010092-uftc8inx 276 28 platelet platelet NN cord-010092-uftc8inx 276 29 transfusions transfusion NNS cord-010092-uftc8inx 276 30 at at IN cord-010092-uftc8inx 276 31 a a DT cord-010092-uftc8inx 276 32 platelet platelet NN cord-010092-uftc8inx 276 33 - - HYPH cord-010092-uftc8inx 276 34 count count NN cord-010092-uftc8inx 276 35 threshold threshold NN cord-010092-uftc8inx 276 36 of of IN cord-010092-uftc8inx 276 37 50 50 CD cord-010092-uftc8inx 276 38 9 9 CD cord-010092-uftc8inx 276 39 10 10 CD cord-010092-uftc8inx 276 40 9 9 CD cord-010092-uftc8inx 276 41 /L /L , cord-010092-uftc8inx 276 42 had have VBD cord-010092-uftc8inx 276 43 a a DT cord-010092-uftc8inx 276 44 significantly significantly RB cord-010092-uftc8inx 276 45 higher high JJR cord-010092-uftc8inx 276 46 rate rate NN cord-010092-uftc8inx 276 47 of of IN cord-010092-uftc8inx 276 48 death death NN cord-010092-uftc8inx 276 49 or or CC cord-010092-uftc8inx 276 50 major major JJ cord-010092-uftc8inx 276 51 bleeding bleeding NN cord-010092-uftc8inx 276 52 within within IN cord-010092-uftc8inx 276 53 28 28 CD cord-010092-uftc8inx 276 54 days day NNS cord-010092-uftc8inx 276 55 after after IN cord-010092-uftc8inx 276 56 randomization randomization NN cord-010092-uftc8inx 276 57 than than IN cord-010092-uftc8inx 276 58 those those DT cord-010092-uftc8inx 276 59 who who WP cord-010092-uftc8inx 276 60 received receive VBD cord-010092-uftc8inx 276 61 platelet platelet NN cord-010092-uftc8inx 276 62 transfusions transfusion NNS cord-010092-uftc8inx 276 63 at at IN cord-010092-uftc8inx 276 64 a a DT cord-010092-uftc8inx 276 65 platelet platelet NN cord-010092-uftc8inx 276 66 - - HYPH cord-010092-uftc8inx 276 67 count count NN cord-010092-uftc8inx 276 68 threshold threshold NN cord-010092-uftc8inx 276 69 of of IN cord-010092-uftc8inx 276 70 25 25 CD cord-010092-uftc8inx 276 71 9 9 CD cord-010092-uftc8inx 276 72 10 10 CD cord-010092-uftc8inx 276 73 9 9 CD cord-010092-uftc8inx 276 74 /L. /L. . cord-010092-uftc8inx 277 1 This this DT cord-010092-uftc8inx 277 2 presentation presentation NN cord-010092-uftc8inx 277 3 summarizes summarize VBZ cord-010092-uftc8inx 277 4 the the DT cord-010092-uftc8inx 277 5 current current JJ cord-010092-uftc8inx 277 6 understanding understanding NN cord-010092-uftc8inx 277 7 of of IN cord-010092-uftc8inx 277 8 etiology etiology NN cord-010092-uftc8inx 277 9 and and CC cord-010092-uftc8inx 277 10 management management NN cord-010092-uftc8inx 277 11 of of IN cord-010092-uftc8inx 277 12 neonatal neonatal JJ cord-010092-uftc8inx 277 13 thrombocytopenia thrombocytopenia NN cord-010092-uftc8inx 277 14 . . . cord-010092-uftc8inx 278 1 Transfusion transfusion NN cord-010092-uftc8inx 278 2 - - HYPH cord-010092-uftc8inx 278 3 associated associate VBN cord-010092-uftc8inx 278 4 circulatory circulatory JJ cord-010092-uftc8inx 278 5 overload overload NN cord-010092-uftc8inx 278 6 ( ( -LRB- cord-010092-uftc8inx 278 7 TACO TACO NNP cord-010092-uftc8inx 278 8 ) ) -RRB- cord-010092-uftc8inx 278 9 is be VBZ cord-010092-uftc8inx 278 10 a a DT cord-010092-uftc8inx 278 11 severe severe JJ cord-010092-uftc8inx 278 12 transfusion transfusion NN cord-010092-uftc8inx 278 13 adverse adverse JJ cord-010092-uftc8inx 278 14 reaction reaction NN cord-010092-uftc8inx 278 15 that that WDT cord-010092-uftc8inx 278 16 is be VBZ cord-010092-uftc8inx 278 17 associated associate VBN cord-010092-uftc8inx 278 18 with with IN cord-010092-uftc8inx 278 19 increased increase VBN cord-010092-uftc8inx 278 20 mortality mortality NN cord-010092-uftc8inx 278 21 and and CC cord-010092-uftc8inx 278 22 morbidity morbidity NN cord-010092-uftc8inx 278 23 . . . cord-010092-uftc8inx 279 1 The the DT cord-010092-uftc8inx 279 2 incidence incidence NN cord-010092-uftc8inx 279 3 of of IN cord-010092-uftc8inx 279 4 TACO taco NN cord-010092-uftc8inx 279 5 in in IN cord-010092-uftc8inx 279 6 adults adult NNS cord-010092-uftc8inx 279 7 varies vary VBZ cord-010092-uftc8inx 279 8 from from IN cord-010092-uftc8inx 279 9 1 1 CD cord-010092-uftc8inx 279 10 % % NN cord-010092-uftc8inx 279 11 to to TO cord-010092-uftc8inx 279 12 8 8 CD cord-010092-uftc8inx 279 13 % % NN cord-010092-uftc8inx 279 14 , , , cord-010092-uftc8inx 279 15 but but CC cord-010092-uftc8inx 279 16 is be VBZ cord-010092-uftc8inx 279 17 probably probably RB cord-010092-uftc8inx 279 18 underdiagnosed underdiagnosed JJ cord-010092-uftc8inx 279 19 and and CC cord-010092-uftc8inx 279 20 underreported underreported JJ cord-010092-uftc8inx 279 21 . . . cord-010092-uftc8inx 280 1 The the DT cord-010092-uftc8inx 280 2 incidence incidence NN cord-010092-uftc8inx 280 3 in in IN cord-010092-uftc8inx 280 4 the the DT cord-010092-uftc8inx 280 5 pediatric pediatric JJ cord-010092-uftc8inx 280 6 population population NN cord-010092-uftc8inx 280 7 is be VBZ cord-010092-uftc8inx 280 8 undetermined undetermined JJ cord-010092-uftc8inx 280 9 . . . cord-010092-uftc8inx 281 1 TACO taco NN cord-010092-uftc8inx 281 2 usually usually RB cord-010092-uftc8inx 281 3 occurs occur VBZ cord-010092-uftc8inx 281 4 in in IN cord-010092-uftc8inx 281 5 patients patient NNS cord-010092-uftc8inx 281 6 who who WP cord-010092-uftc8inx 281 7 receive receive VBP cord-010092-uftc8inx 281 8 a a DT cord-010092-uftc8inx 281 9 large large JJ cord-010092-uftc8inx 281 10 volume volume NN cord-010092-uftc8inx 281 11 of of IN cord-010092-uftc8inx 281 12 blood blood NN cord-010092-uftc8inx 281 13 product product NN cord-010092-uftc8inx 281 14 over over IN cord-010092-uftc8inx 281 15 a a DT cord-010092-uftc8inx 281 16 short short JJ cord-010092-uftc8inx 281 17 period period NN cord-010092-uftc8inx 281 18 of of IN cord-010092-uftc8inx 281 19 time time NN cord-010092-uftc8inx 281 20 . . . cord-010092-uftc8inx 282 1 It -PRON- PRP cord-010092-uftc8inx 282 2 is be VBZ cord-010092-uftc8inx 282 3 more more RBR cord-010092-uftc8inx 282 4 common common JJ cord-010092-uftc8inx 282 5 in in IN cord-010092-uftc8inx 282 6 patients patient NNS cord-010092-uftc8inx 282 7 with with IN cord-010092-uftc8inx 282 8 known know VBN cord-010092-uftc8inx 282 9 risk risk NN cord-010092-uftc8inx 282 10 factors factor NNS cord-010092-uftc8inx 282 11 such such JJ cord-010092-uftc8inx 282 12 as as IN cord-010092-uftc8inx 282 13 cardiovascular cardiovascular JJ cord-010092-uftc8inx 282 14 disease disease NN cord-010092-uftc8inx 282 15 , , , cord-010092-uftc8inx 282 16 renal renal JJ cord-010092-uftc8inx 282 17 failure failure NN cord-010092-uftc8inx 282 18 , , , cord-010092-uftc8inx 282 19 and and CC cord-010092-uftc8inx 282 20 older old JJR cord-010092-uftc8inx 282 21 or or CC cord-010092-uftc8inx 282 22 younger young JJR cord-010092-uftc8inx 282 23 age age NN cord-010092-uftc8inx 282 24 ( ( -LRB- cord-010092-uftc8inx 282 25 > > NFP cord-010092-uftc8inx 282 26 60 60 CD cord-010092-uftc8inx 282 27 years year NNS cord-010092-uftc8inx 282 28 or or CC cord-010092-uftc8inx 282 29 < < XX cord-010092-uftc8inx 282 30 3 3 CD cord-010092-uftc8inx 282 31 years year NNS cord-010092-uftc8inx 282 32 ) ) -RRB- cord-010092-uftc8inx 282 33 . . . cord-010092-uftc8inx 283 1 Hospitalised hospitalise VBN cord-010092-uftc8inx 283 2 patients patient NNS cord-010092-uftc8inx 283 3 and and CC cord-010092-uftc8inx 283 4 intensive intensive JJ cord-010092-uftc8inx 283 5 care care NN cord-010092-uftc8inx 283 6 patients patient NNS cord-010092-uftc8inx 283 7 are be VBP cord-010092-uftc8inx 283 8 also also RB cord-010092-uftc8inx 283 9 more more JJR cord-010092-uftc8inx 283 10 at at IN cord-010092-uftc8inx 283 11 risk risk NN cord-010092-uftc8inx 283 12 . . . cord-010092-uftc8inx 284 1 The the DT cord-010092-uftc8inx 284 2 typical typical JJ cord-010092-uftc8inx 284 3 presentation presentation NN cord-010092-uftc8inx 284 4 of of IN cord-010092-uftc8inx 284 5 TACO taco NN cord-010092-uftc8inx 284 6 is be VBZ cord-010092-uftc8inx 284 7 respiratory respiratory JJ cord-010092-uftc8inx 284 8 distress distress NN cord-010092-uftc8inx 284 9 ( ( -LRB- cord-010092-uftc8inx 284 10 dyspnea dyspnea NN cord-010092-uftc8inx 284 11 , , , cord-010092-uftc8inx 284 12 tachypnea tachypnea NNP cord-010092-uftc8inx 284 13 ) ) -RRB- cord-010092-uftc8inx 284 14 occurring occur VBG cord-010092-uftc8inx 284 15 within within IN cord-010092-uftc8inx 284 16 12 12 CD cord-010092-uftc8inx 284 17 h h NN cord-010092-uftc8inx 284 18 of of IN cord-010092-uftc8inx 284 19 a a DT cord-010092-uftc8inx 284 20 blood blood NN cord-010092-uftc8inx 284 21 transfusion transfusion NN cord-010092-uftc8inx 284 22 . . . cord-010092-uftc8inx 285 1 Associated associated JJ cord-010092-uftc8inx 285 2 signs sign NNS cord-010092-uftc8inx 285 3 and and CC cord-010092-uftc8inx 285 4 symptoms symptom NNS cord-010092-uftc8inx 285 5 are be VBP cord-010092-uftc8inx 285 6 hypoxia hypoxia NN cord-010092-uftc8inx 285 7 , , , cord-010092-uftc8inx 285 8 hypertension hypertension NN cord-010092-uftc8inx 285 9 , , , cord-010092-uftc8inx 285 10 tachycardia tachycardia NN cord-010092-uftc8inx 285 11 , , , cord-010092-uftc8inx 285 12 positive positive JJ cord-010092-uftc8inx 285 13 fluid fluid JJ cord-010092-uftc8inx 285 14 balance balance NN cord-010092-uftc8inx 285 15 , , , cord-010092-uftc8inx 285 16 high high JJ cord-010092-uftc8inx 285 17 central central JJ cord-010092-uftc8inx 285 18 venous venous JJ cord-010092-uftc8inx 285 19 pressure pressure NN cord-010092-uftc8inx 285 20 , , , cord-010092-uftc8inx 285 21 and and CC cord-010092-uftc8inx 285 22 acute acute JJ cord-010092-uftc8inx 285 23 or or CC cord-010092-uftc8inx 285 24 worsening worsen VBG cord-010092-uftc8inx 285 25 pulmonary pulmonary JJ cord-010092-uftc8inx 285 26 edema edema NN cord-010092-uftc8inx 285 27 on on IN cord-010092-uftc8inx 285 28 chest chest NN cord-010092-uftc8inx 285 29 X x NN cord-010092-uftc8inx 285 30 - - NN cord-010092-uftc8inx 285 31 ray ray NN cord-010092-uftc8inx 285 32 . . . cord-010092-uftc8inx 286 1 Echocardiography echocardiography NN cord-010092-uftc8inx 286 2 and and CC cord-010092-uftc8inx 286 3 measurement measurement NN cord-010092-uftc8inx 286 4 of of IN cord-010092-uftc8inx 286 5 brain brain NN cord-010092-uftc8inx 286 6 natriuretic natriuretic JJ cord-010092-uftc8inx 286 7 peptide peptide NN cord-010092-uftc8inx 286 8 ( ( -LRB- cord-010092-uftc8inx 286 9 BNP BNP NNP cord-010092-uftc8inx 286 10 ) ) -RRB- cord-010092-uftc8inx 286 11 or or CC cord-010092-uftc8inx 286 12 its -PRON- PRP$ cord-010092-uftc8inx 286 13 N n CD cord-010092-uftc8inx 286 14 - - HYPH cord-010092-uftc8inx 286 15 terminal terminal NN cord-010092-uftc8inx 286 16 prohormone prohormone NN cord-010092-uftc8inx 286 17 ( ( -LRB- cord-010092-uftc8inx 286 18 NT NT NNP cord-010092-uftc8inx 286 19 - - HYPH cord-010092-uftc8inx 286 20 proBNP proBNP NNP cord-010092-uftc8inx 286 21 ) ) -RRB- cord-010092-uftc8inx 286 22 is be VBZ cord-010092-uftc8inx 286 23 helpful helpful JJ cord-010092-uftc8inx 286 24 for for IN cord-010092-uftc8inx 286 25 diagnosis diagnosis NN cord-010092-uftc8inx 286 26 . . . cord-010092-uftc8inx 287 1 Several several JJ cord-010092-uftc8inx 287 2 definition definition NN cord-010092-uftc8inx 287 3 criteria criterion NNS cord-010092-uftc8inx 287 4 have have VBP cord-010092-uftc8inx 287 5 been be VBN cord-010092-uftc8inx 287 6 proposed propose VBN cord-010092-uftc8inx 287 7 for for IN cord-010092-uftc8inx 287 8 TACO taco NN cord-010092-uftc8inx 287 9 , , , cord-010092-uftc8inx 287 10 but but CC cord-010092-uftc8inx 287 11 none none NN cord-010092-uftc8inx 287 12 are be VBP cord-010092-uftc8inx 287 13 adapted adapt VBN cord-010092-uftc8inx 287 14 for for IN cord-010092-uftc8inx 287 15 children child NNS cord-010092-uftc8inx 287 16 , , , cord-010092-uftc8inx 287 17 particularly particularly RB cord-010092-uftc8inx 287 18 critically critically RB cord-010092-uftc8inx 287 19 - - HYPH cord-010092-uftc8inx 287 20 ill ill JJ cord-010092-uftc8inx 287 21 children child NNS cord-010092-uftc8inx 287 22 who who WP cord-010092-uftc8inx 287 23 are be VBP cord-010092-uftc8inx 287 24 more more JJR cord-010092-uftc8inx 287 25 at at IN cord-010092-uftc8inx 287 26 risk risk NN cord-010092-uftc8inx 287 27 . . . cord-010092-uftc8inx 288 1 This this DT cord-010092-uftc8inx 288 2 is be VBZ cord-010092-uftc8inx 288 3 probably probably RB cord-010092-uftc8inx 288 4 the the DT cord-010092-uftc8inx 288 5 main main JJ cord-010092-uftc8inx 288 6 reason reason NN cord-010092-uftc8inx 288 7 why why WRB cord-010092-uftc8inx 288 8 TACO taco NN cord-010092-uftc8inx 288 9 is be VBZ cord-010092-uftc8inx 288 10 even even RB cord-010092-uftc8inx 288 11 more more RBR cord-010092-uftc8inx 288 12 underdiagnosed underdiagnosed JJ cord-010092-uftc8inx 288 13 and and CC cord-010092-uftc8inx 288 14 underreported underreporte VBN cord-010092-uftc8inx 288 15 in in IN cord-010092-uftc8inx 288 16 the the DT cord-010092-uftc8inx 288 17 pediatric pediatric JJ cord-010092-uftc8inx 288 18 population population NN cord-010092-uftc8inx 288 19 . . . cord-010092-uftc8inx 289 1 In in IN cord-010092-uftc8inx 289 2 a a DT cord-010092-uftc8inx 289 3 recent recent JJ cord-010092-uftc8inx 289 4 study study NN cord-010092-uftc8inx 289 5 , , , cord-010092-uftc8inx 289 6 we -PRON- PRP cord-010092-uftc8inx 289 7 compared compare VBD cord-010092-uftc8inx 289 8 the the DT cord-010092-uftc8inx 289 9 incidence incidence NN cord-010092-uftc8inx 289 10 of of IN cord-010092-uftc8inx 289 11 TACO taco NN cord-010092-uftc8inx 289 12 in in IN cord-010092-uftc8inx 289 13 a a DT cord-010092-uftc8inx 289 14 pediatric pediatric JJ cord-010092-uftc8inx 289 15 intensive intensive JJ cord-010092-uftc8inx 289 16 care care NN cord-010092-uftc8inx 289 17 unit unit NN cord-010092-uftc8inx 289 18 using use VBG cord-010092-uftc8inx 289 19 the the DT cord-010092-uftc8inx 289 20 International International NNP cord-010092-uftc8inx 289 21 Society Society NNP cord-010092-uftc8inx 289 22 of of IN cord-010092-uftc8inx 289 23 Blood Blood NNP cord-010092-uftc8inx 289 24 Transfusion Transfusion NNP cord-010092-uftc8inx 289 25 ( ( -LRB- cord-010092-uftc8inx 289 26 ISBT ISBT NNP cord-010092-uftc8inx 289 27 ) ) -RRB- cord-010092-uftc8inx 289 28 criteria criterion NNS cord-010092-uftc8inx 289 29 , , , cord-010092-uftc8inx 289 30 with with IN cord-010092-uftc8inx 289 31 two two CD cord-010092-uftc8inx 289 32 different different JJ cord-010092-uftc8inx 289 33 ways way NNS cord-010092-uftc8inx 289 34 of of IN cord-010092-uftc8inx 289 35 defining define VBG cord-010092-uftc8inx 289 36 abnormal abnormal JJ cord-010092-uftc8inx 289 37 values value NNS cord-010092-uftc8inx 289 38 : : : cord-010092-uftc8inx 289 39 1 1 LS cord-010092-uftc8inx 289 40 ) ) -RRB- cord-010092-uftc8inx 289 41 using use VBG cord-010092-uftc8inx 289 42 normal normal JJ cord-010092-uftc8inx 289 43 pediatric pediatric JJ cord-010092-uftc8inx 289 44 values value NNS cord-010092-uftc8inx 289 45 published publish VBN cord-010092-uftc8inx 289 46 in in IN cord-010092-uftc8inx 289 47 the the DT cord-010092-uftc8inx 289 48 Nelson Nelson NNP cord-010092-uftc8inx 289 49 Textbook Textbook NNP cord-010092-uftc8inx 289 50 of of IN cord-010092-uftc8inx 289 51 Pediatrics Pediatrics NNP cord-010092-uftc8inx 289 52 ; ; : cord-010092-uftc8inx 289 53 and and CC cord-010092-uftc8inx 289 54 2 2 LS cord-010092-uftc8inx 289 55 ) ) -RRB- cord-010092-uftc8inx 289 56 using use VBG cord-010092-uftc8inx 289 57 patients patient NNS cord-010092-uftc8inx 289 58 as as IN cord-010092-uftc8inx 289 59 their -PRON- PRP$ cord-010092-uftc8inx 289 60 own own JJ cord-010092-uftc8inx 289 61 controls control NNS cord-010092-uftc8inx 289 62 and and CC cord-010092-uftc8inx 289 63 comparing compare VBG cord-010092-uftc8inx 289 64 pre pre JJ cord-010092-uftc8inx 289 65 - - JJ cord-010092-uftc8inx 289 66 and and CC cord-010092-uftc8inx 289 67 post post JJ cord-010092-uftc8inx 289 68 - - JJ cord-010092-uftc8inx 289 69 transfusion transfusion JJ cord-010092-uftc8inx 289 70 values value NNS cord-010092-uftc8inx 289 71 with with IN cord-010092-uftc8inx 289 72 either either CC cord-010092-uftc8inx 289 73 a a DT cord-010092-uftc8inx 289 74 10 10 CD cord-010092-uftc8inx 289 75 % % NN cord-010092-uftc8inx 289 76 or or CC cord-010092-uftc8inx 289 77 20 20 CD cord-010092-uftc8inx 289 78 % % NN cord-010092-uftc8inx 289 79 difference difference NN cord-010092-uftc8inx 289 80 threshold threshold NN cord-010092-uftc8inx 289 81 . . . cord-010092-uftc8inx 290 1 We -PRON- PRP cord-010092-uftc8inx 290 2 monitored monitor VBD cord-010092-uftc8inx 290 3 for for IN cord-010092-uftc8inx 290 4 TACO taco NN cord-010092-uftc8inx 290 5 up up RP cord-010092-uftc8inx 290 6 to to TO cord-010092-uftc8inx 290 7 24 24 CD cord-010092-uftc8inx 290 8 h h NN cord-010092-uftc8inx 290 9 post post NN cord-010092-uftc8inx 290 10 - - NN cord-010092-uftc8inx 290 11 transfusion transfusion NN cord-010092-uftc8inx 290 12 . . . cord-010092-uftc8inx 291 1 A a DT cord-010092-uftc8inx 291 2 total total NN cord-010092-uftc8inx 291 3 of of IN cord-010092-uftc8inx 291 4 136 136 CD cord-010092-uftc8inx 291 5 patients patient NNS cord-010092-uftc8inx 291 6 were be VBD cord-010092-uftc8inx 291 7 included include VBN cord-010092-uftc8inx 291 8 . . . cord-010092-uftc8inx 292 1 TACO taco NN cord-010092-uftc8inx 292 2 incidence incidence NN cord-010092-uftc8inx 292 3 varied varied JJ cord-010092-uftc8inx 292 4 from from IN cord-010092-uftc8inx 292 5 1.5 1.5 CD cord-010092-uftc8inx 292 6 % % NN cord-010092-uftc8inx 292 7 to to IN cord-010092-uftc8inx 292 8 76 76 CD cord-010092-uftc8inx 292 9 % % NN cord-010092-uftc8inx 292 10 , , , cord-010092-uftc8inx 292 11 depending depend VBG cord-010092-uftc8inx 292 12 on on IN cord-010092-uftc8inx 292 13 the the DT cord-010092-uftc8inx 292 14 definition definition NN cord-010092-uftc8inx 292 15 used use VBN cord-010092-uftc8inx 292 16 . . . cord-010092-uftc8inx 293 1 With with IN cord-010092-uftc8inx 293 2 such such JJ cord-010092-uftc8inx 293 3 wide wide JJ cord-010092-uftc8inx 293 4 variability variability NN cord-010092-uftc8inx 293 5 , , , cord-010092-uftc8inx 293 6 we -PRON- PRP cord-010092-uftc8inx 293 7 conclude conclude VBP cord-010092-uftc8inx 293 8 that that IN cord-010092-uftc8inx 293 9 a a DT cord-010092-uftc8inx 293 10 more more RBR cord-010092-uftc8inx 293 11 operational operational JJ cord-010092-uftc8inx 293 12 definition definition NN cord-010092-uftc8inx 293 13 of of IN cord-010092-uftc8inx 293 14 TACO taco NN cord-010092-uftc8inx 293 15 is be VBZ cord-010092-uftc8inx 293 16 needed need VBN cord-010092-uftc8inx 293 17 in in IN cord-010092-uftc8inx 293 18 pediatrics pediatric NNS cord-010092-uftc8inx 293 19 , , , cord-010092-uftc8inx 293 20 particularly particularly RB cord-010092-uftc8inx 293 21 for for IN cord-010092-uftc8inx 293 22 critically critically RB cord-010092-uftc8inx 293 23 - - HYPH cord-010092-uftc8inx 293 24 ill ill JJ cord-010092-uftc8inx 293 25 children child NNS cord-010092-uftc8inx 293 26 . . . cord-010092-uftc8inx 294 1 Differential differential JJ cord-010092-uftc8inx 294 2 diagnosis diagnosis NN cord-010092-uftc8inx 294 3 from from IN cord-010092-uftc8inx 294 4 other other JJ cord-010092-uftc8inx 294 5 dyspnea dyspnea NN cord-010092-uftc8inx 294 6 - - HYPH cord-010092-uftc8inx 294 7 associated associate VBN cord-010092-uftc8inx 294 8 transfusion transfusion NN cord-010092-uftc8inx 294 9 adverse adverse JJ cord-010092-uftc8inx 294 10 reactions reaction NNS cord-010092-uftc8inx 294 11 ( ( -LRB- cord-010092-uftc8inx 294 12 e.g. e.g. IN cord-010092-uftc8inx 294 13 transfusion transfusion NN cord-010092-uftc8inx 294 14 - - HYPH cord-010092-uftc8inx 294 15 associated associate VBN cord-010092-uftc8inx 294 16 lung lung NN cord-010092-uftc8inx 294 17 injury injury NN cord-010092-uftc8inx 294 18 , , , cord-010092-uftc8inx 294 19 anaphylaxis anaphylaxis NN cord-010092-uftc8inx 294 20 ) ) -RRB- cord-010092-uftc8inx 294 21 is be VBZ cord-010092-uftc8inx 294 22 important important JJ cord-010092-uftc8inx 294 23 because because IN cord-010092-uftc8inx 294 24 treatment treatment NN cord-010092-uftc8inx 294 25 differs differ VBZ cord-010092-uftc8inx 294 26 , , , cord-010092-uftc8inx 294 27 as as IN cord-010092-uftc8inx 294 28 do do VBP cord-010092-uftc8inx 294 29 guidelines guideline NNS cord-010092-uftc8inx 294 30 to to IN cord-010092-uftc8inx 294 31 the the DT cord-010092-uftc8inx 294 32 blood blood NN cord-010092-uftc8inx 294 33 bank bank NN cord-010092-uftc8inx 294 34 . . . cord-010092-uftc8inx 295 1 Treatment treatment NN cord-010092-uftc8inx 295 2 for for IN cord-010092-uftc8inx 295 3 TACO taco NN cord-010092-uftc8inx 295 4 is be VBZ cord-010092-uftc8inx 295 5 similar similar JJ cord-010092-uftc8inx 295 6 to to IN cord-010092-uftc8inx 295 7 that that DT cord-010092-uftc8inx 295 8 of of IN cord-010092-uftc8inx 295 9 any any DT cord-010092-uftc8inx 295 10 other other JJ cord-010092-uftc8inx 295 11 cardiogenic cardiogenic JJ cord-010092-uftc8inx 295 12 pulmonary pulmonary JJ cord-010092-uftc8inx 295 13 edema edema NN cord-010092-uftc8inx 295 14 : : : cord-010092-uftc8inx 295 15 oxygen oxygen NN cord-010092-uftc8inx 295 16 , , , cord-010092-uftc8inx 295 17 diuresis diuresis NN cord-010092-uftc8inx 295 18 , , , cord-010092-uftc8inx 295 19 ventilatory ventilatory JJ cord-010092-uftc8inx 295 20 support support NN cord-010092-uftc8inx 295 21 . . . cord-010092-uftc8inx 296 1 Prevention prevention NN cord-010092-uftc8inx 296 2 is be VBZ cord-010092-uftc8inx 296 3 possible possible JJ cord-010092-uftc8inx 296 4 by by IN cord-010092-uftc8inx 296 5 avoiding avoid VBG cord-010092-uftc8inx 296 6 unnecessary unnecessary JJ cord-010092-uftc8inx 296 7 transfusions transfusion NNS cord-010092-uftc8inx 296 8 , , , cord-010092-uftc8inx 296 9 transfusing transfuse VBG cord-010092-uftc8inx 296 10 only only RB cord-010092-uftc8inx 296 11 the the DT cord-010092-uftc8inx 296 12 necessary necessary JJ cord-010092-uftc8inx 296 13 amount amount NN cord-010092-uftc8inx 296 14 of of IN cord-010092-uftc8inx 296 15 blood blood NN cord-010092-uftc8inx 296 16 product product NN cord-010092-uftc8inx 296 17 , , , cord-010092-uftc8inx 296 18 avoiding avoid VBG cord-010092-uftc8inx 296 19 rapid rapid JJ cord-010092-uftc8inx 296 20 transfusions transfusion NNS cord-010092-uftc8inx 296 21 , , , cord-010092-uftc8inx 296 22 and and CC cord-010092-uftc8inx 296 23 using use VBG cord-010092-uftc8inx 296 24 diuretics diuretic NNS cord-010092-uftc8inx 296 25 . . . cord-010092-uftc8inx 297 1 Background background NN cord-010092-uftc8inx 297 2 : : : cord-010092-uftc8inx 298 1 The the DT cord-010092-uftc8inx 298 2 risk risk NN cord-010092-uftc8inx 298 3 and and CC cord-010092-uftc8inx 298 4 importance importance NN cord-010092-uftc8inx 298 5 of of IN cord-010092-uftc8inx 298 6 transfusion transfusion NN cord-010092-uftc8inx 298 7 - - HYPH cord-010092-uftc8inx 298 8 transmitted transmit VBN cord-010092-uftc8inx 298 9 hepatitis hepatitis NN cord-010092-uftc8inx 298 10 E e NN cord-010092-uftc8inx 298 11 virus virus NN cord-010092-uftc8inx 298 12 ( ( -LRB- cord-010092-uftc8inx 298 13 TT TT NNP cord-010092-uftc8inx 298 14 - - HYPH cord-010092-uftc8inx 298 15 HEV HEV NNP cord-010092-uftc8inx 298 16 ) ) -RRB- cord-010092-uftc8inx 298 17 infections infection NNS cord-010092-uftc8inx 298 18 by by IN cord-010092-uftc8inx 298 19 contaminated contaminated JJ cord-010092-uftc8inx 298 20 blood blood NN cord-010092-uftc8inx 298 21 is be VBZ cord-010092-uftc8inx 298 22 currently currently RB cord-010092-uftc8inx 298 23 a a DT cord-010092-uftc8inx 298 24 controversial controversial JJ cord-010092-uftc8inx 298 25 discussed discuss VBN cord-010092-uftc8inx 298 26 topic topic NN cord-010092-uftc8inx 298 27 in in IN cord-010092-uftc8inx 298 28 transfusion transfusion NN cord-010092-uftc8inx 298 29 medicine medicine NN cord-010092-uftc8inx 298 30 . . . cord-010092-uftc8inx 299 1 In in IN cord-010092-uftc8inx 299 2 particular particular JJ cord-010092-uftc8inx 299 3 , , , cord-010092-uftc8inx 299 4 the the DT cord-010092-uftc8inx 299 5 infectious infectious JJ cord-010092-uftc8inx 299 6 dose dose NN cord-010092-uftc8inx 299 7 is be VBZ cord-010092-uftc8inx 299 8 a a DT cord-010092-uftc8inx 299 9 not not RB cord-010092-uftc8inx 299 10 finally finally RB cord-010092-uftc8inx 299 11 determined determine VBN cord-010092-uftc8inx 299 12 quantity quantity NN cord-010092-uftc8inx 299 13 . . . cord-010092-uftc8inx 300 1 The the DT cord-010092-uftc8inx 300 2 different different JJ cord-010092-uftc8inx 300 3 countries country NNS cord-010092-uftc8inx 300 4 have have VBP cord-010092-uftc8inx 300 5 chosen choose VBN cord-010092-uftc8inx 300 6 different different JJ cord-010092-uftc8inx 300 7 approaches approach NNS cord-010092-uftc8inx 300 8 to to TO cord-010092-uftc8inx 300 9 deal deal VB cord-010092-uftc8inx 300 10 with with IN cord-010092-uftc8inx 300 11 this this DT cord-010092-uftc8inx 300 12 pathogen pathogen NN cord-010092-uftc8inx 300 13 . . . cord-010092-uftc8inx 301 1 One one CD cord-010092-uftc8inx 301 2 central central JJ cord-010092-uftc8inx 301 3 question question NN cord-010092-uftc8inx 301 4 is be VBZ cord-010092-uftc8inx 301 5 the the DT cord-010092-uftc8inx 301 6 need need NN cord-010092-uftc8inx 301 7 of of IN cord-010092-uftc8inx 301 8 individual individual JJ cord-010092-uftc8inx 301 9 NAT NAT NNP cord-010092-uftc8inx 301 10 screening screening NN cord-010092-uftc8inx 301 11 ( ( -LRB- cord-010092-uftc8inx 301 12 ID ID NNP cord-010092-uftc8inx 301 13 ) ) -RRB- cord-010092-uftc8inx 301 14 versus versus IN cord-010092-uftc8inx 301 15 minipool minipool JJ cord-010092-uftc8inx 301 16 NAT NAT NNP cord-010092-uftc8inx 301 17 screening screening NN cord-010092-uftc8inx 301 18 ( ( -LRB- cord-010092-uftc8inx 301 19 MP MP NNP cord-010092-uftc8inx 301 20 ) ) -RRB- cord-010092-uftc8inx 301 21 approaches approach VBZ cord-010092-uftc8inx 301 22 to to TO cord-010092-uftc8inx 301 23 identify identify VB cord-010092-uftc8inx 301 24 all all DT cord-010092-uftc8inx 301 25 relevant relevant JJ cord-010092-uftc8inx 301 26 viremias viremias NN cord-010092-uftc8inx 301 27 in in IN cord-010092-uftc8inx 301 28 blood blood NN cord-010092-uftc8inx 301 29 donors donor NNS cord-010092-uftc8inx 301 30 . . . cord-010092-uftc8inx 302 1 Aims aim VBZ cord-010092-uftc8inx 302 2 : : : cord-010092-uftc8inx 303 1 Comparison comparison NN cord-010092-uftc8inx 303 2 and and CC cord-010092-uftc8inx 303 3 evaluation evaluation NN cord-010092-uftc8inx 303 4 of of IN cord-010092-uftc8inx 303 5 the the DT cord-010092-uftc8inx 303 6 available available JJ cord-010092-uftc8inx 303 7 screening screening NN cord-010092-uftc8inx 303 8 strategies strategy NNS cord-010092-uftc8inx 303 9 in in IN cord-010092-uftc8inx 303 10 relation relation NN cord-010092-uftc8inx 303 11 to to IN cord-010092-uftc8inx 303 12 the the DT cord-010092-uftc8inx 303 13 infectious infectious JJ cord-010092-uftc8inx 303 14 dose dose NN cord-010092-uftc8inx 303 15 to to TO cord-010092-uftc8inx 303 16 minimize minimize VB cord-010092-uftc8inx 303 17 the the DT cord-010092-uftc8inx 303 18 risk risk NN cord-010092-uftc8inx 303 19 of of IN cord-010092-uftc8inx 303 20 TT TT NNP cord-010092-uftc8inx 303 21 - - HYPH cord-010092-uftc8inx 303 22 HEV HEV NNP cord-010092-uftc8inx 303 23 infections infection NNS cord-010092-uftc8inx 303 24 . . . cord-010092-uftc8inx 304 1 Methods method NNS cord-010092-uftc8inx 304 2 : : : cord-010092-uftc8inx 304 3 We -PRON- PRP cord-010092-uftc8inx 304 4 systematically systematically RB cord-010092-uftc8inx 304 5 reviewed review VBD cord-010092-uftc8inx 304 6 the the DT cord-010092-uftc8inx 304 7 presently presently RB cord-010092-uftc8inx 304 8 known know VBN cord-010092-uftc8inx 304 9 cases case NNS cord-010092-uftc8inx 304 10 of of IN cord-010092-uftc8inx 304 11 TT TT NNP cord-010092-uftc8inx 304 12 - - HYPH cord-010092-uftc8inx 304 13 HEV HEV NNP cord-010092-uftc8inx 304 14 infections infection NNS cord-010092-uftc8inx 304 15 and and CC cord-010092-uftc8inx 304 16 available available JJ cord-010092-uftc8inx 304 17 routine routine JJ cord-010092-uftc8inx 304 18 NAT NAT NNP cord-010092-uftc8inx 304 19 - - HYPH cord-010092-uftc8inx 304 20 screening screen VBG cord-010092-uftc8inx 304 21 assays assay NNS cord-010092-uftc8inx 304 22 . . . cord-010092-uftc8inx 305 1 Furthermore furthermore RB cord-010092-uftc8inx 305 2 , , , cord-010092-uftc8inx 305 3 blood blood NN cord-010092-uftc8inx 305 4 donation donation NN cord-010092-uftc8inx 305 5 screening screening NN cord-010092-uftc8inx 305 6 strategies strategy NNS cord-010092-uftc8inx 305 7 for for IN cord-010092-uftc8inx 305 8 HEV HEV NNP cord-010092-uftc8inx 305 9 EHEV EHEV NNP cord-010092-uftc8inx 305 10 in in IN cord-010092-uftc8inx 305 11 effect effect NN cord-010092-uftc8inx 305 12 in in IN cord-010092-uftc8inx 305 13 the the DT cord-010092-uftc8inx 305 14 European European NNP cord-010092-uftc8inx 305 15 Union Union NNP cord-010092-uftc8inx 305 16 were be VBD cord-010092-uftc8inx 305 17 compared compare VBN cord-010092-uftc8inx 305 18 . . . cord-010092-uftc8inx 306 1 We -PRON- PRP cord-010092-uftc8inx 306 2 also also RB cord-010092-uftc8inx 306 3 describe describe VBP cord-010092-uftc8inx 306 4 our -PRON- PRP$ cord-010092-uftc8inx 306 5 own own JJ cord-010092-uftc8inx 306 6 experiences experience NNS cord-010092-uftc8inx 306 7 of of IN cord-010092-uftc8inx 306 8 HEV HEV NNP cord-010092-uftc8inx 306 9 screening screening NN cord-010092-uftc8inx 306 10 utilising utilise VBG cord-010092-uftc8inx 306 11 an an DT cord-010092-uftc8inx 306 12 ID ID NNP cord-010092-uftc8inx 306 13 - - HYPH cord-010092-uftc8inx 306 14 NAT NAT NNP cord-010092-uftc8inx 306 15 - - HYPH cord-010092-uftc8inx 306 16 based base VBN cord-010092-uftc8inx 306 17 donor donor NN cord-010092-uftc8inx 306 18 screening screening NN cord-010092-uftc8inx 306 19 algorithm algorithm NN cord-010092-uftc8inx 306 20 compared compare VBN cord-010092-uftc8inx 306 21 to to IN cord-010092-uftc8inx 306 22 MP MP NNP cord-010092-uftc8inx 306 23 - - HYPH cord-010092-uftc8inx 306 24 NAT NAT NNP cord-010092-uftc8inx 306 25 in in IN cord-010092-uftc8inx 306 26 pools pool NNS cord-010092-uftc8inx 306 27 of of IN cord-010092-uftc8inx 306 28 96 96 CD cord-010092-uftc8inx 306 29 samples sample NNS cord-010092-uftc8inx 306 30 . . . cord-010092-uftc8inx 307 1 From from IN cord-010092-uftc8inx 307 2 November November NNP cord-010092-uftc8inx 307 3 2017 2017 CD cord-010092-uftc8inx 307 4 to to IN cord-010092-uftc8inx 307 5 January January NNP cord-010092-uftc8inx 307 6 2018 2018 CD cord-010092-uftc8inx 307 7 , , , cord-010092-uftc8inx 307 8 a a DT cord-010092-uftc8inx 307 9 total total NN cord-010092-uftc8inx 307 10 of of IN cord-010092-uftc8inx 307 11 10,141 10,141 CD cord-010092-uftc8inx 307 12 blood blood NN cord-010092-uftc8inx 307 13 donations donation NNS cord-010092-uftc8inx 307 14 were be VBD cord-010092-uftc8inx 307 15 screened screen VBN cord-010092-uftc8inx 307 16 for for IN cord-010092-uftc8inx 307 17 the the DT cord-010092-uftc8inx 307 18 presence presence NN cord-010092-uftc8inx 307 19 of of IN cord-010092-uftc8inx 307 20 HEV HEV NNP cord-010092-uftc8inx 307 21 RNA RNA NNP cord-010092-uftc8inx 307 22 using use VBG cord-010092-uftc8inx 307 23 a a DT cord-010092-uftc8inx 307 24 MP MP NNP cord-010092-uftc8inx 307 25 - - HYPH cord-010092-uftc8inx 307 26 NAT NAT NNP cord-010092-uftc8inx 307 27 ( ( -LRB- cord-010092-uftc8inx 307 28 in in IN cord-010092-uftc8inx 307 29 house house NN cord-010092-uftc8inx 307 30 , , , cord-010092-uftc8inx 307 31 RealStar RealStar NNP cord-010092-uftc8inx 307 32 HEV HEV NNP cord-010092-uftc8inx 307 33 RT RT NNP cord-010092-uftc8inx 307 34 - - HYPH cord-010092-uftc8inx 307 35 PCR PCR NNP cord-010092-uftc8inx 307 36 Kit kit NN cord-010092-uftc8inx 307 37 ) ) -RRB- cord-010092-uftc8inx 307 38 and and CC cord-010092-uftc8inx 307 39 an an DT cord-010092-uftc8inx 307 40 ID ID NNP cord-010092-uftc8inx 307 41 - - HYPH cord-010092-uftc8inx 307 42 NAT NAT NNP cord-010092-uftc8inx 307 43 ( ( -LRB- cord-010092-uftc8inx 307 44 cobas cobas NNP cord-010092-uftc8inx 307 45 6800 6800 CD cord-010092-uftc8inx 307 46 platform platform NN cord-010092-uftc8inx 307 47 ) ) -RRB- cord-010092-uftc8inx 307 48 . . . cord-010092-uftc8inx 308 1 Results result NNS cord-010092-uftc8inx 308 2 : : : cord-010092-uftc8inx 309 1 The the DT cord-010092-uftc8inx 309 2 review review NN cord-010092-uftc8inx 309 3 of of IN cord-010092-uftc8inx 309 4 the the DT cord-010092-uftc8inx 309 5 literature literature NN cord-010092-uftc8inx 309 6 revealed reveal VBD cord-010092-uftc8inx 309 7 a a DT cord-010092-uftc8inx 309 8 significant significant JJ cord-010092-uftc8inx 309 9 variation variation NN cord-010092-uftc8inx 309 10 regarding regard VBG cord-010092-uftc8inx 309 11 the the DT cord-010092-uftc8inx 309 12 infectious infectious JJ cord-010092-uftc8inx 309 13 dose dose NN cord-010092-uftc8inx 309 14 causing cause VBG cord-010092-uftc8inx 309 15 hepatitis hepatitis NN cord-010092-uftc8inx 309 16 E. E. NNP cord-010092-uftc8inx 310 1 In in IN cord-010092-uftc8inx 310 2 the the DT cord-010092-uftc8inx 310 3 systematic systematic JJ cord-010092-uftc8inx 310 4 case case NN cord-010092-uftc8inx 310 5 review review NN cord-010092-uftc8inx 310 6 , , , cord-010092-uftc8inx 310 7 all all DT cord-010092-uftc8inx 310 8 components component NNS cord-010092-uftc8inx 310 9 with with IN cord-010092-uftc8inx 310 10 a a DT cord-010092-uftc8inx 310 11 viral viral JJ cord-010092-uftc8inx 310 12 load load NN cord-010092-uftc8inx 310 13 ( ( -LRB- cord-010092-uftc8inx 310 14 VL VL NNP cord-010092-uftc8inx 310 15 ) ) -RRB- cord-010092-uftc8inx 310 16 greater great JJR cord-010092-uftc8inx 310 17 than than IN cord-010092-uftc8inx 310 18 5.00E+04 5.00e+04 CD cord-010092-uftc8inx 310 19 IU IU NNP cord-010092-uftc8inx 310 20 caused cause VBD cord-010092-uftc8inx 310 21 infection infection NN cord-010092-uftc8inx 310 22 ( ( -LRB- cord-010092-uftc8inx 310 23 definitive definitive JJ cord-010092-uftc8inx 310 24 infectious infectious JJ cord-010092-uftc8inx 310 25 dose dose NN cord-010092-uftc8inx 310 26 ( ( -LRB- cord-010092-uftc8inx 310 27 DIFD DIFD NNP cord-010092-uftc8inx 310 28 ) ) -RRB- cord-010092-uftc8inx 310 29 . . . cord-010092-uftc8inx 311 1 The the DT cord-010092-uftc8inx 311 2 lowest low JJS cord-010092-uftc8inx 311 3 infectious infectious JJ cord-010092-uftc8inx 311 4 dose dose NN cord-010092-uftc8inx 311 5 resulting result VBG cord-010092-uftc8inx 311 6 in in IN cord-010092-uftc8inx 311 7 TT TT NNP cord-010092-uftc8inx 311 8 - - HYPH cord-010092-uftc8inx 311 9 HEV HEV NNP cord-010092-uftc8inx 311 10 infection infection NN cord-010092-uftc8inx 311 11 observed observe VBN cord-010092-uftc8inx 311 12 in in IN cord-010092-uftc8inx 311 13 general general JJ cord-010092-uftc8inx 311 14 was be VBD cord-010092-uftc8inx 311 15 7.05E+03 7.05e+03 CD cord-010092-uftc8inx 311 16 IU IU NNP cord-010092-uftc8inx 311 17 ( ( -LRB- cord-010092-uftc8inx 311 18 minimal minimal JJ cord-010092-uftc8inx 311 19 infectious infectious JJ cord-010092-uftc8inx 311 20 dose dose NN cord-010092-uftc8inx 311 21 ( ( -LRB- cord-010092-uftc8inx 311 22 MIFD MIFD NNP cord-010092-uftc8inx 311 23 ) ) -RRB- cord-010092-uftc8inx 311 24 . . . cord-010092-uftc8inx 312 1 The the DT cord-010092-uftc8inx 312 2 infectious infectious JJ cord-010092-uftc8inx 312 3 dose dose NN cord-010092-uftc8inx 312 4 of of IN cord-010092-uftc8inx 312 5 the the DT cord-010092-uftc8inx 312 6 different different JJ cord-010092-uftc8inx 312 7 blood blood NN cord-010092-uftc8inx 312 8 products product NNS cord-010092-uftc8inx 312 9 is be VBZ cord-010092-uftc8inx 312 10 mainly mainly RB cord-010092-uftc8inx 312 11 influenced influence VBN cord-010092-uftc8inx 312 12 by by IN cord-010092-uftc8inx 312 13 the the DT cord-010092-uftc8inx 312 14 remaining remain VBG cord-010092-uftc8inx 312 15 plasma plasma NN cord-010092-uftc8inx 312 16 content content NN cord-010092-uftc8inx 312 17 . . . cord-010092-uftc8inx 313 1 Our -PRON- PRP$ cord-010092-uftc8inx 313 2 data datum NNS cord-010092-uftc8inx 313 3 comparing compare VBG cord-010092-uftc8inx 313 4 the the DT cord-010092-uftc8inx 313 5 two two CD cord-010092-uftc8inx 313 6 different different JJ cord-010092-uftc8inx 313 7 HEV hev NN cord-010092-uftc8inx 313 8 screening screening NN cord-010092-uftc8inx 313 9 algorithms algorithm NNS cord-010092-uftc8inx 313 10 revealed reveal VBD cord-010092-uftc8inx 313 11 eight eight CD cord-010092-uftc8inx 313 12 HEV HEV NNP cord-010092-uftc8inx 313 13 RNA RNA NNP cord-010092-uftc8inx 313 14 positive positive JJ cord-010092-uftc8inx 313 15 donations donation NNS cord-010092-uftc8inx 313 16 using use VBG cord-010092-uftc8inx 313 17 a a DT cord-010092-uftc8inx 313 18 MP MP NNP cord-010092-uftc8inx 313 19 - - HYPH cord-010092-uftc8inx 313 20 NAT NAT NNP cord-010092-uftc8inx 313 21 ( ( -LRB- cord-010092-uftc8inx 313 22 incidence incidence NN cord-010092-uftc8inx 313 23 1:1,268 1:1,268 CD cord-010092-uftc8inx 313 24 ) ) -RRB- cord-010092-uftc8inx 313 25 , , , cord-010092-uftc8inx 313 26 whereas whereas IN cord-010092-uftc8inx 313 27 17 17 CD cord-010092-uftc8inx 313 28 HEV HEV NNP cord-010092-uftc8inx 313 29 RNA RNA NNP cord-010092-uftc8inx 313 30 positive positive JJ cord-010092-uftc8inx 313 31 donations donation NNS cord-010092-uftc8inx 313 32 were be VBD cord-010092-uftc8inx 313 33 identified identify VBN cord-010092-uftc8inx 313 34 by by IN cord-010092-uftc8inx 313 35 ID ID NNP cord-010092-uftc8inx 313 36 - - HYPH cord-010092-uftc8inx 313 37 NAT NAT NNP cord-010092-uftc8inx 313 38 ( ( -LRB- cord-010092-uftc8inx 313 39 incidence incidence NN cord-010092-uftc8inx 313 40 1:597 1:597 CD cord-010092-uftc8inx 313 41 ) ) -RRB- cord-010092-uftc8inx 313 42 ; ; : cord-010092-uftc8inx 313 43 all all DT cord-010092-uftc8inx 313 44 ID ID NNP cord-010092-uftc8inx 313 45 - - HYPH cord-010092-uftc8inx 313 46 NAT NAT NNP cord-010092-uftc8inx 313 47 only only RB cord-010092-uftc8inx 313 48 positive positive JJ cord-010092-uftc8inx 313 49 donations donation NNS cord-010092-uftc8inx 313 50 had have VBD cord-010092-uftc8inx 314 1 VL VL NNP cord-010092-uftc8inx 314 2 < < XX cord-010092-uftc8inx 314 3 25 25 CD cord-010092-uftc8inx 314 4 IU IU NNP cord-010092-uftc8inx 314 5 / / SYM cord-010092-uftc8inx 314 6 ml ml NN cord-010092-uftc8inx 314 7 . . . cord-010092-uftc8inx 315 1 Summary Summary NNP cord-010092-uftc8inx 315 2 / / SYM cord-010092-uftc8inx 315 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 315 4 : : : cord-010092-uftc8inx 316 1 Taken take VBN cord-010092-uftc8inx 316 2 into into IN cord-010092-uftc8inx 316 3 account account NN cord-010092-uftc8inx 316 4 the the DT cord-010092-uftc8inx 316 5 current current JJ cord-010092-uftc8inx 316 6 knowledge knowledge NN cord-010092-uftc8inx 316 7 on on IN cord-010092-uftc8inx 316 8 the the DT cord-010092-uftc8inx 316 9 required require VBN cord-010092-uftc8inx 316 10 MIFD MIFD NNP cord-010092-uftc8inx 316 11 , , , cord-010092-uftc8inx 316 12 the the DT cord-010092-uftc8inx 316 13 DIFD DIFD NNP cord-010092-uftc8inx 316 14 , , , cord-010092-uftc8inx 316 15 and and CC cord-010092-uftc8inx 316 16 the the DT cord-010092-uftc8inx 316 17 analytical analytical JJ cord-010092-uftc8inx 316 18 sensitivities sensitivity NNS cord-010092-uftc8inx 316 19 of of IN cord-010092-uftc8inx 316 20 the the DT cord-010092-uftc8inx 316 21 screening screening NN cord-010092-uftc8inx 316 22 methods method NNS cord-010092-uftc8inx 316 23 , , , cord-010092-uftc8inx 316 24 we -PRON- PRP cord-010092-uftc8inx 316 25 extrapolated extrapolate VBD cord-010092-uftc8inx 316 26 the the DT cord-010092-uftc8inx 316 27 detection detection NN cord-010092-uftc8inx 316 28 probability probability NN cord-010092-uftc8inx 316 29 of of IN cord-010092-uftc8inx 316 30 HEV HEV NNP cord-010092-uftc8inx 316 31 - - HYPH cord-010092-uftc8inx 316 32 RNA RNA NNP cord-010092-uftc8inx 316 33 positive positive JJ cord-010092-uftc8inx 316 34 blood blood NN cord-010092-uftc8inx 316 35 donors donor NNS cord-010092-uftc8inx 316 36 using use VBG cord-010092-uftc8inx 316 37 different different JJ cord-010092-uftc8inx 316 38 test test NN cord-010092-uftc8inx 316 39 strategies strategy NNS cord-010092-uftc8inx 316 40 ( ( -LRB- cord-010092-uftc8inx 316 41 NAT NAT NNP cord-010092-uftc8inx 316 42 assay assay NN cord-010092-uftc8inx 316 43 , , , cord-010092-uftc8inx 316 44 ID ID NNP cord-010092-uftc8inx 316 45 vs. vs. IN cord-010092-uftc8inx 316 46 minipool minipool NN cord-010092-uftc8inx 316 47 with with IN cord-010092-uftc8inx 316 48 different different JJ cord-010092-uftc8inx 316 49 pool pool NN cord-010092-uftc8inx 316 50 sizes size NNS cord-010092-uftc8inx 316 51 ) ) -RRB- cord-010092-uftc8inx 316 52 . . . cord-010092-uftc8inx 317 1 We -PRON- PRP cord-010092-uftc8inx 317 2 also also RB cord-010092-uftc8inx 317 3 considered consider VBD cord-010092-uftc8inx 317 4 the the DT cord-010092-uftc8inx 317 5 amount amount NN cord-010092-uftc8inx 317 6 of of IN cord-010092-uftc8inx 317 7 plasma plasma NN cord-010092-uftc8inx 317 8 in in IN cord-010092-uftc8inx 317 9 the the DT cord-010092-uftc8inx 317 10 different different JJ cord-010092-uftc8inx 317 11 blood blood NN cord-010092-uftc8inx 317 12 products product NNS cord-010092-uftc8inx 317 13 and and CC cord-010092-uftc8inx 317 14 calculated calculate VBD cord-010092-uftc8inx 317 15 the the DT cord-010092-uftc8inx 317 16 infectious infectious JJ cord-010092-uftc8inx 317 17 doses dose NNS cord-010092-uftc8inx 317 18 needed need VBN cord-010092-uftc8inx 317 19 to to TO cord-010092-uftc8inx 317 20 be be VB cord-010092-uftc8inx 317 21 detected detect VBN cord-010092-uftc8inx 317 22 . . . cord-010092-uftc8inx 318 1 Only only RB cord-010092-uftc8inx 318 2 ID ID NNP cord-010092-uftc8inx 318 3 testing testing NN cord-010092-uftc8inx 318 4 would would MD cord-010092-uftc8inx 318 5 be be VB cord-010092-uftc8inx 318 6 sufficient sufficient JJ cord-010092-uftc8inx 318 7 to to TO cord-010092-uftc8inx 318 8 detect detect VB cord-010092-uftc8inx 318 9 the the DT cord-010092-uftc8inx 318 10 minimum minimum JJ cord-010092-uftc8inx 318 11 VL vl NN cord-010092-uftc8inx 318 12 in in IN cord-010092-uftc8inx 318 13 the the DT cord-010092-uftc8inx 318 14 donor donor NN cord-010092-uftc8inx 318 15 to to TO cord-010092-uftc8inx 318 16 avoid avoid VB cord-010092-uftc8inx 318 17 TT TT NNP cord-010092-uftc8inx 318 18 - - HYPH cord-010092-uftc8inx 318 19 HEV HEV NNP cord-010092-uftc8inx 318 20 infections infection NNS cord-010092-uftc8inx 318 21 based base VBN cord-010092-uftc8inx 318 22 on on IN cord-010092-uftc8inx 318 23 the the DT cord-010092-uftc8inx 318 24 currently currently RB cord-010092-uftc8inx 318 25 known know VBN cord-010092-uftc8inx 318 26 MIFD MIFD NNP cord-010092-uftc8inx 318 27 , , , cord-010092-uftc8inx 318 28 but but CC cord-010092-uftc8inx 318 29 a a DT cord-010092-uftc8inx 318 30 highly highly RB cord-010092-uftc8inx 318 31 sensitive sensitive JJ cord-010092-uftc8inx 318 32 MP MP NNP cord-010092-uftc8inx 318 33 - - HYPH cord-010092-uftc8inx 318 34 NAT NAT NNP cord-010092-uftc8inx 318 35 should should MD cord-010092-uftc8inx 318 36 be be VB cord-010092-uftc8inx 318 37 adequate adequate JJ cord-010092-uftc8inx 318 38 as as IN cord-010092-uftc8inx 318 39 a a DT cord-010092-uftc8inx 318 40 routine routine JJ cord-010092-uftc8inx 318 41 screening screening NN cord-010092-uftc8inx 318 42 assay assay NN cord-010092-uftc8inx 318 43 to to TO cord-010092-uftc8inx 318 44 identify identify VB cord-010092-uftc8inx 318 45 high high JJ cord-010092-uftc8inx 318 46 viremic viremic JJ cord-010092-uftc8inx 318 47 donors donor NNS cord-010092-uftc8inx 318 48 and and CC cord-010092-uftc8inx 318 49 avoid avoid VB cord-010092-uftc8inx 318 50 TT TT NNP cord-010092-uftc8inx 318 51 - - HYPH cord-010092-uftc8inx 318 52 HEV HEV NNP cord-010092-uftc8inx 318 53 infections infection NNS cord-010092-uftc8inx 318 54 based base VBN cord-010092-uftc8inx 318 55 on on IN cord-010092-uftc8inx 318 56 the the DT cord-010092-uftc8inx 318 57 DIFD DIFD NNP cord-010092-uftc8inx 318 58 . . . cord-010092-uftc8inx 319 1 We -PRON- PRP cord-010092-uftc8inx 319 2 have have VBP cord-010092-uftc8inx 319 3 also also RB cord-010092-uftc8inx 319 4 determined determine VBN cord-010092-uftc8inx 319 5 that that IN cord-010092-uftc8inx 319 6 the the DT cord-010092-uftc8inx 319 7 incidence incidence NN cord-010092-uftc8inx 319 8 of of IN cord-010092-uftc8inx 319 9 HEV HEV NNP cord-010092-uftc8inx 319 10 infection infection NN cord-010092-uftc8inx 319 11 was be VBD cord-010092-uftc8inx 319 12 approximately approximately RB cord-010092-uftc8inx 319 13 50 50 CD cord-010092-uftc8inx 319 14 % % NN cord-010092-uftc8inx 319 15 higher high JJR cord-010092-uftc8inx 319 16 if if IN cord-010092-uftc8inx 319 17 ID ID NNP cord-010092-uftc8inx 319 18 - - HYPH cord-010092-uftc8inx 319 19 NAT NAT NNP cord-010092-uftc8inx 319 20 was be VBD cord-010092-uftc8inx 319 21 used use VBN cord-010092-uftc8inx 319 22 . . . cord-010092-uftc8inx 320 1 However however RB cord-010092-uftc8inx 320 2 , , , cord-010092-uftc8inx 320 3 VL VL NNP cord-010092-uftc8inx 320 4 were be VBD cord-010092-uftc8inx 320 5 below below IN cord-010092-uftc8inx 320 6 25 25 CD cord-010092-uftc8inx 320 7 IU IU NNP cord-010092-uftc8inx 320 8 / / SYM cord-010092-uftc8inx 320 9 ml ml NN cord-010092-uftc8inx 320 10 and and CC cord-010092-uftc8inx 320 11 will will MD cord-010092-uftc8inx 320 12 most most RBS cord-010092-uftc8inx 320 13 likely likely RB cord-010092-uftc8inx 320 14 not not RB cord-010092-uftc8inx 320 15 result result VB cord-010092-uftc8inx 320 16 in in IN cord-010092-uftc8inx 320 17 TT TT NNP cord-010092-uftc8inx 320 18 - - HYPH cord-010092-uftc8inx 320 19 HEV HEV NNP cord-010092-uftc8inx 320 20 infection infection NN cord-010092-uftc8inx 320 21 taken take VBN cord-010092-uftc8inx 320 22 into into IN cord-010092-uftc8inx 320 23 account account NN cord-010092-uftc8inx 320 24 the the DT cord-010092-uftc8inx 320 25 currently currently RB cord-010092-uftc8inx 320 26 known know VBN cord-010092-uftc8inx 320 27 MIFD MIFD NNP cord-010092-uftc8inx 320 28 or or CC cord-010092-uftc8inx 320 29 DIFD DIFD NNP cord-010092-uftc8inx 320 30 . . . cord-010092-uftc8inx 321 1 The the DT cord-010092-uftc8inx 321 2 clinical clinical JJ cord-010092-uftc8inx 321 3 relevance relevance NN cord-010092-uftc8inx 321 4 of of IN cord-010092-uftc8inx 321 5 and and CC cord-010092-uftc8inx 321 6 need need NN cord-010092-uftc8inx 321 7 of of IN cord-010092-uftc8inx 321 8 identification identification NN cord-010092-uftc8inx 321 9 of of IN cord-010092-uftc8inx 321 10 these these DT cord-010092-uftc8inx 321 11 low low JJ cord-010092-uftc8inx 321 12 level level NN cord-010092-uftc8inx 321 13 HEV HEV VBD cord-010092-uftc8inx 321 14 positive positive JJ cord-010092-uftc8inx 321 15 donors donor NNS cord-010092-uftc8inx 321 16 still still RB cord-010092-uftc8inx 321 17 require require VBP cord-010092-uftc8inx 321 18 further further JJ cord-010092-uftc8inx 321 19 investigation investigation NN cord-010092-uftc8inx 321 20 . . . cord-010092-uftc8inx 322 1 In in IN cord-010092-uftc8inx 322 2 the the DT cord-010092-uftc8inx 322 3 last last JJ cord-010092-uftc8inx 322 4 25 25 CD cord-010092-uftc8inx 322 5 years year NNS cord-010092-uftc8inx 322 6 several several JJ cord-010092-uftc8inx 322 7 pathogen pathogen NN cord-010092-uftc8inx 322 8 inactivation inactivation NN cord-010092-uftc8inx 322 9 ( ( -LRB- cord-010092-uftc8inx 322 10 PI PI NNP cord-010092-uftc8inx 322 11 ) ) -RRB- cord-010092-uftc8inx 322 12 technologies technology NNS cord-010092-uftc8inx 322 13 have have VBP cord-010092-uftc8inx 322 14 been be VBN cord-010092-uftc8inx 322 15 developed develop VBN cord-010092-uftc8inx 322 16 to to TO cord-010092-uftc8inx 322 17 be be VB cord-010092-uftc8inx 322 18 applied apply VBN cord-010092-uftc8inx 322 19 to to IN cord-010092-uftc8inx 322 20 blood blood NN cord-010092-uftc8inx 322 21 components component NNS cord-010092-uftc8inx 322 22 . . . cord-010092-uftc8inx 323 1 Technologies technology NNS cord-010092-uftc8inx 323 2 for for IN cord-010092-uftc8inx 323 3 inactivating inactivate VBG cord-010092-uftc8inx 323 4 pathogens pathogen NNS cord-010092-uftc8inx 323 5 in in IN cord-010092-uftc8inx 323 6 plasma plasma NN cord-010092-uftc8inx 323 7 and and CC cord-010092-uftc8inx 324 1 platelets platelet NNS cord-010092-uftc8inx 324 2 are be VBP cord-010092-uftc8inx 324 3 available available JJ cord-010092-uftc8inx 324 4 in in IN cord-010092-uftc8inx 324 5 the the DT cord-010092-uftc8inx 324 6 European European NNP cord-010092-uftc8inx 324 7 Union Union NNP cord-010092-uftc8inx 324 8 , , , cord-010092-uftc8inx 324 9 and and CC cord-010092-uftc8inx 324 10 some some DT cord-010092-uftc8inx 324 11 others other NNS cord-010092-uftc8inx 324 12 are be VBP cord-010092-uftc8inx 324 13 currently currently RB cord-010092-uftc8inx 324 14 under under IN cord-010092-uftc8inx 324 15 development development NN cord-010092-uftc8inx 324 16 . . . cord-010092-uftc8inx 325 1 The the DT cord-010092-uftc8inx 325 2 first first JJ cord-010092-uftc8inx 325 3 PI pi NN cord-010092-uftc8inx 325 4 technology technology NN cord-010092-uftc8inx 325 5 introduced introduce VBN cord-010092-uftc8inx 325 6 in in IN cord-010092-uftc8inx 325 7 the the DT cord-010092-uftc8inx 325 8 market market NN cord-010092-uftc8inx 325 9 was be VBD cord-010092-uftc8inx 325 10 for for IN cord-010092-uftc8inx 325 11 plasma plasma NN cord-010092-uftc8inx 325 12 , , , cord-010092-uftc8inx 325 13 and and CC cord-010092-uftc8inx 325 14 was be VBD cord-010092-uftc8inx 325 15 based base VBN cord-010092-uftc8inx 325 16 on on IN cord-010092-uftc8inx 325 17 the the DT cord-010092-uftc8inx 325 18 addition addition NN cord-010092-uftc8inx 325 19 of of IN cord-010092-uftc8inx 325 20 methylene methylene NN cord-010092-uftc8inx 325 21 blue blue JJ cord-010092-uftc8inx 325 22 and and CC cord-010092-uftc8inx 325 23 the the DT cord-010092-uftc8inx 325 24 illumination illumination NN cord-010092-uftc8inx 325 25 with with IN cord-010092-uftc8inx 325 26 light light NN cord-010092-uftc8inx 325 27 ( ( -LRB- cord-010092-uftc8inx 325 28 Theraflex Theraflex NNP cord-010092-uftc8inx 325 29 MB MB NNP cord-010092-uftc8inx 325 30 - - HYPH cord-010092-uftc8inx 325 31 Plasma Plasma NNP cord-010092-uftc8inx 325 32 , , , cord-010092-uftc8inx 325 33 MacoPharma MacoPharma NNP cord-010092-uftc8inx 325 34 and and CC cord-010092-uftc8inx 325 35 Gr Gr NNP cord-010092-uftc8inx 325 36 ıfols ıfol NNS cord-010092-uftc8inx 325 37 ) ) -RRB- cord-010092-uftc8inx 325 38 . . . cord-010092-uftc8inx 326 1 For for IN cord-010092-uftc8inx 326 2 platelets platelet NNS cord-010092-uftc8inx 326 3 and and CC cord-010092-uftc8inx 326 4 plasma plasma NN cord-010092-uftc8inx 326 5 two two CD cord-010092-uftc8inx 326 6 technologies technology NNS cord-010092-uftc8inx 326 7 are be VBP cord-010092-uftc8inx 326 8 licensed license VBN cord-010092-uftc8inx 326 9 , , , cord-010092-uftc8inx 326 10 one one CD cord-010092-uftc8inx 326 11 is be VBZ cord-010092-uftc8inx 326 12 based base VBN cord-010092-uftc8inx 326 13 on on IN cord-010092-uftc8inx 326 14 the the DT cord-010092-uftc8inx 326 15 addition addition NN cord-010092-uftc8inx 326 16 of of IN cord-010092-uftc8inx 326 17 amotosalen amotosalen NN cord-010092-uftc8inx 326 18 and and CC cord-010092-uftc8inx 326 19 the the DT cord-010092-uftc8inx 326 20 illumination illumination NN cord-010092-uftc8inx 326 21 with with IN cord-010092-uftc8inx 326 22 ultraviolet ultraviolet JJ cord-010092-uftc8inx 326 23 light light NN cord-010092-uftc8inx 326 24 ( ( -LRB- cord-010092-uftc8inx 326 25 UV uv NN cord-010092-uftc8inx 326 26 ) ) -RRB- cord-010092-uftc8inx 327 1 ( ( -LRB- cord-010092-uftc8inx 327 2 Intercept Intercept NNP cord-010092-uftc8inx 327 3 â â CD cord-010092-uftc8inx 327 4 , , , cord-010092-uftc8inx 327 5 Cerus Cerus NNP cord-010092-uftc8inx 327 6 ) ) -RRB- cord-010092-uftc8inx 327 7 and and CC cord-010092-uftc8inx 327 8 the the DT cord-010092-uftc8inx 327 9 other other JJ cord-010092-uftc8inx 327 10 one one NN cord-010092-uftc8inx 327 11 combines combine VBZ cord-010092-uftc8inx 327 12 the the DT cord-010092-uftc8inx 327 13 addition addition NN cord-010092-uftc8inx 327 14 of of IN cord-010092-uftc8inx 327 15 riboflavin riboflavin NN cord-010092-uftc8inx 327 16 ( ( -LRB- cord-010092-uftc8inx 327 17 vitamin vitamin NN cord-010092-uftc8inx 327 18 B b NN cord-010092-uftc8inx 327 19 2 2 CD cord-010092-uftc8inx 327 20 ) ) -RRB- cord-010092-uftc8inx 327 21 and and CC cord-010092-uftc8inx 327 22 the the DT cord-010092-uftc8inx 327 23 illumination illumination NN cord-010092-uftc8inx 327 24 with with IN cord-010092-uftc8inx 327 25 UV uv NN cord-010092-uftc8inx 327 26 light light NN cord-010092-uftc8inx 327 27 ( ( -LRB- cord-010092-uftc8inx 327 28 Mirasol Mirasol NNP cord-010092-uftc8inx 327 29 â â , cord-010092-uftc8inx 327 30 , , , cord-010092-uftc8inx 327 31 Terumo Terumo NNP cord-010092-uftc8inx 327 32 BCT BCT NNP cord-010092-uftc8inx 327 33 ) ) -RRB- cord-010092-uftc8inx 327 34 . . . cord-010092-uftc8inx 328 1 Currently currently RB cord-010092-uftc8inx 328 2 another another DT cord-010092-uftc8inx 328 3 technology technology NN cord-010092-uftc8inx 328 4 for for IN cord-010092-uftc8inx 328 5 platelet platelet NN cord-010092-uftc8inx 328 6 inactivation inactivation NN cord-010092-uftc8inx 328 7 , , , cord-010092-uftc8inx 328 8 based base VBN cord-010092-uftc8inx 328 9 on on IN cord-010092-uftc8inx 328 10 the the DT cord-010092-uftc8inx 328 11 illumination illumination NN cord-010092-uftc8inx 328 12 with with IN cord-010092-uftc8inx 328 13 UVC UVC NNP cord-010092-uftc8inx 328 14 light light NN cord-010092-uftc8inx 328 15 and and CC cord-010092-uftc8inx 328 16 strong strong JJ cord-010092-uftc8inx 328 17 agitation agitation NN cord-010092-uftc8inx 328 18 is be VBZ cord-010092-uftc8inx 328 19 under under IN cord-010092-uftc8inx 328 20 development development NN cord-010092-uftc8inx 328 21 ( ( -LRB- cord-010092-uftc8inx 328 22 Theraflex Theraflex NNP cord-010092-uftc8inx 328 23 , , , cord-010092-uftc8inx 328 24 MacoPharma MacoPharma NNP cord-010092-uftc8inx 328 25 ) ) -RRB- cord-010092-uftc8inx 328 26 . . . cord-010092-uftc8inx 329 1 For for IN cord-010092-uftc8inx 329 2 red red JJ cord-010092-uftc8inx 329 3 blood blood NN cord-010092-uftc8inx 329 4 cells cell NNS cord-010092-uftc8inx 329 5 one one CD cord-010092-uftc8inx 329 6 technology technology NN cord-010092-uftc8inx 329 7 based base VBN cord-010092-uftc8inx 329 8 on on IN cord-010092-uftc8inx 329 9 the the DT cord-010092-uftc8inx 329 10 addition addition NN cord-010092-uftc8inx 329 11 of of IN cord-010092-uftc8inx 329 12 one one CD cord-010092-uftc8inx 329 13 molecule molecule NN cord-010092-uftc8inx 329 14 ( ( -LRB- cord-010092-uftc8inx 329 15 amustaline amustaline NNP cord-010092-uftc8inx 329 16 , , , cord-010092-uftc8inx 329 17 Cerus Cerus NNP cord-010092-uftc8inx 329 18 ) ) -RRB- cord-010092-uftc8inx 329 19 is be VBZ cord-010092-uftc8inx 329 20 being be VBG cord-010092-uftc8inx 329 21 developed develop VBN cord-010092-uftc8inx 329 22 . . . cord-010092-uftc8inx 330 1 The the DT cord-010092-uftc8inx 330 2 mechanism mechanism NN cord-010092-uftc8inx 330 3 of of IN cord-010092-uftc8inx 330 4 action action NN cord-010092-uftc8inx 330 5 , , , cord-010092-uftc8inx 330 6 and and CC cord-010092-uftc8inx 330 7 the the DT cord-010092-uftc8inx 330 8 spectrum spectrum NN cord-010092-uftc8inx 330 9 and and CC cord-010092-uftc8inx 330 10 level level NN cord-010092-uftc8inx 330 11 of of IN cord-010092-uftc8inx 330 12 inactivation inactivation NN cord-010092-uftc8inx 330 13 of of IN cord-010092-uftc8inx 330 14 pathogens pathogen NNS cord-010092-uftc8inx 330 15 varies vary VBZ cord-010092-uftc8inx 330 16 among among IN cord-010092-uftc8inx 330 17 the the DT cord-010092-uftc8inx 330 18 different different JJ cord-010092-uftc8inx 330 19 technologies technology NNS cord-010092-uftc8inx 330 20 . . . cord-010092-uftc8inx 331 1 In in IN cord-010092-uftc8inx 331 2 addition addition NN cord-010092-uftc8inx 331 3 , , , cord-010092-uftc8inx 331 4 the the DT cord-010092-uftc8inx 331 5 number number NN cord-010092-uftc8inx 331 6 of of IN cord-010092-uftc8inx 331 7 studies study NNS cord-010092-uftc8inx 331 8 with with IN cord-010092-uftc8inx 331 9 clinically clinically RB cord-010092-uftc8inx 331 10 relevant relevant JJ cord-010092-uftc8inx 331 11 endpoints endpoint NNS cord-010092-uftc8inx 331 12 and and CC cord-010092-uftc8inx 331 13 the the DT cord-010092-uftc8inx 331 14 number number NN cord-010092-uftc8inx 331 15 of of IN cord-010092-uftc8inx 331 16 patients patient NNS cord-010092-uftc8inx 331 17 included include VBN cord-010092-uftc8inx 331 18 in in IN cord-010092-uftc8inx 331 19 the the DT cord-010092-uftc8inx 331 20 studies study NNS cord-010092-uftc8inx 331 21 is be VBZ cord-010092-uftc8inx 331 22 not not RB cord-010092-uftc8inx 331 23 homogeneous homogeneous JJ cord-010092-uftc8inx 331 24 . . . cord-010092-uftc8inx 332 1 There there EX cord-010092-uftc8inx 332 2 is be VBZ cord-010092-uftc8inx 332 3 published publish VBN cord-010092-uftc8inx 332 4 evidence evidence NN cord-010092-uftc8inx 332 5 for for IN cord-010092-uftc8inx 332 6 most most JJS cord-010092-uftc8inx 332 7 of of IN cord-010092-uftc8inx 332 8 them -PRON- PRP cord-010092-uftc8inx 332 9 that that WDT cord-010092-uftc8inx 332 10 show show VBP cord-010092-uftc8inx 332 11 that that IN cord-010092-uftc8inx 332 12 the the DT cord-010092-uftc8inx 332 13 treated treat VBN cord-010092-uftc8inx 332 14 blood blood NN cord-010092-uftc8inx 332 15 components component NNS cord-010092-uftc8inx 332 16 are be VBP cord-010092-uftc8inx 332 17 safe safe JJ cord-010092-uftc8inx 332 18 and and CC cord-010092-uftc8inx 332 19 efficacious efficacious JJ cord-010092-uftc8inx 332 20 for for IN cord-010092-uftc8inx 332 21 the the DT cord-010092-uftc8inx 332 22 patients patient NNS cord-010092-uftc8inx 332 23 although although IN cord-010092-uftc8inx 332 24 , , , cord-010092-uftc8inx 332 25 for for IN cord-010092-uftc8inx 332 26 treated treated JJ cord-010092-uftc8inx 332 27 platelet platelet NN cord-010092-uftc8inx 332 28 concentrates concentrate VBZ cord-010092-uftc8inx 332 29 some some DT cord-010092-uftc8inx 332 30 decrease decrease NN cord-010092-uftc8inx 332 31 in in IN cord-010092-uftc8inx 332 32 the the DT cord-010092-uftc8inx 332 33 posttransfusion posttransfusion NN cord-010092-uftc8inx 332 34 recovery recovery NN cord-010092-uftc8inx 332 35 and and CC cord-010092-uftc8inx 332 36 survival survival NN cord-010092-uftc8inx 332 37 of of IN cord-010092-uftc8inx 332 38 the the DT cord-010092-uftc8inx 332 39 transfused transfuse VBN cord-010092-uftc8inx 332 40 platelets platelet NNS cord-010092-uftc8inx 332 41 occur occur VBP cord-010092-uftc8inx 332 42 , , , cord-010092-uftc8inx 332 43 with with IN cord-010092-uftc8inx 332 44 differences difference NNS cord-010092-uftc8inx 332 45 between between IN cord-010092-uftc8inx 332 46 the the DT cord-010092-uftc8inx 332 47 different different JJ cord-010092-uftc8inx 332 48 technologies technology NNS cord-010092-uftc8inx 332 49 . . . cord-010092-uftc8inx 333 1 However however RB cord-010092-uftc8inx 333 2 , , , cord-010092-uftc8inx 333 3 cumulative cumulative JJ cord-010092-uftc8inx 333 4 experience experience NN cord-010092-uftc8inx 333 5 on on IN cord-010092-uftc8inx 333 6 the the DT cord-010092-uftc8inx 333 7 use use NN cord-010092-uftc8inx 333 8 in in IN cord-010092-uftc8inx 333 9 routine routine NN cord-010092-uftc8inx 333 10 , , , cord-010092-uftc8inx 333 11 for for IN cord-010092-uftc8inx 333 12 some some DT cord-010092-uftc8inx 333 13 of of IN cord-010092-uftc8inx 333 14 the the DT cord-010092-uftc8inx 333 15 technologies technology NNS cord-010092-uftc8inx 333 16 for for IN cord-010092-uftc8inx 333 17 almost almost RB cord-010092-uftc8inx 333 18 20 20 CD cord-010092-uftc8inx 333 19 years year NNS cord-010092-uftc8inx 333 20 , , , cord-010092-uftc8inx 333 21 support support VB cord-010092-uftc8inx 333 22 the the DT cord-010092-uftc8inx 333 23 concept concept NN cord-010092-uftc8inx 333 24 of of IN cord-010092-uftc8inx 333 25 the the DT cord-010092-uftc8inx 333 26 safety safety NN cord-010092-uftc8inx 333 27 and and CC cord-010092-uftc8inx 333 28 efficacy efficacy NN cord-010092-uftc8inx 333 29 of of IN cord-010092-uftc8inx 333 30 the the DT cord-010092-uftc8inx 333 31 blood blood NN cord-010092-uftc8inx 333 32 components component NNS cord-010092-uftc8inx 333 33 treated treat VBN cord-010092-uftc8inx 333 34 with with IN cord-010092-uftc8inx 333 35 pathogen pathogen NN cord-010092-uftc8inx 333 36 inactivation inactivation NN cord-010092-uftc8inx 333 37 technologies technology NNS cord-010092-uftc8inx 333 38 without without IN cord-010092-uftc8inx 333 39 a a DT cord-010092-uftc8inx 333 40 significant significant JJ cord-010092-uftc8inx 333 41 increase increase NN cord-010092-uftc8inx 333 42 in in IN cord-010092-uftc8inx 333 43 utilization utilization NN cord-010092-uftc8inx 333 44 . . . cord-010092-uftc8inx 334 1 The the DT cord-010092-uftc8inx 334 2 use use NN cord-010092-uftc8inx 334 3 of of IN cord-010092-uftc8inx 334 4 pathogen pathogen NN cord-010092-uftc8inx 334 5 inactivation inactivation NN cord-010092-uftc8inx 334 6 for for IN cord-010092-uftc8inx 334 7 blood blood NN cord-010092-uftc8inx 334 8 components component NNS cord-010092-uftc8inx 334 9 is be VBZ cord-010092-uftc8inx 334 10 not not RB cord-010092-uftc8inx 334 11 widespread widespread JJ cord-010092-uftc8inx 334 12 . . . cord-010092-uftc8inx 335 1 Differences difference NNS cord-010092-uftc8inx 335 2 in in IN cord-010092-uftc8inx 335 3 epidemiology epidemiology NN cord-010092-uftc8inx 335 4 between between IN cord-010092-uftc8inx 335 5 countries country NNS cord-010092-uftc8inx 335 6 , , , cord-010092-uftc8inx 335 7 infectious infectious JJ cord-010092-uftc8inx 335 8 risk risk NN cord-010092-uftc8inx 335 9 perception perception NN cord-010092-uftc8inx 335 10 , , , cord-010092-uftc8inx 335 11 concerns concern NNS cord-010092-uftc8inx 335 12 about about IN cord-010092-uftc8inx 335 13 potential potential JJ cord-010092-uftc8inx 335 14 adverse adverse JJ cord-010092-uftc8inx 335 15 effects effect NNS cord-010092-uftc8inx 335 16 associated associate VBN cord-010092-uftc8inx 335 17 with with IN cord-010092-uftc8inx 335 18 its -PRON- PRP$ cord-010092-uftc8inx 335 19 use use NN cord-010092-uftc8inx 335 20 and and CC cord-010092-uftc8inx 335 21 economical economical JJ cord-010092-uftc8inx 335 22 considerations consideration NNS cord-010092-uftc8inx 335 23 might may MD cord-010092-uftc8inx 335 24 explain explain VB cord-010092-uftc8inx 335 25 the the DT cord-010092-uftc8inx 335 26 differences difference NNS cord-010092-uftc8inx 335 27 observed observe VBN cord-010092-uftc8inx 335 28 in in IN cord-010092-uftc8inx 335 29 its -PRON- PRP$ cord-010092-uftc8inx 335 30 implementation implementation NN cord-010092-uftc8inx 335 31 . . . cord-010092-uftc8inx 336 1 The the DT cord-010092-uftc8inx 336 2 history history NN cord-010092-uftc8inx 336 3 of of IN cord-010092-uftc8inx 336 4 the the DT cord-010092-uftc8inx 336 5 P1 P1 NNP cord-010092-uftc8inx 336 6 and and CC cord-010092-uftc8inx 336 7 P p NN cord-010092-uftc8inx 336 8 k k NN cord-010092-uftc8inx 336 9 antigens antigen NNS cord-010092-uftc8inx 336 10 is be VBZ cord-010092-uftc8inx 336 11 complicated complicated JJ cord-010092-uftc8inx 336 12 and and CC cord-010092-uftc8inx 336 13 sometimes sometimes RB cord-010092-uftc8inx 336 14 confusing confusing JJ cord-010092-uftc8inx 336 15 because because IN cord-010092-uftc8inx 336 16 of of IN cord-010092-uftc8inx 336 17 several several JJ cord-010092-uftc8inx 336 18 changes change NNS cord-010092-uftc8inx 336 19 to to IN cord-010092-uftc8inx 336 20 the the DT cord-010092-uftc8inx 336 21 nomenclature nomenclature NN cord-010092-uftc8inx 336 22 . . . cord-010092-uftc8inx 337 1 The the DT cord-010092-uftc8inx 337 2 association association NN cord-010092-uftc8inx 337 3 between between IN cord-010092-uftc8inx 337 4 the the DT cord-010092-uftc8inx 337 5 antigens antigen NNS cord-010092-uftc8inx 337 6 and and CC cord-010092-uftc8inx 337 7 their -PRON- PRP$ cord-010092-uftc8inx 337 8 genetic genetic JJ cord-010092-uftc8inx 337 9 home home NN cord-010092-uftc8inx 337 10 has have VBZ cord-010092-uftc8inx 337 11 raised raise VBN cord-010092-uftc8inx 337 12 many many JJ cord-010092-uftc8inx 337 13 questions question NNS cord-010092-uftc8inx 337 14 as as RB cord-010092-uftc8inx 337 15 well well RB cord-010092-uftc8inx 337 16 as as IN cord-010092-uftc8inx 337 17 the the DT cord-010092-uftc8inx 337 18 longstanding longstanding JJ cord-010092-uftc8inx 337 19 enigma enigma NN cord-010092-uftc8inx 337 20 regarding regard VBG cord-010092-uftc8inx 337 21 the the DT cord-010092-uftc8inx 337 22 molecular molecular JJ cord-010092-uftc8inx 337 23 mechanism mechanism NN cord-010092-uftc8inx 337 24 underlying underlie VBG cord-010092-uftc8inx 337 25 the the DT cord-010092-uftc8inx 337 26 common common JJ cord-010092-uftc8inx 337 27 P p NN cord-010092-uftc8inx 337 28 1 1 CD cord-010092-uftc8inx 337 29 and and CC cord-010092-uftc8inx 337 30 P p NN cord-010092-uftc8inx 337 31 2 2 CD cord-010092-uftc8inx 337 32 phenotypes phenotype NNS cord-010092-uftc8inx 337 33 . . . cord-010092-uftc8inx 338 1 The the DT cord-010092-uftc8inx 338 2 system system NN cord-010092-uftc8inx 338 3 ( ( -LRB- cord-010092-uftc8inx 338 4 ISBT ISBT NNP cord-010092-uftc8inx 338 5 no no NN cord-010092-uftc8inx 338 6 . . . cord-010092-uftc8inx 338 7 003 003 LS cord-010092-uftc8inx 338 8 ) ) -RRB- cord-010092-uftc8inx 338 9 currently currently RB cord-010092-uftc8inx 338 10 includes include VBZ cord-010092-uftc8inx 338 11 three three CD cord-010092-uftc8inx 338 12 different different JJ cord-010092-uftc8inx 338 13 antigens antigen NNS cord-010092-uftc8inx 338 14 , , , cord-010092-uftc8inx 338 15 P1 P1 NNP cord-010092-uftc8inx 338 16 , , , cord-010092-uftc8inx 338 17 P p NN cord-010092-uftc8inx 338 18 k k NN cord-010092-uftc8inx 338 19 and and CC cord-010092-uftc8inx 338 20 NOR NOR NNP cord-010092-uftc8inx 338 21 . . . cord-010092-uftc8inx 339 1 The the DT cord-010092-uftc8inx 339 2 P1 P1 NNP cord-010092-uftc8inx 339 3 antigen antigen NN cord-010092-uftc8inx 339 4 was be VBD cord-010092-uftc8inx 339 5 discovered discover VBN cord-010092-uftc8inx 339 6 already already RB cord-010092-uftc8inx 339 7 in in IN cord-010092-uftc8inx 339 8 1927 1927 CD cord-010092-uftc8inx 339 9 by by IN cord-010092-uftc8inx 339 10 Landsteiner Landsteiner NNP cord-010092-uftc8inx 339 11 and and CC cord-010092-uftc8inx 339 12 Levine Levine NNP cord-010092-uftc8inx 339 13 while while IN cord-010092-uftc8inx 339 14 P p NN cord-010092-uftc8inx 339 15 k k NNP cord-010092-uftc8inx 339 16 and and CC cord-010092-uftc8inx 339 17 NOR nor CC cord-010092-uftc8inx 339 18 were be VBD cord-010092-uftc8inx 339 19 described describe VBN cord-010092-uftc8inx 339 20 in in IN cord-010092-uftc8inx 339 21 1951 1951 CD cord-010092-uftc8inx 339 22 and and CC cord-010092-uftc8inx 339 23 1982 1982 CD cord-010092-uftc8inx 339 24 , , , cord-010092-uftc8inx 339 25 respectively respectively RB cord-010092-uftc8inx 339 26 . . . cord-010092-uftc8inx 340 1 As as IN cord-010092-uftc8inx 340 2 for for IN cord-010092-uftc8inx 340 3 the the DT cord-010092-uftc8inx 340 4 ABO ABO NNP cord-010092-uftc8inx 340 5 system system NN cord-010092-uftc8inx 340 6 , , , cord-010092-uftc8inx 340 7 naturally naturally RB cord-010092-uftc8inx 340 8 - - HYPH cord-010092-uftc8inx 340 9 occurring occur VBG cord-010092-uftc8inx 340 10 antibodies antibody NNS cord-010092-uftc8inx 340 11 of of IN cord-010092-uftc8inx 340 12 IgM IgM NNP cord-010092-uftc8inx 340 13 and/or and/or CC cord-010092-uftc8inx 340 14 IgG IgG NNP cord-010092-uftc8inx 340 15 classes class NNS cord-010092-uftc8inx 340 16 can can MD cord-010092-uftc8inx 340 17 be be VB cord-010092-uftc8inx 340 18 formed form VBN cord-010092-uftc8inx 340 19 against against IN cord-010092-uftc8inx 340 20 the the DT cord-010092-uftc8inx 340 21 missing miss VBG cord-010092-uftc8inx 340 22 P1 P1 NNP cord-010092-uftc8inx 340 23 / / SYM cord-010092-uftc8inx 340 24 P p NN cord-010092-uftc8inx 340 25 k k NN cord-010092-uftc8inx 340 26 carbohydrate carbohydrate NN cord-010092-uftc8inx 340 27 structures structure NNS cord-010092-uftc8inx 340 28 . . . cord-010092-uftc8inx 341 1 Anti Anti NNP cord-010092-uftc8inx 341 2 - - NNP cord-010092-uftc8inx 341 3 P1 P1 NNP cord-010092-uftc8inx 341 4 is be VBZ cord-010092-uftc8inx 341 5 usually usually RB cord-010092-uftc8inx 341 6 a a DT cord-010092-uftc8inx 341 7 weak weak JJ cord-010092-uftc8inx 341 8 and and CC cord-010092-uftc8inx 341 9 cold cold JJ cord-010092-uftc8inx 341 10 - - HYPH cord-010092-uftc8inx 341 11 reactive reactive JJ cord-010092-uftc8inx 341 12 antibody antibody NN cord-010092-uftc8inx 341 13 very very RB cord-010092-uftc8inx 341 14 rarely rarely RB cord-010092-uftc8inx 341 15 implicated implicate VBN cord-010092-uftc8inx 341 16 in in IN cord-010092-uftc8inx 341 17 hemolytic hemolytic JJ cord-010092-uftc8inx 341 18 transfusion transfusion NN cord-010092-uftc8inx 341 19 reaction reaction NN cord-010092-uftc8inx 341 20 ( ( -LRB- cord-010092-uftc8inx 341 21 HTR HTR NNP cord-010092-uftc8inx 341 22 ) ) -RRB- cord-010092-uftc8inx 341 23 or or CC cord-010092-uftc8inx 341 24 hemolytic hemolytic JJ cord-010092-uftc8inx 341 25 disease disease NN cord-010092-uftc8inx 341 26 of of IN cord-010092-uftc8inx 341 27 the the DT cord-010092-uftc8inx 341 28 fetus fetus NN cord-010092-uftc8inx 341 29 and and CC cord-010092-uftc8inx 341 30 newborn newborn JJ cord-010092-uftc8inx 341 31 ( ( -LRB- cord-010092-uftc8inx 341 32 HDFN HDFN NNP cord-010092-uftc8inx 341 33 ) ) -RRB- cord-010092-uftc8inx 341 34 . . . cord-010092-uftc8inx 342 1 However however RB cord-010092-uftc8inx 342 2 , , , cord-010092-uftc8inx 342 3 some some DT cord-010092-uftc8inx 342 4 antibodies antibody NNS cord-010092-uftc8inx 342 5 against against IN cord-010092-uftc8inx 342 6 P1 P1 NNP cord-010092-uftc8inx 342 7 have have VBP cord-010092-uftc8inx 342 8 been be VBN cord-010092-uftc8inx 342 9 reported report VBN cord-010092-uftc8inx 342 10 to to TO cord-010092-uftc8inx 342 11 react react VB cord-010092-uftc8inx 342 12 at at IN cord-010092-uftc8inx 342 13 37 37 CD cord-010092-uftc8inx 342 14 ° ° NN cord-010092-uftc8inx 342 15 C c NN cord-010092-uftc8inx 342 16 , , , cord-010092-uftc8inx 342 17 bind bind VB cord-010092-uftc8inx 342 18 complement complement NN cord-010092-uftc8inx 342 19 and and CC cord-010092-uftc8inx 342 20 cause cause VB cord-010092-uftc8inx 342 21 both both DT cord-010092-uftc8inx 342 22 immediate immediate JJ cord-010092-uftc8inx 342 23 and and CC cord-010092-uftc8inx 342 24 delayed delayed JJ cord-010092-uftc8inx 342 25 HTRs htr NNS cord-010092-uftc8inx 342 26 . . . cord-010092-uftc8inx 343 1 The the DT cord-010092-uftc8inx 343 2 P p NN cord-010092-uftc8inx 343 3 k k NN cord-010092-uftc8inx 343 4 antibodies antibody NNS cord-010092-uftc8inx 343 5 can can MD cord-010092-uftc8inx 343 6 cause cause VB cord-010092-uftc8inx 343 7 HTR HTR NNP cord-010092-uftc8inx 343 8 and and CC cord-010092-uftc8inx 343 9 anti anti JJ cord-010092-uftc8inx 343 10 - - NN cord-010092-uftc8inx 343 11 NOR nor CC cord-010092-uftc8inx 343 12 is be VBZ cord-010092-uftc8inx 343 13 regarded regard VBN cord-010092-uftc8inx 343 14 as as IN cord-010092-uftc8inx 343 15 a a DT cord-010092-uftc8inx 343 16 polyagglutinin polyagglutinin NN cord-010092-uftc8inx 343 17 with with IN cord-010092-uftc8inx 343 18 unknown unknown JJ cord-010092-uftc8inx 343 19 clinical clinical JJ cord-010092-uftc8inx 343 20 significance significance NN cord-010092-uftc8inx 343 21 . . . cord-010092-uftc8inx 344 1 A a DT cord-010092-uftc8inx 344 2 higher high JJR cord-010092-uftc8inx 344 3 frequency frequency NN cord-010092-uftc8inx 344 4 of of IN cord-010092-uftc8inx 344 5 miscarriage miscarriage NN cord-010092-uftc8inx 344 6 is be VBZ cord-010092-uftc8inx 344 7 seen see VBN cord-010092-uftc8inx 344 8 in in IN cord-010092-uftc8inx 344 9 women woman NNS cord-010092-uftc8inx 344 10 with with IN cord-010092-uftc8inx 344 11 the the DT cord-010092-uftc8inx 344 12 rare rare JJ cord-010092-uftc8inx 344 13 phenotypes phenotype NNS cord-010092-uftc8inx 344 14 p p NN cord-010092-uftc8inx 344 15 and and CC cord-010092-uftc8inx 344 16 P p NN cord-010092-uftc8inx 345 1 1 1 CD cord-010092-uftc8inx 345 2 k k NNP cord-010092-uftc8inx 345 3 /P /P NNP cord-010092-uftc8inx 345 4 2 2 CD cord-010092-uftc8inx 345 5 k k NN cord-010092-uftc8inx 345 6 . . . cord-010092-uftc8inx 346 1 The the DT cord-010092-uftc8inx 346 2 RBC RBC NNP cord-010092-uftc8inx 346 3 of of IN cord-010092-uftc8inx 346 4 the the DT cord-010092-uftc8inx 346 5 fetus fetus NN cord-010092-uftc8inx 346 6 as as RB cord-010092-uftc8inx 346 7 well well RB cord-010092-uftc8inx 346 8 as as IN cord-010092-uftc8inx 346 9 of of IN cord-010092-uftc8inx 346 10 the the DT cord-010092-uftc8inx 346 11 newborn newborn JJ cord-010092-uftc8inx 346 12 express express JJ cord-010092-uftc8inx 346 13 low low JJ cord-010092-uftc8inx 346 14 amounts amount NNS cord-010092-uftc8inx 346 15 of of IN cord-010092-uftc8inx 346 16 P1 P1 NNP cord-010092-uftc8inx 346 17 , , , cord-010092-uftc8inx 346 18 P p NN cord-010092-uftc8inx 346 19 and and CC cord-010092-uftc8inx 346 20 P p NN cord-010092-uftc8inx 346 21 k k NN cord-010092-uftc8inx 346 22 antigens antigen NNS cord-010092-uftc8inx 346 23 but but CC cord-010092-uftc8inx 346 24 the the DT cord-010092-uftc8inx 346 25 placenta placenta NN cord-010092-uftc8inx 346 26 shows show VBZ cord-010092-uftc8inx 346 27 high high JJ cord-010092-uftc8inx 346 28 expression expression NN cord-010092-uftc8inx 346 29 and and CC cord-010092-uftc8inx 346 30 is be VBZ cord-010092-uftc8inx 346 31 consequently consequently RB cord-010092-uftc8inx 346 32 a a DT cord-010092-uftc8inx 346 33 possible possible JJ cord-010092-uftc8inx 346 34 target target NN cord-010092-uftc8inx 346 35 of of IN cord-010092-uftc8inx 346 36 the the DT cord-010092-uftc8inx 346 37 antibodies antibody NNS cord-010092-uftc8inx 346 38 and and CC cord-010092-uftc8inx 346 39 the the DT cord-010092-uftc8inx 346 40 cause cause NN cord-010092-uftc8inx 346 41 of of IN cord-010092-uftc8inx 346 42 the the DT cord-010092-uftc8inx 346 43 miscarriages miscarriage NNS cord-010092-uftc8inx 346 44 . . . cord-010092-uftc8inx 347 1 The the DT cord-010092-uftc8inx 347 2 P p NN cord-010092-uftc8inx 347 3 k k NN cord-010092-uftc8inx 347 4 and and CC cord-010092-uftc8inx 347 5 P1 P1 NNP cord-010092-uftc8inx 347 6 antigens antigen NNS cord-010092-uftc8inx 347 7 have have VBP cord-010092-uftc8inx 347 8 wide wide JJ cord-010092-uftc8inx 347 9 tissue tissue NN cord-010092-uftc8inx 347 10 distributions distribution NNS cord-010092-uftc8inx 347 11 and and CC cord-010092-uftc8inx 347 12 can can MD cord-010092-uftc8inx 347 13 act act VB cord-010092-uftc8inx 347 14 as as IN cord-010092-uftc8inx 347 15 host host NN cord-010092-uftc8inx 347 16 receptors receptor NNS cord-010092-uftc8inx 347 17 for for IN cord-010092-uftc8inx 347 18 various various JJ cord-010092-uftc8inx 347 19 pathogens pathogen NNS cord-010092-uftc8inx 347 20 and and CC cord-010092-uftc8inx 347 21 toxins toxin NNS cord-010092-uftc8inx 347 22 . . . cord-010092-uftc8inx 348 1 Furthermore furthermore RB cord-010092-uftc8inx 348 2 , , , cord-010092-uftc8inx 348 3 altered altered JJ cord-010092-uftc8inx 348 4 expression expression NN cord-010092-uftc8inx 348 5 of of IN cord-010092-uftc8inx 348 6 P p NN cord-010092-uftc8inx 348 7 k k NN cord-010092-uftc8inx 348 8 antigen antigen NN cord-010092-uftc8inx 348 9 has have VBZ cord-010092-uftc8inx 348 10 been be VBN cord-010092-uftc8inx 348 11 described describe VBN cord-010092-uftc8inx 348 12 in in IN cord-010092-uftc8inx 348 13 several several JJ cord-010092-uftc8inx 348 14 cancer cancer NN cord-010092-uftc8inx 348 15 forms form NNS cord-010092-uftc8inx 348 16 . . . cord-010092-uftc8inx 349 1 A a DT cord-010092-uftc8inx 349 2 longstanding longstanding JJ cord-010092-uftc8inx 349 3 question question NN cord-010092-uftc8inx 349 4 has have VBZ cord-010092-uftc8inx 349 5 been be VBN cord-010092-uftc8inx 349 6 why why WRB cord-010092-uftc8inx 349 7 individuals individual NNS cord-010092-uftc8inx 349 8 with with IN cord-010092-uftc8inx 349 9 p p NN cord-010092-uftc8inx 349 10 phenotype phenotype NN cord-010092-uftc8inx 349 11 not not RB cord-010092-uftc8inx 349 12 only only RB cord-010092-uftc8inx 349 13 lack lack NN cord-010092-uftc8inx 349 14 P p NN cord-010092-uftc8inx 349 15 k k NN cord-010092-uftc8inx 349 16 and and CC cord-010092-uftc8inx 349 17 P p NN cord-010092-uftc8inx 349 18 expression expression NN cord-010092-uftc8inx 349 19 but but CC cord-010092-uftc8inx 349 20 also also RB cord-010092-uftc8inx 349 21 P1 P1 NNP cord-010092-uftc8inx 349 22 . . . cord-010092-uftc8inx 350 1 Recently recently RB cord-010092-uftc8inx 350 2 it -PRON- PRP cord-010092-uftc8inx 350 3 was be VBD cord-010092-uftc8inx 350 4 clarified clarify VBN cord-010092-uftc8inx 350 5 that that IN cord-010092-uftc8inx 350 6 the the DT cord-010092-uftc8inx 350 7 same same JJ cord-010092-uftc8inx 350 8 A4GALTencoded a4galtencoded JJ cord-010092-uftc8inx 350 9 galactosyltransferase galactosyltransferase NN cord-010092-uftc8inx 350 10 synthesizes synthesize VBZ cord-010092-uftc8inx 350 11 both both CC cord-010092-uftc8inx 350 12 the the DT cord-010092-uftc8inx 350 13 P1 P1 NNP cord-010092-uftc8inx 350 14 , , , cord-010092-uftc8inx 350 15 P p NN cord-010092-uftc8inx 350 16 k k NN cord-010092-uftc8inx 350 17 and and CC cord-010092-uftc8inx 350 18 NOR nor CC cord-010092-uftc8inx 350 19 antigens antigen NNS cord-010092-uftc8inx 350 20 and and CC cord-010092-uftc8inx 350 21 in in IN cord-010092-uftc8inx 350 22 addition addition NN cord-010092-uftc8inx 350 23 the the DT cord-010092-uftc8inx 350 24 P p NN cord-010092-uftc8inx 350 25 1 1 CD cord-010092-uftc8inx 350 26 and and CC cord-010092-uftc8inx 350 27 P p NN cord-010092-uftc8inx 350 28 2 2 CD cord-010092-uftc8inx 350 29 phenotypes phenotype NNS cord-010092-uftc8inx 350 30 was be VBD cord-010092-uftc8inx 350 31 confirmed confirm VBN cord-010092-uftc8inx 350 32 to to TO cord-010092-uftc8inx 350 33 be be VB cord-010092-uftc8inx 350 34 caused cause VBN cord-010092-uftc8inx 350 35 by by IN cord-010092-uftc8inx 350 36 transcriptional transcriptional JJ cord-010092-uftc8inx 350 37 regulation regulation NN cord-010092-uftc8inx 350 38 . . . cord-010092-uftc8inx 351 1 Transcription transcription NN cord-010092-uftc8inx 351 2 factors factor NNS cord-010092-uftc8inx 351 3 bind bind VBP cord-010092-uftc8inx 351 4 selectively selectively RB cord-010092-uftc8inx 351 5 to to IN cord-010092-uftc8inx 351 6 the the DT cord-010092-uftc8inx 351 7 P p NN cord-010092-uftc8inx 351 8 1 1 CD cord-010092-uftc8inx 351 9 allele allele NN cord-010092-uftc8inx 351 10 in in IN cord-010092-uftc8inx 351 11 the the DT cord-010092-uftc8inx 351 12 5'-regulatory 5'-regulatory CD cord-010092-uftc8inx 351 13 region region NN cord-010092-uftc8inx 351 14 of of IN cord-010092-uftc8inx 351 15 A4GALT A4GALT NNP cord-010092-uftc8inx 351 16 , , , cord-010092-uftc8inx 351 17 which which WDT cord-010092-uftc8inx 351 18 enhance enhance VBP cord-010092-uftc8inx 351 19 transcription transcription NN cord-010092-uftc8inx 351 20 of of IN cord-010092-uftc8inx 351 21 the the DT cord-010092-uftc8inx 351 22 gene gene NN cord-010092-uftc8inx 351 23 . . . cord-010092-uftc8inx 352 1 It -PRON- PRP cord-010092-uftc8inx 352 2 has have VBZ cord-010092-uftc8inx 352 3 been be VBN cord-010092-uftc8inx 352 4 debated debate VBN cord-010092-uftc8inx 352 5 whether whether IN cord-010092-uftc8inx 352 6 the the DT cord-010092-uftc8inx 352 7 P p NN cord-010092-uftc8inx 352 8 k k NN cord-010092-uftc8inx 352 9 and and CC cord-010092-uftc8inx 352 10 P1 P1 NNP cord-010092-uftc8inx 352 11 antigens antigen NNS cord-010092-uftc8inx 352 12 exist exist VBP cord-010092-uftc8inx 352 13 on on IN cord-010092-uftc8inx 352 14 glycoproteins glycoprotein NNS cord-010092-uftc8inx 352 15 in in IN cord-010092-uftc8inx 352 16 the the DT cord-010092-uftc8inx 352 17 human human JJ cord-010092-uftc8inx 352 18 RBC RBC NNP cord-010092-uftc8inx 352 19 membrane membrane NN cord-010092-uftc8inx 352 20 or or CC cord-010092-uftc8inx 352 21 if if IN cord-010092-uftc8inx 352 22 glycolipids glycolipid NNS cord-010092-uftc8inx 352 23 are be VBP cord-010092-uftc8inx 352 24 the the DT cord-010092-uftc8inx 352 25 only only JJ cord-010092-uftc8inx 352 26 membrane membrane NN cord-010092-uftc8inx 352 27 components component NNS cord-010092-uftc8inx 352 28 carrying carry VBG cord-010092-uftc8inx 352 29 these these DT cord-010092-uftc8inx 352 30 epitopes epitope NNS cord-010092-uftc8inx 352 31 . . . cord-010092-uftc8inx 353 1 A a DT cord-010092-uftc8inx 353 2 recent recent JJ cord-010092-uftc8inx 353 3 publication publication NN cord-010092-uftc8inx 353 4 shows show VBZ cord-010092-uftc8inx 353 5 that that IN cord-010092-uftc8inx 353 6 the the DT cord-010092-uftc8inx 353 7 P1 P1 NNP cord-010092-uftc8inx 353 8 antigen antigen NN cord-010092-uftc8inx 353 9 can can MD cord-010092-uftc8inx 353 10 be be VB cord-010092-uftc8inx 353 11 detected detect VBN cord-010092-uftc8inx 353 12 on on IN cord-010092-uftc8inx 353 13 human human JJ cord-010092-uftc8inx 353 14 RBC RBC NNP cord-010092-uftc8inx 353 15 glycoproteins glycoprotein NNS cord-010092-uftc8inx 353 16 and and CC cord-010092-uftc8inx 353 17 thus thus RB cord-010092-uftc8inx 353 18 glycosphingolipids glycosphingolipids NNP cord-010092-uftc8inx 353 19 can can MD cord-010092-uftc8inx 353 20 no no RB cord-010092-uftc8inx 353 21 longer longer RB cord-010092-uftc8inx 353 22 be be VB cord-010092-uftc8inx 353 23 considered consider VBN cord-010092-uftc8inx 353 24 as as IN cord-010092-uftc8inx 353 25 the the DT cord-010092-uftc8inx 353 26 sole sole JJ cord-010092-uftc8inx 353 27 carriers carrier NNS cord-010092-uftc8inx 353 28 of of IN cord-010092-uftc8inx 353 29 the the DT cord-010092-uftc8inx 353 30 antigens antigen NNS cord-010092-uftc8inx 353 31 . . . cord-010092-uftc8inx 354 1 The the DT cord-010092-uftc8inx 354 2 blood blood NN cord-010092-uftc8inx 354 3 group group NN cord-010092-uftc8inx 354 4 system system NN cord-010092-uftc8inx 354 5 which which WDT cord-010092-uftc8inx 354 6 started start VBD cord-010092-uftc8inx 354 7 out out RP cord-010092-uftc8inx 354 8 with with IN cord-010092-uftc8inx 354 9 one one CD cord-010092-uftc8inx 354 10 antigen antigen NN cord-010092-uftc8inx 354 11 , , , cord-010092-uftc8inx 354 12 P1 P1 NNP cord-010092-uftc8inx 354 13 , , , cord-010092-uftc8inx 354 14 has have VBZ cord-010092-uftc8inx 354 15 now now RB cord-010092-uftc8inx 354 16 gained gain VBN cord-010092-uftc8inx 354 17 two two CD cord-010092-uftc8inx 354 18 more more JJR cord-010092-uftc8inx 354 19 members member NNS cord-010092-uftc8inx 354 20 namely namely RB cord-010092-uftc8inx 354 21 P p NN cord-010092-uftc8inx 354 22 k k NN cord-010092-uftc8inx 354 23 and and CC cord-010092-uftc8inx 354 24 NOR NOR NNP cord-010092-uftc8inx 354 25 . . . cord-010092-uftc8inx 355 1 Step step NN cord-010092-uftc8inx 355 2 by by IN cord-010092-uftc8inx 355 3 step step NN cord-010092-uftc8inx 355 4 the the DT cord-010092-uftc8inx 355 5 biochemical biochemical JJ cord-010092-uftc8inx 355 6 and and CC cord-010092-uftc8inx 355 7 genetic genetic JJ cord-010092-uftc8inx 355 8 basis basis NN cord-010092-uftc8inx 355 9 underlying underlie VBG cord-010092-uftc8inx 356 1 the the DT cord-010092-uftc8inx 356 2 antigens antigen NNS cord-010092-uftc8inx 356 3 expressed express VBN cord-010092-uftc8inx 356 4 in in IN cord-010092-uftc8inx 356 5 this this DT cord-010092-uftc8inx 356 6 system system NN cord-010092-uftc8inx 356 7 has have VBZ cord-010092-uftc8inx 356 8 been be VBN cord-010092-uftc8inx 356 9 revealed reveal VBN cord-010092-uftc8inx 356 10 but but CC cord-010092-uftc8inx 356 11 still still RB cord-010092-uftc8inx 356 12 many many JJ cord-010092-uftc8inx 356 13 questions question NNS cord-010092-uftc8inx 356 14 remain remain VBP cord-010092-uftc8inx 356 15 to to TO cord-010092-uftc8inx 356 16 be be VB cord-010092-uftc8inx 356 17 solved solve VBN cord-010092-uftc8inx 356 18 . . . cord-010092-uftc8inx 357 1 Neither neither CC cord-010092-uftc8inx 357 2 GATA1 gata1 XX cord-010092-uftc8inx 357 3 nor nor CC cord-010092-uftc8inx 357 4 KLF1 KLF1 NNP cord-010092-uftc8inx 357 5 represent represent VBP cord-010092-uftc8inx 357 6 a a DT cord-010092-uftc8inx 357 7 blood blood NN cord-010092-uftc8inx 357 8 group group NN cord-010092-uftc8inx 357 9 system system NN cord-010092-uftc8inx 357 10 but but CC cord-010092-uftc8inx 357 11 mutations mutation NNS cord-010092-uftc8inx 357 12 in in IN cord-010092-uftc8inx 357 13 the the DT cord-010092-uftc8inx 357 14 genes gene NNS cord-010092-uftc8inx 357 15 encoding encode VBG cord-010092-uftc8inx 357 16 these these DT cord-010092-uftc8inx 357 17 transcription transcription NN cord-010092-uftc8inx 357 18 factors factor NNS cord-010092-uftc8inx 357 19 ( ( -LRB- cord-010092-uftc8inx 357 20 TFs tf NNS cord-010092-uftc8inx 357 21 ) ) -RRB- cord-010092-uftc8inx 357 22 have have VBP cord-010092-uftc8inx 357 23 been be VBN cord-010092-uftc8inx 357 24 shown show VBN cord-010092-uftc8inx 357 25 to to TO cord-010092-uftc8inx 357 26 result result VB cord-010092-uftc8inx 357 27 in in IN cord-010092-uftc8inx 357 28 simultaneous simultaneous JJ cord-010092-uftc8inx 357 29 altered altered JJ cord-010092-uftc8inx 357 30 expression expression NN cord-010092-uftc8inx 357 31 of of IN cord-010092-uftc8inx 357 32 blood blood NN cord-010092-uftc8inx 357 33 group group NN cord-010092-uftc8inx 357 34 antigens antigen NNS cord-010092-uftc8inx 357 35 in in IN cord-010092-uftc8inx 357 36 certain certain JJ cord-010092-uftc8inx 357 37 rare rare JJ cord-010092-uftc8inx 357 38 blood blood NN cord-010092-uftc8inx 357 39 group group NN cord-010092-uftc8inx 357 40 phenotypes phenotype NNS cord-010092-uftc8inx 357 41 . . . cord-010092-uftc8inx 358 1 In in IN cord-010092-uftc8inx 358 2 particular particular JJ cord-010092-uftc8inx 358 3 , , , cord-010092-uftc8inx 358 4 mutations mutation NNS cord-010092-uftc8inx 358 5 in in IN cord-010092-uftc8inx 358 6 the the DT cord-010092-uftc8inx 358 7 KLF1 klf1 JJ cord-010092-uftc8inx 358 8 gene gene NN cord-010092-uftc8inx 358 9 are be VBP cord-010092-uftc8inx 358 10 responsible responsible JJ cord-010092-uftc8inx 358 11 for for IN cord-010092-uftc8inx 358 12 the the DT cord-010092-uftc8inx 358 13 dominantly dominantly RB cord-010092-uftc8inx 358 14 inherited inherit VBN cord-010092-uftc8inx 358 15 In(Lu In(Lu '' cord-010092-uftc8inx 358 16 ) ) -RRB- cord-010092-uftc8inx 358 17 phenotype phenotype NN cord-010092-uftc8inx 358 18 , , , cord-010092-uftc8inx 358 19 commonly commonly RB cord-010092-uftc8inx 358 20 referred refer VBD cord-010092-uftc8inx 358 21 to to IN cord-010092-uftc8inx 358 22 as as IN cord-010092-uftc8inx 358 23 Lu(a Lu(a NNP cord-010092-uftc8inx 358 24 - - HYPH cord-010092-uftc8inx 358 25 b- b- NNP cord-010092-uftc8inx 358 26 ) ) -RRB- cord-010092-uftc8inx 358 27 because because IN cord-010092-uftc8inx 358 28 of of IN cord-010092-uftc8inx 358 29 the the DT cord-010092-uftc8inx 358 30 gross gross JJ cord-010092-uftc8inx 358 31 reduction reduction NN cord-010092-uftc8inx 358 32 in in IN cord-010092-uftc8inx 358 33 Lutheran Lutheran NNP cord-010092-uftc8inx 358 34 antigens antigen NNS cord-010092-uftc8inx 358 35 expression expression NN cord-010092-uftc8inx 358 36 . . . cord-010092-uftc8inx 359 1 Red red JJ cord-010092-uftc8inx 359 2 cells cell NNS cord-010092-uftc8inx 359 3 from from IN cord-010092-uftc8inx 359 4 In(Lu In(Lu '' cord-010092-uftc8inx 359 5 ) ) -RRB- cord-010092-uftc8inx 360 1 individuals individual NNS cord-010092-uftc8inx 360 2 , , , cord-010092-uftc8inx 360 3 though though RB cord-010092-uftc8inx 360 4 , , , cord-010092-uftc8inx 360 5 have have VBP cord-010092-uftc8inx 360 6 also also RB cord-010092-uftc8inx 360 7 weakened weaken VBN cord-010092-uftc8inx 360 8 expression expression NN cord-010092-uftc8inx 360 9 of of IN cord-010092-uftc8inx 360 10 other other JJ cord-010092-uftc8inx 360 11 blood blood NN cord-010092-uftc8inx 360 12 group group NN cord-010092-uftc8inx 360 13 antigens antigen NNS cord-010092-uftc8inx 360 14 , , , cord-010092-uftc8inx 360 15 like like IN cord-010092-uftc8inx 360 16 the the DT cord-010092-uftc8inx 360 17 high high JJ cord-010092-uftc8inx 360 18 - - HYPH cord-010092-uftc8inx 360 19 incidence incidence NN cord-010092-uftc8inx 360 20 antigen antigen NN cord-010092-uftc8inx 360 21 AnWj AnWj NNP cord-010092-uftc8inx 360 22 , , , cord-010092-uftc8inx 360 23 the the DT cord-010092-uftc8inx 360 24 antigens antigen NNS cord-010092-uftc8inx 360 25 of of IN cord-010092-uftc8inx 360 26 the the DT cord-010092-uftc8inx 360 27 Indian indian JJ cord-010092-uftc8inx 360 28 blood blood NN cord-010092-uftc8inx 360 29 group group NN cord-010092-uftc8inx 360 30 system system NN cord-010092-uftc8inx 360 31 ( ( -LRB- cord-010092-uftc8inx 360 32 CD44 CD44 NNP cord-010092-uftc8inx 360 33 ) ) -RRB- cord-010092-uftc8inx 360 34 and and CC cord-010092-uftc8inx 360 35 P1 P1 NNP cord-010092-uftc8inx 360 36 , , , cord-010092-uftc8inx 360 37 among among IN cord-010092-uftc8inx 360 38 others other NNS cord-010092-uftc8inx 360 39 . . . cord-010092-uftc8inx 361 1 Since since IN cord-010092-uftc8inx 361 2 the the DT cord-010092-uftc8inx 361 3 first first JJ cord-010092-uftc8inx 361 4 description description NN cord-010092-uftc8inx 361 5 of of IN cord-010092-uftc8inx 361 6 KLF1 klf1 JJ cord-010092-uftc8inx 361 7 variants variant NNS cord-010092-uftc8inx 361 8 associated associate VBN cord-010092-uftc8inx 361 9 with with IN cord-010092-uftc8inx 361 10 the the DT cord-010092-uftc8inx 361 11 In(Lu In(Lu NNP cord-010092-uftc8inx 361 12 ) ) -RRB- cord-010092-uftc8inx 361 13 phenotype phenotype NN cord-010092-uftc8inx 361 14 , , , cord-010092-uftc8inx 361 15 many many JJ cord-010092-uftc8inx 361 16 other other JJ cord-010092-uftc8inx 361 17 variants variant NNS cord-010092-uftc8inx 361 18 of of IN cord-010092-uftc8inx 361 19 this this DT cord-010092-uftc8inx 361 20 gene gene NN cord-010092-uftc8inx 361 21 have have VBP cord-010092-uftc8inx 361 22 been be VBN cord-010092-uftc8inx 361 23 reported report VBN cord-010092-uftc8inx 361 24 with with IN cord-010092-uftc8inx 361 25 an an DT cord-010092-uftc8inx 361 26 impact impact NN cord-010092-uftc8inx 361 27 on on IN cord-010092-uftc8inx 361 28 blood blood NN cord-010092-uftc8inx 361 29 group group NN cord-010092-uftc8inx 361 30 antigen antigen NN cord-010092-uftc8inx 361 31 expression expression NN cord-010092-uftc8inx 361 32 and and CC cord-010092-uftc8inx 361 33 they -PRON- PRP cord-010092-uftc8inx 361 34 are be VBP cord-010092-uftc8inx 361 35 listed list VBN cord-010092-uftc8inx 361 36 on on IN cord-010092-uftc8inx 361 37 the the DT cord-010092-uftc8inx 361 38 KLF1 klf1 JJ cord-010092-uftc8inx 361 39 Table Table NNP cord-010092-uftc8inx 361 40 of of IN cord-010092-uftc8inx 361 41 Blood Blood NNP cord-010092-uftc8inx 361 42 Group Group NNP cord-010092-uftc8inx 361 43 Alleles Alleles NNP cord-010092-uftc8inx 361 44 . . . cord-010092-uftc8inx 362 1 Other other JJ cord-010092-uftc8inx 362 2 than than IN cord-010092-uftc8inx 362 3 KLF1 KLF1 NNP cord-010092-uftc8inx 362 4 , , , cord-010092-uftc8inx 362 5 a a DT cord-010092-uftc8inx 362 6 mutated mutate VBN cord-010092-uftc8inx 362 7 GATA1 GATA1 NNP cord-010092-uftc8inx 362 8 gene gene NN cord-010092-uftc8inx 362 9 has have VBZ cord-010092-uftc8inx 362 10 also also RB cord-010092-uftc8inx 362 11 been be VBN cord-010092-uftc8inx 362 12 found find VBN cord-010092-uftc8inx 362 13 associated associate VBN cord-010092-uftc8inx 362 14 with with IN cord-010092-uftc8inx 362 15 the the DT cord-010092-uftc8inx 362 16 X x NN cord-010092-uftc8inx 362 17 - - HYPH cord-010092-uftc8inx 362 18 linked link VBN cord-010092-uftc8inx 362 19 form form NN cord-010092-uftc8inx 362 20 of of IN cord-010092-uftc8inx 362 21 the the DT cord-010092-uftc8inx 362 22 Lutheran Lutheran NNP cord-010092-uftc8inx 362 23 - - HYPH cord-010092-uftc8inx 362 24 mod mod NN cord-010092-uftc8inx 362 25 phenotype phenotype NN cord-010092-uftc8inx 362 26 and and CC cord-010092-uftc8inx 362 27 has have VBZ cord-010092-uftc8inx 362 28 likewise likewise RB cord-010092-uftc8inx 362 29 been be VBN cord-010092-uftc8inx 362 30 registered register VBN cord-010092-uftc8inx 362 31 in in IN cord-010092-uftc8inx 362 32 the the DT cord-010092-uftc8inx 362 33 GATA1 gata1 XX cord-010092-uftc8inx 363 1 Allele Allele NNP cord-010092-uftc8inx 363 2 Table Table NNP cord-010092-uftc8inx 363 3 . . . cord-010092-uftc8inx 364 1 Besides besides IN cord-010092-uftc8inx 364 2 the the DT cord-010092-uftc8inx 364 3 effect effect NN cord-010092-uftc8inx 364 4 of of IN cord-010092-uftc8inx 364 5 TF TF NNP cord-010092-uftc8inx 364 6 variants variant NNS cord-010092-uftc8inx 364 7 on on IN cord-010092-uftc8inx 364 8 blood blood NN cord-010092-uftc8inx 364 9 group group NN cord-010092-uftc8inx 364 10 antigen antigen NN cord-010092-uftc8inx 364 11 expression expression NN cord-010092-uftc8inx 364 12 , , , cord-010092-uftc8inx 364 13 there there EX cord-010092-uftc8inx 364 14 are be VBP cord-010092-uftc8inx 364 15 transcription transcription NN cord-010092-uftc8inx 364 16 factor factor NN cord-010092-uftc8inx 364 17 - - HYPH cord-010092-uftc8inx 364 18 binding bind VBG cord-010092-uftc8inx 364 19 site site NN cord-010092-uftc8inx 364 20 polymorphisms polymorphism NNS cord-010092-uftc8inx 364 21 in in IN cord-010092-uftc8inx 364 22 regulatory regulatory JJ cord-010092-uftc8inx 364 23 regions region NNS cord-010092-uftc8inx 364 24 of of IN cord-010092-uftc8inx 364 25 blood blood NN cord-010092-uftc8inx 364 26 group group NN cord-010092-uftc8inx 364 27 genes gene NNS cord-010092-uftc8inx 364 28 , , , cord-010092-uftc8inx 364 29 which which WDT cord-010092-uftc8inx 364 30 also also RB cord-010092-uftc8inx 364 31 have have VBP cord-010092-uftc8inx 364 32 an an DT cord-010092-uftc8inx 364 33 impact impact NN cord-010092-uftc8inx 364 34 on on IN cord-010092-uftc8inx 364 35 the the DT cord-010092-uftc8inx 364 36 expression expression NN cord-010092-uftc8inx 364 37 of of IN cord-010092-uftc8inx 364 38 the the DT cord-010092-uftc8inx 364 39 encoded encode VBN cord-010092-uftc8inx 364 40 antigens antigen NNS cord-010092-uftc8inx 364 41 in in IN cord-010092-uftc8inx 364 42 red red JJ cord-010092-uftc8inx 364 43 cells cell NNS cord-010092-uftc8inx 364 44 . . . cord-010092-uftc8inx 365 1 The the DT cord-010092-uftc8inx 365 2 first first JJ cord-010092-uftc8inx 365 3 example example NN cord-010092-uftc8inx 365 4 of of IN cord-010092-uftc8inx 365 5 such such JJ cord-010092-uftc8inx 365 6 type type NN cord-010092-uftc8inx 365 7 of of IN cord-010092-uftc8inx 365 8 polymorphisms polymorphism NNS cord-010092-uftc8inx 365 9 was be VBD cord-010092-uftc8inx 365 10 described describe VBN cord-010092-uftc8inx 365 11 in in IN cord-010092-uftc8inx 365 12 1995 1995 CD cord-010092-uftc8inx 365 13 , , , cord-010092-uftc8inx 365 14 when when WRB cord-010092-uftc8inx 365 15 the the DT cord-010092-uftc8inx 365 16 disruption disruption NN cord-010092-uftc8inx 365 17 of of IN cord-010092-uftc8inx 365 18 a a DT cord-010092-uftc8inx 365 19 GATA GATA NNP cord-010092-uftc8inx 365 20 motif motif NN cord-010092-uftc8inx 365 21 in in IN cord-010092-uftc8inx 365 22 the the DT cord-010092-uftc8inx 365 23 ACKR1 ACKR1 NNP cord-010092-uftc8inx 365 24 gene gene NN cord-010092-uftc8inx 365 25 promoter promoter NN cord-010092-uftc8inx 365 26 was be VBD cord-010092-uftc8inx 365 27 found find VBN cord-010092-uftc8inx 365 28 to to TO cord-010092-uftc8inx 365 29 abolish abolish VB cord-010092-uftc8inx 365 30 erythroid erythroid JJ cord-010092-uftc8inx 365 31 gene gene NN cord-010092-uftc8inx 365 32 expression expression NN cord-010092-uftc8inx 365 33 in in IN cord-010092-uftc8inx 365 34 Fy(a Fy(a NNP cord-010092-uftc8inx 365 35 - - HYPH cord-010092-uftc8inx 365 36 b- b- NNP cord-010092-uftc8inx 366 1 ) ) -RRB- cord-010092-uftc8inx 367 1 individuals individual NNS cord-010092-uftc8inx 367 2 of of IN cord-010092-uftc8inx 367 3 African african JJ cord-010092-uftc8inx 367 4 descent descent NN cord-010092-uftc8inx 367 5 . . . cord-010092-uftc8inx 368 1 The the DT cord-010092-uftc8inx 368 2 impact impact NN cord-010092-uftc8inx 368 3 of of IN cord-010092-uftc8inx 368 4 mutations mutation NNS cord-010092-uftc8inx 368 5 affecting affect VBG cord-010092-uftc8inx 368 6 GATA1 gata1 NN cord-010092-uftc8inx 368 7 binding bind VBG cord-010092-uftc8inx 368 8 sites site NNS cord-010092-uftc8inx 368 9 has have VBZ cord-010092-uftc8inx 368 10 also also RB cord-010092-uftc8inx 368 11 been be VBN cord-010092-uftc8inx 368 12 described describe VBN cord-010092-uftc8inx 368 13 in in IN cord-010092-uftc8inx 368 14 some some DT cord-010092-uftc8inx 368 15 ABO ABO NNP cord-010092-uftc8inx 368 16 subgroups subgroup NNS cord-010092-uftc8inx 368 17 , , , cord-010092-uftc8inx 368 18 like like IN cord-010092-uftc8inx 368 19 the the DT cord-010092-uftc8inx 368 20 Am Am NNP cord-010092-uftc8inx 368 21 and and CC cord-010092-uftc8inx 368 22 Bm Bm NNP cord-010092-uftc8inx 368 23 phenotypes phenotype NNS cord-010092-uftc8inx 368 24 . . . cord-010092-uftc8inx 369 1 A a DT cord-010092-uftc8inx 369 2 regulatory regulatory JJ cord-010092-uftc8inx 369 3 element element NN cord-010092-uftc8inx 369 4 with with IN cord-010092-uftc8inx 369 5 GATA GATA NNP cord-010092-uftc8inx 369 6 binding bind VBG cord-010092-uftc8inx 369 7 sites site NNS cord-010092-uftc8inx 369 8 in in IN cord-010092-uftc8inx 369 9 the the DT cord-010092-uftc8inx 369 10 first first JJ cord-010092-uftc8inx 369 11 intron intron NN cord-010092-uftc8inx 369 12 of of IN cord-010092-uftc8inx 369 13 the the DT cord-010092-uftc8inx 369 14 ABO ABO NNP cord-010092-uftc8inx 369 15 gene gene NN cord-010092-uftc8inx 369 16 has have VBZ cord-010092-uftc8inx 369 17 been be VBN cord-010092-uftc8inx 369 18 found find VBN cord-010092-uftc8inx 369 19 to to TO cord-010092-uftc8inx 369 20 be be VB cord-010092-uftc8inx 369 21 altered alter VBN cord-010092-uftc8inx 369 22 in in IN cord-010092-uftc8inx 369 23 individuals individual NNS cord-010092-uftc8inx 369 24 with with IN cord-010092-uftc8inx 369 25 these these DT cord-010092-uftc8inx 369 26 phenotypes phenotype NNS cord-010092-uftc8inx 369 27 , , , cord-010092-uftc8inx 369 28 either either CC cord-010092-uftc8inx 369 29 by by IN cord-010092-uftc8inx 369 30 deletion deletion NN cord-010092-uftc8inx 369 31 or or CC cord-010092-uftc8inx 369 32 by by IN cord-010092-uftc8inx 369 33 a a DT cord-010092-uftc8inx 369 34 point point NN cord-010092-uftc8inx 369 35 mutation mutation NN cord-010092-uftc8inx 369 36 disrupting disrupt VBG cord-010092-uftc8inx 369 37 the the DT cord-010092-uftc8inx 369 38 GATA GATA NNP cord-010092-uftc8inx 369 39 motif motif NN cord-010092-uftc8inx 369 40 . . . cord-010092-uftc8inx 370 1 Recent recent JJ cord-010092-uftc8inx 370 2 findings finding NNS cord-010092-uftc8inx 370 3 have have VBP cord-010092-uftc8inx 370 4 also also RB cord-010092-uftc8inx 370 5 revealed reveal VBN cord-010092-uftc8inx 370 6 that that IN cord-010092-uftc8inx 370 7 Xga Xga NNP cord-010092-uftc8inx 370 8 expression expression NN cord-010092-uftc8inx 370 9 on on IN cord-010092-uftc8inx 370 10 red red JJ cord-010092-uftc8inx 370 11 cells cell NNS cord-010092-uftc8inx 370 12 is be VBZ cord-010092-uftc8inx 370 13 dependent dependent JJ cord-010092-uftc8inx 370 14 on on IN cord-010092-uftc8inx 370 15 GATA1 GATA1 NNS cord-010092-uftc8inx 370 16 binding bind VBG cord-010092-uftc8inx 370 17 to to IN cord-010092-uftc8inx 370 18 a a DT cord-010092-uftc8inx 370 19 control control NN cord-010092-uftc8inx 370 20 element element NN cord-010092-uftc8inx 370 21 located locate VBN cord-010092-uftc8inx 370 22 3.7 3.7 CD cord-010092-uftc8inx 370 23 kb kb NNS cord-010092-uftc8inx 370 24 upstream upstream RB cord-010092-uftc8inx 370 25 of of IN cord-010092-uftc8inx 370 26 the the DT cord-010092-uftc8inx 370 27 XG XG NNP cord-010092-uftc8inx 370 28 gene gene NN cord-010092-uftc8inx 370 29 . . . cord-010092-uftc8inx 371 1 A a DT cord-010092-uftc8inx 371 2 single single JJ cord-010092-uftc8inx 371 3 nucleotide nucleotide JJ cord-010092-uftc8inx 371 4 polymorphism polymorphism NN cord-010092-uftc8inx 371 5 ( ( -LRB- cord-010092-uftc8inx 371 6 SNP SNP NNP cord-010092-uftc8inx 371 7 ) ) -RRB- cord-010092-uftc8inx 371 8 within within IN cord-010092-uftc8inx 371 9 this this DT cord-010092-uftc8inx 371 10 region region NN cord-010092-uftc8inx 371 11 was be VBD cord-010092-uftc8inx 371 12 shown show VBN cord-010092-uftc8inx 371 13 to to TO cord-010092-uftc8inx 371 14 correlate correlate VB cord-010092-uftc8inx 371 15 very very RB cord-010092-uftc8inx 371 16 well well RB cord-010092-uftc8inx 371 17 with with IN cord-010092-uftc8inx 371 18 the the DT cord-010092-uftc8inx 371 19 expected expect VBN cord-010092-uftc8inx 371 20 distribution distribution NN cord-010092-uftc8inx 371 21 of of IN cord-010092-uftc8inx 371 22 the the DT cord-010092-uftc8inx 371 23 Xga Xga NNP cord-010092-uftc8inx 371 24 negative negative JJ cord-010092-uftc8inx 371 25 phenotype phenotype NN cord-010092-uftc8inx 371 26 in in IN cord-010092-uftc8inx 371 27 different different JJ cord-010092-uftc8inx 371 28 populations population NNS cord-010092-uftc8inx 371 29 . . . cord-010092-uftc8inx 372 1 Further further JJ cord-010092-uftc8inx 372 2 work work NN cord-010092-uftc8inx 372 3 has have VBZ cord-010092-uftc8inx 372 4 demonstrated demonstrate VBN cord-010092-uftc8inx 372 5 that that IN cord-010092-uftc8inx 372 6 this this DT cord-010092-uftc8inx 372 7 G g NN cord-010092-uftc8inx 372 8 > > XX cord-010092-uftc8inx 372 9 C c NN cord-010092-uftc8inx 372 10 SNP SNP NNP cord-010092-uftc8inx 372 11 disrupts disrupt VBZ cord-010092-uftc8inx 372 12 a a DT cord-010092-uftc8inx 372 13 GATA1 GATA1 NNP cord-010092-uftc8inx 372 14 binding binding NN cord-010092-uftc8inx 372 15 site site NN cord-010092-uftc8inx 372 16 and and CC cord-010092-uftc8inx 372 17 consequently consequently RB cord-010092-uftc8inx 372 18 abolishes abolish VBZ cord-010092-uftc8inx 372 19 erythrocyte erythrocyte NN cord-010092-uftc8inx 372 20 Xg Xg NNP cord-010092-uftc8inx 372 21 expression expression NN cord-010092-uftc8inx 372 22 . . . cord-010092-uftc8inx 373 1 Overall overall RB cord-010092-uftc8inx 373 2 , , , cord-010092-uftc8inx 373 3 these these DT cord-010092-uftc8inx 373 4 investigations investigation NNS cord-010092-uftc8inx 373 5 have have VBP cord-010092-uftc8inx 373 6 allowed allow VBN cord-010092-uftc8inx 373 7 to to TO cord-010092-uftc8inx 373 8 elucidate elucidate VB cord-010092-uftc8inx 373 9 the the DT cord-010092-uftc8inx 373 10 underlying underlying JJ cord-010092-uftc8inx 373 11 genetic genetic JJ cord-010092-uftc8inx 373 12 basis basis NN cord-010092-uftc8inx 373 13 for for IN cord-010092-uftc8inx 373 14 Xga Xga NNP cord-010092-uftc8inx 373 15 expression expression NN cord-010092-uftc8inx 373 16 and and CC cord-010092-uftc8inx 373 17 have have VBP cord-010092-uftc8inx 373 18 made make VBN cord-010092-uftc8inx 373 19 Xga Xga NNP cord-010092-uftc8inx 373 20 genotyping genotyping NN cord-010092-uftc8inx 373 21 possible possible JJ cord-010092-uftc8inx 373 22 . . . cord-010092-uftc8inx 374 1 Similar similar JJ cord-010092-uftc8inx 374 2 to to IN cord-010092-uftc8inx 374 3 Xga Xga NNP cord-010092-uftc8inx 374 4 , , , cord-010092-uftc8inx 374 5 the the DT cord-010092-uftc8inx 374 6 P1 P1 NNP cord-010092-uftc8inx 374 7 antigen antigen NN cord-010092-uftc8inx 374 8 has have VBZ cord-010092-uftc8inx 374 9 been be VBN cord-010092-uftc8inx 374 10 known know VBN cord-010092-uftc8inx 374 11 for for IN cord-010092-uftc8inx 374 12 a a DT cord-010092-uftc8inx 374 13 long long JJ cord-010092-uftc8inx 374 14 time time NN cord-010092-uftc8inx 374 15 to to TO cord-010092-uftc8inx 374 16 be be VB cord-010092-uftc8inx 374 17 determined determine VBN cord-010092-uftc8inx 374 18 by by IN cord-010092-uftc8inx 374 19 the the DT cord-010092-uftc8inx 374 20 A4GALT A4GALT NNP cord-010092-uftc8inx 374 21 gene gene NN cord-010092-uftc8inx 374 22 but but CC cord-010092-uftc8inx 374 23 the the DT cord-010092-uftc8inx 374 24 molecular molecular JJ cord-010092-uftc8inx 374 25 basis basis NN cord-010092-uftc8inx 374 26 underlying underlie VBG cord-010092-uftc8inx 374 27 the the DT cord-010092-uftc8inx 374 28 common common JJ cord-010092-uftc8inx 374 29 P1 P1 NNP cord-010092-uftc8inx 374 30 / / SYM cord-010092-uftc8inx 374 31 P2 P2 NNP cord-010092-uftc8inx 374 32 phenotypes phenotype NNS cord-010092-uftc8inx 374 33 has have VBZ cord-010092-uftc8inx 374 34 remained remain VBN cord-010092-uftc8inx 374 35 elusive elusive JJ cord-010092-uftc8inx 374 36 till till IN cord-010092-uftc8inx 374 37 recently recently RB cord-010092-uftc8inx 374 38 . . . cord-010092-uftc8inx 375 1 Several several JJ cord-010092-uftc8inx 375 2 cis cis JJ cord-010092-uftc8inx 375 3 - - HYPH cord-010092-uftc8inx 375 4 regulatory regulatory JJ cord-010092-uftc8inx 375 5 SNPs SNPs NNPS cord-010092-uftc8inx 375 6 had have VBD cord-010092-uftc8inx 375 7 been be VBN cord-010092-uftc8inx 375 8 identified identify VBN cord-010092-uftc8inx 375 9 in in IN cord-010092-uftc8inx 375 10 non non JJ cord-010092-uftc8inx 375 11 - - JJ cord-010092-uftc8inx 375 12 coding coding JJ cord-010092-uftc8inx 375 13 sequences sequence NNS cord-010092-uftc8inx 375 14 around around IN cord-010092-uftc8inx 375 15 exon exon NN cord-010092-uftc8inx 375 16 2a 2a CD cord-010092-uftc8inx 375 17 , , , cord-010092-uftc8inx 375 18 which which WDT cord-010092-uftc8inx 375 19 showed show VBD cord-010092-uftc8inx 375 20 a a DT cord-010092-uftc8inx 375 21 very very RB cord-010092-uftc8inx 375 22 good good JJ cord-010092-uftc8inx 375 23 correlation correlation NN cord-010092-uftc8inx 375 24 with with IN cord-010092-uftc8inx 375 25 P1 P1 NNP cord-010092-uftc8inx 375 26 antigen antigen NN cord-010092-uftc8inx 375 27 expression expression NN cord-010092-uftc8inx 375 28 . . . cord-010092-uftc8inx 376 1 Interestingly interestingly RB cord-010092-uftc8inx 376 2 , , , cord-010092-uftc8inx 376 3 potential potential JJ cord-010092-uftc8inx 376 4 binding bind VBG cord-010092-uftc8inx 376 5 sites site NNS cord-010092-uftc8inx 376 6 for for IN cord-010092-uftc8inx 376 7 several several JJ cord-010092-uftc8inx 376 8 hematopoietic hematopoietic JJ cord-010092-uftc8inx 376 9 TFs tf NNS cord-010092-uftc8inx 376 10 were be VBD cord-010092-uftc8inx 376 11 identified identify VBN cord-010092-uftc8inx 376 12 in in IN cord-010092-uftc8inx 376 13 the the DT cord-010092-uftc8inx 376 14 same same JJ cord-010092-uftc8inx 376 15 region region NN cord-010092-uftc8inx 376 16 . . . cord-010092-uftc8inx 377 1 Finally finally RB cord-010092-uftc8inx 377 2 , , , cord-010092-uftc8inx 377 3 recent recent JJ cord-010092-uftc8inx 377 4 investigations investigation NNS cord-010092-uftc8inx 377 5 have have VBP cord-010092-uftc8inx 377 6 demonstrated demonstrate VBN cord-010092-uftc8inx 377 7 the the DT cord-010092-uftc8inx 377 8 role role NN cord-010092-uftc8inx 377 9 of of IN cord-010092-uftc8inx 377 10 the the DT cord-010092-uftc8inx 377 11 RUNX1 runx1 JJ cord-010092-uftc8inx 377 12 TF TF NNP cord-010092-uftc8inx 377 13 in in IN cord-010092-uftc8inx 377 14 the the DT cord-010092-uftc8inx 377 15 expression expression NN cord-010092-uftc8inx 377 16 of of IN cord-010092-uftc8inx 377 17 P1 P1 NNP cord-010092-uftc8inx 377 18 antigen antigen NN cord-010092-uftc8inx 377 19 , , , cord-010092-uftc8inx 377 20 by by IN cord-010092-uftc8inx 377 21 selective selective JJ cord-010092-uftc8inx 377 22 binding binding NN cord-010092-uftc8inx 377 23 to to IN cord-010092-uftc8inx 377 24 a a DT cord-010092-uftc8inx 377 25 regulatory regulatory JJ cord-010092-uftc8inx 377 26 site site NN cord-010092-uftc8inx 377 27 present present JJ cord-010092-uftc8inx 377 28 in in IN cord-010092-uftc8inx 377 29 P1 P1 NNP cord-010092-uftc8inx 377 30 but but CC cord-010092-uftc8inx 377 31 not not RB cord-010092-uftc8inx 377 32 in in IN cord-010092-uftc8inx 377 33 P2 P2 NNP cord-010092-uftc8inx 377 34 alleles allele NNS cord-010092-uftc8inx 377 35 . . . cord-010092-uftc8inx 378 1 To to TO cord-010092-uftc8inx 378 2 summarize summarize VB cord-010092-uftc8inx 378 3 , , , cord-010092-uftc8inx 378 4 variation variation NN cord-010092-uftc8inx 378 5 in in IN cord-010092-uftc8inx 378 6 blood blood NN cord-010092-uftc8inx 378 7 group group NN cord-010092-uftc8inx 378 8 antigen antigen NN cord-010092-uftc8inx 378 9 expression expression NN cord-010092-uftc8inx 378 10 may may MD cord-010092-uftc8inx 378 11 result result VB cord-010092-uftc8inx 378 12 from from IN cord-010092-uftc8inx 378 13 mutations mutation NNS cord-010092-uftc8inx 378 14 or or CC cord-010092-uftc8inx 378 15 polymorphisms polymorphism NNS cord-010092-uftc8inx 378 16 in in IN cord-010092-uftc8inx 378 17 the the DT cord-010092-uftc8inx 378 18 regulatory regulatory JJ cord-010092-uftc8inx 378 19 region region NN cord-010092-uftc8inx 378 20 of of IN cord-010092-uftc8inx 378 21 blood blood NN cord-010092-uftc8inx 378 22 group group NN cord-010092-uftc8inx 378 23 genes gene NNS cord-010092-uftc8inx 378 24 . . . cord-010092-uftc8inx 379 1 Recent recent JJ cord-010092-uftc8inx 379 2 reports report NNS cord-010092-uftc8inx 379 3 have have VBP cord-010092-uftc8inx 379 4 unravelled unravel VBN cord-010092-uftc8inx 379 5 the the DT cord-010092-uftc8inx 379 6 molecular molecular JJ cord-010092-uftc8inx 379 7 mechanisms mechanism NNS cord-010092-uftc8inx 379 8 underlying underlie VBG cord-010092-uftc8inx 379 9 the the DT cord-010092-uftc8inx 379 10 expression expression NN cord-010092-uftc8inx 379 11 of of IN cord-010092-uftc8inx 379 12 P1 P1 NNP cord-010092-uftc8inx 379 13 and and CC cord-010092-uftc8inx 379 14 Xga Xga NNP cord-010092-uftc8inx 379 15 blood blood NN cord-010092-uftc8inx 379 16 group group NN cord-010092-uftc8inx 379 17 antigens antigen NNS cord-010092-uftc8inx 379 18 , , , cord-010092-uftc8inx 379 19 which which WDT cord-010092-uftc8inx 379 20 involves involve VBZ cord-010092-uftc8inx 379 21 TF TF NNP cord-010092-uftc8inx 379 22 binding bind VBG cord-010092-uftc8inx 379 23 to to IN cord-010092-uftc8inx 379 24 allele allele NN cord-010092-uftc8inx 379 25 - - HYPH cord-010092-uftc8inx 379 26 specific specific JJ cord-010092-uftc8inx 379 27 regulatory regulatory JJ cord-010092-uftc8inx 379 28 elements element NNS cord-010092-uftc8inx 379 29 . . . cord-010092-uftc8inx 380 1 Similar similar JJ cord-010092-uftc8inx 380 2 mechanisms mechanism NNS cord-010092-uftc8inx 380 3 may may MD cord-010092-uftc8inx 380 4 also also RB cord-010092-uftc8inx 380 5 regulate regulate VB cord-010092-uftc8inx 380 6 antigen antigen NN cord-010092-uftc8inx 380 7 expression expression NN cord-010092-uftc8inx 380 8 in in IN cord-010092-uftc8inx 380 9 other other JJ cord-010092-uftc8inx 380 10 blood blood NN cord-010092-uftc8inx 380 11 group group NN cord-010092-uftc8inx 380 12 systems system NNS cord-010092-uftc8inx 380 13 . . . cord-010092-uftc8inx 381 1 2C-06 2c-06 CD cord-010092-uftc8inx 381 2 - - SYM cord-010092-uftc8inx 381 3 03 03 CD cord-010092-uftc8inx 382 1 Clinical clinical JJ cord-010092-uftc8inx 382 2 Immunology Immunology NNP cord-010092-uftc8inx 382 3 , , , cord-010092-uftc8inx 382 4 Copenhagen Copenhagen NNP cord-010092-uftc8inx 382 5 University University NNP cord-010092-uftc8inx 382 6 Hospital Hospital NNP cord-010092-uftc8inx 382 7 , , , cord-010092-uftc8inx 382 8 Copenhagen Copenhagen NNP cord-010092-uftc8inx 382 9 , , , cord-010092-uftc8inx 382 10 Denmark Denmark NNP cord-010092-uftc8inx 383 1 Since since IN cord-010092-uftc8inx 383 2 the the DT cord-010092-uftc8inx 383 3 discovery discovery NN cord-010092-uftc8inx 383 4 of of IN cord-010092-uftc8inx 383 5 cell cell NN cord-010092-uftc8inx 383 6 - - HYPH cord-010092-uftc8inx 383 7 free free JJ cord-010092-uftc8inx 383 8 fetal fetal JJ cord-010092-uftc8inx 383 9 DNA dna NN cord-010092-uftc8inx 383 10 ( ( -LRB- cord-010092-uftc8inx 383 11 cffDNA cffdna RB cord-010092-uftc8inx 383 12 ) ) -RRB- cord-010092-uftc8inx 383 13 in in IN cord-010092-uftc8inx 383 14 pregnant pregnant JJ cord-010092-uftc8inx 383 15 women woman NNS cord-010092-uftc8inx 383 16 's 's POS cord-010092-uftc8inx 383 17 blood blood NN cord-010092-uftc8inx 383 18 , , , cord-010092-uftc8inx 383 19 the the DT cord-010092-uftc8inx 383 20 development development NN cord-010092-uftc8inx 383 21 of of IN cord-010092-uftc8inx 383 22 noninvasive noninvasive JJ cord-010092-uftc8inx 383 23 prenatal prenatal JJ cord-010092-uftc8inx 383 24 testing testing NN cord-010092-uftc8inx 383 25 ( ( -LRB- cord-010092-uftc8inx 383 26 NIPT NIPT NNP cord-010092-uftc8inx 383 27 ) ) -RRB- cord-010092-uftc8inx 383 28 has have VBZ cord-010092-uftc8inx 383 29 provided provide VBN cord-010092-uftc8inx 383 30 new new JJ cord-010092-uftc8inx 383 31 diagnostic diagnostic JJ cord-010092-uftc8inx 383 32 applications application NNS cord-010092-uftc8inx 383 33 in in IN cord-010092-uftc8inx 383 34 prenatal prenatal JJ cord-010092-uftc8inx 383 35 care care NN cord-010092-uftc8inx 383 36 . . . cord-010092-uftc8inx 384 1 In in IN cord-010092-uftc8inx 384 2 transfusion transfusion NN cord-010092-uftc8inx 384 3 medicine medicine NN cord-010092-uftc8inx 384 4 and and CC cord-010092-uftc8inx 384 5 clinical clinical JJ cord-010092-uftc8inx 384 6 immunology immunology NN cord-010092-uftc8inx 384 7 , , , cord-010092-uftc8inx 384 8 cffDNA cffDNA NNP cord-010092-uftc8inx 384 9 is be VBZ cord-010092-uftc8inx 384 10 extracted extract VBN cord-010092-uftc8inx 384 11 from from IN cord-010092-uftc8inx 384 12 maternal maternal JJ cord-010092-uftc8inx 384 13 plasma plasma NN cord-010092-uftc8inx 384 14 to to TO cord-010092-uftc8inx 384 15 predict predict VB cord-010092-uftc8inx 384 16 fetal fetal JJ cord-010092-uftc8inx 384 17 blood blood NN cord-010092-uftc8inx 384 18 groups group NNS cord-010092-uftc8inx 384 19 with with IN cord-010092-uftc8inx 384 20 the the DT cord-010092-uftc8inx 384 21 purpose purpose NN cord-010092-uftc8inx 384 22 of of IN cord-010092-uftc8inx 384 23 1 1 CD cord-010092-uftc8inx 384 24 ) ) -RRB- cord-010092-uftc8inx 384 25 guiding guide VBG cord-010092-uftc8inx 384 26 targeted target VBN cord-010092-uftc8inx 384 27 Rh Rh NNP cord-010092-uftc8inx 384 28 prophylaxis prophylaxis NN cord-010092-uftc8inx 384 29 in in IN cord-010092-uftc8inx 384 30 non non JJ cord-010092-uftc8inx 384 31 - - JJ cord-010092-uftc8inx 384 32 immunized immunized JJ cord-010092-uftc8inx 384 33 RhD rhd NN cord-010092-uftc8inx 384 34 negative negative JJ cord-010092-uftc8inx 384 35 women woman NNS cord-010092-uftc8inx 384 36 and and CC cord-010092-uftc8inx 384 37 2 2 LS cord-010092-uftc8inx 384 38 ) ) -RRB- cord-010092-uftc8inx 384 39 assessing assess VBG cord-010092-uftc8inx 384 40 the the DT cord-010092-uftc8inx 384 41 risk risk NN cord-010092-uftc8inx 384 42 of of IN cord-010092-uftc8inx 384 43 hemolytic hemolytic JJ cord-010092-uftc8inx 384 44 disease disease NN cord-010092-uftc8inx 384 45 of of IN cord-010092-uftc8inx 384 46 the the DT cord-010092-uftc8inx 384 47 fetus fetus NN cord-010092-uftc8inx 384 48 and and CC cord-010092-uftc8inx 384 49 newborn newborn JJ cord-010092-uftc8inx 384 50 ( ( -LRB- cord-010092-uftc8inx 384 51 HDFN HDFN NNP cord-010092-uftc8inx 384 52 ) ) -RRB- cord-010092-uftc8inx 384 53 in in IN cord-010092-uftc8inx 384 54 immunized immunize VBN cord-010092-uftc8inx 384 55 women woman NNS cord-010092-uftc8inx 384 56 . . . cord-010092-uftc8inx 385 1 I -PRON- PRP cord-010092-uftc8inx 385 2 will will MD cord-010092-uftc8inx 385 3 give give VB cord-010092-uftc8inx 385 4 an an DT cord-010092-uftc8inx 385 5 overview overview NN cord-010092-uftc8inx 385 6 of of IN cord-010092-uftc8inx 385 7 noninvasive noninvasive JJ cord-010092-uftc8inx 385 8 prenatal prenatal JJ cord-010092-uftc8inx 385 9 testing testing NN cord-010092-uftc8inx 385 10 of of IN cord-010092-uftc8inx 385 11 fetal fetal JJ cord-010092-uftc8inx 385 12 blood blood NN cord-010092-uftc8inx 385 13 groups group NNS cord-010092-uftc8inx 385 14 . . . cord-010092-uftc8inx 386 1 Based base VBN cord-010092-uftc8inx 386 2 on on IN cord-010092-uftc8inx 386 3 the the DT cord-010092-uftc8inx 386 4 literature literature NN cord-010092-uftc8inx 386 5 , , , cord-010092-uftc8inx 386 6 I -PRON- PRP cord-010092-uftc8inx 386 7 will will MD cord-010092-uftc8inx 386 8 summarize summarize VB cord-010092-uftc8inx 386 9 the the DT cord-010092-uftc8inx 386 10 current current JJ cord-010092-uftc8inx 386 11 experience experience NN cord-010092-uftc8inx 386 12 with with IN cord-010092-uftc8inx 386 13 noninvasive noninvasive JJ cord-010092-uftc8inx 386 14 prenatal prenatal JJ cord-010092-uftc8inx 386 15 testing testing NN cord-010092-uftc8inx 386 16 of of IN cord-010092-uftc8inx 386 17 fetal fetal JJ cord-010092-uftc8inx 386 18 RHD RHD NNP cord-010092-uftc8inx 386 19 and and CC cord-010092-uftc8inx 386 20 other other JJ cord-010092-uftc8inx 386 21 blood blood NN cord-010092-uftc8inx 386 22 groups group NNS cord-010092-uftc8inx 386 23 . . . cord-010092-uftc8inx 387 1 For for IN cord-010092-uftc8inx 387 2 RhD rhd NN cord-010092-uftc8inx 387 3 negative negative JJ cord-010092-uftc8inx 387 4 pregnant pregnant JJ cord-010092-uftc8inx 387 5 women woman NNS cord-010092-uftc8inx 387 6 , , , cord-010092-uftc8inx 387 7 routine routine JJ cord-010092-uftc8inx 387 8 clinical clinical JJ cord-010092-uftc8inx 387 9 testing testing NN cord-010092-uftc8inx 387 10 is be VBZ cord-010092-uftc8inx 387 11 available available JJ cord-010092-uftc8inx 387 12 in in IN cord-010092-uftc8inx 387 13 several several JJ cord-010092-uftc8inx 387 14 countries country NNS cord-010092-uftc8inx 387 15 world world NN cord-010092-uftc8inx 387 16 - - HYPH cord-010092-uftc8inx 387 17 wide wide RB cord-010092-uftc8inx 387 18 to to TO cord-010092-uftc8inx 387 19 assess assess VB cord-010092-uftc8inx 387 20 the the DT cord-010092-uftc8inx 387 21 risk risk NN cord-010092-uftc8inx 387 22 of of IN cord-010092-uftc8inx 387 23 HDFN HDFN NNP cord-010092-uftc8inx 387 24 in in IN cord-010092-uftc8inx 387 25 D D NNP cord-010092-uftc8inx 387 26 immunized immunize VBD cord-010092-uftc8inx 387 27 women woman NNS cord-010092-uftc8inx 387 28 , , , cord-010092-uftc8inx 387 29 and and CC cord-010092-uftc8inx 387 30 routine routine JJ cord-010092-uftc8inx 387 31 testing testing NN cord-010092-uftc8inx 387 32 to to TO cord-010092-uftc8inx 387 33 guide guide VB cord-010092-uftc8inx 387 34 Rh Rh NNP cord-010092-uftc8inx 387 35 prophylaxis prophylaxis NN cord-010092-uftc8inx 387 36 is be VBZ cord-010092-uftc8inx 387 37 now now RB cord-010092-uftc8inx 387 38 implemented implement VBN cord-010092-uftc8inx 387 39 as as IN cord-010092-uftc8inx 387 40 nationwide nationwide JJ cord-010092-uftc8inx 387 41 service service NN cord-010092-uftc8inx 387 42 in in IN cord-010092-uftc8inx 387 43 6 6 CD cord-010092-uftc8inx 387 44 - - SYM cord-010092-uftc8inx 387 45 7 7 CD cord-010092-uftc8inx 387 46 European european JJ cord-010092-uftc8inx 387 47 countries country NNS cord-010092-uftc8inx 387 48 . . . cord-010092-uftc8inx 388 1 Noninvasive noninvasive JJ cord-010092-uftc8inx 388 2 prenatal prenatal JJ cord-010092-uftc8inx 388 3 testing testing NN cord-010092-uftc8inx 388 4 for for IN cord-010092-uftc8inx 388 5 fetal fetal JJ cord-010092-uftc8inx 388 6 RHD RHD NNP cord-010092-uftc8inx 388 7 is be VBZ cord-010092-uftc8inx 388 8 highly highly RB cord-010092-uftc8inx 388 9 accurate accurate JJ cord-010092-uftc8inx 388 10 with with IN cord-010092-uftc8inx 388 11 sensitivities sensitivity NNS cord-010092-uftc8inx 388 12 of of IN cord-010092-uftc8inx 388 13 99.9 99.9 CD cord-010092-uftc8inx 388 14 % % NN cord-010092-uftc8inx 388 15 , , , cord-010092-uftc8inx 388 16 as as IN cord-010092-uftc8inx 388 17 reported report VBN cord-010092-uftc8inx 388 18 from from IN cord-010092-uftc8inx 388 19 clinical clinical JJ cord-010092-uftc8inx 388 20 programs program NNS cord-010092-uftc8inx 388 21 . . . cord-010092-uftc8inx 389 1 In in IN cord-010092-uftc8inx 389 2 general general JJ cord-010092-uftc8inx 389 3 , , , cord-010092-uftc8inx 389 4 the the DT cord-010092-uftc8inx 389 5 sensitivity sensitivity NN cord-010092-uftc8inx 389 6 is be VBZ cord-010092-uftc8inx 389 7 challenged challenge VBN cord-010092-uftc8inx 389 8 be be VB cord-010092-uftc8inx 389 9 low low JJ cord-010092-uftc8inx 389 10 quantities quantity NNS cord-010092-uftc8inx 389 11 of of IN cord-010092-uftc8inx 389 12 cffDNA cffdna NN cord-010092-uftc8inx 389 13 , , , cord-010092-uftc8inx 389 14 especially especially RB cord-010092-uftc8inx 389 15 in in IN cord-010092-uftc8inx 389 16 early early JJ cord-010092-uftc8inx 389 17 pregnancy pregnancy NN cord-010092-uftc8inx 389 18 . . . cord-010092-uftc8inx 390 1 The the DT cord-010092-uftc8inx 390 2 specificity specificity NN cord-010092-uftc8inx 390 3 is be VBZ cord-010092-uftc8inx 390 4 challenged challenge VBN cord-010092-uftc8inx 390 5 by by IN cord-010092-uftc8inx 390 6 the the DT cord-010092-uftc8inx 390 7 polymorphic polymorphic JJ cord-010092-uftc8inx 390 8 Rh Rh NNP cord-010092-uftc8inx 390 9 blood blood NN cord-010092-uftc8inx 390 10 group group NN cord-010092-uftc8inx 390 11 system system NN cord-010092-uftc8inx 390 12 , , , cord-010092-uftc8inx 390 13 where where WRB cord-010092-uftc8inx 390 14 careful careful JJ cord-010092-uftc8inx 390 15 attention attention NN cord-010092-uftc8inx 390 16 is be VBZ cord-010092-uftc8inx 390 17 needed need VBN cord-010092-uftc8inx 390 18 to to TO cord-010092-uftc8inx 390 19 navigate navigate VB cord-010092-uftc8inx 390 20 among among IN cord-010092-uftc8inx 390 21 the the DT cord-010092-uftc8inx 390 22 many many JJ cord-010092-uftc8inx 390 23 RHD RHD NNP cord-010092-uftc8inx 390 24 variants variant NNS cord-010092-uftc8inx 390 25 . . . cord-010092-uftc8inx 391 1 RHD RHD NNP cord-010092-uftc8inx 391 2 variants variant NNS cord-010092-uftc8inx 391 3 may may MD cord-010092-uftc8inx 391 4 complicate complicate VB cord-010092-uftc8inx 391 5 cffDNA cffdna JJ cord-010092-uftc8inx 391 6 analysis analysis NN cord-010092-uftc8inx 391 7 and and CC cord-010092-uftc8inx 391 8 interpretation interpretation NN cord-010092-uftc8inx 391 9 of of IN cord-010092-uftc8inx 391 10 results result NNS cord-010092-uftc8inx 391 11 , , , cord-010092-uftc8inx 391 12 especially especially RB cord-010092-uftc8inx 391 13 in in IN cord-010092-uftc8inx 391 14 populations population NNS cord-010092-uftc8inx 391 15 with with IN cord-010092-uftc8inx 391 16 mixed mixed JJ cord-010092-uftc8inx 391 17 ethnicities ethnicity NNS cord-010092-uftc8inx 391 18 . . . cord-010092-uftc8inx 392 1 Despite despite IN cord-010092-uftc8inx 392 2 these these DT cord-010092-uftc8inx 392 3 challenges challenge NNS cord-010092-uftc8inx 392 4 , , , cord-010092-uftc8inx 392 5 fetal fetal JJ cord-010092-uftc8inx 392 6 RHD rhd NN cord-010092-uftc8inx 392 7 testing testing NN cord-010092-uftc8inx 392 8 is be VBZ cord-010092-uftc8inx 392 9 very very RB cord-010092-uftc8inx 392 10 feasible feasible JJ cord-010092-uftc8inx 392 11 when when WRB cord-010092-uftc8inx 392 12 implemented implement VBN cord-010092-uftc8inx 392 13 with with IN cord-010092-uftc8inx 392 14 careful careful JJ cord-010092-uftc8inx 392 15 attention attention NN cord-010092-uftc8inx 392 16 to to IN cord-010092-uftc8inx 392 17 these these DT cord-010092-uftc8inx 392 18 issues issue NNS cord-010092-uftc8inx 392 19 . . . cord-010092-uftc8inx 393 1 For for IN cord-010092-uftc8inx 393 2 blood blood NN cord-010092-uftc8inx 393 3 groups group NNS cord-010092-uftc8inx 393 4 that that WDT cord-010092-uftc8inx 393 5 are be VBP cord-010092-uftc8inx 393 6 determined determine VBN cord-010092-uftc8inx 393 7 by by IN cord-010092-uftc8inx 393 8 SNPs snp NNS cord-010092-uftc8inx 393 9 , , , cord-010092-uftc8inx 393 10 such such JJ cord-010092-uftc8inx 393 11 as as IN cord-010092-uftc8inx 393 12 KEL KEL NNP cord-010092-uftc8inx 393 13 or or CC cord-010092-uftc8inx 393 14 Rhc Rhc NNP cord-010092-uftc8inx 393 15 , , , cord-010092-uftc8inx 393 16 the the DT cord-010092-uftc8inx 393 17 main main JJ cord-010092-uftc8inx 393 18 challenge challenge NN cord-010092-uftc8inx 393 19 has have VBZ cord-010092-uftc8inx 393 20 been be VBN cord-010092-uftc8inx 393 21 interference interference NN cord-010092-uftc8inx 393 22 from from IN cord-010092-uftc8inx 393 23 the the DT cord-010092-uftc8inx 393 24 maternal maternal JJ cord-010092-uftc8inx 393 25 DNA dna NN cord-010092-uftc8inx 393 26 when when WRB cord-010092-uftc8inx 393 27 analyzing analyze VBG cord-010092-uftc8inx 393 28 the the DT cord-010092-uftc8inx 393 29 fetal fetal JJ cord-010092-uftc8inx 393 30 DNA dna NN cord-010092-uftc8inx 393 31 which which WDT cord-010092-uftc8inx 393 32 has have VBZ cord-010092-uftc8inx 393 33 resulted result VBN cord-010092-uftc8inx 393 34 in in IN cord-010092-uftc8inx 393 35 low low JJ cord-010092-uftc8inx 393 36 accuracy accuracy NN cord-010092-uftc8inx 393 37 and and CC cord-010092-uftc8inx 393 38 lower low JJR cord-010092-uftc8inx 393 39 sensitivity sensitivity NN cord-010092-uftc8inx 393 40 , , , cord-010092-uftc8inx 393 41 when when WRB cord-010092-uftc8inx 393 42 using use VBG cord-010092-uftc8inx 393 43 qPCR qpcr NN cord-010092-uftc8inx 393 44 . . . cord-010092-uftc8inx 394 1 With with IN cord-010092-uftc8inx 394 2 the the DT cord-010092-uftc8inx 394 3 application application NN cord-010092-uftc8inx 394 4 of of IN cord-010092-uftc8inx 394 5 more more JJR cord-010092-uftc8inx 394 6 novel novel JJ cord-010092-uftc8inx 394 7 techniques technique NNS cord-010092-uftc8inx 394 8 such such JJ cord-010092-uftc8inx 394 9 as as IN cord-010092-uftc8inx 394 10 next next JJ cord-010092-uftc8inx 394 11 generation generation NN cord-010092-uftc8inx 394 12 sequencing sequencing NN cord-010092-uftc8inx 394 13 and and CC cord-010092-uftc8inx 394 14 droplet droplet NN cord-010092-uftc8inx 394 15 digital digital JJ cord-010092-uftc8inx 394 16 PCR PCR NNP cord-010092-uftc8inx 394 17 , , , cord-010092-uftc8inx 394 18 accurate accurate JJ cord-010092-uftc8inx 394 19 noninvasive noninvasive JJ cord-010092-uftc8inx 394 20 prediction prediction NN cord-010092-uftc8inx 394 21 of of IN cord-010092-uftc8inx 394 22 these these DT cord-010092-uftc8inx 394 23 fetal fetal JJ cord-010092-uftc8inx 394 24 blood blood NN cord-010092-uftc8inx 394 25 groups group NNS cord-010092-uftc8inx 394 26 has have VBZ cord-010092-uftc8inx 394 27 been be VBN cord-010092-uftc8inx 394 28 demonstrated demonstrate VBN cord-010092-uftc8inx 394 29 . . . cord-010092-uftc8inx 395 1 The the DT cord-010092-uftc8inx 395 2 success success NN cord-010092-uftc8inx 395 3 of of IN cord-010092-uftc8inx 395 4 predicting predict VBG cord-010092-uftc8inx 395 5 fetal fetal JJ cord-010092-uftc8inx 395 6 RhD rhd NN cord-010092-uftc8inx 395 7 and and CC cord-010092-uftc8inx 395 8 its -PRON- PRP$ cord-010092-uftc8inx 395 9 successful successful JJ cord-010092-uftc8inx 395 10 clinical clinical JJ cord-010092-uftc8inx 395 11 implementation implementation NN cord-010092-uftc8inx 395 12 into into IN cord-010092-uftc8inx 395 13 national national JJ cord-010092-uftc8inx 395 14 programs program NNS cord-010092-uftc8inx 395 15 should should MD cord-010092-uftc8inx 395 16 encourage encourage VB cord-010092-uftc8inx 395 17 wide wide JJ cord-010092-uftc8inx 395 18 - - HYPH cord-010092-uftc8inx 395 19 spread spread VBN cord-010092-uftc8inx 395 20 use use NN cord-010092-uftc8inx 395 21 of of IN cord-010092-uftc8inx 395 22 cell cell NN cord-010092-uftc8inx 395 23 - - HYPH cord-010092-uftc8inx 395 24 free free JJ cord-010092-uftc8inx 395 25 DNA dna NN cord-010092-uftc8inx 395 26 based base VBN cord-010092-uftc8inx 395 27 analysis analysis NN cord-010092-uftc8inx 395 28 . . . cord-010092-uftc8inx 396 1 Future future JJ cord-010092-uftc8inx 396 2 work work NN cord-010092-uftc8inx 396 3 on on IN cord-010092-uftc8inx 396 4 noninvasive noninvasive JJ cord-010092-uftc8inx 396 5 prenatal prenatal JJ cord-010092-uftc8inx 396 6 testing testing NN cord-010092-uftc8inx 396 7 of of IN cord-010092-uftc8inx 396 8 fetal fetal JJ cord-010092-uftc8inx 396 9 blood blood NN cord-010092-uftc8inx 396 10 groups group NNS cord-010092-uftc8inx 396 11 determined determine VBN cord-010092-uftc8inx 396 12 by by IN cord-010092-uftc8inx 396 13 SNPs snp NNS cord-010092-uftc8inx 396 14 may may MD cord-010092-uftc8inx 396 15 consolidate consolidate VB cord-010092-uftc8inx 396 16 the the DT cord-010092-uftc8inx 396 17 application application NN cord-010092-uftc8inx 396 18 for for IN cord-010092-uftc8inx 396 19 cell cell NN cord-010092-uftc8inx 396 20 - - HYPH cord-010092-uftc8inx 396 21 free free JJ cord-010092-uftc8inx 396 22 DNA dna NN cord-010092-uftc8inx 396 23 testing testing NN cord-010092-uftc8inx 396 24 for for IN cord-010092-uftc8inx 396 25 such such JJ cord-010092-uftc8inx 396 26 targets target NNS cord-010092-uftc8inx 396 27 , , , cord-010092-uftc8inx 396 28 including include VBG cord-010092-uftc8inx 396 29 human human JJ cord-010092-uftc8inx 396 30 platelet platelet NN cord-010092-uftc8inx 396 31 antigens antigen NNS cord-010092-uftc8inx 396 32 . . . cord-010092-uftc8inx 397 1 At at IN cord-010092-uftc8inx 397 2 ISBT ISBT NNP cord-010092-uftc8inx 397 3 , , , cord-010092-uftc8inx 397 4 the the DT cord-010092-uftc8inx 397 5 newly newly RB cord-010092-uftc8inx 397 6 formed form VBN cord-010092-uftc8inx 397 7 cfDNA cfdna RB cord-010092-uftc8inx 397 8 subgroup subgroup NN cord-010092-uftc8inx 397 9 of of IN cord-010092-uftc8inx 397 10 the the DT cord-010092-uftc8inx 397 11 Red Red NNP cord-010092-uftc8inx 397 12 Cell Cell NNP cord-010092-uftc8inx 397 13 Immunogenetics Immunogenetics NNP cord-010092-uftc8inx 397 14 and and CC cord-010092-uftc8inx 397 15 Blood Blood NNP cord-010092-uftc8inx 397 16 Group Group NNP cord-010092-uftc8inx 397 17 Terminology Terminology NNP cord-010092-uftc8inx 397 18 Working Working NNP cord-010092-uftc8inx 397 19 Party Party NNP cord-010092-uftc8inx 397 20 will will MD cord-010092-uftc8inx 397 21 work work VB cord-010092-uftc8inx 397 22 to to TO cord-010092-uftc8inx 397 23 facilitate facilitate VB cord-010092-uftc8inx 397 24 clinical clinical JJ cord-010092-uftc8inx 397 25 applications application NNS cord-010092-uftc8inx 397 26 , , , cord-010092-uftc8inx 397 27 implementation implementation NN cord-010092-uftc8inx 397 28 and and CC cord-010092-uftc8inx 397 29 evaluation evaluation NN cord-010092-uftc8inx 397 30 of of IN cord-010092-uftc8inx 397 31 cell cell NN cord-010092-uftc8inx 397 32 - - HYPH cord-010092-uftc8inx 397 33 free free JJ cord-010092-uftc8inx 397 34 DNA dna NN cord-010092-uftc8inx 397 35 testing testing NN cord-010092-uftc8inx 397 36 . . . cord-010092-uftc8inx 398 1 Blood blood NN cord-010092-uftc8inx 398 2 banks bank NNS cord-010092-uftc8inx 398 3 in in IN cord-010092-uftc8inx 398 4 most most JJS cord-010092-uftc8inx 398 5 of of IN cord-010092-uftc8inx 398 6 the the DT cord-010092-uftc8inx 398 7 Nordic nordic JJ cord-010092-uftc8inx 398 8 countries country NNS cord-010092-uftc8inx 398 9 all all DT cord-010092-uftc8inx 398 10 share share VBP cord-010092-uftc8inx 398 11 a a DT cord-010092-uftc8inx 398 12 vein vein NN cord-010092-uftc8inx 398 13 - - HYPH cord-010092-uftc8inx 398 14 to to IN cord-010092-uftc8inx 398 15 - - HYPH cord-010092-uftc8inx 398 16 vein vein NN cord-010092-uftc8inx 398 17 approach approach NN cord-010092-uftc8inx 398 18 which which WDT cord-010092-uftc8inx 398 19 in in IN cord-010092-uftc8inx 398 20 short short JJ cord-010092-uftc8inx 398 21 means mean NNS cord-010092-uftc8inx 398 22 that that IN cord-010092-uftc8inx 398 23 the the DT cord-010092-uftc8inx 398 24 collection collection NN cord-010092-uftc8inx 398 25 of of IN cord-010092-uftc8inx 398 26 blood blood NN cord-010092-uftc8inx 398 27 , , , cord-010092-uftc8inx 398 28 the the DT cord-010092-uftc8inx 398 29 preparation preparation NN cord-010092-uftc8inx 398 30 of of IN cord-010092-uftc8inx 398 31 blood blood NN cord-010092-uftc8inx 398 32 components component NNS cord-010092-uftc8inx 398 33 , , , cord-010092-uftc8inx 398 34 testing testing NN cord-010092-uftc8inx 398 35 / / SYM cord-010092-uftc8inx 398 36 release release NN cord-010092-uftc8inx 398 37 and and CC cord-010092-uftc8inx 398 38 storing storing NN cord-010092-uftc8inx 398 39 is be VBZ cord-010092-uftc8inx 398 40 served serve VBN cord-010092-uftc8inx 398 41 by by IN cord-010092-uftc8inx 398 42 a a DT cord-010092-uftc8inx 398 43 single single JJ cord-010092-uftc8inx 398 44 actor actor NN cord-010092-uftc8inx 398 45 . . . cord-010092-uftc8inx 399 1 On on IN cord-010092-uftc8inx 399 2 top top NN cord-010092-uftc8inx 399 3 of of IN cord-010092-uftc8inx 399 4 that that DT cord-010092-uftc8inx 399 5 recipient recipient NN cord-010092-uftc8inx 399 6 and and CC cord-010092-uftc8inx 399 7 donor donor NN cord-010092-uftc8inx 399 8 blood blood NN cord-010092-uftc8inx 399 9 grouping grouping NN cord-010092-uftc8inx 399 10 , , , cord-010092-uftc8inx 399 11 crossmatching crossmatching NN cord-010092-uftc8inx 399 12 , , , cord-010092-uftc8inx 399 13 delivery delivery NN cord-010092-uftc8inx 399 14 , , , cord-010092-uftc8inx 399 15 registration registration NN cord-010092-uftc8inx 399 16 of of IN cord-010092-uftc8inx 399 17 transfusion transfusion NN cord-010092-uftc8inx 399 18 and and CC cord-010092-uftc8inx 399 19 of of IN cord-010092-uftc8inx 399 20 any any DT cord-010092-uftc8inx 399 21 complications complication NNS cord-010092-uftc8inx 399 22 is be VBZ cord-010092-uftc8inx 399 23 usually usually RB cord-010092-uftc8inx 399 24 handled handle VBN cord-010092-uftc8inx 399 25 in in IN cord-010092-uftc8inx 399 26 a a DT cord-010092-uftc8inx 399 27 single single JJ cord-010092-uftc8inx 399 28 blood blood NN cord-010092-uftc8inx 399 29 banking banking NN cord-010092-uftc8inx 399 30 information information NN cord-010092-uftc8inx 399 31 system system NN cord-010092-uftc8inx 399 32 ( ( -LRB- cord-010092-uftc8inx 399 33 BBIS BBIS NNP cord-010092-uftc8inx 399 34 ) ) -RRB- cord-010092-uftc8inx 399 35 . . . cord-010092-uftc8inx 400 1 This this DT cord-010092-uftc8inx 400 2 means mean VBZ cord-010092-uftc8inx 400 3 that that IN cord-010092-uftc8inx 400 4 blood blood NN cord-010092-uftc8inx 400 5 banks bank NNS cord-010092-uftc8inx 400 6 in in IN cord-010092-uftc8inx 400 7 the the DT cord-010092-uftc8inx 400 8 Nordics Nordics NNPS cord-010092-uftc8inx 400 9 are be VBP cord-010092-uftc8inx 400 10 traditionally traditionally RB cord-010092-uftc8inx 400 11 operated operate VBN cord-010092-uftc8inx 400 12 by by IN cord-010092-uftc8inx 400 13 a a DT cord-010092-uftc8inx 400 14 single single JJ cord-010092-uftc8inx 400 15 vendor vendor NN cord-010092-uftc8inx 400 16 . . . cord-010092-uftc8inx 401 1 The the DT cord-010092-uftc8inx 401 2 needs need NNS cord-010092-uftc8inx 401 3 for for IN cord-010092-uftc8inx 401 4 process process NN cord-010092-uftc8inx 401 5 control control NN cord-010092-uftc8inx 401 6 in in IN cord-010092-uftc8inx 401 7 a a DT cord-010092-uftc8inx 401 8 single single JJ cord-010092-uftc8inx 401 9 vendor vendor NN cord-010092-uftc8inx 401 10 BBIS BBIS NNP cord-010092-uftc8inx 401 11 , , , cord-010092-uftc8inx 401 12 the the DT cord-010092-uftc8inx 401 13 present present JJ cord-010092-uftc8inx 401 14 solutions solution NNS cord-010092-uftc8inx 401 15 , , , cord-010092-uftc8inx 401 16 unsolved unsolved JJ cord-010092-uftc8inx 401 17 challenges challenge NNS cord-010092-uftc8inx 401 18 and and CC cord-010092-uftc8inx 401 19 untapped untapped JJ cord-010092-uftc8inx 401 20 possibilities possibility NNS cord-010092-uftc8inx 401 21 of of IN cord-010092-uftc8inx 401 22 streamlining streamline VBG cord-010092-uftc8inx 401 23 processes process NNS cord-010092-uftc8inx 401 24 have have VBP cord-010092-uftc8inx 401 25 been be VBN cord-010092-uftc8inx 401 26 scrutinized scrutinize VBN cord-010092-uftc8inx 401 27 with with IN cord-010092-uftc8inx 401 28 the the DT cord-010092-uftc8inx 401 29 intention intention NN cord-010092-uftc8inx 401 30 to to TO cord-010092-uftc8inx 401 31 describe describe VB cord-010092-uftc8inx 401 32 separate separate JJ cord-010092-uftc8inx 401 33 processes process NNS cord-010092-uftc8inx 401 34 and and CC cord-010092-uftc8inx 401 35 to to TO cord-010092-uftc8inx 401 36 acquire acquire VB cord-010092-uftc8inx 401 37 best good JJS cord-010092-uftc8inx 401 38 of of IN cord-010092-uftc8inx 401 39 breed breed NN cord-010092-uftc8inx 401 40 or or CC cord-010092-uftc8inx 401 41 best good JJS cord-010092-uftc8inx 401 42 of of IN cord-010092-uftc8inx 401 43 suite suite NN cord-010092-uftc8inx 401 44 IT it NN cord-010092-uftc8inx 401 45 - - HYPH cord-010092-uftc8inx 401 46 systems system NNS cord-010092-uftc8inx 401 47 . . . cord-010092-uftc8inx 402 1 The the DT cord-010092-uftc8inx 402 2 aim aim NN cord-010092-uftc8inx 402 3 for for IN cord-010092-uftc8inx 402 4 integrations integration NNS cord-010092-uftc8inx 402 5 , , , cord-010092-uftc8inx 402 6 rather rather RB cord-010092-uftc8inx 402 7 than than IN cord-010092-uftc8inx 402 8 building build VBG cord-010092-uftc8inx 402 9 an an DT cord-010092-uftc8inx 402 10 integrated integrate VBN cord-010092-uftc8inx 402 11 IT it NN cord-010092-uftc8inx 402 12 - - HYPH cord-010092-uftc8inx 402 13 system system NN cord-010092-uftc8inx 402 14 , , , cord-010092-uftc8inx 402 15 to to TO cord-010092-uftc8inx 402 16 support support VB cord-010092-uftc8inx 402 17 the the DT cord-010092-uftc8inx 402 18 need need NN cord-010092-uftc8inx 402 19 for for IN cord-010092-uftc8inx 402 20 a a DT cord-010092-uftc8inx 402 21 vein vein NN cord-010092-uftc8inx 402 22 - - HYPH cord-010092-uftc8inx 402 23 to to IN cord-010092-uftc8inx 402 24 - - HYPH cord-010092-uftc8inx 402 25 vein vein NN cord-010092-uftc8inx 402 26 process process NN cord-010092-uftc8inx 402 27 is be VBZ cord-010092-uftc8inx 402 28 a a DT cord-010092-uftc8inx 402 29 precondition precondition NN cord-010092-uftc8inx 402 30 in in IN cord-010092-uftc8inx 402 31 the the DT cord-010092-uftc8inx 402 32 Nordic nordic JJ cord-010092-uftc8inx 402 33 countries country NNS cord-010092-uftc8inx 402 34 . . . cord-010092-uftc8inx 403 1 With with IN cord-010092-uftc8inx 403 2 multiple multiple JJ cord-010092-uftc8inx 403 3 IT IT NNP cord-010092-uftc8inx 403 4 - - HYPH cord-010092-uftc8inx 403 5 systems system NNS cord-010092-uftc8inx 403 6 supporting support VBG cord-010092-uftc8inx 403 7 isolated isolate VBN cord-010092-uftc8inx 403 8 processes process NNS cord-010092-uftc8inx 403 9 , , , cord-010092-uftc8inx 403 10 we -PRON- PRP cord-010092-uftc8inx 403 11 intend intend VBP cord-010092-uftc8inx 403 12 to to TO cord-010092-uftc8inx 403 13 facilitate facilitate VB cord-010092-uftc8inx 403 14 development development NN cord-010092-uftc8inx 403 15 in in IN cord-010092-uftc8inx 403 16 these these DT cord-010092-uftc8inx 403 17 and and CC cord-010092-uftc8inx 403 18 furthermore furthermore RB cord-010092-uftc8inx 403 19 increase increase VB cord-010092-uftc8inx 403 20 the the DT cord-010092-uftc8inx 403 21 flexibility flexibility NN cord-010092-uftc8inx 403 22 in in IN cord-010092-uftc8inx 403 23 the the DT cord-010092-uftc8inx 403 24 whole whole JJ cord-010092-uftc8inx 403 25 process process NN cord-010092-uftc8inx 403 26 . . . cord-010092-uftc8inx 404 1 We -PRON- PRP cord-010092-uftc8inx 404 2 set set VBD cord-010092-uftc8inx 404 3 out out RP cord-010092-uftc8inx 404 4 to to TO cord-010092-uftc8inx 404 5 reveal reveal VB cord-010092-uftc8inx 404 6 any any DT cord-010092-uftc8inx 404 7 existing exist VBG cord-010092-uftc8inx 404 8 knowledge knowledge NN cord-010092-uftc8inx 404 9 in in IN cord-010092-uftc8inx 404 10 the the DT cord-010092-uftc8inx 404 11 literature literature NN cord-010092-uftc8inx 404 12 on on IN cord-010092-uftc8inx 404 13 IT IT NNP cord-010092-uftc8inx 404 14 vendor vendor NN cord-010092-uftc8inx 404 15 strategies strategy NNS cord-010092-uftc8inx 404 16 for for IN cord-010092-uftc8inx 404 17 blood blood NN cord-010092-uftc8inx 404 18 banks bank NNS cord-010092-uftc8inx 404 19 , , , cord-010092-uftc8inx 404 20 but but CC cord-010092-uftc8inx 404 21 we -PRON- PRP cord-010092-uftc8inx 404 22 did do VBD cord-010092-uftc8inx 404 23 n't not RB cord-010092-uftc8inx 404 24 succeed succeed VB cord-010092-uftc8inx 404 25 in in IN cord-010092-uftc8inx 404 26 identifying identify VBG cord-010092-uftc8inx 404 27 any any DT cord-010092-uftc8inx 404 28 relevant relevant JJ cord-010092-uftc8inx 404 29 literature literature NN cord-010092-uftc8inx 404 30 . . . cord-010092-uftc8inx 405 1 However however RB cord-010092-uftc8inx 405 2 , , , cord-010092-uftc8inx 405 3 a a DT cord-010092-uftc8inx 405 4 systematic systematic JJ cord-010092-uftc8inx 405 5 literature literature NN cord-010092-uftc8inx 405 6 study study NN cord-010092-uftc8inx 405 7 on on IN cord-010092-uftc8inx 405 8 vendor vendor NN cord-010092-uftc8inx 405 9 strategies strategy NNS cord-010092-uftc8inx 405 10 when when WRB cord-010092-uftc8inx 405 11 choosing choose VBG cord-010092-uftc8inx 405 12 Health Health NNP cord-010092-uftc8inx 405 13 IT IT NNP cord-010092-uftc8inx 405 14 was be VBD cord-010092-uftc8inx 405 15 based base VBN cord-010092-uftc8inx 405 16 on on IN cord-010092-uftc8inx 405 17 the the DT cord-010092-uftc8inx 405 18 PRISMA PRISMA NNP cord-010092-uftc8inx 405 19 method method NN cord-010092-uftc8inx 405 20 , , , cord-010092-uftc8inx 405 21 and and CC cord-010092-uftc8inx 405 22 identified identify VBD cord-010092-uftc8inx 405 23 837 837 CD cord-010092-uftc8inx 405 24 studies study NNS cord-010092-uftc8inx 405 25 , , , cord-010092-uftc8inx 405 26 but but CC cord-010092-uftc8inx 405 27 only only RB cord-010092-uftc8inx 405 28 10 10 CD cord-010092-uftc8inx 405 29 was be VBD cord-010092-uftc8inx 405 30 eligible eligible JJ cord-010092-uftc8inx 405 31 for for IN cord-010092-uftc8inx 405 32 full full JJ cord-010092-uftc8inx 405 33 text text NN cord-010092-uftc8inx 405 34 review review NN cord-010092-uftc8inx 405 35 and and CC cord-010092-uftc8inx 405 36 5 5 CD cord-010092-uftc8inx 405 37 met meet VBD cord-010092-uftc8inx 405 38 the the DT cord-010092-uftc8inx 405 39 inclusion inclusion NN cord-010092-uftc8inx 405 40 criteria criterion NNS cord-010092-uftc8inx 405 41 . . . cord-010092-uftc8inx 406 1 Even even RB cord-010092-uftc8inx 406 2 this this DT cord-010092-uftc8inx 406 3 broader broad JJR cord-010092-uftc8inx 406 4 literature literature NN cord-010092-uftc8inx 406 5 study study NN cord-010092-uftc8inx 406 6 reveals reveal VBZ cord-010092-uftc8inx 406 7 very very RB cord-010092-uftc8inx 406 8 little little JJ cord-010092-uftc8inx 406 9 evidence evidence NN cord-010092-uftc8inx 406 10 . . . cord-010092-uftc8inx 407 1 Two two CD cord-010092-uftc8inx 407 2 studies study NNS cord-010092-uftc8inx 407 3 find find VBP cord-010092-uftc8inx 407 4 single single JJ cord-010092-uftc8inx 407 5 vendor vendor NN cord-010092-uftc8inx 407 6 strategies strategy NNS cord-010092-uftc8inx 407 7 poor poor JJ cord-010092-uftc8inx 407 8 and and CC cord-010092-uftc8inx 407 9 conclude conclude VBP cord-010092-uftc8inx 407 10 " " `` cord-010092-uftc8inx 407 11 best good JJS cord-010092-uftc8inx 407 12 of of IN cord-010092-uftc8inx 407 13 suite suite NN cord-010092-uftc8inx 407 14 " " '' cord-010092-uftc8inx 407 15 solutions solution NNS cord-010092-uftc8inx 407 16 to to TO cord-010092-uftc8inx 407 17 be be VB cord-010092-uftc8inx 407 18 optimal optimal JJ cord-010092-uftc8inx 407 19 . . . cord-010092-uftc8inx 408 1 One one CD cord-010092-uftc8inx 408 2 study study NN cord-010092-uftc8inx 408 3 was be VBD cord-010092-uftc8inx 408 4 not not RB cord-010092-uftc8inx 408 5 able able JJ cord-010092-uftc8inx 408 6 to to TO cord-010092-uftc8inx 408 7 correlate correlate VB cord-010092-uftc8inx 408 8 vendor vendor NN cord-010092-uftc8inx 408 9 strategies strategy NNS cord-010092-uftc8inx 408 10 to to IN cord-010092-uftc8inx 408 11 the the DT cord-010092-uftc8inx 408 12 investigated investigate VBN cord-010092-uftc8inx 408 13 productivity productivity NN cord-010092-uftc8inx 408 14 , , , cord-010092-uftc8inx 408 15 but but CC cord-010092-uftc8inx 408 16 concludes conclude VBZ cord-010092-uftc8inx 408 17 that that IN cord-010092-uftc8inx 408 18 best good JJS cord-010092-uftc8inx 408 19 of of IN cord-010092-uftc8inx 408 20 suite suite NN cord-010092-uftc8inx 408 21 and and CC cord-010092-uftc8inx 408 22 best good JJS cord-010092-uftc8inx 408 23 of of IN cord-010092-uftc8inx 408 24 breed breed NN cord-010092-uftc8inx 408 25 strategies strategy NNS cord-010092-uftc8inx 408 26 requires require VBZ cord-010092-uftc8inx 408 27 larger large JJR cord-010092-uftc8inx 408 28 organizational organizational JJ cord-010092-uftc8inx 408 29 changes change NNS cord-010092-uftc8inx 408 30 than than IN cord-010092-uftc8inx 408 31 a a DT cord-010092-uftc8inx 408 32 single single JJ cord-010092-uftc8inx 408 33 vendor vendor NN cord-010092-uftc8inx 408 34 strategy strategy NN cord-010092-uftc8inx 408 35 . . . cord-010092-uftc8inx 409 1 In in IN cord-010092-uftc8inx 409 2 summary summary NN cord-010092-uftc8inx 409 3 , , , cord-010092-uftc8inx 409 4 the the DT cord-010092-uftc8inx 409 5 existing exist VBG cord-010092-uftc8inx 409 6 research research NN cord-010092-uftc8inx 409 7 is be VBZ cord-010092-uftc8inx 409 8 contradictory contradictory JJ cord-010092-uftc8inx 409 9 . . . cord-010092-uftc8inx 410 1 This this DT cord-010092-uftc8inx 410 2 paper paper NN cord-010092-uftc8inx 410 3 adds add VBZ cord-010092-uftc8inx 410 4 basic basic JJ cord-010092-uftc8inx 410 5 knowledge knowledge NN cord-010092-uftc8inx 410 6 for for IN cord-010092-uftc8inx 410 7 breaking break VBG cord-010092-uftc8inx 410 8 down down RP cord-010092-uftc8inx 410 9 the the DT cord-010092-uftc8inx 410 10 process process NN cord-010092-uftc8inx 410 11 control control NN cord-010092-uftc8inx 410 12 of of IN cord-010092-uftc8inx 410 13 blood blood NN cord-010092-uftc8inx 410 14 banking banking NN cord-010092-uftc8inx 410 15 in in IN cord-010092-uftc8inx 410 16 smaller small JJR cord-010092-uftc8inx 410 17 processes process NNS cord-010092-uftc8inx 410 18 . . . cord-010092-uftc8inx 411 1 This this DT cord-010092-uftc8inx 411 2 adds add VBZ cord-010092-uftc8inx 411 3 the the DT cord-010092-uftc8inx 411 4 possibility possibility NN cord-010092-uftc8inx 411 5 for for IN cord-010092-uftc8inx 411 6 identifying identify VBG cord-010092-uftc8inx 411 7 best good JJS cord-010092-uftc8inx 411 8 of of IN cord-010092-uftc8inx 411 9 breed breed NN cord-010092-uftc8inx 411 10 or or CC cord-010092-uftc8inx 411 11 best good JJS cord-010092-uftc8inx 411 12 of of IN cord-010092-uftc8inx 411 13 suite suite NN cord-010092-uftc8inx 411 14 vendors vendor NNS cord-010092-uftc8inx 411 15 , , , cord-010092-uftc8inx 411 16 instead instead RB cord-010092-uftc8inx 411 17 of of IN cord-010092-uftc8inx 411 18 relying rely VBG cord-010092-uftc8inx 411 19 on on IN cord-010092-uftc8inx 411 20 single single JJ cord-010092-uftc8inx 411 21 vendor vendor NN cord-010092-uftc8inx 411 22 IT it NN cord-010092-uftc8inx 411 23 solutions solution NNS cord-010092-uftc8inx 411 24 . . . cord-010092-uftc8inx 412 1 Furthermore furthermore RB cord-010092-uftc8inx 412 2 it -PRON- PRP cord-010092-uftc8inx 412 3 is be VBZ cord-010092-uftc8inx 412 4 a a DT cord-010092-uftc8inx 412 5 call call NN cord-010092-uftc8inx 412 6 for for IN cord-010092-uftc8inx 412 7 more more JJR cord-010092-uftc8inx 412 8 research research NN cord-010092-uftc8inx 412 9 in in IN cord-010092-uftc8inx 412 10 the the DT cord-010092-uftc8inx 412 11 field field NN cord-010092-uftc8inx 412 12 of of IN cord-010092-uftc8inx 412 13 vendor vendor NN cord-010092-uftc8inx 412 14 selection selection NN cord-010092-uftc8inx 412 15 strategies strategy NNS cord-010092-uftc8inx 412 16 which which WDT cord-010092-uftc8inx 412 17 this this DT cord-010092-uftc8inx 412 18 study study NN cord-010092-uftc8inx 412 19 did do VBD cord-010092-uftc8inx 412 20 n't not RB cord-010092-uftc8inx 412 21 succeed succeed VB cord-010092-uftc8inx 412 22 in in IN cord-010092-uftc8inx 412 23 identifying identify VBG cord-010092-uftc8inx 412 24 . . . cord-010092-uftc8inx 413 1 2D-07 2d-07 CD cord-010092-uftc8inx 413 2 - - SYM cord-010092-uftc8inx 413 3 02 02 CD cord-010092-uftc8inx 413 4 APPLYING apply VBG cord-010092-uftc8inx 413 5 DRONES drone NNS cord-010092-uftc8inx 413 6 TO to IN cord-010092-uftc8inx 413 7 SUPPLY supply VB cord-010092-uftc8inx 413 8 BLOOD blood NN cord-010092-uftc8inx 413 9 TO to IN cord-010092-uftc8inx 413 10 REMOTE remote NN cord-010092-uftc8inx 413 11 AREAS area NNS cord-010092-uftc8inx 413 12 : : : cord-010092-uftc8inx 413 13 RWANDA RWANDA NNP cord-010092-uftc8inx 413 14 'S 'S NNP cord-010092-uftc8inx 413 15 EXPERIENCE EXPERIENCE NNP cord-010092-uftc8inx 413 16 Biomedical Biomedical NNP cord-010092-uftc8inx 413 17 Services Services NNPS cord-010092-uftc8inx 413 18 , , , cord-010092-uftc8inx 413 19 Rwanda Rwanda NNP cord-010092-uftc8inx 413 20 - - HYPH cord-010092-uftc8inx 413 21 Ministry Ministry NNP cord-010092-uftc8inx 413 22 of of IN cord-010092-uftc8inx 413 23 Health Health NNP cord-010092-uftc8inx 413 24 - - HYPH cord-010092-uftc8inx 413 25 National National NNP cord-010092-uftc8inx 413 26 Blood Blood NNP cord-010092-uftc8inx 413 27 Services Services NNPS cord-010092-uftc8inx 413 28 , , , cord-010092-uftc8inx 413 29 Kigali Kigali NNP cord-010092-uftc8inx 413 30 , , , cord-010092-uftc8inx 414 1 Rwanda Rwanda NNP cord-010092-uftc8inx 414 2 Background Background NNP cord-010092-uftc8inx 414 3 : : : cord-010092-uftc8inx 415 1 In in IN cord-010092-uftc8inx 415 2 Rwanda Rwanda NNP cord-010092-uftc8inx 415 3 , , , cord-010092-uftc8inx 415 4 blood blood NN cord-010092-uftc8inx 415 5 transfusion transfusion NN cord-010092-uftc8inx 415 6 services service NNS cord-010092-uftc8inx 415 7 started start VBD cord-010092-uftc8inx 415 8 in in IN cord-010092-uftc8inx 415 9 1976 1976 CD cord-010092-uftc8inx 415 10 . . . cord-010092-uftc8inx 416 1 During during IN cord-010092-uftc8inx 416 2 the the DT cord-010092-uftc8inx 416 3 1994 1994 CD cord-010092-uftc8inx 416 4 genocide genocide NN cord-010092-uftc8inx 416 5 against against IN cord-010092-uftc8inx 416 6 the the DT cord-010092-uftc8inx 416 7 Tutsis Tutsis NNP cord-010092-uftc8inx 416 8 almost almost RB cord-010092-uftc8inx 416 9 all all PDT cord-010092-uftc8inx 416 10 the the DT cord-010092-uftc8inx 416 11 socioeconomic socioeconomic JJ cord-010092-uftc8inx 416 12 fabric fabric NN cord-010092-uftc8inx 416 13 of of IN cord-010092-uftc8inx 416 14 Rwanda Rwanda NNP cord-010092-uftc8inx 416 15 was be VBD cord-010092-uftc8inx 416 16 destroyed destroy VBN cord-010092-uftc8inx 416 17 as as RB cord-010092-uftc8inx 416 18 well well RB cord-010092-uftc8inx 416 19 as as IN cord-010092-uftc8inx 416 20 its -PRON- PRP$ cord-010092-uftc8inx 416 21 health health NN cord-010092-uftc8inx 416 22 infrastructure infrastructure NN cord-010092-uftc8inx 416 23 . . . cord-010092-uftc8inx 417 1 The the DT cord-010092-uftc8inx 417 2 healthcare healthcare NN cord-010092-uftc8inx 417 3 system system NN cord-010092-uftc8inx 417 4 was be VBD cord-010092-uftc8inx 417 5 suffering suffer VBG cord-010092-uftc8inx 417 6 in in IN cord-010092-uftc8inx 417 7 its -PRON- PRP$ cord-010092-uftc8inx 417 8 aftermath aftermath NN cord-010092-uftc8inx 417 9 , , , cord-010092-uftc8inx 417 10 and and CC cord-010092-uftc8inx 417 11 there there EX cord-010092-uftc8inx 417 12 were be VBD cord-010092-uftc8inx 417 13 health health NN cord-010092-uftc8inx 417 14 inequalities inequality NNS cord-010092-uftc8inx 417 15 between between IN cord-010092-uftc8inx 417 16 urban urban JJ cord-010092-uftc8inx 417 17 and and CC cord-010092-uftc8inx 417 18 rural rural JJ cord-010092-uftc8inx 417 19 areas area NNS cord-010092-uftc8inx 417 20 , , , cord-010092-uftc8inx 417 21 including include VBG cord-010092-uftc8inx 417 22 access access NN cord-010092-uftc8inx 417 23 to to IN cord-010092-uftc8inx 417 24 blood blood NN cord-010092-uftc8inx 417 25 for for IN cord-010092-uftc8inx 417 26 transfusion transfusion NN cord-010092-uftc8inx 417 27 . . . cord-010092-uftc8inx 418 1 From from IN cord-010092-uftc8inx 418 2 1995 1995 CD cord-010092-uftc8inx 418 3 , , , cord-010092-uftc8inx 418 4 the the DT cord-010092-uftc8inx 418 5 government government NN cord-010092-uftc8inx 418 6 started start VBD cord-010092-uftc8inx 418 7 to to TO cord-010092-uftc8inx 418 8 rebuild rebuild VB cord-010092-uftc8inx 418 9 all all DT cord-010092-uftc8inx 418 10 courses course NNS cord-010092-uftc8inx 418 11 of of IN cord-010092-uftc8inx 418 12 life life NN cord-010092-uftc8inx 418 13 including include VBG cord-010092-uftc8inx 418 14 the the DT cord-010092-uftc8inx 418 15 health health NN cord-010092-uftc8inx 418 16 system system NN cord-010092-uftc8inx 418 17 and and CC cord-010092-uftc8inx 418 18 the the DT cord-010092-uftc8inx 418 19 blood blood NN cord-010092-uftc8inx 418 20 service service NN cord-010092-uftc8inx 418 21 in in IN cord-010092-uftc8inx 418 22 particular particular JJ cord-010092-uftc8inx 418 23 . . . cord-010092-uftc8inx 419 1 The the DT cord-010092-uftc8inx 419 2 National National NNP cord-010092-uftc8inx 419 3 Center Center NNP cord-010092-uftc8inx 419 4 for for IN cord-010092-uftc8inx 419 5 Blood Blood NNP cord-010092-uftc8inx 419 6 Transfusion Transfusion NNP cord-010092-uftc8inx 419 7 ( ( -LRB- cord-010092-uftc8inx 419 8 NCBT NCBT NNP cord-010092-uftc8inx 419 9 ) ) -RRB- cord-010092-uftc8inx 419 10 was be VBD cord-010092-uftc8inx 419 11 then then RB cord-010092-uftc8inx 419 12 mandated mandate VBN cord-010092-uftc8inx 419 13 to to TO cord-010092-uftc8inx 419 14 provide provide VB cord-010092-uftc8inx 419 15 safe safe JJ cord-010092-uftc8inx 419 16 , , , cord-010092-uftc8inx 419 17 effective effective JJ cord-010092-uftc8inx 419 18 and and CC cord-010092-uftc8inx 419 19 adequate adequate JJ cord-010092-uftc8inx 419 20 blood blood NN cord-010092-uftc8inx 419 21 and and CC cord-010092-uftc8inx 419 22 blood blood NN cord-010092-uftc8inx 419 23 components component NNS cord-010092-uftc8inx 419 24 to to IN cord-010092-uftc8inx 419 25 all all DT cord-010092-uftc8inx 419 26 patients patient NNS cord-010092-uftc8inx 419 27 in in IN cord-010092-uftc8inx 419 28 need need NN cord-010092-uftc8inx 419 29 . . . cord-010092-uftc8inx 420 1 This this DT cord-010092-uftc8inx 420 2 was be VBD cord-010092-uftc8inx 420 3 pivotal pivotal JJ cord-010092-uftc8inx 420 4 in in IN cord-010092-uftc8inx 420 5 achieving achieve VBG cord-010092-uftc8inx 420 6 health health NN cord-010092-uftc8inx 420 7 related relate VBN cord-010092-uftc8inx 420 8 MDGs MDGs NNP cord-010092-uftc8inx 420 9 4 4 CD cord-010092-uftc8inx 420 10 , , , cord-010092-uftc8inx 420 11 5 5 CD cord-010092-uftc8inx 420 12 and and CC cord-010092-uftc8inx 420 13 6 6 CD cord-010092-uftc8inx 420 14 . . . cord-010092-uftc8inx 421 1 Today today NN cord-010092-uftc8inx 421 2 , , , cord-010092-uftc8inx 421 3 Rwanda Rwanda NNP cord-010092-uftc8inx 421 4 has have VBZ cord-010092-uftc8inx 421 5 an an DT cord-010092-uftc8inx 421 6 ambitious ambitious JJ cord-010092-uftc8inx 421 7 vision vision NN cord-010092-uftc8inx 421 8 to to TO cord-010092-uftc8inx 421 9 put put VB cord-010092-uftc8inx 421 10 all all DT cord-010092-uftc8inx 421 11 12 12 CD cord-010092-uftc8inx 421 12 million million CD cord-010092-uftc8inx 421 13 citizens citizen NNS cord-010092-uftc8inx 421 14 within within IN cord-010092-uftc8inx 421 15 30 30 CD cord-010092-uftc8inx 421 16 minutes minute NNS cord-010092-uftc8inx 421 17 of of IN cord-010092-uftc8inx 421 18 any any DT cord-010092-uftc8inx 421 19 essential essential JJ cord-010092-uftc8inx 421 20 medical medical JJ cord-010092-uftc8inx 421 21 product product NN cord-010092-uftc8inx 421 22 . . . cord-010092-uftc8inx 422 1 While while IN cord-010092-uftc8inx 422 2 every every DT cord-010092-uftc8inx 422 3 second second JJ cord-010092-uftc8inx 422 4 matters matter NNS cord-010092-uftc8inx 422 5 in in IN cord-010092-uftc8inx 422 6 emergency emergency NN cord-010092-uftc8inx 422 7 management management NN cord-010092-uftc8inx 422 8 , , , cord-010092-uftc8inx 422 9 the the DT cord-010092-uftc8inx 422 10 use use NN cord-010092-uftc8inx 422 11 of of IN cord-010092-uftc8inx 422 12 Drones Drones NNPS cord-010092-uftc8inx 422 13 was be VBD cord-010092-uftc8inx 422 14 the the DT cord-010092-uftc8inx 422 15 perfect perfect JJ cord-010092-uftc8inx 422 16 solution solution NN cord-010092-uftc8inx 422 17 to to IN cord-010092-uftc8inx 422 18 many many JJ cord-010092-uftc8inx 422 19 of of IN cord-010092-uftc8inx 422 20 the the DT cord-010092-uftc8inx 422 21 last last JJ cord-010092-uftc8inx 422 22 mile mile NN cord-010092-uftc8inx 422 23 challenges challenge NNS cord-010092-uftc8inx 422 24 that that WDT cord-010092-uftc8inx 422 25 have have VBP cord-010092-uftc8inx 422 26 been be VBN cord-010092-uftc8inx 422 27 traditionally traditionally RB cord-010092-uftc8inx 422 28 difficult difficult JJ cord-010092-uftc8inx 422 29 to to TO cord-010092-uftc8inx 422 30 overcome overcome VB cord-010092-uftc8inx 422 31 . . . cord-010092-uftc8inx 423 1 It -PRON- PRP cord-010092-uftc8inx 423 2 is be VBZ cord-010092-uftc8inx 423 3 impossible impossible JJ cord-010092-uftc8inx 423 4 to to TO cord-010092-uftc8inx 423 5 forecast forecast VB cord-010092-uftc8inx 423 6 accurately accurately RB cord-010092-uftc8inx 423 7 down down RB cord-010092-uftc8inx 423 8 to to IN cord-010092-uftc8inx 423 9 the the DT cord-010092-uftc8inx 423 10 need need NN cord-010092-uftc8inx 423 11 of of IN cord-010092-uftc8inx 423 12 a a DT cord-010092-uftc8inx 423 13 single single JJ cord-010092-uftc8inx 423 14 patient patient NN cord-010092-uftc8inx 423 15 . . . cord-010092-uftc8inx 424 1 The the DT cord-010092-uftc8inx 424 2 Government Government NNP cord-010092-uftc8inx 424 3 has have VBZ cord-010092-uftc8inx 424 4 provided provide VBN cord-010092-uftc8inx 424 5 an an DT cord-010092-uftc8inx 424 6 easy easy JJ cord-010092-uftc8inx 424 7 solution solution NN cord-010092-uftc8inx 424 8 by by IN cord-010092-uftc8inx 424 9 centralizing centralize VBG cord-010092-uftc8inx 424 10 supply supply NN cord-010092-uftc8inx 424 11 and and CC cord-010092-uftc8inx 424 12 providing provide VBG cord-010092-uftc8inx 424 13 on on IN cord-010092-uftc8inx 424 14 - - HYPH cord-010092-uftc8inx 424 15 demand demand NN cord-010092-uftc8inx 424 16 , , , cord-010092-uftc8inx 424 17 emergency emergency NN cord-010092-uftc8inx 424 18 medical medical JJ cord-010092-uftc8inx 424 19 deliveries delivery NNS cord-010092-uftc8inx 424 20 by by IN cord-010092-uftc8inx 424 21 drone drone NN cord-010092-uftc8inx 424 22 . . . cord-010092-uftc8inx 425 1 Doctors doctor NNS cord-010092-uftc8inx 425 2 are be VBP cord-010092-uftc8inx 425 3 now now RB cord-010092-uftc8inx 425 4 empowered empower VBN cord-010092-uftc8inx 425 5 to to TO cord-010092-uftc8inx 425 6 provide provide VB cord-010092-uftc8inx 425 7 the the DT cord-010092-uftc8inx 425 8 quality quality NN cord-010092-uftc8inx 425 9 care care NN cord-010092-uftc8inx 425 10 with with IN cord-010092-uftc8inx 425 11 all all PDT cord-010092-uftc8inx 425 12 the the DT cord-010092-uftc8inx 425 13 supplies supply NNS cord-010092-uftc8inx 425 14 on on IN cord-010092-uftc8inx 425 15 hand hand NN cord-010092-uftc8inx 425 16 , , , cord-010092-uftc8inx 425 17 patients patient NNS cord-010092-uftc8inx 425 18 can can MD cord-010092-uftc8inx 425 19 now now RB cord-010092-uftc8inx 425 20 be be VB cord-010092-uftc8inx 425 21 treated treat VBN cord-010092-uftc8inx 425 22 close close RB cord-010092-uftc8inx 425 23 to to IN cord-010092-uftc8inx 425 24 home home NN cord-010092-uftc8inx 425 25 , , , cord-010092-uftc8inx 425 26 and and CC cord-010092-uftc8inx 425 27 we -PRON- PRP cord-010092-uftc8inx 425 28 eliminate eliminate VBP cord-010092-uftc8inx 425 29 waste waste NN cord-010092-uftc8inx 425 30 from from IN cord-010092-uftc8inx 425 31 potential potential JJ cord-010092-uftc8inx 425 32 overstocking overstocking NN cord-010092-uftc8inx 425 33 when when WRB cord-010092-uftc8inx 425 34 health health NN cord-010092-uftc8inx 425 35 workers worker NNS cord-010092-uftc8inx 425 36 know know VBP cord-010092-uftc8inx 425 37 that that IN cord-010092-uftc8inx 425 38 they -PRON- PRP cord-010092-uftc8inx 425 39 have have VBP cord-010092-uftc8inx 425 40 a a DT cord-010092-uftc8inx 425 41 quick quick JJ cord-010092-uftc8inx 425 42 and and CC cord-010092-uftc8inx 425 43 reliable reliable JJ cord-010092-uftc8inx 425 44 source source NN cord-010092-uftc8inx 425 45 of of IN cord-010092-uftc8inx 425 46 supply supply NN cord-010092-uftc8inx 425 47 . . . cord-010092-uftc8inx 426 1 Description description NN cord-010092-uftc8inx 426 2 : : : cord-010092-uftc8inx 426 3 In in IN cord-010092-uftc8inx 426 4 2016 2016 CD cord-010092-uftc8inx 426 5 , , , cord-010092-uftc8inx 426 6 the the DT cord-010092-uftc8inx 426 7 Government Government NNP cord-010092-uftc8inx 426 8 of of IN cord-010092-uftc8inx 426 9 Rwanda Rwanda NNP cord-010092-uftc8inx 426 10 started start VBD cord-010092-uftc8inx 426 11 to to TO cord-010092-uftc8inx 426 12 operate operate VB cord-010092-uftc8inx 426 13 the the DT cord-010092-uftc8inx 426 14 world world NN cord-010092-uftc8inx 426 15 's 's POS cord-010092-uftc8inx 426 16 first first JJ cord-010092-uftc8inx 426 17 national national JJ cord-010092-uftc8inx 426 18 drone drone NN cord-010092-uftc8inx 426 19 delivery delivery NN cord-010092-uftc8inx 426 20 program program NN cord-010092-uftc8inx 426 21 for for IN cord-010092-uftc8inx 426 22 blood blood NN cord-010092-uftc8inx 426 23 and and CC cord-010092-uftc8inx 426 24 other other JJ cord-010092-uftc8inx 426 25 lifesaving lifesaving JJ cord-010092-uftc8inx 426 26 medical medical JJ cord-010092-uftc8inx 426 27 products product NNS cord-010092-uftc8inx 426 28 . . . cord-010092-uftc8inx 427 1 These these DT cord-010092-uftc8inx 427 2 drones drone NNS cord-010092-uftc8inx 427 3 can can MD cord-010092-uftc8inx 427 4 carry carry VB cord-010092-uftc8inx 427 5 two two CD cord-010092-uftc8inx 427 6 to to TO cord-010092-uftc8inx 427 7 six six CD cord-010092-uftc8inx 427 8 units unit NNS cord-010092-uftc8inx 427 9 of of IN cord-010092-uftc8inx 427 10 blood blood NN cord-010092-uftc8inx 427 11 at at IN cord-010092-uftc8inx 427 12 a a DT cord-010092-uftc8inx 427 13 time time NN cord-010092-uftc8inx 427 14 and and CC cord-010092-uftc8inx 427 15 deliver deliver VB cord-010092-uftc8inx 427 16 in in IN cord-010092-uftc8inx 427 17 15 15 CD cord-010092-uftc8inx 427 18 -45 -45 NNP cord-010092-uftc8inx 427 19 minutes minute NNS cord-010092-uftc8inx 427 20 depending depend VBG cord-010092-uftc8inx 427 21 on on IN cord-010092-uftc8inx 427 22 a a DT cord-010092-uftc8inx 427 23 hospital hospital NN cord-010092-uftc8inx 427 24 's 's POS cord-010092-uftc8inx 427 25 location location NN cord-010092-uftc8inx 427 26 . . . cord-010092-uftc8inx 428 1 The the DT cord-010092-uftc8inx 428 2 average average JJ cord-010092-uftc8inx 428 3 duration duration NN cord-010092-uftc8inx 428 4 was be VBD cord-010092-uftc8inx 428 5 between between IN cord-010092-uftc8inx 428 6 2 2 CD cord-010092-uftc8inx 428 7 -4 -4 CD cord-010092-uftc8inx 428 8 hours hour NNS cord-010092-uftc8inx 428 9 round round JJ cord-010092-uftc8inx 428 10 trip trip NN cord-010092-uftc8inx 428 11 with with IN cord-010092-uftc8inx 428 12 the the DT cord-010092-uftc8inx 428 13 vehicle vehicle NN cord-010092-uftc8inx 428 14 system system NN cord-010092-uftc8inx 428 15 , , , cord-010092-uftc8inx 428 16 before before IN cord-010092-uftc8inx 428 17 the the DT cord-010092-uftc8inx 428 18 use use NN cord-010092-uftc8inx 428 19 of of IN cord-010092-uftc8inx 428 20 Drones Drones NNPS cord-010092-uftc8inx 428 21 . . . cord-010092-uftc8inx 429 1 Drones drone NNS cord-010092-uftc8inx 429 2 currently currently RB cord-010092-uftc8inx 429 3 deliver deliver VBP cord-010092-uftc8inx 429 4 blood blood NN cord-010092-uftc8inx 429 5 to to IN cord-010092-uftc8inx 429 6 25 25 CD cord-010092-uftc8inx 429 7 health health NN cord-010092-uftc8inx 429 8 facilities facility NNS cord-010092-uftc8inx 429 9 throughout throughout IN cord-010092-uftc8inx 429 10 the the DT cord-010092-uftc8inx 429 11 country country NN cord-010092-uftc8inx 429 12 and and CC cord-010092-uftc8inx 429 13 are be VBP cord-010092-uftc8inx 429 14 set set VBN cord-010092-uftc8inx 429 15 to to TO cord-010092-uftc8inx 429 16 reach reach VB cord-010092-uftc8inx 429 17 90 90 CD cord-010092-uftc8inx 429 18 % % NN cord-010092-uftc8inx 429 19 of of IN cord-010092-uftc8inx 429 20 transfusing transfuse VBG cord-010092-uftc8inx 429 21 health health NN cord-010092-uftc8inx 429 22 facilities facility NNS cord-010092-uftc8inx 429 23 outside outside IN cord-010092-uftc8inx 429 24 Kigali Kigali NNP cord-010092-uftc8inx 429 25 by by IN cord-010092-uftc8inx 429 26 the the DT cord-010092-uftc8inx 429 27 end end NN cord-010092-uftc8inx 429 28 of of IN cord-010092-uftc8inx 429 29 the the DT cord-010092-uftc8inx 429 30 year year NN cord-010092-uftc8inx 429 31 . . . cord-010092-uftc8inx 430 1 Within within IN cord-010092-uftc8inx 430 2 the the DT cord-010092-uftc8inx 430 3 first first JJ cord-010092-uftc8inx 430 4 year year NN cord-010092-uftc8inx 430 5 , , , cord-010092-uftc8inx 430 6 Healthcare Healthcare NNP cord-010092-uftc8inx 430 7 workers worker NNS cord-010092-uftc8inx 430 8 saved save VBD cord-010092-uftc8inx 430 9 an an DT cord-010092-uftc8inx 430 10 average average NN cord-010092-uftc8inx 430 11 of of IN cord-010092-uftc8inx 430 12 3.1 3.1 CD cord-010092-uftc8inx 430 13 hours hour NNS cord-010092-uftc8inx 430 14 per per IN cord-010092-uftc8inx 430 15 delivery delivery NN cord-010092-uftc8inx 430 16 and and CC cord-010092-uftc8inx 430 17 a a DT cord-010092-uftc8inx 430 18 total total NN cord-010092-uftc8inx 430 19 of of IN cord-010092-uftc8inx 430 20 10,115 10,115 CD cord-010092-uftc8inx 430 21 hours hour NNS cord-010092-uftc8inx 430 22 of of IN cord-010092-uftc8inx 430 23 lost lose VBN cord-010092-uftc8inx 430 24 time time NN cord-010092-uftc8inx 430 25 on on IN cord-010092-uftc8inx 430 26 road road NN cord-010092-uftc8inx 430 27 pick pick NN cord-010092-uftc8inx 430 28 up up RP cord-010092-uftc8inx 430 29 they -PRON- PRP cord-010092-uftc8inx 430 30 could could MD cord-010092-uftc8inx 430 31 instead instead RB cord-010092-uftc8inx 430 32 dedicate dedicate VB cord-010092-uftc8inx 430 33 to to TO cord-010092-uftc8inx 430 34 patient patient JJ cord-010092-uftc8inx 430 35 care care NN cord-010092-uftc8inx 430 36 . . . cord-010092-uftc8inx 431 1 By by IN cord-010092-uftc8inx 431 2 March March NNP cord-010092-uftc8inx 431 3 2019 2019 CD cord-010092-uftc8inx 431 4 , , , cord-010092-uftc8inx 431 5 over over IN cord-010092-uftc8inx 431 6 11,000 11,000 CD cord-010092-uftc8inx 431 7 deliveries delivery NNS cord-010092-uftc8inx 431 8 have have VBP cord-010092-uftc8inx 431 9 been be VBN cord-010092-uftc8inx 431 10 made make VBN cord-010092-uftc8inx 431 11 , , , cord-010092-uftc8inx 431 12 with with IN cord-010092-uftc8inx 431 13 30 30 CD cord-010092-uftc8inx 431 14 % % NN cord-010092-uftc8inx 431 15 of of IN cord-010092-uftc8inx 431 16 those those DT cord-010092-uftc8inx 431 17 being be VBG cord-010092-uftc8inx 431 18 emergency emergency NN cord-010092-uftc8inx 431 19 deliveries delivery NNS cord-010092-uftc8inx 431 20 . . . cord-010092-uftc8inx 432 1 A a DT cord-010092-uftc8inx 432 2 total total NN cord-010092-uftc8inx 432 3 of of IN cord-010092-uftc8inx 432 4 more more JJR cord-010092-uftc8inx 432 5 than than IN cord-010092-uftc8inx 432 6 19,500 19,500 CD cord-010092-uftc8inx 432 7 blood blood NN cord-010092-uftc8inx 432 8 units unit NNS cord-010092-uftc8inx 432 9 have have VBP cord-010092-uftc8inx 432 10 been be VBN cord-010092-uftc8inx 432 11 delivered deliver VBN cord-010092-uftc8inx 432 12 . . . cord-010092-uftc8inx 433 1 In in IN cord-010092-uftc8inx 433 2 February February NNP cord-010092-uftc8inx 433 3 2018 2018 CD cord-010092-uftc8inx 433 4 , , , cord-010092-uftc8inx 433 5 Zipline Zipline NNP cord-010092-uftc8inx 433 6 obtained obtain VBD cord-010092-uftc8inx 433 7 the the DT cord-010092-uftc8inx 433 8 highest high JJS cord-010092-uftc8inx 433 9 rating rating NN cord-010092-uftc8inx 433 10 from from IN cord-010092-uftc8inx 433 11 the the DT cord-010092-uftc8inx 433 12 health health NN cord-010092-uftc8inx 433 13 facilities facility NNS cord-010092-uftc8inx 433 14 being be VBG cord-010092-uftc8inx 433 15 served serve VBN cord-010092-uftc8inx 433 16 in in IN cord-010092-uftc8inx 433 17 a a DT cord-010092-uftc8inx 433 18 performance performance NN cord-010092-uftc8inx 433 19 evaluation evaluation NN cord-010092-uftc8inx 433 20 conducted conduct VBN cord-010092-uftc8inx 433 21 by by IN cord-010092-uftc8inx 433 22 the the DT cord-010092-uftc8inx 433 23 National National NNP cord-010092-uftc8inx 433 24 Center Center NNP cord-010092-uftc8inx 433 25 for for IN cord-010092-uftc8inx 433 26 Blood Blood NNP cord-010092-uftc8inx 433 27 Transfusion Transfusion NNP cord-010092-uftc8inx 433 28 . . . cord-010092-uftc8inx 434 1 When when WRB cord-010092-uftc8inx 434 2 a a DT cord-010092-uftc8inx 434 3 doctor doctor NN cord-010092-uftc8inx 434 4 or or CC cord-010092-uftc8inx 434 5 medical medical JJ cord-010092-uftc8inx 434 6 staffer staffer NN cord-010092-uftc8inx 434 7 needs need VBZ cord-010092-uftc8inx 434 8 blood blood NN cord-010092-uftc8inx 434 9 , , , cord-010092-uftc8inx 434 10 they -PRON- PRP cord-010092-uftc8inx 434 11 place place VBP cord-010092-uftc8inx 434 12 an an DT cord-010092-uftc8inx 434 13 order order NN cord-010092-uftc8inx 434 14 through through IN cord-010092-uftc8inx 434 15 the the DT cord-010092-uftc8inx 434 16 Hemovigilance Hemovigilance NNP cord-010092-uftc8inx 434 17 order order NN cord-010092-uftc8inx 434 18 portal portal NN cord-010092-uftc8inx 434 19 . . . cord-010092-uftc8inx 435 1 They -PRON- PRP cord-010092-uftc8inx 435 2 are be VBP cord-010092-uftc8inx 435 3 then then RB cord-010092-uftc8inx 435 4 sent send VBN cord-010092-uftc8inx 435 5 a a DT cord-010092-uftc8inx 435 6 confirmation confirmation NN cord-010092-uftc8inx 435 7 message message NN cord-010092-uftc8inx 435 8 saying say VBG cord-010092-uftc8inx 435 9 a a DT cord-010092-uftc8inx 435 10 drone drone NN cord-010092-uftc8inx 435 11 is be VBZ cord-010092-uftc8inx 435 12 on on IN cord-010092-uftc8inx 435 13 its -PRON- PRP$ cord-010092-uftc8inx 435 14 way way NN cord-010092-uftc8inx 435 15 . . . cord-010092-uftc8inx 436 1 The the DT cord-010092-uftc8inx 436 2 drone drone NN cord-010092-uftc8inx 436 3 flies fly VBZ cord-010092-uftc8inx 436 4 to to IN cord-010092-uftc8inx 436 5 the the DT cord-010092-uftc8inx 436 6 health health NN cord-010092-uftc8inx 436 7 facility facility NN cord-010092-uftc8inx 436 8 at at IN cord-010092-uftc8inx 436 9 up up IN cord-010092-uftc8inx 436 10 to to TO cord-010092-uftc8inx 436 11 100 100 CD cord-010092-uftc8inx 436 12 km km NNS cord-010092-uftc8inx 436 13 / / SYM cord-010092-uftc8inx 436 14 h h NN cord-010092-uftc8inx 436 15 . . . cord-010092-uftc8inx 437 1 When when WRB cord-010092-uftc8inx 437 2 it -PRON- PRP cord-010092-uftc8inx 437 3 is be VBZ cord-010092-uftc8inx 437 4 within within IN cord-010092-uftc8inx 437 5 five five CD cord-010092-uftc8inx 437 6 minutes minute NNS cord-010092-uftc8inx 437 7 of of IN cord-010092-uftc8inx 437 8 the the DT cord-010092-uftc8inx 437 9 destination destination NN cord-010092-uftc8inx 437 10 , , , cord-010092-uftc8inx 437 11 the the DT cord-010092-uftc8inx 437 12 medical medical JJ cord-010092-uftc8inx 437 13 staffer staffer NN cord-010092-uftc8inx 437 14 receives receive VBZ cord-010092-uftc8inx 437 15 a a DT cord-010092-uftc8inx 437 16 notification notification NN cord-010092-uftc8inx 437 17 . . . cord-010092-uftc8inx 438 1 The the DT cord-010092-uftc8inx 438 2 drone drone NN cord-010092-uftc8inx 438 3 then then RB cord-010092-uftc8inx 438 4 drops drop VBZ cord-010092-uftc8inx 438 5 the the DT cord-010092-uftc8inx 438 6 package package NN cord-010092-uftc8inx 438 7 , , , cord-010092-uftc8inx 438 8 attached attach VBN cord-010092-uftc8inx 438 9 to to IN cord-010092-uftc8inx 438 10 a a DT cord-010092-uftc8inx 438 11 parachute parachute NN cord-010092-uftc8inx 438 12 , , , cord-010092-uftc8inx 438 13 into into IN cord-010092-uftc8inx 438 14 a a DT cord-010092-uftc8inx 438 15 special special JJ cord-010092-uftc8inx 438 16 drop drop NN cord-010092-uftc8inx 438 17 zone zone NN cord-010092-uftc8inx 438 18 . . . cord-010092-uftc8inx 439 1 Conclusion conclusion NN cord-010092-uftc8inx 439 2 : : : cord-010092-uftc8inx 440 1 Supply supply NN cord-010092-uftc8inx 440 2 is be VBZ cord-010092-uftc8inx 440 3 not not RB cord-010092-uftc8inx 440 4 a a DT cord-010092-uftc8inx 440 5 developing develop VBG cord-010092-uftc8inx 440 6 country country NN cord-010092-uftc8inx 440 7 problem problem NN cord-010092-uftc8inx 440 8 , , , cord-010092-uftc8inx 440 9 it -PRON- PRP cord-010092-uftc8inx 440 10 is be VBZ cord-010092-uftc8inx 440 11 a a DT cord-010092-uftc8inx 440 12 global global JJ cord-010092-uftc8inx 440 13 issue issue NN cord-010092-uftc8inx 440 14 . . . cord-010092-uftc8inx 441 1 Rwanda Rwanda NNP cord-010092-uftc8inx 441 2 was be VBD cord-010092-uftc8inx 441 3 just just RB cord-010092-uftc8inx 441 4 the the DT cord-010092-uftc8inx 441 5 first first JJ cord-010092-uftc8inx 441 6 one one CD cord-010092-uftc8inx 441 7 to to TO cord-010092-uftc8inx 441 8 recognize recognize VB cord-010092-uftc8inx 441 9 the the DT cord-010092-uftc8inx 441 10 potential potential NN cord-010092-uftc8inx 441 11 of of IN cord-010092-uftc8inx 441 12 this this DT cord-010092-uftc8inx 441 13 technology technology NN cord-010092-uftc8inx 441 14 and and CC cord-010092-uftc8inx 441 15 decided decide VBD cord-010092-uftc8inx 441 16 to to TO cord-010092-uftc8inx 441 17 do do VB cord-010092-uftc8inx 441 18 something something NN cord-010092-uftc8inx 441 19 about about IN cord-010092-uftc8inx 441 20 it -PRON- PRP cord-010092-uftc8inx 441 21 first first RB cord-010092-uftc8inx 441 22 and and CC cord-010092-uftc8inx 441 23 fast fast RB cord-010092-uftc8inx 441 24 , , , cord-010092-uftc8inx 441 25 to to TO cord-010092-uftc8inx 441 26 ensure ensure VB cord-010092-uftc8inx 441 27 access access NN cord-010092-uftc8inx 441 28 to to IN cord-010092-uftc8inx 441 29 universal universal JJ cord-010092-uftc8inx 441 30 access access NN cord-010092-uftc8inx 441 31 to to IN cord-010092-uftc8inx 441 32 all all DT cord-010092-uftc8inx 441 33 blood blood NN cord-010092-uftc8inx 441 34 products product NNS cord-010092-uftc8inx 441 35 . . . cord-010092-uftc8inx 442 1 2D-07 2d-07 CD cord-010092-uftc8inx 442 2 - - SYM cord-010092-uftc8inx 442 3 03 03 CD cord-010092-uftc8inx 442 4 Scottish Scottish NNP cord-010092-uftc8inx 442 5 National National NNP cord-010092-uftc8inx 442 6 Blood Blood NNP cord-010092-uftc8inx 442 7 Transfusion Transfusion NNP cord-010092-uftc8inx 442 8 Service Service NNP cord-010092-uftc8inx 442 9 , , , cord-010092-uftc8inx 442 10 Edinburgh Edinburgh NNP cord-010092-uftc8inx 442 11 , , , cord-010092-uftc8inx 442 12 United United NNP cord-010092-uftc8inx 442 13 Kingdom Kingdom NNP cord-010092-uftc8inx 442 14 Supporting support VBG cord-010092-uftc8inx 442 15 the the DT cord-010092-uftc8inx 442 16 provision provision NN cord-010092-uftc8inx 442 17 of of IN cord-010092-uftc8inx 442 18 viable viable JJ cord-010092-uftc8inx 442 19 transfusion transfusion NN cord-010092-uftc8inx 442 20 services service NNS cord-010092-uftc8inx 442 21 in in IN cord-010092-uftc8inx 442 22 remote remote JJ cord-010092-uftc8inx 442 23 / / SYM cord-010092-uftc8inx 442 24 rural rural JJ cord-010092-uftc8inx 442 25 areas area NNS cord-010092-uftc8inx 442 26 is be VBZ cord-010092-uftc8inx 442 27 more more JJR cord-010092-uftc8inx 442 28 than than IN cord-010092-uftc8inx 442 29 just just RB cord-010092-uftc8inx 442 30 a a DT cord-010092-uftc8inx 442 31 geographical geographical JJ cord-010092-uftc8inx 442 32 challenge challenge NN cord-010092-uftc8inx 442 33 . . . cord-010092-uftc8inx 443 1 Limited limited JJ cord-010092-uftc8inx 443 2 qualified qualified JJ cord-010092-uftc8inx 443 3 blood blood NN cord-010092-uftc8inx 443 4 bank bank NN cord-010092-uftc8inx 443 5 resource resource NN cord-010092-uftc8inx 443 6 ; ; , cord-010092-uftc8inx 443 7 small small JJ cord-010092-uftc8inx 443 8 throughput throughput NN cord-010092-uftc8inx 443 9 volumes volume NNS cord-010092-uftc8inx 443 10 ; ; , cord-010092-uftc8inx 443 11 increased increase VBN cord-010092-uftc8inx 443 12 regulation regulation NN cord-010092-uftc8inx 443 13 are be VBP cord-010092-uftc8inx 443 14 only only RB cord-010092-uftc8inx 443 15 three three CD cord-010092-uftc8inx 443 16 of of IN cord-010092-uftc8inx 443 17 the the DT cord-010092-uftc8inx 443 18 additional additional JJ cord-010092-uftc8inx 443 19 factors factor NNS cord-010092-uftc8inx 443 20 combining combine VBG cord-010092-uftc8inx 443 21 to to TO cord-010092-uftc8inx 443 22 threaten threaten VB cord-010092-uftc8inx 443 23 safe safe JJ cord-010092-uftc8inx 443 24 and and CC cord-010092-uftc8inx 443 25 sustainable sustainable JJ cord-010092-uftc8inx 443 26 transfusion transfusion NN cord-010092-uftc8inx 443 27 service service NN cord-010092-uftc8inx 443 28 delivery delivery NN cord-010092-uftc8inx 443 29 . . . cord-010092-uftc8inx 444 1 Inventory inventory NN cord-010092-uftc8inx 444 2 management management NN cord-010092-uftc8inx 444 3 and and CC cord-010092-uftc8inx 444 4 out out IN cord-010092-uftc8inx 444 5 of of IN cord-010092-uftc8inx 444 6 hours hour NNS cord-010092-uftc8inx 444 7 service service NN cord-010092-uftc8inx 444 8 provision provision NN cord-010092-uftc8inx 444 9 were be VBD cord-010092-uftc8inx 444 10 identified identify VBN cord-010092-uftc8inx 444 11 as as IN cord-010092-uftc8inx 444 12 essential essential JJ cord-010092-uftc8inx 444 13 areas area NNS cord-010092-uftc8inx 444 14 where where WRB cord-010092-uftc8inx 444 15 it -PRON- PRP cord-010092-uftc8inx 444 16 was be VBD cord-010092-uftc8inx 444 17 thought think VBN cord-010092-uftc8inx 444 18 that that IN cord-010092-uftc8inx 444 19 technology technology NN cord-010092-uftc8inx 444 20 , , , cord-010092-uftc8inx 444 21 in in IN cord-010092-uftc8inx 444 22 the the DT cord-010092-uftc8inx 444 23 form form NN cord-010092-uftc8inx 444 24 of of IN cord-010092-uftc8inx 444 25 a a DT cord-010092-uftc8inx 444 26 remotely remotely RB cord-010092-uftc8inx 444 27 controlled control VBN cord-010092-uftc8inx 444 28 blood blood NN cord-010092-uftc8inx 444 29 fridge fridge NN cord-010092-uftc8inx 444 30 , , , cord-010092-uftc8inx 444 31 could could MD cord-010092-uftc8inx 444 32 provide provide VB cord-010092-uftc8inx 444 33 a a DT cord-010092-uftc8inx 444 34 key key JJ cord-010092-uftc8inx 444 35 element element NN cord-010092-uftc8inx 444 36 of of IN cord-010092-uftc8inx 444 37 the the DT cord-010092-uftc8inx 444 38 overall overall JJ cord-010092-uftc8inx 444 39 solution solution NN cord-010092-uftc8inx 444 40 . . . cord-010092-uftc8inx 445 1 A a DT cord-010092-uftc8inx 445 2 Radio Radio NNP cord-010092-uftc8inx 445 3 Frequency Frequency NNP cord-010092-uftc8inx 445 4 Identification Identification NNP cord-010092-uftc8inx 445 5 ( ( -LRB- cord-010092-uftc8inx 445 6 RFID RFID NNP cord-010092-uftc8inx 445 7 ) ) -RRB- cord-010092-uftc8inx 445 8 fridge fridge NN cord-010092-uftc8inx 445 9 racking racking NN cord-010092-uftc8inx 445 10 system system NN cord-010092-uftc8inx 445 11 was be VBD cord-010092-uftc8inx 445 12 installed instal VBN cord-010092-uftc8inx 445 13 in in IN cord-010092-uftc8inx 445 14 a a DT cord-010092-uftc8inx 445 15 standard standard JJ cord-010092-uftc8inx 445 16 blood blood NN cord-010092-uftc8inx 445 17 bank bank NN cord-010092-uftc8inx 445 18 fridge fridge NN cord-010092-uftc8inx 445 19 and and CC cord-010092-uftc8inx 445 20 connected connect VBN cord-010092-uftc8inx 445 21 to to IN cord-010092-uftc8inx 445 22 the the DT cord-010092-uftc8inx 445 23 Laboratory Laboratory NNP cord-010092-uftc8inx 445 24 Information Information NNP cord-010092-uftc8inx 445 25 Management Management NNP cord-010092-uftc8inx 445 26 System System NNP cord-010092-uftc8inx 445 27 ( ( -LRB- cord-010092-uftc8inx 445 28 LIMS LIMS NNP cord-010092-uftc8inx 445 29 ) ) -RRB- cord-010092-uftc8inx 445 30 common common JJ cord-010092-uftc8inx 445 31 to to IN cord-010092-uftc8inx 445 32 both both CC cord-010092-uftc8inx 445 33 the the DT cord-010092-uftc8inx 445 34 remote remote JJ cord-010092-uftc8inx 445 35 and and CC cord-010092-uftc8inx 445 36 central central JJ cord-010092-uftc8inx 445 37 blood blood NN cord-010092-uftc8inx 445 38 bank bank NN cord-010092-uftc8inx 445 39 . . . cord-010092-uftc8inx 446 1 The the DT cord-010092-uftc8inx 446 2 central central JJ cord-010092-uftc8inx 446 3 blood blood NN cord-010092-uftc8inx 446 4 bank bank NN cord-010092-uftc8inx 446 5 was be VBD cord-010092-uftc8inx 446 6 enabled enable VBN cord-010092-uftc8inx 446 7 to to TO cord-010092-uftc8inx 446 8 test test VB cord-010092-uftc8inx 446 9 patient patient NN cord-010092-uftc8inx 446 10 samples sample NNS cord-010092-uftc8inx 446 11 from from IN cord-010092-uftc8inx 446 12 the the DT cord-010092-uftc8inx 446 13 remote remote JJ cord-010092-uftc8inx 446 14 laboratory laboratory NN cord-010092-uftc8inx 446 15 , , , cord-010092-uftc8inx 446 16 identify identify VB cord-010092-uftc8inx 446 17 components component NNS cord-010092-uftc8inx 446 18 located locate VBN cord-010092-uftc8inx 446 19 in in IN cord-010092-uftc8inx 446 20 the the DT cord-010092-uftc8inx 446 21 remote remote JJ cord-010092-uftc8inx 446 22 fridge fridge NN cord-010092-uftc8inx 446 23 suitable suitable JJ cord-010092-uftc8inx 446 24 for for IN cord-010092-uftc8inx 446 25 the the DT cord-010092-uftc8inx 446 26 patient patient NN cord-010092-uftc8inx 446 27 and and CC cord-010092-uftc8inx 446 28 allow allow VB cord-010092-uftc8inx 446 29 correct correct JJ cord-010092-uftc8inx 446 30 component component NN cord-010092-uftc8inx 446 31 issue issue NN cord-010092-uftc8inx 446 32 , , , cord-010092-uftc8inx 446 33 even even RB cord-010092-uftc8inx 446 34 when when WRB cord-010092-uftc8inx 446 35 qualified qualified JJ cord-010092-uftc8inx 446 36 staff staff NN cord-010092-uftc8inx 446 37 were be VBD cord-010092-uftc8inx 446 38 unavailable unavailable JJ cord-010092-uftc8inx 446 39 in in IN cord-010092-uftc8inx 446 40 the the DT cord-010092-uftc8inx 446 41 remote remote JJ cord-010092-uftc8inx 446 42 laboratory laboratory NN cord-010092-uftc8inx 446 43 . . . cord-010092-uftc8inx 447 1 Testing testing NN cord-010092-uftc8inx 447 2 has have VBZ cord-010092-uftc8inx 447 3 concluded conclude VBN cord-010092-uftc8inx 447 4 that that IN cord-010092-uftc8inx 447 5 installation installation NN cord-010092-uftc8inx 447 6 of of IN cord-010092-uftc8inx 447 7 remote remote JJ cord-010092-uftc8inx 447 8 fridge fridge NN cord-010092-uftc8inx 447 9 management management NN cord-010092-uftc8inx 447 10 can can MD cord-010092-uftc8inx 447 11 play play VB cord-010092-uftc8inx 447 12 a a DT cord-010092-uftc8inx 447 13 major major JJ cord-010092-uftc8inx 447 14 role role NN cord-010092-uftc8inx 447 15 in in IN cord-010092-uftc8inx 447 16 helping help VBG cord-010092-uftc8inx 447 17 to to TO cord-010092-uftc8inx 447 18 maintain maintain VB cord-010092-uftc8inx 447 19 a a DT cord-010092-uftc8inx 447 20 remote remote JJ cord-010092-uftc8inx 447 21 inventory inventory NN cord-010092-uftc8inx 447 22 permitting permit VBG cord-010092-uftc8inx 447 23 patient patient JJ cord-010092-uftc8inx 447 24 compatible compatible JJ cord-010092-uftc8inx 447 25 components component NNS cord-010092-uftc8inx 447 26 to to TO cord-010092-uftc8inx 447 27 be be VB cord-010092-uftc8inx 447 28 issued issue VBN cord-010092-uftc8inx 447 29 . . . cord-010092-uftc8inx 448 1 By by IN cord-010092-uftc8inx 448 2 sustaining sustain VBG cord-010092-uftc8inx 448 3 transfusion transfusion NN cord-010092-uftc8inx 448 4 services service NNS cord-010092-uftc8inx 448 5 in in IN cord-010092-uftc8inx 448 6 remote remote JJ cord-010092-uftc8inx 448 7 communities community NNS cord-010092-uftc8inx 448 8 we -PRON- PRP cord-010092-uftc8inx 448 9 can can MD cord-010092-uftc8inx 448 10 avoid avoid VB cord-010092-uftc8inx 448 11 transportation transportation NN cord-010092-uftc8inx 448 12 of of IN cord-010092-uftc8inx 448 13 patients patient NNS cord-010092-uftc8inx 448 14 who who WP cord-010092-uftc8inx 448 15 require require VBP cord-010092-uftc8inx 448 16 transfusion transfusion NN cord-010092-uftc8inx 448 17 support support NN cord-010092-uftc8inx 448 18 to to IN cord-010092-uftc8inx 448 19 locations location NNS cord-010092-uftc8inx 448 20 miles mile NNS cord-010092-uftc8inx 448 21 from from IN cord-010092-uftc8inx 448 22 home home NN cord-010092-uftc8inx 448 23 . . . cord-010092-uftc8inx 449 1 Antibodies antibody NNS cord-010092-uftc8inx 449 2 to to IN cord-010092-uftc8inx 449 3 HNA-1b HNA-1b NNP cord-010092-uftc8inx 449 4 , , , cord-010092-uftc8inx 449 5 FcgRIIIb fcgriiib JJ cord-010092-uftc8inx 449 6 and and CC cord-010092-uftc8inx 449 7 HNA-2 HNA-2 NNP cord-010092-uftc8inx 449 8 have have VBP cord-010092-uftc8inx 449 9 been be VBN cord-010092-uftc8inx 449 10 reported report VBN cord-010092-uftc8inx 449 11 , , , cord-010092-uftc8inx 449 12 too too RB cord-010092-uftc8inx 449 13 . . . cord-010092-uftc8inx 450 1 Neonatal neonatal JJ cord-010092-uftc8inx 450 2 alloimmune alloimmune NNP cord-010092-uftc8inx 450 3 neutropenia neutropenia NN cord-010092-uftc8inx 451 1 results result NNS cord-010092-uftc8inx 451 2 from from IN cord-010092-uftc8inx 451 3 maternal maternal JJ cord-010092-uftc8inx 451 4 antibodies antibody NNS cord-010092-uftc8inx 451 5 transferred transfer VBN cord-010092-uftc8inx 451 6 transplacentally transplacentally RB cord-010092-uftc8inx 451 7 to to IN cord-010092-uftc8inx 451 8 the the DT cord-010092-uftc8inx 451 9 fetus fetus NN cord-010092-uftc8inx 451 10 and and CC cord-010092-uftc8inx 451 11 is be VBZ cord-010092-uftc8inx 451 12 caused cause VBN cord-010092-uftc8inx 451 13 by by IN cord-010092-uftc8inx 451 14 all all DT cord-010092-uftc8inx 451 15 known know VBN cord-010092-uftc8inx 451 16 HNA HNA NNP cord-010092-uftc8inx 451 17 - - HYPH cord-010092-uftc8inx 451 18 antibody antibody NN cord-010092-uftc8inx 451 19 specificities specificity NNS cord-010092-uftc8inx 451 20 , , , cord-010092-uftc8inx 451 21 i.e. i.e. FW cord-010092-uftc8inx 451 22 HNA-1a HNA-1a NNP cord-010092-uftc8inx 451 23 , , , cord-010092-uftc8inx 451 24 -1b -1b NNPS cord-010092-uftc8inx 451 25 , , , cord-010092-uftc8inx 451 26 -1c -1c NNP cord-010092-uftc8inx 451 27 , , , cord-010092-uftc8inx 451 28 -1d -1d UH cord-010092-uftc8inx 451 29 , , , cord-010092-uftc8inx 451 30 HNA-2 HNA-2 NNP cord-010092-uftc8inx 451 31 , , , cord-010092-uftc8inx 451 32 HNA-3a HNA-3a NNP cord-010092-uftc8inx 451 33 , , , cord-010092-uftc8inx 451 34 -3b -3b UH cord-010092-uftc8inx 451 35 , , , cord-010092-uftc8inx 451 36 HNA-4a HNA-4a NNP cord-010092-uftc8inx 451 37 , , , cord-010092-uftc8inx 451 38 -4b -4b ADD cord-010092-uftc8inx 451 39 and and CC cord-010092-uftc8inx 451 40 HNA-5a HNA-5a NNP cord-010092-uftc8inx 451 41 specificity specificity NN cord-010092-uftc8inx 451 42 . . . cord-010092-uftc8inx 452 1 HNA HNA NNP cord-010092-uftc8inx 452 2 and and CC cord-010092-uftc8inx 452 3 HLA HLA NNP cord-010092-uftc8inx 452 4 antibodies antibody NNS cord-010092-uftc8inx 452 5 can can MD cord-010092-uftc8inx 452 6 induce induce VB cord-010092-uftc8inx 452 7 mild mild JJ cord-010092-uftc8inx 452 8 febrile febrile JJ cord-010092-uftc8inx 452 9 transfusion transfusion NN cord-010092-uftc8inx 452 10 reactions reaction NNS cord-010092-uftc8inx 452 11 and and CC cord-010092-uftc8inx 452 12 TRALI TRALI NNP cord-010092-uftc8inx 452 13 . . . cord-010092-uftc8inx 453 1 Since since IN cord-010092-uftc8inx 453 2 the the DT cord-010092-uftc8inx 453 3 introduction introduction NN cord-010092-uftc8inx 453 4 of of IN cord-010092-uftc8inx 453 5 the the DT cord-010092-uftc8inx 453 6 male male JJ cord-010092-uftc8inx 453 7 only only JJ cord-010092-uftc8inx 453 8 plasma plasma NN cord-010092-uftc8inx 453 9 strategy strategy NN cord-010092-uftc8inx 453 10 , , , cord-010092-uftc8inx 453 11 in in IN cord-010092-uftc8inx 453 12 many many JJ cord-010092-uftc8inx 453 13 countries country NNS cord-010092-uftc8inx 453 14 the the DT cord-010092-uftc8inx 453 15 TRALI TRALI NNP cord-010092-uftc8inx 453 16 incidence incidence NN cord-010092-uftc8inx 453 17 decreased decrease VBD cord-010092-uftc8inx 453 18 but but CC cord-010092-uftc8inx 453 19 it -PRON- PRP cord-010092-uftc8inx 453 20 is be VBZ cord-010092-uftc8inx 453 21 still still RB cord-010092-uftc8inx 453 22 one one CD cord-010092-uftc8inx 453 23 of of IN cord-010092-uftc8inx 453 24 the the DT cord-010092-uftc8inx 453 25 most most RBS cord-010092-uftc8inx 453 26 common common JJ cord-010092-uftc8inx 453 27 causes cause NNS cord-010092-uftc8inx 453 28 of of IN cord-010092-uftc8inx 453 29 severe severe JJ cord-010092-uftc8inx 453 30 transfusion transfusion NN cord-010092-uftc8inx 453 31 reactions reaction NNS cord-010092-uftc8inx 453 32 . . . cord-010092-uftc8inx 454 1 Especially especially RB cord-010092-uftc8inx 454 2 HNA-3a hna-3a JJ cord-010092-uftc8inx 454 3 antibody antibody NN cord-010092-uftc8inx 454 4 containing contain VBG cord-010092-uftc8inx 454 5 plasma plasma NN cord-010092-uftc8inx 454 6 from from IN cord-010092-uftc8inx 454 7 female female JJ cord-010092-uftc8inx 454 8 donors donor NNS cord-010092-uftc8inx 454 9 is be VBZ cord-010092-uftc8inx 454 10 responsible responsible JJ cord-010092-uftc8inx 454 11 for for IN cord-010092-uftc8inx 454 12 severe severe JJ cord-010092-uftc8inx 454 13 or or CC cord-010092-uftc8inx 454 14 even even RB cord-010092-uftc8inx 454 15 fatal fatal JJ cord-010092-uftc8inx 454 16 reactions reaction NNS cord-010092-uftc8inx 454 17 . . . cord-010092-uftc8inx 455 1 But but CC cord-010092-uftc8inx 455 2 also also RB cord-010092-uftc8inx 455 3 HNA-1a HNA-1a NNP cord-010092-uftc8inx 455 4 , , , cord-010092-uftc8inx 455 5 -1b -1b NNPS cord-010092-uftc8inx 455 6 , , , cord-010092-uftc8inx 455 7 HNA-2 HNA-2 NNP cord-010092-uftc8inx 455 8 and and CC cord-010092-uftc8inx 455 9 HLA HLA NNP cord-010092-uftc8inx 455 10 class class NN cord-010092-uftc8inx 456 1 I -PRON- PRP cord-010092-uftc8inx 456 2 and and CC cord-010092-uftc8inx 456 3 class class NN cord-010092-uftc8inx 456 4 II ii CD cord-010092-uftc8inx 456 5 antibodies antibody NNS cord-010092-uftc8inx 456 6 were be VBD cord-010092-uftc8inx 456 7 reported report VBN cord-010092-uftc8inx 456 8 . . . cord-010092-uftc8inx 457 1 The the DT cord-010092-uftc8inx 457 2 latter latter JJ cord-010092-uftc8inx 457 3 activate activate VBP cord-010092-uftc8inx 457 4 monocytes monocyte NNS cord-010092-uftc8inx 457 5 to to TO cord-010092-uftc8inx 457 6 secrete secrete VB cord-010092-uftc8inx 457 7 soluble soluble JJ cord-010092-uftc8inx 457 8 factors factor NNS cord-010092-uftc8inx 457 9 that that WDT cord-010092-uftc8inx 457 10 act act VBP cord-010092-uftc8inx 457 11 on on IN cord-010092-uftc8inx 457 12 the the DT cord-010092-uftc8inx 457 13 primed primed JJ cord-010092-uftc8inx 457 14 neutrophils neutrophil NNS cord-010092-uftc8inx 457 15 in in IN cord-010092-uftc8inx 457 16 the the DT cord-010092-uftc8inx 457 17 narrow narrow JJ cord-010092-uftc8inx 457 18 lung lung NN cord-010092-uftc8inx 457 19 capillaries capillary NNS cord-010092-uftc8inx 457 20 . . . cord-010092-uftc8inx 458 1 Laboratory laboratory NN cord-010092-uftc8inx 458 2 testing testing NN cord-010092-uftc8inx 458 3 : : : cord-010092-uftc8inx 459 1 Laboratory laboratory NN cord-010092-uftc8inx 459 2 work work NN cord-010092-uftc8inx 459 3 - - HYPH cord-010092-uftc8inx 459 4 up up NN cord-010092-uftc8inx 459 5 requires require VBZ cord-010092-uftc8inx 459 6 the the DT cord-010092-uftc8inx 459 7 knowledge knowledge NN cord-010092-uftc8inx 459 8 of of IN cord-010092-uftc8inx 459 9 the the DT cord-010092-uftc8inx 459 10 patient patient NN cord-010092-uftc8inx 459 11 's 's POS cord-010092-uftc8inx 459 12 clinical clinical JJ cord-010092-uftc8inx 459 13 condition condition NN cord-010092-uftc8inx 459 14 and and CC cord-010092-uftc8inx 459 15 the the DT cord-010092-uftc8inx 459 16 methods method NNS cord-010092-uftc8inx 459 17 that that WDT cord-010092-uftc8inx 459 18 are be VBP cord-010092-uftc8inx 459 19 appropriate appropriate JJ cord-010092-uftc8inx 459 20 to to TO cord-010092-uftc8inx 459 21 detect detect VB cord-010092-uftc8inx 459 22 the the DT cord-010092-uftc8inx 459 23 relevant relevant JJ cord-010092-uftc8inx 459 24 antibodies antibody NNS cord-010092-uftc8inx 459 25 . . . cord-010092-uftc8inx 460 1 The the DT cord-010092-uftc8inx 460 2 classical classical JJ cord-010092-uftc8inx 460 3 granulocyte granulocyte NN cord-010092-uftc8inx 460 4 agglutination agglutination NN cord-010092-uftc8inx 460 5 test test NN cord-010092-uftc8inx 460 6 ( ( -LRB- cord-010092-uftc8inx 460 7 GAT GAT NNP cord-010092-uftc8inx 460 8 ) ) -RRB- cord-010092-uftc8inx 460 9 in in IN cord-010092-uftc8inx 460 10 combination combination NN cord-010092-uftc8inx 460 11 with with IN cord-010092-uftc8inx 460 12 the the DT cord-010092-uftc8inx 460 13 granulocyte granulocyte NN cord-010092-uftc8inx 460 14 indirect indirect JJ cord-010092-uftc8inx 460 15 immunofluorescence immunofluorescence NN cord-010092-uftc8inx 460 16 test test NN cord-010092-uftc8inx 460 17 ( ( -LRB- cord-010092-uftc8inx 460 18 GIFT gift NN cord-010092-uftc8inx 460 19 ) ) -RRB- cord-010092-uftc8inx 460 20 can can MD cord-010092-uftc8inx 460 21 detect detect VB cord-010092-uftc8inx 460 22 nearly nearly RB cord-010092-uftc8inx 460 23 all all DT cord-010092-uftc8inx 460 24 relevant relevant JJ cord-010092-uftc8inx 460 25 antibodies antibody NNS cord-010092-uftc8inx 460 26 . . . cord-010092-uftc8inx 461 1 HNA-1 HNA-1 NNP cord-010092-uftc8inx 461 2 , , , cord-010092-uftc8inx 461 3 -2 -2 NNP cord-010092-uftc8inx 461 4 , , , cord-010092-uftc8inx 461 5 -4 -4 NNP cord-010092-uftc8inx 461 6 , , , cord-010092-uftc8inx 461 7 -5 -5 NNP cord-010092-uftc8inx 461 8 and and CC cord-010092-uftc8inx 461 9 HLA HLA NNP cord-010092-uftc8inx 461 10 class class NN cord-010092-uftc8inx 462 1 I -PRON- PRP cord-010092-uftc8inx 462 2 antibodies antibody NNS cord-010092-uftc8inx 462 3 are be VBP cord-010092-uftc8inx 462 4 clearly clearly RB cord-010092-uftc8inx 462 5 detectable detectable JJ cord-010092-uftc8inx 462 6 in in IN cord-010092-uftc8inx 462 7 the the DT cord-010092-uftc8inx 462 8 GIFT gift NN cord-010092-uftc8inx 462 9 while while IN cord-010092-uftc8inx 462 10 HNA-3 HNA-3 NNP cord-010092-uftc8inx 462 11 antibodies antibody NNS cord-010092-uftc8inx 462 12 strongly strongly RB cord-010092-uftc8inx 462 13 agglutinate agglutinate VBP cord-010092-uftc8inx 462 14 neutrophils neutrophil NNS cord-010092-uftc8inx 462 15 in in IN cord-010092-uftc8inx 462 16 the the DT cord-010092-uftc8inx 462 17 GAT GAT NNP cord-010092-uftc8inx 462 18 . . . cord-010092-uftc8inx 463 1 The the DT cord-010092-uftc8inx 463 2 monoclonal monoclonal JJ cord-010092-uftc8inx 463 3 antibody antibody NN cord-010092-uftc8inx 463 4 - - HYPH cord-010092-uftc8inx 463 5 specific specific JJ cord-010092-uftc8inx 463 6 immobilization immobilization NN cord-010092-uftc8inx 463 7 of of IN cord-010092-uftc8inx 463 8 granulocyte granulocyte NN cord-010092-uftc8inx 463 9 antigens antigen NNS cord-010092-uftc8inx 463 10 ( ( -LRB- cord-010092-uftc8inx 463 11 MAIGA MAIGA NNP cord-010092-uftc8inx 463 12 ) ) -RRB- cord-010092-uftc8inx 463 13 test test NN cord-010092-uftc8inx 463 14 detects detect VBZ cord-010092-uftc8inx 463 15 all all DT cord-010092-uftc8inx 463 16 HNAantibodies hnaantibodie NNS cord-010092-uftc8inx 463 17 except except IN cord-010092-uftc8inx 463 18 for for IN cord-010092-uftc8inx 463 19 HNA-3 HNA-3 NNP cord-010092-uftc8inx 463 20 with with IN cord-010092-uftc8inx 463 21 high high JJ cord-010092-uftc8inx 463 22 glycoprotein glycoprotein NN cord-010092-uftc8inx 463 23 specificity specificity NN cord-010092-uftc8inx 463 24 and and CC cord-010092-uftc8inx 463 25 sensitivity sensitivity NN cord-010092-uftc8inx 463 26 but but CC cord-010092-uftc8inx 463 27 is be VBZ cord-010092-uftc8inx 463 28 time time NN cord-010092-uftc8inx 463 29 consuming consume VBG cord-010092-uftc8inx 463 30 and and CC cord-010092-uftc8inx 463 31 requires require VBZ cord-010092-uftc8inx 463 32 highly highly RB cord-010092-uftc8inx 463 33 skilled skilled JJ cord-010092-uftc8inx 463 34 personnel personnel NNS cord-010092-uftc8inx 463 35 . . . cord-010092-uftc8inx 464 1 For for IN cord-010092-uftc8inx 464 2 TRALI TRALI NNP cord-010092-uftc8inx 464 3 diagnostics diagnostic NNS cord-010092-uftc8inx 464 4 laboratory laboratory NN cord-010092-uftc8inx 464 5 testing testing NN cord-010092-uftc8inx 464 6 is be VBZ cord-010092-uftc8inx 464 7 completed complete VBN cord-010092-uftc8inx 464 8 by by IN cord-010092-uftc8inx 464 9 methods method NNS cord-010092-uftc8inx 464 10 like like IN cord-010092-uftc8inx 464 11 the the DT cord-010092-uftc8inx 464 12 indirect indirect JJ cord-010092-uftc8inx 464 13 lymphocyte lymphocyte NN cord-010092-uftc8inx 464 14 immunofluorescence immunofluorescence NN cord-010092-uftc8inx 464 15 test test NN cord-010092-uftc8inx 464 16 ( ( -LRB- cord-010092-uftc8inx 464 17 LIFT lift VB cord-010092-uftc8inx 464 18 ) ) -RRB- cord-010092-uftc8inx 464 19 or or CC cord-010092-uftc8inx 464 20 ELISA ELISA NNP cord-010092-uftc8inx 464 21 for for IN cord-010092-uftc8inx 464 22 HLA HLA NNP cord-010092-uftc8inx 464 23 class class NN cord-010092-uftc8inx 465 1 I -PRON- PRP cord-010092-uftc8inx 465 2 antibodies antibody NNS cord-010092-uftc8inx 465 3 and and CC cord-010092-uftc8inx 465 4 HLA HLA NNP cord-010092-uftc8inx 465 5 class class NN cord-010092-uftc8inx 465 6 II II NNP cord-010092-uftc8inx 465 7 specific specific JJ cord-010092-uftc8inx 465 8 ELISAs elisa NNS cord-010092-uftc8inx 465 9 . . . cord-010092-uftc8inx 466 1 Since since IN cord-010092-uftc8inx 466 2 several several JJ cord-010092-uftc8inx 466 3 years year NNS cord-010092-uftc8inx 466 4 fluorescent fluorescent NN cord-010092-uftc8inx 466 5 bead bead NN cord-010092-uftc8inx 466 6 based base VBN cord-010092-uftc8inx 466 7 assays assay NNS cord-010092-uftc8inx 466 8 ( ( -LRB- cord-010092-uftc8inx 466 9 Luminex Luminex NNP cord-010092-uftc8inx 466 10 ) ) -RRB- cord-010092-uftc8inx 466 11 enable enable VB cord-010092-uftc8inx 466 12 faster fast JJR cord-010092-uftc8inx 466 13 and and CC cord-010092-uftc8inx 466 14 more more RBR cord-010092-uftc8inx 466 15 automated automated JJ cord-010092-uftc8inx 466 16 HNA HNA NNP cord-010092-uftc8inx 466 17 antibody antibody NN cord-010092-uftc8inx 466 18 detection detection NN cord-010092-uftc8inx 466 19 but but CC cord-010092-uftc8inx 466 20 to to IN cord-010092-uftc8inx 466 21 date date NN cord-010092-uftc8inx 466 22 not not RB cord-010092-uftc8inx 466 23 all all DT cord-010092-uftc8inx 466 24 specificities specificity NNS cord-010092-uftc8inx 466 25 , , , cord-010092-uftc8inx 466 26 especially especially RB cord-010092-uftc8inx 466 27 HNA-3 HNA-3 NNP cord-010092-uftc8inx 466 28 , , , cord-010092-uftc8inx 466 29 can can MD cord-010092-uftc8inx 466 30 be be VB cord-010092-uftc8inx 466 31 reliably reliably RB cord-010092-uftc8inx 466 32 detected detect VBN cord-010092-uftc8inx 466 33 so so IN cord-010092-uftc8inx 466 34 that that IN cord-010092-uftc8inx 466 35 still still RB cord-010092-uftc8inx 466 36 the the DT cord-010092-uftc8inx 466 37 classical classical JJ cord-010092-uftc8inx 466 38 GIFT gift NN cord-010092-uftc8inx 466 39 and and CC cord-010092-uftc8inx 466 40 GAT GAT NNP cord-010092-uftc8inx 466 41 have have VB cord-010092-uftc8inx 466 42 to to TO cord-010092-uftc8inx 466 43 complete complete VB cord-010092-uftc8inx 466 44 the the DT cord-010092-uftc8inx 466 45 methodological methodological JJ cord-010092-uftc8inx 466 46 spectrum spectrum NN cord-010092-uftc8inx 466 47 . . . cord-010092-uftc8inx 467 1 Serological serological JJ cord-010092-uftc8inx 467 2 typing type VBG cord-010092-uftc8inx 467 3 today today NN cord-010092-uftc8inx 467 4 is be VBZ cord-010092-uftc8inx 467 5 mostly mostly RB cord-010092-uftc8inx 467 6 reduced reduce VBN cord-010092-uftc8inx 467 7 to to IN cord-010092-uftc8inx 467 8 the the DT cord-010092-uftc8inx 467 9 determination determination NN cord-010092-uftc8inx 467 10 of of IN cord-010092-uftc8inx 467 11 HNA-2 HNA-2 NNP cord-010092-uftc8inx 467 12 in in IN cord-010092-uftc8inx 467 13 the the DT cord-010092-uftc8inx 467 14 GIFT gift NN cord-010092-uftc8inx 467 15 because because IN cord-010092-uftc8inx 467 16 the the DT cord-010092-uftc8inx 467 17 molecular molecular JJ cord-010092-uftc8inx 467 18 reason reason NN cord-010092-uftc8inx 467 19 for for IN cord-010092-uftc8inx 467 20 the the DT cord-010092-uftc8inx 467 21 HNA-2-null HNA-2-null NNP cord-010092-uftc8inx 467 22 phenotype phenotype NN cord-010092-uftc8inx 467 23 is be VBZ cord-010092-uftc8inx 467 24 not not RB cord-010092-uftc8inx 467 25 completely completely RB cord-010092-uftc8inx 467 26 understood understand VBN cord-010092-uftc8inx 467 27 . . . cord-010092-uftc8inx 468 1 Establishing establish VBG cord-010092-uftc8inx 468 2 only only RB cord-010092-uftc8inx 468 3 one one CD cord-010092-uftc8inx 468 4 PCR PCR NNP cord-010092-uftc8inx 468 5 - - HYPH cord-010092-uftc8inx 468 6 ASP ASP NNP cord-010092-uftc8inx 468 7 reaction reaction NN cord-010092-uftc8inx 468 8 for for IN cord-010092-uftc8inx 468 9 the the DT cord-010092-uftc8inx 468 10 main main JJ cord-010092-uftc8inx 468 11 CD177 cd177 NN cord-010092-uftc8inx 469 1 * * NFP cord-010092-uftc8inx 469 2 787A 787a CD cord-010092-uftc8inx 470 1 > > XX cord-010092-uftc8inx 471 1 T T NNP cord-010092-uftc8inx 471 2 polymorphism polymorphism NN cord-010092-uftc8inx 471 3 would would MD cord-010092-uftc8inx 471 4 comprise comprise VB cord-010092-uftc8inx 471 5 the the DT cord-010092-uftc8inx 471 6 risk risk NN cord-010092-uftc8inx 471 7 to to TO cord-010092-uftc8inx 471 8 miss miss VB cord-010092-uftc8inx 471 9 other other JJ cord-010092-uftc8inx 471 10 molecular molecular JJ cord-010092-uftc8inx 471 11 causes cause NNS cord-010092-uftc8inx 471 12 . . . cord-010092-uftc8inx 472 1 However however RB cord-010092-uftc8inx 472 2 , , , cord-010092-uftc8inx 472 3 for for IN cord-010092-uftc8inx 472 4 all all DT cord-010092-uftc8inx 472 5 other other JJ cord-010092-uftc8inx 472 6 HNA HNA NNP cord-010092-uftc8inx 472 7 allelotyping allelotype VBG cord-010092-uftc8inx 472 8 by by IN cord-010092-uftc8inx 472 9 PCR PCR NNP cord-010092-uftc8inx 472 10 methods method NNS cord-010092-uftc8inx 472 11 is be VBZ cord-010092-uftc8inx 472 12 the the DT cord-010092-uftc8inx 472 13 first first JJ cord-010092-uftc8inx 472 14 choice choice NN cord-010092-uftc8inx 472 15 . . . cord-010092-uftc8inx 473 1 Summary Summary NNP cord-010092-uftc8inx 473 2 / / SYM cord-010092-uftc8inx 473 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 473 4 : : : cord-010092-uftc8inx 474 1 Granulocyte granulocyte NN cord-010092-uftc8inx 474 2 serology serology NN cord-010092-uftc8inx 474 3 still still RB cord-010092-uftc8inx 474 4 today today NN cord-010092-uftc8inx 474 5 is be VBZ cord-010092-uftc8inx 474 6 widely widely RB cord-010092-uftc8inx 474 7 based base VBN cord-010092-uftc8inx 474 8 on on IN cord-010092-uftc8inx 474 9 a a DT cord-010092-uftc8inx 474 10 variety variety NN cord-010092-uftc8inx 474 11 of of IN cord-010092-uftc8inx 474 12 manual manual JJ cord-010092-uftc8inx 474 13 methods method NNS cord-010092-uftc8inx 474 14 and and CC cord-010092-uftc8inx 474 15 will will MD cord-010092-uftc8inx 474 16 be be VB cord-010092-uftc8inx 474 17 reserved reserve VBN cord-010092-uftc8inx 474 18 to to IN cord-010092-uftc8inx 474 19 specialized specialized JJ cord-010092-uftc8inx 474 20 laboratories laboratory NNS cord-010092-uftc8inx 474 21 as as IN cord-010092-uftc8inx 474 22 it -PRON- PRP cord-010092-uftc8inx 474 23 requires require VBZ cord-010092-uftc8inx 474 24 experienced experienced JJ cord-010092-uftc8inx 474 25 laboratory laboratory NN cord-010092-uftc8inx 474 26 staff staff NN cord-010092-uftc8inx 474 27 and and CC cord-010092-uftc8inx 474 28 profound profound JJ cord-010092-uftc8inx 474 29 knowledge knowledge NN cord-010092-uftc8inx 474 30 of of IN cord-010092-uftc8inx 474 31 granulocyte granulocyte NNP cord-010092-uftc8inx 474 32 immunobiology immunobiology NN cord-010092-uftc8inx 474 33 . . . cord-010092-uftc8inx 475 1 2D-08 2d-08 CD cord-010092-uftc8inx 475 2 - - SYM cord-010092-uftc8inx 475 3 02 02 CD cord-010092-uftc8inx 475 4 Norwegian Norwegian NNP cord-010092-uftc8inx 475 5 National National NNP cord-010092-uftc8inx 475 6 Unit Unit NNP cord-010092-uftc8inx 475 7 of of IN cord-010092-uftc8inx 475 8 Platelet Platelet NNP cord-010092-uftc8inx 475 9 Immunology Immunology NNP cord-010092-uftc8inx 475 10 , , , cord-010092-uftc8inx 475 11 Laboratory Laboratory NNP cord-010092-uftc8inx 475 12 Medicine Medicine NNP cord-010092-uftc8inx 475 13 , , , cord-010092-uftc8inx 475 14 University University NNP cord-010092-uftc8inx 475 15 Hospital Hospital NNP cord-010092-uftc8inx 475 16 of of IN cord-010092-uftc8inx 475 17 North North NNP cord-010092-uftc8inx 475 18 Norway Norway NNP cord-010092-uftc8inx 475 19 , , , cord-010092-uftc8inx 475 20 Tromso Tromso NNP cord-010092-uftc8inx 475 21 , , , cord-010092-uftc8inx 476 1 Norway Norway NNP cord-010092-uftc8inx 476 2 Maternal maternal JJ cord-010092-uftc8inx 476 3 alloantibodies alloantibody NNS cord-010092-uftc8inx 476 4 against against IN cord-010092-uftc8inx 476 5 antigens antigen NNS cord-010092-uftc8inx 476 6 on on IN cord-010092-uftc8inx 476 7 human human JJ cord-010092-uftc8inx 476 8 platelets platelet NNS cord-010092-uftc8inx 476 9 can can MD cord-010092-uftc8inx 476 10 cause cause VB cord-010092-uftc8inx 476 11 severe severe JJ cord-010092-uftc8inx 476 12 thrombocytopenia thrombocytopenia NN cord-010092-uftc8inx 476 13 and and CC cord-010092-uftc8inx 476 14 bleeding bleed VBG cord-010092-uftc8inx 476 15 in in IN cord-010092-uftc8inx 476 16 fetus fetus NN cord-010092-uftc8inx 476 17 or or CC cord-010092-uftc8inx 476 18 newborn newborn JJ cord-010092-uftc8inx 476 19 , , , cord-010092-uftc8inx 476 20 identified identify VBN cord-010092-uftc8inx 476 21 as as IN cord-010092-uftc8inx 476 22 Fetal Fetal NNP cord-010092-uftc8inx 476 23 / / SYM cord-010092-uftc8inx 476 24 Neonatal Neonatal NNP cord-010092-uftc8inx 476 25 Alloimmune Alloimmune NNP cord-010092-uftc8inx 476 26 thrombocytopenia thrombocytopenia NN cord-010092-uftc8inx 476 27 ( ( -LRB- cord-010092-uftc8inx 476 28 FNAIT FNAIT NNP cord-010092-uftc8inx 476 29 ) ) -RRB- cord-010092-uftc8inx 476 30 . . . cord-010092-uftc8inx 477 1 Although although IN cord-010092-uftc8inx 477 2 most most JJS cord-010092-uftc8inx 477 3 cases case NNS cord-010092-uftc8inx 477 4 the the DT cord-010092-uftc8inx 477 5 thrombocytopenia thrombocytopenia NN cord-010092-uftc8inx 477 6 is be VBZ cord-010092-uftc8inx 477 7 selfresolving selfresolve VBG cord-010092-uftc8inx 477 8 within within IN cord-010092-uftc8inx 477 9 the the DT cord-010092-uftc8inx 477 10 two two CD cord-010092-uftc8inx 477 11 first first JJ cord-010092-uftc8inx 477 12 weeks week NNS cord-010092-uftc8inx 477 13 of of IN cord-010092-uftc8inx 477 14 life life NN cord-010092-uftc8inx 477 15 , , , cord-010092-uftc8inx 477 16 some some DT cord-010092-uftc8inx 477 17 infants infant NNS cord-010092-uftc8inx 477 18 present present VBP cord-010092-uftc8inx 477 19 bleeding bleed VBG cord-010092-uftc8inx 477 20 symptoms symptom NNS cord-010092-uftc8inx 477 21 and and CC cord-010092-uftc8inx 477 22 thus thus RB cord-010092-uftc8inx 477 23 require require VBP cord-010092-uftc8inx 477 24 platelet platelet NN cord-010092-uftc8inx 477 25 transfusion transfusion NN cord-010092-uftc8inx 477 26 . . . cord-010092-uftc8inx 478 1 A a DT cord-010092-uftc8inx 478 2 set set NN cord-010092-uftc8inx 478 3 of of IN cord-010092-uftc8inx 478 4 laboratory laboratory NN cord-010092-uftc8inx 478 5 analyses analysis NNS cord-010092-uftc8inx 478 6 are be VBP cord-010092-uftc8inx 478 7 required require VBN cord-010092-uftc8inx 478 8 to to TO cord-010092-uftc8inx 478 9 confirm confirm VB cord-010092-uftc8inx 478 10 the the DT cord-010092-uftc8inx 478 11 FNAIT FNAIT NNP cord-010092-uftc8inx 478 12 diagnosis diagnosis NN cord-010092-uftc8inx 478 13 . . . cord-010092-uftc8inx 479 1 In in IN cord-010092-uftc8inx 479 2 addition addition NN cord-010092-uftc8inx 479 3 to to IN cord-010092-uftc8inx 479 4 guiding guide VBG cord-010092-uftc8inx 479 5 compatible compatible JJ cord-010092-uftc8inx 479 6 platelets platelet NNS cord-010092-uftc8inx 479 7 to to IN cord-010092-uftc8inx 479 8 the the DT cord-010092-uftc8inx 479 9 affected affect VBN cord-010092-uftc8inx 479 10 newborn newborn JJ cord-010092-uftc8inx 479 11 , , , cord-010092-uftc8inx 479 12 the the DT cord-010092-uftc8inx 479 13 correct correct JJ cord-010092-uftc8inx 479 14 diagnosis diagnosis NN cord-010092-uftc8inx 479 15 will will MD cord-010092-uftc8inx 479 16 be be VB cord-010092-uftc8inx 479 17 valuable valuable JJ cord-010092-uftc8inx 479 18 to to TO cord-010092-uftc8inx 479 19 assess assess VB cord-010092-uftc8inx 479 20 the the DT cord-010092-uftc8inx 479 21 risk risk NN cord-010092-uftc8inx 479 22 of of IN cord-010092-uftc8inx 479 23 FNAIT FNAIT NNP cord-010092-uftc8inx 479 24 in in IN cord-010092-uftc8inx 479 25 subsequent subsequent JJ cord-010092-uftc8inx 479 26 pregnancies pregnancy NNS cord-010092-uftc8inx 479 27 . . . cord-010092-uftc8inx 480 1 In in IN cord-010092-uftc8inx 480 2 addition addition NN cord-010092-uftc8inx 480 3 , , , cord-010092-uftc8inx 480 4 platelet platelet NN cord-010092-uftc8inx 480 5 alloantibodies alloantibody NNS cord-010092-uftc8inx 480 6 may may MD cord-010092-uftc8inx 480 7 also also RB cord-010092-uftc8inx 480 8 complicate complicate VB cord-010092-uftc8inx 480 9 platelet platelet NN cord-010092-uftc8inx 480 10 transfusions transfusion NNS cord-010092-uftc8inx 480 11 by by IN cord-010092-uftc8inx 480 12 immune immune NN cord-010092-uftc8inx 480 13 - - HYPH cord-010092-uftc8inx 480 14 mediated mediate VBN cord-010092-uftc8inx 480 15 platelet platelet NN cord-010092-uftc8inx 480 16 refractoriness refractoriness NN cord-010092-uftc8inx 480 17 , , , cord-010092-uftc8inx 480 18 and and CC cord-010092-uftc8inx 480 19 require require VB cord-010092-uftc8inx 480 20 proper proper JJ cord-010092-uftc8inx 480 21 identification identification NN cord-010092-uftc8inx 480 22 of of IN cord-010092-uftc8inx 480 23 the the DT cord-010092-uftc8inx 480 24 patient patient NN cord-010092-uftc8inx 480 25 's 's POS cord-010092-uftc8inx 480 26 antibody antibody NN cord-010092-uftc8inx 480 27 specificities specificity NNS cord-010092-uftc8inx 480 28 prior prior RB cord-010092-uftc8inx 480 29 to to IN cord-010092-uftc8inx 480 30 selection selection NN cord-010092-uftc8inx 480 31 of of IN cord-010092-uftc8inx 480 32 donor donor NN cord-010092-uftc8inx 480 33 platelets platelet NNS cord-010092-uftc8inx 480 34 . . . cord-010092-uftc8inx 481 1 The the DT cord-010092-uftc8inx 481 2 algorithm algorithm NN cord-010092-uftc8inx 481 3 for for IN cord-010092-uftc8inx 481 4 laboratory laboratory NN cord-010092-uftc8inx 481 5 investigations investigation NNS cord-010092-uftc8inx 481 6 include include VBP cord-010092-uftc8inx 481 7 both both DT cord-010092-uftc8inx 481 8 serological serological JJ cord-010092-uftc8inx 481 9 and and CC cord-010092-uftc8inx 481 10 molecular molecular JJ cord-010092-uftc8inx 481 11 assays assay NNS cord-010092-uftc8inx 481 12 , , , cord-010092-uftc8inx 481 13 and and CC cord-010092-uftc8inx 481 14 depend depend VB cord-010092-uftc8inx 481 15 on on IN cord-010092-uftc8inx 481 16 the the DT cord-010092-uftc8inx 481 17 objective objective NN cord-010092-uftc8inx 481 18 and and CC cord-010092-uftc8inx 481 19 timing timing NN cord-010092-uftc8inx 481 20 : : : cord-010092-uftc8inx 481 21 whether whether IN cord-010092-uftc8inx 481 22 there there EX cord-010092-uftc8inx 481 23 is be VBZ cord-010092-uftc8inx 481 24 an an DT cord-010092-uftc8inx 481 25 urgent urgent JJ cord-010092-uftc8inx 481 26 need need NN cord-010092-uftc8inx 481 27 for for IN cord-010092-uftc8inx 481 28 platelet platelet NN cord-010092-uftc8inx 481 29 transfusion transfusion NN cord-010092-uftc8inx 481 30 , , , cord-010092-uftc8inx 481 31 follow follow NN cord-010092-uftc8inx 481 32 - - HYPH cord-010092-uftc8inx 481 33 up up NN cord-010092-uftc8inx 481 34 of of IN cord-010092-uftc8inx 481 35 a a DT cord-010092-uftc8inx 481 36 pregnancy pregnancy NN cord-010092-uftc8inx 481 37 with with IN cord-010092-uftc8inx 481 38 known know VBN cord-010092-uftc8inx 481 39 risk risk NN cord-010092-uftc8inx 481 40 , , , cord-010092-uftc8inx 481 41 or or CC cord-010092-uftc8inx 481 42 to to TO cord-010092-uftc8inx 481 43 do do VB cord-010092-uftc8inx 481 44 full full JJ cord-010092-uftc8inx 481 45 - - HYPH cord-010092-uftc8inx 481 46 scale scale NN cord-010092-uftc8inx 481 47 laboratory laboratory NN cord-010092-uftc8inx 481 48 testing testing NN cord-010092-uftc8inx 481 49 to to TO cord-010092-uftc8inx 481 50 confirm confirm VB cord-010092-uftc8inx 481 51 diagnosis diagnosis NN cord-010092-uftc8inx 481 52 . . . cord-010092-uftc8inx 482 1 Molecular molecular JJ cord-010092-uftc8inx 482 2 genotyping genotyping NN cord-010092-uftc8inx 482 3 should should MD cord-010092-uftc8inx 482 4 include include VB cord-010092-uftc8inx 482 5 all all DT cord-010092-uftc8inx 482 6 HPA HPA NNP cord-010092-uftc8inx 482 7 systems system NNS cord-010092-uftc8inx 482 8 relevant relevant JJ cord-010092-uftc8inx 482 9 for for IN cord-010092-uftc8inx 482 10 the the DT cord-010092-uftc8inx 482 11 local local JJ cord-010092-uftc8inx 482 12 population population NN cord-010092-uftc8inx 482 13 ( ( -LRB- cord-010092-uftc8inx 482 14 in in IN cord-010092-uftc8inx 482 15 Caucasians Caucasians NNPS cord-010092-uftc8inx 482 16 HPA-1 HPA-1 NNP cord-010092-uftc8inx 482 17 , , , cord-010092-uftc8inx 482 18 -2 -2 NNP cord-010092-uftc8inx 482 19 , , , cord-010092-uftc8inx 482 20 -3 -3 NNP cord-010092-uftc8inx 482 21 , , , cord-010092-uftc8inx 482 22 -5 -5 NNP cord-010092-uftc8inx 482 23 and and CC cord-010092-uftc8inx 482 24 -15 -15 LS cord-010092-uftc8inx 482 25 ) ) -RRB- cord-010092-uftc8inx 482 26 , , , cord-010092-uftc8inx 482 27 preferably preferably RB cord-010092-uftc8inx 482 28 with with IN cord-010092-uftc8inx 482 29 optional optional JJ cord-010092-uftc8inx 482 30 extended extended JJ cord-010092-uftc8inx 482 31 panels panel NNS cord-010092-uftc8inx 482 32 for for IN cord-010092-uftc8inx 482 33 systems system NNS cord-010092-uftc8inx 482 34 for for IN cord-010092-uftc8inx 482 35 low low JJ cord-010092-uftc8inx 482 36 frequency frequency NN cord-010092-uftc8inx 482 37 populations population NNS cord-010092-uftc8inx 482 38 due due JJ cord-010092-uftc8inx 482 39 to to IN cord-010092-uftc8inx 482 40 immigration immigration NN cord-010092-uftc8inx 482 41 / / SYM cord-010092-uftc8inx 482 42 mobility mobility NN cord-010092-uftc8inx 482 43 and and CC cord-010092-uftc8inx 482 44 for for IN cord-010092-uftc8inx 482 45 less less RBR cord-010092-uftc8inx 482 46 frequently frequently RB cord-010092-uftc8inx 482 47 seen see VBN cord-010092-uftc8inx 482 48 alloantibodies alloantibody NNS cord-010092-uftc8inx 482 49 ( ( -LRB- cord-010092-uftc8inx 482 50 HPA-4 hpa-4 RB cord-010092-uftc8inx 482 51 , , , cord-010092-uftc8inx 482 52 -6 -6 NNP cord-010092-uftc8inx 482 53 to to IN cord-010092-uftc8inx 482 54 -11 -11 ADD cord-010092-uftc8inx 482 55 are be VBP cord-010092-uftc8inx 482 56 most most RBS cord-010092-uftc8inx 482 57 commonly commonly RB cord-010092-uftc8inx 482 58 included include VBN cord-010092-uftc8inx 482 59 ) ) -RRB- cord-010092-uftc8inx 482 60 . . . cord-010092-uftc8inx 483 1 Serological serological JJ cord-010092-uftc8inx 483 2 testing testing NN cord-010092-uftc8inx 483 3 of of IN cord-010092-uftc8inx 483 4 antibody antibody NN cord-010092-uftc8inx 483 5 binding bind VBG cord-010092-uftc8inx 483 6 to to IN cord-010092-uftc8inx 483 7 platelets platelet NNS cord-010092-uftc8inx 483 8 is be VBZ cord-010092-uftc8inx 483 9 often often RB cord-010092-uftc8inx 483 10 initially initially RB cord-010092-uftc8inx 483 11 tested test VBN cord-010092-uftc8inx 483 12 by by IN cord-010092-uftc8inx 483 13 flow flow NN cord-010092-uftc8inx 483 14 cytometry cytometry NN cord-010092-uftc8inx 483 15 analysis analysis NN cord-010092-uftc8inx 483 16 ( ( -LRB- cord-010092-uftc8inx 483 17 direct direct JJ cord-010092-uftc8inx 483 18 test test NN cord-010092-uftc8inx 483 19 and/or and/or CC cord-010092-uftc8inx 483 20 cross cross NN cord-010092-uftc8inx 483 21 - - JJ cord-010092-uftc8inx 483 22 match match NN cord-010092-uftc8inx 483 23 ) ) -RRB- cord-010092-uftc8inx 483 24 . . . cord-010092-uftc8inx 484 1 However however RB cord-010092-uftc8inx 484 2 , , , cord-010092-uftc8inx 484 3 the the DT cord-010092-uftc8inx 484 4 detection detection NN cord-010092-uftc8inx 484 5 of of IN cord-010092-uftc8inx 484 6 platelet platelet NN cord-010092-uftc8inx 484 7 - - HYPH cord-010092-uftc8inx 484 8 specific specific JJ cord-010092-uftc8inx 484 9 antibodies antibody NNS cord-010092-uftc8inx 484 10 is be VBZ cord-010092-uftc8inx 484 11 often often RB cord-010092-uftc8inx 484 12 complicated complicate VBN cord-010092-uftc8inx 484 13 by by IN cord-010092-uftc8inx 484 14 the the DT cord-010092-uftc8inx 484 15 presence presence NN cord-010092-uftc8inx 484 16 of of IN cord-010092-uftc8inx 484 17 anti anti JJ cord-010092-uftc8inx 484 18 - - JJ cord-010092-uftc8inx 484 19 HLA hla JJ cord-010092-uftc8inx 484 20 class class NN cord-010092-uftc8inx 484 21 I -PRON- PRP cord-010092-uftc8inx 484 22 antibodies antibody NNS cord-010092-uftc8inx 484 23 and and CC cord-010092-uftc8inx 484 24 thus thus RB cord-010092-uftc8inx 484 25 require require VB cord-010092-uftc8inx 484 26 sensitive sensitive JJ cord-010092-uftc8inx 484 27 platelet platelet NN cord-010092-uftc8inx 484 28 glycoprotein glycoprotein NN cord-010092-uftc8inx 484 29 - - HYPH cord-010092-uftc8inx 484 30 specific specific JJ cord-010092-uftc8inx 484 31 assays assay NNS cord-010092-uftc8inx 484 32 . . . cord-010092-uftc8inx 485 1 Serological serological JJ cord-010092-uftc8inx 485 2 testing testing NN cord-010092-uftc8inx 485 3 for for IN cord-010092-uftc8inx 485 4 platelet platelet NN cord-010092-uftc8inx 485 5 - - HYPH cord-010092-uftc8inx 485 6 specific specific JJ cord-010092-uftc8inx 485 7 antibodies antibody NNS cord-010092-uftc8inx 485 8 includes include VBZ cord-010092-uftc8inx 485 9 as as IN cord-010092-uftc8inx 485 10 a a DT cord-010092-uftc8inx 485 11 minimum minimum JJ cord-010092-uftc8inx 485 12 panels panel NNS cord-010092-uftc8inx 485 13 of of IN cord-010092-uftc8inx 485 14 antigens antigen NNS cord-010092-uftc8inx 485 15 on on IN cord-010092-uftc8inx 485 16 GPIIb GPIIb NNS cord-010092-uftc8inx 485 17 / / SYM cord-010092-uftc8inx 485 18 IIIa IIIa NNS cord-010092-uftc8inx 485 19 , , , cord-010092-uftc8inx 485 20 GPIb GPIb NNP cord-010092-uftc8inx 485 21 / / SYM cord-010092-uftc8inx 485 22 IX IX NNP cord-010092-uftc8inx 485 23 , , , cord-010092-uftc8inx 485 24 GPIa GPIa NNP cord-010092-uftc8inx 485 25 / / SYM cord-010092-uftc8inx 485 26 IIa IIa NNP cord-010092-uftc8inx 485 27 and and CC cord-010092-uftc8inx 485 28 CD109 CD109 NNP cord-010092-uftc8inx 485 29 and and CC cord-010092-uftc8inx 485 30 preferably preferably RB cord-010092-uftc8inx 485 31 additional additional JJ cord-010092-uftc8inx 485 32 targets target NNS cord-010092-uftc8inx 485 33 for for IN cord-010092-uftc8inx 485 34 populations population NNS cord-010092-uftc8inx 485 35 with with IN cord-010092-uftc8inx 485 36 Asian asian JJ cord-010092-uftc8inx 485 37 / / SYM cord-010092-uftc8inx 485 38 African african JJ cord-010092-uftc8inx 485 39 origin origin NN cord-010092-uftc8inx 485 40 . . . cord-010092-uftc8inx 486 1 Several several JJ cord-010092-uftc8inx 486 2 methods method NNS cord-010092-uftc8inx 486 3 are be VBP cord-010092-uftc8inx 486 4 available available JJ cord-010092-uftc8inx 486 5 ; ; : cord-010092-uftc8inx 486 6 i.e. i.e. FW cord-010092-uftc8inx 486 7 bead bead NN cord-010092-uftc8inx 486 8 - - HYPH cord-010092-uftc8inx 486 9 based base VBN cord-010092-uftc8inx 486 10 assays assay NNS cord-010092-uftc8inx 486 11 and and CC cord-010092-uftc8inx 486 12 ELISA ELISA NNP cord-010092-uftc8inx 486 13 based base VBN cord-010092-uftc8inx 486 14 methods method NNS cord-010092-uftc8inx 486 15 . . . cord-010092-uftc8inx 487 1 However however RB cord-010092-uftc8inx 487 2 , , , cord-010092-uftc8inx 487 3 most most JJS cord-010092-uftc8inx 487 4 reference reference NN cord-010092-uftc8inx 487 5 laboratories laboratory NNS cord-010092-uftc8inx 487 6 perform perform VBP cord-010092-uftc8inx 487 7 variants variant NNS cord-010092-uftc8inx 487 8 of of IN cord-010092-uftc8inx 487 9 the the DT cord-010092-uftc8inx 487 10 monoclonal monoclonal JJ cord-010092-uftc8inx 487 11 antibody antibody NN cord-010092-uftc8inx 487 12 immobilization immobilization NN cord-010092-uftc8inx 487 13 of of IN cord-010092-uftc8inx 487 14 platelet platelet NN cord-010092-uftc8inx 487 15 antigens antigen NNS cord-010092-uftc8inx 487 16 assay assay NN cord-010092-uftc8inx 487 17 ( ( -LRB- cord-010092-uftc8inx 487 18 MAIPA MAIPA NNP cord-010092-uftc8inx 487 19 ) ) -RRB- cord-010092-uftc8inx 487 20 , , , cord-010092-uftc8inx 487 21 as as IN cord-010092-uftc8inx 487 22 reported report VBN cord-010092-uftc8inx 487 23 by by IN cord-010092-uftc8inx 487 24 the the DT cord-010092-uftc8inx 487 25 19th 19th JJ cord-010092-uftc8inx 487 26 International International NNP cord-010092-uftc8inx 487 27 Platelet Platelet NNP cord-010092-uftc8inx 487 28 Immunology Immunology NNP cord-010092-uftc8inx 487 29 Workshop Workshop NNP cord-010092-uftc8inx 487 30 of of IN cord-010092-uftc8inx 487 31 ISBT ISBT NNP cord-010092-uftc8inx 487 32 ( ( -LRB- cord-010092-uftc8inx 487 33 2018 2018 CD cord-010092-uftc8inx 487 34 ) ) -RRB- cord-010092-uftc8inx 487 35 . . . cord-010092-uftc8inx 488 1 The the DT cord-010092-uftc8inx 488 2 investigations investigation NNS cord-010092-uftc8inx 488 3 also also RB cord-010092-uftc8inx 488 4 include include VBP cord-010092-uftc8inx 488 5 measurement measurement NN cord-010092-uftc8inx 488 6 of of IN cord-010092-uftc8inx 488 7 the the DT cord-010092-uftc8inx 488 8 anti anti NNP cord-010092-uftc8inx 488 9 - - NNP cord-010092-uftc8inx 488 10 HPA-1a HPA-1a NNP cord-010092-uftc8inx 488 11 by by IN cord-010092-uftc8inx 488 12 quantitative quantitative JJ cord-010092-uftc8inx 488 13 MAIPA MAIPA NNP cord-010092-uftc8inx 488 14 if if IN cord-010092-uftc8inx 488 15 present present JJ cord-010092-uftc8inx 488 16 , , , cord-010092-uftc8inx 488 17 as as IN cord-010092-uftc8inx 488 18 this this DT cord-010092-uftc8inx 488 19 is be VBZ cord-010092-uftc8inx 488 20 reported report VBN cord-010092-uftc8inx 488 21 to to TO cord-010092-uftc8inx 488 22 potentially potentially RB cord-010092-uftc8inx 488 23 predict predict VB cord-010092-uftc8inx 488 24 the the DT cord-010092-uftc8inx 488 25 severity severity NN cord-010092-uftc8inx 488 26 of of IN cord-010092-uftc8inx 488 27 FNAIT FNAIT NNS cord-010092-uftc8inx 488 28 . . . cord-010092-uftc8inx 489 1 For for IN cord-010092-uftc8inx 489 2 pregnancies pregnancy NNS cord-010092-uftc8inx 489 3 with with IN cord-010092-uftc8inx 489 4 known know VBN cord-010092-uftc8inx 489 5 risk risk NN cord-010092-uftc8inx 489 6 of of IN cord-010092-uftc8inx 489 7 FNAIT FNAIT NNS cord-010092-uftc8inx 489 8 , , , cord-010092-uftc8inx 489 9 there there EX cord-010092-uftc8inx 489 10 are be VBP cord-010092-uftc8inx 489 11 methods method NNS cord-010092-uftc8inx 489 12 available available JJ cord-010092-uftc8inx 489 13 to to TO cord-010092-uftc8inx 489 14 perform perform VB cord-010092-uftc8inx 489 15 non non JJ cord-010092-uftc8inx 489 16 - - JJ cord-010092-uftc8inx 489 17 invasive invasive JJ cord-010092-uftc8inx 489 18 prenatal prenatal JJ cord-010092-uftc8inx 489 19 typing typing NN cord-010092-uftc8inx 489 20 from from IN cord-010092-uftc8inx 489 21 maternal maternal JJ cord-010092-uftc8inx 489 22 plasma plasma NN cord-010092-uftc8inx 489 23 . . . cord-010092-uftc8inx 490 1 The the DT cord-010092-uftc8inx 490 2 most most RBS cord-010092-uftc8inx 490 3 feasible feasible JJ cord-010092-uftc8inx 490 4 and and CC cord-010092-uftc8inx 490 5 so so RB cord-010092-uftc8inx 490 6 far far RB cord-010092-uftc8inx 490 7 appropriate appropriate JJ cord-010092-uftc8inx 490 8 for for IN cord-010092-uftc8inx 490 9 routine routine JJ cord-010092-uftc8inx 490 10 testing testing NN cord-010092-uftc8inx 490 11 is be VBZ cord-010092-uftc8inx 490 12 fetal fetal JJ cord-010092-uftc8inx 490 13 HPA-1 HPA-1 NNP cord-010092-uftc8inx 490 14 typing type VBG cord-010092-uftc8inx 490 15 with with IN cord-010092-uftc8inx 490 16 quantitative quantitative JJ cord-010092-uftc8inx 490 17 PCR PCR NNP cord-010092-uftc8inx 490 18 or or CC cord-010092-uftc8inx 490 19 by by IN cord-010092-uftc8inx 490 20 melting melt VBG cord-010092-uftc8inx 490 21 curve curve NN cord-010092-uftc8inx 490 22 analysis analysis NN cord-010092-uftc8inx 490 23 . . . cord-010092-uftc8inx 491 1 Other other JJ cord-010092-uftc8inx 491 2 sophisticated sophisticated JJ cord-010092-uftc8inx 491 3 , , , cord-010092-uftc8inx 491 4 yet yet CC cord-010092-uftc8inx 491 5 resource resource NN cord-010092-uftc8inx 491 6 - - HYPH cord-010092-uftc8inx 491 7 demanding demand VBG cord-010092-uftc8inx 491 8 techniques technique NNS cord-010092-uftc8inx 491 9 have have VBP cord-010092-uftc8inx 491 10 also also RB cord-010092-uftc8inx 491 11 recently recently RB cord-010092-uftc8inx 491 12 been be VBN cord-010092-uftc8inx 491 13 reported report VBN cord-010092-uftc8inx 491 14 -importantly -importantly RB cord-010092-uftc8inx 491 15 also also RB cord-010092-uftc8inx 491 16 for for IN cord-010092-uftc8inx 491 17 typing typing NN cord-010092-uftc8inx 491 18 of of IN cord-010092-uftc8inx 491 19 other other JJ cord-010092-uftc8inx 491 20 HPA HPA NNP cord-010092-uftc8inx 491 21 - - HYPH cord-010092-uftc8inx 491 22 systems system NNS cord-010092-uftc8inx 491 23 . . . cord-010092-uftc8inx 492 1 2D-08 2d-08 CD cord-010092-uftc8inx 492 2 - - SYM cord-010092-uftc8inx 492 3 03 03 CD cord-010092-uftc8inx 492 4 MOLECULAR molecular NN cord-010092-uftc8inx 492 5 BASIS basis NN cord-010092-uftc8inx 492 6 OF of IN cord-010092-uftc8inx 492 7 HNA-2 hna-2 JJ cord-010092-uftc8inx 492 8 EXPRESSION expression NN cord-010092-uftc8inx 492 9 Justus Justus NNP cord-010092-uftc8inx 492 10 Liebig Liebig NNP cord-010092-uftc8inx 492 11 University University NNP cord-010092-uftc8inx 492 12 , , , cord-010092-uftc8inx 492 13 Institute Institute NNP cord-010092-uftc8inx 492 14 for for IN cord-010092-uftc8inx 492 15 clinical clinical JJ cord-010092-uftc8inx 492 16 immunology immunology NN cord-010092-uftc8inx 492 17 and and CC cord-010092-uftc8inx 492 18 transfusion transfusion NN cord-010092-uftc8inx 492 19 medicine medicine NN cord-010092-uftc8inx 492 20 , , , cord-010092-uftc8inx 492 21 Giessen Giessen NNP cord-010092-uftc8inx 492 22 , , , cord-010092-uftc8inx 492 23 Germany Germany NNP cord-010092-uftc8inx 492 24 Human Human NNP cord-010092-uftc8inx 492 25 neutrophil neutrophil NN cord-010092-uftc8inx 492 26 antigen antigen NNP cord-010092-uftc8inx 492 27 2 2 CD cord-010092-uftc8inx 492 28 ( ( -LRB- cord-010092-uftc8inx 492 29 HNA-2 HNA-2 NNP cord-010092-uftc8inx 492 30 ) ) -RRB- cord-010092-uftc8inx 492 31 is be VBZ cord-010092-uftc8inx 492 32 a a DT cord-010092-uftc8inx 492 33 neutrophil neutrophil NN cord-010092-uftc8inx 492 34 - - HYPH cord-010092-uftc8inx 492 35 specific specific JJ cord-010092-uftc8inx 492 36 antigen antigen NN cord-010092-uftc8inx 492 37 located locate VBN cord-010092-uftc8inx 492 38 on on IN cord-010092-uftc8inx 492 39 GPI GPI NNP cord-010092-uftc8inx 492 40 - - HYPH cord-010092-uftc8inx 492 41 anchored anchor VBN cord-010092-uftc8inx 492 42 glycoprotein glycoprotein NN cord-010092-uftc8inx 492 43 CD177 CD177 NNP cord-010092-uftc8inx 492 44 ( ( -LRB- cord-010092-uftc8inx 492 45 also also RB cord-010092-uftc8inx 492 46 known know VBN cord-010092-uftc8inx 492 47 as as IN cord-010092-uftc8inx 492 48 NB1 NB1 NNP cord-010092-uftc8inx 492 49 ) ) -RRB- cord-010092-uftc8inx 492 50 . . . cord-010092-uftc8inx 493 1 HNA-2 HNA-2 NNP cord-010092-uftc8inx 493 2 is be VBZ cord-010092-uftc8inx 493 3 absent absent JJ cord-010092-uftc8inx 493 4 on on IN cord-010092-uftc8inx 493 5 the the DT cord-010092-uftc8inx 493 6 neutrophil neutrophil NN cord-010092-uftc8inx 493 7 surface surface NN cord-010092-uftc8inx 493 8 of of IN cord-010092-uftc8inx 493 9 3 3 CD cord-010092-uftc8inx 493 10 - - SYM cord-010092-uftc8inx 493 11 5 5 CD cord-010092-uftc8inx 493 12 % % NN cord-010092-uftc8inx 493 13 of of IN cord-010092-uftc8inx 493 14 the the DT cord-010092-uftc8inx 493 15 healthy healthy JJ cord-010092-uftc8inx 493 16 individuals individual NNS cord-010092-uftc8inx 493 17 that that WDT cord-010092-uftc8inx 493 18 divided divide VBD cord-010092-uftc8inx 493 19 the the DT cord-010092-uftc8inx 493 20 population population NN cord-010092-uftc8inx 493 21 to to TO cord-010092-uftc8inx 493 22 HNA-2 hna-2 VB cord-010092-uftc8inx 493 23 positive positive JJ cord-010092-uftc8inx 493 24 and and CC cord-010092-uftc8inx 493 25 HNA-2 hna-2 VB cord-010092-uftc8inx 493 26 null null JJ cord-010092-uftc8inx 493 27 individuals individual NNS cord-010092-uftc8inx 493 28 . . . cord-010092-uftc8inx 494 1 Exposure exposure NN cord-010092-uftc8inx 494 2 of of IN cord-010092-uftc8inx 494 3 HNA-2 hna-2 JJ cord-010092-uftc8inx 494 4 null null JJ cord-010092-uftc8inx 494 5 individuals individual NNS cord-010092-uftc8inx 494 6 to to TO cord-010092-uftc8inx 494 7 HNA-2 hna-2 VB cord-010092-uftc8inx 494 8 positive positive JJ cord-010092-uftc8inx 494 9 neutrophils neutrophil NNS cord-010092-uftc8inx 494 10 during during IN cord-010092-uftc8inx 494 11 pregnancy pregnancy NN cord-010092-uftc8inx 494 12 , , , cord-010092-uftc8inx 494 13 after after IN cord-010092-uftc8inx 494 14 transfusion transfusion NN cord-010092-uftc8inx 494 15 or or CC cord-010092-uftc8inx 494 16 transplantation transplantation NN cord-010092-uftc8inx 494 17 , , , cord-010092-uftc8inx 494 18 induces induce VBZ cord-010092-uftc8inx 494 19 immunization immunization NN cord-010092-uftc8inx 494 20 against against IN cord-010092-uftc8inx 494 21 HNA-2 HNA-2 NNP cord-010092-uftc8inx 494 22 and and CC cord-010092-uftc8inx 494 23 consequently consequently RB cord-010092-uftc8inx 494 24 the the DT cord-010092-uftc8inx 494 25 production production NN cord-010092-uftc8inx 494 26 of of IN cord-010092-uftc8inx 494 27 iso iso NN cord-010092-uftc8inx 494 28 - - HYPH cord-010092-uftc8inx 494 29 antibodies antibody NNS cord-010092-uftc8inx 494 30 . . . cord-010092-uftc8inx 495 1 The the DT cord-010092-uftc8inx 495 2 HNA-2 HNA-2 NNP cord-010092-uftc8inx 495 3 iso iso NN cord-010092-uftc8inx 495 4 - - HYPH cord-010092-uftc8inx 495 5 antibodies antibody NNS cord-010092-uftc8inx 495 6 are be VBP cord-010092-uftc8inx 495 7 involved involve VBN cord-010092-uftc8inx 495 8 in in IN cord-010092-uftc8inx 495 9 the the DT cord-010092-uftc8inx 495 10 mechanism mechanism NN cord-010092-uftc8inx 495 11 of of IN cord-010092-uftc8inx 495 12 neonatal neonatal JJ cord-010092-uftc8inx 495 13 alloimmune alloimmune NNP cord-010092-uftc8inx 495 14 neutropenia neutropenia NN cord-010092-uftc8inx 495 15 ( ( -LRB- cord-010092-uftc8inx 495 16 NAIN NAIN NNP cord-010092-uftc8inx 495 17 ) ) -RRB- cord-010092-uftc8inx 495 18 , , , cord-010092-uftc8inx 495 19 transfusion transfusion NN cord-010092-uftc8inx 495 20 - - HYPH cord-010092-uftc8inx 495 21 related relate VBN cord-010092-uftc8inx 495 22 acute acute JJ cord-010092-uftc8inx 495 23 lung lung NN cord-010092-uftc8inx 495 24 injury injury NN cord-010092-uftc8inx 495 25 ( ( -LRB- cord-010092-uftc8inx 495 26 TRALI TRALI NNP cord-010092-uftc8inx 495 27 ) ) -RRB- cord-010092-uftc8inx 495 28 and and CC cord-010092-uftc8inx 495 29 graft graft NN cord-010092-uftc8inx 495 30 failure failure NN cord-010092-uftc8inx 495 31 following follow VBG cord-010092-uftc8inx 495 32 bone bone NN cord-010092-uftc8inx 495 33 marrow marrow NN cord-010092-uftc8inx 495 34 transplantation transplantation NN cord-010092-uftc8inx 495 35 . . . cord-010092-uftc8inx 496 1 Presence presence NN cord-010092-uftc8inx 496 2 of of IN cord-010092-uftc8inx 496 3 CD177 cd177 NN cord-010092-uftc8inx 496 4 on on IN cord-010092-uftc8inx 496 5 a a DT cord-010092-uftc8inx 496 6 neutrophil neutrophil NN cord-010092-uftc8inx 496 7 surface surface NN cord-010092-uftc8inx 496 8 of of IN cord-010092-uftc8inx 496 9 HNA-2 hna-2 JJ cord-010092-uftc8inx 496 10 positive positive JJ cord-010092-uftc8inx 496 11 individuals individual NNS cord-010092-uftc8inx 496 12 follows follow VBZ cord-010092-uftc8inx 496 13 a a DT cord-010092-uftc8inx 496 14 bimodal bimodal JJ cord-010092-uftc8inx 496 15 expression expression NN cord-010092-uftc8inx 496 16 that that WDT cord-010092-uftc8inx 496 17 categorizes categorize VBZ cord-010092-uftc8inx 496 18 the the DT cord-010092-uftc8inx 496 19 circulating circulate VBG cord-010092-uftc8inx 496 20 neutrophils neutrophil NNS cord-010092-uftc8inx 496 21 to to TO cord-010092-uftc8inx 496 22 HNA-2 hna-2 VB cord-010092-uftc8inx 496 23 positive positive JJ cord-010092-uftc8inx 496 24 and and CC cord-010092-uftc8inx 496 25 negative negative JJ cord-010092-uftc8inx 496 26 subsets subset NNS cord-010092-uftc8inx 496 27 . . . cord-010092-uftc8inx 497 1 The the DT cord-010092-uftc8inx 497 2 CD177 CD177 NNP cord-010092-uftc8inx 497 3 gene gene NN cord-010092-uftc8inx 497 4 contains contain VBZ cord-010092-uftc8inx 497 5 9 9 CD cord-010092-uftc8inx 497 6 exons exon NNS cord-010092-uftc8inx 497 7 encoding encode VBG cord-010092-uftc8inx 497 8 a a DT cord-010092-uftc8inx 497 9 protein protein NN cord-010092-uftc8inx 497 10 of of IN cord-010092-uftc8inx 497 11 437 437 CD cord-010092-uftc8inx 497 12 amino amino JJ cord-010092-uftc8inx 497 13 acids acid NNS cord-010092-uftc8inx 497 14 . . . cord-010092-uftc8inx 498 1 The the DT cord-010092-uftc8inx 498 2 lack lack NN cord-010092-uftc8inx 498 3 of of IN cord-010092-uftc8inx 498 4 HNA-2 HNA-2 NNP cord-010092-uftc8inx 498 5 ( ( -LRB- cord-010092-uftc8inx 498 6 in in IN cord-010092-uftc8inx 498 7 HNA-2 HNA-2 NNP cord-010092-uftc8inx 498 8 null null JJ cord-010092-uftc8inx 498 9 individuals individual NNS cord-010092-uftc8inx 498 10 ) ) -RRB- cord-010092-uftc8inx 498 11 is be VBZ cord-010092-uftc8inx 498 12 associated associate VBN cord-010092-uftc8inx 498 13 with with IN cord-010092-uftc8inx 498 14 the the DT cord-010092-uftc8inx 498 15 presence presence NN cord-010092-uftc8inx 498 16 of of IN cord-010092-uftc8inx 498 17 a a DT cord-010092-uftc8inx 498 18 missense missense JJ cord-010092-uftc8inx 498 19 mutation mutation NN cord-010092-uftc8inx 498 20 , , , cord-010092-uftc8inx 499 1 CD177*c.787A cd177*c.787a XX cord-010092-uftc8inx 499 2 > > XX cord-010092-uftc8inx 499 3 T T NNP cord-010092-uftc8inx 499 4 in in IN cord-010092-uftc8inx 499 5 exon exon NN cord-010092-uftc8inx 499 6 7 7 CD cord-010092-uftc8inx 499 7 of of IN cord-010092-uftc8inx 499 8 CD177 CD177 NNP cord-010092-uftc8inx 499 9 gene gene NN cord-010092-uftc8inx 499 10 inducing induce VBG cord-010092-uftc8inx 499 11 a a DT cord-010092-uftc8inx 499 12 premature premature JJ cord-010092-uftc8inx 499 13 stop stop NN cord-010092-uftc8inx 499 14 codon codon NN cord-010092-uftc8inx 499 15 in in IN cord-010092-uftc8inx 499 16 codon codon NN cord-010092-uftc8inx 499 17 263 263 CD cord-010092-uftc8inx 499 18 . . . cord-010092-uftc8inx 500 1 This this DT cord-010092-uftc8inx 500 2 mutation mutation NN cord-010092-uftc8inx 500 3 alone alone RB cord-010092-uftc8inx 500 4 or or CC cord-010092-uftc8inx 500 5 in in IN cord-010092-uftc8inx 500 6 combination combination NN cord-010092-uftc8inx 500 7 with with IN cord-010092-uftc8inx 500 8 CD177*c.997delG CD177*c.997delG NNP cord-010092-uftc8inx 500 9 has have VBZ cord-010092-uftc8inx 500 10 been be VBN cord-010092-uftc8inx 500 11 introduced introduce VBN cord-010092-uftc8inx 500 12 as as IN cord-010092-uftc8inx 500 13 the the DT cord-010092-uftc8inx 500 14 main main JJ cord-010092-uftc8inx 500 15 reason reason NN cord-010092-uftc8inx 500 16 for for IN cord-010092-uftc8inx 500 17 the the DT cord-010092-uftc8inx 500 18 absence absence NN cord-010092-uftc8inx 500 19 of of IN cord-010092-uftc8inx 500 20 CD177 cd177 NN cord-010092-uftc8inx 500 21 in in IN cord-010092-uftc8inx 500 22 HNA-2 HNA-2 NNP cord-010092-uftc8inx 500 23 null null JJ cord-010092-uftc8inx 500 24 individuals individual NNS cord-010092-uftc8inx 500 25 . . . cord-010092-uftc8inx 501 1 A a DT cord-010092-uftc8inx 501 2 pseudogene pseudogene NN cord-010092-uftc8inx 501 3 ( ( -LRB- cord-010092-uftc8inx 501 4 CD177P1 CD177P1 NNP cord-010092-uftc8inx 501 5 ) ) -RRB- cord-010092-uftc8inx 501 6 highly highly RB cord-010092-uftc8inx 501 7 homologous homologous JJ cord-010092-uftc8inx 501 8 to to IN cord-010092-uftc8inx 501 9 exons exon NNS cord-010092-uftc8inx 501 10 4 4 CD cord-010092-uftc8inx 501 11 - - SYM cord-010092-uftc8inx 501 12 9 9 CD cord-010092-uftc8inx 501 13 of of IN cord-010092-uftc8inx 501 14 CD177 cd177 NN cord-010092-uftc8inx 501 15 gene gene NN cord-010092-uftc8inx 501 16 is be VBZ cord-010092-uftc8inx 501 17 located locate VBN cord-010092-uftc8inx 501 18 downstream downstream RB cord-010092-uftc8inx 501 19 of of IN cord-010092-uftc8inx 501 20 the the DT cord-010092-uftc8inx 501 21 CD177 CD177 NNP cord-010092-uftc8inx 501 22 gene gene NN cord-010092-uftc8inx 501 23 . . . cord-010092-uftc8inx 502 1 Conversion conversion NN cord-010092-uftc8inx 502 2 of of IN cord-010092-uftc8inx 502 3 exon exon NN cord-010092-uftc8inx 502 4 7 7 CD cord-010092-uftc8inx 502 5 of of IN cord-010092-uftc8inx 502 6 CD177P1 CD177P1 NNP cord-010092-uftc8inx 502 7 into into IN cord-010092-uftc8inx 502 8 CD177 cd177 NN cord-010092-uftc8inx 502 9 gene gene NN cord-010092-uftc8inx 502 10 is be VBZ cord-010092-uftc8inx 502 11 responsible responsible JJ cord-010092-uftc8inx 502 12 for for IN cord-010092-uftc8inx 502 13 the the DT cord-010092-uftc8inx 502 14 generation generation NN cord-010092-uftc8inx 502 15 of of IN cord-010092-uftc8inx 502 16 CD177*c.787A cd177*c.787a NN cord-010092-uftc8inx 502 17 > > XX cord-010092-uftc8inx 502 18 T t NN cord-010092-uftc8inx 502 19 missense missense NN cord-010092-uftc8inx 502 20 mutation mutation NN cord-010092-uftc8inx 502 21 . . . cord-010092-uftc8inx 503 1 In in IN cord-010092-uftc8inx 503 2 addition addition NN cord-010092-uftc8inx 503 3 , , , cord-010092-uftc8inx 503 4 the the DT cord-010092-uftc8inx 503 5 heterozygosity heterozygosity NN cord-010092-uftc8inx 503 6 or or CC cord-010092-uftc8inx 503 7 homozygosity homozygosity NN cord-010092-uftc8inx 503 8 of of IN cord-010092-uftc8inx 503 9 CD177*c.787A cd177*c.787a NN cord-010092-uftc8inx 503 10 > > XX cord-010092-uftc8inx 504 1 T T NNP cord-010092-uftc8inx 504 2 is be VBZ cord-010092-uftc8inx 504 3 accounted account VBN cord-010092-uftc8inx 504 4 for for IN cord-010092-uftc8inx 504 5 regulation regulation NN cord-010092-uftc8inx 504 6 of of IN cord-010092-uftc8inx 504 7 HNA-2 HNA-2 NNP cord-010092-uftc8inx 504 8 negative negative JJ cord-010092-uftc8inx 504 9 and and CC cord-010092-uftc8inx 504 10 positive positive JJ cord-010092-uftc8inx 504 11 neutrophils neutrophil NNS cord-010092-uftc8inx 504 12 subpopulations subpopulation NNS cord-010092-uftc8inx 504 13 . . . cord-010092-uftc8inx 505 1 Genotyping Genotyping NNP cord-010092-uftc8inx 505 2 has have VBZ cord-010092-uftc8inx 505 3 revealed reveal VBN cord-010092-uftc8inx 505 4 the the DT cord-010092-uftc8inx 505 5 HNA-2 HNA-2 NNP cord-010092-uftc8inx 505 6 null null JJ cord-010092-uftc8inx 505 7 individuals individual NNS cord-010092-uftc8inx 505 8 , , , cord-010092-uftc8inx 505 9 heterozygous heterozygous JJ cord-010092-uftc8inx 505 10 for for IN cord-010092-uftc8inx 505 11 CD177*c.787A cd177*c.787a NN cord-010092-uftc8inx 505 12 > > XX cord-010092-uftc8inx 505 13 T t NN cord-010092-uftc8inx 505 14 mutation mutation NN cord-010092-uftc8inx 505 15 without without IN cord-010092-uftc8inx 505 16 CD177*c.997delG CD177*c.997delG NNP cord-010092-uftc8inx 505 17 , , , cord-010092-uftc8inx 505 18 indicating indicate VBG cord-010092-uftc8inx 505 19 the the DT cord-010092-uftc8inx 505 20 presence presence NN cord-010092-uftc8inx 505 21 of of IN cord-010092-uftc8inx 505 22 a a DT cord-010092-uftc8inx 505 23 complementary complementary JJ cord-010092-uftc8inx 505 24 mechanism mechanism NN cord-010092-uftc8inx 505 25 regulating regulate VBG cord-010092-uftc8inx 505 26 CD177 cd177 DT cord-010092-uftc8inx 505 27 expression expression NN cord-010092-uftc8inx 505 28 . . . cord-010092-uftc8inx 506 1 Newly newly RB cord-010092-uftc8inx 506 2 in in IN cord-010092-uftc8inx 506 3 HNA-2 HNA-2 NNP cord-010092-uftc8inx 506 4 null null JJ cord-010092-uftc8inx 506 5 individuals individual NNS cord-010092-uftc8inx 506 6 and and CC cord-010092-uftc8inx 506 7 individuals individual NNS cord-010092-uftc8inx 506 8 with with IN cord-010092-uftc8inx 506 9 atypical atypical JJ cord-010092-uftc8inx 506 10 CD177 CD177 NNP cord-010092-uftc8inx 506 11 expression expression NN cord-010092-uftc8inx 507 1 a a DT cord-010092-uftc8inx 507 2 CD177 cd177 NN cord-010092-uftc8inx 508 1 * * NFP cord-010092-uftc8inx 508 2 1291 1291 CD cord-010092-uftc8inx 508 3 G g NN cord-010092-uftc8inx 509 1 > > XX cord-010092-uftc8inx 510 1 A a DT cord-010092-uftc8inx 510 2 polymorphism polymorphism NN cord-010092-uftc8inx 510 3 in in IN cord-010092-uftc8inx 510 4 combination combination NN cord-010092-uftc8inx 510 5 with with IN cord-010092-uftc8inx 510 6 CD177 cd177 NN cord-010092-uftc8inx 511 1 * * NFP cord-010092-uftc8inx 511 2 787A 787a CD cord-010092-uftc8inx 512 1 > > XX cord-010092-uftc8inx 513 1 T T NNP cord-010092-uftc8inx 513 2 is be VBZ cord-010092-uftc8inx 513 3 described describe VBN cord-010092-uftc8inx 513 4 . . . cord-010092-uftc8inx 514 1 Altogether altogether RB cord-010092-uftc8inx 514 2 these these DT cord-010092-uftc8inx 514 3 data datum NNS cord-010092-uftc8inx 514 4 indicate indicate VBP cord-010092-uftc8inx 514 5 a a DT cord-010092-uftc8inx 514 6 complex complex JJ cord-010092-uftc8inx 514 7 compound compound NN cord-010092-uftc8inx 514 8 mechanism(s mechanism(s NNP cord-010092-uftc8inx 514 9 ) ) -RRB- cord-010092-uftc8inx 514 10 for for IN cord-010092-uftc8inx 514 11 regulation regulation NN cord-010092-uftc8inx 514 12 of of IN cord-010092-uftc8inx 514 13 CD177 cd177 NN cord-010092-uftc8inx 514 14 expression expression NN cord-010092-uftc8inx 514 15 on on IN cord-010092-uftc8inx 514 16 the the DT cord-010092-uftc8inx 514 17 neutrophil neutrophil NN cord-010092-uftc8inx 514 18 surface surface NN cord-010092-uftc8inx 514 19 . . . cord-010092-uftc8inx 515 1 This this DT cord-010092-uftc8inx 515 2 presentation presentation NN cord-010092-uftc8inx 515 3 will will MD cord-010092-uftc8inx 515 4 summarize summarize VB cord-010092-uftc8inx 515 5 recent recent JJ cord-010092-uftc8inx 515 6 findings finding NNS cord-010092-uftc8inx 515 7 on on IN cord-010092-uftc8inx 515 8 CD177 cd177 DT cord-010092-uftc8inx 515 9 expression expression NN cord-010092-uftc8inx 515 10 and and CC cord-010092-uftc8inx 515 11 highlights highlight VBZ cord-010092-uftc8inx 515 12 the the DT cord-010092-uftc8inx 515 13 potential potential JJ cord-010092-uftc8inx 515 14 genotyping genotyping NN cord-010092-uftc8inx 515 15 methods method NNS cord-010092-uftc8inx 515 16 for for IN cord-010092-uftc8inx 515 17 genetic genetic JJ cord-010092-uftc8inx 515 18 assessment assessment NN cord-010092-uftc8inx 515 19 CD177 cd177 NN cord-010092-uftc8inx 515 20 expression expression NN cord-010092-uftc8inx 515 21 of of IN cord-010092-uftc8inx 515 22 donors donor NNS cord-010092-uftc8inx 515 23 and and CC cord-010092-uftc8inx 515 24 patients patient NNS cord-010092-uftc8inx 515 25 . . . cord-010092-uftc8inx 516 1 blood blood NN cord-010092-uftc8inx 516 2 products product NNS cord-010092-uftc8inx 516 3 ordered order VBN cord-010092-uftc8inx 516 4 , , , cord-010092-uftc8inx 516 5 transfusion transfusion NN cord-010092-uftc8inx 516 6 start start NN cord-010092-uftc8inx 516 7 and and CC cord-010092-uftc8inx 516 8 end end VB cord-010092-uftc8inx 516 9 times time NNS cord-010092-uftc8inx 516 10 , , , cord-010092-uftc8inx 516 11 whether whether IN cord-010092-uftc8inx 516 12 patients patient NNS cord-010092-uftc8inx 516 13 experienced experience VBD cord-010092-uftc8inx 516 14 a a DT cord-010092-uftc8inx 516 15 reaction reaction NN cord-010092-uftc8inx 516 16 to to IN cord-010092-uftc8inx 516 17 the the DT cord-010092-uftc8inx 516 18 transfusion transfusion NN cord-010092-uftc8inx 516 19 as as RB cord-010092-uftc8inx 516 20 well well RB cord-010092-uftc8inx 516 21 as as IN cord-010092-uftc8inx 516 22 vitals vitals NN cord-010092-uftc8inx 516 23 measurements measurement NNS cord-010092-uftc8inx 516 24 taken take VBN cord-010092-uftc8inx 516 25 before before RB cord-010092-uftc8inx 516 26 and and CC cord-010092-uftc8inx 516 27 during during IN cord-010092-uftc8inx 516 28 the the DT cord-010092-uftc8inx 516 29 transfusion transfusion NN cord-010092-uftc8inx 516 30 , , , cord-010092-uftc8inx 516 31 including include VBG cord-010092-uftc8inx 516 32 temperature temperature NN cord-010092-uftc8inx 516 33 , , , cord-010092-uftc8inx 516 34 oxygen oxygen NN cord-010092-uftc8inx 516 35 level level NN cord-010092-uftc8inx 516 36 , , , cord-010092-uftc8inx 516 37 blood blood NN cord-010092-uftc8inx 516 38 pressure pressure NN cord-010092-uftc8inx 516 39 and and CC cord-010092-uftc8inx 516 40 heart heart NN cord-010092-uftc8inx 516 41 rate rate NN cord-010092-uftc8inx 516 42 . . . cord-010092-uftc8inx 517 1 For for IN cord-010092-uftc8inx 517 2 the the DT cord-010092-uftc8inx 517 3 validation validation NN cord-010092-uftc8inx 517 4 process process NN cord-010092-uftc8inx 517 5 , , , cord-010092-uftc8inx 517 6 100 100 CD cord-010092-uftc8inx 517 7 transfusion transfusion NN cord-010092-uftc8inx 517 8 nursing nursing NN cord-010092-uftc8inx 517 9 notes note NNS cord-010092-uftc8inx 517 10 were be VBD cord-010092-uftc8inx 517 11 sampled sample VBN cord-010092-uftc8inx 517 12 and and CC cord-010092-uftc8inx 517 13 reviewers reviewer NNS cord-010092-uftc8inx 517 14 assessed assess VBD cord-010092-uftc8inx 517 15 the the DT cord-010092-uftc8inx 517 16 accuracy accuracy NN cord-010092-uftc8inx 517 17 of of IN cord-010092-uftc8inx 517 18 the the DT cord-010092-uftc8inx 517 19 information information NN cord-010092-uftc8inx 517 20 regarding regard VBG cord-010092-uftc8inx 517 21 1 1 CD cord-010092-uftc8inx 517 22 ) ) -RRB- cord-010092-uftc8inx 517 23 blood blood NN cord-010092-uftc8inx 517 24 product product NN cord-010092-uftc8inx 517 25 ordered order VBN cord-010092-uftc8inx 517 26 , , , cord-010092-uftc8inx 517 27 2 2 CD cord-010092-uftc8inx 517 28 ) ) -RRB- cord-010092-uftc8inx 517 29 whether whether IN cord-010092-uftc8inx 517 30 the the DT cord-010092-uftc8inx 517 31 patient patient NN cord-010092-uftc8inx 517 32 experienced experience VBD cord-010092-uftc8inx 517 33 a a DT cord-010092-uftc8inx 517 34 reaction reaction NN cord-010092-uftc8inx 517 35 , , , cord-010092-uftc8inx 517 36 and and CC cord-010092-uftc8inx 517 37 3 3 LS cord-010092-uftc8inx 517 38 ) ) -RRB- cord-010092-uftc8inx 517 39 the the DT cord-010092-uftc8inx 517 40 start start NN cord-010092-uftc8inx 517 41 and and CC cord-010092-uftc8inx 517 42 end end VB cord-010092-uftc8inx 517 43 times time NNS cord-010092-uftc8inx 517 44 of of IN cord-010092-uftc8inx 517 45 the the DT cord-010092-uftc8inx 517 46 transfusion transfusion NN cord-010092-uftc8inx 517 47 . . . cord-010092-uftc8inx 518 1 For for IN cord-010092-uftc8inx 518 2 each each DT cord-010092-uftc8inx 518 3 of of IN cord-010092-uftc8inx 518 4 these these DT cord-010092-uftc8inx 518 5 fields field NNS cord-010092-uftc8inx 518 6 across across IN cord-010092-uftc8inx 518 7 all all DT cord-010092-uftc8inx 518 8 100 100 CD cord-010092-uftc8inx 518 9 sampled sample VBN cord-010092-uftc8inx 518 10 notes note NNS cord-010092-uftc8inx 518 11 , , , cord-010092-uftc8inx 518 12 the the DT cord-010092-uftc8inx 518 13 ClarityNLP ClarityNLP NNP cord-010092-uftc8inx 518 14 tool tool NN cord-010092-uftc8inx 518 15 reproduced reproduce VBD cord-010092-uftc8inx 518 16 these these DT cord-010092-uftc8inx 518 17 data datum NNS cord-010092-uftc8inx 518 18 points point NNS cord-010092-uftc8inx 518 19 with with IN cord-010092-uftc8inx 518 20 100 100 CD cord-010092-uftc8inx 518 21 percent percent NN cord-010092-uftc8inx 518 22 accuracy accuracy NN cord-010092-uftc8inx 518 23 . . . cord-010092-uftc8inx 519 1 In in IN cord-010092-uftc8inx 519 2 addition addition NN cord-010092-uftc8inx 519 3 , , , cord-010092-uftc8inx 519 4 the the DT cord-010092-uftc8inx 519 5 tool tool NN cord-010092-uftc8inx 519 6 supplied supply VBD cord-010092-uftc8inx 519 7 transfusion transfusion NN cord-010092-uftc8inx 519 8 end end NN cord-010092-uftc8inx 519 9 times time NNS cord-010092-uftc8inx 519 10 for for IN cord-010092-uftc8inx 519 11 numerous numerous JJ cord-010092-uftc8inx 519 12 structured structured JJ cord-010092-uftc8inx 519 13 records record NNS cord-010092-uftc8inx 519 14 that that WDT cord-010092-uftc8inx 519 15 were be VBD cord-010092-uftc8inx 519 16 missing miss VBG cord-010092-uftc8inx 519 17 this this DT cord-010092-uftc8inx 519 18 key key JJ cord-010092-uftc8inx 519 19 data data NN cord-010092-uftc8inx 519 20 point point NN cord-010092-uftc8inx 519 21 . . . cord-010092-uftc8inx 520 1 Summary Summary NNP cord-010092-uftc8inx 520 2 / / SYM cord-010092-uftc8inx 520 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 520 4 : : : cord-010092-uftc8inx 520 5 ClarityNLP ClarityNLP NNP cord-010092-uftc8inx 520 6 can can MD cord-010092-uftc8inx 520 7 very very RB cord-010092-uftc8inx 520 8 efficiently efficiently RB cord-010092-uftc8inx 520 9 digest digest VB cord-010092-uftc8inx 520 10 a a DT cord-010092-uftc8inx 520 11 large large JJ cord-010092-uftc8inx 520 12 number number NN cord-010092-uftc8inx 520 13 of of IN cord-010092-uftc8inx 520 14 transfusion transfusion NN cord-010092-uftc8inx 520 15 nursing nursing NN cord-010092-uftc8inx 520 16 notes note NNS cord-010092-uftc8inx 520 17 simultaneously simultaneously RB cord-010092-uftc8inx 520 18 and and CC cord-010092-uftc8inx 520 19 also also RB cord-010092-uftc8inx 520 20 does do VBZ cord-010092-uftc8inx 520 21 an an DT cord-010092-uftc8inx 520 22 excellent excellent JJ cord-010092-uftc8inx 520 23 job job NN cord-010092-uftc8inx 520 24 of of IN cord-010092-uftc8inx 520 25 extracting extract VBG cord-010092-uftc8inx 520 26 the the DT cord-010092-uftc8inx 520 27 main main JJ cord-010092-uftc8inx 520 28 characteristics characteristic NNS cord-010092-uftc8inx 520 29 of of IN cord-010092-uftc8inx 520 30 a a DT cord-010092-uftc8inx 520 31 transfusion transfusion NN cord-010092-uftc8inx 520 32 , , , cord-010092-uftc8inx 520 33 which which WDT cord-010092-uftc8inx 520 34 can can MD cord-010092-uftc8inx 520 35 be be VB cord-010092-uftc8inx 520 36 used use VBN cord-010092-uftc8inx 520 37 in in IN cord-010092-uftc8inx 520 38 partnership partnership NN cord-010092-uftc8inx 520 39 with with IN cord-010092-uftc8inx 520 40 structured structured JJ cord-010092-uftc8inx 520 41 data datum NNS cord-010092-uftc8inx 520 42 to to TO cord-010092-uftc8inx 520 43 produce produce VB cord-010092-uftc8inx 520 44 a a DT cord-010092-uftc8inx 520 45 more more RBR cord-010092-uftc8inx 520 46 accurate accurate JJ cord-010092-uftc8inx 520 47 and and CC cord-010092-uftc8inx 520 48 more more RBR cord-010092-uftc8inx 520 49 complete complete JJ cord-010092-uftc8inx 520 50 picture picture NN cord-010092-uftc8inx 520 51 of of IN cord-010092-uftc8inx 520 52 patient patient JJ cord-010092-uftc8inx 520 53 transfusions transfusion NNS cord-010092-uftc8inx 520 54 . . . cord-010092-uftc8inx 521 1 Immunohematology Immunohematology NNP cord-010092-uftc8inx 521 2 and and CC cord-010092-uftc8inx 521 3 Genomics Genomics NNP cord-010092-uftc8inx 521 4 , , , cord-010092-uftc8inx 521 5 New New NNP cord-010092-uftc8inx 521 6 York York NNP cord-010092-uftc8inx 521 7 Blood Blood NNP cord-010092-uftc8inx 521 8 Center Center NNP cord-010092-uftc8inx 521 9 , , , cord-010092-uftc8inx 521 10 New New NNP cord-010092-uftc8inx 521 11 York York NNP cord-010092-uftc8inx 521 12 , , , cord-010092-uftc8inx 521 13 United United NNP cord-010092-uftc8inx 521 14 States States NNP cord-010092-uftc8inx 521 15 Antibody Antibody NNP cord-010092-uftc8inx 521 16 - - HYPH cord-010092-uftc8inx 521 17 based base VBN cord-010092-uftc8inx 521 18 typing typing NN cord-010092-uftc8inx 521 19 , , , cord-010092-uftc8inx 521 20 with with IN cord-010092-uftc8inx 521 21 a a DT cord-010092-uftc8inx 521 22 positive positive JJ cord-010092-uftc8inx 521 23 result result NN cord-010092-uftc8inx 521 24 reflected reflect VBN cord-010092-uftc8inx 521 25 in in IN cord-010092-uftc8inx 521 26 agglutination agglutination NN cord-010092-uftc8inx 521 27 of of IN cord-010092-uftc8inx 521 28 the the DT cord-010092-uftc8inx 521 29 red red JJ cord-010092-uftc8inx 521 30 cells cell NNS cord-010092-uftc8inx 521 31 ( ( -LRB- cord-010092-uftc8inx 521 32 RBCs rbc NNS cord-010092-uftc8inx 521 33 ) ) -RRB- cord-010092-uftc8inx 521 34 , , , cord-010092-uftc8inx 521 35 has have VBZ cord-010092-uftc8inx 521 36 served serve VBN cord-010092-uftc8inx 521 37 the the DT cord-010092-uftc8inx 521 38 profession profession NN cord-010092-uftc8inx 521 39 for for IN cord-010092-uftc8inx 521 40 nearly nearly RB cord-010092-uftc8inx 521 41 a a DT cord-010092-uftc8inx 521 42 century century NN cord-010092-uftc8inx 521 43 enabling enable VBG cord-010092-uftc8inx 521 44 safe safe JJ cord-010092-uftc8inx 521 45 and and CC cord-010092-uftc8inx 521 46 effective effective JJ cord-010092-uftc8inx 521 47 transfusion transfusion NN cord-010092-uftc8inx 521 48 therapy therapy NN cord-010092-uftc8inx 521 49 . . . cord-010092-uftc8inx 522 1 The the DT cord-010092-uftc8inx 522 2 power power NN cord-010092-uftc8inx 522 3 of of IN cord-010092-uftc8inx 522 4 RBC RBC NNP cord-010092-uftc8inx 522 5 typing typing NN cord-010092-uftc8inx 522 6 by by IN cord-010092-uftc8inx 522 7 serologic serologic JJ cord-010092-uftc8inx 522 8 methods method NNS cord-010092-uftc8inx 522 9 lies lie VBZ cord-010092-uftc8inx 522 10 in in IN cord-010092-uftc8inx 522 11 the the DT cord-010092-uftc8inx 522 12 availability availability NN cord-010092-uftc8inx 522 13 of of IN cord-010092-uftc8inx 522 14 standardized standardized JJ cord-010092-uftc8inx 522 15 antibody antibody NN cord-010092-uftc8inx 522 16 reagents reagent NNS cord-010092-uftc8inx 522 17 which which WDT cord-010092-uftc8inx 522 18 target target VBP cord-010092-uftc8inx 522 19 many many JJ cord-010092-uftc8inx 522 20 of of IN cord-010092-uftc8inx 522 21 the the DT cord-010092-uftc8inx 522 22 specificities specificity NNS cord-010092-uftc8inx 522 23 of of IN cord-010092-uftc8inx 522 24 significance significance NN cord-010092-uftc8inx 522 25 for for IN cord-010092-uftc8inx 522 26 transfusion transfusion NN cord-010092-uftc8inx 522 27 , , , cord-010092-uftc8inx 522 28 and and CC cord-010092-uftc8inx 522 29 the the DT cord-010092-uftc8inx 522 30 ability ability NN cord-010092-uftc8inx 522 31 to to TO cord-010092-uftc8inx 522 32 directly directly RB cord-010092-uftc8inx 522 33 detect detect VB cord-010092-uftc8inx 522 34 antigen antigen NN cord-010092-uftc8inx 522 35 expression expression NN cord-010092-uftc8inx 522 36 on on IN cord-010092-uftc8inx 522 37 the the DT cord-010092-uftc8inx 522 38 RBCs rbc NNS cord-010092-uftc8inx 522 39 . . . cord-010092-uftc8inx 523 1 Hemagglutination Hemagglutination NNP cord-010092-uftc8inx 523 2 has have VBZ cord-010092-uftc8inx 523 3 historically historically RB cord-010092-uftc8inx 523 4 been be VBN cord-010092-uftc8inx 523 5 relatively relatively RB cord-010092-uftc8inx 523 6 inexpensive inexpensive JJ cord-010092-uftc8inx 523 7 , , , cord-010092-uftc8inx 523 8 particularly particularly RB cord-010092-uftc8inx 523 9 for for IN cord-010092-uftc8inx 523 10 ABO ABO NNP cord-010092-uftc8inx 523 11 and and CC cord-010092-uftc8inx 523 12 RhD rhd NN cord-010092-uftc8inx 523 13 as as IN cord-010092-uftc8inx 523 14 the the DT cord-010092-uftc8inx 523 15 most most RBS cord-010092-uftc8inx 523 16 important important JJ cord-010092-uftc8inx 523 17 blood blood NN cord-010092-uftc8inx 523 18 groups group NNS cord-010092-uftc8inx 523 19 in in IN cord-010092-uftc8inx 523 20 most most JJS cord-010092-uftc8inx 523 21 populations population NNS cord-010092-uftc8inx 523 22 . . . cord-010092-uftc8inx 524 1 Serologic Serologic NNP cord-010092-uftc8inx 524 2 RBC RBC NNP cord-010092-uftc8inx 524 3 typing typing NN cord-010092-uftc8inx 524 4 is be VBZ cord-010092-uftc8inx 524 5 reliable reliable JJ cord-010092-uftc8inx 524 6 , , , cord-010092-uftc8inx 524 7 requires require VBZ cord-010092-uftc8inx 524 8 no no DT cord-010092-uftc8inx 524 9 sophisticated sophisticated JJ cord-010092-uftc8inx 524 10 equipment equipment NN cord-010092-uftc8inx 524 11 , , , cord-010092-uftc8inx 524 12 is be VBZ cord-010092-uftc8inx 524 13 generally generally RB cord-010092-uftc8inx 524 14 straightforward straightforward JJ cord-010092-uftc8inx 524 15 to to TO cord-010092-uftc8inx 524 16 perform perform VB cord-010092-uftc8inx 524 17 , , , cord-010092-uftc8inx 524 18 and and CC cord-010092-uftc8inx 524 19 is be VBZ cord-010092-uftc8inx 524 20 fast fast RB cord-010092-uftc8inx 524 21 requiring require VBG cord-010092-uftc8inx 524 22 less less JJR cord-010092-uftc8inx 524 23 than than IN cord-010092-uftc8inx 524 24 1 1 CD cord-010092-uftc8inx 524 25 h h NN cord-010092-uftc8inx 524 26 to to IN cord-010092-uftc8inx 524 27 results result NNS cord-010092-uftc8inx 524 28 . . . cord-010092-uftc8inx 525 1 Hence hence RB cord-010092-uftc8inx 525 2 , , , cord-010092-uftc8inx 525 3 antibody antibody NN cord-010092-uftc8inx 525 4 - - HYPH cord-010092-uftc8inx 525 5 based base VBN cord-010092-uftc8inx 525 6 testing testing NN cord-010092-uftc8inx 525 7 has have VBZ cord-010092-uftc8inx 525 8 been be VBN cord-010092-uftc8inx 525 9 considered consider VBN cord-010092-uftc8inx 525 10 the the DT cord-010092-uftc8inx 525 11 " " `` cord-010092-uftc8inx 525 12 gold gold NN cord-010092-uftc8inx 525 13 standard standard NN cord-010092-uftc8inx 525 14 " " '' cord-010092-uftc8inx 525 15 for for IN cord-010092-uftc8inx 525 16 blood blood NN cord-010092-uftc8inx 525 17 group group NN cord-010092-uftc8inx 525 18 typing typing NN cord-010092-uftc8inx 525 19 . . . cord-010092-uftc8inx 526 1 With with IN cord-010092-uftc8inx 526 2 the the DT cord-010092-uftc8inx 526 3 age age NN cord-010092-uftc8inx 526 4 of of IN cord-010092-uftc8inx 526 5 genomics genomic NNS cord-010092-uftc8inx 526 6 , , , cord-010092-uftc8inx 526 7 DNA dna NN cord-010092-uftc8inx 526 8 - - HYPH cord-010092-uftc8inx 526 9 based base VBN cord-010092-uftc8inx 526 10 genotyping genotyping NN cord-010092-uftc8inx 526 11 is be VBZ cord-010092-uftc8inx 526 12 increasingly increasingly RB cord-010092-uftc8inx 526 13 being be VBG cord-010092-uftc8inx 526 14 used use VBN cord-010092-uftc8inx 526 15 as as IN cord-010092-uftc8inx 526 16 an an DT cord-010092-uftc8inx 526 17 alternative alternative NN cord-010092-uftc8inx 526 18 to to IN cord-010092-uftc8inx 526 19 antibody antibody NN cord-010092-uftc8inx 526 20 - - HYPH cord-010092-uftc8inx 526 21 based base VBN cord-010092-uftc8inx 526 22 methods method NNS cord-010092-uftc8inx 526 23 . . . cord-010092-uftc8inx 527 1 Most Most JJS cord-010092-uftc8inx 527 2 antigens antigen NNS cord-010092-uftc8inx 527 3 are be VBP cord-010092-uftc8inx 527 4 associated associate VBN cord-010092-uftc8inx 527 5 with with IN cord-010092-uftc8inx 527 6 single single JJ cord-010092-uftc8inx 527 7 nucleotide nucleotide JJ cord-010092-uftc8inx 527 8 changes change NNS cord-010092-uftc8inx 527 9 ( ( -LRB- cord-010092-uftc8inx 527 10 SNPs SNPs NNP cord-010092-uftc8inx 527 11 ) ) -RRB- cord-010092-uftc8inx 527 12 in in IN cord-010092-uftc8inx 527 13 the the DT cord-010092-uftc8inx 527 14 respective respective JJ cord-010092-uftc8inx 527 15 genes gene NNS cord-010092-uftc8inx 527 16 . . . cord-010092-uftc8inx 528 1 Genotyping Genotyping NNP cord-010092-uftc8inx 528 2 has have VBZ cord-010092-uftc8inx 528 3 been be VBN cord-010092-uftc8inx 528 4 validated validate VBN cord-010092-uftc8inx 528 5 by by IN cord-010092-uftc8inx 528 6 comparison comparison NN cord-010092-uftc8inx 528 7 with with IN cord-010092-uftc8inx 528 8 antibody antibody NN cord-010092-uftc8inx 528 9 - - HYPH cord-010092-uftc8inx 528 10 based base VBN cord-010092-uftc8inx 528 11 typing typing NN cord-010092-uftc8inx 528 12 and and CC cord-010092-uftc8inx 528 13 has have VBZ cord-010092-uftc8inx 528 14 been be VBN cord-010092-uftc8inx 528 15 shown show VBN cord-010092-uftc8inx 528 16 to to TO cord-010092-uftc8inx 528 17 be be VB cord-010092-uftc8inx 528 18 highly highly RB cord-010092-uftc8inx 528 19 correlated correlate VBN cord-010092-uftc8inx 528 20 . . . cord-010092-uftc8inx 529 1 The the DT cord-010092-uftc8inx 529 2 power power NN cord-010092-uftc8inx 529 3 of of IN cord-010092-uftc8inx 529 4 genotyping genotyping NN cord-010092-uftc8inx 529 5 of of IN cord-010092-uftc8inx 529 6 RBCs rbc NNS cord-010092-uftc8inx 529 7 lies lie VBZ cord-010092-uftc8inx 529 8 in in IN cord-010092-uftc8inx 529 9 the the DT cord-010092-uftc8inx 529 10 ability ability NN cord-010092-uftc8inx 529 11 to to TO cord-010092-uftc8inx 529 12 test test VB cord-010092-uftc8inx 529 13 for for IN cord-010092-uftc8inx 529 14 antigens antigen NNS cord-010092-uftc8inx 529 15 for for IN cord-010092-uftc8inx 529 16 which which WDT cord-010092-uftc8inx 529 17 there there EX cord-010092-uftc8inx 529 18 are be VBP cord-010092-uftc8inx 529 19 no no DT cord-010092-uftc8inx 529 20 serologic serologic JJ cord-010092-uftc8inx 529 21 reagents reagent NNS cord-010092-uftc8inx 529 22 , , , cord-010092-uftc8inx 529 23 and and CC cord-010092-uftc8inx 529 24 to to TO cord-010092-uftc8inx 529 25 type type VB cord-010092-uftc8inx 529 26 numerous numerous JJ cord-010092-uftc8inx 529 27 antigens antigen NNS cord-010092-uftc8inx 529 28 in in IN cord-010092-uftc8inx 529 29 a a DT cord-010092-uftc8inx 529 30 single single JJ cord-010092-uftc8inx 529 31 assay assay NN cord-010092-uftc8inx 529 32 using use VBG cord-010092-uftc8inx 529 33 automated automate VBN cord-010092-uftc8inx 529 34 DNA dna NN cord-010092-uftc8inx 529 35 - - HYPH cord-010092-uftc8inx 529 36 arrays array NNS cord-010092-uftc8inx 529 37 . . . cord-010092-uftc8inx 530 1 This this DT cord-010092-uftc8inx 530 2 increases increase VBZ cord-010092-uftc8inx 530 3 accuracy accuracy NN cord-010092-uftc8inx 530 4 and and CC cord-010092-uftc8inx 530 5 weak weak JJ cord-010092-uftc8inx 530 6 antigen antigen NN cord-010092-uftc8inx 530 7 expression expression NN cord-010092-uftc8inx 530 8 can can MD cord-010092-uftc8inx 530 9 be be VB cord-010092-uftc8inx 530 10 revealed reveal VBN cord-010092-uftc8inx 530 11 . . . cord-010092-uftc8inx 531 1 Fresh fresh JJ cord-010092-uftc8inx 531 2 RBC RBC NNP cord-010092-uftc8inx 531 3 samples sample NNS cord-010092-uftc8inx 531 4 are be VBP cord-010092-uftc8inx 531 5 not not RB cord-010092-uftc8inx 531 6 required require VBN cord-010092-uftc8inx 531 7 for for IN cord-010092-uftc8inx 531 8 DNA dna NN cord-010092-uftc8inx 531 9 extraction extraction NN cord-010092-uftc8inx 531 10 , , , cord-010092-uftc8inx 531 11 and and CC cord-010092-uftc8inx 531 12 there there EX cord-010092-uftc8inx 531 13 is be VBZ cord-010092-uftc8inx 531 14 no no DT cord-010092-uftc8inx 531 15 interference interference NN cord-010092-uftc8inx 531 16 from from IN cord-010092-uftc8inx 531 17 transfused transfused JJ cord-010092-uftc8inx 531 18 RBCs rbc NNS cord-010092-uftc8inx 531 19 or or CC cord-010092-uftc8inx 531 20 IgG igg NN cord-010092-uftc8inx 531 21 bound bind VBN cord-010092-uftc8inx 531 22 to to IN cord-010092-uftc8inx 531 23 the the DT cord-010092-uftc8inx 531 24 patient patient NN cord-010092-uftc8inx 531 25 's 's POS cord-010092-uftc8inx 531 26 RBCs rbc NNS cord-010092-uftc8inx 531 27 . . . cord-010092-uftc8inx 532 1 DNAbased dnabase VBN cord-010092-uftc8inx 532 2 typing typing NN cord-010092-uftc8inx 532 3 is be VBZ cord-010092-uftc8inx 532 4 economical economical JJ cord-010092-uftc8inx 532 5 in in IN cord-010092-uftc8inx 532 6 that that IN cord-010092-uftc8inx 532 7 it -PRON- PRP cord-010092-uftc8inx 532 8 provides provide VBZ cord-010092-uftc8inx 532 9 much much RB cord-010092-uftc8inx 532 10 more more JJR cord-010092-uftc8inx 532 11 information information NN cord-010092-uftc8inx 532 12 , , , cord-010092-uftc8inx 532 13 but but CC cord-010092-uftc8inx 532 14 testing testing NN cord-010092-uftc8inx 532 15 requires require VBZ cord-010092-uftc8inx 532 16 special special JJ cord-010092-uftc8inx 532 17 equipment equipment NN cord-010092-uftc8inx 532 18 , , , cord-010092-uftc8inx 532 19 training training NN cord-010092-uftc8inx 532 20 , , , cord-010092-uftc8inx 532 21 and and CC cord-010092-uftc8inx 532 22 24-h 24-h JJ cord-010092-uftc8inx 532 23 turn turn NN cord-010092-uftc8inx 532 24 around around RP cord-010092-uftc8inx 532 25 . . . cord-010092-uftc8inx 533 1 What what WP cord-010092-uftc8inx 533 2 then then RB cord-010092-uftc8inx 533 3 is be VBZ cord-010092-uftc8inx 533 4 the the DT cord-010092-uftc8inx 533 5 best good JJS cord-010092-uftc8inx 533 6 approach approach NN cord-010092-uftc8inx 533 7 to to TO cord-010092-uftc8inx 533 8 use use VB cord-010092-uftc8inx 533 9 ? ? . cord-010092-uftc8inx 534 1 Will Will MD cord-010092-uftc8inx 534 2 serologic serologic NNP cord-010092-uftc8inx 534 3 typing typing NN cord-010092-uftc8inx 534 4 be be VB cord-010092-uftc8inx 534 5 replaced replace VBN cord-010092-uftc8inx 534 6 by by IN cord-010092-uftc8inx 534 7 DNAbased dnabase VBN cord-010092-uftc8inx 534 8 typing typing NN cord-010092-uftc8inx 534 9 ? ? . cord-010092-uftc8inx 535 1 Indeed indeed RB cord-010092-uftc8inx 535 2 , , , cord-010092-uftc8inx 535 3 genotyping genotyping NN cord-010092-uftc8inx 535 4 will will MD cord-010092-uftc8inx 535 5 increasingly increasingly RB cord-010092-uftc8inx 535 6 be be VB cord-010092-uftc8inx 535 7 used use VBN cord-010092-uftc8inx 535 8 in in IN cord-010092-uftc8inx 535 9 the the DT cord-010092-uftc8inx 535 10 practice practice NN cord-010092-uftc8inx 535 11 of of IN cord-010092-uftc8inx 535 12 transfusion transfusion NN cord-010092-uftc8inx 535 13 medicine medicine NN cord-010092-uftc8inx 535 14 , , , cord-010092-uftc8inx 535 15 especially especially RB cord-010092-uftc8inx 535 16 with with IN cord-010092-uftc8inx 535 17 the the DT cord-010092-uftc8inx 535 18 growth growth NN cord-010092-uftc8inx 535 19 of of IN cord-010092-uftc8inx 535 20 whole whole JJ cord-010092-uftc8inx 535 21 genome genome NN cord-010092-uftc8inx 535 22 sequencing sequencing NN cord-010092-uftc8inx 535 23 ( ( -LRB- cord-010092-uftc8inx 535 24 WGS WGS NNP cord-010092-uftc8inx 535 25 ) ) -RRB- cord-010092-uftc8inx 535 26 . . . cord-010092-uftc8inx 536 1 However however RB cord-010092-uftc8inx 536 2 , , , cord-010092-uftc8inx 536 3 because because IN cord-010092-uftc8inx 536 4 serologic serologic NN cord-010092-uftc8inx 536 5 typing typing NN cord-010092-uftc8inx 536 6 for for IN cord-010092-uftc8inx 536 7 ABO ABO NNP cord-010092-uftc8inx 536 8 and and CC cord-010092-uftc8inx 536 9 RhD RhD NNP cord-010092-uftc8inx 536 10 is be VBZ cord-010092-uftc8inx 536 11 fast fast JJ cord-010092-uftc8inx 536 12 and and CC cord-010092-uftc8inx 536 13 accurate accurate JJ cord-010092-uftc8inx 536 14 and and CC cord-010092-uftc8inx 536 15 often often RB cord-010092-uftc8inx 536 16 relied rely VBD cord-010092-uftc8inx 536 17 on on RP cord-010092-uftc8inx 536 18 for for IN cord-010092-uftc8inx 536 19 sample sample NN cord-010092-uftc8inx 536 20 identification identification NN cord-010092-uftc8inx 536 21 , , , cord-010092-uftc8inx 536 22 genotyping genotyping NN cord-010092-uftc8inx 536 23 will will MD cord-010092-uftc8inx 536 24 not not RB cord-010092-uftc8inx 536 25 be be VB cord-010092-uftc8inx 536 26 the the DT cord-010092-uftc8inx 536 27 sole sole JJ cord-010092-uftc8inx 536 28 means mean VBZ cord-010092-uftc8inx 536 29 for for IN cord-010092-uftc8inx 536 30 routine routine JJ cord-010092-uftc8inx 536 31 typing typing NN cord-010092-uftc8inx 536 32 . . . cord-010092-uftc8inx 537 1 Genomic genomic JJ cord-010092-uftc8inx 537 2 sequencing sequencing NN cord-010092-uftc8inx 537 3 approaches approach NNS cord-010092-uftc8inx 537 4 will will MD cord-010092-uftc8inx 537 5 certainly certainly RB cord-010092-uftc8inx 537 6 reveal reveal VB cord-010092-uftc8inx 537 7 unrecognized unrecognized JJ cord-010092-uftc8inx 537 8 changes change NNS cord-010092-uftc8inx 537 9 and and CC cord-010092-uftc8inx 537 10 genetic genetic JJ cord-010092-uftc8inx 537 11 variability variability NN cord-010092-uftc8inx 537 12 in in IN cord-010092-uftc8inx 537 13 RBC RBC NNP cord-010092-uftc8inx 537 14 membrane membrane NN cord-010092-uftc8inx 537 15 proteins protein NNS cord-010092-uftc8inx 537 16 , , , cord-010092-uftc8inx 537 17 but but CC cord-010092-uftc8inx 537 18 not not RB cord-010092-uftc8inx 537 19 all all DT cord-010092-uftc8inx 537 20 variation variation NN cord-010092-uftc8inx 537 21 will will MD cord-010092-uftc8inx 537 22 be be VB cord-010092-uftc8inx 537 23 immunogenic immunogenic JJ cord-010092-uftc8inx 537 24 . . . cord-010092-uftc8inx 538 1 A a DT cord-010092-uftc8inx 538 2 genetic genetic JJ cord-010092-uftc8inx 538 3 polymorphism polymorphism NN cord-010092-uftc8inx 538 4 must must MD cord-010092-uftc8inx 538 5 be be VB cord-010092-uftc8inx 538 6 associated associate VBN cord-010092-uftc8inx 538 7 with with IN cord-010092-uftc8inx 538 8 antibody antibody NN cord-010092-uftc8inx 538 9 production production NN cord-010092-uftc8inx 538 10 to to TO cord-010092-uftc8inx 538 11 be be VB cord-010092-uftc8inx 538 12 considered consider VBN cord-010092-uftc8inx 538 13 a a DT cord-010092-uftc8inx 538 14 blood blood NN cord-010092-uftc8inx 538 15 group group NN cord-010092-uftc8inx 538 16 antigen antigen NN cord-010092-uftc8inx 538 17 . . . cord-010092-uftc8inx 539 1 The the DT cord-010092-uftc8inx 539 2 importance importance NN cord-010092-uftc8inx 539 3 of of IN cord-010092-uftc8inx 539 4 an an DT cord-010092-uftc8inx 539 5 antibody antibody NN cord-010092-uftc8inx 539 6 , , , cord-010092-uftc8inx 539 7 and and CC cord-010092-uftc8inx 539 8 antibody antibody NN cord-010092-uftc8inx 539 9 reactivity reactivity NN cord-010092-uftc8inx 539 10 , , , cord-010092-uftc8inx 539 11 then then RB cord-010092-uftc8inx 539 12 will will MD cord-010092-uftc8inx 539 13 continue continue VB cord-010092-uftc8inx 539 14 to to TO cord-010092-uftc8inx 539 15 be be VB cord-010092-uftc8inx 539 16 the the DT cord-010092-uftc8inx 539 17 central central JJ cord-010092-uftc8inx 539 18 defining define VBG cord-010092-uftc8inx 539 19 principal principal NN cord-010092-uftc8inx 539 20 in in IN cord-010092-uftc8inx 539 21 transfusion transfusion NN cord-010092-uftc8inx 539 22 . . . cord-010092-uftc8inx 540 1 As as IN cord-010092-uftc8inx 540 2 two two CD cord-010092-uftc8inx 540 3 sides side NNS cord-010092-uftc8inx 540 4 of of IN cord-010092-uftc8inx 540 5 a a DT cord-010092-uftc8inx 540 6 coin coin NN cord-010092-uftc8inx 540 7 , , , cord-010092-uftc8inx 540 8 both both DT cord-010092-uftc8inx 540 9 are be VBP cord-010092-uftc8inx 540 10 key key JJ cord-010092-uftc8inx 540 11 to to IN cord-010092-uftc8inx 540 12 safe safe JJ cord-010092-uftc8inx 540 13 and and CC cord-010092-uftc8inx 540 14 effective effective JJ cord-010092-uftc8inx 540 15 transfusion transfusion NN cord-010092-uftc8inx 540 16 therapy therapy NN cord-010092-uftc8inx 540 17 . . . cord-010092-uftc8inx 541 1 Since since IN cord-010092-uftc8inx 541 2 the the DT cord-010092-uftc8inx 541 3 mid-1980s mid-1980 NNS cord-010092-uftc8inx 541 4 , , , cord-010092-uftc8inx 541 5 research research NN cord-010092-uftc8inx 541 6 in in IN cord-010092-uftc8inx 541 7 the the DT cord-010092-uftc8inx 541 8 molecular molecular JJ cord-010092-uftc8inx 541 9 basis basis NN cord-010092-uftc8inx 541 10 of of IN cord-010092-uftc8inx 541 11 structural structural JJ cord-010092-uftc8inx 541 12 and and CC cord-010092-uftc8inx 541 13 functional functional JJ cord-010092-uftc8inx 541 14 aspects aspect NNS cord-010092-uftc8inx 541 15 of of IN cord-010092-uftc8inx 541 16 proteins protein NNS cord-010092-uftc8inx 541 17 carrying carry VBG cord-010092-uftc8inx 541 18 and and CC cord-010092-uftc8inx 541 19 producing produce VBG cord-010092-uftc8inx 541 20 the the DT cord-010092-uftc8inx 541 21 antigens antigen NNS cord-010092-uftc8inx 541 22 has have VBZ cord-010092-uftc8inx 541 23 led lead VBN cord-010092-uftc8inx 541 24 to to IN cord-010092-uftc8inx 541 25 an an DT cord-010092-uftc8inx 541 26 upgraded upgraded JJ cord-010092-uftc8inx 541 27 and and CC cord-010092-uftc8inx 541 28 modern modern JJ cord-010092-uftc8inx 541 29 understanding understanding NN cord-010092-uftc8inx 541 30 of of IN cord-010092-uftc8inx 541 31 blood blood NN cord-010092-uftc8inx 541 32 group group NN cord-010092-uftc8inx 541 33 variation variation NN cord-010092-uftc8inx 541 34 . . . cord-010092-uftc8inx 542 1 Most most RBS cord-010092-uftc8inx 542 2 commonly commonly RB cord-010092-uftc8inx 542 3 , , , cord-010092-uftc8inx 542 4 single single JJ cord-010092-uftc8inx 542 5 nucleotide nucleotide JJ cord-010092-uftc8inx 542 6 polymorphism polymorphism NN cord-010092-uftc8inx 542 7 ( ( -LRB- cord-010092-uftc8inx 542 8 SNP SNP NNP cord-010092-uftc8inx 542 9 ) ) -RRB- cord-010092-uftc8inx 543 1 based base VBN cord-010092-uftc8inx 543 2 basic basic JJ cord-010092-uftc8inx 543 3 molecular molecular JJ cord-010092-uftc8inx 543 4 typing typing NN cord-010092-uftc8inx 543 5 techniques technique NNS cord-010092-uftc8inx 543 6 were be VBD cord-010092-uftc8inx 543 7 utilized utilize VBN cord-010092-uftc8inx 543 8 to to TO cord-010092-uftc8inx 543 9 test test VB cord-010092-uftc8inx 543 10 new new JJ cord-010092-uftc8inx 543 11 findings finding NNS cord-010092-uftc8inx 543 12 on on IN cord-010092-uftc8inx 543 13 a a DT cord-010092-uftc8inx 543 14 smaller small JJR cord-010092-uftc8inx 543 15 subset subset JJ cord-010092-uftc8inx 543 16 of of IN cord-010092-uftc8inx 543 17 samples sample NNS cord-010092-uftc8inx 543 18 , , , cord-010092-uftc8inx 543 19 and and CC cord-010092-uftc8inx 543 20 resulted result VBD cord-010092-uftc8inx 543 21 in in IN cord-010092-uftc8inx 543 22 concordant concordant JJ cord-010092-uftc8inx 543 23 sero sero NN cord-010092-uftc8inx 543 24 - - HYPH cord-010092-uftc8inx 543 25 and and CC cord-010092-uftc8inx 543 26 genotyping genotyping NN cord-010092-uftc8inx 543 27 results result NNS cord-010092-uftc8inx 543 28 in in IN cord-010092-uftc8inx 543 29 general general JJ cord-010092-uftc8inx 543 30 . . . cord-010092-uftc8inx 544 1 However however RB cord-010092-uftc8inx 544 2 , , , cord-010092-uftc8inx 544 3 quite quite RB cord-010092-uftc8inx 544 4 commonly commonly RB cord-010092-uftc8inx 544 5 a a DT cord-010092-uftc8inx 544 6 small small JJ cord-010092-uftc8inx 544 7 number number NN cord-010092-uftc8inx 544 8 of of IN cord-010092-uftc8inx 544 9 all all DT cord-010092-uftc8inx 544 10 samples sample NNS cord-010092-uftc8inx 544 11 delivered deliver VBD cord-010092-uftc8inx 544 12 discrepant discrepant JJ cord-010092-uftc8inx 544 13 results result NNS cord-010092-uftc8inx 544 14 , , , cord-010092-uftc8inx 544 15 triggering trigger VBG cord-010092-uftc8inx 544 16 consecutive consecutive JJ cord-010092-uftc8inx 544 17 rounds round NNS cord-010092-uftc8inx 544 18 of of IN cord-010092-uftc8inx 544 19 analysis analysis NN cord-010092-uftc8inx 544 20 and and CC cord-010092-uftc8inx 544 21 resolution resolution NN cord-010092-uftc8inx 544 22 , , , cord-010092-uftc8inx 544 23 finally finally RB cord-010092-uftc8inx 544 24 resulting result VBG cord-010092-uftc8inx 544 25 in in IN cord-010092-uftc8inx 544 26 a a DT cord-010092-uftc8inx 544 27 better well JJR cord-010092-uftc8inx 544 28 knowledge knowledge NN cord-010092-uftc8inx 544 29 with with IN cord-010092-uftc8inx 544 30 respect respect NN cord-010092-uftc8inx 544 31 to to IN cord-010092-uftc8inx 544 32 the the DT cord-010092-uftc8inx 544 33 underlying underlie VBG cord-010092-uftc8inx 544 34 blood blood NN cord-010092-uftc8inx 544 35 group group NN cord-010092-uftc8inx 544 36 variation variation NN cord-010092-uftc8inx 544 37 . . . cord-010092-uftc8inx 545 1 Such such JJ cord-010092-uftc8inx 545 2 rounds round NNS cord-010092-uftc8inx 545 3 of of IN cord-010092-uftc8inx 545 4 repetitions repetition NNS cord-010092-uftc8inx 545 5 represented represent VBD cord-010092-uftc8inx 545 6 the the DT cord-010092-uftc8inx 545 7 synergistic synergistic JJ cord-010092-uftc8inx 545 8 incremental incremental JJ cord-010092-uftc8inx 545 9 process process NN cord-010092-uftc8inx 545 10 of of IN cord-010092-uftc8inx 545 11 learning learning NN cord-010092-uftc8inx 545 12 , , , cord-010092-uftc8inx 545 13 learning learn VBG cord-010092-uftc8inx 545 14 for for IN cord-010092-uftc8inx 545 15 serologists serologist NNS cord-010092-uftc8inx 545 16 and and CC cord-010092-uftc8inx 545 17 molecular molecular JJ cord-010092-uftc8inx 545 18 biologists biologist NNS cord-010092-uftc8inx 545 19 . . . cord-010092-uftc8inx 546 1 Inheritance inheritance NN cord-010092-uftc8inx 546 2 of of IN cord-010092-uftc8inx 546 3 public public JJ cord-010092-uftc8inx 546 4 , , , cord-010092-uftc8inx 546 5 presence presence NN cord-010092-uftc8inx 546 6 of of IN cord-010092-uftc8inx 546 7 high high JJ cord-010092-uftc8inx 546 8 frequency frequency NN cord-010092-uftc8inx 546 9 , , , cord-010092-uftc8inx 546 10 or or CC cord-010092-uftc8inx 546 11 low low JJ cord-010092-uftc8inx 546 12 frequency frequency NN cord-010092-uftc8inx 546 13 , , , cord-010092-uftc8inx 546 14 or or CC cord-010092-uftc8inx 546 15 partial partial JJ cord-010092-uftc8inx 546 16 antigens antigen NNS cord-010092-uftc8inx 546 17 and and CC cord-010092-uftc8inx 546 18 notice notice NN cord-010092-uftc8inx 546 19 of of IN cord-010092-uftc8inx 546 20 weakly weakly RB cord-010092-uftc8inx 546 21 expressed express VBN cord-010092-uftc8inx 546 22 , , , cord-010092-uftc8inx 546 23 or or CC cord-010092-uftc8inx 546 24 almost almost RB cord-010092-uftc8inx 546 25 undetectable undetectable JJ cord-010092-uftc8inx 546 26 antigens antigen NNS cord-010092-uftc8inx 546 27 marked mark VBD cord-010092-uftc8inx 546 28 the the DT cord-010092-uftc8inx 546 29 path path NN cord-010092-uftc8inx 546 30 of of IN cord-010092-uftc8inx 546 31 incremental incremental JJ cord-010092-uftc8inx 546 32 learning learning NN cord-010092-uftc8inx 546 33 and and CC cord-010092-uftc8inx 546 34 may may MD cord-010092-uftc8inx 546 35 best best RB cord-010092-uftc8inx 546 36 be be VB cord-010092-uftc8inx 546 37 exemplified exemplify VBN cord-010092-uftc8inx 546 38 by by IN cord-010092-uftc8inx 546 39 discoveries discovery NNS cord-010092-uftc8inx 546 40 within within IN cord-010092-uftc8inx 546 41 the the DT cord-010092-uftc8inx 546 42 blood blood NN cord-010092-uftc8inx 546 43 group group NN cord-010092-uftc8inx 546 44 systems system NNS cord-010092-uftc8inx 546 45 ABO ABO NNP cord-010092-uftc8inx 546 46 , , , cord-010092-uftc8inx 546 47 RhD rhd NN cord-010092-uftc8inx 546 48 and and CC cord-010092-uftc8inx 546 49 Kell Kell NNP cord-010092-uftc8inx 546 50 . . . cord-010092-uftc8inx 547 1 Naming name VBG cord-010092-uftc8inx 547 2 for for IN cord-010092-uftc8inx 547 3 pheno pheno NN cord-010092-uftc8inx 547 4 - - : cord-010092-uftc8inx 547 5 and and CC cord-010092-uftc8inx 547 6 genotypes genotype NNS cord-010092-uftc8inx 547 7 coevolved coevolve VBN cord-010092-uftc8inx 547 8 alongside alongside IN cord-010092-uftc8inx 547 9 the the DT cord-010092-uftc8inx 547 10 permanent permanent JJ cord-010092-uftc8inx 547 11 discovery discovery NN cord-010092-uftc8inx 547 12 of of IN cord-010092-uftc8inx 547 13 new new JJ cord-010092-uftc8inx 547 14 antigens antigen NNS cord-010092-uftc8inx 547 15 . . . cord-010092-uftc8inx 548 1 At at IN cord-010092-uftc8inx 548 2 present present JJ cord-010092-uftc8inx 548 3 , , , cord-010092-uftc8inx 548 4 antigens antigen NNS cord-010092-uftc8inx 548 5 and and CC cord-010092-uftc8inx 548 6 their -PRON- PRP$ cord-010092-uftc8inx 548 7 antithetic antithetic JJ cord-010092-uftc8inx 548 8 counterparts counterpart NNS cord-010092-uftc8inx 548 9 ( ( -LRB- cord-010092-uftc8inx 548 10 if if IN cord-010092-uftc8inx 548 11 tested test VBN cord-010092-uftc8inx 548 12 and and CC cord-010092-uftc8inx 548 13 if if IN cord-010092-uftc8inx 548 14 existent existent JJ cord-010092-uftc8inx 548 15 ) ) -RRB- cord-010092-uftc8inx 548 16 , , , cord-010092-uftc8inx 548 17 are be VBP cord-010092-uftc8inx 548 18 more more RBR cord-010092-uftc8inx 548 19 commonly commonly RB cord-010092-uftc8inx 548 20 reported report VBN cord-010092-uftc8inx 548 21 independently independently RB cord-010092-uftc8inx 548 22 , , , cord-010092-uftc8inx 548 23 as as IN cord-010092-uftc8inx 548 24 exemplarily exemplarily RB cord-010092-uftc8inx 548 25 shown show VBN cord-010092-uftc8inx 548 26 for for IN cord-010092-uftc8inx 548 27 the the DT cord-010092-uftc8inx 548 28 following follow VBG cord-010092-uftc8inx 548 29 Kell Kell NNP cord-010092-uftc8inx 548 30 phenotype phenotype NN cord-010092-uftc8inx 548 31 consisting consist VBG cord-010092-uftc8inx 548 32 of of IN cord-010092-uftc8inx 548 33 three three CD cord-010092-uftc8inx 548 34 antithetic antithetic JJ cord-010092-uftc8inx 548 35 antigen antigen NN cord-010092-uftc8inx 548 36 - - HYPH cord-010092-uftc8inx 548 37 couples couple NNS cord-010092-uftc8inx 548 38 : : : cord-010092-uftc8inx 548 39 kk kk NNP cord-010092-uftc8inx 548 40 , , , cord-010092-uftc8inx 548 41 Kp Kp NNP cord-010092-uftc8inx 548 42 ( ( -LRB- cord-010092-uftc8inx 548 43 a+b+ a+b+ CD cord-010092-uftc8inx 548 44 ) ) -RRB- cord-010092-uftc8inx 548 45 , , , cord-010092-uftc8inx 548 46 Js(a+b+ Js(a+b+ NNP cord-010092-uftc8inx 548 47 ) ) -RRB- cord-010092-uftc8inx 548 48 . . . cord-010092-uftc8inx 549 1 Alternatively alternatively RB cord-010092-uftc8inx 549 2 , , , cord-010092-uftc8inx 549 3 the the DT cord-010092-uftc8inx 549 4 same same JJ cord-010092-uftc8inx 549 5 phenotype phenotype NN cord-010092-uftc8inx 549 6 could could MD cord-010092-uftc8inx 549 7 be be VB cord-010092-uftc8inx 549 8 stated state VBN cord-010092-uftc8inx 549 9 as as IN cord-010092-uftc8inx 549 10 : : : cord-010092-uftc8inx 549 11 KEL:-1,2,3,4 KEL:-1,2,3,4 NNP cord-010092-uftc8inx 549 12 , , , cord-010092-uftc8inx 549 13 ( ( -LRB- cord-010092-uftc8inx 549 14 5),6,7 5),6,7 CD cord-010092-uftc8inx 549 15 . . . cord-010092-uftc8inx 550 1 Genotypes Genotypes NNP cord-010092-uftc8inx 550 2 , , , cord-010092-uftc8inx 550 3 on on IN cord-010092-uftc8inx 550 4 the the DT cord-010092-uftc8inx 550 5 other other JJ cord-010092-uftc8inx 550 6 hand hand NN cord-010092-uftc8inx 550 7 , , , cord-010092-uftc8inx 550 8 rather rather RB cord-010092-uftc8inx 550 9 mirror mirror VB cord-010092-uftc8inx 550 10 the the DT cord-010092-uftc8inx 550 11 actual actual JJ cord-010092-uftc8inx 550 12 biological biological JJ cord-010092-uftc8inx 550 13 background background NN cord-010092-uftc8inx 550 14 , , , cord-010092-uftc8inx 551 1 e.g. e.g. RB cord-010092-uftc8inx 551 2 display display VB cord-010092-uftc8inx 551 3 the the DT cord-010092-uftc8inx 551 4 two two CD cord-010092-uftc8inx 551 5 parental parental JJ cord-010092-uftc8inx 551 6 alleles allele NNS cord-010092-uftc8inx 551 7 ( ( -LRB- cord-010092-uftc8inx 551 8 or or CC cord-010092-uftc8inx 551 9 " " `` cord-010092-uftc8inx 551 10 haplotypes haplotype NNS cord-010092-uftc8inx 551 11 " " '' cord-010092-uftc8inx 551 12 ) ) -RRB- cord-010092-uftc8inx 551 13 present present JJ cord-010092-uftc8inx 551 14 in in IN cord-010092-uftc8inx 551 15 an an DT cord-010092-uftc8inx 551 16 individuals individual NNS cord-010092-uftc8inx 551 17 ' ' POS cord-010092-uftc8inx 551 18 sample sample NN cord-010092-uftc8inx 551 19 . . . cord-010092-uftc8inx 552 1 Genotype genotype NN cord-010092-uftc8inx 552 2 of of IN cord-010092-uftc8inx 552 3 the the DT cord-010092-uftc8inx 552 4 above above RB cord-010092-uftc8inx 552 5 mentioned mention VBN cord-010092-uftc8inx 552 6 example example NN cord-010092-uftc8inx 552 7 would would MD cord-010092-uftc8inx 552 8 read read VB cord-010092-uftc8inx 552 9 : : : cord-010092-uftc8inx 552 10 KEL*02.03/ KEL*02.03/ NNP cord-010092-uftc8inx 552 11 02.06 02.06 CD cord-010092-uftc8inx 552 12 ( ( -LRB- cord-010092-uftc8inx 552 13 italicized italicize VBN cord-010092-uftc8inx 552 14 ) ) -RRB- cord-010092-uftc8inx 552 15 . . . cord-010092-uftc8inx 553 1 In in IN cord-010092-uftc8inx 553 2 an an DT cord-010092-uftc8inx 553 3 idealized idealized JJ cord-010092-uftc8inx 553 4 diagnostic diagnostic JJ cord-010092-uftc8inx 553 5 environment environment NN cord-010092-uftc8inx 553 6 and and CC cord-010092-uftc8inx 553 7 for for IN cord-010092-uftc8inx 553 8 most most JJS cord-010092-uftc8inx 553 9 blood blood NN cord-010092-uftc8inx 553 10 group group NN cord-010092-uftc8inx 553 11 systems system NNS cord-010092-uftc8inx 553 12 encoded encode VBN cord-010092-uftc8inx 553 13 by by IN cord-010092-uftc8inx 553 14 proteins protein NNS cord-010092-uftc8inx 553 15 , , , cord-010092-uftc8inx 553 16 every every DT cord-010092-uftc8inx 553 17 single single JJ cord-010092-uftc8inx 553 18 blood blood NN cord-010092-uftc8inx 553 19 group group NN cord-010092-uftc8inx 553 20 allele allele NN cord-010092-uftc8inx 553 21 would would MD cord-010092-uftc8inx 553 22 be be VB cord-010092-uftc8inx 553 23 defined define VBN cord-010092-uftc8inx 553 24 by by IN cord-010092-uftc8inx 553 25 its -PRON- PRP$ cord-010092-uftc8inx 553 26 full full JJ cord-010092-uftc8inx 553 27 genomic genomic JJ cord-010092-uftc8inx 553 28 sequence sequence NN cord-010092-uftc8inx 553 29 , , , cord-010092-uftc8inx 553 30 derived derive VBN cord-010092-uftc8inx 553 31 from from IN cord-010092-uftc8inx 553 32 one one CD cord-010092-uftc8inx 553 33 parental parental JJ cord-010092-uftc8inx 553 34 chromosome chromosome NN cord-010092-uftc8inx 553 35 ( ( -LRB- cord-010092-uftc8inx 553 36 including include VBG cord-010092-uftc8inx 553 37 " " `` cord-010092-uftc8inx 553 38 some some DT cord-010092-uftc8inx 553 39 " " '' cord-010092-uftc8inx 553 40 5'and 5'and CD cord-010092-uftc8inx 553 41 3'-untranslated 3'-untranslated JJ cord-010092-uftc8inx 553 42 regions region NNS cord-010092-uftc8inx 553 43 ) ) -RRB- cord-010092-uftc8inx 553 44 . . . cord-010092-uftc8inx 554 1 Thereby thereby RB cord-010092-uftc8inx 554 2 , , , cord-010092-uftc8inx 554 3 every every DT cord-010092-uftc8inx 554 4 such such JJ cord-010092-uftc8inx 554 5 " " `` cord-010092-uftc8inx 554 6 ideal ideal JJ cord-010092-uftc8inx 554 7 allele allele NN cord-010092-uftc8inx 554 8 " " '' cord-010092-uftc8inx 554 9 would would MD cord-010092-uftc8inx 554 10 fully fully RB cord-010092-uftc8inx 554 11 declare declare VB cord-010092-uftc8inx 554 12 presence presence NN cord-010092-uftc8inx 554 13 or or CC cord-010092-uftc8inx 554 14 absence absence NN cord-010092-uftc8inx 554 15 of of IN cord-010092-uftc8inx 554 16 all all PDT cord-010092-uftc8inx 554 17 its -PRON- PRP$ cord-010092-uftc8inx 554 18 public public JJ cord-010092-uftc8inx 554 19 , , , cord-010092-uftc8inx 554 20 low low JJ cord-010092-uftc8inx 554 21 - - HYPH cord-010092-uftc8inx 554 22 and and CC cord-010092-uftc8inx 554 23 high high JJ cord-010092-uftc8inx 554 24 - - HYPH cord-010092-uftc8inx 554 25 frequency frequency NN cord-010092-uftc8inx 554 26 antigens antigen NNS cord-010092-uftc8inx 554 27 and and CC cord-010092-uftc8inx 554 28 possess possess VBP cord-010092-uftc8inx 554 29 its -PRON- PRP$ cord-010092-uftc8inx 554 30 " " `` cord-010092-uftc8inx 554 31 ideal ideal JJ cord-010092-uftc8inx 554 32 name name NN cord-010092-uftc8inx 554 33 " " '' cord-010092-uftc8inx 554 34 . . . cord-010092-uftc8inx 555 1 By by IN cord-010092-uftc8inx 555 2 trend trend NN cord-010092-uftc8inx 555 3 , , , cord-010092-uftc8inx 555 4 biallelic biallelic NNP cord-010092-uftc8inx 555 5 SNPs SNPs NNPS cord-010092-uftc8inx 555 6 and and CC cord-010092-uftc8inx 555 7 their -PRON- PRP$ cord-010092-uftc8inx 555 8 immediate immediate JJ cord-010092-uftc8inx 555 9 relation relation NN cord-010092-uftc8inx 555 10 to to IN cord-010092-uftc8inx 555 11 antithetic antithetic JJ cord-010092-uftc8inx 555 12 antigen antigen NN cord-010092-uftc8inx 555 13 couples couple NNS cord-010092-uftc8inx 555 14 might may MD cord-010092-uftc8inx 555 15 have have VB cord-010092-uftc8inx 555 16 distracted distract VBN cord-010092-uftc8inx 555 17 from from IN cord-010092-uftc8inx 555 18 the the DT cord-010092-uftc8inx 555 19 originally originally RB cord-010092-uftc8inx 555 20 intended intend VBN cord-010092-uftc8inx 555 21 meaning meaning NN cord-010092-uftc8inx 555 22 of of IN cord-010092-uftc8inx 555 23 " " `` cord-010092-uftc8inx 555 24 blood blood NN cord-010092-uftc8inx 555 25 group group NN cord-010092-uftc8inx 555 26 alleles allele NNS cord-010092-uftc8inx 555 27 " " '' cord-010092-uftc8inx 555 28 , , , cord-010092-uftc8inx 555 29 more more RBR cord-010092-uftc8inx 555 30 recently recently RB cord-010092-uftc8inx 555 31 . . . cord-010092-uftc8inx 556 1 Finally finally RB cord-010092-uftc8inx 556 2 , , , cord-010092-uftc8inx 556 3 genotypes genotype NNS cord-010092-uftc8inx 556 4 only only RB cord-010092-uftc8inx 556 5 dependent dependent JJ cord-010092-uftc8inx 556 6 on on IN cord-010092-uftc8inx 556 7 ( ( -LRB- cord-010092-uftc8inx 556 8 ideal ideal JJ cord-010092-uftc8inx 556 9 ) ) -RRB- cord-010092-uftc8inx 556 10 allele allele NN cord-010092-uftc8inx 556 11 names name NNS cord-010092-uftc8inx 556 12 , , , cord-010092-uftc8inx 556 13 and and CC cord-010092-uftc8inx 556 14 considering consider VBG cord-010092-uftc8inx 556 15 Mendelian mendelian JJ cord-010092-uftc8inx 556 16 inheritance inheritance NN cord-010092-uftc8inx 556 17 patterns pattern NNS cord-010092-uftc8inx 556 18 ( ( -LRB- cord-010092-uftc8inx 556 19 dominant dominant JJ cord-010092-uftc8inx 556 20 , , , cord-010092-uftc8inx 556 21 recessive recessive JJ cord-010092-uftc8inx 556 22 ) ) -RRB- cord-010092-uftc8inx 556 23 , , , cord-010092-uftc8inx 556 24 would would MD cord-010092-uftc8inx 556 25 allow allow VB cord-010092-uftc8inx 556 26 for for IN cord-010092-uftc8inx 556 27 fully fully RB cord-010092-uftc8inx 556 28 comprehensive comprehensive JJ cord-010092-uftc8inx 556 29 phenotype phenotype NN cord-010092-uftc8inx 556 30 predictions prediction NNS cord-010092-uftc8inx 556 31 . . . cord-010092-uftc8inx 557 1 More more RBR cord-010092-uftc8inx 557 2 recently recently RB cord-010092-uftc8inx 557 3 , , , cord-010092-uftc8inx 557 4 blood blood NN cord-010092-uftc8inx 557 5 group group NN cord-010092-uftc8inx 557 6 serology serology NN cord-010092-uftc8inx 557 7 , , , cord-010092-uftc8inx 557 8 e.g. e.g. RB cord-010092-uftc8inx 557 9 the the DT cord-010092-uftc8inx 557 10 " " `` cord-010092-uftc8inx 557 11 second second JJ cord-010092-uftc8inx 557 12 side side NN cord-010092-uftc8inx 557 13 of of IN cord-010092-uftc8inx 557 14 the the DT cord-010092-uftc8inx 557 15 coin coin NN cord-010092-uftc8inx 557 16 " " '' cord-010092-uftc8inx 557 17 , , , cord-010092-uftc8inx 557 18 seems seem VBZ cord-010092-uftc8inx 557 19 to to TO cord-010092-uftc8inx 557 20 gain gain VB cord-010092-uftc8inx 557 21 momentum momentum NN cord-010092-uftc8inx 557 22 . . . cord-010092-uftc8inx 558 1 Since since IN cord-010092-uftc8inx 558 2 the the DT cord-010092-uftc8inx 558 3 advent advent NN cord-010092-uftc8inx 558 4 of of IN cord-010092-uftc8inx 558 5 whole whole JJ cord-010092-uftc8inx 558 6 genome genome NN cord-010092-uftc8inx 558 7 sequencing sequencing NN cord-010092-uftc8inx 558 8 and and CC cord-010092-uftc8inx 558 9 access access NN cord-010092-uftc8inx 558 10 to to IN cord-010092-uftc8inx 558 11 many many JJ cord-010092-uftc8inx 558 12 more more JJR cord-010092-uftc8inx 558 13 than than IN cord-010092-uftc8inx 558 14 1000 1000 CD cord-010092-uftc8inx 558 15 human human JJ cord-010092-uftc8inx 558 16 genomes genome NNS cord-010092-uftc8inx 558 17 , , , cord-010092-uftc8inx 558 18 it -PRON- PRP cord-010092-uftc8inx 558 19 seems seem VBZ cord-010092-uftc8inx 558 20 that that IN cord-010092-uftc8inx 558 21 dozens dozen NNS cord-010092-uftc8inx 558 22 of of IN cord-010092-uftc8inx 558 23 new new JJ cord-010092-uftc8inx 558 24 blood blood NN cord-010092-uftc8inx 558 25 group group NN cord-010092-uftc8inx 558 26 alleles allele NNS cord-010092-uftc8inx 558 27 are be VBP cord-010092-uftc8inx 558 28 discovered discover VBN cord-010092-uftc8inx 558 29 , , , cord-010092-uftc8inx 558 30 almost almost RB cord-010092-uftc8inx 558 31 on on IN cord-010092-uftc8inx 558 32 a a DT cord-010092-uftc8inx 558 33 daily daily JJ cord-010092-uftc8inx 558 34 basis basis NN cord-010092-uftc8inx 558 35 . . . cord-010092-uftc8inx 559 1 Beside beside IN cord-010092-uftc8inx 559 2 the the DT cord-010092-uftc8inx 559 3 challenge challenge NN cord-010092-uftc8inx 559 4 of of IN cord-010092-uftc8inx 559 5 naming name VBG cord-010092-uftc8inx 559 6 this this DT cord-010092-uftc8inx 559 7 multitude multitude NN cord-010092-uftc8inx 559 8 of of IN cord-010092-uftc8inx 559 9 alleles allele NNS cord-010092-uftc8inx 559 10 , , , cord-010092-uftc8inx 559 11 respective respective JJ cord-010092-uftc8inx 559 12 discoveries discovery NNS cord-010092-uftc8inx 559 13 are be VBP cord-010092-uftc8inx 559 14 frequently frequently RB cord-010092-uftc8inx 559 15 made make VBN cord-010092-uftc8inx 559 16 in in IN cord-010092-uftc8inx 559 17 samples sample NNS cord-010092-uftc8inx 559 18 lacking lack VBG cord-010092-uftc8inx 559 19 any any DT cord-010092-uftc8inx 559 20 phenotypic phenotypic JJ cord-010092-uftc8inx 559 21 blood blood NN cord-010092-uftc8inx 559 22 group group NN cord-010092-uftc8inx 559 23 pre pre NNS cord-010092-uftc8inx 559 24 - - NNS cord-010092-uftc8inx 559 25 values value NNS cord-010092-uftc8inx 559 26 . . . cord-010092-uftc8inx 560 1 Clear clear JJ cord-010092-uftc8inx 560 2 procedures procedure NNS cord-010092-uftc8inx 560 3 will will MD cord-010092-uftc8inx 560 4 be be VB cord-010092-uftc8inx 560 5 needed need VBN cord-010092-uftc8inx 560 6 to to TO cord-010092-uftc8inx 560 7 address address VB cord-010092-uftc8inx 560 8 naming naming NN cord-010092-uftc8inx 560 9 and and CC cord-010092-uftc8inx 560 10 analyzing analyze VBG cord-010092-uftc8inx 560 11 the the DT cord-010092-uftc8inx 560 12 phenotypes phenotype NNS cord-010092-uftc8inx 560 13 resulting result VBG cord-010092-uftc8inx 560 14 from from IN cord-010092-uftc8inx 560 15 previously previously RB cord-010092-uftc8inx 560 16 unknown unknown JJ cord-010092-uftc8inx 560 17 alleles allele NNS cord-010092-uftc8inx 560 18 . . . cord-010092-uftc8inx 561 1 As as IN cord-010092-uftc8inx 561 2 a a DT cord-010092-uftc8inx 561 3 consequence consequence NN cord-010092-uftc8inx 561 4 , , , cord-010092-uftc8inx 561 5 questions question NNS cord-010092-uftc8inx 561 6 asked ask VBD cord-010092-uftc8inx 561 7 30 30 CD cord-010092-uftc8inx 561 8 years year NNS cord-010092-uftc8inx 561 9 ago ago RB cord-010092-uftc8inx 561 10 have have VBP cord-010092-uftc8inx 561 11 changed change VBN cord-010092-uftc8inx 561 12 : : : cord-010092-uftc8inx 561 13 Today today NN cord-010092-uftc8inx 561 14 , , , cord-010092-uftc8inx 561 15 molecular molecular JJ cord-010092-uftc8inx 561 16 biologists biologist NNS cord-010092-uftc8inx 561 17 looking look VBG cord-010092-uftc8inx 561 18 at at IN cord-010092-uftc8inx 561 19 hundreds hundred NNS cord-010092-uftc8inx 561 20 of of IN cord-010092-uftc8inx 561 21 newly newly RB cord-010092-uftc8inx 561 22 discovered discover VBN cord-010092-uftc8inx 561 23 blood blood NN cord-010092-uftc8inx 561 24 group group NN cord-010092-uftc8inx 561 25 alleles allele NNS cord-010092-uftc8inx 561 26 find find VBP cord-010092-uftc8inx 561 27 themselves -PRON- PRP cord-010092-uftc8inx 561 28 not not RB cord-010092-uftc8inx 561 29 being be VBG cord-010092-uftc8inx 561 30 asked ask VBN cord-010092-uftc8inx 561 31 by by IN cord-010092-uftc8inx 561 32 serologists serologists NNP cord-010092-uftc8inx 561 33 any any DT cord-010092-uftc8inx 561 34 more more RBR cord-010092-uftc8inx 561 35 : : : cord-010092-uftc8inx 561 36 " " `` cord-010092-uftc8inx 561 37 Can Can MD cord-010092-uftc8inx 561 38 you -PRON- PRP cord-010092-uftc8inx 561 39 confirm confirm VB cord-010092-uftc8inx 561 40 my -PRON- PRP$ cord-010092-uftc8inx 561 41 serology serology NN cord-010092-uftc8inx 561 42 ? ? . cord-010092-uftc8inx 561 43 " " '' cord-010092-uftc8inx 561 44 , , , cord-010092-uftc8inx 561 45 but but CC cord-010092-uftc8inx 561 46 instead instead RB cord-010092-uftc8inx 561 47 , , , cord-010092-uftc8inx 561 48 pose pose VBP cord-010092-uftc8inx 561 49 their -PRON- PRP$ cord-010092-uftc8inx 561 50 question question NN cord-010092-uftc8inx 561 51 to to IN cord-010092-uftc8inx 561 52 the the DT cord-010092-uftc8inx 561 53 experts expert NNS cord-010092-uftc8inx 561 54 for for IN cord-010092-uftc8inx 561 55 the the DT cord-010092-uftc8inx 561 56 blood blood NN cord-010092-uftc8inx 561 57 group group NN cord-010092-uftc8inx 561 58 phenotype phenotype NN cord-010092-uftc8inx 561 59 : : : cord-010092-uftc8inx 562 1 " " `` cord-010092-uftc8inx 562 2 Can Can MD cord-010092-uftc8inx 562 3 you -PRON- PRP cord-010092-uftc8inx 562 4 confirm confirm VB cord-010092-uftc8inx 562 5 my -PRON- PRP$ cord-010092-uftc8inx 562 6 genotype genotype NN cord-010092-uftc8inx 562 7 ? ? . cord-010092-uftc8inx 563 1 " " `` cord-010092-uftc8inx 563 2 3A 3A NNP cord-010092-uftc8inx 563 3 - - HYPH cord-010092-uftc8inx 563 4 S02 S02 NNP cord-010092-uftc8inx 563 5 - - HYPH cord-010092-uftc8inx 563 6 03 03 CD cord-010092-uftc8inx 563 7 Background background NN cord-010092-uftc8inx 563 8 : : : cord-010092-uftc8inx 564 1 The the DT cord-010092-uftc8inx 564 2 screening screening NN cord-010092-uftc8inx 564 3 of of IN cord-010092-uftc8inx 564 4 blood blood NN cord-010092-uftc8inx 564 5 donors donor NNS cord-010092-uftc8inx 564 6 and and CC cord-010092-uftc8inx 564 7 returning return VBG cord-010092-uftc8inx 564 8 travelers traveler NNS cord-010092-uftc8inx 564 9 from from IN cord-010092-uftc8inx 564 10 active active JJ cord-010092-uftc8inx 564 11 transmission transmission NN cord-010092-uftc8inx 564 12 areas area NNS cord-010092-uftc8inx 564 13 have have VBP cord-010092-uftc8inx 564 14 highlighted highlight VBN cord-010092-uftc8inx 564 15 the the DT cord-010092-uftc8inx 564 16 importance importance NN cord-010092-uftc8inx 564 17 of of IN cord-010092-uftc8inx 564 18 diagnosis diagnosis NN cord-010092-uftc8inx 564 19 of of IN cord-010092-uftc8inx 564 20 acute acute JJ cord-010092-uftc8inx 564 21 arboviral arboviral JJ cord-010092-uftc8inx 564 22 infections infection NNS cord-010092-uftc8inx 564 23 . . . cord-010092-uftc8inx 565 1 In in IN cord-010092-uftc8inx 565 2 the the DT cord-010092-uftc8inx 565 3 context context NN cord-010092-uftc8inx 565 4 of of IN cord-010092-uftc8inx 565 5 co co NNS cord-010092-uftc8inx 565 6 - - NNS cord-010092-uftc8inx 565 7 infections infection NNS cord-010092-uftc8inx 565 8 and and CC cord-010092-uftc8inx 565 9 similar similar JJ cord-010092-uftc8inx 565 10 clinical clinical JJ cord-010092-uftc8inx 565 11 signs sign NNS cord-010092-uftc8inx 565 12 in in IN cord-010092-uftc8inx 565 13 endemic endemic JJ cord-010092-uftc8inx 565 14 zones zone NNS cord-010092-uftc8inx 565 15 , , , cord-010092-uftc8inx 565 16 the the DT cord-010092-uftc8inx 565 17 differential differential JJ cord-010092-uftc8inx 565 18 diagnosis diagnosis NN cord-010092-uftc8inx 565 19 of of IN cord-010092-uftc8inx 565 20 arboviruses arboviruses NNP cord-010092-uftc8inx 565 21 is be VBZ cord-010092-uftc8inx 565 22 essential essential JJ cord-010092-uftc8inx 565 23 to to TO cord-010092-uftc8inx 565 24 discriminate discriminate VB cord-010092-uftc8inx 565 25 the the DT cord-010092-uftc8inx 565 26 causative causative JJ cord-010092-uftc8inx 565 27 agent agent NN cord-010092-uftc8inx 565 28 . . . cord-010092-uftc8inx 566 1 The the DT cord-010092-uftc8inx 566 2 detection detection NN cord-010092-uftc8inx 566 3 of of IN cord-010092-uftc8inx 566 4 viral viral JJ cord-010092-uftc8inx 566 5 nucleic nucleic JJ cord-010092-uftc8inx 566 6 acids acid NNS cord-010092-uftc8inx 566 7 in in IN cord-010092-uftc8inx 566 8 serum serum NN cord-010092-uftc8inx 566 9 or or CC cord-010092-uftc8inx 566 10 plasma plasma NN cord-010092-uftc8inx 566 11 provides provide VBZ cord-010092-uftc8inx 566 12 a a DT cord-010092-uftc8inx 566 13 definitive definitive JJ cord-010092-uftc8inx 566 14 diagnosis diagnosis NN cord-010092-uftc8inx 566 15 , , , cord-010092-uftc8inx 566 16 however however RB cord-010092-uftc8inx 566 17 , , , cord-010092-uftc8inx 566 18 in in IN cord-010092-uftc8inx 566 19 most most JJS cord-010092-uftc8inx 566 20 instances instance NNS cord-010092-uftc8inx 566 21 , , , cord-010092-uftc8inx 566 22 viremia viremia NN cord-010092-uftc8inx 566 23 is be VBZ cord-010092-uftc8inx 566 24 transient transient JJ cord-010092-uftc8inx 566 25 within within IN cord-010092-uftc8inx 566 26 less less JJR cord-010092-uftc8inx 566 27 than than IN cord-010092-uftc8inx 566 28 two two CD cord-010092-uftc8inx 566 29 weeks week NNS cord-010092-uftc8inx 566 30 after after IN cord-010092-uftc8inx 566 31 the the DT cord-010092-uftc8inx 566 32 onset onset NN cord-010092-uftc8inx 566 33 of of IN cord-010092-uftc8inx 566 34 clinical clinical JJ cord-010092-uftc8inx 566 35 illness illness NN cord-010092-uftc8inx 566 36 . . . cord-010092-uftc8inx 567 1 In in IN cord-010092-uftc8inx 567 2 addition addition NN cord-010092-uftc8inx 567 3 , , , cord-010092-uftc8inx 567 4 the the DT cord-010092-uftc8inx 567 5 cross cross NN cord-010092-uftc8inx 567 6 reactivity reactivity NN cord-010092-uftc8inx 567 7 due due IN cord-010092-uftc8inx 567 8 to to IN cord-010092-uftc8inx 567 9 the the DT cord-010092-uftc8inx 567 10 high high JJ cord-010092-uftc8inx 567 11 degree degree NN cord-010092-uftc8inx 567 12 of of IN cord-010092-uftc8inx 567 13 structural structural JJ cord-010092-uftc8inx 567 14 and and CC cord-010092-uftc8inx 567 15 sequence sequence NN cord-010092-uftc8inx 567 16 homology homology NN cord-010092-uftc8inx 567 17 between between IN cord-010092-uftc8inx 567 18 ZIKV ZIKV NNP cord-010092-uftc8inx 567 19 and and CC cord-010092-uftc8inx 567 20 other other JJ cord-010092-uftc8inx 567 21 flaviviruses flavivirus NNS cord-010092-uftc8inx 567 22 is be VBZ cord-010092-uftc8inx 567 23 a a DT cord-010092-uftc8inx 567 24 significant significant JJ cord-010092-uftc8inx 567 25 concern concern NN cord-010092-uftc8inx 567 26 . . . cord-010092-uftc8inx 568 1 The the DT cord-010092-uftc8inx 568 2 combination combination NN cord-010092-uftc8inx 568 3 of of IN cord-010092-uftc8inx 568 4 molecular molecular JJ cord-010092-uftc8inx 568 5 ( ( -LRB- cord-010092-uftc8inx 568 6 identification identification NN cord-010092-uftc8inx 568 7 of of IN cord-010092-uftc8inx 568 8 viral viral JJ cord-010092-uftc8inx 568 9 genomes genome NNS cord-010092-uftc8inx 568 10 ) ) -RRB- cord-010092-uftc8inx 568 11 and and CC cord-010092-uftc8inx 568 12 immunological immunological JJ cord-010092-uftc8inx 568 13 assays assay NNS cord-010092-uftc8inx 568 14 ( ( -LRB- cord-010092-uftc8inx 568 15 detection detection NN cord-010092-uftc8inx 568 16 of of IN cord-010092-uftc8inx 568 17 the the DT cord-010092-uftc8inx 568 18 immune immune JJ cord-010092-uftc8inx 568 19 response response NN cord-010092-uftc8inx 568 20 ) ) -RRB- cord-010092-uftc8inx 568 21 is be VBZ cord-010092-uftc8inx 568 22 a a DT cord-010092-uftc8inx 568 23 key key JJ cord-010092-uftc8inx 568 24 challenge challenge NN cord-010092-uftc8inx 568 25 to to TO cord-010092-uftc8inx 568 26 follow follow VB cord-010092-uftc8inx 568 27 the the DT cord-010092-uftc8inx 568 28 natural natural JJ cord-010092-uftc8inx 568 29 history history NN cord-010092-uftc8inx 568 30 of of IN cord-010092-uftc8inx 568 31 these these DT cord-010092-uftc8inx 568 32 infections infection NNS cord-010092-uftc8inx 568 33 and and CC cord-010092-uftc8inx 568 34 to to TO cord-010092-uftc8inx 568 35 improve improve VB cord-010092-uftc8inx 568 36 the the DT cord-010092-uftc8inx 568 37 patient patient NN cord-010092-uftc8inx 568 38 management management NN cord-010092-uftc8inx 568 39 and and CC cord-010092-uftc8inx 568 40 the the DT cord-010092-uftc8inx 568 41 epidemiological epidemiological JJ cord-010092-uftc8inx 568 42 surveillance surveillance NN cord-010092-uftc8inx 568 43 . . . cord-010092-uftc8inx 569 1 Aims aim VBZ cord-010092-uftc8inx 569 2 : : : cord-010092-uftc8inx 570 1 In in IN cord-010092-uftc8inx 570 2 this this DT cord-010092-uftc8inx 570 3 context context NN cord-010092-uftc8inx 570 4 , , , cord-010092-uftc8inx 570 5 we -PRON- PRP cord-010092-uftc8inx 570 6 have have VBP cord-010092-uftc8inx 570 7 developed develop VBN cord-010092-uftc8inx 570 8 an an DT cord-010092-uftc8inx 570 9 innovative innovative JJ cord-010092-uftc8inx 570 10 platform platform NN cord-010092-uftc8inx 570 11 based base VBN cord-010092-uftc8inx 570 12 on on IN cord-010092-uftc8inx 570 13 agglutination agglutination NN cord-010092-uftc8inx 570 14 of of IN cord-010092-uftc8inx 570 15 superparamagnetic superparamagnetic JJ cord-010092-uftc8inx 570 16 nanoparticles nanoparticle NNS cord-010092-uftc8inx 570 17 ( ( -LRB- cord-010092-uftc8inx 570 18 NPMag NPMag NNP cord-010092-uftc8inx 570 19 ) ) -RRB- cord-010092-uftc8inx 570 20 covalently covalently RB cord-010092-uftc8inx 570 21 grafted graft VBN cord-010092-uftc8inx 570 22 either either CC cord-010092-uftc8inx 570 23 with with IN cord-010092-uftc8inx 570 24 nucleic nucleic NNS cord-010092-uftc8inx 570 25 or or CC cord-010092-uftc8inx 570 26 proteic proteic JJ cord-010092-uftc8inx 570 27 probes probe NNS cord-010092-uftc8inx 570 28 to to TO cord-010092-uftc8inx 570 29 face face VB cord-010092-uftc8inx 570 30 the the DT cord-010092-uftc8inx 570 31 continuing continue VBG cord-010092-uftc8inx 570 32 emergence emergence NN cord-010092-uftc8inx 570 33 of of IN cord-010092-uftc8inx 570 34 arboviruses arbovirus NNS cord-010092-uftc8inx 570 35 . . . cord-010092-uftc8inx 571 1 Methods method NNS cord-010092-uftc8inx 571 2 : : : cord-010092-uftc8inx 571 3 Dengue dengue NN cord-010092-uftc8inx 571 4 ( ( -LRB- cord-010092-uftc8inx 571 5 DENV DENV NNP cord-010092-uftc8inx 571 6 ) ) -RRB- cord-010092-uftc8inx 571 7 and and CC cord-010092-uftc8inx 571 8 ZIKA ZIKA NNP cord-010092-uftc8inx 571 9 ( ( -LRB- cord-010092-uftc8inx 571 10 ZIKV ZIKV NNP cord-010092-uftc8inx 571 11 ) ) -RRB- cord-010092-uftc8inx 572 1 viruses virus NNS cord-010092-uftc8inx 572 2 are be VBP cord-010092-uftc8inx 572 3 selected select VBN cord-010092-uftc8inx 572 4 as as IN cord-010092-uftc8inx 572 5 models model NNS cord-010092-uftc8inx 572 6 in in IN cord-010092-uftc8inx 572 7 this this DT cord-010092-uftc8inx 572 8 study study NN cord-010092-uftc8inx 572 9 . . . cord-010092-uftc8inx 573 1 A a DT cord-010092-uftc8inx 573 2 pan pan JJ cord-010092-uftc8inx 573 3 - - JJ cord-010092-uftc8inx 573 4 flavivirus flavivirus JJ cord-010092-uftc8inx 573 5 RT RT NNP cord-010092-uftc8inx 573 6 - - HYPH cord-010092-uftc8inx 573 7 PCR PCR NNP cord-010092-uftc8inx 573 8 is be VBZ cord-010092-uftc8inx 573 9 used use VBN cord-010092-uftc8inx 573 10 for for IN cord-010092-uftc8inx 573 11 the the DT cord-010092-uftc8inx 573 12 molecular molecular JJ cord-010092-uftc8inx 573 13 assay assay NN cord-010092-uftc8inx 573 14 to to TO cord-010092-uftc8inx 573 15 amplify amplify VB cord-010092-uftc8inx 573 16 the the DT cord-010092-uftc8inx 573 17 viral viral JJ cord-010092-uftc8inx 573 18 genomes genome NNS cord-010092-uftc8inx 573 19 . . . cord-010092-uftc8inx 574 1 Then then RB cord-010092-uftc8inx 574 2 , , , cord-010092-uftc8inx 574 3 biotinylated biotinylate VBN cord-010092-uftc8inx 574 4 viral viral JJ cord-010092-uftc8inx 574 5 amplicons amplicon NNS cord-010092-uftc8inx 574 6 are be VBP cord-010092-uftc8inx 574 7 captured capture VBN cord-010092-uftc8inx 574 8 specifically specifically RB cord-010092-uftc8inx 574 9 on on IN cord-010092-uftc8inx 574 10 complementary complementary JJ cord-010092-uftc8inx 574 11 original original JJ cord-010092-uftc8inx 574 12 polythiolated polythiolated JJ cord-010092-uftc8inx 574 13 probes probe NNS cord-010092-uftc8inx 574 14 coated coat VBN cord-010092-uftc8inx 574 15 on on IN cord-010092-uftc8inx 574 16 NPMag NPMag NNP cord-010092-uftc8inx 574 17 . . . cord-010092-uftc8inx 575 1 For for IN cord-010092-uftc8inx 575 2 the the DT cord-010092-uftc8inx 575 3 immunological immunological JJ cord-010092-uftc8inx 575 4 assay assay NN cord-010092-uftc8inx 575 5 , , , cord-010092-uftc8inx 575 6 NPMag NPMag NNP cord-010092-uftc8inx 575 7 are be VBP cord-010092-uftc8inx 575 8 grafted graft VBN cord-010092-uftc8inx 575 9 with with IN cord-010092-uftc8inx 575 10 viral viral JJ cord-010092-uftc8inx 575 11 NS1 ns1 NN cord-010092-uftc8inx 575 12 proteins protein NNS cord-010092-uftc8inx 575 13 to to TO cord-010092-uftc8inx 575 14 capture capture VB cord-010092-uftc8inx 575 15 anti anti JJ cord-010092-uftc8inx 575 16 - - JJ cord-010092-uftc8inx 575 17 DENV denv JJ cord-010092-uftc8inx 575 18 or or CC cord-010092-uftc8inx 575 19 anti anti JJ cord-010092-uftc8inx 575 20 - - JJ cord-010092-uftc8inx 575 21 ZIKV zikv JJ cord-010092-uftc8inx 575 22 antibodies antibody NNS cord-010092-uftc8inx 575 23 potentially potentially RB cord-010092-uftc8inx 575 24 present present JJ cord-010092-uftc8inx 575 25 in in IN cord-010092-uftc8inx 575 26 the the DT cord-010092-uftc8inx 575 27 plasma plasma NN cord-010092-uftc8inx 575 28 samples sample NNS cord-010092-uftc8inx 575 29 . . . cord-010092-uftc8inx 576 1 Both both DT cord-010092-uftc8inx 576 2 tests test NNS cord-010092-uftc8inx 576 3 are be VBP cord-010092-uftc8inx 576 4 performed perform VBN cord-010092-uftc8inx 576 5 in in IN cord-010092-uftc8inx 576 6 disposable disposable JJ cord-010092-uftc8inx 576 7 cuvettes cuvette NNS cord-010092-uftc8inx 576 8 in in IN cord-010092-uftc8inx 576 9 a a DT cord-010092-uftc8inx 576 10 homogeneous homogeneous JJ cord-010092-uftc8inx 576 11 format format NN cord-010092-uftc8inx 576 12 . . . cord-010092-uftc8inx 577 1 A a DT cord-010092-uftc8inx 577 2 magnetic magnetic JJ cord-010092-uftc8inx 577 3 field field NN cord-010092-uftc8inx 577 4 generated generate VBN cord-010092-uftc8inx 577 5 by by IN cord-010092-uftc8inx 577 6 an an DT cord-010092-uftc8inx 577 7 electromagnet electromagnet NN cord-010092-uftc8inx 577 8 is be VBZ cord-010092-uftc8inx 577 9 applied apply VBN cord-010092-uftc8inx 577 10 to to IN cord-010092-uftc8inx 577 11 the the DT cord-010092-uftc8inx 577 12 reaction reaction NN cord-010092-uftc8inx 577 13 medium medium NN cord-010092-uftc8inx 577 14 to to TO cord-010092-uftc8inx 577 15 align align VB cord-010092-uftc8inx 577 16 the the DT cord-010092-uftc8inx 577 17 NPMag NPMag NNP cord-010092-uftc8inx 577 18 into into IN cord-010092-uftc8inx 577 19 chains chain NNS cord-010092-uftc8inx 577 20 to to TO cord-010092-uftc8inx 577 21 enhance enhance VB cord-010092-uftc8inx 577 22 the the DT cord-010092-uftc8inx 577 23 capture capture NN cord-010092-uftc8inx 577 24 of of IN cord-010092-uftc8inx 577 25 the the DT cord-010092-uftc8inx 577 26 targets target NNS cord-010092-uftc8inx 577 27 between between IN cord-010092-uftc8inx 577 28 two two CD cord-010092-uftc8inx 577 29 NPMag NPMag NNS cord-010092-uftc8inx 577 30 . . . cord-010092-uftc8inx 578 1 Aggregates aggregate NNS cord-010092-uftc8inx 578 2 formed form VBN cord-010092-uftc8inx 578 3 are be VBP cord-010092-uftc8inx 578 4 detected detect VBN cord-010092-uftc8inx 578 5 when when WRB cord-010092-uftc8inx 578 6 the the DT cord-010092-uftc8inx 578 7 field field NN cord-010092-uftc8inx 578 8 is be VBZ cord-010092-uftc8inx 578 9 turned turn VBN cord-010092-uftc8inx 578 10 off off RP cord-010092-uftc8inx 578 11 . . . cord-010092-uftc8inx 579 1 The the DT cord-010092-uftc8inx 579 2 optical optical JJ cord-010092-uftc8inx 579 3 density density NN cord-010092-uftc8inx 579 4 is be VBZ cord-010092-uftc8inx 579 5 measured measure VBN cord-010092-uftc8inx 579 6 in in IN cord-010092-uftc8inx 579 7 real real JJ cord-010092-uftc8inx 579 8 - - HYPH cord-010092-uftc8inx 579 9 time time NN cord-010092-uftc8inx 579 10 at at IN cord-010092-uftc8inx 579 11 650 650 CD cord-010092-uftc8inx 579 12 nm nm NN cord-010092-uftc8inx 579 13 during during IN cord-010092-uftc8inx 579 14 several several JJ cord-010092-uftc8inx 579 15 cycles cycle NNS cord-010092-uftc8inx 579 16 of of IN cord-010092-uftc8inx 579 17 magnetization magnetization NN cord-010092-uftc8inx 579 18 / / SYM cord-010092-uftc8inx 579 19 relaxation relaxation NN cord-010092-uftc8inx 579 20 . . . cord-010092-uftc8inx 580 1 Results result NNS cord-010092-uftc8inx 580 2 : : : cord-010092-uftc8inx 581 1 In in IN cord-010092-uftc8inx 581 2 this this DT cord-010092-uftc8inx 581 3 study study NN cord-010092-uftc8inx 581 4 , , , cord-010092-uftc8inx 581 5 molecular molecular JJ cord-010092-uftc8inx 581 6 analytical analytical JJ cord-010092-uftc8inx 581 7 performances performance NNS cord-010092-uftc8inx 581 8 were be VBD cord-010092-uftc8inx 581 9 evaluated evaluate VBN cord-010092-uftc8inx 581 10 on on IN cord-010092-uftc8inx 581 11 human human JJ cord-010092-uftc8inx 581 12 samples sample NNS cord-010092-uftc8inx 581 13 from from IN cord-010092-uftc8inx 581 14 blood blood NN cord-010092-uftc8inx 581 15 donors donor NNS cord-010092-uftc8inx 581 16 with with IN cord-010092-uftc8inx 581 17 no no DT cord-010092-uftc8inx 581 18 history history NN cord-010092-uftc8inx 581 19 of of IN cord-010092-uftc8inx 581 20 infections infection NNS cord-010092-uftc8inx 581 21 as as IN cord-010092-uftc8inx 581 22 negative negative JJ cord-010092-uftc8inx 581 23 controls control NNS cord-010092-uftc8inx 581 24 , , , cord-010092-uftc8inx 581 25 on on IN cord-010092-uftc8inx 581 26 viral viral JJ cord-010092-uftc8inx 581 27 standards standard NNS cord-010092-uftc8inx 581 28 and and CC cord-010092-uftc8inx 581 29 on on IN cord-010092-uftc8inx 581 30 clinical clinical JJ cord-010092-uftc8inx 581 31 samples sample NNS cord-010092-uftc8inx 581 32 . . . cord-010092-uftc8inx 582 1 Using use VBG cord-010092-uftc8inx 582 2 viral viral JJ cord-010092-uftc8inx 582 3 references reference NNS cord-010092-uftc8inx 582 4 standards standard NNS cord-010092-uftc8inx 582 5 , , , cord-010092-uftc8inx 582 6 we -PRON- PRP cord-010092-uftc8inx 582 7 have have VBP cord-010092-uftc8inx 582 8 observed observe VBN cord-010092-uftc8inx 582 9 sensitivities sensitivity NNS cord-010092-uftc8inx 582 10 of of IN cord-010092-uftc8inx 582 11 10 10 CD cord-010092-uftc8inx 582 12 -10 -10 SYM cord-010092-uftc8inx 582 13 2 2 CD cord-010092-uftc8inx 582 14 TCID TCID NNP cord-010092-uftc8inx 582 15 50 50 CD cord-010092-uftc8inx 582 16 /mL /mL : cord-010092-uftc8inx 582 17 for for IN cord-010092-uftc8inx 582 18 ZIKV ZIKV NNP cord-010092-uftc8inx 582 19 and and CC cord-010092-uftc8inx 582 20 DENV DENV NNP cord-010092-uftc8inx 582 21 ( ( -LRB- cord-010092-uftc8inx 582 22 serotypes serotypes NN cord-010092-uftc8inx 582 23 1/2/3/4 1/2/3/4 JJ cord-010092-uftc8inx 582 24 ) ) -RRB- cord-010092-uftc8inx 582 25 after after IN cord-010092-uftc8inx 582 26 a a DT cord-010092-uftc8inx 582 27 detection detection NN cord-010092-uftc8inx 582 28 phase phase NN cord-010092-uftc8inx 582 29 of of IN cord-010092-uftc8inx 582 30 around around RB cord-010092-uftc8inx 582 31 5 5 CD cord-010092-uftc8inx 582 32 min min NN cord-010092-uftc8inx 582 33 . . . cord-010092-uftc8inx 583 1 The the DT cord-010092-uftc8inx 583 2 first first JJ cord-010092-uftc8inx 583 3 results result NNS cord-010092-uftc8inx 583 4 obtained obtain VBN cord-010092-uftc8inx 583 5 on on IN cord-010092-uftc8inx 583 6 16 16 CD cord-010092-uftc8inx 583 7 ZIKV ZIKV NNP cord-010092-uftc8inx 583 8 ( ( -LRB- cord-010092-uftc8inx 583 9 + + CC cord-010092-uftc8inx 583 10 ) ) -RRB- cord-010092-uftc8inx 583 11 clinical clinical JJ cord-010092-uftc8inx 583 12 samples sample NNS cord-010092-uftc8inx 583 13 previously previously RB cord-010092-uftc8inx 583 14 tested test VBN cord-010092-uftc8inx 583 15 by by IN cord-010092-uftc8inx 583 16 commercial commercial JJ cord-010092-uftc8inx 583 17 real real JJ cord-010092-uftc8inx 583 18 - - HYPH cord-010092-uftc8inx 583 19 time time NN cord-010092-uftc8inx 583 20 PCR PCR NNP cord-010092-uftc8inx 583 21 ( ( -LRB- cord-010092-uftc8inx 583 22 Ct Ct NNP cord-010092-uftc8inx 583 23 < < NNP cord-010092-uftc8inx 583 24 36 36 CD cord-010092-uftc8inx 583 25 , , , cord-010092-uftc8inx 583 26 Altona Altona NNP cord-010092-uftc8inx 583 27 ) ) -RRB- cord-010092-uftc8inx 583 28 showed show VBD cord-010092-uftc8inx 583 29 an an DT cord-010092-uftc8inx 583 30 88 88 CD cord-010092-uftc8inx 583 31 % % NN cord-010092-uftc8inx 583 32 correlation correlation NN cord-010092-uftc8inx 583 33 between between IN cord-010092-uftc8inx 583 34 the the DT cord-010092-uftc8inx 583 35 two two CD cord-010092-uftc8inx 583 36 detection detection NN cord-010092-uftc8inx 583 37 methods method NNS cord-010092-uftc8inx 583 38 . . . cord-010092-uftc8inx 584 1 No no DT cord-010092-uftc8inx 584 2 false false JJ cord-010092-uftc8inx 584 3 positive positive JJ cord-010092-uftc8inx 584 4 results result NNS cord-010092-uftc8inx 584 5 or or CC cord-010092-uftc8inx 584 6 cross cross NN cord-010092-uftc8inx 584 7 reactions reaction NNS cord-010092-uftc8inx 584 8 were be VBD cord-010092-uftc8inx 584 9 observed observe VBN cord-010092-uftc8inx 584 10 . . . cord-010092-uftc8inx 585 1 Concerning concern VBG cord-010092-uftc8inx 585 2 immunological immunological JJ cord-010092-uftc8inx 585 3 assays assay NNS cord-010092-uftc8inx 585 4 , , , cord-010092-uftc8inx 585 5 commercial commercial JJ cord-010092-uftc8inx 585 6 human human JJ cord-010092-uftc8inx 585 7 plasma plasma NN cord-010092-uftc8inx 585 8 from from IN cord-010092-uftc8inx 585 9 donors donor NNS cord-010092-uftc8inx 585 10 tested test VBD cord-010092-uftc8inx 585 11 positive positive JJ cord-010092-uftc8inx 585 12 for for IN cord-010092-uftc8inx 585 13 DENV DENV NNP cord-010092-uftc8inx 585 14 or or CC cord-010092-uftc8inx 585 15 ZIKV ZIKV NNP cord-010092-uftc8inx 585 16 antibodies antibody NNS cord-010092-uftc8inx 585 17 were be VBD cord-010092-uftc8inx 585 18 detected detect VBN cord-010092-uftc8inx 585 19 positive positive JJ cord-010092-uftc8inx 585 20 with with IN cord-010092-uftc8inx 585 21 our -PRON- PRP$ cord-010092-uftc8inx 585 22 innovative innovative JJ cord-010092-uftc8inx 585 23 approach approach NN cord-010092-uftc8inx 585 24 in in IN cord-010092-uftc8inx 585 25 less less JJR cord-010092-uftc8inx 585 26 than than IN cord-010092-uftc8inx 585 27 10 10 CD cord-010092-uftc8inx 585 28 min min NN cord-010092-uftc8inx 585 29 ( ( -LRB- cord-010092-uftc8inx 585 30 sampling sampling NN cord-010092-uftc8inx 585 31 + + CC cord-010092-uftc8inx 585 32 detection detection NN cord-010092-uftc8inx 585 33 ) ) -RRB- cord-010092-uftc8inx 585 34 instead instead RB cord-010092-uftc8inx 585 35 of of IN cord-010092-uftc8inx 585 36 2 2 CD cord-010092-uftc8inx 585 37 h h NN cord-010092-uftc8inx 585 38 with with IN cord-010092-uftc8inx 585 39 classical classical JJ cord-010092-uftc8inx 585 40 ELISAs elisa NNS cord-010092-uftc8inx 585 41 . . . cord-010092-uftc8inx 586 1 Further further JJ cord-010092-uftc8inx 586 2 assays assay NNS cord-010092-uftc8inx 586 3 on on IN cord-010092-uftc8inx 586 4 clinical clinical JJ cord-010092-uftc8inx 586 5 samples sample NNS cord-010092-uftc8inx 586 6 are be VBP cord-010092-uftc8inx 586 7 planned plan VBN cord-010092-uftc8inx 586 8 to to TO cord-010092-uftc8inx 586 9 confirm confirm VB cord-010092-uftc8inx 586 10 these these DT cord-010092-uftc8inx 586 11 preliminary preliminary JJ cord-010092-uftc8inx 586 12 results result NNS cord-010092-uftc8inx 586 13 . . . cord-010092-uftc8inx 587 1 Summary Summary NNP cord-010092-uftc8inx 587 2 / / SYM cord-010092-uftc8inx 587 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 587 4 : : : cord-010092-uftc8inx 588 1 This this DT cord-010092-uftc8inx 588 2 innovative innovative JJ cord-010092-uftc8inx 588 3 strategy strategy NN cord-010092-uftc8inx 588 4 combining combine VBG cord-010092-uftc8inx 588 5 molecular molecular JJ cord-010092-uftc8inx 588 6 and and CC cord-010092-uftc8inx 588 7 immunoassays immunoassay NNS cord-010092-uftc8inx 588 8 on on IN cord-010092-uftc8inx 588 9 the the DT cord-010092-uftc8inx 588 10 same same JJ cord-010092-uftc8inx 588 11 analytical analytical JJ cord-010092-uftc8inx 588 12 platform platform NN cord-010092-uftc8inx 588 13 offers offer VBZ cord-010092-uftc8inx 588 14 new new JJ cord-010092-uftc8inx 588 15 opportunities opportunity NNS cord-010092-uftc8inx 588 16 for for IN cord-010092-uftc8inx 588 17 rapid rapid JJ cord-010092-uftc8inx 588 18 blood blood NN cord-010092-uftc8inx 588 19 testing testing NN cord-010092-uftc8inx 588 20 to to TO cord-010092-uftc8inx 588 21 improve improve VB cord-010092-uftc8inx 588 22 the the DT cord-010092-uftc8inx 588 23 surveillance surveillance NN cord-010092-uftc8inx 588 24 and and CC cord-010092-uftc8inx 588 25 the the DT cord-010092-uftc8inx 588 26 prevention prevention NN cord-010092-uftc8inx 588 27 of of IN cord-010092-uftc8inx 588 28 arboviral arboviral NNP cord-010092-uftc8inx 588 29 infections infection NNS cord-010092-uftc8inx 588 30 . . . cord-010092-uftc8inx 589 1 Background background NN cord-010092-uftc8inx 589 2 : : : cord-010092-uftc8inx 590 1 Zika Zika NNP cord-010092-uftc8inx 590 2 virus virus NN cord-010092-uftc8inx 590 3 ( ( -LRB- cord-010092-uftc8inx 590 4 ZIKV ZIKV NNP cord-010092-uftc8inx 590 5 ) ) -RRB- cord-010092-uftc8inx 590 6 caused cause VBD cord-010092-uftc8inx 590 7 a a DT cord-010092-uftc8inx 590 8 dramatic dramatic JJ cord-010092-uftc8inx 590 9 epidemic epidemic NN cord-010092-uftc8inx 590 10 in in IN cord-010092-uftc8inx 590 11 Puerto Puerto NNP cord-010092-uftc8inx 590 12 Rico Rico NNP cord-010092-uftc8inx 590 13 ( ( -LRB- cord-010092-uftc8inx 590 14 PR PR NNP cord-010092-uftc8inx 590 15 ) ) -RRB- cord-010092-uftc8inx 590 16 during during IN cord-010092-uftc8inx 590 17 2016 2016 CD cord-010092-uftc8inx 590 18 , , , cord-010092-uftc8inx 590 19 with with IN cord-010092-uftc8inx 590 20 up up RB cord-010092-uftc8inx 590 21 to~2 to~2 NN cord-010092-uftc8inx 590 22 % % NN cord-010092-uftc8inx 590 23 of of IN cord-010092-uftc8inx 590 24 blood blood NN cord-010092-uftc8inx 590 25 donors donor NNS cord-010092-uftc8inx 590 26 reactive reactive JJ cord-010092-uftc8inx 590 27 for for IN cord-010092-uftc8inx 590 28 ZIKV ZIKV NNP cord-010092-uftc8inx 590 29 RNA RNA NNP cord-010092-uftc8inx 590 30 in in IN cord-010092-uftc8inx 590 31 ID ID NNP cord-010092-uftc8inx 590 32 - - HYPH cord-010092-uftc8inx 590 33 NAT NAT NNP cord-010092-uftc8inx 590 34 testing testing NN cord-010092-uftc8inx 590 35 at at IN cord-010092-uftc8inx 590 36 the the DT cord-010092-uftc8inx 590 37 peak peak NN cord-010092-uftc8inx 590 38 in in IN cord-010092-uftc8inx 590 39 June June NNP cord-010092-uftc8inx 590 40 2016 2016 CD cord-010092-uftc8inx 590 41 . . . cord-010092-uftc8inx 591 1 Aims aim VBZ cord-010092-uftc8inx 591 2 : : : cord-010092-uftc8inx 591 3 Perform perform VB cord-010092-uftc8inx 591 4 a a DT cord-010092-uftc8inx 591 5 serosurvey serosurvey NN cord-010092-uftc8inx 591 6 for for IN cord-010092-uftc8inx 591 7 anti anti JJ cord-010092-uftc8inx 591 8 - - JJ cord-010092-uftc8inx 591 9 ZIKV zikv JJ cord-010092-uftc8inx 591 10 IgG igg NN cord-010092-uftc8inx 591 11 using use VBG cord-010092-uftc8inx 591 12 six six CD cord-010092-uftc8inx 591 13 panels panel NNS cord-010092-uftc8inx 591 14 of of IN cord-010092-uftc8inx 591 15 500 500 CD cord-010092-uftc8inx 591 16 donor donor NN cord-010092-uftc8inx 591 17 specimens specimen NNS cord-010092-uftc8inx 591 18 each each DT cord-010092-uftc8inx 591 19 collected collect VBN cord-010092-uftc8inx 591 20 in in IN cord-010092-uftc8inx 591 21 March March NNP cord-010092-uftc8inx 591 22 2015 2015 CD cord-010092-uftc8inx 591 23 , , , cord-010092-uftc8inx 591 24 at at IN cord-010092-uftc8inx 591 25 the the DT cord-010092-uftc8inx 591 26 beginning beginning NN cord-010092-uftc8inx 591 27 , , , cord-010092-uftc8inx 591 28 peak peak NN cord-010092-uftc8inx 591 29 and and CC cord-010092-uftc8inx 591 30 end end NN cord-010092-uftc8inx 591 31 of of IN cord-010092-uftc8inx 591 32 the the DT cord-010092-uftc8inx 591 33 2016 2016 CD cord-010092-uftc8inx 591 34 epidemic epidemic NN cord-010092-uftc8inx 591 35 , , , cord-010092-uftc8inx 591 36 and and CC cord-010092-uftc8inx 591 37 from from IN cord-010092-uftc8inx 591 38 March March NNP cord-010092-uftc8inx 591 39 2017 2017 CD cord-010092-uftc8inx 591 40 and and CC cord-010092-uftc8inx 591 41 April April NNP cord-010092-uftc8inx 591 42 2018 2018 CD cord-010092-uftc8inx 591 43 . . . cord-010092-uftc8inx 592 1 Methods method NNS cord-010092-uftc8inx 592 2 : : : cord-010092-uftc8inx 592 3 We -PRON- PRP cord-010092-uftc8inx 592 4 employed employ VBD cord-010092-uftc8inx 592 5 a a DT cord-010092-uftc8inx 592 6 commercially commercially RB cord-010092-uftc8inx 592 7 available available JJ cord-010092-uftc8inx 592 8 ZIKV ZIKV NNP cord-010092-uftc8inx 592 9 IgG IgG NNP cord-010092-uftc8inx 592 10 ELISA ELISA NNP cord-010092-uftc8inx 592 11 antibody antibody NN cord-010092-uftc8inx 592 12 ( ( -LRB- cord-010092-uftc8inx 592 13 Ab Ab NNP cord-010092-uftc8inx 592 14 ) ) -RRB- cord-010092-uftc8inx 592 15 assay assay NN cord-010092-uftc8inx 592 16 based base VBN cord-010092-uftc8inx 592 17 on on IN cord-010092-uftc8inx 592 18 the the DT cord-010092-uftc8inx 592 19 ZIKV ZIKV NNP cord-010092-uftc8inx 592 20 NS1 NS1 NNS cord-010092-uftc8inx 592 21 antigen antigen NN cord-010092-uftc8inx 592 22 from from IN cord-010092-uftc8inx 592 23 Bio Bio NNP cord-010092-uftc8inx 592 24 - - HYPH cord-010092-uftc8inx 592 25 Techne Techne NNP cord-010092-uftc8inx 592 26 to to TO cord-010092-uftc8inx 592 27 characterize characterize VB cord-010092-uftc8inx 592 28 ZIKV ZIKV NNP cord-010092-uftc8inx 592 29 seroprevalence seroprevalence NN cord-010092-uftc8inx 592 30 in in IN cord-010092-uftc8inx 592 31 the the DT cord-010092-uftc8inx 592 32 6 6 CD cord-010092-uftc8inx 592 33 9 9 CD cord-010092-uftc8inx 592 34 500 500 CD cord-010092-uftc8inx 592 35 cross cross JJ cord-010092-uftc8inx 592 36 - - JJ cord-010092-uftc8inx 592 37 sectional sectional JJ cord-010092-uftc8inx 592 38 sample sample NN cord-010092-uftc8inx 592 39 sets set NNS cord-010092-uftc8inx 592 40 ( ( -LRB- cord-010092-uftc8inx 592 41 anonymized anonymize VBN cord-010092-uftc8inx 592 42 with with IN cord-010092-uftc8inx 592 43 selected select VBN cord-010092-uftc8inx 592 44 demographic demographic JJ cord-010092-uftc8inx 592 45 information information NN cord-010092-uftc8inx 592 46 ) ) -RRB- cord-010092-uftc8inx 592 47 . . . cord-010092-uftc8inx 593 1 Results result NNS cord-010092-uftc8inx 593 2 : : : cord-010092-uftc8inx 594 1 500 500 CD cord-010092-uftc8inx 594 2 PR pr NN cord-010092-uftc8inx 594 3 donor donor NN cord-010092-uftc8inx 594 4 samples sample NNS cord-010092-uftc8inx 594 5 collected collect VBN cord-010092-uftc8inx 594 6 in in IN cord-010092-uftc8inx 594 7 April April NNP cord-010092-uftc8inx 594 8 2015 2015 CD cord-010092-uftc8inx 594 9 were be VBD cord-010092-uftc8inx 594 10 initially initially RB cord-010092-uftc8inx 594 11 evaluated evaluate VBN cord-010092-uftc8inx 594 12 using use VBG cord-010092-uftc8inx 594 13 the the DT cord-010092-uftc8inx 594 14 manufacturer manufacturer NN cord-010092-uftc8inx 594 15 supplied supply VBD cord-010092-uftc8inx 594 16 cut cut NN cord-010092-uftc8inx 594 17 - - HYPH cord-010092-uftc8inx 594 18 off off NN cord-010092-uftc8inx 594 19 to to TO cord-010092-uftc8inx 594 20 confirm confirm VB cord-010092-uftc8inx 594 21 that that IN cord-010092-uftc8inx 594 22 the the DT cord-010092-uftc8inx 594 23 ZIKV ZIKV NNP cord-010092-uftc8inx 594 24 Ab Ab NNP cord-010092-uftc8inx 594 25 results result NNS cord-010092-uftc8inx 594 26 were be VBD cord-010092-uftc8inx 594 27 largely largely RB cord-010092-uftc8inx 594 28 negative negative JJ cord-010092-uftc8inx 594 29 ( ( -LRB- cord-010092-uftc8inx 594 30 3 3 CD cord-010092-uftc8inx 594 31 positive positive JJ cord-010092-uftc8inx 594 32 , , , cord-010092-uftc8inx 594 33 3 3 CD cord-010092-uftc8inx 594 34 equivocal equivocal JJ cord-010092-uftc8inx 594 35 ) ) -RRB- cord-010092-uftc8inx 594 36 despite despite IN cord-010092-uftc8inx 594 37 the the DT cord-010092-uftc8inx 594 38 high high JJ cord-010092-uftc8inx 594 39 dengue dengue NN cord-010092-uftc8inx 594 40 virus virus NN cord-010092-uftc8inx 594 41 seroprevalence seroprevalence NN cord-010092-uftc8inx 594 42 ( ( -LRB- cord-010092-uftc8inx 594 43 > > NFP cord-010092-uftc8inx 594 44 90 90 CD cord-010092-uftc8inx 594 45 % % NN cord-010092-uftc8inx 594 46 ) ) -RRB- cord-010092-uftc8inx 594 47 in in IN cord-010092-uftc8inx 594 48 PR PR NNP cord-010092-uftc8inx 594 49 that that WDT cord-010092-uftc8inx 594 50 could could MD cord-010092-uftc8inx 594 51 potentially potentially RB cord-010092-uftc8inx 594 52 lead lead VB cord-010092-uftc8inx 594 53 to to IN cord-010092-uftc8inx 594 54 false false JJ cord-010092-uftc8inx 594 55 positive positive JJ cord-010092-uftc8inx 594 56 ZIKV ZIKV NNP cord-010092-uftc8inx 594 57 Ab Ab NNP cord-010092-uftc8inx 594 58 results result NNS cord-010092-uftc8inx 594 59 . . . cord-010092-uftc8inx 595 1 We -PRON- PRP cord-010092-uftc8inx 595 2 then then RB cord-010092-uftc8inx 595 3 used use VBD cord-010092-uftc8inx 595 4 this this DT cord-010092-uftc8inx 595 5 dataset dataset NN cord-010092-uftc8inx 595 6 , , , cord-010092-uftc8inx 595 7 together together RB cord-010092-uftc8inx 595 8 with with IN cord-010092-uftc8inx 595 9 known know VBN cord-010092-uftc8inx 595 10 positives positive NNS cord-010092-uftc8inx 595 11 collected collect VBD cord-010092-uftc8inx 595 12 1 1 CD cord-010092-uftc8inx 595 13 - - SYM cord-010092-uftc8inx 595 14 3 3 CD cord-010092-uftc8inx 595 15 months month NNS cord-010092-uftc8inx 595 16 postdetection postdetection NN cord-010092-uftc8inx 595 17 from from IN cord-010092-uftc8inx 595 18 ZIKV ZIKV NNP cord-010092-uftc8inx 595 19 NAT NAT NNP cord-010092-uftc8inx 595 20 yield yield VBP cord-010092-uftc8inx 595 21 donors donor NNS cord-010092-uftc8inx 595 22 , , , cord-010092-uftc8inx 595 23 to to TO cord-010092-uftc8inx 595 24 set set VB cord-010092-uftc8inx 595 25 a a DT cord-010092-uftc8inx 595 26 population population NN cord-010092-uftc8inx 595 27 - - HYPH cord-010092-uftc8inx 595 28 specific specific JJ cord-010092-uftc8inx 595 29 cut cut VBN cord-010092-uftc8inx 595 30 - - HYPH cord-010092-uftc8inx 595 31 off off RP cord-010092-uftc8inx 595 32 based base VBN cord-010092-uftc8inx 595 33 on on IN cord-010092-uftc8inx 595 34 receiver receiver NN cord-010092-uftc8inx 595 35 operating operating NN cord-010092-uftc8inx 595 36 characteristic characteristic NN cord-010092-uftc8inx 595 37 ( ( -LRB- cord-010092-uftc8inx 595 38 ROC ROC NNP cord-010092-uftc8inx 595 39 ) ) -RRB- cord-010092-uftc8inx 595 40 curve curve NN cord-010092-uftc8inx 595 41 analysis analysis NN cord-010092-uftc8inx 595 42 . . . cord-010092-uftc8inx 596 1 This this DT cord-010092-uftc8inx 596 2 cut cut VB cord-010092-uftc8inx 596 3 - - HYPH cord-010092-uftc8inx 596 4 off off RP cord-010092-uftc8inx 596 5 yielded yielded JJ cord-010092-uftc8inx 596 6 sensitivity sensitivity NN cord-010092-uftc8inx 596 7 and and CC cord-010092-uftc8inx 596 8 specificity specificity NN cord-010092-uftc8inx 596 9 values value NNS cord-010092-uftc8inx 596 10 of of IN cord-010092-uftc8inx 596 11 > > $ cord-010092-uftc8inx 596 12 99 99 CD cord-010092-uftc8inx 596 13 % % NN cord-010092-uftc8inx 596 14 , , , cord-010092-uftc8inx 596 15 and and CC cord-010092-uftc8inx 596 16 an an DT cord-010092-uftc8inx 596 17 area area NN cord-010092-uftc8inx 596 18 under under IN cord-010092-uftc8inx 596 19 the the DT cord-010092-uftc8inx 596 20 curve curve NN cord-010092-uftc8inx 596 21 ( ( -LRB- cord-010092-uftc8inx 596 22 AUC AUC NNP cord-010092-uftc8inx 596 23 ) ) -RRB- cord-010092-uftc8inx 596 24 of of IN cord-010092-uftc8inx 596 25 0.999 0.999 CD cord-010092-uftc8inx 596 26 , , , cord-010092-uftc8inx 596 27 demonstrating demonstrate VBG cord-010092-uftc8inx 596 28 a a DT cord-010092-uftc8inx 596 29 highly highly RB cord-010092-uftc8inx 596 30 accurate accurate JJ cord-010092-uftc8inx 596 31 assay assay NN cord-010092-uftc8inx 596 32 . . . cord-010092-uftc8inx 597 1 We -PRON- PRP cord-010092-uftc8inx 597 2 used use VBD cord-010092-uftc8inx 597 3 this this DT cord-010092-uftc8inx 597 4 new new JJ cord-010092-uftc8inx 597 5 cut cut VBN cord-010092-uftc8inx 597 6 - - HYPH cord-010092-uftc8inx 597 7 off off NN cord-010092-uftc8inx 597 8 to to TO cord-010092-uftc8inx 597 9 calculate calculate VB cord-010092-uftc8inx 597 10 final final JJ cord-010092-uftc8inx 597 11 rates rate NNS cord-010092-uftc8inx 597 12 of of IN cord-010092-uftc8inx 597 13 seroreactivity seroreactivity NN cord-010092-uftc8inx 597 14 in in IN cord-010092-uftc8inx 597 15 the the DT cord-010092-uftc8inx 597 16 additional additional JJ cord-010092-uftc8inx 597 17 5 5 CD cord-010092-uftc8inx 597 18 sample sample NN cord-010092-uftc8inx 597 19 sets set NNS cord-010092-uftc8inx 597 20 ( ( -LRB- cord-010092-uftc8inx 597 21 2500 2500 CD cord-010092-uftc8inx 597 22 samples sample NNS cord-010092-uftc8inx 597 23 ) ) -RRB- cord-010092-uftc8inx 597 24 and and CC cord-010092-uftc8inx 597 25 estimate estimate VB cord-010092-uftc8inx 597 26 seasonal seasonal JJ cord-010092-uftc8inx 597 27 incidence incidence NN cord-010092-uftc8inx 597 28 . . . cord-010092-uftc8inx 598 1 Rates rate NNS cord-010092-uftc8inx 598 2 of of IN cord-010092-uftc8inx 598 3 reactivity reactivity NN cord-010092-uftc8inx 598 4 , , , cord-010092-uftc8inx 598 5 together together RB cord-010092-uftc8inx 598 6 with with IN cord-010092-uftc8inx 598 7 mean mean JJ cord-010092-uftc8inx 598 8 net net JJ cord-010092-uftc8inx 598 9 OD od NN cord-010092-uftc8inx 598 10 for for IN cord-010092-uftc8inx 598 11 only only RB cord-010092-uftc8inx 598 12 the the DT cord-010092-uftc8inx 598 13 reactives reactive NNS cord-010092-uftc8inx 598 14 ( ( -LRB- cord-010092-uftc8inx 598 15 shown show VBN cord-010092-uftc8inx 598 16 in in IN cord-010092-uftc8inx 598 17 parentheses parenthesis NNS cord-010092-uftc8inx 598 18 ) ) -RRB- cord-010092-uftc8inx 598 19 , , , cord-010092-uftc8inx 598 20 were be VBD cord-010092-uftc8inx 598 21 calculated calculate VBN cord-010092-uftc8inx 598 22 for for IN cord-010092-uftc8inx 598 23 each each DT cord-010092-uftc8inx 598 24 sample sample NN cord-010092-uftc8inx 598 25 set set VBN cord-010092-uftc8inx 599 1 : : : cord-010092-uftc8inx 599 2 Background background NN cord-010092-uftc8inx 599 3 : : : cord-010092-uftc8inx 600 1 Sex sex NN cord-010092-uftc8inx 600 2 hormone hormone NN cord-010092-uftc8inx 600 3 intake intake NN cord-010092-uftc8inx 600 4 in in IN cord-010092-uftc8inx 600 5 blood blood NN cord-010092-uftc8inx 600 6 donors donor NNS cord-010092-uftc8inx 600 7 occurs occur VBZ cord-010092-uftc8inx 600 8 in in IN cord-010092-uftc8inx 600 9 three three CD cord-010092-uftc8inx 600 10 demographic demographic JJ cord-010092-uftc8inx 600 11 groups group NNS cord-010092-uftc8inx 600 12 : : : cord-010092-uftc8inx 600 13 premenopausal premenopausal JJ cord-010092-uftc8inx 600 14 women woman NNS cord-010092-uftc8inx 600 15 who who WP cord-010092-uftc8inx 600 16 take take VBP cord-010092-uftc8inx 600 17 contraceptive contraceptive JJ cord-010092-uftc8inx 600 18 drugs drug NNS cord-010092-uftc8inx 600 19 ( ( -LRB- cord-010092-uftc8inx 600 20 progestins progestin NNS cord-010092-uftc8inx 600 21 with with IN cord-010092-uftc8inx 600 22 or or CC cord-010092-uftc8inx 600 23 without without IN cord-010092-uftc8inx 600 24 estrogens estrogen NNS cord-010092-uftc8inx 600 25 ) ) -RRB- cord-010092-uftc8inx 600 26 , , , cord-010092-uftc8inx 600 27 postmenopausal postmenopausal JJ cord-010092-uftc8inx 600 28 women woman NNS cord-010092-uftc8inx 600 29 who who WP cord-010092-uftc8inx 600 30 receive receive VBP cord-010092-uftc8inx 600 31 estrogen estrogen NN cord-010092-uftc8inx 600 32 replacement replacement NN cord-010092-uftc8inx 600 33 therapies therapy NNS cord-010092-uftc8inx 600 34 that that WDT cord-010092-uftc8inx 600 35 may may MD cord-010092-uftc8inx 600 36 be be VB cord-010092-uftc8inx 600 37 combined combine VBN cord-010092-uftc8inx 600 38 with with IN cord-010092-uftc8inx 600 39 progestins progestin NNS cord-010092-uftc8inx 600 40 , , , cord-010092-uftc8inx 600 41 and and CC cord-010092-uftc8inx 600 42 testosterone testosterone NN cord-010092-uftc8inx 600 43 therapies therapy NNS cord-010092-uftc8inx 600 44 in in IN cord-010092-uftc8inx 600 45 men man NNS cord-010092-uftc8inx 600 46 . . . cord-010092-uftc8inx 601 1 We -PRON- PRP cord-010092-uftc8inx 601 2 hypothesized hypothesize VBD cord-010092-uftc8inx 601 3 that that IN cord-010092-uftc8inx 601 4 sex sex NN cord-010092-uftc8inx 601 5 hormone hormone NN cord-010092-uftc8inx 601 6 therapies therapy NNS cord-010092-uftc8inx 601 7 may may MD cord-010092-uftc8inx 601 8 modulate modulate VB cord-010092-uftc8inx 601 9 the the DT cord-010092-uftc8inx 601 10 quality quality NN cord-010092-uftc8inx 601 11 of of IN cord-010092-uftc8inx 601 12 red red JJ cord-010092-uftc8inx 601 13 blood blood NN cord-010092-uftc8inx 601 14 cell cell NN cord-010092-uftc8inx 601 15 ( ( -LRB- cord-010092-uftc8inx 601 16 RBC RBC NNP cord-010092-uftc8inx 601 17 ) ) -RRB- cord-010092-uftc8inx 601 18 products product NNS cord-010092-uftc8inx 601 19 via via IN cord-010092-uftc8inx 601 20 alterations alteration NNS cord-010092-uftc8inx 601 21 of of IN cord-010092-uftc8inx 601 22 RBC RBC NNP cord-010092-uftc8inx 601 23 function function NN cord-010092-uftc8inx 601 24 and and CC cord-010092-uftc8inx 601 25 predisposition predisposition NN cord-010092-uftc8inx 601 26 to to IN cord-010092-uftc8inx 601 27 hemolysis hemolysis NN cord-010092-uftc8inx 601 28 during during IN cord-010092-uftc8inx 601 29 cold cold JJ cord-010092-uftc8inx 601 30 storage storage NN cord-010092-uftc8inx 601 31 . . . cord-010092-uftc8inx 602 1 Aims aim VBZ cord-010092-uftc8inx 602 2 : : : cord-010092-uftc8inx 603 1 The the DT cord-010092-uftc8inx 603 2 objectives objective NNS cord-010092-uftc8inx 603 3 of of IN cord-010092-uftc8inx 603 4 this this DT cord-010092-uftc8inx 603 5 study study NN cord-010092-uftc8inx 603 6 were be VBD cord-010092-uftc8inx 603 7 to to TO cord-010092-uftc8inx 603 8 evaluate evaluate VB cord-010092-uftc8inx 603 9 the the DT cord-010092-uftc8inx 603 10 association association NN cord-010092-uftc8inx 603 11 between between IN cord-010092-uftc8inx 603 12 sex sex NN cord-010092-uftc8inx 603 13 hormone hormone NN cord-010092-uftc8inx 603 14 intake intake NN cord-010092-uftc8inx 603 15 and and CC cord-010092-uftc8inx 603 16 RBC RBC NNP cord-010092-uftc8inx 603 17 measurements measurement NNS cord-010092-uftc8inx 603 18 of of IN cord-010092-uftc8inx 603 19 hemolysis hemolysis NN cord-010092-uftc8inx 603 20 , , , cord-010092-uftc8inx 603 21 and and CC cord-010092-uftc8inx 603 22 to to TO cord-010092-uftc8inx 603 23 examine examine VB cord-010092-uftc8inx 603 24 possible possible JJ cord-010092-uftc8inx 603 25 mechanisms mechanism NNS cord-010092-uftc8inx 603 26 by by IN cord-010092-uftc8inx 603 27 which which WDT cord-010092-uftc8inx 603 28 sex sex NN cord-010092-uftc8inx 603 29 hormones hormone NNS cord-010092-uftc8inx 603 30 interact interact VBP cord-010092-uftc8inx 603 31 with with IN cord-010092-uftc8inx 603 32 RBCs rbc NNS cord-010092-uftc8inx 603 33 . . . cord-010092-uftc8inx 604 1 Methods method NNS cord-010092-uftc8inx 604 2 : : : cord-010092-uftc8inx 605 1 Self self NN cord-010092-uftc8inx 605 2 - - HYPH cord-010092-uftc8inx 605 3 reported report VBN cord-010092-uftc8inx 605 4 sex sex NN cord-010092-uftc8inx 605 5 hormone hormone NN cord-010092-uftc8inx 605 6 intake intake NN cord-010092-uftc8inx 605 7 and and CC cord-010092-uftc8inx 605 8 menstrual menstrual JJ cord-010092-uftc8inx 605 9 status status NN cord-010092-uftc8inx 605 10 were be VBD cord-010092-uftc8inx 605 11 evaluated evaluate VBN cord-010092-uftc8inx 605 12 in in IN cord-010092-uftc8inx 605 13 6,636 6,636 CD cord-010092-uftc8inx 605 14 female female JJ cord-010092-uftc8inx 605 15 blood blood NN cord-010092-uftc8inx 605 16 donors donor NNS cord-010092-uftc8inx 605 17 from from IN cord-010092-uftc8inx 605 18 the the DT cord-010092-uftc8inx 605 19 National National NNP cord-010092-uftc8inx 605 20 Heart Heart NNP cord-010092-uftc8inx 605 21 , , , cord-010092-uftc8inx 605 22 Lung Lung NNP cord-010092-uftc8inx 605 23 and and CC cord-010092-uftc8inx 605 24 Blood Blood NNP cord-010092-uftc8inx 605 25 Institute Institute NNP cord-010092-uftc8inx 605 26 's 's POS cord-010092-uftc8inx 605 27 RBC RBC NNP cord-010092-uftc8inx 605 28 - - HYPH cord-010092-uftc8inx 605 29 Omics Omics NNP cord-010092-uftc8inx 605 30 study study NN cord-010092-uftc8inx 605 31 . . . cord-010092-uftc8inx 606 1 The the DT cord-010092-uftc8inx 606 2 associations association NNS cord-010092-uftc8inx 606 3 between between IN cord-010092-uftc8inx 606 4 hormone hormone NN cord-010092-uftc8inx 606 5 intake intake NN cord-010092-uftc8inx 606 6 and and CC cord-010092-uftc8inx 606 7 donor donor NN cord-010092-uftc8inx 606 8 scores score NNS cord-010092-uftc8inx 606 9 of of IN cord-010092-uftc8inx 606 10 spontaneous spontaneous JJ cord-010092-uftc8inx 606 11 storage storage NN cord-010092-uftc8inx 606 12 , , , cord-010092-uftc8inx 606 13 osmotic osmotic NN cord-010092-uftc8inx 606 14 , , , cord-010092-uftc8inx 606 15 or or CC cord-010092-uftc8inx 606 16 oxidative oxidative JJ cord-010092-uftc8inx 606 17 hemolysis hemolysis NN cord-010092-uftc8inx 606 18 were be VBD cord-010092-uftc8inx 606 19 determined determine VBN cord-010092-uftc8inx 606 20 in in IN cord-010092-uftc8inx 606 21 all all DT cord-010092-uftc8inx 606 22 women woman NNS cord-010092-uftc8inx 606 23 and and CC cord-010092-uftc8inx 606 24 by by IN cord-010092-uftc8inx 606 25 menstrual menstrual JJ cord-010092-uftc8inx 606 26 state state NN cord-010092-uftc8inx 606 27 . . . cord-010092-uftc8inx 607 1 The the DT cord-010092-uftc8inx 607 2 interactions interaction NNS cord-010092-uftc8inx 607 3 between between IN cord-010092-uftc8inx 607 4 sex sex NN cord-010092-uftc8inx 607 5 hormones hormone NNS cord-010092-uftc8inx 607 6 and and CC cord-010092-uftc8inx 607 7 RBCs rbc NNS cord-010092-uftc8inx 607 8 were be VBD cord-010092-uftc8inx 607 9 determined determine VBN cord-010092-uftc8inx 607 10 by by IN cord-010092-uftc8inx 607 11 sex sex NN cord-010092-uftc8inx 607 12 hormone hormone NN cord-010092-uftc8inx 607 13 ( ( -LRB- cord-010092-uftc8inx 607 14 progesterone progesterone NN cord-010092-uftc8inx 607 15 , , , cord-010092-uftc8inx 607 16 17b 17b NN cord-010092-uftc8inx 607 17 - - HYPH cord-010092-uftc8inx 607 18 estradiol estradiol NN cord-010092-uftc8inx 607 19 , , , cord-010092-uftc8inx 607 20 or or CC cord-010092-uftc8inx 607 21 testosterone testosterone NN cord-010092-uftc8inx 607 22 ) ) -RRB- cord-010092-uftc8inx 607 23 potency potency NN cord-010092-uftc8inx 607 24 to to TO cord-010092-uftc8inx 607 25 inhibit inhibit VB cord-010092-uftc8inx 607 26 calcium calcium NN cord-010092-uftc8inx 607 27 influx influx NN cord-010092-uftc8inx 607 28 or or CC cord-010092-uftc8inx 607 29 hemolysis hemolysis NN cord-010092-uftc8inx 607 30 during during IN cord-010092-uftc8inx 607 31 incubations incubation NNS cord-010092-uftc8inx 607 32 or or CC cord-010092-uftc8inx 607 33 cold cold JJ cord-010092-uftc8inx 607 34 storage storage NN cord-010092-uftc8inx 607 35 . . . cord-010092-uftc8inx 608 1 The the DT cord-010092-uftc8inx 608 2 calcium calcium NN cord-010092-uftc8inx 608 3 fluorophore fluorophore NN cord-010092-uftc8inx 608 4 , , , cord-010092-uftc8inx 608 5 Fluo-3AM Fluo-3AM NNP cord-010092-uftc8inx 608 6 , , , cord-010092-uftc8inx 608 7 was be VBD cord-010092-uftc8inx 608 8 used use VBN cord-010092-uftc8inx 608 9 to to TO cord-010092-uftc8inx 608 10 define define VB cord-010092-uftc8inx 608 11 RBC RBC NNP cord-010092-uftc8inx 608 12 calcium calcium NN cord-010092-uftc8inx 608 13 influx influx NN cord-010092-uftc8inx 608 14 in in IN cord-010092-uftc8inx 608 15 response response NN cord-010092-uftc8inx 608 16 to to IN cord-010092-uftc8inx 608 17 treatments treatment NNS cord-010092-uftc8inx 608 18 with with IN cord-010092-uftc8inx 608 19 sex sex NN cord-010092-uftc8inx 608 20 hormones hormone NNS cord-010092-uftc8inx 608 21 or or CC cord-010092-uftc8inx 608 22 drugs drug NNS cord-010092-uftc8inx 608 23 that that WDT cord-010092-uftc8inx 608 24 modulate modulate VBP cord-010092-uftc8inx 608 25 transient transient JJ cord-010092-uftc8inx 608 26 receptor receptor NN cord-010092-uftc8inx 608 27 potential potential JJ cord-010092-uftc8inx 608 28 cation cation NN cord-010092-uftc8inx 608 29 ( ( -LRB- cord-010092-uftc8inx 608 30 TRPC TRPC NNP cord-010092-uftc8inx 608 31 ) ) -RRB- cord-010092-uftc8inx 608 32 channel channel NN cord-010092-uftc8inx 608 33 activity activity NN cord-010092-uftc8inx 608 34 including include VBG cord-010092-uftc8inx 608 35 Hyp9 Hyp9 NNP cord-010092-uftc8inx 608 36 ( ( -LRB- cord-010092-uftc8inx 608 37 a a DT cord-010092-uftc8inx 608 38 selective selective JJ cord-010092-uftc8inx 608 39 TRPC6 TRPC6 NNP cord-010092-uftc8inx 608 40 activator activator NN cord-010092-uftc8inx 608 41 ) ) -RRB- cord-010092-uftc8inx 608 42 . . . cord-010092-uftc8inx 609 1 Results result NNS cord-010092-uftc8inx 609 2 : : : cord-010092-uftc8inx 610 1 Sex sex NN cord-010092-uftc8inx 610 2 hormone hormone NN cord-010092-uftc8inx 610 3 intake intake NN cord-010092-uftc8inx 610 4 by by IN cord-010092-uftc8inx 610 5 menstrual menstrual JJ cord-010092-uftc8inx 610 6 status status NN cord-010092-uftc8inx 610 7 was be VBD cord-010092-uftc8inx 610 8 higher high JJR cord-010092-uftc8inx 610 9 in in IN cord-010092-uftc8inx 610 10 premenopausal premenopausal JJ cord-010092-uftc8inx 610 11 women woman NNS cord-010092-uftc8inx 610 12 ( ( -LRB- cord-010092-uftc8inx 610 13 25.3 25.3 CD cord-010092-uftc8inx 610 14 % % NN cord-010092-uftc8inx 610 15 ) ) -RRB- cord-010092-uftc8inx 610 16 than than IN cord-010092-uftc8inx 610 17 in in IN cord-010092-uftc8inx 610 18 postmenopausal postmenopausal JJ cord-010092-uftc8inx 610 19 women woman NNS cord-010092-uftc8inx 610 20 ( ( -LRB- cord-010092-uftc8inx 610 21 7.4 7.4 CD cord-010092-uftc8inx 610 22 % % NN cord-010092-uftc8inx 610 23 ) ) -RRB- cord-010092-uftc8inx 610 24 . . . cord-010092-uftc8inx 611 1 Female female JJ cord-010092-uftc8inx 611 2 hormone hormone NN cord-010092-uftc8inx 611 3 intake intake NN cord-010092-uftc8inx 611 4 was be VBD cord-010092-uftc8inx 611 5 significantly significantly RB cord-010092-uftc8inx 611 6 ( ( -LRB- cord-010092-uftc8inx 611 7 all all DT cord-010092-uftc8inx 611 8 P p NN cord-010092-uftc8inx 611 9 < < XX cord-010092-uftc8inx 611 10 0.0001 0.0001 CD cord-010092-uftc8inx 611 11 ) ) -RRB- cord-010092-uftc8inx 611 12 associated associate VBN cord-010092-uftc8inx 611 13 with with IN cord-010092-uftc8inx 611 14 reduced reduce VBN cord-010092-uftc8inx 611 15 storage storage NN cord-010092-uftc8inx 611 16 hemolysis hemolysis NN cord-010092-uftc8inx 611 17 in in IN cord-010092-uftc8inx 611 18 all all DT cord-010092-uftc8inx 611 19 females female NNS cord-010092-uftc8inx 611 20 ( ( -LRB- cord-010092-uftc8inx 611 21 0.32 0.32 CD cord-010092-uftc8inx 611 22 AE AE NNP cord-010092-uftc8inx 611 23 0.16 0.16 CD cord-010092-uftc8inx 611 24 % % NN cord-010092-uftc8inx 611 25 versus versus IN cord-010092-uftc8inx 611 26 0.35 0.35 CD cord-010092-uftc8inx 611 27 AE AE NNP cord-010092-uftc8inx 611 28 0.29 0.29 CD cord-010092-uftc8inx 611 29 % % NN cord-010092-uftc8inx 611 30 in in IN cord-010092-uftc8inx 611 31 controls control NNS cord-010092-uftc8inx 611 32 ) ) -RRB- cord-010092-uftc8inx 611 33 , , , cord-010092-uftc8inx 611 34 enhanced enhance VBN cord-010092-uftc8inx 611 35 susceptibility susceptibility NN cord-010092-uftc8inx 611 36 to to IN cord-010092-uftc8inx 611 37 oxidative oxidative JJ cord-010092-uftc8inx 611 38 hemolysis hemolysis NN cord-010092-uftc8inx 611 39 ( ( -LRB- cord-010092-uftc8inx 611 40 37.9 37.9 CD cord-010092-uftc8inx 611 41 AE AE NNP cord-010092-uftc8inx 611 42 9.3 9.3 CD cord-010092-uftc8inx 611 43 % % NN cord-010092-uftc8inx 611 44 versus versus IN cord-010092-uftc8inx 611 45 35.8 35.8 CD cord-010092-uftc8inx 611 46 AE AE NNP cord-010092-uftc8inx 611 47 9.9 9.9 CD cord-010092-uftc8inx 611 48 % % NN cord-010092-uftc8inx 611 49 in in IN cord-010092-uftc8inx 611 50 controls control NNS cord-010092-uftc8inx 611 51 ) ) -RRB- cord-010092-uftc8inx 611 52 , , , cord-010092-uftc8inx 611 53 and and CC cord-010092-uftc8inx 611 54 reduced reduce VBN cord-010092-uftc8inx 611 55 osmotic osmotic JJ cord-010092-uftc8inx 611 56 hemolysis hemolysis NN cord-010092-uftc8inx 611 57 in in IN cord-010092-uftc8inx 611 58 postmenopausal postmenopausal JJ cord-010092-uftc8inx 611 59 women woman NNS cord-010092-uftc8inx 611 60 ( ( -LRB- cord-010092-uftc8inx 611 61 23.1 23.1 CD cord-010092-uftc8inx 611 62 AE AE NNP cord-010092-uftc8inx 611 63 10.2 10.2 CD cord-010092-uftc8inx 611 64 % % NN cord-010092-uftc8inx 611 65 versus versus IN cord-010092-uftc8inx 611 66 26.8 26.8 CD cord-010092-uftc8inx 611 67 AE AE NNP cord-010092-uftc8inx 611 68 12.0 12.0 CD cord-010092-uftc8inx 611 69 % % NN cord-010092-uftc8inx 611 70 in in IN cord-010092-uftc8inx 611 71 controls control NNS cord-010092-uftc8inx 611 72 ) ) -RRB- cord-010092-uftc8inx 611 73 . . . cord-010092-uftc8inx 612 1 In in IN cord-010092-uftc8inx 612 2 vitro vitro FW cord-010092-uftc8inx 612 3 , , , cord-010092-uftc8inx 612 4 supraphysiological supraphysiological JJ cord-010092-uftc8inx 612 5 levels level NNS cord-010092-uftc8inx 612 6 of of IN cord-010092-uftc8inx 612 7 progesterone progesterone NN cord-010092-uftc8inx 612 8 ( ( -LRB- cord-010092-uftc8inx 612 9 10 10 CD cord-010092-uftc8inx 612 10 or or CC cord-010092-uftc8inx 612 11 20 20 CD cord-010092-uftc8inx 612 12 lmol lmol JJ cord-010092-uftc8inx 612 13 / / SYM cord-010092-uftc8inx 612 14 L L NNP cord-010092-uftc8inx 612 15 ) ) -RRB- cord-010092-uftc8inx 612 16 , , , cord-010092-uftc8inx 612 17 but but CC cord-010092-uftc8inx 612 18 not not RB cord-010092-uftc8inx 612 19 17b 17b NN cord-010092-uftc8inx 612 20 - - : cord-010092-uftc8inx 612 21 estradiol estradiol NN cord-010092-uftc8inx 612 22 or or CC cord-010092-uftc8inx 612 23 testosterone testosterone NN cord-010092-uftc8inx 612 24 , , , cord-010092-uftc8inx 612 25 inhibited inhibit VBN cord-010092-uftc8inx 612 26 spontaneous spontaneous JJ cord-010092-uftc8inx 612 27 or or CC cord-010092-uftc8inx 612 28 Hyp9-induced hyp9-induced JJ cord-010092-uftc8inx 612 29 calcium calcium NN cord-010092-uftc8inx 612 30 influx influx NN cord-010092-uftc8inx 612 31 into into IN cord-010092-uftc8inx 612 32 RBCs rbc NNS cord-010092-uftc8inx 612 33 , , , cord-010092-uftc8inx 612 34 and and CC cord-010092-uftc8inx 612 35 were be VBD cord-010092-uftc8inx 612 36 associated associate VBN cord-010092-uftc8inx 612 37 with with IN cord-010092-uftc8inx 612 38 lower low JJR cord-010092-uftc8inx 612 39 spontaneous spontaneous JJ cord-010092-uftc8inx 612 40 hemolysis hemolysis NN cord-010092-uftc8inx 612 41 after after IN cord-010092-uftc8inx 612 42 30 30 CD cord-010092-uftc8inx 612 43 day day NN cord-010092-uftc8inx 612 44 cold cold JJ cord-010092-uftc8inx 612 45 storage storage NN cord-010092-uftc8inx 612 46 ( ( -LRB- cord-010092-uftc8inx 612 47 0.95 0.95 CD cord-010092-uftc8inx 612 48 AE AE NNP cord-010092-uftc8inx 612 49 0.18 0.18 CD cord-010092-uftc8inx 612 50 % % NN cord-010092-uftc8inx 612 51 versus versus IN cord-010092-uftc8inx 612 52 1.85 1.85 CD cord-010092-uftc8inx 612 53 AE AE NNP cord-010092-uftc8inx 612 54 0.35 0.35 CD cord-010092-uftc8inx 612 55 % % NN cord-010092-uftc8inx 612 56 , , , cord-010092-uftc8inx 612 57 progesterone progesterone NN cord-010092-uftc8inx 612 58 10 10 CD cord-010092-uftc8inx 612 59 lmol lmol NNP cord-010092-uftc8inx 612 60 / / SYM cord-010092-uftc8inx 612 61 L l NN cord-010092-uftc8inx 612 62 versus versus IN cord-010092-uftc8inx 612 63 solvent solvent NN cord-010092-uftc8inx 612 64 control control NN cord-010092-uftc8inx 612 65 ( ( -LRB- cord-010092-uftc8inx 612 66 dimethyl dimethyl NN cord-010092-uftc8inx 612 67 sulfoxide sulfoxide NN cord-010092-uftc8inx 612 68 , , , cord-010092-uftc8inx 612 69 0.1 0.1 CD cord-010092-uftc8inx 612 70 % % NN cord-010092-uftc8inx 612 71 ) ) -RRB- cord-010092-uftc8inx 612 72 , , . cord-010092-uftc8inx 613 1 P p NN cord-010092-uftc8inx 613 2 < < XX cord-010092-uftc8inx 613 3 0.0001 0.0001 CD cord-010092-uftc8inx 613 4 ) ) -RRB- cord-010092-uftc8inx 613 5 . . . cord-010092-uftc8inx 614 1 Co Co NNS cord-010092-uftc8inx 614 2 - - NNS cord-010092-uftc8inx 614 3 incubations incubation NNS cord-010092-uftc8inx 614 4 ( ( -LRB- cord-010092-uftc8inx 614 5 2.5 2.5 CD cord-010092-uftc8inx 614 6 h h NN cord-010092-uftc8inx 614 7 , , , cord-010092-uftc8inx 614 8 37 37 CD cord-010092-uftc8inx 614 9 ° ° NN cord-010092-uftc8inx 614 10 C c NN cord-010092-uftc8inx 614 11 ) ) -RRB- cord-010092-uftc8inx 614 12 of of IN cord-010092-uftc8inx 614 13 RBCs rbc NNS cord-010092-uftc8inx 614 14 in in IN cord-010092-uftc8inx 614 15 the the DT cord-010092-uftc8inx 614 16 presence presence NN cord-010092-uftc8inx 614 17 of of IN cord-010092-uftc8inx 614 18 progesterone progesterone NN cord-010092-uftc8inx 614 19 and and CC cord-010092-uftc8inx 614 20 a a DT cord-010092-uftc8inx 614 21 TRPC6 TRPC6 NNP cord-010092-uftc8inx 614 22 activator activator NN cord-010092-uftc8inx 614 23 ( ( -LRB- cord-010092-uftc8inx 614 24 Hyp9 Hyp9 NNP cord-010092-uftc8inx 614 25 , , , cord-010092-uftc8inx 614 26 25 25 CD cord-010092-uftc8inx 614 27 lmol lmol JJ cord-010092-uftc8inx 614 28 / / SYM cord-010092-uftc8inx 614 29 L L NNP cord-010092-uftc8inx 614 30 ) ) -RRB- cord-010092-uftc8inx 614 31 suggested suggest VBD cord-010092-uftc8inx 614 32 that that IN cord-010092-uftc8inx 614 33 progesterone progesterone NN cord-010092-uftc8inx 614 34 protected protect VBD cord-010092-uftc8inx 614 35 against against IN cord-010092-uftc8inx 614 36 Hyp9-induced hyp9-induced JJ cord-010092-uftc8inx 614 37 hemolysis hemolysis NN cord-010092-uftc8inx 614 38 ( ( -LRB- cord-010092-uftc8inx 614 39 1.45 1.45 CD cord-010092-uftc8inx 614 40 AE AE NNP cord-010092-uftc8inx 614 41 0.13 0.13 CD cord-010092-uftc8inx 614 42 % % NN cord-010092-uftc8inx 614 43 and and CC cord-010092-uftc8inx 614 44 1.01 1.01 CD cord-010092-uftc8inx 614 45 AE AE NNP cord-010092-uftc8inx 614 46 0.09 0.09 CD cord-010092-uftc8inx 614 47 % % NN cord-010092-uftc8inx 614 48 versus versus IN cord-010092-uftc8inx 614 49 2.63 2.63 CD cord-010092-uftc8inx 614 50 AE AE NNP cord-010092-uftc8inx 614 51 0.19 0.19 CD cord-010092-uftc8inx 614 52 % % NN cord-010092-uftc8inx 614 53 ; ; : cord-010092-uftc8inx 614 54 Hyp9 Hyp9 NNP cord-010092-uftc8inx 614 55 + + CC cord-010092-uftc8inx 614 56 progesterone progesterone NN cord-010092-uftc8inx 614 57 at at IN cord-010092-uftc8inx 614 58 10 10 CD cord-010092-uftc8inx 614 59 or or CC cord-010092-uftc8inx 614 60 20 20 CD cord-010092-uftc8inx 614 61 lmol lmol JJ cord-010092-uftc8inx 614 62 / / SYM cord-010092-uftc8inx 614 63 L l NN cord-010092-uftc8inx 614 64 versus versus IN cord-010092-uftc8inx 614 65 Hyp9 Hyp9 NNP cord-010092-uftc8inx 614 66 alone alone RB cord-010092-uftc8inx 614 67 , , , cord-010092-uftc8inx 614 68 P p NN cord-010092-uftc8inx 614 69 < < XX cord-010092-uftc8inx 614 70 0.05 0.05 CD cord-010092-uftc8inx 614 71 by by IN cord-010092-uftc8inx 614 72 one one CD cord-010092-uftc8inx 614 73 - - HYPH cord-010092-uftc8inx 614 74 way way NN cord-010092-uftc8inx 614 75 ANOVA ANOVA NNP cord-010092-uftc8inx 614 76 ) ) -RRB- cord-010092-uftc8inx 614 77 . . . cord-010092-uftc8inx 615 1 Summary Summary NNP cord-010092-uftc8inx 615 2 / / SYM cord-010092-uftc8inx 615 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 615 4 : : : cord-010092-uftc8inx 616 1 This this DT cord-010092-uftc8inx 616 2 study study NN cord-010092-uftc8inx 616 3 revealed reveal VBD cord-010092-uftc8inx 616 4 that that IN cord-010092-uftc8inx 616 5 sex sex NN cord-010092-uftc8inx 616 6 hormone hormone NN cord-010092-uftc8inx 616 7 intake intake NN cord-010092-uftc8inx 616 8 in in IN cord-010092-uftc8inx 616 9 blood blood NN cord-010092-uftc8inx 616 10 donors donor NNS cord-010092-uftc8inx 616 11 is be VBZ cord-010092-uftc8inx 616 12 capable capable JJ cord-010092-uftc8inx 616 13 of of IN cord-010092-uftc8inx 616 14 modulating modulate VBG cord-010092-uftc8inx 616 15 RBC RBC NNP cord-010092-uftc8inx 616 16 predisposition predisposition NN cord-010092-uftc8inx 616 17 to to IN cord-010092-uftc8inx 616 18 hemolysis hemolysis NN cord-010092-uftc8inx 616 19 and and CC cord-010092-uftc8inx 616 20 led lead VBD cord-010092-uftc8inx 616 21 us -PRON- PRP cord-010092-uftc8inx 616 22 to to TO cord-010092-uftc8inx 616 23 propose propose VB cord-010092-uftc8inx 616 24 new new JJ cord-010092-uftc8inx 616 25 mechanistic mechanistic JJ cord-010092-uftc8inx 616 26 pathways pathway NNS cord-010092-uftc8inx 616 27 by by IN cord-010092-uftc8inx 616 28 which which WDT cord-010092-uftc8inx 616 29 progesterone progesterone NN cord-010092-uftc8inx 616 30 regulates regulate VBZ cord-010092-uftc8inx 616 31 calcium calcium NN cord-010092-uftc8inx 616 32 influx influx NN cord-010092-uftc8inx 616 33 and and CC cord-010092-uftc8inx 616 34 hemolysis hemolysis NN cord-010092-uftc8inx 616 35 in in IN cord-010092-uftc8inx 616 36 human human JJ cord-010092-uftc8inx 616 37 RBCs rbc NNS cord-010092-uftc8inx 616 38 . . . cord-010092-uftc8inx 617 1 Pre pre JJ cord-010092-uftc8inx 617 2 - - JJ cord-010092-uftc8inx 617 3 and and CC cord-010092-uftc8inx 617 4 postmenopausal postmenopausal JJ cord-010092-uftc8inx 617 5 women woman NNS cord-010092-uftc8inx 617 6 respond respond VBP cord-010092-uftc8inx 617 7 differently differently RB cord-010092-uftc8inx 617 8 to to IN cord-010092-uftc8inx 617 9 hormone hormone NN cord-010092-uftc8inx 617 10 intake intake NN cord-010092-uftc8inx 617 11 and and CC cord-010092-uftc8inx 617 12 its -PRON- PRP$ cord-010092-uftc8inx 617 13 effects effect NNS cord-010092-uftc8inx 617 14 on on IN cord-010092-uftc8inx 617 15 RBC RBC NNP cord-010092-uftc8inx 617 16 responses response NNS cord-010092-uftc8inx 617 17 to to IN cord-010092-uftc8inx 617 18 osmotic osmotic JJ cord-010092-uftc8inx 617 19 or or CC cord-010092-uftc8inx 617 20 oxidative oxidative JJ cord-010092-uftc8inx 617 21 stress stress NN cord-010092-uftc8inx 617 22 . . . cord-010092-uftc8inx 618 1 Progesterone progesterone NN cord-010092-uftc8inx 618 2 modulates modulate VBZ cord-010092-uftc8inx 618 3 calcium calcium NN cord-010092-uftc8inx 618 4 influx influx NN cord-010092-uftc8inx 618 5 into into IN cord-010092-uftc8inx 618 6 RBCs rbc NNS cord-010092-uftc8inx 618 7 via via IN cord-010092-uftc8inx 618 8 a a DT cord-010092-uftc8inx 618 9 mechanism mechanism NN cord-010092-uftc8inx 618 10 that that WDT cord-010092-uftc8inx 618 11 may may MD cord-010092-uftc8inx 618 12 involve involve VB cord-010092-uftc8inx 618 13 interactions interaction NNS cord-010092-uftc8inx 618 14 with with IN cord-010092-uftc8inx 618 15 membrane membrane NN cord-010092-uftc8inx 618 16 TRPC6 TRPC6 NNP cord-010092-uftc8inx 618 17 channels channel NNS cord-010092-uftc8inx 618 18 , , , cord-010092-uftc8inx 618 19 activation activation NN cord-010092-uftc8inx 618 20 of of IN cord-010092-uftc8inx 618 21 which which WDT cord-010092-uftc8inx 618 22 is be VBZ cord-010092-uftc8inx 618 23 associated associate VBN cord-010092-uftc8inx 618 24 with with IN cord-010092-uftc8inx 618 25 pre pre JJ cord-010092-uftc8inx 618 26 - - JJ cord-010092-uftc8inx 618 27 hemolytic hemolytic JJ cord-010092-uftc8inx 618 28 events event NNS cord-010092-uftc8inx 618 29 such such JJ cord-010092-uftc8inx 618 30 as as IN cord-010092-uftc8inx 618 31 senescence senescence NN cord-010092-uftc8inx 618 32 and and CC cord-010092-uftc8inx 618 33 eryptosis eryptosis NN cord-010092-uftc8inx 618 34 . . . cord-010092-uftc8inx 619 1 3A 3a LS cord-010092-uftc8inx 619 2 - - : cord-010092-uftc8inx 619 3 S05 S05 NNP cord-010092-uftc8inx 619 4 - - HYPH cord-010092-uftc8inx 619 5 01 01 CD cord-010092-uftc8inx 620 1 International International NNP cord-010092-uftc8inx 620 2 Cooperation Cooperation NNP cord-010092-uftc8inx 620 3 , , , cord-010092-uftc8inx 620 4 Swiss Swiss NNP cord-010092-uftc8inx 620 5 Red Red NNP cord-010092-uftc8inx 620 6 Cross Cross NNP cord-010092-uftc8inx 620 7 , , , cord-010092-uftc8inx 620 8 Wabern Wabern NNP cord-010092-uftc8inx 620 9 , , , cord-010092-uftc8inx 620 10 Switzerland Switzerland NNP cord-010092-uftc8inx 620 11 Background Background NNP cord-010092-uftc8inx 620 12 : : : cord-010092-uftc8inx 620 13 Red Red NNP cord-010092-uftc8inx 620 14 Cross Cross NNP cord-010092-uftc8inx 620 15 and and CC cord-010092-uftc8inx 620 16 Red Red NNP cord-010092-uftc8inx 620 17 Crescent Crescent NNP cord-010092-uftc8inx 620 18 Societies Societies NNPS cord-010092-uftc8inx 620 19 were be VBD cord-010092-uftc8inx 620 20 playing play VBG cord-010092-uftc8inx 620 21 an an DT cord-010092-uftc8inx 620 22 important important JJ cord-010092-uftc8inx 620 23 role role NN cord-010092-uftc8inx 620 24 in in IN cord-010092-uftc8inx 620 25 setting set VBG cord-010092-uftc8inx 620 26 up up RP cord-010092-uftc8inx 620 27 blood blood NN cord-010092-uftc8inx 620 28 transfusion transfusion NN cord-010092-uftc8inx 620 29 establishments establishment NNS cord-010092-uftc8inx 620 30 in in IN cord-010092-uftc8inx 620 31 many many JJ cord-010092-uftc8inx 620 32 low low JJ cord-010092-uftc8inx 620 33 resource resource NN cord-010092-uftc8inx 620 34 countries country NNS cord-010092-uftc8inx 620 35 . . . cord-010092-uftc8inx 621 1 By by IN cord-010092-uftc8inx 621 2 the the DT cord-010092-uftc8inx 621 3 mid-1970s mid-1970 NNS cord-010092-uftc8inx 621 4 , , , cord-010092-uftc8inx 621 5 the the DT cord-010092-uftc8inx 621 6 Red Red NNP cord-010092-uftc8inx 621 7 Cross Cross NNP cord-010092-uftc8inx 621 8 was be VBD cord-010092-uftc8inx 621 9 active active JJ cord-010092-uftc8inx 621 10 in in IN cord-010092-uftc8inx 621 11 the the DT cord-010092-uftc8inx 621 12 national national JJ cord-010092-uftc8inx 621 13 blood blood NN cord-010092-uftc8inx 621 14 programs program NNS cord-010092-uftc8inx 621 15 in in IN cord-010092-uftc8inx 621 16 approximately approximately RB cord-010092-uftc8inx 621 17 95 95 CD cord-010092-uftc8inx 621 18 % % NN cord-010092-uftc8inx 621 19 of of IN cord-010092-uftc8inx 621 20 countriesmostly countriesmostly RB cord-010092-uftc8inx 621 21 in in IN cord-010092-uftc8inx 621 22 blood blood NN cord-010092-uftc8inx 621 23 donor donor NN cord-010092-uftc8inx 621 24 recruitment recruitment NN cord-010092-uftc8inx 621 25 and and CC cord-010092-uftc8inx 621 26 education education NN cord-010092-uftc8inx 621 27 . . . cord-010092-uftc8inx 622 1 Today today NN cord-010092-uftc8inx 622 2 , , , cord-010092-uftc8inx 622 3 major major JJ cord-010092-uftc8inx 622 4 organizational organizational JJ cord-010092-uftc8inx 622 5 developments development NNS cord-010092-uftc8inx 622 6 in in IN cord-010092-uftc8inx 622 7 blood blood NN cord-010092-uftc8inx 622 8 transfusion transfusion NN cord-010092-uftc8inx 622 9 services service NNS cord-010092-uftc8inx 622 10 were be VBD cord-010092-uftc8inx 622 11 made make VBN cord-010092-uftc8inx 622 12 in in IN cord-010092-uftc8inx 622 13 high high JJ cord-010092-uftc8inx 622 14 income income NN cord-010092-uftc8inx 622 15 settings setting NNS cord-010092-uftc8inx 622 16 , , , cord-010092-uftc8inx 622 17 where where WRB cord-010092-uftc8inx 622 18 nearly nearly RB cord-010092-uftc8inx 622 19 50 50 CD cord-010092-uftc8inx 622 20 % % NN cord-010092-uftc8inx 622 21 of of IN cord-010092-uftc8inx 622 22 all all DT cord-010092-uftc8inx 622 23 worldwide worldwide JJ cord-010092-uftc8inx 622 24 donations donation NNS cord-010092-uftc8inx 622 25 take take VBP cord-010092-uftc8inx 622 26 place place NN cord-010092-uftc8inx 622 27 ( ( -LRB- cord-010092-uftc8inx 622 28 home home NN cord-010092-uftc8inx 622 29 to to IN cord-010092-uftc8inx 622 30 only only RB cord-010092-uftc8inx 622 31 17 17 CD cord-010092-uftc8inx 622 32 % % NN cord-010092-uftc8inx 622 33 of of IN cord-010092-uftc8inx 622 34 the the DT cord-010092-uftc8inx 622 35 population population NN cord-010092-uftc8inx 622 36 ) ) -RRB- cord-010092-uftc8inx 622 37 . . . cord-010092-uftc8inx 623 1 WHO who WP cord-010092-uftc8inx 623 2 data datum NNS cord-010092-uftc8inx 623 3 shows show VBZ cord-010092-uftc8inx 623 4 that that IN cord-010092-uftc8inx 623 5 the the DT cord-010092-uftc8inx 623 6 median median JJ cord-010092-uftc8inx 623 7 annual annual JJ cord-010092-uftc8inx 623 8 blood blood NN cord-010092-uftc8inx 623 9 donation donation NN cord-010092-uftc8inx 623 10 rate rate NN cord-010092-uftc8inx 623 11 in in IN cord-010092-uftc8inx 623 12 high high JJ cord-010092-uftc8inx 623 13 - - HYPH cord-010092-uftc8inx 623 14 income income NN cord-010092-uftc8inx 623 15 countries country NNS cord-010092-uftc8inx 623 16 is be VBZ cord-010092-uftc8inx 623 17 3.21 3.21 CD cord-010092-uftc8inx 623 18 % % NN cord-010092-uftc8inx 623 19 of of IN cord-010092-uftc8inx 623 20 the the DT cord-010092-uftc8inx 623 21 population population NN cord-010092-uftc8inx 623 22 compared compare VBN cord-010092-uftc8inx 623 23 to to IN cord-010092-uftc8inx 623 24 0.46 0.46 CD cord-010092-uftc8inx 623 25 % % NN cord-010092-uftc8inx 623 26 in in IN cord-010092-uftc8inx 623 27 low low JJ cord-010092-uftc8inx 623 28 - - HYPH cord-010092-uftc8inx 623 29 income income NN cord-010092-uftc8inx 623 30 countries country NNS cord-010092-uftc8inx 623 31 . . . cord-010092-uftc8inx 624 1 The the DT cord-010092-uftc8inx 624 2 factors factor NNS cord-010092-uftc8inx 624 3 for for IN cord-010092-uftc8inx 624 4 this this DT cord-010092-uftc8inx 624 5 low low JJ cord-010092-uftc8inx 624 6 turnout turnout NN cord-010092-uftc8inx 624 7 are be VBP cord-010092-uftc8inx 624 8 multilayered multilayered JJ cord-010092-uftc8inx 624 9 , , , cord-010092-uftc8inx 624 10 but but CC cord-010092-uftc8inx 624 11 it -PRON- PRP cord-010092-uftc8inx 624 12 is be VBZ cord-010092-uftc8inx 624 13 well well RB cord-010092-uftc8inx 624 14 - - HYPH cord-010092-uftc8inx 624 15 known know VBN cord-010092-uftc8inx 624 16 that that IN cord-010092-uftc8inx 624 17 most most JJS cord-010092-uftc8inx 624 18 resource resource NN cord-010092-uftc8inx 624 19 poor poor JJ cord-010092-uftc8inx 624 20 settings setting NNS cord-010092-uftc8inx 624 21 suffer suffer VBP cord-010092-uftc8inx 624 22 from from IN cord-010092-uftc8inx 624 23 a a DT cord-010092-uftc8inx 624 24 low low JJ cord-010092-uftc8inx 624 25 rate rate NN cord-010092-uftc8inx 624 26 of of IN cord-010092-uftc8inx 624 27 regular regular JJ cord-010092-uftc8inx 624 28 donors donor NNS cord-010092-uftc8inx 624 29 and and CC cord-010092-uftc8inx 624 30 challenges challenge NNS cord-010092-uftc8inx 624 31 to to TO cord-010092-uftc8inx 624 32 set set VB cord-010092-uftc8inx 624 33 - - HYPH cord-010092-uftc8inx 624 34 up up NN cord-010092-uftc8inx 624 35 and and CC cord-010092-uftc8inx 624 36 financially financially RB cord-010092-uftc8inx 624 37 sustain sustain VB cord-010092-uftc8inx 624 38 a a DT cord-010092-uftc8inx 624 39 national national JJ cord-010092-uftc8inx 624 40 blood blood NN cord-010092-uftc8inx 624 41 donor donor NN cord-010092-uftc8inx 624 42 program program NN cord-010092-uftc8inx 624 43 . . . cord-010092-uftc8inx 625 1 The the DT cord-010092-uftc8inx 625 2 Red Red NNP cord-010092-uftc8inx 625 3 Cross Cross NNP cord-010092-uftc8inx 625 4 and and CC cord-010092-uftc8inx 625 5 Red Red NNP cord-010092-uftc8inx 625 6 Crescent Crescent NNP cord-010092-uftc8inx 625 7 ( ( -LRB- cord-010092-uftc8inx 625 8 RC RC NNP cord-010092-uftc8inx 625 9 ) ) -RRB- cord-010092-uftc8inx 625 10 Societies society NNS cord-010092-uftc8inx 625 11 assume assume VBP cord-010092-uftc8inx 625 12 a a DT cord-010092-uftc8inx 625 13 key key JJ cord-010092-uftc8inx 625 14 role role NN cord-010092-uftc8inx 625 15 by by IN cord-010092-uftc8inx 625 16 reaching reach VBG cord-010092-uftc8inx 625 17 and and CC cord-010092-uftc8inx 625 18 retaining retain VBG cord-010092-uftc8inx 625 19 donors donor NNS cord-010092-uftc8inx 625 20 from from IN cord-010092-uftc8inx 625 21 the the DT cord-010092-uftc8inx 625 22 communities community NNS cord-010092-uftc8inx 625 23 and and CC cord-010092-uftc8inx 625 24 contribute contribute VBP cord-010092-uftc8inx 625 25 significantly significantly RB cord-010092-uftc8inx 625 26 to to IN cord-010092-uftc8inx 625 27 better well JJR cord-010092-uftc8inx 625 28 safety safety NN cord-010092-uftc8inx 625 29 and and CC cord-010092-uftc8inx 625 30 availability availability NN cord-010092-uftc8inx 625 31 of of IN cord-010092-uftc8inx 625 32 blood blood NN cord-010092-uftc8inx 625 33 . . . cord-010092-uftc8inx 626 1 Partnerships partnership NNS cord-010092-uftc8inx 626 2 and and CC cord-010092-uftc8inx 626 3 international international JJ cord-010092-uftc8inx 626 4 collaboration collaboration NN cord-010092-uftc8inx 626 5 , , , cord-010092-uftc8inx 626 6 such such JJ cord-010092-uftc8inx 626 7 as as IN cord-010092-uftc8inx 626 8 the the DT cord-010092-uftc8inx 626 9 Swiss Swiss NNP cord-010092-uftc8inx 626 10 Red Red NNP cord-010092-uftc8inx 626 11 Cross Cross NNP cord-010092-uftc8inx 626 12 ( ( -LRB- cord-010092-uftc8inx 626 13 SRC SRC NNP cord-010092-uftc8inx 626 14 ) ) -RRB- cord-010092-uftc8inx 626 15 program program NN cord-010092-uftc8inx 626 16 , , , cord-010092-uftc8inx 626 17 are be VBP cord-010092-uftc8inx 626 18 aiming aim VBG cord-010092-uftc8inx 626 19 to to TO cord-010092-uftc8inx 626 20 strengthen strengthen VB cord-010092-uftc8inx 626 21 national national JJ cord-010092-uftc8inx 626 22 structures structure NNS cord-010092-uftc8inx 626 23 to to TO cord-010092-uftc8inx 626 24 improve improve VB cord-010092-uftc8inx 626 25 blood blood NN cord-010092-uftc8inx 626 26 safety safety NN cord-010092-uftc8inx 626 27 and and CC cord-010092-uftc8inx 626 28 to to TO cord-010092-uftc8inx 626 29 face face VB cord-010092-uftc8inx 626 30 today today NN cord-010092-uftc8inx 626 31 's 's POS cord-010092-uftc8inx 626 32 epidemiological epidemiological JJ cord-010092-uftc8inx 626 33 , , , cord-010092-uftc8inx 626 34 demographical demographical JJ cord-010092-uftc8inx 626 35 , , , cord-010092-uftc8inx 626 36 and and CC cord-010092-uftc8inx 626 37 technological technological JJ cord-010092-uftc8inx 626 38 challenges challenge NNS cord-010092-uftc8inx 626 39 . . . cord-010092-uftc8inx 627 1 Aims aim VBZ cord-010092-uftc8inx 627 2 : : : cord-010092-uftc8inx 628 1 The the DT cord-010092-uftc8inx 628 2 present present JJ cord-010092-uftc8inx 628 3 work work NN cord-010092-uftc8inx 628 4 aims aim VBZ cord-010092-uftc8inx 628 5 to to TO cord-010092-uftc8inx 628 6 review review VB cord-010092-uftc8inx 628 7 the the DT cord-010092-uftc8inx 628 8 role role NN cord-010092-uftc8inx 628 9 , , , cord-010092-uftc8inx 628 10 the the DT cord-010092-uftc8inx 628 11 mandate mandate NN cord-010092-uftc8inx 628 12 and and CC cord-010092-uftc8inx 628 13 the the DT cord-010092-uftc8inx 628 14 impact impact NN cord-010092-uftc8inx 628 15 of of IN cord-010092-uftc8inx 628 16 RC RC NNP cord-010092-uftc8inx 628 17 Societies Societies NNPS cord-010092-uftc8inx 628 18 in in IN cord-010092-uftc8inx 628 19 improving improve VBG cord-010092-uftc8inx 628 20 blood blood NN cord-010092-uftc8inx 628 21 safety safety NN cord-010092-uftc8inx 628 22 through through IN cord-010092-uftc8inx 628 23 systematic systematic JJ cord-010092-uftc8inx 628 24 " " `` cord-010092-uftc8inx 628 25 Voluntary Voluntary NNP cord-010092-uftc8inx 628 26 Non Non NNP cord-010092-uftc8inx 628 27 - - JJ cord-010092-uftc8inx 628 28 Remunerated remunerated JJ cord-010092-uftc8inx 628 29 Regular Regular NNP cord-010092-uftc8inx 628 30 Blood Blood NNP cord-010092-uftc8inx 628 31 Donor Donor NNP cord-010092-uftc8inx 628 32 " " '' cord-010092-uftc8inx 628 33 ( ( -LRB- cord-010092-uftc8inx 628 34 VNRBD VNRBD NNP cord-010092-uftc8inx 628 35 ) ) -RRB- cord-010092-uftc8inx 628 36 programming programming NN cord-010092-uftc8inx 628 37 and and CC cord-010092-uftc8inx 628 38 international international JJ cord-010092-uftc8inx 628 39 partnerships partnership NNS cord-010092-uftc8inx 628 40 . . . cord-010092-uftc8inx 629 1 Methods method NNS cord-010092-uftc8inx 629 2 : : : cord-010092-uftc8inx 630 1 Data datum NNS cord-010092-uftc8inx 630 2 and and CC cord-010092-uftc8inx 630 3 evidence evidence NN cord-010092-uftc8inx 630 4 is be VBZ cord-010092-uftc8inx 630 5 drawn draw VBN cord-010092-uftc8inx 630 6 from from IN cord-010092-uftc8inx 630 7 the the DT cord-010092-uftc8inx 630 8 SRC SRC NNP cord-010092-uftc8inx 630 9 International International NNP cord-010092-uftc8inx 630 10 Cooperation Cooperation NNP cord-010092-uftc8inx 630 11 projects project NNS cord-010092-uftc8inx 630 12 over over IN cord-010092-uftc8inx 630 13 the the DT cord-010092-uftc8inx 630 14 last last JJ cord-010092-uftc8inx 630 15 30 30 CD cord-010092-uftc8inx 630 16 years year NNS cord-010092-uftc8inx 630 17 , , , cord-010092-uftc8inx 630 18 more more RBR cord-010092-uftc8inx 630 19 specifically specifically RB cord-010092-uftc8inx 630 20 partnering partner VBG cord-010092-uftc8inx 630 21 with with IN cord-010092-uftc8inx 630 22 three three CD cord-010092-uftc8inx 630 23 RC RC NNP cord-010092-uftc8inx 630 24 Societies Societies NNPS cord-010092-uftc8inx 630 25 , , , cord-010092-uftc8inx 630 26 and and CC cord-010092-uftc8inx 630 27 the the DT cord-010092-uftc8inx 630 28 data datum NNS cord-010092-uftc8inx 630 29 from from IN cord-010092-uftc8inx 630 30 the the DT cord-010092-uftc8inx 630 31 Global Global NNP cord-010092-uftc8inx 630 32 Advisory Advisory NNP cord-010092-uftc8inx 630 33 Panel Panel NNP cord-010092-uftc8inx 630 34 ( ( -LRB- cord-010092-uftc8inx 630 35 GAP GAP NNP cord-010092-uftc8inx 630 36 ) ) -RRB- cord-010092-uftc8inx 630 37 of of IN cord-010092-uftc8inx 630 38 the the DT cord-010092-uftc8inx 630 39 IFRC IFRC NNP cord-010092-uftc8inx 630 40 including include VBG cord-010092-uftc8inx 630 41 their -PRON- PRP$ cord-010092-uftc8inx 630 42 2018 2018 CD cord-010092-uftc8inx 630 43 Global Global NNP cord-010092-uftc8inx 630 44 Mapping Mapping NNP cord-010092-uftc8inx 630 45 . . . cord-010092-uftc8inx 631 1 Results result NNS cord-010092-uftc8inx 631 2 : : : cord-010092-uftc8inx 632 1 The the DT cord-010092-uftc8inx 632 2 promotion promotion NN cord-010092-uftc8inx 632 3 of of IN cord-010092-uftc8inx 632 4 VNRBD VNRBD NNP cord-010092-uftc8inx 632 5 has have VBZ cord-010092-uftc8inx 632 6 been be VBN cord-010092-uftc8inx 632 7 a a DT cord-010092-uftc8inx 632 8 specific specific JJ cord-010092-uftc8inx 632 9 objective objective NN cord-010092-uftc8inx 632 10 in in IN cord-010092-uftc8inx 632 11 all all DT cord-010092-uftc8inx 632 12 SRC SRC NNP cord-010092-uftc8inx 632 13 supported support VBD cord-010092-uftc8inx 632 14 programs program NNS cord-010092-uftc8inx 632 15 . . . cord-010092-uftc8inx 633 1 Through through IN cord-010092-uftc8inx 633 2 the the DT cord-010092-uftc8inx 633 3 engagement engagement NN cord-010092-uftc8inx 633 4 of of IN cord-010092-uftc8inx 633 5 the the DT cord-010092-uftc8inx 633 6 RC RC NNP cord-010092-uftc8inx 633 7 Society Society NNP cord-010092-uftc8inx 633 8 , , , cord-010092-uftc8inx 633 9 the the DT cord-010092-uftc8inx 633 10 training training NN cord-010092-uftc8inx 633 11 of of IN cord-010092-uftc8inx 633 12 volunteers volunteer NNS cord-010092-uftc8inx 633 13 and and CC cord-010092-uftc8inx 633 14 partnering partner VBG cord-010092-uftc8inx 633 15 with with IN cord-010092-uftc8inx 633 16 the the DT cord-010092-uftc8inx 633 17 health health NN cord-010092-uftc8inx 633 18 authorities authority NNS cord-010092-uftc8inx 633 19 , , , cord-010092-uftc8inx 633 20 the the DT cord-010092-uftc8inx 633 21 projects project NNS cord-010092-uftc8inx 633 22 significantly significantly RB cord-010092-uftc8inx 633 23 increased increase VBD cord-010092-uftc8inx 633 24 the the DT cord-010092-uftc8inx 633 25 blood blood NN cord-010092-uftc8inx 633 26 donor donor NN cord-010092-uftc8inx 633 27 rate rate NN cord-010092-uftc8inx 633 28 by by IN cord-010092-uftc8inx 633 29 recruiting recruit VBG cord-010092-uftc8inx 633 30 and and CC cord-010092-uftc8inx 633 31 retaining retain VBG cord-010092-uftc8inx 633 32 donors donor NNS cord-010092-uftc8inx 633 33 from from IN cord-010092-uftc8inx 633 34 the the DT cord-010092-uftc8inx 633 35 communities community NNS cord-010092-uftc8inx 633 36 . . . cord-010092-uftc8inx 634 1 For for IN cord-010092-uftc8inx 634 2 example example NN cord-010092-uftc8inx 634 3 , , , cord-010092-uftc8inx 634 4 the the DT cord-010092-uftc8inx 634 5 RC RC NNP cord-010092-uftc8inx 634 6 Societies Societies NNPS cord-010092-uftc8inx 634 7 increased increase VBD cord-010092-uftc8inx 634 8 total total JJ cord-010092-uftc8inx 634 9 donations donation NNS cord-010092-uftc8inx 634 10 by by IN cord-010092-uftc8inx 634 11 25 25 CD cord-010092-uftc8inx 634 12 % % NN cord-010092-uftc8inx 634 13 in in IN cord-010092-uftc8inx 634 14 Lebanon Lebanon NNP cord-010092-uftc8inx 634 15 ; ; : cord-010092-uftc8inx 634 16 VNRBDs vnrbd NNS cord-010092-uftc8inx 634 17 by by IN cord-010092-uftc8inx 634 18 71 71 CD cord-010092-uftc8inx 634 19 % % NN cord-010092-uftc8inx 634 20 annually annually RB cord-010092-uftc8inx 634 21 in in IN cord-010092-uftc8inx 634 22 Kirgizstan Kirgizstan NNP cord-010092-uftc8inx 634 23 , , , cord-010092-uftc8inx 634 24 and and CC cord-010092-uftc8inx 634 25 from from IN cord-010092-uftc8inx 634 26 practically practically RB cord-010092-uftc8inx 634 27 zero zero CD cord-010092-uftc8inx 634 28 to to IN cord-010092-uftc8inx 634 29 3'588 3'588 CD cord-010092-uftc8inx 634 30 in in IN cord-010092-uftc8inx 634 31 South South NNP cord-010092-uftc8inx 634 32 Sudan Sudan NNP cord-010092-uftc8inx 634 33 . . . cord-010092-uftc8inx 635 1 The the DT cord-010092-uftc8inx 635 2 importance importance NN cord-010092-uftc8inx 635 3 of of IN cord-010092-uftc8inx 635 4 RC RC NNP cord-010092-uftc8inx 635 5 Societies Societies NNPS cord-010092-uftc8inx 635 6 was be VBD cord-010092-uftc8inx 635 7 also also RB cord-010092-uftc8inx 635 8 underlined underline VBN cord-010092-uftc8inx 635 9 in in IN cord-010092-uftc8inx 635 10 the the DT cord-010092-uftc8inx 635 11 2018 2018 CD cord-010092-uftc8inx 635 12 published publish VBN cord-010092-uftc8inx 635 13 global global JJ cord-010092-uftc8inx 635 14 mapping mapping NN cord-010092-uftc8inx 635 15 of of IN cord-010092-uftc8inx 635 16 GAP gap NN cord-010092-uftc8inx 635 17 , , , cord-010092-uftc8inx 635 18 which which WDT cord-010092-uftc8inx 635 19 showed show VBD cord-010092-uftc8inx 635 20 that that IN cord-010092-uftc8inx 635 21 36 36 CD cord-010092-uftc8inx 635 22 ( ( -LRB- cord-010092-uftc8inx 635 23 19 19 CD cord-010092-uftc8inx 635 24 % % NN cord-010092-uftc8inx 635 25 ) ) -RRB- cord-010092-uftc8inx 635 26 of of IN cord-010092-uftc8inx 635 27 them -PRON- PRP cord-010092-uftc8inx 635 28 provide provide VBP cord-010092-uftc8inx 635 29 level level NN cord-010092-uftc8inx 635 30 A a NN cord-010092-uftc8inx 635 31 ( ( -LRB- cord-010092-uftc8inx 635 32 Full Full NNP cord-010092-uftc8inx 635 33 Blood Blood NNP cord-010092-uftc8inx 635 34 Service Service NNP cord-010092-uftc8inx 635 35 ) ) -RRB- cord-010092-uftc8inx 635 36 , , , cord-010092-uftc8inx 635 37 75 75 CD cord-010092-uftc8inx 635 38 ( ( -LRB- cord-010092-uftc8inx 635 39 39 39 CD cord-010092-uftc8inx 635 40 % % NN cord-010092-uftc8inx 635 41 ) ) -RRB- cord-010092-uftc8inx 635 42 are be VBP cord-010092-uftc8inx 635 43 Level level NN cord-010092-uftc8inx 635 44 B B NNP cord-010092-uftc8inx 635 45 ( ( -LRB- cord-010092-uftc8inx 635 46 Systematic Systematic NNP cord-010092-uftc8inx 635 47 Blood Blood NNP cord-010092-uftc8inx 635 48 Donor Donor NNP cord-010092-uftc8inx 635 49 Recruitment Recruitment NNP cord-010092-uftc8inx 635 50 ) ) -RRB- cord-010092-uftc8inx 635 51 and and CC cord-010092-uftc8inx 635 52 47 47 CD cord-010092-uftc8inx 635 53 ( ( -LRB- cord-010092-uftc8inx 635 54 25 25 CD cord-010092-uftc8inx 635 55 % % NN cord-010092-uftc8inx 635 56 ) ) -RRB- cord-010092-uftc8inx 635 57 are be VBP cord-010092-uftc8inx 635 58 level level NN cord-010092-uftc8inx 635 59 C c NN cord-010092-uftc8inx 635 60 ( ( -LRB- cord-010092-uftc8inx 635 61 VNRBD VNRBD NNP cord-010092-uftc8inx 635 62 Blood Blood NNP cord-010092-uftc8inx 635 63 Promotion Promotion NNP cord-010092-uftc8inx 635 64 ) ) -RRB- cord-010092-uftc8inx 635 65 blood blood NN cord-010092-uftc8inx 635 66 services service NNS cord-010092-uftc8inx 635 67 . . . cord-010092-uftc8inx 636 1 GAP gap NN cord-010092-uftc8inx 636 2 has have VBZ cord-010092-uftc8inx 636 3 also also RB cord-010092-uftc8inx 636 4 commenced commence VBN cord-010092-uftc8inx 636 5 a a DT cord-010092-uftc8inx 636 6 new new JJ cord-010092-uftc8inx 636 7 three three CD cord-010092-uftc8inx 636 8 year year NN cord-010092-uftc8inx 636 9 VNRBD VNRBD NNP cord-010092-uftc8inx 636 10 support support NN cord-010092-uftc8inx 636 11 program program NN cord-010092-uftc8inx 636 12 aimed aim VBN cord-010092-uftc8inx 636 13 at at IN cord-010092-uftc8inx 636 14 establishing establish VBG cord-010092-uftc8inx 636 15 tools tool NNS cord-010092-uftc8inx 636 16 and and CC cord-010092-uftc8inx 636 17 materials material NNS cord-010092-uftc8inx 636 18 for for IN cord-010092-uftc8inx 636 19 National National NNP cord-010092-uftc8inx 636 20 Societies Societies NNPS cord-010092-uftc8inx 636 21 . . . cord-010092-uftc8inx 637 1 Summary summary NN cord-010092-uftc8inx 637 2 / / SYM cord-010092-uftc8inx 637 3 conclusions conclusion NNS cord-010092-uftc8inx 637 4 : : : cord-010092-uftc8inx 638 1 The the DT cord-010092-uftc8inx 638 2 Red Red NNP cord-010092-uftc8inx 638 3 Cross Cross NNP cord-010092-uftc8inx 638 4 / / SYM cord-010092-uftc8inx 638 5 Red Red NNP cord-010092-uftc8inx 638 6 Crescent Crescent NNP cord-010092-uftc8inx 638 7 Movement Movement NNP cord-010092-uftc8inx 638 8 has have VBZ cord-010092-uftc8inx 638 9 a a DT cord-010092-uftc8inx 638 10 unique unique JJ cord-010092-uftc8inx 638 11 mandate mandate NN cord-010092-uftc8inx 638 12 and and CC cord-010092-uftc8inx 638 13 position position NN cord-010092-uftc8inx 638 14 in in IN cord-010092-uftc8inx 638 15 improving improve VBG cord-010092-uftc8inx 638 16 global global JJ cord-010092-uftc8inx 638 17 blood blood NN cord-010092-uftc8inx 638 18 safety safety NN cord-010092-uftc8inx 638 19 at at IN cord-010092-uftc8inx 638 20 all all DT cord-010092-uftc8inx 638 21 levels level NNS cord-010092-uftc8inx 638 22 ; ; : cord-010092-uftc8inx 638 23 with with IN cord-010092-uftc8inx 638 24 its -PRON- PRP$ cord-010092-uftc8inx 638 25 huge huge JJ cord-010092-uftc8inx 638 26 network network NN cord-010092-uftc8inx 638 27 of of IN cord-010092-uftc8inx 638 28 volunteers volunteer NNS cord-010092-uftc8inx 638 29 , , , cord-010092-uftc8inx 638 30 even even RB cord-010092-uftc8inx 638 31 blood blood NN cord-010092-uftc8inx 638 32 donors donor NNS cord-010092-uftc8inx 638 33 in in IN cord-010092-uftc8inx 638 34 remote remote JJ cord-010092-uftc8inx 638 35 communities community NNS cord-010092-uftc8inx 638 36 can can MD cord-010092-uftc8inx 638 37 be be VB cord-010092-uftc8inx 638 38 reached reach VBN cord-010092-uftc8inx 638 39 and and CC cord-010092-uftc8inx 638 40 retained retain VBN cord-010092-uftc8inx 638 41 . . . cord-010092-uftc8inx 639 1 RC RC NNP cord-010092-uftc8inx 639 2 Societies society NNS cord-010092-uftc8inx 639 3 in in IN cord-010092-uftc8inx 639 4 low low JJ cord-010092-uftc8inx 639 5 resource resource NN cord-010092-uftc8inx 639 6 settings setting NNS cord-010092-uftc8inx 639 7 with with IN cord-010092-uftc8inx 639 8 a a DT cord-010092-uftc8inx 639 9 Level level NN cord-010092-uftc8inx 639 10 B b NN cord-010092-uftc8inx 639 11 or or CC cord-010092-uftc8inx 639 12 Level Level NNP cord-010092-uftc8inx 639 13 C C NNP cord-010092-uftc8inx 639 14 role role NN cord-010092-uftc8inx 639 15 should should MD cord-010092-uftc8inx 639 16 further further RB cord-010092-uftc8inx 639 17 capitalize capitalize VB cord-010092-uftc8inx 639 18 on on IN cord-010092-uftc8inx 639 19 partnerships partnership NNS cord-010092-uftc8inx 639 20 with with IN cord-010092-uftc8inx 639 21 local local JJ cord-010092-uftc8inx 639 22 and and CC cord-010092-uftc8inx 639 23 international international JJ cord-010092-uftc8inx 639 24 actors actor NNS cord-010092-uftc8inx 639 25 to to TO cord-010092-uftc8inx 639 26 leverage leverage VB cord-010092-uftc8inx 639 27 technical technical JJ cord-010092-uftc8inx 639 28 assistance assistance NN cord-010092-uftc8inx 639 29 and and CC cord-010092-uftc8inx 639 30 funding funding NN cord-010092-uftc8inx 639 31 for for IN cord-010092-uftc8inx 639 32 their -PRON- PRP$ cord-010092-uftc8inx 639 33 activities activity NNS cord-010092-uftc8inx 639 34 . . . cord-010092-uftc8inx 640 1 Background background NN cord-010092-uftc8inx 640 2 : : : cord-010092-uftc8inx 641 1 It -PRON- PRP cord-010092-uftc8inx 641 2 is be VBZ cord-010092-uftc8inx 641 3 essential essential JJ cord-010092-uftc8inx 641 4 to to TO cord-010092-uftc8inx 641 5 motivate motivate VB cord-010092-uftc8inx 641 6 and and CC cord-010092-uftc8inx 641 7 encourage encourage VB cord-010092-uftc8inx 641 8 the the DT cord-010092-uftc8inx 641 9 public public NN cord-010092-uftc8inx 641 10 to to TO cord-010092-uftc8inx 641 11 donate donate VB cord-010092-uftc8inx 641 12 blood blood NN cord-010092-uftc8inx 641 13 and and CC cord-010092-uftc8inx 641 14 be be VB cord-010092-uftc8inx 641 15 eager eager JJ cord-010092-uftc8inx 641 16 to to TO cord-010092-uftc8inx 641 17 help help VB cord-010092-uftc8inx 641 18 saving save VBG cord-010092-uftc8inx 641 19 lives life NNS cord-010092-uftc8inx 641 20 , , , cord-010092-uftc8inx 641 21 in in IN cord-010092-uftc8inx 641 22 order order NN cord-010092-uftc8inx 641 23 to to TO cord-010092-uftc8inx 641 24 maintain maintain VB cord-010092-uftc8inx 641 25 safe safe JJ cord-010092-uftc8inx 641 26 and and CC cord-010092-uftc8inx 641 27 adequate adequate JJ cord-010092-uftc8inx 641 28 national national JJ cord-010092-uftc8inx 641 29 blood blood NN cord-010092-uftc8inx 641 30 supply supply NN cord-010092-uftc8inx 641 31 . . . cord-010092-uftc8inx 642 1 Aims aim VBZ cord-010092-uftc8inx 642 2 : : : cord-010092-uftc8inx 642 3 " " `` cord-010092-uftc8inx 642 4 Technical Technical NNP cord-010092-uftc8inx 642 5 Assistance Assistance NNP cord-010092-uftc8inx 642 6 for for IN cord-010092-uftc8inx 642 7 Recruitment Recruitment NNP cord-010092-uftc8inx 642 8 of of IN cord-010092-uftc8inx 642 9 Future Future NNP cord-010092-uftc8inx 642 10 Blood Blood NNP cord-010092-uftc8inx 642 11 Donors Donors NNPS cord-010092-uftc8inx 642 12 ( ( -LRB- cord-010092-uftc8inx 642 13 EuropeAid/ EuropeAid/ NNP cord-010092-uftc8inx 642 14 132420 132420 CD cord-010092-uftc8inx 642 15 / / SYM cord-010092-uftc8inx 642 16 D D NNP cord-010092-uftc8inx 642 17 / / SYM cord-010092-uftc8inx 642 18 SER SER NNP cord-010092-uftc8inx 642 19 / / SYM cord-010092-uftc8inx 642 20 TR tr NN cord-010092-uftc8inx 642 21 ) ) -RRB- cord-010092-uftc8inx 642 22 " " '' cord-010092-uftc8inx 642 23 project project NN cord-010092-uftc8inx 642 24 aimed aim VBN cord-010092-uftc8inx 642 25 to to TO cord-010092-uftc8inx 642 26 avoid avoid VB cord-010092-uftc8inx 642 27 problems problem NNS cord-010092-uftc8inx 642 28 in in IN cord-010092-uftc8inx 642 29 supplying supply VBG cord-010092-uftc8inx 642 30 the the DT cord-010092-uftc8inx 642 31 safest safe JJS cord-010092-uftc8inx 642 32 blood blood NN cord-010092-uftc8inx 642 33 to to TO cord-010092-uftc8inx 642 34 contribute contribute VB cord-010092-uftc8inx 642 35 to to IN cord-010092-uftc8inx 642 36 the the DT cord-010092-uftc8inx 642 37 improvement improvement NN cord-010092-uftc8inx 642 38 of of IN cord-010092-uftc8inx 642 39 public public JJ cord-010092-uftc8inx 642 40 health health NN cord-010092-uftc8inx 642 41 by by IN cord-010092-uftc8inx 642 42 ( ( -LRB- cord-010092-uftc8inx 642 43 i i NN cord-010092-uftc8inx 642 44 ) ) -RRB- cord-010092-uftc8inx 642 45 increasing increase VBG cord-010092-uftc8inx 642 46 the the DT cord-010092-uftc8inx 642 47 knowledge knowledge NN cord-010092-uftc8inx 642 48 of of IN cord-010092-uftc8inx 642 49 primary primary JJ cord-010092-uftc8inx 642 50 and and CC cord-010092-uftc8inx 642 51 secondary secondary JJ cord-010092-uftc8inx 642 52 school school NN cord-010092-uftc8inx 642 53 students student NNS cord-010092-uftc8inx 642 54 regarding regard VBG cord-010092-uftc8inx 642 55 blood blood NN cord-010092-uftc8inx 642 56 donation donation NN cord-010092-uftc8inx 642 57 , , , cord-010092-uftc8inx 642 58 ( ( -LRB- cord-010092-uftc8inx 642 59 ii ii NN cord-010092-uftc8inx 642 60 ) ) -RRB- cord-010092-uftc8inx 642 61 creating create VBG cord-010092-uftc8inx 642 62 sensitivity sensitivity NN cord-010092-uftc8inx 642 63 in in IN cord-010092-uftc8inx 642 64 school school NN cord-010092-uftc8inx 642 65 principals principal NNS cord-010092-uftc8inx 642 66 and and CC cord-010092-uftc8inx 642 67 teachers teacher NNS cord-010092-uftc8inx 642 68 regarding regard VBG cord-010092-uftc8inx 642 69 voluntary voluntary JJ cord-010092-uftc8inx 642 70 non non JJ cord-010092-uftc8inx 642 71 - - JJ cord-010092-uftc8inx 642 72 remunerated remunerated JJ cord-010092-uftc8inx 642 73 blood blood NN cord-010092-uftc8inx 642 74 donation donation NN cord-010092-uftc8inx 642 75 ( ( -LRB- cord-010092-uftc8inx 642 76 VNRD VNRD NNP cord-010092-uftc8inx 642 77 ) ) -RRB- cord-010092-uftc8inx 642 78 , , , cord-010092-uftc8inx 642 79 ( ( -LRB- cord-010092-uftc8inx 642 80 iii iii NN cord-010092-uftc8inx 642 81 ) ) -RRB- cord-010092-uftc8inx 643 1 motivating motivate VBG cord-010092-uftc8inx 643 2 family family NN cord-010092-uftc8inx 643 3 members member NNS cord-010092-uftc8inx 643 4 of of IN cord-010092-uftc8inx 643 5 the the DT cord-010092-uftc8inx 643 6 students student NNS cord-010092-uftc8inx 643 7 for for IN cord-010092-uftc8inx 643 8 blood blood NN cord-010092-uftc8inx 643 9 donation donation NN cord-010092-uftc8inx 643 10 and and CC cord-010092-uftc8inx 643 11 ( ( -LRB- cord-010092-uftc8inx 643 12 iv iv LS cord-010092-uftc8inx 643 13 ) ) -RRB- cord-010092-uftc8inx 643 14 creating create VBG cord-010092-uftc8inx 643 15 public public JJ cord-010092-uftc8inx 643 16 awareness awareness NN cord-010092-uftc8inx 643 17 through through IN cord-010092-uftc8inx 643 18 media medium NNS cord-010092-uftc8inx 643 19 . . . cord-010092-uftc8inx 644 1 Methods method NNS cord-010092-uftc8inx 644 2 : : : cord-010092-uftc8inx 645 1 An an DT cord-010092-uftc8inx 645 2 effective effective JJ cord-010092-uftc8inx 645 3 coordination coordination NN cord-010092-uftc8inx 645 4 is be VBZ cord-010092-uftc8inx 645 5 established establish VBN cord-010092-uftc8inx 645 6 between between IN cord-010092-uftc8inx 645 7 Ministry Ministry NNP cord-010092-uftc8inx 645 8 of of IN cord-010092-uftc8inx 645 9 Health Health NNP cord-010092-uftc8inx 645 10 ( ( -LRB- cord-010092-uftc8inx 645 11 MoH MoH NNP cord-010092-uftc8inx 645 12 ) ) -RRB- cord-010092-uftc8inx 645 13 , , , cord-010092-uftc8inx 645 14 Ministry Ministry NNP cord-010092-uftc8inx 645 15 of of IN cord-010092-uftc8inx 645 16 National National NNP cord-010092-uftc8inx 645 17 Education Education NNP cord-010092-uftc8inx 645 18 ( ( -LRB- cord-010092-uftc8inx 645 19 MoNE MoNE NNP cord-010092-uftc8inx 645 20 ) ) -RRB- cord-010092-uftc8inx 645 21 and and CC cord-010092-uftc8inx 645 22 Turkish turkish JJ cord-010092-uftc8inx 645 23 Red Red NNP cord-010092-uftc8inx 645 24 Crescent Crescent NNP cord-010092-uftc8inx 645 25 ( ( -LRB- cord-010092-uftc8inx 645 26 TRC TRC NNP cord-010092-uftc8inx 645 27 ) ) -RRB- cord-010092-uftc8inx 645 28 . . . cord-010092-uftc8inx 646 1 The the DT cord-010092-uftc8inx 646 2 existing exist VBG cord-010092-uftc8inx 646 3 curricula curriculum NNS cord-010092-uftc8inx 646 4 and and CC cord-010092-uftc8inx 646 5 textbooks textbook NNS cord-010092-uftc8inx 646 6 of of IN cord-010092-uftc8inx 646 7 primary primary JJ cord-010092-uftc8inx 646 8 and and CC cord-010092-uftc8inx 646 9 secondary secondary JJ cord-010092-uftc8inx 646 10 schools school NNS cord-010092-uftc8inx 646 11 were be VBD cord-010092-uftc8inx 646 12 reviewed review VBN cord-010092-uftc8inx 646 13 and and CC cord-010092-uftc8inx 646 14 revised revise VBN cord-010092-uftc8inx 646 15 , , , cord-010092-uftc8inx 646 16 and and CC cord-010092-uftc8inx 646 17 corresponding correspond VBG cord-010092-uftc8inx 646 18 materials material NNS cord-010092-uftc8inx 646 19 on on IN cord-010092-uftc8inx 646 20 the the DT cord-010092-uftc8inx 646 21 importance importance NN cord-010092-uftc8inx 646 22 of of IN cord-010092-uftc8inx 646 23 blood blood NN cord-010092-uftc8inx 646 24 donation donation NN cord-010092-uftc8inx 646 25 were be VBD cord-010092-uftc8inx 646 26 created create VBN cord-010092-uftc8inx 646 27 . . . cord-010092-uftc8inx 647 1 The the DT cord-010092-uftc8inx 647 2 human human JJ cord-010092-uftc8inx 647 3 resources resource NNS cord-010092-uftc8inx 647 4 capacity capacity NN cord-010092-uftc8inx 647 5 of of IN cord-010092-uftc8inx 647 6 MoH MoH NNP cord-010092-uftc8inx 647 7 , , , cord-010092-uftc8inx 647 8 MoNE MoNE NNP cord-010092-uftc8inx 647 9 and and CC cord-010092-uftc8inx 647 10 TRC TRC NNP cord-010092-uftc8inx 647 11 to to TO cord-010092-uftc8inx 647 12 support support VB cord-010092-uftc8inx 647 13 raising raise VBG cord-010092-uftc8inx 647 14 awareness awareness NN cord-010092-uftc8inx 647 15 on on IN cord-010092-uftc8inx 647 16 blood blood NN cord-010092-uftc8inx 647 17 donation donation NN cord-010092-uftc8inx 647 18 were be VBD cord-010092-uftc8inx 647 19 developed develop VBN cord-010092-uftc8inx 647 20 . . . cord-010092-uftc8inx 648 1 To to TO cord-010092-uftc8inx 648 2 raise raise VB cord-010092-uftc8inx 648 3 public public JJ cord-010092-uftc8inx 648 4 awareness awareness NN cord-010092-uftc8inx 648 5 on on IN cord-010092-uftc8inx 648 6 blood blood NN cord-010092-uftc8inx 648 7 donation donation NN cord-010092-uftc8inx 648 8 nationwide nationwide RB cord-010092-uftc8inx 648 9 , , , cord-010092-uftc8inx 648 10 education education NN cord-010092-uftc8inx 648 11 and and CC cord-010092-uftc8inx 648 12 recruitment recruitment NN cord-010092-uftc8inx 648 13 campaigns campaign NNS cord-010092-uftc8inx 648 14 on on IN cord-010092-uftc8inx 648 15 were be VBD cord-010092-uftc8inx 648 16 organized organize VBN cord-010092-uftc8inx 648 17 in in IN cord-010092-uftc8inx 648 18 500 500 CD cord-010092-uftc8inx 648 19 pilot pilot NN cord-010092-uftc8inx 648 20 schools school NNS cord-010092-uftc8inx 648 21 . . . cord-010092-uftc8inx 649 1 Additionally additionally RB cord-010092-uftc8inx 649 2 , , , cord-010092-uftc8inx 649 3 media medium NNS cord-010092-uftc8inx 649 4 and and CC cord-010092-uftc8inx 649 5 public public JJ cord-010092-uftc8inx 649 6 relation relation NN cord-010092-uftc8inx 649 7 campaigns campaign NNS cord-010092-uftc8inx 649 8 on on IN cord-010092-uftc8inx 649 9 blood blood NN cord-010092-uftc8inx 649 10 donation donation NN cord-010092-uftc8inx 649 11 were be VBD cord-010092-uftc8inx 649 12 organized organize VBN cord-010092-uftc8inx 649 13 throughout throughout IN cord-010092-uftc8inx 649 14 the the DT cord-010092-uftc8inx 649 15 country country NN cord-010092-uftc8inx 649 16 . . . cord-010092-uftc8inx 650 1 Results result NNS cord-010092-uftc8inx 650 2 : : : cord-010092-uftc8inx 650 3 ( ( -LRB- cord-010092-uftc8inx 650 4 1 1 LS cord-010092-uftc8inx 650 5 ) ) -RRB- cord-010092-uftc8inx 651 1 Existing exist VBG cord-010092-uftc8inx 651 2 curricula curriculum NNS cord-010092-uftc8inx 651 3 and and CC cord-010092-uftc8inx 651 4 textbooks textbook NNS cord-010092-uftc8inx 651 5 relevant relevant JJ cord-010092-uftc8inx 651 6 to to IN cord-010092-uftc8inx 651 7 promoting promote VBG cord-010092-uftc8inx 651 8 blood blood NN cord-010092-uftc8inx 651 9 donation donation NN cord-010092-uftc8inx 651 10 were be VBD cord-010092-uftc8inx 651 11 reviewed review VBN cord-010092-uftc8inx 651 12 , , , cord-010092-uftc8inx 651 13 revised revise VBN cord-010092-uftc8inx 651 14 and and CC cord-010092-uftc8inx 651 15 reported report VBN cord-010092-uftc8inx 651 16 to to IN cord-010092-uftc8inx 651 17 the the DT cord-010092-uftc8inx 651 18 Board Board NNP cord-010092-uftc8inx 651 19 of of IN cord-010092-uftc8inx 651 20 Education Education NNP cord-010092-uftc8inx 651 21 of of IN cord-010092-uftc8inx 651 22 MoNE MoNE NNP cord-010092-uftc8inx 651 23 . . . cord-010092-uftc8inx 652 1 ( ( -LRB- cord-010092-uftc8inx 652 2 2 2 LS cord-010092-uftc8inx 652 3 ) ) -RRB- cord-010092-uftc8inx 652 4 Corresponding correspond VBG cord-010092-uftc8inx 652 5 educational educational JJ cord-010092-uftc8inx 652 6 materials material NNS cord-010092-uftc8inx 652 7 for for IN cord-010092-uftc8inx 652 8 students student NNS cord-010092-uftc8inx 652 9 and and CC cord-010092-uftc8inx 652 10 teachers teacher NNS cord-010092-uftc8inx 652 11 were be VBD cord-010092-uftc8inx 652 12 developed develop VBN cord-010092-uftc8inx 652 13 and and CC cord-010092-uftc8inx 652 14 distributed distribute VBN cord-010092-uftc8inx 652 15 . . . cord-010092-uftc8inx 653 1 ( ( -LRB- cord-010092-uftc8inx 653 2 3 3 LS cord-010092-uftc8inx 653 3 ) ) -RRB- cord-010092-uftc8inx 653 4 Blood blood NN cord-010092-uftc8inx 653 5 Donation donation NN cord-010092-uftc8inx 653 6 Clubs Clubs NNPS cord-010092-uftc8inx 653 7 were be VBD cord-010092-uftc8inx 653 8 established establish VBN cord-010092-uftc8inx 653 9 in in IN cord-010092-uftc8inx 653 10 500 500 CD cord-010092-uftc8inx 653 11 pilot pilot NN cord-010092-uftc8inx 653 12 schools school NNS cord-010092-uftc8inx 653 13 . . . cord-010092-uftc8inx 654 1 ( ( -LRB- cord-010092-uftc8inx 654 2 4 4 LS cord-010092-uftc8inx 654 3 ) ) -RRB- cord-010092-uftc8inx 654 4 Trainings training NNS cord-010092-uftc8inx 654 5 were be VBD cord-010092-uftc8inx 654 6 conducted conduct VBN cord-010092-uftc8inx 654 7 for for IN cord-010092-uftc8inx 654 8 688 688 CD cord-010092-uftc8inx 654 9 personnel personnel NNS cord-010092-uftc8inx 654 10 of of IN cord-010092-uftc8inx 654 11 MoH MoH NNP cord-010092-uftc8inx 654 12 and and CC cord-010092-uftc8inx 654 13 TRC TRC NNP cord-010092-uftc8inx 654 14 on on IN cord-010092-uftc8inx 654 15 blood blood NN cord-010092-uftc8inx 654 16 donation donation NN cord-010092-uftc8inx 654 17 regarding regard VBG cord-010092-uftc8inx 654 18 their -PRON- PRP$ cord-010092-uftc8inx 654 19 responsibilities responsibility NNS cord-010092-uftc8inx 654 20 . . . cord-010092-uftc8inx 655 1 ( ( -LRB- cord-010092-uftc8inx 655 2 5 5 LS cord-010092-uftc8inx 655 3 ) ) -RRB- cord-010092-uftc8inx 656 1 Cascade cascade JJ cord-010092-uftc8inx 656 2 trainings training NNS cord-010092-uftc8inx 656 3 were be VBD cord-010092-uftc8inx 656 4 conducted conduct VBN cord-010092-uftc8inx 656 5 for for IN cord-010092-uftc8inx 656 6 3218 3218 CD cord-010092-uftc8inx 656 7 personnel personnel NNS cord-010092-uftc8inx 656 8 of of IN cord-010092-uftc8inx 656 9 transfusion transfusion NN cord-010092-uftc8inx 656 10 centers center NNS cord-010092-uftc8inx 656 11 and and CC cord-010092-uftc8inx 656 12 4399 4399 CD cord-010092-uftc8inx 656 13 school school NN cord-010092-uftc8inx 656 14 principals principal NNS cord-010092-uftc8inx 656 15 in in IN cord-010092-uftc8inx 656 16 81 81 CD cord-010092-uftc8inx 656 17 provinces province NNS cord-010092-uftc8inx 656 18 . . . cord-010092-uftc8inx 657 1 ( ( -LRB- cord-010092-uftc8inx 657 2 6 6 LS cord-010092-uftc8inx 657 3 ) ) -RRB- cord-010092-uftc8inx 657 4 Information information NN cord-010092-uftc8inx 657 5 seminars seminar NNS cord-010092-uftc8inx 657 6 were be VBD cord-010092-uftc8inx 657 7 delivered deliver VBN cord-010092-uftc8inx 657 8 to to IN cord-010092-uftc8inx 657 9 251.475 251.475 CD cord-010092-uftc8inx 657 10 students student NNS cord-010092-uftc8inx 657 11 and and CC cord-010092-uftc8inx 657 12 15.739 15.739 CD cord-010092-uftc8inx 657 13 teachers teacher NNS cord-010092-uftc8inx 657 14 and and CC cord-010092-uftc8inx 657 15 family family NN cord-010092-uftc8inx 657 16 members member NNS cord-010092-uftc8inx 657 17 of of IN cord-010092-uftc8inx 657 18 students student NNS cord-010092-uftc8inx 657 19 during during IN cord-010092-uftc8inx 657 20 school school NN cord-010092-uftc8inx 657 21 campaigns campaign NNS cord-010092-uftc8inx 657 22 . . . cord-010092-uftc8inx 658 1 ( ( -LRB- cord-010092-uftc8inx 658 2 7 7 CD cord-010092-uftc8inx 658 3 ) ) -RRB- cord-010092-uftc8inx 658 4 Four four CD cord-010092-uftc8inx 658 5 animation animation NN cord-010092-uftc8inx 658 6 films film NNS cord-010092-uftc8inx 658 7 on on IN cord-010092-uftc8inx 658 8 blood blood NN cord-010092-uftc8inx 658 9 donation donation NN cord-010092-uftc8inx 658 10 were be VBD cord-010092-uftc8inx 658 11 produced produce VBN cord-010092-uftc8inx 658 12 and and CC cord-010092-uftc8inx 658 13 broadcasted broadcast VBN cord-010092-uftc8inx 658 14 on on IN cord-010092-uftc8inx 658 15 the the DT cord-010092-uftc8inx 658 16 national national JJ cord-010092-uftc8inx 658 17 TV tv NN cord-010092-uftc8inx 658 18 channel channel NN cord-010092-uftc8inx 658 19 ( ( -LRB- cord-010092-uftc8inx 658 20 TRT TRT NNP cord-010092-uftc8inx 658 21 ) ) -RRB- cord-010092-uftc8inx 658 22 . . . cord-010092-uftc8inx 659 1 ( ( -LRB- cord-010092-uftc8inx 659 2 8) 8) NNP cord-010092-uftc8inx 659 3 Three three CD cord-010092-uftc8inx 659 4 different different JJ cord-010092-uftc8inx 659 5 computer computer NN cord-010092-uftc8inx 659 6 games game NNS cord-010092-uftc8inx 659 7 targeting target VBG cord-010092-uftc8inx 659 8 different different JJ cord-010092-uftc8inx 659 9 age age NN cord-010092-uftc8inx 659 10 groups group NNS cord-010092-uftc8inx 659 11 were be VBD cord-010092-uftc8inx 659 12 developed develop VBN cord-010092-uftc8inx 659 13 and and CC cord-010092-uftc8inx 659 14 uploaded upload VBN cord-010092-uftc8inx 659 15 to to IN cord-010092-uftc8inx 659 16 the the DT cord-010092-uftc8inx 659 17 web web NN cord-010092-uftc8inx 659 18 portal portal NN cord-010092-uftc8inx 659 19 of of IN cord-010092-uftc8inx 659 20 the the DT cord-010092-uftc8inx 659 21 project project NN cord-010092-uftc8inx 659 22 and and CC cord-010092-uftc8inx 659 23 distributed distribute VBN cord-010092-uftc8inx 659 24 to to IN cord-010092-uftc8inx 659 25 the the DT cord-010092-uftc8inx 659 26 pilot pilot NN cord-010092-uftc8inx 659 27 schools school NNS cord-010092-uftc8inx 659 28 . . . cord-010092-uftc8inx 660 1 ( ( -LRB- cord-010092-uftc8inx 660 2 9 9 CD cord-010092-uftc8inx 660 3 ) ) -RRB- cord-010092-uftc8inx 660 4 Media medium NNS cord-010092-uftc8inx 660 5 spots spot NNS cord-010092-uftc8inx 660 6 were be VBD cord-010092-uftc8inx 660 7 produced produce VBN cord-010092-uftc8inx 660 8 and and CC cord-010092-uftc8inx 660 9 broadcasted broadcast VBN cord-010092-uftc8inx 660 10 3.851 3.851 CD cord-010092-uftc8inx 660 11 times time NNS cord-010092-uftc8inx 660 12 in in IN cord-010092-uftc8inx 660 13 33 33 CD cord-010092-uftc8inx 660 14 different different JJ cord-010092-uftc8inx 660 15 TV tv NN cord-010092-uftc8inx 660 16 and and CC cord-010092-uftc8inx 660 17 Radio radio NN cord-010092-uftc8inx 660 18 channels channel NNS cord-010092-uftc8inx 660 19 . . . cord-010092-uftc8inx 661 1 ( ( -LRB- cord-010092-uftc8inx 661 2 10 10 CD cord-010092-uftc8inx 661 3 ) ) -RRB- cord-010092-uftc8inx 662 1 Billboard billboard NN cord-010092-uftc8inx 662 2 posters poster NNS cord-010092-uftc8inx 662 3 and and CC cord-010092-uftc8inx 662 4 brochures brochure NNS cord-010092-uftc8inx 662 5 were be VBD cord-010092-uftc8inx 662 6 prepared prepare VBN cord-010092-uftc8inx 662 7 and and CC cord-010092-uftc8inx 662 8 distributed distribute VBN cord-010092-uftc8inx 662 9 to to IN cord-010092-uftc8inx 662 10 81 81 CD cord-010092-uftc8inx 662 11 provinces province NNS cord-010092-uftc8inx 662 12 for for IN cord-010092-uftc8inx 662 13 raising raise VBG cord-010092-uftc8inx 662 14 public public JJ cord-010092-uftc8inx 662 15 awareness awareness NN cord-010092-uftc8inx 662 16 . . . cord-010092-uftc8inx 663 1 ( ( -LRB- cord-010092-uftc8inx 663 2 11 11 CD cord-010092-uftc8inx 663 3 ) ) -RRB- cord-010092-uftc8inx 664 1 Advertisements advertisement NNS cord-010092-uftc8inx 664 2 about about IN cord-010092-uftc8inx 664 3 the the DT cord-010092-uftc8inx 664 4 project project NN cord-010092-uftc8inx 664 5 and and CC cord-010092-uftc8inx 664 6 the the DT cord-010092-uftc8inx 664 7 importance importance NN cord-010092-uftc8inx 664 8 of of IN cord-010092-uftc8inx 664 9 VNRD VNRD NNP cord-010092-uftc8inx 664 10 were be VBD cord-010092-uftc8inx 664 11 displayed display VBN cord-010092-uftc8inx 664 12 386 386 CD cord-010092-uftc8inx 664 13 times time NNS cord-010092-uftc8inx 664 14 on on IN cord-010092-uftc8inx 664 15 national national JJ cord-010092-uftc8inx 664 16 and and CC cord-010092-uftc8inx 664 17 local local JJ cord-010092-uftc8inx 664 18 newspapers newspaper NNS cord-010092-uftc8inx 664 19 , , , cord-010092-uftc8inx 664 20 1.117 1.117 CD cord-010092-uftc8inx 664 21 times time NNS cord-010092-uftc8inx 664 22 on on IN cord-010092-uftc8inx 664 23 online online JJ cord-010092-uftc8inx 664 24 news news NN cord-010092-uftc8inx 664 25 , , , cord-010092-uftc8inx 664 26 and and CC cord-010092-uftc8inx 664 27 broadcasted broadcast VBN cord-010092-uftc8inx 664 28 on on IN cord-010092-uftc8inx 664 29 6 6 CD cord-010092-uftc8inx 664 30 national national JJ cord-010092-uftc8inx 664 31 TV tv NN cord-010092-uftc8inx 664 32 channels channel NNS cord-010092-uftc8inx 664 33 . . . cord-010092-uftc8inx 665 1 ( ( -LRB- cord-010092-uftc8inx 665 2 12 12 CD cord-010092-uftc8inx 665 3 ) ) -RRB- cord-010092-uftc8inx 666 1 During during IN cord-010092-uftc8inx 666 2 the the DT cord-010092-uftc8inx 666 3 campaigns campaign NNS cord-010092-uftc8inx 666 4 , , , cord-010092-uftc8inx 666 5 28.310 28.310 CD cord-010092-uftc8inx 666 6 units unit NNS cord-010092-uftc8inx 666 7 of of IN cord-010092-uftc8inx 666 8 whole whole JJ cord-010092-uftc8inx 666 9 blood blood NN cord-010092-uftc8inx 666 10 were be VBD cord-010092-uftc8inx 666 11 collected collect VBN cord-010092-uftc8inx 666 12 in in IN cord-010092-uftc8inx 666 13 pilot pilot NN cord-010092-uftc8inx 666 14 schools school NNS cord-010092-uftc8inx 666 15 . . . cord-010092-uftc8inx 667 1 ( ( -LRB- cord-010092-uftc8inx 667 2 13 13 CD cord-010092-uftc8inx 667 3 ) ) -RRB- cord-010092-uftc8inx 668 1 Visibility visibility NN cord-010092-uftc8inx 668 2 kits kit NNS cord-010092-uftc8inx 668 3 to to TO cord-010092-uftc8inx 668 4 recruit recruit VB cord-010092-uftc8inx 668 5 future future JJ cord-010092-uftc8inx 668 6 blood blood NN cord-010092-uftc8inx 668 7 donors donor NNS cord-010092-uftc8inx 668 8 are be VBP cord-010092-uftc8inx 668 9 prepared prepare VBN cord-010092-uftc8inx 668 10 and and CC cord-010092-uftc8inx 668 11 distributed distribute VBN cord-010092-uftc8inx 668 12 throughout throughout IN cord-010092-uftc8inx 668 13 the the DT cord-010092-uftc8inx 668 14 project project NN cord-010092-uftc8inx 668 15 activities activity NNS cord-010092-uftc8inx 668 16 . . . cord-010092-uftc8inx 669 1 ( ( -LRB- cord-010092-uftc8inx 669 2 14 14 CD cord-010092-uftc8inx 669 3 ) ) -RRB- cord-010092-uftc8inx 669 4 Awareness awareness NN cord-010092-uftc8inx 669 5 and and CC cord-010092-uftc8inx 669 6 knowledge knowledge NN cord-010092-uftc8inx 669 7 level level NN cord-010092-uftc8inx 669 8 of of IN cord-010092-uftc8inx 669 9 students student NNS cord-010092-uftc8inx 669 10 and and CC cord-010092-uftc8inx 669 11 their -PRON- PRP$ cord-010092-uftc8inx 669 12 teachers teacher NNS cord-010092-uftc8inx 669 13 / / SYM cord-010092-uftc8inx 669 14 parents parent NNS cord-010092-uftc8inx 669 15 on on IN cord-010092-uftc8inx 669 16 the the DT cord-010092-uftc8inx 669 17 importance importance NN cord-010092-uftc8inx 669 18 of of IN cord-010092-uftc8inx 669 19 blood blood NN cord-010092-uftc8inx 669 20 donation donation NN cord-010092-uftc8inx 669 21 are be VBP cord-010092-uftc8inx 669 22 increased increase VBN cord-010092-uftc8inx 669 23 to to IN cord-010092-uftc8inx 669 24 32.07 32.07 CD cord-010092-uftc8inx 669 25 % % NN cord-010092-uftc8inx 669 26 and and CC cord-010092-uftc8inx 669 27 35.99 35.99 CD cord-010092-uftc8inx 669 28 % % NN cord-010092-uftc8inx 669 29 respectively respectively RB cord-010092-uftc8inx 669 30 , , , cord-010092-uftc8inx 669 31 assessed assess VBN cord-010092-uftc8inx 669 32 through through IN cord-010092-uftc8inx 669 33 pretest pretest NN cord-010092-uftc8inx 669 34 and and CC cord-010092-uftc8inx 669 35 posttest posttest NNP cord-010092-uftc8inx 669 36 . . . cord-010092-uftc8inx 670 1 Voluntary voluntary JJ cord-010092-uftc8inx 670 2 non non JJ cord-010092-uftc8inx 670 3 - - JJ cord-010092-uftc8inx 670 4 remunerated remunerated JJ cord-010092-uftc8inx 670 5 donation donation NN cord-010092-uftc8inx 670 6 rate rate NN cord-010092-uftc8inx 670 7 of of IN cord-010092-uftc8inx 670 8 national national JJ cord-010092-uftc8inx 670 9 demand demand NN cord-010092-uftc8inx 670 10 increased increase VBD cord-010092-uftc8inx 670 11 from from IN cord-010092-uftc8inx 670 12 73.66 73.66 CD cord-010092-uftc8inx 670 13 % % NN cord-010092-uftc8inx 670 14 to to IN cord-010092-uftc8inx 670 15 82.54 82.54 CD cord-010092-uftc8inx 670 16 in in IN cord-010092-uftc8inx 670 17 two two CD cord-010092-uftc8inx 670 18 years year NNS cord-010092-uftc8inx 670 19 . . . cord-010092-uftc8inx 671 1 Summary Summary NNP cord-010092-uftc8inx 671 2 / / SYM cord-010092-uftc8inx 671 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 671 4 : : : cord-010092-uftc8inx 672 1 Training training NN cord-010092-uftc8inx 672 2 and and CC cord-010092-uftc8inx 672 3 campaign campaign NN cord-010092-uftc8inx 672 4 programmes programme NNS cord-010092-uftc8inx 672 5 successfully successfully RB cord-010092-uftc8inx 672 6 increased increase VBD cord-010092-uftc8inx 672 7 the the DT cord-010092-uftc8inx 672 8 knowledge knowledge NN cord-010092-uftc8inx 672 9 on on IN cord-010092-uftc8inx 672 10 blood blood NN cord-010092-uftc8inx 672 11 donation donation NN cord-010092-uftc8inx 672 12 . . . cord-010092-uftc8inx 673 1 To to TO cord-010092-uftc8inx 673 2 achieve achieve VB cord-010092-uftc8inx 673 3 national national JJ cord-010092-uftc8inx 673 4 self self NN cord-010092-uftc8inx 673 5 - - HYPH cord-010092-uftc8inx 673 6 sufficient sufficient JJ cord-010092-uftc8inx 673 7 safe safe JJ cord-010092-uftc8inx 673 8 blood blood NN cord-010092-uftc8inx 673 9 supply supply NN cord-010092-uftc8inx 673 10 , , , cord-010092-uftc8inx 673 11 efforts effort NNS cord-010092-uftc8inx 673 12 for for IN cord-010092-uftc8inx 673 13 recruitment recruitment NN cord-010092-uftc8inx 673 14 should should MD cord-010092-uftc8inx 673 15 be be VB cord-010092-uftc8inx 673 16 continued continue VBN cord-010092-uftc8inx 673 17 . . . cord-010092-uftc8inx 674 1 Background background NN cord-010092-uftc8inx 674 2 : : : cord-010092-uftc8inx 675 1 Despite despite IN cord-010092-uftc8inx 675 2 70 70 CD cord-010092-uftc8inx 675 3 % % NN cord-010092-uftc8inx 675 4 of of IN cord-010092-uftc8inx 675 5 Pakistan Pakistan NNP cord-010092-uftc8inx 675 6 's 's POS cord-010092-uftc8inx 675 7 population population NN cord-010092-uftc8inx 675 8 being be VBG cord-010092-uftc8inx 675 9 under under IN cord-010092-uftc8inx 675 10 29 29 CD cord-010092-uftc8inx 675 11 years year NNS cord-010092-uftc8inx 675 12 , , , cord-010092-uftc8inx 675 13 only only RB cord-010092-uftc8inx 675 14 10 10 CD cord-010092-uftc8inx 675 15 % % NN cord-010092-uftc8inx 675 16 of of IN cord-010092-uftc8inx 675 17 blood blood NN cord-010092-uftc8inx 675 18 supplies supply NNS cord-010092-uftc8inx 675 19 come come VBP cord-010092-uftc8inx 675 20 from from IN cord-010092-uftc8inx 675 21 voluntary voluntary JJ cord-010092-uftc8inx 675 22 donors donor NNS cord-010092-uftc8inx 675 23 while while IN cord-010092-uftc8inx 675 24 remaining remain VBG cord-010092-uftc8inx 675 25 blood blood NN cord-010092-uftc8inx 675 26 is be VBZ cord-010092-uftc8inx 675 27 collected collect VBN cord-010092-uftc8inx 675 28 from from IN cord-010092-uftc8inx 675 29 ' ' '' cord-010092-uftc8inx 675 30 Family Family NNP cord-010092-uftc8inx 675 31 Replacement Replacement NNP cord-010092-uftc8inx 675 32 Donors Donors NNPS cord-010092-uftc8inx 675 33 ' ' POS cord-010092-uftc8inx 675 34 . . . cord-010092-uftc8inx 676 1 In in IN cord-010092-uftc8inx 676 2 Pakistan Pakistan NNP cord-010092-uftc8inx 676 3 the the DT cord-010092-uftc8inx 676 4 system system NN cord-010092-uftc8inx 676 5 has have VBZ cord-010092-uftc8inx 676 6 outsourced outsource VBN cord-010092-uftc8inx 676 7 the the DT cord-010092-uftc8inx 676 8 mobilization mobilization NN cord-010092-uftc8inx 676 9 of of IN cord-010092-uftc8inx 676 10 blood blood NN cord-010092-uftc8inx 676 11 donors donor NNS cord-010092-uftc8inx 676 12 to to IN cord-010092-uftc8inx 676 13 the the DT cord-010092-uftc8inx 676 14 patient patient JJ cord-010092-uftc8inx 676 15 families family NNS cord-010092-uftc8inx 676 16 . . . cord-010092-uftc8inx 677 1 As as IN cord-010092-uftc8inx 677 2 a a DT cord-010092-uftc8inx 677 3 result result NN cord-010092-uftc8inx 677 4 many many JJ cord-010092-uftc8inx 677 5 people people NNS cord-010092-uftc8inx 677 6 reach reach VBP cord-010092-uftc8inx 677 7 out out RP cord-010092-uftc8inx 677 8 to to IN cord-010092-uftc8inx 677 9 their -PRON- PRP$ cord-010092-uftc8inx 677 10 networks network NNS cord-010092-uftc8inx 677 11 including include VBG cord-010092-uftc8inx 677 12 on on IN cord-010092-uftc8inx 677 13 Facebook Facebook NNP cord-010092-uftc8inx 677 14 to to TO cord-010092-uftc8inx 677 15 locate locate VB cord-010092-uftc8inx 677 16 blood blood NN cord-010092-uftc8inx 677 17 donors donor NNS cord-010092-uftc8inx 677 18 . . . cord-010092-uftc8inx 678 1 There there EX cord-010092-uftc8inx 678 2 are be VBP cord-010092-uftc8inx 678 3 thousands thousand NNS cord-010092-uftc8inx 678 4 of of IN cord-010092-uftc8inx 678 5 posts post NNS cord-010092-uftc8inx 678 6 each each DT cord-010092-uftc8inx 678 7 month month NN cord-010092-uftc8inx 678 8 in in IN cord-010092-uftc8inx 678 9 Pakistan Pakistan NNP cord-010092-uftc8inx 678 10 seeking seek VBG cord-010092-uftc8inx 678 11 blood blood NN cord-010092-uftc8inx 678 12 donors donor NNS cord-010092-uftc8inx 678 13 on on IN cord-010092-uftc8inx 678 14 Facebook Facebook NNP cord-010092-uftc8inx 678 15 . . . cord-010092-uftc8inx 679 1 To to TO cord-010092-uftc8inx 679 2 facilitate facilitate VB cord-010092-uftc8inx 679 3 needy needy JJ cord-010092-uftc8inx 679 4 families family NNS cord-010092-uftc8inx 679 5 , , , cord-010092-uftc8inx 679 6 the the DT cord-010092-uftc8inx 679 7 global global JJ cord-010092-uftc8inx 679 8 social social JJ cord-010092-uftc8inx 679 9 media medium NNS cord-010092-uftc8inx 679 10 giant giant NN cord-010092-uftc8inx 679 11 Facebook Facebook NNP cord-010092-uftc8inx 679 12 launched launch VBD cord-010092-uftc8inx 679 13 a a DT cord-010092-uftc8inx 679 14 special special JJ cord-010092-uftc8inx 679 15 blood blood NN cord-010092-uftc8inx 679 16 donation donation NN cord-010092-uftc8inx 679 17 Feature Feature NNP cord-010092-uftc8inx 679 18 for for IN cord-010092-uftc8inx 679 19 Pakistan Pakistan NNP cord-010092-uftc8inx 679 20 in in IN cord-010092-uftc8inx 679 21 collaboration collaboration NN cord-010092-uftc8inx 679 22 with with IN cord-010092-uftc8inx 679 23 SBTP SBTP NNP cord-010092-uftc8inx 679 24 , , , cord-010092-uftc8inx 679 25 Pakistan Pakistan NNP cord-010092-uftc8inx 679 26 . . . cord-010092-uftc8inx 680 1 The the DT cord-010092-uftc8inx 680 2 Feature feature NN cord-010092-uftc8inx 680 3 makes make VBZ cord-010092-uftc8inx 680 4 it -PRON- PRP cord-010092-uftc8inx 680 5 easier easy JJR cord-010092-uftc8inx 680 6 for for IN cord-010092-uftc8inx 680 7 people people NNS cord-010092-uftc8inx 680 8 to to TO cord-010092-uftc8inx 680 9 sign sign VB cord-010092-uftc8inx 680 10 up up RP cord-010092-uftc8inx 680 11 to to TO cord-010092-uftc8inx 680 12 become become VB cord-010092-uftc8inx 680 13 blood blood NN cord-010092-uftc8inx 680 14 donors donor NNS cord-010092-uftc8inx 680 15 and and CC cord-010092-uftc8inx 680 16 helps help VBZ cord-010092-uftc8inx 680 17 connect connect VB cord-010092-uftc8inx 680 18 these these DT cord-010092-uftc8inx 680 19 voluntary voluntary JJ cord-010092-uftc8inx 680 20 donors donor NNS cord-010092-uftc8inx 680 21 with with IN cord-010092-uftc8inx 680 22 people people NNS cord-010092-uftc8inx 680 23 and and CC cord-010092-uftc8inx 680 24 organizations organization NNS cord-010092-uftc8inx 680 25 in in IN cord-010092-uftc8inx 680 26 need need NN cord-010092-uftc8inx 680 27 of of IN cord-010092-uftc8inx 680 28 blood blood NN cord-010092-uftc8inx 680 29 . . . cord-010092-uftc8inx 681 1 Similar Similar NNP cord-010092-uftc8inx 681 2 Features Features NNPS cord-010092-uftc8inx 681 3 have have VBP cord-010092-uftc8inx 681 4 been be VBN cord-010092-uftc8inx 681 5 launched launch VBN cord-010092-uftc8inx 681 6 by by IN cord-010092-uftc8inx 681 7 Facebook Facebook NNP cord-010092-uftc8inx 681 8 in in IN cord-010092-uftc8inx 681 9 India India NNP cord-010092-uftc8inx 681 10 , , , cord-010092-uftc8inx 681 11 Bangladesh Bangladesh NNP cord-010092-uftc8inx 681 12 and and CC cord-010092-uftc8inx 681 13 Brazil Brazil NNP cord-010092-uftc8inx 681 14 to to TO cord-010092-uftc8inx 681 15 address address VB cord-010092-uftc8inx 681 16 the the DT cord-010092-uftc8inx 681 17 problem problem NN cord-010092-uftc8inx 681 18 of of IN cord-010092-uftc8inx 681 19 blood blood NN cord-010092-uftc8inx 681 20 shortages shortage NNS cord-010092-uftc8inx 681 21 in in IN cord-010092-uftc8inx 681 22 those those DT cord-010092-uftc8inx 681 23 countries country NNS cord-010092-uftc8inx 681 24 . . . cord-010092-uftc8inx 682 1 However however RB cord-010092-uftc8inx 682 2 , , , cord-010092-uftc8inx 682 3 among among IN cord-010092-uftc8inx 682 4 these these DT cord-010092-uftc8inx 682 5 four four CD cord-010092-uftc8inx 682 6 countries country NNS cord-010092-uftc8inx 682 7 Pakistan Pakistan NNP cord-010092-uftc8inx 682 8 has have VBZ cord-010092-uftc8inx 682 9 unique unique JJ cord-010092-uftc8inx 682 10 position position NN cord-010092-uftc8inx 682 11 because because IN cord-010092-uftc8inx 682 12 of of IN cord-010092-uftc8inx 682 13 the the DT cord-010092-uftc8inx 682 14 existence existence NN cord-010092-uftc8inx 682 15 of of IN cord-010092-uftc8inx 682 16 a a DT cord-010092-uftc8inx 682 17 national national JJ cord-010092-uftc8inx 682 18 counterpart counterpart NN cord-010092-uftc8inx 682 19 , , , cord-010092-uftc8inx 682 20 SBTP SBTP NNP cord-010092-uftc8inx 682 21 which which WDT cord-010092-uftc8inx 682 22 can can MD cord-010092-uftc8inx 682 23 facilitate facilitate VB cord-010092-uftc8inx 682 24 Facebook Facebook NNP cord-010092-uftc8inx 682 25 in in IN cord-010092-uftc8inx 682 26 promoting promote VBG cord-010092-uftc8inx 682 27 its -PRON- PRP$ cord-010092-uftc8inx 682 28 Feature feature NN cord-010092-uftc8inx 682 29 and and CC cord-010092-uftc8inx 682 30 provide provide VB cord-010092-uftc8inx 682 31 the the DT cord-010092-uftc8inx 682 32 feedback feedback NN cord-010092-uftc8inx 682 33 on on IN cord-010092-uftc8inx 682 34 the the DT cord-010092-uftc8inx 682 35 impact impact NN cord-010092-uftc8inx 682 36 of of IN cord-010092-uftc8inx 682 37 this this DT cord-010092-uftc8inx 682 38 innovative innovative JJ cord-010092-uftc8inx 682 39 effort effort NN cord-010092-uftc8inx 682 40 for for IN cord-010092-uftc8inx 682 41 continuous continuous JJ cord-010092-uftc8inx 682 42 improvement improvement NN cord-010092-uftc8inx 682 43 of of IN cord-010092-uftc8inx 682 44 the the DT cord-010092-uftc8inx 682 45 Feature feature NN cord-010092-uftc8inx 682 46 . . . cord-010092-uftc8inx 683 1 Aims aim VBZ cord-010092-uftc8inx 683 2 : : : cord-010092-uftc8inx 684 1 To to TO cord-010092-uftc8inx 684 2 promote promote VB cord-010092-uftc8inx 684 3 voluntary voluntary JJ cord-010092-uftc8inx 684 4 blood blood NN cord-010092-uftc8inx 684 5 donations donation NNS cord-010092-uftc8inx 684 6 and and CC cord-010092-uftc8inx 684 7 blood blood NN cord-010092-uftc8inx 684 8 safety safety NN cord-010092-uftc8inx 684 9 in in IN cord-010092-uftc8inx 684 10 Pakistan Pakistan NNP cord-010092-uftc8inx 684 11 through through IN cord-010092-uftc8inx 684 12 Facebook Facebook NNP cord-010092-uftc8inx 684 13 . . . cord-010092-uftc8inx 685 1 Methods method NNS cord-010092-uftc8inx 685 2 : : : cord-010092-uftc8inx 686 1 The the DT cord-010092-uftc8inx 686 2 Facebook Facebook NNP cord-010092-uftc8inx 686 3 and and CC cord-010092-uftc8inx 686 4 SBTP SBTP NNP cord-010092-uftc8inx 686 5 teams team NNS cord-010092-uftc8inx 686 6 launched launch VBD cord-010092-uftc8inx 686 7 a a DT cord-010092-uftc8inx 686 8 pilot pilot NN cord-010092-uftc8inx 686 9 to to TO cord-010092-uftc8inx 686 10 study study VB cord-010092-uftc8inx 686 11 the the DT cord-010092-uftc8inx 686 12 impact impact NN cord-010092-uftc8inx 686 13 and and CC cord-010092-uftc8inx 686 14 effectiveness effectiveness NN cord-010092-uftc8inx 686 15 of of IN cord-010092-uftc8inx 686 16 the the DT cord-010092-uftc8inx 686 17 Facebook Facebook NNP cord-010092-uftc8inx 686 18 Blood Blood NNP cord-010092-uftc8inx 686 19 Donation Donation NNP cord-010092-uftc8inx 686 20 Feature Feature NNP cord-010092-uftc8inx 686 21 as as IN cord-010092-uftc8inx 686 22 a a DT cord-010092-uftc8inx 686 23 tool tool NN cord-010092-uftc8inx 686 24 of of IN cord-010092-uftc8inx 686 25 community community NN cord-010092-uftc8inx 686 26 engagement engagement NN cord-010092-uftc8inx 686 27 . . . cord-010092-uftc8inx 687 1 A a DT cord-010092-uftc8inx 687 2 six six CD cord-010092-uftc8inx 687 3 months month NNS cord-010092-uftc8inx 687 4 plan plan NN cord-010092-uftc8inx 687 5 has have VBZ cord-010092-uftc8inx 687 6 been be VBN cord-010092-uftc8inx 687 7 chalked chalk VBN cord-010092-uftc8inx 687 8 out out RP cord-010092-uftc8inx 687 9 to to TO cord-010092-uftc8inx 687 10 measure measure VB cord-010092-uftc8inx 687 11 the the DT cord-010092-uftc8inx 687 12 impact impact NN cord-010092-uftc8inx 687 13 of of IN cord-010092-uftc8inx 687 14 this this DT cord-010092-uftc8inx 687 15 tool tool NN cord-010092-uftc8inx 687 16 in in IN cord-010092-uftc8inx 687 17 five five CD cord-010092-uftc8inx 687 18 selected select VBN cord-010092-uftc8inx 687 19 blood blood NN cord-010092-uftc8inx 687 20 centres centre NNS cord-010092-uftc8inx 687 21 . . . cord-010092-uftc8inx 688 1 A a DT cord-010092-uftc8inx 688 2 checklist checklist NN cord-010092-uftc8inx 688 3 called call VBN cord-010092-uftc8inx 688 4 " " `` cord-010092-uftc8inx 688 5 P0 p0 NN cord-010092-uftc8inx 688 6 checklist checklist NN cord-010092-uftc8inx 688 7 " " '' cord-010092-uftc8inx 688 8 was be VBD cord-010092-uftc8inx 688 9 shared share VBN cord-010092-uftc8inx 688 10 with with IN cord-010092-uftc8inx 688 11 these these DT cord-010092-uftc8inx 688 12 blood blood NN cord-010092-uftc8inx 688 13 centres centre NNS cord-010092-uftc8inx 688 14 to to TO cord-010092-uftc8inx 688 15 fulfill fulfill VB cord-010092-uftc8inx 688 16 some some DT cord-010092-uftc8inx 688 17 basic basic JJ cord-010092-uftc8inx 688 18 requirements requirement NNS cord-010092-uftc8inx 688 19 for for IN cord-010092-uftc8inx 688 20 an an DT cord-010092-uftc8inx 688 21 official official JJ cord-010092-uftc8inx 688 22 blood blood NN cord-010092-uftc8inx 688 23 bank bank NN cord-010092-uftc8inx 688 24 page page NN cord-010092-uftc8inx 688 25 including include VBG cord-010092-uftc8inx 688 26 a a DT cord-010092-uftc8inx 688 27 display display NN cord-010092-uftc8inx 688 28 picture picture NN cord-010092-uftc8inx 688 29 , , , cord-010092-uftc8inx 688 30 cover cover NN cord-010092-uftc8inx 688 31 photo photo NN cord-010092-uftc8inx 688 32 , , , cord-010092-uftc8inx 688 33 contact contact NN cord-010092-uftc8inx 688 34 information information NN cord-010092-uftc8inx 688 35 , , , cord-010092-uftc8inx 688 36 directions direction NNS cord-010092-uftc8inx 688 37 , , , cord-010092-uftc8inx 688 38 etc etc FW cord-010092-uftc8inx 688 39 . . . cord-010092-uftc8inx 689 1 Regular regular JJ cord-010092-uftc8inx 689 2 Skype Skype NNP cord-010092-uftc8inx 689 3 meetings meeting NNS cord-010092-uftc8inx 689 4 are be VBP cord-010092-uftc8inx 689 5 held hold VBN cord-010092-uftc8inx 689 6 between between IN cord-010092-uftc8inx 689 7 the the DT cord-010092-uftc8inx 689 8 teams team NNS cord-010092-uftc8inx 689 9 of of IN cord-010092-uftc8inx 689 10 SBTP SBTP NNP cord-010092-uftc8inx 689 11 , , , cord-010092-uftc8inx 689 12 Facebook Facebook NNP cord-010092-uftc8inx 689 13 ( ( -LRB- cord-010092-uftc8inx 689 14 San San NNP cord-010092-uftc8inx 689 15 Francisco Francisco NNP cord-010092-uftc8inx 689 16 and and CC cord-010092-uftc8inx 689 17 Singapore Singapore NNP cord-010092-uftc8inx 689 18 ) ) -RRB- cord-010092-uftc8inx 689 19 and and CC cord-010092-uftc8inx 689 20 the the DT cord-010092-uftc8inx 689 21 blood blood NN cord-010092-uftc8inx 689 22 centres centre NNS cord-010092-uftc8inx 689 23 to to TO cord-010092-uftc8inx 689 24 monitor monitor VB cord-010092-uftc8inx 689 25 the the DT cord-010092-uftc8inx 689 26 progress progress NN cord-010092-uftc8inx 689 27 of of IN cord-010092-uftc8inx 689 28 the the DT cord-010092-uftc8inx 689 29 Pilot Pilot NNP cord-010092-uftc8inx 689 30 and and CC cord-010092-uftc8inx 689 31 generate generate VB cord-010092-uftc8inx 689 32 feedback feedback NN cord-010092-uftc8inx 689 33 . . . cord-010092-uftc8inx 690 1 Results result NNS cord-010092-uftc8inx 690 2 : : : cord-010092-uftc8inx 691 1 The the DT cord-010092-uftc8inx 691 2 Facebook Facebook NNP cord-010092-uftc8inx 691 3 Blood Blood NNP cord-010092-uftc8inx 691 4 Donation Donation NNP cord-010092-uftc8inx 691 5 Feature Feature NNP cord-010092-uftc8inx 691 6 has have VBZ cord-010092-uftc8inx 691 7 recorded record VBN cord-010092-uftc8inx 691 8 remarkable remarkable JJ cord-010092-uftc8inx 691 9 success success NN cord-010092-uftc8inx 691 10 with with IN cord-010092-uftc8inx 691 11 over over IN cord-010092-uftc8inx 691 12 one one CD cord-010092-uftc8inx 691 13 million million CD cord-010092-uftc8inx 691 14 signups signup NNS cord-010092-uftc8inx 691 15 within within IN cord-010092-uftc8inx 691 16 few few JJ cord-010092-uftc8inx 691 17 months month NNS cord-010092-uftc8inx 691 18 in in IN cord-010092-uftc8inx 691 19 Pakistan Pakistan NNP cord-010092-uftc8inx 691 20 . . . cord-010092-uftc8inx 692 1 The the DT cord-010092-uftc8inx 692 2 blood blood NN cord-010092-uftc8inx 692 3 centres centre NNS cord-010092-uftc8inx 692 4 participating participate VBG cord-010092-uftc8inx 692 5 in in IN cord-010092-uftc8inx 692 6 the the DT cord-010092-uftc8inx 692 7 Pakistan Pakistan NNP cord-010092-uftc8inx 692 8 study study NN cord-010092-uftc8inx 692 9 have have VBP cord-010092-uftc8inx 692 10 experienced experience VBN cord-010092-uftc8inx 692 11 enhancement enhancement NN cord-010092-uftc8inx 692 12 in in IN cord-010092-uftc8inx 692 13 the the DT cord-010092-uftc8inx 692 14 voluntary voluntary JJ cord-010092-uftc8inx 692 15 blood blood NN cord-010092-uftc8inx 692 16 donations donation NNS cord-010092-uftc8inx 692 17 trend trend VBP cord-010092-uftc8inx 692 18 with with IN cord-010092-uftc8inx 692 19 3 3 CD cord-010092-uftc8inx 692 20 - - SYM cord-010092-uftc8inx 692 21 10 10 CD cord-010092-uftc8inx 692 22 walk walk NN cord-010092-uftc8inx 692 23 - - HYPH cord-010092-uftc8inx 692 24 in in RP cord-010092-uftc8inx 692 25 donors donor NNS cord-010092-uftc8inx 692 26 and and CC cord-010092-uftc8inx 692 27 an an DT cord-010092-uftc8inx 692 28 average average NN cord-010092-uftc8inx 692 29 of of IN cord-010092-uftc8inx 692 30 more more JJR cord-010092-uftc8inx 692 31 than than IN cord-010092-uftc8inx 692 32 20 20 CD cord-010092-uftc8inx 692 33 telephonic telephonic JJ cord-010092-uftc8inx 692 34 queries query NNS cord-010092-uftc8inx 692 35 regarding regard VBG cord-010092-uftc8inx 692 36 voluntary voluntary JJ cord-010092-uftc8inx 692 37 blood blood NN cord-010092-uftc8inx 692 38 donation donation NN cord-010092-uftc8inx 692 39 per per IN cord-010092-uftc8inx 692 40 month month NN cord-010092-uftc8inx 692 41 in in IN cord-010092-uftc8inx 692 42 each each DT cord-010092-uftc8inx 692 43 center center NN cord-010092-uftc8inx 692 44 . . . cord-010092-uftc8inx 693 1 The the DT cord-010092-uftc8inx 693 2 trend trend NN cord-010092-uftc8inx 693 3 is be VBZ cord-010092-uftc8inx 693 4 gradually gradually RB cord-010092-uftc8inx 693 5 surging surge VBG cord-010092-uftc8inx 693 6 as as IN cord-010092-uftc8inx 693 7 the the DT cord-010092-uftc8inx 693 8 Feature feature NN cord-010092-uftc8inx 693 9 is be VBZ cord-010092-uftc8inx 693 10 being be VBG cord-010092-uftc8inx 693 11 refined refine VBN cord-010092-uftc8inx 693 12 on on IN cord-010092-uftc8inx 693 13 the the DT cord-010092-uftc8inx 693 14 basis basis NN cord-010092-uftc8inx 693 15 of of IN cord-010092-uftc8inx 693 16 feedback feedback NN cord-010092-uftc8inx 693 17 received receive VBN cord-010092-uftc8inx 693 18 . . . cord-010092-uftc8inx 694 1 The the DT cord-010092-uftc8inx 694 2 Pilot Pilot NNP cord-010092-uftc8inx 694 3 will will MD cord-010092-uftc8inx 694 4 end end VB cord-010092-uftc8inx 694 5 in in IN cord-010092-uftc8inx 694 6 June June NNP cord-010092-uftc8inx 694 7 2019 2019 CD cord-010092-uftc8inx 694 8 . . . cord-010092-uftc8inx 695 1 The the DT cord-010092-uftc8inx 695 2 statistics statistic NNS cord-010092-uftc8inx 695 3 generated generate VBN cord-010092-uftc8inx 695 4 since since IN cord-010092-uftc8inx 695 5 January January NNP cord-010092-uftc8inx 695 6 2019 2019 CD cord-010092-uftc8inx 695 7 are be VBP cord-010092-uftc8inx 695 8 very very RB cord-010092-uftc8inx 695 9 encouraging encouraging JJ cord-010092-uftc8inx 695 10 and and CC cord-010092-uftc8inx 695 11 underscore underscore VB cord-010092-uftc8inx 695 12 the the DT cord-010092-uftc8inx 695 13 importance importance NN cord-010092-uftc8inx 695 14 of of IN cord-010092-uftc8inx 695 15 social social JJ cord-010092-uftc8inx 695 16 media medium NNS cord-010092-uftc8inx 695 17 in in IN cord-010092-uftc8inx 695 18 reaching reach VBG cord-010092-uftc8inx 695 19 out out RP cord-010092-uftc8inx 695 20 to to IN cord-010092-uftc8inx 695 21 the the DT cord-010092-uftc8inx 695 22 untapped untapped JJ cord-010092-uftc8inx 695 23 potential potential JJ cord-010092-uftc8inx 695 24 blood blood NN cord-010092-uftc8inx 695 25 donors donor NNS cord-010092-uftc8inx 695 26 . . . cord-010092-uftc8inx 696 1 The the DT cord-010092-uftc8inx 696 2 study study NN cord-010092-uftc8inx 696 3 will will MD cord-010092-uftc8inx 696 4 be be VB cord-010092-uftc8inx 696 5 used use VBN cord-010092-uftc8inx 696 6 to to TO cord-010092-uftc8inx 696 7 plan plan VB cord-010092-uftc8inx 696 8 an an DT cord-010092-uftc8inx 696 9 effective effective JJ cord-010092-uftc8inx 696 10 nationwide nationwide JJ cord-010092-uftc8inx 696 11 strategy strategy NN cord-010092-uftc8inx 696 12 to to TO cord-010092-uftc8inx 696 13 increase increase VB cord-010092-uftc8inx 696 14 donor donor NN cord-010092-uftc8inx 696 15 mobilization mobilization NN cord-010092-uftc8inx 696 16 , , , cord-010092-uftc8inx 696 17 recruitment recruitment NN cord-010092-uftc8inx 696 18 and and CC cord-010092-uftc8inx 696 19 retention retention NN cord-010092-uftc8inx 696 20 . . . cord-010092-uftc8inx 697 1 Background background NN cord-010092-uftc8inx 697 2 : : : cord-010092-uftc8inx 698 1 In in IN cord-010092-uftc8inx 698 2 our -PRON- PRP$ cord-010092-uftc8inx 698 3 region region NN cord-010092-uftc8inx 698 4 , , , cord-010092-uftc8inx 698 5 an an DT cord-010092-uftc8inx 698 6 increasing increase VBG cord-010092-uftc8inx 698 7 number number NN cord-010092-uftc8inx 698 8 of of IN cord-010092-uftc8inx 698 9 patients patient NNS cord-010092-uftc8inx 698 10 of of IN cord-010092-uftc8inx 698 11 African african JJ cord-010092-uftc8inx 698 12 or or CC cord-010092-uftc8inx 698 13 Asian asian JJ cord-010092-uftc8inx 698 14 origin origin NN cord-010092-uftc8inx 698 15 with with IN cord-010092-uftc8inx 698 16 sickle sickle NN cord-010092-uftc8inx 698 17 cell cell NN cord-010092-uftc8inx 698 18 disease disease NN cord-010092-uftc8inx 698 19 ( ( -LRB- cord-010092-uftc8inx 698 20 SCD SCD NNP cord-010092-uftc8inx 698 21 ) ) -RRB- cord-010092-uftc8inx 698 22 or or CC cord-010092-uftc8inx 698 23 transfusion transfusion NN cord-010092-uftc8inx 698 24 dependent dependent JJ cord-010092-uftc8inx 698 25 thalassemia thalassemia NN cord-010092-uftc8inx 698 26 ( ( -LRB- cord-010092-uftc8inx 698 27 TDT TDT NNP cord-010092-uftc8inx 698 28 ) ) -RRB- cord-010092-uftc8inx 698 29 require require VBP cord-010092-uftc8inx 698 30 red red JJ cord-010092-uftc8inx 698 31 blood blood NN cord-010092-uftc8inx 698 32 cell cell NN cord-010092-uftc8inx 698 33 ( ( -LRB- cord-010092-uftc8inx 698 34 RBC RBC NNP cord-010092-uftc8inx 698 35 ) ) -RRB- cord-010092-uftc8inx 698 36 transfusions transfusion NNS cord-010092-uftc8inx 698 37 , , , cord-010092-uftc8inx 698 38 and and CC cord-010092-uftc8inx 698 39 many many JJ cord-010092-uftc8inx 698 40 have have VBP cord-010092-uftc8inx 698 41 RBC RBC NNP cord-010092-uftc8inx 698 42 alloantibodies alloantibody NNS cord-010092-uftc8inx 698 43 . . . cord-010092-uftc8inx 699 1 Selecting select VBG cord-010092-uftc8inx 699 2 optimally optimally RB cord-010092-uftc8inx 699 3 matched match VBN cord-010092-uftc8inx 699 4 RBC RBC NNP cord-010092-uftc8inx 699 5 units unit NNS cord-010092-uftc8inx 699 6 for for IN cord-010092-uftc8inx 699 7 these these DT cord-010092-uftc8inx 699 8 patients patient NNS cord-010092-uftc8inx 699 9 is be VBZ cord-010092-uftc8inx 699 10 essential essential JJ cord-010092-uftc8inx 699 11 for for IN cord-010092-uftc8inx 699 12 preventing prevent VBG cord-010092-uftc8inx 699 13 not not RB cord-010092-uftc8inx 699 14 only only RB cord-010092-uftc8inx 699 15 acute acute JJ cord-010092-uftc8inx 699 16 hemolysis hemolysis NN cord-010092-uftc8inx 699 17 but but CC cord-010092-uftc8inx 699 18 also also RB cord-010092-uftc8inx 699 19 further further JJ cord-010092-uftc8inx 699 20 alloimmunisation alloimmunisation NN cord-010092-uftc8inx 699 21 . . . cord-010092-uftc8inx 700 1 Beside beside IN cord-010092-uftc8inx 700 2 antigen antigen NN cord-010092-uftc8inx 700 3 - - HYPH cord-010092-uftc8inx 700 4 matching matching NN cord-010092-uftc8inx 700 5 for for IN cord-010092-uftc8inx 700 6 ABO ABO NNP cord-010092-uftc8inx 700 7 , , , cord-010092-uftc8inx 700 8 Rh Rh NNP cord-010092-uftc8inx 700 9 D D NNP cord-010092-uftc8inx 700 10 , , , cord-010092-uftc8inx 700 11 C C NNP cord-010092-uftc8inx 700 12 , , , cord-010092-uftc8inx 700 13 c c NNP cord-010092-uftc8inx 700 14 , , , cord-010092-uftc8inx 700 15 E E NNP cord-010092-uftc8inx 700 16 , , , cord-010092-uftc8inx 700 17 e e NN cord-010092-uftc8inx 700 18 and and CC cord-010092-uftc8inx 700 19 K K NNP cord-010092-uftc8inx 700 20 , , , cord-010092-uftc8inx 700 21 patients patient NNS cord-010092-uftc8inx 700 22 with with IN cord-010092-uftc8inx 700 23 SCD SCD NNP cord-010092-uftc8inx 700 24 and and CC cord-010092-uftc8inx 700 25 TDT TDT NNP cord-010092-uftc8inx 700 26 should should MD cord-010092-uftc8inx 700 27 ideally ideally RB cord-010092-uftc8inx 700 28 receive receive VB cord-010092-uftc8inx 700 29 RBC RBC NNP cord-010092-uftc8inx 700 30 units unit NNS cord-010092-uftc8inx 700 31 matched match VBN cord-010092-uftc8inx 700 32 also also RB cord-010092-uftc8inx 700 33 for for IN cord-010092-uftc8inx 700 34 M M NNP cord-010092-uftc8inx 700 35 , , , cord-010092-uftc8inx 700 36 S S NNP cord-010092-uftc8inx 700 37 , , , cord-010092-uftc8inx 700 38 s s NNP cord-010092-uftc8inx 700 39 , , , cord-010092-uftc8inx 700 40 Fya Fya NNP cord-010092-uftc8inx 700 41 , , , cord-010092-uftc8inx 700 42 Fyb Fyb NNP cord-010092-uftc8inx 700 43 , , , cord-010092-uftc8inx 700 44 Jka Jka NNP cord-010092-uftc8inx 700 45 and and CC cord-010092-uftc8inx 700 46 Jkb Jkb NNP cord-010092-uftc8inx 700 47 ( ( -LRB- cord-010092-uftc8inx 700 48 extended extended JJ cord-010092-uftc8inx 700 49 phenotype phenotype NN cord-010092-uftc8inx 700 50 ) ) -RRB- cord-010092-uftc8inx 700 51 . . . cord-010092-uftc8inx 701 1 This this DT cord-010092-uftc8inx 701 2 is be VBZ cord-010092-uftc8inx 701 3 the the DT cord-010092-uftc8inx 701 4 policy policy NN cord-010092-uftc8inx 701 5 at at IN cord-010092-uftc8inx 701 6 our -PRON- PRP$ cord-010092-uftc8inx 701 7 center center NN cord-010092-uftc8inx 701 8 , , , cord-010092-uftc8inx 701 9 which which WDT cord-010092-uftc8inx 701 10 currently currently RB cord-010092-uftc8inx 701 11 provides provide VBZ cord-010092-uftc8inx 701 12 RBC RBC NNP cord-010092-uftc8inx 701 13 products product NNS cord-010092-uftc8inx 701 14 to to IN cord-010092-uftc8inx 701 15 31 31 CD cord-010092-uftc8inx 701 16 patients patient NNS cord-010092-uftc8inx 701 17 with with IN cord-010092-uftc8inx 701 18 hemoglobinopathies hemoglobinopathy NNS cord-010092-uftc8inx 701 19 . . . cord-010092-uftc8inx 702 1 Because because IN cord-010092-uftc8inx 702 2 the the DT cord-010092-uftc8inx 702 3 vast vast JJ cord-010092-uftc8inx 702 4 majority majority NN cord-010092-uftc8inx 702 5 of of IN cord-010092-uftc8inx 702 6 our -PRON- PRP$ cord-010092-uftc8inx 702 7 blood blood NN cord-010092-uftc8inx 702 8 donors donor NNS cord-010092-uftc8inx 702 9 are be VBP cord-010092-uftc8inx 702 10 Caucasians Caucasians NNPS cord-010092-uftc8inx 702 11 , , , cord-010092-uftc8inx 702 12 the the DT cord-010092-uftc8inx 702 13 selection selection NN cord-010092-uftc8inx 702 14 of of IN cord-010092-uftc8inx 702 15 matched match VBN cord-010092-uftc8inx 702 16 RBC RBC NNP cord-010092-uftc8inx 702 17 units unit NNS cord-010092-uftc8inx 702 18 for for IN cord-010092-uftc8inx 702 19 patients patient NNS cord-010092-uftc8inx 702 20 of of IN cord-010092-uftc8inx 702 21 different different JJ cord-010092-uftc8inx 702 22 ethnic ethnic JJ cord-010092-uftc8inx 702 23 origin origin NN cord-010092-uftc8inx 702 24 can can MD cord-010092-uftc8inx 702 25 be be VB cord-010092-uftc8inx 702 26 difficult difficult JJ cord-010092-uftc8inx 702 27 . . . cord-010092-uftc8inx 703 1 Therefore therefore RB cord-010092-uftc8inx 703 2 , , , cord-010092-uftc8inx 703 3 expanding expand VBG cord-010092-uftc8inx 703 4 the the DT cord-010092-uftc8inx 703 5 number number NN cord-010092-uftc8inx 703 6 of of IN cord-010092-uftc8inx 703 7 available available JJ cord-010092-uftc8inx 703 8 African african JJ cord-010092-uftc8inx 703 9 and and CC cord-010092-uftc8inx 703 10 Asian asian JJ cord-010092-uftc8inx 703 11 blood blood NN cord-010092-uftc8inx 703 12 donors donor NNS cord-010092-uftc8inx 703 13 is be VBZ cord-010092-uftc8inx 703 14 becoming become VBG cord-010092-uftc8inx 703 15 increasingly increasingly RB cord-010092-uftc8inx 703 16 necessary necessary JJ cord-010092-uftc8inx 703 17 . . . cord-010092-uftc8inx 704 1 Aims aim VBZ cord-010092-uftc8inx 704 2 : : : cord-010092-uftc8inx 705 1 Hereby hereby RB cord-010092-uftc8inx 705 2 the the DT cord-010092-uftc8inx 705 3 recruitment recruitment NN cord-010092-uftc8inx 705 4 strategy strategy NN cord-010092-uftc8inx 705 5 of of IN cord-010092-uftc8inx 705 6 non non JJ cord-010092-uftc8inx 705 7 - - JJ cord-010092-uftc8inx 705 8 Caucasian caucasian JJ cord-010092-uftc8inx 705 9 blood blood NN cord-010092-uftc8inx 705 10 donors donor NNS cord-010092-uftc8inx 705 11 introduced introduce VBN cord-010092-uftc8inx 705 12 at at IN cord-010092-uftc8inx 705 13 our -PRON- PRP$ cord-010092-uftc8inx 705 14 center center NN cord-010092-uftc8inx 705 15 is be VBZ cord-010092-uftc8inx 705 16 described describe VBN cord-010092-uftc8inx 705 17 and and CC cord-010092-uftc8inx 705 18 the the DT cord-010092-uftc8inx 705 19 results result NNS cord-010092-uftc8inx 705 20 obtained obtain VBN cord-010092-uftc8inx 705 21 during during IN cord-010092-uftc8inx 705 22 six six CD cord-010092-uftc8inx 705 23 years year NNS cord-010092-uftc8inx 705 24 are be VBP cord-010092-uftc8inx 705 25 reported report VBN cord-010092-uftc8inx 705 26 . . . cord-010092-uftc8inx 706 1 Methods method NNS cord-010092-uftc8inx 706 2 : : : cord-010092-uftc8inx 706 3 Since since IN cord-010092-uftc8inx 706 4 01.01.2013 01.01.2013 CD cord-010092-uftc8inx 706 5 , , , cord-010092-uftc8inx 706 6 whenever whenever WRB cord-010092-uftc8inx 706 7 a a DT cord-010092-uftc8inx 706 8 first first JJ cord-010092-uftc8inx 706 9 - - HYPH cord-010092-uftc8inx 706 10 time time NN cord-010092-uftc8inx 706 11 blood blood NN cord-010092-uftc8inx 706 12 donor donor NN cord-010092-uftc8inx 706 13 of of IN cord-010092-uftc8inx 706 14 non non JJ cord-010092-uftc8inx 706 15 - - JJ cord-010092-uftc8inx 706 16 Caucasian caucasian JJ cord-010092-uftc8inx 706 17 origin origin NN cord-010092-uftc8inx 706 18 is be VBZ cord-010092-uftc8inx 706 19 registered register VBN cord-010092-uftc8inx 706 20 , , , cord-010092-uftc8inx 706 21 an an DT cord-010092-uftc8inx 706 22 alert alert NN cord-010092-uftc8inx 706 23 is be VBZ cord-010092-uftc8inx 706 24 entered enter VBN cord-010092-uftc8inx 706 25 in in IN cord-010092-uftc8inx 706 26 the the DT cord-010092-uftc8inx 706 27 donor donor NN cord-010092-uftc8inx 706 28 file file NN cord-010092-uftc8inx 706 29 to to TO cord-010092-uftc8inx 706 30 trigger trigger VB cord-010092-uftc8inx 706 31 the the DT cord-010092-uftc8inx 706 32 determination determination NN cord-010092-uftc8inx 706 33 of of IN cord-010092-uftc8inx 706 34 the the DT cord-010092-uftc8inx 706 35 extended extended JJ cord-010092-uftc8inx 706 36 RBC RBC NNP cord-010092-uftc8inx 706 37 phenotype phenotype NN cord-010092-uftc8inx 706 38 along along IN cord-010092-uftc8inx 706 39 with with IN cord-010092-uftc8inx 706 40 routine routine JJ cord-010092-uftc8inx 706 41 testing testing NN cord-010092-uftc8inx 706 42 . . . cord-010092-uftc8inx 707 1 RBC RBC NNP cord-010092-uftc8inx 707 2 antigen antigen NN cord-010092-uftc8inx 707 3 determination determination NN cord-010092-uftc8inx 707 4 is be VBZ cord-010092-uftc8inx 707 5 performed perform VBN cord-010092-uftc8inx 707 6 in in IN cord-010092-uftc8inx 707 7 our -PRON- PRP$ cord-010092-uftc8inx 707 8 laboratory laboratory NN cord-010092-uftc8inx 707 9 with with IN cord-010092-uftc8inx 707 10 serologic serologic JJ cord-010092-uftc8inx 707 11 methods method NNS cord-010092-uftc8inx 707 12 . . . cord-010092-uftc8inx 708 1 In in IN cord-010092-uftc8inx 708 2 selected select VBN cord-010092-uftc8inx 708 3 cases case NNS cord-010092-uftc8inx 708 4 ( ( -LRB- cord-010092-uftc8inx 708 5 i.e. i.e. FW cord-010092-uftc8inx 708 6 suspected suspect VBN cord-010092-uftc8inx 708 7 RhD rhd NN cord-010092-uftc8inx 708 8 or or CC cord-010092-uftc8inx 708 9 RhCE rhce NN cord-010092-uftc8inx 708 10 variant variant NN cord-010092-uftc8inx 708 11 ) ) -RRB- cord-010092-uftc8inx 708 12 , , , cord-010092-uftc8inx 708 13 samples sample NNS cord-010092-uftc8inx 708 14 are be VBP cord-010092-uftc8inx 708 15 sent send VBN cord-010092-uftc8inx 708 16 for for IN cord-010092-uftc8inx 708 17 molecular molecular JJ cord-010092-uftc8inx 708 18 analysis analysis NN cord-010092-uftc8inx 708 19 ( ( -LRB- cord-010092-uftc8inx 708 20 SSP SSP NNP cord-010092-uftc8inx 708 21 PCR PCR NNP cord-010092-uftc8inx 708 22 ) ) -RRB- cord-010092-uftc8inx 708 23 . . . cord-010092-uftc8inx 709 1 Rare rare JJ cord-010092-uftc8inx 709 2 RBC RBC NNP cord-010092-uftc8inx 709 3 phenotypes phenotype NNS cord-010092-uftc8inx 709 4 relative relative JJ cord-010092-uftc8inx 709 5 to to IN cord-010092-uftc8inx 709 6 ethnicity ethnicity NN cord-010092-uftc8inx 709 7 are be VBP cord-010092-uftc8inx 709 8 , , , cord-010092-uftc8inx 709 9 among among IN cord-010092-uftc8inx 709 10 others other NNS cord-010092-uftc8inx 709 11 , , , cord-010092-uftc8inx 709 12 Fy(a Fy(a NNP cord-010092-uftc8inx 709 13 - - HYPH cord-010092-uftc8inx 709 14 b- b- NNP cord-010092-uftc8inx 709 15 ) ) -RRB- cord-010092-uftc8inx 709 16 , , , cord-010092-uftc8inx 709 17 S s NN cord-010092-uftc8inx 709 18 - - HYPH cord-010092-uftc8inx 709 19 s- s- XX cord-010092-uftc8inx 709 20 , , , cord-010092-uftc8inx 709 21 Lu(b- Lu(b- '' cord-010092-uftc8inx 709 22 ) ) -RRB- cord-010092-uftc8inx 709 23 and and CC cord-010092-uftc8inx 709 24 those those DT cord-010092-uftc8inx 709 25 with with IN cord-010092-uftc8inx 709 26 uncommon uncommon JJ cord-010092-uftc8inx 709 27 Rh Rh NNP cord-010092-uftc8inx 709 28 phenotypes phenotype NNS cord-010092-uftc8inx 709 29 . . . cord-010092-uftc8inx 710 1 If if IN cord-010092-uftc8inx 710 2 a a DT cord-010092-uftc8inx 710 3 rare rare JJ cord-010092-uftc8inx 710 4 RBC RBC NNP cord-010092-uftc8inx 710 5 phenotype phenotype NN cord-010092-uftc8inx 710 6 is be VBZ cord-010092-uftc8inx 710 7 detected detect VBN cord-010092-uftc8inx 710 8 , , , cord-010092-uftc8inx 710 9 a a DT cord-010092-uftc8inx 710 10 coded code VBN cord-010092-uftc8inx 710 11 comment comment NN cord-010092-uftc8inx 710 12 is be VBZ cord-010092-uftc8inx 710 13 entered enter VBN cord-010092-uftc8inx 710 14 in in IN cord-010092-uftc8inx 710 15 the the DT cord-010092-uftc8inx 710 16 donor donor NN cord-010092-uftc8inx 710 17 data datum NNS cord-010092-uftc8inx 710 18 and and CC cord-010092-uftc8inx 710 19 the the DT cord-010092-uftc8inx 710 20 donor donor NN cord-010092-uftc8inx 710 21 is be VBZ cord-010092-uftc8inx 710 22 listed list VBN cord-010092-uftc8inx 710 23 in in IN cord-010092-uftc8inx 710 24 the the DT cord-010092-uftc8inx 710 25 national national JJ cord-010092-uftc8inx 710 26 Rare Rare NNP cord-010092-uftc8inx 710 27 Donor Donor NNP cord-010092-uftc8inx 710 28 File File NNP cord-010092-uftc8inx 710 29 . . . cord-010092-uftc8inx 711 1 Results result NNS cord-010092-uftc8inx 711 2 : : : cord-010092-uftc8inx 712 1 From from IN cord-010092-uftc8inx 712 2 01.01.2013 01.01.2013 CD cord-010092-uftc8inx 712 3 until until IN cord-010092-uftc8inx 712 4 01.03.2019 01.03.2019 NNP cord-010092-uftc8inx 712 5 , , , cord-010092-uftc8inx 712 6 an an DT cord-010092-uftc8inx 712 7 extended extended JJ cord-010092-uftc8inx 712 8 determination determination NN cord-010092-uftc8inx 712 9 of of IN cord-010092-uftc8inx 712 10 RBC RBC NNP cord-010092-uftc8inx 712 11 antigens antigen NNS cord-010092-uftc8inx 712 12 was be VBD cord-010092-uftc8inx 712 13 performed perform VBN cord-010092-uftc8inx 712 14 in in IN cord-010092-uftc8inx 712 15 352 352 CD cord-010092-uftc8inx 712 16 subjects subject NNS cord-010092-uftc8inx 712 17 presenting present VBG cord-010092-uftc8inx 712 18 for for IN cord-010092-uftc8inx 712 19 blood blood NN cord-010092-uftc8inx 712 20 donation donation NN cord-010092-uftc8inx 712 21 . . . cord-010092-uftc8inx 713 1 Twenty twenty CD cord-010092-uftc8inx 713 2 - - HYPH cord-010092-uftc8inx 713 3 nine nine CD cord-010092-uftc8inx 713 4 rare rare JJ cord-010092-uftc8inx 713 5 donors donor NNS cord-010092-uftc8inx 713 6 ( ( -LRB- cord-010092-uftc8inx 713 7 8 8 CD cord-010092-uftc8inx 713 8 % % NN cord-010092-uftc8inx 713 9 ) ) -RRB- cord-010092-uftc8inx 713 10 were be VBD cord-010092-uftc8inx 713 11 identified identify VBN cord-010092-uftc8inx 713 12 and and CC cord-010092-uftc8inx 713 13 included include VBN cord-010092-uftc8inx 713 14 in in IN cord-010092-uftc8inx 713 15 the the DT cord-010092-uftc8inx 713 16 Rare Rare NNP cord-010092-uftc8inx 713 17 Donor Donor NNP cord-010092-uftc8inx 713 18 File file NN cord-010092-uftc8inx 713 19 : : : cord-010092-uftc8inx 713 20 25 25 CD cord-010092-uftc8inx 713 21 Fy(a Fy(a NNP cord-010092-uftc8inx 713 22 - - HYPH cord-010092-uftc8inx 713 23 b- b- NNP cord-010092-uftc8inx 713 24 ) ) -RRB- cord-010092-uftc8inx 713 25 , , , cord-010092-uftc8inx 713 26 1 1 CD cord-010092-uftc8inx 713 27 Lu Lu NNP cord-010092-uftc8inx 713 28 ( ( -LRB- cord-010092-uftc8inx 713 29 a a RB cord-010092-uftc8inx 713 30 - - HYPH cord-010092-uftc8inx 713 31 b- b- NN cord-010092-uftc8inx 713 32 ) ) -RRB- cord-010092-uftc8inx 713 33 , , , cord-010092-uftc8inx 713 34 1 1 CD cord-010092-uftc8inx 713 35 Lu(b- lu(b- CD cord-010092-uftc8inx 713 36 ) ) -RRB- cord-010092-uftc8inx 713 37 , , , cord-010092-uftc8inx 713 38 1 1 CD cord-010092-uftc8inx 713 39 Fy(a Fy(a NNP cord-010092-uftc8inx 713 40 - - HYPH cord-010092-uftc8inx 713 41 b- b- NNP cord-010092-uftc8inx 713 42 ) ) -RRB- cord-010092-uftc8inx 713 43 and and CC cord-010092-uftc8inx 713 44 S- S- NNP cord-010092-uftc8inx 713 45 , , , cord-010092-uftc8inx 713 46 1 1 CD cord-010092-uftc8inx 713 47 CCddee CCddee NNPS cord-010092-uftc8inx 713 48 ( ( -LRB- cord-010092-uftc8inx 713 49 r'r r'r NNP cord-010092-uftc8inx 713 50 ' ' '' cord-010092-uftc8inx 713 51 ) ) -RRB- cord-010092-uftc8inx 713 52 . . . cord-010092-uftc8inx 714 1 Overall overall RB cord-010092-uftc8inx 714 2 , , , cord-010092-uftc8inx 714 3 these these DT cord-010092-uftc8inx 714 4 29 29 CD cord-010092-uftc8inx 714 5 donors donor NNS cord-010092-uftc8inx 714 6 provided provide VBD cord-010092-uftc8inx 714 7 105 105 CD cord-010092-uftc8inx 714 8 RBC RBC NNP cord-010092-uftc8inx 714 9 units unit NNS cord-010092-uftc8inx 714 10 ( ( -LRB- cord-010092-uftc8inx 714 11 range range NN cord-010092-uftc8inx 714 12 . . . cord-010092-uftc8inx 715 1 To to IN cord-010092-uftc8inx 715 2 date date NN cord-010092-uftc8inx 715 3 , , , cord-010092-uftc8inx 715 4 all all DT cord-010092-uftc8inx 715 5 donors donor NNS cord-010092-uftc8inx 715 6 are be VBP cord-010092-uftc8inx 715 7 still still RB cord-010092-uftc8inx 715 8 active active JJ cord-010092-uftc8inx 715 9 and and CC cord-010092-uftc8inx 715 10 14 14 CD cord-010092-uftc8inx 715 11 are be VBP cord-010092-uftc8inx 715 12 reserved reserve VBN cord-010092-uftc8inx 715 13 for for IN cord-010092-uftc8inx 715 14 dedicated dedicated JJ cord-010092-uftc8inx 715 15 donations donation NNS cord-010092-uftc8inx 715 16 . . . cord-010092-uftc8inx 716 1 The the DT cord-010092-uftc8inx 716 2 internal internal JJ cord-010092-uftc8inx 716 3 price price NN cord-010092-uftc8inx 716 4 of of IN cord-010092-uftc8inx 716 5 RBC RBC NNP cord-010092-uftc8inx 716 6 antigen antigen NN cord-010092-uftc8inx 716 7 testing testing NN cord-010092-uftc8inx 716 8 per per IN cord-010092-uftc8inx 716 9 donor donor NN cord-010092-uftc8inx 716 10 is be VBZ cord-010092-uftc8inx 716 11 approximately approximately RB cord-010092-uftc8inx 716 12 100 100 CD cord-010092-uftc8inx 716 13 . . . cord-010092-uftc8inx 717 1 -CHF -chf RB cord-010092-uftc8inx 717 2 , , , cord-010092-uftc8inx 717 3 resulting result VBG cord-010092-uftc8inx 717 4 in in IN cord-010092-uftc8inx 717 5 a a DT cord-010092-uftc8inx 717 6 total total JJ cord-010092-uftc8inx 717 7 financial financial JJ cord-010092-uftc8inx 717 8 effort effort NN cord-010092-uftc8inx 717 9 of of IN cord-010092-uftc8inx 717 10 around around IN cord-010092-uftc8inx 717 11 35,200.-CHF 35,200.-chf CD cord-010092-uftc8inx 717 12 in in IN cord-010092-uftc8inx 717 13 the the DT cord-010092-uftc8inx 717 14 time time NN cord-010092-uftc8inx 717 15 since since IN cord-010092-uftc8inx 717 16 the the DT cord-010092-uftc8inx 717 17 project project NN cord-010092-uftc8inx 717 18 was be VBD cord-010092-uftc8inx 717 19 started start VBN cord-010092-uftc8inx 717 20 . . . cord-010092-uftc8inx 718 1 Summary Summary NNP cord-010092-uftc8inx 718 2 / / SYM cord-010092-uftc8inx 718 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 718 4 : : : cord-010092-uftc8inx 719 1 In in IN cord-010092-uftc8inx 719 2 our -PRON- PRP$ cord-010092-uftc8inx 719 3 experience experience NN cord-010092-uftc8inx 719 4 , , , cord-010092-uftc8inx 719 5 a a DT cord-010092-uftc8inx 719 6 " " `` cord-010092-uftc8inx 719 7 passive passive JJ cord-010092-uftc8inx 719 8 " " '' cord-010092-uftc8inx 719 9 recruitment recruitment NN cord-010092-uftc8inx 719 10 of of IN cord-010092-uftc8inx 719 11 non non JJ cord-010092-uftc8inx 719 12 - - JJ cord-010092-uftc8inx 719 13 Caucasian caucasian JJ cord-010092-uftc8inx 719 14 blood blood NN cord-010092-uftc8inx 719 15 donors donor NNS cord-010092-uftc8inx 719 16 based base VBN cord-010092-uftc8inx 719 17 on on IN cord-010092-uftc8inx 719 18 ethnicity ethnicity NN cord-010092-uftc8inx 719 19 has have VBZ cord-010092-uftc8inx 719 20 an an DT cord-010092-uftc8inx 719 21 overall overall JJ cord-010092-uftc8inx 719 22 low low JJ cord-010092-uftc8inx 719 23 efficiency efficiency NN cord-010092-uftc8inx 719 24 from from IN cord-010092-uftc8inx 719 25 a a DT cord-010092-uftc8inx 719 26 logistic logistic JJ cord-010092-uftc8inx 719 27 and and CC cord-010092-uftc8inx 719 28 financial financial JJ cord-010092-uftc8inx 719 29 point point NN cord-010092-uftc8inx 719 30 of of IN cord-010092-uftc8inx 719 31 view view NN cord-010092-uftc8inx 719 32 . . . cord-010092-uftc8inx 720 1 Moreover moreover RB cord-010092-uftc8inx 720 2 , , , cord-010092-uftc8inx 720 3 African african JJ cord-010092-uftc8inx 720 4 and and CC cord-010092-uftc8inx 720 5 Asian asian JJ cord-010092-uftc8inx 720 6 blood blood NN cord-010092-uftc8inx 720 7 donors donor NNS cord-010092-uftc8inx 720 8 may may MD cord-010092-uftc8inx 720 9 require require VB cord-010092-uftc8inx 720 10 investigations investigation NNS cord-010092-uftc8inx 720 11 for for IN cord-010092-uftc8inx 720 12 hemoglobin hemoglobin NN cord-010092-uftc8inx 720 13 variants variant NNS cord-010092-uftc8inx 720 14 and and CC cord-010092-uftc8inx 720 15 serology serology NN cord-010092-uftc8inx 720 16 for for IN cord-010092-uftc8inx 720 17 malaria malaria NN cord-010092-uftc8inx 720 18 in in IN cord-010092-uftc8inx 720 19 addition addition NN cord-010092-uftc8inx 720 20 to to IN cord-010092-uftc8inx 720 21 routine routine JJ cord-010092-uftc8inx 720 22 testing testing NN cord-010092-uftc8inx 720 23 . . . cord-010092-uftc8inx 721 1 Nevertheless nevertheless RB cord-010092-uftc8inx 721 2 , , , cord-010092-uftc8inx 721 3 a a DT cord-010092-uftc8inx 721 4 targeted target VBN cord-010092-uftc8inx 721 5 determination determination NN cord-010092-uftc8inx 721 6 of of IN cord-010092-uftc8inx 721 7 extended extend VBN cord-010092-uftc8inx 721 8 RBC RBC NNP cord-010092-uftc8inx 721 9 antigen antigen NN cord-010092-uftc8inx 721 10 phenotype phenotype NN cord-010092-uftc8inx 721 11 does do VBZ cord-010092-uftc8inx 721 12 allow allow VB cord-010092-uftc8inx 721 13 the the DT cord-010092-uftc8inx 721 14 identification identification NN cord-010092-uftc8inx 721 15 of of IN cord-010092-uftc8inx 721 16 persons person NNS cord-010092-uftc8inx 721 17 with with IN cord-010092-uftc8inx 721 18 rare rare JJ cord-010092-uftc8inx 721 19 phenotypes phenotype NNS cord-010092-uftc8inx 721 20 . . . cord-010092-uftc8inx 722 1 Currently currently RB cord-010092-uftc8inx 722 2 , , , cord-010092-uftc8inx 722 3 measures measure NNS cord-010092-uftc8inx 722 4 for for IN cord-010092-uftc8inx 722 5 the the DT cord-010092-uftc8inx 722 6 active active JJ cord-010092-uftc8inx 722 7 recruitment recruitment NN cord-010092-uftc8inx 722 8 of of IN cord-010092-uftc8inx 722 9 potentially potentially RB cord-010092-uftc8inx 722 10 rare rare JJ cord-010092-uftc8inx 722 11 blood blood NN cord-010092-uftc8inx 722 12 donors donor NNS cord-010092-uftc8inx 722 13 are be VBP cord-010092-uftc8inx 722 14 being be VBG cord-010092-uftc8inx 722 15 implemented implement VBN cord-010092-uftc8inx 722 16 at at IN cord-010092-uftc8inx 722 17 our -PRON- PRP$ cord-010092-uftc8inx 722 18 center center NN cord-010092-uftc8inx 722 19 . . . cord-010092-uftc8inx 723 1 After after IN cord-010092-uftc8inx 723 2 a a DT cord-010092-uftc8inx 723 3 pilot pilot NN cord-010092-uftc8inx 723 4 phase phase NN cord-010092-uftc8inx 723 5 , , , cord-010092-uftc8inx 723 6 a a DT cord-010092-uftc8inx 723 7 project project NN cord-010092-uftc8inx 723 8 for for IN cord-010092-uftc8inx 723 9 a a DT cord-010092-uftc8inx 723 10 nationwide nationwide JJ cord-010092-uftc8inx 723 11 recruitment recruitment NN cord-010092-uftc8inx 723 12 strategy strategy NN cord-010092-uftc8inx 723 13 will will MD cord-010092-uftc8inx 723 14 be be VB cord-010092-uftc8inx 723 15 elaborated elaborate VBN cord-010092-uftc8inx 723 16 . . . cord-010092-uftc8inx 724 1 A a DT cord-010092-uftc8inx 724 2 further further JJ cord-010092-uftc8inx 724 3 goal goal NN cord-010092-uftc8inx 724 4 is be VBZ cord-010092-uftc8inx 724 5 to to TO cord-010092-uftc8inx 724 6 build build VB cord-010092-uftc8inx 724 7 a a DT cord-010092-uftc8inx 724 8 national national JJ cord-010092-uftc8inx 724 9 registry registry NN cord-010092-uftc8inx 724 10 of of IN cord-010092-uftc8inx 724 11 patients patient NNS cord-010092-uftc8inx 724 12 with with IN cord-010092-uftc8inx 724 13 hemoglobinopathies hemoglobinopathy NNS cord-010092-uftc8inx 724 14 requiring require VBG cord-010092-uftc8inx 724 15 transfusions transfusion NNS cord-010092-uftc8inx 724 16 . . . cord-010092-uftc8inx 725 1 Blood blood NN cord-010092-uftc8inx 725 2 transfusion transfusion NN cord-010092-uftc8inx 725 3 is be VBZ cord-010092-uftc8inx 725 4 an an DT cord-010092-uftc8inx 725 5 essential essential JJ cord-010092-uftc8inx 725 6 treatment treatment NN cord-010092-uftc8inx 725 7 . . . cord-010092-uftc8inx 726 1 Transfusion transfusion NN cord-010092-uftc8inx 726 2 safety safety NN cord-010092-uftc8inx 726 3 consists consist VBZ cord-010092-uftc8inx 726 4 of of IN cord-010092-uftc8inx 726 5 several several JJ cord-010092-uftc8inx 726 6 components component NNS cord-010092-uftc8inx 726 7 . . . cord-010092-uftc8inx 727 1 Although although IN cord-010092-uftc8inx 727 2 all all DT cord-010092-uftc8inx 727 3 are be VBP cord-010092-uftc8inx 727 4 important important JJ cord-010092-uftc8inx 727 5 , , , cord-010092-uftc8inx 727 6 ion ion NN cord-010092-uftc8inx 727 7 richer rich JJR cord-010092-uftc8inx 727 8 countries country NNS cord-010092-uftc8inx 728 1 the the DT cord-010092-uftc8inx 728 2 order order NN cord-010092-uftc8inx 728 3 of of IN cord-010092-uftc8inx 728 4 priority priority NN cord-010092-uftc8inx 728 5 is be VBZ cord-010092-uftc8inx 728 6 typically typically RB cord-010092-uftc8inx 728 7 : : : cord-010092-uftc8inx 728 8 1 1 LS cord-010092-uftc8inx 728 9 . . . cord-010092-uftc8inx 728 10 ) ) -RRB- cord-010092-uftc8inx 729 1 Avoidance avoidance NN cord-010092-uftc8inx 729 2 of of IN cord-010092-uftc8inx 729 3 transfusion transfusion NN cord-010092-uftc8inx 729 4 transmittable transmittable JJ cord-010092-uftc8inx 729 5 infections infection NNS cord-010092-uftc8inx 729 6 ; ; : cord-010092-uftc8inx 729 7 2 2 CD cord-010092-uftc8inx 729 8 . . . cord-010092-uftc8inx 729 9 ) ) -RRB- cord-010092-uftc8inx 730 1 Quality quality NN cord-010092-uftc8inx 730 2 of of IN cord-010092-uftc8inx 730 3 the the DT cord-010092-uftc8inx 730 4 blood blood NN cord-010092-uftc8inx 730 5 product product NN cord-010092-uftc8inx 730 6 with with IN cord-010092-uftc8inx 730 7 a a DT cord-010092-uftc8inx 730 8 strong strong JJ cord-010092-uftc8inx 730 9 focus focus NN cord-010092-uftc8inx 730 10 on on IN cord-010092-uftc8inx 730 11 component component NN cord-010092-uftc8inx 730 12 therapy therapy NN cord-010092-uftc8inx 730 13 ; ; : cord-010092-uftc8inx 730 14 3 3 CD cord-010092-uftc8inx 730 15 . . . cord-010092-uftc8inx 730 16 ) ) -RRB- cord-010092-uftc8inx 731 1 Prevention prevention NN cord-010092-uftc8inx 731 2 of of IN cord-010092-uftc8inx 731 3 severe severe JJ cord-010092-uftc8inx 731 4 transfusion transfusion NN cord-010092-uftc8inx 731 5 reactions reaction NNS cord-010092-uftc8inx 731 6 ; ; : cord-010092-uftc8inx 731 7 4 4 CD cord-010092-uftc8inx 731 8 . . . cord-010092-uftc8inx 731 9 ) ) -RRB- cord-010092-uftc8inx 732 1 Avoidance avoidance NN cord-010092-uftc8inx 732 2 of of IN cord-010092-uftc8inx 732 3 clerical clerical JJ cord-010092-uftc8inx 732 4 errors error NNS cord-010092-uftc8inx 732 5 ; ; : cord-010092-uftc8inx 732 6 3 3 CD cord-010092-uftc8inx 732 7 . . . cord-010092-uftc8inx 732 8 ) ) -RRB- cord-010092-uftc8inx 733 1 Sufficient sufficient JJ cord-010092-uftc8inx 733 2 availability availability NN cord-010092-uftc8inx 733 3 of of IN cord-010092-uftc8inx 733 4 blood blood NN cord-010092-uftc8inx 733 5 . . . cord-010092-uftc8inx 734 1 The the DT cord-010092-uftc8inx 734 2 keynote keynote NN cord-010092-uftc8inx 734 3 of of IN cord-010092-uftc8inx 734 4 this this DT cord-010092-uftc8inx 734 5 lecture lecture NN cord-010092-uftc8inx 734 6 will will MD cord-010092-uftc8inx 734 7 be be VB cord-010092-uftc8inx 734 8 that that IN cord-010092-uftc8inx 734 9 the the DT cord-010092-uftc8inx 734 10 order order NN cord-010092-uftc8inx 734 11 of of IN cord-010092-uftc8inx 734 12 priorities priority NNS cord-010092-uftc8inx 734 13 on on IN cord-010092-uftc8inx 734 14 transfusion transfusion NN cord-010092-uftc8inx 734 15 safety safety NN cord-010092-uftc8inx 734 16 should should MD cord-010092-uftc8inx 734 17 probably probably RB cord-010092-uftc8inx 734 18 be be VB cord-010092-uftc8inx 734 19 different different JJ cord-010092-uftc8inx 734 20 in in IN cord-010092-uftc8inx 734 21 resource resource NN cord-010092-uftc8inx 734 22 limited limit VBN cord-010092-uftc8inx 734 23 environments environment NNS cord-010092-uftc8inx 734 24 . . . cord-010092-uftc8inx 735 1 1 1 LS cord-010092-uftc8inx 735 2 . . . cord-010092-uftc8inx 735 3 ) ) -RRB- cord-010092-uftc8inx 736 1 Sufficient sufficient JJ cord-010092-uftc8inx 736 2 availability availability NN cord-010092-uftc8inx 736 3 of of IN cord-010092-uftc8inx 736 4 blood blood NN cord-010092-uftc8inx 736 5 and and CC cord-010092-uftc8inx 736 6 proper proper JJ cord-010092-uftc8inx 736 7 utilisation utilisation NN cord-010092-uftc8inx 736 8 ; ; : cord-010092-uftc8inx 736 9 2 2 CD cord-010092-uftc8inx 736 10 . . . cord-010092-uftc8inx 736 11 ) ) -RRB- cord-010092-uftc8inx 737 1 Avoidance avoidance NN cord-010092-uftc8inx 737 2 of of IN cord-010092-uftc8inx 737 3 transfusion transfusion NN cord-010092-uftc8inx 737 4 transmittable transmittable JJ cord-010092-uftc8inx 737 5 infections infection NNS cord-010092-uftc8inx 737 6 ; ; : cord-010092-uftc8inx 737 7 3 3 CD cord-010092-uftc8inx 737 8 . . . cord-010092-uftc8inx 737 9 ) ) -RRB- cord-010092-uftc8inx 738 1 Avoidance avoidance NN cord-010092-uftc8inx 738 2 of of IN cord-010092-uftc8inx 738 3 clerical clerical JJ cord-010092-uftc8inx 738 4 errors error NNS cord-010092-uftc8inx 738 5 ; ; : cord-010092-uftc8inx 738 6 4 4 CD cord-010092-uftc8inx 738 7 . . . cord-010092-uftc8inx 738 8 ) ) -RRB- cord-010092-uftc8inx 739 1 Prevention prevention NN cord-010092-uftc8inx 739 2 of of IN cord-010092-uftc8inx 739 3 severe severe JJ cord-010092-uftc8inx 739 4 transfusion transfusion NN cord-010092-uftc8inx 739 5 reactions reaction NNS cord-010092-uftc8inx 739 6 ; ; : cord-010092-uftc8inx 739 7 5 5 CD cord-010092-uftc8inx 739 8 . . . cord-010092-uftc8inx 739 9 ) ) -RRB- cord-010092-uftc8inx 740 1 Quality quality NN cord-010092-uftc8inx 740 2 of of IN cord-010092-uftc8inx 740 3 the the DT cord-010092-uftc8inx 740 4 blood blood NN cord-010092-uftc8inx 740 5 product product NN cord-010092-uftc8inx 740 6 . . . cord-010092-uftc8inx 741 1 Most most RBS cord-010092-uftc8inx 741 2 important important JJ cord-010092-uftc8inx 741 3 , , , cord-010092-uftc8inx 741 4 in in IN cord-010092-uftc8inx 741 5 regions region NNS cord-010092-uftc8inx 741 6 with with IN cord-010092-uftc8inx 741 7 limited limited JJ cord-010092-uftc8inx 741 8 resources resource NNS cord-010092-uftc8inx 741 9 patients patient NNS cord-010092-uftc8inx 741 10 suffer suffer VBP cord-010092-uftc8inx 741 11 from from IN cord-010092-uftc8inx 741 12 under under IN cord-010092-uftc8inx 741 13 - - HYPH cord-010092-uftc8inx 741 14 transfusion transfusion NN cord-010092-uftc8inx 741 15 because because IN cord-010092-uftc8inx 741 16 not not RB cord-010092-uftc8inx 741 17 enough enough JJ cord-010092-uftc8inx 741 18 blood blood NN cord-010092-uftc8inx 741 19 is be VBZ cord-010092-uftc8inx 741 20 available available JJ cord-010092-uftc8inx 741 21 . . . cord-010092-uftc8inx 742 1 All all DT cord-010092-uftc8inx 742 2 efforts effort NNS cord-010092-uftc8inx 742 3 should should MD cord-010092-uftc8inx 742 4 be be VB cord-010092-uftc8inx 742 5 made make VBN cord-010092-uftc8inx 742 6 to to TO cord-010092-uftc8inx 742 7 reduce reduce VB cord-010092-uftc8inx 742 8 wastage wastage NN cord-010092-uftc8inx 742 9 of of IN cord-010092-uftc8inx 742 10 the the DT cord-010092-uftc8inx 742 11 available available JJ cord-010092-uftc8inx 742 12 blood blood NN cord-010092-uftc8inx 742 13 either either CC cord-010092-uftc8inx 742 14 by by IN cord-010092-uftc8inx 742 15 inappropriate inappropriate JJ cord-010092-uftc8inx 742 16 storage storage NN cord-010092-uftc8inx 742 17 , , , cord-010092-uftc8inx 742 18 handling handling NN cord-010092-uftc8inx 742 19 , , , cord-010092-uftc8inx 742 20 or or CC cord-010092-uftc8inx 742 21 nonindicated nonindicated JJ cord-010092-uftc8inx 742 22 transfusions transfusion NNS cord-010092-uftc8inx 742 23 . . . cord-010092-uftc8inx 743 1 In in IN cord-010092-uftc8inx 743 2 addition addition NN cord-010092-uftc8inx 743 3 , , , cord-010092-uftc8inx 743 4 prevalence prevalence NN cord-010092-uftc8inx 743 5 and and CC cord-010092-uftc8inx 743 6 number number NN cord-010092-uftc8inx 743 7 of of IN cord-010092-uftc8inx 743 8 pathogens pathogen NNS cord-010092-uftc8inx 743 9 transmittable transmittable JJ cord-010092-uftc8inx 743 10 by by IN cord-010092-uftc8inx 743 11 transfusion transfusion NN cord-010092-uftc8inx 743 12 is be VBZ cord-010092-uftc8inx 743 13 much much RB cord-010092-uftc8inx 743 14 higher high JJR cord-010092-uftc8inx 743 15 than than IN cord-010092-uftc8inx 743 16 in in IN cord-010092-uftc8inx 743 17 the the DT cord-010092-uftc8inx 743 18 richer rich JJR cord-010092-uftc8inx 743 19 parts part NNS cord-010092-uftc8inx 743 20 of of IN cord-010092-uftc8inx 743 21 the the DT cord-010092-uftc8inx 743 22 world world NN cord-010092-uftc8inx 743 23 . . . cord-010092-uftc8inx 744 1 This this DT cord-010092-uftc8inx 744 2 is be VBZ cord-010092-uftc8inx 744 3 aggravated aggravate VBN cord-010092-uftc8inx 744 4 by by IN cord-010092-uftc8inx 744 5 the the DT cord-010092-uftc8inx 744 6 fact fact NN cord-010092-uftc8inx 744 7 that that IN cord-010092-uftc8inx 744 8 rejection rejection NN cord-010092-uftc8inx 744 9 of of IN cord-010092-uftc8inx 744 10 blood blood NN cord-010092-uftc8inx 744 11 donors donor NNS cord-010092-uftc8inx 744 12 based base VBN cord-010092-uftc8inx 744 13 on on IN cord-010092-uftc8inx 744 14 their -PRON- PRP$ cord-010092-uftc8inx 744 15 history history NN cord-010092-uftc8inx 744 16 is be VBZ cord-010092-uftc8inx 744 17 problematic problematic JJ cord-010092-uftc8inx 744 18 when when WRB cord-010092-uftc8inx 744 19 the the DT cord-010092-uftc8inx 744 20 blood blood NN cord-010092-uftc8inx 744 21 bank bank NN cord-010092-uftc8inx 744 22 is be VBZ cord-010092-uftc8inx 744 23 empty empty JJ cord-010092-uftc8inx 744 24 . . . cord-010092-uftc8inx 745 1 The the DT cord-010092-uftc8inx 745 2 aim aim NN cord-010092-uftc8inx 745 3 to to TO cord-010092-uftc8inx 745 4 develop develop VB cord-010092-uftc8inx 745 5 centralized centralized JJ cord-010092-uftc8inx 745 6 national national JJ cord-010092-uftc8inx 745 7 blood blood NN cord-010092-uftc8inx 745 8 services service NNS cord-010092-uftc8inx 745 9 with with IN cord-010092-uftc8inx 745 10 few few JJ cord-010092-uftc8inx 745 11 sites site NNS cord-010092-uftc8inx 745 12 manufacturing manufacturing NN cord-010092-uftc8inx 745 13 cost cost NN cord-010092-uftc8inx 745 14 effective effective JJ cord-010092-uftc8inx 745 15 ( ( -LRB- cord-010092-uftc8inx 745 16 low low JJ cord-010092-uftc8inx 745 17 personnel personnel NNS cord-010092-uftc8inx 745 18 costs cost NNS cord-010092-uftc8inx 745 19 ) ) -RRB- cord-010092-uftc8inx 745 20 high high JJ cord-010092-uftc8inx 745 21 - - HYPH cord-010092-uftc8inx 745 22 quality quality NN cord-010092-uftc8inx 745 23 blood blood NN cord-010092-uftc8inx 745 24 products product NNS cord-010092-uftc8inx 745 25 , , , cord-010092-uftc8inx 745 26 which which WDT cord-010092-uftc8inx 745 27 are be VBP cord-010092-uftc8inx 745 28 distributed distribute VBN cord-010092-uftc8inx 745 29 to to IN cord-010092-uftc8inx 745 30 regional regional JJ cord-010092-uftc8inx 745 31 hospitals hospital NNS cord-010092-uftc8inx 745 32 is be VBZ cord-010092-uftc8inx 745 33 not not RB cord-010092-uftc8inx 745 34 matching match VBG cord-010092-uftc8inx 745 35 the the DT cord-010092-uftc8inx 745 36 reality reality NN cord-010092-uftc8inx 745 37 of of IN cord-010092-uftc8inx 745 38 infrastructure infrastructure NN cord-010092-uftc8inx 745 39 , , , cord-010092-uftc8inx 745 40 governmental governmental JJ cord-010092-uftc8inx 745 41 support support NN cord-010092-uftc8inx 745 42 , , , cord-010092-uftc8inx 745 43 and and CC cord-010092-uftc8inx 745 44 functionality functionality NN cord-010092-uftc8inx 745 45 . . . cord-010092-uftc8inx 746 1 In in IN cord-010092-uftc8inx 746 2 healthcare healthcare NN cord-010092-uftc8inx 746 3 systems system NNS cord-010092-uftc8inx 746 4 with with IN cord-010092-uftc8inx 746 5 limited limited JJ cord-010092-uftc8inx 746 6 resources resource NNS cord-010092-uftc8inx 746 7 usually usually RB cord-010092-uftc8inx 746 8 available available JJ cord-010092-uftc8inx 746 9 personnel personnel NNS cord-010092-uftc8inx 746 10 ( ( -LRB- cord-010092-uftc8inx 746 11 hands hand NNS cord-010092-uftc8inx 746 12 ) ) -RRB- cord-010092-uftc8inx 746 13 is be VBZ cord-010092-uftc8inx 746 14 not not RB cord-010092-uftc8inx 746 15 a a DT cord-010092-uftc8inx 746 16 problem problem NN cord-010092-uftc8inx 746 17 , , , cord-010092-uftc8inx 746 18 while while IN cord-010092-uftc8inx 746 19 reagents reagent NNS cord-010092-uftc8inx 746 20 , , , cord-010092-uftc8inx 746 21 equipment equipment NN cord-010092-uftc8inx 746 22 and and CC cord-010092-uftc8inx 746 23 even even RB cord-010092-uftc8inx 746 24 electricity electricity NN cord-010092-uftc8inx 746 25 are be VBP cord-010092-uftc8inx 746 26 precious precious JJ cord-010092-uftc8inx 746 27 resources resource NNS cord-010092-uftc8inx 746 28 . . . cord-010092-uftc8inx 747 1 The the DT cord-010092-uftc8inx 747 2 lecture lecture NN cord-010092-uftc8inx 747 3 will will MD cord-010092-uftc8inx 747 4 propose propose VB cord-010092-uftc8inx 747 5 to to TO cord-010092-uftc8inx 747 6 focus focus VB cord-010092-uftc8inx 747 7 on on IN cord-010092-uftc8inx 747 8 staff staff NN cord-010092-uftc8inx 747 9 training training NN cord-010092-uftc8inx 747 10 and and CC cord-010092-uftc8inx 747 11 education education NN cord-010092-uftc8inx 747 12 , , , cord-010092-uftc8inx 747 13 establishing establish VBG cord-010092-uftc8inx 747 14 local local JJ cord-010092-uftc8inx 747 15 hospital hospital NN cord-010092-uftc8inx 747 16 - - HYPH cord-010092-uftc8inx 747 17 based base VBN cord-010092-uftc8inx 747 18 transfusion transfusion NN cord-010092-uftc8inx 747 19 services service NNS cord-010092-uftc8inx 747 20 , , , cord-010092-uftc8inx 747 21 which which WDT cord-010092-uftc8inx 747 22 provide provide VBP cord-010092-uftc8inx 747 23 the the DT cord-010092-uftc8inx 747 24 blood blood NN cord-010092-uftc8inx 747 25 products product NNS cord-010092-uftc8inx 747 26 for for IN cord-010092-uftc8inx 747 27 the the DT cord-010092-uftc8inx 747 28 region region NN cord-010092-uftc8inx 747 29 , , , cord-010092-uftc8inx 747 30 based base VBN cord-010092-uftc8inx 747 31 on on IN cord-010092-uftc8inx 747 32 donor donor NN cord-010092-uftc8inx 747 33 recruitment recruitment NN cord-010092-uftc8inx 747 34 campaigns campaign NNS cord-010092-uftc8inx 747 35 adjusted adjust VBN cord-010092-uftc8inx 747 36 to to IN cord-010092-uftc8inx 747 37 the the DT cord-010092-uftc8inx 747 38 available available JJ cord-010092-uftc8inx 747 39 technology technology NN cord-010092-uftc8inx 747 40 , , , cord-010092-uftc8inx 747 41 local local JJ cord-010092-uftc8inx 747 42 culture culture NN cord-010092-uftc8inx 747 43 , , , cord-010092-uftc8inx 747 44 including include VBG cord-010092-uftc8inx 747 45 replacement replacement NN cord-010092-uftc8inx 747 46 donor donor NN cord-010092-uftc8inx 747 47 programs program NNS cord-010092-uftc8inx 747 48 , , , cord-010092-uftc8inx 747 49 with with IN cord-010092-uftc8inx 747 50 retention retention NN cord-010092-uftc8inx 747 51 of of IN cord-010092-uftc8inx 747 52 safe safe JJ cord-010092-uftc8inx 747 53 donors donor NNS cord-010092-uftc8inx 747 54 as as IN cord-010092-uftc8inx 747 55 highest high JJS cord-010092-uftc8inx 747 56 priority priority NN cord-010092-uftc8inx 747 57 . . . cord-010092-uftc8inx 748 1 Fractionation fractionation NN cord-010092-uftc8inx 748 2 of of IN cord-010092-uftc8inx 748 3 blood blood NN cord-010092-uftc8inx 748 4 into into IN cord-010092-uftc8inx 748 5 components component NNS cord-010092-uftc8inx 748 6 had have VBD cord-010092-uftc8inx 748 7 been be VBN cord-010092-uftc8inx 748 8 standard standard JJ cord-010092-uftc8inx 748 9 in in IN cord-010092-uftc8inx 748 10 transfusion transfusion NN cord-010092-uftc8inx 748 11 medicine medicine NN cord-010092-uftc8inx 748 12 , , , cord-010092-uftc8inx 748 13 but but CC cord-010092-uftc8inx 748 14 recently recently RB cord-010092-uftc8inx 748 15 whole whole JJ cord-010092-uftc8inx 748 16 blood blood NN cord-010092-uftc8inx 748 17 has have VBZ cord-010092-uftc8inx 748 18 experienced experience VBN cord-010092-uftc8inx 748 19 revival revival NN cord-010092-uftc8inx 748 20 for for IN cord-010092-uftc8inx 748 21 patients patient NNS cord-010092-uftc8inx 748 22 with with IN cord-010092-uftc8inx 748 23 acute acute JJ cord-010092-uftc8inx 748 24 blood blood NN cord-010092-uftc8inx 748 25 loss loss NN cord-010092-uftc8inx 748 26 . . . cord-010092-uftc8inx 749 1 Given give VBN cord-010092-uftc8inx 749 2 main main JJ cord-010092-uftc8inx 749 3 transfusion transfusion NN cord-010092-uftc8inx 749 4 indications indication NNS cord-010092-uftc8inx 749 5 such such JJ cord-010092-uftc8inx 749 6 as as IN cord-010092-uftc8inx 749 7 postpartum postpartum NN cord-010092-uftc8inx 749 8 hemorrhage hemorrhage NN cord-010092-uftc8inx 749 9 , , , cord-010092-uftc8inx 749 10 or or CC cord-010092-uftc8inx 749 11 severe severe JJ cord-010092-uftc8inx 749 12 trauma trauma NN cord-010092-uftc8inx 749 13 , , , cord-010092-uftc8inx 749 14 in in IN cord-010092-uftc8inx 749 15 regions region NNS cord-010092-uftc8inx 749 16 with with IN cord-010092-uftc8inx 749 17 limited limited JJ cord-010092-uftc8inx 749 18 infrastructure infrastructure NN cord-010092-uftc8inx 749 19 , , , cord-010092-uftc8inx 749 20 whole whole JJ cord-010092-uftc8inx 749 21 blood blood NN cord-010092-uftc8inx 749 22 might may MD cord-010092-uftc8inx 749 23 be be VB cord-010092-uftc8inx 749 24 the the DT cord-010092-uftc8inx 749 25 more more RBR cord-010092-uftc8inx 749 26 appropriate appropriate JJ cord-010092-uftc8inx 749 27 product product NN cord-010092-uftc8inx 749 28 . . . cord-010092-uftc8inx 750 1 Most Most JJS cord-010092-uftc8inx 750 2 patients patient NNS cord-010092-uftc8inx 750 3 requiring require VBG cord-010092-uftc8inx 750 4 transfusion transfusion NN cord-010092-uftc8inx 750 5 in in IN cord-010092-uftc8inx 750 6 these these DT cord-010092-uftc8inx 750 7 regions region NNS cord-010092-uftc8inx 750 8 are be VBP cord-010092-uftc8inx 750 9 younger young JJR cord-010092-uftc8inx 750 10 and and CC cord-010092-uftc8inx 750 11 volume volume NN cord-010092-uftc8inx 750 12 overload overload NN cord-010092-uftc8inx 750 13 by by IN cord-010092-uftc8inx 750 14 whole whole JJ cord-010092-uftc8inx 750 15 blood blood NN cord-010092-uftc8inx 750 16 is be VBZ cord-010092-uftc8inx 750 17 not not RB cord-010092-uftc8inx 750 18 a a DT cord-010092-uftc8inx 750 19 major major JJ cord-010092-uftc8inx 750 20 issue issue NN cord-010092-uftc8inx 750 21 . . . cord-010092-uftc8inx 751 1 In in IN cord-010092-uftc8inx 751 2 addition addition NN cord-010092-uftc8inx 751 3 , , , cord-010092-uftc8inx 751 4 frequent frequent JJ cord-010092-uftc8inx 751 5 electricity electricity NN cord-010092-uftc8inx 751 6 failures failure NNS cord-010092-uftc8inx 751 7 do do VBP cord-010092-uftc8inx 751 8 not not RB cord-010092-uftc8inx 751 9 allow allow VB cord-010092-uftc8inx 751 10 prolonged prolonged JJ cord-010092-uftc8inx 751 11 storage storage NN cord-010092-uftc8inx 751 12 of of IN cord-010092-uftc8inx 751 13 plasma plasma NN cord-010092-uftc8inx 751 14 at at IN cord-010092-uftc8inx 751 15 -20 -20 NNP cord-010092-uftc8inx 751 16 ° ° NNP cord-010092-uftc8inx 751 17 C C NNP cord-010092-uftc8inx 751 18 ( ( -LRB- cord-010092-uftc8inx 751 19 this this DT cord-010092-uftc8inx 751 20 is be VBZ cord-010092-uftc8inx 751 21 therefore therefore RB cord-010092-uftc8inx 751 22 mostly mostly RB cord-010092-uftc8inx 751 23 wasted waste VBN cord-010092-uftc8inx 751 24 ) ) -RRB- cord-010092-uftc8inx 751 25 , , , cord-010092-uftc8inx 751 26 although although IN cord-010092-uftc8inx 751 27 this this DT cord-010092-uftc8inx 751 28 issue issue NN cord-010092-uftc8inx 751 29 can can MD cord-010092-uftc8inx 751 30 be be VB cord-010092-uftc8inx 751 31 overcome overcome VBN cord-010092-uftc8inx 751 32 by by IN cord-010092-uftc8inx 751 33 solar solar JJ cord-010092-uftc8inx 751 34 powered power VBN cord-010092-uftc8inx 751 35 freezers freezer NNS cord-010092-uftc8inx 751 36 . . . cord-010092-uftc8inx 752 1 Ideally ideally RB cord-010092-uftc8inx 752 2 whole whole JJ cord-010092-uftc8inx 752 3 blood blood NN cord-010092-uftc8inx 752 4 should should MD cord-010092-uftc8inx 752 5 be be VB cord-010092-uftc8inx 752 6 pathogen pathogen NN cord-010092-uftc8inx 752 7 inactivated inactivate VBN cord-010092-uftc8inx 752 8 for for IN cord-010092-uftc8inx 752 9 which which WDT cord-010092-uftc8inx 752 10 two two CD cord-010092-uftc8inx 752 11 methods method NNS cord-010092-uftc8inx 752 12 are be VBP cord-010092-uftc8inx 752 13 currently currently RB cord-010092-uftc8inx 752 14 available available JJ cord-010092-uftc8inx 752 15 . . . cord-010092-uftc8inx 753 1 To to TO cord-010092-uftc8inx 753 2 reduce reduce VB cord-010092-uftc8inx 753 3 frequencies frequency NNS cord-010092-uftc8inx 753 4 of of IN cord-010092-uftc8inx 753 5 acute acute JJ cord-010092-uftc8inx 753 6 hemolytic hemolytic JJ cord-010092-uftc8inx 753 7 transfusion transfusion NN cord-010092-uftc8inx 753 8 reactions reaction NNS cord-010092-uftc8inx 753 9 again again RB cord-010092-uftc8inx 753 10 education education NN cord-010092-uftc8inx 753 11 and and CC cord-010092-uftc8inx 753 12 training training NN cord-010092-uftc8inx 753 13 to to TO cord-010092-uftc8inx 753 14 minimize minimize VB cord-010092-uftc8inx 753 15 clerical clerical JJ cord-010092-uftc8inx 753 16 errors error NNS cord-010092-uftc8inx 753 17 in in IN cord-010092-uftc8inx 753 18 the the DT cord-010092-uftc8inx 753 19 transfusion transfusion NN cord-010092-uftc8inx 753 20 process process NN cord-010092-uftc8inx 753 21 are be VBP cord-010092-uftc8inx 753 22 most most RBS cord-010092-uftc8inx 753 23 important important JJ cord-010092-uftc8inx 753 24 . . . cord-010092-uftc8inx 754 1 Extended extended JJ cord-010092-uftc8inx 754 2 testing testing NN cord-010092-uftc8inx 754 3 for for IN cord-010092-uftc8inx 754 4 other other JJ cord-010092-uftc8inx 754 5 Rhesus Rhesus NNP cord-010092-uftc8inx 754 6 antigens antigen NNS cord-010092-uftc8inx 754 7 and and CC cord-010092-uftc8inx 754 8 K K NNP cord-010092-uftc8inx 754 9 beside beside IN cord-010092-uftc8inx 754 10 ABO ABO NNP cord-010092-uftc8inx 754 11 and and CC cord-010092-uftc8inx 754 12 Rh Rh NNP cord-010092-uftc8inx 754 13 - - HYPH cord-010092-uftc8inx 754 14 D D NNP cord-010092-uftc8inx 754 15 in in IN cord-010092-uftc8inx 754 16 transfusion transfusion NN cord-010092-uftc8inx 754 17 dependent dependent JJ cord-010092-uftc8inx 754 18 hemoglobinopathy hemoglobinopathy NNP cord-010092-uftc8inx 754 19 patients patient NNS cord-010092-uftc8inx 754 20 may may MD cord-010092-uftc8inx 754 21 help help VB cord-010092-uftc8inx 754 22 to to TO cord-010092-uftc8inx 754 23 reduce reduce VB cord-010092-uftc8inx 754 24 delayed delay VBN cord-010092-uftc8inx 754 25 hemolytic hemolytic JJ cord-010092-uftc8inx 754 26 transfusion transfusion NN cord-010092-uftc8inx 754 27 reactions reaction NNS cord-010092-uftc8inx 754 28 . . . cord-010092-uftc8inx 755 1 Currently currently RB cord-010092-uftc8inx 755 2 a a DT cord-010092-uftc8inx 755 3 leukodepleted leukodeplete VBN cord-010092-uftc8inx 755 4 pathogen pathogen NN cord-010092-uftc8inx 755 5 - - HYPH cord-010092-uftc8inx 755 6 inactivated inactivate VBN cord-010092-uftc8inx 755 7 whole whole JJ cord-010092-uftc8inx 755 8 blood blood NN cord-010092-uftc8inx 755 9 product product NN cord-010092-uftc8inx 755 10 might may MD cord-010092-uftc8inx 755 11 mostly mostly RB cord-010092-uftc8inx 755 12 serve serve VB cord-010092-uftc8inx 755 13 the the DT cord-010092-uftc8inx 755 14 needs need NNS cord-010092-uftc8inx 755 15 for for IN cord-010092-uftc8inx 755 16 blood blood NN cord-010092-uftc8inx 755 17 transfusion transfusion NN cord-010092-uftc8inx 755 18 in in IN cord-010092-uftc8inx 755 19 regions region NNS cord-010092-uftc8inx 755 20 with with IN cord-010092-uftc8inx 755 21 limited limited JJ cord-010092-uftc8inx 755 22 infrastructure infrastructure NN cord-010092-uftc8inx 755 23 . . . cord-010092-uftc8inx 756 1 The the DT cord-010092-uftc8inx 756 2 developed developed JJ cord-010092-uftc8inx 756 3 world world NN cord-010092-uftc8inx 756 4 should should MD cord-010092-uftc8inx 756 5 invest invest VB cord-010092-uftc8inx 756 6 research research NN cord-010092-uftc8inx 756 7 efforts effort NNS cord-010092-uftc8inx 756 8 to to TO cord-010092-uftc8inx 756 9 develop develop VB cord-010092-uftc8inx 756 10 such such PDT cord-010092-uftc8inx 756 11 a a DT cord-010092-uftc8inx 756 12 product product NN cord-010092-uftc8inx 756 13 available available JJ cord-010092-uftc8inx 756 14 at at IN cord-010092-uftc8inx 756 15 affordable affordable JJ cord-010092-uftc8inx 756 16 costs cost NNS cord-010092-uftc8inx 756 17 . . . cord-010092-uftc8inx 757 1 Background background NN cord-010092-uftc8inx 757 2 : : : cord-010092-uftc8inx 758 1 In in IN cord-010092-uftc8inx 758 2 modern modern JJ cord-010092-uftc8inx 758 3 transfusion transfusion NN cord-010092-uftc8inx 758 4 medicine medicine NN cord-010092-uftc8inx 758 5 , , , cord-010092-uftc8inx 758 6 serological serological JJ cord-010092-uftc8inx 758 7 investigations investigation NNS cord-010092-uftc8inx 758 8 for for IN cord-010092-uftc8inx 758 9 blood blood NN cord-010092-uftc8inx 758 10 cell cell NN cord-010092-uftc8inx 758 11 antigens antigen NNS cord-010092-uftc8inx 758 12 are be VBP cord-010092-uftc8inx 758 13 complemented complement VBN cord-010092-uftc8inx 758 14 by by IN cord-010092-uftc8inx 758 15 genotyping genotype VBG cord-010092-uftc8inx 758 16 arrays array NNS cord-010092-uftc8inx 758 17 and and CC cord-010092-uftc8inx 758 18 PCR PCR NNP cord-010092-uftc8inx 758 19 assays assay NNS cord-010092-uftc8inx 758 20 . . . cord-010092-uftc8inx 759 1 Whilst whilst IN cord-010092-uftc8inx 759 2 these these DT cord-010092-uftc8inx 759 3 platforms platform NNS cord-010092-uftc8inx 759 4 are be VBP cord-010092-uftc8inx 759 5 informative informative JJ cord-010092-uftc8inx 759 6 in in IN cord-010092-uftc8inx 759 7 the the DT cord-010092-uftc8inx 759 8 majority majority NN cord-010092-uftc8inx 759 9 of of IN cord-010092-uftc8inx 759 10 reference reference NN cord-010092-uftc8inx 759 11 investigations investigation NNS cord-010092-uftc8inx 759 12 , , , cord-010092-uftc8inx 759 13 they -PRON- PRP cord-010092-uftc8inx 759 14 are be VBP cord-010092-uftc8inx 759 15 limited limit VBN cord-010092-uftc8inx 759 16 in in IN cord-010092-uftc8inx 759 17 their -PRON- PRP$ cord-010092-uftc8inx 759 18 ability ability NN cord-010092-uftc8inx 759 19 to to TO cord-010092-uftc8inx 759 20 define define VB cord-010092-uftc8inx 759 21 nucleotide nucleotide JJ cord-010092-uftc8inx 759 22 variants variant NNS cord-010092-uftc8inx 759 23 associated associate VBN cord-010092-uftc8inx 759 24 with with IN cord-010092-uftc8inx 759 25 rare rare JJ cord-010092-uftc8inx 759 26 antigens antigen NNS cord-010092-uftc8inx 759 27 and and CC cord-010092-uftc8inx 759 28 unable unable JJ cord-010092-uftc8inx 759 29 to to TO cord-010092-uftc8inx 759 30 detect detect VB cord-010092-uftc8inx 759 31 novel novel JJ cord-010092-uftc8inx 759 32 variants variant NNS cord-010092-uftc8inx 759 33 potentially potentially RB cord-010092-uftc8inx 759 34 affecting affect VBG cord-010092-uftc8inx 759 35 antigenicity antigenicity NN cord-010092-uftc8inx 759 36 . . . cord-010092-uftc8inx 760 1 Next next JJ cord-010092-uftc8inx 760 2 - - HYPH cord-010092-uftc8inx 760 3 generation generation NN cord-010092-uftc8inx 760 4 sequencing sequencing NN cord-010092-uftc8inx 760 5 is be VBZ cord-010092-uftc8inx 760 6 increasingly increasingly RB cord-010092-uftc8inx 760 7 being be VBG cord-010092-uftc8inx 760 8 employed employ VBN cord-010092-uftc8inx 760 9 in in IN cord-010092-uftc8inx 760 10 reference reference NN cord-010092-uftc8inx 760 11 settings setting NNS cord-010092-uftc8inx 760 12 , , , cord-010092-uftc8inx 760 13 providing provide VBG cord-010092-uftc8inx 760 14 information information NN cord-010092-uftc8inx 760 15 that that WDT cord-010092-uftc8inx 760 16 can can MD cord-010092-uftc8inx 760 17 not not RB cord-010092-uftc8inx 760 18 be be VB cord-010092-uftc8inx 760 19 obtained obtain VBN cord-010092-uftc8inx 760 20 through through IN cord-010092-uftc8inx 760 21 these these DT cord-010092-uftc8inx 760 22 methods method NNS cord-010092-uftc8inx 760 23 . . . cord-010092-uftc8inx 761 1 Whole whole JJ cord-010092-uftc8inx 761 2 genome genome NN cord-010092-uftc8inx 761 3 and and CC cord-010092-uftc8inx 761 4 whole whole JJ cord-010092-uftc8inx 761 5 exome exome NN cord-010092-uftc8inx 761 6 sequencing sequencing NN cord-010092-uftc8inx 761 7 have have VBP cord-010092-uftc8inx 761 8 been be VBN cord-010092-uftc8inx 761 9 successfully successfully RB cord-010092-uftc8inx 761 10 employed employ VBN cord-010092-uftc8inx 761 11 in in IN cord-010092-uftc8inx 761 12 many many JJ cord-010092-uftc8inx 761 13 investigations investigation NNS cord-010092-uftc8inx 761 14 of of IN cord-010092-uftc8inx 761 15 novel novel JJ cord-010092-uftc8inx 761 16 and and CC cord-010092-uftc8inx 761 17 rare rare JJ cord-010092-uftc8inx 761 18 antigens antigen NNS cord-010092-uftc8inx 761 19 , , , cord-010092-uftc8inx 761 20 however however WRB cord-010092-uftc8inx 761 21 concerns concern NNS cord-010092-uftc8inx 761 22 remain remain VBP cord-010092-uftc8inx 761 23 regarding regard VBG cord-010092-uftc8inx 761 24 the the DT cord-010092-uftc8inx 761 25 collection collection NN cord-010092-uftc8inx 761 26 of of IN cord-010092-uftc8inx 761 27 genomic genomic JJ cord-010092-uftc8inx 761 28 data datum NNS cord-010092-uftc8inx 761 29 unrelated unrelated JJ cord-010092-uftc8inx 761 30 to to TO cord-010092-uftc8inx 761 31 reference reference NN cord-010092-uftc8inx 761 32 investigations investigation NNS cord-010092-uftc8inx 761 33 , , , cord-010092-uftc8inx 761 34 and and CC cord-010092-uftc8inx 761 35 reporting report VBG cord-010092-uftc8inx 761 36 clinically clinically RB cord-010092-uftc8inx 761 37 significant significant JJ cord-010092-uftc8inx 761 38 incidental incidental JJ cord-010092-uftc8inx 761 39 findings finding NNS cord-010092-uftc8inx 761 40 . . . cord-010092-uftc8inx 762 1 These these DT cord-010092-uftc8inx 762 2 concerns concern NNS cord-010092-uftc8inx 762 3 can can MD cord-010092-uftc8inx 762 4 be be VB cord-010092-uftc8inx 762 5 addressed address VBN cord-010092-uftc8inx 762 6 through through IN cord-010092-uftc8inx 762 7 the the DT cord-010092-uftc8inx 762 8 use use NN cord-010092-uftc8inx 762 9 of of IN cord-010092-uftc8inx 762 10 targeted target VBN cord-010092-uftc8inx 762 11 sequencing sequencing NN cord-010092-uftc8inx 762 12 panels panel NNS cord-010092-uftc8inx 762 13 . . . cord-010092-uftc8inx 763 1 We -PRON- PRP cord-010092-uftc8inx 763 2 report report VBP cord-010092-uftc8inx 763 3 on on IN cord-010092-uftc8inx 763 4 the the DT cord-010092-uftc8inx 763 5 design design NN cord-010092-uftc8inx 763 6 , , , cord-010092-uftc8inx 763 7 testing testing NN cord-010092-uftc8inx 763 8 and and CC cord-010092-uftc8inx 763 9 efficacy efficacy NN cord-010092-uftc8inx 763 10 of of IN cord-010092-uftc8inx 763 11 a a DT cord-010092-uftc8inx 763 12 panel panel NN cord-010092-uftc8inx 763 13 providing provide VBG cord-010092-uftc8inx 763 14 a a DT cord-010092-uftc8inx 763 15 comprehensive comprehensive JJ cord-010092-uftc8inx 763 16 genotyping genotyping NN cord-010092-uftc8inx 763 17 profile profile NN cord-010092-uftc8inx 763 18 for for IN cord-010092-uftc8inx 763 19 red red JJ cord-010092-uftc8inx 763 20 cell cell NN cord-010092-uftc8inx 763 21 , , , cord-010092-uftc8inx 763 22 platelet platelet NN cord-010092-uftc8inx 763 23 and and CC cord-010092-uftc8inx 763 24 neutrophil neutrophil NN cord-010092-uftc8inx 763 25 antigens antigen NNS cord-010092-uftc8inx 763 26 in in IN cord-010092-uftc8inx 763 27 a a DT cord-010092-uftc8inx 763 28 single single JJ cord-010092-uftc8inx 763 29 test test NN cord-010092-uftc8inx 763 30 . . . cord-010092-uftc8inx 764 1 Aims aim VBZ cord-010092-uftc8inx 764 2 : : : cord-010092-uftc8inx 764 3 Design design VB cord-010092-uftc8inx 764 4 a a DT cord-010092-uftc8inx 764 5 customised customised JJ cord-010092-uftc8inx 764 6 targeted target VBN cord-010092-uftc8inx 764 7 exome exome NN cord-010092-uftc8inx 764 8 sequencing sequencing NN cord-010092-uftc8inx 764 9 panel panel NN cord-010092-uftc8inx 764 10 for for IN cord-010092-uftc8inx 764 11 red red JJ cord-010092-uftc8inx 764 12 cell cell NN cord-010092-uftc8inx 764 13 , , , cord-010092-uftc8inx 764 14 platelet platelet NN cord-010092-uftc8inx 764 15 and and CC cord-010092-uftc8inx 764 16 neutrophil neutrophil NN cord-010092-uftc8inx 764 17 antigen antigen NN cord-010092-uftc8inx 764 18 genes gene NNS cord-010092-uftc8inx 764 19 , , , cord-010092-uftc8inx 764 20 and and CC cord-010092-uftc8inx 764 21 benchmark benchmark VBD cord-010092-uftc8inx 764 22 the the DT cord-010092-uftc8inx 764 23 efficacy efficacy NN cord-010092-uftc8inx 764 24 against against IN cord-010092-uftc8inx 764 25 a a DT cord-010092-uftc8inx 764 26 commercial commercial JJ cord-010092-uftc8inx 764 27 medical medical JJ cord-010092-uftc8inx 764 28 sequencing sequencing NN cord-010092-uftc8inx 764 29 panel panel NN cord-010092-uftc8inx 764 30 ( ( -LRB- cord-010092-uftc8inx 764 31 Illumina Illumina NNP cord-010092-uftc8inx 764 32 TruSight TruSight NNP cord-010092-uftc8inx 764 33 One one CD cord-010092-uftc8inx 764 34 -TSO -TSO -RRB- cord-010092-uftc8inx 764 35 ) ) -RRB- cord-010092-uftc8inx 764 36 . . . cord-010092-uftc8inx 765 1 -Test -Test NNP cord-010092-uftc8inx 766 1 the the DT cord-010092-uftc8inx 766 2 panel panel NN cord-010092-uftc8inx 766 3 and and CC cord-010092-uftc8inx 766 4 in in IN cord-010092-uftc8inx 766 5 - - HYPH cord-010092-uftc8inx 766 6 house house NN cord-010092-uftc8inx 766 7 genotype genotype NN cord-010092-uftc8inx 766 8 prediction prediction NN cord-010092-uftc8inx 766 9 script script NN cord-010092-uftc8inx 766 10 on on IN cord-010092-uftc8inx 766 11 sequence sequence NN cord-010092-uftc8inx 766 12 outputs output NNS cord-010092-uftc8inx 766 13 from from IN cord-010092-uftc8inx 766 14 51 51 CD cord-010092-uftc8inx 766 15 samples sample NNS cord-010092-uftc8inx 766 16 with with IN cord-010092-uftc8inx 766 17 known know VBN cord-010092-uftc8inx 766 18 red red JJ cord-010092-uftc8inx 766 19 cell cell NN cord-010092-uftc8inx 766 20 , , , cord-010092-uftc8inx 766 21 platelet platelet NN cord-010092-uftc8inx 766 22 and and CC cord-010092-uftc8inx 766 23 neutrophil neutrophil NN cord-010092-uftc8inx 766 24 genotypes genotype NNS cord-010092-uftc8inx 766 25 and and CC cord-010092-uftc8inx 766 26 phenotypes phenotype NNS cord-010092-uftc8inx 766 27 and and CC cord-010092-uftc8inx 766 28 determine determine VBP cord-010092-uftc8inx 766 29 whether whether IN cord-010092-uftc8inx 766 30 predictions prediction NNS cord-010092-uftc8inx 766 31 are be VBP cord-010092-uftc8inx 766 32 concordant concordant JJ cord-010092-uftc8inx 766 33 . . . cord-010092-uftc8inx 767 1 Methods method NNS cord-010092-uftc8inx 767 2 : : : cord-010092-uftc8inx 768 1 The the DT cord-010092-uftc8inx 768 2 panel panel NN cord-010092-uftc8inx 768 3 was be VBD cord-010092-uftc8inx 768 4 designed design VBN cord-010092-uftc8inx 768 5 with with IN cord-010092-uftc8inx 768 6 2654 2654 CD cord-010092-uftc8inx 768 7 probes probe NNS cord-010092-uftc8inx 768 8 covering cover VBG cord-010092-uftc8inx 768 9 exons exon NNS cord-010092-uftc8inx 768 10 of of IN cord-010092-uftc8inx 768 11 64 64 CD cord-010092-uftc8inx 768 12 genes gene NNS cord-010092-uftc8inx 768 13 associated associate VBN cord-010092-uftc8inx 768 14 with with IN cord-010092-uftc8inx 768 15 red red JJ cord-010092-uftc8inx 768 16 cell cell NN cord-010092-uftc8inx 768 17 , , , cord-010092-uftc8inx 768 18 platelet platelet NN cord-010092-uftc8inx 768 19 and and CC cord-010092-uftc8inx 768 20 neutrophil neutrophil NN cord-010092-uftc8inx 768 21 antigens antigen NNS cord-010092-uftc8inx 768 22 . . . cord-010092-uftc8inx 769 1 Using use VBG cord-010092-uftc8inx 769 2 Illumina Illumina NNP cord-010092-uftc8inx 769 3 Nextera Nextera NNP cord-010092-uftc8inx 769 4 rapid rapid JJ cord-010092-uftc8inx 769 5 capture capture NN cord-010092-uftc8inx 769 6 technology technology NN cord-010092-uftc8inx 769 7 , , , cord-010092-uftc8inx 769 8 51 51 CD cord-010092-uftc8inx 769 9 samples sample NNS cord-010092-uftc8inx 769 10 were be VBD cord-010092-uftc8inx 769 11 tested test VBN cord-010092-uftc8inx 769 12 over over IN cord-010092-uftc8inx 769 13 five five CD cord-010092-uftc8inx 769 14 sequencing sequencing NN cord-010092-uftc8inx 769 15 runs run NNS cord-010092-uftc8inx 769 16 , , , cord-010092-uftc8inx 769 17 on on IN cord-010092-uftc8inx 769 18 standard standard JJ cord-010092-uftc8inx 769 19 and and CC cord-010092-uftc8inx 769 20 micro micro JJ cord-010092-uftc8inx 769 21 chemistries chemistry NNS cord-010092-uftc8inx 769 22 , , , cord-010092-uftc8inx 769 23 to to TO cord-010092-uftc8inx 769 24 determine determine VB cord-010092-uftc8inx 769 25 optimal optimal JJ cord-010092-uftc8inx 769 26 sample sample NN cord-010092-uftc8inx 769 27 plexity plexity NN cord-010092-uftc8inx 769 28 per per IN cord-010092-uftc8inx 769 29 standard standard JJ cord-010092-uftc8inx 769 30 run run NN cord-010092-uftc8inx 769 31 , , , cord-010092-uftc8inx 769 32 and and CC cord-010092-uftc8inx 769 33 the the DT cord-010092-uftc8inx 769 34 efficacy efficacy NN cord-010092-uftc8inx 769 35 of of IN cord-010092-uftc8inx 769 36 smaller small JJR cord-010092-uftc8inx 769 37 flow flow NN cord-010092-uftc8inx 769 38 cells cell NNS cord-010092-uftc8inx 769 39 for for IN cord-010092-uftc8inx 769 40 lower low JJR cord-010092-uftc8inx 769 41 throughput throughput NN cord-010092-uftc8inx 769 42 applications application NNS cord-010092-uftc8inx 769 43 . . . cord-010092-uftc8inx 770 1 An an DT cord-010092-uftc8inx 770 2 in in IN cord-010092-uftc8inx 770 3 - - HYPH cord-010092-uftc8inx 770 4 house house NN cord-010092-uftc8inx 770 5 python python NN cord-010092-uftc8inx 770 6 script script NN cord-010092-uftc8inx 770 7 was be VBD cord-010092-uftc8inx 770 8 used use VBN cord-010092-uftc8inx 770 9 to to TO cord-010092-uftc8inx 770 10 predict predict VB cord-010092-uftc8inx 770 11 star star NN cord-010092-uftc8inx 770 12 - - HYPH cord-010092-uftc8inx 770 13 allele allele NN cord-010092-uftc8inx 770 14 genotypes genotype NNS cord-010092-uftc8inx 770 15 based base VBN cord-010092-uftc8inx 770 16 on on IN cord-010092-uftc8inx 770 17 variants variant NNS cord-010092-uftc8inx 770 18 listed list VBN cord-010092-uftc8inx 770 19 in in IN cord-010092-uftc8inx 770 20 ISBT ISBT NNP cord-010092-uftc8inx 770 21 and and CC cord-010092-uftc8inx 770 22 EMBL EMBL NNP cord-010092-uftc8inx 770 23 databases database NNS cord-010092-uftc8inx 770 24 . . . cord-010092-uftc8inx 771 1 These these DT cord-010092-uftc8inx 771 2 predictions prediction NNS cord-010092-uftc8inx 771 3 were be VBD cord-010092-uftc8inx 771 4 compared compare VBN cord-010092-uftc8inx 771 5 to to IN cord-010092-uftc8inx 771 6 results result NNS cord-010092-uftc8inx 771 7 from from IN cord-010092-uftc8inx 771 8 serology serology NN cord-010092-uftc8inx 771 9 , , , cord-010092-uftc8inx 771 10 SNP SNP NNP cord-010092-uftc8inx 771 11 array array NN cord-010092-uftc8inx 771 12 and and CC cord-010092-uftc8inx 771 13 previous previous JJ cord-010092-uftc8inx 771 14 TSO TSO NNP cord-010092-uftc8inx 771 15 data datum NNS cord-010092-uftc8inx 771 16 . . . cord-010092-uftc8inx 772 1 Results result NNS cord-010092-uftc8inx 772 2 : : : cord-010092-uftc8inx 773 1 Coverage coverage NN cord-010092-uftc8inx 773 2 consistently consistently RB cord-010092-uftc8inx 773 3 averaged average VBD cord-010092-uftc8inx 773 4 > > XX cord-010092-uftc8inx 773 5 2509 2509 CD cord-010092-uftc8inx 773 6 , , , cord-010092-uftc8inx 773 7 with with IN cord-010092-uftc8inx 773 8 94 94 CD cord-010092-uftc8inx 773 9 % % NN cord-010092-uftc8inx 773 10 of of IN cord-010092-uftc8inx 773 11 target target NN cord-010092-uftc8inx 773 12 at at IN cord-010092-uftc8inx 773 13 a a DT cord-010092-uftc8inx 773 14 quality quality NN cord-010092-uftc8inx 773 15 of of IN cord-010092-uftc8inx 773 16 Q30 Q30 NNP cord-010092-uftc8inx 773 17 . . . cord-010092-uftc8inx 774 1 Optimal optimal JJ cord-010092-uftc8inx 774 2 sample sample NN cord-010092-uftc8inx 774 3 plexity plexity NN cord-010092-uftc8inx 774 4 for for IN cord-010092-uftc8inx 774 5 a a DT cord-010092-uftc8inx 774 6 standard standard JJ cord-010092-uftc8inx 774 7 run run NN cord-010092-uftc8inx 774 8 was be VBD cord-010092-uftc8inx 774 9 determined determine VBN cord-010092-uftc8inx 774 10 to to TO cord-010092-uftc8inx 774 11 be be VB cord-010092-uftc8inx 774 12 14 14 CD cord-010092-uftc8inx 774 13 samples sample NNS cord-010092-uftc8inx 774 14 , , , cord-010092-uftc8inx 774 15 allowing allow VBG cord-010092-uftc8inx 774 16 for for IN cord-010092-uftc8inx 774 17 sufficient sufficient JJ cord-010092-uftc8inx 774 18 coverage coverage NN cord-010092-uftc8inx 774 19 of of IN cord-010092-uftc8inx 774 20 all all DT cord-010092-uftc8inx 774 21 clinically clinically RB cord-010092-uftc8inx 774 22 significant significant JJ cord-010092-uftc8inx 774 23 variants variant NNS cord-010092-uftc8inx 774 24 . . . cord-010092-uftc8inx 775 1 For for IN cord-010092-uftc8inx 775 2 red red JJ cord-010092-uftc8inx 775 3 cell cell NN cord-010092-uftc8inx 775 4 samples sample NNS cord-010092-uftc8inx 775 5 with with IN cord-010092-uftc8inx 775 6 previous previous JJ cord-010092-uftc8inx 775 7 typing typing NN cord-010092-uftc8inx 775 8 data datum NNS cord-010092-uftc8inx 775 9 ( ( -LRB- cord-010092-uftc8inx 775 10 excluding exclude VBG cord-010092-uftc8inx 775 11 RH RH NNP cord-010092-uftc8inx 775 12 structural structural JJ cord-010092-uftc8inx 775 13 variants variant NNS cord-010092-uftc8inx 775 14 ) ) -RRB- cord-010092-uftc8inx 775 15 , , , cord-010092-uftc8inx 775 16 the the DT cord-010092-uftc8inx 775 17 script script NN cord-010092-uftc8inx 775 18 correctly correctly RB cord-010092-uftc8inx 775 19 predicted predict VBD cord-010092-uftc8inx 775 20 99.5 99.5 CD cord-010092-uftc8inx 775 21 % % NN cord-010092-uftc8inx 775 22 of of IN cord-010092-uftc8inx 775 23 SNP SNP NNP cord-010092-uftc8inx 775 24 based base VBN cord-010092-uftc8inx 775 25 red red JJ cord-010092-uftc8inx 775 26 cell cell NN cord-010092-uftc8inx 775 27 genotypes genotype NNS cord-010092-uftc8inx 775 28 . . . cord-010092-uftc8inx 776 1 Script script NN cord-010092-uftc8inx 776 2 predictions prediction NNS cord-010092-uftc8inx 776 3 were be VBD cord-010092-uftc8inx 776 4 100 100 CD cord-010092-uftc8inx 776 5 % % NN cord-010092-uftc8inx 776 6 concordant concordant JJ cord-010092-uftc8inx 776 7 for for IN cord-010092-uftc8inx 776 8 platelet platelet NN cord-010092-uftc8inx 776 9 genotypes genotype NNS cord-010092-uftc8inx 776 10 , , , cord-010092-uftc8inx 776 11 and and CC cord-010092-uftc8inx 776 12 four four CD cord-010092-uftc8inx 776 13 of of IN cord-010092-uftc8inx 776 14 five five CD cord-010092-uftc8inx 776 15 neutrophil neutrophil NN cord-010092-uftc8inx 776 16 antigen antigen NN cord-010092-uftc8inx 776 17 genotypes genotype NNS cord-010092-uftc8inx 776 18 . . . cord-010092-uftc8inx 777 1 HNA2 HNA2 NNP cord-010092-uftc8inx 777 2 genotypes genotype NNS cord-010092-uftc8inx 777 3 defined define VBN cord-010092-uftc8inx 777 4 by by IN cord-010092-uftc8inx 777 5 CD177 CD177 NNP cord-010092-uftc8inx 777 6 could could MD cord-010092-uftc8inx 777 7 not not RB cord-010092-uftc8inx 777 8 be be VB cord-010092-uftc8inx 777 9 reliably reliably RB cord-010092-uftc8inx 777 10 determined determine VBN cord-010092-uftc8inx 777 11 . . . cord-010092-uftc8inx 778 1 The the DT cord-010092-uftc8inx 778 2 increased increase VBN cord-010092-uftc8inx 778 3 target target NN cord-010092-uftc8inx 778 4 coverage coverage NN cord-010092-uftc8inx 778 5 of of IN cord-010092-uftc8inx 778 6 the the DT cord-010092-uftc8inx 778 7 panel panel NN cord-010092-uftc8inx 778 8 allowed allow VBN cord-010092-uftc8inx 778 9 for for IN cord-010092-uftc8inx 778 10 detection detection NN cord-010092-uftc8inx 778 11 of of IN cord-010092-uftc8inx 778 12 a a DT cord-010092-uftc8inx 778 13 clinically clinically RB cord-010092-uftc8inx 778 14 significant significant JJ cord-010092-uftc8inx 778 15 heterozygous heterozygous JJ cord-010092-uftc8inx 778 16 variant variant NN cord-010092-uftc8inx 778 17 in in IN cord-010092-uftc8inx 778 18 Scianna Scianna NNP cord-010092-uftc8inx 778 19 system system NN cord-010092-uftc8inx 778 20 , , , cord-010092-uftc8inx 778 21 previously previously RB cord-010092-uftc8inx 778 22 undetected undetected JJ cord-010092-uftc8inx 778 23 by by IN cord-010092-uftc8inx 778 24 the the DT cord-010092-uftc8inx 778 25 TSO TSO NNP cord-010092-uftc8inx 778 26 panel panel NN cord-010092-uftc8inx 778 27 due due IN cord-010092-uftc8inx 778 28 to to IN cord-010092-uftc8inx 778 29 extremely extremely RB cord-010092-uftc8inx 778 30 low low JJ cord-010092-uftc8inx 778 31 coverage coverage NN cord-010092-uftc8inx 778 32 . . . cord-010092-uftc8inx 779 1 Additionally additionally RB cord-010092-uftc8inx 779 2 , , , cord-010092-uftc8inx 779 3 a a DT cord-010092-uftc8inx 779 4 variant variant NN cord-010092-uftc8inx 779 5 defining define VBG cord-010092-uftc8inx 779 6 a a DT cord-010092-uftc8inx 779 7 potentially potentially RB cord-010092-uftc8inx 779 8 novel novel JJ cord-010092-uftc8inx 779 9 null null NN cord-010092-uftc8inx 779 10 allele allele NN cord-010092-uftc8inx 779 11 was be VBD cord-010092-uftc8inx 779 12 detected detect VBN cord-010092-uftc8inx 779 13 in in IN cord-010092-uftc8inx 779 14 the the DT cord-010092-uftc8inx 779 15 P1PK P1PK NNP cord-010092-uftc8inx 779 16 system system NN cord-010092-uftc8inx 779 17 . . . cord-010092-uftc8inx 780 1 Summary Summary NNP cord-010092-uftc8inx 780 2 / / SYM cord-010092-uftc8inx 780 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 780 4 : : : cord-010092-uftc8inx 781 1 The the DT cord-010092-uftc8inx 781 2 panel panel NN cord-010092-uftc8inx 781 3 demonstrates demonstrate VBZ cord-010092-uftc8inx 781 4 considerably considerably RB cord-010092-uftc8inx 781 5 higher high JJR cord-010092-uftc8inx 781 6 coverage coverage NN cord-010092-uftc8inx 781 7 , , , cord-010092-uftc8inx 781 8 quality quality NN cord-010092-uftc8inx 781 9 and and CC cord-010092-uftc8inx 781 10 throughput throughput NN cord-010092-uftc8inx 781 11 compared compare VBN cord-010092-uftc8inx 781 12 to to IN cord-010092-uftc8inx 781 13 the the DT cord-010092-uftc8inx 781 14 TSO TSO NNP cord-010092-uftc8inx 781 15 and and CC cord-010092-uftc8inx 781 16 allows allow VBZ cord-010092-uftc8inx 781 17 for for IN cord-010092-uftc8inx 781 18 detection detection NN cord-010092-uftc8inx 781 19 of of IN cord-010092-uftc8inx 781 20 variants variant NNS cord-010092-uftc8inx 781 21 previously previously RB cord-010092-uftc8inx 781 22 overlooked overlook VBN cord-010092-uftc8inx 781 23 due due IN cord-010092-uftc8inx 781 24 to to IN cord-010092-uftc8inx 781 25 low low JJ cord-010092-uftc8inx 781 26 sequencing sequencing NN cord-010092-uftc8inx 781 27 coverage coverage NN cord-010092-uftc8inx 781 28 . . . cord-010092-uftc8inx 782 1 Up up IN cord-010092-uftc8inx 782 2 to to TO cord-010092-uftc8inx 782 3 14 14 CD cord-010092-uftc8inx 782 4 samples sample NNS cord-010092-uftc8inx 782 5 can can MD cord-010092-uftc8inx 782 6 be be VB cord-010092-uftc8inx 782 7 reliably reliably RB cord-010092-uftc8inx 782 8 sequenced sequence VBN cord-010092-uftc8inx 782 9 in in IN cord-010092-uftc8inx 782 10 a a DT cord-010092-uftc8inx 782 11 single single JJ cord-010092-uftc8inx 782 12 run run NN cord-010092-uftc8inx 782 13 . . . cord-010092-uftc8inx 783 1 Our -PRON- PRP$ cord-010092-uftc8inx 783 2 script script NN cord-010092-uftc8inx 783 3 correctly correctly RB cord-010092-uftc8inx 783 4 predicts predict VBZ cord-010092-uftc8inx 783 5 over over IN cord-010092-uftc8inx 783 6 99 99 CD cord-010092-uftc8inx 783 7 % % NN cord-010092-uftc8inx 783 8 of of IN cord-010092-uftc8inx 783 9 SNP SNP NNP cord-010092-uftc8inx 783 10 based base VBN cord-010092-uftc8inx 783 11 alleles allele NNS cord-010092-uftc8inx 783 12 ; ; : cord-010092-uftc8inx 783 13 however however RB cord-010092-uftc8inx 783 14 , , , cord-010092-uftc8inx 783 15 RH RH NNP cord-010092-uftc8inx 783 16 structural structural JJ cord-010092-uftc8inx 783 17 variants variant NNS cord-010092-uftc8inx 783 18 require require VBP cord-010092-uftc8inx 783 19 further further JJ cord-010092-uftc8inx 783 20 manual manual JJ cord-010092-uftc8inx 783 21 analysis analysis NN cord-010092-uftc8inx 783 22 . . . cord-010092-uftc8inx 784 1 Background background NN cord-010092-uftc8inx 784 2 : : : cord-010092-uftc8inx 785 1 To to TO cord-010092-uftc8inx 785 2 ensure ensure VB cord-010092-uftc8inx 785 3 the the DT cord-010092-uftc8inx 785 4 safety safety NN cord-010092-uftc8inx 785 5 of of IN cord-010092-uftc8inx 785 6 a a DT cord-010092-uftc8inx 785 7 transfusion transfusion NN cord-010092-uftc8inx 785 8 it -PRON- PRP cord-010092-uftc8inx 785 9 is be VBZ cord-010092-uftc8inx 785 10 critical critical JJ cord-010092-uftc8inx 785 11 to to TO cord-010092-uftc8inx 785 12 identify identify VB cord-010092-uftc8inx 785 13 the the DT cord-010092-uftc8inx 785 14 blood blood NN cord-010092-uftc8inx 785 15 type type NN cord-010092-uftc8inx 785 16 of of IN cord-010092-uftc8inx 785 17 both both DT cord-010092-uftc8inx 785 18 donor donor NN cord-010092-uftc8inx 785 19 and and CC cord-010092-uftc8inx 785 20 recipient recipient NN cord-010092-uftc8inx 785 21 . . . cord-010092-uftc8inx 786 1 Serological serological JJ cord-010092-uftc8inx 786 2 methods method NNS cord-010092-uftc8inx 786 3 for for IN cord-010092-uftc8inx 786 4 typing type VBG cord-010092-uftc8inx 786 5 ABO ABO NNP cord-010092-uftc8inx 786 6 , , , cord-010092-uftc8inx 786 7 RH RH NNP cord-010092-uftc8inx 786 8 and and CC cord-010092-uftc8inx 786 9 KEL KEL NNP cord-010092-uftc8inx 786 10 use use VBP cord-010092-uftc8inx 786 11 monoclonal monoclonal JJ cord-010092-uftc8inx 786 12 antibodies antibody NNS cord-010092-uftc8inx 786 13 , , , cord-010092-uftc8inx 786 14 however however RB cord-010092-uftc8inx 786 15 , , , cord-010092-uftc8inx 786 16 typing type VBG cord-010092-uftc8inx 786 17 reagents reagent NNS cord-010092-uftc8inx 786 18 for for IN cord-010092-uftc8inx 786 19 rare rare JJ cord-010092-uftc8inx 786 20 blood blood NN cord-010092-uftc8inx 786 21 groups group NNS cord-010092-uftc8inx 786 22 are be VBP cord-010092-uftc8inx 786 23 expensive expensive JJ cord-010092-uftc8inx 786 24 , , , cord-010092-uftc8inx 786 25 unavailable unavailable JJ cord-010092-uftc8inx 786 26 or or CC cord-010092-uftc8inx 786 27 unreliable unreliable JJ cord-010092-uftc8inx 786 28 . . . cord-010092-uftc8inx 787 1 DNA dna NN cord-010092-uftc8inx 787 2 - - HYPH cord-010092-uftc8inx 787 3 based base VBN cord-010092-uftc8inx 787 4 identification identification NN cord-010092-uftc8inx 787 5 of of IN cord-010092-uftc8inx 787 6 human human JJ cord-010092-uftc8inx 787 7 blood blood NN cord-010092-uftc8inx 787 8 groups group NNS cord-010092-uftc8inx 787 9 has have VBZ cord-010092-uftc8inx 787 10 been be VBN cord-010092-uftc8inx 787 11 used use VBN cord-010092-uftc8inx 787 12 to to TO cord-010092-uftc8inx 787 13 overcome overcome VB cord-010092-uftc8inx 787 14 these these DT cord-010092-uftc8inx 787 15 limitations limitation NNS cord-010092-uftc8inx 787 16 and and CC cord-010092-uftc8inx 787 17 its -PRON- PRP$ cord-010092-uftc8inx 787 18 application application NN cord-010092-uftc8inx 787 19 has have VBZ cord-010092-uftc8inx 787 20 reduced reduce VBN cord-010092-uftc8inx 787 21 rates rate NNS cord-010092-uftc8inx 787 22 of of IN cord-010092-uftc8inx 787 23 alloimmunisation alloimmunisation NN cord-010092-uftc8inx 787 24 in in IN cord-010092-uftc8inx 787 25 chronically chronically RB cord-010092-uftc8inx 787 26 transfused transfuse VBN cord-010092-uftc8inx 787 27 patients patient NNS cord-010092-uftc8inx 787 28 . . . cord-010092-uftc8inx 788 1 However however RB cord-010092-uftc8inx 788 2 , , , cord-010092-uftc8inx 788 3 to to IN cord-010092-uftc8inx 788 4 date date NN cord-010092-uftc8inx 788 5 , , , cord-010092-uftc8inx 788 6 the the DT cord-010092-uftc8inx 788 7 cost cost NN cord-010092-uftc8inx 788 8 per per IN cord-010092-uftc8inx 788 9 sample sample NN cord-010092-uftc8inx 788 10 has have VBZ cord-010092-uftc8inx 788 11 prevented prevent VBN cord-010092-uftc8inx 788 12 the the DT cord-010092-uftc8inx 788 13 universal universal JJ cord-010092-uftc8inx 788 14 application application NN cord-010092-uftc8inx 788 15 of of IN cord-010092-uftc8inx 788 16 DNA dna NN cord-010092-uftc8inx 788 17 - - HYPH cord-010092-uftc8inx 788 18 based base VBN cord-010092-uftc8inx 788 19 donor donor NN cord-010092-uftc8inx 788 20 typing typing NN cord-010092-uftc8inx 788 21 Aims aim VBZ cord-010092-uftc8inx 788 22 : : : cord-010092-uftc8inx 788 23 To to TO cord-010092-uftc8inx 788 24 achieve achieve VB cord-010092-uftc8inx 788 25 universal universal JJ cord-010092-uftc8inx 788 26 adoption adoption NN cord-010092-uftc8inx 788 27 of of IN cord-010092-uftc8inx 788 28 DNA DNA NNP cord-010092-uftc8inx 788 29 based base VBN cord-010092-uftc8inx 788 30 donor donor NN cord-010092-uftc8inx 788 31 typing typing NN cord-010092-uftc8inx 788 32 , , , cord-010092-uftc8inx 788 33 the the DT cord-010092-uftc8inx 788 34 Blood Blood NNP cord-010092-uftc8inx 788 35 transfusion transfusion NN cord-010092-uftc8inx 788 36 Genomics Genomics NNP cord-010092-uftc8inx 788 37 Consortium Consortium NNP cord-010092-uftc8inx 788 38 ( ( -LRB- cord-010092-uftc8inx 788 39 BGC BGC NNP cord-010092-uftc8inx 788 40 ) ) -RRB- cord-010092-uftc8inx 788 41 set set VBD cord-010092-uftc8inx 788 42 out out RP cord-010092-uftc8inx 788 43 to to TO cord-010092-uftc8inx 788 44 develop develop VB cord-010092-uftc8inx 788 45 an an DT cord-010092-uftc8inx 788 46 affordable affordable JJ cord-010092-uftc8inx 788 47 DNA dna NN cord-010092-uftc8inx 788 48 based base VBN cord-010092-uftc8inx 788 49 platform platform NN cord-010092-uftc8inx 788 50 , , , cord-010092-uftc8inx 788 51 capable capable JJ cord-010092-uftc8inx 788 52 of of IN cord-010092-uftc8inx 788 53 typing type VBG cord-010092-uftc8inx 788 54 all all DT cord-010092-uftc8inx 788 55 red red JJ cord-010092-uftc8inx 788 56 cell cell NN cord-010092-uftc8inx 788 57 antigens antigen NNS cord-010092-uftc8inx 788 58 , , , cord-010092-uftc8inx 788 59 HLA HLA NNP cord-010092-uftc8inx 788 60 class class NN cord-010092-uftc8inx 788 61 I i NN cord-010092-uftc8inx 788 62 and and CC cord-010092-uftc8inx 788 63 II II NNP cord-010092-uftc8inx 788 64 and and CC cord-010092-uftc8inx 788 65 Human Human NNP cord-010092-uftc8inx 788 66 Platelet Platelet NNP cord-010092-uftc8inx 788 67 Antigens Antigens NNP cord-010092-uftc8inx 788 68 . . . cord-010092-uftc8inx 789 1 Methods method NNS cord-010092-uftc8inx 789 2 : : : cord-010092-uftc8inx 790 1 The the DT cord-010092-uftc8inx 790 2 UK UK NNP cord-010092-uftc8inx 790 3 Biobank Biobank NNP cord-010092-uftc8inx 790 4 Axiom Axiom NNP cord-010092-uftc8inx 790 5 array array NN cord-010092-uftc8inx 790 6 , , , cord-010092-uftc8inx 790 7 previously previously RB cord-010092-uftc8inx 790 8 used use VBN cord-010092-uftc8inx 790 9 to to TO cord-010092-uftc8inx 790 10 type type VB cord-010092-uftc8inx 790 11 600,000 600,000 CD cord-010092-uftc8inx 790 12 UK UK NNP cord-010092-uftc8inx 790 13 citizens citizen NNS cord-010092-uftc8inx 790 14 , , , cord-010092-uftc8inx 790 15 was be VBD cord-010092-uftc8inx 790 16 redesigned redesign VBN cord-010092-uftc8inx 790 17 for for IN cord-010092-uftc8inx 790 18 donor donor NN cord-010092-uftc8inx 790 19 typing typing NN cord-010092-uftc8inx 790 20 using use VBG cord-010092-uftc8inx 790 21 three three CD cord-010092-uftc8inx 790 22 approaches approach NNS cord-010092-uftc8inx 790 23 : : : cord-010092-uftc8inx 790 24 i i LS cord-010092-uftc8inx 790 25 ) ) -RRB- cord-010092-uftc8inx 790 26 Mining mining NN cord-010092-uftc8inx 790 27 transfusion transfusion NN cord-010092-uftc8inx 790 28 medicine medicine NN cord-010092-uftc8inx 790 29 knowledge knowledge NN cord-010092-uftc8inx 790 30 , , , cord-010092-uftc8inx 790 31 e.g. e.g. RB cord-010092-uftc8inx 790 32 ISBT ISBT NNP cord-010092-uftc8inx 790 33 allele allele NN cord-010092-uftc8inx 790 34 tables table NNS cord-010092-uftc8inx 790 35 ; ; : cord-010092-uftc8inx 790 36 ii ii LS cord-010092-uftc8inx 790 37 ) ) -RRB- cord-010092-uftc8inx 790 38 Inclusion inclusion NN cord-010092-uftc8inx 790 39 of of IN cord-010092-uftc8inx 790 40 loci locus NNS cord-010092-uftc8inx 790 41 associated associate VBN cord-010092-uftc8inx 790 42 with with IN cord-010092-uftc8inx 790 43 donor donor NN cord-010092-uftc8inx 790 44 health health NN cord-010092-uftc8inx 790 45 ; ; : cord-010092-uftc8inx 790 46 iii iii LS cord-010092-uftc8inx 790 47 ) ) -RRB- cord-010092-uftc8inx 790 48 Extraction extraction NN cord-010092-uftc8inx 790 49 of of IN cord-010092-uftc8inx 790 50 all all DT cord-010092-uftc8inx 790 51 coding code VBG cord-010092-uftc8inx 790 52 variants variant NNS cord-010092-uftc8inx 790 53 in in IN cord-010092-uftc8inx 790 54 relevant relevant JJ cord-010092-uftc8inx 790 55 genes gene NNS cord-010092-uftc8inx 790 56 with with IN cord-010092-uftc8inx 790 57 a a DT cord-010092-uftc8inx 790 58 frequency frequency NN cord-010092-uftc8inx 791 1 > > XX cord-010092-uftc8inx 792 1 1:20,000 1:20,000 LS cord-010092-uftc8inx 792 2 identified identify VBN cord-010092-uftc8inx 792 3 in in IN cord-010092-uftc8inx 792 4 large large JJ cord-010092-uftc8inx 792 5 - - HYPH cord-010092-uftc8inx 792 6 scale scale NN cord-010092-uftc8inx 792 7 sequencing sequencing NN cord-010092-uftc8inx 792 8 data datum NNS cord-010092-uftc8inx 792 9 . . . cord-010092-uftc8inx 793 1 Samples sample NNS cord-010092-uftc8inx 793 2 from from IN cord-010092-uftc8inx 793 3 NHSBT NHSBT NNP cord-010092-uftc8inx 793 4 and and CC cord-010092-uftc8inx 793 5 Sanquin Sanquin NNP cord-010092-uftc8inx 793 6 blood blood NN cord-010092-uftc8inx 793 7 donors donor NNS cord-010092-uftc8inx 793 8 ( ( -LRB- cord-010092-uftc8inx 793 9 n n NN cord-010092-uftc8inx 793 10 = = SYM cord-010092-uftc8inx 793 11 7,871 7,871 CD cord-010092-uftc8inx 793 12 ) ) -RRB- cord-010092-uftc8inx 793 13 were be VBD cord-010092-uftc8inx 793 14 used use VBN cord-010092-uftc8inx 793 15 for for IN cord-010092-uftc8inx 793 16 performance performance NN cord-010092-uftc8inx 793 17 assessment assessment NN cord-010092-uftc8inx 793 18 . . . cord-010092-uftc8inx 794 1 Red red JJ cord-010092-uftc8inx 794 2 cell cell NN cord-010092-uftc8inx 794 3 and and CC cord-010092-uftc8inx 794 4 platelet platelet NN cord-010092-uftc8inx 794 5 antigens antigen NNS cord-010092-uftc8inx 794 6 for for IN cord-010092-uftc8inx 794 7 each each DT cord-010092-uftc8inx 794 8 donor donor NN cord-010092-uftc8inx 794 9 were be VBD cord-010092-uftc8inx 794 10 inferred infer VBN cord-010092-uftc8inx 794 11 from from IN cord-010092-uftc8inx 794 12 genotypes genotype NNS cord-010092-uftc8inx 794 13 using use VBG cord-010092-uftc8inx 794 14 the the DT cord-010092-uftc8inx 794 15 bloodTyper bloodtyper NN cord-010092-uftc8inx 794 16 algorithm algorithm NN cord-010092-uftc8inx 794 17 and and CC cord-010092-uftc8inx 794 18 concordance concordance NN cord-010092-uftc8inx 794 19 with with IN cord-010092-uftc8inx 794 20 clinical clinical JJ cord-010092-uftc8inx 794 21 serological serological JJ cord-010092-uftc8inx 794 22 typing typing NN cord-010092-uftc8inx 794 23 results result NNS cord-010092-uftc8inx 794 24 assessed assess VBN cord-010092-uftc8inx 794 25 . . . cord-010092-uftc8inx 795 1 Results result NNS cord-010092-uftc8inx 795 2 : : : cord-010092-uftc8inx 796 1 Concordance concordance NN cord-010092-uftc8inx 796 2 between between IN cord-010092-uftc8inx 796 3 genotypic genotypic JJ cord-010092-uftc8inx 796 4 and and CC cord-010092-uftc8inx 796 5 serological serological JJ cord-010092-uftc8inx 796 6 typing typing NN cord-010092-uftc8inx 796 7 results result NNS cord-010092-uftc8inx 796 8 was be VBD cord-010092-uftc8inx 796 9 99.9 99.9 CD cord-010092-uftc8inx 796 10 % % NN cord-010092-uftc8inx 796 11 for for IN cord-010092-uftc8inx 796 12 95,022 95,022 CD cord-010092-uftc8inx 796 13 comparisons comparison NNS cord-010092-uftc8inx 796 14 ; ; : cord-010092-uftc8inx 796 15 29 29 CD cord-010092-uftc8inx 796 16 of of IN cord-010092-uftc8inx 796 17 the the DT cord-010092-uftc8inx 796 18 89 89 CD cord-010092-uftc8inx 796 19 discrepancies discrepancy NNS cord-010092-uftc8inx 796 20 were be VBD cord-010092-uftc8inx 796 21 serologically serologically RB cord-010092-uftc8inx 796 22 negative negative JJ cord-010092-uftc8inx 796 23 and and CC cord-010092-uftc8inx 796 24 genotypically genotypically RB cord-010092-uftc8inx 796 25 positive positive JJ cord-010092-uftc8inx 796 26 for for IN cord-010092-uftc8inx 796 27 a a DT cord-010092-uftc8inx 796 28 given give VBN cord-010092-uftc8inx 796 29 antigen antigen NN cord-010092-uftc8inx 796 30 ( ( -LRB- cord-010092-uftc8inx 796 31 K K NNP cord-010092-uftc8inx 796 32 / / SYM cord-010092-uftc8inx 796 33 k k XX cord-010092-uftc8inx 796 34 , , , cord-010092-uftc8inx 796 35 Fy[a Fy[a NNP cord-010092-uftc8inx 796 36 / / SYM cord-010092-uftc8inx 796 37 b b NN cord-010092-uftc8inx 796 38 ] ] -RRB- cord-010092-uftc8inx 796 39 , , , cord-010092-uftc8inx 796 40 Lu[a Lu[a NNP cord-010092-uftc8inx 796 41 / / SYM cord-010092-uftc8inx 796 42 b b NN cord-010092-uftc8inx 796 43 ] ] -RRB- cord-010092-uftc8inx 796 44 ) ) -RRB- cord-010092-uftc8inx 796 45 . . . cord-010092-uftc8inx 797 1 In in IN cord-010092-uftc8inx 797 2 all all DT cord-010092-uftc8inx 797 3 cases case NNS cord-010092-uftc8inx 797 4 DNA dna NN cord-010092-uftc8inx 797 5 variants variant NNS cord-010092-uftc8inx 797 6 known know VBN cord-010092-uftc8inx 797 7 to to TO cord-010092-uftc8inx 797 8 modify modify VB cord-010092-uftc8inx 797 9 or or CC cord-010092-uftc8inx 797 10 weaken weaken VB cord-010092-uftc8inx 797 11 antigen antigen NN cord-010092-uftc8inx 797 12 expression expression NN cord-010092-uftc8inx 797 13 were be VBD cord-010092-uftc8inx 797 14 detected detect VBN cord-010092-uftc8inx 797 15 , , , cord-010092-uftc8inx 797 16 displaying display VBG cord-010092-uftc8inx 797 17 the the DT cord-010092-uftc8inx 797 18 power power NN cord-010092-uftc8inx 797 19 of of IN cord-010092-uftc8inx 797 20 genotyping genotype VBG cord-010092-uftc8inx 797 21 to to TO cord-010092-uftc8inx 797 22 detect detect VB cord-010092-uftc8inx 797 23 variant variant NN cord-010092-uftc8inx 797 24 ' ' `` cord-010092-uftc8inx 797 25 weak weak JJ cord-010092-uftc8inx 797 26 - - HYPH cord-010092-uftc8inx 797 27 antigen antigen NN cord-010092-uftc8inx 797 28 ' ' POS cord-010092-uftc8inx 797 29 expression expression NN cord-010092-uftc8inx 797 30 . . . cord-010092-uftc8inx 798 1 Across across IN cord-010092-uftc8inx 798 2 48 48 CD cord-010092-uftc8inx 798 3 antigens antigen NNS cord-010092-uftc8inx 798 4 for for IN cord-010092-uftc8inx 798 5 which which WDT cord-010092-uftc8inx 798 6 serology serology NN cord-010092-uftc8inx 798 7 was be VBD cord-010092-uftc8inx 798 8 available available JJ cord-010092-uftc8inx 798 9 , , , cord-010092-uftc8inx 798 10 genotyping genotype VBG cord-010092-uftc8inx 798 11 provided provide VBD cord-010092-uftc8inx 798 12 a a DT cord-010092-uftc8inx 798 13 3.6-fold 3.6-fold CD cord-010092-uftc8inx 798 14 increase increase NN cord-010092-uftc8inx 798 15 in in IN cord-010092-uftc8inx 798 16 the the DT cord-010092-uftc8inx 798 17 number number NN cord-010092-uftc8inx 798 18 of of IN cord-010092-uftc8inx 798 19 typing typing NN cord-010092-uftc8inx 798 20 results result NNS cord-010092-uftc8inx 798 21 available available JJ cord-010092-uftc8inx 798 22 per per IN cord-010092-uftc8inx 798 23 donor donor NN cord-010092-uftc8inx 798 24 ( ( -LRB- cord-010092-uftc8inx 798 25 47.9 47.9 CD cord-010092-uftc8inx 798 26 vs vs IN cord-010092-uftc8inx 798 27 13.2 13.2 CD cord-010092-uftc8inx 798 28 ) ) -RRB- cord-010092-uftc8inx 798 29 . . . cord-010092-uftc8inx 799 1 Furthermore furthermore RB cord-010092-uftc8inx 799 2 , , , cord-010092-uftc8inx 799 3 genotyping genotype VBG cord-010092-uftc8inx 799 4 provided provide VBN cord-010092-uftc8inx 799 5 data datum NNS cord-010092-uftc8inx 799 6 on on IN cord-010092-uftc8inx 799 7 an an DT cord-010092-uftc8inx 799 8 additional additional JJ cord-010092-uftc8inx 799 9 224 224 CD cord-010092-uftc8inx 799 10 clinically clinically RB cord-010092-uftc8inx 799 11 relevant relevant JJ cord-010092-uftc8inx 799 12 antigens antigen NNS cord-010092-uftc8inx 799 13 , , , cord-010092-uftc8inx 799 14 allowing allow VBG cord-010092-uftc8inx 799 15 identification identification NN cord-010092-uftc8inx 799 16 of of IN cord-010092-uftc8inx 799 17 antigen antigen NN cord-010092-uftc8inx 799 18 - - HYPH cord-010092-uftc8inx 799 19 negative negative JJ cord-010092-uftc8inx 799 20 donors donor NNS cord-010092-uftc8inx 799 21 and and CC cord-010092-uftc8inx 799 22 blood blood NN cord-010092-uftc8inx 799 23 group group NN cord-010092-uftc8inx 799 24 identification identification NN cord-010092-uftc8inx 799 25 for for IN cord-010092-uftc8inx 799 26 which which WDT cord-010092-uftc8inx 799 27 antibodies antibody NNS cord-010092-uftc8inx 799 28 are be VBP cord-010092-uftc8inx 799 29 not not RB cord-010092-uftc8inx 799 30 commercially commercially RB cord-010092-uftc8inx 799 31 available available JJ cord-010092-uftc8inx 799 32 . . . cord-010092-uftc8inx 800 1 The the DT cord-010092-uftc8inx 800 2 power power NN cord-010092-uftc8inx 800 3 of of IN cord-010092-uftc8inx 800 4 a a DT cord-010092-uftc8inx 800 5 genotyped genotype VBN cord-010092-uftc8inx 800 6 panel panel NN cord-010092-uftc8inx 800 7 of of IN cord-010092-uftc8inx 800 8 donors donor NNS cord-010092-uftc8inx 800 9 to to TO cord-010092-uftc8inx 800 10 support support VB cord-010092-uftc8inx 800 11 patient patient JJ cord-010092-uftc8inx 800 12 management management NN cord-010092-uftc8inx 800 13 was be VBD cord-010092-uftc8inx 800 14 demonstrated demonstrate VBN cord-010092-uftc8inx 800 15 by by IN cord-010092-uftc8inx 800 16 a a DT cord-010092-uftc8inx 800 17 retrospective retrospective JJ cord-010092-uftc8inx 800 18 analysis analysis NN cord-010092-uftc8inx 800 19 of of IN cord-010092-uftc8inx 800 20 clinical clinical JJ cord-010092-uftc8inx 800 21 cases case NNS cord-010092-uftc8inx 800 22 referred refer VBN cord-010092-uftc8inx 800 23 to to IN cord-010092-uftc8inx 800 24 NHSBT NHSBT NNP cord-010092-uftc8inx 800 25 . . . cord-010092-uftc8inx 801 1 From from IN cord-010092-uftc8inx 801 2 3,146 3,146 CD cord-010092-uftc8inx 801 3 patient patient NN cord-010092-uftc8inx 801 4 referrals referral NNS cord-010092-uftc8inx 801 5 with with IN cord-010092-uftc8inx 801 6 > > XX cord-010092-uftc8inx 801 7 3 3 CD cord-010092-uftc8inx 801 8 alloantibodies alloantibody NNS cord-010092-uftc8inx 801 9 between between IN cord-010092-uftc8inx 801 10 2014 2014 CD cord-010092-uftc8inx 801 11 and and CC cord-010092-uftc8inx 801 12 2018 2018 CD cord-010092-uftc8inx 801 13 , , , cord-010092-uftc8inx 801 14 772 772 CD cord-010092-uftc8inx 801 15 unique unique JJ cord-010092-uftc8inx 801 16 alloantibody alloantibody NN cord-010092-uftc8inx 801 17 profiles profile NNS cord-010092-uftc8inx 801 18 were be VBD cord-010092-uftc8inx 801 19 identified identify VBN cord-010092-uftc8inx 801 20 . . . cord-010092-uftc8inx 802 1 We -PRON- PRP cord-010092-uftc8inx 802 2 found find VBD cord-010092-uftc8inx 802 3 that that IN cord-010092-uftc8inx 802 4 there there EX cord-010092-uftc8inx 802 5 was be VBD cord-010092-uftc8inx 802 6 a a DT cord-010092-uftc8inx 802 7 2.6-fold 2.6-fold CD cord-010092-uftc8inx 802 8 greater great JJR cord-010092-uftc8inx 802 9 likelihood likelihood NN cord-010092-uftc8inx 802 10 of of IN cord-010092-uftc8inx 802 11 finding find VBG cord-010092-uftc8inx 802 12 O o NN cord-010092-uftc8inx 802 13 negative negative JJ cord-010092-uftc8inx 802 14 compatible compatible JJ cord-010092-uftc8inx 802 15 donors donor NNS cord-010092-uftc8inx 802 16 for for IN cord-010092-uftc8inx 802 17 these these DT cord-010092-uftc8inx 802 18 patients patient NNS cord-010092-uftc8inx 802 19 when when WRB cord-010092-uftc8inx 802 20 using use VBG cord-010092-uftc8inx 802 21 genotyping genotyping NN cord-010092-uftc8inx 802 22 data datum NNS cord-010092-uftc8inx 802 23 from from IN cord-010092-uftc8inx 802 24 the the DT cord-010092-uftc8inx 802 25 4,721 4,721 CD cord-010092-uftc8inx 802 26 NHSBT NHSBT NNP cord-010092-uftc8inx 802 27 donors donor NNS cord-010092-uftc8inx 802 28 . . . cord-010092-uftc8inx 803 1 Importantly importantly RB cord-010092-uftc8inx 803 2 , , , cord-010092-uftc8inx 803 3 the the DT cord-010092-uftc8inx 803 4 number number NN cord-010092-uftc8inx 803 5 of of IN cord-010092-uftc8inx 803 6 alloantibody alloantibody NN cord-010092-uftc8inx 803 7 combinations combination NNS cord-010092-uftc8inx 803 8 for for IN cord-010092-uftc8inx 803 9 which which WDT cord-010092-uftc8inx 803 10 no no DT cord-010092-uftc8inx 803 11 compatible compatible JJ cord-010092-uftc8inx 803 12 antigen antigen NN cord-010092-uftc8inx 803 13 - - HYPH cord-010092-uftc8inx 803 14 negative negative JJ cord-010092-uftc8inx 803 15 donor donor NN cord-010092-uftc8inx 803 16 could could MD cord-010092-uftc8inx 803 17 be be VB cord-010092-uftc8inx 803 18 identified identify VBN cord-010092-uftc8inx 803 19 fell fall VBD cord-010092-uftc8inx 803 20 from from IN cord-010092-uftc8inx 803 21 293 293 CD cord-010092-uftc8inx 803 22 to to IN cord-010092-uftc8inx 803 23 246 246 CD cord-010092-uftc8inx 803 24 , , , cord-010092-uftc8inx 803 25 representing represent VBG cord-010092-uftc8inx 803 26 an an DT cord-010092-uftc8inx 803 27 additional additional JJ cord-010092-uftc8inx 803 28 164 164 CD cord-010092-uftc8inx 803 29 patients patient NNS cord-010092-uftc8inx 803 30 that that WDT cord-010092-uftc8inx 803 31 could could MD cord-010092-uftc8inx 803 32 be be VB cord-010092-uftc8inx 803 33 provided provide VBN cord-010092-uftc8inx 803 34 with with IN cord-010092-uftc8inx 803 35 directly directly RB cord-010092-uftc8inx 803 36 compatible compatible JJ cord-010092-uftc8inx 803 37 blood blood NN cord-010092-uftc8inx 803 38 using use VBG cord-010092-uftc8inx 803 39 the the DT cord-010092-uftc8inx 803 40 same same JJ cord-010092-uftc8inx 803 41 donors donor NNS cord-010092-uftc8inx 803 42 . . . cord-010092-uftc8inx 804 1 Summary Summary NNP cord-010092-uftc8inx 804 2 / / SYM cord-010092-uftc8inx 804 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 804 4 : : : cord-010092-uftc8inx 804 5 Through through IN cord-010092-uftc8inx 804 6 the the DT cord-010092-uftc8inx 804 7 BGC BGC NNP cord-010092-uftc8inx 804 8 efforts effort VBZ cord-010092-uftc8inx 804 9 an an DT cord-010092-uftc8inx 804 10 affordable affordable JJ cord-010092-uftc8inx 804 11 fully fully RB cord-010092-uftc8inx 804 12 automated automate VBN cord-010092-uftc8inx 804 13 genotyping genotyping NN cord-010092-uftc8inx 804 14 platform platform NN cord-010092-uftc8inx 804 15 , , , cord-010092-uftc8inx 804 16 including include VBG cord-010092-uftc8inx 804 17 the the DT cord-010092-uftc8inx 804 18 processes process NNS cord-010092-uftc8inx 804 19 for for IN cord-010092-uftc8inx 804 20 quality quality NN cord-010092-uftc8inx 804 21 assurance assurance NN cord-010092-uftc8inx 804 22 and and CC cord-010092-uftc8inx 804 23 data datum NNS cord-010092-uftc8inx 804 24 analysis analysis NN cord-010092-uftc8inx 804 25 , , , cord-010092-uftc8inx 804 26 has have VBZ cord-010092-uftc8inx 804 27 been be VBN cord-010092-uftc8inx 804 28 developed develop VBN cord-010092-uftc8inx 804 29 . . . cord-010092-uftc8inx 805 1 Furthermore furthermore RB cord-010092-uftc8inx 805 2 , , , cord-010092-uftc8inx 805 3 we -PRON- PRP cord-010092-uftc8inx 805 4 have have VBP cord-010092-uftc8inx 805 5 demonstrated demonstrate VBN cord-010092-uftc8inx 805 6 the the DT cord-010092-uftc8inx 805 7 real real JJ cord-010092-uftc8inx 805 8 - - HYPH cord-010092-uftc8inx 805 9 world world NN cord-010092-uftc8inx 805 10 benefits benefit NNS cord-010092-uftc8inx 805 11 more more RBR cord-010092-uftc8inx 805 12 extensive extensive JJ cord-010092-uftc8inx 805 13 donor donor NN cord-010092-uftc8inx 805 14 characterisation characterisation NN cord-010092-uftc8inx 805 15 can can MD cord-010092-uftc8inx 805 16 provide provide VB cord-010092-uftc8inx 805 17 when when WRB cord-010092-uftc8inx 805 18 selecting select VBG cord-010092-uftc8inx 805 19 blood blood NN cord-010092-uftc8inx 805 20 for for IN cord-010092-uftc8inx 805 21 patients patient NNS cord-010092-uftc8inx 805 22 with with IN cord-010092-uftc8inx 805 23 multiple multiple JJ cord-010092-uftc8inx 805 24 antibodies antibody NNS cord-010092-uftc8inx 805 25 . . . cord-010092-uftc8inx 806 1 The the DT cord-010092-uftc8inx 806 2 results result NNS cord-010092-uftc8inx 806 3 of of IN cord-010092-uftc8inx 806 4 this this DT cord-010092-uftc8inx 806 5 international international JJ cord-010092-uftc8inx 806 6 collaboration collaboration NN cord-010092-uftc8inx 806 7 provide provide VB cord-010092-uftc8inx 806 8 opportunities opportunity NNS cord-010092-uftc8inx 806 9 to to TO cord-010092-uftc8inx 806 10 introduce introduce VB cord-010092-uftc8inx 806 11 fully fully RB cord-010092-uftc8inx 806 12 - - HYPH cord-010092-uftc8inx 806 13 automated automate VBN cord-010092-uftc8inx 806 14 genotype genotype NN cord-010092-uftc8inx 806 15 - - HYPH cord-010092-uftc8inx 806 16 based base VBN cord-010092-uftc8inx 806 17 donor donor NN cord-010092-uftc8inx 806 18 typing typing NN cord-010092-uftc8inx 806 19 in in IN cord-010092-uftc8inx 806 20 a a DT cord-010092-uftc8inx 806 21 safe safe JJ cord-010092-uftc8inx 806 22 and and CC cord-010092-uftc8inx 806 23 cost cost NN cord-010092-uftc8inx 806 24 - - HYPH cord-010092-uftc8inx 806 25 efficient efficient JJ cord-010092-uftc8inx 806 26 manner manner NN cord-010092-uftc8inx 806 27 in in IN cord-010092-uftc8inx 806 28 blood blood NN cord-010092-uftc8inx 806 29 supply supply NN cord-010092-uftc8inx 806 30 organisations organisation NNS cord-010092-uftc8inx 806 31 . . . cord-010092-uftc8inx 807 1 3C 3C NNP cord-010092-uftc8inx 807 2 - - HYPH cord-010092-uftc8inx 807 3 S06 S06 NNP cord-010092-uftc8inx 807 4 - - HYPH cord-010092-uftc8inx 807 5 04 04 CD cord-010092-uftc8inx 807 6 Biobank Biobank NNP cord-010092-uftc8inx 807 7 performs perform VBZ cord-010092-uftc8inx 807 8 whole whole JJ cord-010092-uftc8inx 807 9 - - HYPH cord-010092-uftc8inx 807 10 genome genome NN cord-010092-uftc8inx 807 11 sequencing sequencing NN cord-010092-uftc8inx 807 12 ( ( -LRB- cord-010092-uftc8inx 807 13 WGS WGS NNP cord-010092-uftc8inx 807 14 ) ) -RRB- cord-010092-uftc8inx 807 15 from from IN cord-010092-uftc8inx 807 16 individuals individual NNS cord-010092-uftc8inx 807 17 nation nation NN cord-010092-uftc8inx 807 18 - - HYPH cord-010092-uftc8inx 807 19 wide wide RB cord-010092-uftc8inx 807 20 . . . cord-010092-uftc8inx 808 1 These these DT cord-010092-uftc8inx 808 2 data datum NNS cord-010092-uftc8inx 808 3 are be VBP cord-010092-uftc8inx 808 4 suitable suitable JJ cord-010092-uftc8inx 808 5 for for IN cord-010092-uftc8inx 808 6 allele allele NN cord-010092-uftc8inx 808 7 frequency frequency NN cord-010092-uftc8inx 808 8 analysis analysis NN cord-010092-uftc8inx 808 9 to to TO cord-010092-uftc8inx 808 10 demonstrate demonstrate VB cord-010092-uftc8inx 808 11 gene gene NN cord-010092-uftc8inx 808 12 expression expression NN cord-010092-uftc8inx 808 13 and and CC cord-010092-uftc8inx 808 14 genetic genetic JJ cord-010092-uftc8inx 808 15 profile profile NN cord-010092-uftc8inx 808 16 in in IN cord-010092-uftc8inx 808 17 our -PRON- PRP$ cord-010092-uftc8inx 808 18 population population NN cord-010092-uftc8inx 808 19 , , , cord-010092-uftc8inx 808 20 also also RB cord-010092-uftc8inx 808 21 to to TO cord-010092-uftc8inx 808 22 estimate estimate VB cord-010092-uftc8inx 808 23 the the DT cord-010092-uftc8inx 808 24 significance significance NN cord-010092-uftc8inx 808 25 of of IN cord-010092-uftc8inx 808 26 each each DT cord-010092-uftc8inx 808 27 antigen antigen NN cord-010092-uftc8inx 808 28 in in IN cord-010092-uftc8inx 808 29 transfusion transfusion NN cord-010092-uftc8inx 808 30 practice practice NN cord-010092-uftc8inx 808 31 . . . cord-010092-uftc8inx 809 1 Aims aim VBZ cord-010092-uftc8inx 809 2 : : : cord-010092-uftc8inx 809 3 We -PRON- PRP cord-010092-uftc8inx 809 4 aim aim VBP cord-010092-uftc8inx 809 5 to to TO cord-010092-uftc8inx 809 6 provide provide VB cord-010092-uftc8inx 809 7 and and CC cord-010092-uftc8inx 809 8 verify verify VB cord-010092-uftc8inx 809 9 population population NN cord-010092-uftc8inx 809 10 - - HYPH cord-010092-uftc8inx 809 11 based base VBN cord-010092-uftc8inx 809 12 blood blood NN cord-010092-uftc8inx 809 13 group group NN cord-010092-uftc8inx 809 14 antigen antigen NN cord-010092-uftc8inx 809 15 profile profile NN cord-010092-uftc8inx 809 16 using use VBG cord-010092-uftc8inx 809 17 WGS WGS NNP cord-010092-uftc8inx 809 18 and and CC cord-010092-uftc8inx 809 19 DNA dna NN cord-010092-uftc8inx 809 20 samples sample NNS cord-010092-uftc8inx 809 21 from from IN cord-010092-uftc8inx 809 22 Taiwan Taiwan NNP cord-010092-uftc8inx 809 23 Biobank Biobank NNP cord-010092-uftc8inx 809 24 . . . cord-010092-uftc8inx 810 1 Methods method NNS cord-010092-uftc8inx 810 2 : : : cord-010092-uftc8inx 811 1 A a DT cord-010092-uftc8inx 811 2 near near JJ cord-010092-uftc8inx 811 3 1500 1500 CD cord-010092-uftc8inx 811 4 WGS WGS NNP cord-010092-uftc8inx 811 5 and and CC cord-010092-uftc8inx 811 6 demographic demographic JJ cord-010092-uftc8inx 811 7 data datum NNS cord-010092-uftc8inx 811 8 were be VBD cord-010092-uftc8inx 811 9 analyzed analyze VBN cord-010092-uftc8inx 811 10 . . . cord-010092-uftc8inx 812 1 Annotations annotation NNS cord-010092-uftc8inx 812 2 of of IN cord-010092-uftc8inx 812 3 blood blood NN cord-010092-uftc8inx 812 4 group group NN cord-010092-uftc8inx 812 5 antigen antigen NN cord-010092-uftc8inx 812 6 were be VBD cord-010092-uftc8inx 812 7 performed perform VBN cord-010092-uftc8inx 812 8 according accord VBG cord-010092-uftc8inx 812 9 to to IN cord-010092-uftc8inx 812 10 variants variant NNS cord-010092-uftc8inx 812 11 from from IN cord-010092-uftc8inx 812 12 ISBT ISBT NNP cord-010092-uftc8inx 812 13 allele allele NN cord-010092-uftc8inx 812 14 tables table NNS cord-010092-uftc8inx 812 15 , , , cord-010092-uftc8inx 812 16 including include VBG cord-010092-uftc8inx 812 17 2 2 CD cord-010092-uftc8inx 812 18 transcription transcription NN cord-010092-uftc8inx 812 19 factors factor NNS cord-010092-uftc8inx 812 20 ; ; : cord-010092-uftc8inx 812 21 variants variant NNS cord-010092-uftc8inx 812 22 for for IN cord-010092-uftc8inx 812 23 the the DT cord-010092-uftc8inx 812 24 Lewis Lewis NNP cord-010092-uftc8inx 812 25 system system NN cord-010092-uftc8inx 812 26 were be VBD cord-010092-uftc8inx 812 27 obtained obtain VBN cord-010092-uftc8inx 812 28 from from IN cord-010092-uftc8inx 812 29 previous previous JJ cord-010092-uftc8inx 812 30 studies study NNS cord-010092-uftc8inx 812 31 . . . cord-010092-uftc8inx 813 1 Annotations annotation NNS cord-010092-uftc8inx 813 2 of of IN cord-010092-uftc8inx 813 3 blood blood NN cord-010092-uftc8inx 813 4 group group NN cord-010092-uftc8inx 813 5 variants variant NNS cord-010092-uftc8inx 813 6 were be VBD cord-010092-uftc8inx 813 7 verified verify VBN cord-010092-uftc8inx 813 8 by by IN cord-010092-uftc8inx 813 9 4 4 CD cord-010092-uftc8inx 813 10 DNA dna NN cord-010092-uftc8inx 813 11 samples sample NNS cord-010092-uftc8inx 813 12 with with IN cord-010092-uftc8inx 813 13 targeted target VBN cord-010092-uftc8inx 813 14 sequencing sequencing NN cord-010092-uftc8inx 813 15 on on IN cord-010092-uftc8inx 813 16 Illumina Illumina NNP cord-010092-uftc8inx 813 17 MiSeq MiSeq NNP cord-010092-uftc8inx 813 18 , , , cord-010092-uftc8inx 813 19 and and CC cord-010092-uftc8inx 813 20 specific specific JJ cord-010092-uftc8inx 813 21 variants variant NNS cord-010092-uftc8inx 813 22 were be VBD cord-010092-uftc8inx 813 23 verified verify VBN cord-010092-uftc8inx 813 24 by by IN cord-010092-uftc8inx 813 25 40 40 CD cord-010092-uftc8inx 813 26 DNA dna NN cord-010092-uftc8inx 813 27 samples sample NNS cord-010092-uftc8inx 813 28 with with IN cord-010092-uftc8inx 813 29 the the DT cord-010092-uftc8inx 813 30 commercial commercial JJ cord-010092-uftc8inx 813 31 genotyping genotyping NN cord-010092-uftc8inx 813 32 kit kit NN cord-010092-uftc8inx 813 33 or or CC cord-010092-uftc8inx 813 34 Sanger Sanger NNP cord-010092-uftc8inx 813 35 sequencing sequencing NN cord-010092-uftc8inx 813 36 . . . cord-010092-uftc8inx 814 1 Allele allele NN cord-010092-uftc8inx 814 2 frequencies frequency NNS cord-010092-uftc8inx 814 3 from from IN cord-010092-uftc8inx 814 4 WGS WGS NNP cord-010092-uftc8inx 814 5 analysis analysis NN cord-010092-uftc8inx 814 6 were be VBD cord-010092-uftc8inx 814 7 compared compare VBN cord-010092-uftc8inx 814 8 with with IN cord-010092-uftc8inx 814 9 population population NN cord-010092-uftc8inx 814 10 serology serology NN cord-010092-uftc8inx 814 11 data datum NNS cord-010092-uftc8inx 814 12 using use VBG cord-010092-uftc8inx 814 13 two two CD cord-010092-uftc8inx 814 14 - - HYPH cord-010092-uftc8inx 814 15 proportion proportion NN cord-010092-uftc8inx 814 16 z z NN cord-010092-uftc8inx 814 17 test test NN cord-010092-uftc8inx 814 18 . . . cord-010092-uftc8inx 815 1 Results result NNS cord-010092-uftc8inx 815 2 : : : cord-010092-uftc8inx 816 1 Population population NN cord-010092-uftc8inx 816 2 - - HYPH cord-010092-uftc8inx 816 3 wide wide JJ cord-010092-uftc8inx 816 4 blood blood NN cord-010092-uftc8inx 816 5 group group NN cord-010092-uftc8inx 816 6 antigens antigen NNS cord-010092-uftc8inx 816 7 were be VBD cord-010092-uftc8inx 816 8 analyzed analyze VBN cord-010092-uftc8inx 816 9 , , , cord-010092-uftc8inx 816 10 revealed reveal VBN cord-010092-uftc8inx 816 11 in in IN cord-010092-uftc8inx 816 12 - - HYPH cord-010092-uftc8inx 816 13 depth depth NN cord-010092-uftc8inx 816 14 antigen antigen NN cord-010092-uftc8inx 816 15 expression expression NN cord-010092-uftc8inx 816 16 profiles profile NNS cord-010092-uftc8inx 816 17 in in IN cord-010092-uftc8inx 816 18 all all DT cord-010092-uftc8inx 816 19 systems system NNS cord-010092-uftc8inx 816 20 ( ( -LRB- cord-010092-uftc8inx 816 21 except except IN cord-010092-uftc8inx 816 22 CH CH NNP cord-010092-uftc8inx 816 23 / / SYM cord-010092-uftc8inx 816 24 RG RG NNP cord-010092-uftc8inx 816 25 ) ) -RRB- cord-010092-uftc8inx 816 26 . . . cord-010092-uftc8inx 817 1 The the DT cord-010092-uftc8inx 817 2 antigen antigen NN cord-010092-uftc8inx 817 3 frequencies frequency NNS cord-010092-uftc8inx 817 4 from from IN cord-010092-uftc8inx 817 5 WGS WGS NNP cord-010092-uftc8inx 817 6 were be VBD cord-010092-uftc8inx 817 7 similar similar JJ cord-010092-uftc8inx 817 8 compared compare VBN cord-010092-uftc8inx 817 9 with with IN cord-010092-uftc8inx 817 10 published published JJ cord-010092-uftc8inx 817 11 serology serology NN cord-010092-uftc8inx 817 12 data datum NNS cord-010092-uftc8inx 817 13 , , , cord-010092-uftc8inx 817 14 except except IN cord-010092-uftc8inx 817 15 for for IN cord-010092-uftc8inx 817 16 the the DT cord-010092-uftc8inx 817 17 antigens antigen NNS cord-010092-uftc8inx 817 18 and and CC cord-010092-uftc8inx 817 19 possible possible JJ cord-010092-uftc8inx 817 20 explanations explanation NNS cord-010092-uftc8inx 817 21 listed list VBN cord-010092-uftc8inx 817 22 as as IN cord-010092-uftc8inx 817 23 follow follow NN cord-010092-uftc8inx 817 24 , , , cord-010092-uftc8inx 817 25 1 1 CD cord-010092-uftc8inx 817 26 ) ) -RRB- cord-010092-uftc8inx 817 27 M M NNP cord-010092-uftc8inx 817 28 , , , cord-010092-uftc8inx 817 29 N n CD cord-010092-uftc8inx 817 30 : : : cord-010092-uftc8inx 817 31 insufficient insufficient JJ cord-010092-uftc8inx 817 32 sequencing sequencing NN cord-010092-uftc8inx 817 33 reads read NNS cord-010092-uftc8inx 817 34 , , , cord-010092-uftc8inx 817 35 2 2 CD cord-010092-uftc8inx 817 36 ) ) -RRB- cord-010092-uftc8inx 817 37 C C NNP cord-010092-uftc8inx 817 38 , , , cord-010092-uftc8inx 817 39 c c NN cord-010092-uftc8inx 817 40 : : : cord-010092-uftc8inx 817 41 identical identical JJ cord-010092-uftc8inx 817 42 RHCE RHCE NNP cord-010092-uftc8inx 817 43 exon exon NN cord-010092-uftc8inx 817 44 2 2 CD cord-010092-uftc8inx 817 45 with with IN cord-010092-uftc8inx 817 46 RHD RHD NNP cord-010092-uftc8inx 817 47 exon exon NN cord-010092-uftc8inx 817 48 2 2 CD cord-010092-uftc8inx 817 49 for for IN cord-010092-uftc8inx 817 50 C C NNP cord-010092-uftc8inx 817 51 allele allele NN cord-010092-uftc8inx 817 52 , , , cord-010092-uftc8inx 817 53 3 3 CD cord-010092-uftc8inx 818 1 ) ) -RRB- cord-010092-uftc8inx 818 2 Mur Mur NNP cord-010092-uftc8inx 818 3 : : : cord-010092-uftc8inx 818 4 insufficient insufficient JJ cord-010092-uftc8inx 818 5 read read NN cord-010092-uftc8inx 818 6 length length NN cord-010092-uftc8inx 818 7 / / SYM cord-010092-uftc8inx 818 8 depth depth NN cord-010092-uftc8inx 818 9 for for IN cord-010092-uftc8inx 818 10 GYPA GYPA NNP cord-010092-uftc8inx 818 11 / / SYM cord-010092-uftc8inx 818 12 GYPB gypb NN cord-010092-uftc8inx 818 13 hybridization hybridization NN cord-010092-uftc8inx 818 14 calling calling NN cord-010092-uftc8inx 818 15 and and CC cord-010092-uftc8inx 818 16 individuals individual NNS cord-010092-uftc8inx 818 17 from from IN cord-010092-uftc8inx 818 18 high high JJ cord-010092-uftc8inx 818 19 prevalence prevalence NN cord-010092-uftc8inx 818 20 of of IN cord-010092-uftc8inx 818 21 Mur Mur NNP cord-010092-uftc8inx 818 22 antigen antigen NN cord-010092-uftc8inx 818 23 in in IN cord-010092-uftc8inx 818 24 aboriginal aboriginal JJ cord-010092-uftc8inx 818 25 tribes tribe NNS cord-010092-uftc8inx 818 26 were be VBD cord-010092-uftc8inx 818 27 not not RB cord-010092-uftc8inx 818 28 enrolled enrol VBN cord-010092-uftc8inx 818 29 . . . cord-010092-uftc8inx 819 1 Blood blood NN cord-010092-uftc8inx 819 2 group group NN cord-010092-uftc8inx 819 3 antigen antigen NN cord-010092-uftc8inx 819 4 predictions prediction NNS cord-010092-uftc8inx 819 5 and and CC cord-010092-uftc8inx 819 6 variants variant NNS cord-010092-uftc8inx 819 7 from from IN cord-010092-uftc8inx 819 8 WGS WGS NNP cord-010092-uftc8inx 819 9 were be VBD cord-010092-uftc8inx 819 10 accord accord NN cord-010092-uftc8inx 819 11 to to IN cord-010092-uftc8inx 819 12 DNA dna NN cord-010092-uftc8inx 819 13 verification verification NN cord-010092-uftc8inx 819 14 . . . cord-010092-uftc8inx 820 1 Furthermore furthermore RB cord-010092-uftc8inx 820 2 , , , cord-010092-uftc8inx 820 3 13 13 CD cord-010092-uftc8inx 820 4 systems system NNS cord-010092-uftc8inx 820 5 shown show VBN cord-010092-uftc8inx 820 6 no no DT cord-010092-uftc8inx 820 7 genetic genetic JJ cord-010092-uftc8inx 820 8 variations variation NNS cord-010092-uftc8inx 820 9 , , , cord-010092-uftc8inx 820 10 predicting predict VBG cord-010092-uftc8inx 820 11 uniform uniform JJ cord-010092-uftc8inx 820 12 antigen antigen NN cord-010092-uftc8inx 820 13 expression expression NN cord-010092-uftc8inx 820 14 in in IN cord-010092-uftc8inx 820 15 our -PRON- PRP$ cord-010092-uftc8inx 820 16 population population NN cord-010092-uftc8inx 820 17 , , , cord-010092-uftc8inx 820 18 and and CC cord-010092-uftc8inx 820 19 we -PRON- PRP cord-010092-uftc8inx 820 20 can can MD cord-010092-uftc8inx 820 21 manage manage VB cord-010092-uftc8inx 820 22 transfusion transfusion NN cord-010092-uftc8inx 820 23 with with IN cord-010092-uftc8inx 820 24 minimum minimum JJ cord-010092-uftc8inx 820 25 concerns concern NNS cord-010092-uftc8inx 820 26 for for IN cord-010092-uftc8inx 820 27 antigen antigen NN cord-010092-uftc8inx 820 28 mismatch mismatch NN cord-010092-uftc8inx 820 29 in in IN cord-010092-uftc8inx 820 30 these these DT cord-010092-uftc8inx 820 31 systems system NNS cord-010092-uftc8inx 820 32 . . . cord-010092-uftc8inx 821 1 Moreover moreover RB cord-010092-uftc8inx 821 2 , , , cord-010092-uftc8inx 821 3 we -PRON- PRP cord-010092-uftc8inx 821 4 found find VBD cord-010092-uftc8inx 821 5 weak weak JJ cord-010092-uftc8inx 821 6 and and CC cord-010092-uftc8inx 821 7 null null JJ cord-010092-uftc8inx 821 8 alleles allele NNS cord-010092-uftc8inx 821 9 in in IN cord-010092-uftc8inx 821 10 our -PRON- PRP$ cord-010092-uftc8inx 821 11 population population NN cord-010092-uftc8inx 821 12 for for IN cord-010092-uftc8inx 821 13 blood blood NN cord-010092-uftc8inx 821 14 group group NN cord-010092-uftc8inx 821 15 systems system NNS cord-010092-uftc8inx 821 16 that that WDT cord-010092-uftc8inx 821 17 we -PRON- PRP cord-010092-uftc8inx 821 18 had have VBD cord-010092-uftc8inx 821 19 previously previously RB cord-010092-uftc8inx 821 20 no no DT cord-010092-uftc8inx 821 21 knowledge knowledge NN cord-010092-uftc8inx 821 22 of of IN cord-010092-uftc8inx 821 23 , , , cord-010092-uftc8inx 821 24 such such JJ cord-010092-uftc8inx 821 25 as as IN cord-010092-uftc8inx 821 26 LAN LAN NNP cord-010092-uftc8inx 821 27 , , , cord-010092-uftc8inx 821 28 JR JR NNP cord-010092-uftc8inx 821 29 , , , cord-010092-uftc8inx 821 30 and and CC cord-010092-uftc8inx 821 31 VEL VEL NNP cord-010092-uftc8inx 821 32 . . . cord-010092-uftc8inx 822 1 These these DT cord-010092-uftc8inx 822 2 variants variant NNS cord-010092-uftc8inx 822 3 were be VBD cord-010092-uftc8inx 822 4 helped help VBN cord-010092-uftc8inx 822 5 to to TO cord-010092-uftc8inx 822 6 identify identify VB cord-010092-uftc8inx 822 7 a a DT cord-010092-uftc8inx 822 8 patient patient NN cord-010092-uftc8inx 822 9 with with IN cord-010092-uftc8inx 822 10 anti anti JJ cord-010092-uftc8inx 822 11 - - NNP cord-010092-uftc8inx 822 12 Jr Jr NNP cord-010092-uftc8inx 822 13 a a DT cord-010092-uftc8inx 822 14 carrying carry VBG cord-010092-uftc8inx 822 15 homozygous homozygous JJ cord-010092-uftc8inx 822 16 Jr Jr NNP cord-010092-uftc8inx 822 17 a a DT cord-010092-uftc8inx 822 18 null null JJ cord-010092-uftc8inx 822 19 alleles allele NNS cord-010092-uftc8inx 822 20 . . . cord-010092-uftc8inx 823 1 Summary Summary NNP cord-010092-uftc8inx 823 2 / / SYM cord-010092-uftc8inx 823 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 823 4 : : : cord-010092-uftc8inx 824 1 Taiwan Taiwan NNP cord-010092-uftc8inx 824 2 Biobank Biobank NNP cord-010092-uftc8inx 824 3 WGS WGS NNP cord-010092-uftc8inx 824 4 is be VBZ cord-010092-uftc8inx 824 5 suitable suitable JJ cord-010092-uftc8inx 824 6 for for IN cord-010092-uftc8inx 824 7 full full JJ cord-010092-uftc8inx 824 8 blood blood NN cord-010092-uftc8inx 824 9 group group NN cord-010092-uftc8inx 824 10 antigen antigen NN cord-010092-uftc8inx 824 11 profile profile NN cord-010092-uftc8inx 824 12 determination determination NN cord-010092-uftc8inx 824 13 with with IN cord-010092-uftc8inx 824 14 few few JJ cord-010092-uftc8inx 824 15 adjustments adjustment NNS cord-010092-uftc8inx 824 16 required require VBN cord-010092-uftc8inx 824 17 for for IN cord-010092-uftc8inx 824 18 specific specific JJ cord-010092-uftc8inx 824 19 antigens antigen NNS cord-010092-uftc8inx 824 20 . . . cord-010092-uftc8inx 825 1 The the DT cord-010092-uftc8inx 825 2 population population NN cord-010092-uftc8inx 825 3 antigen antigen NN cord-010092-uftc8inx 825 4 allele allele NN cord-010092-uftc8inx 825 5 frequency frequency NN cord-010092-uftc8inx 825 6 provides provide VBZ cord-010092-uftc8inx 825 7 valuable valuable JJ cord-010092-uftc8inx 825 8 insight insight NN cord-010092-uftc8inx 825 9 to to TO cord-010092-uftc8inx 825 10 antigen antigen NN cord-010092-uftc8inx 825 11 significance significance NN cord-010092-uftc8inx 825 12 in in IN cord-010092-uftc8inx 825 13 transfusion transfusion NN cord-010092-uftc8inx 825 14 practice practice NN cord-010092-uftc8inx 825 15 , , , cord-010092-uftc8inx 825 16 matching match VBG cord-010092-uftc8inx 825 17 strategy strategy NN cord-010092-uftc8inx 825 18 for for IN cord-010092-uftc8inx 825 19 our -PRON- PRP$ cord-010092-uftc8inx 825 20 patients patient NNS cord-010092-uftc8inx 825 21 , , , cord-010092-uftc8inx 825 22 and and CC cord-010092-uftc8inx 825 23 estimation estimation NN cord-010092-uftc8inx 825 24 of of IN cord-010092-uftc8inx 825 25 the the DT cord-010092-uftc8inx 825 26 likelihood likelihood NN cord-010092-uftc8inx 825 27 to to TO cord-010092-uftc8inx 825 28 obtain obtain VB cord-010092-uftc8inx 825 29 for for IN cord-010092-uftc8inx 825 30 specific specific JJ cord-010092-uftc8inx 825 31 antigen antigen NN cord-010092-uftc8inx 825 32 negative negative JJ cord-010092-uftc8inx 825 33 blood blood NN cord-010092-uftc8inx 825 34 from from IN cord-010092-uftc8inx 825 35 mass mass JJ cord-010092-uftc8inx 825 36 population population NN cord-010092-uftc8inx 825 37 . . . cord-010092-uftc8inx 826 1 Also also RB cord-010092-uftc8inx 826 2 , , , cord-010092-uftc8inx 826 3 the the DT cord-010092-uftc8inx 826 4 genetic genetic JJ cord-010092-uftc8inx 826 5 variants variant NNS cord-010092-uftc8inx 826 6 revealed reveal VBN cord-010092-uftc8inx 826 7 in in IN cord-010092-uftc8inx 826 8 this this DT cord-010092-uftc8inx 826 9 study study NN cord-010092-uftc8inx 826 10 can can MD cord-010092-uftc8inx 826 11 help help VB cord-010092-uftc8inx 826 12 us -PRON- PRP cord-010092-uftc8inx 826 13 to to TO cord-010092-uftc8inx 826 14 locate locate VB cord-010092-uftc8inx 826 15 rare rare JJ cord-010092-uftc8inx 826 16 donors donor NNS cord-010092-uftc8inx 826 17 , , , cord-010092-uftc8inx 826 18 and and CC cord-010092-uftc8inx 826 19 to to TO cord-010092-uftc8inx 826 20 integrate integrate VB cord-010092-uftc8inx 826 21 variations variation NNS cord-010092-uftc8inx 826 22 into into IN cord-010092-uftc8inx 826 23 routine routine JJ cord-010092-uftc8inx 826 24 donor donor NN cord-010092-uftc8inx 826 25 blood blood NN cord-010092-uftc8inx 826 26 group group NN cord-010092-uftc8inx 826 27 screening screening NN cord-010092-uftc8inx 826 28 to to TO cord-010092-uftc8inx 826 29 provide provide VB cord-010092-uftc8inx 826 30 suitable suitable JJ cord-010092-uftc8inx 826 31 blood blood NN cord-010092-uftc8inx 826 32 at at IN cord-010092-uftc8inx 826 33 a a DT cord-010092-uftc8inx 826 34 low low JJ cord-010092-uftc8inx 826 35 cost cost NN cord-010092-uftc8inx 826 36 efficiently efficiently RB cord-010092-uftc8inx 826 37 . . . cord-010092-uftc8inx 827 1 Background background NN cord-010092-uftc8inx 827 2 : : : cord-010092-uftc8inx 828 1 Providing provide VBG cord-010092-uftc8inx 828 2 adequate adequate JJ cord-010092-uftc8inx 828 3 amounts amount NNS cord-010092-uftc8inx 828 4 of of IN cord-010092-uftc8inx 828 5 safe safe JJ cord-010092-uftc8inx 828 6 , , , cord-010092-uftc8inx 828 7 appropriately appropriately RB cord-010092-uftc8inx 828 8 matched match VBN cord-010092-uftc8inx 828 9 blood blood NN cord-010092-uftc8inx 828 10 to to TO cord-010092-uftc8inx 828 11 meet meet VB cord-010092-uftc8inx 828 12 the the DT cord-010092-uftc8inx 828 13 demands demand NNS cord-010092-uftc8inx 828 14 of of IN cord-010092-uftc8inx 828 15 an an DT cord-010092-uftc8inx 828 16 expanding expand VBG cord-010092-uftc8inx 828 17 and and CC cord-010092-uftc8inx 828 18 aging age VBG cord-010092-uftc8inx 828 19 patient patient JJ cord-010092-uftc8inx 828 20 population population NN cord-010092-uftc8inx 828 21 presents present VBZ cord-010092-uftc8inx 828 22 a a DT cord-010092-uftc8inx 828 23 challenging challenging JJ cord-010092-uftc8inx 828 24 global global JJ cord-010092-uftc8inx 828 25 problem problem NN cord-010092-uftc8inx 828 26 . . . cord-010092-uftc8inx 829 1 For for IN cord-010092-uftc8inx 829 2 these these DT cord-010092-uftc8inx 829 3 reasons reason NNS cord-010092-uftc8inx 829 4 , , , cord-010092-uftc8inx 829 5 sustainable sustainable JJ cord-010092-uftc8inx 829 6 in in FW cord-010092-uftc8inx 829 7 vitro vitro FW cord-010092-uftc8inx 829 8 sources source NNS cord-010092-uftc8inx 829 9 of of IN cord-010092-uftc8inx 829 10 red red JJ cord-010092-uftc8inx 829 11 cells cell NNS cord-010092-uftc8inx 829 12 may may MD cord-010092-uftc8inx 829 13 offer offer VB cord-010092-uftc8inx 829 14 a a DT cord-010092-uftc8inx 829 15 desirable desirable JJ cord-010092-uftc8inx 829 16 alternative alternative NN cord-010092-uftc8inx 829 17 to to IN cord-010092-uftc8inx 829 18 reliance reliance NN cord-010092-uftc8inx 829 19 on on IN cord-010092-uftc8inx 829 20 donor donor NN cord-010092-uftc8inx 829 21 blood blood NN cord-010092-uftc8inx 829 22 . . . cord-010092-uftc8inx 830 1 The the DT cord-010092-uftc8inx 830 2 first first JJ cord-010092-uftc8inx 830 3 stable stable NN cord-010092-uftc8inx 830 4 immortalized immortalize VBN cord-010092-uftc8inx 830 5 early early JJ cord-010092-uftc8inx 830 6 adult adult NN cord-010092-uftc8inx 830 7 erythroblast erythroblast NN cord-010092-uftc8inx 830 8 cell cell NN cord-010092-uftc8inx 830 9 line line NN cord-010092-uftc8inx 830 10 , , , cord-010092-uftc8inx 830 11 BEL BEL NNP cord-010092-uftc8inx 830 12 - - HYPH cord-010092-uftc8inx 830 13 A2 A2 NNP cord-010092-uftc8inx 830 14 , , , cord-010092-uftc8inx 830 15 has have VBZ cord-010092-uftc8inx 830 16 been be VBN cord-010092-uftc8inx 830 17 shown show VBN cord-010092-uftc8inx 830 18 to to TO cord-010092-uftc8inx 830 19 differentiate differentiate VB cord-010092-uftc8inx 830 20 efficiently efficiently RB cord-010092-uftc8inx 830 21 into into IN cord-010092-uftc8inx 830 22 mature mature JJ cord-010092-uftc8inx 830 23 , , , cord-010092-uftc8inx 830 24 functional functional JJ cord-010092-uftc8inx 830 25 reticulocytes reticulocyte NNS cord-010092-uftc8inx 831 1 ( ( -LRB- cord-010092-uftc8inx 831 2 Trakarnsanga Trakarnsanga NNP cord-010092-uftc8inx 831 3 et et FW cord-010092-uftc8inx 831 4 al al NNP cord-010092-uftc8inx 831 5 . . . cord-010092-uftc8inx 832 1 , , , cord-010092-uftc8inx 832 2 Nat Nat NNP cord-010092-uftc8inx 832 3 Commun Commun NNP cord-010092-uftc8inx 832 4 . . . cord-010092-uftc8inx 833 1 8:14750 8:14750 CD cord-010092-uftc8inx 833 2 , , , cord-010092-uftc8inx 833 3 2017 2017 CD cord-010092-uftc8inx 833 4 ) ) -RRB- cord-010092-uftc8inx 834 1 and and CC cord-010092-uftc8inx 834 2 consequently consequently RB cord-010092-uftc8inx 834 3 could could MD cord-010092-uftc8inx 834 4 provide provide VB cord-010092-uftc8inx 834 5 a a DT cord-010092-uftc8inx 834 6 readily readily RB cord-010092-uftc8inx 834 7 available available JJ cord-010092-uftc8inx 834 8 tool tool NN cord-010092-uftc8inx 834 9 for for IN cord-010092-uftc8inx 834 10 diagnostic diagnostic JJ cord-010092-uftc8inx 834 11 use use NN cord-010092-uftc8inx 834 12 and and CC cord-010092-uftc8inx 834 13 proof proof NN cord-010092-uftc8inx 834 14 of of IN cord-010092-uftc8inx 834 15 principle principle NN cord-010092-uftc8inx 834 16 for for IN cord-010092-uftc8inx 834 17 future future JJ cord-010092-uftc8inx 834 18 therapeutic therapeutic JJ cord-010092-uftc8inx 834 19 use use NN cord-010092-uftc8inx 834 20 . . . cord-010092-uftc8inx 835 1 Aims aim VBZ cord-010092-uftc8inx 835 2 : : : cord-010092-uftc8inx 836 1 At at IN cord-010092-uftc8inx 836 2 IBGRL IBGRL NNP cord-010092-uftc8inx 836 3 , , , cord-010092-uftc8inx 836 4 next next JJ cord-010092-uftc8inx 836 5 generation generation NN cord-010092-uftc8inx 836 6 whole whole JJ cord-010092-uftc8inx 836 7 exome exome NN cord-010092-uftc8inx 836 8 sequencing sequencing NN cord-010092-uftc8inx 836 9 ( ( -LRB- cord-010092-uftc8inx 836 10 WES WES NNP cord-010092-uftc8inx 836 11 ) ) -RRB- cord-010092-uftc8inx 836 12 has have VBZ cord-010092-uftc8inx 836 13 been be VBN cord-010092-uftc8inx 836 14 used use VBN cord-010092-uftc8inx 836 15 previously previously RB cord-010092-uftc8inx 836 16 to to TO cord-010092-uftc8inx 836 17 accurately accurately RB cord-010092-uftc8inx 836 18 predict predict VB cord-010092-uftc8inx 836 19 blood blood NN cord-010092-uftc8inx 836 20 group group NN cord-010092-uftc8inx 836 21 phenotype phenotype NN cord-010092-uftc8inx 836 22 in in IN cord-010092-uftc8inx 836 23 a a DT cord-010092-uftc8inx 836 24 number number NN cord-010092-uftc8inx 836 25 of of IN cord-010092-uftc8inx 836 26 blood blood NN cord-010092-uftc8inx 836 27 group group NN cord-010092-uftc8inx 836 28 systems system NNS cord-010092-uftc8inx 836 29 , , , cord-010092-uftc8inx 836 30 including include VBG cord-010092-uftc8inx 836 31 ABO ABO NNP cord-010092-uftc8inx 836 32 , , , cord-010092-uftc8inx 836 33 Rh Rh NNP cord-010092-uftc8inx 836 34 and and CC cord-010092-uftc8inx 836 35 MNS MNS NNP cord-010092-uftc8inx 836 36 ( ( -LRB- cord-010092-uftc8inx 836 37 Tilley Tilley NNP cord-010092-uftc8inx 836 38 & & CC cord-010092-uftc8inx 836 39 Thornton Thornton NNP cord-010092-uftc8inx 836 40 , , , cord-010092-uftc8inx 836 41 Transfusion Transfusion NNP cord-010092-uftc8inx 836 42 Medicine Medicine NNP cord-010092-uftc8inx 836 43 27 27 CD cord-010092-uftc8inx 836 44 ( ( -LRB- cord-010092-uftc8inx 836 45 Suppl.2 Suppl.2 NNP cord-010092-uftc8inx 836 46 ) ) -RRB- cord-010092-uftc8inx 836 47 : : : cord-010092-uftc8inx 836 48 42 42 CD cord-010092-uftc8inx 836 49 , , , cord-010092-uftc8inx 836 50 2017 2017 CD cord-010092-uftc8inx 836 51 ) ) -RRB- cord-010092-uftc8inx 836 52 . . . cord-010092-uftc8inx 837 1 Here here RB cord-010092-uftc8inx 837 2 we -PRON- PRP cord-010092-uftc8inx 837 3 have have VBP cord-010092-uftc8inx 837 4 used use VBN cord-010092-uftc8inx 837 5 it -PRON- PRP cord-010092-uftc8inx 837 6 to to TO cord-010092-uftc8inx 837 7 analyse analyse VB cord-010092-uftc8inx 837 8 and and CC cord-010092-uftc8inx 837 9 document document VB cord-010092-uftc8inx 837 10 BEL BEL NNP cord-010092-uftc8inx 837 11 - - HYPH cord-010092-uftc8inx 837 12 A2 A2 NNP cord-010092-uftc8inx 837 13 blood blood NN cord-010092-uftc8inx 837 14 group group NN cord-010092-uftc8inx 837 15 - - HYPH cord-010092-uftc8inx 837 16 related relate VBN cord-010092-uftc8inx 837 17 genotypes genotype NNS cord-010092-uftc8inx 837 18 and and CC cord-010092-uftc8inx 837 19 predict predict VB cord-010092-uftc8inx 837 20 blood blood NN cord-010092-uftc8inx 837 21 group group NN cord-010092-uftc8inx 837 22 phenotypes phenotype NNS cord-010092-uftc8inx 837 23 . . . cord-010092-uftc8inx 838 1 Additional additional JJ cord-010092-uftc8inx 838 2 genes gene NNS cord-010092-uftc8inx 838 3 involved involve VBN cord-010092-uftc8inx 838 4 in in IN cord-010092-uftc8inx 838 5 cell cell NN cord-010092-uftc8inx 838 6 - - HYPH cord-010092-uftc8inx 838 7 growth growth NN cord-010092-uftc8inx 838 8 and and CC cord-010092-uftc8inx 838 9 enucleation enucleation NN cord-010092-uftc8inx 838 10 were be VBD cord-010092-uftc8inx 838 11 also also RB cord-010092-uftc8inx 838 12 analysed analyse VBN cord-010092-uftc8inx 838 13 in in IN cord-010092-uftc8inx 838 14 order order NN cord-010092-uftc8inx 838 15 to to TO cord-010092-uftc8inx 838 16 further further RB cord-010092-uftc8inx 838 17 elucidate elucidate VB cord-010092-uftc8inx 838 18 the the DT cord-010092-uftc8inx 838 19 characteristics characteristic NNS cord-010092-uftc8inx 838 20 of of IN cord-010092-uftc8inx 838 21 the the DT cord-010092-uftc8inx 838 22 BEL BEL NNP cord-010092-uftc8inx 838 23 - - HYPH cord-010092-uftc8inx 838 24 A2 A2 NNP cord-010092-uftc8inx 838 25 cell cell NN cord-010092-uftc8inx 838 26 - - HYPH cord-010092-uftc8inx 838 27 line line NN cord-010092-uftc8inx 838 28 . . . cord-010092-uftc8inx 839 1 Methods method NNS cord-010092-uftc8inx 839 2 : : : cord-010092-uftc8inx 839 3 BEL BEL NNP cord-010092-uftc8inx 839 4 - - HYPH cord-010092-uftc8inx 839 5 A2 A2 NNP cord-010092-uftc8inx 839 6 cells cell NNS cord-010092-uftc8inx 839 7 ( ( -LRB- cord-010092-uftc8inx 839 8 day day NN cord-010092-uftc8inx 839 9 196 196 CD cord-010092-uftc8inx 839 10 ) ) -RRB- cord-010092-uftc8inx 839 11 were be VBD cord-010092-uftc8inx 839 12 cultured culture VBN cord-010092-uftc8inx 839 13 in in IN cord-010092-uftc8inx 839 14 expansion expansion NN cord-010092-uftc8inx 839 15 medium medium NN cord-010092-uftc8inx 839 16 and and CC cord-010092-uftc8inx 839 17 genomic genomic JJ cord-010092-uftc8inx 839 18 DNA dna NN cord-010092-uftc8inx 839 19 ( ( -LRB- cord-010092-uftc8inx 839 20 gDNA gDNA NNP cord-010092-uftc8inx 839 21 ) ) -RRB- cord-010092-uftc8inx 839 22 was be VBD cord-010092-uftc8inx 839 23 isolated isolate VBN cord-010092-uftc8inx 839 24 from from IN cord-010092-uftc8inx 839 25 1 1 CD cord-010092-uftc8inx 839 26 9 9 CD cord-010092-uftc8inx 839 27 10 10 CD cord-010092-uftc8inx 839 28 6 6 CD cord-010092-uftc8inx 839 29 cells cell NNS cord-010092-uftc8inx 839 30 on on IN cord-010092-uftc8inx 839 31 day day NN cord-010092-uftc8inx 839 32 5 5 CD cord-010092-uftc8inx 839 33 . . . cord-010092-uftc8inx 840 1 For for IN cord-010092-uftc8inx 840 2 WES WES NNP cord-010092-uftc8inx 840 3 , , , cord-010092-uftc8inx 840 4 gDNA gdna NN cord-010092-uftc8inx 840 5 libraries library NNS cord-010092-uftc8inx 840 6 were be VBD cord-010092-uftc8inx 840 7 prepared prepare VBN cord-010092-uftc8inx 840 8 using use VBG cord-010092-uftc8inx 840 9 Nextera Nextera NNP cord-010092-uftc8inx 840 10 â â . cord-010092-uftc8inx 840 11 Rapid Rapid NNP cord-010092-uftc8inx 840 12 Capture Capture NNP cord-010092-uftc8inx 840 13 Exome Exome NNP cord-010092-uftc8inx 840 14 enrichment enrichment NN cord-010092-uftc8inx 840 15 and and CC cord-010092-uftc8inx 840 16 sequenced sequence VBN cord-010092-uftc8inx 840 17 on on IN cord-010092-uftc8inx 840 18 Illumina Illumina NNP cord-010092-uftc8inx 840 19 â â NNP cord-010092-uftc8inx 840 20 MiSeq MiSeq NNP cord-010092-uftc8inx 840 21 . . . cord-010092-uftc8inx 841 1 Sequence sequence NN cord-010092-uftc8inx 841 2 alignments alignment NNS cord-010092-uftc8inx 841 3 for for IN cord-010092-uftc8inx 841 4 41 41 CD cord-010092-uftc8inx 841 5 genes gene NNS cord-010092-uftc8inx 841 6 encoding encode VBG cord-010092-uftc8inx 841 7 all all DT cord-010092-uftc8inx 841 8 36 36 CD cord-010092-uftc8inx 841 9 known know VBN cord-010092-uftc8inx 841 10 blood blood NN cord-010092-uftc8inx 841 11 group group NN cord-010092-uftc8inx 841 12 systems system NNS cord-010092-uftc8inx 841 13 and and CC cord-010092-uftc8inx 841 14 12 12 CD cord-010092-uftc8inx 841 15 further further JJ cord-010092-uftc8inx 841 16 genes gene NNS cord-010092-uftc8inx 841 17 encoding encode VBG cord-010092-uftc8inx 841 18 transcription transcription NN cord-010092-uftc8inx 841 19 factors factor NNS cord-010092-uftc8inx 841 20 and and CC cord-010092-uftc8inx 841 21 cell cell NN cord-010092-uftc8inx 841 22 enucleation enucleation NN cord-010092-uftc8inx 841 23 - - HYPH cord-010092-uftc8inx 841 24 associated associate VBN cord-010092-uftc8inx 841 25 proteins protein NNS cord-010092-uftc8inx 841 26 were be VBD cord-010092-uftc8inx 841 27 visualised visualise VBN cord-010092-uftc8inx 841 28 using use VBG cord-010092-uftc8inx 841 29 Integrative Integrative NNP cord-010092-uftc8inx 841 30 Genomics Genomics NNPS cord-010092-uftc8inx 841 31 Viewer Viewer NNP cord-010092-uftc8inx 841 32 , , , cord-010092-uftc8inx 841 33 whilst whilst IN cord-010092-uftc8inx 841 34 Illumina Illumina NNP cord-010092-uftc8inx 841 35 â â NNP cord-010092-uftc8inx 841 36 Variant Variant NNP cord-010092-uftc8inx 841 37 Studio Studio NNP cord-010092-uftc8inx 841 38 was be VBD cord-010092-uftc8inx 841 39 used use VBN cord-010092-uftc8inx 841 40 to to TO cord-010092-uftc8inx 841 41 identify identify VB cord-010092-uftc8inx 841 42 observed observed JJ cord-010092-uftc8inx 841 43 mutations mutation NNS cord-010092-uftc8inx 841 44 . . . cord-010092-uftc8inx 842 1 Mutations mutation NNS cord-010092-uftc8inx 842 2 in in IN cord-010092-uftc8inx 842 3 coding code VBG cord-010092-uftc8inx 842 4 regions region NNS cord-010092-uftc8inx 842 5 were be VBD cord-010092-uftc8inx 842 6 used use VBN cord-010092-uftc8inx 842 7 to to TO cord-010092-uftc8inx 842 8 determine determine VB cord-010092-uftc8inx 842 9 BEL BEL NNP cord-010092-uftc8inx 842 10 - - HYPH cord-010092-uftc8inx 842 11 A2 A2 NNP cord-010092-uftc8inx 842 12 genotype genotype NN cord-010092-uftc8inx 842 13 and and CC cord-010092-uftc8inx 842 14 predicted predict VBD cord-010092-uftc8inx 842 15 phenotype phenotype NN cord-010092-uftc8inx 842 16 . . . cord-010092-uftc8inx 843 1 Results result NNS cord-010092-uftc8inx 843 2 : : : cord-010092-uftc8inx 844 1 Good good JJ cord-010092-uftc8inx 844 2 coverage coverage NN cord-010092-uftc8inx 844 3 of of IN cord-010092-uftc8inx 844 4 most most JJS cord-010092-uftc8inx 844 5 of of IN cord-010092-uftc8inx 844 6 the the DT cord-010092-uftc8inx 844 7 selected select VBN cord-010092-uftc8inx 844 8 genes gene NNS cord-010092-uftc8inx 844 9 was be VBD cord-010092-uftc8inx 844 10 achieved achieve VBN cord-010092-uftc8inx 844 11 . . . cord-010092-uftc8inx 845 1 Alignment alignment NN cord-010092-uftc8inx 845 2 of of IN cord-010092-uftc8inx 845 3 homologous homologous JJ cord-010092-uftc8inx 845 4 blood blood NN cord-010092-uftc8inx 845 5 group group NN cord-010092-uftc8inx 845 6 genes gene NNS cord-010092-uftc8inx 845 7 including include VBG cord-010092-uftc8inx 845 8 RHD RHD NNP cord-010092-uftc8inx 845 9 / / SYM cord-010092-uftc8inx 845 10 RHCE RHCE NNP cord-010092-uftc8inx 845 11 , , , cord-010092-uftc8inx 845 12 GYPA GYPA NNP cord-010092-uftc8inx 845 13 / / SYM cord-010092-uftc8inx 845 14 GYPB GYPB NNP cord-010092-uftc8inx 845 15 and and CC cord-010092-uftc8inx 845 16 C4A c4a NN cord-010092-uftc8inx 845 17 / / SYM cord-010092-uftc8inx 845 18 C4B c4b NN cord-010092-uftc8inx 845 19 was be VBD cord-010092-uftc8inx 845 20 problematic problematic JJ cord-010092-uftc8inx 845 21 and and CC cord-010092-uftc8inx 845 22 additional additional JJ cord-010092-uftc8inx 845 23 analysis analysis NN cord-010092-uftc8inx 845 24 of of IN cord-010092-uftc8inx 845 25 coverage coverage NN cord-010092-uftc8inx 845 26 of of IN cord-010092-uftc8inx 845 27 these these DT cord-010092-uftc8inx 845 28 genes gene NNS cord-010092-uftc8inx 845 29 was be VBD cord-010092-uftc8inx 845 30 required require VBN cord-010092-uftc8inx 845 31 for for IN cord-010092-uftc8inx 845 32 accurate accurate JJ cord-010092-uftc8inx 845 33 interpretation interpretation NN cord-010092-uftc8inx 845 34 . . . cord-010092-uftc8inx 846 1 Despite despite IN cord-010092-uftc8inx 846 2 a a DT cord-010092-uftc8inx 846 3 number number NN cord-010092-uftc8inx 846 4 of of IN cord-010092-uftc8inx 846 5 polymorphisms polymorphism NNS cord-010092-uftc8inx 846 6 observed observe VBN cord-010092-uftc8inx 846 7 across across IN cord-010092-uftc8inx 846 8 the the DT cord-010092-uftc8inx 846 9 tested test VBN cord-010092-uftc8inx 846 10 genes gene NNS cord-010092-uftc8inx 846 11 , , , cord-010092-uftc8inx 846 12 BEL BEL NNP cord-010092-uftc8inx 846 13 - - HYPH cord-010092-uftc8inx 846 14 A2 A2 NNP cord-010092-uftc8inx 846 15 did do VBD cord-010092-uftc8inx 846 16 not not RB cord-010092-uftc8inx 846 17 express express VB cord-010092-uftc8inx 846 18 any any DT cord-010092-uftc8inx 846 19 novel novel JJ cord-010092-uftc8inx 846 20 or or CC cord-010092-uftc8inx 846 21 rare rare JJ cord-010092-uftc8inx 846 22 blood blood NN cord-010092-uftc8inx 846 23 group group NN cord-010092-uftc8inx 846 24 antigens antigen NNS cord-010092-uftc8inx 846 25 . . . cord-010092-uftc8inx 847 1 Genotyping genotyping NN cord-010092-uftc8inx 847 2 results result NNS cord-010092-uftc8inx 847 3 predicted predict VBD cord-010092-uftc8inx 847 4 a a DT cord-010092-uftc8inx 847 5 common common JJ cord-010092-uftc8inx 847 6 antigenic antigenic JJ cord-010092-uftc8inx 847 7 profile profile NN cord-010092-uftc8inx 847 8 , , , cord-010092-uftc8inx 847 9 in in IN cord-010092-uftc8inx 847 10 agreement agreement NN cord-010092-uftc8inx 847 11 with with IN cord-010092-uftc8inx 847 12 previous previous JJ cord-010092-uftc8inx 847 13 serological serological JJ cord-010092-uftc8inx 847 14 and and CC cord-010092-uftc8inx 847 15 genotyping genotyping NN cord-010092-uftc8inx 847 16 results result NNS cord-010092-uftc8inx 847 17 where where WRB cord-010092-uftc8inx 847 18 available available JJ cord-010092-uftc8inx 847 19 . . . cord-010092-uftc8inx 848 1 Although although IN cord-010092-uftc8inx 848 2 a a DT cord-010092-uftc8inx 848 3 number number NN cord-010092-uftc8inx 848 4 of of IN cord-010092-uftc8inx 848 5 missense missense JJ cord-010092-uftc8inx 848 6 single single JJ cord-010092-uftc8inx 848 7 nucleotide nucleotide JJ cord-010092-uftc8inx 848 8 variations variation NNS cord-010092-uftc8inx 848 9 were be VBD cord-010092-uftc8inx 848 10 detected detect VBN cord-010092-uftc8inx 848 11 in in IN cord-010092-uftc8inx 848 12 analysed analyse VBN cord-010092-uftc8inx 848 13 genes gene NNS cord-010092-uftc8inx 848 14 , , , cord-010092-uftc8inx 848 15 including include VBG cord-010092-uftc8inx 848 16 CR1 CR1 NNP cord-010092-uftc8inx 848 17 , , , cord-010092-uftc8inx 848 18 CDAN1 cdan1 NN cord-010092-uftc8inx 848 19 and and CC cord-010092-uftc8inx 848 20 TMX4 TMX4 NNP cord-010092-uftc8inx 848 21 , , , cord-010092-uftc8inx 848 22 these these DT cord-010092-uftc8inx 848 23 were be VBD cord-010092-uftc8inx 848 24 common common JJ cord-010092-uftc8inx 848 25 polymorphic polymorphic JJ cord-010092-uftc8inx 848 26 variants variant NNS cord-010092-uftc8inx 848 27 and and CC cord-010092-uftc8inx 848 28 unlikely unlikely JJ cord-010092-uftc8inx 848 29 to to TO cord-010092-uftc8inx 848 30 be be VB cord-010092-uftc8inx 848 31 of of IN cord-010092-uftc8inx 848 32 any any DT cord-010092-uftc8inx 848 33 functional functional JJ cord-010092-uftc8inx 848 34 significance significance NN cord-010092-uftc8inx 848 35 . . . cord-010092-uftc8inx 849 1 Summary Summary NNP cord-010092-uftc8inx 849 2 / / SYM cord-010092-uftc8inx 849 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 849 4 : : : cord-010092-uftc8inx 850 1 WES WES NNP cord-010092-uftc8inx 850 2 was be VBD cord-010092-uftc8inx 850 3 used use VBN cord-010092-uftc8inx 850 4 to to TO cord-010092-uftc8inx 850 5 determine determine VB cord-010092-uftc8inx 850 6 BEL BEL NNP cord-010092-uftc8inx 850 7 - - HYPH cord-010092-uftc8inx 850 8 A2 A2 NNP cord-010092-uftc8inx 850 9 genotype genotype NN cord-010092-uftc8inx 850 10 in in IN cord-010092-uftc8inx 850 11 relation relation NN cord-010092-uftc8inx 850 12 to to IN cord-010092-uftc8inx 850 13 blood blood NN cord-010092-uftc8inx 850 14 group group NN cord-010092-uftc8inx 850 15 genes gene NNS cord-010092-uftc8inx 850 16 and and CC cord-010092-uftc8inx 850 17 selected select VBN cord-010092-uftc8inx 850 18 genes gene NNS cord-010092-uftc8inx 850 19 encoding encode VBG cord-010092-uftc8inx 850 20 transcription transcription NN cord-010092-uftc8inx 850 21 factors factor NNS cord-010092-uftc8inx 850 22 and and CC cord-010092-uftc8inx 850 23 proteins protein NNS cord-010092-uftc8inx 850 24 associated associate VBN cord-010092-uftc8inx 850 25 with with IN cord-010092-uftc8inx 850 26 cell cell NN cord-010092-uftc8inx 850 27 enucleation enucleation NN cord-010092-uftc8inx 850 28 . . . cord-010092-uftc8inx 851 1 WES WES NNP cord-010092-uftc8inx 851 2 allowed allow VBD cord-010092-uftc8inx 851 3 accurate accurate JJ cord-010092-uftc8inx 851 4 prediction prediction NN cord-010092-uftc8inx 851 5 of of IN cord-010092-uftc8inx 851 6 blood blood NN cord-010092-uftc8inx 851 7 group group NN cord-010092-uftc8inx 851 8 phenotypes phenotype NNS cord-010092-uftc8inx 851 9 , , , cord-010092-uftc8inx 851 10 showing show VBG cord-010092-uftc8inx 851 11 full full JJ cord-010092-uftc8inx 851 12 concordance concordance NN cord-010092-uftc8inx 851 13 with with IN cord-010092-uftc8inx 851 14 available available JJ cord-010092-uftc8inx 851 15 serological serological JJ cord-010092-uftc8inx 851 16 data datum NNS cord-010092-uftc8inx 852 1 ( ( -LRB- cord-010092-uftc8inx 852 2 Trakarnsanga Trakarnsanga NNP cord-010092-uftc8inx 852 3 et et FW cord-010092-uftc8inx 852 4 al al NNP cord-010092-uftc8inx 852 5 , , , cord-010092-uftc8inx 852 6 2017 2017 CD cord-010092-uftc8inx 852 7 ) ) -RRB- cord-010092-uftc8inx 852 8 . . . cord-010092-uftc8inx 853 1 A a DT cord-010092-uftc8inx 853 2 small small JJ cord-010092-uftc8inx 853 3 number number NN cord-010092-uftc8inx 853 4 of of IN cord-010092-uftc8inx 853 5 mutations mutation NNS cord-010092-uftc8inx 853 6 were be VBD cord-010092-uftc8inx 853 7 identified identify VBN cord-010092-uftc8inx 853 8 which which WDT cord-010092-uftc8inx 853 9 are be VBP cord-010092-uftc8inx 853 10 of of IN cord-010092-uftc8inx 853 11 unknown unknown JJ cord-010092-uftc8inx 853 12 significance significance NN cord-010092-uftc8inx 853 13 and and CC cord-010092-uftc8inx 853 14 require require VB cord-010092-uftc8inx 853 15 further further JJ cord-010092-uftc8inx 853 16 work work NN cord-010092-uftc8inx 853 17 to to TO cord-010092-uftc8inx 853 18 determine determine VB cord-010092-uftc8inx 853 19 any any DT cord-010092-uftc8inx 853 20 potential potential JJ cord-010092-uftc8inx 853 21 phenotypic phenotypic JJ cord-010092-uftc8inx 853 22 effects effect NNS cord-010092-uftc8inx 853 23 . . . cord-010092-uftc8inx 854 1 This this DT cord-010092-uftc8inx 854 2 complete complete JJ cord-010092-uftc8inx 854 3 record record NN cord-010092-uftc8inx 854 4 of of IN cord-010092-uftc8inx 854 5 the the DT cord-010092-uftc8inx 854 6 BEL BEL NNP cord-010092-uftc8inx 854 7 - - HYPH cord-010092-uftc8inx 854 8 A2 A2 NNP cord-010092-uftc8inx 854 9 blood blood NN cord-010092-uftc8inx 854 10 group group NN cord-010092-uftc8inx 854 11 - - HYPH cord-010092-uftc8inx 854 12 related relate VBN cord-010092-uftc8inx 854 13 exome exome NN cord-010092-uftc8inx 854 14 will will MD cord-010092-uftc8inx 854 15 enable enable VB cord-010092-uftc8inx 854 16 reliable reliable JJ cord-010092-uftc8inx 854 17 gene gene NN cord-010092-uftc8inx 854 18 editing edit VBG cord-010092-uftc8inx 854 19 strategies strategy NNS cord-010092-uftc8inx 854 20 for for IN cord-010092-uftc8inx 854 21 future future JJ cord-010092-uftc8inx 854 22 diagnostic diagnostic JJ cord-010092-uftc8inx 854 23 and and CC cord-010092-uftc8inx 854 24 therapeutic therapeutic JJ cord-010092-uftc8inx 854 25 purposes purpose NNS cord-010092-uftc8inx 854 26 . . . cord-010092-uftc8inx 855 1 Additionally additionally RB cord-010092-uftc8inx 855 2 , , , cord-010092-uftc8inx 855 3 knowledge knowledge NN cord-010092-uftc8inx 855 4 of of IN cord-010092-uftc8inx 855 5 the the DT cord-010092-uftc8inx 855 6 full full JJ cord-010092-uftc8inx 855 7 cell cell NN cord-010092-uftc8inx 855 8 line line NN cord-010092-uftc8inx 855 9 exome exome NN cord-010092-uftc8inx 855 10 will will MD cord-010092-uftc8inx 855 11 allow allow VB cord-010092-uftc8inx 855 12 analysis analysis NN cord-010092-uftc8inx 855 13 of of IN cord-010092-uftc8inx 855 14 any any DT cord-010092-uftc8inx 855 15 emerging emerge VBG cord-010092-uftc8inx 855 16 genes gene NNS cord-010092-uftc8inx 855 17 of of IN cord-010092-uftc8inx 855 18 interest interest NN cord-010092-uftc8inx 855 19 and and CC cord-010092-uftc8inx 855 20 provide provide VB cord-010092-uftc8inx 855 21 better well JJR cord-010092-uftc8inx 855 22 insight insight NN cord-010092-uftc8inx 855 23 into into IN cord-010092-uftc8inx 855 24 the the DT cord-010092-uftc8inx 855 25 mechanisms mechanism NNS cord-010092-uftc8inx 855 26 of of IN cord-010092-uftc8inx 855 27 erythroid erythroid JJ cord-010092-uftc8inx 855 28 differentiation differentiation NN cord-010092-uftc8inx 855 29 and and CC cord-010092-uftc8inx 855 30 enucleation enucleation NN cord-010092-uftc8inx 855 31 . . . cord-010092-uftc8inx 856 1 Background background NN cord-010092-uftc8inx 856 2 : : : cord-010092-uftc8inx 857 1 Emerging emerge VBG cord-010092-uftc8inx 857 2 evidence evidence NN cord-010092-uftc8inx 857 3 , , , cord-010092-uftc8inx 857 4 especially especially RB cord-010092-uftc8inx 857 5 in in IN cord-010092-uftc8inx 857 6 neonates neonate NNS cord-010092-uftc8inx 857 7 , , , cord-010092-uftc8inx 857 8 has have VBZ cord-010092-uftc8inx 857 9 shown show VBN cord-010092-uftc8inx 857 10 potential potential JJ cord-010092-uftc8inx 857 11 harm harm NN cord-010092-uftc8inx 857 12 associated associate VBN cord-010092-uftc8inx 857 13 with with IN cord-010092-uftc8inx 857 14 liberal liberal JJ cord-010092-uftc8inx 857 15 platelet platelet NN cord-010092-uftc8inx 857 16 transfusion transfusion NN cord-010092-uftc8inx 857 17 strategies strategy NNS cord-010092-uftc8inx 857 18 . . . cord-010092-uftc8inx 858 1 Very very RB cord-010092-uftc8inx 858 2 little little JJ cord-010092-uftc8inx 858 3 evidence evidence NN cord-010092-uftc8inx 858 4 exists exist VBZ cord-010092-uftc8inx 858 5 regarding regard VBG cord-010092-uftc8inx 858 6 optimal optimal JJ cord-010092-uftc8inx 858 7 platelet platelet NN cord-010092-uftc8inx 858 8 transfusion transfusion NN cord-010092-uftc8inx 858 9 thresholds threshold NNS cord-010092-uftc8inx 858 10 in in IN cord-010092-uftc8inx 858 11 critically critically RB cord-010092-uftc8inx 858 12 ill ill JJ cord-010092-uftc8inx 858 13 children child NNS cord-010092-uftc8inx 858 14 . . . cord-010092-uftc8inx 859 1 Randomized randomized JJ cord-010092-uftc8inx 859 2 controlled control VBN cord-010092-uftc8inx 859 3 trials trial NNS cord-010092-uftc8inx 859 4 may may MD cord-010092-uftc8inx 859 5 be be VB cord-010092-uftc8inx 859 6 difficult difficult JJ cord-010092-uftc8inx 859 7 due due IN cord-010092-uftc8inx 859 8 to to IN cord-010092-uftc8inx 859 9 lack lack NN cord-010092-uftc8inx 859 10 of of IN cord-010092-uftc8inx 859 11 equipoise equipoise NN cord-010092-uftc8inx 859 12 from from IN cord-010092-uftc8inx 859 13 providers provider NNS cord-010092-uftc8inx 859 14 . . . cord-010092-uftc8inx 860 1 If if IN cord-010092-uftc8inx 860 2 regional regional JJ cord-010092-uftc8inx 860 3 variation variation NN cord-010092-uftc8inx 860 4 in in IN cord-010092-uftc8inx 860 5 practice practice NN cord-010092-uftc8inx 860 6 exists exist VBZ cord-010092-uftc8inx 860 7 , , , cord-010092-uftc8inx 860 8 comparative comparative JJ cord-010092-uftc8inx 860 9 effectiveness effectiveness NN cord-010092-uftc8inx 860 10 studies study NNS cord-010092-uftc8inx 860 11 may may MD cord-010092-uftc8inx 860 12 be be VB cord-010092-uftc8inx 860 13 an an DT cord-010092-uftc8inx 860 14 alternative alternative JJ cord-010092-uftc8inx 860 15 approach approach NN cord-010092-uftc8inx 860 16 . . . cord-010092-uftc8inx 861 1 Aims aim VBZ cord-010092-uftc8inx 861 2 : : : cord-010092-uftc8inx 861 3 To to TO cord-010092-uftc8inx 861 4 describe describe VB cord-010092-uftc8inx 861 5 regional regional JJ cord-010092-uftc8inx 861 6 variation variation NN cord-010092-uftc8inx 861 7 in in IN cord-010092-uftc8inx 861 8 platelet platelet NN cord-010092-uftc8inx 861 9 transfusion transfusion NN cord-010092-uftc8inx 861 10 practices practice NNS cord-010092-uftc8inx 861 11 in in IN cord-010092-uftc8inx 861 12 critically critically RB cord-010092-uftc8inx 861 13 ill ill JJ cord-010092-uftc8inx 861 14 children child NNS cord-010092-uftc8inx 861 15 . . . cord-010092-uftc8inx 862 1 Methods method NNS cord-010092-uftc8inx 862 2 : : : cord-010092-uftc8inx 862 3 Secondary secondary JJ cord-010092-uftc8inx 862 4 analysis analysis NN cord-010092-uftc8inx 862 5 of of IN cord-010092-uftc8inx 862 6 a a DT cord-010092-uftc8inx 862 7 prospective prospective JJ cord-010092-uftc8inx 862 8 , , , cord-010092-uftc8inx 862 9 observational observational JJ cord-010092-uftc8inx 862 10 study study NN cord-010092-uftc8inx 862 11 . . . cord-010092-uftc8inx 863 1 Subjects subject NNS cord-010092-uftc8inx 863 2 were be VBD cord-010092-uftc8inx 863 3 grouped group VBN cord-010092-uftc8inx 863 4 according accord VBG cord-010092-uftc8inx 863 5 to to IN cord-010092-uftc8inx 863 6 region region NN cord-010092-uftc8inx 863 7 ( ( -LRB- cord-010092-uftc8inx 863 8 North North NNP cord-010092-uftc8inx 863 9 America America NNP cord-010092-uftc8inx 863 10 , , , cord-010092-uftc8inx 863 11 Europe Europe NNP cord-010092-uftc8inx 863 12 , , , cord-010092-uftc8inx 863 13 Middle Middle NNP cord-010092-uftc8inx 863 14 East East NNP cord-010092-uftc8inx 863 15 , , , cord-010092-uftc8inx 863 16 Asia Asia NNP cord-010092-uftc8inx 863 17 and and CC cord-010092-uftc8inx 863 18 Oceania Oceania NNP cord-010092-uftc8inx 863 19 ) ) -RRB- cord-010092-uftc8inx 863 20 and and CC cord-010092-uftc8inx 863 21 nation nation NN cord-010092-uftc8inx 863 22 . . . cord-010092-uftc8inx 864 1 Transfusions transfusion NNS cord-010092-uftc8inx 864 2 were be VBD cord-010092-uftc8inx 864 3 analyzed analyze VBN cord-010092-uftc8inx 864 4 as as IN cord-010092-uftc8inx 864 5 prophylactic prophylactic JJ cord-010092-uftc8inx 864 6 ( ( -LRB- cord-010092-uftc8inx 864 7 given give VBN cord-010092-uftc8inx 864 8 to to TO cord-010092-uftc8inx 864 9 prevent prevent VB cord-010092-uftc8inx 864 10 bleeding bleeding NN cord-010092-uftc8inx 864 11 ) ) -RRB- cord-010092-uftc8inx 864 12 or or CC cord-010092-uftc8inx 864 13 therapeutic therapeutic JJ cord-010092-uftc8inx 864 14 ( ( -LRB- cord-010092-uftc8inx 864 15 given give VBN cord-010092-uftc8inx 864 16 to to TO cord-010092-uftc8inx 864 17 treat treat VB cord-010092-uftc8inx 864 18 bleeding bleed VBG cord-010092-uftc8inx 864 19 ) ) -RRB- cord-010092-uftc8inx 864 20 . . . cord-010092-uftc8inx 865 1 The the DT cord-010092-uftc8inx 865 2 primary primary JJ cord-010092-uftc8inx 865 3 outcome outcome NN cord-010092-uftc8inx 865 4 was be VBD cord-010092-uftc8inx 865 5 the the DT cord-010092-uftc8inx 865 6 total total JJ cord-010092-uftc8inx 865 7 platelet platelet NN cord-010092-uftc8inx 865 8 count count NN cord-010092-uftc8inx 865 9 ( ( -LRB- cord-010092-uftc8inx 865 10 TPC TPC NNP cord-010092-uftc8inx 865 11 ) ) -RRB- cord-010092-uftc8inx 865 12 prior prior RB cord-010092-uftc8inx 865 13 to to IN cord-010092-uftc8inx 865 14 transfusion transfusion NN cord-010092-uftc8inx 865 15 . . . cord-010092-uftc8inx 866 1 Sub sub NN cord-010092-uftc8inx 866 2 - - HYPH cord-010092-uftc8inx 866 3 groups group NNS cord-010092-uftc8inx 866 4 analyses analysis NNS cord-010092-uftc8inx 866 5 were be VBD cord-010092-uftc8inx 866 6 performed perform VBN cord-010092-uftc8inx 866 7 in in IN cord-010092-uftc8inx 866 8 children child NNS cord-010092-uftc8inx 866 9 with with IN cord-010092-uftc8inx 866 10 an an DT cord-010092-uftc8inx 866 11 underlying underlying JJ cord-010092-uftc8inx 866 12 oncologic oncologic JJ cord-010092-uftc8inx 866 13 diagnosis diagnosis NN cord-010092-uftc8inx 866 14 and and CC cord-010092-uftc8inx 866 15 those those DT cord-010092-uftc8inx 866 16 supported support VBN cord-010092-uftc8inx 866 17 by by IN cord-010092-uftc8inx 866 18 extracorporeal extracorporeal JJ cord-010092-uftc8inx 866 19 life life NN cord-010092-uftc8inx 866 20 support support NN cord-010092-uftc8inx 866 21 ( ( -LRB- cord-010092-uftc8inx 866 22 ECLS ECLS NNP cord-010092-uftc8inx 866 23 ) ) -RRB- cord-010092-uftc8inx 866 24 . . . cord-010092-uftc8inx 867 1 The the DT cord-010092-uftc8inx 867 2 dosing dosing NN cord-010092-uftc8inx 867 3 and and CC cord-010092-uftc8inx 867 4 processing processing NN cord-010092-uftc8inx 867 5 of of IN cord-010092-uftc8inx 867 6 the the DT cord-010092-uftc8inx 867 7 platelet platelet NN cord-010092-uftc8inx 867 8 transfusions transfusion NNS cord-010092-uftc8inx 867 9 were be VBD cord-010092-uftc8inx 867 10 analyzed analyze VBN cord-010092-uftc8inx 867 11 as as IN cord-010092-uftc8inx 867 12 secondary secondary JJ cord-010092-uftc8inx 867 13 outcomes outcome NNS cord-010092-uftc8inx 867 14 . . . cord-010092-uftc8inx 868 1 Results result NNS cord-010092-uftc8inx 868 2 : : : cord-010092-uftc8inx 869 1 Five five CD cord-010092-uftc8inx 869 2 hundred hundred CD cord-010092-uftc8inx 869 3 and and CC cord-010092-uftc8inx 869 4 forty forty CD cord-010092-uftc8inx 869 5 - - HYPH cord-010092-uftc8inx 869 6 nine nine CD cord-010092-uftc8inx 869 7 children child NNS cord-010092-uftc8inx 869 8 from from IN cord-010092-uftc8inx 869 9 16 16 CD cord-010092-uftc8inx 869 10 countries country NNS cord-010092-uftc8inx 869 11 were be VBD cord-010092-uftc8inx 869 12 enrolled enrol VBN cord-010092-uftc8inx 869 13 ( ( -LRB- cord-010092-uftc8inx 869 14 67 67 CD cord-010092-uftc8inx 869 15 % % NN cord-010092-uftc8inx 869 16 in in IN cord-010092-uftc8inx 869 17 North North NNP cord-010092-uftc8inx 869 18 America America NNP cord-010092-uftc8inx 869 19 , , , cord-010092-uftc8inx 869 20 17 17 CD cord-010092-uftc8inx 869 21 % % NN cord-010092-uftc8inx 869 22 in in IN cord-010092-uftc8inx 869 23 Europe Europe NNP cord-010092-uftc8inx 869 24 , , , cord-010092-uftc8inx 869 25 7 7 CD cord-010092-uftc8inx 869 26 % % NN cord-010092-uftc8inx 869 27 in in IN cord-010092-uftc8inx 869 28 Oceania Oceania NNP cord-010092-uftc8inx 869 29 , , , cord-010092-uftc8inx 869 30 5 5 CD cord-010092-uftc8inx 869 31 % % NN cord-010092-uftc8inx 869 32 in in IN cord-010092-uftc8inx 869 33 Asia Asia NNP cord-010092-uftc8inx 869 34 , , , cord-010092-uftc8inx 869 35 and and CC cord-010092-uftc8inx 869 36 4 4 CD cord-010092-uftc8inx 869 37 % % NN cord-010092-uftc8inx 869 38 in in IN cord-010092-uftc8inx 869 39 the the DT cord-010092-uftc8inx 869 40 Middle Middle NNP cord-010092-uftc8inx 869 41 East East NNP cord-010092-uftc8inx 869 42 ) ) -RRB- cord-010092-uftc8inx 869 43 . . . cord-010092-uftc8inx 870 1 Overall overall RB cord-010092-uftc8inx 870 2 , , , cord-010092-uftc8inx 870 3 the the DT cord-010092-uftc8inx 870 4 median median NN cord-010092-uftc8inx 870 5 ( ( -LRB- cord-010092-uftc8inx 870 6 IQR IQR NNP cord-010092-uftc8inx 870 7 ) ) -RRB- cord-010092-uftc8inx 870 8 TPC TPC NNP cord-010092-uftc8inx 870 9 prior prior RB cord-010092-uftc8inx 870 10 to to IN cord-010092-uftc8inx 870 11 prophylactic prophylactic JJ cord-010092-uftc8inx 870 12 transfusions transfusion NNS cord-010092-uftc8inx 870 13 ( ( -LRB- cord-010092-uftc8inx 870 14 n n NN cord-010092-uftc8inx 870 15 = = SYM cord-010092-uftc8inx 870 16 360 360 CD cord-010092-uftc8inx 870 17 ) ) -RRB- cord-010092-uftc8inx 870 18 differed differ VBD cord-010092-uftc8inx 870 19 significantly significantly RB cord-010092-uftc8inx 870 20 on on IN cord-010092-uftc8inx 870 21 a a DT cord-010092-uftc8inx 870 22 regional regional JJ cord-010092-uftc8inx 870 23 basis basis NN cord-010092-uftc8inx 870 24 ( ( -LRB- cord-010092-uftc8inx 870 25 P p NN cord-010092-uftc8inx 870 26 = = SYM cord-010092-uftc8inx 870 27 0.04 0.04 CD cord-010092-uftc8inx 870 28 ) ) -RRB- cord-010092-uftc8inx 870 29 and and CC cord-010092-uftc8inx 870 30 ranged range VBD cord-010092-uftc8inx 870 31 from from IN cord-010092-uftc8inx 870 32 12 12 CD cord-010092-uftc8inx 870 33 ( ( -LRB- cord-010092-uftc8inx 870 34 8 8 CD cord-010092-uftc8inx 870 35 - - SYM cord-010092-uftc8inx 870 36 41 41 CD cord-010092-uftc8inx 870 37 ) ) -RRB- cord-010092-uftc8inx 870 38 x10 x10 CD cord-010092-uftc8inx 870 39 9 9 CD cord-010092-uftc8inx 870 40 cells cell NNS cord-010092-uftc8inx 870 41 / / SYM cord-010092-uftc8inx 870 42 L l NN cord-010092-uftc8inx 870 43 in in IN cord-010092-uftc8inx 870 44 the the DT cord-010092-uftc8inx 870 45 Middle Middle NNP cord-010092-uftc8inx 870 46 East East NNP cord-010092-uftc8inx 870 47 to to IN cord-010092-uftc8inx 870 48 45 45 CD cord-010092-uftc8inx 870 49 ( ( -LRB- cord-010092-uftc8inx 870 50 20 20 CD cord-010092-uftc8inx 870 51 - - SYM cord-010092-uftc8inx 870 52 66 66 CD cord-010092-uftc8inx 870 53 ) ) -RRB- cord-010092-uftc8inx 870 54 x10 x10 CD cord-010092-uftc8inx 870 55 9 9 CD cord-010092-uftc8inx 870 56 cells cell NNS cord-010092-uftc8inx 870 57 / / SYM cord-010092-uftc8inx 870 58 L l NN cord-010092-uftc8inx 870 59 in in IN cord-010092-uftc8inx 870 60 Asia Asia NNP cord-010092-uftc8inx 870 61 . . . cord-010092-uftc8inx 871 1 The the DT cord-010092-uftc8inx 871 2 median median JJ cord-010092-uftc8inx 871 3 TPC tpc NN cord-010092-uftc8inx 871 4 prior prior RB cord-010092-uftc8inx 871 5 to to IN cord-010092-uftc8inx 871 6 prophylactic prophylactic JJ cord-010092-uftc8inx 871 7 transfusions transfusion NNS cord-010092-uftc8inx 871 8 did do VBD cord-010092-uftc8inx 871 9 not not RB cord-010092-uftc8inx 871 10 significantly significantly RB cord-010092-uftc8inx 871 11 differ differ VB cord-010092-uftc8inx 871 12 between between IN cord-010092-uftc8inx 871 13 countries country NNS cord-010092-uftc8inx 871 14 ( ( -LRB- cord-010092-uftc8inx 871 15 P p NN cord-010092-uftc8inx 871 16 = = SYM cord-010092-uftc8inx 871 17 0.08 0.08 CD cord-010092-uftc8inx 871 18 ) ) -RRB- cord-010092-uftc8inx 871 19 , , , cord-010092-uftc8inx 871 20 nor nor CC cord-010092-uftc8inx 871 21 did do VBD cord-010092-uftc8inx 871 22 the the DT cord-010092-uftc8inx 871 23 TPC TPC NNP cord-010092-uftc8inx 871 24 prior prior RB cord-010092-uftc8inx 871 25 to to IN cord-010092-uftc8inx 871 26 therapeutic therapeutic JJ cord-010092-uftc8inx 871 27 transfusions transfusion NNS cord-010092-uftc8inx 871 28 ( ( -LRB- cord-010092-uftc8inx 871 29 n n NN cord-010092-uftc8inx 871 30 = = SYM cord-010092-uftc8inx 871 31 189 189 CD cord-010092-uftc8inx 871 32 ) ) -RRB- cord-010092-uftc8inx 871 33 differ differ VBP cord-010092-uftc8inx 871 34 on on IN cord-010092-uftc8inx 871 35 either either CC cord-010092-uftc8inx 871 36 a a DT cord-010092-uftc8inx 871 37 regional regional JJ cord-010092-uftc8inx 871 38 ( ( -LRB- cord-010092-uftc8inx 871 39 P p NN cord-010092-uftc8inx 871 40 = = SYM cord-010092-uftc8inx 871 41 0.16 0.16 CD cord-010092-uftc8inx 871 42 ) ) -RRB- cord-010092-uftc8inx 871 43 or or CC cord-010092-uftc8inx 871 44 national national JJ cord-010092-uftc8inx 871 45 ( ( -LRB- cord-010092-uftc8inx 871 46 P p NN cord-010092-uftc8inx 871 47 = = SYM cord-010092-uftc8inx 871 48 0.57 0.57 CD cord-010092-uftc8inx 871 49 ) ) -RRB- cord-010092-uftc8inx 871 50 basis basis NN cord-010092-uftc8inx 871 51 . . . cord-010092-uftc8inx 872 1 For for IN cord-010092-uftc8inx 872 2 children child NNS cord-010092-uftc8inx 872 3 supported support VBN cord-010092-uftc8inx 872 4 by by IN cord-010092-uftc8inx 872 5 ECLS ECLS NNP cord-010092-uftc8inx 872 6 ( ( -LRB- cord-010092-uftc8inx 872 7 n n NN cord-010092-uftc8inx 872 8 = = SYM cord-010092-uftc8inx 872 9 90 90 CD cord-010092-uftc8inx 872 10 ) ) -RRB- cord-010092-uftc8inx 872 11 , , , cord-010092-uftc8inx 872 12 there there EX cord-010092-uftc8inx 872 13 were be VBD cord-010092-uftc8inx 872 14 no no DT cord-010092-uftc8inx 872 15 regional regional JJ cord-010092-uftc8inx 872 16 ( ( -LRB- cord-010092-uftc8inx 872 17 P p NN cord-010092-uftc8inx 872 18 = = SYM cord-010092-uftc8inx 872 19 0.06 0.06 CD cord-010092-uftc8inx 872 20 ) ) -RRB- cord-010092-uftc8inx 872 21 or or CC cord-010092-uftc8inx 872 22 national national JJ cord-010092-uftc8inx 872 23 ( ( -LRB- cord-010092-uftc8inx 872 24 P p NN cord-010092-uftc8inx 872 25 = = SYM cord-010092-uftc8inx 872 26 0.40 0.40 CD cord-010092-uftc8inx 872 27 ) ) -RRB- cord-010092-uftc8inx 872 28 differences difference NNS cord-010092-uftc8inx 872 29 for for IN cord-010092-uftc8inx 872 30 prophylactic prophylactic JJ cord-010092-uftc8inx 872 31 transfusions transfusion NNS cord-010092-uftc8inx 872 32 . . . cord-010092-uftc8inx 873 1 However however RB cord-010092-uftc8inx 873 2 , , , cord-010092-uftc8inx 873 3 significant significant JJ cord-010092-uftc8inx 873 4 differences difference NNS cord-010092-uftc8inx 873 5 in in IN cord-010092-uftc8inx 873 6 the the DT cord-010092-uftc8inx 873 7 TPC TPC NNP cord-010092-uftc8inx 873 8 prior prior RB cord-010092-uftc8inx 873 9 to to IN cord-010092-uftc8inx 873 10 therapeutic therapeutic JJ cord-010092-uftc8inx 873 11 transfusions transfusion NNS cord-010092-uftc8inx 873 12 were be VBD cord-010092-uftc8inx 873 13 observed observe VBN cord-010092-uftc8inx 873 14 on on IN cord-010092-uftc8inx 873 15 both both CC cord-010092-uftc8inx 873 16 a a DT cord-010092-uftc8inx 873 17 regional regional JJ cord-010092-uftc8inx 873 18 ( ( -LRB- cord-010092-uftc8inx 873 19 P p NN cord-010092-uftc8inx 873 20 = = SYM cord-010092-uftc8inx 873 21 0.02 0.02 CD cord-010092-uftc8inx 873 22 ) ) -RRB- cord-010092-uftc8inx 873 23 and and CC cord-010092-uftc8inx 873 24 national national JJ cord-010092-uftc8inx 873 25 ( ( -LRB- cord-010092-uftc8inx 873 26 0.04 0.04 CD cord-010092-uftc8inx 873 27 ) ) -RRB- cord-010092-uftc8inx 873 28 basis basis NN cord-010092-uftc8inx 873 29 with with IN cord-010092-uftc8inx 873 30 the the DT cord-010092-uftc8inx 873 31 Middle Middle NNP cord-010092-uftc8inx 873 32 East East NNP cord-010092-uftc8inx 873 33 , , , cord-010092-uftc8inx 873 34 in in IN cord-010092-uftc8inx 873 35 particular particular JJ cord-010092-uftc8inx 873 36 Israel Israel NNP cord-010092-uftc8inx 873 37 , , , cord-010092-uftc8inx 873 38 transfusing transfuse VBG cord-010092-uftc8inx 873 39 at at IN cord-010092-uftc8inx 873 40 the the DT cord-010092-uftc8inx 873 41 lowest low JJS cord-010092-uftc8inx 873 42 median median NN cord-010092-uftc8inx 873 43 ( ( -LRB- cord-010092-uftc8inx 873 44 IQR IQR NNP cord-010092-uftc8inx 873 45 ) ) -RRB- cord-010092-uftc8inx 873 46 TPC TPC NNP cord-010092-uftc8inx 873 47 [ [ -LRB- cord-010092-uftc8inx 873 48 28 28 CD cord-010092-uftc8inx 873 49 ( ( -LRB- cord-010092-uftc8inx 873 50 16 16 CD cord-010092-uftc8inx 873 51 - - SYM cord-010092-uftc8inx 873 52 81 81 CD cord-010092-uftc8inx 873 53 ) ) -RRB- cord-010092-uftc8inx 873 54 x10 x10 CD cord-010092-uftc8inx 873 55 9 9 CD cord-010092-uftc8inx 873 56 cells cell NNS cord-010092-uftc8inx 873 57 / / SYM cord-010092-uftc8inx 873 58 L l NN cord-010092-uftc8inx 873 59 ] ] -RRB- cord-010092-uftc8inx 873 60 . . . cord-010092-uftc8inx 874 1 For for IN cord-010092-uftc8inx 874 2 children child NNS cord-010092-uftc8inx 874 3 with with IN cord-010092-uftc8inx 874 4 an an DT cord-010092-uftc8inx 874 5 underlying underlying JJ cord-010092-uftc8inx 874 6 oncologic oncologic JJ cord-010092-uftc8inx 874 7 diagnosis diagnosis NN cord-010092-uftc8inx 874 8 ( ( -LRB- cord-010092-uftc8inx 874 9 n n NN cord-010092-uftc8inx 874 10 = = SYM cord-010092-uftc8inx 874 11 233 233 CD cord-010092-uftc8inx 874 12 ) ) -RRB- cord-010092-uftc8inx 874 13 , , , cord-010092-uftc8inx 874 14 no no DT cord-010092-uftc8inx 874 15 differences difference NNS cord-010092-uftc8inx 874 16 were be VBD cord-010092-uftc8inx 874 17 seen see VBN cord-010092-uftc8inx 874 18 in in IN cord-010092-uftc8inx 874 19 the the DT cord-010092-uftc8inx 874 20 TPC TPC NNP cord-010092-uftc8inx 874 21 for for IN cord-010092-uftc8inx 874 22 prophylactic prophylactic JJ cord-010092-uftc8inx 874 23 transfusions transfusion NNS cord-010092-uftc8inx 874 24 ( ( -LRB- cord-010092-uftc8inx 874 25 n n NN cord-010092-uftc8inx 874 26 = = SYM cord-010092-uftc8inx 874 27 175 175 CD cord-010092-uftc8inx 874 28 ) ) -RRB- cord-010092-uftc8inx 874 29 on on IN cord-010092-uftc8inx 874 30 a a DT cord-010092-uftc8inx 874 31 regional regional JJ cord-010092-uftc8inx 874 32 ( ( -LRB- cord-010092-uftc8inx 874 33 P p NN cord-010092-uftc8inx 874 34 = = SYM cord-010092-uftc8inx 874 35 0.19 0.19 CD cord-010092-uftc8inx 874 36 ) ) -RRB- cord-010092-uftc8inx 874 37 or or CC cord-010092-uftc8inx 874 38 national national JJ cord-010092-uftc8inx 874 39 ( ( -LRB- cord-010092-uftc8inx 874 40 P p NN cord-010092-uftc8inx 874 41 = = SYM cord-010092-uftc8inx 874 42 0.20 0.20 CD cord-010092-uftc8inx 874 43 ) ) -RRB- cord-010092-uftc8inx 874 44 basis basis NN cord-010092-uftc8inx 874 45 . . . cord-010092-uftc8inx 875 1 Nor nor CC cord-010092-uftc8inx 875 2 were be VBD cord-010092-uftc8inx 875 3 differences difference NNS cord-010092-uftc8inx 875 4 seen see VBN cord-010092-uftc8inx 875 5 in in IN cord-010092-uftc8inx 875 6 the the DT cord-010092-uftc8inx 875 7 TPC TPC NNP cord-010092-uftc8inx 875 8 prior prior RB cord-010092-uftc8inx 875 9 to to IN cord-010092-uftc8inx 875 10 therapeutic therapeutic JJ cord-010092-uftc8inx 875 11 transfusions transfusion NNS cord-010092-uftc8inx 875 12 on on IN cord-010092-uftc8inx 875 13 a a DT cord-010092-uftc8inx 875 14 regional regional JJ cord-010092-uftc8inx 875 15 ( ( -LRB- cord-010092-uftc8inx 875 16 0.86 0.86 CD cord-010092-uftc8inx 875 17 ) ) -RRB- cord-010092-uftc8inx 875 18 or or CC cord-010092-uftc8inx 875 19 national national JJ cord-010092-uftc8inx 875 20 ( ( -LRB- cord-010092-uftc8inx 875 21 P p NN cord-010092-uftc8inx 875 22 = = SYM cord-010092-uftc8inx 875 23 0.33 0.33 CD cord-010092-uftc8inx 875 24 ) ) -RRB- cord-010092-uftc8inx 875 25 basis basis NN cord-010092-uftc8inx 875 26 . . . cord-010092-uftc8inx 876 1 There there EX cord-010092-uftc8inx 876 2 was be VBD cord-010092-uftc8inx 876 3 significant significant JJ cord-010092-uftc8inx 876 4 variability variability NN cord-010092-uftc8inx 876 5 in in IN cord-010092-uftc8inx 876 6 the the DT cord-010092-uftc8inx 876 7 dosing dosing NN cord-010092-uftc8inx 876 8 of of IN cord-010092-uftc8inx 876 9 platelet platelet NN cord-010092-uftc8inx 876 10 transfusions transfusion NNS cord-010092-uftc8inx 876 11 on on IN cord-010092-uftc8inx 876 12 both both CC cord-010092-uftc8inx 876 13 a a DT cord-010092-uftc8inx 876 14 regional regional JJ cord-010092-uftc8inx 876 15 ( ( -LRB- cord-010092-uftc8inx 876 16 P p NN cord-010092-uftc8inx 876 17 < < XX cord-010092-uftc8inx 876 18 0.001 0.001 CD cord-010092-uftc8inx 876 19 ) ) -RRB- cord-010092-uftc8inx 876 20 and and CC cord-010092-uftc8inx 876 21 national national JJ cord-010092-uftc8inx 876 22 basis basis NN cord-010092-uftc8inx 876 23 ( ( -LRB- cord-010092-uftc8inx 876 24 P p NN cord-010092-uftc8inx 876 25 < < XX cord-010092-uftc8inx 876 26 0.001 0.001 CD cord-010092-uftc8inx 876 27 ) ) -RRB- cord-010092-uftc8inx 876 28 . . . cord-010092-uftc8inx 877 1 The the DT cord-010092-uftc8inx 877 2 median median NN cord-010092-uftc8inx 877 3 ( ( -LRB- cord-010092-uftc8inx 877 4 IQR IQR NNP cord-010092-uftc8inx 877 5 ) ) -RRB- cord-010092-uftc8inx 877 6 dose dose NN cord-010092-uftc8inx 877 7 based base VBN cord-010092-uftc8inx 877 8 on on IN cord-010092-uftc8inx 877 9 volume volume NN cord-010092-uftc8inx 877 10 ranged range VBN cord-010092-uftc8inx 877 11 from from IN cord-010092-uftc8inx 877 12 8.4 8.4 CD cord-010092-uftc8inx 877 13 ( ( -LRB- cord-010092-uftc8inx 877 14 5.0 5.0 CD cord-010092-uftc8inx 877 15 - - SYM cord-010092-uftc8inx 877 16 11.2 11.2 CD cord-010092-uftc8inx 877 17 ) ) -RRB- cord-010092-uftc8inx 877 18 ml ml NN cord-010092-uftc8inx 877 19 / / SYM cord-010092-uftc8inx 877 20 kg kg NN cord-010092-uftc8inx 877 21 in in IN cord-010092-uftc8inx 877 22 North North NNP cord-010092-uftc8inx 877 23 America America NNP cord-010092-uftc8inx 877 24 to to IN cord-010092-uftc8inx 877 25 12.6 12.6 CD cord-010092-uftc8inx 877 26 ( ( -LRB- cord-010092-uftc8inx 877 27 9.8 9.8 CD cord-010092-uftc8inx 877 28 - - HYPH cord-010092-uftc8inx 877 29 16.0 16.0 CD cord-010092-uftc8inx 877 30 ) ) -RRB- cord-010092-uftc8inx 877 31 ml ml NN cord-010092-uftc8inx 877 32 / / SYM cord-010092-uftc8inx 877 33 kg kg NN cord-010092-uftc8inx 877 34 in in IN cord-010092-uftc8inx 877 35 Europe Europe NNP cord-010092-uftc8inx 877 36 . . . cord-010092-uftc8inx 878 1 The the DT cord-010092-uftc8inx 878 2 vast vast JJ cord-010092-uftc8inx 878 3 majority majority NN cord-010092-uftc8inx 878 4 of of IN cord-010092-uftc8inx 878 5 transfusions transfusion NNS cord-010092-uftc8inx 878 6 were be VBD cord-010092-uftc8inx 878 7 leukoreduced leukoreduce VBN cord-010092-uftc8inx 878 8 and and CC cord-010092-uftc8inx 878 9 irradiated irradiate VBN cord-010092-uftc8inx 878 10 but but CC cord-010092-uftc8inx 878 11 significant significant JJ cord-010092-uftc8inx 878 12 variation variation NN cord-010092-uftc8inx 878 13 exists exist VBZ cord-010092-uftc8inx 878 14 in in IN cord-010092-uftc8inx 878 15 storage storage NN cord-010092-uftc8inx 878 16 duration duration NN cord-010092-uftc8inx 878 17 on on IN cord-010092-uftc8inx 878 18 both both CC cord-010092-uftc8inx 878 19 a a DT cord-010092-uftc8inx 878 20 regional regional JJ cord-010092-uftc8inx 878 21 ( ( -LRB- cord-010092-uftc8inx 878 22 P p NN cord-010092-uftc8inx 878 23 < < XX cord-010092-uftc8inx 878 24 0.001 0.001 CD cord-010092-uftc8inx 878 25 ) ) -RRB- cord-010092-uftc8inx 878 26 and and CC cord-010092-uftc8inx 878 27 national national JJ cord-010092-uftc8inx 878 28 ( ( -LRB- cord-010092-uftc8inx 878 29 P p NN cord-010092-uftc8inx 878 30 < < XX cord-010092-uftc8inx 878 31 0.001 0.001 CD cord-010092-uftc8inx 878 32 ) ) -RRB- cord-010092-uftc8inx 878 33 basis basis NN cord-010092-uftc8inx 878 34 . . . cord-010092-uftc8inx 879 1 Summary Summary NNP cord-010092-uftc8inx 879 2 / / SYM cord-010092-uftc8inx 879 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 879 4 : : : cord-010092-uftc8inx 880 1 Regional regional JJ cord-010092-uftc8inx 880 2 and and CC cord-010092-uftc8inx 880 3 national national JJ cord-010092-uftc8inx 880 4 variation variation NN cord-010092-uftc8inx 880 5 exists exist VBZ cord-010092-uftc8inx 880 6 in in IN cord-010092-uftc8inx 880 7 platelet platelet NN cord-010092-uftc8inx 880 8 transfusion transfusion NN cord-010092-uftc8inx 880 9 practices practice NNS cord-010092-uftc8inx 880 10 among among IN cord-010092-uftc8inx 880 11 critically critically RB cord-010092-uftc8inx 880 12 ill ill JJ cord-010092-uftc8inx 880 13 children child NNS cord-010092-uftc8inx 880 14 , , , cord-010092-uftc8inx 880 15 especially especially RB cord-010092-uftc8inx 880 16 in in IN cord-010092-uftc8inx 880 17 those those DT cord-010092-uftc8inx 880 18 given give VBN cord-010092-uftc8inx 880 19 therapeutic therapeutic JJ cord-010092-uftc8inx 880 20 transfusions transfusion NNS cord-010092-uftc8inx 880 21 while while IN cord-010092-uftc8inx 880 22 supported support VBN cord-010092-uftc8inx 880 23 by by IN cord-010092-uftc8inx 880 24 ECLS ECLS NNP cord-010092-uftc8inx 880 25 . . . cord-010092-uftc8inx 881 1 Considering consider VBG cord-010092-uftc8inx 881 2 this this DT cord-010092-uftc8inx 881 3 variation variation NN cord-010092-uftc8inx 881 4 , , , cord-010092-uftc8inx 881 5 comparative comparative JJ cord-010092-uftc8inx 881 6 effectiveness effectiveness NN cord-010092-uftc8inx 881 7 studies study NNS cord-010092-uftc8inx 881 8 may may MD cord-010092-uftc8inx 881 9 be be VB cord-010092-uftc8inx 881 10 an an DT cord-010092-uftc8inx 881 11 appropriate appropriate JJ cord-010092-uftc8inx 881 12 approach approach NN cord-010092-uftc8inx 881 13 to to TO cord-010092-uftc8inx 881 14 gain gain VB cord-010092-uftc8inx 881 15 evidence evidence NN cord-010092-uftc8inx 881 16 to to TO cord-010092-uftc8inx 881 17 optimize optimize VB cord-010092-uftc8inx 881 18 platelet platelet NN cord-010092-uftc8inx 881 19 transfusion transfusion NN cord-010092-uftc8inx 881 20 thresholds threshold NNS cord-010092-uftc8inx 881 21 . . . cord-010092-uftc8inx 882 1 Background background NN cord-010092-uftc8inx 882 2 : : : cord-010092-uftc8inx 883 1 The the DT cord-010092-uftc8inx 883 2 optimal optimal JJ cord-010092-uftc8inx 883 3 threshold threshold NN cord-010092-uftc8inx 883 4 for for IN cord-010092-uftc8inx 883 5 prophylactic prophylactic JJ cord-010092-uftc8inx 883 6 platelet platelet NN cord-010092-uftc8inx 883 7 ( ( -LRB- cord-010092-uftc8inx 883 8 Plts Plts NNP cord-010092-uftc8inx 883 9 ) ) -RRB- cord-010092-uftc8inx 883 10 transfusion transfusion NN cord-010092-uftc8inx 883 11 in in IN cord-010092-uftc8inx 883 12 pediatric pediatric JJ cord-010092-uftc8inx 883 13 patients patient NNS cord-010092-uftc8inx 883 14 with with IN cord-010092-uftc8inx 883 15 cancer cancer NN cord-010092-uftc8inx 883 16 is be VBZ cord-010092-uftc8inx 883 17 still still RB cord-010092-uftc8inx 883 18 controversial controversial JJ cord-010092-uftc8inx 883 19 and and CC cord-010092-uftc8inx 883 20 current current JJ cord-010092-uftc8inx 883 21 clinical clinical JJ cord-010092-uftc8inx 883 22 practice practice NN cord-010092-uftc8inx 883 23 comes come VBZ cord-010092-uftc8inx 883 24 from from IN cord-010092-uftc8inx 883 25 studies study NNS cord-010092-uftc8inx 883 26 on on IN cord-010092-uftc8inx 883 27 adults adult NNS cord-010092-uftc8inx 883 28 and and CC cord-010092-uftc8inx 883 29 on on IN cord-010092-uftc8inx 883 30 inpatient inpatient JJ cord-010092-uftc8inx 883 31 setting setting NN cord-010092-uftc8inx 883 32 . . . cord-010092-uftc8inx 884 1 The the DT cord-010092-uftc8inx 884 2 international international JJ cord-010092-uftc8inx 884 3 guidelines guideline NNS cord-010092-uftc8inx 884 4 ( ( -LRB- cord-010092-uftc8inx 884 5 ICMTG ICMTG NNP cord-010092-uftc8inx 884 6 , , , cord-010092-uftc8inx 884 7 2015 2015 CD cord-010092-uftc8inx 884 8 ) ) -RRB- cord-010092-uftc8inx 884 9 recommend recommend VBP cord-010092-uftc8inx 884 10 , , , cord-010092-uftc8inx 884 11 for for IN cord-010092-uftc8inx 884 12 all all DT cord-010092-uftc8inx 884 13 age age NN cord-010092-uftc8inx 884 14 patients patient NNS cord-010092-uftc8inx 884 15 , , , cord-010092-uftc8inx 884 16 a a DT cord-010092-uftc8inx 884 17 prophylactic prophylactic JJ cord-010092-uftc8inx 884 18 platelet platelet NN cord-010092-uftc8inx 884 19 transfusion transfusion NN cord-010092-uftc8inx 884 20 when when WRB cord-010092-uftc8inx 884 21 Plts Plts NNP cord-010092-uftc8inx 884 22 count count NN cord-010092-uftc8inx 884 23 is be VBZ cord-010092-uftc8inx 884 24 ≤ ≤ NNP cord-010092-uftc8inx 884 25 10 10 CD cord-010092-uftc8inx 884 26 9 9 CD cord-010092-uftc8inx 884 27 10 10 CD cord-010092-uftc8inx 884 28 11 11 CD cord-010092-uftc8inx 884 29 /L /L . cord-010092-uftc8inx 884 30 and and CC cord-010092-uftc8inx 884 31 a a DT cord-010092-uftc8inx 884 32 platelet platelet NN cord-010092-uftc8inx 884 33 dose dose NN cord-010092-uftc8inx 884 34 of of IN cord-010092-uftc8inx 884 35 1.1 1.1 CD cord-010092-uftc8inx 884 36 9 9 CD cord-010092-uftc8inx 884 37 10 10 CD cord-010092-uftc8inx 884 38 11 11 CD cord-010092-uftc8inx 884 39 per per IN cord-010092-uftc8inx 884 40 square square JJ cord-010092-uftc8inx 884 41 meter meter NN cord-010092-uftc8inx 884 42 ( ( -LRB- cord-010092-uftc8inx 884 43 sm sm NN cord-010092-uftc8inx 884 44 ) ) -RRB- cord-010092-uftc8inx 884 45 of of IN cord-010092-uftc8inx 884 46 body body NN cord-010092-uftc8inx 884 47 - - HYPH cord-010092-uftc8inx 884 48 surface surface NN cord-010092-uftc8inx 884 49 area area NN cord-010092-uftc8inx 884 50 ( ( -LRB- cord-010092-uftc8inx 884 51 BSA BSA NNP cord-010092-uftc8inx 884 52 ) ) -RRB- cord-010092-uftc8inx 884 53 in in IN cord-010092-uftc8inx 884 54 inpatient inpatient NN cord-010092-uftc8inx 884 55 and and CC cord-010092-uftc8inx 884 56 2.2 2.2 CD cord-010092-uftc8inx 884 57 9 9 CD cord-010092-uftc8inx 884 58 10 10 CD cord-010092-uftc8inx 884 59 11 11 CD cord-010092-uftc8inx 884 60 /sm /sm . cord-010092-uftc8inx 884 61 in in IN cord-010092-uftc8inx 884 62 outpatient outpatient NN cord-010092-uftc8inx 884 63 setting setting NN cord-010092-uftc8inx 884 64 . . . cord-010092-uftc8inx 885 1 Aims aim VBZ cord-010092-uftc8inx 885 2 : : : cord-010092-uftc8inx 886 1 In in IN cord-010092-uftc8inx 886 2 January January NNP cord-010092-uftc8inx 886 3 2018 2018 CD cord-010092-uftc8inx 886 4 we -PRON- PRP cord-010092-uftc8inx 886 5 started start VBD cord-010092-uftc8inx 886 6 in in IN cord-010092-uftc8inx 886 7 our -PRON- PRP$ cord-010092-uftc8inx 886 8 Children Children NNP cord-010092-uftc8inx 886 9 's 's POS cord-010092-uftc8inx 886 10 Hospital Hospital NNP cord-010092-uftc8inx 886 11 a a DT cord-010092-uftc8inx 886 12 prospective prospective JJ cord-010092-uftc8inx 886 13 protocol protocol NN cord-010092-uftc8inx 886 14 in in IN cord-010092-uftc8inx 886 15 order order NN cord-010092-uftc8inx 886 16 to to TO cord-010092-uftc8inx 886 17 evaluate evaluate VB cord-010092-uftc8inx 886 18 the the DT cord-010092-uftc8inx 886 19 impact impact NN cord-010092-uftc8inx 886 20 on on IN cord-010092-uftc8inx 886 21 bleeding bleed VBG cord-010092-uftc8inx 886 22 risk risk NN cord-010092-uftc8inx 886 23 of of IN cord-010092-uftc8inx 886 24 current current JJ cord-010092-uftc8inx 886 25 clinical clinical JJ cord-010092-uftc8inx 886 26 practice practice NN cord-010092-uftc8inx 886 27 of of IN cord-010092-uftc8inx 886 28 prophylactic prophylactic JJ cord-010092-uftc8inx 886 29 platelet platelet NN cord-010092-uftc8inx 886 30 transfusion transfusion NN cord-010092-uftc8inx 886 31 in in IN cord-010092-uftc8inx 886 32 inpatients inpatient NNS cord-010092-uftc8inx 886 33 and and CC cord-010092-uftc8inx 886 34 outpatients outpatient NNS cord-010092-uftc8inx 886 35 onco onco JJ cord-010092-uftc8inx 886 36 - - HYPH cord-010092-uftc8inx 886 37 haematological haematological NN cord-010092-uftc8inx 886 38 patients patient NNS cord-010092-uftc8inx 886 39 . . . cord-010092-uftc8inx 887 1 Methods method NNS cord-010092-uftc8inx 887 2 : : : cord-010092-uftc8inx 888 1 BSA BSA NNP cord-010092-uftc8inx 888 2 was be VBD cord-010092-uftc8inx 888 3 calculated calculate VBN cord-010092-uftc8inx 888 4 from from IN cord-010092-uftc8inx 888 5 age age NN cord-010092-uftc8inx 888 6 - - HYPH cord-010092-uftc8inx 888 7 standardized standardize VBN cord-010092-uftc8inx 888 8 weight weight NN cord-010092-uftc8inx 888 9 . . . cord-010092-uftc8inx 889 1 Inpatients inpatient NNS cord-010092-uftc8inx 889 2 received receive VBD cord-010092-uftc8inx 889 3 a a DT cord-010092-uftc8inx 889 4 dose dose NN cord-010092-uftc8inx 889 5 per per IN cord-010092-uftc8inx 889 6 transfusion transfusion NN cord-010092-uftc8inx 889 7 of of IN cord-010092-uftc8inx 889 8 1.1 1.1 CD cord-010092-uftc8inx 889 9 9 9 CD cord-010092-uftc8inx 889 10 10 10 CD cord-010092-uftc8inx 889 11 11 11 CD cord-010092-uftc8inx 889 12 /sm /sm , cord-010092-uftc8inx 889 13 and and CC cord-010092-uftc8inx 889 14 Outpatients outpatient NNS cord-010092-uftc8inx 889 15 a a DT cord-010092-uftc8inx 889 16 dose dose NN cord-010092-uftc8inx 889 17 per per IN cord-010092-uftc8inx 889 18 transfusion transfusion NN cord-010092-uftc8inx 889 19 of of IN cord-010092-uftc8inx 889 20 2.2 2.2 CD cord-010092-uftc8inx 889 21 9 9 CD cord-010092-uftc8inx 889 22 10 10 CD cord-010092-uftc8inx 889 23 11 11 CD cord-010092-uftc8inx 889 24 /sm /sm . cord-010092-uftc8inx 889 25 . . . cord-010092-uftc8inx 890 1 Platelets platelet NNS cord-010092-uftc8inx 890 2 were be VBD cord-010092-uftc8inx 890 3 transfused transfuse VBN cord-010092-uftc8inx 890 4 when when WRB cord-010092-uftc8inx 890 5 the the DT cord-010092-uftc8inx 890 6 count count NN cord-010092-uftc8inx 890 7 was be VBD cord-010092-uftc8inx 890 8 ≤ ≤ NNP cord-010092-uftc8inx 890 9 10 10 CD cord-010092-uftc8inx 890 10 9 9 CD cord-010092-uftc8inx 890 11 10 10 CD cord-010092-uftc8inx 890 12 11 11 CD cord-010092-uftc8inx 890 13 /L /L , cord-010092-uftc8inx 890 14 or or CC cord-010092-uftc8inx 890 15 in in IN cord-010092-uftc8inx 890 16 presence presence NN cord-010092-uftc8inx 890 17 of of IN cord-010092-uftc8inx 890 18 bleeding bleed VBG cord-010092-uftc8inx 890 19 signs sign NNS cord-010092-uftc8inx 890 20 ; ; : cord-010092-uftc8inx 890 21 pediatric pediatric JJ cord-010092-uftc8inx 890 22 aliquots aliquot NNS cord-010092-uftc8inx 890 23 were be VBD cord-010092-uftc8inx 890 24 obtained obtain VBN cord-010092-uftc8inx 890 25 from from IN cord-010092-uftc8inx 890 26 Buffy Buffy NNP cord-010092-uftc8inx 890 27 coat coat NN cord-010092-uftc8inx 890 28 derived derive VBD cord-010092-uftc8inx 890 29 pooled pool VBN cord-010092-uftc8inx 890 30 platelet platelet NN cord-010092-uftc8inx 890 31 concentrates concentrate NNS cord-010092-uftc8inx 890 32 or or CC cord-010092-uftc8inx 890 33 apheresis apheresis NN cord-010092-uftc8inx 890 34 platelet platelet NN cord-010092-uftc8inx 890 35 concentrates concentrate VBZ cord-010092-uftc8inx 890 36 , , , cord-010092-uftc8inx 890 37 according accord VBG cord-010092-uftc8inx 890 38 disponibility disponibility NN cord-010092-uftc8inx 890 39 . . . cord-010092-uftc8inx 891 1 Results result NNS cord-010092-uftc8inx 891 2 : : : cord-010092-uftc8inx 892 1 From from IN cord-010092-uftc8inx 892 2 January January NNP cord-010092-uftc8inx 892 3 2018 2018 CD cord-010092-uftc8inx 892 4 to to IN cord-010092-uftc8inx 892 5 December December NNP cord-010092-uftc8inx 892 6 2018 2018 CD cord-010092-uftc8inx 892 7 a a DT cord-010092-uftc8inx 892 8 total total NN cord-010092-uftc8inx 892 9 of of IN cord-010092-uftc8inx 892 10 9839 9839 CD cord-010092-uftc8inx 892 11 platelet platelet NN cord-010092-uftc8inx 892 12 pediatric pediatric JJ cord-010092-uftc8inx 892 13 aliquots aliquot NNS cord-010092-uftc8inx 892 14 were be VBD cord-010092-uftc8inx 892 15 transfused transfuse VBN cord-010092-uftc8inx 892 16 : : : cord-010092-uftc8inx 892 17 5534 5534 CD cord-010092-uftc8inx 892 18 ( ( -LRB- cord-010092-uftc8inx 892 19 56.2 56.2 CD cord-010092-uftc8inx 892 20 % % NN cord-010092-uftc8inx 892 21 ) ) -RRB- cord-010092-uftc8inx 892 22 were be VBD cord-010092-uftc8inx 892 23 obtained obtain VBN cord-010092-uftc8inx 892 24 from from IN cord-010092-uftc8inx 892 25 apheresis apheresis NN cord-010092-uftc8inx 892 26 platelet platelet NN cord-010092-uftc8inx 892 27 concentrates concentrate VBZ cord-010092-uftc8inx 892 28 and and CC cord-010092-uftc8inx 892 29 4305 4305 CD cord-010092-uftc8inx 892 30 ( ( -LRB- cord-010092-uftc8inx 892 31 43.8 43.8 CD cord-010092-uftc8inx 892 32 % % NN cord-010092-uftc8inx 892 33 ) ) -RRB- cord-010092-uftc8inx 892 34 from from IN cord-010092-uftc8inx 892 35 Buffy Buffy NNP cord-010092-uftc8inx 892 36 - - HYPH cord-010092-uftc8inx 892 37 coat coat NN cord-010092-uftc8inx 892 38 - - HYPH cord-010092-uftc8inx 892 39 derived derive VBN cord-010092-uftc8inx 892 40 pooled pool VBN cord-010092-uftc8inx 892 41 platelet platelet NN cord-010092-uftc8inx 892 42 concentrates concentrate VBZ cord-010092-uftc8inx 892 43 . . . cord-010092-uftc8inx 893 1 The the DT cord-010092-uftc8inx 893 2 majority majority NN cord-010092-uftc8inx 893 3 of of IN cord-010092-uftc8inx 893 4 platelets platelet NNS cord-010092-uftc8inx 893 5 pediatric pediatric JJ cord-010092-uftc8inx 893 6 aliquots aliquot NNS cord-010092-uftc8inx 893 7 ( ( -LRB- cord-010092-uftc8inx 893 8 7505 7505 CD cord-010092-uftc8inx 893 9 - - HYPH cord-010092-uftc8inx 893 10 76.3 76.3 CD cord-010092-uftc8inx 893 11 % % NN cord-010092-uftc8inx 893 12 ) ) -RRB- cord-010092-uftc8inx 893 13 were be VBD cord-010092-uftc8inx 893 14 transfused transfuse VBN cord-010092-uftc8inx 893 15 to to IN cord-010092-uftc8inx 893 16 onco onco JJ cord-010092-uftc8inx 893 17 - - HYPH cord-010092-uftc8inx 893 18 hematological hematological JJ cord-010092-uftc8inx 893 19 patients patient NNS cord-010092-uftc8inx 893 20 undergoing undergo VBG cord-010092-uftc8inx 893 21 hematopoietic hematopoietic JJ cord-010092-uftc8inx 893 22 stem stem NN cord-010092-uftc8inx 893 23 cells cell NNS cord-010092-uftc8inx 893 24 transplant transplant NN cord-010092-uftc8inx 893 25 ( ( -LRB- cord-010092-uftc8inx 893 26 HSCT HSCT NNP cord-010092-uftc8inx 893 27 ) ) -RRB- cord-010092-uftc8inx 893 28 or or CC cord-010092-uftc8inx 893 29 conventional conventional JJ cord-010092-uftc8inx 893 30 chemotherapy chemotherapy NN cord-010092-uftc8inx 893 31 . . . cord-010092-uftc8inx 894 1 Among among IN cord-010092-uftc8inx 894 2 them -PRON- PRP cord-010092-uftc8inx 894 3 , , , cord-010092-uftc8inx 894 4 6365 6365 CD cord-010092-uftc8inx 894 5 aliquots aliquot NNS cord-010092-uftc8inx 894 6 were be VBD cord-010092-uftc8inx 894 7 transfused transfuse VBN cord-010092-uftc8inx 894 8 in in IN cord-010092-uftc8inx 894 9 inpatient inpatient JJ cord-010092-uftc8inx 894 10 setting setting NN cord-010092-uftc8inx 894 11 : : : cord-010092-uftc8inx 894 12 1675 1675 CD cord-010092-uftc8inx 894 13 ( ( -LRB- cord-010092-uftc8inx 894 14 17 17 CD cord-010092-uftc8inx 894 15 % % NN cord-010092-uftc8inx 894 16 ) ) -RRB- cord-010092-uftc8inx 894 17 in in IN cord-010092-uftc8inx 894 18 the the DT cord-010092-uftc8inx 894 19 hematology hematology NN cord-010092-uftc8inx 894 20 unit unit NN cord-010092-uftc8inx 894 21 , , , cord-010092-uftc8inx 894 22 2772 2772 CD cord-010092-uftc8inx 894 23 ( ( -LRB- cord-010092-uftc8inx 894 24 28.2 28.2 CD cord-010092-uftc8inx 894 25 % % NN cord-010092-uftc8inx 894 26 ) ) -RRB- cord-010092-uftc8inx 894 27 in in IN cord-010092-uftc8inx 894 28 the the DT cord-010092-uftc8inx 894 29 oncology oncology NN cord-010092-uftc8inx 894 30 unit unit NN cord-010092-uftc8inx 894 31 and and CC cord-010092-uftc8inx 894 32 1918 1918 CD cord-010092-uftc8inx 894 33 ( ( -LRB- cord-010092-uftc8inx 894 34 19.5 19.5 CD cord-010092-uftc8inx 894 35 % % NN cord-010092-uftc8inx 894 36 ) ) -RRB- cord-010092-uftc8inx 894 37 in in IN cord-010092-uftc8inx 894 38 HSCT HSCT NNP cord-010092-uftc8inx 894 39 unit unit NN cord-010092-uftc8inx 894 40 . . . cord-010092-uftc8inx 895 1 A a DT cord-010092-uftc8inx 895 2 total total NN cord-010092-uftc8inx 895 3 of of IN cord-010092-uftc8inx 895 4 1140 1140 CD cord-010092-uftc8inx 895 5 ( ( -LRB- cord-010092-uftc8inx 895 6 11.5 11.5 CD cord-010092-uftc8inx 895 7 % % NN cord-010092-uftc8inx 895 8 ) ) -RRB- cord-010092-uftc8inx 895 9 aliquots aliquot NNS cord-010092-uftc8inx 895 10 were be VBD cord-010092-uftc8inx 895 11 transfused transfuse VBN cord-010092-uftc8inx 895 12 in in IN cord-010092-uftc8inx 895 13 outpatient outpatient NN cord-010092-uftc8inx 895 14 setting setting NN cord-010092-uftc8inx 895 15 : : : cord-010092-uftc8inx 895 16 840 840 CD cord-010092-uftc8inx 895 17 ( ( -LRB- cord-010092-uftc8inx 895 18 8.5 8.5 CD cord-010092-uftc8inx 895 19 % % NN cord-010092-uftc8inx 895 20 ) ) -RRB- cord-010092-uftc8inx 895 21 to to IN cord-010092-uftc8inx 895 22 patients patient NNS cord-010092-uftc8inx 895 23 affected affect VBN cord-010092-uftc8inx 895 24 by by IN cord-010092-uftc8inx 895 25 hematological hematological JJ cord-010092-uftc8inx 895 26 malignancies malignancy NNS cord-010092-uftc8inx 895 27 and and CC cord-010092-uftc8inx 895 28 300 300 CD cord-010092-uftc8inx 895 29 ( ( -LRB- cord-010092-uftc8inx 895 30 3 3 CD cord-010092-uftc8inx 895 31 % % NN cord-010092-uftc8inx 895 32 ) ) -RRB- cord-010092-uftc8inx 895 33 to to IN cord-010092-uftc8inx 895 34 patients patient NNS cord-010092-uftc8inx 895 35 with with IN cord-010092-uftc8inx 895 36 solid solid JJ cord-010092-uftc8inx 895 37 tumors tumor NNS cord-010092-uftc8inx 895 38 . . . cord-010092-uftc8inx 896 1 Five five CD cord-010092-uftc8inx 896 2 major major JJ cord-010092-uftc8inx 896 3 bleeding bleed VBG cord-010092-uftc8inx 896 4 events event NNS cord-010092-uftc8inx 896 5 ( ( -LRB- cord-010092-uftc8inx 896 6 WHO who WP cord-010092-uftc8inx 896 7 grade grade NN cord-010092-uftc8inx 896 8 ≥ ≥ NNP cord-010092-uftc8inx 896 9 3 3 CD cord-010092-uftc8inx 896 10 ) ) -RRB- cord-010092-uftc8inx 896 11 were be VBD cord-010092-uftc8inx 896 12 observed observe VBN cord-010092-uftc8inx 896 13 during during IN cord-010092-uftc8inx 896 14 the the DT cord-010092-uftc8inx 896 15 study study NN cord-010092-uftc8inx 896 16 period period NN cord-010092-uftc8inx 896 17 and and CC cord-010092-uftc8inx 896 18 all all DT cord-010092-uftc8inx 896 19 of of IN cord-010092-uftc8inx 896 20 them -PRON- PRP cord-010092-uftc8inx 896 21 occurred occur VBD cord-010092-uftc8inx 896 22 in in IN cord-010092-uftc8inx 896 23 hospitalized hospitalize VBN cord-010092-uftc8inx 896 24 patients patient NNS cord-010092-uftc8inx 896 25 . . . cord-010092-uftc8inx 897 1 Two two CD cord-010092-uftc8inx 897 2 patients patient NNS cord-010092-uftc8inx 897 3 with with IN cord-010092-uftc8inx 897 4 solid solid JJ cord-010092-uftc8inx 897 5 neoplasm neoplasm NN cord-010092-uftc8inx 897 6 developed develop VBD cord-010092-uftc8inx 897 7 a a DT cord-010092-uftc8inx 897 8 WHO WHO NNP cord-010092-uftc8inx 897 9 grade grade NN cord-010092-uftc8inx 897 10 3 3 CD cord-010092-uftc8inx 897 11 bleeding bleeding NN cord-010092-uftc8inx 897 12 event event NN cord-010092-uftc8inx 897 13 . . . cord-010092-uftc8inx 898 1 Two two CD cord-010092-uftc8inx 898 2 patients patient NNS cord-010092-uftc8inx 898 3 with with IN cord-010092-uftc8inx 898 4 hematologic hematologic JJ cord-010092-uftc8inx 898 5 malignancies malignancy NNS cord-010092-uftc8inx 898 6 and and CC cord-010092-uftc8inx 898 7 a a DT cord-010092-uftc8inx 898 8 patient patient NN cord-010092-uftc8inx 898 9 with with IN cord-010092-uftc8inx 898 10 neuroblastoma neuroblastoma NN cord-010092-uftc8inx 898 11 ( ( -LRB- cord-010092-uftc8inx 898 12 n n NN cord-010092-uftc8inx 898 13 = = SYM cord-010092-uftc8inx 898 14 3 3 CD cord-010092-uftc8inx 898 15 , , , cord-010092-uftc8inx 898 16 1.2 1.2 CD cord-010092-uftc8inx 898 17 % % NN cord-010092-uftc8inx 898 18 ) ) -RRB- cord-010092-uftc8inx 898 19 developed develop VBN cord-010092-uftc8inx 898 20 intracranial intracranial JJ cord-010092-uftc8inx 898 21 bleeding bleeding NN cord-010092-uftc8inx 898 22 ( ( -LRB- cord-010092-uftc8inx 898 23 WHO who WP cord-010092-uftc8inx 898 24 grade grade NN cord-010092-uftc8inx 898 25 4 4 CD cord-010092-uftc8inx 898 26 ) ) -RRB- cord-010092-uftc8inx 898 27 . . . cord-010092-uftc8inx 899 1 The the DT cord-010092-uftc8inx 899 2 platelet platelet NN cord-010092-uftc8inx 899 3 count count NN cord-010092-uftc8inx 899 4 at at IN cord-010092-uftc8inx 899 5 the the DT cord-010092-uftc8inx 899 6 time time NN cord-010092-uftc8inx 899 7 of of IN cord-010092-uftc8inx 899 8 the the DT cord-010092-uftc8inx 899 9 event event NN cord-010092-uftc8inx 899 10 was be VBD cord-010092-uftc8inx 899 11 22 22 CD cord-010092-uftc8inx 899 12 9 9 CD cord-010092-uftc8inx 899 13 10 10 CD cord-010092-uftc8inx 899 14 9 9 CD cord-010092-uftc8inx 899 15 /L /l CD cord-010092-uftc8inx 899 16 , , , cord-010092-uftc8inx 899 17 25 25 CD cord-010092-uftc8inx 899 18 9 9 CD cord-010092-uftc8inx 899 19 10 10 CD cord-010092-uftc8inx 899 20 9 9 CD cord-010092-uftc8inx 899 21 /L /l CD cord-010092-uftc8inx 899 22 and and CC cord-010092-uftc8inx 899 23 8 8 CD cord-010092-uftc8inx 899 24 9 9 CD cord-010092-uftc8inx 899 25 10 10 CD cord-010092-uftc8inx 899 26 9 9 CD cord-010092-uftc8inx 899 27 /L /l CD cord-010092-uftc8inx 899 28 , , , cord-010092-uftc8inx 899 29 respectively respectively RB cord-010092-uftc8inx 899 30 . . . cord-010092-uftc8inx 900 1 Summary Summary NNP cord-010092-uftc8inx 900 2 / / SYM cord-010092-uftc8inx 900 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 900 4 : : : cord-010092-uftc8inx 901 1 Our -PRON- PRP$ cord-010092-uftc8inx 901 2 results result NNS cord-010092-uftc8inx 901 3 showed show VBD cord-010092-uftc8inx 901 4 the the DT cord-010092-uftc8inx 901 5 efficacy efficacy NN cord-010092-uftc8inx 901 6 , , , cord-010092-uftc8inx 901 7 in in IN cord-010092-uftc8inx 901 8 onco onco JJ cord-010092-uftc8inx 901 9 - - HYPH cord-010092-uftc8inx 901 10 hematological hematological JJ cord-010092-uftc8inx 901 11 pediatric pediatric JJ cord-010092-uftc8inx 901 12 patients patient NNS cord-010092-uftc8inx 901 13 , , , cord-010092-uftc8inx 901 14 of of IN cord-010092-uftc8inx 901 15 a a DT cord-010092-uftc8inx 901 16 prophylactic prophylactic JJ cord-010092-uftc8inx 901 17 platelet platelet NN cord-010092-uftc8inx 901 18 transfusion transfusion NN cord-010092-uftc8inx 901 19 protocol protocol NN cord-010092-uftc8inx 901 20 based base VBN cord-010092-uftc8inx 901 21 on on IN cord-010092-uftc8inx 901 22 international international JJ cord-010092-uftc8inx 901 23 guidelines guideline NNS cord-010092-uftc8inx 901 24 : : : cord-010092-uftc8inx 901 25 a a DT cord-010092-uftc8inx 901 26 very very RB cord-010092-uftc8inx 901 27 low low JJ cord-010092-uftc8inx 901 28 incidence incidence NN cord-010092-uftc8inx 901 29 of of IN cord-010092-uftc8inx 901 30 WHO WHO NNP cord-010092-uftc8inx 901 31 grade grade NN cord-010092-uftc8inx 901 32 4 4 CD cord-010092-uftc8inx 901 33 bleeding bleeding NN cord-010092-uftc8inx 901 34 has have VBZ cord-010092-uftc8inx 901 35 been be VBN cord-010092-uftc8inx 901 36 observed observe VBN cord-010092-uftc8inx 901 37 in in IN cord-010092-uftc8inx 901 38 inpatients inpatient NNS cord-010092-uftc8inx 901 39 setting set VBG cord-010092-uftc8inx 901 40 only only RB cord-010092-uftc8inx 901 41 ( ( -LRB- cord-010092-uftc8inx 901 42 1.2 1.2 CD cord-010092-uftc8inx 901 43 % % NN cord-010092-uftc8inx 901 44 vs vs IN cord-010092-uftc8inx 901 45 1 1 CD cord-010092-uftc8inx 901 46 % % NN cord-010092-uftc8inx 901 47 of of IN cord-010092-uftc8inx 901 48 PLADO PLADO NNP cord-010092-uftc8inx 901 49 Trial Trial NNP cord-010092-uftc8inx 901 50 , , , cord-010092-uftc8inx 901 51 SJ SJ NNP cord-010092-uftc8inx 901 52 Slichter Slichter NNP cord-010092-uftc8inx 901 53 , , , cord-010092-uftc8inx 901 54 NEJM NEJM NNP cord-010092-uftc8inx 901 55 , , , cord-010092-uftc8inx 901 56 2010 2010 CD cord-010092-uftc8inx 901 57 ) ) -RRB- cord-010092-uftc8inx 901 58 , , , cord-010092-uftc8inx 901 59 while while IN cord-010092-uftc8inx 901 60 in in IN cord-010092-uftc8inx 901 61 outpatients outpatient NNS cord-010092-uftc8inx 901 62 setting set VBG cord-010092-uftc8inx 901 63 the the DT cord-010092-uftc8inx 901 64 double double JJ cord-010092-uftc8inx 901 65 platelet platelet NN cord-010092-uftc8inx 901 66 dose dose NN cord-010092-uftc8inx 901 67 prevents prevent VBZ cord-010092-uftc8inx 901 68 the the DT cord-010092-uftc8inx 901 69 major major JJ cord-010092-uftc8inx 901 70 bleeding bleed VBG cord-010092-uftc8inx 901 71 event event NN cord-010092-uftc8inx 901 72 ( ( -LRB- cord-010092-uftc8inx 901 73 WHO who WP cord-010092-uftc8inx 901 74 grade grade NN cord-010092-uftc8inx 901 75 ≥ ≥ NNP cord-010092-uftc8inx 901 76 3 3 CD cord-010092-uftc8inx 901 77 ) ) -RRB- cord-010092-uftc8inx 901 78 occurrence occurrence NN cord-010092-uftc8inx 901 79 . . . cord-010092-uftc8inx 902 1 Background background NN cord-010092-uftc8inx 902 2 : : : cord-010092-uftc8inx 903 1 The the DT cord-010092-uftc8inx 903 2 problem problem NN cord-010092-uftc8inx 903 3 of of IN cord-010092-uftc8inx 903 4 blood blood NN cord-010092-uftc8inx 903 5 - - HYPH cord-010092-uftc8inx 903 6 borne bear VBN cord-010092-uftc8inx 903 7 infections infection NNS cord-010092-uftc8inx 903 8 remains remain VBZ cord-010092-uftc8inx 903 9 relevant relevant JJ cord-010092-uftc8inx 903 10 in in IN cord-010092-uftc8inx 903 11 transfusion transfusion NN cord-010092-uftc8inx 903 12 medicine medicine NN cord-010092-uftc8inx 903 13 . . . cord-010092-uftc8inx 904 1 Pathogen pathogen NN cord-010092-uftc8inx 904 2 reduction reduction NN cord-010092-uftc8inx 904 3 technologies technology NNS cord-010092-uftc8inx 904 4 ( ( -LRB- cord-010092-uftc8inx 904 5 PRT PRT NNP cord-010092-uftc8inx 904 6 ) ) -RRB- cord-010092-uftc8inx 904 7 provide provide VBP cord-010092-uftc8inx 904 8 a a DT cord-010092-uftc8inx 904 9 preventive preventive JJ cord-010092-uftc8inx 904 10 approach approach NN cord-010092-uftc8inx 904 11 to to IN cord-010092-uftc8inx 904 12 a a DT cord-010092-uftc8inx 904 13 wide wide JJ cord-010092-uftc8inx 904 14 range range NN cord-010092-uftc8inx 904 15 of of IN cord-010092-uftc8inx 904 16 transfusion transfusion NN cord-010092-uftc8inx 904 17 - - HYPH cord-010092-uftc8inx 904 18 transmitted transmit VBN cord-010092-uftc8inx 904 19 infectious infectious JJ cord-010092-uftc8inx 904 20 diseases disease NNS cord-010092-uftc8inx 904 21 . . . cord-010092-uftc8inx 905 1 To to IN cord-010092-uftc8inx 905 2 date date NN cord-010092-uftc8inx 905 3 , , , cord-010092-uftc8inx 905 4 PRT PRT NNP cord-010092-uftc8inx 905 5 widely widely RB cord-010092-uftc8inx 905 6 used use VBD cord-010092-uftc8inx 905 7 for for IN cord-010092-uftc8inx 905 8 platelet platelet NN cord-010092-uftc8inx 905 9 concentrates concentrate NNS cord-010092-uftc8inx 905 10 and and CC cord-010092-uftc8inx 905 11 blood blood NN cord-010092-uftc8inx 905 12 plasma plasma NN cord-010092-uftc8inx 905 13 , , , cord-010092-uftc8inx 905 14 however however RB cord-010092-uftc8inx 905 15 , , , cord-010092-uftc8inx 905 16 the the DT cord-010092-uftc8inx 905 17 use use NN cord-010092-uftc8inx 905 18 of of IN cord-010092-uftc8inx 905 19 these these DT cord-010092-uftc8inx 905 20 technologies technology NNS cord-010092-uftc8inx 905 21 for for IN cord-010092-uftc8inx 905 22 the the DT cord-010092-uftc8inx 905 23 treatment treatment NN cord-010092-uftc8inx 905 24 of of IN cord-010092-uftc8inx 905 25 red red JJ cord-010092-uftc8inx 905 26 blood blood NN cord-010092-uftc8inx 905 27 cell cell NN cord-010092-uftc8inx 905 28 - - HYPH cord-010092-uftc8inx 905 29 containing contain VBG cord-010092-uftc8inx 905 30 blood blood NN cord-010092-uftc8inx 905 31 products product NNS cord-010092-uftc8inx 905 32 undergo undergo VBP cord-010092-uftc8inx 905 33 research research NN cord-010092-uftc8inx 905 34 . . . cord-010092-uftc8inx 906 1 Aims aim VBZ cord-010092-uftc8inx 906 2 : : : cord-010092-uftc8inx 907 1 The the DT cord-010092-uftc8inx 907 2 aim aim NN cord-010092-uftc8inx 907 3 of of IN cord-010092-uftc8inx 907 4 our -PRON- PRP$ cord-010092-uftc8inx 907 5 study study NN cord-010092-uftc8inx 907 6 was be VBD cord-010092-uftc8inx 907 7 to to TO cord-010092-uftc8inx 907 8 evaluate evaluate VB cord-010092-uftc8inx 907 9 the the DT cord-010092-uftc8inx 907 10 safety safety NN cord-010092-uftc8inx 907 11 and and CC cord-010092-uftc8inx 907 12 efficacy efficacy NN cord-010092-uftc8inx 907 13 of of IN cord-010092-uftc8inx 907 14 transfusions transfusion NNS cord-010092-uftc8inx 907 15 of of IN cord-010092-uftc8inx 907 16 pathogen pathogen NN cord-010092-uftc8inx 907 17 - - HYPH cord-010092-uftc8inx 907 18 reduced reduce VBN cord-010092-uftc8inx 907 19 ( ( -LRB- cord-010092-uftc8inx 907 20 test test NN cord-010092-uftc8inx 907 21 group group NN cord-010092-uftc8inx 907 22 ) ) -RRB- cord-010092-uftc8inx 907 23 red red JJ cord-010092-uftc8inx 907 24 blood blood NN cord-010092-uftc8inx 907 25 cell cell NN cord-010092-uftc8inx 907 26 suspensions suspension NNS cord-010092-uftc8inx 907 27 ( ( -LRB- cord-010092-uftc8inx 907 28 RBCS rbc NNS cord-010092-uftc8inx 907 29 ) ) -RRB- cord-010092-uftc8inx 907 30 and and CC cord-010092-uftc8inx 907 31 compare compare VB cord-010092-uftc8inx 907 32 these these DT cord-010092-uftc8inx 907 33 data datum NNS cord-010092-uftc8inx 907 34 with with IN cord-010092-uftc8inx 907 35 gamma gamma NN cord-010092-uftc8inx 907 36 - - HYPH cord-010092-uftc8inx 907 37 irradiated irradiate VBN cord-010092-uftc8inx 907 38 RBCS RBCS NNP cord-010092-uftc8inx 907 39 ( ( -LRB- cord-010092-uftc8inx 907 40 control control NN cord-010092-uftc8inx 907 41 group group NN cord-010092-uftc8inx 907 42 ) ) -RRB- cord-010092-uftc8inx 907 43 . . . cord-010092-uftc8inx 908 1 Methods method NNS cord-010092-uftc8inx 908 2 : : : cord-010092-uftc8inx 909 1 The the DT cord-010092-uftc8inx 909 2 technology technology NN cord-010092-uftc8inx 909 3 based base VBN cord-010092-uftc8inx 909 4 on on IN cord-010092-uftc8inx 909 5 the the DT cord-010092-uftc8inx 909 6 combined combine VBN cord-010092-uftc8inx 909 7 action action NN cord-010092-uftc8inx 909 8 of of IN cord-010092-uftc8inx 909 9 riboflavin riboflavin NN cord-010092-uftc8inx 909 10 and and CC cord-010092-uftc8inx 909 11 ultraviolet ultraviolet NN cord-010092-uftc8inx 909 12 ( ( -LRB- cord-010092-uftc8inx 909 13 Mirasol Mirasol NNP cord-010092-uftc8inx 909 14 PRT PRT NNP cord-010092-uftc8inx 909 15 , , , cord-010092-uftc8inx 909 16 Terumo Terumo NNP cord-010092-uftc8inx 909 17 BCT BCT NNP cord-010092-uftc8inx 909 18 , , , cord-010092-uftc8inx 909 19 Belgium Belgium NNP cord-010092-uftc8inx 909 20 ) ) -RRB- cord-010092-uftc8inx 909 21 was be VBD cord-010092-uftc8inx 909 22 used use VBN cord-010092-uftc8inx 909 23 to to TO cord-010092-uftc8inx 909 24 reduce reduce VB cord-010092-uftc8inx 909 25 pathogens pathogen NNS cord-010092-uftc8inx 909 26 in in IN cord-010092-uftc8inx 909 27 whole whole JJ cord-010092-uftc8inx 909 28 blood blood NN cord-010092-uftc8inx 909 29 . . . cord-010092-uftc8inx 910 1 Subsequently subsequently RB cord-010092-uftc8inx 910 2 , , , cord-010092-uftc8inx 910 3 the the DT cord-010092-uftc8inx 910 4 RBCS rbc NNS cord-010092-uftc8inx 910 5 of of IN cord-010092-uftc8inx 910 6 the the DT cord-010092-uftc8inx 910 7 test test NN cord-010092-uftc8inx 910 8 group group NN cord-010092-uftc8inx 910 9 were be VBD cord-010092-uftc8inx 910 10 derived derive VBN cord-010092-uftc8inx 910 11 from from IN cord-010092-uftc8inx 910 12 pathogenreduced pathogenreduced JJ cord-010092-uftc8inx 910 13 whole whole JJ cord-010092-uftc8inx 910 14 blood blood NN cord-010092-uftc8inx 910 15 . . . cord-010092-uftc8inx 911 1 The the DT cord-010092-uftc8inx 911 2 control control NN cord-010092-uftc8inx 911 3 RBCS rbc NNS cord-010092-uftc8inx 911 4 were be VBD cord-010092-uftc8inx 911 5 irradiated irradiate VBN cord-010092-uftc8inx 911 6 at at IN cord-010092-uftc8inx 911 7 the the DT cord-010092-uftc8inx 911 8 GammaCell GammaCell NNP cord-010092-uftc8inx 911 9 3000 3000 CD cord-010092-uftc8inx 911 10 Elite Elite NNP cord-010092-uftc8inx 911 11 ( ( -LRB- cord-010092-uftc8inx 911 12 Best Best NNP cord-010092-uftc8inx 911 13 Theratronics Theratronics NNPS cord-010092-uftc8inx 911 14 , , , cord-010092-uftc8inx 911 15 Canada Canada NNP cord-010092-uftc8inx 911 16 ) ) -RRB- cord-010092-uftc8inx 911 17 at at IN cord-010092-uftc8inx 911 18 a a DT cord-010092-uftc8inx 911 19 dose dose NN cord-010092-uftc8inx 911 20 of of IN cord-010092-uftc8inx 911 21 25 25 CD cord-010092-uftc8inx 911 22 Gray Gray NNP cord-010092-uftc8inx 911 23 . . . cord-010092-uftc8inx 912 1 All all DT cord-010092-uftc8inx 912 2 RBCS rbc NNS cord-010092-uftc8inx 912 3 were be VBD cord-010092-uftc8inx 912 4 used use VBN cord-010092-uftc8inx 912 5 for for IN cord-010092-uftc8inx 912 6 transfusion transfusion NN cord-010092-uftc8inx 912 7 for for IN cord-010092-uftc8inx 912 8 14 14 CD cord-010092-uftc8inx 912 9 days day NNS cord-010092-uftc8inx 912 10 from from IN cord-010092-uftc8inx 912 11 the the DT cord-010092-uftc8inx 912 12 harvest harvest NN cord-010092-uftc8inx 912 13 day day NN cord-010092-uftc8inx 912 14 . . . cord-010092-uftc8inx 913 1 70 70 CD cord-010092-uftc8inx 913 2 pediatric pediatric JJ cord-010092-uftc8inx 913 3 patients patient NNS cord-010092-uftc8inx 913 4 with with IN cord-010092-uftc8inx 913 5 various various JJ cord-010092-uftc8inx 913 6 oncological oncological JJ cord-010092-uftc8inx 913 7 and and CC cord-010092-uftc8inx 913 8 hematological hematological JJ cord-010092-uftc8inx 913 9 diseases disease NNS cord-010092-uftc8inx 913 10 were be VBD cord-010092-uftc8inx 913 11 randomized randomize VBN cord-010092-uftc8inx 913 12 to to IN cord-010092-uftc8inx 913 13 2 2 CD cord-010092-uftc8inx 913 14 groups group NNS cord-010092-uftc8inx 913 15 of of IN cord-010092-uftc8inx 913 16 35 35 CD cord-010092-uftc8inx 913 17 members member NNS cord-010092-uftc8inx 913 18 in in IN cord-010092-uftc8inx 913 19 each each DT cord-010092-uftc8inx 913 20 group group NN cord-010092-uftc8inx 913 21 . . . cord-010092-uftc8inx 914 1 The the DT cord-010092-uftc8inx 914 2 test test NN cord-010092-uftc8inx 914 3 group group NN cord-010092-uftc8inx 914 4 of of IN cord-010092-uftc8inx 914 5 patients patient NNS cord-010092-uftc8inx 914 6 received receive VBD cord-010092-uftc8inx 914 7 transfusions transfusion NNS cord-010092-uftc8inx 914 8 of of IN cord-010092-uftc8inx 914 9 a a DT cord-010092-uftc8inx 914 10 pathogen pathogen NN cord-010092-uftc8inx 914 11 - - HYPH cord-010092-uftc8inx 914 12 reduced reduce VBN cord-010092-uftc8inx 914 13 RBCS rbc NNS cord-010092-uftc8inx 914 14 ; ; : cord-010092-uftc8inx 914 15 the the DT cord-010092-uftc8inx 914 16 control control NN cord-010092-uftc8inx 914 17 group group NN cord-010092-uftc8inx 914 18 received receive VBD cord-010092-uftc8inx 914 19 transfusions transfusion NNS cord-010092-uftc8inx 914 20 of of IN cord-010092-uftc8inx 914 21 a a DT cord-010092-uftc8inx 914 22 gamma gamma NN cord-010092-uftc8inx 914 23 - - HYPH cord-010092-uftc8inx 914 24 irradiated irradiate VBN cord-010092-uftc8inx 914 25 RBCS rbc NNS cord-010092-uftc8inx 914 26 . . . cord-010092-uftc8inx 915 1 The the DT cord-010092-uftc8inx 915 2 next next JJ cord-010092-uftc8inx 915 3 day day NN cord-010092-uftc8inx 915 4 after after IN cord-010092-uftc8inx 915 5 transfusion transfusion NN cord-010092-uftc8inx 915 6 were be VBD cord-010092-uftc8inx 915 7 assessed assess VBN cord-010092-uftc8inx 915 8 hemoglobin hemoglobin NN cord-010092-uftc8inx 915 9 and and CC cord-010092-uftc8inx 915 10 hematocrit hematocrit NN cord-010092-uftc8inx 915 11 increment increment NN cord-010092-uftc8inx 915 12 , , , cord-010092-uftc8inx 915 13 the the DT cord-010092-uftc8inx 915 14 level level NN cord-010092-uftc8inx 915 15 of of IN cord-010092-uftc8inx 915 16 potassium potassium NN cord-010092-uftc8inx 915 17 and and CC cord-010092-uftc8inx 915 18 haptoglobin haptoglobin NN cord-010092-uftc8inx 915 19 in in IN cord-010092-uftc8inx 915 20 the the DT cord-010092-uftc8inx 915 21 patients patient NNS cord-010092-uftc8inx 915 22 ' ' POS cord-010092-uftc8inx 915 23 serum serum NN cord-010092-uftc8inx 915 24 , , , cord-010092-uftc8inx 915 25 the the DT cord-010092-uftc8inx 915 26 frequency frequency NN cord-010092-uftc8inx 915 27 and and CC cord-010092-uftc8inx 915 28 severity severity NN cord-010092-uftc8inx 915 29 of of IN cord-010092-uftc8inx 915 30 transfusion transfusion NN cord-010092-uftc8inx 915 31 reactions reaction NNS cord-010092-uftc8inx 915 32 . . . cord-010092-uftc8inx 916 1 3 3 LS cord-010092-uftc8inx 916 2 - - SYM cord-010092-uftc8inx 916 3 5 5 CD cord-010092-uftc8inx 916 4 days day NNS cord-010092-uftc8inx 916 5 after after IN cord-010092-uftc8inx 916 6 the the DT cord-010092-uftc8inx 916 7 transfusion transfusion NN cord-010092-uftc8inx 916 8 , , , cord-010092-uftc8inx 916 9 the the DT cord-010092-uftc8inx 916 10 direct direct JJ cord-010092-uftc8inx 916 11 antiglobulin antiglobulin NN cord-010092-uftc8inx 916 12 test test NN cord-010092-uftc8inx 916 13 ( ( -LRB- cord-010092-uftc8inx 916 14 DAT DAT NNP cord-010092-uftc8inx 916 15 ) ) -RRB- cord-010092-uftc8inx 916 16 was be VBD cord-010092-uftc8inx 916 17 performed perform VBN cord-010092-uftc8inx 916 18 and and CC cord-010092-uftc8inx 916 19 after after IN cord-010092-uftc8inx 916 20 14 14 CD cord-010092-uftc8inx 916 21 - - SYM cord-010092-uftc8inx 916 22 21 21 CD cord-010092-uftc8inx 916 23 days day NNS cord-010092-uftc8inx 916 24 the the DT cord-010092-uftc8inx 916 25 indirect indirect JJ cord-010092-uftc8inx 916 26 antiglobulin antiglobulin NN cord-010092-uftc8inx 916 27 test test NN cord-010092-uftc8inx 916 28 ( ( -LRB- cord-010092-uftc8inx 916 29 IAT IAT NNP cord-010092-uftc8inx 916 30 ) ) -RRB- cord-010092-uftc8inx 916 31 was be VBD cord-010092-uftc8inx 916 32 performed perform VBN cord-010092-uftc8inx 916 33 . . . cord-010092-uftc8inx 917 1 The the DT cord-010092-uftc8inx 917 2 interval interval NN cord-010092-uftc8inx 917 3 to to IN cord-010092-uftc8inx 917 4 the the DT cord-010092-uftc8inx 917 5 next next JJ cord-010092-uftc8inx 917 6 need need NN cord-010092-uftc8inx 917 7 for for IN cord-010092-uftc8inx 917 8 transfusion transfusion NN cord-010092-uftc8inx 917 9 was be VBD cord-010092-uftc8inx 917 10 also also RB cord-010092-uftc8inx 917 11 evaluated evaluate VBN cord-010092-uftc8inx 917 12 . . . cord-010092-uftc8inx 918 1 Results result NNS cord-010092-uftc8inx 918 2 : : : cord-010092-uftc8inx 919 1 The the DT cord-010092-uftc8inx 919 2 increase increase NN cord-010092-uftc8inx 919 3 in in IN cord-010092-uftc8inx 919 4 hemoglobin hemoglobin NN cord-010092-uftc8inx 919 5 and and CC cord-010092-uftc8inx 919 6 hematocrit hematocrit NN cord-010092-uftc8inx 919 7 ( ( -LRB- cord-010092-uftc8inx 919 8 P p NN cord-010092-uftc8inx 919 9 = = SYM cord-010092-uftc8inx 919 10 0.2 0.2 CD cord-010092-uftc8inx 919 11 ) ) -RRB- cord-010092-uftc8inx 919 12 , , , cord-010092-uftc8inx 919 13 as as RB cord-010092-uftc8inx 919 14 well well RB cord-010092-uftc8inx 919 15 as as IN cord-010092-uftc8inx 919 16 the the DT cord-010092-uftc8inx 919 17 concentration concentration NN cord-010092-uftc8inx 919 18 of of IN cord-010092-uftc8inx 919 19 potassium potassium NN cord-010092-uftc8inx 919 20 ( ( -LRB- cord-010092-uftc8inx 919 21 P p NN cord-010092-uftc8inx 919 22 = = SYM cord-010092-uftc8inx 919 23 0.44 0.44 CD cord-010092-uftc8inx 919 24 ) ) -RRB- cord-010092-uftc8inx 919 25 and and CC cord-010092-uftc8inx 919 26 haptoglobin haptoglobin NN cord-010092-uftc8inx 919 27 ( ( -LRB- cord-010092-uftc8inx 919 28 P p NN cord-010092-uftc8inx 919 29 = = SYM cord-010092-uftc8inx 919 30 0.25 0.25 CD cord-010092-uftc8inx 919 31 ) ) -RRB- cord-010092-uftc8inx 919 32 in in IN cord-010092-uftc8inx 919 33 the the DT cord-010092-uftc8inx 919 34 patients patient NNS cord-010092-uftc8inx 919 35 ' ' POS cord-010092-uftc8inx 919 36 serum serum NN cord-010092-uftc8inx 919 37 after after IN cord-010092-uftc8inx 919 38 the the DT cord-010092-uftc8inx 919 39 transfusion transfusion NN cord-010092-uftc8inx 919 40 did do VBD cord-010092-uftc8inx 919 41 not not RB cord-010092-uftc8inx 919 42 differ differ VB cord-010092-uftc8inx 919 43 between between IN cord-010092-uftc8inx 919 44 groups group NNS cord-010092-uftc8inx 919 45 . . . cord-010092-uftc8inx 920 1 None none NN cord-010092-uftc8inx 920 2 of of IN cord-010092-uftc8inx 920 3 the the DT cord-010092-uftc8inx 920 4 patients patient NNS cord-010092-uftc8inx 920 5 in in IN cord-010092-uftc8inx 920 6 both both DT cord-010092-uftc8inx 920 7 groups group NNS cord-010092-uftc8inx 920 8 had have VBD cord-010092-uftc8inx 920 9 hyperkalemia hyperkalemia NN cord-010092-uftc8inx 920 10 after after IN cord-010092-uftc8inx 920 11 transfusion transfusion NN cord-010092-uftc8inx 920 12 . . . cord-010092-uftc8inx 921 1 In in IN cord-010092-uftc8inx 921 2 each each DT cord-010092-uftc8inx 921 3 group group NN cord-010092-uftc8inx 921 4 , , , cord-010092-uftc8inx 921 5 two two CD cord-010092-uftc8inx 921 6 patients patient NNS cord-010092-uftc8inx 921 7 had have VBD cord-010092-uftc8inx 921 8 febrile febrile JJ cord-010092-uftc8inx 921 9 non non JJ cord-010092-uftc8inx 921 10 - - JJ cord-010092-uftc8inx 921 11 hemolytic hemolytic JJ cord-010092-uftc8inx 921 12 transfusion transfusion NN cord-010092-uftc8inx 921 13 reactions reaction NNS cord-010092-uftc8inx 921 14 of of IN cord-010092-uftc8inx 921 15 comparable comparable JJ cord-010092-uftc8inx 921 16 severity severity NN cord-010092-uftc8inx 921 17 ( ( -LRB- cord-010092-uftc8inx 921 18 P p NN cord-010092-uftc8inx 921 19 = = SYM cord-010092-uftc8inx 921 20 1 1 CD cord-010092-uftc8inx 921 21 ) ) -RRB- cord-010092-uftc8inx 921 22 . . . cord-010092-uftc8inx 922 1 All all DT cord-010092-uftc8inx 922 2 DAT DAT NNP cord-010092-uftc8inx 922 3 and and CC cord-010092-uftc8inx 922 4 IAT IAT NNP cord-010092-uftc8inx 922 5 tests test NNS cord-010092-uftc8inx 922 6 were be VBD cord-010092-uftc8inx 922 7 negative negative JJ cord-010092-uftc8inx 922 8 in in IN cord-010092-uftc8inx 922 9 both both DT cord-010092-uftc8inx 922 10 groups group NNS cord-010092-uftc8inx 922 11 . . . cord-010092-uftc8inx 923 1 The the DT cord-010092-uftc8inx 923 2 interval interval NN cord-010092-uftc8inx 923 3 between between IN cord-010092-uftc8inx 923 4 transfusions transfusion NNS cord-010092-uftc8inx 923 5 were be VBD cord-010092-uftc8inx 923 6 not not RB cord-010092-uftc8inx 923 7 significantly significantly RB cord-010092-uftc8inx 923 8 different different JJ cord-010092-uftc8inx 923 9 between between IN cord-010092-uftc8inx 923 10 groups group NNS cord-010092-uftc8inx 923 11 ( ( -LRB- cord-010092-uftc8inx 923 12 P p NN cord-010092-uftc8inx 923 13 = = SYM cord-010092-uftc8inx 923 14 0.39 0.39 CD cord-010092-uftc8inx 923 15 ) ) -RRB- cord-010092-uftc8inx 923 16 . . . cord-010092-uftc8inx 924 1 Only only RB cord-010092-uftc8inx 924 2 in in IN cord-010092-uftc8inx 924 3 the the DT cord-010092-uftc8inx 924 4 test test NN cord-010092-uftc8inx 924 5 group group NN cord-010092-uftc8inx 924 6 was be VBD cord-010092-uftc8inx 924 7 found find VBN cord-010092-uftc8inx 924 8 the the DT cord-010092-uftc8inx 924 9 correlation correlation NN cord-010092-uftc8inx 924 10 between between IN cord-010092-uftc8inx 924 11 the the DT cord-010092-uftc8inx 924 12 increase increase NN cord-010092-uftc8inx 924 13 in in IN cord-010092-uftc8inx 924 14 the the DT cord-010092-uftc8inx 924 15 hemoglobin hemoglobin NN cord-010092-uftc8inx 924 16 and and CC cord-010092-uftc8inx 924 17 hematocrit hematocrit NN cord-010092-uftc8inx 924 18 values value NNS cord-010092-uftc8inx 924 19 with with IN cord-010092-uftc8inx 924 20 the the DT cord-010092-uftc8inx 924 21 volume volume NN cord-010092-uftc8inx 924 22 of of IN cord-010092-uftc8inx 924 23 transfusion transfusion NN cord-010092-uftc8inx 924 24 , , , cord-010092-uftc8inx 924 25 with with IN cord-010092-uftc8inx 924 26 the the DT cord-010092-uftc8inx 924 27 dose dose NN cord-010092-uftc8inx 924 28 and and CC cord-010092-uftc8inx 924 29 the the DT cord-010092-uftc8inx 924 30 adjusted adjusted JJ cord-010092-uftc8inx 924 31 dose dose NN cord-010092-uftc8inx 924 32 of of IN cord-010092-uftc8inx 924 33 hemoglobin hemoglobin NN cord-010092-uftc8inx 924 34 obtained obtain VBN cord-010092-uftc8inx 924 35 for for IN cord-010092-uftc8inx 924 36 the the DT cord-010092-uftc8inx 924 37 transfusion transfusion NN cord-010092-uftc8inx 924 38 on on IN cord-010092-uftc8inx 924 39 body body NN cord-010092-uftc8inx 924 40 weight weight NN cord-010092-uftc8inx 924 41 . . . cord-010092-uftc8inx 925 1 And and CC cord-010092-uftc8inx 925 2 in in IN cord-010092-uftc8inx 925 3 this this DT cord-010092-uftc8inx 925 4 group group NN cord-010092-uftc8inx 925 5 was be VBD cord-010092-uftc8inx 925 6 found find VBN cord-010092-uftc8inx 925 7 inverse inverse JJ cord-010092-uftc8inx 925 8 correlation correlation NN cord-010092-uftc8inx 925 9 between between IN cord-010092-uftc8inx 925 10 the the DT cord-010092-uftc8inx 925 11 hemoglobin hemoglobin NN cord-010092-uftc8inx 925 12 and and CC cord-010092-uftc8inx 925 13 hematocrit hematocrit NN cord-010092-uftc8inx 925 14 increment increment NN cord-010092-uftc8inx 925 15 with with IN cord-010092-uftc8inx 925 16 the the DT cord-010092-uftc8inx 925 17 level level NN cord-010092-uftc8inx 925 18 of of IN cord-010092-uftc8inx 925 19 hemolysis hemolysis NN cord-010092-uftc8inx 925 20 in in IN cord-010092-uftc8inx 925 21 the the DT cord-010092-uftc8inx 925 22 RBCS rbc NNS cord-010092-uftc8inx 925 23 . . . cord-010092-uftc8inx 926 1 Summary Summary NNP cord-010092-uftc8inx 926 2 / / SYM cord-010092-uftc8inx 926 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 926 4 : : : cord-010092-uftc8inx 927 1 We -PRON- PRP cord-010092-uftc8inx 927 2 found find VBD cord-010092-uftc8inx 927 3 that that IN cord-010092-uftc8inx 927 4 the the DT cord-010092-uftc8inx 927 5 clinical clinical JJ cord-010092-uftc8inx 927 6 efficacy efficacy NN cord-010092-uftc8inx 927 7 and and CC cord-010092-uftc8inx 927 8 safety safety NN cord-010092-uftc8inx 927 9 of of IN cord-010092-uftc8inx 927 10 RBCS rbc NNS cord-010092-uftc8inx 927 11 of of IN cord-010092-uftc8inx 927 12 the the DT cord-010092-uftc8inx 927 13 compared compare VBN cord-010092-uftc8inx 927 14 groups group NNS cord-010092-uftc8inx 927 15 did do VBD cord-010092-uftc8inx 927 16 not not RB cord-010092-uftc8inx 927 17 differ differ VB cord-010092-uftc8inx 927 18 . . . cord-010092-uftc8inx 928 1 There there EX cord-010092-uftc8inx 928 2 was be VBD cord-010092-uftc8inx 928 3 no no DT cord-010092-uftc8inx 928 4 evidence evidence NN cord-010092-uftc8inx 928 5 of of IN cord-010092-uftc8inx 928 6 immune immune JJ cord-010092-uftc8inx 928 7 elimination elimination NN cord-010092-uftc8inx 928 8 and and CC cord-010092-uftc8inx 928 9 allo allo NN cord-010092-uftc8inx 928 10 - - HYPH cord-010092-uftc8inx 928 11 sensitization sensitization NN cord-010092-uftc8inx 928 12 caused cause VBN cord-010092-uftc8inx 928 13 by by IN cord-010092-uftc8inx 928 14 pathogen pathogen NN cord-010092-uftc8inx 928 15 - - HYPH cord-010092-uftc8inx 928 16 reduced reduce VBN cord-010092-uftc8inx 928 17 RBCS rbc NNS cord-010092-uftc8inx 928 18 . . . cord-010092-uftc8inx 929 1 According accord VBG cord-010092-uftc8inx 929 2 to to IN cord-010092-uftc8inx 929 3 our -PRON- PRP$ cord-010092-uftc8inx 929 4 data datum NNS cord-010092-uftc8inx 929 5 , , , cord-010092-uftc8inx 929 6 the the DT cord-010092-uftc8inx 929 7 spectrum spectrum NN cord-010092-uftc8inx 929 8 of of IN cord-010092-uftc8inx 929 9 efficiency efficiency NN cord-010092-uftc8inx 929 10 and and CC cord-010092-uftc8inx 929 11 safety safety NN cord-010092-uftc8inx 929 12 indicators indicator NNS cord-010092-uftc8inx 929 13 of of IN cord-010092-uftc8inx 929 14 pathogen pathogen NN cord-010092-uftc8inx 929 15 - - HYPH cord-010092-uftc8inx 929 16 reduced reduce VBN cord-010092-uftc8inx 929 17 RBCS rbc NNS cord-010092-uftc8inx 929 18 is be VBZ cord-010092-uftc8inx 929 19 no no DT cord-010092-uftc8inx 929 20 worse bad JJR cord-010092-uftc8inx 929 21 than than IN cord-010092-uftc8inx 929 22 that that DT cord-010092-uftc8inx 929 23 of of IN cord-010092-uftc8inx 929 24 gamma gamma NN cord-010092-uftc8inx 929 25 - - HYPH cord-010092-uftc8inx 929 26 irradiated irradiate VBN cord-010092-uftc8inx 929 27 RBCS RBCS NNP cord-010092-uftc8inx 929 28 , , , cord-010092-uftc8inx 929 29 provided provide VBN cord-010092-uftc8inx 929 30 that that IN cord-010092-uftc8inx 929 31 RBCS RBCS NNP cord-010092-uftc8inx 929 32 is be VBZ cord-010092-uftc8inx 929 33 used use VBN cord-010092-uftc8inx 929 34 for for IN cord-010092-uftc8inx 929 35 14 14 CD cord-010092-uftc8inx 929 36 days day NNS cord-010092-uftc8inx 929 37 of of IN cord-010092-uftc8inx 929 38 storage storage NN cord-010092-uftc8inx 929 39 . . . cord-010092-uftc8inx 930 1 The the DT cord-010092-uftc8inx 930 2 founded found VBN cord-010092-uftc8inx 930 3 correlation correlation NN cord-010092-uftc8inx 930 4 suggests suggest VBZ cord-010092-uftc8inx 930 5 that that IN cord-010092-uftc8inx 930 6 the the DT cord-010092-uftc8inx 930 7 efficiency efficiency NN cord-010092-uftc8inx 930 8 of of IN cord-010092-uftc8inx 930 9 pathogen pathogen NN cord-010092-uftc8inx 930 10 - - HYPH cord-010092-uftc8inx 930 11 reduced reduce VBN cord-010092-uftc8inx 930 12 RBCS RBCS NNP cord-010092-uftc8inx 930 13 transfusions transfusion NNS cord-010092-uftc8inx 930 14 is be VBZ cord-010092-uftc8inx 930 15 more more RBR cord-010092-uftc8inx 930 16 dependent dependent JJ cord-010092-uftc8inx 930 17 on on IN cord-010092-uftc8inx 930 18 the the DT cord-010092-uftc8inx 930 19 characteristics characteristic NNS cord-010092-uftc8inx 930 20 of of IN cord-010092-uftc8inx 930 21 the the DT cord-010092-uftc8inx 930 22 RBCS rbc NNS cord-010092-uftc8inx 930 23 . . . cord-010092-uftc8inx 931 1 Background background NN cord-010092-uftc8inx 931 2 : : : cord-010092-uftc8inx 932 1 Patient patient JJ cord-010092-uftc8inx 932 2 blood blood NN cord-010092-uftc8inx 932 3 management management NN cord-010092-uftc8inx 932 4 ( ( -LRB- cord-010092-uftc8inx 932 5 PBM PBM NNP cord-010092-uftc8inx 932 6 ) ) -RRB- cord-010092-uftc8inx 932 7 programs program NNS cord-010092-uftc8inx 932 8 are be VBP cord-010092-uftc8inx 932 9 expanding expand VBG cord-010092-uftc8inx 932 10 at at IN cord-010092-uftc8inx 932 11 an an DT cord-010092-uftc8inx 932 12 international international JJ cord-010092-uftc8inx 932 13 level level NN cord-010092-uftc8inx 932 14 . . . cord-010092-uftc8inx 933 1 A a DT cord-010092-uftc8inx 933 2 recent recent JJ cord-010092-uftc8inx 933 3 nationally nationally RB cord-010092-uftc8inx 933 4 representative representative JJ cord-010092-uftc8inx 933 5 study study NN cord-010092-uftc8inx 933 6 from from IN cord-010092-uftc8inx 933 7 United United NNP cord-010092-uftc8inx 933 8 States States NNP cord-010092-uftc8inx 933 9 observed observe VBD cord-010092-uftc8inx 933 10 pediatric pediatric JJ cord-010092-uftc8inx 933 11 age age NN cord-010092-uftc8inx 933 12 group group NN cord-010092-uftc8inx 933 13 as as IN cord-010092-uftc8inx 933 14 the the DT cord-010092-uftc8inx 933 15 only only JJ cord-010092-uftc8inx 933 16 age age NN cord-010092-uftc8inx 933 17 group group NN cord-010092-uftc8inx 933 18 showing show VBG cord-010092-uftc8inx 933 19 lack lack NN cord-010092-uftc8inx 933 20 of of IN cord-010092-uftc8inx 933 21 objective objective JJ cord-010092-uftc8inx 933 22 evidence evidence NN cord-010092-uftc8inx 933 23 of of IN cord-010092-uftc8inx 933 24 PBM PBM NNP cord-010092-uftc8inx 933 25 initiatives initiative NNS cord-010092-uftc8inx 933 26 ( ( -LRB- cord-010092-uftc8inx 933 27 Goel Goel NNP cord-010092-uftc8inx 933 28 et et FW cord-010092-uftc8inx 933 29 al al NNP cord-010092-uftc8inx 933 30 , , , cord-010092-uftc8inx 933 31 JAMA JAMA NNP cord-010092-uftc8inx 933 32 2018 2018 CD cord-010092-uftc8inx 933 33 ) ) -RRB- cord-010092-uftc8inx 933 34 . . . cord-010092-uftc8inx 934 1 Aims aim VBZ cord-010092-uftc8inx 934 2 : : : cord-010092-uftc8inx 935 1 This this DT cord-010092-uftc8inx 935 2 study study NN cord-010092-uftc8inx 935 3 aims aim VBZ cord-010092-uftc8inx 935 4 to to TO cord-010092-uftc8inx 935 5 identify identify VB cord-010092-uftc8inx 935 6 trends trend NNS cord-010092-uftc8inx 935 7 in in IN cord-010092-uftc8inx 935 8 peri peri JJ cord-010092-uftc8inx 935 9 - - HYPH cord-010092-uftc8inx 935 10 operative operative JJ cord-010092-uftc8inx 935 11 blood blood NN cord-010092-uftc8inx 935 12 utilization utilization NN cord-010092-uftc8inx 935 13 in in IN cord-010092-uftc8inx 935 14 children child NNS cord-010092-uftc8inx 935 15 undergoing undergo VBG cord-010092-uftc8inx 935 16 elective elective JJ cord-010092-uftc8inx 935 17 and and CC cord-010092-uftc8inx 935 18 non non JJ cord-010092-uftc8inx 935 19 - - JJ cord-010092-uftc8inx 935 20 elective elective JJ cord-010092-uftc8inx 935 21 surgeries surgery NNS cord-010092-uftc8inx 935 22 over over IN cord-010092-uftc8inx 935 23 5 5 CD cord-010092-uftc8inx 935 24 years year NNS cord-010092-uftc8inx 935 25 duration duration NN cord-010092-uftc8inx 935 26 from from IN cord-010092-uftc8inx 935 27 2012 2012 CD cord-010092-uftc8inx 935 28 to to IN cord-010092-uftc8inx 935 29 2016 2016 CD cord-010092-uftc8inx 935 30 . . . cord-010092-uftc8inx 936 1 Methods method NNS cord-010092-uftc8inx 936 2 : : : cord-010092-uftc8inx 936 3 Using use VBG cord-010092-uftc8inx 936 4 5 5 CD cord-010092-uftc8inx 936 5 years year NNS cord-010092-uftc8inx 936 6 data datum NNS cord-010092-uftc8inx 936 7 ( ( -LRB- cord-010092-uftc8inx 936 8 2012 2012 CD cord-010092-uftc8inx 936 9 ) ) -RRB- cord-010092-uftc8inx 936 10 ( ( -LRB- cord-010092-uftc8inx 936 11 2013 2013 CD cord-010092-uftc8inx 936 12 ) ) -RRB- cord-010092-uftc8inx 937 1 ( ( -LRB- cord-010092-uftc8inx 937 2 2014 2014 CD cord-010092-uftc8inx 937 3 ) ) -RRB- cord-010092-uftc8inx 937 4 ( ( -LRB- cord-010092-uftc8inx 937 5 2015 2015 CD cord-010092-uftc8inx 937 6 ) ) -RRB- cord-010092-uftc8inx 937 7 ( ( -LRB- cord-010092-uftc8inx 937 8 2016 2016 CD cord-010092-uftc8inx 937 9 ) ) -RRB- cord-010092-uftc8inx 938 1 Perioperative perioperative JJ cord-010092-uftc8inx 938 2 transfusions transfusion NNS cord-010092-uftc8inx 938 3 decreased decrease VBD cord-010092-uftc8inx 938 4 steadily steadily RB cord-010092-uftc8inx 938 5 per per IN cord-010092-uftc8inx 938 6 year year NN cord-010092-uftc8inx 938 7 from from IN cord-010092-uftc8inx 938 8 6.4 6.4 CD cord-010092-uftc8inx 938 9 % % NN cord-010092-uftc8inx 938 10 in in IN cord-010092-uftc8inx 938 11 2012 2012 CD cord-010092-uftc8inx 938 12 to to IN cord-010092-uftc8inx 938 13 5.5 5.5 CD cord-010092-uftc8inx 938 14 % % NN cord-010092-uftc8inx 938 15 ( ( -LRB- cord-010092-uftc8inx 938 16 14 14 CD cord-010092-uftc8inx 938 17 % % NN cord-010092-uftc8inx 938 18 cumulative cumulative JJ cord-010092-uftc8inx 938 19 decline decline NN cord-010092-uftc8inx 938 20 ) ) -RRB- cord-010092-uftc8inx 938 21 in in IN cord-010092-uftc8inx 938 22 2016 2016 CD cord-010092-uftc8inx 938 23 for for IN cord-010092-uftc8inx 938 24 children child NNS cord-010092-uftc8inx 938 25 of of IN cord-010092-uftc8inx 938 26 all all DT cord-010092-uftc8inx 938 27 ages age NNS cord-010092-uftc8inx 938 28 ( ( -LRB- cord-010092-uftc8inx 938 29 OR or CC cord-010092-uftc8inx 938 30 0.966 0.966 CD cord-010092-uftc8inx 938 31 ; ; : cord-010092-uftc8inx 938 32 95 95 CD cord-010092-uftc8inx 938 33 % % NN cord-010092-uftc8inx 938 34 CI CI NNP cord-010092-uftc8inx 938 35 0.957 0.957 CD cord-010092-uftc8inx 938 36 - - HYPH cord-010092-uftc8inx 938 37 0.976 0.976 CD cord-010092-uftc8inx 938 38 ; ; : cord-010092-uftc8inx 938 39 p p NN cord-010092-uftc8inx 938 40 trend trend NN cord-010092-uftc8inx 938 41 < < XX cord-010092-uftc8inx 938 42 0.001 0.001 CD cord-010092-uftc8inx 938 43 ) ) -RRB- cord-010092-uftc8inx 938 44 . . . cord-010092-uftc8inx 939 1 The the DT cord-010092-uftc8inx 939 2 cumulative cumulative JJ cord-010092-uftc8inx 939 3 change change NN cord-010092-uftc8inx 939 4 in in IN cord-010092-uftc8inx 939 5 elective elective JJ cord-010092-uftc8inx 939 6 procedures procedure NNS cord-010092-uftc8inx 939 7 was be VBD cord-010092-uftc8inx 939 8 9.2 9.2 CD cord-010092-uftc8inx 939 9 % % NN cord-010092-uftc8inx 939 10 versus versus IN cord-010092-uftc8inx 939 11 27.2 27.2 CD cord-010092-uftc8inx 939 12 % % NN cord-010092-uftc8inx 939 13 decrease decrease NN cord-010092-uftc8inx 939 14 in in IN cord-010092-uftc8inx 939 15 urgent urgent JJ cord-010092-uftc8inx 939 16 / / SYM cord-010092-uftc8inx 939 17 emergent emergent JJ cord-010092-uftc8inx 939 18 procedures procedure NNS cord-010092-uftc8inx 939 19 ( ( -LRB- cord-010092-uftc8inx 939 20 p p NN cord-010092-uftc8inx 939 21 trend trend NN cord-010092-uftc8inx 939 22 < < XX cord-010092-uftc8inx 939 23 0.001 0.001 CD cord-010092-uftc8inx 939 24 ) ) -RRB- cord-010092-uftc8inx 939 25 . . . cord-010092-uftc8inx 940 1 Summary Summary NNP cord-010092-uftc8inx 940 2 / / SYM cord-010092-uftc8inx 940 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 940 4 : : : cord-010092-uftc8inx 941 1 In in IN cord-010092-uftc8inx 941 2 this this DT cord-010092-uftc8inx 941 3 large large JJ cord-010092-uftc8inx 941 4 prospective prospective JJ cord-010092-uftc8inx 941 5 registry registry NN cord-010092-uftc8inx 941 6 study study NN cord-010092-uftc8inx 941 7 of of IN cord-010092-uftc8inx 941 8 > > $ cord-010092-uftc8inx 941 9 350,000 350,000 CD cord-010092-uftc8inx 941 10 children child NNS cord-010092-uftc8inx 941 11 undergoing undergo VBG cord-010092-uftc8inx 941 12 elective elective JJ cord-010092-uftc8inx 941 13 / / SYM cord-010092-uftc8inx 941 14 non non JJ cord-010092-uftc8inx 941 15 - - JJ cord-010092-uftc8inx 941 16 elective elective JJ cord-010092-uftc8inx 941 17 surgeries surgery NNS cord-010092-uftc8inx 941 18 , , , cord-010092-uftc8inx 941 19 a a DT cord-010092-uftc8inx 941 20 statistically statistically RB cord-010092-uftc8inx 941 21 significant significant JJ cord-010092-uftc8inx 941 22 decrease decrease NN cord-010092-uftc8inx 941 23 in in IN cord-010092-uftc8inx 941 24 utilization utilization NN cord-010092-uftc8inx 941 25 of of IN cord-010092-uftc8inx 941 26 peri peri JJ cord-010092-uftc8inx 941 27 - - HYPH cord-010092-uftc8inx 941 28 operative operative JJ cord-010092-uftc8inx 941 29 RBC RBC NNP cord-010092-uftc8inx 941 30 transfusions transfusion NNS cord-010092-uftc8inx 941 31 was be VBD cord-010092-uftc8inx 941 32 seen see VBN cord-010092-uftc8inx 941 33 across across IN cord-010092-uftc8inx 941 34 5 5 CD cord-010092-uftc8inx 941 35 years year NNS cord-010092-uftc8inx 941 36 from from IN cord-010092-uftc8inx 941 37 2012 2012 CD cord-010092-uftc8inx 941 38 through through IN cord-010092-uftc8inx 941 39 2016 2016 CD cord-010092-uftc8inx 941 40 with with IN cord-010092-uftc8inx 941 41 more more RBR cord-010092-uftc8inx 941 42 significant significant JJ cord-010092-uftc8inx 941 43 decrease decrease NN cord-010092-uftc8inx 941 44 in in IN cord-010092-uftc8inx 941 45 urgent urgent JJ cord-010092-uftc8inx 941 46 / / SYM cord-010092-uftc8inx 941 47 emergent emergent JJ cord-010092-uftc8inx 941 48 procedures procedure NNS cord-010092-uftc8inx 941 49 than than IN cord-010092-uftc8inx 941 50 elective elective JJ cord-010092-uftc8inx 941 51 procedures procedure NNS cord-010092-uftc8inx 941 52 While while IN cord-010092-uftc8inx 941 53 these these DT cord-010092-uftc8inx 941 54 findings finding NNS cord-010092-uftc8inx 941 55 need need VBP cord-010092-uftc8inx 941 56 evaluation evaluation NN cord-010092-uftc8inx 941 57 for for IN cord-010092-uftc8inx 941 58 non non JJ cord-010092-uftc8inx 941 59 - - JJ cord-010092-uftc8inx 941 60 surgical surgical JJ cord-010092-uftc8inx 941 61 indications indication NNS cord-010092-uftc8inx 941 62 of of IN cord-010092-uftc8inx 941 63 transfusion transfusion NN cord-010092-uftc8inx 941 64 , , , cord-010092-uftc8inx 941 65 these these DT cord-010092-uftc8inx 941 66 results result NNS cord-010092-uftc8inx 941 67 may may MD cord-010092-uftc8inx 941 68 provide provide VB cord-010092-uftc8inx 941 69 first first JJ cord-010092-uftc8inx 941 70 evidence evidence NN cord-010092-uftc8inx 941 71 of of IN cord-010092-uftc8inx 941 72 peri peri JJ cord-010092-uftc8inx 941 73 - - HYPH cord-010092-uftc8inx 941 74 operative operative JJ cord-010092-uftc8inx 941 75 pediatric pediatric JJ cord-010092-uftc8inx 941 76 patient patient NN cord-010092-uftc8inx 941 77 blood blood NN cord-010092-uftc8inx 941 78 management management NN cord-010092-uftc8inx 941 79 strategies strategy NNS cord-010092-uftc8inx 941 80 being be VBG cord-010092-uftc8inx 941 81 implemented implement VBN cord-010092-uftc8inx 941 82 to to TO cord-010092-uftc8inx 941 83 optimize optimize VB cord-010092-uftc8inx 941 84 transfusions transfusion NNS cord-010092-uftc8inx 941 85 in in IN cord-010092-uftc8inx 941 86 pediatric pediatric JJ cord-010092-uftc8inx 941 87 population population NN cord-010092-uftc8inx 941 88 . . . cord-010092-uftc8inx 942 1 Adverse adverse JJ cord-010092-uftc8inx 942 2 Events event NNS cord-010092-uftc8inx 942 3 -TTI -TTI : cord-010092-uftc8inx 942 4 , , , cord-010092-uftc8inx 942 5 Immune Immune NNP cord-010092-uftc8inx 942 6 Interactions Interactions NNPS cord-010092-uftc8inx 942 7 and and CC cord-010092-uftc8inx 942 8 Risk Risk NNP cord-010092-uftc8inx 942 9 3C 3c NN cord-010092-uftc8inx 942 10 - - HYPH cord-010092-uftc8inx 942 11 S08 S08 NNP cord-010092-uftc8inx 942 12 - - HYPH cord-010092-uftc8inx 942 13 01 01 CD cord-010092-uftc8inx 942 14 Transfusion Transfusion NNP cord-010092-uftc8inx 942 15 - - HYPH cord-010092-uftc8inx 942 16 transmitted transmit VBN cord-010092-uftc8inx 942 17 infections infection NNS cord-010092-uftc8inx 942 18 ( ( -LRB- cord-010092-uftc8inx 942 19 TTI TTI NNP cord-010092-uftc8inx 942 20 ) ) -RRB- cord-010092-uftc8inx 942 21 are be VBP cord-010092-uftc8inx 942 22 a a DT cord-010092-uftc8inx 942 23 long long RB cord-010092-uftc8inx 942 24 - - HYPH cord-010092-uftc8inx 942 25 standing standing NN cord-010092-uftc8inx 942 26 and and CC cord-010092-uftc8inx 942 27 well well RB cord-010092-uftc8inx 942 28 recognized recognize VBN cord-010092-uftc8inx 942 29 concern concern NN cord-010092-uftc8inx 942 30 in in IN cord-010092-uftc8inx 942 31 medicine medicine NN cord-010092-uftc8inx 942 32 , , , cord-010092-uftc8inx 942 33 which which WDT cord-010092-uftc8inx 942 34 is be VBZ cord-010092-uftc8inx 942 35 tackled tackle VBN cord-010092-uftc8inx 942 36 on on IN cord-010092-uftc8inx 942 37 the the DT cord-010092-uftc8inx 942 38 highest high JJS cord-010092-uftc8inx 942 39 level level NN cord-010092-uftc8inx 942 40 to to TO cord-010092-uftc8inx 942 41 guarantee guarantee VB cord-010092-uftc8inx 942 42 the the DT cord-010092-uftc8inx 942 43 safety safety NN cord-010092-uftc8inx 942 44 of of IN cord-010092-uftc8inx 942 45 the the DT cord-010092-uftc8inx 942 46 transfusion transfusion NN cord-010092-uftc8inx 942 47 procedure procedure NN cord-010092-uftc8inx 942 48 for for IN cord-010092-uftc8inx 942 49 all all DT cord-010092-uftc8inx 942 50 stake stake NN cord-010092-uftc8inx 942 51 holders holder NNS cord-010092-uftc8inx 942 52 . . . cord-010092-uftc8inx 943 1 These these DT cord-010092-uftc8inx 943 2 include include VBP cord-010092-uftc8inx 943 3 the the DT cord-010092-uftc8inx 943 4 recipient recipient NN cord-010092-uftc8inx 943 5 patients patient NNS cord-010092-uftc8inx 943 6 , , , cord-010092-uftc8inx 943 7 the the DT cord-010092-uftc8inx 943 8 donating donate VBG cord-010092-uftc8inx 943 9 volunteers volunteer NNS cord-010092-uftc8inx 943 10 , , , cord-010092-uftc8inx 943 11 the the DT cord-010092-uftc8inx 943 12 health health NN cord-010092-uftc8inx 943 13 care care NN cord-010092-uftc8inx 943 14 workers worker NNS cord-010092-uftc8inx 943 15 involved involve VBN cord-010092-uftc8inx 943 16 , , , cord-010092-uftc8inx 943 17 and and CC cord-010092-uftc8inx 943 18 their -PRON- PRP$ cord-010092-uftc8inx 943 19 respective respective JJ cord-010092-uftc8inx 943 20 contact contact NN cord-010092-uftc8inx 943 21 persons person NNS cord-010092-uftc8inx 943 22 . . . cord-010092-uftc8inx 944 1 Accordingly accordingly RB cord-010092-uftc8inx 944 2 , , , cord-010092-uftc8inx 944 3 current current JJ cord-010092-uftc8inx 944 4 national national JJ cord-010092-uftc8inx 944 5 and and CC cord-010092-uftc8inx 944 6 international international JJ cord-010092-uftc8inx 944 7 guidelines guideline NNS cord-010092-uftc8inx 944 8 including include VBG cord-010092-uftc8inx 944 9 expert expert NN cord-010092-uftc8inx 944 10 societies society NNS cord-010092-uftc8inx 944 11 and and CC cord-010092-uftc8inx 944 12 the the DT cord-010092-uftc8inx 944 13 WHO who WP cord-010092-uftc8inx 944 14 provide provide VBP cord-010092-uftc8inx 944 15 medical medical JJ cord-010092-uftc8inx 944 16 , , , cord-010092-uftc8inx 944 17 technical technical JJ cord-010092-uftc8inx 944 18 , , , cord-010092-uftc8inx 944 19 and and CC cord-010092-uftc8inx 944 20 legal legal JJ cord-010092-uftc8inx 944 21 frameworks framework NNS cord-010092-uftc8inx 944 22 , , , cord-010092-uftc8inx 944 23 which which WDT cord-010092-uftc8inx 944 24 are be VBP cord-010092-uftc8inx 944 25 the the DT cord-010092-uftc8inx 944 26 basis basis NN cord-010092-uftc8inx 944 27 for for IN cord-010092-uftc8inx 944 28 the the DT cord-010092-uftc8inx 944 29 standard standard JJ cord-010092-uftc8inx 944 30 operating operating NN cord-010092-uftc8inx 944 31 procedures procedure NNS cord-010092-uftc8inx 944 32 . . . cord-010092-uftc8inx 945 1 Nevertheless nevertheless RB cord-010092-uftc8inx 945 2 , , , cord-010092-uftc8inx 945 3 there there EX cord-010092-uftc8inx 945 4 are be VBP cord-010092-uftc8inx 945 5 important important JJ cord-010092-uftc8inx 945 6 challenges challenge NNS cord-010092-uftc8inx 945 7 , , , cord-010092-uftc8inx 945 8 which which WDT cord-010092-uftc8inx 945 9 render render VBP cord-010092-uftc8inx 945 10 TTI TTI NNP cord-010092-uftc8inx 945 11 a a DT cord-010092-uftc8inx 945 12 " " `` cord-010092-uftc8inx 945 13 moving move VBG cord-010092-uftc8inx 945 14 target target NN cord-010092-uftc8inx 945 15 " " '' cord-010092-uftc8inx 945 16 , , , cord-010092-uftc8inx 945 17 and and CC cord-010092-uftc8inx 945 18 reflect reflect VB cord-010092-uftc8inx 945 19 the the DT cord-010092-uftc8inx 945 20 dynamics dynamic NNS cord-010092-uftc8inx 945 21 in in IN cord-010092-uftc8inx 945 22 three three CD cord-010092-uftc8inx 945 23 main main JJ cord-010092-uftc8inx 945 24 areas area NNS cord-010092-uftc8inx 945 25 . . . cord-010092-uftc8inx 946 1 First first RB cord-010092-uftc8inx 946 2 , , , cord-010092-uftc8inx 946 3 a a DT cord-010092-uftc8inx 946 4 change change NN cord-010092-uftc8inx 946 5 in in IN cord-010092-uftc8inx 946 6 the the DT cord-010092-uftc8inx 946 7 type type NN cord-010092-uftc8inx 946 8 and and CC cord-010092-uftc8inx 946 9 number number NN cord-010092-uftc8inx 946 10 of of IN cord-010092-uftc8inx 946 11 recipient recipient NN cord-010092-uftc8inx 946 12 patients patient NNS cord-010092-uftc8inx 946 13 with with IN cord-010092-uftc8inx 946 14 past past JJ cord-010092-uftc8inx 946 15 or or CC cord-010092-uftc8inx 946 16 ongoing ongoing JJ cord-010092-uftc8inx 946 17 immunomodulatory immunomodulatory JJ cord-010092-uftc8inx 946 18 / / SYM cord-010092-uftc8inx 946 19 immunodeficiency immunodeficiency NN cord-010092-uftc8inx 946 20 component component NN cord-010092-uftc8inx 946 21 ( ( -LRB- cord-010092-uftc8inx 946 22 examples example NNS cord-010092-uftc8inx 946 23 being be VBG cord-010092-uftc8inx 946 24 HIV HIV NNP cord-010092-uftc8inx 946 25 / / SYM cord-010092-uftc8inx 946 26 AIDS AIDS NNP cord-010092-uftc8inx 946 27 , , , cord-010092-uftc8inx 946 28 SOT SOT NNP cord-010092-uftc8inx 946 29 , , , cord-010092-uftc8inx 946 30 allogenic allogenic JJ cord-010092-uftc8inx 946 31 HCT hct NN cord-010092-uftc8inx 946 32 , , , cord-010092-uftc8inx 946 33 monoclonal monoclonal JJ cord-010092-uftc8inx 946 34 antibody antibody NN cord-010092-uftc8inx 946 35 therapies therapy NNS cord-010092-uftc8inx 946 36 , , , cord-010092-uftc8inx 946 37 small small JJ cord-010092-uftc8inx 946 38 molecule molecule NN cord-010092-uftc8inx 946 39 inhibitors inhibitor NNS cord-010092-uftc8inx 946 40 ) ) -RRB- cord-010092-uftc8inx 946 41 . . . cord-010092-uftc8inx 947 1 Second second RB cord-010092-uftc8inx 947 2 , , , cord-010092-uftc8inx 947 3 changing change VBG cord-010092-uftc8inx 947 4 exposure exposure NN cord-010092-uftc8inx 947 5 to to IN cord-010092-uftc8inx 947 6 known know VBN cord-010092-uftc8inx 947 7 agents agent NNS cord-010092-uftc8inx 947 8 in in IN cord-010092-uftc8inx 947 9 donors donor NNS cord-010092-uftc8inx 947 10 due due JJ cord-010092-uftc8inx 947 11 to to IN cord-010092-uftc8inx 947 12 global global JJ cord-010092-uftc8inx 947 13 travel travel NN cord-010092-uftc8inx 947 14 , , , cord-010092-uftc8inx 947 15 migration migration NN cord-010092-uftc8inx 947 16 and and CC cord-010092-uftc8inx 947 17 displacement displacement NN cord-010092-uftc8inx 947 18 , , , cord-010092-uftc8inx 947 19 as as RB cord-010092-uftc8inx 947 20 well well RB cord-010092-uftc8inx 947 21 as as IN cord-010092-uftc8inx 947 22 environmental environmental JJ cord-010092-uftc8inx 947 23 / / SYM cord-010092-uftc8inx 947 24 climate climate NN cord-010092-uftc8inx 947 25 change change NN cord-010092-uftc8inx 947 26 . . . cord-010092-uftc8inx 948 1 Third third JJ cord-010092-uftc8inx 948 2 , , , cord-010092-uftc8inx 948 3 discovery discovery NN cord-010092-uftc8inx 948 4 and and CC cord-010092-uftc8inx 948 5 diagnostics diagnostic NNS cord-010092-uftc8inx 948 6 of of IN cord-010092-uftc8inx 948 7 old old JJ cord-010092-uftc8inx 948 8 and and CC cord-010092-uftc8inx 948 9 new new JJ cord-010092-uftc8inx 948 10 agents agent NNS cord-010092-uftc8inx 948 11 with with IN cord-010092-uftc8inx 948 12 their -PRON- PRP$ cord-010092-uftc8inx 948 13 known know VBN cord-010092-uftc8inx 948 14 or or CC cord-010092-uftc8inx 948 15 presumed presume VBN cord-010092-uftc8inx 948 16 impact impact NN cord-010092-uftc8inx 948 17 as as IN cord-010092-uftc8inx 948 18 TTI TTI NNP cord-010092-uftc8inx 948 19 . . . cord-010092-uftc8inx 949 1 These these DT cord-010092-uftc8inx 949 2 aspects aspect NNS cord-010092-uftc8inx 949 3 will will MD cord-010092-uftc8inx 949 4 require require VB cord-010092-uftc8inx 949 5 careful careful JJ cord-010092-uftc8inx 949 6 review review NN cord-010092-uftc8inx 949 7 of of IN cord-010092-uftc8inx 949 8 data datum NNS cord-010092-uftc8inx 949 9 and and CC cord-010092-uftc8inx 949 10 studies study NNS cord-010092-uftc8inx 949 11 , , , cord-010092-uftc8inx 949 12 and and CC cord-010092-uftc8inx 949 13 judicious judicious JJ cord-010092-uftc8inx 949 14 discussion discussion NN cord-010092-uftc8inx 949 15 of of IN cord-010092-uftc8inx 949 16 the the DT cord-010092-uftc8inx 949 17 potential potential JJ cord-010092-uftc8inx 949 18 action action NN cord-010092-uftc8inx 949 19 such such JJ cord-010092-uftc8inx 949 20 as as IN cord-010092-uftc8inx 949 21 selection selection NN cord-010092-uftc8inx 949 22 versus versus IN cord-010092-uftc8inx 949 23 close close JJ cord-010092-uftc8inx 949 24 monitoring monitoring NN cord-010092-uftc8inx 949 25 to to TO cord-010092-uftc8inx 949 26 keep keep VB cord-010092-uftc8inx 949 27 TTI TTI NNP cord-010092-uftc8inx 949 28 rates rate NNS cord-010092-uftc8inx 949 29 as as RB cord-010092-uftc8inx 949 30 low low JJ cord-010092-uftc8inx 949 31 as as IN cord-010092-uftc8inx 949 32 possible possible JJ cord-010092-uftc8inx 949 33 , , , cord-010092-uftc8inx 949 34 to to TO cord-010092-uftc8inx 949 35 deliver deliver VB cord-010092-uftc8inx 949 36 maximal maximal JJ cord-010092-uftc8inx 949 37 safety safety NN cord-010092-uftc8inx 949 38 of of IN cord-010092-uftc8inx 949 39 patients patient NNS cord-010092-uftc8inx 949 40 and and CC cord-010092-uftc8inx 949 41 stakeholders stakeholder NNS cord-010092-uftc8inx 949 42 . . . cord-010092-uftc8inx 950 1 Background background NN cord-010092-uftc8inx 950 2 : : : cord-010092-uftc8inx 951 1 The the DT cord-010092-uftc8inx 951 2 implementation implementation NN cord-010092-uftc8inx 951 3 of of IN cord-010092-uftc8inx 951 4 nucleic nucleic JJ cord-010092-uftc8inx 951 5 acid acid NN cord-010092-uftc8inx 951 6 testing testing NN cord-010092-uftc8inx 951 7 ( ( -LRB- cord-010092-uftc8inx 951 8 NAT NAT NNP cord-010092-uftc8inx 951 9 ) ) -RRB- cord-010092-uftc8inx 951 10 and and CC cord-010092-uftc8inx 951 11 the the DT cord-010092-uftc8inx 951 12 development development NN cord-010092-uftc8inx 951 13 of of IN cord-010092-uftc8inx 951 14 sensitive sensitive JJ cord-010092-uftc8inx 951 15 and and CC cord-010092-uftc8inx 951 16 specific specific JJ cord-010092-uftc8inx 951 17 serologic serologic JJ cord-010092-uftc8inx 951 18 assays assay NNS cord-010092-uftc8inx 951 19 to to TO cord-010092-uftc8inx 951 20 detect detect VB cord-010092-uftc8inx 951 21 HBsAg HBsAg NNP cord-010092-uftc8inx 951 22 and and CC cord-010092-uftc8inx 951 23 anti anti JJ cord-010092-uftc8inx 951 24 - - JJ cord-010092-uftc8inx 951 25 HBc hbc JJ cord-010092-uftc8inx 951 26 antibodies antibody NNS cord-010092-uftc8inx 951 27 significantly significantly RB cord-010092-uftc8inx 951 28 reduced reduce VBD cord-010092-uftc8inx 951 29 the the DT cord-010092-uftc8inx 951 30 risk risk NN cord-010092-uftc8inx 951 31 of of IN cord-010092-uftc8inx 951 32 HBV HBV NNP cord-010092-uftc8inx 951 33 transfusion transfusion NN cord-010092-uftc8inx 951 34 - - HYPH cord-010092-uftc8inx 951 35 transmission transmission NN cord-010092-uftc8inx 951 36 . . . cord-010092-uftc8inx 952 1 The the DT cord-010092-uftc8inx 952 2 apparent apparent JJ cord-010092-uftc8inx 952 3 redundant redundant JJ cord-010092-uftc8inx 952 4 testing testing NN cord-010092-uftc8inx 952 5 for for IN cord-010092-uftc8inx 952 6 two two CD cord-010092-uftc8inx 952 7 direct direct JJ cord-010092-uftc8inx 952 8 viral viral JJ cord-010092-uftc8inx 952 9 markers marker NNS cord-010092-uftc8inx 952 10 prompted prompt VBD cord-010092-uftc8inx 952 11 debates debate NNS cord-010092-uftc8inx 952 12 on on IN cord-010092-uftc8inx 952 13 maintaining maintain VBG cord-010092-uftc8inx 952 14 HBsAg hbsag ADD cord-010092-uftc8inx 952 15 screening screening NN cord-010092-uftc8inx 952 16 , , , cord-010092-uftc8inx 952 17 particularly particularly RB cord-010092-uftc8inx 952 18 in in IN cord-010092-uftc8inx 952 19 low low JJ cord-010092-uftc8inx 952 20 endemic endemic JJ cord-010092-uftc8inx 952 21 countries country NNS cord-010092-uftc8inx 952 22 where where WRB cord-010092-uftc8inx 952 23 blood blood NN cord-010092-uftc8inx 952 24 donations donation NNS cord-010092-uftc8inx 952 25 are be VBP cord-010092-uftc8inx 952 26 screened screen VBN cord-010092-uftc8inx 952 27 for for IN cord-010092-uftc8inx 952 28 anti anti JJ cord-010092-uftc8inx 952 29 - - JJ cord-010092-uftc8inx 952 30 HBc HBc NNS cord-010092-uftc8inx 952 31 . . . cord-010092-uftc8inx 953 1 However however RB cord-010092-uftc8inx 953 2 , , , cord-010092-uftc8inx 953 3 frequencies frequency NNS cord-010092-uftc8inx 953 4 of of IN cord-010092-uftc8inx 953 5 2 2 CD cord-010092-uftc8inx 953 6 - - SYM cord-010092-uftc8inx 953 7 20 20 CD cord-010092-uftc8inx 953 8 % % NN cord-010092-uftc8inx 953 9 of of IN cord-010092-uftc8inx 953 10 HBsAg HBsAg NNP cord-010092-uftc8inx 953 11 - - HYPH cord-010092-uftc8inx 953 12 confirmed confirm VBN cord-010092-uftc8inx 953 13 positive positive JJ cord-010092-uftc8inx 953 14 / / SYM cord-010092-uftc8inx 953 15 NAT NAT NNP cord-010092-uftc8inx 953 16 negative negative JJ cord-010092-uftc8inx 953 17 donations donation NNS cord-010092-uftc8inx 953 18 have have VBP cord-010092-uftc8inx 953 19 been be VBN cord-010092-uftc8inx 953 20 reported report VBN cord-010092-uftc8inx 953 21 depending depend VBG cord-010092-uftc8inx 953 22 on on IN cord-010092-uftc8inx 953 23 the the DT cord-010092-uftc8inx 953 24 sensitivity sensitivity NN cord-010092-uftc8inx 953 25 limit limit NN cord-010092-uftc8inx 953 26 of of IN cord-010092-uftc8inx 953 27 the the DT cord-010092-uftc8inx 953 28 molecular molecular JJ cord-010092-uftc8inx 953 29 assays assay NNS cord-010092-uftc8inx 953 30 used use VBN cord-010092-uftc8inx 953 31 . . . cord-010092-uftc8inx 954 1 The the DT cord-010092-uftc8inx 954 2 nature nature NN cord-010092-uftc8inx 954 3 of of IN cord-010092-uftc8inx 954 4 this this DT cord-010092-uftc8inx 954 5 discrepancy discrepancy NN cord-010092-uftc8inx 954 6 between between IN cord-010092-uftc8inx 954 7 HBsAg HBsAg NNP cord-010092-uftc8inx 954 8 and and CC cord-010092-uftc8inx 954 9 DNA DNA NNP cord-010092-uftc8inx 954 10 remains remain VBZ cord-010092-uftc8inx 954 11 largely largely RB cord-010092-uftc8inx 954 12 unknown unknown JJ cord-010092-uftc8inx 954 13 and and CC cord-010092-uftc8inx 954 14 it -PRON- PRP cord-010092-uftc8inx 954 15 is be VBZ cord-010092-uftc8inx 954 16 essential essential JJ cord-010092-uftc8inx 954 17 to to TO cord-010092-uftc8inx 954 18 evaluate evaluate VB cord-010092-uftc8inx 954 19 any any DT cord-010092-uftc8inx 954 20 potential potential JJ cord-010092-uftc8inx 954 21 negative negative JJ cord-010092-uftc8inx 954 22 impact impact NN cord-010092-uftc8inx 954 23 on on IN cord-010092-uftc8inx 954 24 blood blood NN cord-010092-uftc8inx 954 25 safety safety NN cord-010092-uftc8inx 954 26 before before IN cord-010092-uftc8inx 954 27 considering consider VBG cord-010092-uftc8inx 954 28 removing remove VBG cord-010092-uftc8inx 954 29 HBsAg hbsag ADD cord-010092-uftc8inx 954 30 testing testing NN cord-010092-uftc8inx 954 31 . . . cord-010092-uftc8inx 955 1 Aims aim VBZ cord-010092-uftc8inx 955 2 : : : cord-010092-uftc8inx 956 1 The the DT cord-010092-uftc8inx 956 2 prevalence prevalence NN cord-010092-uftc8inx 956 3 in in IN cord-010092-uftc8inx 956 4 blood blood NN cord-010092-uftc8inx 956 5 donors donor NNS cord-010092-uftc8inx 956 6 and and CC cord-010092-uftc8inx 956 7 the the DT cord-010092-uftc8inx 956 8 molecular molecular JJ cord-010092-uftc8inx 956 9 mechanisms mechanism NNS cord-010092-uftc8inx 956 10 responsible responsible JJ cord-010092-uftc8inx 956 11 for for IN cord-010092-uftc8inx 956 12 a a DT cord-010092-uftc8inx 956 13 persistent persistent JJ cord-010092-uftc8inx 956 14 undetectable undetectable JJ cord-010092-uftc8inx 956 15 or or CC cord-010092-uftc8inx 956 16 barely barely RB cord-010092-uftc8inx 956 17 detectable detectable JJ cord-010092-uftc8inx 956 18 level level NN cord-010092-uftc8inx 956 19 of of IN cord-010092-uftc8inx 956 20 viral viral JJ cord-010092-uftc8inx 956 21 replication replication NN cord-010092-uftc8inx 956 22 in in IN cord-010092-uftc8inx 956 23 the the DT cord-010092-uftc8inx 956 24 presence presence NN cord-010092-uftc8inx 956 25 of of IN cord-010092-uftc8inx 956 26 a a DT cord-010092-uftc8inx 956 27 sustained sustained JJ cord-010092-uftc8inx 956 28 HBsAg hbsag CD cord-010092-uftc8inx 956 29 production production NN cord-010092-uftc8inx 956 30 were be VBD cord-010092-uftc8inx 956 31 investigated investigate VBN cord-010092-uftc8inx 956 32 in in IN cord-010092-uftc8inx 956 33 a a DT cord-010092-uftc8inx 956 34 collaborative collaborative JJ cord-010092-uftc8inx 956 35 study study NN cord-010092-uftc8inx 956 36 including include VBG cord-010092-uftc8inx 956 37 five five CD cord-010092-uftc8inx 956 38 laboratories laboratory NNS cord-010092-uftc8inx 956 39 / / SYM cord-010092-uftc8inx 956 40 blood blood NN cord-010092-uftc8inx 956 41 centers center NNS cord-010092-uftc8inx 956 42 in in IN cord-010092-uftc8inx 956 43 Europe Europe NNP cord-010092-uftc8inx 956 44 and and CC cord-010092-uftc8inx 956 45 South South NNP cord-010092-uftc8inx 956 46 Africa Africa NNP cord-010092-uftc8inx 956 47 . . . cord-010092-uftc8inx 957 1 Discrepancy discrepancy NN cord-010092-uftc8inx 957 2 between between IN cord-010092-uftc8inx 957 3 viral viral JJ cord-010092-uftc8inx 957 4 DNA dna NN cord-010092-uftc8inx 957 5 and and CC cord-010092-uftc8inx 957 6 HBsAg hbsag CD cord-010092-uftc8inx 957 7 levels level NNS cord-010092-uftc8inx 957 8 suggested suggest VBD cord-010092-uftc8inx 957 9 the the DT cord-010092-uftc8inx 957 10 presence presence NN cord-010092-uftc8inx 957 11 of of IN cord-010092-uftc8inx 957 12 mutations mutation NNS cord-010092-uftc8inx 957 13 that that WDT cord-010092-uftc8inx 957 14 may may MD cord-010092-uftc8inx 957 15 negatively negatively RB cord-010092-uftc8inx 957 16 affect affect VB cord-010092-uftc8inx 957 17 HBV HBV NNP cord-010092-uftc8inx 957 18 replication replication NN cord-010092-uftc8inx 957 19 and/or and/or CC cord-010092-uftc8inx 957 20 infectious infectious JJ cord-010092-uftc8inx 957 21 viral viral JJ cord-010092-uftc8inx 957 22 particle particle NN cord-010092-uftc8inx 957 23 production production NN cord-010092-uftc8inx 957 24 . . . cord-010092-uftc8inx 958 1 Methods method NNS cord-010092-uftc8inx 958 2 : : : cord-010092-uftc8inx 958 3 Donor donor NN cord-010092-uftc8inx 958 4 samples sample NNS cord-010092-uftc8inx 958 5 from from IN cord-010092-uftc8inx 958 6 France France NNP cord-010092-uftc8inx 958 7 , , , cord-010092-uftc8inx 958 8 South South NNP cord-010092-uftc8inx 958 9 Africa Africa NNP cord-010092-uftc8inx 958 10 , , , cord-010092-uftc8inx 958 11 Poland Poland NNP cord-010092-uftc8inx 958 12 , , , cord-010092-uftc8inx 958 13 and and CC cord-010092-uftc8inx 958 14 Croatia Croatia NNP cord-010092-uftc8inx 958 15 were be VBD cord-010092-uftc8inx 958 16 selected select VBN cord-010092-uftc8inx 958 17 for for IN cord-010092-uftc8inx 958 18 having have VBG cord-010092-uftc8inx 958 19 HBsAg hbsag ADD cord-010092-uftc8inx 958 20 levels level NNS cord-010092-uftc8inx 958 21 ≥ ≥ CD cord-010092-uftc8inx 958 22 100 100 CD cord-010092-uftc8inx 958 23 IU IU NNP cord-010092-uftc8inx 958 24 / / SYM cord-010092-uftc8inx 958 25 ml ml NN cord-010092-uftc8inx 958 26 and and CC cord-010092-uftc8inx 958 27 being be VBG cord-010092-uftc8inx 958 28 ID ID NNP cord-010092-uftc8inx 958 29 - - HYPH cord-010092-uftc8inx 958 30 NAT NAT NNP cord-010092-uftc8inx 958 31 ( ( -LRB- cord-010092-uftc8inx 958 32 Procleix Procleix NNP cord-010092-uftc8inx 958 33 - - HYPH cord-010092-uftc8inx 958 34 Ultrio Ultrio NNP cord-010092-uftc8inx 958 35 Plus plus CC cord-010092-uftc8inx 958 36 TM TM NNP cord-010092-uftc8inx 958 37 [ [ -LRB- cord-010092-uftc8inx 958 38 95 95 CD cord-010092-uftc8inx 958 39 % % NN cord-010092-uftc8inx 958 40 LOD lod NN cord-010092-uftc8inx 958 41 : : : cord-010092-uftc8inx 958 42 3 3 CD cord-010092-uftc8inx 958 43 IU IU NNP cord-010092-uftc8inx 958 44 / / SYM cord-010092-uftc8inx 958 45 ml ml NN cord-010092-uftc8inx 958 46 ] ] -RRB- cord-010092-uftc8inx 958 47 ) ) -RRB- cord-010092-uftc8inx 958 48 non non JJ cord-010092-uftc8inx 958 49 - - JJ cord-010092-uftc8inx 958 50 reactive reactive JJ cord-010092-uftc8inx 958 51 / / SYM cord-010092-uftc8inx 958 52 non non JJ cord-010092-uftc8inx 958 53 - - JJ cord-010092-uftc8inx 958 54 repeatable repeatable JJ cord-010092-uftc8inx 958 55 reactive reactive JJ cord-010092-uftc8inx 958 56 ( ( -LRB- cord-010092-uftc8inx 958 57 NR NR NNP cord-010092-uftc8inx 958 58 / / SYM cord-010092-uftc8inx 958 59 NRR NRR NNP cord-010092-uftc8inx 958 60 ) ) -RRB- cord-010092-uftc8inx 958 61 with with IN cord-010092-uftc8inx 958 62 undetectable undetectable JJ cord-010092-uftc8inx 958 63 viral viral JJ cord-010092-uftc8inx 958 64 load load NN cord-010092-uftc8inx 958 65 ( ( -LRB- cord-010092-uftc8inx 958 66 VL VL NNP cord-010092-uftc8inx 958 67 ) ) -RRB- cord-010092-uftc8inx 958 68 or or CC cord-010092-uftc8inx 958 69 < < XX cord-010092-uftc8inx 958 70 6 6 CD cord-010092-uftc8inx 959 1 IU IU NNP cord-010092-uftc8inx 959 2 / / , cord-010092-uftc8inx 959 3 ml ml NN cord-010092-uftc8inx 959 4 ( ( -LRB- cord-010092-uftc8inx 959 5 n n NN cord-010092-uftc8inx 959 6 = = SYM cord-010092-uftc8inx 959 7 44 44 CD cord-010092-uftc8inx 959 8 ) ) -RRB- cord-010092-uftc8inx 959 9 or or CC cord-010092-uftc8inx 959 10 NAT NAT NNP cord-010092-uftc8inx 959 11 repeat repeat VBP cord-010092-uftc8inx 959 12 reactive reactive JJ cord-010092-uftc8inx 959 13 ( ( -LRB- cord-010092-uftc8inx 959 14 RR RR NNP cord-010092-uftc8inx 959 15 ) ) -RRB- cord-010092-uftc8inx 959 16 with with IN cord-010092-uftc8inx 959 17 VL VL NNP cord-010092-uftc8inx 959 18 < < XX cord-010092-uftc8inx 960 1 6 6 CD cord-010092-uftc8inx 960 2 IU IU NNP cord-010092-uftc8inx 960 3 / / , cord-010092-uftc8inx 960 4 ml ml NN cord-010092-uftc8inx 961 1 ( ( -LRB- cord-010092-uftc8inx 961 2 n n NN cord-010092-uftc8inx 961 3 = = SYM cord-010092-uftc8inx 961 4 32 32 CD cord-010092-uftc8inx 961 5 ) ) -RRB- cord-010092-uftc8inx 961 6 . . . cord-010092-uftc8inx 962 1 French french JJ cord-010092-uftc8inx 962 2 samples sample NNS cord-010092-uftc8inx 962 3 initially initially RB cord-010092-uftc8inx 962 4 tested test VBD cord-010092-uftc8inx 962 5 NAT NAT NNP cord-010092-uftc8inx 962 6 NR NR NNP cord-010092-uftc8inx 962 7 / / SYM cord-010092-uftc8inx 962 8 NRR NRR NNP cord-010092-uftc8inx 962 9 with with IN cord-010092-uftc8inx 962 10 Procleix Procleix NNP cord-010092-uftc8inx 962 11 - - HYPH cord-010092-uftc8inx 962 12 Ultrio Ultrio NNP cord-010092-uftc8inx 962 13 ( ( -LRB- cord-010092-uftc8inx 962 14 LOD lod NN cord-010092-uftc8inx 962 15 95 95 CD cord-010092-uftc8inx 962 16 % % NN cord-010092-uftc8inx 962 17 : : : cord-010092-uftc8inx 962 18 11 11 CD cord-010092-uftc8inx 962 19 IU IU NNP cord-010092-uftc8inx 962 20 / / SYM cord-010092-uftc8inx 962 21 ml ml NN cord-010092-uftc8inx 962 22 ) ) -RRB- cord-010092-uftc8inx 962 23 were be VBD cord-010092-uftc8inx 962 24 retested reteste VBN cord-010092-uftc8inx 962 25 with with IN cord-010092-uftc8inx 962 26 Ultrio Ultrio NNP cord-010092-uftc8inx 962 27 Plus Plus NNP cord-010092-uftc8inx 962 28 prior prior JJ cord-010092-uftc8inx 962 29 inclusion inclusion NN cord-010092-uftc8inx 962 30 in in IN cord-010092-uftc8inx 962 31 the the DT cord-010092-uftc8inx 962 32 study study NN cord-010092-uftc8inx 962 33 . . . cord-010092-uftc8inx 963 1 HBV HBV NNP cord-010092-uftc8inx 963 2 DNA DNA NNP cord-010092-uftc8inx 963 3 load load NN cord-010092-uftc8inx 963 4 was be VBD cord-010092-uftc8inx 963 5 quantified quantify VBN cord-010092-uftc8inx 963 6 ( ( -LRB- cord-010092-uftc8inx 963 7 Cobas Cobas NNP cord-010092-uftc8inx 963 8 TaqMan TaqMan NNP cord-010092-uftc8inx 963 9 HBV HBV NNP cord-010092-uftc8inx 963 10 [ [ -LRB- cord-010092-uftc8inx 963 11 LOQ LOQ NNP cord-010092-uftc8inx 963 12 : : : cord-010092-uftc8inx 963 13 6 6 CD cord-010092-uftc8inx 963 14 IU IU NNP cord-010092-uftc8inx 963 15 / / SYM cord-010092-uftc8inx 963 16 ml ml NN cord-010092-uftc8inx 963 17 ] ] -RRB- cord-010092-uftc8inx 963 18 ) ) -RRB- cord-010092-uftc8inx 963 19 . . . cord-010092-uftc8inx 964 1 HBV HBV NNP cord-010092-uftc8inx 964 2 DNA DNA NNP cord-010092-uftc8inx 964 3 was be VBD cord-010092-uftc8inx 964 4 purified purify VBN cord-010092-uftc8inx 964 5 from from IN cord-010092-uftc8inx 964 6 5 5 CD cord-010092-uftc8inx 964 7 to to TO cord-010092-uftc8inx 964 8 12 12 CD cord-010092-uftc8inx 964 9 ml ml NNS cord-010092-uftc8inx 964 10 of of IN cord-010092-uftc8inx 964 11 plasma plasma NN cord-010092-uftc8inx 964 12 after after IN cord-010092-uftc8inx 964 13 ultracentrifugation ultracentrifugation NN cord-010092-uftc8inx 964 14 . . . cord-010092-uftc8inx 965 1 The the DT cord-010092-uftc8inx 965 2 whole whole JJ cord-010092-uftc8inx 965 3 HBV HBV NNP cord-010092-uftc8inx 965 4 genome genome NN cord-010092-uftc8inx 965 5 , , , cord-010092-uftc8inx 965 6 Pre Pre NNP cord-010092-uftc8inx 965 7 - - NNP cord-010092-uftc8inx 965 8 S S NNP cord-010092-uftc8inx 965 9 / / SYM cord-010092-uftc8inx 965 10 S S NNP cord-010092-uftc8inx 965 11 , , , cord-010092-uftc8inx 965 12 PreCore PreCore NNP cord-010092-uftc8inx 965 13 / / SYM cord-010092-uftc8inx 965 14 Core Core NNP cord-010092-uftc8inx 965 15 and and CC cord-010092-uftc8inx 965 16 BCP BCP NNP cord-010092-uftc8inx 965 17 regions region NNS cord-010092-uftc8inx 965 18 were be VBD cord-010092-uftc8inx 965 19 amplified amplify VBN cord-010092-uftc8inx 965 20 and and CC cord-010092-uftc8inx 965 21 sequenced sequence VBN cord-010092-uftc8inx 965 22 . . . cord-010092-uftc8inx 966 1 Results result NNS cord-010092-uftc8inx 966 2 : : : cord-010092-uftc8inx 967 1 Following follow VBG cord-010092-uftc8inx 967 2 viral viral JJ cord-010092-uftc8inx 967 3 concentration concentration NN cord-010092-uftc8inx 967 4 , , , cord-010092-uftc8inx 967 5 HBV HBV NNP cord-010092-uftc8inx 967 6 DNA DNA NNP cord-010092-uftc8inx 967 7 presence presence NN cord-010092-uftc8inx 967 8 was be VBD cord-010092-uftc8inx 967 9 confirmed confirm VBN cord-010092-uftc8inx 967 10 in in IN cord-010092-uftc8inx 967 11 79 79 CD cord-010092-uftc8inx 967 12 % % NN cord-010092-uftc8inx 967 13 of of IN cord-010092-uftc8inx 967 14 all all DT cord-010092-uftc8inx 967 15 samples sample NNS cord-010092-uftc8inx 967 16 with with IN cord-010092-uftc8inx 967 17 undetectable undetectable JJ cord-010092-uftc8inx 967 18 or or CC cord-010092-uftc8inx 967 19 VL VL NNP cord-010092-uftc8inx 967 20 < < XX cord-010092-uftc8inx 967 21 6 6 CD cord-010092-uftc8inx 968 1 IU IU NNP cord-010092-uftc8inx 968 2 / / , cord-010092-uftc8inx 968 3 ml ml NN cord-010092-uftc8inx 968 4 . . . cord-010092-uftc8inx 969 1 HBV HBV NNP cord-010092-uftc8inx 969 2 genotypes genotype NNS cord-010092-uftc8inx 969 3 were be VBD cord-010092-uftc8inx 969 4 A1 A1 NNP cord-010092-uftc8inx 969 5 ( ( -LRB- cord-010092-uftc8inx 969 6 33.3 33.3 CD cord-010092-uftc8inx 969 7 % % NN cord-010092-uftc8inx 969 8 ) ) -RRB- cord-010092-uftc8inx 969 9 , , , cord-010092-uftc8inx 969 10 A2 A2 NNP cord-010092-uftc8inx 969 11 ( ( -LRB- cord-010092-uftc8inx 969 12 18.4 18.4 CD cord-010092-uftc8inx 969 13 % % NN cord-010092-uftc8inx 969 14 ) ) -RRB- cord-010092-uftc8inx 969 15 , , , cord-010092-uftc8inx 969 16 A3 A3 NNP cord-010092-uftc8inx 969 17 ( ( -LRB- cord-010092-uftc8inx 969 18 3.3 3.3 CD cord-010092-uftc8inx 969 19 % % NN cord-010092-uftc8inx 969 20 ) ) -RRB- cord-010092-uftc8inx 969 21 , , , cord-010092-uftc8inx 969 22 B B NNP cord-010092-uftc8inx 969 23 ( ( -LRB- cord-010092-uftc8inx 969 24 3.3 3.3 CD cord-010092-uftc8inx 969 25 % % NN cord-010092-uftc8inx 969 26 ) ) -RRB- cord-010092-uftc8inx 969 27 , , , cord-010092-uftc8inx 969 28 C C NNP cord-010092-uftc8inx 969 29 ( ( -LRB- cord-010092-uftc8inx 969 30 1.7 1.7 CD cord-010092-uftc8inx 969 31 % % NN cord-010092-uftc8inx 969 32 ) ) -RRB- cord-010092-uftc8inx 969 33 , , , cord-010092-uftc8inx 969 34 D D NNP cord-010092-uftc8inx 969 35 ( ( -LRB- cord-010092-uftc8inx 969 36 25 25 CD cord-010092-uftc8inx 969 37 % % NN cord-010092-uftc8inx 969 38 ) ) -RRB- cord-010092-uftc8inx 969 39 , , , cord-010092-uftc8inx 969 40 and and CC cord-010092-uftc8inx 969 41 E E NNP cord-010092-uftc8inx 969 42 ( ( -LRB- cord-010092-uftc8inx 969 43 15 15 CD cord-010092-uftc8inx 969 44 % % NN cord-010092-uftc8inx 969 45 ) ) -RRB- cord-010092-uftc8inx 969 46 . . . cord-010092-uftc8inx 970 1 All all DT cord-010092-uftc8inx 970 2 samples sample NNS cord-010092-uftc8inx 970 3 were be VBD cord-010092-uftc8inx 970 4 anti anti JJ cord-010092-uftc8inx 970 5 - - JJ cord-010092-uftc8inx 970 6 HBc hbc JJ cord-010092-uftc8inx 970 7 positive positive JJ cord-010092-uftc8inx 970 8 and and CC cord-010092-uftc8inx 970 9 73 73 CD cord-010092-uftc8inx 970 10 % % NN cord-010092-uftc8inx 970 11 of of IN cord-010092-uftc8inx 970 12 Ultrio Ultrio NNP cord-010092-uftc8inx 970 13 - - HYPH cord-010092-uftc8inx 970 14 negative negative JJ cord-010092-uftc8inx 970 15 samples sample NNS cord-010092-uftc8inx 970 16 tested test VBN cord-010092-uftc8inx 970 17 positive positive JJ cord-010092-uftc8inx 970 18 with with IN cord-010092-uftc8inx 970 19 Ultrio Ultrio NNP cord-010092-uftc8inx 970 20 Plus Plus NNP cord-010092-uftc8inx 970 21 . . . cord-010092-uftc8inx 971 1 Unusual unusual JJ cord-010092-uftc8inx 971 2 1 1 CD cord-010092-uftc8inx 971 3 - - SYM cord-010092-uftc8inx 971 4 2 2 CD cord-010092-uftc8inx 971 5 nt nt NNP cord-010092-uftc8inx 971 6 insertions insertion NNS cord-010092-uftc8inx 971 7 / / SYM cord-010092-uftc8inx 971 8 deletions deletion NNS cord-010092-uftc8inx 971 9 identified identify VBN cord-010092-uftc8inx 971 10 in in IN cord-010092-uftc8inx 971 11 BCP BCP NNP cord-010092-uftc8inx 971 12 regulatory regulatory JJ cord-010092-uftc8inx 971 13 elements element NNS cord-010092-uftc8inx 971 14 ( ( -LRB- cord-010092-uftc8inx 971 15 TATA TATA NNP cord-010092-uftc8inx 971 16 boxes box NNS cord-010092-uftc8inx 971 17 , , , cord-010092-uftc8inx 971 18 pgInr pginr NN cord-010092-uftc8inx 971 19 , , , cord-010092-uftc8inx 971 20 epsilon epsilon NN cord-010092-uftc8inx 971 21 domain domain NN cord-010092-uftc8inx 971 22 ) ) -RRB- cord-010092-uftc8inx 971 23 suggest suggest VBP cord-010092-uftc8inx 971 24 altered alter VBN cord-010092-uftc8inx 971 25 viral viral JJ cord-010092-uftc8inx 971 26 replication replication NN cord-010092-uftc8inx 971 27 . . . cord-010092-uftc8inx 972 1 Amino amino NN cord-010092-uftc8inx 972 2 acid acid NN cord-010092-uftc8inx 972 3 substitutions substitution NNS cord-010092-uftc8inx 972 4 ( ( -LRB- cord-010092-uftc8inx 972 5 n n NN cord-010092-uftc8inx 972 6 = = SYM cord-010092-uftc8inx 972 7 16 16 CD cord-010092-uftc8inx 972 8 ) ) -RRB- cord-010092-uftc8inx 972 9 or or CC cord-010092-uftc8inx 972 10 deletions deletion NNS cord-010092-uftc8inx 972 11 ( ( -LRB- cord-010092-uftc8inx 972 12 n n NN cord-010092-uftc8inx 972 13 = = SYM cord-010092-uftc8inx 972 14 4 4 CD cord-010092-uftc8inx 972 15 ) ) -RRB- cord-010092-uftc8inx 972 16 at at IN cord-010092-uftc8inx 972 17 positions position NNS cord-010092-uftc8inx 972 18 reported report VBN cord-010092-uftc8inx 972 19 involved involve VBN cord-010092-uftc8inx 972 20 in in IN cord-010092-uftc8inx 972 21 nucleocapsid nucleocapsid NNP cord-010092-uftc8inx 972 22 formation formation NN cord-010092-uftc8inx 972 23 , , , cord-010092-uftc8inx 972 24 particle particle NN cord-010092-uftc8inx 972 25 envelopment envelopment NN cord-010092-uftc8inx 972 26 and and CC cord-010092-uftc8inx 972 27 virion virion NN cord-010092-uftc8inx 972 28 formation formation NN cord-010092-uftc8inx 972 29 were be VBD cord-010092-uftc8inx 972 30 observed observe VBN cord-010092-uftc8inx 972 31 in in IN cord-010092-uftc8inx 972 32 the the DT cord-010092-uftc8inx 972 33 core core NN cord-010092-uftc8inx 972 34 protein protein NN cord-010092-uftc8inx 972 35 of of IN cord-010092-uftc8inx 972 36 30 30 CD cord-010092-uftc8inx 972 37 samples sample NNS cord-010092-uftc8inx 972 38 . . . cord-010092-uftc8inx 973 1 The the DT cord-010092-uftc8inx 973 2 replicative replicative JJ cord-010092-uftc8inx 973 3 properties property NNS cord-010092-uftc8inx 973 4 of of IN cord-010092-uftc8inx 973 5 the the DT cord-010092-uftc8inx 973 6 BCP BCP NNP cord-010092-uftc8inx 973 7 and and CC cord-010092-uftc8inx 973 8 core core NN cord-010092-uftc8inx 973 9 variants variant NNS cord-010092-uftc8inx 973 10 are be VBP cord-010092-uftc8inx 973 11 currently currently RB cord-010092-uftc8inx 973 12 evaluated evaluate VBN cord-010092-uftc8inx 973 13 in in IN cord-010092-uftc8inx 973 14 vitro vitro FW cord-010092-uftc8inx 973 15 as as IN cord-010092-uftc8inx 973 16 a a DT cord-010092-uftc8inx 973 17 surrogate surrogate JJ cord-010092-uftc8inx 973 18 model model NN cord-010092-uftc8inx 973 19 for for IN cord-010092-uftc8inx 973 20 direct direct JJ cord-010092-uftc8inx 973 21 infectivity infectivity NN cord-010092-uftc8inx 973 22 testing testing NN cord-010092-uftc8inx 973 23 . . . cord-010092-uftc8inx 974 1 Preliminary preliminary JJ cord-010092-uftc8inx 974 2 results result NNS cord-010092-uftc8inx 974 3 indicate indicate VBP cord-010092-uftc8inx 974 4 that that IN cord-010092-uftc8inx 974 5 the the DT cord-010092-uftc8inx 974 6 variants variant NNS cord-010092-uftc8inx 974 7 tested test VBN cord-010092-uftc8inx 974 8 so so RB cord-010092-uftc8inx 974 9 far far RB cord-010092-uftc8inx 974 10 have have VBP cord-010092-uftc8inx 974 11 replicative replicative JJ cord-010092-uftc8inx 974 12 capabilities capability NNS cord-010092-uftc8inx 974 13 similar similar JJ cord-010092-uftc8inx 974 14 to to IN cord-010092-uftc8inx 974 15 those those DT cord-010092-uftc8inx 974 16 of of IN cord-010092-uftc8inx 974 17 control control NN cord-010092-uftc8inx 974 18 viruses virus NNS cord-010092-uftc8inx 974 19 . . . cord-010092-uftc8inx 975 1 Analysis analysis NN cord-010092-uftc8inx 975 2 of of IN cord-010092-uftc8inx 975 3 Pol Pol NNP cord-010092-uftc8inx 975 4 , , , cord-010092-uftc8inx 975 5 S S NNP cord-010092-uftc8inx 975 6 , , , cord-010092-uftc8inx 976 1 and and CC cord-010092-uftc8inx 976 2 HBx hbx NN cord-010092-uftc8inx 976 3 proteins protein NNS cord-010092-uftc8inx 976 4 is be VBZ cord-010092-uftc8inx 976 5 ongoing ongoing JJ cord-010092-uftc8inx 976 6 . . . cord-010092-uftc8inx 977 1 Summary Summary NNP cord-010092-uftc8inx 977 2 / / SYM cord-010092-uftc8inx 977 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 977 4 : : : cord-010092-uftc8inx 978 1 These these DT cord-010092-uftc8inx 978 2 data datum NNS cord-010092-uftc8inx 978 3 confirmed confirm VBD cord-010092-uftc8inx 978 4 the the DT cord-010092-uftc8inx 978 5 presence presence NN cord-010092-uftc8inx 978 6 of of IN cord-010092-uftc8inx 978 7 extremely extremely RB cord-010092-uftc8inx 978 8 low low JJ cord-010092-uftc8inx 978 9 level level NN cord-010092-uftc8inx 978 10 of of IN cord-010092-uftc8inx 978 11 circulating circulate VBG cord-010092-uftc8inx 978 12 DNA dna NN cord-010092-uftc8inx 978 13 - - HYPH cord-010092-uftc8inx 978 14 containing contain VBG cord-010092-uftc8inx 978 15 viral viral JJ cord-010092-uftc8inx 978 16 particles particle NNS cord-010092-uftc8inx 978 17 in in IN cord-010092-uftc8inx 978 18 ID ID NNP cord-010092-uftc8inx 978 19 - - HYPH cord-010092-uftc8inx 978 20 NAT NAT NNP cord-010092-uftc8inx 978 21 non non JJ cord-010092-uftc8inx 978 22 - - JJ cord-010092-uftc8inx 978 23 reactive reactive JJ cord-010092-uftc8inx 978 24 or or CC cord-010092-uftc8inx 978 25 nonrepeated nonrepeate VBN cord-010092-uftc8inx 978 26 reactive reactive JJ cord-010092-uftc8inx 978 27 blood blood NN cord-010092-uftc8inx 978 28 donations donation NNS cord-010092-uftc8inx 978 29 with with IN cord-010092-uftc8inx 978 30 concomitant concomitant JJ cord-010092-uftc8inx 978 31 high high JJ cord-010092-uftc8inx 978 32 HBsAg hbsag CD cord-010092-uftc8inx 978 33 levels level NNS cord-010092-uftc8inx 978 34 and and CC cord-010092-uftc8inx 978 35 anti anti JJ cord-010092-uftc8inx 978 36 - - JJ cord-010092-uftc8inx 978 37 HBc hbc JJ cord-010092-uftc8inx 978 38 reactivity reactivity NN cord-010092-uftc8inx 978 39 . . . cord-010092-uftc8inx 979 1 Despite despite IN cord-010092-uftc8inx 979 2 the the DT cord-010092-uftc8inx 979 3 presence presence NN cord-010092-uftc8inx 979 4 of of IN cord-010092-uftc8inx 979 5 mutations mutation NNS cord-010092-uftc8inx 979 6 in in IN cord-010092-uftc8inx 979 7 the the DT cord-010092-uftc8inx 979 8 viral viral JJ cord-010092-uftc8inx 979 9 genomes genome NNS cord-010092-uftc8inx 979 10 potentially potentially RB cord-010092-uftc8inx 979 11 affecting affect VBG cord-010092-uftc8inx 979 12 virion virion NN cord-010092-uftc8inx 979 13 production production NN cord-010092-uftc8inx 979 14 , , , cord-010092-uftc8inx 979 15 preliminary preliminary JJ cord-010092-uftc8inx 979 16 data datum NNS cord-010092-uftc8inx 979 17 indicate indicate VBP cord-010092-uftc8inx 979 18 that that IN cord-010092-uftc8inx 979 19 some some DT cord-010092-uftc8inx 979 20 of of IN cord-010092-uftc8inx 979 21 the the DT cord-010092-uftc8inx 979 22 viruses virus NNS cord-010092-uftc8inx 979 23 in in IN cord-010092-uftc8inx 979 24 plasma plasma NN cord-010092-uftc8inx 979 25 retain retain VBP cord-010092-uftc8inx 979 26 the the DT cord-010092-uftc8inx 979 27 ability ability NN cord-010092-uftc8inx 979 28 to to TO cord-010092-uftc8inx 979 29 replicate replicate VB cord-010092-uftc8inx 979 30 in in IN cord-010092-uftc8inx 979 31 vitro vitro FW cord-010092-uftc8inx 979 32 and and CC cord-010092-uftc8inx 979 33 to to TO cord-010092-uftc8inx 979 34 constitute constitute VB cord-010092-uftc8inx 979 35 a a DT cord-010092-uftc8inx 979 36 potential potential JJ cord-010092-uftc8inx 979 37 infectious infectious JJ cord-010092-uftc8inx 979 38 risk risk NN cord-010092-uftc8inx 979 39 . . . cord-010092-uftc8inx 980 1 3C 3C NNP cord-010092-uftc8inx 980 2 - - HYPH cord-010092-uftc8inx 980 3 S08 S08 NNP cord-010092-uftc8inx 980 4 - - HYPH cord-010092-uftc8inx 980 5 03 03 CD cord-010092-uftc8inx 980 6 Background background NN cord-010092-uftc8inx 980 7 : : : cord-010092-uftc8inx 981 1 In in IN cord-010092-uftc8inx 981 2 Switzerland Switzerland NNP cord-010092-uftc8inx 981 3 highly highly RB cord-010092-uftc8inx 981 4 sensitive sensitive JJ cord-010092-uftc8inx 981 5 nucleic nucleic JJ cord-010092-uftc8inx 981 6 acid acid NN cord-010092-uftc8inx 981 7 screening screening NN cord-010092-uftc8inx 981 8 in in IN cord-010092-uftc8inx 981 9 an an DT cord-010092-uftc8inx 981 10 individual individual JJ cord-010092-uftc8inx 981 11 donation donation NN cord-010092-uftc8inx 981 12 format format NN cord-010092-uftc8inx 981 13 for for IN cord-010092-uftc8inx 981 14 hepatitis hepatitis NNP cord-010092-uftc8inx 981 15 B B NNP cord-010092-uftc8inx 981 16 virus virus NN cord-010092-uftc8inx 981 17 ( ( -LRB- cord-010092-uftc8inx 981 18 HBV HBV NNP cord-010092-uftc8inx 981 19 ID ID NNP cord-010092-uftc8inx 981 20 - - HYPH cord-010092-uftc8inx 981 21 NAT NAT NNP cord-010092-uftc8inx 981 22 ) ) -RRB- cord-010092-uftc8inx 981 23 and and CC cord-010092-uftc8inx 982 1 hepatitis hepatitis NNP cord-010092-uftc8inx 982 2 B B NNP cord-010092-uftc8inx 982 3 surface surface NN cord-010092-uftc8inx 982 4 antigen antigen NN cord-010092-uftc8inx 982 5 ( ( -LRB- cord-010092-uftc8inx 982 6 HBsAg HBsAg NNP cord-010092-uftc8inx 982 7 ) ) -RRB- cord-010092-uftc8inx 982 8 detection detection NN cord-010092-uftc8inx 982 9 is be VBZ cord-010092-uftc8inx 982 10 mandatorily mandatorily RB cord-010092-uftc8inx 982 11 performed perform VBN cord-010092-uftc8inx 982 12 ( ( -LRB- cord-010092-uftc8inx 982 13 guidelines guideline NNS cord-010092-uftc8inx 982 14 of of IN cord-010092-uftc8inx 982 15 Swiss Swiss NNP cord-010092-uftc8inx 982 16 Transfusion Transfusion NNP cord-010092-uftc8inx 982 17 SRC SRC NNP cord-010092-uftc8inx 982 18 , , , cord-010092-uftc8inx 982 19 Switzerland Switzerland NNP cord-010092-uftc8inx 982 20 ) ) -RRB- cord-010092-uftc8inx 982 21 . . . cord-010092-uftc8inx 983 1 Since since IN cord-010092-uftc8inx 983 2 1998 1998 CD cord-010092-uftc8inx 983 3 , , , cord-010092-uftc8inx 983 4 HBV HBV NNP cord-010092-uftc8inx 983 5 ( ( -LRB- cord-010092-uftc8inx 983 6 HB HB NNP cord-010092-uftc8inx 983 7 ) ) -RRB- cord-010092-uftc8inx 983 8 vaccination vaccination NN cord-010092-uftc8inx 983 9 is be VBZ cord-010092-uftc8inx 983 10 recommended recommend VBN cord-010092-uftc8inx 983 11 in in IN cord-010092-uftc8inx 983 12 Switzerland Switzerland NNP cord-010092-uftc8inx 983 13 for for IN cord-010092-uftc8inx 983 14 children child NNS cord-010092-uftc8inx 983 15 and and CC cord-010092-uftc8inx 983 16 adolescents adolescent NNS cord-010092-uftc8inx 983 17 until until IN cord-010092-uftc8inx 983 18 the the DT cord-010092-uftc8inx 983 19 age age NN cord-010092-uftc8inx 983 20 of of IN cord-010092-uftc8inx 983 21 15 15 CD cord-010092-uftc8inx 983 22 and and CC cord-010092-uftc8inx 983 23 for for IN cord-010092-uftc8inx 983 24 adults adult NNS cord-010092-uftc8inx 983 25 belonging belong VBG cord-010092-uftc8inx 983 26 to to IN cord-010092-uftc8inx 983 27 known know VBN cord-010092-uftc8inx 983 28 risk risk NN cord-010092-uftc8inx 983 29 groups group NNS cord-010092-uftc8inx 983 30 . . . cord-010092-uftc8inx 984 1 Aims aim VBZ cord-010092-uftc8inx 984 2 : : : cord-010092-uftc8inx 984 3 To to TO cord-010092-uftc8inx 984 4 highlight highlight VB cord-010092-uftc8inx 984 5 that that DT cord-010092-uftc8inx 984 6 low low JJ cord-010092-uftc8inx 984 7 anti anti JJ cord-010092-uftc8inx 984 8 - - JJ cord-010092-uftc8inx 984 9 HBs hbs JJ cord-010092-uftc8inx 984 10 titers titer NNS cord-010092-uftc8inx 984 11 several several JJ cord-010092-uftc8inx 984 12 years year NNS cord-010092-uftc8inx 984 13 following follow VBG cord-010092-uftc8inx 984 14 HBV HBV NNP cord-010092-uftc8inx 984 15 vaccination vaccination NN cord-010092-uftc8inx 984 16 still still RB cord-010092-uftc8inx 984 17 confer confer VBP cord-010092-uftc8inx 984 18 protection protection NN cord-010092-uftc8inx 984 19 and and CC cord-010092-uftc8inx 984 20 enable enable VB cord-010092-uftc8inx 984 21 the the DT cord-010092-uftc8inx 984 22 host host NN cord-010092-uftc8inx 984 23 immune immune JJ cord-010092-uftc8inx 984 24 system system NN cord-010092-uftc8inx 984 25 to to TO cord-010092-uftc8inx 984 26 clear clear VB cord-010092-uftc8inx 984 27 HBV HBV NNP cord-010092-uftc8inx 984 28 DNA DNA NNP cord-010092-uftc8inx 984 29 without without IN cord-010092-uftc8inx 984 30 development development NN cord-010092-uftc8inx 984 31 of of IN cord-010092-uftc8inx 984 32 serologic serologic JJ cord-010092-uftc8inx 984 33 markers marker NNS cord-010092-uftc8inx 984 34 of of IN cord-010092-uftc8inx 984 35 disease disease NN cord-010092-uftc8inx 984 36 . . . cord-010092-uftc8inx 985 1 Methods method NNS cord-010092-uftc8inx 985 2 : : : cord-010092-uftc8inx 985 3 A a DT cord-010092-uftc8inx 985 4 retrospective retrospective JJ cord-010092-uftc8inx 985 5 donor donor NN cord-010092-uftc8inx 985 6 interview interview NN cord-010092-uftc8inx 985 7 was be VBD cord-010092-uftc8inx 985 8 conducted conduct VBN cord-010092-uftc8inx 985 9 to to TO cord-010092-uftc8inx 985 10 complete complete VB cord-010092-uftc8inx 985 11 information information NN cord-010092-uftc8inx 985 12 not not RB cord-010092-uftc8inx 985 13 covered cover VBN cord-010092-uftc8inx 985 14 by by IN cord-010092-uftc8inx 985 15 the the DT cord-010092-uftc8inx 985 16 questions question NNS cord-010092-uftc8inx 985 17 included include VBN cord-010092-uftc8inx 985 18 in in IN cord-010092-uftc8inx 985 19 the the DT cord-010092-uftc8inx 985 20 standard standard JJ cord-010092-uftc8inx 985 21 donor donor NN cord-010092-uftc8inx 985 22 questionnaire questionnaire NN cord-010092-uftc8inx 985 23 . . . cord-010092-uftc8inx 986 1 Routine routine JJ cord-010092-uftc8inx 986 2 HBV HBV NNP cord-010092-uftc8inx 986 3 serological serological JJ cord-010092-uftc8inx 986 4 donor donor NN cord-010092-uftc8inx 986 5 screening screening NN cord-010092-uftc8inx 986 6 was be VBD cord-010092-uftc8inx 986 7 performed perform VBN cord-010092-uftc8inx 986 8 on on IN cord-010092-uftc8inx 986 9 a a DT cord-010092-uftc8inx 986 10 Quadriga Quadriga NNP cord-010092-uftc8inx 986 11 system system NN cord-010092-uftc8inx 986 12 ( ( -LRB- cord-010092-uftc8inx 986 13 Diasorin Diasorin NNP cord-010092-uftc8inx 986 14 , , , cord-010092-uftc8inx 986 15 former former JJ cord-010092-uftc8inx 986 16 Siemens Siemens NNP cord-010092-uftc8inx 986 17 ) ) -RRB- cord-010092-uftc8inx 986 18 with with IN cord-010092-uftc8inx 986 19 the the DT cord-010092-uftc8inx 986 20 Enzygnost Enzygnost NNP cord-010092-uftc8inx 986 21 HBsAg hbsag CD cord-010092-uftc8inx 986 22 assay assay NN cord-010092-uftc8inx 986 23 ( ( -LRB- cord-010092-uftc8inx 986 24 Diasorin Diasorin NNP cord-010092-uftc8inx 986 25 , , , cord-010092-uftc8inx 986 26 former former JJ cord-010092-uftc8inx 986 27 Siemens Siemens NNP cord-010092-uftc8inx 986 28 ) ) -RRB- cord-010092-uftc8inx 986 29 . . . cord-010092-uftc8inx 987 1 Further further JJ cord-010092-uftc8inx 987 2 HBV HBV NNP cord-010092-uftc8inx 987 3 tests test NNS cord-010092-uftc8inx 987 4 were be VBD cord-010092-uftc8inx 987 5 performed perform VBN cord-010092-uftc8inx 987 6 on on IN cord-010092-uftc8inx 987 7 the the DT cord-010092-uftc8inx 987 8 Abbott Abbott NNP cord-010092-uftc8inx 987 9 Architect Architect NNP cord-010092-uftc8inx 987 10 i1000 i1000 NNP cord-010092-uftc8inx 987 11 analyser analyser NN cord-010092-uftc8inx 987 12 ( ( -LRB- cord-010092-uftc8inx 987 13 HBsAg hbsag ADD cord-010092-uftc8inx 987 14 neutralisation neutralisation NN cord-010092-uftc8inx 987 15 , , , cord-010092-uftc8inx 987 16 HBeAg hbeag CD cord-010092-uftc8inx 987 17 , , , cord-010092-uftc8inx 987 18 anti anti JJ cord-010092-uftc8inx 987 19 - - JJ cord-010092-uftc8inx 987 20 HBc hbc JJ cord-010092-uftc8inx 987 21 IgG IgG NNP cord-010092-uftc8inx 987 22 / / SYM cord-010092-uftc8inx 987 23 IgM IgM NNP cord-010092-uftc8inx 987 24 , , , cord-010092-uftc8inx 987 25 anti anti JJ cord-010092-uftc8inx 987 26 - - JJ cord-010092-uftc8inx 987 27 HBc hbc JJ cord-010092-uftc8inx 987 28 IgM IgM NNP cord-010092-uftc8inx 987 29 , , , cord-010092-uftc8inx 987 30 anti anti JJ cord-010092-uftc8inx 987 31 - - JJ cord-010092-uftc8inx 987 32 HBe hbe JJ cord-010092-uftc8inx 987 33 and and CC cord-010092-uftc8inx 987 34 anti anti JJ cord-010092-uftc8inx 987 35 - - JJ cord-010092-uftc8inx 987 36 HBs HBs NNP cord-010092-uftc8inx 987 37 ) ) -RRB- cord-010092-uftc8inx 987 38 . . . cord-010092-uftc8inx 988 1 Routine routine JJ cord-010092-uftc8inx 988 2 ID ID NNP cord-010092-uftc8inx 988 3 - - HYPH cord-010092-uftc8inx 988 4 NAT NAT NNP cord-010092-uftc8inx 988 5 screening screening NN cord-010092-uftc8inx 988 6 for for IN cord-010092-uftc8inx 989 1 HIV HIV NNP cord-010092-uftc8inx 989 2 / / SYM cord-010092-uftc8inx 989 3 HCV HCV NNP cord-010092-uftc8inx 989 4 / / SYM cord-010092-uftc8inx 989 5 HBV HBV NNP cord-010092-uftc8inx 989 6 was be VBD cord-010092-uftc8inx 989 7 performed perform VBN cord-010092-uftc8inx 989 8 with with IN cord-010092-uftc8inx 989 9 the the DT cord-010092-uftc8inx 989 10 Roche Roche NNP cord-010092-uftc8inx 989 11 cobas cobas NN cord-010092-uftc8inx 989 12 MPX MPX NNP cord-010092-uftc8inx 989 13 test test VBP cord-010092-uftc8inx 989 14 on on IN cord-010092-uftc8inx 989 15 a a DT cord-010092-uftc8inx 989 16 Roche Roche NNP cord-010092-uftc8inx 989 17 cobas cobas NNP cord-010092-uftc8inx 989 18 8800 8800 CD cord-010092-uftc8inx 989 19 platform platform NN cord-010092-uftc8inx 989 20 . . . cord-010092-uftc8inx 990 1 HBV HBV NNP cord-010092-uftc8inx 990 2 ID ID NNP cord-010092-uftc8inx 990 3 - - HYPH cord-010092-uftc8inx 990 4 NAT NAT NNP cord-010092-uftc8inx 990 5 positive positive JJ cord-010092-uftc8inx 990 6 samples sample NNS cord-010092-uftc8inx 990 7 were be VBD cord-010092-uftc8inx 990 8 confirmed confirm VBN cord-010092-uftc8inx 990 9 with with IN cord-010092-uftc8inx 990 10 a a DT cord-010092-uftc8inx 990 11 quantitative quantitative JJ cord-010092-uftc8inx 990 12 HBV HBV NNP cord-010092-uftc8inx 990 13 NAT NAT NNP cord-010092-uftc8inx 990 14 assay assay NN cord-010092-uftc8inx 990 15 ( ( -LRB- cord-010092-uftc8inx 990 16 Abbott Abbott NNP cord-010092-uftc8inx 990 17 ) ) -RRB- cord-010092-uftc8inx 990 18 . . . cord-010092-uftc8inx 991 1 Background background NN cord-010092-uftc8inx 991 2 : : : cord-010092-uftc8inx 992 1 Hepatitis Hepatitis NNP cord-010092-uftc8inx 992 2 B b NN cord-010092-uftc8inx 992 3 core core NN cord-010092-uftc8inx 992 4 - - HYPH cord-010092-uftc8inx 992 5 related relate VBN cord-010092-uftc8inx 992 6 antigen antigen NN cord-010092-uftc8inx 992 7 ( ( -LRB- cord-010092-uftc8inx 992 8 HBcrAg HBcrAg NNP cord-010092-uftc8inx 992 9 ) ) -RRB- cord-010092-uftc8inx 992 10 is be VBZ cord-010092-uftc8inx 992 11 a a DT cord-010092-uftc8inx 992 12 structural structural JJ cord-010092-uftc8inx 992 13 antigen antigen NN cord-010092-uftc8inx 992 14 of of IN cord-010092-uftc8inx 992 15 HBV HBV NNP cord-010092-uftc8inx 992 16 , , , cord-010092-uftc8inx 992 17 consisting consist VBG cord-010092-uftc8inx 992 18 in in IN cord-010092-uftc8inx 992 19 HBCAg HBCAg NNP cord-010092-uftc8inx 992 20 , , , cord-010092-uftc8inx 992 21 HBeAg hbeag CD cord-010092-uftc8inx 992 22 and and CC cord-010092-uftc8inx 992 23 the the DT cord-010092-uftc8inx 992 24 p22cr p22cr NNP cord-010092-uftc8inx 992 25 precore precore NN cord-010092-uftc8inx 992 26 protein protein NN cord-010092-uftc8inx 992 27 . . . cord-010092-uftc8inx 993 1 Quantitative Quantitative NNP cord-010092-uftc8inx 993 2 HBcrAg HBcrAg NNP cord-010092-uftc8inx 993 3 measurement measurement NN cord-010092-uftc8inx 993 4 is be VBZ cord-010092-uftc8inx 993 5 a a DT cord-010092-uftc8inx 993 6 sensitive sensitive JJ cord-010092-uftc8inx 993 7 marker marker NN cord-010092-uftc8inx 993 8 of of IN cord-010092-uftc8inx 993 9 viral viral JJ cord-010092-uftc8inx 993 10 replication replication NN cord-010092-uftc8inx 993 11 reflecting reflect VBG cord-010092-uftc8inx 993 12 the the DT cord-010092-uftc8inx 993 13 cccDNA cccDNA NNP cord-010092-uftc8inx 993 14 content content NN cord-010092-uftc8inx 993 15 and and CC cord-010092-uftc8inx 993 16 persistence persistence NN cord-010092-uftc8inx 993 17 of of IN cord-010092-uftc8inx 993 18 disease disease NN cord-010092-uftc8inx 993 19 . . . cord-010092-uftc8inx 994 1 HBcrAg HBcrAg NNP cord-010092-uftc8inx 994 2 positivity positivity NN cord-010092-uftc8inx 994 3 was be VBD cord-010092-uftc8inx 994 4 found find VBN cord-010092-uftc8inx 994 5 to to TO cord-010092-uftc8inx 994 6 be be VB cord-010092-uftc8inx 994 7 a a DT cord-010092-uftc8inx 994 8 significant significant JJ cord-010092-uftc8inx 994 9 risk risk NN cord-010092-uftc8inx 994 10 factor factor NN cord-010092-uftc8inx 994 11 of of IN cord-010092-uftc8inx 994 12 HBV HBV NNP cord-010092-uftc8inx 994 13 reactivation reactivation NN cord-010092-uftc8inx 994 14 in in IN cord-010092-uftc8inx 994 15 HBsAg- HBsAg- NNP cord-010092-uftc8inx 994 16 , , , cord-010092-uftc8inx 994 17 anti anti JJ cord-010092-uftc8inx 994 18 - - NN cord-010092-uftc8inx 994 19 HBc+ hbc+ JJ cord-010092-uftc8inx 994 20 , , , cord-010092-uftc8inx 994 21 HBV HBV NNP cord-010092-uftc8inx 994 22 DNA dna NN cord-010092-uftc8inx 994 23 - - HYPH cord-010092-uftc8inx 994 24 patients patient NNS cord-010092-uftc8inx 994 25 ( ( -LRB- cord-010092-uftc8inx 994 26 occult occult JJ cord-010092-uftc8inx 994 27 HBV HBV NNP cord-010092-uftc8inx 994 28 infection infection NN cord-010092-uftc8inx 994 29 , , , cord-010092-uftc8inx 994 30 OBI OBI NNP cord-010092-uftc8inx 994 31 ) ) -RRB- cord-010092-uftc8inx 994 32 undergoing undergo VBG cord-010092-uftc8inx 994 33 immunosuppressive immunosuppressive JJ cord-010092-uftc8inx 994 34 therapy therapy NN cord-010092-uftc8inx 994 35 . . . cord-010092-uftc8inx 995 1 Aims aim VBZ cord-010092-uftc8inx 995 2 : : : cord-010092-uftc8inx 996 1 No no DT cord-010092-uftc8inx 996 2 data datum NNS cord-010092-uftc8inx 996 3 about about IN cord-010092-uftc8inx 996 4 HBcrAg HBcrAg NNP cord-010092-uftc8inx 996 5 status status NN cord-010092-uftc8inx 996 6 in in IN cord-010092-uftc8inx 996 7 apparently apparently RB cord-010092-uftc8inx 996 8 healthy healthy JJ cord-010092-uftc8inx 996 9 subject subject NN cord-010092-uftc8inx 996 10 with with IN cord-010092-uftc8inx 996 11 OBI OBI NNP cord-010092-uftc8inx 996 12 are be VBP cord-010092-uftc8inx 996 13 available available JJ cord-010092-uftc8inx 996 14 . . . cord-010092-uftc8inx 997 1 The the DT cord-010092-uftc8inx 997 2 aim aim NN cord-010092-uftc8inx 997 3 of of IN cord-010092-uftc8inx 997 4 this this DT cord-010092-uftc8inx 997 5 study study NN cord-010092-uftc8inx 997 6 was be VBD cord-010092-uftc8inx 997 7 to to TO cord-010092-uftc8inx 997 8 analyse analyse VB cord-010092-uftc8inx 997 9 this this DT cord-010092-uftc8inx 997 10 marker marker NN cord-010092-uftc8inx 997 11 in in IN cord-010092-uftc8inx 997 12 our -PRON- PRP$ cord-010092-uftc8inx 997 13 cohort cohort NN cord-010092-uftc8inx 997 14 of of IN cord-010092-uftc8inx 997 15 OBI OBI NNP cord-010092-uftc8inx 997 16 blood blood NN cord-010092-uftc8inx 997 17 donors donor NNS cord-010092-uftc8inx 997 18 . . . cord-010092-uftc8inx 998 1 Methods method NNS cord-010092-uftc8inx 998 2 : : : cord-010092-uftc8inx 999 1 HBcrAg HBcrAg NNP cord-010092-uftc8inx 999 2 was be VBD cord-010092-uftc8inx 999 3 measured measure VBN cord-010092-uftc8inx 999 4 in in IN cord-010092-uftc8inx 999 5 69 69 CD cord-010092-uftc8inx 999 6 blood blood NN cord-010092-uftc8inx 999 7 donors donor NNS cord-010092-uftc8inx 999 8 confirmed confirm VBD cord-010092-uftc8inx 999 9 to to TO cord-010092-uftc8inx 999 10 be be VB cord-010092-uftc8inx 999 11 carriers carrier NNS cord-010092-uftc8inx 999 12 of of IN cord-010092-uftc8inx 999 13 OBI OBI NNP cord-010092-uftc8inx 999 14 ( ( -LRB- cord-010092-uftc8inx 999 15 HBsAg- HBsAg- NNP cord-010092-uftc8inx 999 16 , , , cord-010092-uftc8inx 999 17 HBV HBV NNP cord-010092-uftc8inx 999 18 DNA+ DNA+ NNP cord-010092-uftc8inx 999 19 ) ) -RRB- cord-010092-uftc8inx 999 20 . . . cord-010092-uftc8inx 1000 1 Of of IN cord-010092-uftc8inx 1000 2 them -PRON- PRP cord-010092-uftc8inx 1000 3 , , , cord-010092-uftc8inx 1000 4 59/69 59/69 CD cord-010092-uftc8inx 1000 5 ( ( -LRB- cord-010092-uftc8inx 1000 6 85.5 85.5 CD cord-010092-uftc8inx 1000 7 % % NN cord-010092-uftc8inx 1000 8 ) ) -RRB- cord-010092-uftc8inx 1000 9 donors donor NNS cord-010092-uftc8inx 1000 10 were be VBD cord-010092-uftc8inx 1000 11 anti anti JJ cord-010092-uftc8inx 1000 12 - - JJ cord-010092-uftc8inx 1000 13 HBc hbc JJ cord-010092-uftc8inx 1000 14 positive positive JJ cord-010092-uftc8inx 1000 15 , , , cord-010092-uftc8inx 1000 16 and and CC cord-010092-uftc8inx 1000 17 10 10 CD cord-010092-uftc8inx 1000 18 ( ( -LRB- cord-010092-uftc8inx 1000 19 14.5 14.5 CD cord-010092-uftc8inx 1000 20 % % NN cord-010092-uftc8inx 1000 21 ) ) -RRB- cord-010092-uftc8inx 1000 22 negative negative JJ cord-010092-uftc8inx 1000 23 . . . cord-010092-uftc8inx 1001 1 18 18 CD cord-010092-uftc8inx 1001 2 donors donor NNS cord-010092-uftc8inx 1001 3 had have VBD cord-010092-uftc8inx 1001 4 both both DT cord-010092-uftc8inx 1001 5 anti anti JJ cord-010092-uftc8inx 1001 6 - - JJ cord-010092-uftc8inx 1001 7 HBc hbc JJ cord-010092-uftc8inx 1001 8 and and CC cord-010092-uftc8inx 1001 9 anti anti JJ cord-010092-uftc8inx 1001 10 - - JJ cord-010092-uftc8inx 1001 11 HBe hbe JJ cord-010092-uftc8inx 1001 12 reactivities reactivity NNS cord-010092-uftc8inx 1001 13 . . . cord-010092-uftc8inx 1002 1 A a DT cord-010092-uftc8inx 1002 2 group group NN cord-010092-uftc8inx 1002 3 of of IN cord-010092-uftc8inx 1002 4 11 11 CD cord-010092-uftc8inx 1002 5 young young JJ cord-010092-uftc8inx 1002 6 blood blood NN cord-010092-uftc8inx 1002 7 donors donor NNS cord-010092-uftc8inx 1002 8 vaccinated vaccinate VBN cord-010092-uftc8inx 1002 9 for for IN cord-010092-uftc8inx 1002 10 HBV HBV NNP cord-010092-uftc8inx 1002 11 infection infection NN cord-010092-uftc8inx 1002 12 ( ( -LRB- cord-010092-uftc8inx 1002 13 HBsAg- hbsag- CD cord-010092-uftc8inx 1002 14 , , , cord-010092-uftc8inx 1002 15 HBV HBV NNP cord-010092-uftc8inx 1002 16 DNA- DNA- NNP cord-010092-uftc8inx 1002 17 , , , cord-010092-uftc8inx 1002 18 anti anti JJ cord-010092-uftc8inx 1002 19 - - JJ cord-010092-uftc8inx 1002 20 HBc- HBc- NNP cord-010092-uftc8inx 1002 21 ) ) -RRB- cord-010092-uftc8inx 1002 22 , , , cord-010092-uftc8inx 1002 23 and and CC cord-010092-uftc8inx 1002 24 9 9 CD cord-010092-uftc8inx 1002 25 patients patient NNS cord-010092-uftc8inx 1002 26 with with IN cord-010092-uftc8inx 1002 27 chronic chronic JJ cord-010092-uftc8inx 1002 28 HBV HBV NNP cord-010092-uftc8inx 1002 29 infection infection NN cord-010092-uftc8inx 1002 30 ( ( -LRB- cord-010092-uftc8inx 1002 31 HBsAg+ hbsag+ NN cord-010092-uftc8inx 1002 32 , , , cord-010092-uftc8inx 1002 33 HBV HBV NNP cord-010092-uftc8inx 1002 34 DNA+ DNA+ NNP cord-010092-uftc8inx 1002 35 ) ) -RRB- cord-010092-uftc8inx 1002 36 were be VBD cord-010092-uftc8inx 1002 37 used use VBN cord-010092-uftc8inx 1002 38 as as IN cord-010092-uftc8inx 1002 39 negative negative JJ cord-010092-uftc8inx 1002 40 and and CC cord-010092-uftc8inx 1002 41 positive positive JJ cord-010092-uftc8inx 1002 42 controls control NNS cord-010092-uftc8inx 1002 43 group group NN cord-010092-uftc8inx 1002 44 , , , cord-010092-uftc8inx 1002 45 respectively respectively RB cord-010092-uftc8inx 1002 46 . . . cord-010092-uftc8inx 1003 1 Serum serum NN cord-010092-uftc8inx 1003 2 HBcrAg HBcrAg NNP cord-010092-uftc8inx 1003 3 was be VBD cord-010092-uftc8inx 1003 4 measured measure VBN cord-010092-uftc8inx 1003 5 using use VBG cord-010092-uftc8inx 1003 6 a a DT cord-010092-uftc8inx 1003 7 chemiluminescent chemiluminescent NN cord-010092-uftc8inx 1003 8 enzyme enzyme NN cord-010092-uftc8inx 1003 9 immunoassay immunoassay NN cord-010092-uftc8inx 1003 10 on on IN cord-010092-uftc8inx 1003 11 the the DT cord-010092-uftc8inx 1003 12 Lumipulse Lumipulse NNP cord-010092-uftc8inx 1003 13 G600 G600 NNP cord-010092-uftc8inx 1003 14 automated automate VBD cord-010092-uftc8inx 1003 15 analyzer analyzer NN cord-010092-uftc8inx 1003 16 ( ( -LRB- cord-010092-uftc8inx 1003 17 Fujirebio Fujirebio NNP cord-010092-uftc8inx 1003 18 , , , cord-010092-uftc8inx 1003 19 Tokyo Tokyo NNP cord-010092-uftc8inx 1003 20 , , , cord-010092-uftc8inx 1003 21 Japan Japan NNP cord-010092-uftc8inx 1003 22 ) ) -RRB- cord-010092-uftc8inx 1003 23 . . . cord-010092-uftc8inx 1004 1 The the DT cord-010092-uftc8inx 1004 2 lower low JJR cord-010092-uftc8inx 1004 3 limit limit NN cord-010092-uftc8inx 1004 4 of of IN cord-010092-uftc8inx 1004 5 detection detection NN cord-010092-uftc8inx 1004 6 ( ( -LRB- cord-010092-uftc8inx 1004 7 LOD lod NN cord-010092-uftc8inx 1004 8 ) ) -RRB- cord-010092-uftc8inx 1004 9 of of IN cord-010092-uftc8inx 1004 10 the the DT cord-010092-uftc8inx 1004 11 quantitative quantitative JJ cord-010092-uftc8inx 1004 12 assay assay NN cord-010092-uftc8inx 1004 13 is be VBZ cord-010092-uftc8inx 1005 1 2 2 LS cord-010092-uftc8inx 1005 2 logU logu NN cord-010092-uftc8inx 1005 3 / / SYM cord-010092-uftc8inx 1005 4 ml ml NN cord-010092-uftc8inx 1005 5 and and CC cord-010092-uftc8inx 1005 6 the the DT cord-010092-uftc8inx 1005 7 lower low JJR cord-010092-uftc8inx 1005 8 limit limit NN cord-010092-uftc8inx 1005 9 of of IN cord-010092-uftc8inx 1005 10 quantification quantification NN cord-010092-uftc8inx 1005 11 ( ( -LRB- cord-010092-uftc8inx 1005 12 LOQ LOQ NNP cord-010092-uftc8inx 1005 13 ) ) -RRB- cord-010092-uftc8inx 1005 14 is be VBZ cord-010092-uftc8inx 1005 15 > > XX cord-010092-uftc8inx 1005 16 3 3 CD cord-010092-uftc8inx 1005 17 logU logu NN cord-010092-uftc8inx 1005 18 / / SYM cord-010092-uftc8inx 1005 19 ml ml NNS cord-010092-uftc8inx 1005 20 , , , cord-010092-uftc8inx 1005 21 due due IN cord-010092-uftc8inx 1005 22 to to IN cord-010092-uftc8inx 1005 23 nonlinearity nonlinearity NN cord-010092-uftc8inx 1005 24 results result NNS cord-010092-uftc8inx 1005 25 between between IN cord-010092-uftc8inx 1005 26 2 2 CD cord-010092-uftc8inx 1005 27 and and CC cord-010092-uftc8inx 1005 28 3 3 CD cord-010092-uftc8inx 1005 29 logU logu NN cord-010092-uftc8inx 1005 30 / / SYM cord-010092-uftc8inx 1005 31 ml ml NN cord-010092-uftc8inx 1005 32 . . . cord-010092-uftc8inx 1006 1 Levels level NNS cord-010092-uftc8inx 1006 2 of of IN cord-010092-uftc8inx 1006 3 HBcrAg HBcrAg NNP cord-010092-uftc8inx 1006 4 were be VBD cord-010092-uftc8inx 1006 5 tested test VBN cord-010092-uftc8inx 1006 6 in in IN cord-010092-uftc8inx 1006 7 the the DT cord-010092-uftc8inx 1006 8 three three CD cord-010092-uftc8inx 1006 9 groups group NNS cord-010092-uftc8inx 1006 10 and and CC cord-010092-uftc8inx 1006 11 analysed analyse VBD cord-010092-uftc8inx 1006 12 in in IN cord-010092-uftc8inx 1006 13 comparison comparison NN cord-010092-uftc8inx 1006 14 to to IN cord-010092-uftc8inx 1006 15 the the DT cord-010092-uftc8inx 1006 16 presence presence NN cord-010092-uftc8inx 1006 17 of of IN cord-010092-uftc8inx 1006 18 anti anti JJ cord-010092-uftc8inx 1006 19 - - JJ cord-010092-uftc8inx 1006 20 HBc hbc JJ cord-010092-uftc8inx 1006 21 and and CC cord-010092-uftc8inx 1006 22 anti anti JJ cord-010092-uftc8inx 1006 23 - - JJ cord-010092-uftc8inx 1006 24 HBe hbe JJ cord-010092-uftc8inx 1006 25 . . . cord-010092-uftc8inx 1007 1 Statistical statistical JJ cord-010092-uftc8inx 1007 2 analysis analysis NN cord-010092-uftc8inx 1007 3 was be VBD cord-010092-uftc8inx 1007 4 performed perform VBN cord-010092-uftc8inx 1007 5 by by IN cord-010092-uftc8inx 1007 6 the the DT cord-010092-uftc8inx 1007 7 IBM IBM NNP cord-010092-uftc8inx 1007 8 Statistics Statistics NNPS cord-010092-uftc8inx 1007 9 SPSS SPSS NNP cord-010092-uftc8inx 1007 10 19.0.0 19.0.0 CD cord-010092-uftc8inx 1007 11 . . . cord-010092-uftc8inx 1008 1 Results result NNS cord-010092-uftc8inx 1008 2 : : : cord-010092-uftc8inx 1009 1 All all DT cord-010092-uftc8inx 1009 2 donors donor NNS cord-010092-uftc8inx 1009 3 in in IN cord-010092-uftc8inx 1009 4 the the DT cord-010092-uftc8inx 1009 5 negative negative JJ cord-010092-uftc8inx 1009 6 control control NN cord-010092-uftc8inx 1009 7 group group NN cord-010092-uftc8inx 1009 8 had have VBD cord-010092-uftc8inx 1009 9 undetectable undetectable JJ cord-010092-uftc8inx 1009 10 HBcrAg HBcrAg NNP cord-010092-uftc8inx 1009 11 levels level NNS cord-010092-uftc8inx 1009 12 , , , cord-010092-uftc8inx 1009 13 whereas whereas IN cord-010092-uftc8inx 1009 14 all all DT cord-010092-uftc8inx 1009 15 patients patient NNS cord-010092-uftc8inx 1009 16 in in IN cord-010092-uftc8inx 1009 17 the the DT cord-010092-uftc8inx 1009 18 positive positive JJ cord-010092-uftc8inx 1009 19 control control NN cord-010092-uftc8inx 1009 20 group group NN cord-010092-uftc8inx 1009 21 have have VBP cord-010092-uftc8inx 1009 22 detectable detectable JJ cord-010092-uftc8inx 1009 23 HBcrAg HBcrAg NNP cord-010092-uftc8inx 1010 1 ( ( -LRB- cord-010092-uftc8inx 1010 2 mean mean JJ cord-010092-uftc8inx 1010 3 value value NN cord-010092-uftc8inx 1010 4 : : : cord-010092-uftc8inx 1010 5 3.0 3.0 CD cord-010092-uftc8inx 1010 6 logU logu NN cord-010092-uftc8inx 1010 7 / / SYM cord-010092-uftc8inx 1010 8 ml ml NN cord-010092-uftc8inx 1010 9 , , , cord-010092-uftc8inx 1010 10 range range NNP cord-010092-uftc8inx 1010 11 2.0 2.0 CD cord-010092-uftc8inx 1010 12 - - HYPH cord-010092-uftc8inx 1010 13 4.9 4.9 CD cord-010092-uftc8inx 1010 14 ) ) -RRB- cord-010092-uftc8inx 1010 15 , , , cord-010092-uftc8inx 1010 16 confirming confirm VBG cord-010092-uftc8inx 1010 17 that that IN cord-010092-uftc8inx 1010 18 individuals individual NNS cord-010092-uftc8inx 1010 19 without without IN cord-010092-uftc8inx 1010 20 prior prior JJ cord-010092-uftc8inx 1010 21 exposure exposure NN cord-010092-uftc8inx 1010 22 to to IN cord-010092-uftc8inx 1010 23 HBV HBV NNP cord-010092-uftc8inx 1010 24 would would MD cord-010092-uftc8inx 1010 25 not not RB cord-010092-uftc8inx 1010 26 have have VB cord-010092-uftc8inx 1010 27 detectable detectable JJ cord-010092-uftc8inx 1010 28 HBcrAg HBcrAg NNP cord-010092-uftc8inx 1010 29 . . . cord-010092-uftc8inx 1011 1 HBcrAg HBcrAg NNP cord-010092-uftc8inx 1011 2 was be VBD cord-010092-uftc8inx 1011 3 detectable detectable JJ cord-010092-uftc8inx 1011 4 in in IN cord-010092-uftc8inx 1011 5 34/69 34/69 CD cord-010092-uftc8inx 1011 6 OBI OBI NNP cord-010092-uftc8inx 1011 7 donors donor NNS cord-010092-uftc8inx 1011 8 ( ( -LRB- cord-010092-uftc8inx 1011 9 49.3 49.3 CD cord-010092-uftc8inx 1011 10 % % NN cord-010092-uftc8inx 1011 11 ) ) -RRB- cord-010092-uftc8inx 1011 12 , , , cord-010092-uftc8inx 1011 13 with with IN cord-010092-uftc8inx 1011 14 a a DT cord-010092-uftc8inx 1011 15 mean mean JJ cord-010092-uftc8inx 1011 16 value value NN cord-010092-uftc8inx 1011 17 of of IN cord-010092-uftc8inx 1011 18 2.21 2.21 CD cord-010092-uftc8inx 1011 19 logU logU NNS cord-010092-uftc8inx 1011 20 / / SYM cord-010092-uftc8inx 1011 21 ml ml NN cord-010092-uftc8inx 1011 22 ( ( -LRB- cord-010092-uftc8inx 1011 23 range range NNP cord-010092-uftc8inx 1011 24 2.0 2.0 CD cord-010092-uftc8inx 1011 25 - - HYPH cord-010092-uftc8inx 1011 26 3.20 3.20 CD cord-010092-uftc8inx 1011 27 ) ) -RRB- cord-010092-uftc8inx 1011 28 . . . cord-010092-uftc8inx 1012 1 HBcrAg HBcrAg NNP cord-010092-uftc8inx 1012 2 could could MD cord-010092-uftc8inx 1012 3 be be VB cord-010092-uftc8inx 1012 4 measured measure VBN cord-010092-uftc8inx 1012 5 only only RB cord-010092-uftc8inx 1012 6 in in IN cord-010092-uftc8inx 1012 7 2 2 CD cord-010092-uftc8inx 1012 8 OBI OBI NNP cord-010092-uftc8inx 1012 9 donors donor NNS cord-010092-uftc8inx 1012 10 ( ( -LRB- cord-010092-uftc8inx 1012 11 3.0 3.0 CD cord-010092-uftc8inx 1012 12 and and CC cord-010092-uftc8inx 1012 13 3.2 3.2 CD cord-010092-uftc8inx 1012 14 logU logu NN cord-010092-uftc8inx 1012 15 / / SYM cord-010092-uftc8inx 1012 16 ml ml NN cord-010092-uftc8inx 1012 17 ) ) -RRB- cord-010092-uftc8inx 1012 18 , , , cord-010092-uftc8inx 1012 19 being be VBG cord-010092-uftc8inx 1012 20 below below IN cord-010092-uftc8inx 1012 21 the the DT cord-010092-uftc8inx 1012 22 LOQ loq NN cord-010092-uftc8inx 1012 23 of of IN cord-010092-uftc8inx 1012 24 the the DT cord-010092-uftc8inx 1012 25 test test NN cord-010092-uftc8inx 1012 26 in in IN cord-010092-uftc8inx 1012 27 the the DT cord-010092-uftc8inx 1012 28 majority majority NN cord-010092-uftc8inx 1012 29 of of IN cord-010092-uftc8inx 1012 30 OBI OBI NNP cord-010092-uftc8inx 1012 31 ( ( -LRB- cord-010092-uftc8inx 1012 32 32/34 32/34 CD cord-010092-uftc8inx 1012 33 ) ) -RRB- cord-010092-uftc8inx 1012 34 . . . cord-010092-uftc8inx 1013 1 Considering consider VBG cord-010092-uftc8inx 1013 2 the the DT cord-010092-uftc8inx 1013 3 presence presence NN cord-010092-uftc8inx 1013 4 of of IN cord-010092-uftc8inx 1013 5 anti anti JJ cord-010092-uftc8inx 1013 6 - - JJ cord-010092-uftc8inx 1013 7 HBc HBc NNP cord-010092-uftc8inx 1013 8 , , , cord-010092-uftc8inx 1013 9 HBcrAg HBcrAg NNP cord-010092-uftc8inx 1013 10 was be VBD cord-010092-uftc8inx 1013 11 detected detect VBN cord-010092-uftc8inx 1013 12 in in IN cord-010092-uftc8inx 1013 13 29/59 29/59 CD cord-010092-uftc8inx 1013 14 ( ( -LRB- cord-010092-uftc8inx 1013 15 49.1 49.1 CD cord-010092-uftc8inx 1013 16 % % NN cord-010092-uftc8inx 1013 17 ) ) -RRB- cord-010092-uftc8inx 1013 18 anti anti NNS cord-010092-uftc8inx 1013 19 - - JJ cord-010092-uftc8inx 1013 20 HBc+ hbc+ JJ cord-010092-uftc8inx 1013 21 and and CC cord-010092-uftc8inx 1013 22 in in IN cord-010092-uftc8inx 1013 23 5/10 5/10 CD cord-010092-uftc8inx 1013 24 ( ( -LRB- cord-010092-uftc8inx 1013 25 50 50 CD cord-010092-uftc8inx 1013 26 % % NN cord-010092-uftc8inx 1013 27 ) ) -RRB- cord-010092-uftc8inx 1014 1 anti anti JJ cord-010092-uftc8inx 1014 2 - - JJ cord-010092-uftc8inx 1014 3 HBc hbc JJ cord-010092-uftc8inx 1014 4 - - HYPH cord-010092-uftc8inx 1014 5 OBI OBI NNP cord-010092-uftc8inx 1014 6 , , , cord-010092-uftc8inx 1014 7 with with IN cord-010092-uftc8inx 1014 8 no no DT cord-010092-uftc8inx 1014 9 significant significant JJ cord-010092-uftc8inx 1014 10 difference difference NN cord-010092-uftc8inx 1014 11 in in IN cord-010092-uftc8inx 1014 12 their -PRON- PRP$ cord-010092-uftc8inx 1014 13 mean mean JJ cord-010092-uftc8inx 1014 14 levels level NNS cord-010092-uftc8inx 1014 15 ( ( -LRB- cord-010092-uftc8inx 1014 16 2.21 2.21 CD cord-010092-uftc8inx 1014 17 AE AE NNP cord-010092-uftc8inx 1014 18 0.32 0.32 CD cord-010092-uftc8inx 1014 19 vs vs IN cord-010092-uftc8inx 1014 20 2.14 2.14 CD cord-010092-uftc8inx 1014 21 AE AE NNP cord-010092-uftc8inx 1014 22 0.26 0.26 CD cord-010092-uftc8inx 1014 23 ; ; : cord-010092-uftc8inx 1014 24 P p NN cord-010092-uftc8inx 1014 25 = = SYM cord-010092-uftc8inx 1014 26 0.44 0.44 CD cord-010092-uftc8inx 1014 27 ) ) -RRB- cord-010092-uftc8inx 1014 28 . . . cord-010092-uftc8inx 1015 1 Interestingly interestingly RB cord-010092-uftc8inx 1015 2 , , , cord-010092-uftc8inx 1015 3 the the DT cord-010092-uftc8inx 1015 4 presence presence NN cord-010092-uftc8inx 1015 5 of of IN cord-010092-uftc8inx 1015 6 anti anti JJ cord-010092-uftc8inx 1015 7 - - JJ cord-010092-uftc8inx 1015 8 HBe hbe JJ cord-010092-uftc8inx 1015 9 ( ( -LRB- cord-010092-uftc8inx 1015 10 18/62 18/62 CD cord-010092-uftc8inx 1015 11 ) ) -RRB- cord-010092-uftc8inx 1015 12 was be VBD cord-010092-uftc8inx 1015 13 independently independently RB cord-010092-uftc8inx 1015 14 associated associate VBN cord-010092-uftc8inx 1015 15 with with IN cord-010092-uftc8inx 1015 16 higher high JJR cord-010092-uftc8inx 1015 17 HBcrAg HBcrAg NNP cord-010092-uftc8inx 1015 18 levels level NNS cord-010092-uftc8inx 1015 19 ( ( -LRB- cord-010092-uftc8inx 1015 20 2.38 2.38 CD cord-010092-uftc8inx 1015 21 AE AE NNP cord-010092-uftc8inx 1015 22 0.42 0.42 CD cord-010092-uftc8inx 1015 23 vs vs IN cord-010092-uftc8inx 1015 24 2.14 2.14 CD cord-010092-uftc8inx 1015 25 AE AE NNP cord-010092-uftc8inx 1015 26 0.22 0.22 CD cord-010092-uftc8inx 1015 27 ; ; : cord-010092-uftc8inx 1015 28 P p NN cord-010092-uftc8inx 1015 29 = = SYM cord-010092-uftc8inx 1015 30 0.03 0.03 CD cord-010092-uftc8inx 1015 31 ) ) -RRB- cord-010092-uftc8inx 1015 32 . . . cord-010092-uftc8inx 1016 1 Summary Summary NNP cord-010092-uftc8inx 1016 2 / / SYM cord-010092-uftc8inx 1016 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 1016 4 : : : cord-010092-uftc8inx 1017 1 Identification identification NN cord-010092-uftc8inx 1017 2 of of IN cord-010092-uftc8inx 1017 3 donors donor NNS cord-010092-uftc8inx 1017 4 with with IN cord-010092-uftc8inx 1017 5 OBI OBI NNP cord-010092-uftc8inx 1017 6 is be VBZ cord-010092-uftc8inx 1017 7 critical critical JJ cord-010092-uftc8inx 1017 8 to to TO cord-010092-uftc8inx 1017 9 prevent prevent VB cord-010092-uftc8inx 1017 10 the the DT cord-010092-uftc8inx 1017 11 risk risk NN cord-010092-uftc8inx 1017 12 of of IN cord-010092-uftc8inx 1017 13 HBV HBV NNP cord-010092-uftc8inx 1017 14 transfusion transfusion NN cord-010092-uftc8inx 1017 15 - - HYPH cord-010092-uftc8inx 1017 16 transmission transmission NN cord-010092-uftc8inx 1017 17 . . . cord-010092-uftc8inx 1018 1 Being be VBG cord-010092-uftc8inx 1018 2 HBcrAg HBcrAg NNP cord-010092-uftc8inx 1018 3 associated associate VBN cord-010092-uftc8inx 1018 4 with with IN cord-010092-uftc8inx 1018 5 the the DT cord-010092-uftc8inx 1018 6 cccDNA cccdna NN cord-010092-uftc8inx 1018 7 content content NN cord-010092-uftc8inx 1018 8 and and CC cord-010092-uftc8inx 1018 9 replication replication NN cord-010092-uftc8inx 1018 10 , , , cord-010092-uftc8inx 1018 11 our -PRON- PRP$ cord-010092-uftc8inx 1018 12 results result NNS cord-010092-uftc8inx 1018 13 suggest suggest VBP cord-010092-uftc8inx 1018 14 that that IN cord-010092-uftc8inx 1018 15 the the DT cord-010092-uftc8inx 1018 16 presence presence NN cord-010092-uftc8inx 1018 17 of of IN cord-010092-uftc8inx 1018 18 HBcrAg HBcrAg NNP cord-010092-uftc8inx 1018 19 , , , cord-010092-uftc8inx 1018 20 even even RB cord-010092-uftc8inx 1018 21 if if IN cord-010092-uftc8inx 1018 22 not not RB cord-010092-uftc8inx 1018 23 quantifiable quantifiable JJ cord-010092-uftc8inx 1018 24 , , , cord-010092-uftc8inx 1018 25 could could MD cord-010092-uftc8inx 1018 26 be be VB cord-010092-uftc8inx 1018 27 useful useful JJ cord-010092-uftc8inx 1018 28 marker marker NN cord-010092-uftc8inx 1018 29 to to TO cord-010092-uftc8inx 1018 30 confirm confirm VB cord-010092-uftc8inx 1018 31 the the DT cord-010092-uftc8inx 1018 32 occult occult JJ cord-010092-uftc8inx 1018 33 infection infection NN cord-010092-uftc8inx 1018 34 status status NN cord-010092-uftc8inx 1018 35 , , , cord-010092-uftc8inx 1018 36 even even RB cord-010092-uftc8inx 1018 37 in in IN cord-010092-uftc8inx 1018 38 anti anti JJ cord-010092-uftc8inx 1018 39 - - JJ cord-010092-uftc8inx 1018 40 HBc hbc JJ cord-010092-uftc8inx 1018 41 negative negative JJ cord-010092-uftc8inx 1018 42 donors donor NNS cord-010092-uftc8inx 1018 43 . . . cord-010092-uftc8inx 1019 1 The the DT cord-010092-uftc8inx 1019 2 association association NN cord-010092-uftc8inx 1019 3 between between IN cord-010092-uftc8inx 1019 4 HBcrAg HBcrAg NNP cord-010092-uftc8inx 1019 5 , , , cord-010092-uftc8inx 1019 6 anti anti JJ cord-010092-uftc8inx 1019 7 - - JJ cord-010092-uftc8inx 1019 8 HBc hbc JJ cord-010092-uftc8inx 1019 9 and and CC cord-010092-uftc8inx 1019 10 anti anti JJ cord-010092-uftc8inx 1019 11 - - NNS cord-010092-uftc8inx 1019 12 HBe hbe JJ cord-010092-uftc8inx 1019 13 could could MD cord-010092-uftc8inx 1019 14 also also RB cord-010092-uftc8inx 1019 15 be be VB cord-010092-uftc8inx 1019 16 a a DT cord-010092-uftc8inx 1019 17 useful useful JJ cord-010092-uftc8inx 1019 18 marker marker NN cord-010092-uftc8inx 1019 19 to to TO cord-010092-uftc8inx 1019 20 identify identify VB cord-010092-uftc8inx 1019 21 OBI OBI NNP cord-010092-uftc8inx 1019 22 donors donor NNS cord-010092-uftc8inx 1019 23 with with IN cord-010092-uftc8inx 1019 24 a a DT cord-010092-uftc8inx 1019 25 higher high JJR cord-010092-uftc8inx 1019 26 risk risk NN cord-010092-uftc8inx 1019 27 of of IN cord-010092-uftc8inx 1019 28 HBV HBV NNP cord-010092-uftc8inx 1019 29 reactivation reactivation NN cord-010092-uftc8inx 1019 30 . . . cord-010092-uftc8inx 1020 1 3C 3C NNP cord-010092-uftc8inx 1020 2 - - HYPH cord-010092-uftc8inx 1020 3 S08 S08 NNP cord-010092-uftc8inx 1020 4 - - HYPH cord-010092-uftc8inx 1020 5 05 05 CD cord-010092-uftc8inx 1020 6 HC HC NNP cord-010092-uftc8inx 1020 7 group group NN cord-010092-uftc8inx 1020 8 . . . cord-010092-uftc8inx 1021 1 Human human JJ cord-010092-uftc8inx 1021 2 peripheral peripheral JJ cord-010092-uftc8inx 1021 3 blood blood NN cord-010092-uftc8inx 1021 4 mononuclear mononuclear NN cord-010092-uftc8inx 1021 5 cells cell NNS cord-010092-uftc8inx 1021 6 ( ( -LRB- cord-010092-uftc8inx 1021 7 PBMCs pbmc NNS cord-010092-uftc8inx 1021 8 ) ) -RRB- cord-010092-uftc8inx 1021 9 from from IN cord-010092-uftc8inx 1021 10 blood blood NN cord-010092-uftc8inx 1021 11 donors donor NNS cord-010092-uftc8inx 1021 12 were be VBD cord-010092-uftc8inx 1021 13 stimulated stimulate VBN cord-010092-uftc8inx 1021 14 with with IN cord-010092-uftc8inx 1021 15 HBV HBV NNP cord-010092-uftc8inx 1021 16 polypeptides polypeptide NNS cord-010092-uftc8inx 1021 17 pool pool VBP cord-010092-uftc8inx 1021 18 in in IN cord-010092-uftc8inx 1021 19 vitro vitro FW cord-010092-uftc8inx 1021 20 . . . cord-010092-uftc8inx 1022 1 T T NNP cord-010092-uftc8inx 1022 2 cell cell NN cord-010092-uftc8inx 1022 3 proliferation proliferation NN cord-010092-uftc8inx 1022 4 assays assay NNS cord-010092-uftc8inx 1022 5 ( ( -LRB- cord-010092-uftc8inx 1022 6 CFSE CFSE NNP cord-010092-uftc8inx 1022 7 ) ) -RRB- cord-010092-uftc8inx 1022 8 was be VBD cord-010092-uftc8inx 1022 9 used use VBN cord-010092-uftc8inx 1022 10 to to IN cord-010092-uftc8inx 1022 11 detecting detect VBG cord-010092-uftc8inx 1022 12 T t NN cord-010092-uftc8inx 1022 13 cell cell NN cord-010092-uftc8inx 1022 14 proliferation proliferation NN cord-010092-uftc8inx 1022 15 , , , cord-010092-uftc8inx 1022 16 enzyme enzyme NN cord-010092-uftc8inx 1022 17 - - HYPH cord-010092-uftc8inx 1022 18 linked link VBN cord-010092-uftc8inx 1022 19 immunospot immunospot NN cord-010092-uftc8inx 1022 20 assay assay NN cord-010092-uftc8inx 1022 21 ( ( -LRB- cord-010092-uftc8inx 1022 22 ELISPOT ELISPOT NNP cord-010092-uftc8inx 1022 23 ) ) -RRB- cord-010092-uftc8inx 1022 24 was be VBD cord-010092-uftc8inx 1022 25 used use VBN cord-010092-uftc8inx 1022 26 to to IN cord-010092-uftc8inx 1022 27 detecting detect VBG cord-010092-uftc8inx 1022 28 the the DT cord-010092-uftc8inx 1022 29 frequency frequency NN cord-010092-uftc8inx 1022 30 of of IN cord-010092-uftc8inx 1022 31 HBV HBV NNP cord-010092-uftc8inx 1022 32 - - HYPH cord-010092-uftc8inx 1022 33 specific specific JJ cord-010092-uftc8inx 1022 34 IFN IFN NNP cord-010092-uftc8inx 1022 35 - - HYPH cord-010092-uftc8inx 1022 36 c c NNP cord-010092-uftc8inx 1022 37 secreted secrete VBD cord-010092-uftc8inx 1022 38 T T NNP cord-010092-uftc8inx 1022 39 cells cell NNS cord-010092-uftc8inx 1022 40 . . . cord-010092-uftc8inx 1023 1 SPSS SPSS NNP cord-010092-uftc8inx 1023 2 20.0 20.0 CD cord-010092-uftc8inx 1023 3 statistical statistical JJ cord-010092-uftc8inx 1023 4 analysis analysis NN cord-010092-uftc8inx 1023 5 software software NN cord-010092-uftc8inx 1023 6 was be VBD cord-010092-uftc8inx 1023 7 used use VBN cord-010092-uftc8inx 1023 8 for for IN cord-010092-uftc8inx 1023 9 statistical statistical JJ cord-010092-uftc8inx 1023 10 analysis analysis NN cord-010092-uftc8inx 1023 11 . . . cord-010092-uftc8inx 1024 1 The the DT cord-010092-uftc8inx 1024 2 measurement measurement NN cord-010092-uftc8inx 1024 3 data datum NNS cord-010092-uftc8inx 1024 4 of of IN cord-010092-uftc8inx 1024 5 normal normal JJ cord-010092-uftc8inx 1024 6 distribution distribution NN cord-010092-uftc8inx 1024 7 were be VBD cord-010092-uftc8inx 1024 8 tested test VBN cord-010092-uftc8inx 1024 9 by by IN cord-010092-uftc8inx 1024 10 two two CD cord-010092-uftc8inx 1024 11 independent independent JJ cord-010092-uftc8inx 1024 12 samples sample NNS cord-010092-uftc8inx 1024 13 t t NN cord-010092-uftc8inx 1024 14 test test NN cord-010092-uftc8inx 1024 15 ; ; : cord-010092-uftc8inx 1024 16 and and CC cord-010092-uftc8inx 1024 17 the the DT cord-010092-uftc8inx 1024 18 comparison comparison NN cord-010092-uftc8inx 1024 19 between between IN cord-010092-uftc8inx 1024 20 multiple multiple JJ cord-010092-uftc8inx 1024 21 groups group NNS cord-010092-uftc8inx 1024 22 was be VBD cord-010092-uftc8inx 1024 23 analyzed analyze VBN cord-010092-uftc8inx 1024 24 by by IN cord-010092-uftc8inx 1024 25 one one CD cord-010092-uftc8inx 1024 26 - - HYPH cord-010092-uftc8inx 1024 27 way way NN cord-010092-uftc8inx 1024 28 ANOVA ANOVA NNP cord-010092-uftc8inx 1024 29 . . . cord-010092-uftc8inx 1025 1 Mann Mann NNP cord-010092-uftc8inx 1025 2 - - HYPH cord-010092-uftc8inx 1025 3 Whitney Whitney NNP cord-010092-uftc8inx 1025 4 U U NNP cord-010092-uftc8inx 1025 5 test test NN cord-010092-uftc8inx 1025 6 was be VBD cord-010092-uftc8inx 1025 7 used use VBN cord-010092-uftc8inx 1025 8 for for IN cord-010092-uftc8inx 1025 9 comparison comparison NN cord-010092-uftc8inx 1025 10 between between IN cord-010092-uftc8inx 1025 11 non non JJ cord-010092-uftc8inx 1025 12 - - JJ cord-010092-uftc8inx 1025 13 normal normal JJ cord-010092-uftc8inx 1025 14 data data NN cord-010092-uftc8inx 1025 15 sets set NNS cord-010092-uftc8inx 1025 16 . . . cord-010092-uftc8inx 1026 1 P p NN cord-010092-uftc8inx 1026 2 < < XX cord-010092-uftc8inx 1026 3 0.05 0.05 CD cord-010092-uftc8inx 1026 4 was be VBD cord-010092-uftc8inx 1026 5 considered consider VBN cord-010092-uftc8inx 1026 6 statistically statistically RB cord-010092-uftc8inx 1026 7 significant significant JJ cord-010092-uftc8inx 1026 8 . . . cord-010092-uftc8inx 1027 1 Results result NNS cord-010092-uftc8inx 1027 2 : : : cord-010092-uftc8inx 1027 3 1 1 CD cord-010092-uftc8inx 1027 4 . . . cord-010092-uftc8inx 1028 1 Proliferation proliferation NN cord-010092-uftc8inx 1028 2 characteristics characteristic NNS cord-010092-uftc8inx 1028 3 of of IN cord-010092-uftc8inx 1028 4 T t NN cord-010092-uftc8inx 1028 5 cells cell NNS cord-010092-uftc8inx 1028 6 . . . cord-010092-uftc8inx 1029 1 The the DT cord-010092-uftc8inx 1029 2 proliferation proliferation NN cord-010092-uftc8inx 1029 3 of of IN cord-010092-uftc8inx 1029 4 CD4 CD4 NNP cord-010092-uftc8inx 1029 5 + + CC cord-010092-uftc8inx 1029 6 T t NN cord-010092-uftc8inx 1029 7 lymphocytes lymphocyte NNS cord-010092-uftc8inx 1029 8 was be VBD cord-010092-uftc8inx 1029 9 mainly mainly RB cord-010092-uftc8inx 1029 10 stimulated stimulate VBN cord-010092-uftc8inx 1029 11 by by IN cord-010092-uftc8inx 1029 12 specific specific JJ cord-010092-uftc8inx 1029 13 HBV HBV NNP cord-010092-uftc8inx 1029 14 polypeptide polypeptide NN cord-010092-uftc8inx 1029 15 pool pool NN cord-010092-uftc8inx 1029 16 , , , cord-010092-uftc8inx 1029 17 and and CC cord-010092-uftc8inx 1029 18 the the DT cord-010092-uftc8inx 1029 19 proliferation proliferation NN cord-010092-uftc8inx 1029 20 rates rate NNS cord-010092-uftc8inx 1029 21 of of IN cord-010092-uftc8inx 1029 22 OBI OBI NNP cord-010092-uftc8inx 1029 23 group group NN cord-010092-uftc8inx 1029 24 and and CC cord-010092-uftc8inx 1029 25 CHB CHB NNP cord-010092-uftc8inx 1029 26 group group NN cord-010092-uftc8inx 1029 27 were be VBD cord-010092-uftc8inx 1029 28 significantly significantly RB cord-010092-uftc8inx 1029 29 higher high JJR cord-010092-uftc8inx 1029 30 than than IN cord-010092-uftc8inx 1029 31 those those DT cord-010092-uftc8inx 1029 32 of of IN cord-010092-uftc8inx 1029 33 HC HC NNP cord-010092-uftc8inx 1029 34 group group NN cord-010092-uftc8inx 1029 35 ( ( -LRB- cord-010092-uftc8inx 1029 36 3.0 3.0 CD cord-010092-uftc8inx 1029 37 % % NN cord-010092-uftc8inx 1029 38 , , , cord-010092-uftc8inx 1029 39 3.3 3.3 CD cord-010092-uftc8inx 1029 40 % % NN cord-010092-uftc8inx 1029 41 vs. vs. IN cord-010092-uftc8inx 1029 42 1.7 1.7 CD cord-010092-uftc8inx 1029 43 % % NN cord-010092-uftc8inx 1029 44 ) ) -RRB- cord-010092-uftc8inx 1029 45 , , , cord-010092-uftc8inx 1029 46 with with IN cord-010092-uftc8inx 1029 47 significant significant JJ cord-010092-uftc8inx 1029 48 difference difference NN cord-010092-uftc8inx 1029 49 ( ( -LRB- cord-010092-uftc8inx 1029 50 3.0 3.0 CD cord-010092-uftc8inx 1029 51 % % NN cord-010092-uftc8inx 1029 52 vs. vs. CC cord-010092-uftc8inx 1029 53 1.7 1.7 CD cord-010092-uftc8inx 1029 54 % % NN cord-010092-uftc8inx 1029 55 , , , cord-010092-uftc8inx 1029 56 P p NN cord-010092-uftc8inx 1029 57 = = SYM cord-010092-uftc8inx 1029 58 0.016 0.016 CD cord-010092-uftc8inx 1029 59 , , , cord-010092-uftc8inx 1029 60 3.3 3.3 CD cord-010092-uftc8inx 1029 61 % % NN cord-010092-uftc8inx 1029 62 vs vs IN cord-010092-uftc8inx 1029 63 1.7 1.7 CD cord-010092-uftc8inx 1029 64 % % NN cord-010092-uftc8inx 1029 65 , , , cord-010092-uftc8inx 1029 66 P p NN cord-010092-uftc8inx 1029 67 < < XX cord-010092-uftc8inx 1029 68 0.001 0.001 CD cord-010092-uftc8inx 1029 69 ) ) -RRB- cord-010092-uftc8inx 1029 70 . . . cord-010092-uftc8inx 1030 1 2 2 LS cord-010092-uftc8inx 1030 2 . . . cord-010092-uftc8inx 1031 1 The the DT cord-010092-uftc8inx 1031 2 frequency frequency NN cord-010092-uftc8inx 1031 3 of of IN cord-010092-uftc8inx 1031 4 specific specific JJ cord-010092-uftc8inx 1031 5 IFN IFN NNP cord-010092-uftc8inx 1031 6 - - HYPH cord-010092-uftc8inx 1031 7 c c NNP cord-010092-uftc8inx 1031 8 secreted secrete VBD cord-010092-uftc8inx 1031 9 T T NNP cord-010092-uftc8inx 1031 10 cells cell NNS cord-010092-uftc8inx 1031 11 . . . cord-010092-uftc8inx 1032 1 The the DT cord-010092-uftc8inx 1032 2 response response NN cord-010092-uftc8inx 1032 3 intensity intensity NN cord-010092-uftc8inx 1032 4 of of IN cord-010092-uftc8inx 1032 5 the the DT cord-010092-uftc8inx 1032 6 OBI OBI NNP cord-010092-uftc8inx 1032 7 group group NN cord-010092-uftc8inx 1032 8 ( ( -LRB- cord-010092-uftc8inx 1032 9 25 25 CD cord-010092-uftc8inx 1032 10 SFC/10 sfc/10 JJ cord-010092-uftc8inx 1032 11 6 6 CD cord-010092-uftc8inx 1032 12 PBMCs pbmc NNS cord-010092-uftc8inx 1032 13 ) ) -RRB- cord-010092-uftc8inx 1032 14 and and CC cord-010092-uftc8inx 1032 15 CHB CHB NNP cord-010092-uftc8inx 1032 16 group group NN cord-010092-uftc8inx 1032 17 ( ( -LRB- cord-010092-uftc8inx 1032 18 25 25 CD cord-010092-uftc8inx 1032 19 SFC/10 sfc/10 JJ cord-010092-uftc8inx 1032 20 6 6 CD cord-010092-uftc8inx 1032 21 PBMCs pbmc NNS cord-010092-uftc8inx 1032 22 ) ) -RRB- cord-010092-uftc8inx 1032 23 was be VBD cord-010092-uftc8inx 1032 24 higher high JJR cord-010092-uftc8inx 1032 25 than than IN cord-010092-uftc8inx 1032 26 that that DT cord-010092-uftc8inx 1032 27 of of IN cord-010092-uftc8inx 1032 28 the the DT cord-010092-uftc8inx 1032 29 HC HC NNP cord-010092-uftc8inx 1032 30 group group NN cord-010092-uftc8inx 1032 31 ( ( -LRB- cord-010092-uftc8inx 1032 32 5 5 CD cord-010092-uftc8inx 1032 33 SFC/10 sfc/10 JJ cord-010092-uftc8inx 1032 34 6 6 CD cord-010092-uftc8inx 1032 35 PBMCs pbmc NNS cord-010092-uftc8inx 1032 36 ) ) -RRB- cord-010092-uftc8inx 1032 37 under under IN cord-010092-uftc8inx 1032 38 the the DT cord-010092-uftc8inx 1032 39 stimulation stimulation NN cord-010092-uftc8inx 1032 40 of of IN cord-010092-uftc8inx 1032 41 HBV HBV NNP cord-010092-uftc8inx 1032 42 polypeptide polypeptide NN cord-010092-uftc8inx 1032 43 pool pool NN cord-010092-uftc8inx 1032 44 , , , cord-010092-uftc8inx 1032 45 and and CC cord-010092-uftc8inx 1032 46 the the DT cord-010092-uftc8inx 1032 47 positive positive JJ cord-010092-uftc8inx 1032 48 rate rate NN cord-010092-uftc8inx 1032 49 of of IN cord-010092-uftc8inx 1032 50 T T NNP cord-010092-uftc8inx 1032 51 cell cell NN cord-010092-uftc8inx 1032 52 response response NN cord-010092-uftc8inx 1032 53 to to IN cord-010092-uftc8inx 1032 54 the the DT cord-010092-uftc8inx 1032 55 stimulation stimulation NN cord-010092-uftc8inx 1032 56 of of IN cord-010092-uftc8inx 1032 57 HBV HBV NNP cord-010092-uftc8inx 1032 58 polypeptide polypeptide NN cord-010092-uftc8inx 1032 59 pool pool NN cord-010092-uftc8inx 1032 60 was be VBD cord-010092-uftc8inx 1032 61 the the DT cord-010092-uftc8inx 1032 62 highest high JJS cord-010092-uftc8inx 1032 63 in in IN cord-010092-uftc8inx 1032 64 the the DT cord-010092-uftc8inx 1032 65 OBI OBI NNP cord-010092-uftc8inx 1032 66 group group NN cord-010092-uftc8inx 1032 67 ( ( -LRB- cord-010092-uftc8inx 1032 68 64.0 64.0 CD cord-010092-uftc8inx 1032 69 % % NN cord-010092-uftc8inx 1032 70 ) ) -RRB- cord-010092-uftc8inx 1032 71 . . . cord-010092-uftc8inx 1033 1 Summary Summary NNP cord-010092-uftc8inx 1033 2 / / SYM cord-010092-uftc8inx 1033 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 1033 4 : : : cord-010092-uftc8inx 1034 1 Both both DT cord-010092-uftc8inx 1034 2 OBI OBI NNP cord-010092-uftc8inx 1034 3 and and CC cord-010092-uftc8inx 1034 4 CHB CHB NNP cord-010092-uftc8inx 1034 5 had have VBD cord-010092-uftc8inx 1034 6 higher high JJR cord-010092-uftc8inx 1034 7 rates rate NNS cord-010092-uftc8inx 1034 8 of of IN cord-010092-uftc8inx 1034 9 HBV HBV NNP cord-010092-uftc8inx 1034 10 - - HYPH cord-010092-uftc8inx 1034 11 specific specific JJ cord-010092-uftc8inx 1034 12 T T NNP cord-010092-uftc8inx 1034 13 effector effector NN cord-010092-uftc8inx 1034 14 cell cell NN cord-010092-uftc8inx 1034 15 proliferation proliferation NN cord-010092-uftc8inx 1034 16 and and CC cord-010092-uftc8inx 1034 17 IFN IFN NNP cord-010092-uftc8inx 1034 18 - - HYPH cord-010092-uftc8inx 1034 19 c c JJ cord-010092-uftc8inx 1034 20 secretion secretion NN cord-010092-uftc8inx 1034 21 than than IN cord-010092-uftc8inx 1034 22 the the DT cord-010092-uftc8inx 1034 23 healthy healthy JJ cord-010092-uftc8inx 1034 24 control control NN cord-010092-uftc8inx 1034 25 group group NN cord-010092-uftc8inx 1034 26 . . . cord-010092-uftc8inx 1035 1 Compared compare VBN cord-010092-uftc8inx 1035 2 with with IN cord-010092-uftc8inx 1035 3 the the DT cord-010092-uftc8inx 1035 4 CHB CHB NNP cord-010092-uftc8inx 1035 5 group group NN cord-010092-uftc8inx 1035 6 , , , cord-010092-uftc8inx 1035 7 OBI OBI NNP cord-010092-uftc8inx 1035 8 group group NN cord-010092-uftc8inx 1035 9 had have VBD cord-010092-uftc8inx 1035 10 a a DT cord-010092-uftc8inx 1035 11 higher high JJR cord-010092-uftc8inx 1035 12 positive positive JJ cord-010092-uftc8inx 1035 13 rate rate NN cord-010092-uftc8inx 1035 14 of of IN cord-010092-uftc8inx 1035 15 T T NNP cord-010092-uftc8inx 1035 16 cell cell NN cord-010092-uftc8inx 1035 17 response response NN cord-010092-uftc8inx 1035 18 , , , cord-010092-uftc8inx 1035 19 which which WDT cord-010092-uftc8inx 1035 20 may may MD cord-010092-uftc8inx 1035 21 be be VB cord-010092-uftc8inx 1035 22 one one CD cord-010092-uftc8inx 1035 23 of of IN cord-010092-uftc8inx 1035 24 the the DT cord-010092-uftc8inx 1035 25 causes cause NNS cord-010092-uftc8inx 1035 26 of of IN cord-010092-uftc8inx 1035 27 host host NN cord-010092-uftc8inx 1035 28 immunity immunity NN cord-010092-uftc8inx 1035 29 resulting result VBG cord-010092-uftc8inx 1035 30 in in IN cord-010092-uftc8inx 1035 31 OBI OBI NNP cord-010092-uftc8inx 1035 32 . . . cord-010092-uftc8inx 1036 1 Further further JJ cord-010092-uftc8inx 1036 2 studies study NNS cord-010092-uftc8inx 1036 3 on on IN cord-010092-uftc8inx 1036 4 other other JJ cord-010092-uftc8inx 1036 5 immune immune JJ cord-010092-uftc8inx 1036 6 factors factor NNS cord-010092-uftc8inx 1036 7 are be VBP cord-010092-uftc8inx 1036 8 required require VBN cord-010092-uftc8inx 1036 9 . . . cord-010092-uftc8inx 1037 1 Background background NN cord-010092-uftc8inx 1037 2 : : : cord-010092-uftc8inx 1038 1 Western western JJ cord-010092-uftc8inx 1038 2 blood blood NN cord-010092-uftc8inx 1038 3 transfusion transfusion NN cord-010092-uftc8inx 1038 4 practices practice NNS cord-010092-uftc8inx 1038 5 are be VBP cord-010092-uftc8inx 1038 6 currently currently RB cord-010092-uftc8inx 1038 7 changing change VBG cord-010092-uftc8inx 1038 8 due due IN cord-010092-uftc8inx 1038 9 to to IN cord-010092-uftc8inx 1038 10 various various JJ cord-010092-uftc8inx 1038 11 drivers driver NNS cord-010092-uftc8inx 1038 12 such such JJ cord-010092-uftc8inx 1038 13 as as IN cord-010092-uftc8inx 1038 14 blood blood NN cord-010092-uftc8inx 1038 15 management management NN cord-010092-uftc8inx 1038 16 policies policy NNS cord-010092-uftc8inx 1038 17 , , , cord-010092-uftc8inx 1038 18 ongoing ongoing JJ cord-010092-uftc8inx 1038 19 technological technological JJ cord-010092-uftc8inx 1038 20 developments development NNS cord-010092-uftc8inx 1038 21 , , , cord-010092-uftc8inx 1038 22 and and CC cord-010092-uftc8inx 1038 23 new new JJ cord-010092-uftc8inx 1038 24 therapeutic therapeutic JJ cord-010092-uftc8inx 1038 25 options option NNS cord-010092-uftc8inx 1038 26 . . . cord-010092-uftc8inx 1039 1 In in IN cord-010092-uftc8inx 1039 2 the the DT cord-010092-uftc8inx 1039 3 Netherlands Netherlands NNP cord-010092-uftc8inx 1039 4 , , , cord-010092-uftc8inx 1039 5 as as IN cord-010092-uftc8inx 1039 6 in in IN cord-010092-uftc8inx 1039 7 many many JJ cord-010092-uftc8inx 1039 8 high high JJ cord-010092-uftc8inx 1039 9 - - HYPH cord-010092-uftc8inx 1039 10 income income NN cord-010092-uftc8inx 1039 11 countries country NNS cord-010092-uftc8inx 1039 12 , , , cord-010092-uftc8inx 1039 13 these these DT cord-010092-uftc8inx 1039 14 have have VBP cord-010092-uftc8inx 1039 15 resulted result VBN cord-010092-uftc8inx 1039 16 in in IN cord-010092-uftc8inx 1039 17 a a DT cord-010092-uftc8inx 1039 18 diminishing diminish VBG cord-010092-uftc8inx 1039 19 trend trend NN cord-010092-uftc8inx 1039 20 of of IN cord-010092-uftc8inx 1039 21 red red JJ cord-010092-uftc8inx 1039 22 blood blood NN cord-010092-uftc8inx 1039 23 cells cell NNS cord-010092-uftc8inx 1039 24 . . . cord-010092-uftc8inx 1040 1 Therefore therefore RB cord-010092-uftc8inx 1040 2 , , , cord-010092-uftc8inx 1040 3 it -PRON- PRP cord-010092-uftc8inx 1040 4 is be VBZ cord-010092-uftc8inx 1040 5 important important JJ cord-010092-uftc8inx 1040 6 for for IN cord-010092-uftc8inx 1040 7 blood blood NN cord-010092-uftc8inx 1040 8 bank bank NN cord-010092-uftc8inx 1040 9 management management NN cord-010092-uftc8inx 1040 10 to to TO cord-010092-uftc8inx 1040 11 anticipate anticipate VB cord-010092-uftc8inx 1040 12 the the DT cord-010092-uftc8inx 1040 13 future future JJ cord-010092-uftc8inx 1040 14 demand demand NN cord-010092-uftc8inx 1040 15 of of IN cord-010092-uftc8inx 1040 16 blood blood NN cord-010092-uftc8inx 1040 17 products product NNS cord-010092-uftc8inx 1040 18 for for IN cord-010092-uftc8inx 1040 19 the the DT cord-010092-uftc8inx 1040 20 sake sake NN cord-010092-uftc8inx 1040 21 of of IN cord-010092-uftc8inx 1040 22 medium medium JJ cord-010092-uftc8inx 1040 23 and and CC cord-010092-uftc8inx 1040 24 long long JJ cord-010092-uftc8inx 1040 25 term term NN cord-010092-uftc8inx 1040 26 decision decision NN cord-010092-uftc8inx 1040 27 making making NN cord-010092-uftc8inx 1040 28 . . . cord-010092-uftc8inx 1041 1 To to TO cord-010092-uftc8inx 1041 2 support support VB cord-010092-uftc8inx 1041 3 this this DT cord-010092-uftc8inx 1041 4 decision decision NN cord-010092-uftc8inx 1041 5 making making NN cord-010092-uftc8inx 1041 6 , , , cord-010092-uftc8inx 1041 7 we -PRON- PRP cord-010092-uftc8inx 1041 8 have have VBP cord-010092-uftc8inx 1041 9 employed employ VBN cord-010092-uftc8inx 1041 10 scenario scenario NN cord-010092-uftc8inx 1041 11 development development NN cord-010092-uftc8inx 1041 12 , , , cord-010092-uftc8inx 1041 13 which which WDT cord-010092-uftc8inx 1041 14 is be VBZ cord-010092-uftc8inx 1041 15 used use VBN cord-010092-uftc8inx 1041 16 in in IN cord-010092-uftc8inx 1041 17 many many JJ cord-010092-uftc8inx 1041 18 other other JJ cord-010092-uftc8inx 1041 19 sectors sector NNS cord-010092-uftc8inx 1041 20 ( ( -LRB- cord-010092-uftc8inx 1041 21 such such JJ cord-010092-uftc8inx 1041 22 as as IN cord-010092-uftc8inx 1041 23 finance finance NN cord-010092-uftc8inx 1041 24 and and CC cord-010092-uftc8inx 1041 25 transportation transportation NN cord-010092-uftc8inx 1041 26 ) ) -RRB- cord-010092-uftc8inx 1041 27 and and CC cord-010092-uftc8inx 1041 28 can can MD cord-010092-uftc8inx 1041 29 also also RB cord-010092-uftc8inx 1041 30 be be VB cord-010092-uftc8inx 1041 31 applied apply VBN cord-010092-uftc8inx 1041 32 to to IN cord-010092-uftc8inx 1041 33 blood blood NN cord-010092-uftc8inx 1041 34 transfusion transfusion NN cord-010092-uftc8inx 1041 35 . . . cord-010092-uftc8inx 1042 1 Building build VBG cord-010092-uftc8inx 1042 2 upon upon IN cord-010092-uftc8inx 1042 3 a a DT cord-010092-uftc8inx 1042 4 prior prior JJ cord-010092-uftc8inx 1042 5 literature literature NN cord-010092-uftc8inx 1042 6 review review NN cord-010092-uftc8inx 1042 7 and and CC cord-010092-uftc8inx 1042 8 semi semi JJ cord-010092-uftc8inx 1042 9 - - JJ cord-010092-uftc8inx 1042 10 structured structured JJ cord-010092-uftc8inx 1042 11 interviews interview NNS cord-010092-uftc8inx 1042 12 of of IN cord-010092-uftc8inx 1042 13 international international JJ cord-010092-uftc8inx 1042 14 experts expert NNS cord-010092-uftc8inx 1042 15 , , , cord-010092-uftc8inx 1042 16 we -PRON- PRP cord-010092-uftc8inx 1042 17 gathered gather VBD cord-010092-uftc8inx 1042 18 experts expert NNS cord-010092-uftc8inx 1042 19 together together RB cord-010092-uftc8inx 1042 20 for for IN cord-010092-uftc8inx 1042 21 scenario scenario NN cord-010092-uftc8inx 1042 22 sessions session NNS cord-010092-uftc8inx 1042 23 to to TO cord-010092-uftc8inx 1042 24 assess assess VB cord-010092-uftc8inx 1042 25 the the DT cord-010092-uftc8inx 1042 26 opportunities opportunity NNS cord-010092-uftc8inx 1042 27 and and CC cord-010092-uftc8inx 1042 28 threats threat NNS cord-010092-uftc8inx 1042 29 for for IN cord-010092-uftc8inx 1042 30 Sanquin Sanquin NNP cord-010092-uftc8inx 1042 31 's 's POS cord-010092-uftc8inx 1042 32 medium medium JJ cord-010092-uftc8inx 1042 33 - - HYPH cord-010092-uftc8inx 1042 34 term term NN cord-010092-uftc8inx 1042 35 ( ( -LRB- cord-010092-uftc8inx 1042 36 15 15 CD cord-010092-uftc8inx 1042 37 - - SYM cord-010092-uftc8inx 1042 38 20 20 CD cord-010092-uftc8inx 1042 39 years year NNS cord-010092-uftc8inx 1042 40 ) ) -RRB- cord-010092-uftc8inx 1043 1 strategy strategy NN cord-010092-uftc8inx 1043 2 using use VBG cord-010092-uftc8inx 1043 3 an an DT cord-010092-uftc8inx 1043 4 online online JJ cord-010092-uftc8inx 1043 5 platform platform NN cord-010092-uftc8inx 1043 6 and and CC cord-010092-uftc8inx 1043 7 face face NN cord-010092-uftc8inx 1043 8 - - HYPH cord-010092-uftc8inx 1043 9 to to IN cord-010092-uftc8inx 1043 10 - - HYPH cord-010092-uftc8inx 1043 11 face face NN cord-010092-uftc8inx 1043 12 discussions discussion NNS cord-010092-uftc8inx 1043 13 . . . cord-010092-uftc8inx 1044 1 Aims aim VBZ cord-010092-uftc8inx 1044 2 : : : cord-010092-uftc8inx 1044 3 To to TO cord-010092-uftc8inx 1044 4 assess assess VB cord-010092-uftc8inx 1044 5 for for IN cord-010092-uftc8inx 1044 6 opportunities opportunity NNS cord-010092-uftc8inx 1044 7 , , , cord-010092-uftc8inx 1044 8 threats threat NNS cord-010092-uftc8inx 1044 9 , , , cord-010092-uftc8inx 1044 10 and and CC cord-010092-uftc8inx 1044 11 the the DT cord-010092-uftc8inx 1044 12 organizational organizational JJ cord-010092-uftc8inx 1044 13 implications implication NNS cord-010092-uftc8inx 1044 14 thereof thereof RB cord-010092-uftc8inx 1044 15 for for IN cord-010092-uftc8inx 1044 16 the the DT cord-010092-uftc8inx 1044 17 medium medium JJ cord-010092-uftc8inx 1044 18 - - HYPH cord-010092-uftc8inx 1044 19 term term NN cord-010092-uftc8inx 1044 20 future future NN cord-010092-uftc8inx 1044 21 of of IN cord-010092-uftc8inx 1044 22 Sanquin Sanquin NNP cord-010092-uftc8inx 1044 23 , , , cord-010092-uftc8inx 1044 24 the the DT cord-010092-uftc8inx 1044 25 Dutch dutch JJ cord-010092-uftc8inx 1044 26 national national JJ cord-010092-uftc8inx 1044 27 blood blood NN cord-010092-uftc8inx 1044 28 bank bank NN cord-010092-uftc8inx 1044 29 . . . cord-010092-uftc8inx 1045 1 Methods method NNS cord-010092-uftc8inx 1045 2 : : : cord-010092-uftc8inx 1046 1 Twenty twenty CD cord-010092-uftc8inx 1046 2 - - HYPH cord-010092-uftc8inx 1046 3 one one CD cord-010092-uftc8inx 1046 4 multidisciplinary multidisciplinary JJ cord-010092-uftc8inx 1046 5 experts expert NNS cord-010092-uftc8inx 1046 6 in in IN cord-010092-uftc8inx 1046 7 blood blood NN cord-010092-uftc8inx 1046 8 transfusion transfusion NN cord-010092-uftc8inx 1046 9 agreed agree VBD cord-010092-uftc8inx 1046 10 to to TO cord-010092-uftc8inx 1046 11 participate participate VB cord-010092-uftc8inx 1046 12 and and CC cord-010092-uftc8inx 1046 13 were be VBD cord-010092-uftc8inx 1046 14 separated separate VBN cord-010092-uftc8inx 1046 15 into into IN cord-010092-uftc8inx 1046 16 two two CD cord-010092-uftc8inx 1046 17 groups group NNS cord-010092-uftc8inx 1046 18 for for IN cord-010092-uftc8inx 1046 19 half half JJ cord-010092-uftc8inx 1046 20 - - HYPH cord-010092-uftc8inx 1046 21 day day NN cord-010092-uftc8inx 1046 22 interactive interactive JJ cord-010092-uftc8inx 1046 23 sessions session NNS cord-010092-uftc8inx 1046 24 . . . cord-010092-uftc8inx 1047 1 Using use VBG cord-010092-uftc8inx 1047 2 an an DT cord-010092-uftc8inx 1047 3 iterative iterative JJ cord-010092-uftc8inx 1047 4 process process NN cord-010092-uftc8inx 1047 5 through through IN cord-010092-uftc8inx 1047 6 an an DT cord-010092-uftc8inx 1047 7 online online JJ cord-010092-uftc8inx 1047 8 platform platform NN cord-010092-uftc8inx 1047 9 , , , cord-010092-uftc8inx 1047 10 experts expert NNS cord-010092-uftc8inx 1047 11 brainstormed brainstorm VBD cord-010092-uftc8inx 1047 12 opportunities opportunity NNS cord-010092-uftc8inx 1047 13 and and CC cord-010092-uftc8inx 1047 14 threats threat NNS cord-010092-uftc8inx 1047 15 for for IN cord-010092-uftc8inx 1047 16 Sanquin Sanquin NNP cord-010092-uftc8inx 1047 17 , , , cord-010092-uftc8inx 1047 18 which which WDT cord-010092-uftc8inx 1047 19 were be VBD cord-010092-uftc8inx 1047 20 categorized categorize VBN cord-010092-uftc8inx 1047 21 into into IN cord-010092-uftc8inx 1047 22 themes theme NNS cord-010092-uftc8inx 1047 23 . . . cord-010092-uftc8inx 1048 1 These these DT cord-010092-uftc8inx 1048 2 themes theme NNS cord-010092-uftc8inx 1048 3 were be VBD cord-010092-uftc8inx 1048 4 ranked rank VBN cord-010092-uftc8inx 1048 5 according accord VBG cord-010092-uftc8inx 1048 6 to to IN cord-010092-uftc8inx 1048 7 importance importance NN cord-010092-uftc8inx 1048 8 and and CC cord-010092-uftc8inx 1048 9 certainty certainty NN cord-010092-uftc8inx 1048 10 , , , cord-010092-uftc8inx 1048 11 and and CC cord-010092-uftc8inx 1048 12 through through IN cord-010092-uftc8inx 1048 13 consensus consensus NN cord-010092-uftc8inx 1048 14 , , , cord-010092-uftc8inx 1048 15 experts expert NNS cord-010092-uftc8inx 1048 16 chose choose VBD cord-010092-uftc8inx 1048 17 two two CD cord-010092-uftc8inx 1048 18 themes theme NNS cord-010092-uftc8inx 1048 19 with with IN cord-010092-uftc8inx 1048 20 high high JJ cord-010092-uftc8inx 1048 21 impact impact NN cord-010092-uftc8inx 1048 22 and and CC cord-010092-uftc8inx 1048 23 high high JJ cord-010092-uftc8inx 1048 24 uncertainty uncertainty NN cord-010092-uftc8inx 1048 25 . . . cord-010092-uftc8inx 1049 1 For for IN cord-010092-uftc8inx 1049 2 these these DT cord-010092-uftc8inx 1049 3 chosen choose VBN cord-010092-uftc8inx 1049 4 themes theme NNS cord-010092-uftc8inx 1049 5 , , , cord-010092-uftc8inx 1049 6 specific specific JJ cord-010092-uftc8inx 1049 7 actions action NNS cord-010092-uftc8inx 1049 8 for for IN cord-010092-uftc8inx 1049 9 the the DT cord-010092-uftc8inx 1049 10 blood blood NN cord-010092-uftc8inx 1049 11 bank bank NN cord-010092-uftc8inx 1049 12 were be VBD cord-010092-uftc8inx 1049 13 listed list VBN cord-010092-uftc8inx 1049 14 to to TO cord-010092-uftc8inx 1049 15 mitigate mitigate VB cord-010092-uftc8inx 1049 16 and/or and/or CC cord-010092-uftc8inx 1049 17 enhance enhance VB cord-010092-uftc8inx 1049 18 the the DT cord-010092-uftc8inx 1049 19 threat threat NN cord-010092-uftc8inx 1049 20 or or CC cord-010092-uftc8inx 1049 21 opportunity opportunity NN cord-010092-uftc8inx 1049 22 . . . cord-010092-uftc8inx 1050 1 Discussions discussion NNS cord-010092-uftc8inx 1050 2 were be VBD cord-010092-uftc8inx 1050 3 ample ample JJ cord-010092-uftc8inx 1050 4 throughout throughout IN cord-010092-uftc8inx 1050 5 . . . cord-010092-uftc8inx 1051 1 Results result NNS cord-010092-uftc8inx 1051 2 : : : cord-010092-uftc8inx 1051 3 With with IN cord-010092-uftc8inx 1051 4 regards regard NNS cord-010092-uftc8inx 1051 5 to to IN cord-010092-uftc8inx 1051 6 opportunities opportunity NNS cord-010092-uftc8inx 1051 7 and and CC cord-010092-uftc8inx 1051 8 threats threat NNS cord-010092-uftc8inx 1051 9 for for IN cord-010092-uftc8inx 1051 10 Sanquin Sanquin NNP cord-010092-uftc8inx 1051 11 's 's POS cord-010092-uftc8inx 1051 12 medium medium JJ cord-010092-uftc8inx 1051 13 term term NN cord-010092-uftc8inx 1051 14 strategy strategy NN cord-010092-uftc8inx 1051 15 , , , cord-010092-uftc8inx 1051 16 experts expert NNS cord-010092-uftc8inx 1051 17 brainstormed brainstorm VBD cord-010092-uftc8inx 1051 18 many many JJ cord-010092-uftc8inx 1051 19 ideas idea NNS cord-010092-uftc8inx 1051 20 and and CC cord-010092-uftc8inx 1051 21 categorized categorize VBD cord-010092-uftc8inx 1051 22 them -PRON- PRP cord-010092-uftc8inx 1051 23 under under IN cord-010092-uftc8inx 1051 24 10 10 CD cord-010092-uftc8inx 1051 25 themes theme NNS cord-010092-uftc8inx 1051 26 : : : cord-010092-uftc8inx 1051 27 political political JJ cord-010092-uftc8inx 1051 28 context/ context/ NNS cord-010092-uftc8inx 1051 29 changing change VBG cord-010092-uftc8inx 1051 30 legislation legislation NN cord-010092-uftc8inx 1051 31 , , , cord-010092-uftc8inx 1051 32 novel novel JJ cord-010092-uftc8inx 1051 33 products product NNS cord-010092-uftc8inx 1051 34 and and CC cord-010092-uftc8inx 1051 35 alternative alternative JJ cord-010092-uftc8inx 1051 36 applications application NNS cord-010092-uftc8inx 1051 37 , , , cord-010092-uftc8inx 1051 38 donors donor NNS cord-010092-uftc8inx 1051 39 , , , cord-010092-uftc8inx 1051 40 international international JJ cord-010092-uftc8inx 1051 41 markets market NNS cord-010092-uftc8inx 1051 42 , , , cord-010092-uftc8inx 1051 43 commercialization commercialization NN cord-010092-uftc8inx 1051 44 , , , cord-010092-uftc8inx 1051 45 digitalization digitalization NN cord-010092-uftc8inx 1051 46 , , , cord-010092-uftc8inx 1051 47 change change NN cord-010092-uftc8inx 1051 48 in in IN cord-010092-uftc8inx 1051 49 perceptions perception NNS cord-010092-uftc8inx 1051 50 , , , cord-010092-uftc8inx 1051 51 research research NN cord-010092-uftc8inx 1051 52 , , , cord-010092-uftc8inx 1051 53 demand demand NN cord-010092-uftc8inx 1051 54 , , , cord-010092-uftc8inx 1051 55 and and CC cord-010092-uftc8inx 1051 56 organizational organizational JJ cord-010092-uftc8inx 1051 57 structure structure NN cord-010092-uftc8inx 1051 58 . . . cord-010092-uftc8inx 1052 1 After after IN cord-010092-uftc8inx 1052 2 ranking rank VBG cord-010092-uftc8inx 1052 3 for for IN cord-010092-uftc8inx 1052 4 importance importance NN cord-010092-uftc8inx 1052 5 and and CC cord-010092-uftc8inx 1052 6 certainty certainty NN cord-010092-uftc8inx 1052 7 , , , cord-010092-uftc8inx 1052 8 six six CD cord-010092-uftc8inx 1052 9 themes theme NNS cord-010092-uftc8inx 1052 10 were be VBD cord-010092-uftc8inx 1052 11 chosen choose VBN cord-010092-uftc8inx 1052 12 : : : cord-010092-uftc8inx 1052 13 change change VB cord-010092-uftc8inx 1052 14 in in IN cord-010092-uftc8inx 1052 15 perceptions perception NNS cord-010092-uftc8inx 1052 16 , , , cord-010092-uftc8inx 1052 17 international international JJ cord-010092-uftc8inx 1052 18 markets market NNS cord-010092-uftc8inx 1052 19 , , , cord-010092-uftc8inx 1052 20 political political JJ cord-010092-uftc8inx 1052 21 context context NN cord-010092-uftc8inx 1052 22 ( ( -LRB- cord-010092-uftc8inx 1052 23 opportunities opportunity NNS cord-010092-uftc8inx 1052 24 ) ) -RRB- cord-010092-uftc8inx 1052 25 , , , cord-010092-uftc8inx 1052 26 demand demand NN cord-010092-uftc8inx 1052 27 ( ( -LRB- cord-010092-uftc8inx 1052 28 opportunities opportunity NNS cord-010092-uftc8inx 1052 29 ) ) -RRB- cord-010092-uftc8inx 1052 30 , , , cord-010092-uftc8inx 1052 31 research research NN cord-010092-uftc8inx 1052 32 ( ( -LRB- cord-010092-uftc8inx 1052 33 vulnerabilities vulnerability NNS cord-010092-uftc8inx 1052 34 ) ) -RRB- cord-010092-uftc8inx 1052 35 , , , cord-010092-uftc8inx 1052 36 and and CC cord-010092-uftc8inx 1052 37 donor donor NN cord-010092-uftc8inx 1052 38 ( ( -LRB- cord-010092-uftc8inx 1052 39 vulnerabilities vulnerability NNS cord-010092-uftc8inx 1052 40 ) ) -RRB- cord-010092-uftc8inx 1052 41 . . . cord-010092-uftc8inx 1053 1 For for IN cord-010092-uftc8inx 1053 2 each each DT cord-010092-uftc8inx 1053 3 of of IN cord-010092-uftc8inx 1053 4 these these DT cord-010092-uftc8inx 1053 5 themes theme NNS cord-010092-uftc8inx 1053 6 experts expert NNS cord-010092-uftc8inx 1053 7 provided provide VBD cord-010092-uftc8inx 1053 8 specific specific JJ cord-010092-uftc8inx 1053 9 actions action NNS cord-010092-uftc8inx 1053 10 for for IN cord-010092-uftc8inx 1053 11 the the DT cord-010092-uftc8inx 1053 12 organizations organization NNS cord-010092-uftc8inx 1053 13 to to TO cord-010092-uftc8inx 1053 14 mitigate mitigate VB cord-010092-uftc8inx 1053 15 threats threat NNS cord-010092-uftc8inx 1053 16 or or CC cord-010092-uftc8inx 1053 17 stimulate stimulate VB cord-010092-uftc8inx 1053 18 opportunities opportunity NNS cord-010092-uftc8inx 1053 19 accordingly accordingly RB cord-010092-uftc8inx 1053 20 . . . cord-010092-uftc8inx 1054 1 These these DT cord-010092-uftc8inx 1054 2 actions action NNS cord-010092-uftc8inx 1054 3 included include VBD cord-010092-uftc8inx 1054 4 increased increase VBD cord-010092-uftc8inx 1054 5 transparency transparency NN cord-010092-uftc8inx 1054 6 and and CC cord-010092-uftc8inx 1054 7 improved improved JJ cord-010092-uftc8inx 1054 8 communication communication NN cord-010092-uftc8inx 1054 9 with with IN cord-010092-uftc8inx 1054 10 the the DT cord-010092-uftc8inx 1054 11 ( ( -LRB- cord-010092-uftc8inx 1054 12 donor donor NN cord-010092-uftc8inx 1054 13 ) ) -RRB- cord-010092-uftc8inx 1054 14 public public NN cord-010092-uftc8inx 1054 15 , , , cord-010092-uftc8inx 1054 16 lobbying lobby VBG cord-010092-uftc8inx 1054 17 in in IN cord-010092-uftc8inx 1054 18 political political JJ cord-010092-uftc8inx 1054 19 spheres sphere NNS cord-010092-uftc8inx 1054 20 , , , cord-010092-uftc8inx 1054 21 increased increase VBN cord-010092-uftc8inx 1054 22 activities activity NNS cord-010092-uftc8inx 1054 23 in in IN cord-010092-uftc8inx 1054 24 educational educational JJ cord-010092-uftc8inx 1054 25 institutes institute NNS cord-010092-uftc8inx 1054 26 and and CC cord-010092-uftc8inx 1054 27 large large JJ cord-010092-uftc8inx 1054 28 funding funding NN cord-010092-uftc8inx 1054 29 organizations organization NNS cord-010092-uftc8inx 1054 30 , , , cord-010092-uftc8inx 1054 31 and and CC cord-010092-uftc8inx 1054 32 creating create VBG cord-010092-uftc8inx 1054 33 and and CC cord-010092-uftc8inx 1054 34 collaborating collaborate VBG cord-010092-uftc8inx 1054 35 on on IN cord-010092-uftc8inx 1054 36 novel novel JJ cord-010092-uftc8inx 1054 37 blood blood NN cord-010092-uftc8inx 1054 38 products product NNS cord-010092-uftc8inx 1054 39 on on IN cord-010092-uftc8inx 1054 40 an an DT cord-010092-uftc8inx 1054 41 international international JJ cord-010092-uftc8inx 1054 42 level level NN cord-010092-uftc8inx 1054 43 , , , cord-010092-uftc8inx 1054 44 to to TO cord-010092-uftc8inx 1054 45 name name VB cord-010092-uftc8inx 1054 46 a a DT cord-010092-uftc8inx 1054 47 few few JJ cord-010092-uftc8inx 1054 48 . . . cord-010092-uftc8inx 1055 1 Summary Summary NNP cord-010092-uftc8inx 1055 2 / / SYM cord-010092-uftc8inx 1055 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 1055 4 : : : cord-010092-uftc8inx 1056 1 These these DT cord-010092-uftc8inx 1056 2 results result NNS cord-010092-uftc8inx 1056 3 show show VBP cord-010092-uftc8inx 1056 4 that that IN cord-010092-uftc8inx 1056 5 mapping mapping NN cord-010092-uftc8inx 1056 6 and and CC cord-010092-uftc8inx 1056 7 assessing assess VBG cord-010092-uftc8inx 1056 8 a a DT cord-010092-uftc8inx 1056 9 blood blood NN cord-010092-uftc8inx 1056 10 bank bank NN cord-010092-uftc8inx 1056 11 's 's POS cord-010092-uftc8inx 1056 12 future future NN cord-010092-uftc8inx 1056 13 using use VBG cord-010092-uftc8inx 1056 14 a a DT cord-010092-uftc8inx 1056 15 multi multi JJ cord-010092-uftc8inx 1056 16 - - JJ cord-010092-uftc8inx 1056 17 disciplinary disciplinary JJ cord-010092-uftc8inx 1056 18 group group NN cord-010092-uftc8inx 1056 19 of of IN cord-010092-uftc8inx 1056 20 experts expert NNS cord-010092-uftc8inx 1056 21 is be VBZ cord-010092-uftc8inx 1056 22 conducive conducive JJ cord-010092-uftc8inx 1056 23 as as IN cord-010092-uftc8inx 1056 24 an an DT cord-010092-uftc8inx 1056 25 effective effective JJ cord-010092-uftc8inx 1056 26 means mean NNS cord-010092-uftc8inx 1056 27 of of IN cord-010092-uftc8inx 1056 28 collection collection NN cord-010092-uftc8inx 1056 29 a a DT cord-010092-uftc8inx 1056 30 diverse diverse JJ cord-010092-uftc8inx 1056 31 range range NN cord-010092-uftc8inx 1056 32 of of IN cord-010092-uftc8inx 1056 33 opportunities opportunity NNS cord-010092-uftc8inx 1056 34 and and CC cord-010092-uftc8inx 1056 35 threats threat NNS cord-010092-uftc8inx 1056 36 . . . cord-010092-uftc8inx 1057 1 This this DT cord-010092-uftc8inx 1057 2 provides provide VBZ cord-010092-uftc8inx 1057 3 an an DT cord-010092-uftc8inx 1057 4 opportunity opportunity NN cord-010092-uftc8inx 1057 5 for for IN cord-010092-uftc8inx 1057 6 blood blood NN cord-010092-uftc8inx 1057 7 bank bank NN cord-010092-uftc8inx 1057 8 management management NN cord-010092-uftc8inx 1057 9 to to TO cord-010092-uftc8inx 1057 10 become become VB cord-010092-uftc8inx 1057 11 proactive proactive JJ cord-010092-uftc8inx 1057 12 towards towards IN cord-010092-uftc8inx 1057 13 these these DT cord-010092-uftc8inx 1057 14 potential potential JJ cord-010092-uftc8inx 1057 15 opportunities opportunity NNS cord-010092-uftc8inx 1057 16 and and CC cord-010092-uftc8inx 1057 17 threats threat NNS cord-010092-uftc8inx 1057 18 and and CC cord-010092-uftc8inx 1057 19 possibly possibly RB cord-010092-uftc8inx 1057 20 evolve evolve VB cord-010092-uftc8inx 1057 21 future future JJ cord-010092-uftc8inx 1057 22 strategies strategy NNS cord-010092-uftc8inx 1057 23 for for IN cord-010092-uftc8inx 1057 24 the the DT cord-010092-uftc8inx 1057 25 organization organization NN cord-010092-uftc8inx 1057 26 . . . cord-010092-uftc8inx 1058 1 showed show VBD cord-010092-uftc8inx 1058 2 that that IN cord-010092-uftc8inx 1058 3 iron iron NN cord-010092-uftc8inx 1058 4 - - HYPH cord-010092-uftc8inx 1058 5 deficient deficient JJ cord-010092-uftc8inx 1058 6 female female JJ cord-010092-uftc8inx 1058 7 blood blood NN cord-010092-uftc8inx 1058 8 donors donor NNS cord-010092-uftc8inx 1058 9 were be VBD cord-010092-uftc8inx 1058 10 more more RBR cord-010092-uftc8inx 1058 11 likely likely JJ cord-010092-uftc8inx 1058 12 to to TO cord-010092-uftc8inx 1058 13 have have VB cord-010092-uftc8inx 1058 14 depressive depressive JJ cord-010092-uftc8inx 1058 15 symptoms symptom NNS cord-010092-uftc8inx 1058 16 than than IN cord-010092-uftc8inx 1058 17 non non JJ cord-010092-uftc8inx 1058 18 - - JJ cord-010092-uftc8inx 1058 19 iron iron JJ cord-010092-uftc8inx 1058 20 deficient deficient JJ cord-010092-uftc8inx 1058 21 female female JJ cord-010092-uftc8inx 1058 22 blood blood NN cord-010092-uftc8inx 1058 23 donors donor NNS cord-010092-uftc8inx 1058 24 . . . cord-010092-uftc8inx 1059 1 Among among IN cord-010092-uftc8inx 1059 2 participants participant NNS cord-010092-uftc8inx 1059 3 with with IN cord-010092-uftc8inx 1059 4 depressive depressive JJ cord-010092-uftc8inx 1059 5 symptoms symptom NNS cord-010092-uftc8inx 1059 6 , , , cord-010092-uftc8inx 1059 7 females female NNS cord-010092-uftc8inx 1059 8 with with IN cord-010092-uftc8inx 1059 9 low low JJ cord-010092-uftc8inx 1059 10 plasma plasma NN cord-010092-uftc8inx 1059 11 ferritin ferritin NN cord-010092-uftc8inx 1059 12 levels level NNS cord-010092-uftc8inx 1059 13 had have VBD cord-010092-uftc8inx 1059 14 significantly significantly RB cord-010092-uftc8inx 1059 15 increased increase VBN cord-010092-uftc8inx 1059 16 odds odd NNS cord-010092-uftc8inx 1059 17 for for IN cord-010092-uftc8inx 1059 18 reporting report VBG cord-010092-uftc8inx 1059 19 a a DT cord-010092-uftc8inx 1059 20 " " `` cord-010092-uftc8inx 1059 21 feeling feeling NN cord-010092-uftc8inx 1059 22 of of IN cord-010092-uftc8inx 1059 23 lacking lack VBG cord-010092-uftc8inx 1059 24 energy energy NN cord-010092-uftc8inx 1059 25 and and CC cord-010092-uftc8inx 1059 26 strength strength NN cord-010092-uftc8inx 1059 27 " " '' cord-010092-uftc8inx 1059 28 ( ( -LRB- cord-010092-uftc8inx 1059 29 OR or CC cord-010092-uftc8inx 1059 30 = = SYM cord-010092-uftc8inx 1059 31 2.11 2.11 CD cord-010092-uftc8inx 1060 1 ; ; : cord-010092-uftc8inx 1060 2 95 95 CD cord-010092-uftc8inx 1060 3 % % NN cord-010092-uftc8inx 1060 4 CI ci NN cord-010092-uftc8inx 1060 5 : : : cord-010092-uftc8inx 1060 6 1.03 1.03 CD cord-010092-uftc8inx 1060 7 - - SYM cord-010092-uftc8inx 1060 8 4.31 4.31 CD cord-010092-uftc8inx 1060 9 ) ) -RRB- cord-010092-uftc8inx 1060 10 . . . cord-010092-uftc8inx 1061 1 As as IN cord-010092-uftc8inx 1061 2 it -PRON- PRP cord-010092-uftc8inx 1061 3 is be VBZ cord-010092-uftc8inx 1061 4 known know VBN cord-010092-uftc8inx 1061 5 that that IN cord-010092-uftc8inx 1061 6 blood blood NN cord-010092-uftc8inx 1061 7 donors donor NNS cord-010092-uftc8inx 1061 8 are be VBP cord-010092-uftc8inx 1061 9 at at IN cord-010092-uftc8inx 1061 10 an an DT cord-010092-uftc8inx 1061 11 increased increase VBN cord-010092-uftc8inx 1061 12 risk risk NN cord-010092-uftc8inx 1061 13 of of IN cord-010092-uftc8inx 1061 14 iron iron NN cord-010092-uftc8inx 1061 15 deficiency deficiency NN cord-010092-uftc8inx 1061 16 , , , cord-010092-uftc8inx 1061 17 it -PRON- PRP cord-010092-uftc8inx 1061 18 is be VBZ cord-010092-uftc8inx 1061 19 important important JJ cord-010092-uftc8inx 1061 20 to to TO cord-010092-uftc8inx 1061 21 determine determine VB cord-010092-uftc8inx 1061 22 whether whether IN cord-010092-uftc8inx 1061 23 those those DT cord-010092-uftc8inx 1061 24 genetically genetically RB cord-010092-uftc8inx 1061 25 predisposed predisposed JJ cord-010092-uftc8inx 1061 26 to to TO cord-010092-uftc8inx 1061 27 lower lower VB cord-010092-uftc8inx 1061 28 plasma plasma NN cord-010092-uftc8inx 1061 29 ferritin ferritin NN cord-010092-uftc8inx 1061 30 levels level NNS cord-010092-uftc8inx 1061 31 have have VBP cord-010092-uftc8inx 1061 32 a a DT cord-010092-uftc8inx 1061 33 higher high JJR cord-010092-uftc8inx 1061 34 risk risk NN cord-010092-uftc8inx 1061 35 of of IN cord-010092-uftc8inx 1061 36 experiencing experience VBG cord-010092-uftc8inx 1061 37 the the DT cord-010092-uftc8inx 1061 38 tiredness tiredness NN cord-010092-uftc8inx 1061 39 / / SYM cord-010092-uftc8inx 1061 40 lack lack NN cord-010092-uftc8inx 1061 41 of of IN cord-010092-uftc8inx 1061 42 energy energy NN cord-010092-uftc8inx 1061 43 symptom symptom NN cord-010092-uftc8inx 1061 44 . . . cord-010092-uftc8inx 1062 1 Aims aim VBZ cord-010092-uftc8inx 1062 2 : : : cord-010092-uftc8inx 1063 1 To to TO cord-010092-uftc8inx 1063 2 investigate investigate VB cord-010092-uftc8inx 1063 3 whether whether IN cord-010092-uftc8inx 1063 4 there there EX cord-010092-uftc8inx 1063 5 is be VBZ cord-010092-uftc8inx 1063 6 an an DT cord-010092-uftc8inx 1063 7 association association NN cord-010092-uftc8inx 1063 8 between between IN cord-010092-uftc8inx 1063 9 polygenic polygenic JJ cord-010092-uftc8inx 1063 10 risk risk NN cord-010092-uftc8inx 1063 11 scores score NNS cord-010092-uftc8inx 1063 12 ( ( -LRB- cord-010092-uftc8inx 1063 13 PRSs prs NNS cord-010092-uftc8inx 1063 14 ) ) -RRB- cord-010092-uftc8inx 1063 15 based base VBN cord-010092-uftc8inx 1063 16 on on IN cord-010092-uftc8inx 1063 17 plasma plasma NN cord-010092-uftc8inx 1063 18 ferritin ferritin NN cord-010092-uftc8inx 1063 19 levels level NNS cord-010092-uftc8inx 1063 20 and and CC cord-010092-uftc8inx 1063 21 the the DT cord-010092-uftc8inx 1063 22 tiredness tiredness NN cord-010092-uftc8inx 1063 23 / / SYM cord-010092-uftc8inx 1063 24 lack lack NN cord-010092-uftc8inx 1063 25 of of IN cord-010092-uftc8inx 1063 26 energy energy NN cord-010092-uftc8inx 1063 27 symptom symptom NN cord-010092-uftc8inx 1063 28 in in IN cord-010092-uftc8inx 1063 29 blood blood NN cord-010092-uftc8inx 1063 30 donors donor NNS cord-010092-uftc8inx 1063 31 . . . cord-010092-uftc8inx 1064 1 Methods method NNS cord-010092-uftc8inx 1064 2 : : : cord-010092-uftc8inx 1064 3 The the DT cord-010092-uftc8inx 1064 4 DBDS DBDS NNP cord-010092-uftc8inx 1064 5 is be VBZ cord-010092-uftc8inx 1064 6 an an DT cord-010092-uftc8inx 1064 7 ongoing ongoing JJ cord-010092-uftc8inx 1064 8 nationwide nationwide JJ cord-010092-uftc8inx 1064 9 blood blood NN cord-010092-uftc8inx 1064 10 donor donor NN cord-010092-uftc8inx 1064 11 cohort cohort NN cord-010092-uftc8inx 1064 12 , , , cord-010092-uftc8inx 1064 13 of of IN cord-010092-uftc8inx 1064 14 which which WDT cord-010092-uftc8inx 1064 15 genome genome NN cord-010092-uftc8inx 1064 16 - - HYPH cord-010092-uftc8inx 1064 17 wide wide JJ cord-010092-uftc8inx 1064 18 genotype genotype NN cord-010092-uftc8inx 1064 19 data datum NNS cord-010092-uftc8inx 1064 20 are be VBP cord-010092-uftc8inx 1064 21 available available JJ cord-010092-uftc8inx 1064 22 for for IN cord-010092-uftc8inx 1064 23 72,000 72,000 CD cord-010092-uftc8inx 1064 24 participants participant NNS cord-010092-uftc8inx 1064 25 . . . cord-010092-uftc8inx 1065 1 Genotyping Genotyping NNP cord-010092-uftc8inx 1065 2 was be VBD cord-010092-uftc8inx 1065 3 performed perform VBN cord-010092-uftc8inx 1065 4 using use VBG cord-010092-uftc8inx 1065 5 the the DT cord-010092-uftc8inx 1065 6 Infinium Infinium NNP cord-010092-uftc8inx 1065 7 Global Global NNP cord-010092-uftc8inx 1065 8 Screening Screening NNP cord-010092-uftc8inx 1065 9 Array Array NNP cord-010092-uftc8inx 1065 10 ( ( -LRB- cord-010092-uftc8inx 1065 11 Illumina Illumina NNP cord-010092-uftc8inx 1065 12 â â CD cord-010092-uftc8inx 1065 13 ) ) -RRB- cord-010092-uftc8inx 1065 14 and and CC cord-010092-uftc8inx 1065 15 imputation imputation NN cord-010092-uftc8inx 1065 16 was be VBD cord-010092-uftc8inx 1065 17 achieved achieve VBN cord-010092-uftc8inx 1065 18 based base VBN cord-010092-uftc8inx 1065 19 on on IN cord-010092-uftc8inx 1065 20 a a DT cord-010092-uftc8inx 1065 21 Scandinavian scandinavian JJ cord-010092-uftc8inx 1065 22 reference reference NN cord-010092-uftc8inx 1065 23 genome genome NN cord-010092-uftc8inx 1065 24 . . . cord-010092-uftc8inx 1066 1 Ferritin ferritin NN cord-010092-uftc8inx 1066 2 PRSs prs NNS cord-010092-uftc8inx 1066 3 , , , cord-010092-uftc8inx 1066 4 based base VBN cord-010092-uftc8inx 1066 5 on on IN cord-010092-uftc8inx 1066 6 an an DT cord-010092-uftc8inx 1066 7 Icelandic icelandic JJ cord-010092-uftc8inx 1066 8 ferritin ferritin NN cord-010092-uftc8inx 1066 9 GWAS GWAS NNP cord-010092-uftc8inx 1066 10 ( ( -LRB- cord-010092-uftc8inx 1066 11 N n NN cord-010092-uftc8inx 1066 12 = = SYM cord-010092-uftc8inx 1066 13 150,000 150,000 CD cord-010092-uftc8inx 1066 14 ) ) -RRB- cord-010092-uftc8inx 1066 15 , , , cord-010092-uftc8inx 1066 16 were be VBD cord-010092-uftc8inx 1066 17 calculated calculate VBN cord-010092-uftc8inx 1066 18 for for IN cord-010092-uftc8inx 1066 19 all all DT cord-010092-uftc8inx 1066 20 DBDS DBDS NNP cord-010092-uftc8inx 1066 21 participants participant NNS cord-010092-uftc8inx 1066 22 . . . cord-010092-uftc8inx 1067 1 12,903 12,903 CD cord-010092-uftc8inx 1067 2 female female JJ cord-010092-uftc8inx 1067 3 donors donor NNS cord-010092-uftc8inx 1067 4 were be VBD cord-010092-uftc8inx 1067 5 available available JJ cord-010092-uftc8inx 1067 6 for for IN cord-010092-uftc8inx 1067 7 the the DT cord-010092-uftc8inx 1067 8 analysis analysis NN cord-010092-uftc8inx 1067 9 . . . cord-010092-uftc8inx 1068 1 Data datum NNS cord-010092-uftc8inx 1068 2 on on IN cord-010092-uftc8inx 1068 3 depressive depressive JJ cord-010092-uftc8inx 1068 4 symptoms symptom NNS cord-010092-uftc8inx 1068 5 were be VBD cord-010092-uftc8inx 1068 6 obtained obtain VBN cord-010092-uftc8inx 1068 7 using use VBG cord-010092-uftc8inx 1068 8 the the DT cord-010092-uftc8inx 1068 9 validated validate VBN cord-010092-uftc8inx 1068 10 Major Major NNP cord-010092-uftc8inx 1068 11 Depression Depression NNP cord-010092-uftc8inx 1068 12 Inventory Inventory NNP cord-010092-uftc8inx 1068 13 scale scale NN cord-010092-uftc8inx 1068 14 ( ( -LRB- cord-010092-uftc8inx 1068 15 MDI MDI NNP cord-010092-uftc8inx 1068 16 ) ) -RRB- cord-010092-uftc8inx 1068 17 , , , cord-010092-uftc8inx 1068 18 a a DT cord-010092-uftc8inx 1068 19 selfreport selfreport NNP cord-010092-uftc8inx 1068 20 mood mood NN cord-010092-uftc8inx 1068 21 questionnaire questionnaire NN cord-010092-uftc8inx 1068 22 , , , cord-010092-uftc8inx 1068 23 which which WDT cord-010092-uftc8inx 1068 24 assesses assess VBZ cord-010092-uftc8inx 1068 25 the the DT cord-010092-uftc8inx 1068 26 presence presence NN cord-010092-uftc8inx 1068 27 of of IN cord-010092-uftc8inx 1068 28 10 10 CD cord-010092-uftc8inx 1068 29 depressive depressive JJ cord-010092-uftc8inx 1068 30 symptoms symptom NNS cord-010092-uftc8inx 1068 31 . . . cord-010092-uftc8inx 1069 1 A a DT cord-010092-uftc8inx 1069 2 donor donor NN cord-010092-uftc8inx 1069 3 was be VBD cord-010092-uftc8inx 1069 4 classified classify VBN cord-010092-uftc8inx 1069 5 as as IN cord-010092-uftc8inx 1069 6 " " `` cord-010092-uftc8inx 1069 7 tired tired JJ cord-010092-uftc8inx 1069 8 " " '' cord-010092-uftc8inx 1069 9 if if IN cord-010092-uftc8inx 1069 10 they -PRON- PRP cord-010092-uftc8inx 1069 11 responded respond VBD cord-010092-uftc8inx 1069 12 " " `` cord-010092-uftc8inx 1069 13 all all PDT cord-010092-uftc8inx 1069 14 the the DT cord-010092-uftc8inx 1069 15 time time NN cord-010092-uftc8inx 1069 16 " " '' cord-010092-uftc8inx 1069 17 or or CC cord-010092-uftc8inx 1069 18 " " `` cord-010092-uftc8inx 1069 19 most most JJS cord-010092-uftc8inx 1069 20 of of IN cord-010092-uftc8inx 1069 21 the the DT cord-010092-uftc8inx 1069 22 time time NN cord-010092-uftc8inx 1069 23 " " '' cord-010092-uftc8inx 1069 24 to to IN cord-010092-uftc8inx 1069 25 the the DT cord-010092-uftc8inx 1069 26 question question NN cord-010092-uftc8inx 1069 27 " " `` cord-010092-uftc8inx 1069 28 how how WRB cord-010092-uftc8inx 1069 29 often often RB cord-010092-uftc8inx 1069 30 do do VBP cord-010092-uftc8inx 1069 31 you -PRON- PRP cord-010092-uftc8inx 1069 32 feel feel VB cord-010092-uftc8inx 1069 33 that that IN cord-010092-uftc8inx 1069 34 you -PRON- PRP cord-010092-uftc8inx 1069 35 lacked lack VBD cord-010092-uftc8inx 1069 36 energy energy NN cord-010092-uftc8inx 1069 37 and and CC cord-010092-uftc8inx 1069 38 strength strength NN cord-010092-uftc8inx 1069 39 ? ? . cord-010092-uftc8inx 1069 40 " " '' cord-010092-uftc8inx 1069 41 . . . cord-010092-uftc8inx 1070 1 Logistic logistic JJ cord-010092-uftc8inx 1070 2 regression regression NN cord-010092-uftc8inx 1070 3 analysis analysis NN cord-010092-uftc8inx 1070 4 was be VBD cord-010092-uftc8inx 1070 5 performed perform VBN cord-010092-uftc8inx 1070 6 , , , cord-010092-uftc8inx 1070 7 adjusting adjust VBG cord-010092-uftc8inx 1070 8 for for IN cord-010092-uftc8inx 1070 9 age age NN cord-010092-uftc8inx 1070 10 . . . cord-010092-uftc8inx 1071 1 For for IN cord-010092-uftc8inx 1071 2 generating generate VBG cord-010092-uftc8inx 1071 3 the the DT cord-010092-uftc8inx 1071 4 quantile quantile NN cord-010092-uftc8inx 1071 5 plots plot NNS cord-010092-uftc8inx 1071 6 , , , cord-010092-uftc8inx 1071 7 the the DT cord-010092-uftc8inx 1071 8 participants participant NNS cord-010092-uftc8inx 1071 9 were be VBD cord-010092-uftc8inx 1071 10 distributed distribute VBN cord-010092-uftc8inx 1071 11 evenly evenly RB cord-010092-uftc8inx 1071 12 into into IN cord-010092-uftc8inx 1071 13 six six CD cord-010092-uftc8inx 1071 14 quantiles quantile NNS cord-010092-uftc8inx 1071 15 based base VBN cord-010092-uftc8inx 1071 16 on on IN cord-010092-uftc8inx 1071 17 their -PRON- PRP$ cord-010092-uftc8inx 1071 18 PRS PRS NNP cord-010092-uftc8inx 1071 19 , , , cord-010092-uftc8inx 1071 20 whereby whereby WRB cord-010092-uftc8inx 1071 21 quantile quantile NNP cord-010092-uftc8inx 1071 22 1 1 CD cord-010092-uftc8inx 1071 23 contained contain VBD cord-010092-uftc8inx 1071 24 the the DT cord-010092-uftc8inx 1071 25 donors donor NNS cord-010092-uftc8inx 1071 26 with with IN cord-010092-uftc8inx 1071 27 the the DT cord-010092-uftc8inx 1071 28 lowest low JJS cord-010092-uftc8inx 1071 29 PRSs prs NNS cord-010092-uftc8inx 1071 30 ( ( -LRB- cord-010092-uftc8inx 1071 31 genetically genetically RB cord-010092-uftc8inx 1071 32 predisposed predisposed JJ cord-010092-uftc8inx 1071 33 to to TO cord-010092-uftc8inx 1071 34 lower lower VB cord-010092-uftc8inx 1071 35 ferritin ferritin NN cord-010092-uftc8inx 1071 36 levels level NNS cord-010092-uftc8inx 1071 37 ) ) -RRB- cord-010092-uftc8inx 1071 38 and and CC cord-010092-uftc8inx 1071 39 was be VBD cord-010092-uftc8inx 1071 40 set set VBN cord-010092-uftc8inx 1071 41 as as IN cord-010092-uftc8inx 1071 42 the the DT cord-010092-uftc8inx 1071 43 reference reference NN cord-010092-uftc8inx 1071 44 quantile quantile NN cord-010092-uftc8inx 1071 45 with with IN cord-010092-uftc8inx 1071 46 OR or NN cord-010092-uftc8inx 1071 47 = = SYM cord-010092-uftc8inx 1071 48 1 1 CD cord-010092-uftc8inx 1071 49 from from IN cord-010092-uftc8inx 1071 50 the the DT cord-010092-uftc8inx 1071 51 age age NN cord-010092-uftc8inx 1071 52 - - HYPH cord-010092-uftc8inx 1071 53 adjusted adjust VBN cord-010092-uftc8inx 1071 54 regression regression NN cord-010092-uftc8inx 1071 55 analysis analysis NN cord-010092-uftc8inx 1071 56 ( ( -LRB- cord-010092-uftc8inx 1071 57 tiredness tiredness NN cord-010092-uftc8inx 1071 58 ~ ~ NFP cord-010092-uftc8inx 1071 59 quantile quantile NN cord-010092-uftc8inx 1071 60 ) ) -RRB- cord-010092-uftc8inx 1071 61 . . . cord-010092-uftc8inx 1072 1 Results result NNS cord-010092-uftc8inx 1072 2 : : : cord-010092-uftc8inx 1072 3 PRSs prs NNS cord-010092-uftc8inx 1072 4 in in IN cord-010092-uftc8inx 1072 5 females female NNS cord-010092-uftc8inx 1072 6 ranged range VBD cord-010092-uftc8inx 1072 7 between between IN cord-010092-uftc8inx 1072 8 -0.42 -0.42 CD cord-010092-uftc8inx 1072 9 and and CC cord-010092-uftc8inx 1072 10 0.50 0.50 CD cord-010092-uftc8inx 1072 11 ( ( -LRB- cord-010092-uftc8inx 1072 12 mean mean VB cord-010092-uftc8inx 1072 13 0.01 0.01 CD cord-010092-uftc8inx 1072 14 ) ) -RRB- cord-010092-uftc8inx 1072 15 . . . cord-010092-uftc8inx 1073 1 A a DT cord-010092-uftc8inx 1073 2 total total NN cord-010092-uftc8inx 1073 3 of of IN cord-010092-uftc8inx 1073 4 12,523 12,523 CD cord-010092-uftc8inx 1073 5 female female JJ cord-010092-uftc8inx 1073 6 donors donor NNS cord-010092-uftc8inx 1073 7 were be VBD cord-010092-uftc8inx 1073 8 classified classify VBN cord-010092-uftc8inx 1073 9 as as IN cord-010092-uftc8inx 1073 10 " " `` cord-010092-uftc8inx 1073 11 not not RB cord-010092-uftc8inx 1073 12 tired tired JJ cord-010092-uftc8inx 1073 13 " " '' cord-010092-uftc8inx 1073 14 and and CC cord-010092-uftc8inx 1073 15 380 380 CD cord-010092-uftc8inx 1073 16 ( ( -LRB- cord-010092-uftc8inx 1073 17 2.9 2.9 CD cord-010092-uftc8inx 1073 18 % % NN cord-010092-uftc8inx 1073 19 ) ) -RRB- cord-010092-uftc8inx 1073 20 were be VBD cord-010092-uftc8inx 1073 21 classified classify VBN cord-010092-uftc8inx 1073 22 as as IN cord-010092-uftc8inx 1073 23 " " `` cord-010092-uftc8inx 1073 24 tired tired JJ cord-010092-uftc8inx 1073 25 " " '' cord-010092-uftc8inx 1073 26 . . . cord-010092-uftc8inx 1074 1 No no DT cord-010092-uftc8inx 1074 2 significant significant JJ cord-010092-uftc8inx 1074 3 difference difference NN cord-010092-uftc8inx 1074 4 in in IN cord-010092-uftc8inx 1074 5 ferritin ferritin NN cord-010092-uftc8inx 1074 6 PRS PRS NNP cord-010092-uftc8inx 1074 7 was be VBD cord-010092-uftc8inx 1074 8 found find VBN cord-010092-uftc8inx 1074 9 between between IN cord-010092-uftc8inx 1074 10 " " `` cord-010092-uftc8inx 1074 11 tired tired JJ cord-010092-uftc8inx 1074 12 " " '' cord-010092-uftc8inx 1074 13 and and CC cord-010092-uftc8inx 1074 14 " " `` cord-010092-uftc8inx 1074 15 not not RB cord-010092-uftc8inx 1074 16 tired tired JJ cord-010092-uftc8inx 1074 17 " " '' cord-010092-uftc8inx 1074 18 female female JJ cord-010092-uftc8inx 1074 19 donors donor NNS cord-010092-uftc8inx 1074 20 ( ( -LRB- cord-010092-uftc8inx 1074 21 tired tired JJ cord-010092-uftc8inx 1074 22 mean mean NN cord-010092-uftc8inx 1074 23 PRS PRS NNP cord-010092-uftc8inx 1074 24 : : : cord-010092-uftc8inx 1074 25 0.00 0.00 CD cord-010092-uftc8inx 1074 26 ; ; : cord-010092-uftc8inx 1074 27 not not RB cord-010092-uftc8inx 1074 28 tired tired JJ cord-010092-uftc8inx 1075 1 mean mean VB cord-010092-uftc8inx 1075 2 PRS PRS NNP cord-010092-uftc8inx 1075 3 : : : cord-010092-uftc8inx 1075 4 0.01 0.01 CD cord-010092-uftc8inx 1075 5 ) ) -RRB- cord-010092-uftc8inx 1075 6 . . . cord-010092-uftc8inx 1076 1 An an DT cord-010092-uftc8inx 1076 2 age age NN cord-010092-uftc8inx 1076 3 - - HYPH cord-010092-uftc8inx 1076 4 adjusted adjust VBN cord-010092-uftc8inx 1076 5 logistic logistic JJ cord-010092-uftc8inx 1076 6 regression regression NN cord-010092-uftc8inx 1076 7 model model NN cord-010092-uftc8inx 1076 8 found find VBD cord-010092-uftc8inx 1076 9 this this DT cord-010092-uftc8inx 1076 10 to to TO cord-010092-uftc8inx 1076 11 be be VB cord-010092-uftc8inx 1076 12 insignificant insignificant JJ cord-010092-uftc8inx 1076 13 ( ( -LRB- cord-010092-uftc8inx 1076 14 OR or CC cord-010092-uftc8inx 1076 15 : : : cord-010092-uftc8inx 1076 16 0.74 0.74 CD cord-010092-uftc8inx 1077 1 , , , cord-010092-uftc8inx 1077 2 95 95 CD cord-010092-uftc8inx 1077 3 % % NN cord-010092-uftc8inx 1077 4 CI ci NN cord-010092-uftc8inx 1077 5 : : : cord-010092-uftc8inx 1077 6 0.33 0.33 CD cord-010092-uftc8inx 1077 7 - - SYM cord-010092-uftc8inx 1077 8 1.66 1.66 CD cord-010092-uftc8inx 1077 9 ) ) -RRB- cord-010092-uftc8inx 1077 10 , , , cord-010092-uftc8inx 1077 11 P p NN cord-010092-uftc8inx 1077 12 = = SYM cord-010092-uftc8inx 1077 13 0.47 0.47 CD cord-010092-uftc8inx 1077 14 ) ) -RRB- cord-010092-uftc8inx 1077 15 . . . cord-010092-uftc8inx 1078 1 To to TO cord-010092-uftc8inx 1078 2 visualise visualise VB cord-010092-uftc8inx 1078 3 the the DT cord-010092-uftc8inx 1078 4 lack lack NN cord-010092-uftc8inx 1078 5 of of IN cord-010092-uftc8inx 1078 6 association association NN cord-010092-uftc8inx 1078 7 , , , cord-010092-uftc8inx 1078 8 a a DT cord-010092-uftc8inx 1078 9 quantile quantile NN cord-010092-uftc8inx 1078 10 plot plot NN cord-010092-uftc8inx 1078 11 was be VBD cord-010092-uftc8inx 1078 12 created create VBN cord-010092-uftc8inx 1078 13 , , , cord-010092-uftc8inx 1078 14 separating separate VBG cord-010092-uftc8inx 1078 15 the the DT cord-010092-uftc8inx 1078 16 female female JJ cord-010092-uftc8inx 1078 17 donors donor NNS cord-010092-uftc8inx 1078 18 into into IN cord-010092-uftc8inx 1078 19 six six CD cord-010092-uftc8inx 1078 20 equal equal JJ cord-010092-uftc8inx 1078 21 quantiles quantile NNS cord-010092-uftc8inx 1078 22 based base VBN cord-010092-uftc8inx 1078 23 on on IN cord-010092-uftc8inx 1078 24 their -PRON- PRP$ cord-010092-uftc8inx 1078 25 PRS PRS NNP cord-010092-uftc8inx 1078 26 . . . cord-010092-uftc8inx 1079 1 No no DT cord-010092-uftc8inx 1079 2 clear clear JJ cord-010092-uftc8inx 1079 3 trend trend NN cord-010092-uftc8inx 1079 4 was be VBD cord-010092-uftc8inx 1079 5 observed observe VBN cord-010092-uftc8inx 1079 6 ; ; : cord-010092-uftc8inx 1079 7 donors donor NNS cord-010092-uftc8inx 1079 8 with with IN cord-010092-uftc8inx 1079 9 the the DT cord-010092-uftc8inx 1079 10 highest high JJS cord-010092-uftc8inx 1079 11 PRSs prs NNS cord-010092-uftc8inx 1079 12 ( ( -LRB- cord-010092-uftc8inx 1079 13 in in IN cord-010092-uftc8inx 1079 14 quantile quantile NNP cord-010092-uftc8inx 1079 15 6 6 CD cord-010092-uftc8inx 1079 16 ) ) -RRB- cord-010092-uftc8inx 1079 17 had have VBD cord-010092-uftc8inx 1080 1 OR or CC cord-010092-uftc8inx 1081 1 = = NFP cord-010092-uftc8inx 1081 2 1.02 1.02 CD cord-010092-uftc8inx 1082 1 ( ( -LRB- cord-010092-uftc8inx 1082 2 P p NN cord-010092-uftc8inx 1082 3 = = SYM cord-010092-uftc8inx 1082 4 0.93 0.93 CD cord-010092-uftc8inx 1082 5 ) ) -RRB- cord-010092-uftc8inx 1082 6 of of IN cord-010092-uftc8inx 1082 7 being be VBG cord-010092-uftc8inx 1082 8 tired tired JJ cord-010092-uftc8inx 1082 9 when when WRB cord-010092-uftc8inx 1082 10 compared compare VBN cord-010092-uftc8inx 1082 11 to to IN cord-010092-uftc8inx 1082 12 those those DT cord-010092-uftc8inx 1082 13 in in IN cord-010092-uftc8inx 1082 14 quantile quantile NN cord-010092-uftc8inx 1082 15 1 1 CD cord-010092-uftc8inx 1082 16 ( ( -LRB- cord-010092-uftc8inx 1082 17 OR or CC cord-010092-uftc8inx 1082 18 set set VBN cord-010092-uftc8inx 1082 19 as as IN cord-010092-uftc8inx 1082 20 1 1 CD cord-010092-uftc8inx 1082 21 ) ) -RRB- cord-010092-uftc8inx 1082 22 . . . cord-010092-uftc8inx 1083 1 Summary Summary NNP cord-010092-uftc8inx 1083 2 / / SYM cord-010092-uftc8inx 1083 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 1083 4 : : : cord-010092-uftc8inx 1084 1 No no DT cord-010092-uftc8inx 1084 2 significant significant JJ cord-010092-uftc8inx 1084 3 association association NN cord-010092-uftc8inx 1084 4 was be VBD cord-010092-uftc8inx 1084 5 found find VBN cord-010092-uftc8inx 1084 6 between between IN cord-010092-uftc8inx 1084 7 the the DT cord-010092-uftc8inx 1084 8 ferritin ferritin NN cord-010092-uftc8inx 1084 9 PRSs prs NNS cord-010092-uftc8inx 1084 10 of of IN cord-010092-uftc8inx 1084 11 female female JJ cord-010092-uftc8inx 1084 12 blood blood NN cord-010092-uftc8inx 1084 13 donors donor NNS cord-010092-uftc8inx 1084 14 and and CC cord-010092-uftc8inx 1084 15 the the DT cord-010092-uftc8inx 1084 16 tiredness tiredness NN cord-010092-uftc8inx 1084 17 / / SYM cord-010092-uftc8inx 1084 18 lack lack NN cord-010092-uftc8inx 1084 19 of of IN cord-010092-uftc8inx 1084 20 energy energy NN cord-010092-uftc8inx 1084 21 symptom symptom NN cord-010092-uftc8inx 1084 22 . . . cord-010092-uftc8inx 1085 1 Further further JJ cord-010092-uftc8inx 1085 2 studies study NNS cord-010092-uftc8inx 1085 3 are be VBP cord-010092-uftc8inx 1085 4 needed need VBN cord-010092-uftc8inx 1085 5 to to TO cord-010092-uftc8inx 1085 6 understand understand VB cord-010092-uftc8inx 1085 7 the the DT cord-010092-uftc8inx 1085 8 effect effect NN cord-010092-uftc8inx 1085 9 of of IN cord-010092-uftc8inx 1085 10 blood blood NN cord-010092-uftc8inx 1085 11 donation donation NN cord-010092-uftc8inx 1085 12 versus versus IN cord-010092-uftc8inx 1085 13 genetic genetic JJ cord-010092-uftc8inx 1085 14 constitution constitution NN cord-010092-uftc8inx 1085 15 on on IN cord-010092-uftc8inx 1085 16 tiredness tiredness NN cord-010092-uftc8inx 1085 17 among among IN cord-010092-uftc8inx 1085 18 female female JJ cord-010092-uftc8inx 1085 19 iron iron NN cord-010092-uftc8inx 1085 20 - - HYPH cord-010092-uftc8inx 1085 21 deficient deficient JJ cord-010092-uftc8inx 1085 22 blood blood NN cord-010092-uftc8inx 1085 23 donors donor NNS cord-010092-uftc8inx 1085 24 . . . cord-010092-uftc8inx 1086 1 Background background NN cord-010092-uftc8inx 1086 2 : : : cord-010092-uftc8inx 1087 1 Antiretroviral Antiretroviral NNP cord-010092-uftc8inx 1087 2 therapy therapy NN cord-010092-uftc8inx 1087 3 ( ( -LRB- cord-010092-uftc8inx 1087 4 ART art NN cord-010092-uftc8inx 1087 5 ) ) -RRB- cord-010092-uftc8inx 1087 6 is be VBZ cord-010092-uftc8inx 1087 7 critical critical JJ cord-010092-uftc8inx 1087 8 for for IN cord-010092-uftc8inx 1087 9 the the DT cord-010092-uftc8inx 1087 10 control control NN cord-010092-uftc8inx 1087 11 of of IN cord-010092-uftc8inx 1087 12 clinical clinical JJ cord-010092-uftc8inx 1087 13 progression progression NN cord-010092-uftc8inx 1087 14 of of IN cord-010092-uftc8inx 1087 15 human human JJ cord-010092-uftc8inx 1087 16 immunodeficiency immunodeficiency NN cord-010092-uftc8inx 1087 17 virus virus NN cord-010092-uftc8inx 1087 18 ( ( -LRB- cord-010092-uftc8inx 1087 19 HIV HIV NNP cord-010092-uftc8inx 1087 20 ) ) -RRB- cord-010092-uftc8inx 1087 21 infections infection NNS cord-010092-uftc8inx 1087 22 . . . cord-010092-uftc8inx 1088 1 However however RB cord-010092-uftc8inx 1088 2 , , , cord-010092-uftc8inx 1088 3 the the DT cord-010092-uftc8inx 1088 4 outcome outcome NN cord-010092-uftc8inx 1088 5 of of IN cord-010092-uftc8inx 1088 6 ART art NN cord-010092-uftc8inx 1088 7 could could MD cord-010092-uftc8inx 1088 8 be be VB cord-010092-uftc8inx 1088 9 limited limit VBN cord-010092-uftc8inx 1088 10 by by IN cord-010092-uftc8inx 1088 11 drug drug NN cord-010092-uftc8inx 1088 12 resistance resistance NN cord-010092-uftc8inx 1088 13 - - HYPH cord-010092-uftc8inx 1088 14 associated associate VBN cord-010092-uftc8inx 1088 15 mutations mutation NNS cord-010092-uftc8inx 1088 16 ( ( -LRB- cord-010092-uftc8inx 1088 17 DRMs DRMs NNP cord-010092-uftc8inx 1088 18 ) ) -RRB- cord-010092-uftc8inx 1088 19 , , , cord-010092-uftc8inx 1088 20 even even RB cord-010092-uftc8inx 1088 21 lead lead VB cord-010092-uftc8inx 1088 22 to to IN cord-010092-uftc8inx 1088 23 the the DT cord-010092-uftc8inx 1088 24 transmission transmission NN cord-010092-uftc8inx 1088 25 of of IN cord-010092-uftc8inx 1088 26 drug drug NN cord-010092-uftc8inx 1088 27 - - HYPH cord-010092-uftc8inx 1088 28 resistant resistant JJ cord-010092-uftc8inx 1088 29 HIV HIV NNP cord-010092-uftc8inx 1088 30 to to IN cord-010092-uftc8inx 1088 31 treatment treatment NN cord-010092-uftc8inx 1088 32 na€ na€ NNS cord-010092-uftc8inx 1088 33 ıve ıve JJ cord-010092-uftc8inx 1088 34 patients patient NNS cord-010092-uftc8inx 1088 35 such such JJ cord-010092-uftc8inx 1088 36 as as IN cord-010092-uftc8inx 1088 37 blood blood NN cord-010092-uftc8inx 1088 38 donors donor NNS cord-010092-uftc8inx 1088 39 , , , cord-010092-uftc8inx 1088 40 which which WDT cord-010092-uftc8inx 1088 41 is be VBZ cord-010092-uftc8inx 1088 42 a a DT cord-010092-uftc8inx 1088 43 huge huge JJ cord-010092-uftc8inx 1088 44 concern concern NN cord-010092-uftc8inx 1088 45 to to IN cord-010092-uftc8inx 1088 46 ART art NN cord-010092-uftc8inx 1088 47 . . . cord-010092-uftc8inx 1089 1 DRMs DRMs NNP cord-010092-uftc8inx 1089 2 surveillance surveillance NN cord-010092-uftc8inx 1089 3 in in IN cord-010092-uftc8inx 1089 4 HIV HIV NNP cord-010092-uftc8inx 1089 5 infected infect VBN cord-010092-uftc8inx 1089 6 groups group NNS cord-010092-uftc8inx 1089 7 is be VBZ cord-010092-uftc8inx 1089 8 strongly strongly RB cord-010092-uftc8inx 1089 9 recommended recommend VBN cord-010092-uftc8inx 1089 10 by by IN cord-010092-uftc8inx 1089 11 World World NNP cord-010092-uftc8inx 1089 12 Health Health NNP cord-010092-uftc8inx 1089 13 Organization Organization NNP cord-010092-uftc8inx 1089 14 . . . cord-010092-uftc8inx 1090 1 Characteristics characteristic NNS cord-010092-uftc8inx 1090 2 of of IN cord-010092-uftc8inx 1090 3 genetic genetic JJ cord-010092-uftc8inx 1090 4 diversity diversity NN cord-010092-uftc8inx 1090 5 and and CC cord-010092-uftc8inx 1090 6 DRMs drm NNS cord-010092-uftc8inx 1090 7 of of IN cord-010092-uftc8inx 1090 8 HIV HIV NNP cord-010092-uftc8inx 1090 9 among among IN cord-010092-uftc8inx 1090 10 blood blood NN cord-010092-uftc8inx 1090 11 donors donor NNS cord-010092-uftc8inx 1090 12 may may MD cord-010092-uftc8inx 1090 13 provide provide VB cord-010092-uftc8inx 1090 14 comprehensive comprehensive JJ cord-010092-uftc8inx 1090 15 data datum NNS cord-010092-uftc8inx 1090 16 to to TO cord-010092-uftc8inx 1090 17 monitor monitor VB cord-010092-uftc8inx 1090 18 viral viral JJ cord-010092-uftc8inx 1090 19 evolution evolution NN cord-010092-uftc8inx 1090 20 and and CC cord-010092-uftc8inx 1090 21 optimize optimize VB cord-010092-uftc8inx 1090 22 ART art NN cord-010092-uftc8inx 1090 23 , , , cord-010092-uftc8inx 1090 24 play play VB cord-010092-uftc8inx 1090 25 important important JJ cord-010092-uftc8inx 1090 26 roles role NNS cord-010092-uftc8inx 1090 27 in in IN cord-010092-uftc8inx 1090 28 blood blood NN cord-010092-uftc8inx 1090 29 safety safety NN cord-010092-uftc8inx 1090 30 . . . cord-010092-uftc8inx 1091 1 Aims aim VBZ cord-010092-uftc8inx 1091 2 : : : cord-010092-uftc8inx 1091 3 Limited limited JJ cord-010092-uftc8inx 1091 4 data datum NNS cord-010092-uftc8inx 1091 5 concerning concern VBG cord-010092-uftc8inx 1091 6 the the DT cord-010092-uftc8inx 1091 7 epidemic epidemic NN cord-010092-uftc8inx 1091 8 of of IN cord-010092-uftc8inx 1091 9 HIV-1 HIV-1 NNP cord-010092-uftc8inx 1091 10 subtypes subtype NNS cord-010092-uftc8inx 1091 11 and and CC cord-010092-uftc8inx 1091 12 DRMs drm NNS cord-010092-uftc8inx 1091 13 of of IN cord-010092-uftc8inx 1091 14 blood blood NN cord-010092-uftc8inx 1091 15 donors donor NNS cord-010092-uftc8inx 1091 16 is be VBZ cord-010092-uftc8inx 1091 17 available available JJ cord-010092-uftc8inx 1091 18 in in IN cord-010092-uftc8inx 1091 19 China China NNP cord-010092-uftc8inx 1091 20 . . . cord-010092-uftc8inx 1092 1 This this DT cord-010092-uftc8inx 1092 2 study study NN cord-010092-uftc8inx 1092 3 is be VBZ cord-010092-uftc8inx 1092 4 to to TO cord-010092-uftc8inx 1092 5 investigate investigate VB cord-010092-uftc8inx 1092 6 genetic genetic JJ cord-010092-uftc8inx 1092 7 characteristics characteristic NNS cord-010092-uftc8inx 1092 8 and and CC cord-010092-uftc8inx 1092 9 DRMs drm NNS cord-010092-uftc8inx 1092 10 of of IN cord-010092-uftc8inx 1092 11 HIV-1 HIV-1 NNP cord-010092-uftc8inx 1092 12 infected infect VBD cord-010092-uftc8inx 1092 13 blood blood NN cord-010092-uftc8inx 1092 14 donors donor NNS cord-010092-uftc8inx 1092 15 . . . cord-010092-uftc8inx 1093 1 Methods method NNS cord-010092-uftc8inx 1093 2 : : : cord-010092-uftc8inx 1094 1 From from IN cord-010092-uftc8inx 1094 2 2016 2016 CD cord-010092-uftc8inx 1094 3 - - SYM cord-010092-uftc8inx 1094 4 2018 2018 CD cord-010092-uftc8inx 1094 5 , , , cord-010092-uftc8inx 1094 6 177 177 CD cord-010092-uftc8inx 1094 7 blood blood NN cord-010092-uftc8inx 1094 8 donations donation NNS cord-010092-uftc8inx 1094 9 collected collect VBN cord-010092-uftc8inx 1094 10 from from IN cord-010092-uftc8inx 1094 11 24 24 CD cord-010092-uftc8inx 1094 12 blood blood NN cord-010092-uftc8inx 1094 13 centers center NNS cord-010092-uftc8inx 1094 14 , , , cord-010092-uftc8inx 1094 15 covering cover VBG cord-010092-uftc8inx 1094 16 almost almost RB cord-010092-uftc8inx 1094 17 the the DT cord-010092-uftc8inx 1094 18 whole whole NN cord-010092-uftc8inx 1094 19 of of IN cord-010092-uftc8inx 1094 20 China China NNP cord-010092-uftc8inx 1094 21 , , , cord-010092-uftc8inx 1094 22 were be VBD cord-010092-uftc8inx 1094 23 confirmed confirm VBN cord-010092-uftc8inx 1094 24 as as IN cord-010092-uftc8inx 1094 25 HIV-1 HIV-1 NNP cord-010092-uftc8inx 1094 26 positive positive JJ cord-010092-uftc8inx 1094 27 by by IN cord-010092-uftc8inx 1094 28 National National NNP cord-010092-uftc8inx 1094 29 Centers Centers NNPS cord-010092-uftc8inx 1094 30 for for IN cord-010092-uftc8inx 1094 31 Clinical Clinical NNP cord-010092-uftc8inx 1094 32 Laboratories Laboratories NNPS cord-010092-uftc8inx 1094 33 using use VBG cord-010092-uftc8inx 1094 34 Abbott Abbott NNP cord-010092-uftc8inx 1094 35 RealTime RealTime NNP cord-010092-uftc8inx 1094 36 HIV-1 HIV-1 NNP cord-010092-uftc8inx 1094 37 assay assay NN cord-010092-uftc8inx 1094 38 or or CC cord-010092-uftc8inx 1094 39 COBAS COBAS NNP cord-010092-uftc8inx 1094 40 Taq Taq NNP cord-010092-uftc8inx 1094 41 - - HYPH cord-010092-uftc8inx 1094 42 Man Man NNP cord-010092-uftc8inx 1094 43 HIV-1 HIV-1 NNP cord-010092-uftc8inx 1094 44 Test Test NNP cord-010092-uftc8inx 1094 45 , , , cord-010092-uftc8inx 1094 46 version version NN cord-010092-uftc8inx 1094 47 2.0 2.0 CD cord-010092-uftc8inx 1094 48 . . . cord-010092-uftc8inx 1095 1 Then then RB cord-010092-uftc8inx 1095 2 HIV-1 HIV-1 NNP cord-010092-uftc8inx 1095 3 Gag Gag NNP cord-010092-uftc8inx 1095 4 ( ( -LRB- cord-010092-uftc8inx 1095 5 973 973 CD cord-010092-uftc8inx 1095 6 bp bp NNP cord-010092-uftc8inx 1095 7 , , , cord-010092-uftc8inx 1095 8 HXB2 HXB2 NNP cord-010092-uftc8inx 1095 9 : : : cord-010092-uftc8inx 1095 10 1074 1074 CD cord-010092-uftc8inx 1095 11 - - HYPH cord-010092-uftc8inx 1095 12 2044 2044 CD cord-010092-uftc8inx 1095 13 ) ) -RRB- cord-010092-uftc8inx 1095 14 , , , cord-010092-uftc8inx 1095 15 pol pol NN cord-010092-uftc8inx 1095 16 genes gene NNS cord-010092-uftc8inx 1095 17 ( ( -LRB- cord-010092-uftc8inx 1095 18 1454 1454 CD cord-010092-uftc8inx 1095 19 bp bp NNP cord-010092-uftc8inx 1095 20 , , , cord-010092-uftc8inx 1095 21 HXB2 HXB2 NNP cord-010092-uftc8inx 1095 22 : : : cord-010092-uftc8inx 1095 23 2068 2068 CD cord-010092-uftc8inx 1095 24 - - HYPH cord-010092-uftc8inx 1095 25 3521 3521 CD cord-010092-uftc8inx 1095 26 ) ) -RRB- cord-010092-uftc8inx 1095 27 ( ( -LRB- cord-010092-uftc8inx 1095 28 encoding encode VBG cord-010092-uftc8inx 1095 29 the the DT cord-010092-uftc8inx 1095 30 whole whole JJ cord-010092-uftc8inx 1095 31 protease protease NN cord-010092-uftc8inx 1095 32 ( ( -LRB- cord-010092-uftc8inx 1095 33 PR PR NNP cord-010092-uftc8inx 1095 34 ) ) -RRB- cord-010092-uftc8inx 1095 35 and and CC cord-010092-uftc8inx 1095 36 a a DT cord-010092-uftc8inx 1095 37 part part NN cord-010092-uftc8inx 1095 38 of of IN cord-010092-uftc8inx 1095 39 reverse reverse JJ cord-010092-uftc8inx 1095 40 transcriptase transcriptase NN cord-010092-uftc8inx 1095 41 ( ( -LRB- cord-010092-uftc8inx 1095 42 RT RT NNP cord-010092-uftc8inx 1095 43 ) ) -RRB- cord-010092-uftc8inx 1095 44 ) ) -RRB- cord-010092-uftc8inx 1095 45 was be VBD cord-010092-uftc8inx 1095 46 sequenced sequence VBN cord-010092-uftc8inx 1095 47 after after IN cord-010092-uftc8inx 1095 48 viral viral JJ cord-010092-uftc8inx 1095 49 RNA RNA NNP cord-010092-uftc8inx 1095 50 extraction extraction NN cord-010092-uftc8inx 1095 51 and and CC cord-010092-uftc8inx 1095 52 amplification amplification NN cord-010092-uftc8inx 1095 53 . . . cord-010092-uftc8inx 1096 1 HIV-1 HIV-1 NNP cord-010092-uftc8inx 1096 2 subtype subtype NN cord-010092-uftc8inx 1096 3 based base VBN cord-010092-uftc8inx 1096 4 on on IN cord-010092-uftc8inx 1096 5 Gag Gag NNP cord-010092-uftc8inx 1096 6 and and CC cord-010092-uftc8inx 1096 7 PR PR NNP cord-010092-uftc8inx 1096 8 - - HYPH cord-010092-uftc8inx 1096 9 RT RT NNP cord-010092-uftc8inx 1096 10 regions region NNS cord-010092-uftc8inx 1096 11 was be VBD cord-010092-uftc8inx 1096 12 determined determine VBN cord-010092-uftc8inx 1096 13 by by IN cord-010092-uftc8inx 1096 14 comprehensive comprehensive JJ cord-010092-uftc8inx 1096 15 analyses analysis NNS cord-010092-uftc8inx 1096 16 of of IN cord-010092-uftc8inx 1096 17 Los Los NNP cord-010092-uftc8inx 1096 18 Alamos Alamos NNP cord-010092-uftc8inx 1096 19 HIV HIV NNP cord-010092-uftc8inx 1096 20 BLAST blast NN cord-010092-uftc8inx 1096 21 tool tool NN cord-010092-uftc8inx 1096 22 , , , cord-010092-uftc8inx 1096 23 REGA REGA NNP cord-010092-uftc8inx 1096 24 HIV-1 HIV-1 NNP cord-010092-uftc8inx 1096 25 Subtyping Subtyping NNP cord-010092-uftc8inx 1096 26 Tool Tool NNP cord-010092-uftc8inx 1096 27 , , , cord-010092-uftc8inx 1096 28 phylogenetic phylogenetic JJ cord-010092-uftc8inx 1096 29 trees tree NNS cord-010092-uftc8inx 1096 30 and and CC cord-010092-uftc8inx 1096 31 online online JJ cord-010092-uftc8inx 1096 32 jpHMM jpHMM NNP cord-010092-uftc8inx 1096 33 program program NN cord-010092-uftc8inx 1096 34 . . . cord-010092-uftc8inx 1097 1 DRMs DRMs NNP cord-010092-uftc8inx 1097 2 analysis analysis NN cord-010092-uftc8inx 1097 3 was be VBD cord-010092-uftc8inx 1097 4 performed perform VBN cord-010092-uftc8inx 1097 5 in in IN cord-010092-uftc8inx 1097 6 the the DT cord-010092-uftc8inx 1097 7 Stanford Stanford NNP cord-010092-uftc8inx 1097 8 HIV HIV NNP cord-010092-uftc8inx 1097 9 Drug Drug NNP cord-010092-uftc8inx 1097 10 Resistance Resistance NNP cord-010092-uftc8inx 1097 11 Database Database NNP cord-010092-uftc8inx 1097 12 . . . cord-010092-uftc8inx 1098 1 Results result NNS cord-010092-uftc8inx 1098 2 : : : cord-010092-uftc8inx 1099 1 Among among IN cord-010092-uftc8inx 1099 2 177 177 CD cord-010092-uftc8inx 1099 3 donations donation NNS cord-010092-uftc8inx 1099 4 , , , cord-010092-uftc8inx 1099 5 Gag Gag NNP cord-010092-uftc8inx 1099 6 and and CC cord-010092-uftc8inx 1099 7 PR PR NNP cord-010092-uftc8inx 1099 8 - - HYPH cord-010092-uftc8inx 1099 9 RT RT NNP cord-010092-uftc8inx 1099 10 regions region NNS cord-010092-uftc8inx 1099 11 of of IN cord-010092-uftc8inx 1099 12 160 160 CD cord-010092-uftc8inx 1099 13 samples sample NNS cord-010092-uftc8inx 1099 14 were be VBD cord-010092-uftc8inx 1099 15 sequenced sequence VBN cord-010092-uftc8inx 1099 16 successfully successfully RB cord-010092-uftc8inx 1099 17 . . . cord-010092-uftc8inx 1100 1 The the DT cord-010092-uftc8inx 1100 2 distribution distribution NN cord-010092-uftc8inx 1100 3 of of IN cord-010092-uftc8inx 1100 4 HIV-1 HIV-1 NNP cord-010092-uftc8inx 1100 5 genotype genotype NN cord-010092-uftc8inx 1100 6 was be VBD cord-010092-uftc8inx 1100 7 as as IN cord-010092-uftc8inx 1100 8 follows follow VBZ cord-010092-uftc8inx 1100 9 : : : cord-010092-uftc8inx 1101 1 CRF_07BC CRF_07BC NNP cord-010092-uftc8inx 1102 1 = = SYM cord-010092-uftc8inx 1102 2 66 66 CD cord-010092-uftc8inx 1102 3 ( ( -LRB- cord-010092-uftc8inx 1102 4 38.8 38.8 CD cord-010092-uftc8inx 1102 5 % % NN cord-010092-uftc8inx 1102 6 ) ) -RRB- cord-010092-uftc8inx 1103 1 , , , cord-010092-uftc8inx 1103 2 CRF_01AE crf_01ae CD cord-010092-uftc8inx 1103 3 = = SYM cord-010092-uftc8inx 1103 4 58 58 CD cord-010092-uftc8inx 1103 5 ( ( -LRB- cord-010092-uftc8inx 1103 6 36.3 36.3 CD cord-010092-uftc8inx 1103 7 % % NN cord-010092-uftc8inx 1103 8 ) ) -RRB- cord-010092-uftc8inx 1103 9 , , . cord-010092-uftc8inx 1104 1 B b NN cord-010092-uftc8inx 1104 2 = = SYM cord-010092-uftc8inx 1104 3 9 9 CD cord-010092-uftc8inx 1104 4 ( ( -LRB- cord-010092-uftc8inx 1104 5 5.6 5.6 CD cord-010092-uftc8inx 1104 6 % % NN cord-010092-uftc8inx 1104 7 ) ) -RRB- cord-010092-uftc8inx 1104 8 , , . cord-010092-uftc8inx 1105 1 CRF_08BC crf_08bc NN cord-010092-uftc8inx 1105 2 = = SYM cord-010092-uftc8inx 1105 3 2 2 CD cord-010092-uftc8inx 1105 4 ( ( -LRB- cord-010092-uftc8inx 1105 5 1.3 1.3 CD cord-010092-uftc8inx 1105 6 % % NN cord-010092-uftc8inx 1105 7 ) ) -RRB- cord-010092-uftc8inx 1105 8 , , . cord-010092-uftc8inx 1106 1 CRF55_01B crf55_01b NN cord-010092-uftc8inx 1106 2 = = SYM cord-010092-uftc8inx 1106 3 4 4 CD cord-010092-uftc8inx 1106 4 ( ( -LRB- cord-010092-uftc8inx 1106 5 2.5 2.5 CD cord-010092-uftc8inx 1106 6 % % NN cord-010092-uftc8inx 1106 7 ) ) -RRB- cord-010092-uftc8inx 1106 8 , , . cord-010092-uftc8inx 1107 1 CRF59_01B crf59_01b NN cord-010092-uftc8inx 1107 2 = = SYM cord-010092-uftc8inx 1107 3 1 1 CD cord-010092-uftc8inx 1107 4 ( ( -LRB- cord-010092-uftc8inx 1107 5 0.6 0.6 CD cord-010092-uftc8inx 1107 6 % % NN cord-010092-uftc8inx 1107 7 ) ) -RRB- cord-010092-uftc8inx 1107 8 , , , cord-010092-uftc8inx 1107 9 CRF65_cpx CRF65_cpx NNP cord-010092-uftc8inx 1107 10 = = SYM cord-010092-uftc8inx 1107 11 1 1 CD cord-010092-uftc8inx 1107 12 ( ( -LRB- cord-010092-uftc8inx 1107 13 0.6 0.6 CD cord-010092-uftc8inx 1107 14 % % NN cord-010092-uftc8inx 1107 15 ) ) -RRB- cord-010092-uftc8inx 1107 16 , , . cord-010092-uftc8inx 1108 1 CRF67_01B CRF67_01B NNP cord-010092-uftc8inx 1109 1 = = SYM cord-010092-uftc8inx 1109 2 2 2 CD cord-010092-uftc8inx 1109 3 ( ( -LRB- cord-010092-uftc8inx 1109 4 1.3 1.3 CD cord-010092-uftc8inx 1109 5 % % NN cord-010092-uftc8inx 1109 6 ) ) -RRB- cord-010092-uftc8inx 1109 7 , , . cord-010092-uftc8inx 1110 1 CRF79_0107 CRF79_0107 NNP cord-010092-uftc8inx 1110 2 = = SYM cord-010092-uftc8inx 1110 3 1 1 CD cord-010092-uftc8inx 1110 4 ( ( -LRB- cord-010092-uftc8inx 1110 5 0.6 0.6 CD cord-010092-uftc8inx 1110 6 % % NN cord-010092-uftc8inx 1110 7 ) ) -RRB- cord-010092-uftc8inx 1111 1 , , , cord-010092-uftc8inx 1111 2 CRF85_BC CRF85_BC NNP cord-010092-uftc8inx 1111 3 = = SYM cord-010092-uftc8inx 1111 4 1 1 CD cord-010092-uftc8inx 1111 5 ( ( -LRB- cord-010092-uftc8inx 1111 6 0.6 0.6 CD cord-010092-uftc8inx 1111 7 % % NN cord-010092-uftc8inx 1111 8 ) ) -RRB- cord-010092-uftc8inx 1111 9 , , , cord-010092-uftc8inx 1111 10 URF_0107 urf_0107 NN cord-010092-uftc8inx 1111 11 = = SYM cord-010092-uftc8inx 1111 12 6 6 CD cord-010092-uftc8inx 1111 13 ( ( -LRB- cord-010092-uftc8inx 1111 14 3.8 3.8 CD cord-010092-uftc8inx 1111 15 % % NN cord-010092-uftc8inx 1111 16 ) ) -RRB- cord-010092-uftc8inx 1111 17 and and CC cord-010092-uftc8inx 1111 18 URF URF NNP cord-010092-uftc8inx 1111 19 = = SYM cord-010092-uftc8inx 1111 20 9 9 CD cord-010092-uftc8inx 1111 21 ( ( -LRB- cord-010092-uftc8inx 1111 22 5.6 5.6 CD cord-010092-uftc8inx 1111 23 % % NN cord-010092-uftc8inx 1111 24 ) ) -RRB- cord-010092-uftc8inx 1111 25 . . . cord-010092-uftc8inx 1112 1 26 26 CD cord-010092-uftc8inx 1112 2 of of IN cord-010092-uftc8inx 1112 3 160 160 CD cord-010092-uftc8inx 1112 4 HIV-1 HIV-1 NNP cord-010092-uftc8inx 1112 5 isolates isolate NNS cord-010092-uftc8inx 1112 6 were be VBD cord-010092-uftc8inx 1112 7 identified identify VBN cord-010092-uftc8inx 1112 8 to to TO cord-010092-uftc8inx 1112 9 have have VB cord-010092-uftc8inx 1112 10 DRMs drm NNS cord-010092-uftc8inx 1112 11 . . . cord-010092-uftc8inx 1113 1 There there EX cord-010092-uftc8inx 1113 2 were be VBD cord-010092-uftc8inx 1113 3 4 4 CD cord-010092-uftc8inx 1113 4 ( ( -LRB- cord-010092-uftc8inx 1113 5 15.4 15.4 CD cord-010092-uftc8inx 1113 6 % % NN cord-010092-uftc8inx 1113 7 , , , cord-010092-uftc8inx 1113 8 4/26 4/26 CD cord-010092-uftc8inx 1113 9 ) ) -RRB- cord-010092-uftc8inx 1114 1 Protease Protease NNP cord-010092-uftc8inx 1114 2 Inhibitors Inhibitors NNP cord-010092-uftc8inx 1114 3 ( ( -LRB- cord-010092-uftc8inx 1114 4 PI PI NNP cord-010092-uftc8inx 1114 5 ) ) -RRB- cord-010092-uftc8inx 1114 6 accessory accessory NN cord-010092-uftc8inx 1114 7 DRMs drm NNS cord-010092-uftc8inx 1114 8 , , , cord-010092-uftc8inx 1114 9 3 3 CD cord-010092-uftc8inx 1114 10 PI pi NN cord-010092-uftc8inx 1114 11 major major JJ cord-010092-uftc8inx 1114 12 DRMs drm NNS cord-010092-uftc8inx 1114 13 and and CC cord-010092-uftc8inx 1114 14 20 20 CD cord-010092-uftc8inx 1114 15 ( ( -LRB- cord-010092-uftc8inx 1114 16 76.9 76.9 CD cord-010092-uftc8inx 1114 17 % % NN cord-010092-uftc8inx 1114 18 , , , cord-010092-uftc8inx 1114 19 20/26 20/26 CD cord-010092-uftc8inx 1114 20 ) ) -RRB- cord-010092-uftc8inx 1114 21 Non non NN cord-010092-uftc8inx 1114 22 - - NN cord-010092-uftc8inx 1114 23 nucleoside nucleoside JJ cord-010092-uftc8inx 1114 24 Reverse Reverse NNP cord-010092-uftc8inx 1114 25 Transcriptase Transcriptase NNP cord-010092-uftc8inx 1114 26 Inhibitors Inhibitors NNP cord-010092-uftc8inx 1114 27 ( ( -LRB- cord-010092-uftc8inx 1114 28 NNRTI NNRTI NNP cord-010092-uftc8inx 1114 29 ) ) -RRB- cord-010092-uftc8inx 1114 30 DRMs drm NNS cord-010092-uftc8inx 1114 31 . . . cord-010092-uftc8inx 1115 1 Most Most JJS cord-010092-uftc8inx 1115 2 of of IN cord-010092-uftc8inx 1115 3 blood blood NN cord-010092-uftc8inx 1115 4 donors donor NNS cord-010092-uftc8inx 1115 5 with with IN cord-010092-uftc8inx 1115 6 DRMs drm NNS cord-010092-uftc8inx 1115 7 were be VBD cord-010092-uftc8inx 1115 8 CRF01_AE CRF01_AE NNP cord-010092-uftc8inx 1115 9 and and CC cord-010092-uftc8inx 1115 10 CRF07_BC CRF07_BC NNP cord-010092-uftc8inx 1115 11 ( ( -LRB- cord-010092-uftc8inx 1115 12 61.5 61.5 CD cord-010092-uftc8inx 1115 13 % % NN cord-010092-uftc8inx 1115 14 , , , cord-010092-uftc8inx 1115 15 16/26 16/26 CD cord-010092-uftc8inx 1115 16 ) ) -RRB- cord-010092-uftc8inx 1115 17 . . . cord-010092-uftc8inx 1116 1 3 3 CD cord-010092-uftc8inx 1116 2 of of IN cord-010092-uftc8inx 1116 3 4 4 CD cord-010092-uftc8inx 1116 4 PI pi NN cord-010092-uftc8inx 1116 5 accessory accessory NN cord-010092-uftc8inx 1116 6 DRMs drm NNS cord-010092-uftc8inx 1116 7 were be VBD cord-010092-uftc8inx 1116 8 Q58E. Q58E. NNS cord-010092-uftc8inx 1117 1 The the DT cord-010092-uftc8inx 1117 2 PI PI NNP cord-010092-uftc8inx 1117 3 major major JJ cord-010092-uftc8inx 1117 4 DRMs drm NNS cord-010092-uftc8inx 1117 5 included include VBD cord-010092-uftc8inx 1117 6 M46L M46L NNP cord-010092-uftc8inx 1117 7 , , , cord-010092-uftc8inx 1117 8 M46I M46I NNP cord-010092-uftc8inx 1117 9 and and CC cord-010092-uftc8inx 1118 1 N88S. n88s. NN cord-010092-uftc8inx 1118 2 N88S n88s CC cord-010092-uftc8inx 1118 3 could could MD cord-010092-uftc8inx 1118 4 result result VB cord-010092-uftc8inx 1118 5 in in IN cord-010092-uftc8inx 1118 6 HLR HLR NNP cord-010092-uftc8inx 1118 7 to to IN cord-010092-uftc8inx 1118 8 atazanavir atazanavir NNP cord-010092-uftc8inx 1118 9 ( ( -LRB- cord-010092-uftc8inx 1118 10 ATV ATV NNP cord-010092-uftc8inx 1118 11 ) ) -RRB- cord-010092-uftc8inx 1118 12 and and CC cord-010092-uftc8inx 1118 13 NFV NFV NNP cord-010092-uftc8inx 1118 14 , , , cord-010092-uftc8inx 1118 15 LLR LLR NNP cord-010092-uftc8inx 1118 16 to to IN cord-010092-uftc8inx 1118 17 indinavir indinavir NNP cord-010092-uftc8inx 1118 18 ( ( -LRB- cord-010092-uftc8inx 1118 19 IDV IDV NNP cord-010092-uftc8inx 1118 20 ) ) -RRB- cord-010092-uftc8inx 1118 21 and and CC cord-010092-uftc8inx 1118 22 saquinavir saquinavir NNP cord-010092-uftc8inx 1118 23 ( ( -LRB- cord-010092-uftc8inx 1118 24 SQV SQV NNP cord-010092-uftc8inx 1118 25 ) ) -RRB- cord-010092-uftc8inx 1118 26 . . . cord-010092-uftc8inx 1119 1 V179D V179D NNP cord-010092-uftc8inx 1119 2 / / SYM cord-010092-uftc8inx 1119 3 E e NN cord-010092-uftc8inx 1119 4 is be VBZ cord-010092-uftc8inx 1119 5 main main JJ cord-010092-uftc8inx 1119 6 NNRTI NNRTI NNP cord-010092-uftc8inx 1119 7 DRM DRM NNP cord-010092-uftc8inx 1119 8 ( ( -LRB- cord-010092-uftc8inx 1119 9 70.0 70.0 CD cord-010092-uftc8inx 1119 10 % % NN cord-010092-uftc8inx 1119 11 , , , cord-010092-uftc8inx 1119 12 14/20 14/20 CD cord-010092-uftc8inx 1119 13 ) ) -RRB- cord-010092-uftc8inx 1119 14 . . . cord-010092-uftc8inx 1120 1 A a DT cord-010092-uftc8inx 1120 2 combination combination NN cord-010092-uftc8inx 1120 3 of of IN cord-010092-uftc8inx 1120 4 V179D v179d NN cord-010092-uftc8inx 1120 5 and and CC cord-010092-uftc8inx 1120 6 K103R k103r NN cord-010092-uftc8inx 1120 7 among among IN cord-010092-uftc8inx 1120 8 two two CD cord-010092-uftc8inx 1120 9 samples sample NNS cord-010092-uftc8inx 1120 10 acted act VBD cord-010092-uftc8inx 1120 11 synergistically synergistically RB cord-010092-uftc8inx 1120 12 to to TO cord-010092-uftc8inx 1120 13 reduce reduce VB cord-010092-uftc8inx 1120 14 efavirenz efavirenz NNP cord-010092-uftc8inx 1120 15 ( ( -LRB- cord-010092-uftc8inx 1120 16 EFV EFV NNP cord-010092-uftc8inx 1120 17 ) ) -RRB- cord-010092-uftc8inx 1120 18 and and CC cord-010092-uftc8inx 1120 19 nevirapine nevirapine NNP cord-010092-uftc8inx 1120 20 ( ( -LRB- cord-010092-uftc8inx 1120 21 NVP NVP NNP cord-010092-uftc8inx 1120 22 ) ) -RRB- cord-010092-uftc8inx 1120 23 susceptibility susceptibility NN cord-010092-uftc8inx 1120 24 . . . cord-010092-uftc8inx 1121 1 Furthermore furthermore RB cord-010092-uftc8inx 1121 2 , , , cord-010092-uftc8inx 1121 3 two two CD cord-010092-uftc8inx 1121 4 blood blood NN cord-010092-uftc8inx 1121 5 donors donor NNS cord-010092-uftc8inx 1121 6 with with IN cord-010092-uftc8inx 1121 7 K103N k103n JJ cord-010092-uftc8inx 1121 8 mutation mutation NN cord-010092-uftc8inx 1121 9 in in IN cord-010092-uftc8inx 1121 10 reverse reverse JJ cord-010092-uftc8inx 1121 11 transcriptase transcriptase NN cord-010092-uftc8inx 1121 12 gene gene NN cord-010092-uftc8inx 1121 13 had have VBD cord-010092-uftc8inx 1121 14 high high JJ cord-010092-uftc8inx 1121 15 level level NN cord-010092-uftc8inx 1121 16 - - HYPH cord-010092-uftc8inx 1121 17 resistance resistance NN cord-010092-uftc8inx 1121 18 to to IN cord-010092-uftc8inx 1121 19 EFV EFV NNP cord-010092-uftc8inx 1121 20 and and CC cord-010092-uftc8inx 1121 21 NVP NVP NNP cord-010092-uftc8inx 1121 22 . . . cord-010092-uftc8inx 1122 1 Summary Summary NNP cord-010092-uftc8inx 1122 2 / / SYM cord-010092-uftc8inx 1122 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 1122 4 : : : cord-010092-uftc8inx 1123 1 Overall overall RB cord-010092-uftc8inx 1123 2 , , , cord-010092-uftc8inx 1123 3 the the DT cord-010092-uftc8inx 1123 4 most most RBS cord-010092-uftc8inx 1123 5 prevalent prevalent JJ cord-010092-uftc8inx 1123 6 subtypes subtype NNS cord-010092-uftc8inx 1123 7 among among IN cord-010092-uftc8inx 1123 8 blood blood NN cord-010092-uftc8inx 1123 9 donors donor NNS cord-010092-uftc8inx 1123 10 in in IN cord-010092-uftc8inx 1123 11 the the DT cord-010092-uftc8inx 1123 12 study study NN cord-010092-uftc8inx 1123 13 were be VBD cord-010092-uftc8inx 1123 14 CRF07_BC CRF07_BC NNP cord-010092-uftc8inx 1123 15 ( ( -LRB- cord-010092-uftc8inx 1123 16 38.8 38.8 CD cord-010092-uftc8inx 1123 17 % % NN cord-010092-uftc8inx 1123 18 ) ) -RRB- cord-010092-uftc8inx 1123 19 , , , cord-010092-uftc8inx 1123 20 CRF01_AE CRF01_AE NNP cord-010092-uftc8inx 1123 21 ( ( -LRB- cord-010092-uftc8inx 1123 22 36.3 36.3 CD cord-010092-uftc8inx 1123 23 % % NN cord-010092-uftc8inx 1123 24 ) ) -RRB- cord-010092-uftc8inx 1123 25 . . . cord-010092-uftc8inx 1124 1 Besides besides RB cord-010092-uftc8inx 1124 2 , , , cord-010092-uftc8inx 1124 3 other other JJ cord-010092-uftc8inx 1124 4 rare rare JJ cord-010092-uftc8inx 1124 5 CRFs crf NNS cord-010092-uftc8inx 1124 6 and and CC cord-010092-uftc8inx 1124 7 several several JJ cord-010092-uftc8inx 1124 8 URF_0107 urf_0107 NN cord-010092-uftc8inx 1124 9 and and CC cord-010092-uftc8inx 1124 10 URFs urfs NN cord-010092-uftc8inx 1124 11 were be VBD cord-010092-uftc8inx 1124 12 also also RB cord-010092-uftc8inx 1124 13 found find VBN cord-010092-uftc8inx 1124 14 in in IN cord-010092-uftc8inx 1124 15 these these DT cord-010092-uftc8inx 1124 16 HIV-1 HIV-1 NNP cord-010092-uftc8inx 1124 17 isolates isolate NNS cord-010092-uftc8inx 1124 18 , , , cord-010092-uftc8inx 1124 19 which which WDT cord-010092-uftc8inx 1124 20 suggested suggest VBD cord-010092-uftc8inx 1124 21 the the DT cord-010092-uftc8inx 1124 22 epidemic epidemic NN cord-010092-uftc8inx 1124 23 of of IN cord-010092-uftc8inx 1124 24 HIV HIV NNP cord-010092-uftc8inx 1124 25 has have VBZ cord-010092-uftc8inx 1124 26 been be VBN cord-010092-uftc8inx 1124 27 shifted shift VBN cord-010092-uftc8inx 1124 28 from from IN cord-010092-uftc8inx 1124 29 high high JJ cord-010092-uftc8inx 1124 30 risk risk NN cord-010092-uftc8inx 1124 31 populations population NNS cord-010092-uftc8inx 1124 32 into into IN cord-010092-uftc8inx 1124 33 general general JJ cord-010092-uftc8inx 1124 34 populations population NNS cord-010092-uftc8inx 1124 35 , , , cord-010092-uftc8inx 1124 36 including include VBG cord-010092-uftc8inx 1124 37 blood blood NN cord-010092-uftc8inx 1124 38 donors donor NNS cord-010092-uftc8inx 1124 39 in in IN cord-010092-uftc8inx 1124 40 China China NNP cord-010092-uftc8inx 1124 41 . . . cord-010092-uftc8inx 1125 1 DRMs DRMs NNP cord-010092-uftc8inx 1125 2 were be VBD cord-010092-uftc8inx 1125 3 observed observe VBN cord-010092-uftc8inx 1125 4 in in IN cord-010092-uftc8inx 1125 5 16.3 16.3 CD cord-010092-uftc8inx 1125 6 % % NN cord-010092-uftc8inx 1125 7 donors donor NNS cord-010092-uftc8inx 1125 8 in in IN cord-010092-uftc8inx 1125 9 the the DT cord-010092-uftc8inx 1125 10 study study NN cord-010092-uftc8inx 1125 11 , , , cord-010092-uftc8inx 1125 12 which which WDT cord-010092-uftc8inx 1125 13 may may MD cord-010092-uftc8inx 1125 14 result result VB cord-010092-uftc8inx 1125 15 in in IN cord-010092-uftc8inx 1125 16 resistance resistance NN cord-010092-uftc8inx 1125 17 to to IN cord-010092-uftc8inx 1125 18 PIs pi NNS cord-010092-uftc8inx 1125 19 and and CC cord-010092-uftc8inx 1125 20 NNRTIs nnrti NNS cord-010092-uftc8inx 1125 21 , , , cord-010092-uftc8inx 1125 22 especially especially RB cord-010092-uftc8inx 1125 23 the the DT cord-010092-uftc8inx 1125 24 HIV-1 HIV-1 NNP cord-010092-uftc8inx 1125 25 variants variant NNS cord-010092-uftc8inx 1125 26 with with IN cord-010092-uftc8inx 1125 27 N88S n88s JJ cord-010092-uftc8inx 1125 28 mutation mutation NN cord-010092-uftc8inx 1125 29 in in IN cord-010092-uftc8inx 1125 30 PR PR NNP cord-010092-uftc8inx 1125 31 gene gene NN cord-010092-uftc8inx 1125 32 and and CC cord-010092-uftc8inx 1125 33 K103N k103n JJ cord-010092-uftc8inx 1125 34 mutation mutation NN cord-010092-uftc8inx 1125 35 in in IN cord-010092-uftc8inx 1125 36 RT RT NNP cord-010092-uftc8inx 1125 37 gene gene NN cord-010092-uftc8inx 1125 38 . . . cord-010092-uftc8inx 1126 1 In in IN cord-010092-uftc8inx 1126 2 summary summary NN cord-010092-uftc8inx 1126 3 , , , cord-010092-uftc8inx 1126 4 our -PRON- PRP$ cord-010092-uftc8inx 1126 5 findings finding NNS cord-010092-uftc8inx 1126 6 indicate indicate VBP cord-010092-uftc8inx 1126 7 that that IN cord-010092-uftc8inx 1126 8 increasing increase VBG cord-010092-uftc8inx 1126 9 diversity diversity NN cord-010092-uftc8inx 1126 10 of of IN cord-010092-uftc8inx 1126 11 HIV-1 HIV-1 NNP cord-010092-uftc8inx 1126 12 in in IN cord-010092-uftc8inx 1126 13 blood blood NN cord-010092-uftc8inx 1126 14 donors donor NNS cord-010092-uftc8inx 1126 15 and and CC cord-010092-uftc8inx 1126 16 remind remind VB cord-010092-uftc8inx 1126 17 us -PRON- PRP cord-010092-uftc8inx 1126 18 the the DT cord-010092-uftc8inx 1126 19 necessity necessity NN cord-010092-uftc8inx 1126 20 of of IN cord-010092-uftc8inx 1126 21 timely timely JJ cord-010092-uftc8inx 1126 22 genotypic genotypic JJ cord-010092-uftc8inx 1126 23 drug drug NN cord-010092-uftc8inx 1126 24 resistance resistance NN cord-010092-uftc8inx 1126 25 monitoring monitoring NN cord-010092-uftc8inx 1126 26 and and CC cord-010092-uftc8inx 1126 27 molecular molecular JJ cord-010092-uftc8inx 1126 28 epidemiology epidemiology NN cord-010092-uftc8inx 1126 29 surveillance surveillance NN cord-010092-uftc8inx 1126 30 of of IN cord-010092-uftc8inx 1126 31 HIV-1 HIV-1 NNP cord-010092-uftc8inx 1126 32 among among IN cord-010092-uftc8inx 1126 33 blood blood NN cord-010092-uftc8inx 1126 34 donors donor NNS cord-010092-uftc8inx 1126 35 . . . cord-010092-uftc8inx 1127 1 Background background NN cord-010092-uftc8inx 1127 2 : : : cord-010092-uftc8inx 1128 1 Labeling labeling NN cord-010092-uftc8inx 1128 2 of of IN cord-010092-uftc8inx 1128 3 platelets platelet NNS cord-010092-uftc8inx 1128 4 is be VBZ cord-010092-uftc8inx 1128 5 required require VBN cord-010092-uftc8inx 1128 6 to to TO cord-010092-uftc8inx 1128 7 measure measure VB cord-010092-uftc8inx 1128 8 the the DT cord-010092-uftc8inx 1128 9 recovery recovery NN cord-010092-uftc8inx 1128 10 and and CC cord-010092-uftc8inx 1128 11 survival survival NN cord-010092-uftc8inx 1128 12 of of IN cord-010092-uftc8inx 1128 13 transfused transfused JJ cord-010092-uftc8inx 1128 14 platelets platelet NNS cord-010092-uftc8inx 1128 15 in in IN cord-010092-uftc8inx 1128 16 vivo vivo NN cord-010092-uftc8inx 1128 17 . . . cord-010092-uftc8inx 1129 1 Currently currently RB cord-010092-uftc8inx 1129 2 a a DT cord-010092-uftc8inx 1129 3 radioactive radioactive JJ cord-010092-uftc8inx 1129 4 method method NN cord-010092-uftc8inx 1129 5 is be VBZ cord-010092-uftc8inx 1129 6 used use VBN cord-010092-uftc8inx 1129 7 to to TO cord-010092-uftc8inx 1129 8 label label VB cord-010092-uftc8inx 1129 9 platelets platelet NNS cord-010092-uftc8inx 1129 10 . . . cord-010092-uftc8inx 1130 1 However however RB cord-010092-uftc8inx 1130 2 , , , cord-010092-uftc8inx 1130 3 its -PRON- PRP$ cord-010092-uftc8inx 1130 4 ' ' `` cord-010092-uftc8inx 1130 5 application application NN cord-010092-uftc8inx 1130 6 is be VBZ cord-010092-uftc8inx 1130 7 limited limit VBN cord-010092-uftc8inx 1130 8 , , , cord-010092-uftc8inx 1130 9 due due IN cord-010092-uftc8inx 1130 10 to to IN cord-010092-uftc8inx 1130 11 safety safety NN cord-010092-uftc8inx 1130 12 issues issue NNS cord-010092-uftc8inx 1130 13 and and CC cord-010092-uftc8inx 1130 14 the the DT cord-010092-uftc8inx 1130 15 inability inability NN cord-010092-uftc8inx 1130 16 to to TO cord-010092-uftc8inx 1130 17 isolate isolate VB cord-010092-uftc8inx 1130 18 transfused transfused JJ cord-010092-uftc8inx 1130 19 platelets platelet NNS cord-010092-uftc8inx 1130 20 out out IN cord-010092-uftc8inx 1130 21 of of IN cord-010092-uftc8inx 1130 22 the the DT cord-010092-uftc8inx 1130 23 circulation circulation NN cord-010092-uftc8inx 1130 24 . . . cord-010092-uftc8inx 1131 1 Biotin biotin NN cord-010092-uftc8inx 1131 2 - - HYPH cord-010092-uftc8inx 1131 3 labeling labeling NN cord-010092-uftc8inx 1131 4 of of IN cord-010092-uftc8inx 1131 5 platelets platelet NNS cord-010092-uftc8inx 1131 6 is be VBZ cord-010092-uftc8inx 1131 7 an an DT cord-010092-uftc8inx 1131 8 attractive attractive JJ cord-010092-uftc8inx 1131 9 non non JJ cord-010092-uftc8inx 1131 10 - - JJ cord-010092-uftc8inx 1131 11 radioactive radioactive JJ cord-010092-uftc8inx 1131 12 option option NN cord-010092-uftc8inx 1131 13 , , , cord-010092-uftc8inx 1131 14 however however RB cord-010092-uftc8inx 1131 15 , , , cord-010092-uftc8inx 1131 16 no no DT cord-010092-uftc8inx 1131 17 validated validate VBN cord-010092-uftc8inx 1131 18 protocol protocol NN cord-010092-uftc8inx 1131 19 to to IN cord-010092-uftc8inx 1131 20 biotinylate biotinylate NN cord-010092-uftc8inx 1131 21 platelets platelet NNS cord-010092-uftc8inx 1131 22 is be VBZ cord-010092-uftc8inx 1131 23 currently currently RB cord-010092-uftc8inx 1131 24 available available JJ cord-010092-uftc8inx 1131 25 for for IN cord-010092-uftc8inx 1131 26 clinical clinical JJ cord-010092-uftc8inx 1131 27 purposes purpose NNS cord-010092-uftc8inx 1131 28 . . . cord-010092-uftc8inx 1132 1 Aims aim VBZ cord-010092-uftc8inx 1132 2 : : : cord-010092-uftc8inx 1133 1 The the DT cord-010092-uftc8inx 1133 2 aim aim NN cord-010092-uftc8inx 1133 3 of of IN cord-010092-uftc8inx 1133 4 this this DT cord-010092-uftc8inx 1133 5 study study NN cord-010092-uftc8inx 1133 6 is be VBZ cord-010092-uftc8inx 1133 7 to to TO cord-010092-uftc8inx 1133 8 develop develop VB cord-010092-uftc8inx 1133 9 a a DT cord-010092-uftc8inx 1133 10 simple simple JJ cord-010092-uftc8inx 1133 11 , , , cord-010092-uftc8inx 1133 12 standardized standardized JJ cord-010092-uftc8inx 1133 13 , , , cord-010092-uftc8inx 1133 14 reproducible reproducible JJ cord-010092-uftc8inx 1133 15 method method NN cord-010092-uftc8inx 1133 16 to to IN cord-010092-uftc8inx 1133 17 label label VB cord-010092-uftc8inx 1133 18 platelets platelet NNS cord-010092-uftc8inx 1133 19 with with IN cord-010092-uftc8inx 1133 20 biotin biotin NN cord-010092-uftc8inx 1133 21 as as IN cord-010092-uftc8inx 1133 22 a a DT cord-010092-uftc8inx 1133 23 non non JJ cord-010092-uftc8inx 1133 24 - - JJ cord-010092-uftc8inx 1133 25 radioactive radioactive JJ cord-010092-uftc8inx 1133 26 alternative alternative NN cord-010092-uftc8inx 1133 27 to to IN cord-010092-uftc8inx 1133 28 trace trace NN cord-010092-uftc8inx 1133 29 transfused transfused JJ cord-010092-uftc8inx 1133 30 platelets platelet NNS cord-010092-uftc8inx 1133 31 in in IN cord-010092-uftc8inx 1133 32 vivo vivo NN cord-010092-uftc8inx 1133 33 . . . cord-010092-uftc8inx 1134 1 Methods method NNS cord-010092-uftc8inx 1134 2 : : : cord-010092-uftc8inx 1135 1 Six six CD cord-010092-uftc8inx 1135 2 pooled pool VBN cord-010092-uftc8inx 1135 3 buffy buffy NNP cord-010092-uftc8inx 1135 4 coats coat NNS cord-010092-uftc8inx 1135 5 derived derive VBD cord-010092-uftc8inx 1135 6 platelet platelet NN cord-010092-uftc8inx 1135 7 concentrates concentrate VBZ cord-010092-uftc8inx 1135 8 ( ( -LRB- cord-010092-uftc8inx 1135 9 PCs pc NNS cord-010092-uftc8inx 1135 10 ) ) -RRB- cord-010092-uftc8inx 1135 11 stored store VBN cord-010092-uftc8inx 1135 12 in in IN cord-010092-uftc8inx 1135 13 100 100 CD cord-010092-uftc8inx 1135 14 % % NN cord-010092-uftc8inx 1135 15 plasma plasma NN cord-010092-uftc8inx 1135 16 were be VBD cord-010092-uftc8inx 1135 17 biotinylated biotinylate VBN cord-010092-uftc8inx 1135 18 at at IN cord-010092-uftc8inx 1135 19 day day NN cord-010092-uftc8inx 1135 20 1 1 CD cord-010092-uftc8inx 1135 21 and and CC cord-010092-uftc8inx 1135 22 day day NN cord-010092-uftc8inx 1135 23 7 7 CD cord-010092-uftc8inx 1135 24 of of IN cord-010092-uftc8inx 1135 25 storage storage NN cord-010092-uftc8inx 1135 26 . . . cord-010092-uftc8inx 1136 1 To to TO cord-010092-uftc8inx 1136 2 distinguish distinguish VB cord-010092-uftc8inx 1136 3 the the DT cord-010092-uftc8inx 1136 4 effect effect NN cord-010092-uftc8inx 1136 5 of of IN cord-010092-uftc8inx 1136 6 the the DT cord-010092-uftc8inx 1136 7 processing processing NN cord-010092-uftc8inx 1136 8 steps step NNS cord-010092-uftc8inx 1136 9 from from IN cord-010092-uftc8inx 1136 10 the the DT cord-010092-uftc8inx 1136 11 effects effect NNS cord-010092-uftc8inx 1136 12 of of IN cord-010092-uftc8inx 1136 13 biotin biotin NN cord-010092-uftc8inx 1136 14 incubation incubation NN cord-010092-uftc8inx 1136 15 , , , cord-010092-uftc8inx 1136 16 ' ' '' cord-010092-uftc8inx 1136 17 sham sham NN cord-010092-uftc8inx 1136 18 ' ' '' cord-010092-uftc8inx 1136 19 samples sample NNS cord-010092-uftc8inx 1136 20 were be VBD cord-010092-uftc8inx 1136 21 processed process VBN cord-010092-uftc8inx 1136 22 . . . cord-010092-uftc8inx 1137 1 For for IN cord-010092-uftc8inx 1137 2 the the DT cord-010092-uftc8inx 1137 3 biotinylation biotinylation NN cord-010092-uftc8inx 1137 4 procedure procedure NN cord-010092-uftc8inx 1137 5 , , , cord-010092-uftc8inx 1137 6 50 50 CD cord-010092-uftc8inx 1137 7 ml ml NNS cord-010092-uftc8inx 1137 8 of of IN cord-010092-uftc8inx 1137 9 PCs pc NNS cord-010092-uftc8inx 1137 10 was be VBD cord-010092-uftc8inx 1137 11 washed wash VBN cord-010092-uftc8inx 1137 12 twice twice RB cord-010092-uftc8inx 1137 13 and and CC cord-010092-uftc8inx 1137 14 incubated incubate VBN cord-010092-uftc8inx 1137 15 with with IN cord-010092-uftc8inx 1137 16 5 5 CD cord-010092-uftc8inx 1137 17 mg mg NNP cord-010092-uftc8inx 1137 18 / / SYM cord-010092-uftc8inx 1137 19 L L NNP cord-010092-uftc8inx 1137 20 biotin biotin NNP cord-010092-uftc8inx 1137 21 , , , cord-010092-uftc8inx 1137 22 dissolved dissolve VBN cord-010092-uftc8inx 1137 23 in in IN cord-010092-uftc8inx 1137 24 phosphate phosphate NN cord-010092-uftc8inx 1137 25 buffered buffer VBN cord-010092-uftc8inx 1137 26 saline saline NN cord-010092-uftc8inx 1137 27 - - HYPH cord-010092-uftc8inx 1137 28 PAS pas NN cord-010092-uftc8inx 1137 29 - - HYPH cord-010092-uftc8inx 1137 30 E e NN cord-010092-uftc8inx 1137 31 ( ( -LRB- cord-010092-uftc8inx 1137 32 1:9 1:9 CD cord-010092-uftc8inx 1137 33 ) ) -RRB- cord-010092-uftc8inx 1137 34 , , , cord-010092-uftc8inx 1137 35 for for IN cord-010092-uftc8inx 1137 36 30 30 CD cord-010092-uftc8inx 1137 37 min min NN cord-010092-uftc8inx 1137 38 . . . cord-010092-uftc8inx 1138 1 Stability stability NN cord-010092-uftc8inx 1138 2 of of IN cord-010092-uftc8inx 1138 3 the the DT cord-010092-uftc8inx 1138 4 biotin biotin NN cord-010092-uftc8inx 1138 5 labeled label VBN cord-010092-uftc8inx 1138 6 platelets platelet NNS cord-010092-uftc8inx 1138 7 after after IN cord-010092-uftc8inx 1138 8 irradiation irradiation NN cord-010092-uftc8inx 1138 9 was be VBD cord-010092-uftc8inx 1138 10 tested test VBN cord-010092-uftc8inx 1138 11 . . . cord-010092-uftc8inx 1139 1 Annexin Annexin NNP cord-010092-uftc8inx 1139 2 V V NNP cord-010092-uftc8inx 1139 3 and and CC cord-010092-uftc8inx 1139 4 CD62P cd62p NN cord-010092-uftc8inx 1139 5 expression expression NN cord-010092-uftc8inx 1139 6 were be VBD cord-010092-uftc8inx 1139 7 assessed assess VBN cord-010092-uftc8inx 1139 8 as as IN cord-010092-uftc8inx 1139 9 measures measure NNS cord-010092-uftc8inx 1139 10 of of IN cord-010092-uftc8inx 1139 11 platelet platelet NN cord-010092-uftc8inx 1139 12 activation activation NN cord-010092-uftc8inx 1139 13 . . . cord-010092-uftc8inx 1140 1 Applicability applicability NN cord-010092-uftc8inx 1140 2 of of IN cord-010092-uftc8inx 1140 3 this this DT cord-010092-uftc8inx 1140 4 method method NN cord-010092-uftc8inx 1140 5 to to IN cord-010092-uftc8inx 1140 6 other other JJ cord-010092-uftc8inx 1140 7 platelet platelet NN cord-010092-uftc8inx 1140 8 products product NNS cord-010092-uftc8inx 1140 9 was be VBD cord-010092-uftc8inx 1140 10 assessed assess VBN cord-010092-uftc8inx 1140 11 in in IN cord-010092-uftc8inx 1140 12 three three CD cord-010092-uftc8inx 1140 13 pooled pool VBN cord-010092-uftc8inx 1140 14 PCs pc NNS cord-010092-uftc8inx 1140 15 stored store VBN cord-010092-uftc8inx 1140 16 in in IN cord-010092-uftc8inx 1140 17 65 65 CD cord-010092-uftc8inx 1140 18 % % NN cord-010092-uftc8inx 1140 19 PAS pas NN cord-010092-uftc8inx 1140 20 - - HYPH cord-010092-uftc8inx 1140 21 E e NN cord-010092-uftc8inx 1140 22 and and CC cord-010092-uftc8inx 1140 23 three three CD cord-010092-uftc8inx 1140 24 single single JJ cord-010092-uftc8inx 1140 25 donor donor NN cord-010092-uftc8inx 1140 26 apheresis apheresis NN cord-010092-uftc8inx 1140 27 PCs pc NNS cord-010092-uftc8inx 1140 28 . . . cord-010092-uftc8inx 1141 1 Results result NNS cord-010092-uftc8inx 1141 2 : : : cord-010092-uftc8inx 1142 1 The the DT cord-010092-uftc8inx 1142 2 method method NN cord-010092-uftc8inx 1142 3 was be VBD cord-010092-uftc8inx 1142 4 reproducible reproducible JJ cord-010092-uftc8inx 1142 5 performed perform VBN cord-010092-uftc8inx 1142 6 in in IN cord-010092-uftc8inx 1142 7 a a DT cord-010092-uftc8inx 1142 8 closed closed JJ cord-010092-uftc8inx 1142 9 system system NN cord-010092-uftc8inx 1142 10 . . . cord-010092-uftc8inx 1143 1 After after IN cord-010092-uftc8inx 1143 2 biotinylation biotinylation NN cord-010092-uftc8inx 1143 3 , , , cord-010092-uftc8inx 1143 4 98.4 98.4 CD cord-010092-uftc8inx 1143 5 % % NN cord-010092-uftc8inx 1143 6 AE AE NNP cord-010092-uftc8inx 1143 7 0.9 0.9 CD cord-010092-uftc8inx 1143 8 % % NN cord-010092-uftc8inx 1143 9 of of IN cord-010092-uftc8inx 1143 10 platelets platelet NNS cord-010092-uftc8inx 1143 11 were be VBD cord-010092-uftc8inx 1143 12 labeled label VBN cord-010092-uftc8inx 1143 13 . . . cord-010092-uftc8inx 1144 1 Platelet platelet NN cord-010092-uftc8inx 1144 2 counts count NNS cord-010092-uftc8inx 1144 3 , , , cord-010092-uftc8inx 1144 4 pH ph NN cord-010092-uftc8inx 1144 5 and and CC cord-010092-uftc8inx 1144 6 ' ' `` cord-010092-uftc8inx 1144 7 swirling swirl VBG cord-010092-uftc8inx 1144 8 ' ' '' cord-010092-uftc8inx 1144 9 were be VBD cord-010092-uftc8inx 1144 10 within within IN cord-010092-uftc8inx 1144 11 the the DT cord-010092-uftc8inx 1144 12 range range NN cord-010092-uftc8inx 1144 13 accepted accept VBN cord-010092-uftc8inx 1144 14 by by IN cord-010092-uftc8inx 1144 15 the the DT cord-010092-uftc8inx 1144 16 Dutch dutch JJ cord-010092-uftc8inx 1144 17 blood blood NN cord-010092-uftc8inx 1144 18 bank bank NN cord-010092-uftc8inx 1144 19 for for IN cord-010092-uftc8inx 1144 20 standard standard JJ cord-010092-uftc8inx 1144 21 platelet platelet NN cord-010092-uftc8inx 1144 22 products product NNS cord-010092-uftc8inx 1144 23 . . . cord-010092-uftc8inx 1145 1 The the DT cord-010092-uftc8inx 1145 2 number number NN cord-010092-uftc8inx 1145 3 of of IN cord-010092-uftc8inx 1145 4 annexin annexin JJ cord-010092-uftc8inx 1145 5 V V NNP cord-010092-uftc8inx 1145 6 positive positive JJ cord-010092-uftc8inx 1145 7 cells cell NNS cord-010092-uftc8inx 1145 8 was be VBD cord-010092-uftc8inx 1145 9 not not RB cord-010092-uftc8inx 1145 10 significantly significantly RB cord-010092-uftc8inx 1145 11 altered alter VBN cord-010092-uftc8inx 1145 12 by by IN cord-010092-uftc8inx 1145 13 the the DT cord-010092-uftc8inx 1145 14 biotinylation biotinylation NN cord-010092-uftc8inx 1145 15 procedure procedure NN cord-010092-uftc8inx 1145 16 in in IN cord-010092-uftc8inx 1145 17 both both CC cord-010092-uftc8inx 1145 18 fresh fresh JJ cord-010092-uftc8inx 1145 19 and and CC cord-010092-uftc8inx 1145 20 stored stored JJ cord-010092-uftc8inx 1145 21 platelets platelet NNS cord-010092-uftc8inx 1145 22 . . . cord-010092-uftc8inx 1146 1 In in IN cord-010092-uftc8inx 1146 2 contrast contrast NN cord-010092-uftc8inx 1146 3 , , , cord-010092-uftc8inx 1146 4 CD62P CD62P NNP cord-010092-uftc8inx 1146 5 expression expression NN cord-010092-uftc8inx 1146 6 was be VBD cord-010092-uftc8inx 1146 7 increased increase VBN cord-010092-uftc8inx 1146 8 in in IN cord-010092-uftc8inx 1146 9 biotinylated biotinylated JJ cord-010092-uftc8inx 1146 10 platelets platelet NNS cord-010092-uftc8inx 1146 11 48.4 48.4 CD cord-010092-uftc8inx 1146 12 % % NN cord-010092-uftc8inx 1146 13 IQR(41.7 iqr(41.7 CD cord-010092-uftc8inx 1146 14 - - HYPH cord-010092-uftc8inx 1146 15 56.2 56.2 CD cord-010092-uftc8inx 1146 16 % % NN cord-010092-uftc8inx 1146 17 ) ) -RRB- cord-010092-uftc8inx 1146 18 compared compare VBN cord-010092-uftc8inx 1146 19 to to IN cord-010092-uftc8inx 1146 20 the the DT cord-010092-uftc8inx 1146 21 control control NN cord-010092-uftc8inx 1146 22 samples sample NNS cord-010092-uftc8inx 1146 23 12.3 12.3 CD cord-010092-uftc8inx 1146 24 % % NN cord-010092-uftc8inx 1146 25 IQR(9.5 iqr(9.5 NN cord-010092-uftc8inx 1146 26 - - HYPH cord-010092-uftc8inx 1146 27 12.7 12.7 CD cord-010092-uftc8inx 1146 28 % % NN cord-010092-uftc8inx 1146 29 ) ) -RRB- cord-010092-uftc8inx 1146 30 on on IN cord-010092-uftc8inx 1146 31 day day NN cord-010092-uftc8inx 1146 32 1 1 CD cord-010092-uftc8inx 1146 33 of of IN cord-010092-uftc8inx 1146 34 storage storage NN cord-010092-uftc8inx 1146 35 . . . cord-010092-uftc8inx 1147 1 However however RB cord-010092-uftc8inx 1147 2 , , , cord-010092-uftc8inx 1147 3 biotinylated biotinylated JJ cord-010092-uftc8inx 1147 4 platelets platelet NNS cord-010092-uftc8inx 1147 5 were be VBD cord-010092-uftc8inx 1147 6 not not RB cord-010092-uftc8inx 1147 7 more more RBR cord-010092-uftc8inx 1147 8 activated activate VBN cord-010092-uftc8inx 1147 9 compared compare VBN cord-010092-uftc8inx 1147 10 to to IN cord-010092-uftc8inx 1147 11 sham sham NN cord-010092-uftc8inx 1147 12 samples sample NNS cord-010092-uftc8inx 1147 13 50 50 CD cord-010092-uftc8inx 1147 14 % % NN cord-010092-uftc8inx 1147 15 IQR(41.7 iqr(41.7 CD cord-010092-uftc8inx 1147 16 - - HYPH cord-010092-uftc8inx 1147 17 56.2 56.2 CD cord-010092-uftc8inx 1147 18 % % NN cord-010092-uftc8inx 1147 19 ) ) -RRB- cord-010092-uftc8inx 1147 20 . . . cord-010092-uftc8inx 1148 1 Thus thus RB cord-010092-uftc8inx 1148 2 only only RB cord-010092-uftc8inx 1148 3 the the DT cord-010092-uftc8inx 1148 4 procedural procedural JJ cord-010092-uftc8inx 1148 5 steps step NNS cord-010092-uftc8inx 1148 6 led lead VBD cord-010092-uftc8inx 1148 7 to to IN cord-010092-uftc8inx 1148 8 increased increase VBN cord-010092-uftc8inx 1148 9 CD62P cd62p NN cord-010092-uftc8inx 1148 10 expression expression NN cord-010092-uftc8inx 1148 11 and and CC cord-010092-uftc8inx 1148 12 not not RB cord-010092-uftc8inx 1148 13 the the DT cord-010092-uftc8inx 1148 14 biotin biotin NN cord-010092-uftc8inx 1148 15 label label NN cord-010092-uftc8inx 1148 16 itself -PRON- PRP cord-010092-uftc8inx 1148 17 . . . cord-010092-uftc8inx 1149 1 All all DT cord-010092-uftc8inx 1149 2 samples sample NNS cord-010092-uftc8inx 1149 3 showed show VBD cord-010092-uftc8inx 1149 4 maximal maximal JJ cord-010092-uftc8inx 1149 5 response response NN cord-010092-uftc8inx 1149 6 to to IN cord-010092-uftc8inx 1149 7 thrombin thrombin JJ cord-010092-uftc8inx 1149 8 receptor receptor NN cord-010092-uftc8inx 1149 9 - - HYPH cord-010092-uftc8inx 1149 10 activating activate VBG cord-010092-uftc8inx 1149 11 peptide peptide NN cord-010092-uftc8inx 1149 12 . . . cord-010092-uftc8inx 1150 1 For for IN cord-010092-uftc8inx 1150 2 platelets platelet NNS cord-010092-uftc8inx 1150 3 labeled label VBN cord-010092-uftc8inx 1150 4 at at IN cord-010092-uftc8inx 1150 5 day day NN cord-010092-uftc8inx 1150 6 7 7 CD cord-010092-uftc8inx 1150 7 , , , cord-010092-uftc8inx 1150 8 a a DT cord-010092-uftc8inx 1150 9 similar similar JJ cord-010092-uftc8inx 1150 10 pattern pattern NN cord-010092-uftc8inx 1150 11 was be VBD cord-010092-uftc8inx 1150 12 observed observe VBN cord-010092-uftc8inx 1150 13 . . . cord-010092-uftc8inx 1151 1 Irradiation irradiation NN cord-010092-uftc8inx 1151 2 of of IN cord-010092-uftc8inx 1151 3 biotin biotin NN cord-010092-uftc8inx 1151 4 labeled label VBN cord-010092-uftc8inx 1151 5 platelets platelet NNS cord-010092-uftc8inx 1151 6 did do VBD cord-010092-uftc8inx 1151 7 not not RB cord-010092-uftc8inx 1151 8 alter alter VB cord-010092-uftc8inx 1151 9 the the DT cord-010092-uftc8inx 1151 10 stability stability NN cord-010092-uftc8inx 1151 11 of of IN cord-010092-uftc8inx 1151 12 the the DT cord-010092-uftc8inx 1151 13 biotin biotin NN cord-010092-uftc8inx 1151 14 label label NN cord-010092-uftc8inx 1151 15 nor nor CC cord-010092-uftc8inx 1151 16 cell cell NN cord-010092-uftc8inx 1151 17 quality quality NN cord-010092-uftc8inx 1151 18 . . . cord-010092-uftc8inx 1152 1 Furthermore furthermore RB cord-010092-uftc8inx 1152 2 this this DT cord-010092-uftc8inx 1152 3 method method NN cord-010092-uftc8inx 1152 4 is be VBZ cord-010092-uftc8inx 1152 5 also also RB cord-010092-uftc8inx 1152 6 applicable applicable JJ cord-010092-uftc8inx 1152 7 to to IN cord-010092-uftc8inx 1152 8 pooled pool VBN cord-010092-uftc8inx 1152 9 PCs pc NNS cord-010092-uftc8inx 1152 10 stored store VBN cord-010092-uftc8inx 1152 11 in in IN cord-010092-uftc8inx 1152 12 PAS pas NN cord-010092-uftc8inx 1152 13 - - HYPH cord-010092-uftc8inx 1152 14 E e NN cord-010092-uftc8inx 1152 15 and and CC cord-010092-uftc8inx 1152 16 apheresis apheresis NN cord-010092-uftc8inx 1152 17 PCs pc NNS cord-010092-uftc8inx 1152 18 , , , cord-010092-uftc8inx 1152 19 with with IN cord-010092-uftc8inx 1152 20 similar similar JJ cord-010092-uftc8inx 1152 21 patterns pattern NNS cord-010092-uftc8inx 1152 22 in in IN cord-010092-uftc8inx 1152 23 annexin annexin NNP cord-010092-uftc8inx 1152 24 V V NNP cord-010092-uftc8inx 1152 25 and and CC cord-010092-uftc8inx 1152 26 CD62P CD62P NNP cord-010092-uftc8inx 1152 27 expression expression NN cord-010092-uftc8inx 1152 28 . . . cord-010092-uftc8inx 1153 1 Summary Summary NNP cord-010092-uftc8inx 1153 2 / / SYM cord-010092-uftc8inx 1153 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 1154 1 : : : cord-010092-uftc8inx 1154 2 We -PRON- PRP cord-010092-uftc8inx 1154 3 developed develop VBD cord-010092-uftc8inx 1154 4 a a DT cord-010092-uftc8inx 1154 5 standardized standardized JJ cord-010092-uftc8inx 1154 6 and and CC cord-010092-uftc8inx 1154 7 reproducible reproducible JJ cord-010092-uftc8inx 1154 8 protocol protocol NN cord-010092-uftc8inx 1154 9 according accord VBG cord-010092-uftc8inx 1154 10 to to IN cord-010092-uftc8inx 1154 11 Good Good NNP cord-010092-uftc8inx 1154 12 Practice Practice NNP cord-010092-uftc8inx 1154 13 Guidelines Guidelines NNPS cord-010092-uftc8inx 1154 14 ( ( -LRB- cord-010092-uftc8inx 1154 15 GPG GPG NNP cord-010092-uftc8inx 1154 16 ) ) -RRB- cord-010092-uftc8inx 1154 17 standards standard NNS cord-010092-uftc8inx 1154 18 , , , cord-010092-uftc8inx 1154 19 for for IN cord-010092-uftc8inx 1154 20 biotin biotin NN cord-010092-uftc8inx 1154 21 - - HYPH cord-010092-uftc8inx 1154 22 labeling labeling NN cord-010092-uftc8inx 1154 23 of of IN cord-010092-uftc8inx 1154 24 platelets platelet NNS cord-010092-uftc8inx 1154 25 for for IN cord-010092-uftc8inx 1154 26 clinical clinical JJ cord-010092-uftc8inx 1154 27 purposes purpose NNS cord-010092-uftc8inx 1154 28 . . . cord-010092-uftc8inx 1155 1 The the DT cord-010092-uftc8inx 1155 2 procedural procedural JJ cord-010092-uftc8inx 1155 3 steps step NNS cord-010092-uftc8inx 1155 4 , , , cord-010092-uftc8inx 1155 5 which which WDT cord-010092-uftc8inx 1155 6 are be VBP cord-010092-uftc8inx 1155 7 similar similar JJ cord-010092-uftc8inx 1155 8 to to IN cord-010092-uftc8inx 1155 9 the the DT cord-010092-uftc8inx 1155 10 steps step NNS cord-010092-uftc8inx 1155 11 used use VBN cord-010092-uftc8inx 1155 12 for for IN cord-010092-uftc8inx 1155 13 production production NN cord-010092-uftc8inx 1155 14 of of IN cord-010092-uftc8inx 1155 15 hyperconcentrated hyperconcentrate VBN cord-010092-uftc8inx 1155 16 platelet platelet NN cord-010092-uftc8inx 1155 17 products product NNS cord-010092-uftc8inx 1155 18 , , , cord-010092-uftc8inx 1155 19 led lead VBD cord-010092-uftc8inx 1155 20 to to IN cord-010092-uftc8inx 1155 21 an an DT cord-010092-uftc8inx 1155 22 increased increase VBN cord-010092-uftc8inx 1155 23 CD62P cd62p NN cord-010092-uftc8inx 1155 24 expression expression NN cord-010092-uftc8inx 1155 25 , , , cord-010092-uftc8inx 1155 26 but but CC cord-010092-uftc8inx 1155 27 did do VBD cord-010092-uftc8inx 1155 28 not not RB cord-010092-uftc8inx 1155 29 alter alter VB cord-010092-uftc8inx 1155 30 the the DT cord-010092-uftc8inx 1155 31 annexin annexin NN cord-010092-uftc8inx 1155 32 V v CD cord-010092-uftc8inx 1155 33 expression expression NN cord-010092-uftc8inx 1155 34 . . . cord-010092-uftc8inx 1156 1 This this DT cord-010092-uftc8inx 1156 2 method method NN cord-010092-uftc8inx 1156 3 can can MD cord-010092-uftc8inx 1156 4 be be VB cord-010092-uftc8inx 1156 5 applied apply VBN cord-010092-uftc8inx 1156 6 as as IN cord-010092-uftc8inx 1156 7 non non JJ cord-010092-uftc8inx 1156 8 - - JJ cord-010092-uftc8inx 1156 9 radioactive radioactive JJ cord-010092-uftc8inx 1156 10 alternative alternative NN cord-010092-uftc8inx 1156 11 to to IN cord-010092-uftc8inx 1156 12 trace trace VB cord-010092-uftc8inx 1156 13 and and CC cord-010092-uftc8inx 1156 14 recover recover VB cord-010092-uftc8inx 1156 15 transfused transfused JJ cord-010092-uftc8inx 1156 16 platelets platelet NNS cord-010092-uftc8inx 1156 17 in in IN cord-010092-uftc8inx 1156 18 vivo vivo NN cord-010092-uftc8inx 1156 19 . . . cord-010092-uftc8inx 1157 1 blocking block VBG cord-010092-uftc8inx 1157 2 activity activity NN cord-010092-uftc8inx 1157 3 over over IN cord-010092-uftc8inx 1157 4 the the DT cord-010092-uftc8inx 1157 5 prototypic prototypic NNP cord-010092-uftc8inx 1158 1 cHS4 chs4 IN cord-010092-uftc8inx 1158 2 insulator insulator NN cord-010092-uftc8inx 1158 3 in in IN cord-010092-uftc8inx 1158 4 cell cell NN cord-010092-uftc8inx 1158 5 lines line NNS cord-010092-uftc8inx 1158 6 and and CC cord-010092-uftc8inx 1158 7 substantially substantially RB cord-010092-uftc8inx 1158 8 reducing reduce VBG cord-010092-uftc8inx 1158 9 genotoxicity genotoxicity NN cord-010092-uftc8inx 1158 10 in in IN cord-010092-uftc8inx 1158 11 a a DT cord-010092-uftc8inx 1158 12 c c NN cord-010092-uftc8inx 1158 13 - - HYPH cord-010092-uftc8inx 1158 14 retroviral retroviral NN cord-010092-uftc8inx 1158 15 vector vector NN cord-010092-uftc8inx 1158 16 - - HYPH cord-010092-uftc8inx 1158 17 mediated mediate VBN cord-010092-uftc8inx 1158 18 carcinogenesis carcinogenesis NN cord-010092-uftc8inx 1158 19 mouse mouse NN cord-010092-uftc8inx 1158 20 model model NN cord-010092-uftc8inx 1158 21 . . . cord-010092-uftc8inx 1159 1 In in IN cord-010092-uftc8inx 1159 2 contrast contrast NN cord-010092-uftc8inx 1159 3 to to IN cord-010092-uftc8inx 1159 4 cHS4 cHS4 NNP cord-010092-uftc8inx 1159 5 , , , cord-010092-uftc8inx 1159 6 these these DT cord-010092-uftc8inx 1159 7 insulators insulator NNS cord-010092-uftc8inx 1159 8 are be VBP cord-010092-uftc8inx 1159 9 small small JJ cord-010092-uftc8inx 1159 10 - - HYPH cord-010092-uftc8inx 1159 11 sized sized JJ cord-010092-uftc8inx 1159 12 ( ( -LRB- cord-010092-uftc8inx 1159 13 119 119 CD cord-010092-uftc8inx 1159 14 - - SYM cord-010092-uftc8inx 1159 15 284 284 CD cord-010092-uftc8inx 1159 16 bp bp NNP cord-010092-uftc8inx 1159 17 vs vs IN cord-010092-uftc8inx 1159 18 1.2 1.2 CD cord-010092-uftc8inx 1159 19 kb kb NNP cord-010092-uftc8inx 1159 20 ) ) -RRB- cord-010092-uftc8inx 1159 21 and and CC cord-010092-uftc8inx 1159 22 can can MD cord-010092-uftc8inx 1159 23 be be VB cord-010092-uftc8inx 1159 24 easily easily RB cord-010092-uftc8inx 1159 25 accommodated accommodate VBN cord-010092-uftc8inx 1159 26 in in IN cord-010092-uftc8inx 1159 27 GT GT NNP cord-010092-uftc8inx 1159 28 vectors vector NNS cord-010092-uftc8inx 1159 29 without without IN cord-010092-uftc8inx 1159 30 detrimentally detrimentally RB cord-010092-uftc8inx 1159 31 affecting affect VBG cord-010092-uftc8inx 1159 32 vector vector NN cord-010092-uftc8inx 1159 33 titers titer NNS cord-010092-uftc8inx 1159 34 . . . cord-010092-uftc8inx 1160 1 Aims aim VBZ cord-010092-uftc8inx 1160 2 : : : cord-010092-uftc8inx 1160 3 We -PRON- PRP cord-010092-uftc8inx 1160 4 aimed aim VBD cord-010092-uftc8inx 1160 5 to to TO cord-010092-uftc8inx 1160 6 test test VB cord-010092-uftc8inx 1160 7 whether whether IN cord-010092-uftc8inx 1160 8 A1 A1 NNP cord-010092-uftc8inx 1160 9 , , , cord-010092-uftc8inx 1160 10 one one CD cord-010092-uftc8inx 1160 11 of of IN cord-010092-uftc8inx 1160 12 the the DT cord-010092-uftc8inx 1160 13 newly newly RB cord-010092-uftc8inx 1160 14 discovered discover VBN cord-010092-uftc8inx 1160 15 CIs CIs NNP cord-010092-uftc8inx 1160 16 , , , cord-010092-uftc8inx 1160 17 could could MD cord-010092-uftc8inx 1160 18 reduce reduce VB cord-010092-uftc8inx 1160 19 vector vector NN cord-010092-uftc8inx 1160 20 - - HYPH cord-010092-uftc8inx 1160 21 mediated mediate VBN cord-010092-uftc8inx 1160 22 genotoxicity genotoxicity NN cord-010092-uftc8inx 1160 23 in in IN cord-010092-uftc8inx 1160 24 the the DT cord-010092-uftc8inx 1160 25 challenging challenging JJ cord-010092-uftc8inx 1160 26 context context NN cord-010092-uftc8inx 1160 27 of of IN cord-010092-uftc8inx 1160 28 SIN sin NN cord-010092-uftc8inx 1160 29 - - HYPH cord-010092-uftc8inx 1160 30 LVs lv NNS cord-010092-uftc8inx 1160 31 , , , cord-010092-uftc8inx 1160 32 by by IN cord-010092-uftc8inx 1160 33 insulating insulate VBG cord-010092-uftc8inx 1160 34 a a DT cord-010092-uftc8inx 1160 35 therapeutic therapeutic JJ cord-010092-uftc8inx 1160 36 globin globin NN cord-010092-uftc8inx 1160 37 - - HYPH cord-010092-uftc8inx 1160 38 vector vector NN cord-010092-uftc8inx 1160 39 . . . cord-010092-uftc8inx 1161 1 Methods method NNS cord-010092-uftc8inx 1161 2 : : : cord-010092-uftc8inx 1161 3 We -PRON- PRP cord-010092-uftc8inx 1161 4 tested test VBD cord-010092-uftc8inx 1161 5 the the DT cord-010092-uftc8inx 1161 6 genotoxicity genotoxicity NN cord-010092-uftc8inx 1161 7 effect effect NN cord-010092-uftc8inx 1161 8 in in IN cord-010092-uftc8inx 1161 9 the the DT cord-010092-uftc8inx 1161 10 IL-3-dependent il-3-dependent NN cord-010092-uftc8inx 1161 11 32D 32D NNP cord-010092-uftc8inx 1161 12 cells cell NNS cord-010092-uftc8inx 1161 13 , , , cord-010092-uftc8inx 1161 14 which which WDT cord-010092-uftc8inx 1161 15 upon upon IN cord-010092-uftc8inx 1161 16 transduction transduction NN cord-010092-uftc8inx 1161 17 with with IN cord-010092-uftc8inx 1161 18 oncogenic oncogenic JJ cord-010092-uftc8inx 1161 19 vectors vector NNS cord-010092-uftc8inx 1161 20 become become VBP cord-010092-uftc8inx 1161 21 IL-3-independent IL-3-independent '' cord-010092-uftc8inx 1161 22 , , , cord-010092-uftc8inx 1161 23 leading lead VBG cord-010092-uftc8inx 1161 24 to to IN cord-010092-uftc8inx 1161 25 transformation transformation NN cord-010092-uftc8inx 1161 26 . . . cord-010092-uftc8inx 1162 1 32D 32D NNP cord-010092-uftc8inx 1162 2 cells cell NNS cord-010092-uftc8inx 1162 3 were be VBD cord-010092-uftc8inx 1162 4 transduced transduce VBN cord-010092-uftc8inx 1162 5 with with IN cord-010092-uftc8inx 1162 6 SIN sin NN cord-010092-uftc8inx 1162 7 - - HYPH cord-010092-uftc8inx 1162 8 LVs lv NNS cord-010092-uftc8inx 1162 9 : : : cord-010092-uftc8inx 1162 10 the the DT cord-010092-uftc8inx 1162 11 b b NN cord-010092-uftc8inx 1162 12 - - HYPH cord-010092-uftc8inx 1162 13 globin globin NN cord-010092-uftc8inx 1162 14 - - HYPH cord-010092-uftc8inx 1162 15 ΤΝS9.3.55- τνs9.3.55- NN cord-010092-uftc8inx 1162 16 , , , cord-010092-uftc8inx 1162 17 the the DT cord-010092-uftc8inx 1162 18 insulated insulated JJ cord-010092-uftc8inx 1162 19 b b NN cord-010092-uftc8inx 1162 20 - - HYPH cord-010092-uftc8inx 1162 21 globin globin NN cord-010092-uftc8inx 1162 22 - - : cord-010092-uftc8inx 1162 23 A1-TNS9.3.55and a1-tns9.3.55and CD cord-010092-uftc8inx 1162 24 the the DT cord-010092-uftc8inx 1162 25 oncogenic oncogenic JJ cord-010092-uftc8inx 1162 26 SFFV SFFV NNP cord-010092-uftc8inx 1162 27 - - HYPH cord-010092-uftc8inx 1162 28 GFP gfp NN cord-010092-uftc8inx 1162 29 - - HYPH cord-010092-uftc8inx 1162 30 vector vector NN cord-010092-uftc8inx 1162 31 . . . cord-010092-uftc8inx 1163 1 Transduced transduced JJ cord-010092-uftc8inx 1163 2 cells cell NNS cord-010092-uftc8inx 1163 3 were be VBD cord-010092-uftc8inx 1163 4 expanded expand VBN cord-010092-uftc8inx 1163 5 in in IN cord-010092-uftc8inx 1163 6 10 10 CD cord-010092-uftc8inx 1163 7 % % NN cord-010092-uftc8inx 1163 8 IL-3 IL-3 NNP cord-010092-uftc8inx 1163 9 and and CC cord-010092-uftc8inx 1163 10 transduction transduction NN cord-010092-uftc8inx 1163 11 efficiency efficiency NN cord-010092-uftc8inx 1163 12 was be VBD cord-010092-uftc8inx 1163 13 determined determine VBN cord-010092-uftc8inx 1163 14 by by IN cord-010092-uftc8inx 1163 15 vector vector NN cord-010092-uftc8inx 1163 16 copy copy NN cord-010092-uftc8inx 1163 17 number number NN cord-010092-uftc8inx 1163 18 ( ( -LRB- cord-010092-uftc8inx 1163 19 VCN VCN NNP cord-010092-uftc8inx 1163 20 ) ) -RRB- cord-010092-uftc8inx 1163 21 . . . cord-010092-uftc8inx 1164 1 Transduced Transduced NNP cord-010092-uftc8inx 1164 2 32D 32d NN cord-010092-uftc8inx 1164 3 cells cell NNS cord-010092-uftc8inx 1164 4 were be VBD cord-010092-uftc8inx 1164 5 seeded seed VBN cord-010092-uftc8inx 1164 6 in in IN cord-010092-uftc8inx 1164 7 methylcellulose methylcellulose NN cord-010092-uftc8inx 1164 8 with with IN cord-010092-uftc8inx 1164 9 10 10 CD cord-010092-uftc8inx 1164 10 % % NN cord-010092-uftc8inx 1164 11 or or CC cord-010092-uftc8inx 1164 12 0 0 CD cord-010092-uftc8inx 1164 13 - - SYM cord-010092-uftc8inx 1164 14 1 1 CD cord-010092-uftc8inx 1164 15 % % NN cord-010092-uftc8inx 1164 16 IL-3 IL-3 NNP cord-010092-uftc8inx 1164 17 to to TO cord-010092-uftc8inx 1164 18 detect detect VB cord-010092-uftc8inx 1164 19 the the DT cord-010092-uftc8inx 1164 20 IL-3-independent IL-3-independent '' cord-010092-uftc8inx 1164 21 and and CC cord-010092-uftc8inx 1164 22 potentially potentially RB cord-010092-uftc8inx 1164 23 transformed transform VBN cord-010092-uftc8inx 1164 24 clones clone NNS cord-010092-uftc8inx 1164 25 . . . cord-010092-uftc8inx 1165 1 The the DT cord-010092-uftc8inx 1165 2 IL-3-independent IL-3-independent `` cord-010092-uftc8inx 1165 3 clones clone NNS cord-010092-uftc8inx 1165 4 were be VBD cord-010092-uftc8inx 1165 5 further further RB cord-010092-uftc8inx 1165 6 expanded expand VBN cord-010092-uftc8inx 1165 7 in in IN cord-010092-uftc8inx 1165 8 10 10 CD cord-010092-uftc8inx 1165 9 % % NN cord-010092-uftc8inx 1165 10 IL-3 IL-3 NNP cord-010092-uftc8inx 1165 11 and and CC cord-010092-uftc8inx 1165 12 infused infuse VBN cord-010092-uftc8inx 1165 13 in in IN cord-010092-uftc8inx 1165 14 partially partially RB cord-010092-uftc8inx 1165 15 myeloablated myeloablate VBN cord-010092-uftc8inx 1165 16 and and CC cord-010092-uftc8inx 1165 17 IL-3-treated il-3-treated CD cord-010092-uftc8inx 1165 18 C3H C3H NNP cord-010092-uftc8inx 1165 19 / / SYM cord-010092-uftc8inx 1165 20 HeJ hej NN cord-010092-uftc8inx 1165 21 mice mouse NNS cord-010092-uftc8inx 1165 22 . . . cord-010092-uftc8inx 1166 1 WBC WBC NNP cord-010092-uftc8inx 1166 2 analysis analysis NN cord-010092-uftc8inx 1166 3 , , , cord-010092-uftc8inx 1166 4 blood blood NN cord-010092-uftc8inx 1166 5 smears smear NNS cord-010092-uftc8inx 1166 6 and and CC cord-010092-uftc8inx 1166 7 bone bone NN cord-010092-uftc8inx 1166 8 marrow(BM marrow(bm ADD cord-010092-uftc8inx 1166 9 ) ) -RRB- cord-010092-uftc8inx 1167 1 cytospins cytospins NNP cord-010092-uftc8inx 1167 2 were be VBD cord-010092-uftc8inx 1167 3 performed perform VBN cord-010092-uftc8inx 1167 4 . . . cord-010092-uftc8inx 1168 1 Results result NNS cord-010092-uftc8inx 1168 2 : : : cord-010092-uftc8inx 1169 1 The the DT cord-010092-uftc8inx 1169 2 A1 A1 NNP cord-010092-uftc8inx 1169 3 insulator insulator NN cord-010092-uftc8inx 1169 4 did do VBD cord-010092-uftc8inx 1169 5 not not RB cord-010092-uftc8inx 1169 6 negatively negatively RB cord-010092-uftc8inx 1169 7 affect affect VB cord-010092-uftc8inx 1169 8 vector vector NN cord-010092-uftc8inx 1169 9 titers titer NNS cord-010092-uftc8inx 1169 10 ( ( -LRB- cord-010092-uftc8inx 1169 11 ΤΝS9.3.55 ΤΝS9.3.55 NNS cord-010092-uftc8inx 1169 12 , , , cord-010092-uftc8inx 1169 13 A1-TNS9.3.55 A1-TNS9.3.55 NNS cord-010092-uftc8inx 1169 14 , , , cord-010092-uftc8inx 1169 15 SFFV SFFV NNP cord-010092-uftc8inx 1169 16 - - HYPH cord-010092-uftc8inx 1169 17 GFP GFP NNP cord-010092-uftc8inx 1169 18 : : : cord-010092-uftc8inx 1169 19 2.8 2.8 CD cord-010092-uftc8inx 1169 20 , , , cord-010092-uftc8inx 1169 21 1.8 1.8 CD cord-010092-uftc8inx 1169 22 , , , cord-010092-uftc8inx 1169 23 2.5X10 2.5x10 CD cord-010092-uftc8inx 1169 24 ^ ^ SYM cord-010092-uftc8inx 1169 25 8 8 CD cord-010092-uftc8inx 1169 26 IU IU NNP cord-010092-uftc8inx 1169 27 / / SYM cord-010092-uftc8inx 1169 28 ml ml NNS cord-010092-uftc8inx 1169 29 , , , cord-010092-uftc8inx 1169 30 respectively respectively RB cord-010092-uftc8inx 1169 31 ) ) -RRB- cord-010092-uftc8inx 1169 32 . . . cord-010092-uftc8inx 1170 1 32D 32D NNP cord-010092-uftc8inx 1170 2 cells cell NNS cord-010092-uftc8inx 1170 3 were be VBD cord-010092-uftc8inx 1170 4 successfully successfully RB cord-010092-uftc8inx 1170 5 transduced transduce VBN cord-010092-uftc8inx 1170 6 with with IN cord-010092-uftc8inx 1170 7 all all DT cord-010092-uftc8inx 1170 8 vectors vector NNS cord-010092-uftc8inx 1170 9 ( ( -LRB- cord-010092-uftc8inx 1170 10 % % NN cord-010092-uftc8inx 1170 11 VCN vcn NN cord-010092-uftc8inx 1170 12 positive positive JJ cord-010092-uftc8inx 1170 13 colonies colony NNS cord-010092-uftc8inx 1170 14 : : : cord-010092-uftc8inx 1170 15 40 40 CD cord-010092-uftc8inx 1170 16 - - SYM cord-010092-uftc8inx 1170 17 100 100 CD cord-010092-uftc8inx 1170 18 % % NN cord-010092-uftc8inx 1170 19 ) ) -RRB- cord-010092-uftc8inx 1170 20 and and CC cord-010092-uftc8inx 1170 21 expanded expand VBD cord-010092-uftc8inx 1170 22 up up IN cord-010092-uftc8inx 1170 23 to to IN cord-010092-uftc8inx 1170 24 400-fold 400-fold CD cord-010092-uftc8inx 1170 25 . . . cord-010092-uftc8inx 1171 1 The the DT cord-010092-uftc8inx 1171 2 A1-insulator A1-insulator NNS cord-010092-uftc8inx 1171 3 decreased decrease VBD cord-010092-uftc8inx 1171 4 the the DT cord-010092-uftc8inx 1171 5 number number NN cord-010092-uftc8inx 1171 6 of of IN cord-010092-uftc8inx 1171 7 IL-3-independent il-3-independent NN cord-010092-uftc8inx 1171 8 colonies colony NNS cord-010092-uftc8inx 1171 9 by by IN cord-010092-uftc8inx 1171 10 78 78 CD cord-010092-uftc8inx 1171 11 - - SYM cord-010092-uftc8inx 1171 12 93 93 CD cord-010092-uftc8inx 1171 13 % % NN cord-010092-uftc8inx 1171 14 over over IN cord-010092-uftc8inx 1171 15 the the DT cord-010092-uftc8inx 1171 16 uninsulated uninsulated JJ cord-010092-uftc8inx 1171 17 vectors vector NNS cord-010092-uftc8inx 1171 18 . . . cord-010092-uftc8inx 1172 1 The the DT cord-010092-uftc8inx 1172 2 uninsulated uninsulated JJ cord-010092-uftc8inx 1172 3 vector vector NN cord-010092-uftc8inx 1172 4 - - HYPH cord-010092-uftc8inx 1172 5 transduced transduce VBN cord-010092-uftc8inx 1172 6 , , , cord-010092-uftc8inx 1172 7 IL-3-independent IL-3-independent '' cord-010092-uftc8inx 1172 8 colonies colony NNS cord-010092-uftc8inx 1172 9 , , , cord-010092-uftc8inx 1172 10 were be VBD cord-010092-uftc8inx 1172 11 greatly greatly RB cord-010092-uftc8inx 1172 12 expanded expand VBN cord-010092-uftc8inx 1172 13 in in IN cord-010092-uftc8inx 1172 14 culture culture NN cord-010092-uftc8inx 1172 15 with with IN cord-010092-uftc8inx 1172 16 10 10 CD cord-010092-uftc8inx 1172 17 % % NN cord-010092-uftc8inx 1172 18 IL-3 IL-3 NNP cord-010092-uftc8inx 1172 19 over over IN cord-010092-uftc8inx 1172 20 the the DT cord-010092-uftc8inx 1172 21 A1-transduced a1-transduce VBN cord-010092-uftc8inx 1172 22 colonies colony NNS cord-010092-uftc8inx 1172 23 ( ( -LRB- cord-010092-uftc8inx 1172 24 SFFV SFFV NNP cord-010092-uftc8inx 1172 25 , , , cord-010092-uftc8inx 1172 26 ΤΝS9.3.55 ΤΝS9.3.55 NNS cord-010092-uftc8inx 1172 27 , , , cord-010092-uftc8inx 1172 28 A1-TNS9.3.55 a1-tns9.3.55 CD cord-010092-uftc8inx 1172 29 : : : cord-010092-uftc8inx 1172 30 48 48 CD cord-010092-uftc8inx 1172 31 , , , cord-010092-uftc8inx 1172 32 40 40 CD cord-010092-uftc8inx 1172 33 , , , cord-010092-uftc8inx 1172 34 10 10 CD cord-010092-uftc8inx 1172 35 fold fold NN cord-010092-uftc8inx 1172 36 change change NN cord-010092-uftc8inx 1172 37 , , , cord-010092-uftc8inx 1172 38 respectively respectively RB cord-010092-uftc8inx 1172 39 ) ) -RRB- cord-010092-uftc8inx 1172 40 . . . cord-010092-uftc8inx 1173 1 IL-3 IL-3 NNP cord-010092-uftc8inx 1173 2 independence independence NN cord-010092-uftc8inx 1173 3 as as IN cord-010092-uftc8inx 1173 4 a a DT cord-010092-uftc8inx 1173 5 transformation transformation NN cord-010092-uftc8inx 1173 6 event event NN cord-010092-uftc8inx 1173 7 was be VBD cord-010092-uftc8inx 1173 8 confirmed confirm VBN cord-010092-uftc8inx 1173 9 in in IN cord-010092-uftc8inx 1173 10 vivo vivo NN cord-010092-uftc8inx 1173 11 by by IN cord-010092-uftc8inx 1173 12 the the DT cord-010092-uftc8inx 1173 13 development development NN cord-010092-uftc8inx 1173 14 of of IN cord-010092-uftc8inx 1173 15 overt overt JJ cord-010092-uftc8inx 1173 16 leukemia leukemia NN cord-010092-uftc8inx 1173 17 ( ( -LRB- cord-010092-uftc8inx 1173 18 hyperleukocytosis hyperleukocytosis NNP cord-010092-uftc8inx 1173 19 , , , cord-010092-uftc8inx 1173 20 splenomegaly splenomegaly NN cord-010092-uftc8inx 1173 21 , , , cord-010092-uftc8inx 1173 22 BM BM NNP cord-010092-uftc8inx 1173 23 - - HYPH cord-010092-uftc8inx 1173 24 and and CC cord-010092-uftc8inx 1173 25 extramedullary extramedullary JJ cord-010092-uftc8inx 1173 26 site site NN cord-010092-uftc8inx 1173 27 - - HYPH cord-010092-uftc8inx 1173 28 infiltration infiltration NN cord-010092-uftc8inx 1173 29 ) ) -RRB- cord-010092-uftc8inx 1173 30 in in IN cord-010092-uftc8inx 1173 31 mice mouse NNS cord-010092-uftc8inx 1173 32 transplanted transplant VBN cord-010092-uftc8inx 1173 33 with with IN cord-010092-uftc8inx 1173 34 the the DT cord-010092-uftc8inx 1173 35 IL-3-independent il-3-independent CD cord-010092-uftc8inx 1173 36 and and CC cord-010092-uftc8inx 1173 37 expanded expand VBN cord-010092-uftc8inx 1173 38 colonies colony NNS cord-010092-uftc8inx 1173 39 . . . cord-010092-uftc8inx 1174 1 Summary Summary NNP cord-010092-uftc8inx 1174 2 / / SYM cord-010092-uftc8inx 1174 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 1174 4 : : : cord-010092-uftc8inx 1175 1 Under under IN cord-010092-uftc8inx 1175 2 forced force VBN cord-010092-uftc8inx 1175 3 oncogenic oncogenic JJ cord-010092-uftc8inx 1175 4 conditions condition NNS cord-010092-uftc8inx 1175 5 , , , cord-010092-uftc8inx 1175 6 the the DT cord-010092-uftc8inx 1175 7 A1 A1 NNP cord-010092-uftc8inx 1175 8 insulator insulator NN cord-010092-uftc8inx 1175 9 effectively effectively RB cord-010092-uftc8inx 1175 10 protected protect VBD cord-010092-uftc8inx 1175 11 a a DT cord-010092-uftc8inx 1175 12 therapeutic therapeutic JJ cord-010092-uftc8inx 1175 13 vector vector NN cord-010092-uftc8inx 1175 14 from from IN cord-010092-uftc8inx 1175 15 vector vector NN cord-010092-uftc8inx 1175 16 - - HYPH cord-010092-uftc8inx 1175 17 mediated mediate VBN cord-010092-uftc8inx 1175 18 genotoxicity genotoxicity NN cord-010092-uftc8inx 1175 19 . . . cord-010092-uftc8inx 1176 1 A1 A1 NNP cord-010092-uftc8inx 1176 2 may may MD cord-010092-uftc8inx 1176 3 serve serve VB cord-010092-uftc8inx 1176 4 as as IN cord-010092-uftc8inx 1176 5 a a DT cord-010092-uftc8inx 1176 6 safety safety NN cord-010092-uftc8inx 1176 7 feature feature NN cord-010092-uftc8inx 1176 8 in in IN cord-010092-uftc8inx 1176 9 the the DT cord-010092-uftc8inx 1176 10 construction construction NN cord-010092-uftc8inx 1176 11 of of IN cord-010092-uftc8inx 1176 12 globin globin NN cord-010092-uftc8inx 1176 13 - - HYPH cord-010092-uftc8inx 1176 14 SIN sin NN cord-010092-uftc8inx 1176 15 - - HYPH cord-010092-uftc8inx 1176 16 LVs lv NNS cord-010092-uftc8inx 1176 17 . . . cord-010092-uftc8inx 1177 1 Background background NN cord-010092-uftc8inx 1177 2 : : : cord-010092-uftc8inx 1178 1 Novel novel JJ cord-010092-uftc8inx 1178 2 rare rare JJ cord-010092-uftc8inx 1178 3 nucleotide nucleotide JJ cord-010092-uftc8inx 1178 4 substitutions substitution NNS cord-010092-uftc8inx 1178 5 are be VBP cord-010092-uftc8inx 1178 6 frequently frequently RB cord-010092-uftc8inx 1178 7 identified identify VBN cord-010092-uftc8inx 1178 8 in in IN cord-010092-uftc8inx 1178 9 RHD RHD NNP cord-010092-uftc8inx 1178 10 , , , cord-010092-uftc8inx 1179 1 the the DT cord-010092-uftc8inx 1179 2 gene gene NN cord-010092-uftc8inx 1179 3 encoding encode VBG cord-010092-uftc8inx 1179 4 the the DT cord-010092-uftc8inx 1179 5 immunogenic immunogenic JJ cord-010092-uftc8inx 1179 6 D d NN cord-010092-uftc8inx 1179 7 antigen antigen NN cord-010092-uftc8inx 1179 8 of of IN cord-010092-uftc8inx 1179 9 the the DT cord-010092-uftc8inx 1179 10 clinically clinically RB cord-010092-uftc8inx 1179 11 - - HYPH cord-010092-uftc8inx 1179 12 relevant relevant JJ cord-010092-uftc8inx 1179 13 Rh Rh NNP cord-010092-uftc8inx 1179 14 blood blood NN cord-010092-uftc8inx 1179 15 group group NN cord-010092-uftc8inx 1179 16 system system NN cord-010092-uftc8inx 1179 17 , , , cord-010092-uftc8inx 1179 18 resulting result VBG cord-010092-uftc8inx 1179 19 in in IN cord-010092-uftc8inx 1179 20 D d NN cord-010092-uftc8inx 1179 21 variant variant NN cord-010092-uftc8inx 1179 22 phenotype phenotype NN cord-010092-uftc8inx 1179 23 . . . cord-010092-uftc8inx 1180 1 So so RB cord-010092-uftc8inx 1180 2 far far RB cord-010092-uftc8inx 1180 3 , , , cord-010092-uftc8inx 1180 4 it -PRON- PRP cord-010092-uftc8inx 1180 5 has have VBZ cord-010092-uftc8inx 1180 6 been be VBN cord-010092-uftc8inx 1180 7 commonly commonly RB cord-010092-uftc8inx 1180 8 accepted accept VBN cord-010092-uftc8inx 1180 9 that that IN cord-010092-uftc8inx 1180 10 substitutions substitution NNS cord-010092-uftc8inx 1180 11 of of IN cord-010092-uftc8inx 1180 12 amino amino JJ cord-010092-uftc8inx 1180 13 acids acid NNS cord-010092-uftc8inx 1180 14 located locate VBN cord-010092-uftc8inx 1180 15 either either CC cord-010092-uftc8inx 1180 16 in in IN cord-010092-uftc8inx 1180 17 a a DT cord-010092-uftc8inx 1180 18 transmembrane transmembrane NN cord-010092-uftc8inx 1180 19 or or CC cord-010092-uftc8inx 1180 20 intracellular intracellular JJ cord-010092-uftc8inx 1180 21 domain domain NN cord-010092-uftc8inx 1180 22 of of IN cord-010092-uftc8inx 1180 23 the the DT cord-010092-uftc8inx 1180 24 RhD RhD NNP cord-010092-uftc8inx 1180 25 protein protein NN cord-010092-uftc8inx 1180 26 induce induce VBP cord-010092-uftc8inx 1180 27 weak weak JJ cord-010092-uftc8inx 1180 28 D d NN cord-010092-uftc8inx 1180 29 phenotype phenotype NN cord-010092-uftc8inx 1180 30 , , , cord-010092-uftc8inx 1180 31 i.e. i.e. FW cord-010092-uftc8inx 1180 32 reduced reduce VBN cord-010092-uftc8inx 1180 33 D d NN cord-010092-uftc8inx 1180 34 antigen antigen NN cord-010092-uftc8inx 1180 35 density density NN cord-010092-uftc8inx 1180 36 at at IN cord-010092-uftc8inx 1180 37 the the DT cord-010092-uftc8inx 1180 38 surface surface NN cord-010092-uftc8inx 1180 39 of of IN cord-010092-uftc8inx 1180 40 red red JJ cord-010092-uftc8inx 1180 41 blood blood NN cord-010092-uftc8inx 1180 42 cells cell NNS cord-010092-uftc8inx 1180 43 . . . cord-010092-uftc8inx 1181 1 Recently recently RB cord-010092-uftc8inx 1181 2 we -PRON- PRP cord-010092-uftc8inx 1181 3 showed show VBD cord-010092-uftc8inx 1181 4 by by IN cord-010092-uftc8inx 1181 5 functional functional JJ cord-010092-uftc8inx 1181 6 analysis analysis NN cord-010092-uftc8inx 1181 7 using use VBG cord-010092-uftc8inx 1181 8 a a DT cord-010092-uftc8inx 1181 9 " " `` cord-010092-uftc8inx 1181 10 minigene minigene NN cord-010092-uftc8inx 1181 11 splicing splicing NN cord-010092-uftc8inx 1181 12 assay assay NN cord-010092-uftc8inx 1181 13 " " '' cord-010092-uftc8inx 1181 14 ( ( -LRB- cord-010092-uftc8inx 1181 15 MSA MSA NNP cord-010092-uftc8inx 1181 16 ) ) -RRB- cord-010092-uftc8inx 1181 17 that that IN cord-010092-uftc8inx 1181 18 a a DT cord-010092-uftc8inx 1181 19 decrease decrease NN cord-010092-uftc8inx 1181 20 in in IN cord-010092-uftc8inx 1181 21 D D NNP cord-010092-uftc8inx 1181 22 antigen antigen NN cord-010092-uftc8inx 1181 23 expression expression NN cord-010092-uftc8inx 1181 24 may may MD cord-010092-uftc8inx 1181 25 be be VB cord-010092-uftc8inx 1181 26 due due JJ cord-010092-uftc8inx 1181 27 also also RB cord-010092-uftc8inx 1181 28 to to IN cord-010092-uftc8inx 1181 29 alteration alteration NN cord-010092-uftc8inx 1181 30 of of IN cord-010092-uftc8inx 1181 31 cellular cellular JJ cord-010092-uftc8inx 1181 32 splicing splicing NN cord-010092-uftc8inx 1181 33 . . . cord-010092-uftc8inx 1182 1 Aims aim VBZ cord-010092-uftc8inx 1182 2 : : : cord-010092-uftc8inx 1183 1 Here here RB cord-010092-uftc8inx 1183 2 we -PRON- PRP cord-010092-uftc8inx 1183 3 pay pay VBP cord-010092-uftc8inx 1183 4 attention attention NN cord-010092-uftc8inx 1183 5 to to IN cord-010092-uftc8inx 1183 6 the the DT cord-010092-uftc8inx 1183 7 general general JJ cord-010092-uftc8inx 1183 8 disruption disruption NN cord-010092-uftc8inx 1183 9 of of IN cord-010092-uftc8inx 1183 10 this this DT cord-010092-uftc8inx 1183 11 mechanism mechanism NN cord-010092-uftc8inx 1183 12 and and CC cord-010092-uftc8inx 1183 13 the the DT cord-010092-uftc8inx 1183 14 related relate VBN cord-010092-uftc8inx 1183 15 phenotypic phenotypic JJ cord-010092-uftc8inx 1183 16 consequences consequence NNS cord-010092-uftc8inx 1183 17 in in IN cord-010092-uftc8inx 1183 18 novel novel NN cord-010092-uftc8inx 1183 19 and and CC cord-010092-uftc8inx 1183 20 previously previously RB cord-010092-uftc8inx 1183 21 reported report VBN cord-010092-uftc8inx 1183 22 single single JJ cord-010092-uftc8inx 1183 23 - - HYPH cord-010092-uftc8inx 1183 24 nucleotide nucleotide NN cord-010092-uftc8inx 1183 25 variations variation NNS cord-010092-uftc8inx 1183 26 in in IN cord-010092-uftc8inx 1183 27 RHD RHD NNP cord-010092-uftc8inx 1183 28 . . . cord-010092-uftc8inx 1184 1 We -PRON- PRP cord-010092-uftc8inx 1184 2 then then RB cord-010092-uftc8inx 1184 3 sought seek VBD cord-010092-uftc8inx 1184 4 to to TO cord-010092-uftc8inx 1184 5 characterize characterize VB cord-010092-uftc8inx 1184 6 functionally functionally RB cord-010092-uftc8inx 1184 7 by by IN cord-010092-uftc8inx 1184 8 MSA MSA NNP cord-010092-uftc8inx 1184 9 novel novel NN cord-010092-uftc8inx 1184 10 candidate candidate NN cord-010092-uftc8inx 1184 11 splicing splicing NN cord-010092-uftc8inx 1184 12 variants variant NNS cord-010092-uftc8inx 1184 13 in in IN cord-010092-uftc8inx 1184 14 RHD RHD NNP cord-010092-uftc8inx 1184 15 . . . cord-010092-uftc8inx 1185 1 Then then RB cord-010092-uftc8inx 1185 2 we -PRON- PRP cord-010092-uftc8inx 1185 3 extended extend VBD cord-010092-uftc8inx 1185 4 the the DT cord-010092-uftc8inx 1185 5 project project NN cord-010092-uftc8inx 1185 6 by by IN cord-010092-uftc8inx 1185 7 studying study VBG cord-010092-uftc8inx 1185 8 prospectively prospectively RB cord-010092-uftc8inx 1185 9 all all DT cord-010092-uftc8inx 1185 10 single single JJ cord-010092-uftc8inx 1185 11 - - HYPH cord-010092-uftc8inx 1185 12 nucleotide nucleotide NN cord-010092-uftc8inx 1185 13 variations variation NNS cord-010092-uftc8inx 1185 14 reported report VBN cord-010092-uftc8inx 1185 15 in in IN cord-010092-uftc8inx 1185 16 RHD RHD NNP cord-010092-uftc8inx 1185 17 exons exon NNS cord-010092-uftc8inx 1185 18 , , , cord-010092-uftc8inx 1185 19 in in IN cord-010092-uftc8inx 1185 20 order order NN cord-010092-uftc8inx 1185 21 to to TO cord-010092-uftc8inx 1185 22 assess assess VB cord-010092-uftc8inx 1185 23 globally globally RB cord-010092-uftc8inx 1185 24 the the DT cord-010092-uftc8inx 1185 25 correlation correlation NN cord-010092-uftc8inx 1185 26 between between IN cord-010092-uftc8inx 1185 27 in in IN cord-010092-uftc8inx 1185 28 silico silico NN cord-010092-uftc8inx 1185 29 prediction prediction NN cord-010092-uftc8inx 1185 30 and and CC cord-010092-uftc8inx 1185 31 functional functional JJ cord-010092-uftc8inx 1185 32 analysis analysis NN cord-010092-uftc8inx 1185 33 and and CC cord-010092-uftc8inx 1185 34 to to TO cord-010092-uftc8inx 1185 35 gain gain VB cord-010092-uftc8inx 1185 36 insights insight NNS cord-010092-uftc8inx 1185 37 into into IN cord-010092-uftc8inx 1185 38 the the DT cord-010092-uftc8inx 1185 39 reliability reliability NN cord-010092-uftc8inx 1185 40 of of IN cord-010092-uftc8inx 1185 41 bioinformatics bioinformatics NN cord-010092-uftc8inx 1185 42 tools tool NNS cord-010092-uftc8inx 1185 43 in in IN cord-010092-uftc8inx 1185 44 line line NN cord-010092-uftc8inx 1185 45 with with IN cord-010092-uftc8inx 1185 46 the the DT cord-010092-uftc8inx 1185 47 available available JJ cord-010092-uftc8inx 1185 48 phenotypic phenotypic NNS cord-010092-uftc8inx 1185 49 and/or and/or CC cord-010092-uftc8inx 1185 50 clinical clinical JJ cord-010092-uftc8inx 1185 51 data datum NNS cord-010092-uftc8inx 1185 52 . . . cord-010092-uftc8inx 1186 1 Methods method NNS cord-010092-uftc8inx 1186 2 : : : cord-010092-uftc8inx 1187 1 Seventeen seventeen CD cord-010092-uftc8inx 1187 2 novel novel JJ cord-010092-uftc8inx 1187 3 or or CC cord-010092-uftc8inx 1187 4 uncharacterized uncharacterized JJ cord-010092-uftc8inx 1187 5 RHD RHD NNP cord-010092-uftc8inx 1187 6 variations variation NNS cord-010092-uftc8inx 1187 7 , , , cord-010092-uftc8inx 1187 8 including include VBG cord-010092-uftc8inx 1187 9 missense missense NN cord-010092-uftc8inx 1187 10 , , , cord-010092-uftc8inx 1187 11 synonymous synonymous JJ cord-010092-uftc8inx 1187 12 and and CC cord-010092-uftc8inx 1187 13 intronic intronic JJ cord-010092-uftc8inx 1187 14 substitutions substitution NNS cord-010092-uftc8inx 1187 15 , , , cord-010092-uftc8inx 1187 16 were be VBD cord-010092-uftc8inx 1187 17 selected select VBN cord-010092-uftc8inx 1187 18 for for IN cord-010092-uftc8inx 1187 19 functional functional JJ cord-010092-uftc8inx 1187 20 analysis analysis NN cord-010092-uftc8inx 1187 21 by by IN cord-010092-uftc8inx 1187 22 MSA MSA NNP cord-010092-uftc8inx 1187 23 in in IN cord-010092-uftc8inx 1187 24 human human JJ cord-010092-uftc8inx 1187 25 cell cell NN cord-010092-uftc8inx 1187 26 models model NNS cord-010092-uftc8inx 1187 27 . . . cord-010092-uftc8inx 1188 1 A a DT cord-010092-uftc8inx 1188 2 second second JJ cord-010092-uftc8inx 1188 3 set set NN cord-010092-uftc8inx 1188 4 , , , cord-010092-uftc8inx 1188 5 including include VBG cord-010092-uftc8inx 1188 6 46 46 CD cord-010092-uftc8inx 1188 7 missense missense NN cord-010092-uftc8inx 1188 8 variants variant NNS cord-010092-uftc8inx 1188 9 reported report VBN cord-010092-uftc8inx 1188 10 in in IN cord-010092-uftc8inx 1188 11 RHD RHD NNP cord-010092-uftc8inx 1188 12 exons exon NNS cord-010092-uftc8inx 1188 13 6 6 CD cord-010092-uftc8inx 1188 14 and and CC cord-010092-uftc8inx 1188 15 7 7 CD cord-010092-uftc8inx 1188 16 , , , cord-010092-uftc8inx 1188 17 was be VBD cord-010092-uftc8inx 1188 18 further further RB cord-010092-uftc8inx 1188 19 analyzed analyze VBN cord-010092-uftc8inx 1188 20 . . . cord-010092-uftc8inx 1189 1 Functional functional JJ cord-010092-uftc8inx 1189 2 data datum NNS cord-010092-uftc8inx 1189 3 were be VBD cord-010092-uftc8inx 1189 4 compared compare VBN cord-010092-uftc8inx 1189 5 with with IN cord-010092-uftc8inx 1189 6 an an DT cord-010092-uftc8inx 1189 7 algorithm algorithm NN cord-010092-uftc8inx 1189 8 derived derive VBN cord-010092-uftc8inx 1189 9 from from IN cord-010092-uftc8inx 1189 10 the the DT cord-010092-uftc8inx 1189 11 QUEPASA QUEPASA NNP cord-010092-uftc8inx 1189 12 method method NN cord-010092-uftc8inx 1189 13 and and CC cord-010092-uftc8inx 1189 14 tools tool NNS cord-010092-uftc8inx 1189 15 available available JJ cord-010092-uftc8inx 1189 16 in in IN cord-010092-uftc8inx 1189 17 the the DT cord-010092-uftc8inx 1189 18 Alamut Alamut NNP cord-010092-uftc8inx 1189 19 suite suite NN cord-010092-uftc8inx 1189 20 . . . cord-010092-uftc8inx 1190 1 A a DT cord-010092-uftc8inx 1190 2 published publish VBN cord-010092-uftc8inx 1190 3 3D 3d JJ cord-010092-uftc8inx 1190 4 protein protein NN cord-010092-uftc8inx 1190 5 model model NN cord-010092-uftc8inx 1190 6 was be VBD cord-010092-uftc8inx 1190 7 used use VBN cord-010092-uftc8inx 1190 8 to to TO cord-010092-uftc8inx 1190 9 visualize visualize VB cord-010092-uftc8inx 1190 10 the the DT cord-010092-uftc8inx 1190 11 location location NN cord-010092-uftc8inx 1190 12 of of IN cord-010092-uftc8inx 1190 13 missense missense JJ cord-010092-uftc8inx 1190 14 amino amino NN cord-010092-uftc8inx 1190 15 acid acid NN cord-010092-uftc8inx 1190 16 substitutions substitution NNS cord-010092-uftc8inx 1190 17 and and CC cord-010092-uftc8inx 1190 18 to to TO cord-010092-uftc8inx 1190 19 assess assess VB cord-010092-uftc8inx 1190 20 potentially potentially RB cord-010092-uftc8inx 1190 21 their -PRON- PRP$ cord-010092-uftc8inx 1190 22 respective respective JJ cord-010092-uftc8inx 1190 23 phenotypic phenotypic JJ cord-010092-uftc8inx 1190 24 consequence consequence NN cord-010092-uftc8inx 1190 25 . . . cord-010092-uftc8inx 1191 1 Results result NNS cord-010092-uftc8inx 1191 2 : : : cord-010092-uftc8inx 1191 3 A a DT cord-010092-uftc8inx 1191 4 novel novel JJ cord-010092-uftc8inx 1191 5 " " `` cord-010092-uftc8inx 1191 6 universal universal JJ cord-010092-uftc8inx 1191 7 " " '' cord-010092-uftc8inx 1191 8 minigene minigene NN cord-010092-uftc8inx 1191 9 was be VBD cord-010092-uftc8inx 1191 10 validated validate VBN cord-010092-uftc8inx 1191 11 and and CC cord-010092-uftc8inx 1191 12 used use VBN cord-010092-uftc8inx 1191 13 successfully successfully RB cord-010092-uftc8inx 1191 14 to to TO cord-010092-uftc8inx 1191 15 characterize characterize VB cord-010092-uftc8inx 1191 16 eleven eleven CD cord-010092-uftc8inx 1191 17 novel novel NN cord-010092-uftc8inx 1191 18 splicing splicing NN cord-010092-uftc8inx 1191 19 variants variant NNS cord-010092-uftc8inx 1191 20 . . . cord-010092-uftc8inx 1192 1 Those those DT cord-010092-uftc8inx 1192 2 variants variant NNS cord-010092-uftc8inx 1192 3 include include VBP cord-010092-uftc8inx 1192 4 six six CD cord-010092-uftc8inx 1192 5 intronic intronic JJ cord-010092-uftc8inx 1192 6 and and CC cord-010092-uftc8inx 1192 7 four four CD cord-010092-uftc8inx 1192 8 missense missense NN cord-010092-uftc8inx 1192 9 substitutions substitution NNS cord-010092-uftc8inx 1192 10 close close JJ cord-010092-uftc8inx 1192 11 to to IN cord-010092-uftc8inx 1192 12 the the DT cord-010092-uftc8inx 1192 13 consensus consensus NN cord-010092-uftc8inx 1192 14 dinucleotide dinucleotide NN cord-010092-uftc8inx 1192 15 splice splice NN cord-010092-uftc8inx 1192 16 sites site NNS cord-010092-uftc8inx 1192 17 , , , cord-010092-uftc8inx 1192 18 as as RB cord-010092-uftc8inx 1192 19 well well RB cord-010092-uftc8inx 1192 20 as as IN cord-010092-uftc8inx 1192 21 the the DT cord-010092-uftc8inx 1192 22 c.1065C c.1065c CD cord-010092-uftc8inx 1193 1 > > XX cord-010092-uftc8inx 1193 2 T T NNP cord-010092-uftc8inx 1193 3 synonymous synonymous JJ cord-010092-uftc8inx 1193 4 variation variation NN cord-010092-uftc8inx 1193 5 associated associate VBN cord-010092-uftc8inx 1193 6 with with IN cord-010092-uftc8inx 1193 7 a a DT cord-010092-uftc8inx 1193 8 weak weak JJ cord-010092-uftc8inx 1193 9 D d NN cord-010092-uftc8inx 1193 10 phenotype phenotype NN cord-010092-uftc8inx 1193 11 , , , cord-010092-uftc8inx 1193 12 which which WDT cord-010092-uftc8inx 1193 13 creates create VBZ cord-010092-uftc8inx 1193 14 a a DT cord-010092-uftc8inx 1193 15 de de FW cord-010092-uftc8inx 1193 16 novo novo NNP cord-010092-uftc8inx 1193 17 splice splice NN cord-010092-uftc8inx 1193 18 site site NN cord-010092-uftc8inx 1193 19 . . . cord-010092-uftc8inx 1194 1 Very very RB cord-010092-uftc8inx 1194 2 interestingly interestingly RB cord-010092-uftc8inx 1194 3 , , , cord-010092-uftc8inx 1194 4 c.1154 c.1154 NNS cord-010092-uftc8inx 1194 5 G g NN cord-010092-uftc8inx 1194 6 > > XX cord-010092-uftc8inx 1195 1 T T NNP cord-010092-uftc8inx 1195 2 ( ( -LRB- cord-010092-uftc8inx 1195 3 Gly385Val gly385val NN cord-010092-uftc8inx 1195 4 ; ; : cord-010092-uftc8inx 1195 5 D d JJ cord-010092-uftc8inx 1195 6 - - HYPH cord-010092-uftc8inx 1195 7 negative negative JJ cord-010092-uftc8inx 1195 8 ) ) -RRB- cord-010092-uftc8inx 1195 9 disrupts disrupt VBZ cord-010092-uftc8inx 1195 10 totally totally RB cord-010092-uftc8inx 1195 11 normal normal JJ cord-010092-uftc8inx 1195 12 splicing splicing NN cord-010092-uftc8inx 1195 13 , , , cord-010092-uftc8inx 1195 14 while while IN cord-010092-uftc8inx 1195 15 c.1154 c.1154 NNS cord-010092-uftc8inx 1195 16 G G NNP cord-010092-uftc8inx 1196 1 > > XX cord-010092-uftc8inx 1197 1 C C NNP cord-010092-uftc8inx 1197 2 ( ( -LRB- cord-010092-uftc8inx 1197 3 Gly385Ala Gly385Ala NNS cord-010092-uftc8inx 1197 4 ; ; : cord-010092-uftc8inx 1197 5 weak weak JJ cord-010092-uftc8inx 1197 6 D D NNP cord-010092-uftc8inx 1197 7 ) ) -RRB- cord-010092-uftc8inx 1197 8 and and CC cord-010092-uftc8inx 1197 9 c.1154 c.1154 NNS cord-010092-uftc8inx 1197 10 G g NN cord-010092-uftc8inx 1197 11 > > XX cord-010092-uftc8inx 1198 1 A a DT cord-010092-uftc8inx 1199 1 ( ( -LRB- cord-010092-uftc8inx 1199 2 Gly385Asp gly385asp XX cord-010092-uftc8inx 1199 3 ; ; : cord-010092-uftc8inx 1199 4 D d JJ cord-010092-uftc8inx 1199 5 - - HYPH cord-010092-uftc8inx 1199 6 negative negative JJ cord-010092-uftc8inx 1199 7 ) ) -RRB- cord-010092-uftc8inx 1199 8 only only RB cord-010092-uftc8inx 1199 9 partially partially RB cord-010092-uftc8inx 1199 10 alter alter VB cord-010092-uftc8inx 1199 11 the the DT cord-010092-uftc8inx 1199 12 mechanism mechanism NN cord-010092-uftc8inx 1199 13 . . . cord-010092-uftc8inx 1200 1 Further further JJ cord-010092-uftc8inx 1200 2 visualization visualization NN cord-010092-uftc8inx 1200 3 of of IN cord-010092-uftc8inx 1200 4 amino amino NN cord-010092-uftc8inx 1200 5 acid acid NN cord-010092-uftc8inx 1200 6 changes change NNS cord-010092-uftc8inx 1200 7 in in IN cord-010092-uftc8inx 1200 8 a a DT cord-010092-uftc8inx 1200 9 3D 3d JJ cord-010092-uftc8inx 1200 10 model model NN cord-010092-uftc8inx 1200 11 suggests suggest VBZ cord-010092-uftc8inx 1200 12 that that IN cord-010092-uftc8inx 1200 13 Gly385Asp Gly385Asp NNP cord-010092-uftc8inx 1200 14 , , , cord-010092-uftc8inx 1200 15 but but CC cord-010092-uftc8inx 1200 16 not not RB cord-010092-uftc8inx 1200 17 Gly385Ala gly385ala XX cord-010092-uftc8inx 1200 18 , , , cord-010092-uftc8inx 1200 19 dramatically dramatically RB cord-010092-uftc8inx 1200 20 impair impair VB cord-010092-uftc8inx 1200 21 RhD rhd NN cord-010092-uftc8inx 1200 22 protein protein NN cord-010092-uftc8inx 1200 23 structure structure NN cord-010092-uftc8inx 1200 24 / / SYM cord-010092-uftc8inx 1200 25 folding folding NN cord-010092-uftc8inx 1200 26 . . . cord-010092-uftc8inx 1201 1 Subsequently subsequently RB cord-010092-uftc8inx 1201 2 the the DT cord-010092-uftc8inx 1201 3 global global JJ cord-010092-uftc8inx 1201 4 analysis analysis NN cord-010092-uftc8inx 1201 5 of of IN cord-010092-uftc8inx 1201 6 mutations mutation NNS cord-010092-uftc8inx 1201 7 in in IN cord-010092-uftc8inx 1201 8 RHD RHD NNP cord-010092-uftc8inx 1201 9 exons exon NNS cord-010092-uftc8inx 1201 10 6 6 CD cord-010092-uftc8inx 1201 11 and and CC cord-010092-uftc8inx 1201 12 7 7 CD cord-010092-uftc8inx 1201 13 by by IN cord-010092-uftc8inx 1201 14 MSA MSA NNP cord-010092-uftc8inx 1201 15 showed show VBD cord-010092-uftc8inx 1201 16 that that IN cord-010092-uftc8inx 1201 17 inclusion inclusion NN cord-010092-uftc8inx 1201 18 of of IN cord-010092-uftc8inx 1201 19 whole whole JJ cord-010092-uftc8inx 1201 20 exon exon NN cord-010092-uftc8inx 1201 21 sequence sequence NN cord-010092-uftc8inx 1201 22 in in IN cord-010092-uftc8inx 1201 23 the the DT cord-010092-uftc8inx 1201 24 mature mature JJ cord-010092-uftc8inx 1201 25 transcript transcript NN cord-010092-uftc8inx 1201 26 is be VBZ cord-010092-uftc8inx 1201 27 significantly significantly RB cord-010092-uftc8inx 1201 28 reduced reduce VBN cord-010092-uftc8inx 1201 29 in in IN cord-010092-uftc8inx 1201 30 15/46 15/46 CD cord-010092-uftc8inx 1201 31 ( ( -LRB- cord-010092-uftc8inx 1201 32 32.6 32.6 CD cord-010092-uftc8inx 1201 33 % % NN cord-010092-uftc8inx 1201 34 ) ) -RRB- cord-010092-uftc8inx 1201 35 variants variant NNS cord-010092-uftc8inx 1201 36 , , , cord-010092-uftc8inx 1201 37 which which WDT cord-010092-uftc8inx 1201 38 correlates correlate VBZ cord-010092-uftc8inx 1201 39 well well RB cord-010092-uftc8inx 1201 40 with with IN cord-010092-uftc8inx 1201 41 the the DT cord-010092-uftc8inx 1201 42 QUEPASA QUEPASA NNP cord-010092-uftc8inx 1201 43 - - HYPH cord-010092-uftc8inx 1201 44 like like JJ cord-010092-uftc8inx 1201 45 prediction prediction NN cord-010092-uftc8inx 1201 46 ( ( -LRB- cord-010092-uftc8inx 1201 47 sensibility sensibility NN cord-010092-uftc8inx 1201 48 = = SYM cord-010092-uftc8inx 1201 49 0.93 0.93 CD cord-010092-uftc8inx 1201 50 , , , cord-010092-uftc8inx 1201 51 specificity specificity NN cord-010092-uftc8inx 1201 52 = = SYM cord-010092-uftc8inx 1201 53 0.94 0.94 CD cord-010092-uftc8inx 1201 54 ) ) -RRB- cord-010092-uftc8inx 1201 55 . . . cord-010092-uftc8inx 1202 1 Additionally additionally RB cord-010092-uftc8inx 1202 2 , , , cord-010092-uftc8inx 1202 3 while while IN cord-010092-uftc8inx 1202 4 normal normal JJ cord-010092-uftc8inx 1202 5 exon exon NN cord-010092-uftc8inx 1202 6 inclusion inclusion NN cord-010092-uftc8inx 1202 7 is be VBZ cord-010092-uftc8inx 1202 8 affected affect VBN cord-010092-uftc8inx 1202 9 by by IN cord-010092-uftc8inx 1203 1 c.1012C c.1012C NFP cord-010092-uftc8inx 1203 2 > > XX cord-010092-uftc8inx 1204 1 G g NN cord-010092-uftc8inx 1204 2 ( ( -LRB- cord-010092-uftc8inx 1204 3 weak weak JJ cord-010092-uftc8inx 1204 4 D d NN cord-010092-uftc8inx 1204 5 type type NN cord-010092-uftc8inx 1204 6 70 70 CD cord-010092-uftc8inx 1204 7 ) ) -RRB- cord-010092-uftc8inx 1205 1 , , , cord-010092-uftc8inx 1205 2 the the DT cord-010092-uftc8inx 1205 3 associated associated JJ cord-010092-uftc8inx 1205 4 Leu338Val Leu338Val NNP cord-010092-uftc8inx 1205 5 substitution substitution NN cord-010092-uftc8inx 1205 6 does do VBZ cord-010092-uftc8inx 1205 7 not not RB cord-010092-uftc8inx 1205 8 seem seem VB cord-010092-uftc8inx 1205 9 to to TO cord-010092-uftc8inx 1205 10 be be VB cord-010092-uftc8inx 1205 11 deleterious deleterious JJ cord-010092-uftc8inx 1205 12 to to IN cord-010092-uftc8inx 1205 13 the the DT cord-010092-uftc8inx 1205 14 protein protein NN cord-010092-uftc8inx 1205 15 . . . cord-010092-uftc8inx 1206 1 Summary Summary NNP cord-010092-uftc8inx 1206 2 / / SYM cord-010092-uftc8inx 1206 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 1206 4 : : : cord-010092-uftc8inx 1207 1 On on IN cord-010092-uftc8inx 1207 2 the the DT cord-010092-uftc8inx 1207 3 basis basis NN cord-010092-uftc8inx 1207 4 of of IN cord-010092-uftc8inx 1207 5 our -PRON- PRP$ cord-010092-uftc8inx 1207 6 functional functional JJ cord-010092-uftc8inx 1207 7 data datum NNS cord-010092-uftc8inx 1207 8 , , , cord-010092-uftc8inx 1207 9 this this DT cord-010092-uftc8inx 1207 10 work work NN cord-010092-uftc8inx 1207 11 shows show VBZ cord-010092-uftc8inx 1207 12 that that IN cord-010092-uftc8inx 1207 13 splicing splice VBG cord-010092-uftc8inx 1207 14 disruption disruption NN cord-010092-uftc8inx 1207 15 in in IN cord-010092-uftc8inx 1207 16 the the DT cord-010092-uftc8inx 1207 17 presence presence NN cord-010092-uftc8inx 1207 18 of of IN cord-010092-uftc8inx 1207 19 RHD RHD NNP cord-010092-uftc8inx 1207 20 variants variant NNS cord-010092-uftc8inx 1207 21 is be VBZ cord-010092-uftc8inx 1207 22 a a DT cord-010092-uftc8inx 1207 23 common common JJ cord-010092-uftc8inx 1207 24 and and CC cord-010092-uftc8inx 1207 25 general general JJ cord-010092-uftc8inx 1207 26 mechanism mechanism NN cord-010092-uftc8inx 1207 27 that that WDT cord-010092-uftc8inx 1207 28 may may MD cord-010092-uftc8inx 1207 29 act act VB cord-010092-uftc8inx 1207 30 independently independently RB cord-010092-uftc8inx 1207 31 or or CC cord-010092-uftc8inx 1207 32 synergistically synergistically RB cord-010092-uftc8inx 1207 33 with with IN cord-010092-uftc8inx 1207 34 alteration alteration NN cord-010092-uftc8inx 1207 35 of of IN cord-010092-uftc8inx 1207 36 protein protein NN cord-010092-uftc8inx 1207 37 structure structure NN cord-010092-uftc8inx 1207 38 through through IN cord-010092-uftc8inx 1207 39 amino amino NN cord-010092-uftc8inx 1207 40 acid acid NN cord-010092-uftc8inx 1207 41 substitutions substitution NNS cord-010092-uftc8inx 1207 42 , , , cord-010092-uftc8inx 1207 43 resulting result VBG cord-010092-uftc8inx 1207 44 in in IN cord-010092-uftc8inx 1207 45 a a DT cord-010092-uftc8inx 1207 46 weak weak JJ cord-010092-uftc8inx 1207 47 D d NN cord-010092-uftc8inx 1207 48 phenotype phenotype NN cord-010092-uftc8inx 1207 49 . . . cord-010092-uftc8inx 1208 1 It -PRON- PRP cord-010092-uftc8inx 1208 2 also also RB cord-010092-uftc8inx 1208 3 illustrates illustrate VBZ cord-010092-uftc8inx 1208 4 the the DT cord-010092-uftc8inx 1208 5 potency potency NN cord-010092-uftc8inx 1208 6 of of IN cord-010092-uftc8inx 1208 7 combining combine VBG cord-010092-uftc8inx 1208 8 functional functional JJ cord-010092-uftc8inx 1208 9 tests test NNS cord-010092-uftc8inx 1208 10 and and CC cord-010092-uftc8inx 1208 11 in in IN cord-010092-uftc8inx 1208 12 silico silico NN cord-010092-uftc8inx 1208 13 tools tool NNS cord-010092-uftc8inx 1208 14 towards towards IN cord-010092-uftc8inx 1208 15 the the DT cord-010092-uftc8inx 1208 16 phenotypic phenotypic JJ cord-010092-uftc8inx 1208 17 / / SYM cord-010092-uftc8inx 1208 18 clinical clinical JJ cord-010092-uftc8inx 1208 19 interpretation interpretation NN cord-010092-uftc8inx 1208 20 of of IN cord-010092-uftc8inx 1208 21 rare rare JJ cord-010092-uftc8inx 1208 22 variants variant NNS cord-010092-uftc8inx 1208 23 . . . cord-010092-uftc8inx 1209 1 Background background NN cord-010092-uftc8inx 1209 2 / / SYM cord-010092-uftc8inx 1209 3 Aims aim VBZ cord-010092-uftc8inx 1209 4 : : : cord-010092-uftc8inx 1210 1 Monetary monetary JJ cord-010092-uftc8inx 1210 2 and and CC cord-010092-uftc8inx 1210 3 non non JJ cord-010092-uftc8inx 1210 4 - - JJ cord-010092-uftc8inx 1210 5 monetary monetary JJ cord-010092-uftc8inx 1210 6 incentives incentive NNS cord-010092-uftc8inx 1210 7 may may MD cord-010092-uftc8inx 1210 8 support support VB cord-010092-uftc8inx 1210 9 blood blood NN cord-010092-uftc8inx 1210 10 services service NNS cord-010092-uftc8inx 1210 11 in in IN cord-010092-uftc8inx 1210 12 recruiting recruit VBG cord-010092-uftc8inx 1210 13 blood blood NN cord-010092-uftc8inx 1210 14 donors donor NNS cord-010092-uftc8inx 1210 15 but but CC cord-010092-uftc8inx 1210 16 have have VBP cord-010092-uftc8inx 1210 17 also also RB cord-010092-uftc8inx 1210 18 been be VBN cord-010092-uftc8inx 1210 19 criticized criticize VBN cord-010092-uftc8inx 1210 20 for for IN cord-010092-uftc8inx 1210 21 violating violate VBG cord-010092-uftc8inx 1210 22 ethical ethical JJ cord-010092-uftc8inx 1210 23 principles principle NNS cord-010092-uftc8inx 1210 24 and and CC cord-010092-uftc8inx 1210 25 threatening threaten VBG cord-010092-uftc8inx 1210 26 blood blood NN cord-010092-uftc8inx 1210 27 safety safety NN cord-010092-uftc8inx 1210 28 by by IN cord-010092-uftc8inx 1210 29 attracting attract VBG cord-010092-uftc8inx 1210 30 donors donor NNS cord-010092-uftc8inx 1210 31 with with IN cord-010092-uftc8inx 1210 32 a a DT cord-010092-uftc8inx 1210 33 high high JJ cord-010092-uftc8inx 1210 34 risk risk NN cord-010092-uftc8inx 1210 35 for for IN cord-010092-uftc8inx 1210 36 infectious infectious JJ cord-010092-uftc8inx 1210 37 diseases disease NNS cord-010092-uftc8inx 1210 38 . . . cord-010092-uftc8inx 1211 1 Although although IN cord-010092-uftc8inx 1211 2 incentives incentive NNS cord-010092-uftc8inx 1211 3 for for IN cord-010092-uftc8inx 1211 4 blood blood NN cord-010092-uftc8inx 1211 5 donors donor NNS cord-010092-uftc8inx 1211 6 have have VBP cord-010092-uftc8inx 1211 7 been be VBN cord-010092-uftc8inx 1211 8 discussed discuss VBN cord-010092-uftc8inx 1211 9 extensively extensively RB cord-010092-uftc8inx 1211 10 over over IN cord-010092-uftc8inx 1211 11 the the DT cord-010092-uftc8inx 1211 12 past past JJ cord-010092-uftc8inx 1211 13 decades decade NNS cord-010092-uftc8inx 1211 14 , , , cord-010092-uftc8inx 1211 15 empirical empirical JJ cord-010092-uftc8inx 1211 16 research research NN cord-010092-uftc8inx 1211 17 on on IN cord-010092-uftc8inx 1211 18 this this DT cord-010092-uftc8inx 1211 19 topic topic NN cord-010092-uftc8inx 1211 20 remains remain VBZ cord-010092-uftc8inx 1211 21 limited limited JJ cord-010092-uftc8inx 1211 22 . . . cord-010092-uftc8inx 1212 1 The the DT cord-010092-uftc8inx 1212 2 aim aim NN cord-010092-uftc8inx 1212 3 of of IN cord-010092-uftc8inx 1212 4 this this DT cord-010092-uftc8inx 1212 5 study study NN cord-010092-uftc8inx 1212 6 was be VBD cord-010092-uftc8inx 1212 7 to to TO cord-010092-uftc8inx 1212 8 describe describe VB cord-010092-uftc8inx 1212 9 attitudes attitude NNS cord-010092-uftc8inx 1212 10 towards towards IN cord-010092-uftc8inx 1212 11 incentives incentive NNS cord-010092-uftc8inx 1212 12 for for IN cord-010092-uftc8inx 1212 13 blood blood NN cord-010092-uftc8inx 1212 14 donors donor NNS cord-010092-uftc8inx 1212 15 in in IN cord-010092-uftc8inx 1212 16 Europe Europe NNP cord-010092-uftc8inx 1212 17 and and CC cord-010092-uftc8inx 1212 18 show show VB cord-010092-uftc8inx 1212 19 donor donor NN cord-010092-uftc8inx 1212 20 return return NN cord-010092-uftc8inx 1212 21 rates rate NNS cord-010092-uftc8inx 1212 22 of of IN cord-010092-uftc8inx 1212 23 compensated compensated JJ cord-010092-uftc8inx 1212 24 and and CC cord-010092-uftc8inx 1212 25 non non JJ cord-010092-uftc8inx 1212 26 - - JJ cord-010092-uftc8inx 1212 27 compensated compensated JJ cord-010092-uftc8inx 1212 28 blood blood NN cord-010092-uftc8inx 1212 29 donors donor NNS cord-010092-uftc8inx 1212 30 in in IN cord-010092-uftc8inx 1212 31 South South NNP cord-010092-uftc8inx 1212 32 - - HYPH cord-010092-uftc8inx 1212 33 West West NNP cord-010092-uftc8inx 1212 34 Germany Germany NNP cord-010092-uftc8inx 1212 35 . . . cord-010092-uftc8inx 1213 1 Methods method NNS cord-010092-uftc8inx 1213 2 : : : cord-010092-uftc8inx 1213 3 First first RB cord-010092-uftc8inx 1213 4 , , , cord-010092-uftc8inx 1213 5 we -PRON- PRP cord-010092-uftc8inx 1213 6 present present VBP cord-010092-uftc8inx 1213 7 results result NNS cord-010092-uftc8inx 1213 8 of of IN cord-010092-uftc8inx 1213 9 a a DT cord-010092-uftc8inx 1213 10 secondary secondary JJ cord-010092-uftc8inx 1213 11 analysis analysis NN cord-010092-uftc8inx 1213 12 of of IN cord-010092-uftc8inx 1213 13 the the DT cord-010092-uftc8inx 1213 14 eurobarometer eurobarometer NN cord-010092-uftc8inx 1213 15 , , , cord-010092-uftc8inx 1213 16 a a DT cord-010092-uftc8inx 1213 17 nationally nationally RB cord-010092-uftc8inx 1213 18 representative representative JJ cord-010092-uftc8inx 1213 19 survey survey NN cord-010092-uftc8inx 1213 20 in in IN cord-010092-uftc8inx 1213 21 all all DT cord-010092-uftc8inx 1213 22 member member NN cord-010092-uftc8inx 1213 23 states state NNS cord-010092-uftc8inx 1213 24 of of IN cord-010092-uftc8inx 1213 25 the the DT cord-010092-uftc8inx 1213 26 European European NNP cord-010092-uftc8inx 1213 27 Union Union NNP cord-010092-uftc8inx 1213 28 . . . cord-010092-uftc8inx 1214 1 In in IN cord-010092-uftc8inx 1214 2 2014 2014 CD cord-010092-uftc8inx 1214 3 , , , cord-010092-uftc8inx 1214 4 participants participant NNS cord-010092-uftc8inx 1214 5 were be VBD cord-010092-uftc8inx 1214 6 asked ask VBN cord-010092-uftc8inx 1214 7 to to TO cord-010092-uftc8inx 1214 8 evaluate evaluate VB cord-010092-uftc8inx 1214 9 eight eight CD cord-010092-uftc8inx 1214 10 potential potential JJ cord-010092-uftc8inx 1214 11 incentives incentive NNS cord-010092-uftc8inx 1214 12 for for IN cord-010092-uftc8inx 1214 13 blood blood NN cord-010092-uftc8inx 1214 14 donations donation NNS cord-010092-uftc8inx 1214 15 as as IN cord-010092-uftc8inx 1214 16 acceptable acceptable JJ cord-010092-uftc8inx 1214 17 or or CC cord-010092-uftc8inx 1214 18 unacceptable unacceptable JJ cord-010092-uftc8inx 1214 19 . . . cord-010092-uftc8inx 1215 1 These these DT cord-010092-uftc8inx 1215 2 incentives incentive NNS cord-010092-uftc8inx 1215 3 were be VBD cord-010092-uftc8inx 1215 4 refreshments refreshment NNS cord-010092-uftc8inx 1215 5 ( ( -LRB- cord-010092-uftc8inx 1215 6 e.g. e.g. JJ cord-010092-uftc8inx 1215 7 coffee coffee NN cord-010092-uftc8inx 1215 8 ) ) -RRB- cord-010092-uftc8inx 1215 9 , , , cord-010092-uftc8inx 1215 10 physical physical JJ cord-010092-uftc8inx 1215 11 check check NN cord-010092-uftc8inx 1215 12 - - HYPH cord-010092-uftc8inx 1215 13 ups up NNS cord-010092-uftc8inx 1215 14 ( ( -LRB- cord-010092-uftc8inx 1215 15 e.g. e.g. RB cord-010092-uftc8inx 1215 16 blood blood NN cord-010092-uftc8inx 1215 17 pressure pressure NN cord-010092-uftc8inx 1215 18 ) ) -RRB- cord-010092-uftc8inx 1215 19 , , , cord-010092-uftc8inx 1215 20 free free JJ cord-010092-uftc8inx 1215 21 ( ( -LRB- cord-010092-uftc8inx 1215 22 testing test VBG cord-010092-uftc8inx 1215 23 ) ) -RRB- cord-010092-uftc8inx 1215 24 laboratory laboratory NN cord-010092-uftc8inx 1215 25 parameters parameter NNS cord-010092-uftc8inx 1215 26 , , , cord-010092-uftc8inx 1215 27 free free JJ cord-010092-uftc8inx 1215 28 medical medical JJ cord-010092-uftc8inx 1215 29 treatment treatment NN cord-010092-uftc8inx 1215 30 , , , cord-010092-uftc8inx 1215 31 complimentary complimentary JJ cord-010092-uftc8inx 1215 32 items item NNS cord-010092-uftc8inx 1215 33 ( ( -LRB- cord-010092-uftc8inx 1215 34 e.g. e.g. RB cord-010092-uftc8inx 1215 35 first first JJ cord-010092-uftc8inx 1215 36 aid aid NN cord-010092-uftc8inx 1215 37 kits kit NNS cord-010092-uftc8inx 1215 38 ) ) -RRB- cord-010092-uftc8inx 1215 39 , , , cord-010092-uftc8inx 1215 40 monetary monetary JJ cord-010092-uftc8inx 1215 41 travel travel NN cord-010092-uftc8inx 1215 42 reimbursements reimbursement NNS cord-010092-uftc8inx 1215 43 , , , cord-010092-uftc8inx 1215 44 additional additional JJ cord-010092-uftc8inx 1215 45 cash cash NN cord-010092-uftc8inx 1215 46 reimbursements reimbursement NNS cord-010092-uftc8inx 1215 47 , , , cord-010092-uftc8inx 1215 48 and and CC cord-010092-uftc8inx 1215 49 release release NN cord-010092-uftc8inx 1215 50 from from IN cord-010092-uftc8inx 1215 51 work work NN cord-010092-uftc8inx 1215 52 . . . cord-010092-uftc8inx 1216 1 Second second RB cord-010092-uftc8inx 1216 2 , , , cord-010092-uftc8inx 1216 3 we -PRON- PRP cord-010092-uftc8inx 1216 4 conducted conduct VBD cord-010092-uftc8inx 1216 5 a a DT cord-010092-uftc8inx 1216 6 retrospective retrospective JJ cord-010092-uftc8inx 1216 7 analysis analysis NN cord-010092-uftc8inx 1216 8 of of IN cord-010092-uftc8inx 1216 9 donor donor NN cord-010092-uftc8inx 1216 10 return return NN cord-010092-uftc8inx 1216 11 patterns pattern NNS cord-010092-uftc8inx 1216 12 of of IN cord-010092-uftc8inx 1216 13 6.210 6.210 CD cord-010092-uftc8inx 1216 14 compensated compensate VBN cord-010092-uftc8inx 1216 15 and and CC cord-010092-uftc8inx 1216 16 68.205 68.205 CD cord-010092-uftc8inx 1216 17 non non JJ cord-010092-uftc8inx 1216 18 - - JJ cord-010092-uftc8inx 1216 19 compensated compensate VBN cord-010092-uftc8inx 1216 20 donors donor NNS cord-010092-uftc8inx 1216 21 who who WP cord-010092-uftc8inx 1216 22 started start VBD cord-010092-uftc8inx 1216 23 donating donate VBG cord-010092-uftc8inx 1216 24 blood blood NN cord-010092-uftc8inx 1216 25 at at IN cord-010092-uftc8inx 1216 26 mobile mobile NN cord-010092-uftc8inx 1216 27 and and CC cord-010092-uftc8inx 1216 28 fixed fixed JJ cord-010092-uftc8inx 1216 29 donation donation NN cord-010092-uftc8inx 1216 30 sites site NNS cord-010092-uftc8inx 1216 31 . . . cord-010092-uftc8inx 1217 1 Compensated compensate VBN cord-010092-uftc8inx 1217 2 donors donor NNS cord-010092-uftc8inx 1217 3 received receive VBD cord-010092-uftc8inx 1217 4 either either CC cord-010092-uftc8inx 1217 5 25 25 CD cord-010092-uftc8inx 1217 6 EUR EUR NNP cord-010092-uftc8inx 1217 7 as as IN cord-010092-uftc8inx 1217 8 a a DT cord-010092-uftc8inx 1217 9 regular regular JJ cord-010092-uftc8inx 1217 10 reimbursement reimbursement NN cord-010092-uftc8inx 1217 11 for for IN cord-010092-uftc8inx 1217 12 their -PRON- PRP$ cord-010092-uftc8inx 1217 13 expenses expense NNS cord-010092-uftc8inx 1217 14 ( ( -LRB- cord-010092-uftc8inx 1217 15 at at IN cord-010092-uftc8inx 1217 16 a a DT cord-010092-uftc8inx 1217 17 fixed fix VBN cord-010092-uftc8inx 1217 18 donation donation NN cord-010092-uftc8inx 1217 19 site site NN cord-010092-uftc8inx 1217 20 ) ) -RRB- cord-010092-uftc8inx 1217 21 , , , cord-010092-uftc8inx 1217 22 in in IN cord-010092-uftc8inx 1217 23 accordance accordance NN cord-010092-uftc8inx 1217 24 with with IN cord-010092-uftc8inx 1217 25 the the DT cord-010092-uftc8inx 1217 26 German german JJ cord-010092-uftc8inx 1217 27 transfusion transfusion NN cord-010092-uftc8inx 1217 28 law law NN cord-010092-uftc8inx 1217 29 , , , cord-010092-uftc8inx 1217 30 or or CC cord-010092-uftc8inx 1217 31 a a DT cord-010092-uftc8inx 1217 32 singular singular JJ cord-010092-uftc8inx 1217 33 free free JJ cord-010092-uftc8inx 1217 34 entrance entrance NN cord-010092-uftc8inx 1217 35 for for IN cord-010092-uftc8inx 1217 36 an an DT cord-010092-uftc8inx 1217 37 amusement amusement NN cord-010092-uftc8inx 1217 38 park park NN cord-010092-uftc8inx 1217 39 ( ( -LRB- cord-010092-uftc8inx 1217 40 at at IN cord-010092-uftc8inx 1217 41 a a DT cord-010092-uftc8inx 1217 42 mobile mobile JJ cord-010092-uftc8inx 1217 43 donation donation NN cord-010092-uftc8inx 1217 44 site site NN cord-010092-uftc8inx 1217 45 ) ) -RRB- cord-010092-uftc8inx 1217 46 . . . cord-010092-uftc8inx 1218 1 These these DT cord-010092-uftc8inx 1218 2 compensated compensate VBN cord-010092-uftc8inx 1218 3 donors donor NNS cord-010092-uftc8inx 1218 4 were be VBD cord-010092-uftc8inx 1218 5 compared compare VBN cord-010092-uftc8inx 1218 6 with with IN cord-010092-uftc8inx 1218 7 noncompensated noncompensated JJ cord-010092-uftc8inx 1218 8 donors donor NNS cord-010092-uftc8inx 1218 9 who who WP cord-010092-uftc8inx 1218 10 started start VBD cord-010092-uftc8inx 1218 11 either either CC cord-010092-uftc8inx 1218 12 at at IN cord-010092-uftc8inx 1218 13 a a DT cord-010092-uftc8inx 1218 14 fixed fixed JJ cord-010092-uftc8inx 1218 15 or or CC cord-010092-uftc8inx 1218 16 mobile mobile JJ cord-010092-uftc8inx 1218 17 donation donation NN cord-010092-uftc8inx 1218 18 site site NN cord-010092-uftc8inx 1218 19 . . . cord-010092-uftc8inx 1219 1 Chisquare Chisquare NNP cord-010092-uftc8inx 1219 2 statistics statistic NNS cord-010092-uftc8inx 1219 3 were be VBD cord-010092-uftc8inx 1219 4 used use VBN cord-010092-uftc8inx 1219 5 to to TO cord-010092-uftc8inx 1219 6 test test VB cord-010092-uftc8inx 1219 7 for for IN cord-010092-uftc8inx 1219 8 differences difference NNS cord-010092-uftc8inx 1219 9 in in IN cord-010092-uftc8inx 1219 10 regular regular JJ cord-010092-uftc8inx 1219 11 donor donor NN cord-010092-uftc8inx 1219 12 status status NN cord-010092-uftc8inx 1219 13 after after IN cord-010092-uftc8inx 1219 14 24 24 CD cord-010092-uftc8inx 1219 15 , , , cord-010092-uftc8inx 1219 16 36 36 CD cord-010092-uftc8inx 1219 17 , , , cord-010092-uftc8inx 1219 18 48 48 CD cord-010092-uftc8inx 1219 19 and and CC cord-010092-uftc8inx 1219 20 72 72 CD cord-010092-uftc8inx 1219 21 months month NNS cord-010092-uftc8inx 1219 22 between between IN cord-010092-uftc8inx 1219 23 compensated compensated JJ cord-010092-uftc8inx 1219 24 and and CC cord-010092-uftc8inx 1219 25 non non JJ cord-010092-uftc8inx 1219 26 - - JJ cord-010092-uftc8inx 1219 27 compensated compensated JJ cord-010092-uftc8inx 1219 28 first first JJ cord-010092-uftc8inx 1219 29 - - HYPH cord-010092-uftc8inx 1219 30 time time NN cord-010092-uftc8inx 1219 31 donors donor NNS cord-010092-uftc8inx 1219 32 . . . cord-010092-uftc8inx 1220 1 Results result NNS cord-010092-uftc8inx 1220 2 : : : cord-010092-uftc8inx 1221 1 Among among IN cord-010092-uftc8inx 1221 2 German german JJ cord-010092-uftc8inx 1221 3 participants participant NNS cord-010092-uftc8inx 1221 4 of of IN cord-010092-uftc8inx 1221 5 the the DT cord-010092-uftc8inx 1221 6 eurobarometer eurobarometer NN cord-010092-uftc8inx 1221 7 , , , cord-010092-uftc8inx 1221 8 physical physical JJ cord-010092-uftc8inx 1221 9 check check NN cord-010092-uftc8inx 1221 10 - - HYPH cord-010092-uftc8inx 1221 11 ups up NNS cord-010092-uftc8inx 1221 12 ( ( -LRB- cord-010092-uftc8inx 1221 13 51.9 51.9 CD cord-010092-uftc8inx 1221 14 % % NN cord-010092-uftc8inx 1221 15 ) ) -RRB- cord-010092-uftc8inx 1221 16 , , , cord-010092-uftc8inx 1221 17 refreshments refreshment NNS cord-010092-uftc8inx 1221 18 ( ( -LRB- cord-010092-uftc8inx 1221 19 50.0 50.0 CD cord-010092-uftc8inx 1221 20 % % NN cord-010092-uftc8inx 1221 21 ) ) -RRB- cord-010092-uftc8inx 1221 22 and and CC cord-010092-uftc8inx 1221 23 free free JJ cord-010092-uftc8inx 1221 24 ( ( -LRB- cord-010092-uftc8inx 1221 25 testing testing NN cord-010092-uftc8inx 1221 26 ) ) -RRB- cord-010092-uftc8inx 1221 27 laboratory laboratory NN cord-010092-uftc8inx 1221 28 parameters parameter NNS cord-010092-uftc8inx 1221 29 ( ( -LRB- cord-010092-uftc8inx 1221 30 38.3 38.3 CD cord-010092-uftc8inx 1221 31 % % NN cord-010092-uftc8inx 1221 32 ) ) -RRB- cord-010092-uftc8inx 1221 33 showed show VBD cord-010092-uftc8inx 1221 34 the the DT cord-010092-uftc8inx 1221 35 highest high JJS cord-010092-uftc8inx 1221 36 acceptance acceptance NN cord-010092-uftc8inx 1221 37 as as IN cord-010092-uftc8inx 1221 38 an an DT cord-010092-uftc8inx 1221 39 incentive incentive NN cord-010092-uftc8inx 1221 40 for for IN cord-010092-uftc8inx 1221 41 blood blood NN cord-010092-uftc8inx 1221 42 donors donor NNS cord-010092-uftc8inx 1221 43 . . . cord-010092-uftc8inx 1222 1 Travel travel NN cord-010092-uftc8inx 1222 2 reimbursements reimbursement NNS cord-010092-uftc8inx 1222 3 and and CC cord-010092-uftc8inx 1222 4 free free JJ cord-010092-uftc8inx 1222 5 medical medical JJ cord-010092-uftc8inx 1222 6 treatment treatment NN cord-010092-uftc8inx 1222 7 were be VBD cord-010092-uftc8inx 1222 8 rated rate VBN cord-010092-uftc8inx 1222 9 as as IN cord-010092-uftc8inx 1222 10 acceptable acceptable JJ cord-010092-uftc8inx 1222 11 by by IN cord-010092-uftc8inx 1222 12 28.6 28.6 CD cord-010092-uftc8inx 1222 13 % % NN cord-010092-uftc8inx 1222 14 and and CC cord-010092-uftc8inx 1222 15 25.3 25.3 CD cord-010092-uftc8inx 1222 16 % % NN cord-010092-uftc8inx 1222 17 , , , cord-010092-uftc8inx 1222 18 respectively respectively RB cord-010092-uftc8inx 1222 19 . . . cord-010092-uftc8inx 1223 1 The the DT cord-010092-uftc8inx 1223 2 lowest low JJS cord-010092-uftc8inx 1223 3 acceptance acceptance NN cord-010092-uftc8inx 1223 4 was be VBD cord-010092-uftc8inx 1223 5 for for IN cord-010092-uftc8inx 1223 6 release release NN cord-010092-uftc8inx 1223 7 from from IN cord-010092-uftc8inx 1223 8 work work NN cord-010092-uftc8inx 1223 9 ( ( -LRB- cord-010092-uftc8inx 1223 10 17.8 17.8 CD cord-010092-uftc8inx 1223 11 % % NN cord-010092-uftc8inx 1223 12 ) ) -RRB- cord-010092-uftc8inx 1223 13 , , , cord-010092-uftc8inx 1223 14 complementary complementary JJ cord-010092-uftc8inx 1223 15 items item NNS cord-010092-uftc8inx 1223 16 ( ( -LRB- cord-010092-uftc8inx 1223 17 13.9 13.9 CD cord-010092-uftc8inx 1223 18 % % NN cord-010092-uftc8inx 1223 19 ) ) -RRB- cord-010092-uftc8inx 1223 20 and and CC cord-010092-uftc8inx 1223 21 additional additional JJ cord-010092-uftc8inx 1223 22 cash cash NN cord-010092-uftc8inx 1223 23 reimbursement reimbursement NN cord-010092-uftc8inx 1223 24 ( ( -LRB- cord-010092-uftc8inx 1223 25 11.8 11.8 CD cord-010092-uftc8inx 1223 26 % % NN cord-010092-uftc8inx 1223 27 ) ) -RRB- cord-010092-uftc8inx 1223 28 . . . cord-010092-uftc8inx 1224 1 Interestingly interestingly RB cord-010092-uftc8inx 1224 2 , , , cord-010092-uftc8inx 1224 3 the the DT cord-010092-uftc8inx 1224 4 acceptance acceptance NN cord-010092-uftc8inx 1224 5 of of IN cord-010092-uftc8inx 1224 6 potential potential JJ cord-010092-uftc8inx 1224 7 incentives incentive NNS cord-010092-uftc8inx 1224 8 varies vary VBZ cord-010092-uftc8inx 1224 9 considerably considerably RB cord-010092-uftc8inx 1224 10 across across IN cord-010092-uftc8inx 1224 11 Europe Europe NNP cord-010092-uftc8inx 1224 12 . . . cord-010092-uftc8inx 1225 1 In in IN cord-010092-uftc8inx 1225 2 South South NNP cord-010092-uftc8inx 1225 3 - - HYPH cord-010092-uftc8inx 1225 4 West West NNP cord-010092-uftc8inx 1225 5 Germany Germany NNP cord-010092-uftc8inx 1225 6 , , , cord-010092-uftc8inx 1225 7 donor donor NN cord-010092-uftc8inx 1225 8 return return NN cord-010092-uftc8inx 1225 9 of of IN cord-010092-uftc8inx 1225 10 first first JJ cord-010092-uftc8inx 1225 11 - - HYPH cord-010092-uftc8inx 1225 12 time time NN cord-010092-uftc8inx 1225 13 donors donor NNS cord-010092-uftc8inx 1225 14 differed differ VBD cord-010092-uftc8inx 1225 15 significantly significantly RB cord-010092-uftc8inx 1225 16 by by IN cord-010092-uftc8inx 1225 17 type type NN cord-010092-uftc8inx 1225 18 of of IN cord-010092-uftc8inx 1225 19 compensation compensation NN cord-010092-uftc8inx 1225 20 . . . cord-010092-uftc8inx 1226 1 Among among IN cord-010092-uftc8inx 1226 2 compensated compensate VBN cord-010092-uftc8inx 1226 3 first first JJ cord-010092-uftc8inx 1226 4 - - HYPH cord-010092-uftc8inx 1226 5 time time NN cord-010092-uftc8inx 1226 6 donors donor NNS cord-010092-uftc8inx 1226 7 , , , cord-010092-uftc8inx 1226 8 who who WP cord-010092-uftc8inx 1226 9 received receive VBD cord-010092-uftc8inx 1226 10 25 25 CD cord-010092-uftc8inx 1226 11 EUR EUR NNP cord-010092-uftc8inx 1226 12 as as IN cord-010092-uftc8inx 1226 13 a a DT cord-010092-uftc8inx 1226 14 monetary monetary JJ cord-010092-uftc8inx 1226 15 reimbursement reimbursement NN cord-010092-uftc8inx 1226 16 , , , cord-010092-uftc8inx 1226 17 the the DT cord-010092-uftc8inx 1226 18 proportion proportion NN cord-010092-uftc8inx 1226 19 of of IN cord-010092-uftc8inx 1226 20 regular regular JJ cord-010092-uftc8inx 1226 21 donors donor NNS cord-010092-uftc8inx 1226 22 after after IN cord-010092-uftc8inx 1226 23 48 48 CD cord-010092-uftc8inx 1226 24 months month NNS cord-010092-uftc8inx 1226 25 ( ( -LRB- cord-010092-uftc8inx 1226 26 19.9 19.9 CD cord-010092-uftc8inx 1226 27 % % NN cord-010092-uftc8inx 1226 28 ) ) -RRB- cord-010092-uftc8inx 1226 29 was be VBD cord-010092-uftc8inx 1226 30 significantly significantly RB cord-010092-uftc8inx 1226 31 higher high JJR cord-010092-uftc8inx 1226 32 than than IN cord-010092-uftc8inx 1226 33 among among IN cord-010092-uftc8inx 1226 34 comparable comparable JJ cord-010092-uftc8inx 1226 35 non non JJ cord-010092-uftc8inx 1226 36 - - JJ cord-010092-uftc8inx 1226 37 compensated compensate VBN cord-010092-uftc8inx 1226 38 donors donor NNS cord-010092-uftc8inx 1226 39 ( ( -LRB- cord-010092-uftc8inx 1226 40 9.2 9.2 CD cord-010092-uftc8inx 1226 41 % % NN cord-010092-uftc8inx 1226 42 ) ) -RRB- cord-010092-uftc8inx 1226 43 . . . cord-010092-uftc8inx 1227 1 However however RB cord-010092-uftc8inx 1227 2 , , , cord-010092-uftc8inx 1227 3 a a DT cord-010092-uftc8inx 1227 4 non non JJ cord-010092-uftc8inx 1227 5 - - JJ cord-010092-uftc8inx 1227 6 monetary monetary JJ cord-010092-uftc8inx 1227 7 compensation compensation NN cord-010092-uftc8inx 1227 8 ( ( -LRB- cord-010092-uftc8inx 1227 9 free free JJ cord-010092-uftc8inx 1227 10 entrance entrance NN cord-010092-uftc8inx 1227 11 ) ) -RRB- cord-010092-uftc8inx 1227 12 did do VBD cord-010092-uftc8inx 1227 13 not not RB cord-010092-uftc8inx 1227 14 increase increase VB cord-010092-uftc8inx 1227 15 donor donor NN cord-010092-uftc8inx 1227 16 return return NN cord-010092-uftc8inx 1227 17 rates rate NNS cord-010092-uftc8inx 1227 18 . . . cord-010092-uftc8inx 1228 1 Conclusion conclusion NN cord-010092-uftc8inx 1228 2 : : : cord-010092-uftc8inx 1229 1 The the DT cord-010092-uftc8inx 1229 2 eurobarometer eurobarometer NN cord-010092-uftc8inx 1229 3 survey survey NN cord-010092-uftc8inx 1229 4 indicates indicate VBZ cord-010092-uftc8inx 1229 5 that that IN cord-010092-uftc8inx 1229 6 in in IN cord-010092-uftc8inx 1229 7 most most JJS cord-010092-uftc8inx 1229 8 European european JJ cord-010092-uftc8inx 1229 9 countries country NNS cord-010092-uftc8inx 1229 10 monetary monetary JJ cord-010092-uftc8inx 1229 11 incentives incentive NNS cord-010092-uftc8inx 1229 12 are be VBP cord-010092-uftc8inx 1229 13 only only RB cord-010092-uftc8inx 1229 14 accepted accept VBN cord-010092-uftc8inx 1229 15 by by IN cord-010092-uftc8inx 1229 16 a a DT cord-010092-uftc8inx 1229 17 small small JJ cord-010092-uftc8inx 1229 18 minority minority NN cord-010092-uftc8inx 1229 19 . . . cord-010092-uftc8inx 1230 1 Refreshments refreshment NNS cord-010092-uftc8inx 1230 2 , , , cord-010092-uftc8inx 1230 3 checkups checkup NNS cord-010092-uftc8inx 1230 4 , , , cord-010092-uftc8inx 1230 5 free free JJ cord-010092-uftc8inx 1230 6 ( ( -LRB- cord-010092-uftc8inx 1230 7 testing testing NN cord-010092-uftc8inx 1230 8 ) ) -RRB- cord-010092-uftc8inx 1230 9 laboratory laboratory NN cord-010092-uftc8inx 1230 10 parameters parameter NNS cord-010092-uftc8inx 1230 11 and and CC cord-010092-uftc8inx 1230 12 free free JJ cord-010092-uftc8inx 1230 13 medical medical JJ cord-010092-uftc8inx 1230 14 treatment treatment NN cord-010092-uftc8inx 1230 15 were be VBD cord-010092-uftc8inx 1230 16 most most RBS cord-010092-uftc8inx 1230 17 popular popular JJ cord-010092-uftc8inx 1230 18 as as IN cord-010092-uftc8inx 1230 19 incentives incentive NNS cord-010092-uftc8inx 1230 20 for for IN cord-010092-uftc8inx 1230 21 blood blood NN cord-010092-uftc8inx 1230 22 donors donor NNS cord-010092-uftc8inx 1230 23 . . . cord-010092-uftc8inx 1231 1 However however RB cord-010092-uftc8inx 1231 2 , , , cord-010092-uftc8inx 1231 3 results result NNS cord-010092-uftc8inx 1231 4 of of IN cord-010092-uftc8inx 1231 5 our -PRON- PRP$ cord-010092-uftc8inx 1231 6 four four CD cord-010092-uftc8inx 1231 7 non non JJ cord-010092-uftc8inx 1231 8 - - JJ cord-010092-uftc8inx 1231 9 randomized randomized JJ cord-010092-uftc8inx 1231 10 donor donor NN cord-010092-uftc8inx 1231 11 samples sample NNS cord-010092-uftc8inx 1231 12 from from IN cord-010092-uftc8inx 1231 13 South South NNP cord-010092-uftc8inx 1231 14 - - HYPH cord-010092-uftc8inx 1231 15 West West NNP cord-010092-uftc8inx 1231 16 Germany Germany NNP cord-010092-uftc8inx 1231 17 suggest suggest VBP cord-010092-uftc8inx 1231 18 that that IN cord-010092-uftc8inx 1231 19 monetary monetary JJ cord-010092-uftc8inx 1231 20 compensation compensation NN cord-010092-uftc8inx 1231 21 may may MD cord-010092-uftc8inx 1231 22 increase increase VB cord-010092-uftc8inx 1231 23 the the DT cord-010092-uftc8inx 1231 24 likelihood likelihood NN cord-010092-uftc8inx 1231 25 of of IN cord-010092-uftc8inx 1231 26 donors donor NNS cord-010092-uftc8inx 1231 27 returning return VBG cord-010092-uftc8inx 1231 28 to to IN cord-010092-uftc8inx 1231 29 fixed fix VBN cord-010092-uftc8inx 1231 30 donation donation NN cord-010092-uftc8inx 1231 31 sites site NNS cord-010092-uftc8inx 1231 32 . . . cord-010092-uftc8inx 1232 1 Regular regular JJ cord-010092-uftc8inx 1232 2 monetary monetary JJ cord-010092-uftc8inx 1232 3 reward reward NN cord-010092-uftc8inx 1232 4 may may MD cord-010092-uftc8inx 1232 5 therefore therefore RB cord-010092-uftc8inx 1232 6 help help VB cord-010092-uftc8inx 1232 7 to to TO cord-010092-uftc8inx 1232 8 recruit recruit VB cord-010092-uftc8inx 1232 9 regular regular JJ cord-010092-uftc8inx 1232 10 donors donor NNS cord-010092-uftc8inx 1232 11 especially especially RB cord-010092-uftc8inx 1232 12 in in IN cord-010092-uftc8inx 1232 13 urban urban JJ cord-010092-uftc8inx 1232 14 settings setting NNS cord-010092-uftc8inx 1232 15 . . . cord-010092-uftc8inx 1233 1 Incidentally incidentally RB cord-010092-uftc8inx 1233 2 , , , cord-010092-uftc8inx 1233 3 non non JJ cord-010092-uftc8inx 1233 4 - - JJ cord-010092-uftc8inx 1233 5 monetary monetary JJ cord-010092-uftc8inx 1233 6 compensation compensation NN cord-010092-uftc8inx 1233 7 by by IN cord-010092-uftc8inx 1233 8 a a DT cord-010092-uftc8inx 1233 9 free free JJ cord-010092-uftc8inx 1233 10 entrance entrance NN cord-010092-uftc8inx 1233 11 , , , cord-010092-uftc8inx 1233 12 however however RB cord-010092-uftc8inx 1233 13 , , , cord-010092-uftc8inx 1233 14 may may MD cord-010092-uftc8inx 1233 15 not not RB cord-010092-uftc8inx 1233 16 affect affect VB cord-010092-uftc8inx 1233 17 donor donor NN cord-010092-uftc8inx 1233 18 return return NN cord-010092-uftc8inx 1233 19 . . . cord-010092-uftc8inx 1234 1 Background background NN cord-010092-uftc8inx 1234 2 : : : cord-010092-uftc8inx 1235 1 Previous previous JJ cord-010092-uftc8inx 1235 2 research research NN cord-010092-uftc8inx 1235 3 showed show VBD cord-010092-uftc8inx 1235 4 that that IN cord-010092-uftc8inx 1235 5 whole whole JJ cord-010092-uftc8inx 1235 6 blood blood NN cord-010092-uftc8inx 1235 7 ( ( -LRB- cord-010092-uftc8inx 1235 8 WB WB NNP cord-010092-uftc8inx 1235 9 ) ) -RRB- cord-010092-uftc8inx 1235 10 donors donor NNS cord-010092-uftc8inx 1235 11 that that WDT cord-010092-uftc8inx 1235 12 are be VBP cord-010092-uftc8inx 1235 13 temporarily temporarily RB cord-010092-uftc8inx 1235 14 deferred defer VBN cord-010092-uftc8inx 1235 15 on on IN cord-010092-uftc8inx 1235 16 - - HYPH cord-010092-uftc8inx 1235 17 site site NN cord-010092-uftc8inx 1235 18 are be VBP cord-010092-uftc8inx 1235 19 at at IN cord-010092-uftc8inx 1235 20 higher high JJR cord-010092-uftc8inx 1235 21 risk risk NN cord-010092-uftc8inx 1235 22 of of IN cord-010092-uftc8inx 1235 23 lapsing lapse VBG cord-010092-uftc8inx 1235 24 , , , cord-010092-uftc8inx 1235 25 yet yet CC cord-010092-uftc8inx 1235 26 very very RB cord-010092-uftc8inx 1235 27 little little JJ cord-010092-uftc8inx 1235 28 studies study NNS cord-010092-uftc8inx 1235 29 have have VBP cord-010092-uftc8inx 1235 30 focused focus VBN cord-010092-uftc8inx 1235 31 on on IN cord-010092-uftc8inx 1235 32 differentiating differentiate VBG cord-010092-uftc8inx 1235 33 the the DT cord-010092-uftc8inx 1235 34 effects effect NNS cord-010092-uftc8inx 1235 35 that that WDT cord-010092-uftc8inx 1235 36 different different JJ cord-010092-uftc8inx 1235 37 deferral deferral NN cord-010092-uftc8inx 1235 38 reasons reason NNS cord-010092-uftc8inx 1235 39 ( ( -LRB- cord-010092-uftc8inx 1235 40 e.g. e.g. RB cord-010092-uftc8inx 1235 41 , , , cord-010092-uftc8inx 1235 42 travel travel NN cord-010092-uftc8inx 1235 43 , , , cord-010092-uftc8inx 1235 44 hemoglobin hemoglobin NN cord-010092-uftc8inx 1235 45 [ [ -LRB- cord-010092-uftc8inx 1235 46 Hb Hb NNP cord-010092-uftc8inx 1235 47 ] ] -RRB- cord-010092-uftc8inx 1235 48 ) ) -RRB- cord-010092-uftc8inx 1235 49 may may MD cord-010092-uftc8inx 1235 50 have have VB cord-010092-uftc8inx 1235 51 on on IN cord-010092-uftc8inx 1235 52 donor donor NN cord-010092-uftc8inx 1235 53 lapse lapse NN cord-010092-uftc8inx 1235 54 . . . cord-010092-uftc8inx 1236 1 In in IN cord-010092-uftc8inx 1236 2 addition addition NN cord-010092-uftc8inx 1236 3 , , , cord-010092-uftc8inx 1236 4 donor donor NN cord-010092-uftc8inx 1236 5 experience experience NN cord-010092-uftc8inx 1236 6 ( ( -LRB- cord-010092-uftc8inx 1236 7 i.e. i.e. FW cord-010092-uftc8inx 1236 8 , , , cord-010092-uftc8inx 1236 9 firsttime firsttime NN cord-010092-uftc8inx 1236 10 or or CC cord-010092-uftc8inx 1236 11 repeat repeat NN cord-010092-uftc8inx 1236 12 donor donor NN cord-010092-uftc8inx 1236 13 ) ) -RRB- cord-010092-uftc8inx 1236 14 has have VBZ cord-010092-uftc8inx 1236 15 also also RB cord-010092-uftc8inx 1236 16 previously previously RB cord-010092-uftc8inx 1236 17 been be VBN cord-010092-uftc8inx 1236 18 found find VBN cord-010092-uftc8inx 1236 19 to to TO cord-010092-uftc8inx 1236 20 affect affect VB cord-010092-uftc8inx 1236 21 donor donor NN cord-010092-uftc8inx 1236 22 lapse lapse NN cord-010092-uftc8inx 1236 23 , , , cord-010092-uftc8inx 1236 24 yet yet CC cord-010092-uftc8inx 1236 25 novice novice JJ cord-010092-uftc8inx 1236 26 ( ( -LRB- cord-010092-uftc8inx 1236 27 1 1 CD cord-010092-uftc8inx 1236 28 - - SYM cord-010092-uftc8inx 1236 29 5 5 CD cord-010092-uftc8inx 1236 30 prior prior JJ cord-010092-uftc8inx 1236 31 donations donation NNS cord-010092-uftc8inx 1236 32 ) ) -RRB- cord-010092-uftc8inx 1236 33 and and CC cord-010092-uftc8inx 1236 34 reactivated reactivate VBN cord-010092-uftc8inx 1236 35 donors donor NNS cord-010092-uftc8inx 1236 36 ( ( -LRB- cord-010092-uftc8inx 1236 37 returning return VBG cord-010092-uftc8inx 1236 38 after after IN cord-010092-uftc8inx 1236 39 years year NNS cord-010092-uftc8inx 1236 40 of of IN cord-010092-uftc8inx 1236 41 not not RB cord-010092-uftc8inx 1236 42 donating donate VBG cord-010092-uftc8inx 1236 43 ) ) -RRB- cord-010092-uftc8inx 1236 44 may may MD cord-010092-uftc8inx 1236 45 respond respond VB cord-010092-uftc8inx 1236 46 differently differently RB cord-010092-uftc8inx 1236 47 . . . cord-010092-uftc8inx 1237 1 Finally finally RB cord-010092-uftc8inx 1237 2 , , , cord-010092-uftc8inx 1237 3 it -PRON- PRP cord-010092-uftc8inx 1237 4 is be VBZ cord-010092-uftc8inx 1237 5 currently currently RB cord-010092-uftc8inx 1237 6 unclear unclear JJ cord-010092-uftc8inx 1237 7 how how WRB cord-010092-uftc8inx 1237 8 and and CC cord-010092-uftc8inx 1237 9 why why WRB cord-010092-uftc8inx 1237 10 different different JJ cord-010092-uftc8inx 1237 11 deferral deferral NN cord-010092-uftc8inx 1237 12 reasons reason NNS cord-010092-uftc8inx 1237 13 and and CC cord-010092-uftc8inx 1237 14 donor donor NN cord-010092-uftc8inx 1237 15 experience experience NN cord-010092-uftc8inx 1237 16 interact interact VBP cord-010092-uftc8inx 1237 17 in in IN cord-010092-uftc8inx 1237 18 influencing influence VBG cord-010092-uftc8inx 1237 19 donor donor NN cord-010092-uftc8inx 1237 20 lapse lapse NN cord-010092-uftc8inx 1237 21 . . . cord-010092-uftc8inx 1238 1 Aims aim VBZ cord-010092-uftc8inx 1238 2 : : : cord-010092-uftc8inx 1239 1 Our -PRON- PRP$ cord-010092-uftc8inx 1239 2 aims aim NNS cord-010092-uftc8inx 1239 3 were be VBD cord-010092-uftc8inx 1239 4 to to TO cord-010092-uftc8inx 1239 5 understand understand VB cord-010092-uftc8inx 1239 6 1 1 CD cord-010092-uftc8inx 1239 7 ) ) -RRB- cord-010092-uftc8inx 1239 8 how how WRB cord-010092-uftc8inx 1239 9 deferral deferral NN cord-010092-uftc8inx 1239 10 reasons reason NNS cord-010092-uftc8inx 1239 11 and and CC cord-010092-uftc8inx 1239 12 donor donor NN cord-010092-uftc8inx 1239 13 experience experience NN cord-010092-uftc8inx 1239 14 jointly jointly RB cord-010092-uftc8inx 1239 15 affect affect VBP cord-010092-uftc8inx 1239 16 donor donor NN cord-010092-uftc8inx 1239 17 lapse lapse NN cord-010092-uftc8inx 1239 18 , , , cord-010092-uftc8inx 1239 19 and and CC cord-010092-uftc8inx 1239 20 2 2 LS cord-010092-uftc8inx 1239 21 ) ) -RRB- cord-010092-uftc8inx 1239 22 why why WRB cord-010092-uftc8inx 1239 23 donors donor NNS cord-010092-uftc8inx 1239 24 may may MD cord-010092-uftc8inx 1239 25 lapse lapse VB cord-010092-uftc8inx 1239 26 after after IN cord-010092-uftc8inx 1239 27 temporary temporary JJ cord-010092-uftc8inx 1239 28 deferral deferral NN cord-010092-uftc8inx 1239 29 . . . cord-010092-uftc8inx 1240 1 Methods method NNS cord-010092-uftc8inx 1240 2 : : : cord-010092-uftc8inx 1241 1 A a DT cord-010092-uftc8inx 1241 2 mixed mixed JJ cord-010092-uftc8inx 1241 3 methods method NNS cord-010092-uftc8inx 1241 4 approach approach NN cord-010092-uftc8inx 1241 5 was be VBD cord-010092-uftc8inx 1241 6 used use VBN cord-010092-uftc8inx 1241 7 . . . cord-010092-uftc8inx 1242 1 First first RB cord-010092-uftc8inx 1242 2 , , , cord-010092-uftc8inx 1242 3 we -PRON- PRP cord-010092-uftc8inx 1242 4 used use VBD cord-010092-uftc8inx 1242 5 Sanquin Sanquin NNP cord-010092-uftc8inx 1242 6 's 's POS cord-010092-uftc8inx 1242 7 donor donor NN cord-010092-uftc8inx 1242 8 database database NN cord-010092-uftc8inx 1242 9 for for IN cord-010092-uftc8inx 1242 10 a a DT cord-010092-uftc8inx 1242 11 quantitative quantitative JJ cord-010092-uftc8inx 1242 12 analysis analysis NN cord-010092-uftc8inx 1242 13 of of IN cord-010092-uftc8inx 1242 14 return return NN cord-010092-uftc8inx 1242 15 behavior behavior NN cord-010092-uftc8inx 1242 16 of of IN cord-010092-uftc8inx 1242 17 all all DT cord-010092-uftc8inx 1242 18 Dutch dutch JJ cord-010092-uftc8inx 1242 19 WB WB NNP cord-010092-uftc8inx 1242 20 donors donor NNS cord-010092-uftc8inx 1242 21 between between IN cord-010092-uftc8inx 1242 22 2013 2013 CD cord-010092-uftc8inx 1242 23 and and CC cord-010092-uftc8inx 1242 24 2015 2015 CD cord-010092-uftc8inx 1243 1 ( ( -LRB- cord-010092-uftc8inx 1243 2 N n NN cord-010092-uftc8inx 1243 3 = = SYM cord-010092-uftc8inx 1243 4 343,564 343,564 CD cord-010092-uftc8inx 1243 5 ) ) -RRB- cord-010092-uftc8inx 1243 6 . . . cord-010092-uftc8inx 1244 1 The the DT cord-010092-uftc8inx 1244 2 first first JJ cord-010092-uftc8inx 1244 3 WB WB NNP cord-010092-uftc8inx 1244 4 donation donation NN cord-010092-uftc8inx 1244 5 for for IN cord-010092-uftc8inx 1244 6 each each DT cord-010092-uftc8inx 1244 7 donor donor NN cord-010092-uftc8inx 1244 8 was be VBD cord-010092-uftc8inx 1244 9 identified identify VBN cord-010092-uftc8inx 1244 10 as as IN cord-010092-uftc8inx 1244 11 the the DT cord-010092-uftc8inx 1244 12 target target NN cord-010092-uftc8inx 1244 13 donation donation NN cord-010092-uftc8inx 1244 14 . . . cord-010092-uftc8inx 1245 1 Lapse lapse NN cord-010092-uftc8inx 1245 2 was be VBD cord-010092-uftc8inx 1245 3 defined define VBN cord-010092-uftc8inx 1245 4 as as IN cord-010092-uftc8inx 1245 5 non non JJ cord-010092-uftc8inx 1245 6 - - JJ cord-010092-uftc8inx 1245 7 return return NN cord-010092-uftc8inx 1245 8 within within IN cord-010092-uftc8inx 1245 9 a a DT cord-010092-uftc8inx 1245 10 followup followup JJ cord-010092-uftc8inx 1245 11 period period NN cord-010092-uftc8inx 1245 12 of of IN cord-010092-uftc8inx 1245 13 two two CD cord-010092-uftc8inx 1245 14 years year NNS cord-010092-uftc8inx 1245 15 after after IN cord-010092-uftc8inx 1245 16 the the DT cord-010092-uftc8inx 1245 17 target target NN cord-010092-uftc8inx 1245 18 donation donation NN cord-010092-uftc8inx 1245 19 . . . cord-010092-uftc8inx 1246 1 Target target NN cord-010092-uftc8inx 1246 2 donations donation NNS cord-010092-uftc8inx 1246 3 included include VBD cord-010092-uftc8inx 1246 4 25 25 CD cord-010092-uftc8inx 1246 5 % % NN cord-010092-uftc8inx 1246 6 new new JJ cord-010092-uftc8inx 1246 7 donors donor NNS cord-010092-uftc8inx 1246 8 , , , cord-010092-uftc8inx 1246 9 41 41 CD cord-010092-uftc8inx 1246 10 % % NN cord-010092-uftc8inx 1246 11 novice novice NN cord-010092-uftc8inx 1246 12 donors donor NNS cord-010092-uftc8inx 1246 13 , , , cord-010092-uftc8inx 1246 14 30 30 CD cord-010092-uftc8inx 1246 15 % % NN cord-010092-uftc8inx 1246 16 experienced experienced JJ cord-010092-uftc8inx 1246 17 donors donor NNS cord-010092-uftc8inx 1246 18 , , , cord-010092-uftc8inx 1246 19 and and CC cord-010092-uftc8inx 1246 20 4 4 CD cord-010092-uftc8inx 1246 21 % % NN cord-010092-uftc8inx 1246 22 reactivated reactivate VBN cord-010092-uftc8inx 1246 23 donors donor NNS cord-010092-uftc8inx 1246 24 . . . cord-010092-uftc8inx 1247 1 Deferral deferral NN cord-010092-uftc8inx 1247 2 reasons reason NNS cord-010092-uftc8inx 1247 3 included include VBD cord-010092-uftc8inx 1247 4 travel travel NN cord-010092-uftc8inx 1247 5 , , , cord-010092-uftc8inx 1247 6 Hb Hb NNP cord-010092-uftc8inx 1247 7 , , , cord-010092-uftc8inx 1247 8 medical medical JJ cord-010092-uftc8inx 1247 9 short short JJ cord-010092-uftc8inx 1247 10 - - HYPH cord-010092-uftc8inx 1247 11 term term NN cord-010092-uftc8inx 1247 12 ( ( -LRB- cord-010092-uftc8inx 1247 13 < < NNP cord-010092-uftc8inx 1247 14 28 28 CD cord-010092-uftc8inx 1247 15 days day NNS cord-010092-uftc8inx 1247 16 duration duration NN cord-010092-uftc8inx 1247 17 ) ) -RRB- cord-010092-uftc8inx 1247 18 , , , cord-010092-uftc8inx 1247 19 medical medical JJ cord-010092-uftc8inx 1247 20 long long JJ cord-010092-uftc8inx 1247 21 - - HYPH cord-010092-uftc8inx 1247 22 term term NN cord-010092-uftc8inx 1247 23 ( ( -LRB- cord-010092-uftc8inx 1247 24 > > NFP cord-010092-uftc8inx 1247 25 28 28 CD cord-010092-uftc8inx 1247 26 days day NNS cord-010092-uftc8inx 1247 27 duration duration NN cord-010092-uftc8inx 1247 28 ) ) -RRB- cord-010092-uftc8inx 1247 29 , , , cord-010092-uftc8inx 1247 30 and and CC cord-010092-uftc8inx 1247 31 miscellaneous miscellaneous JJ cord-010092-uftc8inx 1247 32 . . . cord-010092-uftc8inx 1248 1 Next next RB cord-010092-uftc8inx 1248 2 , , , cord-010092-uftc8inx 1248 3 we -PRON- PRP cord-010092-uftc8inx 1248 4 interviewed interview VBD cord-010092-uftc8inx 1248 5 31 31 CD cord-010092-uftc8inx 1248 6 temporarily temporarily RB cord-010092-uftc8inx 1248 7 deferred defer VBD cord-010092-uftc8inx 1248 8 donors donor NNS cord-010092-uftc8inx 1248 9 to to TO cord-010092-uftc8inx 1248 10 understand understand VB cord-010092-uftc8inx 1248 11 the the DT cord-010092-uftc8inx 1248 12 deferral deferral NN cord-010092-uftc8inx 1248 13 process process NN cord-010092-uftc8inx 1248 14 from from IN cord-010092-uftc8inx 1248 15 their -PRON- PRP$ cord-010092-uftc8inx 1248 16 perspective perspective NN cord-010092-uftc8inx 1248 17 . . . cord-010092-uftc8inx 1249 1 Semi semi JJ cord-010092-uftc8inx 1249 2 - - JJ cord-010092-uftc8inx 1249 3 structured structured JJ cord-010092-uftc8inx 1249 4 interviews interview NNS cord-010092-uftc8inx 1249 5 were be VBD cord-010092-uftc8inx 1249 6 used use VBN cord-010092-uftc8inx 1249 7 to to TO cord-010092-uftc8inx 1249 8 understand understand VB cord-010092-uftc8inx 1249 9 how how WRB cord-010092-uftc8inx 1249 10 these these DT cord-010092-uftc8inx 1249 11 donors donor NNS cord-010092-uftc8inx 1249 12 cognitively cognitively RB cord-010092-uftc8inx 1249 13 and and CC cord-010092-uftc8inx 1249 14 emotionally emotionally RB cord-010092-uftc8inx 1249 15 experienced experienced JJ cord-010092-uftc8inx 1249 16 on on IN cord-010092-uftc8inx 1249 17 - - HYPH cord-010092-uftc8inx 1249 18 site site NN cord-010092-uftc8inx 1249 19 temporary temporary JJ cord-010092-uftc8inx 1249 20 deferral deferral NN cord-010092-uftc8inx 1249 21 . . . cord-010092-uftc8inx 1250 1 We -PRON- PRP cord-010092-uftc8inx 1250 2 analyzed analyze VBD cord-010092-uftc8inx 1250 3 the the DT cord-010092-uftc8inx 1250 4 interviews interview NNS cord-010092-uftc8inx 1250 5 ( ( -LRB- cord-010092-uftc8inx 1250 6 using use VBG cord-010092-uftc8inx 1250 7 the the DT cord-010092-uftc8inx 1250 8 Framework Framework NNP cord-010092-uftc8inx 1250 9 approach approach NN cord-010092-uftc8inx 1250 10 , , , cord-010092-uftc8inx 1250 11 cf cf NNP cord-010092-uftc8inx 1250 12 . . . cord-010092-uftc8inx 1251 1 Hillgrove Hillgrove NNP cord-010092-uftc8inx 1251 2 et et FW cord-010092-uftc8inx 1251 3 al al NNP cord-010092-uftc8inx 1251 4 . . . cord-010092-uftc8inx 1252 1 , , , cord-010092-uftc8inx 1252 2 BMC BMC NNP cord-010092-uftc8inx 1252 3 Public Public NNP cord-010092-uftc8inx 1252 4 Health Health NNP cord-010092-uftc8inx 1252 5 , , , cord-010092-uftc8inx 1252 6 2012 2012 CD cord-010092-uftc8inx 1252 7 ) ) -RRB- cord-010092-uftc8inx 1253 1 to to TO cord-010092-uftc8inx 1253 2 identify identify VB cord-010092-uftc8inx 1253 3 key key JJ cord-010092-uftc8inx 1253 4 topics topic NNS cord-010092-uftc8inx 1253 5 and and CC cord-010092-uftc8inx 1253 6 underlying underlying JJ cord-010092-uftc8inx 1253 7 themes theme NNS cord-010092-uftc8inx 1253 8 . . . cord-010092-uftc8inx 1254 1 Results result NNS cord-010092-uftc8inx 1254 2 : : : cord-010092-uftc8inx 1255 1 Of of IN cord-010092-uftc8inx 1255 2 target target NN cord-010092-uftc8inx 1255 3 donations donation NNS cord-010092-uftc8inx 1255 4 , , , cord-010092-uftc8inx 1255 5 11 11 CD cord-010092-uftc8inx 1255 6 % % NN cord-010092-uftc8inx 1255 7 were be VBD cord-010092-uftc8inx 1255 8 deferred defer VBN cord-010092-uftc8inx 1255 9 , , , cord-010092-uftc8inx 1255 10 mostly mostly RB cord-010092-uftc8inx 1255 11 for for IN cord-010092-uftc8inx 1255 12 travel travel NN cord-010092-uftc8inx 1255 13 ( ( -LRB- cord-010092-uftc8inx 1255 14 40 40 CD cord-010092-uftc8inx 1255 15 % % NN cord-010092-uftc8inx 1255 16 ) ) -RRB- cord-010092-uftc8inx 1255 17 , , , cord-010092-uftc8inx 1255 18 medical medical JJ cord-010092-uftc8inx 1255 19 short short JJ cord-010092-uftc8inx 1255 20 - - HYPH cord-010092-uftc8inx 1255 21 term term NN cord-010092-uftc8inx 1255 22 ( ( -LRB- cord-010092-uftc8inx 1255 23 23 23 CD cord-010092-uftc8inx 1255 24 % % NN cord-010092-uftc8inx 1255 25 ) ) -RRB- cord-010092-uftc8inx 1255 26 , , , cord-010092-uftc8inx 1255 27 and and CC cord-010092-uftc8inx 1255 28 Hb Hb NNP cord-010092-uftc8inx 1255 29 ( ( -LRB- cord-010092-uftc8inx 1255 30 19 19 CD cord-010092-uftc8inx 1255 31 % % NN cord-010092-uftc8inx 1255 32 ) ) -RRB- cord-010092-uftc8inx 1255 33 . . . cord-010092-uftc8inx 1256 1 Survival survival NN cord-010092-uftc8inx 1256 2 and and CC cord-010092-uftc8inx 1256 3 time time NN cord-010092-uftc8inx 1256 4 - - HYPH cord-010092-uftc8inx 1256 5 to to IN cord-010092-uftc8inx 1256 6 - - HYPH cord-010092-uftc8inx 1256 7 events event NNS cord-010092-uftc8inx 1256 8 methods method NNS cord-010092-uftc8inx 1256 9 showed show VBD cord-010092-uftc8inx 1256 10 that that IN cord-010092-uftc8inx 1256 11 the the DT cord-010092-uftc8inx 1256 12 different different JJ cord-010092-uftc8inx 1256 13 deferral deferral NN cord-010092-uftc8inx 1256 14 reasons reason NNS cord-010092-uftc8inx 1256 15 and and CC cord-010092-uftc8inx 1256 16 donor donor NN cord-010092-uftc8inx 1256 17 experience experience NN cord-010092-uftc8inx 1256 18 levels level NNS cord-010092-uftc8inx 1256 19 differentially differentially RB cord-010092-uftc8inx 1256 20 impacted impact VBN cord-010092-uftc8inx 1256 21 donor donor NN cord-010092-uftc8inx 1256 22 return return NN cord-010092-uftc8inx 1256 23 or or CC cord-010092-uftc8inx 1256 24 lapse lapse NN cord-010092-uftc8inx 1256 25 . . . cord-010092-uftc8inx 1257 1 Importantly importantly RB cord-010092-uftc8inx 1257 2 , , , cord-010092-uftc8inx 1257 3 experience experience NN cord-010092-uftc8inx 1257 4 and and CC cord-010092-uftc8inx 1257 5 deferral deferral NN cord-010092-uftc8inx 1257 6 interacted interact VBN cord-010092-uftc8inx 1257 7 in in IN cord-010092-uftc8inx 1257 8 influencing influence VBG cord-010092-uftc8inx 1257 9 return return NN cord-010092-uftc8inx 1257 10 ( ( -LRB- cord-010092-uftc8inx 1257 11 rate rate NN cord-010092-uftc8inx 1257 12 ) ) -RRB- cord-010092-uftc8inx 1257 13 . . . cord-010092-uftc8inx 1258 1 For for IN cord-010092-uftc8inx 1258 2 instance instance NN cord-010092-uftc8inx 1258 3 , , , cord-010092-uftc8inx 1258 4 deferred defer VBD cord-010092-uftc8inx 1258 5 new new JJ cord-010092-uftc8inx 1258 6 donors donor NNS cord-010092-uftc8inx 1258 7 were be VBD cord-010092-uftc8inx 1258 8 more more RBR cord-010092-uftc8inx 1258 9 likely likely JJ cord-010092-uftc8inx 1258 10 to to TO cord-010092-uftc8inx 1258 11 lapse lapse VB cord-010092-uftc8inx 1258 12 than than IN cord-010092-uftc8inx 1258 13 eligible eligible JJ cord-010092-uftc8inx 1258 14 or or CC cord-010092-uftc8inx 1258 15 experienced experienced JJ cord-010092-uftc8inx 1258 16 donors donor NNS cord-010092-uftc8inx 1258 17 ( ( -LRB- cord-010092-uftc8inx 1258 18 ORs or NNS cord-010092-uftc8inx 1258 19 < < XX cord-010092-uftc8inx 1258 20 0.75 0.75 XX cord-010092-uftc8inx 1258 21 , , , cord-010092-uftc8inx 1258 22 p's<0.001 p's<0.001 NNP cord-010092-uftc8inx 1258 23 ) ) -RRB- cord-010092-uftc8inx 1258 24 . . . cord-010092-uftc8inx 1259 1 Even even RB cord-010092-uftc8inx 1259 2 though though IN cord-010092-uftc8inx 1259 3 deferral deferral NN cord-010092-uftc8inx 1259 4 also also RB cord-010092-uftc8inx 1259 5 affected affect VBD cord-010092-uftc8inx 1259 6 return return NN cord-010092-uftc8inx 1259 7 of of IN cord-010092-uftc8inx 1259 8 experienced experienced JJ cord-010092-uftc8inx 1259 9 donors donor NNS cord-010092-uftc8inx 1259 10 , , , cord-010092-uftc8inx 1259 11 this this DT cord-010092-uftc8inx 1259 12 effect effect NN cord-010092-uftc8inx 1259 13 was be VBD cord-010092-uftc8inx 1259 14 smaller small JJR cord-010092-uftc8inx 1259 15 or or CC cord-010092-uftc8inx 1259 16 even even RB cord-010092-uftc8inx 1259 17 non non JJ cord-010092-uftc8inx 1259 18 - - JJ cord-010092-uftc8inx 1259 19 existent existent JJ cord-010092-uftc8inx 1259 20 for for IN cord-010092-uftc8inx 1259 21 certain certain JJ cord-010092-uftc8inx 1259 22 deferral deferral NN cord-010092-uftc8inx 1259 23 reasons reason NNS cord-010092-uftc8inx 1259 24 ( ( -LRB- cord-010092-uftc8inx 1259 25 e.g. e.g. RB cord-010092-uftc8inx 1259 26 , , , cord-010092-uftc8inx 1259 27 travel travel NN cord-010092-uftc8inx 1259 28 - - : cord-010092-uftc8inx 1259 29 and and CC cord-010092-uftc8inx 1259 30 Hb Hb NNP cord-010092-uftc8inx 1259 31 - - HYPH cord-010092-uftc8inx 1259 32 related relate VBN cord-010092-uftc8inx 1259 33 deferrals deferral NNS cord-010092-uftc8inx 1259 34 ) ) -RRB- cord-010092-uftc8inx 1259 35 . . . cord-010092-uftc8inx 1260 1 Qualitative qualitative JJ cord-010092-uftc8inx 1260 2 results result NNS cord-010092-uftc8inx 1260 3 showed show VBD cord-010092-uftc8inx 1260 4 that that IN cord-010092-uftc8inx 1260 5 almost almost RB cord-010092-uftc8inx 1260 6 all all DT cord-010092-uftc8inx 1260 7 donors donor NNS cord-010092-uftc8inx 1260 8 experienced experience VBD cord-010092-uftc8inx 1260 9 temporary temporary JJ cord-010092-uftc8inx 1260 10 deferral deferral NN cord-010092-uftc8inx 1260 11 as as IN cord-010092-uftc8inx 1260 12 disappointing disappointing JJ cord-010092-uftc8inx 1260 13 , , , cord-010092-uftc8inx 1260 14 particularly particularly RB cord-010092-uftc8inx 1260 15 when when WRB cord-010092-uftc8inx 1260 16 it -PRON- PRP cord-010092-uftc8inx 1260 17 was be VBD cord-010092-uftc8inx 1260 18 unexpected unexpected JJ cord-010092-uftc8inx 1260 19 ( ( -LRB- cord-010092-uftc8inx 1260 20 e.g. e.g. RB cord-010092-uftc8inx 1260 21 , , , cord-010092-uftc8inx 1260 22 first first JJ cord-010092-uftc8inx 1260 23 - - HYPH cord-010092-uftc8inx 1260 24 time time NN cord-010092-uftc8inx 1260 25 deferral deferral NN cord-010092-uftc8inx 1260 26 ) ) -RRB- cord-010092-uftc8inx 1260 27 . . . cord-010092-uftc8inx 1261 1 Not not RB cord-010092-uftc8inx 1261 2 all all DT cord-010092-uftc8inx 1261 3 donors donor NNS cord-010092-uftc8inx 1261 4 ( ( -LRB- cord-010092-uftc8inx 1261 5 fully fully RB cord-010092-uftc8inx 1261 6 ) ) -RRB- cord-010092-uftc8inx 1261 7 understood understand VBD cord-010092-uftc8inx 1261 8 the the DT cord-010092-uftc8inx 1261 9 aims aim NNS cord-010092-uftc8inx 1261 10 of of IN cord-010092-uftc8inx 1261 11 deferral deferral NN cord-010092-uftc8inx 1261 12 or or CC cord-010092-uftc8inx 1261 13 how how WRB cord-010092-uftc8inx 1261 14 to to TO cord-010092-uftc8inx 1261 15 prevent prevent VB cord-010092-uftc8inx 1261 16 on on IN cord-010092-uftc8inx 1261 17 - - HYPH cord-010092-uftc8inx 1261 18 site site NN cord-010092-uftc8inx 1261 19 deferral deferral NN cord-010092-uftc8inx 1261 20 . . . cord-010092-uftc8inx 1262 1 Donor donor NN cord-010092-uftc8inx 1262 2 beliefs belief NNS cord-010092-uftc8inx 1262 3 about about IN cord-010092-uftc8inx 1262 4 why why WRB cord-010092-uftc8inx 1262 5 deferral deferral NN cord-010092-uftc8inx 1262 6 would would MD cord-010092-uftc8inx 1262 7 lead lead VB cord-010092-uftc8inx 1262 8 to to TO cord-010092-uftc8inx 1262 9 lapse lapse NN cord-010092-uftc8inx 1262 10 were be VBD cord-010092-uftc8inx 1262 11 related relate VBN cord-010092-uftc8inx 1262 12 to to IN cord-010092-uftc8inx 1262 13 recurring recur VBG cord-010092-uftc8inx 1262 14 deferrals deferral NNS cord-010092-uftc8inx 1262 15 , , , cord-010092-uftc8inx 1262 16 ( ( -LRB- cord-010092-uftc8inx 1262 17 mistakenly mistakenly RB cord-010092-uftc8inx 1262 18 ) ) -RRB- cord-010092-uftc8inx 1262 19 interpreting interpret VBG cord-010092-uftc8inx 1262 20 deferral deferral NN cord-010092-uftc8inx 1262 21 as as IN cord-010092-uftc8inx 1262 22 permanent permanent JJ cord-010092-uftc8inx 1262 23 , , , cord-010092-uftc8inx 1262 24 or or CC cord-010092-uftc8inx 1262 25 feeling feel VBG cord-010092-uftc8inx 1262 26 all all PDT cord-010092-uftc8inx 1262 27 the the DT cord-010092-uftc8inx 1262 28 effort effort NN cord-010092-uftc8inx 1262 29 did do VBD cord-010092-uftc8inx 1262 30 not not RB cord-010092-uftc8inx 1262 31 pay pay VB cord-010092-uftc8inx 1262 32 off off RP cord-010092-uftc8inx 1262 33 . . . cord-010092-uftc8inx 1263 1 Summary Summary NNP cord-010092-uftc8inx 1263 2 / / SYM cord-010092-uftc8inx 1263 3 Conclusions conclusion NNS cord-010092-uftc8inx 1263 4 : : : cord-010092-uftc8inx 1263 5 Reasons reason NNS cord-010092-uftc8inx 1263 6 for for IN cord-010092-uftc8inx 1263 7 temporary temporary JJ cord-010092-uftc8inx 1263 8 deferral deferral NN cord-010092-uftc8inx 1263 9 differently differently RB cord-010092-uftc8inx 1263 10 impact impact NN cord-010092-uftc8inx 1263 11 risks risk NNS cord-010092-uftc8inx 1263 12 of of IN cord-010092-uftc8inx 1263 13 donor donor NN cord-010092-uftc8inx 1263 14 lapse lapse NN cord-010092-uftc8inx 1263 15 at at IN cord-010092-uftc8inx 1263 16 different different JJ cord-010092-uftc8inx 1263 17 levels level NNS cord-010092-uftc8inx 1263 18 of of IN cord-010092-uftc8inx 1263 19 donor donor NN cord-010092-uftc8inx 1263 20 experience experience NN cord-010092-uftc8inx 1263 21 . . . cord-010092-uftc8inx 1264 1 For for IN cord-010092-uftc8inx 1264 2 new new JJ cord-010092-uftc8inx 1264 3 donors donor NNS cord-010092-uftc8inx 1264 4 all all DT cord-010092-uftc8inx 1264 5 reasons reason NNS cord-010092-uftc8inx 1264 6 for for IN cord-010092-uftc8inx 1264 7 deferral deferral NN cord-010092-uftc8inx 1264 8 are be VBP cord-010092-uftc8inx 1264 9 related relate VBN cord-010092-uftc8inx 1264 10 to to IN cord-010092-uftc8inx 1264 11 higher high JJR cord-010092-uftc8inx 1264 12 risks risk NNS cord-010092-uftc8inx 1264 13 of of IN cord-010092-uftc8inx 1264 14 lapse lapse NN cord-010092-uftc8inx 1264 15 , , , cord-010092-uftc8inx 1264 16 whereas whereas IN cord-010092-uftc8inx 1264 17 some some DT cord-010092-uftc8inx 1264 18 reasons reason NNS cord-010092-uftc8inx 1264 19 for for IN cord-010092-uftc8inx 1264 20 deferral deferral NN cord-010092-uftc8inx 1264 21 seem seem VBP cord-010092-uftc8inx 1264 22 not not RB cord-010092-uftc8inx 1264 23 to to TO cord-010092-uftc8inx 1264 24 affect affect VB cord-010092-uftc8inx 1264 25 lapse lapse NN cord-010092-uftc8inx 1264 26 among among IN cord-010092-uftc8inx 1264 27 more more RBR cord-010092-uftc8inx 1264 28 experienced experienced JJ cord-010092-uftc8inx 1264 29 donors donor NNS cord-010092-uftc8inx 1264 30 . . . cord-010092-uftc8inx 1265 1 Unexpected unexpected JJ cord-010092-uftc8inx 1265 2 or or CC cord-010092-uftc8inx 1265 3 recurring recur VBG cord-010092-uftc8inx 1265 4 deferrals deferral NNS cord-010092-uftc8inx 1265 5 may may MD cord-010092-uftc8inx 1265 6 explain explain VB cord-010092-uftc8inx 1265 7 why why WRB cord-010092-uftc8inx 1265 8 donors donor NNS cord-010092-uftc8inx 1265 9 lapse lapse VBP cord-010092-uftc8inx 1265 10 after after IN cord-010092-uftc8inx 1265 11 temporary temporary JJ cord-010092-uftc8inx 1265 12 deferral deferral NN cord-010092-uftc8inx 1265 13 . . . cord-010092-uftc8inx 1266 1 Blood blood NN cord-010092-uftc8inx 1266 2 banks bank NNS cord-010092-uftc8inx 1266 3 may may MD cord-010092-uftc8inx 1266 4 tackle tackle VB cord-010092-uftc8inx 1266 5 disappointment disappointment NN cord-010092-uftc8inx 1266 6 after after IN cord-010092-uftc8inx 1266 7 deferral deferral NN cord-010092-uftc8inx 1266 8 by by IN cord-010092-uftc8inx 1266 9 explicitly explicitly RB cord-010092-uftc8inx 1266 10 showing show VBG cord-010092-uftc8inx 1266 11 that that IN cord-010092-uftc8inx 1266 12 the the DT cord-010092-uftc8inx 1266 13 donor donor NN cord-010092-uftc8inx 1266 14 is be VBZ cord-010092-uftc8inx 1266 15 still still RB cord-010092-uftc8inx 1266 16 valued value VBN cord-010092-uftc8inx 1266 17 , , , cord-010092-uftc8inx 1266 18 for for IN cord-010092-uftc8inx 1266 19 instance instance NN cord-010092-uftc8inx 1266 20 by by IN cord-010092-uftc8inx 1266 21 using use VBG cord-010092-uftc8inx 1266 22 personalized personalized JJ cord-010092-uftc8inx 1266 23 communication communication NN cord-010092-uftc8inx 1266 24 or or CC cord-010092-uftc8inx 1266 25 offering offer VBG cord-010092-uftc8inx 1266 26 an an DT cord-010092-uftc8inx 1266 27 alternative alternative JJ cord-010092-uftc8inx 1266 28 good good JJ cord-010092-uftc8inx 1266 29 deed deed NN cord-010092-uftc8inx 1266 30 . . . cord-010092-uftc8inx 1267 1 Background background NN cord-010092-uftc8inx 1267 2 : : : cord-010092-uftc8inx 1268 1 Blood blood NN cord-010092-uftc8inx 1268 2 donors donor NNS cord-010092-uftc8inx 1268 3 experience experience VBP cord-010092-uftc8inx 1268 4 a a DT cord-010092-uftc8inx 1268 5 temporary temporary JJ cord-010092-uftc8inx 1268 6 reduction reduction NN cord-010092-uftc8inx 1268 7 in in IN cord-010092-uftc8inx 1268 8 their -PRON- PRP$ cord-010092-uftc8inx 1268 9 hemoglobin hemoglobin NN cord-010092-uftc8inx 1268 10 ( ( -LRB- cord-010092-uftc8inx 1268 11 Hb Hb NNP cord-010092-uftc8inx 1268 12 ) ) -RRB- cord-010092-uftc8inx 1268 13 value value NN cord-010092-uftc8inx 1268 14 after after IN cord-010092-uftc8inx 1268 15 whole whole JJ cord-010092-uftc8inx 1268 16 blood blood NN cord-010092-uftc8inx 1268 17 donation donation NN cord-010092-uftc8inx 1268 18 . . . cord-010092-uftc8inx 1269 1 In in IN cord-010092-uftc8inx 1269 2 the the DT cord-010092-uftc8inx 1269 3 Netherlands Netherlands NNP cord-010092-uftc8inx 1269 4 , , , cord-010092-uftc8inx 1269 5 the the DT cord-010092-uftc8inx 1269 6 Hb Hb NNP cord-010092-uftc8inx 1269 7 value value NN cord-010092-uftc8inx 1269 8 is be VBZ cord-010092-uftc8inx 1269 9 measured measure VBN cord-010092-uftc8inx 1269 10 before before IN cord-010092-uftc8inx 1269 11 each each DT cord-010092-uftc8inx 1269 12 donation donation NN cord-010092-uftc8inx 1269 13 , , , cord-010092-uftc8inx 1269 14 and and CC cord-010092-uftc8inx 1269 15 a a DT cord-010092-uftc8inx 1269 16 too too RB cord-010092-uftc8inx 1269 17 low low JJ cord-010092-uftc8inx 1269 18 Hb Hb NNP cord-010092-uftc8inx 1269 19 value value NN cord-010092-uftc8inx 1269 20 ( ( -LRB- cord-010092-uftc8inx 1269 21 cut cut VB cord-010092-uftc8inx 1269 22 - - HYPH cord-010092-uftc8inx 1269 23 off off RP cord-010092-uftc8inx 1269 24 values value NNS cord-010092-uftc8inx 1269 25 : : : cord-010092-uftc8inx 1269 26 8.4 8.4 CD cord-010092-uftc8inx 1269 27 mmol mmol NNP cord-010092-uftc8inx 1269 28 / / SYM cord-010092-uftc8inx 1269 29 l l NN cord-010092-uftc8inx 1269 30 ( ( -LRB- cord-010092-uftc8inx 1269 31 135 135 CD cord-010092-uftc8inx 1269 32 g g NN cord-010092-uftc8inx 1269 33 / / SYM cord-010092-uftc8inx 1269 34 l l NN cord-010092-uftc8inx 1269 35 ) ) -RRB- cord-010092-uftc8inx 1269 36 for for IN cord-010092-uftc8inx 1269 37 men man NNS cord-010092-uftc8inx 1269 38 and and CC cord-010092-uftc8inx 1269 39 7.8 7.8 CD cord-010092-uftc8inx 1269 40 mmol mmol JJ cord-010092-uftc8inx 1269 41 / / SYM cord-010092-uftc8inx 1269 42 l l NN cord-010092-uftc8inx 1269 43 ( ( -LRB- cord-010092-uftc8inx 1269 44 125 125 CD cord-010092-uftc8inx 1269 45 g g NN cord-010092-uftc8inx 1269 46 / / SYM cord-010092-uftc8inx 1269 47 l l NN cord-010092-uftc8inx 1269 48 ) ) -RRB- cord-010092-uftc8inx 1269 49 for for IN cord-010092-uftc8inx 1269 50 women woman NNS cord-010092-uftc8inx 1269 51 ) ) -RRB- cord-010092-uftc8inx 1269 52 leads lead VBZ cord-010092-uftc8inx 1269 53 to to IN cord-010092-uftc8inx 1269 54 a a DT cord-010092-uftc8inx 1269 55 deferral deferral NN cord-010092-uftc8inx 1269 56 for for IN cord-010092-uftc8inx 1269 57 donation donation NN cord-010092-uftc8inx 1269 58 , , , cord-010092-uftc8inx 1269 59 in in IN cord-010092-uftc8inx 1269 60 order order NN cord-010092-uftc8inx 1269 61 to to TO cord-010092-uftc8inx 1269 62 prevent prevent VB cord-010092-uftc8inx 1269 63 iron iron NN cord-010092-uftc8inx 1269 64 deficiency deficiency NN cord-010092-uftc8inx 1269 65 and and CC cord-010092-uftc8inx 1269 66 anaemia anaemia NN cord-010092-uftc8inx 1269 67 . . . cord-010092-uftc8inx 1270 1 The the DT cord-010092-uftc8inx 1270 2 minimum minimum JJ cord-010092-uftc8inx 1270 3 interval interval NN cord-010092-uftc8inx 1270 4 between between IN cord-010092-uftc8inx 1270 5 two two CD cord-010092-uftc8inx 1270 6 donations donation NNS cord-010092-uftc8inx 1270 7 is be VBZ cord-010092-uftc8inx 1270 8 internationally internationally RB cord-010092-uftc8inx 1270 9 set set VBN cord-010092-uftc8inx 1270 10 at at IN cord-010092-uftc8inx 1270 11 8 8 CD cord-010092-uftc8inx 1270 12 weeks week NNS cord-010092-uftc8inx 1270 13 , , , cord-010092-uftc8inx 1270 14 but but CC cord-010092-uftc8inx 1270 15 over over IN cord-010092-uftc8inx 1270 16 time time NN cord-010092-uftc8inx 1270 17 donors donor NNS cord-010092-uftc8inx 1270 18 exhibit exhibit VBP cord-010092-uftc8inx 1270 19 iron iron NN cord-010092-uftc8inx 1270 20 deficiency deficiency NN cord-010092-uftc8inx 1270 21 so so IN cord-010092-uftc8inx 1270 22 that that IN cord-010092-uftc8inx 1270 23 blood blood NN cord-010092-uftc8inx 1270 24 donors donor NNS cord-010092-uftc8inx 1270 25 are be VBP cord-010092-uftc8inx 1270 26 temporarily temporarily RB cord-010092-uftc8inx 1270 27 deferred defer VBN cord-010092-uftc8inx 1270 28 from from IN cord-010092-uftc8inx 1270 29 donation donation NN cord-010092-uftc8inx 1270 30 each each DT cord-010092-uftc8inx 1270 31 year year NN cord-010092-uftc8inx 1270 32 . . . cord-010092-uftc8inx 1271 1 In in IN cord-010092-uftc8inx 1271 2 the the DT cord-010092-uftc8inx 1271 3 US US NNP cord-010092-uftc8inx 1271 4 35 35 CD cord-010092-uftc8inx 1271 5 % % NN cord-010092-uftc8inx 1271 6 -75 -75 CD cord-010092-uftc8inx 1271 7 % % NN cord-010092-uftc8inx 1271 8 of of IN cord-010092-uftc8inx 1271 9 deferrals deferral NNS cord-010092-uftc8inx 1271 10 are be VBP cord-010092-uftc8inx 1271 11 due due JJ cord-010092-uftc8inx 1271 12 to to IN cord-010092-uftc8inx 1271 13 low low JJ cord-010092-uftc8inx 1271 14 Hb Hb NNP cord-010092-uftc8inx 1271 15 , , , cord-010092-uftc8inx 1271 16 especially especially RB cord-010092-uftc8inx 1271 17 in in IN cord-010092-uftc8inx 1271 18 women woman NNS cord-010092-uftc8inx 1271 19 ( ( -LRB- cord-010092-uftc8inx 1271 20 Editorial Editorial NNP cord-010092-uftc8inx 1271 21 , , , cord-010092-uftc8inx 1271 22 Transfusion Transfusion NNP cord-010092-uftc8inx 1271 23 , , , cord-010092-uftc8inx 1271 24 2012 2012 CD cord-010092-uftc8inx 1271 25 ) ) -RRB- cord-010092-uftc8inx 1271 26 . . . cord-010092-uftc8inx 1272 1 Due due IN cord-010092-uftc8inx 1272 2 to to IN cord-010092-uftc8inx 1272 3 the the DT cord-010092-uftc8inx 1272 4 recovery recovery NN cord-010092-uftc8inx 1272 5 process process NN cord-010092-uftc8inx 1272 6 after after IN cord-010092-uftc8inx 1272 7 each each DT cord-010092-uftc8inx 1272 8 donation donation NN cord-010092-uftc8inx 1272 9 and and CC cord-010092-uftc8inx 1272 10 the the DT cord-010092-uftc8inx 1272 11 unobserved unobserved JJ cord-010092-uftc8inx 1272 12 heterogeneity heterogeneity NN cord-010092-uftc8inx 1272 13 of of IN cord-010092-uftc8inx 1272 14 donors donor NNS cord-010092-uftc8inx 1272 15 , , , cord-010092-uftc8inx 1272 16 advanced advanced JJ cord-010092-uftc8inx 1272 17 statistical statistical JJ cord-010092-uftc8inx 1272 18 methods method NNS cord-010092-uftc8inx 1272 19 are be VBP cord-010092-uftc8inx 1272 20 needed need VBN cord-010092-uftc8inx 1272 21 to to TO cord-010092-uftc8inx 1272 22 model model VB cord-010092-uftc8inx 1272 23 the the DT cord-010092-uftc8inx 1272 24 longitudinal longitudinal JJ cord-010092-uftc8inx 1272 25 data datum NNS cord-010092-uftc8inx 1272 26 of of IN cord-010092-uftc8inx 1272 27 Hb Hb NNP cord-010092-uftc8inx 1272 28 values value NNS cord-010092-uftc8inx 1272 29 of of IN cord-010092-uftc8inx 1272 30 blood blood NN cord-010092-uftc8inx 1272 31 donors donor NNS cord-010092-uftc8inx 1272 32 . . . cord-010092-uftc8inx 1273 1 Aims aim VBZ cord-010092-uftc8inx 1273 2 : : : cord-010092-uftc8inx 1274 1 To to TO cord-010092-uftc8inx 1274 2 estimate estimate VB cord-010092-uftc8inx 1274 3 the the DT cord-010092-uftc8inx 1274 4 shape shape NN cord-010092-uftc8inx 1274 5 and and CC cord-010092-uftc8inx 1274 6 duration duration NN cord-010092-uftc8inx 1274 7 of of IN cord-010092-uftc8inx 1274 8 the the DT cord-010092-uftc8inx 1274 9 recovery recovery NN cord-010092-uftc8inx 1274 10 process process NN cord-010092-uftc8inx 1274 11 of of IN cord-010092-uftc8inx 1274 12 Hb Hb NNP cord-010092-uftc8inx 1274 13 until until IN cord-010092-uftc8inx 1274 14 the the DT cord-010092-uftc8inx 1274 15 Hb Hb NNP cord-010092-uftc8inx 1274 16 value value NN cord-010092-uftc8inx 1274 17 has have VBZ cord-010092-uftc8inx 1274 18 returned return VBN cord-010092-uftc8inx 1274 19 to to IN cord-010092-uftc8inx 1274 20 its -PRON- PRP$ cord-010092-uftc8inx 1274 21 pre pre JJ cord-010092-uftc8inx 1274 22 - - JJ cord-010092-uftc8inx 1274 23 donation donation JJ cord-010092-uftc8inx 1274 24 level level NN cord-010092-uftc8inx 1274 25 , , , cord-010092-uftc8inx 1274 26 to to TO cord-010092-uftc8inx 1274 27 assess assess VB cord-010092-uftc8inx 1274 28 whether whether IN cord-010092-uftc8inx 1274 29 one one PRP cord-010092-uftc8inx 1274 30 can can MD cord-010092-uftc8inx 1274 31 distinguish distinguish VB cord-010092-uftc8inx 1274 32 between between IN cord-010092-uftc8inx 1274 33 donors donor NNS cord-010092-uftc8inx 1274 34 with with IN cord-010092-uftc8inx 1274 35 fast fast JJ cord-010092-uftc8inx 1274 36 and/or and/or CC cord-010092-uftc8inx 1274 37 slow slow JJ cord-010092-uftc8inx 1274 38 recovery recovery NN cord-010092-uftc8inx 1274 39 of of IN cord-010092-uftc8inx 1274 40 their -PRON- PRP$ cord-010092-uftc8inx 1274 41 Hb Hb NNP cord-010092-uftc8inx 1274 42 level level NN cord-010092-uftc8inx 1274 43 and and CC cord-010092-uftc8inx 1274 44 to to TO cord-010092-uftc8inx 1274 45 predict predict VB cord-010092-uftc8inx 1274 46 future future JJ cord-010092-uftc8inx 1274 47 Hb Hb NNP cord-010092-uftc8inx 1274 48 values value NNS cord-010092-uftc8inx 1274 49 . . . cord-010092-uftc8inx 1275 1 Methods method NNS cord-010092-uftc8inx 1275 2 : : : cord-010092-uftc8inx 1275 3 The the DT cord-010092-uftc8inx 1275 4 study study NN cord-010092-uftc8inx 1275 5 is be VBZ cord-010092-uftc8inx 1275 6 based base VBN cord-010092-uftc8inx 1275 7 on on IN cord-010092-uftc8inx 1275 8 data datum NNS cord-010092-uftc8inx 1275 9 of of IN cord-010092-uftc8inx 1275 10 the the DT cord-010092-uftc8inx 1275 11 Donor Donor NNP cord-010092-uftc8inx 1275 12 InSight InSight NNP cord-010092-uftc8inx 1275 13 study study NN cord-010092-uftc8inx 1275 14 , , , cord-010092-uftc8inx 1275 15 which which WDT cord-010092-uftc8inx 1275 16 was be VBD cord-010092-uftc8inx 1275 17 a a DT cord-010092-uftc8inx 1275 18 prospective prospective JJ cord-010092-uftc8inx 1275 19 cohort cohort NN cord-010092-uftc8inx 1275 20 study study NN cord-010092-uftc8inx 1275 21 performed perform VBN cord-010092-uftc8inx 1275 22 by by IN cord-010092-uftc8inx 1275 23 Sanquin Sanquin NNP cord-010092-uftc8inx 1275 24 in in IN cord-010092-uftc8inx 1275 25 the the DT cord-010092-uftc8inx 1275 26 Netherlands Netherlands NNP cord-010092-uftc8inx 1275 27 from from IN cord-010092-uftc8inx 1275 28 2007 2007 CD cord-010092-uftc8inx 1275 29 to to IN cord-010092-uftc8inx 1275 30 2016 2016 CD cord-010092-uftc8inx 1275 31 . . . cord-010092-uftc8inx 1276 1 We -PRON- PRP cord-010092-uftc8inx 1276 2 employed employ VBD cord-010092-uftc8inx 1276 3 three three CD cord-010092-uftc8inx 1276 4 statistical statistical JJ cord-010092-uftc8inx 1276 5 models model NNS cord-010092-uftc8inx 1276 6 for for IN cord-010092-uftc8inx 1276 7 the the DT cord-010092-uftc8inx 1276 8 Hb Hb NNP cord-010092-uftc8inx 1276 9 value value NN cord-010092-uftc8inx 1276 10 : : : cord-010092-uftc8inx 1276 11 ( ( -LRB- cord-010092-uftc8inx 1276 12 i i NN cord-010092-uftc8inx 1276 13 ) ) -RRB- cord-010092-uftc8inx 1277 1 a a DT cord-010092-uftc8inx 1277 2 mixed mixed JJ cord-010092-uftc8inx 1277 3 - - HYPH cord-010092-uftc8inx 1277 4 effects effect NNS cord-010092-uftc8inx 1277 5 models model NNS cord-010092-uftc8inx 1277 6 , , , cord-010092-uftc8inx 1277 7 ( ( -LRB- cord-010092-uftc8inx 1277 8 ii ii NN cord-010092-uftc8inx 1277 9 ) ) -RRB- cord-010092-uftc8inx 1277 10 a a DT cord-010092-uftc8inx 1277 11 latent latent JJ cord-010092-uftc8inx 1277 12 - - HYPH cord-010092-uftc8inx 1277 13 class class NN cord-010092-uftc8inx 1277 14 mixed mixed JJ cord-010092-uftc8inx 1277 15 effects effect NNS cord-010092-uftc8inx 1277 16 model model NN cord-010092-uftc8inx 1277 17 , , , cord-010092-uftc8inx 1277 18 and and CC cord-010092-uftc8inx 1277 19 ( ( -LRB- cord-010092-uftc8inx 1277 20 iii iii NN cord-010092-uftc8inx 1277 21 ) ) -RRB- cord-010092-uftc8inx 1277 22 a a DT cord-010092-uftc8inx 1277 23 latent latent JJ cord-010092-uftc8inx 1277 24 - - HYPH cord-010092-uftc8inx 1277 25 class class NN cord-010092-uftc8inx 1277 26 mixed mixed JJ cord-010092-uftc8inx 1277 27 - - HYPH cord-010092-uftc8inx 1277 28 effects effect NNS cord-010092-uftc8inx 1277 29 transition transition NN cord-010092-uftc8inx 1277 30 model model NN cord-010092-uftc8inx 1277 31 . . . cord-010092-uftc8inx 1278 1 In in IN cord-010092-uftc8inx 1278 2 each each DT cord-010092-uftc8inx 1278 3 model model NN cord-010092-uftc8inx 1278 4 , , , cord-010092-uftc8inx 1278 5 a a DT cord-010092-uftc8inx 1278 6 flexible flexible JJ cord-010092-uftc8inx 1278 7 function function NN cord-010092-uftc8inx 1278 8 was be VBD cord-010092-uftc8inx 1278 9 used use VBN cord-010092-uftc8inx 1278 10 to to TO cord-010092-uftc8inx 1278 11 model model VB cord-010092-uftc8inx 1278 12 the the DT cord-010092-uftc8inx 1278 13 recovery recovery NN cord-010092-uftc8inx 1278 14 process process NN cord-010092-uftc8inx 1278 15 after after IN cord-010092-uftc8inx 1278 16 donation donation NN cord-010092-uftc8inx 1278 17 . . . cord-010092-uftc8inx 1279 1 The the DT cord-010092-uftc8inx 1279 2 latent latent NN cord-010092-uftc8inx 1279 3 classes class NNS cord-010092-uftc8inx 1279 4 identify identify VBP cord-010092-uftc8inx 1279 5 groups group NNS cord-010092-uftc8inx 1279 6 of of IN cord-010092-uftc8inx 1279 7 donors donor NNS cord-010092-uftc8inx 1279 8 with with IN cord-010092-uftc8inx 1279 9 fast fast JJ cord-010092-uftc8inx 1279 10 or or CC cord-010092-uftc8inx 1279 11 slow slow JJ cord-010092-uftc8inx 1279 12 recovery recovery NN cord-010092-uftc8inx 1279 13 times time NNS cord-010092-uftc8inx 1279 14 , , , cord-010092-uftc8inx 1279 15 and and CC cord-010092-uftc8inx 1279 16 donors donor NNS cord-010092-uftc8inx 1279 17 whose whose WP$ cord-010092-uftc8inx 1279 18 recovery recovery NN cord-010092-uftc8inx 1279 19 time time NN cord-010092-uftc8inx 1279 20 increases increase VBZ cord-010092-uftc8inx 1279 21 with with IN cord-010092-uftc8inx 1279 22 the the DT cord-010092-uftc8inx 1279 23 number number NN cord-010092-uftc8inx 1279 24 of of IN cord-010092-uftc8inx 1279 25 donations donation NNS cord-010092-uftc8inx 1279 26 . . . cord-010092-uftc8inx 1280 1 The the DT cord-010092-uftc8inx 1280 2 transition transition NN cord-010092-uftc8inx 1280 3 effect effect NN cord-010092-uftc8inx 1280 4 accounts account VBZ cord-010092-uftc8inx 1280 5 for for IN cord-010092-uftc8inx 1280 6 possible possible JJ cord-010092-uftc8inx 1280 7 state state NN cord-010092-uftc8inx 1280 8 dependence dependence NN cord-010092-uftc8inx 1280 9 in in IN cord-010092-uftc8inx 1280 10 the the DT cord-010092-uftc8inx 1280 11 observed observed JJ cord-010092-uftc8inx 1280 12 data datum NNS cord-010092-uftc8inx 1280 13 . . . cord-010092-uftc8inx 1281 1 All all DT cord-010092-uftc8inx 1281 2 models model NNS cord-010092-uftc8inx 1281 3 were be VBD cord-010092-uftc8inx 1281 4 estimated estimate VBN cord-010092-uftc8inx 1281 5 in in IN cord-010092-uftc8inx 1281 6 a a DT cord-010092-uftc8inx 1281 7 Bayesian bayesian JJ cord-010092-uftc8inx 1281 8 way way NN cord-010092-uftc8inx 1281 9 , , , cord-010092-uftc8inx 1281 10 using use VBG cord-010092-uftc8inx 1281 11 data datum NNS cord-010092-uftc8inx 1281 12 of of IN cord-010092-uftc8inx 1281 13 a a DT cord-010092-uftc8inx 1281 14 sample sample NN cord-010092-uftc8inx 1281 15 of of IN cord-010092-uftc8inx 1281 16 1000 1000 CD cord-010092-uftc8inx 1281 17 new new JJ cord-010092-uftc8inx 1281 18 entrant entrant JJ cord-010092-uftc8inx 1281 19 donors donor NNS cord-010092-uftc8inx 1281 20 ( ( -LRB- cord-010092-uftc8inx 1281 21 500 500 CD cord-010092-uftc8inx 1281 22 males male NNS cord-010092-uftc8inx 1281 23 and and CC cord-010092-uftc8inx 1281 24 500 500 CD cord-010092-uftc8inx 1281 25 females female NNS cord-010092-uftc8inx 1281 26 ) ) -RRB- cord-010092-uftc8inx 1281 27 . . . cord-010092-uftc8inx 1282 1 Prior prior JJ cord-010092-uftc8inx 1282 2 information information NN cord-010092-uftc8inx 1282 3 from from IN cord-010092-uftc8inx 1282 4 the the DT cord-010092-uftc8inx 1282 5 clinical clinical JJ cord-010092-uftc8inx 1282 6 literature literature NN cord-010092-uftc8inx 1282 7 ( ( -LRB- cord-010092-uftc8inx 1282 8 Boulton Boulton NNP cord-010092-uftc8inx 1282 9 , , , cord-010092-uftc8inx 1282 10 Vox Vox NNP cord-010092-uftc8inx 1282 11 Sanguinis Sanguinis NNP cord-010092-uftc8inx 1282 12 2004 2004 CD cord-010092-uftc8inx 1282 13 ) ) -RRB- cord-010092-uftc8inx 1282 14 about about IN cord-010092-uftc8inx 1282 15 the the DT cord-010092-uftc8inx 1282 16 recovery recovery NN cord-010092-uftc8inx 1282 17 process process NN cord-010092-uftc8inx 1282 18 three three CD cord-010092-uftc8inx 1282 19 days day NNS cord-010092-uftc8inx 1282 20 after after IN cord-010092-uftc8inx 1282 21 blood blood NN cord-010092-uftc8inx 1282 22 donation donation NN cord-010092-uftc8inx 1282 23 was be VBD cord-010092-uftc8inx 1282 24 incorporated incorporate VBN cord-010092-uftc8inx 1282 25 into into IN cord-010092-uftc8inx 1282 26 the the DT cord-010092-uftc8inx 1282 27 analysis analysis NN cord-010092-uftc8inx 1282 28 since since IN cord-010092-uftc8inx 1282 29 these these DT cord-010092-uftc8inx 1282 30 values value NNS cord-010092-uftc8inx 1282 31 were be VBD cord-010092-uftc8inx 1282 32 not not RB cord-010092-uftc8inx 1282 33 identified identify VBN cord-010092-uftc8inx 1282 34 in in IN cord-010092-uftc8inx 1282 35 the the DT cord-010092-uftc8inx 1282 36 observed observed JJ cord-010092-uftc8inx 1282 37 data datum NNS cord-010092-uftc8inx 1282 38 . . . cord-010092-uftc8inx 1283 1 Results result NNS cord-010092-uftc8inx 1283 2 : : : cord-010092-uftc8inx 1284 1 The the DT cord-010092-uftc8inx 1284 2 results result NNS cord-010092-uftc8inx 1284 3 show show VBP cord-010092-uftc8inx 1284 4 that that IN cord-010092-uftc8inx 1284 5 the the DT cord-010092-uftc8inx 1284 6 latent latent JJ cord-010092-uftc8inx 1284 7 - - HYPH cord-010092-uftc8inx 1284 8 class class NN cord-010092-uftc8inx 1284 9 mixed mixed JJ cord-010092-uftc8inx 1284 10 - - HYPH cord-010092-uftc8inx 1284 11 effects effect NNS cord-010092-uftc8inx 1284 12 transition transition NN cord-010092-uftc8inx 1284 13 model model NN cord-010092-uftc8inx 1284 14 fits fit VBZ cord-010092-uftc8inx 1284 15 the the DT cord-010092-uftc8inx 1284 16 data datum NNS cord-010092-uftc8inx 1284 17 best best RB cord-010092-uftc8inx 1284 18 . . . cord-010092-uftc8inx 1285 1 We -PRON- PRP cord-010092-uftc8inx 1285 2 also also RB cord-010092-uftc8inx 1285 3 found find VBD cord-010092-uftc8inx 1285 4 that that IN cord-010092-uftc8inx 1285 5 the the DT cord-010092-uftc8inx 1285 6 recovery recovery NN cord-010092-uftc8inx 1285 7 process process NN cord-010092-uftc8inx 1285 8 shows show VBZ cord-010092-uftc8inx 1285 9 a a DT cord-010092-uftc8inx 1285 10 concave concave JJ cord-010092-uftc8inx 1285 11 process process NN cord-010092-uftc8inx 1285 12 ( ( -LRB- cord-010092-uftc8inx 1285 13 initially initially RB cord-010092-uftc8inx 1285 14 fast fast RB cord-010092-uftc8inx 1285 15 followed follow VBN cord-010092-uftc8inx 1285 16 by by IN cord-010092-uftc8inx 1285 17 slower slow JJR cord-010092-uftc8inx 1285 18 recovery recovery NN cord-010092-uftc8inx 1285 19 ) ) -RRB- cord-010092-uftc8inx 1285 20 . . . cord-010092-uftc8inx 1286 1 The the DT cord-010092-uftc8inx 1286 2 estimated estimate VBN cord-010092-uftc8inx 1286 3 recovery recovery NN cord-010092-uftc8inx 1286 4 time time NN cord-010092-uftc8inx 1286 5 is be VBZ cord-010092-uftc8inx 1286 6 much much RB cord-010092-uftc8inx 1286 7 longer long JJR cord-010092-uftc8inx 1286 8 than than IN cord-010092-uftc8inx 1286 9 the the DT cord-010092-uftc8inx 1286 10 current current JJ cord-010092-uftc8inx 1286 11 minimum minimum NN cord-010092-uftc8inx 1286 12 interval interval NN cord-010092-uftc8inx 1286 13 of of IN cord-010092-uftc8inx 1286 14 58 58 CD cord-010092-uftc8inx 1286 15 days day NNS cord-010092-uftc8inx 1286 16 between between IN cord-010092-uftc8inx 1286 17 donations donation NNS cord-010092-uftc8inx 1286 18 . . . cord-010092-uftc8inx 1287 1 Namely namely RB cord-010092-uftc8inx 1287 2 , , , cord-010092-uftc8inx 1287 3 depending depend VBG cord-010092-uftc8inx 1287 4 on on IN cord-010092-uftc8inx 1287 5 the the DT cord-010092-uftc8inx 1287 6 subgroup subgroup NN cord-010092-uftc8inx 1287 7 that that IN cord-010092-uftc8inx 1287 8 the the DT cord-010092-uftc8inx 1287 9 donor donor NN cord-010092-uftc8inx 1287 10 belonged belong VBD cord-010092-uftc8inx 1287 11 to to IN cord-010092-uftc8inx 1287 12 , , , cord-010092-uftc8inx 1287 13 males male NNS cord-010092-uftc8inx 1287 14 showed show VBD cord-010092-uftc8inx 1287 15 a a DT cord-010092-uftc8inx 1287 16 recovery recovery NN cord-010092-uftc8inx 1287 17 time time NN cord-010092-uftc8inx 1287 18 of of IN cord-010092-uftc8inx 1287 19 100 100 CD cord-010092-uftc8inx 1287 20 to to TO cord-010092-uftc8inx 1287 21 419 419 CD cord-010092-uftc8inx 1287 22 days day NNS cord-010092-uftc8inx 1287 23 , , , cord-010092-uftc8inx 1287 24 while while IN cord-010092-uftc8inx 1287 25 the the DT cord-010092-uftc8inx 1287 26 estimated estimate VBN cord-010092-uftc8inx 1287 27 recovery recovery NN cord-010092-uftc8inx 1287 28 time time NN cord-010092-uftc8inx 1287 29 for for IN cord-010092-uftc8inx 1287 30 females female NNS cord-010092-uftc8inx 1287 31 varies vary VBZ cord-010092-uftc8inx 1287 32 between between IN cord-010092-uftc8inx 1287 33 54 54 CD cord-010092-uftc8inx 1287 34 to to TO cord-010092-uftc8inx 1287 35 503 503 CD cord-010092-uftc8inx 1287 36 days day NNS cord-010092-uftc8inx 1287 37 . . . cord-010092-uftc8inx 1288 1 These these DT cord-010092-uftc8inx 1288 2 results result NNS cord-010092-uftc8inx 1288 3 suggest suggest VBP cord-010092-uftc8inx 1288 4 that that IN cord-010092-uftc8inx 1288 5 an an DT cord-010092-uftc8inx 1288 6 increase increase NN cord-010092-uftc8inx 1288 7 of of IN cord-010092-uftc8inx 1288 8 this this DT cord-010092-uftc8inx 1288 9 interval interval NN cord-010092-uftc8inx 1288 10 may may MD cord-010092-uftc8inx 1288 11 be be VB cord-010092-uftc8inx 1288 12 warranted warrant VBN cord-010092-uftc8inx 1288 13 . . . cord-010092-uftc8inx 1289 1 Summary Summary NNP cord-010092-uftc8inx 1289 2 / / SYM cord-010092-uftc8inx 1289 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 1289 4 : : : cord-010092-uftc8inx 1290 1 The the DT cord-010092-uftc8inx 1290 2 analysis analysis NN cord-010092-uftc8inx 1290 3 shows show VBZ cord-010092-uftc8inx 1290 4 the the DT cord-010092-uftc8inx 1290 5 usefulness usefulness NN cord-010092-uftc8inx 1290 6 of of IN cord-010092-uftc8inx 1290 7 the the DT cord-010092-uftc8inx 1290 8 sophisticated sophisticated JJ cord-010092-uftc8inx 1290 9 statistical statistical JJ cord-010092-uftc8inx 1290 10 models model NNS cord-010092-uftc8inx 1290 11 that that WDT cord-010092-uftc8inx 1290 12 make make VBP cord-010092-uftc8inx 1290 13 use use NN cord-010092-uftc8inx 1290 14 of of IN cord-010092-uftc8inx 1290 15 historical historical JJ cord-010092-uftc8inx 1290 16 information information NN cord-010092-uftc8inx 1290 17 to to TO cord-010092-uftc8inx 1290 18 model model VB cord-010092-uftc8inx 1290 19 complex complex JJ cord-010092-uftc8inx 1290 20 processes process NNS cord-010092-uftc8inx 1290 21 in in IN cord-010092-uftc8inx 1290 22 time time NN cord-010092-uftc8inx 1290 23 , , , cord-010092-uftc8inx 1290 24 in in IN cord-010092-uftc8inx 1290 25 this this DT cord-010092-uftc8inx 1290 26 case case NN cord-010092-uftc8inx 1290 27 the the DT cord-010092-uftc8inx 1290 28 Hb Hb NNP cord-010092-uftc8inx 1290 29 trajectory trajectory NN cord-010092-uftc8inx 1290 30 over over IN cord-010092-uftc8inx 1290 31 time time NN cord-010092-uftc8inx 1290 32 across across IN cord-010092-uftc8inx 1290 33 repeated repeat VBN cord-010092-uftc8inx 1290 34 donations donation NNS cord-010092-uftc8inx 1290 35 . . . cord-010092-uftc8inx 1291 1 In in IN cord-010092-uftc8inx 1291 2 addition addition NN cord-010092-uftc8inx 1291 3 , , , cord-010092-uftc8inx 1291 4 our -PRON- PRP$ cord-010092-uftc8inx 1291 5 results result NNS cord-010092-uftc8inx 1291 6 suggest suggest VBP cord-010092-uftc8inx 1291 7 a a DT cord-010092-uftc8inx 1291 8 ( ( -LRB- cord-010092-uftc8inx 1291 9 much much JJ cord-010092-uftc8inx 1291 10 ) ) -RRB- cord-010092-uftc8inx 1291 11 longer long JJR cord-010092-uftc8inx 1291 12 time time NN cord-010092-uftc8inx 1291 13 lag lag NN cord-010092-uftc8inx 1291 14 between between IN cord-010092-uftc8inx 1291 15 subsequent subsequent JJ cord-010092-uftc8inx 1291 16 donations donation NNS cord-010092-uftc8inx 1291 17 to to TO cord-010092-uftc8inx 1291 18 avoid avoid VB cord-010092-uftc8inx 1291 19 anemia anemia NN cord-010092-uftc8inx 1291 20 . . . cord-010092-uftc8inx 1292 1 Background background NN cord-010092-uftc8inx 1292 2 : : : cord-010092-uftc8inx 1293 1 Complications complication NNS cord-010092-uftc8inx 1293 2 of of IN cord-010092-uftc8inx 1293 3 blood blood NN cord-010092-uftc8inx 1293 4 donation donation NN cord-010092-uftc8inx 1293 5 are be VBP cord-010092-uftc8inx 1293 6 known know VBN cord-010092-uftc8inx 1293 7 to to TO cord-010092-uftc8inx 1293 8 reduce reduce VB cord-010092-uftc8inx 1293 9 donors donor NNS cord-010092-uftc8inx 1293 10 ' ' POS cord-010092-uftc8inx 1293 11 return return NN cord-010092-uftc8inx 1293 12 for for IN cord-010092-uftc8inx 1293 13 future future JJ cord-010092-uftc8inx 1293 14 donation donation NN cord-010092-uftc8inx 1293 15 . . . cord-010092-uftc8inx 1294 1 The the DT cord-010092-uftc8inx 1294 2 EPISoDe EPISoDe NNP cord-010092-uftc8inx 1294 3 study study NN cord-010092-uftc8inx 1294 4 ( ( -LRB- cord-010092-uftc8inx 1294 5 Experience Experience NNP cord-010092-uftc8inx 1294 6 Success Success NNP cord-010092-uftc8inx 1294 7 in in IN cord-010092-uftc8inx 1294 8 Donation Donation NNP cord-010092-uftc8inx 1294 9 ) ) -RRB- cord-010092-uftc8inx 1294 10 showed show VBD cord-010092-uftc8inx 1294 11 that that IN cord-010092-uftc8inx 1294 12 water water NN cord-010092-uftc8inx 1294 13 drinking drink VBG cord-010092-uftc8inx 1294 14 shortly shortly RB cord-010092-uftc8inx 1294 15 before before IN cord-010092-uftc8inx 1294 16 donation donation NN cord-010092-uftc8inx 1294 17 had have VBD cord-010092-uftc8inx 1294 18 an an DT cord-010092-uftc8inx 1294 19 effect effect NN cord-010092-uftc8inx 1294 20 of of IN cord-010092-uftc8inx 1294 21 23 23 CD cord-010092-uftc8inx 1294 22 % % NN cord-010092-uftc8inx 1294 23 reduction reduction NN cord-010092-uftc8inx 1294 24 of of IN cord-010092-uftc8inx 1294 25 selfreported selfreported JJ cord-010092-uftc8inx 1294 26 vasovagal vasovagal JJ cord-010092-uftc8inx 1294 27 reactions reaction NNS cord-010092-uftc8inx 1294 28 ( ( -LRB- cord-010092-uftc8inx 1294 29 VVR vvr NN cord-010092-uftc8inx 1294 30 ) ) -RRB- cord-010092-uftc8inx 1294 31 in in IN cord-010092-uftc8inx 1294 32 younger young JJR cord-010092-uftc8inx 1294 33 novice novice NN cord-010092-uftc8inx 1294 34 whole whole JJ cord-010092-uftc8inx 1294 35 blood blood NN cord-010092-uftc8inx 1294 36 donors donor NNS cord-010092-uftc8inx 1294 37 ( ( -LRB- cord-010092-uftc8inx 1294 38 Wiersum Wiersum NNP cord-010092-uftc8inx 1294 39 - - HYPH cord-010092-uftc8inx 1294 40 Osselton Osselton NNP cord-010092-uftc8inx 1294 41 , , , cord-010092-uftc8inx 1294 42 Transfusion Transfusion NNP cord-010092-uftc8inx 1294 43 , , , cord-010092-uftc8inx 1294 44 2019 2019 CD cord-010092-uftc8inx 1294 45 ) ) -RRB- cord-010092-uftc8inx 1294 46 . . . cord-010092-uftc8inx 1295 1 Aims aim VBZ cord-010092-uftc8inx 1295 2 : : : cord-010092-uftc8inx 1296 1 In in IN cord-010092-uftc8inx 1296 2 this this DT cord-010092-uftc8inx 1296 3 study study NN cord-010092-uftc8inx 1296 4 we -PRON- PRP cord-010092-uftc8inx 1296 5 analysed analyse VBD cord-010092-uftc8inx 1296 6 the the DT cord-010092-uftc8inx 1296 7 return return NN cord-010092-uftc8inx 1296 8 for for IN cord-010092-uftc8inx 1296 9 a a DT cord-010092-uftc8inx 1296 10 subsequent subsequent JJ cord-010092-uftc8inx 1296 11 donation donation NN cord-010092-uftc8inx 1296 12 of of IN cord-010092-uftc8inx 1296 13 the the DT cord-010092-uftc8inx 1296 14 donors donor NNS cord-010092-uftc8inx 1296 15 participating participate VBG cord-010092-uftc8inx 1296 16 in in IN cord-010092-uftc8inx 1296 17 the the DT cord-010092-uftc8inx 1296 18 EPISoDe EPISoDe NNP cord-010092-uftc8inx 1296 19 study study NN cord-010092-uftc8inx 1296 20 . . . cord-010092-uftc8inx 1297 1 This this DT cord-010092-uftc8inx 1297 2 was be VBD cord-010092-uftc8inx 1297 3 a a DT cord-010092-uftc8inx 1297 4 predefined predefined JJ cord-010092-uftc8inx 1297 5 secondary secondary JJ cord-010092-uftc8inx 1297 6 outcome outcome NN cord-010092-uftc8inx 1297 7 of of IN cord-010092-uftc8inx 1297 8 the the DT cord-010092-uftc8inx 1297 9 EPISoDe EPISoDe NNP cord-010092-uftc8inx 1297 10 study study NN cord-010092-uftc8inx 1297 11 . . . cord-010092-uftc8inx 1298 1 Methods method NNS cord-010092-uftc8inx 1298 2 : : : cord-010092-uftc8inx 1299 1 The the DT cord-010092-uftc8inx 1299 2 EPISoDe EPISoDe NNP cord-010092-uftc8inx 1299 3 study study NN cord-010092-uftc8inx 1299 4 was be VBD cord-010092-uftc8inx 1299 5 conducted conduct VBN cord-010092-uftc8inx 1299 6 in in IN cord-010092-uftc8inx 1299 7 young young JJ cord-010092-uftc8inx 1299 8 ( ( -LRB- cord-010092-uftc8inx 1299 9 < < NNP cord-010092-uftc8inx 1299 10 30 30 CD cord-010092-uftc8inx 1299 11 years year NNS cord-010092-uftc8inx 1299 12 ) ) -RRB- cord-010092-uftc8inx 1300 1 whole whole JJ cord-010092-uftc8inx 1300 2 blood blood NN cord-010092-uftc8inx 1300 3 donors donor NNS cord-010092-uftc8inx 1300 4 making make VBG cord-010092-uftc8inx 1300 5 their -PRON- PRP$ cord-010092-uftc8inx 1300 6 first first JJ cord-010092-uftc8inx 1300 7 , , , cord-010092-uftc8inx 1300 8 second second JJ cord-010092-uftc8inx 1300 9 , , , cord-010092-uftc8inx 1300 10 third third JJ cord-010092-uftc8inx 1300 11 or or CC cord-010092-uftc8inx 1300 12 fourth fourth JJ cord-010092-uftc8inx 1300 13 donation donation NN cord-010092-uftc8inx 1300 14 in in IN cord-010092-uftc8inx 1300 15 geographically geographically RB cord-010092-uftc8inx 1300 16 selected select VBN cord-010092-uftc8inx 1300 17 collection collection NN cord-010092-uftc8inx 1300 18 centres centre NNS cord-010092-uftc8inx 1300 19 . . . cord-010092-uftc8inx 1301 1 The the DT cord-010092-uftc8inx 1301 2 study study NN cord-010092-uftc8inx 1301 3 interventions intervention NNS cord-010092-uftc8inx 1301 4 were be VBD cord-010092-uftc8inx 1301 5 : : : cord-010092-uftc8inx 1301 6 330 330 CD cord-010092-uftc8inx 1301 7 ml ml NN cord-010092-uftc8inx 1301 8 water water NN cord-010092-uftc8inx 1301 9 drink drink NN cord-010092-uftc8inx 1301 10 , , , cord-010092-uftc8inx 1301 11 500 500 CD cord-010092-uftc8inx 1301 12 ml ml NN cord-010092-uftc8inx 1301 13 water water NN cord-010092-uftc8inx 1301 14 drink drink NN cord-010092-uftc8inx 1301 15 or or CC cord-010092-uftc8inx 1301 16 squeezing squeeze VBG cord-010092-uftc8inx 1301 17 a a DT cord-010092-uftc8inx 1301 18 ball ball NN cord-010092-uftc8inx 1301 19 ( ( -LRB- cord-010092-uftc8inx 1301 20 placebo placebo NN cord-010092-uftc8inx 1301 21 intervention intervention NN cord-010092-uftc8inx 1301 22 ) ) -RRB- cord-010092-uftc8inx 1301 23 during during IN cord-010092-uftc8inx 1301 24 the the DT cord-010092-uftc8inx 1301 25 wait wait NN cord-010092-uftc8inx 1301 26 after after IN cord-010092-uftc8inx 1301 27 the the DT cord-010092-uftc8inx 1301 28 screening screening NN cord-010092-uftc8inx 1301 29 interview interview NN cord-010092-uftc8inx 1301 30 and and CC cord-010092-uftc8inx 1301 31 before before IN cord-010092-uftc8inx 1301 32 phlebotomy phlebotomy NNP cord-010092-uftc8inx 1301 33 , , , cord-010092-uftc8inx 1301 34 and and CC cord-010092-uftc8inx 1301 35 a a DT cord-010092-uftc8inx 1301 36 control control NN cord-010092-uftc8inx 1301 37 group group NN cord-010092-uftc8inx 1301 38 without without IN cord-010092-uftc8inx 1301 39 intervention intervention NN cord-010092-uftc8inx 1301 40 . . . cord-010092-uftc8inx 1302 1 Participating participate VBG cord-010092-uftc8inx 1302 2 donors donor NNS cord-010092-uftc8inx 1302 3 were be VBD cord-010092-uftc8inx 1302 4 sent send VBN cord-010092-uftc8inx 1302 5 an an DT cord-010092-uftc8inx 1302 6 online online JJ cord-010092-uftc8inx 1302 7 questionnaire questionnaire NN cord-010092-uftc8inx 1302 8 about about IN cord-010092-uftc8inx 1302 9 their -PRON- PRP$ cord-010092-uftc8inx 1302 10 experience experience NN cord-010092-uftc8inx 1302 11 within within IN cord-010092-uftc8inx 1302 12 a a DT cord-010092-uftc8inx 1302 13 week week NN cord-010092-uftc8inx 1302 14 following follow VBG cord-010092-uftc8inx 1302 15 their -PRON- PRP$ cord-010092-uftc8inx 1302 16 donation donation NN cord-010092-uftc8inx 1302 17 attempt attempt NN cord-010092-uftc8inx 1302 18 . . . cord-010092-uftc8inx 1303 1 In in IN cord-010092-uftc8inx 1303 2 the the DT cord-010092-uftc8inx 1303 3 Netherlands Netherlands NNP cord-010092-uftc8inx 1303 4 donors donor NNS cord-010092-uftc8inx 1303 5 are be VBP cord-010092-uftc8inx 1303 6 usually usually RB cord-010092-uftc8inx 1303 7 invited invite VBN cord-010092-uftc8inx 1303 8 for for IN cord-010092-uftc8inx 1303 9 blood blood NN cord-010092-uftc8inx 1303 10 donation donation NN cord-010092-uftc8inx 1303 11 in in IN cord-010092-uftc8inx 1303 12 accordance accordance NN cord-010092-uftc8inx 1303 13 with with IN cord-010092-uftc8inx 1303 14 hospitals hospital NNS cord-010092-uftc8inx 1303 15 ' ' POS cord-010092-uftc8inx 1303 16 needs need NNS cord-010092-uftc8inx 1303 17 ; ; : cord-010092-uftc8inx 1303 18 the the DT cord-010092-uftc8inx 1303 19 aim aim NN cord-010092-uftc8inx 1303 20 is be VBZ cord-010092-uftc8inx 1303 21 to to TO cord-010092-uftc8inx 1303 22 invite invite VB cord-010092-uftc8inx 1303 23 eligible eligible JJ cord-010092-uftc8inx 1303 24 donors donor NNS cord-010092-uftc8inx 1303 25 at at IN cord-010092-uftc8inx 1303 26 least least JJS cord-010092-uftc8inx 1303 27 once once RB cord-010092-uftc8inx 1303 28 a a DT cord-010092-uftc8inx 1303 29 year year NN cord-010092-uftc8inx 1303 30 . . . cord-010092-uftc8inx 1304 1 Donors donor NNS cord-010092-uftc8inx 1304 2 were be VBD cord-010092-uftc8inx 1304 3 included include VBN cord-010092-uftc8inx 1304 4 in in IN cord-010092-uftc8inx 1304 5 the the DT cord-010092-uftc8inx 1304 6 return return NN cord-010092-uftc8inx 1304 7 analysis analysis NN cord-010092-uftc8inx 1304 8 if if IN cord-010092-uftc8inx 1304 9 they -PRON- PRP cord-010092-uftc8inx 1304 10 had have VBD cord-010092-uftc8inx 1304 11 received receive VBN cord-010092-uftc8inx 1304 12 at at IN cord-010092-uftc8inx 1304 13 least least RBS cord-010092-uftc8inx 1304 14 one one CD cord-010092-uftc8inx 1304 15 invitation invitation NN cord-010092-uftc8inx 1304 16 within within IN cord-010092-uftc8inx 1304 17 400 400 CD cord-010092-uftc8inx 1304 18 days day NNS cord-010092-uftc8inx 1304 19 after after IN cord-010092-uftc8inx 1304 20 the the DT cord-010092-uftc8inx 1304 21 index index NN cord-010092-uftc8inx 1304 22 donation donation NN cord-010092-uftc8inx 1304 23 and and CC cord-010092-uftc8inx 1304 24 we -PRON- PRP cord-010092-uftc8inx 1304 25 analysed analyse VBD cord-010092-uftc8inx 1304 26 their -PRON- PRP$ cord-010092-uftc8inx 1304 27 return return NN cord-010092-uftc8inx 1304 28 for for IN cord-010092-uftc8inx 1304 29 a a DT cord-010092-uftc8inx 1304 30 donation donation NN cord-010092-uftc8inx 1304 31 attempt attempt NN cord-010092-uftc8inx 1304 32 within within IN cord-010092-uftc8inx 1304 33 421 421 CD cord-010092-uftc8inx 1304 34 days day NNS cord-010092-uftc8inx 1304 35 . . . cord-010092-uftc8inx 1305 1 Associations association NNS cord-010092-uftc8inx 1305 2 with with IN cord-010092-uftc8inx 1305 3 the the DT cord-010092-uftc8inx 1305 4 interventions intervention NNS cord-010092-uftc8inx 1305 5 and and CC cord-010092-uftc8inx 1305 6 donors donor NNS cord-010092-uftc8inx 1305 7 ' ' POS cord-010092-uftc8inx 1305 8 donation donation NN cord-010092-uftc8inx 1305 9 status status NN cord-010092-uftc8inx 1305 10 , , , cord-010092-uftc8inx 1305 11 gender gender NN cord-010092-uftc8inx 1305 12 and and CC cord-010092-uftc8inx 1305 13 reported report VBD cord-010092-uftc8inx 1305 14 symptoms symptom NNS cord-010092-uftc8inx 1305 15 at at IN cord-010092-uftc8inx 1305 16 their -PRON- PRP$ cord-010092-uftc8inx 1305 17 index index NN cord-010092-uftc8inx 1305 18 donation donation NN cord-010092-uftc8inx 1305 19 were be VBD cord-010092-uftc8inx 1305 20 analysed analyse VBN cord-010092-uftc8inx 1305 21 by by IN cord-010092-uftc8inx 1305 22 calculating calculate VBG cord-010092-uftc8inx 1305 23 return return NN cord-010092-uftc8inx 1305 24 percentage percentage NN cord-010092-uftc8inx 1305 25 of of IN cord-010092-uftc8inx 1305 26 eligible eligible JJ cord-010092-uftc8inx 1305 27 donors donor NNS cord-010092-uftc8inx 1305 28 and and CC cord-010092-uftc8inx 1305 29 by by IN cord-010092-uftc8inx 1305 30 binomial binomial NNP cord-010092-uftc8inx 1305 31 logistic logistic JJ cord-010092-uftc8inx 1305 32 regression regression NN cord-010092-uftc8inx 1305 33 . . . cord-010092-uftc8inx 1306 1 Results result NNS cord-010092-uftc8inx 1306 2 : : : cord-010092-uftc8inx 1307 1 Out out IN cord-010092-uftc8inx 1307 2 of of IN cord-010092-uftc8inx 1307 3 the the DT cord-010092-uftc8inx 1307 4 8199 8199 CD cord-010092-uftc8inx 1307 5 EPISoDe EPISoDe NNP cord-010092-uftc8inx 1307 6 participants participant NNS cord-010092-uftc8inx 1307 7 who who WP cord-010092-uftc8inx 1307 8 had have VBD cord-010092-uftc8inx 1307 9 received receive VBN cord-010092-uftc8inx 1307 10 an an DT cord-010092-uftc8inx 1307 11 invitation invitation NN cord-010092-uftc8inx 1307 12 , , , cord-010092-uftc8inx 1307 13 6538 6538 CD cord-010092-uftc8inx 1307 14 ( ( -LRB- cord-010092-uftc8inx 1307 15 79.7 79.7 CD cord-010092-uftc8inx 1307 16 % % NN cord-010092-uftc8inx 1307 17 ) ) -RRB- cord-010092-uftc8inx 1307 18 returned return VBD cord-010092-uftc8inx 1307 19 within within IN cord-010092-uftc8inx 1307 20 the the DT cord-010092-uftc8inx 1307 21 study study NN cord-010092-uftc8inx 1307 22 period period NN cord-010092-uftc8inx 1307 23 . . . cord-010092-uftc8inx 1308 1 There there EX cord-010092-uftc8inx 1308 2 was be VBD cord-010092-uftc8inx 1308 3 no no DT cord-010092-uftc8inx 1308 4 difference difference NN cord-010092-uftc8inx 1308 5 in in IN cord-010092-uftc8inx 1308 6 donor donor NN cord-010092-uftc8inx 1308 7 return return NN cord-010092-uftc8inx 1308 8 between between IN cord-010092-uftc8inx 1308 9 the the DT cord-010092-uftc8inx 1308 10 two two CD cord-010092-uftc8inx 1308 11 water water NN cord-010092-uftc8inx 1308 12 groups group NNS cord-010092-uftc8inx 1308 13 . . . cord-010092-uftc8inx 1309 1 The the DT cord-010092-uftc8inx 1309 2 likelihood likelihood NN cord-010092-uftc8inx 1309 3 of of IN cord-010092-uftc8inx 1309 4 return return NN cord-010092-uftc8inx 1309 5 was be VBD cord-010092-uftc8inx 1309 6 significantly significantly RB cord-010092-uftc8inx 1309 7 increased increase VBN cord-010092-uftc8inx 1309 8 in in IN cord-010092-uftc8inx 1309 9 both both DT cord-010092-uftc8inx 1309 10 water water NN cord-010092-uftc8inx 1309 11 and and CC cord-010092-uftc8inx 1309 12 placebo placebo NN cord-010092-uftc8inx 1309 13 intervention intervention NN cord-010092-uftc8inx 1309 14 donors donor NNS cord-010092-uftc8inx 1309 15 compared compare VBN cord-010092-uftc8inx 1309 16 to to IN cord-010092-uftc8inx 1309 17 the the DT cord-010092-uftc8inx 1309 18 questionnaire questionnaire NN cord-010092-uftc8inx 1309 19 group group NN cord-010092-uftc8inx 1309 20 ( ( -LRB- cord-010092-uftc8inx 1309 21 OR OR NNP cord-010092-uftc8inx 1309 22 1.2 1.2 CD cord-010092-uftc8inx 1309 23 , , , cord-010092-uftc8inx 1309 24 95 95 CD cord-010092-uftc8inx 1309 25 % % NN cord-010092-uftc8inx 1309 26 CI CI NNP cord-010092-uftc8inx 1309 27 1.06 1.06 CD cord-010092-uftc8inx 1309 28 - - SYM cord-010092-uftc8inx 1309 29 1.4 1.4 CD cord-010092-uftc8inx 1309 30 and and CC cord-010092-uftc8inx 1309 31 1.3 1.3 CD cord-010092-uftc8inx 1309 32 , , , cord-010092-uftc8inx 1309 33 1.12 1.12 CD cord-010092-uftc8inx 1309 34 - - SYM cord-010092-uftc8inx 1309 35 1.5 1.5 CD cord-010092-uftc8inx 1309 36 respectively respectively RB cord-010092-uftc8inx 1309 37 ) ) -RRB- cord-010092-uftc8inx 1309 38 . . . cord-010092-uftc8inx 1310 1 Return return NN cord-010092-uftc8inx 1310 2 was be VBD cord-010092-uftc8inx 1310 3 slightly slightly RB cord-010092-uftc8inx 1310 4 lower low JJR cord-010092-uftc8inx 1310 5 in in IN cord-010092-uftc8inx 1310 6 women woman NNS cord-010092-uftc8inx 1310 7 ( ( -LRB- cord-010092-uftc8inx 1310 8 OR or CC cord-010092-uftc8inx 1310 9 0.88 0.88 CD cord-010092-uftc8inx 1310 10 , , , cord-010092-uftc8inx 1310 11 ) ) -RRB- cord-010092-uftc8inx 1310 12 and and CC cord-010092-uftc8inx 1310 13 lower low JJR cord-010092-uftc8inx 1310 14 in in IN cord-010092-uftc8inx 1310 15 first first JJ cord-010092-uftc8inx 1310 16 - - HYPH cord-010092-uftc8inx 1310 17 time time NN cord-010092-uftc8inx 1310 18 donors donor NNS cord-010092-uftc8inx 1310 19 ( ( -LRB- cord-010092-uftc8inx 1310 20 OR OR NNP cord-010092-uftc8inx 1310 21 0.86 0.86 CD cord-010092-uftc8inx 1310 22 , , , cord-010092-uftc8inx 1310 23 0.77 0.77 CD cord-010092-uftc8inx 1310 24 - - SYM cord-010092-uftc8inx 1310 25 0.96 0.96 CD cord-010092-uftc8inx 1310 26 ) ) -RRB- cord-010092-uftc8inx 1310 27 than than IN cord-010092-uftc8inx 1310 28 after after IN cord-010092-uftc8inx 1310 29 a a DT cord-010092-uftc8inx 1310 30 2 2 CD cord-010092-uftc8inx 1310 31 nd nd NN cord-010092-uftc8inx 1310 32 -4 -4 XX cord-010092-uftc8inx 1310 33 th th XX cord-010092-uftc8inx 1310 34 donation donation NN cord-010092-uftc8inx 1310 35 . . . cord-010092-uftc8inx 1311 1 A a DT cord-010092-uftc8inx 1311 2 staff staff NN cord-010092-uftc8inx 1311 3 - - HYPH cord-010092-uftc8inx 1311 4 recorded record VBN cord-010092-uftc8inx 1311 5 or or CC cord-010092-uftc8inx 1311 6 self self NN cord-010092-uftc8inx 1311 7 - - HYPH cord-010092-uftc8inx 1311 8 reported report VBN cord-010092-uftc8inx 1311 9 VVR vvr NN cord-010092-uftc8inx 1311 10 at at IN cord-010092-uftc8inx 1311 11 the the DT cord-010092-uftc8inx 1311 12 index index NN cord-010092-uftc8inx 1311 13 donation donation NN cord-010092-uftc8inx 1311 14 reduced reduce VBN cord-010092-uftc8inx 1311 15 donor donor NN cord-010092-uftc8inx 1311 16 return return NN cord-010092-uftc8inx 1311 17 ( ( -LRB- cord-010092-uftc8inx 1311 18 OR or NN cord-010092-uftc8inx 1311 19 0.47 0.47 CD cord-010092-uftc8inx 1312 1 , , , cord-010092-uftc8inx 1312 2 95 95 CD cord-010092-uftc8inx 1312 3 % % NN cord-010092-uftc8inx 1312 4 CI CI NNP cord-010092-uftc8inx 1312 5 0.37 0.37 CD cord-010092-uftc8inx 1312 6 - - SYM cord-010092-uftc8inx 1312 7 0.60 0.60 CD cord-010092-uftc8inx 1312 8 and and CC cord-010092-uftc8inx 1312 9 OR or CC cord-010092-uftc8inx 1312 10 0.53 0.53 CD cord-010092-uftc8inx 1312 11 , , , cord-010092-uftc8inx 1312 12 0.46 0.46 CD cord-010092-uftc8inx 1312 13 - - HYPH cord-010092-uftc8inx 1312 14 0.61 0.61 CD cord-010092-uftc8inx 1312 15 respectively respectively RB cord-010092-uftc8inx 1312 16 ) ) -RRB- cord-010092-uftc8inx 1312 17 . . . cord-010092-uftc8inx 1313 1 Other other JJ cord-010092-uftc8inx 1313 2 symptoms symptom NNS cord-010092-uftc8inx 1313 3 following follow VBG cord-010092-uftc8inx 1313 4 donation donation NN cord-010092-uftc8inx 1313 5 were be VBD cord-010092-uftc8inx 1313 6 also also RB cord-010092-uftc8inx 1313 7 associated associate VBN cord-010092-uftc8inx 1313 8 with with IN cord-010092-uftc8inx 1313 9 a a DT cord-010092-uftc8inx 1313 10 lower low JJR cord-010092-uftc8inx 1313 11 return return NN cord-010092-uftc8inx 1313 12 percentage percentage NN cord-010092-uftc8inx 1313 13 . . . cord-010092-uftc8inx 1314 1 Summary Summary NNP cord-010092-uftc8inx 1314 2 / / SYM cord-010092-uftc8inx 1314 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 1314 4 : : : cord-010092-uftc8inx 1315 1 In in IN cord-010092-uftc8inx 1315 2 this this DT cord-010092-uftc8inx 1315 3 cohort cohort NN cord-010092-uftc8inx 1315 4 of of IN cord-010092-uftc8inx 1315 5 younger young JJR cord-010092-uftc8inx 1315 6 new new JJ cord-010092-uftc8inx 1315 7 and and CC cord-010092-uftc8inx 1315 8 novice novice JJ cord-010092-uftc8inx 1315 9 blood blood NN cord-010092-uftc8inx 1315 10 donors donor NNS cord-010092-uftc8inx 1315 11 , , , cord-010092-uftc8inx 1315 12 79.7 79.7 CD cord-010092-uftc8inx 1315 13 % % NN cord-010092-uftc8inx 1315 14 returned return VBD cord-010092-uftc8inx 1315 15 for for IN cord-010092-uftc8inx 1315 16 a a DT cord-010092-uftc8inx 1315 17 subsequent subsequent JJ cord-010092-uftc8inx 1315 18 donation donation NN cord-010092-uftc8inx 1315 19 . . . cord-010092-uftc8inx 1316 1 A a DT cord-010092-uftc8inx 1316 2 VVR vvr NN cord-010092-uftc8inx 1316 3 ( ( -LRB- cord-010092-uftc8inx 1316 4 either either DT cord-010092-uftc8inx 1316 5 staff staff NN cord-010092-uftc8inx 1316 6 - - HYPH cord-010092-uftc8inx 1316 7 recorded record VBN cord-010092-uftc8inx 1316 8 or or CC cord-010092-uftc8inx 1316 9 selfreported selfreported JJ cord-010092-uftc8inx 1316 10 ) ) -RRB- cord-010092-uftc8inx 1316 11 reduced reduced JJ cord-010092-uftc8inx 1316 12 donor donor NN cord-010092-uftc8inx 1316 13 return return NN cord-010092-uftc8inx 1316 14 . . . cord-010092-uftc8inx 1317 1 Donors donor NNS cord-010092-uftc8inx 1317 2 who who WP cord-010092-uftc8inx 1317 3 received receive VBD cord-010092-uftc8inx 1317 4 a a DT cord-010092-uftc8inx 1317 5 study study NN cord-010092-uftc8inx 1317 6 intervention intervention NN cord-010092-uftc8inx 1317 7 , , , cord-010092-uftc8inx 1317 8 either either CC cord-010092-uftc8inx 1317 9 water water NN cord-010092-uftc8inx 1317 10 or or CC cord-010092-uftc8inx 1317 11 placebo placebo NN cord-010092-uftc8inx 1317 12 , , , cord-010092-uftc8inx 1317 13 were be VBD cord-010092-uftc8inx 1317 14 more more RBR cord-010092-uftc8inx 1317 15 likely likely JJ cord-010092-uftc8inx 1317 16 to to TO cord-010092-uftc8inx 1317 17 return return VB cord-010092-uftc8inx 1317 18 , , , cord-010092-uftc8inx 1317 19 whether whether IN cord-010092-uftc8inx 1317 20 or or CC cord-010092-uftc8inx 1317 21 not not RB cord-010092-uftc8inx 1317 22 they -PRON- PRP cord-010092-uftc8inx 1317 23 had have VBD cord-010092-uftc8inx 1317 24 suffered suffer VBN cord-010092-uftc8inx 1317 25 a a DT cord-010092-uftc8inx 1317 26 VVR vvr NN cord-010092-uftc8inx 1317 27 . . . cord-010092-uftc8inx 1318 1 It -PRON- PRP cord-010092-uftc8inx 1318 2 is be VBZ cord-010092-uftc8inx 1318 3 conceivable conceivable JJ cord-010092-uftc8inx 1318 4 that that IN cord-010092-uftc8inx 1318 5 the the DT cord-010092-uftc8inx 1318 6 mere mere JJ cord-010092-uftc8inx 1318 7 fact fact NN cord-010092-uftc8inx 1318 8 of of IN cord-010092-uftc8inx 1318 9 study study NN cord-010092-uftc8inx 1318 10 participation participation NN cord-010092-uftc8inx 1318 11 could could MD cord-010092-uftc8inx 1318 12 also also RB cord-010092-uftc8inx 1318 13 have have VB cord-010092-uftc8inx 1318 14 increased increase VBN cord-010092-uftc8inx 1318 15 donor donor NN cord-010092-uftc8inx 1318 16 return return NN cord-010092-uftc8inx 1318 17 , , , cord-010092-uftc8inx 1318 18 even even RB cord-010092-uftc8inx 1318 19 in in IN cord-010092-uftc8inx 1318 20 de de NNP cord-010092-uftc8inx 1318 21 questionnaire questionnaire NNP cord-010092-uftc8inx 1318 22 group group NN cord-010092-uftc8inx 1318 23 ; ; : cord-010092-uftc8inx 1318 24 this this DT cord-010092-uftc8inx 1318 25 will will MD cord-010092-uftc8inx 1318 26 be be VB cord-010092-uftc8inx 1318 27 examined examine VBN cord-010092-uftc8inx 1318 28 in in IN cord-010092-uftc8inx 1318 29 the the DT cord-010092-uftc8inx 1318 30 total total JJ cord-010092-uftc8inx 1318 31 population population NN cord-010092-uftc8inx 1318 32 of of IN cord-010092-uftc8inx 1318 33 target target NN cord-010092-uftc8inx 1318 34 group group NN cord-010092-uftc8inx 1318 35 donors donor NNS cord-010092-uftc8inx 1318 36 . . . cord-010092-uftc8inx 1319 1 Background background NN cord-010092-uftc8inx 1319 2 : : : cord-010092-uftc8inx 1320 1 The the DT cord-010092-uftc8inx 1320 2 contribution contribution NN cord-010092-uftc8inx 1320 3 of of IN cord-010092-uftc8inx 1320 4 older old JJR cord-010092-uftc8inx 1320 5 blood blood NN cord-010092-uftc8inx 1320 6 donors donor NNS cord-010092-uftc8inx 1320 7 to to IN cord-010092-uftc8inx 1320 8 the the DT cord-010092-uftc8inx 1320 9 blood blood NN cord-010092-uftc8inx 1320 10 supply supply NN cord-010092-uftc8inx 1320 11 is be VBZ cord-010092-uftc8inx 1320 12 substantial substantial JJ cord-010092-uftc8inx 1320 13 . . . cord-010092-uftc8inx 1321 1 In in IN cord-010092-uftc8inx 1321 2 Australia Australia NNP cord-010092-uftc8inx 1321 3 , , , cord-010092-uftc8inx 1321 4 donors donor NNS cord-010092-uftc8inx 1321 5 aged age VBN cord-010092-uftc8inx 1321 6 > > XX cord-010092-uftc8inx 1321 7 50 50 CD cord-010092-uftc8inx 1321 8 years year NNS cord-010092-uftc8inx 1321 9 contributed contribute VBD cord-010092-uftc8inx 1321 10 41 41 CD cord-010092-uftc8inx 1321 11 % % NN cord-010092-uftc8inx 1321 12 of of IN cord-010092-uftc8inx 1321 13 all all DT cord-010092-uftc8inx 1321 14 donations donation NNS cord-010092-uftc8inx 1321 15 made make VBN cord-010092-uftc8inx 1321 16 in in IN cord-010092-uftc8inx 1321 17 2017 2017 CD cord-010092-uftc8inx 1321 18 . . . cord-010092-uftc8inx 1322 1 However however RB cord-010092-uftc8inx 1322 2 , , , cord-010092-uftc8inx 1322 3 with with IN cord-010092-uftc8inx 1322 4 ageing age VBG cord-010092-uftc8inx 1322 5 , , , cord-010092-uftc8inx 1322 6 the the DT cord-010092-uftc8inx 1322 7 general general JJ cord-010092-uftc8inx 1322 8 health health NN cord-010092-uftc8inx 1322 9 status status NN cord-010092-uftc8inx 1322 10 of of IN cord-010092-uftc8inx 1322 11 older old JJR cord-010092-uftc8inx 1322 12 donors donor NNS cord-010092-uftc8inx 1322 13 changes change NNS cord-010092-uftc8inx 1322 14 relatively relatively RB cord-010092-uftc8inx 1322 15 faster fast RBR cord-010092-uftc8inx 1322 16 , , , cord-010092-uftc8inx 1322 17 thus thus RB cord-010092-uftc8inx 1322 18 progressively progressively RB cord-010092-uftc8inx 1322 19 affecting affect VBG cord-010092-uftc8inx 1322 20 their -PRON- PRP$ cord-010092-uftc8inx 1322 21 ability ability NN cord-010092-uftc8inx 1322 22 to to TO cord-010092-uftc8inx 1322 23 donate donate VB cord-010092-uftc8inx 1322 24 . . . cord-010092-uftc8inx 1323 1 An an DT cord-010092-uftc8inx 1323 2 indepth indepth JJ cord-010092-uftc8inx 1323 3 understanding understanding NN cord-010092-uftc8inx 1323 4 of of IN cord-010092-uftc8inx 1323 5 the the DT cord-010092-uftc8inx 1323 6 relationship relationship NN cord-010092-uftc8inx 1323 7 between between IN cord-010092-uftc8inx 1323 8 older old JJR cord-010092-uftc8inx 1323 9 donors donor NNS cord-010092-uftc8inx 1323 10 ' ' POS cord-010092-uftc8inx 1323 11 health health NN cord-010092-uftc8inx 1323 12 status status NN cord-010092-uftc8inx 1323 13 , , , cord-010092-uftc8inx 1323 14 future future JJ cord-010092-uftc8inx 1323 15 donation donation NN cord-010092-uftc8inx 1323 16 patterns pattern NNS cord-010092-uftc8inx 1323 17 , , , cord-010092-uftc8inx 1323 18 and and CC cord-010092-uftc8inx 1323 19 risk risk NN cord-010092-uftc8inx 1323 20 of of IN cord-010092-uftc8inx 1323 21 iron iron NN cord-010092-uftc8inx 1323 22 - - HYPH cord-010092-uftc8inx 1323 23 deficiency deficiency NN cord-010092-uftc8inx 1323 24 could could MD cord-010092-uftc8inx 1323 25 be be VB cord-010092-uftc8inx 1323 26 of of IN cord-010092-uftc8inx 1323 27 a a DT cord-010092-uftc8inx 1323 28 great great JJ cord-010092-uftc8inx 1323 29 value value NN cord-010092-uftc8inx 1323 30 to to TO cord-010092-uftc8inx 1323 31 inform inform VB cord-010092-uftc8inx 1323 32 the the DT cord-010092-uftc8inx 1323 33 Blood Blood NNP cord-010092-uftc8inx 1323 34 Service Service NNP cord-010092-uftc8inx 1323 35 to to TO cord-010092-uftc8inx 1323 36 predict predict VB cord-010092-uftc8inx 1323 37 the the DT cord-010092-uftc8inx 1323 38 number number NN cord-010092-uftc8inx 1323 39 of of IN cord-010092-uftc8inx 1323 40 future future JJ cord-010092-uftc8inx 1323 41 donations donation NNS cord-010092-uftc8inx 1323 42 , , , cord-010092-uftc8inx 1323 43 and and CC cord-010092-uftc8inx 1323 44 manage manage VB cord-010092-uftc8inx 1323 45 the the DT cord-010092-uftc8inx 1323 46 risk risk NN cord-010092-uftc8inx 1323 47 of of IN cord-010092-uftc8inx 1323 48 iron iron NN cord-010092-uftc8inx 1323 49 - - HYPH cord-010092-uftc8inx 1323 50 deficiency deficiency NN cord-010092-uftc8inx 1323 51 . . . cord-010092-uftc8inx 1324 1 Aims aim VBZ cord-010092-uftc8inx 1324 2 : : : cord-010092-uftc8inx 1325 1 To to TO cord-010092-uftc8inx 1325 2 understand understand VB cord-010092-uftc8inx 1325 3 the the DT cord-010092-uftc8inx 1325 4 relationship relationship NN cord-010092-uftc8inx 1325 5 between between IN cord-010092-uftc8inx 1325 6 self self NN cord-010092-uftc8inx 1325 7 - - HYPH cord-010092-uftc8inx 1325 8 reported report VBN cord-010092-uftc8inx 1325 9 health health NN cord-010092-uftc8inx 1325 10 , , , cord-010092-uftc8inx 1325 11 blood blood NN cord-010092-uftc8inx 1325 12 donation donation NN cord-010092-uftc8inx 1325 13 patterns pattern NNS cord-010092-uftc8inx 1325 14 , , , cord-010092-uftc8inx 1325 15 and and CC cord-010092-uftc8inx 1325 16 the the DT cord-010092-uftc8inx 1325 17 management management NN cord-010092-uftc8inx 1325 18 of of IN cord-010092-uftc8inx 1325 19 identified identify VBN cord-010092-uftc8inx 1325 20 iron iron NN cord-010092-uftc8inx 1325 21 - - HYPH cord-010092-uftc8inx 1325 22 deficiency deficiency NN cord-010092-uftc8inx 1325 23 in in IN cord-010092-uftc8inx 1325 24 older old JJR cord-010092-uftc8inx 1325 25 blood blood NN cord-010092-uftc8inx 1325 26 donors donor NNS cord-010092-uftc8inx 1325 27 . . . cord-010092-uftc8inx 1326 1 Methods method NNS cord-010092-uftc8inx 1326 2 : : : cord-010092-uftc8inx 1326 3 We -PRON- PRP cord-010092-uftc8inx 1326 4 linked link VBD cord-010092-uftc8inx 1326 5 the the DT cord-010092-uftc8inx 1326 6 Sax Sax NNP cord-010092-uftc8inx 1326 7 Institute Institute NNP cord-010092-uftc8inx 1326 8 's 's POS cord-010092-uftc8inx 1326 9 45 45 CD cord-010092-uftc8inx 1326 10 and and CC cord-010092-uftc8inx 1326 11 Up Up NNP cord-010092-uftc8inx 1326 12 study study VB cord-010092-uftc8inx 1326 13 baseline baseline JJ cord-010092-uftc8inx 1326 14 data datum NNS cord-010092-uftc8inx 1326 15 collected collect VBN cord-010092-uftc8inx 1326 16 between between IN cord-010092-uftc8inx 1326 17 2006 2006 CD cord-010092-uftc8inx 1326 18 and and CC cord-010092-uftc8inx 1326 19 2009 2009 CD cord-010092-uftc8inx 1326 20 to to IN cord-010092-uftc8inx 1326 21 the the DT cord-010092-uftc8inx 1326 22 Blood Blood NNP cord-010092-uftc8inx 1326 23 Service Service NNP cord-010092-uftc8inx 1326 24 donation donation NN cord-010092-uftc8inx 1326 25 records record NNS cord-010092-uftc8inx 1326 26 , , , cord-010092-uftc8inx 1326 27 inpatient inpatient JJ cord-010092-uftc8inx 1326 28 records record NNS cord-010092-uftc8inx 1326 29 , , , cord-010092-uftc8inx 1326 30 and and CC cord-010092-uftc8inx 1326 31 Medicare Medicare NNP cord-010092-uftc8inx 1326 32 records record NNS cord-010092-uftc8inx 1326 33 * * NFP cord-010092-uftc8inx 1326 34 . . . cord-010092-uftc8inx 1327 1 The the DT cord-010092-uftc8inx 1327 2 data data NN cord-010092-uftc8inx 1327 3 - - HYPH cord-010092-uftc8inx 1327 4 linkage linkage NN cord-010092-uftc8inx 1327 5 was be VBD cord-010092-uftc8inx 1327 6 conducted conduct VBN cord-010092-uftc8inx 1327 7 by by IN cord-010092-uftc8inx 1327 8 Centre Centre NNP cord-010092-uftc8inx 1327 9 for for IN cord-010092-uftc8inx 1327 10 Health Health NNP cord-010092-uftc8inx 1327 11 Record Record NNP cord-010092-uftc8inx 1327 12 Linkage Linkage NNP cord-010092-uftc8inx 1327 13 . . . cord-010092-uftc8inx 1328 1 Using use VBG cord-010092-uftc8inx 1328 2 these these DT cord-010092-uftc8inx 1328 3 linked link VBN cord-010092-uftc8inx 1328 4 data datum NNS cord-010092-uftc8inx 1328 5 , , , cord-010092-uftc8inx 1328 6 we -PRON- PRP cord-010092-uftc8inx 1328 7 examined examine VBD cord-010092-uftc8inx 1328 8 the the DT cord-010092-uftc8inx 1328 9 relationship relationship NN cord-010092-uftc8inx 1328 10 between between IN cord-010092-uftc8inx 1328 11 health health NN cord-010092-uftc8inx 1328 12 , , , cord-010092-uftc8inx 1328 13 donation donation NN cord-010092-uftc8inx 1328 14 patterns pattern NNS cord-010092-uftc8inx 1328 15 , , , cord-010092-uftc8inx 1328 16 and and CC cord-010092-uftc8inx 1328 17 iron iron NN cord-010092-uftc8inx 1328 18 - - HYPH cord-010092-uftc8inx 1328 19 deficiency deficiency NN cord-010092-uftc8inx 1328 20 and and CC cord-010092-uftc8inx 1328 21 its -PRON- PRP$ cord-010092-uftc8inx 1328 22 management management NN cord-010092-uftc8inx 1328 23 . . . cord-010092-uftc8inx 1329 1 Results result NNS cord-010092-uftc8inx 1329 2 : : : cord-010092-uftc8inx 1330 1 We -PRON- PRP cord-010092-uftc8inx 1330 2 followed follow VBD cord-010092-uftc8inx 1330 3 up up RP cord-010092-uftc8inx 1330 4 22,058 22,058 CD cord-010092-uftc8inx 1330 5 active active JJ cord-010092-uftc8inx 1330 6 whole whole JJ cord-010092-uftc8inx 1330 7 blood blood NN cord-010092-uftc8inx 1330 8 donors donor NNS cord-010092-uftc8inx 1330 9 for for IN cord-010092-uftc8inx 1330 10 200,403 200,403 CD cord-010092-uftc8inx 1330 11 eligible eligible JJ cord-010092-uftc8inx 1330 12 person person NN cord-010092-uftc8inx 1330 13 - - HYPH cord-010092-uftc8inx 1330 14 years year NNS cord-010092-uftc8inx 1330 15 ( ( -LRB- cord-010092-uftc8inx 1330 16 average average JJ cord-010092-uftc8inx 1330 17 age age NN cord-010092-uftc8inx 1330 18 at at IN cord-010092-uftc8inx 1330 19 recruitment recruitment NN cord-010092-uftc8inx 1330 20 56.4 56.4 CD cord-010092-uftc8inx 1330 21 years year NNS cord-010092-uftc8inx 1330 22 , , , cord-010092-uftc8inx 1330 23 56.3 56.3 CD cord-010092-uftc8inx 1330 24 % % NN cord-010092-uftc8inx 1330 25 female female JJ cord-010092-uftc8inx 1330 26 , , , cord-010092-uftc8inx 1330 27 average average JJ cord-010092-uftc8inx 1330 28 follow follow VB cord-010092-uftc8inx 1330 29 up up RB cord-010092-uftc8inx 1330 30 9.1 9.1 CD cord-010092-uftc8inx 1330 31 years year NNS cord-010092-uftc8inx 1330 32 per per IN cord-010092-uftc8inx 1330 33 - - HYPH cord-010092-uftc8inx 1330 34 person person NN cord-010092-uftc8inx 1330 35 ) ) -RRB- cord-010092-uftc8inx 1330 36 . . . cord-010092-uftc8inx 1331 1 After after IN cord-010092-uftc8inx 1331 2 adjusting adjust VBG cord-010092-uftc8inx 1331 3 for for IN cord-010092-uftc8inx 1331 4 the the DT cord-010092-uftc8inx 1331 5 effect effect NN cord-010092-uftc8inx 1331 6 of of IN cord-010092-uftc8inx 1331 7 age age NN cord-010092-uftc8inx 1331 8 , , , cord-010092-uftc8inx 1331 9 sex sex NN cord-010092-uftc8inx 1331 10 , , , cord-010092-uftc8inx 1331 11 body body NN cord-010092-uftc8inx 1331 12 - - HYPH cord-010092-uftc8inx 1331 13 mass mass NN cord-010092-uftc8inx 1331 14 index index NN cord-010092-uftc8inx 1331 15 , , , cord-010092-uftc8inx 1331 16 education education NN cord-010092-uftc8inx 1331 17 , , , cord-010092-uftc8inx 1331 18 non non JJ cord-010092-uftc8inx 1331 19 - - JJ cord-010092-uftc8inx 1331 20 English english JJ cord-010092-uftc8inx 1331 21 language language NN cord-010092-uftc8inx 1331 22 spoken speak VBN cord-010092-uftc8inx 1331 23 at at IN cord-010092-uftc8inx 1331 24 home home NN cord-010092-uftc8inx 1331 25 , , , cord-010092-uftc8inx 1331 26 country country NN cord-010092-uftc8inx 1331 27 of of IN cord-010092-uftc8inx 1331 28 birth birth NN cord-010092-uftc8inx 1331 29 , , , cord-010092-uftc8inx 1331 30 smoking smoking NN cord-010092-uftc8inx 1331 31 , , , cord-010092-uftc8inx 1331 32 physical physical JJ cord-010092-uftc8inx 1331 33 activity activity NN cord-010092-uftc8inx 1331 34 , , , cord-010092-uftc8inx 1331 35 regular regular JJ cord-010092-uftc8inx 1331 36 use use NN cord-010092-uftc8inx 1331 37 of of IN cord-010092-uftc8inx 1331 38 multivitamins multivitamin NNS cord-010092-uftc8inx 1331 39 , , , cord-010092-uftc8inx 1331 40 alcohol alcohol NN cord-010092-uftc8inx 1331 41 consumption consumption NN cord-010092-uftc8inx 1331 42 at at IN cord-010092-uftc8inx 1331 43 enrolment enrolment NN cord-010092-uftc8inx 1331 44 , , , cord-010092-uftc8inx 1331 45 and and CC cord-010092-uftc8inx 1331 46 total total JJ cord-010092-uftc8inx 1331 47 number number NN cord-010092-uftc8inx 1331 48 of of IN cord-010092-uftc8inx 1331 49 whole whole JJ cord-010092-uftc8inx 1331 50 blood blood NN cord-010092-uftc8inx 1331 51 donations donation NNS cord-010092-uftc8inx 1331 52 in in IN cord-010092-uftc8inx 1331 53 the the DT cord-010092-uftc8inx 1331 54 2 2 CD cord-010092-uftc8inx 1331 55 years year NNS cord-010092-uftc8inx 1331 56 prior prior RB cord-010092-uftc8inx 1331 57 to to IN cord-010092-uftc8inx 1331 58 enrolment enrolment NN cord-010092-uftc8inx 1331 59 , , , cord-010092-uftc8inx 1331 60 participants participant NNS cord-010092-uftc8inx 1331 61 with with IN cord-010092-uftc8inx 1331 62 better well JJR cord-010092-uftc8inx 1331 63 self self NN cord-010092-uftc8inx 1331 64 - - HYPH cord-010092-uftc8inx 1331 65 reported report VBN cord-010092-uftc8inx 1331 66 health health NN cord-010092-uftc8inx 1331 67 at at IN cord-010092-uftc8inx 1331 68 recruitment recruitment NN cord-010092-uftc8inx 1331 69 showed show VBD cord-010092-uftc8inx 1331 70 significantly significantly RB cord-010092-uftc8inx 1331 71 higher high JJR cord-010092-uftc8inx 1331 72 rates rate NNS cord-010092-uftc8inx 1331 73 of of IN cord-010092-uftc8inx 1331 74 donation donation NN cord-010092-uftc8inx 1331 75 . . . cord-010092-uftc8inx 1332 1 Excellent excellent JJ cord-010092-uftc8inx 1332 2 , , , cord-010092-uftc8inx 1332 3 very very RB cord-010092-uftc8inx 1332 4 good good JJ cord-010092-uftc8inx 1332 5 , , , cord-010092-uftc8inx 1332 6 good good JJ cord-010092-uftc8inx 1332 7 , , , cord-010092-uftc8inx 1332 8 and and CC cord-010092-uftc8inx 1332 9 fair fair JJ cord-010092-uftc8inx 1332 10 / / SYM cord-010092-uftc8inx 1332 11 poor poor JJ cord-010092-uftc8inx 1332 12 health health NN cord-010092-uftc8inx 1332 13 status status NN cord-010092-uftc8inx 1332 14 donors donor NNS cord-010092-uftc8inx 1332 15 made make VBD cord-010092-uftc8inx 1332 16 1066 1066 CD cord-010092-uftc8inx 1332 17 ( ( -LRB- cord-010092-uftc8inx 1332 18 95 95 CD cord-010092-uftc8inx 1332 19 % % NN cord-010092-uftc8inx 1332 20 CI CI NNP cord-010092-uftc8inx 1332 21 1056 1056 CD cord-010092-uftc8inx 1332 22 - - HYPH cord-010092-uftc8inx 1332 23 1075 1075 CD cord-010092-uftc8inx 1332 24 ) ) -RRB- cord-010092-uftc8inx 1332 25 , , , cord-010092-uftc8inx 1332 26 987 987 CD cord-010092-uftc8inx 1332 27 ( ( -LRB- cord-010092-uftc8inx 1332 28 981 981 CD cord-010092-uftc8inx 1332 29 - - SYM cord-010092-uftc8inx 1332 30 993 993 CD cord-010092-uftc8inx 1332 31 ) ) -RRB- cord-010092-uftc8inx 1332 32 , , , cord-010092-uftc8inx 1332 33 900 900 CD cord-010092-uftc8inx 1332 34 ( ( -LRB- cord-010092-uftc8inx 1332 35 891 891 CD cord-010092-uftc8inx 1332 36 - - SYM cord-010092-uftc8inx 1332 37 909 909 CD cord-010092-uftc8inx 1332 38 ) ) -RRB- cord-010092-uftc8inx 1332 39 , , , cord-010092-uftc8inx 1332 40 and and CC cord-010092-uftc8inx 1332 41 710 710 CD cord-010092-uftc8inx 1332 42 ( ( -LRB- cord-010092-uftc8inx 1332 43 690 690 CD cord-010092-uftc8inx 1332 44 - - SYM cord-010092-uftc8inx 1332 45 730 730 CD cord-010092-uftc8inx 1332 46 ) ) -RRB- cord-010092-uftc8inx 1332 47 donations donation NNS cord-010092-uftc8inx 1332 48 per per IN cord-010092-uftc8inx 1332 49 1000 1000 CD cord-010092-uftc8inx 1332 50 person person NN cord-010092-uftc8inx 1332 51 - - HYPH cord-010092-uftc8inx 1332 52 years year NNS cord-010092-uftc8inx 1332 53 , , , cord-010092-uftc8inx 1332 54 respectively respectively RB cord-010092-uftc8inx 1332 55 . . . cord-010092-uftc8inx 1333 1 Iron iron NN cord-010092-uftc8inx 1333 2 - - HYPH cord-010092-uftc8inx 1333 3 deficiency deficiency NN cord-010092-uftc8inx 1333 4 was be VBD cord-010092-uftc8inx 1333 5 identified identify VBN cord-010092-uftc8inx 1333 6 in in IN cord-010092-uftc8inx 1333 7 8.9 8.9 CD cord-010092-uftc8inx 1333 8 % % NN cord-010092-uftc8inx 1333 9 of of IN cord-010092-uftc8inx 1333 10 donors donor NNS cord-010092-uftc8inx 1333 11 in in IN cord-010092-uftc8inx 1333 12 the the DT cord-010092-uftc8inx 1333 13 study study NN cord-010092-uftc8inx 1333 14 ( ( -LRB- cord-010092-uftc8inx 1333 15 n n NN cord-010092-uftc8inx 1333 16 = = SYM cord-010092-uftc8inx 1333 17 1964 1964 CD cord-010092-uftc8inx 1333 18 , , , cord-010092-uftc8inx 1333 19 95 95 CD cord-010092-uftc8inx 1333 20 % % NN cord-010092-uftc8inx 1333 21 CI CI NNP cord-010092-uftc8inx 1333 22 8.5 8.5 CD cord-010092-uftc8inx 1333 23 - - HYPH cord-010092-uftc8inx 1333 24 9.3 9.3 CD cord-010092-uftc8inx 1333 25 ) ) -RRB- cord-010092-uftc8inx 1333 26 . . . cord-010092-uftc8inx 1334 1 Sixty sixty CD cord-010092-uftc8inx 1334 2 percent percent NN cord-010092-uftc8inx 1334 3 of of IN cord-010092-uftc8inx 1334 4 those those DT cord-010092-uftc8inx 1334 5 with with IN cord-010092-uftc8inx 1334 6 iron iron NN cord-010092-uftc8inx 1334 7 deficiency deficiency NN cord-010092-uftc8inx 1334 8 ( ( -LRB- cord-010092-uftc8inx 1334 9 n n NN cord-010092-uftc8inx 1334 10 = = SYM cord-010092-uftc8inx 1334 11 1,175 1,175 CD cord-010092-uftc8inx 1334 12 , , , cord-010092-uftc8inx 1334 13 95 95 CD cord-010092-uftc8inx 1334 14 % % NN cord-010092-uftc8inx 1334 15 CI CI NNP cord-010092-uftc8inx 1334 16 57.6 57.6 CD cord-010092-uftc8inx 1334 17 - - HYPH cord-010092-uftc8inx 1334 18 62.0 62.0 CD cord-010092-uftc8inx 1334 19 ) ) -RRB- cord-010092-uftc8inx 1334 20 visited visit VBD cord-010092-uftc8inx 1334 21 their -PRON- PRP$ cord-010092-uftc8inx 1334 22 general general JJ cord-010092-uftc8inx 1334 23 practitioner practitioner NN cord-010092-uftc8inx 1334 24 ( ( -LRB- cord-010092-uftc8inx 1334 25 GP GP NNP cord-010092-uftc8inx 1334 26 ) ) -RRB- cord-010092-uftc8inx 1334 27 within within IN cord-010092-uftc8inx 1334 28 60 60 CD cord-010092-uftc8inx 1334 29 days day NNS cord-010092-uftc8inx 1334 30 of of IN cord-010092-uftc8inx 1334 31 the the DT cord-010092-uftc8inx 1334 32 identification identification NN cord-010092-uftc8inx 1334 33 of of IN cord-010092-uftc8inx 1334 34 irondeficiency irondeficiency NN cord-010092-uftc8inx 1334 35 , , , cord-010092-uftc8inx 1334 36 and and CC cord-010092-uftc8inx 1334 37 48.4 48.4 CD cord-010092-uftc8inx 1334 38 % % NN cord-010092-uftc8inx 1334 39 ( ( -LRB- cord-010092-uftc8inx 1334 40 95 95 CD cord-010092-uftc8inx 1334 41 % % NN cord-010092-uftc8inx 1334 42 CI CI NNP cord-010092-uftc8inx 1334 43 45.5 45.5 CD cord-010092-uftc8inx 1334 44 - - HYPH cord-010092-uftc8inx 1334 45 51.3 51.3 CD cord-010092-uftc8inx 1334 46 ) ) -RRB- cord-010092-uftc8inx 1334 47 of of IN cord-010092-uftc8inx 1334 48 those those DT cord-010092-uftc8inx 1334 49 visiting visit VBG cord-010092-uftc8inx 1334 50 GP GP NNP cord-010092-uftc8inx 1334 51 underwent undergo VBD cord-010092-uftc8inx 1334 52 further further JJ cord-010092-uftc8inx 1334 53 iron iron NN cord-010092-uftc8inx 1334 54 status status NN cord-010092-uftc8inx 1334 55 examination examination NN cord-010092-uftc8inx 1334 56 and and CC cord-010092-uftc8inx 1334 57 monitoring monitoring NN cord-010092-uftc8inx 1334 58 . . . cord-010092-uftc8inx 1335 1 After after IN cord-010092-uftc8inx 1335 2 adjusting adjust VBG cord-010092-uftc8inx 1335 3 for for IN cord-010092-uftc8inx 1335 4 several several JJ cord-010092-uftc8inx 1335 5 potential potential JJ cord-010092-uftc8inx 1335 6 confounders confounder NNS cord-010092-uftc8inx 1335 7 including include VBG cord-010092-uftc8inx 1335 8 the the DT cord-010092-uftc8inx 1335 9 total total JJ cord-010092-uftc8inx 1335 10 number number NN cord-010092-uftc8inx 1335 11 of of IN cord-010092-uftc8inx 1335 12 donations donation NNS cord-010092-uftc8inx 1335 13 made make VBN cord-010092-uftc8inx 1335 14 during during IN cord-010092-uftc8inx 1335 15 the the DT cord-010092-uftc8inx 1335 16 follow follow NN cord-010092-uftc8inx 1335 17 - - HYPH cord-010092-uftc8inx 1335 18 up up NN cord-010092-uftc8inx 1335 19 period period NN cord-010092-uftc8inx 1335 20 , , , cord-010092-uftc8inx 1335 21 excellent excellent JJ cord-010092-uftc8inx 1335 22 self self NN cord-010092-uftc8inx 1335 23 - - HYPH cord-010092-uftc8inx 1335 24 reported report VBN cord-010092-uftc8inx 1335 25 health health NN cord-010092-uftc8inx 1335 26 status status NN cord-010092-uftc8inx 1335 27 was be VBD cord-010092-uftc8inx 1335 28 independently independently RB cord-010092-uftc8inx 1335 29 associated associate VBN cord-010092-uftc8inx 1335 30 with with IN cord-010092-uftc8inx 1335 31 lower low JJR cord-010092-uftc8inx 1335 32 risk risk NN cord-010092-uftc8inx 1335 33 of of IN cord-010092-uftc8inx 1335 34 iron iron NN cord-010092-uftc8inx 1335 35 - - HYPH cord-010092-uftc8inx 1335 36 deficiency deficiency NN cord-010092-uftc8inx 1335 37 ( ( -LRB- cord-010092-uftc8inx 1335 38 p p NN cord-010092-uftc8inx 1335 39 for for IN cord-010092-uftc8inx 1335 40 trend trend NN cord-010092-uftc8inx 1335 41 = = SYM cord-010092-uftc8inx 1335 42 0.004 0.004 CD cord-010092-uftc8inx 1335 43 ) ) -RRB- cord-010092-uftc8inx 1335 44 . . . cord-010092-uftc8inx 1336 1 Summary Summary NNP cord-010092-uftc8inx 1336 2 / / SYM cord-010092-uftc8inx 1336 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 1336 4 : : : cord-010092-uftc8inx 1337 1 Information information NN cord-010092-uftc8inx 1337 2 on on IN cord-010092-uftc8inx 1337 3 self self NN cord-010092-uftc8inx 1337 4 - - HYPH cord-010092-uftc8inx 1337 5 reported report VBN cord-010092-uftc8inx 1337 6 health health NN cord-010092-uftc8inx 1337 7 status status NN cord-010092-uftc8inx 1337 8 can can MD cord-010092-uftc8inx 1337 9 be be VB cord-010092-uftc8inx 1337 10 an an DT cord-010092-uftc8inx 1337 11 effective effective JJ cord-010092-uftc8inx 1337 12 indicator indicator NN cord-010092-uftc8inx 1337 13 to to TO cord-010092-uftc8inx 1337 14 estimate estimate VB cord-010092-uftc8inx 1337 15 the the DT cord-010092-uftc8inx 1337 16 future future JJ cord-010092-uftc8inx 1337 17 donation donation NN cord-010092-uftc8inx 1337 18 yield yield NN cord-010092-uftc8inx 1337 19 of of IN cord-010092-uftc8inx 1337 20 an an DT cord-010092-uftc8inx 1337 21 older old JJR cord-010092-uftc8inx 1337 22 blood blood NN cord-010092-uftc8inx 1337 23 donor donor NN cord-010092-uftc8inx 1337 24 panel panel NN cord-010092-uftc8inx 1337 25 , , , cord-010092-uftc8inx 1337 26 and and CC cord-010092-uftc8inx 1337 27 risk risk NN cord-010092-uftc8inx 1337 28 of of IN cord-010092-uftc8inx 1337 29 developing develop VBG cord-010092-uftc8inx 1337 30 iron iron NN cord-010092-uftc8inx 1337 31 - - HYPH cord-010092-uftc8inx 1337 32 deficiency deficiency NN cord-010092-uftc8inx 1337 33 . . . cord-010092-uftc8inx 1338 1 Donors donor NNS cord-010092-uftc8inx 1338 2 with with IN cord-010092-uftc8inx 1338 3 better well JJR cord-010092-uftc8inx 1338 4 self self NN cord-010092-uftc8inx 1338 5 - - HYPH cord-010092-uftc8inx 1338 6 reported report VBN cord-010092-uftc8inx 1338 7 health health NN cord-010092-uftc8inx 1338 8 had have VBD cord-010092-uftc8inx 1338 9 a a DT cord-010092-uftc8inx 1338 10 higher high JJR cord-010092-uftc8inx 1338 11 number number NN cord-010092-uftc8inx 1338 12 of of IN cord-010092-uftc8inx 1338 13 future future JJ cord-010092-uftc8inx 1338 14 whole whole JJ cord-010092-uftc8inx 1338 15 blood blood NN cord-010092-uftc8inx 1338 16 donations donation NNS cord-010092-uftc8inx 1338 17 and and CC cord-010092-uftc8inx 1338 18 a a DT cord-010092-uftc8inx 1338 19 lower low JJR cord-010092-uftc8inx 1338 20 risk risk NN cord-010092-uftc8inx 1338 21 of of IN cord-010092-uftc8inx 1338 22 iron iron NN cord-010092-uftc8inx 1338 23 - - HYPH cord-010092-uftc8inx 1338 24 deficiency deficiency NN cord-010092-uftc8inx 1338 25 . . . cord-010092-uftc8inx 1339 1 Donors donor NNS cord-010092-uftc8inx 1339 2 referred refer VBD cord-010092-uftc8inx 1339 3 to to IN cord-010092-uftc8inx 1339 4 GPs GPs NNP cord-010092-uftc8inx 1339 5 for for IN cord-010092-uftc8inx 1339 6 management management NN cord-010092-uftc8inx 1339 7 of of IN cord-010092-uftc8inx 1339 8 their -PRON- PRP$ cord-010092-uftc8inx 1339 9 iron iron NN cord-010092-uftc8inx 1339 10 status status NN cord-010092-uftc8inx 1339 11 utilised utilise VBD cord-010092-uftc8inx 1339 12 the the DT cord-010092-uftc8inx 1339 13 health health NN cord-010092-uftc8inx 1339 14 services service NNS cord-010092-uftc8inx 1339 15 as as IN cord-010092-uftc8inx 1339 16 expected expect VBN cord-010092-uftc8inx 1339 17 , , , cord-010092-uftc8inx 1339 18 however however RB cord-010092-uftc8inx 1339 19 there there EX cord-010092-uftc8inx 1339 20 is be VBZ cord-010092-uftc8inx 1339 21 an an DT cord-010092-uftc8inx 1339 22 opportunity opportunity NN cord-010092-uftc8inx 1339 23 to to TO cord-010092-uftc8inx 1339 24 improve improve VB cord-010092-uftc8inx 1339 25 their -PRON- PRP$ cord-010092-uftc8inx 1339 26 contact contact NN cord-010092-uftc8inx 1339 27 with with IN cord-010092-uftc8inx 1339 28 their -PRON- PRP$ cord-010092-uftc8inx 1339 29 GPs gps NNS cord-010092-uftc8inx 1339 30 . . . cord-010092-uftc8inx 1340 1 * * NFP cord-010092-uftc8inx 1340 2 Medicare Medicare NNP cord-010092-uftc8inx 1340 3 records record NNS cord-010092-uftc8inx 1340 4 was be VBD cord-010092-uftc8inx 1340 5 provided provide VBN cord-010092-uftc8inx 1340 6 by by IN cord-010092-uftc8inx 1340 7 Australian Australian NNP cord-010092-uftc8inx 1340 8 Government Government NNP cord-010092-uftc8inx 1340 9 Department Department NNP cord-010092-uftc8inx 1340 10 of of IN cord-010092-uftc8inx 1340 11 Human Human NNP cord-010092-uftc8inx 1340 12 Services Services NNPS cord-010092-uftc8inx 1340 13 . . . cord-010092-uftc8inx 1341 1 Anaemia anaemia NN cord-010092-uftc8inx 1341 2 is be VBZ cord-010092-uftc8inx 1341 3 a a DT cord-010092-uftc8inx 1341 4 major major JJ cord-010092-uftc8inx 1341 5 public public JJ cord-010092-uftc8inx 1341 6 health health NN cord-010092-uftc8inx 1341 7 issue issue NN cord-010092-uftc8inx 1341 8 , , , cord-010092-uftc8inx 1341 9 affecting affect VBG cord-010092-uftc8inx 1341 10 25 25 CD cord-010092-uftc8inx 1341 11 % % NN cord-010092-uftc8inx 1341 12 of of IN cord-010092-uftc8inx 1341 13 the the DT cord-010092-uftc8inx 1341 14 population population NN cord-010092-uftc8inx 1341 15 worldwide worldwide RB cord-010092-uftc8inx 1341 16 according accord VBG cord-010092-uftc8inx 1341 17 to to IN cord-010092-uftc8inx 1341 18 the the DT cord-010092-uftc8inx 1341 19 World World NNP cord-010092-uftc8inx 1341 20 Health Health NNP cord-010092-uftc8inx 1341 21 Organization Organization NNP cord-010092-uftc8inx 1341 22 . . . cord-010092-uftc8inx 1342 1 Iron iron NN cord-010092-uftc8inx 1342 2 deficiency deficiency NN cord-010092-uftc8inx 1342 3 is be VBZ cord-010092-uftc8inx 1342 4 responsible responsible JJ cord-010092-uftc8inx 1342 5 for for IN cord-010092-uftc8inx 1342 6 approximately approximately RB cord-010092-uftc8inx 1342 7 half half NN cord-010092-uftc8inx 1342 8 of of IN cord-010092-uftc8inx 1342 9 all all DT cord-010092-uftc8inx 1342 10 cases case NNS cord-010092-uftc8inx 1342 11 globally globally RB cord-010092-uftc8inx 1342 12 , , , cord-010092-uftc8inx 1342 13 with with IN cord-010092-uftc8inx 1342 14 other other JJ cord-010092-uftc8inx 1342 15 causes cause NNS cord-010092-uftc8inx 1342 16 including include VBG cord-010092-uftc8inx 1342 17 anaemia anaemia NN cord-010092-uftc8inx 1342 18 of of IN cord-010092-uftc8inx 1342 19 chronic chronic JJ cord-010092-uftc8inx 1342 20 disease disease NN cord-010092-uftc8inx 1342 21 , , , cord-010092-uftc8inx 1342 22 other other JJ cord-010092-uftc8inx 1342 23 nutritional nutritional JJ cord-010092-uftc8inx 1342 24 deficiencies deficiency NNS cord-010092-uftc8inx 1342 25 , , , cord-010092-uftc8inx 1342 26 haemoglobinopathies haemoglobinopathy NNS cord-010092-uftc8inx 1342 27 , , , cord-010092-uftc8inx 1342 28 renal renal JJ cord-010092-uftc8inx 1342 29 impairment impairment NN cord-010092-uftc8inx 1342 30 , , , cord-010092-uftc8inx 1342 31 malignancy malignancy NN cord-010092-uftc8inx 1342 32 and and CC cord-010092-uftc8inx 1342 33 bone bone NN cord-010092-uftc8inx 1342 34 marrow marrow NN cord-010092-uftc8inx 1342 35 disease disease NN cord-010092-uftc8inx 1342 36 . . . cord-010092-uftc8inx 1343 1 In in IN cord-010092-uftc8inx 1343 2 the the DT cord-010092-uftc8inx 1343 3 elderly elderly JJ cord-010092-uftc8inx 1343 4 , , , cord-010092-uftc8inx 1343 5 where where WRB cord-010092-uftc8inx 1343 6 anaemia anaemia NN cord-010092-uftc8inx 1343 7 is be VBZ cord-010092-uftc8inx 1343 8 even even RB cord-010092-uftc8inx 1343 9 more more RBR cord-010092-uftc8inx 1343 10 common common JJ cord-010092-uftc8inx 1343 11 , , , cord-010092-uftc8inx 1343 12 the the DT cord-010092-uftc8inx 1343 13 cause cause NN cord-010092-uftc8inx 1343 14 is be VBZ cord-010092-uftc8inx 1343 15 frequently frequently RB cord-010092-uftc8inx 1343 16 multifactorial multifactorial JJ cord-010092-uftc8inx 1343 17 . . . cord-010092-uftc8inx 1344 1 Anaemia anaemia NN cord-010092-uftc8inx 1344 2 is be VBZ cord-010092-uftc8inx 1344 3 associated associate VBN cord-010092-uftc8inx 1344 4 with with IN cord-010092-uftc8inx 1344 5 increased increase VBN cord-010092-uftc8inx 1344 6 mortality mortality NN cord-010092-uftc8inx 1344 7 , , , cord-010092-uftc8inx 1344 8 decreased decrease VBD cord-010092-uftc8inx 1344 9 cognitive cognitive JJ cord-010092-uftc8inx 1344 10 and and CC cord-010092-uftc8inx 1344 11 physical physical JJ cord-010092-uftc8inx 1344 12 function function NN cord-010092-uftc8inx 1344 13 , , , cord-010092-uftc8inx 1344 14 depressive depressive JJ cord-010092-uftc8inx 1344 15 symptoms symptom NNS cord-010092-uftc8inx 1344 16 and and CC cord-010092-uftc8inx 1344 17 fatigue fatigue NN cord-010092-uftc8inx 1344 18 , , , cord-010092-uftc8inx 1344 19 particularly particularly RB cord-010092-uftc8inx 1344 20 in in IN cord-010092-uftc8inx 1344 21 older old JJR cord-010092-uftc8inx 1344 22 adults adult NNS cord-010092-uftc8inx 1344 23 . . . cord-010092-uftc8inx 1345 1 Poor poor JJ cord-010092-uftc8inx 1345 2 outcomes outcome NNS cord-010092-uftc8inx 1345 3 have have VBP cord-010092-uftc8inx 1345 4 also also RB cord-010092-uftc8inx 1345 5 been be VBN cord-010092-uftc8inx 1345 6 reported report VBN cord-010092-uftc8inx 1345 7 in in IN cord-010092-uftc8inx 1345 8 anaemic anaemic JJ cord-010092-uftc8inx 1345 9 patients patient NNS cord-010092-uftc8inx 1345 10 with with IN cord-010092-uftc8inx 1345 11 underlying underlying JJ cord-010092-uftc8inx 1345 12 comorbidities comorbiditie NNS cord-010092-uftc8inx 1345 13 such such JJ cord-010092-uftc8inx 1345 14 as as IN cord-010092-uftc8inx 1345 15 cardiac cardiac JJ cord-010092-uftc8inx 1345 16 and and CC cord-010092-uftc8inx 1345 17 renal renal JJ cord-010092-uftc8inx 1345 18 disease disease NN cord-010092-uftc8inx 1345 19 , , , cord-010092-uftc8inx 1345 20 and and CC cord-010092-uftc8inx 1345 21 cancer cancer NN cord-010092-uftc8inx 1345 22 . . . cord-010092-uftc8inx 1346 1 Within within IN cord-010092-uftc8inx 1346 2 a a DT cord-010092-uftc8inx 1346 3 hospital hospital NN cord-010092-uftc8inx 1346 4 setting setting NN cord-010092-uftc8inx 1346 5 , , , cord-010092-uftc8inx 1346 6 anaemia anaemia NN cord-010092-uftc8inx 1346 7 is be VBZ cord-010092-uftc8inx 1346 8 highly highly RB cord-010092-uftc8inx 1346 9 prevalent prevalent JJ cord-010092-uftc8inx 1346 10 . . . cord-010092-uftc8inx 1347 1 Preoperative Preoperative NNP cord-010092-uftc8inx 1347 2 anaemia anaemia NN cord-010092-uftc8inx 1347 3 , , , cord-010092-uftc8inx 1347 4 affecting affect VBG cord-010092-uftc8inx 1347 5 up up IN cord-010092-uftc8inx 1347 6 to to TO cord-010092-uftc8inx 1347 7 30 30 CD cord-010092-uftc8inx 1347 8 % % NN cord-010092-uftc8inx 1347 9 of of IN cord-010092-uftc8inx 1347 10 patients patient NNS cord-010092-uftc8inx 1347 11 , , , cord-010092-uftc8inx 1347 12 is be VBZ cord-010092-uftc8inx 1347 13 associated associate VBN cord-010092-uftc8inx 1347 14 with with IN cord-010092-uftc8inx 1347 15 poor poor JJ cord-010092-uftc8inx 1347 16 clinical clinical JJ cord-010092-uftc8inx 1347 17 outcomes outcome NNS cord-010092-uftc8inx 1347 18 including include VBG cord-010092-uftc8inx 1347 19 higher high JJR cord-010092-uftc8inx 1347 20 in in IN cord-010092-uftc8inx 1347 21 - - HYPH cord-010092-uftc8inx 1347 22 hospital hospital NN cord-010092-uftc8inx 1347 23 mortality mortality NN cord-010092-uftc8inx 1347 24 , , , cord-010092-uftc8inx 1347 25 longer long JJR cord-010092-uftc8inx 1347 26 length length NN cord-010092-uftc8inx 1347 27 of of IN cord-010092-uftc8inx 1347 28 stay stay NN cord-010092-uftc8inx 1347 29 and and CC cord-010092-uftc8inx 1347 30 higher high JJR cord-010092-uftc8inx 1347 31 ICU ICU NNP cord-010092-uftc8inx 1347 32 admission admission NN cord-010092-uftc8inx 1347 33 rates rate NNS cord-010092-uftc8inx 1347 34 . . . cord-010092-uftc8inx 1348 1 Anaemia anaemia NN cord-010092-uftc8inx 1348 2 management management NN cord-010092-uftc8inx 1348 3 requires require VBZ cord-010092-uftc8inx 1348 4 a a DT cord-010092-uftc8inx 1348 5 proactive proactive JJ cord-010092-uftc8inx 1348 6 and and CC cord-010092-uftc8inx 1348 7 multi multi JJ cord-010092-uftc8inx 1348 8 - - JJ cord-010092-uftc8inx 1348 9 faceted faceted JJ cord-010092-uftc8inx 1348 10 approach approach NN cord-010092-uftc8inx 1348 11 , , , cord-010092-uftc8inx 1348 12 typically typically RB cord-010092-uftc8inx 1348 13 involving involve VBG cord-010092-uftc8inx 1348 14 a a DT cord-010092-uftc8inx 1348 15 multi multi JJ cord-010092-uftc8inx 1348 16 - - JJ cord-010092-uftc8inx 1348 17 disciplinary disciplinary JJ cord-010092-uftc8inx 1348 18 team team NN cord-010092-uftc8inx 1348 19 in in IN cord-010092-uftc8inx 1348 20 which which WDT cord-010092-uftc8inx 1348 21 the the DT cord-010092-uftc8inx 1348 22 transfusion transfusion NN cord-010092-uftc8inx 1348 23 practitioner practitioner NN cord-010092-uftc8inx 1348 24 plays play VBZ cord-010092-uftc8inx 1348 25 a a DT cord-010092-uftc8inx 1348 26 vital vital JJ cord-010092-uftc8inx 1348 27 role role NN cord-010092-uftc8inx 1348 28 . . . cord-010092-uftc8inx 1349 1 This this DT cord-010092-uftc8inx 1349 2 includes include VBZ cord-010092-uftc8inx 1349 3 screening screening NN cord-010092-uftc8inx 1349 4 of of IN cord-010092-uftc8inx 1349 5 high high JJ cord-010092-uftc8inx 1349 6 - - HYPH cord-010092-uftc8inx 1349 7 risk risk NN cord-010092-uftc8inx 1349 8 patients patient NNS cord-010092-uftc8inx 1349 9 and and CC cord-010092-uftc8inx 1349 10 pre pre JJ cord-010092-uftc8inx 1349 11 - - JJ cord-010092-uftc8inx 1349 12 admission admission JJ cord-010092-uftc8inx 1349 13 clinics clinic NNS cord-010092-uftc8inx 1349 14 to to TO cord-010092-uftc8inx 1349 15 identify identify VB cord-010092-uftc8inx 1349 16 and and CC cord-010092-uftc8inx 1349 17 manage manage VB cord-010092-uftc8inx 1349 18 patients patient NNS cord-010092-uftc8inx 1349 19 at at IN cord-010092-uftc8inx 1349 20 high high JJ cord-010092-uftc8inx 1349 21 risk risk NN cord-010092-uftc8inx 1349 22 of of IN cord-010092-uftc8inx 1349 23 peri peri JJ cord-010092-uftc8inx 1349 24 - - HYPH cord-010092-uftc8inx 1349 25 operative operative JJ cord-010092-uftc8inx 1349 26 anaemia anaemia NN cord-010092-uftc8inx 1349 27 . . . cord-010092-uftc8inx 1350 1 Implementation implementation NN cord-010092-uftc8inx 1350 2 of of IN cord-010092-uftc8inx 1350 3 patient patient JJ cord-010092-uftc8inx 1350 4 blood blood NN cord-010092-uftc8inx 1350 5 management management NN cord-010092-uftc8inx 1351 1 ( ( -LRB- cord-010092-uftc8inx 1351 2 PBM PBM NNP cord-010092-uftc8inx 1351 3 ) ) -RRB- cord-010092-uftc8inx 1351 4 guideline guideline NN cord-010092-uftc8inx 1351 5 recommendations recommendation NNS cord-010092-uftc8inx 1351 6 has have VBZ cord-010092-uftc8inx 1351 7 been be VBN cord-010092-uftc8inx 1351 8 shown show VBN cord-010092-uftc8inx 1351 9 to to TO cord-010092-uftc8inx 1351 10 be be VB cord-010092-uftc8inx 1351 11 effective effective JJ cord-010092-uftc8inx 1351 12 to to TO cord-010092-uftc8inx 1351 13 prevent prevent VB cord-010092-uftc8inx 1351 14 and and CC cord-010092-uftc8inx 1351 15 optimally optimally RB cord-010092-uftc8inx 1351 16 manage manage VB cord-010092-uftc8inx 1351 17 anaemia anaemia NN cord-010092-uftc8inx 1351 18 within within IN cord-010092-uftc8inx 1351 19 the the DT cord-010092-uftc8inx 1351 20 community community NN cord-010092-uftc8inx 1351 21 and and CC cord-010092-uftc8inx 1351 22 hospital hospital NN cord-010092-uftc8inx 1351 23 settings setting NNS cord-010092-uftc8inx 1351 24 . . . cord-010092-uftc8inx 1352 1 The the DT cord-010092-uftc8inx 1352 2 transfusion transfusion NN cord-010092-uftc8inx 1352 3 practitioner practitioner NN cord-010092-uftc8inx 1352 4 has have VBZ cord-010092-uftc8inx 1352 5 key key JJ cord-010092-uftc8inx 1352 6 roles role NNS cord-010092-uftc8inx 1352 7 in in IN cord-010092-uftc8inx 1352 8 the the DT cord-010092-uftc8inx 1352 9 coordination coordination NN cord-010092-uftc8inx 1352 10 , , , cord-010092-uftc8inx 1352 11 monitoring monitoring NN cord-010092-uftc8inx 1352 12 and and CC cord-010092-uftc8inx 1352 13 auditing auditing NN cord-010092-uftc8inx 1352 14 of of IN cord-010092-uftc8inx 1352 15 PBM PBM NNP cord-010092-uftc8inx 1352 16 programs program NNS cord-010092-uftc8inx 1352 17 . . . cord-010092-uftc8inx 1353 1 Active active JJ cord-010092-uftc8inx 1353 2 patient patient JJ cord-010092-uftc8inx 1353 3 involvement involvement NN cord-010092-uftc8inx 1353 4 and and CC cord-010092-uftc8inx 1353 5 engagement engagement NN cord-010092-uftc8inx 1353 6 of of IN cord-010092-uftc8inx 1353 7 all all DT cord-010092-uftc8inx 1353 8 members member NNS cord-010092-uftc8inx 1353 9 of of IN cord-010092-uftc8inx 1353 10 the the DT cord-010092-uftc8inx 1353 11 multidisciplinary multidisciplinary JJ cord-010092-uftc8inx 1353 12 team team NN cord-010092-uftc8inx 1353 13 , , , cord-010092-uftc8inx 1353 14 including include VBG cord-010092-uftc8inx 1353 15 primary primary JJ cord-010092-uftc8inx 1353 16 care care NN cord-010092-uftc8inx 1353 17 clinicians clinician NNS cord-010092-uftc8inx 1353 18 , , , cord-010092-uftc8inx 1353 19 are be VBP cord-010092-uftc8inx 1353 20 also also RB cord-010092-uftc8inx 1353 21 key key JJ cord-010092-uftc8inx 1353 22 to to TO cord-010092-uftc8inx 1353 23 enhance enhance VB cord-010092-uftc8inx 1353 24 the the DT cord-010092-uftc8inx 1353 25 success success NN cord-010092-uftc8inx 1353 26 of of IN cord-010092-uftc8inx 1353 27 such such JJ cord-010092-uftc8inx 1353 28 programs program NNS cord-010092-uftc8inx 1353 29 . . . cord-010092-uftc8inx 1354 1 TP01 TP01 NNP cord-010092-uftc8inx 1354 2 - - HYPH cord-010092-uftc8inx 1354 3 02 02 CD cord-010092-uftc8inx 1354 4 _SP cord-010092-uftc8inx 1355 1 THE the DT cord-010092-uftc8inx 1355 2 ROLE role NN cord-010092-uftc8inx 1355 3 OF of IN cord-010092-uftc8inx 1355 4 THE the DT cord-010092-uftc8inx 1355 5 TRANSFUSION transfusion NN cord-010092-uftc8inx 1355 6 PRACTITIONER practitioner NN cord-010092-uftc8inx 1355 7 IN in IN cord-010092-uftc8inx 1355 8 _SP cord-010092-uftc8inx 1355 9 ANAEMIA ANAEMIA NNP cord-010092-uftc8inx 1355 10 ASSESSMENT ASSESSMENT NNP cord-010092-uftc8inx 1355 11 AND and CC cord-010092-uftc8inx 1355 12 MANAGEMENT management NN cord-010092-uftc8inx 1355 13 : : : cord-010092-uftc8inx 1355 14 PROCESSES process NNS cord-010092-uftc8inx 1355 15 , , , cord-010092-uftc8inx 1355 16 _SP cord-010092-uftc8inx 1355 17 TIPS tip NNS cord-010092-uftc8inx 1355 18 AND and CC cord-010092-uftc8inx 1355 19 RESOURCES resource NNS cord-010092-uftc8inx 1355 20 FOR for IN cord-010092-uftc8inx 1355 21 CREATING create VBG cord-010092-uftc8inx 1355 22 Background Background NNP cord-010092-uftc8inx 1355 23 : : : cord-010092-uftc8inx 1355 24 Patient patient JJ cord-010092-uftc8inx 1355 25 blood blood NN cord-010092-uftc8inx 1355 26 management management NN cord-010092-uftc8inx 1355 27 ( ( -LRB- cord-010092-uftc8inx 1355 28 PBM PBM NNP cord-010092-uftc8inx 1355 29 ) ) -RRB- cord-010092-uftc8inx 1355 30 is be VBZ cord-010092-uftc8inx 1355 31 an an DT cord-010092-uftc8inx 1355 32 evidenced evidenced JJ cord-010092-uftc8inx 1355 33 based base VBN cord-010092-uftc8inx 1355 34 integrated integrated JJ cord-010092-uftc8inx 1355 35 multi multi JJ cord-010092-uftc8inx 1355 36 - - JJ cord-010092-uftc8inx 1355 37 disciplinary disciplinary JJ cord-010092-uftc8inx 1355 38 approach approach NN cord-010092-uftc8inx 1355 39 aimed aim VBN cord-010092-uftc8inx 1355 40 to to TO cord-010092-uftc8inx 1355 41 improve improve VB cord-010092-uftc8inx 1355 42 clinical clinical JJ cord-010092-uftc8inx 1355 43 outcomes outcome NNS cord-010092-uftc8inx 1355 44 by by IN cord-010092-uftc8inx 1355 45 effectively effectively RB cord-010092-uftc8inx 1355 46 managing manage VBG cord-010092-uftc8inx 1355 47 and and CC cord-010092-uftc8inx 1355 48 conserving conserve VBG cord-010092-uftc8inx 1355 49 the the DT cord-010092-uftc8inx 1355 50 patient patient NN cord-010092-uftc8inx 1355 51 's 's POS cord-010092-uftc8inx 1355 52 own own JJ cord-010092-uftc8inx 1355 53 blood blood NN cord-010092-uftc8inx 1355 54 , , , cord-010092-uftc8inx 1355 55 thus thus RB cord-010092-uftc8inx 1355 56 reducing reduce VBG cord-010092-uftc8inx 1355 57 unnecessary unnecessary JJ cord-010092-uftc8inx 1355 58 exposure exposure NN cord-010092-uftc8inx 1355 59 to to IN cord-010092-uftc8inx 1355 60 transfusion transfusion NN cord-010092-uftc8inx 1355 61 . . . cord-010092-uftc8inx 1356 1 PBM PBM NNP cord-010092-uftc8inx 1356 2 has have VBZ cord-010092-uftc8inx 1356 3 the the DT cord-010092-uftc8inx 1356 4 patient patient NN cord-010092-uftc8inx 1356 5 as as IN cord-010092-uftc8inx 1356 6 the the DT cord-010092-uftc8inx 1356 7 central central JJ cord-010092-uftc8inx 1356 8 focus focus NN cord-010092-uftc8inx 1356 9 with with IN cord-010092-uftc8inx 1356 10 the the DT cord-010092-uftc8inx 1356 11 aim aim NN cord-010092-uftc8inx 1356 12 being be VBG cord-010092-uftc8inx 1356 13 to to TO cord-010092-uftc8inx 1356 14 improve improve VB cord-010092-uftc8inx 1356 15 their -PRON- PRP$ cord-010092-uftc8inx 1356 16 outcomes outcome NNS cord-010092-uftc8inx 1356 17 and and CC cord-010092-uftc8inx 1356 18 include include VBP cord-010092-uftc8inx 1356 19 them -PRON- PRP cord-010092-uftc8inx 1356 20 in in IN cord-010092-uftc8inx 1356 21 the the DT cord-010092-uftc8inx 1356 22 process process NN cord-010092-uftc8inx 1356 23 . . . cord-010092-uftc8inx 1357 1 PBM PBM NNP cord-010092-uftc8inx 1357 2 includes include VBZ cord-010092-uftc8inx 1357 3 three three CD cord-010092-uftc8inx 1357 4 pillars pillar NNS cord-010092-uftc8inx 1357 5 : : : cord-010092-uftc8inx 1357 6 1 1 LS cord-010092-uftc8inx 1357 7 ) ) -RRB- cord-010092-uftc8inx 1357 8 optimising optimise VBG cord-010092-uftc8inx 1357 9 the the DT cord-010092-uftc8inx 1357 10 patient patient NN cord-010092-uftc8inx 1357 11 's 's POS cord-010092-uftc8inx 1357 12 own own JJ cord-010092-uftc8inx 1357 13 blood blood NN cord-010092-uftc8inx 1357 14 , , , cord-010092-uftc8inx 1357 15 2 2 CD cord-010092-uftc8inx 1357 16 ) ) -RRB- cord-010092-uftc8inx 1357 17 minimising minimise VBG cord-010092-uftc8inx 1357 18 blood blood NN cord-010092-uftc8inx 1357 19 loss loss NN cord-010092-uftc8inx 1357 20 and and CC cord-010092-uftc8inx 1357 21 3 3 LS cord-010092-uftc8inx 1357 22 ) ) -RRB- cord-010092-uftc8inx 1357 23 optimising optimise VBG cord-010092-uftc8inx 1357 24 a a DT cord-010092-uftc8inx 1357 25 patient patient NN cord-010092-uftc8inx 1357 26 's 's POS cord-010092-uftc8inx 1357 27 physiological physiological JJ cord-010092-uftc8inx 1357 28 tolerance tolerance NN cord-010092-uftc8inx 1357 29 of of IN cord-010092-uftc8inx 1357 30 anaemia anaemia NN cord-010092-uftc8inx 1357 31 . . . cord-010092-uftc8inx 1358 1 Delayed delay VBN cord-010092-uftc8inx 1358 2 assessment assessment NN cord-010092-uftc8inx 1358 3 / / SYM cord-010092-uftc8inx 1358 4 management management NN cord-010092-uftc8inx 1358 5 of of IN cord-010092-uftc8inx 1358 6 anaemia anaemia NN cord-010092-uftc8inx 1358 7 contributes contribute VBZ cord-010092-uftc8inx 1358 8 to to IN cord-010092-uftc8inx 1358 9 increased increase VBN cord-010092-uftc8inx 1358 10 health health NN cord-010092-uftc8inx 1358 11 costs cost NNS cord-010092-uftc8inx 1358 12 and and CC cord-010092-uftc8inx 1358 13 unnecessary unnecessary JJ cord-010092-uftc8inx 1358 14 blood blood NN cord-010092-uftc8inx 1358 15 transfusions transfusion NNS cord-010092-uftc8inx 1358 16 , , , cord-010092-uftc8inx 1358 17 and and CC cord-010092-uftc8inx 1358 18 transfusion transfusion NN cord-010092-uftc8inx 1358 19 has have VBZ cord-010092-uftc8inx 1358 20 been be VBN cord-010092-uftc8inx 1358 21 recognised recognise VBN cord-010092-uftc8inx 1358 22 to to TO cord-010092-uftc8inx 1358 23 be be VB cord-010092-uftc8inx 1358 24 associated associate VBN cord-010092-uftc8inx 1358 25 with with IN cord-010092-uftc8inx 1358 26 increase increase NN cord-010092-uftc8inx 1358 27 morbidity morbidity NN cord-010092-uftc8inx 1358 28 and and CC cord-010092-uftc8inx 1358 29 mortality mortality NN cord-010092-uftc8inx 1358 30 . . . cord-010092-uftc8inx 1359 1 The the DT cord-010092-uftc8inx 1359 2 term term NN cord-010092-uftc8inx 1359 3 Transfusion Transfusion NNP cord-010092-uftc8inx 1359 4 Practitioner Practitioner NNP cord-010092-uftc8inx 1359 5 ( ( -LRB- cord-010092-uftc8inx 1359 6 TP TP NNP cord-010092-uftc8inx 1359 7 ) ) -RRB- cord-010092-uftc8inx 1359 8 includes include VBZ cord-010092-uftc8inx 1359 9 those those DT cord-010092-uftc8inx 1359 10 known know VBN cord-010092-uftc8inx 1359 11 as as IN cord-010092-uftc8inx 1359 12 transfusion transfusion NN cord-010092-uftc8inx 1359 13 nurses nurse NNS cord-010092-uftc8inx 1359 14 , , , cord-010092-uftc8inx 1359 15 transfusion transfusion NN cord-010092-uftc8inx 1359 16 safety safety NN cord-010092-uftc8inx 1359 17 officers officer NNS cord-010092-uftc8inx 1359 18 , , , cord-010092-uftc8inx 1359 19 haemovigilance haemovigilance NN cord-010092-uftc8inx 1359 20 officers officer NNS cord-010092-uftc8inx 1359 21 , , , cord-010092-uftc8inx 1359 22 or or CC cord-010092-uftc8inx 1359 23 patient patient JJ cord-010092-uftc8inx 1359 24 blood blood NN cord-010092-uftc8inx 1359 25 management management NN cord-010092-uftc8inx 1359 26 ( ( -LRB- cord-010092-uftc8inx 1359 27 PBM PBM NNP cord-010092-uftc8inx 1359 28 ) ) -RRB- cord-010092-uftc8inx 1359 29 coordinators coordinator NNS cord-010092-uftc8inx 1359 30 . . . cord-010092-uftc8inx 1360 1 A a DT cord-010092-uftc8inx 1360 2 key key JJ cord-010092-uftc8inx 1360 3 aspect aspect NN cord-010092-uftc8inx 1360 4 of of IN cord-010092-uftc8inx 1360 5 the the DT cord-010092-uftc8inx 1360 6 role role NN cord-010092-uftc8inx 1360 7 is be VBZ cord-010092-uftc8inx 1360 8 driving drive VBG cord-010092-uftc8inx 1360 9 and and CC cord-010092-uftc8inx 1360 10 influencing influence VBG cord-010092-uftc8inx 1360 11 clinical clinical JJ cord-010092-uftc8inx 1360 12 blood blood NN cord-010092-uftc8inx 1360 13 management management NN cord-010092-uftc8inx 1360 14 activities activity NNS cord-010092-uftc8inx 1360 15 to to TO cord-010092-uftc8inx 1360 16 help help VB cord-010092-uftc8inx 1360 17 align align VB cord-010092-uftc8inx 1360 18 practice practice NN cord-010092-uftc8inx 1360 19 to to IN cord-010092-uftc8inx 1360 20 internationally internationally RB cord-010092-uftc8inx 1360 21 recognised recognise VBN cord-010092-uftc8inx 1360 22 guidelines guideline NNS cord-010092-uftc8inx 1360 23 and and CC cord-010092-uftc8inx 1360 24 standards standard NNS cord-010092-uftc8inx 1360 25 , , , cord-010092-uftc8inx 1360 26 including include VBG cord-010092-uftc8inx 1360 27 PBM PBM NNP cord-010092-uftc8inx 1360 28 . . . cord-010092-uftc8inx 1361 1 Aim aim VB cord-010092-uftc8inx 1361 2 : : : cord-010092-uftc8inx 1361 3 To to TO cord-010092-uftc8inx 1361 4 demonstrate demonstrate VB cord-010092-uftc8inx 1361 5 the the DT cord-010092-uftc8inx 1361 6 TP TP NNP cord-010092-uftc8inx 1361 7 role role NN cord-010092-uftc8inx 1361 8 in in IN cord-010092-uftc8inx 1361 9 anaemia anaemia NN cord-010092-uftc8inx 1361 10 assessment assessment NN cord-010092-uftc8inx 1361 11 & & CC cord-010092-uftc8inx 1361 12 management management NN cord-010092-uftc8inx 1361 13 and and CC cord-010092-uftc8inx 1361 14 discuss discuss VB cord-010092-uftc8inx 1361 15 strategies strategy NNS cord-010092-uftc8inx 1361 16 , , , cord-010092-uftc8inx 1361 17 processes process NNS cord-010092-uftc8inx 1361 18 , , , cord-010092-uftc8inx 1361 19 tips tip NNS cord-010092-uftc8inx 1361 20 and and CC cord-010092-uftc8inx 1361 21 resources resource NNS cord-010092-uftc8inx 1361 22 for for IN cord-010092-uftc8inx 1361 23 creating create VBG cord-010092-uftc8inx 1361 24 organisational organisational JJ cord-010092-uftc8inx 1361 25 and and CC cord-010092-uftc8inx 1361 26 cultural cultural JJ cord-010092-uftc8inx 1361 27 change change NN cord-010092-uftc8inx 1361 28 to to TO cord-010092-uftc8inx 1361 29 implement implement VB cord-010092-uftc8inx 1361 30 PBM PBM NNP cord-010092-uftc8inx 1361 31 . . . cord-010092-uftc8inx 1362 1 Context context NN cord-010092-uftc8inx 1362 2 : : : cord-010092-uftc8inx 1363 1 Literature literature NN cord-010092-uftc8inx 1363 2 outlines outline VBZ cord-010092-uftc8inx 1363 3 the the DT cord-010092-uftc8inx 1363 4 importance importance NN cord-010092-uftc8inx 1363 5 of of IN cord-010092-uftc8inx 1363 6 a a DT cord-010092-uftc8inx 1363 7 multidisciplinary multidisciplinary JJ cord-010092-uftc8inx 1363 8 team team NN cord-010092-uftc8inx 1363 9 to to TO cord-010092-uftc8inx 1363 10 implement implement VB cord-010092-uftc8inx 1363 11 PBM PBM NNP cord-010092-uftc8inx 1363 12 related related JJ cord-010092-uftc8inx 1363 13 changes change NNS cord-010092-uftc8inx 1363 14 , , , cord-010092-uftc8inx 1363 15 and and CC cord-010092-uftc8inx 1363 16 TPs tp NNS cord-010092-uftc8inx 1363 17 play play VBP cord-010092-uftc8inx 1363 18 a a DT cord-010092-uftc8inx 1363 19 fundamental fundamental JJ cord-010092-uftc8inx 1363 20 role role NN cord-010092-uftc8inx 1363 21 within within IN cord-010092-uftc8inx 1363 22 these these DT cord-010092-uftc8inx 1363 23 teams team NNS cord-010092-uftc8inx 1363 24 to to TO cord-010092-uftc8inx 1363 25 support support VB cord-010092-uftc8inx 1363 26 ' ' `` cord-010092-uftc8inx 1363 27 buy buy VB cord-010092-uftc8inx 1363 28 in in RP cord-010092-uftc8inx 1363 29 ' ' '' cord-010092-uftc8inx 1363 30 . . . cord-010092-uftc8inx 1364 1 TPs tp NNS cord-010092-uftc8inx 1364 2 are be VBP cord-010092-uftc8inx 1364 3 seen see VBN cord-010092-uftc8inx 1364 4 as as IN cord-010092-uftc8inx 1364 5 enablers enabler NNS cord-010092-uftc8inx 1364 6 , , , cord-010092-uftc8inx 1364 7 pulling pull VBG cord-010092-uftc8inx 1364 8 resources resource NNS cord-010092-uftc8inx 1364 9 together together RB cord-010092-uftc8inx 1364 10 , , , cord-010092-uftc8inx 1364 11 engaging engage VBG cord-010092-uftc8inx 1364 12 with with IN cord-010092-uftc8inx 1364 13 those those DT cord-010092-uftc8inx 1364 14 involved involve VBN cord-010092-uftc8inx 1364 15 , , , cord-010092-uftc8inx 1364 16 providing provide VBG cord-010092-uftc8inx 1364 17 education education NN cord-010092-uftc8inx 1364 18 and and CC cord-010092-uftc8inx 1364 19 facilitating facilitate VBG cord-010092-uftc8inx 1364 20 change change NN cord-010092-uftc8inx 1364 21 . . . cord-010092-uftc8inx 1365 1 They -PRON- PRP cord-010092-uftc8inx 1365 2 are be VBP cord-010092-uftc8inx 1365 3 often often RB cord-010092-uftc8inx 1365 4 the the DT cord-010092-uftc8inx 1365 5 ones one NNS cord-010092-uftc8inx 1365 6 to to TO cord-010092-uftc8inx 1365 7 conduct conduct VB cord-010092-uftc8inx 1365 8 audits audits NN cord-010092-uftc8inx 1365 9 , , , cord-010092-uftc8inx 1365 10 collating collate VBG cord-010092-uftc8inx 1365 11 data datum NNS cord-010092-uftc8inx 1365 12 and and CC cord-010092-uftc8inx 1365 13 evaluating evaluate VBG cord-010092-uftc8inx 1365 14 outcomes outcome NNS cord-010092-uftc8inx 1365 15 . . . cord-010092-uftc8inx 1366 1 Approaches approach NNS cord-010092-uftc8inx 1366 2 to to TO cord-010092-uftc8inx 1366 3 implement implement VB cord-010092-uftc8inx 1366 4 PBM PBM NNP cord-010092-uftc8inx 1366 5 should should MD cord-010092-uftc8inx 1366 6 be be VB cord-010092-uftc8inx 1366 7 tailored tailor VBN cord-010092-uftc8inx 1366 8 to to TO cord-010092-uftc8inx 1366 9 suit suit VB cord-010092-uftc8inx 1366 10 individual individual JJ cord-010092-uftc8inx 1366 11 organisations organisation NNS cord-010092-uftc8inx 1366 12 . . . cord-010092-uftc8inx 1367 1 The the DT cord-010092-uftc8inx 1367 2 authors author NNS cord-010092-uftc8inx 1367 3 will will MD cord-010092-uftc8inx 1367 4 outline outline VB cord-010092-uftc8inx 1367 5 different different JJ cord-010092-uftc8inx 1367 6 approaches approach NNS cord-010092-uftc8inx 1367 7 , , , cord-010092-uftc8inx 1367 8 highlighting highlight VBG cord-010092-uftc8inx 1367 9 where where WRB cord-010092-uftc8inx 1367 10 the the DT cord-010092-uftc8inx 1367 11 TP TP NNP cord-010092-uftc8inx 1367 12 can can MD cord-010092-uftc8inx 1367 13 support support VB cord-010092-uftc8inx 1367 14 or or CC cord-010092-uftc8inx 1367 15 lead lead VB cord-010092-uftc8inx 1367 16 activities activity NNS cord-010092-uftc8inx 1367 17 . . . cord-010092-uftc8inx 1368 1 One one CD cord-010092-uftc8inx 1368 2 approach approach NN cord-010092-uftc8inx 1368 3 to to IN cord-010092-uftc8inx 1368 4 anaemia anaemia NN cord-010092-uftc8inx 1368 5 assessment assessment NN cord-010092-uftc8inx 1368 6 is be VBZ cord-010092-uftc8inx 1368 7 to to TO cord-010092-uftc8inx 1368 8 undertake undertake VB cord-010092-uftc8inx 1368 9 an an DT cord-010092-uftc8inx 1368 10 audit audit NN cord-010092-uftc8inx 1368 11 , , , cord-010092-uftc8inx 1368 12 examples example NNS cord-010092-uftc8inx 1368 13 of of IN cord-010092-uftc8inx 1368 14 available available JJ cord-010092-uftc8inx 1368 15 tools tool NNS cord-010092-uftc8inx 1368 16 will will MD cord-010092-uftc8inx 1368 17 be be VB cord-010092-uftc8inx 1368 18 shown show VBN cord-010092-uftc8inx 1368 19 . . . cord-010092-uftc8inx 1369 1 With with IN cord-010092-uftc8inx 1369 2 this this DT cord-010092-uftc8inx 1369 3 data data NN cord-010092-uftc8inx 1369 4 , , , cord-010092-uftc8inx 1369 5 the the DT cord-010092-uftc8inx 1369 6 TP tp NN cord-010092-uftc8inx 1369 7 along along RP cord-010092-uftc8inx 1369 8 with with IN cord-010092-uftc8inx 1369 9 the the DT cord-010092-uftc8inx 1369 10 PBM PBM NNP cord-010092-uftc8inx 1369 11 team team NN cord-010092-uftc8inx 1369 12 can can MD cord-010092-uftc8inx 1369 13 explore explore VB cord-010092-uftc8inx 1369 14 options option NNS cord-010092-uftc8inx 1369 15 for for IN cord-010092-uftc8inx 1369 16 corrective corrective JJ cord-010092-uftc8inx 1369 17 action action NN cord-010092-uftc8inx 1369 18 . . . cord-010092-uftc8inx 1370 1 These these DT cord-010092-uftc8inx 1370 2 could could MD cord-010092-uftc8inx 1370 3 include include VB cord-010092-uftc8inx 1370 4 interventions intervention NNS cord-010092-uftc8inx 1370 5 such such JJ cord-010092-uftc8inx 1370 6 as as IN cord-010092-uftc8inx 1370 7 developing develop VBG cord-010092-uftc8inx 1370 8 a a DT cord-010092-uftc8inx 1370 9 pathway pathway NN cord-010092-uftc8inx 1370 10 where where WRB cord-010092-uftc8inx 1370 11 all all DT cord-010092-uftc8inx 1370 12 or or CC cord-010092-uftc8inx 1370 13 a a DT cord-010092-uftc8inx 1370 14 specific specific JJ cord-010092-uftc8inx 1370 15 group group NN cord-010092-uftc8inx 1370 16 of of IN cord-010092-uftc8inx 1370 17 patients patient NNS cord-010092-uftc8inx 1370 18 are be VBP cord-010092-uftc8inx 1370 19 assessed assess VBN cord-010092-uftc8inx 1370 20 and and CC cord-010092-uftc8inx 1370 21 or or CC cord-010092-uftc8inx 1370 22 treated treat VBN cord-010092-uftc8inx 1370 23 either either CC cord-010092-uftc8inx 1370 24 at at IN cord-010092-uftc8inx 1370 25 a a DT cord-010092-uftc8inx 1370 26 preoperative preoperative JJ cord-010092-uftc8inx 1370 27 clinic clinic NN cord-010092-uftc8inx 1370 28 , , , cord-010092-uftc8inx 1370 29 or or CC cord-010092-uftc8inx 1370 30 with with IN cord-010092-uftc8inx 1370 31 their -PRON- PRP$ cord-010092-uftc8inx 1370 32 local local JJ cord-010092-uftc8inx 1370 33 general general JJ cord-010092-uftc8inx 1370 34 practitioner practitioner NN cord-010092-uftc8inx 1370 35 ; ; : cord-010092-uftc8inx 1370 36 through through IN cord-010092-uftc8inx 1370 37 to to IN cord-010092-uftc8inx 1370 38 more more RBR cord-010092-uftc8inx 1370 39 complicated complicated JJ cord-010092-uftc8inx 1370 40 strategies strategy NNS cord-010092-uftc8inx 1370 41 such such JJ cord-010092-uftc8inx 1370 42 as as IN cord-010092-uftc8inx 1370 43 establishing establish VBG cord-010092-uftc8inx 1370 44 anaemia anaemia NN cord-010092-uftc8inx 1370 45 clinics clinic NNS cord-010092-uftc8inx 1370 46 . . . cord-010092-uftc8inx 1371 1 The the DT cord-010092-uftc8inx 1371 2 skills skill NNS cord-010092-uftc8inx 1371 3 of of IN cord-010092-uftc8inx 1371 4 the the DT cord-010092-uftc8inx 1371 5 TP TP NNP cord-010092-uftc8inx 1371 6 are be VBP cord-010092-uftc8inx 1371 7 a a DT cord-010092-uftc8inx 1371 8 valuable valuable JJ cord-010092-uftc8inx 1371 9 asset asset NN cord-010092-uftc8inx 1371 10 to to TO cord-010092-uftc8inx 1371 11 analyse analyse VB cord-010092-uftc8inx 1371 12 clinical clinical JJ cord-010092-uftc8inx 1371 13 specialties specialty NNS cord-010092-uftc8inx 1371 14 / / SYM cord-010092-uftc8inx 1371 15 patient patient NN cord-010092-uftc8inx 1371 16 mix mix NN cord-010092-uftc8inx 1371 17 who who WP cord-010092-uftc8inx 1371 18 should should MD cord-010092-uftc8inx 1371 19 be be VB cord-010092-uftc8inx 1371 20 targeted target VBN cord-010092-uftc8inx 1371 21 to to TO cord-010092-uftc8inx 1371 22 achieve achieve VB cord-010092-uftc8inx 1371 23 best good JJS cord-010092-uftc8inx 1371 24 outcomes outcome NNS cord-010092-uftc8inx 1371 25 , , , cord-010092-uftc8inx 1371 26 they -PRON- PRP cord-010092-uftc8inx 1371 27 know know VBP cord-010092-uftc8inx 1371 28 the the DT cord-010092-uftc8inx 1371 29 organisation organisation NN cord-010092-uftc8inx 1371 30 and and CC cord-010092-uftc8inx 1371 31 as as IN cord-010092-uftc8inx 1371 32 such such JJ cord-010092-uftc8inx 1371 33 are be VBP cord-010092-uftc8inx 1371 34 well well RB cord-010092-uftc8inx 1371 35 placed place VBN cord-010092-uftc8inx 1371 36 to to TO cord-010092-uftc8inx 1371 37 help help VB cord-010092-uftc8inx 1371 38 develop develop VB cord-010092-uftc8inx 1371 39 a a DT cord-010092-uftc8inx 1371 40 process process NN cord-010092-uftc8inx 1371 41 / / SYM cord-010092-uftc8inx 1371 42 concept concept NN cord-010092-uftc8inx 1371 43 that that WDT cord-010092-uftc8inx 1371 44 will will MD cord-010092-uftc8inx 1371 45 suit suit VB cord-010092-uftc8inx 1371 46 , , , cord-010092-uftc8inx 1371 47 and and CC cord-010092-uftc8inx 1371 48 they -PRON- PRP cord-010092-uftc8inx 1371 49 can can MD cord-010092-uftc8inx 1371 50 provide provide VB cord-010092-uftc8inx 1371 51 education education NN cord-010092-uftc8inx 1371 52 and and CC cord-010092-uftc8inx 1371 53 support support NN cord-010092-uftc8inx 1371 54 to to TO cord-010092-uftc8inx 1371 55 promote promote VB cord-010092-uftc8inx 1371 56 and and CC cord-010092-uftc8inx 1371 57 embed embed VB cord-010092-uftc8inx 1371 58 these these DT cord-010092-uftc8inx 1371 59 practices practice NNS cord-010092-uftc8inx 1371 60 . . . cord-010092-uftc8inx 1372 1 Conclusion conclusion NN cord-010092-uftc8inx 1372 2 : : : cord-010092-uftc8inx 1373 1 Appropriate appropriate JJ cord-010092-uftc8inx 1373 2 assessment assessment NN cord-010092-uftc8inx 1373 3 and and CC cord-010092-uftc8inx 1373 4 management management NN cord-010092-uftc8inx 1373 5 of of IN cord-010092-uftc8inx 1373 6 anaemia anaemia NN cord-010092-uftc8inx 1373 7 requires require VBZ cord-010092-uftc8inx 1373 8 a a DT cord-010092-uftc8inx 1373 9 multidisciplinary multidisciplinary JJ cord-010092-uftc8inx 1373 10 approach approach NN cord-010092-uftc8inx 1373 11 . . . cord-010092-uftc8inx 1374 1 The the DT cord-010092-uftc8inx 1374 2 TP TP NNP cord-010092-uftc8inx 1374 3 plays play VBZ cord-010092-uftc8inx 1374 4 an an DT cord-010092-uftc8inx 1374 5 active active JJ cord-010092-uftc8inx 1374 6 and and CC cord-010092-uftc8inx 1374 7 crucial crucial JJ cord-010092-uftc8inx 1374 8 role role NN cord-010092-uftc8inx 1374 9 in in IN cord-010092-uftc8inx 1374 10 this this DT cord-010092-uftc8inx 1374 11 team team NN cord-010092-uftc8inx 1374 12 . . . cord-010092-uftc8inx 1375 1 Examples example NNS cord-010092-uftc8inx 1375 2 of of IN cord-010092-uftc8inx 1375 3 processes process NNS cord-010092-uftc8inx 1375 4 , , , cord-010092-uftc8inx 1375 5 tips tip NNS cord-010092-uftc8inx 1375 6 and and CC cord-010092-uftc8inx 1375 7 resources resource NNS cord-010092-uftc8inx 1375 8 to to TO cord-010092-uftc8inx 1375 9 support support VB cord-010092-uftc8inx 1375 10 change change NN cord-010092-uftc8inx 1375 11 and and CC cord-010092-uftc8inx 1375 12 embed embed VB cord-010092-uftc8inx 1375 13 a a DT cord-010092-uftc8inx 1375 14 PBM PBM NNP cord-010092-uftc8inx 1375 15 culture culture NN cord-010092-uftc8inx 1375 16 across across IN cord-010092-uftc8inx 1375 17 the the DT cord-010092-uftc8inx 1375 18 clinical clinical JJ cord-010092-uftc8inx 1375 19 spectrum spectrum NN cord-010092-uftc8inx 1375 20 will will MD cord-010092-uftc8inx 1375 21 be be VB cord-010092-uftc8inx 1375 22 shared share VBN cord-010092-uftc8inx 1375 23 . . . cord-010092-uftc8inx 1376 1 3D 3D NNP cord-010092-uftc8inx 1376 2 - - HYPH cord-010092-uftc8inx 1376 3 S11 S11 NNP cord-010092-uftc8inx 1376 4 - - HYPH cord-010092-uftc8inx 1376 5 01 01 CD cord-010092-uftc8inx 1376 6 Department Department NNP cord-010092-uftc8inx 1376 7 of of IN cord-010092-uftc8inx 1376 8 Hematology Hematology NNP cord-010092-uftc8inx 1376 9 and and CC cord-010092-uftc8inx 1376 10 Central Central NNP cord-010092-uftc8inx 1376 11 Hematology Hematology NNP cord-010092-uftc8inx 1376 12 Laboratory Laboratory NNP cord-010092-uftc8inx 1376 13 , , , cord-010092-uftc8inx 1376 14 Inselspital Inselspital NNP cord-010092-uftc8inx 1376 15 Bern Bern NNP cord-010092-uftc8inx 1376 16 , , , cord-010092-uftc8inx 1376 17 Bern Bern NNP cord-010092-uftc8inx 1376 18 , , , cord-010092-uftc8inx 1376 19 Switzerland Switzerland NNP cord-010092-uftc8inx 1376 20 Immune Immune NNP cord-010092-uftc8inx 1376 21 haemolytic haemolytic JJ cord-010092-uftc8inx 1376 22 anaemia anaemia NN cord-010092-uftc8inx 1376 23 ( ( -LRB- cord-010092-uftc8inx 1376 24 IHA IHA NNP cord-010092-uftc8inx 1376 25 ) ) -RRB- cord-010092-uftc8inx 1376 26 is be VBZ cord-010092-uftc8inx 1376 27 characterized characterize VBN cord-010092-uftc8inx 1376 28 by by IN cord-010092-uftc8inx 1376 29 an an DT cord-010092-uftc8inx 1376 30 increased increase VBN cord-010092-uftc8inx 1376 31 breakdown breakdown NN cord-010092-uftc8inx 1376 32 of of IN cord-010092-uftc8inx 1376 33 red red JJ cord-010092-uftc8inx 1376 34 blood blood NN cord-010092-uftc8inx 1376 35 cells cell NNS cord-010092-uftc8inx 1376 36 ( ( -LRB- cord-010092-uftc8inx 1376 37 RBCs rbc NNS cord-010092-uftc8inx 1376 38 ) ) -RRB- cord-010092-uftc8inx 1376 39 due due JJ cord-010092-uftc8inx 1376 40 to to IN cord-010092-uftc8inx 1376 41 allo allo NN cord-010092-uftc8inx 1376 42 - - HYPH cord-010092-uftc8inx 1376 43 and and CC cord-010092-uftc8inx 1376 44 / / SYM cord-010092-uftc8inx 1376 45 or or CC cord-010092-uftc8inx 1376 46 autoantibodies autoantibody NNS cord-010092-uftc8inx 1376 47 directed direct VBN cord-010092-uftc8inx 1376 48 to to IN cord-010092-uftc8inx 1376 49 RBC RBC NNP cord-010092-uftc8inx 1376 50 antigens antigen NNS cord-010092-uftc8inx 1376 51 with with IN cord-010092-uftc8inx 1376 52 or or CC cord-010092-uftc8inx 1376 53 without without IN cord-010092-uftc8inx 1376 54 complement complement JJ cord-010092-uftc8inx 1376 55 activation activation NN cord-010092-uftc8inx 1376 56 . . . cord-010092-uftc8inx 1377 1 Clinical clinical JJ cord-010092-uftc8inx 1377 2 and and CC cord-010092-uftc8inx 1377 3 laboratory laboratory NN cord-010092-uftc8inx 1377 4 signs sign NNS cord-010092-uftc8inx 1377 5 of of IN cord-010092-uftc8inx 1377 6 haemolysis haemolysis NNP cord-010092-uftc8inx 1377 7 in in IN cord-010092-uftc8inx 1377 8 concert concert NN cord-010092-uftc8inx 1377 9 with with IN cord-010092-uftc8inx 1377 10 the the DT cord-010092-uftc8inx 1377 11 presence presence NN cord-010092-uftc8inx 1377 12 of of IN cord-010092-uftc8inx 1377 13 a a DT cord-010092-uftc8inx 1377 14 positive positive JJ cord-010092-uftc8inx 1377 15 direct direct JJ cord-010092-uftc8inx 1377 16 antiglobulin antiglobulin NN cord-010092-uftc8inx 1377 17 test test NN cord-010092-uftc8inx 1377 18 characterize characterize VB cord-010092-uftc8inx 1377 19 IHA IHA NNP cord-010092-uftc8inx 1377 20 . . . cord-010092-uftc8inx 1378 1 Alloantibodies alloantibody NNS cord-010092-uftc8inx 1378 2 formed form VBD cord-010092-uftc8inx 1378 3 during during IN cord-010092-uftc8inx 1378 4 pregnancy pregnancy NN cord-010092-uftc8inx 1378 5 and/or and/or CC cord-010092-uftc8inx 1379 1 after after IN cord-010092-uftc8inx 1379 2 prior prior JJ cord-010092-uftc8inx 1379 3 transfusions transfusion NNS cord-010092-uftc8inx 1379 4 may may MD cord-010092-uftc8inx 1379 5 cause cause VB cord-010092-uftc8inx 1379 6 acute acute JJ cord-010092-uftc8inx 1379 7 or or CC cord-010092-uftc8inx 1379 8 delayed delay VBN cord-010092-uftc8inx 1379 9 haemolytic haemolytic JJ cord-010092-uftc8inx 1379 10 transfusion transfusion NN cord-010092-uftc8inx 1379 11 reaction reaction NN cord-010092-uftc8inx 1379 12 after after IN cord-010092-uftc8inx 1379 13 transfusion transfusion NN cord-010092-uftc8inx 1379 14 of of IN cord-010092-uftc8inx 1379 15 a a DT cord-010092-uftc8inx 1379 16 RBC RBC NNP cord-010092-uftc8inx 1379 17 product product NN cord-010092-uftc8inx 1379 18 incompatible incompatible JJ cord-010092-uftc8inx 1379 19 with with IN cord-010092-uftc8inx 1379 20 the the DT cord-010092-uftc8inx 1379 21 specificity specificity NN cord-010092-uftc8inx 1379 22 of of IN cord-010092-uftc8inx 1379 23 the the DT cord-010092-uftc8inx 1379 24 alloantibody alloantibody NN cord-010092-uftc8inx 1379 25 . . . cord-010092-uftc8inx 1380 1 Autoantibodies autoantibody NNS cord-010092-uftc8inx 1380 2 to to IN cord-010092-uftc8inx 1380 3 RBCs rbc NNS cord-010092-uftc8inx 1380 4 reduce reduce VB cord-010092-uftc8inx 1380 5 the the DT cord-010092-uftc8inx 1380 6 survival survival NN cord-010092-uftc8inx 1380 7 of of IN cord-010092-uftc8inx 1380 8 endogenous endogenous JJ cord-010092-uftc8inx 1380 9 and and CC cord-010092-uftc8inx 1380 10 hamper hamper VB cord-010092-uftc8inx 1380 11 the the DT cord-010092-uftc8inx 1380 12 recovery recovery NN cord-010092-uftc8inx 1380 13 of of IN cord-010092-uftc8inx 1380 14 donor donor NN cord-010092-uftc8inx 1380 15 RBCs rbc NNS cord-010092-uftc8inx 1380 16 after after IN cord-010092-uftc8inx 1380 17 transfusion transfusion NN cord-010092-uftc8inx 1380 18 . . . cord-010092-uftc8inx 1381 1 Lymphoproliferative lymphoproliferative JJ cord-010092-uftc8inx 1381 2 disease disease NN cord-010092-uftc8inx 1381 3 , , , cord-010092-uftc8inx 1381 4 autoimmune autoimmune JJ cord-010092-uftc8inx 1381 5 disease disease NN cord-010092-uftc8inx 1381 6 , , , cord-010092-uftc8inx 1381 7 infection infection NN cord-010092-uftc8inx 1381 8 or or CC cord-010092-uftc8inx 1381 9 drugs drug NNS cord-010092-uftc8inx 1381 10 often often RB cord-010092-uftc8inx 1381 11 cause cause VBP cord-010092-uftc8inx 1381 12 autoantibodies autoantibody NNS cord-010092-uftc8inx 1381 13 to to IN cord-010092-uftc8inx 1381 14 RBC RBC NNP cord-010092-uftc8inx 1381 15 , , , cord-010092-uftc8inx 1381 16 but but CC cord-010092-uftc8inx 1381 17 frequently frequently RB cord-010092-uftc8inx 1381 18 no no DT cord-010092-uftc8inx 1381 19 obvious obvious JJ cord-010092-uftc8inx 1381 20 cause cause NN cord-010092-uftc8inx 1381 21 can can MD cord-010092-uftc8inx 1381 22 be be VB cord-010092-uftc8inx 1381 23 identified identify VBN cord-010092-uftc8inx 1381 24 . . . cord-010092-uftc8inx 1382 1 Besides besides IN cord-010092-uftc8inx 1382 2 the the DT cord-010092-uftc8inx 1382 3 antigen antigen NN cord-010092-uftc8inx 1382 4 specificity specificity NN cord-010092-uftc8inx 1382 5 , , , cord-010092-uftc8inx 1382 6 the the DT cord-010092-uftc8inx 1382 7 isotype isotype NN cord-010092-uftc8inx 1382 8 critically critically RB cord-010092-uftc8inx 1382 9 determines determine VBZ cord-010092-uftc8inx 1382 10 the the DT cord-010092-uftc8inx 1382 11 biological biological JJ cord-010092-uftc8inx 1382 12 activity activity NN cord-010092-uftc8inx 1382 13 of of IN cord-010092-uftc8inx 1382 14 RBC RBC NNP cord-010092-uftc8inx 1382 15 antibodies antibody NNS cord-010092-uftc8inx 1382 16 in in IN cord-010092-uftc8inx 1382 17 vivo vivo NN cord-010092-uftc8inx 1382 18 . . . cord-010092-uftc8inx 1383 1 The the DT cord-010092-uftc8inx 1383 2 isotype isotype NN cord-010092-uftc8inx 1383 3 defines define VBZ cord-010092-uftc8inx 1383 4 the the DT cord-010092-uftc8inx 1383 5 affinity affinity NN cord-010092-uftc8inx 1383 6 to to IN cord-010092-uftc8inx 1383 7 Fc Fc NNP cord-010092-uftc8inx 1383 8 - - HYPH cord-010092-uftc8inx 1383 9 gamma gamma NN cord-010092-uftc8inx 1383 10 receptors receptor NNS cord-010092-uftc8inx 1383 11 on on IN cord-010092-uftc8inx 1383 12 cells cell NNS cord-010092-uftc8inx 1383 13 of of IN cord-010092-uftc8inx 1383 14 the the DT cord-010092-uftc8inx 1383 15 reticuloendothelial reticuloendothelial JJ cord-010092-uftc8inx 1383 16 system system NN cord-010092-uftc8inx 1383 17 as as RB cord-010092-uftc8inx 1383 18 well well RB cord-010092-uftc8inx 1383 19 as as IN cord-010092-uftc8inx 1383 20 the the DT cord-010092-uftc8inx 1383 21 capacity capacity NN cord-010092-uftc8inx 1383 22 to to TO cord-010092-uftc8inx 1383 23 activate activate VB cord-010092-uftc8inx 1383 24 the the DT cord-010092-uftc8inx 1383 25 classical classical JJ cord-010092-uftc8inx 1383 26 pathway pathway NN cord-010092-uftc8inx 1383 27 of of IN cord-010092-uftc8inx 1383 28 complement complement NN cord-010092-uftc8inx 1383 29 , , , cord-010092-uftc8inx 1383 30 IgM IgM NNP cord-010092-uftc8inx 1383 31 being be VBG cord-010092-uftc8inx 1383 32 the the DT cord-010092-uftc8inx 1383 33 most most RBS cord-010092-uftc8inx 1383 34 effective effective JJ cord-010092-uftc8inx 1383 35 . . . cord-010092-uftc8inx 1384 1 Antibody antibody NN cord-010092-uftc8inx 1384 2 - - HYPH cord-010092-uftc8inx 1384 3 mediated mediate VBN cord-010092-uftc8inx 1384 4 complement complement NN cord-010092-uftc8inx 1384 5 activation activation NN cord-010092-uftc8inx 1384 6 results result NNS cord-010092-uftc8inx 1384 7 in in IN cord-010092-uftc8inx 1384 8 the the DT cord-010092-uftc8inx 1384 9 opsonisation opsonisation NN cord-010092-uftc8inx 1384 10 of of IN cord-010092-uftc8inx 1384 11 RBC RBC NNP cord-010092-uftc8inx 1384 12 with with IN cord-010092-uftc8inx 1384 13 C3bc C3bc NNP cord-010092-uftc8inx 1384 14 / / SYM cord-010092-uftc8inx 1384 15 C3d C3d NNP cord-010092-uftc8inx 1384 16 with with IN cord-010092-uftc8inx 1384 17 subsequent subsequent JJ cord-010092-uftc8inx 1384 18 complement complement NN cord-010092-uftc8inx 1384 19 receptor receptor NN cord-010092-uftc8inx 1384 20 - - HYPH cord-010092-uftc8inx 1384 21 mediated mediate VBN cord-010092-uftc8inx 1384 22 removal removal NN cord-010092-uftc8inx 1384 23 by by IN cord-010092-uftc8inx 1384 24 phagocytes phagocyte NNS cord-010092-uftc8inx 1384 25 ( ( -LRB- cord-010092-uftc8inx 1384 26 extravascular extravascular NNP cord-010092-uftc8inx 1384 27 haemolysis haemolysis NNP cord-010092-uftc8inx 1384 28 ) ) -RRB- cord-010092-uftc8inx 1384 29 . . . cord-010092-uftc8inx 1385 1 Occasionally occasionally RB cord-010092-uftc8inx 1385 2 , , , cord-010092-uftc8inx 1385 3 complement complement JJ cord-010092-uftc8inx 1385 4 activation activation NN cord-010092-uftc8inx 1385 5 proceeds proceed NNS cord-010092-uftc8inx 1385 6 via via IN cord-010092-uftc8inx 1385 7 the the DT cord-010092-uftc8inx 1385 8 activation activation NN cord-010092-uftc8inx 1385 9 of of IN cord-010092-uftc8inx 1385 10 C5 C5 NNP cord-010092-uftc8inx 1385 11 to to IN cord-010092-uftc8inx 1385 12 the the DT cord-010092-uftc8inx 1385 13 formation formation NN cord-010092-uftc8inx 1385 14 and and CC cord-010092-uftc8inx 1385 15 insertion insertion NN cord-010092-uftc8inx 1385 16 of of IN cord-010092-uftc8inx 1385 17 the the DT cord-010092-uftc8inx 1385 18 membrane membrane NN cord-010092-uftc8inx 1385 19 attack attack NN cord-010092-uftc8inx 1385 20 complex complex NN cord-010092-uftc8inx 1385 21 resulting result VBG cord-010092-uftc8inx 1385 22 in in IN cord-010092-uftc8inx 1385 23 intravascular intravascular JJ cord-010092-uftc8inx 1385 24 haemolysis haemolysis NN cord-010092-uftc8inx 1385 25 . . . cord-010092-uftc8inx 1386 1 There there EX cord-010092-uftc8inx 1386 2 is be VBZ cord-010092-uftc8inx 1386 3 growing grow VBG cord-010092-uftc8inx 1386 4 evidence evidence NN cord-010092-uftc8inx 1386 5 that that IN cord-010092-uftc8inx 1386 6 the the DT cord-010092-uftc8inx 1386 7 innate innate JJ cord-010092-uftc8inx 1386 8 immune immune JJ cord-010092-uftc8inx 1386 9 system system NN cord-010092-uftc8inx 1386 10 plays play VBZ cord-010092-uftc8inx 1386 11 an an DT cord-010092-uftc8inx 1386 12 important important JJ cord-010092-uftc8inx 1386 13 role role NN cord-010092-uftc8inx 1386 14 in in IN cord-010092-uftc8inx 1386 15 the the DT cord-010092-uftc8inx 1386 16 pathogenesis pathogenesis NN cord-010092-uftc8inx 1386 17 of of IN cord-010092-uftc8inx 1386 18 IHA IHA NNP cord-010092-uftc8inx 1386 19 . . . cord-010092-uftc8inx 1387 1 The the DT cord-010092-uftc8inx 1387 2 process process NN cord-010092-uftc8inx 1387 3 of of IN cord-010092-uftc8inx 1387 4 complement complement NN cord-010092-uftc8inx 1387 5 - - HYPH cord-010092-uftc8inx 1387 6 mediated mediate VBN cord-010092-uftc8inx 1387 7 haemolysis haemolysis NN cord-010092-uftc8inx 1387 8 results result NNS cord-010092-uftc8inx 1387 9 in in IN cord-010092-uftc8inx 1387 10 systemic systemic JJ cord-010092-uftc8inx 1387 11 inflammation inflammation NN cord-010092-uftc8inx 1387 12 , , , cord-010092-uftc8inx 1387 13 which which WDT cord-010092-uftc8inx 1387 14 contributes contribute VBZ cord-010092-uftc8inx 1387 15 to to IN cord-010092-uftc8inx 1387 16 morbidity morbidity NN cord-010092-uftc8inx 1387 17 and and CC cord-010092-uftc8inx 1387 18 mortality mortality NN cord-010092-uftc8inx 1387 19 of of IN cord-010092-uftc8inx 1387 20 patients patient NNS cord-010092-uftc8inx 1387 21 suffering suffer VBG cord-010092-uftc8inx 1387 22 from from IN cord-010092-uftc8inx 1387 23 IHA IHA NNP cord-010092-uftc8inx 1387 24 . . . cord-010092-uftc8inx 1388 1 Complement complement JJ cord-010092-uftc8inx 1388 2 activation activation NN cord-010092-uftc8inx 1388 3 results result NNS cord-010092-uftc8inx 1388 4 in in IN cord-010092-uftc8inx 1388 5 the the DT cord-010092-uftc8inx 1388 6 release release NN cord-010092-uftc8inx 1388 7 of of IN cord-010092-uftc8inx 1388 8 anaphylatoxins anaphylatoxins NNP cord-010092-uftc8inx 1388 9 , , , cord-010092-uftc8inx 1388 10 which which WDT cord-010092-uftc8inx 1388 11 are be VBP cord-010092-uftc8inx 1388 12 strongly strongly RB cord-010092-uftc8inx 1388 13 vasoactive vasoactive JJ cord-010092-uftc8inx 1388 14 and and CC cord-010092-uftc8inx 1388 15 mediate mediate VB cord-010092-uftc8inx 1388 16 chemotaxis chemotaxis NN cord-010092-uftc8inx 1388 17 , , , cord-010092-uftc8inx 1388 18 inflammation inflammation NN cord-010092-uftc8inx 1388 19 and and CC cord-010092-uftc8inx 1388 20 formation formation NN cord-010092-uftc8inx 1388 21 of of IN cord-010092-uftc8inx 1388 22 radical radical JJ cord-010092-uftc8inx 1388 23 oxygen oxygen NN cord-010092-uftc8inx 1388 24 species specie NNS cord-010092-uftc8inx 1388 25 . . . cord-010092-uftc8inx 1389 1 Release release NN cord-010092-uftc8inx 1389 2 of of IN cord-010092-uftc8inx 1389 3 cell cell NN cord-010092-uftc8inx 1389 4 - - HYPH cord-010092-uftc8inx 1389 5 free free JJ cord-010092-uftc8inx 1389 6 haemoglobin haemoglobin NN cord-010092-uftc8inx 1389 7 and and CC cord-010092-uftc8inx 1389 8 cell cell NN cord-010092-uftc8inx 1389 9 - - HYPH cord-010092-uftc8inx 1389 10 free free JJ cord-010092-uftc8inx 1389 11 haeme haeme NN cord-010092-uftc8inx 1389 12 upon upon IN cord-010092-uftc8inx 1389 13 haemolysis haemolysis NNP cord-010092-uftc8inx 1389 14 induces induce VBZ cord-010092-uftc8inx 1389 15 endothelial endothelial JJ cord-010092-uftc8inx 1389 16 cell cell NN cord-010092-uftc8inx 1389 17 activation activation NN cord-010092-uftc8inx 1389 18 , , , cord-010092-uftc8inx 1389 19 NO no NN cord-010092-uftc8inx 1389 20 - - HYPH cord-010092-uftc8inx 1389 21 depletion depletion NN cord-010092-uftc8inx 1389 22 , , , cord-010092-uftc8inx 1389 23 cytotoxicity cytotoxicity NN cord-010092-uftc8inx 1389 24 , , , cord-010092-uftc8inx 1389 25 ROS ROS NNP cord-010092-uftc8inx 1389 26 formation formation NN cord-010092-uftc8inx 1389 27 and and CC cord-010092-uftc8inx 1389 28 neutrophil neutrophil NN cord-010092-uftc8inx 1389 29 activation activation NN cord-010092-uftc8inx 1389 30 . . . cord-010092-uftc8inx 1390 1 Natural natural JJ cord-010092-uftc8inx 1390 2 plasma plasma NN cord-010092-uftc8inx 1390 3 scavengers scavenger NNS cord-010092-uftc8inx 1390 4 , , , cord-010092-uftc8inx 1390 5 such such JJ cord-010092-uftc8inx 1390 6 as as IN cord-010092-uftc8inx 1390 7 haptoglobin haptoglobin NN cord-010092-uftc8inx 1390 8 and and CC cord-010092-uftc8inx 1390 9 hemopexin hemopexin NN cord-010092-uftc8inx 1390 10 complex complex NN cord-010092-uftc8inx 1390 11 with with IN cord-010092-uftc8inx 1390 12 their -PRON- PRP$ cord-010092-uftc8inx 1390 13 target target NN cord-010092-uftc8inx 1390 14 molecules molecule NNS cord-010092-uftc8inx 1390 15 , , , cord-010092-uftc8inx 1390 16 cell cell NN cord-010092-uftc8inx 1390 17 - - HYPH cord-010092-uftc8inx 1390 18 free free JJ cord-010092-uftc8inx 1390 19 haemoglobin haemoglobin NN cord-010092-uftc8inx 1390 20 and and CC cord-010092-uftc8inx 1390 21 haeme haeme NNP cord-010092-uftc8inx 1390 22 , , , cord-010092-uftc8inx 1390 23 with with IN cord-010092-uftc8inx 1390 24 subsequent subsequent JJ cord-010092-uftc8inx 1390 25 removal removal NN cord-010092-uftc8inx 1390 26 of of IN cord-010092-uftc8inx 1390 27 the the DT cord-010092-uftc8inx 1390 28 complexes complex NNS cord-010092-uftc8inx 1390 29 via via IN cord-010092-uftc8inx 1390 30 CD163 CD163 NNP cord-010092-uftc8inx 1390 31 and and CC cord-010092-uftc8inx 1390 32 CD91-mediated cd91-mediated CD cord-010092-uftc8inx 1390 33 phagocytosis phagocytosis NN cord-010092-uftc8inx 1390 34 . . . cord-010092-uftc8inx 1391 1 Although although IN cord-010092-uftc8inx 1391 2 being be VBG cord-010092-uftc8inx 1391 3 positive positive JJ cord-010092-uftc8inx 1391 4 acute acute JJ cord-010092-uftc8inx 1391 5 phase phase NN cord-010092-uftc8inx 1391 6 proteins protein NNS cord-010092-uftc8inx 1391 7 due due JJ cord-010092-uftc8inx 1391 8 to to IN cord-010092-uftc8inx 1391 9 consumption consumption NN cord-010092-uftc8inx 1392 1 the the DT cord-010092-uftc8inx 1392 2 plasma plasma NN cord-010092-uftc8inx 1392 3 scavengers scavenger NNS cord-010092-uftc8inx 1392 4 become become VBP cord-010092-uftc8inx 1392 5 exhausted exhausted JJ cord-010092-uftc8inx 1392 6 during during IN cord-010092-uftc8inx 1392 7 chronic chronic JJ cord-010092-uftc8inx 1392 8 haemolysis haemolysis NNP cord-010092-uftc8inx 1392 9 thereby thereby RB cord-010092-uftc8inx 1392 10 failing fail VBG cord-010092-uftc8inx 1392 11 to to TO cord-010092-uftc8inx 1392 12 prevent prevent VB cord-010092-uftc8inx 1392 13 the the DT cord-010092-uftc8inx 1392 14 adverse adverse JJ cord-010092-uftc8inx 1392 15 biological biological JJ cord-010092-uftc8inx 1392 16 effects effect NNS cord-010092-uftc8inx 1392 17 of of IN cord-010092-uftc8inx 1392 18 cell cell NN cord-010092-uftc8inx 1392 19 - - HYPH cord-010092-uftc8inx 1392 20 free free JJ cord-010092-uftc8inx 1392 21 haemoglobin haemoglobin NN cord-010092-uftc8inx 1392 22 and and CC cord-010092-uftc8inx 1392 23 haeme haeme NN cord-010092-uftc8inx 1392 24 in in IN cord-010092-uftc8inx 1392 25 the the DT cord-010092-uftc8inx 1392 26 circulation circulation NN cord-010092-uftc8inx 1392 27 . . . cord-010092-uftc8inx 1393 1 Inducible inducible JJ cord-010092-uftc8inx 1393 2 haeme haeme NNP cord-010092-uftc8inx 1393 3 oxygenase-1 oxygenase-1 NNP cord-010092-uftc8inx 1393 4 ( ( -LRB- cord-010092-uftc8inx 1393 5 HO-1 HO-1 NNP cord-010092-uftc8inx 1393 6 ) ) -RRB- cord-010092-uftc8inx 1393 7 is be VBZ cord-010092-uftc8inx 1393 8 an an DT cord-010092-uftc8inx 1393 9 efficient efficient JJ cord-010092-uftc8inx 1393 10 cellular cellular JJ cord-010092-uftc8inx 1393 11 scavenger scavenger NN cord-010092-uftc8inx 1393 12 by by IN cord-010092-uftc8inx 1393 13 breaking break VBG cord-010092-uftc8inx 1393 14 down down RP cord-010092-uftc8inx 1393 15 haeme haeme NNP cord-010092-uftc8inx 1393 16 into into IN cord-010092-uftc8inx 1393 17 biliverdin biliverdin NNP cord-010092-uftc8inx 1393 18 with with IN cord-010092-uftc8inx 1393 19 subsequent subsequent JJ cord-010092-uftc8inx 1393 20 formation formation NN cord-010092-uftc8inx 1393 21 of of IN cord-010092-uftc8inx 1393 22 bilirubin bilirubin NN cord-010092-uftc8inx 1393 23 , , , cord-010092-uftc8inx 1393 24 CO co NN cord-010092-uftc8inx 1393 25 and and CC cord-010092-uftc8inx 1393 26 ferrous ferrous JJ cord-010092-uftc8inx 1393 27 iron iron NN cord-010092-uftc8inx 1393 28 with with IN cord-010092-uftc8inx 1393 29 subsequent subsequent JJ cord-010092-uftc8inx 1393 30 oxidation oxidation NN cord-010092-uftc8inx 1393 31 to to IN cord-010092-uftc8inx 1393 32 ferric ferric JJ cord-010092-uftc8inx 1393 33 iron iron NN cord-010092-uftc8inx 1393 34 and and CC cord-010092-uftc8inx 1393 35 storage storage NN cord-010092-uftc8inx 1393 36 by by IN cord-010092-uftc8inx 1393 37 the the DT cord-010092-uftc8inx 1393 38 ferritin ferritin NN cord-010092-uftc8inx 1393 39 H H NNP cord-010092-uftc8inx 1393 40 chain chain NN cord-010092-uftc8inx 1393 41 . . . cord-010092-uftc8inx 1394 1 HO-1 HO-1 NNP cord-010092-uftc8inx 1394 2 has have VBZ cord-010092-uftc8inx 1394 3 an an DT cord-010092-uftc8inx 1394 4 established establish VBN cord-010092-uftc8inx 1394 5 role role NN cord-010092-uftc8inx 1394 6 in in IN cord-010092-uftc8inx 1394 7 the the DT cord-010092-uftc8inx 1394 8 systemic systemic JJ cord-010092-uftc8inx 1394 9 protection protection NN cord-010092-uftc8inx 1394 10 from from IN cord-010092-uftc8inx 1394 11 systemic systemic JJ cord-010092-uftc8inx 1394 12 inflammation inflammation NN cord-010092-uftc8inx 1394 13 induced induce VBN cord-010092-uftc8inx 1394 14 by by IN cord-010092-uftc8inx 1394 15 haemolytic haemolytic JJ cord-010092-uftc8inx 1394 16 and and CC cord-010092-uftc8inx 1394 17 non non JJ cord-010092-uftc8inx 1394 18 - - JJ cord-010092-uftc8inx 1394 19 haemolytic haemolytic JJ cord-010092-uftc8inx 1394 20 diseases disease NNS cord-010092-uftc8inx 1394 21 . . . cord-010092-uftc8inx 1395 1 The the DT cord-010092-uftc8inx 1395 2 lecture lecture NN cord-010092-uftc8inx 1395 3 will will MD cord-010092-uftc8inx 1395 4 emphasise emphasise VB cord-010092-uftc8inx 1395 5 the the DT cord-010092-uftc8inx 1395 6 role role NN cord-010092-uftc8inx 1395 7 of of IN cord-010092-uftc8inx 1395 8 innate innate JJ cord-010092-uftc8inx 1395 9 immunity immunity NN cord-010092-uftc8inx 1395 10 with with IN cord-010092-uftc8inx 1395 11 a a DT cord-010092-uftc8inx 1395 12 special special JJ cord-010092-uftc8inx 1395 13 focus focus NN cord-010092-uftc8inx 1395 14 on on IN cord-010092-uftc8inx 1395 15 different different JJ cord-010092-uftc8inx 1395 16 plasma plasma NN cord-010092-uftc8inx 1395 17 - - HYPH cord-010092-uftc8inx 1395 18 and and CC cord-010092-uftc8inx 1395 19 cellular cellular JJ cord-010092-uftc8inx 1395 20 systems system NNS cord-010092-uftc8inx 1395 21 involved involve VBN cord-010092-uftc8inx 1395 22 in in IN cord-010092-uftc8inx 1395 23 the the DT cord-010092-uftc8inx 1395 24 pathogenesis pathogenesis NN cord-010092-uftc8inx 1395 25 of of IN cord-010092-uftc8inx 1395 26 systemic systemic JJ cord-010092-uftc8inx 1395 27 inflammation inflammation NN cord-010092-uftc8inx 1395 28 in in IN cord-010092-uftc8inx 1395 29 patients patient NNS cord-010092-uftc8inx 1395 30 suffering suffer VBG cord-010092-uftc8inx 1395 31 from from IN cord-010092-uftc8inx 1395 32 IHA IHA NNP cord-010092-uftc8inx 1395 33 . . . cord-010092-uftc8inx 1396 1 3D 3D NNP cord-010092-uftc8inx 1396 2 - - HYPH cord-010092-uftc8inx 1396 3 S11 S11 NNP cord-010092-uftc8inx 1396 4 - - HYPH cord-010092-uftc8inx 1396 5 02 02 CD cord-010092-uftc8inx 1396 6 UNDERSTANDING understanding NN cord-010092-uftc8inx 1397 1 ERYTHROCYTE ERYTHROCYTE NNP cord-010092-uftc8inx 1397 2 CLEARANCE clearance NN cord-010092-uftc8inx 1397 3 C C NNP cord-010092-uftc8inx 1397 4 Roussel Roussel NNP cord-010092-uftc8inx 1397 5 , , , cord-010092-uftc8inx 1397 6 P p NN cord-010092-uftc8inx 1397 7 Amireault Amireault NNP cord-010092-uftc8inx 1397 8 , , , cord-010092-uftc8inx 1397 9 P P NNP cord-010092-uftc8inx 1397 10 Ndour Ndour NNP cord-010092-uftc8inx 1397 11 and and CC cord-010092-uftc8inx 1397 12 P P NNP cord-010092-uftc8inx 1397 13 Buffet Buffet NNP cord-010092-uftc8inx 1397 14 Research Research NNP cord-010092-uftc8inx 1397 15 and and CC cord-010092-uftc8inx 1397 16 teaching teaching NN cord-010092-uftc8inx 1397 17 , , , cord-010092-uftc8inx 1397 18 Institut Institut NNP cord-010092-uftc8inx 1397 19 National National NNP cord-010092-uftc8inx 1397 20 de de NNP cord-010092-uftc8inx 1397 21 la la NNP cord-010092-uftc8inx 1397 22 Transfusion Transfusion NNP cord-010092-uftc8inx 1397 23 Sanguine Sanguine NNP cord-010092-uftc8inx 1397 24 , , , cord-010092-uftc8inx 1397 25 Paris Paris NNP cord-010092-uftc8inx 1397 26 , , , cord-010092-uftc8inx 1397 27 France France NNP cord-010092-uftc8inx 1398 1 The the DT cord-010092-uftc8inx 1398 2 clearance clearance NN cord-010092-uftc8inx 1398 3 of of IN cord-010092-uftc8inx 1398 4 erythrocytes erythrocyte NNS cord-010092-uftc8inx 1398 5 is be VBZ cord-010092-uftc8inx 1398 6 essential essential JJ cord-010092-uftc8inx 1398 7 in in IN cord-010092-uftc8inx 1398 8 physiology physiology NN cord-010092-uftc8inx 1398 9 , , , cord-010092-uftc8inx 1398 10 disease disease NN cord-010092-uftc8inx 1398 11 and and CC cord-010092-uftc8inx 1398 12 transfusion transfusion NN cord-010092-uftc8inx 1398 13 . . . cord-010092-uftc8inx 1399 1 Elimination elimination NN cord-010092-uftc8inx 1399 2 of of IN cord-010092-uftc8inx 1399 3 erythrocytes erythrocyte NNS cord-010092-uftc8inx 1399 4 altered alter VBN cord-010092-uftc8inx 1399 5 because because RB cord-010092-uftc8inx 1399 6 of of IN cord-010092-uftc8inx 1399 7 senescence senescence NN cord-010092-uftc8inx 1399 8 or or CC cord-010092-uftc8inx 1399 9 pathological pathological JJ cord-010092-uftc8inx 1399 10 processes process NNS cord-010092-uftc8inx 1399 11 is be VBZ cord-010092-uftc8inx 1399 12 expected expect VBN cord-010092-uftc8inx 1399 13 to to TO cord-010092-uftc8inx 1399 14 protect protect VB cord-010092-uftc8inx 1399 15 the the DT cord-010092-uftc8inx 1399 16 microcirculation microcirculation NN cord-010092-uftc8inx 1399 17 from from IN cord-010092-uftc8inx 1399 18 obstruction obstruction NN cord-010092-uftc8inx 1399 19 by by IN cord-010092-uftc8inx 1399 20 adhesive adhesive JJ cord-010092-uftc8inx 1399 21 or or CC cord-010092-uftc8inx 1399 22 rigid rigid JJ cord-010092-uftc8inx 1399 23 erythrocytes erythrocyte NNS cord-010092-uftc8inx 1399 24 . . . cord-010092-uftc8inx 1400 1 It -PRON- PRP cord-010092-uftc8inx 1400 2 also also RB cord-010092-uftc8inx 1400 3 contributes contribute VBZ cord-010092-uftc8inx 1400 4 to to IN cord-010092-uftc8inx 1400 5 the the DT cord-010092-uftc8inx 1400 6 harmful harmful JJ cord-010092-uftc8inx 1400 7 consequences consequence NNS cord-010092-uftc8inx 1400 8 of of IN cord-010092-uftc8inx 1400 9 anemia anemia NN cord-010092-uftc8inx 1400 10 and and CC cord-010092-uftc8inx 1400 11 hemolysis hemolysis NN cord-010092-uftc8inx 1400 12 in in IN cord-010092-uftc8inx 1400 13 hereditary hereditary JJ cord-010092-uftc8inx 1400 14 and and CC cord-010092-uftc8inx 1400 15 acquired acquire VBD cord-010092-uftc8inx 1400 16 red red JJ cord-010092-uftc8inx 1400 17 blood blood NN cord-010092-uftc8inx 1400 18 cells cell NNS cord-010092-uftc8inx 1400 19 diseases disease NNS cord-010092-uftc8inx 1400 20 as as RB cord-010092-uftc8inx 1400 21 well well RB cord-010092-uftc8inx 1400 22 as as IN cord-010092-uftc8inx 1400 23 in in IN cord-010092-uftc8inx 1400 24 conditions condition NNS cord-010092-uftc8inx 1400 25 associated associate VBN cord-010092-uftc8inx 1400 26 with with IN cord-010092-uftc8inx 1400 27 auto auto NN cord-010092-uftc8inx 1400 28 - - : cord-010092-uftc8inx 1400 29 or or CC cord-010092-uftc8inx 1400 30 allo allo NN cord-010092-uftc8inx 1400 31 - - HYPH cord-010092-uftc8inx 1400 32 immunization immunization NN cord-010092-uftc8inx 1400 33 . . . cord-010092-uftc8inx 1401 1 Immunobiology Immunobiology NNP cord-010092-uftc8inx 1401 2 has have VBZ cord-010092-uftc8inx 1401 3 explored explore VBN cord-010092-uftc8inx 1401 4 in in IN cord-010092-uftc8inx 1401 5 great great JJ cord-010092-uftc8inx 1401 6 details detail NNS cord-010092-uftc8inx 1401 7 antibody antibody NN cord-010092-uftc8inx 1401 8 - - HYPH cord-010092-uftc8inx 1401 9 mediated mediate VBN cord-010092-uftc8inx 1401 10 clearance clearance NN cord-010092-uftc8inx 1401 11 of of IN cord-010092-uftc8inx 1401 12 erythrocytes erythrocyte NNS cord-010092-uftc8inx 1401 13 but but CC cord-010092-uftc8inx 1401 14 conventional conventional JJ cord-010092-uftc8inx 1401 15 approaches approach NNS cord-010092-uftc8inx 1401 16 may may MD cord-010092-uftc8inx 1401 17 not not RB cord-010092-uftc8inx 1401 18 be be VB cord-010092-uftc8inx 1401 19 fully fully RB cord-010092-uftc8inx 1401 20 operational operational JJ cord-010092-uftc8inx 1401 21 to to TO cord-010092-uftc8inx 1401 22 explain explain VB cord-010092-uftc8inx 1401 23 Delayed Delayed NNP cord-010092-uftc8inx 1401 24 Hemolytic Hemolytic NNP cord-010092-uftc8inx 1401 25 Transfusion Transfusion NNP cord-010092-uftc8inx 1401 26 Reactions reaction NNS cord-010092-uftc8inx 1401 27 . . . cord-010092-uftc8inx 1402 1 Some some DT cord-010092-uftc8inx 1402 2 important important JJ cord-010092-uftc8inx 1402 3 clearance clearance NN cord-010092-uftc8inx 1402 4 processes process NNS cord-010092-uftc8inx 1402 5 are be VBP cord-010092-uftc8inx 1402 6 independent independent JJ cord-010092-uftc8inx 1402 7 from from IN cord-010092-uftc8inx 1402 8 the the DT cord-010092-uftc8inx 1402 9 recognition recognition NN cord-010092-uftc8inx 1402 10 of of IN cord-010092-uftc8inx 1402 11 molecules molecule NNS cord-010092-uftc8inx 1402 12 or or CC cord-010092-uftc8inx 1402 13 antigens antigen NNS cord-010092-uftc8inx 1402 14 on on IN cord-010092-uftc8inx 1402 15 the the DT cord-010092-uftc8inx 1402 16 erythrocyte erythrocyte NN cord-010092-uftc8inx 1402 17 surface surface NN cord-010092-uftc8inx 1402 18 . . . cord-010092-uftc8inx 1403 1 Increased increase VBN cord-010092-uftc8inx 1403 2 erythrocyte erythrocyte NN cord-010092-uftc8inx 1403 3 stiffness stiffness NN cord-010092-uftc8inx 1403 4 triggers trigger VBZ cord-010092-uftc8inx 1403 5 their -PRON- PRP$ cord-010092-uftc8inx 1403 6 clearance clearance NN cord-010092-uftc8inx 1403 7 in in IN cord-010092-uftc8inx 1403 8 hereditary hereditary JJ cord-010092-uftc8inx 1403 9 spherocytosis spherocytosis NN cord-010092-uftc8inx 1403 10 , , , cord-010092-uftc8inx 1403 11 malaria malaria NN cord-010092-uftc8inx 1403 12 and and CC cord-010092-uftc8inx 1403 13 possibly possibly RB cord-010092-uftc8inx 1403 14 also also RB cord-010092-uftc8inx 1403 15 in in IN cord-010092-uftc8inx 1403 16 the the DT cord-010092-uftc8inx 1403 17 context context NN cord-010092-uftc8inx 1403 18 of of IN cord-010092-uftc8inx 1403 19 autoimmune autoimmune JJ cord-010092-uftc8inx 1403 20 anemia anemia NN cord-010092-uftc8inx 1403 21 . . . cord-010092-uftc8inx 1404 1 Knowns known NNS cord-010092-uftc8inx 1404 2 and and CC cord-010092-uftc8inx 1404 3 unknowns unknown NNS cord-010092-uftc8inx 1404 4 on on IN cord-010092-uftc8inx 1404 5 the the DT cord-010092-uftc8inx 1404 6 mechanisms mechanism NNS cord-010092-uftc8inx 1404 7 and and CC cord-010092-uftc8inx 1404 8 sites site NNS cord-010092-uftc8inx 1404 9 of of IN cord-010092-uftc8inx 1404 10 erythrocyte erythrocyte NN cord-010092-uftc8inx 1404 11 clearance clearance NN cord-010092-uftc8inx 1404 12 will will MD cord-010092-uftc8inx 1404 13 be be VB cord-010092-uftc8inx 1404 14 presented present VBN cord-010092-uftc8inx 1404 15 based base VBN cord-010092-uftc8inx 1404 16 on on IN cord-010092-uftc8inx 1404 17 a a DT cord-010092-uftc8inx 1404 18 critical critical JJ cord-010092-uftc8inx 1404 19 review review NN cord-010092-uftc8inx 1404 20 of of IN cord-010092-uftc8inx 1404 21 old old JJ cord-010092-uftc8inx 1404 22 and and CC cord-010092-uftc8inx 1404 23 recent recent JJ cord-010092-uftc8inx 1404 24 contributions contribution NNS cord-010092-uftc8inx 1404 25 . . . cord-010092-uftc8inx 1405 1 3D 3D NNP cord-010092-uftc8inx 1405 2 - - HYPH cord-010092-uftc8inx 1405 3 S11 S11 NNP cord-010092-uftc8inx 1405 4 - - HYPH cord-010092-uftc8inx 1405 5 03 03 CD cord-010092-uftc8inx 1405 6 Cardiovascular Cardiovascular NNP cord-010092-uftc8inx 1405 7 and and CC cord-010092-uftc8inx 1405 8 Endocrine endocrine JJ cord-010092-uftc8inx 1405 9 - - HYPH cord-010092-uftc8inx 1405 10 metabolic metabolic JJ cord-010092-uftc8inx 1405 11 Diseases disease NNS cord-010092-uftc8inx 1405 12 and and CC cord-010092-uftc8inx 1405 13 Aging age VBG cord-010092-uftc8inx 1405 14 , , , cord-010092-uftc8inx 1405 15 Istituto Istituto NNP cord-010092-uftc8inx 1405 16 Superiore Superiore NNP cord-010092-uftc8inx 1405 17 di di NN cord-010092-uftc8inx 1405 18 Sanit sanit NN cord-010092-uftc8inx 1406 1 a a LS cord-010092-uftc8inx 1406 2 , , , cord-010092-uftc8inx 1406 3 Rome Rome NNP cord-010092-uftc8inx 1406 4 , , , cord-010092-uftc8inx 1406 5 Italy Italy NNP cord-010092-uftc8inx 1406 6 Existing exist VBG cord-010092-uftc8inx 1406 7 literature literature NN cord-010092-uftc8inx 1406 8 indicates indicate VBZ cord-010092-uftc8inx 1406 9 that that IN cord-010092-uftc8inx 1406 10 red red JJ cord-010092-uftc8inx 1406 11 blood blood NN cord-010092-uftc8inx 1406 12 cells cell NNS cord-010092-uftc8inx 1406 13 ( ( -LRB- cord-010092-uftc8inx 1406 14 RBCs rbc NNS cord-010092-uftc8inx 1406 15 ) ) -RRB- cord-010092-uftc8inx 1406 16 , , , cord-010092-uftc8inx 1406 17 beyond beyond IN cord-010092-uftc8inx 1406 18 gas gas NN cord-010092-uftc8inx 1406 19 transport transport NN cord-010092-uftc8inx 1406 20 , , , cord-010092-uftc8inx 1406 21 exert exert VB cord-010092-uftc8inx 1406 22 a a DT cord-010092-uftc8inx 1406 23 complex complex JJ cord-010092-uftc8inx 1406 24 role role NN cord-010092-uftc8inx 1406 25 in in IN cord-010092-uftc8inx 1406 26 human human JJ cord-010092-uftc8inx 1406 27 physiology physiology NN cord-010092-uftc8inx 1406 28 , , , cord-010092-uftc8inx 1406 29 being be VBG cord-010092-uftc8inx 1406 30 involved involve VBN cord-010092-uftc8inx 1406 31 in in IN cord-010092-uftc8inx 1406 32 many many JJ cord-010092-uftc8inx 1406 33 functions function NNS cord-010092-uftc8inx 1406 34 essential essential JJ cord-010092-uftc8inx 1406 35 to to TO cord-010092-uftc8inx 1406 36 maintain maintain VB cord-010092-uftc8inx 1406 37 ion ion NN cord-010092-uftc8inx 1406 38 , , , cord-010092-uftc8inx 1406 39 metabolic metabolic JJ cord-010092-uftc8inx 1406 40 and and CC cord-010092-uftc8inx 1406 41 immunological immunological JJ cord-010092-uftc8inx 1406 42 homeostasis homeostasis NN cord-010092-uftc8inx 1406 43 . . . cord-010092-uftc8inx 1407 1 RBCs rbc NNS cord-010092-uftc8inx 1407 2 display display VBP cord-010092-uftc8inx 1407 3 an an DT cord-010092-uftc8inx 1407 4 immunomodulatory immunomodulatory JJ cord-010092-uftc8inx 1407 5 activity activity NN cord-010092-uftc8inx 1407 6 on on IN cord-010092-uftc8inx 1407 7 adaptive adaptive JJ cord-010092-uftc8inx 1407 8 immune immune JJ cord-010092-uftc8inx 1407 9 cells cell NNS cord-010092-uftc8inx 1407 10 by by IN cord-010092-uftc8inx 1407 11 promoting promote VBG cord-010092-uftc8inx 1407 12 T T NNP cord-010092-uftc8inx 1407 13 cell cell NN cord-010092-uftc8inx 1407 14 growth growth NN cord-010092-uftc8inx 1407 15 and and CC cord-010092-uftc8inx 1407 16 survival survival NN cord-010092-uftc8inx 1407 17 and and CC cord-010092-uftc8inx 1407 18 inhibiting inhibit VBG cord-010092-uftc8inx 1407 19 activation activation NN cord-010092-uftc8inx 1407 20 - - HYPH cord-010092-uftc8inx 1407 21 induced induce VBN cord-010092-uftc8inx 1407 22 cell cell NN cord-010092-uftc8inx 1407 23 death death NN cord-010092-uftc8inx 1407 24 . . . cord-010092-uftc8inx 1408 1 The the DT cord-010092-uftc8inx 1408 2 balance balance NN cord-010092-uftc8inx 1408 3 between between IN cord-010092-uftc8inx 1408 4 cell cell NN cord-010092-uftc8inx 1408 5 death death NN cord-010092-uftc8inx 1408 6 and and CC cord-010092-uftc8inx 1408 7 survival survival NN cord-010092-uftc8inx 1408 8 controls control VBZ cord-010092-uftc8inx 1408 9 T T NNP cord-010092-uftc8inx 1408 10 cell cell NN cord-010092-uftc8inx 1408 11 homeostasis homeostasis NN cord-010092-uftc8inx 1408 12 and and CC cord-010092-uftc8inx 1408 13 anomalies anomaly NNS cord-010092-uftc8inx 1408 14 in in IN cord-010092-uftc8inx 1408 15 this this DT cord-010092-uftc8inx 1408 16 balance balance NN cord-010092-uftc8inx 1408 17 account account NN cord-010092-uftc8inx 1408 18 for for IN cord-010092-uftc8inx 1408 19 diseases disease NNS cord-010092-uftc8inx 1408 20 linked link VBN cord-010092-uftc8inx 1408 21 to to IN cord-010092-uftc8inx 1408 22 excessive excessive JJ cord-010092-uftc8inx 1408 23 or or CC cord-010092-uftc8inx 1408 24 faulty faulty JJ cord-010092-uftc8inx 1408 25 T t NN cord-010092-uftc8inx 1408 26 cell cell NN cord-010092-uftc8inx 1408 27 growth growth NN cord-010092-uftc8inx 1408 28 . . . cord-010092-uftc8inx 1409 1 RBCs rbc NNS cord-010092-uftc8inx 1409 2 are be VBP cord-010092-uftc8inx 1409 3 able able JJ cord-010092-uftc8inx 1409 4 to to TO cord-010092-uftc8inx 1409 5 modulate modulate VB cord-010092-uftc8inx 1409 6 innate innate JJ cord-010092-uftc8inx 1409 7 immunity immunity NN cord-010092-uftc8inx 1409 8 by by IN cord-010092-uftc8inx 1409 9 binding bind VBG cord-010092-uftc8inx 1409 10 endogenous endogenous JJ cord-010092-uftc8inx 1409 11 molecules molecule NNS cord-010092-uftc8inx 1409 12 such such JJ cord-010092-uftc8inx 1409 13 as as IN cord-010092-uftc8inx 1409 14 chemokines chemokine NNS cord-010092-uftc8inx 1409 15 and and CC cord-010092-uftc8inx 1409 16 mitochondria mitochondrion NNS cord-010092-uftc8inx 1409 17 - - HYPH cord-010092-uftc8inx 1409 18 derived derive VBN cord-010092-uftc8inx 1409 19 DNA dna NN cord-010092-uftc8inx 1409 20 , , , cord-010092-uftc8inx 1409 21 as as RB cord-010092-uftc8inx 1409 22 well well RB cord-010092-uftc8inx 1409 23 as as IN cord-010092-uftc8inx 1409 24 external external JJ cord-010092-uftc8inx 1409 25 agents agent NNS cord-010092-uftc8inx 1409 26 such such JJ cord-010092-uftc8inx 1409 27 as as IN cord-010092-uftc8inx 1409 28 pathogens pathogen NNS cord-010092-uftc8inx 1409 29 . . . cord-010092-uftc8inx 1410 1 RBCs rbc NNS cord-010092-uftc8inx 1410 2 can can MD cord-010092-uftc8inx 1410 3 also also RB cord-010092-uftc8inx 1410 4 directly directly RB cord-010092-uftc8inx 1410 5 modulate modulate VB cord-010092-uftc8inx 1410 6 innate innate JJ cord-010092-uftc8inx 1410 7 immune immune JJ cord-010092-uftc8inx 1410 8 cell cell NN cord-010092-uftc8inx 1410 9 activation activation NN cord-010092-uftc8inx 1410 10 or or CC cord-010092-uftc8inx 1410 11 tolerance tolerance NN cord-010092-uftc8inx 1410 12 by by IN cord-010092-uftc8inx 1410 13 controlling control VBG cord-010092-uftc8inx 1410 14 the the DT cord-010092-uftc8inx 1410 15 maturation maturation NN cord-010092-uftc8inx 1410 16 of of IN cord-010092-uftc8inx 1410 17 the the DT cord-010092-uftc8inx 1410 18 circulating circulate VBG cord-010092-uftc8inx 1410 19 pro pro JJ cord-010092-uftc8inx 1410 20 - - JJ cord-010092-uftc8inx 1410 21 inflammatory inflammatory JJ cord-010092-uftc8inx 1410 22 subset subset NN cord-010092-uftc8inx 1410 23 of of IN cord-010092-uftc8inx 1410 24 dendritic dendritic JJ cord-010092-uftc8inx 1410 25 cells cell NNS cord-010092-uftc8inx 1410 26 ( ( -LRB- cord-010092-uftc8inx 1410 27 DCs DCs NNP cord-010092-uftc8inx 1410 28 ) ) -RRB- cord-010092-uftc8inx 1410 29 . . . cord-010092-uftc8inx 1411 1 These these DT cord-010092-uftc8inx 1411 2 cells cell NNS cord-010092-uftc8inx 1411 3 are be VBP cord-010092-uftc8inx 1411 4 potent potent JJ cord-010092-uftc8inx 1411 5 inducers inducer NNS cord-010092-uftc8inx 1411 6 of of IN cord-010092-uftc8inx 1411 7 primary primary JJ cord-010092-uftc8inx 1411 8 antigen antigen NN cord-010092-uftc8inx 1411 9 - - HYPH cord-010092-uftc8inx 1411 10 specific specific JJ cord-010092-uftc8inx 1411 11 T t NN cord-010092-uftc8inx 1411 12 cell cell NN cord-010092-uftc8inx 1411 13 responses response NNS cord-010092-uftc8inx 1411 14 , , , cord-010092-uftc8inx 1411 15 produce produce VBP cord-010092-uftc8inx 1411 16 TNF TNF NNP cord-010092-uftc8inx 1411 17 - - : cord-010092-uftc8inx 1411 18 a a NNP cord-010092-uftc8inx 1411 19 when when WRB cord-010092-uftc8inx 1411 20 stimulated stimulate VBN cord-010092-uftc8inx 1411 21 by by IN cord-010092-uftc8inx 1411 22 LPS LPS NNP cord-010092-uftc8inx 1411 23 and and CC cord-010092-uftc8inx 1411 24 are be VBP cord-010092-uftc8inx 1411 25 the the DT cord-010092-uftc8inx 1411 26 principal principal JJ cord-010092-uftc8inx 1411 27 IL-12p70-producing IL-12p70-producing NNP cord-010092-uftc8inx 1411 28 cells cell NNS cord-010092-uftc8inx 1411 29 among among IN cord-010092-uftc8inx 1411 30 leukocytes leukocyte NNS cord-010092-uftc8inx 1411 31 . . . cord-010092-uftc8inx 1412 1 The the DT cord-010092-uftc8inx 1412 2 pro pro JJ cord-010092-uftc8inx 1412 3 - - JJ cord-010092-uftc8inx 1412 4 inflammatory inflammatory JJ cord-010092-uftc8inx 1412 5 capacity capacity NN cord-010092-uftc8inx 1412 6 of of IN cord-010092-uftc8inx 1412 7 circulating circulate VBG cord-010092-uftc8inx 1412 8 DCs DCs NNP cord-010092-uftc8inx 1412 9 is be VBZ cord-010092-uftc8inx 1412 10 controlled control VBN cord-010092-uftc8inx 1412 11 by by IN cord-010092-uftc8inx 1412 12 RBCs rbc NNS cord-010092-uftc8inx 1412 13 that that WDT cord-010092-uftc8inx 1412 14 are be VBP cord-010092-uftc8inx 1412 15 able able JJ cord-010092-uftc8inx 1412 16 to to TO cord-010092-uftc8inx 1412 17 inhibit inhibit VB cord-010092-uftc8inx 1412 18 their -PRON- PRP$ cord-010092-uftc8inx 1412 19 maturation maturation NN cord-010092-uftc8inx 1412 20 and and CC cord-010092-uftc8inx 1412 21 IL-12 IL-12 NNP cord-010092-uftc8inx 1412 22 production production NN cord-010092-uftc8inx 1412 23 . . . cord-010092-uftc8inx 1413 1 In in IN cord-010092-uftc8inx 1413 2 diseases disease NNS cord-010092-uftc8inx 1413 3 characterized characterize VBN cord-010092-uftc8inx 1413 4 by by IN cord-010092-uftc8inx 1413 5 local local JJ cord-010092-uftc8inx 1413 6 Th1 th1 CD cord-010092-uftc8inx 1413 7 inflammatory inflammatory JJ cord-010092-uftc8inx 1413 8 response response NN cord-010092-uftc8inx 1413 9 such such JJ cord-010092-uftc8inx 1413 10 as as IN cord-010092-uftc8inx 1413 11 psoriasis psoriasis NN cord-010092-uftc8inx 1413 12 vulgaris vulgaris NN cord-010092-uftc8inx 1413 13 and and CC cord-010092-uftc8inx 1413 14 rheumatoid rheumatoid NN cord-010092-uftc8inx 1413 15 arthritis arthritis NN cord-010092-uftc8inx 1413 16 , , , cord-010092-uftc8inx 1413 17 pro pro JJ cord-010092-uftc8inx 1413 18 - - JJ cord-010092-uftc8inx 1413 19 inflammatory inflammatory JJ cord-010092-uftc8inx 1413 20 DCs dc NNS cord-010092-uftc8inx 1413 21 play play VBP cord-010092-uftc8inx 1413 22 a a DT cord-010092-uftc8inx 1413 23 role role NN cord-010092-uftc8inx 1413 24 in in IN cord-010092-uftc8inx 1413 25 the the DT cord-010092-uftc8inx 1413 26 induction induction NN cord-010092-uftc8inx 1413 27 and and CC cord-010092-uftc8inx 1413 28 perpetuation perpetuation NN cord-010092-uftc8inx 1413 29 of of IN cord-010092-uftc8inx 1413 30 inflammation inflammation NN cord-010092-uftc8inx 1413 31 . . . cord-010092-uftc8inx 1414 1 Collectively collectively RB cord-010092-uftc8inx 1414 2 , , , cord-010092-uftc8inx 1414 3 literature literature NN cord-010092-uftc8inx 1414 4 data datum NNS cord-010092-uftc8inx 1414 5 indicate indicate VBP cord-010092-uftc8inx 1414 6 that that IN cord-010092-uftc8inx 1414 7 RBCs rbc NNS cord-010092-uftc8inx 1414 8 exert exert VB cord-010092-uftc8inx 1414 9 important important JJ cord-010092-uftc8inx 1414 10 modulatory modulatory JJ cord-010092-uftc8inx 1414 11 functions function NNS cord-010092-uftc8inx 1414 12 that that WDT cord-010092-uftc8inx 1414 13 may may MD cord-010092-uftc8inx 1414 14 result result VB cord-010092-uftc8inx 1414 15 in in IN cord-010092-uftc8inx 1414 16 immune immune JJ cord-010092-uftc8inx 1414 17 activation activation NN cord-010092-uftc8inx 1414 18 or or CC cord-010092-uftc8inx 1414 19 quiescence quiescence NN cord-010092-uftc8inx 1414 20 , , , cord-010092-uftc8inx 1414 21 depending depend VBG cord-010092-uftc8inx 1414 22 on on IN cord-010092-uftc8inx 1414 23 the the DT cord-010092-uftc8inx 1414 24 environmental environmental JJ cord-010092-uftc8inx 1414 25 conditions condition NNS cord-010092-uftc8inx 1414 26 . . . cord-010092-uftc8inx 1415 1 When when WRB cord-010092-uftc8inx 1415 2 RBCs rbc NNS cord-010092-uftc8inx 1415 3 encounter encounter VBP cord-010092-uftc8inx 1415 4 a a DT cord-010092-uftc8inx 1415 5 microenvironment microenvironment NN cord-010092-uftc8inx 1415 6 characterized characterize VBN cord-010092-uftc8inx 1415 7 by by IN cord-010092-uftc8inx 1415 8 an an DT cord-010092-uftc8inx 1415 9 intense intense JJ cord-010092-uftc8inx 1415 10 production production NN cord-010092-uftc8inx 1415 11 of of IN cord-010092-uftc8inx 1415 12 ROS ROS NNP cord-010092-uftc8inx 1415 13 , , , cord-010092-uftc8inx 1415 14 the the DT cord-010092-uftc8inx 1415 15 RBC RBC NNP cord-010092-uftc8inx 1415 16 defenses defense NNS cord-010092-uftc8inx 1415 17 get get VBP cord-010092-uftc8inx 1415 18 overwhelmed overwhelmed JJ cord-010092-uftc8inx 1415 19 or or CC cord-010092-uftc8inx 1415 20 are be VBP cord-010092-uftc8inx 1415 21 unable unable JJ cord-010092-uftc8inx 1415 22 to to TO cord-010092-uftc8inx 1415 23 counteract counteract VB cord-010092-uftc8inx 1415 24 the the DT cord-010092-uftc8inx 1415 25 new new JJ cord-010092-uftc8inx 1415 26 pro pro JJ cord-010092-uftc8inx 1415 27 - - JJ cord-010092-uftc8inx 1415 28 oxidant oxidant JJ cord-010092-uftc8inx 1415 29 status status NN cord-010092-uftc8inx 1415 30 and and CC cord-010092-uftc8inx 1415 31 become become VBP cord-010092-uftc8inx 1415 32 themselves -PRON- PRP cord-010092-uftc8inx 1415 33 a a DT cord-010092-uftc8inx 1415 34 source source NN cord-010092-uftc8inx 1415 35 of of IN cord-010092-uftc8inx 1415 36 ROS ROS NNP cord-010092-uftc8inx 1415 37 , , , cord-010092-uftc8inx 1415 38 which which WDT cord-010092-uftc8inx 1415 39 cause cause VBP cord-010092-uftc8inx 1415 40 the the DT cord-010092-uftc8inx 1415 41 generation generation NN cord-010092-uftc8inx 1415 42 of of IN cord-010092-uftc8inx 1415 43 senescent senescent JJ cord-010092-uftc8inx 1415 44 signals signal NNS cord-010092-uftc8inx 1415 45 on on IN cord-010092-uftc8inx 1415 46 RBCs rbc NNS cord-010092-uftc8inx 1415 47 . . . cord-010092-uftc8inx 1416 1 The the DT cord-010092-uftc8inx 1416 2 major major JJ cord-010092-uftc8inx 1416 3 feature feature NN cord-010092-uftc8inx 1416 4 of of IN cord-010092-uftc8inx 1416 5 oxidized oxidize VBN cord-010092-uftc8inx 1416 6 RBCs rbc NNS cord-010092-uftc8inx 1416 7 is be VBZ cord-010092-uftc8inx 1416 8 the the DT cord-010092-uftc8inx 1416 9 clustering clustering NN cord-010092-uftc8inx 1416 10 and/or and/or CC cord-010092-uftc8inx 1416 11 the the DT cord-010092-uftc8inx 1416 12 breakdown breakdown NN cord-010092-uftc8inx 1416 13 of of IN cord-010092-uftc8inx 1416 14 Band Band NNP cord-010092-uftc8inx 1416 15 3 3 CD cord-010092-uftc8inx 1416 16 . . . cord-010092-uftc8inx 1417 1 Other other JJ cord-010092-uftc8inx 1417 2 features feature NNS cord-010092-uftc8inx 1417 3 are be VBP cord-010092-uftc8inx 1417 4 the the DT cord-010092-uftc8inx 1417 5 complexation complexation NN cord-010092-uftc8inx 1417 6 of of IN cord-010092-uftc8inx 1417 7 Hb Hb NNP cord-010092-uftc8inx 1417 8 with with IN cord-010092-uftc8inx 1417 9 spectrin spectrin NNP cord-010092-uftc8inx 1417 10 , , , cord-010092-uftc8inx 1417 11 the the DT cord-010092-uftc8inx 1417 12 loss loss NN cord-010092-uftc8inx 1417 13 of of IN cord-010092-uftc8inx 1417 14 glycophorin glycophorin NNP cord-010092-uftc8inx 1417 15 A A NNP cord-010092-uftc8inx 1417 16 , , , cord-010092-uftc8inx 1417 17 the the DT cord-010092-uftc8inx 1417 18 externalization externalization NN cord-010092-uftc8inx 1417 19 of of IN cord-010092-uftc8inx 1417 20 phosphatidylserine phosphatidylserine NN cord-010092-uftc8inx 1417 21 and and CC cord-010092-uftc8inx 1417 22 the the DT cord-010092-uftc8inx 1417 23 reduction reduction NN cord-010092-uftc8inx 1417 24 of of IN cord-010092-uftc8inx 1417 25 the the DT cord-010092-uftc8inx 1417 26 " " `` cord-010092-uftc8inx 1417 27 marker marker NN cord-010092-uftc8inx 1417 28 of of IN cord-010092-uftc8inx 1417 29 self self NN cord-010092-uftc8inx 1417 30 " " '' cord-010092-uftc8inx 1417 31 integrin integrin NN cord-010092-uftc8inx 1417 32 - - HYPH cord-010092-uftc8inx 1417 33 associated associate VBN cord-010092-uftc8inx 1417 34 protein protein NN cord-010092-uftc8inx 1417 35 CD47 CD47 NNP cord-010092-uftc8inx 1417 36 . . . cord-010092-uftc8inx 1418 1 A a DT cord-010092-uftc8inx 1418 2 similar similar JJ cord-010092-uftc8inx 1418 3 senescence senescence NN cord-010092-uftc8inx 1418 4 phenotype phenotype NN cord-010092-uftc8inx 1418 5 has have VBZ cord-010092-uftc8inx 1418 6 been be VBN cord-010092-uftc8inx 1418 7 documented document VBN cord-010092-uftc8inx 1418 8 in in IN cord-010092-uftc8inx 1418 9 RBCs rbc NNS cord-010092-uftc8inx 1418 10 during during IN cord-010092-uftc8inx 1418 11 the the DT cord-010092-uftc8inx 1418 12 storage storage NN cord-010092-uftc8inx 1418 13 period period NN cord-010092-uftc8inx 1418 14 . . . cord-010092-uftc8inx 1419 1 Oxidized oxidize VBN cord-010092-uftc8inx 1419 2 , , , cord-010092-uftc8inx 1419 3 senescent senescent JJ cord-010092-uftc8inx 1419 4 or or CC cord-010092-uftc8inx 1419 5 stored store VBN cord-010092-uftc8inx 1419 6 RBCs rbc NNS cord-010092-uftc8inx 1419 7 , , , cord-010092-uftc8inx 1419 8 due due IN cord-010092-uftc8inx 1419 9 to to IN cord-010092-uftc8inx 1419 10 surface surface NN cord-010092-uftc8inx 1419 11 antigen antigen NN cord-010092-uftc8inx 1419 12 modification modification NN cord-010092-uftc8inx 1419 13 and and CC cord-010092-uftc8inx 1419 14 to to IN cord-010092-uftc8inx 1419 15 the the DT cord-010092-uftc8inx 1419 16 release release NN cord-010092-uftc8inx 1419 17 of of IN cord-010092-uftc8inx 1419 18 pro pro JJ cord-010092-uftc8inx 1419 19 - - JJ cord-010092-uftc8inx 1419 20 inflammatory inflammatory JJ cord-010092-uftc8inx 1419 21 molecules molecule NNS cord-010092-uftc8inx 1419 22 , , , cord-010092-uftc8inx 1419 23 fail fail VBP cord-010092-uftc8inx 1419 24 to to TO cord-010092-uftc8inx 1419 25 control control VB cord-010092-uftc8inx 1419 26 immune immune JJ cord-010092-uftc8inx 1419 27 cell cell NN cord-010092-uftc8inx 1419 28 homeostasis homeostasis NN cord-010092-uftc8inx 1419 29 thus thus RB cord-010092-uftc8inx 1419 30 contributing contribute VBG cord-010092-uftc8inx 1419 31 to to IN cord-010092-uftc8inx 1419 32 the the DT cord-010092-uftc8inx 1419 33 perpetuation perpetuation NN cord-010092-uftc8inx 1419 34 of of IN cord-010092-uftc8inx 1419 35 inflammation inflammation NN cord-010092-uftc8inx 1419 36 and and CC cord-010092-uftc8inx 1419 37 to to IN cord-010092-uftc8inx 1419 38 the the DT cord-010092-uftc8inx 1419 39 pathogenesis pathogenesis NN cord-010092-uftc8inx 1419 40 of of IN cord-010092-uftc8inx 1419 41 immune immune NN cord-010092-uftc8inx 1419 42 - - HYPH cord-010092-uftc8inx 1419 43 mediated mediate VBN cord-010092-uftc8inx 1419 44 diseases disease NNS cord-010092-uftc8inx 1419 45 associated associate VBN cord-010092-uftc8inx 1419 46 to to IN cord-010092-uftc8inx 1419 47 oxidative oxidative JJ cord-010092-uftc8inx 1419 48 stress stress NN cord-010092-uftc8inx 1419 49 , , , cord-010092-uftc8inx 1419 50 such such JJ cord-010092-uftc8inx 1419 51 as as IN cord-010092-uftc8inx 1419 52 autoimmune autoimmune JJ cord-010092-uftc8inx 1419 53 diseases disease NNS cord-010092-uftc8inx 1419 54 and and CC cord-010092-uftc8inx 1419 55 atherosclerosis atherosclerosis NN cord-010092-uftc8inx 1419 56 . . . cord-010092-uftc8inx 1420 1 Our -PRON- PRP$ cord-010092-uftc8inx 1420 2 research research NN cord-010092-uftc8inx 1420 3 group group NN cord-010092-uftc8inx 1420 4 demonstrated demonstrate VBD cord-010092-uftc8inx 1420 5 that that IN cord-010092-uftc8inx 1420 6 RBCs rbc NNS cord-010092-uftc8inx 1420 7 from from IN cord-010092-uftc8inx 1420 8 patients patient NNS cord-010092-uftc8inx 1420 9 with with IN cord-010092-uftc8inx 1420 10 carotid carotid JJ cord-010092-uftc8inx 1420 11 atherosclerosis atherosclerosis NN cord-010092-uftc8inx 1420 12 presented present VBD cord-010092-uftc8inx 1420 13 a a DT cord-010092-uftc8inx 1420 14 senescent senescent JJ cord-010092-uftc8inx 1420 15 phenotype phenotype NN cord-010092-uftc8inx 1420 16 similar similar JJ cord-010092-uftc8inx 1420 17 to to IN cord-010092-uftc8inx 1420 18 that that DT cord-010092-uftc8inx 1420 19 acquired acquire VBN cord-010092-uftc8inx 1420 20 by by IN cord-010092-uftc8inx 1420 21 RBCs rbc NNS cord-010092-uftc8inx 1420 22 from from IN cord-010092-uftc8inx 1420 23 healthy healthy JJ cord-010092-uftc8inx 1420 24 subjects subject NNS cord-010092-uftc8inx 1420 25 following follow VBG cord-010092-uftc8inx 1420 26 to to IN cord-010092-uftc8inx 1420 27 in in FW cord-010092-uftc8inx 1420 28 vitro vitro FW cord-010092-uftc8inx 1420 29 oxidation oxidation NN cord-010092-uftc8inx 1420 30 . . . cord-010092-uftc8inx 1421 1 Oxidized oxidized JJ cord-010092-uftc8inx 1421 2 erythrocytes erythrocyte NNS cord-010092-uftc8inx 1421 3 fail fail VBP cord-010092-uftc8inx 1421 4 to to TO cord-010092-uftc8inx 1421 5 control control VB cord-010092-uftc8inx 1421 6 T t NN cord-010092-uftc8inx 1421 7 lymphocytes lymphocyte NNS cord-010092-uftc8inx 1422 1 apoptosis apoptosis NN cord-010092-uftc8inx 1422 2 and and CC cord-010092-uftc8inx 1422 3 lipopolysaccharide lipopolysaccharide NN cord-010092-uftc8inx 1422 4 - - HYPH cord-010092-uftc8inx 1422 5 induced induce VBN cord-010092-uftc8inx 1422 6 monocyte monocyte NNP cord-010092-uftc8inx 1422 7 - - HYPH cord-010092-uftc8inx 1422 8 derived derive VBN cord-010092-uftc8inx 1422 9 DC DC NNP cord-010092-uftc8inx 1422 10 maturation maturation NN cord-010092-uftc8inx 1422 11 , , , cord-010092-uftc8inx 1422 12 thus thus RB cord-010092-uftc8inx 1422 13 representing represent VBG cord-010092-uftc8inx 1422 14 dangerous dangerous JJ cord-010092-uftc8inx 1422 15 signals signal NNS cord-010092-uftc8inx 1422 16 for for IN cord-010092-uftc8inx 1422 17 adaptive adaptive JJ cord-010092-uftc8inx 1422 18 and and CC cord-010092-uftc8inx 1422 19 innate innate JJ cord-010092-uftc8inx 1422 20 immunity immunity NN cord-010092-uftc8inx 1422 21 and and CC cord-010092-uftc8inx 1422 22 contributing contribute VBG cord-010092-uftc8inx 1422 23 to to IN cord-010092-uftc8inx 1422 24 the the DT cord-010092-uftc8inx 1422 25 pathogenesis pathogenesis NN cord-010092-uftc8inx 1422 26 of of IN cord-010092-uftc8inx 1422 27 atherosclerosis atherosclerosis NN cord-010092-uftc8inx 1422 28 . . . cord-010092-uftc8inx 1423 1 In in IN cord-010092-uftc8inx 1423 2 conclusion conclusion NN cord-010092-uftc8inx 1423 3 , , , cord-010092-uftc8inx 1423 4 the the DT cord-010092-uftc8inx 1423 5 crosstalk crosstalk NN cord-010092-uftc8inx 1423 6 between between IN cord-010092-uftc8inx 1423 7 RBCs rbc NNS cord-010092-uftc8inx 1423 8 and and CC cord-010092-uftc8inx 1423 9 the the DT cord-010092-uftc8inx 1423 10 immune immune JJ cord-010092-uftc8inx 1423 11 system system NN cord-010092-uftc8inx 1423 12 represents represent VBZ cord-010092-uftc8inx 1423 13 a a DT cord-010092-uftc8inx 1423 14 mechanism mechanism NN cord-010092-uftc8inx 1423 15 to to TO cord-010092-uftc8inx 1423 16 maintain maintain VB cord-010092-uftc8inx 1423 17 immunological immunological JJ cord-010092-uftc8inx 1423 18 homeostasis homeostasis NN cord-010092-uftc8inx 1423 19 . . . cord-010092-uftc8inx 1424 1 However however RB cord-010092-uftc8inx 1424 2 , , , cord-010092-uftc8inx 1424 3 in in IN cord-010092-uftc8inx 1424 4 high high JJ cord-010092-uftc8inx 1424 5 oxidative oxidative JJ cord-010092-uftc8inx 1424 6 stress stress NN cord-010092-uftc8inx 1424 7 conditions condition NNS cord-010092-uftc8inx 1424 8 , , , cord-010092-uftc8inx 1424 9 that that WDT cord-010092-uftc8inx 1424 10 can can MD cord-010092-uftc8inx 1424 11 take take VB cord-010092-uftc8inx 1424 12 place place NN cord-010092-uftc8inx 1424 13 during during IN cord-010092-uftc8inx 1424 14 a a DT cord-010092-uftc8inx 1424 15 prolonged prolong VBN cord-010092-uftc8inx 1424 16 storage storage NN cord-010092-uftc8inx 1424 17 period period NN cord-010092-uftc8inx 1424 18 or or CC cord-010092-uftc8inx 1424 19 in in IN cord-010092-uftc8inx 1424 20 particular particular JJ cord-010092-uftc8inx 1424 21 diseases disease NNS cord-010092-uftc8inx 1424 22 , , , cord-010092-uftc8inx 1424 23 RBCs rbc NNS cord-010092-uftc8inx 1424 24 can can MD cord-010092-uftc8inx 1424 25 acquire acquire VB cord-010092-uftc8inx 1424 26 a a DT cord-010092-uftc8inx 1424 27 pro pro JJ cord-010092-uftc8inx 1424 28 - - JJ cord-010092-uftc8inx 1424 29 oxidant oxidant JJ cord-010092-uftc8inx 1424 30 behaviour behaviour NN cord-010092-uftc8inx 1424 31 and and CC cord-010092-uftc8inx 1424 32 lose lose VB cord-010092-uftc8inx 1424 33 their -PRON- PRP$ cord-010092-uftc8inx 1424 34 functional functional JJ cord-010092-uftc8inx 1424 35 and and CC cord-010092-uftc8inx 1424 36 homeostatic homeostatic JJ cord-010092-uftc8inx 1424 37 features feature NNS cord-010092-uftc8inx 1424 38 . . . cord-010092-uftc8inx 1425 1 By by IN cord-010092-uftc8inx 1425 2 interfering interfere VBG cord-010092-uftc8inx 1425 3 in in IN cord-010092-uftc8inx 1425 4 immune immune JJ cord-010092-uftc8inx 1425 5 system system NN cord-010092-uftc8inx 1425 6 homeostasis homeostasis NN cord-010092-uftc8inx 1425 7 , , , cord-010092-uftc8inx 1425 8 RBCs rbc NNS cord-010092-uftc8inx 1425 9 become become VBP cord-010092-uftc8inx 1425 10 a a DT cord-010092-uftc8inx 1425 11 potential potential JJ cord-010092-uftc8inx 1425 12 tool tool NN cord-010092-uftc8inx 1425 13 that that WDT cord-010092-uftc8inx 1425 14 can can MD cord-010092-uftc8inx 1425 15 be be VB cord-010092-uftc8inx 1425 16 manipulated manipulate VBN cord-010092-uftc8inx 1425 17 to to TO cord-010092-uftc8inx 1425 18 improve improve VB cord-010092-uftc8inx 1425 19 or or CC cord-010092-uftc8inx 1425 20 reverse reverse VB cord-010092-uftc8inx 1425 21 pathological pathological JJ cord-010092-uftc8inx 1425 22 situations situation NNS cord-010092-uftc8inx 1425 23 characterized characterize VBN cord-010092-uftc8inx 1425 24 by by IN cord-010092-uftc8inx 1425 25 anomalies anomaly NNS cord-010092-uftc8inx 1425 26 in in IN cord-010092-uftc8inx 1425 27 the the DT cord-010092-uftc8inx 1425 28 control control NN cord-010092-uftc8inx 1425 29 of of IN cord-010092-uftc8inx 1425 30 adaptive adaptive JJ cord-010092-uftc8inx 1425 31 and and CC cord-010092-uftc8inx 1425 32 innate innate JJ cord-010092-uftc8inx 1425 33 immunity immunity NN cord-010092-uftc8inx 1425 34 . . . cord-010092-uftc8inx 1426 1 Transfusion transfusion NN cord-010092-uftc8inx 1426 2 therapy therapy NN cord-010092-uftc8inx 1426 3 remains remain VBZ cord-010092-uftc8inx 1426 4 an an DT cord-010092-uftc8inx 1426 5 important important JJ cord-010092-uftc8inx 1426 6 treatment treatment NN cord-010092-uftc8inx 1426 7 modality modality NN cord-010092-uftc8inx 1426 8 for for IN cord-010092-uftc8inx 1426 9 patients patient NNS cord-010092-uftc8inx 1426 10 with with IN cord-010092-uftc8inx 1426 11 sickle sickle NN cord-010092-uftc8inx 1426 12 cell cell NN cord-010092-uftc8inx 1426 13 disease disease NN cord-010092-uftc8inx 1426 14 ( ( -LRB- cord-010092-uftc8inx 1426 15 SCD SCD NNP cord-010092-uftc8inx 1426 16 ) ) -RRB- cord-010092-uftc8inx 1426 17 . . . cord-010092-uftc8inx 1427 1 Transfusions transfusion NNS cord-010092-uftc8inx 1427 2 are be VBP cord-010092-uftc8inx 1427 3 given give VBN cord-010092-uftc8inx 1427 4 to to TO cord-010092-uftc8inx 1427 5 lower lower VB cord-010092-uftc8inx 1427 6 the the DT cord-010092-uftc8inx 1427 7 percentage percentage NN cord-010092-uftc8inx 1427 8 of of IN cord-010092-uftc8inx 1427 9 circulating circulate VBG cord-010092-uftc8inx 1427 10 sickle sickle NN cord-010092-uftc8inx 1427 11 RBCs rbc NNS cord-010092-uftc8inx 1427 12 , , , cord-010092-uftc8inx 1427 13 and and CC cord-010092-uftc8inx 1427 14 to to TO cord-010092-uftc8inx 1427 15 decrease decrease VB cord-010092-uftc8inx 1427 16 blood blood NN cord-010092-uftc8inx 1427 17 viscosity viscosity NN cord-010092-uftc8inx 1427 18 and and CC cord-010092-uftc8inx 1427 19 have have VBP cord-010092-uftc8inx 1427 20 been be VBN cord-010092-uftc8inx 1427 21 shown show VBN cord-010092-uftc8inx 1427 22 in in IN cord-010092-uftc8inx 1427 23 clinical clinical JJ cord-010092-uftc8inx 1427 24 trials trial NNS cord-010092-uftc8inx 1427 25 to to TO cord-010092-uftc8inx 1427 26 reduce reduce VB cord-010092-uftc8inx 1427 27 the the DT cord-010092-uftc8inx 1427 28 risk risk NN cord-010092-uftc8inx 1427 29 of of IN cord-010092-uftc8inx 1427 30 stroke stroke NN cord-010092-uftc8inx 1427 31 by by IN cord-010092-uftc8inx 1427 32 90 90 CD cord-010092-uftc8inx 1427 33 % % NN cord-010092-uftc8inx 1427 34 . . . cord-010092-uftc8inx 1428 1 However however RB cord-010092-uftc8inx 1428 2 , , , cord-010092-uftc8inx 1428 3 many many JJ cord-010092-uftc8inx 1428 4 indications indication NNS cord-010092-uftc8inx 1428 5 for for IN cord-010092-uftc8inx 1428 6 transfusion transfusion NN cord-010092-uftc8inx 1428 7 in in IN cord-010092-uftc8inx 1428 8 SCD SCD NNP cord-010092-uftc8inx 1428 9 remain remain VBP cord-010092-uftc8inx 1428 10 controversial controversial JJ cord-010092-uftc8inx 1428 11 partly partly RB cord-010092-uftc8inx 1428 12 due due JJ cord-010092-uftc8inx 1428 13 to to IN cord-010092-uftc8inx 1428 14 insufficient insufficient JJ cord-010092-uftc8inx 1428 15 randomized randomized JJ cord-010092-uftc8inx 1428 16 clinical clinical JJ cord-010092-uftc8inx 1428 17 trials trial NNS cord-010092-uftc8inx 1428 18 data datum NNS cord-010092-uftc8inx 1428 19 and and CC cord-010092-uftc8inx 1428 20 in in IN cord-010092-uftc8inx 1428 21 part part NN cord-010092-uftc8inx 1428 22 because because IN cord-010092-uftc8inx 1428 23 of of IN cord-010092-uftc8inx 1428 24 our -PRON- PRP$ cord-010092-uftc8inx 1428 25 limited limited JJ cord-010092-uftc8inx 1428 26 understanding understanding NN cord-010092-uftc8inx 1428 27 of of IN cord-010092-uftc8inx 1428 28 the the DT cord-010092-uftc8inx 1428 29 complex complex JJ cord-010092-uftc8inx 1428 30 pathologic pathologic JJ cord-010092-uftc8inx 1428 31 networks network NNS cord-010092-uftc8inx 1428 32 leading lead VBG cord-010092-uftc8inx 1428 33 to to IN cord-010092-uftc8inx 1428 34 diverse diverse JJ cord-010092-uftc8inx 1428 35 disease disease NN cord-010092-uftc8inx 1428 36 complications complication NNS cord-010092-uftc8inx 1428 37 in in IN cord-010092-uftc8inx 1428 38 SCD SCD NNP cord-010092-uftc8inx 1428 39 despite despite IN cord-010092-uftc8inx 1428 40 the the DT cord-010092-uftc8inx 1428 41 common common JJ cord-010092-uftc8inx 1428 42 single single JJ cord-010092-uftc8inx 1428 43 mutation mutation NN cord-010092-uftc8inx 1428 44 . . . cord-010092-uftc8inx 1429 1 Similarly similarly RB cord-010092-uftc8inx 1429 2 , , , cord-010092-uftc8inx 1429 3 we -PRON- PRP cord-010092-uftc8inx 1429 4 have have VBP cord-010092-uftc8inx 1429 5 incomplete incomplete JJ cord-010092-uftc8inx 1429 6 mechanistic mechanistic JJ cord-010092-uftc8inx 1429 7 understanding understanding NN cord-010092-uftc8inx 1429 8 of of IN cord-010092-uftc8inx 1429 9 why why WRB cord-010092-uftc8inx 1429 10 chronic chronic JJ cord-010092-uftc8inx 1429 11 transfusion transfusion NN cord-010092-uftc8inx 1429 12 protocols protocol NNS cord-010092-uftc8inx 1429 13 must must MD cord-010092-uftc8inx 1429 14 be be VB cord-010092-uftc8inx 1429 15 continued continue VBN cord-010092-uftc8inx 1429 16 for for IN cord-010092-uftc8inx 1429 17 those those DT cord-010092-uftc8inx 1429 18 indications indication NNS cord-010092-uftc8inx 1429 19 supported support VBN cord-010092-uftc8inx 1429 20 by by IN cord-010092-uftc8inx 1429 21 clinical clinical JJ cord-010092-uftc8inx 1429 22 data datum NNS cord-010092-uftc8inx 1429 23 . . . cord-010092-uftc8inx 1430 1 The the DT cord-010092-uftc8inx 1430 2 beneficial beneficial JJ cord-010092-uftc8inx 1430 3 effects effect NNS cord-010092-uftc8inx 1430 4 of of IN cord-010092-uftc8inx 1430 5 transfusion transfusion NN cord-010092-uftc8inx 1430 6 therapy therapy NN cord-010092-uftc8inx 1430 7 in in IN cord-010092-uftc8inx 1430 8 SCD SCD NNP cord-010092-uftc8inx 1430 9 need need VBP cord-010092-uftc8inx 1430 10 to to TO cord-010092-uftc8inx 1430 11 also also RB cord-010092-uftc8inx 1430 12 be be VB cord-010092-uftc8inx 1430 13 weighed weigh VBN cord-010092-uftc8inx 1430 14 against against IN cord-010092-uftc8inx 1430 15 potential potential JJ cord-010092-uftc8inx 1430 16 transfusion transfusion NN cord-010092-uftc8inx 1430 17 risks risk NNS cord-010092-uftc8inx 1430 18 including include VBG cord-010092-uftc8inx 1430 19 alloimmunization alloimmunization NN cord-010092-uftc8inx 1430 20 associated associate VBN cord-010092-uftc8inx 1430 21 with with IN cord-010092-uftc8inx 1430 22 lifethreatening lifethreatening JJ cord-010092-uftc8inx 1430 23 delayed delayed JJ cord-010092-uftc8inx 1430 24 transfusion transfusion NN cord-010092-uftc8inx 1430 25 reactions reaction NNS cord-010092-uftc8inx 1430 26 , , , cord-010092-uftc8inx 1430 27 increased increase VBN cord-010092-uftc8inx 1430 28 iron iron NN cord-010092-uftc8inx 1430 29 stores store NNS cord-010092-uftc8inx 1430 30 associated associate VBN cord-010092-uftc8inx 1430 31 with with IN cord-010092-uftc8inx 1430 32 increased increase VBN cord-010092-uftc8inx 1430 33 oxidative oxidative JJ cord-010092-uftc8inx 1430 34 stress stress NN cord-010092-uftc8inx 1430 35 and and CC cord-010092-uftc8inx 1430 36 exposure exposure NN cord-010092-uftc8inx 1430 37 to to IN cord-010092-uftc8inx 1430 38 infectious infectious JJ cord-010092-uftc8inx 1430 39 agents agent NNS cord-010092-uftc8inx 1430 40 . . . cord-010092-uftc8inx 1431 1 We -PRON- PRP cord-010092-uftc8inx 1431 2 believe believe VBP cord-010092-uftc8inx 1431 3 that that IN cord-010092-uftc8inx 1431 4 a a DT cord-010092-uftc8inx 1431 5 deeper deep JJR cord-010092-uftc8inx 1431 6 understanding understanding NN cord-010092-uftc8inx 1431 7 of of IN cord-010092-uftc8inx 1431 8 the the DT cord-010092-uftc8inx 1431 9 benefits benefit NNS cord-010092-uftc8inx 1431 10 as as RB cord-010092-uftc8inx 1431 11 well well RB cord-010092-uftc8inx 1431 12 as as IN cord-010092-uftc8inx 1431 13 harmful harmful JJ cord-010092-uftc8inx 1431 14 effects effect NNS cord-010092-uftc8inx 1431 15 of of IN cord-010092-uftc8inx 1431 16 transfusions transfusion NNS cord-010092-uftc8inx 1431 17 is be VBZ cord-010092-uftc8inx 1431 18 crucial crucial JJ cord-010092-uftc8inx 1431 19 to to TO cord-010092-uftc8inx 1431 20 optimize optimize VB cord-010092-uftc8inx 1431 21 our -PRON- PRP$ cord-010092-uftc8inx 1431 22 current current JJ cord-010092-uftc8inx 1431 23 transfusion transfusion NN cord-010092-uftc8inx 1431 24 therapy therapy NN cord-010092-uftc8inx 1431 25 protocols protocol NNS cord-010092-uftc8inx 1431 26 in in IN cord-010092-uftc8inx 1431 27 SCD SCD NNP cord-010092-uftc8inx 1431 28 . . . cord-010092-uftc8inx 1432 1 This this DT cord-010092-uftc8inx 1432 2 knowledge knowledge NN cord-010092-uftc8inx 1432 3 may may MD cord-010092-uftc8inx 1432 4 provide provide VB cord-010092-uftc8inx 1432 5 highly highly RB cord-010092-uftc8inx 1432 6 needed need VBN cord-010092-uftc8inx 1432 7 guidance guidance NN cord-010092-uftc8inx 1432 8 , , , cord-010092-uftc8inx 1432 9 which which WDT cord-010092-uftc8inx 1432 10 is be VBZ cord-010092-uftc8inx 1432 11 currently currently RB cord-010092-uftc8inx 1432 12 lacking lack VBG cord-010092-uftc8inx 1432 13 , , , cord-010092-uftc8inx 1432 14 for for IN cord-010092-uftc8inx 1432 15 expansion expansion NN cord-010092-uftc8inx 1432 16 or or CC cord-010092-uftc8inx 1432 17 limiting limit VBG cord-010092-uftc8inx 1432 18 existing exist VBG cord-010092-uftc8inx 1432 19 indications indication NNS cord-010092-uftc8inx 1432 20 for for IN cord-010092-uftc8inx 1432 21 chronic chronic JJ cord-010092-uftc8inx 1432 22 transfusions transfusion NNS cord-010092-uftc8inx 1432 23 in in IN cord-010092-uftc8inx 1432 24 SCD SCD NNP cord-010092-uftc8inx 1432 25 . . . cord-010092-uftc8inx 1433 1 3D 3D NNP cord-010092-uftc8inx 1433 2 - - HYPH cord-010092-uftc8inx 1433 3 S12 S12 NNP cord-010092-uftc8inx 1433 4 - - HYPH cord-010092-uftc8inx 1433 5 02 02 CD cord-010092-uftc8inx 1433 6 TREATMENT treatment NN cord-010092-uftc8inx 1433 7 OF of IN cord-010092-uftc8inx 1433 8 THALASSAEMIA THALASSAEMIA NNP cord-010092-uftc8inx 1433 9 Department Department NNP cord-010092-uftc8inx 1433 10 of of IN cord-010092-uftc8inx 1433 11 Pediatric Pediatric NNP cord-010092-uftc8inx 1433 12 Hematology Hematology NNP cord-010092-uftc8inx 1433 13 , , , cord-010092-uftc8inx 1433 14 Ege Ege NNP cord-010092-uftc8inx 1433 15 University University NNP cord-010092-uftc8inx 1433 16 , , , cord-010092-uftc8inx 1433 17 Faculty Faculty NNP cord-010092-uftc8inx 1433 18 of of IN cord-010092-uftc8inx 1433 19 Medicine Medicine NNP cord-010092-uftc8inx 1433 20 , , , cord-010092-uftc8inx 1434 1 Bornova/ Bornova/ NNP cord-010092-uftc8inx 1434 2 Izmir Izmir NNP cord-010092-uftc8inx 1434 3 , , , cord-010092-uftc8inx 1434 4 Turkey Turkey NNP cord-010092-uftc8inx 1434 5 Thalassaemia Thalassaemia NNP cord-010092-uftc8inx 1434 6 is be VBZ cord-010092-uftc8inx 1434 7 a a DT cord-010092-uftc8inx 1434 8 devastating devastating JJ cord-010092-uftc8inx 1434 9 blood blood NN cord-010092-uftc8inx 1434 10 disease disease NN cord-010092-uftc8inx 1434 11 with with IN cord-010092-uftc8inx 1434 12 a a DT cord-010092-uftc8inx 1434 13 significant significant JJ cord-010092-uftc8inx 1434 14 worldwide worldwide JJ cord-010092-uftc8inx 1434 15 burden burden NN cord-010092-uftc8inx 1434 16 . . . cord-010092-uftc8inx 1435 1 Annually annually RB cord-010092-uftc8inx 1435 2 , , , cord-010092-uftc8inx 1435 3 60,000 60,000 CD cord-010092-uftc8inx 1435 4 children child NNS cord-010092-uftc8inx 1435 5 are be VBP cord-010092-uftc8inx 1435 6 born bear VBN cord-010092-uftc8inx 1435 7 with with IN cord-010092-uftc8inx 1435 8 a a DT cord-010092-uftc8inx 1435 9 major major JJ cord-010092-uftc8inx 1435 10 thalassemia thalassemia NN cord-010092-uftc8inx 1435 11 . . . cord-010092-uftc8inx 1436 1 Life life NN cord-010092-uftc8inx 1436 2 - - HYPH cord-010092-uftc8inx 1436 3 time time NN cord-010092-uftc8inx 1436 4 RBCC RBCC NNP cord-010092-uftc8inx 1436 5 transfusions transfusion NNS cord-010092-uftc8inx 1436 6 and and CC cord-010092-uftc8inx 1436 7 iron iron NN cord-010092-uftc8inx 1436 8 chelation chelation NN cord-010092-uftc8inx 1436 9 remain remain VBP cord-010092-uftc8inx 1436 10 standard standard JJ cord-010092-uftc8inx 1436 11 of of IN cord-010092-uftc8inx 1436 12 care care NN cord-010092-uftc8inx 1436 13 treatment treatment NN cord-010092-uftc8inx 1436 14 in in IN cord-010092-uftc8inx 1436 15 thalassaemia thalassaemia NN cord-010092-uftc8inx 1436 16 . . . cord-010092-uftc8inx 1437 1 Transfusion transfusion NN cord-010092-uftc8inx 1437 2 therapy therapy NN cord-010092-uftc8inx 1437 3 still still RB cord-010092-uftc8inx 1437 4 account account VBP cord-010092-uftc8inx 1437 5 for for IN cord-010092-uftc8inx 1437 6 significant significant JJ cord-010092-uftc8inx 1437 7 iron iron NN cord-010092-uftc8inx 1437 8 overload overload NN cord-010092-uftc8inx 1437 9 related relate VBN cord-010092-uftc8inx 1437 10 morbidity morbidity NN cord-010092-uftc8inx 1437 11 and and CC cord-010092-uftc8inx 1437 12 mortality mortality NN cord-010092-uftc8inx 1437 13 despite despite IN cord-010092-uftc8inx 1437 14 chelation chelation NN cord-010092-uftc8inx 1437 15 therapy therapy NN cord-010092-uftc8inx 1437 16 which which WDT cord-010092-uftc8inx 1437 17 is be VBZ cord-010092-uftc8inx 1437 18 associated associate VBN cord-010092-uftc8inx 1437 19 with with IN cord-010092-uftc8inx 1437 20 poor poor JJ cord-010092-uftc8inx 1437 21 adherence adherence NN cord-010092-uftc8inx 1437 22 , , , cord-010092-uftc8inx 1437 23 safety safety NN cord-010092-uftc8inx 1437 24 concerns concern NNS cord-010092-uftc8inx 1437 25 and and CC cord-010092-uftc8inx 1437 26 varied varied JJ cord-010092-uftc8inx 1437 27 efficacy efficacy NN cord-010092-uftc8inx 1437 28 . . . cord-010092-uftc8inx 1438 1 Higher high JJR cord-010092-uftc8inx 1438 2 risk risk NN cord-010092-uftc8inx 1438 3 for for IN cord-010092-uftc8inx 1438 4 transfusion transfusion NN cord-010092-uftc8inx 1438 5 transmitted transmit VBN cord-010092-uftc8inx 1438 6 infections infection NNS cord-010092-uftc8inx 1438 7 ( ( -LRB- cord-010092-uftc8inx 1438 8 TTIs tti NNS cord-010092-uftc8inx 1438 9 ) ) -RRB- cord-010092-uftc8inx 1438 10 exists exist VBZ cord-010092-uftc8inx 1438 11 for for IN cord-010092-uftc8inx 1438 12 thalassemia thalassemia NN cord-010092-uftc8inx 1438 13 patients patient NNS cord-010092-uftc8inx 1438 14 whose whose WP$ cord-010092-uftc8inx 1438 15 transfusion transfusion NN cord-010092-uftc8inx 1438 16 exposure exposure NN cord-010092-uftc8inx 1438 17 sustains sustain VBZ cord-010092-uftc8inx 1438 18 lifelong lifelong JJ cord-010092-uftc8inx 1438 19 . . . cord-010092-uftc8inx 1439 1 Although although IN cord-010092-uftc8inx 1439 2 , , , cord-010092-uftc8inx 1439 3 the the DT cord-010092-uftc8inx 1439 4 risk risk NN cord-010092-uftc8inx 1439 5 of of IN cord-010092-uftc8inx 1439 6 transmission transmission NN cord-010092-uftc8inx 1439 7 for for IN cord-010092-uftc8inx 1439 8 traditional traditional JJ cord-010092-uftc8inx 1439 9 viruses virus NNS cord-010092-uftc8inx 1439 10 is be VBZ cord-010092-uftc8inx 1439 11 exceedingly exceedingly RB cord-010092-uftc8inx 1439 12 rare rare JJ cord-010092-uftc8inx 1439 13 in in IN cord-010092-uftc8inx 1439 14 the the DT cord-010092-uftc8inx 1439 15 modern modern JJ cord-010092-uftc8inx 1439 16 era era NN cord-010092-uftc8inx 1439 17 , , , cord-010092-uftc8inx 1439 18 emerging emerge VBG cord-010092-uftc8inx 1439 19 infectious infectious JJ cord-010092-uftc8inx 1439 20 diseases disease NNS cord-010092-uftc8inx 1439 21 continue continue VBP cord-010092-uftc8inx 1439 22 to to TO cord-010092-uftc8inx 1439 23 be be VB cord-010092-uftc8inx 1439 24 recognized recognize VBN cord-010092-uftc8inx 1439 25 as as IN cord-010092-uftc8inx 1439 26 potential potential JJ cord-010092-uftc8inx 1439 27 threats threat NNS cord-010092-uftc8inx 1439 28 to to IN cord-010092-uftc8inx 1439 29 transfusion transfusion NN cord-010092-uftc8inx 1439 30 safety safety NN cord-010092-uftc8inx 1439 31 . . . cord-010092-uftc8inx 1440 1 The the DT cord-010092-uftc8inx 1440 2 inadequacy inadequacy NN cord-010092-uftc8inx 1440 3 of of IN cord-010092-uftc8inx 1440 4 blood blood NN cord-010092-uftc8inx 1440 5 safety safety NN cord-010092-uftc8inx 1440 6 points point NNS cord-010092-uftc8inx 1440 7 to to IN cord-010092-uftc8inx 1440 8 the the DT cord-010092-uftc8inx 1440 9 necessity necessity NN cord-010092-uftc8inx 1440 10 for for IN cord-010092-uftc8inx 1440 11 an an DT cord-010092-uftc8inx 1440 12 additional additional JJ cord-010092-uftc8inx 1440 13 layer layer NN cord-010092-uftc8inx 1440 14 of of IN cord-010092-uftc8inx 1440 15 security security NN cord-010092-uftc8inx 1440 16 for for IN cord-010092-uftc8inx 1440 17 the the DT cord-010092-uftc8inx 1440 18 blood blood NN cord-010092-uftc8inx 1440 19 supply supply NN cord-010092-uftc8inx 1440 20 in in IN cord-010092-uftc8inx 1440 21 the the DT cord-010092-uftc8inx 1440 22 developing develop VBG cord-010092-uftc8inx 1440 23 world world NN cord-010092-uftc8inx 1440 24 . . . cord-010092-uftc8inx 1441 1 Pathogen pathogen NN cord-010092-uftc8inx 1441 2 reduction reduction NN cord-010092-uftc8inx 1441 3 technologies technology NNS cord-010092-uftc8inx 1441 4 for for IN cord-010092-uftc8inx 1441 5 RBCC RBCC NNP cord-010092-uftc8inx 1441 6 may may MD cord-010092-uftc8inx 1441 7 imply imply VB cord-010092-uftc8inx 1441 8 a a DT cord-010092-uftc8inx 1441 9 proactive proactive JJ cord-010092-uftc8inx 1441 10 , , , cord-010092-uftc8inx 1441 11 more more RBR cord-010092-uftc8inx 1441 12 generalized generalize VBN cord-010092-uftc8inx 1441 13 approach approach NN cord-010092-uftc8inx 1441 14 against against IN cord-010092-uftc8inx 1441 15 new new JJ cord-010092-uftc8inx 1441 16 and and CC cord-010092-uftc8inx 1441 17 re re JJ cord-010092-uftc8inx 1441 18 - - JJ cord-010092-uftc8inx 1441 19 emerging emerge VBG cord-010092-uftc8inx 1441 20 pathogens pathogen NNS cord-010092-uftc8inx 1441 21 in in IN cord-010092-uftc8inx 1441 22 the the DT cord-010092-uftc8inx 1441 23 developed develop VBN cord-010092-uftc8inx 1441 24 world world NN cord-010092-uftc8inx 1441 25 and and CC cord-010092-uftc8inx 1441 26 may may MD cord-010092-uftc8inx 1441 27 be be VB cord-010092-uftc8inx 1441 28 an an DT cord-010092-uftc8inx 1441 29 ultimate ultimate JJ cord-010092-uftc8inx 1441 30 safeguard safeguard NN cord-010092-uftc8inx 1441 31 for for IN cord-010092-uftc8inx 1441 32 transfusion transfusion NN cord-010092-uftc8inx 1441 33 safety safety NN cord-010092-uftc8inx 1441 34 in in IN cord-010092-uftc8inx 1441 35 the the DT cord-010092-uftc8inx 1441 36 developing develop VBG cord-010092-uftc8inx 1441 37 countries country NNS cord-010092-uftc8inx 1441 38 . . . cord-010092-uftc8inx 1442 1 RBC RBC NNP cord-010092-uftc8inx 1442 2 alloimmunization alloimmunization NN cord-010092-uftc8inx 1442 3 may may MD cord-010092-uftc8inx 1442 4 become become VB cord-010092-uftc8inx 1442 5 a a DT cord-010092-uftc8inx 1442 6 major major JJ cord-010092-uftc8inx 1442 7 challenge challenge NN cord-010092-uftc8inx 1442 8 in in IN cord-010092-uftc8inx 1442 9 thalassaemia thalassaemia NN cord-010092-uftc8inx 1442 10 management management NN cord-010092-uftc8inx 1442 11 . . . cord-010092-uftc8inx 1443 1 Prevention prevention NN cord-010092-uftc8inx 1443 2 is be VBZ cord-010092-uftc8inx 1443 3 the the DT cord-010092-uftc8inx 1443 4 key key NN cord-010092-uftc8inx 1443 5 reducing reduce VBG cord-010092-uftc8inx 1443 6 the the DT cord-010092-uftc8inx 1443 7 burden burden NN cord-010092-uftc8inx 1443 8 of of IN cord-010092-uftc8inx 1443 9 alloimmunization alloimmunization NN cord-010092-uftc8inx 1443 10 . . . cord-010092-uftc8inx 1444 1 While while IN cord-010092-uftc8inx 1444 2 the the DT cord-010092-uftc8inx 1444 3 recommendation recommendation NN cord-010092-uftc8inx 1444 4 is be VBZ cord-010092-uftc8inx 1444 5 to to TO cord-010092-uftc8inx 1444 6 transfuse transfuse VB cord-010092-uftc8inx 1444 7 thalassaemic thalassaemic JJ cord-010092-uftc8inx 1444 8 patients patient NNS cord-010092-uftc8inx 1444 9 with with IN cord-010092-uftc8inx 1444 10 C C NNP cord-010092-uftc8inx 1444 11 / / SYM cord-010092-uftc8inx 1444 12 c c NN cord-010092-uftc8inx 1444 13 , , , cord-010092-uftc8inx 1444 14 E E NNP cord-010092-uftc8inx 1444 15 / / SYM cord-010092-uftc8inx 1444 16 e e XX cord-010092-uftc8inx 1444 17 , , , cord-010092-uftc8inx 1444 18 Kell Kell NNP cord-010092-uftc8inx 1444 19 compatible compatible JJ cord-010092-uftc8inx 1444 20 blood blood NN cord-010092-uftc8inx 1444 21 , , , cord-010092-uftc8inx 1444 22 it -PRON- PRP cord-010092-uftc8inx 1444 23 is be VBZ cord-010092-uftc8inx 1444 24 not not RB cord-010092-uftc8inx 1444 25 universally universally RB cord-010092-uftc8inx 1444 26 practiced practice VBN cord-010092-uftc8inx 1444 27 . . . cord-010092-uftc8inx 1445 1 Extended extended JJ cord-010092-uftc8inx 1445 2 molecular molecular JJ cord-010092-uftc8inx 1445 3 RBC RBC NNP cord-010092-uftc8inx 1445 4 typing typing NN cord-010092-uftc8inx 1445 5 may may MD cord-010092-uftc8inx 1445 6 be be VB cord-010092-uftc8inx 1445 7 an an DT cord-010092-uftc8inx 1445 8 appropriate appropriate JJ cord-010092-uftc8inx 1445 9 adjunctive adjunctive JJ cord-010092-uftc8inx 1445 10 test test NN cord-010092-uftc8inx 1445 11 in in IN cord-010092-uftc8inx 1445 12 addition addition NN cord-010092-uftc8inx 1445 13 to to IN cord-010092-uftc8inx 1445 14 serological serological JJ cord-010092-uftc8inx 1445 15 typing typing NN cord-010092-uftc8inx 1445 16 before before IN cord-010092-uftc8inx 1445 17 embarking embark VBG cord-010092-uftc8inx 1445 18 on on IN cord-010092-uftc8inx 1445 19 transfusion transfusion NN cord-010092-uftc8inx 1445 20 therapy therapy NN cord-010092-uftc8inx 1445 21 . . . cord-010092-uftc8inx 1446 1 If if IN cord-010092-uftc8inx 1446 2 a a DT cord-010092-uftc8inx 1446 3 complete complete JJ cord-010092-uftc8inx 1446 4 RBC RBC NNP cord-010092-uftc8inx 1446 5 antigen antigen NN cord-010092-uftc8inx 1446 6 profile profile NN cord-010092-uftc8inx 1446 7 has have VBZ cord-010092-uftc8inx 1446 8 not not RB cord-010092-uftc8inx 1446 9 yet yet RB cord-010092-uftc8inx 1446 10 been be VBN cord-010092-uftc8inx 1446 11 performed perform VBN cord-010092-uftc8inx 1446 12 in in IN cord-010092-uftc8inx 1446 13 an an DT cord-010092-uftc8inx 1446 14 alloimmunized alloimmunized JJ cord-010092-uftc8inx 1446 15 patient patient NN cord-010092-uftc8inx 1446 16 , , , cord-010092-uftc8inx 1446 17 genotyping genotyping NN cord-010092-uftc8inx 1446 18 is be VBZ cord-010092-uftc8inx 1446 19 the the DT cord-010092-uftc8inx 1446 20 only only JJ cord-010092-uftc8inx 1446 21 option option NN cord-010092-uftc8inx 1446 22 for for IN cord-010092-uftc8inx 1446 23 accurate accurate JJ cord-010092-uftc8inx 1446 24 detection detection NN cord-010092-uftc8inx 1446 25 of of IN cord-010092-uftc8inx 1446 26 RBC RBC NNP cord-010092-uftc8inx 1446 27 antigens antigen NNS cord-010092-uftc8inx 1446 28 that that WDT cord-010092-uftc8inx 1446 29 may may MD cord-010092-uftc8inx 1446 30 guide guide VB cord-010092-uftc8inx 1446 31 the the DT cord-010092-uftc8inx 1446 32 antibody antibody NN cord-010092-uftc8inx 1446 33 identification identification NN cord-010092-uftc8inx 1446 34 . . . cord-010092-uftc8inx 1447 1 Allogeneic allogeneic IN cord-010092-uftc8inx 1447 2 stem stem VBP cord-010092-uftc8inx 1447 3 cell cell NN cord-010092-uftc8inx 1447 4 transplantation transplantation NN cord-010092-uftc8inx 1447 5 ( ( -LRB- cord-010092-uftc8inx 1447 6 A A NNP cord-010092-uftc8inx 1447 7 - - HYPH cord-010092-uftc8inx 1447 8 SCT SCT NNP cord-010092-uftc8inx 1447 9 ) ) -RRB- cord-010092-uftc8inx 1447 10 is be VBZ cord-010092-uftc8inx 1447 11 the the DT cord-010092-uftc8inx 1447 12 only only RB cord-010092-uftc8inx 1447 13 available available JJ cord-010092-uftc8inx 1447 14 curative curative JJ cord-010092-uftc8inx 1447 15 therapy therapy NN cord-010092-uftc8inx 1447 16 in in IN cord-010092-uftc8inx 1447 17 children child NNS cord-010092-uftc8inx 1447 18 with with IN cord-010092-uftc8inx 1447 19 HLA HLA NNP cord-010092-uftc8inx 1447 20 matched match VBN cord-010092-uftc8inx 1447 21 sibling sibling NN cord-010092-uftc8inx 1447 22 which which WDT cord-010092-uftc8inx 1447 23 is be VBZ cord-010092-uftc8inx 1447 24 available available JJ cord-010092-uftc8inx 1447 25 to to IN cord-010092-uftc8inx 1447 26 approximately approximately RB cord-010092-uftc8inx 1447 27 20 20 CD cord-010092-uftc8inx 1447 28 % % NN cord-010092-uftc8inx 1447 29 patients patient NNS cord-010092-uftc8inx 1447 30 . . . cord-010092-uftc8inx 1448 1 In in IN cord-010092-uftc8inx 1448 2 the the DT cord-010092-uftc8inx 1448 3 absence absence NN cord-010092-uftc8inx 1448 4 of of IN cord-010092-uftc8inx 1448 5 MSD MSD NNP cord-010092-uftc8inx 1448 6 , , , cord-010092-uftc8inx 1448 7 MUD mud NN cord-010092-uftc8inx 1448 8 transplant transplant NN cord-010092-uftc8inx 1448 9 with with IN cord-010092-uftc8inx 1448 10 high high JJ cord-010092-uftc8inx 1448 11 compatibility compatibility NN cord-010092-uftc8inx 1448 12 criteria criterion NNS cord-010092-uftc8inx 1448 13 has have VBZ cord-010092-uftc8inx 1448 14 still still RB cord-010092-uftc8inx 1448 15 limited limited JJ cord-010092-uftc8inx 1448 16 experience experience NN cord-010092-uftc8inx 1448 17 . . . cord-010092-uftc8inx 1449 1 Mismatch mismatch NN cord-010092-uftc8inx 1449 2 related relate VBN cord-010092-uftc8inx 1449 3 , , , cord-010092-uftc8inx 1449 4 cord cord NN cord-010092-uftc8inx 1449 5 blood blood NN cord-010092-uftc8inx 1449 6 and and CC cord-010092-uftc8inx 1449 7 haploidentical haploidentical JJ cord-010092-uftc8inx 1449 8 donor donor NN cord-010092-uftc8inx 1449 9 SCTs sct NNS cord-010092-uftc8inx 1449 10 are be VBP cord-010092-uftc8inx 1449 11 considered consider VBN cord-010092-uftc8inx 1449 12 experimental experimental JJ cord-010092-uftc8inx 1449 13 . . . cord-010092-uftc8inx 1450 1 A a LS cord-010092-uftc8inx 1450 2 - - HYPH cord-010092-uftc8inx 1450 3 SCT SCT NNP cord-010092-uftc8inx 1450 4 carries carry VBZ cord-010092-uftc8inx 1450 5 a a DT cord-010092-uftc8inx 1450 6 substantial substantial JJ cord-010092-uftc8inx 1450 7 risk risk NN cord-010092-uftc8inx 1450 8 of of IN cord-010092-uftc8inx 1450 9 SAEs SAEs NNP cord-010092-uftc8inx 1450 10 and and CC cord-010092-uftc8inx 1450 11 mortality mortality NN cord-010092-uftc8inx 1450 12 , , , cord-010092-uftc8inx 1450 13 both both CC cord-010092-uftc8inx 1450 14 increasing increase VBG cord-010092-uftc8inx 1450 15 with with IN cord-010092-uftc8inx 1450 16 recipient recipient NN cord-010092-uftc8inx 1450 17 age age NN cord-010092-uftc8inx 1450 18 and and CC cord-010092-uftc8inx 1450 19 disease disease NN cord-010092-uftc8inx 1450 20 severity severity NN cord-010092-uftc8inx 1450 21 . . . cord-010092-uftc8inx 1451 1 DFS DFS NNP cord-010092-uftc8inx 1451 2 is be VBZ cord-010092-uftc8inx 1451 3 88 88 CD cord-010092-uftc8inx 1451 4 % % NN cord-010092-uftc8inx 1451 5 in in IN cord-010092-uftc8inx 1451 6 paediatric paediatric JJ cord-010092-uftc8inx 1451 7 and and CC cord-010092-uftc8inx 1451 8 65 65 CD cord-010092-uftc8inx 1451 9 % % NN cord-010092-uftc8inx 1451 10 in in IN cord-010092-uftc8inx 1451 11 adults adult NNS cord-010092-uftc8inx 1451 12 . . . cord-010092-uftc8inx 1452 1 Gene gene NN cord-010092-uftc8inx 1452 2 therapy therapy NN cord-010092-uftc8inx 1452 3 for for IN cord-010092-uftc8inx 1452 4 correction correction NN cord-010092-uftc8inx 1452 5 of of IN cord-010092-uftc8inx 1452 6 the the DT cord-010092-uftc8inx 1452 7 a a DT cord-010092-uftc8inx 1452 8 - - HYPH cord-010092-uftc8inx 1452 9 globin globin NN cord-010092-uftc8inx 1452 10 chain chain NN cord-010092-uftc8inx 1452 11 imbalance imbalance NN cord-010092-uftc8inx 1452 12 overcomes overcome VBZ cord-010092-uftc8inx 1452 13 the the DT cord-010092-uftc8inx 1452 14 problems problem NNS cord-010092-uftc8inx 1452 15 of of IN cord-010092-uftc8inx 1452 16 donor donor NN cord-010092-uftc8inx 1452 17 availability availability NN cord-010092-uftc8inx 1452 18 and and CC cord-010092-uftc8inx 1452 19 immunologic immunologic JJ cord-010092-uftc8inx 1452 20 complications complication NNS cord-010092-uftc8inx 1452 21 associated associate VBN cord-010092-uftc8inx 1452 22 with with IN cord-010092-uftc8inx 1452 23 A a DT cord-010092-uftc8inx 1452 24 - - HYPH cord-010092-uftc8inx 1452 25 SCT sct NN cord-010092-uftc8inx 1452 26 . . . cord-010092-uftc8inx 1453 1 Multicenter multicenter JJ cord-010092-uftc8inx 1453 2 clinical clinical JJ cord-010092-uftc8inx 1453 3 studies study NNS cord-010092-uftc8inx 1453 4 on on IN cord-010092-uftc8inx 1453 5 gene gene NN cord-010092-uftc8inx 1453 6 addition addition NN cord-010092-uftc8inx 1453 7 therapy therapy NN cord-010092-uftc8inx 1453 8 by by IN cord-010092-uftc8inx 1453 9 using use VBG cord-010092-uftc8inx 1453 10 self self NN cord-010092-uftc8inx 1453 11 - - HYPH cord-010092-uftc8inx 1453 12 inactivating inactivate VBG cord-010092-uftc8inx 1453 13 lentiviral lentiviral JJ cord-010092-uftc8inx 1453 14 vector vector NN cord-010092-uftc8inx 1453 15 are be VBP cord-010092-uftc8inx 1453 16 currently currently RB cord-010092-uftc8inx 1453 17 underway underway JJ cord-010092-uftc8inx 1453 18 . . . cord-010092-uftc8inx 1454 1 Recently recently RB cord-010092-uftc8inx 1454 2 , , , cord-010092-uftc8inx 1454 3 gene gene NN cord-010092-uftc8inx 1454 4 editing editing NN cord-010092-uftc8inx 1454 5 by by IN cord-010092-uftc8inx 1454 6 either either DT cord-010092-uftc8inx 1454 7 gene gene NN cord-010092-uftc8inx 1454 8 disruption disruption NN cord-010092-uftc8inx 1454 9 or or CC cord-010092-uftc8inx 1454 10 gene gene NN cord-010092-uftc8inx 1454 11 correction correction NN cord-010092-uftc8inx 1454 12 emerged emerge VBD cord-010092-uftc8inx 1454 13 as as IN cord-010092-uftc8inx 1454 14 a a DT cord-010092-uftc8inx 1454 15 potential potential JJ cord-010092-uftc8inx 1454 16 alternative alternative NN cord-010092-uftc8inx 1454 17 to to IN cord-010092-uftc8inx 1454 18 gene gene NN cord-010092-uftc8inx 1454 19 addition addition NN cord-010092-uftc8inx 1454 20 therapy therapy NN cord-010092-uftc8inx 1454 21 in in IN cord-010092-uftc8inx 1454 22 beta beta JJ cord-010092-uftc8inx 1454 23 - - HYPH cord-010092-uftc8inx 1454 24 thalassaemia thalassaemia NN cord-010092-uftc8inx 1454 25 . . . cord-010092-uftc8inx 1455 1 A a DT cord-010092-uftc8inx 1455 2 new new JJ cord-010092-uftc8inx 1455 3 era era NN cord-010092-uftc8inx 1455 4 of of IN cord-010092-uftc8inx 1455 5 novel novel JJ cord-010092-uftc8inx 1455 6 therapeutics therapeutic NNS cord-010092-uftc8inx 1455 7 is be VBZ cord-010092-uftc8inx 1455 8 unfolding unfold VBG cord-010092-uftc8inx 1455 9 in in IN cord-010092-uftc8inx 1455 10 thalassemia thalassemia NN cord-010092-uftc8inx 1455 11 management management NN cord-010092-uftc8inx 1455 12 . . . cord-010092-uftc8inx 1456 1 Several several JJ cord-010092-uftc8inx 1456 2 targets target NNS cord-010092-uftc8inx 1456 3 have have VBP cord-010092-uftc8inx 1456 4 been be VBN cord-010092-uftc8inx 1456 5 identified identify VBN cord-010092-uftc8inx 1456 6 that that WDT cord-010092-uftc8inx 1456 7 can can MD cord-010092-uftc8inx 1456 8 improve improve VB cord-010092-uftc8inx 1456 9 alpha alpha NN cord-010092-uftc8inx 1456 10 / / SYM cord-010092-uftc8inx 1456 11 beta beta NN cord-010092-uftc8inx 1456 12 chains chain NNS cord-010092-uftc8inx 1456 13 imbalance imbalance NN cord-010092-uftc8inx 1456 14 , , , cord-010092-uftc8inx 1456 15 ineffective ineffective JJ cord-010092-uftc8inx 1456 16 erythropoiesis erythropoiesis NN cord-010092-uftc8inx 1456 17 , , , cord-010092-uftc8inx 1456 18 or or CC cord-010092-uftc8inx 1456 19 iron iron NN cord-010092-uftc8inx 1456 20 dysregulation dysregulation NN cord-010092-uftc8inx 1456 21 and and CC cord-010092-uftc8inx 1456 22 a a DT cord-010092-uftc8inx 1456 23 number number NN cord-010092-uftc8inx 1456 24 of of IN cord-010092-uftc8inx 1456 25 those those DT cord-010092-uftc8inx 1456 26 now now RB cord-010092-uftc8inx 1456 27 have have VBP cord-010092-uftc8inx 1456 28 agents agent NNS cord-010092-uftc8inx 1456 29 in in IN cord-010092-uftc8inx 1456 30 preclinical preclinical JJ cord-010092-uftc8inx 1456 31 and and CC cord-010092-uftc8inx 1456 32 clinical clinical JJ cord-010092-uftc8inx 1456 33 development development NN cord-010092-uftc8inx 1456 34 . . . cord-010092-uftc8inx 1457 1 Hydroxyurea Hydroxyurea NNP cord-010092-uftc8inx 1457 2 may may MD cord-010092-uftc8inx 1457 3 improve improve VB cord-010092-uftc8inx 1457 4 globin globin NN cord-010092-uftc8inx 1457 5 chain chain NN cord-010092-uftc8inx 1457 6 imbalance imbalance NN cord-010092-uftc8inx 1457 7 and and CC cord-010092-uftc8inx 1457 8 be be VB cord-010092-uftc8inx 1457 9 beneficial beneficial JJ cord-010092-uftc8inx 1457 10 for for IN cord-010092-uftc8inx 1457 11 reducing reduce VBG cord-010092-uftc8inx 1457 12 or or CC cord-010092-uftc8inx 1457 13 omitting omit VBG cord-010092-uftc8inx 1457 14 transfusion transfusion NN cord-010092-uftc8inx 1457 15 requirement requirement NN cord-010092-uftc8inx 1457 16 in in IN cord-010092-uftc8inx 1457 17 selected select VBN cord-010092-uftc8inx 1457 18 group group NN cord-010092-uftc8inx 1457 19 of of IN cord-010092-uftc8inx 1457 20 patients patient NNS cord-010092-uftc8inx 1457 21 . . . cord-010092-uftc8inx 1458 1 Ruxolitinib Ruxolitinib NNP cord-010092-uftc8inx 1458 2 has have VBZ cord-010092-uftc8inx 1458 3 shown show VBN cord-010092-uftc8inx 1458 4 the the DT cord-010092-uftc8inx 1458 5 limited limited JJ cord-010092-uftc8inx 1458 6 effect effect NN cord-010092-uftc8inx 1458 7 on on IN cord-010092-uftc8inx 1458 8 pretransfusion pretransfusion NN cord-010092-uftc8inx 1458 9 haemoglobin haemoglobin NN cord-010092-uftc8inx 1458 10 and and CC cord-010092-uftc8inx 1458 11 reduction reduction NN cord-010092-uftc8inx 1458 12 in in IN cord-010092-uftc8inx 1458 13 transfusion transfusion NN cord-010092-uftc8inx 1458 14 needs need NNS cord-010092-uftc8inx 1458 15 , , , cord-010092-uftc8inx 1458 16 but but CC cord-010092-uftc8inx 1458 17 allowed allow VBD cord-010092-uftc8inx 1458 18 steady steady JJ cord-010092-uftc8inx 1458 19 decrease decrease NN cord-010092-uftc8inx 1458 20 in in IN cord-010092-uftc8inx 1458 21 spleen spleen NN cord-010092-uftc8inx 1458 22 volume volume NN cord-010092-uftc8inx 1458 23 that that WDT cord-010092-uftc8inx 1458 24 may may MD cord-010092-uftc8inx 1458 25 serve serve VB cord-010092-uftc8inx 1458 26 for for IN cord-010092-uftc8inx 1458 27 avoiding avoid VBG cord-010092-uftc8inx 1458 28 splenectomy splenectomy NN cord-010092-uftc8inx 1458 29 in in IN cord-010092-uftc8inx 1458 30 beta beta NN cord-010092-uftc8inx 1458 31 thalassaemia thalassaemia NN cord-010092-uftc8inx 1458 32 . . . cord-010092-uftc8inx 1459 1 Luspatercept Luspatercept NNP cord-010092-uftc8inx 1459 2 may may MD cord-010092-uftc8inx 1459 3 restore restore VB cord-010092-uftc8inx 1459 4 normal normal JJ cord-010092-uftc8inx 1459 5 erythroid erythroid JJ cord-010092-uftc8inx 1459 6 differentiation differentiation NN cord-010092-uftc8inx 1459 7 and and CC cord-010092-uftc8inx 1459 8 improves improve VBZ cord-010092-uftc8inx 1459 9 anaemia anaemia NN cord-010092-uftc8inx 1459 10 and and CC cord-010092-uftc8inx 1459 11 hepcidin hepcidin NNP cord-010092-uftc8inx 1459 12 mimetics mimetics NNPS cord-010092-uftc8inx 1459 13 or or CC cord-010092-uftc8inx 1459 14 TMPRSS6 TMPRSS6 NNP cord-010092-uftc8inx 1459 15 inhibitors inhibitor NNS cord-010092-uftc8inx 1459 16 may may MD cord-010092-uftc8inx 1459 17 modulates modulate VBZ cord-010092-uftc8inx 1459 18 ineffective ineffective JJ cord-010092-uftc8inx 1459 19 erythropoiesis erythropoiesis NN cord-010092-uftc8inx 1459 20 by by IN cord-010092-uftc8inx 1459 21 iron iron NN cord-010092-uftc8inx 1459 22 restriction restriction NN cord-010092-uftc8inx 1459 23 and and CC cord-010092-uftc8inx 1459 24 improves improve VBZ cord-010092-uftc8inx 1459 25 anaemia anaemia NN cord-010092-uftc8inx 1459 26 and and CC cord-010092-uftc8inx 1459 27 organ organ NN cord-010092-uftc8inx 1459 28 iron iron NN cord-010092-uftc8inx 1459 29 loading loading NN cord-010092-uftc8inx 1459 30 . . . cord-010092-uftc8inx 1460 1 Background background NN cord-010092-uftc8inx 1460 2 : : : cord-010092-uftc8inx 1461 1 Thalassaemia thalassaemia JJ cord-010092-uftc8inx 1461 2 major major NN cord-010092-uftc8inx 1461 3 ( ( -LRB- cord-010092-uftc8inx 1461 4 particularly particularly RB cord-010092-uftc8inx 1461 5 b b NN cord-010092-uftc8inx 1461 6 - - HYPH cord-010092-uftc8inx 1461 7 type type NN cord-010092-uftc8inx 1461 8 ) ) -RRB- cord-010092-uftc8inx 1461 9 and and CC cord-010092-uftc8inx 1461 10 Sickle Sickle NNP cord-010092-uftc8inx 1461 11 Cell Cell NNP cord-010092-uftc8inx 1461 12 Disease Disease NNP cord-010092-uftc8inx 1461 13 ( ( -LRB- cord-010092-uftc8inx 1461 14 SCD SCD NNP cord-010092-uftc8inx 1461 15 ) ) -RRB- cord-010092-uftc8inx 1461 16 are be VBP cord-010092-uftc8inx 1461 17 the the DT cord-010092-uftc8inx 1461 18 commonest common JJS cord-010092-uftc8inx 1461 19 clinically clinically RB cord-010092-uftc8inx 1461 20 important important JJ cord-010092-uftc8inx 1461 21 haemoglobinopathies haemoglobinopathy NNS cord-010092-uftc8inx 1461 22 , , , cord-010092-uftc8inx 1461 23 representing represent VBG cord-010092-uftc8inx 1461 24 major major JJ cord-010092-uftc8inx 1461 25 sources source NNS cord-010092-uftc8inx 1461 26 of of IN cord-010092-uftc8inx 1461 27 morbidity morbidity NN cord-010092-uftc8inx 1461 28 . . . cord-010092-uftc8inx 1462 1 Recommended recommend VBN cord-010092-uftc8inx 1462 2 therapy therapy NN cord-010092-uftc8inx 1462 3 is be VBZ cord-010092-uftc8inx 1462 4 regular regular JJ cord-010092-uftc8inx 1462 5 transfusion transfusion NN cord-010092-uftc8inx 1462 6 of of IN cord-010092-uftc8inx 1462 7 safe safe JJ cord-010092-uftc8inx 1462 8 , , , cord-010092-uftc8inx 1462 9 good good JJ cord-010092-uftc8inx 1462 10 quality quality NN cord-010092-uftc8inx 1462 11 blood blood NN cord-010092-uftc8inx 1462 12 , , , cord-010092-uftc8inx 1462 13 and and CC cord-010092-uftc8inx 1462 14 monitoring monitoring NN cord-010092-uftc8inx 1462 15 of of IN cord-010092-uftc8inx 1462 16 related related JJ cord-010092-uftc8inx 1462 17 complications complication NNS cord-010092-uftc8inx 1462 18 . . . cord-010092-uftc8inx 1463 1 Thalassaemia Thalassaemia NNP cord-010092-uftc8inx 1463 2 International International NNP cord-010092-uftc8inx 1463 3 Federation Federation NNP cord-010092-uftc8inx 1463 4 ( ( -LRB- cord-010092-uftc8inx 1463 5 TIF TIF NNP cord-010092-uftc8inx 1463 6 ) ) -RRB- cord-010092-uftc8inx 1463 7 guidelines guideline NNS cord-010092-uftc8inx 1463 8 , , , cord-010092-uftc8inx 1463 9 in in IN cord-010092-uftc8inx 1463 10 place place NN cord-010092-uftc8inx 1463 11 since since IN cord-010092-uftc8inx 1463 12 1987 1987 CD cord-010092-uftc8inx 1463 13 , , , cord-010092-uftc8inx 1463 14 include include VBP cord-010092-uftc8inx 1463 15 strategies strategy NNS cord-010092-uftc8inx 1463 16 for for IN cord-010092-uftc8inx 1463 17 precautionary precautionary JJ cord-010092-uftc8inx 1463 18 measures measure NNS cord-010092-uftc8inx 1463 19 and and CC cord-010092-uftc8inx 1463 20 use use NN cord-010092-uftc8inx 1463 21 of of IN cord-010092-uftc8inx 1463 22 scientific scientific JJ cord-010092-uftc8inx 1463 23 progress progress NN cord-010092-uftc8inx 1463 24 in in IN cord-010092-uftc8inx 1463 25 detection detection NN cord-010092-uftc8inx 1463 26 , , , cord-010092-uftc8inx 1463 27 inactivation inactivation NN cord-010092-uftc8inx 1463 28 and and CC cord-010092-uftc8inx 1463 29 elimination elimination NN cord-010092-uftc8inx 1463 30 of of IN cord-010092-uftc8inx 1463 31 transfusion transfusion NN cord-010092-uftc8inx 1463 32 transmissible transmissible JJ cord-010092-uftc8inx 1463 33 pathogens pathogen NNS cord-010092-uftc8inx 1463 34 . . . cord-010092-uftc8inx 1464 1 Antigen antigen NN cord-010092-uftc8inx 1464 2 - - HYPH cord-010092-uftc8inx 1464 3 matching match VBG cord-010092-uftc8inx 1464 4 strategies strategy NNS cord-010092-uftc8inx 1464 5 to to TO cord-010092-uftc8inx 1464 6 avoid avoid VB cord-010092-uftc8inx 1464 7 alloimmunization alloimmunization NN cord-010092-uftc8inx 1464 8 against against IN cord-010092-uftc8inx 1464 9 RBC RBC NNP cord-010092-uftc8inx 1464 10 antigens antigen NNS cord-010092-uftc8inx 1464 11 and and CC cord-010092-uftc8inx 1464 12 other other JJ cord-010092-uftc8inx 1464 13 measures measure NNS cord-010092-uftc8inx 1464 14 including include VBG cord-010092-uftc8inx 1464 15 haemovigilance haemovigilance NNP cord-010092-uftc8inx 1464 16 are be VBP cord-010092-uftc8inx 1464 17 key key JJ cord-010092-uftc8inx 1464 18 components component NNS cord-010092-uftc8inx 1464 19 for for IN cord-010092-uftc8inx 1464 20 safe safe JJ cord-010092-uftc8inx 1464 21 blood blood NN cord-010092-uftc8inx 1464 22 , , , cord-010092-uftc8inx 1464 23 alongside alongside IN cord-010092-uftc8inx 1464 24 voluntary voluntary JJ cord-010092-uftc8inx 1464 25 , , , cord-010092-uftc8inx 1464 26 non non JJ cord-010092-uftc8inx 1464 27 - - JJ cord-010092-uftc8inx 1464 28 remunerated remunerated JJ cord-010092-uftc8inx 1464 29 blood blood NN cord-010092-uftc8inx 1464 30 donation donation NN cord-010092-uftc8inx 1464 31 and and CC cord-010092-uftc8inx 1464 32 laboratory laboratory NN cord-010092-uftc8inx 1464 33 quality quality NN cord-010092-uftc8inx 1464 34 assurance assurance NN cord-010092-uftc8inx 1464 35 programmes programme NNS cord-010092-uftc8inx 1464 36 . . . cord-010092-uftc8inx 1465 1 Aims aim VBZ cord-010092-uftc8inx 1465 2 : : : cord-010092-uftc8inx 1465 3 We -PRON- PRP cord-010092-uftc8inx 1465 4 present present VBP cord-010092-uftc8inx 1465 5 the the DT cord-010092-uftc8inx 1465 6 contribution contribution NN cord-010092-uftc8inx 1465 7 of of IN cord-010092-uftc8inx 1465 8 TIF TIF NNP cord-010092-uftc8inx 1465 9 and and CC cord-010092-uftc8inx 1465 10 the the DT cord-010092-uftc8inx 1465 11 Greek greek JJ cord-010092-uftc8inx 1465 12 experience experience NN cord-010092-uftc8inx 1465 13 in in IN cord-010092-uftc8inx 1465 14 ensuring ensure VBG cord-010092-uftc8inx 1465 15 safety safety NN cord-010092-uftc8inx 1465 16 and and CC cord-010092-uftc8inx 1465 17 availability availability NN cord-010092-uftc8inx 1465 18 of of IN cord-010092-uftc8inx 1465 19 blood blood NN cord-010092-uftc8inx 1465 20 for for IN cord-010092-uftc8inx 1465 21 thalassaemia thalassaemia NN cord-010092-uftc8inx 1465 22 patients patient NNS cord-010092-uftc8inx 1465 23 applying apply VBG cord-010092-uftc8inx 1465 24 internationally internationally RB cord-010092-uftc8inx 1465 25 accepted accept VBN cord-010092-uftc8inx 1465 26 standards standard NNS cord-010092-uftc8inx 1465 27 and and CC cord-010092-uftc8inx 1465 28 recommendations recommendation NNS cord-010092-uftc8inx 1465 29 . . . cord-010092-uftc8inx 1466 1 Methods method NNS cord-010092-uftc8inx 1466 2 : : : cord-010092-uftc8inx 1466 3 TIF tif NN cord-010092-uftc8inx 1466 4 -a -a . cord-010092-uftc8inx 1467 1 non non JJ cord-010092-uftc8inx 1467 2 - - JJ cord-010092-uftc8inx 1467 3 profit profit JJ cord-010092-uftc8inx 1467 4 , , , cord-010092-uftc8inx 1467 5 patient patient NN cord-010092-uftc8inx 1467 6 - - HYPH cord-010092-uftc8inx 1467 7 driven drive VBN cord-010092-uftc8inx 1467 8 organization organization NN cord-010092-uftc8inx 1467 9 with with IN cord-010092-uftc8inx 1467 10 204 204 CD cord-010092-uftc8inx 1467 11 national national JJ cord-010092-uftc8inx 1467 12 thalassemia thalassemia NN cord-010092-uftc8inx 1467 13 associations association NNS cord-010092-uftc8inx 1467 14 in in IN cord-010092-uftc8inx 1467 15 62 62 CD cord-010092-uftc8inx 1467 16 countries country NNS cord-010092-uftc8inx 1467 17 -promotes -promotes . cord-010092-uftc8inx 1467 18 national national JJ cord-010092-uftc8inx 1467 19 control control NN cord-010092-uftc8inx 1467 20 programmes programme NNS cord-010092-uftc8inx 1467 21 for for IN cord-010092-uftc8inx 1467 22 prevention prevention NN cord-010092-uftc8inx 1467 23 and and CC cord-010092-uftc8inx 1467 24 management management NN cord-010092-uftc8inx 1467 25 contributing contribute VBG cord-010092-uftc8inx 1467 26 to to IN cord-010092-uftc8inx 1467 27 the the DT cord-010092-uftc8inx 1467 28 achievement achievement NN cord-010092-uftc8inx 1467 29 of of IN cord-010092-uftc8inx 1467 30 final final JJ cord-010092-uftc8inx 1467 31 cure cure NN cord-010092-uftc8inx 1467 32 . . . cord-010092-uftc8inx 1468 1 The the DT cord-010092-uftc8inx 1468 2 main main JJ cord-010092-uftc8inx 1468 3 working working NN cord-010092-uftc8inx 1468 4 methods method NNS cord-010092-uftc8inx 1468 5 are be VBP cord-010092-uftc8inx 1468 6 provision provision NN cord-010092-uftc8inx 1468 7 of of IN cord-010092-uftc8inx 1468 8 education education NN cord-010092-uftc8inx 1468 9 , , , cord-010092-uftc8inx 1468 10 expert expert NN cord-010092-uftc8inx 1468 11 support support NN cord-010092-uftc8inx 1468 12 , , , cord-010092-uftc8inx 1468 13 networking networking NN cord-010092-uftc8inx 1468 14 , , , cord-010092-uftc8inx 1468 15 communications communication NNS cord-010092-uftc8inx 1468 16 and and CC cord-010092-uftc8inx 1468 17 projects project NNS cord-010092-uftc8inx 1468 18 to to TO cord-010092-uftc8inx 1468 19 support support VB cord-010092-uftc8inx 1468 20 improvements improvement NNS cord-010092-uftc8inx 1468 21 in in IN cord-010092-uftc8inx 1468 22 the the DT cord-010092-uftc8inx 1468 23 quality quality NN cord-010092-uftc8inx 1468 24 of of IN cord-010092-uftc8inx 1468 25 health health NN cord-010092-uftc8inx 1468 26 , , , cord-010092-uftc8inx 1468 27 social social JJ cord-010092-uftc8inx 1468 28 and and CC cord-010092-uftc8inx 1468 29 other other JJ cord-010092-uftc8inx 1468 30 care care NN cord-010092-uftc8inx 1468 31 . . . cord-010092-uftc8inx 1469 1 In in IN cord-010092-uftc8inx 1469 2 Greece Greece NNP cord-010092-uftc8inx 1469 3 , , , cord-010092-uftc8inx 1469 4 technical technical JJ cord-010092-uftc8inx 1469 5 standards standard NNS cord-010092-uftc8inx 1469 6 for for IN cord-010092-uftc8inx 1469 7 blood blood NN cord-010092-uftc8inx 1469 8 donor donor NN cord-010092-uftc8inx 1469 9 selection selection NN cord-010092-uftc8inx 1469 10 and and CC cord-010092-uftc8inx 1469 11 testing testing NN cord-010092-uftc8inx 1469 12 are be VBP cord-010092-uftc8inx 1469 13 applied apply VBN cord-010092-uftc8inx 1469 14 in in IN cord-010092-uftc8inx 1469 15 compliance compliance NN cord-010092-uftc8inx 1469 16 with with IN cord-010092-uftc8inx 1469 17 Directive Directive NNP cord-010092-uftc8inx 1469 18 2004/33 2004/33 NNP cord-010092-uftc8inx 1469 19 / / SYM cord-010092-uftc8inx 1469 20 EC EC NNP cord-010092-uftc8inx 1469 21 as as RB cord-010092-uftc8inx 1469 22 well well RB cord-010092-uftc8inx 1469 23 as as IN cord-010092-uftc8inx 1469 24 haemovigilance haemovigilance NN cord-010092-uftc8inx 1469 25 programmes programme NNS cord-010092-uftc8inx 1469 26 and and CC cord-010092-uftc8inx 1469 27 traceability traceability NN cord-010092-uftc8inx 1469 28 procedures procedure NNS cord-010092-uftc8inx 1469 29 for for IN cord-010092-uftc8inx 1469 30 recording record VBG cord-010092-uftc8inx 1469 31 adverse adverse JJ cord-010092-uftc8inx 1469 32 reactions reaction NNS cord-010092-uftc8inx 1469 33 and and CC cord-010092-uftc8inx 1469 34 events event NNS cord-010092-uftc8inx 1469 35 associated associate VBN cord-010092-uftc8inx 1469 36 with with IN cord-010092-uftc8inx 1469 37 the the DT cord-010092-uftc8inx 1469 38 transfusion transfusion NN cord-010092-uftc8inx 1469 39 of of IN cord-010092-uftc8inx 1469 40 RBCs rbc NNS cord-010092-uftc8inx 1469 41 ( ( -LRB- cord-010092-uftc8inx 1469 42 Directive Directive NNP cord-010092-uftc8inx 1469 43 2005/61 2005/61 CD cord-010092-uftc8inx 1469 44 / / SYM cord-010092-uftc8inx 1469 45 EC EC NNP cord-010092-uftc8inx 1469 46 ) ) -RRB- cord-010092-uftc8inx 1469 47 . . . cord-010092-uftc8inx 1470 1 Pre pre JJ cord-010092-uftc8inx 1470 2 - - JJ cord-010092-uftc8inx 1470 3 transfusion transfusion NN cord-010092-uftc8inx 1470 4 and and CC cord-010092-uftc8inx 1470 5 transfusion transfusion NN cord-010092-uftc8inx 1470 6 measures measure NNS cord-010092-uftc8inx 1470 7 recommended recommend VBN cord-010092-uftc8inx 1470 8 by by IN cord-010092-uftc8inx 1470 9 the the DT cord-010092-uftc8inx 1470 10 Council Council NNP cord-010092-uftc8inx 1470 11 of of IN cord-010092-uftc8inx 1470 12 Europe Europe NNP cord-010092-uftc8inx 1470 13 are be VBP cord-010092-uftc8inx 1470 14 applied apply VBN cord-010092-uftc8inx 1470 15 . . . cord-010092-uftc8inx 1471 1 In in IN cord-010092-uftc8inx 1471 2 particular particular JJ cord-010092-uftc8inx 1471 3 , , , cord-010092-uftc8inx 1471 4 measures measure NNS cord-010092-uftc8inx 1471 5 for for IN cord-010092-uftc8inx 1471 6 transfusion transfusion NN cord-010092-uftc8inx 1471 7 of of IN cord-010092-uftc8inx 1471 8 " " `` cord-010092-uftc8inx 1471 9 the the DT cord-010092-uftc8inx 1471 10 right right JJ cord-010092-uftc8inx 1471 11 blood blood NN cord-010092-uftc8inx 1471 12 at at IN cord-010092-uftc8inx 1471 13 the the DT cord-010092-uftc8inx 1471 14 right right JJ cord-010092-uftc8inx 1471 15 time time NN cord-010092-uftc8inx 1471 16 for for IN cord-010092-uftc8inx 1471 17 the the DT cord-010092-uftc8inx 1471 18 right right JJ cord-010092-uftc8inx 1471 19 patient patient NN cord-010092-uftc8inx 1471 20 " " '' cord-010092-uftc8inx 1471 21 , , , cord-010092-uftc8inx 1471 22 leucodepletion leucodepletion NNP cord-010092-uftc8inx 1471 23 , , , cord-010092-uftc8inx 1471 24 RBC RBC NNP cord-010092-uftc8inx 1471 25 washing washing NN cord-010092-uftc8inx 1471 26 and and CC cord-010092-uftc8inx 1471 27 accurate accurate JJ cord-010092-uftc8inx 1471 28 cross cross NN cord-010092-uftc8inx 1471 29 - - JJ cord-010092-uftc8inx 1471 30 matching matching JJ cord-010092-uftc8inx 1471 31 and and CC cord-010092-uftc8inx 1471 32 antigen antigen NN cord-010092-uftc8inx 1471 33 and and CC cord-010092-uftc8inx 1471 34 antibody antibody NN cord-010092-uftc8inx 1471 35 screening screening NN cord-010092-uftc8inx 1471 36 for for IN cord-010092-uftc8inx 1471 37 an an DT cord-010092-uftc8inx 1471 38 extended extended JJ cord-010092-uftc8inx 1471 39 matching matching NN cord-010092-uftc8inx 1471 40 policy policy NN cord-010092-uftc8inx 1471 41 are be VBP cord-010092-uftc8inx 1471 42 practised practise VBN cord-010092-uftc8inx 1471 43 . . . cord-010092-uftc8inx 1472 1 Fresh fresh JJ cord-010092-uftc8inx 1472 2 ( ( -LRB- cord-010092-uftc8inx 1472 3 up up IN cord-010092-uftc8inx 1472 4 to to TO cord-010092-uftc8inx 1472 5 15 15 CD cord-010092-uftc8inx 1472 6 days day NNS cord-010092-uftc8inx 1472 7 old old JJ cord-010092-uftc8inx 1472 8 ) ) -RRB- cord-010092-uftc8inx 1472 9 RBCs rbc NNS cord-010092-uftc8inx 1472 10 are be VBP cord-010092-uftc8inx 1472 11 used use VBN cord-010092-uftc8inx 1472 12 . . . cord-010092-uftc8inx 1473 1 Molecular molecular JJ cord-010092-uftc8inx 1473 2 testing testing NN cord-010092-uftc8inx 1473 3 for for IN cord-010092-uftc8inx 1473 4 ABO ABO NNP cord-010092-uftc8inx 1473 5 and and CC cord-010092-uftc8inx 1473 6 Rh Rh NNP cord-010092-uftc8inx 1473 7 D D NNP cord-010092-uftc8inx 1473 8 is be VBZ cord-010092-uftc8inx 1473 9 performed perform VBN cord-010092-uftc8inx 1473 10 in in IN cord-010092-uftc8inx 1473 11 cases case NNS cord-010092-uftc8inx 1473 12 with with IN cord-010092-uftc8inx 1473 13 blood blood NN cord-010092-uftc8inx 1473 14 group group NN cord-010092-uftc8inx 1473 15 discrepancies discrepancy NNS cord-010092-uftc8inx 1473 16 . . . cord-010092-uftc8inx 1474 1 Haemovigilance Haemovigilance NNP cord-010092-uftc8inx 1474 2 in in IN cord-010092-uftc8inx 1474 3 Greece Greece NNP cord-010092-uftc8inx 1474 4 covers cover VBZ cord-010092-uftc8inx 1474 5 95 95 CD cord-010092-uftc8inx 1474 6 % % NN cord-010092-uftc8inx 1474 7 of of IN cord-010092-uftc8inx 1474 8 total total JJ cord-010092-uftc8inx 1474 9 blood blood NN cord-010092-uftc8inx 1474 10 supply supply NN cord-010092-uftc8inx 1474 11 . . . cord-010092-uftc8inx 1475 1 Data datum NNS cord-010092-uftc8inx 1475 2 on on IN cord-010092-uftc8inx 1475 3 TTIs tti NNS cord-010092-uftc8inx 1475 4 in in IN cord-010092-uftc8inx 1475 5 3,067 3,067 CD cord-010092-uftc8inx 1475 6 patients patient NNS cord-010092-uftc8inx 1475 7 with with IN cord-010092-uftc8inx 1475 8 thalassaemia thalassaemia NN cord-010092-uftc8inx 1475 9 and and CC cord-010092-uftc8inx 1475 10 SCD SCD NNP cord-010092-uftc8inx 1475 11 - - HYPH cord-010092-uftc8inx 1475 12 thalassaemia thalassaemia NN cord-010092-uftc8inx 1475 13 in in IN cord-010092-uftc8inx 1475 14 2010 2010 CD cord-010092-uftc8inx 1475 15 - - SYM cord-010092-uftc8inx 1475 16 2017 2017 CD cord-010092-uftc8inx 1475 17 are be VBP cord-010092-uftc8inx 1475 18 analysed analyse VBN cord-010092-uftc8inx 1475 19 . . . cord-010092-uftc8inx 1476 1 Results result NNS cord-010092-uftc8inx 1476 2 : : : cord-010092-uftc8inx 1477 1 TTI TTI NNP cord-010092-uftc8inx 1477 2 prevalence prevalence NN cord-010092-uftc8inx 1477 3 in in IN cord-010092-uftc8inx 1477 4 thalassaemia thalassaemia NN cord-010092-uftc8inx 1477 5 syndromes syndrome NNS cord-010092-uftc8inx 1477 6 was be VBD cord-010092-uftc8inx 1477 7 : : : cord-010092-uftc8inx 1477 8 HBV HBV NNP cord-010092-uftc8inx 1477 9 1.8 1.8 CD cord-010092-uftc8inx 1477 10 % % NN cord-010092-uftc8inx 1477 11 ( ( -LRB- cord-010092-uftc8inx 1477 12 occult occult JJ cord-010092-uftc8inx 1477 13 type type NN cord-010092-uftc8inx 1477 14 1.3 1.3 CD cord-010092-uftc8inx 1477 15 % % NN cord-010092-uftc8inx 1477 16 ) ) -RRB- cord-010092-uftc8inx 1477 17 , , , cord-010092-uftc8inx 1477 18 HCV HCV NNP cord-010092-uftc8inx 1477 19 54 54 CD cord-010092-uftc8inx 1477 20 % % NN cord-010092-uftc8inx 1477 21 , , , cord-010092-uftc8inx 1477 22 HIV HIV NNP cord-010092-uftc8inx 1477 23 0.3 0.3 CD cord-010092-uftc8inx 1477 24 % % NN cord-010092-uftc8inx 1477 25 , , , cord-010092-uftc8inx 1477 26 HTLV HTLV NNP cord-010092-uftc8inx 1477 27 0.8 0.8 CD cord-010092-uftc8inx 1477 28 % % NN cord-010092-uftc8inx 1477 29 , , , cord-010092-uftc8inx 1477 30 WNV WNV NNP cord-010092-uftc8inx 1477 31 0.5 0.5 CD cord-010092-uftc8inx 1477 32 % % NN cord-010092-uftc8inx 1477 33 and and CC cord-010092-uftc8inx 1477 34 HEV HEV NNP cord-010092-uftc8inx 1477 35 3 3 CD cord-010092-uftc8inx 1477 36 % % NN cord-010092-uftc8inx 1477 37 . . . cord-010092-uftc8inx 1478 1 Most most RBS cord-010092-uftc8inx 1478 2 frequent frequent JJ cord-010092-uftc8inx 1478 3 adverse adverse JJ cord-010092-uftc8inx 1478 4 reactions reaction NNS cord-010092-uftc8inx 1478 5 in in IN cord-010092-uftc8inx 1478 6 2015 2015 CD cord-010092-uftc8inx 1478 7 - - SYM cord-010092-uftc8inx 1478 8 17 17 CD cord-010092-uftc8inx 1478 9 were be VBD cord-010092-uftc8inx 1478 10 allergic allergic JJ cord-010092-uftc8inx 1478 11 ( ( -LRB- cord-010092-uftc8inx 1478 12 incidence incidence NN cord-010092-uftc8inx 1478 13 1:854 1:854 CD cord-010092-uftc8inx 1478 14 ) ) -RRB- cord-010092-uftc8inx 1478 15 , , , cord-010092-uftc8inx 1478 16 non non JJ cord-010092-uftc8inx 1478 17 - - JJ cord-010092-uftc8inx 1478 18 haemolytic haemolytic JJ cord-010092-uftc8inx 1478 19 febrile febrile JJ cord-010092-uftc8inx 1478 20 reactions reaction NNS cord-010092-uftc8inx 1478 21 1:2,631 1:2,631 CD cord-010092-uftc8inx 1478 22 , , , cord-010092-uftc8inx 1479 1 " " `` cord-010092-uftc8inx 1479 2 Other other JJ cord-010092-uftc8inx 1479 3 " " '' cord-010092-uftc8inx 1479 4 1:5,883 1:5,883 CD cord-010092-uftc8inx 1479 5 , , , cord-010092-uftc8inx 1479 6 alloimmunisation alloimmunisation NN cord-010092-uftc8inx 1479 7 1:6,667 1:6,667 CD cord-010092-uftc8inx 1479 8 , , , cord-010092-uftc8inx 1479 9 TACO TACO NNP cord-010092-uftc8inx 1479 10 1:100,013 1:100,013 CD cord-010092-uftc8inx 1479 11 , , , cord-010092-uftc8inx 1479 12 TAD tad NN cord-010092-uftc8inx 1479 13 1:50,006 1:50,006 CD cord-010092-uftc8inx 1479 14 , , , cord-010092-uftc8inx 1479 15 TT TT NNP cord-010092-uftc8inx 1479 16 - - HYPH cord-010092-uftc8inx 1479 17 HEV HEV NNP cord-010092-uftc8inx 1479 18 1:100,013 1:100,013 CD cord-010092-uftc8inx 1479 19 . . . cord-010092-uftc8inx 1480 1 Hyperhaemolysis Hyperhaemolysis NNP cord-010092-uftc8inx 1480 2 was be VBD cord-010092-uftc8inx 1480 3 diagnosed diagnose VBN cord-010092-uftc8inx 1480 4 in in IN cord-010092-uftc8inx 1480 5 two two CD cord-010092-uftc8inx 1480 6 SCD SCD NNP cord-010092-uftc8inx 1480 7 patients patient NNS cord-010092-uftc8inx 1480 8 , , , cord-010092-uftc8inx 1480 9 delayed delay VBN cord-010092-uftc8inx 1480 10 haemolytic haemolytic JJ cord-010092-uftc8inx 1480 11 transfusion transfusion NN cord-010092-uftc8inx 1480 12 reaction reaction NN cord-010092-uftc8inx 1480 13 in in IN cord-010092-uftc8inx 1480 14 one one CD cord-010092-uftc8inx 1480 15 thalassaemia thalassaemia NN cord-010092-uftc8inx 1480 16 intermedia intermedia NN cord-010092-uftc8inx 1480 17 patient patient NN cord-010092-uftc8inx 1480 18 . . . cord-010092-uftc8inx 1481 1 Trends trend NNS cord-010092-uftc8inx 1481 2 in in IN cord-010092-uftc8inx 1481 3 2010 2010 CD cord-010092-uftc8inx 1481 4 - - SYM cord-010092-uftc8inx 1481 5 2017 2017 CD cord-010092-uftc8inx 1481 6 show show NN cord-010092-uftc8inx 1481 7 reduced reduce VBN cord-010092-uftc8inx 1481 8 incidence incidence NN cord-010092-uftc8inx 1481 9 of of IN cord-010092-uftc8inx 1481 10 alloimmunisation alloimmunisation NN cord-010092-uftc8inx 1481 11 against against IN cord-010092-uftc8inx 1481 12 RBCs rbc NNS cord-010092-uftc8inx 1481 13 . . . cord-010092-uftc8inx 1482 1 Rates rate NNS cord-010092-uftc8inx 1482 2 of of IN cord-010092-uftc8inx 1482 3 allergic allergic JJ cord-010092-uftc8inx 1482 4 and and CC cord-010092-uftc8inx 1482 5 pyrexial pyrexial JJ cord-010092-uftc8inx 1482 6 ARs ar NNS cord-010092-uftc8inx 1482 7 remained remain VBD cord-010092-uftc8inx 1482 8 stable stable JJ cord-010092-uftc8inx 1482 9 . . . cord-010092-uftc8inx 1483 1 No no DT cord-010092-uftc8inx 1483 2 major major JJ cord-010092-uftc8inx 1483 3 ABO ABO NNP cord-010092-uftc8inx 1483 4 incompatibility incompatibility NN cord-010092-uftc8inx 1483 5 case case NN cord-010092-uftc8inx 1483 6 was be VBD cord-010092-uftc8inx 1483 7 reported report VBN cord-010092-uftc8inx 1483 8 and and CC cord-010092-uftc8inx 1483 9 no no DT cord-010092-uftc8inx 1483 10 fatal fatal JJ cord-010092-uftc8inx 1483 11 transfusion transfusion NN cord-010092-uftc8inx 1483 12 reaction reaction NN cord-010092-uftc8inx 1483 13 of of IN cord-010092-uftc8inx 1483 14 transfusion transfusion NN cord-010092-uftc8inx 1483 15 has have VBZ cord-010092-uftc8inx 1483 16 been be VBN cord-010092-uftc8inx 1483 17 recorded record VBN cord-010092-uftc8inx 1483 18 . . . cord-010092-uftc8inx 1484 1 Summary Summary NNP cord-010092-uftc8inx 1484 2 / / SYM cord-010092-uftc8inx 1484 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 1484 4 : : : cord-010092-uftc8inx 1485 1 Blood blood NN cord-010092-uftc8inx 1485 2 safety safety NN cord-010092-uftc8inx 1485 3 in in IN cord-010092-uftc8inx 1485 4 transfusion transfusion NN cord-010092-uftc8inx 1485 5 has have VBZ cord-010092-uftc8inx 1485 6 significantly significantly RB cord-010092-uftc8inx 1485 7 improved improve VBN cord-010092-uftc8inx 1485 8 in in IN cord-010092-uftc8inx 1485 9 high high JJ cord-010092-uftc8inx 1485 10 and and CC cord-010092-uftc8inx 1485 11 upper upper JJ cord-010092-uftc8inx 1485 12 - - HYPH cord-010092-uftc8inx 1485 13 middle middle JJ cord-010092-uftc8inx 1485 14 income income NN cord-010092-uftc8inx 1485 15 but but CC cord-010092-uftc8inx 1485 16 unfortunately unfortunately RB cord-010092-uftc8inx 1485 17 not not RB cord-010092-uftc8inx 1485 18 in in IN cord-010092-uftc8inx 1485 19 lower low JJR cord-010092-uftc8inx 1485 20 and and CC cord-010092-uftc8inx 1485 21 low low JJ cord-010092-uftc8inx 1485 22 income income NN cord-010092-uftc8inx 1485 23 countries country NNS cord-010092-uftc8inx 1485 24 . . . cord-010092-uftc8inx 1486 1 Blood blood NN cord-010092-uftc8inx 1486 2 shortages shortage NNS cord-010092-uftc8inx 1486 3 and and CC cord-010092-uftc8inx 1486 4 lack lack NN cord-010092-uftc8inx 1486 5 of of IN cord-010092-uftc8inx 1486 6 stringent stringent JJ cord-010092-uftc8inx 1486 7 protective protective JJ cord-010092-uftc8inx 1486 8 measures measure NNS cord-010092-uftc8inx 1486 9 for for IN cord-010092-uftc8inx 1486 10 thalassaemia thalassaemia NN cord-010092-uftc8inx 1486 11 patients patient NNS cord-010092-uftc8inx 1486 12 is be VBZ cord-010092-uftc8inx 1486 13 the the DT cord-010092-uftc8inx 1486 14 reality reality NN cord-010092-uftc8inx 1486 15 for for IN cord-010092-uftc8inx 1486 16 many many JJ cord-010092-uftc8inx 1486 17 developing develop VBG cord-010092-uftc8inx 1486 18 countries country NNS cord-010092-uftc8inx 1486 19 . . . cord-010092-uftc8inx 1487 1 TIF tif NN cord-010092-uftc8inx 1487 2 focuses focus VBZ cord-010092-uftc8inx 1487 3 particular particular JJ cord-010092-uftc8inx 1487 4 attention attention NN cord-010092-uftc8inx 1487 5 on on IN cord-010092-uftc8inx 1487 6 the the DT cord-010092-uftc8inx 1487 7 provision provision NN cord-010092-uftc8inx 1487 8 of of IN cord-010092-uftc8inx 1487 9 support support NN cord-010092-uftc8inx 1487 10 and and CC cord-010092-uftc8inx 1487 11 the the DT cord-010092-uftc8inx 1487 12 promotion promotion NN cord-010092-uftc8inx 1487 13 of of IN cord-010092-uftc8inx 1487 14 initiatives initiative NNS cord-010092-uftc8inx 1487 15 promoting promote VBG cord-010092-uftc8inx 1487 16 the the DT cord-010092-uftc8inx 1487 17 safety safety NN cord-010092-uftc8inx 1487 18 and and CC cord-010092-uftc8inx 1487 19 adequacy adequacy NN cord-010092-uftc8inx 1487 20 of of IN cord-010092-uftc8inx 1487 21 blooda blooda NNP cord-010092-uftc8inx 1487 22 key key JJ cord-010092-uftc8inx 1487 23 component component NN cord-010092-uftc8inx 1487 24 of of IN cord-010092-uftc8inx 1487 25 the the DT cord-010092-uftc8inx 1487 26 lifelong lifelong JJ cord-010092-uftc8inx 1487 27 management management NN cord-010092-uftc8inx 1487 28 of of IN cord-010092-uftc8inx 1487 29 patients patient NNS cord-010092-uftc8inx 1487 30 with with IN cord-010092-uftc8inx 1487 31 transfusion transfusion NN cord-010092-uftc8inx 1487 32 - - HYPH cord-010092-uftc8inx 1487 33 dependent dependent JJ cord-010092-uftc8inx 1487 34 thalassaemia thalassaemia NN cord-010092-uftc8inx 1487 35 . . . cord-010092-uftc8inx 1488 1 Background background NN cord-010092-uftc8inx 1488 2 : : : cord-010092-uftc8inx 1489 1 b b LS cord-010092-uftc8inx 1489 2 Thalassemia thalassemia NN cord-010092-uftc8inx 1489 3 is be VBZ cord-010092-uftc8inx 1489 4 the the DT cord-010092-uftc8inx 1489 5 most most RBS cord-010092-uftc8inx 1489 6 common common JJ cord-010092-uftc8inx 1489 7 group group NN cord-010092-uftc8inx 1489 8 of of IN cord-010092-uftc8inx 1489 9 hereditary hereditary JJ cord-010092-uftc8inx 1489 10 hemoglobinopathy hemoglobinopathy NNP cord-010092-uftc8inx 1489 11 diseases disease NNS cord-010092-uftc8inx 1489 12 . . . cord-010092-uftc8inx 1490 1 Affected affected JJ cord-010092-uftc8inx 1490 2 people people NNS cord-010092-uftc8inx 1490 3 with with IN cord-010092-uftc8inx 1490 4 major major JJ cord-010092-uftc8inx 1490 5 thalassemia thalassemia NN cord-010092-uftc8inx 1490 6 are be VBP cord-010092-uftc8inx 1490 7 dependent dependent JJ cord-010092-uftc8inx 1490 8 on on IN cord-010092-uftc8inx 1490 9 regular regular JJ cord-010092-uftc8inx 1490 10 blood blood NN cord-010092-uftc8inx 1490 11 transfusion transfusion NN cord-010092-uftc8inx 1490 12 which which WDT cord-010092-uftc8inx 1490 13 leads lead VBZ cord-010092-uftc8inx 1490 14 to to IN cord-010092-uftc8inx 1490 15 iron iron NN cord-010092-uftc8inx 1490 16 overload overload NN cord-010092-uftc8inx 1490 17 . . . cord-010092-uftc8inx 1491 1 Hepcidin Hepcidin NNP cord-010092-uftc8inx 1491 2 is be VBZ cord-010092-uftc8inx 1491 3 a a DT cord-010092-uftc8inx 1491 4 peptide peptide NN cord-010092-uftc8inx 1491 5 and and CC cord-010092-uftc8inx 1491 6 an an DT cord-010092-uftc8inx 1491 7 important important JJ cord-010092-uftc8inx 1491 8 regulator regulator NN cord-010092-uftc8inx 1491 9 of of IN cord-010092-uftc8inx 1491 10 iron iron NN cord-010092-uftc8inx 1491 11 homeostasis homeostasis NN cord-010092-uftc8inx 1491 12 . . . cord-010092-uftc8inx 1492 1 Expression expression NN cord-010092-uftc8inx 1492 2 of of IN cord-010092-uftc8inx 1492 3 this this DT cord-010092-uftc8inx 1492 4 hormone hormone NN cord-010092-uftc8inx 1492 5 is be VBZ cord-010092-uftc8inx 1492 6 influenced influence VBN cord-010092-uftc8inx 1492 7 by by IN cord-010092-uftc8inx 1492 8 polymorphisms polymorphism NNS cord-010092-uftc8inx 1492 9 within within IN cord-010092-uftc8inx 1492 10 the the DT cord-010092-uftc8inx 1492 11 hepcidin hepcidin NNP cord-010092-uftc8inx 1492 12 gene gene NN cord-010092-uftc8inx 1492 13 , , , cord-010092-uftc8inx 1492 14 HAMP HAMP NNP cord-010092-uftc8inx 1492 15 . . . cord-010092-uftc8inx 1493 1 Aims aim VBZ cord-010092-uftc8inx 1493 2 : : : cord-010092-uftc8inx 1494 1 This this DT cord-010092-uftc8inx 1494 2 study study NN cord-010092-uftc8inx 1494 3 aimed aim VBD cord-010092-uftc8inx 1494 4 to to TO cord-010092-uftc8inx 1494 5 analyze analyze VB cord-010092-uftc8inx 1494 6 the the DT cord-010092-uftc8inx 1494 7 association association NN cord-010092-uftc8inx 1494 8 of of IN cord-010092-uftc8inx 1494 9 three three CD cord-010092-uftc8inx 1494 10 polymorphisms polymorphism NNS cord-010092-uftc8inx 1494 11 in in IN cord-010092-uftc8inx 1494 12 promoter promoter NN cord-010092-uftc8inx 1494 13 of of IN cord-010092-uftc8inx 1494 14 HAMP HAMP NNP cord-010092-uftc8inx 1494 15 , , , cord-010092-uftc8inx 1494 16 rs10421768 rs10421768 NNP cord-010092-uftc8inx 1494 17 , , , cord-010092-uftc8inx 1494 18 rs117345431 rs117345431 NNP cord-010092-uftc8inx 1494 19 , , , cord-010092-uftc8inx 1494 20 and and CC cord-010092-uftc8inx 1494 21 rs142126068 rs142126068 FW cord-010092-uftc8inx 1494 22 with with IN cord-010092-uftc8inx 1494 23 iron iron NN cord-010092-uftc8inx 1494 24 overload overload NN cord-010092-uftc8inx 1494 25 in in IN cord-010092-uftc8inx 1494 26 major major JJ cord-010092-uftc8inx 1494 27 b b NN cord-010092-uftc8inx 1494 28 thalassemia thalassemia NN cord-010092-uftc8inx 1494 29 patients patient NNS cord-010092-uftc8inx 1494 30 who who WP cord-010092-uftc8inx 1494 31 do do VBP cord-010092-uftc8inx 1494 32 not not RB cord-010092-uftc8inx 1494 33 respond respond VB cord-010092-uftc8inx 1494 34 to to IN cord-010092-uftc8inx 1494 35 iron iron NN cord-010092-uftc8inx 1494 36 chelating chelating NN cord-010092-uftc8inx 1494 37 therapy therapy NN cord-010092-uftc8inx 1494 38 . . . cord-010092-uftc8inx 1495 1 Materials material NNS cord-010092-uftc8inx 1495 2 and and CC cord-010092-uftc8inx 1495 3 Methods method NNS cord-010092-uftc8inx 1495 4 : : : cord-010092-uftc8inx 1495 5 a a DT cord-010092-uftc8inx 1495 6 total total NN cord-010092-uftc8inx 1495 7 of of IN cord-010092-uftc8inx 1495 8 102 102 CD cord-010092-uftc8inx 1495 9 samples sample NNS cord-010092-uftc8inx 1495 10 from from IN cord-010092-uftc8inx 1495 11 major major JJ cord-010092-uftc8inx 1495 12 b b NN cord-010092-uftc8inx 1495 13 thalassemia thalassemia NN cord-010092-uftc8inx 1495 14 patients patient NNS cord-010092-uftc8inx 1495 15 were be VBD cord-010092-uftc8inx 1495 16 collected collect VBN cord-010092-uftc8inx 1495 17 . . . cord-010092-uftc8inx 1496 1 Genomic genomic JJ cord-010092-uftc8inx 1496 2 DNA dna NN cord-010092-uftc8inx 1496 3 was be VBD cord-010092-uftc8inx 1496 4 extracted extract VBN cord-010092-uftc8inx 1496 5 and and CC cord-010092-uftc8inx 1496 6 sequenced sequence VBN cord-010092-uftc8inx 1496 7 for for IN cord-010092-uftc8inx 1496 8 SNPs SNPs NNPS cord-010092-uftc8inx 1496 9 rs10421768 rs10421768 NNP cord-010092-uftc8inx 1496 10 , , , cord-010092-uftc8inx 1496 11 rs117345431 rs117345431 NNP cord-010092-uftc8inx 1496 12 , , , cord-010092-uftc8inx 1496 13 and and CC cord-010092-uftc8inx 1496 14 rs142126068 rs142126068 NNP cord-010092-uftc8inx 1496 15 . . . cord-010092-uftc8inx 1497 1 Statistical statistical JJ cord-010092-uftc8inx 1497 2 analysis analysis NN cord-010092-uftc8inx 1497 3 was be VBD cord-010092-uftc8inx 1497 4 performed perform VBN cord-010092-uftc8inx 1497 5 on on IN cord-010092-uftc8inx 1497 6 IBM*SPSS ibm*spss NN cord-010092-uftc8inx 1497 7 * * NFP cord-010092-uftc8inx 1497 8 STATISTIC statistic NN cord-010092-uftc8inx 1497 9 23 23 CD cord-010092-uftc8inx 1497 10 using use VBG cord-010092-uftc8inx 1497 11 Independent Independent NNP cord-010092-uftc8inx 1497 12 t t NN cord-010092-uftc8inx 1497 13 test test NN cord-010092-uftc8inx 1497 14 and and CC cord-010092-uftc8inx 1497 15 Fisher Fisher NNP cord-010092-uftc8inx 1497 16 test test NN cord-010092-uftc8inx 1497 17 . . . cord-010092-uftc8inx 1498 1 Results result NNS cord-010092-uftc8inx 1498 2 : : : cord-010092-uftc8inx 1499 1 Our -PRON- PRP$ cord-010092-uftc8inx 1499 2 analysis analysis NN cord-010092-uftc8inx 1499 3 revealed reveal VBD cord-010092-uftc8inx 1499 4 statistically statistically RB cord-010092-uftc8inx 1499 5 significantly significantly RB cord-010092-uftc8inx 1499 6 difference difference NN cord-010092-uftc8inx 1499 7 between between IN cord-010092-uftc8inx 1499 8 the the DT cord-010092-uftc8inx 1499 9 level level NN cord-010092-uftc8inx 1499 10 of of IN cord-010092-uftc8inx 1499 11 cardiac cardiac JJ cord-010092-uftc8inx 1499 12 iron iron NN cord-010092-uftc8inx 1499 13 concentration concentration NN cord-010092-uftc8inx 1499 14 and and CC cord-010092-uftc8inx 1499 15 c.-582A c.-582a XX cord-010092-uftc8inx 1499 16 > > XX cord-010092-uftc8inx 1499 17 G g NN cord-010092-uftc8inx 1499 18 variant variant NN cord-010092-uftc8inx 1499 19 ( ( -LRB- cord-010092-uftc8inx 1499 20 P p NN cord-010092-uftc8inx 1499 21 = = SYM cord-010092-uftc8inx 1499 22 0.02 0.02 CD cord-010092-uftc8inx 1499 23 ) ) -RRB- cord-010092-uftc8inx 1499 24 . . . cord-010092-uftc8inx 1500 1 For for IN cord-010092-uftc8inx 1500 2 rs117345431 rs117345431 NNP cord-010092-uftc8inx 1500 3 statistical statistical JJ cord-010092-uftc8inx 1500 4 analysis analysis NN cord-010092-uftc8inx 1500 5 was be VBD cord-010092-uftc8inx 1500 6 on on IN cord-010092-uftc8inx 1500 7 the the DT cord-010092-uftc8inx 1500 8 edge edge NN cord-010092-uftc8inx 1500 9 of of IN cord-010092-uftc8inx 1500 10 significant significant JJ cord-010092-uftc8inx 1500 11 relationship relationship NN cord-010092-uftc8inx 1500 12 between between IN cord-010092-uftc8inx 1500 13 minor minor JJ cord-010092-uftc8inx 1500 14 allele allele NN cord-010092-uftc8inx 1500 15 and and CC cord-010092-uftc8inx 1500 16 serum serum NN cord-010092-uftc8inx 1500 17 ferritin ferritin NN cord-010092-uftc8inx 1500 18 ( ( -LRB- cord-010092-uftc8inx 1500 19 P p NN cord-010092-uftc8inx 1500 20 = = SYM cord-010092-uftc8inx 1500 21 0.058 0.058 CD cord-010092-uftc8inx 1500 22 ) ) -RRB- cord-010092-uftc8inx 1500 23 . . . cord-010092-uftc8inx 1501 1 All all DT cord-010092-uftc8inx 1501 2 samples sample NNS cord-010092-uftc8inx 1501 3 were be VBD cord-010092-uftc8inx 1501 4 homozygous homozygous JJ cord-010092-uftc8inx 1501 5 for for IN cord-010092-uftc8inx 1501 6 allele allele NN cord-010092-uftc8inx 1501 7 T T NNP cord-010092-uftc8inx 1501 8 of of IN cord-010092-uftc8inx 1501 9 rs142126068 rs142126068 NNP cord-010092-uftc8inx 1501 10 . . . cord-010092-uftc8inx 1502 1 Summary Summary NNP cord-010092-uftc8inx 1502 2 / / SYM cord-010092-uftc8inx 1502 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 1502 4 : : : cord-010092-uftc8inx 1502 5 different different JJ cord-010092-uftc8inx 1502 6 factors factor NNS cord-010092-uftc8inx 1502 7 affect affect VBP cord-010092-uftc8inx 1502 8 iron iron NN cord-010092-uftc8inx 1502 9 overload overload NN cord-010092-uftc8inx 1502 10 in in IN cord-010092-uftc8inx 1502 11 thalassemia thalassemia NN cord-010092-uftc8inx 1502 12 . . . cord-010092-uftc8inx 1503 1 Our -PRON- PRP$ cord-010092-uftc8inx 1503 2 findings finding NNS cord-010092-uftc8inx 1503 3 and and CC cord-010092-uftc8inx 1503 4 others other NNS cord-010092-uftc8inx 1503 5 emphasize emphasize VBP cord-010092-uftc8inx 1503 6 the the DT cord-010092-uftc8inx 1503 7 role role NN cord-010092-uftc8inx 1503 8 of of IN cord-010092-uftc8inx 1503 9 hepcidin hepcidin NNP cord-010092-uftc8inx 1503 10 polymorphism polymorphism NN cord-010092-uftc8inx 1503 11 as as IN cord-010092-uftc8inx 1503 12 a a DT cord-010092-uftc8inx 1503 13 key key JJ cord-010092-uftc8inx 1503 14 component component NN cord-010092-uftc8inx 1503 15 in in IN cord-010092-uftc8inx 1503 16 iron iron NN cord-010092-uftc8inx 1503 17 homeostasis homeostasis NN cord-010092-uftc8inx 1503 18 . . . cord-010092-uftc8inx 1504 1 Ten ten CD cord-010092-uftc8inx 1504 2 to to TO cord-010092-uftc8inx 1504 3 twenty twenty CD cord-010092-uftc8inx 1504 4 years year NNS cord-010092-uftc8inx 1504 5 ago ago RB cord-010092-uftc8inx 1504 6 , , , cord-010092-uftc8inx 1504 7 countries country NNS cord-010092-uftc8inx 1504 8 in in IN cord-010092-uftc8inx 1504 9 South South NNP cord-010092-uftc8inx 1504 10 Eastern Eastern NNP cord-010092-uftc8inx 1504 11 Africa Africa NNP cord-010092-uftc8inx 1504 12 faced face VBD cord-010092-uftc8inx 1504 13 the the DT cord-010092-uftc8inx 1504 14 peak peak NN cord-010092-uftc8inx 1504 15 of of IN cord-010092-uftc8inx 1504 16 the the DT cord-010092-uftc8inx 1504 17 devasting devasting JJ cord-010092-uftc8inx 1504 18 HIV HIV NNP cord-010092-uftc8inx 1504 19 / / SYM cord-010092-uftc8inx 1504 20 AIDS AIDS NNP cord-010092-uftc8inx 1504 21 epidemic epidemic NN cord-010092-uftc8inx 1504 22 leading lead VBG cord-010092-uftc8inx 1504 23 to to IN cord-010092-uftc8inx 1504 24 an an DT cord-010092-uftc8inx 1504 25 up up NN cord-010092-uftc8inx 1504 26 to to TO cord-010092-uftc8inx 1504 27 20 20 CD cord-010092-uftc8inx 1504 28 years year NNS cord-010092-uftc8inx 1504 29 drop drop VBP cord-010092-uftc8inx 1504 30 in in IN cord-010092-uftc8inx 1504 31 general general JJ cord-010092-uftc8inx 1504 32 life life NN cord-010092-uftc8inx 1504 33 expectancy expectancy NN cord-010092-uftc8inx 1504 34 . . . cord-010092-uftc8inx 1505 1 With with IN cord-010092-uftc8inx 1505 2 the the DT cord-010092-uftc8inx 1505 3 burden burden NN cord-010092-uftc8inx 1505 4 of of IN cord-010092-uftc8inx 1505 5 HIV HIV NNP cord-010092-uftc8inx 1505 6 / / SYM cord-010092-uftc8inx 1505 7 AIDS AIDS NNP cord-010092-uftc8inx 1505 8 falling fall VBG cord-010092-uftc8inx 1505 9 mainly mainly RB cord-010092-uftc8inx 1505 10 on on IN cord-010092-uftc8inx 1505 11 the the DT cord-010092-uftc8inx 1505 12 economically economically RB cord-010092-uftc8inx 1505 13 active active JJ cord-010092-uftc8inx 1505 14 population population NN cord-010092-uftc8inx 1505 15 of of IN cord-010092-uftc8inx 1505 16 young young JJ cord-010092-uftc8inx 1505 17 and and CC cord-010092-uftc8inx 1505 18 medium medium NN cord-010092-uftc8inx 1505 19 - - HYPH cord-010092-uftc8inx 1505 20 aged aged JJ cord-010092-uftc8inx 1505 21 adults adult NNS cord-010092-uftc8inx 1505 22 , , , cord-010092-uftc8inx 1505 23 the the DT cord-010092-uftc8inx 1505 24 epidemic epidemic NN cord-010092-uftc8inx 1505 25 endangered endanger VBN cord-010092-uftc8inx 1505 26 social social JJ cord-010092-uftc8inx 1505 27 and and CC cord-010092-uftc8inx 1505 28 economic economic JJ cord-010092-uftc8inx 1505 29 stability stability NN cord-010092-uftc8inx 1505 30 in in IN cord-010092-uftc8inx 1505 31 nations nation NNS cord-010092-uftc8inx 1505 32 most most RBS cord-010092-uftc8inx 1505 33 heavily heavily RB cord-010092-uftc8inx 1505 34 affected affect VBN cord-010092-uftc8inx 1505 35 . . . cord-010092-uftc8inx 1506 1 Today today NN cord-010092-uftc8inx 1506 2 , , , cord-010092-uftc8inx 1506 3 despite despite IN cord-010092-uftc8inx 1506 4 AIDS AIDS NNP cord-010092-uftc8inx 1506 5 still still RB cord-010092-uftc8inx 1506 6 being be VBG cord-010092-uftc8inx 1506 7 a a DT cord-010092-uftc8inx 1506 8 major major JJ cord-010092-uftc8inx 1506 9 cause cause NN cord-010092-uftc8inx 1506 10 of of IN cord-010092-uftc8inx 1506 11 death death NN cord-010092-uftc8inx 1506 12 in in IN cord-010092-uftc8inx 1506 13 South South NNP cord-010092-uftc8inx 1506 14 Eastern Eastern NNP cord-010092-uftc8inx 1506 15 Africa Africa NNP cord-010092-uftc8inx 1506 16 , , , cord-010092-uftc8inx 1506 17 the the DT cord-010092-uftc8inx 1506 18 epidemic epidemic NN cord-010092-uftc8inx 1506 19 has have VBZ cord-010092-uftc8inx 1506 20 become become VBN cord-010092-uftc8inx 1506 21 an an DT cord-010092-uftc8inx 1506 22 example example NN cord-010092-uftc8inx 1506 23 of of IN cord-010092-uftc8inx 1506 24 public public JJ cord-010092-uftc8inx 1506 25 health health NN cord-010092-uftc8inx 1506 26 gains gain NNS cord-010092-uftc8inx 1506 27 that that WDT cord-010092-uftc8inx 1506 28 can can MD cord-010092-uftc8inx 1506 29 be be VB cord-010092-uftc8inx 1506 30 achieved achieve VBN cord-010092-uftc8inx 1506 31 through through IN cord-010092-uftc8inx 1506 32 programmatic programmatic JJ cord-010092-uftc8inx 1506 33 , , , cord-010092-uftc8inx 1506 34 evidencebased evidencebased JJ cord-010092-uftc8inx 1506 35 approaches approach NNS cord-010092-uftc8inx 1506 36 that that WDT cord-010092-uftc8inx 1506 37 are be VBP cord-010092-uftc8inx 1506 38 endorsed endorse VBN cord-010092-uftc8inx 1506 39 by by IN cord-010092-uftc8inx 1506 40 globally globally RB cord-010092-uftc8inx 1506 41 aligned align VBN cord-010092-uftc8inx 1506 42 policy policy NN cord-010092-uftc8inx 1506 43 and and CC cord-010092-uftc8inx 1506 44 funding funding NN cord-010092-uftc8inx 1506 45 strategies strategy NNS cord-010092-uftc8inx 1506 46 . . . cord-010092-uftc8inx 1507 1 Based base VBN cord-010092-uftc8inx 1507 2 on on IN cord-010092-uftc8inx 1507 3 his -PRON- PRP$ cord-010092-uftc8inx 1507 4 work work NN cord-010092-uftc8inx 1507 5 from from IN cord-010092-uftc8inx 1507 6 Lesotho Lesotho NNP cord-010092-uftc8inx 1507 7 , , , cord-010092-uftc8inx 1507 8 where where WRB cord-010092-uftc8inx 1507 9 one one CD cord-010092-uftc8inx 1507 10 out out IN cord-010092-uftc8inx 1507 11 of of IN cord-010092-uftc8inx 1507 12 four four CD cord-010092-uftc8inx 1507 13 among among IN cord-010092-uftc8inx 1507 14 adults adult NNS cord-010092-uftc8inx 1507 15 is be VBZ cord-010092-uftc8inx 1507 16 infected infect VBN cord-010092-uftc8inx 1507 17 by by IN cord-010092-uftc8inx 1507 18 HIV HIV NNP cord-010092-uftc8inx 1507 19 , , , cord-010092-uftc8inx 1507 20 Niklaus Niklaus NNP cord-010092-uftc8inx 1507 21 Labhardt Labhardt NNP cord-010092-uftc8inx 1507 22 will will MD cord-010092-uftc8inx 1507 23 take take VB cord-010092-uftc8inx 1507 24 the the DT cord-010092-uftc8inx 1507 25 auditors auditor NNS cord-010092-uftc8inx 1507 26 through through IN cord-010092-uftc8inx 1507 27 the the DT cord-010092-uftc8inx 1507 28 history history NN cord-010092-uftc8inx 1507 29 of of IN cord-010092-uftc8inx 1507 30 HIV HIV NNP cord-010092-uftc8inx 1507 31 programs program NNS cord-010092-uftc8inx 1507 32 in in IN cord-010092-uftc8inx 1507 33 South South NNP cord-010092-uftc8inx 1507 34 Eastern Eastern NNP cord-010092-uftc8inx 1507 35 Africa Africa NNP cord-010092-uftc8inx 1507 36 and and CC cord-010092-uftc8inx 1507 37 show show VB cord-010092-uftc8inx 1507 38 how how WRB cord-010092-uftc8inx 1507 39 innovative innovative JJ cord-010092-uftc8inx 1507 40 , , , cord-010092-uftc8inx 1507 41 pragmatic pragmatic JJ cord-010092-uftc8inx 1507 42 and and CC cord-010092-uftc8inx 1507 43 evidence evidence NN cord-010092-uftc8inx 1507 44 based base VBN cord-010092-uftc8inx 1507 45 implementation implementation NN cord-010092-uftc8inx 1507 46 brought bring VBD cord-010092-uftc8inx 1507 47 the the DT cord-010092-uftc8inx 1507 48 region region NN cord-010092-uftc8inx 1507 49 to to IN cord-010092-uftc8inx 1507 50 a a DT cord-010092-uftc8inx 1507 51 stage stage NN cord-010092-uftc8inx 1507 52 where where WRB cord-010092-uftc8inx 1507 53 the the DT cord-010092-uftc8inx 1507 54 goal goal NN cord-010092-uftc8inx 1507 55 to to TO cord-010092-uftc8inx 1507 56 end end VB cord-010092-uftc8inx 1507 57 the the DT cord-010092-uftc8inx 1507 58 AIDS AIDS NNP cord-010092-uftc8inx 1507 59 epidemic epidemic NN cord-010092-uftc8inx 1507 60 by by IN cord-010092-uftc8inx 1507 61 2030 2030 CD cord-010092-uftc8inx 1507 62 might may MD cord-010092-uftc8inx 1507 63 be be VB cord-010092-uftc8inx 1507 64 in in IN cord-010092-uftc8inx 1507 65 reach reach NN cord-010092-uftc8inx 1507 66 . . . cord-010092-uftc8inx 1508 1 Background background NN cord-010092-uftc8inx 1508 2 : : : cord-010092-uftc8inx 1509 1 In in IN cord-010092-uftc8inx 1509 2 France France NNP cord-010092-uftc8inx 1509 3 , , , cord-010092-uftc8inx 1509 4 the the DT cord-010092-uftc8inx 1509 5 deferral deferral NN cord-010092-uftc8inx 1509 6 for for IN cord-010092-uftc8inx 1509 7 men man NNS cord-010092-uftc8inx 1509 8 who who WP cord-010092-uftc8inx 1509 9 have have VBP cord-010092-uftc8inx 1509 10 sex sex NN cord-010092-uftc8inx 1509 11 with with IN cord-010092-uftc8inx 1509 12 men man NNS cord-010092-uftc8inx 1509 13 ( ( -LRB- cord-010092-uftc8inx 1509 14 MSM MSM NNP cord-010092-uftc8inx 1509 15 ) ) -RRB- cord-010092-uftc8inx 1509 16 was be VBD cord-010092-uftc8inx 1509 17 reduced reduce VBN cord-010092-uftc8inx 1509 18 from from IN cord-010092-uftc8inx 1509 19 permanent permanent JJ cord-010092-uftc8inx 1509 20 to to TO cord-010092-uftc8inx 1509 21 12 12 CD cord-010092-uftc8inx 1509 22 months month NNS cord-010092-uftc8inx 1509 23 in in IN cord-010092-uftc8inx 1509 24 July July NNP cord-010092-uftc8inx 1509 25 2016 2016 CD cord-010092-uftc8inx 1509 26 . . . cord-010092-uftc8inx 1510 1 Since since IN cord-010092-uftc8inx 1510 2 this this DT cord-010092-uftc8inx 1510 3 change change NN cord-010092-uftc8inx 1510 4 has have VBZ cord-010092-uftc8inx 1510 5 not not RB cord-010092-uftc8inx 1510 6 impacted impact VBN cord-010092-uftc8inx 1510 7 the the DT cord-010092-uftc8inx 1510 8 residual residual JJ cord-010092-uftc8inx 1510 9 risk risk NN cord-010092-uftc8inx 1510 10 ( ( -LRB- cord-010092-uftc8inx 1510 11 RR rr NN cord-010092-uftc8inx 1510 12 ) ) -RRB- cord-010092-uftc8inx 1510 13 of of IN cord-010092-uftc8inx 1510 14 undetected undetected JJ cord-010092-uftc8inx 1510 15 HIV HIV NNP cord-010092-uftc8inx 1510 16 among among IN cord-010092-uftc8inx 1510 17 blood blood NN cord-010092-uftc8inx 1510 18 donations donation NNS cord-010092-uftc8inx 1510 19 , , , cord-010092-uftc8inx 1510 20 the the DT cord-010092-uftc8inx 1510 21 Ministry Ministry NNP cord-010092-uftc8inx 1510 22 of of IN cord-010092-uftc8inx 1510 23 Health Health NNP cord-010092-uftc8inx 1510 24 is be VBZ cord-010092-uftc8inx 1510 25 considering consider VBG cord-010092-uftc8inx 1510 26 a a DT cord-010092-uftc8inx 1510 27 greater great JJR cord-010092-uftc8inx 1510 28 access access NN cord-010092-uftc8inx 1510 29 of of IN cord-010092-uftc8inx 1510 30 blood blood NN cord-010092-uftc8inx 1510 31 donation donation NN cord-010092-uftc8inx 1510 32 to to IN cord-010092-uftc8inx 1510 33 MSM MSM NNP cord-010092-uftc8inx 1510 34 . . . cord-010092-uftc8inx 1511 1 Two two CD cord-010092-uftc8inx 1511 2 scenarios scenario NNS cord-010092-uftc8inx 1511 3 have have VBP cord-010092-uftc8inx 1511 4 been be VBN cord-010092-uftc8inx 1511 5 studied study VBN cord-010092-uftc8inx 1511 6 : : : cord-010092-uftc8inx 1511 7 S1 s1 NN cord-010092-uftc8inx 1511 8 . . . cord-010092-uftc8inx 1512 1 deferral deferral NN cord-010092-uftc8inx 1512 2 of of IN cord-010092-uftc8inx 1512 3 MSM MSM NNP cord-010092-uftc8inx 1512 4 during during IN cord-010092-uftc8inx 1512 5 the the DT cord-010092-uftc8inx 1512 6 4 4 CD cord-010092-uftc8inx 1512 7 months month NNS cord-010092-uftc8inx 1512 8 preceding precede VBG cord-010092-uftc8inx 1512 9 the the DT cord-010092-uftc8inx 1512 10 donation donation NN cord-010092-uftc8inx 1512 11 ; ; : cord-010092-uftc8inx 1512 12 S2 S2 NNP cord-010092-uftc8inx 1512 13 . . . cord-010092-uftc8inx 1513 1 deferral deferral NN cord-010092-uftc8inx 1513 2 of of IN cord-010092-uftc8inx 1513 3 MSM MSM NNP cord-010092-uftc8inx 1513 4 who who WP cord-010092-uftc8inx 1513 5 have have VBP cord-010092-uftc8inx 1513 6 had have VBN cord-010092-uftc8inx 1513 7 more more JJR cord-010092-uftc8inx 1513 8 than than IN cord-010092-uftc8inx 1513 9 one one CD cord-010092-uftc8inx 1513 10 sexual sexual JJ cord-010092-uftc8inx 1513 11 partner partner NN cord-010092-uftc8inx 1513 12 in in IN cord-010092-uftc8inx 1513 13 the the DT cord-010092-uftc8inx 1513 14 4 4 CD cord-010092-uftc8inx 1513 15 months month NNS cord-010092-uftc8inx 1513 16 preceding precede VBG cord-010092-uftc8inx 1513 17 the the DT cord-010092-uftc8inx 1513 18 donation donation NN cord-010092-uftc8inx 1513 19 , , , cord-010092-uftc8inx 1513 20 similarly similarly RB cord-010092-uftc8inx 1513 21 to to IN cord-010092-uftc8inx 1513 22 all all DT cord-010092-uftc8inx 1513 23 other other JJ cord-010092-uftc8inx 1513 24 blood blood NN cord-010092-uftc8inx 1513 25 donors donor NNS cord-010092-uftc8inx 1513 26 in in IN cord-010092-uftc8inx 1513 27 France France NNP cord-010092-uftc8inx 1513 28 . . . cord-010092-uftc8inx 1514 1 Aims aim VBZ cord-010092-uftc8inx 1514 2 : : : cord-010092-uftc8inx 1515 1 To to TO cord-010092-uftc8inx 1515 2 assess assess VB cord-010092-uftc8inx 1515 3 the the DT cord-010092-uftc8inx 1515 4 impact impact NN cord-010092-uftc8inx 1515 5 of of IN cord-010092-uftc8inx 1515 6 these these DT cord-010092-uftc8inx 1515 7 two two CD cord-010092-uftc8inx 1515 8 scenarios scenario NNS cord-010092-uftc8inx 1515 9 on on IN cord-010092-uftc8inx 1515 10 the the DT cord-010092-uftc8inx 1515 11 HIV HIV NNP cord-010092-uftc8inx 1515 12 RR RR NNP cord-010092-uftc8inx 1515 13 estimated estimate VBD cord-010092-uftc8inx 1515 14 over over IN cord-010092-uftc8inx 1515 15 the the DT cord-010092-uftc8inx 1515 16 period period NN cord-010092-uftc8inx 1515 17 July July NNP cord-010092-uftc8inx 1515 18 2016-December 2016-december CD cord-010092-uftc8inx 1515 19 2017 2017 CD cord-010092-uftc8inx 1515 20 which which WDT cord-010092-uftc8inx 1515 21 is be VBZ cord-010092-uftc8inx 1515 22 the the DT cord-010092-uftc8inx 1515 23 baseline baseline JJ cord-010092-uftc8inx 1515 24 RR rr NN cord-010092-uftc8inx 1515 25 with with IN cord-010092-uftc8inx 1515 26 the the DT cord-010092-uftc8inx 1515 27 current current JJ cord-010092-uftc8inx 1515 28 12month 12month JJ cord-010092-uftc8inx 1515 29 deferral deferral NN cord-010092-uftc8inx 1515 30 for for IN cord-010092-uftc8inx 1515 31 MSM MSM NNP cord-010092-uftc8inx 1515 32 . . . cord-010092-uftc8inx 1516 1 Methods method NNS cord-010092-uftc8inx 1516 2 : : : cord-010092-uftc8inx 1517 1 Baseline baseline JJ cord-010092-uftc8inx 1517 2 HIV HIV NNP cord-010092-uftc8inx 1517 3 RR RR NNP cord-010092-uftc8inx 1517 4 was be VBD cord-010092-uftc8inx 1517 5 calculated calculate VBN cord-010092-uftc8inx 1517 6 with with IN cord-010092-uftc8inx 1517 7 the the DT cord-010092-uftc8inx 1517 8 classical classical JJ cord-010092-uftc8inx 1517 9 Incidence Incidence NNP cord-010092-uftc8inx 1517 10 - - HYPH cord-010092-uftc8inx 1517 11 Window Window NNP cord-010092-uftc8inx 1517 12 - - HYPH cord-010092-uftc8inx 1517 13 Period Period NNP cord-010092-uftc8inx 1517 14 method method NN cord-010092-uftc8inx 1517 15 , , , cord-010092-uftc8inx 1517 16 where where WRB cord-010092-uftc8inx 1517 17 HIV HIV NNP cord-010092-uftc8inx 1517 18 incidence incidence NN cord-010092-uftc8inx 1517 19 was be VBD cord-010092-uftc8inx 1517 20 derived derive VBN cord-010092-uftc8inx 1517 21 from from IN cord-010092-uftc8inx 1517 22 a a DT cord-010092-uftc8inx 1517 23 detuned detuned JJ cord-010092-uftc8inx 1517 24 assay assay NN cord-010092-uftc8inx 1517 25 ( ( -LRB- cord-010092-uftc8inx 1517 26 EIA EIA NNP cord-010092-uftc8inx 1517 27 - - HYPH cord-010092-uftc8inx 1517 28 RI RI NNP cord-010092-uftc8inx 1517 29 ) ) -RRB- cord-010092-uftc8inx 1517 30 detecting detect VBG cord-010092-uftc8inx 1517 31 recent recent JJ cord-010092-uftc8inx 1517 32 infections infection NNS cord-010092-uftc8inx 1517 33 ( ( -LRB- cord-010092-uftc8inx 1517 34 ≤180 ≤180 JJS cord-010092-uftc8inx 1517 35 days day NNS cord-010092-uftc8inx 1517 36 ) ) -RRB- cord-010092-uftc8inx 1517 37 since since IN cord-010092-uftc8inx 1517 38 all all DT cord-010092-uftc8inx 1517 39 HIV-1 HIV-1 NNP cord-010092-uftc8inx 1517 40 antibodies antibody NNS cord-010092-uftc8inx 1517 41 positive positive JJ cord-010092-uftc8inx 1517 42 blood blood NN cord-010092-uftc8inx 1517 43 donations donation NNS cord-010092-uftc8inx 1517 44 are be VBP cord-010092-uftc8inx 1517 45 tested test VBN cord-010092-uftc8inx 1517 46 with with IN cord-010092-uftc8inx 1517 47 this this DT cord-010092-uftc8inx 1517 48 test test NN cord-010092-uftc8inx 1517 49 . . . cord-010092-uftc8inx 1518 1 The the DT cord-010092-uftc8inx 1518 2 assessment assessment NN cord-010092-uftc8inx 1518 3 of of IN cord-010092-uftc8inx 1518 4 the the DT cord-010092-uftc8inx 1518 5 impact impact NN cord-010092-uftc8inx 1518 6 of of IN cord-010092-uftc8inx 1518 7 both both DT cord-010092-uftc8inx 1518 8 scenarios scenario NNS cord-010092-uftc8inx 1518 9 on on IN cord-010092-uftc8inx 1518 10 the the DT cord-010092-uftc8inx 1518 11 baseline baseline JJ cord-010092-uftc8inx 1518 12 HIV HIV NNP cord-010092-uftc8inx 1518 13 RR RR NNP cord-010092-uftc8inx 1518 14 was be VBD cord-010092-uftc8inx 1518 15 based base VBN cord-010092-uftc8inx 1518 16 on on IN cord-010092-uftc8inx 1518 17 ( ( -LRB- cord-010092-uftc8inx 1518 18 i i NN cord-010092-uftc8inx 1518 19 ) ) -RRB- cord-010092-uftc8inx 1518 20 data datum NNS cord-010092-uftc8inx 1518 21 obtained obtain VBN cord-010092-uftc8inx 1518 22 from from IN cord-010092-uftc8inx 1518 23 surveys survey NNS cord-010092-uftc8inx 1518 24 among among IN cord-010092-uftc8inx 1518 25 MSM MSM NNP cord-010092-uftc8inx 1518 26 in in IN cord-010092-uftc8inx 1518 27 the the DT cord-010092-uftc8inx 1518 28 general general JJ cord-010092-uftc8inx 1518 29 population population NN cord-010092-uftc8inx 1518 30 and and CC cord-010092-uftc8inx 1518 31 in in IN cord-010092-uftc8inx 1518 32 blood blood NN cord-010092-uftc8inx 1518 33 donors donor NNS cord-010092-uftc8inx 1518 34 ( ( -LRB- cord-010092-uftc8inx 1518 35 compliance compliance NN cord-010092-uftc8inx 1518 36 survey survey NN cord-010092-uftc8inx 1518 37 ) ) -RRB- cord-010092-uftc8inx 1518 38 , , , cord-010092-uftc8inx 1518 39 to to TO cord-010092-uftc8inx 1518 40 estimate estimate VB cord-010092-uftc8inx 1518 41 the the DT cord-010092-uftc8inx 1518 42 number number NN cord-010092-uftc8inx 1518 43 of of IN cord-010092-uftc8inx 1518 44 additional additional JJ cord-010092-uftc8inx 1518 45 MSM MSM NNP cord-010092-uftc8inx 1518 46 who who WP cord-010092-uftc8inx 1518 47 would would MD cord-010092-uftc8inx 1518 48 give give VB cord-010092-uftc8inx 1518 49 blood blood NN cord-010092-uftc8inx 1518 50 in in IN cord-010092-uftc8inx 1518 51 each each DT cord-010092-uftc8inx 1518 52 scenario scenario NN cord-010092-uftc8inx 1518 53 , , , cord-010092-uftc8inx 1518 54 and and CC cord-010092-uftc8inx 1518 55 on on IN cord-010092-uftc8inx 1518 56 ( ( -LRB- cord-010092-uftc8inx 1518 57 ii ii NN cord-010092-uftc8inx 1518 58 ) ) -RRB- cord-010092-uftc8inx 1518 59 HIV HIV NNP cord-010092-uftc8inx 1518 60 incidence incidence NN cord-010092-uftc8inx 1518 61 estimate estimate NN cord-010092-uftc8inx 1518 62 among among IN cord-010092-uftc8inx 1518 63 these these DT cord-010092-uftc8inx 1518 64 additional additional JJ cord-010092-uftc8inx 1518 65 donors donor NNS cord-010092-uftc8inx 1518 66 . . . cord-010092-uftc8inx 1519 1 This this DT cord-010092-uftc8inx 1519 2 incidence incidence NN cord-010092-uftc8inx 1519 3 was be VBD cord-010092-uftc8inx 1519 4 estimated estimate VBN cord-010092-uftc8inx 1519 5 : : : cord-010092-uftc8inx 1519 6 for for IN cord-010092-uftc8inx 1519 7 S1 s1 NN cord-010092-uftc8inx 1519 8 , , , cord-010092-uftc8inx 1519 9 from from IN cord-010092-uftc8inx 1519 10 MSM MSM NNP cord-010092-uftc8inx 1519 11 blood blood NN cord-010092-uftc8inx 1519 12 donors donor NNS cord-010092-uftc8inx 1519 13 with with IN cord-010092-uftc8inx 1519 14 the the DT cord-010092-uftc8inx 1519 15 current current JJ cord-010092-uftc8inx 1519 16 deferral deferral NN cord-010092-uftc8inx 1519 17 policy policy NN cord-010092-uftc8inx 1519 18 ( ( -LRB- cord-010092-uftc8inx 1519 19 12 12 CD cord-010092-uftc8inx 1519 20 months month NNS cord-010092-uftc8inx 1519 21 ) ) -RRB- cord-010092-uftc8inx 1519 22 and and CC cord-010092-uftc8inx 1519 23 for for IN cord-010092-uftc8inx 1519 24 S2 S2 NNP cord-010092-uftc8inx 1519 25 , , , cord-010092-uftc8inx 1519 26 from from IN cord-010092-uftc8inx 1519 27 monogamous monogamous JJ cord-010092-uftc8inx 1519 28 MSM MSM NNP cord-010092-uftc8inx 1519 29 of of IN cord-010092-uftc8inx 1519 30 the the DT cord-010092-uftc8inx 1519 31 general general JJ cord-010092-uftc8inx 1519 32 population population NN cord-010092-uftc8inx 1519 33 . . . cord-010092-uftc8inx 1520 1 Results result NNS cord-010092-uftc8inx 1520 2 : : : cord-010092-uftc8inx 1521 1 From from IN cord-010092-uftc8inx 1521 2 July July NNP cord-010092-uftc8inx 1521 3 2016 2016 CD cord-010092-uftc8inx 1521 4 to to IN cord-010092-uftc8inx 1521 5 December December NNP cord-010092-uftc8inx 1521 6 2017 2017 CD cord-010092-uftc8inx 1521 7 , , , cord-010092-uftc8inx 1521 8 8/28 8/28 CD cord-010092-uftc8inx 1521 9 ( ( -LRB- cord-010092-uftc8inx 1521 10 29 29 CD cord-010092-uftc8inx 1521 11 % % NN cord-010092-uftc8inx 1521 12 ) ) -RRB- cord-010092-uftc8inx 1522 1 HIV-1 HIV-1 NNP cord-010092-uftc8inx 1522 2 positive positive JJ cord-010092-uftc8inx 1522 3 blood blood NN cord-010092-uftc8inx 1522 4 donors donor NNS cord-010092-uftc8inx 1522 5 tested test VBN cord-010092-uftc8inx 1522 6 with with IN cord-010092-uftc8inx 1522 7 the the DT cord-010092-uftc8inx 1522 8 EIA EIA NNP cord-010092-uftc8inx 1522 9 - - HYPH cord-010092-uftc8inx 1522 10 RI RI NNP cord-010092-uftc8inx 1522 11 were be VBD cord-010092-uftc8inx 1522 12 identified identify VBN cord-010092-uftc8inx 1522 13 as as IN cord-010092-uftc8inx 1522 14 recently recently RB cord-010092-uftc8inx 1522 15 infected infect VBN cord-010092-uftc8inx 1522 16 , , , cord-010092-uftc8inx 1522 17 allowing allow VBG cord-010092-uftc8inx 1522 18 to to TO cord-010092-uftc8inx 1522 19 estimate estimate VB cord-010092-uftc8inx 1522 20 the the DT cord-010092-uftc8inx 1522 21 baseline baseline JJ cord-010092-uftc8inx 1522 22 HIV HIV NNP cord-010092-uftc8inx 1522 23 RR RR NNP cord-010092-uftc8inx 1522 24 at at IN cord-010092-uftc8inx 1522 25 0.16 0.16 CD cord-010092-uftc8inx 1522 26 in in IN cord-010092-uftc8inx 1522 27 1 1 CD cord-010092-uftc8inx 1522 28 million million CD cord-010092-uftc8inx 1522 29 donations donation NNS cord-010092-uftc8inx 1522 30 [ [ -LRB- cord-010092-uftc8inx 1522 31 95 95 CD cord-010092-uftc8inx 1522 32 % % NN cord-010092-uftc8inx 1522 33 CI ci NN cord-010092-uftc8inx 1522 34 : : : cord-010092-uftc8inx 1522 35 0.04 0.04 CD cord-010092-uftc8inx 1522 36 - - SYM cord-010092-uftc8inx 1522 37 0.34 0.34 CD cord-010092-uftc8inx 1522 38 ] ] -RRB- cord-010092-uftc8inx 1522 39 , , , cord-010092-uftc8inx 1522 40 or or CC cord-010092-uftc8inx 1522 41 1 1 CD cord-010092-uftc8inx 1522 42 in in IN cord-010092-uftc8inx 1522 43 6,380,000 6,380,000 CD cord-010092-uftc8inx 1522 44 donations donation NNS cord-010092-uftc8inx 1522 45 . . . cord-010092-uftc8inx 1523 1 For for IN cord-010092-uftc8inx 1523 2 S1 s1 NN cord-010092-uftc8inx 1523 3 , , , cord-010092-uftc8inx 1523 4 the the DT cord-010092-uftc8inx 1523 5 number number NN cord-010092-uftc8inx 1523 6 of of IN cord-010092-uftc8inx 1523 7 additional additional JJ cord-010092-uftc8inx 1523 8 MSM MSM NNP cord-010092-uftc8inx 1523 9 donors donor NNS cord-010092-uftc8inx 1523 10 was be VBD cord-010092-uftc8inx 1523 11 estimated estimate VBN cord-010092-uftc8inx 1523 12 at at IN cord-010092-uftc8inx 1523 13 733 733 CD cord-010092-uftc8inx 1523 14 and and CC cord-010092-uftc8inx 1523 15 the the DT cord-010092-uftc8inx 1523 16 number number NN cord-010092-uftc8inx 1523 17 of of IN cord-010092-uftc8inx 1523 18 additional additional JJ cord-010092-uftc8inx 1523 19 HIV HIV NNP cord-010092-uftc8inx 1523 20 positive positive JJ cord-010092-uftc8inx 1523 21 donations donation NNS cord-010092-uftc8inx 1523 22 at at IN cord-010092-uftc8inx 1523 23 0.09 0.09 CD cord-010092-uftc8inx 1523 24 , , , cord-010092-uftc8inx 1523 25 resulting result VBG cord-010092-uftc8inx 1523 26 in in IN cord-010092-uftc8inx 1523 27 an an DT cord-010092-uftc8inx 1523 28 HIV HIV NNP cord-010092-uftc8inx 1523 29 RR RR NNP cord-010092-uftc8inx 1523 30 of of IN cord-010092-uftc8inx 1523 31 0.16 0.16 CD cord-010092-uftc8inx 1523 32 in in IN cord-010092-uftc8inx 1523 33 1 1 CD cord-010092-uftc8inx 1523 34 million million CD cord-010092-uftc8inx 1523 35 donations donation NNS cord-010092-uftc8inx 1523 36 [ [ -LRB- cord-010092-uftc8inx 1523 37 95 95 CD cord-010092-uftc8inx 1523 38 % % NN cord-010092-uftc8inx 1523 39 CI ci NN cord-010092-uftc8inx 1523 40 : : : cord-010092-uftc8inx 1523 41 0.04 0.04 CD cord-010092-uftc8inx 1523 42 - - SYM cord-010092-uftc8inx 1523 43 0.35 0.35 CD cord-010092-uftc8inx 1523 44 ] ] -RRB- cord-010092-uftc8inx 1523 45 or or CC cord-010092-uftc8inx 1523 46 1 1 CD cord-010092-uftc8inx 1523 47 in in IN cord-010092-uftc8inx 1523 48 6,300,000 6,300,000 CD cord-010092-uftc8inx 1523 49 donations donation NNS cord-010092-uftc8inx 1523 50 . . . cord-010092-uftc8inx 1524 1 For for IN cord-010092-uftc8inx 1524 2 S2 S2 NNP cord-010092-uftc8inx 1524 3 , , , cord-010092-uftc8inx 1524 4 the the DT cord-010092-uftc8inx 1524 5 number number NN cord-010092-uftc8inx 1524 6 of of IN cord-010092-uftc8inx 1524 7 additional additional JJ cord-010092-uftc8inx 1524 8 MSM MSM NNP cord-010092-uftc8inx 1524 9 donors donor NNS cord-010092-uftc8inx 1524 10 was be VBD cord-010092-uftc8inx 1524 11 estimated estimate VBN cord-010092-uftc8inx 1524 12 at at IN cord-010092-uftc8inx 1524 13 3,103 3,103 CD cord-010092-uftc8inx 1524 14 and and CC cord-010092-uftc8inx 1524 15 the the DT cord-010092-uftc8inx 1524 16 number number NN cord-010092-uftc8inx 1524 17 of of IN cord-010092-uftc8inx 1524 18 additional additional JJ cord-010092-uftc8inx 1524 19 HIV HIV NNP cord-010092-uftc8inx 1524 20 positive positive JJ cord-010092-uftc8inx 1524 21 donations donation NNS cord-010092-uftc8inx 1524 22 at at IN cord-010092-uftc8inx 1524 23 4.92 4.92 CD cord-010092-uftc8inx 1524 24 , , , cord-010092-uftc8inx 1524 25 resulting result VBG cord-010092-uftc8inx 1524 26 in in IN cord-010092-uftc8inx 1524 27 an an DT cord-010092-uftc8inx 1524 28 HIV HIV NNP cord-010092-uftc8inx 1524 29 RR RR NNP cord-010092-uftc8inx 1524 30 of of IN cord-010092-uftc8inx 1524 31 0.23 0.23 CD cord-010092-uftc8inx 1524 32 in in IN cord-010092-uftc8inx 1524 33 1 1 CD cord-010092-uftc8inx 1524 34 million million CD cord-010092-uftc8inx 1524 35 donations donation NNS cord-010092-uftc8inx 1524 36 [ [ -LRB- cord-010092-uftc8inx 1524 37 95 95 CD cord-010092-uftc8inx 1524 38 % % NN cord-010092-uftc8inx 1524 39 CI ci NN cord-010092-uftc8inx 1524 40 : : : cord-010092-uftc8inx 1524 41 0.05 0.05 CD cord-010092-uftc8inx 1524 42 - - HYPH cord-010092-uftc8inx 1524 43 0.56 0.56 CD cord-010092-uftc8inx 1524 44 ] ] -RRB- cord-010092-uftc8inx 1524 45 or or CC cord-010092-uftc8inx 1524 46 1 1 CD cord-010092-uftc8inx 1524 47 in in IN cord-010092-uftc8inx 1524 48 4,300,000 4,300,000 CD cord-010092-uftc8inx 1524 49 donations donation NNS cord-010092-uftc8inx 1524 50 . . . cord-010092-uftc8inx 1525 1 Sensitivity sensitivity NN cord-010092-uftc8inx 1525 2 analysis analysis NN cord-010092-uftc8inx 1525 3 shows show VBZ cord-010092-uftc8inx 1525 4 that that IN cord-010092-uftc8inx 1525 5 if if IN cord-010092-uftc8inx 1525 6 both both CC cord-010092-uftc8inx 1525 7 the the DT cord-010092-uftc8inx 1525 8 number number NN cord-010092-uftc8inx 1525 9 of of IN cord-010092-uftc8inx 1525 10 MSM MSM NNP cord-010092-uftc8inx 1525 11 and and CC cord-010092-uftc8inx 1525 12 the the DT cord-010092-uftc8inx 1525 13 HIV HIV NNP cord-010092-uftc8inx 1525 14 incidence incidence NN cord-010092-uftc8inx 1525 15 were be VBD cord-010092-uftc8inx 1525 16 multiplied multiply VBN cord-010092-uftc8inx 1525 17 by by IN cord-010092-uftc8inx 1525 18 1.5 1.5 CD cord-010092-uftc8inx 1525 19 , , , cord-010092-uftc8inx 1525 20 the the DT cord-010092-uftc8inx 1525 21 risk risk NN cord-010092-uftc8inx 1525 22 would would MD cord-010092-uftc8inx 1525 23 be be VB cord-010092-uftc8inx 1525 24 1 1 CD cord-010092-uftc8inx 1525 25 in in IN cord-010092-uftc8inx 1525 26 6,225,000 6,225,000 CD cord-010092-uftc8inx 1525 27 donations donation NNS cord-010092-uftc8inx 1525 28 for for IN cord-010092-uftc8inx 1525 29 S1 s1 NN cord-010092-uftc8inx 1525 30 , , , cord-010092-uftc8inx 1525 31 and and CC cord-010092-uftc8inx 1525 32 1 1 CD cord-010092-uftc8inx 1525 33 in in IN cord-010092-uftc8inx 1525 34 3,000,000 3,000,000 CD cord-010092-uftc8inx 1525 35 for for IN cord-010092-uftc8inx 1525 36 S2 S2 NNP cord-010092-uftc8inx 1525 37 . . . cord-010092-uftc8inx 1526 1 Summary Summary NNP cord-010092-uftc8inx 1526 2 / / SYM cord-010092-uftc8inx 1526 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 1526 4 : : : cord-010092-uftc8inx 1527 1 For for IN cord-010092-uftc8inx 1527 2 both both DT cord-010092-uftc8inx 1527 3 scenarios scenario NNS cord-010092-uftc8inx 1527 4 , , , cord-010092-uftc8inx 1527 5 the the DT cord-010092-uftc8inx 1527 6 HIV HIV NNP cord-010092-uftc8inx 1527 7 RR RR NNP cord-010092-uftc8inx 1527 8 remains remain VBZ cord-010092-uftc8inx 1527 9 very very RB cord-010092-uftc8inx 1527 10 low low JJ cord-010092-uftc8inx 1527 11 . . . cord-010092-uftc8inx 1528 1 For for IN cord-010092-uftc8inx 1528 2 S1 s1 NN cord-010092-uftc8inx 1528 3 ( ( -LRB- cord-010092-uftc8inx 1528 4 4-month 4-month JJ cord-010092-uftc8inx 1528 5 deferral deferral NN cord-010092-uftc8inx 1528 6 ) ) -RRB- cord-010092-uftc8inx 1528 7 , , , cord-010092-uftc8inx 1528 8 the the DT cord-010092-uftc8inx 1528 9 risk risk NN cord-010092-uftc8inx 1528 10 is be VBZ cord-010092-uftc8inx 1528 11 identical identical JJ cord-010092-uftc8inx 1528 12 to to IN cord-010092-uftc8inx 1528 13 the the DT cord-010092-uftc8inx 1528 14 baseline baseline JJ cord-010092-uftc8inx 1528 15 RR rr NN cord-010092-uftc8inx 1528 16 and and CC cord-010092-uftc8inx 1528 17 is be VBZ cord-010092-uftc8inx 1528 18 very very RB cord-010092-uftc8inx 1528 19 robust robust JJ cord-010092-uftc8inx 1528 20 to to IN cord-010092-uftc8inx 1528 21 variations variation NNS cord-010092-uftc8inx 1528 22 in in IN cord-010092-uftc8inx 1528 23 the the DT cord-010092-uftc8inx 1528 24 model model NN cord-010092-uftc8inx 1528 25 parameters parameter NNS cord-010092-uftc8inx 1528 26 . . . cord-010092-uftc8inx 1529 1 For for IN cord-010092-uftc8inx 1529 2 S2 S2 NNP cord-010092-uftc8inx 1529 3 ( ( -LRB- cord-010092-uftc8inx 1529 4 no no DT cord-010092-uftc8inx 1529 5 more more JJR cord-010092-uftc8inx 1529 6 than than IN cord-010092-uftc8inx 1529 7 one one CD cord-010092-uftc8inx 1529 8 sexual sexual JJ cord-010092-uftc8inx 1529 9 partner partner NN cord-010092-uftc8inx 1529 10 , , , cord-010092-uftc8inx 1529 11 4 4 CD cord-010092-uftc8inx 1529 12 months month NNS cord-010092-uftc8inx 1529 13 ) ) -RRB- cord-010092-uftc8inx 1529 14 , , , cord-010092-uftc8inx 1529 15 the the DT cord-010092-uftc8inx 1529 16 risk risk NN cord-010092-uftc8inx 1529 17 is be VBZ cord-010092-uftc8inx 1529 18 1.5 1.5 CD cord-010092-uftc8inx 1529 19 higher high JJR cord-010092-uftc8inx 1529 20 than than IN cord-010092-uftc8inx 1529 21 the the DT cord-010092-uftc8inx 1529 22 point point NN cord-010092-uftc8inx 1529 23 estimate estimate NN cord-010092-uftc8inx 1529 24 of of IN cord-010092-uftc8inx 1529 25 the the DT cord-010092-uftc8inx 1529 26 baseline baseline JJ cord-010092-uftc8inx 1529 27 RR rr NN cord-010092-uftc8inx 1529 28 and and CC cord-010092-uftc8inx 1529 29 sensitivity sensitivity NN cord-010092-uftc8inx 1529 30 analysis analysis NN cord-010092-uftc8inx 1529 31 shows show VBZ cord-010092-uftc8inx 1529 32 that that IN cord-010092-uftc8inx 1529 33 this this DT cord-010092-uftc8inx 1529 34 estimate estimate NN cord-010092-uftc8inx 1529 35 is be VBZ cord-010092-uftc8inx 1529 36 less less RBR cord-010092-uftc8inx 1529 37 robust robust JJ cord-010092-uftc8inx 1529 38 than than IN cord-010092-uftc8inx 1529 39 for for IN cord-010092-uftc8inx 1529 40 S1 s1 NN cord-010092-uftc8inx 1529 41 , , , cord-010092-uftc8inx 1529 42 since since IN cord-010092-uftc8inx 1529 43 the the DT cord-010092-uftc8inx 1529 44 risk risk NN cord-010092-uftc8inx 1529 45 could could MD cord-010092-uftc8inx 1529 46 be be VB cord-010092-uftc8inx 1529 47 2 2 CD cord-010092-uftc8inx 1529 48 times time NNS cord-010092-uftc8inx 1529 49 higher high JJR cord-010092-uftc8inx 1529 50 than than IN cord-010092-uftc8inx 1529 51 the the DT cord-010092-uftc8inx 1529 52 baseline baseline JJ cord-010092-uftc8inx 1529 53 RR rr NN cord-010092-uftc8inx 1529 54 . . . cord-010092-uftc8inx 1530 1 For for IN cord-010092-uftc8inx 1530 2 both both DT cord-010092-uftc8inx 1530 3 scenarios scenario NNS cord-010092-uftc8inx 1530 4 , , , cord-010092-uftc8inx 1530 5 there there EX cord-010092-uftc8inx 1530 6 was be VBD cord-010092-uftc8inx 1530 7 a a DT cord-010092-uftc8inx 1530 8 modest modest JJ cord-010092-uftc8inx 1530 9 increase increase NN cord-010092-uftc8inx 1530 10 in in IN cord-010092-uftc8inx 1530 11 eligible eligible JJ cord-010092-uftc8inx 1530 12 MSM MSM NNP cord-010092-uftc8inx 1530 13 donating donating NN cord-010092-uftc8inx 1530 14 . . . cord-010092-uftc8inx 1531 1 3D 3D NNP cord-010092-uftc8inx 1531 2 - - HYPH cord-010092-uftc8inx 1531 3 S13 S13 NNP cord-010092-uftc8inx 1531 4 - - HYPH cord-010092-uftc8inx 1531 5 03 03 CD cord-010092-uftc8inx 1531 6 Background Background NNP cord-010092-uftc8inx 1531 7 : : : cord-010092-uftc8inx 1532 1 Recruiting recruit VBG cord-010092-uftc8inx 1532 2 safe safe JJ cord-010092-uftc8inx 1532 3 blood blood NN cord-010092-uftc8inx 1532 4 donors donor NNS cord-010092-uftc8inx 1532 5 amongst amongst IN cord-010092-uftc8inx 1532 6 the the DT cord-010092-uftc8inx 1532 7 largest large JJS cord-010092-uftc8inx 1532 8 HIV HIV NNP cord-010092-uftc8inx 1532 9 - - HYPH cord-010092-uftc8inx 1532 10 positive positive JJ cord-010092-uftc8inx 1532 11 population population NN cord-010092-uftc8inx 1532 12 in in IN cord-010092-uftc8inx 1532 13 the the DT cord-010092-uftc8inx 1532 14 world world NN cord-010092-uftc8inx 1532 15 is be VBZ cord-010092-uftc8inx 1532 16 a a DT cord-010092-uftc8inx 1532 17 major major JJ cord-010092-uftc8inx 1532 18 challenge challenge NN cord-010092-uftc8inx 1532 19 for for IN cord-010092-uftc8inx 1532 20 South south JJ cord-010092-uftc8inx 1532 21 African african JJ cord-010092-uftc8inx 1532 22 blood blood NN cord-010092-uftc8inx 1532 23 transfusion transfusion NN cord-010092-uftc8inx 1532 24 services service NNS cord-010092-uftc8inx 1532 25 . . . cord-010092-uftc8inx 1533 1 South south JJ cord-010092-uftc8inx 1533 2 African african JJ cord-010092-uftc8inx 1533 3 donor donor NN cord-010092-uftc8inx 1533 4 deferral deferral NN cord-010092-uftc8inx 1533 5 criteria criterion NNS cord-010092-uftc8inx 1533 6 and and CC cord-010092-uftc8inx 1533 7 deferral deferral NN cord-010092-uftc8inx 1533 8 periods period NNS cord-010092-uftc8inx 1533 9 for for IN cord-010092-uftc8inx 1533 10 perceived perceive VBN cord-010092-uftc8inx 1533 11 high high JJ cord-010092-uftc8inx 1533 12 risk risk NN cord-010092-uftc8inx 1533 13 activities activity NNS cord-010092-uftc8inx 1533 14 have have VBP cord-010092-uftc8inx 1533 15 evolved evolve VBN cord-010092-uftc8inx 1533 16 over over IN cord-010092-uftc8inx 1533 17 time time NN cord-010092-uftc8inx 1533 18 , , , cord-010092-uftc8inx 1533 19 but but CC cord-010092-uftc8inx 1533 20 current current JJ cord-010092-uftc8inx 1533 21 risk risk NN cord-010092-uftc8inx 1533 22 factors factor NNS cord-010092-uftc8inx 1533 23 for for IN cord-010092-uftc8inx 1533 24 infection infection NN cord-010092-uftc8inx 1533 25 have have VBP cord-010092-uftc8inx 1533 26 not not RB cord-010092-uftc8inx 1533 27 been be VBN cord-010092-uftc8inx 1533 28 formally formally RB cord-010092-uftc8inx 1533 29 assessed assess VBN cord-010092-uftc8inx 1533 30 . . . cord-010092-uftc8inx 1534 1 In in IN cord-010092-uftc8inx 1534 2 addition addition NN cord-010092-uftc8inx 1534 3 , , , cord-010092-uftc8inx 1534 4 most most JJS cord-010092-uftc8inx 1534 5 studies study NNS cord-010092-uftc8inx 1534 6 have have VBP cord-010092-uftc8inx 1534 7 reported report VBN cord-010092-uftc8inx 1534 8 risk risk NN cord-010092-uftc8inx 1534 9 factors factor NNS cord-010092-uftc8inx 1534 10 for for IN cord-010092-uftc8inx 1534 11 prevalent prevalent JJ cord-010092-uftc8inx 1534 12 HIV HIV NNP cord-010092-uftc8inx 1534 13 infection infection NN cord-010092-uftc8inx 1534 14 whereas whereas IN cord-010092-uftc8inx 1534 15 risk risk NN cord-010092-uftc8inx 1534 16 behaviours behaviour NNS cord-010092-uftc8inx 1534 17 for for IN cord-010092-uftc8inx 1534 18 incident incident NN cord-010092-uftc8inx 1534 19 infection infection NN cord-010092-uftc8inx 1534 20 are be VBP cord-010092-uftc8inx 1534 21 more more RBR cord-010092-uftc8inx 1534 22 informative informative JJ cord-010092-uftc8inx 1534 23 as as IN cord-010092-uftc8inx 1534 24 donations donation NNS cord-010092-uftc8inx 1534 25 with with IN cord-010092-uftc8inx 1534 26 these these DT cord-010092-uftc8inx 1534 27 infections infection NNS cord-010092-uftc8inx 1534 28 could could MD cord-010092-uftc8inx 1534 29 occur occur VB cord-010092-uftc8inx 1534 30 during during IN cord-010092-uftc8inx 1534 31 the the DT cord-010092-uftc8inx 1534 32 window window NN cord-010092-uftc8inx 1534 33 periods period NNS cord-010092-uftc8inx 1534 34 of of IN cord-010092-uftc8inx 1534 35 available available JJ cord-010092-uftc8inx 1534 36 screening screening NN cord-010092-uftc8inx 1534 37 assays assay NNS cord-010092-uftc8inx 1534 38 . . . cord-010092-uftc8inx 1535 1 Aims aim VBZ cord-010092-uftc8inx 1535 2 : : : cord-010092-uftc8inx 1535 3 To to TO cord-010092-uftc8inx 1535 4 identify identify VB cord-010092-uftc8inx 1535 5 the the DT cord-010092-uftc8inx 1535 6 demographic demographic JJ cord-010092-uftc8inx 1535 7 and and CC cord-010092-uftc8inx 1535 8 behavioural behavioural JJ cord-010092-uftc8inx 1535 9 risk risk NN cord-010092-uftc8inx 1535 10 factors factor NNS cord-010092-uftc8inx 1535 11 associated associate VBN cord-010092-uftc8inx 1535 12 with with IN cord-010092-uftc8inx 1535 13 incident incident NN cord-010092-uftc8inx 1535 14 HIV HIV NNP cord-010092-uftc8inx 1535 15 infection infection NN cord-010092-uftc8inx 1535 16 among among IN cord-010092-uftc8inx 1535 17 blood blood NN cord-010092-uftc8inx 1535 18 donors donor NNS cord-010092-uftc8inx 1535 19 in in IN cord-010092-uftc8inx 1535 20 South South NNP cord-010092-uftc8inx 1535 21 Africa Africa NNP cord-010092-uftc8inx 1535 22 . . . cord-010092-uftc8inx 1536 1 Methods method NNS cord-010092-uftc8inx 1536 2 : : : cord-010092-uftc8inx 1536 3 We -PRON- PRP cord-010092-uftc8inx 1536 4 conducted conduct VBD cord-010092-uftc8inx 1536 5 a a DT cord-010092-uftc8inx 1536 6 case case NN cord-010092-uftc8inx 1536 7 - - HYPH cord-010092-uftc8inx 1536 8 control control NN cord-010092-uftc8inx 1536 9 study study NN cord-010092-uftc8inx 1536 10 with with IN cord-010092-uftc8inx 1536 11 incident incident NN cord-010092-uftc8inx 1536 12 HIV HIV NNP cord-010092-uftc8inx 1536 13 - - HYPH cord-010092-uftc8inx 1536 14 infected infect VBN cord-010092-uftc8inx 1536 15 blood blood NN cord-010092-uftc8inx 1536 16 donors donor NNS cord-010092-uftc8inx 1536 17 compared compare VBN cord-010092-uftc8inx 1536 18 to to IN cord-010092-uftc8inx 1536 19 infectious infectious JJ cord-010092-uftc8inx 1536 20 marker marker NN cord-010092-uftc8inx 1536 21 negative negative JJ cord-010092-uftc8inx 1536 22 controls control NNS cord-010092-uftc8inx 1536 23 . . . cord-010092-uftc8inx 1537 1 Incident incident NN cord-010092-uftc8inx 1537 2 HIV HIV NNP cord-010092-uftc8inx 1537 3 cases case NNS cord-010092-uftc8inx 1537 4 and and CC cord-010092-uftc8inx 1537 5 controls control VBZ cord-010092-uftc8inx 1537 6 seronegative seronegative JJ cord-010092-uftc8inx 1537 7 for for IN cord-010092-uftc8inx 1537 8 HIV HIV NNP cord-010092-uftc8inx 1537 9 , , , cord-010092-uftc8inx 1537 10 hepatitis hepatitis NN cord-010092-uftc8inx 1537 11 B B NNP cord-010092-uftc8inx 1537 12 and and CC cord-010092-uftc8inx 1537 13 C C NNP cord-010092-uftc8inx 1537 14 viruses virus NNS cord-010092-uftc8inx 1537 15 and and CC cord-010092-uftc8inx 1537 16 syphilis syphili NNS cord-010092-uftc8inx 1537 17 were be VBD cord-010092-uftc8inx 1537 18 accrued accrue VBN cord-010092-uftc8inx 1537 19 from from IN cord-010092-uftc8inx 1537 20 a a DT cord-010092-uftc8inx 1537 21 donor donor NN cord-010092-uftc8inx 1537 22 pool pool NN cord-010092-uftc8inx 1537 23 covering cover VBG cord-010092-uftc8inx 1537 24 8 8 CD cord-010092-uftc8inx 1537 25 of of IN cord-010092-uftc8inx 1537 26 9 9 CD cord-010092-uftc8inx 1537 27 provinces province NNS cord-010092-uftc8inx 1537 28 in in IN cord-010092-uftc8inx 1537 29 South South NNP cord-010092-uftc8inx 1537 30 Africa Africa NNP cord-010092-uftc8inx 1537 31 . . . cord-010092-uftc8inx 1538 1 Controls control NNS cord-010092-uftc8inx 1538 2 were be VBD cord-010092-uftc8inx 1538 3 frequency frequency NN cord-010092-uftc8inx 1538 4 matched match VBN cord-010092-uftc8inx 1538 5 at at IN cord-010092-uftc8inx 1538 6 a a DT cord-010092-uftc8inx 1538 7 3:1 3:1 CD cord-010092-uftc8inx 1538 8 ratio ratio NN cord-010092-uftc8inx 1538 9 to to IN cord-010092-uftc8inx 1538 10 cases case NNS cord-010092-uftc8inx 1538 11 on on IN cord-010092-uftc8inx 1538 12 race race NN cord-010092-uftc8inx 1538 13 , , , cord-010092-uftc8inx 1538 14 age age NN cord-010092-uftc8inx 1538 15 and and CC cord-010092-uftc8inx 1538 16 geography geography NN cord-010092-uftc8inx 1538 17 . . . cord-010092-uftc8inx 1539 1 Incident incident NN cord-010092-uftc8inx 1539 2 HIVinfections hivinfection NNS cord-010092-uftc8inx 1539 3 were be VBD cord-010092-uftc8inx 1539 4 HIV HIV NNP cord-010092-uftc8inx 1539 5 RNA RNA NNP cord-010092-uftc8inx 1539 6 positive positive JJ cord-010092-uftc8inx 1539 7 by by IN cord-010092-uftc8inx 1539 8 individual individual JJ cord-010092-uftc8inx 1539 9 donation donation NN cord-010092-uftc8inx 1539 10 nucleic nucleic VBD cord-010092-uftc8inx 1539 11 acid acid NN cord-010092-uftc8inx 1539 12 amplification amplification NN cord-010092-uftc8inx 1539 13 testing testing NN cord-010092-uftc8inx 1539 14 ( ( -LRB- cord-010092-uftc8inx 1539 15 ID ID NNP cord-010092-uftc8inx 1539 16 - - HYPH cord-010092-uftc8inx 1539 17 NAT NAT NNP cord-010092-uftc8inx 1539 18 ; ; : cord-010092-uftc8inx 1539 19 Procleix Procleix NNP cord-010092-uftc8inx 1539 20 , , , cord-010092-uftc8inx 1539 21 Grifols Grifols NNP cord-010092-uftc8inx 1539 22 ) ) -RRB- cord-010092-uftc8inx 1539 23 but but CC cord-010092-uftc8inx 1539 24 antibody antibody NN cord-010092-uftc8inx 1539 25 ( ( -LRB- cord-010092-uftc8inx 1539 26 Ab Ab NNP cord-010092-uftc8inx 1539 27 ) ) -RRB- cord-010092-uftc8inx 1539 28 negative negative JJ cord-010092-uftc8inx 1540 1 ( ( -LRB- cord-010092-uftc8inx 1540 2 PRISM PRISM NNP cord-010092-uftc8inx 1540 3 , , , cord-010092-uftc8inx 1540 4 Abbott Abbott NNP cord-010092-uftc8inx 1540 5 ) ) -RRB- cord-010092-uftc8inx 1540 6 as as RB cord-010092-uftc8inx 1540 7 well well RB cord-010092-uftc8inx 1540 8 as as IN cord-010092-uftc8inx 1540 9 those those DT cord-010092-uftc8inx 1540 10 RNA+/Ab+ RNA+/Ab+ NNS cord-010092-uftc8inx 1540 11 donors donor NNS cord-010092-uftc8inx 1540 12 with with IN cord-010092-uftc8inx 1540 13 recently recently RB cord-010092-uftc8inx 1540 14 - - HYPH cord-010092-uftc8inx 1540 15 acquired acquire VBN cord-010092-uftc8inx 1540 16 HIV HIV NNP cord-010092-uftc8inx 1540 17 based base VBN cord-010092-uftc8inx 1540 18 on on IN cord-010092-uftc8inx 1540 19 Limiting limit VBG cord-010092-uftc8inx 1540 20 Antigen Antigen NNP cord-010092-uftc8inx 1540 21 Avidity Avidity NNP cord-010092-uftc8inx 1540 22 ( ( -LRB- cord-010092-uftc8inx 1540 23 LAg LAg NNS cord-010092-uftc8inx 1540 24 ) ) -RRB- cord-010092-uftc8inx 1540 25 assay assay NN cord-010092-uftc8inx 1540 26 results result NNS cord-010092-uftc8inx 1540 27 with with IN cord-010092-uftc8inx 1540 28 normalized normalized JJ cord-010092-uftc8inx 1540 29 optical optical JJ cord-010092-uftc8inx 1540 30 density density NN cord-010092-uftc8inx 1540 31 values value NNS cord-010092-uftc8inx 1540 32 of of IN cord-010092-uftc8inx 1540 33 < < NNP cord-010092-uftc8inx 1540 34 1.5 1.5 CD cord-010092-uftc8inx 1540 35 . . . cord-010092-uftc8inx 1541 1 Eligible eligible JJ cord-010092-uftc8inx 1541 2 cases case NNS cord-010092-uftc8inx 1541 3 and and CC cord-010092-uftc8inx 1541 4 controls control NNS cord-010092-uftc8inx 1541 5 completed complete VBD cord-010092-uftc8inx 1541 6 a a DT cord-010092-uftc8inx 1541 7 confidential confidential JJ cord-010092-uftc8inx 1541 8 audio audio JJ cord-010092-uftc8inx 1541 9 computer computer NN cord-010092-uftc8inx 1541 10 assisted assist VBD cord-010092-uftc8inx 1541 11 structured structured JJ cord-010092-uftc8inx 1541 12 interview interview NN cord-010092-uftc8inx 1541 13 ( ( -LRB- cord-010092-uftc8inx 1541 14 ACASI ACASI NNP cord-010092-uftc8inx 1541 15 ) ) -RRB- cord-010092-uftc8inx 1541 16 on on IN cord-010092-uftc8inx 1541 17 motivations motivation NNS cord-010092-uftc8inx 1541 18 for for IN cord-010092-uftc8inx 1541 19 blood blood NN cord-010092-uftc8inx 1541 20 donation donation NN cord-010092-uftc8inx 1541 21 and and CC cord-010092-uftc8inx 1541 22 behavioural behavioural JJ cord-010092-uftc8inx 1541 23 factors factor NNS cord-010092-uftc8inx 1541 24 , , , cord-010092-uftc8inx 1541 25 including include VBG cord-010092-uftc8inx 1541 26 behaviours behaviour NNS cord-010092-uftc8inx 1541 27 in in IN cord-010092-uftc8inx 1541 28 the the DT cord-010092-uftc8inx 1541 29 6 6 CD cord-010092-uftc8inx 1541 30 months month NNS cord-010092-uftc8inx 1541 31 before before IN cord-010092-uftc8inx 1541 32 donation donation NN cord-010092-uftc8inx 1541 33 . . . cord-010092-uftc8inx 1542 1 Frequencies frequency NNS cord-010092-uftc8inx 1542 2 and and CC cord-010092-uftc8inx 1542 3 measures measure NNS cord-010092-uftc8inx 1542 4 of of IN cord-010092-uftc8inx 1542 5 statistical statistical JJ cord-010092-uftc8inx 1542 6 association association NN cord-010092-uftc8inx 1542 7 for for IN cord-010092-uftc8inx 1542 8 risk risk NN cord-010092-uftc8inx 1542 9 behaviours behaviour NNS cord-010092-uftc8inx 1542 10 comparing compare VBG cord-010092-uftc8inx 1542 11 cases case NNS cord-010092-uftc8inx 1542 12 and and CC cord-010092-uftc8inx 1542 13 controls control NNS cord-010092-uftc8inx 1542 14 are be VBP cord-010092-uftc8inx 1542 15 reported report VBN cord-010092-uftc8inx 1542 16 after after IN cord-010092-uftc8inx 1542 17 adjusting adjust VBG cord-010092-uftc8inx 1542 18 for for IN cord-010092-uftc8inx 1542 19 multiple multiple JJ cord-010092-uftc8inx 1542 20 comparisons comparison NNS cord-010092-uftc8inx 1542 21 . . . cord-010092-uftc8inx 1543 1 Results result NNS cord-010092-uftc8inx 1543 2 : : : cord-010092-uftc8inx 1544 1 From from IN cord-010092-uftc8inx 1544 2 November November NNP cord-010092-uftc8inx 1544 3 2014 2014 CD cord-010092-uftc8inx 1544 4 to to IN cord-010092-uftc8inx 1544 5 January January NNP cord-010092-uftc8inx 1544 6 2018 2018 CD cord-010092-uftc8inx 1544 7 , , , cord-010092-uftc8inx 1544 8 we -PRON- PRP cord-010092-uftc8inx 1544 9 enrolled enrol VBD cord-010092-uftc8inx 1544 10 323 323 CD cord-010092-uftc8inx 1544 11 incident incident NN cord-010092-uftc8inx 1544 12 HIV HIV NNP cord-010092-uftc8inx 1544 13 cases case NNS cord-010092-uftc8inx 1544 14 and and CC cord-010092-uftc8inx 1544 15 877 877 CD cord-010092-uftc8inx 1544 16 controls control NNS cord-010092-uftc8inx 1544 17 ; ; : cord-010092-uftc8inx 1544 18 202 202 CD cord-010092-uftc8inx 1544 19 ( ( -LRB- cord-010092-uftc8inx 1544 20 62.5 62.5 CD cord-010092-uftc8inx 1544 21 % % NN cord-010092-uftc8inx 1544 22 ) ) -RRB- cord-010092-uftc8inx 1544 23 cases case NNS cord-010092-uftc8inx 1544 24 and and CC cord-010092-uftc8inx 1544 25 544 544 CD cord-010092-uftc8inx 1544 26 ( ( -LRB- cord-010092-uftc8inx 1544 27 62 62 CD cord-010092-uftc8inx 1544 28 % % NN cord-010092-uftc8inx 1544 29 ) ) -RRB- cord-010092-uftc8inx 1544 30 controls control NNS cord-010092-uftc8inx 1544 31 were be VBD cord-010092-uftc8inx 1544 32 ≤ ≤ NNP cord-010092-uftc8inx 1544 33 29 29 CD cord-010092-uftc8inx 1544 34 years year NNS cord-010092-uftc8inx 1544 35 old old JJ cord-010092-uftc8inx 1544 36 . . . cord-010092-uftc8inx 1545 1 There there EX cord-010092-uftc8inx 1545 2 were be VBD cord-010092-uftc8inx 1545 3 significantly significantly RB cord-010092-uftc8inx 1545 4 more more JJR cord-010092-uftc8inx 1545 5 female female JJ cord-010092-uftc8inx 1545 6 cases case NNS cord-010092-uftc8inx 1545 7 230 230 CD cord-010092-uftc8inx 1545 8 ( ( -LRB- cord-010092-uftc8inx 1545 9 71.2 71.2 CD cord-010092-uftc8inx 1545 10 % % NN cord-010092-uftc8inx 1545 11 ) ) -RRB- cord-010092-uftc8inx 1545 12 than than IN cord-010092-uftc8inx 1545 13 female female JJ cord-010092-uftc8inx 1545 14 controls control NNS cord-010092-uftc8inx 1545 15 439 439 CD cord-010092-uftc8inx 1545 16 ( ( -LRB- cord-010092-uftc8inx 1545 17 50.1 50.1 CD cord-010092-uftc8inx 1545 18 % % NN cord-010092-uftc8inx 1545 19 ) ) -RRB- cord-010092-uftc8inx 1546 1 ( ( -LRB- cord-010092-uftc8inx 1546 2 P p NN cord-010092-uftc8inx 1546 3 < < XX cord-010092-uftc8inx 1546 4 0.0001 0.0001 CD cord-010092-uftc8inx 1546 5 ) ) -RRB- cord-010092-uftc8inx 1546 6 . . . cord-010092-uftc8inx 1547 1 Significant significant JJ cord-010092-uftc8inx 1547 2 HIV HIV NNP cord-010092-uftc8inx 1547 3 risk risk NN cord-010092-uftc8inx 1547 4 factors factor NNS cord-010092-uftc8inx 1547 5 ( ( -LRB- cord-010092-uftc8inx 1547 6 all all DT cord-010092-uftc8inx 1547 7 P p NN cord-010092-uftc8inx 1547 8 < < XX cord-010092-uftc8inx 1547 9 0.0001 0.0001 CD cord-010092-uftc8inx 1547 10 ) ) -RRB- cord-010092-uftc8inx 1547 11 reported report VBD cord-010092-uftc8inx 1547 12 within within IN cord-010092-uftc8inx 1547 13 the the DT cord-010092-uftc8inx 1547 14 6-months 6-months CD cord-010092-uftc8inx 1547 15 before before IN cord-010092-uftc8inx 1547 16 donation donation NN cord-010092-uftc8inx 1547 17 included include VBD cord-010092-uftc8inx 1547 18 : : : cord-010092-uftc8inx 1547 19 having have VBG cord-010092-uftc8inx 1547 20 a a DT cord-010092-uftc8inx 1547 21 primary primary JJ cord-010092-uftc8inx 1547 22 sex sex NN cord-010092-uftc8inx 1547 23 partner partner NN cord-010092-uftc8inx 1547 24 who who WP cord-010092-uftc8inx 1547 25 is be VBZ cord-010092-uftc8inx 1547 26 male male JJ cord-010092-uftc8inx 1547 27 ; ; , cord-010092-uftc8inx 1547 28 reporting report VBG cord-010092-uftc8inx 1547 29 increasing increase VBG cord-010092-uftc8inx 1547 30 numbers number NNS cord-010092-uftc8inx 1547 31 of of IN cord-010092-uftc8inx 1547 32 male male JJ cord-010092-uftc8inx 1547 33 sexual sexual JJ cord-010092-uftc8inx 1547 34 partners partner NNS cord-010092-uftc8inx 1547 35 for for IN cord-010092-uftc8inx 1547 36 both both DT cord-010092-uftc8inx 1547 37 females female NNS cord-010092-uftc8inx 1547 38 and and CC cord-010092-uftc8inx 1547 39 males male NNS cord-010092-uftc8inx 1547 40 ; ; : cord-010092-uftc8inx 1547 41 frequency frequency NN cord-010092-uftc8inx 1547 42 of of IN cord-010092-uftc8inx 1547 43 vaginal vaginal JJ cord-010092-uftc8inx 1547 44 sex sex NN cord-010092-uftc8inx 1547 45 ; ; , cord-010092-uftc8inx 1547 46 frequency frequency NN cord-010092-uftc8inx 1547 47 of of IN cord-010092-uftc8inx 1547 48 vaginal vaginal JJ cord-010092-uftc8inx 1547 49 sex sex NN cord-010092-uftc8inx 1547 50 without without IN cord-010092-uftc8inx 1547 51 condoms condom NNS cord-010092-uftc8inx 1547 52 ; ; : cord-010092-uftc8inx 1547 53 use use NN cord-010092-uftc8inx 1547 54 of of IN cord-010092-uftc8inx 1547 55 methods method NNS cord-010092-uftc8inx 1547 56 to to TO cord-010092-uftc8inx 1547 57 clean clean VB cord-010092-uftc8inx 1547 58 , , , cord-010092-uftc8inx 1547 59 dry dry JJ cord-010092-uftc8inx 1547 60 , , , cord-010092-uftc8inx 1547 61 or or CC cord-010092-uftc8inx 1547 62 tighten tighten VB cord-010092-uftc8inx 1547 63 one one PRP cord-010092-uftc8inx 1547 64 's 's POS cord-010092-uftc8inx 1547 65 anus anus NN cord-010092-uftc8inx 1547 66 before before IN cord-010092-uftc8inx 1547 67 sex sex NN cord-010092-uftc8inx 1547 68 ; ; : cord-010092-uftc8inx 1547 69 and and CC cord-010092-uftc8inx 1547 70 having have VBG cord-010092-uftc8inx 1547 71 visited visit VBN cord-010092-uftc8inx 1547 72 a a DT cord-010092-uftc8inx 1547 73 traditional traditional JJ cord-010092-uftc8inx 1547 74 healer healer NN cord-010092-uftc8inx 1547 75 for for IN cord-010092-uftc8inx 1547 76 medical medical JJ cord-010092-uftc8inx 1547 77 care care NN cord-010092-uftc8inx 1547 78 . . . cord-010092-uftc8inx 1548 1 Lack lack NN cord-010092-uftc8inx 1548 2 of of IN cord-010092-uftc8inx 1548 3 medical medical JJ cord-010092-uftc8inx 1548 4 aid aid NN cord-010092-uftc8inx 1548 5 ( ( -LRB- cord-010092-uftc8inx 1548 6 private private JJ cord-010092-uftc8inx 1548 7 health health NN cord-010092-uftc8inx 1548 8 insurance insurance NN cord-010092-uftc8inx 1548 9 ) ) -RRB- cord-010092-uftc8inx 1548 10 and and CC cord-010092-uftc8inx 1548 11 reports report NNS cord-010092-uftc8inx 1548 12 of of IN cord-010092-uftc8inx 1548 13 injury injury NN cord-010092-uftc8inx 1548 14 or or CC cord-010092-uftc8inx 1548 15 accident accident NN cord-010092-uftc8inx 1548 16 with with IN cord-010092-uftc8inx 1548 17 blood blood NN cord-010092-uftc8inx 1548 18 loss loss NN cord-010092-uftc8inx 1548 19 were be VBD cord-010092-uftc8inx 1548 20 also also RB cord-010092-uftc8inx 1548 21 associated associate VBN cord-010092-uftc8inx 1548 22 with with IN cord-010092-uftc8inx 1548 23 an an DT cord-010092-uftc8inx 1548 24 incident incident NN cord-010092-uftc8inx 1548 25 HIV HIV NNP cord-010092-uftc8inx 1548 26 infection infection NN cord-010092-uftc8inx 1548 27 . . . cord-010092-uftc8inx 1549 1 Summary Summary NNP cord-010092-uftc8inx 1549 2 / / SYM cord-010092-uftc8inx 1549 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 1549 4 : : : cord-010092-uftc8inx 1550 1 Our -PRON- PRP$ cord-010092-uftc8inx 1550 2 study study NN cord-010092-uftc8inx 1550 3 has have VBZ cord-010092-uftc8inx 1550 4 identified identify VBN cord-010092-uftc8inx 1550 5 a a DT cord-010092-uftc8inx 1550 6 set set NN cord-010092-uftc8inx 1550 7 of of IN cord-010092-uftc8inx 1550 8 novel novel NN cord-010092-uftc8inx 1550 9 , , , cord-010092-uftc8inx 1550 10 putative putative JJ cord-010092-uftc8inx 1550 11 risk risk NN cord-010092-uftc8inx 1550 12 factors factor NNS cord-010092-uftc8inx 1550 13 for for IN cord-010092-uftc8inx 1550 14 incident incident NN cord-010092-uftc8inx 1550 15 HIV HIV NNP cord-010092-uftc8inx 1550 16 infection infection NN cord-010092-uftc8inx 1550 17 among among IN cord-010092-uftc8inx 1550 18 South south JJ cord-010092-uftc8inx 1550 19 African african JJ cord-010092-uftc8inx 1550 20 blood blood NN cord-010092-uftc8inx 1550 21 donors donor NNS cord-010092-uftc8inx 1550 22 while while IN cord-010092-uftc8inx 1550 23 confirming confirm VBG cord-010092-uftc8inx 1550 24 a a DT cord-010092-uftc8inx 1550 25 number number NN cord-010092-uftc8inx 1550 26 of of IN cord-010092-uftc8inx 1550 27 previously previously RB cord-010092-uftc8inx 1550 28 known know VBN cord-010092-uftc8inx 1550 29 sexual sexual JJ cord-010092-uftc8inx 1550 30 risk risk NN cord-010092-uftc8inx 1550 31 behaviours behaviour NNS cord-010092-uftc8inx 1550 32 . . . cord-010092-uftc8inx 1551 1 Not not RB cord-010092-uftc8inx 1551 2 having have VBG cord-010092-uftc8inx 1551 3 private private JJ cord-010092-uftc8inx 1551 4 health health NN cord-010092-uftc8inx 1551 5 insurance insurance NN cord-010092-uftc8inx 1551 6 and and CC cord-010092-uftc8inx 1551 7 being be VBG cord-010092-uftc8inx 1551 8 injured injure VBN cord-010092-uftc8inx 1551 9 may may MD cord-010092-uftc8inx 1551 10 be be VB cord-010092-uftc8inx 1551 11 markers marker NNS cord-010092-uftc8inx 1551 12 of of IN cord-010092-uftc8inx 1551 13 socio socio JJ cord-010092-uftc8inx 1551 14 - - HYPH cord-010092-uftc8inx 1551 15 economic economic JJ cord-010092-uftc8inx 1551 16 context context NN cord-010092-uftc8inx 1551 17 that that WDT cord-010092-uftc8inx 1551 18 place place VBP cord-010092-uftc8inx 1551 19 individuals individual NNS cord-010092-uftc8inx 1551 20 at at IN cord-010092-uftc8inx 1551 21 higher high JJR cord-010092-uftc8inx 1551 22 risk risk NN cord-010092-uftc8inx 1551 23 rather rather RB cord-010092-uftc8inx 1551 24 than than IN cord-010092-uftc8inx 1551 25 behaviours behaviour NNS cord-010092-uftc8inx 1551 26 that that WDT cord-010092-uftc8inx 1551 27 directly directly RB cord-010092-uftc8inx 1551 28 increase increase VB cord-010092-uftc8inx 1551 29 HIV HIV NNP cord-010092-uftc8inx 1551 30 transmission transmission NN cord-010092-uftc8inx 1551 31 risk risk NN cord-010092-uftc8inx 1551 32 . . . cord-010092-uftc8inx 1552 1 The the DT cord-010092-uftc8inx 1552 2 detection detection NN cord-010092-uftc8inx 1552 3 of of IN cord-010092-uftc8inx 1552 4 risk risk NN cord-010092-uftc8inx 1552 5 behaviours behaviour NNS cord-010092-uftc8inx 1552 6 by by IN cord-010092-uftc8inx 1552 7 ACASI ACASI NNP cord-010092-uftc8inx 1552 8 in in IN cord-010092-uftc8inx 1552 9 donors donor NNS cord-010092-uftc8inx 1552 10 who who WP cord-010092-uftc8inx 1552 11 passed pass VBD cord-010092-uftc8inx 1552 12 predonation predonation NN cord-010092-uftc8inx 1552 13 questionnaires questionnaire NNS cord-010092-uftc8inx 1552 14 and and CC cord-010092-uftc8inx 1552 15 interviews interview NNS cord-010092-uftc8inx 1552 16 suggests suggest VBZ cord-010092-uftc8inx 1552 17 that that IN cord-010092-uftc8inx 1552 18 ACASI ACASI NNP cord-010092-uftc8inx 1552 19 has have VBZ cord-010092-uftc8inx 1552 20 the the DT cord-010092-uftc8inx 1552 21 potential potential NN cord-010092-uftc8inx 1552 22 to to TO cord-010092-uftc8inx 1552 23 improve improve VB cord-010092-uftc8inx 1552 24 risk risk NN cord-010092-uftc8inx 1552 25 behaviour behaviour NN cord-010092-uftc8inx 1552 26 identification identification NN cord-010092-uftc8inx 1552 27 . . . cord-010092-uftc8inx 1553 1 Background background NN cord-010092-uftc8inx 1553 2 : : : cord-010092-uftc8inx 1554 1 In in IN cord-010092-uftc8inx 1554 2 France France NNP cord-010092-uftc8inx 1554 3 from from IN cord-010092-uftc8inx 1554 4 2000 2000 CD cord-010092-uftc8inx 1554 5 to to IN cord-010092-uftc8inx 1554 6 2016 2016 CD cord-010092-uftc8inx 1554 7 , , , cord-010092-uftc8inx 1554 8 among among IN cord-010092-uftc8inx 1554 9 male male JJ cord-010092-uftc8inx 1554 10 blood blood NN cord-010092-uftc8inx 1554 11 donors donor NNS cord-010092-uftc8inx 1554 12 ( ( -LRB- cord-010092-uftc8inx 1554 13 mBDs mbds NN cord-010092-uftc8inx 1554 14 ) ) -RRB- cord-010092-uftc8inx 1554 15 found find VBD cord-010092-uftc8inx 1554 16 HIV-1 HIV-1 NNP cord-010092-uftc8inx 1554 17 positive positive JJ cord-010092-uftc8inx 1554 18 at at IN cord-010092-uftc8inx 1554 19 blood blood NN cord-010092-uftc8inx 1554 20 donation donation NN cord-010092-uftc8inx 1554 21 screening screening NN cord-010092-uftc8inx 1554 22 , , , cord-010092-uftc8inx 1554 23 31 31 CD cord-010092-uftc8inx 1554 24 % % NN cord-010092-uftc8inx 1554 25 did do VBD cord-010092-uftc8inx 1554 26 not not RB cord-010092-uftc8inx 1554 27 disclose disclose VB cord-010092-uftc8inx 1554 28 any any DT cord-010092-uftc8inx 1554 29 risk risk NN cord-010092-uftc8inx 1554 30 factor factor NN cord-010092-uftc8inx 1554 31 for for IN cord-010092-uftc8inx 1554 32 HIV HIV NNP cord-010092-uftc8inx 1554 33 infection infection NN cord-010092-uftc8inx 1554 34 during during IN cord-010092-uftc8inx 1554 35 post post JJ cord-010092-uftc8inx 1554 36 - - JJ cord-010092-uftc8inx 1554 37 donation donation NN cord-010092-uftc8inx 1554 38 interviews interview NNS cord-010092-uftc8inx 1554 39 , , , cord-010092-uftc8inx 1554 40 while while IN cord-010092-uftc8inx 1554 41 38 38 CD cord-010092-uftc8inx 1554 42 % % NN cord-010092-uftc8inx 1554 43 reported report VBD cord-010092-uftc8inx 1554 44 having have VBG cord-010092-uftc8inx 1554 45 sex sex NN cord-010092-uftc8inx 1554 46 with with IN cord-010092-uftc8inx 1554 47 men man NNS cord-010092-uftc8inx 1554 48 ( ( -LRB- cord-010092-uftc8inx 1554 49 MSM MSM NNP cord-010092-uftc8inx 1554 50 ) ) -RRB- cord-010092-uftc8inx 1554 51 , , , cord-010092-uftc8inx 1554 52 and and CC cord-010092-uftc8inx 1554 53 24 24 CD cord-010092-uftc8inx 1554 54 % % NN cord-010092-uftc8inx 1554 55 and and CC cord-010092-uftc8inx 1554 56 7 7 CD cord-010092-uftc8inx 1554 57 % % NN cord-010092-uftc8inx 1554 58 reported report VBD cord-010092-uftc8inx 1554 59 heterosexual heterosexual JJ cord-010092-uftc8inx 1554 60 sex sex NN cord-010092-uftc8inx 1554 61 ( ( -LRB- cord-010092-uftc8inx 1554 62 HTS HTS NNP cord-010092-uftc8inx 1554 63 ) ) -RRB- cord-010092-uftc8inx 1554 64 and and CC cord-010092-uftc8inx 1554 65 other other JJ cord-010092-uftc8inx 1554 66 risk risk NN cord-010092-uftc8inx 1554 67 factors factor NNS cord-010092-uftc8inx 1554 68 , , , cord-010092-uftc8inx 1554 69 respectively respectively RB cord-010092-uftc8inx 1554 70 . . . cord-010092-uftc8inx 1555 1 Aims aim VBZ cord-010092-uftc8inx 1555 2 : : : cord-010092-uftc8inx 1556 1 In in IN cord-010092-uftc8inx 1556 2 order order NN cord-010092-uftc8inx 1556 3 to to TO cord-010092-uftc8inx 1556 4 gain gain VB cord-010092-uftc8inx 1556 5 new new JJ cord-010092-uftc8inx 1556 6 insights insight NNS cord-010092-uftc8inx 1556 7 into into IN cord-010092-uftc8inx 1556 8 the the DT cord-010092-uftc8inx 1556 9 risk risk NN cord-010092-uftc8inx 1556 10 factors factor NNS cord-010092-uftc8inx 1556 11 for for IN cord-010092-uftc8inx 1556 12 HIV-1 HIV-1 NNP cord-010092-uftc8inx 1556 13 infection infection NN cord-010092-uftc8inx 1556 14 in in IN cord-010092-uftc8inx 1556 15 mBDs mbds NN cord-010092-uftc8inx 1556 16 , , , cord-010092-uftc8inx 1556 17 we -PRON- PRP cord-010092-uftc8inx 1556 18 performed perform VBD cord-010092-uftc8inx 1556 19 an an DT cord-010092-uftc8inx 1556 20 HIV-1 HIV-1 NNP cord-010092-uftc8inx 1556 21 genetic genetic JJ cord-010092-uftc8inx 1556 22 network network NN cord-010092-uftc8inx 1556 23 analysis analysis NN cord-010092-uftc8inx 1556 24 , , , cord-010092-uftc8inx 1556 25 including include VBG cord-010092-uftc8inx 1556 26 HIV-1 HIV-1 NNP cord-010092-uftc8inx 1557 1 positive positive JJ cord-010092-uftc8inx 1557 2 mBDs mbds NN cord-010092-uftc8inx 1557 3 and and CC cord-010092-uftc8inx 1557 4 patients patient NNS cord-010092-uftc8inx 1557 5 included include VBN cord-010092-uftc8inx 1557 6 in in IN cord-010092-uftc8inx 1557 7 the the DT cord-010092-uftc8inx 1557 8 French french JJ cord-010092-uftc8inx 1557 9 primary primary JJ cord-010092-uftc8inx 1557 10 HIV HIV NNP cord-010092-uftc8inx 1557 11 infection infection NN cord-010092-uftc8inx 1557 12 ANRS ANRS NNP cord-010092-uftc8inx 1557 13 CO6 co6 NN cord-010092-uftc8inx 1557 14 PRIMO PRIMO NNP cord-010092-uftc8inx 1557 15 cohort cohort NN cord-010092-uftc8inx 1557 16 ( ( -LRB- cord-010092-uftc8inx 1557 17 PC pc NN cord-010092-uftc8inx 1557 18 ) ) -RRB- cord-010092-uftc8inx 1557 19 . . . cord-010092-uftc8inx 1558 1 Methods method NNS cord-010092-uftc8inx 1558 2 : : : cord-010092-uftc8inx 1558 3 284 284 CD cord-010092-uftc8inx 1558 4 mBDs mbds NN cord-010092-uftc8inx 1558 5 , , , cord-010092-uftc8inx 1558 6 who who WP cord-010092-uftc8inx 1558 7 donated donate VBD cord-010092-uftc8inx 1558 8 blood blood NN cord-010092-uftc8inx 1558 9 between between IN cord-010092-uftc8inx 1558 10 2000 2000 CD cord-010092-uftc8inx 1558 11 and and CC cord-010092-uftc8inx 1558 12 2016 2016 CD cord-010092-uftc8inx 1558 13 , , , cord-010092-uftc8inx 1558 14 and and CC cord-010092-uftc8inx 1558 15 1340 1340 CD cord-010092-uftc8inx 1558 16 PCs pc NNS cord-010092-uftc8inx 1558 17 , , , cord-010092-uftc8inx 1558 18 included include VBN cord-010092-uftc8inx 1558 19 between between IN cord-010092-uftc8inx 1558 20 1998 1998 CD cord-010092-uftc8inx 1558 21 and and CC cord-010092-uftc8inx 1558 22 2014 2014 CD cord-010092-uftc8inx 1558 23 , , , cord-010092-uftc8inx 1558 24 were be VBD cord-010092-uftc8inx 1558 25 studied study VBN cord-010092-uftc8inx 1558 26 . . . cord-010092-uftc8inx 1559 1 Epidemiological epidemiological JJ cord-010092-uftc8inx 1559 2 data datum NNS cord-010092-uftc8inx 1559 3 were be VBD cord-010092-uftc8inx 1559 4 collected collect VBN cord-010092-uftc8inx 1559 5 by by IN cord-010092-uftc8inx 1559 6 the the DT cord-010092-uftc8inx 1559 7 French French NNP cord-010092-uftc8inx 1559 8 Blood Blood NNP cord-010092-uftc8inx 1559 9 Service Service NNP cord-010092-uftc8inx 1559 10 ( ( -LRB- cord-010092-uftc8inx 1559 11 EFS EFS NNP cord-010092-uftc8inx 1559 12 ) ) -RRB- cord-010092-uftc8inx 1559 13 upon upon IN cord-010092-uftc8inx 1559 14 blood blood NN cord-010092-uftc8inx 1559 15 donation donation NN cord-010092-uftc8inx 1559 16 or or CC cord-010092-uftc8inx 1559 17 post post JJ cord-010092-uftc8inx 1559 18 - - JJ cord-010092-uftc8inx 1559 19 donation donation NN cord-010092-uftc8inx 1559 20 interviews interview NNS cord-010092-uftc8inx 1559 21 for for IN cord-010092-uftc8inx 1559 22 mBDs mbds NN cord-010092-uftc8inx 1559 23 , , , cord-010092-uftc8inx 1559 24 and and CC cord-010092-uftc8inx 1559 25 upon upon IN cord-010092-uftc8inx 1559 26 inclusion inclusion NN cord-010092-uftc8inx 1559 27 for for IN cord-010092-uftc8inx 1559 28 CPs cp NNS cord-010092-uftc8inx 1559 29 . . . cord-010092-uftc8inx 1560 1 Viral viral JJ cord-010092-uftc8inx 1560 2 strains strain NNS cord-010092-uftc8inx 1560 3 were be VBD cord-010092-uftc8inx 1560 4 sequenced sequence VBN cord-010092-uftc8inx 1560 5 and and CC cord-010092-uftc8inx 1560 6 genotyped genotype VBN cord-010092-uftc8inx 1560 7 in in IN cord-010092-uftc8inx 1560 8 pol pol NN cord-010092-uftc8inx 1560 9 gene gene NN cord-010092-uftc8inx 1560 10 , , , cord-010092-uftc8inx 1560 11 and and CC cord-010092-uftc8inx 1560 12 a a DT cord-010092-uftc8inx 1560 13 recent recent JJ cord-010092-uftc8inx 1560 14 infection infection NN cord-010092-uftc8inx 1560 15 assay assay NN cord-010092-uftc8inx 1560 16 was be VBD cord-010092-uftc8inx 1560 17 performed perform VBN cord-010092-uftc8inx 1560 18 to to IN cord-010092-uftc8inx 1560 19 date date NN cord-010092-uftc8inx 1560 20 infection infection NN cord-010092-uftc8inx 1560 21 in in IN cord-010092-uftc8inx 1560 22 mBDs mbds NN cord-010092-uftc8inx 1561 1 ( ( -LRB- cord-010092-uftc8inx 1561 2 recent recent JJ cord-010092-uftc8inx 1561 3 : : : cord-010092-uftc8inx 1561 4 < < XX cord-010092-uftc8inx 1561 5 6 6 CD cord-010092-uftc8inx 1561 6 months month NNS cord-010092-uftc8inx 1561 7 ) ) -RRB- cord-010092-uftc8inx 1561 8 . . . cord-010092-uftc8inx 1562 1 A a DT cord-010092-uftc8inx 1562 2 partial partial JJ cord-010092-uftc8inx 1562 3 transmission transmission NN cord-010092-uftc8inx 1562 4 network network NN cord-010092-uftc8inx 1562 5 was be VBD cord-010092-uftc8inx 1562 6 computed compute VBN cord-010092-uftc8inx 1562 7 based base VBN cord-010092-uftc8inx 1562 8 on on IN cord-010092-uftc8inx 1562 9 Tamura Tamura NNP cord-010092-uftc8inx 1562 10 - - HYPH cord-010092-uftc8inx 1562 11 Nei Nei NNP cord-010092-uftc8inx 1562 12 93 93 CD cord-010092-uftc8inx 1562 13 nucleotidic nucleotidic JJ cord-010092-uftc8inx 1562 14 distance distance NN cord-010092-uftc8inx 1562 15 ( ( -LRB- cord-010092-uftc8inx 1562 16 threshold threshold NN cord-010092-uftc8inx 1562 17 for for IN cord-010092-uftc8inx 1562 18 HIV-1 HIV-1 NNP cord-010092-uftc8inx 1562 19 s s POS cord-010092-uftc8inx 1562 20 / / SYM cord-010092-uftc8inx 1562 21 t t NN cord-010092-uftc8inx 1562 22 B b NN cord-010092-uftc8inx 1562 23 = = SYM cord-010092-uftc8inx 1562 24 1.5 1.5 CD cord-010092-uftc8inx 1562 25 % % NN cord-010092-uftc8inx 1562 26 ; ; , cord-010092-uftc8inx 1562 27 for for IN cord-010092-uftc8inx 1562 28 non non JJ cord-010092-uftc8inx 1562 29 - - JJ cord-010092-uftc8inx 1562 30 B b JJ cord-010092-uftc8inx 1562 31 s/ s/ NN cord-010092-uftc8inx 1562 32 t t NN cord-010092-uftc8inx 1562 33 = = SYM cord-010092-uftc8inx 1562 34 0.8 0.8 CD cord-010092-uftc8inx 1562 35 % % NN cord-010092-uftc8inx 1562 36 ) ) -RRB- cord-010092-uftc8inx 1562 37 and and CC cord-010092-uftc8inx 1562 38 assortative assortative NN cord-010092-uftc8inx 1562 39 mixing mixing NN cord-010092-uftc8inx 1562 40 was be VBD cord-010092-uftc8inx 1562 41 evaluated evaluate VBN cord-010092-uftc8inx 1562 42 for for IN cord-010092-uftc8inx 1562 43 mBDs mbds FW cord-010092-uftc8inx 1562 44 epidemiological epidemiological JJ cord-010092-uftc8inx 1562 45 data datum NNS cord-010092-uftc8inx 1562 46 , , , cord-010092-uftc8inx 1562 47 including include VBG cord-010092-uftc8inx 1562 48 risk risk NN cord-010092-uftc8inx 1562 49 factors factor NNS cord-010092-uftc8inx 1562 50 for for IN cord-010092-uftc8inx 1562 51 HIV HIV NNP cord-010092-uftc8inx 1562 52 infection infection NN cord-010092-uftc8inx 1562 53 ( ( -LRB- cord-010092-uftc8inx 1562 54 MSM MSM NNP cord-010092-uftc8inx 1562 55 , , , cord-010092-uftc8inx 1562 56 HTS HTS NNP cord-010092-uftc8inx 1562 57 , , , cord-010092-uftc8inx 1562 58 others other NNS cord-010092-uftc8inx 1562 59 and and CC cord-010092-uftc8inx 1562 60 unknown unknown JJ cord-010092-uftc8inx 1562 61 ) ) -RRB- cord-010092-uftc8inx 1562 62 . . . cord-010092-uftc8inx 1563 1 Selfreported selfreported JJ cord-010092-uftc8inx 1563 2 data datum NNS cord-010092-uftc8inx 1563 3 were be VBD cord-010092-uftc8inx 1563 4 then then RB cord-010092-uftc8inx 1563 5 compared compare VBN cord-010092-uftc8inx 1563 6 to to IN cord-010092-uftc8inx 1563 7 assortativity assortativity NN cord-010092-uftc8inx 1563 8 - - HYPH cord-010092-uftc8inx 1563 9 enhanced enhance VBN cord-010092-uftc8inx 1563 10 data datum NNS cord-010092-uftc8inx 1563 11 . . . cord-010092-uftc8inx 1564 1 Results result NNS cord-010092-uftc8inx 1564 2 : : : cord-010092-uftc8inx 1565 1 HIV-1 HIV-1 NNP cord-010092-uftc8inx 1565 2 strains strain VBZ cord-010092-uftc8inx 1565 3 from from IN cord-010092-uftc8inx 1565 4 81 81 CD cord-010092-uftc8inx 1565 5 mBDs mbds NN cord-010092-uftc8inx 1565 6 and and CC cord-010092-uftc8inx 1565 7 126 126 CD cord-010092-uftc8inx 1565 8 PCs pc NNS cord-010092-uftc8inx 1565 9 were be VBD cord-010092-uftc8inx 1565 10 linked link VBN cord-010092-uftc8inx 1565 11 into into IN cord-010092-uftc8inx 1565 12 54 54 CD cord-010092-uftc8inx 1565 13 clusters cluster NNS cord-010092-uftc8inx 1565 14 including include VBG cord-010092-uftc8inx 1565 15 at at RB cord-010092-uftc8inx 1565 16 least least RBS cord-010092-uftc8inx 1565 17 one one CD cord-010092-uftc8inx 1565 18 mBD mbd NN cord-010092-uftc8inx 1565 19 . . . cord-010092-uftc8inx 1566 1 PRIMO PRIMO NNP cord-010092-uftc8inx 1566 2 - - HYPH cord-010092-uftc8inx 1566 3 only only JJ cord-010092-uftc8inx 1566 4 clusters cluster NNS cord-010092-uftc8inx 1566 5 were be VBD cord-010092-uftc8inx 1566 6 excluded exclude VBN cord-010092-uftc8inx 1566 7 from from IN cord-010092-uftc8inx 1566 8 the the DT cord-010092-uftc8inx 1566 9 analysis analysis NN cord-010092-uftc8inx 1566 10 . . . cord-010092-uftc8inx 1567 1 Compared compare VBN cord-010092-uftc8inx 1567 2 to to IN cord-010092-uftc8inx 1567 3 mBDs mbds VB cord-010092-uftc8inx 1567 4 who who WP cord-010092-uftc8inx 1567 5 did do VBD cord-010092-uftc8inx 1567 6 not not RB cord-010092-uftc8inx 1567 7 cluster cluster VB cord-010092-uftc8inx 1567 8 , , , cord-010092-uftc8inx 1567 9 those those DT cord-010092-uftc8inx 1567 10 found find VBD cord-010092-uftc8inx 1567 11 linked link VBN cord-010092-uftc8inx 1567 12 to to IN cord-010092-uftc8inx 1567 13 the the DT cord-010092-uftc8inx 1567 14 network network NN cord-010092-uftc8inx 1567 15 were be VBD cord-010092-uftc8inx 1567 16 younger young JJR cord-010092-uftc8inx 1567 17 ( ( -LRB- cord-010092-uftc8inx 1567 18 30 30 CD cord-010092-uftc8inx 1567 19 vs. vs. CC cord-010092-uftc8inx 1567 20 36 36 CD cord-010092-uftc8inx 1567 21 year year NN cord-010092-uftc8inx 1567 22 - - HYPH cord-010092-uftc8inx 1567 23 old old JJ cord-010092-uftc8inx 1567 24 ; ; : cord-010092-uftc8inx 1567 25 P p NN cord-010092-uftc8inx 1567 26 < < XX cord-010092-uftc8inx 1567 27 0.01 0.01 CD cord-010092-uftc8inx 1567 28 ) ) -RRB- cord-010092-uftc8inx 1567 29 and and CC cord-010092-uftc8inx 1567 30 were be VBD cord-010092-uftc8inx 1567 31 more more RBR cord-010092-uftc8inx 1567 32 likely likely JJ cord-010092-uftc8inx 1567 33 to to TO cord-010092-uftc8inx 1567 34 have have VB cord-010092-uftc8inx 1567 35 a a DT cord-010092-uftc8inx 1567 36 recent recent JJ cord-010092-uftc8inx 1567 37 infection infection NN cord-010092-uftc8inx 1567 38 ( ( -LRB- cord-010092-uftc8inx 1567 39 48 48 CD cord-010092-uftc8inx 1567 40 % % NN cord-010092-uftc8inx 1567 41 vs. vs. NN cord-010092-uftc8inx 1567 42 34 34 CD cord-010092-uftc8inx 1567 43 % % NN cord-010092-uftc8inx 1567 44 ; ; : cord-010092-uftc8inx 1567 45 P p NN cord-010092-uftc8inx 1567 46 = = SYM cord-010092-uftc8inx 1567 47 0.03 0.03 CD cord-010092-uftc8inx 1567 48 ) ) -RRB- cord-010092-uftc8inx 1567 49 . . . cord-010092-uftc8inx 1568 1 Assortative Assortative NNP cord-010092-uftc8inx 1568 2 mixing mix VBG cord-010092-uftc8inx 1568 3 indexes index NNS cord-010092-uftc8inx 1568 4 showed show VBD cord-010092-uftc8inx 1568 5 that that IN cord-010092-uftc8inx 1568 6 paired pair VBN cord-010092-uftc8inx 1568 7 individuals individual NNS cord-010092-uftc8inx 1568 8 were be VBD cord-010092-uftc8inx 1568 9 more more RBR cord-010092-uftc8inx 1568 10 likely likely JJ cord-010092-uftc8inx 1568 11 to to TO cord-010092-uftc8inx 1568 12 live live VB cord-010092-uftc8inx 1568 13 in in IN cord-010092-uftc8inx 1568 14 the the DT cord-010092-uftc8inx 1568 15 same same JJ cord-010092-uftc8inx 1568 16 area area NN cord-010092-uftc8inx 1568 17 ( ( -LRB- cord-010092-uftc8inx 1568 18 P p NN cord-010092-uftc8inx 1568 19 < < XX cord-010092-uftc8inx 1568 20 0.001 0.001 CD cord-010092-uftc8inx 1568 21 ) ) -RRB- cord-010092-uftc8inx 1568 22 and and CC cord-010092-uftc8inx 1568 23 to to TO cord-010092-uftc8inx 1568 24 have have VB cord-010092-uftc8inx 1568 25 the the DT cord-010092-uftc8inx 1568 26 same same JJ cord-010092-uftc8inx 1568 27 risk risk NN cord-010092-uftc8inx 1568 28 factor factor NN cord-010092-uftc8inx 1568 29 for for IN cord-010092-uftc8inx 1568 30 HIV HIV NNP cord-010092-uftc8inx 1568 31 infection infection NN cord-010092-uftc8inx 1569 1 ( ( -LRB- cord-010092-uftc8inx 1569 2 P p NN cord-010092-uftc8inx 1569 3 < < XX cord-010092-uftc8inx 1569 4 0.001 0.001 CD cord-010092-uftc8inx 1569 5 ) ) -RRB- cord-010092-uftc8inx 1569 6 compared compare VBD cord-010092-uftc8inx 1569 7 to to IN cord-010092-uftc8inx 1569 8 a a DT cord-010092-uftc8inx 1569 9 random random JJ cord-010092-uftc8inx 1569 10 distribution distribution NN cord-010092-uftc8inx 1569 11 . . . cord-010092-uftc8inx 1570 1 Imputing impute VBG cord-010092-uftc8inx 1570 2 MSM MSM NNP cord-010092-uftc8inx 1570 3 risk risk NN cord-010092-uftc8inx 1570 4 factor factor NN cord-010092-uftc8inx 1570 5 to to IN cord-010092-uftc8inx 1570 6 non non JJ cord-010092-uftc8inx 1570 7 - - JJ cord-010092-uftc8inx 1570 8 MSM msm JJ cord-010092-uftc8inx 1570 9 individuals individual NNS cord-010092-uftc8inx 1570 10 paired pair VBN cord-010092-uftc8inx 1570 11 with with IN cord-010092-uftc8inx 1570 12 MSM MSM NNP cord-010092-uftc8inx 1570 13 changed change VBD cord-010092-uftc8inx 1570 14 the the DT cord-010092-uftc8inx 1570 15 distribution distribution NN cord-010092-uftc8inx 1570 16 of of IN cord-010092-uftc8inx 1570 17 risk risk NN cord-010092-uftc8inx 1570 18 factors factor NNS cord-010092-uftc8inx 1570 19 as as IN cord-010092-uftc8inx 1570 20 follows follow VBZ cord-010092-uftc8inx 1570 21 : : : cord-010092-uftc8inx 1570 22 MSM MSM NNP cord-010092-uftc8inx 1570 23 : : : cord-010092-uftc8inx 1570 24 38 38 CD cord-010092-uftc8inx 1570 25 % % NN cord-010092-uftc8inx 1570 26 vs. vs. IN cord-010092-uftc8inx 1570 27 49 49 CD cord-010092-uftc8inx 1570 28 % % NN cord-010092-uftc8inx 1570 29 , , , cord-010092-uftc8inx 1570 30 HTS HTS NNP cord-010092-uftc8inx 1570 31 : : : cord-010092-uftc8inx 1570 32 24 24 CD cord-010092-uftc8inx 1570 33 % % NN cord-010092-uftc8inx 1570 34 vs. vs. IN cord-010092-uftc8inx 1570 35 21 21 CD cord-010092-uftc8inx 1570 36 % % NN cord-010092-uftc8inx 1570 37 , , , cord-010092-uftc8inx 1570 38 other other JJ cord-010092-uftc8inx 1570 39 : : : cord-010092-uftc8inx 1570 40 7 7 CD cord-010092-uftc8inx 1570 41 % % NN cord-010092-uftc8inx 1570 42 vs. vs. CC cord-010092-uftc8inx 1570 43 6 6 CD cord-010092-uftc8inx 1570 44 % % NN cord-010092-uftc8inx 1570 45 and and CC cord-010092-uftc8inx 1570 46 unknown unknown JJ cord-010092-uftc8inx 1570 47 : : : cord-010092-uftc8inx 1571 1 31 31 CD cord-010092-uftc8inx 1571 2 vs. vs. CC cord-010092-uftc8inx 1571 3 24 24 CD cord-010092-uftc8inx 1571 4 % % NN cord-010092-uftc8inx 1571 5 . . . cord-010092-uftc8inx 1572 1 Summary Summary NNP cord-010092-uftc8inx 1572 2 / / SYM cord-010092-uftc8inx 1572 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 1572 4 : : : cord-010092-uftc8inx 1572 5 After after IN cord-010092-uftc8inx 1572 6 validating validate VBG cord-010092-uftc8inx 1572 7 the the DT cord-010092-uftc8inx 1572 8 assortativity assortativity NN cord-010092-uftc8inx 1572 9 of of IN cord-010092-uftc8inx 1572 10 risk risk NN cord-010092-uftc8inx 1572 11 factors factor NNS cord-010092-uftc8inx 1572 12 between between IN cord-010092-uftc8inx 1572 13 paired pair VBN cord-010092-uftc8inx 1572 14 individuals individual NNS cord-010092-uftc8inx 1572 15 , , , cord-010092-uftc8inx 1572 16 and and CC cord-010092-uftc8inx 1572 17 imputing impute VBG cord-010092-uftc8inx 1572 18 MSM MSM NNP cord-010092-uftc8inx 1572 19 risk risk NN cord-010092-uftc8inx 1572 20 factor factor NN cord-010092-uftc8inx 1572 21 to to IN cord-010092-uftc8inx 1572 22 individuals individual NNS cord-010092-uftc8inx 1572 23 self self NN cord-010092-uftc8inx 1572 24 - - HYPH cord-010092-uftc8inx 1572 25 reported report VBN cord-010092-uftc8inx 1572 26 as as IN cord-010092-uftc8inx 1572 27 non non JJ cord-010092-uftc8inx 1572 28 - - JJ cord-010092-uftc8inx 1572 29 MSM msm JJ cord-010092-uftc8inx 1572 30 ( ( -LRB- cord-010092-uftc8inx 1572 31 including include VBG cord-010092-uftc8inx 1572 32 those those DT cord-010092-uftc8inx 1572 33 with with IN cord-010092-uftc8inx 1572 34 no no DT cord-010092-uftc8inx 1572 35 identified identify VBN cord-010092-uftc8inx 1572 36 risk risk NN cord-010092-uftc8inx 1572 37 factor factor NN cord-010092-uftc8inx 1572 38 ) ) -RRB- cord-010092-uftc8inx 1572 39 , , , cord-010092-uftc8inx 1572 40 up up IN cord-010092-uftc8inx 1572 41 to to TO cord-010092-uftc8inx 1572 42 18 18 CD cord-010092-uftc8inx 1572 43 % % NN cord-010092-uftc8inx 1572 44 ( ( -LRB- cord-010092-uftc8inx 1572 45 31/176 31/176 CD cord-010092-uftc8inx 1572 46 ) ) -RRB- cord-010092-uftc8inx 1572 47 of of IN cord-010092-uftc8inx 1572 48 mBDs mbds NN cord-010092-uftc8inx 1572 49 could could MD cord-010092-uftc8inx 1572 50 be be VB cord-010092-uftc8inx 1572 51 reclassified reclassify VBN cord-010092-uftc8inx 1572 52 as as IN cord-010092-uftc8inx 1572 53 MSM MSM NNP cord-010092-uftc8inx 1572 54 . . . cord-010092-uftc8inx 1573 1 This this DT cord-010092-uftc8inx 1573 2 is be VBZ cord-010092-uftc8inx 1573 3 a a DT cord-010092-uftc8inx 1573 4 worst bad JJS cord-010092-uftc8inx 1573 5 - - HYPH cord-010092-uftc8inx 1573 6 case case NN cord-010092-uftc8inx 1573 7 scenario scenario NN cord-010092-uftc8inx 1573 8 , , , cord-010092-uftc8inx 1573 9 as as IN cord-010092-uftc8inx 1573 10 the the DT cord-010092-uftc8inx 1573 11 network network NN cord-010092-uftc8inx 1573 12 analysis analysis NN cord-010092-uftc8inx 1573 13 does do VBZ cord-010092-uftc8inx 1573 14 not not RB cord-010092-uftc8inx 1573 15 exclude exclude VB cord-010092-uftc8inx 1573 16 the the DT cord-010092-uftc8inx 1573 17 possibility possibility NN cord-010092-uftc8inx 1573 18 of of IN cord-010092-uftc8inx 1573 19 one one CD cord-010092-uftc8inx 1573 20 or or CC cord-010092-uftc8inx 1573 21 several several JJ cord-010092-uftc8inx 1573 22 persons person NNS cord-010092-uftc8inx 1573 23 between between IN cord-010092-uftc8inx 1573 24 two two CD cord-010092-uftc8inx 1573 25 paired pair VBN cord-010092-uftc8inx 1573 26 individuals individual NNS cord-010092-uftc8inx 1573 27 ( ( -LRB- cord-010092-uftc8inx 1573 28 missing miss VBG cord-010092-uftc8inx 1573 29 link link NN cord-010092-uftc8inx 1573 30 ) ) -RRB- cord-010092-uftc8inx 1573 31 . . . cord-010092-uftc8inx 1574 1 Altogether altogether RB cord-010092-uftc8inx 1574 2 , , , cord-010092-uftc8inx 1574 3 these these DT cord-010092-uftc8inx 1574 4 results result NNS cord-010092-uftc8inx 1574 5 could could MD cord-010092-uftc8inx 1574 6 help help VB cord-010092-uftc8inx 1574 7 reevaluate reevaluate VB cord-010092-uftc8inx 1574 8 the the DT cord-010092-uftc8inx 1574 9 HIV HIV NNP cord-010092-uftc8inx 1574 10 residual residual JJ cord-010092-uftc8inx 1574 11 risk risk NN cord-010092-uftc8inx 1574 12 linked link VBN cord-010092-uftc8inx 1574 13 to to IN cord-010092-uftc8inx 1574 14 MSM MSM NNP cord-010092-uftc8inx 1574 15 mBDs mbds NN cord-010092-uftc8inx 1574 16 , , , cord-010092-uftc8inx 1574 17 especially especially RB cord-010092-uftc8inx 1574 18 in in IN cord-010092-uftc8inx 1574 19 the the DT cord-010092-uftc8inx 1574 20 frame frame NN cord-010092-uftc8inx 1574 21 of of IN cord-010092-uftc8inx 1574 22 the the DT cord-010092-uftc8inx 1574 23 evolution evolution NN cord-010092-uftc8inx 1574 24 of of IN cord-010092-uftc8inx 1574 25 blood blood NN cord-010092-uftc8inx 1574 26 donor donor NN cord-010092-uftc8inx 1574 27 deferral deferral NN cord-010092-uftc8inx 1574 28 criteria criterion NNS cord-010092-uftc8inx 1574 29 . . . cord-010092-uftc8inx 1575 1 Background background NN cord-010092-uftc8inx 1575 2 : : : cord-010092-uftc8inx 1576 1 Although although IN cord-010092-uftc8inx 1576 2 most most JJS cord-010092-uftc8inx 1576 3 individuals individual NNS cord-010092-uftc8inx 1576 4 remain remain VBP cord-010092-uftc8inx 1576 5 asymptomatic asymptomatic JJ cord-010092-uftc8inx 1576 6 , , , cord-010092-uftc8inx 1576 7 HTLV HTLV NNP cord-010092-uftc8inx 1576 8 infection infection NN cord-010092-uftc8inx 1576 9 can can MD cord-010092-uftc8inx 1576 10 lead lead VB cord-010092-uftc8inx 1576 11 to to IN cord-010092-uftc8inx 1576 12 adult adult NN cord-010092-uftc8inx 1576 13 T t NN cord-010092-uftc8inx 1576 14 - - HYPH cord-010092-uftc8inx 1576 15 cell cell NN cord-010092-uftc8inx 1576 16 leukaemia leukaemia NN cord-010092-uftc8inx 1576 17 / / SYM cord-010092-uftc8inx 1576 18 lymphoma lymphoma NN cord-010092-uftc8inx 1576 19 ( ( -LRB- cord-010092-uftc8inx 1576 20 ATLL ATLL NNP cord-010092-uftc8inx 1576 21 ) ) -RRB- cord-010092-uftc8inx 1576 22 and and CC cord-010092-uftc8inx 1576 23 HTLV-1 HTLV-1 NNP cord-010092-uftc8inx 1576 24 associated associate VBN cord-010092-uftc8inx 1576 25 myelopathy myelopathy NNP cord-010092-uftc8inx 1576 26 ( ( -LRB- cord-010092-uftc8inx 1576 27 HAM HAM NNP cord-010092-uftc8inx 1576 28 ) ) -RRB- cord-010092-uftc8inx 1576 29 . . . cord-010092-uftc8inx 1577 1 The the DT cord-010092-uftc8inx 1577 2 serious serious JJ cord-010092-uftc8inx 1577 3 nature nature NN cord-010092-uftc8inx 1577 4 of of IN cord-010092-uftc8inx 1577 5 these these DT cord-010092-uftc8inx 1577 6 diseases disease NNS cord-010092-uftc8inx 1577 7 , , , cord-010092-uftc8inx 1577 8 evidence evidence NN cord-010092-uftc8inx 1577 9 of of IN cord-010092-uftc8inx 1577 10 transmission transmission NN cord-010092-uftc8inx 1577 11 via via IN cord-010092-uftc8inx 1577 12 non non JJ cord-010092-uftc8inx 1577 13 - - JJ cord-010092-uftc8inx 1577 14 leucodepleted leucodepleted JJ cord-010092-uftc8inx 1577 15 blood blood NN cord-010092-uftc8inx 1577 16 , , , cord-010092-uftc8inx 1577 17 and and CC cord-010092-uftc8inx 1577 18 concern concern NN cord-010092-uftc8inx 1577 19 about about IN cord-010092-uftc8inx 1577 20 a a DT cord-010092-uftc8inx 1577 21 high high JJ cord-010092-uftc8inx 1577 22 prevalence prevalence NN cord-010092-uftc8inx 1577 23 among among IN cord-010092-uftc8inx 1577 24 donors donor NNS cord-010092-uftc8inx 1577 25 originating originate VBG cord-010092-uftc8inx 1577 26 from from IN cord-010092-uftc8inx 1577 27 endemic endemic JJ cord-010092-uftc8inx 1577 28 areas area NNS cord-010092-uftc8inx 1577 29 led lead VBD cord-010092-uftc8inx 1577 30 to to IN cord-010092-uftc8inx 1577 31 the the DT cord-010092-uftc8inx 1577 32 UK UK NNP cord-010092-uftc8inx 1577 33 blood blood NN cord-010092-uftc8inx 1577 34 services service NNS cord-010092-uftc8inx 1577 35 introducing introduce VBG cord-010092-uftc8inx 1577 36 universal universal JJ cord-010092-uftc8inx 1577 37 blood blood NN cord-010092-uftc8inx 1577 38 donation donation NN cord-010092-uftc8inx 1577 39 screening screening NN cord-010092-uftc8inx 1577 40 in in IN cord-010092-uftc8inx 1577 41 2002 2002 CD cord-010092-uftc8inx 1577 42 . . . cord-010092-uftc8inx 1578 1 Monitoring monitor VBG cord-010092-uftc8inx 1578 2 through through IN cord-010092-uftc8inx 1578 3 routine routine JJ cord-010092-uftc8inx 1578 4 surveillance surveillance NN cord-010092-uftc8inx 1578 5 commenced commence VBD cord-010092-uftc8inx 1578 6 and and CC cord-010092-uftc8inx 1578 7 HTLVinfected htlvinfecte VBN cord-010092-uftc8inx 1578 8 donors donor NNS cord-010092-uftc8inx 1578 9 were be VBD cord-010092-uftc8inx 1578 10 invited invite VBN cord-010092-uftc8inx 1578 11 to to TO cord-010092-uftc8inx 1578 12 participate participate VB cord-010092-uftc8inx 1578 13 in in IN cord-010092-uftc8inx 1578 14 the the DT cord-010092-uftc8inx 1578 15 HTLV HTLV NNP cord-010092-uftc8inx 1578 16 National National NNP cord-010092-uftc8inx 1578 17 Register Register NNP cord-010092-uftc8inx 1578 18 cohort cohort NN cord-010092-uftc8inx 1578 19 study study NN cord-010092-uftc8inx 1578 20 to to TO cord-010092-uftc8inx 1578 21 assess assess VB cord-010092-uftc8inx 1578 22 disease disease NN cord-010092-uftc8inx 1578 23 progression progression NN cord-010092-uftc8inx 1578 24 . . . cord-010092-uftc8inx 1579 1 These these DT cord-010092-uftc8inx 1579 2 data datum NNS cord-010092-uftc8inx 1579 3 together together RB cord-010092-uftc8inx 1579 4 with with IN cord-010092-uftc8inx 1579 5 evidence evidence NN cord-010092-uftc8inx 1579 6 from from IN cord-010092-uftc8inx 1579 7 lookback lookback NNP cord-010092-uftc8inx 1579 8 to to IN cord-010092-uftc8inx 1579 9 previously previously RB cord-010092-uftc8inx 1579 10 untested untested JJ cord-010092-uftc8inx 1579 11 donations donation NNS cord-010092-uftc8inx 1579 12 and and CC cord-010092-uftc8inx 1579 13 cost cost NN cord-010092-uftc8inx 1579 14 - - HYPH cord-010092-uftc8inx 1579 15 effectiveness effectiveness NN cord-010092-uftc8inx 1579 16 analysis analysis NN cord-010092-uftc8inx 1579 17 were be VBD cord-010092-uftc8inx 1579 18 reviewed review VBN cord-010092-uftc8inx 1579 19 by by IN cord-010092-uftc8inx 1579 20 an an DT cord-010092-uftc8inx 1579 21 expert expert NN cord-010092-uftc8inx 1579 22 working work VBG cord-010092-uftc8inx 1579 23 group group NN cord-010092-uftc8inx 1579 24 in in IN cord-010092-uftc8inx 1579 25 2013 2013 CD cord-010092-uftc8inx 1579 26 and and CC cord-010092-uftc8inx 1579 27 2015 2015 CD cord-010092-uftc8inx 1579 28 . . . cord-010092-uftc8inx 1580 1 Aims aim VBZ cord-010092-uftc8inx 1580 2 : : : cord-010092-uftc8inx 1580 3 To to TO cord-010092-uftc8inx 1580 4 describe describe VB cord-010092-uftc8inx 1580 5 the the DT cord-010092-uftc8inx 1580 6 epidemiology epidemiology NN cord-010092-uftc8inx 1580 7 of of IN cord-010092-uftc8inx 1580 8 HTLV HTLV NNP cord-010092-uftc8inx 1580 9 among among IN cord-010092-uftc8inx 1580 10 UK UK NNP cord-010092-uftc8inx 1580 11 blood blood NN cord-010092-uftc8inx 1580 12 donors donor NNS cord-010092-uftc8inx 1580 13 and and CC cord-010092-uftc8inx 1580 14 evidence evidence NN cord-010092-uftc8inx 1580 15 of of IN cord-010092-uftc8inx 1580 16 disease disease NN cord-010092-uftc8inx 1580 17 progression progression NN cord-010092-uftc8inx 1580 18 from from IN cord-010092-uftc8inx 1580 19 long long JJ cord-010092-uftc8inx 1580 20 term term NN cord-010092-uftc8inx 1580 21 follow follow VB cord-010092-uftc8inx 1580 22 up up IN cord-010092-uftc8inx 1580 23 of of IN cord-010092-uftc8inx 1580 24 asymptomatic asymptomatic JJ cord-010092-uftc8inx 1580 25 donors donor NNS cord-010092-uftc8inx 1580 26 . . . cord-010092-uftc8inx 1581 1 Methods method NNS cord-010092-uftc8inx 1581 2 : : : cord-010092-uftc8inx 1581 3 UK UK NNP cord-010092-uftc8inx 1581 4 blood blood NN cord-010092-uftc8inx 1581 5 donations donation NNS cord-010092-uftc8inx 1581 6 screened screen VBN cord-010092-uftc8inx 1581 7 , , , cord-010092-uftc8inx 1581 8 and and CC cord-010092-uftc8inx 1581 9 infected infected JJ cord-010092-uftc8inx 1581 10 donors donor NNS cord-010092-uftc8inx 1581 11 identified identify VBN cord-010092-uftc8inx 1581 12 are be VBP cord-010092-uftc8inx 1581 13 reported report VBN cord-010092-uftc8inx 1581 14 to to IN cord-010092-uftc8inx 1581 15 a a DT cord-010092-uftc8inx 1581 16 national national JJ cord-010092-uftc8inx 1581 17 surveillance surveillance NN cord-010092-uftc8inx 1581 18 scheme scheme NN cord-010092-uftc8inx 1581 19 . . . cord-010092-uftc8inx 1582 1 These these DT cord-010092-uftc8inx 1582 2 donors donor NNS cord-010092-uftc8inx 1582 3 are be VBP cord-010092-uftc8inx 1582 4 contacted contact VBN cord-010092-uftc8inx 1582 5 , , , cord-010092-uftc8inx 1582 6 their -PRON- PRP$ cord-010092-uftc8inx 1582 7 results result NNS cord-010092-uftc8inx 1582 8 explained explain VBD cord-010092-uftc8inx 1582 9 and and CC cord-010092-uftc8inx 1582 10 information information NN cord-010092-uftc8inx 1582 11 about about IN cord-010092-uftc8inx 1582 12 clinical clinical JJ cord-010092-uftc8inx 1582 13 history history NN cord-010092-uftc8inx 1582 14 and and CC cord-010092-uftc8inx 1582 15 possible possible JJ cord-010092-uftc8inx 1582 16 sources source NNS cord-010092-uftc8inx 1582 17 of of IN cord-010092-uftc8inx 1582 18 infection infection NN cord-010092-uftc8inx 1582 19 are be VBP cord-010092-uftc8inx 1582 20 collected collect VBN cord-010092-uftc8inx 1582 21 . . . cord-010092-uftc8inx 1583 1 Where where WRB cord-010092-uftc8inx 1583 2 appropriate appropriate JJ cord-010092-uftc8inx 1583 3 , , , cord-010092-uftc8inx 1583 4 HTLV HTLV NNP cord-010092-uftc8inx 1583 5 - - HYPH cord-010092-uftc8inx 1583 6 infected infect VBN cord-010092-uftc8inx 1583 7 donors donor NNS cord-010092-uftc8inx 1583 8 are be VBP cord-010092-uftc8inx 1583 9 consented consent VBN cord-010092-uftc8inx 1583 10 to to IN cord-010092-uftc8inx 1583 11 the the DT cord-010092-uftc8inx 1583 12 register register NN cord-010092-uftc8inx 1583 13 , , , cord-010092-uftc8inx 1583 14 with with IN cord-010092-uftc8inx 1583 15 participants participant NNS cord-010092-uftc8inx 1583 16 completing complete VBG cord-010092-uftc8inx 1583 17 a a DT cord-010092-uftc8inx 1583 18 baseline baseline JJ cord-010092-uftc8inx 1583 19 questionnaire questionnaire NN cord-010092-uftc8inx 1583 20 about about IN cord-010092-uftc8inx 1583 21 their -PRON- PRP$ cord-010092-uftc8inx 1583 22 health health NN cord-010092-uftc8inx 1583 23 , , , cord-010092-uftc8inx 1583 24 flagged flag VBN cord-010092-uftc8inx 1583 25 in in IN cord-010092-uftc8inx 1583 26 registries registry NNS cord-010092-uftc8inx 1583 27 for for IN cord-010092-uftc8inx 1583 28 cancer cancer NN cord-010092-uftc8inx 1583 29 or or CC cord-010092-uftc8inx 1583 30 death death NN cord-010092-uftc8inx 1583 31 , , , cord-010092-uftc8inx 1583 32 and and CC cord-010092-uftc8inx 1583 33 followed follow VBD cord-010092-uftc8inx 1583 34 up up RP cord-010092-uftc8inx 1583 35 about about IN cord-010092-uftc8inx 1583 36 every every DT cord-010092-uftc8inx 1583 37 2 2 CD cord-010092-uftc8inx 1583 38 - - SYM cord-010092-uftc8inx 1583 39 3 3 CD cord-010092-uftc8inx 1583 40 years year NNS cord-010092-uftc8inx 1583 41 . . . cord-010092-uftc8inx 1584 1 Results result NNS cord-010092-uftc8inx 1584 2 : : : cord-010092-uftc8inx 1585 1 In in IN cord-010092-uftc8inx 1585 2 the the DT cord-010092-uftc8inx 1585 3 UK UK NNP cord-010092-uftc8inx 1585 4 2002 2002 CD cord-010092-uftc8inx 1585 5 -2017 -2017 WP cord-010092-uftc8inx 1585 6 , , , cord-010092-uftc8inx 1585 7 254 254 CD cord-010092-uftc8inx 1585 8 HTLV HTLV NNP cord-010092-uftc8inx 1585 9 - - HYPH cord-010092-uftc8inx 1585 10 infected infect VBN cord-010092-uftc8inx 1585 11 donors donor NNS cord-010092-uftc8inx 1585 12 were be VBD cord-010092-uftc8inx 1585 13 identified identify VBN cord-010092-uftc8inx 1585 14 . . . cord-010092-uftc8inx 1586 1 Prevalence prevalence NN cord-010092-uftc8inx 1586 2 among among IN cord-010092-uftc8inx 1586 3 new new JJ cord-010092-uftc8inx 1586 4 donors donor NNS cord-010092-uftc8inx 1586 5 was be VBD cord-010092-uftc8inx 1586 6 steady steady JJ cord-010092-uftc8inx 1586 7 around around IN cord-010092-uftc8inx 1586 8 5/100 5/100 CD cord-010092-uftc8inx 1586 9 000 000 CD cord-010092-uftc8inx 1586 10 donations donation NNS cord-010092-uftc8inx 1586 11 . . . cord-010092-uftc8inx 1587 1 Prevalence prevalence NN cord-010092-uftc8inx 1587 2 among among IN cord-010092-uftc8inx 1587 3 repeat repeat NN cord-010092-uftc8inx 1587 4 donors donor NNS cord-010092-uftc8inx 1587 5 peaked peak VBD cord-010092-uftc8inx 1587 6 in in IN cord-010092-uftc8inx 1587 7 2002 2002 CD cord-010092-uftc8inx 1587 8 ( ( -LRB- cord-010092-uftc8inx 1587 9 2.7/100 2.7/100 CD cord-010092-uftc8inx 1587 10 000 000 CD cord-010092-uftc8inx 1587 11 donations donation NNS cord-010092-uftc8inx 1587 12 ) ) -RRB- cord-010092-uftc8inx 1587 13 , , , cord-010092-uftc8inx 1587 14 with with IN cord-010092-uftc8inx 1587 15 most most JJS cord-010092-uftc8inx 1587 16 in in IN cord-010092-uftc8inx 1587 17 previously previously RB cord-010092-uftc8inx 1587 18 untested untested JJ cord-010092-uftc8inx 1587 19 . . . cord-010092-uftc8inx 1588 1 From from IN cord-010092-uftc8inx 1588 2 2004 2004 CD cord-010092-uftc8inx 1588 3 to to IN cord-010092-uftc8inx 1588 4 2016 2016 CD cord-010092-uftc8inx 1588 5 , , , cord-010092-uftc8inx 1588 6 prevalence prevalence NN cord-010092-uftc8inx 1588 7 of of IN cord-010092-uftc8inx 1588 8 0.07 0.07 CD cord-010092-uftc8inx 1588 9 per per IN cord-010092-uftc8inx 1588 10 100,000 100,000 CD cord-010092-uftc8inx 1588 11 donations donation NNS cord-010092-uftc8inx 1588 12 ( ( -LRB- cord-010092-uftc8inx 1588 13 average average NN cord-010092-uftc8inx 1588 14 of of IN cord-010092-uftc8inx 1588 15 one one CD cord-010092-uftc8inx 1588 16 positive positive JJ cord-010092-uftc8inx 1588 17 / / SYM cord-010092-uftc8inx 1588 18 year year NN cord-010092-uftc8inx 1588 19 ) ) -RRB- cord-010092-uftc8inx 1588 20 was be VBD cord-010092-uftc8inx 1588 21 recorded record VBN cord-010092-uftc8inx 1588 22 . . . cord-010092-uftc8inx 1589 1 In in IN cord-010092-uftc8inx 1589 2 2017 2017 CD cord-010092-uftc8inx 1589 3 , , , cord-010092-uftc8inx 1589 4 prevalence prevalence NN cord-010092-uftc8inx 1589 5 among among IN cord-010092-uftc8inx 1589 6 new new JJ cord-010092-uftc8inx 1589 7 donors donor NNS cord-010092-uftc8inx 1589 8 increased increase VBD cord-010092-uftc8inx 1589 9 to to IN cord-010092-uftc8inx 1589 10 9.9/100,000 9.9/100,000 CD cord-010092-uftc8inx 1589 11 donations donation NNS cord-010092-uftc8inx 1589 12 ( ( -LRB- cord-010092-uftc8inx 1589 13 17 17 CD cord-010092-uftc8inx 1589 14 positives positive NNS cord-010092-uftc8inx 1589 15 ) ) -RRB- cord-010092-uftc8inx 1589 16 , , , cord-010092-uftc8inx 1589 17 with with IN cord-010092-uftc8inx 1589 18 increased increase VBN cord-010092-uftc8inx 1589 19 numbers number NNS cord-010092-uftc8inx 1589 20 associated associate VBN cord-010092-uftc8inx 1589 21 with with IN cord-010092-uftc8inx 1589 22 Asian asian JJ cord-010092-uftc8inx 1589 23 ethnicity ethnicity NN cord-010092-uftc8inx 1589 24 and and CC cord-010092-uftc8inx 1589 25 coinciding coincide VBG cord-010092-uftc8inx 1589 26 with with IN cord-010092-uftc8inx 1589 27 an an DT cord-010092-uftc8inx 1589 28 increase increase NN cord-010092-uftc8inx 1589 29 in in IN cord-010092-uftc8inx 1589 30 collections collection NNS cord-010092-uftc8inx 1589 31 from from IN cord-010092-uftc8inx 1589 32 BAME BAME NNP cord-010092-uftc8inx 1589 33 groups group NNS cord-010092-uftc8inx 1589 34 . . . cord-010092-uftc8inx 1590 1 Overall overall RB cord-010092-uftc8inx 1590 2 , , , cord-010092-uftc8inx 1590 3 most most JJS cord-010092-uftc8inx 1590 4 were be VBD cord-010092-uftc8inx 1590 5 women woman NNS cord-010092-uftc8inx 1590 6 ( ( -LRB- cord-010092-uftc8inx 1590 7 182/254 182/254 CD cord-010092-uftc8inx 1590 8 , , , cord-010092-uftc8inx 1590 9 72 72 CD cord-010092-uftc8inx 1590 10 % % NN cord-010092-uftc8inx 1590 11 ) ) -RRB- cord-010092-uftc8inx 1590 12 , , , cord-010092-uftc8inx 1590 13 UK UK NNP cord-010092-uftc8inx 1590 14 - - HYPH cord-010092-uftc8inx 1590 15 born bear VBN cord-010092-uftc8inx 1590 16 ( ( -LRB- cord-010092-uftc8inx 1590 17 125/254;49 125/254;49 CD cord-010092-uftc8inx 1590 18 % % NN cord-010092-uftc8inx 1590 19 ) ) -RRB- cord-010092-uftc8inx 1590 20 and and CC cord-010092-uftc8inx 1590 21 HTLV-1 HTLV-1 NNP cord-010092-uftc8inx 1590 22 infections infection NNS cord-010092-uftc8inx 1590 23 ( ( -LRB- cord-010092-uftc8inx 1590 24 228/254;90 228/254;90 CD cord-010092-uftc8inx 1590 25 % % NN cord-010092-uftc8inx 1590 26 ) ) -RRB- cord-010092-uftc8inx 1590 27 . . . cord-010092-uftc8inx 1591 1 Mean mean JJ cord-010092-uftc8inx 1591 2 age age NN cord-010092-uftc8inx 1591 3 was be VBD cord-010092-uftc8inx 1591 4 43 43 CD cord-010092-uftc8inx 1591 5 years year NNS cord-010092-uftc8inx 1591 6 . . . cord-010092-uftc8inx 1592 1 Almost almost RB cord-010092-uftc8inx 1592 2 all all DT cord-010092-uftc8inx 1592 3 positive positive JJ cord-010092-uftc8inx 1592 4 donations donation NNS cord-010092-uftc8inx 1592 5 were be VBD cord-010092-uftc8inx 1592 6 from from IN cord-010092-uftc8inx 1592 7 previously previously RB cord-010092-uftc8inx 1592 8 untested untested JJ cord-010092-uftc8inx 1592 9 donors donor NNS cord-010092-uftc8inx 1592 10 ( ( -LRB- cord-010092-uftc8inx 1592 11 240/254 240/254 CD cord-010092-uftc8inx 1592 12 ) ) -RRB- cord-010092-uftc8inx 1592 13 , , , cord-010092-uftc8inx 1592 14 with with IN cord-010092-uftc8inx 1592 15 seroconversion seroconversion NN cord-010092-uftc8inx 1592 16 within within IN cord-010092-uftc8inx 1592 17 a a DT cord-010092-uftc8inx 1592 18 year year NN cord-010092-uftc8inx 1592 19 of of IN cord-010092-uftc8inx 1592 20 previous previous JJ cord-010092-uftc8inx 1592 21 donation donation NN cord-010092-uftc8inx 1592 22 confirmed confirm VBD cord-010092-uftc8inx 1592 23 for for IN cord-010092-uftc8inx 1592 24 only only RB cord-010092-uftc8inx 1592 25 5 5 CD cord-010092-uftc8inx 1592 26 of of IN cord-010092-uftc8inx 1592 27 the the DT cord-010092-uftc8inx 1592 28 14 14 CD cord-010092-uftc8inx 1592 29 previously previously RB cord-010092-uftc8inx 1592 30 tested test VBN cord-010092-uftc8inx 1592 31 donors donor NNS cord-010092-uftc8inx 1592 32 . . . cord-010092-uftc8inx 1593 1 Typically typically RB cord-010092-uftc8inx 1593 2 , , , cord-010092-uftc8inx 1593 3 infections infection NNS cord-010092-uftc8inx 1593 4 were be VBD cord-010092-uftc8inx 1593 5 associated associate VBN cord-010092-uftc8inx 1593 6 with with IN cord-010092-uftc8inx 1593 7 endemic endemic JJ cord-010092-uftc8inx 1593 8 countries country NNS cord-010092-uftc8inx 1593 9 ( ( -LRB- cord-010092-uftc8inx 1593 10 including include VBG cord-010092-uftc8inx 1593 11 Caribbean caribbean JJ cord-010092-uftc8inx 1593 12 region region NN cord-010092-uftc8inx 1593 13 , , , cord-010092-uftc8inx 1593 14 West West NNP cord-010092-uftc8inx 1593 15 Africa Africa NNP cord-010092-uftc8inx 1593 16 , , , cord-010092-uftc8inx 1593 17 Iran Iran NNP cord-010092-uftc8inx 1593 18 , , , cord-010092-uftc8inx 1593 19 India India NNP cord-010092-uftc8inx 1593 20 and and CC cord-010092-uftc8inx 1593 21 Japan Japan NNP cord-010092-uftc8inx 1593 22 ) ) -RRB- cord-010092-uftc8inx 1593 23 , , , cord-010092-uftc8inx 1593 24 acquired acquire VBD cord-010092-uftc8inx 1593 25 through through IN cord-010092-uftc8inx 1593 26 breast breast NN cord-010092-uftc8inx 1593 27 feeding feeding NN cord-010092-uftc8inx 1593 28 or or CC cord-010092-uftc8inx 1593 29 from from IN cord-010092-uftc8inx 1593 30 their -PRON- PRP$ cord-010092-uftc8inx 1593 31 heterosexual heterosexual JJ cord-010092-uftc8inx 1593 32 partner partner NN cord-010092-uftc8inx 1593 33 originating originate VBG cord-010092-uftc8inx 1593 34 from from IN cord-010092-uftc8inx 1593 35 these these DT cord-010092-uftc8inx 1593 36 countries country NNS cord-010092-uftc8inx 1593 37 . . . cord-010092-uftc8inx 1594 1 Interestingly interestingly RB cord-010092-uftc8inx 1594 2 , , , cord-010092-uftc8inx 1594 3 three three CD cord-010092-uftc8inx 1594 4 were be VBD cord-010092-uftc8inx 1594 5 thought think VBN cord-010092-uftc8inx 1594 6 to to TO cord-010092-uftc8inx 1594 7 have have VB cord-010092-uftc8inx 1594 8 been be VBN cord-010092-uftc8inx 1594 9 infected infect VBN cord-010092-uftc8inx 1594 10 through through IN cord-010092-uftc8inx 1594 11 self self NN cord-010092-uftc8inx 1594 12 - - HYPH cord-010092-uftc8inx 1594 13 flagellation flagellation NN cord-010092-uftc8inx 1594 14 . . . cord-010092-uftc8inx 1595 1 A a DT cord-010092-uftc8inx 1595 2 total total NN cord-010092-uftc8inx 1595 3 of of IN cord-010092-uftc8inx 1595 4 114 114 CD cord-010092-uftc8inx 1595 5 HTLV HTLV NNP cord-010092-uftc8inx 1595 6 - - HYPH cord-010092-uftc8inx 1595 7 positive positive JJ cord-010092-uftc8inx 1595 8 asymptomatic asymptomatic JJ cord-010092-uftc8inx 1595 9 blood blood NN cord-010092-uftc8inx 1595 10 donors donor NNS cord-010092-uftc8inx 1595 11 have have VBP cord-010092-uftc8inx 1595 12 already already RB cord-010092-uftc8inx 1595 13 been be VBN cord-010092-uftc8inx 1595 14 recruited recruit VBN cord-010092-uftc8inx 1595 15 to to IN cord-010092-uftc8inx 1595 16 the the DT cord-010092-uftc8inx 1595 17 HTLV HTLV NNP cord-010092-uftc8inx 1595 18 National National NNP cord-010092-uftc8inx 1595 19 Register Register NNP cord-010092-uftc8inx 1595 20 , , , cord-010092-uftc8inx 1595 21 and and CC cord-010092-uftc8inx 1595 22 during during IN cord-010092-uftc8inx 1595 23 over over IN cord-010092-uftc8inx 1595 24 800-person 800-person CD cord-010092-uftc8inx 1595 25 years year NNS cord-010092-uftc8inx 1595 26 follow follow NN cord-010092-uftc8inx 1595 27 - - HYPH cord-010092-uftc8inx 1595 28 up up NN cord-010092-uftc8inx 1595 29 , , , cord-010092-uftc8inx 1595 30 none none NN cord-010092-uftc8inx 1595 31 had have VBD cord-010092-uftc8inx 1595 32 developed develop VBN cord-010092-uftc8inx 1595 33 ATLL ATLL NNP cord-010092-uftc8inx 1595 34 or or CC cord-010092-uftc8inx 1595 35 HAM HAM NNP cord-010092-uftc8inx 1595 36 . . . cord-010092-uftc8inx 1596 1 Summary Summary NNP cord-010092-uftc8inx 1596 2 / / SYM cord-010092-uftc8inx 1596 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 1596 4 : : : cord-010092-uftc8inx 1597 1 Over over IN cord-010092-uftc8inx 1597 2 16 16 CD cord-010092-uftc8inx 1597 3 years year NNS cord-010092-uftc8inx 1597 4 of of IN cord-010092-uftc8inx 1597 5 testing testing NN cord-010092-uftc8inx 1597 6 , , , cord-010092-uftc8inx 1597 7 few few JJ cord-010092-uftc8inx 1597 8 seroconverters seroconverter NNS cord-010092-uftc8inx 1597 9 were be VBD cord-010092-uftc8inx 1597 10 identified identify VBN cord-010092-uftc8inx 1597 11 , , , cord-010092-uftc8inx 1597 12 suggesting suggest VBG cord-010092-uftc8inx 1597 13 very very RB cord-010092-uftc8inx 1597 14 little little JJ cord-010092-uftc8inx 1597 15 ongoing ongoing JJ cord-010092-uftc8inx 1597 16 transmission transmission NN cord-010092-uftc8inx 1597 17 among among IN cord-010092-uftc8inx 1597 18 UK UK NNP cord-010092-uftc8inx 1597 19 blood blood NN cord-010092-uftc8inx 1597 20 donors donor NNS cord-010092-uftc8inx 1597 21 . . . cord-010092-uftc8inx 1598 1 The the DT cord-010092-uftc8inx 1598 2 lack lack NN cord-010092-uftc8inx 1598 3 of of IN cord-010092-uftc8inx 1598 4 disease disease NN cord-010092-uftc8inx 1598 5 among among IN cord-010092-uftc8inx 1598 6 the the DT cord-010092-uftc8inx 1598 7 cohort cohort NN cord-010092-uftc8inx 1598 8 study study NN cord-010092-uftc8inx 1598 9 was be VBD cord-010092-uftc8inx 1598 10 also also RB cord-010092-uftc8inx 1598 11 reassuring reassure VBG cord-010092-uftc8inx 1598 12 , , , cord-010092-uftc8inx 1598 13 although although IN cord-010092-uftc8inx 1598 14 it -PRON- PRP cord-010092-uftc8inx 1598 15 is be VBZ cord-010092-uftc8inx 1598 16 likely likely JJ cord-010092-uftc8inx 1598 17 too too RB cord-010092-uftc8inx 1598 18 early early JJ cord-010092-uftc8inx 1598 19 to to TO cord-010092-uftc8inx 1598 20 detect detect VB cord-010092-uftc8inx 1598 21 associated associated JJ cord-010092-uftc8inx 1598 22 symptoms symptom NNS cord-010092-uftc8inx 1598 23 of of IN cord-010092-uftc8inx 1598 24 a a DT cord-010092-uftc8inx 1598 25 slow slow JJ cord-010092-uftc8inx 1598 26 progressing progress VBG cord-010092-uftc8inx 1598 27 disease disease NN cord-010092-uftc8inx 1598 28 . . . cord-010092-uftc8inx 1599 1 Recruitment recruitment NN cord-010092-uftc8inx 1599 2 to to IN cord-010092-uftc8inx 1599 3 this this DT cord-010092-uftc8inx 1599 4 unique unique JJ cord-010092-uftc8inx 1599 5 dataset dataset NN cord-010092-uftc8inx 1599 6 continues continue VBZ cord-010092-uftc8inx 1599 7 , , , cord-010092-uftc8inx 1599 8 also also RB cord-010092-uftc8inx 1599 9 outside outside RB cord-010092-uftc8inx 1599 10 of of IN cord-010092-uftc8inx 1599 11 the the DT cord-010092-uftc8inx 1599 12 blood blood NN cord-010092-uftc8inx 1599 13 donation donation NN cord-010092-uftc8inx 1599 14 setting setting NN cord-010092-uftc8inx 1599 15 . . . cord-010092-uftc8inx 1600 1 As as IN cord-010092-uftc8inx 1600 2 a a DT cord-010092-uftc8inx 1600 3 result result NN cord-010092-uftc8inx 1600 4 of of IN cord-010092-uftc8inx 1600 5 these these DT cord-010092-uftc8inx 1600 6 surveillance surveillance NN cord-010092-uftc8inx 1600 7 data datum NNS cord-010092-uftc8inx 1600 8 , , , cord-010092-uftc8inx 1600 9 evidence evidence NN cord-010092-uftc8inx 1600 10 from from IN cord-010092-uftc8inx 1600 11 lookback lookback NNP cord-010092-uftc8inx 1600 12 , , , cord-010092-uftc8inx 1600 13 and and CC cord-010092-uftc8inx 1600 14 cost cost NN cord-010092-uftc8inx 1600 15 - - HYPH cord-010092-uftc8inx 1600 16 effective effective JJ cord-010092-uftc8inx 1600 17 analysis analysis NN cord-010092-uftc8inx 1600 18 , , , cord-010092-uftc8inx 1600 19 in in IN cord-010092-uftc8inx 1600 20 2017 2017 CD cord-010092-uftc8inx 1600 21 NHSBT NHSBT NNP cord-010092-uftc8inx 1600 22 ceased cease VBD cord-010092-uftc8inx 1600 23 to to TO cord-010092-uftc8inx 1600 24 test test VB cord-010092-uftc8inx 1600 25 donations donation NNS cord-010092-uftc8inx 1600 26 from from IN cord-010092-uftc8inx 1600 27 previously previously RB cord-010092-uftc8inx 1600 28 tested test VBN cord-010092-uftc8inx 1600 29 donors donor NNS cord-010092-uftc8inx 1600 30 unless unless IN cord-010092-uftc8inx 1600 31 the the DT cord-010092-uftc8inx 1600 32 donation donation NN cord-010092-uftc8inx 1600 33 was be VBD cord-010092-uftc8inx 1600 34 being be VBG cord-010092-uftc8inx 1600 35 used use VBN cord-010092-uftc8inx 1600 36 to to TO cord-010092-uftc8inx 1600 37 manufacture manufacture VB cord-010092-uftc8inx 1600 38 a a DT cord-010092-uftc8inx 1600 39 non non JJ cord-010092-uftc8inx 1600 40 - - JJ cord-010092-uftc8inx 1600 41 leucodepleted leucodepleted JJ cord-010092-uftc8inx 1600 42 component component NN cord-010092-uftc8inx 1600 43 . . . cord-010092-uftc8inx 1601 1 Finland Finland NNP cord-010092-uftc8inx 1601 2 lies lie VBZ cord-010092-uftc8inx 1601 3 in in IN cord-010092-uftc8inx 1601 4 Northern Northern NNP cord-010092-uftc8inx 1601 5 Europe Europe NNP cord-010092-uftc8inx 1601 6 between between IN cord-010092-uftc8inx 1601 7 the the DT cord-010092-uftc8inx 1601 8 60 60 CD cord-010092-uftc8inx 1601 9 ° ° NNS cord-010092-uftc8inx 1601 10 and and CC cord-010092-uftc8inx 1601 11 70 70 CD cord-010092-uftc8inx 1601 12 ° ° NN cord-010092-uftc8inx 1601 13 N n CD cord-010092-uftc8inx 1601 14 latitude latitude NN cord-010092-uftc8inx 1601 15 . . . cord-010092-uftc8inx 1602 1 The the DT cord-010092-uftc8inx 1602 2 length length NN cord-010092-uftc8inx 1602 3 of of IN cord-010092-uftc8inx 1602 4 the the DT cord-010092-uftc8inx 1602 5 country country NN cord-010092-uftc8inx 1602 6 is be VBZ cord-010092-uftc8inx 1602 7 1150 1150 CD cord-010092-uftc8inx 1602 8 km km NN cord-010092-uftc8inx 1602 9 and and CC cord-010092-uftc8inx 1602 10 width width NN cord-010092-uftc8inx 1602 11 550 550 CD cord-010092-uftc8inx 1602 12 km km NNS cord-010092-uftc8inx 1602 13 . . . cord-010092-uftc8inx 1603 1 By by IN cord-010092-uftc8inx 1603 2 surface surface NN cord-010092-uftc8inx 1603 3 area area NN cord-010092-uftc8inx 1603 4 it -PRON- PRP cord-010092-uftc8inx 1603 5 is be VBZ cord-010092-uftc8inx 1603 6 the the DT cord-010092-uftc8inx 1603 7 fifth fifth RB cord-010092-uftc8inx 1603 8 largest large JJS cord-010092-uftc8inx 1603 9 country country NN cord-010092-uftc8inx 1603 10 in in IN cord-010092-uftc8inx 1603 11 EU EU NNP cord-010092-uftc8inx 1603 12 . . . cord-010092-uftc8inx 1604 1 The the DT cord-010092-uftc8inx 1604 2 population population NN cord-010092-uftc8inx 1604 3 of of IN cord-010092-uftc8inx 1604 4 the the DT cord-010092-uftc8inx 1604 5 country country NN cord-010092-uftc8inx 1604 6 is be VBZ cord-010092-uftc8inx 1604 7 5.5 5.5 CD cord-010092-uftc8inx 1604 8 million million CD cord-010092-uftc8inx 1604 9 resulting result VBG cord-010092-uftc8inx 1604 10 in in IN cord-010092-uftc8inx 1604 11 the the DT cord-010092-uftc8inx 1604 12 lowest low JJS cord-010092-uftc8inx 1604 13 population population NN cord-010092-uftc8inx 1604 14 density density NN cord-010092-uftc8inx 1604 15 in in IN cord-010092-uftc8inx 1604 16 EU EU NNP cord-010092-uftc8inx 1604 17 ( ( -LRB- cord-010092-uftc8inx 1604 18 15.8 15.8 CD cord-010092-uftc8inx 1604 19 inhabitants inhabitant NNS cord-010092-uftc8inx 1604 20 / / SYM cord-010092-uftc8inx 1604 21 km3 km3 NNP cord-010092-uftc8inx 1604 22 ) ) -RRB- cord-010092-uftc8inx 1604 23 . . . cord-010092-uftc8inx 1605 1 The the DT cord-010092-uftc8inx 1605 2 whole whole JJ cord-010092-uftc8inx 1605 3 country country NN cord-010092-uftc8inx 1605 4 is be VBZ cord-010092-uftc8inx 1605 5 inhabited inhabit VBN cord-010092-uftc8inx 1605 6 , , , cord-010092-uftc8inx 1605 7 although although IN cord-010092-uftc8inx 1605 8 most most JJS cord-010092-uftc8inx 1605 9 of of IN cord-010092-uftc8inx 1605 10 the the DT cord-010092-uftc8inx 1605 11 population population NN cord-010092-uftc8inx 1605 12 is be VBZ cord-010092-uftc8inx 1605 13 packed pack VBN cord-010092-uftc8inx 1605 14 in in IN cord-010092-uftc8inx 1605 15 the the DT cord-010092-uftc8inx 1605 16 south south NN cord-010092-uftc8inx 1605 17 . . . cord-010092-uftc8inx 1606 1 The the DT cord-010092-uftc8inx 1606 2 climate climate NN cord-010092-uftc8inx 1606 3 of of IN cord-010092-uftc8inx 1606 4 Finland Finland NNP cord-010092-uftc8inx 1606 5 is be VBZ cord-010092-uftc8inx 1606 6 influenced influence VBN cord-010092-uftc8inx 1606 7 mainly mainly RB cord-010092-uftc8inx 1606 8 by by IN cord-010092-uftc8inx 1606 9 its -PRON- PRP$ cord-010092-uftc8inx 1606 10 latitude latitude NN cord-010092-uftc8inx 1606 11 , , , cord-010092-uftc8inx 1606 12 but but CC cord-010092-uftc8inx 1606 13 the the DT cord-010092-uftc8inx 1606 14 warm warm JJ cord-010092-uftc8inx 1606 15 waters water NNS cord-010092-uftc8inx 1606 16 of of IN cord-010092-uftc8inx 1606 17 the the DT cord-010092-uftc8inx 1606 18 Gulf Gulf NNP cord-010092-uftc8inx 1606 19 Stream Stream NNP cord-010092-uftc8inx 1606 20 and and CC cord-010092-uftc8inx 1606 21 the the DT cord-010092-uftc8inx 1606 22 North North NNP cord-010092-uftc8inx 1606 23 Atlantic Atlantic NNP cord-010092-uftc8inx 1606 24 Drift Drift NNP cord-010092-uftc8inx 1606 25 Current Current NNP cord-010092-uftc8inx 1606 26 also also RB cord-010092-uftc8inx 1606 27 play play VBP cord-010092-uftc8inx 1606 28 a a DT cord-010092-uftc8inx 1606 29 role role NN cord-010092-uftc8inx 1606 30 . . . cord-010092-uftc8inx 1607 1 Due due IN cord-010092-uftc8inx 1607 2 to to IN cord-010092-uftc8inx 1607 3 Finland Finland NNP cord-010092-uftc8inx 1607 4 's 's POS cord-010092-uftc8inx 1607 5 northern northern JJ cord-010092-uftc8inx 1607 6 location location NN cord-010092-uftc8inx 1607 7 , , , cord-010092-uftc8inx 1607 8 winter winter NN cord-010092-uftc8inx 1607 9 is be VBZ cord-010092-uftc8inx 1607 10 the the DT cord-010092-uftc8inx 1607 11 longest long JJS cord-010092-uftc8inx 1607 12 season season NN cord-010092-uftc8inx 1607 13 . . . cord-010092-uftc8inx 1608 1 The the DT cord-010092-uftc8inx 1608 2 southern southern JJ cord-010092-uftc8inx 1608 3 portions portion NNS cord-010092-uftc8inx 1608 4 of of IN cord-010092-uftc8inx 1608 5 the the DT cord-010092-uftc8inx 1608 6 country country NN cord-010092-uftc8inx 1608 7 are be VBP cord-010092-uftc8inx 1608 8 snow snow NN cord-010092-uftc8inx 1608 9 - - HYPH cord-010092-uftc8inx 1608 10 covered cover VBN cord-010092-uftc8inx 1608 11 about about RB cord-010092-uftc8inx 1608 12 three three CD cord-010092-uftc8inx 1608 13 or or CC cord-010092-uftc8inx 1608 14 four four CD cord-010092-uftc8inx 1608 15 months month NNS cord-010092-uftc8inx 1608 16 of of IN cord-010092-uftc8inx 1608 17 the the DT cord-010092-uftc8inx 1608 18 year year NN cord-010092-uftc8inx 1608 19 , , , cord-010092-uftc8inx 1608 20 and and CC cord-010092-uftc8inx 1608 21 the the DT cord-010092-uftc8inx 1608 22 northern northern JJ cord-010092-uftc8inx 1608 23 regions region NNS cord-010092-uftc8inx 1608 24 for for IN cord-010092-uftc8inx 1608 25 about about RB cord-010092-uftc8inx 1608 26 seven seven CD cord-010092-uftc8inx 1608 27 months month NNS cord-010092-uftc8inx 1608 28 . . . cord-010092-uftc8inx 1609 1 Long long JJ cord-010092-uftc8inx 1609 2 distances distance NNS cord-010092-uftc8inx 1609 3 , , , cord-010092-uftc8inx 1609 4 low low JJ cord-010092-uftc8inx 1609 5 population population NN cord-010092-uftc8inx 1609 6 density density NN cord-010092-uftc8inx 1609 7 and and CC cord-010092-uftc8inx 1609 8 the the DT cord-010092-uftc8inx 1609 9 extreme extreme JJ cord-010092-uftc8inx 1609 10 climate climate NN cord-010092-uftc8inx 1609 11 give give VBP cord-010092-uftc8inx 1609 12 logistical logistical JJ cord-010092-uftc8inx 1609 13 challenges challenge NNS cord-010092-uftc8inx 1609 14 . . . cord-010092-uftc8inx 1610 1 It -PRON- PRP cord-010092-uftc8inx 1610 2 is be VBZ cord-010092-uftc8inx 1610 3 estimated estimate VBN cord-010092-uftc8inx 1610 4 that that IN cord-010092-uftc8inx 1610 5 these these DT cord-010092-uftc8inx 1610 6 logistical logistical JJ cord-010092-uftc8inx 1610 7 costs cost NNS cord-010092-uftc8inx 1610 8 can can MD cord-010092-uftc8inx 1610 9 be be VB cord-010092-uftc8inx 1610 10 as as RB cord-010092-uftc8inx 1610 11 much much JJ cord-010092-uftc8inx 1610 12 as as IN cord-010092-uftc8inx 1610 13 10 10 CD cord-010092-uftc8inx 1610 14 - - SYM cord-010092-uftc8inx 1610 15 20 20 CD cord-010092-uftc8inx 1610 16 % % NN cord-010092-uftc8inx 1610 17 of of IN cord-010092-uftc8inx 1610 18 GDP GDP NNP cord-010092-uftc8inx 1610 19 in in IN cord-010092-uftc8inx 1610 20 Finland Finland NNP cord-010092-uftc8inx 1610 21 . . . cord-010092-uftc8inx 1611 1 The the DT cord-010092-uftc8inx 1611 2 Finnish finnish JJ cord-010092-uftc8inx 1611 3 Red Red NNP cord-010092-uftc8inx 1611 4 Cross Cross NNP cord-010092-uftc8inx 1611 5 Blood Blood NNP cord-010092-uftc8inx 1611 6 Service Service NNP cord-010092-uftc8inx 1611 7 ( ( -LRB- cord-010092-uftc8inx 1611 8 FRC FRC NNP cord-010092-uftc8inx 1611 9 BS BS NNP cord-010092-uftc8inx 1611 10 ) ) -RRB- cord-010092-uftc8inx 1611 11 has have VBZ cord-010092-uftc8inx 1611 12 been be VBN cord-010092-uftc8inx 1611 13 the the DT cord-010092-uftc8inx 1611 14 nationwide nationwide JJ cord-010092-uftc8inx 1611 15 blood blood NN cord-010092-uftc8inx 1611 16 service service NN cord-010092-uftc8inx 1611 17 provider provider NN cord-010092-uftc8inx 1611 18 in in IN cord-010092-uftc8inx 1611 19 Finland Finland NNP cord-010092-uftc8inx 1611 20 since since IN cord-010092-uftc8inx 1611 21 1948 1948 CD cord-010092-uftc8inx 1611 22 . . . cord-010092-uftc8inx 1612 1 FRC FRC NNP cord-010092-uftc8inx 1612 2 BS BS NNP cord-010092-uftc8inx 1612 3 collects collect VBZ cord-010092-uftc8inx 1612 4 annually annually RB cord-010092-uftc8inx 1612 5 about about RB cord-010092-uftc8inx 1612 6 200 200 CD cord-010092-uftc8inx 1612 7 000 000 CD cord-010092-uftc8inx 1612 8 whole whole JJ cord-010092-uftc8inx 1612 9 blood blood NN cord-010092-uftc8inx 1612 10 units unit NNS cord-010092-uftc8inx 1612 11 of of IN cord-010092-uftc8inx 1612 12 which which WDT cord-010092-uftc8inx 1612 13 50 50 CD cord-010092-uftc8inx 1612 14 % % NN cord-010092-uftc8inx 1612 15 are be VBP cord-010092-uftc8inx 1612 16 collected collect VBN cord-010092-uftc8inx 1612 17 in in IN cord-010092-uftc8inx 1612 18 10 10 CD cord-010092-uftc8inx 1612 19 fixed fix VBN cord-010092-uftc8inx 1612 20 sites site NNS cord-010092-uftc8inx 1612 21 and and CC cord-010092-uftc8inx 1612 22 50 50 CD cord-010092-uftc8inx 1612 23 % % NN cord-010092-uftc8inx 1612 24 in in IN cord-010092-uftc8inx 1612 25 mobile mobile JJ cord-010092-uftc8inx 1612 26 sessions session NNS cord-010092-uftc8inx 1612 27 around around IN cord-010092-uftc8inx 1612 28 the the DT cord-010092-uftc8inx 1612 29 country country NN cord-010092-uftc8inx 1612 30 . . . cord-010092-uftc8inx 1613 1 Central central JJ cord-010092-uftc8inx 1613 2 activities activity NNS cord-010092-uftc8inx 1613 3 ( ( -LRB- cord-010092-uftc8inx 1613 4 donor donor NN cord-010092-uftc8inx 1613 5 recruitment recruitment NN cord-010092-uftc8inx 1613 6 , , , cord-010092-uftc8inx 1613 7 medical medical JJ cord-010092-uftc8inx 1613 8 support support NN cord-010092-uftc8inx 1613 9 , , , cord-010092-uftc8inx 1613 10 production production NN cord-010092-uftc8inx 1613 11 , , , cord-010092-uftc8inx 1613 12 testing testing NN cord-010092-uftc8inx 1613 13 , , , cord-010092-uftc8inx 1613 14 supply supply NN cord-010092-uftc8inx 1613 15 chain chain NN cord-010092-uftc8inx 1613 16 management management NN cord-010092-uftc8inx 1613 17 , , , cord-010092-uftc8inx 1613 18 digital digital NNP cord-010092-uftc8inx 1613 19 services service NNS cord-010092-uftc8inx 1613 20 and and CC cord-010092-uftc8inx 1613 21 administration administration NN cord-010092-uftc8inx 1613 22 ) ) -RRB- cord-010092-uftc8inx 1613 23 are be VBP cord-010092-uftc8inx 1613 24 located locate VBN cord-010092-uftc8inx 1613 25 in in IN cord-010092-uftc8inx 1613 26 Helsinki Helsinki NNP cord-010092-uftc8inx 1613 27 . . . cord-010092-uftc8inx 1614 1 Management management NN cord-010092-uftc8inx 1614 2 of of IN cord-010092-uftc8inx 1614 3 transfusion transfusion NN cord-010092-uftc8inx 1614 4 is be VBZ cord-010092-uftc8inx 1614 5 highly highly RB cord-010092-uftc8inx 1614 6 dependent dependent JJ cord-010092-uftc8inx 1614 7 on on IN cord-010092-uftc8inx 1614 8 the the DT cord-010092-uftc8inx 1614 9 logistical logistical JJ cord-010092-uftc8inx 1614 10 arrangements arrangement NNS cord-010092-uftc8inx 1614 11 from from IN cord-010092-uftc8inx 1614 12 blood blood NN cord-010092-uftc8inx 1614 13 donation donation NN cord-010092-uftc8inx 1614 14 sites site NNS cord-010092-uftc8inx 1614 15 to to IN cord-010092-uftc8inx 1614 16 the the DT cord-010092-uftc8inx 1614 17 central central JJ cord-010092-uftc8inx 1614 18 facilities facility NNS cord-010092-uftc8inx 1614 19 and and CC cord-010092-uftc8inx 1614 20 from from IN cord-010092-uftc8inx 1614 21 the the DT cord-010092-uftc8inx 1614 22 central central JJ cord-010092-uftc8inx 1614 23 inventory inventory NN cord-010092-uftc8inx 1614 24 to to IN cord-010092-uftc8inx 1614 25 the the DT cord-010092-uftc8inx 1614 26 hospitals hospital NNS cord-010092-uftc8inx 1614 27 . . . cord-010092-uftc8inx 1615 1 The the DT cord-010092-uftc8inx 1615 2 logistics logistics NN cord-010092-uftc8inx 1615 3 is be VBZ cord-010092-uftc8inx 1615 4 outsourced outsource VBN cord-010092-uftc8inx 1615 5 to to IN cord-010092-uftc8inx 1615 6 three three CD cord-010092-uftc8inx 1615 7 major major JJ cord-010092-uftc8inx 1615 8 partners partner NNS cord-010092-uftc8inx 1615 9 all all DT cord-010092-uftc8inx 1615 10 of of IN cord-010092-uftc8inx 1615 11 whom whom WP cord-010092-uftc8inx 1615 12 have have VBP cord-010092-uftc8inx 1615 13 their -PRON- PRP$ cord-010092-uftc8inx 1615 14 roots root NNS cord-010092-uftc8inx 1615 15 in in IN cord-010092-uftc8inx 1615 16 nationwide nationwide JJ cord-010092-uftc8inx 1615 17 public public JJ cord-010092-uftc8inx 1615 18 transportation transportation NN cord-010092-uftc8inx 1615 19 and and CC cord-010092-uftc8inx 1615 20 logistics logistic NNS cord-010092-uftc8inx 1615 21 services service NNS cord-010092-uftc8inx 1615 22 . . . cord-010092-uftc8inx 1616 1 Posti Posti NNP cord-010092-uftc8inx 1616 2 Ltd Ltd NNP cord-010092-uftc8inx 1616 3 is be VBZ cord-010092-uftc8inx 1616 4 a a DT cord-010092-uftc8inx 1616 5 state state NN cord-010092-uftc8inx 1616 6 owned own VBN cord-010092-uftc8inx 1616 7 company company NN cord-010092-uftc8inx 1616 8 having have VBG cord-010092-uftc8inx 1616 9 its -PRON- PRP$ cord-010092-uftc8inx 1616 10 roots root NNS cord-010092-uftc8inx 1616 11 in in IN cord-010092-uftc8inx 1616 12 the the DT cord-010092-uftc8inx 1616 13 national national JJ cord-010092-uftc8inx 1616 14 postal postal NNP cord-010092-uftc8inx 1616 15 and and CC cord-010092-uftc8inx 1616 16 telecom telecom NN cord-010092-uftc8inx 1616 17 office office NN cord-010092-uftc8inx 1616 18 . . . cord-010092-uftc8inx 1617 1 Today today NN cord-010092-uftc8inx 1617 2 it -PRON- PRP cord-010092-uftc8inx 1617 3 is be VBZ cord-010092-uftc8inx 1617 4 the the DT cord-010092-uftc8inx 1617 5 leading lead VBG cord-010092-uftc8inx 1617 6 postal postal JJ cord-010092-uftc8inx 1617 7 and and CC cord-010092-uftc8inx 1617 8 logistics logistics NN cord-010092-uftc8inx 1617 9 service service NN cord-010092-uftc8inx 1617 10 company company NN cord-010092-uftc8inx 1617 11 having have VBG cord-010092-uftc8inx 1617 12 the the DT cord-010092-uftc8inx 1617 13 widest wide JJS cord-010092-uftc8inx 1617 14 network network NN cord-010092-uftc8inx 1617 15 coverage coverage NN cord-010092-uftc8inx 1617 16 in in IN cord-010092-uftc8inx 1617 17 Finland Finland NNP cord-010092-uftc8inx 1617 18 . . . cord-010092-uftc8inx 1618 1 Blood blood NN cord-010092-uftc8inx 1618 2 units unit NNS cord-010092-uftc8inx 1618 3 collected collect VBN cord-010092-uftc8inx 1618 4 at at IN cord-010092-uftc8inx 1618 5 different different JJ cord-010092-uftc8inx 1618 6 fixed fix VBN cord-010092-uftc8inx 1618 7 sites site NNS cord-010092-uftc8inx 1618 8 and and CC cord-010092-uftc8inx 1618 9 mobile mobile JJ cord-010092-uftc8inx 1618 10 sessions session NNS cord-010092-uftc8inx 1618 11 are be VBP cord-010092-uftc8inx 1618 12 transported transport VBN cord-010092-uftc8inx 1618 13 overnight overnight RB cord-010092-uftc8inx 1618 14 by by IN cord-010092-uftc8inx 1618 15 Posti Posti NNP cord-010092-uftc8inx 1618 16 Ltd Ltd NNP cord-010092-uftc8inx 1618 17 to to IN cord-010092-uftc8inx 1618 18 the the DT cord-010092-uftc8inx 1618 19 FRC FRC NNP cord-010092-uftc8inx 1618 20 BS BS NNP cord-010092-uftc8inx 1618 21 central central JJ cord-010092-uftc8inx 1618 22 facilities facility NNS cord-010092-uftc8inx 1618 23 by by IN cord-010092-uftc8inx 1618 24 8 8 CD cord-010092-uftc8inx 1618 25 am am NN cord-010092-uftc8inx 1618 26 on on IN cord-010092-uftc8inx 1618 27 the the DT cord-010092-uftc8inx 1618 28 day day NN cord-010092-uftc8inx 1618 29 following follow VBG cord-010092-uftc8inx 1618 30 the the DT cord-010092-uftc8inx 1618 31 blood blood NN cord-010092-uftc8inx 1618 32 donation donation NN cord-010092-uftc8inx 1618 33 . . . cord-010092-uftc8inx 1619 1 Posti Posti NNP cord-010092-uftc8inx 1619 2 Ltd Ltd NNP cord-010092-uftc8inx 1619 3 is be VBZ cord-010092-uftc8inx 1619 4 also also RB cord-010092-uftc8inx 1619 5 used use VBN cord-010092-uftc8inx 1619 6 for for IN cord-010092-uftc8inx 1619 7 the the DT cord-010092-uftc8inx 1619 8 regular regular JJ cord-010092-uftc8inx 1619 9 deliveries delivery NNS cord-010092-uftc8inx 1619 10 of of IN cord-010092-uftc8inx 1619 11 blood blood NN cord-010092-uftc8inx 1619 12 products product NNS cord-010092-uftc8inx 1619 13 to to IN cord-010092-uftc8inx 1619 14 the the DT cord-010092-uftc8inx 1619 15 hospitals hospital NNS cord-010092-uftc8inx 1619 16 . . . cord-010092-uftc8inx 1620 1 The the DT cord-010092-uftc8inx 1620 2 other other JJ cord-010092-uftc8inx 1620 3 important important JJ cord-010092-uftc8inx 1620 4 partner partner NN cord-010092-uftc8inx 1620 5 is be VBZ cord-010092-uftc8inx 1620 6 Matkahuolto Matkahuolto NNP cord-010092-uftc8inx 1620 7 Ltd Ltd NNP cord-010092-uftc8inx 1620 8 , , , cord-010092-uftc8inx 1620 9 which which WDT cord-010092-uftc8inx 1620 10 was be VBD cord-010092-uftc8inx 1620 11 founded found VBN cord-010092-uftc8inx 1620 12 in in IN cord-010092-uftc8inx 1620 13 the the DT cord-010092-uftc8inx 1620 14 1930s 1930 NNS cord-010092-uftc8inx 1620 15 to to TO cord-010092-uftc8inx 1620 16 maintain maintain VB cord-010092-uftc8inx 1620 17 bus bus NN cord-010092-uftc8inx 1620 18 stations station NNS cord-010092-uftc8inx 1620 19 and and CC cord-010092-uftc8inx 1620 20 to to TO cord-010092-uftc8inx 1620 21 serve serve VB cord-010092-uftc8inx 1620 22 as as IN cord-010092-uftc8inx 1620 23 a a DT cord-010092-uftc8inx 1620 24 common common JJ cord-010092-uftc8inx 1620 25 marketing marketing NN cord-010092-uftc8inx 1620 26 company company NN cord-010092-uftc8inx 1620 27 for for IN cord-010092-uftc8inx 1620 28 the the DT cord-010092-uftc8inx 1620 29 bus bus NN cord-010092-uftc8inx 1620 30 and and CC cord-010092-uftc8inx 1620 31 coach coach NN cord-010092-uftc8inx 1620 32 services service NNS cord-010092-uftc8inx 1620 33 in in IN cord-010092-uftc8inx 1620 34 Finland Finland NNP cord-010092-uftc8inx 1620 35 . . . cord-010092-uftc8inx 1621 1 It -PRON- PRP cord-010092-uftc8inx 1621 2 maintains maintain VBZ cord-010092-uftc8inx 1621 3 a a DT cord-010092-uftc8inx 1621 4 nation nation NN cord-010092-uftc8inx 1621 5 - - HYPH cord-010092-uftc8inx 1621 6 wide wide JJ cord-010092-uftc8inx 1621 7 package package NN cord-010092-uftc8inx 1621 8 delivery delivery NN cord-010092-uftc8inx 1621 9 system system NN cord-010092-uftc8inx 1621 10 based base VBN cord-010092-uftc8inx 1621 11 on on IN cord-010092-uftc8inx 1621 12 the the DT cord-010092-uftc8inx 1621 13 scheduled schedule VBN cord-010092-uftc8inx 1621 14 bus bus NN cord-010092-uftc8inx 1621 15 route route NN cord-010092-uftc8inx 1621 16 network network NN cord-010092-uftc8inx 1621 17 . . . cord-010092-uftc8inx 1622 1 Matkahuolto Matkahuolto NNP cord-010092-uftc8inx 1622 2 LTD LTD NNP cord-010092-uftc8inx 1622 3 is be VBZ cord-010092-uftc8inx 1622 4 used use VBN cord-010092-uftc8inx 1622 5 to to TO cord-010092-uftc8inx 1622 6 transport transport VB cord-010092-uftc8inx 1622 7 donor donor NN cord-010092-uftc8inx 1622 8 testing testing NN cord-010092-uftc8inx 1622 9 samples sample NNS cord-010092-uftc8inx 1622 10 from from IN cord-010092-uftc8inx 1622 11 the the DT cord-010092-uftc8inx 1622 12 donation donation NN cord-010092-uftc8inx 1622 13 sites site NNS cord-010092-uftc8inx 1622 14 to to IN cord-010092-uftc8inx 1622 15 the the DT cord-010092-uftc8inx 1622 16 central central JJ cord-010092-uftc8inx 1622 17 laboratory laboratory NN cord-010092-uftc8inx 1622 18 . . . cord-010092-uftc8inx 1623 1 By by IN cord-010092-uftc8inx 1623 2 this this DT cord-010092-uftc8inx 1623 3 arrangement arrangement NN cord-010092-uftc8inx 1623 4 it -PRON- PRP cord-010092-uftc8inx 1623 5 is be VBZ cord-010092-uftc8inx 1623 6 possible possible JJ cord-010092-uftc8inx 1623 7 to to TO cord-010092-uftc8inx 1623 8 obtain obtain VB cord-010092-uftc8inx 1623 9 most most JJS cord-010092-uftc8inx 1623 10 of of IN cord-010092-uftc8inx 1623 11 the the DT cord-010092-uftc8inx 1623 12 donor donor NN cord-010092-uftc8inx 1623 13 samples sample NNS cord-010092-uftc8inx 1623 14 to to IN cord-010092-uftc8inx 1623 15 the the DT cord-010092-uftc8inx 1623 16 laboratory laboratory NN cord-010092-uftc8inx 1623 17 around around IN cord-010092-uftc8inx 1623 18 midnight midnight NN cord-010092-uftc8inx 1623 19 , , , cord-010092-uftc8inx 1623 20 which which WDT cord-010092-uftc8inx 1623 21 significantly significantly RB cord-010092-uftc8inx 1623 22 speeds speed VBZ cord-010092-uftc8inx 1623 23 up up RP cord-010092-uftc8inx 1623 24 the the DT cord-010092-uftc8inx 1623 25 completion completion NN cord-010092-uftc8inx 1623 26 of of IN cord-010092-uftc8inx 1623 27 laboratory laboratory NN cord-010092-uftc8inx 1623 28 results result NNS cord-010092-uftc8inx 1623 29 . . . cord-010092-uftc8inx 1624 1 The the DT cord-010092-uftc8inx 1624 2 third third JJ cord-010092-uftc8inx 1624 3 logistics logistics NN cord-010092-uftc8inx 1624 4 partner partner NN cord-010092-uftc8inx 1624 5 is be VBZ cord-010092-uftc8inx 1624 6 JetPak JetPak NNP cord-010092-uftc8inx 1624 7 Finland Finland NNP cord-010092-uftc8inx 1624 8 Ltd Ltd NNP cord-010092-uftc8inx 1624 9 , , , cord-010092-uftc8inx 1624 10 which which WDT cord-010092-uftc8inx 1624 11 operates operate VBZ cord-010092-uftc8inx 1624 12 the the DT cord-010092-uftc8inx 1624 13 air air NN cord-010092-uftc8inx 1624 14 freight freight NN cord-010092-uftc8inx 1624 15 for for IN cord-010092-uftc8inx 1624 16 the the DT cord-010092-uftc8inx 1624 17 national national JJ cord-010092-uftc8inx 1624 18 flight flight NN cord-010092-uftc8inx 1624 19 company company NN cord-010092-uftc8inx 1624 20 Finnair Finnair NNP cord-010092-uftc8inx 1624 21 . . . cord-010092-uftc8inx 1625 1 Blood blood NN cord-010092-uftc8inx 1625 2 transfusion transfusion NN cord-010092-uftc8inx 1625 3 services service NNS cord-010092-uftc8inx 1625 4 can can MD cord-010092-uftc8inx 1625 5 be be VB cord-010092-uftc8inx 1625 6 managed manage VBN cord-010092-uftc8inx 1625 7 centrally centrally RB cord-010092-uftc8inx 1625 8 in in IN cord-010092-uftc8inx 1625 9 a a DT cord-010092-uftc8inx 1625 10 large large JJ cord-010092-uftc8inx 1625 11 sparsely sparsely RB cord-010092-uftc8inx 1625 12 populated populated JJ cord-010092-uftc8inx 1625 13 country country NN cord-010092-uftc8inx 1625 14 in in IN cord-010092-uftc8inx 1625 15 a a DT cord-010092-uftc8inx 1625 16 manner manner NN cord-010092-uftc8inx 1625 17 that that WDT cord-010092-uftc8inx 1625 18 is be VBZ cord-010092-uftc8inx 1625 19 of of IN cord-010092-uftc8inx 1625 20 high high JJ cord-010092-uftc8inx 1625 21 quality quality NN cord-010092-uftc8inx 1625 22 , , , cord-010092-uftc8inx 1625 23 safe safe JJ cord-010092-uftc8inx 1625 24 and and CC cord-010092-uftc8inx 1625 25 cost cost VBD cord-010092-uftc8inx 1625 26 effective effective JJ cord-010092-uftc8inx 1625 27 . . . cord-010092-uftc8inx 1626 1 However however RB cord-010092-uftc8inx 1626 2 , , , cord-010092-uftc8inx 1626 3 the the DT cord-010092-uftc8inx 1626 4 supply supply NN cord-010092-uftc8inx 1626 5 chain chain NN cord-010092-uftc8inx 1626 6 has have VBZ cord-010092-uftc8inx 1626 7 to to TO cord-010092-uftc8inx 1626 8 be be VB cord-010092-uftc8inx 1626 9 planned plan VBN cord-010092-uftc8inx 1626 10 carefully carefully RB cord-010092-uftc8inx 1626 11 . . . cord-010092-uftc8inx 1627 1 Background background NN cord-010092-uftc8inx 1627 2 : : : cord-010092-uftc8inx 1628 1 Elearning Elearning NNP cord-010092-uftc8inx 1628 2 is be VBZ cord-010092-uftc8inx 1628 3 a a DT cord-010092-uftc8inx 1628 4 divisive divisive JJ cord-010092-uftc8inx 1628 5 topic topic NN cord-010092-uftc8inx 1628 6 . . . cord-010092-uftc8inx 1629 1 It -PRON- PRP cord-010092-uftc8inx 1629 2 is be VBZ cord-010092-uftc8inx 1629 3 often often RB cord-010092-uftc8inx 1629 4 criticised criticise VBN cord-010092-uftc8inx 1629 5 as as IN cord-010092-uftc8inx 1629 6 an an DT cord-010092-uftc8inx 1629 7 inferior inferior JJ cord-010092-uftc8inx 1629 8 form form NN cord-010092-uftc8inx 1629 9 of of IN cord-010092-uftc8inx 1629 10 education education NN cord-010092-uftc8inx 1629 11 while while IN cord-010092-uftc8inx 1629 12 simultaneously simultaneously RB cord-010092-uftc8inx 1629 13 being be VBG cord-010092-uftc8inx 1629 14 promoted promote VBN cord-010092-uftc8inx 1629 15 as as IN cord-010092-uftc8inx 1629 16 a a DT cord-010092-uftc8inx 1629 17 means means NN cord-010092-uftc8inx 1629 18 to to TO cord-010092-uftc8inx 1629 19 provide provide VB cord-010092-uftc8inx 1629 20 education education NN cord-010092-uftc8inx 1629 21 to to IN cord-010092-uftc8inx 1629 22 large large JJ cord-010092-uftc8inx 1629 23 numbers number NNS cord-010092-uftc8inx 1629 24 of of IN cord-010092-uftc8inx 1629 25 people people NNS cord-010092-uftc8inx 1629 26 in in IN cord-010092-uftc8inx 1629 27 a a DT cord-010092-uftc8inx 1629 28 consistent consistent JJ cord-010092-uftc8inx 1629 29 , , , cord-010092-uftc8inx 1629 30 cost cost NN cord-010092-uftc8inx 1629 31 - - HYPH cord-010092-uftc8inx 1629 32 effective effective JJ cord-010092-uftc8inx 1629 33 manner manner NN cord-010092-uftc8inx 1629 34 . . . cord-010092-uftc8inx 1630 1 BloodSafe BloodSafe NNP cord-010092-uftc8inx 1630 2 eLearning eLearning NNP cord-010092-uftc8inx 1630 3 Australia Australia NNP cord-010092-uftc8inx 1630 4 ( ( -LRB- cord-010092-uftc8inx 1630 5 BEA BEA NNP cord-010092-uftc8inx 1630 6 ) ) -RRB- cord-010092-uftc8inx 1630 7 is be VBZ cord-010092-uftc8inx 1630 8 a a DT cord-010092-uftc8inx 1630 9 government government NN cord-010092-uftc8inx 1630 10 - - HYPH cord-010092-uftc8inx 1630 11 funded fund VBN cord-010092-uftc8inx 1630 12 blood blood NN cord-010092-uftc8inx 1630 13 transfusion transfusion NN cord-010092-uftc8inx 1630 14 education education NN cord-010092-uftc8inx 1630 15 program program NN cord-010092-uftc8inx 1630 16 that that WDT cord-010092-uftc8inx 1630 17 commenced commence VBD cord-010092-uftc8inx 1630 18 in in IN cord-010092-uftc8inx 1630 19 2007 2007 CD cord-010092-uftc8inx 1630 20 and and CC cord-010092-uftc8inx 1630 21 provides provide VBZ cord-010092-uftc8inx 1630 22 courses course NNS cord-010092-uftc8inx 1630 23 in in IN cord-010092-uftc8inx 1630 24 clinical clinical JJ cord-010092-uftc8inx 1630 25 transfusion transfusion NN cord-010092-uftc8inx 1630 26 practice practice NN cord-010092-uftc8inx 1630 27 and and CC cord-010092-uftc8inx 1630 28 patient patient JJ cord-010092-uftc8inx 1630 29 blood blood NN cord-010092-uftc8inx 1630 30 management management NN cord-010092-uftc8inx 1630 31 ( ( -LRB- cord-010092-uftc8inx 1630 32 PBM PBM NNP cord-010092-uftc8inx 1630 33 ) ) -RRB- cord-010092-uftc8inx 1630 34 including include VBG cord-010092-uftc8inx 1630 35 : : : cord-010092-uftc8inx 1630 36 -Clinical -Clinical NNP cord-010092-uftc8inx 1630 37 Transfusion transfusion NN cord-010092-uftc8inx 1630 38 Practice Practice NNP cord-010092-uftc8inx 1630 39 ( ( -LRB- cord-010092-uftc8inx 1630 40 4 4 CD cord-010092-uftc8inx 1630 41 courses course NNS cord-010092-uftc8inx 1630 42 ) ) -RRB- cord-010092-uftc8inx 1630 43 -PBM -PBM : cord-010092-uftc8inx 1630 44 : : : cord-010092-uftc8inx 1630 45 General general JJ cord-010092-uftc8inx 1630 46 ( ( -LRB- cord-010092-uftc8inx 1630 47 7 7 CD cord-010092-uftc8inx 1630 48 courses course NNS cord-010092-uftc8inx 1630 49 ) ) -RRB- cord-010092-uftc8inx 1630 50 -PBM -PBM : cord-010092-uftc8inx 1630 51 : : : cord-010092-uftc8inx 1630 52 Medical medical JJ cord-010092-uftc8inx 1630 53 ( ( -LRB- cord-010092-uftc8inx 1630 54 6 6 CD cord-010092-uftc8inx 1630 55 courses course NNS cord-010092-uftc8inx 1630 56 ) ) -RRB- cord-010092-uftc8inx 1630 57 -PBM -PBM : cord-010092-uftc8inx 1630 58 : : : cord-010092-uftc8inx 1630 59 Acute Acute NNP cord-010092-uftc8inx 1630 60 Care Care NNP cord-010092-uftc8inx 1630 61 and and CC cord-010092-uftc8inx 1630 62 Surgical Surgical NNP cord-010092-uftc8inx 1630 63 ( ( -LRB- cord-010092-uftc8inx 1630 64 4 4 CD cord-010092-uftc8inx 1630 65 courses course NNS cord-010092-uftc8inx 1630 66 ) ) -RRB- cord-010092-uftc8inx 1630 67 -PBM -PBM : cord-010092-uftc8inx 1630 68 : : : cord-010092-uftc8inx 1630 69 Obstetrics Obstetrics NNP cord-010092-uftc8inx 1630 70 and and CC cord-010092-uftc8inx 1630 71 Maternity Maternity NNP cord-010092-uftc8inx 1630 72 ( ( -LRB- cord-010092-uftc8inx 1630 73 3 3 CD cord-010092-uftc8inx 1630 74 courses course NNS cord-010092-uftc8inx 1630 75 ) ) -RRB- cord-010092-uftc8inx 1630 76 -PBM -PBM : cord-010092-uftc8inx 1630 77 : : : cord-010092-uftc8inx 1630 78 Neonates Neonates NNPS cord-010092-uftc8inx 1630 79 and and CC cord-010092-uftc8inx 1630 80 Paediatrics Paediatrics NNP cord-010092-uftc8inx 1630 81 ( ( -LRB- cord-010092-uftc8inx 1630 82 7 7 CD cord-010092-uftc8inx 1630 83 courses course NNS cord-010092-uftc8inx 1630 84 ) ) -RRB- cord-010092-uftc8inx 1631 1 Aims aim VBZ cord-010092-uftc8inx 1631 2 : : : cord-010092-uftc8inx 1631 3 To to TO cord-010092-uftc8inx 1631 4 determine determine VB cord-010092-uftc8inx 1631 5 the the DT cord-010092-uftc8inx 1631 6 engagement engagement NN cord-010092-uftc8inx 1631 7 , , , cord-010092-uftc8inx 1631 8 outcomes outcome NNS cord-010092-uftc8inx 1631 9 and and CC cord-010092-uftc8inx 1631 10 impact impact NN cord-010092-uftc8inx 1631 11 of of IN cord-010092-uftc8inx 1631 12 learning learning NN cord-010092-uftc8inx 1631 13 of of IN cord-010092-uftc8inx 1631 14 BloodSafe BloodSafe NNP cord-010092-uftc8inx 1631 15 eLearning eLearning NNP cord-010092-uftc8inx 1631 16 Australia Australia NNP cord-010092-uftc8inx 1631 17 courses course NNS cord-010092-uftc8inx 1631 18 . . . cord-010092-uftc8inx 1632 1 Methods method NNS cord-010092-uftc8inx 1632 2 : : : cord-010092-uftc8inx 1633 1 A a DT cord-010092-uftc8inx 1633 2 retrospective retrospective JJ cord-010092-uftc8inx 1633 3 analysis analysis NN cord-010092-uftc8inx 1633 4 of of IN cord-010092-uftc8inx 1633 5 user user NN cord-010092-uftc8inx 1633 6 registrations registration NNS cord-010092-uftc8inx 1633 7 , , , cord-010092-uftc8inx 1633 8 course course NN cord-010092-uftc8inx 1633 9 completion completion NN cord-010092-uftc8inx 1633 10 records record NNS cord-010092-uftc8inx 1633 11 , , , cord-010092-uftc8inx 1633 12 course course NN cord-010092-uftc8inx 1633 13 evaluation evaluation NN cord-010092-uftc8inx 1633 14 data datum NNS cord-010092-uftc8inx 1633 15 and and CC cord-010092-uftc8inx 1633 16 red red JJ cord-010092-uftc8inx 1633 17 cell cell NN cord-010092-uftc8inx 1633 18 usage usage NN cord-010092-uftc8inx 1633 19 in in IN cord-010092-uftc8inx 1633 20 Australia Australia NNP cord-010092-uftc8inx 1633 21 to to TO cord-010092-uftc8inx 1633 22 determine determine VB cord-010092-uftc8inx 1633 23 learner learner NN cord-010092-uftc8inx 1633 24 demographics demographic NNS cord-010092-uftc8inx 1633 25 , , , cord-010092-uftc8inx 1633 26 and and CC cord-010092-uftc8inx 1633 27 the the DT cord-010092-uftc8inx 1633 28 impact impact NN cord-010092-uftc8inx 1633 29 on on IN cord-010092-uftc8inx 1633 30 acquisition acquisition NN cord-010092-uftc8inx 1633 31 of of IN cord-010092-uftc8inx 1633 32 knowledge knowledge NN cord-010092-uftc8inx 1633 33 and and CC cord-010092-uftc8inx 1633 34 application application NN cord-010092-uftc8inx 1633 35 to to IN cord-010092-uftc8inx 1633 36 clinical clinical JJ cord-010092-uftc8inx 1633 37 practice practice NN cord-010092-uftc8inx 1633 38 . . . cord-010092-uftc8inx 1634 1 Results result NNS cord-010092-uftc8inx 1634 2 : : : cord-010092-uftc8inx 1635 1 In in IN cord-010092-uftc8inx 1635 2 the the DT cord-010092-uftc8inx 1635 3 period period NN cord-010092-uftc8inx 1635 4 from from IN cord-010092-uftc8inx 1635 5 1 1 CD cord-010092-uftc8inx 1635 6 July July NNP cord-010092-uftc8inx 1635 7 2007 2007 CD cord-010092-uftc8inx 1635 8 to to IN cord-010092-uftc8inx 1635 9 31 31 CD cord-010092-uftc8inx 1635 10 January January NNP cord-010092-uftc8inx 1635 11 2019 2019 CD cord-010092-uftc8inx 1635 12 : : : cord-010092-uftc8inx 1635 13 -489,600 -489,600 CD cord-010092-uftc8inx 1635 14 people people NNS cord-010092-uftc8inx 1635 15 registered register VBN cord-010092-uftc8inx 1635 16 as as IN cord-010092-uftc8inx 1635 17 learners learner NNS cord-010092-uftc8inx 1635 18 -1,072,299 -1,072,299 NFP cord-010092-uftc8inx 1635 19 courses course NNS cord-010092-uftc8inx 1635 20 were be VBD cord-010092-uftc8inx 1635 21 completed complete VBN cord-010092-uftc8inx 1635 22 -These -These JJR cord-010092-uftc8inx 1635 23 learners learner NNS cord-010092-uftc8inx 1635 24 came come VBD cord-010092-uftc8inx 1635 25 from from IN cord-010092-uftc8inx 1635 26 182 182 CD cord-010092-uftc8inx 1635 27 countries country NNS cord-010092-uftc8inx 1635 28 , , , cord-010092-uftc8inx 1635 29 with with IN cord-010092-uftc8inx 1635 30 11,141 11,141 CD cord-010092-uftc8inx 1635 31 ( ( -LRB- cord-010092-uftc8inx 1635 32 2.3 2.3 CD cord-010092-uftc8inx 1635 33 % % NN cord-010092-uftc8inx 1635 34 ) ) -RRB- cord-010092-uftc8inx 1635 35 of of IN cord-010092-uftc8inx 1635 36 them -PRON- PRP cord-010092-uftc8inx 1635 37 from from IN cord-010092-uftc8inx 1635 38 outside outside IN cord-010092-uftc8inx 1635 39 of of IN cord-010092-uftc8inx 1635 40 Australia Australia NNP cord-010092-uftc8inx 1635 41 . . . cord-010092-uftc8inx 1636 1 Analysis analysis NN cord-010092-uftc8inx 1636 2 by by IN cord-010092-uftc8inx 1636 3 profession profession NN cord-010092-uftc8inx 1636 4 shows show VBZ cord-010092-uftc8inx 1636 5 that that DT cord-010092-uftc8inx 1636 6 : : : cord-010092-uftc8inx 1636 7 -82.4 -82.4 CD cord-010092-uftc8inx 1636 8 % % NN cord-010092-uftc8inx 1636 9 are be VBP cord-010092-uftc8inx 1636 10 nurses nurse NNS cord-010092-uftc8inx 1636 11 and/or and/or CC cord-010092-uftc8inx 1636 12 midwives midwife NNS cord-010092-uftc8inx 1637 1 -11.2 -11.2 CD cord-010092-uftc8inx 1637 2 % % NN cord-010092-uftc8inx 1637 3 are be VBP cord-010092-uftc8inx 1637 4 medical medical JJ cord-010092-uftc8inx 1637 5 -6.4 -6.4 NN cord-010092-uftc8inx 1637 6 % % NN cord-010092-uftc8inx 1637 7 are be VBP cord-010092-uftc8inx 1637 8 laboratory laboratory NN cord-010092-uftc8inx 1637 9 , , , cord-010092-uftc8inx 1637 10 anaesthetic anaesthetic JJ cord-010092-uftc8inx 1637 11 technicians technician NNS cord-010092-uftc8inx 1637 12 or or CC cord-010092-uftc8inx 1637 13 other other JJ cord-010092-uftc8inx 1637 14 . . . cord-010092-uftc8inx 1638 1 Analysis analysis NN cord-010092-uftc8inx 1638 2 of of IN cord-010092-uftc8inx 1638 3 user user NN cord-010092-uftc8inx 1638 4 evaluation evaluation NN cord-010092-uftc8inx 1638 5 data datum NNS cord-010092-uftc8inx 1638 6 ( ( -LRB- cord-010092-uftc8inx 1638 7 n n NN cord-010092-uftc8inx 1638 8 = = SYM cord-010092-uftc8inx 1638 9 2,885 2,885 CD cord-010092-uftc8inx 1638 10 ) ) -RRB- cord-010092-uftc8inx 1638 11 from from IN cord-010092-uftc8inx 1638 12 1 1 CD cord-010092-uftc8inx 1638 13 April April NNP cord-010092-uftc8inx 1638 14 2015 2015 CD cord-010092-uftc8inx 1638 15 to to IN cord-010092-uftc8inx 1638 16 31 31 CD cord-010092-uftc8inx 1638 17 January January NNP cord-010092-uftc8inx 1638 18 2018 2018 CD cord-010092-uftc8inx 1638 19 shows show VBZ cord-010092-uftc8inx 1638 20 that that IN cord-010092-uftc8inx 1638 21 these these DT cord-010092-uftc8inx 1638 22 courses course NNS cord-010092-uftc8inx 1638 23 have have VBP cord-010092-uftc8inx 1638 24 a a DT cord-010092-uftc8inx 1638 25 positive positive JJ cord-010092-uftc8inx 1638 26 impact impact NN cord-010092-uftc8inx 1638 27 , , , cord-010092-uftc8inx 1638 28 with with IN cord-010092-uftc8inx 1638 29 88.7 88.7 CD cord-010092-uftc8inx 1638 30 % % NN cord-010092-uftc8inx 1638 31 of of IN cord-010092-uftc8inx 1638 32 respondents respondent NNS cord-010092-uftc8inx 1638 33 stating state VBG cord-010092-uftc8inx 1638 34 they -PRON- PRP cord-010092-uftc8inx 1638 35 gained gain VBD cord-010092-uftc8inx 1638 36 additional additional JJ cord-010092-uftc8inx 1638 37 knowledge knowledge NN cord-010092-uftc8inx 1638 38 , , , cord-010092-uftc8inx 1638 39 65.2 65.2 CD cord-010092-uftc8inx 1638 40 % % NN cord-010092-uftc8inx 1638 41 able able JJ cord-010092-uftc8inx 1638 42 to to TO cord-010092-uftc8inx 1638 43 make make VB cord-010092-uftc8inx 1638 44 changes change NNS cord-010092-uftc8inx 1638 45 to to IN cord-010092-uftc8inx 1638 46 clinical clinical JJ cord-010092-uftc8inx 1638 47 practice practice NN cord-010092-uftc8inx 1638 48 , , , cord-010092-uftc8inx 1638 49 and and CC cord-010092-uftc8inx 1638 50 88.2 88.2 CD cord-010092-uftc8inx 1638 51 % % NN cord-010092-uftc8inx 1638 52 reporting report VBG cord-010092-uftc8inx 1638 53 that that IN cord-010092-uftc8inx 1638 54 these these DT cord-010092-uftc8inx 1638 55 changes change NNS cord-010092-uftc8inx 1638 56 will will MD cord-010092-uftc8inx 1638 57 improve improve VB cord-010092-uftc8inx 1638 58 patient patient JJ cord-010092-uftc8inx 1638 59 safety safety NN cord-010092-uftc8inx 1638 60 and and CC cord-010092-uftc8inx 1638 61 outcomes outcome NNS cord-010092-uftc8inx 1638 62 . . . cord-010092-uftc8inx 1639 1 Analysis analysis NN cord-010092-uftc8inx 1639 2 of of IN cord-010092-uftc8inx 1639 3 international international JJ cord-010092-uftc8inx 1639 4 participants participant NNS cord-010092-uftc8inx 1639 5 shows show VBZ cord-010092-uftc8inx 1639 6 greater great JJR cord-010092-uftc8inx 1639 7 benefits benefit NNS cord-010092-uftc8inx 1639 8 with with IN cord-010092-uftc8inx 1639 9 93.5 93.5 CD cord-010092-uftc8inx 1639 10 % % NN cord-010092-uftc8inx 1639 11 gaining gain VBG cord-010092-uftc8inx 1639 12 knowledge knowledge NN cord-010092-uftc8inx 1639 13 , , , cord-010092-uftc8inx 1639 14 76.4 76.4 CD cord-010092-uftc8inx 1639 15 % % NN cord-010092-uftc8inx 1639 16 able able JJ cord-010092-uftc8inx 1639 17 to to TO cord-010092-uftc8inx 1639 18 change change VB cord-010092-uftc8inx 1639 19 their -PRON- PRP$ cord-010092-uftc8inx 1639 20 clinical clinical JJ cord-010092-uftc8inx 1639 21 practice practice NN cord-010092-uftc8inx 1639 22 and and CC cord-010092-uftc8inx 1639 23 91.9 91.9 CD cord-010092-uftc8inx 1639 24 % % NN cord-010092-uftc8inx 1639 25 believing believe VBG cord-010092-uftc8inx 1639 26 this this DT cord-010092-uftc8inx 1639 27 will will MD cord-010092-uftc8inx 1639 28 improve improve VB cord-010092-uftc8inx 1639 29 patient patient JJ cord-010092-uftc8inx 1639 30 outcomes outcome NNS cord-010092-uftc8inx 1639 31 . . . cord-010092-uftc8inx 1640 1 Analysis analysis NN cord-010092-uftc8inx 1640 2 of of IN cord-010092-uftc8inx 1640 3 red red JJ cord-010092-uftc8inx 1640 4 cell cell NN cord-010092-uftc8inx 1640 5 usage usage NN cord-010092-uftc8inx 1640 6 in in IN cord-010092-uftc8inx 1640 7 Australia Australia NNP cord-010092-uftc8inx 1640 8 shows show VBZ cord-010092-uftc8inx 1640 9 that that IN cord-010092-uftc8inx 1640 10 since since IN cord-010092-uftc8inx 1640 11 2012 2012 CD cord-010092-uftc8inx 1640 12 there there EX cord-010092-uftc8inx 1640 13 has have VBZ cord-010092-uftc8inx 1640 14 been be VBN cord-010092-uftc8inx 1640 15 a a DT cord-010092-uftc8inx 1640 16 21.1 21.1 CD cord-010092-uftc8inx 1640 17 % % NN cord-010092-uftc8inx 1640 18 reduction reduction NN cord-010092-uftc8inx 1640 19 in in IN cord-010092-uftc8inx 1640 20 red red JJ cord-010092-uftc8inx 1640 21 cells cell NNS cord-010092-uftc8inx 1640 22 issued issue VBN cord-010092-uftc8inx 1640 23 . . . cord-010092-uftc8inx 1641 1 This this DT cord-010092-uftc8inx 1641 2 has have VBZ cord-010092-uftc8inx 1641 3 been be VBN cord-010092-uftc8inx 1641 4 achieved achieve VBN cord-010092-uftc8inx 1641 5 through through IN cord-010092-uftc8inx 1641 6 a a DT cord-010092-uftc8inx 1641 7 number number NN cord-010092-uftc8inx 1641 8 of of IN cord-010092-uftc8inx 1641 9 PBM PBM NNP cord-010092-uftc8inx 1641 10 activities activity NNS cord-010092-uftc8inx 1641 11 including include VBG cord-010092-uftc8inx 1641 12 development development NN cord-010092-uftc8inx 1641 13 of of IN cord-010092-uftc8inx 1641 14 guidelines guideline NNS cord-010092-uftc8inx 1641 15 , , , cord-010092-uftc8inx 1641 16 research research NN cord-010092-uftc8inx 1641 17 and and CC cord-010092-uftc8inx 1641 18 audits audits NN cord-010092-uftc8inx 1641 19 , , , cord-010092-uftc8inx 1641 20 education education NN cord-010092-uftc8inx 1641 21 , , , cord-010092-uftc8inx 1641 22 waste waste NN cord-010092-uftc8inx 1641 23 reduction reduction NN cord-010092-uftc8inx 1641 24 strategies strategy NNS cord-010092-uftc8inx 1641 25 , , , cord-010092-uftc8inx 1641 26 and and CC cord-010092-uftc8inx 1641 27 promotional promotional JJ cord-010092-uftc8inx 1641 28 campaigns campaign NNS cord-010092-uftc8inx 1641 29 . . . cord-010092-uftc8inx 1642 1 BloodSafe BloodSafe NNP cord-010092-uftc8inx 1642 2 eLearning eLearning NNP cord-010092-uftc8inx 1642 3 Australia Australia NNP cord-010092-uftc8inx 1642 4 courses course NNS cord-010092-uftc8inx 1642 5 on on IN cord-010092-uftc8inx 1642 6 PBM PBM NNP cord-010092-uftc8inx 1642 7 were be VBD cord-010092-uftc8inx 1642 8 released release VBN cord-010092-uftc8inx 1642 9 in in IN cord-010092-uftc8inx 1642 10 2012 2012 CD cord-010092-uftc8inx 1642 11 and and CC cord-010092-uftc8inx 1642 12 are be VBP cord-010092-uftc8inx 1642 13 one one CD cord-010092-uftc8inx 1642 14 part part NN cord-010092-uftc8inx 1642 15 of of IN cord-010092-uftc8inx 1642 16 this this DT cord-010092-uftc8inx 1642 17 PBM PBM NNP cord-010092-uftc8inx 1642 18 activity activity NN cord-010092-uftc8inx 1642 19 , , , cord-010092-uftc8inx 1642 20 and and CC cord-010092-uftc8inx 1642 21 it -PRON- PRP cord-010092-uftc8inx 1642 22 is be VBZ cord-010092-uftc8inx 1642 23 notable notable JJ cord-010092-uftc8inx 1642 24 that that IN cord-010092-uftc8inx 1642 25 these these DT cord-010092-uftc8inx 1642 26 courses course NNS cord-010092-uftc8inx 1642 27 have have VBP cord-010092-uftc8inx 1642 28 the the DT cord-010092-uftc8inx 1642 29 widest wide JJS cord-010092-uftc8inx 1642 30 reach reach NN cord-010092-uftc8inx 1642 31 as as IN cord-010092-uftc8inx 1642 32 they -PRON- PRP cord-010092-uftc8inx 1642 33 are be VBP cord-010092-uftc8inx 1642 34 undertaken undertake VBN cord-010092-uftc8inx 1642 35 by by IN cord-010092-uftc8inx 1642 36 a a DT cord-010092-uftc8inx 1642 37 large large JJ cord-010092-uftc8inx 1642 38 proportion proportion NN cord-010092-uftc8inx 1642 39 of of IN cord-010092-uftc8inx 1642 40 doctors doctor NNS cord-010092-uftc8inx 1642 41 , , , cord-010092-uftc8inx 1642 42 nurses nurse NNS cord-010092-uftc8inx 1642 43 and and CC cord-010092-uftc8inx 1642 44 midwives midwife NNS cord-010092-uftc8inx 1642 45 in in IN cord-010092-uftc8inx 1642 46 Australia Australia NNP cord-010092-uftc8inx 1642 47 who who WP cord-010092-uftc8inx 1642 48 are be VBP cord-010092-uftc8inx 1642 49 not not RB cord-010092-uftc8inx 1642 50 directly directly RB cord-010092-uftc8inx 1642 51 involved involve VBN cord-010092-uftc8inx 1642 52 with with IN cord-010092-uftc8inx 1642 53 the the DT cord-010092-uftc8inx 1642 54 blood blood NN cord-010092-uftc8inx 1642 55 sector sector NN cord-010092-uftc8inx 1642 56 . . . cord-010092-uftc8inx 1643 1 Stakeholder stakeholder NN cord-010092-uftc8inx 1643 2 feedback feedback NN cord-010092-uftc8inx 1643 3 shows show VBZ cord-010092-uftc8inx 1643 4 that that IN cord-010092-uftc8inx 1643 5 the the DT cord-010092-uftc8inx 1643 6 program program NN cord-010092-uftc8inx 1643 7 provides provide VBZ cord-010092-uftc8inx 1643 8 credible credible JJ cord-010092-uftc8inx 1643 9 , , , cord-010092-uftc8inx 1643 10 consistent consistent JJ cord-010092-uftc8inx 1643 11 education education NN cord-010092-uftc8inx 1643 12 that that WDT cord-010092-uftc8inx 1643 13 is be VBZ cord-010092-uftc8inx 1643 14 cost cost NN cord-010092-uftc8inx 1643 15 - - HYPH cord-010092-uftc8inx 1643 16 effective effective JJ cord-010092-uftc8inx 1643 17 , , , cord-010092-uftc8inx 1643 18 reduces reduce VBZ cord-010092-uftc8inx 1643 19 duplication duplication NN cord-010092-uftc8inx 1643 20 , , , cord-010092-uftc8inx 1643 21 is be VBZ cord-010092-uftc8inx 1643 22 ' ' `` cord-010092-uftc8inx 1643 23 best good JJS cord-010092-uftc8inx 1643 24 - - HYPH cord-010092-uftc8inx 1643 25 practice practice NN cord-010092-uftc8inx 1643 26 ' ' '' cord-010092-uftc8inx 1643 27 elearning elearning NN cord-010092-uftc8inx 1643 28 , , , cord-010092-uftc8inx 1643 29 is be VBZ cord-010092-uftc8inx 1643 30 readily readily RB cord-010092-uftc8inx 1643 31 accessible accessible JJ cord-010092-uftc8inx 1643 32 , , , cord-010092-uftc8inx 1643 33 and and CC cord-010092-uftc8inx 1643 34 allows allow VBZ cord-010092-uftc8inx 1643 35 institutions institution NNS cord-010092-uftc8inx 1643 36 to to TO cord-010092-uftc8inx 1643 37 focus focus VB cord-010092-uftc8inx 1643 38 on on IN cord-010092-uftc8inx 1643 39 the the DT cord-010092-uftc8inx 1643 40 development development NN cord-010092-uftc8inx 1643 41 of of IN cord-010092-uftc8inx 1643 42 practical practical JJ cord-010092-uftc8inx 1643 43 transfusion transfusion NN cord-010092-uftc8inx 1643 44 skills skill NNS cord-010092-uftc8inx 1643 45 . . . cord-010092-uftc8inx 1644 1 Summary Summary NNP cord-010092-uftc8inx 1644 2 / / SYM cord-010092-uftc8inx 1644 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 1644 4 : : : cord-010092-uftc8inx 1645 1 This this DT cord-010092-uftc8inx 1645 2 analysis analysis NN cord-010092-uftc8inx 1645 3 shows show VBZ cord-010092-uftc8inx 1645 4 that that IN cord-010092-uftc8inx 1645 5 elearning elearning NNP cord-010092-uftc8inx 1645 6 is be VBZ cord-010092-uftc8inx 1645 7 a a DT cord-010092-uftc8inx 1645 8 well well RB cord-010092-uftc8inx 1645 9 - - HYPH cord-010092-uftc8inx 1645 10 accepted accept VBN cord-010092-uftc8inx 1645 11 , , , cord-010092-uftc8inx 1645 12 wellutilised wellutilised JJ cord-010092-uftc8inx 1645 13 form form NN cord-010092-uftc8inx 1645 14 of of IN cord-010092-uftc8inx 1645 15 education education NN cord-010092-uftc8inx 1645 16 for for IN cord-010092-uftc8inx 1645 17 healthcare healthcare NN cord-010092-uftc8inx 1645 18 workers worker NNS cord-010092-uftc8inx 1645 19 to to TO cord-010092-uftc8inx 1645 20 learn learn VB cord-010092-uftc8inx 1645 21 about about IN cord-010092-uftc8inx 1645 22 clinical clinical JJ cord-010092-uftc8inx 1645 23 transfusion transfusion NN cord-010092-uftc8inx 1645 24 practice practice NN cord-010092-uftc8inx 1645 25 and and CC cord-010092-uftc8inx 1645 26 patient patient JJ cord-010092-uftc8inx 1645 27 blood blood NN cord-010092-uftc8inx 1645 28 management management NN cord-010092-uftc8inx 1645 29 , , , cord-010092-uftc8inx 1645 30 and and CC cord-010092-uftc8inx 1645 31 learners learner NNS cord-010092-uftc8inx 1645 32 gain gain VBP cord-010092-uftc8inx 1645 33 knowledge knowledge NN cord-010092-uftc8inx 1645 34 that that WDT cord-010092-uftc8inx 1645 35 can can MD cord-010092-uftc8inx 1645 36 change change VB cord-010092-uftc8inx 1645 37 their -PRON- PRP$ cord-010092-uftc8inx 1645 38 clinical clinical JJ cord-010092-uftc8inx 1645 39 practice practice NN cord-010092-uftc8inx 1645 40 and and CC cord-010092-uftc8inx 1645 41 improve improve VB cord-010092-uftc8inx 1645 42 patient patient JJ cord-010092-uftc8inx 1645 43 outcomes outcome NNS cord-010092-uftc8inx 1645 44 . . . cord-010092-uftc8inx 1646 1 It -PRON- PRP cord-010092-uftc8inx 1646 2 is be VBZ cord-010092-uftc8inx 1646 3 also also RB cord-010092-uftc8inx 1646 4 likely likely JJ cord-010092-uftc8inx 1646 5 that that IN cord-010092-uftc8inx 1646 6 these these DT cord-010092-uftc8inx 1646 7 courses course NNS cord-010092-uftc8inx 1646 8 have have VBP cord-010092-uftc8inx 1646 9 contributed contribute VBN cord-010092-uftc8inx 1646 10 to to TO cord-010092-uftc8inx 1646 11 better well JJR cord-010092-uftc8inx 1646 12 utilisation utilisation NN cord-010092-uftc8inx 1646 13 of of IN cord-010092-uftc8inx 1646 14 a a DT cord-010092-uftc8inx 1646 15 scarce scarce JJ cord-010092-uftc8inx 1646 16 , , , cord-010092-uftc8inx 1646 17 freely freely RB cord-010092-uftc8inx 1646 18 - - HYPH cord-010092-uftc8inx 1646 19 donated donate VBN cord-010092-uftc8inx 1646 20 resource resource NN cord-010092-uftc8inx 1646 21 . . . cord-010092-uftc8inx 1647 1 This this DT cord-010092-uftc8inx 1647 2 approach approach NN cord-010092-uftc8inx 1647 3 has have VBZ cord-010092-uftc8inx 1647 4 global global JJ cord-010092-uftc8inx 1647 5 reach reach NN cord-010092-uftc8inx 1647 6 and and CC cord-010092-uftc8inx 1647 7 availability availability NN cord-010092-uftc8inx 1647 8 , , , cord-010092-uftc8inx 1647 9 and and CC cord-010092-uftc8inx 1647 10 is be VBZ cord-010092-uftc8inx 1647 11 a a DT cord-010092-uftc8inx 1647 12 cost cost NN cord-010092-uftc8inx 1647 13 - - HYPH cord-010092-uftc8inx 1647 14 effective effective JJ cord-010092-uftc8inx 1647 15 model model NN cord-010092-uftc8inx 1647 16 for for IN cord-010092-uftc8inx 1647 17 improving improve VBG cord-010092-uftc8inx 1647 18 transfusion transfusion NN cord-010092-uftc8inx 1647 19 practice practice NN cord-010092-uftc8inx 1647 20 in in IN cord-010092-uftc8inx 1647 21 the the DT cord-010092-uftc8inx 1647 22 developing develop VBG cord-010092-uftc8inx 1647 23 world world NN cord-010092-uftc8inx 1647 24 by by IN cord-010092-uftc8inx 1647 25 providing provide VBG cord-010092-uftc8inx 1647 26 education education NN cord-010092-uftc8inx 1647 27 for for IN cord-010092-uftc8inx 1647 28 millions million NNS cord-010092-uftc8inx 1647 29 of of IN cord-010092-uftc8inx 1647 30 healthcare healthcare NN cord-010092-uftc8inx 1647 31 workers worker NNS cord-010092-uftc8inx 1647 32 . . . cord-010092-uftc8inx 1648 1 3D 3d JJ cord-010092-uftc8inx 1648 2 - - HYPH cord-010092-uftc8inx 1648 3 S14 S14 NNP cord-010092-uftc8inx 1648 4 - - HYPH cord-010092-uftc8inx 1648 5 03 03 CD cord-010092-uftc8inx 1648 6 PROSPECTIVE prospective JJ cord-010092-uftc8inx 1648 7 PLATELET platelet NN cord-010092-uftc8inx 1648 8 AUDITING auditing NN cord-010092-uftc8inx 1648 9 : : : cord-010092-uftc8inx 1648 10 ANALYSIS analysis NN cord-010092-uftc8inx 1648 11 OF of IN cord-010092-uftc8inx 1648 12 TRAINEE trainee NN cord-010092-uftc8inx 1648 13 COMPLIANCE COMPLIANCE NNS cord-010092-uftc8inx 1648 14 WITH with IN cord-010092-uftc8inx 1648 15 GUIDELINES GUIDELINES NNP cord-010092-uftc8inx 1648 16 Pathology Pathology NNP cord-010092-uftc8inx 1648 17 , , , cord-010092-uftc8inx 1648 18 Columbia Columbia NNP cord-010092-uftc8inx 1648 19 University University NNP cord-010092-uftc8inx 1648 20 , , , cord-010092-uftc8inx 1648 21 New New NNP cord-010092-uftc8inx 1648 22 York York NNP cord-010092-uftc8inx 1648 23 , , , cord-010092-uftc8inx 1648 24 United United NNP cord-010092-uftc8inx 1648 25 States States NNP cord-010092-uftc8inx 1648 26 Background Background NNP cord-010092-uftc8inx 1648 27 : : : cord-010092-uftc8inx 1649 1 Apheresis Apheresis NNP cord-010092-uftc8inx 1649 2 platelets platelet NNS cord-010092-uftc8inx 1649 3 are be VBP cord-010092-uftc8inx 1649 4 a a DT cord-010092-uftc8inx 1649 5 component component NN cord-010092-uftc8inx 1649 6 product product NN cord-010092-uftc8inx 1649 7 with with IN cord-010092-uftc8inx 1649 8 high high JJ cord-010092-uftc8inx 1649 9 cost cost NN cord-010092-uftc8inx 1649 10 and and CC cord-010092-uftc8inx 1649 11 limited limited JJ cord-010092-uftc8inx 1649 12 supply supply NN cord-010092-uftc8inx 1649 13 . . . cord-010092-uftc8inx 1650 1 Furthermore furthermore RB cord-010092-uftc8inx 1650 2 , , , cord-010092-uftc8inx 1650 3 there there EX cord-010092-uftc8inx 1650 4 is be VBZ cord-010092-uftc8inx 1650 5 a a DT cord-010092-uftc8inx 1650 6 potential potential NN cord-010092-uftc8inx 1650 7 for for IN cord-010092-uftc8inx 1650 8 severe severe JJ cord-010092-uftc8inx 1650 9 transfusion transfusion NN cord-010092-uftc8inx 1650 10 reactions reaction NNS cord-010092-uftc8inx 1650 11 associated associate VBN cord-010092-uftc8inx 1650 12 with with IN cord-010092-uftc8inx 1650 13 this this DT cord-010092-uftc8inx 1650 14 product product NN cord-010092-uftc8inx 1650 15 such such JJ cord-010092-uftc8inx 1650 16 as as IN cord-010092-uftc8inx 1650 17 transfusion transfusion NN cord-010092-uftc8inx 1650 18 related relate VBN cord-010092-uftc8inx 1650 19 lung lung NN cord-010092-uftc8inx 1650 20 injury injury NN cord-010092-uftc8inx 1650 21 ( ( -LRB- cord-010092-uftc8inx 1650 22 TRALI TRALI NNP cord-010092-uftc8inx 1650 23 ) ) -RRB- cord-010092-uftc8inx 1650 24 , , , cord-010092-uftc8inx 1650 25 and and CC cord-010092-uftc8inx 1650 26 sepsis sepsis NN cord-010092-uftc8inx 1650 27 due due IN cord-010092-uftc8inx 1650 28 to to IN cord-010092-uftc8inx 1650 29 bacterial bacterial JJ cord-010092-uftc8inx 1650 30 contamination contamination NN cord-010092-uftc8inx 1650 31 . . . cord-010092-uftc8inx 1651 1 Therefore therefore RB cord-010092-uftc8inx 1651 2 , , , cord-010092-uftc8inx 1651 3 transfusion transfusion NN cord-010092-uftc8inx 1651 4 guideline guideline NN cord-010092-uftc8inx 1651 5 compliance compliance NN cord-010092-uftc8inx 1651 6 is be VBZ cord-010092-uftc8inx 1651 7 closely closely RB cord-010092-uftc8inx 1651 8 monitored monitor VBN cord-010092-uftc8inx 1651 9 by by IN cord-010092-uftc8inx 1651 10 many many JJ cord-010092-uftc8inx 1651 11 centers center NNS cord-010092-uftc8inx 1651 12 . . . cord-010092-uftc8inx 1652 1 This this DT cord-010092-uftc8inx 1652 2 quality quality NN cord-010092-uftc8inx 1652 3 assurance assurance NN cord-010092-uftc8inx 1652 4 analysis analysis NN cord-010092-uftc8inx 1652 5 describes describe VBZ cord-010092-uftc8inx 1652 6 our -PRON- PRP$ cord-010092-uftc8inx 1652 7 experience experience NN cord-010092-uftc8inx 1652 8 with with IN cord-010092-uftc8inx 1652 9 prospective prospective JJ cord-010092-uftc8inx 1652 10 platelet platelet NN cord-010092-uftc8inx 1652 11 auditing auditing NN cord-010092-uftc8inx 1652 12 performed perform VBN cord-010092-uftc8inx 1652 13 by by IN cord-010092-uftc8inx 1652 14 physicians physician NNS cord-010092-uftc8inx 1652 15 in in IN cord-010092-uftc8inx 1652 16 pathology pathology NN cord-010092-uftc8inx 1652 17 residency residency NN cord-010092-uftc8inx 1652 18 training training NN cord-010092-uftc8inx 1652 19 . . . cord-010092-uftc8inx 1653 1 Aims aim VBZ cord-010092-uftc8inx 1653 2 : : : cord-010092-uftc8inx 1654 1 This this DT cord-010092-uftc8inx 1654 2 study study NN cord-010092-uftc8inx 1654 3 aims aim VBZ cord-010092-uftc8inx 1654 4 to to TO cord-010092-uftc8inx 1654 5 evaluate evaluate VB cord-010092-uftc8inx 1654 6 the the DT cord-010092-uftc8inx 1654 7 ability ability NN cord-010092-uftc8inx 1654 8 of of IN cord-010092-uftc8inx 1654 9 physicians physician NNS cord-010092-uftc8inx 1654 10 in in IN cord-010092-uftc8inx 1654 11 training training NN cord-010092-uftc8inx 1654 12 to to TO cord-010092-uftc8inx 1654 13 perform perform VB cord-010092-uftc8inx 1654 14 prospective prospective JJ cord-010092-uftc8inx 1654 15 auditing auditing NN cord-010092-uftc8inx 1654 16 and and CC cord-010092-uftc8inx 1654 17 compare compare VB cord-010092-uftc8inx 1654 18 policy policy NN cord-010092-uftc8inx 1654 19 compliance compliance NN cord-010092-uftc8inx 1654 20 for for IN cord-010092-uftc8inx 1654 21 different different JJ cord-010092-uftc8inx 1654 22 levels level NNS cord-010092-uftc8inx 1654 23 of of IN cord-010092-uftc8inx 1654 24 experience experience NN cord-010092-uftc8inx 1654 25 . . . cord-010092-uftc8inx 1655 1 Methods method NNS cord-010092-uftc8inx 1655 2 : : : cord-010092-uftc8inx 1655 3 This this DT cord-010092-uftc8inx 1655 4 is be VBZ cord-010092-uftc8inx 1655 5 a a DT cord-010092-uftc8inx 1655 6 quality quality NN cord-010092-uftc8inx 1655 7 assurance assurance NN cord-010092-uftc8inx 1655 8 analysis analysis NN cord-010092-uftc8inx 1655 9 of of IN cord-010092-uftc8inx 1655 10 a a DT cord-010092-uftc8inx 1655 11 prospective prospective JJ cord-010092-uftc8inx 1655 12 platelet platelet NN cord-010092-uftc8inx 1655 13 audit audit NN cord-010092-uftc8inx 1655 14 program program NN cord-010092-uftc8inx 1655 15 for for IN cord-010092-uftc8inx 1655 16 a a DT cord-010092-uftc8inx 1655 17 12-month 12-month JJ cord-010092-uftc8inx 1655 18 period period NN cord-010092-uftc8inx 1655 19 ( ( -LRB- cord-010092-uftc8inx 1655 20 January January NNP cord-010092-uftc8inx 1655 21 2018-December 2018-december CD cord-010092-uftc8inx 1655 22 2018 2018 CD cord-010092-uftc8inx 1655 23 ) ) -RRB- cord-010092-uftc8inx 1655 24 . . . cord-010092-uftc8inx 1656 1 The the DT cord-010092-uftc8inx 1656 2 blood blood NN cord-010092-uftc8inx 1656 3 bank bank NN cord-010092-uftc8inx 1656 4 paged page VBD cord-010092-uftc8inx 1656 5 the the DT cord-010092-uftc8inx 1656 6 on on IN cord-010092-uftc8inx 1656 7 call call NN cord-010092-uftc8inx 1656 8 physician physician NN cord-010092-uftc8inx 1656 9 any any DT cord-010092-uftc8inx 1656 10 time time NN cord-010092-uftc8inx 1656 11 an an DT cord-010092-uftc8inx 1656 12 order order NN cord-010092-uftc8inx 1656 13 was be VBD cord-010092-uftc8inx 1656 14 placed place VBN cord-010092-uftc8inx 1656 15 for for IN cord-010092-uftc8inx 1656 16 a a DT cord-010092-uftc8inx 1656 17 patient patient NN cord-010092-uftc8inx 1656 18 with with IN cord-010092-uftc8inx 1656 19 a a DT cord-010092-uftc8inx 1656 20 platelet platelet NN cord-010092-uftc8inx 1656 21 count count NN cord-010092-uftc8inx 1656 22 of of IN cord-010092-uftc8inx 1656 23 > > XX cord-010092-uftc8inx 1656 24 50,000 50,000 CD cord-010092-uftc8inx 1657 1 /ll /ll LS cord-010092-uftc8inx 1657 2 , , , cord-010092-uftc8inx 1657 3 ≥2 ≥2 NNP cord-010092-uftc8inx 1657 4 doses dose NNS cord-010092-uftc8inx 1657 5 of of IN cord-010092-uftc8inx 1657 6 platelets platelet NNS cord-010092-uftc8inx 1657 7 with with IN cord-010092-uftc8inx 1657 8 no no DT cord-010092-uftc8inx 1657 9 interim interim JJ cord-010092-uftc8inx 1657 10 repeat repeat NN cord-010092-uftc8inx 1657 11 count count NN cord-010092-uftc8inx 1657 12 , , , cord-010092-uftc8inx 1657 13 or or CC cord-010092-uftc8inx 1657 14 an an DT cord-010092-uftc8inx 1657 15 unknown unknown JJ cord-010092-uftc8inx 1657 16 platelet platelet NN cord-010092-uftc8inx 1657 17 count count NN cord-010092-uftc8inx 1657 18 . . . cord-010092-uftc8inx 1658 1 Audit audit NN cord-010092-uftc8inx 1658 2 records record NNS cord-010092-uftc8inx 1658 3 created create VBN cord-010092-uftc8inx 1658 4 by by IN cord-010092-uftc8inx 1658 5 physician physician NN cord-010092-uftc8inx 1658 6 trainees trainee NNS cord-010092-uftc8inx 1658 7 in in IN cord-010092-uftc8inx 1658 8 their -PRON- PRP$ cord-010092-uftc8inx 1658 9 first first JJ cord-010092-uftc8inx 1658 10 post post NN cord-010092-uftc8inx 1658 11 graduate graduate NN cord-010092-uftc8inx 1658 12 year year NN cord-010092-uftc8inx 1658 13 ( ( -LRB- cord-010092-uftc8inx 1658 14 PGY1 PGY1 NNP cord-010092-uftc8inx 1658 15 ) ) -RRB- cord-010092-uftc8inx 1658 16 were be VBD cord-010092-uftc8inx 1658 17 compared compare VBN cord-010092-uftc8inx 1658 18 to to IN cord-010092-uftc8inx 1658 19 subsequent subsequent JJ cord-010092-uftc8inx 1658 20 years year NNS cord-010092-uftc8inx 1658 21 ( ( -LRB- cord-010092-uftc8inx 1658 22 PGY pgy NN cord-010092-uftc8inx 1658 23 > > XX cord-010092-uftc8inx 1658 24 1 1 CD cord-010092-uftc8inx 1658 25 ) ) -RRB- cord-010092-uftc8inx 1658 26 . . . cord-010092-uftc8inx 1659 1 Information information NN cord-010092-uftc8inx 1659 2 collected collect VBN cord-010092-uftc8inx 1659 3 included include VBD cord-010092-uftc8inx 1659 4 the the DT cord-010092-uftc8inx 1659 5 total total JJ cord-010092-uftc8inx 1659 6 number number NN cord-010092-uftc8inx 1659 7 of of IN cord-010092-uftc8inx 1659 8 doses dose NNS cord-010092-uftc8inx 1659 9 requiring require VBG cord-010092-uftc8inx 1659 10 approval approval NN cord-010092-uftc8inx 1659 11 , , , cord-010092-uftc8inx 1659 12 number number NN cord-010092-uftc8inx 1659 13 of of IN cord-010092-uftc8inx 1659 14 products product NNS cord-010092-uftc8inx 1659 15 approved approve VBN cord-010092-uftc8inx 1659 16 , , , cord-010092-uftc8inx 1659 17 training training NN cord-010092-uftc8inx 1659 18 year year NN cord-010092-uftc8inx 1659 19 for for IN cord-010092-uftc8inx 1659 20 the the DT cord-010092-uftc8inx 1659 21 approving approve VBG cord-010092-uftc8inx 1659 22 physician physician NN cord-010092-uftc8inx 1659 23 , , , cord-010092-uftc8inx 1659 24 and and CC cord-010092-uftc8inx 1659 25 transfusion transfusion NN cord-010092-uftc8inx 1659 26 indication indication NN cord-010092-uftc8inx 1659 27 . . . cord-010092-uftc8inx 1660 1 Cost cost NN cord-010092-uftc8inx 1660 2 analyses analysis NNS cord-010092-uftc8inx 1660 3 assumed assume VBD cord-010092-uftc8inx 1660 4 $ $ $ cord-010092-uftc8inx 1660 5 500 500 CD cord-010092-uftc8inx 1660 6 for for IN cord-010092-uftc8inx 1660 7 a a DT cord-010092-uftc8inx 1660 8 dose dose NN cord-010092-uftc8inx 1660 9 of of IN cord-010092-uftc8inx 1660 10 platelets platelet NNS cord-010092-uftc8inx 1660 11 . . . cord-010092-uftc8inx 1661 1 Descriptive descriptive JJ cord-010092-uftc8inx 1661 2 statistics statistic NNS cord-010092-uftc8inx 1661 3 and and CC cord-010092-uftc8inx 1661 4 comparative comparative JJ cord-010092-uftc8inx 1661 5 analysis analysis NN cord-010092-uftc8inx 1661 6 using use VBG cord-010092-uftc8inx 1661 7 a a DT cord-010092-uftc8inx 1661 8 Pearson Pearson NNP cord-010092-uftc8inx 1661 9 's 's POS cord-010092-uftc8inx 1661 10 Chi Chi NNP cord-010092-uftc8inx 1661 11 - - HYPH cord-010092-uftc8inx 1661 12 Square Square NNP cord-010092-uftc8inx 1661 13 were be VBD cord-010092-uftc8inx 1661 14 used use VBN cord-010092-uftc8inx 1661 15 with with IN cord-010092-uftc8inx 1661 16 a a DT cord-010092-uftc8inx 1661 17 difference difference NN cord-010092-uftc8inx 1661 18 of of IN cord-010092-uftc8inx 1661 19 P p NN cord-010092-uftc8inx 1661 20 < < XX cord-010092-uftc8inx 1661 21 0.05 0.05 CD cord-010092-uftc8inx 1661 22 considered consider VBN cord-010092-uftc8inx 1661 23 statistically statistically RB cord-010092-uftc8inx 1661 24 significant significant JJ cord-010092-uftc8inx 1661 25 . . . cord-010092-uftc8inx 1662 1 Results result NNS cord-010092-uftc8inx 1662 2 : : : cord-010092-uftc8inx 1663 1 There there EX cord-010092-uftc8inx 1663 2 were be VBD cord-010092-uftc8inx 1663 3 1446 1446 CD cord-010092-uftc8inx 1663 4 platelet platelet NN cord-010092-uftc8inx 1663 5 doses dose NNS cord-010092-uftc8inx 1663 6 requiring require VBG cord-010092-uftc8inx 1663 7 approval approval NN cord-010092-uftc8inx 1663 8 with with IN cord-010092-uftc8inx 1663 9 670 670 CD cord-010092-uftc8inx 1663 10 ( ( -LRB- cord-010092-uftc8inx 1663 11 46 46 CD cord-010092-uftc8inx 1663 12 % % NN cord-010092-uftc8inx 1663 13 ) ) -RRB- cord-010092-uftc8inx 1663 14 routed route VBD cord-010092-uftc8inx 1663 15 to to IN cord-010092-uftc8inx 1663 16 the the DT cord-010092-uftc8inx 1663 17 PGY1 PGY1 NNP cord-010092-uftc8inx 1663 18 group group NN cord-010092-uftc8inx 1663 19 and and CC cord-010092-uftc8inx 1663 20 776 776 CD cord-010092-uftc8inx 1663 21 ( ( -LRB- cord-010092-uftc8inx 1663 22 54 54 CD cord-010092-uftc8inx 1663 23 % % NN cord-010092-uftc8inx 1663 24 ) ) -RRB- cord-010092-uftc8inx 1663 25 to to IN cord-010092-uftc8inx 1663 26 the the DT cord-010092-uftc8inx 1663 27 PGY PGY NNP cord-010092-uftc8inx 1663 28 > > SYM cord-010092-uftc8inx 1663 29 1 1 CD cord-010092-uftc8inx 1663 30 group group NN cord-010092-uftc8inx 1663 31 . . . cord-010092-uftc8inx 1664 1 There there EX cord-010092-uftc8inx 1664 2 were be VBD cord-010092-uftc8inx 1664 3 847 847 CD cord-010092-uftc8inx 1664 4 ( ( -LRB- cord-010092-uftc8inx 1664 5 59 59 CD cord-010092-uftc8inx 1664 6 % % NN cord-010092-uftc8inx 1664 7 ) ) -RRB- cord-010092-uftc8inx 1664 8 ordered order VBN cord-010092-uftc8inx 1664 9 doses dose NNS cord-010092-uftc8inx 1664 10 that that WDT cord-010092-uftc8inx 1664 11 were be VBD cord-010092-uftc8inx 1664 12 in in IN cord-010092-uftc8inx 1664 13 compliance compliance NN cord-010092-uftc8inx 1664 14 with with IN cord-010092-uftc8inx 1664 15 hospital hospital NN cord-010092-uftc8inx 1664 16 transfusion transfusion NN cord-010092-uftc8inx 1664 17 policy policy NN cord-010092-uftc8inx 1664 18 and and CC cord-010092-uftc8inx 1664 19 599 599 CD cord-010092-uftc8inx 1664 20 ( ( -LRB- cord-010092-uftc8inx 1664 21 41 41 CD cord-010092-uftc8inx 1664 22 % % NN cord-010092-uftc8inx 1664 23 ) ) -RRB- cord-010092-uftc8inx 1664 24 that that WDT cord-010092-uftc8inx 1664 25 were be VBD cord-010092-uftc8inx 1664 26 not not RB cord-010092-uftc8inx 1664 27 in in IN cord-010092-uftc8inx 1664 28 compliance compliance NN cord-010092-uftc8inx 1664 29 with with IN cord-010092-uftc8inx 1664 30 hospital hospital NN cord-010092-uftc8inx 1664 31 policy policy NN cord-010092-uftc8inx 1664 32 . . . cord-010092-uftc8inx 1665 1 Of of IN cord-010092-uftc8inx 1665 2 the the DT cord-010092-uftc8inx 1665 3 847 847 CD cord-010092-uftc8inx 1665 4 appropriately appropriately RB cord-010092-uftc8inx 1665 5 ordered order VBN cord-010092-uftc8inx 1665 6 doses dose NNS cord-010092-uftc8inx 1665 7 , , , cord-010092-uftc8inx 1665 8 the the DT cord-010092-uftc8inx 1665 9 PGY1 PGY1 NNP cord-010092-uftc8inx 1665 10 group group NN cord-010092-uftc8inx 1665 11 declined decline VBD cord-010092-uftc8inx 1665 12 release release NN cord-010092-uftc8inx 1665 13 of of IN cord-010092-uftc8inx 1665 14 7 7 CD cord-010092-uftc8inx 1665 15 necessitating necessitate VBG cord-010092-uftc8inx 1665 16 the the DT cord-010092-uftc8inx 1665 17 clinical clinical JJ cord-010092-uftc8inx 1665 18 team team NN cord-010092-uftc8inx 1665 19 to to TO cord-010092-uftc8inx 1665 20 insist insist VB cord-010092-uftc8inx 1665 21 upon upon IN cord-010092-uftc8inx 1665 22 release release NN cord-010092-uftc8inx 1665 23 without without IN cord-010092-uftc8inx 1665 24 approval approval NN cord-010092-uftc8inx 1665 25 , , , cord-010092-uftc8inx 1665 26 and and CC cord-010092-uftc8inx 1665 27 there there EX cord-010092-uftc8inx 1665 28 were be VBD cord-010092-uftc8inx 1665 29 zero zero CD cord-010092-uftc8inx 1665 30 such such JJ cord-010092-uftc8inx 1665 31 instances instance NNS cord-010092-uftc8inx 1665 32 in in IN cord-010092-uftc8inx 1665 33 the the DT cord-010092-uftc8inx 1665 34 PGY PGY NNP cord-010092-uftc8inx 1665 35 > > SYM cord-010092-uftc8inx 1665 36 1 1 CD cord-010092-uftc8inx 1665 37 group group NN cord-010092-uftc8inx 1665 38 . . . cord-010092-uftc8inx 1666 1 When when WRB cord-010092-uftc8inx 1666 2 paged page VBN cord-010092-uftc8inx 1666 3 by by IN cord-010092-uftc8inx 1666 4 the the DT cord-010092-uftc8inx 1666 5 blood blood NN cord-010092-uftc8inx 1666 6 bank bank NN cord-010092-uftc8inx 1666 7 , , , cord-010092-uftc8inx 1666 8 PGY1 PGY1 NNP cord-010092-uftc8inx 1666 9 physicians physician NNS cord-010092-uftc8inx 1666 10 approved approve VBD cord-010092-uftc8inx 1666 11 product product NN cord-010092-uftc8inx 1666 12 release release NN cord-010092-uftc8inx 1666 13 not not RB cord-010092-uftc8inx 1666 14 in in IN cord-010092-uftc8inx 1666 15 compliance compliance NN cord-010092-uftc8inx 1666 16 with with IN cord-010092-uftc8inx 1666 17 policy policy NN cord-010092-uftc8inx 1666 18 for for IN cord-010092-uftc8inx 1666 19 191/670 191/670 NNS cord-010092-uftc8inx 1666 20 ( ( -LRB- cord-010092-uftc8inx 1666 21 29 29 CD cord-010092-uftc8inx 1666 22 % % NN cord-010092-uftc8inx 1666 23 ) ) -RRB- cord-010092-uftc8inx 1666 24 doses dose NNS cord-010092-uftc8inx 1666 25 while while IN cord-010092-uftc8inx 1666 26 PGY PGY NNP cord-010092-uftc8inx 1666 27 > > XX cord-010092-uftc8inx 1666 28 1 1 CD cord-010092-uftc8inx 1666 29 physicians physician NNS cord-010092-uftc8inx 1666 30 approved approve VBN cord-010092-uftc8inx 1666 31 not not RB cord-010092-uftc8inx 1666 32 indicated indicate VBD cord-010092-uftc8inx 1666 33 products product NNS cord-010092-uftc8inx 1666 34 for for IN cord-010092-uftc8inx 1666 35 79/776 79/776 CD cord-010092-uftc8inx 1666 36 ( ( -LRB- cord-010092-uftc8inx 1666 37 10 10 CD cord-010092-uftc8inx 1666 38 % % NN cord-010092-uftc8inx 1666 39 ) ) -RRB- cord-010092-uftc8inx 1666 40 of of IN cord-010092-uftc8inx 1666 41 doses dose NNS cord-010092-uftc8inx 1666 42 ( ( -LRB- cord-010092-uftc8inx 1666 43 P p NN cord-010092-uftc8inx 1666 44 < < XX cord-010092-uftc8inx 1666 45 0.01 0.01 CD cord-010092-uftc8inx 1666 46 ) ) -RRB- cord-010092-uftc8inx 1666 47 . . . cord-010092-uftc8inx 1667 1 Products product NNS cord-010092-uftc8inx 1667 2 not not RB cord-010092-uftc8inx 1667 3 indicated indicate VBN cord-010092-uftc8inx 1667 4 by by IN cord-010092-uftc8inx 1667 5 hospital hospital NN cord-010092-uftc8inx 1667 6 policy policy NN cord-010092-uftc8inx 1667 7 were be VBD cord-010092-uftc8inx 1667 8 held hold VBN cord-010092-uftc8inx 1667 9 from from IN cord-010092-uftc8inx 1667 10 release release NN cord-010092-uftc8inx 1667 11 by by IN cord-010092-uftc8inx 1667 12 PGY1 PGY1 NNP cord-010092-uftc8inx 1667 13 physicians physician NNS cord-010092-uftc8inx 1667 14 for for IN cord-010092-uftc8inx 1667 15 113/670 113/670 CD cord-010092-uftc8inx 1667 16 ( ( -LRB- cord-010092-uftc8inx 1667 17 17 17 CD cord-010092-uftc8inx 1667 18 % % NN cord-010092-uftc8inx 1667 19 ) ) -RRB- cord-010092-uftc8inx 1668 1 doses dose NNS cord-010092-uftc8inx 1668 2 and and CC cord-010092-uftc8inx 1668 3 216/776 216/776 CD cord-010092-uftc8inx 1668 4 ( ( -LRB- cord-010092-uftc8inx 1668 5 28 28 CD cord-010092-uftc8inx 1668 6 % % NN cord-010092-uftc8inx 1668 7 ) ) -RRB- cord-010092-uftc8inx 1668 8 doses dose NNS cord-010092-uftc8inx 1668 9 by by IN cord-010092-uftc8inx 1668 10 PGY PGY NNP cord-010092-uftc8inx 1669 1 > > XX cord-010092-uftc8inx 1669 2 1 1 CD cord-010092-uftc8inx 1669 3 physicians physician NNS cord-010092-uftc8inx 1669 4 ( ( -LRB- cord-010092-uftc8inx 1669 5 P p NN cord-010092-uftc8inx 1669 6 < < XX cord-010092-uftc8inx 1669 7 0.01 0.01 CD cord-010092-uftc8inx 1669 8 ) ) -RRB- cord-010092-uftc8inx 1669 9 . . . cord-010092-uftc8inx 1670 1 The the DT cord-010092-uftc8inx 1670 2 ordered order VBN cord-010092-uftc8inx 1670 3 doses dose NNS cord-010092-uftc8inx 1670 4 not not RB cord-010092-uftc8inx 1670 5 in in IN cord-010092-uftc8inx 1670 6 compliance compliance NN cord-010092-uftc8inx 1670 7 with with IN cord-010092-uftc8inx 1670 8 hospital hospital NN cord-010092-uftc8inx 1670 9 policy policy NN cord-010092-uftc8inx 1670 10 had have VBD cord-010092-uftc8inx 1670 11 an an DT cord-010092-uftc8inx 1670 12 estimated estimate VBN cord-010092-uftc8inx 1670 13 cost cost NN cord-010092-uftc8inx 1670 14 of of IN cord-010092-uftc8inx 1670 15 $ $ $ cord-010092-uftc8inx 1670 16 299,500 299,500 CD cord-010092-uftc8inx 1670 17 . . . cord-010092-uftc8inx 1671 1 Of of IN cord-010092-uftc8inx 1671 2 this this DT cord-010092-uftc8inx 1671 3 cost cost NN cord-010092-uftc8inx 1671 4 , , , cord-010092-uftc8inx 1671 5 there there EX cord-010092-uftc8inx 1671 6 was be VBD cord-010092-uftc8inx 1671 7 a a DT cord-010092-uftc8inx 1671 8 calculated calculated JJ cord-010092-uftc8inx 1671 9 $ $ $ cord-010092-uftc8inx 1671 10 164,500 164,500 CD cord-010092-uftc8inx 1671 11 savings saving NNS cord-010092-uftc8inx 1671 12 of of IN cord-010092-uftc8inx 1671 13 products product NNS cord-010092-uftc8inx 1671 14 not not RB cord-010092-uftc8inx 1671 15 released release VBN cord-010092-uftc8inx 1671 16 due due IN cord-010092-uftc8inx 1671 17 to to IN cord-010092-uftc8inx 1671 18 prospective prospective JJ cord-010092-uftc8inx 1671 19 auditing auditing NN cord-010092-uftc8inx 1671 20 . . . cord-010092-uftc8inx 1672 1 There there EX cord-010092-uftc8inx 1672 2 was be VBD cord-010092-uftc8inx 1672 3 an an DT cord-010092-uftc8inx 1672 4 additional additional JJ cord-010092-uftc8inx 1672 5 potential potential JJ cord-010092-uftc8inx 1672 6 savings saving NNS cord-010092-uftc8inx 1672 7 of of IN cord-010092-uftc8inx 1672 8 $ $ $ cord-010092-uftc8inx 1672 9 135,000 135,000 CD cord-010092-uftc8inx 1672 10 for for IN cord-010092-uftc8inx 1672 11 products product NNS cord-010092-uftc8inx 1672 12 not not RB cord-010092-uftc8inx 1672 13 indicated indicate VBN cord-010092-uftc8inx 1672 14 but but CC cord-010092-uftc8inx 1672 15 released release VBN cord-010092-uftc8inx 1672 16 ( ( -LRB- cord-010092-uftc8inx 1672 17 $ $ $ cord-010092-uftc8inx 1672 18 95,500 95,500 CD cord-010092-uftc8inx 1672 19 from from IN cord-010092-uftc8inx 1672 20 the the DT cord-010092-uftc8inx 1672 21 PGY1 PGY1 NNP cord-010092-uftc8inx 1672 22 and and CC cord-010092-uftc8inx 1672 23 $ $ $ cord-010092-uftc8inx 1672 24 39,500 39,500 CD cord-010092-uftc8inx 1672 25 from from IN cord-010092-uftc8inx 1672 26 the the DT cord-010092-uftc8inx 1672 27 PGY PGY NNP cord-010092-uftc8inx 1672 28 > > SYM cord-010092-uftc8inx 1672 29 1 1 CD cord-010092-uftc8inx 1672 30 group group NN cord-010092-uftc8inx 1672 31 ) ) -RRB- cord-010092-uftc8inx 1672 32 . . . cord-010092-uftc8inx 1673 1 Summary Summary NNP cord-010092-uftc8inx 1673 2 / / SYM cord-010092-uftc8inx 1673 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 1673 4 : : : cord-010092-uftc8inx 1674 1 Despite despite IN cord-010092-uftc8inx 1674 2 a a DT cord-010092-uftc8inx 1674 3 higher high JJR cord-010092-uftc8inx 1674 4 number number NN cord-010092-uftc8inx 1674 5 of of IN cord-010092-uftc8inx 1674 6 requests request NNS cord-010092-uftc8inx 1674 7 being be VBG cord-010092-uftc8inx 1674 8 routed route VBN cord-010092-uftc8inx 1674 9 to to IN cord-010092-uftc8inx 1674 10 the the DT cord-010092-uftc8inx 1674 11 more more RBR cord-010092-uftc8inx 1674 12 senior senior JJ cord-010092-uftc8inx 1674 13 PGY pgy NN cord-010092-uftc8inx 1674 14 > > SYM cord-010092-uftc8inx 1674 15 1 1 CD cord-010092-uftc8inx 1674 16 group group NN cord-010092-uftc8inx 1674 17 , , , cord-010092-uftc8inx 1674 18 there there EX cord-010092-uftc8inx 1674 19 were be VBD cord-010092-uftc8inx 1674 20 a a DT cord-010092-uftc8inx 1674 21 disproportionately disproportionately RB cord-010092-uftc8inx 1674 22 higher high JJR cord-010092-uftc8inx 1674 23 number number NN cord-010092-uftc8inx 1674 24 of of IN cord-010092-uftc8inx 1674 25 out out IN cord-010092-uftc8inx 1674 26 of of IN cord-010092-uftc8inx 1674 27 compliance compliance NN cord-010092-uftc8inx 1674 28 platelet platelet NN cord-010092-uftc8inx 1674 29 orders order NNS cord-010092-uftc8inx 1674 30 being be VBG cord-010092-uftc8inx 1674 31 released release VBN cord-010092-uftc8inx 1674 32 by by IN cord-010092-uftc8inx 1674 33 the the DT cord-010092-uftc8inx 1674 34 PGY1 PGY1 NNP cord-010092-uftc8inx 1674 35 group group NN cord-010092-uftc8inx 1674 36 in in IN cord-010092-uftc8inx 1674 37 addition addition NN cord-010092-uftc8inx 1674 38 to to IN cord-010092-uftc8inx 1674 39 withholding withhold VBG cord-010092-uftc8inx 1674 40 needed need VBN cord-010092-uftc8inx 1674 41 products product NNS cord-010092-uftc8inx 1674 42 on on IN cord-010092-uftc8inx 1674 43 several several JJ cord-010092-uftc8inx 1674 44 occasions occasion NNS cord-010092-uftc8inx 1674 45 . . . cord-010092-uftc8inx 1675 1 Potential potential JJ cord-010092-uftc8inx 1675 2 mitigation mitigation NN cord-010092-uftc8inx 1675 3 strategies strategy NNS cord-010092-uftc8inx 1675 4 for for IN cord-010092-uftc8inx 1675 5 this this DT cord-010092-uftc8inx 1675 6 could could MD cord-010092-uftc8inx 1675 7 include include VB cord-010092-uftc8inx 1675 8 a a DT cord-010092-uftc8inx 1675 9 closer close JJR cord-010092-uftc8inx 1675 10 level level NN cord-010092-uftc8inx 1675 11 of of IN cord-010092-uftc8inx 1675 12 oversight oversight NN cord-010092-uftc8inx 1675 13 for for IN cord-010092-uftc8inx 1675 14 PGY1 PGY1 NNP cord-010092-uftc8inx 1675 15 physicians physician NNS cord-010092-uftc8inx 1675 16 , , , cord-010092-uftc8inx 1675 17 and and CC cord-010092-uftc8inx 1675 18 the the DT cord-010092-uftc8inx 1675 19 potential potential JJ cord-010092-uftc8inx 1675 20 monetary monetary JJ cord-010092-uftc8inx 1675 21 savings saving NNS cord-010092-uftc8inx 1675 22 could could MD cord-010092-uftc8inx 1675 23 justify justify VB cord-010092-uftc8inx 1675 24 a a DT cord-010092-uftc8inx 1675 25 hiring hire VBG cord-010092-uftc8inx 1675 26 a a DT cord-010092-uftc8inx 1675 27 dedicated dedicated JJ cord-010092-uftc8inx 1675 28 patient patient JJ cord-010092-uftc8inx 1675 29 blood blood NN cord-010092-uftc8inx 1675 30 management management NN cord-010092-uftc8inx 1675 31 team team NN cord-010092-uftc8inx 1675 32 or or CC cord-010092-uftc8inx 1675 33 quality quality NN cord-010092-uftc8inx 1675 34 assurance assurance NN cord-010092-uftc8inx 1675 35 manager manager NN cord-010092-uftc8inx 1675 36 to to TO cord-010092-uftc8inx 1675 37 monitor monitor VB cord-010092-uftc8inx 1675 38 compliance compliance NN cord-010092-uftc8inx 1675 39 and and CC cord-010092-uftc8inx 1675 40 provide provide VB cord-010092-uftc8inx 1675 41 feedback feedback NN cord-010092-uftc8inx 1675 42 to to IN cord-010092-uftc8inx 1675 43 clinicians clinician NNS cord-010092-uftc8inx 1675 44 . . . cord-010092-uftc8inx 1676 1 3D 3d JJ cord-010092-uftc8inx 1676 2 - - HYPH cord-010092-uftc8inx 1676 3 S14 S14 NNP cord-010092-uftc8inx 1676 4 - - HYPH cord-010092-uftc8inx 1676 5 04 04 CD cord-010092-uftc8inx 1677 1 WHAT what WP cord-010092-uftc8inx 1677 2 CAN CAN MD cord-010092-uftc8inx 1677 3 WE we PRP cord-010092-uftc8inx 1677 4 LEARN learn VB cord-010092-uftc8inx 1677 5 FROM from IN cord-010092-uftc8inx 1677 6 HOW how WRB cord-010092-uftc8inx 1677 7 ADVERSE adverse JJ cord-010092-uftc8inx 1677 8 EVENTS event NNS cord-010092-uftc8inx 1677 9 ARE are VBP cord-010092-uftc8inx 1677 10 DETECTED detect VBN cord-010092-uftc8inx 1677 11 ? ? . cord-010092-uftc8inx 1678 1 Norwegian Norwegian NNP cord-010092-uftc8inx 1678 2 Directorate Directorate NNP cord-010092-uftc8inx 1678 3 of of IN cord-010092-uftc8inx 1678 4 Health Health NNP cord-010092-uftc8inx 1678 5 , , , cord-010092-uftc8inx 1678 6 Oslo Oslo NNP cord-010092-uftc8inx 1678 7 , , , cord-010092-uftc8inx 1679 1 Norway Norway NNP cord-010092-uftc8inx 1679 2 Background Background NNP cord-010092-uftc8inx 1679 3 : : : cord-010092-uftc8inx 1680 1 The the DT cord-010092-uftc8inx 1680 2 primary primary JJ cord-010092-uftc8inx 1680 3 aim aim NN cord-010092-uftc8inx 1680 4 of of IN cord-010092-uftc8inx 1680 5 reporting report VBG cord-010092-uftc8inx 1680 6 systems system NNS cord-010092-uftc8inx 1680 7 , , , cord-010092-uftc8inx 1680 8 such such JJ cord-010092-uftc8inx 1680 9 as as IN cord-010092-uftc8inx 1680 10 haemovigilance haemovigilance NNP cord-010092-uftc8inx 1680 11 systems system NNS cord-010092-uftc8inx 1680 12 , , , cord-010092-uftc8inx 1680 13 should should MD cord-010092-uftc8inx 1680 14 be be VB cord-010092-uftc8inx 1680 15 learning learn VBG cord-010092-uftc8inx 1680 16 and and CC cord-010092-uftc8inx 1680 17 improvement improvement NN cord-010092-uftc8inx 1680 18 and and CC cord-010092-uftc8inx 1680 19 to to TO cord-010092-uftc8inx 1680 20 identify identify VB cord-010092-uftc8inx 1680 21 risk risk NN cord-010092-uftc8inx 1680 22 areas area NNS cord-010092-uftc8inx 1680 23 , , , cord-010092-uftc8inx 1680 24 not not RB cord-010092-uftc8inx 1680 25 simply simply RB cord-010092-uftc8inx 1680 26 counting count VBG cord-010092-uftc8inx 1680 27 errors error NNS cord-010092-uftc8inx 1680 28 . . . cord-010092-uftc8inx 1681 1 To to TO cord-010092-uftc8inx 1681 2 understand understand VB cord-010092-uftc8inx 1681 3 and and CC cord-010092-uftc8inx 1681 4 learn learn VB cord-010092-uftc8inx 1681 5 from from IN cord-010092-uftc8inx 1681 6 adverse adverse JJ cord-010092-uftc8inx 1681 7 events event NNS cord-010092-uftc8inx 1681 8 the the DT cord-010092-uftc8inx 1681 9 description description NN cord-010092-uftc8inx 1681 10 of of IN cord-010092-uftc8inx 1681 11 how how WRB cord-010092-uftc8inx 1681 12 , , , cord-010092-uftc8inx 1681 13 where where WRB cord-010092-uftc8inx 1681 14 and and CC cord-010092-uftc8inx 1681 15 why why WRB cord-010092-uftc8inx 1681 16 they -PRON- PRP cord-010092-uftc8inx 1681 17 occur occur VBP cord-010092-uftc8inx 1681 18 , , , cord-010092-uftc8inx 1681 19 and and CC cord-010092-uftc8inx 1681 20 how how WRB cord-010092-uftc8inx 1681 21 they -PRON- PRP cord-010092-uftc8inx 1681 22 are be VBP cord-010092-uftc8inx 1681 23 detected detect VBN cord-010092-uftc8inx 1681 24 , , , cord-010092-uftc8inx 1681 25 is be VBZ cord-010092-uftc8inx 1681 26 important important JJ cord-010092-uftc8inx 1681 27 . . . cord-010092-uftc8inx 1682 1 To to TO cord-010092-uftc8inx 1682 2 support support VB cord-010092-uftc8inx 1682 3 our -PRON- PRP$ cord-010092-uftc8inx 1682 4 understanding understanding NN cord-010092-uftc8inx 1682 5 , , , cord-010092-uftc8inx 1682 6 we -PRON- PRP cord-010092-uftc8inx 1682 7 use use VBP cord-010092-uftc8inx 1682 8 a a DT cord-010092-uftc8inx 1682 9 predetermined predetermine VBN cord-010092-uftc8inx 1682 10 classification classification NN cord-010092-uftc8inx 1682 11 that that WDT cord-010092-uftc8inx 1682 12 is be VBZ cord-010092-uftc8inx 1682 13 required require VBN cord-010092-uftc8inx 1682 14 for for IN cord-010092-uftc8inx 1682 15 reporting report VBG cord-010092-uftc8inx 1682 16 to to IN cord-010092-uftc8inx 1682 17 EU EU NNP cord-010092-uftc8inx 1682 18 , , , cord-010092-uftc8inx 1682 19 supplemented supplement VBN cord-010092-uftc8inx 1682 20 by by IN cord-010092-uftc8inx 1682 21 classification classification NN cord-010092-uftc8inx 1682 22 suggested suggest VBN cord-010092-uftc8inx 1682 23 by by IN cord-010092-uftc8inx 1682 24 IHN IHN NNP cord-010092-uftc8inx 1682 25 , , , cord-010092-uftc8inx 1682 26 WHO who WP cord-010092-uftc8inx 1682 27 and and CC cord-010092-uftc8inx 1682 28 ourselves -PRON- PRP cord-010092-uftc8inx 1682 29 . . . cord-010092-uftc8inx 1683 1 In in IN cord-010092-uftc8inx 1683 2 2015 2015 CD cord-010092-uftc8inx 1683 3 we -PRON- PRP cord-010092-uftc8inx 1683 4 started start VBD cord-010092-uftc8inx 1683 5 asking ask VBG cord-010092-uftc8inx 1683 6 the the DT cord-010092-uftc8inx 1683 7 blood blood NN cord-010092-uftc8inx 1683 8 establishments establishment NNS cord-010092-uftc8inx 1683 9 what what WP cord-010092-uftc8inx 1683 10 steps step NNS cord-010092-uftc8inx 1683 11 they -PRON- PRP cord-010092-uftc8inx 1683 12 would would MD cord-010092-uftc8inx 1683 13 take take VB cord-010092-uftc8inx 1683 14 to to TO cord-010092-uftc8inx 1683 15 prevent prevent VB cord-010092-uftc8inx 1683 16 recurrence recurrence NN cord-010092-uftc8inx 1683 17 of of IN cord-010092-uftc8inx 1683 18 the the DT cord-010092-uftc8inx 1683 19 event event NN cord-010092-uftc8inx 1683 20 , , , cord-010092-uftc8inx 1683 21 and and CC cord-010092-uftc8inx 1683 22 we -PRON- PRP cord-010092-uftc8inx 1683 23 added add VBD cord-010092-uftc8inx 1683 24 a a DT cord-010092-uftc8inx 1683 25 simple simple JJ cord-010092-uftc8inx 1683 26 classification classification NN cord-010092-uftc8inx 1683 27 to to TO cord-010092-uftc8inx 1683 28 tell tell VB cord-010092-uftc8inx 1683 29 how how WRB cord-010092-uftc8inx 1683 30 the the DT cord-010092-uftc8inx 1683 31 adverse adverse JJ cord-010092-uftc8inx 1683 32 event event NN cord-010092-uftc8inx 1683 33 had have VBD cord-010092-uftc8inx 1683 34 been be VBN cord-010092-uftc8inx 1683 35 detected detect VBN cord-010092-uftc8inx 1683 36 . . . cord-010092-uftc8inx 1684 1 Aims aim VBZ cord-010092-uftc8inx 1684 2 : : : cord-010092-uftc8inx 1685 1 This this DT cord-010092-uftc8inx 1685 2 study study NN cord-010092-uftc8inx 1685 3 aims aim VBZ cord-010092-uftc8inx 1685 4 to to TO cord-010092-uftc8inx 1685 5 analyze analyze VB cord-010092-uftc8inx 1685 6 how how WRB cord-010092-uftc8inx 1685 7 different different JJ cord-010092-uftc8inx 1685 8 types type NNS cord-010092-uftc8inx 1685 9 of of IN cord-010092-uftc8inx 1685 10 adverse adverse JJ cord-010092-uftc8inx 1685 11 events event NNS cord-010092-uftc8inx 1685 12 reported report VBN cord-010092-uftc8inx 1685 13 to to IN cord-010092-uftc8inx 1685 14 the the DT cord-010092-uftc8inx 1685 15 haemovigilance haemovigilance NN cord-010092-uftc8inx 1685 16 system system NN cord-010092-uftc8inx 1685 17 were be VBD cord-010092-uftc8inx 1685 18 detected detect VBN cord-010092-uftc8inx 1685 19 , , , cord-010092-uftc8inx 1685 20 whether whether IN cord-010092-uftc8inx 1685 21 the the DT cord-010092-uftc8inx 1685 22 current current JJ cord-010092-uftc8inx 1685 23 quality quality NN cord-010092-uftc8inx 1685 24 management management NN cord-010092-uftc8inx 1685 25 systems system NNS cord-010092-uftc8inx 1685 26 used use VBN cord-010092-uftc8inx 1685 27 in in IN cord-010092-uftc8inx 1685 28 Norwegian norwegian JJ cord-010092-uftc8inx 1685 29 blood blood NN cord-010092-uftc8inx 1685 30 establishments establishment NNS cord-010092-uftc8inx 1685 31 had have VBD cord-010092-uftc8inx 1685 32 effective effective JJ cord-010092-uftc8inx 1685 33 barriers barrier NNS cord-010092-uftc8inx 1685 34 and and CC cord-010092-uftc8inx 1685 35 whether whether IN cord-010092-uftc8inx 1685 36 new new JJ cord-010092-uftc8inx 1685 37 barriers barrier NNS cord-010092-uftc8inx 1685 38 should should MD cord-010092-uftc8inx 1685 39 be be VB cord-010092-uftc8inx 1685 40 considered consider VBN cord-010092-uftc8inx 1685 41 . . . cord-010092-uftc8inx 1686 1 Methods method NNS cord-010092-uftc8inx 1686 2 : : : cord-010092-uftc8inx 1687 1 Adverse adverse JJ cord-010092-uftc8inx 1687 2 events event NNS cord-010092-uftc8inx 1687 3 reported report VBD cord-010092-uftc8inx 1687 4 to to IN cord-010092-uftc8inx 1687 5 the the DT cord-010092-uftc8inx 1687 6 Norwegian norwegian JJ cord-010092-uftc8inx 1687 7 haemovigilance haemovigilance NN cord-010092-uftc8inx 1687 8 system system NN cord-010092-uftc8inx 1687 9 in in IN cord-010092-uftc8inx 1687 10 2017 2017 CD cord-010092-uftc8inx 1687 11 and and CC cord-010092-uftc8inx 1687 12 2018 2018 CD cord-010092-uftc8inx 1687 13 were be VBD cord-010092-uftc8inx 1687 14 analyzed analyze VBN cord-010092-uftc8inx 1687 15 with with IN cord-010092-uftc8inx 1687 16 focus focus NN cord-010092-uftc8inx 1687 17 on on IN cord-010092-uftc8inx 1687 18 how how WRB cord-010092-uftc8inx 1687 19 the the DT cord-010092-uftc8inx 1687 20 adverse adverse JJ cord-010092-uftc8inx 1687 21 event event NN cord-010092-uftc8inx 1687 22 had have VBD cord-010092-uftc8inx 1687 23 been be VBN cord-010092-uftc8inx 1687 24 detected detect VBN cord-010092-uftc8inx 1687 25 . . . cord-010092-uftc8inx 1688 1 In in IN cord-010092-uftc8inx 1688 2 all all DT cord-010092-uftc8inx 1688 3 cases case NNS cord-010092-uftc8inx 1688 4 classification classification NN cord-010092-uftc8inx 1688 5 had have VBD cord-010092-uftc8inx 1688 6 been be VBN cord-010092-uftc8inx 1688 7 performed perform VBN cord-010092-uftc8inx 1688 8 by by IN cord-010092-uftc8inx 1688 9 the the DT cord-010092-uftc8inx 1688 10 reporter reporter NN cord-010092-uftc8inx 1688 11 of of IN cord-010092-uftc8inx 1688 12 adverse adverse JJ cord-010092-uftc8inx 1688 13 events event NNS cord-010092-uftc8inx 1688 14 and and CC cord-010092-uftc8inx 1688 15 were be VBD cord-010092-uftc8inx 1688 16 confirmed confirm VBN cord-010092-uftc8inx 1688 17 , , , cord-010092-uftc8inx 1688 18 or or CC cord-010092-uftc8inx 1688 19 reclassified reclassify VBN cord-010092-uftc8inx 1688 20 if if IN cord-010092-uftc8inx 1688 21 necessary necessary JJ cord-010092-uftc8inx 1688 22 , , , cord-010092-uftc8inx 1688 23 by by IN cord-010092-uftc8inx 1688 24 the the DT cord-010092-uftc8inx 1688 25 haemovigilance haemovigilance NNP cord-010092-uftc8inx 1688 26 team team NN cord-010092-uftc8inx 1688 27 before before IN cord-010092-uftc8inx 1688 28 analysis analysis NN cord-010092-uftc8inx 1688 29 . . . cord-010092-uftc8inx 1689 1 For for IN cord-010092-uftc8inx 1689 2 analysis analysis NN cord-010092-uftc8inx 1689 3 based base VBN cord-010092-uftc8inx 1689 4 on on IN cord-010092-uftc8inx 1689 5 classification classification NN cord-010092-uftc8inx 1689 6 we -PRON- PRP cord-010092-uftc8inx 1689 7 used use VBD cord-010092-uftc8inx 1689 8 PowerBI PowerBI NNS cord-010092-uftc8inx 1689 9 ( ( -LRB- cord-010092-uftc8inx 1689 10 Microsoft Microsoft NNP cord-010092-uftc8inx 1689 11 ) ) -RRB- cord-010092-uftc8inx 1689 12 . . . cord-010092-uftc8inx 1690 1 Results result NNS cord-010092-uftc8inx 1690 2 : : : cord-010092-uftc8inx 1691 1 A a DT cord-010092-uftc8inx 1691 2 total total NN cord-010092-uftc8inx 1691 3 of of IN cord-010092-uftc8inx 1691 4 188 188 CD cord-010092-uftc8inx 1691 5 adverse adverse JJ cord-010092-uftc8inx 1691 6 events event NNS cord-010092-uftc8inx 1691 7 were be VBD cord-010092-uftc8inx 1691 8 reported report VBN cord-010092-uftc8inx 1691 9 from from IN cord-010092-uftc8inx 1691 10 Norwegian norwegian JJ cord-010092-uftc8inx 1691 11 blood blood NN cord-010092-uftc8inx 1691 12 establishments establishment NNS cord-010092-uftc8inx 1691 13 . . . cord-010092-uftc8inx 1692 1 All all DT cord-010092-uftc8inx 1692 2 had have VBD cord-010092-uftc8inx 1692 3 been be VBN cord-010092-uftc8inx 1692 4 classified classify VBN cord-010092-uftc8inx 1692 5 according accord VBG cord-010092-uftc8inx 1692 6 to to IN cord-010092-uftc8inx 1692 7 how how WRB cord-010092-uftc8inx 1692 8 the the DT cord-010092-uftc8inx 1692 9 adverse adverse JJ cord-010092-uftc8inx 1692 10 event event NN cord-010092-uftc8inx 1692 11 had have VBD cord-010092-uftc8inx 1692 12 been be VBN cord-010092-uftc8inx 1692 13 detected detect VBN cord-010092-uftc8inx 1692 14 . . . cord-010092-uftc8inx 1693 1 Twenty twenty CD cord-010092-uftc8inx 1693 2 ( ( -LRB- cord-010092-uftc8inx 1693 3 10.6 10.6 CD cord-010092-uftc8inx 1693 4 % % NN cord-010092-uftc8inx 1693 5 ) ) -RRB- cord-010092-uftc8inx 1694 1 adverse adverse JJ cord-010092-uftc8inx 1694 2 events event NNS cord-010092-uftc8inx 1694 3 were be VBD cord-010092-uftc8inx 1694 4 detected detect VBN cord-010092-uftc8inx 1694 5 because because IN cord-010092-uftc8inx 1694 6 of of IN cord-010092-uftc8inx 1694 7 alarms alarm NNS cord-010092-uftc8inx 1694 8 or or CC cord-010092-uftc8inx 1694 9 warnings warning NNS cord-010092-uftc8inx 1694 10 from from IN cord-010092-uftc8inx 1694 11 IT it NN cord-010092-uftc8inx 1694 12 - - HYPH cord-010092-uftc8inx 1694 13 systems system NNS cord-010092-uftc8inx 1694 14 or or CC cord-010092-uftc8inx 1694 15 equipment equipment NN cord-010092-uftc8inx 1694 16 . . . cord-010092-uftc8inx 1695 1 Routine routine JJ cord-010092-uftc8inx 1695 2 checks check NNS cord-010092-uftc8inx 1695 3 by by IN cord-010092-uftc8inx 1695 4 blood blood NN cord-010092-uftc8inx 1695 5 establishment establishment NN cord-010092-uftc8inx 1695 6 staff staff NN cord-010092-uftc8inx 1695 7 detected detect VBD cord-010092-uftc8inx 1695 8 39 39 CD cord-010092-uftc8inx 1695 9 ( ( -LRB- cord-010092-uftc8inx 1695 10 20.7 20.7 CD cord-010092-uftc8inx 1695 11 % % NN cord-010092-uftc8inx 1695 12 ) ) -RRB- cord-010092-uftc8inx 1695 13 events event NNS cord-010092-uftc8inx 1695 14 and and CC cord-010092-uftc8inx 1695 15 formal formal JJ cord-010092-uftc8inx 1695 16 internal internal JJ cord-010092-uftc8inx 1695 17 or or CC cord-010092-uftc8inx 1695 18 external external JJ cord-010092-uftc8inx 1695 19 reviews review NNS cord-010092-uftc8inx 1695 20 detected detect VBD cord-010092-uftc8inx 1695 21 one one CD cord-010092-uftc8inx 1695 22 event event NN cord-010092-uftc8inx 1695 23 . . . cord-010092-uftc8inx 1696 1 Seven seven CD cord-010092-uftc8inx 1696 2 ( ( -LRB- cord-010092-uftc8inx 1696 3 3.7 3.7 CD cord-010092-uftc8inx 1696 4 % % NN cord-010092-uftc8inx 1696 5 ) ) -RRB- cord-010092-uftc8inx 1696 6 events event NNS cord-010092-uftc8inx 1696 7 were be VBD cord-010092-uftc8inx 1696 8 detected detect VBN cord-010092-uftc8inx 1696 9 because because IN cord-010092-uftc8inx 1696 10 the the DT cord-010092-uftc8inx 1696 11 donor donor NN cord-010092-uftc8inx 1696 12 became become VBD cord-010092-uftc8inx 1696 13 ill ill RB cord-010092-uftc8inx 1696 14 shortly shortly RB cord-010092-uftc8inx 1696 15 after after IN cord-010092-uftc8inx 1696 16 donation donation NN cord-010092-uftc8inx 1696 17 , , , cord-010092-uftc8inx 1696 18 but but CC cord-010092-uftc8inx 1696 19 the the DT cord-010092-uftc8inx 1696 20 illness illness NN cord-010092-uftc8inx 1696 21 was be VBD cord-010092-uftc8inx 1696 22 not not RB cord-010092-uftc8inx 1696 23 caused cause VBN cord-010092-uftc8inx 1696 24 by by IN cord-010092-uftc8inx 1696 25 the the DT cord-010092-uftc8inx 1696 26 donation donation NN cord-010092-uftc8inx 1696 27 . . . cord-010092-uftc8inx 1697 1 Sixty sixty CD cord-010092-uftc8inx 1697 2 - - HYPH cord-010092-uftc8inx 1697 3 four four CD cord-010092-uftc8inx 1697 4 percent percent NN cord-010092-uftc8inx 1697 5 of of IN cord-010092-uftc8inx 1697 6 events event NNS cord-010092-uftc8inx 1697 7 were be VBD cord-010092-uftc8inx 1697 8 detected detect VBN cord-010092-uftc8inx 1697 9 in in IN cord-010092-uftc8inx 1697 10 a a DT cord-010092-uftc8inx 1697 11 way way NN cord-010092-uftc8inx 1697 12 that that WDT cord-010092-uftc8inx 1697 13 did do VBD cord-010092-uftc8inx 1697 14 not not RB cord-010092-uftc8inx 1697 15 fit fit VB cord-010092-uftc8inx 1697 16 our -PRON- PRP$ cord-010092-uftc8inx 1697 17 present present JJ cord-010092-uftc8inx 1697 18 classification classification NN cord-010092-uftc8inx 1697 19 and and CC cord-010092-uftc8inx 1697 20 hence hence RB cord-010092-uftc8inx 1697 21 were be VBD cord-010092-uftc8inx 1697 22 classified classify VBN cord-010092-uftc8inx 1697 23 as as IN cord-010092-uftc8inx 1697 24 " " `` cord-010092-uftc8inx 1697 25 Other other JJ cord-010092-uftc8inx 1697 26 " " '' cord-010092-uftc8inx 1697 27 . . . cord-010092-uftc8inx 1698 1 Twelve twelve CD cord-010092-uftc8inx 1698 2 out out IN cord-010092-uftc8inx 1698 3 of of IN cord-010092-uftc8inx 1698 4 16 16 CD cord-010092-uftc8inx 1698 5 wrong wrong JJ cord-010092-uftc8inx 1698 6 blood blood NN cord-010092-uftc8inx 1698 7 in in IN cord-010092-uftc8inx 1698 8 tube tube NN cord-010092-uftc8inx 1698 9 were be VBD cord-010092-uftc8inx 1698 10 detected detect VBN cord-010092-uftc8inx 1698 11 by by IN cord-010092-uftc8inx 1698 12 an an DT cord-010092-uftc8inx 1698 13 alarm alarm NN cord-010092-uftc8inx 1698 14 from from IN cord-010092-uftc8inx 1698 15 the the DT cord-010092-uftc8inx 1698 16 IT IT NNP cord-010092-uftc8inx 1698 17 - - HYPH cord-010092-uftc8inx 1698 18 system system NN cord-010092-uftc8inx 1698 19 or or CC cord-010092-uftc8inx 1698 20 routine routine JJ cord-010092-uftc8inx 1698 21 check check NN cord-010092-uftc8inx 1698 22 , , , cord-010092-uftc8inx 1698 23 as as IN cord-010092-uftc8inx 1698 24 were be VBD cord-010092-uftc8inx 1698 25 six six CD cord-010092-uftc8inx 1698 26 of of IN cord-010092-uftc8inx 1698 27 22 22 CD cord-010092-uftc8inx 1698 28 events event NNS cord-010092-uftc8inx 1698 29 related relate VBN cord-010092-uftc8inx 1698 30 to to IN cord-010092-uftc8inx 1698 31 blood blood NN cord-010092-uftc8inx 1698 32 ordering ordering NN cord-010092-uftc8inx 1698 33 , , , cord-010092-uftc8inx 1698 34 two two CD cord-010092-uftc8inx 1698 35 of of IN cord-010092-uftc8inx 1698 36 seven seven CD cord-010092-uftc8inx 1698 37 errors error NNS cord-010092-uftc8inx 1698 38 in in IN cord-010092-uftc8inx 1698 39 testing testing NN cord-010092-uftc8inx 1698 40 , , , cord-010092-uftc8inx 1698 41 six six CD cord-010092-uftc8inx 1698 42 of of IN cord-010092-uftc8inx 1698 43 17 17 CD cord-010092-uftc8inx 1698 44 events event NNS cord-010092-uftc8inx 1698 45 where where WRB cord-010092-uftc8inx 1698 46 incorrect incorrect JJ cord-010092-uftc8inx 1698 47 blood blood NN cord-010092-uftc8inx 1698 48 had have VBD cord-010092-uftc8inx 1698 49 been be VBN cord-010092-uftc8inx 1698 50 transfused transfuse VBN cord-010092-uftc8inx 1698 51 , , , cord-010092-uftc8inx 1698 52 and and CC cord-010092-uftc8inx 1698 53 eight eight CD cord-010092-uftc8inx 1698 54 of of IN cord-010092-uftc8inx 1698 55 64 64 CD cord-010092-uftc8inx 1698 56 events event NNS cord-010092-uftc8inx 1698 57 related relate VBN cord-010092-uftc8inx 1698 58 to to IN cord-010092-uftc8inx 1698 59 donor donor NN cord-010092-uftc8inx 1698 60 selection selection NN cord-010092-uftc8inx 1698 61 . . . cord-010092-uftc8inx 1699 1 In in IN cord-010092-uftc8inx 1699 2 80 80 CD cord-010092-uftc8inx 1699 3 reports report NNS cord-010092-uftc8inx 1699 4 human human JJ cord-010092-uftc8inx 1699 5 error error NN cord-010092-uftc8inx 1699 6 was be VBD cord-010092-uftc8inx 1699 7 listed list VBN cord-010092-uftc8inx 1699 8 as as IN cord-010092-uftc8inx 1699 9 the the DT cord-010092-uftc8inx 1699 10 cause cause NN cord-010092-uftc8inx 1699 11 of of IN cord-010092-uftc8inx 1699 12 the the DT cord-010092-uftc8inx 1699 13 event event NN cord-010092-uftc8inx 1699 14 and and CC cord-010092-uftc8inx 1699 15 27 27 CD cord-010092-uftc8inx 1699 16 of of IN cord-010092-uftc8inx 1699 17 these these DT cord-010092-uftc8inx 1699 18 were be VBD cord-010092-uftc8inx 1699 19 detected detect VBN cord-010092-uftc8inx 1699 20 by by IN cord-010092-uftc8inx 1699 21 alarms alarm NNS cord-010092-uftc8inx 1699 22 or or CC cord-010092-uftc8inx 1699 23 routine routine JJ cord-010092-uftc8inx 1699 24 checks check NNS cord-010092-uftc8inx 1699 25 . . . cord-010092-uftc8inx 1700 1 Summary Summary NNP cord-010092-uftc8inx 1700 2 / / SYM cord-010092-uftc8inx 1700 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 1700 4 : : : cord-010092-uftc8inx 1701 1 Detection detection NN cord-010092-uftc8inx 1701 2 of of IN cord-010092-uftc8inx 1701 3 adverse adverse JJ cord-010092-uftc8inx 1701 4 events event NNS cord-010092-uftc8inx 1701 5 by by IN cord-010092-uftc8inx 1701 6 alarms alarm NNS cord-010092-uftc8inx 1701 7 or or CC cord-010092-uftc8inx 1701 8 routine routine JJ cord-010092-uftc8inx 1701 9 checks check NNS cord-010092-uftc8inx 1701 10 are be VBP cord-010092-uftc8inx 1701 11 highly highly RB cord-010092-uftc8inx 1701 12 efficient efficient JJ cord-010092-uftc8inx 1701 13 when when WRB cord-010092-uftc8inx 1701 14 the the DT cord-010092-uftc8inx 1701 15 blood blood NN cord-010092-uftc8inx 1701 16 establishment establishment NN cord-010092-uftc8inx 1701 17 has have VBZ cord-010092-uftc8inx 1701 18 historic historic JJ cord-010092-uftc8inx 1701 19 data datum NNS cord-010092-uftc8inx 1701 20 to to TO cord-010092-uftc8inx 1701 21 check check VB cord-010092-uftc8inx 1701 22 against against IN cord-010092-uftc8inx 1701 23 , , , cord-010092-uftc8inx 1701 24 as as IN cord-010092-uftc8inx 1701 25 exemplified exemplify VBN cord-010092-uftc8inx 1701 26 with with IN cord-010092-uftc8inx 1701 27 wrong wrong JJ cord-010092-uftc8inx 1701 28 blood blood NN cord-010092-uftc8inx 1701 29 in in IN cord-010092-uftc8inx 1701 30 tube tube NN cord-010092-uftc8inx 1701 31 or or CC cord-010092-uftc8inx 1701 32 a a DT cord-010092-uftc8inx 1701 33 patient patient NN cord-010092-uftc8inx 1702 1 require require VB cord-010092-uftc8inx 1702 2 irradiated irradiated JJ cord-010092-uftc8inx 1702 3 blood blood NN cord-010092-uftc8inx 1702 4 components component NNS cord-010092-uftc8inx 1702 5 . . . cord-010092-uftc8inx 1703 1 When when WRB cord-010092-uftc8inx 1703 2 no no DT cord-010092-uftc8inx 1703 3 historical historical JJ cord-010092-uftc8inx 1703 4 data data NN cord-010092-uftc8inx 1703 5 exists exist VBZ cord-010092-uftc8inx 1703 6 or or CC cord-010092-uftc8inx 1703 7 when when WRB cord-010092-uftc8inx 1703 8 the the DT cord-010092-uftc8inx 1703 9 quality quality NN cord-010092-uftc8inx 1703 10 management management NN cord-010092-uftc8inx 1703 11 systems system NNS cord-010092-uftc8inx 1703 12 do do VBP cord-010092-uftc8inx 1703 13 not not RB cord-010092-uftc8inx 1703 14 require require VB cord-010092-uftc8inx 1703 15 routine routine JJ cord-010092-uftc8inx 1703 16 checks check NNS cord-010092-uftc8inx 1703 17 , , , cord-010092-uftc8inx 1703 18 events event NNS cord-010092-uftc8inx 1703 19 are be VBP cord-010092-uftc8inx 1703 20 usually usually RB cord-010092-uftc8inx 1703 21 detected detect VBN cord-010092-uftc8inx 1703 22 by by IN cord-010092-uftc8inx 1703 23 chance chance NN cord-010092-uftc8inx 1703 24 . . . cord-010092-uftc8inx 1704 1 Further further JJ cord-010092-uftc8inx 1704 2 analysis analysis NN cord-010092-uftc8inx 1704 3 is be VBZ cord-010092-uftc8inx 1704 4 needed need VBN cord-010092-uftc8inx 1704 5 to to TO cord-010092-uftc8inx 1704 6 see see VB cord-010092-uftc8inx 1704 7 if if IN cord-010092-uftc8inx 1704 8 and and CC cord-010092-uftc8inx 1704 9 where where WRB cord-010092-uftc8inx 1704 10 the the DT cord-010092-uftc8inx 1704 11 quality quality NN cord-010092-uftc8inx 1704 12 management management NN cord-010092-uftc8inx 1704 13 systems system NNS cord-010092-uftc8inx 1704 14 should should MD cord-010092-uftc8inx 1704 15 be be VB cord-010092-uftc8inx 1704 16 improved improve VBN cord-010092-uftc8inx 1704 17 . . . cord-010092-uftc8inx 1705 1 The the DT cord-010092-uftc8inx 1705 2 wide wide JJ cord-010092-uftc8inx 1705 3 variety variety NN cord-010092-uftc8inx 1705 4 of of IN cord-010092-uftc8inx 1705 5 adverse adverse JJ cord-010092-uftc8inx 1705 6 events event NNS cord-010092-uftc8inx 1705 7 can can MD cord-010092-uftc8inx 1705 8 make make VB cord-010092-uftc8inx 1705 9 it -PRON- PRP cord-010092-uftc8inx 1705 10 difficult difficult JJ cord-010092-uftc8inx 1705 11 to to TO cord-010092-uftc8inx 1705 12 select select VB cord-010092-uftc8inx 1705 13 which which WDT cord-010092-uftc8inx 1705 14 area area NN cord-010092-uftc8inx 1705 15 to to TO cord-010092-uftc8inx 1705 16 prioritize prioritize VB cord-010092-uftc8inx 1705 17 in in IN cord-010092-uftc8inx 1705 18 the the DT cord-010092-uftc8inx 1705 19 improvement improvement NN cord-010092-uftc8inx 1705 20 work work NN cord-010092-uftc8inx 1705 21 . . . cord-010092-uftc8inx 1706 1 Results result NNS cord-010092-uftc8inx 1706 2 : : : cord-010092-uftc8inx 1707 1 The the DT cord-010092-uftc8inx 1707 2 Hb Hb NNP cord-010092-uftc8inx 1707 3 measurements measurement NNS cord-010092-uftc8inx 1707 4 from from IN cord-010092-uftc8inx 1707 5 the the DT cord-010092-uftc8inx 1707 6 finger finger NN cord-010092-uftc8inx 1707 7 prick prick NN cord-010092-uftc8inx 1707 8 were be VBD cord-010092-uftc8inx 1707 9 on on IN cord-010092-uftc8inx 1707 10 average average JJ cord-010092-uftc8inx 1707 11 1.2 1.2 CD cord-010092-uftc8inx 1707 12 g g NN cord-010092-uftc8inx 1707 13 / / SYM cord-010092-uftc8inx 1707 14 L l NN cord-010092-uftc8inx 1707 15 ( ( -LRB- cord-010092-uftc8inx 1707 16 0.9 0.9 CD cord-010092-uftc8inx 1707 17 % % NN cord-010092-uftc8inx 1707 18 ) ) -RRB- cord-010092-uftc8inx 1707 19 higher high JJR cord-010092-uftc8inx 1707 20 than than IN cord-010092-uftc8inx 1707 21 from from IN cord-010092-uftc8inx 1707 22 the the DT cord-010092-uftc8inx 1707 23 venous venous JJ cord-010092-uftc8inx 1707 24 blood blood NN cord-010092-uftc8inx 1707 25 samples sample NNS cord-010092-uftc8inx 1707 26 . . . cord-010092-uftc8inx 1708 1 The the DT cord-010092-uftc8inx 1708 2 range range NN cord-010092-uftc8inx 1708 3 of of IN cord-010092-uftc8inx 1708 4 the the DT cord-010092-uftc8inx 1708 5 difference difference NN cord-010092-uftc8inx 1708 6 was be VBD cord-010092-uftc8inx 1708 7 -21 -21 . cord-010092-uftc8inx 1709 1 -+22 -+22 NNP cord-010092-uftc8inx 1709 2 g g NNP cord-010092-uftc8inx 1709 3 / / SYM cord-010092-uftc8inx 1709 4 L. L. NNP cord-010092-uftc8inx 1710 1 These these DT cord-010092-uftc8inx 1710 2 results result NNS cord-010092-uftc8inx 1710 3 were be VBD cord-010092-uftc8inx 1710 4 used use VBN cord-010092-uftc8inx 1710 5 in in IN cord-010092-uftc8inx 1710 6 order order NN cord-010092-uftc8inx 1710 7 to to TO cord-010092-uftc8inx 1710 8 add add VB cord-010092-uftc8inx 1710 9 novel novel JJ cord-010092-uftc8inx 1710 10 information information NN cord-010092-uftc8inx 1710 11 to to TO cord-010092-uftc8inx 1710 12 determine determine VB cord-010092-uftc8inx 1710 13 the the DT cord-010092-uftc8inx 1710 14 measuring measure VBG cord-010092-uftc8inx 1710 15 uncertainty uncertainty NN cord-010092-uftc8inx 1710 16 of of IN cord-010092-uftc8inx 1710 17 Hb Hb NNP cord-010092-uftc8inx 1710 18 measurement measurement NN cord-010092-uftc8inx 1710 19 in in IN cord-010092-uftc8inx 1710 20 FRCBS FRCBS NNP cord-010092-uftc8inx 1710 21 . . . cord-010092-uftc8inx 1711 1 In in IN cord-010092-uftc8inx 1711 2 1.4 1.4 CD cord-010092-uftc8inx 1711 3 % % NN cord-010092-uftc8inx 1711 4 ( ( -LRB- cord-010092-uftc8inx 1711 5 12/845 12/845 CD cord-010092-uftc8inx 1711 6 ) ) -RRB- cord-010092-uftc8inx 1711 7 of of IN cord-010092-uftc8inx 1711 8 the the DT cord-010092-uftc8inx 1711 9 donors donor NNS cord-010092-uftc8inx 1711 10 in in IN cord-010092-uftc8inx 1711 11 this this DT cord-010092-uftc8inx 1711 12 study study NN cord-010092-uftc8inx 1711 13 the the DT cord-010092-uftc8inx 1711 14 venous venous JJ cord-010092-uftc8inx 1711 15 hemoglobin hemoglobin NN cord-010092-uftc8inx 1711 16 measurements measurement NNS cord-010092-uftc8inx 1711 17 were be VBD cord-010092-uftc8inx 1711 18 below below IN cord-010092-uftc8inx 1711 19 the the DT cord-010092-uftc8inx 1711 20 cut cut VB cord-010092-uftc8inx 1711 21 - - HYPH cord-010092-uftc8inx 1711 22 off off RP cord-010092-uftc8inx 1711 23 point point NN cord-010092-uftc8inx 1711 24 of of IN cord-010092-uftc8inx 1711 25 donor donor NN cord-010092-uftc8inx 1711 26 eligibility eligibility NN cord-010092-uftc8inx 1711 27 . . . cord-010092-uftc8inx 1712 1 In in IN cord-010092-uftc8inx 1712 2 those those DT cord-010092-uftc8inx 1712 3 measurements measurement NNS cord-010092-uftc8inx 1712 4 the the DT cord-010092-uftc8inx 1712 5 difference difference NN cord-010092-uftc8inx 1712 6 of of IN cord-010092-uftc8inx 1712 7 the the DT cord-010092-uftc8inx 1712 8 finger finger NN cord-010092-uftc8inx 1712 9 prick prick NN cord-010092-uftc8inx 1712 10 and and CC cord-010092-uftc8inx 1712 11 venous venous JJ cord-010092-uftc8inx 1712 12 hemoglobin hemoglobin NN cord-010092-uftc8inx 1712 13 measurement measurement NN cord-010092-uftc8inx 1712 14 was be VBD cord-010092-uftc8inx 1712 15 at at IN cord-010092-uftc8inx 1712 16 most most JJS cord-010092-uftc8inx 1712 17 + + . cord-010092-uftc8inx 1713 1 9 9 CD cord-010092-uftc8inx 1713 2 g g NN cord-010092-uftc8inx 1713 3 / / SYM cord-010092-uftc8inx 1713 4 L. L. NNP cord-010092-uftc8inx 1713 5 92 92 CD cord-010092-uftc8inx 1713 6 % % NN cord-010092-uftc8inx 1713 7 of of IN cord-010092-uftc8inx 1713 8 the the DT cord-010092-uftc8inx 1713 9 hemoglobin hemoglobin NN cord-010092-uftc8inx 1713 10 results result NNS cord-010092-uftc8inx 1713 11 from from IN cord-010092-uftc8inx 1713 12 the the DT cord-010092-uftc8inx 1713 13 finger finger NN cord-010092-uftc8inx 1713 14 prick prick NN cord-010092-uftc8inx 1713 15 were be VBD cord-010092-uftc8inx 1713 16 in in IN cord-010092-uftc8inx 1713 17 the the DT cord-010092-uftc8inx 1713 18 range range NN cord-010092-uftc8inx 1713 19 AE10 AE10 NNP cord-010092-uftc8inx 1713 20 g g NNP cord-010092-uftc8inx 1713 21 / / SYM cord-010092-uftc8inx 1713 22 L l NN cord-010092-uftc8inx 1713 23 compared compare VBN cord-010092-uftc8inx 1713 24 to to IN cord-010092-uftc8inx 1713 25 the the DT cord-010092-uftc8inx 1713 26 venous venous JJ cord-010092-uftc8inx 1713 27 hemoglobin hemoglobin NN cord-010092-uftc8inx 1713 28 results result NNS cord-010092-uftc8inx 1713 29 . . . cord-010092-uftc8inx 1714 1 63 63 CD cord-010092-uftc8inx 1714 2 % % NN cord-010092-uftc8inx 1714 3 of of IN cord-010092-uftc8inx 1714 4 the the DT cord-010092-uftc8inx 1714 5 results result NNS cord-010092-uftc8inx 1714 6 from from IN cord-010092-uftc8inx 1714 7 the the DT cord-010092-uftc8inx 1714 8 finger finger NN cord-010092-uftc8inx 1714 9 prick prick NN cord-010092-uftc8inx 1714 10 were be VBD cord-010092-uftc8inx 1714 11 between between IN cord-010092-uftc8inx 1714 12 AE5 AE5 NNP cord-010092-uftc8inx 1714 13 g g NNP cord-010092-uftc8inx 1714 14 / / SYM cord-010092-uftc8inx 1714 15 L L NNP cord-010092-uftc8inx 1714 16 ( ( -LRB- cord-010092-uftc8inx 1714 17 the the DT cord-010092-uftc8inx 1714 18 precision precision NN cord-010092-uftc8inx 1714 19 of of IN cord-010092-uftc8inx 1714 20 the the DT cord-010092-uftc8inx 1714 21 device device NN cord-010092-uftc8inx 1714 22 ) ) -RRB- cord-010092-uftc8inx 1714 23 compared compare VBN cord-010092-uftc8inx 1714 24 to to IN cord-010092-uftc8inx 1714 25 venous venous JJ cord-010092-uftc8inx 1714 26 hemoglobin hemoglobin NN cord-010092-uftc8inx 1714 27 results result NNS cord-010092-uftc8inx 1714 28 . . . cord-010092-uftc8inx 1715 1 In in IN cord-010092-uftc8inx 1715 2 13 13 CD cord-010092-uftc8inx 1715 3 cases case NNS cord-010092-uftc8inx 1715 4 the the DT cord-010092-uftc8inx 1715 5 difference difference NN cord-010092-uftc8inx 1715 6 between between IN cord-010092-uftc8inx 1715 7 finger finger NN cord-010092-uftc8inx 1715 8 prick prick NN cord-010092-uftc8inx 1715 9 and and CC cord-010092-uftc8inx 1715 10 venous venous JJ cord-010092-uftc8inx 1715 11 measurements measurement NNS cord-010092-uftc8inx 1715 12 was be VBD cord-010092-uftc8inx 1715 13 outside outside IN cord-010092-uftc8inx 1715 14 2 2 CD cord-010092-uftc8inx 1715 15 standard standard JJ cord-010092-uftc8inx 1715 16 deviations deviation NNS cord-010092-uftc8inx 1715 17 from from IN cord-010092-uftc8inx 1715 18 the the DT cord-010092-uftc8inx 1715 19 mean mean NN cord-010092-uftc8inx 1715 20 i.e. i.e. FW cord-010092-uftc8inx 1715 21 2.5 2.5 CD cord-010092-uftc8inx 1715 22 % % NN cord-010092-uftc8inx 1715 23 from from IN cord-010092-uftc8inx 1715 24 the the DT cord-010092-uftc8inx 1715 25 bottom bottom NN cord-010092-uftc8inx 1715 26 ( ( -LRB- cord-010092-uftc8inx 1715 27 n n NN cord-010092-uftc8inx 1715 28 = = SYM cord-010092-uftc8inx 1715 29 9 9 CD cord-010092-uftc8inx 1715 30 ) ) -RRB- cord-010092-uftc8inx 1715 31 or or CC cord-010092-uftc8inx 1715 32 top top NN cord-010092-uftc8inx 1715 33 ( ( -LRB- cord-010092-uftc8inx 1715 34 n n NN cord-010092-uftc8inx 1715 35 = = SYM cord-010092-uftc8inx 1715 36 4 4 CD cord-010092-uftc8inx 1715 37 ) ) -RRB- cord-010092-uftc8inx 1715 38 of of IN cord-010092-uftc8inx 1715 39 distribution distribution NN cord-010092-uftc8inx 1715 40 . . . cord-010092-uftc8inx 1716 1 Systematic systematic JJ cord-010092-uftc8inx 1716 2 errors error NNS cord-010092-uftc8inx 1716 3 were be VBD cord-010092-uftc8inx 1716 4 seen see VBN cord-010092-uftc8inx 1716 5 in in IN cord-010092-uftc8inx 1716 6 some some DT cord-010092-uftc8inx 1716 7 nurse nurse NN cord-010092-uftc8inx 1716 8 's 's POS cord-010092-uftc8inx 1716 9 results result NNS cord-010092-uftc8inx 1716 10 both both DT cord-010092-uftc8inx 1716 11 towards towards IN cord-010092-uftc8inx 1716 12 too too RB cord-010092-uftc8inx 1716 13 low low JJ cord-010092-uftc8inx 1716 14 or or CC cord-010092-uftc8inx 1716 15 too too RB cord-010092-uftc8inx 1716 16 high high JJ cord-010092-uftc8inx 1716 17 Hb Hb NNP cord-010092-uftc8inx 1716 18 result result NN cord-010092-uftc8inx 1716 19 in in IN cord-010092-uftc8inx 1716 20 the the DT cord-010092-uftc8inx 1716 21 finger finger NN cord-010092-uftc8inx 1716 22 prick prick NN cord-010092-uftc8inx 1716 23 measurement measurement NN cord-010092-uftc8inx 1716 24 and and CC cord-010092-uftc8inx 1716 25 some some DT cord-010092-uftc8inx 1716 26 nurses nurse NNS cord-010092-uftc8inx 1716 27 had have VBD cord-010092-uftc8inx 1716 28 random random JJ cord-010092-uftc8inx 1716 29 errors error NNS cord-010092-uftc8inx 1716 30 in in IN cord-010092-uftc8inx 1716 31 both both DT cord-010092-uftc8inx 1716 32 directions direction NNS cord-010092-uftc8inx 1716 33 . . . cord-010092-uftc8inx 1717 1 The the DT cord-010092-uftc8inx 1717 2 batch batch NN cord-010092-uftc8inx 1717 3 of of IN cord-010092-uftc8inx 1717 4 cuvettes cuvette NNS cord-010092-uftc8inx 1717 5 , , , cord-010092-uftc8inx 1717 6 donors donor NNS cord-010092-uftc8inx 1717 7 ' ' POS cord-010092-uftc8inx 1717 8 age age NN cord-010092-uftc8inx 1717 9 , , , cord-010092-uftc8inx 1717 10 gender gender NN cord-010092-uftc8inx 1717 11 or or CC cord-010092-uftc8inx 1717 12 the the DT cord-010092-uftc8inx 1717 13 time time NN cord-010092-uftc8inx 1717 14 of of IN cord-010092-uftc8inx 1717 15 sampling sampling NN cord-010092-uftc8inx 1717 16 were be VBD cord-010092-uftc8inx 1717 17 not not RB cord-010092-uftc8inx 1717 18 detected detect VBN cord-010092-uftc8inx 1717 19 to to TO cord-010092-uftc8inx 1717 20 have have VB cord-010092-uftc8inx 1717 21 an an DT cord-010092-uftc8inx 1717 22 impact impact NN cord-010092-uftc8inx 1717 23 on on IN cord-010092-uftc8inx 1717 24 the the DT cord-010092-uftc8inx 1717 25 difference difference NN cord-010092-uftc8inx 1717 26 between between IN cord-010092-uftc8inx 1717 27 finger finger NN cord-010092-uftc8inx 1717 28 prick prick NN cord-010092-uftc8inx 1717 29 and and CC cord-010092-uftc8inx 1717 30 venous venous JJ cord-010092-uftc8inx 1717 31 Hb Hb NNP cord-010092-uftc8inx 1717 32 measurements measurement NNS cord-010092-uftc8inx 1717 33 in in IN cord-010092-uftc8inx 1717 34 this this DT cord-010092-uftc8inx 1717 35 study study NN cord-010092-uftc8inx 1717 36 . . . cord-010092-uftc8inx 1718 1 Summary Summary NNP cord-010092-uftc8inx 1718 2 / / SYM cord-010092-uftc8inx 1718 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 1718 4 : : : cord-010092-uftc8inx 1719 1 The the DT cord-010092-uftc8inx 1719 2 results result NNS cord-010092-uftc8inx 1719 3 of of IN cord-010092-uftc8inx 1719 4 the the DT cord-010092-uftc8inx 1719 5 POC POC NNP cord-010092-uftc8inx 1719 6 measurements measurement NNS cord-010092-uftc8inx 1719 7 compared compare VBN cord-010092-uftc8inx 1719 8 to to IN cord-010092-uftc8inx 1719 9 the the DT cord-010092-uftc8inx 1719 10 cell cell NN cord-010092-uftc8inx 1719 11 counter counter NN cord-010092-uftc8inx 1719 12 were be VBD cord-010092-uftc8inx 1719 13 in in IN cord-010092-uftc8inx 1719 14 agreement agreement NN cord-010092-uftc8inx 1719 15 with with IN cord-010092-uftc8inx 1719 16 published publish VBN cord-010092-uftc8inx 1719 17 data datum NNS cord-010092-uftc8inx 1719 18 and and CC cord-010092-uftc8inx 1719 19 with with IN cord-010092-uftc8inx 1719 20 manufacturers manufacturer NNS cord-010092-uftc8inx 1719 21 ' ' POS cord-010092-uftc8inx 1719 22 information information NN cord-010092-uftc8inx 1719 23 on on IN cord-010092-uftc8inx 1719 24 the the DT cord-010092-uftc8inx 1719 25 device device NN cord-010092-uftc8inx 1719 26 . . . cord-010092-uftc8inx 1720 1 The the DT cord-010092-uftc8inx 1720 2 practical practical JJ cord-010092-uftc8inx 1720 3 skill skill NN cord-010092-uftc8inx 1720 4 test test NN cord-010092-uftc8inx 1720 5 is be VBZ cord-010092-uftc8inx 1720 6 a a DT cord-010092-uftc8inx 1720 7 workable workable JJ cord-010092-uftc8inx 1720 8 way way NN cord-010092-uftc8inx 1720 9 to to TO cord-010092-uftc8inx 1720 10 develop develop VB cord-010092-uftc8inx 1720 11 competence competence NN cord-010092-uftc8inx 1720 12 and and CC cord-010092-uftc8inx 1720 13 operations operation NNS cord-010092-uftc8inx 1720 14 to to TO cord-010092-uftc8inx 1720 15 measure measure VB cord-010092-uftc8inx 1720 16 the the DT cord-010092-uftc8inx 1720 17 hemoglobin hemoglobin NN cord-010092-uftc8inx 1720 18 from from IN cord-010092-uftc8inx 1720 19 the the DT cord-010092-uftc8inx 1720 20 finger finger NN cord-010092-uftc8inx 1720 21 prick prick NN cord-010092-uftc8inx 1720 22 . . . cord-010092-uftc8inx 1721 1 It -PRON- PRP cord-010092-uftc8inx 1721 2 offers offer VBZ cord-010092-uftc8inx 1721 3 an an DT cord-010092-uftc8inx 1721 4 opportunity opportunity NN cord-010092-uftc8inx 1721 5 to to TO cord-010092-uftc8inx 1721 6 give give VB cord-010092-uftc8inx 1721 7 personal personal JJ cord-010092-uftc8inx 1721 8 feedback feedback NN cord-010092-uftc8inx 1721 9 to to IN cord-010092-uftc8inx 1721 10 nurses nurse NNS cord-010092-uftc8inx 1721 11 concerning concern VBG cord-010092-uftc8inx 1721 12 their -PRON- PRP$ cord-010092-uftc8inx 1721 13 personal personal JJ cord-010092-uftc8inx 1721 14 performance performance NN cord-010092-uftc8inx 1721 15 in in IN cord-010092-uftc8inx 1721 16 the the DT cord-010092-uftc8inx 1721 17 use use NN cord-010092-uftc8inx 1721 18 of of IN cord-010092-uftc8inx 1721 19 the the DT cord-010092-uftc8inx 1721 20 current current JJ cord-010092-uftc8inx 1721 21 Hb Hb NNP cord-010092-uftc8inx 1721 22 measurement measurement NN cord-010092-uftc8inx 1721 23 technic technic NN cord-010092-uftc8inx 1721 24 . . . cord-010092-uftc8inx 1722 1 It -PRON- PRP cord-010092-uftc8inx 1722 2 also also RB cord-010092-uftc8inx 1722 3 provided provide VBD cord-010092-uftc8inx 1722 4 data datum NNS cord-010092-uftc8inx 1722 5 on on IN cord-010092-uftc8inx 1722 6 the the DT cord-010092-uftc8inx 1722 7 accuracy accuracy NN cord-010092-uftc8inx 1722 8 of of IN cord-010092-uftc8inx 1722 9 the the DT cord-010092-uftc8inx 1722 10 POC POC NNP cord-010092-uftc8inx 1722 11 method method NN cord-010092-uftc8inx 1722 12 in in IN cord-010092-uftc8inx 1722 13 the the DT cord-010092-uftc8inx 1722 14 everyday everyday JJ cord-010092-uftc8inx 1722 15 donor donor NN cord-010092-uftc8inx 1722 16 selection selection NN cord-010092-uftc8inx 1722 17 process process NN cord-010092-uftc8inx 1722 18 . . . cord-010092-uftc8inx 1723 1 Background background NN cord-010092-uftc8inx 1723 2 : : : cord-010092-uftc8inx 1724 1 Whole whole JJ cord-010092-uftc8inx 1724 2 blood blood NN cord-010092-uftc8inx 1724 3 donation donation NN cord-010092-uftc8inx 1724 4 has have VBZ cord-010092-uftc8inx 1724 5 frequently frequently RB cord-010092-uftc8inx 1724 6 been be VBN cord-010092-uftc8inx 1724 7 related relate VBN cord-010092-uftc8inx 1724 8 to to IN cord-010092-uftc8inx 1724 9 iron iron NN cord-010092-uftc8inx 1724 10 deficiency deficiency NN cord-010092-uftc8inx 1724 11 . . . cord-010092-uftc8inx 1725 1 A a DT cord-010092-uftc8inx 1725 2 blood blood NN cord-010092-uftc8inx 1725 3 donor donor NN cord-010092-uftc8inx 1725 4 loses lose VBZ cord-010092-uftc8inx 1725 5 per per IN cord-010092-uftc8inx 1725 6 donation donation NN cord-010092-uftc8inx 1725 7 about about IN cord-010092-uftc8inx 1725 8 8 8 CD cord-010092-uftc8inx 1725 9 % % NN cord-010092-uftc8inx 1725 10 ( ( -LRB- cord-010092-uftc8inx 1725 11 men man NNS cord-010092-uftc8inx 1725 12 ) ) -RRB- cord-010092-uftc8inx 1725 13 to to IN cord-010092-uftc8inx 1725 14 81 81 CD cord-010092-uftc8inx 1725 15 % % NN cord-010092-uftc8inx 1725 16 ( ( -LRB- cord-010092-uftc8inx 1725 17 menstruating menstruate VBG cord-010092-uftc8inx 1725 18 women woman NNS cord-010092-uftc8inx 1725 19 ) ) -RRB- cord-010092-uftc8inx 1725 20 of of IN cord-010092-uftc8inx 1725 21 iron iron NN cord-010092-uftc8inx 1725 22 stores store NNS cord-010092-uftc8inx 1725 23 . . . cord-010092-uftc8inx 1726 1 To to TO cord-010092-uftc8inx 1726 2 replenish replenish VB cord-010092-uftc8inx 1726 3 the the DT cord-010092-uftc8inx 1726 4 iron iron NN cord-010092-uftc8inx 1726 5 lost lose VBN cord-010092-uftc8inx 1726 6 by by IN cord-010092-uftc8inx 1726 7 blood blood NN cord-010092-uftc8inx 1726 8 donation donation NN cord-010092-uftc8inx 1726 9 in in IN cord-010092-uftc8inx 1726 10 a a DT cord-010092-uftc8inx 1726 11 donation donation NN cord-010092-uftc8inx 1726 12 interval interval NN cord-010092-uftc8inx 1726 13 of of IN cord-010092-uftc8inx 1726 14 56 56 CD cord-010092-uftc8inx 1726 15 days day NNS cord-010092-uftc8inx 1726 16 , , , cord-010092-uftc8inx 1726 17 a a DT cord-010092-uftc8inx 1726 18 donor donor NN cord-010092-uftc8inx 1726 19 needs need VBZ cord-010092-uftc8inx 1726 20 to to TO cord-010092-uftc8inx 1726 21 absorb absorb VB cord-010092-uftc8inx 1726 22 4.5 4.5 CD cord-010092-uftc8inx 1726 23 mg mg NN cord-010092-uftc8inx 1726 24 iron iron NN cord-010092-uftc8inx 1726 25 per per IN cord-010092-uftc8inx 1726 26 day day NN cord-010092-uftc8inx 1726 27 . . . cord-010092-uftc8inx 1727 1 This this DT cord-010092-uftc8inx 1727 2 amount amount NN cord-010092-uftc8inx 1727 3 exceeds exceed VBZ cord-010092-uftc8inx 1727 4 the the DT cord-010092-uftc8inx 1727 5 reported report VBN cord-010092-uftc8inx 1727 6 maximal maximal JJ cord-010092-uftc8inx 1727 7 amount amount NN cord-010092-uftc8inx 1727 8 of of IN cord-010092-uftc8inx 1727 9 absorbed absorb VBN cord-010092-uftc8inx 1727 10 iron iron NN cord-010092-uftc8inx 1727 11 of of IN cord-010092-uftc8inx 1727 12 3 3 CD cord-010092-uftc8inx 1727 13 - - SYM cord-010092-uftc8inx 1727 14 4 4 CD cord-010092-uftc8inx 1727 15 mg mg NNP cord-010092-uftc8inx 1727 16 / / SYM cord-010092-uftc8inx 1727 17 day day NN cord-010092-uftc8inx 1727 18 , , , cord-010092-uftc8inx 1727 19 eventually eventually RB cord-010092-uftc8inx 1727 20 leading lead VBG cord-010092-uftc8inx 1727 21 to to IN cord-010092-uftc8inx 1727 22 iron iron NN cord-010092-uftc8inx 1727 23 deficiency deficiency NN cord-010092-uftc8inx 1727 24 , , , cord-010092-uftc8inx 1727 25 with with IN cord-010092-uftc8inx 1727 26 consequences consequence NNS cord-010092-uftc8inx 1727 27 such such JJ cord-010092-uftc8inx 1727 28 as as IN cord-010092-uftc8inx 1727 29 donor donor NN cord-010092-uftc8inx 1727 30 deferral deferral NN cord-010092-uftc8inx 1727 31 and and CC cord-010092-uftc8inx 1727 32 possibly possibly RB cord-010092-uftc8inx 1727 33 iron iron NN cord-010092-uftc8inx 1727 34 deficiency deficiency NN cord-010092-uftc8inx 1727 35 - - HYPH cord-010092-uftc8inx 1727 36 related relate VBN cord-010092-uftc8inx 1727 37 symptoms symptom NNS cord-010092-uftc8inx 1727 38 ( ( -LRB- cord-010092-uftc8inx 1727 39 decreased decrease VBD cord-010092-uftc8inx 1727 40 physical physical JJ cord-010092-uftc8inx 1727 41 endurance endurance NN cord-010092-uftc8inx 1727 42 , , , cord-010092-uftc8inx 1727 43 fatigue fatigue NN cord-010092-uftc8inx 1727 44 , , , cord-010092-uftc8inx 1727 45 pica pica NN cord-010092-uftc8inx 1727 46 , , , cord-010092-uftc8inx 1727 47 restless restless JJ cord-010092-uftc8inx 1727 48 legs leg NNS cord-010092-uftc8inx 1727 49 syndrome syndrome NN cord-010092-uftc8inx 1727 50 , , , cord-010092-uftc8inx 1727 51 and and CC cord-010092-uftc8inx 1727 52 cognitive cognitive JJ cord-010092-uftc8inx 1727 53 functions function NNS cord-010092-uftc8inx 1727 54 ) ) -RRB- cord-010092-uftc8inx 1727 55 . . . cord-010092-uftc8inx 1728 1 Since since IN cord-010092-uftc8inx 1728 2 Hb Hb NNP cord-010092-uftc8inx 1728 3 levels level NNS cord-010092-uftc8inx 1728 4 do do VBP cord-010092-uftc8inx 1728 5 not not RB cord-010092-uftc8inx 1728 6 reflect reflect VB cord-010092-uftc8inx 1728 7 donors donor NNS cord-010092-uftc8inx 1728 8 ' ' POS cord-010092-uftc8inx 1728 9 true true JJ cord-010092-uftc8inx 1728 10 iron iron NN cord-010092-uftc8inx 1728 11 status status NN cord-010092-uftc8inx 1728 12 , , , cord-010092-uftc8inx 1728 13 measuring measure VBG cord-010092-uftc8inx 1728 14 ferritin ferritin NN cord-010092-uftc8inx 1728 15 is be VBZ cord-010092-uftc8inx 1728 16 a a DT cord-010092-uftc8inx 1728 17 better well JJR cord-010092-uftc8inx 1728 18 way way NN cord-010092-uftc8inx 1728 19 to to TO cord-010092-uftc8inx 1728 20 detect detect VB cord-010092-uftc8inx 1728 21 low low JJ cord-010092-uftc8inx 1728 22 iron iron NN cord-010092-uftc8inx 1728 23 stores store NNS cord-010092-uftc8inx 1728 24 in in IN cord-010092-uftc8inx 1728 25 whole whole JJ cord-010092-uftc8inx 1728 26 blood blood NN cord-010092-uftc8inx 1728 27 donors donor NNS cord-010092-uftc8inx 1728 28 . . . cord-010092-uftc8inx 1729 1 Studies study NNS cord-010092-uftc8inx 1729 2 from from IN cord-010092-uftc8inx 1729 3 USA USA NNP cord-010092-uftc8inx 1729 4 and and CC cord-010092-uftc8inx 1729 5 Denmark Denmark NNP cord-010092-uftc8inx 1729 6 showed show VBD cord-010092-uftc8inx 1729 7 that that IN cord-010092-uftc8inx 1729 8 on on IN cord-010092-uftc8inx 1729 9 the the DT cord-010092-uftc8inx 1729 10 introduction introduction NN cord-010092-uftc8inx 1729 11 of of IN cord-010092-uftc8inx 1729 12 ferritin ferritin NN cord-010092-uftc8inx 1729 13 measurement measurement NN cord-010092-uftc8inx 1729 14 with with IN cord-010092-uftc8inx 1729 15 either either DT cord-010092-uftc8inx 1729 16 extension extension NN cord-010092-uftc8inx 1729 17 of of IN cord-010092-uftc8inx 1729 18 donation donation NN cord-010092-uftc8inx 1729 19 intervals interval NNS cord-010092-uftc8inx 1729 20 or or CC cord-010092-uftc8inx 1729 21 iron iron NN cord-010092-uftc8inx 1729 22 supplementation supplementation NN cord-010092-uftc8inx 1729 23 in in IN cord-010092-uftc8inx 1729 24 case case NN cord-010092-uftc8inx 1729 25 of of IN cord-010092-uftc8inx 1729 26 low low JJ cord-010092-uftc8inx 1729 27 iron iron NN cord-010092-uftc8inx 1729 28 stores store NNS cord-010092-uftc8inx 1729 29 , , , cord-010092-uftc8inx 1729 30 deferral deferral NN cord-010092-uftc8inx 1729 31 percentages percentage NNS cord-010092-uftc8inx 1729 32 for for IN cord-010092-uftc8inx 1729 33 low low JJ cord-010092-uftc8inx 1729 34 Hb Hb NNP cord-010092-uftc8inx 1729 35 declined decline VBD cord-010092-uftc8inx 1729 36 in in IN cord-010092-uftc8inx 1729 37 both both DT cord-010092-uftc8inx 1729 38 male male JJ cord-010092-uftc8inx 1729 39 and and CC cord-010092-uftc8inx 1729 40 female female JJ cord-010092-uftc8inx 1729 41 donors donor NNS cord-010092-uftc8inx 1729 42 . . . cord-010092-uftc8inx 1730 1 Aims aim VBZ cord-010092-uftc8inx 1730 2 : : : cord-010092-uftc8inx 1731 1 To to TO cord-010092-uftc8inx 1731 2 gain gain VB cord-010092-uftc8inx 1731 3 more more JJR cord-010092-uftc8inx 1731 4 insight insight NN cord-010092-uftc8inx 1731 5 in in IN cord-010092-uftc8inx 1731 6 iron iron NN cord-010092-uftc8inx 1731 7 status status NN cord-010092-uftc8inx 1731 8 of of IN cord-010092-uftc8inx 1731 9 whole whole JJ cord-010092-uftc8inx 1731 10 blood blood NN cord-010092-uftc8inx 1731 11 donors donor NNS cord-010092-uftc8inx 1731 12 during during IN cord-010092-uftc8inx 1731 13 their -PRON- PRP$ cord-010092-uftc8inx 1731 14 donor donor NN cord-010092-uftc8inx 1731 15 career career NN cord-010092-uftc8inx 1731 16 , , , cord-010092-uftc8inx 1731 17 how how WRB cord-010092-uftc8inx 1731 18 this this DT cord-010092-uftc8inx 1731 19 affects affect VBZ cord-010092-uftc8inx 1731 20 donor donor NN cord-010092-uftc8inx 1731 21 health health NN cord-010092-uftc8inx 1731 22 and and CC cord-010092-uftc8inx 1731 23 which which WDT cord-010092-uftc8inx 1731 24 measures measure NNS cord-010092-uftc8inx 1731 25 may may MD cord-010092-uftc8inx 1731 26 prevent prevent VB cord-010092-uftc8inx 1731 27 low low JJ cord-010092-uftc8inx 1731 28 iron iron NN cord-010092-uftc8inx 1731 29 stores store NNS cord-010092-uftc8inx 1731 30 in in IN cord-010092-uftc8inx 1731 31 donors donor NNS cord-010092-uftc8inx 1731 32 . . . cord-010092-uftc8inx 1732 1 Methods method NNS cord-010092-uftc8inx 1732 2 : : : cord-010092-uftc8inx 1732 3 In in IN cord-010092-uftc8inx 1732 4 the the DT cord-010092-uftc8inx 1732 5 Netherlands Netherlands NNP cord-010092-uftc8inx 1732 6 , , , cord-010092-uftc8inx 1732 7 Sanquin Sanquin NNP cord-010092-uftc8inx 1732 8 Blood Blood NNP cord-010092-uftc8inx 1732 9 Bank Bank NNP cord-010092-uftc8inx 1732 10 is be VBZ cord-010092-uftc8inx 1732 11 currently currently RB cord-010092-uftc8inx 1732 12 implementing implement VBG cord-010092-uftc8inx 1732 13 a a DT cord-010092-uftc8inx 1732 14 policy policy NN cord-010092-uftc8inx 1732 15 with with IN cord-010092-uftc8inx 1732 16 ferritin ferritin NN cord-010092-uftc8inx 1732 17 - - HYPH cord-010092-uftc8inx 1732 18 guided guide VBN cord-010092-uftc8inx 1732 19 donation donation NN cord-010092-uftc8inx 1732 20 intervals interval NNS cord-010092-uftc8inx 1732 21 . . . cord-010092-uftc8inx 1733 1 In in IN cord-010092-uftc8inx 1733 2 brief brief NN cord-010092-uftc8inx 1733 3 , , , cord-010092-uftc8inx 1733 4 ferritin ferritin NN cord-010092-uftc8inx 1733 5 levels level NNS cord-010092-uftc8inx 1733 6 are be VBP cord-010092-uftc8inx 1733 7 measured measure VBN cord-010092-uftc8inx 1733 8 in in IN cord-010092-uftc8inx 1733 9 all all DT cord-010092-uftc8inx 1733 10 new new JJ cord-010092-uftc8inx 1733 11 donors donor NNS cord-010092-uftc8inx 1733 12 and and CC cord-010092-uftc8inx 1733 13 in in IN cord-010092-uftc8inx 1733 14 repeat repeat NN cord-010092-uftc8inx 1733 15 donors donor NNS cord-010092-uftc8inx 1733 16 every every DT cord-010092-uftc8inx 1733 17 5th 5th JJ cord-010092-uftc8inx 1733 18 donation donation NN cord-010092-uftc8inx 1733 19 or or CC cord-010092-uftc8inx 1733 20 in in IN cord-010092-uftc8inx 1733 21 case case NN cord-010092-uftc8inx 1733 22 of of IN cord-010092-uftc8inx 1733 23 an an DT cord-010092-uftc8inx 1733 24 Hb Hb NNP cord-010092-uftc8inx 1733 25 below below IN cord-010092-uftc8inx 1733 26 the the DT cord-010092-uftc8inx 1733 27 deferral deferral NN cord-010092-uftc8inx 1733 28 threshold threshold NN cord-010092-uftc8inx 1733 29 . . . cord-010092-uftc8inx 1734 1 Donation donation NN cord-010092-uftc8inx 1734 2 intervals interval NNS cord-010092-uftc8inx 1734 3 are be VBP cord-010092-uftc8inx 1734 4 extended extend VBN cord-010092-uftc8inx 1734 5 if if IN cord-010092-uftc8inx 1734 6 ferritin ferritin NN cord-010092-uftc8inx 1734 7 levels level NNS cord-010092-uftc8inx 1734 8 are be VBP cord-010092-uftc8inx 1734 9 < < XX cord-010092-uftc8inx 1734 10 15 15 CD cord-010092-uftc8inx 1734 11 lg/ lg/ CD cord-010092-uftc8inx 1734 12 L L NNP cord-010092-uftc8inx 1734 13 , , , cord-010092-uftc8inx 1734 14 or or CC cord-010092-uftc8inx 1734 15 ≥ ≥ CD cord-010092-uftc8inx 1734 16 15 15 CD cord-010092-uftc8inx 1734 17 and and CC cord-010092-uftc8inx 1734 18 ≤ ≤ NNP cord-010092-uftc8inx 1734 19 30 30 CD cord-010092-uftc8inx 1734 20 lg lg NNP cord-010092-uftc8inx 1734 21 / / SYM cord-010092-uftc8inx 1734 22 L L NNP cord-010092-uftc8inx 1734 23 ( ( -LRB- cord-010092-uftc8inx 1734 24 for for IN cord-010092-uftc8inx 1734 25 12 12 CD cord-010092-uftc8inx 1734 26 and and CC cord-010092-uftc8inx 1734 27 6 6 CD cord-010092-uftc8inx 1734 28 months month NNS cord-010092-uftc8inx 1734 29 respectively respectively RB cord-010092-uftc8inx 1734 30 ) ) -RRB- cord-010092-uftc8inx 1734 31 . . . cord-010092-uftc8inx 1735 1 We -PRON- PRP cord-010092-uftc8inx 1735 2 anticipate anticipate VBP cord-010092-uftc8inx 1735 3 that that IN cord-010092-uftc8inx 1735 4 routine routine JJ cord-010092-uftc8inx 1735 5 ferritin ferritin NN cord-010092-uftc8inx 1735 6 measurement measurement NN cord-010092-uftc8inx 1735 7 will will MD cord-010092-uftc8inx 1735 8 ultimately ultimately RB cord-010092-uftc8inx 1735 9 result result VB cord-010092-uftc8inx 1735 10 in in IN cord-010092-uftc8inx 1735 11 a a DT cord-010092-uftc8inx 1735 12 lower low JJR cord-010092-uftc8inx 1735 13 prevalence prevalence NN cord-010092-uftc8inx 1735 14 of of IN cord-010092-uftc8inx 1735 15 iron iron NN cord-010092-uftc8inx 1735 16 deficiency deficiency NN cord-010092-uftc8inx 1735 17 , , , cord-010092-uftc8inx 1735 18 less less JJR cord-010092-uftc8inx 1735 19 Hb Hb NNP cord-010092-uftc8inx 1735 20 deferrals deferral NNS cord-010092-uftc8inx 1735 21 and and CC cord-010092-uftc8inx 1735 22 improved improved JJ cord-010092-uftc8inx 1735 23 donor donor NN cord-010092-uftc8inx 1735 24 retention retention NN cord-010092-uftc8inx 1735 25 . . . cord-010092-uftc8inx 1736 1 This this DT cord-010092-uftc8inx 1736 2 will will MD cord-010092-uftc8inx 1736 3 be be VB cord-010092-uftc8inx 1736 4 further further RB cord-010092-uftc8inx 1736 5 evaluated evaluate VBN cord-010092-uftc8inx 1736 6 in in IN cord-010092-uftc8inx 1736 7 a a DT cord-010092-uftc8inx 1736 8 stepped step VBN cord-010092-uftc8inx 1736 9 wedge wedge NN cord-010092-uftc8inx 1736 10 cluster cluster NN cord-010092-uftc8inx 1736 11 - - HYPH cord-010092-uftc8inx 1736 12 randomized randomized JJ cord-010092-uftc8inx 1736 13 trial trial NN cord-010092-uftc8inx 1736 14 ' ' `` cord-010092-uftc8inx 1736 15 FIND'EM FIND'EM NNP cord-010092-uftc8inx 1736 16 ' ' '' cord-010092-uftc8inx 1736 17 , , , cord-010092-uftc8inx 1736 18 which which WDT cord-010092-uftc8inx 1736 19 may may MD cord-010092-uftc8inx 1736 20 also also RB cord-010092-uftc8inx 1736 21 identify identify VB cord-010092-uftc8inx 1736 22 subgroups subgroup NNS cord-010092-uftc8inx 1736 23 of of IN cord-010092-uftc8inx 1736 24 donors donor NNS cord-010092-uftc8inx 1736 25 prone prone JJ cord-010092-uftc8inx 1736 26 to to TO cord-010092-uftc8inx 1736 27 develop develop VB cord-010092-uftc8inx 1736 28 ( ( -LRB- cord-010092-uftc8inx 1736 29 symptoms symptom NNS cord-010092-uftc8inx 1736 30 of of IN cord-010092-uftc8inx 1736 31 ) ) -RRB- cord-010092-uftc8inx 1736 32 iron iron NN cord-010092-uftc8inx 1736 33 deficiency deficiency NN cord-010092-uftc8inx 1736 34 . . . cord-010092-uftc8inx 1737 1 In in IN cord-010092-uftc8inx 1737 2 addition addition NN cord-010092-uftc8inx 1737 3 , , , cord-010092-uftc8inx 1737 4 implementing implement VBG cord-010092-uftc8inx 1737 5 ferritin ferritin NN cord-010092-uftc8inx 1737 6 screening screening NN cord-010092-uftc8inx 1737 7 may may MD cord-010092-uftc8inx 1737 8 lead lead VB cord-010092-uftc8inx 1737 9 to to IN cord-010092-uftc8inx 1737 10 a a DT cord-010092-uftc8inx 1737 11 decreased decrease VBN cord-010092-uftc8inx 1737 12 donor donor NN cord-010092-uftc8inx 1737 13 availability availability NN cord-010092-uftc8inx 1737 14 . . . cord-010092-uftc8inx 1738 1 For for IN cord-010092-uftc8inx 1738 2 this this DT cord-010092-uftc8inx 1738 3 purpose purpose NN cord-010092-uftc8inx 1738 4 , , , cord-010092-uftc8inx 1738 5 we -PRON- PRP cord-010092-uftc8inx 1738 6 modeled model VBD cord-010092-uftc8inx 1738 7 the the DT cord-010092-uftc8inx 1738 8 impact impact NN cord-010092-uftc8inx 1738 9 of of IN cord-010092-uftc8inx 1738 10 the the DT cord-010092-uftc8inx 1738 11 implementation implementation NN cord-010092-uftc8inx 1738 12 of of IN cord-010092-uftc8inx 1738 13 our -PRON- PRP$ cord-010092-uftc8inx 1738 14 ferritin ferritin NN cord-010092-uftc8inx 1738 15 deferral deferral NN cord-010092-uftc8inx 1738 16 policy policy NN cord-010092-uftc8inx 1738 17 on on IN cord-010092-uftc8inx 1738 18 donor donor NN cord-010092-uftc8inx 1738 19 availability availability NN cord-010092-uftc8inx 1738 20 over over IN cord-010092-uftc8inx 1738 21 time time NN cord-010092-uftc8inx 1738 22 , , , cord-010092-uftc8inx 1738 23 which which WDT cord-010092-uftc8inx 1738 24 provides provide VBZ cord-010092-uftc8inx 1738 25 insight insight NN cord-010092-uftc8inx 1738 26 for for IN cord-010092-uftc8inx 1738 27 both both CC cord-010092-uftc8inx 1738 28 the the DT cord-010092-uftc8inx 1738 29 expected expect VBN cord-010092-uftc8inx 1738 30 size size NN cord-010092-uftc8inx 1738 31 of of IN cord-010092-uftc8inx 1738 32 the the DT cord-010092-uftc8inx 1738 33 impact impact NN cord-010092-uftc8inx 1738 34 of of IN cord-010092-uftc8inx 1738 35 the the DT cord-010092-uftc8inx 1738 36 ferritin ferritin NN cord-010092-uftc8inx 1738 37 deferral deferral NN cord-010092-uftc8inx 1738 38 policy policy NN cord-010092-uftc8inx 1738 39 and and CC cord-010092-uftc8inx 1738 40 the the DT cord-010092-uftc8inx 1738 41 time time NN cord-010092-uftc8inx 1738 42 and and CC cord-010092-uftc8inx 1738 43 rate rate NN cord-010092-uftc8inx 1738 44 at at IN cord-010092-uftc8inx 1738 45 which which WDT cord-010092-uftc8inx 1738 46 this this DT cord-010092-uftc8inx 1738 47 impact impact NN cord-010092-uftc8inx 1738 48 is be VBZ cord-010092-uftc8inx 1738 49 expected expect VBN cord-010092-uftc8inx 1738 50 to to TO cord-010092-uftc8inx 1738 51 occur occur VB cord-010092-uftc8inx 1738 52 . . . cord-010092-uftc8inx 1739 1 This this DT cord-010092-uftc8inx 1739 2 allows allow VBZ cord-010092-uftc8inx 1739 3 the the DT cord-010092-uftc8inx 1739 4 blood blood NN cord-010092-uftc8inx 1739 5 bank bank NN cord-010092-uftc8inx 1739 6 to to TO cord-010092-uftc8inx 1739 7 timely timely JJ cord-010092-uftc8inx 1739 8 plan plan NN cord-010092-uftc8inx 1739 9 actions action NNS cord-010092-uftc8inx 1739 10 to to TO cord-010092-uftc8inx 1739 11 counterbalance counterbalance VB cord-010092-uftc8inx 1739 12 possible possible JJ cord-010092-uftc8inx 1739 13 donor donor NN cord-010092-uftc8inx 1739 14 shortage shortage NN cord-010092-uftc8inx 1739 15 and and CC cord-010092-uftc8inx 1739 16 ensure ensure VB cord-010092-uftc8inx 1739 17 an an DT cord-010092-uftc8inx 1739 18 adequate adequate JJ cord-010092-uftc8inx 1739 19 blood blood NN cord-010092-uftc8inx 1739 20 supply supply NN cord-010092-uftc8inx 1739 21 . . . cord-010092-uftc8inx 1740 1 Lastly lastly RB cord-010092-uftc8inx 1740 2 , , , cord-010092-uftc8inx 1740 3 iron iron NN cord-010092-uftc8inx 1740 4 supplementation supplementation NN cord-010092-uftc8inx 1740 5 can can MD cord-010092-uftc8inx 1740 6 be be VB cord-010092-uftc8inx 1740 7 an an DT cord-010092-uftc8inx 1740 8 alternative alternative JJ cord-010092-uftc8inx 1740 9 measure measure NN cord-010092-uftc8inx 1740 10 instead instead RB cord-010092-uftc8inx 1740 11 of of IN cord-010092-uftc8inx 1740 12 donation donation NN cord-010092-uftc8inx 1740 13 deferral deferral NN cord-010092-uftc8inx 1740 14 . . . cord-010092-uftc8inx 1741 1 As as IN cord-010092-uftc8inx 1741 2 the the DT cord-010092-uftc8inx 1741 3 used use VBN cord-010092-uftc8inx 1741 4 and and CC cord-010092-uftc8inx 1741 5 recommended recommend VBN cord-010092-uftc8inx 1741 6 dosage dosage NN cord-010092-uftc8inx 1741 7 of of IN cord-010092-uftc8inx 1741 8 iron iron NN cord-010092-uftc8inx 1741 9 supplementation supplementation NN cord-010092-uftc8inx 1741 10 varies vary VBZ cord-010092-uftc8inx 1741 11 widely widely RB cord-010092-uftc8inx 1741 12 across across IN cord-010092-uftc8inx 1741 13 blood blood NN cord-010092-uftc8inx 1741 14 services service NNS cord-010092-uftc8inx 1741 15 , , , cord-010092-uftc8inx 1741 16 Sanquin Sanquin NNP cord-010092-uftc8inx 1741 17 is be VBZ cord-010092-uftc8inx 1741 18 planning plan VBG cord-010092-uftc8inx 1741 19 to to TO cord-010092-uftc8inx 1741 20 start start VB cord-010092-uftc8inx 1741 21 a a DT cord-010092-uftc8inx 1741 22 new new JJ cord-010092-uftc8inx 1741 23 study study NN cord-010092-uftc8inx 1741 24 in in IN cord-010092-uftc8inx 1741 25 whole whole JJ cord-010092-uftc8inx 1741 26 blood blood NN cord-010092-uftc8inx 1741 27 donors donor NNS cord-010092-uftc8inx 1741 28 to to TO cord-010092-uftc8inx 1741 29 gain gain VB cord-010092-uftc8inx 1741 30 evidence evidence NN cord-010092-uftc8inx 1741 31 on on IN cord-010092-uftc8inx 1741 32 the the DT cord-010092-uftc8inx 1741 33 dosage dosage NN cord-010092-uftc8inx 1741 34 and and CC cord-010092-uftc8inx 1741 35 frequency frequency NN cord-010092-uftc8inx 1741 36 of of IN cord-010092-uftc8inx 1741 37 iron iron NN cord-010092-uftc8inx 1741 38 supplementation supplementation NN cord-010092-uftc8inx 1741 39 and and CC cord-010092-uftc8inx 1741 40 its -PRON- PRP$ cord-010092-uftc8inx 1741 41 effect effect NN cord-010092-uftc8inx 1741 42 on on IN cord-010092-uftc8inx 1741 43 ferritin ferritin NN cord-010092-uftc8inx 1741 44 and and CC cord-010092-uftc8inx 1741 45 hemoglobin hemoglobin NN cord-010092-uftc8inx 1741 46 levels level NNS cord-010092-uftc8inx 1741 47 and and CC cord-010092-uftc8inx 1741 48 donor donor NN cord-010092-uftc8inx 1741 49 health health NN cord-010092-uftc8inx 1741 50 . . . cord-010092-uftc8inx 1742 1 Results result NNS cord-010092-uftc8inx 1742 2 : : : cord-010092-uftc8inx 1743 1 The the DT cord-010092-uftc8inx 1743 2 before before RB cord-010092-uftc8inx 1743 3 - - HYPH cord-010092-uftc8inx 1743 4 mentioned mention VBN cord-010092-uftc8inx 1743 5 studies study NNS cord-010092-uftc8inx 1743 6 are be VBP cord-010092-uftc8inx 1743 7 ongoing ongoing JJ cord-010092-uftc8inx 1743 8 and and CC cord-010092-uftc8inx 1743 9 results result NNS cord-010092-uftc8inx 1743 10 will will MD cord-010092-uftc8inx 1743 11 be be VB cord-010092-uftc8inx 1743 12 expected expect VBN cord-010092-uftc8inx 1743 13 from from IN cord-010092-uftc8inx 1743 14 2020 2020 CD cord-010092-uftc8inx 1743 15 onwards onwards RB cord-010092-uftc8inx 1743 16 . . . cord-010092-uftc8inx 1744 1 Summary Summary NNP cord-010092-uftc8inx 1744 2 / / SYM cord-010092-uftc8inx 1744 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 1744 4 : : : cord-010092-uftc8inx 1745 1 Iron iron NN cord-010092-uftc8inx 1745 2 deficiency deficiency NN cord-010092-uftc8inx 1745 3 is be VBZ cord-010092-uftc8inx 1745 4 a a DT cord-010092-uftc8inx 1745 5 frequent frequent JJ cord-010092-uftc8inx 1745 6 side side NN cord-010092-uftc8inx 1745 7 effect effect NN cord-010092-uftc8inx 1745 8 of of IN cord-010092-uftc8inx 1745 9 whole whole JJ cord-010092-uftc8inx 1745 10 blood blood NN cord-010092-uftc8inx 1745 11 donation donation NN cord-010092-uftc8inx 1745 12 . . . cord-010092-uftc8inx 1746 1 To to TO cord-010092-uftc8inx 1746 2 prevent prevent VB cord-010092-uftc8inx 1746 3 iron iron NN cord-010092-uftc8inx 1746 4 deficiency deficiency NN cord-010092-uftc8inx 1746 5 and and CC cord-010092-uftc8inx 1746 6 its -PRON- PRP$ cord-010092-uftc8inx 1746 7 consequences consequence NNS cord-010092-uftc8inx 1746 8 , , , cord-010092-uftc8inx 1746 9 like like IN cord-010092-uftc8inx 1746 10 donation donation NN cord-010092-uftc8inx 1746 11 deferral deferral NN cord-010092-uftc8inx 1746 12 and and CC cord-010092-uftc8inx 1746 13 health health NN cord-010092-uftc8inx 1746 14 issues issue NNS cord-010092-uftc8inx 1746 15 , , , cord-010092-uftc8inx 1746 16 more more JJR cord-010092-uftc8inx 1746 17 evidence evidence NN cord-010092-uftc8inx 1746 18 - - HYPH cord-010092-uftc8inx 1746 19 based base VBN cord-010092-uftc8inx 1746 20 insight insight NN cord-010092-uftc8inx 1746 21 in in IN cord-010092-uftc8inx 1746 22 iron iron NN cord-010092-uftc8inx 1746 23 management management NN cord-010092-uftc8inx 1746 24 of of IN cord-010092-uftc8inx 1746 25 whole whole JJ cord-010092-uftc8inx 1746 26 blood blood NN cord-010092-uftc8inx 1746 27 donors donor NNS cord-010092-uftc8inx 1746 28 is be VBZ cord-010092-uftc8inx 1746 29 being be VBG cord-010092-uftc8inx 1746 30 generated generate VBN cord-010092-uftc8inx 1746 31 . . . cord-010092-uftc8inx 1747 1 3D 3d JJ cord-010092-uftc8inx 1747 2 - - HYPH cord-010092-uftc8inx 1747 3 S15 S15 NNP cord-010092-uftc8inx 1747 4 - - HYPH cord-010092-uftc8inx 1747 5 02 02 CD cord-010092-uftc8inx 1747 6 SUPERDONORS SUPERDONORS NNP cord-010092-uftc8inx 1747 7 -GENETIC -GENETIC NNP cord-010092-uftc8inx 1747 8 RISK risk NN cord-010092-uftc8inx 1747 9 PROFILE profile NN cord-010092-uftc8inx 1747 10 AND and CC cord-010092-uftc8inx 1747 11 RISK risk NN cord-010092-uftc8inx 1747 12 OF of IN cord-010092-uftc8inx 1747 13 LOW low JJ cord-010092-uftc8inx 1747 14 HEMOGLOBIN hemoglobin NN cord-010092-uftc8inx 1747 15 DEFERRAL deferral NN cord-010092-uftc8inx 1747 16 Background background NN cord-010092-uftc8inx 1747 17 : : : cord-010092-uftc8inx 1748 1 No no DT cord-010092-uftc8inx 1748 2 reliable reliable JJ cord-010092-uftc8inx 1748 3 method method NN cord-010092-uftc8inx 1748 4 exists exist VBZ cord-010092-uftc8inx 1748 5 for for IN cord-010092-uftc8inx 1748 6 stratifying stratify VBG cord-010092-uftc8inx 1748 7 new new JJ cord-010092-uftc8inx 1748 8 blood blood NN cord-010092-uftc8inx 1748 9 donors donor NNS cord-010092-uftc8inx 1748 10 into into IN cord-010092-uftc8inx 1748 11 those those DT cord-010092-uftc8inx 1748 12 who who WP cord-010092-uftc8inx 1748 13 can can MD cord-010092-uftc8inx 1748 14 maintain maintain VB cord-010092-uftc8inx 1748 15 sufficient sufficient JJ cord-010092-uftc8inx 1748 16 hemoglobin hemoglobin NN cord-010092-uftc8inx 1748 17 ( ( -LRB- cord-010092-uftc8inx 1748 18 Hb Hb NNP cord-010092-uftc8inx 1748 19 ) ) -RRB- cord-010092-uftc8inx 1748 20 levels level NNS cord-010092-uftc8inx 1748 21 and and CC cord-010092-uftc8inx 1748 22 those those DT cord-010092-uftc8inx 1748 23 who who WP cord-010092-uftc8inx 1748 24 will will MD cord-010092-uftc8inx 1748 25 be be VB cord-010092-uftc8inx 1748 26 deferred defer VBN cord-010092-uftc8inx 1748 27 because because IN cord-010092-uftc8inx 1748 28 of of IN cord-010092-uftc8inx 1748 29 a a DT cord-010092-uftc8inx 1748 30 low low JJ cord-010092-uftc8inx 1748 31 Hb Hb NNP cord-010092-uftc8inx 1748 32 ( ( -LRB- cord-010092-uftc8inx 1748 33 < < NNP cord-010092-uftc8inx 1748 34 7.8 7.8 CD cord-010092-uftc8inx 1748 35 mmol mmol JJ cord-010092-uftc8inx 1748 36 / / SYM cord-010092-uftc8inx 1748 37 l l NN cord-010092-uftc8inx 1748 38 [ [ -LRB- cord-010092-uftc8inx 1748 39 < < XX cord-010092-uftc8inx 1748 40 12.57 12.57 CD cord-010092-uftc8inx 1748 41 g g NNP cord-010092-uftc8inx 1748 42 / / SYM cord-010092-uftc8inx 1748 43 dl dl NN cord-010092-uftc8inx 1748 44 ] ] -RRB- cord-010092-uftc8inx 1748 45 for for IN cord-010092-uftc8inx 1748 46 women woman NNS cord-010092-uftc8inx 1748 47 and and CC cord-010092-uftc8inx 1748 48 < < XX cord-010092-uftc8inx 1748 49 8.4 8.4 CD cord-010092-uftc8inx 1748 50 mmol mmol NNP cord-010092-uftc8inx 1748 51 / / SYM cord-010092-uftc8inx 1748 52 l l NN cord-010092-uftc8inx 1748 53 [ [ -LRB- cord-010092-uftc8inx 1748 54 < < XX cord-010092-uftc8inx 1748 55 13.54 13.54 CD cord-010092-uftc8inx 1748 56 g g NN cord-010092-uftc8inx 1748 57 / / SYM cord-010092-uftc8inx 1748 58 dl dl NN cord-010092-uftc8inx 1748 59 ] ] -RRB- cord-010092-uftc8inx 1748 60 for for IN cord-010092-uftc8inx 1748 61 men man NNS cord-010092-uftc8inx 1748 62 ) ) -RRB- cord-010092-uftc8inx 1748 63 . . . cord-010092-uftc8inx 1749 1 Polygenic polygenic JJ cord-010092-uftc8inx 1749 2 risk risk NN cord-010092-uftc8inx 1749 3 scores score NNS cord-010092-uftc8inx 1749 4 ( ( -LRB- cord-010092-uftc8inx 1749 5 PRSs prs NNS cord-010092-uftc8inx 1749 6 ) ) -RRB- cord-010092-uftc8inx 1749 7 have have VBP cord-010092-uftc8inx 1749 8 shown show VBN cord-010092-uftc8inx 1749 9 great great JJ cord-010092-uftc8inx 1749 10 promise promise NN cord-010092-uftc8inx 1749 11 in in IN cord-010092-uftc8inx 1749 12 predicting predict VBG cord-010092-uftc8inx 1749 13 complex complex JJ cord-010092-uftc8inx 1749 14 disease disease NN cord-010092-uftc8inx 1749 15 risk risk NN cord-010092-uftc8inx 1749 16 . . . cord-010092-uftc8inx 1750 1 PRSs PRSs NNP cord-010092-uftc8inx 1750 2 could could MD cord-010092-uftc8inx 1750 3 also also RB cord-010092-uftc8inx 1750 4 prove prove VB cord-010092-uftc8inx 1750 5 useful useful JJ cord-010092-uftc8inx 1750 6 for for IN cord-010092-uftc8inx 1750 7 identification identification NN cord-010092-uftc8inx 1750 8 of of IN cord-010092-uftc8inx 1750 9 donors donor NNS cord-010092-uftc8inx 1750 10 genetically genetically RB cord-010092-uftc8inx 1750 11 predisposed predisposed JJ cord-010092-uftc8inx 1750 12 to to IN cord-010092-uftc8inx 1750 13 low low JJ cord-010092-uftc8inx 1750 14 Hb Hb NNP cord-010092-uftc8inx 1750 15 levels level NNS cord-010092-uftc8inx 1750 16 , , , cord-010092-uftc8inx 1750 17 and and CC cord-010092-uftc8inx 1750 18 , , , cord-010092-uftc8inx 1750 19 thus thus RB cord-010092-uftc8inx 1750 20 , , , cord-010092-uftc8inx 1750 21 to to IN cord-010092-uftc8inx 1750 22 an an DT cord-010092-uftc8inx 1750 23 increased increase VBN cord-010092-uftc8inx 1750 24 risk risk NN cord-010092-uftc8inx 1750 25 of of IN cord-010092-uftc8inx 1750 26 deferral deferral NN cord-010092-uftc8inx 1750 27 . . . cord-010092-uftc8inx 1751 1 Aims aim VBZ cord-010092-uftc8inx 1751 2 : : : cord-010092-uftc8inx 1752 1 The the DT cord-010092-uftc8inx 1752 2 objective objective NN cord-010092-uftc8inx 1752 3 of of IN cord-010092-uftc8inx 1752 4 the the DT cord-010092-uftc8inx 1752 5 study study NN cord-010092-uftc8inx 1752 6 was be VBD cord-010092-uftc8inx 1752 7 to to TO cord-010092-uftc8inx 1752 8 evaluate evaluate VB cord-010092-uftc8inx 1752 9 the the DT cord-010092-uftc8inx 1752 10 association association NN cord-010092-uftc8inx 1752 11 between between IN cord-010092-uftc8inx 1752 12 PRS PRS NNP cord-010092-uftc8inx 1752 13 ( ( -LRB- cord-010092-uftc8inx 1752 14 modelled model VBN cord-010092-uftc8inx 1752 15 to to TO cord-010092-uftc8inx 1752 16 predict predict VB cord-010092-uftc8inx 1752 17 Hb Hb NNP cord-010092-uftc8inx 1752 18 level level NN cord-010092-uftc8inx 1752 19 as as IN cord-010092-uftc8inx 1752 20 a a DT cord-010092-uftc8inx 1752 21 quantitative quantitative JJ cord-010092-uftc8inx 1752 22 trait trait NN cord-010092-uftc8inx 1752 23 ) ) -RRB- cord-010092-uftc8inx 1752 24 and and CC cord-010092-uftc8inx 1752 25 risk risk NN cord-010092-uftc8inx 1752 26 of of IN cord-010092-uftc8inx 1752 27 deferral deferral NN cord-010092-uftc8inx 1752 28 as as IN cord-010092-uftc8inx 1752 29 a a DT cord-010092-uftc8inx 1752 30 binary binary JJ cord-010092-uftc8inx 1752 31 outcome outcome NN cord-010092-uftc8inx 1752 32 . . . cord-010092-uftc8inx 1753 1 Methods method NNS cord-010092-uftc8inx 1753 2 : : : cord-010092-uftc8inx 1754 1 The the DT cord-010092-uftc8inx 1754 2 Danish Danish NNP cord-010092-uftc8inx 1754 3 Blood Blood NNP cord-010092-uftc8inx 1754 4 Donor Donor NNP cord-010092-uftc8inx 1754 5 Study Study NNP cord-010092-uftc8inx 1754 6 ( ( -LRB- cord-010092-uftc8inx 1754 7 DBDS DBDS NNP cord-010092-uftc8inx 1754 8 ) ) -RRB- cord-010092-uftc8inx 1754 9 is be VBZ cord-010092-uftc8inx 1754 10 an an DT cord-010092-uftc8inx 1754 11 ongoing ongoing JJ cord-010092-uftc8inx 1754 12 nationwide nationwide JJ cord-010092-uftc8inx 1754 13 blood blood NN cord-010092-uftc8inx 1754 14 donor donor NN cord-010092-uftc8inx 1754 15 cohort cohort NN cord-010092-uftc8inx 1754 16 since since IN cord-010092-uftc8inx 1754 17 2010 2010 CD cord-010092-uftc8inx 1754 18 with with IN cord-010092-uftc8inx 1754 19 more more JJR cord-010092-uftc8inx 1754 20 than than IN cord-010092-uftc8inx 1754 21 110,000 110,000 CD cord-010092-uftc8inx 1754 22 participants participant NNS cord-010092-uftc8inx 1754 23 . . . cord-010092-uftc8inx 1755 1 Extensive extensive JJ cord-010092-uftc8inx 1755 2 genotyping genotyping NN cord-010092-uftc8inx 1755 3 has have VBZ cord-010092-uftc8inx 1755 4 been be VBN cord-010092-uftc8inx 1755 5 performed perform VBN cord-010092-uftc8inx 1755 6 on on IN cord-010092-uftc8inx 1755 7 approximately approximately RB cord-010092-uftc8inx 1755 8 72,000 72,000 CD cord-010092-uftc8inx 1755 9 DBDS DBDS NNP cord-010092-uftc8inx 1755 10 participants participant NNS cord-010092-uftc8inx 1755 11 using use VBG cord-010092-uftc8inx 1755 12 the the DT cord-010092-uftc8inx 1755 13 Infinium Infinium NNP cord-010092-uftc8inx 1755 14 Global Global NNP cord-010092-uftc8inx 1755 15 Screening Screening NNP cord-010092-uftc8inx 1755 16 Array Array NNP cord-010092-uftc8inx 1755 17 ( ( -LRB- cord-010092-uftc8inx 1755 18 Illumina Illumina NNP cord-010092-uftc8inx 1755 19 â â CD cord-010092-uftc8inx 1755 20 ) ) -RRB- cord-010092-uftc8inx 1755 21 and and CC cord-010092-uftc8inx 1755 22 extended extend VBN cord-010092-uftc8inx 1755 23 by by IN cord-010092-uftc8inx 1755 24 use use NN cord-010092-uftc8inx 1755 25 of of IN cord-010092-uftc8inx 1755 26 imputing impute VBG cord-010092-uftc8inx 1755 27 based base VBN cord-010092-uftc8inx 1755 28 on on IN cord-010092-uftc8inx 1755 29 the the DT cord-010092-uftc8inx 1755 30 pan pan JJ cord-010092-uftc8inx 1755 31 - - JJ cord-010092-uftc8inx 1755 32 Scandinavian scandinavian JJ cord-010092-uftc8inx 1755 33 reference reference NN cord-010092-uftc8inx 1755 34 genome genome NN cord-010092-uftc8inx 1755 35 . . . cord-010092-uftc8inx 1756 1 Based base VBN cord-010092-uftc8inx 1756 2 on on IN cord-010092-uftc8inx 1756 3 Hb Hb NNP cord-010092-uftc8inx 1756 4 and and CC cord-010092-uftc8inx 1756 5 genetic genetic JJ cord-010092-uftc8inx 1756 6 data datum NNS cord-010092-uftc8inx 1756 7 on on IN cord-010092-uftc8inx 1756 8 more more JJR cord-010092-uftc8inx 1756 9 than than IN cord-010092-uftc8inx 1756 10 150,000 150,000 CD cord-010092-uftc8inx 1756 11 Icelandic icelandic JJ cord-010092-uftc8inx 1756 12 individuals individual NNS cord-010092-uftc8inx 1756 13 ( ( -LRB- cord-010092-uftc8inx 1756 14 an an DT cord-010092-uftc8inx 1756 15 independent independent JJ cord-010092-uftc8inx 1756 16 discovery discovery NN cord-010092-uftc8inx 1756 17 cohort cohort NN cord-010092-uftc8inx 1756 18 ) ) -RRB- cord-010092-uftc8inx 1756 19 , , , cord-010092-uftc8inx 1756 20 we -PRON- PRP cord-010092-uftc8inx 1756 21 constructed construct VBD cord-010092-uftc8inx 1756 22 9 9 CD cord-010092-uftc8inx 1756 23 different different JJ cord-010092-uftc8inx 1756 24 weighted weighted JJ cord-010092-uftc8inx 1756 25 PRSs prs NNS cord-010092-uftc8inx 1756 26 for for IN cord-010092-uftc8inx 1756 27 individuals individual NNS cord-010092-uftc8inx 1756 28 from from IN cord-010092-uftc8inx 1756 29 DBDS DBDS NNP cord-010092-uftc8inx 1756 30 . . . cord-010092-uftc8inx 1757 1 Information information NN cord-010092-uftc8inx 1757 2 on on IN cord-010092-uftc8inx 1757 3 the the DT cord-010092-uftc8inx 1757 4 donors donor NNS cord-010092-uftc8inx 1757 5 ' ' POS cord-010092-uftc8inx 1757 6 whole whole JJ cord-010092-uftc8inx 1757 7 blood blood NN cord-010092-uftc8inx 1757 8 donations donation NNS cord-010092-uftc8inx 1757 9 following follow VBG cord-010092-uftc8inx 1757 10 inclusion inclusion NN cord-010092-uftc8inx 1757 11 into into IN cord-010092-uftc8inx 1757 12 DBDS DBDS NNP cord-010092-uftc8inx 1757 13 unto unto IN cord-010092-uftc8inx 1757 14 end end NN cord-010092-uftc8inx 1757 15 of of IN cord-010092-uftc8inx 1757 16 2017 2017 CD cord-010092-uftc8inx 1757 17 was be VBD cord-010092-uftc8inx 1757 18 obtained obtain VBN cord-010092-uftc8inx 1757 19 from from IN cord-010092-uftc8inx 1757 20 a a DT cord-010092-uftc8inx 1757 21 nationwide nationwide JJ cord-010092-uftc8inx 1757 22 donation donation NN cord-010092-uftc8inx 1757 23 database database NN cord-010092-uftc8inx 1757 24 , , , cord-010092-uftc8inx 1757 25 SCANDAT SCANDAT NNP cord-010092-uftc8inx 1757 26 . . . cord-010092-uftc8inx 1758 1 The the DT cord-010092-uftc8inx 1758 2 best good JJS cord-010092-uftc8inx 1758 3 predictor predictor NN cord-010092-uftc8inx 1758 4 of of IN cord-010092-uftc8inx 1758 5 Hb Hb NNP cord-010092-uftc8inx 1758 6 among among IN cord-010092-uftc8inx 1758 7 the the DT cord-010092-uftc8inx 1758 8 nine nine CD cord-010092-uftc8inx 1758 9 PRSs prs NNS cord-010092-uftc8inx 1758 10 was be VBD cord-010092-uftc8inx 1758 11 chosen choose VBN cord-010092-uftc8inx 1758 12 and and CC cord-010092-uftc8inx 1758 13 used use VBN cord-010092-uftc8inx 1758 14 in in IN cord-010092-uftc8inx 1758 15 all all DT cord-010092-uftc8inx 1758 16 subsequent subsequent JJ cord-010092-uftc8inx 1758 17 analyses analysis NNS cord-010092-uftc8inx 1758 18 . . . cord-010092-uftc8inx 1759 1 We -PRON- PRP cord-010092-uftc8inx 1759 2 performed perform VBD cord-010092-uftc8inx 1759 3 multilevel multilevel JJ cord-010092-uftc8inx 1759 4 mixed mixed JJ cord-010092-uftc8inx 1759 5 - - HYPH cord-010092-uftc8inx 1759 6 effects effect NNS cord-010092-uftc8inx 1759 7 linear linear JJ cord-010092-uftc8inx 1759 8 regression regression NN cord-010092-uftc8inx 1759 9 analysis analysis NN cord-010092-uftc8inx 1759 10 with with IN cord-010092-uftc8inx 1759 11 Hb Hb NNP cord-010092-uftc8inx 1759 12 as as IN cord-010092-uftc8inx 1759 13 outcome outcome NN cord-010092-uftc8inx 1759 14 , , , cord-010092-uftc8inx 1759 15 and and CC cord-010092-uftc8inx 1759 16 PRS PRS NNP cord-010092-uftc8inx 1759 17 as as IN cord-010092-uftc8inx 1759 18 factorized factorized JJ cord-010092-uftc8inx 1759 19 explanatory explanatory JJ cord-010092-uftc8inx 1759 20 variable variable NN cord-010092-uftc8inx 1759 21 with with IN cord-010092-uftc8inx 1759 22 cutoffs cutoff NNS cord-010092-uftc8inx 1759 23 at at IN cord-010092-uftc8inx 1759 24 5 5 CD cord-010092-uftc8inx 1759 25 , , , cord-010092-uftc8inx 1759 26 10 10 CD cord-010092-uftc8inx 1759 27 , , , cord-010092-uftc8inx 1759 28 25 25 CD cord-010092-uftc8inx 1759 29 , , , cord-010092-uftc8inx 1759 30 40 40 CD cord-010092-uftc8inx 1759 31 , , , cord-010092-uftc8inx 1759 32 60 60 CD cord-010092-uftc8inx 1759 33 , , , cord-010092-uftc8inx 1759 34 75 75 CD cord-010092-uftc8inx 1759 35 , , , cord-010092-uftc8inx 1759 36 90 90 CD cord-010092-uftc8inx 1759 37 , , , cord-010092-uftc8inx 1759 38 and and CC cord-010092-uftc8inx 1759 39 95 95 CD cord-010092-uftc8inx 1759 40 th th XX cord-010092-uftc8inx 1759 41 percentiles percentile NNS cord-010092-uftc8inx 1759 42 , , , cord-010092-uftc8inx 1759 43 respectively respectively RB cord-010092-uftc8inx 1759 44 . . . cord-010092-uftc8inx 1760 1 Moreover moreover RB cord-010092-uftc8inx 1760 2 , , , cord-010092-uftc8inx 1760 3 the the DT cord-010092-uftc8inx 1760 4 models model NNS cord-010092-uftc8inx 1760 5 had have VBD cord-010092-uftc8inx 1760 6 a a DT cord-010092-uftc8inx 1760 7 two two CD cord-010092-uftc8inx 1760 8 - - HYPH cord-010092-uftc8inx 1760 9 level level NN cord-010092-uftc8inx 1760 10 clustering clustering NN cord-010092-uftc8inx 1760 11 on on IN cord-010092-uftc8inx 1760 12 donor donor NN cord-010092-uftc8inx 1760 13 ID id NN cord-010092-uftc8inx 1760 14 and and CC cord-010092-uftc8inx 1760 15 donation donation NN cord-010092-uftc8inx 1760 16 site site NN cord-010092-uftc8inx 1760 17 and and CC cord-010092-uftc8inx 1760 18 an an DT cord-010092-uftc8inx 1760 19 ID ID NNP cord-010092-uftc8inx 1760 20 - - HYPH cord-010092-uftc8inx 1760 21 specific specific JJ cord-010092-uftc8inx 1760 22 random random JJ cord-010092-uftc8inx 1760 23 intercept intercept NN cord-010092-uftc8inx 1760 24 ; ; : cord-010092-uftc8inx 1760 25 and and CC cord-010092-uftc8inx 1760 26 further further RB cord-010092-uftc8inx 1760 27 adjusted adjust VBN cord-010092-uftc8inx 1760 28 for for IN cord-010092-uftc8inx 1760 29 : : : cord-010092-uftc8inx 1760 30 sex(binary sex(binary LS cord-010092-uftc8inx 1760 31 ) ) -RRB- cord-010092-uftc8inx 1760 32 , , , cord-010092-uftc8inx 1760 33 age(continuous age(continuous NNP cord-010092-uftc8inx 1760 34 ) ) -RRB- cord-010092-uftc8inx 1760 35 , , , cord-010092-uftc8inx 1760 36 year year NN cord-010092-uftc8inx 1760 37 of of IN cord-010092-uftc8inx 1760 38 donation(factorized donation(factorized NNP cord-010092-uftc8inx 1760 39 ) ) -RRB- cord-010092-uftc8inx 1760 40 , , , cord-010092-uftc8inx 1760 41 and and CC cord-010092-uftc8inx 1760 42 time time NN cord-010092-uftc8inx 1760 43 since since IN cord-010092-uftc8inx 1760 44 last last JJ cord-010092-uftc8inx 1760 45 donation donation NN cord-010092-uftc8inx 1760 46 ( ( -LRB- cord-010092-uftc8inx 1760 47 continuous continuous JJ cord-010092-uftc8inx 1760 48 ) ) -RRB- cord-010092-uftc8inx 1760 49 . . . cord-010092-uftc8inx 1761 1 Lastly lastly RB cord-010092-uftc8inx 1761 2 , , , cord-010092-uftc8inx 1761 3 risk risk NN cord-010092-uftc8inx 1761 4 of of IN cord-010092-uftc8inx 1761 5 deferral deferral NN cord-010092-uftc8inx 1761 6 was be VBD cord-010092-uftc8inx 1761 7 evaluated evaluate VBN cord-010092-uftc8inx 1761 8 in in IN cord-010092-uftc8inx 1761 9 random random JJ cord-010092-uftc8inx 1761 10 effects effect NNS cord-010092-uftc8inx 1761 11 logit logit NN cord-010092-uftc8inx 1761 12 models model NNS cord-010092-uftc8inx 1761 13 with with IN cord-010092-uftc8inx 1761 14 similar similar JJ cord-010092-uftc8inx 1761 15 covariables covariable NNS cord-010092-uftc8inx 1761 16 and and CC cord-010092-uftc8inx 1761 17 clustering clustering NN cord-010092-uftc8inx 1761 18 structure structure NN cord-010092-uftc8inx 1761 19 . . . cord-010092-uftc8inx 1762 1 Results result NNS cord-010092-uftc8inx 1762 2 : : : cord-010092-uftc8inx 1763 1 Mean mean JJ cord-010092-uftc8inx 1763 2 number number NN cord-010092-uftc8inx 1763 3 of of IN cord-010092-uftc8inx 1763 4 donations donation NNS cord-010092-uftc8inx 1763 5 per per IN cord-010092-uftc8inx 1763 6 donor donor NN cord-010092-uftc8inx 1763 7 after after IN cord-010092-uftc8inx 1763 8 DBDS DBDS NNP cord-010092-uftc8inx 1763 9 inclusion inclusion NN cord-010092-uftc8inx 1763 10 was be VBD cord-010092-uftc8inx 1763 11 6.9 6.9 CD cord-010092-uftc8inx 1763 12 donations donation NNS cord-010092-uftc8inx 1763 13 . . . cord-010092-uftc8inx 1764 1 Generally generally RB cord-010092-uftc8inx 1764 2 , , , cord-010092-uftc8inx 1764 3 we -PRON- PRP cord-010092-uftc8inx 1764 4 observed observe VBD cord-010092-uftc8inx 1764 5 a a DT cord-010092-uftc8inx 1764 6 statistically statistically RB cord-010092-uftc8inx 1764 7 significant significant JJ cord-010092-uftc8inx 1764 8 positive positive JJ cord-010092-uftc8inx 1764 9 association association NN cord-010092-uftc8inx 1764 10 between between IN cord-010092-uftc8inx 1764 11 PRS(Hb PRS(Hb NNP cord-010092-uftc8inx 1764 12 ) ) -RRB- cord-010092-uftc8inx 1764 13 and and CC cord-010092-uftc8inx 1764 14 current current JJ cord-010092-uftc8inx 1764 15 Hb Hb NNP cord-010092-uftc8inx 1764 16 levels level NNS cord-010092-uftc8inx 1764 17 . . . cord-010092-uftc8inx 1765 1 Compared compare VBN cord-010092-uftc8inx 1765 2 with with IN cord-010092-uftc8inx 1765 3 donors donor NNS cord-010092-uftc8inx 1765 4 in in IN cord-010092-uftc8inx 1765 5 the the DT cord-010092-uftc8inx 1765 6 40 40 CD cord-010092-uftc8inx 1765 7 - - SYM cord-010092-uftc8inx 1765 8 60 60 CD cord-010092-uftc8inx 1765 9 PRS PRS NNP cord-010092-uftc8inx 1765 10 percentile percentile NN cord-010092-uftc8inx 1765 11 group group NN cord-010092-uftc8inx 1765 12 , , , cord-010092-uftc8inx 1765 13 donors donor NNS cord-010092-uftc8inx 1765 14 below below IN cord-010092-uftc8inx 1765 15 the the DT cord-010092-uftc8inx 1765 16 5 5 CD cord-010092-uftc8inx 1765 17 th th XX cord-010092-uftc8inx 1765 18 percentile percentile NN cord-010092-uftc8inx 1765 19 had have VBD cord-010092-uftc8inx 1765 20 lower low JJR cord-010092-uftc8inx 1766 1 ( ( -LRB- cord-010092-uftc8inx 1766 2 -0.23 -0.23 CD cord-010092-uftc8inx 1766 3 Hb Hb NNP cord-010092-uftc8inx 1766 4 mmol mmol NNP cord-010092-uftc8inx 1766 5 / / SYM cord-010092-uftc8inx 1766 6 L L NNP cord-010092-uftc8inx 1766 7 ( ( -LRB- cord-010092-uftc8inx 1766 8 95 95 CD cord-010092-uftc8inx 1766 9 % % NN cord-010092-uftc8inx 1766 10 CI ci NN cord-010092-uftc8inx 1766 11 : : : cord-010092-uftc8inx 1766 12 -0.25 -0.25 NNS cord-010092-uftc8inx 1766 13 ; ; : cord-010092-uftc8inx 1766 14 -0.21 -0.21 ADD cord-010092-uftc8inx 1766 15 ) ) -RRB- cord-010092-uftc8inx 1766 16 ) ) -RRB- cord-010092-uftc8inx 1766 17 and and CC cord-010092-uftc8inx 1766 18 donors donor NNS cord-010092-uftc8inx 1766 19 above above IN cord-010092-uftc8inx 1766 20 the the DT cord-010092-uftc8inx 1766 21 95 95 CD cord-010092-uftc8inx 1766 22 th th XX cord-010092-uftc8inx 1766 23 percentile percentile NN cord-010092-uftc8inx 1766 24 higher high JJR cord-010092-uftc8inx 1767 1 ( ( -LRB- cord-010092-uftc8inx 1767 2 +0.19 +0.19 NNP cord-010092-uftc8inx 1767 3 Hb Hb NNP cord-010092-uftc8inx 1767 4 mmol mmol NN cord-010092-uftc8inx 1767 5 / / SYM cord-010092-uftc8inx 1767 6 L L NNP cord-010092-uftc8inx 1767 7 ( ( -LRB- cord-010092-uftc8inx 1767 8 95 95 CD cord-010092-uftc8inx 1767 9 % % NN cord-010092-uftc8inx 1767 10 CI ci NN cord-010092-uftc8inx 1767 11 : : : cord-010092-uftc8inx 1767 12 0.18 0.18 CD cord-010092-uftc8inx 1767 13 ; ; : cord-010092-uftc8inx 1767 14 0.21 0.21 CD cord-010092-uftc8inx 1767 15 ) ) -RRB- cord-010092-uftc8inx 1768 1 Hb Hb NNP cord-010092-uftc8inx 1768 2 levels level NNS cord-010092-uftc8inx 1768 3 . . . cord-010092-uftc8inx 1769 1 In in IN cord-010092-uftc8inx 1769 2 the the DT cord-010092-uftc8inx 1769 3 random random JJ cord-010092-uftc8inx 1769 4 effects effect NNS cord-010092-uftc8inx 1769 5 logit logit NN cord-010092-uftc8inx 1769 6 models model NNS cord-010092-uftc8inx 1769 7 we -PRON- PRP cord-010092-uftc8inx 1769 8 observed observe VBD cord-010092-uftc8inx 1769 9 a a DT cord-010092-uftc8inx 1769 10 marked marked JJ cord-010092-uftc8inx 1769 11 increase increase NN cord-010092-uftc8inx 1769 12 in in IN cord-010092-uftc8inx 1769 13 deferral deferral NN cord-010092-uftc8inx 1769 14 risk risk NN cord-010092-uftc8inx 1769 15 with with IN cord-010092-uftc8inx 1769 16 decreasing decrease VBG cord-010092-uftc8inx 1769 17 PRS PRS NNP cord-010092-uftc8inx 1769 18 percentile percentile JJ cord-010092-uftc8inx 1769 19 strata strata NN cord-010092-uftc8inx 1769 20 . . . cord-010092-uftc8inx 1770 1 With with IN cord-010092-uftc8inx 1770 2 the the DT cord-010092-uftc8inx 1770 3 40 40 CD cord-010092-uftc8inx 1770 4 - - SYM cord-010092-uftc8inx 1770 5 60 60 CD cord-010092-uftc8inx 1770 6 PRS PRS NNP cord-010092-uftc8inx 1770 7 percentile percentile NN cord-010092-uftc8inx 1770 8 stratum stratum NN cord-010092-uftc8inx 1770 9 as as IN cord-010092-uftc8inx 1770 10 reference reference NN cord-010092-uftc8inx 1770 11 , , , cord-010092-uftc8inx 1770 12 donors donor NNS cord-010092-uftc8inx 1770 13 below below IN cord-010092-uftc8inx 1770 14 the the DT cord-010092-uftc8inx 1770 15 5 5 CD cord-010092-uftc8inx 1770 16 th th XX cord-010092-uftc8inx 1770 17 percentile percentile NN cord-010092-uftc8inx 1770 18 and and CC cord-010092-uftc8inx 1770 19 donors donor NNS cord-010092-uftc8inx 1770 20 above above IN cord-010092-uftc8inx 1770 21 the the DT cord-010092-uftc8inx 1770 22 95 95 CD cord-010092-uftc8inx 1770 23 th th XX cord-010092-uftc8inx 1770 24 percentile percentile NN cord-010092-uftc8inx 1770 25 had have VBD cord-010092-uftc8inx 1770 26 odds odd NNS cord-010092-uftc8inx 1770 27 ratios ratio NNS cord-010092-uftc8inx 1770 28 of of IN cord-010092-uftc8inx 1770 29 deferral deferral NN cord-010092-uftc8inx 1770 30 of of IN cord-010092-uftc8inx 1770 31 OR or NN cord-010092-uftc8inx 1771 1 = = NFP cord-010092-uftc8inx 1771 2 2.58 2.58 CD cord-010092-uftc8inx 1772 1 ( ( -LRB- cord-010092-uftc8inx 1772 2 95 95 CD cord-010092-uftc8inx 1772 3 % % NN cord-010092-uftc8inx 1772 4 CI ci NN cord-010092-uftc8inx 1772 5 : : : cord-010092-uftc8inx 1772 6 2.27 2.27 CD cord-010092-uftc8inx 1772 7 ; ; : cord-010092-uftc8inx 1772 8 2.93 2.93 CD cord-010092-uftc8inx 1772 9 ) ) -RRB- cord-010092-uftc8inx 1772 10 and and CC cord-010092-uftc8inx 1772 11 OR or CC cord-010092-uftc8inx 1773 1 = = SYM cord-010092-uftc8inx 1773 2 0.46 0.46 CD cord-010092-uftc8inx 1774 1 ( ( -LRB- cord-010092-uftc8inx 1774 2 95 95 CD cord-010092-uftc8inx 1774 3 % % NN cord-010092-uftc8inx 1774 4 CI ci NN cord-010092-uftc8inx 1774 5 : : : cord-010092-uftc8inx 1774 6 0.39 0.39 CD cord-010092-uftc8inx 1774 7 ; ; : cord-010092-uftc8inx 1774 8 0.54 0.54 CD cord-010092-uftc8inx 1774 9 ) ) -RRB- cord-010092-uftc8inx 1774 10 , , , cord-010092-uftc8inx 1774 11 respectively respectively RB cord-010092-uftc8inx 1774 12 . . . cord-010092-uftc8inx 1775 1 Summary Summary NNP cord-010092-uftc8inx 1775 2 / / SYM cord-010092-uftc8inx 1775 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 1775 4 : : : cord-010092-uftc8inx 1776 1 We -PRON- PRP cord-010092-uftc8inx 1776 2 found find VBD cord-010092-uftc8inx 1776 3 a a DT cord-010092-uftc8inx 1776 4 statistically statistically RB cord-010092-uftc8inx 1776 5 significant significant JJ cord-010092-uftc8inx 1776 6 positive positive JJ cord-010092-uftc8inx 1776 7 association association NN cord-010092-uftc8inx 1776 8 between between IN cord-010092-uftc8inx 1776 9 PRS(Hb PRS(Hb NNP cord-010092-uftc8inx 1776 10 ) ) -RRB- cord-010092-uftc8inx 1776 11 and and CC cord-010092-uftc8inx 1776 12 Hb Hb NNP cord-010092-uftc8inx 1776 13 levels level NNS cord-010092-uftc8inx 1776 14 and and CC cord-010092-uftc8inx 1776 15 a a DT cord-010092-uftc8inx 1776 16 markedly markedly RB cord-010092-uftc8inx 1776 17 increased increase VBN cord-010092-uftc8inx 1776 18 risk risk NN cord-010092-uftc8inx 1776 19 of of IN cord-010092-uftc8inx 1776 20 deferral deferral NN cord-010092-uftc8inx 1776 21 with with IN cord-010092-uftc8inx 1776 22 decreasing decrease VBG cord-010092-uftc8inx 1776 23 PRS(Hb PRS(Hb NNP cord-010092-uftc8inx 1776 24 ) ) -RRB- cord-010092-uftc8inx 1776 25 . . . cord-010092-uftc8inx 1777 1 From from IN cord-010092-uftc8inx 1777 2 a a DT cord-010092-uftc8inx 1777 3 scientific scientific JJ cord-010092-uftc8inx 1777 4 point point NN cord-010092-uftc8inx 1777 5 of of IN cord-010092-uftc8inx 1777 6 view view NN cord-010092-uftc8inx 1777 7 , , , cord-010092-uftc8inx 1777 8 it -PRON- PRP cord-010092-uftc8inx 1777 9 is be VBZ cord-010092-uftc8inx 1777 10 unsurprising unsurprising JJ cord-010092-uftc8inx 1777 11 that that IN cord-010092-uftc8inx 1777 12 a a DT cord-010092-uftc8inx 1777 13 genetic genetic JJ cord-010092-uftc8inx 1777 14 score score NN cord-010092-uftc8inx 1777 15 for for IN cord-010092-uftc8inx 1777 16 Hb Hb NNP cord-010092-uftc8inx 1777 17 from from IN cord-010092-uftc8inx 1777 18 an an DT cord-010092-uftc8inx 1777 19 independent independent JJ cord-010092-uftc8inx 1777 20 cohort cohort NN cord-010092-uftc8inx 1777 21 is be VBZ cord-010092-uftc8inx 1777 22 associated associate VBN cord-010092-uftc8inx 1777 23 with with IN cord-010092-uftc8inx 1777 24 Hb Hb NNP cord-010092-uftc8inx 1777 25 in in IN cord-010092-uftc8inx 1777 26 another another DT cord-010092-uftc8inx 1777 27 cohort cohort NN cord-010092-uftc8inx 1777 28 . . . cord-010092-uftc8inx 1778 1 However however RB cord-010092-uftc8inx 1778 2 , , , cord-010092-uftc8inx 1778 3 from from IN cord-010092-uftc8inx 1778 4 a a DT cord-010092-uftc8inx 1778 5 practical practical JJ cord-010092-uftc8inx 1778 6 perspective perspective NN cord-010092-uftc8inx 1778 7 , , , cord-010092-uftc8inx 1778 8 PRSs prs NNS cord-010092-uftc8inx 1778 9 may may MD cord-010092-uftc8inx 1778 10 be be VB cord-010092-uftc8inx 1778 11 the the DT cord-010092-uftc8inx 1778 12 first first JJ cord-010092-uftc8inx 1778 13 step step NN cord-010092-uftc8inx 1778 14 in in IN cord-010092-uftc8inx 1778 15 a a DT cord-010092-uftc8inx 1778 16 personalized personalized JJ cord-010092-uftc8inx 1778 17 donation donation NN cord-010092-uftc8inx 1778 18 approach approach NN cord-010092-uftc8inx 1778 19 to to IN cord-010092-uftc8inx 1778 20 donors donor NNS cord-010092-uftc8inx 1778 21 and and CC cord-010092-uftc8inx 1778 22 their -PRON- PRP$ cord-010092-uftc8inx 1778 23 risk risk NN cord-010092-uftc8inx 1778 24 of of IN cord-010092-uftc8inx 1778 25 deferral deferral NN cord-010092-uftc8inx 1778 26 . . . cord-010092-uftc8inx 1779 1 Background background NN cord-010092-uftc8inx 1779 2 : : : cord-010092-uftc8inx 1780 1 Individually individually RB cord-010092-uftc8inx 1780 2 calibrated calibrate VBN cord-010092-uftc8inx 1780 3 inter inter JJ cord-010092-uftc8inx 1780 4 - - JJ cord-010092-uftc8inx 1780 5 donation donation NN cord-010092-uftc8inx 1780 6 intervals interval NNS cord-010092-uftc8inx 1780 7 for for IN cord-010092-uftc8inx 1780 8 repeat repeat NN cord-010092-uftc8inx 1780 9 blood blood NN cord-010092-uftc8inx 1780 10 donors donor NNS cord-010092-uftc8inx 1780 11 have have VBP cord-010092-uftc8inx 1780 12 the the DT cord-010092-uftc8inx 1780 13 potential potential NN cord-010092-uftc8inx 1780 14 to to TO cord-010092-uftc8inx 1780 15 minimize minimize VB cord-010092-uftc8inx 1780 16 the the DT cord-010092-uftc8inx 1780 17 risk risk NN cord-010092-uftc8inx 1780 18 of of IN cord-010092-uftc8inx 1780 19 iron iron NN cord-010092-uftc8inx 1780 20 related relate VBN cord-010092-uftc8inx 1780 21 adverse adverse JJ cord-010092-uftc8inx 1780 22 outcomes outcome NNS cord-010092-uftc8inx 1780 23 ( ( -LRB- cord-010092-uftc8inx 1780 24 e.g. e.g. RB cord-010092-uftc8inx 1780 25 , , , cord-010092-uftc8inx 1780 26 hemoglobin hemoglobin NN cord-010092-uftc8inx 1780 27 deferral deferral NN cord-010092-uftc8inx 1780 28 or or CC cord-010092-uftc8inx 1780 29 collecting collect VBG cord-010092-uftc8inx 1780 30 a a DT cord-010092-uftc8inx 1780 31 donation donation NN cord-010092-uftc8inx 1780 32 from from IN cord-010092-uftc8inx 1780 33 a a DT cord-010092-uftc8inx 1780 34 donor donor NN cord-010092-uftc8inx 1780 35 with with IN cord-010092-uftc8inx 1780 36 low low JJ cord-010092-uftc8inx 1780 37 or or CC cord-010092-uftc8inx 1780 38 absent absent JJ cord-010092-uftc8inx 1780 39 iron iron NN cord-010092-uftc8inx 1780 40 stores store NNS cord-010092-uftc8inx 1780 41 ) ) -RRB- cord-010092-uftc8inx 1780 42 without without IN cord-010092-uftc8inx 1780 43 unduly unduly RB cord-010092-uftc8inx 1780 44 impacting impact VBG cord-010092-uftc8inx 1780 45 the the DT cord-010092-uftc8inx 1780 46 donated donate VBN cord-010092-uftc8inx 1780 47 blood blood NN cord-010092-uftc8inx 1780 48 supply supply NN cord-010092-uftc8inx 1780 49 . . . cord-010092-uftc8inx 1781 1 Machine machine NN cord-010092-uftc8inx 1781 2 learning learning NN cord-010092-uftc8inx 1781 3 has have VBZ cord-010092-uftc8inx 1781 4 shown show VBN cord-010092-uftc8inx 1781 5 promise promise NN cord-010092-uftc8inx 1781 6 for for IN cord-010092-uftc8inx 1781 7 personalized personalized JJ cord-010092-uftc8inx 1781 8 clinical clinical JJ cord-010092-uftc8inx 1781 9 risk risk NN cord-010092-uftc8inx 1781 10 assessment assessment NN cord-010092-uftc8inx 1781 11 . . . cord-010092-uftc8inx 1782 1 Aims aim VBZ cord-010092-uftc8inx 1782 2 : : : cord-010092-uftc8inx 1783 1 Our -PRON- PRP$ cord-010092-uftc8inx 1783 2 aim aim NN cord-010092-uftc8inx 1783 3 is be VBZ cord-010092-uftc8inx 1783 4 to to TO cord-010092-uftc8inx 1783 5 use use VB cord-010092-uftc8inx 1783 6 machine machine NN cord-010092-uftc8inx 1783 7 learning learn VBG cord-010092-uftc8inx 1783 8 to to TO cord-010092-uftc8inx 1783 9 develop develop VB cord-010092-uftc8inx 1783 10 donor donor NN cord-010092-uftc8inx 1783 11 - - HYPH cord-010092-uftc8inx 1783 12 specific specific JJ cord-010092-uftc8inx 1783 13 , , , cord-010092-uftc8inx 1783 14 personalized personalized JJ cord-010092-uftc8inx 1783 15 inter inter JJ cord-010092-uftc8inx 1783 16 - - JJ cord-010092-uftc8inx 1783 17 donation donation NN cord-010092-uftc8inx 1783 18 intervals interval NNS cord-010092-uftc8inx 1783 19 that that WDT cord-010092-uftc8inx 1783 20 minimize minimize VBP cord-010092-uftc8inx 1783 21 the the DT cord-010092-uftc8inx 1783 22 risk risk NN cord-010092-uftc8inx 1783 23 of of IN cord-010092-uftc8inx 1783 24 adverse adverse JJ cord-010092-uftc8inx 1783 25 outcomes outcome NNS cord-010092-uftc8inx 1783 26 while while IN cord-010092-uftc8inx 1783 27 maintaining maintain VBG cord-010092-uftc8inx 1783 28 or or CC cord-010092-uftc8inx 1783 29 improving improve VBG cord-010092-uftc8inx 1783 30 the the DT cord-010092-uftc8inx 1783 31 adequacy adequacy NN cord-010092-uftc8inx 1783 32 of of IN cord-010092-uftc8inx 1783 33 the the DT cord-010092-uftc8inx 1783 34 donated donate VBN cord-010092-uftc8inx 1783 35 blood blood NN cord-010092-uftc8inx 1783 36 supply supply NN cord-010092-uftc8inx 1783 37 . . . cord-010092-uftc8inx 1784 1 Methods method NNS cord-010092-uftc8inx 1784 2 : : : cord-010092-uftc8inx 1784 3 Using use VBG cord-010092-uftc8inx 1784 4 a a DT cord-010092-uftc8inx 1784 5 public public JJ cord-010092-uftc8inx 1784 6 use use NN cord-010092-uftc8inx 1784 7 dataset dataset NN cord-010092-uftc8inx 1784 8 from from IN cord-010092-uftc8inx 1784 9 the the DT cord-010092-uftc8inx 1784 10 REDS REDS NNPS cord-010092-uftc8inx 1784 11 - - HYPH cord-010092-uftc8inx 1784 12 II II NNP cord-010092-uftc8inx 1784 13 Donor Donor NNP cord-010092-uftc8inx 1784 14 Iron Iron NNP cord-010092-uftc8inx 1784 15 Status status NN cord-010092-uftc8inx 1784 16 Evaluation evaluation NN cord-010092-uftc8inx 1784 17 ( ( -LRB- cord-010092-uftc8inx 1784 18 RISE RISE NNP cord-010092-uftc8inx 1784 19 ) ) -RRB- cord-010092-uftc8inx 1784 20 study study NN cord-010092-uftc8inx 1784 21 ( ( -LRB- cord-010092-uftc8inx 1784 22 Cable Cable NNP cord-010092-uftc8inx 1784 23 , , , cord-010092-uftc8inx 1784 24 Transfusion Transfusion NNP cord-010092-uftc8inx 1784 25 , , , cord-010092-uftc8inx 1784 26 2012 2012 CD cord-010092-uftc8inx 1784 27 ) ) -RRB- cord-010092-uftc8inx 1785 1 we -PRON- PRP cord-010092-uftc8inx 1785 2 defined define VBD cord-010092-uftc8inx 1785 3 donor donor NN cord-010092-uftc8inx 1785 4 profiles profile NNS cord-010092-uftc8inx 1785 5 with with IN cord-010092-uftc8inx 1785 6 physiological physiological JJ cord-010092-uftc8inx 1785 7 measures measure NNS cord-010092-uftc8inx 1785 8 including include VBG cord-010092-uftc8inx 1785 9 hemoglobin hemoglobin NN cord-010092-uftc8inx 1785 10 , , , cord-010092-uftc8inx 1785 11 ferritin ferritin NN cord-010092-uftc8inx 1785 12 and and CC cord-010092-uftc8inx 1785 13 soluble soluble JJ cord-010092-uftc8inx 1785 14 transferrin transferrin NN cord-010092-uftc8inx 1785 15 receptor receptor NN cord-010092-uftc8inx 1785 16 along along IN cord-010092-uftc8inx 1785 17 with with IN cord-010092-uftc8inx 1785 18 questionnaire questionnaire NN cord-010092-uftc8inx 1785 19 responses response NNS cord-010092-uftc8inx 1785 20 regarding regard VBG cord-010092-uftc8inx 1785 21 diet diet NN cord-010092-uftc8inx 1785 22 , , , cord-010092-uftc8inx 1785 23 reproductive reproductive JJ cord-010092-uftc8inx 1785 24 health health NN cord-010092-uftc8inx 1785 25 indicators indicator NNS cord-010092-uftc8inx 1785 26 , , , cord-010092-uftc8inx 1785 27 and and CC cord-010092-uftc8inx 1785 28 demographics demographic NNS cord-010092-uftc8inx 1785 29 . . . cord-010092-uftc8inx 1786 1 We -PRON- PRP cord-010092-uftc8inx 1786 2 used use VBD cord-010092-uftc8inx 1786 3 these these DT cord-010092-uftc8inx 1786 4 profiles profile NNS cord-010092-uftc8inx 1786 5 ( ( -LRB- cord-010092-uftc8inx 1786 6 58 58 CD cord-010092-uftc8inx 1786 7 features feature NNS cord-010092-uftc8inx 1786 8 , , , cord-010092-uftc8inx 1786 9 3,162 3,162 CD cord-010092-uftc8inx 1786 10 donations donation NNS cord-010092-uftc8inx 1786 11 from from IN cord-010092-uftc8inx 1786 12 1,025 1,025 CD cord-010092-uftc8inx 1786 13 repeat repeat NN cord-010092-uftc8inx 1786 14 donors donor NNS cord-010092-uftc8inx 1786 15 ) ) -RRB- cord-010092-uftc8inx 1786 16 and and CC cord-010092-uftc8inx 1786 17 the the DT cord-010092-uftc8inx 1786 18 time time NN cord-010092-uftc8inx 1786 19 until until IN cord-010092-uftc8inx 1786 20 the the DT cord-010092-uftc8inx 1786 21 next next JJ cord-010092-uftc8inx 1786 22 donation donation NN cord-010092-uftc8inx 1786 23 attempt attempt NN cord-010092-uftc8inx 1786 24 to to TO cord-010092-uftc8inx 1786 25 predict predict VB cord-010092-uftc8inx 1786 26 iron iron NN cord-010092-uftc8inx 1786 27 - - HYPH cord-010092-uftc8inx 1786 28 related relate VBN cord-010092-uftc8inx 1786 29 outcomes outcome NNS cord-010092-uftc8inx 1786 30 of of IN cord-010092-uftc8inx 1786 31 the the DT cord-010092-uftc8inx 1786 32 next next JJ cord-010092-uftc8inx 1786 33 donation donation NN cord-010092-uftc8inx 1786 34 attempt attempt NN cord-010092-uftc8inx 1786 35 . . . cord-010092-uftc8inx 1787 1 Possible possible JJ cord-010092-uftc8inx 1787 2 outcomes outcome NNS cord-010092-uftc8inx 1787 3 were be VBD cord-010092-uftc8inx 1787 4 no no DT cord-010092-uftc8inx 1787 5 adverse adverse JJ cord-010092-uftc8inx 1787 6 outcome outcome NN cord-010092-uftc8inx 1787 7 , , , cord-010092-uftc8inx 1787 8 hemoglobin hemoglobin NN cord-010092-uftc8inx 1787 9 deferral deferral NN cord-010092-uftc8inx 1787 10 , , , cord-010092-uftc8inx 1787 11 low low JJ cord-010092-uftc8inx 1787 12 - - HYPH cord-010092-uftc8inx 1787 13 iron iron NN cord-010092-uftc8inx 1787 14 donation donation NN cord-010092-uftc8inx 1787 15 ( ( -LRB- cord-010092-uftc8inx 1787 16 ferritin ferritin NN cord-010092-uftc8inx 1787 17 < < XX cord-010092-uftc8inx 1787 18 20 20 CD cord-010092-uftc8inx 1787 19 ng ng NNP cord-010092-uftc8inx 1787 20 / / SYM cord-010092-uftc8inx 1787 21 ml ml NN cord-010092-uftc8inx 1787 22 for for IN cord-010092-uftc8inx 1787 23 women woman NNS cord-010092-uftc8inx 1787 24 and and CC cord-010092-uftc8inx 1787 25 < < XX cord-010092-uftc8inx 1787 26 30 30 CD cord-010092-uftc8inx 1787 27 ng ng NN cord-010092-uftc8inx 1787 28 / / SYM cord-010092-uftc8inx 1787 29 ml ml NN cord-010092-uftc8inx 1787 30 for for IN cord-010092-uftc8inx 1787 31 men man NNS cord-010092-uftc8inx 1787 32 ) ) -RRB- cord-010092-uftc8inx 1787 33 , , , cord-010092-uftc8inx 1787 34 or or CC cord-010092-uftc8inx 1787 35 absent absent JJ cord-010092-uftc8inx 1787 36 - - HYPH cord-010092-uftc8inx 1787 37 iron iron NN cord-010092-uftc8inx 1787 38 donation donation NN cord-010092-uftc8inx 1787 39 ( ( -LRB- cord-010092-uftc8inx 1787 40 ferritin ferritin NN cord-010092-uftc8inx 1787 41 < < XX cord-010092-uftc8inx 1787 42 12 12 CD cord-010092-uftc8inx 1787 43 ng ng NNP cord-010092-uftc8inx 1787 44 / / SYM cord-010092-uftc8inx 1787 45 ml ml NN cord-010092-uftc8inx 1787 46 for for IN cord-010092-uftc8inx 1787 47 men man NNS cord-010092-uftc8inx 1787 48 and and CC cord-010092-uftc8inx 1787 49 women woman NNS cord-010092-uftc8inx 1787 50 ) ) -RRB- cord-010092-uftc8inx 1787 51 . . . cord-010092-uftc8inx 1788 1 We -PRON- PRP cord-010092-uftc8inx 1788 2 trained train VBD cord-010092-uftc8inx 1788 3 multiple multiple JJ cord-010092-uftc8inx 1788 4 machine machine NN cord-010092-uftc8inx 1788 5 learning learn VBG cord-010092-uftc8inx 1788 6 models model NNS cord-010092-uftc8inx 1788 7 on on IN cord-010092-uftc8inx 1788 8 2,543 2,543 CD cord-010092-uftc8inx 1788 9 of of IN cord-010092-uftc8inx 1788 10 the the DT cord-010092-uftc8inx 1788 11 donations donation NNS cord-010092-uftc8inx 1788 12 and and CC cord-010092-uftc8inx 1788 13 selected select VBD cord-010092-uftc8inx 1788 14 the the DT cord-010092-uftc8inx 1788 15 model model NN cord-010092-uftc8inx 1788 16 with with IN cord-010092-uftc8inx 1788 17 the the DT cord-010092-uftc8inx 1788 18 best good JJS cord-010092-uftc8inx 1788 19 performance performance NN cord-010092-uftc8inx 1788 20 ( ( -LRB- cord-010092-uftc8inx 1788 21 lowest low JJS cord-010092-uftc8inx 1788 22 cross cross JJ cord-010092-uftc8inx 1788 23 - - JJ cord-010092-uftc8inx 1788 24 entropy entropy JJ cord-010092-uftc8inx 1788 25 loss loss NN cord-010092-uftc8inx 1788 26 in in IN cord-010092-uftc8inx 1788 27 cross cross NN cord-010092-uftc8inx 1788 28 validation validation NN cord-010092-uftc8inx 1788 29 ) ) -RRB- cord-010092-uftc8inx 1788 30 . . . cord-010092-uftc8inx 1789 1 We -PRON- PRP cord-010092-uftc8inx 1789 2 assessed assess VBD cord-010092-uftc8inx 1789 3 the the DT cord-010092-uftc8inx 1789 4 best good JJS cord-010092-uftc8inx 1789 5 model model NN cord-010092-uftc8inx 1789 6 's 's POS cord-010092-uftc8inx 1789 7 performance performance NN cord-010092-uftc8inx 1789 8 on on IN cord-010092-uftc8inx 1789 9 a a DT cord-010092-uftc8inx 1789 10 hold hold VB cord-010092-uftc8inx 1789 11 - - HYPH cord-010092-uftc8inx 1789 12 out out NN cord-010092-uftc8inx 1789 13 test test NN cord-010092-uftc8inx 1789 14 set set VBN cord-010092-uftc8inx 1789 15 of of IN cord-010092-uftc8inx 1789 16 620 620 CD cord-010092-uftc8inx 1789 17 donations donation NNS cord-010092-uftc8inx 1789 18 , , , cord-010092-uftc8inx 1789 19 which which WDT cord-010092-uftc8inx 1789 20 were be VBD cord-010092-uftc8inx 1789 21 not not RB cord-010092-uftc8inx 1789 22 used use VBN cord-010092-uftc8inx 1789 23 to to TO cord-010092-uftc8inx 1789 24 train train VB cord-010092-uftc8inx 1789 25 or or CC cord-010092-uftc8inx 1789 26 select select VB cord-010092-uftc8inx 1789 27 the the DT cord-010092-uftc8inx 1789 28 model model NN cord-010092-uftc8inx 1789 29 . . . cord-010092-uftc8inx 1790 1 We -PRON- PRP cord-010092-uftc8inx 1790 2 then then RB cord-010092-uftc8inx 1790 3 used use VBD cord-010092-uftc8inx 1790 4 our -PRON- PRP$ cord-010092-uftc8inx 1790 5 model model NN cord-010092-uftc8inx 1790 6 to to TO cord-010092-uftc8inx 1790 7 generate generate VB cord-010092-uftc8inx 1790 8 risk risk NN cord-010092-uftc8inx 1790 9 estimates estimate NNS cord-010092-uftc8inx 1790 10 for for IN cord-010092-uftc8inx 1790 11 these these DT cord-010092-uftc8inx 1790 12 620 620 CD cord-010092-uftc8inx 1790 13 test test NN cord-010092-uftc8inx 1790 14 donors donor NNS cord-010092-uftc8inx 1790 15 as as IN cord-010092-uftc8inx 1790 16 a a DT cord-010092-uftc8inx 1790 17 function function NN cord-010092-uftc8inx 1790 18 of of IN cord-010092-uftc8inx 1790 19 days day NNS cord-010092-uftc8inx 1790 20 since since IN cord-010092-uftc8inx 1790 21 their -PRON- PRP$ cord-010092-uftc8inx 1790 22 last last JJ cord-010092-uftc8inx 1790 23 donation donation NN cord-010092-uftc8inx 1790 24 , , , cord-010092-uftc8inx 1790 25 which which WDT cord-010092-uftc8inx 1790 26 varied vary VBD cord-010092-uftc8inx 1790 27 from from IN cord-010092-uftc8inx 1790 28 56 56 CD cord-010092-uftc8inx 1790 29 days day NNS cord-010092-uftc8inx 1790 30 to to IN cord-010092-uftc8inx 1790 31 250 250 CD cord-010092-uftc8inx 1790 32 days day NNS cord-010092-uftc8inx 1790 33 . . . cord-010092-uftc8inx 1791 1 To to TO cord-010092-uftc8inx 1791 2 show show VB cord-010092-uftc8inx 1791 3 individual individual JJ cord-010092-uftc8inx 1791 4 variation variation NN cord-010092-uftc8inx 1791 5 , , , cord-010092-uftc8inx 1791 6 we -PRON- PRP cord-010092-uftc8inx 1791 7 generated generate VBD cord-010092-uftc8inx 1791 8 graphical graphical JJ cord-010092-uftc8inx 1791 9 representations representation NNS cord-010092-uftc8inx 1791 10 of of IN cord-010092-uftc8inx 1791 11 individual individual JJ cord-010092-uftc8inx 1791 12 donors donor NNS cord-010092-uftc8inx 1791 13 ' ' POS cord-010092-uftc8inx 1791 14 risk risk NN cord-010092-uftc8inx 1791 15 over over IN cord-010092-uftc8inx 1791 16 time time NN cord-010092-uftc8inx 1791 17 . . . cord-010092-uftc8inx 1792 1 Results result NNS cord-010092-uftc8inx 1792 2 : : : cord-010092-uftc8inx 1793 1 Ferritin ferritin NN cord-010092-uftc8inx 1793 2 , , , cord-010092-uftc8inx 1793 3 log log NN cord-010092-uftc8inx 1793 4 ferritin ferritin NN cord-010092-uftc8inx 1793 5 , , , cord-010092-uftc8inx 1793 6 body body NN cord-010092-uftc8inx 1793 7 iron iron NN cord-010092-uftc8inx 1793 8 , , , cord-010092-uftc8inx 1793 9 and and CC cord-010092-uftc8inx 1793 10 time time NN cord-010092-uftc8inx 1793 11 since since IN cord-010092-uftc8inx 1793 12 last last JJ cord-010092-uftc8inx 1793 13 donation donation NN cord-010092-uftc8inx 1793 14 were be VBD cord-010092-uftc8inx 1793 15 most most RBS cord-010092-uftc8inx 1793 16 useful useful JJ cord-010092-uftc8inx 1793 17 for for IN cord-010092-uftc8inx 1793 18 predicting predict VBG cord-010092-uftc8inx 1793 19 iron iron NN cord-010092-uftc8inx 1793 20 - - HYPH cord-010092-uftc8inx 1793 21 related relate VBN cord-010092-uftc8inx 1793 22 adverse adverse JJ cord-010092-uftc8inx 1793 23 outcomes outcome NNS cord-010092-uftc8inx 1793 24 at at IN cord-010092-uftc8inx 1793 25 the the DT cord-010092-uftc8inx 1793 26 next next JJ cord-010092-uftc8inx 1793 27 donation donation NN cord-010092-uftc8inx 1793 28 attempt attempt NN cord-010092-uftc8inx 1793 29 . . . cord-010092-uftc8inx 1794 1 The the DT cord-010092-uftc8inx 1794 2 estimated estimate VBN cord-010092-uftc8inx 1794 3 risk risk NN cord-010092-uftc8inx 1794 4 of of IN cord-010092-uftc8inx 1794 5 adverse adverse JJ cord-010092-uftc8inx 1794 6 outcomes outcome NNS cord-010092-uftc8inx 1794 7 at at IN cord-010092-uftc8inx 1794 8 the the DT cord-010092-uftc8inx 1794 9 next next JJ cord-010092-uftc8inx 1794 10 donation donation NN cord-010092-uftc8inx 1794 11 attempt attempt NN cord-010092-uftc8inx 1794 12 varied varied JJ cord-010092-uftc8inx 1794 13 considerably considerably RB cord-010092-uftc8inx 1794 14 across across IN cord-010092-uftc8inx 1794 15 donors donor NNS cord-010092-uftc8inx 1794 16 . . . cord-010092-uftc8inx 1795 1 As as IN cord-010092-uftc8inx 1795 2 expected expect VBN cord-010092-uftc8inx 1795 3 , , , cord-010092-uftc8inx 1795 4 the the DT cord-010092-uftc8inx 1795 5 risk risk NN cord-010092-uftc8inx 1795 6 of of IN cord-010092-uftc8inx 1795 7 adverse adverse JJ cord-010092-uftc8inx 1795 8 outcomes outcome NNS cord-010092-uftc8inx 1795 9 250 250 CD cord-010092-uftc8inx 1795 10 days day NNS cord-010092-uftc8inx 1795 11 after after IN cord-010092-uftc8inx 1795 12 the the DT cord-010092-uftc8inx 1795 13 last last JJ cord-010092-uftc8inx 1795 14 donation donation NN cord-010092-uftc8inx 1795 15 was be VBD cord-010092-uftc8inx 1795 16 lower low JJR cord-010092-uftc8inx 1795 17 than than IN cord-010092-uftc8inx 1795 18 the the DT cord-010092-uftc8inx 1795 19 risk risk NN cord-010092-uftc8inx 1795 20 56 56 CD cord-010092-uftc8inx 1795 21 days day NNS cord-010092-uftc8inx 1795 22 after after IN cord-010092-uftc8inx 1795 23 the the DT cord-010092-uftc8inx 1795 24 last last JJ cord-010092-uftc8inx 1795 25 donation donation NN cord-010092-uftc8inx 1795 26 for for IN cord-010092-uftc8inx 1795 27 most most JJS cord-010092-uftc8inx 1795 28 donors donor NNS cord-010092-uftc8inx 1795 29 ( ( -LRB- cord-010092-uftc8inx 1795 30 risk risk NN cord-010092-uftc8inx 1795 31 of of IN cord-010092-uftc8inx 1795 32 hemoglobin hemoglobin NN cord-010092-uftc8inx 1795 33 deferral deferral NN cord-010092-uftc8inx 1795 34 decreased decrease VBD cord-010092-uftc8inx 1795 35 for for IN cord-010092-uftc8inx 1795 36 84 84 CD cord-010092-uftc8inx 1795 37 % % NN cord-010092-uftc8inx 1795 38 of of IN cord-010092-uftc8inx 1795 39 donors donor NNS cord-010092-uftc8inx 1795 40 ; ; : cord-010092-uftc8inx 1795 41 risk risk NN cord-010092-uftc8inx 1795 42 for for IN cord-010092-uftc8inx 1795 43 low low JJ cord-010092-uftc8inx 1795 44 - - HYPH cord-010092-uftc8inx 1795 45 iron iron NN cord-010092-uftc8inx 1795 46 donation donation NN cord-010092-uftc8inx 1795 47 decreased decrease VBD cord-010092-uftc8inx 1795 48 for for IN cord-010092-uftc8inx 1795 49 61 61 CD cord-010092-uftc8inx 1795 50 % % NN cord-010092-uftc8inx 1795 51 ; ; , cord-010092-uftc8inx 1795 52 and and CC cord-010092-uftc8inx 1795 53 risk risk NN cord-010092-uftc8inx 1795 54 for for IN cord-010092-uftc8inx 1795 55 absent absent JJ cord-010092-uftc8inx 1795 56 - - HYPH cord-010092-uftc8inx 1795 57 iron iron NN cord-010092-uftc8inx 1795 58 donation donation NN cord-010092-uftc8inx 1795 59 decreased decrease VBD cord-010092-uftc8inx 1795 60 for for IN cord-010092-uftc8inx 1795 61 94 94 CD cord-010092-uftc8inx 1795 62 % % NN cord-010092-uftc8inx 1795 63 ) ) -RRB- cord-010092-uftc8inx 1795 64 . . . cord-010092-uftc8inx 1796 1 Summary Summary NNP cord-010092-uftc8inx 1796 2 / / SYM cord-010092-uftc8inx 1796 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 1796 4 : : : cord-010092-uftc8inx 1797 1 The the DT cord-010092-uftc8inx 1797 2 risk risk NN cord-010092-uftc8inx 1797 3 of of IN cord-010092-uftc8inx 1797 4 iron iron NN cord-010092-uftc8inx 1797 5 - - HYPH cord-010092-uftc8inx 1797 6 related relate VBN cord-010092-uftc8inx 1797 7 adverse adverse JJ cord-010092-uftc8inx 1797 8 outcomes outcome NNS cord-010092-uftc8inx 1797 9 as as IN cord-010092-uftc8inx 1797 10 a a DT cord-010092-uftc8inx 1797 11 function function NN cord-010092-uftc8inx 1797 12 of of IN cord-010092-uftc8inx 1797 13 time time NN cord-010092-uftc8inx 1797 14 since since IN cord-010092-uftc8inx 1797 15 last last JJ cord-010092-uftc8inx 1797 16 donation donation NN cord-010092-uftc8inx 1797 17 varies vary VBZ cord-010092-uftc8inx 1797 18 considerably considerably RB cord-010092-uftc8inx 1797 19 between between IN cord-010092-uftc8inx 1797 20 donors donor NNS cord-010092-uftc8inx 1797 21 . . . cord-010092-uftc8inx 1798 1 Machine machine NN cord-010092-uftc8inx 1798 2 learning learning NN cord-010092-uftc8inx 1798 3 models model NNS cord-010092-uftc8inx 1798 4 trained train VBN cord-010092-uftc8inx 1798 5 on on IN cord-010092-uftc8inx 1798 6 relevant relevant JJ cord-010092-uftc8inx 1798 7 donor donor NN cord-010092-uftc8inx 1798 8 profiles profile NNS cord-010092-uftc8inx 1798 9 can can MD cord-010092-uftc8inx 1798 10 effectively effectively RB cord-010092-uftc8inx 1798 11 estimate estimate VB cord-010092-uftc8inx 1798 12 how how WRB cord-010092-uftc8inx 1798 13 an an DT cord-010092-uftc8inx 1798 14 individual individual NN cord-010092-uftc8inx 1798 15 's 's POS cord-010092-uftc8inx 1798 16 risk risk NN cord-010092-uftc8inx 1798 17 will will MD cord-010092-uftc8inx 1798 18 change change VB cord-010092-uftc8inx 1798 19 over over IN cord-010092-uftc8inx 1798 20 time time NN cord-010092-uftc8inx 1798 21 . . . cord-010092-uftc8inx 1799 1 Individual individual JJ cord-010092-uftc8inx 1799 2 risk risk NN cord-010092-uftc8inx 1799 3 estimates estimate NNS cord-010092-uftc8inx 1799 4 could could MD cord-010092-uftc8inx 1799 5 allow allow VB cord-010092-uftc8inx 1799 6 blood blood NN cord-010092-uftc8inx 1799 7 centers center NNS cord-010092-uftc8inx 1799 8 to to TO cord-010092-uftc8inx 1799 9 protect protect VB cord-010092-uftc8inx 1799 10 highrisk highrisk JJ cord-010092-uftc8inx 1799 11 repeat repeat NN cord-010092-uftc8inx 1799 12 donors donor NNS cord-010092-uftc8inx 1799 13 while while IN cord-010092-uftc8inx 1799 14 continuing continue VBG cord-010092-uftc8inx 1799 15 to to TO cord-010092-uftc8inx 1799 16 allow allow VB cord-010092-uftc8inx 1799 17 more more RBR cord-010092-uftc8inx 1799 18 frequent frequent JJ cord-010092-uftc8inx 1799 19 collections collection NNS cord-010092-uftc8inx 1799 20 from from IN cord-010092-uftc8inx 1799 21 low low JJ cord-010092-uftc8inx 1799 22 - - HYPH cord-010092-uftc8inx 1799 23 risk risk NN cord-010092-uftc8inx 1799 24 donors donor NNS cord-010092-uftc8inx 1799 25 . . . cord-010092-uftc8inx 1800 1 Further further JJ cord-010092-uftc8inx 1800 2 study study NN cord-010092-uftc8inx 1800 3 is be VBZ cord-010092-uftc8inx 1800 4 needed need VBN cord-010092-uftc8inx 1800 5 to to TO cord-010092-uftc8inx 1800 6 ensure ensure VB cord-010092-uftc8inx 1800 7 this this DT cord-010092-uftc8inx 1800 8 approach approach NN cord-010092-uftc8inx 1800 9 works work VBZ cord-010092-uftc8inx 1800 10 well well RB cord-010092-uftc8inx 1800 11 for for IN cord-010092-uftc8inx 1800 12 donor donor NN cord-010092-uftc8inx 1800 13 classes class NNS cord-010092-uftc8inx 1800 14 that that WDT cord-010092-uftc8inx 1800 15 are be VBP cord-010092-uftc8inx 1800 16 not not RB cord-010092-uftc8inx 1800 17 well well RB cord-010092-uftc8inx 1800 18 - - HYPH cord-010092-uftc8inx 1800 19 represented represent VBN cord-010092-uftc8inx 1800 20 by by IN cord-010092-uftc8inx 1800 21 the the DT cord-010092-uftc8inx 1800 22 RISE RISE NNP cord-010092-uftc8inx 1800 23 dataset dataset NN cord-010092-uftc8inx 1800 24 , , , cord-010092-uftc8inx 1800 25 to to TO cord-010092-uftc8inx 1800 26 assess assess VB cord-010092-uftc8inx 1800 27 risk risk NN cord-010092-uftc8inx 1800 28 prediction prediction NN cord-010092-uftc8inx 1800 29 outside outside IN cord-010092-uftc8inx 1800 30 of of IN cord-010092-uftc8inx 1800 31 the the DT cord-010092-uftc8inx 1800 32 physiological physiological JJ cord-010092-uftc8inx 1800 33 measures measure NNS cord-010092-uftc8inx 1800 34 collected collect VBN cord-010092-uftc8inx 1800 35 in in IN cord-010092-uftc8inx 1800 36 the the DT cord-010092-uftc8inx 1800 37 RISE rise JJ cord-010092-uftc8inx 1800 38 study study NN cord-010092-uftc8inx 1800 39 , , , cord-010092-uftc8inx 1800 40 and and CC cord-010092-uftc8inx 1800 41 to to TO cord-010092-uftc8inx 1800 42 determine determine VB cord-010092-uftc8inx 1800 43 the the DT cord-010092-uftc8inx 1800 44 viability viability NN cord-010092-uftc8inx 1800 45 of of IN cord-010092-uftc8inx 1800 46 assigning assign VBG cord-010092-uftc8inx 1800 47 an an DT cord-010092-uftc8inx 1800 48 optimal optimal JJ cord-010092-uftc8inx 1800 49 inter inter JJ cord-010092-uftc8inx 1800 50 - - JJ cord-010092-uftc8inx 1800 51 donation donation NN cord-010092-uftc8inx 1800 52 interval interval NN cord-010092-uftc8inx 1800 53 to to IN cord-010092-uftc8inx 1800 54 a a DT cord-010092-uftc8inx 1800 55 first first JJ cord-010092-uftc8inx 1800 56 - - HYPH cord-010092-uftc8inx 1800 57 time time NN cord-010092-uftc8inx 1800 58 donor donor NN cord-010092-uftc8inx 1800 59 using use VBG cord-010092-uftc8inx 1800 60 this this DT cord-010092-uftc8inx 1800 61 approach approach NN cord-010092-uftc8inx 1800 62 . . . cord-010092-uftc8inx 1801 1 Background background NN cord-010092-uftc8inx 1801 2 : : : cord-010092-uftc8inx 1802 1 Iron iron NN cord-010092-uftc8inx 1802 2 depletion depletion NN cord-010092-uftc8inx 1802 3 is be VBZ cord-010092-uftc8inx 1802 4 common common JJ cord-010092-uftc8inx 1802 5 among among IN cord-010092-uftc8inx 1802 6 repeat repeat NN cord-010092-uftc8inx 1802 7 blood blood NN cord-010092-uftc8inx 1802 8 donors donor NNS cord-010092-uftc8inx 1802 9 , , , cord-010092-uftc8inx 1802 10 who who WP cord-010092-uftc8inx 1802 11 contribute contribute VBP cord-010092-uftc8inx 1802 12 a a DT cord-010092-uftc8inx 1802 13 large large JJ cord-010092-uftc8inx 1802 14 proportion proportion NN cord-010092-uftc8inx 1802 15 of of IN cord-010092-uftc8inx 1802 16 the the DT cord-010092-uftc8inx 1802 17 blood blood NN cord-010092-uftc8inx 1802 18 supply supply NN cord-010092-uftc8inx 1802 19 in in IN cord-010092-uftc8inx 1802 20 many many JJ cord-010092-uftc8inx 1802 21 countries country NNS cord-010092-uftc8inx 1802 22 . . . cord-010092-uftc8inx 1803 1 Exogenous exogenous JJ cord-010092-uftc8inx 1803 2 iron iron NN cord-010092-uftc8inx 1803 3 from from IN cord-010092-uftc8inx 1803 4 multivitamins multivitamin NNS cord-010092-uftc8inx 1803 5 with with IN cord-010092-uftc8inx 1803 6 iron iron NN cord-010092-uftc8inx 1803 7 or or CC cord-010092-uftc8inx 1803 8 iron iron NN cord-010092-uftc8inx 1803 9 - - HYPH cord-010092-uftc8inx 1803 10 only only RB cord-010092-uftc8inx 1803 11 supplements supplement NNS cord-010092-uftc8inx 1803 12 helps help VBZ cord-010092-uftc8inx 1803 13 prevent prevent VB cord-010092-uftc8inx 1803 14 donation donation NN cord-010092-uftc8inx 1803 15 - - HYPH cord-010092-uftc8inx 1803 16 induced induce VBN cord-010092-uftc8inx 1803 17 iron iron NN cord-010092-uftc8inx 1803 18 depletion depletion NN cord-010092-uftc8inx 1803 19 , , , cord-010092-uftc8inx 1803 20 but but CC cord-010092-uftc8inx 1803 21 whether whether IN cord-010092-uftc8inx 1803 22 dietary dietary JJ cord-010092-uftc8inx 1803 23 iron iron NN cord-010092-uftc8inx 1803 24 protects protect VBZ cord-010092-uftc8inx 1803 25 against against IN cord-010092-uftc8inx 1803 26 iron iron NN cord-010092-uftc8inx 1803 27 depletion depletion NN cord-010092-uftc8inx 1803 28 in in IN cord-010092-uftc8inx 1803 29 repeat repeat NN cord-010092-uftc8inx 1803 30 donors donor NNS cord-010092-uftc8inx 1803 31 has have VBZ cord-010092-uftc8inx 1803 32 not not RB cord-010092-uftc8inx 1803 33 been be VBN cord-010092-uftc8inx 1803 34 rigorously rigorously RB cord-010092-uftc8inx 1803 35 evaluated evaluate VBN cord-010092-uftc8inx 1803 36 . . . cord-010092-uftc8inx 1804 1 Available available JJ cord-010092-uftc8inx 1804 2 data datum NNS cord-010092-uftc8inx 1804 3 from from IN cord-010092-uftc8inx 1804 4 the the DT cord-010092-uftc8inx 1804 5 REDS REDS NNPS cord-010092-uftc8inx 1804 6 - - HYPH cord-010092-uftc8inx 1804 7 II II NNP cord-010092-uftc8inx 1804 8 RISE rise JJ cord-010092-uftc8inx 1804 9 study study NN cord-010092-uftc8inx 1804 10 in in IN cord-010092-uftc8inx 1804 11 the the DT cord-010092-uftc8inx 1804 12 US US NNP cord-010092-uftc8inx 1804 13 ( ( -LRB- cord-010092-uftc8inx 1804 14 Cable Cable NNP cord-010092-uftc8inx 1804 15 , , , cord-010092-uftc8inx 1804 16 Transfusion Transfusion NNP cord-010092-uftc8inx 1804 17 , , , cord-010092-uftc8inx 1804 18 2011 2011 CD cord-010092-uftc8inx 1804 19 ) ) -RRB- cord-010092-uftc8inx 1804 20 and and CC cord-010092-uftc8inx 1804 21 from from IN cord-010092-uftc8inx 1804 22 the the DT cord-010092-uftc8inx 1804 23 Danish Danish NNP cord-010092-uftc8inx 1804 24 Blood Blood NNP cord-010092-uftc8inx 1804 25 Donor Donor NNP cord-010092-uftc8inx 1804 26 Study Study NNP cord-010092-uftc8inx 1804 27 ( ( -LRB- cord-010092-uftc8inx 1804 28 Rigas Rigas NNP cord-010092-uftc8inx 1804 29 , , , cord-010092-uftc8inx 1804 30 Transfusion Transfusion NNP cord-010092-uftc8inx 1804 31 , , , cord-010092-uftc8inx 1804 32 2014 2014 CD cord-010092-uftc8inx 1804 33 ) ) -RRB- cord-010092-uftc8inx 1804 34 suggest suggest VB cord-010092-uftc8inx 1804 35 minor minor JJ cord-010092-uftc8inx 1804 36 impact impact NN cord-010092-uftc8inx 1804 37 of of IN cord-010092-uftc8inx 1804 38 dietary dietary JJ cord-010092-uftc8inx 1804 39 iron iron NN cord-010092-uftc8inx 1804 40 consumption consumption NN cord-010092-uftc8inx 1804 41 on on IN cord-010092-uftc8inx 1804 42 blood blood NN cord-010092-uftc8inx 1804 43 donor donor NN cord-010092-uftc8inx 1804 44 iron iron NN cord-010092-uftc8inx 1804 45 status status NN cord-010092-uftc8inx 1804 46 in in IN cord-010092-uftc8inx 1804 47 multivariable multivariable JJ cord-010092-uftc8inx 1804 48 regression regression NN cord-010092-uftc8inx 1804 49 models model NNS cord-010092-uftc8inx 1804 50 . . . cord-010092-uftc8inx 1805 1 Both both DT cord-010092-uftc8inx 1805 2 studies study NNS cord-010092-uftc8inx 1805 3 , , , cord-010092-uftc8inx 1805 4 however however RB cord-010092-uftc8inx 1805 5 , , , cord-010092-uftc8inx 1805 6 analyzed analyze VBD cord-010092-uftc8inx 1805 7 food food NN cord-010092-uftc8inx 1805 8 items item NNS cord-010092-uftc8inx 1805 9 singly singly RB cord-010092-uftc8inx 1805 10 , , , cord-010092-uftc8inx 1805 11 such such JJ cord-010092-uftc8inx 1805 12 as as IN cord-010092-uftc8inx 1805 13 beef beef NN cord-010092-uftc8inx 1805 14 or or CC cord-010092-uftc8inx 1805 15 fish fish NN cord-010092-uftc8inx 1805 16 , , , cord-010092-uftc8inx 1805 17 rather rather RB cord-010092-uftc8inx 1805 18 than than IN cord-010092-uftc8inx 1805 19 in in IN cord-010092-uftc8inx 1805 20 aggregate aggregate NN cord-010092-uftc8inx 1805 21 , , , cord-010092-uftc8inx 1805 22 so so RB cord-010092-uftc8inx 1805 23 precision precision NN cord-010092-uftc8inx 1805 24 was be VBD cord-010092-uftc8inx 1805 25 limited limit VBN cord-010092-uftc8inx 1805 26 . . . cord-010092-uftc8inx 1806 1 Aims aim VBZ cord-010092-uftc8inx 1806 2 : : : cord-010092-uftc8inx 1807 1 To to TO cord-010092-uftc8inx 1807 2 evaluate evaluate VB cord-010092-uftc8inx 1807 3 whether whether IN cord-010092-uftc8inx 1807 4 a a DT cord-010092-uftc8inx 1807 5 composite composite JJ cord-010092-uftc8inx 1807 6 measure measure NN cord-010092-uftc8inx 1807 7 of of IN cord-010092-uftc8inx 1807 8 dietary dietary JJ cord-010092-uftc8inx 1807 9 heme heme NN cord-010092-uftc8inx 1807 10 iron iron NN cord-010092-uftc8inx 1807 11 consumption consumption NN cord-010092-uftc8inx 1807 12 , , , cord-010092-uftc8inx 1807 13 weighted weight VBN cord-010092-uftc8inx 1807 14 for for IN cord-010092-uftc8inx 1807 15 frequency frequency NN cord-010092-uftc8inx 1807 16 and and CC cord-010092-uftc8inx 1807 17 iron iron NN cord-010092-uftc8inx 1807 18 content content NN cord-010092-uftc8inx 1807 19 , , , cord-010092-uftc8inx 1807 20 was be VBD cord-010092-uftc8inx 1807 21 associated associate VBN cord-010092-uftc8inx 1807 22 with with IN cord-010092-uftc8inx 1807 23 incident incident NN cord-010092-uftc8inx 1807 24 iron iron NN cord-010092-uftc8inx 1807 25 depletion depletion NN cord-010092-uftc8inx 1807 26 among among IN cord-010092-uftc8inx 1807 27 repeat repeat NN cord-010092-uftc8inx 1807 28 blood blood NN cord-010092-uftc8inx 1807 29 donors donor NNS cord-010092-uftc8inx 1807 30 . . . cord-010092-uftc8inx 1808 1 Methods method NNS cord-010092-uftc8inx 1808 2 : : : cord-010092-uftc8inx 1809 1 A a DT cord-010092-uftc8inx 1809 2 re re NN cord-010092-uftc8inx 1809 3 - - NN cord-010092-uftc8inx 1809 4 analysis analysis NN cord-010092-uftc8inx 1809 5 of of IN cord-010092-uftc8inx 1809 6 the the DT cord-010092-uftc8inx 1809 7 RISE RISE NNP cord-010092-uftc8inx 1809 8 cohort cohort NN cord-010092-uftc8inx 1809 9 was be VBD cord-010092-uftc8inx 1809 10 undertaken undertake VBN cord-010092-uftc8inx 1809 11 to to TO cord-010092-uftc8inx 1809 12 test test VB cord-010092-uftc8inx 1809 13 the the DT cord-010092-uftc8inx 1809 14 hypothesis hypothesis NN cord-010092-uftc8inx 1809 15 that that WDT cord-010092-uftc8inx 1809 16 reported report VBD cord-010092-uftc8inx 1809 17 levels level NNS cord-010092-uftc8inx 1809 18 of of IN cord-010092-uftc8inx 1809 19 animal animal NN cord-010092-uftc8inx 1809 20 protein protein NN cord-010092-uftc8inx 1809 21 consumption consumption NN cord-010092-uftc8inx 1809 22 was be VBD cord-010092-uftc8inx 1809 23 associated associate VBN cord-010092-uftc8inx 1809 24 with with IN cord-010092-uftc8inx 1809 25 lower low JJR cord-010092-uftc8inx 1809 26 risk risk NN cord-010092-uftc8inx 1809 27 for for IN cord-010092-uftc8inx 1809 28 incident incident NN cord-010092-uftc8inx 1809 29 iron iron NN cord-010092-uftc8inx 1809 30 depletion depletion NN cord-010092-uftc8inx 1809 31 among among IN cord-010092-uftc8inx 1809 32 repeat repeat NN cord-010092-uftc8inx 1809 33 blood blood NN cord-010092-uftc8inx 1809 34 donors donor NNS cord-010092-uftc8inx 1809 35 . . . cord-010092-uftc8inx 1810 1 The the DT cord-010092-uftc8inx 1810 2 six six CD cord-010092-uftc8inx 1810 3 blood blood NN cord-010092-uftc8inx 1810 4 centers center NNS cord-010092-uftc8inx 1810 5 participating participate VBG cord-010092-uftc8inx 1810 6 in in IN cord-010092-uftc8inx 1810 7 RISE RISE NNP cord-010092-uftc8inx 1810 8 enrolled enrol VBD cord-010092-uftc8inx 1810 9 first first JJ cord-010092-uftc8inx 1810 10 - - HYPH cord-010092-uftc8inx 1810 11 time time NN cord-010092-uftc8inx 1810 12 and and CC cord-010092-uftc8inx 1810 13 frequent frequent JJ cord-010092-uftc8inx 1810 14 donors donor NNS cord-010092-uftc8inx 1810 15 for for IN cord-010092-uftc8inx 1810 16 15 15 CD cord-010092-uftc8inx 1810 17 - - SYM cord-010092-uftc8inx 1810 18 24 24 CD cord-010092-uftc8inx 1810 19 month month NN cord-010092-uftc8inx 1810 20 follow follow NN cord-010092-uftc8inx 1810 21 - - HYPH cord-010092-uftc8inx 1810 22 up up NN cord-010092-uftc8inx 1810 23 of of IN cord-010092-uftc8inx 1810 24 donation donation NN cord-010092-uftc8inx 1810 25 frequency frequency NN cord-010092-uftc8inx 1810 26 and and CC cord-010092-uftc8inx 1810 27 iron iron NN cord-010092-uftc8inx 1810 28 status status NN cord-010092-uftc8inx 1810 29 . . . cord-010092-uftc8inx 1811 1 A a DT cord-010092-uftc8inx 1811 2 brief brief JJ cord-010092-uftc8inx 1811 3 checklist checklist NN cord-010092-uftc8inx 1811 4 of of IN cord-010092-uftc8inx 1811 5 8 8 CD cord-010092-uftc8inx 1811 6 food food NN cord-010092-uftc8inx 1811 7 categories category NNS cord-010092-uftc8inx 1811 8 was be VBD cord-010092-uftc8inx 1811 9 administered administer VBN cord-010092-uftc8inx 1811 10 at at IN cord-010092-uftc8inx 1811 11 baseline baseline NN cord-010092-uftc8inx 1811 12 to to TO cord-010092-uftc8inx 1811 13 assess assess VB cord-010092-uftc8inx 1811 14 frequency frequency NN cord-010092-uftc8inx 1811 15 of of IN cord-010092-uftc8inx 1811 16 consumption consumption NN cord-010092-uftc8inx 1811 17 of of IN cord-010092-uftc8inx 1811 18 several several JJ cord-010092-uftc8inx 1811 19 categories category NNS cord-010092-uftc8inx 1811 20 of of IN cord-010092-uftc8inx 1811 21 animal animal NN cord-010092-uftc8inx 1811 22 protein protein NN cord-010092-uftc8inx 1811 23 that that WDT cord-010092-uftc8inx 1811 24 are be VBP cord-010092-uftc8inx 1811 25 rich rich JJ cord-010092-uftc8inx 1811 26 in in IN cord-010092-uftc8inx 1811 27 heme heme NN cord-010092-uftc8inx 1811 28 iron iron NN cord-010092-uftc8inx 1811 29 , , , cord-010092-uftc8inx 1811 30 the the DT cord-010092-uftc8inx 1811 31 biochemical biochemical JJ cord-010092-uftc8inx 1811 32 form form NN cord-010092-uftc8inx 1811 33 of of IN cord-010092-uftc8inx 1811 34 iron iron NN cord-010092-uftc8inx 1811 35 most most RBS cord-010092-uftc8inx 1811 36 readily readily RB cord-010092-uftc8inx 1811 37 absorbed absorb VBN cord-010092-uftc8inx 1811 38 . . . cord-010092-uftc8inx 1812 1 An an DT cord-010092-uftc8inx 1812 2 Iron Iron NNP cord-010092-uftc8inx 1812 3 Composite Composite NNP cord-010092-uftc8inx 1812 4 Score Score NNP cord-010092-uftc8inx 1812 5 ( ( -LRB- cord-010092-uftc8inx 1812 6 ICS ICS NNP cord-010092-uftc8inx 1812 7 ) ) -RRB- cord-010092-uftc8inx 1812 8 weighted weight VBN cord-010092-uftc8inx 1812 9 for for IN cord-010092-uftc8inx 1812 10 frequency frequency NN cord-010092-uftc8inx 1812 11 and and CC cord-010092-uftc8inx 1812 12 heme heme NN cord-010092-uftc8inx 1812 13 iron iron NN cord-010092-uftc8inx 1812 14 content content NN cord-010092-uftc8inx 1812 15 was be VBD cord-010092-uftc8inx 1812 16 derived derive VBN cord-010092-uftc8inx 1812 17 and and CC cord-010092-uftc8inx 1812 18 subjects subject NNS cord-010092-uftc8inx 1812 19 were be VBD cord-010092-uftc8inx 1812 20 grouped group VBN cord-010092-uftc8inx 1812 21 into into IN cord-010092-uftc8inx 1812 22 tertiles tertile NNS cord-010092-uftc8inx 1812 23 ( ( -LRB- cord-010092-uftc8inx 1812 24 thirds third NNS cord-010092-uftc8inx 1812 25 ) ) -RRB- cord-010092-uftc8inx 1812 26 of of IN cord-010092-uftc8inx 1812 27 ICS ICS NNP cord-010092-uftc8inx 1812 28 . . . cord-010092-uftc8inx 1813 1 Iron iron NN cord-010092-uftc8inx 1813 2 status status NN cord-010092-uftc8inx 1813 3 was be VBD cord-010092-uftc8inx 1813 4 assayed assay VBN cord-010092-uftc8inx 1813 5 at at IN cord-010092-uftc8inx 1813 6 enrollment enrollment NN cord-010092-uftc8inx 1813 7 and and CC cord-010092-uftc8inx 1813 8 study study VB cord-010092-uftc8inx 1813 9 completion completion NN cord-010092-uftc8inx 1813 10 and and CC cord-010092-uftc8inx 1813 11 at at IN cord-010092-uftc8inx 1813 12 roughly roughly RB cord-010092-uftc8inx 1813 13 one one CD cord-010092-uftc8inx 1813 14 - - HYPH cord-010092-uftc8inx 1813 15 third third NN cord-010092-uftc8inx 1813 16 of of IN cord-010092-uftc8inx 1813 17 donation donation NN cord-010092-uftc8inx 1813 18 visits visit NNS cord-010092-uftc8inx 1813 19 in in IN cord-010092-uftc8inx 1813 20 between between IN cord-010092-uftc8inx 1813 21 . . . cord-010092-uftc8inx 1814 1 Modified modify VBN cord-010092-uftc8inx 1814 2 Poisson Poisson NNP cord-010092-uftc8inx 1814 3 regression regression NN cord-010092-uftc8inx 1814 4 with with IN cord-010092-uftc8inx 1814 5 Generalized Generalized NNP cord-010092-uftc8inx 1814 6 Estimating Estimating NNP cord-010092-uftc8inx 1814 7 Equations Equations NNPS cord-010092-uftc8inx 1814 8 was be VBD cord-010092-uftc8inx 1814 9 used use VBN cord-010092-uftc8inx 1814 10 to to TO cord-010092-uftc8inx 1814 11 generate generate VB cord-010092-uftc8inx 1814 12 risk risk NN cord-010092-uftc8inx 1814 13 ratios ratio NNS cord-010092-uftc8inx 1814 14 controlling control VBG cord-010092-uftc8inx 1814 15 for for IN cord-010092-uftc8inx 1814 16 donation donation NN cord-010092-uftc8inx 1814 17 frequency frequency NN cord-010092-uftc8inx 1814 18 and and CC cord-010092-uftc8inx 1814 19 other other JJ cord-010092-uftc8inx 1814 20 covariates covariate NNS cord-010092-uftc8inx 1814 21 . . . cord-010092-uftc8inx 1815 1 Results result NNS cord-010092-uftc8inx 1815 2 : : : cord-010092-uftc8inx 1816 1 Of of IN cord-010092-uftc8inx 1816 2 2425 2425 CD cord-010092-uftc8inx 1816 3 enrolled enrol VBN cord-010092-uftc8inx 1816 4 donors donor NNS cord-010092-uftc8inx 1816 5 , , , cord-010092-uftc8inx 1816 6 1406 1406 CD cord-010092-uftc8inx 1816 7 were be VBD cord-010092-uftc8inx 1816 8 iron iron NN cord-010092-uftc8inx 1816 9 replete replete JJ cord-010092-uftc8inx 1816 10 at at IN cord-010092-uftc8inx 1816 11 baseline baseline NN cord-010092-uftc8inx 1816 12 and and CC cord-010092-uftc8inx 1816 13 completed complete VBD cord-010092-uftc8inx 1816 14 the the DT cord-010092-uftc8inx 1816 15 food food NN cord-010092-uftc8inx 1816 16 checklist checklist NN cord-010092-uftc8inx 1816 17 . . . cord-010092-uftc8inx 1817 1 The the DT cord-010092-uftc8inx 1817 2 median median JJ cord-010092-uftc8inx 1817 3 value value NN cord-010092-uftc8inx 1817 4 of of IN cord-010092-uftc8inx 1817 5 the the DT cord-010092-uftc8inx 1817 6 ICS ICS NNP cord-010092-uftc8inx 1817 7 for for IN cord-010092-uftc8inx 1817 8 each each DT cord-010092-uftc8inx 1817 9 tertile tertile NNP cord-010092-uftc8inx 1817 10 ( ( -LRB- cord-010092-uftc8inx 1817 11 lowest low JJS cord-010092-uftc8inx 1817 12 to to IN cord-010092-uftc8inx 1817 13 highest high JJS cord-010092-uftc8inx 1817 14 ) ) -RRB- cord-010092-uftc8inx 1817 15 was be VBD cord-010092-uftc8inx 1817 16 7 7 CD cord-010092-uftc8inx 1817 17 . . . cord-010092-uftc8inx 1818 1 2 2 CD cord-010092-uftc8inx 1818 2 , , , cord-010092-uftc8inx 1818 3 13.1 13.1 CD cord-010092-uftc8inx 1818 4 , , , cord-010092-uftc8inx 1818 5 and and CC cord-010092-uftc8inx 1818 6 22 22 CD cord-010092-uftc8inx 1818 7 .0 .0 . cord-010092-uftc8inx 1819 1 mg mg NNP cord-010092-uftc8inx 1819 2 of of IN cord-010092-uftc8inx 1819 3 heme heme NNP cord-010092-uftc8inx 1819 4 iron iron NNP cord-010092-uftc8inx 1819 5 weekly weekly RB cord-010092-uftc8inx 1819 6 . . . cord-010092-uftc8inx 1820 1 These these DT cord-010092-uftc8inx 1820 2 values value NNS cord-010092-uftc8inx 1820 3 are be VBP cord-010092-uftc8inx 1820 4 equivalent equivalent JJ cord-010092-uftc8inx 1820 5 to to IN cord-010092-uftc8inx 1820 6 approximately approximately RB cord-010092-uftc8inx 1820 7 3 3 CD cord-010092-uftc8inx 1820 8 , , , cord-010092-uftc8inx 1820 9 6 6 CD cord-010092-uftc8inx 1820 10 , , , cord-010092-uftc8inx 1820 11 and and CC cord-010092-uftc8inx 1820 12 9 9 CD cord-010092-uftc8inx 1820 13 servings serving NNS cord-010092-uftc8inx 1820 14 of of IN cord-010092-uftc8inx 1820 15 beef beef NN cord-010092-uftc8inx 1820 16 per per IN cord-010092-uftc8inx 1820 17 week week NN cord-010092-uftc8inx 1820 18 , , , cord-010092-uftc8inx 1820 19 or or CC cord-010092-uftc8inx 1820 20 alternately alternately RB cord-010092-uftc8inx 1820 21 twice twice PDT cord-010092-uftc8inx 1820 22 as as RB cord-010092-uftc8inx 1820 23 many many JJ cord-010092-uftc8inx 1820 24 servings serving NNS cord-010092-uftc8inx 1820 25 of of IN cord-010092-uftc8inx 1820 26 chicken chicken NN cord-010092-uftc8inx 1820 27 or or CC cord-010092-uftc8inx 1820 28 pork pork NN cord-010092-uftc8inx 1820 29 . . . cord-010092-uftc8inx 1821 1 Across across IN cord-010092-uftc8inx 1821 2 2236 2236 CD cord-010092-uftc8inx 1821 3 follow follow VB cord-010092-uftc8inx 1821 4 - - HYPH cord-010092-uftc8inx 1821 5 up up NN cord-010092-uftc8inx 1821 6 visits visit NNS cord-010092-uftc8inx 1821 7 with with IN cord-010092-uftc8inx 1821 8 iron iron NN cord-010092-uftc8inx 1821 9 outcomes outcome NNS cord-010092-uftc8inx 1821 10 assayed assay VBN cord-010092-uftc8inx 1821 11 , , , cord-010092-uftc8inx 1821 12 almost almost RB cord-010092-uftc8inx 1821 13 33 33 CD cord-010092-uftc8inx 1821 14 % % NN cord-010092-uftc8inx 1821 15 of of IN cord-010092-uftc8inx 1821 16 donor donor NN cord-010092-uftc8inx 1821 17 visits visit NNS cord-010092-uftc8inx 1821 18 were be VBD cord-010092-uftc8inx 1821 19 associated associate VBN cord-010092-uftc8inx 1821 20 with with IN cord-010092-uftc8inx 1821 21 intermediate intermediate JJ cord-010092-uftc8inx 1821 22 iron iron NN cord-010092-uftc8inx 1821 23 depletion depletion NN cord-010092-uftc8inx 1821 24 ( ( -LRB- cord-010092-uftc8inx 1821 25 serum serum NN cord-010092-uftc8inx 1821 26 ferritin ferritin NN cord-010092-uftc8inx 1821 27 < < XX cord-010092-uftc8inx 1821 28 26 26 CD cord-010092-uftc8inx 1821 29 ng ng NNP cord-010092-uftc8inx 1821 30 / / SYM cord-010092-uftc8inx 1821 31 ml ml NN cord-010092-uftc8inx 1821 32 ) ) -RRB- cord-010092-uftc8inx 1821 33 and and CC cord-010092-uftc8inx 1821 34 8.5 8.5 CD cord-010092-uftc8inx 1821 35 % % NN cord-010092-uftc8inx 1821 36 with with IN cord-010092-uftc8inx 1821 37 complete complete JJ cord-010092-uftc8inx 1821 38 depletion depletion NN cord-010092-uftc8inx 1821 39 of of IN cord-010092-uftc8inx 1821 40 iron iron NN cord-010092-uftc8inx 1821 41 stores store NNS cord-010092-uftc8inx 1821 42 , , , cord-010092-uftc8inx 1821 43 representing represent VBG cord-010092-uftc8inx 1821 44 serum serum NN cord-010092-uftc8inx 1821 45 ferritin ferritin NN cord-010092-uftc8inx 1822 1 < < NNP cord-010092-uftc8inx 1822 2 12 12 CD cord-010092-uftc8inx 1822 3 ng ng NNP cord-010092-uftc8inx 1822 4 / / SYM cord-010092-uftc8inx 1822 5 ml ml NN cord-010092-uftc8inx 1822 6 . . . cord-010092-uftc8inx 1823 1 After after IN cord-010092-uftc8inx 1823 2 controlling control VBG cord-010092-uftc8inx 1823 3 for for IN cord-010092-uftc8inx 1823 4 demographic demographic JJ cord-010092-uftc8inx 1823 5 factors factor NNS cord-010092-uftc8inx 1823 6 and and CC cord-010092-uftc8inx 1823 7 donation donation NN cord-010092-uftc8inx 1823 8 frequency frequency NN cord-010092-uftc8inx 1823 9 , , , cord-010092-uftc8inx 1823 10 the the DT cord-010092-uftc8inx 1823 11 lowest low JJS cord-010092-uftc8inx 1823 12 tertile tertile NN cord-010092-uftc8inx 1823 13 of of IN cord-010092-uftc8inx 1823 14 ICS ICS NNP cord-010092-uftc8inx 1823 15 was be VBD cord-010092-uftc8inx 1823 16 associated associate VBN cord-010092-uftc8inx 1823 17 with with IN cord-010092-uftc8inx 1823 18 a a DT cord-010092-uftc8inx 1823 19 greater great JJR cord-010092-uftc8inx 1823 20 than than IN cord-010092-uftc8inx 1823 21 2fold 2fold CD cord-010092-uftc8inx 1823 22 higher high JJR cord-010092-uftc8inx 1823 23 risk risk NN cord-010092-uftc8inx 1823 24 for for IN cord-010092-uftc8inx 1823 25 complete complete JJ cord-010092-uftc8inx 1823 26 iron iron NN cord-010092-uftc8inx 1823 27 depletion depletion NN cord-010092-uftc8inx 1823 28 during during IN cord-010092-uftc8inx 1823 29 all all DT cord-010092-uftc8inx 1823 30 follow follow VB cord-010092-uftc8inx 1823 31 - - HYPH cord-010092-uftc8inx 1823 32 up up RP cord-010092-uftc8inx 1823 33 visits visit NNS cord-010092-uftc8inx 1823 34 ( ( -LRB- cord-010092-uftc8inx 1823 35 RR RR NNP cord-010092-uftc8inx 1823 36 2.40 2.40 CD cord-010092-uftc8inx 1823 37 , , , cord-010092-uftc8inx 1823 38 95 95 CD cord-010092-uftc8inx 1823 39 % % NN cord-010092-uftc8inx 1823 40 CI CI NNP cord-010092-uftc8inx 1823 41 1.51 1.51 CD cord-010092-uftc8inx 1823 42 , , , cord-010092-uftc8inx 1823 43 3.81 3.81 CD cord-010092-uftc8inx 1823 44 , , , cord-010092-uftc8inx 1823 45 compared compare VBN cord-010092-uftc8inx 1823 46 to to IN cord-010092-uftc8inx 1823 47 the the DT cord-010092-uftc8inx 1823 48 highest high JJS cord-010092-uftc8inx 1823 49 tertile tertile NN cord-010092-uftc8inx 1823 50 ) ) -RRB- cord-010092-uftc8inx 1823 51 . . . cord-010092-uftc8inx 1824 1 Summary Summary NNP cord-010092-uftc8inx 1824 2 / / SYM cord-010092-uftc8inx 1824 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 1824 4 : : : cord-010092-uftc8inx 1825 1 In in IN cord-010092-uftc8inx 1825 2 this this DT cord-010092-uftc8inx 1825 3 longitudinal longitudinal JJ cord-010092-uftc8inx 1825 4 evaluation evaluation NN cord-010092-uftc8inx 1825 5 of of IN cord-010092-uftc8inx 1825 6 dietary dietary JJ cord-010092-uftc8inx 1825 7 iron iron NN cord-010092-uftc8inx 1825 8 and and CC cord-010092-uftc8inx 1825 9 iron iron NN cord-010092-uftc8inx 1825 10 status status NN cord-010092-uftc8inx 1825 11 , , , cord-010092-uftc8inx 1825 12 blood blood NN cord-010092-uftc8inx 1825 13 donors donor NNS cord-010092-uftc8inx 1825 14 with with IN cord-010092-uftc8inx 1825 15 low low JJ cord-010092-uftc8inx 1825 16 intake intake NN cord-010092-uftc8inx 1825 17 of of IN cord-010092-uftc8inx 1825 18 heme heme NN cord-010092-uftc8inx 1825 19 iron iron NN cord-010092-uftc8inx 1825 20 had have VBD cord-010092-uftc8inx 1825 21 an an DT cord-010092-uftc8inx 1825 22 elevated elevated JJ cord-010092-uftc8inx 1825 23 risk risk NN cord-010092-uftc8inx 1825 24 for for IN cord-010092-uftc8inx 1825 25 developing develop VBG cord-010092-uftc8inx 1825 26 advanced advanced JJ cord-010092-uftc8inx 1825 27 iron iron NN cord-010092-uftc8inx 1825 28 depletion depletion NN cord-010092-uftc8inx 1825 29 . . . cord-010092-uftc8inx 1826 1 These these DT cord-010092-uftc8inx 1826 2 results result NNS cord-010092-uftc8inx 1826 3 suggest suggest VBP cord-010092-uftc8inx 1826 4 that that IN cord-010092-uftc8inx 1826 5 blood blood NN cord-010092-uftc8inx 1826 6 centers center NNS cord-010092-uftc8inx 1826 7 should should MD cord-010092-uftc8inx 1826 8 continue continue VB cord-010092-uftc8inx 1826 9 to to TO cord-010092-uftc8inx 1826 10 recommend recommend VB cord-010092-uftc8inx 1826 11 iron iron NN cord-010092-uftc8inx 1826 12 - - HYPH cord-010092-uftc8inx 1826 13 rich rich JJ cord-010092-uftc8inx 1826 14 diets diet NNS cord-010092-uftc8inx 1826 15 to to TO cord-010092-uftc8inx 1826 16 repeat repeat VB cord-010092-uftc8inx 1826 17 blood blood NN cord-010092-uftc8inx 1826 18 donors donor NNS cord-010092-uftc8inx 1826 19 . . . cord-010092-uftc8inx 1827 1 Background background NN cord-010092-uftc8inx 1827 2 : : : cord-010092-uftc8inx 1828 1 Blood blood NN cord-010092-uftc8inx 1828 2 donors donor NNS cord-010092-uftc8inx 1828 3 lose lose VBP cord-010092-uftc8inx 1828 4 approximately approximately RB cord-010092-uftc8inx 1828 5 250 250 CD cord-010092-uftc8inx 1828 6 mg mg NN cord-010092-uftc8inx 1828 7 of of IN cord-010092-uftc8inx 1828 8 iron iron NN cord-010092-uftc8inx 1828 9 with with IN cord-010092-uftc8inx 1828 10 every every DT cord-010092-uftc8inx 1828 11 blood blood NN cord-010092-uftc8inx 1828 12 donation donation NN cord-010092-uftc8inx 1828 13 . . . cord-010092-uftc8inx 1829 1 As as IN cord-010092-uftc8inx 1829 2 a a DT cord-010092-uftc8inx 1829 3 result result NN cord-010092-uftc8inx 1829 4 , , , cord-010092-uftc8inx 1829 5 frequent frequent JJ cord-010092-uftc8inx 1829 6 blood blood NN cord-010092-uftc8inx 1829 7 donors donor NNS cord-010092-uftc8inx 1829 8 are be VBP cord-010092-uftc8inx 1829 9 at at IN cord-010092-uftc8inx 1829 10 risk risk NN cord-010092-uftc8inx 1829 11 of of IN cord-010092-uftc8inx 1829 12 iron iron NN cord-010092-uftc8inx 1829 13 deficiency deficiency NN cord-010092-uftc8inx 1829 14 and and CC cord-010092-uftc8inx 1829 15 low low JJ cord-010092-uftc8inx 1829 16 hemoglobin hemoglobin NN cord-010092-uftc8inx 1829 17 ( ( -LRB- cord-010092-uftc8inx 1829 18 Hb Hb NNP cord-010092-uftc8inx 1829 19 ) ) -RRB- cord-010092-uftc8inx 1829 20 levels level NNS cord-010092-uftc8inx 1829 21 , , , cord-010092-uftc8inx 1829 22 which which WDT cord-010092-uftc8inx 1829 23 may may MD cord-010092-uftc8inx 1829 24 affect affect VB cord-010092-uftc8inx 1829 25 their -PRON- PRP$ cord-010092-uftc8inx 1829 26 health health NN cord-010092-uftc8inx 1829 27 and and CC cord-010092-uftc8inx 1829 28 eligibility eligibility NN cord-010092-uftc8inx 1829 29 to to TO cord-010092-uftc8inx 1829 30 donate donate VB cord-010092-uftc8inx 1829 31 . . . cord-010092-uftc8inx 1830 1 Lifestyle lifestyle NN cord-010092-uftc8inx 1830 2 behaviors behavior NNS cord-010092-uftc8inx 1830 3 such such JJ cord-010092-uftc8inx 1830 4 as as IN cord-010092-uftc8inx 1830 5 dietary dietary JJ cord-010092-uftc8inx 1830 6 iron iron NN cord-010092-uftc8inx 1830 7 intake intake NN cord-010092-uftc8inx 1830 8 and and CC cord-010092-uftc8inx 1830 9 physical physical JJ cord-010092-uftc8inx 1830 10 activity activity NN cord-010092-uftc8inx 1830 11 , , , cord-010092-uftc8inx 1830 12 may may MD cord-010092-uftc8inx 1830 13 influence influence VB cord-010092-uftc8inx 1830 14 iron iron NN cord-010092-uftc8inx 1830 15 stores store NNS cord-010092-uftc8inx 1830 16 and and CC cord-010092-uftc8inx 1830 17 thereby thereby RB cord-010092-uftc8inx 1830 18 Hb Hb NNP cord-010092-uftc8inx 1830 19 levels level NNS cord-010092-uftc8inx 1830 20 . . . cord-010092-uftc8inx 1831 1 Gaining gain VBG cord-010092-uftc8inx 1831 2 insight insight NN cord-010092-uftc8inx 1831 3 into into IN cord-010092-uftc8inx 1831 4 associations association NNS cord-010092-uftc8inx 1831 5 between between IN cord-010092-uftc8inx 1831 6 lifestyle lifestyle NN cord-010092-uftc8inx 1831 7 behaviors behavior NNS cord-010092-uftc8inx 1831 8 and and CC cord-010092-uftc8inx 1831 9 Hb Hb NNP cord-010092-uftc8inx 1831 10 levels level NNS cord-010092-uftc8inx 1831 11 is be VBZ cord-010092-uftc8inx 1831 12 valuable valuable JJ cord-010092-uftc8inx 1831 13 for for IN cord-010092-uftc8inx 1831 14 blood blood NN cord-010092-uftc8inx 1831 15 supply supply NN cord-010092-uftc8inx 1831 16 organizations organization NNS cord-010092-uftc8inx 1831 17 , , , cord-010092-uftc8inx 1831 18 as as IN cord-010092-uftc8inx 1831 19 lifestyle lifestyle NN cord-010092-uftc8inx 1831 20 behaviors behavior NNS cord-010092-uftc8inx 1831 21 can can MD cord-010092-uftc8inx 1831 22 potentially potentially RB cord-010092-uftc8inx 1831 23 be be VB cord-010092-uftc8inx 1831 24 considered consider VBN cord-010092-uftc8inx 1831 25 to to TO cord-010092-uftc8inx 1831 26 prevent prevent VB cord-010092-uftc8inx 1831 27 Hb Hb NNP cord-010092-uftc8inx 1831 28 deferrals deferral NNS cord-010092-uftc8inx 1831 29 . . . cord-010092-uftc8inx 1832 1 Examining examine VBG cord-010092-uftc8inx 1832 2 the the DT cord-010092-uftc8inx 1832 3 mediating mediating JJ cord-010092-uftc8inx 1832 4 role role NN cord-010092-uftc8inx 1832 5 of of IN cord-010092-uftc8inx 1832 6 ferritin ferritin NN cord-010092-uftc8inx 1832 7 , , , cord-010092-uftc8inx 1832 8 a a DT cord-010092-uftc8inx 1832 9 measure measure NN cord-010092-uftc8inx 1832 10 reflecting reflect VBG cord-010092-uftc8inx 1832 11 iron iron NN cord-010092-uftc8inx 1832 12 stores store NNS cord-010092-uftc8inx 1832 13 , , , cord-010092-uftc8inx 1832 14 in in IN cord-010092-uftc8inx 1832 15 these these DT cord-010092-uftc8inx 1832 16 associations association NNS cord-010092-uftc8inx 1832 17 will will MD cord-010092-uftc8inx 1832 18 help help VB cord-010092-uftc8inx 1832 19 to to TO cord-010092-uftc8inx 1832 20 gain gain VB cord-010092-uftc8inx 1832 21 insight insight NN cord-010092-uftc8inx 1832 22 into into IN cord-010092-uftc8inx 1832 23 whether whether IN cord-010092-uftc8inx 1832 24 iron iron NN cord-010092-uftc8inx 1832 25 stores store NNS cord-010092-uftc8inx 1832 26 could could MD cord-010092-uftc8inx 1832 27 be be VB cord-010092-uftc8inx 1832 28 the the DT cord-010092-uftc8inx 1832 29 limiting limit VBG cord-010092-uftc8inx 1832 30 or or CC cord-010092-uftc8inx 1832 31 enabling enable VBG cord-010092-uftc8inx 1832 32 factor factor NN cord-010092-uftc8inx 1832 33 that that WDT cord-010092-uftc8inx 1832 34 links link VBZ cord-010092-uftc8inx 1832 35 lifestyle lifestyle NN cord-010092-uftc8inx 1832 36 behaviors behavior NNS cord-010092-uftc8inx 1832 37 to to IN cord-010092-uftc8inx 1832 38 Hb Hb NNP cord-010092-uftc8inx 1832 39 recovery recovery NN cord-010092-uftc8inx 1832 40 after after IN cord-010092-uftc8inx 1832 41 donation donation NN cord-010092-uftc8inx 1832 42 . . . cord-010092-uftc8inx 1833 1 Aims aim VBZ cord-010092-uftc8inx 1833 2 : : : cord-010092-uftc8inx 1833 3 To to TO cord-010092-uftc8inx 1833 4 investigate investigate VB cord-010092-uftc8inx 1833 5 associations association NNS cord-010092-uftc8inx 1833 6 between between IN cord-010092-uftc8inx 1833 7 lifestyle lifestyle NN cord-010092-uftc8inx 1833 8 behaviors behavior NNS cord-010092-uftc8inx 1833 9 ( ( -LRB- cord-010092-uftc8inx 1833 10 dietary dietary JJ cord-010092-uftc8inx 1833 11 heme heme NN cord-010092-uftc8inx 1833 12 and and CC cord-010092-uftc8inx 1833 13 non non JJ cord-010092-uftc8inx 1833 14 - - JJ cord-010092-uftc8inx 1833 15 heme heme JJ cord-010092-uftc8inx 1833 16 iron iron NN cord-010092-uftc8inx 1833 17 intake intake NN cord-010092-uftc8inx 1833 18 and and CC cord-010092-uftc8inx 1833 19 physical physical JJ cord-010092-uftc8inx 1833 20 activity activity NN cord-010092-uftc8inx 1833 21 ) ) -RRB- cord-010092-uftc8inx 1833 22 and and CC cord-010092-uftc8inx 1833 23 Hb Hb NNP cord-010092-uftc8inx 1833 24 levels level NNS cord-010092-uftc8inx 1833 25 , , , cord-010092-uftc8inx 1833 26 and and CC cord-010092-uftc8inx 1833 27 whether whether IN cord-010092-uftc8inx 1833 28 ferritin ferritin NN cord-010092-uftc8inx 1833 29 mediates mediate VBZ cord-010092-uftc8inx 1833 30 these these DT cord-010092-uftc8inx 1833 31 associations association NNS cord-010092-uftc8inx 1833 32 . . . cord-010092-uftc8inx 1834 1 Methods method NNS cord-010092-uftc8inx 1834 2 : : : cord-010092-uftc8inx 1834 3 Donor Donor NNP cord-010092-uftc8inx 1834 4 InSight InSight NNP cord-010092-uftc8inx 1834 5 - - HYPH cord-010092-uftc8inx 1834 6 III III NNP cord-010092-uftc8inx 1834 7 ( ( -LRB- cord-010092-uftc8inx 1834 8 DIS DIS NNP cord-010092-uftc8inx 1834 9 - - HYPH cord-010092-uftc8inx 1834 10 III III NNP cord-010092-uftc8inx 1834 11 ) ) -RRB- cord-010092-uftc8inx 1834 12 is be VBZ cord-010092-uftc8inx 1834 13 a a DT cord-010092-uftc8inx 1834 14 Dutch dutch JJ cord-010092-uftc8inx 1834 15 cohort cohort NN cord-010092-uftc8inx 1834 16 study study NN cord-010092-uftc8inx 1834 17 of of IN cord-010092-uftc8inx 1834 18 blood blood NN cord-010092-uftc8inx 1834 19 and and CC cord-010092-uftc8inx 1834 20 plasma plasma NN cord-010092-uftc8inx 1834 21 donors donor NNS cord-010092-uftc8inx 1834 22 and and CC cord-010092-uftc8inx 1834 23 included include VBD cord-010092-uftc8inx 1834 24 2,552 2,552 CD cord-010092-uftc8inx 1834 25 donors donor NNS cord-010092-uftc8inx 1834 26 . . . cord-010092-uftc8inx 1835 1 Participants participant NNS cord-010092-uftc8inx 1835 2 who who WP cord-010092-uftc8inx 1835 3 were be VBD cord-010092-uftc8inx 1835 4 pregnant pregnant JJ cord-010092-uftc8inx 1835 5 , , , cord-010092-uftc8inx 1835 6 had have VBD cord-010092-uftc8inx 1835 7 hemochromatosis hemochromatosis NN cord-010092-uftc8inx 1835 8 , , , cord-010092-uftc8inx 1835 9 used use VBN cord-010092-uftc8inx 1835 10 iron iron NN cord-010092-uftc8inx 1835 11 supplements supplement NNS cord-010092-uftc8inx 1835 12 / / SYM cord-010092-uftc8inx 1835 13 medication medication NN cord-010092-uftc8inx 1835 14 , , , cord-010092-uftc8inx 1835 15 got get VBD cord-010092-uftc8inx 1836 1 a a DT cord-010092-uftc8inx 1836 2 hysterectomy hysterectomy NN cord-010092-uftc8inx 1836 3 or or CC cord-010092-uftc8inx 1836 4 bilateral bilateral JJ cord-010092-uftc8inx 1836 5 oophorectomy oophorectomy NN cord-010092-uftc8inx 1836 6 were be VBD cord-010092-uftc8inx 1836 7 excluded exclude VBN cord-010092-uftc8inx 1836 8 ( ( -LRB- cord-010092-uftc8inx 1836 9 n n NN cord-010092-uftc8inx 1836 10 = = SYM cord-010092-uftc8inx 1836 11 292 292 CD cord-010092-uftc8inx 1836 12 ) ) -RRB- cord-010092-uftc8inx 1836 13 . . . cord-010092-uftc8inx 1837 1 Hb Hb NNP cord-010092-uftc8inx 1837 2 levels level NNS cord-010092-uftc8inx 1837 3 were be VBD cord-010092-uftc8inx 1837 4 measured measure VBN cord-010092-uftc8inx 1837 5 in in IN cord-010092-uftc8inx 1837 6 EDTA EDTA NNP cord-010092-uftc8inx 1837 7 whole whole JJ cord-010092-uftc8inx 1837 8 blood blood NN cord-010092-uftc8inx 1837 9 samples sample NNS cord-010092-uftc8inx 1837 10 using use VBG cord-010092-uftc8inx 1837 11 a a DT cord-010092-uftc8inx 1837 12 hematology hematology NN cord-010092-uftc8inx 1837 13 analyzer analyzer NN cord-010092-uftc8inx 1837 14 ( ( -LRB- cord-010092-uftc8inx 1837 15 XT-2000 xt-2000 NN cord-010092-uftc8inx 1837 16 , , , cord-010092-uftc8inx 1837 17 Sysmex Sysmex NNP cord-010092-uftc8inx 1837 18 , , , cord-010092-uftc8inx 1837 19 Japan Japan NNP cord-010092-uftc8inx 1837 20 ) ) -RRB- cord-010092-uftc8inx 1837 21 and and CC cord-010092-uftc8inx 1837 22 ferritin ferritin NN cord-010092-uftc8inx 1837 23 was be VBD cord-010092-uftc8inx 1837 24 measured measure VBN cord-010092-uftc8inx 1837 25 in in IN cord-010092-uftc8inx 1837 26 plasma plasma NN cord-010092-uftc8inx 1837 27 from from IN cord-010092-uftc8inx 1837 28 lithium lithium NN cord-010092-uftc8inx 1837 29 heparin heparin NN cord-010092-uftc8inx 1837 30 tubes tube NNS cord-010092-uftc8inx 1837 31 ( ( -LRB- cord-010092-uftc8inx 1837 32 Architect Architect NNP cord-010092-uftc8inx 1837 33 Ci8200 Ci8200 NNP cord-010092-uftc8inx 1837 34 , , , cord-010092-uftc8inx 1837 35 Abbott Abbott NNP cord-010092-uftc8inx 1837 36 Laboratories Laboratories NNP cord-010092-uftc8inx 1837 37 , , , cord-010092-uftc8inx 1837 38 U.S.A. U.S.A. NNP cord-010092-uftc8inx 1837 39 ) ) -RRB- cord-010092-uftc8inx 1837 40 . . . cord-010092-uftc8inx 1838 1 Dietary dietary JJ cord-010092-uftc8inx 1838 2 heme heme NN cord-010092-uftc8inx 1838 3 and and CC cord-010092-uftc8inx 1838 4 non non JJ cord-010092-uftc8inx 1838 5 - - JJ cord-010092-uftc8inx 1838 6 heme heme JJ cord-010092-uftc8inx 1838 7 iron iron NN cord-010092-uftc8inx 1838 8 intake intake NN cord-010092-uftc8inx 1838 9 ( ( -LRB- cord-010092-uftc8inx 1838 10 grams gram NNS cord-010092-uftc8inx 1838 11 / / SYM cord-010092-uftc8inx 1838 12 day day NN cord-010092-uftc8inx 1838 13 ) ) -RRB- cord-010092-uftc8inx 1838 14 were be VBD cord-010092-uftc8inx 1838 15 assessed assess VBN cord-010092-uftc8inx 1838 16 using use VBG cord-010092-uftc8inx 1838 17 a a DT cord-010092-uftc8inx 1838 18 food food NN cord-010092-uftc8inx 1838 19 frequency frequency NN cord-010092-uftc8inx 1838 20 questionnaire questionnaire NN cord-010092-uftc8inx 1838 21 adapted adapt VBN cord-010092-uftc8inx 1838 22 to to TO cord-010092-uftc8inx 1838 23 measure measure VB cord-010092-uftc8inx 1838 24 iron iron NN cord-010092-uftc8inx 1838 25 intake intake NN cord-010092-uftc8inx 1838 26 . . . cord-010092-uftc8inx 1839 1 Moderate moderate JJ cord-010092-uftc8inx 1839 2 - - HYPH cord-010092-uftc8inx 1839 3 tovigorous tovigorous JJ cord-010092-uftc8inx 1839 4 physical physical JJ cord-010092-uftc8inx 1839 5 activity activity NN cord-010092-uftc8inx 1839 6 ( ( -LRB- cord-010092-uftc8inx 1839 7 MVPA MVPA NNP cord-010092-uftc8inx 1839 8 , , , cord-010092-uftc8inx 1839 9 minutes minute NNS cord-010092-uftc8inx 1839 10 / / SYM cord-010092-uftc8inx 1839 11 day day NN cord-010092-uftc8inx 1839 12 ) ) -RRB- cord-010092-uftc8inx 1839 13 was be VBD cord-010092-uftc8inx 1839 14 assessed assess VBN cord-010092-uftc8inx 1839 15 using use VBG cord-010092-uftc8inx 1839 16 the the DT cord-010092-uftc8inx 1839 17 International International NNP cord-010092-uftc8inx 1839 18 Physical Physical NNP cord-010092-uftc8inx 1839 19 Activity Activity NNP cord-010092-uftc8inx 1839 20 Questionnaire Questionnaire NNP cord-010092-uftc8inx 1839 21 ( ( -LRB- cord-010092-uftc8inx 1839 22 IPAQ)-Short IPAQ)-Short NNP cord-010092-uftc8inx 1839 23 Form Form NNP cord-010092-uftc8inx 1839 24 . . . cord-010092-uftc8inx 1840 1 Results result NNS cord-010092-uftc8inx 1840 2 : : : cord-010092-uftc8inx 1841 1 In in IN cord-010092-uftc8inx 1841 2 total total JJ cord-010092-uftc8inx 1841 3 , , , cord-010092-uftc8inx 1841 4 2,260 2,260 CD cord-010092-uftc8inx 1841 5 ( ( -LRB- cord-010092-uftc8inx 1841 6 1,186 1,186 CD cord-010092-uftc8inx 1841 7 female female JJ cord-010092-uftc8inx 1841 8 ) ) -RRB- cord-010092-uftc8inx 1841 9 participants participant NNS cord-010092-uftc8inx 1841 10 were be VBD cord-010092-uftc8inx 1841 11 included include VBN cord-010092-uftc8inx 1841 12 . . . cord-010092-uftc8inx 1842 1 Donors donor NNS cord-010092-uftc8inx 1842 2 with with IN cord-010092-uftc8inx 1842 3 higher high JJR cord-010092-uftc8inx 1842 4 intakes intake NNS cord-010092-uftc8inx 1842 5 of of IN cord-010092-uftc8inx 1842 6 heme heme NN cord-010092-uftc8inx 1842 7 iron iron NN cord-010092-uftc8inx 1842 8 had have VBD cord-010092-uftc8inx 1842 9 significantly significantly RB cord-010092-uftc8inx 1842 10 higher high JJR cord-010092-uftc8inx 1842 11 Hb Hb NNP cord-010092-uftc8inx 1842 12 levels level NNS cord-010092-uftc8inx 1842 13 ( ( -LRB- cord-010092-uftc8inx 1842 14 regression regression NN cord-010092-uftc8inx 1842 15 coefficient coefficient NN cord-010092-uftc8inx 1842 16 ( ( -LRB- cord-010092-uftc8inx 1842 17 b b NN cord-010092-uftc8inx 1842 18 ) ) -RRB- cord-010092-uftc8inx 1842 19 ( ( -LRB- cord-010092-uftc8inx 1842 20 95 95 CD cord-010092-uftc8inx 1842 21 % % NN cord-010092-uftc8inx 1842 22 confidence confidence NN cord-010092-uftc8inx 1842 23 interval interval NN cord-010092-uftc8inx 1842 24 ( ( -LRB- cord-010092-uftc8inx 1842 25 95 95 CD cord-010092-uftc8inx 1842 26 % % NN cord-010092-uftc8inx 1842 27 CI CI NNP cord-010092-uftc8inx 1842 28 ) ) -RRB- cord-010092-uftc8inx 1842 29 ) ) -RRB- cord-010092-uftc8inx 1842 30 in in IN cord-010092-uftc8inx 1842 31 men man NNS cord-010092-uftc8inx 1842 32 and and CC cord-010092-uftc8inx 1842 33 women woman NNS cord-010092-uftc8inx 1842 34 respectively respectively RB cord-010092-uftc8inx 1842 35 : : : cord-010092-uftc8inx 1842 36 0.147 0.147 CD cord-010092-uftc8inx 1842 37 ( ( -LRB- cord-010092-uftc8inx 1842 38 0.069 0.069 CD cord-010092-uftc8inx 1842 39 to to IN cord-010092-uftc8inx 1842 40 0.225 0.225 CD cord-010092-uftc8inx 1842 41 ) ) -RRB- cord-010092-uftc8inx 1842 42 and and CC cord-010092-uftc8inx 1842 43 0.094 0.094 CD cord-010092-uftc8inx 1842 44 ( ( -LRB- cord-010092-uftc8inx 1842 45 0.013 0.013 CD cord-010092-uftc8inx 1842 46 to to IN cord-010092-uftc8inx 1842 47 0.175 0.175 CD cord-010092-uftc8inx 1842 48 ) ) -RRB- cord-010092-uftc8inx 1843 1 mmol mmol NNP cord-010092-uftc8inx 1843 2 / / SYM cord-010092-uftc8inx 1843 3 L L NNP cord-010092-uftc8inx 1843 4 ) ) -RRB- cord-010092-uftc8inx 1843 5 , , , cord-010092-uftc8inx 1843 6 independent independent JJ cord-010092-uftc8inx 1843 7 of of IN cord-010092-uftc8inx 1843 8 age age NN cord-010092-uftc8inx 1843 9 , , , cord-010092-uftc8inx 1843 10 smoking smoking NN cord-010092-uftc8inx 1843 11 , , , cord-010092-uftc8inx 1843 12 menstruation menstruation NN cord-010092-uftc8inx 1843 13 , , , cord-010092-uftc8inx 1843 14 number number NN cord-010092-uftc8inx 1843 15 of of IN cord-010092-uftc8inx 1843 16 donations donation NNS cord-010092-uftc8inx 1843 17 in in IN cord-010092-uftc8inx 1843 18 previous previous JJ cord-010092-uftc8inx 1843 19 two two CD cord-010092-uftc8inx 1843 20 years year NNS cord-010092-uftc8inx 1843 21 , , , cord-010092-uftc8inx 1843 22 donation donation NN cord-010092-uftc8inx 1843 23 interval interval NN cord-010092-uftc8inx 1843 24 , , , cord-010092-uftc8inx 1843 25 sedentary sedentary JJ cord-010092-uftc8inx 1843 26 behavior behavior NN cord-010092-uftc8inx 1843 27 , , , cord-010092-uftc8inx 1843 28 the the DT cord-010092-uftc8inx 1843 29 other other JJ cord-010092-uftc8inx 1843 30 lifestyle lifestyle NN cord-010092-uftc8inx 1843 31 variable variable NN cord-010092-uftc8inx 1843 32 ( ( -LRB- cord-010092-uftc8inx 1843 33 i.e. i.e. FW cord-010092-uftc8inx 1843 34 ( ( -LRB- cord-010092-uftc8inx 1843 35 non-)heme non-)heme NNP cord-010092-uftc8inx 1843 36 iron iron NN cord-010092-uftc8inx 1843 37 intake intake NN cord-010092-uftc8inx 1843 38 or or CC cord-010092-uftc8inx 1843 39 MVPA MVPA NNP cord-010092-uftc8inx 1843 40 ) ) -RRB- cord-010092-uftc8inx 1843 41 , , , cord-010092-uftc8inx 1843 42 and and CC cord-010092-uftc8inx 1843 43 initial initial JJ cord-010092-uftc8inx 1843 44 Hb Hb NNP cord-010092-uftc8inx 1843 45 level level NN cord-010092-uftc8inx 1843 46 . . . cord-010092-uftc8inx 1844 1 Non non JJ cord-010092-uftc8inx 1844 2 - - JJ cord-010092-uftc8inx 1844 3 heme heme JJ cord-010092-uftc8inx 1844 4 iron iron NN cord-010092-uftc8inx 1844 5 intake intake NN cord-010092-uftc8inx 1844 6 was be VBD cord-010092-uftc8inx 1844 7 negatively negatively RB cord-010092-uftc8inx 1844 8 associated associate VBN cord-010092-uftc8inx 1844 9 with with IN cord-010092-uftc8inx 1844 10 Hb Hb NNP cord-010092-uftc8inx 1844 11 levels level NNS cord-010092-uftc8inx 1844 12 ( ( -LRB- cord-010092-uftc8inx 1844 13 -0.015 -0.015 . cord-010092-uftc8inx 1845 1 ( ( -LRB- cord-010092-uftc8inx 1845 2 -0.026 -0.026 VB cord-010092-uftc8inx 1845 3 to to IN cord-010092-uftc8inx 1845 4 -0.004 -0.004 ADD cord-010092-uftc8inx 1845 5 ) ) -RRB- cord-010092-uftc8inx 1846 1 and and CC cord-010092-uftc8inx 1847 1 -0.018 -0.018 NFP cord-010092-uftc8inx 1847 2 ( ( -LRB- cord-010092-uftc8inx 1847 3 -0.032 -0.032 NNP cord-010092-uftc8inx 1847 4 to to IN cord-010092-uftc8inx 1847 5 -0.005 -0.005 NNP cord-010092-uftc8inx 1847 6 ) ) -RRB- cord-010092-uftc8inx 1847 7 mmol mmol NN cord-010092-uftc8inx 1847 8 / / SYM cord-010092-uftc8inx 1847 9 L l NN cord-010092-uftc8inx 1847 10 for for IN cord-010092-uftc8inx 1847 11 men man NNS cord-010092-uftc8inx 1847 12 and and CC cord-010092-uftc8inx 1847 13 women woman NNS cord-010092-uftc8inx 1847 14 respectively respectively RB cord-010092-uftc8inx 1847 15 ) ) -RRB- cord-010092-uftc8inx 1847 16 . . . cord-010092-uftc8inx 1848 1 Ferritin ferritin NN cord-010092-uftc8inx 1848 2 mediated mediate VBD cord-010092-uftc8inx 1848 3 associations association NNS cord-010092-uftc8inx 1848 4 between between IN cord-010092-uftc8inx 1848 5 dietary dietary JJ cord-010092-uftc8inx 1848 6 iron iron NN cord-010092-uftc8inx 1848 7 intake intake NN cord-010092-uftc8inx 1848 8 and and CC cord-010092-uftc8inx 1848 9 Hb Hb NNP cord-010092-uftc8inx 1848 10 levels level NNS cord-010092-uftc8inx 1848 11 ( ( -LRB- cord-010092-uftc8inx 1848 12 indirect indirect JJ cord-010092-uftc8inx 1848 13 effect effect NN cord-010092-uftc8inx 1848 14 in in IN cord-010092-uftc8inx 1848 15 men man NNS cord-010092-uftc8inx 1848 16 and and CC cord-010092-uftc8inx 1848 17 women woman NNS cord-010092-uftc8inx 1848 18 respectively respectively RB cord-010092-uftc8inx 1848 19 : : : cord-010092-uftc8inx 1848 20 0.073 0.073 CD cord-010092-uftc8inx 1848 21 ( ( -LRB- cord-010092-uftc8inx 1848 22 0.046 0.046 CD cord-010092-uftc8inx 1848 23 to to IN cord-010092-uftc8inx 1848 24 0.107 0.107 CD cord-010092-uftc8inx 1848 25 ) ) -RRB- cord-010092-uftc8inx 1848 26 and and CC cord-010092-uftc8inx 1848 27 0.065 0.065 CD cord-010092-uftc8inx 1848 28 ( ( -LRB- cord-010092-uftc8inx 1848 29 0.031 0.031 CD cord-010092-uftc8inx 1848 30 to to IN cord-010092-uftc8inx 1848 31 0.100 0.100 CD cord-010092-uftc8inx 1848 32 ) ) -RRB- cord-010092-uftc8inx 1849 1 lg lg NNP cord-010092-uftc8inx 1849 2 / / SYM cord-010092-uftc8inx 1849 3 L L NNP cord-010092-uftc8inx 1849 4 for for IN cord-010092-uftc8inx 1849 5 heme heme NN cord-010092-uftc8inx 1849 6 and and CC cord-010092-uftc8inx 1849 7 -0.003 -0.003 NN cord-010092-uftc8inx 1850 1 ( ( -LRB- cord-010092-uftc8inx 1850 2 -0.008 -0.008 VB cord-010092-uftc8inx 1850 3 to to IN cord-010092-uftc8inx 1850 4 0.000 0.000 CD cord-010092-uftc8inx 1850 5 ) ) -RRB- cord-010092-uftc8inx 1851 1 and and CC cord-010092-uftc8inx 1851 2 -0.007 -0.007 NNP cord-010092-uftc8inx 1851 3 ( ( -LRB- cord-010092-uftc8inx 1851 4 -0.013 -0.013 NNP cord-010092-uftc8inx 1851 5 to to IN cord-010092-uftc8inx 1851 6 -0.002 -0.002 NNP cord-010092-uftc8inx 1851 7 ) ) -RRB- cord-010092-uftc8inx 1851 8 for for IN cord-010092-uftc8inx 1851 9 non non JJ cord-010092-uftc8inx 1851 10 - - JJ cord-010092-uftc8inx 1851 11 heme heme JJ cord-010092-uftc8inx 1851 12 ) ) -RRB- cord-010092-uftc8inx 1851 13 . . . cord-010092-uftc8inx 1852 1 More More JJR cord-010092-uftc8inx 1852 2 MVPA MVPA NNP cord-010092-uftc8inx 1852 3 was be VBD cord-010092-uftc8inx 1852 4 negatively negatively RB cord-010092-uftc8inx 1852 5 associated associate VBN cord-010092-uftc8inx 1852 6 with with IN cord-010092-uftc8inx 1852 7 Hb Hb NNP cord-010092-uftc8inx 1852 8 levels level NNS cord-010092-uftc8inx 1852 9 in in IN cord-010092-uftc8inx 1852 10 men man NNS cord-010092-uftc8inx 1852 11 only only RB cord-010092-uftc8inx 1853 1 ( ( -LRB- cord-010092-uftc8inx 1853 2 -0.004 -0.004 NNP cord-010092-uftc8inx 1854 1 ( ( -LRB- cord-010092-uftc8inx 1854 2 -0.008 -0.008 VB cord-010092-uftc8inx 1854 3 to to IN cord-010092-uftc8inx 1854 4 -0.001 -0.001 NNP cord-010092-uftc8inx 1854 5 ) ) -RRB- cord-010092-uftc8inx 1854 6 ) ) -RRB- cord-010092-uftc8inx 1855 1 , , , cord-010092-uftc8inx 1855 2 which which WDT cord-010092-uftc8inx 1855 3 was be VBD cord-010092-uftc8inx 1855 4 not not RB cord-010092-uftc8inx 1855 5 mediated mediate VBN cord-010092-uftc8inx 1855 6 by by IN cord-010092-uftc8inx 1855 7 ferritin ferritin NN cord-010092-uftc8inx 1855 8 . . . cord-010092-uftc8inx 1856 1 Summary Summary NNP cord-010092-uftc8inx 1856 2 / / SYM cord-010092-uftc8inx 1856 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 1856 4 : : : cord-010092-uftc8inx 1857 1 In in IN cord-010092-uftc8inx 1857 2 conclusion conclusion NN cord-010092-uftc8inx 1857 3 , , , cord-010092-uftc8inx 1857 4 higher high JJR cord-010092-uftc8inx 1857 5 heme heme NN cord-010092-uftc8inx 1857 6 and and CC cord-010092-uftc8inx 1857 7 lower low JJR cord-010092-uftc8inx 1857 8 non non JJ cord-010092-uftc8inx 1857 9 - - JJ cord-010092-uftc8inx 1857 10 heme heme JJ cord-010092-uftc8inx 1857 11 iron iron NN cord-010092-uftc8inx 1857 12 consumption consumption NN cord-010092-uftc8inx 1857 13 are be VBP cord-010092-uftc8inx 1857 14 associated associate VBN cord-010092-uftc8inx 1857 15 with with IN cord-010092-uftc8inx 1857 16 higher high JJR cord-010092-uftc8inx 1857 17 Hb Hb NNP cord-010092-uftc8inx 1857 18 levels level NNS cord-010092-uftc8inx 1857 19 in in IN cord-010092-uftc8inx 1857 20 donors donor NNS cord-010092-uftc8inx 1857 21 via via IN cord-010092-uftc8inx 1857 22 higher high JJR cord-010092-uftc8inx 1857 23 ferritin ferritin NN cord-010092-uftc8inx 1857 24 levels level NNS cord-010092-uftc8inx 1857 25 , , , cord-010092-uftc8inx 1857 26 indicating indicate VBG cord-010092-uftc8inx 1857 27 that that IN cord-010092-uftc8inx 1857 28 donors donor NNS cord-010092-uftc8inx 1857 29 with with IN cord-010092-uftc8inx 1857 30 high high JJ cord-010092-uftc8inx 1857 31 heme heme NN cord-010092-uftc8inx 1857 32 iron iron NN cord-010092-uftc8inx 1857 33 consumption consumption NN cord-010092-uftc8inx 1857 34 may may MD cord-010092-uftc8inx 1857 35 be be VB cord-010092-uftc8inx 1857 36 more more RBR cord-010092-uftc8inx 1857 37 capable capable JJ cord-010092-uftc8inx 1857 38 of of IN cord-010092-uftc8inx 1857 39 maintaining maintain VBG cord-010092-uftc8inx 1857 40 iron iron NN cord-010092-uftc8inx 1857 41 stores store NNS cord-010092-uftc8inx 1857 42 to to TO cord-010092-uftc8inx 1857 43 recover recover VB cord-010092-uftc8inx 1857 44 Hb Hb NNP cord-010092-uftc8inx 1857 45 levels level NNS cord-010092-uftc8inx 1857 46 after after IN cord-010092-uftc8inx 1857 47 blood blood NN cord-010092-uftc8inx 1857 48 donation donation NN cord-010092-uftc8inx 1857 49 . . . cord-010092-uftc8inx 1858 1 More More JJR cord-010092-uftc8inx 1858 2 MVPA MVPA NNP cord-010092-uftc8inx 1858 3 was be VBD cord-010092-uftc8inx 1858 4 associated associate VBN cord-010092-uftc8inx 1858 5 with with IN cord-010092-uftc8inx 1858 6 lower low JJR cord-010092-uftc8inx 1858 7 Hb Hb NNP cord-010092-uftc8inx 1858 8 levels level NNS cord-010092-uftc8inx 1858 9 , , , cord-010092-uftc8inx 1858 10 although although IN cord-010092-uftc8inx 1858 11 effect effect NN cord-010092-uftc8inx 1858 12 sizes size NNS cord-010092-uftc8inx 1858 13 were be VBD cord-010092-uftc8inx 1858 14 small small JJ cord-010092-uftc8inx 1858 15 , , , cord-010092-uftc8inx 1858 16 independent independent JJ cord-010092-uftc8inx 1858 17 of of IN cord-010092-uftc8inx 1858 18 ferritin ferritin NN cord-010092-uftc8inx 1858 19 . . . cord-010092-uftc8inx 1859 1 Taking take VBG cord-010092-uftc8inx 1859 2 a a DT cord-010092-uftc8inx 1859 3 donor donor NN cord-010092-uftc8inx 1859 4 's 's POS cord-010092-uftc8inx 1859 5 lifestyle lifestyle NN cord-010092-uftc8inx 1859 6 behaviors behavior NNS cord-010092-uftc8inx 1859 7 into into IN cord-010092-uftc8inx 1859 8 account account NN cord-010092-uftc8inx 1859 9 may may MD cord-010092-uftc8inx 1859 10 be be VB cord-010092-uftc8inx 1859 11 useful useful JJ cord-010092-uftc8inx 1859 12 in in IN cord-010092-uftc8inx 1859 13 preventing prevent VBG cord-010092-uftc8inx 1859 14 low low JJ cord-010092-uftc8inx 1859 15 Hb Hb NNP cord-010092-uftc8inx 1859 16 levels level NNS cord-010092-uftc8inx 1859 17 in in IN cord-010092-uftc8inx 1859 18 blood blood NN cord-010092-uftc8inx 1859 19 donors donor NNS cord-010092-uftc8inx 1859 20 . . . cord-010092-uftc8inx 1860 1 Immune Immune NNP cord-010092-uftc8inx 1860 2 Thrombocytopenia Thrombocytopenia NNP cord-010092-uftc8inx 1860 3 ( ( -LRB- cord-010092-uftc8inx 1860 4 ITP ITP NNP cord-010092-uftc8inx 1860 5 ) ) -RRB- cord-010092-uftc8inx 1860 6 is be VBZ cord-010092-uftc8inx 1860 7 still still RB cord-010092-uftc8inx 1860 8 diagnosed diagnose VBN cord-010092-uftc8inx 1860 9 by by IN cord-010092-uftc8inx 1860 10 exclusion exclusion NN cord-010092-uftc8inx 1860 11 of of IN cord-010092-uftc8inx 1860 12 other other JJ cord-010092-uftc8inx 1860 13 causes cause NNS cord-010092-uftc8inx 1860 14 for for IN cord-010092-uftc8inx 1860 15 thrombocytopenia thrombocytopenia NN cord-010092-uftc8inx 1860 16 . . . cord-010092-uftc8inx 1861 1 Sensitive sensitive JJ cord-010092-uftc8inx 1861 2 and and CC cord-010092-uftc8inx 1861 3 specific specific JJ cord-010092-uftc8inx 1861 4 detection detection NN cord-010092-uftc8inx 1861 5 of of IN cord-010092-uftc8inx 1861 6 platelet platelet NN cord-010092-uftc8inx 1861 7 autoantibodies autoantibody NNS cord-010092-uftc8inx 1861 8 may may MD cord-010092-uftc8inx 1861 9 support support VB cord-010092-uftc8inx 1861 10 the the DT cord-010092-uftc8inx 1861 11 clinical clinical JJ cord-010092-uftc8inx 1861 12 diagnosis diagnosis NN cord-010092-uftc8inx 1861 13 and and CC cord-010092-uftc8inx 1861 14 prevent prevent VB cord-010092-uftc8inx 1861 15 misdiagnosis misdiagnosis NN cord-010092-uftc8inx 1861 16 of of IN cord-010092-uftc8inx 1861 17 ITP ITP NNP cord-010092-uftc8inx 1861 18 . . . cord-010092-uftc8inx 1862 1 For for IN cord-010092-uftc8inx 1862 2 example example NN cord-010092-uftc8inx 1862 3 , , , cord-010092-uftc8inx 1862 4 the the DT cord-010092-uftc8inx 1862 5 direct direct JJ cord-010092-uftc8inx 1862 6 monoclonal monoclonal JJ cord-010092-uftc8inx 1862 7 antibody antibody NN cord-010092-uftc8inx 1862 8 immobilization immobilization NN cord-010092-uftc8inx 1862 9 of of IN cord-010092-uftc8inx 1862 10 platelet platelet NN cord-010092-uftc8inx 1862 11 antigens antigen NNS cord-010092-uftc8inx 1862 12 ( ( -LRB- cord-010092-uftc8inx 1862 13 MAIPA MAIPA NNP cord-010092-uftc8inx 1862 14 ) ) -RRB- cord-010092-uftc8inx 1862 15 assay assay NN cord-010092-uftc8inx 1862 16 , , , cord-010092-uftc8inx 1862 17 performed perform VBN cord-010092-uftc8inx 1862 18 with with IN cord-010092-uftc8inx 1862 19 in in IN cord-010092-uftc8inx 1862 20 vivo vivo NN cord-010092-uftc8inx 1862 21 sensitized sensitize VBN cord-010092-uftc8inx 1862 22 patient patient NN cord-010092-uftc8inx 1862 23 platelets platelet NNS cord-010092-uftc8inx 1862 24 , , , cord-010092-uftc8inx 1862 25 offers offer VBZ cord-010092-uftc8inx 1862 26 platelet platelet NN cord-010092-uftc8inx 1862 27 glycoprotein glycoprotein NN cord-010092-uftc8inx 1862 28 specific specific JJ cord-010092-uftc8inx 1862 29 autoantibody autoantibody NN cord-010092-uftc8inx 1862 30 detection detection NN cord-010092-uftc8inx 1862 31 with with IN cord-010092-uftc8inx 1862 32 high high JJ cord-010092-uftc8inx 1862 33 accuracy accuracy NN cord-010092-uftc8inx 1862 34 . . . cord-010092-uftc8inx 1863 1 A a DT cord-010092-uftc8inx 1863 2 drawback drawback NN cord-010092-uftc8inx 1863 3 is be VBZ cord-010092-uftc8inx 1863 4 that that DT cord-010092-uftc8inx 1863 5 low low JJ cord-010092-uftc8inx 1863 6 platelet platelet NN cord-010092-uftc8inx 1863 7 counts count VBZ cord-010092-uftc8inx 1863 8 demand demand VBP cord-010092-uftc8inx 1863 9 a a DT cord-010092-uftc8inx 1863 10 large large JJ cord-010092-uftc8inx 1863 11 blood blood NN cord-010092-uftc8inx 1863 12 sample sample NN cord-010092-uftc8inx 1863 13 to to TO cord-010092-uftc8inx 1863 14 have have VB cord-010092-uftc8inx 1863 15 sufficient sufficient JJ cord-010092-uftc8inx 1863 16 patient patient NN cord-010092-uftc8inx 1863 17 platelets platelet NNS cord-010092-uftc8inx 1863 18 available available JJ cord-010092-uftc8inx 1863 19 for for IN cord-010092-uftc8inx 1863 20 analysis analysis NN cord-010092-uftc8inx 1863 21 . . . cord-010092-uftc8inx 1864 1 Circulating circulate VBG cord-010092-uftc8inx 1864 2 platelet platelet NN cord-010092-uftc8inx 1864 3 autoantibodies autoantibody NNS cord-010092-uftc8inx 1864 4 are be VBP cord-010092-uftc8inx 1864 5 more more RBR cord-010092-uftc8inx 1864 6 difficult difficult JJ cord-010092-uftc8inx 1864 7 to to TO cord-010092-uftc8inx 1864 8 detect detect VB cord-010092-uftc8inx 1864 9 by by IN cord-010092-uftc8inx 1864 10 MAIPA MAIPA NNP cord-010092-uftc8inx 1864 11 ; ; : cord-010092-uftc8inx 1864 12 and and CC cord-010092-uftc8inx 1864 13 may may MD cord-010092-uftc8inx 1864 14 demand demand VB cord-010092-uftc8inx 1864 15 more more RBR cord-010092-uftc8inx 1864 16 sensitive sensitive JJ cord-010092-uftc8inx 1864 17 detection detection NN cord-010092-uftc8inx 1864 18 platforms platform NNS cord-010092-uftc8inx 1864 19 , , , cord-010092-uftc8inx 1864 20 such such JJ cord-010092-uftc8inx 1864 21 as as IN cord-010092-uftc8inx 1864 22 those those DT cord-010092-uftc8inx 1864 23 using use VBG cord-010092-uftc8inx 1864 24 surface surface NN cord-010092-uftc8inx 1864 25 plasmon plasmon JJ cord-010092-uftc8inx 1864 26 resonance resonance NN cord-010092-uftc8inx 1864 27 . . . cord-010092-uftc8inx 1865 1 In in IN cord-010092-uftc8inx 1865 2 general general JJ cord-010092-uftc8inx 1865 3 , , , cord-010092-uftc8inx 1865 4 the the DT cord-010092-uftc8inx 1865 5 presence presence NN cord-010092-uftc8inx 1865 6 of of IN cord-010092-uftc8inx 1865 7 anti anti JJ cord-010092-uftc8inx 1865 8 - - JJ cord-010092-uftc8inx 1865 9 GPIIb GPIIb NNS cord-010092-uftc8inx 1865 10 / / SYM cord-010092-uftc8inx 1865 11 IIIa iiia NN cord-010092-uftc8inx 1865 12 , , , cord-010092-uftc8inx 1865 13 anti anti JJ cord-010092-uftc8inx 1865 14 - - JJ cord-010092-uftc8inx 1865 15 GPIb gpib JJ cord-010092-uftc8inx 1865 16 / / SYM cord-010092-uftc8inx 1865 17 IX IX NNP cord-010092-uftc8inx 1865 18 and and CC cord-010092-uftc8inx 1865 19 anti anti JJ cord-010092-uftc8inx 1865 20 - - JJ cord-010092-uftc8inx 1865 21 GPV gpv JJ cord-010092-uftc8inx 1865 22 platelet platelet NN cord-010092-uftc8inx 1865 23 autoantibodies autoantibody NNS cord-010092-uftc8inx 1865 24 is be VBZ cord-010092-uftc8inx 1865 25 investigated investigate VBN cord-010092-uftc8inx 1865 26 . . . cord-010092-uftc8inx 1866 1 All all PDT cord-010092-uftc8inx 1866 2 these these DT cord-010092-uftc8inx 1866 3 antibody antibody NN cord-010092-uftc8inx 1866 4 specificities specificity NNS cord-010092-uftc8inx 1866 5 have have VBP cord-010092-uftc8inx 1866 6 been be VBN cord-010092-uftc8inx 1866 7 found find VBN cord-010092-uftc8inx 1866 8 in in IN cord-010092-uftc8inx 1866 9 patients patient NNS cord-010092-uftc8inx 1866 10 with with IN cord-010092-uftc8inx 1866 11 ITP ITP NNP cord-010092-uftc8inx 1866 12 . . . cord-010092-uftc8inx 1867 1 In in IN cord-010092-uftc8inx 1867 2 ITP ITP NNP cord-010092-uftc8inx 1867 3 , , , cord-010092-uftc8inx 1867 4 platelet platelet NN cord-010092-uftc8inx 1867 5 autoantibody autoantibody NN cord-010092-uftc8inx 1867 6 - - HYPH cord-010092-uftc8inx 1867 7 mediated mediate VBN cord-010092-uftc8inx 1867 8 destruction destruction NN cord-010092-uftc8inx 1867 9 via via IN cord-010092-uftc8inx 1867 10 the the DT cord-010092-uftc8inx 1867 11 spleen spleen NN cord-010092-uftc8inx 1867 12 has have VBZ cord-010092-uftc8inx 1867 13 been be VBN cord-010092-uftc8inx 1867 14 proposed propose VBN cord-010092-uftc8inx 1867 15 ; ; : cord-010092-uftc8inx 1867 16 but but CC cord-010092-uftc8inx 1867 17 also also RB cord-010092-uftc8inx 1867 18 other other JJ cord-010092-uftc8inx 1867 19 mechanisms mechanism NNS cord-010092-uftc8inx 1867 20 leading lead VBG cord-010092-uftc8inx 1867 21 to to IN cord-010092-uftc8inx 1867 22 low low JJ cord-010092-uftc8inx 1867 23 platelet platelet NN cord-010092-uftc8inx 1867 24 counts count NNS cord-010092-uftc8inx 1867 25 in in IN cord-010092-uftc8inx 1867 26 ITP ITP NNP cord-010092-uftc8inx 1867 27 may may MD cord-010092-uftc8inx 1867 28 play play VB cord-010092-uftc8inx 1867 29 a a DT cord-010092-uftc8inx 1867 30 role role NN cord-010092-uftc8inx 1867 31 . . . cord-010092-uftc8inx 1868 1 Inhibition inhibition NN cord-010092-uftc8inx 1868 2 of of IN cord-010092-uftc8inx 1868 3 megakaryocytopoiesis megakaryocytopoiesis NNP cord-010092-uftc8inx 1868 4 by by IN cord-010092-uftc8inx 1868 5 autoantibodies autoantibody NNS cord-010092-uftc8inx 1868 6 or or CC cord-010092-uftc8inx 1868 7 by by IN cord-010092-uftc8inx 1868 8 T T NNP cord-010092-uftc8inx 1868 9 cells cell NNS cord-010092-uftc8inx 1868 10 has have VBZ cord-010092-uftc8inx 1868 11 been be VBN cord-010092-uftc8inx 1868 12 suggested suggest VBN cord-010092-uftc8inx 1868 13 . . . cord-010092-uftc8inx 1869 1 In in IN cord-010092-uftc8inx 1869 2 mice mouse NNS cord-010092-uftc8inx 1869 3 , , , cord-010092-uftc8inx 1869 4 GPIb GPIb NNS cord-010092-uftc8inx 1869 5 - - HYPH cord-010092-uftc8inx 1869 6 directed direct VBN cord-010092-uftc8inx 1869 7 antibodies antibody NNS cord-010092-uftc8inx 1869 8 induce induce VBP cord-010092-uftc8inx 1869 9 loss loss NN cord-010092-uftc8inx 1869 10 of of IN cord-010092-uftc8inx 1869 11 platelet platelet NN cord-010092-uftc8inx 1869 12 - - HYPH cord-010092-uftc8inx 1869 13 sugar sugar NN cord-010092-uftc8inx 1869 14 epitopes epitope NNS cord-010092-uftc8inx 1869 15 , , , cord-010092-uftc8inx 1869 16 inducing induce VBG cord-010092-uftc8inx 1869 17 hepatocyte hepatocyte NN cord-010092-uftc8inx 1869 18 - - HYPH cord-010092-uftc8inx 1869 19 medicated medicate VBN cord-010092-uftc8inx 1869 20 platelet platelet NN cord-010092-uftc8inx 1869 21 destruction destruction NN cord-010092-uftc8inx 1869 22 . . . cord-010092-uftc8inx 1870 1 Platelet platelet NN cord-010092-uftc8inx 1870 2 autoantibodies autoantibody NNS cord-010092-uftc8inx 1870 3 can can MD cord-010092-uftc8inx 1870 4 cause cause VB cord-010092-uftc8inx 1870 5 complement complement JJ cord-010092-uftc8inx 1870 6 activation activation NN cord-010092-uftc8inx 1870 7 , , , cord-010092-uftc8inx 1870 8 which which WDT cord-010092-uftc8inx 1870 9 may may MD cord-010092-uftc8inx 1870 10 contribute contribute VB cord-010092-uftc8inx 1870 11 to to IN cord-010092-uftc8inx 1870 12 platelet platelet NN cord-010092-uftc8inx 1870 13 autoantibodymediated autoantibodymediate VBN cord-010092-uftc8inx 1870 14 destruction destruction NN cord-010092-uftc8inx 1870 15 . . . cord-010092-uftc8inx 1871 1 Interestingly interestingly RB cord-010092-uftc8inx 1871 2 , , , cord-010092-uftc8inx 1871 3 we -PRON- PRP cord-010092-uftc8inx 1871 4 recently recently RB cord-010092-uftc8inx 1871 5 found find VBD cord-010092-uftc8inx 1871 6 that that IN cord-010092-uftc8inx 1871 7 lack lack NN cord-010092-uftc8inx 1871 8 of of IN cord-010092-uftc8inx 1871 9 detectable detectable JJ cord-010092-uftc8inx 1871 10 platelet platelet NN cord-010092-uftc8inx 1871 11 autoantibodies autoantibody NNS cord-010092-uftc8inx 1871 12 is be VBZ cord-010092-uftc8inx 1871 13 correlated correlate VBN cord-010092-uftc8inx 1871 14 with with IN cord-010092-uftc8inx 1871 15 non non JJ cord-010092-uftc8inx 1871 16 - - JJ cord-010092-uftc8inx 1871 17 responsiveness responsiveness NN cord-010092-uftc8inx 1871 18 to to IN cord-010092-uftc8inx 1871 19 rituximab rituximab NN cord-010092-uftc8inx 1871 20 ( ( -LRB- cord-010092-uftc8inx 1871 21 CD20 CD20 NNP cord-010092-uftc8inx 1871 22 MoAb MoAb NNP cord-010092-uftc8inx 1871 23 ) ) -RRB- cord-010092-uftc8inx 1871 24 treatment treatment NN cord-010092-uftc8inx 1871 25 in in IN cord-010092-uftc8inx 1871 26 ITP ITP NNP cord-010092-uftc8inx 1871 27 patients patient NNS cord-010092-uftc8inx 1871 28 . . . cord-010092-uftc8inx 1872 1 In in IN cord-010092-uftc8inx 1872 2 children child NNS cord-010092-uftc8inx 1872 3 with with IN cord-010092-uftc8inx 1872 4 newly newly RB cord-010092-uftc8inx 1872 5 diagnosed diagnose VBN cord-010092-uftc8inx 1872 6 and and CC cord-010092-uftc8inx 1872 7 often often RB cord-010092-uftc8inx 1872 8 transient transient JJ cord-010092-uftc8inx 1872 9 ITP ITP NNP cord-010092-uftc8inx 1872 10 , , , cord-010092-uftc8inx 1872 11 platelet platelet NN cord-010092-uftc8inx 1872 12 autoantibodies autoantibody NNS cord-010092-uftc8inx 1872 13 of of IN cord-010092-uftc8inx 1872 14 IgG IgG NNP cord-010092-uftc8inx 1872 15 class class NN cord-010092-uftc8inx 1872 16 or or CC cord-010092-uftc8inx 1872 17 not not RB cord-010092-uftc8inx 1872 18 often often RB cord-010092-uftc8inx 1872 19 found find VBN cord-010092-uftc8inx 1872 20 , , , cord-010092-uftc8inx 1872 21 but but CC cord-010092-uftc8inx 1872 22 of of IN cord-010092-uftc8inx 1872 23 IgM IgM NNP cord-010092-uftc8inx 1872 24 class class NNP cord-010092-uftc8inx 1872 25 are be VBP cord-010092-uftc8inx 1872 26 present present JJ cord-010092-uftc8inx 1872 27 for for IN cord-010092-uftc8inx 1872 28 short short JJ cord-010092-uftc8inx 1872 29 duration duration NN cord-010092-uftc8inx 1872 30 . . . cord-010092-uftc8inx 1873 1 In in IN cord-010092-uftc8inx 1873 2 conclusion conclusion NN cord-010092-uftc8inx 1873 3 , , , cord-010092-uftc8inx 1873 4 testing test VBG cord-010092-uftc8inx 1873 5 for for IN cord-010092-uftc8inx 1873 6 platelet platelet NN cord-010092-uftc8inx 1873 7 autoantibody autoantibody NN cord-010092-uftc8inx 1873 8 characteristics characteristic NNS cord-010092-uftc8inx 1873 9 and and CC cord-010092-uftc8inx 1873 10 their -PRON- PRP$ cord-010092-uftc8inx 1873 11 pathologic pathologic JJ cord-010092-uftc8inx 1873 12 effect effect NN cord-010092-uftc8inx 1873 13 may may MD cord-010092-uftc8inx 1873 14 be be VB cord-010092-uftc8inx 1873 15 helpful helpful JJ cord-010092-uftc8inx 1873 16 in in IN cord-010092-uftc8inx 1873 17 establishing establish VBG cord-010092-uftc8inx 1873 18 the the DT cord-010092-uftc8inx 1873 19 diagnosis diagnosis NN cord-010092-uftc8inx 1873 20 of of IN cord-010092-uftc8inx 1873 21 ITP ITP NNP cord-010092-uftc8inx 1873 22 and and CC cord-010092-uftc8inx 1873 23 in in IN cord-010092-uftc8inx 1873 24 choosing choose VBG cord-010092-uftc8inx 1873 25 the the DT cord-010092-uftc8inx 1873 26 best good JJS cord-010092-uftc8inx 1873 27 individualized individualized JJ cord-010092-uftc8inx 1873 28 therapy therapy NN cord-010092-uftc8inx 1873 29 for for IN cord-010092-uftc8inx 1873 30 ITP ITP NNP cord-010092-uftc8inx 1873 31 patients patient NNS cord-010092-uftc8inx 1873 32 . . . cord-010092-uftc8inx 1874 1 4A 4a LS cord-010092-uftc8inx 1874 2 - - : cord-010092-uftc8inx 1874 3 S16 S16 NNP cord-010092-uftc8inx 1874 4 - - HYPH cord-010092-uftc8inx 1874 5 02 02 CD cord-010092-uftc8inx 1875 1 THROMBOPOIETIN THROMBOPOIETIN NNP cord-010092-uftc8inx 1875 2 RECEPTOR receptor NN cord-010092-uftc8inx 1875 3 AGONIST AGONIST NNP cord-010092-uftc8inx 1876 1 ( ( -LRB- cord-010092-uftc8inx 1876 2 TPO TPO NNP cord-010092-uftc8inx 1876 3 - - HYPH cord-010092-uftc8inx 1876 4 RA RA NNP cord-010092-uftc8inx 1876 5 ) ) -RRB- cord-010092-uftc8inx 1876 6 _SP cord-010092-uftc8inx 1877 1 TREATMENT treatment NN cord-010092-uftc8inx 1877 2 RAISES raise VBZ cord-010092-uftc8inx 1877 3 PLATELET platelet NN cord-010092-uftc8inx 1877 4 COUNTS count VBZ cord-010092-uftc8inx 1877 5 AND and CC cord-010092-uftc8inx 1877 6 INDUCES induce VBZ cord-010092-uftc8inx 1877 7 _SP cord-010092-uftc8inx 1877 8 IMMUNOMODULATION IMMUNOMODULATION NNP cord-010092-uftc8inx 1877 9 IN in IN cord-010092-uftc8inx 1877 10 IMMUNE immune JJ cord-010092-uftc8inx 1877 11 THROMBOCYTOPENIA THROMBOCYTOPENIA NNP cord-010092-uftc8inx 1877 12 _SP cord-010092-uftc8inx 1878 1 ( ( -LRB- cord-010092-uftc8inx 1878 2 ITP ITP NNP cord-010092-uftc8inx 1878 3 ) ) -RRB- cord-010092-uftc8inx 1878 4 JW JW NNP cord-010092-uftc8inx 1878 5 Semple Semple NNP cord-010092-uftc8inx 1878 6 1 1 CD cord-010092-uftc8inx 1878 7 , , , cord-010092-uftc8inx 1878 8 R R NNP cord-010092-uftc8inx 1878 9 Aslam Aslam NNP cord-010092-uftc8inx 1878 10 2 2 CD cord-010092-uftc8inx 1878 11 , , , cord-010092-uftc8inx 1878 12 E E NNP cord-010092-uftc8inx 1878 13 Speck Speck NNP cord-010092-uftc8inx 1878 14 2 2 CD cord-010092-uftc8inx 1878 15 , , , cord-010092-uftc8inx 1878 16 J J NNP cord-010092-uftc8inx 1878 17 Rebetz Rebetz NNP cord-010092-uftc8inx 1878 18 1 1 CD cord-010092-uftc8inx 1878 19 and and CC cord-010092-uftc8inx 1878 20 R R NNP cord-010092-uftc8inx 1878 21 Kapur Kapur NNP cord-010092-uftc8inx 1879 1 1 1 CD cord-010092-uftc8inx 1879 2 1 1 CD cord-010092-uftc8inx 1879 3 Lund Lund NNP cord-010092-uftc8inx 1879 4 University University NNP cord-010092-uftc8inx 1879 5 , , , cord-010092-uftc8inx 1879 6 Lund Lund NNP cord-010092-uftc8inx 1879 7 , , , cord-010092-uftc8inx 1879 8 Sweden Sweden NNP cord-010092-uftc8inx 1879 9 2 2 CD cord-010092-uftc8inx 1879 10 St. St. NNP cord-010092-uftc8inx 1879 11 Michael Michael NNP cord-010092-uftc8inx 1879 12 's 's POS cord-010092-uftc8inx 1879 13 Hospital Hospital NNP cord-010092-uftc8inx 1879 14 , , , cord-010092-uftc8inx 1879 15 Toronto Toronto NNP cord-010092-uftc8inx 1879 16 , , , cord-010092-uftc8inx 1879 17 Canada Canada NNP cord-010092-uftc8inx 1879 18 Background Background NNP cord-010092-uftc8inx 1880 1 : : : cord-010092-uftc8inx 1880 2 ITP ITP NNP cord-010092-uftc8inx 1880 3 is be VBZ cord-010092-uftc8inx 1880 4 an an DT cord-010092-uftc8inx 1880 5 autoimmune autoimmune JJ cord-010092-uftc8inx 1880 6 bleeding bleed VBG cord-010092-uftc8inx 1880 7 disorder disorder NN cord-010092-uftc8inx 1880 8 in in IN cord-010092-uftc8inx 1880 9 which which WDT cord-010092-uftc8inx 1880 10 autoantibodies autoantibody NNS cord-010092-uftc8inx 1880 11 and/ and/ NNP cord-010092-uftc8inx 1880 12 or or CC cord-010092-uftc8inx 1880 13 autoreactive autoreactive JJ cord-010092-uftc8inx 1880 14 T t NN cord-010092-uftc8inx 1880 15 cells cell NNS cord-010092-uftc8inx 1880 16 target target VBP cord-010092-uftc8inx 1880 17 the the DT cord-010092-uftc8inx 1880 18 destruction destruction NN cord-010092-uftc8inx 1880 19 of of IN cord-010092-uftc8inx 1880 20 platelets platelet NNS cord-010092-uftc8inx 1880 21 and and CC cord-010092-uftc8inx 1880 22 megakaryocytes megakaryocyte NNS cord-010092-uftc8inx 1880 23 in in IN cord-010092-uftc8inx 1880 24 the the DT cord-010092-uftc8inx 1880 25 spleen spleen NN cord-010092-uftc8inx 1880 26 and and CC cord-010092-uftc8inx 1880 27 bone bone NN cord-010092-uftc8inx 1880 28 marrow marrow NN cord-010092-uftc8inx 1880 29 . . . cord-010092-uftc8inx 1881 1 Several several JJ cord-010092-uftc8inx 1881 2 therapeutic therapeutic JJ cord-010092-uftc8inx 1881 3 options option NNS cord-010092-uftc8inx 1882 1 e.g. e.g. IN cord-010092-uftc8inx 1882 2 corticosteroids corticosteroid NNS cord-010092-uftc8inx 1882 3 , , , cord-010092-uftc8inx 1882 4 intravenous intravenous JJ cord-010092-uftc8inx 1882 5 immunoglobulins immunoglobulin NNS cord-010092-uftc8inx 1882 6 ( ( -LRB- cord-010092-uftc8inx 1882 7 IVIg ivig ADD cord-010092-uftc8inx 1882 8 ) ) -RRB- cord-010092-uftc8inx 1882 9 , , , cord-010092-uftc8inx 1882 10 Rituximab Rituximab NNP cord-010092-uftc8inx 1882 11 and and CC cord-010092-uftc8inx 1882 12 splenectomy splenectomy NN cord-010092-uftc8inx 1882 13 are be VBP cord-010092-uftc8inx 1882 14 available available JJ cord-010092-uftc8inx 1882 15 for for IN cord-010092-uftc8inx 1882 16 patients patient NNS cord-010092-uftc8inx 1882 17 but but CC cord-010092-uftc8inx 1882 18 inadequate inadequate JJ cord-010092-uftc8inx 1882 19 efficacy efficacy NN cord-010092-uftc8inx 1882 20 , , , cord-010092-uftc8inx 1882 21 side side NN cord-010092-uftc8inx 1882 22 effects effect NNS cord-010092-uftc8inx 1882 23 and/or and/or CC cord-010092-uftc8inx 1882 24 expense expense NN cord-010092-uftc8inx 1882 25 can can MD cord-010092-uftc8inx 1882 26 make make VB cord-010092-uftc8inx 1882 27 them -PRON- PRP cord-010092-uftc8inx 1882 28 undesirable undesirable JJ cord-010092-uftc8inx 1882 29 . . . cord-010092-uftc8inx 1883 1 For for IN cord-010092-uftc8inx 1883 2 the the DT cord-010092-uftc8inx 1883 3 last last JJ cord-010092-uftc8inx 1883 4 10 10 CD cord-010092-uftc8inx 1883 5 years year NNS cord-010092-uftc8inx 1883 6 , , , cord-010092-uftc8inx 1883 7 TPO TPO NNP cord-010092-uftc8inx 1883 8 - - HYPH cord-010092-uftc8inx 1883 9 RA RA NNP cord-010092-uftc8inx 1883 10 e.g. e.g. RB cord-010092-uftc8inx 1883 11 Romiplostim Romiplostim NNP cord-010092-uftc8inx 1883 12 and and CC cord-010092-uftc8inx 1883 13 Eltrombopag Eltrombopag NNP cord-010092-uftc8inx 1883 14 have have VBP cord-010092-uftc8inx 1883 15 made make VBN cord-010092-uftc8inx 1883 16 a a DT cord-010092-uftc8inx 1883 17 substantial substantial JJ cord-010092-uftc8inx 1883 18 contribution contribution NN cord-010092-uftc8inx 1883 19 to to IN cord-010092-uftc8inx 1883 20 the the DT cord-010092-uftc8inx 1883 21 treatment treatment NN cord-010092-uftc8inx 1883 22 of of IN cord-010092-uftc8inx 1883 23 ITP ITP NNP cord-010092-uftc8inx 1883 24 patient patient NN cord-010092-uftc8inx 1883 25 's 's POS cord-010092-uftc8inx 1883 26 refractory refractory JJ cord-010092-uftc8inx 1883 27 to to IN cord-010092-uftc8inx 1883 28 first first JJ cord-010092-uftc8inx 1883 29 - - HYPH cord-010092-uftc8inx 1883 30 line line NN cord-010092-uftc8inx 1883 31 treatments treatment NNS cord-010092-uftc8inx 1883 32 . . . cord-010092-uftc8inx 1884 1 Of of IN cord-010092-uftc8inx 1884 2 interest interest NN cord-010092-uftc8inx 1884 3 , , , cord-010092-uftc8inx 1884 4 approximately approximately RB cord-010092-uftc8inx 1884 5 30 30 CD cord-010092-uftc8inx 1884 6 % % NN cord-010092-uftc8inx 1884 7 of of IN cord-010092-uftc8inx 1884 8 patients patient NNS cord-010092-uftc8inx 1884 9 that that WDT cord-010092-uftc8inx 1884 10 are be VBP cord-010092-uftc8inx 1884 11 tapered taper VBN cord-010092-uftc8inx 1884 12 from from IN cord-010092-uftc8inx 1884 13 TPO TPO NNP cord-010092-uftc8inx 1884 14 - - HYPH cord-010092-uftc8inx 1884 15 RA RA NNP cord-010092-uftc8inx 1884 16 therapy therapy NN cord-010092-uftc8inx 1884 17 show show VBP cord-010092-uftc8inx 1884 18 a a DT cord-010092-uftc8inx 1884 19 sustained sustained JJ cord-010092-uftc8inx 1884 20 response response NN cord-010092-uftc8inx 1884 21 ( ( -LRB- cord-010092-uftc8inx 1884 22 e.g. e.g. RB cord-010092-uftc8inx 1884 23 a a DT cord-010092-uftc8inx 1884 24 stable stable JJ cord-010092-uftc8inx 1884 25 higher high JJR cord-010092-uftc8inx 1884 26 platelet platelet NN cord-010092-uftc8inx 1884 27 count count NN cord-010092-uftc8inx 1884 28 than than IN cord-010092-uftc8inx 1884 29 before before IN cord-010092-uftc8inx 1884 30 treatment treatment NN cord-010092-uftc8inx 1884 31 ) ) -RRB- cord-010092-uftc8inx 1884 32 . . . cord-010092-uftc8inx 1885 1 The the DT cord-010092-uftc8inx 1885 2 mechanism mechanism NN cord-010092-uftc8inx 1885 3 of of IN cord-010092-uftc8inx 1885 4 how how WRB cord-010092-uftc8inx 1885 5 TPO TPO NNP cord-010092-uftc8inx 1885 6 - - HYPH cord-010092-uftc8inx 1885 7 RA RA NNP cord-010092-uftc8inx 1885 8 induce induce VB cord-010092-uftc8inx 1885 9 these these DT cord-010092-uftc8inx 1885 10 sustained sustained JJ cord-010092-uftc8inx 1885 11 responses response NNS cord-010092-uftc8inx 1885 12 is be VBZ cord-010092-uftc8inx 1885 13 unknown unknown JJ cord-010092-uftc8inx 1885 14 . . . cord-010092-uftc8inx 1886 1 Aims aim VBZ cord-010092-uftc8inx 1886 2 : : : cord-010092-uftc8inx 1886 3 To to TO cord-010092-uftc8inx 1886 4 analyze analyze VB cord-010092-uftc8inx 1886 5 the the DT cord-010092-uftc8inx 1886 6 efficacy efficacy NN cord-010092-uftc8inx 1886 7 and and CC cord-010092-uftc8inx 1886 8 immunomodulatory immunomodulatory JJ cord-010092-uftc8inx 1886 9 properties property NNS cord-010092-uftc8inx 1886 10 of of IN cord-010092-uftc8inx 1886 11 a a DT cord-010092-uftc8inx 1886 12 murine murine JJ cord-010092-uftc8inx 1886 13 TPO TPO NNP cord-010092-uftc8inx 1886 14 - - HYPH cord-010092-uftc8inx 1886 15 RA RA NNP cord-010092-uftc8inx 1886 16 ( ( -LRB- cord-010092-uftc8inx 1886 17 AMP4 AMP4 NNP cord-010092-uftc8inx 1886 18 , , , cord-010092-uftc8inx 1886 19 Amgen Amgen NNP cord-010092-uftc8inx 1886 20 ) ) -RRB- cord-010092-uftc8inx 1886 21 in in IN cord-010092-uftc8inx 1886 22 a a DT cord-010092-uftc8inx 1886 23 well well RB cord-010092-uftc8inx 1886 24 - - HYPH cord-010092-uftc8inx 1886 25 established establish VBN cord-010092-uftc8inx 1886 26 murine murine JJ cord-010092-uftc8inx 1886 27 model model NN cord-010092-uftc8inx 1886 28 of of IN cord-010092-uftc8inx 1886 29 ITP ITP NNP cord-010092-uftc8inx 1886 30 that that WDT cord-010092-uftc8inx 1886 31 demonstrates demonstrate VBZ cord-010092-uftc8inx 1886 32 both both DT cord-010092-uftc8inx 1886 33 antibody antibody NN cord-010092-uftc8inx 1886 34 - - : cord-010092-uftc8inx 1886 35 and and CC cord-010092-uftc8inx 1886 36 T T NNP cord-010092-uftc8inx 1886 37 cell cell NN cord-010092-uftc8inx 1886 38 - - HYPH cord-010092-uftc8inx 1886 39 mediated mediate VBN cord-010092-uftc8inx 1886 40 thrombocytopenia thrombocytopenia NN cord-010092-uftc8inx 1886 41 ( ( -LRB- cord-010092-uftc8inx 1887 1 Chow Chow NNP cord-010092-uftc8inx 1887 2 L L NNP cord-010092-uftc8inx 1887 3 et et FW cord-010092-uftc8inx 1887 4 al al NNP cord-010092-uftc8inx 1887 5 . . . cord-010092-uftc8inx 1888 1 , , , cord-010092-uftc8inx 1888 2 Blood blood NN cord-010092-uftc8inx 1888 3 2010 2010 CD cord-010092-uftc8inx 1888 4 ) ) -RRB- cord-010092-uftc8inx 1888 5 . . . cord-010092-uftc8inx 1889 1 Methods method NNS cord-010092-uftc8inx 1889 2 : : : cord-010092-uftc8inx 1889 3 Platelet platelet NN cord-010092-uftc8inx 1889 4 glycoprotein glycoprotein NN cord-010092-uftc8inx 1889 5 ( ( -LRB- cord-010092-uftc8inx 1889 6 GP GP NNP cord-010092-uftc8inx 1889 7 ) ) -RRB- cord-010092-uftc8inx 1889 8 IIIa iiia NN cord-010092-uftc8inx 1889 9 ( ( -LRB- cord-010092-uftc8inx 1889 10 CD61 CD61 NNP cord-010092-uftc8inx 1889 11 ) ) -RRB- cord-010092-uftc8inx 1889 12 knockout knockout NN cord-010092-uftc8inx 1889 13 ( ( -LRB- cord-010092-uftc8inx 1889 14 KO KO NNP cord-010092-uftc8inx 1889 15 ) ) -RRB- cord-010092-uftc8inx 1889 16 mice mouse NNS cord-010092-uftc8inx 1889 17 were be VBD cord-010092-uftc8inx 1889 18 immunized immunize VBN cord-010092-uftc8inx 1889 19 with with IN cord-010092-uftc8inx 1889 20 CD61 CD61 NNP cord-010092-uftc8inx 1889 21 + + CC cord-010092-uftc8inx 1889 22 platelets platelet NNS cord-010092-uftc8inx 1889 23 and and CC cord-010092-uftc8inx 1889 24 ITP ITP NNP cord-010092-uftc8inx 1889 25 was be VBD cord-010092-uftc8inx 1889 26 initiated initiate VBN cord-010092-uftc8inx 1889 27 by by IN cord-010092-uftc8inx 1889 28 the the DT cord-010092-uftc8inx 1889 29 transfer transfer NN cord-010092-uftc8inx 1889 30 of of IN cord-010092-uftc8inx 1889 31 their -PRON- PRP$ cord-010092-uftc8inx 1889 32 splenocytes splenocyte NNS cord-010092-uftc8inx 1889 33 into into IN cord-010092-uftc8inx 1889 34 mice mouse NNS cord-010092-uftc8inx 1889 35 with with IN cord-010092-uftc8inx 1889 36 severe severe JJ cord-010092-uftc8inx 1889 37 combined combine VBN cord-010092-uftc8inx 1889 38 immunodeficiency immunodeficiency NN cord-010092-uftc8inx 1889 39 ( ( -LRB- cord-010092-uftc8inx 1889 40 SCID SCID NNP cord-010092-uftc8inx 1889 41 ) ) -RRB- cord-010092-uftc8inx 1889 42 . . . cord-010092-uftc8inx 1890 1 The the DT cord-010092-uftc8inx 1890 2 SCID SCID NNP cord-010092-uftc8inx 1890 3 mice mouse NNS cord-010092-uftc8inx 1890 4 were be VBD cord-010092-uftc8inx 1890 5 treated treat VBN cord-010092-uftc8inx 1890 6 with with IN cord-010092-uftc8inx 1890 7 either either CC cord-010092-uftc8inx 1890 8 placebo placebo NN cord-010092-uftc8inx 1890 9 or or CC cord-010092-uftc8inx 1890 10 TPO TPO NNP cord-010092-uftc8inx 1890 11 - - HYPH cord-010092-uftc8inx 1890 12 RA RA NNP cord-010092-uftc8inx 1890 13 weekly weekly NN cord-010092-uftc8inx 1890 14 and and CC cord-010092-uftc8inx 1890 15 platelet platelet NN cord-010092-uftc8inx 1890 16 counts count NNS cord-010092-uftc8inx 1890 17 and and CC cord-010092-uftc8inx 1890 18 serum serum NN cord-010092-uftc8inx 1890 19 anti anti JJ cord-010092-uftc8inx 1890 20 - - JJ cord-010092-uftc8inx 1890 21 platelet platelet JJ cord-010092-uftc8inx 1890 22 antibodies antibody NNS cord-010092-uftc8inx 1890 23 were be VBD cord-010092-uftc8inx 1890 24 measured measure VBN cord-010092-uftc8inx 1890 25 weekly weekly RB cord-010092-uftc8inx 1890 26 . . . cord-010092-uftc8inx 1891 1 Results result NNS cord-010092-uftc8inx 1891 2 : : : cord-010092-uftc8inx 1892 1 In in IN cord-010092-uftc8inx 1892 2 an an DT cord-010092-uftc8inx 1892 3 initial initial JJ cord-010092-uftc8inx 1892 4 pilot pilot NN cord-010092-uftc8inx 1892 5 dose dose NN cord-010092-uftc8inx 1892 6 escalation escalation NN cord-010092-uftc8inx 1892 7 study study NN cord-010092-uftc8inx 1892 8 , , , cord-010092-uftc8inx 1892 9 control control NN cord-010092-uftc8inx 1892 10 na€ na€ NNP cord-010092-uftc8inx 1892 11 ıve ıve XX cord-010092-uftc8inx 1893 1 SCID SCID NNP cord-010092-uftc8inx 1893 2 mice mouse NNS cord-010092-uftc8inx 1893 3 treated treat VBN cord-010092-uftc8inx 1893 4 with with IN cord-010092-uftc8inx 1893 5 a a DT cord-010092-uftc8inx 1893 6 single single JJ cord-010092-uftc8inx 1893 7 subcutaneous subcutaneous JJ cord-010092-uftc8inx 1893 8 bolus bolus NN cord-010092-uftc8inx 1893 9 of of IN cord-010092-uftc8inx 1893 10 different different JJ cord-010092-uftc8inx 1893 11 concentrations concentration NNS cord-010092-uftc8inx 1893 12 of of IN cord-010092-uftc8inx 1893 13 murine murine JJ cord-010092-uftc8inx 1893 14 TPO TPO NNP cord-010092-uftc8inx 1893 15 - - HYPH cord-010092-uftc8inx 1893 16 RA RA NNP cord-010092-uftc8inx 1893 17 ( ( -LRB- cord-010092-uftc8inx 1893 18 1 1 CD cord-010092-uftc8inx 1893 19 , , , cord-010092-uftc8inx 1893 20 10 10 CD cord-010092-uftc8inx 1893 21 and and CC cord-010092-uftc8inx 1893 22 20 20 CD cord-010092-uftc8inx 1893 23 ug ug NNP cord-010092-uftc8inx 1893 24 / / SYM cord-010092-uftc8inx 1893 25 kg kg NNP cord-010092-uftc8inx 1893 26 ) ) -RRB- cord-010092-uftc8inx 1893 27 had have VBD cord-010092-uftc8inx 1893 28 significantly significantly RB cord-010092-uftc8inx 1893 29 higher high JJR cord-010092-uftc8inx 1893 30 platelet platelet NN cord-010092-uftc8inx 1893 31 counts count NNS cord-010092-uftc8inx 1893 32 by by IN cord-010092-uftc8inx 1893 33 72 72 CD cord-010092-uftc8inx 1893 34 h h NN cord-010092-uftc8inx 1893 35 post post NN cord-010092-uftc8inx 1893 36 infusion infusion NN cord-010092-uftc8inx 1893 37 . . . cord-010092-uftc8inx 1894 1 In in IN cord-010092-uftc8inx 1894 2 addition addition NN cord-010092-uftc8inx 1894 3 , , , cord-010092-uftc8inx 1894 4 compared compare VBN cord-010092-uftc8inx 1894 5 with with IN cord-010092-uftc8inx 1894 6 untreated untreated JJ cord-010092-uftc8inx 1894 7 mice mouse NNS cord-010092-uftc8inx 1894 8 , , , cord-010092-uftc8inx 1894 9 bone bone NN cord-010092-uftc8inx 1894 10 marrow marrow NN cord-010092-uftc8inx 1894 11 histology histology NN cord-010092-uftc8inx 1894 12 revealed reveal VBD cord-010092-uftc8inx 1894 13 significantly significantly RB cord-010092-uftc8inx 1894 14 increased increase VBN cord-010092-uftc8inx 1894 15 numbers number NNS cord-010092-uftc8inx 1894 16 of of IN cord-010092-uftc8inx 1894 17 megakaryocytes megakaryocyte NNS cord-010092-uftc8inx 1894 18 . . . cord-010092-uftc8inx 1895 1 Maximal maximal JJ cord-010092-uftc8inx 1895 2 platelet platelet NN cord-010092-uftc8inx 1895 3 count count NN cord-010092-uftc8inx 1895 4 increases increase NNS cord-010092-uftc8inx 1895 5 were be VBD cord-010092-uftc8inx 1895 6 observed observe VBN cord-010092-uftc8inx 1895 7 with with IN cord-010092-uftc8inx 1895 8 the the DT cord-010092-uftc8inx 1895 9 highest high JJS cord-010092-uftc8inx 1895 10 TPO TPO NNP cord-010092-uftc8inx 1895 11 - - HYPH cord-010092-uftc8inx 1895 12 RA RA NNP cord-010092-uftc8inx 1895 13 dose dose NN cord-010092-uftc8inx 1895 14 and and CC cord-010092-uftc8inx 1895 15 this this DT cord-010092-uftc8inx 1895 16 dose dose NN cord-010092-uftc8inx 1895 17 was be VBD cord-010092-uftc8inx 1895 18 chosen choose VBN cord-010092-uftc8inx 1895 19 to to TO cord-010092-uftc8inx 1895 20 treat treat VB cord-010092-uftc8inx 1895 21 SCID SCID NNP cord-010092-uftc8inx 1895 22 mice mouse NNS cord-010092-uftc8inx 1895 23 suffering suffer VBG cord-010092-uftc8inx 1895 24 from from IN cord-010092-uftc8inx 1895 25 ITP ITP NNP cord-010092-uftc8inx 1895 26 . . . cord-010092-uftc8inx 1896 1 When when WRB cord-010092-uftc8inx 1896 2 SCID SCID NNP cord-010092-uftc8inx 1896 3 mice mouse NNS cord-010092-uftc8inx 1896 4 were be VBD cord-010092-uftc8inx 1896 5 treated treat VBN cord-010092-uftc8inx 1896 6 with with IN cord-010092-uftc8inx 1896 7 weekly weekly JJ cord-010092-uftc8inx 1896 8 injections injection NNS cord-010092-uftc8inx 1896 9 of of IN cord-010092-uftc8inx 1896 10 TPO TPO NNP cord-010092-uftc8inx 1896 11 - - HYPH cord-010092-uftc8inx 1896 12 RA RA NNP cord-010092-uftc8inx 1896 13 , , , cord-010092-uftc8inx 1896 14 platelet platelet NN cord-010092-uftc8inx 1896 15 counts count NNS cord-010092-uftc8inx 1896 16 began begin VBD cord-010092-uftc8inx 1896 17 to to TO cord-010092-uftc8inx 1896 18 increase increase VB cord-010092-uftc8inx 1896 19 after after IN cord-010092-uftc8inx 1896 20 2 2 CD cord-010092-uftc8inx 1896 21 weeks week NNS cord-010092-uftc8inx 1896 22 and and CC cord-010092-uftc8inx 1896 23 were be VBD cord-010092-uftc8inx 1896 24 fully fully RB cord-010092-uftc8inx 1896 25 rescued rescue VBN cord-010092-uftc8inx 1896 26 to to TO cord-010092-uftc8inx 1896 27 control control VB cord-010092-uftc8inx 1896 28 levels level NNS cord-010092-uftc8inx 1896 29 after after IN cord-010092-uftc8inx 1896 30 3 3 CD cord-010092-uftc8inx 1896 31 weeks week NNS cord-010092-uftc8inx 1896 32 post post VBP cord-010092-uftc8inx 1896 33 splenocyte splenocyte NNP cord-010092-uftc8inx 1896 34 transfer transfer NN cord-010092-uftc8inx 1896 35 . . . cord-010092-uftc8inx 1897 1 Of of IN cord-010092-uftc8inx 1897 2 interest interest NN cord-010092-uftc8inx 1897 3 , , , cord-010092-uftc8inx 1897 4 compared compare VBN cord-010092-uftc8inx 1897 5 with with IN cord-010092-uftc8inx 1897 6 non non JJ cord-010092-uftc8inx 1897 7 - - JJ cord-010092-uftc8inx 1897 8 treated treated JJ cord-010092-uftc8inx 1897 9 ITP ITP NNP cord-010092-uftc8inx 1897 10 mice mouse NNS cord-010092-uftc8inx 1897 11 , , , cord-010092-uftc8inx 1897 12 serum serum NN cord-010092-uftc8inx 1897 13 IgG IgG NNP cord-010092-uftc8inx 1897 14 anti anti JJ cord-010092-uftc8inx 1897 15 - - JJ cord-010092-uftc8inx 1897 16 platelet platelet JJ cord-010092-uftc8inx 1897 17 antibody antibody NN cord-010092-uftc8inx 1897 18 production production NN cord-010092-uftc8inx 1897 19 in in IN cord-010092-uftc8inx 1897 20 the the DT cord-010092-uftc8inx 1897 21 TPO TPO NNP cord-010092-uftc8inx 1897 22 - - HYPH cord-010092-uftc8inx 1897 23 treated treat VBN cord-010092-uftc8inx 1897 24 mice mouse NNS cord-010092-uftc8inx 1897 25 was be VBD cord-010092-uftc8inx 1897 26 significantly significantly RB cord-010092-uftc8inx 1897 27 reduced reduce VBN cord-010092-uftc8inx 1897 28 starting start VBG cord-010092-uftc8inx 1897 29 from from IN cord-010092-uftc8inx 1897 30 two two CD cord-010092-uftc8inx 1897 31 weeks week NNS cord-010092-uftc8inx 1897 32 post post NNP cord-010092-uftc8inx 1897 33 splenocyte splenocyte NNP cord-010092-uftc8inx 1897 34 infusion infusion NN cord-010092-uftc8inx 1897 35 . . . cord-010092-uftc8inx 1898 1 Summary Summary NNP cord-010092-uftc8inx 1898 2 / / SYM cord-010092-uftc8inx 1898 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 1898 4 : : : cord-010092-uftc8inx 1899 1 These these DT cord-010092-uftc8inx 1899 2 results result NNS cord-010092-uftc8inx 1899 3 suggest suggest VBP cord-010092-uftc8inx 1899 4 that that IN cord-010092-uftc8inx 1899 5 murine murine JJ cord-010092-uftc8inx 1899 6 TPO TPO NNP cord-010092-uftc8inx 1899 7 - - HYPH cord-010092-uftc8inx 1899 8 RA RA NNP cord-010092-uftc8inx 1899 9 is be VBZ cord-010092-uftc8inx 1899 10 not not RB cord-010092-uftc8inx 1899 11 only only RB cord-010092-uftc8inx 1899 12 an an DT cord-010092-uftc8inx 1899 13 efficacious efficacious JJ cord-010092-uftc8inx 1899 14 therapy therapy NN cord-010092-uftc8inx 1899 15 for for IN cord-010092-uftc8inx 1899 16 murine murine JJ cord-010092-uftc8inx 1899 17 ITP ITP NNP cord-010092-uftc8inx 1899 18 but but CC cord-010092-uftc8inx 1899 19 also also RB cord-010092-uftc8inx 1899 20 induces induce VBZ cord-010092-uftc8inx 1899 21 immunomodulation immunomodulation NN cord-010092-uftc8inx 1899 22 indicative indicative JJ cord-010092-uftc8inx 1899 23 of of IN cord-010092-uftc8inx 1899 24 immunosuppression immunosuppression NN cord-010092-uftc8inx 1899 25 . . . cord-010092-uftc8inx 1900 1 Thus thus RB cord-010092-uftc8inx 1900 2 , , , cord-010092-uftc8inx 1900 3 this this DT cord-010092-uftc8inx 1900 4 model model NN cord-010092-uftc8inx 1900 5 may may MD cord-010092-uftc8inx 1900 6 be be VB cord-010092-uftc8inx 1900 7 able able JJ cord-010092-uftc8inx 1900 8 to to TO cord-010092-uftc8inx 1900 9 elucidate elucidate VB cord-010092-uftc8inx 1900 10 the the DT cord-010092-uftc8inx 1900 11 mechanism mechanism NN cord-010092-uftc8inx 1900 12 of of IN cord-010092-uftc8inx 1900 13 how how WRB cord-010092-uftc8inx 1900 14 TPO TPO NNP cord-010092-uftc8inx 1900 15 - - HYPH cord-010092-uftc8inx 1900 16 RA RA NNP cord-010092-uftc8inx 1900 17 's 's POS cord-010092-uftc8inx 1900 18 induced induce VBN cord-010092-uftc8inx 1900 19 immunosuppression immunosuppression NN cord-010092-uftc8inx 1900 20 in in IN cord-010092-uftc8inx 1900 21 patients patient NNS cord-010092-uftc8inx 1900 22 with with IN cord-010092-uftc8inx 1900 23 ITP ITP NNP cord-010092-uftc8inx 1900 24 . . . cord-010092-uftc8inx 1901 1 Background background NN cord-010092-uftc8inx 1901 2 : : : cord-010092-uftc8inx 1902 1 Desialylation Desialylation NNP cord-010092-uftc8inx 1902 2 , , , cord-010092-uftc8inx 1902 3 the the DT cord-010092-uftc8inx 1902 4 loss loss NN cord-010092-uftc8inx 1902 5 of of IN cord-010092-uftc8inx 1902 6 sialic sialic JJ cord-010092-uftc8inx 1902 7 acid acid NN cord-010092-uftc8inx 1902 8 content content NN cord-010092-uftc8inx 1902 9 on on IN cord-010092-uftc8inx 1902 10 platelets platelet NNS cord-010092-uftc8inx 1902 11 ( ( -LRB- cord-010092-uftc8inx 1902 12 PLTs plt NNS cord-010092-uftc8inx 1902 13 ) ) -RRB- cord-010092-uftc8inx 1902 14 glycoproteins glycoprotein NNS cord-010092-uftc8inx 1902 15 ( ( -LRB- cord-010092-uftc8inx 1902 16 GPs GPs NNP cord-010092-uftc8inx 1902 17 ) ) -RRB- cord-010092-uftc8inx 1902 18 was be VBD cord-010092-uftc8inx 1902 19 recently recently RB cord-010092-uftc8inx 1902 20 identified identify VBN cord-010092-uftc8inx 1902 21 to to TO cord-010092-uftc8inx 1902 22 contribute contribute VB cord-010092-uftc8inx 1902 23 in in IN cord-010092-uftc8inx 1902 24 immune immune JJ cord-010092-uftc8inx 1902 25 thrombocytopenia thrombocytopenia NN cord-010092-uftc8inx 1902 26 ( ( -LRB- cord-010092-uftc8inx 1902 27 ITP ITP NNP cord-010092-uftc8inx 1902 28 ) ) -RRB- cord-010092-uftc8inx 1902 29 . . . cord-010092-uftc8inx 1903 1 However however RB cord-010092-uftc8inx 1903 2 , , , cord-010092-uftc8inx 1903 3 the the DT cord-010092-uftc8inx 1903 4 potential potential JJ cord-010092-uftc8inx 1903 5 impact impact NN cord-010092-uftc8inx 1903 6 of of IN cord-010092-uftc8inx 1903 7 autoantibodies autoantibody NNS cord-010092-uftc8inx 1903 8 ( ( -LRB- cord-010092-uftc8inx 1903 9 AAbs AAbs NNP cord-010092-uftc8inx 1903 10 ) ) -RRB- cord-010092-uftc8inx 1903 11 on on IN cord-010092-uftc8inx 1903 12 megakaryocyte megakaryocyte NNP cord-010092-uftc8inx 1903 13 sialylation sialylation NNP cord-010092-uftc8inx 1903 14 remains remain VBZ cord-010092-uftc8inx 1903 15 unclear unclear JJ cord-010092-uftc8inx 1903 16 . . . cord-010092-uftc8inx 1904 1 Aims aim VBZ cord-010092-uftc8inx 1904 2 : : : cord-010092-uftc8inx 1904 3 To to TO cord-010092-uftc8inx 1904 4 investigate investigate VB cord-010092-uftc8inx 1904 5 the the DT cord-010092-uftc8inx 1904 6 effect effect NN cord-010092-uftc8inx 1904 7 of of IN cord-010092-uftc8inx 1904 8 ITP ITP NNP cord-010092-uftc8inx 1904 9 AAbs AAbs NNP cord-010092-uftc8inx 1904 10 on on IN cord-010092-uftc8inx 1904 11 PLTs plt NNS cord-010092-uftc8inx 1904 12 and and CC cord-010092-uftc8inx 1904 13 megakaryocytes megakaryocytes NNP cord-010092-uftc8inx 1904 14 ( ( -LRB- cord-010092-uftc8inx 1904 15 MKs MKs NNP cord-010092-uftc8inx 1904 16 ) ) -RRB- cord-010092-uftc8inx 1904 17 sialylation sialylation NN cord-010092-uftc8inx 1904 18 and and CC cord-010092-uftc8inx 1904 19 the the DT cord-010092-uftc8inx 1904 20 subsequent subsequent JJ cord-010092-uftc8inx 1904 21 impact impact NN cord-010092-uftc8inx 1904 22 on on IN cord-010092-uftc8inx 1904 23 PLT PLT NNP cord-010092-uftc8inx 1904 24 survival survival NN cord-010092-uftc8inx 1904 25 . . . cord-010092-uftc8inx 1905 1 Methods method NNS cord-010092-uftc8inx 1905 2 : : : cord-010092-uftc8inx 1906 1 AAbs AAbs NNP cord-010092-uftc8inx 1906 2 from from IN cord-010092-uftc8inx 1906 3 well well RB cord-010092-uftc8inx 1906 4 - - HYPH cord-010092-uftc8inx 1906 5 characterised characterise VBN cord-010092-uftc8inx 1906 6 ITP ITP NNP cord-010092-uftc8inx 1906 7 patients patient NNS cord-010092-uftc8inx 1906 8 induced induce VBN cord-010092-uftc8inx 1906 9 GP gp NN cord-010092-uftc8inx 1906 10 - - HYPH cord-010092-uftc8inx 1906 11 modifications modification NNS cord-010092-uftc8inx 1906 12 were be VBD cord-010092-uftc8inx 1906 13 tested test VBN cord-010092-uftc8inx 1906 14 using use VBG cord-010092-uftc8inx 1906 15 a a DT cord-010092-uftc8inx 1906 16 lectin lectin NN cord-010092-uftc8inx 1906 17 binding bind VBG cord-010092-uftc8inx 1906 18 assay assay NN cord-010092-uftc8inx 1906 19 . . . cord-010092-uftc8inx 1907 1 After after IN cord-010092-uftc8inx 1907 2 incubation incubation NN cord-010092-uftc8inx 1907 3 of of IN cord-010092-uftc8inx 1907 4 MKs MKs NNP cord-010092-uftc8inx 1907 5 or or CC cord-010092-uftc8inx 1907 6 PLTs PLTs NNPS cord-010092-uftc8inx 1907 7 with with IN cord-010092-uftc8inx 1907 8 ITP ITP NNP cord-010092-uftc8inx 1907 9 or or CC cord-010092-uftc8inx 1907 10 control control NNP cord-010092-uftc8inx 1907 11 sera sera NNP cord-010092-uftc8inx 1907 12 , , , cord-010092-uftc8inx 1907 13 glycan glycan NN cord-010092-uftc8inx 1907 14 changes change NNS cord-010092-uftc8inx 1907 15 were be VBD cord-010092-uftc8inx 1907 16 analysed analyse VBN cord-010092-uftc8inx 1907 17 by by IN cord-010092-uftc8inx 1907 18 flow flow NN cord-010092-uftc8inx 1907 19 cytometry cytometry NN cord-010092-uftc8inx 1907 20 ( ( -LRB- cord-010092-uftc8inx 1907 21 FC FC NNP cord-010092-uftc8inx 1907 22 ) ) -RRB- cord-010092-uftc8inx 1907 23 . . . cord-010092-uftc8inx 1908 1 To to TO cord-010092-uftc8inx 1908 2 investigate investigate VB cord-010092-uftc8inx 1908 3 the the DT cord-010092-uftc8inx 1908 4 impact impact NN cord-010092-uftc8inx 1908 5 of of IN cord-010092-uftc8inx 1908 6 desialylation desialylation NN cord-010092-uftc8inx 1908 7 on on IN cord-010092-uftc8inx 1908 8 PLTs plt NNS cord-010092-uftc8inx 1908 9 life life NN cord-010092-uftc8inx 1908 10 - - HYPH cord-010092-uftc8inx 1908 11 span span NN cord-010092-uftc8inx 1908 12 , , , cord-010092-uftc8inx 1908 13 the the DT cord-010092-uftc8inx 1908 14 NOD NOD NNP cord-010092-uftc8inx 1908 15 / / SYM cord-010092-uftc8inx 1908 16 SCID SCID NNP cord-010092-uftc8inx 1908 17 mouse mouse NN cord-010092-uftc8inx 1908 18 model model NN cord-010092-uftc8inx 1908 19 was be VBD cord-010092-uftc8inx 1908 20 used use VBN cord-010092-uftc8inx 1908 21 . . . cord-010092-uftc8inx 1909 1 Results result NNS cord-010092-uftc8inx 1909 2 : : : cord-010092-uftc8inx 1910 1 112 112 CD cord-010092-uftc8inx 1910 2 ITP ITP NNP cord-010092-uftc8inx 1910 3 sera sera NNP cord-010092-uftc8inx 1910 4 were be VBD cord-010092-uftc8inx 1910 5 investigated investigate VBN cord-010092-uftc8inx 1910 6 in in IN cord-010092-uftc8inx 1910 7 this this DT cord-010092-uftc8inx 1910 8 study study NN cord-010092-uftc8inx 1910 9 . . . cord-010092-uftc8inx 1911 1 35 35 CD cord-010092-uftc8inx 1911 2 ( ( -LRB- cord-010092-uftc8inx 1911 3 31 31 CD cord-010092-uftc8inx 1911 4 % % NN cord-010092-uftc8inx 1911 5 ) ) -RRB- cord-010092-uftc8inx 1911 6 sera sera NNP cord-010092-uftc8inx 1911 7 induced induce VBD cord-010092-uftc8inx 1911 8 a a DT cord-010092-uftc8inx 1911 9 significant significant JJ cord-010092-uftc8inx 1911 10 increase increase NN cord-010092-uftc8inx 1911 11 in in IN cord-010092-uftc8inx 1911 12 RCA RCA NNP cord-010092-uftc8inx 1911 13 signal signal NN cord-010092-uftc8inx 1911 14 on on IN cord-010092-uftc8inx 1911 15 PLT PLT NNP cord-010092-uftc8inx 1911 16 surface surface NN cord-010092-uftc8inx 1911 17 compared compare VBN cord-010092-uftc8inx 1911 18 to to TO cord-010092-uftc8inx 1911 19 control control VB cord-010092-uftc8inx 1911 20 sera sera NNP cord-010092-uftc8inx 1911 21 from from IN cord-010092-uftc8inx 1911 22 healthy healthy JJ cord-010092-uftc8inx 1911 23 donors donor NNS cord-010092-uftc8inx 1911 24 ( ( -LRB- cord-010092-uftc8inx 1911 25 RCA RCA NNP cord-010092-uftc8inx 1911 26 - - HYPH cord-010092-uftc8inx 1911 27 mean mean JJ cord-010092-uftc8inx 1911 28 fold fold JJ cord-010092-uftc8inx 1911 29 increase increase NN cord-010092-uftc8inx 1911 30 ( ( -LRB- cord-010092-uftc8inx 1911 31 RCA RCA NNP cord-010092-uftc8inx 1911 32 - - HYPH cord-010092-uftc8inx 1911 33 FI FI NNP cord-010092-uftc8inx 1911 34 ) ) -RRB- cord-010092-uftc8inx 1911 35 : : : cord-010092-uftc8inx 1911 36 3.23 3.23 CD cord-010092-uftc8inx 1911 37 , , , cord-010092-uftc8inx 1911 38 range range NN cord-010092-uftc8inx 1911 39 : : : cord-010092-uftc8inx 1911 40 1.76 1.76 CD cord-010092-uftc8inx 1911 41 - - HYPH cord-010092-uftc8inx 1911 42 13.61 13.61 CD cord-010092-uftc8inx 1911 43 , , , cord-010092-uftc8inx 1911 44 P p NN cord-010092-uftc8inx 1911 45 = = SYM cord-010092-uftc8inx 1911 46 0.0001 0.0001 CD cord-010092-uftc8inx 1911 47 ) ) -RRB- cord-010092-uftc8inx 1911 48 . . . cord-010092-uftc8inx 1912 1 In in IN cord-010092-uftc8inx 1912 2 addition addition NN cord-010092-uftc8inx 1912 3 , , , cord-010092-uftc8inx 1912 4 23 23 CD cord-010092-uftc8inx 1912 5 ( ( -LRB- cord-010092-uftc8inx 1912 6 21 21 CD cord-010092-uftc8inx 1912 7 % % NN cord-010092-uftc8inx 1912 8 ) ) -RRB- cord-010092-uftc8inx 1912 9 sera sera NNP cord-010092-uftc8inx 1912 10 caused cause VBD cord-010092-uftc8inx 1912 11 higher high JJR cord-010092-uftc8inx 1912 12 ECL ECL NNP cord-010092-uftc8inx 1912 13 binding bind VBG cord-010092-uftc8inx 1912 14 to to TO cord-010092-uftc8inx 1912 15 test test VB cord-010092-uftc8inx 1912 16 PLTs plt NNS cord-010092-uftc8inx 1912 17 ( ( -LRB- cord-010092-uftc8inx 1912 18 ECL ECL NNP cord-010092-uftc8inx 1912 19 - - HYPH cord-010092-uftc8inx 1912 20 FI FI NNP cord-010092-uftc8inx 1912 21 : : : cord-010092-uftc8inx 1912 22 2.31 2.31 CD cord-010092-uftc8inx 1912 23 , , , cord-010092-uftc8inx 1912 24 range range NN cord-010092-uftc8inx 1912 25 : : : cord-010092-uftc8inx 1912 26 1.54 1.54 CD cord-010092-uftc8inx 1912 27 - - SYM cord-010092-uftc8inx 1912 28 5.7 5.7 CD cord-010092-uftc8inx 1912 29 , , , cord-010092-uftc8inx 1912 30 P p NN cord-010092-uftc8inx 1912 31 = = SYM cord-010092-uftc8inx 1912 32 0.0001 0.0001 CD cord-010092-uftc8inx 1912 33 ) ) -RRB- cord-010092-uftc8inx 1912 34 . . . cord-010092-uftc8inx 1913 1 Injection injection NN cord-010092-uftc8inx 1913 2 of of IN cord-010092-uftc8inx 1913 3 desialylating desialylate VBG cord-010092-uftc8inx 1913 4 AAbs AAbs NNP cord-010092-uftc8inx 1913 5 resulted result VBD cord-010092-uftc8inx 1913 6 in in IN cord-010092-uftc8inx 1913 7 accelerated accelerated JJ cord-010092-uftc8inx 1913 8 clearance clearance NN cord-010092-uftc8inx 1913 9 of of IN cord-010092-uftc8inx 1913 10 human human JJ cord-010092-uftc8inx 1913 11 PLTs plt NNS cord-010092-uftc8inx 1913 12 from from IN cord-010092-uftc8inx 1913 13 the the DT cord-010092-uftc8inx 1913 14 circulation circulation NN cord-010092-uftc8inx 1913 15 of of IN cord-010092-uftc8inx 1913 16 the the DT cord-010092-uftc8inx 1913 17 NOD NOD NNP cord-010092-uftc8inx 1913 18 / / SYM cord-010092-uftc8inx 1913 19 SCID SCID NNP cord-010092-uftc8inx 1913 20 mice mouse NNS cord-010092-uftc8inx 1913 21 which which WDT cord-010092-uftc8inx 1913 22 was be VBD cord-010092-uftc8inx 1913 23 significantly significantly RB cord-010092-uftc8inx 1913 24 reduced reduce VBN cord-010092-uftc8inx 1913 25 by by IN cord-010092-uftc8inx 1913 26 a a DT cord-010092-uftc8inx 1913 27 specific specific JJ cord-010092-uftc8inx 1913 28 neuraminidase neuraminidase NN cord-010092-uftc8inx 1913 29 inhibitor inhibitor NN cord-010092-uftc8inx 1913 30 that that WDT cord-010092-uftc8inx 1913 31 prevents prevent VBZ cord-010092-uftc8inx 1913 32 Background background NN cord-010092-uftc8inx 1913 33 : : : cord-010092-uftc8inx 1913 34 Autoimmune autoimmune JJ cord-010092-uftc8inx 1913 35 hemolytic hemolytic JJ cord-010092-uftc8inx 1913 36 anemia anemia NN cord-010092-uftc8inx 1913 37 ( ( -LRB- cord-010092-uftc8inx 1913 38 AIHA AIHA NNP cord-010092-uftc8inx 1913 39 ) ) -RRB- cord-010092-uftc8inx 1913 40 is be VBZ cord-010092-uftc8inx 1913 41 a a DT cord-010092-uftc8inx 1913 42 rare rare JJ cord-010092-uftc8inx 1913 43 autoimmune autoimmune JJ cord-010092-uftc8inx 1913 44 disease disease NN cord-010092-uftc8inx 1913 45 characterised characterise VBN cord-010092-uftc8inx 1913 46 by by IN cord-010092-uftc8inx 1913 47 hemolysis hemolysis NN cord-010092-uftc8inx 1913 48 associated associate VBN cord-010092-uftc8inx 1913 49 with with IN cord-010092-uftc8inx 1913 50 the the DT cord-010092-uftc8inx 1913 51 presence presence NN cord-010092-uftc8inx 1913 52 of of IN cord-010092-uftc8inx 1913 53 immunoglobulins immunoglobulin NNS cord-010092-uftc8inx 1913 54 ( ( -LRB- cord-010092-uftc8inx 1913 55 IgG IgG NNP cord-010092-uftc8inx 1913 56 , , , cord-010092-uftc8inx 1913 57 IgM IgM NNP cord-010092-uftc8inx 1913 58 , , , cord-010092-uftc8inx 1913 59 or or CC cord-010092-uftc8inx 1913 60 IgA IgA NNP cord-010092-uftc8inx 1913 61 ) ) -RRB- cord-010092-uftc8inx 1914 1 and/or and/or CC cord-010092-uftc8inx 1914 2 components component NNS cord-010092-uftc8inx 1914 3 of of IN cord-010092-uftc8inx 1914 4 complement complement JJ cord-010092-uftc8inx 1914 5 system system NN cord-010092-uftc8inx 1914 6 on on IN cord-010092-uftc8inx 1914 7 red red JJ cord-010092-uftc8inx 1914 8 blood blood NN cord-010092-uftc8inx 1914 9 cells cell NNS cord-010092-uftc8inx 1914 10 ( ( -LRB- cord-010092-uftc8inx 1914 11 RBCs rbc NNS cord-010092-uftc8inx 1914 12 ) ) -RRB- cord-010092-uftc8inx 1914 13 , , , cord-010092-uftc8inx 1914 14 which which WDT cord-010092-uftc8inx 1914 15 is be VBZ cord-010092-uftc8inx 1914 16 usually usually RB cord-010092-uftc8inx 1914 17 demonstrated demonstrate VBN cord-010092-uftc8inx 1914 18 by by IN cord-010092-uftc8inx 1914 19 a a DT cord-010092-uftc8inx 1914 20 positive positive JJ cord-010092-uftc8inx 1914 21 direct direct JJ cord-010092-uftc8inx 1914 22 antiglobulin antiglobulin NN cord-010092-uftc8inx 1914 23 test test NN cord-010092-uftc8inx 1914 24 ( ( -LRB- cord-010092-uftc8inx 1914 25 DAT DAT NNP cord-010092-uftc8inx 1914 26 ) ) -RRB- cord-010092-uftc8inx 1914 27 . . . cord-010092-uftc8inx 1915 1 Depending depend VBG cord-010092-uftc8inx 1915 2 on on IN cord-010092-uftc8inx 1915 3 the the DT cord-010092-uftc8inx 1915 4 presence presence NN cord-010092-uftc8inx 1915 5 of of IN cord-010092-uftc8inx 1915 6 an an DT cord-010092-uftc8inx 1915 7 underlying underlying JJ cord-010092-uftc8inx 1915 8 disorder disorder NN cord-010092-uftc8inx 1915 9 , , , cord-010092-uftc8inx 1915 10 AIHA AIHA NNP cord-010092-uftc8inx 1915 11 can can MD cord-010092-uftc8inx 1915 12 be be VB cord-010092-uftc8inx 1915 13 subdivided subdivide VBN cord-010092-uftc8inx 1915 14 into into IN cord-010092-uftc8inx 1915 15 primary primary JJ cord-010092-uftc8inx 1915 16 and and CC cord-010092-uftc8inx 1915 17 secondary secondary JJ cord-010092-uftc8inx 1915 18 and and CC cord-010092-uftc8inx 1915 19 , , , cord-010092-uftc8inx 1915 20 by by IN cord-010092-uftc8inx 1915 21 the the DT cord-010092-uftc8inx 1915 22 temperature temperature NN cord-010092-uftc8inx 1915 23 at at IN cord-010092-uftc8inx 1915 24 which which WDT cord-010092-uftc8inx 1915 25 autoantibodies autoantibody NNS cord-010092-uftc8inx 1915 26 bind bind VBP cord-010092-uftc8inx 1915 27 optimally optimally RB cord-010092-uftc8inx 1915 28 to to IN cord-010092-uftc8inx 1915 29 RBCs rbc NNS cord-010092-uftc8inx 1915 30 , , , cord-010092-uftc8inx 1915 31 into into IN cord-010092-uftc8inx 1915 32 warm warm JJ cord-010092-uftc8inx 1915 33 antibody antibody NN cord-010092-uftc8inx 1915 34 AIHA AIHA NNP cord-010092-uftc8inx 1915 35 ( ( -LRB- cord-010092-uftc8inx 1915 36 wAIHA waiha NN cord-010092-uftc8inx 1915 37 ) ) -RRB- cord-010092-uftc8inx 1915 38 , , , cord-010092-uftc8inx 1915 39 mixed mixed JJ cord-010092-uftc8inx 1915 40 AIHA AIHA NNP cord-010092-uftc8inx 1915 41 ( ( -LRB- cord-010092-uftc8inx 1915 42 including include VBG cord-010092-uftc8inx 1915 43 both both DT cord-010092-uftc8inx 1915 44 warm warm JJ cord-010092-uftc8inx 1915 45 IgG IgG NNP cord-010092-uftc8inx 1915 46 and and CC cord-010092-uftc8inx 1915 47 cold cold NNP cord-010092-uftc8inx 1915 48 IgM IgM NNP cord-010092-uftc8inx 1915 49 antibodies antibodies NNP cord-010092-uftc8inx 1915 50 ) ) -RRB- cord-010092-uftc8inx 1915 51 , , , cord-010092-uftc8inx 1915 52 cold cold JJ cord-010092-uftc8inx 1915 53 agglutinin agglutinin NNS cord-010092-uftc8inx 1915 54 disease disease NN cord-010092-uftc8inx 1915 55 ( ( -LRB- cord-010092-uftc8inx 1915 56 CAD CAD NNP cord-010092-uftc8inx 1915 57 ) ) -RRB- cord-010092-uftc8inx 1915 58 , , , cord-010092-uftc8inx 1915 59 Paroxysmal Paroxysmal NNP cord-010092-uftc8inx 1915 60 Cold Cold NNP cord-010092-uftc8inx 1915 61 Hemoglobinuria Hemoglobinuria NNP cord-010092-uftc8inx 1915 62 ( ( -LRB- cord-010092-uftc8inx 1915 63 PCH PCH NNP cord-010092-uftc8inx 1915 64 ) ) -RRB- cord-010092-uftc8inx 1915 65 and and CC cord-010092-uftc8inx 1915 66 DAT DAT NNP cord-010092-uftc8inx 1915 67 negative negative JJ cord-010092-uftc8inx 1915 68 AIHA AIHA NNP cord-010092-uftc8inx 1915 69 . . . cord-010092-uftc8inx 1916 1 A a DT cord-010092-uftc8inx 1916 2 frequent frequent JJ cord-010092-uftc8inx 1916 3 finding finding NN cord-010092-uftc8inx 1916 4 in in IN cord-010092-uftc8inx 1916 5 immunohematology immunohematology NN cord-010092-uftc8inx 1916 6 is be VBZ cord-010092-uftc8inx 1916 7 the the DT cord-010092-uftc8inx 1916 8 presence presence NN cord-010092-uftc8inx 1916 9 autoantibodies autoantibody NNS cord-010092-uftc8inx 1916 10 on on IN cord-010092-uftc8inx 1916 11 RBCs rbc NNS cord-010092-uftc8inx 1916 12 without without IN cord-010092-uftc8inx 1916 13 clinical clinical JJ cord-010092-uftc8inx 1916 14 symptoms symptom NNS cord-010092-uftc8inx 1916 15 of of IN cord-010092-uftc8inx 1916 16 hemolysis hemolysis NN cord-010092-uftc8inx 1916 17 that that WDT cord-010092-uftc8inx 1916 18 may may MD cord-010092-uftc8inx 1916 19 later later RB cord-010092-uftc8inx 1916 20 develop develop VB cord-010092-uftc8inx 1916 21 . . . cord-010092-uftc8inx 1917 1 Aims aim VBZ cord-010092-uftc8inx 1917 2 : : : cord-010092-uftc8inx 1918 1 The the DT cord-010092-uftc8inx 1918 2 aim aim NN cord-010092-uftc8inx 1918 3 of of IN cord-010092-uftc8inx 1918 4 this this DT cord-010092-uftc8inx 1918 5 study study NN cord-010092-uftc8inx 1918 6 was be VBD cord-010092-uftc8inx 1918 7 to to TO cord-010092-uftc8inx 1918 8 analyse analyse VB cord-010092-uftc8inx 1918 9 serologic serologic NNP cord-010092-uftc8inx 1918 10 findings finding NNS cord-010092-uftc8inx 1918 11 and and CC cord-010092-uftc8inx 1918 12 transfusion transfusion NN cord-010092-uftc8inx 1918 13 support support NN cord-010092-uftc8inx 1918 14 in in IN cord-010092-uftc8inx 1918 15 patients patient NNS cord-010092-uftc8inx 1918 16 with with IN cord-010092-uftc8inx 1918 17 AIHA AIHA NNP cord-010092-uftc8inx 1918 18 and and CC cord-010092-uftc8inx 1918 19 also also RB cord-010092-uftc8inx 1918 20 to to TO cord-010092-uftc8inx 1918 21 analyse analyse VB cord-010092-uftc8inx 1918 22 DAT DAT NNP cord-010092-uftc8inx 1918 23 positive positive JJ cord-010092-uftc8inx 1918 24 patients patient NNS cord-010092-uftc8inx 1918 25 without without IN cord-010092-uftc8inx 1918 26 clinical clinical JJ cord-010092-uftc8inx 1918 27 symptoms symptom NNS cord-010092-uftc8inx 1918 28 . . . cord-010092-uftc8inx 1919 1 Methods method NNS cord-010092-uftc8inx 1919 2 : : : cord-010092-uftc8inx 1919 3 We -PRON- PRP cord-010092-uftc8inx 1919 4 included include VBD cord-010092-uftc8inx 1919 5 data datum NNS cord-010092-uftc8inx 1919 6 for for IN cord-010092-uftc8inx 1919 7 all all DT cord-010092-uftc8inx 1919 8 adult adult NN cord-010092-uftc8inx 1919 9 patients patient NNS cord-010092-uftc8inx 1919 10 with with IN cord-010092-uftc8inx 1919 11 AIHA AIHA NNP cord-010092-uftc8inx 1919 12 and and CC cord-010092-uftc8inx 1919 13 DAT DAT NNP cord-010092-uftc8inx 1919 14 positive positive JJ cord-010092-uftc8inx 1919 15 patients patient NNS cord-010092-uftc8inx 1919 16 without without IN cord-010092-uftc8inx 1919 17 clinical clinical JJ cord-010092-uftc8inx 1919 18 symptoms symptom NNS cord-010092-uftc8inx 1920 1 diagnosed diagnose VBN cord-010092-uftc8inx 1920 2 and/or and/or CC cord-010092-uftc8inx 1920 3 treated treat VBN cord-010092-uftc8inx 1920 4 at at IN cord-010092-uftc8inx 1920 5 the the DT cord-010092-uftc8inx 1920 6 University University NNP cord-010092-uftc8inx 1920 7 Hospital Hospital NNP cord-010092-uftc8inx 1920 8 Centre Centre NNP cord-010092-uftc8inx 1920 9 ( ( -LRB- cord-010092-uftc8inx 1920 10 UHC UHC NNP cord-010092-uftc8inx 1920 11 ) ) -RRB- cord-010092-uftc8inx 1920 12 Zagreb Zagreb NNP cord-010092-uftc8inx 1920 13 , , , cord-010092-uftc8inx 1920 14 Croatia Croatia NNP cord-010092-uftc8inx 1920 15 in in IN cord-010092-uftc8inx 1920 16 the the DT cord-010092-uftc8inx 1920 17 period period NN cord-010092-uftc8inx 1920 18 between between IN cord-010092-uftc8inx 1920 19 2014 2014 CD cord-010092-uftc8inx 1920 20 and and CC cord-010092-uftc8inx 1920 21 2018 2018 CD cord-010092-uftc8inx 1920 22 . . . cord-010092-uftc8inx 1921 1 The the DT cord-010092-uftc8inx 1921 2 diagnosis diagnosis NN cord-010092-uftc8inx 1921 3 of of IN cord-010092-uftc8inx 1921 4 AIHA AIHA NNP cord-010092-uftc8inx 1921 5 was be VBD cord-010092-uftc8inx 1921 6 defined define VBN cord-010092-uftc8inx 1921 7 by by IN cord-010092-uftc8inx 1921 8 anemia anemia NN cord-010092-uftc8inx 1921 9 with with IN cord-010092-uftc8inx 1921 10 features feature NNS cord-010092-uftc8inx 1921 11 of of IN cord-010092-uftc8inx 1921 12 hemolysis hemolysis NN cord-010092-uftc8inx 1921 13 ( ( -LRB- cord-010092-uftc8inx 1921 14 elevated elevate VBN cord-010092-uftc8inx 1921 15 bilirubin bilirubin NN cord-010092-uftc8inx 1921 16 and/ and/ CD cord-010092-uftc8inx 1921 17 or or CC cord-010092-uftc8inx 1921 18 elevated elevated JJ cord-010092-uftc8inx 1921 19 lactate lactate NN cord-010092-uftc8inx 1921 20 dehydrogenase dehydrogenase NN cord-010092-uftc8inx 1921 21 and/or and/or CC cord-010092-uftc8inx 1921 22 low low JJ cord-010092-uftc8inx 1921 23 haptoglobin haptoglobin NN cord-010092-uftc8inx 1921 24 level level NN cord-010092-uftc8inx 1921 25 ) ) -RRB- cord-010092-uftc8inx 1921 26 and and CC cord-010092-uftc8inx 1921 27 a a DT cord-010092-uftc8inx 1921 28 positive positive JJ cord-010092-uftc8inx 1921 29 DAT dat NN cord-010092-uftc8inx 1921 30 . . . cord-010092-uftc8inx 1922 1 Results result NNS cord-010092-uftc8inx 1922 2 : : : cord-010092-uftc8inx 1923 1 The the DT cord-010092-uftc8inx 1923 2 data datum NNS cord-010092-uftc8inx 1923 3 from from IN cord-010092-uftc8inx 1923 4 64 64 CD cord-010092-uftc8inx 1923 5 patients patient NNS cord-010092-uftc8inx 1923 6 ( ( -LRB- cord-010092-uftc8inx 1923 7 52 52 CD cord-010092-uftc8inx 1923 8 % % NN cord-010092-uftc8inx 1923 9 women woman NNS cord-010092-uftc8inx 1923 10 ) ) -RRB- cord-010092-uftc8inx 1923 11 meeting meet VBG cord-010092-uftc8inx 1923 12 the the DT cord-010092-uftc8inx 1923 13 inclusion inclusion NN cord-010092-uftc8inx 1923 14 criteria criterion NNS cord-010092-uftc8inx 1923 15 was be VBD cord-010092-uftc8inx 1923 16 analysed analyse VBN cord-010092-uftc8inx 1923 17 . . . cord-010092-uftc8inx 1924 1 The the DT cord-010092-uftc8inx 1924 2 mean mean JJ cord-010092-uftc8inx 1924 3 age age NN cord-010092-uftc8inx 1924 4 at at IN cord-010092-uftc8inx 1924 5 the the DT cord-010092-uftc8inx 1924 6 time time NN cord-010092-uftc8inx 1924 7 of of IN cord-010092-uftc8inx 1924 8 AIHA AIHA NNP cord-010092-uftc8inx 1924 9 was be VBD cord-010092-uftc8inx 1924 10 63 63 CD cord-010092-uftc8inx 1924 11 years year NNS cord-010092-uftc8inx 1925 1 ( ( -LRB- cord-010092-uftc8inx 1925 2 range range NNP cord-010092-uftc8inx 1925 3 22 22 CD cord-010092-uftc8inx 1925 4 - - SYM cord-010092-uftc8inx 1925 5 89 89 CD cord-010092-uftc8inx 1925 6 years year NNS cord-010092-uftc8inx 1925 7 ) ) -RRB- cord-010092-uftc8inx 1925 8 . . . cord-010092-uftc8inx 1926 1 The the DT cord-010092-uftc8inx 1926 2 mean mean JJ cord-010092-uftc8inx 1926 3 Hg Hg NNP cord-010092-uftc8inx 1926 4 level level NN cord-010092-uftc8inx 1926 5 at at IN cord-010092-uftc8inx 1926 6 diagnosis diagnosis NN cord-010092-uftc8inx 1926 7 was be VBD cord-010092-uftc8inx 1926 8 68.60 68.60 CD cord-010092-uftc8inx 1926 9 g g NN cord-010092-uftc8inx 1926 10 / / SYM cord-010092-uftc8inx 1926 11 L. L. NNP cord-010092-uftc8inx 1926 12 DAT DAT NNP cord-010092-uftc8inx 1926 13 results result NNS cord-010092-uftc8inx 1926 14 were be VBD cord-010092-uftc8inx 1926 15 positive positive JJ cord-010092-uftc8inx 1926 16 mostly mostly RB cord-010092-uftc8inx 1926 17 with with IN cord-010092-uftc8inx 1926 18 IgG+C3d IgG+C3d NNP cord-010092-uftc8inx 1926 19 ( ( -LRB- cord-010092-uftc8inx 1926 20 59 59 CD cord-010092-uftc8inx 1926 21 % % NN cord-010092-uftc8inx 1926 22 ) ) -RRB- cord-010092-uftc8inx 1926 23 or or CC cord-010092-uftc8inx 1926 24 IgG IgG NNP cord-010092-uftc8inx 1926 25 ( ( -LRB- cord-010092-uftc8inx 1926 26 31 31 CD cord-010092-uftc8inx 1926 27 % % NN cord-010092-uftc8inx 1926 28 ) ) -RRB- cord-010092-uftc8inx 1926 29 . . . cord-010092-uftc8inx 1927 1 Most Most JJS cord-010092-uftc8inx 1927 2 patients patient NNS cord-010092-uftc8inx 1927 3 had have VBD cord-010092-uftc8inx 1927 4 warm warm JJ cord-010092-uftc8inx 1927 5 AIHA AIHA NNP cord-010092-uftc8inx 1927 6 ( ( -LRB- cord-010092-uftc8inx 1927 7 70 70 CD cord-010092-uftc8inx 1927 8 % % NN cord-010092-uftc8inx 1927 9 ) ) -RRB- cord-010092-uftc8inx 1927 10 . . . cord-010092-uftc8inx 1928 1 Other other JJ cord-010092-uftc8inx 1928 2 types type NNS cord-010092-uftc8inx 1928 3 of of IN cord-010092-uftc8inx 1928 4 AIHA AIHA NNP cord-010092-uftc8inx 1928 5 diagnosed diagnose VBN cord-010092-uftc8inx 1928 6 were be VBD cord-010092-uftc8inx 1928 7 mixed mix VBN cord-010092-uftc8inx 1928 8 AIHA AIHA NNP cord-010092-uftc8inx 1928 9 ( ( -LRB- cord-010092-uftc8inx 1928 10 15 15 CD cord-010092-uftc8inx 1928 11 % % NN cord-010092-uftc8inx 1928 12 ) ) -RRB- cord-010092-uftc8inx 1928 13 , , , cord-010092-uftc8inx 1928 14 CAD CAD NNP cord-010092-uftc8inx 1928 15 ( ( -LRB- cord-010092-uftc8inx 1928 16 11 11 CD cord-010092-uftc8inx 1928 17 % % NN cord-010092-uftc8inx 1928 18 ) ) -RRB- cord-010092-uftc8inx 1928 19 , , , cord-010092-uftc8inx 1928 20 PCH PCH NNP cord-010092-uftc8inx 1928 21 ( ( -LRB- cord-010092-uftc8inx 1928 22 1.5 1.5 CD cord-010092-uftc8inx 1928 23 % % NN cord-010092-uftc8inx 1928 24 ) ) -RRB- cord-010092-uftc8inx 1928 25 and and CC cord-010092-uftc8inx 1928 26 DAT DAT NNP cord-010092-uftc8inx 1928 27 negative negative JJ cord-010092-uftc8inx 1928 28 AIHA AIHA NNP cord-010092-uftc8inx 1928 29 ( ( -LRB- cord-010092-uftc8inx 1928 30 1.5 1.5 CD cord-010092-uftc8inx 1928 31 % % NN cord-010092-uftc8inx 1928 32 ) ) -RRB- cord-010092-uftc8inx 1928 33 . . . cord-010092-uftc8inx 1929 1 In in IN cord-010092-uftc8inx 1929 2 6 6 CD cord-010092-uftc8inx 1929 3 cases case NNS cord-010092-uftc8inx 1929 4 alloantibodies alloantibody NNS cord-010092-uftc8inx 1929 5 were be VBD cord-010092-uftc8inx 1929 6 detected detect VBN cord-010092-uftc8inx 1929 7 with with IN cord-010092-uftc8inx 1929 8 autoantibodies autoantibody NNS cord-010092-uftc8inx 1929 9 in in IN cord-010092-uftc8inx 1929 10 the the DT cord-010092-uftc8inx 1929 11 patient patient NN cord-010092-uftc8inx 1929 12 's 's POS cord-010092-uftc8inx 1929 13 plasma plasma NN cord-010092-uftc8inx 1929 14 . . . cord-010092-uftc8inx 1930 1 Patients patient NNS cord-010092-uftc8inx 1930 2 were be VBD cord-010092-uftc8inx 1930 3 treated treat VBN cord-010092-uftc8inx 1930 4 with with IN cord-010092-uftc8inx 1930 5 corticosteroids corticosteroid NNS cord-010092-uftc8inx 1930 6 as as IN cord-010092-uftc8inx 1930 7 1st 1st JJ cord-010092-uftc8inx 1930 8 line line NN cord-010092-uftc8inx 1930 9 therapy therapy NN cord-010092-uftc8inx 1930 10 and and CC cord-010092-uftc8inx 1930 11 some some DT cord-010092-uftc8inx 1930 12 with with IN cord-010092-uftc8inx 1930 13 intravenous intravenous JJ cord-010092-uftc8inx 1930 14 immunoglobulins immunoglobulin NNS cord-010092-uftc8inx 1930 15 ( ( -LRB- cord-010092-uftc8inx 1930 16 IvIG IvIG NNP cord-010092-uftc8inx 1930 17 ) ) -RRB- cord-010092-uftc8inx 1930 18 . . . cord-010092-uftc8inx 1931 1 In in IN cord-010092-uftc8inx 1931 2 severe severe JJ cord-010092-uftc8inx 1931 3 or or CC cord-010092-uftc8inx 1931 4 refractory refractory JJ cord-010092-uftc8inx 1931 5 patients patient NNS cord-010092-uftc8inx 1931 6 rituximab rituximab RB cord-010092-uftc8inx 1931 7 and/or and/or CC cord-010092-uftc8inx 1931 8 splenectomy splenectomy NN cord-010092-uftc8inx 1931 9 was be VBD cord-010092-uftc8inx 1931 10 applied apply VBN cord-010092-uftc8inx 1931 11 . . . cord-010092-uftc8inx 1932 1 A a DT cord-010092-uftc8inx 1932 2 total total NN cord-010092-uftc8inx 1932 3 of of IN cord-010092-uftc8inx 1932 4 80 80 CD cord-010092-uftc8inx 1932 5 % % NN cord-010092-uftc8inx 1932 6 of of IN cord-010092-uftc8inx 1932 7 patients patient NNS cord-010092-uftc8inx 1932 8 were be VBD cord-010092-uftc8inx 1932 9 transfused transfuse VBN cord-010092-uftc8inx 1932 10 at at IN cord-010092-uftc8inx 1932 11 a a DT cord-010092-uftc8inx 1932 12 mean mean JJ cord-010092-uftc8inx 1932 13 hemoglobin hemoglobin NN cord-010092-uftc8inx 1932 14 level level NN cord-010092-uftc8inx 1932 15 of of IN cord-010092-uftc8inx 1932 16 67.88 67.88 CD cord-010092-uftc8inx 1932 17 g g NN cord-010092-uftc8inx 1932 18 / / SYM cord-010092-uftc8inx 1932 19 L. L. NNP cord-010092-uftc8inx 1933 1 During during IN cord-010092-uftc8inx 1933 2 this this DT cord-010092-uftc8inx 1933 3 period period NN cord-010092-uftc8inx 1933 4 we -PRON- PRP cord-010092-uftc8inx 1933 5 detected detect VBD cord-010092-uftc8inx 1933 6 136 136 CD cord-010092-uftc8inx 1933 7 DAT DAT NNP cord-010092-uftc8inx 1933 8 positive positive JJ cord-010092-uftc8inx 1933 9 patients patient NNS cord-010092-uftc8inx 1933 10 without without IN cord-010092-uftc8inx 1933 11 clinical clinical JJ cord-010092-uftc8inx 1933 12 symptoms symptom NNS cord-010092-uftc8inx 1933 13 . . . cord-010092-uftc8inx 1934 1 Summary Summary NNP cord-010092-uftc8inx 1934 2 / / SYM cord-010092-uftc8inx 1934 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 1934 4 : : : cord-010092-uftc8inx 1935 1 Most Most JJS cord-010092-uftc8inx 1935 2 patients patient NNS cord-010092-uftc8inx 1935 3 from from IN cord-010092-uftc8inx 1935 4 our -PRON- PRP$ cord-010092-uftc8inx 1935 5 study study NN cord-010092-uftc8inx 1935 6 were be VBD cord-010092-uftc8inx 1935 7 diagnosed diagnose VBN cord-010092-uftc8inx 1935 8 with with IN cord-010092-uftc8inx 1935 9 warm warm JJ cord-010092-uftc8inx 1935 10 type type NN cord-010092-uftc8inx 1935 11 of of IN cord-010092-uftc8inx 1935 12 AIHA AIHA NNP cord-010092-uftc8inx 1935 13 , , , cord-010092-uftc8inx 1935 14 followed follow VBN cord-010092-uftc8inx 1935 15 by by IN cord-010092-uftc8inx 1935 16 mixed mixed JJ cord-010092-uftc8inx 1935 17 type type NN cord-010092-uftc8inx 1935 18 AIHA AIHA NNP cord-010092-uftc8inx 1935 19 and and CC cord-010092-uftc8inx 1935 20 CAD CAD NNP cord-010092-uftc8inx 1935 21 . . . cord-010092-uftc8inx 1936 1 On on IN cord-010092-uftc8inx 1936 2 the the DT cord-010092-uftc8inx 1936 3 other other JJ cord-010092-uftc8inx 1936 4 hand hand NN cord-010092-uftc8inx 1936 5 , , , cord-010092-uftc8inx 1936 6 PCH PCH NNP cord-010092-uftc8inx 1936 7 and and CC cord-010092-uftc8inx 1936 8 DAT DAT NNP cord-010092-uftc8inx 1936 9 negative negative JJ cord-010092-uftc8inx 1936 10 AIHA AIHA NNP cord-010092-uftc8inx 1936 11 were be VBD cord-010092-uftc8inx 1936 12 very very RB cord-010092-uftc8inx 1936 13 rare rare JJ cord-010092-uftc8inx 1936 14 , , , cord-010092-uftc8inx 1936 15 which which WDT cord-010092-uftc8inx 1936 16 is be VBZ cord-010092-uftc8inx 1936 17 in in IN cord-010092-uftc8inx 1936 18 concordance concordance NN cord-010092-uftc8inx 1936 19 with with IN cord-010092-uftc8inx 1936 20 relevant relevant JJ cord-010092-uftc8inx 1936 21 literature literature NN cord-010092-uftc8inx 1936 22 . . . cord-010092-uftc8inx 1937 1 Most Most JJS cord-010092-uftc8inx 1937 2 patients patient NNS cord-010092-uftc8inx 1937 3 were be VBD cord-010092-uftc8inx 1937 4 transfused transfuse VBN cord-010092-uftc8inx 1937 5 despite despite IN cord-010092-uftc8inx 1937 6 therapy therapy NN cord-010092-uftc8inx 1937 7 used use VBN cord-010092-uftc8inx 1937 8 , , , cord-010092-uftc8inx 1937 9 which which WDT cord-010092-uftc8inx 1937 10 is be VBZ cord-010092-uftc8inx 1937 11 not not RB cord-010092-uftc8inx 1937 12 desirable desirable JJ cord-010092-uftc8inx 1937 13 in in IN cord-010092-uftc8inx 1937 14 patients patient NNS cord-010092-uftc8inx 1937 15 with with IN cord-010092-uftc8inx 1937 16 AIHA AIHA NNP cord-010092-uftc8inx 1937 17 and and CC cord-010092-uftc8inx 1937 18 should should MD cord-010092-uftc8inx 1937 19 be be VB cord-010092-uftc8inx 1937 20 better well RBR cord-010092-uftc8inx 1937 21 controlled control VBN cord-010092-uftc8inx 1937 22 , , , cord-010092-uftc8inx 1937 23 especially especially RB cord-010092-uftc8inx 1937 24 in in IN cord-010092-uftc8inx 1937 25 moderate moderate JJ cord-010092-uftc8inx 1937 26 cases case NNS cord-010092-uftc8inx 1937 27 of of IN cord-010092-uftc8inx 1937 28 anemias anemia NNS cord-010092-uftc8inx 1937 29 , , , cord-010092-uftc8inx 1937 30 where where WRB cord-010092-uftc8inx 1937 31 this this DT cord-010092-uftc8inx 1937 32 is be VBZ cord-010092-uftc8inx 1937 33 rarely rarely RB cord-010092-uftc8inx 1937 34 necessary necessary JJ cord-010092-uftc8inx 1937 35 . . . cord-010092-uftc8inx 1938 1 A a DT cord-010092-uftc8inx 1938 2 significant significant JJ cord-010092-uftc8inx 1938 3 number number NN cord-010092-uftc8inx 1938 4 of of IN cord-010092-uftc8inx 1938 5 patients patient NNS cord-010092-uftc8inx 1938 6 that that WDT cord-010092-uftc8inx 1938 7 were be VBD cord-010092-uftc8inx 1938 8 DAT DAT NNP cord-010092-uftc8inx 1938 9 positive positive JJ cord-010092-uftc8inx 1938 10 without without IN cord-010092-uftc8inx 1938 11 clinical clinical JJ cord-010092-uftc8inx 1938 12 symptoms symptom NNS cord-010092-uftc8inx 1938 13 may may MD cord-010092-uftc8inx 1938 14 later later RB cord-010092-uftc8inx 1938 15 develop develop VB cord-010092-uftc8inx 1938 16 AIHA AIHA NNP cord-010092-uftc8inx 1938 17 and and CC cord-010092-uftc8inx 1938 18 should should MD cord-010092-uftc8inx 1938 19 be be VB cord-010092-uftc8inx 1938 20 closely closely RB cord-010092-uftc8inx 1938 21 monitored monitor VBN cord-010092-uftc8inx 1938 22 . . . cord-010092-uftc8inx 1939 1 Background background NN cord-010092-uftc8inx 1939 2 : : : cord-010092-uftc8inx 1940 1 Autoimmune autoimmune JJ cord-010092-uftc8inx 1940 2 haemolytic haemolytic JJ cord-010092-uftc8inx 1940 3 anaemia anaemia NN cord-010092-uftc8inx 1940 4 ( ( -LRB- cord-010092-uftc8inx 1940 5 AIHA AIHA NNP cord-010092-uftc8inx 1940 6 ) ) -RRB- cord-010092-uftc8inx 1940 7 is be VBZ cord-010092-uftc8inx 1940 8 a a DT cord-010092-uftc8inx 1940 9 decompensated decompensate VBN cord-010092-uftc8inx 1940 10 acquired acquire VBN cord-010092-uftc8inx 1940 11 haemolysis haemolysis NN cord-010092-uftc8inx 1940 12 caused cause VBN cord-010092-uftc8inx 1940 13 by by IN cord-010092-uftc8inx 1940 14 the the DT cord-010092-uftc8inx 1940 15 host host NN cord-010092-uftc8inx 1940 16 's 's POS cord-010092-uftc8inx 1940 17 immune immune JJ cord-010092-uftc8inx 1940 18 system system NN cord-010092-uftc8inx 1940 19 acting act VBG cord-010092-uftc8inx 1940 20 against against IN cord-010092-uftc8inx 1940 21 its -PRON- PRP$ cord-010092-uftc8inx 1940 22 own own JJ cord-010092-uftc8inx 1940 23 red red JJ cord-010092-uftc8inx 1940 24 cell cell NN cord-010092-uftc8inx 1940 25 antigens antigen NNS cord-010092-uftc8inx 1940 26 . . . cord-010092-uftc8inx 1941 1 AIHA AIHA NNP cord-010092-uftc8inx 1941 2 is be VBZ cord-010092-uftc8inx 1941 3 a a DT cord-010092-uftc8inx 1941 4 rare rare JJ cord-010092-uftc8inx 1941 5 disorder disorder NN cord-010092-uftc8inx 1941 6 and and CC cord-010092-uftc8inx 1941 7 although although IN cord-010092-uftc8inx 1941 8 British British NNP cord-010092-uftc8inx 1941 9 Society Society NNP cord-010092-uftc8inx 1941 10 of of IN cord-010092-uftc8inx 1941 11 Haematology Haematology NNP cord-010092-uftc8inx 1941 12 ( ( -LRB- cord-010092-uftc8inx 1941 13 BSH BSH NNP cord-010092-uftc8inx 1941 14 ) ) -RRB- cord-010092-uftc8inx 1941 15 guidelines guideline NNS cord-010092-uftc8inx 1941 16 for for IN cord-010092-uftc8inx 1941 17 diagnosis diagnosis NN cord-010092-uftc8inx 1941 18 and and CC cord-010092-uftc8inx 1941 19 treatment treatment NN cord-010092-uftc8inx 1941 20 were be VBD cord-010092-uftc8inx 1941 21 published publish VBN cord-010092-uftc8inx 1941 22 in in IN cord-010092-uftc8inx 1941 23 February February NNP cord-010092-uftc8inx 1941 24 2017 2017 CD cord-010092-uftc8inx 1941 25 , , , cord-010092-uftc8inx 1941 26 there there EX cord-010092-uftc8inx 1941 27 is be VBZ cord-010092-uftc8inx 1941 28 little little JJ cord-010092-uftc8inx 1941 29 evidence evidence NN cord-010092-uftc8inx 1941 30 for for IN cord-010092-uftc8inx 1941 31 clinical clinical JJ cord-010092-uftc8inx 1941 32 practice practice NN cord-010092-uftc8inx 1941 33 in in IN cord-010092-uftc8inx 1941 34 the the DT cord-010092-uftc8inx 1941 35 United United NNP cord-010092-uftc8inx 1941 36 Kingdom Kingdom NNP cord-010092-uftc8inx 1941 37 . . . cord-010092-uftc8inx 1942 1 Aims aim VBZ cord-010092-uftc8inx 1942 2 : : : cord-010092-uftc8inx 1943 1 To to TO cord-010092-uftc8inx 1943 2 investigate investigate VB cord-010092-uftc8inx 1943 3 the the DT cord-010092-uftc8inx 1943 4 approach approach NN cord-010092-uftc8inx 1943 5 to to IN cord-010092-uftc8inx 1943 6 diagnosis diagnosis NN cord-010092-uftc8inx 1943 7 , , , cord-010092-uftc8inx 1943 8 investigation investigation NN cord-010092-uftc8inx 1943 9 and and CC cord-010092-uftc8inx 1943 10 management management NN cord-010092-uftc8inx 1943 11 of of IN cord-010092-uftc8inx 1943 12 patients patient NNS cord-010092-uftc8inx 1943 13 with with IN cord-010092-uftc8inx 1943 14 AIHA AIHA NNP cord-010092-uftc8inx 1943 15 in in IN cord-010092-uftc8inx 1943 16 English English NNP cord-010092-uftc8inx 1943 17 NHS NHS NNP cord-010092-uftc8inx 1943 18 Trusts Trusts NNPS cord-010092-uftc8inx 1943 19 . . . cord-010092-uftc8inx 1944 1 Methods method NNS cord-010092-uftc8inx 1944 2 : : : cord-010092-uftc8inx 1945 1 A a DT cord-010092-uftc8inx 1945 2 survey survey NN cord-010092-uftc8inx 1945 3 of of IN cord-010092-uftc8inx 1945 4 diagnostic diagnostic JJ cord-010092-uftc8inx 1945 5 and and CC cord-010092-uftc8inx 1945 6 management management NN cord-010092-uftc8inx 1945 7 practice practice NN cord-010092-uftc8inx 1945 8 was be VBD cord-010092-uftc8inx 1945 9 designed design VBN cord-010092-uftc8inx 1945 10 , , , cord-010092-uftc8inx 1945 11 piloted pilot VBN cord-010092-uftc8inx 1945 12 and and CC cord-010092-uftc8inx 1945 13 disseminated disseminate VBN cord-010092-uftc8inx 1945 14 to to IN cord-010092-uftc8inx 1945 15 clinical clinical JJ cord-010092-uftc8inx 1945 16 transfusion transfusion NN cord-010092-uftc8inx 1945 17 leads lead VBZ cord-010092-uftc8inx 1945 18 in in IN cord-010092-uftc8inx 1945 19 all all DT cord-010092-uftc8inx 1945 20 English english JJ cord-010092-uftc8inx 1945 21 acute acute JJ cord-010092-uftc8inx 1945 22 NHS NHS NNP cord-010092-uftc8inx 1945 23 trusts trust NNS cord-010092-uftc8inx 1945 24 from from IN cord-010092-uftc8inx 1945 25 November November NNP cord-010092-uftc8inx 1945 26 2017 2017 CD cord-010092-uftc8inx 1945 27 to to IN cord-010092-uftc8inx 1945 28 March March NNP cord-010092-uftc8inx 1945 29 2018 2018 CD cord-010092-uftc8inx 1945 30 . . . cord-010092-uftc8inx 1946 1 Completion completion NN cord-010092-uftc8inx 1946 2 was be VBD cord-010092-uftc8inx 1946 3 by by IN cord-010092-uftc8inx 1946 4 a a DT cord-010092-uftc8inx 1946 5 consultant consultant NN cord-010092-uftc8inx 1946 6 haematologist haematologist NN cord-010092-uftc8inx 1946 7 treating treat VBG cord-010092-uftc8inx 1946 8 patients patient NNS cord-010092-uftc8inx 1946 9 with with IN cord-010092-uftc8inx 1946 10 AIHA AIHA NNP cord-010092-uftc8inx 1946 11 but but CC cord-010092-uftc8inx 1946 12 a a DT cord-010092-uftc8inx 1946 13 response response NN cord-010092-uftc8inx 1946 14 that that WDT cord-010092-uftc8inx 1946 15 represented represent VBD cord-010092-uftc8inx 1946 16 a a DT cord-010092-uftc8inx 1946 17 departmental departmental JJ cord-010092-uftc8inx 1946 18 consensus consensus NN cord-010092-uftc8inx 1946 19 was be VBD cord-010092-uftc8inx 1946 20 encouraged encourage VBN cord-010092-uftc8inx 1946 21 . . . cord-010092-uftc8inx 1947 1 Results result NNS cord-010092-uftc8inx 1947 2 : : : cord-010092-uftc8inx 1948 1 Responses response NNS cord-010092-uftc8inx 1948 2 represented represent VBD cord-010092-uftc8inx 1948 3 42 42 CD cord-010092-uftc8inx 1948 4 % % NN cord-010092-uftc8inx 1948 5 ( ( -LRB- cord-010092-uftc8inx 1948 6 58/137 58/137 CD cord-010092-uftc8inx 1948 7 ) ) -RRB- cord-010092-uftc8inx 1948 8 of of IN cord-010092-uftc8inx 1948 9 English english JJ cord-010092-uftc8inx 1948 10 acute acute JJ cord-010092-uftc8inx 1948 11 trusts trust NNS cord-010092-uftc8inx 1948 12 . . . cord-010092-uftc8inx 1949 1 Median median JJ cord-010092-uftc8inx 1949 2 number number NN cord-010092-uftc8inx 1949 3 of of IN cord-010092-uftc8inx 1949 4 adults adult NNS cord-010092-uftc8inx 1949 5 with with IN cord-010092-uftc8inx 1949 6 AIHA AIHA NNP cord-010092-uftc8inx 1949 7 diagnosed diagnose VBD cord-010092-uftc8inx 1949 8 annually annually RB cord-010092-uftc8inx 1949 9 was be VBD cord-010092-uftc8inx 1949 10 4 4 CD cord-010092-uftc8inx 1949 11 - - SYM cord-010092-uftc8inx 1949 12 6 6 CD cord-010092-uftc8inx 1949 13 . . . cord-010092-uftc8inx 1950 1 In in IN cord-010092-uftc8inx 1950 2 the the DT cord-010092-uftc8inx 1950 3 preceding precede VBG cord-010092-uftc8inx 1950 4 5 5 CD cord-010092-uftc8inx 1950 5 years year NNS cord-010092-uftc8inx 1950 6 , , , cord-010092-uftc8inx 1950 7 31 31 CD cord-010092-uftc8inx 1950 8 % % NN cord-010092-uftc8inx 1950 9 ( ( -LRB- cord-010092-uftc8inx 1950 10 18/58 18/58 CD cord-010092-uftc8inx 1950 11 ) ) -RRB- cord-010092-uftc8inx 1950 12 recalled recall VBD cord-010092-uftc8inx 1950 13 at at IN cord-010092-uftc8inx 1950 14 least least RBS cord-010092-uftc8inx 1950 15 one one CD cord-010092-uftc8inx 1950 16 patient patient NN cord-010092-uftc8inx 1950 17 who who WP cord-010092-uftc8inx 1950 18 had have VBD cord-010092-uftc8inx 1950 19 died die VBN cord-010092-uftc8inx 1950 20 due due IN cord-010092-uftc8inx 1950 21 to to IN cord-010092-uftc8inx 1950 22 AIHA AIHA NNP cord-010092-uftc8inx 1950 23 . . . cord-010092-uftc8inx 1951 1 Although although IN cord-010092-uftc8inx 1951 2 7 7 CD cord-010092-uftc8inx 1951 3 % % NN cord-010092-uftc8inx 1951 4 ( ( -LRB- cord-010092-uftc8inx 1951 5 4/57 4/57 CD cord-010092-uftc8inx 1951 6 ) ) -RRB- cord-010092-uftc8inx 1951 7 undertook undertake VBD cord-010092-uftc8inx 1951 8 a a DT cord-010092-uftc8inx 1951 9 bone bone NN cord-010092-uftc8inx 1951 10 marrow marrow NN cord-010092-uftc8inx 1951 11 biopsy biopsy NN cord-010092-uftc8inx 1951 12 in in IN cord-010092-uftc8inx 1951 13 all all DT cord-010092-uftc8inx 1951 14 patients patient NNS cord-010092-uftc8inx 1951 15 , , , cord-010092-uftc8inx 1951 16 93 93 CD cord-010092-uftc8inx 1951 17 % % NN cord-010092-uftc8inx 1951 18 required require VBD cord-010092-uftc8inx 1951 19 additional additional JJ cord-010092-uftc8inx 1951 20 features feature NNS cord-010092-uftc8inx 1951 21 , , , cord-010092-uftc8inx 1951 22 mainly mainly RB cord-010092-uftc8inx 1951 23 : : : cord-010092-uftc8inx 1951 24 neoplasia neoplasia NN cord-010092-uftc8inx 1951 25 , , , cord-010092-uftc8inx 1951 26 age age NN cord-010092-uftc8inx 1951 27 over over IN cord-010092-uftc8inx 1951 28 60 60 CD cord-010092-uftc8inx 1951 29 or or CC cord-010092-uftc8inx 1951 30 being be VBG cord-010092-uftc8inx 1951 31 treatment treatment NN cord-010092-uftc8inx 1951 32 - - HYPH cord-010092-uftc8inx 1951 33 refractory refractory JJ cord-010092-uftc8inx 1951 34 . . . cord-010092-uftc8inx 1952 1 For for IN cord-010092-uftc8inx 1952 2 patients patient NNS cord-010092-uftc8inx 1952 3 with with IN cord-010092-uftc8inx 1952 4 suspected suspect VBN cord-010092-uftc8inx 1952 5 drug drug NN cord-010092-uftc8inx 1952 6 - - HYPH cord-010092-uftc8inx 1952 7 induced induce VBN cord-010092-uftc8inx 1952 8 immune immune JJ cord-010092-uftc8inx 1952 9 haemolysis haemolysis NN cord-010092-uftc8inx 1952 10 , , , cord-010092-uftc8inx 1952 11 59 59 CD cord-010092-uftc8inx 1952 12 % % NN cord-010092-uftc8inx 1952 13 ( ( -LRB- cord-010092-uftc8inx 1952 14 34/58 34/58 CD cord-010092-uftc8inx 1952 15 ) ) -RRB- cord-010092-uftc8inx 1952 16 would would MD cord-010092-uftc8inx 1952 17 not not RB cord-010092-uftc8inx 1952 18 organise organise VB cord-010092-uftc8inx 1952 19 confirmatory confirmatory JJ cord-010092-uftc8inx 1952 20 tests test NNS cord-010092-uftc8inx 1952 21 , , , cord-010092-uftc8inx 1952 22 either either CC cord-010092-uftc8inx 1952 23 because because IN cord-010092-uftc8inx 1952 24 it -PRON- PRP cord-010092-uftc8inx 1952 25 was be VBD cord-010092-uftc8inx 1952 26 considered consider VBN cord-010092-uftc8inx 1952 27 unnecessary unnecessary JJ cord-010092-uftc8inx 1952 28 ( ( -LRB- cord-010092-uftc8inx 1952 29 29/34 29/34 CD cord-010092-uftc8inx 1952 30 ) ) -RRB- cord-010092-uftc8inx 1952 31 , , , cord-010092-uftc8inx 1952 32 or or CC cord-010092-uftc8inx 1952 33 because because IN cord-010092-uftc8inx 1952 34 clinicians clinician NNS cord-010092-uftc8inx 1952 35 were be VBD cord-010092-uftc8inx 1952 36 unsure unsure JJ cord-010092-uftc8inx 1952 37 how how WRB cord-010092-uftc8inx 1952 38 to to TO cord-010092-uftc8inx 1952 39 access access VB cord-010092-uftc8inx 1952 40 tests test NNS cord-010092-uftc8inx 1952 41 ( ( -LRB- cord-010092-uftc8inx 1952 42 5/34 5/34 CD cord-010092-uftc8inx 1952 43 ) ) -RRB- cord-010092-uftc8inx 1952 44 . . . cord-010092-uftc8inx 1953 1 When when WRB cord-010092-uftc8inx 1953 2 determining determine VBG cord-010092-uftc8inx 1953 3 AIHA AIHA NNP cord-010092-uftc8inx 1953 4 subtype subtype NN cord-010092-uftc8inx 1953 5 , , , cord-010092-uftc8inx 1953 6 29 29 CD cord-010092-uftc8inx 1953 7 % % NN cord-010092-uftc8inx 1953 8 ( ( -LRB- cord-010092-uftc8inx 1953 9 17/58 17/58 CD cord-010092-uftc8inx 1953 10 ) ) -RRB- cord-010092-uftc8inx 1953 11 indicated indicate VBD cord-010092-uftc8inx 1953 12 there there EX cord-010092-uftc8inx 1953 13 were be VBD cord-010092-uftc8inx 1953 14 no no DT cord-010092-uftc8inx 1953 15 circumstances circumstance NNS cord-010092-uftc8inx 1953 16 in in IN cord-010092-uftc8inx 1953 17 which which WDT cord-010092-uftc8inx 1953 18 they -PRON- PRP cord-010092-uftc8inx 1953 19 would would MD cord-010092-uftc8inx 1953 20 undertake undertake VB cord-010092-uftc8inx 1953 21 cold cold JJ cord-010092-uftc8inx 1953 22 antibody antibody NN cord-010092-uftc8inx 1953 23 testing testing NN cord-010092-uftc8inx 1953 24 ( ( -LRB- cord-010092-uftc8inx 1953 25 antibody antibody NN cord-010092-uftc8inx 1953 26 titre titre NN cord-010092-uftc8inx 1953 27 and/or and/or CC cord-010092-uftc8inx 1953 28 thermal thermal JJ cord-010092-uftc8inx 1953 29 amplitude amplitude NN cord-010092-uftc8inx 1953 30 ) ) -RRB- cord-010092-uftc8inx 1953 31 , , , cord-010092-uftc8inx 1953 32 with with IN cord-010092-uftc8inx 1953 33 12 12 CD cord-010092-uftc8inx 1953 34 considering consider VBG cord-010092-uftc8inx 1953 35 this this DT cord-010092-uftc8inx 1953 36 unnecessary unnecessary JJ cord-010092-uftc8inx 1953 37 and and CC cord-010092-uftc8inx 1953 38 5 5 CD cord-010092-uftc8inx 1953 39 unsure unsure JJ cord-010092-uftc8inx 1953 40 how how WRB cord-010092-uftc8inx 1953 41 to to TO cord-010092-uftc8inx 1953 42 access access VB cord-010092-uftc8inx 1953 43 tests test NNS cord-010092-uftc8inx 1953 44 . . . cord-010092-uftc8inx 1954 1 In in IN cord-010092-uftc8inx 1954 2 4 4 CD cord-010092-uftc8inx 1954 3 clinical clinical JJ cord-010092-uftc8inx 1954 4 scenarios scenario NNS cord-010092-uftc8inx 1954 5 of of IN cord-010092-uftc8inx 1954 6 patients patient NNS cord-010092-uftc8inx 1954 7 with with IN cord-010092-uftc8inx 1954 8 AIHA AIHA NNP cord-010092-uftc8inx 1954 9 and and CC cord-010092-uftc8inx 1954 10 DAT DAT NNP cord-010092-uftc8inx 1954 11 positive positive JJ cord-010092-uftc8inx 1954 12 to to IN cord-010092-uftc8inx 1954 13 C3d C3d NNP cord-010092-uftc8inx 1954 14 AE AE NNP cord-010092-uftc8inx 1954 15 IgG igg NN cord-010092-uftc8inx 1954 16 AE AE NNP cord-010092-uftc8inx 1954 17 cold cold JJ cord-010092-uftc8inx 1954 18 associated associate VBD cord-010092-uftc8inx 1954 19 symptoms symptom NNS cord-010092-uftc8inx 1954 20 , , , cord-010092-uftc8inx 1954 21 up up IN cord-010092-uftc8inx 1954 22 to to TO cord-010092-uftc8inx 1954 23 87 87 CD cord-010092-uftc8inx 1954 24 % % NN cord-010092-uftc8inx 1954 25 ( ( -LRB- cord-010092-uftc8inx 1954 26 47/54 47/54 CD cord-010092-uftc8inx 1954 27 ) ) -RRB- cord-010092-uftc8inx 1954 28 of of IN cord-010092-uftc8inx 1954 29 respondents respondent NNS cord-010092-uftc8inx 1954 30 would would MD cord-010092-uftc8inx 1954 31 not not RB cord-010092-uftc8inx 1954 32 test test VB cord-010092-uftc8inx 1954 33 for for IN cord-010092-uftc8inx 1954 34 cold cold JJ cord-010092-uftc8inx 1954 35 antibodies antibody NNS cord-010092-uftc8inx 1954 36 . . . cord-010092-uftc8inx 1955 1 For for IN cord-010092-uftc8inx 1955 2 first first JJ cord-010092-uftc8inx 1955 3 line line NN cord-010092-uftc8inx 1955 4 treatment treatment NN cord-010092-uftc8inx 1955 5 of of IN cord-010092-uftc8inx 1955 6 primary primary JJ cord-010092-uftc8inx 1955 7 warm warm JJ cord-010092-uftc8inx 1955 8 AIHA AIHA NNP cord-010092-uftc8inx 1955 9 , , , cord-010092-uftc8inx 1955 10 mean mean JJ cord-010092-uftc8inx 1955 11 duration duration NN cord-010092-uftc8inx 1955 12 of of IN cord-010092-uftc8inx 1955 13 prednisolone prednisolone NN cord-010092-uftc8inx 1955 14 1 1 CD cord-010092-uftc8inx 1955 15 mg mg NNP cord-010092-uftc8inx 1955 16 / / SYM cord-010092-uftc8inx 1955 17 kg kg NNS cord-010092-uftc8inx 1955 18 given give VBN cord-010092-uftc8inx 1955 19 before before IN cord-010092-uftc8inx 1955 20 judging judge VBG cord-010092-uftc8inx 1955 21 the the DT cord-010092-uftc8inx 1955 22 patient patient NN cord-010092-uftc8inx 1955 23 refractory refractory NN cord-010092-uftc8inx 1955 24 and and CC cord-010092-uftc8inx 1955 25 reducing reduce VBG cord-010092-uftc8inx 1955 26 the the DT cord-010092-uftc8inx 1955 27 dose dose NN cord-010092-uftc8inx 1955 28 was be VBD cord-010092-uftc8inx 1955 29 3.5 3.5 CD cord-010092-uftc8inx 1955 30 weeks week NNS cord-010092-uftc8inx 1955 31 ( ( -LRB- cord-010092-uftc8inx 1955 32 SD SD NNP cord-010092-uftc8inx 1955 33 1.70 1.70 CD cord-010092-uftc8inx 1955 34 , , , cord-010092-uftc8inx 1955 35 range range NN cord-010092-uftc8inx 1955 36 1 1 CD cord-010092-uftc8inx 1955 37 - - SYM cord-010092-uftc8inx 1955 38 19 19 CD cord-010092-uftc8inx 1955 39 weeks week NNS cord-010092-uftc8inx 1955 40 ) ) -RRB- cord-010092-uftc8inx 1955 41 . . . cord-010092-uftc8inx 1956 1 Second second JJ cord-010092-uftc8inx 1956 2 line line NN cord-010092-uftc8inx 1956 3 treatment treatment NN cord-010092-uftc8inx 1956 4 of of IN cord-010092-uftc8inx 1956 5 choice choice NN cord-010092-uftc8inx 1956 6 was be VBD cord-010092-uftc8inx 1956 7 rituximab rituximab VBN cord-010092-uftc8inx 1956 8 for for IN cord-010092-uftc8inx 1956 9 82 82 CD cord-010092-uftc8inx 1956 10 % % NN cord-010092-uftc8inx 1956 11 ( ( -LRB- cord-010092-uftc8inx 1956 12 45/55 45/55 CD cord-010092-uftc8inx 1956 13 ) ) -RRB- cord-010092-uftc8inx 1956 14 of of IN cord-010092-uftc8inx 1956 15 respondents respondent NNS cord-010092-uftc8inx 1956 16 and and CC cord-010092-uftc8inx 1956 17 splenectomy splenectomy NN cord-010092-uftc8inx 1956 18 for for IN cord-010092-uftc8inx 1956 19 5 5 CD cord-010092-uftc8inx 1956 20 % % NN cord-010092-uftc8inx 1956 21 . . . cord-010092-uftc8inx 1957 1 Intravenous intravenous JJ cord-010092-uftc8inx 1957 2 immunoglobulin immunoglobulin NN cord-010092-uftc8inx 1957 3 and and CC cord-010092-uftc8inx 1957 4 splenectomy splenectomy NN cord-010092-uftc8inx 1957 5 were be VBD cord-010092-uftc8inx 1957 6 the the DT cord-010092-uftc8inx 1957 7 most most RBS cord-010092-uftc8inx 1957 8 cited cite VBN cord-010092-uftc8inx 1957 9 rescue rescue NN cord-010092-uftc8inx 1957 10 therapies therapy NNS cord-010092-uftc8inx 1957 11 . . . cord-010092-uftc8inx 1958 1 For for IN cord-010092-uftc8inx 1958 2 primary primary JJ cord-010092-uftc8inx 1958 3 cold cold JJ cord-010092-uftc8inx 1958 4 haemagglutinin haemagglutinin NNP cord-010092-uftc8inx 1958 5 disease disease NN cord-010092-uftc8inx 1958 6 ( ( -LRB- cord-010092-uftc8inx 1958 7 CHAD CHAD NNP cord-010092-uftc8inx 1958 8 ) ) -RRB- cord-010092-uftc8inx 1958 9 , , , cord-010092-uftc8inx 1958 10 first first JJ cord-010092-uftc8inx 1958 11 line line NN cord-010092-uftc8inx 1958 12 treatment treatment NN cord-010092-uftc8inx 1958 13 was be VBD cord-010092-uftc8inx 1958 14 rituximab rituximab NN cord-010092-uftc8inx 1958 15 - - HYPH cord-010092-uftc8inx 1958 16 based base VBN cord-010092-uftc8inx 1958 17 for for IN cord-010092-uftc8inx 1958 18 88 88 CD cord-010092-uftc8inx 1958 19 % % NN cord-010092-uftc8inx 1958 20 ( ( -LRB- cord-010092-uftc8inx 1958 21 49/56 49/56 CD cord-010092-uftc8inx 1958 22 ) ) -RRB- cord-010092-uftc8inx 1958 23 but but CC cord-010092-uftc8inx 1958 24 single single JJ cord-010092-uftc8inx 1958 25 agent agent NN cord-010092-uftc8inx 1958 26 steroid steroid NN cord-010092-uftc8inx 1958 27 for for IN cord-010092-uftc8inx 1958 28 9 9 CD cord-010092-uftc8inx 1958 29 % % NN cord-010092-uftc8inx 1958 30 . . . cord-010092-uftc8inx 1959 1 We -PRON- PRP cord-010092-uftc8inx 1959 2 also also RB cord-010092-uftc8inx 1959 3 explored explore VBD cord-010092-uftc8inx 1959 4 the the DT cord-010092-uftc8inx 1959 5 potential potential NN cord-010092-uftc8inx 1959 6 for for IN cord-010092-uftc8inx 1959 7 future future JJ cord-010092-uftc8inx 1959 8 audit audit NN cord-010092-uftc8inx 1959 9 and and CC cord-010092-uftc8inx 1959 10 research research NN cord-010092-uftc8inx 1959 11 . . . cord-010092-uftc8inx 1960 1 64 64 CD cord-010092-uftc8inx 1960 2 % % NN cord-010092-uftc8inx 1960 3 ( ( -LRB- cord-010092-uftc8inx 1960 4 37/58 37/58 CD cord-010092-uftc8inx 1960 5 ) ) -RRB- cord-010092-uftc8inx 1960 6 of of IN cord-010092-uftc8inx 1960 7 respondents respondent NNS cord-010092-uftc8inx 1960 8 were be VBD cord-010092-uftc8inx 1960 9 able able JJ cord-010092-uftc8inx 1960 10 to to TO cord-010092-uftc8inx 1960 11 identify identify VB cord-010092-uftc8inx 1960 12 patients patient NNS cord-010092-uftc8inx 1960 13 with with IN cord-010092-uftc8inx 1960 14 AIHA AIHA NNP cord-010092-uftc8inx 1960 15 who who WP cord-010092-uftc8inx 1960 16 previously previously RB cord-010092-uftc8inx 1960 17 required require VBD cord-010092-uftc8inx 1960 18 transfusion transfusion NN cord-010092-uftc8inx 1960 19 . . . cord-010092-uftc8inx 1961 1 96 96 CD cord-010092-uftc8inx 1961 2 % % NN cord-010092-uftc8inx 1961 3 ( ( -LRB- cord-010092-uftc8inx 1961 4 55/57 55/57 CD cord-010092-uftc8inx 1961 5 ) ) -RRB- cord-010092-uftc8inx 1961 6 of of IN cord-010092-uftc8inx 1961 7 respondents respondent NNS cord-010092-uftc8inx 1961 8 would would MD cord-010092-uftc8inx 1961 9 consider consider VB cord-010092-uftc8inx 1961 10 supporting support VBG cord-010092-uftc8inx 1961 11 a a DT cord-010092-uftc8inx 1961 12 registry registry NN cord-010092-uftc8inx 1961 13 of of IN cord-010092-uftc8inx 1961 14 patients patient NNS cord-010092-uftc8inx 1961 15 with with IN cord-010092-uftc8inx 1961 16 AIHA AIHA NNP cord-010092-uftc8inx 1961 17 requiring require VBG cord-010092-uftc8inx 1961 18 transfusion transfusion NN cord-010092-uftc8inx 1961 19 . . . cord-010092-uftc8inx 1962 1 The the DT cord-010092-uftc8inx 1962 2 key key JJ cord-010092-uftc8inx 1962 3 questions question NNS cord-010092-uftc8inx 1962 4 that that WDT cord-010092-uftc8inx 1962 5 respondents respondent NNS cord-010092-uftc8inx 1962 6 thought think VBD cord-010092-uftc8inx 1962 7 a a DT cord-010092-uftc8inx 1962 8 registry registry NN cord-010092-uftc8inx 1962 9 should should MD cord-010092-uftc8inx 1962 10 address address VB cord-010092-uftc8inx 1962 11 were be VBD cord-010092-uftc8inx 1962 12 : : : cord-010092-uftc8inx 1962 13 morbidity morbidity NN cord-010092-uftc8inx 1962 14 and and CC cord-010092-uftc8inx 1962 15 mortality mortality NN cord-010092-uftc8inx 1962 16 , , , cord-010092-uftc8inx 1962 17 treatment treatment NN cord-010092-uftc8inx 1962 18 response response NN cord-010092-uftc8inx 1962 19 , , , cord-010092-uftc8inx 1962 20 and and CC cord-010092-uftc8inx 1962 21 differences difference NNS cord-010092-uftc8inx 1962 22 in in IN cord-010092-uftc8inx 1962 23 the the DT cord-010092-uftc8inx 1962 24 diagnosis diagnosis NN cord-010092-uftc8inx 1962 25 and and CC cord-010092-uftc8inx 1962 26 treatment treatment NN cord-010092-uftc8inx 1962 27 of of IN cord-010092-uftc8inx 1962 28 AIHA AIHA NNP cord-010092-uftc8inx 1962 29 subtypes subtype NNS cord-010092-uftc8inx 1962 30 . . . cord-010092-uftc8inx 1963 1 There there EX cord-010092-uftc8inx 1963 2 was be VBD cord-010092-uftc8inx 1963 3 uncertainty uncertainty NN cord-010092-uftc8inx 1963 4 over over IN cord-010092-uftc8inx 1963 5 access access NN cord-010092-uftc8inx 1963 6 to to IN cord-010092-uftc8inx 1963 7 cold cold JJ cord-010092-uftc8inx 1963 8 and and CC cord-010092-uftc8inx 1963 9 drug drug NN cord-010092-uftc8inx 1963 10 - - HYPH cord-010092-uftc8inx 1963 11 induced induce VBN cord-010092-uftc8inx 1963 12 antibody antibody NN cord-010092-uftc8inx 1963 13 tests test NNS cord-010092-uftc8inx 1963 14 and and CC cord-010092-uftc8inx 1963 15 clinicians clinician NNS cord-010092-uftc8inx 1963 16 do do VBP cord-010092-uftc8inx 1963 17 not not RB cord-010092-uftc8inx 1963 18 always always RB cord-010092-uftc8inx 1963 19 conduct conduct VB cord-010092-uftc8inx 1963 20 BSHrecommended bshrecommended JJ cord-010092-uftc8inx 1963 21 cold cold JJ cord-010092-uftc8inx 1963 22 antibody antibody NN cord-010092-uftc8inx 1963 23 tests test NNS cord-010092-uftc8inx 1963 24 for for IN cord-010092-uftc8inx 1963 25 AIHA AIHA NNP cord-010092-uftc8inx 1963 26 with with IN cord-010092-uftc8inx 1963 27 C3d C3d NNP cord-010092-uftc8inx 1963 28 positive positive JJ cord-010092-uftc8inx 1963 29 DAT dat NN cord-010092-uftc8inx 1963 30 . . . cord-010092-uftc8inx 1964 1 Initial initial JJ cord-010092-uftc8inx 1964 2 treatment treatment NN cord-010092-uftc8inx 1964 3 of of IN cord-010092-uftc8inx 1964 4 primary primary JJ cord-010092-uftc8inx 1964 5 warm warm JJ cord-010092-uftc8inx 1964 6 AIHA AIHA NNP cord-010092-uftc8inx 1964 7 and and CC cord-010092-uftc8inx 1964 8 CHAD CHAD NNP cord-010092-uftc8inx 1964 9 broadly broadly RB cord-010092-uftc8inx 1964 10 matched match VBD cord-010092-uftc8inx 1964 11 BSH BSH NNP cord-010092-uftc8inx 1964 12 guidelines guideline NNS cord-010092-uftc8inx 1964 13 although although IN cord-010092-uftc8inx 1964 14 44 44 CD cord-010092-uftc8inx 1964 15 % % NN cord-010092-uftc8inx 1964 16 ( ( -LRB- cord-010092-uftc8inx 1964 17 25/57 25/57 CD cord-010092-uftc8inx 1964 18 ) ) -RRB- cord-010092-uftc8inx 1964 19 would would MD cord-010092-uftc8inx 1964 20 continue continue VB cord-010092-uftc8inx 1964 21 prednisolone prednisolone NN cord-010092-uftc8inx 1964 22 at at IN cord-010092-uftc8inx 1964 23 1 1 CD cord-010092-uftc8inx 1964 24 mg mg NNP cord-010092-uftc8inx 1964 25 / / SYM cord-010092-uftc8inx 1964 26 kg kg NNS cord-010092-uftc8inx 1964 27 beyond beyond IN cord-010092-uftc8inx 1964 28 the the DT cord-010092-uftc8inx 1964 29 recommended recommend VBN cord-010092-uftc8inx 1964 30 21 21 CD cord-010092-uftc8inx 1964 31 days day NNS cord-010092-uftc8inx 1964 32 before before IN cord-010092-uftc8inx 1964 33 starting start VBG cord-010092-uftc8inx 1964 34 a a DT cord-010092-uftc8inx 1964 35 taper taper NN cord-010092-uftc8inx 1964 36 , , , cord-010092-uftc8inx 1964 37 with with IN cord-010092-uftc8inx 1964 38 greater great JJR cord-010092-uftc8inx 1964 39 toxicity toxicity NN cord-010092-uftc8inx 1964 40 risk risk NN cord-010092-uftc8inx 1964 41 . . . cord-010092-uftc8inx 1965 1 Summary Summary NNP cord-010092-uftc8inx 1965 2 / / SYM cord-010092-uftc8inx 1965 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 1965 4 : : : cord-010092-uftc8inx 1966 1 The the DT cord-010092-uftc8inx 1966 2 findings finding NNS cord-010092-uftc8inx 1966 3 support support VBP cord-010092-uftc8inx 1966 4 the the DT cord-010092-uftc8inx 1966 5 need need NN cord-010092-uftc8inx 1966 6 for for IN cord-010092-uftc8inx 1966 7 a a DT cord-010092-uftc8inx 1966 8 range range NN cord-010092-uftc8inx 1966 9 of of IN cord-010092-uftc8inx 1966 10 research research NN cord-010092-uftc8inx 1966 11 initiatives initiative NNS cord-010092-uftc8inx 1966 12 , , , cord-010092-uftc8inx 1966 13 including include VBG cord-010092-uftc8inx 1966 14 creation creation NN cord-010092-uftc8inx 1966 15 of of IN cord-010092-uftc8inx 1966 16 an an DT cord-010092-uftc8inx 1966 17 AIHA AIHA NNP cord-010092-uftc8inx 1966 18 registry registry NN cord-010092-uftc8inx 1966 19 . . . cord-010092-uftc8inx 1967 1 Preoperative preoperative JJ cord-010092-uftc8inx 1967 2 anemia anemia NN cord-010092-uftc8inx 1967 3 is be VBZ cord-010092-uftc8inx 1967 4 common common JJ cord-010092-uftc8inx 1967 5 and and CC cord-010092-uftc8inx 1967 6 is be VBZ cord-010092-uftc8inx 1967 7 associated associate VBN cord-010092-uftc8inx 1967 8 with with IN cord-010092-uftc8inx 1967 9 adverse adverse JJ cord-010092-uftc8inx 1967 10 outcomes outcome NNS cord-010092-uftc8inx 1967 11 in in IN cord-010092-uftc8inx 1967 12 the the DT cord-010092-uftc8inx 1967 13 peri peri JJ cord-010092-uftc8inx 1967 14 - - HYPH cord-010092-uftc8inx 1967 15 operative operative JJ cord-010092-uftc8inx 1967 16 period period NN cord-010092-uftc8inx 1967 17 . . . cord-010092-uftc8inx 1968 1 Preoperative preoperative JJ cord-010092-uftc8inx 1968 2 anemia anemia NN cord-010092-uftc8inx 1968 3 also also RB cord-010092-uftc8inx 1968 4 increases increase VBZ cord-010092-uftc8inx 1968 5 the the DT cord-010092-uftc8inx 1968 6 risk risk NN cord-010092-uftc8inx 1968 7 of of IN cord-010092-uftc8inx 1968 8 allogeneic allogeneic VBG cord-010092-uftc8inx 1968 9 blood blood NN cord-010092-uftc8inx 1968 10 transfusions transfusion NNS cord-010092-uftc8inx 1968 11 , , , cord-010092-uftc8inx 1968 12 which which WDT cord-010092-uftc8inx 1968 13 may may MD cord-010092-uftc8inx 1968 14 lead lead VB cord-010092-uftc8inx 1968 15 to to IN cord-010092-uftc8inx 1968 16 increased increase VBN cord-010092-uftc8inx 1968 17 perioperative perioperative JJ cord-010092-uftc8inx 1968 18 mortality mortality NN cord-010092-uftc8inx 1968 19 , , , cord-010092-uftc8inx 1968 20 increased increase VBN cord-010092-uftc8inx 1968 21 hospital hospital NN cord-010092-uftc8inx 1968 22 length length NN cord-010092-uftc8inx 1968 23 of of IN cord-010092-uftc8inx 1968 24 stay stay NN cord-010092-uftc8inx 1968 25 and and CC cord-010092-uftc8inx 1968 26 infections infection NNS cord-010092-uftc8inx 1968 27 . . . cord-010092-uftc8inx 1969 1 Diagnosis diagnosis NN cord-010092-uftc8inx 1969 2 and and CC cord-010092-uftc8inx 1969 3 treatment treatment NN cord-010092-uftc8inx 1969 4 of of IN cord-010092-uftc8inx 1969 5 anemia anemia NN cord-010092-uftc8inx 1969 6 is be VBZ cord-010092-uftc8inx 1969 7 one one CD cord-010092-uftc8inx 1969 8 of of IN cord-010092-uftc8inx 1969 9 the the DT cord-010092-uftc8inx 1969 10 tenets tenet NNS cord-010092-uftc8inx 1969 11 of of IN cord-010092-uftc8inx 1969 12 patient patient JJ cord-010092-uftc8inx 1969 13 blood blood NN cord-010092-uftc8inx 1969 14 management management NN cord-010092-uftc8inx 1969 15 ( ( -LRB- cord-010092-uftc8inx 1969 16 PBM PBM NNP cord-010092-uftc8inx 1969 17 ) ) -RRB- cord-010092-uftc8inx 1969 18 , , , cord-010092-uftc8inx 1969 19 along along IN cord-010092-uftc8inx 1969 20 with with IN cord-010092-uftc8inx 1969 21 reduction reduction NN cord-010092-uftc8inx 1969 22 in in IN cord-010092-uftc8inx 1969 23 unnecessary unnecessary JJ cord-010092-uftc8inx 1969 24 transfusions transfusion NNS cord-010092-uftc8inx 1969 25 and and CC cord-010092-uftc8inx 1969 26 diagnostic diagnostic JJ cord-010092-uftc8inx 1969 27 phlebotomy phlebotomy NN cord-010092-uftc8inx 1969 28 , , , cord-010092-uftc8inx 1969 29 as as RB cord-010092-uftc8inx 1969 30 well well RB cord-010092-uftc8inx 1969 31 as as IN cord-010092-uftc8inx 1969 32 use use NN cord-010092-uftc8inx 1969 33 of of IN cord-010092-uftc8inx 1969 34 hemostatic hemostatic JJ cord-010092-uftc8inx 1969 35 agents agent NNS cord-010092-uftc8inx 1969 36 to to TO cord-010092-uftc8inx 1969 37 reduce reduce VB cord-010092-uftc8inx 1969 38 bleeding bleed VBG cord-010092-uftc8inx 1969 39 among among IN cord-010092-uftc8inx 1969 40 many many JJ cord-010092-uftc8inx 1969 41 others other NNS cord-010092-uftc8inx 1969 42 . . . cord-010092-uftc8inx 1970 1 Effective effective JJ cord-010092-uftc8inx 1970 2 PBM PBM NNP cord-010092-uftc8inx 1970 3 is be VBZ cord-010092-uftc8inx 1970 4 multi multi JJ cord-010092-uftc8inx 1970 5 - - JJ cord-010092-uftc8inx 1970 6 disciplinary disciplinary JJ cord-010092-uftc8inx 1970 7 , , , cord-010092-uftc8inx 1970 8 multi multi JJ cord-010092-uftc8inx 1970 9 - - JJ cord-010092-uftc8inx 1970 10 modal modal JJ cord-010092-uftc8inx 1970 11 , , , cord-010092-uftc8inx 1970 12 timely timely JJ cord-010092-uftc8inx 1970 13 , , , cord-010092-uftc8inx 1970 14 individualized individualized JJ cord-010092-uftc8inx 1970 15 and and CC cord-010092-uftc8inx 1970 16 patient patient RB cord-010092-uftc8inx 1970 17 - - HYPH cord-010092-uftc8inx 1970 18 centered center VBN cord-010092-uftc8inx 1970 19 . . . cord-010092-uftc8inx 1971 1 Early early JJ cord-010092-uftc8inx 1971 2 referral referral NN cord-010092-uftc8inx 1971 3 to to IN cord-010092-uftc8inx 1971 4 PBM PBM NNP cord-010092-uftc8inx 1971 5 and and CC cord-010092-uftc8inx 1971 6 multi multi JJ cord-010092-uftc8inx 1971 7 - - JJ cord-010092-uftc8inx 1971 8 modal modal JJ cord-010092-uftc8inx 1971 9 PBM PBM NNP cord-010092-uftc8inx 1971 10 interventions intervention NNS cord-010092-uftc8inx 1971 11 are be VBP cord-010092-uftc8inx 1971 12 associated associate VBN cord-010092-uftc8inx 1971 13 with with IN cord-010092-uftc8inx 1971 14 greater great JJR cord-010092-uftc8inx 1971 15 improvement improvement NN cord-010092-uftc8inx 1971 16 in in IN cord-010092-uftc8inx 1971 17 pre pre JJ cord-010092-uftc8inx 1971 18 - - JJ cord-010092-uftc8inx 1971 19 operative operative JJ cord-010092-uftc8inx 1971 20 hemoglobin hemoglobin NN cord-010092-uftc8inx 1971 21 . . . cord-010092-uftc8inx 1972 1 PBM PBM NNP cord-010092-uftc8inx 1972 2 has have VBZ cord-010092-uftc8inx 1972 3 been be VBN cord-010092-uftc8inx 1972 4 shown show VBN cord-010092-uftc8inx 1972 5 to to TO cord-010092-uftc8inx 1972 6 reduce reduce VB cord-010092-uftc8inx 1972 7 transfusions transfusion NNS cord-010092-uftc8inx 1972 8 and and CC cord-010092-uftc8inx 1972 9 cost cost NN cord-010092-uftc8inx 1972 10 , , , cord-010092-uftc8inx 1972 11 while while IN cord-010092-uftc8inx 1972 12 system system NN cord-010092-uftc8inx 1972 13 - - HYPH cord-010092-uftc8inx 1972 14 wide wide RB cord-010092-uftc8inx 1972 15 , , , cord-010092-uftc8inx 1972 16 multi multi JJ cord-010092-uftc8inx 1972 17 - - JJ cord-010092-uftc8inx 1972 18 modal modal JJ cord-010092-uftc8inx 1972 19 programs program NNS cord-010092-uftc8inx 1972 20 may may MD cord-010092-uftc8inx 1972 21 also also RB cord-010092-uftc8inx 1972 22 be be VB cord-010092-uftc8inx 1972 23 associated associate VBN cord-010092-uftc8inx 1972 24 with with IN cord-010092-uftc8inx 1972 25 improvement improvement NN cord-010092-uftc8inx 1972 26 in in IN cord-010092-uftc8inx 1972 27 mortality mortality NN cord-010092-uftc8inx 1972 28 . . . cord-010092-uftc8inx 1973 1 Using use VBG cord-010092-uftc8inx 1973 2 examples example NNS cord-010092-uftc8inx 1973 3 from from IN cord-010092-uftc8inx 1973 4 our -PRON- PRP$ cord-010092-uftc8inx 1973 5 local local JJ cord-010092-uftc8inx 1973 6 research research NN cord-010092-uftc8inx 1973 7 and and CC cord-010092-uftc8inx 1973 8 practice practice NN cord-010092-uftc8inx 1973 9 , , , cord-010092-uftc8inx 1973 10 I -PRON- PRP cord-010092-uftc8inx 1973 11 will will MD cord-010092-uftc8inx 1973 12 discuss discuss VB cord-010092-uftc8inx 1973 13 three three CD cord-010092-uftc8inx 1973 14 aspects aspect NNS cord-010092-uftc8inx 1973 15 of of IN cord-010092-uftc8inx 1973 16 PBM PBM NNP cord-010092-uftc8inx 1973 17 . . . cord-010092-uftc8inx 1974 1 Iron iron NN cord-010092-uftc8inx 1974 2 and and CC cord-010092-uftc8inx 1974 3 erythropoiesis erythropoiesis NN cord-010092-uftc8inx 1974 4 stimulating stimulate VBG cord-010092-uftc8inx 1974 5 agents agent NNS cord-010092-uftc8inx 1974 6 ( ( -LRB- cord-010092-uftc8inx 1974 7 ESA ESA NNP cord-010092-uftc8inx 1974 8 ) ) -RRB- cord-010092-uftc8inx 1974 9 are be VBP cord-010092-uftc8inx 1974 10 effective effective JJ cord-010092-uftc8inx 1974 11 , , , cord-010092-uftc8inx 1974 12 safe safe JJ cord-010092-uftc8inx 1974 13 and and CC cord-010092-uftc8inx 1974 14 used use VBD cord-010092-uftc8inx 1974 15 extensively extensively RB cord-010092-uftc8inx 1974 16 in in IN cord-010092-uftc8inx 1974 17 management management NN cord-010092-uftc8inx 1974 18 of of IN cord-010092-uftc8inx 1974 19 pre pre JJ cord-010092-uftc8inx 1974 20 - - JJ cord-010092-uftc8inx 1974 21 operative operative JJ cord-010092-uftc8inx 1974 22 anemia anemia NN cord-010092-uftc8inx 1974 23 . . . cord-010092-uftc8inx 1975 1 Previous previous JJ cord-010092-uftc8inx 1975 2 studies study NNS cord-010092-uftc8inx 1975 3 have have VBP cord-010092-uftc8inx 1975 4 questioned question VBN cord-010092-uftc8inx 1975 5 whether whether IN cord-010092-uftc8inx 1975 6 ESA ESA NNP cord-010092-uftc8inx 1975 7 leads lead VBZ cord-010092-uftc8inx 1975 8 to to IN cord-010092-uftc8inx 1975 9 increased increase VBN cord-010092-uftc8inx 1975 10 risk risk NN cord-010092-uftc8inx 1975 11 of of IN cord-010092-uftc8inx 1975 12 thrombosis thrombosis NN cord-010092-uftc8inx 1975 13 , , , cord-010092-uftc8inx 1975 14 however however RB cord-010092-uftc8inx 1975 15 , , , cord-010092-uftc8inx 1975 16 recent recent JJ cord-010092-uftc8inx 1975 17 systematic systematic JJ cord-010092-uftc8inx 1975 18 reviews review NNS cord-010092-uftc8inx 1975 19 do do VBP cord-010092-uftc8inx 1975 20 not not RB cord-010092-uftc8inx 1975 21 support support VB cord-010092-uftc8inx 1975 22 these these DT cord-010092-uftc8inx 1975 23 concerns concern NNS cord-010092-uftc8inx 1975 24 . . . cord-010092-uftc8inx 1976 1 Another another DT cord-010092-uftc8inx 1976 2 PBM PBM NNP cord-010092-uftc8inx 1976 3 approach approach NN cord-010092-uftc8inx 1976 4 is be VBZ cord-010092-uftc8inx 1976 5 to to TO cord-010092-uftc8inx 1976 6 reduce reduce VB cord-010092-uftc8inx 1976 7 bleeding bleeding NN cord-010092-uftc8inx 1976 8 during during IN cord-010092-uftc8inx 1976 9 surgery surgery NN cord-010092-uftc8inx 1976 10 by by IN cord-010092-uftc8inx 1976 11 using use VBG cord-010092-uftc8inx 1976 12 hemostatic hemostatic JJ cord-010092-uftc8inx 1976 13 agents agent NNS cord-010092-uftc8inx 1976 14 such such JJ cord-010092-uftc8inx 1976 15 as as IN cord-010092-uftc8inx 1976 16 tranexamic tranexamic JJ cord-010092-uftc8inx 1976 17 acid acid NN cord-010092-uftc8inx 1976 18 ( ( -LRB- cord-010092-uftc8inx 1976 19 TXA TXA NNP cord-010092-uftc8inx 1976 20 ) ) -RRB- cord-010092-uftc8inx 1976 21 . . . cord-010092-uftc8inx 1977 1 TXA TXA NNP cord-010092-uftc8inx 1977 2 reduces reduce VBZ cord-010092-uftc8inx 1977 3 transfusion transfusion NN cord-010092-uftc8inx 1977 4 requirements requirement NNS cord-010092-uftc8inx 1977 5 in in IN cord-010092-uftc8inx 1977 6 knee knee NN cord-010092-uftc8inx 1977 7 and and CC cord-010092-uftc8inx 1977 8 hip hip NN cord-010092-uftc8inx 1977 9 arthroplasty arthroplasty NN cord-010092-uftc8inx 1977 10 , , , cord-010092-uftc8inx 1977 11 and and CC cord-010092-uftc8inx 1977 12 is be VBZ cord-010092-uftc8inx 1977 13 safe safe JJ cord-010092-uftc8inx 1977 14 , , , cord-010092-uftc8inx 1977 15 widely widely RB cord-010092-uftc8inx 1977 16 available available JJ cord-010092-uftc8inx 1977 17 and and CC cord-010092-uftc8inx 1977 18 relatively relatively RB cord-010092-uftc8inx 1977 19 cheap cheap JJ cord-010092-uftc8inx 1977 20 . . . cord-010092-uftc8inx 1978 1 TXA TXA NNP cord-010092-uftc8inx 1978 2 is be VBZ cord-010092-uftc8inx 1978 3 effective effective JJ cord-010092-uftc8inx 1978 4 in in IN cord-010092-uftc8inx 1978 5 both both CC cord-010092-uftc8inx 1978 6 anemic anemic JJ cord-010092-uftc8inx 1978 7 and and CC cord-010092-uftc8inx 1978 8 non non JJ cord-010092-uftc8inx 1978 9 - - JJ cord-010092-uftc8inx 1978 10 anemic anemic JJ cord-010092-uftc8inx 1978 11 patients patient NNS cord-010092-uftc8inx 1978 12 , , , cord-010092-uftc8inx 1978 13 making make VBG cord-010092-uftc8inx 1978 14 it -PRON- PRP cord-010092-uftc8inx 1978 15 an an DT cord-010092-uftc8inx 1978 16 attractive attractive JJ cord-010092-uftc8inx 1978 17 universal universal JJ cord-010092-uftc8inx 1978 18 PBM PBM NNP cord-010092-uftc8inx 1978 19 strategy strategy NN cord-010092-uftc8inx 1978 20 . . . cord-010092-uftc8inx 1979 1 Finally finally RB cord-010092-uftc8inx 1979 2 , , , cord-010092-uftc8inx 1979 3 recommendations recommendation NNS cord-010092-uftc8inx 1979 4 and and CC cord-010092-uftc8inx 1979 5 evidence evidence NN cord-010092-uftc8inx 1979 6 - - HYPH cord-010092-uftc8inx 1979 7 based base VBN cord-010092-uftc8inx 1979 8 guidelines guideline NNS cord-010092-uftc8inx 1979 9 on on IN cord-010092-uftc8inx 1979 10 PBM PBM NNP cord-010092-uftc8inx 1979 11 exist exist VBP cord-010092-uftc8inx 1979 12 , , , cord-010092-uftc8inx 1979 13 including include VBG cord-010092-uftc8inx 1979 14 the the DT cord-010092-uftc8inx 1979 15 most most RBS cord-010092-uftc8inx 1979 16 recent recent JJ cord-010092-uftc8inx 1979 17 international international JJ cord-010092-uftc8inx 1979 18 guidelines guideline NNS cord-010092-uftc8inx 1979 19 developed develop VBN cord-010092-uftc8inx 1979 20 by by IN cord-010092-uftc8inx 1979 21 the the DT cord-010092-uftc8inx 1979 22 PBM PBM NNP cord-010092-uftc8inx 1979 23 International International NNP cord-010092-uftc8inx 1979 24 Consensus Consensus NNP cord-010092-uftc8inx 1979 25 Conference Conference NNP cord-010092-uftc8inx 1979 26 . . . cord-010092-uftc8inx 1980 1 However however RB cord-010092-uftc8inx 1980 2 , , , cord-010092-uftc8inx 1980 3 knowledge knowledge NN cord-010092-uftc8inx 1980 4 translation translation NN cord-010092-uftc8inx 1980 5 in in IN cord-010092-uftc8inx 1980 6 PBM PBM NNP cord-010092-uftc8inx 1980 7 has have VBZ cord-010092-uftc8inx 1980 8 been be VBN cord-010092-uftc8inx 1980 9 a a DT cord-010092-uftc8inx 1980 10 problem problem NN cord-010092-uftc8inx 1980 11 and and CC cord-010092-uftc8inx 1980 12 a a DT cord-010092-uftc8inx 1980 13 number number NN cord-010092-uftc8inx 1980 14 of of IN cord-010092-uftc8inx 1980 15 barriers barrier NNS cord-010092-uftc8inx 1980 16 to to IN cord-010092-uftc8inx 1980 17 its -PRON- PRP$ cord-010092-uftc8inx 1980 18 implementation implementation NN cord-010092-uftc8inx 1980 19 have have VBP cord-010092-uftc8inx 1980 20 been be VBN cord-010092-uftc8inx 1980 21 identified identify VBN cord-010092-uftc8inx 1980 22 . . . cord-010092-uftc8inx 1981 1 These these DT cord-010092-uftc8inx 1981 2 include include VBP cord-010092-uftc8inx 1981 3 perceived perceive VBN cord-010092-uftc8inx 1981 4 or or CC cord-010092-uftc8inx 1981 5 actual actual JJ cord-010092-uftc8inx 1981 6 lack lack NN cord-010092-uftc8inx 1981 7 of of IN cord-010092-uftc8inx 1981 8 expertise expertise NN cord-010092-uftc8inx 1981 9 , , , cord-010092-uftc8inx 1981 10 time time NN cord-010092-uftc8inx 1981 11 , , , cord-010092-uftc8inx 1981 12 and and CC cord-010092-uftc8inx 1981 13 resources resource NNS cord-010092-uftc8inx 1981 14 , , , cord-010092-uftc8inx 1981 15 as as RB cord-010092-uftc8inx 1981 16 well well RB cord-010092-uftc8inx 1981 17 as as IN cord-010092-uftc8inx 1981 18 lack lack NN cord-010092-uftc8inx 1981 19 of of IN cord-010092-uftc8inx 1981 20 physician physician NN cord-010092-uftc8inx 1981 21 and and CC cord-010092-uftc8inx 1981 22 patient patient JJ cord-010092-uftc8inx 1981 23 engagement engagement NN cord-010092-uftc8inx 1981 24 . . . cord-010092-uftc8inx 1982 1 One one CD cord-010092-uftc8inx 1982 2 way way NN cord-010092-uftc8inx 1982 3 to to TO cord-010092-uftc8inx 1982 4 address address VB cord-010092-uftc8inx 1982 5 patient patient JJ cord-010092-uftc8inx 1982 6 engagement engagement NN cord-010092-uftc8inx 1982 7 is be VBZ cord-010092-uftc8inx 1982 8 education education NN cord-010092-uftc8inx 1982 9 through through IN cord-010092-uftc8inx 1982 10 character character NN cord-010092-uftc8inx 1982 11 driven drive VBN cord-010092-uftc8inx 1982 12 animation animation NN cord-010092-uftc8inx 1982 13 and and CC cord-010092-uftc8inx 1982 14 we -PRON- PRP cord-010092-uftc8inx 1982 15 are be VBP cord-010092-uftc8inx 1982 16 currently currently RB cord-010092-uftc8inx 1982 17 trying try VBG cord-010092-uftc8inx 1982 18 this this DT cord-010092-uftc8inx 1982 19 approach approach NN cord-010092-uftc8inx 1982 20 . . . cord-010092-uftc8inx 1983 1 4A 4a LS cord-010092-uftc8inx 1983 2 - - : cord-010092-uftc8inx 1983 3 S17 S17 NNP cord-010092-uftc8inx 1983 4 - - HYPH cord-010092-uftc8inx 1983 5 02 02 CD cord-010092-uftc8inx 1983 6 LOW low JJ cord-010092-uftc8inx 1983 7 VS VS NNP cord-010092-uftc8inx 1983 8 . . . cord-010092-uftc8inx 1984 1 HIGH high JJ cord-010092-uftc8inx 1984 2 HEMOGLOBIN hemoglobin NN cord-010092-uftc8inx 1984 3 TRIGGER trigger NN cord-010092-uftc8inx 1984 4 FOR for IN cord-010092-uftc8inx 1984 5 TRANSFUSION transfusion NN cord-010092-uftc8inx 1984 6 IN in IN cord-010092-uftc8inx 1984 7 _SP cord-010092-uftc8inx 1984 8 VASCULAR vascular JJ cord-010092-uftc8inx 1984 9 SURGERY surgery NN cord-010092-uftc8inx 1984 10 ( ( -LRB- cord-010092-uftc8inx 1984 11 TV tv NN cord-010092-uftc8inx 1984 12 ) ) -RRB- cord-010092-uftc8inx 1984 13 : : : cord-010092-uftc8inx 1985 1 A a DT cord-010092-uftc8inx 1985 2 RANDOMIZED RANDOMIZED NNP cord-010092-uftc8inx 1985 3 CLINICAL clinical JJ cord-010092-uftc8inx 1985 4 _SP cord-010092-uftc8inx 1985 5 FEASIBILITY feasibility NN cord-010092-uftc8inx 1985 6 TRIAL trial NN cord-010092-uftc8inx 1985 7 ( ( -LRB- cord-010092-uftc8inx 1985 8 THE the DT cord-010092-uftc8inx 1985 9 TV tv NN cord-010092-uftc8inx 1985 10 TRIAL trial NN cord-010092-uftc8inx 1985 11 ) ) -RRB- cord-010092-uftc8inx 1986 1 Background background NN cord-010092-uftc8inx 1986 2 : : : cord-010092-uftc8inx 1987 1 Current current JJ cord-010092-uftc8inx 1987 2 guidelines guideline NNS cord-010092-uftc8inx 1987 3 advocate advocate NN cord-010092-uftc8inx 1987 4 to to TO cord-010092-uftc8inx 1987 5 limit limit VB cord-010092-uftc8inx 1987 6 red red JJ cord-010092-uftc8inx 1987 7 - - HYPH cord-010092-uftc8inx 1987 8 cell cell NN cord-010092-uftc8inx 1987 9 transfusion transfusion NN cord-010092-uftc8inx 1987 10 during during IN cord-010092-uftc8inx 1987 11 surgery surgery NN cord-010092-uftc8inx 1987 12 , , , cord-010092-uftc8inx 1987 13 but but CC cord-010092-uftc8inx 1987 14 the the DT cord-010092-uftc8inx 1987 15 feasibility feasibility NN cord-010092-uftc8inx 1987 16 and and CC cord-010092-uftc8inx 1987 17 safety safety NN cord-010092-uftc8inx 1987 18 of of IN cord-010092-uftc8inx 1987 19 such such JJ cord-010092-uftc8inx 1987 20 strategy strategy NN cord-010092-uftc8inx 1987 21 remains remain VBZ cord-010092-uftc8inx 1987 22 unclear unclear JJ cord-010092-uftc8inx 1987 23 as as IN cord-010092-uftc8inx 1987 24 the the DT cord-010092-uftc8inx 1987 25 majority majority NN cord-010092-uftc8inx 1987 26 of of IN cord-010092-uftc8inx 1987 27 evidence evidence NN cord-010092-uftc8inx 1987 28 is be VBZ cord-010092-uftc8inx 1987 29 based base VBN cord-010092-uftc8inx 1987 30 on on IN cord-010092-uftc8inx 1987 31 postoperative postoperative JJ cord-010092-uftc8inx 1987 32 stable stable JJ cord-010092-uftc8inx 1987 33 patients patient NNS cord-010092-uftc8inx 1987 34 . . . cord-010092-uftc8inx 1988 1 Aims aim VBZ cord-010092-uftc8inx 1988 2 : : : cord-010092-uftc8inx 1989 1 We -PRON- PRP cord-010092-uftc8inx 1989 2 assessed assess VBD cord-010092-uftc8inx 1989 3 the the DT cord-010092-uftc8inx 1989 4 effects effect NNS cord-010092-uftc8inx 1989 5 of of IN cord-010092-uftc8inx 1989 6 a a DT cord-010092-uftc8inx 1989 7 protocol protocol NN cord-010092-uftc8inx 1989 8 aiming aim VBG cord-010092-uftc8inx 1989 9 to to TO cord-010092-uftc8inx 1989 10 restrict restrict VB cord-010092-uftc8inx 1989 11 red red JJ cord-010092-uftc8inx 1989 12 - - HYPH cord-010092-uftc8inx 1989 13 cell cell NN cord-010092-uftc8inx 1989 14 transfusion transfusion NN cord-010092-uftc8inx 1989 15 during during IN cord-010092-uftc8inx 1989 16 elective elective JJ cord-010092-uftc8inx 1989 17 vascular vascular JJ cord-010092-uftc8inx 1989 18 surgery surgery NN cord-010092-uftc8inx 1989 19 . . . cord-010092-uftc8inx 1990 1 Methods method NNS cord-010092-uftc8inx 1990 2 : : : cord-010092-uftc8inx 1990 3 Fifty fifty CD cord-010092-uftc8inx 1990 4 - - HYPH cord-010092-uftc8inx 1990 5 eight eight CD cord-010092-uftc8inx 1990 6 patients patient NNS cord-010092-uftc8inx 1990 7 scheduled schedule VBN cord-010092-uftc8inx 1990 8 for for IN cord-010092-uftc8inx 1990 9 lower low JJR cord-010092-uftc8inx 1990 10 limb limb NN cord-010092-uftc8inx 1990 11 - - HYPH cord-010092-uftc8inx 1990 12 bypass bypass NN cord-010092-uftc8inx 1990 13 or or CC cord-010092-uftc8inx 1990 14 open open JJ cord-010092-uftc8inx 1990 15 surgery surgery NN cord-010092-uftc8inx 1990 16 of of IN cord-010092-uftc8inx 1990 17 abdominal abdominal JJ cord-010092-uftc8inx 1990 18 aortic aortic JJ cord-010092-uftc8inx 1990 19 aneurysm aneurysm NN cord-010092-uftc8inx 1990 20 were be VBD cord-010092-uftc8inx 1990 21 randomized randomize VBN cord-010092-uftc8inx 1990 22 to to IN cord-010092-uftc8inx 1990 23 a a DT cord-010092-uftc8inx 1990 24 low low JJ cord-010092-uftc8inx 1990 25 - - HYPH cord-010092-uftc8inx 1990 26 trigger trigger NN cord-010092-uftc8inx 1990 27 ( ( -LRB- cord-010092-uftc8inx 1990 28 hemoglobin hemoglobin NN cord-010092-uftc8inx 1990 29 < < XX cord-010092-uftc8inx 1990 30 8.0 8.0 CD cord-010092-uftc8inx 1990 31 g/ g/ NNP cord-010092-uftc8inx 1990 32 dl dl NN cord-010092-uftc8inx 1990 33 , , , cord-010092-uftc8inx 1990 34 5 5 CD cord-010092-uftc8inx 1990 35 mmol mmol NNP cord-010092-uftc8inx 1990 36 / / SYM cord-010092-uftc8inx 1990 37 L l NN cord-010092-uftc8inx 1990 38 ) ) -RRB- cord-010092-uftc8inx 1990 39 vs. vs. IN cord-010092-uftc8inx 1990 40 high high JJ cord-010092-uftc8inx 1990 41 - - HYPH cord-010092-uftc8inx 1990 42 trigger trigger NN cord-010092-uftc8inx 1990 43 ( ( -LRB- cord-010092-uftc8inx 1990 44 hemoglobin hemoglobin NN cord-010092-uftc8inx 1990 45 < < XX cord-010092-uftc8inx 1990 46 9.7 9.7 CD cord-010092-uftc8inx 1990 47 g g NN cord-010092-uftc8inx 1990 48 / / SYM cord-010092-uftc8inx 1990 49 dl dl NN cord-010092-uftc8inx 1990 50 , , , cord-010092-uftc8inx 1990 51 6 6 CD cord-010092-uftc8inx 1990 52 mmol mmol NNP cord-010092-uftc8inx 1990 53 / / SYM cord-010092-uftc8inx 1990 54 L L NNP cord-010092-uftc8inx 1990 55 ) ) -RRB- cord-010092-uftc8inx 1990 56 for for IN cord-010092-uftc8inx 1990 57 red red JJ cord-010092-uftc8inx 1990 58 - - HYPH cord-010092-uftc8inx 1990 59 cell cell NN cord-010092-uftc8inx 1990 60 transfusion transfusion NN cord-010092-uftc8inx 1990 61 throughout throughout IN cord-010092-uftc8inx 1990 62 hospitalization hospitalization NN cord-010092-uftc8inx 1990 63 . . . cord-010092-uftc8inx 1991 1 Intraoperative intraoperative JJ cord-010092-uftc8inx 1991 2 change change NN cord-010092-uftc8inx 1991 3 in in IN cord-010092-uftc8inx 1991 4 cerebral cerebral JJ cord-010092-uftc8inx 1991 5 - - HYPH cord-010092-uftc8inx 1991 6 and and CC cord-010092-uftc8inx 1991 7 muscle muscle NN cord-010092-uftc8inx 1991 8 tissue tissue NN cord-010092-uftc8inx 1991 9 oxygenation oxygenation NN cord-010092-uftc8inx 1991 10 was be VBD cord-010092-uftc8inx 1991 11 assessed assess VBN cord-010092-uftc8inx 1991 12 by by IN cord-010092-uftc8inx 1991 13 near near JJ cord-010092-uftc8inx 1991 14 - - HYPH cord-010092-uftc8inx 1991 15 infrared infrared JJ cord-010092-uftc8inx 1991 16 spectroscopy spectroscopy NN cord-010092-uftc8inx 1991 17 . . . cord-010092-uftc8inx 1992 1 We -PRON- PRP cord-010092-uftc8inx 1992 2 used use VBD cord-010092-uftc8inx 1992 3 a a DT cord-010092-uftc8inx 1992 4 nationwide nationwide JJ cord-010092-uftc8inx 1992 5 registry registry NN cord-010092-uftc8inx 1992 6 to to TO cord-010092-uftc8inx 1992 7 collect collect VB cord-010092-uftc8inx 1992 8 data datum NNS cord-010092-uftc8inx 1992 9 on on IN cord-010092-uftc8inx 1992 10 death death NN cord-010092-uftc8inx 1992 11 and and CC cord-010092-uftc8inx 1992 12 major major JJ cord-010092-uftc8inx 1992 13 cardiovascular cardiovascular JJ cord-010092-uftc8inx 1992 14 events event NNS cord-010092-uftc8inx 1992 15 , , , cord-010092-uftc8inx 1992 16 which which WDT cord-010092-uftc8inx 1992 17 encompassed encompass VBD cord-010092-uftc8inx 1992 18 ( ( -LRB- cord-010092-uftc8inx 1992 19 1 1 CD cord-010092-uftc8inx 1992 20 ) ) -RRB- cord-010092-uftc8inx 1992 21 severe severe JJ cord-010092-uftc8inx 1992 22 adverse adverse JJ cord-010092-uftc8inx 1992 23 transfusion transfusion NN cord-010092-uftc8inx 1992 24 reaction reaction NN cord-010092-uftc8inx 1992 25 , , , cord-010092-uftc8inx 1992 26 ( ( -LRB- cord-010092-uftc8inx 1992 27 2 2 LS cord-010092-uftc8inx 1992 28 ) ) -RRB- cord-010092-uftc8inx 1992 29 acute acute JJ cord-010092-uftc8inx 1992 30 myocardial myocardial JJ cord-010092-uftc8inx 1992 31 infarction infarction NN cord-010092-uftc8inx 1992 32 , , , cord-010092-uftc8inx 1992 33 ( ( -LRB- cord-010092-uftc8inx 1992 34 3 3 LS cord-010092-uftc8inx 1992 35 ) ) -RRB- cord-010092-uftc8inx 1992 36 stroke stroke NN cord-010092-uftc8inx 1992 37 , , , cord-010092-uftc8inx 1992 38 ( ( -LRB- cord-010092-uftc8inx 1992 39 4 4 LS cord-010092-uftc8inx 1992 40 ) ) -RRB- cord-010092-uftc8inx 1992 41 new new JJ cord-010092-uftc8inx 1992 42 - - HYPH cord-010092-uftc8inx 1992 43 onset onset NN cord-010092-uftc8inx 1992 44 renal renal JJ cord-010092-uftc8inx 1992 45 replacement replacement NN cord-010092-uftc8inx 1992 46 therapy therapy NN cord-010092-uftc8inx 1992 47 , , , cord-010092-uftc8inx 1992 48 ( ( -LRB- cord-010092-uftc8inx 1992 49 5 5 LS cord-010092-uftc8inx 1992 50 ) ) -RRB- cord-010092-uftc8inx 1992 51 vascular vascular JJ cord-010092-uftc8inx 1992 52 reoperation reoperation NN cord-010092-uftc8inx 1992 53 , , , cord-010092-uftc8inx 1992 54 and and CC cord-010092-uftc8inx 1992 55 ( ( -LRB- cord-010092-uftc8inx 1992 56 6 6 CD cord-010092-uftc8inx 1992 57 ) ) -RRB- cord-010092-uftc8inx 1992 58 amputation amputation NN cord-010092-uftc8inx 1992 59 of of IN cord-010092-uftc8inx 1992 60 the the DT cord-010092-uftc8inx 1992 61 lower low JJR cord-010092-uftc8inx 1992 62 limb limb NN cord-010092-uftc8inx 1992 63 . . . cord-010092-uftc8inx 1993 1 Results result NNS cord-010092-uftc8inx 1993 2 : : : cord-010092-uftc8inx 1994 1 The the DT cord-010092-uftc8inx 1994 2 primary primary JJ cord-010092-uftc8inx 1994 3 outcome outcome NN cord-010092-uftc8inx 1994 4 , , , cord-010092-uftc8inx 1994 5 mean mean VBP cord-010092-uftc8inx 1994 6 hemoglobin hemoglobin NN cord-010092-uftc8inx 1994 7 within within IN cord-010092-uftc8inx 1994 8 15 15 CD cord-010092-uftc8inx 1994 9 days day NNS cord-010092-uftc8inx 1994 10 of of IN cord-010092-uftc8inx 1994 11 surgery surgery NN cord-010092-uftc8inx 1994 12 , , , cord-010092-uftc8inx 1994 13 was be VBD cord-010092-uftc8inx 1994 14 significantly significantly RB cord-010092-uftc8inx 1994 15 lower low JJR cord-010092-uftc8inx 1994 16 in in IN cord-010092-uftc8inx 1994 17 the the DT cord-010092-uftc8inx 1994 18 low low JJ cord-010092-uftc8inx 1994 19 - - HYPH cord-010092-uftc8inx 1994 20 trigger trigger NN cord-010092-uftc8inx 1994 21 group group NN cord-010092-uftc8inx 1994 22 : : : cord-010092-uftc8inx 1995 1 9.46 9.46 CD cord-010092-uftc8inx 1995 2 g g NN cord-010092-uftc8inx 1995 3 / / SYM cord-010092-uftc8inx 1995 4 dl dl NN cord-010092-uftc8inx 1996 1 vs. vs. FW cord-010092-uftc8inx 1996 2 10.33 10.33 CD cord-010092-uftc8inx 1996 3 g g NNP cord-010092-uftc8inx 1996 4 / / SYM cord-010092-uftc8inx 1996 5 dl dl NN cord-010092-uftc8inx 1996 6 in in IN cord-010092-uftc8inx 1996 7 the the DT cord-010092-uftc8inx 1996 8 hightrigger hightrigger NNP cord-010092-uftc8inx 1996 9 group group NN cord-010092-uftc8inx 1996 10 ( ( -LRB- cord-010092-uftc8inx 1996 11 mean mean JJ cord-010092-uftc8inx 1996 12 difference difference NN cord-010092-uftc8inx 1996 13 0.87 0.87 CD cord-010092-uftc8inx 1996 14 g g NN cord-010092-uftc8inx 1996 15 / / SYM cord-010092-uftc8inx 1996 16 dl dl NN cord-010092-uftc8inx 1996 17 ; ; : cord-010092-uftc8inx 1996 18 P p NN cord-010092-uftc8inx 1996 19 = = SYM cord-010092-uftc8inx 1996 20 0.022 0.022 CD cord-010092-uftc8inx 1996 21 , , , cord-010092-uftc8inx 1996 22 longitudinal longitudinal JJ cord-010092-uftc8inx 1996 23 analysis analysis NN cord-010092-uftc8inx 1996 24 ) ) -RRB- cord-010092-uftc8inx 1997 1 as as IN cord-010092-uftc8inx 1997 2 were be VBD cord-010092-uftc8inx 1997 3 units unit NNS cord-010092-uftc8inx 1997 4 of of IN cord-010092-uftc8inx 1997 5 red red JJ cord-010092-uftc8inx 1997 6 - - HYPH cord-010092-uftc8inx 1997 7 cells cell NNS cord-010092-uftc8inx 1997 8 transfused transfuse VBN cord-010092-uftc8inx 1997 9 ( ( -LRB- cord-010092-uftc8inx 1997 10 Background background NN cord-010092-uftc8inx 1997 11 : : : cord-010092-uftc8inx 1997 12 Controlled control VBN cord-010092-uftc8inx 1997 13 non non JJ cord-010092-uftc8inx 1997 14 - - JJ cord-010092-uftc8inx 1997 15 hemato hemato JJ cord-010092-uftc8inx 1997 16 - - HYPH cord-010092-uftc8inx 1997 17 oncological oncological JJ cord-010092-uftc8inx 1997 18 studies study NNS cord-010092-uftc8inx 1997 19 have have VBP cord-010092-uftc8inx 1997 20 consistently consistently RB cord-010092-uftc8inx 1997 21 demonstrated demonstrate VBN cord-010092-uftc8inx 1997 22 a a DT cord-010092-uftc8inx 1997 23 single single JJ cord-010092-uftc8inx 1997 24 - - HYPH cord-010092-uftc8inx 1997 25 unit unit NN cord-010092-uftc8inx 1997 26 red red JJ cord-010092-uftc8inx 1997 27 blood blood NN cord-010092-uftc8inx 1997 28 cell cell NN cord-010092-uftc8inx 1997 29 ( ( -LRB- cord-010092-uftc8inx 1997 30 RBC RBC NNP cord-010092-uftc8inx 1997 31 ) ) -RRB- cord-010092-uftc8inx 1997 32 transfusion transfusion NN cord-010092-uftc8inx 1997 33 policy policy NN cord-010092-uftc8inx 1997 34 as as RB cord-010092-uftc8inx 1997 35 well well RB cord-010092-uftc8inx 1997 36 as as IN cord-010092-uftc8inx 1997 37 a a DT cord-010092-uftc8inx 1997 38 stringent stringent JJ cord-010092-uftc8inx 1997 39 hemoglobin hemoglobin NN cord-010092-uftc8inx 1997 40 ( ( -LRB- cord-010092-uftc8inx 1997 41 Hb Hb NNP cord-010092-uftc8inx 1997 42 ) ) -RRB- cord-010092-uftc8inx 1997 43 RBC RBC NNP cord-010092-uftc8inx 1997 44 transfusion transfusion NN cord-010092-uftc8inx 1997 45 threshold threshold NN cord-010092-uftc8inx 1997 46 to to TO cord-010092-uftc8inx 1997 47 be be VB cord-010092-uftc8inx 1997 48 safe safe JJ cord-010092-uftc8inx 1997 49 and and CC cord-010092-uftc8inx 1997 50 reduce reduce VB cord-010092-uftc8inx 1997 51 blood blood NN cord-010092-uftc8inx 1997 52 product product NN cord-010092-uftc8inx 1997 53 utilization utilization NN cord-010092-uftc8inx 1997 54 . . . cord-010092-uftc8inx 1998 1 Yet yet CC cord-010092-uftc8inx 1998 2 , , , cord-010092-uftc8inx 1998 3 it -PRON- PRP cord-010092-uftc8inx 1998 4 is be VBZ cord-010092-uftc8inx 1998 5 unclear unclear JJ cord-010092-uftc8inx 1998 6 whether whether IN cord-010092-uftc8inx 1998 7 these these DT cord-010092-uftc8inx 1998 8 conclusions conclusion NNS cord-010092-uftc8inx 1998 9 also also RB cord-010092-uftc8inx 1998 10 apply apply VBP cord-010092-uftc8inx 1998 11 to to IN cord-010092-uftc8inx 1998 12 the the DT cord-010092-uftc8inx 1998 13 hemato hemato JJ cord-010092-uftc8inx 1998 14 - - HYPH cord-010092-uftc8inx 1998 15 oncological oncological JJ cord-010092-uftc8inx 1998 16 patient patient NN cord-010092-uftc8inx 1998 17 population population NN cord-010092-uftc8inx 1998 18 . . . cord-010092-uftc8inx 1999 1 Aims aim VBZ cord-010092-uftc8inx 1999 2 : : : cord-010092-uftc8inx 1999 3 To to TO cord-010092-uftc8inx 1999 4 quantify quantify VB cord-010092-uftc8inx 1999 5 reduction reduction NN cord-010092-uftc8inx 1999 6 of of IN cord-010092-uftc8inx 1999 7 RBC RBC NNP cord-010092-uftc8inx 1999 8 blood blood NN cord-010092-uftc8inx 1999 9 product product NN cord-010092-uftc8inx 1999 10 utilization utilization NN cord-010092-uftc8inx 1999 11 by by IN cord-010092-uftc8inx 1999 12 the the DT cord-010092-uftc8inx 1999 13 introduction introduction NN cord-010092-uftc8inx 1999 14 of of IN cord-010092-uftc8inx 1999 15 a a DT cord-010092-uftc8inx 1999 16 restrictive restrictive JJ cord-010092-uftc8inx 1999 17 single single JJ cord-010092-uftc8inx 1999 18 - - HYPH cord-010092-uftc8inx 1999 19 unit unit NN cord-010092-uftc8inx 1999 20 Hb Hb NNP cord-010092-uftc8inx 1999 21 - - HYPH cord-010092-uftc8inx 1999 22 triggered trigger VBD cord-010092-uftc8inx 1999 23 RBC RBC NNP cord-010092-uftc8inx 1999 24 transfusion transfusion NN cord-010092-uftc8inx 1999 25 policy policy NN cord-010092-uftc8inx 1999 26 among among IN cord-010092-uftc8inx 1999 27 the the DT cord-010092-uftc8inx 1999 28 inpatient inpatient JJ cord-010092-uftc8inx 1999 29 hemato hemato JJ cord-010092-uftc8inx 1999 30 - - HYPH cord-010092-uftc8inx 1999 31 oncological oncological JJ cord-010092-uftc8inx 1999 32 population population NN cord-010092-uftc8inx 1999 33 . . . cord-010092-uftc8inx 2000 1 Methods method NNS cord-010092-uftc8inx 2000 2 : : : cord-010092-uftc8inx 2000 3 Under under IN cord-010092-uftc8inx 2000 4 the the DT cord-010092-uftc8inx 2000 5 liberal liberal JJ cord-010092-uftc8inx 2000 6 transfusion transfusion NN cord-010092-uftc8inx 2000 7 protocol protocol NN cord-010092-uftc8inx 2000 8 , , , cord-010092-uftc8inx 2000 9 applied apply VBD cord-010092-uftc8inx 2000 10 up up RP cord-010092-uftc8inx 2000 11 till till IN cord-010092-uftc8inx 2000 12 November November NNP cord-010092-uftc8inx 2000 13 1 1 CD cord-010092-uftc8inx 2000 14 , , , cord-010092-uftc8inx 2000 15 2017 2017 CD cord-010092-uftc8inx 2000 16 , , , cord-010092-uftc8inx 2000 17 standard standard JJ cord-010092-uftc8inx 2000 18 double double JJ cord-010092-uftc8inx 2000 19 - - HYPH cord-010092-uftc8inx 2000 20 unit unit NN cord-010092-uftc8inx 2000 21 RBC RBC NNP cord-010092-uftc8inx 2000 22 transfusion transfusion NN cord-010092-uftc8inx 2000 23 was be VBD cord-010092-uftc8inx 2000 24 indicated indicate VBN cord-010092-uftc8inx 2000 25 with with IN cord-010092-uftc8inx 2000 26 a a DT cord-010092-uftc8inx 2000 27 Hb Hb NNP cord-010092-uftc8inx 2000 28 threshold threshold NN cord-010092-uftc8inx 2000 29 ≤ ≤ NNP cord-010092-uftc8inx 2000 30 8.1 8.1 CD cord-010092-uftc8inx 2000 31 g g NN cord-010092-uftc8inx 2000 32 / / SYM cord-010092-uftc8inx 2000 33 dl dl NN cord-010092-uftc8inx 2000 34 and/or and/or CC cord-010092-uftc8inx 2000 35 anemia anemia NN cord-010092-uftc8inx 2000 36 - - HYPH cord-010092-uftc8inx 2000 37 related relate VBN cord-010092-uftc8inx 2000 38 symptoms symptom NNS cord-010092-uftc8inx 2000 39 . . . cord-010092-uftc8inx 2001 1 Following follow VBG cord-010092-uftc8inx 2001 2 this this DT cord-010092-uftc8inx 2001 3 date date NN cord-010092-uftc8inx 2001 4 , , , cord-010092-uftc8inx 2001 5 the the DT cord-010092-uftc8inx 2001 6 restrictive restrictive JJ cord-010092-uftc8inx 2001 7 transfusion transfusion NN cord-010092-uftc8inx 2001 8 protocol protocol NN cord-010092-uftc8inx 2001 9 was be VBD cord-010092-uftc8inx 2001 10 introduced introduce VBN cord-010092-uftc8inx 2001 11 involving involve VBG cord-010092-uftc8inx 2001 12 a a DT cord-010092-uftc8inx 2001 13 lowering lowering NN cord-010092-uftc8inx 2001 14 of of IN cord-010092-uftc8inx 2001 15 threshold threshold NN cord-010092-uftc8inx 2001 16 to to IN cord-010092-uftc8inx 2001 17 7.3 7.3 CD cord-010092-uftc8inx 2001 18 g g NN cord-010092-uftc8inx 2001 19 / / SYM cord-010092-uftc8inx 2001 20 dl dl NN cord-010092-uftc8inx 2001 21 and and CC cord-010092-uftc8inx 2001 22 single single JJ cord-010092-uftc8inx 2001 23 - - HYPH cord-010092-uftc8inx 2001 24 unit unit NN cord-010092-uftc8inx 2001 25 transfusion transfusion NN cord-010092-uftc8inx 2001 26 . . . cord-010092-uftc8inx 2002 1 For for IN cord-010092-uftc8inx 2002 2 patients patient NNS cord-010092-uftc8inx 2002 3 with with IN cord-010092-uftc8inx 2002 4 an an DT cord-010092-uftc8inx 2002 5 ASA ASA NNP cord-010092-uftc8inx 2002 6 - - HYPH cord-010092-uftc8inx 2002 7 score score NN cord-010092-uftc8inx 2002 8 of of IN cord-010092-uftc8inx 2002 9 II II NNP cord-010092-uftc8inx 2002 10 - - HYPH cord-010092-uftc8inx 2002 11 III III NNP cord-010092-uftc8inx 2002 12 and and CC cord-010092-uftc8inx 2002 13 IV IV NNP cord-010092-uftc8inx 2002 14 , , , cord-010092-uftc8inx 2002 15 a a DT cord-010092-uftc8inx 2002 16 Hb Hb NNP cord-010092-uftc8inx 2002 17 threshold threshold NN cord-010092-uftc8inx 2002 18 of of IN cord-010092-uftc8inx 2002 19 respectively respectively RB cord-010092-uftc8inx 2002 20 ≤ ≤ NNP cord-010092-uftc8inx 2002 21 8.1 8.1 CD cord-010092-uftc8inx 2002 22 g g NN cord-010092-uftc8inx 2002 23 / / SYM cord-010092-uftc8inx 2002 24 dl dl NNP cord-010092-uftc8inx 2002 25 and and CC cord-010092-uftc8inx 2002 26 ≤ ≤ NNP cord-010092-uftc8inx 2002 27 9.7 9.7 CD cord-010092-uftc8inx 2002 28 g g NNP cord-010092-uftc8inx 2002 29 / / SYM cord-010092-uftc8inx 2002 30 dl dl NNP cord-010092-uftc8inx 2002 31 applied apply VBD cord-010092-uftc8inx 2002 32 . . . cord-010092-uftc8inx 2003 1 We -PRON- PRP cord-010092-uftc8inx 2003 2 evaluated evaluate VBD cord-010092-uftc8inx 2003 3 RBC RBC NNP cord-010092-uftc8inx 2003 4 blood blood NN cord-010092-uftc8inx 2003 5 product product NN cord-010092-uftc8inx 2003 6 utilization utilization NN cord-010092-uftc8inx 2003 7 over over IN cord-010092-uftc8inx 2003 8 a a DT cord-010092-uftc8inx 2003 9 6 6 CD cord-010092-uftc8inx 2003 10 month month NN cord-010092-uftc8inx 2003 11 period period NN cord-010092-uftc8inx 2003 12 starting start VBG cord-010092-uftc8inx 2003 13 December December NNP cord-010092-uftc8inx 2003 14 1 1 CD cord-010092-uftc8inx 2003 15 , , , cord-010092-uftc8inx 2003 16 2016 2016 CD cord-010092-uftc8inx 2003 17 ( ( -LRB- cord-010092-uftc8inx 2003 18 liberal liberal JJ cord-010092-uftc8inx 2003 19 protocol protocol NN cord-010092-uftc8inx 2003 20 ) ) -RRB- cord-010092-uftc8inx 2003 21 and and CC cord-010092-uftc8inx 2003 22 December December NNP cord-010092-uftc8inx 2003 23 1 1 CD cord-010092-uftc8inx 2003 24 , , , cord-010092-uftc8inx 2003 25 2017 2017 CD cord-010092-uftc8inx 2003 26 ( ( -LRB- cord-010092-uftc8inx 2003 27 restrictive restrictive JJ cord-010092-uftc8inx 2003 28 protocol protocol NN cord-010092-uftc8inx 2003 29 ) ) -RRB- cord-010092-uftc8inx 2003 30 in in IN cord-010092-uftc8inx 2003 31 all all DT cord-010092-uftc8inx 2003 32 hemato hemato JJ cord-010092-uftc8inx 2003 33 - - HYPH cord-010092-uftc8inx 2003 34 oncological oncological JJ cord-010092-uftc8inx 2003 35 patients patient NNS cord-010092-uftc8inx 2003 36 admitted admit VBN cord-010092-uftc8inx 2003 37 for for IN cord-010092-uftc8inx 2003 38 chemotherapeutic chemotherapeutic JJ cord-010092-uftc8inx 2003 39 treatment treatment NN cord-010092-uftc8inx 2003 40 including include VBG cord-010092-uftc8inx 2003 41 hematopoietic hematopoietic JJ cord-010092-uftc8inx 2003 42 stem stem NN cord-010092-uftc8inx 2003 43 cell cell NN cord-010092-uftc8inx 2003 44 transplantation transplantation NN cord-010092-uftc8inx 2003 45 ( ( -LRB- cord-010092-uftc8inx 2003 46 HSCT HSCT NNP cord-010092-uftc8inx 2003 47 ) ) -RRB- cord-010092-uftc8inx 2003 48 with with IN cord-010092-uftc8inx 2003 49 an an DT cord-010092-uftc8inx 2003 50 expected expect VBN cord-010092-uftc8inx 2003 51 duration duration NN cord-010092-uftc8inx 2003 52 of of IN cord-010092-uftc8inx 2003 53 neutropenia neutropenia NN cord-010092-uftc8inx 2003 54 of of IN cord-010092-uftc8inx 2003 55 ≥ ≥ CD cord-010092-uftc8inx 2003 56 7 7 CD cord-010092-uftc8inx 2003 57 days day NNS cord-010092-uftc8inx 2003 58 . . . cord-010092-uftc8inx 2004 1 Analysis analysis NN cord-010092-uftc8inx 2004 2 of of IN cord-010092-uftc8inx 2004 3 categorical categorical JJ cord-010092-uftc8inx 2004 4 and and CC cord-010092-uftc8inx 2004 5 continuous continuous JJ cord-010092-uftc8inx 2004 6 data datum NNS cord-010092-uftc8inx 2004 7 was be VBD cord-010092-uftc8inx 2004 8 performed perform VBN cord-010092-uftc8inx 2004 9 using use VBG cord-010092-uftc8inx 2004 10 the the DT cord-010092-uftc8inx 2004 11 chi chi NNP cord-010092-uftc8inx 2004 12 - - HYPH cord-010092-uftc8inx 2004 13 square square NNP cord-010092-uftc8inx 2004 14 and and CC cord-010092-uftc8inx 2004 15 Mann Mann NNP cord-010092-uftc8inx 2004 16 - - HYPH cord-010092-uftc8inx 2004 17 Whitney Whitney NNP cord-010092-uftc8inx 2004 18 test test NN cord-010092-uftc8inx 2004 19 , , , cord-010092-uftc8inx 2004 20 respectively respectively RB cord-010092-uftc8inx 2004 21 . . . cord-010092-uftc8inx 2005 1 Results result NNS cord-010092-uftc8inx 2005 2 : : : cord-010092-uftc8inx 2005 3 During during IN cord-010092-uftc8inx 2005 4 both both DT cord-010092-uftc8inx 2005 5 observational observational JJ cord-010092-uftc8inx 2005 6 periods period NNS cord-010092-uftc8inx 2005 7 , , , cord-010092-uftc8inx 2005 8 137 137 CD cord-010092-uftc8inx 2005 9 patients patient NNS cord-010092-uftc8inx 2005 10 were be VBD cord-010092-uftc8inx 2005 11 admitted admit VBN cord-010092-uftc8inx 2005 12 who who WP cord-010092-uftc8inx 2005 13 in in IN cord-010092-uftc8inx 2005 14 total total NN cord-010092-uftc8inx 2005 15 received receive VBD cord-010092-uftc8inx 2005 16 164 164 CD cord-010092-uftc8inx 2005 17 therapy therapy NN cord-010092-uftc8inx 2005 18 cycles cycle NNS cord-010092-uftc8inx 2005 19 , , , cord-010092-uftc8inx 2005 20 including include VBG cord-010092-uftc8inx 2005 21 56 56 CD cord-010092-uftc8inx 2005 22 acute acute JJ cord-010092-uftc8inx 2005 23 myeloid myeloid NN cord-010092-uftc8inx 2005 24 leukemia leukemia NN cord-010092-uftc8inx 2005 25 ( ( -LRB- cord-010092-uftc8inx 2005 26 AML AML NNP cord-010092-uftc8inx 2005 27 ) ) -RRB- cord-010092-uftc8inx 2005 28 induction induction NN cord-010092-uftc8inx 2005 29 cycles cycle NNS cord-010092-uftc8inx 2005 30 and and CC cord-010092-uftc8inx 2005 31 69 69 CD cord-010092-uftc8inx 2005 32 autologous autologous JJ cord-010092-uftc8inx 2005 33 HSCTs hsct NNS cord-010092-uftc8inx 2005 34 . . . cord-010092-uftc8inx 2006 1 Distribution distribution NN cord-010092-uftc8inx 2006 2 of of IN cord-010092-uftc8inx 2006 3 indications indication NNS cord-010092-uftc8inx 2006 4 of of IN cord-010092-uftc8inx 2006 5 admittance admittance NN cord-010092-uftc8inx 2006 6 , , , cord-010092-uftc8inx 2006 7 median median NN cord-010092-uftc8inx 2006 8 age age NN cord-010092-uftc8inx 2006 9 , , , cord-010092-uftc8inx 2006 10 duration duration NN cord-010092-uftc8inx 2006 11 of of IN cord-010092-uftc8inx 2006 12 hospitalization hospitalization NN cord-010092-uftc8inx 2006 13 and and CC cord-010092-uftc8inx 2006 14 duration duration NN cord-010092-uftc8inx 2006 15 of of IN cord-010092-uftc8inx 2006 16 neutropenia neutropenia NN cord-010092-uftc8inx 2006 17 did do VBD cord-010092-uftc8inx 2006 18 not not RB cord-010092-uftc8inx 2006 19 differ differ VB cord-010092-uftc8inx 2006 20 between between IN cord-010092-uftc8inx 2006 21 both both DT cord-010092-uftc8inx 2006 22 periods period NNS cord-010092-uftc8inx 2006 23 . . . cord-010092-uftc8inx 2007 1 During during IN cord-010092-uftc8inx 2007 2 the the DT cord-010092-uftc8inx 2007 3 restrictive restrictive JJ cord-010092-uftc8inx 2007 4 period period NN cord-010092-uftc8inx 2007 5 , , , cord-010092-uftc8inx 2007 6 in in IN cord-010092-uftc8inx 2007 7 303/402 303/402 CD cord-010092-uftc8inx 2007 8 ( ( -LRB- cord-010092-uftc8inx 2007 9 75.4 75.4 CD cord-010092-uftc8inx 2007 10 % % NN cord-010092-uftc8inx 2007 11 ) ) -RRB- cord-010092-uftc8inx 2007 12 of of IN cord-010092-uftc8inx 2007 13 transfusions transfusion NNS cord-010092-uftc8inx 2007 14 the the DT cord-010092-uftc8inx 2007 15 assigned assign VBN cord-010092-uftc8inx 2007 16 Hb Hb NNP cord-010092-uftc8inx 2007 17 trigger trigger NN cord-010092-uftc8inx 2007 18 was be VBD cord-010092-uftc8inx 2007 19 adhered adhere VBN cord-010092-uftc8inx 2007 20 to to IN cord-010092-uftc8inx 2007 21 . . . cord-010092-uftc8inx 2008 1 The the DT cord-010092-uftc8inx 2008 2 percentage percentage NN cord-010092-uftc8inx 2008 3 of of IN cord-010092-uftc8inx 2008 4 single single JJ cord-010092-uftc8inx 2008 5 - - HYPH cord-010092-uftc8inx 2008 6 unit unit NN cord-010092-uftc8inx 2008 7 transfusion transfusion NN cord-010092-uftc8inx 2008 8 episodes episode NNS cord-010092-uftc8inx 2008 9 increased increase VBD cord-010092-uftc8inx 2008 10 from from IN cord-010092-uftc8inx 2008 11 29/112 29/112 CD cord-010092-uftc8inx 2008 12 ( ( -LRB- cord-010092-uftc8inx 2008 13 29.0 29.0 CD cord-010092-uftc8inx 2008 14 % % NN cord-010092-uftc8inx 2008 15 ) ) -RRB- cord-010092-uftc8inx 2008 16 to to IN cord-010092-uftc8inx 2008 17 81/111(73.0 81/111(73.0 CD cord-010092-uftc8inx 2008 18 % % NN cord-010092-uftc8inx 2008 19 ) ) -RRB- cord-010092-uftc8inx 2008 20 with with IN cord-010092-uftc8inx 2008 21 the the DT cord-010092-uftc8inx 2008 22 introduction introduction NN cord-010092-uftc8inx 2008 23 of of IN cord-010092-uftc8inx 2008 24 the the DT cord-010092-uftc8inx 2008 25 restrictive restrictive JJ cord-010092-uftc8inx 2008 26 protocol protocol NN cord-010092-uftc8inx 2008 27 . . . cord-010092-uftc8inx 2009 1 Overall overall RB cord-010092-uftc8inx 2009 2 , , , cord-010092-uftc8inx 2009 3 RBC RBC NNP cord-010092-uftc8inx 2009 4 blood blood NN cord-010092-uftc8inx 2009 5 product product NN cord-010092-uftc8inx 2009 6 utilization utilization NN cord-010092-uftc8inx 2009 7 per per IN cord-010092-uftc8inx 2009 8 admittance admittance NN cord-010092-uftc8inx 2009 9 did do VBD cord-010092-uftc8inx 2009 10 not not RB cord-010092-uftc8inx 2009 11 reduce reduce VB cord-010092-uftc8inx 2009 12 under under IN cord-010092-uftc8inx 2009 13 the the DT cord-010092-uftc8inx 2009 14 restrictive restrictive JJ cord-010092-uftc8inx 2009 15 protocol protocol NN cord-010092-uftc8inx 2009 16 ( ( -LRB- cord-010092-uftc8inx 2009 17 cumulative cumulative JJ cord-010092-uftc8inx 2009 18 number number NN cord-010092-uftc8inx 2009 19 of of IN cord-010092-uftc8inx 2009 20 transfused transfuse VBN cord-010092-uftc8inx 2009 21 RBC RBC NNP cord-010092-uftc8inx 2009 22 units unit NNS cord-010092-uftc8inx 2009 23 4.0 4.0 CD cord-010092-uftc8inx 2009 24 ( ( -LRB- cord-010092-uftc8inx 2009 25 interquartile interquartile JJ cord-010092-uftc8inx 2009 26 range range NN cord-010092-uftc8inx 2009 27 ( ( -LRB- cord-010092-uftc8inx 2009 28 IQR IQR NNP cord-010092-uftc8inx 2009 29 ) ) -RRB- cord-010092-uftc8inx 2009 30 2.0 2.0 CD cord-010092-uftc8inx 2009 31 - - SYM cord-010092-uftc8inx 2009 32 8.0 8.0 CD cord-010092-uftc8inx 2009 33 ) ) -RRB- cord-010092-uftc8inx 2009 34 during during IN cord-010092-uftc8inx 2009 35 the the DT cord-010092-uftc8inx 2009 36 liberal liberal JJ cord-010092-uftc8inx 2009 37 versus versus IN cord-010092-uftc8inx 2009 38 2.5 2.5 CD cord-010092-uftc8inx 2009 39 ( ( -LRB- cord-010092-uftc8inx 2009 40 IQR IQR NNP cord-010092-uftc8inx 2009 41 0.0 0.0 CD cord-010092-uftc8inx 2009 42 - - HYPH cord-010092-uftc8inx 2009 43 9.0 9.0 CD cord-010092-uftc8inx 2009 44 ) ) -RRB- cord-010092-uftc8inx 2009 45 during during IN cord-010092-uftc8inx 2009 46 the the DT cord-010092-uftc8inx 2009 47 restrictive restrictive JJ cord-010092-uftc8inx 2009 48 period period NN cord-010092-uftc8inx 2009 49 ( ( -LRB- cord-010092-uftc8inx 2009 50 P p NN cord-010092-uftc8inx 2009 51 = = SYM cord-010092-uftc8inx 2009 52 0.36 0.36 CD cord-010092-uftc8inx 2009 53 ) ) -RRB- cord-010092-uftc8inx 2009 54 ) ) -RRB- cord-010092-uftc8inx 2009 55 . . . cord-010092-uftc8inx 2010 1 However however RB cord-010092-uftc8inx 2010 2 , , , cord-010092-uftc8inx 2010 3 RBC RBC NNP cord-010092-uftc8inx 2010 4 blood blood NN cord-010092-uftc8inx 2010 5 product product NN cord-010092-uftc8inx 2010 6 utilization utilization NN cord-010092-uftc8inx 2010 7 per per IN cord-010092-uftc8inx 2010 8 neutropenic neutropenic JJ cord-010092-uftc8inx 2010 9 day day NN cord-010092-uftc8inx 2010 10 demonstrated demonstrate VBD cord-010092-uftc8inx 2010 11 a a DT cord-010092-uftc8inx 2010 12 trend trend NN cord-010092-uftc8inx 2010 13 towards towards IN cord-010092-uftc8inx 2010 14 reduction reduction NN cord-010092-uftc8inx 2010 15 : : : cord-010092-uftc8inx 2010 16 0.25 0.25 CD cord-010092-uftc8inx 2010 17 ( ( -LRB- cord-010092-uftc8inx 2010 18 IQR IQR NNP cord-010092-uftc8inx 2010 19 0.11 0.11 CD cord-010092-uftc8inx 2010 20 - - HYPH cord-010092-uftc8inx 2010 21 0.33 0.33 CD cord-010092-uftc8inx 2010 22 ) ) -RRB- cord-010092-uftc8inx 2010 23 versus versus IN cord-010092-uftc8inx 2010 24 0.15 0.15 CD cord-010092-uftc8inx 2011 1 ( ( -LRB- cord-010092-uftc8inx 2011 2 IQR IQR NNP cord-010092-uftc8inx 2011 3 0.00 0.00 CD cord-010092-uftc8inx 2011 4 - - HYPH cord-010092-uftc8inx 2011 5 0.32 0.32 CD cord-010092-uftc8inx 2011 6 ) ) -RRB- cord-010092-uftc8inx 2011 7 units unit NNS cord-010092-uftc8inx 2011 8 per per IN cord-010092-uftc8inx 2011 9 day day NN cord-010092-uftc8inx 2011 10 during during IN cord-010092-uftc8inx 2011 11 the the DT cord-010092-uftc8inx 2011 12 liberal liberal JJ cord-010092-uftc8inx 2011 13 versus versus IN cord-010092-uftc8inx 2011 14 restrictive restrictive JJ cord-010092-uftc8inx 2011 15 period period NN cord-010092-uftc8inx 2011 16 , , , cord-010092-uftc8inx 2011 17 respectively respectively RB cord-010092-uftc8inx 2011 18 ( ( -LRB- cord-010092-uftc8inx 2011 19 P p NN cord-010092-uftc8inx 2011 20 = = SYM cord-010092-uftc8inx 2011 21 0.06 0.06 CD cord-010092-uftc8inx 2011 22 ) ) -RRB- cord-010092-uftc8inx 2011 23 . . . cord-010092-uftc8inx 2012 1 This this DT cord-010092-uftc8inx 2012 2 reduction reduction NN cord-010092-uftc8inx 2012 3 was be VBD cord-010092-uftc8inx 2012 4 mainly mainly RB cord-010092-uftc8inx 2012 5 attributed attribute VBN cord-010092-uftc8inx 2012 6 to to IN cord-010092-uftc8inx 2012 7 autologous autologous JJ cord-010092-uftc8inx 2012 8 HSCTs hsct NNS cord-010092-uftc8inx 2012 9 during during IN cord-010092-uftc8inx 2012 10 which which WDT cord-010092-uftc8inx 2012 11 RBC RBC NNP cord-010092-uftc8inx 2012 12 blood blood NN cord-010092-uftc8inx 2012 13 product product NN cord-010092-uftc8inx 2012 14 utilization utilization NN cord-010092-uftc8inx 2012 15 decreased decrease VBD cord-010092-uftc8inx 2012 16 from from IN cord-010092-uftc8inx 2012 17 2.0 2.0 CD cord-010092-uftc8inx 2012 18 ( ( -LRB- cord-010092-uftc8inx 2012 19 IQR IQR NNP cord-010092-uftc8inx 2012 20 0.0 0.0 CD cord-010092-uftc8inx 2012 21 - - SYM cord-010092-uftc8inx 2012 22 2.0 2.0 CD cord-010092-uftc8inx 2012 23 ) ) -RRB- cord-010092-uftc8inx 2012 24 to to IN cord-010092-uftc8inx 2012 25 0.0 0.0 CD cord-010092-uftc8inx 2012 26 ( ( -LRB- cord-010092-uftc8inx 2012 27 IQR IQR NNP cord-010092-uftc8inx 2012 28 0.0 0.0 CD cord-010092-uftc8inx 2012 29 - - SYM cord-010092-uftc8inx 2012 30 1.5 1.5 CD cord-010092-uftc8inx 2012 31 ) ) -RRB- cord-010092-uftc8inx 2012 32 units unit NNS cord-010092-uftc8inx 2012 33 ( ( -LRB- cord-010092-uftc8inx 2012 34 P p NN cord-010092-uftc8inx 2012 35 = = SYM cord-010092-uftc8inx 2012 36 0.06 0.06 CD cord-010092-uftc8inx 2012 37 ) ) -RRB- cord-010092-uftc8inx 2012 38 , , , cord-010092-uftc8inx 2012 39 corresponding correspond VBG cord-010092-uftc8inx 2012 40 to to IN cord-010092-uftc8inx 2012 41 a a DT cord-010092-uftc8inx 2012 42 reduction reduction NN cord-010092-uftc8inx 2012 43 from from IN cord-010092-uftc8inx 2012 44 0.13 0.13 CD cord-010092-uftc8inx 2012 45 ( ( -LRB- cord-010092-uftc8inx 2012 46 IQR IQR NNP cord-010092-uftc8inx 2012 47 0.00 0.00 CD cord-010092-uftc8inx 2012 48 - - HYPH cord-010092-uftc8inx 2012 49 0.21 0.21 CD cord-010092-uftc8inx 2012 50 ) ) -RRB- cord-010092-uftc8inx 2012 51 to to IN cord-010092-uftc8inx 2012 52 0.0 0.0 CD cord-010092-uftc8inx 2012 53 ( ( -LRB- cord-010092-uftc8inx 2012 54 IQR IQR NNP cord-010092-uftc8inx 2012 55 0.0 0.0 CD cord-010092-uftc8inx 2012 56 - - HYPH cord-010092-uftc8inx 2012 57 0.13 0.13 CD cord-010092-uftc8inx 2012 58 ) ) -RRB- cord-010092-uftc8inx 2012 59 ( ( -LRB- cord-010092-uftc8inx 2012 60 P p NN cord-010092-uftc8inx 2012 61 = = SYM cord-010092-uftc8inx 2012 62 0.01 0.01 CD cord-010092-uftc8inx 2012 63 ) ) -RRB- cord-010092-uftc8inx 2012 64 units unit NNS cord-010092-uftc8inx 2012 65 per per IN cord-010092-uftc8inx 2012 66 neutropenic neutropenic JJ cord-010092-uftc8inx 2012 67 day day NN cord-010092-uftc8inx 2012 68 . . . cord-010092-uftc8inx 2013 1 Moreover moreover RB cord-010092-uftc8inx 2013 2 , , , cord-010092-uftc8inx 2013 3 14/38 14/38 CD cord-010092-uftc8inx 2013 4 ( ( -LRB- cord-010092-uftc8inx 2013 5 36.8 36.8 CD cord-010092-uftc8inx 2013 6 % % NN cord-010092-uftc8inx 2013 7 ) ) -RRB- cord-010092-uftc8inx 2013 8 patients patient NNS cord-010092-uftc8inx 2013 9 during during IN cord-010092-uftc8inx 2013 10 the the DT cord-010092-uftc8inx 2013 11 liberal liberal JJ cord-010092-uftc8inx 2013 12 versus versus IN cord-010092-uftc8inx 2013 13 21/31 21/31 CD cord-010092-uftc8inx 2013 14 ( ( -LRB- cord-010092-uftc8inx 2013 15 67.7 67.7 CD cord-010092-uftc8inx 2013 16 % % NN cord-010092-uftc8inx 2013 17 ) ) -RRB- cord-010092-uftc8inx 2013 18 during during IN cord-010092-uftc8inx 2013 19 the the DT cord-010092-uftc8inx 2013 20 restrictive restrictive JJ cord-010092-uftc8inx 2013 21 period period NN cord-010092-uftc8inx 2013 22 did do VBD cord-010092-uftc8inx 2013 23 not not RB cord-010092-uftc8inx 2013 24 require require VB cord-010092-uftc8inx 2013 25 RBC RBC NNP cord-010092-uftc8inx 2013 26 transfusion transfusion NN cord-010092-uftc8inx 2013 27 during during IN cord-010092-uftc8inx 2013 28 admittance admittance NN cord-010092-uftc8inx 2013 29 . . . cord-010092-uftc8inx 2014 1 Consequently consequently RB cord-010092-uftc8inx 2014 2 , , , cord-010092-uftc8inx 2014 3 stringent stringent JJ cord-010092-uftc8inx 2014 4 Hb Hb NNP cord-010092-uftc8inx 2014 5 thresholds threshold NNS cord-010092-uftc8inx 2014 6 as as IN cord-010092-uftc8inx 2014 7 compared compare VBN cord-010092-uftc8inx 2014 8 to to IN cord-010092-uftc8inx 2014 9 single single JJ cord-010092-uftc8inx 2014 10 - - HYPH cord-010092-uftc8inx 2014 11 unit unit NN cord-010092-uftc8inx 2014 12 transfusions transfusion NNS cord-010092-uftc8inx 2014 13 seem seem VBP cord-010092-uftc8inx 2014 14 to to TO cord-010092-uftc8inx 2014 15 more more RBR cord-010092-uftc8inx 2014 16 strongly strongly RB cord-010092-uftc8inx 2014 17 impact impact VB cord-010092-uftc8inx 2014 18 RBC RBC NNP cord-010092-uftc8inx 2014 19 blood blood NN cord-010092-uftc8inx 2014 20 product product NN cord-010092-uftc8inx 2014 21 utilization utilization NN cord-010092-uftc8inx 2014 22 . . . cord-010092-uftc8inx 2015 1 Summary Summary NNP cord-010092-uftc8inx 2015 2 / / SYM cord-010092-uftc8inx 2015 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 2015 4 : : : cord-010092-uftc8inx 2016 1 A a DT cord-010092-uftc8inx 2016 2 Hb Hb NNP cord-010092-uftc8inx 2016 3 - - HYPH cord-010092-uftc8inx 2016 4 triggered trigger VBN cord-010092-uftc8inx 2016 5 single single JJ cord-010092-uftc8inx 2016 6 - - HYPH cord-010092-uftc8inx 2016 7 unit unit NN cord-010092-uftc8inx 2016 8 transfusion transfusion NN cord-010092-uftc8inx 2016 9 policy policy NN cord-010092-uftc8inx 2016 10 results result NNS cord-010092-uftc8inx 2016 11 in in IN cord-010092-uftc8inx 2016 12 a a DT cord-010092-uftc8inx 2016 13 strong strong JJ cord-010092-uftc8inx 2016 14 reduction reduction NN cord-010092-uftc8inx 2016 15 of of IN cord-010092-uftc8inx 2016 16 RBC RBC NNP cord-010092-uftc8inx 2016 17 blood blood NN cord-010092-uftc8inx 2016 18 product product NN cord-010092-uftc8inx 2016 19 utilization utilization NN cord-010092-uftc8inx 2016 20 in in IN cord-010092-uftc8inx 2016 21 the the DT cord-010092-uftc8inx 2016 22 setting setting NN cord-010092-uftc8inx 2016 23 of of IN cord-010092-uftc8inx 2016 24 autologous autologous JJ cord-010092-uftc8inx 2016 25 HSCT HSCT NNP cord-010092-uftc8inx 2016 26 . . . cord-010092-uftc8inx 2017 1 No no DT cord-010092-uftc8inx 2017 2 utilization utilization NN cord-010092-uftc8inx 2017 3 reduction reduction NN cord-010092-uftc8inx 2017 4 was be VBD cord-010092-uftc8inx 2017 5 observed observe VBN cord-010092-uftc8inx 2017 6 among among IN cord-010092-uftc8inx 2017 7 other other JJ cord-010092-uftc8inx 2017 8 hemato hemato JJ cord-010092-uftc8inx 2017 9 - - HYPH cord-010092-uftc8inx 2017 10 oncological oncological JJ cord-010092-uftc8inx 2017 11 inpatient inpatient JJ cord-010092-uftc8inx 2017 12 populations population NNS cord-010092-uftc8inx 2017 13 receiving receive VBG cord-010092-uftc8inx 2017 14 intensive intensive JJ cord-010092-uftc8inx 2017 15 chemotherapy chemotherapy NN cord-010092-uftc8inx 2017 16 . . . cord-010092-uftc8inx 2018 1 Further further JJ cord-010092-uftc8inx 2018 2 improvement improvement NN cord-010092-uftc8inx 2018 3 of of IN cord-010092-uftc8inx 2018 4 protocol protocol NN cord-010092-uftc8inx 2018 5 adherence adherence NN cord-010092-uftc8inx 2018 6 rates rate NNS cord-010092-uftc8inx 2018 7 could could MD cord-010092-uftc8inx 2018 8 potentially potentially RB cord-010092-uftc8inx 2018 9 increase increase VB cord-010092-uftc8inx 2018 10 the the DT cord-010092-uftc8inx 2018 11 benefit benefit NN cord-010092-uftc8inx 2018 12 of of IN cord-010092-uftc8inx 2018 13 this this DT cord-010092-uftc8inx 2018 14 blood blood NN cord-010092-uftc8inx 2018 15 saving saving NN cord-010092-uftc8inx 2018 16 strategy strategy NN cord-010092-uftc8inx 2018 17 . . . cord-010092-uftc8inx 2019 1 4A 4a LS cord-010092-uftc8inx 2019 2 - - : cord-010092-uftc8inx 2019 3 S17 S17 NNP cord-010092-uftc8inx 2019 4 - - HYPH cord-010092-uftc8inx 2019 5 04 04 CD cord-010092-uftc8inx 2019 6 ASSESSMENT ASSESSMENT NNP cord-010092-uftc8inx 2019 7 OF of IN cord-010092-uftc8inx 2019 8 HB HB NNP cord-010092-uftc8inx 2019 9 CONTENT content RB cord-010092-uftc8inx 2019 10 OF of IN cord-010092-uftc8inx 2019 11 PACKED packed JJ cord-010092-uftc8inx 2019 12 RED red JJ cord-010092-uftc8inx 2019 13 CELLS cell NNS cord-010092-uftc8inx 2019 14 ( ( -LRB- cord-010092-uftc8inx 2019 15 PRBC PRBC NNP cord-010092-uftc8inx 2019 16 ) ) -RRB- cord-010092-uftc8inx 2020 1 : : : cord-010092-uftc8inx 2020 2 IS be VBZ cord-010092-uftc8inx 2020 3 IT IT NNP cord-010092-uftc8inx 2020 4 TIME time NN cord-010092-uftc8inx 2020 5 TO to TO cord-010092-uftc8inx 2020 6 LABEL label VB cord-010092-uftc8inx 2020 7 EACH each DT cord-010092-uftc8inx 2020 8 UNIT unit NN cord-010092-uftc8inx 2020 9 WITH with IN cord-010092-uftc8inx 2020 10 HB HB NNP cord-010092-uftc8inx 2020 11 _SP cord-010092-uftc8inx 2020 12 CONTENT CONTENT NNP cord-010092-uftc8inx 2020 13 ? ? . cord-010092-uftc8inx 2021 1 R R NNP cord-010092-uftc8inx 2021 2 Jain Jain NNP cord-010092-uftc8inx 2021 3 1 1 CD cord-010092-uftc8inx 2021 4 , , , cord-010092-uftc8inx 2021 5 N N NNP cord-010092-uftc8inx 2021 6 Marwaha Marwaha NNP cord-010092-uftc8inx 2021 7 2 2 CD cord-010092-uftc8inx 2021 8 and and CC cord-010092-uftc8inx 2021 9 S s NN cord-010092-uftc8inx 2021 10 Sachdev Sachdev NNS cord-010092-uftc8inx 2022 1 2 2 CD cord-010092-uftc8inx 2022 2 1 1 CD cord-010092-uftc8inx 2022 3 Transfusion Transfusion NNP cord-010092-uftc8inx 2022 4 Medicine Medicine NNP cord-010092-uftc8inx 2022 5 , , , cord-010092-uftc8inx 2022 6 Aiims Aiims NNP cord-010092-uftc8inx 2022 7 , , , cord-010092-uftc8inx 2022 8 New New NNP cord-010092-uftc8inx 2022 9 Delhi Delhi NNP cord-010092-uftc8inx 2022 10 2 2 CD cord-010092-uftc8inx 2022 11 Transfusion Transfusion NNP cord-010092-uftc8inx 2022 12 Medicine Medicine NNP cord-010092-uftc8inx 2022 13 , , , cord-010092-uftc8inx 2022 14 Pgimer Pgimer NNP cord-010092-uftc8inx 2022 15 , , , cord-010092-uftc8inx 2022 16 Chandigarh Chandigarh NNP cord-010092-uftc8inx 2022 17 , , , cord-010092-uftc8inx 2023 1 India India NNP cord-010092-uftc8inx 2023 2 Background Background NNP cord-010092-uftc8inx 2023 3 : : : cord-010092-uftc8inx 2024 1 In in IN cord-010092-uftc8inx 2024 2 the the DT cord-010092-uftc8inx 2024 3 current current JJ cord-010092-uftc8inx 2024 4 era era NN cord-010092-uftc8inx 2024 5 of of IN cord-010092-uftc8inx 2024 6 evidence evidence NN cord-010092-uftc8inx 2024 7 based base VBN cord-010092-uftc8inx 2024 8 medicine medicine NN cord-010092-uftc8inx 2024 9 and and CC cord-010092-uftc8inx 2024 10 individualized individualized JJ cord-010092-uftc8inx 2024 11 care care NN cord-010092-uftc8inx 2024 12 of of IN cord-010092-uftc8inx 2024 13 patients patient NNS cord-010092-uftc8inx 2024 14 , , , cord-010092-uftc8inx 2024 15 RBC RBC NNP cord-010092-uftc8inx 2024 16 transfusion transfusion NN cord-010092-uftc8inx 2024 17 continues continue VBZ cord-010092-uftc8inx 2024 18 to to TO cord-010092-uftc8inx 2024 19 be be VB cord-010092-uftc8inx 2024 20 administered administer VBN cord-010092-uftc8inx 2024 21 on on IN cord-010092-uftc8inx 2024 22 the the DT cord-010092-uftc8inx 2024 23 basis basis NN cord-010092-uftc8inx 2024 24 of of IN cord-010092-uftc8inx 2024 25 conventional conventional JJ cord-010092-uftc8inx 2024 26 wisdom wisdom NN cord-010092-uftc8inx 2024 27 and and CC cord-010092-uftc8inx 2024 28 the the DT cord-010092-uftc8inx 2024 29 notion notion NN cord-010092-uftc8inx 2024 30 of of IN cord-010092-uftc8inx 2024 31 an an DT cord-010092-uftc8inx 2024 32 average average JJ cord-010092-uftc8inx 2024 33 benefit benefit NN cord-010092-uftc8inx 2024 34 per per IN cord-010092-uftc8inx 2024 35 unit unit NN cord-010092-uftc8inx 2024 36 . . . cord-010092-uftc8inx 2025 1 The the DT cord-010092-uftc8inx 2025 2 existing exist VBG cord-010092-uftc8inx 2025 3 blood blood NN cord-010092-uftc8inx 2025 4 transfusion transfusion NN cord-010092-uftc8inx 2025 5 practice practice NN cord-010092-uftc8inx 2025 6 based base VBN cord-010092-uftc8inx 2025 7 on on IN cord-010092-uftc8inx 2025 8 the the DT cord-010092-uftc8inx 2025 9 " " `` cord-010092-uftc8inx 2025 10 number number NN cord-010092-uftc8inx 2025 11 of of IN cord-010092-uftc8inx 2025 12 units unit NNS cord-010092-uftc8inx 2025 13 transfused transfuse VBN cord-010092-uftc8inx 2025 14 " " '' cord-010092-uftc8inx 2025 15 ignores ignore VBZ cord-010092-uftc8inx 2025 16 the the DT cord-010092-uftc8inx 2025 17 fact fact NN cord-010092-uftc8inx 2025 18 that that IN cord-010092-uftc8inx 2025 19 the the DT cord-010092-uftc8inx 2025 20 total total JJ cord-010092-uftc8inx 2025 21 Hb Hb NNP cord-010092-uftc8inx 2025 22 varies vary VBZ cord-010092-uftc8inx 2025 23 markedly markedly RB cord-010092-uftc8inx 2025 24 among among IN cord-010092-uftc8inx 2025 25 the the DT cord-010092-uftc8inx 2025 26 individual individual JJ cord-010092-uftc8inx 2025 27 RBC RBC NNP cord-010092-uftc8inx 2025 28 units unit NNS cord-010092-uftc8inx 2025 29 . . . cord-010092-uftc8inx 2026 1 Aims aim VBZ cord-010092-uftc8inx 2026 2 : : : cord-010092-uftc8inx 2027 1 The the DT cord-010092-uftc8inx 2027 2 present present JJ cord-010092-uftc8inx 2027 3 study study NN cord-010092-uftc8inx 2027 4 was be VBD cord-010092-uftc8inx 2027 5 aimed aim VBN cord-010092-uftc8inx 2027 6 at at IN cord-010092-uftc8inx 2027 7 estimating estimate VBG cord-010092-uftc8inx 2027 8 the the DT cord-010092-uftc8inx 2027 9 Hb Hb NNP cord-010092-uftc8inx 2027 10 content content NN cord-010092-uftc8inx 2027 11 in in IN cord-010092-uftc8inx 2027 12 packed pack VBN cord-010092-uftc8inx 2027 13 red red JJ cord-010092-uftc8inx 2027 14 cell cell NN cord-010092-uftc8inx 2027 15 unit unit NN cord-010092-uftc8inx 2027 16 prepared prepare VBN cord-010092-uftc8inx 2027 17 by by IN cord-010092-uftc8inx 2027 18 three three CD cord-010092-uftc8inx 2027 19 different different JJ cord-010092-uftc8inx 2027 20 protocols protocol NNS cord-010092-uftc8inx 2027 21 from from IN cord-010092-uftc8inx 2027 22 350 350 CD cord-010092-uftc8inx 2027 23 ml ml NNS cord-010092-uftc8inx 2027 24 and and CC cord-010092-uftc8inx 2027 25 450 450 CD cord-010092-uftc8inx 2027 26 ml ml XX cord-010092-uftc8inx 2027 27 whole whole JJ cord-010092-uftc8inx 2027 28 blood blood NN cord-010092-uftc8inx 2027 29 collection collection NN cord-010092-uftc8inx 2027 30 in in IN cord-010092-uftc8inx 2027 31 three three CD cord-010092-uftc8inx 2027 32 types type NNS cord-010092-uftc8inx 2027 33 of of IN cord-010092-uftc8inx 2027 34 blood blood NN cord-010092-uftc8inx 2027 35 donors donor NNS cord-010092-uftc8inx 2027 36 : : : cord-010092-uftc8inx 2027 37 replacement replacement NN cord-010092-uftc8inx 2027 38 blood blood NN cord-010092-uftc8inx 2027 39 donor donor NN cord-010092-uftc8inx 2027 40 ( ( -LRB- cord-010092-uftc8inx 2027 41 RD RD NNP cord-010092-uftc8inx 2027 42 ) ) -RRB- cord-010092-uftc8inx 2027 43 , , , cord-010092-uftc8inx 2027 44 first first JJ cord-010092-uftc8inx 2027 45 time time NN cord-010092-uftc8inx 2027 46 voluntary voluntary JJ cord-010092-uftc8inx 2027 47 donor donor NN cord-010092-uftc8inx 2027 48 ( ( -LRB- cord-010092-uftc8inx 2027 49 FTVD FTVD NNP cord-010092-uftc8inx 2027 50 ) ) -RRB- cord-010092-uftc8inx 2027 51 and and CC cord-010092-uftc8inx 2027 52 regular regular JJ cord-010092-uftc8inx 2027 53 voluntary voluntary JJ cord-010092-uftc8inx 2027 54 blood blood NN cord-010092-uftc8inx 2027 55 donor donor NN cord-010092-uftc8inx 2027 56 ( ( -LRB- cord-010092-uftc8inx 2027 57 RTVD RTVD NNP cord-010092-uftc8inx 2027 58 ) ) -RRB- cord-010092-uftc8inx 2027 59 . . . cord-010092-uftc8inx 2028 1 Methods method NNS cord-010092-uftc8inx 2028 2 : : : cord-010092-uftc8inx 2029 1 A a DT cord-010092-uftc8inx 2029 2 total total NN cord-010092-uftc8inx 2029 3 of of IN cord-010092-uftc8inx 2029 4 900 900 CD cord-010092-uftc8inx 2029 5 prospective prospective JJ cord-010092-uftc8inx 2029 6 blood blood NN cord-010092-uftc8inx 2029 7 donors donor NNS cord-010092-uftc8inx 2029 8 were be VBD cord-010092-uftc8inx 2029 9 included include VBN cord-010092-uftc8inx 2029 10 in in IN cord-010092-uftc8inx 2029 11 this this DT cord-010092-uftc8inx 2029 12 study study NN cord-010092-uftc8inx 2029 13 . . . cord-010092-uftc8inx 2030 1 Three three CD cord-010092-uftc8inx 2030 2 hundred hundred CD cord-010092-uftc8inx 2030 3 whole whole JJ cord-010092-uftc8inx 2030 4 blood blood NN cord-010092-uftc8inx 2030 5 collections collection NNS cord-010092-uftc8inx 2030 6 were be VBD cord-010092-uftc8inx 2030 7 performed perform VBN cord-010092-uftc8inx 2030 8 in in IN cord-010092-uftc8inx 2030 9 each each DT cord-010092-uftc8inx 2030 10 of of IN cord-010092-uftc8inx 2030 11 the the DT cord-010092-uftc8inx 2030 12 three three CD cord-010092-uftc8inx 2030 13 groups group NNS cord-010092-uftc8inx 2030 14 of of IN cord-010092-uftc8inx 2030 15 donors donor NNS cord-010092-uftc8inx 2030 16 ( ( -LRB- cord-010092-uftc8inx 2030 17 RD RD NNP cord-010092-uftc8inx 2030 18 , , , cord-010092-uftc8inx 2030 19 FTVD FTVD NNP cord-010092-uftc8inx 2030 20 , , , cord-010092-uftc8inx 2030 21 and and CC cord-010092-uftc8inx 2030 22 RTVD RTVD NNP cord-010092-uftc8inx 2030 23 ) ) -RRB- cord-010092-uftc8inx 2030 24 . . . cord-010092-uftc8inx 2031 1 Within within IN cord-010092-uftc8inx 2031 2 each each DT cord-010092-uftc8inx 2031 3 group group NN cord-010092-uftc8inx 2031 4 100 100 CD cord-010092-uftc8inx 2031 5 collections collection NNS cord-010092-uftc8inx 2031 6 were be VBD cord-010092-uftc8inx 2031 7 done do VBN cord-010092-uftc8inx 2031 8 in in IN cord-010092-uftc8inx 2031 9 Double Double NNP cord-010092-uftc8inx 2031 10 350 350 CD cord-010092-uftc8inx 2031 11 ml ml NNS cord-010092-uftc8inx 2031 12 , , , cord-010092-uftc8inx 2031 13 Triple Triple NNP cord-010092-uftc8inx 2031 14 450 450 CD cord-010092-uftc8inx 2031 15 ml ml NNS cord-010092-uftc8inx 2031 16 and and CC cord-010092-uftc8inx 2031 17 Quadruple Quadruple NNP cord-010092-uftc8inx 2031 18 450 450 CD cord-010092-uftc8inx 2031 19 ml ml NN cord-010092-uftc8inx 2031 20 blood blood NN cord-010092-uftc8inx 2031 21 bags bag NNS cord-010092-uftc8inx 2031 22 respectively respectively RB cord-010092-uftc8inx 2031 23 . . . cord-010092-uftc8inx 2032 1 A a DT cord-010092-uftc8inx 2032 2 pre pre JJ cord-010092-uftc8inx 2032 3 - - JJ cord-010092-uftc8inx 2032 4 donation donation NN cord-010092-uftc8inx 2032 5 venous venous JJ cord-010092-uftc8inx 2032 6 sample sample NN cord-010092-uftc8inx 2032 7 was be VBD cord-010092-uftc8inx 2032 8 drawn draw VBN cord-010092-uftc8inx 2032 9 from from IN cord-010092-uftc8inx 2032 10 sample sample NN cord-010092-uftc8inx 2032 11 collection collection NN cord-010092-uftc8inx 2032 12 pouch pouch NN cord-010092-uftc8inx 2032 13 for for IN cord-010092-uftc8inx 2032 14 analysis analysis NN cord-010092-uftc8inx 2032 15 in in IN cord-010092-uftc8inx 2032 16 hematology hematology NN cord-010092-uftc8inx 2032 17 analyzer analyzer NN cord-010092-uftc8inx 2032 18 as as IN cord-010092-uftc8inx 2032 19 reference reference NN cord-010092-uftc8inx 2032 20 method method NN cord-010092-uftc8inx 2032 21 for for IN cord-010092-uftc8inx 2032 22 Hb Hb NNP cord-010092-uftc8inx 2032 23 concentration concentration NN cord-010092-uftc8inx 2032 24 of of IN cord-010092-uftc8inx 2032 25 donor donor NN cord-010092-uftc8inx 2032 26 . . . cord-010092-uftc8inx 2033 1 The the DT cord-010092-uftc8inx 2033 2 Hb Hb NNP cord-010092-uftc8inx 2033 3 content content NN cord-010092-uftc8inx 2033 4 of of IN cord-010092-uftc8inx 2033 5 packed packed JJ cord-010092-uftc8inx 2033 6 red red JJ cord-010092-uftc8inx 2033 7 cell cell NN cord-010092-uftc8inx 2033 8 units unit NNS cord-010092-uftc8inx 2033 9 were be VBD cord-010092-uftc8inx 2033 10 estimated estimate VBN cord-010092-uftc8inx 2033 11 after after IN cord-010092-uftc8inx 2033 12 collection collection NN cord-010092-uftc8inx 2033 13 of of IN cord-010092-uftc8inx 2033 14 representative representative JJ cord-010092-uftc8inx 2033 15 sample sample NN cord-010092-uftc8inx 2033 16 from from IN cord-010092-uftc8inx 2033 17 the the DT cord-010092-uftc8inx 2033 18 blood blood NN cord-010092-uftc8inx 2033 19 unit unit NN cord-010092-uftc8inx 2033 20 . . . cord-010092-uftc8inx 2034 1 Volume volume NN cord-010092-uftc8inx 2034 2 of of IN cord-010092-uftc8inx 2034 3 PRBC PRBC NNP cord-010092-uftc8inx 2034 4 unit unit NN cord-010092-uftc8inx 2034 5 was be VBD cord-010092-uftc8inx 2034 6 estimated estimate VBN cord-010092-uftc8inx 2034 7 by by IN cord-010092-uftc8inx 2034 8 the the DT cord-010092-uftc8inx 2034 9 formula formula NN cord-010092-uftc8inx 2034 10 of of IN cord-010092-uftc8inx 2034 11 weight weight NN cord-010092-uftc8inx 2034 12 of of IN cord-010092-uftc8inx 2034 13 blood blood NN cord-010092-uftc8inx 2034 14 in in IN cord-010092-uftc8inx 2034 15 PRBC PRBC NNP cord-010092-uftc8inx 2034 16 divided divide VBN cord-010092-uftc8inx 2034 17 by by IN cord-010092-uftc8inx 2034 18 specific specific JJ cord-010092-uftc8inx 2034 19 gravity gravity NN cord-010092-uftc8inx 2034 20 . . . cord-010092-uftc8inx 2035 1 The the DT cord-010092-uftc8inx 2035 2 Hb Hb NNP cord-010092-uftc8inx 2035 3 content content NN cord-010092-uftc8inx 2035 4 in in IN cord-010092-uftc8inx 2035 5 unit unit NN cord-010092-uftc8inx 2035 6 was be VBD cord-010092-uftc8inx 2035 7 estimated estimate VBN cord-010092-uftc8inx 2035 8 by by IN cord-010092-uftc8inx 2035 9 the the DT cord-010092-uftc8inx 2035 10 formula formula NN cord-010092-uftc8inx 2035 11 : : : cord-010092-uftc8inx 2035 12 Hb Hb NNP cord-010092-uftc8inx 2035 13 content content NN cord-010092-uftc8inx 2035 14 in in IN cord-010092-uftc8inx 2035 15 unit unit NN cord-010092-uftc8inx 2035 16 = = NFP cord-010092-uftc8inx 2036 1 Hb Hb NNP cord-010092-uftc8inx 2036 2 value value NN cord-010092-uftc8inx 2036 3 of of IN cord-010092-uftc8inx 2036 4 the the DT cord-010092-uftc8inx 2036 5 PRBC PRBC NNP cord-010092-uftc8inx 2036 6 unit unit NN cord-010092-uftc8inx 2036 7 ( ( -LRB- cord-010092-uftc8inx 2036 8 g g NNP cord-010092-uftc8inx 2036 9 / / SYM cord-010092-uftc8inx 2036 10 dl dl NN cord-010092-uftc8inx 2036 11 ) ) -RRB- cord-010092-uftc8inx 2037 1 9 9 CD cord-010092-uftc8inx 2037 2 volume volume NN cord-010092-uftc8inx 2037 3 of of IN cord-010092-uftc8inx 2037 4 PRBC PRBC NNP cord-010092-uftc8inx 2037 5 unit unit NN cord-010092-uftc8inx 2037 6 ( ( -LRB- cord-010092-uftc8inx 2037 7 dl dl NNP cord-010092-uftc8inx 2037 8 ) ) -RRB- cord-010092-uftc8inx 2037 9 . . . cord-010092-uftc8inx 2038 1 Results result NNS cord-010092-uftc8inx 2038 2 : : : cord-010092-uftc8inx 2039 1 In in IN cord-010092-uftc8inx 2039 2 this this DT cord-010092-uftc8inx 2039 3 study study NN cord-010092-uftc8inx 2039 4 the the DT cord-010092-uftc8inx 2039 5 Hb Hb NNP cord-010092-uftc8inx 2039 6 concentration concentration NN cord-010092-uftc8inx 2039 7 ( ( -LRB- cord-010092-uftc8inx 2039 8 g g NNP cord-010092-uftc8inx 2039 9 / / SYM cord-010092-uftc8inx 2039 10 dl dl NN cord-010092-uftc8inx 2039 11 ) ) -RRB- cord-010092-uftc8inx 2039 12 was be VBD cord-010092-uftc8inx 2039 13 comparable comparable JJ cord-010092-uftc8inx 2039 14 among among IN cord-010092-uftc8inx 2039 15 three three CD cord-010092-uftc8inx 2039 16 types type NNS cord-010092-uftc8inx 2039 17 of of IN cord-010092-uftc8inx 2039 18 blood blood NN cord-010092-uftc8inx 2039 19 donors donor NNS cord-010092-uftc8inx 2039 20 except except IN cord-010092-uftc8inx 2039 21 that that DT cord-010092-uftc8inx 2039 22 RTVD RTVD NNP cord-010092-uftc8inx 2039 23 had have VBD cord-010092-uftc8inx 2039 24 lower low JJR cord-010092-uftc8inx 2039 25 Hb Hb NNP cord-010092-uftc8inx 2039 26 values value NNS cord-010092-uftc8inx 2039 27 when when WRB cord-010092-uftc8inx 2039 28 compared compare VBN cord-010092-uftc8inx 2039 29 to to IN cord-010092-uftc8inx 2039 30 RD RD NNP cord-010092-uftc8inx 2039 31 ( ( -LRB- cord-010092-uftc8inx 2039 32 P p NN cord-010092-uftc8inx 2039 33 = = SYM cord-010092-uftc8inx 2039 34 0.007 0.007 CD cord-010092-uftc8inx 2039 35 ) ) -RRB- cord-010092-uftc8inx 2039 36 . . . cord-010092-uftc8inx 2040 1 Hemoglobin hemoglobin NN cord-010092-uftc8inx 2040 2 concentration concentration NN cord-010092-uftc8inx 2040 3 of of IN cord-010092-uftc8inx 2040 4 PRBC PRBC NNP cord-010092-uftc8inx 2040 5 ranged range VBD cord-010092-uftc8inx 2040 6 from from IN cord-010092-uftc8inx 2040 7 14.2 14.2 CD cord-010092-uftc8inx 2040 8 - - HYPH cord-010092-uftc8inx 2040 9 29.6 29.6 CD cord-010092-uftc8inx 2040 10 g g NN cord-010092-uftc8inx 2040 11 / / SYM cord-010092-uftc8inx 2040 12 dl dl NN cord-010092-uftc8inx 2040 13 ; ; : cord-010092-uftc8inx 2040 14 mean mean JJ cord-010092-uftc8inx 2040 15 Hb Hb NNP cord-010092-uftc8inx 2040 16 was be VBD cord-010092-uftc8inx 2040 17 21.02 21.02 CD cord-010092-uftc8inx 2040 18 AE AE NNP cord-010092-uftc8inx 2040 19 2.90 2.90 CD cord-010092-uftc8inx 2040 20 g g NNP cord-010092-uftc8inx 2040 21 / / SYM cord-010092-uftc8inx 2040 22 dl dl NN cord-010092-uftc8inx 2040 23 . . . cord-010092-uftc8inx 2041 1 Net Net NNP cord-010092-uftc8inx 2041 2 Hb Hb NNP cord-010092-uftc8inx 2041 3 content content NN cord-010092-uftc8inx 2041 4 of of IN cord-010092-uftc8inx 2041 5 PRBC PRBC NNP cord-010092-uftc8inx 2041 6 bag bag NN cord-010092-uftc8inx 2041 7 was be VBD cord-010092-uftc8inx 2041 8 lower low JJR cord-010092-uftc8inx 2041 9 in in IN cord-010092-uftc8inx 2041 10 PRBC PRBC NNP cord-010092-uftc8inx 2041 11 prepared prepare VBD cord-010092-uftc8inx 2041 12 from from IN cord-010092-uftc8inx 2041 13 RD RD NNP cord-010092-uftc8inx 2041 14 as as IN cord-010092-uftc8inx 2041 15 compared compare VBN cord-010092-uftc8inx 2041 16 to to IN cord-010092-uftc8inx 2041 17 FTVD FTVD NNP cord-010092-uftc8inx 2041 18 ( ( -LRB- cord-010092-uftc8inx 2041 19 P p NN cord-010092-uftc8inx 2041 20 = = SYM cord-010092-uftc8inx 2041 21 0.0001 0.0001 CD cord-010092-uftc8inx 2041 22 ) ) -RRB- cord-010092-uftc8inx 2041 23 and and CC cord-010092-uftc8inx 2041 24 RTVD RTVD NNP cord-010092-uftc8inx 2041 25 ( ( -LRB- cord-010092-uftc8inx 2041 26 P p NN cord-010092-uftc8inx 2041 27 = = SYM cord-010092-uftc8inx 2041 28 0.008 0.008 CD cord-010092-uftc8inx 2041 29 ) ) -RRB- cord-010092-uftc8inx 2041 30 . . . cord-010092-uftc8inx 2042 1 The the DT cord-010092-uftc8inx 2042 2 Hb Hb NNP cord-010092-uftc8inx 2042 3 content content NN cord-010092-uftc8inx 2042 4 of of IN cord-010092-uftc8inx 2042 5 PRBC PRBC NNP cord-010092-uftc8inx 2042 6 units unit NNS cord-010092-uftc8inx 2042 7 prepared prepare VBN cord-010092-uftc8inx 2042 8 from from IN cord-010092-uftc8inx 2042 9 450 450 CD cord-010092-uftc8inx 2042 10 ml ml NN cord-010092-uftc8inx 2042 11 collection collection NN cord-010092-uftc8inx 2042 12 ranged range VBN cord-010092-uftc8inx 2042 13 from from IN cord-010092-uftc8inx 2042 14 35.19 35.19 CD cord-010092-uftc8inx 2042 15 - - SYM cord-010092-uftc8inx 2042 16 87.36 87.36 CD cord-010092-uftc8inx 2042 17 g g NN cord-010092-uftc8inx 2042 18 and and CC cord-010092-uftc8inx 2042 19 from from IN cord-010092-uftc8inx 2042 20 350 350 CD cord-010092-uftc8inx 2042 21 ml ml NN cord-010092-uftc8inx 2042 22 collection collection NN cord-010092-uftc8inx 2042 23 ranged range VBN cord-010092-uftc8inx 2042 24 from from IN cord-010092-uftc8inx 2042 25 30.77 30.77 CD cord-010092-uftc8inx 2042 26 - - HYPH cord-010092-uftc8inx 2042 27 65.78 65.78 CD cord-010092-uftc8inx 2042 28 g. g. NN cord-010092-uftc8inx 2043 1 We -PRON- PRP cord-010092-uftc8inx 2043 2 observed observe VBD cord-010092-uftc8inx 2043 3 a a DT cord-010092-uftc8inx 2043 4 wide wide JJ cord-010092-uftc8inx 2043 5 range range NN cord-010092-uftc8inx 2043 6 of of IN cord-010092-uftc8inx 2043 7 net net JJ cord-010092-uftc8inx 2043 8 Hb Hb NNP cord-010092-uftc8inx 2043 9 content content NN cord-010092-uftc8inx 2043 10 in in IN cord-010092-uftc8inx 2043 11 the the DT cord-010092-uftc8inx 2043 12 PRBC PRBC NNP cord-010092-uftc8inx 2043 13 units unit NNS cord-010092-uftc8inx 2043 14 and and CC cord-010092-uftc8inx 2043 15 the the DT cord-010092-uftc8inx 2043 16 correlation correlation NN cord-010092-uftc8inx 2043 17 coefficient coefficient NN cord-010092-uftc8inx 2043 18 showed show VBD cord-010092-uftc8inx 2043 19 the the DT cord-010092-uftc8inx 2043 20 strongest strong JJS cord-010092-uftc8inx 2043 21 association association NN cord-010092-uftc8inx 2043 22 of of IN cord-010092-uftc8inx 2043 23 net net JJ cord-010092-uftc8inx 2043 24 Hb Hb NNP cord-010092-uftc8inx 2043 25 content content NN cord-010092-uftc8inx 2043 26 of of IN cord-010092-uftc8inx 2043 27 the the DT cord-010092-uftc8inx 2043 28 PRBC PRBC NNP cord-010092-uftc8inx 2043 29 unit unit NN cord-010092-uftc8inx 2043 30 with with IN cord-010092-uftc8inx 2043 31 the the DT cord-010092-uftc8inx 2043 32 overall overall JJ cord-010092-uftc8inx 2043 33 volume volume NN cord-010092-uftc8inx 2043 34 of of IN cord-010092-uftc8inx 2043 35 PRBC PRBC NNP cord-010092-uftc8inx 2044 1 ( ( -LRB- cord-010092-uftc8inx 2044 2 r r NN cord-010092-uftc8inx 2044 3 = = SYM cord-010092-uftc8inx 2044 4 0.730 0.730 CD cord-010092-uftc8inx 2044 5 , , , cord-010092-uftc8inx 2044 6 P p NN cord-010092-uftc8inx 2044 7 = = SYM cord-010092-uftc8inx 2044 8 0.0001).Higher 0.0001).higher CD cord-010092-uftc8inx 2044 9 volume volume NN cord-010092-uftc8inx 2044 10 PRBCs prbc NNS cord-010092-uftc8inx 2044 11 have have VBP cord-010092-uftc8inx 2044 12 more more JJR cord-010092-uftc8inx 2044 13 Hb Hb NNP cord-010092-uftc8inx 2044 14 content content NN cord-010092-uftc8inx 2044 15 . . . cord-010092-uftc8inx 2045 1 Volume volume NN cord-010092-uftc8inx 2045 2 of of IN cord-010092-uftc8inx 2045 3 PRBC PRBC NNP cord-010092-uftc8inx 2045 4 bags bag NNS cord-010092-uftc8inx 2045 5 in in IN cord-010092-uftc8inx 2045 6 the the DT cord-010092-uftc8inx 2045 7 study study NN cord-010092-uftc8inx 2045 8 ranged range VBD cord-010092-uftc8inx 2045 9 from from IN cord-010092-uftc8inx 2045 10 155 155 CD cord-010092-uftc8inx 2045 11 ml ml NNS cord-010092-uftc8inx 2045 12 to to IN cord-010092-uftc8inx 2045 13 370 370 CD cord-010092-uftc8inx 2045 14 ml ml NN cord-010092-uftc8inx 2045 15 ( ( -LRB- cord-010092-uftc8inx 2045 16 including include VBG cord-010092-uftc8inx 2045 17 both both DT cord-010092-uftc8inx 2045 18 350 350 CD cord-010092-uftc8inx 2045 19 and and CC cord-010092-uftc8inx 2045 20 450 450 CD cord-010092-uftc8inx 2045 21 ml ml NN cord-010092-uftc8inx 2045 22 collections collection NNS cord-010092-uftc8inx 2045 23 ) ) -RRB- cord-010092-uftc8inx 2045 24 . . . cord-010092-uftc8inx 2046 1 Summary Summary NNP cord-010092-uftc8inx 2046 2 / / SYM cord-010092-uftc8inx 2046 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 2046 4 : : : cord-010092-uftc8inx 2047 1 The the DT cord-010092-uftc8inx 2047 2 present present JJ cord-010092-uftc8inx 2047 3 study study NN cord-010092-uftc8inx 2047 4 shows show VBZ cord-010092-uftc8inx 2047 5 that that IN cord-010092-uftc8inx 2047 6 labelling label VBG cord-010092-uftc8inx 2047 7 Hb Hb NNP cord-010092-uftc8inx 2047 8 content content NN cord-010092-uftc8inx 2047 9 of of IN cord-010092-uftc8inx 2047 10 the the DT cord-010092-uftc8inx 2047 11 PRBC PRBC NNP cord-010092-uftc8inx 2047 12 unit unit NN cord-010092-uftc8inx 2047 13 help help NN cord-010092-uftc8inx 2047 14 in in IN cord-010092-uftc8inx 2047 15 better well JJR cord-010092-uftc8inx 2047 16 inventory inventory NN cord-010092-uftc8inx 2047 17 management management NN cord-010092-uftc8inx 2047 18 for for IN cord-010092-uftc8inx 2047 19 patients patient NNS cord-010092-uftc8inx 2047 20 . . . cord-010092-uftc8inx 2048 1 The the DT cord-010092-uftc8inx 2048 2 Hb Hb NNP cord-010092-uftc8inx 2048 3 content content NN cord-010092-uftc8inx 2048 4 may may MD cord-010092-uftc8inx 2048 5 help help VB cord-010092-uftc8inx 2048 6 in in IN cord-010092-uftc8inx 2048 7 decision decision NN cord-010092-uftc8inx 2048 8 making making NN cord-010092-uftc8inx 2048 9 for for IN cord-010092-uftc8inx 2048 10 release release NN cord-010092-uftc8inx 2048 11 of of IN cord-010092-uftc8inx 2048 12 units unit NNS cord-010092-uftc8inx 2048 13 for for IN cord-010092-uftc8inx 2048 14 paediatric paediatric JJ cord-010092-uftc8inx 2048 15 / / SYM cord-010092-uftc8inx 2048 16 low low JJ cord-010092-uftc8inx 2048 17 weight weight NN cord-010092-uftc8inx 2048 18 versus versus IN cord-010092-uftc8inx 2048 19 adults/ adults/ DT cord-010092-uftc8inx 2048 20 higher high JJR cord-010092-uftc8inx 2048 21 weight weight NN cord-010092-uftc8inx 2048 22 patients patient NNS cord-010092-uftc8inx 2048 23 . . . cord-010092-uftc8inx 2049 1 Adopting adopt VBG cord-010092-uftc8inx 2049 2 a a DT cord-010092-uftc8inx 2049 3 policy policy NN cord-010092-uftc8inx 2049 4 of of IN cord-010092-uftc8inx 2049 5 optimizing optimize VBG cord-010092-uftc8inx 2049 6 dosage dosage NN cord-010092-uftc8inx 2049 7 of of IN cord-010092-uftc8inx 2049 8 RBC RBC NNP cord-010092-uftc8inx 2049 9 transfusion transfusion NN cord-010092-uftc8inx 2049 10 could could MD cord-010092-uftc8inx 2049 11 have have VB cord-010092-uftc8inx 2049 12 the the DT cord-010092-uftc8inx 2049 13 potential potential NN cord-010092-uftc8inx 2049 14 to to TO cord-010092-uftc8inx 2049 15 significantly significantly RB cord-010092-uftc8inx 2049 16 improve improve VB cord-010092-uftc8inx 2049 17 RBC RBC NNP cord-010092-uftc8inx 2049 18 utilization utilization NN cord-010092-uftc8inx 2049 19 and and CC cord-010092-uftc8inx 2049 20 decrease decrease VB cord-010092-uftc8inx 2049 21 patient patient JJ cord-010092-uftc8inx 2049 22 exposure exposure NN cord-010092-uftc8inx 2049 23 to to IN cord-010092-uftc8inx 2049 24 allogenic allogenic JJ cord-010092-uftc8inx 2049 25 blood blood NN cord-010092-uftc8inx 2049 26 . . . cord-010092-uftc8inx 2050 1 This this DT cord-010092-uftc8inx 2050 2 would would MD cord-010092-uftc8inx 2050 3 help help VB cord-010092-uftc8inx 2050 4 further far RBR cord-010092-uftc8inx 2050 5 in in IN cord-010092-uftc8inx 2050 6 the the DT cord-010092-uftc8inx 2050 7 clinical clinical JJ cord-010092-uftc8inx 2050 8 transfusion transfusion NN cord-010092-uftc8inx 2050 9 practices practice NNS cord-010092-uftc8inx 2050 10 based base VBN cord-010092-uftc8inx 2050 11 on on IN cord-010092-uftc8inx 2050 12 evidence evidence NN cord-010092-uftc8inx 2050 13 . . . cord-010092-uftc8inx 2051 1 4A 4a LS cord-010092-uftc8inx 2051 2 - - : cord-010092-uftc8inx 2051 3 S17 S17 NNP cord-010092-uftc8inx 2051 4 - - HYPH cord-010092-uftc8inx 2051 5 05 05 CD cord-010092-uftc8inx 2051 6 NV NV NNP cord-010092-uftc8inx 2051 7 More More NNP cord-010092-uftc8inx 2051 8 , , , cord-010092-uftc8inx 2051 9 P P NNP cord-010092-uftc8inx 2051 10 Desai Desai NNP cord-010092-uftc8inx 2051 11 , , , cord-010092-uftc8inx 2051 12 S S NNP cord-010092-uftc8inx 2051 13 Rajadhyaksha Rajadhyaksha NNP cord-010092-uftc8inx 2051 14 , , , cord-010092-uftc8inx 2052 1 A a DT cord-010092-uftc8inx 2052 2 Navkudkar Navkudkar NNP cord-010092-uftc8inx 2052 3 and and CC cord-010092-uftc8inx 2052 4 N N NNP cord-010092-uftc8inx 2052 5 Deshpande Deshpande NNP cord-010092-uftc8inx 2052 6 Transfusion Transfusion NNP cord-010092-uftc8inx 2052 7 Medicine Medicine NNP cord-010092-uftc8inx 2052 8 , , , cord-010092-uftc8inx 2052 9 Tata Tata NNP cord-010092-uftc8inx 2052 10 Memorial Memorial NNP cord-010092-uftc8inx 2052 11 Centre Centre NNP cord-010092-uftc8inx 2052 12 , , , cord-010092-uftc8inx 2052 13 Homi Homi NNP cord-010092-uftc8inx 2052 14 Bhabha Bhabha NNP cord-010092-uftc8inx 2052 15 National National NNP cord-010092-uftc8inx 2052 16 Institute Institute NNP cord-010092-uftc8inx 2052 17 , , , cord-010092-uftc8inx 2052 18 Mumbai Mumbai NNP cord-010092-uftc8inx 2052 19 , , , cord-010092-uftc8inx 2052 20 India India NNP cord-010092-uftc8inx 2052 21 Background Background NNP cord-010092-uftc8inx 2052 22 : : : cord-010092-uftc8inx 2053 1 Red Red NNP cord-010092-uftc8inx 2053 2 Blood Blood NNP cord-010092-uftc8inx 2053 3 Cell Cell NNP cord-010092-uftc8inx 2053 4 ( ( -LRB- cord-010092-uftc8inx 2053 5 RBC RBC NNP cord-010092-uftc8inx 2053 6 ) ) -RRB- cord-010092-uftc8inx 2053 7 transfusion transfusion NN cord-010092-uftc8inx 2053 8 is be VBZ cord-010092-uftc8inx 2053 9 an an DT cord-010092-uftc8inx 2053 10 important important JJ cord-010092-uftc8inx 2053 11 medical medical JJ cord-010092-uftc8inx 2053 12 therapy therapy NN cord-010092-uftc8inx 2053 13 benefiting benefit VBG cord-010092-uftc8inx 2053 14 the the DT cord-010092-uftc8inx 2053 15 patient patient NN cord-010092-uftc8inx 2053 16 in in IN cord-010092-uftc8inx 2053 17 a a DT cord-010092-uftc8inx 2053 18 wide wide JJ cord-010092-uftc8inx 2053 19 spectrum spectrum NN cord-010092-uftc8inx 2053 20 of of IN cord-010092-uftc8inx 2053 21 clinical clinical JJ cord-010092-uftc8inx 2053 22 setting setting NN cord-010092-uftc8inx 2053 23 . . . cord-010092-uftc8inx 2054 1 Critically critically RB cord-010092-uftc8inx 2054 2 ill ill NNP cord-010092-uftc8inx 2054 3 Intensive Intensive NNP cord-010092-uftc8inx 2054 4 Care Care NNP cord-010092-uftc8inx 2054 5 Unit Unit NNP cord-010092-uftc8inx 2054 6 patients patient NNS cord-010092-uftc8inx 2054 7 in in IN cord-010092-uftc8inx 2054 8 particular particular JJ cord-010092-uftc8inx 2054 9 , , , cord-010092-uftc8inx 2054 10 as as RB cord-010092-uftc8inx 2054 11 well well RB cord-010092-uftc8inx 2054 12 as as IN cord-010092-uftc8inx 2054 13 medical medical JJ cord-010092-uftc8inx 2054 14 and and CC cord-010092-uftc8inx 2054 15 hemato hemato JJ cord-010092-uftc8inx 2054 16 - - HYPH cord-010092-uftc8inx 2054 17 oncology oncology NN cord-010092-uftc8inx 2054 18 patients patient NNS cord-010092-uftc8inx 2054 19 , , , cord-010092-uftc8inx 2054 20 are be VBP cord-010092-uftc8inx 2054 21 among among IN cord-010092-uftc8inx 2054 22 the the DT cord-010092-uftc8inx 2054 23 largest large JJS cord-010092-uftc8inx 2054 24 group group NN cord-010092-uftc8inx 2054 25 of of IN cord-010092-uftc8inx 2054 26 the the DT cord-010092-uftc8inx 2054 27 user user NN cord-010092-uftc8inx 2054 28 of of IN cord-010092-uftc8inx 2054 29 RBC RBC NNP cord-010092-uftc8inx 2054 30 . . . cord-010092-uftc8inx 2055 1 Periodic periodic JJ cord-010092-uftc8inx 2055 2 review review NN cord-010092-uftc8inx 2055 3 of of IN cord-010092-uftc8inx 2055 4 blood blood NN cord-010092-uftc8inx 2055 5 components component NNS cord-010092-uftc8inx 2055 6 usage usage NN cord-010092-uftc8inx 2055 7 is be VBZ cord-010092-uftc8inx 2055 8 essential essential JJ cord-010092-uftc8inx 2055 9 to to TO cord-010092-uftc8inx 2055 10 assess assess VB cord-010092-uftc8inx 2055 11 the the DT cord-010092-uftc8inx 2055 12 blood blood NN cord-010092-uftc8inx 2055 13 utilization utilization NN cord-010092-uftc8inx 2055 14 pattern pattern NN cord-010092-uftc8inx 2055 15 in in IN cord-010092-uftc8inx 2055 16 any any DT cord-010092-uftc8inx 2055 17 hospital hospital NN cord-010092-uftc8inx 2055 18 or or CC cord-010092-uftc8inx 2055 19 health health NN cord-010092-uftc8inx 2055 20 care care NN cord-010092-uftc8inx 2055 21 set set VBN cord-010092-uftc8inx 2055 22 up up RP cord-010092-uftc8inx 2055 23 . . . cord-010092-uftc8inx 2056 1 Our -PRON- PRP$ cord-010092-uftc8inx 2056 2 institute institute NN cord-010092-uftc8inx 2056 3 is be VBZ cord-010092-uftc8inx 2056 4 a a DT cord-010092-uftc8inx 2056 5 639 639 CD cord-010092-uftc8inx 2056 6 bedded bed VBN cord-010092-uftc8inx 2056 7 tertiary tertiary JJ cord-010092-uftc8inx 2056 8 care care NN cord-010092-uftc8inx 2056 9 oncology oncology NNP cord-010092-uftc8inx 2056 10 centre centre NN cord-010092-uftc8inx 2056 11 with with IN cord-010092-uftc8inx 2056 12 approximately approximately RB cord-010092-uftc8inx 2056 13 18,000 18,000 CD cord-010092-uftc8inx 2056 14 to to TO cord-010092-uftc8inx 2056 15 20,000 20,000 CD cord-010092-uftc8inx 2056 16 RBC RBC NNP cord-010092-uftc8inx 2056 17 transfusions transfusion NNS cord-010092-uftc8inx 2056 18 annually annually RB cord-010092-uftc8inx 2056 19 . . . cord-010092-uftc8inx 2057 1 These these DT cord-010092-uftc8inx 2057 2 transfusions transfusion NNS cord-010092-uftc8inx 2057 3 are be VBP cord-010092-uftc8inx 2057 4 required require VBN cord-010092-uftc8inx 2057 5 in in IN cord-010092-uftc8inx 2057 6 various various JJ cord-010092-uftc8inx 2057 7 stages stage NNS cord-010092-uftc8inx 2057 8 of of IN cord-010092-uftc8inx 2057 9 patient patient JJ cord-010092-uftc8inx 2057 10 treatment treatment NN cord-010092-uftc8inx 2057 11 like like IN cord-010092-uftc8inx 2057 12 chemotherapy chemotherapy NN cord-010092-uftc8inx 2057 13 , , , cord-010092-uftc8inx 2057 14 radiotherapy radiotherapy NN cord-010092-uftc8inx 2057 15 , , , cord-010092-uftc8inx 2057 16 surgical surgical JJ cord-010092-uftc8inx 2057 17 and and CC cord-010092-uftc8inx 2057 18 palliative palliative JJ cord-010092-uftc8inx 2057 19 care care NN cord-010092-uftc8inx 2058 1 and and CC cord-010092-uftc8inx 2058 2 there there EX cord-010092-uftc8inx 2058 3 are be VBP cord-010092-uftc8inx 2058 4 established establish VBN cord-010092-uftc8inx 2058 5 guidelines guideline NNS cord-010092-uftc8inx 2058 6 by by IN cord-010092-uftc8inx 2058 7 the the DT cord-010092-uftc8inx 2058 8 institute institute NN cord-010092-uftc8inx 2058 9 to to TO cord-010092-uftc8inx 2058 10 be be VB cord-010092-uftc8inx 2058 11 followed follow VBN cord-010092-uftc8inx 2058 12 by by IN cord-010092-uftc8inx 2058 13 clinicians clinician NNS cord-010092-uftc8inx 2058 14 . . . cord-010092-uftc8inx 2059 1 Aims aim VBZ cord-010092-uftc8inx 2059 2 : : : cord-010092-uftc8inx 2060 1 To to TO cord-010092-uftc8inx 2060 2 study study VB cord-010092-uftc8inx 2060 3 clinical clinical JJ cord-010092-uftc8inx 2060 4 practices practice NNS cord-010092-uftc8inx 2060 5 of of IN cord-010092-uftc8inx 2060 6 RBC RBC NNP cord-010092-uftc8inx 2060 7 transfusions transfusion NNS cord-010092-uftc8inx 2060 8 based base VBN cord-010092-uftc8inx 2060 9 on on IN cord-010092-uftc8inx 2060 10 indications indication NNS cord-010092-uftc8inx 2060 11 and and CC cord-010092-uftc8inx 2060 12 to to TO cord-010092-uftc8inx 2060 13 evaluate evaluate VB cord-010092-uftc8inx 2060 14 appropriateness appropriateness NN cord-010092-uftc8inx 2060 15 of of IN cord-010092-uftc8inx 2060 16 RBC RBC NNP cord-010092-uftc8inx 2060 17 utilization utilization NN cord-010092-uftc8inx 2060 18 practices practice NNS cord-010092-uftc8inx 2060 19 at at IN cord-010092-uftc8inx 2060 20 the the DT cord-010092-uftc8inx 2060 21 institute institute NN cord-010092-uftc8inx 2060 22 . . . cord-010092-uftc8inx 2061 1 Methods method NNS cord-010092-uftc8inx 2061 2 : : : cord-010092-uftc8inx 2061 3 This this DT cord-010092-uftc8inx 2061 4 was be VBD cord-010092-uftc8inx 2061 5 a a DT cord-010092-uftc8inx 2061 6 prospective prospective JJ cord-010092-uftc8inx 2061 7 observational observational JJ cord-010092-uftc8inx 2061 8 study study NN cord-010092-uftc8inx 2061 9 , , , cord-010092-uftc8inx 2061 10 started start VBD cord-010092-uftc8inx 2061 11 after after IN cord-010092-uftc8inx 2061 12 approval approval NN cord-010092-uftc8inx 2061 13 from from IN cord-010092-uftc8inx 2061 14 Institutional Institutional NNP cord-010092-uftc8inx 2061 15 Ethics Ethics NNP cord-010092-uftc8inx 2061 16 Committee Committee NNP cord-010092-uftc8inx 2061 17 . . . cord-010092-uftc8inx 2062 1 Total total NN cord-010092-uftc8inx 2062 2 of of IN cord-010092-uftc8inx 2062 3 4413 4413 CD cord-010092-uftc8inx 2062 4 RBC RBC NNP cord-010092-uftc8inx 2062 5 transfusion transfusion NN cord-010092-uftc8inx 2062 6 events event NNS cord-010092-uftc8inx 2062 7 in in IN cord-010092-uftc8inx 2062 8 adult adult NN cord-010092-uftc8inx 2062 9 patients patient NNS cord-010092-uftc8inx 2062 10 over over IN cord-010092-uftc8inx 2062 11 a a DT cord-010092-uftc8inx 2062 12 period period NN cord-010092-uftc8inx 2062 13 of of IN cord-010092-uftc8inx 2062 14 four four CD cord-010092-uftc8inx 2062 15 months month NNS cord-010092-uftc8inx 2062 16 were be VBD cord-010092-uftc8inx 2062 17 included include VBN cord-010092-uftc8inx 2062 18 and and CC cord-010092-uftc8inx 2062 19 analyzed analyze VBN cord-010092-uftc8inx 2062 20 as as IN cord-010092-uftc8inx 2062 21 per per IN cord-010092-uftc8inx 2062 22 institutional institutional JJ cord-010092-uftc8inx 2062 23 guidelines guideline NNS cord-010092-uftc8inx 2062 24 for for IN cord-010092-uftc8inx 2062 25 their -PRON- PRP$ cord-010092-uftc8inx 2062 26 appropriateness appropriateness NN cord-010092-uftc8inx 2062 27 . . . cord-010092-uftc8inx 2063 1 Details detail NNS cord-010092-uftc8inx 2063 2 of of IN cord-010092-uftc8inx 2063 3 transfusion transfusion NN cord-010092-uftc8inx 2063 4 events event NNS cord-010092-uftc8inx 2063 5 in in IN cord-010092-uftc8inx 2063 6 form form NN cord-010092-uftc8inx 2063 7 of of IN cord-010092-uftc8inx 2063 8 pre pre JJ cord-010092-uftc8inx 2063 9 transfusion transfusion NN cord-010092-uftc8inx 2063 10 hemoglobin hemoglobin NN cord-010092-uftc8inx 2063 11 , , , cord-010092-uftc8inx 2063 12 indication indication NN cord-010092-uftc8inx 2063 13 of of IN cord-010092-uftc8inx 2063 14 transfusion transfusion NN cord-010092-uftc8inx 2063 15 , , , cord-010092-uftc8inx 2063 16 type type NN cord-010092-uftc8inx 2063 17 of of IN cord-010092-uftc8inx 2063 18 request request NN cord-010092-uftc8inx 2063 19 , , , cord-010092-uftc8inx 2063 20 number number NN cord-010092-uftc8inx 2063 21 of of IN cord-010092-uftc8inx 2063 22 unit unit NN cord-010092-uftc8inx 2063 23 requested request VBN cord-010092-uftc8inx 2063 24 and and CC cord-010092-uftc8inx 2063 25 issued issue VBN cord-010092-uftc8inx 2063 26 , , , cord-010092-uftc8inx 2063 27 time time NN cord-010092-uftc8inx 2063 28 of of IN cord-010092-uftc8inx 2063 29 issue issue NN cord-010092-uftc8inx 2063 30 , , , cord-010092-uftc8inx 2063 31 site site NN cord-010092-uftc8inx 2063 32 of of IN cord-010092-uftc8inx 2063 33 transfusion transfusion NN cord-010092-uftc8inx 2063 34 and and CC cord-010092-uftc8inx 2063 35 adverse adverse JJ cord-010092-uftc8inx 2063 36 reactions reaction NNS cord-010092-uftc8inx 2063 37 , , , cord-010092-uftc8inx 2063 38 etc etc FW cord-010092-uftc8inx 2063 39 were be VBD cord-010092-uftc8inx 2063 40 obtained obtain VBN cord-010092-uftc8inx 2063 41 from from IN cord-010092-uftc8inx 2063 42 Department Department NNP cord-010092-uftc8inx 2063 43 of of IN cord-010092-uftc8inx 2063 44 Transfusion Transfusion NNP cord-010092-uftc8inx 2063 45 Medicine Medicine NNP cord-010092-uftc8inx 2063 46 records record NNS cord-010092-uftc8inx 2063 47 . . . cord-010092-uftc8inx 2064 1 Overall overall JJ cord-010092-uftc8inx 2064 2 statistical statistical JJ cord-010092-uftc8inx 2064 3 analysis analysis NN cord-010092-uftc8inx 2064 4 was be VBD cord-010092-uftc8inx 2064 5 descriptive descriptive JJ cord-010092-uftc8inx 2064 6 using use VBG cord-010092-uftc8inx 2064 7 SPSS SPSS NNP cord-010092-uftc8inx 2064 8 software software NN cord-010092-uftc8inx 2064 9 . . . cord-010092-uftc8inx 2065 1 Chi Chi NNP cord-010092-uftc8inx 2065 2 - - HYPH cord-010092-uftc8inx 2065 3 square square JJ cord-010092-uftc8inx 2065 4 test test NN cord-010092-uftc8inx 2065 5 in in IN cord-010092-uftc8inx 2065 6 cross cross NN cord-010092-uftc8inx 2065 7 tables table NNS cord-010092-uftc8inx 2065 8 was be VBD cord-010092-uftc8inx 2065 9 applied apply VBN cord-010092-uftc8inx 2065 10 to to TO cord-010092-uftc8inx 2065 11 see see VB cord-010092-uftc8inx 2065 12 the the DT cord-010092-uftc8inx 2065 13 relationship relationship NN cord-010092-uftc8inx 2065 14 between between IN cord-010092-uftc8inx 2065 15 different different JJ cord-010092-uftc8inx 2065 16 variables variable NNS cord-010092-uftc8inx 2065 17 and and CC cord-010092-uftc8inx 2065 18 considered consider VBN cord-010092-uftc8inx 2065 19 significant significant JJ cord-010092-uftc8inx 2065 20 if if IN cord-010092-uftc8inx 2065 21 p p NN cord-010092-uftc8inx 2065 22 - - HYPH cord-010092-uftc8inx 2065 23 value value NN cord-010092-uftc8inx 2065 24 was be VBD cord-010092-uftc8inx 2065 25 < < XX cord-010092-uftc8inx 2065 26 0.05 0.05 CD cord-010092-uftc8inx 2065 27 . . . cord-010092-uftc8inx 2066 1 Results result NNS cord-010092-uftc8inx 2066 2 : : : cord-010092-uftc8inx 2066 3 Total total JJ cord-010092-uftc8inx 2066 4 4413 4413 CD cord-010092-uftc8inx 2066 5 RBC RBC NNP cord-010092-uftc8inx 2066 6 transfusion transfusion NN cord-010092-uftc8inx 2066 7 events event NNS cord-010092-uftc8inx 2066 8 for for IN cord-010092-uftc8inx 2066 9 2012 2012 CD cord-010092-uftc8inx 2066 10 patients patient NNS cord-010092-uftc8inx 2066 11 were be VBD cord-010092-uftc8inx 2066 12 analyzed analyze VBN cord-010092-uftc8inx 2066 13 . . . cord-010092-uftc8inx 2067 1 There there EX cord-010092-uftc8inx 2067 2 were be VBD cord-010092-uftc8inx 2067 3 1877 1877 CD cord-010092-uftc8inx 2067 4 ( ( -LRB- cord-010092-uftc8inx 2067 5 43 43 CD cord-010092-uftc8inx 2067 6 % % NN cord-010092-uftc8inx 2067 7 ) ) -RRB- cord-010092-uftc8inx 2067 8 events event NNS cord-010092-uftc8inx 2067 9 in in IN cord-010092-uftc8inx 2067 10 628 628 CD cord-010092-uftc8inx 2067 11 patients patient NNS cord-010092-uftc8inx 2067 12 of of IN cord-010092-uftc8inx 2067 13 medical medical JJ cord-010092-uftc8inx 2067 14 oncology oncology NN cord-010092-uftc8inx 2067 15 and and CC cord-010092-uftc8inx 2067 16 2536 2536 CD cord-010092-uftc8inx 2067 17 ( ( -LRB- cord-010092-uftc8inx 2067 18 57 57 CD cord-010092-uftc8inx 2067 19 % % NN cord-010092-uftc8inx 2067 20 ) ) -RRB- cord-010092-uftc8inx 2067 21 in in IN cord-010092-uftc8inx 2067 22 1384 1384 CD cord-010092-uftc8inx 2067 23 patients patient NNS cord-010092-uftc8inx 2067 24 of of IN cord-010092-uftc8inx 2067 25 surgical surgical JJ cord-010092-uftc8inx 2067 26 oncology oncology NN cord-010092-uftc8inx 2067 27 . . . cord-010092-uftc8inx 2068 1 Maximum maximum JJ cord-010092-uftc8inx 2068 2 transfusions transfusion NNS cord-010092-uftc8inx 2068 3 were be VBD cord-010092-uftc8inx 2068 4 received receive VBN cord-010092-uftc8inx 2068 5 by by IN cord-010092-uftc8inx 2068 6 patients patient NNS cord-010092-uftc8inx 2068 7 in in IN cord-010092-uftc8inx 2068 8 age age NN cord-010092-uftc8inx 2068 9 group group NN cord-010092-uftc8inx 2068 10 of of IN cord-010092-uftc8inx 2068 11 41 41 CD cord-010092-uftc8inx 2068 12 to to TO cord-010092-uftc8inx 2068 13 60 60 CD cord-010092-uftc8inx 2068 14 years year NNS cord-010092-uftc8inx 2068 15 ( ( -LRB- cord-010092-uftc8inx 2068 16 47 47 CD cord-010092-uftc8inx 2068 17 % % NN cord-010092-uftc8inx 2068 18 ) ) -RRB- cord-010092-uftc8inx 2068 19 . . . cord-010092-uftc8inx 2069 1 Total total JJ cord-010092-uftc8inx 2069 2 83 83 CD cord-010092-uftc8inx 2069 3 % % NN cord-010092-uftc8inx 2069 4 of of IN cord-010092-uftc8inx 2069 5 transfusion transfusion NN cord-010092-uftc8inx 2069 6 events event NNS cord-010092-uftc8inx 2069 7 were be VBD cord-010092-uftc8inx 2069 8 appropriate appropriate JJ cord-010092-uftc8inx 2069 9 as as IN cord-010092-uftc8inx 2069 10 per per IN cord-010092-uftc8inx 2069 11 institutional institutional JJ cord-010092-uftc8inx 2069 12 guidelines guideline NNS cord-010092-uftc8inx 2069 13 . . . cord-010092-uftc8inx 2070 1 All all DT cord-010092-uftc8inx 2070 2 transfusions transfusion NNS cord-010092-uftc8inx 2070 3 administered administer VBN cord-010092-uftc8inx 2070 4 in in IN cord-010092-uftc8inx 2070 5 operation operation NN cord-010092-uftc8inx 2070 6 theatre theatre NN cord-010092-uftc8inx 2070 7 were be VBD cord-010092-uftc8inx 2070 8 found find VBN cord-010092-uftc8inx 2070 9 to to TO cord-010092-uftc8inx 2070 10 be be VB cord-010092-uftc8inx 2070 11 appropriate appropriate JJ cord-010092-uftc8inx 2070 12 with with IN cord-010092-uftc8inx 2070 13 p p NN cord-010092-uftc8inx 2070 14 value value NN cord-010092-uftc8inx 2070 15 < < XX cord-010092-uftc8inx 2070 16 0.05 0.05 CD cord-010092-uftc8inx 2070 17 . . . cord-010092-uftc8inx 2071 1 Inappropriateness Inappropriateness NNP cord-010092-uftc8inx 2071 2 was be VBD cord-010092-uftc8inx 2071 3 more more RBR cord-010092-uftc8inx 2071 4 53%(396/735 53%(396/735 CD cord-010092-uftc8inx 2071 5 ) ) -RRB- cord-010092-uftc8inx 2071 6 and and CC cord-010092-uftc8inx 2071 7 significant significant JJ cord-010092-uftc8inx 2071 8 in in IN cord-010092-uftc8inx 2071 9 daycare daycare NN cord-010092-uftc8inx 2071 10 setup setup NN cord-010092-uftc8inx 2071 11 ( ( -LRB- cord-010092-uftc8inx 2071 12 P p NN cord-010092-uftc8inx 2071 13 < < XX cord-010092-uftc8inx 2071 14 0.05 0.05 CD cord-010092-uftc8inx 2071 15 ) ) -RRB- cord-010092-uftc8inx 2071 16 . . . cord-010092-uftc8inx 2072 1 Anemia anemia NN cord-010092-uftc8inx 2072 2 was be VBD cord-010092-uftc8inx 2072 3 the the DT cord-010092-uftc8inx 2072 4 most most RBS cord-010092-uftc8inx 2072 5 common common JJ cord-010092-uftc8inx 2072 6 indication indication NN cord-010092-uftc8inx 2072 7 of of IN cord-010092-uftc8inx 2072 8 RBC RBC NNP cord-010092-uftc8inx 2072 9 transfusion transfusion NN cord-010092-uftc8inx 2072 10 observed observe VBD cord-010092-uftc8inx 2072 11 in in IN cord-010092-uftc8inx 2072 12 90 90 CD cord-010092-uftc8inx 2072 13 % % NN cord-010092-uftc8inx 2072 14 of of IN cord-010092-uftc8inx 2072 15 events event NNS cord-010092-uftc8inx 2072 16 ( ( -LRB- cord-010092-uftc8inx 2072 17 3971/4413 3971/4413 CD cord-010092-uftc8inx 2072 18 ) ) -RRB- cord-010092-uftc8inx 2072 19 . . . cord-010092-uftc8inx 2073 1 Total total JJ cord-010092-uftc8inx 2073 2 62 62 CD cord-010092-uftc8inx 2073 3 % % NN cord-010092-uftc8inx 2073 4 RBC RBC NNP cord-010092-uftc8inx 2073 5 transfusions transfusion NNS cord-010092-uftc8inx 2073 6 were be VBD cord-010092-uftc8inx 2073 7 given give VBN cord-010092-uftc8inx 2073 8 as as IN cord-010092-uftc8inx 2073 9 planned plan VBN cord-010092-uftc8inx 2073 10 and and CC cord-010092-uftc8inx 2073 11 38 38 CD cord-010092-uftc8inx 2073 12 % % NN cord-010092-uftc8inx 2073 13 as as IN cord-010092-uftc8inx 2073 14 urgent urgent JJ cord-010092-uftc8inx 2073 15 transfusions transfusion NNS cord-010092-uftc8inx 2073 16 . . . cord-010092-uftc8inx 2074 1 Most most RBS cord-010092-uftc8inx 2074 2 common common JJ cord-010092-uftc8inx 2074 3 adverse adverse JJ cord-010092-uftc8inx 2074 4 transfusion transfusion NN cord-010092-uftc8inx 2074 5 event event NN cord-010092-uftc8inx 2074 6 observed observe VBD cord-010092-uftc8inx 2074 7 was be VBD cord-010092-uftc8inx 2074 8 allergic allergic JJ cord-010092-uftc8inx 2074 9 reaction reaction NN cord-010092-uftc8inx 2074 10 in in IN cord-010092-uftc8inx 2074 11 0.3 0.3 CD cord-010092-uftc8inx 2074 12 % % NN cord-010092-uftc8inx 2074 13 of of IN cord-010092-uftc8inx 2074 14 total total JJ cord-010092-uftc8inx 2074 15 transfusion transfusion NN cord-010092-uftc8inx 2074 16 reactions reaction NNS cord-010092-uftc8inx 2074 17 . . . cord-010092-uftc8inx 2075 1 Summary Summary NNP cord-010092-uftc8inx 2075 2 / / SYM cord-010092-uftc8inx 2075 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 2075 4 : : : cord-010092-uftc8inx 2076 1 Clinical clinical JJ cord-010092-uftc8inx 2076 2 practice practice NN cord-010092-uftc8inx 2076 3 of of IN cord-010092-uftc8inx 2076 4 RBC RBC NNP cord-010092-uftc8inx 2076 5 transfusions transfusion NNS cord-010092-uftc8inx 2076 6 in in IN cord-010092-uftc8inx 2076 7 our -PRON- PRP$ cord-010092-uftc8inx 2076 8 hospital hospital NN cord-010092-uftc8inx 2076 9 was be VBD cord-010092-uftc8inx 2076 10 largely largely RB cord-010092-uftc8inx 2076 11 found find VBN cord-010092-uftc8inx 2076 12 to to TO cord-010092-uftc8inx 2076 13 be be VB cord-010092-uftc8inx 2076 14 appropriate appropriate JJ cord-010092-uftc8inx 2076 15 and and CC cord-010092-uftc8inx 2076 16 rational rational JJ cord-010092-uftc8inx 2076 17 with with IN cord-010092-uftc8inx 2076 18 adherence adherence NN cord-010092-uftc8inx 2076 19 to to IN cord-010092-uftc8inx 2076 20 institutional institutional JJ cord-010092-uftc8inx 2076 21 guidelines guideline NNS cord-010092-uftc8inx 2076 22 . . . cord-010092-uftc8inx 2077 1 Blood blood NN cord-010092-uftc8inx 2077 2 utilization utilization NN cord-010092-uftc8inx 2077 3 audits audits NN cord-010092-uftc8inx 2077 4 should should MD cord-010092-uftc8inx 2077 5 be be VB cord-010092-uftc8inx 2077 6 conducted conduct VBN cord-010092-uftc8inx 2077 7 regularly regularly RB cord-010092-uftc8inx 2077 8 by by IN cord-010092-uftc8inx 2077 9 transfusion transfusion NN cord-010092-uftc8inx 2077 10 services service NNS cord-010092-uftc8inx 2077 11 and and CC cord-010092-uftc8inx 2077 12 results result NNS cord-010092-uftc8inx 2077 13 should should MD cord-010092-uftc8inx 2077 14 be be VB cord-010092-uftc8inx 2077 15 discussed discuss VBN cord-010092-uftc8inx 2077 16 with with IN cord-010092-uftc8inx 2077 17 clinician clinician NN cord-010092-uftc8inx 2077 18 for for IN cord-010092-uftc8inx 2077 19 ensuring ensure VBG cord-010092-uftc8inx 2077 20 judicious judicious JJ cord-010092-uftc8inx 2077 21 use use NN cord-010092-uftc8inx 2077 22 of of IN cord-010092-uftc8inx 2077 23 the the DT cord-010092-uftc8inx 2077 24 scarce scarce JJ cord-010092-uftc8inx 2077 25 resource resource NN cord-010092-uftc8inx 2077 26 . . . cord-010092-uftc8inx 2078 1 The the DT cord-010092-uftc8inx 2078 2 concept concept NN cord-010092-uftc8inx 2078 3 of of IN cord-010092-uftc8inx 2078 4 Transfusion Transfusion NNP cord-010092-uftc8inx 2078 5 Safety Safety NNP cord-010092-uftc8inx 2078 6 Officer Officer NNP cord-010092-uftc8inx 2078 7 ( ( -LRB- cord-010092-uftc8inx 2078 8 TSO TSO NNP cord-010092-uftc8inx 2078 9 ) ) -RRB- cord-010092-uftc8inx 2078 10 can can MD cord-010092-uftc8inx 2078 11 be be VB cord-010092-uftc8inx 2078 12 introduced introduce VBN cord-010092-uftc8inx 2078 13 for for IN cord-010092-uftc8inx 2078 14 better well JJR cord-010092-uftc8inx 2078 15 coordination coordination NN cord-010092-uftc8inx 2078 16 between between IN cord-010092-uftc8inx 2078 17 clinicians clinician NNS cord-010092-uftc8inx 2078 18 and and CC cord-010092-uftc8inx 2078 19 blood blood NN cord-010092-uftc8inx 2078 20 transfusion transfusion NN cord-010092-uftc8inx 2078 21 services service NNS cord-010092-uftc8inx 2078 22 to to TO cord-010092-uftc8inx 2078 23 improve improve VB cord-010092-uftc8inx 2078 24 practices practice NNS cord-010092-uftc8inx 2078 25 . . . cord-010092-uftc8inx 2079 1 4A 4a LS cord-010092-uftc8inx 2079 2 - - : cord-010092-uftc8inx 2079 3 S18 S18 NNP cord-010092-uftc8inx 2079 4 - - HYPH cord-010092-uftc8inx 2079 5 01 01 CD cord-010092-uftc8inx 2079 6 Paul Paul NNP cord-010092-uftc8inx 2079 7 - - HYPH cord-010092-uftc8inx 2079 8 Ehrlich Ehrlich NNP cord-010092-uftc8inx 2079 9 - - HYPH cord-010092-uftc8inx 2079 10 Institut Institut NNP cord-010092-uftc8inx 2079 11 , , , cord-010092-uftc8inx 2079 12 Langen Langen NNP cord-010092-uftc8inx 2079 13 , , , cord-010092-uftc8inx 2079 14 Germany Germany NNP cord-010092-uftc8inx 2080 1 On on IN cord-010092-uftc8inx 2080 2 a a DT cord-010092-uftc8inx 2080 3 global global JJ cord-010092-uftc8inx 2080 4 scale scale NN cord-010092-uftc8inx 2080 5 , , , cord-010092-uftc8inx 2080 6 blood blood NN cord-010092-uftc8inx 2080 7 services service NNS cord-010092-uftc8inx 2080 8 are be VBP cord-010092-uftc8inx 2080 9 quite quite RB cord-010092-uftc8inx 2080 10 diverse diverse JJ cord-010092-uftc8inx 2080 11 in in IN cord-010092-uftc8inx 2080 12 regard regard NN cord-010092-uftc8inx 2080 13 to to IN cord-010092-uftc8inx 2080 14 aspects aspect NNS cord-010092-uftc8inx 2080 15 like like IN cord-010092-uftc8inx 2080 16 organisational organisational JJ cord-010092-uftc8inx 2080 17 structure structure NN cord-010092-uftc8inx 2080 18 , , , cord-010092-uftc8inx 2080 19 regulatory regulatory JJ cord-010092-uftc8inx 2080 20 background background NN cord-010092-uftc8inx 2080 21 , , , cord-010092-uftc8inx 2080 22 donor donor NN cord-010092-uftc8inx 2080 23 populations population NNS cord-010092-uftc8inx 2080 24 , , , cord-010092-uftc8inx 2080 25 donation donation NN cord-010092-uftc8inx 2080 26 rates rate NNS cord-010092-uftc8inx 2080 27 or or CC cord-010092-uftc8inx 2080 28 pathogen pathogen NN cord-010092-uftc8inx 2080 29 epidemiology epidemiology NN cord-010092-uftc8inx 2080 30 . . . cord-010092-uftc8inx 2081 1 The the DT cord-010092-uftc8inx 2081 2 World World NNP cord-010092-uftc8inx 2081 3 Health Health NNP cord-010092-uftc8inx 2081 4 Organization Organization NNP cord-010092-uftc8inx 2081 5 ( ( -LRB- cord-010092-uftc8inx 2081 6 WHO who WP cord-010092-uftc8inx 2081 7 ) ) -RRB- cord-010092-uftc8inx 2081 8 recognizes recognize VBZ cord-010092-uftc8inx 2081 9 blood blood NN cord-010092-uftc8inx 2081 10 and and CC cord-010092-uftc8inx 2081 11 blood blood NN cord-010092-uftc8inx 2081 12 products product NNS cord-010092-uftc8inx 2081 13 as as IN cord-010092-uftc8inx 2081 14 essential essential JJ cord-010092-uftc8inx 2081 15 medicines medicine NNS cord-010092-uftc8inx 2081 16 and and CC cord-010092-uftc8inx 2081 17 provides provide VBZ cord-010092-uftc8inx 2081 18 guidance guidance NN cord-010092-uftc8inx 2081 19 to to IN cord-010092-uftc8inx 2081 20 member member NN cord-010092-uftc8inx 2081 21 states state NNS cord-010092-uftc8inx 2081 22 for for IN cord-010092-uftc8inx 2081 23 various various JJ cord-010092-uftc8inx 2081 24 aspects aspect NNS cord-010092-uftc8inx 2081 25 like like IN cord-010092-uftc8inx 2081 26 blood blood NN cord-010092-uftc8inx 2081 27 regulation regulation NN cord-010092-uftc8inx 2081 28 , , , cord-010092-uftc8inx 2081 29 best good JJS cord-010092-uftc8inx 2081 30 practices practice NNS cord-010092-uftc8inx 2081 31 in in IN cord-010092-uftc8inx 2081 32 blood blood NN cord-010092-uftc8inx 2081 33 collection collection NN cord-010092-uftc8inx 2081 34 and and CC cord-010092-uftc8inx 2081 35 transfusion transfusion NN cord-010092-uftc8inx 2081 36 , , , cord-010092-uftc8inx 2081 37 or or CC cord-010092-uftc8inx 2081 38 screening screening NN cord-010092-uftc8inx 2081 39 parameters parameter NNS cord-010092-uftc8inx 2081 40 . . . cord-010092-uftc8inx 2082 1 More more RBR cord-010092-uftc8inx 2082 2 recently recently RB cord-010092-uftc8inx 2082 3 a a DT cord-010092-uftc8inx 2082 4 WHO WHO NNP cord-010092-uftc8inx 2082 5 guideline guideline NN cord-010092-uftc8inx 2082 6 on on IN cord-010092-uftc8inx 2082 7 residual residual JJ cord-010092-uftc8inx 2082 8 risk risk NN cord-010092-uftc8inx 2082 9 of of IN cord-010092-uftc8inx 2082 10 transfusion transfusion NN cord-010092-uftc8inx 2082 11 associated associate VBN cord-010092-uftc8inx 2082 12 infections infection NNS cord-010092-uftc8inx 2082 13 has have VBZ cord-010092-uftc8inx 2082 14 been be VBN cord-010092-uftc8inx 2082 15 established establish VBN cord-010092-uftc8inx 2082 16 which which WDT cord-010092-uftc8inx 2082 17 may may MD cord-010092-uftc8inx 2082 18 facilitate facilitate VB cord-010092-uftc8inx 2082 19 decision decision NN cord-010092-uftc8inx 2082 20 - - HYPH cord-010092-uftc8inx 2082 21 making making NN cord-010092-uftc8inx 2082 22 for for IN cord-010092-uftc8inx 2082 23 the the DT cord-010092-uftc8inx 2082 24 most most RBS cord-010092-uftc8inx 2082 25 appropriate appropriate JJ cord-010092-uftc8inx 2082 26 screening screening NN cord-010092-uftc8inx 2082 27 algorithms algorithm NNS cord-010092-uftc8inx 2082 28 . . . cord-010092-uftc8inx 2083 1 It -PRON- PRP cord-010092-uftc8inx 2083 2 emphasizes emphasize VBZ cord-010092-uftc8inx 2083 3 the the DT cord-010092-uftc8inx 2083 4 need need NN cord-010092-uftc8inx 2083 5 for for IN cord-010092-uftc8inx 2083 6 regional regional JJ cord-010092-uftc8inx 2083 7 evaluation evaluation NN cord-010092-uftc8inx 2083 8 of of IN cord-010092-uftc8inx 2083 9 screening screen VBG cord-010092-uftc8inx 2083 10 assays assay NNS cord-010092-uftc8inx 2083 11 and and CC cord-010092-uftc8inx 2083 12 regulatory regulatory JJ cord-010092-uftc8inx 2083 13 control control NN cord-010092-uftc8inx 2083 14 of of IN cord-010092-uftc8inx 2083 15 blood blood NN cord-010092-uftc8inx 2083 16 - - HYPH cord-010092-uftc8inx 2083 17 associated associate VBN cord-010092-uftc8inx 2083 18 IVDs ivds NN cord-010092-uftc8inx 2083 19 . . . cord-010092-uftc8inx 2084 1 Background background NN cord-010092-uftc8inx 2084 2 : : : cord-010092-uftc8inx 2085 1 Babesia Babesia NNP cord-010092-uftc8inx 2085 2 , , , cord-010092-uftc8inx 2085 3 a a DT cord-010092-uftc8inx 2085 4 protozoan protozoan NN cord-010092-uftc8inx 2085 5 parasite parasite NN cord-010092-uftc8inx 2085 6 that that WDT cord-010092-uftc8inx 2085 7 infects infect VBZ cord-010092-uftc8inx 2085 8 red red JJ cord-010092-uftc8inx 2085 9 blood blood NN cord-010092-uftc8inx 2085 10 cells cell NNS cord-010092-uftc8inx 2085 11 , , , cord-010092-uftc8inx 2085 12 is be VBZ cord-010092-uftc8inx 2085 13 a a DT cord-010092-uftc8inx 2085 14 leading lead VBG cord-010092-uftc8inx 2085 15 infectious infectious JJ cord-010092-uftc8inx 2085 16 cause cause NN cord-010092-uftc8inx 2085 17 of of IN cord-010092-uftc8inx 2085 18 mortality mortality NN cord-010092-uftc8inx 2085 19 in in IN cord-010092-uftc8inx 2085 20 U.S. U.S. NNP cord-010092-uftc8inx 2085 21 transfusion transfusion NN cord-010092-uftc8inx 2085 22 recipients recipient NNS cord-010092-uftc8inx 2085 23 . . . cord-010092-uftc8inx 2086 1 Babesia Babesia NNP cord-010092-uftc8inx 2086 2 is be VBZ cord-010092-uftc8inx 2086 3 usually usually RB cord-010092-uftc8inx 2086 4 transmitted transmit VBN cord-010092-uftc8inx 2086 5 through through IN cord-010092-uftc8inx 2086 6 the the DT cord-010092-uftc8inx 2086 7 bite bite NN cord-010092-uftc8inx 2086 8 of of IN cord-010092-uftc8inx 2086 9 an an DT cord-010092-uftc8inx 2086 10 infected infected JJ cord-010092-uftc8inx 2086 11 tick tick NN cord-010092-uftc8inx 2086 12 but but CC cord-010092-uftc8inx 2086 13 may may MD cord-010092-uftc8inx 2086 14 be be VB cord-010092-uftc8inx 2086 15 transfusion transfusion NN cord-010092-uftc8inx 2086 16 transmitted transmit VBN cord-010092-uftc8inx 2086 17 ( ( -LRB- cord-010092-uftc8inx 2086 18 TT TT NNP cord-010092-uftc8inx 2086 19 ) ) -RRB- cord-010092-uftc8inx 2086 20 or or CC cord-010092-uftc8inx 2086 21 transmitted transmit VBN cord-010092-uftc8inx 2086 22 from from IN cord-010092-uftc8inx 2086 23 mother mother NN cord-010092-uftc8inx 2086 24 to to IN cord-010092-uftc8inx 2086 25 child child NN cord-010092-uftc8inx 2086 26 during during IN cord-010092-uftc8inx 2086 27 pregnancy pregnancy NN cord-010092-uftc8inx 2086 28 . . . cord-010092-uftc8inx 2087 1 Babesiosis babesiosis NN cord-010092-uftc8inx 2087 2 is be VBZ cord-010092-uftc8inx 2087 3 a a DT cord-010092-uftc8inx 2087 4 world world NN cord-010092-uftc8inx 2087 5 - - HYPH cord-010092-uftc8inx 2087 6 wide wide JJ cord-010092-uftc8inx 2087 7 disease disease NN cord-010092-uftc8inx 2087 8 ; ; : cord-010092-uftc8inx 2087 9 the the DT cord-010092-uftc8inx 2087 10 ticks tick NNS cord-010092-uftc8inx 2087 11 that that WDT cord-010092-uftc8inx 2087 12 carry carry VBP cord-010092-uftc8inx 2087 13 Babesia Babesia NNP cord-010092-uftc8inx 2087 14 have have VB cord-010092-uftc8inx 2087 15 a a DT cord-010092-uftc8inx 2087 16 global global JJ cord-010092-uftc8inx 2087 17 distribution distribution NN cord-010092-uftc8inx 2087 18 . . . cord-010092-uftc8inx 2088 1 Babesiosis babesiosis NN cord-010092-uftc8inx 2088 2 has have VBZ cord-010092-uftc8inx 2088 3 been be VBN cord-010092-uftc8inx 2088 4 reported report VBN cord-010092-uftc8inx 2088 5 throughout throughout IN cord-010092-uftc8inx 2088 6 Europe Europe NNP cord-010092-uftc8inx 2088 7 and and CC cord-010092-uftc8inx 2088 8 in in IN cord-010092-uftc8inx 2088 9 Canada Canada NNP cord-010092-uftc8inx 2088 10 , , , cord-010092-uftc8inx 2088 11 Korea Korea NNP cord-010092-uftc8inx 2088 12 , , , cord-010092-uftc8inx 2088 13 India India NNP cord-010092-uftc8inx 2088 14 , , , cord-010092-uftc8inx 2088 15 and and CC cord-010092-uftc8inx 2088 16 Japan Japan NNP cord-010092-uftc8inx 2088 17 . . . cord-010092-uftc8inx 2089 1 Prospective prospective JJ cord-010092-uftc8inx 2089 2 testing testing NN cord-010092-uftc8inx 2089 3 of of IN cord-010092-uftc8inx 2089 4 blood blood NN cord-010092-uftc8inx 2089 5 donations donation NNS cord-010092-uftc8inx 2089 6 in in IN cord-010092-uftc8inx 2089 7 endemic endemic JJ cord-010092-uftc8inx 2089 8 areas area NNS cord-010092-uftc8inx 2089 9 of of IN cord-010092-uftc8inx 2089 10 the the DT cord-010092-uftc8inx 2089 11 U.S. U.S. NNP cord-010092-uftc8inx 2089 12 revealed reveal VBD cord-010092-uftc8inx 2089 13 0.38 0.38 CD cord-010092-uftc8inx 2089 14 % % NN cord-010092-uftc8inx 2089 15 of of IN cord-010092-uftc8inx 2089 16 donors donor NNS cord-010092-uftc8inx 2089 17 were be VBD cord-010092-uftc8inx 2089 18 positive positive JJ cord-010092-uftc8inx 2089 19 for for IN cord-010092-uftc8inx 2089 20 Babesia Babesia NNP cord-010092-uftc8inx 2089 21 DNA DNA NNP cord-010092-uftc8inx 2089 22 or or CC cord-010092-uftc8inx 2089 23 antibodies antibody NNS cord-010092-uftc8inx 2089 24 ( ( -LRB- cord-010092-uftc8inx 2089 25 Moritz Moritz NNP cord-010092-uftc8inx 2089 26 , , , cord-010092-uftc8inx 2089 27 NEJM NEJM NNP cord-010092-uftc8inx 2089 28 , , , cord-010092-uftc8inx 2089 29 2016 2016 CD cord-010092-uftc8inx 2089 30 ) ) -RRB- cord-010092-uftc8inx 2090 1 Aims aim VBZ cord-010092-uftc8inx 2090 2 : : : cord-010092-uftc8inx 2091 1 -To -To : cord-010092-uftc8inx 2091 2 report report NN cord-010092-uftc8inx 2091 3 results result NNS cord-010092-uftc8inx 2091 4 of of IN cord-010092-uftc8inx 2091 5 ongoing ongoing JJ cord-010092-uftc8inx 2091 6 Babesia Babesia NNP cord-010092-uftc8inx 2091 7 clinical clinical JJ cord-010092-uftc8inx 2091 8 trial trial NN cord-010092-uftc8inx 2091 9 -To -to TO cord-010092-uftc8inx 2091 10 explain explain VB cord-010092-uftc8inx 2091 11 significance significance NN cord-010092-uftc8inx 2091 12 of of IN cord-010092-uftc8inx 2091 13 Babesia Babesia NNP cord-010092-uftc8inx 2091 14 as as IN cord-010092-uftc8inx 2091 15 a a DT cord-010092-uftc8inx 2091 16 TT TT NNP cord-010092-uftc8inx 2091 17 infection infection NN cord-010092-uftc8inx 2091 18 Methods method NNS cord-010092-uftc8inx 2091 19 : : : cord-010092-uftc8inx 2092 1 In in IN cord-010092-uftc8inx 2092 2 cobas cobas NNP cord-010092-uftc8inx 2092 3 â â . cord-010092-uftc8inx 2093 1 Babesia babesia NN cord-010092-uftc8inx 2093 2 for for IN cord-010092-uftc8inx 2093 3 use use NN cord-010092-uftc8inx 2093 4 on on IN cord-010092-uftc8inx 2093 5 the the DT cord-010092-uftc8inx 2093 6 cobas cobas NNP cord-010092-uftc8inx 2093 7 â â CD cord-010092-uftc8inx 2093 8 6800/8800 6800/8800 CD cord-010092-uftc8inx 2093 9 Systems Systems NNPS cord-010092-uftc8inx 2093 10 , , , cord-010092-uftc8inx 2093 11 is be VBZ cord-010092-uftc8inx 2093 12 a a DT cord-010092-uftc8inx 2093 13 qualitative qualitative JJ cord-010092-uftc8inx 2093 14 polymerase polymerase NN cord-010092-uftc8inx 2093 15 chain chain NN cord-010092-uftc8inx 2093 16 reaction reaction NN cord-010092-uftc8inx 2093 17 nucleic nucleic VBD cord-010092-uftc8inx 2093 18 acid acid NN cord-010092-uftc8inx 2093 19 amplification amplification NN cord-010092-uftc8inx 2093 20 test test NN cord-010092-uftc8inx 2093 21 , , , cord-010092-uftc8inx 2093 22 developed develop VBD cord-010092-uftc8inx 2093 23 to to TO cord-010092-uftc8inx 2093 24 detect detect VB cord-010092-uftc8inx 2093 25 in in IN cord-010092-uftc8inx 2093 26 whole whole JJ cord-010092-uftc8inx 2093 27 blood blood NN cord-010092-uftc8inx 2093 28 ( ( -LRB- cord-010092-uftc8inx 2093 29 WB WB NNP cord-010092-uftc8inx 2093 30 ) ) -RRB- cord-010092-uftc8inx 2093 31 donor donor NN cord-010092-uftc8inx 2093 32 samples sample NNS cord-010092-uftc8inx 2093 33 the the DT cord-010092-uftc8inx 2093 34 4 4 CD cord-010092-uftc8inx 2093 35 Babesia Babesia NNP cord-010092-uftc8inx 2093 36 species specie NNS cord-010092-uftc8inx 2093 37 that that WDT cord-010092-uftc8inx 2093 38 cause cause VBP cord-010092-uftc8inx 2093 39 human human JJ cord-010092-uftc8inx 2093 40 disease disease NN cord-010092-uftc8inx 2093 41 : : : cord-010092-uftc8inx 2093 42 B. B. NNP cord-010092-uftc8inx 2093 43 microti microti NNP cord-010092-uftc8inx 2093 44 , , , cord-010092-uftc8inx 2093 45 B. B. NNP cord-010092-uftc8inx 2093 46 duncani duncani NNP cord-010092-uftc8inx 2093 47 , , , cord-010092-uftc8inx 2093 48 B. B. NNP cord-010092-uftc8inx 2093 49 divergens divergens NNP cord-010092-uftc8inx 2093 50 , , , cord-010092-uftc8inx 2093 51 and and CC cord-010092-uftc8inx 2093 52 B. B. NNP cord-010092-uftc8inx 2093 53 venatorum venatorum NNP cord-010092-uftc8inx 2093 54 . . . cord-010092-uftc8inx 2094 1 Testing testing NN cord-010092-uftc8inx 2094 2 began begin VBD cord-010092-uftc8inx 2094 3 in in IN cord-010092-uftc8inx 2094 4 October October NNP cord-010092-uftc8inx 2094 5 2017 2017 CD cord-010092-uftc8inx 2094 6 under under IN cord-010092-uftc8inx 2094 7 a a DT cord-010092-uftc8inx 2094 8 U.S. U.S. NNP cord-010092-uftc8inx 2094 9 FDA FDA NNP cord-010092-uftc8inx 2094 10 - - HYPH cord-010092-uftc8inx 2094 11 approved approve VBN cord-010092-uftc8inx 2094 12 Investigational Investigational NNP cord-010092-uftc8inx 2094 13 New New NNP cord-010092-uftc8inx 2094 14 Drug Drug NNP cord-010092-uftc8inx 2094 15 Application Application NNP cord-010092-uftc8inx 2094 16 . . . cord-010092-uftc8inx 2095 1 WB WB NNP cord-010092-uftc8inx 2095 2 was be VBD cord-010092-uftc8inx 2095 3 collected collect VBN cord-010092-uftc8inx 2095 4 into into IN cord-010092-uftc8inx 2095 5 a a DT cord-010092-uftc8inx 2095 6 proprietary proprietary JJ cord-010092-uftc8inx 2095 7 medium medium NN cord-010092-uftc8inx 2095 8 that that WDT cord-010092-uftc8inx 2095 9 lysed lyse VBD cord-010092-uftc8inx 2095 10 red red JJ cord-010092-uftc8inx 2095 11 blood blood NN cord-010092-uftc8inx 2095 12 cells cell NNS cord-010092-uftc8inx 2095 13 and and CC cord-010092-uftc8inx 2095 14 stabilized stabilize VBD cord-010092-uftc8inx 2095 15 Babesia Babesia NNP cord-010092-uftc8inx 2095 16 RNA RNA NNP cord-010092-uftc8inx 2095 17 and and CC cord-010092-uftc8inx 2095 18 DNA DNA NNP cord-010092-uftc8inx 2095 19 . . . cord-010092-uftc8inx 2096 1 Donations donation NNS cord-010092-uftc8inx 2096 2 were be VBD cord-010092-uftc8inx 2096 3 collected collect VBN cord-010092-uftc8inx 2096 4 in in IN cord-010092-uftc8inx 2096 5 states state NNS cord-010092-uftc8inx 2096 6 with with IN cord-010092-uftc8inx 2096 7 high high JJ cord-010092-uftc8inx 2096 8 , , , cord-010092-uftc8inx 2096 9 low low JJ cord-010092-uftc8inx 2096 10 , , , cord-010092-uftc8inx 2096 11 and and CC cord-010092-uftc8inx 2096 12 no no DT cord-010092-uftc8inx 2096 13 Babesia Babesia NNP cord-010092-uftc8inx 2096 14 endemicity endemicity NN cord-010092-uftc8inx 2096 15 and and CC cord-010092-uftc8inx 2096 16 screened screen VBN cord-010092-uftc8inx 2096 17 as as IN cord-010092-uftc8inx 2096 18 individual individual JJ cord-010092-uftc8inx 2096 19 blood blood NN cord-010092-uftc8inx 2096 20 donor donor NN cord-010092-uftc8inx 2096 21 ( ( -LRB- cord-010092-uftc8inx 2096 22 IDT IDT NNP cord-010092-uftc8inx 2096 23 ) ) -RRB- cord-010092-uftc8inx 2096 24 samples sample NNS cord-010092-uftc8inx 2096 25 . . . cord-010092-uftc8inx 2097 1 Reactive reactive JJ cord-010092-uftc8inx 2097 2 index index NN cord-010092-uftc8inx 2097 3 donations donation NNS cord-010092-uftc8inx 2097 4 were be VBD cord-010092-uftc8inx 2097 5 retested reteste VBN cord-010092-uftc8inx 2097 6 in in IN cord-010092-uftc8inx 2097 7 simulated simulated JJ cord-010092-uftc8inx 2097 8 minipools minipool NNS cord-010092-uftc8inx 2097 9 of of IN cord-010092-uftc8inx 2097 10 6 6 CD cord-010092-uftc8inx 2097 11 ( ( -LRB- cord-010092-uftc8inx 2097 12 MP6 MP6 NNP cord-010092-uftc8inx 2097 13 ) ) -RRB- cord-010092-uftc8inx 2097 14 , , , cord-010092-uftc8inx 2097 15 plus plus CC cord-010092-uftc8inx 2097 16 3 3 CD cord-010092-uftc8inx 2097 17 IDT IDT NNP cord-010092-uftc8inx 2097 18 replicates replicate VBZ cord-010092-uftc8inx 2097 19 with with IN cord-010092-uftc8inx 2097 20 cobas cobas NNP cord-010092-uftc8inx 2098 1 â â LS cord-010092-uftc8inx 2099 1 Babesia Babesia NNP cord-010092-uftc8inx 2099 2 . . . cord-010092-uftc8inx 2100 1 Reactive reactive JJ cord-010092-uftc8inx 2100 2 index index NN cord-010092-uftc8inx 2100 3 donations donation NNS cord-010092-uftc8inx 2100 4 were be VBD cord-010092-uftc8inx 2100 5 also also RB cord-010092-uftc8inx 2100 6 tested test VBN cord-010092-uftc8inx 2100 7 with with IN cord-010092-uftc8inx 2100 8 2 2 CD cord-010092-uftc8inx 2100 9 validated validate VBN cord-010092-uftc8inx 2100 10 alternate alternate JJ cord-010092-uftc8inx 2100 11 Babesia Babesia NNP cord-010092-uftc8inx 2100 12 NAT NAT NNP cord-010092-uftc8inx 2100 13 and and CC cord-010092-uftc8inx 2100 14 for for IN cord-010092-uftc8inx 2100 15 B. B. NNP cord-010092-uftc8inx 2100 16 microti microti NNP cord-010092-uftc8inx 2100 17 IgM IgM NNP cord-010092-uftc8inx 2100 18 and and CC cord-010092-uftc8inx 2100 19 IgG IgG NNP cord-010092-uftc8inx 2100 20 antibodies antibody NNS cord-010092-uftc8inx 2100 21 . . . cord-010092-uftc8inx 2101 1 Donors donor NNS cord-010092-uftc8inx 2101 2 with with IN cord-010092-uftc8inx 2101 3 reactive reactive JJ cord-010092-uftc8inx 2101 4 results result NNS cord-010092-uftc8inx 2101 5 were be VBD cord-010092-uftc8inx 2101 6 invited invite VBN cord-010092-uftc8inx 2101 7 to to TO cord-010092-uftc8inx 2101 8 enroll enroll VB cord-010092-uftc8inx 2101 9 in in IN cord-010092-uftc8inx 2101 10 a a DT cord-010092-uftc8inx 2101 11 follow follow VB cord-010092-uftc8inx 2101 12 - - HYPH cord-010092-uftc8inx 2101 13 up up NN cord-010092-uftc8inx 2101 14 study study NN cord-010092-uftc8inx 2101 15 to to TO cord-010092-uftc8inx 2101 16 test test VB cord-010092-uftc8inx 2101 17 for for IN cord-010092-uftc8inx 2101 18 additional additional JJ cord-010092-uftc8inx 2101 19 evidence evidence NN cord-010092-uftc8inx 2101 20 of of IN cord-010092-uftc8inx 2101 21 infection infection NN cord-010092-uftc8inx 2101 22 . . . cord-010092-uftc8inx 2102 1 Results result NNS cord-010092-uftc8inx 2102 2 : : : cord-010092-uftc8inx 2103 1 To to IN cord-010092-uftc8inx 2103 2 date date NN cord-010092-uftc8inx 2103 3 , , , cord-010092-uftc8inx 2103 4 256,802 256,802 CD cord-010092-uftc8inx 2103 5 valid valid JJ cord-010092-uftc8inx 2103 6 donations donation NNS cord-010092-uftc8inx 2103 7 have have VBP cord-010092-uftc8inx 2103 8 been be VBN cord-010092-uftc8inx 2103 9 screened screen VBN cord-010092-uftc8inx 2103 10 with with IN cord-010092-uftc8inx 2103 11 cobas cobas NNP cord-010092-uftc8inx 2104 1 â â LS cord-010092-uftc8inx 2105 1 Babesia Babesia NNP cord-010092-uftc8inx 2105 2 , , , cord-010092-uftc8inx 2105 3 and and CC cord-010092-uftc8inx 2105 4 15 15 CD cord-010092-uftc8inx 2105 5 ( ( -LRB- cord-010092-uftc8inx 2105 6 0.006 0.006 CD cord-010092-uftc8inx 2105 7 % % NN cord-010092-uftc8inx 2105 8 ) ) -RRB- cord-010092-uftc8inx 2105 9 were be VBD cord-010092-uftc8inx 2105 10 reactive reactive JJ cord-010092-uftc8inx 2105 11 . . . cord-010092-uftc8inx 2106 1 13 13 CD cord-010092-uftc8inx 2106 2 of of IN cord-010092-uftc8inx 2106 3 15 15 CD cord-010092-uftc8inx 2106 4 ( ( -LRB- cord-010092-uftc8inx 2106 5 87 87 CD cord-010092-uftc8inx 2106 6 % % NN cord-010092-uftc8inx 2106 7 ) ) -RRB- cord-010092-uftc8inx 2106 8 initially initially RB cord-010092-uftc8inx 2106 9 - - HYPH cord-010092-uftc8inx 2106 10 reactive reactive JJ cord-010092-uftc8inx 2106 11 donations donation NNS cord-010092-uftc8inx 2106 12 were be VBD cord-010092-uftc8inx 2106 13 confirmed confirm VBN cord-010092-uftc8inx 2106 14 to to TO cord-010092-uftc8inx 2106 15 be be VB cord-010092-uftc8inx 2106 16 positive positive JJ cord-010092-uftc8inx 2106 17 for for IN cord-010092-uftc8inx 2106 18 Babesia Babesia NNP cord-010092-uftc8inx 2106 19 with with IN cord-010092-uftc8inx 2106 20 a a DT cord-010092-uftc8inx 2106 21 positive positive JJ cord-010092-uftc8inx 2106 22 alternate alternate JJ cord-010092-uftc8inx 2106 23 NAT NAT NNP cord-010092-uftc8inx 2106 24 or or CC cord-010092-uftc8inx 2106 25 serology serology NN cord-010092-uftc8inx 2106 26 result result NN cord-010092-uftc8inx 2106 27 . . . cord-010092-uftc8inx 2107 1 1 1 CD cord-010092-uftc8inx 2107 2 of of IN cord-010092-uftc8inx 2107 3 13 13 CD cord-010092-uftc8inx 2107 4 ( ( -LRB- cord-010092-uftc8inx 2107 5 8 8 CD cord-010092-uftc8inx 2107 6 % % NN cord-010092-uftc8inx 2107 7 ) ) -RRB- cord-010092-uftc8inx 2107 8 confirmed confirm VBN cord-010092-uftc8inx 2107 9 - - HYPH cord-010092-uftc8inx 2107 10 positive positive JJ cord-010092-uftc8inx 2107 11 donations donation NNS cord-010092-uftc8inx 2107 12 was be VBD cord-010092-uftc8inx 2107 13 collected collect VBN cord-010092-uftc8inx 2107 14 in in IN cord-010092-uftc8inx 2107 15 a a DT cord-010092-uftc8inx 2107 16 state state NN cord-010092-uftc8inx 2107 17 with with IN cord-010092-uftc8inx 2107 18 low low JJ cord-010092-uftc8inx 2107 19 Babesia Babesia NNP cord-010092-uftc8inx 2107 20 endemicity endemicity NN cord-010092-uftc8inx 2107 21 ( ( -LRB- cord-010092-uftc8inx 2107 22 Pennsylvania Pennsylvania NNP cord-010092-uftc8inx 2107 23 ) ) -RRB- cord-010092-uftc8inx 2107 24 , , , cord-010092-uftc8inx 2107 25 and and CC cord-010092-uftc8inx 2107 26 1 1 CD cord-010092-uftc8inx 2107 27 ( ( -LRB- cord-010092-uftc8inx 2107 28 8 8 CD cord-010092-uftc8inx 2107 29 % % NN cord-010092-uftc8inx 2107 30 ) ) -RRB- cord-010092-uftc8inx 2107 31 was be VBD cord-010092-uftc8inx 2107 32 collected collect VBN cord-010092-uftc8inx 2107 33 in in IN cord-010092-uftc8inx 2107 34 a a DT cord-010092-uftc8inx 2107 35 state state NN cord-010092-uftc8inx 2107 36 where where WRB cord-010092-uftc8inx 2107 37 Babesia Babesia NNP cord-010092-uftc8inx 2107 38 is be VBZ cord-010092-uftc8inx 2107 39 not not RB cord-010092-uftc8inx 2107 40 considered consider VBN cord-010092-uftc8inx 2107 41 endemic endemic JJ cord-010092-uftc8inx 2107 42 ( ( -LRB- cord-010092-uftc8inx 2107 43 Iowa Iowa NNP cord-010092-uftc8inx 2107 44 ) ) -RRB- cord-010092-uftc8inx 2107 45 . . . cord-010092-uftc8inx 2108 1 11 11 CD cord-010092-uftc8inx 2108 2 of of IN cord-010092-uftc8inx 2108 3 13 13 CD cord-010092-uftc8inx 2108 4 ( ( -LRB- cord-010092-uftc8inx 2108 5 85 85 CD cord-010092-uftc8inx 2108 6 % % NN cord-010092-uftc8inx 2108 7 ) ) -RRB- cord-010092-uftc8inx 2108 8 confirmed confirm VBD cord-010092-uftc8inx 2108 9 positive positive JJ cord-010092-uftc8inx 2108 10 donations donation NNS cord-010092-uftc8inx 2108 11 were be VBD cord-010092-uftc8inx 2108 12 collected collect VBN cord-010092-uftc8inx 2108 13 in in IN cord-010092-uftc8inx 2108 14 states state NNS cord-010092-uftc8inx 2108 15 with with IN cord-010092-uftc8inx 2108 16 high high JJ cord-010092-uftc8inx 2108 17 endemicity endemicity NN cord-010092-uftc8inx 2108 18 . . . cord-010092-uftc8inx 2109 1 8 8 CD cord-010092-uftc8inx 2109 2 of of IN cord-010092-uftc8inx 2109 3 13 13 CD cord-010092-uftc8inx 2109 4 ( ( -LRB- cord-010092-uftc8inx 2109 5 62 62 CD cord-010092-uftc8inx 2109 6 % % NN cord-010092-uftc8inx 2109 7 ) ) -RRB- cord-010092-uftc8inx 2109 8 confirmed confirm VBD cord-010092-uftc8inx 2109 9 Babesia Babesia NNP cord-010092-uftc8inx 2109 10 - - HYPH cord-010092-uftc8inx 2109 11 positive positive JJ cord-010092-uftc8inx 2109 12 donations donation NNS cord-010092-uftc8inx 2109 13 were be VBD cord-010092-uftc8inx 2109 14 detected detect VBN cord-010092-uftc8inx 2109 15 in in IN cord-010092-uftc8inx 2109 16 late late JJ cord-010092-uftc8inx 2109 17 fall fall NN cord-010092-uftc8inx 2109 18 or or CC cord-010092-uftc8inx 2109 19 winter winter NN cord-010092-uftc8inx 2109 20 . . . cord-010092-uftc8inx 2110 1 All all DT cord-010092-uftc8inx 2110 2 13 13 CD cord-010092-uftc8inx 2110 3 ( ( -LRB- cord-010092-uftc8inx 2110 4 100 100 CD cord-010092-uftc8inx 2110 5 % % NN cord-010092-uftc8inx 2110 6 ) ) -RRB- cord-010092-uftc8inx 2110 7 confirmed confirm VBD cord-010092-uftc8inx 2110 8 Babesia Babesia NNP cord-010092-uftc8inx 2110 9 - - HYPH cord-010092-uftc8inx 2110 10 positive positive JJ cord-010092-uftc8inx 2110 11 donations donation NNS cord-010092-uftc8inx 2110 12 were be VBD cord-010092-uftc8inx 2110 13 reactive reactive JJ cord-010092-uftc8inx 2110 14 in in IN cord-010092-uftc8inx 2110 15 MP6 MP6 NNP cord-010092-uftc8inx 2110 16 . . . cord-010092-uftc8inx 2111 1 Serology serology NN cord-010092-uftc8inx 2111 2 results result NNS cord-010092-uftc8inx 2111 3 are be VBP cord-010092-uftc8inx 2111 4 available available JJ cord-010092-uftc8inx 2111 5 for for IN cord-010092-uftc8inx 2111 6 12 12 CD cord-010092-uftc8inx 2111 7 of of IN cord-010092-uftc8inx 2111 8 13 13 CD cord-010092-uftc8inx 2111 9 confirmed confirm VBN cord-010092-uftc8inx 2111 10 - - HYPH cord-010092-uftc8inx 2111 11 positive positive JJ cord-010092-uftc8inx 2111 12 donations donation NNS cord-010092-uftc8inx 2111 13 : : : cord-010092-uftc8inx 2112 1 At at IN cord-010092-uftc8inx 2112 2 index index NN cord-010092-uftc8inx 2112 3 , , , cord-010092-uftc8inx 2112 4 6 6 CD cord-010092-uftc8inx 2112 5 of of IN cord-010092-uftc8inx 2112 6 12 12 CD cord-010092-uftc8inx 2112 7 confirmed confirm VBN cord-010092-uftc8inx 2112 8 Babesia Babesia NNP cord-010092-uftc8inx 2112 9 - - HYPH cord-010092-uftc8inx 2112 10 positive positive JJ cord-010092-uftc8inx 2112 11 donations donation NNS cord-010092-uftc8inx 2112 12 were be VBD cord-010092-uftc8inx 2112 13 only only RB cord-010092-uftc8inx 2112 14 IgG igg NN cord-010092-uftc8inx 2112 15 - - HYPH cord-010092-uftc8inx 2112 16 positive positive JJ cord-010092-uftc8inx 2112 17 , , , cord-010092-uftc8inx 2112 18 while while IN cord-010092-uftc8inx 2112 19 none none NN cord-010092-uftc8inx 2112 20 were be VBD cord-010092-uftc8inx 2112 21 only only RB cord-010092-uftc8inx 2112 22 IgM igm JJ cord-010092-uftc8inx 2112 23 - - HYPH cord-010092-uftc8inx 2112 24 positive positive JJ cord-010092-uftc8inx 2112 25 ; ; : cord-010092-uftc8inx 2112 26 3 3 CD cord-010092-uftc8inx 2112 27 were be VBD cord-010092-uftc8inx 2112 28 positive positive JJ cord-010092-uftc8inx 2112 29 for for IN cord-010092-uftc8inx 2112 30 both both DT cord-010092-uftc8inx 2112 31 IgG igg NN cord-010092-uftc8inx 2112 32 and and CC cord-010092-uftc8inx 2112 33 IgM. IgM. NNP cord-010092-uftc8inx 2112 34 3 3 CD cord-010092-uftc8inx 2112 35 of of IN cord-010092-uftc8inx 2112 36 the the DT cord-010092-uftc8inx 2112 37 confirmed confirm VBN cord-010092-uftc8inx 2112 38 - - HYPH cord-010092-uftc8inx 2112 39 Babesia babesia JJ cord-010092-uftc8inx 2112 40 positive positive JJ cord-010092-uftc8inx 2112 41 donations donation NNS cord-010092-uftc8inx 2112 42 were be VBD cord-010092-uftc8inx 2112 43 negative negative JJ cord-010092-uftc8inx 2112 44 for for IN cord-010092-uftc8inx 2112 45 both both DT cord-010092-uftc8inx 2112 46 IgG IgG NNP cord-010092-uftc8inx 2112 47 and and CC cord-010092-uftc8inx 2112 48 IgM IgM NNP cord-010092-uftc8inx 2112 49 antibodies antibody NNS cord-010092-uftc8inx 2112 50 . . . cord-010092-uftc8inx 2113 1 cobas cobas NNP cord-010092-uftc8inx 2114 1 â â LS cord-010092-uftc8inx 2115 1 Babesia Babesia NNP cord-010092-uftc8inx 2115 2 showed show VBD cord-010092-uftc8inx 2115 3 an an DT cord-010092-uftc8inx 2115 4 overall overall JJ cord-010092-uftc8inx 2115 5 specificity specificity NN cord-010092-uftc8inx 2115 6 of of IN cord-010092-uftc8inx 2115 7 99.999 99.999 CD cord-010092-uftc8inx 2115 8 % % NN cord-010092-uftc8inx 2115 9 ( ( -LRB- cord-010092-uftc8inx 2115 10 256,787/256,789 256,787/256,789 CD cord-010092-uftc8inx 2115 11 ; ; : cord-010092-uftc8inx 2115 12 95 95 CD cord-010092-uftc8inx 2115 13 % % NN cord-010092-uftc8inx 2115 14 Exact Exact NNP cord-010092-uftc8inx 2115 15 CI CI NNP cord-010092-uftc8inx 2115 16 : : : cord-010092-uftc8inx 2115 17 99.997%>100 99.997%>100 CD cord-010092-uftc8inx 2115 18 % % NN cord-010092-uftc8inx 2115 19 ) ) -RRB- cord-010092-uftc8inx 2115 20 . . . cord-010092-uftc8inx 2116 1 Summary Summary NNP cord-010092-uftc8inx 2116 2 / / SYM cord-010092-uftc8inx 2116 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 2116 4 : : : cord-010092-uftc8inx 2117 1 The the DT cord-010092-uftc8inx 2117 2 cobas cobas NNP cord-010092-uftc8inx 2118 1 â â LS cord-010092-uftc8inx 2119 1 Babesia babesia JJ cord-010092-uftc8inx 2119 2 test test NN cord-010092-uftc8inx 2119 3 successfully successfully RB cord-010092-uftc8inx 2119 4 identified identify VBD cord-010092-uftc8inx 2119 5 13 13 CD cord-010092-uftc8inx 2119 6 Babesiapositive Babesiapositive NNP cord-010092-uftc8inx 2119 7 donations donation NNS cord-010092-uftc8inx 2119 8 , , , cord-010092-uftc8inx 2119 9 including include VBG cord-010092-uftc8inx 2119 10 3 3 CD cord-010092-uftc8inx 2119 11 confirmed confirm VBN cord-010092-uftc8inx 2119 12 - - HYPH cord-010092-uftc8inx 2119 13 positive positive JJ cord-010092-uftc8inx 2119 14 donations donation NNS cord-010092-uftc8inx 2119 15 with with IN cord-010092-uftc8inx 2119 16 no no DT cord-010092-uftc8inx 2119 17 IgM IgM NNP cord-010092-uftc8inx 2119 18 or or CC cord-010092-uftc8inx 2119 19 IgG IgG NNP cord-010092-uftc8inx 2119 20 reactivity reactivity NN cord-010092-uftc8inx 2119 21 . . . cord-010092-uftc8inx 2120 1 2 2 CD cord-010092-uftc8inx 2120 2 donations donation NNS cord-010092-uftc8inx 2120 3 were be VBD cord-010092-uftc8inx 2120 4 collected collect VBN cord-010092-uftc8inx 2120 5 in in IN cord-010092-uftc8inx 2120 6 states state NNS cord-010092-uftc8inx 2120 7 considered consider VBN cord-010092-uftc8inx 2120 8 low low JJ cord-010092-uftc8inx 2120 9 - - : cord-010092-uftc8inx 2120 10 or or CC cord-010092-uftc8inx 2120 11 non non JJ cord-010092-uftc8inx 2120 12 - - JJ cord-010092-uftc8inx 2120 13 endemic endemic JJ cord-010092-uftc8inx 2120 14 for for IN cord-010092-uftc8inx 2120 15 Babesia Babesia NNP cord-010092-uftc8inx 2120 16 . . . cord-010092-uftc8inx 2121 1 8 8 CD cord-010092-uftc8inx 2121 2 confirmed confirm VBN cord-010092-uftc8inx 2121 3 - - HYPH cord-010092-uftc8inx 2121 4 positive positive JJ cord-010092-uftc8inx 2121 5 donations donation NNS cord-010092-uftc8inx 2121 6 were be VBD cord-010092-uftc8inx 2121 7 collected collect VBN cord-010092-uftc8inx 2121 8 outside outside RB cord-010092-uftc8inx 2121 9 of of IN cord-010092-uftc8inx 2121 10 the the DT cord-010092-uftc8inx 2121 11 summer summer NN cord-010092-uftc8inx 2121 12 Babesia Babesia NNP cord-010092-uftc8inx 2121 13 season season NN cord-010092-uftc8inx 2121 14 , , , cord-010092-uftc8inx 2121 15 when when WRB cord-010092-uftc8inx 2121 16 most most JJS cord-010092-uftc8inx 2121 17 clinical clinical JJ cord-010092-uftc8inx 2121 18 cases case NNS cord-010092-uftc8inx 2121 19 occur occur VBP cord-010092-uftc8inx 2121 20 . . . cord-010092-uftc8inx 2122 1 Screening screen VBG cord-010092-uftc8inx 2122 2 with with IN cord-010092-uftc8inx 2122 3 cobas cobas NNP cord-010092-uftc8inx 2122 4 â â . cord-010092-uftc8inx 2123 1 Babesia Babesia NNP cord-010092-uftc8inx 2123 2 continues continue VBZ cord-010092-uftc8inx 2123 3 in in IN cord-010092-uftc8inx 2123 4 several several JJ cord-010092-uftc8inx 2123 5 laboratories laboratory NNS cord-010092-uftc8inx 2123 6 . . . cord-010092-uftc8inx 2124 1 cobas cobas NNP cord-010092-uftc8inx 2125 1 â â LS cord-010092-uftc8inx 2126 1 Babesia Babesia NNP cord-010092-uftc8inx 2126 2 is be VBZ cord-010092-uftc8inx 2126 3 not not RB cord-010092-uftc8inx 2126 4 FDA FDA NNP cord-010092-uftc8inx 2126 5 licensed license VBN cord-010092-uftc8inx 2126 6 or or CC cord-010092-uftc8inx 2126 7 available available JJ cord-010092-uftc8inx 2126 8 commercially commercially RB cord-010092-uftc8inx 2126 9 . . . cord-010092-uftc8inx 2127 1 Background background NN cord-010092-uftc8inx 2127 2 : : : cord-010092-uftc8inx 2128 1 Babesiosis babesiosis NN cord-010092-uftc8inx 2128 2 in in IN cord-010092-uftc8inx 2128 3 humans human NNS cord-010092-uftc8inx 2128 4 is be VBZ cord-010092-uftc8inx 2128 5 caused cause VBN cord-010092-uftc8inx 2128 6 by by IN cord-010092-uftc8inx 2128 7 the the DT cord-010092-uftc8inx 2128 8 erythrocytic erythrocytic JJ cord-010092-uftc8inx 2128 9 protozoan protozoan NN cord-010092-uftc8inx 2128 10 parasite parasite NN cord-010092-uftc8inx 2128 11 , , , cord-010092-uftc8inx 2128 12 Babesia Babesia NNP cord-010092-uftc8inx 2128 13 microti microti NN cord-010092-uftc8inx 2128 14 which which WDT cord-010092-uftc8inx 2128 15 is be VBZ cord-010092-uftc8inx 2128 16 transmitted transmit VBN cord-010092-uftc8inx 2128 17 by by IN cord-010092-uftc8inx 2128 18 tick tick NN cord-010092-uftc8inx 2128 19 bites bite NNS cord-010092-uftc8inx 2128 20 , , , cord-010092-uftc8inx 2128 21 but but CC cord-010092-uftc8inx 2128 22 is be VBZ cord-010092-uftc8inx 2128 23 also also RB cord-010092-uftc8inx 2128 24 transfusion transfusion NN cord-010092-uftc8inx 2128 25 transmitted transmit VBN cord-010092-uftc8inx 2128 26 . . . cord-010092-uftc8inx 2129 1 Although although IN cord-010092-uftc8inx 2129 2 frequently frequently RB cord-010092-uftc8inx 2129 3 asymptomatic asymptomatic JJ cord-010092-uftc8inx 2129 4 or or CC cord-010092-uftc8inx 2129 5 presenting present VBG cord-010092-uftc8inx 2129 6 with with IN cord-010092-uftc8inx 2129 7 flu flu NN cord-010092-uftc8inx 2129 8 - - HYPH cord-010092-uftc8inx 2129 9 like like JJ cord-010092-uftc8inx 2129 10 symptoms symptom NNS cord-010092-uftc8inx 2129 11 in in IN cord-010092-uftc8inx 2129 12 a a DT cord-010092-uftc8inx 2129 13 normal normal JJ cord-010092-uftc8inx 2129 14 host host NN cord-010092-uftc8inx 2129 15 , , , cord-010092-uftc8inx 2129 16 if if IN cord-010092-uftc8inx 2129 17 immunocompromised immunocompromised JJ cord-010092-uftc8inx 2129 18 infection infection NN cord-010092-uftc8inx 2129 19 can can MD cord-010092-uftc8inx 2129 20 lead lead VB cord-010092-uftc8inx 2129 21 to to IN cord-010092-uftc8inx 2129 22 severe severe JJ cord-010092-uftc8inx 2129 23 complications complication NNS cord-010092-uftc8inx 2129 24 and and CC cord-010092-uftc8inx 2129 25 death death NN cord-010092-uftc8inx 2129 26 . . . cord-010092-uftc8inx 2130 1 B. B. NNP cord-010092-uftc8inx 2130 2 microti microti NNP cord-010092-uftc8inx 2130 3 is be VBZ cord-010092-uftc8inx 2130 4 endemic endemic JJ cord-010092-uftc8inx 2130 5 in in IN cord-010092-uftc8inx 2130 6 the the DT cord-010092-uftc8inx 2130 7 North North NNP cord-010092-uftc8inx 2130 8 Eastern Eastern NNP cord-010092-uftc8inx 2130 9 / / SYM cord-010092-uftc8inx 2130 10 Upper Upper NNP cord-010092-uftc8inx 2130 11 Midwest Midwest NNP cord-010092-uftc8inx 2130 12 United United NNP cord-010092-uftc8inx 2130 13 States States NNP cord-010092-uftc8inx 2130 14 where where WRB cord-010092-uftc8inx 2130 15 partial partial JJ cord-010092-uftc8inx 2130 16 testing testing NN cord-010092-uftc8inx 2130 17 of of IN cord-010092-uftc8inx 2130 18 donations donation NNS cord-010092-uftc8inx 2130 19 has have VBZ cord-010092-uftc8inx 2130 20 been be VBN cord-010092-uftc8inx 2130 21 implemented implement VBN cord-010092-uftc8inx 2130 22 . . . cord-010092-uftc8inx 2131 1 In in IN cord-010092-uftc8inx 2131 2 Canada Canada NNP cord-010092-uftc8inx 2131 3 , , , cord-010092-uftc8inx 2131 4 a a DT cord-010092-uftc8inx 2131 5 2013 2013 CD cord-010092-uftc8inx 2131 6 study study NN cord-010092-uftc8inx 2131 7 of~14,000 of~14,000 CD cord-010092-uftc8inx 2131 8 donors donor NNS cord-010092-uftc8inx 2131 9 did do VBD cord-010092-uftc8inx 2131 10 not not RB cord-010092-uftc8inx 2131 11 identify identify VB cord-010092-uftc8inx 2131 12 any any DT cord-010092-uftc8inx 2131 13 B. B. NNP cord-010092-uftc8inx 2131 14 microti microti NN cord-010092-uftc8inx 2131 15 antibody antibody NN cord-010092-uftc8inx 2131 16 - - HYPH cord-010092-uftc8inx 2131 17 positive positive JJ cord-010092-uftc8inx 2131 18 samples sample NNS cord-010092-uftc8inx 2131 19 , , , cord-010092-uftc8inx 2131 20 suggesting suggest VBG cord-010092-uftc8inx 2131 21 low low JJ cord-010092-uftc8inx 2131 22 risk risk NN cord-010092-uftc8inx 2131 23 at at IN cord-010092-uftc8inx 2131 24 that that DT cord-010092-uftc8inx 2131 25 time time NN cord-010092-uftc8inx 2131 26 , , , cord-010092-uftc8inx 2131 27 but but CC cord-010092-uftc8inx 2131 28 risk risk NN cord-010092-uftc8inx 2131 29 should should MD cord-010092-uftc8inx 2131 30 be be VB cord-010092-uftc8inx 2131 31 monitored monitor VBN cord-010092-uftc8inx 2131 32 . . . cord-010092-uftc8inx 2132 1 Aims aim VBZ cord-010092-uftc8inx 2132 2 : : : cord-010092-uftc8inx 2132 3 To to TO cord-010092-uftc8inx 2132 4 evaluate evaluate VB cord-010092-uftc8inx 2132 5 the the DT cord-010092-uftc8inx 2132 6 prevalence prevalence NN cord-010092-uftc8inx 2132 7 of of IN cord-010092-uftc8inx 2132 8 B. B. NNP cord-010092-uftc8inx 2132 9 microti microti JJ cord-010092-uftc8inx 2132 10 - - HYPH cord-010092-uftc8inx 2132 11 positive positive JJ cord-010092-uftc8inx 2132 12 donations donation NNS cord-010092-uftc8inx 2132 13 in in IN cord-010092-uftc8inx 2132 14 potentially potentially RB cord-010092-uftc8inx 2132 15 atrisk atrisk VBN cord-010092-uftc8inx 2132 16 areas area NNS cord-010092-uftc8inx 2132 17 in in IN cord-010092-uftc8inx 2132 18 Canada Canada NNP cord-010092-uftc8inx 2132 19 . . . cord-010092-uftc8inx 2133 1 Methods method NNS cord-010092-uftc8inx 2133 2 : : : cord-010092-uftc8inx 2133 3 Between between IN cord-010092-uftc8inx 2133 4 July July NNP cord-010092-uftc8inx 2133 5 and and CC cord-010092-uftc8inx 2133 6 November November NNP cord-010092-uftc8inx 2133 7 2018 2018 CD cord-010092-uftc8inx 2133 8 , , , cord-010092-uftc8inx 2133 9 50,752 50,752 CD cord-010092-uftc8inx 2133 10 blood blood NN cord-010092-uftc8inx 2133 11 donor donor NN cord-010092-uftc8inx 2133 12 samples sample NNS cord-010092-uftc8inx 2133 13 were be VBD cord-010092-uftc8inx 2133 14 selected select VBN cord-010092-uftc8inx 2133 15 from from IN cord-010092-uftc8inx 2133 16 sites site NNS cord-010092-uftc8inx 2133 17 near near IN cord-010092-uftc8inx 2133 18 the the DT cord-010092-uftc8inx 2133 19 US US NNP cord-010092-uftc8inx 2133 20 border border NN cord-010092-uftc8inx 2133 21 . . . cord-010092-uftc8inx 2134 1 Minipools minipool NNS cord-010092-uftc8inx 2134 2 were be VBD cord-010092-uftc8inx 2134 3 tested test VBN cord-010092-uftc8inx 2134 4 for for IN cord-010092-uftc8inx 2134 5 B. B. NNP cord-010092-uftc8inx 2134 6 microti microti NN cord-010092-uftc8inx 2134 7 nucleic nucleic JJ cord-010092-uftc8inx 2134 8 acid acid NN cord-010092-uftc8inx 2134 9 by by IN cord-010092-uftc8inx 2135 1 Transcription transcription NN cord-010092-uftc8inx 2135 2 Mediated mediate VBN cord-010092-uftc8inx 2135 3 Amplification Amplification NNP cord-010092-uftc8inx 2135 4 ( ( -LRB- cord-010092-uftc8inx 2135 5 TMA TMA NNP cord-010092-uftc8inx 2135 6 ) ) -RRB- cord-010092-uftc8inx 2135 7 using use VBG cord-010092-uftc8inx 2135 8 the the DT cord-010092-uftc8inx 2135 9 Procleix Procleix NNP cord-010092-uftc8inx 2135 10 â â NN cord-010092-uftc8inx 2135 11 Babesia Babesia NNP cord-010092-uftc8inx 2135 12 Assay Assay NNP cord-010092-uftc8inx 2135 13 on on IN cord-010092-uftc8inx 2135 14 the the DT cord-010092-uftc8inx 2135 15 Panther Panther NNP cord-010092-uftc8inx 2135 16 â â , cord-010092-uftc8inx 2135 17 system system NN cord-010092-uftc8inx 2135 18 with with IN cord-010092-uftc8inx 2135 19 individual individual JJ cord-010092-uftc8inx 2135 20 testing testing NN cord-010092-uftc8inx 2135 21 on on IN cord-010092-uftc8inx 2135 22 reactive reactive JJ cord-010092-uftc8inx 2135 23 pools pool NNS cord-010092-uftc8inx 2135 24 . . . cord-010092-uftc8inx 2136 1 Reactive reactive JJ cord-010092-uftc8inx 2136 2 donations donation NNS cord-010092-uftc8inx 2136 3 were be VBD cord-010092-uftc8inx 2136 4 also also RB cord-010092-uftc8inx 2136 5 tested test VBN cord-010092-uftc8inx 2136 6 by by IN cord-010092-uftc8inx 2136 7 B. B. NNP cord-010092-uftc8inx 2136 8 microti microti NN cord-010092-uftc8inx 2136 9 - - HYPH cord-010092-uftc8inx 2136 10 specific specific JJ cord-010092-uftc8inx 2136 11 : : : cord-010092-uftc8inx 2136 12 American American NNP cord-010092-uftc8inx 2136 13 Red Red NNP cord-010092-uftc8inx 2136 14 Cross Cross NNP cord-010092-uftc8inx 2136 15 ( ( -LRB- cord-010092-uftc8inx 2136 16 ARC ARC NNP cord-010092-uftc8inx 2136 17 ) ) -RRB- cord-010092-uftc8inx 2136 18 IgG igg NN cord-010092-uftc8inx 2136 19 immunofluorescence immunofluorescence NN cord-010092-uftc8inx 2136 20 assay assay NN cord-010092-uftc8inx 2136 21 [ [ -LRB- cord-010092-uftc8inx 2136 22 IFA IFA NNP cord-010092-uftc8inx 2136 23 ] ] -RRB- cord-010092-uftc8inx 2136 24 and and CC cord-010092-uftc8inx 2136 25 IMUGEN IMUGEN NNP cord-010092-uftc8inx 2136 26 IFA IFA NNP cord-010092-uftc8inx 2136 27 / / SYM cord-010092-uftc8inx 2136 28 PCR PCR NNP cord-010092-uftc8inx 2136 29 . . . cord-010092-uftc8inx 2137 1 A a DT cord-010092-uftc8inx 2137 2 subset subset NN cord-010092-uftc8inx 2137 3 of of IN cord-010092-uftc8inx 2137 4 14,758 14,758 CD cord-010092-uftc8inx 2137 5 TMA TMA NNP cord-010092-uftc8inx 2137 6 - - HYPH cord-010092-uftc8inx 2137 7 negative negative JJ cord-010092-uftc8inx 2137 8 samples sample NNS cord-010092-uftc8inx 2137 9 , , , cord-010092-uftc8inx 2137 10 primarily primarily RB cord-010092-uftc8inx 2137 11 from from IN cord-010092-uftc8inx 2137 12 the the DT cord-010092-uftc8inx 2137 13 province province NN cord-010092-uftc8inx 2137 14 of of IN cord-010092-uftc8inx 2137 15 Manitoba Manitoba NNP cord-010092-uftc8inx 2137 16 and and CC cord-010092-uftc8inx 2137 17 eastwards eastwards RB cord-010092-uftc8inx 2137 18 to to IN cord-010092-uftc8inx 2137 19 Nova Nova NNP cord-010092-uftc8inx 2137 20 Scotia Scotia NNP cord-010092-uftc8inx 2137 21 , , , cord-010092-uftc8inx 2137 22 were be VBD cord-010092-uftc8inx 2137 23 tested test VBN cord-010092-uftc8inx 2137 24 for for IN cord-010092-uftc8inx 2137 25 B. B. NNP cord-010092-uftc8inx 2137 26 microti microti NN cord-010092-uftc8inx 2137 27 antibody antibody NN cord-010092-uftc8inx 2137 28 using use VBG cord-010092-uftc8inx 2137 29 the the DT cord-010092-uftc8inx 2137 30 ARC ARC NNP cord-010092-uftc8inx 2137 31 IFA IFA NNP cord-010092-uftc8inx 2137 32 and and CC cord-010092-uftc8inx 2137 33 if if IN cord-010092-uftc8inx 2137 34 positive positive JJ cord-010092-uftc8inx 2137 35 , , , cord-010092-uftc8inx 2137 36 the the DT cord-010092-uftc8inx 2137 37 IMUGEN IMUGEN NNP cord-010092-uftc8inx 2137 38 IFA IFA NNP cord-010092-uftc8inx 2137 39 / / SYM cord-010092-uftc8inx 2137 40 PCR PCR NNP cord-010092-uftc8inx 2137 41 . . . cord-010092-uftc8inx 2138 1 Donor donor NN cord-010092-uftc8inx 2138 2 age age NN cord-010092-uftc8inx 2138 3 , , , cord-010092-uftc8inx 2138 4 sex sex NN cord-010092-uftc8inx 2138 5 , , , cord-010092-uftc8inx 2138 6 donation donation NN cord-010092-uftc8inx 2138 7 status status NN cord-010092-uftc8inx 2138 8 , , , cord-010092-uftc8inx 2138 9 residential residential JJ cord-010092-uftc8inx 2138 10 location location NN cord-010092-uftc8inx 2138 11 and and CC cord-010092-uftc8inx 2138 12 collection collection NN cord-010092-uftc8inx 2138 13 site site NN cord-010092-uftc8inx 2138 14 location location NN cord-010092-uftc8inx 2138 15 were be VBD cord-010092-uftc8inx 2138 16 recorded record VBN cord-010092-uftc8inx 2138 17 . . . cord-010092-uftc8inx 2139 1 Donors donor NNS cord-010092-uftc8inx 2139 2 who who WP cord-010092-uftc8inx 2139 3 tested test VBD cord-010092-uftc8inx 2139 4 reactive reactive JJ cord-010092-uftc8inx 2139 5 / / SYM cord-010092-uftc8inx 2139 6 positive positive JJ cord-010092-uftc8inx 2139 7 were be VBD cord-010092-uftc8inx 2139 8 informed inform VBN cord-010092-uftc8inx 2139 9 , , , cord-010092-uftc8inx 2139 10 deferred defer VBN cord-010092-uftc8inx 2139 11 and and CC cord-010092-uftc8inx 2139 12 asked ask VBD cord-010092-uftc8inx 2139 13 about about IN cord-010092-uftc8inx 2139 14 risk risk NN cord-010092-uftc8inx 2139 15 factors factor NNS cord-010092-uftc8inx 2139 16 ( ( -LRB- cord-010092-uftc8inx 2139 17 possible possible JJ cord-010092-uftc8inx 2139 18 tick tick NN cord-010092-uftc8inx 2139 19 exposure exposure NN cord-010092-uftc8inx 2139 20 and and CC cord-010092-uftc8inx 2139 21 travel travel NN cord-010092-uftc8inx 2139 22 within within IN cord-010092-uftc8inx 2139 23 Canada Canada NNP cord-010092-uftc8inx 2139 24 , , , cord-010092-uftc8inx 2139 25 the the DT cord-010092-uftc8inx 2139 26 USA USA NNP cord-010092-uftc8inx 2139 27 and and CC cord-010092-uftc8inx 2139 28 elsewhere elsewhere RB cord-010092-uftc8inx 2139 29 , , , cord-010092-uftc8inx 2139 30 history history NN cord-010092-uftc8inx 2139 31 of of IN cord-010092-uftc8inx 2139 32 symptoms symptom NNS cord-010092-uftc8inx 2139 33 ) ) -RRB- cord-010092-uftc8inx 2139 34 and and CC cord-010092-uftc8inx 2139 35 a a DT cord-010092-uftc8inx 2139 36 follow follow VB cord-010092-uftc8inx 2139 37 - - HYPH cord-010092-uftc8inx 2139 38 up up RP cord-010092-uftc8inx 2139 39 sample sample NN cord-010092-uftc8inx 2139 40 was be VBD cord-010092-uftc8inx 2139 41 requested request VBN cord-010092-uftc8inx 2139 42 for for IN cord-010092-uftc8inx 2139 43 supplemental supplemental JJ cord-010092-uftc8inx 2139 44 testing testing NN cord-010092-uftc8inx 2139 45 ( ( -LRB- cord-010092-uftc8inx 2139 46 TMA TMA NNP cord-010092-uftc8inx 2139 47 , , , cord-010092-uftc8inx 2139 48 ARC ARC NNP cord-010092-uftc8inx 2139 49 IFA IFA NNP cord-010092-uftc8inx 2139 50 ) ) -RRB- cord-010092-uftc8inx 2139 51 . . . cord-010092-uftc8inx 2140 1 Reactive reactive JJ cord-010092-uftc8inx 2140 2 donations donation NNS cord-010092-uftc8inx 2140 3 were be VBD cord-010092-uftc8inx 2140 4 removed remove VBN cord-010092-uftc8inx 2140 5 from from IN cord-010092-uftc8inx 2140 6 inventory inventory NN cord-010092-uftc8inx 2140 7 . . . cord-010092-uftc8inx 2141 1 Results result NNS cord-010092-uftc8inx 2141 2 : : : cord-010092-uftc8inx 2142 1 The the DT cord-010092-uftc8inx 2142 2 50,752 50,752 CD cord-010092-uftc8inx 2142 3 donor donor NN cord-010092-uftc8inx 2142 4 samples sample NNS cord-010092-uftc8inx 2142 5 were be VBD cord-010092-uftc8inx 2142 6 proportional proportional JJ cord-010092-uftc8inx 2142 7 to to IN cord-010092-uftc8inx 2142 8 collections collection NNS cord-010092-uftc8inx 2142 9 in in IN cord-010092-uftc8inx 2142 10 target target NN cord-010092-uftc8inx 2142 11 geographic geographic JJ cord-010092-uftc8inx 2142 12 regions region NNS cord-010092-uftc8inx 2142 13 . . . cord-010092-uftc8inx 2143 1 Age age NN cord-010092-uftc8inx 2143 2 group group NN cord-010092-uftc8inx 2143 3 , , , cord-010092-uftc8inx 2143 4 sex sex NN cord-010092-uftc8inx 2143 5 and and CC cord-010092-uftc8inx 2143 6 donation donation NN cord-010092-uftc8inx 2143 7 status status NN cord-010092-uftc8inx 2143 8 were be VBD cord-010092-uftc8inx 2143 9 also also RB cord-010092-uftc8inx 2143 10 similar similar JJ cord-010092-uftc8inx 2143 11 to to IN cord-010092-uftc8inx 2143 12 the the DT cord-010092-uftc8inx 2143 13 donor donor NN cord-010092-uftc8inx 2143 14 base base NN cord-010092-uftc8inx 2143 15 in in IN cord-010092-uftc8inx 2143 16 the the DT cord-010092-uftc8inx 2143 17 collection collection NN cord-010092-uftc8inx 2143 18 areas area NNS cord-010092-uftc8inx 2143 19 . . . cord-010092-uftc8inx 2144 1 One one CD cord-010092-uftc8inx 2144 2 sample sample NN cord-010092-uftc8inx 2144 3 from from IN cord-010092-uftc8inx 2144 4 Winnipeg Winnipeg NNP cord-010092-uftc8inx 2144 5 , , , cord-010092-uftc8inx 2144 6 Manitoba Manitoba NNP cord-010092-uftc8inx 2144 7 was be VBD cord-010092-uftc8inx 2144 8 TMA TMA NNP cord-010092-uftc8inx 2144 9 reactive reactive JJ cord-010092-uftc8inx 2144 10 and and CC cord-010092-uftc8inx 2144 11 antibody antibody NN cord-010092-uftc8inx 2144 12 positive positive JJ cord-010092-uftc8inx 2144 13 on on IN cord-010092-uftc8inx 2144 14 supplementary supplementary JJ cord-010092-uftc8inx 2144 15 testing testing NN cord-010092-uftc8inx 2144 16 . . . cord-010092-uftc8inx 2145 1 The the DT cord-010092-uftc8inx 2145 2 donor donor NN cord-010092-uftc8inx 2145 3 did do VBD cord-010092-uftc8inx 2145 4 not not RB cord-010092-uftc8inx 2145 5 remember remember VB cord-010092-uftc8inx 2145 6 symptoms symptom NNS cord-010092-uftc8inx 2145 7 or or CC cord-010092-uftc8inx 2145 8 spending spend VBG cord-010092-uftc8inx 2145 9 time time NN cord-010092-uftc8inx 2145 10 in in IN cord-010092-uftc8inx 2145 11 wooded wooded JJ cord-010092-uftc8inx 2145 12 areas area NNS cord-010092-uftc8inx 2145 13 . . . cord-010092-uftc8inx 2146 1 He -PRON- PRP cord-010092-uftc8inx 2146 2 visited visit VBD cord-010092-uftc8inx 2146 3 the the DT cord-010092-uftc8inx 2146 4 city city NN cord-010092-uftc8inx 2146 5 of of IN cord-010092-uftc8inx 2146 6 Fargo Fargo NNP cord-010092-uftc8inx 2146 7 , , , cord-010092-uftc8inx 2146 8 North North NNP cord-010092-uftc8inx 2146 9 Dakota Dakota NNP cord-010092-uftc8inx 2146 10 , , , cord-010092-uftc8inx 2146 11 USA USA NNP cord-010092-uftc8inx 2146 12 . . . cord-010092-uftc8inx 2147 1 The the DT cord-010092-uftc8inx 2147 2 subset subset NN cord-010092-uftc8inx 2147 3 of of IN cord-010092-uftc8inx 2147 4 14,758 14,758 CD cord-010092-uftc8inx 2147 5 samples sample NNS cord-010092-uftc8inx 2147 6 tested test VBN cord-010092-uftc8inx 2147 7 for for IN cord-010092-uftc8inx 2147 8 antibody antibody NN cord-010092-uftc8inx 2147 9 were be VBD cord-010092-uftc8inx 2147 10 also also RB cord-010092-uftc8inx 2147 11 proportional proportional JJ cord-010092-uftc8inx 2147 12 to to IN cord-010092-uftc8inx 2147 13 collections collection NNS cord-010092-uftc8inx 2147 14 in in IN cord-010092-uftc8inx 2147 15 the the DT cord-010092-uftc8inx 2147 16 targeted target VBN cord-010092-uftc8inx 2147 17 areas area NNS cord-010092-uftc8inx 2147 18 . . . cord-010092-uftc8inx 2148 1 Four four CD cord-010092-uftc8inx 2148 2 antibody antibody NN cord-010092-uftc8inx 2148 3 - - HYPH cord-010092-uftc8inx 2148 4 positive positive JJ cord-010092-uftc8inx 2148 5 samples sample NNS cord-010092-uftc8inx 2148 6 were be VBD cord-010092-uftc8inx 2148 7 identified identify VBN cord-010092-uftc8inx 2148 8 from from IN cord-010092-uftc8inx 2148 9 mid mid NNP cord-010092-uftc8inx 2148 10 - - NNP cord-010092-uftc8inx 2148 11 September September NNP cord-010092-uftc8inx 2148 12 to to IN cord-010092-uftc8inx 2148 13 October October NNP cord-010092-uftc8inx 2148 14 1 1 CD cord-010092-uftc8inx 2148 15 , , , cord-010092-uftc8inx 2148 16 all all DT cord-010092-uftc8inx 2148 17 in in IN cord-010092-uftc8inx 2148 18 south south JJ cord-010092-uftc8inx 2148 19 western western JJ cord-010092-uftc8inx 2148 20 Ontario Ontario NNP cord-010092-uftc8inx 2148 21 near near IN cord-010092-uftc8inx 2148 22 Lake Lake NNP cord-010092-uftc8inx 2148 23 Erie Erie NNP cord-010092-uftc8inx 2148 24 . . . cord-010092-uftc8inx 2149 1 None none NN cord-010092-uftc8inx 2149 2 were be VBD cord-010092-uftc8inx 2149 3 TMA TMA NNP cord-010092-uftc8inx 2149 4 reactive reactive JJ cord-010092-uftc8inx 2149 5 . . . cord-010092-uftc8inx 2150 1 Three three CD cord-010092-uftc8inx 2150 2 were be VBD cord-010092-uftc8inx 2150 3 interviewed interview VBN cord-010092-uftc8inx 2150 4 and and CC cord-010092-uftc8inx 2150 5 none none NN cord-010092-uftc8inx 2150 6 remembered remember VBD cord-010092-uftc8inx 2150 7 any any DT cord-010092-uftc8inx 2150 8 symptoms symptom NNS cord-010092-uftc8inx 2150 9 , , , cord-010092-uftc8inx 2150 10 any any DT cord-010092-uftc8inx 2150 11 likely likely JJ cord-010092-uftc8inx 2150 12 tick tick NN cord-010092-uftc8inx 2150 13 exposure exposure NN cord-010092-uftc8inx 2150 14 , , , cord-010092-uftc8inx 2150 15 or or CC cord-010092-uftc8inx 2150 16 relevant relevant JJ cord-010092-uftc8inx 2150 17 travel travel NN cord-010092-uftc8inx 2150 18 within within IN cord-010092-uftc8inx 2150 19 Canada Canada NNP cord-010092-uftc8inx 2150 20 or or CC cord-010092-uftc8inx 2150 21 the the DT cord-010092-uftc8inx 2150 22 USA USA NNP cord-010092-uftc8inx 2150 23 . . . cord-010092-uftc8inx 2151 1 Summary Summary NNP cord-010092-uftc8inx 2151 2 / / SYM cord-010092-uftc8inx 2151 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 2151 4 : : : cord-010092-uftc8inx 2152 1 This this DT cord-010092-uftc8inx 2152 2 is be VBZ cord-010092-uftc8inx 2152 3 the the DT cord-010092-uftc8inx 2152 4 largest large JJS cord-010092-uftc8inx 2152 5 B. B. NNP cord-010092-uftc8inx 2152 6 microti microti NN cord-010092-uftc8inx 2152 7 prevalence prevalence NN cord-010092-uftc8inx 2152 8 study study NN cord-010092-uftc8inx 2152 9 in in IN cord-010092-uftc8inx 2152 10 Canada Canada NNP cord-010092-uftc8inx 2152 11 . . . cord-010092-uftc8inx 2153 1 The the DT cord-010092-uftc8inx 2153 2 results result NNS cord-010092-uftc8inx 2153 3 indicate indicate VBP cord-010092-uftc8inx 2153 4 very very RB cord-010092-uftc8inx 2153 5 low low JJ cord-010092-uftc8inx 2153 6 prevalence prevalence NN cord-010092-uftc8inx 2153 7 with with IN cord-010092-uftc8inx 2153 8 only only RB cord-010092-uftc8inx 2153 9 1 1 CD cord-010092-uftc8inx 2153 10 TMA TMA NNP cord-010092-uftc8inx 2153 11 - - HYPH cord-010092-uftc8inx 2153 12 confirmed confirm VBN cord-010092-uftc8inx 2153 13 - - HYPH cord-010092-uftc8inx 2153 14 positive positive JJ cord-010092-uftc8inx 2153 15 donation donation NN cord-010092-uftc8inx 2153 16 of of IN cord-010092-uftc8inx 2153 17 50,752 50,752 CD cord-010092-uftc8inx 2153 18 tested test VBN cord-010092-uftc8inx 2153 19 . . . cord-010092-uftc8inx 2154 1 The the DT cord-010092-uftc8inx 2154 2 donor donor NN cord-010092-uftc8inx 2154 3 was be VBD cord-010092-uftc8inx 2154 4 from from IN cord-010092-uftc8inx 2154 5 the the DT cord-010092-uftc8inx 2154 6 only only JJ cord-010092-uftc8inx 2154 7 region region NN cord-010092-uftc8inx 2154 8 in in IN cord-010092-uftc8inx 2154 9 Canada Canada NNP cord-010092-uftc8inx 2154 10 where where WRB cord-010092-uftc8inx 2154 11 one one CD cord-010092-uftc8inx 2154 12 autochthonous autochthonous JJ cord-010092-uftc8inx 2154 13 human human JJ cord-010092-uftc8inx 2154 14 case case NN cord-010092-uftc8inx 2154 15 has have VBZ cord-010092-uftc8inx 2154 16 been be VBN cord-010092-uftc8inx 2154 17 reported report VBN cord-010092-uftc8inx 2154 18 and and CC cord-010092-uftc8inx 2154 19 active active JJ cord-010092-uftc8inx 2154 20 tick tick NN cord-010092-uftc8inx 2154 21 surveillance surveillance NN cord-010092-uftc8inx 2154 22 identified identify VBD cord-010092-uftc8inx 2154 23 B. B. NNP cord-010092-uftc8inx 2154 24 microti microti NN cord-010092-uftc8inx 2154 25 positive positive JJ cord-010092-uftc8inx 2154 26 tick tick NN cord-010092-uftc8inx 2154 27 populations population NNS cord-010092-uftc8inx 2154 28 . . . cord-010092-uftc8inx 2155 1 Seropositive seropositive JJ cord-010092-uftc8inx 2155 2 donations donation NNS cord-010092-uftc8inx 2155 3 in in IN cord-010092-uftc8inx 2155 4 south south JJ cord-010092-uftc8inx 2155 5 western western JJ cord-010092-uftc8inx 2155 6 Ontario Ontario NNP cord-010092-uftc8inx 2155 7 may may MD cord-010092-uftc8inx 2155 8 suggest suggest VB cord-010092-uftc8inx 2155 9 low low JJ cord-010092-uftc8inx 2155 10 prevalence prevalence NN cord-010092-uftc8inx 2155 11 in in IN cord-010092-uftc8inx 2155 12 that that DT cord-010092-uftc8inx 2155 13 region region NN cord-010092-uftc8inx 2155 14 , , , cord-010092-uftc8inx 2155 15 but but CC cord-010092-uftc8inx 2155 16 interpretation interpretation NN cord-010092-uftc8inx 2155 17 is be VBZ cord-010092-uftc8inx 2155 18 less less RBR cord-010092-uftc8inx 2155 19 certain certain JJ cord-010092-uftc8inx 2155 20 due due IN cord-010092-uftc8inx 2155 21 to to IN cord-010092-uftc8inx 2155 22 lack lack NN cord-010092-uftc8inx 2155 23 of of IN cord-010092-uftc8inx 2155 24 corroborating corroborate VBG cord-010092-uftc8inx 2155 25 supplementary supplementary JJ cord-010092-uftc8inx 2155 26 results result NNS cord-010092-uftc8inx 2155 27 or or CC cord-010092-uftc8inx 2155 28 case case NN cord-010092-uftc8inx 2155 29 history history NN cord-010092-uftc8inx 2155 30 . . . cord-010092-uftc8inx 2156 1 Given give VBN cord-010092-uftc8inx 2156 2 the the DT cord-010092-uftc8inx 2156 3 close close JJ cord-010092-uftc8inx 2156 4 proximity proximity NN cord-010092-uftc8inx 2156 5 to to IN cord-010092-uftc8inx 2156 6 the the DT cord-010092-uftc8inx 2156 7 US US NNP cord-010092-uftc8inx 2156 8 border border NN cord-010092-uftc8inx 2156 9 , , , cord-010092-uftc8inx 2156 10 forgotten forget VBN cord-010092-uftc8inx 2156 11 US US NNP cord-010092-uftc8inx 2156 12 travel travel NN cord-010092-uftc8inx 2156 13 should should MD cord-010092-uftc8inx 2156 14 not not RB cord-010092-uftc8inx 2156 15 be be VB cord-010092-uftc8inx 2156 16 ruled rule VBN cord-010092-uftc8inx 2156 17 out out RP cord-010092-uftc8inx 2156 18 . . . cord-010092-uftc8inx 2157 1 4A 4a LS cord-010092-uftc8inx 2157 2 - - : cord-010092-uftc8inx 2157 3 S18 S18 NNP cord-010092-uftc8inx 2157 4 - - HYPH cord-010092-uftc8inx 2157 5 04 04 CD cord-010092-uftc8inx 2157 6 Background Background NNP cord-010092-uftc8inx 2157 7 : : : cord-010092-uftc8inx 2158 1 The the DT cord-010092-uftc8inx 2158 2 protozoan protozoan NN cord-010092-uftc8inx 2158 3 parasite parasite VBP cord-010092-uftc8inx 2158 4 Toxoplasma toxoplasma NN cord-010092-uftc8inx 2158 5 gondii gondii NN cord-010092-uftc8inx 2158 6 is be VBZ cord-010092-uftc8inx 2158 7 prevalent prevalent JJ cord-010092-uftc8inx 2158 8 in in IN cord-010092-uftc8inx 2158 9 animals animal NNS cord-010092-uftc8inx 2158 10 and and CC cord-010092-uftc8inx 2158 11 humans human NNS cord-010092-uftc8inx 2158 12 worldwide worldwide RB cord-010092-uftc8inx 2158 13 . . . cord-010092-uftc8inx 2159 1 Wild wild JJ cord-010092-uftc8inx 2159 2 and and CC cord-010092-uftc8inx 2159 3 domestic domestic JJ cord-010092-uftc8inx 2159 4 felids felid NNS cord-010092-uftc8inx 2159 5 are be VBP cord-010092-uftc8inx 2159 6 the the DT cord-010092-uftc8inx 2159 7 definitive definitive JJ cord-010092-uftc8inx 2159 8 hosts host NNS cord-010092-uftc8inx 2159 9 , , , cord-010092-uftc8inx 2159 10 and and CC cord-010092-uftc8inx 2159 11 homoeothermic homoeothermic NN cord-010092-uftc8inx 2159 12 animals animal NNS cord-010092-uftc8inx 2159 13 serve serve VBP cord-010092-uftc8inx 2159 14 as as IN cord-010092-uftc8inx 2159 15 the the DT cord-010092-uftc8inx 2159 16 intermediate intermediate JJ cord-010092-uftc8inx 2159 17 ones one NNS cord-010092-uftc8inx 2159 18 . . . cord-010092-uftc8inx 2160 1 After after IN cord-010092-uftc8inx 2160 2 primary primary JJ cord-010092-uftc8inx 2160 3 infection infection NN cord-010092-uftc8inx 2160 4 , , , cord-010092-uftc8inx 2160 5 the the DT cord-010092-uftc8inx 2160 6 parasite parasite NN cord-010092-uftc8inx 2160 7 persists persist VBZ cord-010092-uftc8inx 2160 8 lifelong lifelong JJ cord-010092-uftc8inx 2160 9 within within IN cord-010092-uftc8inx 2160 10 latent latent JJ cord-010092-uftc8inx 2160 11 tissue tissue NN cord-010092-uftc8inx 2160 12 cysts cyst NNS cord-010092-uftc8inx 2160 13 . . . cord-010092-uftc8inx 2161 1 Transmission transmission NN cord-010092-uftc8inx 2161 2 is be VBZ cord-010092-uftc8inx 2161 3 by by IN cord-010092-uftc8inx 2161 4 ingestion ingestion NN cord-010092-uftc8inx 2161 5 of of IN cord-010092-uftc8inx 2161 6 undercooked undercooked JJ cord-010092-uftc8inx 2161 7 or or CC cord-010092-uftc8inx 2161 8 raw raw JJ cord-010092-uftc8inx 2161 9 meat meat NN cord-010092-uftc8inx 2161 10 infected infect VBN cord-010092-uftc8inx 2161 11 with with IN cord-010092-uftc8inx 2161 12 cysts cyst NNS cord-010092-uftc8inx 2161 13 , , , cord-010092-uftc8inx 2161 14 by by IN cord-010092-uftc8inx 2161 15 ingestion ingestion NN cord-010092-uftc8inx 2161 16 of of IN cord-010092-uftc8inx 2161 17 food food NN cord-010092-uftc8inx 2161 18 or or CC cord-010092-uftc8inx 2161 19 water water NN cord-010092-uftc8inx 2161 20 contaminated contaminate VBN cord-010092-uftc8inx 2161 21 with with IN cord-010092-uftc8inx 2161 22 oocysts oocyst NNS cord-010092-uftc8inx 2161 23 , , , cord-010092-uftc8inx 2161 24 or or CC cord-010092-uftc8inx 2161 25 transplacentally transplacentally NN cord-010092-uftc8inx 2161 26 . . . cord-010092-uftc8inx 2162 1 However however RB cord-010092-uftc8inx 2162 2 , , , cord-010092-uftc8inx 2162 3 it -PRON- PRP cord-010092-uftc8inx 2162 4 can can MD cord-010092-uftc8inx 2162 5 also also RB cord-010092-uftc8inx 2162 6 be be VB cord-010092-uftc8inx 2162 7 acquired acquire VBN cord-010092-uftc8inx 2162 8 by by IN cord-010092-uftc8inx 2162 9 blood blood NN cord-010092-uftc8inx 2162 10 transfusion transfusion NN cord-010092-uftc8inx 2162 11 and and CC cord-010092-uftc8inx 2162 12 organ organ NN cord-010092-uftc8inx 2162 13 transplantation transplantation NN cord-010092-uftc8inx 2162 14 . . . cord-010092-uftc8inx 2163 1 Toxoplasmosis toxoplasmosis NN cord-010092-uftc8inx 2163 2 can can MD cord-010092-uftc8inx 2163 3 be be VB cord-010092-uftc8inx 2163 4 a a DT cord-010092-uftc8inx 2163 5 severe severe JJ cord-010092-uftc8inx 2163 6 disease disease NN cord-010092-uftc8inx 2163 7 in in IN cord-010092-uftc8inx 2163 8 immunosuppressed immunosuppressed JJ cord-010092-uftc8inx 2163 9 people people NNS cord-010092-uftc8inx 2163 10 and and CC cord-010092-uftc8inx 2163 11 neonates neonate NNS cord-010092-uftc8inx 2163 12 whose whose WP$ cord-010092-uftc8inx 2163 13 mothers mother NNS cord-010092-uftc8inx 2163 14 have have VBP cord-010092-uftc8inx 2163 15 acquired acquire VBN cord-010092-uftc8inx 2163 16 primary primary JJ cord-010092-uftc8inx 2163 17 infection infection NN cord-010092-uftc8inx 2163 18 during during IN cord-010092-uftc8inx 2163 19 pregnancy pregnancy NN cord-010092-uftc8inx 2163 20 . . . cord-010092-uftc8inx 2164 1 Aims aim VBZ cord-010092-uftc8inx 2164 2 : : : cord-010092-uftc8inx 2165 1 There there EX cord-010092-uftc8inx 2165 2 is be VBZ cord-010092-uftc8inx 2165 3 no no DT cord-010092-uftc8inx 2165 4 information information NN cord-010092-uftc8inx 2165 5 about about IN cord-010092-uftc8inx 2165 6 the the DT cord-010092-uftc8inx 2165 7 specific specific JJ cord-010092-uftc8inx 2165 8 epidemiology epidemiology NN cord-010092-uftc8inx 2165 9 of of IN cord-010092-uftc8inx 2165 10 T. t. NN cord-010092-uftc8inx 2165 11 gondii gondii NN cord-010092-uftc8inx 2165 12 infection infection NN cord-010092-uftc8inx 2165 13 in in IN cord-010092-uftc8inx 2165 14 blood blood NN cord-010092-uftc8inx 2165 15 donors donor NNS cord-010092-uftc8inx 2165 16 in in IN cord-010092-uftc8inx 2165 17 Portugal Portugal NNP cord-010092-uftc8inx 2165 18 . . . cord-010092-uftc8inx 2166 1 Therefore therefore RB cord-010092-uftc8inx 2166 2 , , , cord-010092-uftc8inx 2166 3 we -PRON- PRP cord-010092-uftc8inx 2166 4 sought seek VBD cord-010092-uftc8inx 2166 5 to to TO cord-010092-uftc8inx 2166 6 determine determine VB cord-010092-uftc8inx 2166 7 the the DT cord-010092-uftc8inx 2166 8 seroprevalence seroprevalence NN cord-010092-uftc8inx 2166 9 of of IN cord-010092-uftc8inx 2166 10 T. t. NN cord-010092-uftc8inx 2166 11 gondii gondii NN cord-010092-uftc8inx 2166 12 and and CC cord-010092-uftc8inx 2166 13 associated associated JJ cord-010092-uftc8inx 2166 14 risk risk NN cord-010092-uftc8inx 2166 15 factors factor NNS cord-010092-uftc8inx 2166 16 in in IN cord-010092-uftc8inx 2166 17 the the DT cord-010092-uftc8inx 2166 18 population population NN cord-010092-uftc8inx 2166 19 of of IN cord-010092-uftc8inx 2166 20 blood blood NN cord-010092-uftc8inx 2166 21 donors donor NNS cord-010092-uftc8inx 2166 22 in in IN cord-010092-uftc8inx 2166 23 Portugal Portugal NNP cord-010092-uftc8inx 2166 24 . . . cord-010092-uftc8inx 2167 1 Methods method NNS cord-010092-uftc8inx 2167 2 : : : cord-010092-uftc8inx 2168 1 Between between IN cord-010092-uftc8inx 2168 2 September September NNP cord-010092-uftc8inx 2168 3 2015 2015 CD cord-010092-uftc8inx 2168 4 and and CC cord-010092-uftc8inx 2168 5 July July NNP cord-010092-uftc8inx 2168 6 2017 2017 CD cord-010092-uftc8inx 2168 7 , , , cord-010092-uftc8inx 2168 8 520 520 CD cord-010092-uftc8inx 2168 9 blood blood NN cord-010092-uftc8inx 2168 10 donors donor NNS cord-010092-uftc8inx 2168 11 who who WP cord-010092-uftc8inx 2168 12 attended attend VBD cord-010092-uftc8inx 2168 13 the the DT cord-010092-uftc8inx 2168 14 Portuguese Portuguese NNP cord-010092-uftc8inx 2168 15 Blood Blood NNP cord-010092-uftc8inx 2168 16 and and CC cord-010092-uftc8inx 2168 17 Transplantation Transplantation NNP cord-010092-uftc8inx 2168 18 Institute Institute NNP cord-010092-uftc8inx 2168 19 blood blood NN cord-010092-uftc8inx 2168 20 banks bank NNS cord-010092-uftc8inx 2168 21 located locate VBN cord-010092-uftc8inx 2168 22 in in IN cord-010092-uftc8inx 2168 23 Oporto Oporto NNP cord-010092-uftc8inx 2168 24 , , , cord-010092-uftc8inx 2168 25 Coimbra Coimbra NNP cord-010092-uftc8inx 2168 26 and and CC cord-010092-uftc8inx 2168 27 Lisbon Lisbon NNP cord-010092-uftc8inx 2168 28 , , , cord-010092-uftc8inx 2168 29 and and CC cord-010092-uftc8inx 2168 30 also also RB cord-010092-uftc8inx 2168 31 at at IN cord-010092-uftc8inx 2168 32 regional regional JJ cord-010092-uftc8inx 2168 33 blood blood NN cord-010092-uftc8inx 2168 34 collection collection NN cord-010092-uftc8inx 2168 35 meetings meeting NNS cord-010092-uftc8inx 2168 36 , , , cord-010092-uftc8inx 2168 37 were be VBD cord-010092-uftc8inx 2168 38 invited invite VBN cord-010092-uftc8inx 2168 39 to to TO cord-010092-uftc8inx 2168 40 participate participate VB cord-010092-uftc8inx 2168 41 in in IN cord-010092-uftc8inx 2168 42 the the DT cord-010092-uftc8inx 2168 43 study study NN cord-010092-uftc8inx 2168 44 . . . cord-010092-uftc8inx 2169 1 A a DT cord-010092-uftc8inx 2169 2 written write VBN cord-010092-uftc8inx 2169 3 informed informed JJ cord-010092-uftc8inx 2169 4 consent consent NN cord-010092-uftc8inx 2169 5 was be VBD cord-010092-uftc8inx 2169 6 obtained obtain VBN cord-010092-uftc8inx 2169 7 and and CC cord-010092-uftc8inx 2169 8 a a DT cord-010092-uftc8inx 2169 9 questionnaire questionnaire NN cord-010092-uftc8inx 2169 10 about about IN cord-010092-uftc8inx 2169 11 socio socio JJ cord-010092-uftc8inx 2169 12 - - HYPH cord-010092-uftc8inx 2169 13 demographic demographic JJ cord-010092-uftc8inx 2169 14 and and CC cord-010092-uftc8inx 2169 15 behavioural behavioural JJ cord-010092-uftc8inx 2169 16 variables variable NNS cord-010092-uftc8inx 2169 17 was be VBD cord-010092-uftc8inx 2169 18 answered answer VBN cord-010092-uftc8inx 2169 19 . . . cord-010092-uftc8inx 2170 1 Sera Sera NNP cord-010092-uftc8inx 2170 2 were be VBD cord-010092-uftc8inx 2170 3 assessed assess VBN cord-010092-uftc8inx 2170 4 for for IN cord-010092-uftc8inx 2170 5 IgG IgG NNP cord-010092-uftc8inx 2170 6 antibodies antibody NNS cord-010092-uftc8inx 2170 7 to to IN cord-010092-uftc8inx 2170 8 T. t. NN cord-010092-uftc8inx 2170 9 gondii gondii NN cord-010092-uftc8inx 2170 10 by by IN cord-010092-uftc8inx 2170 11 a a DT cord-010092-uftc8inx 2170 12 modified modify VBN cord-010092-uftc8inx 2170 13 agglutination agglutination NN cord-010092-uftc8inx 2170 14 test test NN cord-010092-uftc8inx 2170 15 ( ( -LRB- cord-010092-uftc8inx 2170 16 MAT MAT NNP cord-010092-uftc8inx 2170 17 ) ) -RRB- cord-010092-uftc8inx 2170 18 commercial commercial JJ cord-010092-uftc8inx 2170 19 kit kit NN cord-010092-uftc8inx 2170 20 ( ( -LRB- cord-010092-uftc8inx 2170 21 Toxo Toxo NNP cord-010092-uftc8inx 2170 22 - - HYPH cord-010092-uftc8inx 2170 23 Screen Screen NNP cord-010092-uftc8inx 2170 24 DA DA NNP cord-010092-uftc8inx 2170 25 â â , cord-010092-uftc8inx 2170 26 bioM biom JJ cord-010092-uftc8inx 2170 27 erieux erieux NNP cord-010092-uftc8inx 2170 28 , , , cord-010092-uftc8inx 2170 29 Lyon Lyon NNP cord-010092-uftc8inx 2170 30 , , , cord-010092-uftc8inx 2170 31 France France NNP cord-010092-uftc8inx 2170 32 ) ) -RRB- cord-010092-uftc8inx 2170 33 . . . cord-010092-uftc8inx 2171 1 Results result NNS cord-010092-uftc8inx 2171 2 : : : cord-010092-uftc8inx 2172 1 Of of IN cord-010092-uftc8inx 2172 2 the the DT cord-010092-uftc8inx 2172 3 520 520 CD cord-010092-uftc8inx 2172 4 blood blood NN cord-010092-uftc8inx 2172 5 donors donor NNS cord-010092-uftc8inx 2172 6 ( ( -LRB- cord-010092-uftc8inx 2172 7 mean mean VB cord-010092-uftc8inx 2172 8 age age NN cord-010092-uftc8inx 2172 9 38.55 38.55 CD cord-010092-uftc8inx 2172 10 AE AE NNP cord-010092-uftc8inx 2172 11 11.14 11.14 CD cord-010092-uftc8inx 2172 12 ; ; : cord-010092-uftc8inx 2172 13 range range VBP cord-010092-uftc8inx 2172 14 18 18 CD cord-010092-uftc8inx 2172 15 - - SYM cord-010092-uftc8inx 2172 16 65 65 CD cord-010092-uftc8inx 2172 17 years year NNS cord-010092-uftc8inx 2172 18 old old JJ cord-010092-uftc8inx 2172 19 ) ) -RRB- cord-010092-uftc8inx 2172 20 , , , cord-010092-uftc8inx 2172 21 38.1 38.1 CD cord-010092-uftc8inx 2172 22 % % NN cord-010092-uftc8inx 2172 23 were be VBD cord-010092-uftc8inx 2172 24 positive positive JJ cord-010092-uftc8inx 2172 25 for for IN cord-010092-uftc8inx 2172 26 antibodies antibody NNS cord-010092-uftc8inx 2172 27 to to IN cord-010092-uftc8inx 2172 28 T. t. NN cord-010092-uftc8inx 2172 29 gondii gondii NNP cord-010092-uftc8inx 2172 30 . . . cord-010092-uftc8inx 2173 1 When when WRB cord-010092-uftc8inx 2173 2 questioned question VBN cord-010092-uftc8inx 2173 3 about about IN cord-010092-uftc8inx 2173 4 toxoplasmosis toxoplasmosis NN cord-010092-uftc8inx 2173 5 , , , cord-010092-uftc8inx 2173 6 almost almost RB cord-010092-uftc8inx 2173 7 half half PDT cord-010092-uftc8inx 2173 8 the the DT cord-010092-uftc8inx 2173 9 blood blood NN cord-010092-uftc8inx 2173 10 donors donor NNS cord-010092-uftc8inx 2173 11 did do VBD cord-010092-uftc8inx 2173 12 not not RB cord-010092-uftc8inx 2173 13 have have VB cord-010092-uftc8inx 2173 14 any any DT cord-010092-uftc8inx 2173 15 knowledge knowledge NN cord-010092-uftc8inx 2173 16 about about IN cord-010092-uftc8inx 2173 17 the the DT cord-010092-uftc8inx 2173 18 disease disease NN cord-010092-uftc8inx 2173 19 . . . cord-010092-uftc8inx 2174 1 The the DT cord-010092-uftc8inx 2174 2 Centre Centre NNP cord-010092-uftc8inx 2174 3 of of IN cord-010092-uftc8inx 2174 4 Portugal Portugal NNP cord-010092-uftc8inx 2174 5 had have VBD cord-010092-uftc8inx 2174 6 the the DT cord-010092-uftc8inx 2174 7 highest high JJS cord-010092-uftc8inx 2174 8 seroprevalence seroprevalence NN cord-010092-uftc8inx 2174 9 ( ( -LRB- cord-010092-uftc8inx 2174 10 55.1 55.1 CD cord-010092-uftc8inx 2174 11 % % NN cord-010092-uftc8inx 2174 12 ) ) -RRB- cord-010092-uftc8inx 2174 13 followed follow VBN cord-010092-uftc8inx 2174 14 by by IN cord-010092-uftc8inx 2174 15 the the DT cord-010092-uftc8inx 2174 16 North North NNP cord-010092-uftc8inx 2174 17 ( ( -LRB- cord-010092-uftc8inx 2174 18 37.2 37.2 CD cord-010092-uftc8inx 2174 19 % % NN cord-010092-uftc8inx 2174 20 ) ) -RRB- cord-010092-uftc8inx 2174 21 and and CC cord-010092-uftc8inx 2174 22 the the DT cord-010092-uftc8inx 2174 23 South South NNP cord-010092-uftc8inx 2174 24 ( ( -LRB- cord-010092-uftc8inx 2174 25 25.3 25.3 CD cord-010092-uftc8inx 2174 26 % % NN cord-010092-uftc8inx 2174 27 ) ) -RRB- cord-010092-uftc8inx 2174 28 . . . cord-010092-uftc8inx 2175 1 Blood blood NN cord-010092-uftc8inx 2175 2 donors donor NNS cord-010092-uftc8inx 2175 3 living live VBG cord-010092-uftc8inx 2175 4 in in IN cord-010092-uftc8inx 2175 5 rural rural JJ cord-010092-uftc8inx 2175 6 areas area NNS cord-010092-uftc8inx 2175 7 had have VBD cord-010092-uftc8inx 2175 8 a a DT cord-010092-uftc8inx 2175 9 significantly significantly RB cord-010092-uftc8inx 2175 10 higher high JJR cord-010092-uftc8inx 2175 11 seroprevalence seroprevalence NN cord-010092-uftc8inx 2175 12 ( ( -LRB- cord-010092-uftc8inx 2175 13 P p NN cord-010092-uftc8inx 2175 14 = = SYM cord-010092-uftc8inx 2175 15 0.001 0.001 CD cord-010092-uftc8inx 2175 16 ) ) -RRB- cord-010092-uftc8inx 2175 17 than than IN cord-010092-uftc8inx 2175 18 those those DT cord-010092-uftc8inx 2175 19 living live VBG cord-010092-uftc8inx 2175 20 in in IN cord-010092-uftc8inx 2175 21 urban urban JJ cord-010092-uftc8inx 2175 22 areas area NNS cord-010092-uftc8inx 2175 23 . . . cord-010092-uftc8inx 2176 1 Seroprevalence Seroprevalence NNP cord-010092-uftc8inx 2176 2 increased increase VBD cord-010092-uftc8inx 2176 3 with with IN cord-010092-uftc8inx 2176 4 age age NN cord-010092-uftc8inx 2176 5 , , , cord-010092-uftc8inx 2176 6 with with IN cord-010092-uftc8inx 2176 7 the the DT cord-010092-uftc8inx 2176 8 highest high JJS cord-010092-uftc8inx 2176 9 seroprevalence seroprevalence NN cord-010092-uftc8inx 2176 10 ( ( -LRB- cord-010092-uftc8inx 2176 11 60.2 60.2 CD cord-010092-uftc8inx 2176 12 % % NN cord-010092-uftc8inx 2176 13 ) ) -RRB- cord-010092-uftc8inx 2176 14 found find VBN cord-010092-uftc8inx 2176 15 in in IN cord-010092-uftc8inx 2176 16 the the DT cord-010092-uftc8inx 2176 17 age age NN cord-010092-uftc8inx 2176 18 group group NN cord-010092-uftc8inx 2176 19 of of IN cord-010092-uftc8inx 2176 20 46 46 CD cord-010092-uftc8inx 2176 21 - - SYM cord-010092-uftc8inx 2176 22 55 55 CD cord-010092-uftc8inx 2176 23 years year NNS cord-010092-uftc8inx 2176 24 old old JJ cord-010092-uftc8inx 2176 25 ( ( -LRB- cord-010092-uftc8inx 2176 26 multiple multiple JJ cord-010092-uftc8inx 2176 27 logistic logistic JJ cord-010092-uftc8inx 2176 28 regression regression NN cord-010092-uftc8inx 2176 29 [ [ -LRB- cord-010092-uftc8inx 2176 30 MLR MLR NNP cord-010092-uftc8inx 2176 31 ] ] -RRB- cord-010092-uftc8inx 2176 32 : : : cord-010092-uftc8inx 2176 33 OR or CC cord-010092-uftc8inx 2176 34 = = SYM cord-010092-uftc8inx 2176 35 7.68 7.68 CD cord-010092-uftc8inx 2176 36 ; ; : cord-010092-uftc8inx 2176 37 CI CI NNP cord-010092-uftc8inx 2176 38 : : : cord-010092-uftc8inx 2176 39 4.08 4.08 CD cord-010092-uftc8inx 2176 40 - - SYM cord-010092-uftc8inx 2176 41 14.46 14.46 CD cord-010092-uftc8inx 2176 42 ; ; : cord-010092-uftc8inx 2176 43 P p NN cord-010092-uftc8inx 2176 44 < < XX cord-010092-uftc8inx 2176 45 0.001 0.001 CD cord-010092-uftc8inx 2176 46 ) ) -RRB- cord-010092-uftc8inx 2176 47 , , , cord-010092-uftc8inx 2176 48 and and CC cord-010092-uftc8inx 2176 49 decreased decrease VBD cord-010092-uftc8inx 2176 50 with with IN cord-010092-uftc8inx 2176 51 educational educational JJ cord-010092-uftc8inx 2176 52 level level NN cord-010092-uftc8inx 2176 53 ( ( -LRB- cord-010092-uftc8inx 2176 54 P p NN cord-010092-uftc8inx 2176 55 < < XX cord-010092-uftc8inx 2176 56 0.001 0.001 CD cord-010092-uftc8inx 2176 57 ) ) -RRB- cord-010092-uftc8inx 2176 58 . . . cord-010092-uftc8inx 2177 1 Engaging engage VBG cord-010092-uftc8inx 2177 2 in in IN cord-010092-uftc8inx 2177 3 soil soil NN cord-010092-uftc8inx 2177 4 - - HYPH cord-010092-uftc8inx 2177 5 related relate VBN cord-010092-uftc8inx 2177 6 activities activity NNS cord-010092-uftc8inx 2177 7 ( ( -LRB- cord-010092-uftc8inx 2177 8 gardening gardening NN cord-010092-uftc8inx 2177 9 or or CC cord-010092-uftc8inx 2177 10 agriculture agriculture NN cord-010092-uftc8inx 2177 11 ) ) -RRB- cord-010092-uftc8inx 2177 12 was be VBD cord-010092-uftc8inx 2177 13 significantly significantly RB cord-010092-uftc8inx 2177 14 related relate VBN cord-010092-uftc8inx 2177 15 to to IN cord-010092-uftc8inx 2177 16 T. t. NN cord-010092-uftc8inx 2177 17 gondii gondii NNP cord-010092-uftc8inx 2177 18 seropositivity seropositivity NN cord-010092-uftc8inx 2177 19 ( ( -LRB- cord-010092-uftc8inx 2177 20 P p NN cord-010092-uftc8inx 2177 21 = = SYM cord-010092-uftc8inx 2177 22 0.02 0.02 CD cord-010092-uftc8inx 2177 23 ) ) -RRB- cord-010092-uftc8inx 2177 24 . . . cord-010092-uftc8inx 2178 1 Regarding regard VBG cord-010092-uftc8inx 2178 2 water water NN cord-010092-uftc8inx 2178 3 consumption consumption NN cord-010092-uftc8inx 2178 4 , , , cord-010092-uftc8inx 2178 5 untreated untreated JJ cord-010092-uftc8inx 2178 6 sources source NNS cord-010092-uftc8inx 2178 7 ( ( -LRB- cord-010092-uftc8inx 2178 8 even even RB cord-010092-uftc8inx 2178 9 though though IN cord-010092-uftc8inx 2178 10 including include VBG cord-010092-uftc8inx 2178 11 mineral mineral NN cord-010092-uftc8inx 2178 12 and and CC cord-010092-uftc8inx 2178 13 tap tap NN cord-010092-uftc8inx 2178 14 water water NN cord-010092-uftc8inx 2178 15 ) ) -RRB- cord-010092-uftc8inx 2178 16 was be VBD cord-010092-uftc8inx 2178 17 confirmed confirm VBN cord-010092-uftc8inx 2178 18 as as IN cord-010092-uftc8inx 2178 19 a a DT cord-010092-uftc8inx 2178 20 risk risk NN cord-010092-uftc8inx 2178 21 factor factor NN cord-010092-uftc8inx 2178 22 ( ( -LRB- cord-010092-uftc8inx 2178 23 MLR MLR NNP cord-010092-uftc8inx 2178 24 : : : cord-010092-uftc8inx 2178 25 OR or CC cord-010092-uftc8inx 2178 26 = = SYM cord-010092-uftc8inx 2178 27 2.72 2.72 CD cord-010092-uftc8inx 2178 28 ; ; : cord-010092-uftc8inx 2178 29 CI ci NN cord-010092-uftc8inx 2178 30 : : : cord-010092-uftc8inx 2178 31 1.27 1.27 CD cord-010092-uftc8inx 2178 32 - - HYPH cord-010092-uftc8inx 2178 33 5.86 5.86 CD cord-010092-uftc8inx 2178 34 ; ; : cord-010092-uftc8inx 2178 35 P p NN cord-010092-uftc8inx 2178 36 = = SYM cord-010092-uftc8inx 2178 37 0.001 0.001 CD cord-010092-uftc8inx 2178 38 ) ) -RRB- cord-010092-uftc8inx 2178 39 . . . cord-010092-uftc8inx 2179 1 Other other JJ cord-010092-uftc8inx 2179 2 behavioural behavioural JJ cord-010092-uftc8inx 2179 3 and and CC cord-010092-uftc8inx 2179 4 eating eat VBG cord-010092-uftc8inx 2179 5 characteristics characteristic NNS cord-010092-uftc8inx 2179 6 , , , cord-010092-uftc8inx 2179 7 including include VBG cord-010092-uftc8inx 2179 8 cats cat NNS cord-010092-uftc8inx 2179 9 in in IN cord-010092-uftc8inx 2179 10 the the DT cord-010092-uftc8inx 2179 11 household household NN cord-010092-uftc8inx 2179 12 , , , cord-010092-uftc8inx 2179 13 eating eat VBG cord-010092-uftc8inx 2179 14 raw raw JJ cord-010092-uftc8inx 2179 15 or or CC cord-010092-uftc8inx 2179 16 undercooked undercooked JJ cord-010092-uftc8inx 2179 17 meat meat NN cord-010092-uftc8inx 2179 18 , , , cord-010092-uftc8inx 2179 19 processed process VBN cord-010092-uftc8inx 2179 20 pork pork NN cord-010092-uftc8inx 2179 21 products product NNS cord-010092-uftc8inx 2179 22 , , , cord-010092-uftc8inx 2179 23 or or CC cord-010092-uftc8inx 2179 24 not not RB cord-010092-uftc8inx 2179 25 washing wash VBG cord-010092-uftc8inx 2179 26 raw raw JJ cord-010092-uftc8inx 2179 27 fruit fruit NN cord-010092-uftc8inx 2179 28 and and CC cord-010092-uftc8inx 2179 29 vegetables vegetable NNS cord-010092-uftc8inx 2179 30 before before IN cord-010092-uftc8inx 2179 31 eating eat VBG cord-010092-uftc8inx 2179 32 , , , cord-010092-uftc8inx 2179 33 were be VBD cord-010092-uftc8inx 2179 34 not not RB cord-010092-uftc8inx 2179 35 associated associate VBN cord-010092-uftc8inx 2179 36 with with IN cord-010092-uftc8inx 2179 37 T. t. NN cord-010092-uftc8inx 2179 38 gondii gondii NN cord-010092-uftc8inx 2179 39 infection infection NN cord-010092-uftc8inx 2179 40 . . . cord-010092-uftc8inx 2180 1 Summary Summary NNP cord-010092-uftc8inx 2180 2 / / SYM cord-010092-uftc8inx 2180 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 2180 4 : : : cord-010092-uftc8inx 2181 1 The the DT cord-010092-uftc8inx 2181 2 risk risk NN cord-010092-uftc8inx 2181 3 of of IN cord-010092-uftc8inx 2181 4 T. t. NN cord-010092-uftc8inx 2181 5 gondii gondii NN cord-010092-uftc8inx 2181 6 transmission transmission NN cord-010092-uftc8inx 2181 7 through through IN cord-010092-uftc8inx 2181 8 blood blood NN cord-010092-uftc8inx 2181 9 transfusion transfusion NN cord-010092-uftc8inx 2181 10 is be VBZ cord-010092-uftc8inx 2181 11 low low JJ cord-010092-uftc8inx 2181 12 , , , cord-010092-uftc8inx 2181 13 and and CC cord-010092-uftc8inx 2181 14 serologic serologic JJ cord-010092-uftc8inx 2181 15 testing testing NN cord-010092-uftc8inx 2181 16 of of IN cord-010092-uftc8inx 2181 17 antibodies antibody NNS cord-010092-uftc8inx 2181 18 , , , cord-010092-uftc8inx 2181 19 with with IN cord-010092-uftc8inx 2181 20 exclusion exclusion NN cord-010092-uftc8inx 2181 21 of of IN cord-010092-uftc8inx 2181 22 blood blood NN cord-010092-uftc8inx 2181 23 donors donor NNS cord-010092-uftc8inx 2181 24 , , , cord-010092-uftc8inx 2181 25 appears appear VBZ cord-010092-uftc8inx 2181 26 not not RB cord-010092-uftc8inx 2181 27 to to TO cord-010092-uftc8inx 2181 28 be be VB cord-010092-uftc8inx 2181 29 feasible feasible JJ cord-010092-uftc8inx 2181 30 . . . cord-010092-uftc8inx 2182 1 Immunosuppressed immunosuppressed JJ cord-010092-uftc8inx 2182 2 individuals individual NNS cord-010092-uftc8inx 2182 3 , , , cord-010092-uftc8inx 2182 4 organ organ NN cord-010092-uftc8inx 2182 5 transplant transplant NN cord-010092-uftc8inx 2182 6 patients patient NNS cord-010092-uftc8inx 2182 7 and and CC cord-010092-uftc8inx 2182 8 pregnant pregnant JJ cord-010092-uftc8inx 2182 9 women woman NNS cord-010092-uftc8inx 2182 10 , , , cord-010092-uftc8inx 2182 11 should should MD cord-010092-uftc8inx 2182 12 receive receive VB cord-010092-uftc8inx 2182 13 T. T. NNP cord-010092-uftc8inx 2182 14 gondii gondii NNP cord-010092-uftc8inx 2182 15 antibody antibody NN cord-010092-uftc8inx 2182 16 - - HYPH cord-010092-uftc8inx 2182 17 negative negative JJ cord-010092-uftc8inx 2182 18 blood blood NN cord-010092-uftc8inx 2182 19 components component NNS cord-010092-uftc8inx 2182 20 for for IN cord-010092-uftc8inx 2182 21 transfusion transfusion NN cord-010092-uftc8inx 2182 22 . . . cord-010092-uftc8inx 2183 1 This this DT cord-010092-uftc8inx 2183 2 study study NN cord-010092-uftc8inx 2183 3 explored explore VBD cord-010092-uftc8inx 2183 4 the the DT cord-010092-uftc8inx 2183 5 epidemiology epidemiology NN cord-010092-uftc8inx 2183 6 of of IN cord-010092-uftc8inx 2183 7 T. t. NN cord-010092-uftc8inx 2183 8 gondii gondii NN cord-010092-uftc8inx 2183 9 in in IN cord-010092-uftc8inx 2183 10 Portugal Portugal NNP cord-010092-uftc8inx 2183 11 thus thus RB cord-010092-uftc8inx 2183 12 providing provide VBG cord-010092-uftc8inx 2183 13 useful useful JJ cord-010092-uftc8inx 2183 14 information information NN cord-010092-uftc8inx 2183 15 on on IN cord-010092-uftc8inx 2183 16 the the DT cord-010092-uftc8inx 2183 17 seroprevalence seroprevalence NN cord-010092-uftc8inx 2183 18 and and CC cord-010092-uftc8inx 2183 19 potential potential JJ cord-010092-uftc8inx 2183 20 risk risk NN cord-010092-uftc8inx 2183 21 factors factor NNS cord-010092-uftc8inx 2183 22 for for IN cord-010092-uftc8inx 2183 23 T. t. NN cord-010092-uftc8inx 2183 24 gondii gondii NN cord-010092-uftc8inx 2183 25 transmission transmission NN cord-010092-uftc8inx 2183 26 . . . cord-010092-uftc8inx 2184 1 Information information NN cord-010092-uftc8inx 2184 2 regarding regard VBG cord-010092-uftc8inx 2184 3 toxoplasmosis toxoplasmosi NNS cord-010092-uftc8inx 2184 4 and and CC cord-010092-uftc8inx 2184 5 its -PRON- PRP$ cord-010092-uftc8inx 2184 6 prevention prevention NN cord-010092-uftc8inx 2184 7 could could MD cord-010092-uftc8inx 2184 8 be be VB cord-010092-uftc8inx 2184 9 promoted promote VBN cord-010092-uftc8inx 2184 10 by by IN cord-010092-uftc8inx 2184 11 medical medical JJ cord-010092-uftc8inx 2184 12 and and CC cord-010092-uftc8inx 2184 13 public public JJ cord-010092-uftc8inx 2184 14 health health NN cord-010092-uftc8inx 2184 15 authorities authority NNS cord-010092-uftc8inx 2184 16 among among IN cord-010092-uftc8inx 2184 17 blood blood NN cord-010092-uftc8inx 2184 18 donors donor NNS cord-010092-uftc8inx 2184 19 , , , cord-010092-uftc8inx 2184 20 and and CC cord-010092-uftc8inx 2184 21 also also RB cord-010092-uftc8inx 2184 22 the the DT cord-010092-uftc8inx 2184 23 general general JJ cord-010092-uftc8inx 2184 24 population population NN cord-010092-uftc8inx 2184 25 , , , cord-010092-uftc8inx 2184 26 when when WRB cord-010092-uftc8inx 2184 27 addressing address VBG cord-010092-uftc8inx 2184 28 policies policy NNS cord-010092-uftc8inx 2184 29 , , , cord-010092-uftc8inx 2184 30 and and CC cord-010092-uftc8inx 2184 31 designing design VBG cord-010092-uftc8inx 2184 32 screening screening NN cord-010092-uftc8inx 2184 33 programs program NNS cord-010092-uftc8inx 2184 34 , , , cord-010092-uftc8inx 2184 35 for for IN cord-010092-uftc8inx 2184 36 monitoring monitor VBG cord-010092-uftc8inx 2184 37 and and CC cord-010092-uftc8inx 2184 38 controlling control VBG cord-010092-uftc8inx 2184 39 infection infection NN cord-010092-uftc8inx 2184 40 and and CC cord-010092-uftc8inx 2184 41 disease disease NN cord-010092-uftc8inx 2184 42 in in IN cord-010092-uftc8inx 2184 43 Portugal Portugal NNP cord-010092-uftc8inx 2184 44 . . . cord-010092-uftc8inx 2185 1 4A 4a LS cord-010092-uftc8inx 2185 2 - - : cord-010092-uftc8inx 2185 3 S18 S18 NNP cord-010092-uftc8inx 2185 4 - - HYPH cord-010092-uftc8inx 2185 5 05 05 CD cord-010092-uftc8inx 2185 6 WHO who WP cord-010092-uftc8inx 2185 7 IS be VBZ cord-010092-uftc8inx 2185 8 SYPHILIS syphili NNS cord-010092-uftc8inx 2185 9 TESTING testing NN cord-010092-uftc8inx 2185 10 EXCLUDING exclude VBN cord-010092-uftc8inx 2185 11 ? ? . cord-010092-uftc8inx 2186 1 C C NNP cord-010092-uftc8inx 2186 2 Reynolds Reynolds NNP cord-010092-uftc8inx 2186 3 1 1 CD cord-010092-uftc8inx 2186 4 , , , cord-010092-uftc8inx 2186 5 C C NNP cord-010092-uftc8inx 2186 6 Pearson Pearson NNP cord-010092-uftc8inx 2186 7 2 2 CD cord-010092-uftc8inx 2186 8 , , , cord-010092-uftc8inx 2186 9 K K NNP cord-010092-uftc8inx 2186 10 Davison Davison NNP cord-010092-uftc8inx 2186 11 2 2 CD cord-010092-uftc8inx 2186 12 and and CC cord-010092-uftc8inx 2186 13 S S NNP cord-010092-uftc8inx 2186 14 Brailsford Brailsford NNP cord-010092-uftc8inx 2186 15 1 1 CD cord-010092-uftc8inx 2186 16 1 1 CD cord-010092-uftc8inx 2186 17 NHSBT NHSBT NNP cord-010092-uftc8inx 2186 18 / / SYM cord-010092-uftc8inx 2186 19 PHE PHE NNP cord-010092-uftc8inx 2186 20 Epidemiology Epidemiology NNP cord-010092-uftc8inx 2186 21 Unit Unit NNP cord-010092-uftc8inx 2186 22 , , , cord-010092-uftc8inx 2186 23 NHS NHS NNP cord-010092-uftc8inx 2186 24 Blood Blood NNP cord-010092-uftc8inx 2186 25 and and CC cord-010092-uftc8inx 2186 26 Transplant Transplant NNP cord-010092-uftc8inx 2186 27 2 2 CD cord-010092-uftc8inx 2186 28 NHSBT NHSBT NNP cord-010092-uftc8inx 2186 29 / / SYM cord-010092-uftc8inx 2186 30 PHE PHE NNP cord-010092-uftc8inx 2186 31 Epidemiology Epidemiology NNP cord-010092-uftc8inx 2186 32 Unit Unit NNP cord-010092-uftc8inx 2186 33 , , , cord-010092-uftc8inx 2187 1 Public Public NNP cord-010092-uftc8inx 2187 2 Health Health NNP cord-010092-uftc8inx 2187 3 England England NNP cord-010092-uftc8inx 2187 4 , , , cord-010092-uftc8inx 2187 5 London London NNP cord-010092-uftc8inx 2187 6 , , , cord-010092-uftc8inx 2187 7 United United NNP cord-010092-uftc8inx 2187 8 Kingdom Kingdom NNP cord-010092-uftc8inx 2187 9 Background Background NNP cord-010092-uftc8inx 2187 10 : : : cord-010092-uftc8inx 2187 11 Screening screening NN cord-010092-uftc8inx 2187 12 for for IN cord-010092-uftc8inx 2187 13 treponemal treponemal JJ cord-010092-uftc8inx 2187 14 antibodies antibody NNS cord-010092-uftc8inx 2187 15 to to TO cord-010092-uftc8inx 2187 16 detect detect VB cord-010092-uftc8inx 2187 17 syphilis syphili NNS cord-010092-uftc8inx 2187 18 in in IN cord-010092-uftc8inx 2187 19 blood blood NN cord-010092-uftc8inx 2187 20 donors donor NNS cord-010092-uftc8inx 2187 21 has have VBZ cord-010092-uftc8inx 2187 22 been be VBN cord-010092-uftc8inx 2187 23 in in IN cord-010092-uftc8inx 2187 24 place place NN cord-010092-uftc8inx 2187 25 in in IN cord-010092-uftc8inx 2187 26 England England NNP cord-010092-uftc8inx 2187 27 since since IN cord-010092-uftc8inx 2187 28 the the DT cord-010092-uftc8inx 2187 29 1940s 1940 NNS cord-010092-uftc8inx 2187 30 . . . cord-010092-uftc8inx 2188 1 There there EX cord-010092-uftc8inx 2188 2 have have VBP cord-010092-uftc8inx 2188 3 been be VBN cord-010092-uftc8inx 2188 4 no no DT cord-010092-uftc8inx 2188 5 reported report VBN cord-010092-uftc8inx 2188 6 syphilis syphilis NN cord-010092-uftc8inx 2188 7 transfusion transfusion NN cord-010092-uftc8inx 2188 8 transmissions transmission NNS cord-010092-uftc8inx 2188 9 in in IN cord-010092-uftc8inx 2188 10 England England NNP cord-010092-uftc8inx 2188 11 since since IN cord-010092-uftc8inx 2188 12 records record NNS cord-010092-uftc8inx 2188 13 began begin VBD cord-010092-uftc8inx 2188 14 in in IN cord-010092-uftc8inx 2188 15 part part NN cord-010092-uftc8inx 2188 16 due due IN cord-010092-uftc8inx 2188 17 to to IN cord-010092-uftc8inx 2188 18 sensitivity sensitivity NN cord-010092-uftc8inx 2188 19 of of IN cord-010092-uftc8inx 2188 20 the the DT cord-010092-uftc8inx 2188 21 organism organism NN cord-010092-uftc8inx 2188 22 to to IN cord-010092-uftc8inx 2188 23 cold cold JJ cord-010092-uftc8inx 2188 24 storage storage NN cord-010092-uftc8inx 2188 25 . . . cord-010092-uftc8inx 2189 1 Since since IN cord-010092-uftc8inx 2189 2 we -PRON- PRP cord-010092-uftc8inx 2189 3 have have VBP cord-010092-uftc8inx 2189 4 specific specific JJ cord-010092-uftc8inx 2189 5 tests test NNS cord-010092-uftc8inx 2189 6 in in IN cord-010092-uftc8inx 2189 7 place place NN cord-010092-uftc8inx 2189 8 for for IN cord-010092-uftc8inx 2189 9 other other JJ cord-010092-uftc8inx 2189 10 sexually sexually RB cord-010092-uftc8inx 2189 11 transmitted transmit VBN cord-010092-uftc8inx 2189 12 infections infection NNS cord-010092-uftc8inx 2189 13 such such JJ cord-010092-uftc8inx 2189 14 as as IN cord-010092-uftc8inx 2189 15 HIV HIV NNP cord-010092-uftc8inx 2189 16 and and CC cord-010092-uftc8inx 2189 17 hepatitis hepatitis NNP cord-010092-uftc8inx 2189 18 B B NNP cord-010092-uftc8inx 2189 19 virus virus NN cord-010092-uftc8inx 2189 20 ( ( -LRB- cord-010092-uftc8inx 2189 21 HBV HBV NNP cord-010092-uftc8inx 2189 22 ) ) -RRB- cord-010092-uftc8inx 2189 23 , , , cord-010092-uftc8inx 2189 24 the the DT cord-010092-uftc8inx 2189 25 utility utility NN cord-010092-uftc8inx 2189 26 of of IN cord-010092-uftc8inx 2189 27 syphilis syphili NNS cord-010092-uftc8inx 2189 28 screening screening NN cord-010092-uftc8inx 2189 29 is be VBZ cord-010092-uftc8inx 2189 30 often often RB cord-010092-uftc8inx 2189 31 questioned question VBN cord-010092-uftc8inx 2189 32 . . . cord-010092-uftc8inx 2190 1 However however RB cord-010092-uftc8inx 2190 2 , , , cord-010092-uftc8inx 2190 3 it -PRON- PRP cord-010092-uftc8inx 2190 4 may may MD cord-010092-uftc8inx 2190 5 be be VB cord-010092-uftc8inx 2190 6 a a DT cord-010092-uftc8inx 2190 7 useful useful JJ cord-010092-uftc8inx 2190 8 proxy proxy NN cord-010092-uftc8inx 2190 9 for for IN cord-010092-uftc8inx 2190 10 higher high JJR cord-010092-uftc8inx 2190 11 risk risk NN cord-010092-uftc8inx 2190 12 behaviours behaviour NNS cord-010092-uftc8inx 2190 13 particularly particularly RB cord-010092-uftc8inx 2190 14 following follow VBG cord-010092-uftc8inx 2190 15 shortening shortening NN cord-010092-uftc8inx 2190 16 of of IN cord-010092-uftc8inx 2190 17 deferrals deferral NNS cord-010092-uftc8inx 2190 18 for for IN cord-010092-uftc8inx 2190 19 higher high JJR cord-010092-uftc8inx 2190 20 risk risk NN cord-010092-uftc8inx 2190 21 sexual sexual JJ cord-010092-uftc8inx 2190 22 behaviours behaviour NNS cord-010092-uftc8inx 2190 23 from from IN cord-010092-uftc8inx 2190 24 12 12 CD cord-010092-uftc8inx 2190 25 to to TO cord-010092-uftc8inx 2190 26 3 3 CD cord-010092-uftc8inx 2190 27 months month NNS cord-010092-uftc8inx 2190 28 in in IN cord-010092-uftc8inx 2190 29 November November NNP cord-010092-uftc8inx 2190 30 2017 2017 CD cord-010092-uftc8inx 2190 31 and and CC cord-010092-uftc8inx 2190 32 against against IN cord-010092-uftc8inx 2190 33 a a DT cord-010092-uftc8inx 2190 34 background background NN cord-010092-uftc8inx 2190 35 of of IN cord-010092-uftc8inx 2190 36 increasing increase VBG cord-010092-uftc8inx 2190 37 infectious infectious JJ cord-010092-uftc8inx 2190 38 syphilis syphili NNS cord-010092-uftc8inx 2190 39 in in IN cord-010092-uftc8inx 2190 40 the the DT cord-010092-uftc8inx 2190 41 general general JJ cord-010092-uftc8inx 2190 42 population population NN cord-010092-uftc8inx 2190 43 . . . cord-010092-uftc8inx 2191 1 Aims aim VBZ cord-010092-uftc8inx 2191 2 : : : cord-010092-uftc8inx 2192 1 Here here RB cord-010092-uftc8inx 2192 2 we -PRON- PRP cord-010092-uftc8inx 2192 3 describe describe VBP cord-010092-uftc8inx 2192 4 the the DT cord-010092-uftc8inx 2192 5 epidemiology epidemiology NN cord-010092-uftc8inx 2192 6 of of IN cord-010092-uftc8inx 2192 7 recently recently RB cord-010092-uftc8inx 2192 8 - - HYPH cord-010092-uftc8inx 2192 9 acquired acquire VBN cord-010092-uftc8inx 2192 10 syphilis syphili NNS cord-010092-uftc8inx 2192 11 in in IN cord-010092-uftc8inx 2192 12 blood blood NN cord-010092-uftc8inx 2192 13 donors donor NNS cord-010092-uftc8inx 2192 14 in in IN cord-010092-uftc8inx 2192 15 England England NNP cord-010092-uftc8inx 2192 16 compared compare VBN cord-010092-uftc8inx 2192 17 with with IN cord-010092-uftc8inx 2192 18 HIV HIV NNP cord-010092-uftc8inx 2192 19 and and CC cord-010092-uftc8inx 2192 20 acute acute JJ cord-010092-uftc8inx 2192 21 HBV HBV NNP cord-010092-uftc8inx 2192 22 infection infection NN cord-010092-uftc8inx 2192 23 between between IN cord-010092-uftc8inx 2192 24 2009 2009 CD cord-010092-uftc8inx 2192 25 and and CC cord-010092-uftc8inx 2192 26 2018 2018 CD cord-010092-uftc8inx 2192 27 . . . cord-010092-uftc8inx 2193 1 Methods method NNS cord-010092-uftc8inx 2193 2 : : : cord-010092-uftc8inx 2193 3 Monthly monthly JJ cord-010092-uftc8inx 2193 4 donation donation NN cord-010092-uftc8inx 2193 5 testing testing NN cord-010092-uftc8inx 2193 6 results result NNS cord-010092-uftc8inx 2193 7 are be VBP cord-010092-uftc8inx 2193 8 collected collect VBN cord-010092-uftc8inx 2193 9 from from IN cord-010092-uftc8inx 2193 10 the the DT cord-010092-uftc8inx 2193 11 NHS NHS NNP cord-010092-uftc8inx 2193 12 Blood Blood NNP cord-010092-uftc8inx 2193 13 and and CC cord-010092-uftc8inx 2193 14 Transplant Transplant NNP cord-010092-uftc8inx 2193 15 ( ( -LRB- cord-010092-uftc8inx 2193 16 NHSBT NHSBT NNP cord-010092-uftc8inx 2193 17 ) ) -RRB- cord-010092-uftc8inx 2193 18 screening screening NN cord-010092-uftc8inx 2193 19 centres centre NNS cord-010092-uftc8inx 2193 20 and and CC cord-010092-uftc8inx 2193 21 reference reference NN cord-010092-uftc8inx 2193 22 laboratory laboratory NN cord-010092-uftc8inx 2193 23 . . . cord-010092-uftc8inx 2194 1 The the DT cord-010092-uftc8inx 2194 2 demographics demographic NNS cord-010092-uftc8inx 2194 3 , , , cord-010092-uftc8inx 2194 4 possible possible JJ cord-010092-uftc8inx 2194 5 sources source NNS cord-010092-uftc8inx 2194 6 of of IN cord-010092-uftc8inx 2194 7 infection infection NN cord-010092-uftc8inx 2194 8 , , , cord-010092-uftc8inx 2194 9 and and CC cord-010092-uftc8inx 2194 10 compliance compliance NN cord-010092-uftc8inx 2194 11 to to IN cord-010092-uftc8inx 2194 12 donor donor NN cord-010092-uftc8inx 2194 13 selection selection NN cord-010092-uftc8inx 2194 14 in in IN cord-010092-uftc8inx 2194 15 confirmed confirm VBD cord-010092-uftc8inx 2194 16 positive positive JJ cord-010092-uftc8inx 2194 17 donors donor NNS cord-010092-uftc8inx 2194 18 are be VBP cord-010092-uftc8inx 2194 19 collected collect VBN cord-010092-uftc8inx 2194 20 by by IN cord-010092-uftc8inx 2194 21 proforma proforma NNS cord-010092-uftc8inx 2194 22 at at IN cord-010092-uftc8inx 2194 23 post post JJ cord-010092-uftc8inx 2194 24 - - JJ cord-010092-uftc8inx 2194 25 test test JJ cord-010092-uftc8inx 2194 26 discussion discussion NN cord-010092-uftc8inx 2194 27 with with IN cord-010092-uftc8inx 2194 28 the the DT cord-010092-uftc8inx 2194 29 NHSBT NHSBT NNP cord-010092-uftc8inx 2194 30 clinical clinical JJ cord-010092-uftc8inx 2194 31 team team NN cord-010092-uftc8inx 2194 32 . . . cord-010092-uftc8inx 2195 1 Recent recent JJ cord-010092-uftc8inx 2195 2 syphilis syphili NNS cord-010092-uftc8inx 2195 3 is be VBZ cord-010092-uftc8inx 2195 4 classified classify VBN cord-010092-uftc8inx 2195 5 as as IN cord-010092-uftc8inx 2195 6 IgM IgM NNP cord-010092-uftc8inx 2195 7 positive positive JJ cord-010092-uftc8inx 2195 8 and/or and/or CC cord-010092-uftc8inx 2195 9 recent recent JJ cord-010092-uftc8inx 2195 10 history history NN cord-010092-uftc8inx 2195 11 including include VBG cord-010092-uftc8inx 2195 12 a a DT cord-010092-uftc8inx 2195 13 negative negative JJ cord-010092-uftc8inx 2195 14 donation donation NN cord-010092-uftc8inx 2195 15 within within IN cord-010092-uftc8inx 2195 16 12 12 CD cord-010092-uftc8inx 2195 17 months month NNS cord-010092-uftc8inx 2195 18 for for IN cord-010092-uftc8inx 2195 19 regular regular JJ cord-010092-uftc8inx 2195 20 donors donor NNS cord-010092-uftc8inx 2195 21 . . . cord-010092-uftc8inx 2196 1 Results result NNS cord-010092-uftc8inx 2196 2 : : : cord-010092-uftc8inx 2197 1 Between between IN cord-010092-uftc8inx 2197 2 2009 2009 CD cord-010092-uftc8inx 2197 3 and and CC cord-010092-uftc8inx 2197 4 2018 2018 CD cord-010092-uftc8inx 2197 5 there there EX cord-010092-uftc8inx 2197 6 were be VBD cord-010092-uftc8inx 2197 7 153 153 CD cord-010092-uftc8inx 2197 8 recent recent JJ cord-010092-uftc8inx 2197 9 syphilis syphili NNS cord-010092-uftc8inx 2197 10 cases case NNS cord-010092-uftc8inx 2197 11 , , , cord-010092-uftc8inx 2197 12 121 121 CD cord-010092-uftc8inx 2197 13 HIV HIV NNP cord-010092-uftc8inx 2197 14 and and CC cord-010092-uftc8inx 2197 15 32 32 CD cord-010092-uftc8inx 2197 16 acute acute JJ cord-010092-uftc8inx 2197 17 HBV HBV NNP cord-010092-uftc8inx 2197 18 infections infection NNS cord-010092-uftc8inx 2197 19 identified identify VBN cord-010092-uftc8inx 2197 20 by by IN cord-010092-uftc8inx 2197 21 donation donation NN cord-010092-uftc8inx 2197 22 screening screening NN cord-010092-uftc8inx 2197 23 . . . cord-010092-uftc8inx 2198 1 Recent recent JJ cord-010092-uftc8inx 2198 2 syphilis syphili NNS cord-010092-uftc8inx 2198 3 rates rate NNS cord-010092-uftc8inx 2198 4 per per IN cord-010092-uftc8inx 2198 5 100,000 100,000 CD cord-010092-uftc8inx 2198 6 donations donation NNS cord-010092-uftc8inx 2198 7 increased increase VBD cord-010092-uftc8inx 2198 8 from from IN cord-010092-uftc8inx 2198 9 0.66 0.66 CD cord-010092-uftc8inx 2198 10 to to TO cord-010092-uftc8inx 2198 11 1.64 1.64 CD cord-010092-uftc8inx 2198 12 whereas whereas IN cord-010092-uftc8inx 2198 13 HIV HIV NNP cord-010092-uftc8inx 2198 14 decreased decrease VBD cord-010092-uftc8inx 2198 15 from from IN cord-010092-uftc8inx 2198 16 1.04 1.04 CD cord-010092-uftc8inx 2198 17 to to IN cord-010092-uftc8inx 2198 18 0.19 0.19 CD cord-010092-uftc8inx 2198 19 with with IN cord-010092-uftc8inx 2198 20 less less JJR cord-010092-uftc8inx 2198 21 than than IN cord-010092-uftc8inx 2198 22 5 5 CD cord-010092-uftc8inx 2198 23 positive positive JJ cord-010092-uftc8inx 2198 24 donations donation NNS cord-010092-uftc8inx 2198 25 in in IN cord-010092-uftc8inx 2198 26 2018 2018 CD cord-010092-uftc8inx 2198 27 . . . cord-010092-uftc8inx 2199 1 Acute acute JJ cord-010092-uftc8inx 2199 2 HBV HBV NNP cord-010092-uftc8inx 2199 3 rates rate NNS cord-010092-uftc8inx 2199 4 rose rise VBD cord-010092-uftc8inx 2199 5 slightly slightly RB cord-010092-uftc8inx 2199 6 from from IN cord-010092-uftc8inx 2199 7 0.28 0.28 CD cord-010092-uftc8inx 2199 8 to to IN cord-010092-uftc8inx 2199 9 0.38 0.38 CD cord-010092-uftc8inx 2199 10 in in IN cord-010092-uftc8inx 2199 11 2018 2018 CD cord-010092-uftc8inx 2199 12 . . . cord-010092-uftc8inx 2200 1 Males male NNS cord-010092-uftc8inx 2200 2 outweighed outweigh VBD cord-010092-uftc8inx 2200 3 females female NNS cord-010092-uftc8inx 2200 4 accounting account VBG cord-010092-uftc8inx 2200 5 for for IN cord-010092-uftc8inx 2200 6 71.9 71.9 CD cord-010092-uftc8inx 2200 7 % % NN cord-010092-uftc8inx 2200 8 , , , cord-010092-uftc8inx 2200 9 63.6 63.6 CD cord-010092-uftc8inx 2200 10 % % NN cord-010092-uftc8inx 2200 11 and and CC cord-010092-uftc8inx 2200 12 59.4 59.4 CD cord-010092-uftc8inx 2200 13 % % NN cord-010092-uftc8inx 2200 14 of of IN cord-010092-uftc8inx 2200 15 cases case NNS cord-010092-uftc8inx 2200 16 of of IN cord-010092-uftc8inx 2200 17 recent recent JJ cord-010092-uftc8inx 2200 18 syphilis syphili NNS cord-010092-uftc8inx 2200 19 , , , cord-010092-uftc8inx 2200 20 HIV HIV NNP cord-010092-uftc8inx 2200 21 and and CC cord-010092-uftc8inx 2200 22 acute acute JJ cord-010092-uftc8inx 2200 23 HBV HBV NNP cord-010092-uftc8inx 2200 24 respectively respectively RB cord-010092-uftc8inx 2200 25 . . . cord-010092-uftc8inx 2201 1 Nearly nearly RB cord-010092-uftc8inx 2201 2 a a DT cord-010092-uftc8inx 2201 3 quarter quarter NN cord-010092-uftc8inx 2201 4 of of IN cord-010092-uftc8inx 2201 5 cases case NNS cord-010092-uftc8inx 2201 6 of of IN cord-010092-uftc8inx 2201 7 recent recent JJ cord-010092-uftc8inx 2201 8 syphilis syphili NNS cord-010092-uftc8inx 2201 9 and and CC cord-010092-uftc8inx 2201 10 HIV HIV NNP cord-010092-uftc8inx 2201 11 were be VBD cord-010092-uftc8inx 2201 12 seen see VBN cord-010092-uftc8inx 2201 13 in in IN cord-010092-uftc8inx 2201 14 donors donor NNS cord-010092-uftc8inx 2201 15 below below IN cord-010092-uftc8inx 2201 16 25 25 CD cord-010092-uftc8inx 2201 17 years year NNS cord-010092-uftc8inx 2201 18 old old JJ cord-010092-uftc8inx 2201 19 . . . cord-010092-uftc8inx 2202 1 Of of IN cord-010092-uftc8inx 2202 2 the the DT cord-010092-uftc8inx 2202 3 male male JJ cord-010092-uftc8inx 2202 4 donors donor NNS cord-010092-uftc8inx 2202 5 with with IN cord-010092-uftc8inx 2202 6 recent recent JJ cord-010092-uftc8inx 2202 7 syphilis syphili NNS cord-010092-uftc8inx 2202 8 , , , cord-010092-uftc8inx 2202 9 58.2 58.2 CD cord-010092-uftc8inx 2202 10 % % NN cord-010092-uftc8inx 2202 11 reported report VBD cord-010092-uftc8inx 2202 12 sex sex NN cord-010092-uftc8inx 2202 13 between between IN cord-010092-uftc8inx 2202 14 men man NNS cord-010092-uftc8inx 2202 15 and and CC cord-010092-uftc8inx 2202 16 women woman NNS cord-010092-uftc8inx 2202 17 ( ( -LRB- cord-010092-uftc8inx 2202 18 SBMW SBMW NNP cord-010092-uftc8inx 2202 19 ) ) -RRB- cord-010092-uftc8inx 2202 20 , , , cord-010092-uftc8inx 2202 21 19.1 19.1 CD cord-010092-uftc8inx 2202 22 % % NN cord-010092-uftc8inx 2202 23 sex sex NN cord-010092-uftc8inx 2202 24 between between IN cord-010092-uftc8inx 2202 25 men man NNS cord-010092-uftc8inx 2202 26 ( ( -LRB- cord-010092-uftc8inx 2202 27 SBM SBM NNP cord-010092-uftc8inx 2202 28 ) ) -RRB- cord-010092-uftc8inx 2202 29 and and CC cord-010092-uftc8inx 2202 30 22.7 22.7 CD cord-010092-uftc8inx 2202 31 % % NN cord-010092-uftc8inx 2202 32 did do VBD cord-010092-uftc8inx 2202 33 not not RB cord-010092-uftc8inx 2202 34 report report VB cord-010092-uftc8inx 2202 35 a a DT cord-010092-uftc8inx 2202 36 risk risk NN cord-010092-uftc8inx 2202 37 . . . cord-010092-uftc8inx 2203 1 This this DT cord-010092-uftc8inx 2203 2 contrasted contrast VBD cord-010092-uftc8inx 2203 3 with with IN cord-010092-uftc8inx 2203 4 HIV HIV NNP cord-010092-uftc8inx 2203 5 where where WRB cord-010092-uftc8inx 2203 6 45.5 45.5 CD cord-010092-uftc8inx 2203 7 % % NN cord-010092-uftc8inx 2203 8 of of IN cord-010092-uftc8inx 2203 9 male male JJ cord-010092-uftc8inx 2203 10 donors donor NNS cord-010092-uftc8inx 2203 11 reported report VBD cord-010092-uftc8inx 2203 12 SBM SBM NNP cord-010092-uftc8inx 2203 13 , , , cord-010092-uftc8inx 2203 14 just just RB cord-010092-uftc8inx 2203 15 2.6 2.6 CD cord-010092-uftc8inx 2203 16 % % NN cord-010092-uftc8inx 2203 17 not not RB cord-010092-uftc8inx 2203 18 reporting report VBG cord-010092-uftc8inx 2203 19 a a DT cord-010092-uftc8inx 2203 20 risk risk NN cord-010092-uftc8inx 2203 21 . . . cord-010092-uftc8inx 2204 1 Overall overall RB cord-010092-uftc8inx 2204 2 19 19 CD cord-010092-uftc8inx 2204 3 , , , cord-010092-uftc8inx 2204 4 32 32 CD cord-010092-uftc8inx 2204 5 and and CC cord-010092-uftc8inx 2204 6 3 3 CD cord-010092-uftc8inx 2204 7 males male NNS cord-010092-uftc8inx 2204 8 with with IN cord-010092-uftc8inx 2204 9 recent recent JJ cord-010092-uftc8inx 2204 10 syphilis syphili NNS cord-010092-uftc8inx 2204 11 , , , cord-010092-uftc8inx 2204 12 HIV HIV NNP cord-010092-uftc8inx 2204 13 or or CC cord-010092-uftc8inx 2204 14 acute acute JJ cord-010092-uftc8inx 2204 15 HBV HBV NNP cord-010092-uftc8inx 2204 16 respectively respectively RB cord-010092-uftc8inx 2204 17 were be VBD cord-010092-uftc8inx 2204 18 non non JJ cord-010092-uftc8inx 2204 19 - - JJ cord-010092-uftc8inx 2204 20 compliant compliant JJ cord-010092-uftc8inx 2204 21 to to IN cord-010092-uftc8inx 2204 22 the the DT cord-010092-uftc8inx 2204 23 SBM SBM NNP cord-010092-uftc8inx 2204 24 deferral deferral NN cord-010092-uftc8inx 2204 25 in in IN cord-010092-uftc8inx 2204 26 place place NN cord-010092-uftc8inx 2204 27 at at IN cord-010092-uftc8inx 2204 28 the the DT cord-010092-uftc8inx 2204 29 time time NN cord-010092-uftc8inx 2204 30 of of IN cord-010092-uftc8inx 2204 31 donation donation NN cord-010092-uftc8inx 2204 32 . . . cord-010092-uftc8inx 2205 1 In in IN cord-010092-uftc8inx 2205 2 2018 2018 CD cord-010092-uftc8inx 2205 3 , , , cord-010092-uftc8inx 2205 4 26 26 CD cord-010092-uftc8inx 2205 5 donors donor NNS cord-010092-uftc8inx 2205 6 with with IN cord-010092-uftc8inx 2205 7 recent recent JJ cord-010092-uftc8inx 2205 8 syphilis syphili NNS cord-010092-uftc8inx 2205 9 aged age VBN cord-010092-uftc8inx 2205 10 23 23 CD cord-010092-uftc8inx 2205 11 - - SYM cord-010092-uftc8inx 2205 12 65 65 CD cord-010092-uftc8inx 2205 13 years year NNS cord-010092-uftc8inx 2205 14 ( ( -LRB- cord-010092-uftc8inx 2205 15 median median JJ cord-010092-uftc8inx 2205 16 36 36 CD cord-010092-uftc8inx 2205 17 years year NNS cord-010092-uftc8inx 2205 18 ) ) -RRB- cord-010092-uftc8inx 2205 19 were be VBD cord-010092-uftc8inx 2205 20 excluded exclude VBN cord-010092-uftc8inx 2205 21 from from IN cord-010092-uftc8inx 2205 22 the the DT cord-010092-uftc8inx 2205 23 donor donor NN cord-010092-uftc8inx 2205 24 pool pool NN cord-010092-uftc8inx 2205 25 , , , cord-010092-uftc8inx 2205 26 including include VBG cord-010092-uftc8inx 2205 27 3 3 CD cord-010092-uftc8inx 2205 28 non non JJ cord-010092-uftc8inx 2205 29 - - JJ cord-010092-uftc8inx 2205 30 compliant compliant JJ cord-010092-uftc8inx 2205 31 to to IN cord-010092-uftc8inx 2205 32 the the DT cord-010092-uftc8inx 2205 33 SBM SBM NNP cord-010092-uftc8inx 2205 34 deferral deferral NN cord-010092-uftc8inx 2205 35 . . . cord-010092-uftc8inx 2206 1 There there EX cord-010092-uftc8inx 2206 2 were be VBD cord-010092-uftc8inx 2206 3 fewer few JJR cord-010092-uftc8inx 2206 4 than than IN cord-010092-uftc8inx 2206 5 5 5 CD cord-010092-uftc8inx 2206 6 HIV HIV NNP cord-010092-uftc8inx 2206 7 cases case NNS cord-010092-uftc8inx 2206 8 identified identify VBN cord-010092-uftc8inx 2206 9 in in IN cord-010092-uftc8inx 2206 10 2018 2018 CD cord-010092-uftc8inx 2206 11 , , , cord-010092-uftc8inx 2206 12 all all RB cord-010092-uftc8inx 2206 13 over over IN cord-010092-uftc8inx 2206 14 40 40 CD cord-010092-uftc8inx 2206 15 years year NNS cord-010092-uftc8inx 2206 16 old old JJ cord-010092-uftc8inx 2206 17 , , , cord-010092-uftc8inx 2206 18 all all DT cord-010092-uftc8inx 2206 19 compliant compliant JJ cord-010092-uftc8inx 2206 20 , , , cord-010092-uftc8inx 2206 21 reporting report VBG cord-010092-uftc8inx 2206 22 SBMW SBMW NNP cord-010092-uftc8inx 2206 23 . . . cord-010092-uftc8inx 2207 1 Of of IN cord-010092-uftc8inx 2207 2 the the DT cord-010092-uftc8inx 2207 3 6 6 CD cord-010092-uftc8inx 2207 4 HBV HBV NNP cord-010092-uftc8inx 2207 5 acute acute JJ cord-010092-uftc8inx 2207 6 cases case NNS cord-010092-uftc8inx 2207 7 in in IN cord-010092-uftc8inx 2207 8 2018 2018 CD cord-010092-uftc8inx 2207 9 , , , cord-010092-uftc8inx 2207 10 5 5 CD cord-010092-uftc8inx 2207 11 were be VBD cord-010092-uftc8inx 2207 12 male male JJ cord-010092-uftc8inx 2207 13 , , , cord-010092-uftc8inx 2207 14 all all DT cord-010092-uftc8inx 2207 15 but but IN cord-010092-uftc8inx 2207 16 one one CD cord-010092-uftc8inx 2207 17 in in IN cord-010092-uftc8inx 2207 18 the the DT cord-010092-uftc8inx 2207 19 45 45 CD cord-010092-uftc8inx 2207 20 and and CC cord-010092-uftc8inx 2207 21 over over IN cord-010092-uftc8inx 2207 22 age age NN cord-010092-uftc8inx 2207 23 - - HYPH cord-010092-uftc8inx 2207 24 group group NN cord-010092-uftc8inx 2207 25 . . . cord-010092-uftc8inx 2208 1 Summary Summary NNP cord-010092-uftc8inx 2208 2 / / SYM cord-010092-uftc8inx 2208 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 2208 4 : : : cord-010092-uftc8inx 2209 1 Over over IN cord-010092-uftc8inx 2209 2 the the DT cord-010092-uftc8inx 2209 3 10 10 CD cord-010092-uftc8inx 2209 4 year year NN cord-010092-uftc8inx 2209 5 period period NN cord-010092-uftc8inx 2209 6 demographics demographic NNS cord-010092-uftc8inx 2209 7 of of IN cord-010092-uftc8inx 2209 8 recent recent JJ cord-010092-uftc8inx 2209 9 syphilis syphili NNS cord-010092-uftc8inx 2209 10 cases case NNS cord-010092-uftc8inx 2209 11 appeared appear VBD cord-010092-uftc8inx 2209 12 similar similar JJ cord-010092-uftc8inx 2209 13 to to IN cord-010092-uftc8inx 2209 14 HIV HIV NNP cord-010092-uftc8inx 2209 15 with with IN cord-010092-uftc8inx 2209 16 highest high JJS cord-010092-uftc8inx 2209 17 rates rate NNS cord-010092-uftc8inx 2209 18 in in IN cord-010092-uftc8inx 2209 19 young young JJ cord-010092-uftc8inx 2209 20 males male NNS cord-010092-uftc8inx 2209 21 , , , cord-010092-uftc8inx 2209 22 albeit albeit IN cord-010092-uftc8inx 2209 23 lower low JJR cord-010092-uftc8inx 2209 24 proportions proportion NNS cord-010092-uftc8inx 2209 25 reporting report VBG cord-010092-uftc8inx 2209 26 SBM SBM NNP cord-010092-uftc8inx 2209 27 . . . cord-010092-uftc8inx 2210 1 Following follow VBG cord-010092-uftc8inx 2210 2 the the DT cord-010092-uftc8inx 2210 3 switch switch NN cord-010092-uftc8inx 2210 4 to to IN cord-010092-uftc8inx 2210 5 a a DT cord-010092-uftc8inx 2210 6 3 3 CD cord-010092-uftc8inx 2210 7 month month NN cord-010092-uftc8inx 2210 8 deferral deferral NN cord-010092-uftc8inx 2210 9 , , , cord-010092-uftc8inx 2210 10 HIV HIV NNP cord-010092-uftc8inx 2210 11 case case NN cord-010092-uftc8inx 2210 12 detection detection NN cord-010092-uftc8inx 2210 13 continued continue VBD cord-010092-uftc8inx 2210 14 at at IN cord-010092-uftc8inx 2210 15 low low JJ cord-010092-uftc8inx 2210 16 level level NN cord-010092-uftc8inx 2210 17 , , , cord-010092-uftc8inx 2210 18 while while IN cord-010092-uftc8inx 2210 19 syphilis syphili NNS cord-010092-uftc8inx 2210 20 screening screening NN cord-010092-uftc8inx 2210 21 continued continue VBD cord-010092-uftc8inx 2210 22 to to TO cord-010092-uftc8inx 2210 23 exclude exclude VB cord-010092-uftc8inx 2210 24 higher high JJR cord-010092-uftc8inx 2210 25 numbers number NNS cord-010092-uftc8inx 2210 26 spanning span VBG cord-010092-uftc8inx 2210 27 all all DT cord-010092-uftc8inx 2210 28 age age NN cord-010092-uftc8inx 2210 29 - - HYPH cord-010092-uftc8inx 2210 30 groups group NNS cord-010092-uftc8inx 2210 31 , , , cord-010092-uftc8inx 2210 32 potentially potentially RB cord-010092-uftc8inx 2210 33 at at IN cord-010092-uftc8inx 2210 34 risk risk NN cord-010092-uftc8inx 2210 35 of of IN cord-010092-uftc8inx 2210 36 other other JJ cord-010092-uftc8inx 2210 37 sexually sexually RB cord-010092-uftc8inx 2210 38 transmitted transmit VBN cord-010092-uftc8inx 2210 39 infections infection NNS cord-010092-uftc8inx 2210 40 , , , cord-010092-uftc8inx 2210 41 including include VBG cord-010092-uftc8inx 2210 42 non non JJ cord-010092-uftc8inx 2210 43 - - JJ cord-010092-uftc8inx 2210 44 compliant compliant JJ cord-010092-uftc8inx 2210 45 donors donor NNS cord-010092-uftc8inx 2210 46 . . . cord-010092-uftc8inx 2211 1 Background background NN cord-010092-uftc8inx 2211 2 : : : cord-010092-uftc8inx 2212 1 Globally globally RB cord-010092-uftc8inx 2212 2 , , , cord-010092-uftc8inx 2212 3 an an DT cord-010092-uftc8inx 2212 4 estimated estimate VBN cord-010092-uftc8inx 2212 5 113 113 CD cord-010092-uftc8inx 2212 6 million million CD cord-010092-uftc8inx 2212 7 blood blood NN cord-010092-uftc8inx 2212 8 donations donation NNS cord-010092-uftc8inx 2212 9 are be VBP cord-010092-uftc8inx 2212 10 given give VBN cord-010092-uftc8inx 2212 11 annually annually RB cord-010092-uftc8inx 2212 12 . . . cord-010092-uftc8inx 2213 1 In in IN cord-010092-uftc8inx 2213 2 the the DT cord-010092-uftc8inx 2213 3 blood blood NN cord-010092-uftc8inx 2213 4 service service NN cord-010092-uftc8inx 2213 5 we -PRON- PRP cord-010092-uftc8inx 2213 6 are be VBP cord-010092-uftc8inx 2213 7 obliged oblige VBN cord-010092-uftc8inx 2213 8 to to TO cord-010092-uftc8inx 2213 9 monitor monitor VB cord-010092-uftc8inx 2213 10 donor donor NN cord-010092-uftc8inx 2213 11 health health NN cord-010092-uftc8inx 2213 12 and and CC cord-010092-uftc8inx 2213 13 ensure ensure VB cord-010092-uftc8inx 2213 14 that that DT cord-010092-uftc8inx 2213 15 blood blood NN cord-010092-uftc8inx 2213 16 donation donation NN cord-010092-uftc8inx 2213 17 is be VBZ cord-010092-uftc8inx 2213 18 safe safe JJ cord-010092-uftc8inx 2213 19 . . . cord-010092-uftc8inx 2214 1 In in IN cord-010092-uftc8inx 2214 2 recent recent JJ cord-010092-uftc8inx 2214 3 years year NNS cord-010092-uftc8inx 2214 4 , , , cord-010092-uftc8inx 2214 5 large large JJ cord-010092-uftc8inx 2214 6 - - HYPH cord-010092-uftc8inx 2214 7 scale scale NN cord-010092-uftc8inx 2214 8 blood blood NN cord-010092-uftc8inx 2214 9 donor donor NN cord-010092-uftc8inx 2214 10 cohort cohort NN cord-010092-uftc8inx 2214 11 studies study NNS cord-010092-uftc8inx 2214 12 in in IN cord-010092-uftc8inx 2214 13 several several JJ cord-010092-uftc8inx 2214 14 countries country NNS cord-010092-uftc8inx 2214 15 have have VBP cord-010092-uftc8inx 2214 16 increased increase VBN cord-010092-uftc8inx 2214 17 our -PRON- PRP$ cord-010092-uftc8inx 2214 18 knowledge knowledge NN cord-010092-uftc8inx 2214 19 on on IN cord-010092-uftc8inx 2214 20 health health NN cord-010092-uftc8inx 2214 21 effects effect NNS cord-010092-uftc8inx 2214 22 of of IN cord-010092-uftc8inx 2214 23 blood blood NN cord-010092-uftc8inx 2214 24 donation donation NN cord-010092-uftc8inx 2214 25 . . . cord-010092-uftc8inx 2215 1 Health health NN cord-010092-uftc8inx 2215 2 concerns concern NNS cord-010092-uftc8inx 2215 3 relate relate VBP cord-010092-uftc8inx 2215 4 both both DT cord-010092-uftc8inx 2215 5 to to TO cord-010092-uftc8inx 2215 6 immediate immediate JJ cord-010092-uftc8inx 2215 7 side side NN cord-010092-uftc8inx 2215 8 effects effect NNS cord-010092-uftc8inx 2215 9 like like IN cord-010092-uftc8inx 2215 10 fainting fainting NN cord-010092-uftc8inx 2215 11 and and CC cord-010092-uftc8inx 2215 12 to to IN cord-010092-uftc8inx 2215 13 possible possible JJ cord-010092-uftc8inx 2215 14 long long JJ cord-010092-uftc8inx 2215 15 - - HYPH cord-010092-uftc8inx 2215 16 term term NN cord-010092-uftc8inx 2215 17 health health NN cord-010092-uftc8inx 2215 18 issues issue NNS cord-010092-uftc8inx 2215 19 related relate VBN cord-010092-uftc8inx 2215 20 to to IN cord-010092-uftc8inx 2215 21 repeated repeat VBN cord-010092-uftc8inx 2215 22 blood blood NN cord-010092-uftc8inx 2215 23 or or CC cord-010092-uftc8inx 2215 24 plasma plasma NN cord-010092-uftc8inx 2215 25 donation donation NN cord-010092-uftc8inx 2215 26 . . . cord-010092-uftc8inx 2216 1 The the DT cord-010092-uftc8inx 2216 2 studies study NNS cord-010092-uftc8inx 2216 3 have have VBP cord-010092-uftc8inx 2216 4 provided provide VBN cord-010092-uftc8inx 2216 5 us -PRON- PRP cord-010092-uftc8inx 2216 6 with with IN cord-010092-uftc8inx 2216 7 data datum NNS cord-010092-uftc8inx 2216 8 that that WDT cord-010092-uftc8inx 2216 9 can can MD cord-010092-uftc8inx 2216 10 now now RB cord-010092-uftc8inx 2216 11 help help VB cord-010092-uftc8inx 2216 12 us -PRON- PRP cord-010092-uftc8inx 2216 13 introduce introduce VB cord-010092-uftc8inx 2216 14 an an DT cord-010092-uftc8inx 2216 15 evidence evidence NN cord-010092-uftc8inx 2216 16 - - HYPH cord-010092-uftc8inx 2216 17 based base VBN cord-010092-uftc8inx 2216 18 individualised individualised JJ cord-010092-uftc8inx 2216 19 donor donor NN cord-010092-uftc8inx 2216 20 care care NN cord-010092-uftc8inx 2216 21 -a -a IN cord-010092-uftc8inx 2216 22 parallel parallel JJ cord-010092-uftc8inx 2216 23 to to IN cord-010092-uftc8inx 2216 24 personalised personalised JJ cord-010092-uftc8inx 2216 25 medicine medicine NN cord-010092-uftc8inx 2216 26 . . . cord-010092-uftc8inx 2217 1 Individualised individualised JJ cord-010092-uftc8inx 2217 2 donor donor NN cord-010092-uftc8inx 2217 3 care care NN cord-010092-uftc8inx 2217 4 in in IN cord-010092-uftc8inx 2217 5 the the DT cord-010092-uftc8inx 2217 6 management management NN cord-010092-uftc8inx 2217 7 of of IN cord-010092-uftc8inx 2217 8 iron iron NN cord-010092-uftc8inx 2217 9 depletion depletion NN cord-010092-uftc8inx 2218 1 : : : cord-010092-uftc8inx 2218 2 Studies study NNS cord-010092-uftc8inx 2218 3 have have VBP cord-010092-uftc8inx 2218 4 shown show VBN cord-010092-uftc8inx 2218 5 that that IN cord-010092-uftc8inx 2218 6 a a DT cord-010092-uftc8inx 2218 7 large large JJ cord-010092-uftc8inx 2218 8 percentage percentage NN cord-010092-uftc8inx 2218 9 of of IN cord-010092-uftc8inx 2218 10 our -PRON- PRP$ cord-010092-uftc8inx 2218 11 frequent frequent JJ cord-010092-uftc8inx 2218 12 whole whole JJ cord-010092-uftc8inx 2218 13 blood blood NN cord-010092-uftc8inx 2218 14 donors donor NNS cord-010092-uftc8inx 2218 15 , , , cord-010092-uftc8inx 2218 16 especially especially RB cord-010092-uftc8inx 2218 17 young young JJ cord-010092-uftc8inx 2218 18 women woman NNS cord-010092-uftc8inx 2218 19 , , , cord-010092-uftc8inx 2218 20 are be VBP cord-010092-uftc8inx 2218 21 iron iron NN cord-010092-uftc8inx 2218 22 depleted deplete VBN cord-010092-uftc8inx 2218 23 . . . cord-010092-uftc8inx 2219 1 Iron iron NN cord-010092-uftc8inx 2219 2 depletion depletion NN cord-010092-uftc8inx 2219 3 is be VBZ cord-010092-uftc8inx 2219 4 a a DT cord-010092-uftc8inx 2219 5 strong strong JJ cord-010092-uftc8inx 2219 6 predictor predictor NN cord-010092-uftc8inx 2219 7 of of IN cord-010092-uftc8inx 2219 8 deferral deferral NN cord-010092-uftc8inx 2219 9 for for IN cord-010092-uftc8inx 2219 10 low low JJ cord-010092-uftc8inx 2219 11 haemoglobin haemoglobin NN cord-010092-uftc8inx 2219 12 but but CC cord-010092-uftc8inx 2219 13 has have VBZ cord-010092-uftc8inx 2219 14 also also RB cord-010092-uftc8inx 2219 15 been be VBN cord-010092-uftc8inx 2219 16 associated associate VBN cord-010092-uftc8inx 2219 17 with with IN cord-010092-uftc8inx 2219 18 e.g. e.g. RB cord-010092-uftc8inx 2219 19 restless restless JJ cord-010092-uftc8inx 2219 20 legs leg NNS cord-010092-uftc8inx 2219 21 syndrome syndrome NN cord-010092-uftc8inx 2219 22 and and CC cord-010092-uftc8inx 2219 23 lower low JJR cord-010092-uftc8inx 2219 24 birth birth NN cord-010092-uftc8inx 2219 25 weight weight NN cord-010092-uftc8inx 2219 26 in in IN cord-010092-uftc8inx 2219 27 children child NNS cord-010092-uftc8inx 2219 28 of of IN cord-010092-uftc8inx 2219 29 frequent frequent JJ cord-010092-uftc8inx 2219 30 donors donor NNS cord-010092-uftc8inx 2219 31 . . . cord-010092-uftc8inx 2220 1 The the DT cord-010092-uftc8inx 2220 2 risk risk NN cord-010092-uftc8inx 2220 3 of of IN cord-010092-uftc8inx 2220 4 iron iron NN cord-010092-uftc8inx 2220 5 deficiency deficiency NN cord-010092-uftc8inx 2220 6 can can MD cord-010092-uftc8inx 2220 7 be be VB cord-010092-uftc8inx 2220 8 mitigated mitigate VBN cord-010092-uftc8inx 2220 9 by by IN cord-010092-uftc8inx 2220 10 ferritin ferritin NN cord-010092-uftc8inx 2220 11 - - HYPH cord-010092-uftc8inx 2220 12 guided guide VBN cord-010092-uftc8inx 2220 13 prolongation prolongation NN cord-010092-uftc8inx 2220 14 of of IN cord-010092-uftc8inx 2220 15 interdonation interdonation NN cord-010092-uftc8inx 2220 16 intervals interval NNS cord-010092-uftc8inx 2220 17 or or CC cord-010092-uftc8inx 2220 18 by by IN cord-010092-uftc8inx 2220 19 iron iron NN cord-010092-uftc8inx 2220 20 supplementation supplementation NN cord-010092-uftc8inx 2220 21 . . . cord-010092-uftc8inx 2221 1 Prolongation prolongation NN cord-010092-uftc8inx 2221 2 of of IN cord-010092-uftc8inx 2221 3 interdonation interdonation NN cord-010092-uftc8inx 2221 4 intervals interval NNS cord-010092-uftc8inx 2221 5 can can MD cord-010092-uftc8inx 2221 6 challenge challenge VB cord-010092-uftc8inx 2221 7 our -PRON- PRP$ cord-010092-uftc8inx 2221 8 inventories inventory NNS cord-010092-uftc8inx 2221 9 . . . cord-010092-uftc8inx 2222 1 Iron iron NN cord-010092-uftc8inx 2222 2 supplementation supplementation NN cord-010092-uftc8inx 2222 3 , , , cord-010092-uftc8inx 2222 4 on on IN cord-010092-uftc8inx 2222 5 the the DT cord-010092-uftc8inx 2222 6 other other JJ cord-010092-uftc8inx 2222 7 hand hand NN cord-010092-uftc8inx 2222 8 , , , cord-010092-uftc8inx 2222 9 may may MD cord-010092-uftc8inx 2222 10 give give VB cord-010092-uftc8inx 2222 11 gastrointestinal gastrointestinal JJ cord-010092-uftc8inx 2222 12 side side NN cord-010092-uftc8inx 2222 13 effects effect NNS cord-010092-uftc8inx 2222 14 and and CC cord-010092-uftc8inx 2222 15 other other JJ cord-010092-uftc8inx 2222 16 effects effect NNS cord-010092-uftc8inx 2222 17 have have VBP cord-010092-uftc8inx 2222 18 been be VBN cord-010092-uftc8inx 2222 19 proposed propose VBN cord-010092-uftc8inx 2222 20 as as RB cord-010092-uftc8inx 2222 21 well well RB cord-010092-uftc8inx 2222 22 , , , cord-010092-uftc8inx 2222 23 e.g. e.g. RB cord-010092-uftc8inx 2222 24 the the DT cord-010092-uftc8inx 2222 25 masking masking NN cord-010092-uftc8inx 2222 26 of of IN cord-010092-uftc8inx 2222 27 malignant malignant JJ cord-010092-uftc8inx 2222 28 disease disease NN cord-010092-uftc8inx 2222 29 and and CC cord-010092-uftc8inx 2222 30 increased increase VBN cord-010092-uftc8inx 2222 31 iron iron NN cord-010092-uftc8inx 2222 32 availability availability NN cord-010092-uftc8inx 2222 33 with with IN cord-010092-uftc8inx 2222 34 subsequent subsequent JJ cord-010092-uftc8inx 2222 35 risk risk NN cord-010092-uftc8inx 2222 36 of of IN cord-010092-uftc8inx 2222 37 infection infection NN cord-010092-uftc8inx 2222 38 . . . cord-010092-uftc8inx 2223 1 In in IN cord-010092-uftc8inx 2223 2 a a DT cord-010092-uftc8inx 2223 3 large large JJ cord-010092-uftc8inx 2223 4 study study NN cord-010092-uftc8inx 2223 5 we -PRON- PRP cord-010092-uftc8inx 2223 6 found find VBD cord-010092-uftc8inx 2223 7 that that IN cord-010092-uftc8inx 2223 8 iron iron NN cord-010092-uftc8inx 2223 9 supplementation supplementation NN cord-010092-uftc8inx 2223 10 is be VBZ cord-010092-uftc8inx 2223 11 not not RB cord-010092-uftc8inx 2223 12 associated associate VBN cord-010092-uftc8inx 2223 13 with with IN cord-010092-uftc8inx 2223 14 increased increase VBN cord-010092-uftc8inx 2223 15 risk risk NN cord-010092-uftc8inx 2223 16 of of IN cord-010092-uftc8inx 2223 17 infection infection NN cord-010092-uftc8inx 2223 18 . . . cord-010092-uftc8inx 2224 1 What what WP cord-010092-uftc8inx 2224 2 is be VBZ cord-010092-uftc8inx 2224 3 the the DT cord-010092-uftc8inx 2224 4 optimal optimal JJ cord-010092-uftc8inx 2224 5 balance balance NN cord-010092-uftc8inx 2224 6 between between IN cord-010092-uftc8inx 2224 7 iron iron NN cord-010092-uftc8inx 2224 8 supplementation supplementation NN cord-010092-uftc8inx 2224 9 and and CC cord-010092-uftc8inx 2224 10 prolongation prolongation NN cord-010092-uftc8inx 2224 11 of of IN cord-010092-uftc8inx 2224 12 interdonation interdonation NN cord-010092-uftc8inx 2224 13 intervals interval NNS cord-010092-uftc8inx 2224 14 ? ? . cord-010092-uftc8inx 2225 1 A a DT cord-010092-uftc8inx 2225 2 growing grow VBG cord-010092-uftc8inx 2225 3 number number NN cord-010092-uftc8inx 2225 4 of of IN cord-010092-uftc8inx 2225 5 blood blood NN cord-010092-uftc8inx 2225 6 services service NNS cord-010092-uftc8inx 2225 7 have have VBP cord-010092-uftc8inx 2225 8 implemented implement VBN cord-010092-uftc8inx 2225 9 various various JJ cord-010092-uftc8inx 2225 10 flavours flavour NNS cord-010092-uftc8inx 2225 11 of of IN cord-010092-uftc8inx 2225 12 iron iron NN cord-010092-uftc8inx 2225 13 management management NN cord-010092-uftc8inx 2225 14 regimens regimen NNS cord-010092-uftc8inx 2225 15 generating generate VBG cord-010092-uftc8inx 2225 16 more more JJR cord-010092-uftc8inx 2225 17 results result NNS cord-010092-uftc8inx 2225 18 . . . cord-010092-uftc8inx 2226 1 Moreover moreover RB cord-010092-uftc8inx 2226 2 , , , cord-010092-uftc8inx 2226 3 genetic genetic JJ cord-010092-uftc8inx 2226 4 studies study NNS cord-010092-uftc8inx 2226 5 in in IN cord-010092-uftc8inx 2226 6 e.g. e.g. RB cord-010092-uftc8inx 2226 7 the the DT cord-010092-uftc8inx 2226 8 UK UK NNP cord-010092-uftc8inx 2226 9 , , , cord-010092-uftc8inx 2226 10 US US NNP cord-010092-uftc8inx 2226 11 , , , cord-010092-uftc8inx 2226 12 Holland Holland NNP cord-010092-uftc8inx 2226 13 , , , cord-010092-uftc8inx 2226 14 and and CC cord-010092-uftc8inx 2226 15 Denmark Denmark NNP cord-010092-uftc8inx 2226 16 can can MD cord-010092-uftc8inx 2226 17 help help VB cord-010092-uftc8inx 2226 18 us -PRON- PRP cord-010092-uftc8inx 2226 19 to to TO cord-010092-uftc8inx 2226 20 find find VB cord-010092-uftc8inx 2226 21 donors donor NNS cord-010092-uftc8inx 2226 22 at at IN cord-010092-uftc8inx 2226 23 high high JJ cord-010092-uftc8inx 2226 24 risk risk NN cord-010092-uftc8inx 2226 25 of of IN cord-010092-uftc8inx 2226 26 iron iron NN cord-010092-uftc8inx 2226 27 depletion depletion NN cord-010092-uftc8inx 2226 28 or or CC cord-010092-uftc8inx 2226 29 low low JJ cord-010092-uftc8inx 2226 30 haemoglobin haemoglobin NN cord-010092-uftc8inx 2226 31 . . . cord-010092-uftc8inx 2227 1 We -PRON- PRP cord-010092-uftc8inx 2227 2 can can MD cord-010092-uftc8inx 2227 3 use use VB cord-010092-uftc8inx 2227 4 all all PDT cord-010092-uftc8inx 2227 5 these these DT cord-010092-uftc8inx 2227 6 data datum NNS cord-010092-uftc8inx 2227 7 in in IN cord-010092-uftc8inx 2227 8 a a DT cord-010092-uftc8inx 2227 9 Big Big NNP cord-010092-uftc8inx 2227 10 Data Data NNP cord-010092-uftc8inx 2227 11 approach approach NN cord-010092-uftc8inx 2227 12 in in IN cord-010092-uftc8inx 2227 13 the the DT cord-010092-uftc8inx 2227 14 pursuit pursuit NN cord-010092-uftc8inx 2227 15 of of IN cord-010092-uftc8inx 2227 16 an an DT cord-010092-uftc8inx 2227 17 individualised individualised JJ cord-010092-uftc8inx 2227 18 risk risk NN cord-010092-uftc8inx 2227 19 assessment assessment NN cord-010092-uftc8inx 2227 20 model model NN cord-010092-uftc8inx 2227 21 . . . cord-010092-uftc8inx 2228 1 Other other JJ cord-010092-uftc8inx 2228 2 risks risk NNS cord-010092-uftc8inx 2228 3 for for IN cord-010092-uftc8inx 2228 4 blood blood NN cord-010092-uftc8inx 2228 5 donors donor NNS cord-010092-uftc8inx 2228 6 : : : cord-010092-uftc8inx 2228 7 The the DT cord-010092-uftc8inx 2228 8 presentation presentation NN cord-010092-uftc8inx 2228 9 will will MD cord-010092-uftc8inx 2228 10 also also RB cord-010092-uftc8inx 2228 11 cover cover VB cord-010092-uftc8inx 2228 12 other other JJ cord-010092-uftc8inx 2228 13 risks risk NNS cord-010092-uftc8inx 2228 14 associated associate VBN cord-010092-uftc8inx 2228 15 with with IN cord-010092-uftc8inx 2228 16 donation donation NN cord-010092-uftc8inx 2228 17 . . . cord-010092-uftc8inx 2229 1 New new JJ cord-010092-uftc8inx 2229 2 studies study NNS cord-010092-uftc8inx 2229 3 identify identify VBP cord-010092-uftc8inx 2229 4 predictors predictor NNS cord-010092-uftc8inx 2229 5 of of IN cord-010092-uftc8inx 2229 6 fainting fainting NN cord-010092-uftc8inx 2229 7 after after IN cord-010092-uftc8inx 2229 8 blood blood NN cord-010092-uftc8inx 2229 9 donation donation NN cord-010092-uftc8inx 2229 10 and and CC cord-010092-uftc8inx 2229 11 also also RB cord-010092-uftc8inx 2229 12 new new JJ cord-010092-uftc8inx 2229 13 interventions intervention NNS cord-010092-uftc8inx 2229 14 to to TO cord-010092-uftc8inx 2229 15 prevent prevent VB cord-010092-uftc8inx 2229 16 fainting fainting NN cord-010092-uftc8inx 2229 17 . . . cord-010092-uftc8inx 2230 1 The the DT cord-010092-uftc8inx 2230 2 global global JJ cord-010092-uftc8inx 2230 3 demand demand NN cord-010092-uftc8inx 2230 4 for for IN cord-010092-uftc8inx 2230 5 plasma plasma NN cord-010092-uftc8inx 2230 6 derived derive VBN cord-010092-uftc8inx 2230 7 medicinal medicinal JJ cord-010092-uftc8inx 2230 8 products product NNS cord-010092-uftc8inx 2230 9 has have VBZ cord-010092-uftc8inx 2230 10 increased increase VBN cord-010092-uftc8inx 2230 11 severalfold severalfold RB cord-010092-uftc8inx 2230 12 the the DT cord-010092-uftc8inx 2230 13 last last JJ cord-010092-uftc8inx 2230 14 10 10 CD cord-010092-uftc8inx 2230 15 years year NNS cord-010092-uftc8inx 2230 16 . . . cord-010092-uftc8inx 2231 1 Plasma plasma NN cord-010092-uftc8inx 2231 2 donors donor NNS cord-010092-uftc8inx 2231 3 are be VBP cord-010092-uftc8inx 2231 4 bled bleed VBN cord-010092-uftc8inx 2231 5 up up RP cord-010092-uftc8inx 2231 6 to to TO cord-010092-uftc8inx 2231 7 104 104 CD cord-010092-uftc8inx 2231 8 times time NNS cord-010092-uftc8inx 2231 9 per per IN cord-010092-uftc8inx 2231 10 year year NN cord-010092-uftc8inx 2231 11 in in IN cord-010092-uftc8inx 2231 12 the the DT cord-010092-uftc8inx 2231 13 US US NNP cord-010092-uftc8inx 2231 14 . . . cord-010092-uftc8inx 2232 1 Very very RB cord-010092-uftc8inx 2232 2 little little JJ cord-010092-uftc8inx 2232 3 is be VBZ cord-010092-uftc8inx 2232 4 known know VBN cord-010092-uftc8inx 2232 5 about about IN cord-010092-uftc8inx 2232 6 the the DT cord-010092-uftc8inx 2232 7 health health NN cord-010092-uftc8inx 2232 8 effects effect NNS cord-010092-uftc8inx 2232 9 of of IN cord-010092-uftc8inx 2232 10 frequent frequent JJ cord-010092-uftc8inx 2232 11 plasma plasma NN cord-010092-uftc8inx 2232 12 donation donation NN cord-010092-uftc8inx 2232 13 . . . cord-010092-uftc8inx 2233 1 We -PRON- PRP cord-010092-uftc8inx 2233 2 know know VBP cord-010092-uftc8inx 2233 3 that that IN cord-010092-uftc8inx 2233 4 immunoglobulin immunoglobulin NN cord-010092-uftc8inx 2233 5 levels level NNS cord-010092-uftc8inx 2233 6 decrease decrease VBP cord-010092-uftc8inx 2233 7 with with IN cord-010092-uftc8inx 2233 8 frequent frequent JJ cord-010092-uftc8inx 2233 9 donation donation NN cord-010092-uftc8inx 2234 1 but but CC cord-010092-uftc8inx 2234 2 how how WRB cord-010092-uftc8inx 2234 3 does do VBZ cord-010092-uftc8inx 2234 4 this this DT cord-010092-uftc8inx 2234 5 affect affect VB cord-010092-uftc8inx 2234 6 health health NN cord-010092-uftc8inx 2234 7 ? ? . cord-010092-uftc8inx 2235 1 Summary Summary NNP cord-010092-uftc8inx 2235 2 / / SYM cord-010092-uftc8inx 2235 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 2235 4 : : : cord-010092-uftc8inx 2236 1 The the DT cord-010092-uftc8inx 2236 2 precautionary precautionary JJ cord-010092-uftc8inx 2236 3 principle principle NN cord-010092-uftc8inx 2236 4 mitigates mitigate VBZ cord-010092-uftc8inx 2236 5 risk risk NN cord-010092-uftc8inx 2236 6 through through IN cord-010092-uftc8inx 2236 7 early early JJ cord-010092-uftc8inx 2236 8 intervention intervention NN cord-010092-uftc8inx 2236 9 prior prior RB cord-010092-uftc8inx 2236 10 to to IN cord-010092-uftc8inx 2236 11 evidence evidence NN cord-010092-uftc8inx 2236 12 . . . cord-010092-uftc8inx 2237 1 We -PRON- PRP cord-010092-uftc8inx 2237 2 tolerate tolerate VBP cord-010092-uftc8inx 2237 3 next next RB cord-010092-uftc8inx 2237 4 to to IN cord-010092-uftc8inx 2237 5 no no DT cord-010092-uftc8inx 2237 6 risk risk NN cord-010092-uftc8inx 2237 7 of of IN cord-010092-uftc8inx 2237 8 transfusion transfusion NN cord-010092-uftc8inx 2237 9 - - HYPH cord-010092-uftc8inx 2237 10 transmitted transmit VBN cord-010092-uftc8inx 2237 11 infectious infectious JJ cord-010092-uftc8inx 2237 12 diseases disease NNS cord-010092-uftc8inx 2237 13 . . . cord-010092-uftc8inx 2238 1 The the DT cord-010092-uftc8inx 2238 2 health health NN cord-010092-uftc8inx 2238 3 of of IN cord-010092-uftc8inx 2238 4 the the DT cord-010092-uftc8inx 2238 5 blood blood NN cord-010092-uftc8inx 2238 6 donors donor NNS cord-010092-uftc8inx 2238 7 , , , cord-010092-uftc8inx 2238 8 however however RB cord-010092-uftc8inx 2238 9 , , , cord-010092-uftc8inx 2238 10 has have VBZ cord-010092-uftc8inx 2238 11 not not RB cord-010092-uftc8inx 2238 12 been be VBN cord-010092-uftc8inx 2238 13 protected protect VBN cord-010092-uftc8inx 2238 14 similarly similarly RB cord-010092-uftc8inx 2238 15 . . . cord-010092-uftc8inx 2239 1 We -PRON- PRP cord-010092-uftc8inx 2239 2 owe owe VBP cord-010092-uftc8inx 2239 3 to to IN cord-010092-uftc8inx 2239 4 our -PRON- PRP$ cord-010092-uftc8inx 2239 5 whole whole JJ cord-010092-uftc8inx 2239 6 blood blood NN cord-010092-uftc8inx 2239 7 and and CC cord-010092-uftc8inx 2239 8 plasma plasma NN cord-010092-uftc8inx 2239 9 donors donor NNS cord-010092-uftc8inx 2239 10 to to TO cord-010092-uftc8inx 2239 11 investigate investigate VB cord-010092-uftc8inx 2239 12 health health NN cord-010092-uftc8inx 2239 13 effects effect NNS cord-010092-uftc8inx 2239 14 of of IN cord-010092-uftc8inx 2239 15 blood blood NN cord-010092-uftc8inx 2239 16 donation donation NN cord-010092-uftc8inx 2239 17 and and CC cord-010092-uftc8inx 2239 18 ensure ensure VB cord-010092-uftc8inx 2239 19 their -PRON- PRP$ cord-010092-uftc8inx 2239 20 safety safety NN cord-010092-uftc8inx 2239 21 . . . cord-010092-uftc8inx 2240 1 While while IN cord-010092-uftc8inx 2240 2 the the DT cord-010092-uftc8inx 2240 3 first first JJ cord-010092-uftc8inx 2240 4 attempts attempt NNS cord-010092-uftc8inx 2240 5 may may MD cord-010092-uftc8inx 2240 6 not not RB cord-010092-uftc8inx 2240 7 be be VB cord-010092-uftc8inx 2240 8 perfect perfect JJ cord-010092-uftc8inx 2240 9 , , , cord-010092-uftc8inx 2240 10 we -PRON- PRP cord-010092-uftc8inx 2240 11 now now RB cord-010092-uftc8inx 2240 12 have have VBP cord-010092-uftc8inx 2240 13 the the DT cord-010092-uftc8inx 2240 14 tools tool NNS cord-010092-uftc8inx 2240 15 to to TO cord-010092-uftc8inx 2240 16 construct construct VB cord-010092-uftc8inx 2240 17 models model NNS cord-010092-uftc8inx 2240 18 for for IN cord-010092-uftc8inx 2240 19 individualised individualised JJ cord-010092-uftc8inx 2240 20 donor donor NN cord-010092-uftc8inx 2240 21 care care NN cord-010092-uftc8inx 2240 22 . . . cord-010092-uftc8inx 2241 1 Background background NN cord-010092-uftc8inx 2241 2 : : : cord-010092-uftc8inx 2242 1 In in IN cord-010092-uftc8inx 2242 2 2014 2014 CD cord-010092-uftc8inx 2242 3 , , , cord-010092-uftc8inx 2242 4 the the DT cord-010092-uftc8inx 2242 5 ISBT ISBT NNP cord-010092-uftc8inx 2242 6 , , , cord-010092-uftc8inx 2242 7 AABB AABB NNP cord-010092-uftc8inx 2242 8 , , , cord-010092-uftc8inx 2242 9 IHN IHN NNP cord-010092-uftc8inx 2242 10 and and CC cord-010092-uftc8inx 2242 11 EBA EBA NNP cord-010092-uftc8inx 2242 12 jointly jointly RB cord-010092-uftc8inx 2242 13 issued issue VBD cord-010092-uftc8inx 2242 14 the the DT cord-010092-uftc8inx 2242 15 Standard Standard NNP cord-010092-uftc8inx 2242 16 for for IN cord-010092-uftc8inx 2242 17 Surveillance Surveillance NNP cord-010092-uftc8inx 2242 18 of of IN cord-010092-uftc8inx 2242 19 Complications complication NNS cord-010092-uftc8inx 2242 20 Related relate VBN cord-010092-uftc8inx 2242 21 to to IN cord-010092-uftc8inx 2242 22 Blood Blood NNP cord-010092-uftc8inx 2242 23 Donation Donation NNP cord-010092-uftc8inx 2242 24 which which WDT cord-010092-uftc8inx 2242 25 categorized categorize VBD cord-010092-uftc8inx 2242 26 Donor Donor NNP cord-010092-uftc8inx 2242 27 Adverse adverse JJ cord-010092-uftc8inx 2242 28 Events event NNS cord-010092-uftc8inx 2242 29 ( ( -LRB- cord-010092-uftc8inx 2242 30 DAE DAE NNP cord-010092-uftc8inx 2242 31 ) ) -RRB- cord-010092-uftc8inx 2242 32 into into IN cord-010092-uftc8inx 2242 33 6 6 CD cord-010092-uftc8inx 2242 34 categories category NNS cord-010092-uftc8inx 2242 35 ( ( -LRB- cord-010092-uftc8inx 2242 36 16 16 CD cord-010092-uftc8inx 2242 37 subcategories subcategorie NNS cord-010092-uftc8inx 2242 38 ) ) -RRB- cord-010092-uftc8inx 2242 39 defined define VBN cord-010092-uftc8inx 2242 40 by by IN cord-010092-uftc8inx 2242 41 specific specific JJ cord-010092-uftc8inx 2242 42 criteria criterion NNS cord-010092-uftc8inx 2242 43 . . . cord-010092-uftc8inx 2243 1 Severity severity NN cord-010092-uftc8inx 2243 2 and and CC cord-010092-uftc8inx 2243 3 Imputability Imputability NNP cord-010092-uftc8inx 2243 4 were be VBD cord-010092-uftc8inx 2243 5 briefly briefly RB cord-010092-uftc8inx 2243 6 described describe VBN cord-010092-uftc8inx 2243 7 but but CC cord-010092-uftc8inx 2243 8 were be VBD cord-010092-uftc8inx 2243 9 optional optional JJ cord-010092-uftc8inx 2243 10 . . . cord-010092-uftc8inx 2244 1 Subsequent subsequent JJ cord-010092-uftc8inx 2244 2 validation validation NN cord-010092-uftc8inx 2244 3 of of IN cord-010092-uftc8inx 2244 4 these these DT cord-010092-uftc8inx 2244 5 categories category NNS cord-010092-uftc8inx 2244 6 demonstrated demonstrate VBD cord-010092-uftc8inx 2244 7 consistency consistency NN cord-010092-uftc8inx 2244 8 in in IN cord-010092-uftc8inx 2244 9 categorizing categorize VBG cord-010092-uftc8inx 2244 10 reactions reaction NNS cord-010092-uftc8inx 2244 11 , , , cord-010092-uftc8inx 2244 12 but but CC cord-010092-uftc8inx 2244 13 wide wide JJ cord-010092-uftc8inx 2244 14 variation variation NN cord-010092-uftc8inx 2244 15 in in IN cord-010092-uftc8inx 2244 16 assignment assignment NN cord-010092-uftc8inx 2244 17 of of IN cord-010092-uftc8inx 2244 18 Severity severity NN cord-010092-uftc8inx 2244 19 . . . cord-010092-uftc8inx 2245 1 In in IN cord-010092-uftc8inx 2245 2 2018 2018 CD cord-010092-uftc8inx 2245 3 , , , cord-010092-uftc8inx 2245 4 with with IN cord-010092-uftc8inx 2245 5 international international JJ cord-010092-uftc8inx 2245 6 input input NN cord-010092-uftc8inx 2245 7 , , , cord-010092-uftc8inx 2245 8 the the DT cord-010092-uftc8inx 2245 9 AABB AABB NNP cord-010092-uftc8inx 2245 10 Donor Donor NNP cord-010092-uftc8inx 2245 11 Biovigilance Biovigilance NNP cord-010092-uftc8inx 2245 12 Committee Committee NNP cord-010092-uftc8inx 2245 13 developed develop VBD cord-010092-uftc8inx 2245 14 a a DT cord-010092-uftc8inx 2245 15 Severity severity NN cord-010092-uftc8inx 2245 16 Grading Grading NNP cord-010092-uftc8inx 2245 17 Tool tool NN cord-010092-uftc8inx 2245 18 ( ( -LRB- cord-010092-uftc8inx 2245 19 SGT SGT NNP cord-010092-uftc8inx 2245 20 ) ) -RRB- cord-010092-uftc8inx 2245 21 using use VBG cord-010092-uftc8inx 2245 22 a a DT cord-010092-uftc8inx 2245 23 recognized recognize VBN cord-010092-uftc8inx 2245 24 medical medical JJ cord-010092-uftc8inx 2245 25 adverse adverse JJ cord-010092-uftc8inx 2245 26 event event NN cord-010092-uftc8inx 2245 27 grading grading NN cord-010092-uftc8inx 2245 28 system system NN cord-010092-uftc8inx 2245 29 in in IN cord-010092-uftc8inx 2245 30 which which WDT cord-010092-uftc8inx 2245 31 neutral neutral JJ cord-010092-uftc8inx 2245 32 Grades grade NNS cord-010092-uftc8inx 2245 33 replace replace VBP cord-010092-uftc8inx 2245 34 subjective subjective JJ cord-010092-uftc8inx 2245 35 terms term NNS cord-010092-uftc8inx 2245 36 ( ( -LRB- cord-010092-uftc8inx 2245 37 mild mild JJ cord-010092-uftc8inx 2245 38 , , , cord-010092-uftc8inx 2245 39 moderate moderate JJ cord-010092-uftc8inx 2245 40 , , , cord-010092-uftc8inx 2245 41 severe severe JJ cord-010092-uftc8inx 2245 42 ) ) -RRB- cord-010092-uftc8inx 2245 43 . . . cord-010092-uftc8inx 2246 1 Aims aim VBZ cord-010092-uftc8inx 2246 2 : : : cord-010092-uftc8inx 2247 1 A a DT cord-010092-uftc8inx 2247 2 large large JJ cord-010092-uftc8inx 2247 3 US US NNP cord-010092-uftc8inx 2247 4 blood blood NN cord-010092-uftc8inx 2247 5 collection collection NN cord-010092-uftc8inx 2247 6 establishment establishment NN cord-010092-uftc8inx 2247 7 ( ( -LRB- cord-010092-uftc8inx 2247 8 BCE BCE NNP cord-010092-uftc8inx 2247 9 ) ) -RRB- cord-010092-uftc8inx 2247 10 applied apply VBD cord-010092-uftc8inx 2247 11 the the DT cord-010092-uftc8inx 2247 12 draft draft NN cord-010092-uftc8inx 2247 13 SGT SGT NNP cord-010092-uftc8inx 2247 14 to to TO cord-010092-uftc8inx 2247 15 assess assess VB cord-010092-uftc8inx 2247 16 its -PRON- PRP$ cord-010092-uftc8inx 2247 17 use use NN cord-010092-uftc8inx 2247 18 in in IN cord-010092-uftc8inx 2247 19 real real JJ cord-010092-uftc8inx 2247 20 cases case NNS cord-010092-uftc8inx 2247 21 of of IN cord-010092-uftc8inx 2247 22 DAE DAE NNP cord-010092-uftc8inx 2247 23 . . . cord-010092-uftc8inx 2248 1 Methods method NNS cord-010092-uftc8inx 2248 2 : : : cord-010092-uftc8inx 2249 1 We -PRON- PRP cord-010092-uftc8inx 2249 2 performed perform VBD cord-010092-uftc8inx 2249 3 retrospective retrospective JJ cord-010092-uftc8inx 2249 4 analysis analysis NN cord-010092-uftc8inx 2249 5 of of IN cord-010092-uftc8inx 2249 6 all all DT cord-010092-uftc8inx 2249 7 allogeneic allogeneic NN cord-010092-uftc8inx 2249 8 and and CC cord-010092-uftc8inx 2249 9 apheresis apheresis NN cord-010092-uftc8inx 2249 10 needle needle NN cord-010092-uftc8inx 2249 11 - - HYPH cord-010092-uftc8inx 2249 12 in in IN cord-010092-uftc8inx 2249 13 donations donation NNS cord-010092-uftc8inx 2249 14 between between IN cord-010092-uftc8inx 2249 15 1/1/2017 1/1/2017 CD cord-010092-uftc8inx 2249 16 to to IN cord-010092-uftc8inx 2249 17 9/30/2018 9/30/2018 CD cord-010092-uftc8inx 2249 18 . . . cord-010092-uftc8inx 2250 1 Severity severity NN cord-010092-uftc8inx 2250 2 grading grading NN cord-010092-uftc8inx 2250 3 was be VBD cord-010092-uftc8inx 2250 4 assigned assign VBN cord-010092-uftc8inx 2250 5 based base VBN cord-010092-uftc8inx 2250 6 on on IN cord-010092-uftc8inx 2250 7 criteria criterion NNS cord-010092-uftc8inx 2250 8 defined define VBN cord-010092-uftc8inx 2250 9 by by IN cord-010092-uftc8inx 2250 10 the the DT cord-010092-uftc8inx 2250 11 SGT SGT NNP cord-010092-uftc8inx 2250 12 . . . cord-010092-uftc8inx 2251 1 Database database NN cord-010092-uftc8inx 2251 2 review review NN cord-010092-uftc8inx 2251 3 of of IN cord-010092-uftc8inx 2251 4 DAE DAE NNP cord-010092-uftc8inx 2251 5 was be VBD cord-010092-uftc8inx 2251 6 performed perform VBN cord-010092-uftc8inx 2251 7 , , , cord-010092-uftc8inx 2251 8 and and CC cord-010092-uftc8inx 2251 9 each each DT cord-010092-uftc8inx 2251 10 event event NN cord-010092-uftc8inx 2251 11 was be VBD cord-010092-uftc8inx 2251 12 assigned assign VBN cord-010092-uftc8inx 2251 13 a a DT cord-010092-uftc8inx 2251 14 Grade grade NN cord-010092-uftc8inx 2251 15 based base VBN cord-010092-uftc8inx 2251 16 on on IN cord-010092-uftc8inx 2251 17 the the DT cord-010092-uftc8inx 2251 18 type type NN cord-010092-uftc8inx 2251 19 of of IN cord-010092-uftc8inx 2251 20 outside outside JJ cord-010092-uftc8inx 2251 21 medical medical JJ cord-010092-uftc8inx 2251 22 care care NN cord-010092-uftc8inx 2251 23 ( ( -LRB- cord-010092-uftc8inx 2251 24 OMC OMC NNP cord-010092-uftc8inx 2251 25 ) ) -RRB- cord-010092-uftc8inx 2251 26 , , , cord-010092-uftc8inx 2251 27 and and CC cord-010092-uftc8inx 2251 28 on on IN cord-010092-uftc8inx 2251 29 specific specific JJ cord-010092-uftc8inx 2251 30 key key JJ cord-010092-uftc8inx 2251 31 search search NN cord-010092-uftc8inx 2251 32 terms term NNS cord-010092-uftc8inx 2251 33 . . . cord-010092-uftc8inx 2252 1 Search search NN cord-010092-uftc8inx 2252 2 terms term NNS cord-010092-uftc8inx 2252 3 for for IN cord-010092-uftc8inx 2252 4 OMC OMC NNP cord-010092-uftc8inx 2252 5 included include VBD cord-010092-uftc8inx 2252 6 Emergency Emergency NNP cord-010092-uftc8inx 2252 7 Room Room NNP cord-010092-uftc8inx 2252 8 , , , cord-010092-uftc8inx 2252 9 Emergency Emergency NNP cord-010092-uftc8inx 2252 10 Medical Medical NNP cord-010092-uftc8inx 2252 11 Response Response NNP cord-010092-uftc8inx 2252 12 , , , cord-010092-uftc8inx 2252 13 Urgent Urgent NNP cord-010092-uftc8inx 2252 14 Care Care NNP cord-010092-uftc8inx 2252 15 , , , cord-010092-uftc8inx 2252 16 Healthcare Healthcare NNP cord-010092-uftc8inx 2252 17 Professional Professional NNP cord-010092-uftc8inx 2252 18 , , , cord-010092-uftc8inx 2252 19 and and CC cord-010092-uftc8inx 2252 20 Hospital Hospital NNP cord-010092-uftc8inx 2252 21 Admission Admission NNP cord-010092-uftc8inx 2252 22 . . . cord-010092-uftc8inx 2253 1 Additional additional JJ cord-010092-uftc8inx 2253 2 specific specific JJ cord-010092-uftc8inx 2253 3 key key JJ cord-010092-uftc8inx 2253 4 search search NN cord-010092-uftc8inx 2253 5 terms term NNS cord-010092-uftc8inx 2253 6 included include VBD cord-010092-uftc8inx 2253 7 fracture fracture NN cord-010092-uftc8inx 2253 8 , , , cord-010092-uftc8inx 2253 9 concussion concussion NN cord-010092-uftc8inx 2253 10 , , , cord-010092-uftc8inx 2253 11 laceration laceration NN cord-010092-uftc8inx 2253 12 , , , cord-010092-uftc8inx 2253 13 dental dental JJ cord-010092-uftc8inx 2253 14 injury injury NN cord-010092-uftc8inx 2253 15 , , , cord-010092-uftc8inx 2253 16 surgery surgery NN cord-010092-uftc8inx 2253 17 , , , cord-010092-uftc8inx 2253 18 and and CC cord-010092-uftc8inx 2253 19 hospitalization hospitalization NN cord-010092-uftc8inx 2253 20 . . . cord-010092-uftc8inx 2254 1 Since since IN cord-010092-uftc8inx 2254 2 duration duration NN cord-010092-uftc8inx 2254 3 and and CC cord-010092-uftc8inx 2254 4 activities activity NNS cord-010092-uftc8inx 2254 5 of of IN cord-010092-uftc8inx 2254 6 daily daily JJ cord-010092-uftc8inx 2254 7 living live VBG cord-010092-uftc8inx 2254 8 ( ( -LRB- cord-010092-uftc8inx 2254 9 ADL ADL NNP cord-010092-uftc8inx 2254 10 ) ) -RRB- cord-010092-uftc8inx 2254 11 limitations limitation NNS cord-010092-uftc8inx 2254 12 were be VBD cord-010092-uftc8inx 2254 13 not not RB cord-010092-uftc8inx 2254 14 captured capture VBN cord-010092-uftc8inx 2254 15 in in IN cord-010092-uftc8inx 2254 16 our -PRON- PRP$ cord-010092-uftc8inx 2254 17 DAE DAE NNP cord-010092-uftc8inx 2254 18 database database NN cord-010092-uftc8inx 2254 19 , , , cord-010092-uftc8inx 2254 20 cases case NNS cord-010092-uftc8inx 2254 21 in in IN cord-010092-uftc8inx 2254 22 our -PRON- PRP$ cord-010092-uftc8inx 2254 23 DAE DAE NNP cord-010092-uftc8inx 2254 24 claims claim NNS cord-010092-uftc8inx 2254 25 ' ' POS cord-010092-uftc8inx 2254 26 database database NN cord-010092-uftc8inx 2254 27 were be VBD cord-010092-uftc8inx 2254 28 reviewed review VBN cord-010092-uftc8inx 2254 29 . . . cord-010092-uftc8inx 2255 1 Case case NN cord-010092-uftc8inx 2255 2 files file NNS cord-010092-uftc8inx 2255 3 of of IN cord-010092-uftc8inx 2255 4 events event NNS cord-010092-uftc8inx 2255 5 classified classify VBN cord-010092-uftc8inx 2255 6 as as IN cord-010092-uftc8inx 2255 7 Grade grade NN cord-010092-uftc8inx 2255 8 2 2 CD cord-010092-uftc8inx 2255 9 or or CC cord-010092-uftc8inx 2255 10 higher high JJR cord-010092-uftc8inx 2255 11 were be VBD cord-010092-uftc8inx 2255 12 individually individually RB cord-010092-uftc8inx 2255 13 evaluated evaluate VBN cord-010092-uftc8inx 2255 14 by by IN cord-010092-uftc8inx 2255 15 a a DT cord-010092-uftc8inx 2255 16 physician physician NN cord-010092-uftc8inx 2255 17 for for IN cord-010092-uftc8inx 2255 18 grading grading NN cord-010092-uftc8inx 2255 19 accuracy accuracy NN cord-010092-uftc8inx 2255 20 . . . cord-010092-uftc8inx 2256 1 Results result NNS cord-010092-uftc8inx 2256 2 : : : cord-010092-uftc8inx 2257 1 In in IN cord-010092-uftc8inx 2257 2 1,511,758 1,511,758 CD cord-010092-uftc8inx 2257 3 needle needle NN cord-010092-uftc8inx 2257 4 - - HYPH cord-010092-uftc8inx 2257 5 in in RP cord-010092-uftc8inx 2257 6 collections collection NNS cord-010092-uftc8inx 2257 7 , , , cord-010092-uftc8inx 2257 8 31,320 31,320 CD cord-010092-uftc8inx 2257 9 DAE DAE NNP cord-010092-uftc8inx 2257 10 were be VBD cord-010092-uftc8inx 2257 11 graded grade VBN cord-010092-uftc8inx 2257 12 for for IN cord-010092-uftc8inx 2257 13 severity severity NN cord-010092-uftc8inx 2257 14 . . . cord-010092-uftc8inx 2258 1 The the DT cord-010092-uftc8inx 2258 2 majority majority NN cord-010092-uftc8inx 2258 3 ( ( -LRB- cord-010092-uftc8inx 2258 4 16,143 16,143 CD cord-010092-uftc8inx 2258 5 , , , cord-010092-uftc8inx 2258 6 51.5 51.5 CD cord-010092-uftc8inx 2258 7 % % NN cord-010092-uftc8inx 2258 8 ) ) -RRB- cord-010092-uftc8inx 2258 9 were be VBD cord-010092-uftc8inx 2258 10 vasovagal vasovagal JJ cord-010092-uftc8inx 2258 11 reactions reaction NNS cord-010092-uftc8inx 2258 12 ( ( -LRB- cord-010092-uftc8inx 2258 13 VVR vvr NN cord-010092-uftc8inx 2258 14 ) ) -RRB- cord-010092-uftc8inx 2258 15 , , , cord-010092-uftc8inx 2258 16 followed follow VBN cord-010092-uftc8inx 2258 17 by by IN cord-010092-uftc8inx 2258 18 8,570 8,570 CD cord-010092-uftc8inx 2258 19 apheresis apheresis NN cord-010092-uftc8inx 2258 20 - - HYPH cord-010092-uftc8inx 2258 21 related relate VBN cord-010092-uftc8inx 2258 22 ( ( -LRB- cord-010092-uftc8inx 2258 23 27.4 27.4 CD cord-010092-uftc8inx 2258 24 % % NN cord-010092-uftc8inx 2258 25 ) ) -RRB- cord-010092-uftc8inx 2258 26 , , , cord-010092-uftc8inx 2258 27 6,572 6,572 CD cord-010092-uftc8inx 2258 28 needle needle NN cord-010092-uftc8inx 2258 29 - - HYPH cord-010092-uftc8inx 2258 30 related relate VBN cord-010092-uftc8inx 2258 31 ( ( -LRB- cord-010092-uftc8inx 2258 32 21.0 21.0 CD cord-010092-uftc8inx 2258 33 % % NN cord-010092-uftc8inx 2258 34 ) ) -RRB- cord-010092-uftc8inx 2258 35 and and CC cord-010092-uftc8inx 2258 36 35 35 CD cord-010092-uftc8inx 2258 37 allergic allergic JJ cord-010092-uftc8inx 2258 38 ( ( -LRB- cord-010092-uftc8inx 2258 39 0.1 0.1 CD cord-010092-uftc8inx 2258 40 % % NN cord-010092-uftc8inx 2258 41 ) ) -RRB- cord-010092-uftc8inx 2258 42 events event NNS cord-010092-uftc8inx 2258 43 . . . cord-010092-uftc8inx 2259 1 The the DT cord-010092-uftc8inx 2259 2 majority majority NN cord-010092-uftc8inx 2259 3 of of IN cord-010092-uftc8inx 2259 4 DAE DAE NNP cord-010092-uftc8inx 2259 5 were be VBD cord-010092-uftc8inx 2259 6 Grade Grade NNP cord-010092-uftc8inx 2259 7 1 1 CD cord-010092-uftc8inx 2259 8 accounting account VBG cord-010092-uftc8inx 2259 9 for for IN cord-010092-uftc8inx 2259 10 98.6 98.6 CD cord-010092-uftc8inx 2259 11 % % NN cord-010092-uftc8inx 2259 12 of of IN cord-010092-uftc8inx 2259 13 all all DT cord-010092-uftc8inx 2259 14 DAE DAE NNP cord-010092-uftc8inx 2259 15 , , , cord-010092-uftc8inx 2259 16 followed follow VBN cord-010092-uftc8inx 2259 17 by by IN cord-010092-uftc8inx 2259 18 Grade grade NN cord-010092-uftc8inx 2259 19 2 2 CD cord-010092-uftc8inx 2259 20 ( ( -LRB- cord-010092-uftc8inx 2259 21 1.2 1.2 CD cord-010092-uftc8inx 2259 22 % % NN cord-010092-uftc8inx 2259 23 ) ) -RRB- cord-010092-uftc8inx 2259 24 , , , cord-010092-uftc8inx 2259 25 and and CC cord-010092-uftc8inx 2259 26 Grade Grade NNP cord-010092-uftc8inx 2259 27 3 3 CD cord-010092-uftc8inx 2259 28 ( ( -LRB- cord-010092-uftc8inx 2259 29 0.1 0.1 CD cord-010092-uftc8inx 2259 30 % % NN cord-010092-uftc8inx 2259 31 ) ) -RRB- cord-010092-uftc8inx 2259 32 . . . cord-010092-uftc8inx 2260 1 There there EX cord-010092-uftc8inx 2260 2 were be VBD cord-010092-uftc8inx 2260 3 2 2 CD cord-010092-uftc8inx 2260 4 Grade grade NN cord-010092-uftc8inx 2260 5 4 4 CD cord-010092-uftc8inx 2260 6 and and CC cord-010092-uftc8inx 2260 7 no no DT cord-010092-uftc8inx 2260 8 Grade grade NN cord-010092-uftc8inx 2260 9 5 5 CD cord-010092-uftc8inx 2260 10 DAE DAE NNP cord-010092-uftc8inx 2260 11 . . . cord-010092-uftc8inx 2261 1 Among among IN cord-010092-uftc8inx 2261 2 the the DT cord-010092-uftc8inx 2261 3 VVR vvr NN cord-010092-uftc8inx 2261 4 , , , cord-010092-uftc8inx 2261 5 98.1 98.1 CD cord-010092-uftc8inx 2261 6 % % NN cord-010092-uftc8inx 2261 7 , , , cord-010092-uftc8inx 2261 8 1.6 1.6 CD cord-010092-uftc8inx 2261 9 % % NN cord-010092-uftc8inx 2261 10 , , , cord-010092-uftc8inx 2261 11 0.2 0.2 CD cord-010092-uftc8inx 2261 12 % % NN cord-010092-uftc8inx 2261 13 and and CC cord-010092-uftc8inx 2261 14 0.01 0.01 CD cord-010092-uftc8inx 2261 15 % % NN cord-010092-uftc8inx 2261 16 were be VBD cord-010092-uftc8inx 2261 17 Grade grade NN cord-010092-uftc8inx 2261 18 1 1 CD cord-010092-uftc8inx 2261 19 , , , cord-010092-uftc8inx 2261 20 2 2 CD cord-010092-uftc8inx 2261 21 , , , cord-010092-uftc8inx 2261 22 3 3 CD cord-010092-uftc8inx 2261 23 , , , cord-010092-uftc8inx 2261 24 and and CC cord-010092-uftc8inx 2261 25 4 4 CD cord-010092-uftc8inx 2261 26 respectively respectively RB cord-010092-uftc8inx 2261 27 . . . cord-010092-uftc8inx 2262 1 Grade grade NN cord-010092-uftc8inx 2262 2 3 3 CD cord-010092-uftc8inx 2262 3 VVRs vvr NNS cord-010092-uftc8inx 2262 4 included include VBD cord-010092-uftc8inx 2262 5 14 14 CD cord-010092-uftc8inx 2262 6 concussions concussion NNS cord-010092-uftc8inx 2262 7 , , , cord-010092-uftc8inx 2262 8 11 11 CD cord-010092-uftc8inx 2262 9 fractures fracture NNS cord-010092-uftc8inx 2262 10 , , , cord-010092-uftc8inx 2262 11 1 1 CD cord-010092-uftc8inx 2262 12 dental dental JJ cord-010092-uftc8inx 2262 13 injury injury NN cord-010092-uftc8inx 2262 14 , , , cord-010092-uftc8inx 2262 15 and and CC cord-010092-uftc8inx 2262 16 2 2 CD cord-010092-uftc8inx 2262 17 pre pre JJ cord-010092-uftc8inx 2262 18 - - JJ cord-010092-uftc8inx 2262 19 faint faint JJ cord-010092-uftc8inx 2262 20 and and CC cord-010092-uftc8inx 2262 21 8 8 CD cord-010092-uftc8inx 2262 22 fainting fainting NN cord-010092-uftc8inx 2262 23 events event NNS cord-010092-uftc8inx 2262 24 requiring require VBG cord-010092-uftc8inx 2262 25 hospitalization hospitalization NN cord-010092-uftc8inx 2262 26 for for IN cord-010092-uftc8inx 2262 27 work work NN cord-010092-uftc8inx 2262 28 - - HYPH cord-010092-uftc8inx 2262 29 up up NN cord-010092-uftc8inx 2262 30 . . . cord-010092-uftc8inx 2263 1 Two two CD cord-010092-uftc8inx 2263 2 Grade grade NN cord-010092-uftc8inx 2263 3 4 4 CD cord-010092-uftc8inx 2263 4 VVRs vvrs NN cord-010092-uftc8inx 2263 5 involved involve VBN cord-010092-uftc8inx 2263 6 falls fall VBZ cord-010092-uftc8inx 2263 7 resulting result VBG cord-010092-uftc8inx 2263 8 in in IN cord-010092-uftc8inx 2263 9 intracranial intracranial JJ cord-010092-uftc8inx 2263 10 hemorrhage hemorrhage NN cord-010092-uftc8inx 2263 11 requiring require VBG cord-010092-uftc8inx 2263 12 immediate immediate JJ cord-010092-uftc8inx 2263 13 medical medical JJ cord-010092-uftc8inx 2263 14 intervention intervention NN cord-010092-uftc8inx 2263 15 . . . cord-010092-uftc8inx 2264 1 For for IN cord-010092-uftc8inx 2264 2 allergic allergic JJ cord-010092-uftc8inx 2264 3 and and CC cord-010092-uftc8inx 2264 4 apheresis apheresis NN cord-010092-uftc8inx 2264 5 DAE DAE NNP cord-010092-uftc8inx 2264 6 , , , cord-010092-uftc8inx 2264 7 there there EX cord-010092-uftc8inx 2264 8 were be VBD cord-010092-uftc8inx 2264 9 only only RB cord-010092-uftc8inx 2264 10 6 6 CD cord-010092-uftc8inx 2264 11 and and CC cord-010092-uftc8inx 2264 12 5 5 CD cord-010092-uftc8inx 2264 13 Grade grade NN cord-010092-uftc8inx 2264 14 2 2 CD cord-010092-uftc8inx 2264 15 reactions reaction NNS cord-010092-uftc8inx 2264 16 respectively respectively RB cord-010092-uftc8inx 2264 17 , , , cord-010092-uftc8inx 2264 18 and and CC cord-010092-uftc8inx 2264 19 no no DT cord-010092-uftc8inx 2264 20 Grade Grade NNP cord-010092-uftc8inx 2264 21 3 3 CD cord-010092-uftc8inx 2264 22 or or CC cord-010092-uftc8inx 2264 23 4 4 CD cord-010092-uftc8inx 2264 24 events event NNS cord-010092-uftc8inx 2264 25 . . . cord-010092-uftc8inx 2265 1 Needle needle NN cord-010092-uftc8inx 2265 2 - - HYPH cord-010092-uftc8inx 2265 3 related relate VBN cord-010092-uftc8inx 2265 4 DAE DAE NNP cord-010092-uftc8inx 2265 5 included include VBD cord-010092-uftc8inx 2265 6 98.3 98.3 CD cord-010092-uftc8inx 2265 7 % % NN cord-010092-uftc8inx 2265 8 Grade grade NN cord-010092-uftc8inx 2265 9 1 1 CD cord-010092-uftc8inx 2265 10 , , , cord-010092-uftc8inx 2265 11 1.6 1.6 CD cord-010092-uftc8inx 2265 12 % % NN cord-010092-uftc8inx 2265 13 Grade grade NN cord-010092-uftc8inx 2265 14 2 2 CD cord-010092-uftc8inx 2265 15 , , , cord-010092-uftc8inx 2265 16 0.1 0.1 CD cord-010092-uftc8inx 2265 17 % % NN cord-010092-uftc8inx 2265 18 Grade grade NN cord-010092-uftc8inx 2265 19 3 3 CD cord-010092-uftc8inx 2265 20 , , , cord-010092-uftc8inx 2265 21 and and CC cord-010092-uftc8inx 2265 22 no no DT cord-010092-uftc8inx 2265 23 Grade grade NN cord-010092-uftc8inx 2265 24 4 4 CD cord-010092-uftc8inx 2265 25 events event NNS cord-010092-uftc8inx 2265 26 . . . cord-010092-uftc8inx 2266 1 Of of IN cord-010092-uftc8inx 2266 2 the the DT cord-010092-uftc8inx 2266 3 six six CD cord-010092-uftc8inx 2266 4 Grade grade NN cord-010092-uftc8inx 2266 5 3 3 CD cord-010092-uftc8inx 2266 6 Needle needle NN cord-010092-uftc8inx 2266 7 - - HYPH cord-010092-uftc8inx 2266 8 related relate VBN cord-010092-uftc8inx 2266 9 DAE DAE NNP cord-010092-uftc8inx 2266 10 , , , cord-010092-uftc8inx 2266 11 4 4 CD cord-010092-uftc8inx 2266 12 were be VBD cord-010092-uftc8inx 2266 13 nerve nerve NN cord-010092-uftc8inx 2266 14 irritations irritation NNS cord-010092-uftc8inx 2266 15 lasting last VBG cord-010092-uftc8inx 2266 16 > > XX cord-010092-uftc8inx 2266 17 6 6 CD cord-010092-uftc8inx 2266 18 months month NNS cord-010092-uftc8inx 2266 19 , , , cord-010092-uftc8inx 2266 20 and and CC cord-010092-uftc8inx 2266 21 2 2 CD cord-010092-uftc8inx 2266 22 were be VBD cord-010092-uftc8inx 2266 23 DVTs dvt NNS cord-010092-uftc8inx 2266 24 requiring require VBG cord-010092-uftc8inx 2266 25 hospitalization hospitalization NN cord-010092-uftc8inx 2266 26 . . . cord-010092-uftc8inx 2267 1 Summary Summary NNP cord-010092-uftc8inx 2267 2 / / SYM cord-010092-uftc8inx 2267 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 2267 4 : : : cord-010092-uftc8inx 2268 1 The the DT cord-010092-uftc8inx 2268 2 SGT SGT NNP cord-010092-uftc8inx 2268 3 provided provide VBD cord-010092-uftc8inx 2268 4 consistent consistent JJ cord-010092-uftc8inx 2268 5 assignment assignment NN cord-010092-uftc8inx 2268 6 of of IN cord-010092-uftc8inx 2268 7 severity severity NN cord-010092-uftc8inx 2268 8 for for IN cord-010092-uftc8inx 2268 9 the the DT cord-010092-uftc8inx 2268 10 majority majority NN cord-010092-uftc8inx 2268 11 of of IN cord-010092-uftc8inx 2268 12 DAE DAE NNP cord-010092-uftc8inx 2268 13 , , , cord-010092-uftc8inx 2268 14 based base VBN cord-010092-uftc8inx 2268 15 on on IN cord-010092-uftc8inx 2268 16 Outside Outside NNP cord-010092-uftc8inx 2268 17 Medical Medical NNP cord-010092-uftc8inx 2268 18 Care Care NNP cord-010092-uftc8inx 2268 19 and and CC cord-010092-uftc8inx 2268 20 Specific specific JJ cord-010092-uftc8inx 2268 21 Key key JJ cord-010092-uftc8inx 2268 22 search search NN cord-010092-uftc8inx 2268 23 terms term NNS cord-010092-uftc8inx 2268 24 . . . cord-010092-uftc8inx 2269 1 Assignment assignment NN cord-010092-uftc8inx 2269 2 of of IN cord-010092-uftc8inx 2269 3 severity severity NN cord-010092-uftc8inx 2269 4 based base VBN cord-010092-uftc8inx 2269 5 on on IN cord-010092-uftc8inx 2269 6 Impact Impact NNP cord-010092-uftc8inx 2269 7 on on IN cord-010092-uftc8inx 2269 8 Activities Activities NNPS cord-010092-uftc8inx 2269 9 of of IN cord-010092-uftc8inx 2269 10 Daily Daily NNP cord-010092-uftc8inx 2269 11 Living Living NNP cord-010092-uftc8inx 2269 12 or or CC cord-010092-uftc8inx 2269 13 on on IN cord-010092-uftc8inx 2269 14 Duration duration NN cord-010092-uftc8inx 2269 15 of of IN cord-010092-uftc8inx 2269 16 injury injury NN cord-010092-uftc8inx 2269 17 / / SYM cord-010092-uftc8inx 2269 18 condition condition NN cord-010092-uftc8inx 2269 19 requires require VBZ cord-010092-uftc8inx 2269 20 tracking tracking NN cord-010092-uftc8inx 2269 21 over over IN cord-010092-uftc8inx 2269 22 time time NN cord-010092-uftc8inx 2269 23 making make VBG cord-010092-uftc8inx 2269 24 such such JJ cord-010092-uftc8inx 2269 25 assignments assignment NNS cord-010092-uftc8inx 2269 26 more more RBR cord-010092-uftc8inx 2269 27 difficult difficult JJ cord-010092-uftc8inx 2269 28 ; ; : cord-010092-uftc8inx 2269 29 modification modification NN cord-010092-uftc8inx 2269 30 of of IN cord-010092-uftc8inx 2269 31 our -PRON- PRP$ cord-010092-uftc8inx 2269 32 DAE DAE NNP cord-010092-uftc8inx 2269 33 tracking tracking NN cord-010092-uftc8inx 2269 34 database database NN cord-010092-uftc8inx 2269 35 and and CC cord-010092-uftc8inx 2269 36 claims claim NNS cord-010092-uftc8inx 2269 37 database database NN cord-010092-uftc8inx 2269 38 to to TO cord-010092-uftc8inx 2269 39 capture capture VB cord-010092-uftc8inx 2269 40 ADL ADL NNP cord-010092-uftc8inx 2269 41 and and CC cord-010092-uftc8inx 2269 42 Duration duration NN cord-010092-uftc8inx 2269 43 should should MD cord-010092-uftc8inx 2269 44 improve improve VB cord-010092-uftc8inx 2269 45 severity severity NN cord-010092-uftc8inx 2269 46 assignment assignment NN cord-010092-uftc8inx 2269 47 for for IN cord-010092-uftc8inx 2269 48 such such JJ cord-010092-uftc8inx 2269 49 cases case NNS cord-010092-uftc8inx 2269 50 . . . cord-010092-uftc8inx 2270 1 Background background NN cord-010092-uftc8inx 2270 2 : : : cord-010092-uftc8inx 2271 1 The the DT cord-010092-uftc8inx 2271 2 International International NNP cord-010092-uftc8inx 2271 3 Haemovigilance Haemovigilance NNP cord-010092-uftc8inx 2271 4 Network Network NNP cord-010092-uftc8inx 2271 5 ( ( -LRB- cord-010092-uftc8inx 2271 6 IHN IHN NNP cord-010092-uftc8inx 2271 7 ) ) -RRB- cord-010092-uftc8inx 2271 8 has have VBZ cord-010092-uftc8inx 2271 9 collected collect VBN cord-010092-uftc8inx 2271 10 aggregate aggregate JJ cord-010092-uftc8inx 2271 11 data datum NNS cord-010092-uftc8inx 2271 12 on on IN cord-010092-uftc8inx 2271 13 complications complication NNS cord-010092-uftc8inx 2271 14 of of IN cord-010092-uftc8inx 2271 15 whole whole JJ cord-010092-uftc8inx 2271 16 blood blood NN cord-010092-uftc8inx 2271 17 and and CC cord-010092-uftc8inx 2271 18 apheresis apheresis NN cord-010092-uftc8inx 2271 19 donations donation NNS cord-010092-uftc8inx 2271 20 from from IN cord-010092-uftc8inx 2271 21 member member NN cord-010092-uftc8inx 2271 22 national national NNP cord-010092-uftc8inx 2271 23 haemovigilance haemovigilance NNP cord-010092-uftc8inx 2271 24 systems system NNS cord-010092-uftc8inx 2271 25 ( ( -LRB- cord-010092-uftc8inx 2271 26 HVS HVS NNP cord-010092-uftc8inx 2271 27 ) ) -RRB- cord-010092-uftc8inx 2271 28 since since IN cord-010092-uftc8inx 2271 29 2006 2006 CD cord-010092-uftc8inx 2271 30 . . . cord-010092-uftc8inx 2272 1 Aims aim VBZ cord-010092-uftc8inx 2272 2 : : : cord-010092-uftc8inx 2273 1 We -PRON- PRP cord-010092-uftc8inx 2273 2 analysed analyse VBD cord-010092-uftc8inx 2273 3 the the DT cord-010092-uftc8inx 2273 4 data datum NNS cord-010092-uftc8inx 2273 5 collected collect VBN cord-010092-uftc8inx 2273 6 in in IN cord-010092-uftc8inx 2273 7 2006 2006 CD cord-010092-uftc8inx 2273 8 - - SYM cord-010092-uftc8inx 2273 9 2016 2016 CD cord-010092-uftc8inx 2273 10 in in IN cord-010092-uftc8inx 2273 11 order order NN cord-010092-uftc8inx 2273 12 to to TO cord-010092-uftc8inx 2273 13 learn learn VB cord-010092-uftc8inx 2273 14 from from IN cord-010092-uftc8inx 2273 15 the the DT cord-010092-uftc8inx 2273 16 data datum NNS cord-010092-uftc8inx 2273 17 and and CC cord-010092-uftc8inx 2273 18 consider consider VB cord-010092-uftc8inx 2273 19 future future JJ cord-010092-uftc8inx 2273 20 improvement improvement NN cord-010092-uftc8inx 2273 21 of of IN cord-010092-uftc8inx 2273 22 data datum NNS cord-010092-uftc8inx 2273 23 collection collection NN cord-010092-uftc8inx 2273 24 . . . cord-010092-uftc8inx 2274 1 Methods method NNS cord-010092-uftc8inx 2274 2 : : : cord-010092-uftc8inx 2275 1 National National NNP cord-010092-uftc8inx 2275 2 HVS HVS NNP cord-010092-uftc8inx 2275 3 entered enter VBD cord-010092-uftc8inx 2275 4 annual annual JJ cord-010092-uftc8inx 2275 5 data datum NNS cord-010092-uftc8inx 2275 6 on on IN cord-010092-uftc8inx 2275 7 donor donor NN cord-010092-uftc8inx 2275 8 complications complication NNS cord-010092-uftc8inx 2275 9 in in IN cord-010092-uftc8inx 2275 10 the the DT cord-010092-uftc8inx 2275 11 passwordprotected passwordprotected JJ cord-010092-uftc8inx 2275 12 " " `` cord-010092-uftc8inx 2275 13 ISTARE ISTARE NNP cord-010092-uftc8inx 2275 14 " " '' cord-010092-uftc8inx 2275 15 ( ( -LRB- cord-010092-uftc8inx 2275 16 International International NNP cord-010092-uftc8inx 2275 17 Surveillance Surveillance NNP cord-010092-uftc8inx 2275 18 of of IN cord-010092-uftc8inx 2275 19 Transfusion Transfusion NNP cord-010092-uftc8inx 2275 20 Adverse Adverse NNP cord-010092-uftc8inx 2275 21 Reactions Reactions NNPS cord-010092-uftc8inx 2275 22 and and CC cord-010092-uftc8inx 2275 23 Events event NNS cord-010092-uftc8inx 2275 24 ) ) -RRB- cord-010092-uftc8inx 2275 25 online online JJ cord-010092-uftc8inx 2275 26 database database NN cord-010092-uftc8inx 2275 27 . . . cord-010092-uftc8inx 2276 1 From from IN cord-010092-uftc8inx 2276 2 2008 2008 CD cord-010092-uftc8inx 2276 3 the the DT cord-010092-uftc8inx 2276 4 donor donor NN cord-010092-uftc8inx 2276 5 complication complication NN cord-010092-uftc8inx 2276 6 spreadsheet spreadsheet NN cord-010092-uftc8inx 2276 7 allowed allow VBN cord-010092-uftc8inx 2276 8 entry entry NN cord-010092-uftc8inx 2276 9 of of IN cord-010092-uftc8inx 2276 10 separate separate JJ cord-010092-uftc8inx 2276 11 data datum NNS cord-010092-uftc8inx 2276 12 for for IN cord-010092-uftc8inx 2276 13 whole whole JJ cord-010092-uftc8inx 2276 14 blood blood NN cord-010092-uftc8inx 2276 15 donation donation NN cord-010092-uftc8inx 2276 16 ( ( -LRB- cord-010092-uftc8inx 2276 17 WBD WBD NNP cord-010092-uftc8inx 2276 18 ) ) -RRB- cord-010092-uftc8inx 2276 19 and and CC cord-010092-uftc8inx 2276 20 apheresis apheresis NN cord-010092-uftc8inx 2276 21 , , , cord-010092-uftc8inx 2276 22 but but CC cord-010092-uftc8inx 2276 23 also also RB cord-010092-uftc8inx 2276 24 provided provide VBD cord-010092-uftc8inx 2276 25 an an DT cord-010092-uftc8inx 2276 26 option option NN cord-010092-uftc8inx 2276 27 for for IN cord-010092-uftc8inx 2276 28 entering enter VBG cord-010092-uftc8inx 2276 29 data datum NNS cord-010092-uftc8inx 2276 30 for for IN cord-010092-uftc8inx 2276 31 all all DT cord-010092-uftc8inx 2276 32 donation donation NN cord-010092-uftc8inx 2276 33 types type NNS cord-010092-uftc8inx 2276 34 . . . cord-010092-uftc8inx 2277 1 Annual annual JJ cord-010092-uftc8inx 2277 2 numbers number NNS cord-010092-uftc8inx 2277 3 of of IN cord-010092-uftc8inx 2277 4 whole whole JJ cord-010092-uftc8inx 2277 5 blood blood NN cord-010092-uftc8inx 2277 6 and and CC cord-010092-uftc8inx 2277 7 apheresis apheresis NN cord-010092-uftc8inx 2277 8 donations donation NNS cord-010092-uftc8inx 2277 9 were be VBD cord-010092-uftc8inx 2277 10 also also RB cord-010092-uftc8inx 2277 11 collected collect VBN cord-010092-uftc8inx 2277 12 . . . cord-010092-uftc8inx 2278 1 The the DT cord-010092-uftc8inx 2278 2 harmonised harmonised JJ cord-010092-uftc8inx 2278 3 international international JJ cord-010092-uftc8inx 2278 4 standard standard JJ cord-010092-uftc8inx 2278 5 definitions definition NNS cord-010092-uftc8inx 2278 6 were be VBD cord-010092-uftc8inx 2278 7 implemented implement VBN cord-010092-uftc8inx 2278 8 in in IN cord-010092-uftc8inx 2278 9 2015 2015 CD cord-010092-uftc8inx 2278 10 . . . cord-010092-uftc8inx 2279 1 Reactions reaction NNS cord-010092-uftc8inx 2279 2 were be VBD cord-010092-uftc8inx 2279 3 captured capture VBN cord-010092-uftc8inx 2279 4 according accord VBG cord-010092-uftc8inx 2279 5 to to IN cord-010092-uftc8inx 2279 6 severity severity NN cord-010092-uftc8inx 2279 7 level level NN cord-010092-uftc8inx 2279 8 ( ( -LRB- cord-010092-uftc8inx 2279 9 mild mild JJ cord-010092-uftc8inx 2279 10 , , , cord-010092-uftc8inx 2279 11 moderate moderate JJ cord-010092-uftc8inx 2279 12 , , , cord-010092-uftc8inx 2279 13 severe severe JJ cord-010092-uftc8inx 2279 14 ) ) -RRB- cord-010092-uftc8inx 2279 15 but but CC cord-010092-uftc8inx 2279 16 without without IN cord-010092-uftc8inx 2279 17 distinction distinction NN cord-010092-uftc8inx 2279 18 between between IN cord-010092-uftc8inx 2279 19 donor donor NN cord-010092-uftc8inx 2279 20 sex sex NN cord-010092-uftc8inx 2279 21 or or CC cord-010092-uftc8inx 2279 22 first first JJ cord-010092-uftc8inx 2279 23 time time NN cord-010092-uftc8inx 2279 24 vs vs IN cord-010092-uftc8inx 2279 25 repeat repeat NN cord-010092-uftc8inx 2279 26 donation donation NN cord-010092-uftc8inx 2279 27 . . . cord-010092-uftc8inx 2280 1 Extracted extract VBN cord-010092-uftc8inx 2280 2 data datum NNS cord-010092-uftc8inx 2280 3 were be VBD cord-010092-uftc8inx 2280 4 used use VBN cord-010092-uftc8inx 2280 5 to to TO cord-010092-uftc8inx 2280 6 calculate calculate VB cord-010092-uftc8inx 2280 7 national national JJ cord-010092-uftc8inx 2280 8 and and CC cord-010092-uftc8inx 2280 9 aggregate aggregate JJ cord-010092-uftc8inx 2280 10 donor donor NN cord-010092-uftc8inx 2280 11 complication complication NN cord-010092-uftc8inx 2280 12 rates rate NNS cord-010092-uftc8inx 2280 13 ( ( -LRB- cord-010092-uftc8inx 2280 14 generally generally RB cord-010092-uftc8inx 2280 15 per per IN cord-010092-uftc8inx 2280 16 1000 1000 CD cord-010092-uftc8inx 2280 17 donations donation NNS cord-010092-uftc8inx 2280 18 ) ) -RRB- cord-010092-uftc8inx 2280 19 . . . cord-010092-uftc8inx 2281 1 Results result NNS cord-010092-uftc8inx 2281 2 : : : cord-010092-uftc8inx 2282 1 Twenty twenty CD cord-010092-uftc8inx 2282 2 - - HYPH cord-010092-uftc8inx 2282 3 four four CD cord-010092-uftc8inx 2282 4 HVS HVS NNP cord-010092-uftc8inx 2282 5 provided provide VBD cord-010092-uftc8inx 2282 6 figures figure NNS cord-010092-uftc8inx 2282 7 for for IN cord-010092-uftc8inx 2282 8 donations donation NNS cord-010092-uftc8inx 2282 9 and and CC cord-010092-uftc8inx 2282 10 donor donor NN cord-010092-uftc8inx 2282 11 complications complication NNS cord-010092-uftc8inx 2282 12 for for IN cord-010092-uftc8inx 2282 13 one one CD cord-010092-uftc8inx 2282 14 or or CC cord-010092-uftc8inx 2282 15 more more JJR cord-010092-uftc8inx 2282 16 years year NNS cord-010092-uftc8inx 2282 17 ( ( -LRB- cord-010092-uftc8inx 2282 18 median median JJ cord-010092-uftc8inx 2282 19 years year NNS cord-010092-uftc8inx 2282 20 per per IN cord-010092-uftc8inx 2282 21 country country NN cord-010092-uftc8inx 2282 22 was be VBD cord-010092-uftc8inx 2282 23 7 7 CD cord-010092-uftc8inx 2282 24 , , , cord-010092-uftc8inx 2282 25 IQR IQR NNP cord-010092-uftc8inx 2282 26 2 2 CD cord-010092-uftc8inx 2282 27 - - SYM cord-010092-uftc8inx 2282 28 8 8 CD cord-010092-uftc8inx 2282 29 ) ) -RRB- cord-010092-uftc8inx 2282 30 . . . cord-010092-uftc8inx 2283 1 The the DT cord-010092-uftc8inx 2283 2 total total JJ cord-010092-uftc8inx 2283 3 number number NN cord-010092-uftc8inx 2283 4 of of IN cord-010092-uftc8inx 2283 5 country country NN cord-010092-uftc8inx 2283 6 years year NNS cord-010092-uftc8inx 2283 7 ( ( -LRB- cord-010092-uftc8inx 2283 8 CY CY NNP cord-010092-uftc8inx 2283 9 ) ) -RRB- cord-010092-uftc8inx 2283 10 was be VBD cord-010092-uftc8inx 2283 11 138 138 CD cord-010092-uftc8inx 2283 12 , , , cord-010092-uftc8inx 2283 13 covering cover VBG cord-010092-uftc8inx 2283 14 155 155 CD cord-010092-uftc8inx 2283 15 million million CD cord-010092-uftc8inx 2283 16 donations donation NNS cord-010092-uftc8inx 2283 17 . . . cord-010092-uftc8inx 2284 1 The the DT cord-010092-uftc8inx 2284 2 overall overall JJ cord-010092-uftc8inx 2284 3 complication complication NN cord-010092-uftc8inx 2284 4 rate rate NN cord-010092-uftc8inx 2284 5 was be VBD cord-010092-uftc8inx 2284 6 6.3/1000 6.3/1000 CD cord-010092-uftc8inx 2284 7 donations donation NNS cord-010092-uftc8inx 2284 8 and and CC cord-010092-uftc8inx 2284 9 the the DT cord-010092-uftc8inx 2284 10 median median JJ cord-010092-uftc8inx 2284 11 country country NN cord-010092-uftc8inx 2284 12 rate rate NN cord-010092-uftc8inx 2284 13 was be VBD cord-010092-uftc8inx 2284 14 3.2 3.2 CD cord-010092-uftc8inx 2284 15 complications/1000 complications/1000 NFP cord-010092-uftc8inx 2284 16 donations donation NNS cord-010092-uftc8inx 2285 1 ( ( -LRB- cord-010092-uftc8inx 2285 2 IQR IQR NNP cord-010092-uftc8inx 2285 3 1.1 1.1 CD cord-010092-uftc8inx 2285 4 - - HYPH cord-010092-uftc8inx 2285 5 10.1 10.1 CD cord-010092-uftc8inx 2285 6 ) ) -RRB- cord-010092-uftc8inx 2285 7 . . . cord-010092-uftc8inx 2286 1 Rates rate NNS cord-010092-uftc8inx 2286 2 were be VBD cord-010092-uftc8inx 2286 3 generally generally RB cord-010092-uftc8inx 2286 4 consistent consistent JJ cord-010092-uftc8inx 2286 5 within within IN cord-010092-uftc8inx 2286 6 a a DT cord-010092-uftc8inx 2286 7 HVS HVS NNP cord-010092-uftc8inx 2286 8 from from IN cord-010092-uftc8inx 2286 9 year year NN cord-010092-uftc8inx 2286 10 to to IN cord-010092-uftc8inx 2286 11 year year NN cord-010092-uftc8inx 2286 12 but but CC cord-010092-uftc8inx 2286 13 showed show VBD cord-010092-uftc8inx 2286 14 considerable considerable JJ cord-010092-uftc8inx 2286 15 variation variation NN cord-010092-uftc8inx 2286 16 between between IN cord-010092-uftc8inx 2286 17 HVS HVS NNP cord-010092-uftc8inx 2286 18 ; ; : cord-010092-uftc8inx 2286 19 this this DT cord-010092-uftc8inx 2286 20 was be VBD cord-010092-uftc8inx 2286 21 also also RB cord-010092-uftc8inx 2286 22 the the DT cord-010092-uftc8inx 2286 23 case case NN cord-010092-uftc8inx 2286 24 for for IN cord-010092-uftc8inx 2286 25 reactions reaction NNS cord-010092-uftc8inx 2286 26 classed class VBN cord-010092-uftc8inx 2286 27 as as IN cord-010092-uftc8inx 2286 28 severe severe JJ cord-010092-uftc8inx 2286 29 . . . cord-010092-uftc8inx 2287 1 Not not RB cord-010092-uftc8inx 2287 2 all all DT cord-010092-uftc8inx 2287 3 countries country NNS cord-010092-uftc8inx 2287 4 differentiated differentiate VBN cord-010092-uftc8inx 2287 5 between between IN cord-010092-uftc8inx 2287 6 mild mild JJ cord-010092-uftc8inx 2287 7 and and CC cord-010092-uftc8inx 2287 8 moderate moderate JJ cord-010092-uftc8inx 2287 9 reactions reaction NNS cord-010092-uftc8inx 2287 10 and and CC cord-010092-uftc8inx 2287 11 some some DT cord-010092-uftc8inx 2287 12 reported report VBD cord-010092-uftc8inx 2287 13 all all DT cord-010092-uftc8inx 2287 14 reactions reaction NNS cord-010092-uftc8inx 2287 15 under under IN cord-010092-uftc8inx 2287 16 a a DT cord-010092-uftc8inx 2287 17 single single JJ cord-010092-uftc8inx 2287 18 severity severity NN cord-010092-uftc8inx 2287 19 level level NN cord-010092-uftc8inx 2287 20 . . . cord-010092-uftc8inx 2288 1 Vasovagal vasovagal JJ cord-010092-uftc8inx 2288 2 reactions reaction NNS cord-010092-uftc8inx 2288 3 were be VBD cord-010092-uftc8inx 2288 4 the the DT cord-010092-uftc8inx 2288 5 most most RBS cord-010092-uftc8inx 2288 6 commonly commonly RB cord-010092-uftc8inx 2288 7 reported report VBN cord-010092-uftc8inx 2288 8 complication complication NN cord-010092-uftc8inx 2288 9 : : : cord-010092-uftc8inx 2288 10 overall overall JJ cord-010092-uftc8inx 2288 11 4.6/ 4.6/ CD cord-010092-uftc8inx 2288 12 1000 1000 CD cord-010092-uftc8inx 2288 13 donations donation NNS cord-010092-uftc8inx 2288 14 , , , cord-010092-uftc8inx 2288 15 median median JJ cord-010092-uftc8inx 2288 16 country country NN cord-010092-uftc8inx 2288 17 rate rate NN cord-010092-uftc8inx 2288 18 3.1/1000 3.1/1000 CD cord-010092-uftc8inx 2288 19 donations donation NNS cord-010092-uftc8inx 2288 20 ( ( -LRB- cord-010092-uftc8inx 2288 21 IQR IQR NNP cord-010092-uftc8inx 2288 22 0.6 0.6 CD cord-010092-uftc8inx 2288 23 - - SYM cord-010092-uftc8inx 2288 24 7.7 7.7 CD cord-010092-uftc8inx 2288 25 ) ) -RRB- cord-010092-uftc8inx 2288 26 . . . cord-010092-uftc8inx 2289 1 Rare rare JJ cord-010092-uftc8inx 2289 2 and and CC cord-010092-uftc8inx 2289 3 apheresis apheresis NN cord-010092-uftc8inx 2289 4 - - HYPH cord-010092-uftc8inx 2289 5 related relate VBN cord-010092-uftc8inx 2289 6 types type NNS cord-010092-uftc8inx 2289 7 of of IN cord-010092-uftc8inx 2289 8 complications complication NNS cord-010092-uftc8inx 2289 9 such such JJ cord-010092-uftc8inx 2289 10 as as IN cord-010092-uftc8inx 2289 11 generalized generalize VBN cord-010092-uftc8inx 2289 12 allergic allergic JJ cord-010092-uftc8inx 2289 13 reaction reaction NN cord-010092-uftc8inx 2289 14 ( ( -LRB- cord-010092-uftc8inx 2289 15 0.10 0.10 CD cord-010092-uftc8inx 2289 16 per per IN cord-010092-uftc8inx 2289 17 100,000 100,000 CD cord-010092-uftc8inx 2289 18 , , , cord-010092-uftc8inx 2289 19 40 40 CD cord-010092-uftc8inx 2289 20 CY CY NNP cord-010092-uftc8inx 2289 21 ) ) -RRB- cord-010092-uftc8inx 2289 22 , , , cord-010092-uftc8inx 2289 23 and and CC cord-010092-uftc8inx 2289 24 major major JJ cord-010092-uftc8inx 2289 25 blood blood NN cord-010092-uftc8inx 2289 26 vessel vessel NN cord-010092-uftc8inx 2289 27 injury injury NN cord-010092-uftc8inx 2289 28 ( ( -LRB- cord-010092-uftc8inx 2289 29 category category NN cord-010092-uftc8inx 2289 30 available available JJ cord-010092-uftc8inx 2289 31 since since IN cord-010092-uftc8inx 2289 32 2015 2015 CD cord-010092-uftc8inx 2289 33 ; ; : cord-010092-uftc8inx 2289 34 overall overall JJ cord-010092-uftc8inx 2289 35 0.12 0.12 CD cord-010092-uftc8inx 2289 36 per per IN cord-010092-uftc8inx 2289 37 100,000 100,000 CD cord-010092-uftc8inx 2289 38 , , , cord-010092-uftc8inx 2289 39 6 6 CD cord-010092-uftc8inx 2289 40 CY CY NNP cord-010092-uftc8inx 2289 41 ) ) -RRB- cord-010092-uftc8inx 2289 42 were be VBD cord-010092-uftc8inx 2289 43 only only RB cord-010092-uftc8inx 2289 44 reported report VBN cord-010092-uftc8inx 2289 45 occasionally occasionally RB cord-010092-uftc8inx 2289 46 . . . cord-010092-uftc8inx 2290 1 Eighteen eighteen CD cord-010092-uftc8inx 2290 2 of of IN cord-010092-uftc8inx 2290 3 the the DT cord-010092-uftc8inx 2290 4 HVS HVS NNP cord-010092-uftc8inx 2290 5 provided provide VBD cord-010092-uftc8inx 2290 6 separate separate JJ cord-010092-uftc8inx 2290 7 data datum NNS cord-010092-uftc8inx 2290 8 for for IN cord-010092-uftc8inx 2290 9 complications complication NNS cord-010092-uftc8inx 2290 10 of of IN cord-010092-uftc8inx 2290 11 whole whole JJ cord-010092-uftc8inx 2290 12 blood blood NN cord-010092-uftc8inx 2290 13 and and CC cord-010092-uftc8inx 2290 14 apheresis apheresis NN cord-010092-uftc8inx 2290 15 donations donation NNS cord-010092-uftc8inx 2290 16 in in IN cord-010092-uftc8inx 2290 17 one one CD cord-010092-uftc8inx 2290 18 or or CC cord-010092-uftc8inx 2290 19 more more JJR cord-010092-uftc8inx 2290 20 years year NNS cord-010092-uftc8inx 2290 21 ( ( -LRB- cord-010092-uftc8inx 2290 22 total total JJ cord-010092-uftc8inx 2290 23 89 89 CD cord-010092-uftc8inx 2290 24 CY CY NNP cord-010092-uftc8inx 2290 25 , , , cord-010092-uftc8inx 2290 26 101.6 101.6 CD cord-010092-uftc8inx 2290 27 million million CD cord-010092-uftc8inx 2290 28 WBD WBD NNP cord-010092-uftc8inx 2290 29 and and CC cord-010092-uftc8inx 2290 30 26.3 26.3 CD cord-010092-uftc8inx 2290 31 million million CD cord-010092-uftc8inx 2290 32 aphereses apherese NNS cord-010092-uftc8inx 2290 33 , , , cord-010092-uftc8inx 2290 34 total total JJ cord-010092-uftc8inx 2290 35 128 128 CD cord-010092-uftc8inx 2290 36 million million CD cord-010092-uftc8inx 2290 37 donations donation NNS cord-010092-uftc8inx 2290 38 ) ) -RRB- cord-010092-uftc8inx 2290 39 . . . cord-010092-uftc8inx 2291 1 For for IN cord-010092-uftc8inx 2291 2 these these DT cord-010092-uftc8inx 2291 3 HVS HVS NNP cord-010092-uftc8inx 2291 4 the the DT cord-010092-uftc8inx 2291 5 median median JJ cord-010092-uftc8inx 2291 6 rate rate NN cord-010092-uftc8inx 2291 7 of of IN cord-010092-uftc8inx 2291 8 vasovagal vasovagal JJ cord-010092-uftc8inx 2291 9 reactions reaction NNS cord-010092-uftc8inx 2291 10 was be VBD cord-010092-uftc8inx 2291 11 3.4/1000 3.4/1000 CD cord-010092-uftc8inx 2291 12 WBD WBD NNP cord-010092-uftc8inx 2291 13 ( ( -LRB- cord-010092-uftc8inx 2291 14 IQR IQR NNP cord-010092-uftc8inx 2291 15 1.0 1.0 CD cord-010092-uftc8inx 2291 16 - - HYPH cord-010092-uftc8inx 2291 17 9.1 9.1 CD cord-010092-uftc8inx 2291 18 ) ) -RRB- cord-010092-uftc8inx 2291 19 and and CC cord-010092-uftc8inx 2291 20 1.5/1000 1.5/1000 CD cord-010092-uftc8inx 2291 21 apheresis apheresis NN cord-010092-uftc8inx 2291 22 procedures procedure NNS cord-010092-uftc8inx 2291 23 ( ( -LRB- cord-010092-uftc8inx 2291 24 1.0 1.0 CD cord-010092-uftc8inx 2291 25 - - SYM cord-010092-uftc8inx 2291 26 4.2 4.2 CD cord-010092-uftc8inx 2291 27 ) ) -RRB- cord-010092-uftc8inx 2291 28 . . . cord-010092-uftc8inx 2292 1 Reported report VBN cord-010092-uftc8inx 2292 2 haematoma haematoma NN cord-010092-uftc8inx 2292 3 rates rate NNS cord-010092-uftc8inx 2292 4 were be VBD cord-010092-uftc8inx 2292 5 higher high JJR cord-010092-uftc8inx 2292 6 for for IN cord-010092-uftc8inx 2292 7 apheresis apheresis NN cord-010092-uftc8inx 2292 8 than than IN cord-010092-uftc8inx 2292 9 for for IN cord-010092-uftc8inx 2292 10 WBD WBD NNP cord-010092-uftc8inx 2292 11 : : : cord-010092-uftc8inx 2293 1 the the DT cord-010092-uftc8inx 2293 2 median median NN cord-010092-uftc8inx 2293 3 per per IN cord-010092-uftc8inx 2293 4 HVS HVS NNP cord-010092-uftc8inx 2293 5 was be VBD cord-010092-uftc8inx 2293 6 0.39/1000 0.39/1000 CD cord-010092-uftc8inx 2293 7 WBD WBD NNP cord-010092-uftc8inx 2293 8 ( ( -LRB- cord-010092-uftc8inx 2293 9 IQR IQR NNP cord-010092-uftc8inx 2293 10 0.31 0.31 CD cord-010092-uftc8inx 2293 11 - - SYM cord-010092-uftc8inx 2293 12 1.2 1.2 CD cord-010092-uftc8inx 2293 13 ) ) -RRB- cord-010092-uftc8inx 2293 14 vs vs IN cord-010092-uftc8inx 2293 15 4.2/1000 4.2/1000 CD cord-010092-uftc8inx 2293 16 aphereses apherese NNS cord-010092-uftc8inx 2293 17 ( ( -LRB- cord-010092-uftc8inx 2293 18 0.69 0.69 CD cord-010092-uftc8inx 2293 19 - - SYM cord-010092-uftc8inx 2293 20 5.6 5.6 CD cord-010092-uftc8inx 2293 21 ) ) -RRB- cord-010092-uftc8inx 2293 22 ; ; : cord-010092-uftc8inx 2293 23 rates rate NNS cord-010092-uftc8inx 2293 24 of of IN cord-010092-uftc8inx 2293 25 arm arm NN cord-010092-uftc8inx 2293 26 pain pain NN cord-010092-uftc8inx 2293 27 and/or and/or CC cord-010092-uftc8inx 2293 28 nerve nerve NN cord-010092-uftc8inx 2293 29 injury injury NN cord-010092-uftc8inx 2293 30 ( ( -LRB- cord-010092-uftc8inx 2293 31 not not RB cord-010092-uftc8inx 2293 32 separated separate VBN cord-010092-uftc8inx 2293 33 in in IN cord-010092-uftc8inx 2293 34 2006 2006 CD cord-010092-uftc8inx 2293 35 - - SYM cord-010092-uftc8inx 2293 36 2013 2013 CD cord-010092-uftc8inx 2293 37 ) ) -RRB- cord-010092-uftc8inx 2293 38 also also RB cord-010092-uftc8inx 2293 39 tended tend VBD cord-010092-uftc8inx 2293 40 to to TO cord-010092-uftc8inx 2293 41 be be VB cord-010092-uftc8inx 2293 42 higher high JJR cord-010092-uftc8inx 2293 43 : : : cord-010092-uftc8inx 2293 44 median median NN cord-010092-uftc8inx 2293 45 0.09/1000 0.09/1000 CD cord-010092-uftc8inx 2293 46 with with IN cord-010092-uftc8inx 2293 47 WBD WBD NNP cord-010092-uftc8inx 2293 48 , , , cord-010092-uftc8inx 2293 49 IQR IQR NNP cord-010092-uftc8inx 2293 50 0.03 0.03 CD cord-010092-uftc8inx 2293 51 - - SYM cord-010092-uftc8inx 2293 52 0.34 0.34 CD cord-010092-uftc8inx 2293 53 , , , cord-010092-uftc8inx 2293 54 vs vs IN cord-010092-uftc8inx 2293 55 0.39/1000 0.39/1000 CD cord-010092-uftc8inx 2293 56 with with IN cord-010092-uftc8inx 2293 57 apheresis apheresis NN cord-010092-uftc8inx 2293 58 , , , cord-010092-uftc8inx 2293 59 0.05 0.05 CD cord-010092-uftc8inx 2293 60 - - SYM cord-010092-uftc8inx 2293 61 0.57 0.57 CD cord-010092-uftc8inx 2293 62 . . . cord-010092-uftc8inx 2294 1 Summary Summary NNP cord-010092-uftc8inx 2294 2 / / SYM cord-010092-uftc8inx 2294 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 2294 4 : : : cord-010092-uftc8inx 2295 1 International international JJ cord-010092-uftc8inx 2295 2 reporting reporting NN cord-010092-uftc8inx 2295 3 allows allow VBZ cord-010092-uftc8inx 2295 4 HVS HVS NNP cord-010092-uftc8inx 2295 5 to to TO cord-010092-uftc8inx 2295 6 study study VB cord-010092-uftc8inx 2295 7 rates rate NNS cord-010092-uftc8inx 2295 8 of of IN cord-010092-uftc8inx 2295 9 blood blood NN cord-010092-uftc8inx 2295 10 donation donation NN cord-010092-uftc8inx 2295 11 complications complication NNS cord-010092-uftc8inx 2295 12 , , , cord-010092-uftc8inx 2295 13 to to TO cord-010092-uftc8inx 2295 14 distinguish distinguish VB cord-010092-uftc8inx 2295 15 between between IN cord-010092-uftc8inx 2295 16 WBD WBD NNP cord-010092-uftc8inx 2295 17 and and CC cord-010092-uftc8inx 2295 18 apheresis apheresis NN cord-010092-uftc8inx 2295 19 complication complication NN cord-010092-uftc8inx 2295 20 rates rate NNS cord-010092-uftc8inx 2295 21 and and CC cord-010092-uftc8inx 2295 22 capture capture VB cord-010092-uftc8inx 2295 23 information information NN cord-010092-uftc8inx 2295 24 about about IN cord-010092-uftc8inx 2295 25 very very RB cord-010092-uftc8inx 2295 26 rare rare JJ cord-010092-uftc8inx 2295 27 events event NNS cord-010092-uftc8inx 2295 28 . . . cord-010092-uftc8inx 2296 1 Variability variability NN cord-010092-uftc8inx 2296 2 of of IN cord-010092-uftc8inx 2296 3 reporting reporting NN cord-010092-uftc8inx 2296 4 and and CC cord-010092-uftc8inx 2296 5 of of IN cord-010092-uftc8inx 2296 6 severity severity NN cord-010092-uftc8inx 2296 7 assessment assessment NN cord-010092-uftc8inx 2296 8 between between IN cord-010092-uftc8inx 2296 9 countries country NNS cord-010092-uftc8inx 2296 10 impairs impair VBZ cord-010092-uftc8inx 2296 11 the the DT cord-010092-uftc8inx 2296 12 feasibility feasibility NN cord-010092-uftc8inx 2296 13 of of IN cord-010092-uftc8inx 2296 14 comparisons comparison NNS cord-010092-uftc8inx 2296 15 between between IN cord-010092-uftc8inx 2296 16 HVS HVS NNP cord-010092-uftc8inx 2296 17 . . . cord-010092-uftc8inx 2297 1 Work work NN cord-010092-uftc8inx 2297 2 is be VBZ cord-010092-uftc8inx 2297 3 needed need VBN cord-010092-uftc8inx 2297 4 to to TO cord-010092-uftc8inx 2297 5 improve improve VB cord-010092-uftc8inx 2297 6 harmonisation harmonisation NN cord-010092-uftc8inx 2297 7 of of IN cord-010092-uftc8inx 2297 8 classification classification NN cord-010092-uftc8inx 2297 9 of of IN cord-010092-uftc8inx 2297 10 donation donation NN cord-010092-uftc8inx 2297 11 complications complication NNS cord-010092-uftc8inx 2297 12 and and CC cord-010092-uftc8inx 2297 13 severity severity NN cord-010092-uftc8inx 2297 14 assessment assessment NN cord-010092-uftc8inx 2297 15 for for IN cord-010092-uftc8inx 2297 16 data data NN cord-010092-uftc8inx 2297 17 comparison comparison NN cord-010092-uftc8inx 2297 18 and and CC cord-010092-uftc8inx 2297 19 research research NN cord-010092-uftc8inx 2297 20 . . . cord-010092-uftc8inx 2298 1 Background background NN cord-010092-uftc8inx 2298 2 : : : cord-010092-uftc8inx 2299 1 To to TO cord-010092-uftc8inx 2299 2 prevent prevent VB cord-010092-uftc8inx 2299 3 iron iron NN cord-010092-uftc8inx 2299 4 related relate VBN cord-010092-uftc8inx 2299 5 Hb Hb NNP cord-010092-uftc8inx 2299 6 loss loss NN cord-010092-uftc8inx 2299 7 , , , cord-010092-uftc8inx 2299 8 screening screen VBG cord-010092-uftc8inx 2299 9 with with IN cord-010092-uftc8inx 2299 10 ferritin ferritin NN cord-010092-uftc8inx 2299 11 testing testing NN cord-010092-uftc8inx 2299 12 was be VBD cord-010092-uftc8inx 2299 13 implemented implement VBN cord-010092-uftc8inx 2299 14 in in IN cord-010092-uftc8inx 2299 15 Stockholm Stockholm NNP cord-010092-uftc8inx 2299 16 county county NN cord-010092-uftc8inx 2299 17 ( ( -LRB- cord-010092-uftc8inx 2299 18 approx approx NN cord-010092-uftc8inx 2299 19 . . . cord-010092-uftc8inx 2300 1 52000 52000 CD cord-010092-uftc8inx 2300 2 registered register VBN cord-010092-uftc8inx 2300 3 blood blood NN cord-010092-uftc8inx 2300 4 donors donor NNS cord-010092-uftc8inx 2300 5 ) ) -RRB- cord-010092-uftc8inx 2300 6 during during IN cord-010092-uftc8inx 2300 7 a a DT cord-010092-uftc8inx 2300 8 two two CD cord-010092-uftc8inx 2300 9 - - HYPH cord-010092-uftc8inx 2300 10 year year NN cord-010092-uftc8inx 2300 11 roll roll NN cord-010092-uftc8inx 2300 12 - - HYPH cord-010092-uftc8inx 2300 13 out out NN cord-010092-uftc8inx 2300 14 . . . cord-010092-uftc8inx 2301 1 Iron iron NN cord-010092-uftc8inx 2301 2 supplementation supplementation NN cord-010092-uftc8inx 2301 3 is be VBZ cord-010092-uftc8inx 2301 4 offered offer VBN cord-010092-uftc8inx 2301 5 to to IN cord-010092-uftc8inx 2301 6 blood blood NN cord-010092-uftc8inx 2301 7 donors donor NNS cord-010092-uftc8inx 2301 8 but but CC cord-010092-uftc8inx 2301 9 has have VBZ cord-010092-uftc8inx 2301 10 not not RB cord-010092-uftc8inx 2301 11 prevented prevent VBN cord-010092-uftc8inx 2301 12 Hb Hb NNP cord-010092-uftc8inx 2301 13 deferrals deferral NNS cord-010092-uftc8inx 2301 14 resulting result VBG cord-010092-uftc8inx 2301 15 in in IN cord-010092-uftc8inx 2301 16 8000 8000 CD cord-010092-uftc8inx 2301 17 control control NN cord-010092-uftc8inx 2301 18 visits visit NNS cord-010092-uftc8inx 2301 19 per per IN cord-010092-uftc8inx 2301 20 year year NN cord-010092-uftc8inx 2301 21 . . . cord-010092-uftc8inx 2302 1 Ferritin ferritin NN cord-010092-uftc8inx 2302 2 testing testing NN cord-010092-uftc8inx 2302 3 is be VBZ cord-010092-uftc8inx 2302 4 hypothesized hypothesize VBN cord-010092-uftc8inx 2302 5 to to TO cord-010092-uftc8inx 2302 6 increase increase VB cord-010092-uftc8inx 2302 7 iron iron NN cord-010092-uftc8inx 2302 8 compliance compliance NN cord-010092-uftc8inx 2302 9 . . . cord-010092-uftc8inx 2303 1 Aims aim VBZ cord-010092-uftc8inx 2303 2 : : : cord-010092-uftc8inx 2303 3 Implementation implementation NN cord-010092-uftc8inx 2303 4 of of IN cord-010092-uftc8inx 2303 5 ferritin ferritin NN cord-010092-uftc8inx 2303 6 testing testing NN cord-010092-uftc8inx 2303 7 for for IN cord-010092-uftc8inx 2303 8 surveillance surveillance NN cord-010092-uftc8inx 2303 9 of of IN cord-010092-uftc8inx 2303 10 iron iron NN cord-010092-uftc8inx 2303 11 levels level NNS cord-010092-uftc8inx 2303 12 for for IN cord-010092-uftc8inx 2303 13 the the DT cord-010092-uftc8inx 2303 14 entire entire JJ cord-010092-uftc8inx 2303 15 blood blood NN cord-010092-uftc8inx 2303 16 donor donor NN cord-010092-uftc8inx 2303 17 population population NN cord-010092-uftc8inx 2303 18 with with IN cord-010092-uftc8inx 2303 19 specific specific JJ cord-010092-uftc8inx 2303 20 attention attention NN cord-010092-uftc8inx 2303 21 to to IN cord-010092-uftc8inx 2303 22 new new JJ cord-010092-uftc8inx 2303 23 donors donor NNS cord-010092-uftc8inx 2303 24 , , , cord-010092-uftc8inx 2303 25 women woman NNS cord-010092-uftc8inx 2303 26 returning return VBG cord-010092-uftc8inx 2303 27 after after IN cord-010092-uftc8inx 2303 28 pregnancy pregnancy NN cord-010092-uftc8inx 2303 29 , , , cord-010092-uftc8inx 2303 30 donors donor NNS cord-010092-uftc8inx 2303 31 with with IN cord-010092-uftc8inx 2303 32 low low JJ cord-010092-uftc8inx 2303 33 Hb Hb NNP cord-010092-uftc8inx 2303 34 and and CC cord-010092-uftc8inx 2303 35 at at IN cord-010092-uftc8inx 2303 36 return return NN cord-010092-uftc8inx 2303 37 visit visit NN cord-010092-uftc8inx 2303 38 after after IN cord-010092-uftc8inx 2303 39 low low JJ cord-010092-uftc8inx 2303 40 Hb Hb NNP cord-010092-uftc8inx 2303 41 . . . cord-010092-uftc8inx 2304 1 Yearly yearly JJ cord-010092-uftc8inx 2304 2 testing testing NN cord-010092-uftc8inx 2304 3 of of IN cord-010092-uftc8inx 2304 4 plasma plasma NN cord-010092-uftc8inx 2304 5 and and CC cord-010092-uftc8inx 2304 6 platelet platelet NN cord-010092-uftc8inx 2304 7 donors donor NNS cord-010092-uftc8inx 2304 8 . . . cord-010092-uftc8inx 2305 1 Methods method NNS cord-010092-uftc8inx 2305 2 : : : cord-010092-uftc8inx 2305 3 Ferritin ferritin NN cord-010092-uftc8inx 2305 4 testing testing NN cord-010092-uftc8inx 2305 5 , , , cord-010092-uftc8inx 2305 6 following follow VBG cord-010092-uftc8inx 2305 7 a a DT cord-010092-uftc8inx 2305 8 staff staff NN cord-010092-uftc8inx 2305 9 education education NN cord-010092-uftc8inx 2305 10 program program NN cord-010092-uftc8inx 2305 11 , , , cord-010092-uftc8inx 2305 12 was be VBD cord-010092-uftc8inx 2305 13 implemented implement VBN cord-010092-uftc8inx 2305 14 for for IN cord-010092-uftc8inx 2305 15 applicant applicant NN cord-010092-uftc8inx 2305 16 donors donor NNS cord-010092-uftc8inx 2305 17 , , , cord-010092-uftc8inx 2305 18 donors donor NNS cord-010092-uftc8inx 2305 19 with with IN cord-010092-uftc8inx 2305 20 low low JJ cord-010092-uftc8inx 2305 21 Hb Hb NNP cord-010092-uftc8inx 2305 22 , , , cord-010092-uftc8inx 2305 23 women woman NNS cord-010092-uftc8inx 2305 24 after after IN cord-010092-uftc8inx 2305 25 pregnancy pregnancy NN cord-010092-uftc8inx 2305 26 , , , cord-010092-uftc8inx 2305 27 apheresis apheresis NN cord-010092-uftc8inx 2305 28 donors donor NNS cord-010092-uftc8inx 2305 29 , , , cord-010092-uftc8inx 2305 30 followed follow VBN cord-010092-uftc8inx 2305 31 by by IN cord-010092-uftc8inx 2305 32 screening screening NN cord-010092-uftc8inx 2305 33 of of IN cord-010092-uftc8inx 2305 34 registered registered JJ cord-010092-uftc8inx 2305 35 blood blood NN cord-010092-uftc8inx 2305 36 donors donor NNS cord-010092-uftc8inx 2305 37 per per IN cord-010092-uftc8inx 2305 38 donation donation NN cord-010092-uftc8inx 2305 39 site site NN cord-010092-uftc8inx 2305 40 . . . cord-010092-uftc8inx 2306 1 After after IN cord-010092-uftc8inx 2306 2 initial initial JJ cord-010092-uftc8inx 2306 3 screening screening NN cord-010092-uftc8inx 2306 4 , , , cord-010092-uftc8inx 2306 5 donors donor NNS cord-010092-uftc8inx 2306 6 will will MD cord-010092-uftc8inx 2306 7 be be VB cord-010092-uftc8inx 2306 8 tested test VBN cord-010092-uftc8inx 2306 9 at at IN cord-010092-uftc8inx 2306 10 each each DT cord-010092-uftc8inx 2306 11 4 4 CD cord-010092-uftc8inx 2306 12 th th XX cord-010092-uftc8inx 2306 13 ( ( -LRB- cord-010092-uftc8inx 2306 14 women woman NNS cord-010092-uftc8inx 2306 15 ) ) -RRB- cord-010092-uftc8inx 2306 16 or or CC cord-010092-uftc8inx 2306 17 8 8 CD cord-010092-uftc8inx 2306 18 th th XX cord-010092-uftc8inx 2306 19 ( ( -LRB- cord-010092-uftc8inx 2306 20 men man NNS cord-010092-uftc8inx 2306 21 ) ) -RRB- cord-010092-uftc8inx 2306 22 donation donation NN cord-010092-uftc8inx 2306 23 , , , cord-010092-uftc8inx 2306 24 and and CC cord-010092-uftc8inx 2306 25 with with IN cord-010092-uftc8inx 2306 26 yearly yearly JJ cord-010092-uftc8inx 2306 27 testing testing NN cord-010092-uftc8inx 2306 28 of of IN cord-010092-uftc8inx 2306 29 young young JJ cord-010092-uftc8inx 2306 30 adult adult NN cord-010092-uftc8inx 2306 31 blood blood NN cord-010092-uftc8inx 2306 32 donors donor NNS cord-010092-uftc8inx 2306 33 below below IN cord-010092-uftc8inx 2306 34 25 25 CD cord-010092-uftc8inx 2306 35 years year NNS cord-010092-uftc8inx 2306 36 . . . cord-010092-uftc8inx 2307 1 Six six CD cord-010092-uftc8inx 2307 2 nurses nurse NNS cord-010092-uftc8inx 2307 3 were be VBD cord-010092-uftc8inx 2307 4 educated educate VBN cord-010092-uftc8inx 2307 5 to to TO cord-010092-uftc8inx 2307 6 process process VB cord-010092-uftc8inx 2307 7 ferritin ferritin NN cord-010092-uftc8inx 2307 8 and and CC cord-010092-uftc8inx 2307 9 blood blood NN cord-010092-uftc8inx 2307 10 count count NN cord-010092-uftc8inx 2307 11 results result NNS cord-010092-uftc8inx 2307 12 . . . cord-010092-uftc8inx 2308 1 Donors donor NNS cord-010092-uftc8inx 2308 2 with with IN cord-010092-uftc8inx 2308 3 aberrant aberrant JJ cord-010092-uftc8inx 2308 4 ferritin ferritin NN cord-010092-uftc8inx 2308 5 were be VBD cord-010092-uftc8inx 2308 6 contacted contact VBN cord-010092-uftc8inx 2308 7 by by IN cord-010092-uftc8inx 2308 8 letter letter NN cord-010092-uftc8inx 2308 9 . . . cord-010092-uftc8inx 2309 1 Results result NNS cord-010092-uftc8inx 2309 2 : : : cord-010092-uftc8inx 2310 1 Establishment establishment NN cord-010092-uftc8inx 2310 2 of of IN cord-010092-uftc8inx 2310 3 cut cut VB cord-010092-uftc8inx 2310 4 - - HYPH cord-010092-uftc8inx 2310 5 off off RP cord-010092-uftc8inx 2310 6 levels level NNS cord-010092-uftc8inx 2310 7 and and CC cord-010092-uftc8inx 2310 8 algorithms algorithm NNS cord-010092-uftc8inx 2310 9 for for IN cord-010092-uftc8inx 2310 10 ferritin ferritin NN cord-010092-uftc8inx 2310 11 testing testing NN cord-010092-uftc8inx 2310 12 and and CC cord-010092-uftc8inx 2310 13 iron iron NN cord-010092-uftc8inx 2310 14 treatment treatment NN cord-010092-uftc8inx 2310 15 was be VBD cord-010092-uftc8inx 2310 16 evidence evidence NN cord-010092-uftc8inx 2310 17 based base VBN cord-010092-uftc8inx 2310 18 but but CC cord-010092-uftc8inx 2310 19 met meet VBD cord-010092-uftc8inx 2310 20 practical practical JJ cord-010092-uftc8inx 2310 21 limitations limitation NNS cord-010092-uftc8inx 2310 22 such such JJ cord-010092-uftc8inx 2310 23 as as IN cord-010092-uftc8inx 2310 24 number number NN cord-010092-uftc8inx 2310 25 of of IN cord-010092-uftc8inx 2310 26 analyses analysis NNS cord-010092-uftc8inx 2310 27 and and CC cord-010092-uftc8inx 2310 28 results result NNS cord-010092-uftc8inx 2310 29 that that WDT cord-010092-uftc8inx 2310 30 could could MD cord-010092-uftc8inx 2310 31 be be VB cord-010092-uftc8inx 2310 32 processed process VBN cord-010092-uftc8inx 2310 33 per per IN cord-010092-uftc8inx 2310 34 week week NN cord-010092-uftc8inx 2310 35 , , , cord-010092-uftc8inx 2310 36 limitations limitation NNS cord-010092-uftc8inx 2310 37 in in IN cord-010092-uftc8inx 2310 38 LISS LISS NNP cord-010092-uftc8inx 2310 39 set set VBN cord-010092-uftc8inx 2310 40 - - HYPH cord-010092-uftc8inx 2310 41 up up RP cord-010092-uftc8inx 2310 42 , , , cord-010092-uftc8inx 2310 43 blood blood NN cord-010092-uftc8inx 2310 44 demand demand NN cord-010092-uftc8inx 2310 45 contra contra NNP cord-010092-uftc8inx 2310 46 preferred prefer VBD cord-010092-uftc8inx 2310 47 cut cut NN cord-010092-uftc8inx 2310 48 - - HYPH cord-010092-uftc8inx 2310 49 offs off NNS cord-010092-uftc8inx 2310 50 , , , cord-010092-uftc8inx 2310 51 iron iron NN cord-010092-uftc8inx 2310 52 supplementation supplementation NN cord-010092-uftc8inx 2310 53 compliance compliance NN cord-010092-uftc8inx 2310 54 . . . cord-010092-uftc8inx 2311 1 For for IN cord-010092-uftc8inx 2311 2 applicant applicant NN cord-010092-uftc8inx 2311 3 donors donor NNS cord-010092-uftc8inx 2311 4 , , , cord-010092-uftc8inx 2311 5 Hb Hb NNP cord-010092-uftc8inx 2311 6 testing testing NN cord-010092-uftc8inx 2311 7 show show VBP cord-010092-uftc8inx 2311 8 that that IN cord-010092-uftc8inx 2311 9 20 20 CD cord-010092-uftc8inx 2311 10 % % NN cord-010092-uftc8inx 2311 11 of of IN cord-010092-uftc8inx 2311 12 female female NN cord-010092-uftc8inx 2311 13 and and CC cord-010092-uftc8inx 2311 14 9 9 CD cord-010092-uftc8inx 2311 15 % % NN cord-010092-uftc8inx 2311 16 of of IN cord-010092-uftc8inx 2311 17 male male JJ cord-010092-uftc8inx 2311 18 applicants applicant NNS cord-010092-uftc8inx 2311 19 can can MD cord-010092-uftc8inx 2311 20 not not RB cord-010092-uftc8inx 2311 21 be be VB cord-010092-uftc8inx 2311 22 registered register VBN cord-010092-uftc8inx 2311 23 because because IN cord-010092-uftc8inx 2311 24 of of IN cord-010092-uftc8inx 2311 25 low low JJ cord-010092-uftc8inx 2311 26 Hb Hb NNP cord-010092-uftc8inx 2311 27 ( ( -LRB- cord-010092-uftc8inx 2311 28 125 125 CD cord-010092-uftc8inx 2311 29 and and CC cord-010092-uftc8inx 2311 30 135 135 CD cord-010092-uftc8inx 2311 31 mg mg NNP cord-010092-uftc8inx 2311 32 / / SYM cord-010092-uftc8inx 2311 33 L L NNP cord-010092-uftc8inx 2311 34 respectively respectively RB cord-010092-uftc8inx 2311 35 ) ) -RRB- cord-010092-uftc8inx 2311 36 . . . cord-010092-uftc8inx 2312 1 Adding add VBG cord-010092-uftc8inx 2312 2 ferritin ferritin NN cord-010092-uftc8inx 2312 3 testing testing NN cord-010092-uftc8inx 2312 4 , , , cord-010092-uftc8inx 2312 5 a a DT cord-010092-uftc8inx 2312 6 preferred preferred JJ cord-010092-uftc8inx 2312 7 cut cut NN cord-010092-uftc8inx 2312 8 - - HYPH cord-010092-uftc8inx 2312 9 off off RP cord-010092-uftc8inx 2312 10 level level NN cord-010092-uftc8inx 2312 11 of of IN cord-010092-uftc8inx 2312 12 30 30 CD cord-010092-uftc8inx 2312 13 lg lg NN cord-010092-uftc8inx 2312 14 / / SYM cord-010092-uftc8inx 2312 15 mL mL NNP cord-010092-uftc8inx 2312 16 ( ( -LRB- cord-010092-uftc8inx 2312 17 male male JJ cord-010092-uftc8inx 2312 18 reference reference NN cord-010092-uftc8inx 2312 19 level level NN cord-010092-uftc8inx 2312 20 ) ) -RRB- cord-010092-uftc8inx 2312 21 , , , cord-010092-uftc8inx 2312 22 would would MD cord-010092-uftc8inx 2312 23 result result VB cord-010092-uftc8inx 2312 24 in in IN cord-010092-uftc8inx 2312 25 additionally additionally RB cord-010092-uftc8inx 2312 26 24 24 CD cord-010092-uftc8inx 2312 27 % % NN cord-010092-uftc8inx 2312 28 female female NN cord-010092-uftc8inx 2312 29 and and CC cord-010092-uftc8inx 2312 30 1.3 1.3 CD cord-010092-uftc8inx 2312 31 % % NN cord-010092-uftc8inx 2312 32 male male JJ cord-010092-uftc8inx 2312 33 applicant applicant NN cord-010092-uftc8inx 2312 34 donor donor NN cord-010092-uftc8inx 2312 35 loss loss NN cord-010092-uftc8inx 2312 36 . . . cord-010092-uftc8inx 2313 1 As as IN cord-010092-uftc8inx 2313 2 this this DT cord-010092-uftc8inx 2313 3 would would MD cord-010092-uftc8inx 2313 4 threat threat VB cord-010092-uftc8inx 2313 5 the the DT cord-010092-uftc8inx 2313 6 blood blood NN cord-010092-uftc8inx 2313 7 demand demand NN cord-010092-uftc8inx 2313 8 , , , cord-010092-uftc8inx 2313 9 cut cut VBN cord-010092-uftc8inx 2313 10 - - HYPH cord-010092-uftc8inx 2313 11 off off NN cord-010092-uftc8inx 2313 12 was be VBD cord-010092-uftc8inx 2313 13 set set VBN cord-010092-uftc8inx 2313 14 to to IN cord-010092-uftc8inx 2313 15 15 15 CD cord-010092-uftc8inx 2313 16 lg lg NN cord-010092-uftc8inx 2313 17 / / SYM cord-010092-uftc8inx 2313 18 mL ml NN cord-010092-uftc8inx 2313 19 for for IN cord-010092-uftc8inx 2313 20 women woman NNS cord-010092-uftc8inx 2313 21 , , , cord-010092-uftc8inx 2313 22 above above IN cord-010092-uftc8inx 2313 23 the the DT cord-010092-uftc8inx 2313 24 female female JJ cord-010092-uftc8inx 2313 25 reference reference NN cord-010092-uftc8inx 2313 26 10 10 CD cord-010092-uftc8inx 2313 27 lg lg NNP cord-010092-uftc8inx 2313 28 / / SYM cord-010092-uftc8inx 2313 29 mL mL NNP cord-010092-uftc8inx 2313 30 , , , cord-010092-uftc8inx 2313 31 with with IN cord-010092-uftc8inx 2313 32 an an DT cord-010092-uftc8inx 2313 33 acceptable acceptable JJ cord-010092-uftc8inx 2313 34 6 6 CD cord-010092-uftc8inx 2313 35 % % NN cord-010092-uftc8inx 2313 36 loss loss NN cord-010092-uftc8inx 2313 37 of of IN cord-010092-uftc8inx 2313 38 female female JJ cord-010092-uftc8inx 2313 39 applicant applicant NN cord-010092-uftc8inx 2313 40 donors donor NNS cord-010092-uftc8inx 2313 41 . . . cord-010092-uftc8inx 2314 1 For for IN cord-010092-uftc8inx 2314 2 registered registered JJ cord-010092-uftc8inx 2314 3 blood blood NN cord-010092-uftc8inx 2314 4 donors donor NNS cord-010092-uftc8inx 2314 5 , , , cord-010092-uftc8inx 2314 6 4000 4000 CD cord-010092-uftc8inx 2314 7 mg mg NN cord-010092-uftc8inx 2314 8 of of IN cord-010092-uftc8inx 2314 9 extra extra JJ cord-010092-uftc8inx 2314 10 iron iron NN cord-010092-uftc8inx 2314 11 tablets tablet NNS cord-010092-uftc8inx 2314 12 were be VBD cord-010092-uftc8inx 2314 13 offered offer VBN cord-010092-uftc8inx 2314 14 at at IN cord-010092-uftc8inx 2314 15 low low JJ cord-010092-uftc8inx 2314 16 ferritin ferritin NN cord-010092-uftc8inx 2314 17 ( ( -LRB- cord-010092-uftc8inx 2314 18 10 10 CD cord-010092-uftc8inx 2314 19 - - SYM cord-010092-uftc8inx 2314 20 29 29 CD cord-010092-uftc8inx 2314 21 lg lg NNP cord-010092-uftc8inx 2314 22 / / SYM cord-010092-uftc8inx 2314 23 mL mL NNP cord-010092-uftc8inx 2314 24 ) ) -RRB- cord-010092-uftc8inx 2314 25 . . . cord-010092-uftc8inx 2315 1 This this DT cord-010092-uftc8inx 2315 2 was be VBD cord-010092-uftc8inx 2315 3 sometimes sometimes RB cord-010092-uftc8inx 2315 4 combined combine VBN cord-010092-uftc8inx 2315 5 with with IN cord-010092-uftc8inx 2315 6 prolonged prolonged JJ cord-010092-uftc8inx 2315 7 intervals interval NNS cord-010092-uftc8inx 2315 8 and and CC cord-010092-uftc8inx 2315 9 often often RB cord-010092-uftc8inx 2315 10 repeated repeat VBN cord-010092-uftc8inx 2315 11 before before IN cord-010092-uftc8inx 2315 12 ferritin ferritin NN cord-010092-uftc8inx 2315 13 was be VBD cord-010092-uftc8inx 2315 14 restored restore VBN cord-010092-uftc8inx 2315 15 above above IN cord-010092-uftc8inx 2315 16 30 30 CD cord-010092-uftc8inx 2315 17 lg lg NNP cord-010092-uftc8inx 2315 18 / / SYM cord-010092-uftc8inx 2315 19 mL. mL. NNP cord-010092-uftc8inx 2315 20 Donors donor NNS cord-010092-uftc8inx 2315 21 with with IN cord-010092-uftc8inx 2315 22 ferritin ferritin NN cord-010092-uftc8inx 2315 23 below below IN cord-010092-uftc8inx 2315 24 10 10 CD cord-010092-uftc8inx 2315 25 lg lg NNP cord-010092-uftc8inx 2315 26 / / SYM cord-010092-uftc8inx 2315 27 mL mL NNP cord-010092-uftc8inx 2315 28 ( ( -LRB- cord-010092-uftc8inx 2315 29 in in IN cord-010092-uftc8inx 2315 30 0.6 0.6 CD cord-010092-uftc8inx 2315 31 % % NN cord-010092-uftc8inx 2315 32 applicant applicant NN cord-010092-uftc8inx 2315 33 donors donor NNS cord-010092-uftc8inx 2315 34 , , , cord-010092-uftc8inx 2315 35 0.8 0.8 CD cord-010092-uftc8inx 2315 36 % % NN cord-010092-uftc8inx 2315 37 registered register VBN cord-010092-uftc8inx 2315 38 donors donor NNS cord-010092-uftc8inx 2315 39 ) ) -RRB- cord-010092-uftc8inx 2315 40 or or CC cord-010092-uftc8inx 2315 41 above above IN cord-010092-uftc8inx 2315 42 600 600 CD cord-010092-uftc8inx 2315 43 lg lg NN cord-010092-uftc8inx 2315 44 / / SYM cord-010092-uftc8inx 2315 45 mL mL NNP cord-010092-uftc8inx 2315 46 ( ( -LRB- cord-010092-uftc8inx 2315 47 0.5 0.5 CD cord-010092-uftc8inx 2315 48 % % NN cord-010092-uftc8inx 2315 49 applicant applicant NN cord-010092-uftc8inx 2315 50 donors donor NNS cord-010092-uftc8inx 2315 51 , , , cord-010092-uftc8inx 2315 52 0.1 0.1 CD cord-010092-uftc8inx 2315 53 % % NN cord-010092-uftc8inx 2315 54 registered register VBN cord-010092-uftc8inx 2315 55 donors donor NNS cord-010092-uftc8inx 2315 56 ) ) -RRB- cord-010092-uftc8inx 2315 57 were be VBD cord-010092-uftc8inx 2315 58 deferred defer VBN cord-010092-uftc8inx 2315 59 and and CC cord-010092-uftc8inx 2315 60 recommended recommend VBN cord-010092-uftc8inx 2315 61 to to TO cord-010092-uftc8inx 2315 62 see see VB cord-010092-uftc8inx 2315 63 their -PRON- PRP$ cord-010092-uftc8inx 2315 64 physician physician NN cord-010092-uftc8inx 2315 65 . . . cord-010092-uftc8inx 2316 1 For for IN cord-010092-uftc8inx 2316 2 Hb Hb NNP cord-010092-uftc8inx 2316 3 deferral deferral NN cord-010092-uftc8inx 2316 4 , , , cord-010092-uftc8inx 2316 5 the the DT cord-010092-uftc8inx 2316 6 interval interval NN cord-010092-uftc8inx 2316 7 was be VBD cord-010092-uftc8inx 2316 8 prolonged prolong VBN cord-010092-uftc8inx 2316 9 from from IN cord-010092-uftc8inx 2316 10 3 3 CD cord-010092-uftc8inx 2316 11 to to TO cord-010092-uftc8inx 2316 12 5 5 CD cord-010092-uftc8inx 2316 13 months month NNS cord-010092-uftc8inx 2316 14 , , , cord-010092-uftc8inx 2316 15 irrespective irrespective RB cord-010092-uftc8inx 2316 16 of of IN cord-010092-uftc8inx 2316 17 ferritin ferritin NN cord-010092-uftc8inx 2316 18 levels level NNS cord-010092-uftc8inx 2316 19 . . . cord-010092-uftc8inx 2317 1 This this DT cord-010092-uftc8inx 2317 2 , , , cord-010092-uftc8inx 2317 3 together together RB cord-010092-uftc8inx 2317 4 with with IN cord-010092-uftc8inx 2317 5 iron iron NN cord-010092-uftc8inx 2317 6 supplementation supplementation NN cord-010092-uftc8inx 2317 7 , , , cord-010092-uftc8inx 2317 8 resulted result VBD cord-010092-uftc8inx 2317 9 in in IN cord-010092-uftc8inx 2317 10 an an DT cord-010092-uftc8inx 2317 11 increase increase NN cord-010092-uftc8inx 2317 12 from from IN cord-010092-uftc8inx 2317 13 50 50 CD cord-010092-uftc8inx 2317 14 % % NN cord-010092-uftc8inx 2317 15 to to TO cord-010092-uftc8inx 2317 16 70 70 CD cord-010092-uftc8inx 2317 17 % % NN cord-010092-uftc8inx 2317 18 approved approve VBN cord-010092-uftc8inx 2317 19 Hb Hb NNP cord-010092-uftc8inx 2317 20 at at IN cord-010092-uftc8inx 2317 21 return return NN cord-010092-uftc8inx 2317 22 . . . cord-010092-uftc8inx 2318 1 The the DT cord-010092-uftc8inx 2318 2 team team NN cord-010092-uftc8inx 2318 3 of of IN cord-010092-uftc8inx 2318 4 nurses nurse NNS cord-010092-uftc8inx 2318 5 processing process VBG cord-010092-uftc8inx 2318 6 ferritin ferritin NN cord-010092-uftc8inx 2318 7 and and CC cord-010092-uftc8inx 2318 8 blood blood NN cord-010092-uftc8inx 2318 9 count count NN cord-010092-uftc8inx 2318 10 results result NNS cord-010092-uftc8inx 2318 11 ( ( -LRB- cord-010092-uftc8inx 2318 12 1½ 1½ CD cord-010092-uftc8inx 2318 13 nurse nurse NN cord-010092-uftc8inx 2318 14 fulltime fulltime JJ cord-010092-uftc8inx 2318 15 weekdays weekday NNS cord-010092-uftc8inx 2318 16 ) ) -RRB- cord-010092-uftc8inx 2318 17 reacted react VBD cord-010092-uftc8inx 2318 18 to to IN cord-010092-uftc8inx 2318 19 approximately approximately RB cord-010092-uftc8inx 2318 20 40 40 CD cord-010092-uftc8inx 2318 21 donor donor NN cord-010092-uftc8inx 2318 22 results result NNS cord-010092-uftc8inx 2318 23 daily daily RB cord-010092-uftc8inx 2318 24 , , , cord-010092-uftc8inx 2318 25 representing represent VBG cord-010092-uftc8inx 2318 26 20 20 CD cord-010092-uftc8inx 2318 27 % % NN cord-010092-uftc8inx 2318 28 of of IN cord-010092-uftc8inx 2318 29 test test NN cord-010092-uftc8inx 2318 30 results result NNS cord-010092-uftc8inx 2318 31 . . . cord-010092-uftc8inx 2319 1 Summary Summary NNP cord-010092-uftc8inx 2319 2 / / SYM cord-010092-uftc8inx 2319 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 2319 4 : : : cord-010092-uftc8inx 2320 1 Many many JJ cord-010092-uftc8inx 2320 2 female female JJ cord-010092-uftc8inx 2320 3 donor donor NN cord-010092-uftc8inx 2320 4 applicants applicant NNS cord-010092-uftc8inx 2320 5 have have VBP cord-010092-uftc8inx 2320 6 suboptimal suboptimal JJ cord-010092-uftc8inx 2320 7 ferritin ferritin NN cord-010092-uftc8inx 2320 8 levels level NNS cord-010092-uftc8inx 2320 9 although although IN cord-010092-uftc8inx 2320 10 they -PRON- PRP cord-010092-uftc8inx 2320 11 meet meet VBP cord-010092-uftc8inx 2320 12 required require VBN cord-010092-uftc8inx 2320 13 Hb Hb NNP cord-010092-uftc8inx 2320 14 for for IN cord-010092-uftc8inx 2320 15 donation donation NN cord-010092-uftc8inx 2320 16 . . . cord-010092-uftc8inx 2321 1 Iron iron NN cord-010092-uftc8inx 2321 2 treatment treatment NN cord-010092-uftc8inx 2321 3 was be VBD cord-010092-uftc8inx 2321 4 added add VBN cord-010092-uftc8inx 2321 5 to to TO cord-010092-uftc8inx 2321 6 retain retain VB cord-010092-uftc8inx 2321 7 donors donor NNS cord-010092-uftc8inx 2321 8 with with IN cord-010092-uftc8inx 2321 9 low low JJ cord-010092-uftc8inx 2321 10 ferritin ferritin NN cord-010092-uftc8inx 2321 11 as as IN cord-010092-uftc8inx 2321 12 only only RB cord-010092-uftc8inx 2321 13 prolonged prolong VBN cord-010092-uftc8inx 2321 14 intervals interval NNS cord-010092-uftc8inx 2321 15 may may MD cord-010092-uftc8inx 2321 16 danger danger VB cord-010092-uftc8inx 2321 17 the the DT cord-010092-uftc8inx 2321 18 blood blood NN cord-010092-uftc8inx 2321 19 supply supply NN cord-010092-uftc8inx 2321 20 . . . cord-010092-uftc8inx 2322 1 For for IN cord-010092-uftc8inx 2322 2 implementation implementation NN cord-010092-uftc8inx 2322 3 of of IN cord-010092-uftc8inx 2322 4 ferritin ferritin NN cord-010092-uftc8inx 2322 5 testing testing NN cord-010092-uftc8inx 2322 6 , , , cord-010092-uftc8inx 2322 7 it -PRON- PRP cord-010092-uftc8inx 2322 8 is be VBZ cord-010092-uftc8inx 2322 9 necessary necessary JJ cord-010092-uftc8inx 2322 10 to to TO cord-010092-uftc8inx 2322 11 have have VB cord-010092-uftc8inx 2322 12 a a DT cord-010092-uftc8inx 2322 13 well well RB cord-010092-uftc8inx 2322 14 - - HYPH cord-010092-uftc8inx 2322 15 functioning function VBG cord-010092-uftc8inx 2322 16 and and CC cord-010092-uftc8inx 2322 17 agile agile JJ cord-010092-uftc8inx 2322 18 organization organization NN cord-010092-uftc8inx 2322 19 to to TO cord-010092-uftc8inx 2322 20 create create VB cord-010092-uftc8inx 2322 21 and and CC cord-010092-uftc8inx 2322 22 apply apply VB cord-010092-uftc8inx 2322 23 algorithms algorithm NNS cord-010092-uftc8inx 2322 24 for for IN cord-010092-uftc8inx 2322 25 testing testing NN cord-010092-uftc8inx 2322 26 , , , cord-010092-uftc8inx 2322 27 extension extension NN cord-010092-uftc8inx 2322 28 of of IN cord-010092-uftc8inx 2322 29 intervals interval NNS cord-010092-uftc8inx 2322 30 and and CC cord-010092-uftc8inx 2322 31 iron iron NN cord-010092-uftc8inx 2322 32 treatment treatment NN cord-010092-uftc8inx 2322 33 . . . cord-010092-uftc8inx 2323 1 Background background NN cord-010092-uftc8inx 2323 2 : : : cord-010092-uftc8inx 2324 1 Since since IN cord-010092-uftc8inx 2324 2 November November NNP cord-010092-uftc8inx 2324 3 2017 2017 CD cord-010092-uftc8inx 2324 4 a a DT cord-010092-uftc8inx 2324 5 new new JJ cord-010092-uftc8inx 2324 6 donor donor NN cord-010092-uftc8inx 2324 7 screening screening NN cord-010092-uftc8inx 2324 8 regime regime NN cord-010092-uftc8inx 2324 9 is be VBZ cord-010092-uftc8inx 2324 10 introduced introduce VBN cord-010092-uftc8inx 2324 11 in in IN cord-010092-uftc8inx 2324 12 the the DT cord-010092-uftc8inx 2324 13 Netherlands Netherlands NNP cord-010092-uftc8inx 2324 14 where where WRB cord-010092-uftc8inx 2324 15 serum serum NN cord-010092-uftc8inx 2324 16 ferritin ferritin NN cord-010092-uftc8inx 2324 17 levels level NNS cord-010092-uftc8inx 2324 18 in in IN cord-010092-uftc8inx 2324 19 whole whole JJ cord-010092-uftc8inx 2324 20 blood blood NN cord-010092-uftc8inx 2324 21 donors donor NNS cord-010092-uftc8inx 2324 22 are be VBP cord-010092-uftc8inx 2324 23 measured measure VBN cord-010092-uftc8inx 2324 24 periodically periodically RB cord-010092-uftc8inx 2324 25 to to TO cord-010092-uftc8inx 2324 26 further further RB cord-010092-uftc8inx 2324 27 control control VB cord-010092-uftc8inx 2324 28 potential potential JJ cord-010092-uftc8inx 2324 29 iron iron NN cord-010092-uftc8inx 2324 30 deficiency deficiency NN cord-010092-uftc8inx 2324 31 in in IN cord-010092-uftc8inx 2324 32 donors donor NNS cord-010092-uftc8inx 2324 33 . . . cord-010092-uftc8inx 2325 1 Donor donor NN cord-010092-uftc8inx 2325 2 deferral deferral NN cord-010092-uftc8inx 2325 3 thresholds threshold NNS cord-010092-uftc8inx 2325 4 are be VBP cord-010092-uftc8inx 2325 5 set set VBN cord-010092-uftc8inx 2325 6 at at IN cord-010092-uftc8inx 2325 7 30 30 CD cord-010092-uftc8inx 2325 8 and and CC cord-010092-uftc8inx 2325 9 15 15 CD cord-010092-uftc8inx 2325 10 ng ng NN cord-010092-uftc8inx 2325 11 / / SYM cord-010092-uftc8inx 2325 12 mL mL NNP cord-010092-uftc8inx 2325 13 , , , cord-010092-uftc8inx 2325 14 and and CC cord-010092-uftc8inx 2325 15 donors donor NNS cord-010092-uftc8inx 2325 16 are be VBP cord-010092-uftc8inx 2325 17 deferred defer VBN cord-010092-uftc8inx 2325 18 for for IN cord-010092-uftc8inx 2325 19 six six CD cord-010092-uftc8inx 2325 20 and and CC cord-010092-uftc8inx 2325 21 twelve twelve CD cord-010092-uftc8inx 2325 22 months month NNS cord-010092-uftc8inx 2325 23 respectively respectively RB cord-010092-uftc8inx 2325 24 if if IN cord-010092-uftc8inx 2325 25 ferritin ferritin NN cord-010092-uftc8inx 2325 26 levels level NNS cord-010092-uftc8inx 2325 27 are be VBP cord-010092-uftc8inx 2325 28 below below IN cord-010092-uftc8inx 2325 29 these these DT cord-010092-uftc8inx 2325 30 values value NNS cord-010092-uftc8inx 2325 31 . . . cord-010092-uftc8inx 2326 1 As as IN cord-010092-uftc8inx 2326 2 limited limited JJ cord-010092-uftc8inx 2326 3 information information NN cord-010092-uftc8inx 2326 4 is be VBZ cord-010092-uftc8inx 2326 5 available available JJ cord-010092-uftc8inx 2326 6 on on IN cord-010092-uftc8inx 2326 7 ferritin ferritin NN cord-010092-uftc8inx 2326 8 recovery recovery NN cord-010092-uftc8inx 2326 9 in in IN cord-010092-uftc8inx 2326 10 whole whole JJ cord-010092-uftc8inx 2326 11 - - HYPH cord-010092-uftc8inx 2326 12 blood blood NN cord-010092-uftc8inx 2326 13 donors donor NNS cord-010092-uftc8inx 2326 14 , , , cord-010092-uftc8inx 2326 15 the the DT cord-010092-uftc8inx 2326 16 policy policy NN cord-010092-uftc8inx 2326 17 is be VBZ cord-010092-uftc8inx 2326 18 introduced introduce VBN cord-010092-uftc8inx 2326 19 in in IN cord-010092-uftc8inx 2326 20 parts part NNS cord-010092-uftc8inx 2326 21 such such JJ cord-010092-uftc8inx 2326 22 that that IN cord-010092-uftc8inx 2326 23 adaptations adaptation NNS cord-010092-uftc8inx 2326 24 to to IN cord-010092-uftc8inx 2326 25 the the DT cord-010092-uftc8inx 2326 26 implementation implementation NN cord-010092-uftc8inx 2326 27 may may MD cord-010092-uftc8inx 2326 28 be be VB cord-010092-uftc8inx 2326 29 considered consider VBN cord-010092-uftc8inx 2326 30 based base VBN cord-010092-uftc8inx 2326 31 on on IN cord-010092-uftc8inx 2326 32 intermediate intermediate JJ cord-010092-uftc8inx 2326 33 results result NNS cord-010092-uftc8inx 2326 34 and and CC cord-010092-uftc8inx 2326 35 the the DT cord-010092-uftc8inx 2326 36 impact impact NN cord-010092-uftc8inx 2326 37 of of IN cord-010092-uftc8inx 2326 38 the the DT cord-010092-uftc8inx 2326 39 measure measure NN cord-010092-uftc8inx 2326 40 on on IN cord-010092-uftc8inx 2326 41 donor donor NN cord-010092-uftc8inx 2326 42 well well RB cord-010092-uftc8inx 2326 43 - - HYPH cord-010092-uftc8inx 2326 44 being being NN cord-010092-uftc8inx 2326 45 can can MD cord-010092-uftc8inx 2326 46 be be VB cord-010092-uftc8inx 2326 47 evaluated evaluate VBN cord-010092-uftc8inx 2326 48 . . . cord-010092-uftc8inx 2327 1 Aims aim VBZ cord-010092-uftc8inx 2327 2 : : : cord-010092-uftc8inx 2327 3 To to TO cord-010092-uftc8inx 2327 4 assess assess VB cord-010092-uftc8inx 2327 5 the the DT cord-010092-uftc8inx 2327 6 effect effect NN cord-010092-uftc8inx 2327 7 of of IN cord-010092-uftc8inx 2327 8 donor donor NN cord-010092-uftc8inx 2327 9 deferral deferral NN cord-010092-uftc8inx 2327 10 on on IN cord-010092-uftc8inx 2327 11 donor donor NN cord-010092-uftc8inx 2327 12 ferritin ferritin NN cord-010092-uftc8inx 2327 13 levels level NNS cord-010092-uftc8inx 2327 14 . . . cord-010092-uftc8inx 2328 1 Methods method NNS cord-010092-uftc8inx 2328 2 : : : cord-010092-uftc8inx 2328 3 Ferritin ferritin NN cord-010092-uftc8inx 2328 4 levels level NNS cord-010092-uftc8inx 2328 5 are be VBP cord-010092-uftc8inx 2328 6 measured measure VBN cord-010092-uftc8inx 2328 7 in in IN cord-010092-uftc8inx 2328 8 new new JJ cord-010092-uftc8inx 2328 9 donors donor NNS cord-010092-uftc8inx 2328 10 and and CC cord-010092-uftc8inx 2328 11 at at IN cord-010092-uftc8inx 2328 12 every every DT cord-010092-uftc8inx 2328 13 fifth fifth JJ cord-010092-uftc8inx 2328 14 donation donation NN cord-010092-uftc8inx 2328 15 in in IN cord-010092-uftc8inx 2328 16 repeat repeat NN cord-010092-uftc8inx 2328 17 donors donor NNS cord-010092-uftc8inx 2328 18 . . . cord-010092-uftc8inx 2329 1 Donors donor NNS cord-010092-uftc8inx 2329 2 with with IN cord-010092-uftc8inx 2329 3 ferritin ferritin NN cord-010092-uftc8inx 2329 4 levels level NNS cord-010092-uftc8inx 2329 5 below below IN cord-010092-uftc8inx 2329 6 the the DT cord-010092-uftc8inx 2329 7 indicated indicate VBN cord-010092-uftc8inx 2329 8 thresholds threshold NNS cord-010092-uftc8inx 2329 9 are be VBP cord-010092-uftc8inx 2329 10 deferred defer VBN cord-010092-uftc8inx 2329 11 and and CC cord-010092-uftc8inx 2329 12 ferritin ferritin NN cord-010092-uftc8inx 2329 13 is be VBZ cord-010092-uftc8inx 2329 14 re re VBG cord-010092-uftc8inx 2329 15 - - VBN cord-010092-uftc8inx 2329 16 evaluated evaluate VBN cord-010092-uftc8inx 2329 17 at at IN cord-010092-uftc8inx 2329 18 their -PRON- PRP$ cord-010092-uftc8inx 2329 19 return return NN cord-010092-uftc8inx 2329 20 for for IN cord-010092-uftc8inx 2329 21 donation donation NN cord-010092-uftc8inx 2329 22 after after IN cord-010092-uftc8inx 2329 23 six six CD cord-010092-uftc8inx 2329 24 or or CC cord-010092-uftc8inx 2329 25 twelve twelve CD cord-010092-uftc8inx 2329 26 months month NNS cord-010092-uftc8inx 2329 27 . . . cord-010092-uftc8inx 2330 1 The the DT cord-010092-uftc8inx 2330 2 policy policy NN cord-010092-uftc8inx 2330 3 allows allow VBZ cord-010092-uftc8inx 2330 4 estimating estimate VBG cord-010092-uftc8inx 2330 5 long long JJ cord-010092-uftc8inx 2330 6 term term NN cord-010092-uftc8inx 2330 7 trends trend NNS cord-010092-uftc8inx 2330 8 in in IN cord-010092-uftc8inx 2330 9 ferritin ferritin NN cord-010092-uftc8inx 2330 10 levels level NNS cord-010092-uftc8inx 2330 11 post post NN cord-010092-uftc8inx 2330 12 donation donation NN cord-010092-uftc8inx 2330 13 in in IN cord-010092-uftc8inx 2330 14 repeat repeat NN cord-010092-uftc8inx 2330 15 donors donor NNS cord-010092-uftc8inx 2330 16 . . . cord-010092-uftc8inx 2331 1 As as IN cord-010092-uftc8inx 2331 2 ferritin ferritin NN cord-010092-uftc8inx 2331 3 levels level NNS cord-010092-uftc8inx 2331 4 are be VBP cord-010092-uftc8inx 2331 5 measured measure VBN cord-010092-uftc8inx 2331 6 in in IN cord-010092-uftc8inx 2331 7 all all DT cord-010092-uftc8inx 2331 8 new new JJ cord-010092-uftc8inx 2331 9 donors donor NNS cord-010092-uftc8inx 2331 10 a a DT cord-010092-uftc8inx 2331 11 reference reference NN cord-010092-uftc8inx 2331 12 distribution distribution NN cord-010092-uftc8inx 2331 13 of of IN cord-010092-uftc8inx 2331 14 ferritin ferritin NN cord-010092-uftc8inx 2331 15 levels level NNS cord-010092-uftc8inx 2331 16 in in IN cord-010092-uftc8inx 2331 17 healthy healthy JJ cord-010092-uftc8inx 2331 18 individuals individual NNS cord-010092-uftc8inx 2331 19 is be VBZ cord-010092-uftc8inx 2331 20 obtained obtain VBN cord-010092-uftc8inx 2331 21 as as RB cord-010092-uftc8inx 2331 22 well well RB cord-010092-uftc8inx 2331 23 . . . cord-010092-uftc8inx 2332 1 Results result NNS cord-010092-uftc8inx 2332 2 : : : cord-010092-uftc8inx 2333 1 Among among IN cord-010092-uftc8inx 2333 2 repeat repeat NN cord-010092-uftc8inx 2333 3 donors donor NNS cord-010092-uftc8inx 2333 4 46 46 CD cord-010092-uftc8inx 2333 5 % % NN cord-010092-uftc8inx 2333 6 ( ( -LRB- cord-010092-uftc8inx 2333 7 44 44 CD cord-010092-uftc8inx 2333 8 % % NN cord-010092-uftc8inx 2333 9 of of IN cord-010092-uftc8inx 2333 10 16,433 16,433 CD cord-010092-uftc8inx 2333 11 male male JJ cord-010092-uftc8inx 2333 12 donors donor NNS cord-010092-uftc8inx 2333 13 , , , cord-010092-uftc8inx 2333 14 and and CC cord-010092-uftc8inx 2333 15 48 48 CD cord-010092-uftc8inx 2333 16 % % NN cord-010092-uftc8inx 2333 17 of of IN cord-010092-uftc8inx 2333 18 13,525 13,525 CD cord-010092-uftc8inx 2333 19 female female JJ cord-010092-uftc8inx 2333 20 donors donor NNS cord-010092-uftc8inx 2333 21 ) ) -RRB- cord-010092-uftc8inx 2333 22 have have VBP cord-010092-uftc8inx 2333 23 ferritin ferritin NN cord-010092-uftc8inx 2333 24 levels level NNS cord-010092-uftc8inx 2333 25 below below IN cord-010092-uftc8inx 2333 26 30 30 CD cord-010092-uftc8inx 2333 27 ng ng NN cord-010092-uftc8inx 2333 28 / / SYM cord-010092-uftc8inx 2333 29 mL ml NN cord-010092-uftc8inx 2333 30 and and CC cord-010092-uftc8inx 2333 31 are be VBP cord-010092-uftc8inx 2333 32 deferred defer VBN cord-010092-uftc8inx 2333 33 for for IN cord-010092-uftc8inx 2333 34 their -PRON- PRP$ cord-010092-uftc8inx 2333 35 next next JJ cord-010092-uftc8inx 2333 36 donation donation NN cord-010092-uftc8inx 2333 37 . . . cord-010092-uftc8inx 2334 1 Furthermore furthermore RB cord-010092-uftc8inx 2334 2 , , , cord-010092-uftc8inx 2334 3 the the DT cord-010092-uftc8inx 2334 4 distributions distribution NNS cord-010092-uftc8inx 2334 5 of of IN cord-010092-uftc8inx 2334 6 ferritin ferritin NN cord-010092-uftc8inx 2334 7 levels level NNS cord-010092-uftc8inx 2334 8 in in IN cord-010092-uftc8inx 2334 9 repeat repeat NN cord-010092-uftc8inx 2334 10 male male JJ cord-010092-uftc8inx 2334 11 and and CC cord-010092-uftc8inx 2334 12 female female JJ cord-010092-uftc8inx 2334 13 donors donor NNS cord-010092-uftc8inx 2334 14 are be VBP cord-010092-uftc8inx 2334 15 similar similar JJ cord-010092-uftc8inx 2334 16 and and CC cord-010092-uftc8inx 2334 17 each each DT cord-010092-uftc8inx 2334 18 has have VBZ cord-010092-uftc8inx 2334 19 an an DT cord-010092-uftc8inx 2334 20 average average JJ cord-010092-uftc8inx 2334 21 ferritin ferritin NN cord-010092-uftc8inx 2334 22 level level NN cord-010092-uftc8inx 2334 23 of of IN cord-010092-uftc8inx 2334 24 43 43 CD cord-010092-uftc8inx 2334 25 ng ng NN cord-010092-uftc8inx 2334 26 / / SYM cord-010092-uftc8inx 2334 27 mL. ml. NN cord-010092-uftc8inx 2335 1 In in IN cord-010092-uftc8inx 2335 2 contrast contrast NN cord-010092-uftc8inx 2335 3 , , , cord-010092-uftc8inx 2335 4 we -PRON- PRP cord-010092-uftc8inx 2335 5 found find VBD cord-010092-uftc8inx 2335 6 that that IN cord-010092-uftc8inx 2335 7 only only RB cord-010092-uftc8inx 2335 8 27 27 CD cord-010092-uftc8inx 2335 9 % % NN cord-010092-uftc8inx 2335 10 of of IN cord-010092-uftc8inx 2335 11 new new JJ cord-010092-uftc8inx 2335 12 female female JJ cord-010092-uftc8inx 2335 13 donors donor NNS cord-010092-uftc8inx 2335 14 ( ( -LRB- cord-010092-uftc8inx 2335 15 n n NN cord-010092-uftc8inx 2335 16 = = SYM cord-010092-uftc8inx 2335 17 13,283 13,283 CD cord-010092-uftc8inx 2335 18 ) ) -RRB- cord-010092-uftc8inx 2335 19 and and CC cord-010092-uftc8inx 2335 20 1.7 1.7 CD cord-010092-uftc8inx 2335 21 % % NN cord-010092-uftc8inx 2335 22 of of IN cord-010092-uftc8inx 2335 23 new new JJ cord-010092-uftc8inx 2335 24 male male JJ cord-010092-uftc8inx 2335 25 donors donor NNS cord-010092-uftc8inx 2335 26 ( ( -LRB- cord-010092-uftc8inx 2335 27 n n NN cord-010092-uftc8inx 2335 28 = = SYM cord-010092-uftc8inx 2335 29 6,334 6,334 CD cord-010092-uftc8inx 2335 30 ) ) -RRB- cord-010092-uftc8inx 2335 31 have have VBP cord-010092-uftc8inx 2335 32 a a DT cord-010092-uftc8inx 2335 33 ferritin ferritin NN cord-010092-uftc8inx 2335 34 levels level NNS cord-010092-uftc8inx 2335 35 below below IN cord-010092-uftc8inx 2335 36 30 30 CD cord-010092-uftc8inx 2335 37 ng ng NN cord-010092-uftc8inx 2335 38 / / SYM cord-010092-uftc8inx 2335 39 mL. ml. NN cord-010092-uftc8inx 2336 1 The the DT cord-010092-uftc8inx 2336 2 average average JJ cord-010092-uftc8inx 2336 3 ferritin ferritin NN cord-010092-uftc8inx 2336 4 level level NN cord-010092-uftc8inx 2336 5 in in IN cord-010092-uftc8inx 2336 6 new new JJ cord-010092-uftc8inx 2336 7 donors donor NNS cord-010092-uftc8inx 2336 8 was be VBD cord-010092-uftc8inx 2336 9 148 148 CD cord-010092-uftc8inx 2336 10 ng ng NN cord-010092-uftc8inx 2336 11 / / SYM cord-010092-uftc8inx 2336 12 mL ml NN cord-010092-uftc8inx 2336 13 for for IN cord-010092-uftc8inx 2336 14 males male NNS cord-010092-uftc8inx 2336 15 and and CC cord-010092-uftc8inx 2336 16 60 60 CD cord-010092-uftc8inx 2336 17 ng ng NN cord-010092-uftc8inx 2336 18 / / SYM cord-010092-uftc8inx 2336 19 mL ml NN cord-010092-uftc8inx 2336 20 for for IN cord-010092-uftc8inx 2336 21 females female NNS cord-010092-uftc8inx 2336 22 . . . cord-010092-uftc8inx 2337 1 Comparing compare VBG cord-010092-uftc8inx 2337 2 the the DT cord-010092-uftc8inx 2337 3 ferritin ferritin NN cord-010092-uftc8inx 2337 4 levels level NNS cord-010092-uftc8inx 2337 5 in in IN cord-010092-uftc8inx 2337 6 new new JJ cord-010092-uftc8inx 2337 7 and and CC cord-010092-uftc8inx 2337 8 repeat repeat VB cord-010092-uftc8inx 2337 9 donors donor NNS cord-010092-uftc8inx 2337 10 , , , cord-010092-uftc8inx 2337 11 a a DT cord-010092-uftc8inx 2337 12 reduction reduction NN cord-010092-uftc8inx 2337 13 in in IN cord-010092-uftc8inx 2337 14 average average JJ cord-010092-uftc8inx 2337 15 ferritin ferritin NN cord-010092-uftc8inx 2337 16 levels level NNS cord-010092-uftc8inx 2337 17 between between IN cord-010092-uftc8inx 2337 18 1.5 1.5 CD cord-010092-uftc8inx 2337 19 and and CC cord-010092-uftc8inx 2337 20 2.0 2.0 CD cord-010092-uftc8inx 2337 21 was be VBD cord-010092-uftc8inx 2337 22 observed observe VBN cord-010092-uftc8inx 2337 23 in in IN cord-010092-uftc8inx 2337 24 female female JJ cord-010092-uftc8inx 2337 25 donors donor NNS cord-010092-uftc8inx 2337 26 and and CC cord-010092-uftc8inx 2337 27 between between IN cord-010092-uftc8inx 2337 28 3.2 3.2 CD cord-010092-uftc8inx 2337 29 and and CC cord-010092-uftc8inx 2337 30 4.4 4.4 CD cord-010092-uftc8inx 2337 31 in in IN cord-010092-uftc8inx 2337 32 male male JJ cord-010092-uftc8inx 2337 33 donors donor NNS cord-010092-uftc8inx 2337 34 . . . cord-010092-uftc8inx 2338 1 Both both DT cord-010092-uftc8inx 2338 2 ratios ratio NNS cord-010092-uftc8inx 2338 3 increased increase VBD cord-010092-uftc8inx 2338 4 with with IN cord-010092-uftc8inx 2338 5 donor donor NN cord-010092-uftc8inx 2338 6 age age NN cord-010092-uftc8inx 2338 7 . . . cord-010092-uftc8inx 2339 1 At at IN cord-010092-uftc8inx 2339 2 the the DT cord-010092-uftc8inx 2339 3 end end NN cord-010092-uftc8inx 2339 4 of of IN cord-010092-uftc8inx 2339 5 December December NNP cord-010092-uftc8inx 2339 6 2018 2018 CD cord-010092-uftc8inx 2339 7 2884 2884 CD cord-010092-uftc8inx 2339 8 donors donor NNS cord-010092-uftc8inx 2339 9 with with IN cord-010092-uftc8inx 2339 10 low low JJ cord-010092-uftc8inx 2339 11 ferritin ferritin NN cord-010092-uftc8inx 2339 12 levels level NNS cord-010092-uftc8inx 2339 13 returned return VBD cord-010092-uftc8inx 2339 14 for for IN cord-010092-uftc8inx 2339 15 donation donation NN cord-010092-uftc8inx 2339 16 after after IN cord-010092-uftc8inx 2339 17 six six CD cord-010092-uftc8inx 2339 18 or or CC cord-010092-uftc8inx 2339 19 twelve twelve CD cord-010092-uftc8inx 2339 20 months month NNS cord-010092-uftc8inx 2339 21 deferral deferral NN cord-010092-uftc8inx 2339 22 . . . cord-010092-uftc8inx 2340 1 Repeat repeat VB cord-010092-uftc8inx 2340 2 ferritin ferritin NN cord-010092-uftc8inx 2340 3 measurements measurement NNS cord-010092-uftc8inx 2340 4 show show VBP cord-010092-uftc8inx 2340 5 that that IN cord-010092-uftc8inx 2340 6 on on IN cord-010092-uftc8inx 2340 7 average average JJ cord-010092-uftc8inx 2340 8 the the DT cord-010092-uftc8inx 2340 9 ferritin ferritin NN cord-010092-uftc8inx 2340 10 levels level NNS cord-010092-uftc8inx 2340 11 in in IN cord-010092-uftc8inx 2340 12 female female JJ cord-010092-uftc8inx 2340 13 donors donor NNS cord-010092-uftc8inx 2340 14 increased increase VBD cord-010092-uftc8inx 2340 15 by by IN cord-010092-uftc8inx 2340 16 13 13 CD cord-010092-uftc8inx 2340 17 ng ng NN cord-010092-uftc8inx 2340 18 / / SYM cord-010092-uftc8inx 2340 19 mL ml NN cord-010092-uftc8inx 2340 20 per per IN cord-010092-uftc8inx 2340 21 year year NN cord-010092-uftc8inx 2340 22 whereas whereas IN cord-010092-uftc8inx 2340 23 average average JJ cord-010092-uftc8inx 2340 24 ferritin ferritin NN cord-010092-uftc8inx 2340 25 levels level NNS cord-010092-uftc8inx 2340 26 in in IN cord-010092-uftc8inx 2340 27 male male JJ cord-010092-uftc8inx 2340 28 donors donor NNS cord-010092-uftc8inx 2340 29 increased increase VBD cord-010092-uftc8inx 2340 30 by by IN cord-010092-uftc8inx 2340 31 34 34 CD cord-010092-uftc8inx 2340 32 ng ng NN cord-010092-uftc8inx 2340 33 / / SYM cord-010092-uftc8inx 2340 34 mL ml NN cord-010092-uftc8inx 2340 35 per per IN cord-010092-uftc8inx 2340 36 year year NN cord-010092-uftc8inx 2340 37 . . . cord-010092-uftc8inx 2341 1 Summary Summary NNP cord-010092-uftc8inx 2341 2 / / SYM cord-010092-uftc8inx 2341 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 2341 4 : : : cord-010092-uftc8inx 2342 1 In in IN cord-010092-uftc8inx 2342 2 line line NN cord-010092-uftc8inx 2342 3 with with IN cord-010092-uftc8inx 2342 4 earlier early JJR cord-010092-uftc8inx 2342 5 findings finding NNS cord-010092-uftc8inx 2342 6 in in IN cord-010092-uftc8inx 2342 7 literature literature NN cord-010092-uftc8inx 2342 8 our -PRON- PRP$ cord-010092-uftc8inx 2342 9 results result NNS cord-010092-uftc8inx 2342 10 show show VBP cord-010092-uftc8inx 2342 11 that that IN cord-010092-uftc8inx 2342 12 repeat repeat VBP cord-010092-uftc8inx 2342 13 donations donation NNS cord-010092-uftc8inx 2342 14 substantially substantially RB cord-010092-uftc8inx 2342 15 reduce reduce VBP cord-010092-uftc8inx 2342 16 ferritin ferritin NN cord-010092-uftc8inx 2342 17 levels level NNS cord-010092-uftc8inx 2342 18 in in IN cord-010092-uftc8inx 2342 19 repeat repeat NN cord-010092-uftc8inx 2342 20 donors donor NNS cord-010092-uftc8inx 2342 21 . . . cord-010092-uftc8inx 2343 1 These these DT cord-010092-uftc8inx 2343 2 range range VBP cord-010092-uftc8inx 2343 3 from from IN cord-010092-uftc8inx 2343 4 1.5 1.5 CD cord-010092-uftc8inx 2343 5 to to IN cord-010092-uftc8inx 2343 6 2.0 2.0 CD cord-010092-uftc8inx 2343 7 in in IN cord-010092-uftc8inx 2343 8 female female NN cord-010092-uftc8inx 2343 9 and and CC cord-010092-uftc8inx 2343 10 from from IN cord-010092-uftc8inx 2343 11 3.2 3.2 CD cord-010092-uftc8inx 2343 12 to to IN cord-010092-uftc8inx 2343 13 4.4 4.4 CD cord-010092-uftc8inx 2343 14 in in IN cord-010092-uftc8inx 2343 15 male male JJ cord-010092-uftc8inx 2343 16 donors donor NNS cord-010092-uftc8inx 2343 17 , , , cord-010092-uftc8inx 2343 18 who who WP cord-010092-uftc8inx 2343 19 generally generally RB cord-010092-uftc8inx 2343 20 have have VBP cord-010092-uftc8inx 2343 21 higher high JJR cord-010092-uftc8inx 2343 22 ferritin ferritin NN cord-010092-uftc8inx 2343 23 levels level NNS cord-010092-uftc8inx 2343 24 . . . cord-010092-uftc8inx 2344 1 Deferral deferral NN cord-010092-uftc8inx 2344 2 of of IN cord-010092-uftc8inx 2344 3 donors donor NNS cord-010092-uftc8inx 2344 4 with with IN cord-010092-uftc8inx 2344 5 low low JJ cord-010092-uftc8inx 2344 6 ferritin ferritin NN cord-010092-uftc8inx 2344 7 levels level NNS cord-010092-uftc8inx 2344 8 seems seem VBZ cord-010092-uftc8inx 2344 9 to to TO cord-010092-uftc8inx 2344 10 be be VB cord-010092-uftc8inx 2344 11 effective effective JJ cord-010092-uftc8inx 2344 12 in in IN cord-010092-uftc8inx 2344 13 increasing increase VBG cord-010092-uftc8inx 2344 14 ferritin ferritin NN cord-010092-uftc8inx 2344 15 levels level NNS cord-010092-uftc8inx 2344 16 in in IN cord-010092-uftc8inx 2344 17 donors donor NNS cord-010092-uftc8inx 2344 18 , , , cord-010092-uftc8inx 2344 19 however however RB cord-010092-uftc8inx 2344 20 , , , cord-010092-uftc8inx 2344 21 further further RB cord-010092-uftc8inx 2344 22 monitoring monitoring NN cord-010092-uftc8inx 2344 23 of of IN cord-010092-uftc8inx 2344 24 follow follow NN cord-010092-uftc8inx 2344 25 - - HYPH cord-010092-uftc8inx 2344 26 up up NN cord-010092-uftc8inx 2344 27 in in IN cord-010092-uftc8inx 2344 28 repeat repeat NN cord-010092-uftc8inx 2344 29 donors donor NNS cord-010092-uftc8inx 2344 30 is be VBZ cord-010092-uftc8inx 2344 31 warranted warrant VBN cord-010092-uftc8inx 2344 32 to to TO cord-010092-uftc8inx 2344 33 see see VB cord-010092-uftc8inx 2344 34 whether whether IN cord-010092-uftc8inx 2344 35 the the DT cord-010092-uftc8inx 2344 36 proposed propose VBN cord-010092-uftc8inx 2344 37 scheme scheme NN cord-010092-uftc8inx 2344 38 allows allow VBZ cord-010092-uftc8inx 2344 39 for for IN cord-010092-uftc8inx 2344 40 sufficient sufficient JJ cord-010092-uftc8inx 2344 41 donor donor NN cord-010092-uftc8inx 2344 42 recovery recovery NN cord-010092-uftc8inx 2344 43 over over IN cord-010092-uftc8inx 2344 44 time time NN cord-010092-uftc8inx 2344 45 . . . cord-010092-uftc8inx 2345 1 There there RB cord-010092-uftc8inx 2345 2 are~7000 are~7000 NNP cord-010092-uftc8inx 2345 3 different different JJ cord-010092-uftc8inx 2345 4 rare rare JJ cord-010092-uftc8inx 2345 5 diseases disease NNS cord-010092-uftc8inx 2345 6 and and CC cord-010092-uftc8inx 2345 7 the the DT cord-010092-uftc8inx 2345 8 genes gene NNS cord-010092-uftc8inx 2345 9 for for IN cord-010092-uftc8inx 2345 10 half half NN cord-010092-uftc8inx 2345 11 have have VBP cord-010092-uftc8inx 2345 12 been be VBN cord-010092-uftc8inx 2345 13 identified identify VBN cord-010092-uftc8inx 2345 14 . . . cord-010092-uftc8inx 2346 1 Approximately approximately RB cord-010092-uftc8inx 2346 2 3.5 3.5 CD cord-010092-uftc8inx 2346 3 million million CD cord-010092-uftc8inx 2346 4 UK UK NNP cord-010092-uftc8inx 2346 5 citizens citizen NNS cord-010092-uftc8inx 2346 6 experience experience VBP cord-010092-uftc8inx 2346 7 premature premature JJ cord-010092-uftc8inx 2346 8 ill ill JJ cord-010092-uftc8inx 2346 9 - - HYPH cord-010092-uftc8inx 2346 10 health health NN cord-010092-uftc8inx 2346 11 because because IN cord-010092-uftc8inx 2346 12 of of IN cord-010092-uftc8inx 2346 13 a a DT cord-010092-uftc8inx 2346 14 rare rare JJ cord-010092-uftc8inx 2346 15 disease disease NN cord-010092-uftc8inx 2346 16 . . . cord-010092-uftc8inx 2347 1 A a DT cord-010092-uftc8inx 2347 2 conclusive conclusive JJ cord-010092-uftc8inx 2347 3 diagnosis diagnosis NN cord-010092-uftc8inx 2347 4 is be VBZ cord-010092-uftc8inx 2347 5 generally generally RB cord-010092-uftc8inx 2347 6 not not RB cord-010092-uftc8inx 2347 7 reached reach VBN cord-010092-uftc8inx 2347 8 and and CC cord-010092-uftc8inx 2347 9 on on IN cord-010092-uftc8inx 2347 10 average average JJ cord-010092-uftc8inx 2347 11 the the DT cord-010092-uftc8inx 2347 12 diagnostic diagnostic JJ cord-010092-uftc8inx 2347 13 odyssey odyssey NN cord-010092-uftc8inx 2347 14 lasts last VBZ cord-010092-uftc8inx 2347 15 2.2 2.2 CD cord-010092-uftc8inx 2347 16 years year NNS cord-010092-uftc8inx 2347 17 . . . cord-010092-uftc8inx 2348 1 The the DT cord-010092-uftc8inx 2348 2 main main JJ cord-010092-uftc8inx 2348 3 aims aim NNS cord-010092-uftc8inx 2348 4 of of IN cord-010092-uftc8inx 2348 5 the the DT cord-010092-uftc8inx 2348 6 100,000 100,000 CD cord-010092-uftc8inx 2348 7 Genomes Genomes NNPS cord-010092-uftc8inx 2348 8 Project Project NNP cord-010092-uftc8inx 2348 9 are be VBP cord-010092-uftc8inx 2348 10 to to TO cord-010092-uftc8inx 2348 11 reduce reduce VB cord-010092-uftc8inx 2348 12 the the DT cord-010092-uftc8inx 2348 13 diagnostic diagnostic JJ cord-010092-uftc8inx 2348 14 delay delay NN cord-010092-uftc8inx 2348 15 by by IN cord-010092-uftc8inx 2348 16 embedding embed VBG cord-010092-uftc8inx 2348 17 whole whole JJ cord-010092-uftc8inx 2348 18 genome genome NN cord-010092-uftc8inx 2348 19 sequencing sequencing NN cord-010092-uftc8inx 2348 20 ( ( -LRB- cord-010092-uftc8inx 2348 21 WGS WGS NNP cord-010092-uftc8inx 2348 22 ) ) -RRB- cord-010092-uftc8inx 2348 23 to to IN cord-010092-uftc8inx 2348 24 accredited accredit VBN cord-010092-uftc8inx 2348 25 standards standard NNS cord-010092-uftc8inx 2348 26 in in IN cord-010092-uftc8inx 2348 27 the the DT cord-010092-uftc8inx 2348 28 care care NN cord-010092-uftc8inx 2348 29 path path NN cord-010092-uftc8inx 2348 30 of of IN cord-010092-uftc8inx 2348 31 patients patient NNS cord-010092-uftc8inx 2348 32 with with IN cord-010092-uftc8inx 2348 33 undiagnosed undiagnosed JJ cord-010092-uftc8inx 2348 34 rare rare JJ cord-010092-uftc8inx 2348 35 diseases disease NNS cord-010092-uftc8inx 2348 36 . . . cord-010092-uftc8inx 2349 1 The the DT cord-010092-uftc8inx 2349 2 project project NN cord-010092-uftc8inx 2349 3 started start VBD cord-010092-uftc8inx 2349 4 in in IN cord-010092-uftc8inx 2349 5 2013 2013 CD cord-010092-uftc8inx 2349 6 and and CC cord-010092-uftc8inx 2349 7 DNA dna NN cord-010092-uftc8inx 2349 8 samples sample NNS cord-010092-uftc8inx 2349 9 from from IN cord-010092-uftc8inx 2349 10 100,000 100,000 CD cord-010092-uftc8inx 2349 11 NHS NHS NNP cord-010092-uftc8inx 2349 12 patients patient NNS cord-010092-uftc8inx 2349 13 and and CC cord-010092-uftc8inx 2349 14 their -PRON- PRP$ cord-010092-uftc8inx 2349 15 close close JJ cord-010092-uftc8inx 2349 16 relatives relative NNS cord-010092-uftc8inx 2349 17 have have VBP cord-010092-uftc8inx 2349 18 been be VBN cord-010092-uftc8inx 2349 19 analysed analyse VBN cord-010092-uftc8inx 2349 20 by by IN cord-010092-uftc8inx 2349 21 WGS WGS NNP cord-010092-uftc8inx 2349 22 . . . cord-010092-uftc8inx 2350 1 Here here RB cord-010092-uftc8inx 2350 2 we -PRON- PRP cord-010092-uftc8inx 2350 3 review review VBP cord-010092-uftc8inx 2350 4 the the DT cord-010092-uftc8inx 2350 5 results result NNS cord-010092-uftc8inx 2350 6 from from IN cord-010092-uftc8inx 2350 7 the the DT cord-010092-uftc8inx 2350 8 NIHR NIHR NNP cord-010092-uftc8inx 2350 9 BioResource BioResource NNP cord-010092-uftc8inx 2350 10 pilot pilot NN cord-010092-uftc8inx 2350 11 study study NN cord-010092-uftc8inx 2350 12 for for IN cord-010092-uftc8inx 2350 13 the the DT cord-010092-uftc8inx 2350 14 100,000 100,000 CD cord-010092-uftc8inx 2350 15 Genomes Genomes NNPS cord-010092-uftc8inx 2350 16 Project Project NNP cord-010092-uftc8inx 2350 17 comprising comprise VBG cord-010092-uftc8inx 2350 18 phenotype phenotype NN cord-010092-uftc8inx 2350 19 and and CC cord-010092-uftc8inx 2350 20 genotype genotype NN cord-010092-uftc8inx 2350 21 data datum NNS cord-010092-uftc8inx 2350 22 from from IN cord-010092-uftc8inx 2350 23 13,037 13,037 CD cord-010092-uftc8inx 2350 24 individuals individual NNS cord-010092-uftc8inx 2350 25 recruited recruit VBN cord-010092-uftc8inx 2350 26 at at IN cord-010092-uftc8inx 2350 27 83 83 CD cord-010092-uftc8inx 2350 28 hospitals hospital NNS cord-010092-uftc8inx 2350 29 using use VBG cord-010092-uftc8inx 2350 30 approved approve VBN cord-010092-uftc8inx 2350 31 eligibility eligibility NN cord-010092-uftc8inx 2350 32 criteria criterion NNS cord-010092-uftc8inx 2350 33 for for IN cord-010092-uftc8inx 2350 34 15 15 CD cord-010092-uftc8inx 2350 35 rare rare JJ cord-010092-uftc8inx 2350 36 disease disease NN cord-010092-uftc8inx 2350 37 domains domain NNS cord-010092-uftc8inx 2350 38 . . . cord-010092-uftc8inx 2351 1 We -PRON- PRP cord-010092-uftc8inx 2351 2 determined determine VBD cord-010092-uftc8inx 2351 3 the the DT cord-010092-uftc8inx 2351 4 population population NN cord-010092-uftc8inx 2351 5 structure structure NN cord-010092-uftc8inx 2351 6 including include VBG cord-010092-uftc8inx 2351 7 ethnicity ethnicity NN cord-010092-uftc8inx 2351 8 and and CC cord-010092-uftc8inx 2351 9 relatedness relatedness NN cord-010092-uftc8inx 2351 10 estimation estimation NN cord-010092-uftc8inx 2351 11 , , , cord-010092-uftc8inx 2351 12 high high JJ cord-010092-uftc8inx 2351 13 level level NN cord-010092-uftc8inx 2351 14 phenotypes phenotype NNS cord-010092-uftc8inx 2351 15 collected collect VBN cord-010092-uftc8inx 2351 16 using use VBG cord-010092-uftc8inx 2351 17 Human Human NNP cord-010092-uftc8inx 2351 18 Phenotype Phenotype NNP cord-010092-uftc8inx 2351 19 Ontology Ontology NNP cord-010092-uftc8inx 2351 20 ( ( -LRB- cord-010092-uftc8inx 2351 21 HPO HPO NNP cord-010092-uftc8inx 2351 22 ) ) -RRB- cord-010092-uftc8inx 2351 23 terms term NNS cord-010092-uftc8inx 2351 24 and and CC cord-010092-uftc8inx 2351 25 quality quality NN cord-010092-uftc8inx 2351 26 control control NN cord-010092-uftc8inx 2351 27 and and CC cord-010092-uftc8inx 2351 28 summary summary NN cord-010092-uftc8inx 2351 29 metrics metric NNS cord-010092-uftc8inx 2351 30 for for IN cord-010092-uftc8inx 2351 31 samples sample NNS cord-010092-uftc8inx 2351 32 and and CC cord-010092-uftc8inx 2351 33 variants variant NNS cord-010092-uftc8inx 2351 34 . . . cord-010092-uftc8inx 2352 1 The the DT cord-010092-uftc8inx 2352 2 sequence sequence NN cord-010092-uftc8inx 2352 3 resource resource NN cord-010092-uftc8inx 2352 4 contains contain VBZ cord-010092-uftc8inx 2352 5 over over IN cord-010092-uftc8inx 2352 6 165 165 CD cord-010092-uftc8inx 2352 7 million million CD cord-010092-uftc8inx 2352 8 unique unique JJ cord-010092-uftc8inx 2352 9 variants variant NNS cord-010092-uftc8inx 2352 10 in in IN cord-010092-uftc8inx 2352 11 the the DT cord-010092-uftc8inx 2352 12 10,258 10,258 CD cord-010092-uftc8inx 2352 13 genetically genetically RB cord-010092-uftc8inx 2352 14 independent independent JJ cord-010092-uftc8inx 2352 15 samples sample NNS cord-010092-uftc8inx 2352 16 , , , cord-010092-uftc8inx 2352 17 with with IN cord-010092-uftc8inx 2352 18 47 47 CD cord-010092-uftc8inx 2352 19 % % NN cord-010092-uftc8inx 2352 20 of of IN cord-010092-uftc8inx 2352 21 variants variant NNS cord-010092-uftc8inx 2352 22 previously previously RB cord-010092-uftc8inx 2352 23 unobserved unobserved JJ cord-010092-uftc8inx 2352 24 in in IN cord-010092-uftc8inx 2352 25 other other JJ cord-010092-uftc8inx 2352 26 large large JJ cord-010092-uftc8inx 2352 27 scale scale NN cord-010092-uftc8inx 2352 28 publicly publicly RB cord-010092-uftc8inx 2352 29 available available JJ cord-010092-uftc8inx 2352 30 genome genome NN cord-010092-uftc8inx 2352 31 datasets dataset NNS cord-010092-uftc8inx 2352 32 . . . cord-010092-uftc8inx 2353 1 We -PRON- PRP cord-010092-uftc8inx 2353 2 summarise summarise VBP cord-010092-uftc8inx 2353 3 the the DT cord-010092-uftc8inx 2353 4 curation curation NN cord-010092-uftc8inx 2353 5 of of IN cord-010092-uftc8inx 2353 6 gene gene NN cord-010092-uftc8inx 2353 7 lists list NNS cord-010092-uftc8inx 2353 8 and and CC cord-010092-uftc8inx 2353 9 pertinent pertinent JJ cord-010092-uftc8inx 2353 10 findings finding NNS cord-010092-uftc8inx 2353 11 in in IN cord-010092-uftc8inx 2353 12 2,000 2,000 CD cord-010092-uftc8inx 2353 13 unique unique JJ cord-010092-uftc8inx 2353 14 diagnostic diagnostic JJ cord-010092-uftc8inx 2353 15 - - HYPH cord-010092-uftc8inx 2353 16 grade grade NN cord-010092-uftc8inx 2353 17 genes gene NNS cord-010092-uftc8inx 2353 18 for for IN cord-010092-uftc8inx 2353 19 the the DT cord-010092-uftc8inx 2353 20 15 15 CD cord-010092-uftc8inx 2353 21 domains domain NNS cord-010092-uftc8inx 2353 22 . . . cord-010092-uftc8inx 2354 1 Over over IN cord-010092-uftc8inx 2354 2 1,000 1,000 CD cord-010092-uftc8inx 2354 3 reports report NNS cord-010092-uftc8inx 2354 4 assigning assign VBG cord-010092-uftc8inx 2354 5 pathogenic pathogenic JJ cord-010092-uftc8inx 2354 6 or or CC cord-010092-uftc8inx 2354 7 likely likely JJ cord-010092-uftc8inx 2354 8 pathogenic pathogenic JJ cord-010092-uftc8inx 2354 9 causal causal JJ cord-010092-uftc8inx 2354 10 variants variant NNS cord-010092-uftc8inx 2354 11 have have VBP cord-010092-uftc8inx 2354 12 been be VBN cord-010092-uftc8inx 2354 13 issued issue VBN cord-010092-uftc8inx 2354 14 with with IN cord-010092-uftc8inx 2354 15 diagnostic diagnostic JJ cord-010092-uftc8inx 2354 16 yields yield NNS cord-010092-uftc8inx 2354 17 varying vary VBG cord-010092-uftc8inx 2354 18 between between IN cord-010092-uftc8inx 2354 19 domains domain NNS cord-010092-uftc8inx 2354 20 from from IN cord-010092-uftc8inx 2354 21 0.5 0.5 CD cord-010092-uftc8inx 2354 22 % % NN cord-010092-uftc8inx 2354 23 to to IN cord-010092-uftc8inx 2354 24 55 55 CD cord-010092-uftc8inx 2354 25 % % NN cord-010092-uftc8inx 2354 26 , , , cord-010092-uftc8inx 2354 27 while while IN cord-010092-uftc8inx 2354 28 the the DT cord-010092-uftc8inx 2354 29 proportion proportion NN cord-010092-uftc8inx 2354 30 of of IN cord-010092-uftc8inx 2354 31 novel novel JJ cord-010092-uftc8inx 2354 32 causal causal NN cord-010092-uftc8inx 2354 33 variants variant NNS cord-010092-uftc8inx 2354 34 ranged range VBD cord-010092-uftc8inx 2354 35 between between IN cord-010092-uftc8inx 2354 36 25 25 CD cord-010092-uftc8inx 2354 37 % % NN cord-010092-uftc8inx 2354 38 and and CC cord-010092-uftc8inx 2354 39 73 73 CD cord-010092-uftc8inx 2354 40 % % NN cord-010092-uftc8inx 2354 41 . . . cord-010092-uftc8inx 2355 1 We -PRON- PRP cord-010092-uftc8inx 2355 2 show show VBP cord-010092-uftc8inx 2355 3 the the DT cord-010092-uftc8inx 2355 4 power power NN cord-010092-uftc8inx 2355 5 of of IN cord-010092-uftc8inx 2355 6 the the DT cord-010092-uftc8inx 2355 7 Bayesian Bayesian NNP cord-010092-uftc8inx 2355 8 association association NN cord-010092-uftc8inx 2355 9 test test NN cord-010092-uftc8inx 2355 10 , , , cord-010092-uftc8inx 2355 11 BeviMed BeviMed NNP cord-010092-uftc8inx 2355 12 , , , cord-010092-uftc8inx 2355 13 to to TO cord-010092-uftc8inx 2355 14 recapitulate recapitulate VB cord-010092-uftc8inx 2355 15 decades decade NNS cord-010092-uftc8inx 2355 16 of of IN cord-010092-uftc8inx 2355 17 clinical clinical JJ cord-010092-uftc8inx 2355 18 genetics genetics NN cord-010092-uftc8inx 2355 19 discoveries discovery NNS cord-010092-uftc8inx 2355 20 and and CC cord-010092-uftc8inx 2355 21 by by IN cord-010092-uftc8inx 2355 22 identifying identify VBG cord-010092-uftc8inx 2355 23 > > SYM cord-010092-uftc8inx 2355 24 30 30 CD cord-010092-uftc8inx 2355 25 novel novel JJ cord-010092-uftc8inx 2355 26 genes gene NNS cord-010092-uftc8inx 2355 27 and and CC cord-010092-uftc8inx 2355 28 novel novel NN cord-010092-uftc8inx 2355 29 diseasecausing diseasecausing NN cord-010092-uftc8inx 2355 30 variants variant NNS cord-010092-uftc8inx 2355 31 in in IN cord-010092-uftc8inx 2355 32 the the DT cord-010092-uftc8inx 2355 33 non non JJ cord-010092-uftc8inx 2355 34 - - JJ cord-010092-uftc8inx 2355 35 coding coding JJ cord-010092-uftc8inx 2355 36 space space NN cord-010092-uftc8inx 2355 37 of of IN cord-010092-uftc8inx 2355 38 the the DT cord-010092-uftc8inx 2355 39 genome genome NN cord-010092-uftc8inx 2355 40 . . . cord-010092-uftc8inx 2356 1 We -PRON- PRP cord-010092-uftc8inx 2356 2 show show VBP cord-010092-uftc8inx 2356 3 how how WRB cord-010092-uftc8inx 2356 4 typing type VBG cord-010092-uftc8inx 2356 5 data datum NNS cord-010092-uftc8inx 2356 6 for for IN cord-010092-uftc8inx 2356 7 all all DT cord-010092-uftc8inx 2356 8 red red JJ cord-010092-uftc8inx 2356 9 cell cell NN cord-010092-uftc8inx 2356 10 , , , cord-010092-uftc8inx 2356 11 HPA HPA NNP cord-010092-uftc8inx 2356 12 and and CC cord-010092-uftc8inx 2356 13 HLA HLA NNP cord-010092-uftc8inx 2356 14 class class NN cord-010092-uftc8inx 2356 15 antigens antigen NNS cord-010092-uftc8inx 2356 16 can can MD cord-010092-uftc8inx 2356 17 be be VB cord-010092-uftc8inx 2356 18 extracted extract VBN cord-010092-uftc8inx 2356 19 from from IN cord-010092-uftc8inx 2356 20 WGS WGS NNP cord-010092-uftc8inx 2356 21 data datum NNS cord-010092-uftc8inx 2356 22 . . . cord-010092-uftc8inx 2357 1 We -PRON- PRP cord-010092-uftc8inx 2357 2 mined mine VBD cord-010092-uftc8inx 2357 3 the the DT cord-010092-uftc8inx 2357 4 data datum NNS cord-010092-uftc8inx 2357 5 from from IN cord-010092-uftc8inx 2357 6 the the DT cord-010092-uftc8inx 2357 7 100,000 100,000 CD cord-010092-uftc8inx 2357 8 Genomes Genomes NNPS cord-010092-uftc8inx 2357 9 Project Project NNP cord-010092-uftc8inx 2357 10 and and CC cord-010092-uftc8inx 2357 11 similar similar JJ cord-010092-uftc8inx 2357 12 sequence sequence NN cord-010092-uftc8inx 2357 13 resources resource NNS cord-010092-uftc8inx 2357 14 to to TO cord-010092-uftc8inx 2357 15 re re VB cord-010092-uftc8inx 2357 16 - - VB cord-010092-uftc8inx 2357 17 version version VB cord-010092-uftc8inx 2357 18 the the DT cord-010092-uftc8inx 2357 19 probe probe NN cord-010092-uftc8inx 2357 20 content content NN cord-010092-uftc8inx 2357 21 of of IN cord-010092-uftc8inx 2357 22 the the DT cord-010092-uftc8inx 2357 23 UK UK NNP cord-010092-uftc8inx 2357 24 Biobank Biobank NNP cord-010092-uftc8inx 2357 25 Axiom Axiom NNP cord-010092-uftc8inx 2357 26 array array NN cord-010092-uftc8inx 2357 27 . . . cord-010092-uftc8inx 2358 1 We -PRON- PRP cord-010092-uftc8inx 2358 2 genotyped genotype VBD cord-010092-uftc8inx 2358 3 7588 7588 CD cord-010092-uftc8inx 2358 4 donors donor NNS cord-010092-uftc8inx 2358 5 from from IN cord-010092-uftc8inx 2358 6 England England NNP cord-010092-uftc8inx 2358 7 and and CC cord-010092-uftc8inx 2358 8 the the DT cord-010092-uftc8inx 2358 9 Netherlands Netherlands NNP cord-010092-uftc8inx 2358 10 with with IN cord-010092-uftc8inx 2358 11 this this DT cord-010092-uftc8inx 2358 12 new new JJ cord-010092-uftc8inx 2358 13 array array NN cord-010092-uftc8inx 2358 14 and and CC cord-010092-uftc8inx 2358 15 observed observe VBD cord-010092-uftc8inx 2358 16 a a DT cord-010092-uftc8inx 2358 17 99.92 99.92 CD cord-010092-uftc8inx 2358 18 % % NN cord-010092-uftc8inx 2358 19 concordance concordance NN cord-010092-uftc8inx 2358 20 when when WRB cord-010092-uftc8inx 2358 21 comparing compare VBG cord-010092-uftc8inx 2358 22 92,387 92,387 CD cord-010092-uftc8inx 2358 23 blood blood NN cord-010092-uftc8inx 2358 24 centredetermined centredetermine VBN cord-010092-uftc8inx 2358 25 antigen antigen NN cord-010092-uftc8inx 2358 26 typing typing NN cord-010092-uftc8inx 2358 27 results result NNS cord-010092-uftc8inx 2358 28 with with IN cord-010092-uftc8inx 2358 29 genotype genotype NN cord-010092-uftc8inx 2358 30 - - HYPH cord-010092-uftc8inx 2358 31 determined determine VBN cord-010092-uftc8inx 2358 32 ones one NNS cord-010092-uftc8inx 2358 33 . . . cord-010092-uftc8inx 2359 1 For for IN cord-010092-uftc8inx 2359 2 the the DT cord-010092-uftc8inx 2359 3 48 48 CD cord-010092-uftc8inx 2359 4 red red JJ cord-010092-uftc8inx 2359 5 cell cell NN cord-010092-uftc8inx 2359 6 and and CC cord-010092-uftc8inx 2359 7 HPA HPA NNP cord-010092-uftc8inx 2359 8 antigens antigen NNS cord-010092-uftc8inx 2359 9 that that WDT cord-010092-uftc8inx 2359 10 were be VBD cord-010092-uftc8inx 2359 11 available available JJ cord-010092-uftc8inx 2359 12 for for IN cord-010092-uftc8inx 2359 13 7,473 7,473 CD cord-010092-uftc8inx 2359 14 donors donor NNS cord-010092-uftc8inx 2359 15 , , , cord-010092-uftc8inx 2359 16 the the DT cord-010092-uftc8inx 2359 17 array array NN cord-010092-uftc8inx 2359 18 typing typing NN cord-010092-uftc8inx 2359 19 provided provide VBD cord-010092-uftc8inx 2359 20 a a DT cord-010092-uftc8inx 2359 21 3.6-fold 3.6-fold CD cord-010092-uftc8inx 2359 22 increase increase NN cord-010092-uftc8inx 2359 23 in in IN cord-010092-uftc8inx 2359 24 typing type VBG cord-010092-uftc8inx 2359 25 results result NNS cord-010092-uftc8inx 2359 26 per per IN cord-010092-uftc8inx 2359 27 donor donor NN cord-010092-uftc8inx 2359 28 ( ( -LRB- cord-010092-uftc8inx 2359 29 13.2 13.2 CD cord-010092-uftc8inx 2359 30 vs vs IN cord-010092-uftc8inx 2359 31 47.9 47.9 CD cord-010092-uftc8inx 2359 32 ) ) -RRB- cord-010092-uftc8inx 2359 33 and and CC cord-010092-uftc8inx 2359 34 38 38 CD cord-010092-uftc8inx 2359 35 rare rare JJ cord-010092-uftc8inx 2359 36 donors donor NNS cord-010092-uftc8inx 2359 37 were be VBD cord-010092-uftc8inx 2359 38 identified identify VBN cord-010092-uftc8inx 2359 39 . . . cord-010092-uftc8inx 2360 1 Using use VBG cord-010092-uftc8inx 2360 2 the the DT cord-010092-uftc8inx 2360 3 genotyping genotyping NN cord-010092-uftc8inx 2360 4 data datum NNS cord-010092-uftc8inx 2360 5 we -PRON- PRP cord-010092-uftc8inx 2360 6 identified identify VBD cord-010092-uftc8inx 2360 7 2.6 2.6 CD cord-010092-uftc8inx 2360 8 times time NNS cord-010092-uftc8inx 2360 9 more more RBR cord-010092-uftc8inx 2360 10 compatible compatible JJ cord-010092-uftc8inx 2360 11 units unit NNS cord-010092-uftc8inx 2360 12 among among IN cord-010092-uftc8inx 2360 13 this this DT cord-010092-uftc8inx 2360 14 cohort cohort NN cord-010092-uftc8inx 2360 15 of of IN cord-010092-uftc8inx 2360 16 donors donor NNS cord-010092-uftc8inx 2360 17 when when WRB cord-010092-uftc8inx 2360 18 blood blood NN cord-010092-uftc8inx 2360 19 demand demand NN cord-010092-uftc8inx 2360 20 was be VBD cord-010092-uftc8inx 2360 21 modelled model VBN cord-010092-uftc8inx 2360 22 using use VBG cord-010092-uftc8inx 2360 23 referral referral JJ cord-010092-uftc8inx 2360 24 data datum NNS cord-010092-uftc8inx 2360 25 from from IN cord-010092-uftc8inx 2360 26 3,146 3,146 CD cord-010092-uftc8inx 2360 27 English english JJ cord-010092-uftc8inx 2360 28 patients patient NNS cord-010092-uftc8inx 2360 29 with with IN cord-010092-uftc8inx 2360 30 more more JJR cord-010092-uftc8inx 2360 31 than than IN cord-010092-uftc8inx 2360 32 three three CD cord-010092-uftc8inx 2360 33 red red JJ cord-010092-uftc8inx 2360 34 cell cell NN cord-010092-uftc8inx 2360 35 alloantibodies alloantibody NNS cord-010092-uftc8inx 2360 36 . . . cord-010092-uftc8inx 2361 1 In in IN cord-010092-uftc8inx 2361 2 conclusion conclusion NN cord-010092-uftc8inx 2361 3 the the DT cord-010092-uftc8inx 2361 4 100,000 100,000 CD cord-010092-uftc8inx 2361 5 Genomes Genomes NNPS cord-010092-uftc8inx 2361 6 Project Project NNP cord-010092-uftc8inx 2361 7 has have VBZ cord-010092-uftc8inx 2361 8 shown show VBN cord-010092-uftc8inx 2361 9 the the DT cord-010092-uftc8inx 2361 10 feasibility feasibility NN cord-010092-uftc8inx 2361 11 of of IN cord-010092-uftc8inx 2361 12 using use VBG cord-010092-uftc8inx 2361 13 WGS WGS NNP cord-010092-uftc8inx 2361 14 across across IN cord-010092-uftc8inx 2361 15 a a DT cord-010092-uftc8inx 2361 16 universal universal JJ cord-010092-uftc8inx 2361 17 healthcare healthcare NN cord-010092-uftc8inx 2361 18 system system NN cord-010092-uftc8inx 2361 19 to to TO cord-010092-uftc8inx 2361 20 deliver deliver VB cord-010092-uftc8inx 2361 21 a a DT cord-010092-uftc8inx 2361 22 diagnosis diagnosis NN cord-010092-uftc8inx 2361 23 for for IN cord-010092-uftc8inx 2361 24 patients patient NNS cord-010092-uftc8inx 2361 25 with with IN cord-010092-uftc8inx 2361 26 rare rare JJ cord-010092-uftc8inx 2361 27 diseases disease NNS cord-010092-uftc8inx 2361 28 . . . cord-010092-uftc8inx 2362 1 Based base VBN cord-010092-uftc8inx 2362 2 on on IN cord-010092-uftc8inx 2362 3 these these DT cord-010092-uftc8inx 2362 4 results result NNS cord-010092-uftc8inx 2362 5 the the DT cord-010092-uftc8inx 2362 6 NHS NHS NNP cord-010092-uftc8inx 2362 7 has have VBZ cord-010092-uftc8inx 2362 8 commissioned commission VBN cord-010092-uftc8inx 2362 9 the the DT cord-010092-uftc8inx 2362 10 analysis analysis NN cord-010092-uftc8inx 2362 11 of of IN cord-010092-uftc8inx 2362 12 another another DT cord-010092-uftc8inx 2362 13 500,000 500,000 CD cord-010092-uftc8inx 2362 14 DNA dna NN cord-010092-uftc8inx 2362 15 samples sample NNS cord-010092-uftc8inx 2362 16 from from IN cord-010092-uftc8inx 2362 17 patients patient NNS cord-010092-uftc8inx 2362 18 with with IN cord-010092-uftc8inx 2362 19 cancer cancer NN cord-010092-uftc8inx 2362 20 and and CC cord-010092-uftc8inx 2362 21 rare rare JJ cord-010092-uftc8inx 2362 22 disease disease NN cord-010092-uftc8inx 2362 23 . . . cord-010092-uftc8inx 2363 1 With with IN cord-010092-uftc8inx 2363 2 analysis analysis NN cord-010092-uftc8inx 2363 3 of of IN cord-010092-uftc8inx 2363 4 DNA DNA NNP cord-010092-uftc8inx 2363 5 by by IN cord-010092-uftc8inx 2363 6 WGS WGS NNP cord-010092-uftc8inx 2363 7 and and CC cord-010092-uftc8inx 2363 8 arrays array NNS cord-010092-uftc8inx 2363 9 becoming become VBG cord-010092-uftc8inx 2363 10 part part NN cord-010092-uftc8inx 2363 11 of of IN cord-010092-uftc8inx 2363 12 routine routine JJ cord-010092-uftc8inx 2363 13 clinical clinical JJ cord-010092-uftc8inx 2363 14 care care NN cord-010092-uftc8inx 2363 15 , , , cord-010092-uftc8inx 2363 16 blood blood NN cord-010092-uftc8inx 2363 17 services service NNS cord-010092-uftc8inx 2363 18 must must MD cord-010092-uftc8inx 2363 19 develop develop VB cord-010092-uftc8inx 2363 20 competencies competency NNS cord-010092-uftc8inx 2363 21 to to TO cord-010092-uftc8inx 2363 22 extract extract VB cord-010092-uftc8inx 2363 23 transfusion transfusion NN cord-010092-uftc8inx 2363 24 and and CC cord-010092-uftc8inx 2363 25 transplant transplant NN cord-010092-uftc8inx 2363 26 relevant relevant JJ cord-010092-uftc8inx 2363 27 information information NN cord-010092-uftc8inx 2363 28 from from IN cord-010092-uftc8inx 2363 29 clinical clinical JJ cord-010092-uftc8inx 2363 30 - - HYPH cord-010092-uftc8inx 2363 31 grade grade NN cord-010092-uftc8inx 2363 32 genotyping genotyping NN cord-010092-uftc8inx 2363 33 data datum NNS cord-010092-uftc8inx 2363 34 . . . cord-010092-uftc8inx 2364 1 Next next JJ cord-010092-uftc8inx 2364 2 - - HYPH cord-010092-uftc8inx 2364 3 generation generation NN cord-010092-uftc8inx 2364 4 sequencing sequencing NN cord-010092-uftc8inx 2364 5 ( ( -LRB- cord-010092-uftc8inx 2364 6 NGS NGS NNP cord-010092-uftc8inx 2364 7 ) ) -RRB- cord-010092-uftc8inx 2364 8 enables enable VBZ cord-010092-uftc8inx 2364 9 the the DT cord-010092-uftc8inx 2364 10 sequencing sequencing NN cord-010092-uftc8inx 2364 11 of of IN cord-010092-uftc8inx 2364 12 thousands thousand NNS cord-010092-uftc8inx 2364 13 of of IN cord-010092-uftc8inx 2364 14 genes gene NNS cord-010092-uftc8inx 2364 15 , , , cord-010092-uftc8inx 2364 16 the the DT cord-010092-uftc8inx 2364 17 exomes exome NNS cord-010092-uftc8inx 2364 18 , , , cord-010092-uftc8inx 2364 19 and and CC cord-010092-uftc8inx 2364 20 even even RB cord-010092-uftc8inx 2364 21 entire entire JJ cord-010092-uftc8inx 2364 22 genomes genome NNS cord-010092-uftc8inx 2364 23 by by IN cord-010092-uftc8inx 2364 24 single single JJ cord-010092-uftc8inx 2364 25 experiments experiment NNS cord-010092-uftc8inx 2364 26 at at IN cord-010092-uftc8inx 2364 27 a a DT cord-010092-uftc8inx 2364 28 reasonable reasonable JJ cord-010092-uftc8inx 2364 29 price price NN cord-010092-uftc8inx 2364 30 . . . cord-010092-uftc8inx 2365 1 There there EX cord-010092-uftc8inx 2365 2 have have VBP cord-010092-uftc8inx 2365 3 also also RB cord-010092-uftc8inx 2365 4 been be VBN cord-010092-uftc8inx 2365 5 advances advance NNS cord-010092-uftc8inx 2365 6 in in IN cord-010092-uftc8inx 2365 7 cytometry cytometry NN cord-010092-uftc8inx 2365 8 : : : cord-010092-uftc8inx 2366 1 Use use NN cord-010092-uftc8inx 2366 2 of of IN cord-010092-uftc8inx 2366 3 antibodies antibody NNS cord-010092-uftc8inx 2366 4 with with IN cord-010092-uftc8inx 2366 5 different different JJ cord-010092-uftc8inx 2366 6 fluorescence fluorescence NN cord-010092-uftc8inx 2366 7 tags tag NNS cord-010092-uftc8inx 2366 8 enables enable VBZ cord-010092-uftc8inx 2366 9 simultaneous simultaneous JJ cord-010092-uftc8inx 2366 10 monitoring monitoring NN cord-010092-uftc8inx 2366 11 of of IN cord-010092-uftc8inx 2366 12 the the DT cord-010092-uftc8inx 2366 13 expression expression NN cord-010092-uftc8inx 2366 14 of of IN cord-010092-uftc8inx 2366 15 dozens dozen NNS cord-010092-uftc8inx 2366 16 of of IN cord-010092-uftc8inx 2366 17 antigens antigen NNS cord-010092-uftc8inx 2366 18 . . . cord-010092-uftc8inx 2367 1 However however RB cord-010092-uftc8inx 2367 2 , , , cord-010092-uftc8inx 2367 3 immunological immunological JJ cord-010092-uftc8inx 2367 4 methods method NNS cord-010092-uftc8inx 2367 5 can can MD cord-010092-uftc8inx 2367 6 not not RB cord-010092-uftc8inx 2367 7 detect detect VB cord-010092-uftc8inx 2367 8 every every DT cord-010092-uftc8inx 2367 9 variant variant NN cord-010092-uftc8inx 2367 10 discovered discover VBN cord-010092-uftc8inx 2367 11 by by IN cord-010092-uftc8inx 2367 12 NGS NGS NNP cord-010092-uftc8inx 2367 13 . . . cord-010092-uftc8inx 2368 1 Genome genome NN cord-010092-uftc8inx 2368 2 sequencing sequencing NN cord-010092-uftc8inx 2368 3 reveals reveal VBZ cord-010092-uftc8inx 2368 4 not not RB cord-010092-uftc8inx 2368 5 only only RB cord-010092-uftc8inx 2368 6 the the DT cord-010092-uftc8inx 2368 7 exome exome NN cord-010092-uftc8inx 2368 8 but but CC cord-010092-uftc8inx 2368 9 also also RB cord-010092-uftc8inx 2368 10 the the DT cord-010092-uftc8inx 2368 11 regulatory regulatory JJ cord-010092-uftc8inx 2368 12 elements element NNS cord-010092-uftc8inx 2368 13 of of IN cord-010092-uftc8inx 2368 14 transcription transcription NN cord-010092-uftc8inx 2368 15 / / SYM cord-010092-uftc8inx 2368 16 translation translation NN cord-010092-uftc8inx 2368 17 , , , cord-010092-uftc8inx 2368 18 such such JJ cord-010092-uftc8inx 2368 19 as as IN cord-010092-uftc8inx 2368 20 promoters promoter NNS cord-010092-uftc8inx 2368 21 and and CC cord-010092-uftc8inx 2368 22 enhancers enhancer NNS cord-010092-uftc8inx 2368 23 . . . cord-010092-uftc8inx 2369 1 RNA RNA NNP cord-010092-uftc8inx 2369 2 sequencing sequencing NN cord-010092-uftc8inx 2369 3 determines determine VBZ cord-010092-uftc8inx 2369 4 which which WDT cord-010092-uftc8inx 2369 5 genes gene NNS cord-010092-uftc8inx 2369 6 and and CC cord-010092-uftc8inx 2369 7 spliced splice VBN cord-010092-uftc8inx 2369 8 transcripts transcript NNS cord-010092-uftc8inx 2369 9 are be VBP cord-010092-uftc8inx 2369 10 expressed express VBN cord-010092-uftc8inx 2369 11 . . . cord-010092-uftc8inx 2370 1 It -PRON- PRP cord-010092-uftc8inx 2370 2 is be VBZ cord-010092-uftc8inx 2370 3 amazing amazing JJ cord-010092-uftc8inx 2370 4 to to TO cord-010092-uftc8inx 2370 5 realize realize VB cord-010092-uftc8inx 2370 6 how how WRB cord-010092-uftc8inx 2370 7 much much JJ cord-010092-uftc8inx 2370 8 this this DT cord-010092-uftc8inx 2370 9 novel novel NN cord-010092-uftc8inx 2370 10 technology technology NN cord-010092-uftc8inx 2370 11 has have VBZ cord-010092-uftc8inx 2370 12 been be VBN cord-010092-uftc8inx 2370 13 contributing contribute VBG cord-010092-uftc8inx 2370 14 to to IN cord-010092-uftc8inx 2370 15 the the DT cord-010092-uftc8inx 2370 16 better well JJR cord-010092-uftc8inx 2370 17 understanding understanding NN cord-010092-uftc8inx 2370 18 of of IN cord-010092-uftc8inx 2370 19 various various JJ cord-010092-uftc8inx 2370 20 biological biological JJ cord-010092-uftc8inx 2370 21 phenomena phenomenon NNS cord-010092-uftc8inx 2370 22 . . . cord-010092-uftc8inx 2371 1 Since since IN cord-010092-uftc8inx 2371 2 the the DT cord-010092-uftc8inx 2371 3 initial initial JJ cord-010092-uftc8inx 2371 4 cloning cloning NN cord-010092-uftc8inx 2371 5 of of IN cord-010092-uftc8inx 2371 6 the the DT cord-010092-uftc8inx 2371 7 human human JJ cord-010092-uftc8inx 2371 8 blood blood NN cord-010092-uftc8inx 2371 9 group group NN cord-010092-uftc8inx 2371 10 A a DT cord-010092-uftc8inx 2371 11 transferase transferase NN cord-010092-uftc8inx 2371 12 cDNAs cdna VBZ cord-010092-uftc8inx 2371 13 in in IN cord-010092-uftc8inx 2371 14 the the DT cord-010092-uftc8inx 2371 15 early early JJ cord-010092-uftc8inx 2371 16 1990s 1990 NNS cord-010092-uftc8inx 2371 17 , , , cord-010092-uftc8inx 2371 18 we -PRON- PRP cord-010092-uftc8inx 2371 19 have have VBP cord-010092-uftc8inx 2371 20 been be VBN cord-010092-uftc8inx 2371 21 studying study VBG cord-010092-uftc8inx 2371 22 the the DT cord-010092-uftc8inx 2371 23 ABO ABO NNP cord-010092-uftc8inx 2371 24 genes gene NNS cord-010092-uftc8inx 2371 25 , , , cord-010092-uftc8inx 2371 26 A A NNP cord-010092-uftc8inx 2371 27 and and CC cord-010092-uftc8inx 2371 28 B B NNP cord-010092-uftc8inx 2371 29 glycosyltransferases glycosyltransferase NNS cord-010092-uftc8inx 2371 30 , , , cord-010092-uftc8inx 2371 31 and and CC cord-010092-uftc8inx 2371 32 A a NN cord-010092-uftc8inx 2371 33 and and CC cord-010092-uftc8inx 2371 34 B b NN cord-010092-uftc8inx 2371 35 oligosaccharide oligosaccharide NN cord-010092-uftc8inx 2371 36 antigens antigen NNS cord-010092-uftc8inx 2371 37 . . . cord-010092-uftc8inx 2372 1 Various various JJ cord-010092-uftc8inx 2372 2 scientific scientific JJ cord-010092-uftc8inx 2372 3 disciplines discipline NNS cord-010092-uftc8inx 2372 4 including include VBG cord-010092-uftc8inx 2372 5 genetics genetics NN cord-010092-uftc8inx 2372 6 , , , cord-010092-uftc8inx 2372 7 immunohematology immunohematology NN cord-010092-uftc8inx 2372 8 , , , cord-010092-uftc8inx 2372 9 biochemistry biochemistry NN cord-010092-uftc8inx 2372 10 , , , cord-010092-uftc8inx 2372 11 enzymology enzymology NN cord-010092-uftc8inx 2372 12 , , , cord-010092-uftc8inx 2372 13 and and CC cord-010092-uftc8inx 2372 14 glycobiology glycobiology NN cord-010092-uftc8inx 2372 15 have have VBP cord-010092-uftc8inx 2372 16 been be VBN cord-010092-uftc8inx 2372 17 applied apply VBN cord-010092-uftc8inx 2372 18 to to IN cord-010092-uftc8inx 2372 19 their -PRON- PRP$ cord-010092-uftc8inx 2372 20 study study NN cord-010092-uftc8inx 2372 21 . . . cord-010092-uftc8inx 2373 1 We -PRON- PRP cord-010092-uftc8inx 2373 2 have have VBP cord-010092-uftc8inx 2373 3 made make VBN cord-010092-uftc8inx 2373 4 several several JJ cord-010092-uftc8inx 2373 5 important important JJ cord-010092-uftc8inx 2373 6 scientific scientific JJ cord-010092-uftc8inx 2373 7 contributions contribution NNS cord-010092-uftc8inx 2373 8 . . . cord-010092-uftc8inx 2374 1 We -PRON- PRP cord-010092-uftc8inx 2374 2 demonstrated demonstrate VBD cord-010092-uftc8inx 2374 3 the the DT cord-010092-uftc8inx 2374 4 central central JJ cord-010092-uftc8inx 2374 5 dogma dogma NN cord-010092-uftc8inx 2374 6 of of IN cord-010092-uftc8inx 2374 7 ABO ABO NNP cord-010092-uftc8inx 2374 8 : : : cord-010092-uftc8inx 2375 1 the the DT cord-010092-uftc8inx 2375 2 A A NNP cord-010092-uftc8inx 2375 3 and and CC cord-010092-uftc8inx 2375 4 B b NN cord-010092-uftc8inx 2375 5 alleles allele NNS cord-010092-uftc8inx 2375 6 at at IN cord-010092-uftc8inx 2375 7 the the DT cord-010092-uftc8inx 2375 8 ABO ABO NNP cord-010092-uftc8inx 2375 9 genetic genetic JJ cord-010092-uftc8inx 2375 10 locus locus NN cord-010092-uftc8inx 2375 11 encode encode VBP cord-010092-uftc8inx 2375 12 A a NN cord-010092-uftc8inx 2375 13 and and CC cord-010092-uftc8inx 2375 14 B b NN cord-010092-uftc8inx 2375 15 transferases transferase NNS cord-010092-uftc8inx 2375 16 , , , cord-010092-uftc8inx 2375 17 which which WDT cord-010092-uftc8inx 2375 18 synthesize synthesize VBP cord-010092-uftc8inx 2375 19 A a NN cord-010092-uftc8inx 2375 20 and and CC cord-010092-uftc8inx 2375 21 B b NN cord-010092-uftc8inx 2375 22 antigens antigen NNS cord-010092-uftc8inx 2375 23 , , , cord-010092-uftc8inx 2375 24 respectively respectively RB cord-010092-uftc8inx 2375 25 . . . cord-010092-uftc8inx 2376 1 We -PRON- PRP cord-010092-uftc8inx 2376 2 elucidated elucidate VBD cord-010092-uftc8inx 2376 3 the the DT cord-010092-uftc8inx 2376 4 allelic allelic JJ cord-010092-uftc8inx 2376 5 basis basis NN cord-010092-uftc8inx 2376 6 of of IN cord-010092-uftc8inx 2376 7 the the DT cord-010092-uftc8inx 2376 8 ABO ABO NNP cord-010092-uftc8inx 2376 9 system system NN cord-010092-uftc8inx 2376 10 . . . cord-010092-uftc8inx 2377 1 We -PRON- PRP cord-010092-uftc8inx 2377 2 found find VBD cord-010092-uftc8inx 2377 3 4 4 CD cord-010092-uftc8inx 2377 4 amino amino NN cord-010092-uftc8inx 2377 5 acid acid NN cord-010092-uftc8inx 2377 6 substitutions substitution NNS cord-010092-uftc8inx 2377 7 between between IN cord-010092-uftc8inx 2377 8 A a NN cord-010092-uftc8inx 2377 9 and and CC cord-010092-uftc8inx 2377 10 B b NN cord-010092-uftc8inx 2377 11 transferases transferase NNS cord-010092-uftc8inx 2377 12 and and CC cord-010092-uftc8inx 2377 13 inactivating inactivate VBG cord-010092-uftc8inx 2377 14 mutations mutation NNS cord-010092-uftc8inx 2377 15 in in IN cord-010092-uftc8inx 2377 16 O o NN cord-010092-uftc8inx 2377 17 alleles allele NNS cord-010092-uftc8inx 2377 18 . . . cord-010092-uftc8inx 2378 1 We -PRON- PRP cord-010092-uftc8inx 2378 2 became become VBD cord-010092-uftc8inx 2378 3 the the DT cord-010092-uftc8inx 2378 4 first first JJ cord-010092-uftc8inx 2378 5 who who WP cord-010092-uftc8inx 2378 6 succeeded succeed VBD cord-010092-uftc8inx 2378 7 in in IN cord-010092-uftc8inx 2378 8 the the DT cord-010092-uftc8inx 2378 9 ABO ABO NNP cord-010092-uftc8inx 2378 10 genotyping genotyping NN cord-010092-uftc8inx 2378 11 , , , cord-010092-uftc8inx 2378 12 discriminating discriminate VBG cord-010092-uftc8inx 2378 13 the the DT cord-010092-uftc8inx 2378 14 AA AA NNP cord-010092-uftc8inx 2378 15 and and CC cord-010092-uftc8inx 2378 16 AO AO NNP cord-010092-uftc8inx 2378 17 genotypes genotype NNS cord-010092-uftc8inx 2378 18 , , , cord-010092-uftc8inx 2378 19 as as RB cord-010092-uftc8inx 2378 20 well well RB cord-010092-uftc8inx 2378 21 as as IN cord-010092-uftc8inx 2378 22 the the DT cord-010092-uftc8inx 2378 23 BB BB NNP cord-010092-uftc8inx 2378 24 and and CC cord-010092-uftc8inx 2378 25 BO BO NNP cord-010092-uftc8inx 2378 26 , , , cord-010092-uftc8inx 2378 27 which which WDT cord-010092-uftc8inx 2378 28 was be VBD cord-010092-uftc8inx 2378 29 impossible impossible JJ cord-010092-uftc8inx 2378 30 by by IN cord-010092-uftc8inx 2378 31 the the DT cord-010092-uftc8inx 2378 32 immunological immunological JJ cord-010092-uftc8inx 2378 33 approach approach NN cord-010092-uftc8inx 2378 34 . . . cord-010092-uftc8inx 2379 1 We -PRON- PRP cord-010092-uftc8inx 2379 2 have have VBP cord-010092-uftc8inx 2379 3 taken take VBN cord-010092-uftc8inx 2379 4 a a DT cord-010092-uftc8inx 2379 5 simple simple JJ cord-010092-uftc8inx 2379 6 experimental experimental JJ cord-010092-uftc8inx 2379 7 strategy strategy NN cord-010092-uftc8inx 2379 8 : : : cord-010092-uftc8inx 2379 9 preparation preparation NN cord-010092-uftc8inx 2379 10 of of IN cord-010092-uftc8inx 2379 11 eukaryotic eukaryotic JJ cord-010092-uftc8inx 2379 12 expression expression NN cord-010092-uftc8inx 2379 13 constructs construct NNS cord-010092-uftc8inx 2379 14 of of IN cord-010092-uftc8inx 2379 15 A a NN cord-010092-uftc8inx 2379 16 / / SYM cord-010092-uftc8inx 2379 17 B b NN cord-010092-uftc8inx 2379 18 transferases transferase NNS cord-010092-uftc8inx 2379 19 and and CC cord-010092-uftc8inx 2379 20 their -PRON- PRP$ cord-010092-uftc8inx 2379 21 derivatives derivative NNS cord-010092-uftc8inx 2379 22 , , , cord-010092-uftc8inx 2379 23 DNA dna NN cord-010092-uftc8inx 2379 24 transfection transfection NN cord-010092-uftc8inx 2379 25 to to IN cord-010092-uftc8inx 2379 26 human human JJ cord-010092-uftc8inx 2379 27 HeLa HeLa NNP cord-010092-uftc8inx 2379 28 cells cell NNS cord-010092-uftc8inx 2379 29 or or CC cord-010092-uftc8inx 2379 30 their -PRON- PRP$ cord-010092-uftc8inx 2379 31 sublines subline NNS cord-010092-uftc8inx 2379 32 , , , cord-010092-uftc8inx 2379 33 and and CC cord-010092-uftc8inx 2379 34 immunological immunological JJ cord-010092-uftc8inx 2379 35 detection detection NN cord-010092-uftc8inx 2379 36 of of IN cord-010092-uftc8inx 2379 37 the the DT cord-010092-uftc8inx 2379 38 A A NNP cord-010092-uftc8inx 2379 39 / / SYM cord-010092-uftc8inx 2379 40 B b NN cord-010092-uftc8inx 2379 41 antigen antigen NN cord-010092-uftc8inx 2379 42 and/or and/or CC cord-010092-uftc8inx 2379 43 biochemical biochemical JJ cord-010092-uftc8inx 2379 44 examination examination NN cord-010092-uftc8inx 2379 45 of of IN cord-010092-uftc8inx 2379 46 the the DT cord-010092-uftc8inx 2379 47 enzymatic enzymatic JJ cord-010092-uftc8inx 2379 48 activity activity NN cord-010092-uftc8inx 2379 49 . . . cord-010092-uftc8inx 2380 1 We -PRON- PRP cord-010092-uftc8inx 2380 2 used use VBD cord-010092-uftc8inx 2380 3 this this DT cord-010092-uftc8inx 2380 4 to to TO cord-010092-uftc8inx 2380 5 show show VB cord-010092-uftc8inx 2380 6 that that IN cord-010092-uftc8inx 2380 7 the the DT cord-010092-uftc8inx 2380 8 codons codon NNS cord-010092-uftc8inx 2380 9 266 266 CD cord-010092-uftc8inx 2380 10 and and CC cord-010092-uftc8inx 2380 11 268 268 CD cord-010092-uftc8inx 2380 12 are be VBP cord-010092-uftc8inx 2380 13 crucial crucial JJ cord-010092-uftc8inx 2380 14 in in IN cord-010092-uftc8inx 2380 15 determining determine VBG cord-010092-uftc8inx 2380 16 the the DT cord-010092-uftc8inx 2380 17 sugar sugar NN cord-010092-uftc8inx 2380 18 specificities specificity NNS cord-010092-uftc8inx 2380 19 of of IN cord-010092-uftc8inx 2380 20 GalNAc galnac NN cord-010092-uftc8inx 2380 21 / / SYM cord-010092-uftc8inx 2380 22 galactose galactose NN cord-010092-uftc8inx 2380 23 of of IN cord-010092-uftc8inx 2380 24 A a NN cord-010092-uftc8inx 2380 25 / / SYM cord-010092-uftc8inx 2380 26 B b NN cord-010092-uftc8inx 2380 27 transferases transferase NNS cord-010092-uftc8inx 2380 28 . . . cord-010092-uftc8inx 2381 1 We -PRON- PRP cord-010092-uftc8inx 2381 2 also also RB cord-010092-uftc8inx 2381 3 identified identify VBD cord-010092-uftc8inx 2381 4 mutations mutation NNS cord-010092-uftc8inx 2381 5 in in IN cord-010092-uftc8inx 2381 6 several several JJ cord-010092-uftc8inx 2381 7 subgroup subgroup NN cord-010092-uftc8inx 2381 8 alleles allele NNS cord-010092-uftc8inx 2381 9 causing cause VBG cord-010092-uftc8inx 2381 10 restricted restrict VBN cord-010092-uftc8inx 2381 11 substrate substrate NN cord-010092-uftc8inx 2381 12 use use NN cord-010092-uftc8inx 2381 13 and and CC cord-010092-uftc8inx 2381 14 diminished diminished JJ cord-010092-uftc8inx 2381 15 transferase transferase NN cord-010092-uftc8inx 2381 16 activity activity NN cord-010092-uftc8inx 2381 17 . . . cord-010092-uftc8inx 2382 1 We -PRON- PRP cord-010092-uftc8inx 2382 2 also also RB cord-010092-uftc8inx 2382 3 showed show VBD cord-010092-uftc8inx 2382 4 that that IN cord-010092-uftc8inx 2382 5 cis cis NNP cord-010092-uftc8inx 2382 6 - - HYPH cord-010092-uftc8inx 2382 7 AB AB NNP cord-010092-uftc8inx 2382 8 and and CC cord-010092-uftc8inx 2382 9 B(A B(A NNP cord-010092-uftc8inx 2382 10 ) ) -RRB- cord-010092-uftc8inx 2382 11 alleles allele NNS cord-010092-uftc8inx 2382 12 specifying specify VBG cord-010092-uftc8inx 2382 13 the the DT cord-010092-uftc8inx 2382 14 expression expression NN cord-010092-uftc8inx 2382 15 of of IN cord-010092-uftc8inx 2382 16 both both CC cord-010092-uftc8inx 2382 17 A A NNP cord-010092-uftc8inx 2382 18 and and CC cord-010092-uftc8inx 2382 19 B b NN cord-010092-uftc8inx 2382 20 antigens antigen NNS cord-010092-uftc8inx 2382 21 by by IN cord-010092-uftc8inx 2382 22 single single JJ cord-010092-uftc8inx 2382 23 alleles allele NNS cord-010092-uftc8inx 2382 24 encode encode VBP cord-010092-uftc8inx 2382 25 A a NN cord-010092-uftc8inx 2382 26 - - HYPH cord-010092-uftc8inx 2382 27 B b NN cord-010092-uftc8inx 2382 28 transferase transferase NN cord-010092-uftc8inx 2382 29 chimeras chimera NNS cord-010092-uftc8inx 2382 30 . . . cord-010092-uftc8inx 2383 1 Since since IN cord-010092-uftc8inx 2383 2 then then RB cord-010092-uftc8inx 2383 3 , , , cord-010092-uftc8inx 2383 4 other other JJ cord-010092-uftc8inx 2383 5 scientists scientist NNS cord-010092-uftc8inx 2383 6 have have VBP cord-010092-uftc8inx 2383 7 characterized characterize VBN cord-010092-uftc8inx 2383 8 more more JJR cord-010092-uftc8inx 2383 9 than than IN cord-010092-uftc8inx 2383 10 250 250 CD cord-010092-uftc8inx 2383 11 ABO ABO NNP cord-010092-uftc8inx 2383 12 alleles allele NNS cord-010092-uftc8inx 2383 13 . . . cord-010092-uftc8inx 2384 1 Recent recent JJ cord-010092-uftc8inx 2384 2 human human JJ cord-010092-uftc8inx 2384 3 genome genome NN cord-010092-uftc8inx 2384 4 sequencings sequencing NNS cord-010092-uftc8inx 2384 5 have have VBP cord-010092-uftc8inx 2384 6 identified identify VBN cord-010092-uftc8inx 2384 7 many many JJ cord-010092-uftc8inx 2384 8 more more JJR cord-010092-uftc8inx 2384 9 single single JJ cord-010092-uftc8inx 2384 10 nucleotide nucleotide JJ cord-010092-uftc8inx 2384 11 polymorphism polymorphism NN cord-010092-uftc8inx 2384 12 variations variation NNS cord-010092-uftc8inx 2384 13 . . . cord-010092-uftc8inx 2385 1 The the DT cord-010092-uftc8inx 2385 2 genome genome NN cord-010092-uftc8inx 2385 3 sequences sequence NNS cord-010092-uftc8inx 2385 4 of of IN cord-010092-uftc8inx 2385 5 many many JJ cord-010092-uftc8inx 2385 6 species specie NNS cord-010092-uftc8inx 2385 7 are be VBP cord-010092-uftc8inx 2385 8 also also RB cord-010092-uftc8inx 2385 9 available available JJ cord-010092-uftc8inx 2385 10 . . . cord-010092-uftc8inx 2386 1 Taking take VBG cord-010092-uftc8inx 2386 2 advantage advantage NN cord-010092-uftc8inx 2386 3 of of IN cord-010092-uftc8inx 2386 4 those those DT cord-010092-uftc8inx 2386 5 sequences sequence NNS cord-010092-uftc8inx 2386 6 and and CC cord-010092-uftc8inx 2386 7 associated associate VBD cord-010092-uftc8inx 2386 8 information information NN cord-010092-uftc8inx 2386 9 , , , cord-010092-uftc8inx 2386 10 we -PRON- PRP cord-010092-uftc8inx 2386 11 have have VBP cord-010092-uftc8inx 2386 12 expanded expand VBN cord-010092-uftc8inx 2386 13 our -PRON- PRP$ cord-010092-uftc8inx 2386 14 research research NN cord-010092-uftc8inx 2386 15 to to TO cord-010092-uftc8inx 2386 16 include include VB cord-010092-uftc8inx 2386 17 evolutionarily evolutionarily RB cord-010092-uftc8inx 2386 18 related relate VBN cord-010092-uftc8inx 2386 19 a1,3-Gal(NAc a1,3-gal(nac NN cord-010092-uftc8inx 2386 20 ) ) -RRB- cord-010092-uftc8inx 2386 21 transferases transferase NNS cord-010092-uftc8inx 2386 22 and and CC cord-010092-uftc8inx 2386 23 their -PRON- PRP$ cord-010092-uftc8inx 2386 24 genes gene NNS cord-010092-uftc8inx 2386 25 and and CC cord-010092-uftc8inx 2386 26 scaled scale VBD cord-010092-uftc8inx 2386 27 it -PRON- PRP cord-010092-uftc8inx 2386 28 up up RP cord-010092-uftc8inx 2386 29 from from IN cord-010092-uftc8inx 2386 30 the the DT cord-010092-uftc8inx 2386 31 genetic genetic JJ cord-010092-uftc8inx 2386 32 to to TO cord-010092-uftc8inx 2386 33 genomic genomic JJ cord-010092-uftc8inx 2386 34 level level NN cord-010092-uftc8inx 2386 35 . . . cord-010092-uftc8inx 2387 1 In in IN cord-010092-uftc8inx 2387 2 this this DT cord-010092-uftc8inx 2387 3 talk talk NN cord-010092-uftc8inx 2387 4 , , , cord-010092-uftc8inx 2387 5 I -PRON- PRP cord-010092-uftc8inx 2387 6 would would MD cord-010092-uftc8inx 2387 7 like like VB cord-010092-uftc8inx 2387 8 to to TO cord-010092-uftc8inx 2387 9 present present VB cord-010092-uftc8inx 2387 10 the the DT cord-010092-uftc8inx 2387 11 followings following NNS cord-010092-uftc8inx 2387 12 . . . cord-010092-uftc8inx 2388 1 1 1 LS cord-010092-uftc8inx 2388 2 : : : cord-010092-uftc8inx 2389 1 Our -PRON- PRP$ cord-010092-uftc8inx 2389 2 elucidation elucidation NN cord-010092-uftc8inx 2389 3 of of IN cord-010092-uftc8inx 2389 4 the the DT cord-010092-uftc8inx 2389 5 molecular molecular JJ cord-010092-uftc8inx 2389 6 genetic genetic JJ cord-010092-uftc8inx 2389 7 basis basis NN cord-010092-uftc8inx 2389 8 of of IN cord-010092-uftc8inx 2389 9 the the DT cord-010092-uftc8inx 2389 10 ABO ABO NNP cord-010092-uftc8inx 2389 11 blood blood NN cord-010092-uftc8inx 2389 12 group group NN cord-010092-uftc8inx 2389 13 system system NN cord-010092-uftc8inx 2389 14 ( ( -LRB- cord-010092-uftc8inx 2389 15 as as IN cord-010092-uftc8inx 2389 16 requested request VBN cord-010092-uftc8inx 2389 17 by by IN cord-010092-uftc8inx 2389 18 the the DT cord-010092-uftc8inx 2389 19 organizer organizer NN cord-010092-uftc8inx 2389 20 ) ) -RRB- cord-010092-uftc8inx 2389 21 ; ; : cord-010092-uftc8inx 2389 22 2 2 LS cord-010092-uftc8inx 2389 23 : : : cord-010092-uftc8inx 2389 24 Identification identification NN cord-010092-uftc8inx 2389 25 of of IN cord-010092-uftc8inx 2389 26 novel novel NN cord-010092-uftc8inx 2389 27 ABO ABO NNP cord-010092-uftc8inx 2389 28 alleles allele NNS cord-010092-uftc8inx 2389 29 by by IN cord-010092-uftc8inx 2389 30 others other NNS cord-010092-uftc8inx 2389 31 ; ; : cord-010092-uftc8inx 2389 32 3 3 LS cord-010092-uftc8inx 2389 33 : : : cord-010092-uftc8inx 2389 34 More More JJR cord-010092-uftc8inx 2389 35 SNP SNP NNP cord-010092-uftc8inx 2389 36 data datum NNS cord-010092-uftc8inx 2389 37 from from IN cord-010092-uftc8inx 2389 38 genome genome NN cord-010092-uftc8inx 2389 39 sequences sequence NNS cord-010092-uftc8inx 2389 40 and and CC cord-010092-uftc8inx 2389 41 potential potential JJ cord-010092-uftc8inx 2389 42 problems problem NNS cord-010092-uftc8inx 2389 43 for for IN cord-010092-uftc8inx 2389 44 ABO ABO NNP cord-010092-uftc8inx 2389 45 genotyping genotyping NN cord-010092-uftc8inx 2389 46 ; ; : cord-010092-uftc8inx 2389 47 4 4 CD cord-010092-uftc8inx 2389 48 : : : cord-010092-uftc8inx 2389 49 Findings finding NNS cord-010092-uftc8inx 2389 50 obtained obtain VBN cord-010092-uftc8inx 2389 51 from from IN cord-010092-uftc8inx 2389 52 analysis analysis NN cord-010092-uftc8inx 2389 53 of of IN cord-010092-uftc8inx 2389 54 ABO ABO NNP cord-010092-uftc8inx 2389 55 genes gene NNS cord-010092-uftc8inx 2389 56 from from IN cord-010092-uftc8inx 2389 57 other other JJ cord-010092-uftc8inx 2389 58 species specie NNS cord-010092-uftc8inx 2389 59 ; ; : cord-010092-uftc8inx 2389 60 bacteria bacteria NNS cord-010092-uftc8inx 2389 61 , , , cord-010092-uftc8inx 2389 62 vertebrates vertebrate NNS cord-010092-uftc8inx 2389 63 , , , cord-010092-uftc8inx 2389 64 to to IN cord-010092-uftc8inx 2389 65 primates primate NNS cord-010092-uftc8inx 2389 66 ; ; : cord-010092-uftc8inx 2389 67 5 5 CD cord-010092-uftc8inx 2389 68 : : : cord-010092-uftc8inx 2389 69 a1,3-Gal(NAc a1,3-Gal(NAc NNP cord-010092-uftc8inx 2389 70 ) ) -RRB- cord-010092-uftc8inx 2389 71 transferases transferase NNS cord-010092-uftc8inx 2389 72 and and CC cord-010092-uftc8inx 2389 73 their -PRON- PRP$ cord-010092-uftc8inx 2389 74 genes gene NNS cord-010092-uftc8inx 2389 75 and and CC cord-010092-uftc8inx 2389 76 the the DT cord-010092-uftc8inx 2389 77 crosstalk crosstalk NN cord-010092-uftc8inx 2389 78 between between IN cord-010092-uftc8inx 2389 79 A a DT cord-010092-uftc8inx 2389 80 transferase transferase NN cord-010092-uftc8inx 2389 81 and and CC cord-010092-uftc8inx 2389 82 Forssman Forssman NNP cord-010092-uftc8inx 2389 83 glycolipid glycolipid NN cord-010092-uftc8inx 2389 84 synthase synthase NN cord-010092-uftc8inx 2389 85 ( ( -LRB- cord-010092-uftc8inx 2389 86 FS FS NNP cord-010092-uftc8inx 2389 87 ) ) -RRB- cord-010092-uftc8inx 2389 88 ; ; : cord-010092-uftc8inx 2389 89 and and CC cord-010092-uftc8inx 2389 90 6 6 CD cord-010092-uftc8inx 2389 91 : : : cord-010092-uftc8inx 2389 92 the the DT cord-010092-uftc8inx 2389 93 potential potential JJ cord-010092-uftc8inx 2389 94 causes cause NNS cord-010092-uftc8inx 2389 95 of of IN cord-010092-uftc8inx 2389 96 generation generation NN cord-010092-uftc8inx 2389 97 of of IN cord-010092-uftc8inx 2389 98 ABO ABO NNP cord-010092-uftc8inx 2389 99 polymorphism polymorphism NN cord-010092-uftc8inx 2389 100 and and CC cord-010092-uftc8inx 2389 101 of of IN cord-010092-uftc8inx 2389 102 species species NN cord-010092-uftc8inx 2389 103 variations variation NNS cord-010092-uftc8inx 2389 104 of of IN cord-010092-uftc8inx 2389 105 the the DT cord-010092-uftc8inx 2389 106 GBGT1 GBGT1 NNP cord-010092-uftc8inx 2389 107 gene gene NN cord-010092-uftc8inx 2389 108 specifying specify VBG cord-010092-uftc8inx 2389 109 the the DT cord-010092-uftc8inx 2389 110 FORS FORS NNP cord-010092-uftc8inx 2389 111 polymorphism polymorphism NN cord-010092-uftc8inx 2389 112 . . . cord-010092-uftc8inx 2390 1 In in IN cord-010092-uftc8inx 2390 2 recent recent JJ cord-010092-uftc8inx 2390 3 years year NNS cord-010092-uftc8inx 2390 4 , , , cord-010092-uftc8inx 2390 5 there there EX cord-010092-uftc8inx 2390 6 has have VBZ cord-010092-uftc8inx 2390 7 been be VBN cord-010092-uftc8inx 2390 8 a a DT cord-010092-uftc8inx 2390 9 concerted concerted JJ cord-010092-uftc8inx 2390 10 effort effort NN cord-010092-uftc8inx 2390 11 to to TO cord-010092-uftc8inx 2390 12 improve improve VB cord-010092-uftc8inx 2390 13 our -PRON- PRP$ cord-010092-uftc8inx 2390 14 understanding understanding NN cord-010092-uftc8inx 2390 15 of of IN cord-010092-uftc8inx 2390 16 the the DT cord-010092-uftc8inx 2390 17 quality quality NN cord-010092-uftc8inx 2390 18 and and CC cord-010092-uftc8inx 2390 19 effectiveness effectiveness NN cord-010092-uftc8inx 2390 20 of of IN cord-010092-uftc8inx 2390 21 transfused transfuse VBN cord-010092-uftc8inx 2390 22 blood blood NN cord-010092-uftc8inx 2390 23 components component NNS cord-010092-uftc8inx 2390 24 . . . cord-010092-uftc8inx 2391 1 The the DT cord-010092-uftc8inx 2391 2 expanding expand VBG cord-010092-uftc8inx 2391 3 use use NN cord-010092-uftc8inx 2391 4 of of IN cord-010092-uftc8inx 2391 5 large large JJ cord-010092-uftc8inx 2391 6 datasets dataset NNS cord-010092-uftc8inx 2391 7 built build VBN cord-010092-uftc8inx 2391 8 from from IN cord-010092-uftc8inx 2391 9 electronic electronic JJ cord-010092-uftc8inx 2391 10 health health NN cord-010092-uftc8inx 2391 11 records record NNS cord-010092-uftc8inx 2391 12 allows allow VBZ cord-010092-uftc8inx 2391 13 the the DT cord-010092-uftc8inx 2391 14 investigation investigation NN cord-010092-uftc8inx 2391 15 of of IN cord-010092-uftc8inx 2391 16 potential potential JJ cord-010092-uftc8inx 2391 17 benefits benefit NNS cord-010092-uftc8inx 2391 18 or or CC cord-010092-uftc8inx 2391 19 adverse adverse JJ cord-010092-uftc8inx 2391 20 outcomes outcome NNS cord-010092-uftc8inx 2391 21 associated associate VBN cord-010092-uftc8inx 2391 22 with with IN cord-010092-uftc8inx 2391 23 transfusion transfusion NN cord-010092-uftc8inx 2391 24 therapy therapy NN cord-010092-uftc8inx 2391 25 . . . cord-010092-uftc8inx 2392 1 Together together RB cord-010092-uftc8inx 2392 2 with with IN cord-010092-uftc8inx 2392 3 data datum NNS cord-010092-uftc8inx 2392 4 collected collect VBN cord-010092-uftc8inx 2392 5 on on IN cord-010092-uftc8inx 2392 6 blood blood NN cord-010092-uftc8inx 2392 7 donors donor NNS cord-010092-uftc8inx 2392 8 and and CC cord-010092-uftc8inx 2392 9 components component NNS cord-010092-uftc8inx 2392 10 , , , cord-010092-uftc8inx 2392 11 these these DT cord-010092-uftc8inx 2392 12 datasets dataset NNS cord-010092-uftc8inx 2392 13 permit permit VBP cord-010092-uftc8inx 2392 14 an an DT cord-010092-uftc8inx 2392 15 evaluation evaluation NN cord-010092-uftc8inx 2392 16 of of IN cord-010092-uftc8inx 2392 17 the the DT cord-010092-uftc8inx 2392 18 effect effect NN cord-010092-uftc8inx 2392 19 of of IN cord-010092-uftc8inx 2392 20 donor donor NN cord-010092-uftc8inx 2392 21 and and CC cord-010092-uftc8inx 2392 22 blood blood NN cord-010092-uftc8inx 2392 23 component component NN cord-010092-uftc8inx 2392 24 factors factor NNS cord-010092-uftc8inx 2392 25 on on IN cord-010092-uftc8inx 2392 26 transfusion transfusion NN cord-010092-uftc8inx 2392 27 recipient recipient NN cord-010092-uftc8inx 2392 28 outcomes outcome NNS cord-010092-uftc8inx 2392 29 . . . cord-010092-uftc8inx 2393 1 Large large JJ cord-010092-uftc8inx 2393 2 linked link VBN cord-010092-uftc8inx 2393 3 donor donor NN cord-010092-uftc8inx 2393 4 - - HYPH cord-010092-uftc8inx 2393 5 component component NN cord-010092-uftc8inx 2393 6 recipient recipient NN cord-010092-uftc8inx 2393 7 datasets dataset NNS cord-010092-uftc8inx 2393 8 provide provide VBP cord-010092-uftc8inx 2393 9 the the DT cord-010092-uftc8inx 2393 10 power power NN cord-010092-uftc8inx 2393 11 to to TO cord-010092-uftc8inx 2393 12 study study VB cord-010092-uftc8inx 2393 13 exposures exposure NNS cord-010092-uftc8inx 2393 14 relevant relevant JJ cord-010092-uftc8inx 2393 15 to to IN cord-010092-uftc8inx 2393 16 transfusion transfusion NN cord-010092-uftc8inx 2393 17 efficacy efficacy NN cord-010092-uftc8inx 2393 18 and and CC cord-010092-uftc8inx 2393 19 safety safety NN cord-010092-uftc8inx 2393 20 , , , cord-010092-uftc8inx 2393 21 many many JJ cord-010092-uftc8inx 2393 22 of of IN cord-010092-uftc8inx 2393 23 which which WDT cord-010092-uftc8inx 2393 24 may may MD cord-010092-uftc8inx 2393 25 not not RB cord-010092-uftc8inx 2393 26 otherwise otherwise RB cord-010092-uftc8inx 2393 27 be be VB cord-010092-uftc8inx 2393 28 amenable amenable JJ cord-010092-uftc8inx 2393 29 to to TO cord-010092-uftc8inx 2393 30 study study VB cord-010092-uftc8inx 2393 31 for for IN cord-010092-uftc8inx 2393 32 practicality practicality NN cord-010092-uftc8inx 2393 33 or or CC cord-010092-uftc8inx 2393 34 sample sample NN cord-010092-uftc8inx 2393 35 size size NN cord-010092-uftc8inx 2393 36 reasons reason NNS cord-010092-uftc8inx 2393 37 . . . cord-010092-uftc8inx 2394 1 Analysis analysis NN cord-010092-uftc8inx 2394 2 of of IN cord-010092-uftc8inx 2394 3 these these DT cord-010092-uftc8inx 2394 4 large large JJ cord-010092-uftc8inx 2394 5 blood blood NN cord-010092-uftc8inx 2394 6 banking banking NN cord-010092-uftc8inx 2394 7 - - HYPH cord-010092-uftc8inx 2394 8 transfusion transfusion NN cord-010092-uftc8inx 2394 9 medicine medicine NN cord-010092-uftc8inx 2394 10 datasets dataset NNS cord-010092-uftc8inx 2394 11 allow allow VBP cord-010092-uftc8inx 2394 12 for for IN cord-010092-uftc8inx 2394 13 characterization characterization NN cord-010092-uftc8inx 2394 14 of of IN cord-010092-uftc8inx 2394 15 the the DT cord-010092-uftc8inx 2394 16 populations population NNS cord-010092-uftc8inx 2394 17 under under IN cord-010092-uftc8inx 2394 18 study study NN cord-010092-uftc8inx 2394 19 and and CC cord-010092-uftc8inx 2394 20 provide provide VB cord-010092-uftc8inx 2394 21 an an DT cord-010092-uftc8inx 2394 22 evidence evidence NN cord-010092-uftc8inx 2394 23 base base NN cord-010092-uftc8inx 2394 24 for for IN cord-010092-uftc8inx 2394 25 future future JJ cord-010092-uftc8inx 2394 26 clinical clinical JJ cord-010092-uftc8inx 2394 27 studies study NNS cord-010092-uftc8inx 2394 28 . . . cord-010092-uftc8inx 2395 1 Knowledge knowledge NN cord-010092-uftc8inx 2395 2 generated generate VBN cord-010092-uftc8inx 2395 3 from from IN cord-010092-uftc8inx 2395 4 linked link VBN cord-010092-uftc8inx 2395 5 analyses analysis NNS cord-010092-uftc8inx 2395 6 has have VBZ cord-010092-uftc8inx 2395 7 the the DT cord-010092-uftc8inx 2395 8 potential potential NN cord-010092-uftc8inx 2395 9 to to TO cord-010092-uftc8inx 2395 10 change change VB cord-010092-uftc8inx 2395 11 the the DT cord-010092-uftc8inx 2395 12 way way NN cord-010092-uftc8inx 2395 13 donors donor NNS cord-010092-uftc8inx 2395 14 are be VBP cord-010092-uftc8inx 2395 15 selected select VBN cord-010092-uftc8inx 2395 16 and and CC cord-010092-uftc8inx 2395 17 how how WRB cord-010092-uftc8inx 2395 18 components component NNS cord-010092-uftc8inx 2395 19 are be VBP cord-010092-uftc8inx 2395 20 processed process VBN cord-010092-uftc8inx 2395 21 , , , cord-010092-uftc8inx 2395 22 stored store VBN cord-010092-uftc8inx 2395 23 and and CC cord-010092-uftc8inx 2395 24 allocated allocate VBN cord-010092-uftc8inx 2395 25 . . . cord-010092-uftc8inx 2396 1 However however RB cord-010092-uftc8inx 2396 2 , , , cord-010092-uftc8inx 2396 3 unrecognized unrecognized JJ cord-010092-uftc8inx 2396 4 confounding confound VBG cord-010092-uftc8inx 2396 5 and and CC cord-010092-uftc8inx 2396 6 biased biased JJ cord-010092-uftc8inx 2396 7 statistical statistical JJ cord-010092-uftc8inx 2396 8 methods method NNS cord-010092-uftc8inx 2396 9 continue continue VBP cord-010092-uftc8inx 2396 10 to to TO cord-010092-uftc8inx 2396 11 be be VB cord-010092-uftc8inx 2396 12 limitations limitation NNS cord-010092-uftc8inx 2396 13 in in IN cord-010092-uftc8inx 2396 14 the the DT cord-010092-uftc8inx 2396 15 study study NN cord-010092-uftc8inx 2396 16 of of IN cord-010092-uftc8inx 2396 17 transfusion transfusion NN cord-010092-uftc8inx 2396 18 exposures exposure NNS cord-010092-uftc8inx 2396 19 and and CC cord-010092-uftc8inx 2396 20 patient patient JJ cord-010092-uftc8inx 2396 21 outcomes outcome NNS cord-010092-uftc8inx 2396 22 . . . cord-010092-uftc8inx 2397 1 Results result NNS cord-010092-uftc8inx 2397 2 of of IN cord-010092-uftc8inx 2397 3 observational observational JJ cord-010092-uftc8inx 2397 4 studies study NNS cord-010092-uftc8inx 2397 5 of of IN cord-010092-uftc8inx 2397 6 blood blood NN cord-010092-uftc8inx 2397 7 donor donor NN cord-010092-uftc8inx 2397 8 demographics demographic NNS cord-010092-uftc8inx 2397 9 , , , cord-010092-uftc8inx 2397 10 storage storage NN cord-010092-uftc8inx 2397 11 age age NN cord-010092-uftc8inx 2397 12 , , , cord-010092-uftc8inx 2397 13 and and CC cord-010092-uftc8inx 2397 14 transfusion transfusion NN cord-010092-uftc8inx 2397 15 practice practice NN cord-010092-uftc8inx 2397 16 have have VBP cord-010092-uftc8inx 2397 17 been be VBN cord-010092-uftc8inx 2397 18 conflicting conflict VBG cord-010092-uftc8inx 2397 19 . . . cord-010092-uftc8inx 2398 1 This this DT cord-010092-uftc8inx 2398 2 review review NN cord-010092-uftc8inx 2398 3 will will MD cord-010092-uftc8inx 2398 4 summarize summarize VB cord-010092-uftc8inx 2398 5 statistical statistical JJ cord-010092-uftc8inx 2398 6 and and CC cord-010092-uftc8inx 2398 7 methodological methodological JJ cord-010092-uftc8inx 2398 8 challenges challenge NNS cord-010092-uftc8inx 2398 9 in in IN cord-010092-uftc8inx 2398 10 the the DT cord-010092-uftc8inx 2398 11 analysis analysis NN cord-010092-uftc8inx 2398 12 of of IN cord-010092-uftc8inx 2398 13 linked link VBN cord-010092-uftc8inx 2398 14 blood blood NN cord-010092-uftc8inx 2398 15 donor donor NN cord-010092-uftc8inx 2398 16 , , , cord-010092-uftc8inx 2398 17 component component NN cord-010092-uftc8inx 2398 18 , , , cord-010092-uftc8inx 2398 19 and and CC cord-010092-uftc8inx 2398 20 transfusion transfusion NN cord-010092-uftc8inx 2398 21 recipient recipient NN cord-010092-uftc8inx 2398 22 outcomes outcome NNS cord-010092-uftc8inx 2398 23 . . . cord-010092-uftc8inx 2399 1 4C 4c LS cord-010092-uftc8inx 2399 2 - - : cord-010092-uftc8inx 2399 3 S20 S20 NNP cord-010092-uftc8inx 2399 4 - - HYPH cord-010092-uftc8inx 2399 5 01 01 CD cord-010092-uftc8inx 2400 1 A a DT cord-010092-uftc8inx 2400 2 LARGE large JJ cord-010092-uftc8inx 2400 3 DELETION deletion NN cord-010092-uftc8inx 2400 4 SPANNING spanning NN cord-010092-uftc8inx 2400 5 XG XG NNP cord-010092-uftc8inx 2400 6 XG XG NNP cord-010092-uftc8inx 2400 7 AND and CC cord-010092-uftc8inx 2400 8 GYG2 GYG2 NNP cord-010092-uftc8inx 2400 9 GYG2 GYG2 NNP cord-010092-uftc8inx 2400 10 CONSTITUTES constitute VBZ cord-010092-uftc8inx 2400 11 A a DT cord-010092-uftc8inx 2400 12 GENETIC genetic JJ cord-010092-uftc8inx 2400 13 BASIS basis NN cord-010092-uftc8inx 2400 14 OF of IN cord-010092-uftc8inx 2400 15 THE the DT cord-010092-uftc8inx 2400 16 XG XG NNP cord-010092-uftc8inx 2401 1 NULL NULL NNP cord-010092-uftc8inx 2401 2 PHENOTYPE PHENOTYPE NNP cord-010092-uftc8inx 2401 3 , , , cord-010092-uftc8inx 2401 4 UNDERLYING underlying JJ cord-010092-uftc8inx 2401 5 ANTI ANTI NNP cord-010092-uftc8inx 2401 6 - - HYPH cord-010092-uftc8inx 2401 7 Xg Xg NNP cord-010092-uftc8inx 2402 1 a a DT cord-010092-uftc8inx 2402 2 PRODUCTION production NN cord-010092-uftc8inx 2402 3 Background background NN cord-010092-uftc8inx 2402 4 : : : cord-010092-uftc8inx 2403 1 The the DT cord-010092-uftc8inx 2403 2 XG XG NNP cord-010092-uftc8inx 2403 3 blood blood NN cord-010092-uftc8inx 2403 4 group group NN cord-010092-uftc8inx 2403 5 system system NN cord-010092-uftc8inx 2403 6 comprises comprise VBZ cord-010092-uftc8inx 2403 7 the the DT cord-010092-uftc8inx 2403 8 homologous homologous JJ cord-010092-uftc8inx 2403 9 antigens antigen NNS cord-010092-uftc8inx 2403 10 Xg Xg NNP cord-010092-uftc8inx 2403 11 a a DT cord-010092-uftc8inx 2403 12 and and CC cord-010092-uftc8inx 2403 13 CD99 CD99 NNP cord-010092-uftc8inx 2403 14 . . . cord-010092-uftc8inx 2404 1 The the DT cord-010092-uftc8inx 2404 2 CD99 CD99 NNP cord-010092-uftc8inx 2404 3 gene gene NN cord-010092-uftc8inx 2404 4 resides reside VBZ cord-010092-uftc8inx 2404 5 within within IN cord-010092-uftc8inx 2404 6 pseudoautosomal pseudoautosomal NNP cord-010092-uftc8inx 2404 7 region region NN cord-010092-uftc8inx 2404 8 1 1 CD cord-010092-uftc8inx 2404 9 on on IN cord-010092-uftc8inx 2404 10 the the DT cord-010092-uftc8inx 2404 11 short short JJ cord-010092-uftc8inx 2404 12 arms arm NNS cord-010092-uftc8inx 2404 13 of of IN cord-010092-uftc8inx 2404 14 the the DT cord-010092-uftc8inx 2404 15 sex sex NN cord-010092-uftc8inx 2404 16 chromosomes chromosome NNS cord-010092-uftc8inx 2404 17 and and CC cord-010092-uftc8inx 2404 18 thus thus RB cord-010092-uftc8inx 2404 19 mimics mimic VBZ cord-010092-uftc8inx 2404 20 autosomal autosomal JJ cord-010092-uftc8inx 2404 21 inheritance inheritance NN cord-010092-uftc8inx 2404 22 . . . cord-010092-uftc8inx 2405 1 XG XG NNP cord-010092-uftc8inx 2405 2 , , , cord-010092-uftc8inx 2405 3 on on IN cord-010092-uftc8inx 2405 4 the the DT cord-010092-uftc8inx 2405 5 other other JJ cord-010092-uftc8inx 2405 6 hand hand NN cord-010092-uftc8inx 2405 7 , , , cord-010092-uftc8inx 2405 8 is be VBZ cord-010092-uftc8inx 2405 9 X x NN cord-010092-uftc8inx 2405 10 - - VBN cord-010092-uftc8inx 2405 11 linked link VBN cord-010092-uftc8inx 2405 12 and and CC cord-010092-uftc8inx 2405 13 straddles straddle VBZ cord-010092-uftc8inx 2405 14 the the DT cord-010092-uftc8inx 2405 15 pseudoautosomal pseudoautosomal NN cord-010092-uftc8inx 2405 16 boundary boundary NN cord-010092-uftc8inx 2405 17 ; ; : cord-010092-uftc8inx 2405 18 a a DT cord-010092-uftc8inx 2405 19 truncated truncated JJ cord-010092-uftc8inx 2405 20 pseudogene pseudogene NN cord-010092-uftc8inx 2405 21 composed compose VBN cord-010092-uftc8inx 2405 22 of of IN cord-010092-uftc8inx 2405 23 only only RB cord-010092-uftc8inx 2405 24 the the DT cord-010092-uftc8inx 2405 25 first first JJ cord-010092-uftc8inx 2405 26 3 3 CD cord-010092-uftc8inx 2405 27 exons exon NNS cord-010092-uftc8inx 2405 28 remains remain VBZ cord-010092-uftc8inx 2405 29 on on IN cord-010092-uftc8inx 2405 30 the the DT cord-010092-uftc8inx 2405 31 Y Y NNP cord-010092-uftc8inx 2405 32 chromosome chromosome NN cord-010092-uftc8inx 2405 33 and and CC cord-010092-uftc8inx 2405 34 therefore therefore RB cord-010092-uftc8inx 2405 35 males male NNS cord-010092-uftc8inx 2405 36 carry carry VBP cord-010092-uftc8inx 2405 37 a a DT cord-010092-uftc8inx 2405 38 sole sole JJ cord-010092-uftc8inx 2405 39 full full JJ cord-010092-uftc8inx 2405 40 - - HYPH cord-010092-uftc8inx 2405 41 length length NN cord-010092-uftc8inx 2405 42 copy copy NN cord-010092-uftc8inx 2405 43 of of IN cord-010092-uftc8inx 2405 44 XG XG NNP cord-010092-uftc8inx 2405 45 . . . cord-010092-uftc8inx 2406 1 This this DT cord-010092-uftc8inx 2406 2 phenomenon phenomenon NN cord-010092-uftc8inx 2406 3 manifests manifest VBZ cord-010092-uftc8inx 2406 4 as as IN cord-010092-uftc8inx 2406 5 asymmetric asymmetric JJ cord-010092-uftc8inx 2406 6 frequencies frequency NNS cord-010092-uftc8inx 2406 7 of of IN cord-010092-uftc8inx 2406 8 the the DT cord-010092-uftc8inx 2406 9 Xg(a+ Xg(a+ NNP cord-010092-uftc8inx 2406 10 ) ) -RRB- cord-010092-uftc8inx 2406 11 phenotype phenotype NN cord-010092-uftc8inx 2406 12 between between IN cord-010092-uftc8inx 2406 13 the the DT cord-010092-uftc8inx 2406 14 sexes sex NNS cord-010092-uftc8inx 2406 15 : : : cord-010092-uftc8inx 2406 16 roughly roughly RB cord-010092-uftc8inx 2406 17 11 11 CD cord-010092-uftc8inx 2406 18 % % NN cord-010092-uftc8inx 2406 19 of of IN cord-010092-uftc8inx 2406 20 women woman NNS cord-010092-uftc8inx 2406 21 and and CC cord-010092-uftc8inx 2406 22 34 34 CD cord-010092-uftc8inx 2406 23 % % NN cord-010092-uftc8inx 2406 24 of of IN cord-010092-uftc8inx 2406 25 men man NNS cord-010092-uftc8inx 2406 26 are be VBP cord-010092-uftc8inx 2406 27 Xg(aÀ xg(aà CD cord-010092-uftc8inx 2406 28 ) ) -RRB- cord-010092-uftc8inx 2406 29 . . . cord-010092-uftc8inx 2407 1 Also also RB cord-010092-uftc8inx 2407 2 , , , cord-010092-uftc8inx 2407 3 whilst whilst IN cord-010092-uftc8inx 2407 4 Xg Xg NNP cord-010092-uftc8inx 2407 5 a a DT cord-010092-uftc8inx 2407 6 immunization immunization NN cord-010092-uftc8inx 2407 7 is be VBZ cord-010092-uftc8inx 2407 8 rare rare JJ cord-010092-uftc8inx 2407 9 , , , cord-010092-uftc8inx 2407 10 the the DT cord-010092-uftc8inx 2407 11 vast vast JJ cord-010092-uftc8inx 2407 12 majority majority NN cord-010092-uftc8inx 2407 13 of of IN cord-010092-uftc8inx 2407 14 all all DT cord-010092-uftc8inx 2407 15 anti anti NNP cord-010092-uftc8inx 2407 16 - - JJ cord-010092-uftc8inx 2407 17 Xg Xg NNP cord-010092-uftc8inx 2407 18 a a DT cord-010092-uftc8inx 2407 19 makers maker NNS cord-010092-uftc8inx 2407 20 reported report VBN cord-010092-uftc8inx 2407 21 are be VBP cord-010092-uftc8inx 2407 22 men man NNS cord-010092-uftc8inx 2407 23 . . . cord-010092-uftc8inx 2408 1 Recently recently RB cord-010092-uftc8inx 2408 2 , , , cord-010092-uftc8inx 2408 3 we -PRON- PRP cord-010092-uftc8inx 2408 4 reported report VBD cord-010092-uftc8inx 2408 5 that that IN cord-010092-uftc8inx 2408 6 the the DT cord-010092-uftc8inx 2408 7 rs311103C rs311103C NNP cord-010092-uftc8inx 2408 8 variant variant NN cord-010092-uftc8inx 2408 9 disrupts disrupt VBZ cord-010092-uftc8inx 2408 10 a a DT cord-010092-uftc8inx 2408 11 GATA GATA NNP cord-010092-uftc8inx 2408 12 motif motif NN cord-010092-uftc8inx 2408 13 between between IN cord-010092-uftc8inx 2408 14 XG XG NNP cord-010092-uftc8inx 2408 15 and and CC cord-010092-uftc8inx 2408 16 CD99 CD99 NNP cord-010092-uftc8inx 2408 17 . . . cord-010092-uftc8inx 2409 1 This this DT cord-010092-uftc8inx 2409 2 abolishes abolish VBZ cord-010092-uftc8inx 2409 3 erythroid erythroid NN cord-010092-uftc8inx 2409 4 Xg Xg NNP cord-010092-uftc8inx 2409 5 a a DT cord-010092-uftc8inx 2409 6 expression expression NN cord-010092-uftc8inx 2409 7 and and CC cord-010092-uftc8inx 2409 8 causes cause VBZ cord-010092-uftc8inx 2409 9 the the DT cord-010092-uftc8inx 2409 10 common common JJ cord-010092-uftc8inx 2409 11 Xg(a- xg(a- CD cord-010092-uftc8inx 2409 12 ) ) -RRB- cord-010092-uftc8inx 2409 13 red red JJ cord-010092-uftc8inx 2409 14 cell cell NN cord-010092-uftc8inx 2409 15 phenotype phenotype NN cord-010092-uftc8inx 2409 16 . . . cord-010092-uftc8inx 2410 1 However however RB cord-010092-uftc8inx 2410 2 , , , cord-010092-uftc8inx 2410 3 rare rare JJ cord-010092-uftc8inx 2410 4 individuals individual NNS cord-010092-uftc8inx 2410 5 who who WP cord-010092-uftc8inx 2410 6 produce produce VBP cord-010092-uftc8inx 2410 7 anti anti JJ cord-010092-uftc8inx 2410 8 - - NNP cord-010092-uftc8inx 2410 9 Xg Xg NNP cord-010092-uftc8inx 2410 10 a a DT cord-010092-uftc8inx 2410 11 can can MD cord-010092-uftc8inx 2410 12 not not RB cord-010092-uftc8inx 2410 13 be be VB cord-010092-uftc8inx 2410 14 accounted account VBN cord-010092-uftc8inx 2410 15 for for IN cord-010092-uftc8inx 2410 16 by by IN cord-010092-uftc8inx 2410 17 this this DT cord-010092-uftc8inx 2410 18 finding finding NN cord-010092-uftc8inx 2410 19 . . . cord-010092-uftc8inx 2411 1 We -PRON- PRP cord-010092-uftc8inx 2411 2 hypothesized hypothesize VBD cord-010092-uftc8inx 2411 3 that that IN cord-010092-uftc8inx 2411 4 a a DT cord-010092-uftc8inx 2411 5 structural structural JJ cord-010092-uftc8inx 2411 6 defect defect NN cord-010092-uftc8inx 2411 7 in in IN cord-010092-uftc8inx 2411 8 the the DT cord-010092-uftc8inx 2411 9 XG XG NNP cord-010092-uftc8inx 2411 10 coding coding NN cord-010092-uftc8inx 2411 11 region region NN cord-010092-uftc8inx 2411 12 causes cause VBZ cord-010092-uftc8inx 2411 13 the the DT cord-010092-uftc8inx 2411 14 true true JJ cord-010092-uftc8inx 2411 15 Xg Xg NNP cord-010092-uftc8inx 2411 16 null null JJ cord-010092-uftc8inx 2411 17 phenotype phenotype NN cord-010092-uftc8inx 2411 18 underlying underlie VBG cord-010092-uftc8inx 2411 19 anti anti NNP cord-010092-uftc8inx 2411 20 - - NNP cord-010092-uftc8inx 2411 21 Xg Xg NNP cord-010092-uftc8inx 2411 22 a a DT cord-010092-uftc8inx 2411 23 production production NN cord-010092-uftc8inx 2411 24 . . . cord-010092-uftc8inx 2412 1 Aims aim VBZ cord-010092-uftc8inx 2412 2 : : : cord-010092-uftc8inx 2412 3 We -PRON- PRP cord-010092-uftc8inx 2412 4 undertook undertake VBD cord-010092-uftc8inx 2412 5 to to TO cord-010092-uftc8inx 2412 6 determine determine VB cord-010092-uftc8inx 2412 7 a a DT cord-010092-uftc8inx 2412 8 genetic genetic JJ cord-010092-uftc8inx 2412 9 explanation explanation NN cord-010092-uftc8inx 2412 10 for for IN cord-010092-uftc8inx 2412 11 anti anti NNP cord-010092-uftc8inx 2412 12 - - NNP cord-010092-uftc8inx 2412 13 Xg Xg NNP cord-010092-uftc8inx 2412 14 a a DT cord-010092-uftc8inx 2412 15 production production NN cord-010092-uftc8inx 2412 16 . . . cord-010092-uftc8inx 2413 1 Methods method NNS cord-010092-uftc8inx 2413 2 : : : cord-010092-uftc8inx 2413 3 Genomic genomic JJ cord-010092-uftc8inx 2413 4 DNA dna NN cord-010092-uftc8inx 2413 5 ( ( -LRB- cord-010092-uftc8inx 2413 6 gDNA gdna NN cord-010092-uftc8inx 2413 7 ) ) -RRB- cord-010092-uftc8inx 2413 8 was be VBD cord-010092-uftc8inx 2413 9 extracted extract VBN cord-010092-uftc8inx 2413 10 from from IN cord-010092-uftc8inx 2413 11 two two CD cord-010092-uftc8inx 2413 12 whole whole JJ cord-010092-uftc8inx 2413 13 blood blood NN cord-010092-uftc8inx 2413 14 samples sample NNS cord-010092-uftc8inx 2413 15 and and CC cord-010092-uftc8inx 2413 16 cell cell NN cord-010092-uftc8inx 2413 17 - - HYPH cord-010092-uftc8inx 2413 18 free free JJ cord-010092-uftc8inx 2413 19 DNA dna NN cord-010092-uftc8inx 2413 20 ( ( -LRB- cord-010092-uftc8inx 2413 21 cfDNA cfDNA '' cord-010092-uftc8inx 2413 22 ) ) -RRB- cord-010092-uftc8inx 2413 23 from from IN cord-010092-uftc8inx 2413 24 13 13 CD cord-010092-uftc8inx 2413 25 archived archived JJ cord-010092-uftc8inx 2413 26 plasma plasma NN cord-010092-uftc8inx 2413 27 samples sample NNS cord-010092-uftc8inx 2413 28 from from IN cord-010092-uftc8inx 2413 29 donors donor NNS cord-010092-uftc8inx 2413 30 producing produce VBG cord-010092-uftc8inx 2413 31 anti anti NNP cord-010092-uftc8inx 2413 32 - - JJ cord-010092-uftc8inx 2413 33 Xg Xg NNP cord-010092-uftc8inx 2413 34 a a DT cord-010092-uftc8inx 2414 1 ; ; : cord-010092-uftc8inx 2414 2 one one PRP cord-010092-uftc8inx 2414 3 cfDNA cfdna UH cord-010092-uftc8inx 2414 4 sample sample NN cord-010092-uftc8inx 2414 5 was be VBD cord-010092-uftc8inx 2414 6 from from IN cord-010092-uftc8inx 2414 7 a a DT cord-010092-uftc8inx 2414 8 female female JJ cord-010092-uftc8inx 2414 9 donor donor NN cord-010092-uftc8inx 2414 10 and and CC cord-010092-uftc8inx 2414 11 the the DT cord-010092-uftc8inx 2414 12 rest rest NN cord-010092-uftc8inx 2414 13 from from IN cord-010092-uftc8inx 2414 14 males male NNS cord-010092-uftc8inx 2414 15 . . . cord-010092-uftc8inx 2415 1 Polymerase polymerase NN cord-010092-uftc8inx 2415 2 chain chain NN cord-010092-uftc8inx 2415 3 reaction reaction NN cord-010092-uftc8inx 2415 4 ( ( -LRB- cord-010092-uftc8inx 2415 5 PCR PCR NNP cord-010092-uftc8inx 2415 6 ) ) -RRB- cord-010092-uftc8inx 2415 7 experiments experiment NNS cord-010092-uftc8inx 2415 8 , , , cord-010092-uftc8inx 2415 9 Sanger Sanger NNP cord-010092-uftc8inx 2415 10 sequencing sequencing NN cord-010092-uftc8inx 2415 11 , , , cord-010092-uftc8inx 2415 12 and and CC cord-010092-uftc8inx 2415 13 database database NN cord-010092-uftc8inx 2415 14 searches search NNS cord-010092-uftc8inx 2415 15 were be VBD cord-010092-uftc8inx 2415 16 performed perform VBN cord-010092-uftc8inx 2415 17 to to TO cord-010092-uftc8inx 2415 18 identify identify VB cord-010092-uftc8inx 2415 19 and and CC cord-010092-uftc8inx 2415 20 confirm confirm VB cord-010092-uftc8inx 2415 21 the the DT cord-010092-uftc8inx 2415 22 deletion deletion NN cord-010092-uftc8inx 2415 23 . . . cord-010092-uftc8inx 2416 1 Aliquots Aliquots NNP cord-010092-uftc8inx 2416 2 of of IN cord-010092-uftc8inx 2416 3 gDNA gdna NN cord-010092-uftc8inx 2416 4 from from IN cord-010092-uftc8inx 2416 5 four four CD cord-010092-uftc8inx 2416 6 males male NNS cord-010092-uftc8inx 2416 7 reported report VBN cord-010092-uftc8inx 2416 8 to to TO cord-010092-uftc8inx 2416 9 carry carry VB cord-010092-uftc8inx 2416 10 a a DT cord-010092-uftc8inx 2416 11 similar similar JJ cord-010092-uftc8inx 2416 12 deletion deletion NN cord-010092-uftc8inx 2416 13 in in IN cord-010092-uftc8inx 2416 14 the the DT cord-010092-uftc8inx 2416 15 1000 1000 CD cord-010092-uftc8inx 2416 16 Genomes Genomes NNPS cord-010092-uftc8inx 2416 17 Project Project NNP cord-010092-uftc8inx 2416 18 were be VBD cord-010092-uftc8inx 2416 19 also also RB cord-010092-uftc8inx 2416 20 tested test VBN cord-010092-uftc8inx 2416 21 . . . cord-010092-uftc8inx 2417 1 Results result NNS cord-010092-uftc8inx 2417 2 : : : cord-010092-uftc8inx 2418 1 In in IN cord-010092-uftc8inx 2418 2 one one CD cord-010092-uftc8inx 2418 3 gDNA gdna NN cord-010092-uftc8inx 2418 4 sample sample NN cord-010092-uftc8inx 2418 5 , , , cord-010092-uftc8inx 2418 6 exon exon NN cord-010092-uftc8inx 2418 7 - - HYPH cord-010092-uftc8inx 2418 8 specific specific JJ cord-010092-uftc8inx 2418 9 PCR PCR NNP cord-010092-uftc8inx 2418 10 identified identify VBD cord-010092-uftc8inx 2418 11 a a DT cord-010092-uftc8inx 2418 12 deletion deletion NN cord-010092-uftc8inx 2418 13 involving involve VBG cord-010092-uftc8inx 2418 14 part part NN cord-010092-uftc8inx 2418 15 of of IN cord-010092-uftc8inx 2418 16 XG XG NNP cord-010092-uftc8inx 2418 17 and and CC cord-010092-uftc8inx 2418 18 the the DT cord-010092-uftc8inx 2418 19 downstream downstream JJ cord-010092-uftc8inx 2418 20 gene gene NN cord-010092-uftc8inx 2418 21 GYG2 GYG2 NNP cord-010092-uftc8inx 2418 22 . . . cord-010092-uftc8inx 2419 1 Database database NN cord-010092-uftc8inx 2419 2 searches search NNS cord-010092-uftc8inx 2419 3 indicated indicate VBD cord-010092-uftc8inx 2419 4 that that IN cord-010092-uftc8inx 2419 5 the the DT cord-010092-uftc8inx 2419 6 most most RBS cord-010092-uftc8inx 2419 7 likely likely JJ cord-010092-uftc8inx 2419 8 deletion deletion NN cord-010092-uftc8inx 2419 9 was be VBD cord-010092-uftc8inx 2419 10 the the DT cord-010092-uftc8inx 2419 11 infrequent infrequent JJ cord-010092-uftc8inx 2419 12 genomic genomic JJ cord-010092-uftc8inx 2419 13 structural structural JJ cord-010092-uftc8inx 2419 14 variant variant NN cord-010092-uftc8inx 2419 15 esv2662319 esv2662319 NN cord-010092-uftc8inx 2419 16 reported report VBN cord-010092-uftc8inx 2419 17 in in IN cord-010092-uftc8inx 2419 18 the the DT cord-010092-uftc8inx 2419 19 1000 1000 CD cord-010092-uftc8inx 2419 20 Genomes Genomes NNPS cord-010092-uftc8inx 2419 21 Project Project NNP cord-010092-uftc8inx 2419 22 . . . cord-010092-uftc8inx 2420 1 Further further JJ cord-010092-uftc8inx 2420 2 analyses analysis NNS cord-010092-uftc8inx 2420 3 with with IN cord-010092-uftc8inx 2420 4 a a DT cord-010092-uftc8inx 2420 5 short short JJ cord-010092-uftc8inx 2420 6 ( ( -LRB- cord-010092-uftc8inx 2420 7 714 714 NNP cord-010092-uftc8inx 2420 8 bp bp NNP cord-010092-uftc8inx 2420 9 ) ) -RRB- cord-010092-uftc8inx 2420 10 and and CC cord-010092-uftc8inx 2420 11 a a DT cord-010092-uftc8inx 2420 12 long long JJ cord-010092-uftc8inx 2420 13 ( ( -LRB- cord-010092-uftc8inx 2420 14 3555 3555 CD cord-010092-uftc8inx 2420 15 bp bp NNP cord-010092-uftc8inx 2420 16 ) ) -RRB- cord-010092-uftc8inx 2420 17 PCR PCR NNP cord-010092-uftc8inx 2420 18 amplicon amplicon NN cord-010092-uftc8inx 2420 19 across across IN cord-010092-uftc8inx 2420 20 the the DT cord-010092-uftc8inx 2420 21 suspected suspect VBN cord-010092-uftc8inx 2420 22 breakpoint breakpoint NN cord-010092-uftc8inx 2420 23 determined determine VBD cord-010092-uftc8inx 2420 24 that that IN cord-010092-uftc8inx 2420 25 this this DT cord-010092-uftc8inx 2420 26 deletion deletion NN cord-010092-uftc8inx 2420 27 was be VBD cord-010092-uftc8inx 2420 28 approximately approximately RB cord-010092-uftc8inx 2420 29 114 114 CD cord-010092-uftc8inx 2420 30 kb kb NNS cord-010092-uftc8inx 2420 31 and and CC cord-010092-uftc8inx 2420 32 corresponded correspond VBD cord-010092-uftc8inx 2420 33 well well RB cord-010092-uftc8inx 2420 34 with with IN cord-010092-uftc8inx 2420 35 esv2662319 esv2662319 NN cord-010092-uftc8inx 2420 36 . . . cord-010092-uftc8inx 2421 1 This this DT cord-010092-uftc8inx 2421 2 finding finding NN cord-010092-uftc8inx 2421 3 was be VBD cord-010092-uftc8inx 2421 4 confirmed confirm VBN cord-010092-uftc8inx 2421 5 in in IN cord-010092-uftc8inx 2421 6 the the DT cord-010092-uftc8inx 2421 7 second second JJ cord-010092-uftc8inx 2421 8 gDNA gdna NN cord-010092-uftc8inx 2421 9 sample sample NN cord-010092-uftc8inx 2421 10 . . . cord-010092-uftc8inx 2422 1 Given give VBN cord-010092-uftc8inx 2422 2 the the DT cord-010092-uftc8inx 2422 3 rarity rarity NN cord-010092-uftc8inx 2422 4 of of IN cord-010092-uftc8inx 2422 5 anti anti JJ cord-010092-uftc8inx 2422 6 - - JJ cord-010092-uftc8inx 2422 7 Xg Xg NNP cord-010092-uftc8inx 2422 8 a a DT cord-010092-uftc8inx 2422 9 producers producer NNS cord-010092-uftc8inx 2422 10 , , , cord-010092-uftc8inx 2422 11 we -PRON- PRP cord-010092-uftc8inx 2422 12 decided decide VBD cord-010092-uftc8inx 2422 13 to to TO cord-010092-uftc8inx 2422 14 test test VB cord-010092-uftc8inx 2422 15 for for IN cord-010092-uftc8inx 2422 16 the the DT cord-010092-uftc8inx 2422 17 same same JJ cord-010092-uftc8inx 2422 18 deletion deletion NN cord-010092-uftc8inx 2422 19 in in IN cord-010092-uftc8inx 2422 20 cfDNA cfdna RB cord-010092-uftc8inx 2422 21 extracted extract VBN cord-010092-uftc8inx 2422 22 from from IN cord-010092-uftc8inx 2422 23 old old JJ cord-010092-uftc8inx 2422 24 archived archived JJ cord-010092-uftc8inx 2422 25 plasma plasma NN cord-010092-uftc8inx 2422 26 samples sample NNS cord-010092-uftc8inx 2422 27 . . . cord-010092-uftc8inx 2423 1 Of of IN cord-010092-uftc8inx 2423 2 the the DT cord-010092-uftc8inx 2423 3 13 13 CD cord-010092-uftc8inx 2423 4 cfDNA cfdna NN cord-010092-uftc8inx 2423 5 samples sample NNS cord-010092-uftc8inx 2423 6 , , , cord-010092-uftc8inx 2423 7 poor poor JJ cord-010092-uftc8inx 2423 8 quality quality NN cord-010092-uftc8inx 2423 9 in in IN cord-010092-uftc8inx 2423 10 four four CD cord-010092-uftc8inx 2423 11 samples sample NNS cord-010092-uftc8inx 2423 12 prevented prevent VBD cord-010092-uftc8inx 2423 13 amplification amplification NN cord-010092-uftc8inx 2423 14 even even RB cord-010092-uftc8inx 2423 15 from from IN cord-010092-uftc8inx 2423 16 control control NN cord-010092-uftc8inx 2423 17 reactions reaction NNS cord-010092-uftc8inx 2423 18 and and CC cord-010092-uftc8inx 2423 19 one one CD cord-010092-uftc8inx 2423 20 was be VBD cord-010092-uftc8inx 2423 21 contaminated contaminate VBN cord-010092-uftc8inx 2423 22 with with IN cord-010092-uftc8inx 2423 23 bacterial bacterial JJ cord-010092-uftc8inx 2423 24 DNA dna NN cord-010092-uftc8inx 2423 25 . . . cord-010092-uftc8inx 2424 1 In in IN cord-010092-uftc8inx 2424 2 the the DT cord-010092-uftc8inx 2424 3 remaining remain VBG cord-010092-uftc8inx 2424 4 nine nine CD cord-010092-uftc8inx 2424 5 samples sample NNS cord-010092-uftc8inx 2424 6 , , , cord-010092-uftc8inx 2424 7 eight eight CD cord-010092-uftc8inx 2424 8 could could MD cord-010092-uftc8inx 2424 9 be be VB cord-010092-uftc8inx 2424 10 amplified amplify VBN cord-010092-uftc8inx 2424 11 for for IN cord-010092-uftc8inx 2424 12 the the DT cord-010092-uftc8inx 2424 13 deletion deletion NN cord-010092-uftc8inx 2424 14 - - HYPH cord-010092-uftc8inx 2424 15 specific specific JJ cord-010092-uftc8inx 2424 16 714-bp 714-bp CD cord-010092-uftc8inx 2424 17 short short JJ cord-010092-uftc8inx 2424 18 amplicon amplicon NN cord-010092-uftc8inx 2424 19 while while IN cord-010092-uftc8inx 2424 20 one one CD cord-010092-uftc8inx 2424 21 was be VBD cord-010092-uftc8inx 2424 22 negative negative JJ cord-010092-uftc8inx 2424 23 for for IN cord-010092-uftc8inx 2424 24 the the DT cord-010092-uftc8inx 2424 25 deletion deletion NN cord-010092-uftc8inx 2424 26 . . . cord-010092-uftc8inx 2425 1 Sanger Sanger NNP cord-010092-uftc8inx 2425 2 sequencing sequencing NN cord-010092-uftc8inx 2425 3 of of IN cord-010092-uftc8inx 2425 4 the the DT cord-010092-uftc8inx 2425 5 amplicons amplicon NNS cord-010092-uftc8inx 2425 6 revealed reveal VBD cord-010092-uftc8inx 2425 7 a a DT cord-010092-uftc8inx 2425 8 heterogeneous heterogeneous JJ cord-010092-uftc8inx 2425 9 repetitive repetitive JJ cord-010092-uftc8inx 2425 10 DNA dna NN cord-010092-uftc8inx 2425 11 element element NN cord-010092-uftc8inx 2425 12 , , , cord-010092-uftc8inx 2425 13 LTR6B LTR6B '' cord-010092-uftc8inx 2425 14 , , , cord-010092-uftc8inx 2425 15 hinting hint VBG cord-010092-uftc8inx 2425 16 at at IN cord-010092-uftc8inx 2425 17 a a DT cord-010092-uftc8inx 2425 18 previously previously RB cord-010092-uftc8inx 2425 19 - - HYPH cord-010092-uftc8inx 2425 20 reported report VBN cord-010092-uftc8inx 2425 21 recombination recombination NN cord-010092-uftc8inx 2425 22 event event NN cord-010092-uftc8inx 2425 23 . . . cord-010092-uftc8inx 2426 1 This this DT cord-010092-uftc8inx 2426 2 deletion deletion NN cord-010092-uftc8inx 2426 3 was be VBD cord-010092-uftc8inx 2426 4 not not RB cord-010092-uftc8inx 2426 5 detected detect VBN cord-010092-uftc8inx 2426 6 in in IN cord-010092-uftc8inx 2426 7 the the DT cord-010092-uftc8inx 2426 8 samples sample NNS cord-010092-uftc8inx 2426 9 from from IN cord-010092-uftc8inx 2426 10 the the DT cord-010092-uftc8inx 2426 11 1000 1000 CD cord-010092-uftc8inx 2426 12 Genomes Genomes NNPS cord-010092-uftc8inx 2426 13 Project Project NNP cord-010092-uftc8inx 2426 14 which which WDT cord-010092-uftc8inx 2426 15 reiterates reiterate VBZ cord-010092-uftc8inx 2426 16 the the DT cord-010092-uftc8inx 2426 17 previously previously RB cord-010092-uftc8inx 2426 18 identified identify VBN cord-010092-uftc8inx 2426 19 deficiency deficiency NN cord-010092-uftc8inx 2426 20 in in IN cord-010092-uftc8inx 2426 21 data data NN cord-010092-uftc8inx 2426 22 interpretation interpretation NN cord-010092-uftc8inx 2426 23 and and CC cord-010092-uftc8inx 2426 24 reporting report VBG cord-010092-uftc8inx 2426 25 for for IN cord-010092-uftc8inx 2426 26 deletions deletion NNS cord-010092-uftc8inx 2426 27 . . . cord-010092-uftc8inx 2427 1 Summary Summary NNP cord-010092-uftc8inx 2427 2 / / SYM cord-010092-uftc8inx 2427 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 2427 4 : : : cord-010092-uftc8inx 2428 1 A a DT cord-010092-uftc8inx 2428 2 large large JJ cord-010092-uftc8inx 2428 3 deletion deletion NN cord-010092-uftc8inx 2428 4 disrupting disrupt VBG cord-010092-uftc8inx 2428 5 the the DT cord-010092-uftc8inx 2428 6 XG XG NNP cord-010092-uftc8inx 2428 7 and and CC cord-010092-uftc8inx 2428 8 GYG2 GYG2 NNP cord-010092-uftc8inx 2428 9 genes gene NNS cord-010092-uftc8inx 2428 10 accounts account VBZ cord-010092-uftc8inx 2428 11 for for IN cord-010092-uftc8inx 2428 12 the the DT cord-010092-uftc8inx 2428 13 Xg Xg NNP cord-010092-uftc8inx 2428 14 null null NN cord-010092-uftc8inx 2428 15 phenotype phenotype NN cord-010092-uftc8inx 2428 16 underlying underlie VBG cord-010092-uftc8inx 2428 17 the the DT cord-010092-uftc8inx 2428 18 majority majority NN cord-010092-uftc8inx 2428 19 ( ( -LRB- cord-010092-uftc8inx 2428 20 10 10 CD cord-010092-uftc8inx 2428 21 of of IN cord-010092-uftc8inx 2428 22 11 11 CD cord-010092-uftc8inx 2428 23 ) ) -RRB- cord-010092-uftc8inx 2428 24 of of IN cord-010092-uftc8inx 2428 25 anti anti JJ cord-010092-uftc8inx 2428 26 - - NNP cord-010092-uftc8inx 2428 27 Xg Xg NNP cord-010092-uftc8inx 2428 28 a a DT cord-010092-uftc8inx 2428 29 makers maker NNS cord-010092-uftc8inx 2428 30 . . . cord-010092-uftc8inx 2429 1 One one CD cord-010092-uftc8inx 2429 2 sample sample NN cord-010092-uftc8inx 2429 3 remained remain VBD cord-010092-uftc8inx 2429 4 unexplained unexplained JJ cord-010092-uftc8inx 2429 5 , , , cord-010092-uftc8inx 2429 6 indicating indicate VBG cord-010092-uftc8inx 2429 7 further further JJ cord-010092-uftc8inx 2429 8 heterogeneity heterogeneity NN cord-010092-uftc8inx 2429 9 to to TO cord-010092-uftc8inx 2429 10 be be VB cord-010092-uftc8inx 2429 11 explored explore VBN cord-010092-uftc8inx 2429 12 . . . cord-010092-uftc8inx 2430 1 Our -PRON- PRP$ cord-010092-uftc8inx 2430 2 data datum NNS cord-010092-uftc8inx 2430 3 help help NN cord-010092-uftc8inx 2430 4 to to TO cord-010092-uftc8inx 2430 5 explain explain VB cord-010092-uftc8inx 2430 6 why why WRB cord-010092-uftc8inx 2430 7 anti anti JJ cord-010092-uftc8inx 2430 8 - - JJ cord-010092-uftc8inx 2430 9 Xg Xg NNP cord-010092-uftc8inx 2430 10 a a DT cord-010092-uftc8inx 2430 11 production production NN cord-010092-uftc8inx 2430 12 is be VBZ cord-010092-uftc8inx 2430 13 rare rare JJ cord-010092-uftc8inx 2430 14 and and CC cord-010092-uftc8inx 2430 15 has have VBZ cord-010092-uftc8inx 2430 16 primarily primarily RB cord-010092-uftc8inx 2430 17 been be VBN cord-010092-uftc8inx 2430 18 reported report VBN cord-010092-uftc8inx 2430 19 in in IN cord-010092-uftc8inx 2430 20 men man NNS cord-010092-uftc8inx 2430 21 . . . cord-010092-uftc8inx 2431 1 Background background NN cord-010092-uftc8inx 2431 2 : : : cord-010092-uftc8inx 2432 1 S S NNP cord-010092-uftc8inx 2432 2 and and CC cord-010092-uftc8inx 2432 3 s s POS cord-010092-uftc8inx 2432 4 antigens antigen NNS cord-010092-uftc8inx 2432 5 encoded encode VBN cord-010092-uftc8inx 2432 6 by by IN cord-010092-uftc8inx 2432 7 GYPB GYPB NNP cord-010092-uftc8inx 2432 8 differ differ VBP cord-010092-uftc8inx 2432 9 by by IN cord-010092-uftc8inx 2432 10 one one CD cord-010092-uftc8inx 2432 11 nucleotide nucleotide NN cord-010092-uftc8inx 2432 12 ( ( -LRB- cord-010092-uftc8inx 2432 13 nt nt RB cord-010092-uftc8inx 2432 14 ) ) -RRB- cord-010092-uftc8inx 2432 15 , , . cord-010092-uftc8inx 2433 1 c.143C c.143C NNP cord-010092-uftc8inx 2434 1 > > XX cord-010092-uftc8inx 2435 1 T T NNP cord-010092-uftc8inx 2435 2 , , , cord-010092-uftc8inx 2435 3 p. p. NN cord-010092-uftc8inx 2436 1 Thr48Met Thr48Met NNP cord-010092-uftc8inx 2436 2 . . . cord-010092-uftc8inx 2437 1 Two two CD cord-010092-uftc8inx 2437 2 different different JJ cord-010092-uftc8inx 2437 3 genetic genetic JJ cord-010092-uftc8inx 2437 4 backgrounds background NNS cord-010092-uftc8inx 2437 5 are be VBP cord-010092-uftc8inx 2437 6 associated associate VBN cord-010092-uftc8inx 2437 7 with with IN cord-010092-uftc8inx 2437 8 silencing silencing NN cord-010092-uftc8inx 2437 9 of of IN cord-010092-uftc8inx 2437 10 S S NNP cord-010092-uftc8inx 2437 11 antigen antigen NN cord-010092-uftc8inx 2437 12 and and CC cord-010092-uftc8inx 2437 13 a a DT cord-010092-uftc8inx 2437 14 U+ u+ JJ cord-010092-uftc8inx 2437 15 w w NN cord-010092-uftc8inx 2437 16 phenotype phenotype NN cord-010092-uftc8inx 2437 17 . . . cord-010092-uftc8inx 2438 1 These these DT cord-010092-uftc8inx 2438 2 include include VBP cord-010092-uftc8inx 2438 3 the the DT cord-010092-uftc8inx 2438 4 nt nt RB cord-010092-uftc8inx 2438 5 change change VB cord-010092-uftc8inx 2438 6 c.230C c.230C NNP cord-010092-uftc8inx 2438 7 > > XX cord-010092-uftc8inx 2438 8 T t NN cord-010092-uftc8inx 2438 9 ( ( -LRB- cord-010092-uftc8inx 2438 10 p p NN cord-010092-uftc8inx 2438 11 . . . cord-010092-uftc8inx 2438 12 Thr77Met Thr77Met NNP cord-010092-uftc8inx 2438 13 ) ) -RRB- cord-010092-uftc8inx 2438 14 causing cause VBG cord-010092-uftc8inx 2438 15 partial partial JJ cord-010092-uftc8inx 2438 16 exon exon NN cord-010092-uftc8inx 2438 17 skipping skip VBG cord-010092-uftc8inx 2438 18 and and CC cord-010092-uftc8inx 2438 19 designated designate VBN cord-010092-uftc8inx 2438 20 GYBP*03N.01 GYBP*03N.01 NNP cord-010092-uftc8inx 2438 21 ( ( -LRB- cord-010092-uftc8inx 2438 22 GYPB*NY GYPB*NY NNP cord-010092-uftc8inx 2438 23 ) ) -RRB- cord-010092-uftc8inx 2438 24 and and CC cord-010092-uftc8inx 2439 1 c.270 c.270 NNP cord-010092-uftc8inx 2439 2 + + SYM cord-010092-uftc8inx 2439 3 5 5 CD cord-010092-uftc8inx 2439 4 G g NN cord-010092-uftc8inx 2440 1 > > XX cord-010092-uftc8inx 2441 1 T T NNP cord-010092-uftc8inx 2441 2 , , , cord-010092-uftc8inx 2441 3 an an DT cord-010092-uftc8inx 2441 4 intron intron NN cord-010092-uftc8inx 2441 5 change change NN cord-010092-uftc8inx 2441 6 causing cause VBG cord-010092-uftc8inx 2441 7 complete complete JJ cord-010092-uftc8inx 2441 8 skipping skipping NN cord-010092-uftc8inx 2441 9 of of IN cord-010092-uftc8inx 2441 10 exon exon NN cord-010092-uftc8inx 2441 11 5 5 CD cord-010092-uftc8inx 2441 12 , , , cord-010092-uftc8inx 2441 13 designated designate VBN cord-010092-uftc8inx 2441 14 GYPB*03N.03 gypb*03n.03 NN cord-010092-uftc8inx 2441 15 ( ( -LRB- cord-010092-uftc8inx 2441 16 GYPB*P2 GYPB*P2 NNP cord-010092-uftc8inx 2441 17 ) ) -RRB- cord-010092-uftc8inx 2441 18 . . . cord-010092-uftc8inx 2442 1 Aims aim NNS cord-010092-uftc8inx 2442 2 : : : cord-010092-uftc8inx 2442 3 Samples sample NNS cord-010092-uftc8inx 2442 4 from from IN cord-010092-uftc8inx 2442 5 three three CD cord-010092-uftc8inx 2442 6 individuals individual NNS cord-010092-uftc8inx 2442 7 , , , cord-010092-uftc8inx 2442 8 a a DT cord-010092-uftc8inx 2442 9 previously previously RB cord-010092-uftc8inx 2442 10 transfused transfuse VBN cord-010092-uftc8inx 2442 11 African african JJ cord-010092-uftc8inx 2442 12 American american JJ cord-010092-uftc8inx 2442 13 sickle sickle NN cord-010092-uftc8inx 2442 14 cell cell NN cord-010092-uftc8inx 2442 15 patient patient NN cord-010092-uftc8inx 2442 16 ( ( -LRB- cord-010092-uftc8inx 2442 17 P1 P1 NNP cord-010092-uftc8inx 2442 18 ) ) -RRB- cord-010092-uftc8inx 2442 19 , , , cord-010092-uftc8inx 2442 20 a a DT cord-010092-uftc8inx 2442 21 blood blood NN cord-010092-uftc8inx 2442 22 donor donor NN cord-010092-uftc8inx 2442 23 of of IN cord-010092-uftc8inx 2442 24 unknown unknown JJ cord-010092-uftc8inx 2442 25 ethnicity ethnicity NN cord-010092-uftc8inx 2442 26 ( ( -LRB- cord-010092-uftc8inx 2442 27 P2 P2 NNP cord-010092-uftc8inx 2442 28 ) ) -RRB- cord-010092-uftc8inx 2442 29 , , , cord-010092-uftc8inx 2442 30 and and CC cord-010092-uftc8inx 2442 31 an an DT cord-010092-uftc8inx 2442 32 African african JJ cord-010092-uftc8inx 2442 33 American american JJ cord-010092-uftc8inx 2442 34 patient patient NN cord-010092-uftc8inx 2442 35 ( ( -LRB- cord-010092-uftc8inx 2442 36 P3 P3 NNP cord-010092-uftc8inx 2442 37 ) ) -RRB- cord-010092-uftc8inx 2443 1 ( ( -LRB- cord-010092-uftc8inx 2443 2 Lapadat Lapadat NNP cord-010092-uftc8inx 2443 3 R. R. NNP cord-010092-uftc8inx 2443 4 2014 2014 CD cord-010092-uftc8inx 2443 5 AABB AABB NNP cord-010092-uftc8inx 2443 6 abstract abstract NN cord-010092-uftc8inx 2443 7 ) ) -RRB- cord-010092-uftc8inx 2443 8 were be VBD cord-010092-uftc8inx 2443 9 investigated investigate VBN cord-010092-uftc8inx 2443 10 for for IN cord-010092-uftc8inx 2443 11 discrepant discrepant JJ cord-010092-uftc8inx 2443 12 serologic serologic NN cord-010092-uftc8inx 2443 13 and and CC cord-010092-uftc8inx 2443 14 molecular molecular JJ cord-010092-uftc8inx 2443 15 results result NNS cord-010092-uftc8inx 2443 16 when when WRB cord-010092-uftc8inx 2443 17 determining determine VBG cord-010092-uftc8inx 2443 18 S S NNP cord-010092-uftc8inx 2443 19 and and CC cord-010092-uftc8inx 2443 20 s s POS cord-010092-uftc8inx 2443 21 phenotype phenotype NN cord-010092-uftc8inx 2443 22 . . . cord-010092-uftc8inx 2444 1 Methods method NNS cord-010092-uftc8inx 2444 2 : : : cord-010092-uftc8inx 2445 1 Standard standard JJ cord-010092-uftc8inx 2445 2 methods method NNS cord-010092-uftc8inx 2445 3 were be VBD cord-010092-uftc8inx 2445 4 used use VBN cord-010092-uftc8inx 2445 5 for for IN cord-010092-uftc8inx 2445 6 RBC RBC NNP cord-010092-uftc8inx 2445 7 typing type VBG cord-010092-uftc8inx 2445 8 with with IN cord-010092-uftc8inx 2445 9 licensed licensed JJ cord-010092-uftc8inx 2445 10 S S NNP cord-010092-uftc8inx 2445 11 and and CC cord-010092-uftc8inx 2445 12 s s POS cord-010092-uftc8inx 2445 13 reagents reagent NNS cord-010092-uftc8inx 2445 14 and and CC cord-010092-uftc8inx 2445 15 RBCs rbc NNS cord-010092-uftc8inx 2445 16 from from IN cord-010092-uftc8inx 2445 17 donor donor NN cord-010092-uftc8inx 2445 18 P2 P2 NNP cord-010092-uftc8inx 2445 19 were be VBD cord-010092-uftc8inx 2445 20 also also RB cord-010092-uftc8inx 2445 21 tested test VBN cord-010092-uftc8inx 2445 22 with with IN cord-010092-uftc8inx 2445 23 monoclonal monoclonal JJ cord-010092-uftc8inx 2445 24 and and CC cord-010092-uftc8inx 2445 25 polyclonal polyclonal JJ cord-010092-uftc8inx 2445 26 anti anti NNP cord-010092-uftc8inx 2445 27 - - NNP cord-010092-uftc8inx 2445 28 S s JJ cord-010092-uftc8inx 2445 29 and and CC cord-010092-uftc8inx 2445 30 anti anti NNS cord-010092-uftc8inx 2445 31 - - NN cord-010092-uftc8inx 2445 32 s s NN cord-010092-uftc8inx 2445 33 . . . cord-010092-uftc8inx 2446 1 DNA DNA NNP cord-010092-uftc8inx 2446 2 was be VBD cord-010092-uftc8inx 2446 3 isolated isolate VBN cord-010092-uftc8inx 2446 4 from from IN cord-010092-uftc8inx 2446 5 WBCs wbc NNS cord-010092-uftc8inx 2446 6 and and CC cord-010092-uftc8inx 2446 7 HEA HEA NNP cord-010092-uftc8inx 2446 8 PreciseType PreciseType NNP cord-010092-uftc8inx 2446 9 performed perform VBN cord-010092-uftc8inx 2446 10 on on IN cord-010092-uftc8inx 2446 11 P1 P1 NNP cord-010092-uftc8inx 2446 12 and and CC cord-010092-uftc8inx 2446 13 P2 P2 NNP cord-010092-uftc8inx 2446 14 . . . cord-010092-uftc8inx 2447 1 P1 P1 NNP cord-010092-uftc8inx 2447 2 was be VBD cord-010092-uftc8inx 2447 3 also also RB cord-010092-uftc8inx 2447 4 tested test VBN cord-010092-uftc8inx 2447 5 by by IN cord-010092-uftc8inx 2447 6 GYPB*S GYPB*S NNP cord-010092-uftc8inx 2447 7 / / SYM cord-010092-uftc8inx 2447 8 s s POS cord-010092-uftc8inx 2447 9 AS AS NNP cord-010092-uftc8inx 2447 10 - - HYPH cord-010092-uftc8inx 2447 11 PCR PCR NNP cord-010092-uftc8inx 2447 12 , , , cord-010092-uftc8inx 2447 13 exon exon NN cord-010092-uftc8inx 2447 14 5 5 CD cord-010092-uftc8inx 2447 15 PCR PCR NNP cord-010092-uftc8inx 2447 16 - - HYPH cord-010092-uftc8inx 2447 17 RFLP RFLP NNP cord-010092-uftc8inx 2447 18 for for IN cord-010092-uftc8inx 2447 19 c.270 c.270 NNP cord-010092-uftc8inx 2447 20 + + SYM cord-010092-uftc8inx 2447 21 5 5 CD cord-010092-uftc8inx 2447 22 G g NN cord-010092-uftc8inx 2448 1 > > XX cord-010092-uftc8inx 2449 1 T T NNP cord-010092-uftc8inx 2449 2 and and CC cord-010092-uftc8inx 2449 3 AS AS NNP cord-010092-uftc8inx 2449 4 - - HYPH cord-010092-uftc8inx 2449 5 PCR PCR NNP cord-010092-uftc8inx 2449 6 for for IN cord-010092-uftc8inx 2449 7 c.230C c.230C NNP cord-010092-uftc8inx 2450 1 > > XX cord-010092-uftc8inx 2451 1 T. T. NNP cord-010092-uftc8inx 2451 2 P3 P3 NNP cord-010092-uftc8inx 2451 3 was be VBD cord-010092-uftc8inx 2451 4 tested test VBN cord-010092-uftc8inx 2451 5 for for IN cord-010092-uftc8inx 2451 6 GYPB*S GYPB*S NNP cord-010092-uftc8inx 2451 7 / / SYM cord-010092-uftc8inx 2451 8 s s NNP cord-010092-uftc8inx 2451 9 and and CC cord-010092-uftc8inx 2451 10 c.230 c.230 NNP cord-010092-uftc8inx 2451 11 C C NNP cord-010092-uftc8inx 2452 1 > > XX cord-010092-uftc8inx 2453 1 T T NNP cord-010092-uftc8inx 2453 2 and and CC cord-010092-uftc8inx 2453 3 c.270 c.270 NNP cord-010092-uftc8inx 2453 4 + + SYM cord-010092-uftc8inx 2453 5 5 5 CD cord-010092-uftc8inx 2453 6 G g NN cord-010092-uftc8inx 2454 1 > > XX cord-010092-uftc8inx 2455 1 T T NNP cord-010092-uftc8inx 2455 2 changes change NNS cord-010092-uftc8inx 2455 3 by by IN cord-010092-uftc8inx 2455 4 a a DT cord-010092-uftc8inx 2455 5 real real JJ cord-010092-uftc8inx 2455 6 - - HYPH cord-010092-uftc8inx 2455 7 time time NN cord-010092-uftc8inx 2455 8 PCR PCR NNP cord-010092-uftc8inx 2455 9 - - HYPH cord-010092-uftc8inx 2455 10 fluorogenic fluorogenic NNP cord-010092-uftc8inx 2455 11 5 5 CD cord-010092-uftc8inx 2455 12 ' ' '' cord-010092-uftc8inx 2455 13 nuclease nuclease NN cord-010092-uftc8inx 2455 14 TaqMan TaqMan NNP cord-010092-uftc8inx 2455 15 chemistry chemistry NN cord-010092-uftc8inx 2455 16 . . . cord-010092-uftc8inx 2456 1 For for IN cord-010092-uftc8inx 2456 2 all all DT cord-010092-uftc8inx 2456 3 , , , cord-010092-uftc8inx 2456 4 GYPB GYPB NNP cord-010092-uftc8inx 2456 5 exons exon NNS cord-010092-uftc8inx 2456 6 1 1 CD cord-010092-uftc8inx 2456 7 - - SYM cord-010092-uftc8inx 2456 8 6 6 CD cord-010092-uftc8inx 2456 9 were be VBD cord-010092-uftc8inx 2456 10 amplified amplify VBN cord-010092-uftc8inx 2456 11 and and CC cord-010092-uftc8inx 2456 12 Sanger Sanger NNP cord-010092-uftc8inx 2456 13 sequenced sequence VBD cord-010092-uftc8inx 2456 14 and and CC cord-010092-uftc8inx 2456 15 aligned align VBN cord-010092-uftc8inx 2456 16 to to IN cord-010092-uftc8inx 2456 17 consensus consensus NN cord-010092-uftc8inx 2456 18 using use VBG cord-010092-uftc8inx 2456 19 Clustal Clustal NNP cord-010092-uftc8inx 2456 20 X. X. NNP cord-010092-uftc8inx 2456 21 Results result NNS cord-010092-uftc8inx 2456 22 : : : cord-010092-uftc8inx 2456 23 RBCs rbc NNS cord-010092-uftc8inx 2456 24 of of IN cord-010092-uftc8inx 2456 25 all all DT cord-010092-uftc8inx 2456 26 three three CD cord-010092-uftc8inx 2456 27 probands proband NNS cord-010092-uftc8inx 2456 28 typed type VBD cord-010092-uftc8inx 2456 29 S S NNP cord-010092-uftc8inx 2456 30 - - : cord-010092-uftc8inx 2456 31 and and CC cord-010092-uftc8inx 2456 32 strongly strongly RB cord-010092-uftc8inx 2456 33 s+ s+ NNP cord-010092-uftc8inx 2456 34 while while IN cord-010092-uftc8inx 2456 35 DNA DNA NNP cord-010092-uftc8inx 2456 36 testing testing NN cord-010092-uftc8inx 2456 37 indicated indicate VBD cord-010092-uftc8inx 2457 1 c.143T c.143T NNP cord-010092-uftc8inx 2457 2 / / SYM cord-010092-uftc8inx 2457 3 C C NNP cord-010092-uftc8inx 2457 4 ( ( -LRB- cord-010092-uftc8inx 2457 5 GYPB*S GYPB*S NNP cord-010092-uftc8inx 2457 6 / / SYM cord-010092-uftc8inx 2457 7 s s NN cord-010092-uftc8inx 2457 8 ) ) -RRB- cord-010092-uftc8inx 2457 9 . . . cord-010092-uftc8inx 2458 1 Assay assay NN cord-010092-uftc8inx 2458 2 for for IN cord-010092-uftc8inx 2458 3 the the DT cord-010092-uftc8inx 2458 4 two two CD cord-010092-uftc8inx 2458 5 common common JJ cord-010092-uftc8inx 2458 6 GYPB*S gypb*s CD cord-010092-uftc8inx 2458 7 silenced silence VBN cord-010092-uftc8inx 2458 8 alleles allele NNS cord-010092-uftc8inx 2458 9 , , , cord-010092-uftc8inx 2459 1 c.230C c.230C NNP cord-010092-uftc8inx 2459 2 > > XX cord-010092-uftc8inx 2460 1 T T NNP cord-010092-uftc8inx 2460 2 and and CC cord-010092-uftc8inx 2460 3 c.270 c.270 NNP cord-010092-uftc8inx 2460 4 + + SYM cord-010092-uftc8inx 2460 5 5 5 CD cord-010092-uftc8inx 2460 6 G g NN cord-010092-uftc8inx 2461 1 > > XX cord-010092-uftc8inx 2462 1 T T NNP cord-010092-uftc8inx 2462 2 , , , cord-010092-uftc8inx 2462 3 indicated indicate VBD cord-010092-uftc8inx 2462 4 all all DT cord-010092-uftc8inx 2462 5 three three CD cord-010092-uftc8inx 2462 6 samples sample NNS cord-010092-uftc8inx 2462 7 had have VBD cord-010092-uftc8inx 2462 8 both both DT cord-010092-uftc8inx 2462 9 silencing silencing NN cord-010092-uftc8inx 2462 10 mutations mutation NNS cord-010092-uftc8inx 2462 11 previously previously RB cord-010092-uftc8inx 2462 12 reported report VBD cord-010092-uftc8inx 2462 13 to to TO cord-010092-uftc8inx 2462 14 be be VB cord-010092-uftc8inx 2462 15 independently independently RB cord-010092-uftc8inx 2462 16 associated associate VBN cord-010092-uftc8inx 2462 17 with with IN cord-010092-uftc8inx 2462 18 a a DT cord-010092-uftc8inx 2462 19 SÀU+ SÀU+ NNP cord-010092-uftc8inx 2462 20 w w NN cord-010092-uftc8inx 2462 21 phenotype phenotype NN cord-010092-uftc8inx 2462 22 . . . cord-010092-uftc8inx 2463 1 HEA HEA NNP cord-010092-uftc8inx 2463 2 PreciseType PreciseType NNP cord-010092-uftc8inx 2463 3 could could MD cord-010092-uftc8inx 2463 4 not not RB cord-010092-uftc8inx 2463 5 interpret interpret VB cord-010092-uftc8inx 2463 6 this this DT cord-010092-uftc8inx 2463 7 novel novel JJ cord-010092-uftc8inx 2463 8 allele allele NN cord-010092-uftc8inx 2463 9 combination combination NN cord-010092-uftc8inx 2463 10 and and CC cord-010092-uftc8inx 2463 11 indicated indicate VBD cord-010092-uftc8inx 2463 12 GYPB*s gypb*s JJ cord-010092-uftc8inx 2463 13 as as IN cord-010092-uftc8inx 2463 14 PV pv NN cord-010092-uftc8inx 2463 15 ( ( -LRB- cord-010092-uftc8inx 2463 16 possible possible JJ cord-010092-uftc8inx 2463 17 variant variant NN cord-010092-uftc8inx 2463 18 ) ) -RRB- cord-010092-uftc8inx 2463 19 . . . cord-010092-uftc8inx 2464 1 Samples sample NNS cord-010092-uftc8inx 2464 2 were be VBD cord-010092-uftc8inx 2464 3 confirmed confirm VBN cord-010092-uftc8inx 2464 4 to to TO cord-010092-uftc8inx 2464 5 be be VB cord-010092-uftc8inx 2464 6 heterozygous heterozygous JJ cord-010092-uftc8inx 2464 7 for for IN cord-010092-uftc8inx 2465 1 c.143C c.143C NNP cord-010092-uftc8inx 2465 2 / / SYM cord-010092-uftc8inx 2465 3 T T NNP cord-010092-uftc8inx 2465 4 , , , cord-010092-uftc8inx 2465 5 c.230C c.230C NNP cord-010092-uftc8inx 2465 6 / / SYM cord-010092-uftc8inx 2465 7 T T NNP cord-010092-uftc8inx 2465 8 and and CC cord-010092-uftc8inx 2465 9 c.270 c.270 NNP cord-010092-uftc8inx 2465 10 + + SYM cord-010092-uftc8inx 2465 11 5G 5g NN cord-010092-uftc8inx 2465 12 / / SYM cord-010092-uftc8inx 2465 13 T t NN cord-010092-uftc8inx 2465 14 by by IN cord-010092-uftc8inx 2465 15 exon exon JJ cord-010092-uftc8inx 2465 16 specific specific JJ cord-010092-uftc8inx 2465 17 sequencing sequencing NN cord-010092-uftc8inx 2465 18 and and CC cord-010092-uftc8inx 2465 19 AS AS NNP cord-010092-uftc8inx 2465 20 - - HYPH cord-010092-uftc8inx 2465 21 PCR PCR NNP cord-010092-uftc8inx 2465 22 , , , cord-010092-uftc8inx 2465 23 PCR PCR NNP cord-010092-uftc8inx 2465 24 - - HYPH cord-010092-uftc8inx 2465 25 RFLP rflp JJ cord-010092-uftc8inx 2465 26 and and CC cord-010092-uftc8inx 2465 27 real real JJ cord-010092-uftc8inx 2465 28 - - HYPH cord-010092-uftc8inx 2465 29 time time NN cord-010092-uftc8inx 2465 30 PCR PCR NNP cord-010092-uftc8inx 2465 31 . . . cord-010092-uftc8inx 2466 1 By by IN cord-010092-uftc8inx 2466 2 long long JJ cord-010092-uftc8inx 2466 3 range range NN cord-010092-uftc8inx 2466 4 sequencing sequencing NN cord-010092-uftc8inx 2466 5 of of IN cord-010092-uftc8inx 2466 6 GYPB GYPB NNP cord-010092-uftc8inx 2466 7 , , , cord-010092-uftc8inx 2466 8 all all DT cord-010092-uftc8inx 2466 9 three three CD cord-010092-uftc8inx 2466 10 were be VBD cord-010092-uftc8inx 2466 11 heterozygous heterozygous JJ cord-010092-uftc8inx 2466 12 c.59T c.59T NNS cord-010092-uftc8inx 2466 13 / / SYM cord-010092-uftc8inx 2466 14 G g NN cord-010092-uftc8inx 2466 15 and and CC cord-010092-uftc8inx 2466 16 c.60A c.60a NN cord-010092-uftc8inx 2466 17 / / SYM cord-010092-uftc8inx 2466 18 G g NN cord-010092-uftc8inx 2466 19 ( ( -LRB- cord-010092-uftc8inx 2466 20 p.20Leu p.20leu JJ cord-010092-uftc8inx 2466 21 / / SYM cord-010092-uftc8inx 2466 22 Trp Trp NNP cord-010092-uftc8inx 2466 23 ) ) -RRB- cord-010092-uftc8inx 2466 24 , , , cord-010092-uftc8inx 2466 25 c.67A c.67a NN cord-010092-uftc8inx 2466 26 / / SYM cord-010092-uftc8inx 2466 27 T T NNP cord-010092-uftc8inx 2466 28 ( ( -LRB- cord-010092-uftc8inx 2466 29 p.23Thr p.23Thr NNP cord-010092-uftc8inx 2466 30 / / SYM cord-010092-uftc8inx 2466 31 Ser Ser NNP cord-010092-uftc8inx 2466 32 ) ) -RRB- cord-010092-uftc8inx 2466 33 , , , cord-010092-uftc8inx 2466 34 c.71A c.71a NN cord-010092-uftc8inx 2466 35 / / SYM cord-010092-uftc8inx 2466 36 G g NN cord-010092-uftc8inx 2466 37 and and CC cord-010092-uftc8inx 2466 38 c.72G c.72G NNP cord-010092-uftc8inx 2466 39 / / SYM cord-010092-uftc8inx 2466 40 T T NNP cord-010092-uftc8inx 2466 41 ( ( -LRB- cord-010092-uftc8inx 2466 42 p.24Glu p.24Glu NNP cord-010092-uftc8inx 2466 43 / / SYM cord-010092-uftc8inx 2466 44 Gly Gly NNP cord-010092-uftc8inx 2466 45 ) ) -RRB- cord-010092-uftc8inx 2466 46 , , , cord-010092-uftc8inx 2466 47 c.143C c.143C NNP cord-010092-uftc8inx 2466 48 / / SYM cord-010092-uftc8inx 2466 49 T T NNP cord-010092-uftc8inx 2466 50 ( ( -LRB- cord-010092-uftc8inx 2466 51 s s NNP cord-010092-uftc8inx 2466 52 / / SYM cord-010092-uftc8inx 2466 53 S S NNP cord-010092-uftc8inx 2466 54 ) ) -RRB- cord-010092-uftc8inx 2466 55 , , , cord-010092-uftc8inx 2466 56 c.208G c.208G NNP cord-010092-uftc8inx 2466 57 / / SYM cord-010092-uftc8inx 2466 58 T T NNP cord-010092-uftc8inx 2466 59 ( ( -LRB- cord-010092-uftc8inx 2466 60 p.70Val p.70Val NNP cord-010092-uftc8inx 2466 61 / / SYM cord-010092-uftc8inx 2466 62 Leu Leu NNP cord-010092-uftc8inx 2466 63 ) ) -RRB- cord-010092-uftc8inx 2467 1 , , , cord-010092-uftc8inx 2467 2 c.230C c.230C NNP cord-010092-uftc8inx 2467 3 / / SYM cord-010092-uftc8inx 2467 4 T T NNP cord-010092-uftc8inx 2467 5 ( ( -LRB- cord-010092-uftc8inx 2467 6 p.77Thr p.77Thr NNP cord-010092-uftc8inx 2467 7 / / SYM cord-010092-uftc8inx 2467 8 Met Met NNP cord-010092-uftc8inx 2467 9 ) ) -RRB- cord-010092-uftc8inx 2467 10 , , , cord-010092-uftc8inx 2467 11 and and CC cord-010092-uftc8inx 2467 12 c.270 c.270 NNP cord-010092-uftc8inx 2467 13 + + SYM cord-010092-uftc8inx 2467 14 5G 5g NN cord-010092-uftc8inx 2467 15 / / SYM cord-010092-uftc8inx 2467 16 T. t. NN cord-010092-uftc8inx 2468 1 All all DT cord-010092-uftc8inx 2468 2 samples sample NNS cord-010092-uftc8inx 2468 3 were be VBD cord-010092-uftc8inx 2468 4 also also RB cord-010092-uftc8inx 2468 5 c.251G c.251G NNP cord-010092-uftc8inx 2468 6 / / SYM cord-010092-uftc8inx 2468 7 G G NNP cord-010092-uftc8inx 2468 8 ( ( -LRB- cord-010092-uftc8inx 2468 9 p.84Ser p.84Ser NNP cord-010092-uftc8inx 2468 10 ) ) -RRB- cord-010092-uftc8inx 2468 11 and and CC cord-010092-uftc8inx 2468 12 heterozygous heterozygous JJ cord-010092-uftc8inx 2468 13 for for IN cord-010092-uftc8inx 2468 14 several several JJ cord-010092-uftc8inx 2468 15 previously previously RB cord-010092-uftc8inx 2468 16 recognized recognize VBN cord-010092-uftc8inx 2468 17 silent silent JJ cord-010092-uftc8inx 2468 18 changes change NNS cord-010092-uftc8inx 2468 19 in in IN cord-010092-uftc8inx 2468 20 exon exon NN cord-010092-uftc8inx 2468 21 2 2 CD cord-010092-uftc8inx 2468 22 , , , cord-010092-uftc8inx 2468 23 c.87T c.87T NNP cord-010092-uftc8inx 2468 24 / / SYM cord-010092-uftc8inx 2468 25 C C NNP cord-010092-uftc8inx 2468 26 , , , cord-010092-uftc8inx 2468 27 c.96T c.96T NNP cord-010092-uftc8inx 2468 28 / / SYM cord-010092-uftc8inx 2468 29 C C NNP cord-010092-uftc8inx 2468 30 and and CC cord-010092-uftc8inx 2468 31 c.102A c.102A NNP cord-010092-uftc8inx 2468 32 / / SYM cord-010092-uftc8inx 2468 33 G. G. NNP cord-010092-uftc8inx 2469 1 Summary Summary NNP cord-010092-uftc8inx 2469 2 / / SYM cord-010092-uftc8inx 2469 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 2470 1 : : : cord-010092-uftc8inx 2470 2 We -PRON- PRP cord-010092-uftc8inx 2470 3 report report VBP cord-010092-uftc8inx 2470 4 a a DT cord-010092-uftc8inx 2470 5 novel novel NN cord-010092-uftc8inx 2470 6 silenced silence VBN cord-010092-uftc8inx 2470 7 GYPB*S gypb*s CD cord-010092-uftc8inx 2470 8 allele allele NN cord-010092-uftc8inx 2470 9 that that WDT cord-010092-uftc8inx 2470 10 can can MD cord-010092-uftc8inx 2470 11 confound confound VB cord-010092-uftc8inx 2470 12 GYPB gypb NN cord-010092-uftc8inx 2470 13 genotyping genotyping NN cord-010092-uftc8inx 2470 14 interpretation interpretation NN cord-010092-uftc8inx 2470 15 . . . cord-010092-uftc8inx 2471 1 The the DT cord-010092-uftc8inx 2471 2 allele allele NN cord-010092-uftc8inx 2471 3 was be VBD cord-010092-uftc8inx 2471 4 found find VBN cord-010092-uftc8inx 2471 5 in in IN cord-010092-uftc8inx 2471 6 three three CD cord-010092-uftc8inx 2471 7 probands proband NNS cord-010092-uftc8inx 2471 8 associated associate VBN cord-010092-uftc8inx 2471 9 with with IN cord-010092-uftc8inx 2471 10 a a DT cord-010092-uftc8inx 2471 11 SÀs+ SÀs+ NNP cord-010092-uftc8inx 2471 12 phenotype phenotype NN cord-010092-uftc8inx 2471 13 . . . cord-010092-uftc8inx 2472 1 In in IN cord-010092-uftc8inx 2472 2 these these DT cord-010092-uftc8inx 2472 3 samples sample NNS cord-010092-uftc8inx 2472 4 , , , cord-010092-uftc8inx 2472 5 two two CD cord-010092-uftc8inx 2472 6 changes change NNS cord-010092-uftc8inx 2472 7 previously previously RB cord-010092-uftc8inx 2472 8 reported report VBD cord-010092-uftc8inx 2472 9 to to TO cord-010092-uftc8inx 2472 10 be be VB cord-010092-uftc8inx 2472 11 inherited inherit VBN cord-010092-uftc8inx 2472 12 independently independently RB cord-010092-uftc8inx 2472 13 and and CC cord-010092-uftc8inx 2472 14 both both CC cord-010092-uftc8inx 2472 15 associated associate VBN cord-010092-uftc8inx 2472 16 with with IN cord-010092-uftc8inx 2472 17 silencing silencing NN cord-010092-uftc8inx 2472 18 of of IN cord-010092-uftc8inx 2472 19 S S NNP cord-010092-uftc8inx 2472 20 antigen antigen NN cord-010092-uftc8inx 2472 21 are be VBP cord-010092-uftc8inx 2472 22 carried carry VBN cord-010092-uftc8inx 2472 23 on on IN cord-010092-uftc8inx 2472 24 the the DT cord-010092-uftc8inx 2472 25 same same JJ cord-010092-uftc8inx 2472 26 allele allele NN cord-010092-uftc8inx 2472 27 . . . cord-010092-uftc8inx 2473 1 DNA dna NN cord-010092-uftc8inx 2473 2 - - HYPH cord-010092-uftc8inx 2473 3 based base VBN cord-010092-uftc8inx 2473 4 testing testing NN cord-010092-uftc8inx 2473 5 could could MD cord-010092-uftc8inx 2473 6 not not RB cord-010092-uftc8inx 2473 7 rule rule VB cord-010092-uftc8inx 2473 8 out out RP cord-010092-uftc8inx 2473 9 that that IN cord-010092-uftc8inx 2473 10 c.230 c.230 NNP cord-010092-uftc8inx 2473 11 T T NNP cord-010092-uftc8inx 2473 12 or or CC cord-010092-uftc8inx 2473 13 c.270 c.270 NNP cord-010092-uftc8inx 2473 14 + + SYM cord-010092-uftc8inx 2473 15 5 5 CD cord-010092-uftc8inx 2473 16 T T NNS cord-010092-uftc8inx 2473 17 are be VBP cord-010092-uftc8inx 2473 18 separate separate JJ cord-010092-uftc8inx 2473 19 and and CC cord-010092-uftc8inx 2473 20 that that IN cord-010092-uftc8inx 2473 21 GYPB*s gypb*s NN cord-010092-uftc8inx 2473 22 was be VBD cord-010092-uftc8inx 2473 23 also also RB cord-010092-uftc8inx 2473 24 silenced silence VBN cord-010092-uftc8inx 2473 25 . . . cord-010092-uftc8inx 2474 1 Robust Robust NNP cord-010092-uftc8inx 2474 2 s+ s+ NNP cord-010092-uftc8inx 2474 3 RBC RBC NNP cord-010092-uftc8inx 2474 4 typing typing NN cord-010092-uftc8inx 2474 5 indicates indicate VBZ cord-010092-uftc8inx 2474 6 both both DT cord-010092-uftc8inx 2474 7 changes change NNS cord-010092-uftc8inx 2474 8 are be VBP cord-010092-uftc8inx 2474 9 on on IN cord-010092-uftc8inx 2474 10 GYPB*S. GYPB*S. NNP cord-010092-uftc8inx 2474 11 Gene Gene NNP cord-010092-uftc8inx 2474 12 sequencing sequencing NN cord-010092-uftc8inx 2474 13 confirms confirm VBZ cord-010092-uftc8inx 2474 14 the the DT cord-010092-uftc8inx 2474 15 c.270 c.270 NNP cord-010092-uftc8inx 2474 16 + + SYM cord-010092-uftc8inx 2474 17 5 5 CD cord-010092-uftc8inx 2474 18 T t NN cord-010092-uftc8inx 2474 19 change change NN cord-010092-uftc8inx 2474 20 is be VBZ cord-010092-uftc8inx 2474 21 on on IN cord-010092-uftc8inx 2474 22 a a DT cord-010092-uftc8inx 2474 23 GYPB*03N.02 gypb*03n.02 JJ cord-010092-uftc8inx 2474 24 [ [ -LRB- cord-010092-uftc8inx 2474 25 GYP*He(NY gyp*he(ny NN cord-010092-uftc8inx 2474 26 ) ) -RRB- cord-010092-uftc8inx 2474 27 ] ] -RRB- cord-010092-uftc8inx 2474 28 background background NN cord-010092-uftc8inx 2474 29 . . . cord-010092-uftc8inx 2475 1 c.230C c.230C NNP cord-010092-uftc8inx 2476 1 > > XX cord-010092-uftc8inx 2477 1 T T NNP cord-010092-uftc8inx 2477 2 ( ( -LRB- cord-010092-uftc8inx 2477 3 rs79492560 rs79492560 NNP cord-010092-uftc8inx 2477 4 ) ) -RRB- cord-010092-uftc8inx 2477 5 and and CC cord-010092-uftc8inx 2477 6 c.270 c.270 NNP cord-010092-uftc8inx 2477 7 + + SYM cord-010092-uftc8inx 2477 8 5 5 CD cord-010092-uftc8inx 2477 9 G g NN cord-010092-uftc8inx 2478 1 > > XX cord-010092-uftc8inx 2479 1 T T NNP cord-010092-uftc8inx 2479 2 ( ( -LRB- cord-010092-uftc8inx 2479 3 rs139511876 rs139511876 NNP cord-010092-uftc8inx 2479 4 ) ) -RRB- cord-010092-uftc8inx 2479 5 have have VB cord-010092-uftc8inx 2479 6 a a DT cord-010092-uftc8inx 2479 7 frequency frequency NN cord-010092-uftc8inx 2479 8 of of IN cord-010092-uftc8inx 2479 9 0.0053 0.0053 CD cord-010092-uftc8inx 2479 10 respectively respectively RB cord-010092-uftc8inx 2479 11 0.032 0.032 CD cord-010092-uftc8inx 2479 12 in in IN cord-010092-uftc8inx 2479 13 the the DT cord-010092-uftc8inx 2479 14 African african JJ cord-010092-uftc8inx 2479 15 population population NN cord-010092-uftc8inx 2479 16 ( ( -LRB- cord-010092-uftc8inx 2479 17 ExAC ExAC NNP cord-010092-uftc8inx 2479 18 ) ) -RRB- cord-010092-uftc8inx 2479 19 . . . cord-010092-uftc8inx 2480 1 Although although IN cord-010092-uftc8inx 2480 2 we -PRON- PRP cord-010092-uftc8inx 2480 3 identified identify VBD cord-010092-uftc8inx 2480 4 3 3 CD cord-010092-uftc8inx 2480 5 samples sample NNS cord-010092-uftc8inx 2480 6 , , , cord-010092-uftc8inx 2480 7 the the DT cord-010092-uftc8inx 2480 8 frequency frequency NN cord-010092-uftc8inx 2480 9 of of IN cord-010092-uftc8inx 2480 10 this this DT cord-010092-uftc8inx 2480 11 novel novel JJ cord-010092-uftc8inx 2480 12 allele allele NN cord-010092-uftc8inx 2480 13 is be VBZ cord-010092-uftc8inx 2480 14 unknown unknown JJ cord-010092-uftc8inx 2480 15 . . . cord-010092-uftc8inx 2481 1 Background background NN cord-010092-uftc8inx 2481 2 : : : cord-010092-uftc8inx 2482 1 The the DT cord-010092-uftc8inx 2482 2 Lutheran Lutheran NNP cord-010092-uftc8inx 2482 3 blood blood NN cord-010092-uftc8inx 2482 4 group group NN cord-010092-uftc8inx 2482 5 system system NN cord-010092-uftc8inx 2482 6 currently currently RB cord-010092-uftc8inx 2482 7 consists consist VBZ cord-010092-uftc8inx 2482 8 of of IN cord-010092-uftc8inx 2482 9 25 25 CD cord-010092-uftc8inx 2482 10 antigens antigen NNS cord-010092-uftc8inx 2482 11 . . . cord-010092-uftc8inx 2483 1 These these DT cord-010092-uftc8inx 2483 2 antigens antigen NNS cord-010092-uftc8inx 2483 3 are be VBP cord-010092-uftc8inx 2483 4 of of IN cord-010092-uftc8inx 2483 5 low low JJ cord-010092-uftc8inx 2483 6 immunogenicity immunogenicity NN cord-010092-uftc8inx 2483 7 and and CC cord-010092-uftc8inx 2483 8 may may MD cord-010092-uftc8inx 2483 9 cause cause VB cord-010092-uftc8inx 2483 10 mild mild JJ cord-010092-uftc8inx 2483 11 - - HYPH cord-010092-uftc8inx 2483 12 to to IN cord-010092-uftc8inx 2483 13 - - HYPH cord-010092-uftc8inx 2483 14 moderate moderate JJ cord-010092-uftc8inx 2483 15 transfusion transfusion NN cord-010092-uftc8inx 2483 16 reactions reaction NNS cord-010092-uftc8inx 2483 17 and and CC cord-010092-uftc8inx 2483 18 hemolytic hemolytic JJ cord-010092-uftc8inx 2483 19 disease disease NN cord-010092-uftc8inx 2483 20 of of IN cord-010092-uftc8inx 2483 21 the the DT cord-010092-uftc8inx 2483 22 fetus fetus NN cord-010092-uftc8inx 2483 23 and and CC cord-010092-uftc8inx 2483 24 newborn newborn JJ cord-010092-uftc8inx 2483 25 . . . cord-010092-uftc8inx 2484 1 The the DT cord-010092-uftc8inx 2484 2 activation activation NN cord-010092-uftc8inx 2484 3 of of IN cord-010092-uftc8inx 2484 4 Lu Lu NNP cord-010092-uftc8inx 2484 5 - - HYPH cord-010092-uftc8inx 2484 6 glycoprotein glycoprotein NNP cord-010092-uftc8inx 2484 7 / / SYM cord-010092-uftc8inx 2484 8 BCAM BCAM NNP cord-010092-uftc8inx 2484 9 on on IN cord-010092-uftc8inx 2484 10 red red JJ cord-010092-uftc8inx 2484 11 blood blood NN cord-010092-uftc8inx 2484 12 cells cell NNS cord-010092-uftc8inx 2484 13 ( ( -LRB- cord-010092-uftc8inx 2484 14 RBCs rbc NNS cord-010092-uftc8inx 2484 15 ) ) -RRB- cord-010092-uftc8inx 2484 16 and and CC cord-010092-uftc8inx 2484 17 its -PRON- PRP$ cord-010092-uftc8inx 2484 18 interaction interaction NN cord-010092-uftc8inx 2484 19 with with IN cord-010092-uftc8inx 2484 20 laminin-5a laminin-5a NNP cord-010092-uftc8inx 2484 21 is be VBZ cord-010092-uftc8inx 2484 22 thought think VBN cord-010092-uftc8inx 2484 23 to to TO cord-010092-uftc8inx 2484 24 play play VB cord-010092-uftc8inx 2484 25 a a DT cord-010092-uftc8inx 2484 26 role role NN cord-010092-uftc8inx 2484 27 in in IN cord-010092-uftc8inx 2484 28 vaso vaso NNP cord-010092-uftc8inx 2484 29 - - HYPH cord-010092-uftc8inx 2484 30 occlusion occlusion NN cord-010092-uftc8inx 2484 31 in in IN cord-010092-uftc8inx 2484 32 sickle sickle NN cord-010092-uftc8inx 2484 33 cell cell NN cord-010092-uftc8inx 2484 34 disease disease NN cord-010092-uftc8inx 2484 35 and and CC cord-010092-uftc8inx 2484 36 other other JJ cord-010092-uftc8inx 2484 37 hematological hematological JJ cord-010092-uftc8inx 2484 38 disorders disorder NNS cord-010092-uftc8inx 2484 39 . . . cord-010092-uftc8inx 2485 1 The the DT cord-010092-uftc8inx 2485 2 two two CD cord-010092-uftc8inx 2485 3 glycoprotein glycoprotein NN cord-010092-uftc8inx 2485 4 isoforms isoform NNS cord-010092-uftc8inx 2485 5 Lu Lu NNP cord-010092-uftc8inx 2485 6 - - HYPH cord-010092-uftc8inx 2485 7 glycoprotein glycoprotein NN cord-010092-uftc8inx 2485 8 and and CC cord-010092-uftc8inx 2485 9 BCAM BCAM NNP cord-010092-uftc8inx 2485 10 are be VBP cord-010092-uftc8inx 2485 11 encoded encode VBN cord-010092-uftc8inx 2485 12 by by IN cord-010092-uftc8inx 2485 13 the the DT cord-010092-uftc8inx 2485 14 BCAM BCAM NNP cord-010092-uftc8inx 2485 15 gene gene NN cord-010092-uftc8inx 2485 16 which which WDT cord-010092-uftc8inx 2485 17 consists consist VBZ cord-010092-uftc8inx 2485 18 of of IN cord-010092-uftc8inx 2485 19 15 15 CD cord-010092-uftc8inx 2485 20 exons exon NNS cord-010092-uftc8inx 2485 21 located locate VBN cord-010092-uftc8inx 2485 22 on on IN cord-010092-uftc8inx 2485 23 chromosome chromosome NN cord-010092-uftc8inx 2485 24 19q13.2 19q13.2 CD cord-010092-uftc8inx 2485 25 . . . cord-010092-uftc8inx 2486 1 A a DT cord-010092-uftc8inx 2486 2 number number NN cord-010092-uftc8inx 2486 3 of of IN cord-010092-uftc8inx 2486 4 rare rare JJ cord-010092-uftc8inx 2486 5 Lutheran Lutheran NNP cord-010092-uftc8inx 2486 6 phenotypes phenotype NNS cord-010092-uftc8inx 2486 7 have have VBP cord-010092-uftc8inx 2486 8 been be VBN cord-010092-uftc8inx 2486 9 previously previously RB cord-010092-uftc8inx 2486 10 recorded record VBN cord-010092-uftc8inx 2486 11 in in IN cord-010092-uftc8inx 2486 12 Israel Israel NNP cord-010092-uftc8inx 2486 13 , , , cord-010092-uftc8inx 2486 14 including include VBG cord-010092-uftc8inx 2486 15 LU:-6,9 LU:-6,9 NNP cord-010092-uftc8inx 2486 16 observed observe VBD cord-010092-uftc8inx 2486 17 among among IN cord-010092-uftc8inx 2486 18 Iranian iranian JJ cord-010092-uftc8inx 2486 19 Jews Jews NNPS cord-010092-uftc8inx 2486 20 , , , cord-010092-uftc8inx 2486 21 LU:-20 lu:-20 RB cord-010092-uftc8inx 2486 22 in in IN cord-010092-uftc8inx 2486 23 one one CD cord-010092-uftc8inx 2486 24 thalassemia thalassemia NN cord-010092-uftc8inx 2486 25 patient patient NN cord-010092-uftc8inx 2486 26 and and CC cord-010092-uftc8inx 2486 27 one one CD cord-010092-uftc8inx 2486 28 case case NN cord-010092-uftc8inx 2486 29 of of IN cord-010092-uftc8inx 2486 30 LU:-21 LU:-21 NNP cord-010092-uftc8inx 2486 31 . . . cord-010092-uftc8inx 2487 1 In in IN cord-010092-uftc8inx 2487 2 this this DT cord-010092-uftc8inx 2487 3 report report NN cord-010092-uftc8inx 2487 4 , , , cord-010092-uftc8inx 2487 5 a a DT cord-010092-uftc8inx 2487 6 previously previously RB cord-010092-uftc8inx 2487 7 transfused transfuse VBN cord-010092-uftc8inx 2487 8 pregnant pregnant JJ cord-010092-uftc8inx 2487 9 Arab arab JJ cord-010092-uftc8inx 2487 10 patient patient NN cord-010092-uftc8inx 2487 11 with with IN cord-010092-uftc8inx 2487 12 b b NN cord-010092-uftc8inx 2487 13 - - HYPH cord-010092-uftc8inx 2487 14 thalassemia thalassemia NN cord-010092-uftc8inx 2487 15 intermedia intermedia NN cord-010092-uftc8inx 2487 16 was be VBD cord-010092-uftc8inx 2487 17 investigated investigate VBN cord-010092-uftc8inx 2487 18 because because IN cord-010092-uftc8inx 2487 19 she -PRON- PRP cord-010092-uftc8inx 2487 20 presented present VBD cord-010092-uftc8inx 2487 21 with with IN cord-010092-uftc8inx 2487 22 an an DT cord-010092-uftc8inx 2487 23 antibody antibody NN cord-010092-uftc8inx 2487 24 to to IN cord-010092-uftc8inx 2487 25 an an DT cord-010092-uftc8inx 2487 26 unknown unknown JJ cord-010092-uftc8inx 2487 27 high high JJ cord-010092-uftc8inx 2487 28 frequency frequency NN cord-010092-uftc8inx 2487 29 antigen antigen NN cord-010092-uftc8inx 2487 30 ( ( -LRB- cord-010092-uftc8inx 2487 31 HFA HFA NNP cord-010092-uftc8inx 2487 32 ) ) -RRB- cord-010092-uftc8inx 2487 33 , , , cord-010092-uftc8inx 2487 34 potentially potentially RB cord-010092-uftc8inx 2487 35 related related JJ cord-010092-uftc8inx 2487 36 to to IN cord-010092-uftc8inx 2487 37 the the DT cord-010092-uftc8inx 2487 38 Lutheran Lutheran NNP cord-010092-uftc8inx 2487 39 system system NN cord-010092-uftc8inx 2487 40 . . . cord-010092-uftc8inx 2488 1 Aims aim VBZ cord-010092-uftc8inx 2488 2 : : : cord-010092-uftc8inx 2488 3 To to TO cord-010092-uftc8inx 2488 4 characterize characterize VB cord-010092-uftc8inx 2488 5 a a DT cord-010092-uftc8inx 2488 6 novel novel JJ cord-010092-uftc8inx 2488 7 Lutheran Lutheran NNP cord-010092-uftc8inx 2488 8 antigen antigen NN cord-010092-uftc8inx 2488 9 through through IN cord-010092-uftc8inx 2488 10 serological serological JJ cord-010092-uftc8inx 2488 11 and and CC cord-010092-uftc8inx 2488 12 molecular molecular JJ cord-010092-uftc8inx 2488 13 investigation investigation NN cord-010092-uftc8inx 2488 14 of of IN cord-010092-uftc8inx 2488 15 a a DT cord-010092-uftc8inx 2488 16 patient patient NN cord-010092-uftc8inx 2488 17 with with IN cord-010092-uftc8inx 2488 18 a a DT cord-010092-uftc8inx 2488 19 Lutheran Lutheran NNP cord-010092-uftc8inx 2488 20 related related JJ cord-010092-uftc8inx 2488 21 antibody antibody NN cord-010092-uftc8inx 2488 22 . . . cord-010092-uftc8inx 2489 1 Methods method NNS cord-010092-uftc8inx 2489 2 : : : cord-010092-uftc8inx 2489 3 Initially initially RB cord-010092-uftc8inx 2489 4 , , , cord-010092-uftc8inx 2489 5 the the DT cord-010092-uftc8inx 2489 6 red red JJ cord-010092-uftc8inx 2489 7 cell cell NN cord-010092-uftc8inx 2489 8 phenotype phenotype NN cord-010092-uftc8inx 2489 9 and and CC cord-010092-uftc8inx 2489 10 the the DT cord-010092-uftc8inx 2489 11 presence presence NN cord-010092-uftc8inx 2489 12 of of IN cord-010092-uftc8inx 2489 13 a a DT cord-010092-uftc8inx 2489 14 Lutheran Lutheran NNP cord-010092-uftc8inx 2489 15 related related JJ cord-010092-uftc8inx 2489 16 antibody antibody NN cord-010092-uftc8inx 2489 17 in in IN cord-010092-uftc8inx 2489 18 the the DT cord-010092-uftc8inx 2489 19 serum serum NN cord-010092-uftc8inx 2489 20 of of IN cord-010092-uftc8inx 2489 21 the the DT cord-010092-uftc8inx 2489 22 patient patient NN cord-010092-uftc8inx 2489 23 were be VBD cord-010092-uftc8inx 2489 24 detected detect VBN cord-010092-uftc8inx 2489 25 by by IN cord-010092-uftc8inx 2489 26 standard standard JJ cord-010092-uftc8inx 2489 27 serological serological JJ cord-010092-uftc8inx 2489 28 techniques technique NNS cord-010092-uftc8inx 2489 29 , , , cord-010092-uftc8inx 2489 30 utilizing utilize VBG cord-010092-uftc8inx 2489 31 enzyme enzyme NN cord-010092-uftc8inx 2489 32 treated treat VBN cord-010092-uftc8inx 2489 33 and and CC cord-010092-uftc8inx 2489 34 chemically chemically RB cord-010092-uftc8inx 2489 35 modified modify VBN cord-010092-uftc8inx 2489 36 cells cell NNS cord-010092-uftc8inx 2489 37 and and CC cord-010092-uftc8inx 2489 38 rare rare JJ cord-010092-uftc8inx 2489 39 cells cell NNS cord-010092-uftc8inx 2489 40 and and CC cord-010092-uftc8inx 2489 41 sera sera NNP cord-010092-uftc8inx 2489 42 from from IN cord-010092-uftc8inx 2489 43 the the DT cord-010092-uftc8inx 2489 44 NBGRL NBGRL NNP cord-010092-uftc8inx 2489 45 collection collection NN cord-010092-uftc8inx 2489 46 . . . cord-010092-uftc8inx 2490 1 Further further JJ cord-010092-uftc8inx 2490 2 serological serological JJ cord-010092-uftc8inx 2490 3 investigations investigation NNS cord-010092-uftc8inx 2490 4 were be VBD cord-010092-uftc8inx 2490 5 carried carry VBN cord-010092-uftc8inx 2490 6 out out RP cord-010092-uftc8inx 2490 7 using use VBG cord-010092-uftc8inx 2490 8 standard standard JJ cord-010092-uftc8inx 2490 9 IAT IAT NNP cord-010092-uftc8inx 2490 10 ( ( -LRB- cord-010092-uftc8inx 2490 11 LISS LISS NNP cord-010092-uftc8inx 2490 12 tube tube NN cord-010092-uftc8inx 2490 13 and and CC cord-010092-uftc8inx 2490 14 Bio Bio NNP cord-010092-uftc8inx 2490 15 - - HYPH cord-010092-uftc8inx 2490 16 Rad Rad NNP cord-010092-uftc8inx 2490 17 gel gel NN cord-010092-uftc8inx 2490 18 ) ) -RRB- cord-010092-uftc8inx 2490 19 technique technique NN cord-010092-uftc8inx 2490 20 . . . cord-010092-uftc8inx 2491 1 Plasma plasma NN cord-010092-uftc8inx 2491 2 inhibition inhibition NN cord-010092-uftc8inx 2491 3 studies study NNS cord-010092-uftc8inx 2491 4 were be VBD cord-010092-uftc8inx 2491 5 performed perform VBN cord-010092-uftc8inx 2491 6 using use VBG cord-010092-uftc8inx 2491 7 soluble soluble JJ cord-010092-uftc8inx 2491 8 recombinant recombinant JJ cord-010092-uftc8inx 2491 9 Lu Lu NNP cord-010092-uftc8inx 2491 10 protein protein NN cord-010092-uftc8inx 2491 11 ( ( -LRB- cord-010092-uftc8inx 2491 12 srLu srLu NNP cord-010092-uftc8inx 2491 13 ) ) -RRB- cord-010092-uftc8inx 2491 14 . . . cord-010092-uftc8inx 2492 1 Eluates Eluates NNPS cord-010092-uftc8inx 2492 2 were be VBD cord-010092-uftc8inx 2492 3 prepared prepare VBN cord-010092-uftc8inx 2492 4 using use VBG cord-010092-uftc8inx 2492 5 acid acid NN cord-010092-uftc8inx 2492 6 elution elution NN cord-010092-uftc8inx 2492 7 method method NN cord-010092-uftc8inx 2492 8 ( ( -LRB- cord-010092-uftc8inx 2492 9 Gamma Gamma NNP cord-010092-uftc8inx 2492 10 Elu Elu NNP cord-010092-uftc8inx 2492 11 - - HYPH cord-010092-uftc8inx 2492 12 kit kit NN cord-010092-uftc8inx 2492 13 II II NNP cord-010092-uftc8inx 2492 14 ) ) -RRB- cord-010092-uftc8inx 2492 15 . . . cord-010092-uftc8inx 2493 1 Genomic genomic JJ cord-010092-uftc8inx 2493 2 DNA dna NN cord-010092-uftc8inx 2493 3 was be VBD cord-010092-uftc8inx 2493 4 isolated isolate VBN cord-010092-uftc8inx 2493 5 from from IN cord-010092-uftc8inx 2493 6 whole whole JJ cord-010092-uftc8inx 2493 7 blood blood NN cord-010092-uftc8inx 2493 8 and and CC cord-010092-uftc8inx 2493 9 all all DT cord-010092-uftc8inx 2493 10 exons exon NNS cord-010092-uftc8inx 2493 11 of of IN cord-010092-uftc8inx 2493 12 the the DT cord-010092-uftc8inx 2493 13 BCAM BCAM NNP cord-010092-uftc8inx 2493 14 gene gene NN cord-010092-uftc8inx 2493 15 were be VBD cord-010092-uftc8inx 2493 16 amplified amplify VBN cord-010092-uftc8inx 2493 17 by by IN cord-010092-uftc8inx 2493 18 PCR PCR NNP cord-010092-uftc8inx 2493 19 and and CC cord-010092-uftc8inx 2493 20 directly directly RB cord-010092-uftc8inx 2493 21 sequenced sequence VBN cord-010092-uftc8inx 2493 22 by by IN cord-010092-uftc8inx 2493 23 Sanger Sanger NNP cord-010092-uftc8inx 2493 24 sequencing sequencing NN cord-010092-uftc8inx 2493 25 . . . cord-010092-uftc8inx 2494 1 The the DT cord-010092-uftc8inx 2494 2 impact impact NN cord-010092-uftc8inx 2494 3 of of IN cord-010092-uftc8inx 2494 4 the the DT cord-010092-uftc8inx 2494 5 identified identify VBN cord-010092-uftc8inx 2494 6 mutation mutation NN cord-010092-uftc8inx 2494 7 on on IN cord-010092-uftc8inx 2494 8 Lutheran Lutheran NNP cord-010092-uftc8inx 2494 9 glycoprotein glycoprotein NN cord-010092-uftc8inx 2494 10 structure structure NN cord-010092-uftc8inx 2494 11 was be VBD cord-010092-uftc8inx 2494 12 studied study VBN cord-010092-uftc8inx 2494 13 by by IN cord-010092-uftc8inx 2494 14 molecular molecular JJ cord-010092-uftc8inx 2494 15 dynamics dynamic NNS cord-010092-uftc8inx 2494 16 calculations calculation NNS cord-010092-uftc8inx 2494 17 . . . cord-010092-uftc8inx 2495 1 Results result NNS cord-010092-uftc8inx 2495 2 : : : cord-010092-uftc8inx 2496 1 The the DT cord-010092-uftc8inx 2496 2 patient patient NN cord-010092-uftc8inx 2496 3 's 's POS cord-010092-uftc8inx 2496 4 plasma plasma NN cord-010092-uftc8inx 2496 5 reacted react VBD cord-010092-uftc8inx 2496 6 with with IN cord-010092-uftc8inx 2496 7 all all DT cord-010092-uftc8inx 2496 8 cells cell NNS cord-010092-uftc8inx 2496 9 tested test VBN cord-010092-uftc8inx 2496 10 , , , cord-010092-uftc8inx 2496 11 except except IN cord-010092-uftc8inx 2496 12 for for IN cord-010092-uftc8inx 2496 13 three three CD cord-010092-uftc8inx 2496 14 examples example NNS cord-010092-uftc8inx 2496 15 of of IN cord-010092-uftc8inx 2496 16 In(Lu in(lu CD cord-010092-uftc8inx 2496 17 ) ) -RRB- cord-010092-uftc8inx 2496 18 cells cell NNS cord-010092-uftc8inx 2496 19 and and CC cord-010092-uftc8inx 2496 20 cells cell NNS cord-010092-uftc8inx 2496 21 treated treat VBN cord-010092-uftc8inx 2496 22 with with IN cord-010092-uftc8inx 2496 23 2-aminoethylisothiouronium 2-aminoethylisothiouronium CD cord-010092-uftc8inx 2496 24 bromide bromide NN cord-010092-uftc8inx 2496 25 , , , cord-010092-uftc8inx 2496 26 trypsin trypsin NN cord-010092-uftc8inx 2496 27 and and CC cord-010092-uftc8inx 2496 28 a a DT cord-010092-uftc8inx 2496 29 - - HYPH cord-010092-uftc8inx 2496 30 chymotrypsin chymotrypsin NN cord-010092-uftc8inx 2496 31 . . . cord-010092-uftc8inx 2497 1 Inhibition inhibition NN cord-010092-uftc8inx 2497 2 studies study NNS cord-010092-uftc8inx 2497 3 with with IN cord-010092-uftc8inx 2497 4 srLu srLu NNP cord-010092-uftc8inx 2497 5 protein protein NN cord-010092-uftc8inx 2497 6 showed show VBD cord-010092-uftc8inx 2497 7 complete complete JJ cord-010092-uftc8inx 2497 8 inhibition inhibition NN cord-010092-uftc8inx 2497 9 of of IN cord-010092-uftc8inx 2497 10 the the DT cord-010092-uftc8inx 2497 11 antibody antibody NN cord-010092-uftc8inx 2497 12 , , , cord-010092-uftc8inx 2497 13 thereby thereby RB cord-010092-uftc8inx 2497 14 confirming confirm VBG cord-010092-uftc8inx 2497 15 the the DT cord-010092-uftc8inx 2497 16 antibody antibody NN cord-010092-uftc8inx 2497 17 to to TO cord-010092-uftc8inx 2497 18 be be VB cord-010092-uftc8inx 2497 19 directed direct VBN cord-010092-uftc8inx 2497 20 toward toward IN cord-010092-uftc8inx 2497 21 an an DT cord-010092-uftc8inx 2497 22 epitope epitope NN cord-010092-uftc8inx 2497 23 on on IN cord-010092-uftc8inx 2497 24 the the DT cord-010092-uftc8inx 2497 25 Lu Lu NNP cord-010092-uftc8inx 2497 26 - - HYPH cord-010092-uftc8inx 2497 27 glycoprotein glycoprotein NN cord-010092-uftc8inx 2497 28 . . . cord-010092-uftc8inx 2498 1 In in IN cord-010092-uftc8inx 2498 2 addition addition NN cord-010092-uftc8inx 2498 3 , , , cord-010092-uftc8inx 2498 4 testing testing NN cord-010092-uftc8inx 2498 5 of of IN cord-010092-uftc8inx 2498 6 inhibited inhibited JJ cord-010092-uftc8inx 2498 7 plasma plasma NN cord-010092-uftc8inx 2498 8 revealed reveal VBD cord-010092-uftc8inx 2498 9 the the DT cord-010092-uftc8inx 2498 10 presence presence NN cord-010092-uftc8inx 2498 11 of of IN cord-010092-uftc8inx 2498 12 underlying underlie VBG cord-010092-uftc8inx 2498 13 anti anti JJ cord-010092-uftc8inx 2498 14 - - JJ cord-010092-uftc8inx 2498 15 E e JJ cord-010092-uftc8inx 2498 16 and and CC cord-010092-uftc8inx 2498 17 anti anti JJ cord-010092-uftc8inx 2498 18 - - JJ cord-010092-uftc8inx 2498 19 Fy Fy NNP cord-010092-uftc8inx 2498 20 a a NN cord-010092-uftc8inx 2498 21 . . . cord-010092-uftc8inx 2499 1 An an DT cord-010092-uftc8inx 2499 2 eluate eluate NN cord-010092-uftc8inx 2499 3 was be VBD cord-010092-uftc8inx 2499 4 prepared prepared JJ cord-010092-uftc8inx 2499 5 to to TO cord-010092-uftc8inx 2499 6 isolate isolate VB cord-010092-uftc8inx 2499 7 the the DT cord-010092-uftc8inx 2499 8 patient patient NN cord-010092-uftc8inx 2499 9 's 's POS cord-010092-uftc8inx 2499 10 Lu Lu NNP cord-010092-uftc8inx 2499 11 - - HYPH cord-010092-uftc8inx 2499 12 related relate VBN cord-010092-uftc8inx 2499 13 antibody antibody NN cord-010092-uftc8inx 2499 14 and and CC cord-010092-uftc8inx 2499 15 this this DT cord-010092-uftc8inx 2499 16 eluate eluate NN cord-010092-uftc8inx 2499 17 was be VBD cord-010092-uftc8inx 2499 18 found find VBN cord-010092-uftc8inx 2499 19 to to TO cord-010092-uftc8inx 2499 20 be be VB cord-010092-uftc8inx 2499 21 incompatible incompatible JJ cord-010092-uftc8inx 2499 22 with with IN cord-010092-uftc8inx 2499 23 examples example NNS cord-010092-uftc8inx 2499 24 of of IN cord-010092-uftc8inx 2499 25 LU:-5 LU:-5 NNP cord-010092-uftc8inx 2499 26 , , , cord-010092-uftc8inx 2499 27 LU:-6 LU:-6 NNP cord-010092-uftc8inx 2499 28 , , , cord-010092-uftc8inx 2499 29 LU:-8 lu:-8 CD cord-010092-uftc8inx 2499 30 , , , cord-010092-uftc8inx 2499 31 LU:-13 LU:-13 NNP cord-010092-uftc8inx 2499 32 , , , cord-010092-uftc8inx 2499 33 LU:-21 LU:-21 NNP cord-010092-uftc8inx 2499 34 , , , cord-010092-uftc8inx 2499 35 LU:-22 lu:-22 NN cord-010092-uftc8inx 2499 36 , , , cord-010092-uftc8inx 2499 37 and and CC cord-010092-uftc8inx 2499 38 LU:-23 lu:-23 NN cord-010092-uftc8inx 2499 39 cells cell NNS cord-010092-uftc8inx 2499 40 , , , cord-010092-uftc8inx 2499 41 whereas whereas IN cord-010092-uftc8inx 2499 42 In(Lu In(Lu NNP cord-010092-uftc8inx 2499 43 ) ) -RRB- cord-010092-uftc8inx 2499 44 were be VBD cord-010092-uftc8inx 2499 45 compatible compatible JJ cord-010092-uftc8inx 2499 46 . . . cord-010092-uftc8inx 2500 1 Results result NNS cord-010092-uftc8inx 2500 2 of of IN cord-010092-uftc8inx 2500 3 serological serological JJ cord-010092-uftc8inx 2500 4 typing typing NN cord-010092-uftc8inx 2500 5 of of IN cord-010092-uftc8inx 2500 6 the the DT cord-010092-uftc8inx 2500 7 patient patient NN cord-010092-uftc8inx 2500 8 's 's POS cord-010092-uftc8inx 2500 9 cells cell NNS cord-010092-uftc8inx 2500 10 , , , cord-010092-uftc8inx 2500 11 for for IN cord-010092-uftc8inx 2500 12 Lu Lu NNP cord-010092-uftc8inx 2500 13 system system NN cord-010092-uftc8inx 2500 14 HFAs hfas NN cord-010092-uftc8inx 2500 15 , , , cord-010092-uftc8inx 2500 16 could could MD cord-010092-uftc8inx 2500 17 not not RB cord-010092-uftc8inx 2500 18 be be VB cord-010092-uftc8inx 2500 19 conclusively conclusively RB cord-010092-uftc8inx 2500 20 determined determine VBN cord-010092-uftc8inx 2500 21 due due IN cord-010092-uftc8inx 2500 22 to to IN cord-010092-uftc8inx 2500 23 the the DT cord-010092-uftc8inx 2500 24 patient patient NN cord-010092-uftc8inx 2500 25 having have VBG cord-010092-uftc8inx 2500 26 been be VBN cord-010092-uftc8inx 2500 27 recently recently RB cord-010092-uftc8inx 2500 28 transfused transfuse VBN cord-010092-uftc8inx 2500 29 . . . cord-010092-uftc8inx 2501 1 However however RB cord-010092-uftc8inx 2501 2 , , , cord-010092-uftc8inx 2501 3 results result NNS cord-010092-uftc8inx 2501 4 suggested suggest VBD cord-010092-uftc8inx 2501 5 ( ( -LRB- cord-010092-uftc8inx 2501 6 through through IN cord-010092-uftc8inx 2501 7 absence absence NN cord-010092-uftc8inx 2501 8 of of IN cord-010092-uftc8inx 2501 9 mixed mixed JJ cord-010092-uftc8inx 2501 10 field field NN cord-010092-uftc8inx 2501 11 reactivity reactivity NN cord-010092-uftc8inx 2501 12 ) ) -RRB- cord-010092-uftc8inx 2501 13 the the DT cord-010092-uftc8inx 2501 14 patient patient NN cord-010092-uftc8inx 2501 15 's 's POS cord-010092-uftc8inx 2501 16 cells cell NNS cord-010092-uftc8inx 2501 17 to to TO cord-010092-uftc8inx 2501 18 be be VB cord-010092-uftc8inx 2501 19 LU LU NNP cord-010092-uftc8inx 2501 20 : : : cord-010092-uftc8inx 2502 1 -1,2,8,12,13,-19,21 -1,2,8,12,13,-19,21 ADD cord-010092-uftc8inx 2502 2 . . . cord-010092-uftc8inx 2503 1 BCAM BCAM NNP cord-010092-uftc8inx 2503 2 sequence sequence NN cord-010092-uftc8inx 2503 3 analysis analysis NN cord-010092-uftc8inx 2503 4 confirmed confirm VBD cord-010092-uftc8inx 2503 5 the the DT cord-010092-uftc8inx 2503 6 patient patient NN cord-010092-uftc8inx 2503 7 to to TO cord-010092-uftc8inx 2503 8 be be VB cord-010092-uftc8inx 2503 9 LU*02 LU*02 NNS cord-010092-uftc8inx 2503 10 , , , cord-010092-uftc8inx 2503 11 LU*18 LU*18 NNP cord-010092-uftc8inx 2503 12 and and CC cord-010092-uftc8inx 2503 13 revealed reveal VBD cord-010092-uftc8inx 2503 14 a a DT cord-010092-uftc8inx 2503 15 novel novel JJ cord-010092-uftc8inx 2503 16 homozygous homozygous JJ cord-010092-uftc8inx 2503 17 mutation mutation NN cord-010092-uftc8inx 2503 18 c.1351A c.1351a NN cord-010092-uftc8inx 2503 19 > > XX cord-010092-uftc8inx 2503 20 C c NN cord-010092-uftc8inx 2503 21 in in IN cord-010092-uftc8inx 2503 22 exon exon NN cord-010092-uftc8inx 2503 23 11 11 CD cord-010092-uftc8inx 2503 24 , , , cord-010092-uftc8inx 2503 25 encoding encode VBG cord-010092-uftc8inx 2503 26 p. p. NN cord-010092-uftc8inx 2504 1 Lys451Gln lys451gln XX cord-010092-uftc8inx 2504 2 in in IN cord-010092-uftc8inx 2504 3 the the DT cord-010092-uftc8inx 2504 4 Lutheran Lutheran NNP cord-010092-uftc8inx 2504 5 glycoprotein glycoprotein NN cord-010092-uftc8inx 2504 6 . . . cord-010092-uftc8inx 2505 1 Summary Summary NNP cord-010092-uftc8inx 2505 2 / / SYM cord-010092-uftc8inx 2505 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 2505 4 : : : cord-010092-uftc8inx 2506 1 A a DT cord-010092-uftc8inx 2506 2 novel novel JJ cord-010092-uftc8inx 2506 3 homozygous homozygous JJ cord-010092-uftc8inx 2506 4 mutation mutation NN cord-010092-uftc8inx 2507 1 c.1351A c.1351A NNP cord-010092-uftc8inx 2507 2 > > XX cord-010092-uftc8inx 2508 1 C C NNP cord-010092-uftc8inx 2508 2 ( ( -LRB- cord-010092-uftc8inx 2508 3 p. p. NN cord-010092-uftc8inx 2509 1 Lys451Gln lys451gln LS cord-010092-uftc8inx 2509 2 ) ) -RRB- cord-010092-uftc8inx 2510 1 in in IN cord-010092-uftc8inx 2510 2 exon exon NN cord-010092-uftc8inx 2510 3 11 11 CD cord-010092-uftc8inx 2510 4 of of IN cord-010092-uftc8inx 2510 5 BCAM BCAM NNP cord-010092-uftc8inx 2510 6 was be VBD cord-010092-uftc8inx 2510 7 identified identify VBN cord-010092-uftc8inx 2510 8 in in IN cord-010092-uftc8inx 2510 9 a a DT cord-010092-uftc8inx 2510 10 patient patient NN cord-010092-uftc8inx 2510 11 with with IN cord-010092-uftc8inx 2510 12 an an DT cord-010092-uftc8inx 2510 13 antibody antibody NN cord-010092-uftc8inx 2510 14 to to IN cord-010092-uftc8inx 2510 15 a a DT cord-010092-uftc8inx 2510 16 Lutheran Lutheran NNP cord-010092-uftc8inx 2510 17 HFA HFA NNP cord-010092-uftc8inx 2510 18 . . . cord-010092-uftc8inx 2511 1 Serological serological JJ cord-010092-uftc8inx 2511 2 and and CC cord-010092-uftc8inx 2511 3 genetic genetic JJ cord-010092-uftc8inx 2511 4 evidence evidence NN cord-010092-uftc8inx 2511 5 presented present VBN cord-010092-uftc8inx 2511 6 here here RB cord-010092-uftc8inx 2511 7 indicates indicate VBZ cord-010092-uftc8inx 2511 8 discovery discovery NN cord-010092-uftc8inx 2511 9 of of IN cord-010092-uftc8inx 2511 10 a a DT cord-010092-uftc8inx 2511 11 novel novel JJ cord-010092-uftc8inx 2511 12 antigen antigen NN cord-010092-uftc8inx 2511 13 of of IN cord-010092-uftc8inx 2511 14 the the DT cord-010092-uftc8inx 2511 15 Lutheran Lutheran NNP cord-010092-uftc8inx 2511 16 blood blood NN cord-010092-uftc8inx 2511 17 group group NN cord-010092-uftc8inx 2511 18 system system NN cord-010092-uftc8inx 2511 19 , , , cord-010092-uftc8inx 2511 20 which which WDT cord-010092-uftc8inx 2511 21 we -PRON- PRP cord-010092-uftc8inx 2511 22 propose propose VBP cord-010092-uftc8inx 2511 23 to to TO cord-010092-uftc8inx 2511 24 name name VB cord-010092-uftc8inx 2511 25 LURA LURA NNP cord-010092-uftc8inx 2511 26 . . . cord-010092-uftc8inx 2512 1 Background background NN cord-010092-uftc8inx 2512 2 : : : cord-010092-uftc8inx 2512 3 Lutheran Lutheran NNP cord-010092-uftc8inx 2512 4 glycoprotein glycoprotein NN cord-010092-uftc8inx 2512 5 and and CC cord-010092-uftc8inx 2512 6 basal basal NN cord-010092-uftc8inx 2512 7 cell cell NN cord-010092-uftc8inx 2512 8 adhesion adhesion NN cord-010092-uftc8inx 2512 9 molecule molecule NN cord-010092-uftc8inx 2512 10 antigen antigen NN cord-010092-uftc8inx 2512 11 B B NNP cord-010092-uftc8inx 2512 12 - - HYPH cord-010092-uftc8inx 2512 13 CAM CAM NNP cord-010092-uftc8inx 2512 14 are be VBP cord-010092-uftc8inx 2512 15 two two CD cord-010092-uftc8inx 2512 16 isoforms isoform NNS cord-010092-uftc8inx 2512 17 of of IN cord-010092-uftc8inx 2512 18 a a DT cord-010092-uftc8inx 2512 19 type type NN cord-010092-uftc8inx 2512 20 I -PRON- PRP cord-010092-uftc8inx 2512 21 membrane membrane NN cord-010092-uftc8inx 2512 22 glycoprotein glycoprotein NN cord-010092-uftc8inx 2512 23 residing reside VBG cord-010092-uftc8inx 2512 24 on on IN cord-010092-uftc8inx 2512 25 red red JJ cord-010092-uftc8inx 2512 26 cell cell NN cord-010092-uftc8inx 2512 27 surfaces surface NNS cord-010092-uftc8inx 2512 28 . . . cord-010092-uftc8inx 2513 1 Both both DT cord-010092-uftc8inx 2513 2 isoforms isoform NNS cord-010092-uftc8inx 2513 3 are be VBP cord-010092-uftc8inx 2513 4 adhesion adhesion NN cord-010092-uftc8inx 2513 5 molecules molecule NNS cord-010092-uftc8inx 2513 6 with with IN cord-010092-uftc8inx 2513 7 the the DT cord-010092-uftc8inx 2513 8 main main JJ cord-010092-uftc8inx 2513 9 function function NN cord-010092-uftc8inx 2513 10 of of IN cord-010092-uftc8inx 2513 11 laminin laminin NN cord-010092-uftc8inx 2513 12 binding binding NN cord-010092-uftc8inx 2513 13 , , , cord-010092-uftc8inx 2513 14 and and CC cord-010092-uftc8inx 2513 15 both both DT cord-010092-uftc8inx 2513 16 carry carry VBP cord-010092-uftc8inx 2513 17 antigens antigen NNS cord-010092-uftc8inx 2513 18 of of IN cord-010092-uftc8inx 2513 19 the the DT cord-010092-uftc8inx 2513 20 Lutheran Lutheran NNP cord-010092-uftc8inx 2513 21 blood blood NN cord-010092-uftc8inx 2513 22 group group NN cord-010092-uftc8inx 2513 23 system system NN cord-010092-uftc8inx 2513 24 ( ( -LRB- cord-010092-uftc8inx 2513 25 LU LU NNP cord-010092-uftc8inx 2513 26 ) ) -RRB- cord-010092-uftc8inx 2513 27 . . . cord-010092-uftc8inx 2514 1 The the DT cord-010092-uftc8inx 2514 2 system system NN cord-010092-uftc8inx 2514 3 currently currently RB cord-010092-uftc8inx 2514 4 comprises comprise VBZ cord-010092-uftc8inx 2514 5 25 25 CD cord-010092-uftc8inx 2514 6 antigens antigen NNS cord-010092-uftc8inx 2514 7 , , , cord-010092-uftc8inx 2514 8 all all DT cord-010092-uftc8inx 2514 9 encoded encode VBN cord-010092-uftc8inx 2514 10 by by IN cord-010092-uftc8inx 2514 11 mutations mutation NNS cord-010092-uftc8inx 2514 12 in in IN cord-010092-uftc8inx 2514 13 the the DT cord-010092-uftc8inx 2514 14 alternatively alternatively RB cord-010092-uftc8inx 2514 15 spliced splice VBN cord-010092-uftc8inx 2514 16 single single JJ cord-010092-uftc8inx 2514 17 gene gene NN cord-010092-uftc8inx 2514 18 BCAM BCAM NNP cord-010092-uftc8inx 2514 19 located locate VBN cord-010092-uftc8inx 2514 20 on on IN cord-010092-uftc8inx 2514 21 chromosome chromosome NN cord-010092-uftc8inx 2514 22 19 19 CD cord-010092-uftc8inx 2514 23 . . . cord-010092-uftc8inx 2515 1 Currently currently RB cord-010092-uftc8inx 2515 2 , , , cord-010092-uftc8inx 2515 3 ISBT ISBT NNP cord-010092-uftc8inx 2515 4 lists list VBZ cord-010092-uftc8inx 2515 5 20 20 CD cord-010092-uftc8inx 2515 6 high high JJ cord-010092-uftc8inx 2515 7 incidence incidence NN cord-010092-uftc8inx 2515 8 antigens antigen NNS cord-010092-uftc8inx 2515 9 in in IN cord-010092-uftc8inx 2515 10 the the DT cord-010092-uftc8inx 2515 11 system system NN cord-010092-uftc8inx 2515 12 . . . cord-010092-uftc8inx 2516 1 Aims aim VBZ cord-010092-uftc8inx 2516 2 : : : cord-010092-uftc8inx 2516 3 We -PRON- PRP cord-010092-uftc8inx 2516 4 report report VBP cord-010092-uftc8inx 2516 5 a a DT cord-010092-uftc8inx 2516 6 case case NN cord-010092-uftc8inx 2516 7 study study NN cord-010092-uftc8inx 2516 8 of of IN cord-010092-uftc8inx 2516 9 an an DT cord-010092-uftc8inx 2516 10 individual individual NN cord-010092-uftc8inx 2516 11 with with IN cord-010092-uftc8inx 2516 12 an an DT cord-010092-uftc8inx 2516 13 unidentified unidentified JJ cord-010092-uftc8inx 2516 14 alloantibody alloantibody NN cord-010092-uftc8inx 2516 15 to to IN cord-010092-uftc8inx 2516 16 high high JJ cord-010092-uftc8inx 2516 17 incidence incidence NN cord-010092-uftc8inx 2516 18 antigen antigen NN cord-010092-uftc8inx 2516 19 present present JJ cord-010092-uftc8inx 2516 20 in in IN cord-010092-uftc8inx 2516 21 her -PRON- PRP$ cord-010092-uftc8inx 2516 22 plasma plasma NN cord-010092-uftc8inx 2516 23 . . . cord-010092-uftc8inx 2517 1 Samples sample NNS cord-010092-uftc8inx 2517 2 from from IN cord-010092-uftc8inx 2517 3 the the DT cord-010092-uftc8inx 2517 4 patient patient NN cord-010092-uftc8inx 2517 5 and and CC cord-010092-uftc8inx 2517 6 her -PRON- PRP$ cord-010092-uftc8inx 2517 7 family family NN cord-010092-uftc8inx 2517 8 were be VBD cord-010092-uftc8inx 2517 9 investigated investigate VBN cord-010092-uftc8inx 2517 10 . . . cord-010092-uftc8inx 2518 1 We -PRON- PRP cord-010092-uftc8inx 2518 2 provide provide VBP cord-010092-uftc8inx 2518 3 here here RB cord-010092-uftc8inx 2518 4 serological serological JJ cord-010092-uftc8inx 2518 5 and and CC cord-010092-uftc8inx 2518 6 molecular molecular JJ cord-010092-uftc8inx 2518 7 evidence evidence NN cord-010092-uftc8inx 2518 8 for for IN cord-010092-uftc8inx 2518 9 a a DT cord-010092-uftc8inx 2518 10 novel novel JJ cord-010092-uftc8inx 2518 11 high high JJ cord-010092-uftc8inx 2518 12 incidence incidence NN cord-010092-uftc8inx 2518 13 antigen antigen NN cord-010092-uftc8inx 2518 14 of of IN cord-010092-uftc8inx 2518 15 the the DT cord-010092-uftc8inx 2518 16 Lutheran Lutheran NNP cord-010092-uftc8inx 2518 17 blood blood NN cord-010092-uftc8inx 2518 18 group group NN cord-010092-uftc8inx 2518 19 system system NN cord-010092-uftc8inx 2518 20 . . . cord-010092-uftc8inx 2519 1 Methods method NNS cord-010092-uftc8inx 2519 2 : : : cord-010092-uftc8inx 2519 3 Serological serological JJ cord-010092-uftc8inx 2519 4 investigations investigation NNS cord-010092-uftc8inx 2519 5 were be VBD cord-010092-uftc8inx 2519 6 performed perform VBN cord-010092-uftc8inx 2519 7 by by IN cord-010092-uftc8inx 2519 8 standard standard JJ cord-010092-uftc8inx 2519 9 IAT IAT NNP cord-010092-uftc8inx 2519 10 ( ( -LRB- cord-010092-uftc8inx 2519 11 LISS LISS NNP cord-010092-uftc8inx 2519 12 tube tube NN cord-010092-uftc8inx 2519 13 and and CC cord-010092-uftc8inx 2519 14 Bio Bio NNP cord-010092-uftc8inx 2519 15 - - HYPH cord-010092-uftc8inx 2519 16 Rad Rad NNP cord-010092-uftc8inx 2519 17 gel gel NN cord-010092-uftc8inx 2519 18 ) ) -RRB- cord-010092-uftc8inx 2519 19 technique technique NN cord-010092-uftc8inx 2519 20 . . . cord-010092-uftc8inx 2520 1 Plasma plasma NN cord-010092-uftc8inx 2520 2 inhibition inhibition NN cord-010092-uftc8inx 2520 3 studies study NNS cord-010092-uftc8inx 2520 4 were be VBD cord-010092-uftc8inx 2520 5 completed complete VBN cord-010092-uftc8inx 2520 6 with with IN cord-010092-uftc8inx 2520 7 soluble soluble JJ cord-010092-uftc8inx 2520 8 recombinant recombinant JJ cord-010092-uftc8inx 2520 9 Lu Lu NNP cord-010092-uftc8inx 2520 10 ( ( -LRB- cord-010092-uftc8inx 2520 11 srLu srLu NNP cord-010092-uftc8inx 2520 12 ) ) -RRB- cord-010092-uftc8inx 2520 13 protein protein NN cord-010092-uftc8inx 2520 14 . . . cord-010092-uftc8inx 2521 1 Genomic genomic JJ cord-010092-uftc8inx 2521 2 DNA dna NN cord-010092-uftc8inx 2521 3 was be VBD cord-010092-uftc8inx 2521 4 isolated isolate VBN cord-010092-uftc8inx 2521 5 from from IN cord-010092-uftc8inx 2521 6 whole whole JJ cord-010092-uftc8inx 2521 7 blood blood NN cord-010092-uftc8inx 2521 8 of of IN cord-010092-uftc8inx 2521 9 the the DT cord-010092-uftc8inx 2521 10 patient patient NN cord-010092-uftc8inx 2521 11 and and CC cord-010092-uftc8inx 2521 12 her -PRON- PRP$ cord-010092-uftc8inx 2521 13 family family NN cord-010092-uftc8inx 2521 14 members member NNS cord-010092-uftc8inx 2521 15 ; ; : cord-010092-uftc8inx 2521 16 all all PDT cord-010092-uftc8inx 2521 17 the the DT cord-010092-uftc8inx 2521 18 exons exon NNS cord-010092-uftc8inx 2521 19 of of IN cord-010092-uftc8inx 2521 20 the the DT cord-010092-uftc8inx 2521 21 BCAM BCAM NNP cord-010092-uftc8inx 2521 22 gene gene NN cord-010092-uftc8inx 2521 23 were be VBD cord-010092-uftc8inx 2521 24 amplified amplify VBN cord-010092-uftc8inx 2521 25 by by IN cord-010092-uftc8inx 2521 26 PCR PCR NNP cord-010092-uftc8inx 2521 27 and and CC cord-010092-uftc8inx 2521 28 analysed analyse VBN cord-010092-uftc8inx 2521 29 by by IN cord-010092-uftc8inx 2521 30 direct direct JJ cord-010092-uftc8inx 2521 31 Sanger Sanger NNP cord-010092-uftc8inx 2521 32 sequencing sequencing NN cord-010092-uftc8inx 2521 33 . . . cord-010092-uftc8inx 2522 1 The the DT cord-010092-uftc8inx 2522 2 impact impact NN cord-010092-uftc8inx 2522 3 of of IN cord-010092-uftc8inx 2522 4 the the DT cord-010092-uftc8inx 2522 5 identified identify VBN cord-010092-uftc8inx 2522 6 mutation mutation NN cord-010092-uftc8inx 2522 7 on on IN cord-010092-uftc8inx 2522 8 Lutheran Lutheran NNP cord-010092-uftc8inx 2522 9 glycoprotein glycoprotein NN cord-010092-uftc8inx 2522 10 structure structure NN cord-010092-uftc8inx 2522 11 was be VBD cord-010092-uftc8inx 2522 12 studied study VBN cord-010092-uftc8inx 2522 13 by by IN cord-010092-uftc8inx 2522 14 molecular molecular JJ cord-010092-uftc8inx 2522 15 dynamics dynamic NNS cord-010092-uftc8inx 2522 16 calculations calculation NNS cord-010092-uftc8inx 2522 17 . . . cord-010092-uftc8inx 2523 1 Results result NNS cord-010092-uftc8inx 2523 2 : : : cord-010092-uftc8inx 2524 1 Presence presence NN cord-010092-uftc8inx 2524 2 of of IN cord-010092-uftc8inx 2524 3 a a DT cord-010092-uftc8inx 2524 4 Lu Lu NNP cord-010092-uftc8inx 2524 5 - - HYPH cord-010092-uftc8inx 2524 6 related relate VBN cord-010092-uftc8inx 2524 7 antibody antibody NN cord-010092-uftc8inx 2524 8 in in IN cord-010092-uftc8inx 2524 9 the the DT cord-010092-uftc8inx 2524 10 patient patient NN cord-010092-uftc8inx 2524 11 's 's POS cord-010092-uftc8inx 2524 12 plasma plasma NN cord-010092-uftc8inx 2524 13 was be VBD cord-010092-uftc8inx 2524 14 confirmed confirm VBN cord-010092-uftc8inx 2524 15 , , , cord-010092-uftc8inx 2524 16 reacting react VBG cord-010092-uftc8inx 2524 17 moderate moderate JJ cord-010092-uftc8inx 2524 18 strength strength NN cord-010092-uftc8inx 2524 19 by by IN cord-010092-uftc8inx 2524 20 LISS LISS NNP cord-010092-uftc8inx 2524 21 IAT IAT NNP cord-010092-uftc8inx 2524 22 with with IN cord-010092-uftc8inx 2524 23 untreated untreated JJ cord-010092-uftc8inx 2524 24 and and CC cord-010092-uftc8inx 2524 25 papain papain NN cord-010092-uftc8inx 2524 26 treated treat VBN cord-010092-uftc8inx 2524 27 cells cell NNS cord-010092-uftc8inx 2524 28 . . . cord-010092-uftc8inx 2525 1 Cells cell NNS cord-010092-uftc8inx 2525 2 from from IN cord-010092-uftc8inx 2525 3 the the DT cord-010092-uftc8inx 2525 4 patient patient NN cord-010092-uftc8inx 2525 5 's 's POS cord-010092-uftc8inx 2525 6 mother mother NN cord-010092-uftc8inx 2525 7 , , , cord-010092-uftc8inx 2525 8 father father NN cord-010092-uftc8inx 2525 9 and and CC cord-010092-uftc8inx 2525 10 two two CD cord-010092-uftc8inx 2525 11 siblings sibling NNS cord-010092-uftc8inx 2525 12 were be VBD cord-010092-uftc8inx 2525 13 all all RB cord-010092-uftc8inx 2525 14 incompatible incompatible JJ cord-010092-uftc8inx 2525 15 with with IN cord-010092-uftc8inx 2525 16 her -PRON- PRP$ cord-010092-uftc8inx 2525 17 plasma plasma NN cord-010092-uftc8inx 2525 18 , , , cord-010092-uftc8inx 2525 19 though though IN cord-010092-uftc8inx 2525 20 weaker weak JJR cord-010092-uftc8inx 2525 21 than than IN cord-010092-uftc8inx 2525 22 panel panel NN cord-010092-uftc8inx 2525 23 cells cell NNS cord-010092-uftc8inx 2525 24 , , , cord-010092-uftc8inx 2525 25 reflecting reflect VBG cord-010092-uftc8inx 2525 26 dosage dosage NN cord-010092-uftc8inx 2525 27 . . . cord-010092-uftc8inx 2526 1 Only only RB cord-010092-uftc8inx 2526 2 In(Lu In(Lu NNP cord-010092-uftc8inx 2526 3 ) ) -RRB- cord-010092-uftc8inx 2526 4 cells cell NNS cord-010092-uftc8inx 2526 5 were be VBD cord-010092-uftc8inx 2526 6 compatible compatible JJ cord-010092-uftc8inx 2526 7 with with IN cord-010092-uftc8inx 2526 8 patient patient NN cord-010092-uftc8inx 2526 9 's 's POS cord-010092-uftc8inx 2526 10 plasma plasma NN cord-010092-uftc8inx 2526 11 . . . cord-010092-uftc8inx 2527 1 The the DT cord-010092-uftc8inx 2527 2 antibody antibody NN cord-010092-uftc8inx 2527 3 was be VBD cord-010092-uftc8inx 2527 4 successfully successfully RB cord-010092-uftc8inx 2527 5 inhibited inhibit VBN cord-010092-uftc8inx 2527 6 with with IN cord-010092-uftc8inx 2527 7 srLu srLu NNP cord-010092-uftc8inx 2527 8 protein protein NN cord-010092-uftc8inx 2527 9 , , , cord-010092-uftc8inx 2527 10 thereby thereby RB cord-010092-uftc8inx 2527 11 confirming confirm VBG cord-010092-uftc8inx 2527 12 the the DT cord-010092-uftc8inx 2527 13 epitope epitope NN cord-010092-uftc8inx 2527 14 recognised recognise VBN cord-010092-uftc8inx 2527 15 by by IN cord-010092-uftc8inx 2527 16 the the DT cord-010092-uftc8inx 2527 17 antibody antibody NN cord-010092-uftc8inx 2527 18 resides reside VBZ cord-010092-uftc8inx 2527 19 on on IN cord-010092-uftc8inx 2527 20 the the DT cord-010092-uftc8inx 2527 21 Lutheran Lutheran NNP cord-010092-uftc8inx 2527 22 glycoprotein glycoprotein NN cord-010092-uftc8inx 2527 23 . . . cord-010092-uftc8inx 2528 1 The the DT cord-010092-uftc8inx 2528 2 patient patient NN cord-010092-uftc8inx 2528 3 's 's POS cord-010092-uftc8inx 2528 4 cells cell NNS cord-010092-uftc8inx 2528 5 were be VBD cord-010092-uftc8inx 2528 6 found find VBN cord-010092-uftc8inx 2528 7 to to TO cord-010092-uftc8inx 2528 8 be be VB cord-010092-uftc8inx 2528 9 LU LU NNP cord-010092-uftc8inx 2528 10 : : : cord-010092-uftc8inx 2528 11 -1 -1 NN cord-010092-uftc8inx 2528 12 , , , cord-010092-uftc8inx 2528 13 2 2 CD cord-010092-uftc8inx 2528 14 , , , cord-010092-uftc8inx 2528 15 3 3 CD cord-010092-uftc8inx 2528 16 , , , cord-010092-uftc8inx 2528 17 5 5 CD cord-010092-uftc8inx 2528 18 , , , cord-010092-uftc8inx 2528 19 6 6 CD cord-010092-uftc8inx 2528 20 , , , cord-010092-uftc8inx 2528 21 8 8 CD cord-010092-uftc8inx 2528 22 , , , cord-010092-uftc8inx 2528 23 13 13 CD cord-010092-uftc8inx 2528 24 , , , cord-010092-uftc8inx 2528 25 20 20 CD cord-010092-uftc8inx 2528 26 , , , cord-010092-uftc8inx 2528 27 21 21 CD cord-010092-uftc8inx 2528 28 . . . cord-010092-uftc8inx 2529 1 BCAM BCAM NNP cord-010092-uftc8inx 2529 2 sequencing sequencing NN cord-010092-uftc8inx 2529 3 revealed reveal VBD cord-010092-uftc8inx 2529 4 a a DT cord-010092-uftc8inx 2529 5 novel novel JJ cord-010092-uftc8inx 2529 6 homozygous homozygous JJ cord-010092-uftc8inx 2529 7 mutation mutation NN cord-010092-uftc8inx 2529 8 c.121 c.121 NN cord-010092-uftc8inx 2529 9 G g NN cord-010092-uftc8inx 2530 1 > > XX cord-010092-uftc8inx 2531 1 A a DT cord-010092-uftc8inx 2531 2 in in IN cord-010092-uftc8inx 2531 3 exon exon NN cord-010092-uftc8inx 2531 4 2 2 CD cord-010092-uftc8inx 2531 5 , , , cord-010092-uftc8inx 2531 6 encoding encode VBG cord-010092-uftc8inx 2531 7 p. p. NN cord-010092-uftc8inx 2532 1 Val41Met Val41Met NNP cord-010092-uftc8inx 2532 2 in in IN cord-010092-uftc8inx 2532 3 the the DT cord-010092-uftc8inx 2532 4 Lu Lu NNP cord-010092-uftc8inx 2532 5 glycoprotein glycoprotein NN cord-010092-uftc8inx 2532 6 . . . cord-010092-uftc8inx 2533 1 The the DT cord-010092-uftc8inx 2533 2 c.121 c.121 NN cord-010092-uftc8inx 2533 3 G g NN cord-010092-uftc8inx 2534 1 > > XX cord-010092-uftc8inx 2535 1 A a DT cord-010092-uftc8inx 2535 2 change change NN cord-010092-uftc8inx 2535 3 appears appear VBZ cord-010092-uftc8inx 2535 4 to to TO cord-010092-uftc8inx 2535 5 be be VB cord-010092-uftc8inx 2535 6 an an DT cord-010092-uftc8inx 2535 7 extremely extremely RB cord-010092-uftc8inx 2535 8 rare rare JJ cord-010092-uftc8inx 2535 9 mutation mutation NN cord-010092-uftc8inx 2535 10 , , , cord-010092-uftc8inx 2535 11 listed list VBN cord-010092-uftc8inx 2535 12 in in IN cord-010092-uftc8inx 2535 13 gnomAD gnomAD NNP cord-010092-uftc8inx 2535 14 database database NN cord-010092-uftc8inx 2535 15 with with IN cord-010092-uftc8inx 2535 16 a a DT cord-010092-uftc8inx 2535 17 frequency frequency NN cord-010092-uftc8inx 2535 18 of of IN cord-010092-uftc8inx 2535 19 3.98 3.98 CD cord-010092-uftc8inx 2535 20 9 9 CD cord-010092-uftc8inx 2535 21 10 10 CD cord-010092-uftc8inx 2535 22 -6 -6 CD cord-010092-uftc8inx 2535 23 and and CC cord-010092-uftc8inx 2535 24 with with IN cord-010092-uftc8inx 2535 25 no no DT cord-010092-uftc8inx 2535 26 known know VBN cord-010092-uftc8inx 2535 27 homozygous homozygous JJ cord-010092-uftc8inx 2535 28 examples example NNS cord-010092-uftc8inx 2535 29 . . . cord-010092-uftc8inx 2536 1 Homology homology NN cord-010092-uftc8inx 2536 2 model model NN cord-010092-uftc8inx 2536 3 of of IN cord-010092-uftc8inx 2536 4 the the DT cord-010092-uftc8inx 2536 5 novel novel JJ cord-010092-uftc8inx 2536 6 Lutheran Lutheran NNP cord-010092-uftc8inx 2536 7 glycoprotein glycoprotein NN cord-010092-uftc8inx 2536 8 was be VBD cord-010092-uftc8inx 2536 9 subjected subject VBN cord-010092-uftc8inx 2536 10 to to IN cord-010092-uftc8inx 2536 11 all all DT cord-010092-uftc8inx 2536 12 - - HYPH cord-010092-uftc8inx 2536 13 atom atom NN cord-010092-uftc8inx 2536 14 molecular molecular JJ cord-010092-uftc8inx 2536 15 dynamics dynamic NNS cord-010092-uftc8inx 2536 16 calculations calculation NNS cord-010092-uftc8inx 2536 17 to to TO cord-010092-uftc8inx 2536 18 analyse analyse VB cord-010092-uftc8inx 2536 19 potential potential JJ cord-010092-uftc8inx 2536 20 conformational conformational JJ cord-010092-uftc8inx 2536 21 changes change NNS cord-010092-uftc8inx 2536 22 . . . cord-010092-uftc8inx 2537 1 Summary Summary NNP cord-010092-uftc8inx 2537 2 / / SYM cord-010092-uftc8inx 2537 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 2537 4 : : : cord-010092-uftc8inx 2538 1 We -PRON- PRP cord-010092-uftc8inx 2538 2 report report VBP cord-010092-uftc8inx 2538 3 serological serological JJ cord-010092-uftc8inx 2538 4 and and CC cord-010092-uftc8inx 2538 5 genetic genetic JJ cord-010092-uftc8inx 2538 6 evidence evidence NN cord-010092-uftc8inx 2538 7 for for IN cord-010092-uftc8inx 2538 8 a a DT cord-010092-uftc8inx 2538 9 novel novel JJ cord-010092-uftc8inx 2538 10 antigen antigen NN cord-010092-uftc8inx 2538 11 of of IN cord-010092-uftc8inx 2538 12 the the DT cord-010092-uftc8inx 2538 13 Lutheran Lutheran NNP cord-010092-uftc8inx 2538 14 system system NN cord-010092-uftc8inx 2538 15 , , , cord-010092-uftc8inx 2538 16 which which WDT cord-010092-uftc8inx 2538 17 we -PRON- PRP cord-010092-uftc8inx 2538 18 propose propose VBP cord-010092-uftc8inx 2538 19 to to TO cord-010092-uftc8inx 2538 20 name name VB cord-010092-uftc8inx 2538 21 LUNU LUNU NNP cord-010092-uftc8inx 2538 22 . . . cord-010092-uftc8inx 2539 1 The the DT cord-010092-uftc8inx 2539 2 evidence evidence NN cord-010092-uftc8inx 2539 3 will will MD cord-010092-uftc8inx 2539 4 be be VB cord-010092-uftc8inx 2539 5 submitted submit VBN cord-010092-uftc8inx 2539 6 to to IN cord-010092-uftc8inx 2539 7 the the DT cord-010092-uftc8inx 2539 8 ISBT ISBT NNP cord-010092-uftc8inx 2539 9 Red Red NNP cord-010092-uftc8inx 2539 10 Cell Cell NNP cord-010092-uftc8inx 2539 11 Immunogenetics Immunogenetics NNP cord-010092-uftc8inx 2539 12 and and CC cord-010092-uftc8inx 2539 13 Blood Blood NNP cord-010092-uftc8inx 2539 14 Group Group NNP cord-010092-uftc8inx 2539 15 Terminology Terminology NNP cord-010092-uftc8inx 2539 16 Working Working NNP cord-010092-uftc8inx 2539 17 Party Party NNP cord-010092-uftc8inx 2539 18 for for IN cord-010092-uftc8inx 2539 19 consideration consideration NN cord-010092-uftc8inx 2539 20 for for IN cord-010092-uftc8inx 2539 21 allocation allocation NN cord-010092-uftc8inx 2539 22 of of IN cord-010092-uftc8inx 2539 23 antigen antigen NN cord-010092-uftc8inx 2539 24 status status NN cord-010092-uftc8inx 2539 25 . . . cord-010092-uftc8inx 2540 1 The the DT cord-010092-uftc8inx 2540 2 absence absence NN cord-010092-uftc8inx 2540 3 of of IN cord-010092-uftc8inx 2540 4 this this DT cord-010092-uftc8inx 2540 5 high high JJ cord-010092-uftc8inx 2540 6 incidence incidence NN cord-010092-uftc8inx 2540 7 antigen antigen NN cord-010092-uftc8inx 2540 8 arises arise VBZ cord-010092-uftc8inx 2540 9 from from IN cord-010092-uftc8inx 2540 10 a a DT cord-010092-uftc8inx 2540 11 rare rare JJ cord-010092-uftc8inx 2540 12 single single JJ cord-010092-uftc8inx 2540 13 amino amino NN cord-010092-uftc8inx 2540 14 acid acid NN cord-010092-uftc8inx 2540 15 change change NN cord-010092-uftc8inx 2540 16 p. p. NN cord-010092-uftc8inx 2541 1 Val41Met Val41Met NNP cord-010092-uftc8inx 2541 2 in in IN cord-010092-uftc8inx 2541 3 the the DT cord-010092-uftc8inx 2541 4 Lutheran Lutheran NNP cord-010092-uftc8inx 2541 5 glycoprotein glycoprotein NN cord-010092-uftc8inx 2541 6 and and CC cord-010092-uftc8inx 2541 7 the the DT cord-010092-uftc8inx 2541 8 presence presence NN cord-010092-uftc8inx 2541 9 of of IN cord-010092-uftc8inx 2541 10 anti anti JJ cord-010092-uftc8inx 2541 11 - - NNP cord-010092-uftc8inx 2541 12 LUNU LUNU NNP cord-010092-uftc8inx 2541 13 in in IN cord-010092-uftc8inx 2541 14 the the DT cord-010092-uftc8inx 2541 15 patients patient NNS cord-010092-uftc8inx 2541 16 ' ' POS cord-010092-uftc8inx 2541 17 plasma plasma NN cord-010092-uftc8inx 2541 18 was be VBD cord-010092-uftc8inx 2541 19 presumed presume VBN cord-010092-uftc8inx 2541 20 to to TO cord-010092-uftc8inx 2541 21 have have VB cord-010092-uftc8inx 2541 22 been be VBN cord-010092-uftc8inx 2541 23 made make VBN cord-010092-uftc8inx 2541 24 in in IN cord-010092-uftc8inx 2541 25 response response NN cord-010092-uftc8inx 2541 26 to to IN cord-010092-uftc8inx 2541 27 previous previous JJ cord-010092-uftc8inx 2541 28 pregnancy pregnancy NN cord-010092-uftc8inx 2541 29 . . . cord-010092-uftc8inx 2542 1 on on IN cord-010092-uftc8inx 2542 2 native native JJ cord-010092-uftc8inx 2542 3 , , , cord-010092-uftc8inx 2542 4 papain papain NN cord-010092-uftc8inx 2542 5 - - HYPH cord-010092-uftc8inx 2542 6 treated treat VBN cord-010092-uftc8inx 2542 7 ( ( -LRB- cord-010092-uftc8inx 2542 8 Diagast Diagast NNP cord-010092-uftc8inx 2542 9 ) ) -RRB- cord-010092-uftc8inx 2542 10 and and CC cord-010092-uftc8inx 2542 11 trypsin trypsin NN cord-010092-uftc8inx 2542 12 - - HYPH cord-010092-uftc8inx 2542 13 treated treat VBN cord-010092-uftc8inx 2542 14 ( ( -LRB- cord-010092-uftc8inx 2542 15 Sigma Sigma NNP cord-010092-uftc8inx 2542 16 ) ) -RRB- cord-010092-uftc8inx 2542 17 RBCs rbc NNS cord-010092-uftc8inx 2542 18 . . . cord-010092-uftc8inx 2543 1 Genomic genomic JJ cord-010092-uftc8inx 2543 2 DNA dna NN cord-010092-uftc8inx 2543 3 was be VBD cord-010092-uftc8inx 2543 4 extracted extract VBN cord-010092-uftc8inx 2543 5 from from IN cord-010092-uftc8inx 2543 6 peripheral peripheral JJ cord-010092-uftc8inx 2543 7 blood blood NN cord-010092-uftc8inx 2543 8 cells cell NNS cord-010092-uftc8inx 2543 9 by by IN cord-010092-uftc8inx 2543 10 an an DT cord-010092-uftc8inx 2543 11 automated automate VBN cord-010092-uftc8inx 2543 12 method method NN cord-010092-uftc8inx 2543 13 , , , cord-010092-uftc8inx 2543 14 amplified amplify VBN cord-010092-uftc8inx 2543 15 by by IN cord-010092-uftc8inx 2543 16 SEMA7A SEMA7A NNP cord-010092-uftc8inx 2543 17 exon exon NN cord-010092-uftc8inx 2543 18 - - HYPH cord-010092-uftc8inx 2543 19 specific specific JJ cord-010092-uftc8inx 2543 20 primers primer NNS cord-010092-uftc8inx 2543 21 and and CC cord-010092-uftc8inx 2543 22 sequenced sequence VBN cord-010092-uftc8inx 2543 23 . . . cord-010092-uftc8inx 2544 1 Results result NNS cord-010092-uftc8inx 2544 2 : : : cord-010092-uftc8inx 2545 1 The the DT cord-010092-uftc8inx 2545 2 proband proband NN cord-010092-uftc8inx 2545 3 was be VBD cord-010092-uftc8inx 2545 4 a a DT cord-010092-uftc8inx 2545 5 32-year 32-year JJ cord-010092-uftc8inx 2545 6 - - HYPH cord-010092-uftc8inx 2545 7 old old JJ cord-010092-uftc8inx 2545 8 female female JJ cord-010092-uftc8inx 2545 9 patient patient NN cord-010092-uftc8inx 2545 10 of of IN cord-010092-uftc8inx 2545 11 Moroccan moroccan JJ cord-010092-uftc8inx 2545 12 origin origin NN cord-010092-uftc8inx 2545 13 , , , cord-010092-uftc8inx 2545 14 group group NN cord-010092-uftc8inx 2545 15 A A NNP cord-010092-uftc8inx 2545 16 , , , cord-010092-uftc8inx 2545 17 D+C+E D+C+E NNP cord-010092-uftc8inx 2545 18 - - HYPH cord-010092-uftc8inx 2545 19 c+e+ c+e+ NNP cord-010092-uftc8inx 2545 20 , , , cord-010092-uftc8inx 2545 21 K- K- NNP cord-010092-uftc8inx 2545 22 , , , cord-010092-uftc8inx 2545 23 without without IN cord-010092-uftc8inx 2545 24 transfusion transfusion NN cord-010092-uftc8inx 2545 25 history history NN cord-010092-uftc8inx 2545 26 . . . cord-010092-uftc8inx 2546 1 She -PRON- PRP cord-010092-uftc8inx 2546 2 was be VBD cord-010092-uftc8inx 2546 3 hospitalized hospitalize VBN cord-010092-uftc8inx 2546 4 at at IN cord-010092-uftc8inx 2546 5 27 27 CD cord-010092-uftc8inx 2546 6 weeks week NNS cord-010092-uftc8inx 2546 7 gestation gestation NN cord-010092-uftc8inx 2546 8 for for IN cord-010092-uftc8inx 2546 9 a a DT cord-010092-uftc8inx 2546 10 blighted blighted JJ cord-010092-uftc8inx 2546 11 ovum ovum NN cord-010092-uftc8inx 2546 12 requiring require VBG cord-010092-uftc8inx 2546 13 a a DT cord-010092-uftc8inx 2546 14 manual manual JJ cord-010092-uftc8inx 2546 15 vacuum vacuum NN cord-010092-uftc8inx 2546 16 aspiration aspiration NN cord-010092-uftc8inx 2546 17 , , , cord-010092-uftc8inx 2546 18 with with IN cord-010092-uftc8inx 2546 19 a a DT cord-010092-uftc8inx 2546 20 significant significant JJ cord-010092-uftc8inx 2546 21 hemorrhage hemorrhage NN cord-010092-uftc8inx 2546 22 risk risk NN cord-010092-uftc8inx 2546 23 . . . cord-010092-uftc8inx 2547 1 A a DT cord-010092-uftc8inx 2547 2 RBC RBC NNP cord-010092-uftc8inx 2547 3 antibody antibody NN cord-010092-uftc8inx 2547 4 screening screening NN cord-010092-uftc8inx 2547 5 was be VBD cord-010092-uftc8inx 2547 6 performed perform VBN cord-010092-uftc8inx 2547 7 by by IN cord-010092-uftc8inx 2547 8 a a DT cord-010092-uftc8inx 2547 9 first first JJ cord-010092-uftc8inx 2547 10 laboratory laboratory NN cord-010092-uftc8inx 2547 11 . . . cord-010092-uftc8inx 2548 1 The the DT cord-010092-uftc8inx 2548 2 antibody antibody NN cord-010092-uftc8inx 2548 3 reacted react VBD cord-010092-uftc8inx 2548 4 1 1 CD cord-010092-uftc8inx 2548 5 + + SYM cord-010092-uftc8inx 2548 6 by by IN cord-010092-uftc8inx 2548 7 IAT IAT NNP cord-010092-uftc8inx 2548 8 on on IN cord-010092-uftc8inx 2548 9 all all DT cord-010092-uftc8inx 2548 10 native native JJ cord-010092-uftc8inx 2548 11 reagent reagent NN cord-010092-uftc8inx 2548 12 RBCs rbc NNS cord-010092-uftc8inx 2548 13 , , , cord-010092-uftc8inx 2548 14 with with IN cord-010092-uftc8inx 2548 15 negative negative JJ cord-010092-uftc8inx 2548 16 autocontrols autocontrol NNS cord-010092-uftc8inx 2548 17 , , , cord-010092-uftc8inx 2548 18 but but CC cord-010092-uftc8inx 2548 19 was be VBD cord-010092-uftc8inx 2548 20 nonreactive nonreactive JJ cord-010092-uftc8inx 2548 21 on on IN cord-010092-uftc8inx 2548 22 papain papain NN cord-010092-uftc8inx 2548 23 - - HYPH cord-010092-uftc8inx 2548 24 and and CC cord-010092-uftc8inx 2548 25 trypsin trypsin NN cord-010092-uftc8inx 2548 26 - - HYPH cord-010092-uftc8inx 2548 27 treated treat VBN cord-010092-uftc8inx 2548 28 cells cell NNS cord-010092-uftc8inx 2548 29 . . . cord-010092-uftc8inx 2549 1 An an DT cord-010092-uftc8inx 2549 2 anti anti JJ cord-010092-uftc8inx 2549 3 - - JJ cord-010092-uftc8inx 2549 4 Ge2 ge2 NN cord-010092-uftc8inx 2549 5 was be VBD cord-010092-uftc8inx 2549 6 initially initially RB cord-010092-uftc8inx 2549 7 suspected suspect VBN cord-010092-uftc8inx 2549 8 , , , cord-010092-uftc8inx 2549 9 due due IN cord-010092-uftc8inx 2549 10 to to IN cord-010092-uftc8inx 2549 11 the the DT cord-010092-uftc8inx 2549 12 pattern pattern NN cord-010092-uftc8inx 2549 13 of of IN cord-010092-uftc8inx 2549 14 reactivity reactivity NN cord-010092-uftc8inx 2549 15 and and CC cord-010092-uftc8inx 2549 16 ethnic ethnic JJ cord-010092-uftc8inx 2549 17 background background NN cord-010092-uftc8inx 2549 18 . . . cord-010092-uftc8inx 2550 1 New new JJ cord-010092-uftc8inx 2550 2 blood blood NN cord-010092-uftc8inx 2550 3 samples sample NNS cord-010092-uftc8inx 2550 4 were be VBD cord-010092-uftc8inx 2550 5 referred refer VBN cord-010092-uftc8inx 2550 6 to to IN cord-010092-uftc8inx 2550 7 our -PRON- PRP$ cord-010092-uftc8inx 2550 8 national national JJ cord-010092-uftc8inx 2550 9 immunohematology immunohematology NN cord-010092-uftc8inx 2550 10 reference reference NN cord-010092-uftc8inx 2550 11 laboratory laboratory NN cord-010092-uftc8inx 2550 12 . . . cord-010092-uftc8inx 2551 1 The the DT cord-010092-uftc8inx 2551 2 antibody antibody NN cord-010092-uftc8inx 2551 3 showed show VBD cord-010092-uftc8inx 2551 4 the the DT cord-010092-uftc8inx 2551 5 same same JJ cord-010092-uftc8inx 2551 6 profile profile NN cord-010092-uftc8inx 2551 7 . . . cord-010092-uftc8inx 2552 1 Anti anti JJ cord-010092-uftc8inx 2552 2 - - JJ cord-010092-uftc8inx 2552 3 Ge2 ge2 JJ cord-010092-uftc8inx 2552 4 and and CC cord-010092-uftc8inx 2552 5 anti anti JJ cord-010092-uftc8inx 2552 6 - - JJ cord-010092-uftc8inx 2552 7 Ch1 ch1 JJ cord-010092-uftc8inx 2552 8 could could MD cord-010092-uftc8inx 2552 9 be be VB cord-010092-uftc8inx 2552 10 ruled rule VBN cord-010092-uftc8inx 2552 11 out out RP cord-010092-uftc8inx 2552 12 . . . cord-010092-uftc8inx 2553 1 The the DT cord-010092-uftc8inx 2553 2 serum serum NN cord-010092-uftc8inx 2553 3 was be VBD cord-010092-uftc8inx 2553 4 nonreactive nonreactive JJ cord-010092-uftc8inx 2553 5 with with IN cord-010092-uftc8inx 2553 6 two two CD cord-010092-uftc8inx 2553 7 JMH:-1 JMH:-1 NNP cord-010092-uftc8inx 2553 8 and and CC cord-010092-uftc8inx 2553 9 positive positive JJ cord-010092-uftc8inx 2553 10 with with IN cord-010092-uftc8inx 2553 11 two two CD cord-010092-uftc8inx 2553 12 JMH:-3 JMH:-3 NNP cord-010092-uftc8inx 2553 13 samples sample NNS cord-010092-uftc8inx 2553 14 . . . cord-010092-uftc8inx 2554 1 The the DT cord-010092-uftc8inx 2554 2 patient patient NN cord-010092-uftc8inx 2554 3 was be VBD cord-010092-uftc8inx 2554 4 found find VBN cord-010092-uftc8inx 2554 5 to to TO cord-010092-uftc8inx 2554 6 be be VB cord-010092-uftc8inx 2554 7 JMH1 JMH1 NNP cord-010092-uftc8inx 2554 8 positive positive JJ cord-010092-uftc8inx 2554 9 . . . cord-010092-uftc8inx 2555 1 In in IN cord-010092-uftc8inx 2555 2 addition addition NN cord-010092-uftc8inx 2555 3 , , , cord-010092-uftc8inx 2555 4 a a DT cord-010092-uftc8inx 2555 5 soluble soluble JJ cord-010092-uftc8inx 2555 6 recombinant recombinant JJ cord-010092-uftc8inx 2555 7 JMH JMH NNP cord-010092-uftc8inx 2555 8 protein protein NN cord-010092-uftc8inx 2555 9 ( ( -LRB- cord-010092-uftc8inx 2555 10 JMH JMH NNP cord-010092-uftc8inx 2555 11 Imusyn Imusyn NNP cord-010092-uftc8inx 2555 12 / / SYM cord-010092-uftc8inx 2555 13 Inno Inno NNP cord-010092-uftc8inx 2555 14 - - HYPH cord-010092-uftc8inx 2555 15 train train NN cord-010092-uftc8inx 2555 16 ) ) -RRB- cord-010092-uftc8inx 2555 17 fully fully RB cord-010092-uftc8inx 2555 18 abolished abolish VBD cord-010092-uftc8inx 2555 19 the the DT cord-010092-uftc8inx 2555 20 reactivity reactivity NN cord-010092-uftc8inx 2555 21 of of IN cord-010092-uftc8inx 2555 22 the the DT cord-010092-uftc8inx 2555 23 panagglutinating panagglutinate VBG cord-010092-uftc8inx 2555 24 antibody antibody NN cord-010092-uftc8inx 2555 25 . . . cord-010092-uftc8inx 2556 1 The the DT cord-010092-uftc8inx 2556 2 antibody antibody NN cord-010092-uftc8inx 2556 3 was be VBD cord-010092-uftc8inx 2556 4 an an DT cord-010092-uftc8inx 2556 5 IgG4 igg4 NN cord-010092-uftc8inx 2556 6 . . . cord-010092-uftc8inx 2557 1 Overall overall RB cord-010092-uftc8inx 2557 2 , , , cord-010092-uftc8inx 2557 3 these these DT cord-010092-uftc8inx 2557 4 results result NNS cord-010092-uftc8inx 2557 5 were be VBD cord-010092-uftc8inx 2557 6 consistent consistent JJ cord-010092-uftc8inx 2557 7 with with IN cord-010092-uftc8inx 2557 8 a a DT cord-010092-uftc8inx 2557 9 probable probable JJ cord-010092-uftc8inx 2557 10 JMH JMH NNP cord-010092-uftc8inx 2557 11 variant variant NN cord-010092-uftc8inx 2557 12 and and CC cord-010092-uftc8inx 2557 13 prompted prompt VBD cord-010092-uftc8inx 2557 14 us -PRON- PRP cord-010092-uftc8inx 2557 15 to to TO cord-010092-uftc8inx 2557 16 perform perform VB cord-010092-uftc8inx 2557 17 SEMA7A sema7a NN cord-010092-uftc8inx 2557 18 sequencing sequencing NN cord-010092-uftc8inx 2557 19 . . . cord-010092-uftc8inx 2558 1 Three three CD cord-010092-uftc8inx 2558 2 nucleotide nucleotide JJ cord-010092-uftc8inx 2558 3 changes change NNS cord-010092-uftc8inx 2558 4 were be VBD cord-010092-uftc8inx 2558 5 found find VBN cord-010092-uftc8inx 2558 6 , , , cord-010092-uftc8inx 2558 7 in in IN cord-010092-uftc8inx 2558 8 homozygous homozygous JJ cord-010092-uftc8inx 2558 9 state state NN cord-010092-uftc8inx 2558 10 : : : cord-010092-uftc8inx 2558 11 a a DT cord-010092-uftc8inx 2558 12 rare rare JJ cord-010092-uftc8inx 2558 13 nonsynonymous nonsynonymous JJ cord-010092-uftc8inx 2558 14 change change NN cord-010092-uftc8inx 2558 15 in in IN cord-010092-uftc8inx 2558 16 exon exon NN cord-010092-uftc8inx 2558 17 7 7 CD cord-010092-uftc8inx 2558 18 , , , cord-010092-uftc8inx 2558 19 c.709 c.709 NNP cord-010092-uftc8inx 2558 20 G g NN cord-010092-uftc8inx 2559 1 > > XX cord-010092-uftc8inx 2560 1 A a DT cord-010092-uftc8inx 2560 2 ( ( -LRB- cord-010092-uftc8inx 2560 3 p. p. NN cord-010092-uftc8inx 2561 1 Asp237Asn Asp237Asn NNP cord-010092-uftc8inx 2561 2 , , , cord-010092-uftc8inx 2561 3 rs140707085 rs140707085 NNP cord-010092-uftc8inx 2561 4 , , , cord-010092-uftc8inx 2562 1 MAF MAF NNP cord-010092-uftc8inx 2562 2 < < XX cord-010092-uftc8inx 2562 3 0.01 0.01 CD cord-010092-uftc8inx 2562 4 , , , cord-010092-uftc8inx 2562 5 SIFT sift VB cord-010092-uftc8inx 2562 6 score score NN cord-010092-uftc8inx 2562 7 = = SYM cord-010092-uftc8inx 2562 8 1 1 CD cord-010092-uftc8inx 2562 9 ) ) -RRB- cord-010092-uftc8inx 2562 10 ; ; : cord-010092-uftc8inx 2562 11 a a DT cord-010092-uftc8inx 2562 12 common common JJ cord-010092-uftc8inx 2562 13 synonymous synonymous JJ cord-010092-uftc8inx 2562 14 change change NN cord-010092-uftc8inx 2562 15 in in IN cord-010092-uftc8inx 2562 16 exon exon NN cord-010092-uftc8inx 2562 17 12 12 CD cord-010092-uftc8inx 2562 18 , , , cord-010092-uftc8inx 2562 19 c.1545A c.1545A NNP cord-010092-uftc8inx 2562 20 > > XX cord-010092-uftc8inx 2563 1 G G NNP cord-010092-uftc8inx 2563 2 ( ( -LRB- cord-010092-uftc8inx 2563 3 p. p. NN cord-010092-uftc8inx 2564 1 Gln515Gln Gln515Gln NNP cord-010092-uftc8inx 2564 2 , , , cord-010092-uftc8inx 2564 3 rs741761 rs741761 NNP cord-010092-uftc8inx 2564 4 , , , cord-010092-uftc8inx 2564 5 MAF MAF NNP cord-010092-uftc8inx 2564 6 = = SYM cord-010092-uftc8inx 2564 7 0.5 0.5 CD cord-010092-uftc8inx 2564 8 ) ) -RRB- cord-010092-uftc8inx 2564 9 ; ; : cord-010092-uftc8inx 2564 10 a a DT cord-010092-uftc8inx 2564 11 rare rare JJ cord-010092-uftc8inx 2564 12 non non JJ cord-010092-uftc8inx 2564 13 - - JJ cord-010092-uftc8inx 2564 14 synonymous synonymous JJ cord-010092-uftc8inx 2564 15 change change NN cord-010092-uftc8inx 2564 16 in in IN cord-010092-uftc8inx 2564 17 exon exon NN cord-010092-uftc8inx 2564 18 14 14 CD cord-010092-uftc8inx 2564 19 , , , cord-010092-uftc8inx 2564 20 c.1865 c.1865 JJ cord-010092-uftc8inx 2564 21 G g NN cord-010092-uftc8inx 2564 22 > > XX cord-010092-uftc8inx 2565 1 A a DT cord-010092-uftc8inx 2565 2 ( ( -LRB- cord-010092-uftc8inx 2565 3 p. p. NN cord-010092-uftc8inx 2566 1 Arg622His arg622his NN cord-010092-uftc8inx 2566 2 , , , cord-010092-uftc8inx 2566 3 rs140128092 rs140128092 NNP cord-010092-uftc8inx 2566 4 , , , cord-010092-uftc8inx 2567 1 MAF MAF NNP cord-010092-uftc8inx 2567 2 < < XX cord-010092-uftc8inx 2567 3 0.01 0.01 CD cord-010092-uftc8inx 2567 4 , , , cord-010092-uftc8inx 2567 5 SIFT sift VB cord-010092-uftc8inx 2567 6 score score NN cord-010092-uftc8inx 2567 7 = = SYM cord-010092-uftc8inx 2567 8 0.36 0.36 CD cord-010092-uftc8inx 2567 9 ) ) -RRB- cord-010092-uftc8inx 2567 10 . . . cord-010092-uftc8inx 2568 1 The the DT cord-010092-uftc8inx 2568 2 analysis analysis NN cord-010092-uftc8inx 2568 3 of of IN cord-010092-uftc8inx 2568 4 surface surface NN cord-010092-uftc8inx 2568 5 accessibility accessibility NN cord-010092-uftc8inx 2568 6 of of IN cord-010092-uftc8inx 2568 7 Asp Asp NNP cord-010092-uftc8inx 2568 8 237 237 CD cord-010092-uftc8inx 2568 9 and and CC cord-010092-uftc8inx 2568 10 Arg Arg NNP cord-010092-uftc8inx 2568 11 622 622 CD cord-010092-uftc8inx 2568 12 using use VBG cord-010092-uftc8inx 2568 13 the the DT cord-010092-uftc8inx 2568 14 3D 3d JJ cord-010092-uftc8inx 2568 15 structure structure NN cord-010092-uftc8inx 2568 16 of of IN cord-010092-uftc8inx 2568 17 Sema7A Sema7A NNP cord-010092-uftc8inx 2568 18 ( ( -LRB- cord-010092-uftc8inx 2568 19 RCSB RCSB NNP cord-010092-uftc8inx 2568 20 PDB-3NVQ PDB-3NVQ NNP cord-010092-uftc8inx 2568 21 https://www.rcsb.org/structure/3nvq https://www.rcsb.org/structure/3nvq NNP cord-010092-uftc8inx 2568 22 ) ) -RRB- cord-010092-uftc8inx 2568 23 showed show VBD cord-010092-uftc8inx 2568 24 that that IN cord-010092-uftc8inx 2568 25 only only RB cord-010092-uftc8inx 2568 26 Arg arg NN cord-010092-uftc8inx 2568 27 622 622 CD cord-010092-uftc8inx 2568 28 was be VBD cord-010092-uftc8inx 2568 29 predicted predict VBN cord-010092-uftc8inx 2568 30 to to TO cord-010092-uftc8inx 2568 31 be be VB cord-010092-uftc8inx 2568 32 an an DT cord-010092-uftc8inx 2568 33 exposed expose VBN cord-010092-uftc8inx 2568 34 - - HYPH cord-010092-uftc8inx 2568 35 epitope epitope NN cord-010092-uftc8inx 2568 36 . . . cord-010092-uftc8inx 2569 1 Interestingly interestingly RB cord-010092-uftc8inx 2569 2 , , , cord-010092-uftc8inx 2569 3 all all DT cord-010092-uftc8inx 2569 4 other other JJ cord-010092-uftc8inx 2569 5 reported report VBD cord-010092-uftc8inx 2569 6 JMH JMH NNP cord-010092-uftc8inx 2569 7 variant variant NN cord-010092-uftc8inx 2569 8 phenotypes phenotype NNS cord-010092-uftc8inx 2569 9 correspond correspond VBP cord-010092-uftc8inx 2569 10 to to IN cord-010092-uftc8inx 2569 11 an an DT cord-010092-uftc8inx 2569 12 arginine arginine NN cord-010092-uftc8inx 2569 13 substitution substitution NN cord-010092-uftc8inx 2569 14 . . . cord-010092-uftc8inx 2570 1 Of of IN cord-010092-uftc8inx 2570 2 note note NN cord-010092-uftc8inx 2570 3 , , , cord-010092-uftc8inx 2570 4 we -PRON- PRP cord-010092-uftc8inx 2570 5 retrospectively retrospectively RB cord-010092-uftc8inx 2570 6 found find VBD cord-010092-uftc8inx 2570 7 another another DT cord-010092-uftc8inx 2570 8 individual individual NN cord-010092-uftc8inx 2570 9 of of IN cord-010092-uftc8inx 2570 10 Algerian algerian JJ cord-010092-uftc8inx 2570 11 ancestry ancestry NN cord-010092-uftc8inx 2570 12 ( ( -LRB- cord-010092-uftc8inx 2570 13 pregnant pregnant JJ cord-010092-uftc8inx 2570 14 woman woman NN cord-010092-uftc8inx 2570 15 ) ) -RRB- cord-010092-uftc8inx 2570 16 with with IN cord-010092-uftc8inx 2570 17 a a DT cord-010092-uftc8inx 2570 18 pan pan JJ cord-010092-uftc8inx 2570 19 - - JJ cord-010092-uftc8inx 2570 20 agglutinating agglutinate VBG cord-010092-uftc8inx 2570 21 IgG4 igg4 JJ cord-010092-uftc8inx 2570 22 antibody antibody NN cord-010092-uftc8inx 2570 23 showing show VBG cord-010092-uftc8inx 2570 24 a a DT cord-010092-uftc8inx 2570 25 similar similar JJ cord-010092-uftc8inx 2570 26 pattern pattern NN cord-010092-uftc8inx 2570 27 of of IN cord-010092-uftc8inx 2570 28 reactivity reactivity NN cord-010092-uftc8inx 2570 29 , , , cord-010092-uftc8inx 2570 30 and and CC cord-010092-uftc8inx 2570 31 with with IN cord-010092-uftc8inx 2570 32 the the DT cord-010092-uftc8inx 2570 33 same same JJ cord-010092-uftc8inx 2570 34 three three CD cord-010092-uftc8inx 2570 35 changes change NNS cord-010092-uftc8inx 2570 36 in in IN cord-010092-uftc8inx 2570 37 SEMA7A. SEMA7A. NNS cord-010092-uftc8inx 2571 1 We -PRON- PRP cord-010092-uftc8inx 2571 2 unfortunately unfortunately RB cord-010092-uftc8inx 2571 3 could could MD cord-010092-uftc8inx 2571 4 not not RB cord-010092-uftc8inx 2571 5 perform perform VB cord-010092-uftc8inx 2571 6 a a DT cord-010092-uftc8inx 2571 7 cross cross NN cord-010092-uftc8inx 2571 8 - - JJ cord-010092-uftc8inx 2571 9 compatibility compatibility JJ cord-010092-uftc8inx 2571 10 testing testing NN cord-010092-uftc8inx 2571 11 with with IN cord-010092-uftc8inx 2571 12 the the DT cord-010092-uftc8inx 2571 13 proband proband NN cord-010092-uftc8inx 2571 14 ( ( -LRB- cord-010092-uftc8inx 2571 15 no no DT cord-010092-uftc8inx 2571 16 material material NN cord-010092-uftc8inx 2571 17 left leave VBN cord-010092-uftc8inx 2571 18 and and CC cord-010092-uftc8inx 2571 19 unsuccessful unsuccessful JJ cord-010092-uftc8inx 2571 20 contact contact NN cord-010092-uftc8inx 2571 21 ) ) -RRB- cord-010092-uftc8inx 2571 22 . . . cord-010092-uftc8inx 2572 1 Summary Summary NNP cord-010092-uftc8inx 2572 2 / / SYM cord-010092-uftc8inx 2572 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 2572 4 : : : cord-010092-uftc8inx 2573 1 Serological serological JJ cord-010092-uftc8inx 2573 2 and and CC cord-010092-uftc8inx 2573 3 molecular molecular JJ cord-010092-uftc8inx 2573 4 studies study NNS cord-010092-uftc8inx 2573 5 allowed allow VBD cord-010092-uftc8inx 2573 6 us -PRON- PRP cord-010092-uftc8inx 2573 7 to to TO cord-010092-uftc8inx 2573 8 provide provide VB cord-010092-uftc8inx 2573 9 evidence evidence NN cord-010092-uftc8inx 2573 10 for for IN cord-010092-uftc8inx 2573 11 a a DT cord-010092-uftc8inx 2573 12 novel novel JJ cord-010092-uftc8inx 2573 13 high high JJ cord-010092-uftc8inx 2573 14 - - HYPH cord-010092-uftc8inx 2573 15 prevalence prevalence NN cord-010092-uftc8inx 2573 16 antigen antigen NN cord-010092-uftc8inx 2573 17 in in IN cord-010092-uftc8inx 2573 18 the the DT cord-010092-uftc8inx 2573 19 JMH JMH NNP cord-010092-uftc8inx 2573 20 blood blood NN cord-010092-uftc8inx 2573 21 group group NN cord-010092-uftc8inx 2573 22 system system NN cord-010092-uftc8inx 2573 23 , , , cord-010092-uftc8inx 2573 24 very very RB cord-010092-uftc8inx 2573 25 likely likely RB cord-010092-uftc8inx 2573 26 encoded encode VBN cord-010092-uftc8inx 2573 27 by by IN cord-010092-uftc8inx 2573 28 the the DT cord-010092-uftc8inx 2573 29 p. p. NN cord-010092-uftc8inx 2574 1 Arg622His arg622his NN cord-010092-uftc8inx 2574 2 substitution substitution NN cord-010092-uftc8inx 2574 3 in in IN cord-010092-uftc8inx 2574 4 Sema7A. Sema7A. NNS cord-010092-uftc8inx 2575 1 We -PRON- PRP cord-010092-uftc8inx 2575 2 propose propose VBP cord-010092-uftc8inx 2575 3 to to TO cord-010092-uftc8inx 2575 4 provisionally provisionally RB cord-010092-uftc8inx 2575 5 assign assign VB cord-010092-uftc8inx 2575 6 the the DT cord-010092-uftc8inx 2575 7 name name NN cord-010092-uftc8inx 2575 8 JMH7 JMH7 NNP cord-010092-uftc8inx 2575 9 for for IN cord-010092-uftc8inx 2575 10 this this DT cord-010092-uftc8inx 2575 11 antigen antigen NN cord-010092-uftc8inx 2575 12 . . . cord-010092-uftc8inx 2576 1 Interestingly interestingly RB cord-010092-uftc8inx 2576 2 , , , cord-010092-uftc8inx 2576 3 our -PRON- PRP$ cord-010092-uftc8inx 2576 4 two two CD cord-010092-uftc8inx 2576 5 unrelated unrelated JJ cord-010092-uftc8inx 2576 6 JMH:-7 JMH:-7 NNP cord-010092-uftc8inx 2576 7 individuals individual NNS cord-010092-uftc8inx 2576 8 were be VBD cord-010092-uftc8inx 2576 9 from from IN cord-010092-uftc8inx 2576 10 North north JJ cord-010092-uftc8inx 2576 11 African african JJ cord-010092-uftc8inx 2576 12 ancestry ancestry NN cord-010092-uftc8inx 2576 13 . . . cord-010092-uftc8inx 2577 1 Background background NN cord-010092-uftc8inx 2577 2 : : : cord-010092-uftc8inx 2578 1 The the DT cord-010092-uftc8inx 2578 2 ABO ABO NNP cord-010092-uftc8inx 2578 3 system system NN cord-010092-uftc8inx 2578 4 was be VBD cord-010092-uftc8inx 2578 5 discovered discover VBN cord-010092-uftc8inx 2578 6 almost almost RB cord-010092-uftc8inx 2578 7 120 120 CD cord-010092-uftc8inx 2578 8 years year NNS cord-010092-uftc8inx 2578 9 ago ago RB cord-010092-uftc8inx 2578 10 and and CC cord-010092-uftc8inx 2578 11 the the DT cord-010092-uftc8inx 2578 12 underlying underlie VBG cord-010092-uftc8inx 2578 13 structures structure NNS cord-010092-uftc8inx 2578 14 later later RB cord-010092-uftc8inx 2578 15 elucidated elucidate VBN cord-010092-uftc8inx 2578 16 as as IN cord-010092-uftc8inx 2578 17 carbohydrates carbohydrate NNS cord-010092-uftc8inx 2578 18 carried carry VBN cord-010092-uftc8inx 2578 19 by by IN cord-010092-uftc8inx 2578 20 glycoproteins glycoprotein NNS cord-010092-uftc8inx 2578 21 and and CC cord-010092-uftc8inx 2578 22 glycolipids glycolipid NNS cord-010092-uftc8inx 2578 23 . . . cord-010092-uftc8inx 2579 1 The the DT cord-010092-uftc8inx 2579 2 terminal terminal NN cord-010092-uftc8inx 2579 3 trisaccharides trisaccharide NNS cord-010092-uftc8inx 2579 4 GalNAca3(Fuca2)Gal galnaca3(fuca2)gal NN cord-010092-uftc8inx 2579 5 and and CC cord-010092-uftc8inx 2579 6 Gala3(Fuca2)Gal Gala3(Fuca2)Gal NNP cord-010092-uftc8inx 2580 1 constitute constitute VB cord-010092-uftc8inx 2580 2 the the DT cord-010092-uftc8inx 2580 3 clinically clinically RB cord-010092-uftc8inx 2580 4 important important JJ cord-010092-uftc8inx 2580 5 A a NN cord-010092-uftc8inx 2580 6 and and CC cord-010092-uftc8inx 2580 7 B b NN cord-010092-uftc8inx 2580 8 epitopes epitope NNS cord-010092-uftc8inx 2580 9 , , , cord-010092-uftc8inx 2580 10 respectively respectively RB cord-010092-uftc8inx 2580 11 . . . cord-010092-uftc8inx 2581 1 Clausen Clausen NNP cord-010092-uftc8inx 2581 2 et et NNP cord-010092-uftc8inx 2581 3 al al NNP cord-010092-uftc8inx 2581 4 . . . cord-010092-uftc8inx 2582 1 ( ( -LRB- cord-010092-uftc8inx 2582 2 PNAS PNAS NNP cord-010092-uftc8inx 2582 3 , , , cord-010092-uftc8inx 2582 4 1985 1985 CD cord-010092-uftc8inx 2582 5 ) ) -RRB- cord-010092-uftc8inx 2582 6 showed show VBD cord-010092-uftc8inx 2582 7 that that IN cord-010092-uftc8inx 2582 8 the the DT cord-010092-uftc8inx 2582 9 A a DT cord-010092-uftc8inx 2582 10 antigen antigen NN cord-010092-uftc8inx 2582 11 could could MD cord-010092-uftc8inx 2582 12 be be VB cord-010092-uftc8inx 2582 13 extended extend VBN cord-010092-uftc8inx 2582 14 to to IN cord-010092-uftc8inx 2582 15 a a DT cord-010092-uftc8inx 2582 16 repetitive repetitive JJ cord-010092-uftc8inx 2582 17 glycolipid glycolipid NN cord-010092-uftc8inx 2582 18 A a DT cord-010092-uftc8inx 2582 19 epitope epitope NN cord-010092-uftc8inx 2582 20 , , , cord-010092-uftc8inx 2582 21 GalNAca3(Fuca2)Galb3GalNAca3(Fuca2)Galb4GlcNAc GalNAca3(Fuca2)Galb3GalNAca3(Fuca2)Galb4GlcNAc NNP cord-010092-uftc8inx 2582 22 - - HYPH cord-010092-uftc8inx 2582 23 R. R. NNP cord-010092-uftc8inx 2583 1 However however RB cord-010092-uftc8inx 2583 2 , , , cord-010092-uftc8inx 2583 3 extended extended JJ cord-010092-uftc8inx 2583 4 forms form NNS cord-010092-uftc8inx 2583 5 of of IN cord-010092-uftc8inx 2583 6 B b NN cord-010092-uftc8inx 2583 7 antigen antigen NN cord-010092-uftc8inx 2583 8 have have VBP cord-010092-uftc8inx 2583 9 not not RB cord-010092-uftc8inx 2583 10 been be VBN cord-010092-uftc8inx 2583 11 described describe VBN cord-010092-uftc8inx 2583 12 . . . cord-010092-uftc8inx 2584 1 We -PRON- PRP cord-010092-uftc8inx 2584 2 encountered encounter VBD cord-010092-uftc8inx 2584 3 two two CD cord-010092-uftc8inx 2584 4 related related JJ cord-010092-uftc8inx 2584 5 situations situation NNS cord-010092-uftc8inx 2584 6 with with IN cord-010092-uftc8inx 2584 7 unexplained unexplained JJ cord-010092-uftc8inx 2584 8 serological serological JJ cord-010092-uftc8inx 2584 9 reactivity reactivity NN cord-010092-uftc8inx 2584 10 . . . cord-010092-uftc8inx 2585 1 Firstly firstly RB cord-010092-uftc8inx 2585 2 , , , cord-010092-uftc8inx 2585 3 enzyme enzyme NN cord-010092-uftc8inx 2585 4 - - HYPH cord-010092-uftc8inx 2585 5 conversion conversion NN cord-010092-uftc8inx 2585 6 to to IN cord-010092-uftc8inx 2585 7 group group NN cord-010092-uftc8inx 2585 8 O o NN cord-010092-uftc8inx 2585 9 treatment treatment NN cord-010092-uftc8inx 2585 10 of of IN cord-010092-uftc8inx 2585 11 group group NN cord-010092-uftc8inx 2585 12 B B NNP cord-010092-uftc8inx 2585 13 ( ( -LRB- cord-010092-uftc8inx 2585 14 B B NNP cord-010092-uftc8inx 2585 15 - - HYPH cord-010092-uftc8inx 2585 16 ECO eco NN cord-010092-uftc8inx 2585 17 ) ) -RRB- cord-010092-uftc8inx 2585 18 red red JJ cord-010092-uftc8inx 2585 19 blood blood NN cord-010092-uftc8inx 2585 20 cells cell NNS cord-010092-uftc8inx 2585 21 ( ( -LRB- cord-010092-uftc8inx 2585 22 RBCs rbc NNS cord-010092-uftc8inx 2585 23 ) ) -RRB- cord-010092-uftc8inx 2585 24 with with IN cord-010092-uftc8inx 2585 25 a3-specific a3-specific NNS cord-010092-uftc8inx 2585 26 GH110 gh110 POS cord-010092-uftc8inx 2585 27 family family NN cord-010092-uftc8inx 2585 28 exogalactosidase exogalactosidase NN cord-010092-uftc8inx 2585 29 ( ( -LRB- cord-010092-uftc8inx 2585 30 Bzyme Bzyme NNP cord-010092-uftc8inx 2585 31 ) ) -RRB- cord-010092-uftc8inx 2585 32 abolishes abolish VBZ cord-010092-uftc8inx 2585 33 B b NN cord-010092-uftc8inx 2585 34 antigens antigen NNS cord-010092-uftc8inx 2585 35 as as IN cord-010092-uftc8inx 2585 36 detected detect VBN cord-010092-uftc8inx 2585 37 by by IN cord-010092-uftc8inx 2585 38 hemagglutination hemagglutination NN cord-010092-uftc8inx 2585 39 and and CC cord-010092-uftc8inx 2585 40 flow flow VB cord-010092-uftc8inx 2585 41 cytometry cytometry NN cord-010092-uftc8inx 2585 42 with with IN cord-010092-uftc8inx 2585 43 all all DT cord-010092-uftc8inx 2585 44 monoclonal monoclonal JJ cord-010092-uftc8inx 2585 45 anti anti NN cord-010092-uftc8inx 2585 46 - - NN cord-010092-uftc8inx 2585 47 B B NNP cord-010092-uftc8inx 2585 48 tested test VBN cord-010092-uftc8inx 2585 49 . . . cord-010092-uftc8inx 2586 1 Despite despite IN cord-010092-uftc8inx 2586 2 this this DT cord-010092-uftc8inx 2586 3 , , , cord-010092-uftc8inx 2586 4 40 40 CD cord-010092-uftc8inx 2586 5 % % NN cord-010092-uftc8inx 2586 6 of of IN cord-010092-uftc8inx 2586 7 group group NN cord-010092-uftc8inx 2586 8 O o NN cord-010092-uftc8inx 2586 9 plasmas plasma NNS cord-010092-uftc8inx 2586 10 have have VBP cord-010092-uftc8inx 2586 11 been be VBN cord-010092-uftc8inx 2586 12 reported report VBN cord-010092-uftc8inx 2586 13 to to TO cord-010092-uftc8inx 2586 14 give give VB cord-010092-uftc8inx 2586 15 positive positive JJ cord-010092-uftc8inx 2586 16 crossmatch crossmatch NN cord-010092-uftc8inx 2586 17 results result NNS cord-010092-uftc8inx 2586 18 with with IN cord-010092-uftc8inx 2586 19 B b NN cord-010092-uftc8inx 2586 20 - - HYPH cord-010092-uftc8inx 2586 21 ECO eco NN cord-010092-uftc8inx 2586 22 RBCs rbc NNS cord-010092-uftc8inx 2586 23 . . . cord-010092-uftc8inx 2587 1 Secondly secondly RB cord-010092-uftc8inx 2587 2 , , , cord-010092-uftc8inx 2587 3 plasmas plasma NNS cord-010092-uftc8inx 2587 4 from from IN cord-010092-uftc8inx 2587 5 AB AB NNP cord-010092-uftc8inx 2587 6 and and CC cord-010092-uftc8inx 2587 7 B B NNP cord-010092-uftc8inx 2587 8 individuals individual NNS cord-010092-uftc8inx 2587 9 of of IN cord-010092-uftc8inx 2587 10 the the DT cord-010092-uftc8inx 2587 11 globoside globoside NN cord-010092-uftc8inx 2587 12 - - HYPH cord-010092-uftc8inx 2587 13 deficient deficient JJ cord-010092-uftc8inx 2587 14 P p NN cord-010092-uftc8inx 2587 15 k k NN cord-010092-uftc8inx 2587 16 phenotype phenotype NN cord-010092-uftc8inx 2587 17 contain contain VBP cord-010092-uftc8inx 2587 18 anti anti JJ cord-010092-uftc8inx 2587 19 - - NN cord-010092-uftc8inx 2587 20 P p JJ cord-010092-uftc8inx 2587 21 and and CC cord-010092-uftc8inx 2587 22 anti anti JJ cord-010092-uftc8inx 2587 23 - - JJ cord-010092-uftc8inx 2587 24 PX2 px2 JJ cord-010092-uftc8inx 2587 25 but but CC cord-010092-uftc8inx 2587 26 react react VB cord-010092-uftc8inx 2587 27 stronger strong JJR cord-010092-uftc8inx 2587 28 with with IN cord-010092-uftc8inx 2587 29 Bpp Bpp NNP cord-010092-uftc8inx 2587 30 - - HYPH cord-010092-uftc8inx 2587 31 RBC RBC NNP cord-010092-uftc8inx 2587 32 than than IN cord-010092-uftc8inx 2587 33 with with IN cord-010092-uftc8inx 2587 34 App App NNP cord-010092-uftc8inx 2587 35 / / SYM cord-010092-uftc8inx 2587 36 Opp Opp NNP cord-010092-uftc8inx 2587 37 - - HYPH cord-010092-uftc8inx 2587 38 RBC RBC NNP cord-010092-uftc8inx 2587 39 . . . cord-010092-uftc8inx 2588 1 Based base VBN cord-010092-uftc8inx 2588 2 on on IN cord-010092-uftc8inx 2588 3 these these DT cord-010092-uftc8inx 2588 4 findings finding NNS cord-010092-uftc8inx 2588 5 , , , cord-010092-uftc8inx 2588 6 we -PRON- PRP cord-010092-uftc8inx 2588 7 hypothesized hypothesize VBD cord-010092-uftc8inx 2588 8 the the DT cord-010092-uftc8inx 2588 9 presence presence NN cord-010092-uftc8inx 2588 10 of of IN cord-010092-uftc8inx 2588 11 a a DT cord-010092-uftc8inx 2588 12 Bzyme Bzyme NNPS cord-010092-uftc8inx 2588 13 - - HYPH cord-010092-uftc8inx 2588 14 resistant resistant JJ cord-010092-uftc8inx 2588 15 , , , cord-010092-uftc8inx 2588 16 B b NN cord-010092-uftc8inx 2588 17 - - HYPH cord-010092-uftc8inx 2588 18 related relate VBN cord-010092-uftc8inx 2588 19 glycolipid glycolipid NN cord-010092-uftc8inx 2588 20 . . . cord-010092-uftc8inx 2589 1 Aims aim VBZ cord-010092-uftc8inx 2589 2 : : : cord-010092-uftc8inx 2589 3 To to TO cord-010092-uftc8inx 2589 4 identify identify VB cord-010092-uftc8inx 2589 5 the the DT cord-010092-uftc8inx 2589 6 molecular molecular JJ cord-010092-uftc8inx 2589 7 basis basis NN cord-010092-uftc8inx 2589 8 of of IN cord-010092-uftc8inx 2589 9 the the DT cord-010092-uftc8inx 2589 10 enigmatic enigmatic JJ cord-010092-uftc8inx 2589 11 serological serological JJ cord-010092-uftc8inx 2589 12 observations observation NNS cord-010092-uftc8inx 2589 13 outlined outline VBN cord-010092-uftc8inx 2589 14 above above RB cord-010092-uftc8inx 2589 15 . . . cord-010092-uftc8inx 2590 1 Methods method NNS cord-010092-uftc8inx 2590 2 : : : cord-010092-uftc8inx 2591 1 Plasma plasma NN cord-010092-uftc8inx 2591 2 and and CC cord-010092-uftc8inx 2591 3 eluates eluate NNS cord-010092-uftc8inx 2591 4 from from IN cord-010092-uftc8inx 2591 5 an an DT cord-010092-uftc8inx 2591 6 A A NNP cord-010092-uftc8inx 2591 7 1 1 CD cord-010092-uftc8inx 2591 8 B b NN cord-010092-uftc8inx 2591 9 individual individual NN cord-010092-uftc8inx 2591 10 with with IN cord-010092-uftc8inx 2591 11 the the DT cord-010092-uftc8inx 2591 12 P1 P1 NNP cord-010092-uftc8inx 2591 13 k k NNP cord-010092-uftc8inx 2591 14 phenotype phenotype NN cord-010092-uftc8inx 2591 15 were be VBD cord-010092-uftc8inx 2591 16 investigated investigate VBN cord-010092-uftc8inx 2591 17 by by IN cord-010092-uftc8inx 2591 18 hemagglutination hemagglutination NN cord-010092-uftc8inx 2591 19 and and CC cord-010092-uftc8inx 2591 20 flow flow NN cord-010092-uftc8inx 2591 21 cytometry cytometry NN cord-010092-uftc8inx 2591 22 , , , cord-010092-uftc8inx 2591 23 as as IN cord-010092-uftc8inx 2591 24 were be VBD cord-010092-uftc8inx 2591 25 eluates eluate NNS cord-010092-uftc8inx 2591 26 from from IN cord-010092-uftc8inx 2591 27 B B NNP cord-010092-uftc8inx 2591 28 P p NN cord-010092-uftc8inx 2591 29 1 1 CD cord-010092-uftc8inx 2591 30 k k NN cord-010092-uftc8inx 2591 31 and and CC cord-010092-uftc8inx 2591 32 O o UH cord-010092-uftc8inx 2591 33 plasma plasma NN cord-010092-uftc8inx 2591 34 . . . cord-010092-uftc8inx 2592 1 RBC RBC NNP cord-010092-uftc8inx 2592 2 membrane membrane NN cord-010092-uftc8inx 2592 3 glycolipids glycolipid NNS cord-010092-uftc8inx 2592 4 were be VBD cord-010092-uftc8inx 2592 5 extracted extract VBN cord-010092-uftc8inx 2592 6 from from IN cord-010092-uftc8inx 2592 7 two two CD cord-010092-uftc8inx 2592 8 batches batch NNS cord-010092-uftc8inx 2592 9 of of IN cord-010092-uftc8inx 2592 10 pooled pool VBN cord-010092-uftc8inx 2592 11 , , , cord-010092-uftc8inx 2592 12 expired expire VBD cord-010092-uftc8inx 2592 13 group group NN cord-010092-uftc8inx 2592 14 B B NNP cord-010092-uftc8inx 2592 15 - - HYPH cord-010092-uftc8inx 2592 16 RBC RBC NNP cord-010092-uftc8inx 2592 17 units unit NNS cord-010092-uftc8inx 2592 18 ( ( -LRB- cord-010092-uftc8inx 2592 19 frozen frozen JJ cord-010092-uftc8inx 2592 20 500-litre 500-litre CD cord-010092-uftc8inx 2592 21 reference reference NN cord-010092-uftc8inx 2592 22 preparation preparation NN cord-010092-uftc8inx 2592 23 and and CC cord-010092-uftc8inx 2592 24 confirmatory confirmatory JJ cord-010092-uftc8inx 2592 25 preparation preparation NN cord-010092-uftc8inx 2592 26 from from IN cord-010092-uftc8inx 2592 27 24 24 CD cord-010092-uftc8inx 2592 28 freshly freshly RB cord-010092-uftc8inx 2592 29 collected collect VBN cord-010092-uftc8inx 2592 30 units unit NNS cord-010092-uftc8inx 2592 31 ) ) -RRB- cord-010092-uftc8inx 2592 32 . . . cord-010092-uftc8inx 2593 1 Native native JJ cord-010092-uftc8inx 2593 2 or or CC cord-010092-uftc8inx 2593 3 enzyme enzyme RB cord-010092-uftc8inx 2593 4 - - HYPH cord-010092-uftc8inx 2593 5 treated treat VBN cord-010092-uftc8inx 2593 6 glycolipid glycolipid NNP cord-010092-uftc8inx 2593 7 fractions fraction NNS cord-010092-uftc8inx 2593 8 were be VBD cord-010092-uftc8inx 2593 9 analysed analyse VBN cord-010092-uftc8inx 2593 10 by by IN cord-010092-uftc8inx 2593 11 liquid liquid JJ cord-010092-uftc8inx 2593 12 chromatography chromatography NN cord-010092-uftc8inx 2593 13 electrospray electrospray JJ cord-010092-uftc8inx 2593 14 ionizationmass ionizationmass NNP cord-010092-uftc8inx 2593 15 spectrometry spectrometry NNP cord-010092-uftc8inx 2593 16 ( ( -LRB- cord-010092-uftc8inx 2593 17 LC LC NNP cord-010092-uftc8inx 2593 18 - - HYPH cord-010092-uftc8inx 2593 19 ESI ESI NNP cord-010092-uftc8inx 2593 20 / / SYM cord-010092-uftc8inx 2593 21 MS MS NNP cord-010092-uftc8inx 2593 22 ) ) -RRB- cord-010092-uftc8inx 2593 23 and and CC cord-010092-uftc8inx 2593 24 immunostaining immunostaining NN cord-010092-uftc8inx 2593 25 of of IN cord-010092-uftc8inx 2593 26 thin thin JJ cord-010092-uftc8inx 2593 27 layer layer NN cord-010092-uftc8inx 2593 28 chromatography chromatography NN cord-010092-uftc8inx 2593 29 ( ( -LRB- cord-010092-uftc8inx 2593 30 TLC TLC NNP cord-010092-uftc8inx 2593 31 ) ) -RRB- cord-010092-uftc8inx 2593 32 plates plate NNS cord-010092-uftc8inx 2593 33 . . . cord-010092-uftc8inx 2594 1 Antigen antigen NN cord-010092-uftc8inx 2594 2 expression expression NN cord-010092-uftc8inx 2594 3 in in IN cord-010092-uftc8inx 2594 4 the the DT cord-010092-uftc8inx 2594 5 H+BÀ H+BÀ NNP cord-010092-uftc8inx 2594 6 human human JJ cord-010092-uftc8inx 2594 7 erythroleukemia erythroleukemia NN cord-010092-uftc8inx 2594 8 ( ( -LRB- cord-010092-uftc8inx 2594 9 HEL HEL NNP cord-010092-uftc8inx 2594 10 ) ) -RRB- cord-010092-uftc8inx 2594 11 cell cell NN cord-010092-uftc8inx 2594 12 line line NN cord-010092-uftc8inx 2594 13 was be VBD cord-010092-uftc8inx 2594 14 analysed analyse VBN cord-010092-uftc8inx 2594 15 by by IN cord-010092-uftc8inx 2594 16 flow flow NN cord-010092-uftc8inx 2594 17 cytometry cytometry NN cord-010092-uftc8inx 2594 18 following follow VBG cord-010092-uftc8inx 2594 19 overexpression overexpression NN cord-010092-uftc8inx 2594 20 of of IN cord-010092-uftc8inx 2594 21 selected select VBN cord-010092-uftc8inx 2594 22 glycosyltransferases glycosyltransferase NNS cord-010092-uftc8inx 2594 23 . . . cord-010092-uftc8inx 2595 1 Results result NNS cord-010092-uftc8inx 2595 2 : : : cord-010092-uftc8inx 2596 1 Anti anti JJ cord-010092-uftc8inx 2596 2 - - NNP cord-010092-uftc8inx 2596 3 P p NN cord-010092-uftc8inx 2596 4 - - HYPH cord-010092-uftc8inx 2596 5 depleted deplete VBN cord-010092-uftc8inx 2596 6 eluates eluate NNS cord-010092-uftc8inx 2596 7 made make VBN cord-010092-uftc8inx 2596 8 from from IN cord-010092-uftc8inx 2596 9 A a DT cord-010092-uftc8inx 2596 10 1 1 CD cord-010092-uftc8inx 2596 11 B b NN cord-010092-uftc8inx 2596 12 P p NN cord-010092-uftc8inx 2596 13 1 1 CD cord-010092-uftc8inx 2596 14 k k NN cord-010092-uftc8inx 2596 15 plasma plasma NN cord-010092-uftc8inx 2596 16 contained contain VBD cord-010092-uftc8inx 2596 17 anti anti NNP cord-010092-uftc8inx 2596 18 - - JJ cord-010092-uftc8inx 2596 19 PX2 px2 JJ cord-010092-uftc8inx 2596 20 and and CC cord-010092-uftc8inx 2596 21 antibodies antibody NNS cord-010092-uftc8inx 2596 22 of of IN cord-010092-uftc8inx 2596 23 unknown unknown JJ cord-010092-uftc8inx 2596 24 specificity specificity NN cord-010092-uftc8inx 2596 25 that that WDT cord-010092-uftc8inx 2596 26 reacted react VBD cord-010092-uftc8inx 2596 27 stronger stronger RBR cord-010092-uftc8inx 2596 28 with with IN cord-010092-uftc8inx 2596 29 native native JJ cord-010092-uftc8inx 2596 30 or or CC cord-010092-uftc8inx 2596 31 papaintreated papaintreated JJ cord-010092-uftc8inx 2596 32 Bpp Bpp NNP cord-010092-uftc8inx 2596 33 - - HYPH cord-010092-uftc8inx 2596 34 RBCs rbc NNS cord-010092-uftc8inx 2596 35 compared compare VBN cord-010092-uftc8inx 2596 36 to to IN cord-010092-uftc8inx 2596 37 App App NNP cord-010092-uftc8inx 2596 38 / / SYM cord-010092-uftc8inx 2596 39 Opp opp NN cord-010092-uftc8inx 2596 40 - - HYPH cord-010092-uftc8inx 2596 41 RBCs rbc NNS cord-010092-uftc8inx 2596 42 . . . cord-010092-uftc8inx 2597 1 Anti Anti NNP cord-010092-uftc8inx 2597 2 - - NNP cord-010092-uftc8inx 2597 3 PX2 PX2 NNP cord-010092-uftc8inx 2597 4 was be VBD cord-010092-uftc8inx 2597 5 removed remove VBN cord-010092-uftc8inx 2597 6 by by IN cord-010092-uftc8inx 2597 7 adsorption adsorption NN cord-010092-uftc8inx 2597 8 onto onto IN cord-010092-uftc8inx 2597 9 Opp Opp NNP cord-010092-uftc8inx 2597 10 - - HYPH cord-010092-uftc8inx 2597 11 RBCs rbc NNS cord-010092-uftc8inx 2597 12 but but CC cord-010092-uftc8inx 2597 13 reactivity reactivity NN cord-010092-uftc8inx 2597 14 ( ( -LRB- cord-010092-uftc8inx 2597 15 here here RB cord-010092-uftc8inx 2597 16 designated designate VBN cord-010092-uftc8inx 2597 17 anti anti NNP cord-010092-uftc8inx 2597 18 - - NNP cord-010092-uftc8inx 2597 19 ExtB ExtB NNP cord-010092-uftc8inx 2597 20 ) ) -RRB- cord-010092-uftc8inx 2597 21 remained remain VBD cord-010092-uftc8inx 2597 22 against against IN cord-010092-uftc8inx 2597 23 B B NNP cord-010092-uftc8inx 2597 24 / / SYM cord-010092-uftc8inx 2597 25 Bpp Bpp NNP cord-010092-uftc8inx 2597 26 / / SYM cord-010092-uftc8inx 2597 27 B B NNP cord-010092-uftc8inx 2597 28 - - HYPH cord-010092-uftc8inx 2597 29 ECO eco NN cord-010092-uftc8inx 2597 30 RBCs rbc NNS cord-010092-uftc8inx 2597 31 . . . cord-010092-uftc8inx 2598 1 LC LC NNP cord-010092-uftc8inx 2598 2 - - HYPH cord-010092-uftc8inx 2598 3 ESI ESI NNP cord-010092-uftc8inx 2598 4 / / SYM cord-010092-uftc8inx 2598 5 MS MS NNP cord-010092-uftc8inx 2598 6 of of IN cord-010092-uftc8inx 2598 7 glycolipid glycolipid NNP cord-010092-uftc8inx 2598 8 fractions fraction NNS cord-010092-uftc8inx 2598 9 from from IN cord-010092-uftc8inx 2598 10 group group NN cord-010092-uftc8inx 2598 11 B B NNP cord-010092-uftc8inx 2598 12 units unit NNS cord-010092-uftc8inx 2598 13 revealed reveal VBD cord-010092-uftc8inx 2598 14 an an DT cord-010092-uftc8inx 2598 15 unknown unknown JJ cord-010092-uftc8inx 2598 16 HexNAc hexnac NN cord-010092-uftc8inx 2598 17 - - HYPH cord-010092-uftc8inx 2598 18 Hex-(Fuc-)Hex-4HexNAc hex-(fuc-)hex-4hexnac NN cord-010092-uftc8inx 2598 19 - - HYPH cord-010092-uftc8inx 2598 20 Hex-4Hex hex-4hex NN cord-010092-uftc8inx 2598 21 heptasaccharide heptasaccharide NN cord-010092-uftc8inx 2598 22 . . . cord-010092-uftc8inx 2599 1 Upon upon IN cord-010092-uftc8inx 2599 2 b b LS cord-010092-uftc8inx 2599 3 - - : cord-010092-uftc8inx 2599 4 Nacetylhexosaminidase Nacetylhexosaminidase NNP cord-010092-uftc8inx 2599 5 treatment treatment NN cord-010092-uftc8inx 2599 6 of of IN cord-010092-uftc8inx 2599 7 this this DT cord-010092-uftc8inx 2599 8 candidate candidate NN cord-010092-uftc8inx 2599 9 structure structure NN cord-010092-uftc8inx 2599 10 , , , cord-010092-uftc8inx 2599 11 a a DT cord-010092-uftc8inx 2599 12 group group NN cord-010092-uftc8inx 2599 13 B b NN cord-010092-uftc8inx 2599 14 type type NN cord-010092-uftc8inx 2599 15 2 2 CD cord-010092-uftc8inx 2599 16 hexasaccharide hexasaccharide NN cord-010092-uftc8inx 2599 17 was be VBD cord-010092-uftc8inx 2599 18 produced produce VBN cord-010092-uftc8inx 2599 19 , , , cord-010092-uftc8inx 2599 20 demonstrating demonstrate VBG cord-010092-uftc8inx 2599 21 that that IN cord-010092-uftc8inx 2599 22 the the DT cord-010092-uftc8inx 2599 23 terminal terminal NN cord-010092-uftc8inx 2599 24 HexNAc HexNAc NNP cord-010092-uftc8inx 2599 25 of of IN cord-010092-uftc8inx 2599 26 the the DT cord-010092-uftc8inx 2599 27 HexNAc HexNAc NNP cord-010092-uftc8inx 2599 28 - - HYPH cord-010092-uftc8inx 2599 29 Gala3(Fuca2)Galb4GlcNAcb3Galb4Glc Gala3(Fuca2)Galb4GlcNAcb3Galb4Glc NNP cord-010092-uftc8inx 2599 30 heptasaccharide heptasaccharide NN cord-010092-uftc8inx 2599 31 was be VBD cord-010092-uftc8inx 2599 32 b b NN cord-010092-uftc8inx 2599 33 - - HYPH cord-010092-uftc8inx 2599 34 linked link VBN cord-010092-uftc8inx 2599 35 . . . cord-010092-uftc8inx 2600 1 Since since IN cord-010092-uftc8inx 2600 2 the the DT cord-010092-uftc8inx 2600 3 discovery discovery NN cord-010092-uftc8inx 2600 4 of of IN cord-010092-uftc8inx 2600 5 the the DT cord-010092-uftc8inx 2600 6 anti anti JJ cord-010092-uftc8inx 2600 7 - - JJ cord-010092-uftc8inx 2600 8 platelet platelet JJ cord-010092-uftc8inx 2600 9 effects effect NNS cord-010092-uftc8inx 2600 10 of of IN cord-010092-uftc8inx 2600 11 aspirin aspirin NN cord-010092-uftc8inx 2600 12 platelets platelet NNS cord-010092-uftc8inx 2600 13 have have VBP cord-010092-uftc8inx 2600 14 been be VBN cord-010092-uftc8inx 2600 15 a a DT cord-010092-uftc8inx 2600 16 major major JJ cord-010092-uftc8inx 2600 17 therapeutic therapeutic JJ cord-010092-uftc8inx 2600 18 target target NN cord-010092-uftc8inx 2600 19 for for IN cord-010092-uftc8inx 2600 20 pharmaceutical pharmaceutical JJ cord-010092-uftc8inx 2600 21 companies company NNS cord-010092-uftc8inx 2600 22 and and CC cord-010092-uftc8inx 2600 23 also also RB cord-010092-uftc8inx 2600 24 a a DT cord-010092-uftc8inx 2600 25 very very RB cord-010092-uftc8inx 2600 26 profitable profitable JJ cord-010092-uftc8inx 2600 27 target target NN cord-010092-uftc8inx 2600 28 . . . cord-010092-uftc8inx 2601 1 However however RB cord-010092-uftc8inx 2601 2 , , , cord-010092-uftc8inx 2601 3 the the DT cord-010092-uftc8inx 2601 4 effectiveness effectiveness NN cord-010092-uftc8inx 2601 5 of of IN cord-010092-uftc8inx 2601 6 aspirin aspirin NN cord-010092-uftc8inx 2601 7 has have VBZ cord-010092-uftc8inx 2601 8 also also RB cord-010092-uftc8inx 2601 9 been be VBN cord-010092-uftc8inx 2601 10 a a DT cord-010092-uftc8inx 2601 11 challenge challenge NN cord-010092-uftc8inx 2601 12 as as IN cord-010092-uftc8inx 2601 13 it -PRON- PRP cord-010092-uftc8inx 2601 14 is be VBZ cord-010092-uftc8inx 2601 15 an an DT cord-010092-uftc8inx 2601 16 inexpensive inexpensive JJ cord-010092-uftc8inx 2601 17 drug drug NN cord-010092-uftc8inx 2601 18 and and CC cord-010092-uftc8inx 2601 19 any any DT cord-010092-uftc8inx 2601 20 new new JJ cord-010092-uftc8inx 2601 21 agent agent NN cord-010092-uftc8inx 2601 22 needs need VBZ cord-010092-uftc8inx 2601 23 to to TO cord-010092-uftc8inx 2601 24 show show VB cord-010092-uftc8inx 2601 25 clear clear JJ cord-010092-uftc8inx 2601 26 benefit benefit NN cord-010092-uftc8inx 2601 27 over over IN cord-010092-uftc8inx 2601 28 aspirin aspirin NN cord-010092-uftc8inx 2601 29 . . . cord-010092-uftc8inx 2602 1 Furthermore furthermore RB cord-010092-uftc8inx 2602 2 the the DT cord-010092-uftc8inx 2602 3 risk risk NN cord-010092-uftc8inx 2602 4 of of IN cord-010092-uftc8inx 2602 5 bleeding bleed VBG cord-010092-uftc8inx 2602 6 from from IN cord-010092-uftc8inx 2602 7 anti anti JJ cord-010092-uftc8inx 2602 8 - - JJ cord-010092-uftc8inx 2602 9 platelet platelet JJ cord-010092-uftc8inx 2602 10 agents agent NNS cord-010092-uftc8inx 2602 11 , , , cord-010092-uftc8inx 2602 12 especially especially RB cord-010092-uftc8inx 2602 13 cerebral cerebral JJ cord-010092-uftc8inx 2602 14 bleeds bleed NNS cord-010092-uftc8inx 2602 15 , , , cord-010092-uftc8inx 2602 16 has have VBZ cord-010092-uftc8inx 2602 17 also also RB cord-010092-uftc8inx 2602 18 presented present VBN cord-010092-uftc8inx 2602 19 challenges challenge NNS cord-010092-uftc8inx 2602 20 . . . cord-010092-uftc8inx 2603 1 In in IN cord-010092-uftc8inx 2603 2 the the DT cord-010092-uftc8inx 2603 3 1990 1990 CD cord-010092-uftc8inx 2603 4 's 's POS cord-010092-uftc8inx 2603 5 orally orally RB cord-010092-uftc8inx 2603 6 active active JJ cord-010092-uftc8inx 2603 7 GPIIb GPIIb NNS cord-010092-uftc8inx 2603 8 / / SYM cord-010092-uftc8inx 2603 9 IIIa iiia NN cord-010092-uftc8inx 2603 10 antagonists antagonist NNS cord-010092-uftc8inx 2603 11 were be VBD cord-010092-uftc8inx 2603 12 considered consider VBN cord-010092-uftc8inx 2603 13 to to TO cord-010092-uftc8inx 2603 14 be be VB cord-010092-uftc8inx 2603 15 the the DT cord-010092-uftc8inx 2603 16 ' ' `` cord-010092-uftc8inx 2603 17 super super NNP cord-010092-uftc8inx 2603 18 aspirin aspirin NN cord-010092-uftc8inx 2603 19 ' ' '' cord-010092-uftc8inx 2603 20 but but CC cord-010092-uftc8inx 2603 21 clinical clinical JJ cord-010092-uftc8inx 2603 22 trials trial NNS cord-010092-uftc8inx 2603 23 showed show VBD cord-010092-uftc8inx 2603 24 increased increase VBN cord-010092-uftc8inx 2603 25 mortality mortality NN cord-010092-uftc8inx 2603 26 and and CC cord-010092-uftc8inx 2603 27 ultimately ultimately RB cord-010092-uftc8inx 2603 28 this this DT cord-010092-uftc8inx 2603 29 class class NN cord-010092-uftc8inx 2603 30 of of IN cord-010092-uftc8inx 2603 31 drugs drug NNS cord-010092-uftc8inx 2603 32 was be VBD cord-010092-uftc8inx 2603 33 relegated relegate VBN cord-010092-uftc8inx 2603 34 to to IN cord-010092-uftc8inx 2603 35 iv iv LS cord-010092-uftc8inx 2603 36 use use VB cord-010092-uftc8inx 2603 37 only only RB cord-010092-uftc8inx 2603 38 in in IN cord-010092-uftc8inx 2603 39 high high JJ cord-010092-uftc8inx 2603 40 - - HYPH cord-010092-uftc8inx 2603 41 risk risk NN cord-010092-uftc8inx 2603 42 patients patient NNS cord-010092-uftc8inx 2603 43 . . . cord-010092-uftc8inx 2604 1 GPIb GPIb NNP cord-010092-uftc8inx 2604 2 / / SYM cord-010092-uftc8inx 2604 3 IX IX NNP cord-010092-uftc8inx 2604 4 / / SYM cord-010092-uftc8inx 2604 5 V V NNP cord-010092-uftc8inx 2604 6 antagonists antagonist NNS cord-010092-uftc8inx 2604 7 were be VBD cord-010092-uftc8inx 2604 8 also also RB cord-010092-uftc8inx 2604 9 a a DT cord-010092-uftc8inx 2604 10 promising promising JJ cord-010092-uftc8inx 2604 11 drug drug NN cord-010092-uftc8inx 2604 12 target target NN cord-010092-uftc8inx 2604 13 but but CC cord-010092-uftc8inx 2604 14 no no DT cord-010092-uftc8inx 2604 15 agent agent NN cord-010092-uftc8inx 2604 16 made make VBD cord-010092-uftc8inx 2604 17 it -PRON- PRP cord-010092-uftc8inx 2604 18 to to IN cord-010092-uftc8inx 2604 19 market market VB cord-010092-uftc8inx 2604 20 . . . cord-010092-uftc8inx 2605 1 The the DT cord-010092-uftc8inx 2605 2 real real JJ cord-010092-uftc8inx 2605 3 breakthrough breakthrough NN cord-010092-uftc8inx 2605 4 was be VBD cord-010092-uftc8inx 2605 5 the the DT cord-010092-uftc8inx 2605 6 discovery discovery NN cord-010092-uftc8inx 2605 7 of of IN cord-010092-uftc8inx 2605 8 the the DT cord-010092-uftc8inx 2605 9 P2Y12 P2Y12 NNP cord-010092-uftc8inx 2605 10 antagonist antagonist NN cord-010092-uftc8inx 2605 11 clopidogrel clopidogrel NNP cord-010092-uftc8inx 2605 12 which which WDT cord-010092-uftc8inx 2605 13 , , , cord-010092-uftc8inx 2605 14 in in IN cord-010092-uftc8inx 2605 15 conjunction conjunction NN cord-010092-uftc8inx 2605 16 with with IN cord-010092-uftc8inx 2605 17 aspirin aspirin NN cord-010092-uftc8inx 2605 18 , , , cord-010092-uftc8inx 2605 19 proved prove VBD cord-010092-uftc8inx 2605 20 to to TO cord-010092-uftc8inx 2605 21 be be VB cord-010092-uftc8inx 2605 22 very very RB cord-010092-uftc8inx 2605 23 effective effective JJ cord-010092-uftc8inx 2605 24 at at IN cord-010092-uftc8inx 2605 25 preventing prevent VBG cord-010092-uftc8inx 2605 26 thrombotic thrombotic JJ cord-010092-uftc8inx 2605 27 events event NNS cord-010092-uftc8inx 2605 28 and and CC cord-010092-uftc8inx 2605 29 as as IN cord-010092-uftc8inx 2605 30 a a DT cord-010092-uftc8inx 2605 31 result result NN cord-010092-uftc8inx 2605 32 it -PRON- PRP cord-010092-uftc8inx 2605 33 became become VBD cord-010092-uftc8inx 2605 34 the the DT cord-010092-uftc8inx 2605 35 biggest big JJS cord-010092-uftc8inx 2605 36 selling selling NN cord-010092-uftc8inx 2605 37 drug drug NN cord-010092-uftc8inx 2605 38 in in IN cord-010092-uftc8inx 2605 39 the the DT cord-010092-uftc8inx 2605 40 world world NN cord-010092-uftc8inx 2605 41 at at IN cord-010092-uftc8inx 2605 42 the the DT cord-010092-uftc8inx 2605 43 time time NN cord-010092-uftc8inx 2605 44 . . . cord-010092-uftc8inx 2606 1 With with IN cord-010092-uftc8inx 2606 2 clopidogrel clopidogrel NNP cord-010092-uftc8inx 2606 3 now now RB cord-010092-uftc8inx 2606 4 offpatent offpatent VBD cord-010092-uftc8inx 2606 5 the the DT cord-010092-uftc8inx 2606 6 combination combination NN cord-010092-uftc8inx 2606 7 of of IN cord-010092-uftc8inx 2606 8 aspirin aspirin NN cord-010092-uftc8inx 2606 9 and and CC cord-010092-uftc8inx 2606 10 clopidogrel clopidogrel NN cord-010092-uftc8inx 2606 11 is be VBZ cord-010092-uftc8inx 2606 12 a a DT cord-010092-uftc8inx 2606 13 formidable formidable JJ cord-010092-uftc8inx 2606 14 challenge challenge NN cord-010092-uftc8inx 2606 15 to to IN cord-010092-uftc8inx 2606 16 any any DT cord-010092-uftc8inx 2606 17 new new JJ cord-010092-uftc8inx 2606 18 agent agent NN cord-010092-uftc8inx 2606 19 both both CC cord-010092-uftc8inx 2606 20 in in IN cord-010092-uftc8inx 2606 21 efficacy efficacy NN cord-010092-uftc8inx 2606 22 terms term NNS cord-010092-uftc8inx 2606 23 and and CC cord-010092-uftc8inx 2606 24 pharmacoeonomic pharmacoeonomic JJ cord-010092-uftc8inx 2606 25 terms term NNS cord-010092-uftc8inx 2606 26 . . . cord-010092-uftc8inx 2607 1 So so RB cord-010092-uftc8inx 2607 2 is be VBZ cord-010092-uftc8inx 2607 3 there there EX cord-010092-uftc8inx 2607 4 a a DT cord-010092-uftc8inx 2607 5 future future NN cord-010092-uftc8inx 2607 6 for for IN cord-010092-uftc8inx 2607 7 new new JJ cord-010092-uftc8inx 2607 8 anti anti JJ cord-010092-uftc8inx 2607 9 - - JJ cord-010092-uftc8inx 2607 10 platelet platelet JJ cord-010092-uftc8inx 2607 11 agents agent NNS cord-010092-uftc8inx 2607 12 ? ? . cord-010092-uftc8inx 2608 1 With with IN cord-010092-uftc8inx 2608 2 the the DT cord-010092-uftc8inx 2608 3 growing grow VBG cord-010092-uftc8inx 2608 4 awareness awareness NN cord-010092-uftc8inx 2608 5 of of IN cord-010092-uftc8inx 2608 6 the the DT cord-010092-uftc8inx 2608 7 role role NN cord-010092-uftc8inx 2608 8 of of IN cord-010092-uftc8inx 2608 9 platelets platelet NNS cord-010092-uftc8inx 2608 10 in in IN cord-010092-uftc8inx 2608 11 inflammation inflammation NN cord-010092-uftc8inx 2608 12 and and CC cord-010092-uftc8inx 2608 13 an an DT cord-010092-uftc8inx 2608 14 understanding understanding NN cord-010092-uftc8inx 2608 15 of of IN cord-010092-uftc8inx 2608 16 how how WRB cord-010092-uftc8inx 2608 17 the the DT cord-010092-uftc8inx 2608 18 immune immune JJ cord-010092-uftc8inx 2608 19 activation activation NN cord-010092-uftc8inx 2608 20 of of IN cord-010092-uftc8inx 2608 21 platelets platelet NNS cord-010092-uftc8inx 2608 22 differs differ VBZ cord-010092-uftc8inx 2608 23 from from IN cord-010092-uftc8inx 2608 24 the the DT cord-010092-uftc8inx 2608 25 classical classical JJ cord-010092-uftc8inx 2608 26 haemostatic haemostatic JJ cord-010092-uftc8inx 2608 27 activation activation NN cord-010092-uftc8inx 2608 28 of of IN cord-010092-uftc8inx 2608 29 platelets platelet NNS cord-010092-uftc8inx 2608 30 it -PRON- PRP cord-010092-uftc8inx 2608 31 is be VBZ cord-010092-uftc8inx 2608 32 now now RB cord-010092-uftc8inx 2608 33 possible possible JJ cord-010092-uftc8inx 2608 34 to to TO cord-010092-uftc8inx 2608 35 develop develop VB cord-010092-uftc8inx 2608 36 novel novel JJ cord-010092-uftc8inx 2608 37 anti anti JJ cord-010092-uftc8inx 2608 38 - - JJ cord-010092-uftc8inx 2608 39 platelet platelet JJ cord-010092-uftc8inx 2608 40 agents agent NNS cord-010092-uftc8inx 2608 41 that that WDT cord-010092-uftc8inx 2608 42 target target VBP cord-010092-uftc8inx 2608 43 inflammation inflammation NN cord-010092-uftc8inx 2608 44 without without IN cord-010092-uftc8inx 2608 45 compromising compromise VBG cord-010092-uftc8inx 2608 46 haemostasis haemostasis NN cord-010092-uftc8inx 2608 47 . . . cord-010092-uftc8inx 2609 1 It -PRON- PRP cord-010092-uftc8inx 2609 2 is be VBZ cord-010092-uftc8inx 2609 3 here here RB cord-010092-uftc8inx 2609 4 that that IN cord-010092-uftc8inx 2609 5 we -PRON- PRP cord-010092-uftc8inx 2609 6 should should MD cord-010092-uftc8inx 2609 7 look look VB cord-010092-uftc8inx 2609 8 for for IN cord-010092-uftc8inx 2609 9 the the DT cord-010092-uftc8inx 2609 10 next next JJ cord-010092-uftc8inx 2609 11 generation generation NN cord-010092-uftc8inx 2609 12 of of IN cord-010092-uftc8inx 2609 13 anti anti JJ cord-010092-uftc8inx 2609 14 - - JJ cord-010092-uftc8inx 2609 15 platelet platelet JJ cord-010092-uftc8inx 2609 16 agent agent NN cord-010092-uftc8inx 2609 17 . . . cord-010092-uftc8inx 2610 1 4C 4c LS cord-010092-uftc8inx 2610 2 - - : cord-010092-uftc8inx 2610 3 S21 S21 NNP cord-010092-uftc8inx 2610 4 - - HYPH cord-010092-uftc8inx 2610 5 02 02 CD cord-010092-uftc8inx 2610 6 University University NNP cord-010092-uftc8inx 2610 7 Hospitals Hospitals NNPS cord-010092-uftc8inx 2610 8 of of IN cord-010092-uftc8inx 2610 9 Geneva Geneva NNP cord-010092-uftc8inx 2610 10 , , , cord-010092-uftc8inx 2610 11 Geneva Geneva NNP cord-010092-uftc8inx 2610 12 , , , cord-010092-uftc8inx 2610 13 Switzerland Switzerland NNP cord-010092-uftc8inx 2610 14 Platelet platelet NN cord-010092-uftc8inx 2610 15 function function NN cord-010092-uftc8inx 2610 16 defects defect NNS cord-010092-uftc8inx 2610 17 , , , cord-010092-uftc8inx 2610 18 either either CC cord-010092-uftc8inx 2610 19 congenital congenital JJ cord-010092-uftc8inx 2610 20 or or CC cord-010092-uftc8inx 2610 21 acquired acquire VBN cord-010092-uftc8inx 2610 22 , , , cord-010092-uftc8inx 2610 23 are be VBP cord-010092-uftc8inx 2610 24 associated associate VBN cord-010092-uftc8inx 2610 25 with with IN cord-010092-uftc8inx 2610 26 increased increase VBN cord-010092-uftc8inx 2610 27 bleeding bleed VBG cord-010092-uftc8inx 2610 28 risk risk NN cord-010092-uftc8inx 2610 29 , , , cord-010092-uftc8inx 2610 30 particularly particularly RB cord-010092-uftc8inx 2610 31 in in IN cord-010092-uftc8inx 2610 32 a a DT cord-010092-uftc8inx 2610 33 perioperative perioperative JJ cord-010092-uftc8inx 2610 34 setting setting NN cord-010092-uftc8inx 2610 35 . . . cord-010092-uftc8inx 2611 1 The the DT cord-010092-uftc8inx 2611 2 use use NN cord-010092-uftc8inx 2611 3 of of IN cord-010092-uftc8inx 2611 4 platelet platelet NN cord-010092-uftc8inx 2611 5 function function NN cord-010092-uftc8inx 2611 6 assays assay NNS cord-010092-uftc8inx 2611 7 is be VBZ cord-010092-uftc8inx 2611 8 therefore therefore RB cord-010092-uftc8inx 2611 9 tempting tempt VBG cord-010092-uftc8inx 2611 10 in in IN cord-010092-uftc8inx 2611 11 order order NN cord-010092-uftc8inx 2611 12 to to TO cord-010092-uftc8inx 2611 13 tailor tailor VB cord-010092-uftc8inx 2611 14 transfusion transfusion NN cord-010092-uftc8inx 2611 15 and and CC cord-010092-uftc8inx 2611 16 limit limit VB cord-010092-uftc8inx 2611 17 platelet platelet NN cord-010092-uftc8inx 2611 18 transfusion transfusion NN cord-010092-uftc8inx 2611 19 to to IN cord-010092-uftc8inx 2611 20 those those DT cord-010092-uftc8inx 2611 21 bleeding bleed VBG cord-010092-uftc8inx 2611 22 patients patient NNS cord-010092-uftc8inx 2611 23 with with IN cord-010092-uftc8inx 2611 24 impaired impaired JJ cord-010092-uftc8inx 2611 25 platelet platelet NN cord-010092-uftc8inx 2611 26 function function NN cord-010092-uftc8inx 2611 27 , , , cord-010092-uftc8inx 2611 28 as as IN cord-010092-uftc8inx 2611 29 assessed assess VBN cord-010092-uftc8inx 2611 30 by by IN cord-010092-uftc8inx 2611 31 those those DT cord-010092-uftc8inx 2611 32 assays assay NNS cord-010092-uftc8inx 2611 33 . . . cord-010092-uftc8inx 2612 1 However however RB cord-010092-uftc8inx 2612 2 , , , cord-010092-uftc8inx 2612 3 the the DT cord-010092-uftc8inx 2612 4 current current JJ cord-010092-uftc8inx 2612 5 guidelines guideline NNS cord-010092-uftc8inx 2612 6 provide provide VBP cord-010092-uftc8inx 2612 7 only only JJ cord-010092-uftc8inx 2612 8 weak weak JJ cord-010092-uftc8inx 2612 9 recommendations recommendation NNS cord-010092-uftc8inx 2612 10 supporting support VBG cord-010092-uftc8inx 2612 11 the the DT cord-010092-uftc8inx 2612 12 routine routine JJ cord-010092-uftc8inx 2612 13 use use NN cord-010092-uftc8inx 2612 14 of of IN cord-010092-uftc8inx 2612 15 these these DT cord-010092-uftc8inx 2612 16 assays assay NNS cord-010092-uftc8inx 2612 17 . . . cord-010092-uftc8inx 2613 1 Indeed indeed RB cord-010092-uftc8inx 2613 2 , , , cord-010092-uftc8inx 2613 3 there there EX cord-010092-uftc8inx 2613 4 are be VBP cord-010092-uftc8inx 2613 5 numerous numerous JJ cord-010092-uftc8inx 2613 6 platelet platelet NN cord-010092-uftc8inx 2613 7 function function NN cord-010092-uftc8inx 2613 8 assays assay NNS cord-010092-uftc8inx 2613 9 on on IN cord-010092-uftc8inx 2613 10 the the DT cord-010092-uftc8inx 2613 11 market market NN cord-010092-uftc8inx 2613 12 that that WDT cord-010092-uftc8inx 2613 13 differ differ VBP cord-010092-uftc8inx 2613 14 in in IN cord-010092-uftc8inx 2613 15 their -PRON- PRP$ cord-010092-uftc8inx 2613 16 method method NN cord-010092-uftc8inx 2613 17 of of IN cord-010092-uftc8inx 2613 18 evaluation evaluation NN cord-010092-uftc8inx 2613 19 of of IN cord-010092-uftc8inx 2613 20 platelet platelet NN cord-010092-uftc8inx 2613 21 function function NN cord-010092-uftc8inx 2613 22 and and CC cord-010092-uftc8inx 2613 23 agreement agreement NN cord-010092-uftc8inx 2613 24 between between IN cord-010092-uftc8inx 2613 25 their -PRON- PRP$ cord-010092-uftc8inx 2613 26 results result NNS cord-010092-uftc8inx 2613 27 is be VBZ cord-010092-uftc8inx 2613 28 at at IN cord-010092-uftc8inx 2613 29 best good JJS cord-010092-uftc8inx 2613 30 moderate moderate JJ cord-010092-uftc8inx 2613 31 . . . cord-010092-uftc8inx 2614 1 The the DT cord-010092-uftc8inx 2614 2 threshold threshold NN cord-010092-uftc8inx 2614 3 values value NNS cord-010092-uftc8inx 2614 4 beyond beyond IN cord-010092-uftc8inx 2614 5 which which WDT cord-010092-uftc8inx 2614 6 procedure procedure NN cord-010092-uftc8inx 2614 7 - - HYPH cord-010092-uftc8inx 2614 8 associated associate VBN cord-010092-uftc8inx 2614 9 bleeding bleed VBG cord-010092-uftc8inx 2614 10 risk risk NN cord-010092-uftc8inx 2614 11 becomes become VBZ cord-010092-uftc8inx 2614 12 worrisome worrisome JJ cord-010092-uftc8inx 2614 13 is be VBZ cord-010092-uftc8inx 2614 14 not not RB cord-010092-uftc8inx 2614 15 standardized standardize VBN cord-010092-uftc8inx 2614 16 . . . cord-010092-uftc8inx 2615 1 Moreover moreover RB cord-010092-uftc8inx 2615 2 , , , cord-010092-uftc8inx 2615 3 observational observational JJ cord-010092-uftc8inx 2615 4 studies study NNS cord-010092-uftc8inx 2615 5 addressing address VBG cord-010092-uftc8inx 2615 6 the the DT cord-010092-uftc8inx 2615 7 predictive predictive JJ cord-010092-uftc8inx 2615 8 value value NN cord-010092-uftc8inx 2615 9 of of IN cord-010092-uftc8inx 2615 10 platelet platelet NN cord-010092-uftc8inx 2615 11 function function NN cord-010092-uftc8inx 2615 12 testing testing NN cord-010092-uftc8inx 2615 13 in in IN cord-010092-uftc8inx 2615 14 perioperative perioperative JJ cord-010092-uftc8inx 2615 15 or or CC cord-010092-uftc8inx 2615 16 spontaneous spontaneous JJ cord-010092-uftc8inx 2615 17 bleeding bleeding NN cord-010092-uftc8inx 2615 18 are be VBP cord-010092-uftc8inx 2615 19 not not RB cord-010092-uftc8inx 2615 20 consistent consistent JJ cord-010092-uftc8inx 2615 21 . . . cord-010092-uftc8inx 2616 1 Finally finally RB cord-010092-uftc8inx 2616 2 , , , cord-010092-uftc8inx 2616 3 management management NN cord-010092-uftc8inx 2616 4 trials trial NNS cord-010092-uftc8inx 2616 5 with with IN cord-010092-uftc8inx 2616 6 randomized randomized JJ cord-010092-uftc8inx 2616 7 patients patient NNS cord-010092-uftc8inx 2616 8 assessing assess VBG cord-010092-uftc8inx 2616 9 the the DT cord-010092-uftc8inx 2616 10 benefit benefit NN cord-010092-uftc8inx 2616 11 of of IN cord-010092-uftc8inx 2616 12 platelet platelet NN cord-010092-uftc8inx 2616 13 function function NN cord-010092-uftc8inx 2616 14 testing testing NN cord-010092-uftc8inx 2616 15 are be VBP cord-010092-uftc8inx 2616 16 scarce scarce JJ cord-010092-uftc8inx 2616 17 . . . cord-010092-uftc8inx 2617 1 More More JJR cord-010092-uftc8inx 2617 2 recent recent JJ cord-010092-uftc8inx 2617 3 data datum NNS cord-010092-uftc8inx 2617 4 identified identify VBD cord-010092-uftc8inx 2617 5 selected select VBN cord-010092-uftc8inx 2617 6 situations situation NNS cord-010092-uftc8inx 2617 7 where where WRB cord-010092-uftc8inx 2617 8 platelet platelet NN cord-010092-uftc8inx 2617 9 function function NN cord-010092-uftc8inx 2617 10 testing testing NN cord-010092-uftc8inx 2617 11 may may MD cord-010092-uftc8inx 2617 12 be be VB cord-010092-uftc8inx 2617 13 useful useful JJ cord-010092-uftc8inx 2617 14 though though RB cord-010092-uftc8inx 2617 15 . . . cord-010092-uftc8inx 2618 1 I -PRON- PRP cord-010092-uftc8inx 2618 2 will will MD cord-010092-uftc8inx 2618 3 review review VB cord-010092-uftc8inx 2618 4 the the DT cord-010092-uftc8inx 2618 5 different different JJ cord-010092-uftc8inx 2618 6 platelet platelet NN cord-010092-uftc8inx 2618 7 function function NN cord-010092-uftc8inx 2618 8 assays assay NNS cord-010092-uftc8inx 2618 9 as as RB cord-010092-uftc8inx 2618 10 well well RB cord-010092-uftc8inx 2618 11 as as IN cord-010092-uftc8inx 2618 12 selected select VBN cord-010092-uftc8inx 2618 13 clinical clinical JJ cord-010092-uftc8inx 2618 14 studies study NNS cord-010092-uftc8inx 2618 15 addressing address VBG cord-010092-uftc8inx 2618 16 the the DT cord-010092-uftc8inx 2618 17 impact impact NN cord-010092-uftc8inx 2618 18 of of IN cord-010092-uftc8inx 2618 19 platelet platelet NN cord-010092-uftc8inx 2618 20 function function NN cord-010092-uftc8inx 2618 21 testing test VBG cord-010092-uftc8inx 2618 22 to to TO cord-010092-uftc8inx 2618 23 improve improve VB cord-010092-uftc8inx 2618 24 bleeding bleeding NN cord-010092-uftc8inx 2618 25 and and CC cord-010092-uftc8inx 2618 26 transfusion transfusion NN cord-010092-uftc8inx 2618 27 - - HYPH cord-010092-uftc8inx 2618 28 related relate VBN cord-010092-uftc8inx 2618 29 outcomes outcome NNS cord-010092-uftc8inx 2618 30 . . . cord-010092-uftc8inx 2619 1 The the DT cord-010092-uftc8inx 2619 2 latest late JJS cord-010092-uftc8inx 2619 3 recommendation recommendation NN cord-010092-uftc8inx 2619 4 will will MD cord-010092-uftc8inx 2619 5 be be VB cord-010092-uftc8inx 2619 6 addressed address VBN cord-010092-uftc8inx 2619 7 too too RB cord-010092-uftc8inx 2619 8 . . . cord-010092-uftc8inx 2620 1 Background background NN cord-010092-uftc8inx 2620 2 : : : cord-010092-uftc8inx 2621 1 Platelet platelet NN cord-010092-uftc8inx 2621 2 refractoriness refractoriness NN cord-010092-uftc8inx 2621 3 complicates complicate VBZ cord-010092-uftc8inx 2621 4 the the DT cord-010092-uftc8inx 2621 5 provision provision NN cord-010092-uftc8inx 2621 6 of of IN cord-010092-uftc8inx 2621 7 platelet platelet NN cord-010092-uftc8inx 2621 8 transfusions transfusion NNS cord-010092-uftc8inx 2621 9 in in IN cord-010092-uftc8inx 2621 10 management management NN cord-010092-uftc8inx 2621 11 of of IN cord-010092-uftc8inx 2621 12 thrombocytopenia thrombocytopenia NN cord-010092-uftc8inx 2621 13 in in IN cord-010092-uftc8inx 2621 14 Oncology Oncology NNP cord-010092-uftc8inx 2621 15 patients patient NNS cord-010092-uftc8inx 2621 16 . . . cord-010092-uftc8inx 2622 1 Platelet platelet NN cord-010092-uftc8inx 2622 2 refractoriness refractoriness NN cord-010092-uftc8inx 2622 3 poses pose VBZ cord-010092-uftc8inx 2622 4 challenge challenge NN cord-010092-uftc8inx 2622 5 due due JJ cord-010092-uftc8inx 2622 6 to to IN cord-010092-uftc8inx 2622 7 alloimmunization alloimmunization NN cord-010092-uftc8inx 2622 8 to to IN cord-010092-uftc8inx 2622 9 HLA HLA NNP cord-010092-uftc8inx 2622 10 and and CC cord-010092-uftc8inx 2622 11 human human JJ cord-010092-uftc8inx 2622 12 platelet platelet NN cord-010092-uftc8inx 2622 13 antigens antigen NNS cord-010092-uftc8inx 2622 14 and and CC cord-010092-uftc8inx 2622 15 is be VBZ cord-010092-uftc8inx 2622 16 associated associate VBN cord-010092-uftc8inx 2622 17 with with IN cord-010092-uftc8inx 2622 18 adverse adverse JJ cord-010092-uftc8inx 2622 19 clinical clinical JJ cord-010092-uftc8inx 2622 20 outcomes outcome NNS cord-010092-uftc8inx 2622 21 . . . cord-010092-uftc8inx 2623 1 Aims aim VBZ cord-010092-uftc8inx 2623 2 : : : cord-010092-uftc8inx 2624 1 A a DT cord-010092-uftc8inx 2624 2 prospective prospective JJ cord-010092-uftc8inx 2624 3 study study NN cord-010092-uftc8inx 2624 4 was be VBD cord-010092-uftc8inx 2624 5 undertaken undertake VBN cord-010092-uftc8inx 2624 6 to to TO cord-010092-uftc8inx 2624 7 analyse analyse VB cord-010092-uftc8inx 2624 8 result result NN cord-010092-uftc8inx 2624 9 of of IN cord-010092-uftc8inx 2624 10 platelet platelet NN cord-010092-uftc8inx 2624 11 compatibility compatibility NN cord-010092-uftc8inx 2624 12 with with IN cord-010092-uftc8inx 2624 13 post post JJ cord-010092-uftc8inx 2624 14 - - JJ cord-010092-uftc8inx 2624 15 transfusion transfusion JJ cord-010092-uftc8inx 2624 16 platelet platelet NN cord-010092-uftc8inx 2624 17 count count NN cord-010092-uftc8inx 2624 18 increment increment NN cord-010092-uftc8inx 2624 19 and and CC cord-010092-uftc8inx 2624 20 to to TO cord-010092-uftc8inx 2624 21 ascertain ascertain VB cord-010092-uftc8inx 2624 22 presence presence NN cord-010092-uftc8inx 2624 23 of of IN cord-010092-uftc8inx 2624 24 platelet platelet NN cord-010092-uftc8inx 2624 25 antibodies antibody NNS cord-010092-uftc8inx 2624 26 as as IN cord-010092-uftc8inx 2624 27 causative causative JJ cord-010092-uftc8inx 2624 28 factor factor NN cord-010092-uftc8inx 2624 29 in in IN cord-010092-uftc8inx 2624 30 platelet platelet NN cord-010092-uftc8inx 2624 31 refractory refractory JJ cord-010092-uftc8inx 2624 32 oncology oncology NN cord-010092-uftc8inx 2624 33 patients patient NNS cord-010092-uftc8inx 2624 34 . . . cord-010092-uftc8inx 2625 1 Pulmonary pulmonary JJ cord-010092-uftc8inx 2625 2 complication complication NN cord-010092-uftc8inx 2625 3 after after IN cord-010092-uftc8inx 2625 4 blood blood NN cord-010092-uftc8inx 2625 5 transfusion transfusion NN cord-010092-uftc8inx 2625 6 is be VBZ cord-010092-uftc8inx 2625 7 the the DT cord-010092-uftc8inx 2625 8 leading leading JJ cord-010092-uftc8inx 2625 9 cause cause NN cord-010092-uftc8inx 2625 10 of of IN cord-010092-uftc8inx 2625 11 transfusionrelated transfusionrelated JJ cord-010092-uftc8inx 2625 12 morbidity morbidity NN cord-010092-uftc8inx 2625 13 and and CC cord-010092-uftc8inx 2625 14 mortality mortality NN cord-010092-uftc8inx 2625 15 , , , cord-010092-uftc8inx 2625 16 with with IN cord-010092-uftc8inx 2625 17 an an DT cord-010092-uftc8inx 2625 18 incidence incidence NN cord-010092-uftc8inx 2625 19 reported report VBN cord-010092-uftc8inx 2625 20 between between IN cord-010092-uftc8inx 2625 21 0.05 0.05 CD cord-010092-uftc8inx 2625 22 -15 -15 CD cord-010092-uftc8inx 2625 23 % % NN cord-010092-uftc8inx 2625 24 of of IN cord-010092-uftc8inx 2625 25 all all DT cord-010092-uftc8inx 2625 26 transfused transfuse VBN cord-010092-uftc8inx 2625 27 patients patient NNS cord-010092-uftc8inx 2625 28 . . . cord-010092-uftc8inx 2626 1 The the DT cord-010092-uftc8inx 2626 2 most most RBS cord-010092-uftc8inx 2626 3 important important JJ cord-010092-uftc8inx 2626 4 transfusion transfusion NN cord-010092-uftc8inx 2626 5 related relate VBN cord-010092-uftc8inx 2626 6 pulmonary pulmonary JJ cord-010092-uftc8inx 2626 7 complications complication NNS cord-010092-uftc8inx 2626 8 are be VBP cord-010092-uftc8inx 2626 9 transfusion transfusion NN cord-010092-uftc8inx 2626 10 associated associate VBN cord-010092-uftc8inx 2626 11 circulatory circulatory JJ cord-010092-uftc8inx 2626 12 overload overload NN cord-010092-uftc8inx 2626 13 ( ( -LRB- cord-010092-uftc8inx 2626 14 TACO TACO NNP cord-010092-uftc8inx 2626 15 ) ) -RRB- cord-010092-uftc8inx 2626 16 , , , cord-010092-uftc8inx 2626 17 transfusion transfusion NN cord-010092-uftc8inx 2626 18 related relate VBD cord-010092-uftc8inx 2626 19 acute acute JJ cord-010092-uftc8inx 2626 20 lung lung NN cord-010092-uftc8inx 2626 21 injury injury NN cord-010092-uftc8inx 2626 22 ( ( -LRB- cord-010092-uftc8inx 2626 23 TRALI TRALI NNP cord-010092-uftc8inx 2626 24 ) ) -RRB- cord-010092-uftc8inx 2626 25 and and CC cord-010092-uftc8inx 2626 26 transfusion transfusion NN cord-010092-uftc8inx 2626 27 associated associate VBN cord-010092-uftc8inx 2626 28 dyspnea dyspnea NN cord-010092-uftc8inx 2626 29 ( ( -LRB- cord-010092-uftc8inx 2626 30 TAD TAD NNP cord-010092-uftc8inx 2626 31 ) ) -RRB- cord-010092-uftc8inx 2626 32 . . . cord-010092-uftc8inx 2627 1 In in IN cord-010092-uftc8inx 2627 2 this this DT cord-010092-uftc8inx 2627 3 presentation presentation NN cord-010092-uftc8inx 2627 4 the the DT cord-010092-uftc8inx 2627 5 recent recent JJ cord-010092-uftc8inx 2627 6 changes change NNS cord-010092-uftc8inx 2627 7 in in IN cord-010092-uftc8inx 2627 8 the the DT cord-010092-uftc8inx 2627 9 international international JJ cord-010092-uftc8inx 2627 10 definitions definition NNS cord-010092-uftc8inx 2627 11 will will MD cord-010092-uftc8inx 2627 12 be be VB cord-010092-uftc8inx 2627 13 presented present VBN cord-010092-uftc8inx 2627 14 and and CC cord-010092-uftc8inx 2627 15 discussed discuss VBN cord-010092-uftc8inx 2627 16 . . . cord-010092-uftc8inx 2628 1 Furthermore furthermore RB cord-010092-uftc8inx 2628 2 , , , cord-010092-uftc8inx 2628 3 insights insight NNS cord-010092-uftc8inx 2628 4 in in IN cord-010092-uftc8inx 2628 5 the the DT cord-010092-uftc8inx 2628 6 different different JJ cord-010092-uftc8inx 2628 7 underlying underlying JJ cord-010092-uftc8inx 2628 8 pathophysiologic pathophysiologic NN cord-010092-uftc8inx 2628 9 mechanisms mechanism NNS cord-010092-uftc8inx 2628 10 will will MD cord-010092-uftc8inx 2628 11 be be VB cord-010092-uftc8inx 2628 12 highlighted highlight VBN cord-010092-uftc8inx 2628 13 . . . cord-010092-uftc8inx 2629 1 In in IN cord-010092-uftc8inx 2629 2 the the DT cord-010092-uftc8inx 2629 3 past past JJ cord-010092-uftc8inx 2629 4 decades decade NNS cord-010092-uftc8inx 2629 5 only only RB cord-010092-uftc8inx 2629 6 for for IN cord-010092-uftc8inx 2629 7 TRALI TRALI NNP cord-010092-uftc8inx 2629 8 prevention prevention NN cord-010092-uftc8inx 2629 9 strategies strategy NNS cord-010092-uftc8inx 2629 10 have have VBP cord-010092-uftc8inx 2629 11 successfully successfully RB cord-010092-uftc8inx 2629 12 been be VBN cord-010092-uftc8inx 2629 13 designed design VBN cord-010092-uftc8inx 2629 14 and and CC cord-010092-uftc8inx 2629 15 implemented implement VBN cord-010092-uftc8inx 2629 16 . . . cord-010092-uftc8inx 2630 1 Currently currently RB cord-010092-uftc8inx 2630 2 no no DT cord-010092-uftc8inx 2630 3 evidencebased evidencebased JJ cord-010092-uftc8inx 2630 4 treatment treatment NN cord-010092-uftc8inx 2630 5 strategy strategy NN cord-010092-uftc8inx 2630 6 is be VBZ cord-010092-uftc8inx 2630 7 available available JJ cord-010092-uftc8inx 2630 8 for for IN cord-010092-uftc8inx 2630 9 any any DT cord-010092-uftc8inx 2630 10 of of IN cord-010092-uftc8inx 2630 11 these these DT cord-010092-uftc8inx 2630 12 life life NN cord-010092-uftc8inx 2630 13 - - HYPH cord-010092-uftc8inx 2630 14 threatening threaten VBG cord-010092-uftc8inx 2630 15 syndromes syndrome NNS cord-010092-uftc8inx 2630 16 . . . cord-010092-uftc8inx 2631 1 Insight insight NN cord-010092-uftc8inx 2631 2 in in IN cord-010092-uftc8inx 2631 3 the the DT cord-010092-uftc8inx 2631 4 pathogenesis pathogenesis NN cord-010092-uftc8inx 2631 5 of of IN cord-010092-uftc8inx 2631 6 pulmonary pulmonary JJ cord-010092-uftc8inx 2631 7 complications complication NNS cord-010092-uftc8inx 2631 8 after after IN cord-010092-uftc8inx 2631 9 transfusion transfusion NN cord-010092-uftc8inx 2631 10 should should MD cord-010092-uftc8inx 2631 11 pave pave VB cord-010092-uftc8inx 2631 12 the the DT cord-010092-uftc8inx 2631 13 way way NN cord-010092-uftc8inx 2631 14 for for IN cord-010092-uftc8inx 2631 15 future future JJ cord-010092-uftc8inx 2631 16 prevention prevention NN cord-010092-uftc8inx 2631 17 and and CC cord-010092-uftc8inx 2631 18 treatment treatment NN cord-010092-uftc8inx 2631 19 studies study NNS cord-010092-uftc8inx 2631 20 . . . cord-010092-uftc8inx 2632 1 The the DT cord-010092-uftc8inx 2632 2 issue issue NN cord-010092-uftc8inx 2632 3 of of IN cord-010092-uftc8inx 2632 4 the the DT cord-010092-uftc8inx 2632 5 impact impact NN cord-010092-uftc8inx 2632 6 of of IN cord-010092-uftc8inx 2632 7 iron iron NN cord-010092-uftc8inx 2632 8 overload overload NN cord-010092-uftc8inx 2632 9 / / SYM cord-010092-uftc8inx 2632 10 toxicity toxicity NN cord-010092-uftc8inx 2632 11 on on IN cord-010092-uftc8inx 2632 12 the the DT cord-010092-uftc8inx 2632 13 hematopoietic hematopoietic JJ cord-010092-uftc8inx 2632 14 stem stem NN cord-010092-uftc8inx 2632 15 transplantation transplantation NN cord-010092-uftc8inx 2632 16 ( ( -LRB- cord-010092-uftc8inx 2632 17 HCT HCT NNP cord-010092-uftc8inx 2632 18 ) ) -RRB- cord-010092-uftc8inx 2632 19 outcome outcome NN cord-010092-uftc8inx 2632 20 has have VBZ cord-010092-uftc8inx 2632 21 been be VBN cord-010092-uftc8inx 2632 22 firstly firstly RB cord-010092-uftc8inx 2632 23 addressed address VBN cord-010092-uftc8inx 2632 24 in in IN cord-010092-uftc8inx 2632 25 the the DT cord-010092-uftc8inx 2632 26 field field NN cord-010092-uftc8inx 2632 27 of of IN cord-010092-uftc8inx 2632 28 transfusion transfusion NN cord-010092-uftc8inx 2632 29 dependent dependent JJ cord-010092-uftc8inx 2632 30 thalassemia thalassemia NN cord-010092-uftc8inx 2632 31 . . . cord-010092-uftc8inx 2633 1 Today today NN cord-010092-uftc8inx 2633 2 the the DT cord-010092-uftc8inx 2633 3 concept concept NN cord-010092-uftc8inx 2633 4 has have VBZ cord-010092-uftc8inx 2633 5 been be VBN cord-010092-uftc8inx 2633 6 extended extend VBN cord-010092-uftc8inx 2633 7 to to IN cord-010092-uftc8inx 2633 8 other other JJ cord-010092-uftc8inx 2633 9 diseases disease NNS cord-010092-uftc8inx 2633 10 characterized characterize VBN cord-010092-uftc8inx 2633 11 by by IN cord-010092-uftc8inx 2633 12 periods period NNS cord-010092-uftc8inx 2633 13 of of IN cord-010092-uftc8inx 2633 14 variable variable JJ cord-010092-uftc8inx 2633 15 duration duration NN cord-010092-uftc8inx 2633 16 of of IN cord-010092-uftc8inx 2633 17 transfusion transfusion NN cord-010092-uftc8inx 2633 18 dependence dependence NN cord-010092-uftc8inx 2633 19 such such JJ cord-010092-uftc8inx 2633 20 as as IN cord-010092-uftc8inx 2633 21 Myelodysplastic Myelodysplastic NNP cord-010092-uftc8inx 2633 22 Syndrome Syndrome NNP cord-010092-uftc8inx 2633 23 ( ( -LRB- cord-010092-uftc8inx 2633 24 MDS MDS NNP cord-010092-uftc8inx 2633 25 ) ) -RRB- cord-010092-uftc8inx 2633 26 and and CC cord-010092-uftc8inx 2633 27 myeloproliferative myeloproliferative JJ cord-010092-uftc8inx 2633 28 diseases disease NNS cord-010092-uftc8inx 2633 29 . . . cord-010092-uftc8inx 2634 1 Patients patient NNS cord-010092-uftc8inx 2634 2 requiring require VBG cord-010092-uftc8inx 2634 3 regular regular JJ cord-010092-uftc8inx 2634 4 blood blood NN cord-010092-uftc8inx 2634 5 transfusions transfusion NNS cord-010092-uftc8inx 2634 6 certainly certainly RB cord-010092-uftc8inx 2634 7 develop develop VBP cord-010092-uftc8inx 2634 8 iron iron NN cord-010092-uftc8inx 2634 9 overload overload NN cord-010092-uftc8inx 2634 10 leading lead VBG cord-010092-uftc8inx 2634 11 to to IN cord-010092-uftc8inx 2634 12 tissues tissue NNS cord-010092-uftc8inx 2634 13 and and CC cord-010092-uftc8inx 2634 14 organ organ NN cord-010092-uftc8inx 2634 15 damage damage NN cord-010092-uftc8inx 2634 16 . . . cord-010092-uftc8inx 2635 1 Iron iron NN cord-010092-uftc8inx 2635 2 burden burden NN cord-010092-uftc8inx 2635 3 before before IN cord-010092-uftc8inx 2635 4 transplant transplant NN cord-010092-uftc8inx 2635 5 significantly significantly RB cord-010092-uftc8inx 2635 6 impacts impact VBZ cord-010092-uftc8inx 2635 7 outcome outcome NN cord-010092-uftc8inx 2635 8 and and CC cord-010092-uftc8inx 2635 9 long long JJ cord-010092-uftc8inx 2635 10 - - HYPH cord-010092-uftc8inx 2635 11 life life NN cord-010092-uftc8inx 2635 12 posttransplant posttransplant NN cord-010092-uftc8inx 2635 13 . . . cord-010092-uftc8inx 2636 1 It -PRON- PRP cord-010092-uftc8inx 2636 2 is be VBZ cord-010092-uftc8inx 2636 3 well well RB cord-010092-uftc8inx 2636 4 known know VBN cord-010092-uftc8inx 2636 5 that that IN cord-010092-uftc8inx 2636 6 iron iron NN cord-010092-uftc8inx 2636 7 overload overload NN cord-010092-uftc8inx 2636 8 is be VBZ cord-010092-uftc8inx 2636 9 deleterious deleterious JJ cord-010092-uftc8inx 2636 10 for for IN cord-010092-uftc8inx 2636 11 organs organ NNS cord-010092-uftc8inx 2636 12 such such JJ cord-010092-uftc8inx 2636 13 as as IN cord-010092-uftc8inx 2636 14 liver liver NN cord-010092-uftc8inx 2636 15 , , , cord-010092-uftc8inx 2636 16 heart heart NN cord-010092-uftc8inx 2636 17 and and CC cord-010092-uftc8inx 2636 18 endocrine endocrine JJ cord-010092-uftc8inx 2636 19 glands gland NNS cord-010092-uftc8inx 2636 20 and and CC cord-010092-uftc8inx 2636 21 it -PRON- PRP cord-010092-uftc8inx 2636 22 has have VBZ cord-010092-uftc8inx 2636 23 been be VBN cord-010092-uftc8inx 2636 24 postulated postulate VBN cord-010092-uftc8inx 2636 25 could could MD cord-010092-uftc8inx 2636 26 also also RB cord-010092-uftc8inx 2636 27 increases increase VBZ cord-010092-uftc8inx 2636 28 the the DT cord-010092-uftc8inx 2636 29 risk risk NN cord-010092-uftc8inx 2636 30 of of IN cord-010092-uftc8inx 2636 31 infections infection NNS cord-010092-uftc8inx 2636 32 and and CC cord-010092-uftc8inx 2636 33 severe severe JJ cord-010092-uftc8inx 2636 34 Graft graft NN cord-010092-uftc8inx 2636 35 versus versus IN cord-010092-uftc8inx 2636 36 Host Host NNP cord-010092-uftc8inx 2636 37 Disease Disease NNP cord-010092-uftc8inx 2636 38 early early RB cord-010092-uftc8inx 2636 39 after after IN cord-010092-uftc8inx 2636 40 HCT HCT NNP cord-010092-uftc8inx 2636 41 . . . cord-010092-uftc8inx 2637 1 Recent recent JJ cord-010092-uftc8inx 2637 2 preclinical preclinical JJ cord-010092-uftc8inx 2637 3 data datum NNS cord-010092-uftc8inx 2637 4 has have VBZ cord-010092-uftc8inx 2637 5 shown show VBN cord-010092-uftc8inx 2637 6 how how WRB cord-010092-uftc8inx 2637 7 increased increase VBN cord-010092-uftc8inx 2637 8 production production NN cord-010092-uftc8inx 2637 9 of of IN cord-010092-uftc8inx 2637 10 reactive reactive JJ cord-010092-uftc8inx 2637 11 oxygen oxygen NN cord-010092-uftc8inx 2637 12 species specie NNS cord-010092-uftc8inx 2637 13 ( ( -LRB- cord-010092-uftc8inx 2637 14 ROS ROS NNP cord-010092-uftc8inx 2637 15 ) ) -RRB- cord-010092-uftc8inx 2637 16 resulting result VBG cord-010092-uftc8inx 2637 17 under under IN cord-010092-uftc8inx 2637 18 iron iron NN cord-010092-uftc8inx 2637 19 overload overload NN cord-010092-uftc8inx 2637 20 condition condition NN cord-010092-uftc8inx 2637 21 , , , cord-010092-uftc8inx 2637 22 could could MD cord-010092-uftc8inx 2637 23 impair impair VB cord-010092-uftc8inx 2637 24 the the DT cord-010092-uftc8inx 2637 25 stem stem NN cord-010092-uftc8inx 2637 26 cells cell NNS cord-010092-uftc8inx 2637 27 clonality clonality NN cord-010092-uftc8inx 2637 28 capacity capacity NN cord-010092-uftc8inx 2637 29 , , , cord-010092-uftc8inx 2637 30 proliferation proliferation NN cord-010092-uftc8inx 2637 31 and and CC cord-010092-uftc8inx 2637 32 maturation maturation NN cord-010092-uftc8inx 2637 33 . . . cord-010092-uftc8inx 2638 1 Also also RB cord-010092-uftc8inx 2638 2 , , , cord-010092-uftc8inx 2638 3 microenvironment microenvironment NN cord-010092-uftc8inx 2638 4 cells cell NNS cord-010092-uftc8inx 2638 5 could could MD cord-010092-uftc8inx 2638 6 be be VB cord-010092-uftc8inx 2638 7 affected affect VBN cord-010092-uftc8inx 2638 8 through through IN cord-010092-uftc8inx 2638 9 this this DT cord-010092-uftc8inx 2638 10 mechanism mechanism NN cord-010092-uftc8inx 2638 11 . . . cord-010092-uftc8inx 2639 1 For for IN cord-010092-uftc8inx 2639 2 this this DT cord-010092-uftc8inx 2639 3 reason reason NN cord-010092-uftc8inx 2639 4 , , , cord-010092-uftc8inx 2639 5 iron iron NN cord-010092-uftc8inx 2639 6 overload overload NN cord-010092-uftc8inx 2639 7 is be VBZ cord-010092-uftc8inx 2639 8 becoming become VBG cord-010092-uftc8inx 2639 9 an an DT cord-010092-uftc8inx 2639 10 important important JJ cord-010092-uftc8inx 2639 11 issue issue NN cord-010092-uftc8inx 2639 12 also also RB cord-010092-uftc8inx 2639 13 in in IN cord-010092-uftc8inx 2639 14 the the DT cord-010092-uftc8inx 2639 15 engraftment engraftment NN cord-010092-uftc8inx 2639 16 period period NN cord-010092-uftc8inx 2639 17 early early JJ cord-010092-uftc8inx 2639 18 post post JJ cord-010092-uftc8inx 2639 19 - - NN cord-010092-uftc8inx 2639 20 transplant transplant NN cord-010092-uftc8inx 2639 21 . . . cord-010092-uftc8inx 2640 1 High high JJ cord-010092-uftc8inx 2640 2 baseline baseline JJ cord-010092-uftc8inx 2640 3 Ferritin ferritin NN cord-010092-uftc8inx 2640 4 levels level NNS cord-010092-uftc8inx 2640 5 before before IN cord-010092-uftc8inx 2640 6 HCT HCT NNP cord-010092-uftc8inx 2640 7 have have VBP cord-010092-uftc8inx 2640 8 been be VBN cord-010092-uftc8inx 2640 9 shown show VBN cord-010092-uftc8inx 2640 10 to to TO cord-010092-uftc8inx 2640 11 negatively negatively RB cord-010092-uftc8inx 2640 12 influence influence VB cord-010092-uftc8inx 2640 13 clinical clinical JJ cord-010092-uftc8inx 2640 14 outcome outcome NN cord-010092-uftc8inx 2640 15 , , , cord-010092-uftc8inx 2640 16 but but CC cord-010092-uftc8inx 2640 17 nowadays nowadays RB cord-010092-uftc8inx 2640 18 , , , cord-010092-uftc8inx 2640 19 ferritin ferritin NN cord-010092-uftc8inx 2640 20 is be VBZ cord-010092-uftc8inx 2640 21 considered consider VBN cord-010092-uftc8inx 2640 22 a a DT cord-010092-uftc8inx 2640 23 steady steady JJ cord-010092-uftc8inx 2640 24 and and CC cord-010092-uftc8inx 2640 25 not not RB cord-010092-uftc8inx 2640 26 biologically biologically RB cord-010092-uftc8inx 2640 27 active active JJ cord-010092-uftc8inx 2640 28 form form NN cord-010092-uftc8inx 2640 29 of of IN cord-010092-uftc8inx 2640 30 iron iron NN cord-010092-uftc8inx 2640 31 , , , cord-010092-uftc8inx 2640 32 while while IN cord-010092-uftc8inx 2640 33 free free JJ cord-010092-uftc8inx 2640 34 iron iron NN cord-010092-uftc8inx 2640 35 forms form NNS cord-010092-uftc8inx 2640 36 as as IN cord-010092-uftc8inx 2640 37 non non JJ cord-010092-uftc8inx 2640 38 -transferrin -transferrin JJ cord-010092-uftc8inx 2640 39 bound bound JJ cord-010092-uftc8inx 2640 40 iron iron NN cord-010092-uftc8inx 2640 41 ( ( -LRB- cord-010092-uftc8inx 2640 42 NTBI NTBI NNP cord-010092-uftc8inx 2640 43 ) ) -RRB- cord-010092-uftc8inx 2640 44 and and CC cord-010092-uftc8inx 2640 45 labile labile JJ cord-010092-uftc8inx 2640 46 plasma plasma NN cord-010092-uftc8inx 2640 47 iron iron NN cord-010092-uftc8inx 2640 48 ( ( -LRB- cord-010092-uftc8inx 2640 49 LPI LPI NNP cord-010092-uftc8inx 2640 50 ) ) -RRB- cord-010092-uftc8inx 2640 51 are be VBP cord-010092-uftc8inx 2640 52 considered consider VBN cord-010092-uftc8inx 2640 53 the the DT cord-010092-uftc8inx 2640 54 main main JJ cord-010092-uftc8inx 2640 55 trigger trigger NN cord-010092-uftc8inx 2640 56 of of IN cord-010092-uftc8inx 2640 57 cell cell NN cord-010092-uftc8inx 2640 58 damage damage NN cord-010092-uftc8inx 2640 59 more more JJR cord-010092-uftc8inx 2640 60 representative representative NN cord-010092-uftc8inx 2640 61 of of IN cord-010092-uftc8inx 2640 62 the the DT cord-010092-uftc8inx 2640 63 dynamic dynamic JJ cord-010092-uftc8inx 2640 64 tissue tissue NN cord-010092-uftc8inx 2640 65 damage damage NN cord-010092-uftc8inx 2640 66 . . . cord-010092-uftc8inx 2641 1 The the DT cord-010092-uftc8inx 2641 2 scientific scientific JJ cord-010092-uftc8inx 2641 3 community community NN cord-010092-uftc8inx 2641 4 is be VBZ cord-010092-uftc8inx 2641 5 moving move VBG cord-010092-uftc8inx 2641 6 the the DT cord-010092-uftc8inx 2641 7 iron iron NN cord-010092-uftc8inx 2641 8 disease disease NN cord-010092-uftc8inx 2641 9 from from IN cord-010092-uftc8inx 2641 10 a a DT cord-010092-uftc8inx 2641 11 " " `` cord-010092-uftc8inx 2641 12 Bulky bulky JJ cord-010092-uftc8inx 2641 13 " " '' cord-010092-uftc8inx 2641 14 disease disease NN cord-010092-uftc8inx 2641 15 , , , cord-010092-uftc8inx 2641 16 such such JJ cord-010092-uftc8inx 2641 17 as as IN cord-010092-uftc8inx 2641 18 classically classically RB cord-010092-uftc8inx 2641 19 in in IN cord-010092-uftc8inx 2641 20 thalassemia thalassemia NN cord-010092-uftc8inx 2641 21 ( ( -LRB- cord-010092-uftc8inx 2641 22 based base VBN cord-010092-uftc8inx 2641 23 on on IN cord-010092-uftc8inx 2641 24 quantitative quantitative JJ cord-010092-uftc8inx 2641 25 iron iron NN cord-010092-uftc8inx 2641 26 parameters parameter NNS cord-010092-uftc8inx 2641 27 as as IN cord-010092-uftc8inx 2641 28 ferritin ferritin NN cord-010092-uftc8inx 2641 29 , , , cord-010092-uftc8inx 2641 30 red red JJ cord-010092-uftc8inx 2641 31 blood blood NN cord-010092-uftc8inx 2641 32 cell cell NN cord-010092-uftc8inx 2641 33 transfusion transfusion NN cord-010092-uftc8inx 2641 34 number number NN cord-010092-uftc8inx 2641 35 , , , cord-010092-uftc8inx 2641 36 MRI MRI NNP cord-010092-uftc8inx 2641 37 ) ) -RRB- cord-010092-uftc8inx 2641 38 to to IN cord-010092-uftc8inx 2641 39 a a DT cord-010092-uftc8inx 2641 40 " " `` cord-010092-uftc8inx 2641 41 toxic toxic JJ cord-010092-uftc8inx 2641 42 " " '' cord-010092-uftc8inx 2641 43 disease disease NN cord-010092-uftc8inx 2641 44 ( ( -LRB- cord-010092-uftc8inx 2641 45 based base VBN cord-010092-uftc8inx 2641 46 on on IN cord-010092-uftc8inx 2641 47 active active JJ cord-010092-uftc8inx 2641 48 and and CC cord-010092-uftc8inx 2641 49 dynamic dynamic JJ cord-010092-uftc8inx 2641 50 biological biological JJ cord-010092-uftc8inx 2641 51 markers marker NNS cord-010092-uftc8inx 2641 52 as as IN cord-010092-uftc8inx 2641 53 NTBI NTBI NNP cord-010092-uftc8inx 2641 54 / / SYM cord-010092-uftc8inx 2641 55 LPI LPI NNP cord-010092-uftc8inx 2641 56 ) ) -RRB- cord-010092-uftc8inx 2641 57 . . . cord-010092-uftc8inx 2642 1 At at IN cord-010092-uftc8inx 2642 2 this this DT cord-010092-uftc8inx 2642 3 time time NN cord-010092-uftc8inx 2642 4 in in IN cord-010092-uftc8inx 2642 5 all all PDT cord-010092-uftc8inx 2642 6 the the DT cord-010092-uftc8inx 2642 7 studies study NNS cord-010092-uftc8inx 2642 8 published publish VBN cord-010092-uftc8inx 2642 9 on on IN cord-010092-uftc8inx 2642 10 HCT hct NN cord-010092-uftc8inx 2642 11 setting setting NN cord-010092-uftc8inx 2642 12 , , , cord-010092-uftc8inx 2642 13 only only RB cord-010092-uftc8inx 2642 14 the the DT cord-010092-uftc8inx 2642 15 correlation correlation NN cord-010092-uftc8inx 2642 16 between between IN cord-010092-uftc8inx 2642 17 direct direct JJ cord-010092-uftc8inx 2642 18 or or CC cord-010092-uftc8inx 2642 19 indirect indirect JJ cord-010092-uftc8inx 2642 20 estimates estimate NNS cord-010092-uftc8inx 2642 21 of of IN cord-010092-uftc8inx 2642 22 iron iron NN cord-010092-uftc8inx 2642 23 overload overload NN cord-010092-uftc8inx 2642 24 ( ( -LRB- cord-010092-uftc8inx 2642 25 mainly mainly RB cord-010092-uftc8inx 2642 26 serum serum NN cord-010092-uftc8inx 2642 27 ferritin ferritin NN cord-010092-uftc8inx 2642 28 ) ) -RRB- cord-010092-uftc8inx 2642 29 and and CC cord-010092-uftc8inx 2642 30 outcome outcome NN cord-010092-uftc8inx 2642 31 parameters parameter NNS cord-010092-uftc8inx 2642 32 has have VBZ cord-010092-uftc8inx 2642 33 been be VBN cord-010092-uftc8inx 2642 34 explored explore VBN cord-010092-uftc8inx 2642 35 , , , cord-010092-uftc8inx 2642 36 while while IN cord-010092-uftc8inx 2642 37 the the DT cord-010092-uftc8inx 2642 38 duration duration NN cord-010092-uftc8inx 2642 39 of of IN cord-010092-uftc8inx 2642 40 exposure exposure NN cord-010092-uftc8inx 2642 41 to to IN cord-010092-uftc8inx 2642 42 toxic toxic JJ cord-010092-uftc8inx 2642 43 iron iron NN cord-010092-uftc8inx 2642 44 species specie NNS cord-010092-uftc8inx 2642 45 has have VBZ cord-010092-uftc8inx 2642 46 not not RB cord-010092-uftc8inx 2642 47 been be VBN cord-010092-uftc8inx 2642 48 taken take VBN cord-010092-uftc8inx 2642 49 into into IN cord-010092-uftc8inx 2642 50 account account NN cord-010092-uftc8inx 2642 51 . . . cord-010092-uftc8inx 2643 1 The the DT cord-010092-uftc8inx 2643 2 first first JJ cord-010092-uftc8inx 2643 3 study study NN cord-010092-uftc8inx 2643 4 that that WDT cord-010092-uftc8inx 2643 5 explored explore VBD cord-010092-uftc8inx 2643 6 the the DT cord-010092-uftc8inx 2643 7 LPI LPI NNP cord-010092-uftc8inx 2643 8 role role NN cord-010092-uftc8inx 2643 9 in in IN cord-010092-uftc8inx 2643 10 relationship relationship NN cord-010092-uftc8inx 2643 11 with with IN cord-010092-uftc8inx 2643 12 outcome outcome NN cord-010092-uftc8inx 2643 13 was be VBD cord-010092-uftc8inx 2643 14 published publish VBN cord-010092-uftc8inx 2643 15 by by IN cord-010092-uftc8inx 2643 16 Wermke Wermke NNP cord-010092-uftc8inx 2643 17 and and CC cord-010092-uftc8inx 2643 18 colleagues colleague NNS cord-010092-uftc8inx 2643 19 in in IN cord-010092-uftc8inx 2643 20 malignancies malignancy NNS cord-010092-uftc8inx 2643 21 . . . cord-010092-uftc8inx 2644 1 They -PRON- PRP cord-010092-uftc8inx 2644 2 investigated investigate VBD cord-010092-uftc8inx 2644 3 the the DT cord-010092-uftc8inx 2644 4 predictive predictive JJ cord-010092-uftc8inx 2644 5 value value NN cord-010092-uftc8inx 2644 6 of of IN cord-010092-uftc8inx 2644 7 both both DT cord-010092-uftc8inx 2644 8 stored store VBN cord-010092-uftc8inx 2644 9 ( ( -LRB- cord-010092-uftc8inx 2644 10 MRI MRI NNP cord-010092-uftc8inx 2644 11 - - HYPH cord-010092-uftc8inx 2644 12 derived derive VBN cord-010092-uftc8inx 2644 13 liver liver NN cord-010092-uftc8inx 2644 14 iron iron NN cord-010092-uftc8inx 2644 15 content content NN cord-010092-uftc8inx 2644 16 ) ) -RRB- cord-010092-uftc8inx 2644 17 and and CC cord-010092-uftc8inx 2644 18 non non JJ cord-010092-uftc8inx 2644 19 - - JJ cord-010092-uftc8inx 2644 20 transferrin transferrin JJ cord-010092-uftc8inx 2644 21 - - HYPH cord-010092-uftc8inx 2644 22 bound bind VBN cord-010092-uftc8inx 2644 23 - - HYPH cord-010092-uftc8inx 2644 24 iron iron NN cord-010092-uftc8inx 2644 25 , , , cord-010092-uftc8inx 2644 26 defined define VBN cord-010092-uftc8inx 2644 27 as as IN cord-010092-uftc8inx 2644 28 enhanced enhanced JJ cord-010092-uftc8inx 2644 29 labile labile JJ cord-010092-uftc8inx 2644 30 plasma plasma NN cord-010092-uftc8inx 2644 31 iron iron NN cord-010092-uftc8inx 2644 32 ( ( -LRB- cord-010092-uftc8inx 2644 33 eLPI eLPI '' cord-010092-uftc8inx 2644 34 ) ) -RRB- cord-010092-uftc8inx 2644 35 on on IN cord-010092-uftc8inx 2644 36 post post JJ cord-010092-uftc8inx 2644 37 - - JJ cord-010092-uftc8inx 2644 38 transplantation transplantation JJ cord-010092-uftc8inx 2644 39 outcomes outcome NNS cord-010092-uftc8inx 2644 40 in in IN cord-010092-uftc8inx 2644 41 patients patient NNS cord-010092-uftc8inx 2644 42 with with IN cord-010092-uftc8inx 2644 43 acute acute JJ cord-010092-uftc8inx 2644 44 myeloid myeloid JJ cord-010092-uftc8inx 2644 45 leukemia leukemia NN cord-010092-uftc8inx 2644 46 or or CC cord-010092-uftc8inx 2644 47 MDS MDS NNP cord-010092-uftc8inx 2644 48 . . . cord-010092-uftc8inx 2645 1 Their -PRON- PRP$ cord-010092-uftc8inx 2645 2 prospective prospective JJ cord-010092-uftc8inx 2645 3 , , , cord-010092-uftc8inx 2645 4 observational observational JJ cord-010092-uftc8inx 2645 5 ALL all RB cord-010092-uftc8inx 2645 6 - - HYPH cord-010092-uftc8inx 2645 7 IVE IVE NNP cord-010092-uftc8inx 2645 8 study study NN cord-010092-uftc8inx 2645 9 showed show VBD cord-010092-uftc8inx 2645 10 that that IN cord-010092-uftc8inx 2645 11 patients patient NNS cord-010092-uftc8inx 2645 12 who who WP cord-010092-uftc8inx 2645 13 had have VBD cord-010092-uftc8inx 2645 14 raised raise VBN cord-010092-uftc8inx 2645 15 eLPI eLPI `` cord-010092-uftc8inx 2645 16 concentration concentration NN cord-010092-uftc8inx 2645 17 at at IN cord-010092-uftc8inx 2645 18 baseline baseline NN cord-010092-uftc8inx 2645 19 , , , cord-010092-uftc8inx 2645 20 also also RB cord-010092-uftc8inx 2645 21 had have VBD cord-010092-uftc8inx 2645 22 significantly significantly RB cord-010092-uftc8inx 2645 23 increased increase VBN cord-010092-uftc8inx 2645 24 incidence incidence NN cord-010092-uftc8inx 2645 25 of of IN cord-010092-uftc8inx 2645 26 non non JJ cord-010092-uftc8inx 2645 27 - - JJ cord-010092-uftc8inx 2645 28 relapse relapse JJ cord-010092-uftc8inx 2645 29 mortality mortality NN cord-010092-uftc8inx 2645 30 at at IN cord-010092-uftc8inx 2645 31 day day NN cord-010092-uftc8inx 2645 32 100 100 CD cord-010092-uftc8inx 2645 33 ( ( -LRB- cord-010092-uftc8inx 2645 34 33 33 CD cord-010092-uftc8inx 2645 35 % % NN cord-010092-uftc8inx 2645 36 ) ) -RRB- cord-010092-uftc8inx 2645 37 compared compare VBN cord-010092-uftc8inx 2645 38 with with IN cord-010092-uftc8inx 2645 39 those those DT cord-010092-uftc8inx 2645 40 who who WP cord-010092-uftc8inx 2645 41 had have VBD cord-010092-uftc8inx 2645 42 normal normal JJ cord-010092-uftc8inx 2645 43 eLPI elpi XX cord-010092-uftc8inx 2645 44 at at IN cord-010092-uftc8inx 2645 45 baseline baseline NN cord-010092-uftc8inx 2645 46 ( ( -LRB- cord-010092-uftc8inx 2645 47 7 7 CD cord-010092-uftc8inx 2645 48 % % NN cord-010092-uftc8inx 2645 49 ) ) -RRB- cord-010092-uftc8inx 2646 1 ( ( -LRB- cord-010092-uftc8inx 2646 2 P p NN cord-010092-uftc8inx 2646 3 = = SYM cord-010092-uftc8inx 2646 4 0.00034 0.00034 CD cord-010092-uftc8inx 2646 5 ) ) -RRB- cord-010092-uftc8inx 2646 6 . . . cord-010092-uftc8inx 2647 1 Reinterpreting reinterpret VBG cord-010092-uftc8inx 2647 2 transplant transplant NN cord-010092-uftc8inx 2647 3 predictive predictive JJ cord-010092-uftc8inx 2647 4 factors factor NNS cord-010092-uftc8inx 2647 5 in in IN cord-010092-uftc8inx 2647 6 the the DT cord-010092-uftc8inx 2647 7 light light NN cord-010092-uftc8inx 2647 8 of of IN cord-010092-uftc8inx 2647 9 the the DT cord-010092-uftc8inx 2647 10 current current JJ cord-010092-uftc8inx 2647 11 advances advance NNS cord-010092-uftc8inx 2647 12 in in IN cord-010092-uftc8inx 2647 13 understanding understand VBG cord-010092-uftc8inx 2647 14 iron iron NN cord-010092-uftc8inx 2647 15 homeostasis homeostasis NN cord-010092-uftc8inx 2647 16 further further RB cord-010092-uftc8inx 2647 17 supports support VBZ cord-010092-uftc8inx 2647 18 the the DT cord-010092-uftc8inx 2647 19 concept concept NN cord-010092-uftc8inx 2647 20 that that IN cord-010092-uftc8inx 2647 21 the the DT cord-010092-uftc8inx 2647 22 key key NN cord-010092-uftc8inx 2647 23 to to IN cord-010092-uftc8inx 2647 24 successful successful JJ cord-010092-uftc8inx 2647 25 transplantation transplantation NN cord-010092-uftc8inx 2647 26 is be VBZ cord-010092-uftc8inx 2647 27 regular regular JJ cord-010092-uftc8inx 2647 28 and and CC cord-010092-uftc8inx 2647 29 life life NN cord-010092-uftc8inx 2647 30 - - HYPH cord-010092-uftc8inx 2647 31 long long JJ cord-010092-uftc8inx 2647 32 chelation chelation NN cord-010092-uftc8inx 2647 33 therapy therapy NN cord-010092-uftc8inx 2647 34 to to TO cord-010092-uftc8inx 2647 35 consistently consistently RB cord-010092-uftc8inx 2647 36 suppress suppress VB cord-010092-uftc8inx 2647 37 tissue tissue NN cord-010092-uftc8inx 2647 38 reactive reactive JJ cord-010092-uftc8inx 2647 39 iron iron NN cord-010092-uftc8inx 2647 40 species specie NNS cord-010092-uftc8inx 2647 41 and and CC cord-010092-uftc8inx 2647 42 prevent prevent VB cord-010092-uftc8inx 2647 43 tissue tissue NN cord-010092-uftc8inx 2647 44 damage damage NN cord-010092-uftc8inx 2647 45 in in IN cord-010092-uftc8inx 2647 46 the the DT cord-010092-uftc8inx 2647 47 years year NNS cord-010092-uftc8inx 2647 48 before before IN cord-010092-uftc8inx 2647 49 HCT HCT NNP cord-010092-uftc8inx 2647 50 . . . cord-010092-uftc8inx 2648 1 In in IN cord-010092-uftc8inx 2648 2 transfusion transfusion NN cord-010092-uftc8inx 2648 3 medicine medicine NN cord-010092-uftc8inx 2648 4 , , , cord-010092-uftc8inx 2648 5 the the DT cord-010092-uftc8inx 2648 6 role role NN cord-010092-uftc8inx 2648 7 of of IN cord-010092-uftc8inx 2648 8 donor donor NN cord-010092-uftc8inx 2648 9 sex sex NN cord-010092-uftc8inx 2648 10 was be VBD cord-010092-uftc8inx 2648 11 long long RB cord-010092-uftc8inx 2648 12 considered consider VBN cord-010092-uftc8inx 2648 13 to to TO cord-010092-uftc8inx 2648 14 be be VB cord-010092-uftc8inx 2648 15 limited limit VBN cord-010092-uftc8inx 2648 16 to to IN cord-010092-uftc8inx 2648 17 the the DT cord-010092-uftc8inx 2648 18 increased increase VBN cord-010092-uftc8inx 2648 19 risk risk NN cord-010092-uftc8inx 2648 20 of of IN cord-010092-uftc8inx 2648 21 TRALI TRALI NNP cord-010092-uftc8inx 2648 22 observed observe VBD cord-010092-uftc8inx 2648 23 after after IN cord-010092-uftc8inx 2648 24 transfusions transfusion NNS cord-010092-uftc8inx 2648 25 from from IN cord-010092-uftc8inx 2648 26 female female JJ cord-010092-uftc8inx 2648 27 donors donor NNS cord-010092-uftc8inx 2648 28 . . . cord-010092-uftc8inx 2649 1 This this DT cord-010092-uftc8inx 2649 2 risk risk NN cord-010092-uftc8inx 2649 3 has have VBZ cord-010092-uftc8inx 2649 4 been be VBN cord-010092-uftc8inx 2649 5 shown show VBN cord-010092-uftc8inx 2649 6 to to TO cord-010092-uftc8inx 2649 7 be be VB cord-010092-uftc8inx 2649 8 limited limit VBN cord-010092-uftc8inx 2649 9 to to IN cord-010092-uftc8inx 2649 10 female female JJ cord-010092-uftc8inx 2649 11 donors donor NNS cord-010092-uftc8inx 2649 12 with with IN cord-010092-uftc8inx 2649 13 a a DT cord-010092-uftc8inx 2649 14 history history NN cord-010092-uftc8inx 2649 15 of of IN cord-010092-uftc8inx 2649 16 pregnancy pregnancy NN cord-010092-uftc8inx 2649 17 and and CC cord-010092-uftc8inx 2649 18 to to TO cord-010092-uftc8inx 2649 19 plasma plasma VB cord-010092-uftc8inx 2649 20 rich rich JJ cord-010092-uftc8inx 2649 21 products product NNS cord-010092-uftc8inx 2649 22 ( ( -LRB- cord-010092-uftc8inx 2649 23 i.e. i.e. FW cord-010092-uftc8inx 2649 24 excluding exclude VBG cord-010092-uftc8inx 2649 25 red red JJ cord-010092-uftc8inx 2649 26 blood blood NN cord-010092-uftc8inx 2649 27 cell cell NN cord-010092-uftc8inx 2649 28 products product NNS cord-010092-uftc8inx 2649 29 , , , cord-010092-uftc8inx 2649 30 typically typically RB cord-010092-uftc8inx 2649 31 containing contain VBG cord-010092-uftc8inx 2649 32 < < XX cord-010092-uftc8inx 2649 33 50 50 CD cord-010092-uftc8inx 2649 34 mL ml NN cord-010092-uftc8inx 2649 35 plasma plasma NN cord-010092-uftc8inx 2649 36 ) ) -RRB- cord-010092-uftc8inx 2649 37 . . . cord-010092-uftc8inx 2650 1 Until until IN cord-010092-uftc8inx 2650 2 , , , cord-010092-uftc8inx 2650 3 in in IN cord-010092-uftc8inx 2650 4 2011 2011 CD cord-010092-uftc8inx 2650 5 , , , cord-010092-uftc8inx 2650 6 we -PRON- PRP cord-010092-uftc8inx 2650 7 found find VBD cord-010092-uftc8inx 2650 8 that that IN cord-010092-uftc8inx 2650 9 sex sex NN cord-010092-uftc8inx 2650 10 - - HYPH cord-010092-uftc8inx 2650 11 mismatched mismatch VBN cord-010092-uftc8inx 2650 12 red red JJ cord-010092-uftc8inx 2650 13 blood blood NN cord-010092-uftc8inx 2650 14 cell cell NN cord-010092-uftc8inx 2650 15 transfusions transfusion NNS cord-010092-uftc8inx 2650 16 were be VBD cord-010092-uftc8inx 2650 17 associated associate VBN cord-010092-uftc8inx 2650 18 with with IN cord-010092-uftc8inx 2650 19 increased increase VBN cord-010092-uftc8inx 2650 20 recipient recipient NN cord-010092-uftc8inx 2650 21 mortality mortality NN cord-010092-uftc8inx 2650 22 . . . cord-010092-uftc8inx 2651 1 Since since IN cord-010092-uftc8inx 2651 2 then then RB cord-010092-uftc8inx 2651 3 , , , cord-010092-uftc8inx 2651 4 several several JJ cord-010092-uftc8inx 2651 5 other other JJ cord-010092-uftc8inx 2651 6 studies study NNS cord-010092-uftc8inx 2651 7 have have VBP cord-010092-uftc8inx 2651 8 confirmed confirm VBN cord-010092-uftc8inx 2651 9 these these DT cord-010092-uftc8inx 2651 10 findings finding NNS cord-010092-uftc8inx 2651 11 , , , cord-010092-uftc8inx 2651 12 but but CC cord-010092-uftc8inx 2651 13 some some DT cord-010092-uftc8inx 2651 14 studies study NNS cord-010092-uftc8inx 2651 15 also also RB cord-010092-uftc8inx 2651 16 did do VBD cord-010092-uftc8inx 2651 17 not not RB cord-010092-uftc8inx 2651 18 find find VB cord-010092-uftc8inx 2651 19 an an DT cord-010092-uftc8inx 2651 20 association association NN cord-010092-uftc8inx 2651 21 . . . cord-010092-uftc8inx 2652 1 All all DT cord-010092-uftc8inx 2652 2 of of IN cord-010092-uftc8inx 2652 3 these these DT cord-010092-uftc8inx 2652 4 studies study NNS cord-010092-uftc8inx 2652 5 relied rely VBD cord-010092-uftc8inx 2652 6 on on IN cord-010092-uftc8inx 2652 7 the the DT cord-010092-uftc8inx 2652 8 analyses analysis NNS cord-010092-uftc8inx 2652 9 of of IN cord-010092-uftc8inx 2652 10 routinely routinely RB cord-010092-uftc8inx 2652 11 collected collect VBN cord-010092-uftc8inx 2652 12 health health NN cord-010092-uftc8inx 2652 13 care care NN cord-010092-uftc8inx 2652 14 data datum NNS cord-010092-uftc8inx 2652 15 , , , cord-010092-uftc8inx 2652 16 which which WDT cord-010092-uftc8inx 2652 17 was be VBD cord-010092-uftc8inx 2652 18 not not RB cord-010092-uftc8inx 2652 19 primarily primarily RB cord-010092-uftc8inx 2652 20 intended intend VBN cord-010092-uftc8inx 2652 21 to to TO cord-010092-uftc8inx 2652 22 be be VB cord-010092-uftc8inx 2652 23 used use VBN cord-010092-uftc8inx 2652 24 for for IN cord-010092-uftc8inx 2652 25 research research NN cord-010092-uftc8inx 2652 26 . . . cord-010092-uftc8inx 2653 1 As as IN cord-010092-uftc8inx 2653 2 a a DT cord-010092-uftc8inx 2653 3 result result NN cord-010092-uftc8inx 2653 4 , , , cord-010092-uftc8inx 2653 5 analyses analysis NNS cord-010092-uftc8inx 2653 6 are be VBP cord-010092-uftc8inx 2653 7 complex complex JJ cord-010092-uftc8inx 2653 8 and and CC cord-010092-uftc8inx 2653 9 often often RB cord-010092-uftc8inx 2653 10 difficult difficult JJ cord-010092-uftc8inx 2653 11 to to TO cord-010092-uftc8inx 2653 12 properly properly RB cord-010092-uftc8inx 2653 13 appraise appraise VB cord-010092-uftc8inx 2653 14 based base VBN cord-010092-uftc8inx 2653 15 on on IN cord-010092-uftc8inx 2653 16 published publish VBN cord-010092-uftc8inx 2653 17 descriptions description NNS cord-010092-uftc8inx 2653 18 . . . cord-010092-uftc8inx 2654 1 Therefore therefore RB cord-010092-uftc8inx 2654 2 , , , cord-010092-uftc8inx 2654 3 the the DT cord-010092-uftc8inx 2654 4 discussion discussion NN cord-010092-uftc8inx 2654 5 about about IN cord-010092-uftc8inx 2654 6 possible possible JJ cord-010092-uftc8inx 2654 7 reasons reason NNS cord-010092-uftc8inx 2654 8 for for IN cord-010092-uftc8inx 2654 9 these these DT cord-010092-uftc8inx 2654 10 discordant discordant JJ cord-010092-uftc8inx 2654 11 findings finding NNS cord-010092-uftc8inx 2654 12 has have VBZ cord-010092-uftc8inx 2654 13 largely largely RB cord-010092-uftc8inx 2654 14 focused focus VBN cord-010092-uftc8inx 2654 15 on on IN cord-010092-uftc8inx 2654 16 the the DT cord-010092-uftc8inx 2654 17 methodological methodological JJ cord-010092-uftc8inx 2654 18 approaches approach NNS cord-010092-uftc8inx 2654 19 of of IN cord-010092-uftc8inx 2654 20 the the DT cord-010092-uftc8inx 2654 21 different different JJ cord-010092-uftc8inx 2654 22 studies study NNS cord-010092-uftc8inx 2654 23 . . . cord-010092-uftc8inx 2655 1 Other other JJ cord-010092-uftc8inx 2655 2 potential potential JJ cord-010092-uftc8inx 2655 3 explanations explanation NNS cord-010092-uftc8inx 2655 4 include include VBP cord-010092-uftc8inx 2655 5 differences difference NNS cord-010092-uftc8inx 2655 6 in in IN cord-010092-uftc8inx 2655 7 donor donor NN cord-010092-uftc8inx 2655 8 or or CC cord-010092-uftc8inx 2655 9 patient patient JJ cord-010092-uftc8inx 2655 10 populations population NNS cord-010092-uftc8inx 2655 11 , , , cord-010092-uftc8inx 2655 12 production production NN cord-010092-uftc8inx 2655 13 methods method NNS cord-010092-uftc8inx 2655 14 , , , cord-010092-uftc8inx 2655 15 or or CC cord-010092-uftc8inx 2655 16 storage storage NN cord-010092-uftc8inx 2655 17 time time NN cord-010092-uftc8inx 2655 18 of of IN cord-010092-uftc8inx 2655 19 blood blood NN cord-010092-uftc8inx 2655 20 products product NNS cord-010092-uftc8inx 2655 21 . . . cord-010092-uftc8inx 2656 1 The the DT cord-010092-uftc8inx 2656 2 different different JJ cord-010092-uftc8inx 2656 3 potential potential JJ cord-010092-uftc8inx 2656 4 explanations explanation NNS cord-010092-uftc8inx 2656 5 are be VBP cord-010092-uftc8inx 2656 6 expected expect VBN cord-010092-uftc8inx 2656 7 to to TO cord-010092-uftc8inx 2656 8 be be VB cord-010092-uftc8inx 2656 9 associated associate VBN cord-010092-uftc8inx 2656 10 with with IN cord-010092-uftc8inx 2656 11 different different JJ cord-010092-uftc8inx 2656 12 underlying underlying JJ cord-010092-uftc8inx 2656 13 biological biological JJ cord-010092-uftc8inx 2656 14 mechanisms mechanism NNS cord-010092-uftc8inx 2656 15 . . . cord-010092-uftc8inx 2657 1 Therefore therefore RB cord-010092-uftc8inx 2657 2 , , , cord-010092-uftc8inx 2657 3 further further RB cord-010092-uftc8inx 2657 4 delineating delineate VBG cord-010092-uftc8inx 2657 5 which which WDT cord-010092-uftc8inx 2657 6 donor donor NN cord-010092-uftc8inx 2657 7 , , , cord-010092-uftc8inx 2657 8 patient patient NN cord-010092-uftc8inx 2657 9 , , , cord-010092-uftc8inx 2657 10 and and CC cord-010092-uftc8inx 2657 11 product product NN cord-010092-uftc8inx 2657 12 characteristics characteristic NNS cord-010092-uftc8inx 2657 13 modify modify VBP cord-010092-uftc8inx 2657 14 the the DT cord-010092-uftc8inx 2657 15 observed observed JJ cord-010092-uftc8inx 2657 16 association association NN cord-010092-uftc8inx 2657 17 could could MD cord-010092-uftc8inx 2657 18 provide provide VB cord-010092-uftc8inx 2657 19 more more JJR cord-010092-uftc8inx 2657 20 insight insight NN cord-010092-uftc8inx 2657 21 into into IN cord-010092-uftc8inx 2657 22 the the DT cord-010092-uftc8inx 2657 23 underlying underlying JJ cord-010092-uftc8inx 2657 24 mechanism mechanism NN cord-010092-uftc8inx 2657 25 . . . cord-010092-uftc8inx 2658 1 In in IN cord-010092-uftc8inx 2658 2 2017 2017 CD cord-010092-uftc8inx 2658 3 , , , cord-010092-uftc8inx 2658 4 we -PRON- PRP cord-010092-uftc8inx 2658 5 observed observe VBD cord-010092-uftc8inx 2658 6 that that IN cord-010092-uftc8inx 2658 7 only only JJ cord-010092-uftc8inx 2658 8 transfusions transfusion NNS cord-010092-uftc8inx 2658 9 from from IN cord-010092-uftc8inx 2658 10 female female JJ cord-010092-uftc8inx 2658 11 donors donor NNS cord-010092-uftc8inx 2658 12 with with IN cord-010092-uftc8inx 2658 13 previous previous JJ cord-010092-uftc8inx 2658 14 pregnancies pregnancy NNS cord-010092-uftc8inx 2658 15 were be VBD cord-010092-uftc8inx 2658 16 associated associate VBN cord-010092-uftc8inx 2658 17 with with IN cord-010092-uftc8inx 2658 18 increased increase VBN cord-010092-uftc8inx 2658 19 mortality mortality NN cord-010092-uftc8inx 2658 20 and and CC cord-010092-uftc8inx 2658 21 only only RB cord-010092-uftc8inx 2658 22 in in IN cord-010092-uftc8inx 2658 23 male male JJ cord-010092-uftc8inx 2658 24 recipients recipient NNS cord-010092-uftc8inx 2658 25 under under IN cord-010092-uftc8inx 2658 26 50 50 CD cord-010092-uftc8inx 2658 27 years year NNS cord-010092-uftc8inx 2658 28 . . . cord-010092-uftc8inx 2659 1 This this DT cord-010092-uftc8inx 2659 2 leads lead VBZ cord-010092-uftc8inx 2659 3 us -PRON- PRP cord-010092-uftc8inx 2659 4 to to TO cord-010092-uftc8inx 2659 5 postulate postulate VB cord-010092-uftc8inx 2659 6 that that DT cord-010092-uftc8inx 2659 7 pregnancy pregnancy NN cord-010092-uftc8inx 2659 8 induced induce VBN cord-010092-uftc8inx 2659 9 long long JJ cord-010092-uftc8inx 2659 10 term term NN cord-010092-uftc8inx 2659 11 changes change NNS cord-010092-uftc8inx 2659 12 in in IN cord-010092-uftc8inx 2659 13 the the DT cord-010092-uftc8inx 2659 14 female female JJ cord-010092-uftc8inx 2659 15 immune immune JJ cord-010092-uftc8inx 2659 16 system system NN cord-010092-uftc8inx 2659 17 are be VBP cord-010092-uftc8inx 2659 18 transferred transfer VBN cord-010092-uftc8inx 2659 19 during during IN cord-010092-uftc8inx 2659 20 red red JJ cord-010092-uftc8inx 2659 21 cell cell NN cord-010092-uftc8inx 2659 22 transfusion transfusion NN cord-010092-uftc8inx 2659 23 , , , cord-010092-uftc8inx 2659 24 with with IN cord-010092-uftc8inx 2659 25 negative negative JJ cord-010092-uftc8inx 2659 26 consequences consequence NNS cord-010092-uftc8inx 2659 27 for for IN cord-010092-uftc8inx 2659 28 young young JJ cord-010092-uftc8inx 2659 29 male male JJ cord-010092-uftc8inx 2659 30 recipients recipient NNS cord-010092-uftc8inx 2659 31 . . . cord-010092-uftc8inx 2660 1 The the DT cord-010092-uftc8inx 2660 2 low low JJ cord-010092-uftc8inx 2660 3 amount amount NN cord-010092-uftc8inx 2660 4 of of IN cord-010092-uftc8inx 2660 5 plasma plasma NN cord-010092-uftc8inx 2660 6 present present NN cord-010092-uftc8inx 2660 7 in in IN cord-010092-uftc8inx 2660 8 red red JJ cord-010092-uftc8inx 2660 9 cell cell NN cord-010092-uftc8inx 2660 10 products product NNS cord-010092-uftc8inx 2660 11 further further RB cord-010092-uftc8inx 2660 12 lead lead VBP cord-010092-uftc8inx 2660 13 us -PRON- PRP cord-010092-uftc8inx 2660 14 to to TO cord-010092-uftc8inx 2660 15 assume assume VB cord-010092-uftc8inx 2660 16 a a DT cord-010092-uftc8inx 2660 17 cellular cellular JJ cord-010092-uftc8inx 2660 18 component component NN cord-010092-uftc8inx 2660 19 , , , cord-010092-uftc8inx 2660 20 like like IN cord-010092-uftc8inx 2660 21 passenger passenger NN cord-010092-uftc8inx 2660 22 leukocytes leukocyte NNS cord-010092-uftc8inx 2660 23 , , , cord-010092-uftc8inx 2660 24 to to TO cord-010092-uftc8inx 2660 25 be be VB cord-010092-uftc8inx 2660 26 involved involve VBN cord-010092-uftc8inx 2660 27 . . . cord-010092-uftc8inx 2661 1 It -PRON- PRP cord-010092-uftc8inx 2661 2 has have VBZ cord-010092-uftc8inx 2661 3 been be VBN cord-010092-uftc8inx 2661 4 shown show VBN cord-010092-uftc8inx 2661 5 that that IN cord-010092-uftc8inx 2661 6 micro micro NN cord-010092-uftc8inx 2661 7 - - NN cord-010092-uftc8inx 2661 8 chimerism chimerism NN cord-010092-uftc8inx 2661 9 of of IN cord-010092-uftc8inx 2661 10 passenger passenger NN cord-010092-uftc8inx 2661 11 leukocytes leukocyte NNS cord-010092-uftc8inx 2661 12 can can MD cord-010092-uftc8inx 2661 13 persist persist VB cord-010092-uftc8inx 2661 14 for for IN cord-010092-uftc8inx 2661 15 decades decade NNS cord-010092-uftc8inx 2661 16 after after IN cord-010092-uftc8inx 2661 17 transfusion transfusion NN cord-010092-uftc8inx 2661 18 , , , cord-010092-uftc8inx 2661 19 even even RB cord-010092-uftc8inx 2661 20 of of IN cord-010092-uftc8inx 2661 21 leuko leuko NN cord-010092-uftc8inx 2661 22 - - HYPH cord-010092-uftc8inx 2661 23 reduced reduce VBN cord-010092-uftc8inx 2661 24 blood blood NN cord-010092-uftc8inx 2661 25 products product NNS cord-010092-uftc8inx 2661 26 , , , cord-010092-uftc8inx 2661 27 suggesting suggest VBG cord-010092-uftc8inx 2661 28 long long JJ cord-010092-uftc8inx 2661 29 term term NN cord-010092-uftc8inx 2661 30 immune immune JJ cord-010092-uftc8inx 2661 31 - - HYPH cord-010092-uftc8inx 2661 32 modulation modulation NN cord-010092-uftc8inx 2661 33 could could MD cord-010092-uftc8inx 2661 34 play play VB cord-010092-uftc8inx 2661 35 a a DT cord-010092-uftc8inx 2661 36 role role NN cord-010092-uftc8inx 2661 37 . . . cord-010092-uftc8inx 2662 1 We -PRON- PRP cord-010092-uftc8inx 2662 2 hypothesized hypothesize VBD cord-010092-uftc8inx 2662 3 that that IN cord-010092-uftc8inx 2662 4 passenger passenger NN cord-010092-uftc8inx 2662 5 leukocytes leukocyte NNS cord-010092-uftc8inx 2662 6 would would MD cord-010092-uftc8inx 2662 7 die die VB cord-010092-uftc8inx 2662 8 during during IN cord-010092-uftc8inx 2662 9 storage storage NN cord-010092-uftc8inx 2662 10 of of IN cord-010092-uftc8inx 2662 11 blood blood NN cord-010092-uftc8inx 2662 12 products product NNS cord-010092-uftc8inx 2662 13 and and CC cord-010092-uftc8inx 2662 14 the the DT cord-010092-uftc8inx 2662 15 negative negative JJ cord-010092-uftc8inx 2662 16 effect effect NN cord-010092-uftc8inx 2662 17 of of IN cord-010092-uftc8inx 2662 18 ever ever RB cord-010092-uftc8inx 2662 19 - - HYPH cord-010092-uftc8inx 2662 20 pregnant pregnant JJ cord-010092-uftc8inx 2662 21 female female JJ cord-010092-uftc8inx 2662 22 donors donor NNS cord-010092-uftc8inx 2662 23 , , , cord-010092-uftc8inx 2662 24 on on IN cord-010092-uftc8inx 2662 25 the the DT cord-010092-uftc8inx 2662 26 survival survival NN cord-010092-uftc8inx 2662 27 of of IN cord-010092-uftc8inx 2662 28 young young JJ cord-010092-uftc8inx 2662 29 male male JJ cord-010092-uftc8inx 2662 30 red red JJ cord-010092-uftc8inx 2662 31 cell cell NN cord-010092-uftc8inx 2662 32 recipients recipient NNS cord-010092-uftc8inx 2662 33 , , , cord-010092-uftc8inx 2662 34 would would MD cord-010092-uftc8inx 2662 35 therefore therefore RB cord-010092-uftc8inx 2662 36 be be VB cord-010092-uftc8inx 2662 37 attenuated attenuate VBN cord-010092-uftc8inx 2662 38 by by IN cord-010092-uftc8inx 2662 39 increased increase VBN cord-010092-uftc8inx 2662 40 storage storage NN cord-010092-uftc8inx 2662 41 time time NN cord-010092-uftc8inx 2662 42 . . . cord-010092-uftc8inx 2663 1 However however RB cord-010092-uftc8inx 2663 2 , , , cord-010092-uftc8inx 2663 3 our -PRON- PRP$ cord-010092-uftc8inx 2663 4 data datum NNS cord-010092-uftc8inx 2663 5 seem seem VBP cord-010092-uftc8inx 2663 6 to to TO cord-010092-uftc8inx 2663 7 indicate indicate VB cord-010092-uftc8inx 2663 8 the the DT cord-010092-uftc8inx 2663 9 opposite opposite NN cord-010092-uftc8inx 2663 10 . . . cord-010092-uftc8inx 2664 1 The the DT cord-010092-uftc8inx 2664 2 risk risk NN cord-010092-uftc8inx 2664 3 of of IN cord-010092-uftc8inx 2664 4 death death NN cord-010092-uftc8inx 2664 5 was be VBD cord-010092-uftc8inx 2664 6 increased increase VBN cord-010092-uftc8inx 2664 7 over over IN cord-010092-uftc8inx 2664 8 three three CD cord-010092-uftc8inx 2664 9 - - HYPH cord-010092-uftc8inx 2664 10 fold fold NN cord-010092-uftc8inx 2664 11 for for IN cord-010092-uftc8inx 2664 12 young young JJ cord-010092-uftc8inx 2664 13 male male JJ cord-010092-uftc8inx 2664 14 recipients recipient NNS cord-010092-uftc8inx 2664 15 of of IN cord-010092-uftc8inx 2664 16 old old JJ cord-010092-uftc8inx 2664 17 ( ( -LRB- cord-010092-uftc8inx 2664 18 > > NFP cord-010092-uftc8inx 2664 19 24 24 CD cord-010092-uftc8inx 2664 20 days day NNS cord-010092-uftc8inx 2664 21 storage storage NN cord-010092-uftc8inx 2664 22 ) ) -RRB- cord-010092-uftc8inx 2664 23 red red JJ cord-010092-uftc8inx 2664 24 cells cell NNS cord-010092-uftc8inx 2664 25 from from IN cord-010092-uftc8inx 2664 26 ever ever RB cord-010092-uftc8inx 2664 27 - - HYPH cord-010092-uftc8inx 2664 28 pregnant pregnant JJ cord-010092-uftc8inx 2664 29 donors donor NNS cord-010092-uftc8inx 2664 30 , , , cord-010092-uftc8inx 2664 31 compared compare VBN cord-010092-uftc8inx 2664 32 to to IN cord-010092-uftc8inx 2664 33 for for IN cord-010092-uftc8inx 2664 34 young young JJ cord-010092-uftc8inx 2664 35 male male JJ cord-010092-uftc8inx 2664 36 recipients recipient NNS cord-010092-uftc8inx 2664 37 of of IN cord-010092-uftc8inx 2664 38 fresh fresh JJ cord-010092-uftc8inx 2664 39 ( ( -LRB- cord-010092-uftc8inx 2664 40 < < NNP cord-010092-uftc8inx 2664 41 10 10 CD cord-010092-uftc8inx 2664 42 days day NNS cord-010092-uftc8inx 2664 43 storage storage NN cord-010092-uftc8inx 2664 44 ) ) -RRB- cord-010092-uftc8inx 2664 45 red red JJ cord-010092-uftc8inx 2664 46 cells cell NNS cord-010092-uftc8inx 2664 47 from from IN cord-010092-uftc8inx 2664 48 ever ever RB cord-010092-uftc8inx 2664 49 - - HYPH cord-010092-uftc8inx 2664 50 pregnant pregnant JJ cord-010092-uftc8inx 2664 51 donors donor NNS cord-010092-uftc8inx 2664 52 ( ( -LRB- cord-010092-uftc8inx 2664 53 3-year 3-year CD cord-010092-uftc8inx 2664 54 cumulative cumulative JJ cord-010092-uftc8inx 2664 55 incidence incidence NN cord-010092-uftc8inx 2664 56 of of IN cord-010092-uftc8inx 2664 57 death death NN cord-010092-uftc8inx 2664 58 15.4 15.4 CD cord-010092-uftc8inx 2664 59 % % NN cord-010092-uftc8inx 2664 60 versus versus IN cord-010092-uftc8inx 2664 61 4.8 4.8 CD cord-010092-uftc8inx 2664 62 % % NN cord-010092-uftc8inx 2664 63 ) ) -RRB- cord-010092-uftc8inx 2664 64 . . . cord-010092-uftc8inx 2665 1 The the DT cord-010092-uftc8inx 2665 2 negative negative JJ cord-010092-uftc8inx 2665 3 control control NN cord-010092-uftc8inx 2665 4 group group NN cord-010092-uftc8inx 2665 5 ( ( -LRB- cord-010092-uftc8inx 2665 6 i.e. i.e. FW cord-010092-uftc8inx 2665 7 young young JJ cord-010092-uftc8inx 2665 8 male male JJ cord-010092-uftc8inx 2665 9 recipients recipient NNS cord-010092-uftc8inx 2665 10 of of IN cord-010092-uftc8inx 2665 11 red red JJ cord-010092-uftc8inx 2665 12 cells cell NNS cord-010092-uftc8inx 2665 13 from from IN cord-010092-uftc8inx 2665 14 male male JJ cord-010092-uftc8inx 2665 15 donors donor NNS cord-010092-uftc8inx 2665 16 ) ) -RRB- cord-010092-uftc8inx 2665 17 showed show VBD cord-010092-uftc8inx 2665 18 a a DT cord-010092-uftc8inx 2665 19 much much RB cord-010092-uftc8inx 2665 20 weaker weak JJR cord-010092-uftc8inx 2665 21 association association NN cord-010092-uftc8inx 2665 22 of of IN cord-010092-uftc8inx 2665 23 mortality mortality NN cord-010092-uftc8inx 2665 24 with with IN cord-010092-uftc8inx 2665 25 storage storage NN cord-010092-uftc8inx 2665 26 time time NN cord-010092-uftc8inx 2665 27 ( ( -LRB- cord-010092-uftc8inx 2665 28 i.e. i.e. FW cord-010092-uftc8inx 2665 29 7.2 7.2 CD cord-010092-uftc8inx 2665 30 % % NN cord-010092-uftc8inx 2665 31 versus versus IN cord-010092-uftc8inx 2665 32 4.7 4.7 CD cord-010092-uftc8inx 2665 33 % % NN cord-010092-uftc8inx 2665 34 ) ) -RRB- cord-010092-uftc8inx 2665 35 . . . cord-010092-uftc8inx 2666 1 These these DT cord-010092-uftc8inx 2666 2 findings finding NNS cord-010092-uftc8inx 2666 3 seem seem VBP cord-010092-uftc8inx 2666 4 to to TO cord-010092-uftc8inx 2666 5 falsify falsify VB cord-010092-uftc8inx 2666 6 our -PRON- PRP$ cord-010092-uftc8inx 2666 7 hypothesis hypothesis NN cord-010092-uftc8inx 2666 8 that that IN cord-010092-uftc8inx 2666 9 mortality mortality NN cord-010092-uftc8inx 2666 10 could could MD cord-010092-uftc8inx 2666 11 be be VB cord-010092-uftc8inx 2666 12 caused cause VBN cord-010092-uftc8inx 2666 13 by by IN cord-010092-uftc8inx 2666 14 passenger passenger NN cord-010092-uftc8inx 2666 15 leukocytes leukocyte NNS cord-010092-uftc8inx 2666 16 , , , cord-010092-uftc8inx 2666 17 establishing establish VBG cord-010092-uftc8inx 2666 18 long long JJ cord-010092-uftc8inx 2666 19 term term NN cord-010092-uftc8inx 2666 20 immune immune JJ cord-010092-uftc8inx 2666 21 - - HYPH cord-010092-uftc8inx 2666 22 modulatory modulatory JJ cord-010092-uftc8inx 2666 23 effects effect NNS cord-010092-uftc8inx 2666 24 . . . cord-010092-uftc8inx 2667 1 Another another DT cord-010092-uftc8inx 2667 2 potential potential JJ cord-010092-uftc8inx 2667 3 mechanism mechanism NN cord-010092-uftc8inx 2667 4 that that WDT cord-010092-uftc8inx 2667 5 has have VBZ cord-010092-uftc8inx 2667 6 been be VBN cord-010092-uftc8inx 2667 7 suggested suggest VBN cord-010092-uftc8inx 2667 8 could could MD cord-010092-uftc8inx 2667 9 be be VB cord-010092-uftc8inx 2667 10 the the DT cord-010092-uftc8inx 2667 11 presence presence NN cord-010092-uftc8inx 2667 12 of of IN cord-010092-uftc8inx 2667 13 cellfree cellfree NNP cord-010092-uftc8inx 2667 14 DNA DNA NNP cord-010092-uftc8inx 2667 15 in in IN cord-010092-uftc8inx 2667 16 transfused transfuse VBN cord-010092-uftc8inx 2667 17 blood blood NN cord-010092-uftc8inx 2667 18 products product NNS cord-010092-uftc8inx 2667 19 . . . cord-010092-uftc8inx 2668 1 This this DT cord-010092-uftc8inx 2668 2 cell cell NN cord-010092-uftc8inx 2668 3 - - HYPH cord-010092-uftc8inx 2668 4 free free JJ cord-010092-uftc8inx 2668 5 DNA dna NN cord-010092-uftc8inx 2668 6 increases increase NNS cord-010092-uftc8inx 2668 7 during during IN cord-010092-uftc8inx 2668 8 storage storage NN cord-010092-uftc8inx 2668 9 . . . cord-010092-uftc8inx 2669 1 However however RB cord-010092-uftc8inx 2669 2 , , , cord-010092-uftc8inx 2669 3 more more JJR cord-010092-uftc8inx 2669 4 research research NN cord-010092-uftc8inx 2669 5 is be VBZ cord-010092-uftc8inx 2669 6 needed need VBN cord-010092-uftc8inx 2669 7 both both DT cord-010092-uftc8inx 2669 8 to to TO cord-010092-uftc8inx 2669 9 establish establish VB cord-010092-uftc8inx 2669 10 if if IN cord-010092-uftc8inx 2669 11 cell cell NN cord-010092-uftc8inx 2669 12 - - HYPH cord-010092-uftc8inx 2669 13 free free JJ cord-010092-uftc8inx 2669 14 DNA dna NN cord-010092-uftc8inx 2669 15 can can MD cord-010092-uftc8inx 2669 16 also also RB cord-010092-uftc8inx 2669 17 be be VB cord-010092-uftc8inx 2669 18 linked link VBN cord-010092-uftc8inx 2669 19 to to IN cord-010092-uftc8inx 2669 20 previously previously RB cord-010092-uftc8inx 2669 21 pregnant pregnant JJ cord-010092-uftc8inx 2669 22 blood blood NN cord-010092-uftc8inx 2669 23 donors donor NNS cord-010092-uftc8inx 2669 24 and and CC cord-010092-uftc8inx 2669 25 by by IN cord-010092-uftc8inx 2669 26 which which WDT cord-010092-uftc8inx 2669 27 mechanism mechanism NN cord-010092-uftc8inx 2669 28 it -PRON- PRP cord-010092-uftc8inx 2669 29 could could MD cord-010092-uftc8inx 2669 30 negatively negatively RB cord-010092-uftc8inx 2669 31 affect affect VB cord-010092-uftc8inx 2669 32 young young JJ cord-010092-uftc8inx 2669 33 male male JJ cord-010092-uftc8inx 2669 34 transfusion transfusion NN cord-010092-uftc8inx 2669 35 recipients recipient NNS cord-010092-uftc8inx 2669 36 . . . cord-010092-uftc8inx 2670 1 Clinical clinical JJ cord-010092-uftc8inx 2670 2 trials trial NNS cord-010092-uftc8inx 2670 3 ( ( -LRB- cord-010092-uftc8inx 2670 4 CTs CTs NNP cord-010092-uftc8inx 2670 5 ) ) -RRB- cord-010092-uftc8inx 2670 6 , , , cord-010092-uftc8inx 2670 7 the the DT cord-010092-uftc8inx 2670 8 gems gem NNS cord-010092-uftc8inx 2670 9 in in IN cord-010092-uftc8inx 2670 10 clinical clinical JJ cord-010092-uftc8inx 2670 11 research research NN cord-010092-uftc8inx 2670 12 for for IN cord-010092-uftc8inx 2670 13 generating generate VBG cord-010092-uftc8inx 2670 14 robust robust JJ cord-010092-uftc8inx 2670 15 evidence evidence NN cord-010092-uftc8inx 2670 16 in in IN cord-010092-uftc8inx 2670 17 medicine medicine NN cord-010092-uftc8inx 2670 18 and and CC cord-010092-uftc8inx 2670 19 public public JJ cord-010092-uftc8inx 2670 20 health health NN cord-010092-uftc8inx 2670 21 , , , cord-010092-uftc8inx 2670 22 are be VBP cord-010092-uftc8inx 2670 23 costly costly JJ cord-010092-uftc8inx 2670 24 and and CC cord-010092-uftc8inx 2670 25 complicated complicated JJ cord-010092-uftc8inx 2670 26 undertakings undertaking NNS cord-010092-uftc8inx 2670 27 . . . cord-010092-uftc8inx 2671 1 In in IN cord-010092-uftc8inx 2671 2 resource resource NN cord-010092-uftc8inx 2671 3 limited limit VBN cord-010092-uftc8inx 2671 4 setting setting NN cord-010092-uftc8inx 2671 5 like like IN cord-010092-uftc8inx 2671 6 sub sub JJ cord-010092-uftc8inx 2671 7 - - JJ cord-010092-uftc8inx 2671 8 Saharan saharan JJ cord-010092-uftc8inx 2671 9 Africa Africa NNP cord-010092-uftc8inx 2671 10 ( ( -LRB- cord-010092-uftc8inx 2671 11 SSA SSA NNP cord-010092-uftc8inx 2671 12 ) ) -RRB- cord-010092-uftc8inx 2671 13 where where WRB cord-010092-uftc8inx 2671 14 the the DT cord-010092-uftc8inx 2671 15 health health NN cord-010092-uftc8inx 2671 16 systems system NNS cord-010092-uftc8inx 2671 17 are be VBP cord-010092-uftc8inx 2671 18 sub sub NN cord-010092-uftc8inx 2671 19 - - JJ cord-010092-uftc8inx 2671 20 optimal optimal JJ cord-010092-uftc8inx 2671 21 and and CC cord-010092-uftc8inx 2671 22 where where WRB cord-010092-uftc8inx 2671 23 capacity capacity NN cord-010092-uftc8inx 2671 24 for for IN cord-010092-uftc8inx 2671 25 research research NN cord-010092-uftc8inx 2671 26 is be VBZ cord-010092-uftc8inx 2671 27 limited limit VBN cord-010092-uftc8inx 2671 28 , , , cord-010092-uftc8inx 2671 29 the the DT cord-010092-uftc8inx 2671 30 conducting conducting NN cord-010092-uftc8inx 2671 31 of of IN cord-010092-uftc8inx 2671 32 CTs ct NNS cord-010092-uftc8inx 2671 33 can can MD cord-010092-uftc8inx 2671 34 be be VB cord-010092-uftc8inx 2671 35 a a DT cord-010092-uftc8inx 2671 36 daunting daunting JJ cord-010092-uftc8inx 2671 37 challenge challenge NN cord-010092-uftc8inx 2671 38 . . . cord-010092-uftc8inx 2672 1 The the DT cord-010092-uftc8inx 2672 2 challenges challenge NNS cord-010092-uftc8inx 2672 3 of of IN cord-010092-uftc8inx 2672 4 undertaking undertake VBG cord-010092-uftc8inx 2672 5 CTs ct NNS cord-010092-uftc8inx 2672 6 in in IN cord-010092-uftc8inx 2672 7 RLs RLs NNP cord-010092-uftc8inx 2672 8 may may MD cord-010092-uftc8inx 2672 9 be be VB cord-010092-uftc8inx 2672 10 categorized categorize VBN cord-010092-uftc8inx 2672 11 based base VBN cord-010092-uftc8inx 2672 12 on on IN cord-010092-uftc8inx 2672 13 the the DT cord-010092-uftc8inx 2672 14 occurrence occurrence NN cord-010092-uftc8inx 2672 15 of of IN cord-010092-uftc8inx 2672 16 the the DT cord-010092-uftc8inx 2672 17 bottleneck(s bottleneck(s NNP cord-010092-uftc8inx 2672 18 ) ) -RRB- cord-010092-uftc8inx 2672 19 in in IN cord-010092-uftc8inx 2672 20 relation relation NN cord-010092-uftc8inx 2672 21 to to IN cord-010092-uftc8inx 2672 22 the the DT cord-010092-uftc8inx 2672 23 ethics ethic NNS cord-010092-uftc8inx 2672 24 and and CC cord-010092-uftc8inx 2672 25 regulatory regulatory JJ cord-010092-uftc8inx 2672 26 approval approval NN cord-010092-uftc8inx 2672 27 process process NN cord-010092-uftc8inx 2672 28 : : : cord-010092-uftc8inx 2673 1 Pre pre JJ cord-010092-uftc8inx 2673 2 - - JJ cord-010092-uftc8inx 2673 3 approval approval NN cord-010092-uftc8inx 2673 4 : : : cord-010092-uftc8inx 2673 5 Protocol Protocol NNP cord-010092-uftc8inx 2673 6 Development Development NNP cord-010092-uftc8inx 2673 7 : : : cord-010092-uftc8inx 2673 8 In in IN cord-010092-uftc8inx 2673 9 order order NN cord-010092-uftc8inx 2673 10 to to TO cord-010092-uftc8inx 2673 11 develop develop VB cord-010092-uftc8inx 2673 12 a a DT cord-010092-uftc8inx 2673 13 context context NN cord-010092-uftc8inx 2673 14 - - HYPH cord-010092-uftc8inx 2673 15 specific specific JJ cord-010092-uftc8inx 2673 16 protocol protocol NN cord-010092-uftc8inx 2673 17 which which WDT cord-010092-uftc8inx 2673 18 is be VBZ cord-010092-uftc8inx 2673 19 subsequently subsequently RB cord-010092-uftc8inx 2673 20 subjected subject VBN cord-010092-uftc8inx 2673 21 to to IN cord-010092-uftc8inx 2673 22 an an DT cord-010092-uftc8inx 2673 23 ethics ethic NNS cord-010092-uftc8inx 2673 24 and and CC cord-010092-uftc8inx 2673 25 regulatory regulatory JJ cord-010092-uftc8inx 2673 26 approval approval NN cord-010092-uftc8inx 2673 27 process process NN cord-010092-uftc8inx 2673 28 , , , cord-010092-uftc8inx 2673 29 investigators investigator NNS cord-010092-uftc8inx 2673 30 need need VBP cord-010092-uftc8inx 2673 31 to to TO cord-010092-uftc8inx 2673 32 review review VB cord-010092-uftc8inx 2673 33 and and CC cord-010092-uftc8inx 2673 34 ensure ensure VB cord-010092-uftc8inx 2673 35 that that IN cord-010092-uftc8inx 2673 36 the the DT cord-010092-uftc8inx 2673 37 protocol protocol NN cord-010092-uftc8inx 2673 38 is be VBZ cord-010092-uftc8inx 2673 39 pragmatic pragmatic JJ cord-010092-uftc8inx 2673 40 and and CC cord-010092-uftc8inx 2673 41 feasible feasible JJ cord-010092-uftc8inx 2673 42 with with IN cord-010092-uftc8inx 2673 43 respect respect NN cord-010092-uftc8inx 2673 44 to to IN cord-010092-uftc8inx 2673 45 implementation implementation NN cord-010092-uftc8inx 2673 46 . . . cord-010092-uftc8inx 2674 1 This this DT cord-010092-uftc8inx 2674 2 results result VBZ cord-010092-uftc8inx 2674 3 into into IN cord-010092-uftc8inx 2674 4 a a DT cord-010092-uftc8inx 2674 5 time time NN cord-010092-uftc8inx 2674 6 - - HYPH cord-010092-uftc8inx 2674 7 consuming consume VBG cord-010092-uftc8inx 2674 8 reiterative reiterative JJ cord-010092-uftc8inx 2674 9 process process NN cord-010092-uftc8inx 2674 10 of of IN cord-010092-uftc8inx 2674 11 reality reality NN cord-010092-uftc8inx 2674 12 - - HYPH cord-010092-uftc8inx 2674 13 checking check VBG cord-010092-uftc8inx 2674 14 the the DT cord-010092-uftc8inx 2674 15 protocol protocol NN cord-010092-uftc8inx 2674 16 . . . cord-010092-uftc8inx 2675 1 Site site NN cord-010092-uftc8inx 2675 2 Selection selection NN cord-010092-uftc8inx 2675 3 : : : cord-010092-uftc8inx 2675 4 In in IN cord-010092-uftc8inx 2675 5 light light NN cord-010092-uftc8inx 2675 6 of of IN cord-010092-uftc8inx 2675 7 the the DT cord-010092-uftc8inx 2675 8 limited limited JJ cord-010092-uftc8inx 2675 9 research research NN cord-010092-uftc8inx 2675 10 infrastructure infrastructure NN cord-010092-uftc8inx 2675 11 , , , cord-010092-uftc8inx 2675 12 investigators investigator NNS cord-010092-uftc8inx 2675 13 in in IN cord-010092-uftc8inx 2675 14 RLS RLS NNP cord-010092-uftc8inx 2675 15 and and CC cord-010092-uftc8inx 2675 16 their -PRON- PRP$ cord-010092-uftc8inx 2675 17 developed develop VBN cord-010092-uftc8inx 2675 18 world world NN cord-010092-uftc8inx 2675 19 partners partner NNS cord-010092-uftc8inx 2675 20 spend spend VBP cord-010092-uftc8inx 2675 21 considerable considerable JJ cord-010092-uftc8inx 2675 22 time time NN cord-010092-uftc8inx 2675 23 reviewing review VBG cord-010092-uftc8inx 2675 24 and and CC cord-010092-uftc8inx 2675 25 selecting select VBG cord-010092-uftc8inx 2675 26 suitable suitable JJ cord-010092-uftc8inx 2675 27 sites site NNS cord-010092-uftc8inx 2675 28 for for IN cord-010092-uftc8inx 2675 29 participation participation NN cord-010092-uftc8inx 2675 30 in in IN cord-010092-uftc8inx 2675 31 the the DT cord-010092-uftc8inx 2675 32 anticipated anticipate VBN cord-010092-uftc8inx 2675 33 protocol protocol NN cord-010092-uftc8inx 2675 34 for for IN cord-010092-uftc8inx 2675 35 the the DT cord-010092-uftc8inx 2675 36 CTs ct NNS cord-010092-uftc8inx 2675 37 . . . cord-010092-uftc8inx 2676 1 Suitable suitable JJ cord-010092-uftc8inx 2676 2 sites site NNS cord-010092-uftc8inx 2676 3 are be VBP cord-010092-uftc8inx 2676 4 usually usually RB cord-010092-uftc8inx 2676 5 very very RB cord-010092-uftc8inx 2676 6 few few JJ cord-010092-uftc8inx 2676 7 and and CC cord-010092-uftc8inx 2676 8 with with IN cord-010092-uftc8inx 2676 9 competing compete VBG cord-010092-uftc8inx 2676 10 on on IN cord-010092-uftc8inx 2676 11 - - HYPH cord-010092-uftc8inx 2676 12 going go VBG cord-010092-uftc8inx 2676 13 studies study NNS cord-010092-uftc8inx 2676 14 . . . cord-010092-uftc8inx 2677 1 Approval approval NN cord-010092-uftc8inx 2677 2 : : : cord-010092-uftc8inx 2678 1 Institutional Institutional NNP cord-010092-uftc8inx 2678 2 Review Review NNP cord-010092-uftc8inx 2678 3 Board Board NNP cord-010092-uftc8inx 2678 4 ( ( -LRB- cord-010092-uftc8inx 2678 5 IRB IRB NNP cord-010092-uftc8inx 2678 6 ) ) -RRB- cord-010092-uftc8inx 2678 7 approval approval NN cord-010092-uftc8inx 2678 8 : : : cord-010092-uftc8inx 2679 1 The the DT cord-010092-uftc8inx 2679 2 IRB IRB NNP cord-010092-uftc8inx 2679 3 approval approval NN cord-010092-uftc8inx 2679 4 process process NN cord-010092-uftc8inx 2679 5 can can MD cord-010092-uftc8inx 2679 6 be be VB cord-010092-uftc8inx 2679 7 quite quite RB cord-010092-uftc8inx 2679 8 lengthy lengthy JJ cord-010092-uftc8inx 2679 9 ( ( -LRB- cord-010092-uftc8inx 2679 10 6 6 CD cord-010092-uftc8inx 2679 11 - - SYM cord-010092-uftc8inx 2679 12 9 9 CD cord-010092-uftc8inx 2679 13 months month NNS cord-010092-uftc8inx 2679 14 ) ) -RRB- cord-010092-uftc8inx 2679 15 with with IN cord-010092-uftc8inx 2679 16 considerable considerable JJ cord-010092-uftc8inx 2679 17 unpredictability unpredictability NN cord-010092-uftc8inx 2679 18 in in IN cord-010092-uftc8inx 2679 19 the the DT cord-010092-uftc8inx 2679 20 periods period NNS cord-010092-uftc8inx 2679 21 between between IN cord-010092-uftc8inx 2679 22 the the DT cord-010092-uftc8inx 2679 23 initial initial JJ cord-010092-uftc8inx 2679 24 and and CC cord-010092-uftc8inx 2679 25 subsequent subsequent JJ cord-010092-uftc8inx 2679 26 IRB IRB NNP cord-010092-uftc8inx 2679 27 reviews review NNS cord-010092-uftc8inx 2679 28 . . . cord-010092-uftc8inx 2680 1 National national JJ cord-010092-uftc8inx 2680 2 regulatory regulatory JJ cord-010092-uftc8inx 2680 3 approval approval NN cord-010092-uftc8inx 2680 4 : : : cord-010092-uftc8inx 2681 1 The the DT cord-010092-uftc8inx 2681 2 requirements requirement NNS cord-010092-uftc8inx 2681 3 by by IN cord-010092-uftc8inx 2681 4 national national JJ cord-010092-uftc8inx 2681 5 regulators regulator NNS cord-010092-uftc8inx 2681 6 are be VBP cord-010092-uftc8inx 2681 7 unusually unusually RB cord-010092-uftc8inx 2681 8 innumerable innumerable JJ cord-010092-uftc8inx 2681 9 with with IN cord-010092-uftc8inx 2681 10 limited limited JJ cord-010092-uftc8inx 2681 11 flexibility flexibility NN cord-010092-uftc8inx 2681 12 to to TO cord-010092-uftc8inx 2681 13 accommodate accommodate VB cord-010092-uftc8inx 2681 14 specific specific JJ cord-010092-uftc8inx 2681 15 CTs ct NNS cord-010092-uftc8inx 2681 16 . . . cord-010092-uftc8inx 2682 1 Post post NN cord-010092-uftc8inx 2682 2 - - NN cord-010092-uftc8inx 2682 3 approval approval NN cord-010092-uftc8inx 2682 4 : : : cord-010092-uftc8inx 2683 1 The the DT cord-010092-uftc8inx 2683 2 key key JJ cord-010092-uftc8inx 2683 3 post post JJ cord-010092-uftc8inx 2683 4 - - JJ cord-010092-uftc8inx 2683 5 approval approval JJ cord-010092-uftc8inx 2683 6 challenges challenge NNS cord-010092-uftc8inx 2683 7 for for IN cord-010092-uftc8inx 2683 8 CTs cts JJ cord-010092-uftc8inx 2683 9 implementation implementation NN cord-010092-uftc8inx 2683 10 in in IN cord-010092-uftc8inx 2683 11 RLS RLS NNP cord-010092-uftc8inx 2683 12 are be VBP cord-010092-uftc8inx 2683 13 attaining attain VBG cord-010092-uftc8inx 2683 14 appropriate appropriate JJ cord-010092-uftc8inx 2683 15 participant participant NN cord-010092-uftc8inx 2683 16 enrolment enrolment NN cord-010092-uftc8inx 2683 17 and and CC cord-010092-uftc8inx 2683 18 maintaining maintain VBG cord-010092-uftc8inx 2683 19 high high JJ cord-010092-uftc8inx 2683 20 retention retention NN cord-010092-uftc8inx 2683 21 rates rate NNS cord-010092-uftc8inx 2683 22 . . . cord-010092-uftc8inx 2684 1 Specifically specifically RB cord-010092-uftc8inx 2684 2 , , , cord-010092-uftc8inx 2684 3 for for IN cord-010092-uftc8inx 2684 4 participant participant NN cord-010092-uftc8inx 2684 5 enrollment enrollment NN cord-010092-uftc8inx 2684 6 , , , cord-010092-uftc8inx 2684 7 the the DT cord-010092-uftc8inx 2684 8 challenge challenge NN cord-010092-uftc8inx 2684 9 may may MD cord-010092-uftc8inx 2684 10 be be VB cord-010092-uftc8inx 2684 11 unforeseen unforeseen JJ cord-010092-uftc8inx 2684 12 competing compete VBG cord-010092-uftc8inx 2684 13 CTs ct NNS cord-010092-uftc8inx 2684 14 targeting target VBG cord-010092-uftc8inx 2684 15 the the DT cord-010092-uftc8inx 2684 16 same same JJ cord-010092-uftc8inx 2684 17 participant participant NN cord-010092-uftc8inx 2684 18 pool pool NN cord-010092-uftc8inx 2684 19 or or CC cord-010092-uftc8inx 2684 20 community community NN cord-010092-uftc8inx 2684 21 perspectives perspective NNS cord-010092-uftc8inx 2684 22 that that WDT cord-010092-uftc8inx 2684 23 may may MD cord-010092-uftc8inx 2684 24 discourage discourage VB cord-010092-uftc8inx 2684 25 participants participant NNS cord-010092-uftc8inx 2684 26 from from IN cord-010092-uftc8inx 2684 27 getting get VBG cord-010092-uftc8inx 2684 28 screened screen VBN cord-010092-uftc8inx 2684 29 for for IN cord-010092-uftc8inx 2684 30 the the DT cord-010092-uftc8inx 2684 31 CTs ct NNS cord-010092-uftc8inx 2684 32 . . . cord-010092-uftc8inx 2685 1 Retention Retention NNP cord-010092-uftc8inx 2685 2 may may MD cord-010092-uftc8inx 2685 3 also also RB cord-010092-uftc8inx 2685 4 be be VB cord-010092-uftc8inx 2685 5 a a DT cord-010092-uftc8inx 2685 6 challenge challenge NN cord-010092-uftc8inx 2685 7 particularly particularly RB cord-010092-uftc8inx 2685 8 where where WRB cord-010092-uftc8inx 2685 9 participants participant NNS cord-010092-uftc8inx 2685 10 view view VBP cord-010092-uftc8inx 2685 11 enrollment enrollment NN cord-010092-uftc8inx 2685 12 as as IN cord-010092-uftc8inx 2685 13 a a DT cord-010092-uftc8inx 2685 14 chance chance NN cord-010092-uftc8inx 2685 15 to to TO cord-010092-uftc8inx 2685 16 access access VB cord-010092-uftc8inx 2685 17 healthcare healthcare NN cord-010092-uftc8inx 2685 18 services service NNS cord-010092-uftc8inx 2685 19 may may MD cord-010092-uftc8inx 2685 20 therefore therefore RB cord-010092-uftc8inx 2685 21 not not RB cord-010092-uftc8inx 2685 22 have have VB cord-010092-uftc8inx 2685 23 any any DT cord-010092-uftc8inx 2685 24 incentive incentive NN cord-010092-uftc8inx 2685 25 to to TO cord-010092-uftc8inx 2685 26 keep keep VB cord-010092-uftc8inx 2685 27 in in IN cord-010092-uftc8inx 2685 28 a a DT cord-010092-uftc8inx 2685 29 study study NN cord-010092-uftc8inx 2685 30 after after IN cord-010092-uftc8inx 2685 31 the the DT cord-010092-uftc8inx 2685 32 initial initial JJ cord-010092-uftc8inx 2685 33 study study NN cord-010092-uftc8inx 2685 34 visits visit NNS cord-010092-uftc8inx 2685 35 . . . cord-010092-uftc8inx 2686 1 In in IN cord-010092-uftc8inx 2686 2 conclusion conclusion NN cord-010092-uftc8inx 2686 3 , , , cord-010092-uftc8inx 2686 4 CTS CTS NNP cord-010092-uftc8inx 2686 5 are be VBP cord-010092-uftc8inx 2686 6 complex complex JJ cord-010092-uftc8inx 2686 7 undertakings undertaking NNS cord-010092-uftc8inx 2686 8 wherever wherever WRB cord-010092-uftc8inx 2686 9 they -PRON- PRP cord-010092-uftc8inx 2686 10 are be VBP cord-010092-uftc8inx 2686 11 conducted conduct VBN cord-010092-uftc8inx 2686 12 but but CC cord-010092-uftc8inx 2686 13 are be VBP cord-010092-uftc8inx 2686 14 doubly doubly RB cord-010092-uftc8inx 2686 15 challenging challenging JJ cord-010092-uftc8inx 2686 16 in in IN cord-010092-uftc8inx 2686 17 RLS RLS NNP cord-010092-uftc8inx 2686 18 like like IN cord-010092-uftc8inx 2686 19 sub sub JJ cord-010092-uftc8inx 2686 20 - - JJ cord-010092-uftc8inx 2686 21 Saharan saharan JJ cord-010092-uftc8inx 2686 22 Africa Africa NNP cord-010092-uftc8inx 2686 23 . . . cord-010092-uftc8inx 2687 1 The the DT cord-010092-uftc8inx 2687 2 bottlenecks bottleneck NNS cord-010092-uftc8inx 2687 3 at at IN cord-010092-uftc8inx 2687 4 the the DT cord-010092-uftc8inx 2687 5 preapproval preapproval NN cord-010092-uftc8inx 2687 6 , , , cord-010092-uftc8inx 2687 7 approval approval NN cord-010092-uftc8inx 2687 8 and and CC cord-010092-uftc8inx 2687 9 post post JJ cord-010092-uftc8inx 2687 10 - - JJ cord-010092-uftc8inx 2687 11 approval approval JJ cord-010092-uftc8inx 2687 12 stages stage NNS cord-010092-uftc8inx 2687 13 are be VBP cord-010092-uftc8inx 2687 14 considerable considerable JJ cord-010092-uftc8inx 2687 15 . . . cord-010092-uftc8inx 2688 1 Nevertheless nevertheless RB cord-010092-uftc8inx 2688 2 , , , cord-010092-uftc8inx 2688 3 it -PRON- PRP cord-010092-uftc8inx 2688 4 is be VBZ cord-010092-uftc8inx 2688 5 rewarding rewarding JJ cord-010092-uftc8inx 2688 6 to to TO cord-010092-uftc8inx 2688 7 perform perform VB cord-010092-uftc8inx 2688 8 CTUs ctu NNS cord-010092-uftc8inx 2688 9 in in IN cord-010092-uftc8inx 2688 10 RLS RLS NNP cord-010092-uftc8inx 2688 11 given give VBN cord-010092-uftc8inx 2688 12 that that IN cord-010092-uftc8inx 2688 13 the the DT cord-010092-uftc8inx 2688 14 data datum NNS cord-010092-uftc8inx 2688 15 generated generate VBN cord-010092-uftc8inx 2688 16 therein therein RB cord-010092-uftc8inx 2688 17 is be VBZ cord-010092-uftc8inx 2688 18 highly highly RB cord-010092-uftc8inx 2688 19 valued value VBN cord-010092-uftc8inx 2688 20 by by IN cord-010092-uftc8inx 2688 21 national national JJ cord-010092-uftc8inx 2688 22 regulators regulator NNS cord-010092-uftc8inx 2688 23 and and CC cord-010092-uftc8inx 2688 24 may may MD cord-010092-uftc8inx 2688 25 hasten hasten VB cord-010092-uftc8inx 2688 26 the the DT cord-010092-uftc8inx 2688 27 registration registration NN cord-010092-uftc8inx 2688 28 process process NN cord-010092-uftc8inx 2688 29 for for IN cord-010092-uftc8inx 2688 30 medical medical JJ cord-010092-uftc8inx 2688 31 products product NNS cord-010092-uftc8inx 2688 32 . . . cord-010092-uftc8inx 2689 1 Background background NN cord-010092-uftc8inx 2689 2 : : : cord-010092-uftc8inx 2690 1 Interest interest NN cord-010092-uftc8inx 2690 2 in in IN cord-010092-uftc8inx 2690 3 an an DT cord-010092-uftc8inx 2690 4 appropriate appropriate JJ cord-010092-uftc8inx 2690 5 and and CC cord-010092-uftc8inx 2690 6 effective effective JJ cord-010092-uftc8inx 2690 7 whole whole JJ cord-010092-uftc8inx 2690 8 blood blood NN cord-010092-uftc8inx 2690 9 ( ( -LRB- cord-010092-uftc8inx 2690 10 WB WB NNP cord-010092-uftc8inx 2690 11 ) ) -RRB- cord-010092-uftc8inx 2690 12 pathogen pathogen NN cord-010092-uftc8inx 2690 13 reduction reduction NN cord-010092-uftc8inx 2690 14 technology technology NN cord-010092-uftc8inx 2690 15 ( ( -LRB- cord-010092-uftc8inx 2690 16 PRT PRT NNP cord-010092-uftc8inx 2690 17 ) ) -RRB- cord-010092-uftc8inx 2690 18 is be VBZ cord-010092-uftc8inx 2690 19 growing grow VBG cord-010092-uftc8inx 2690 20 , , , cord-010092-uftc8inx 2690 21 especially especially RB cord-010092-uftc8inx 2690 22 in in IN cord-010092-uftc8inx 2690 23 sub sub JJ cord-010092-uftc8inx 2690 24 - - JJ cord-010092-uftc8inx 2690 25 Saharan Saharan NNP cord-010092-uftc8inx 2690 26 Africa Africa NNP cord-010092-uftc8inx 2690 27 where where WRB cord-010092-uftc8inx 2690 28 the the DT cord-010092-uftc8inx 2690 29 residual residual JJ cord-010092-uftc8inx 2690 30 risk risk NN cord-010092-uftc8inx 2690 31 of of IN cord-010092-uftc8inx 2690 32 transfusion transfusion NN cord-010092-uftc8inx 2690 33 - - HYPH cord-010092-uftc8inx 2690 34 transmitted transmit VBN cord-010092-uftc8inx 2690 35 infections infection NNS cord-010092-uftc8inx 2690 36 ( ( -LRB- cord-010092-uftc8inx 2690 37 TTIs tti NNS cord-010092-uftc8inx 2690 38 ) ) -RRB- cord-010092-uftc8inx 2690 39 remains remain VBZ cord-010092-uftc8inx 2690 40 unacceptably unacceptably RB cord-010092-uftc8inx 2690 41 high high JJ cord-010092-uftc8inx 2690 42 and and CC cord-010092-uftc8inx 2690 43 WB WB NNP cord-010092-uftc8inx 2690 44 is be VBZ cord-010092-uftc8inx 2690 45 still still RB cord-010092-uftc8inx 2690 46 frequently frequently RB cord-010092-uftc8inx 2690 47 used use VBN cord-010092-uftc8inx 2690 48 . . . cord-010092-uftc8inx 2691 1 Cerus Cerus NNP cord-010092-uftc8inx 2691 2 Corporation Corporation NNP cord-010092-uftc8inx 2691 3 , , , cord-010092-uftc8inx 2691 4 manufacturer manufacturer NN cord-010092-uftc8inx 2691 5 of of IN cord-010092-uftc8inx 2691 6 the the DT cord-010092-uftc8inx 2691 7 INTERCEPT INTERCEPT NNP cord-010092-uftc8inx 2691 8 TM TM NNP cord-010092-uftc8inx 2691 9 Blood Blood NNP cord-010092-uftc8inx 2691 10 System System NNP cord-010092-uftc8inx 2691 11 , , , cord-010092-uftc8inx 2691 12 and and CC cord-010092-uftc8inx 2691 13 Swiss Swiss NNP cord-010092-uftc8inx 2691 14 Transfusion Transfusion NNP cord-010092-uftc8inx 2691 15 SRC SRC NNP cord-010092-uftc8inx 2691 16 are be VBP cord-010092-uftc8inx 2691 17 collaborating collaborate VBG cord-010092-uftc8inx 2691 18 on on IN cord-010092-uftc8inx 2691 19 a a DT cord-010092-uftc8inx 2691 20 clinical clinical JJ cord-010092-uftc8inx 2691 21 development development NN cord-010092-uftc8inx 2691 22 program program NN cord-010092-uftc8inx 2691 23 to to TO cord-010092-uftc8inx 2691 24 adapt adapt VB cord-010092-uftc8inx 2691 25 INTERCEPT INTERCEPT NNP cord-010092-uftc8inx 2691 26 PRT PRT NNP cord-010092-uftc8inx 2691 27 using use VBG cord-010092-uftc8inx 2691 28 amustaline amustaline NNP cord-010092-uftc8inx 2691 29 ( ( -LRB- cord-010092-uftc8inx 2691 30 S-303 s-303 NN cord-010092-uftc8inx 2691 31 ) ) -RRB- cord-010092-uftc8inx 2691 32 and and CC cord-010092-uftc8inx 2691 33 glutathione glutathione NN cord-010092-uftc8inx 2691 34 ( ( -LRB- cord-010092-uftc8inx 2691 35 GSH GSH NNP cord-010092-uftc8inx 2691 36 ) ) -RRB- cord-010092-uftc8inx 2691 37 for for IN cord-010092-uftc8inx 2691 38 red red JJ cord-010092-uftc8inx 2691 39 blood blood NN cord-010092-uftc8inx 2691 40 cells cell NNS cord-010092-uftc8inx 2691 41 ( ( -LRB- cord-010092-uftc8inx 2691 42 RBCs rbc NNS cord-010092-uftc8inx 2691 43 ) ) -RRB- cord-010092-uftc8inx 2691 44 into into IN cord-010092-uftc8inx 2691 45 an an DT cord-010092-uftc8inx 2691 46 appropriate appropriate JJ cord-010092-uftc8inx 2691 47 PRT PRT NNP cord-010092-uftc8inx 2691 48 for for IN cord-010092-uftc8inx 2691 49 WB WB NNP cord-010092-uftc8inx 2691 50 in in IN cord-010092-uftc8inx 2691 51 resource resource NN cord-010092-uftc8inx 2691 52 - - HYPH cord-010092-uftc8inx 2691 53 limited limit VBN cord-010092-uftc8inx 2691 54 settings setting NNS cord-010092-uftc8inx 2691 55 in in IN cord-010092-uftc8inx 2691 56 Africa Africa NNP cord-010092-uftc8inx 2691 57 . . . cord-010092-uftc8inx 2692 1 Treatment treatment NN cord-010092-uftc8inx 2692 2 with with IN cord-010092-uftc8inx 2692 3 amustaline amustaline NN cord-010092-uftc8inx 2692 4 / / SYM cord-010092-uftc8inx 2692 5 GSH GSH NNP cord-010092-uftc8inx 2692 6 has have VBZ cord-010092-uftc8inx 2692 7 been be VBN cord-010092-uftc8inx 2692 8 shown show VBN cord-010092-uftc8inx 2692 9 to to TO cord-010092-uftc8inx 2692 10 inactivate inactivate VB cord-010092-uftc8inx 2692 11 a a DT cord-010092-uftc8inx 2692 12 broad broad JJ cord-010092-uftc8inx 2692 13 spectrum spectrum NN cord-010092-uftc8inx 2692 14 of of IN cord-010092-uftc8inx 2692 15 transfusion transfusion NN cord-010092-uftc8inx 2692 16 - - HYPH cord-010092-uftc8inx 2692 17 transmissible transmissible JJ cord-010092-uftc8inx 2692 18 pathogens pathogen NNS cord-010092-uftc8inx 2692 19 in in IN cord-010092-uftc8inx 2692 20 RBCs rbc NNS cord-010092-uftc8inx 2692 21 . . . cord-010092-uftc8inx 2693 1 Studies study NNS cord-010092-uftc8inx 2693 2 with with IN cord-010092-uftc8inx 2693 3 amustaline amustaline NN cord-010092-uftc8inx 2693 4 / / SYM cord-010092-uftc8inx 2693 5 GSH GSH NNP cord-010092-uftc8inx 2693 6 in in IN cord-010092-uftc8inx 2693 7 WB WB NNP cord-010092-uftc8inx 2693 8 have have VBP cord-010092-uftc8inx 2693 9 shown show VBN cord-010092-uftc8inx 2693 10 effectiveness effectiveness NN cord-010092-uftc8inx 2693 11 against against IN cord-010092-uftc8inx 2693 12 a a DT cord-010092-uftc8inx 2693 13 duck duck NN cord-010092-uftc8inx 2693 14 hepatitis hepatitis NN cord-010092-uftc8inx 2693 15 B b NN cord-010092-uftc8inx 2693 16 virus virus NN cord-010092-uftc8inx 2693 17 ( ( -LRB- cord-010092-uftc8inx 2693 18 > > NFP cord-010092-uftc8inx 2693 19 5.3 5.3 CD cord-010092-uftc8inx 2693 20 log log NN cord-010092-uftc8inx 2693 21 reduction reduction NN cord-010092-uftc8inx 2693 22 ) ) -RRB- cord-010092-uftc8inx 2693 23 and and CC cord-010092-uftc8inx 2693 24 Plasmodium Plasmodium NNP cord-010092-uftc8inx 2693 25 falciparum falciparum NN cord-010092-uftc8inx 2693 26 ( ( -LRB- cord-010092-uftc8inx 2693 27 > > NFP cord-010092-uftc8inx 2693 28 7.5 7.5 CD cord-010092-uftc8inx 2693 29 log log NN cord-010092-uftc8inx 2693 30 reduction reduction NN cord-010092-uftc8inx 2693 31 ) ) -RRB- cord-010092-uftc8inx 2693 32 , , , cord-010092-uftc8inx 2693 33 with with IN cord-010092-uftc8inx 2693 34 future future JJ cord-010092-uftc8inx 2693 35 studies study NNS cord-010092-uftc8inx 2693 36 planned plan VBN cord-010092-uftc8inx 2693 37 . . . cord-010092-uftc8inx 2694 1 A a DT cord-010092-uftc8inx 2694 2 WB WB NNP cord-010092-uftc8inx 2694 3 PRT PRT NNP cord-010092-uftc8inx 2694 4 system system NN cord-010092-uftc8inx 2694 5 with with IN cord-010092-uftc8inx 2694 6 amustaline amustaline NNP cord-010092-uftc8inx 2694 7 / / SYM cord-010092-uftc8inx 2694 8 GSH GSH NNP cord-010092-uftc8inx 2694 9 also also RB cord-010092-uftc8inx 2694 10 has have VBZ cord-010092-uftc8inx 2694 11 the the DT cord-010092-uftc8inx 2694 12 potential potential JJ cord-010092-uftc8inx 2694 13 benefit benefit NN cord-010092-uftc8inx 2694 14 of of IN cord-010092-uftc8inx 2694 15 minimal minimal JJ cord-010092-uftc8inx 2694 16 electricity electricity NN cord-010092-uftc8inx 2694 17 requirements requirement NNS cord-010092-uftc8inx 2694 18 . . . cord-010092-uftc8inx 2695 1 Aims aim VBZ cord-010092-uftc8inx 2695 2 : : : cord-010092-uftc8inx 2695 3 To to TO cord-010092-uftc8inx 2695 4 describe describe VB cord-010092-uftc8inx 2695 5 the the DT cord-010092-uftc8inx 2695 6 safety safety NN cord-010092-uftc8inx 2695 7 and and CC cord-010092-uftc8inx 2695 8 clinical clinical JJ cord-010092-uftc8inx 2695 9 objectives objective NNS cord-010092-uftc8inx 2695 10 for for IN cord-010092-uftc8inx 2695 11 a a DT cord-010092-uftc8inx 2695 12 Phase phase NN cord-010092-uftc8inx 2695 13 1 1 CD cord-010092-uftc8inx 2695 14 clinical clinical JJ cord-010092-uftc8inx 2695 15 trial trial NN cord-010092-uftc8inx 2695 16 using use VBG cord-010092-uftc8inx 2695 17 the the DT cord-010092-uftc8inx 2695 18 amustaline amustaline NN cord-010092-uftc8inx 2695 19 / / SYM cord-010092-uftc8inx 2695 20 GSH GSH NNP cord-010092-uftc8inx 2695 21 PRT PRT NNP cord-010092-uftc8inx 2695 22 system system NN cord-010092-uftc8inx 2695 23 for for IN cord-010092-uftc8inx 2695 24 WB WB NNP cord-010092-uftc8inx 2695 25 in in IN cord-010092-uftc8inx 2695 26 Africa Africa NNP cord-010092-uftc8inx 2695 27 , , , cord-010092-uftc8inx 2695 28 and and CC cord-010092-uftc8inx 2695 29 describe describe VB cord-010092-uftc8inx 2695 30 research research NN cord-010092-uftc8inx 2695 31 and and CC cord-010092-uftc8inx 2695 32 development development NN cord-010092-uftc8inx 2695 33 efforts effort NNS cord-010092-uftc8inx 2695 34 to to TO cord-010092-uftc8inx 2695 35 adapt adapt VB cord-010092-uftc8inx 2695 36 the the DT cord-010092-uftc8inx 2695 37 INTERCEPT INTERCEPT NNP cord-010092-uftc8inx 2695 38 PRT PRT NNP cord-010092-uftc8inx 2695 39 system system NN cord-010092-uftc8inx 2695 40 for for IN cord-010092-uftc8inx 2695 41 RBCs rbc NNS cord-010092-uftc8inx 2695 42 into into IN cord-010092-uftc8inx 2695 43 a a DT cord-010092-uftc8inx 2695 44 robust robust JJ cord-010092-uftc8inx 2695 45 and and CC cord-010092-uftc8inx 2695 46 appropriate appropriate JJ cord-010092-uftc8inx 2695 47 WB WB NNP cord-010092-uftc8inx 2695 48 system system NN cord-010092-uftc8inx 2695 49 for for IN cord-010092-uftc8inx 2695 50 settings setting NNS cord-010092-uftc8inx 2695 51 with with IN cord-010092-uftc8inx 2695 52 high high JJ cord-010092-uftc8inx 2695 53 burdens burden NNS cord-010092-uftc8inx 2695 54 of of IN cord-010092-uftc8inx 2695 55 TTI TTI NNP cord-010092-uftc8inx 2695 56 and and CC cord-010092-uftc8inx 2695 57 limited limited JJ cord-010092-uftc8inx 2695 58 resources resource NNS cord-010092-uftc8inx 2695 59 . . . cord-010092-uftc8inx 2696 1 Methods method NNS cord-010092-uftc8inx 2696 2 : : : cord-010092-uftc8inx 2697 1 The the DT cord-010092-uftc8inx 2697 2 protocol protocol NN cord-010092-uftc8inx 2697 3 for for IN cord-010092-uftc8inx 2697 4 a a DT cord-010092-uftc8inx 2697 5 Phase phase NN cord-010092-uftc8inx 2697 6 1 1 CD cord-010092-uftc8inx 2697 7 clinical clinical JJ cord-010092-uftc8inx 2697 8 trial trial NN cord-010092-uftc8inx 2697 9 using use VBG cord-010092-uftc8inx 2697 10 pathogen pathogen NN cord-010092-uftc8inx 2697 11 - - HYPH cord-010092-uftc8inx 2697 12 reduced reduce VBN cord-010092-uftc8inx 2697 13 WB WB NNP cord-010092-uftc8inx 2697 14 treated treat VBN cord-010092-uftc8inx 2697 15 with with IN cord-010092-uftc8inx 2697 16 amustaline amustaline NN cord-010092-uftc8inx 2697 17 / / SYM cord-010092-uftc8inx 2697 18 GSH GSH NNP cord-010092-uftc8inx 2697 19 in in IN cord-010092-uftc8inx 2697 20 an an DT cord-010092-uftc8inx 2697 21 African african JJ cord-010092-uftc8inx 2697 22 country country NN cord-010092-uftc8inx 2697 23 is be VBZ cord-010092-uftc8inx 2697 24 presented present VBN cord-010092-uftc8inx 2697 25 , , , cord-010092-uftc8inx 2697 26 as as IN cord-010092-uftc8inx 2697 27 are be VBP cord-010092-uftc8inx 2697 28 current current JJ cord-010092-uftc8inx 2697 29 research research NN cord-010092-uftc8inx 2697 30 and and CC cord-010092-uftc8inx 2697 31 development development NN cord-010092-uftc8inx 2697 32 activities activity NNS cord-010092-uftc8inx 2697 33 related relate VBN cord-010092-uftc8inx 2697 34 to to IN cord-010092-uftc8inx 2697 35 the the DT cord-010092-uftc8inx 2697 36 development development NN cord-010092-uftc8inx 2697 37 of of IN cord-010092-uftc8inx 2697 38 a a DT cord-010092-uftc8inx 2697 39 PRT PRT NNP cord-010092-uftc8inx 2697 40 system system NN cord-010092-uftc8inx 2697 41 for for IN cord-010092-uftc8inx 2697 42 WB WB NNP cord-010092-uftc8inx 2697 43 . . . cord-010092-uftc8inx 2698 1 Results result NNS cord-010092-uftc8inx 2698 2 : : : cord-010092-uftc8inx 2699 1 In in IN cord-010092-uftc8inx 2699 2 the the DT cord-010092-uftc8inx 2699 3 planned planned JJ cord-010092-uftc8inx 2699 4 Phase phase NN cord-010092-uftc8inx 2699 5 1 1 CD cord-010092-uftc8inx 2699 6 clinical clinical JJ cord-010092-uftc8inx 2699 7 trial trial NN cord-010092-uftc8inx 2699 8 in in IN cord-010092-uftc8inx 2699 9 Africa Africa NNP cord-010092-uftc8inx 2699 10 , , , cord-010092-uftc8inx 2699 11 20 20 CD cord-010092-uftc8inx 2699 12 clinically clinically RB cord-010092-uftc8inx 2699 13 stable stable JJ cord-010092-uftc8inx 2699 14 patients patient NNS cord-010092-uftc8inx 2699 15 with with IN cord-010092-uftc8inx 2699 16 anemia anemia NN cord-010092-uftc8inx 2699 17 who who WP cord-010092-uftc8inx 2699 18 require require VBP cord-010092-uftc8inx 2699 19 WB WB NNP cord-010092-uftc8inx 2699 20 transfusion transfusion NN cord-010092-uftc8inx 2699 21 will will MD cord-010092-uftc8inx 2699 22 be be VB cord-010092-uftc8inx 2699 23 randomized randomize VBN cord-010092-uftc8inx 2699 24 into into IN cord-010092-uftc8inx 2699 25 two two CD cord-010092-uftc8inx 2699 26 study study NN cord-010092-uftc8inx 2699 27 arms arm NNS cord-010092-uftc8inx 2699 28 at at IN cord-010092-uftc8inx 2699 29 a a DT cord-010092-uftc8inx 2699 30 large large JJ cord-010092-uftc8inx 2699 31 medical medical JJ cord-010092-uftc8inx 2699 32 center center NN cord-010092-uftc8inx 2699 33 in in IN cord-010092-uftc8inx 2699 34 a a DT cord-010092-uftc8inx 2699 35 sub sub JJ cord-010092-uftc8inx 2699 36 - - JJ cord-010092-uftc8inx 2699 37 Saharan saharan JJ cord-010092-uftc8inx 2699 38 African african JJ cord-010092-uftc8inx 2699 39 country country NN cord-010092-uftc8inx 2699 40 . . . cord-010092-uftc8inx 2700 1 Enrolled enrol VBN cord-010092-uftc8inx 2700 2 patients patient NNS cord-010092-uftc8inx 2700 3 will will MD cord-010092-uftc8inx 2700 4 receive receive VB cord-010092-uftc8inx 2700 5 one one CD cord-010092-uftc8inx 2700 6 unit unit NN cord-010092-uftc8inx 2700 7 of of IN cord-010092-uftc8inx 2700 8 non non JJ cord-010092-uftc8inx 2700 9 - - JJ cord-010092-uftc8inx 2700 10 leucocyte leucocyte RB cord-010092-uftc8inx 2700 11 - - HYPH cord-010092-uftc8inx 2700 12 reduced reduce VBN cord-010092-uftc8inx 2700 13 WB WB NNP cord-010092-uftc8inx 2700 14 treated treat VBN cord-010092-uftc8inx 2700 15 with with IN cord-010092-uftc8inx 2700 16 amustaline amustaline NN cord-010092-uftc8inx 2700 17 / / SYM cord-010092-uftc8inx 2700 18 GSH GSH NNP cord-010092-uftc8inx 2700 19 , , , cord-010092-uftc8inx 2700 20 or or CC cord-010092-uftc8inx 2700 21 a a DT cord-010092-uftc8inx 2700 22 unit unit NN cord-010092-uftc8inx 2700 23 of of IN cord-010092-uftc8inx 2700 24 untreated untreated JJ cord-010092-uftc8inx 2700 25 control control NN cord-010092-uftc8inx 2700 26 WB WB NNP cord-010092-uftc8inx 2700 27 or or CC cord-010092-uftc8inx 2700 28 RBCs rbc NNS cord-010092-uftc8inx 2700 29 . . . cord-010092-uftc8inx 2701 1 The the DT cord-010092-uftc8inx 2701 2 primary primary JJ cord-010092-uftc8inx 2701 3 safety safety NN cord-010092-uftc8inx 2701 4 endpoint endpoint NN cord-010092-uftc8inx 2701 5 will will MD cord-010092-uftc8inx 2701 6 be be VB cord-010092-uftc8inx 2701 7 the the DT cord-010092-uftc8inx 2701 8 incidence incidence NN cord-010092-uftc8inx 2701 9 of of IN cord-010092-uftc8inx 2701 10 high high JJ cord-010092-uftc8inx 2701 11 - - HYPH cord-010092-uftc8inx 2701 12 imputability imputability NN cord-010092-uftc8inx 2701 13 transfusion transfusion NN cord-010092-uftc8inx 2701 14 reactions reaction NNS cord-010092-uftc8inx 2701 15 ( ( -LRB- cord-010092-uftc8inx 2701 16 Swissmedic Swissmedic NNP cord-010092-uftc8inx 2701 17 ≥Grade ≥grade CD cord-010092-uftc8inx 2701 18 2 2 CD cord-010092-uftc8inx 2701 19 ) ) -RRB- cord-010092-uftc8inx 2701 20 within within IN cord-010092-uftc8inx 2701 21 the the DT cord-010092-uftc8inx 2701 22 first first JJ cord-010092-uftc8inx 2701 23 24 24 CD cord-010092-uftc8inx 2701 24 hours hour NNS cord-010092-uftc8inx 2701 25 of of IN cord-010092-uftc8inx 2701 26 transfusion transfusion NN cord-010092-uftc8inx 2701 27 . . . cord-010092-uftc8inx 2702 1 Data datum NNS cord-010092-uftc8inx 2702 2 will will MD cord-010092-uftc8inx 2702 3 also also RB cord-010092-uftc8inx 2702 4 be be VB cord-010092-uftc8inx 2702 5 collected collect VBN cord-010092-uftc8inx 2702 6 on on IN cord-010092-uftc8inx 2702 7 all all DT cord-010092-uftc8inx 2702 8 adverse adverse JJ cord-010092-uftc8inx 2702 9 events event NNS cord-010092-uftc8inx 2702 10 and and CC cord-010092-uftc8inx 2702 11 transfusion transfusion NN cord-010092-uftc8inx 2702 12 reactions reaction NNS cord-010092-uftc8inx 2702 13 ( ( -LRB- cord-010092-uftc8inx 2702 14 all all DT cord-010092-uftc8inx 2702 15 grades grade NNS cord-010092-uftc8inx 2702 16 ) ) -RRB- cord-010092-uftc8inx 2702 17 and and CC cord-010092-uftc8inx 2702 18 the the DT cord-010092-uftc8inx 2702 19 development development NN cord-010092-uftc8inx 2702 20 of of IN cord-010092-uftc8inx 2702 21 treatment treatment NN cord-010092-uftc8inx 2702 22 - - HYPH cord-010092-uftc8inx 2702 23 emergent emergent NN cord-010092-uftc8inx 2702 24 antibodies antibody NNS cord-010092-uftc8inx 2702 25 to to IN cord-010092-uftc8inx 2702 26 pathogen pathogen NN cord-010092-uftc8inx 2702 27 - - HYPH cord-010092-uftc8inx 2702 28 reduced reduce VBN cord-010092-uftc8inx 2702 29 WB WB NNP cord-010092-uftc8inx 2702 30 or or CC cord-010092-uftc8inx 2702 31 auto auto NN cord-010092-uftc8inx 2702 32 - - HYPH cord-010092-uftc8inx 2702 33 antibodies antibody NNS cord-010092-uftc8inx 2702 34 within within IN cord-010092-uftc8inx 2702 35 59 59 CD cord-010092-uftc8inx 2703 1 ( ( -LRB- cord-010092-uftc8inx 2703 2 AE3 AE3 NNS cord-010092-uftc8inx 2703 3 ) ) -RRB- cord-010092-uftc8inx 2703 4 days day NNS cord-010092-uftc8inx 2703 5 of of IN cord-010092-uftc8inx 2703 6 the the DT cord-010092-uftc8inx 2703 7 study study NN cord-010092-uftc8inx 2703 8 transfusion transfusion NN cord-010092-uftc8inx 2703 9 . . . cord-010092-uftc8inx 2704 1 Clinical clinical JJ cord-010092-uftc8inx 2704 2 efficacy efficacy NN cord-010092-uftc8inx 2704 3 will will MD cord-010092-uftc8inx 2704 4 be be VB cord-010092-uftc8inx 2704 5 characterized characterize VBN cord-010092-uftc8inx 2704 6 by by IN cord-010092-uftc8inx 2704 7 hemoglobin hemoglobin NN cord-010092-uftc8inx 2704 8 increment increment NN cord-010092-uftc8inx 2704 9 24 24 CD cord-010092-uftc8inx 2704 10 hours hour NNS cord-010092-uftc8inx 2704 11 after after IN cord-010092-uftc8inx 2704 12 transfusion transfusion NN cord-010092-uftc8inx 2704 13 adjusted adjust VBN cord-010092-uftc8inx 2704 14 to to IN cord-010092-uftc8inx 2704 15 hemoglobin hemoglobin NN cord-010092-uftc8inx 2704 16 dose dose NN cord-010092-uftc8inx 2704 17 and and CC cord-010092-uftc8inx 2704 18 body body NN cord-010092-uftc8inx 2704 19 weight weight NN cord-010092-uftc8inx 2704 20 . . . cord-010092-uftc8inx 2705 1 Summary Summary NNP cord-010092-uftc8inx 2705 2 / / SYM cord-010092-uftc8inx 2705 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 2705 4 : : : cord-010092-uftc8inx 2706 1 A a DT cord-010092-uftc8inx 2706 2 PRT PRT NNP cord-010092-uftc8inx 2706 3 system system NN cord-010092-uftc8inx 2706 4 for for IN cord-010092-uftc8inx 2706 5 WB WB NNP cord-010092-uftc8inx 2706 6 is be VBZ cord-010092-uftc8inx 2706 7 being be VBG cord-010092-uftc8inx 2706 8 developed develop VBN cord-010092-uftc8inx 2706 9 based base VBN cord-010092-uftc8inx 2706 10 on on IN cord-010092-uftc8inx 2706 11 the the DT cord-010092-uftc8inx 2706 12 INTERCEPT INTERCEPT NNP cord-010092-uftc8inx 2706 13 PRT PRT NNP cord-010092-uftc8inx 2706 14 for for IN cord-010092-uftc8inx 2706 15 RBCs rbc NNS cord-010092-uftc8inx 2706 16 that that WDT cord-010092-uftc8inx 2706 17 is be VBZ cord-010092-uftc8inx 2706 18 in in IN cord-010092-uftc8inx 2706 19 advanced advanced JJ cord-010092-uftc8inx 2706 20 development development NN cord-010092-uftc8inx 2706 21 in in IN cord-010092-uftc8inx 2706 22 Europe Europe NNP cord-010092-uftc8inx 2706 23 and and CC cord-010092-uftc8inx 2706 24 the the DT cord-010092-uftc8inx 2706 25 United United NNP cord-010092-uftc8inx 2706 26 States States NNP cord-010092-uftc8inx 2706 27 . . . cord-010092-uftc8inx 2707 1 INTERCEPT intercept VB cord-010092-uftc8inx 2707 2 - - HYPH cord-010092-uftc8inx 2707 3 treated treat VBN cord-010092-uftc8inx 2707 4 RBCs rbc NNS cord-010092-uftc8inx 2707 5 have have VBP cord-010092-uftc8inx 2707 6 met meet VBN cord-010092-uftc8inx 2707 7 efficacy efficacy NN cord-010092-uftc8inx 2707 8 and and CC cord-010092-uftc8inx 2707 9 safety safety NN cord-010092-uftc8inx 2707 10 endpoints endpoint NNS cord-010092-uftc8inx 2707 11 in in IN cord-010092-uftc8inx 2707 12 Phase phase NN cord-010092-uftc8inx 2707 13 3 3 CD cord-010092-uftc8inx 2707 14 clinical clinical JJ cord-010092-uftc8inx 2707 15 trials trial NNS cord-010092-uftc8inx 2707 16 . . . cord-010092-uftc8inx 2708 1 The the DT cord-010092-uftc8inx 2708 2 amustaline amustaline NN cord-010092-uftc8inx 2708 3 / / SYM cord-010092-uftc8inx 2708 4 GSH GSH NNP cord-010092-uftc8inx 2708 5 PRT PRT NNP cord-010092-uftc8inx 2708 6 system system NN cord-010092-uftc8inx 2708 7 used use VBD cord-010092-uftc8inx 2708 8 to to TO cord-010092-uftc8inx 2708 9 treat treat VB cord-010092-uftc8inx 2708 10 INTERCEPT INTERCEPT NNP cord-010092-uftc8inx 2708 11 RBCs rbc NNS cord-010092-uftc8inx 2708 12 has have VBZ cord-010092-uftc8inx 2708 13 demonstrated demonstrate VBN cord-010092-uftc8inx 2708 14 effective effective JJ cord-010092-uftc8inx 2708 15 inactivation inactivation NN cord-010092-uftc8inx 2708 16 against against IN cord-010092-uftc8inx 2708 17 a a DT cord-010092-uftc8inx 2708 18 broad broad JJ cord-010092-uftc8inx 2708 19 spectrum spectrum NN cord-010092-uftc8inx 2708 20 of of IN cord-010092-uftc8inx 2708 21 agents agent NNS cord-010092-uftc8inx 2708 22 that that WDT cord-010092-uftc8inx 2708 23 may may MD cord-010092-uftc8inx 2708 24 result result VB cord-010092-uftc8inx 2708 25 in in IN cord-010092-uftc8inx 2708 26 TTIs tti NNS cord-010092-uftc8inx 2708 27 . . . cord-010092-uftc8inx 2709 1 A a DT cord-010092-uftc8inx 2709 2 Phase phase NN cord-010092-uftc8inx 2709 3 1 1 CD cord-010092-uftc8inx 2709 4 clinical clinical JJ cord-010092-uftc8inx 2709 5 trial trial NN cord-010092-uftc8inx 2709 6 using use VBG cord-010092-uftc8inx 2709 7 an an DT cord-010092-uftc8inx 2709 8 adapted adapt VBN cord-010092-uftc8inx 2709 9 PRT PRT NNP cord-010092-uftc8inx 2709 10 system system NN cord-010092-uftc8inx 2709 11 for for IN cord-010092-uftc8inx 2709 12 WB WB NNP cord-010092-uftc8inx 2709 13 in in IN cord-010092-uftc8inx 2709 14 Africa Africa NNP cord-010092-uftc8inx 2709 15 is be VBZ cord-010092-uftc8inx 2709 16 the the DT cord-010092-uftc8inx 2709 17 first first JJ cord-010092-uftc8inx 2709 18 step step NN cord-010092-uftc8inx 2709 19 in in IN cord-010092-uftc8inx 2709 20 a a DT cord-010092-uftc8inx 2709 21 clinical clinical JJ cord-010092-uftc8inx 2709 22 development development NN cord-010092-uftc8inx 2709 23 program program NN cord-010092-uftc8inx 2709 24 that that WDT cord-010092-uftc8inx 2709 25 includes include VBZ cord-010092-uftc8inx 2709 26 additional additional JJ cord-010092-uftc8inx 2709 27 pathogen pathogen NN cord-010092-uftc8inx 2709 28 inactivation inactivation NN cord-010092-uftc8inx 2709 29 efficacy efficacy NN cord-010092-uftc8inx 2709 30 studies study NNS cord-010092-uftc8inx 2709 31 and and CC cord-010092-uftc8inx 2709 32 improvements improvement NNS cord-010092-uftc8inx 2709 33 to to IN cord-010092-uftc8inx 2709 34 the the DT cord-010092-uftc8inx 2709 35 WB WB NNP cord-010092-uftc8inx 2709 36 PRT PRT NNP cord-010092-uftc8inx 2709 37 implementation implementation NN cord-010092-uftc8inx 2709 38 process process NN cord-010092-uftc8inx 2709 39 . . . cord-010092-uftc8inx 2710 1 Together together RB cord-010092-uftc8inx 2710 2 , , , cord-010092-uftc8inx 2710 3 these these DT cord-010092-uftc8inx 2710 4 developments development NNS cord-010092-uftc8inx 2710 5 and and CC cord-010092-uftc8inx 2710 6 evaluations evaluation NNS cord-010092-uftc8inx 2710 7 represent represent VBP cord-010092-uftc8inx 2710 8 progress progress NN cord-010092-uftc8inx 2710 9 toward toward IN cord-010092-uftc8inx 2710 10 a a DT cord-010092-uftc8inx 2710 11 realistic realistic JJ cord-010092-uftc8inx 2710 12 and and CC cord-010092-uftc8inx 2710 13 appropriate appropriate JJ cord-010092-uftc8inx 2710 14 PRT PRT NNP cord-010092-uftc8inx 2710 15 for for IN cord-010092-uftc8inx 2710 16 WB WB NNP cord-010092-uftc8inx 2710 17 in in IN cord-010092-uftc8inx 2710 18 Africa Africa NNP cord-010092-uftc8inx 2710 19 and and CC cord-010092-uftc8inx 2710 20 other other JJ cord-010092-uftc8inx 2710 21 resource resource NN cord-010092-uftc8inx 2710 22 - - HYPH cord-010092-uftc8inx 2710 23 limited limit VBN cord-010092-uftc8inx 2710 24 settings setting NNS cord-010092-uftc8inx 2710 25 . . . cord-010092-uftc8inx 2711 1 Background background NN cord-010092-uftc8inx 2711 2 : : : cord-010092-uftc8inx 2712 1 In in IN cord-010092-uftc8inx 2712 2 Australia Australia NNP cord-010092-uftc8inx 2712 3 , , , cord-010092-uftc8inx 2712 4 demand demand NN cord-010092-uftc8inx 2712 5 for for IN cord-010092-uftc8inx 2712 6 plasma plasma NN cord-010092-uftc8inx 2712 7 - - HYPH cord-010092-uftc8inx 2712 8 derived derive VBN cord-010092-uftc8inx 2712 9 products product NNS cord-010092-uftc8inx 2712 10 has have VBZ cord-010092-uftc8inx 2712 11 increased increase VBN cord-010092-uftc8inx 2712 12 dramatically dramatically RB cord-010092-uftc8inx 2712 13 , , , cord-010092-uftc8inx 2712 14 and and CC cord-010092-uftc8inx 2712 15 there there EX cord-010092-uftc8inx 2712 16 is be VBZ cord-010092-uftc8inx 2712 17 a a DT cord-010092-uftc8inx 2712 18 need need NN cord-010092-uftc8inx 2712 19 to to TO cord-010092-uftc8inx 2712 20 increase increase VB cord-010092-uftc8inx 2712 21 plasma plasma NN cord-010092-uftc8inx 2712 22 collections collection NNS cord-010092-uftc8inx 2712 23 . . . cord-010092-uftc8inx 2713 1 First first JJ cord-010092-uftc8inx 2713 2 - - HYPH cord-010092-uftc8inx 2713 3 time time NN cord-010092-uftc8inx 2713 4 donor donor NN cord-010092-uftc8inx 2713 5 retention retention NN cord-010092-uftc8inx 2713 6 , , , cord-010092-uftc8inx 2713 7 including include VBG cord-010092-uftc8inx 2713 8 the the DT cord-010092-uftc8inx 2713 9 rate rate NN cord-010092-uftc8inx 2713 10 at at IN cord-010092-uftc8inx 2713 11 which which WDT cord-010092-uftc8inx 2713 12 first first JJ cord-010092-uftc8inx 2713 13 - - HYPH cord-010092-uftc8inx 2713 14 time time NN cord-010092-uftc8inx 2713 15 donors donor NNS cord-010092-uftc8inx 2713 16 return return VBP cord-010092-uftc8inx 2713 17 , , , cord-010092-uftc8inx 2713 18 is be VBZ cord-010092-uftc8inx 2713 19 a a DT cord-010092-uftc8inx 2713 20 pressing press VBG cord-010092-uftc8inx 2713 21 issue issue NN cord-010092-uftc8inx 2713 22 . . . cord-010092-uftc8inx 2714 1 A a DT cord-010092-uftc8inx 2714 2 quick quick JJ cord-010092-uftc8inx 2714 3 return return NN cord-010092-uftc8inx 2714 4 is be VBZ cord-010092-uftc8inx 2714 5 optimal optimal JJ cord-010092-uftc8inx 2714 6 as as IN cord-010092-uftc8inx 2714 7 this this DT cord-010092-uftc8inx 2714 8 increases increase VBZ cord-010092-uftc8inx 2714 9 the the DT cord-010092-uftc8inx 2714 10 overall overall JJ cord-010092-uftc8inx 2714 11 plasma plasma NN cord-010092-uftc8inx 2714 12 yield yield NN cord-010092-uftc8inx 2714 13 and and CC cord-010092-uftc8inx 2714 14 is be VBZ cord-010092-uftc8inx 2714 15 associated associate VBN cord-010092-uftc8inx 2714 16 with with IN cord-010092-uftc8inx 2714 17 long long JJ cord-010092-uftc8inx 2714 18 - - HYPH cord-010092-uftc8inx 2714 19 term term NN cord-010092-uftc8inx 2714 20 retention retention NN cord-010092-uftc8inx 2714 21 . . . cord-010092-uftc8inx 2715 1 However however RB cord-010092-uftc8inx 2715 2 , , , cord-010092-uftc8inx 2715 3 we -PRON- PRP cord-010092-uftc8inx 2715 4 lack lack VBP cord-010092-uftc8inx 2715 5 evidence evidence NN cord-010092-uftc8inx 2715 6 of of IN cord-010092-uftc8inx 2715 7 effective effective JJ cord-010092-uftc8inx 2715 8 interventions intervention NNS cord-010092-uftc8inx 2715 9 to to TO cord-010092-uftc8inx 2715 10 encourage encourage VB cord-010092-uftc8inx 2715 11 first first JJ cord-010092-uftc8inx 2715 12 - - HYPH cord-010092-uftc8inx 2715 13 time time NN cord-010092-uftc8inx 2715 14 donors donor NNS cord-010092-uftc8inx 2715 15 , , , cord-010092-uftc8inx 2715 16 particularly particularly RB cord-010092-uftc8inx 2715 17 those those DT cord-010092-uftc8inx 2715 18 donating donate VBG cord-010092-uftc8inx 2715 19 plasma plasma NN cord-010092-uftc8inx 2715 20 , , , cord-010092-uftc8inx 2715 21 to to TO cord-010092-uftc8inx 2715 22 return return VB cord-010092-uftc8inx 2715 23 and and CC cord-010092-uftc8inx 2715 24 to to TO cord-010092-uftc8inx 2715 25 establish establish VB cord-010092-uftc8inx 2715 26 a a DT cord-010092-uftc8inx 2715 27 higher high JJR cord-010092-uftc8inx 2715 28 frequency frequency NN cord-010092-uftc8inx 2715 29 donation donation NN cord-010092-uftc8inx 2715 30 routine routine NN cord-010092-uftc8inx 2715 31 . . . cord-010092-uftc8inx 2716 1 Working work VBG cord-010092-uftc8inx 2716 2 from from IN cord-010092-uftc8inx 2716 3 Schultz Schultz NNP cord-010092-uftc8inx 2716 4 's 's POS cord-010092-uftc8inx 2716 5 ( ( -LRB- cord-010092-uftc8inx 2716 6 2014 2014 CD cord-010092-uftc8inx 2716 7 ) ) -RRB- cord-010092-uftc8inx 2716 8 framework framework NN cord-010092-uftc8inx 2716 9 , , , cord-010092-uftc8inx 2716 10 this this DT cord-010092-uftc8inx 2716 11 intervention intervention NN cord-010092-uftc8inx 2716 12 study study NN cord-010092-uftc8inx 2716 13 was be VBD cord-010092-uftc8inx 2716 14 based base VBN cord-010092-uftc8inx 2716 15 upon upon IN cord-010092-uftc8inx 2716 16 insights insight NNS cord-010092-uftc8inx 2716 17 from from IN cord-010092-uftc8inx 2716 18 interviews interview NNS cord-010092-uftc8inx 2716 19 with with IN cord-010092-uftc8inx 2716 20 first first JJ cord-010092-uftc8inx 2716 21 - - HYPH cord-010092-uftc8inx 2716 22 time time NN cord-010092-uftc8inx 2716 23 plasmapheresis plasmapheresis NN cord-010092-uftc8inx 2716 24 donors donor NNS cord-010092-uftc8inx 2716 25 . . . cord-010092-uftc8inx 2717 1 Participants participant NNS cord-010092-uftc8inx 2717 2 identified identify VBD cord-010092-uftc8inx 2717 3 barriers barrier NNS cord-010092-uftc8inx 2717 4 such such JJ cord-010092-uftc8inx 2717 5 as as IN cord-010092-uftc8inx 2717 6 time time NN cord-010092-uftc8inx 2717 7 and and CC cord-010092-uftc8inx 2717 8 lack lack NN cord-010092-uftc8inx 2717 9 of of IN cord-010092-uftc8inx 2717 10 knowledge knowledge NN cord-010092-uftc8inx 2717 11 about about IN cord-010092-uftc8inx 2717 12 plasmapheresis plasmapheresis NN cord-010092-uftc8inx 2717 13 . . . cord-010092-uftc8inx 2718 1 Facilitators facilitator NNS cord-010092-uftc8inx 2718 2 included include VBD cord-010092-uftc8inx 2718 3 being be VBG cord-010092-uftc8inx 2718 4 able able JJ cord-010092-uftc8inx 2718 5 to to TO cord-010092-uftc8inx 2718 6 help help VB cord-010092-uftc8inx 2718 7 more more JJR cord-010092-uftc8inx 2718 8 people people NNS cord-010092-uftc8inx 2718 9 and and CC cord-010092-uftc8inx 2718 10 to to TO cord-010092-uftc8inx 2718 11 donate donate VB cord-010092-uftc8inx 2718 12 more more RBR cord-010092-uftc8inx 2718 13 frequently frequently RB cord-010092-uftc8inx 2718 14 than than IN cord-010092-uftc8inx 2718 15 allowed allow VBN cord-010092-uftc8inx 2718 16 with with IN cord-010092-uftc8inx 2718 17 whole whole JJ cord-010092-uftc8inx 2718 18 blood blood NN cord-010092-uftc8inx 2718 19 . . . cord-010092-uftc8inx 2719 1 Participants participant NNS cord-010092-uftc8inx 2719 2 generally generally RB cord-010092-uftc8inx 2719 3 favoured favour VBD cord-010092-uftc8inx 2719 4 donating donating NN cord-010092-uftc8inx 2719 5 at at IN cord-010092-uftc8inx 2719 6 a a DT cord-010092-uftc8inx 2719 7 frequency frequency NN cord-010092-uftc8inx 2719 8 of of IN cord-010092-uftc8inx 2719 9 every every DT cord-010092-uftc8inx 2719 10 4 4 CD cord-010092-uftc8inx 2719 11 weeks week NNS cord-010092-uftc8inx 2719 12 . . . cord-010092-uftc8inx 2720 1 Aims aim VBZ cord-010092-uftc8inx 2720 2 : : : cord-010092-uftc8inx 2721 1 The the DT cord-010092-uftc8inx 2721 2 aim aim NN cord-010092-uftc8inx 2721 3 of of IN cord-010092-uftc8inx 2721 4 this this DT cord-010092-uftc8inx 2721 5 study study NN cord-010092-uftc8inx 2721 6 was be VBD cord-010092-uftc8inx 2721 7 to to TO cord-010092-uftc8inx 2721 8 test test VB cord-010092-uftc8inx 2721 9 the the DT cord-010092-uftc8inx 2721 10 effectiveness effectiveness NN cord-010092-uftc8inx 2721 11 of of IN cord-010092-uftc8inx 2721 12 three three CD cord-010092-uftc8inx 2721 13 intervention intervention NN cord-010092-uftc8inx 2721 14 conditions condition NNS cord-010092-uftc8inx 2721 15 compared compare VBN cord-010092-uftc8inx 2721 16 with with IN cord-010092-uftc8inx 2721 17 the the DT cord-010092-uftc8inx 2721 18 business business NN cord-010092-uftc8inx 2721 19 - - HYPH cord-010092-uftc8inx 2721 20 as as IN cord-010092-uftc8inx 2721 21 - - HYPH cord-010092-uftc8inx 2721 22 usual usual JJ cord-010092-uftc8inx 2721 23 ( ( -LRB- cord-010092-uftc8inx 2721 24 BAU bau NN cord-010092-uftc8inx 2721 25 ) ) -RRB- cord-010092-uftc8inx 2721 26 procedure procedure NN cord-010092-uftc8inx 2721 27 on on IN cord-010092-uftc8inx 2721 28 the the DT cord-010092-uftc8inx 2721 29 proportion proportion NN cord-010092-uftc8inx 2721 30 of of IN cord-010092-uftc8inx 2721 31 donors donor NNS cord-010092-uftc8inx 2721 32 returning return VBG cord-010092-uftc8inx 2721 33 to to TO cord-010092-uftc8inx 2721 34 donate donate VB cord-010092-uftc8inx 2721 35 plasma plasma NN cord-010092-uftc8inx 2721 36 and and CC cord-010092-uftc8inx 2721 37 the the DT cord-010092-uftc8inx 2721 38 number number NN cord-010092-uftc8inx 2721 39 of of IN cord-010092-uftc8inx 2721 40 plasma plasma NN cord-010092-uftc8inx 2721 41 donations donation NNS cord-010092-uftc8inx 2721 42 . . . cord-010092-uftc8inx 2722 1 We -PRON- PRP cord-010092-uftc8inx 2722 2 report report VBP cord-010092-uftc8inx 2722 3 on on IN cord-010092-uftc8inx 2722 4 the the DT cord-010092-uftc8inx 2722 5 data datum NNS cord-010092-uftc8inx 2722 6 from from IN cord-010092-uftc8inx 2722 7 2 2 CD cord-010092-uftc8inx 2722 8 months month NNS cord-010092-uftc8inx 2722 9 post post NN cord-010092-uftc8inx 2722 10 - - NN cord-010092-uftc8inx 2722 11 donation donation NN cord-010092-uftc8inx 2722 12 . . . cord-010092-uftc8inx 2723 1 Methods method NNS cord-010092-uftc8inx 2723 2 : : : cord-010092-uftc8inx 2723 3 Donors donor NNS cord-010092-uftc8inx 2723 4 were be VBD cord-010092-uftc8inx 2723 5 randomly randomly RB cord-010092-uftc8inx 2723 6 assigned assign VBN cord-010092-uftc8inx 2723 7 to to IN cord-010092-uftc8inx 2723 8 one one CD cord-010092-uftc8inx 2723 9 of of IN cord-010092-uftc8inx 2723 10 four four CD cord-010092-uftc8inx 2723 11 study study NN cord-010092-uftc8inx 2723 12 conditions condition NNS cord-010092-uftc8inx 2723 13 . . . cord-010092-uftc8inx 2724 1 In in IN cord-010092-uftc8inx 2724 2 Conditions condition NNS cord-010092-uftc8inx 2724 3 1 1 CD cord-010092-uftc8inx 2724 4 and and CC cord-010092-uftc8inx 2724 5 2 2 CD cord-010092-uftc8inx 2724 6 , , , cord-010092-uftc8inx 2724 7 donors donor NNS cord-010092-uftc8inx 2724 8 received receive VBD cord-010092-uftc8inx 2724 9 an an DT cord-010092-uftc8inx 2724 10 email email NN cord-010092-uftc8inx 2724 11 one one CD cord-010092-uftc8inx 2724 12 day day NN cord-010092-uftc8inx 2724 13 after after IN cord-010092-uftc8inx 2724 14 their -PRON- PRP$ cord-010092-uftc8inx 2724 15 initial initial JJ cord-010092-uftc8inx 2724 16 donation donation NN cord-010092-uftc8inx 2724 17 . . . cord-010092-uftc8inx 2725 1 In in IN cord-010092-uftc8inx 2725 2 the the DT cord-010092-uftc8inx 2725 3 first first JJ cord-010092-uftc8inx 2725 4 condition condition NN cord-010092-uftc8inx 2725 5 , , , cord-010092-uftc8inx 2725 6 donors donor NNS cord-010092-uftc8inx 2725 7 received receive VBD cord-010092-uftc8inx 2725 8 the the DT cord-010092-uftc8inx 2725 9 BAU BAU NNP cord-010092-uftc8inx 2725 10 ' ' POS cord-010092-uftc8inx 2725 11 thankyou thankyou NN cord-010092-uftc8inx 2725 12 ' ' '' cord-010092-uftc8inx 2725 13 email email NN cord-010092-uftc8inx 2725 14 . . . cord-010092-uftc8inx 2726 1 Donors donor NNS cord-010092-uftc8inx 2726 2 in in IN cord-010092-uftc8inx 2726 3 the the DT cord-010092-uftc8inx 2726 4 second second JJ cord-010092-uftc8inx 2726 5 condition condition NN cord-010092-uftc8inx 2726 6 received receive VBD cord-010092-uftc8inx 2726 7 an an DT cord-010092-uftc8inx 2726 8 alternative alternative JJ cord-010092-uftc8inx 2726 9 email email NN cord-010092-uftc8inx 2726 10 with with IN cord-010092-uftc8inx 2726 11 content content NN cord-010092-uftc8inx 2726 12 derived derive VBN cord-010092-uftc8inx 2726 13 from from IN cord-010092-uftc8inx 2726 14 the the DT cord-010092-uftc8inx 2726 15 interview interview NN cord-010092-uftc8inx 2726 16 study study NN cord-010092-uftc8inx 2726 17 . . . cord-010092-uftc8inx 2727 1 Donors donor NNS cord-010092-uftc8inx 2727 2 in in IN cord-010092-uftc8inx 2727 3 the the DT cord-010092-uftc8inx 2727 4 remaining remain VBG cord-010092-uftc8inx 2727 5 conditions condition NNS cord-010092-uftc8inx 2727 6 received receive VBN cord-010092-uftc8inx 2727 7 either either CC cord-010092-uftc8inx 2727 8 the the DT cord-010092-uftc8inx 2727 9 BAU BAU NNP cord-010092-uftc8inx 2727 10 email email NN cord-010092-uftc8inx 2727 11 ( ( -LRB- cord-010092-uftc8inx 2727 12 Condition Condition NNP cord-010092-uftc8inx 2727 13 3 3 CD cord-010092-uftc8inx 2727 14 ) ) -RRB- cord-010092-uftc8inx 2727 15 or or CC cord-010092-uftc8inx 2727 16 the the DT cord-010092-uftc8inx 2727 17 revised revise VBN cord-010092-uftc8inx 2727 18 email email NN cord-010092-uftc8inx 2727 19 ( ( -LRB- cord-010092-uftc8inx 2727 20 Condition Condition NNP cord-010092-uftc8inx 2727 21 4 4 CD cord-010092-uftc8inx 2727 22 ) ) -RRB- cord-010092-uftc8inx 2727 23 coupled couple VBN cord-010092-uftc8inx 2727 24 with with IN cord-010092-uftc8inx 2727 25 a a DT cord-010092-uftc8inx 2727 26 telephone telephone NN cord-010092-uftc8inx 2727 27 call call NN cord-010092-uftc8inx 2727 28 . . . cord-010092-uftc8inx 2728 1 The the DT cord-010092-uftc8inx 2728 2 phone phone NN cord-010092-uftc8inx 2728 3 call call NN cord-010092-uftc8inx 2728 4 was be VBD cord-010092-uftc8inx 2728 5 scripted script VBN cord-010092-uftc8inx 2728 6 to to TO cord-010092-uftc8inx 2728 7 provide provide VB cord-010092-uftc8inx 2728 8 additional additional JJ cord-010092-uftc8inx 2728 9 information information NN cord-010092-uftc8inx 2728 10 about about IN cord-010092-uftc8inx 2728 11 plasma plasma NN cord-010092-uftc8inx 2728 12 , , , cord-010092-uftc8inx 2728 13 including include VBG cord-010092-uftc8inx 2728 14 how how WRB cord-010092-uftc8inx 2728 15 often often RB cord-010092-uftc8inx 2728 16 plasma plasma NN cord-010092-uftc8inx 2728 17 can can MD cord-010092-uftc8inx 2728 18 be be VB cord-010092-uftc8inx 2728 19 donated donate VBN cord-010092-uftc8inx 2728 20 , , , cord-010092-uftc8inx 2728 21 a a DT cord-010092-uftc8inx 2728 22 suggestion suggestion NN cord-010092-uftc8inx 2728 23 to to TO cord-010092-uftc8inx 2728 24 donate donate VB cord-010092-uftc8inx 2728 25 every every DT cord-010092-uftc8inx 2728 26 4 4 CD cord-010092-uftc8inx 2728 27 weeks week NNS cord-010092-uftc8inx 2728 28 , , , cord-010092-uftc8inx 2728 29 and and CC cord-010092-uftc8inx 2728 30 a a DT cord-010092-uftc8inx 2728 31 prompt prompt NN cord-010092-uftc8inx 2728 32 to to IN cord-010092-uftc8inx 2728 33 forward forward JJ cord-010092-uftc8inx 2728 34 - - HYPH cord-010092-uftc8inx 2728 35 book book NN cord-010092-uftc8inx 2728 36 appointments appointment NNS cord-010092-uftc8inx 2728 37 . . . cord-010092-uftc8inx 2729 1 Results result NNS cord-010092-uftc8inx 2729 2 : : : cord-010092-uftc8inx 2730 1 The the DT cord-010092-uftc8inx 2730 2 final final JJ cord-010092-uftc8inx 2730 3 sample sample NN cord-010092-uftc8inx 2730 4 ( ( -LRB- cord-010092-uftc8inx 2730 5 N n NN cord-010092-uftc8inx 2730 6 = = SYM cord-010092-uftc8inx 2730 7 6788 6788 CD cord-010092-uftc8inx 2730 8 ) ) -RRB- cord-010092-uftc8inx 2730 9 comprised comprise VBD cord-010092-uftc8inx 2730 10 3859 3859 CD cord-010092-uftc8inx 2730 11 women woman NNS cord-010092-uftc8inx 2730 12 ( ( -LRB- cord-010092-uftc8inx 2730 13 57 57 CD cord-010092-uftc8inx 2730 14 % % NN cord-010092-uftc8inx 2730 15 ) ) -RRB- cord-010092-uftc8inx 2730 16 and and CC cord-010092-uftc8inx 2730 17 2929 2929 CD cord-010092-uftc8inx 2730 18 men man NNS cord-010092-uftc8inx 2730 19 ( ( -LRB- cord-010092-uftc8inx 2730 20 43 43 CD cord-010092-uftc8inx 2730 21 % % NN cord-010092-uftc8inx 2730 22 ) ) -RRB- cord-010092-uftc8inx 2730 23 aged age VBN cord-010092-uftc8inx 2730 24 18 18 CD cord-010092-uftc8inx 2730 25 - - SYM cord-010092-uftc8inx 2730 26 70 70 CD cord-010092-uftc8inx 2730 27 ( ( -LRB- cord-010092-uftc8inx 2730 28 mean mean VB cord-010092-uftc8inx 2730 29 = = SYM cord-010092-uftc8inx 2730 30 32 32 CD cord-010092-uftc8inx 2730 31 ) ) -RRB- cord-010092-uftc8inx 2730 32 . . . cord-010092-uftc8inx 2731 1 After after IN cord-010092-uftc8inx 2731 2 two two CD cord-010092-uftc8inx 2731 3 months month NNS cord-010092-uftc8inx 2731 4 37.2 37.2 CD cord-010092-uftc8inx 2731 5 % % NN cord-010092-uftc8inx 2731 6 of of IN cord-010092-uftc8inx 2731 7 donors donor NNS cord-010092-uftc8inx 2731 8 returned return VBN cord-010092-uftc8inx 2731 9 to to TO cord-010092-uftc8inx 2731 10 donate donate VB cord-010092-uftc8inx 2731 11 plasma plasma NN cord-010092-uftc8inx 2731 12 at at IN cord-010092-uftc8inx 2731 13 least least JJS cord-010092-uftc8inx 2731 14 once once RB cord-010092-uftc8inx 2731 15 . . . cord-010092-uftc8inx 2732 1 After after IN cord-010092-uftc8inx 2732 2 controlling control VBG cord-010092-uftc8inx 2732 3 for for IN cord-010092-uftc8inx 2732 4 gender gender NN cord-010092-uftc8inx 2732 5 , , , cord-010092-uftc8inx 2732 6 age age NN cord-010092-uftc8inx 2732 7 , , , cord-010092-uftc8inx 2732 8 and and CC cord-010092-uftc8inx 2732 9 blood blood NN cord-010092-uftc8inx 2732 10 group group NN cord-010092-uftc8inx 2732 11 , , , cord-010092-uftc8inx 2732 12 donors donor NNS cord-010092-uftc8inx 2732 13 in in IN cord-010092-uftc8inx 2732 14 each each DT cord-010092-uftc8inx 2732 15 of of IN cord-010092-uftc8inx 2732 16 the the DT cord-010092-uftc8inx 2732 17 intervention intervention NN cord-010092-uftc8inx 2732 18 conditions condition NNS cord-010092-uftc8inx 2732 19 were be VBD cord-010092-uftc8inx 2732 20 more more RBR cord-010092-uftc8inx 2732 21 likely likely JJ cord-010092-uftc8inx 2732 22 to to TO cord-010092-uftc8inx 2732 23 return return VB cord-010092-uftc8inx 2732 24 to to TO cord-010092-uftc8inx 2732 25 donate donate VB cord-010092-uftc8inx 2732 26 plasma plasma NN cord-010092-uftc8inx 2732 27 than than IN cord-010092-uftc8inx 2732 28 were be VBD cord-010092-uftc8inx 2732 29 donors donor NNS cord-010092-uftc8inx 2732 30 in in IN cord-010092-uftc8inx 2732 31 the the DT cord-010092-uftc8inx 2732 32 BAU BAU NNP cord-010092-uftc8inx 2732 33 condition condition NN cord-010092-uftc8inx 2732 34 . . . cord-010092-uftc8inx 2733 1 The the DT cord-010092-uftc8inx 2733 2 greatest great JJS cord-010092-uftc8inx 2733 3 effect effect NN cord-010092-uftc8inx 2733 4 was be VBD cord-010092-uftc8inx 2733 5 found find VBN cord-010092-uftc8inx 2733 6 between between IN cord-010092-uftc8inx 2733 7 donors donor NNS cord-010092-uftc8inx 2733 8 randomized randomize VBN cord-010092-uftc8inx 2733 9 to to IN cord-010092-uftc8inx 2733 10 Condition Condition NNP cord-010092-uftc8inx 2733 11 4 4 CD cord-010092-uftc8inx 2733 12 ( ( -LRB- cord-010092-uftc8inx 2733 13 revised revise VBN cord-010092-uftc8inx 2733 14 email email NN cord-010092-uftc8inx 2733 15 + + CC cord-010092-uftc8inx 2733 16 phone phone NN cord-010092-uftc8inx 2733 17 call call NN cord-010092-uftc8inx 2733 18 ) ) -RRB- cord-010092-uftc8inx 2733 19 , , , cord-010092-uftc8inx 2733 20 OR or CC cord-010092-uftc8inx 2733 21 = = SYM cord-010092-uftc8inx 2733 22 1.305 1.305 CD cord-010092-uftc8inx 2733 23 , , , cord-010092-uftc8inx 2733 24 CI CI NNP cord-010092-uftc8inx 2733 25 = = SYM cord-010092-uftc8inx 2733 26 1.128 1.128 CD cord-010092-uftc8inx 2733 27 - - HYPH cord-010092-uftc8inx 2733 28 1.510 1.510 CD cord-010092-uftc8inx 2733 29 , , , cord-010092-uftc8inx 2733 30 and and CC cord-010092-uftc8inx 2733 31 BAU BAU NNP cord-010092-uftc8inx 2733 32 . . . cord-010092-uftc8inx 2734 1 Donors donor NNS cord-010092-uftc8inx 2734 2 assigned assign VBN cord-010092-uftc8inx 2734 3 to to IN cord-010092-uftc8inx 2734 4 the the DT cord-010092-uftc8inx 2734 5 two two CD cord-010092-uftc8inx 2734 6 telephone telephone NN cord-010092-uftc8inx 2734 7 conditions condition NNS cord-010092-uftc8inx 2734 8 ( ( -LRB- cord-010092-uftc8inx 2734 9 Condition Condition NNP cord-010092-uftc8inx 2734 10 3 3 CD cord-010092-uftc8inx 2734 11 and and CC cord-010092-uftc8inx 2734 12 4 4 CD cord-010092-uftc8inx 2734 13 ) ) -RRB- cord-010092-uftc8inx 2734 14 donated donate VBN cord-010092-uftc8inx 2734 15 plasma plasma NN cord-010092-uftc8inx 2734 16 at at IN cord-010092-uftc8inx 2734 17 a a DT cord-010092-uftc8inx 2734 18 higher high JJR cord-010092-uftc8inx 2734 19 frequency frequency NN cord-010092-uftc8inx 2734 20 than than IN cord-010092-uftc8inx 2734 21 BAU BAU NNP cord-010092-uftc8inx 2734 22 . . . cord-010092-uftc8inx 2735 1 Summary Summary NNP cord-010092-uftc8inx 2735 2 / / SYM cord-010092-uftc8inx 2735 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 2735 4 : : : cord-010092-uftc8inx 2736 1 This this DT cord-010092-uftc8inx 2736 2 study study NN cord-010092-uftc8inx 2736 3 tested test VBD cord-010092-uftc8inx 2736 4 the the DT cord-010092-uftc8inx 2736 5 effectiveness effectiveness NN cord-010092-uftc8inx 2736 6 of of IN cord-010092-uftc8inx 2736 7 interventions intervention NNS cord-010092-uftc8inx 2736 8 designed design VBN cord-010092-uftc8inx 2736 9 to to TO cord-010092-uftc8inx 2736 10 encourage encourage VB cord-010092-uftc8inx 2736 11 first first JJ cord-010092-uftc8inx 2736 12 - - HYPH cord-010092-uftc8inx 2736 13 time time NN cord-010092-uftc8inx 2736 14 plasma plasma NN cord-010092-uftc8inx 2736 15 donors donor NNS cord-010092-uftc8inx 2736 16 to to TO cord-010092-uftc8inx 2736 17 return return VB cord-010092-uftc8inx 2736 18 to to TO cord-010092-uftc8inx 2736 19 donate donate VB cord-010092-uftc8inx 2736 20 plasma plasma NN cord-010092-uftc8inx 2736 21 and and CC cord-010092-uftc8inx 2736 22 to to TO cord-010092-uftc8inx 2736 23 establish establish VB cord-010092-uftc8inx 2736 24 a a DT cord-010092-uftc8inx 2736 25 routine routine NN cord-010092-uftc8inx 2736 26 of of IN cord-010092-uftc8inx 2736 27 donation donation NN cord-010092-uftc8inx 2736 28 . . . cord-010092-uftc8inx 2737 1 Early early JJ cord-010092-uftc8inx 2737 2 indicators indicator NNS cord-010092-uftc8inx 2737 3 suggest suggest VBP cord-010092-uftc8inx 2737 4 that that IN cord-010092-uftc8inx 2737 5 the the DT cord-010092-uftc8inx 2737 6 evidence evidence NN cord-010092-uftc8inx 2737 7 - - HYPH cord-010092-uftc8inx 2737 8 based base VBN cord-010092-uftc8inx 2737 9 email email NN cord-010092-uftc8inx 2737 10 and and CC cord-010092-uftc8inx 2737 11 phone phone NN cord-010092-uftc8inx 2737 12 call call NN cord-010092-uftc8inx 2737 13 elements element NNS cord-010092-uftc8inx 2737 14 are be VBP cord-010092-uftc8inx 2737 15 more more RBR cord-010092-uftc8inx 2737 16 effective effective JJ cord-010092-uftc8inx 2737 17 than than IN cord-010092-uftc8inx 2737 18 BAU BAU NNP cord-010092-uftc8inx 2737 19 in in IN cord-010092-uftc8inx 2737 20 bringing bring VBG cord-010092-uftc8inx 2737 21 donors donor NNS cord-010092-uftc8inx 2737 22 back back RB cord-010092-uftc8inx 2737 23 to to TO cord-010092-uftc8inx 2737 24 donate donate VB cord-010092-uftc8inx 2737 25 plasma plasma NN cord-010092-uftc8inx 2737 26 , , , cord-010092-uftc8inx 2737 27 and and CC cord-010092-uftc8inx 2737 28 the the DT cord-010092-uftc8inx 2737 29 revised revise VBN cord-010092-uftc8inx 2737 30 email email NN cord-010092-uftc8inx 2737 31 combined combine VBN cord-010092-uftc8inx 2737 32 with with IN cord-010092-uftc8inx 2737 33 a a DT cord-010092-uftc8inx 2737 34 phone phone NN cord-010092-uftc8inx 2737 35 call call NN cord-010092-uftc8inx 2737 36 had have VBD cord-010092-uftc8inx 2737 37 the the DT cord-010092-uftc8inx 2737 38 greatest great JJS cord-010092-uftc8inx 2737 39 positive positive JJ cord-010092-uftc8inx 2737 40 effect effect NN cord-010092-uftc8inx 2737 41 on on IN cord-010092-uftc8inx 2737 42 short short JJ cord-010092-uftc8inx 2737 43 - - HYPH cord-010092-uftc8inx 2737 44 term term NN cord-010092-uftc8inx 2737 45 plasma plasma NN cord-010092-uftc8inx 2737 46 yield yield NN cord-010092-uftc8inx 2737 47 . . . cord-010092-uftc8inx 2738 1 Background background NN cord-010092-uftc8inx 2738 2 : : : cord-010092-uftc8inx 2739 1 Healthy healthy JJ cord-010092-uftc8inx 2739 2 individuals individual NNS cord-010092-uftc8inx 2739 3 with with IN cord-010092-uftc8inx 2739 4 hereditary hereditary JJ cord-010092-uftc8inx 2739 5 hemochromatosis hemochromatosis NN cord-010092-uftc8inx 2739 6 ( ( -LRB- cord-010092-uftc8inx 2740 1 HH HH NNP cord-010092-uftc8inx 2740 2 defined define VBN cord-010092-uftc8inx 2740 3 as as IN cord-010092-uftc8inx 2740 4 hyperferritinemia hyperferritinemia NNP cord-010092-uftc8inx 2740 5 and and CC cord-010092-uftc8inx 2740 6 homozygous homozygous NNP cord-010092-uftc8inx 2740 7 p. p. NN cord-010092-uftc8inx 2741 1 C282Y c282y JJ cord-010092-uftc8inx 2741 2 mutation mutation NN cord-010092-uftc8inx 2741 3 ) ) -RRB- cord-010092-uftc8inx 2741 4 , , , cord-010092-uftc8inx 2741 5 but but CC cord-010092-uftc8inx 2741 6 also also RB cord-010092-uftc8inx 2741 7 carriers carrier NNS cord-010092-uftc8inx 2741 8 of of IN cord-010092-uftc8inx 2741 9 other other JJ cord-010092-uftc8inx 2741 10 HFE HFE NNP cord-010092-uftc8inx 2741 11 mutations mutation NNS cord-010092-uftc8inx 2741 12 ( ( -LRB- cord-010092-uftc8inx 2741 13 p p NN cord-010092-uftc8inx 2741 14 . . . cord-010092-uftc8inx 2741 15 C282Y C282Y NNP cord-010092-uftc8inx 2741 16 / / SYM cord-010092-uftc8inx 2741 17 p p NN cord-010092-uftc8inx 2741 18 . . . cord-010092-uftc8inx 2742 1 H63D H63D NNP cord-010092-uftc8inx 2742 2 or or CC cord-010092-uftc8inx 2742 3 homozygous homozygous JJ cord-010092-uftc8inx 2742 4 H63D h63d NN cord-010092-uftc8inx 2742 5 ) ) -RRB- cord-010092-uftc8inx 2742 6 with with IN cord-010092-uftc8inx 2742 7 elevated elevated JJ cord-010092-uftc8inx 2742 8 serum serum NN cord-010092-uftc8inx 2742 9 ferritin ferritin NN cord-010092-uftc8inx 2742 10 ( ( -LRB- cord-010092-uftc8inx 2742 11 SF SF NNP cord-010092-uftc8inx 2742 12 ) ) -RRB- cord-010092-uftc8inx 2742 13 are be VBP cord-010092-uftc8inx 2742 14 accepted accept VBN cord-010092-uftc8inx 2742 15 as as IN cord-010092-uftc8inx 2742 16 blood blood NN cord-010092-uftc8inx 2742 17 donors donor NNS cord-010092-uftc8inx 2742 18 , , , cord-010092-uftc8inx 2742 19 if if IN cord-010092-uftc8inx 2742 20 allowed allow VBN cord-010092-uftc8inx 2742 21 by by IN cord-010092-uftc8inx 2742 22 local local JJ cord-010092-uftc8inx 2742 23 regulations regulation NNS cord-010092-uftc8inx 2742 24 and and CC cord-010092-uftc8inx 2742 25 if if IN cord-010092-uftc8inx 2742 26 eligibility eligibility NN cord-010092-uftc8inx 2742 27 is be VBZ cord-010092-uftc8inx 2742 28 fulfilled fulfil VBN cord-010092-uftc8inx 2742 29 . . . cord-010092-uftc8inx 2743 1 Generally generally RB cord-010092-uftc8inx 2743 2 , , , cord-010092-uftc8inx 2743 3 blood blood NN cord-010092-uftc8inx 2743 4 components component NNS cord-010092-uftc8inx 2743 5 are be VBP cord-010092-uftc8inx 2743 6 released release VBN cord-010092-uftc8inx 2743 7 for for IN cord-010092-uftc8inx 2743 8 transfusion transfusion NN cord-010092-uftc8inx 2743 9 at at IN cord-010092-uftc8inx 2743 10 normal normal JJ cord-010092-uftc8inx 2743 11 SF SF NNP cord-010092-uftc8inx 2743 12 levels level NNS cord-010092-uftc8inx 2743 13 ( ( -LRB- cord-010092-uftc8inx 2743 14 < < XX cord-010092-uftc8inx 2743 15 200 200 CD cord-010092-uftc8inx 2743 16 ng ng NN cord-010092-uftc8inx 2743 17 / / SYM cord-010092-uftc8inx 2743 18 mL ml NN cord-010092-uftc8inx 2743 19 in in IN cord-010092-uftc8inx 2743 20 females female NNS cord-010092-uftc8inx 2743 21 , , , cord-010092-uftc8inx 2743 22 < < XX cord-010092-uftc8inx 2743 23 300 300 CD cord-010092-uftc8inx 2743 24 ng ng NN cord-010092-uftc8inx 2743 25 / / SYM cord-010092-uftc8inx 2743 26 mL ml NN cord-010092-uftc8inx 2743 27 in in IN cord-010092-uftc8inx 2743 28 males male NNS cord-010092-uftc8inx 2743 29 ) ) -RRB- cord-010092-uftc8inx 2743 30 . . . cord-010092-uftc8inx 2744 1 Aims aim VBZ cord-010092-uftc8inx 2744 2 : : : cord-010092-uftc8inx 2744 3 Prospective prospective JJ cord-010092-uftc8inx 2744 4 , , , cord-010092-uftc8inx 2744 5 two two CD cord-010092-uftc8inx 2744 6 - - HYPH cord-010092-uftc8inx 2744 7 center center NN cord-010092-uftc8inx 2744 8 , , , cord-010092-uftc8inx 2744 9 randomized randomized JJ cord-010092-uftc8inx 2744 10 study study NN cord-010092-uftc8inx 2744 11 comparing compare VBG cord-010092-uftc8inx 2744 12 the the DT cord-010092-uftc8inx 2744 13 efficacy efficacy NN cord-010092-uftc8inx 2744 14 and and CC cord-010092-uftc8inx 2744 15 tolerability tolerability NN cord-010092-uftc8inx 2744 16 of of IN cord-010092-uftc8inx 2744 17 double double JJ cord-010092-uftc8inx 2744 18 - - HYPH cord-010092-uftc8inx 2744 19 erythrocyte erythrocyte NN cord-010092-uftc8inx 2744 20 apheresis apheresis NN cord-010092-uftc8inx 2744 21 ( ( -LRB- cord-010092-uftc8inx 2744 22 2RBCaph 2rbcaph JJ cord-010092-uftc8inx 2744 23 ) ) -RRB- cord-010092-uftc8inx 2744 24 and and CC cord-010092-uftc8inx 2744 25 whole whole JJ cord-010092-uftc8inx 2744 26 blood blood NN cord-010092-uftc8inx 2744 27 phlebotomy phlebotomy NN cord-010092-uftc8inx 2745 1 ( ( -LRB- cord-010092-uftc8inx 2745 2 WBph WBph NNP cord-010092-uftc8inx 2745 3 ) ) -RRB- cord-010092-uftc8inx 2745 4 for for IN cord-010092-uftc8inx 2745 5 iron iron NN cord-010092-uftc8inx 2745 6 depletion depletion NN cord-010092-uftc8inx 2745 7 in in IN cord-010092-uftc8inx 2745 8 asymptomatic asymptomatic JJ cord-010092-uftc8inx 2745 9 subjects subject NNS cord-010092-uftc8inx 2745 10 with with IN cord-010092-uftc8inx 2745 11 HH HH NNP cord-010092-uftc8inx 2745 12 or or CC cord-010092-uftc8inx 2745 13 hyperferritinemia hyperferritinemia NNP cord-010092-uftc8inx 2745 14 and and CC cord-010092-uftc8inx 2745 15 other other JJ cord-010092-uftc8inx 2745 16 HFE HFE NNP cord-010092-uftc8inx 2745 17 mutations mutation NNS cord-010092-uftc8inx 2745 18 in in IN cord-010092-uftc8inx 2745 19 the the DT cord-010092-uftc8inx 2745 20 setting setting NN cord-010092-uftc8inx 2745 21 of of IN cord-010092-uftc8inx 2745 22 routine routine JJ cord-010092-uftc8inx 2745 23 blood blood NN cord-010092-uftc8inx 2745 24 donation donation NN cord-010092-uftc8inx 2745 25 . . . cord-010092-uftc8inx 2746 1 Methods method NNS cord-010092-uftc8inx 2746 2 : : : cord-010092-uftc8inx 2747 1 Eligibility eligibility NN cord-010092-uftc8inx 2747 2 criteria criterion NNS cord-010092-uftc8inx 2747 3 included include VBD cord-010092-uftc8inx 2747 4 age age NN cord-010092-uftc8inx 2747 5 ≥ ≥ CD cord-010092-uftc8inx 2747 6 18 18 CD cord-010092-uftc8inx 2747 7 - - SYM cord-010092-uftc8inx 2747 8 60 60 CD cord-010092-uftc8inx 2747 9 years year NNS cord-010092-uftc8inx 2747 10 , , , cord-010092-uftc8inx 2747 11 total total JJ cord-010092-uftc8inx 2747 12 blood blood NN cord-010092-uftc8inx 2747 13 volume volume NN cord-010092-uftc8inx 2747 14 ≥ ≥ CD cord-010092-uftc8inx 2747 15 5 5 CD cord-010092-uftc8inx 2747 16 L L NNP cord-010092-uftc8inx 2747 17 , , , cord-010092-uftc8inx 2747 18 BMI BMI NNP cord-010092-uftc8inx 2747 19 < < XX cord-010092-uftc8inx 2747 20 35 35 CD cord-010092-uftc8inx 2747 21 kg kg NNS cord-010092-uftc8inx 2747 22 / / SYM cord-010092-uftc8inx 2747 23 m m NN cord-010092-uftc8inx 2747 24 2 2 CD cord-010092-uftc8inx 2747 25 , , , cord-010092-uftc8inx 2747 26 Hb Hb NNP cord-010092-uftc8inx 2747 27 ≥ ≥ CD cord-010092-uftc8inx 2747 28 140 140 CD cord-010092-uftc8inx 2747 29 g g NN cord-010092-uftc8inx 2747 30 / / SYM cord-010092-uftc8inx 2747 31 L L NNP cord-010092-uftc8inx 2747 32 , , , cord-010092-uftc8inx 2747 33 elevated elevate VBN cord-010092-uftc8inx 2747 34 SF SF NNP cord-010092-uftc8inx 2747 35 levels level NNS cord-010092-uftc8inx 2747 36 and and CC cord-010092-uftc8inx 2747 37 no no DT cord-010092-uftc8inx 2747 38 end end NN cord-010092-uftc8inx 2747 39 organ organ NN cord-010092-uftc8inx 2747 40 damage damage NN cord-010092-uftc8inx 2747 41 due due IN cord-010092-uftc8inx 2747 42 to to IN cord-010092-uftc8inx 2747 43 iron iron NN cord-010092-uftc8inx 2747 44 overload overload NN cord-010092-uftc8inx 2747 45 . . . cord-010092-uftc8inx 2748 1 2RBCaph 2RBCaph NNP cord-010092-uftc8inx 2748 2 ( ( -LRB- cord-010092-uftc8inx 2748 3 360 360 CD cord-010092-uftc8inx 2748 4 mL mL NNP cord-010092-uftc8inx 2748 5 RBC RBC NNP cord-010092-uftc8inx 2748 6 ) ) -RRB- cord-010092-uftc8inx 2748 7 were be VBD cord-010092-uftc8inx 2748 8 scheduled schedule VBN cord-010092-uftc8inx 2748 9 every every DT cord-010092-uftc8inx 2748 10 14 14 CD cord-010092-uftc8inx 2748 11 days day NNS cord-010092-uftc8inx 2748 12 and and CC cord-010092-uftc8inx 2748 13 WBph WBph NNP cord-010092-uftc8inx 2748 14 ( ( -LRB- cord-010092-uftc8inx 2748 15 450 450 CD cord-010092-uftc8inx 2748 16 mL ml NN cord-010092-uftc8inx 2748 17 ) ) -RRB- cord-010092-uftc8inx 2748 18 every every DT cord-010092-uftc8inx 2748 19 7 7 CD cord-010092-uftc8inx 2748 20 days day NNS cord-010092-uftc8inx 2748 21 until until IN cord-010092-uftc8inx 2748 22 SF SF NNP cord-010092-uftc8inx 2748 23 was be VBD cord-010092-uftc8inx 2748 24 < < NNP cord-010092-uftc8inx 2748 25 100 100 CD cord-010092-uftc8inx 2748 26 ng ng NNP cord-010092-uftc8inx 2748 27 / / SYM cord-010092-uftc8inx 2748 28 mL. mL. NNS cord-010092-uftc8inx 2748 29 A a DT cord-010092-uftc8inx 2748 30 complete complete JJ cord-010092-uftc8inx 2748 31 blood blood NN cord-010092-uftc8inx 2748 32 count count NN cord-010092-uftc8inx 2748 33 and and CC cord-010092-uftc8inx 2748 34 SF SF NNP cord-010092-uftc8inx 2748 35 were be VBD cord-010092-uftc8inx 2748 36 measured measure VBN cord-010092-uftc8inx 2748 37 at at IN cord-010092-uftc8inx 2748 38 baseline baseline NN cord-010092-uftc8inx 2748 39 , , , cord-010092-uftc8inx 2748 40 at at IN cord-010092-uftc8inx 2748 41 every every DT cord-010092-uftc8inx 2748 42 visit visit NN cord-010092-uftc8inx 2748 43 and and CC cord-010092-uftc8inx 2748 44 at at IN cord-010092-uftc8inx 2748 45 follow follow VB cord-010092-uftc8inx 2748 46 up up RB cord-010092-uftc8inx 2748 47 8 8 CD cord-010092-uftc8inx 2748 48 weeks week NNS cord-010092-uftc8inx 2748 49 after after IN cord-010092-uftc8inx 2748 50 completion completion NN cord-010092-uftc8inx 2748 51 of of IN cord-010092-uftc8inx 2748 52 the the DT cord-010092-uftc8inx 2748 53 study study NN cord-010092-uftc8inx 2748 54 . . . cord-010092-uftc8inx 2749 1 Adverse adverse JJ cord-010092-uftc8inx 2749 2 events event NNS cord-010092-uftc8inx 2749 3 were be VBD cord-010092-uftc8inx 2749 4 systematically systematically RB cord-010092-uftc8inx 2749 5 recorded record VBN cord-010092-uftc8inx 2749 6 . . . cord-010092-uftc8inx 2750 1 The the DT cord-010092-uftc8inx 2750 2 treatment treatment NN cord-010092-uftc8inx 2750 3 effect effect NN cord-010092-uftc8inx 2750 4 was be VBD cord-010092-uftc8inx 2750 5 tested test VBN cord-010092-uftc8inx 2750 6 by by IN cord-010092-uftc8inx 2750 7 Poisson Poisson NNP cord-010092-uftc8inx 2750 8 regression regression NN cord-010092-uftc8inx 2750 9 , , , cord-010092-uftc8inx 2750 10 with with IN cord-010092-uftc8inx 2750 11 gender gender NN cord-010092-uftc8inx 2750 12 , , , cord-010092-uftc8inx 2750 13 HFE HFE NNP cord-010092-uftc8inx 2750 14 mutation mutation NN cord-010092-uftc8inx 2750 15 , , , cord-010092-uftc8inx 2750 16 BMI BMI NNP cord-010092-uftc8inx 2750 17 and and CC cord-010092-uftc8inx 2750 18 baseline baseline JJ cord-010092-uftc8inx 2750 19 SF SF NNP cord-010092-uftc8inx 2750 20 as as IN cord-010092-uftc8inx 2750 21 covariates covariate NNS cord-010092-uftc8inx 2750 22 . . . cord-010092-uftc8inx 2751 1 Results result NNS cord-010092-uftc8inx 2751 2 : : : cord-010092-uftc8inx 2751 3 30 30 CD cord-010092-uftc8inx 2751 4 subjects subject NNS cord-010092-uftc8inx 2751 5 ( ( -LRB- cord-010092-uftc8inx 2751 6 5 5 CD cord-010092-uftc8inx 2751 7 females female NNS cord-010092-uftc8inx 2751 8 ; ; : cord-010092-uftc8inx 2751 9 mean mean VB cord-010092-uftc8inx 2751 10 age age NN cord-010092-uftc8inx 2751 11 47 47 CD cord-010092-uftc8inx 2751 12 years year NNS cord-010092-uftc8inx 2751 13 ) ) -RRB- cord-010092-uftc8inx 2751 14 were be VBD cord-010092-uftc8inx 2751 15 randomized randomize VBN cord-010092-uftc8inx 2751 16 to to IN cord-010092-uftc8inx 2751 17 WBph WBph NNP cord-010092-uftc8inx 2751 18 ( ( -LRB- cord-010092-uftc8inx 2751 19 n n NN cord-010092-uftc8inx 2751 20 = = SYM cord-010092-uftc8inx 2751 21 16 16 CD cord-010092-uftc8inx 2751 22 ; ; : cord-010092-uftc8inx 2751 23 1 1 CD cord-010092-uftc8inx 2751 24 female female JJ cord-010092-uftc8inx 2751 25 ) ) -RRB- cord-010092-uftc8inx 2751 26 or or CC cord-010092-uftc8inx 2751 27 2RBCaph 2rbcaph CD cord-010092-uftc8inx 2752 1 ( ( -LRB- cord-010092-uftc8inx 2752 2 n n NN cord-010092-uftc8inx 2752 3 = = SYM cord-010092-uftc8inx 2752 4 14 14 CD cord-010092-uftc8inx 2752 5 ; ; : cord-010092-uftc8inx 2752 6 4 4 CD cord-010092-uftc8inx 2752 7 females female NNS cord-010092-uftc8inx 2752 8 ) ) -RRB- cord-010092-uftc8inx 2752 9 . . . cord-010092-uftc8inx 2753 1 HFE HFE NNP cord-010092-uftc8inx 2753 2 mutations mutation NNS cord-010092-uftc8inx 2753 3 were be VBD cord-010092-uftc8inx 2753 4 p p NN cord-010092-uftc8inx 2753 5 . . . cord-010092-uftc8inx 2753 6 C282/ C282/ NNP cord-010092-uftc8inx 2753 7 p. p. NN cord-010092-uftc8inx 2754 1 C282Y C282Y NNP cord-010092-uftc8inx 2754 2 in in IN cord-010092-uftc8inx 2754 3 17 17 CD cord-010092-uftc8inx 2754 4 subjects subject NNS cord-010092-uftc8inx 2754 5 , , , cord-010092-uftc8inx 2754 6 p. p. NN cord-010092-uftc8inx 2755 1 C282Y C282Y NNP cord-010092-uftc8inx 2755 2 / / SYM cord-010092-uftc8inx 2755 3 p p NN cord-010092-uftc8inx 2755 4 . . . cord-010092-uftc8inx 2756 1 H63D H63D NNP cord-010092-uftc8inx 2756 2 in in IN cord-010092-uftc8inx 2756 3 9 9 CD cord-010092-uftc8inx 2756 4 , , , cord-010092-uftc8inx 2756 5 and and CC cord-010092-uftc8inx 2756 6 p. p. NN cord-010092-uftc8inx 2757 1 H63D H63D NNP cord-010092-uftc8inx 2757 2 / / SYM cord-010092-uftc8inx 2757 3 p p NN cord-010092-uftc8inx 2757 4 . . . cord-010092-uftc8inx 2758 1 H63D H63D NNP cord-010092-uftc8inx 2758 2 in in IN cord-010092-uftc8inx 2758 3 4 4 CD cord-010092-uftc8inx 2758 4 . . . cord-010092-uftc8inx 2759 1 At at IN cord-010092-uftc8inx 2759 2 baseline baseline NN cord-010092-uftc8inx 2759 3 , , , cord-010092-uftc8inx 2759 4 mean mean JJ cord-010092-uftc8inx 2759 5 Hb Hb NNP cord-010092-uftc8inx 2759 6 was be VBD cord-010092-uftc8inx 2759 7 149 149 CD cord-010092-uftc8inx 2759 8 g g NN cord-010092-uftc8inx 2759 9 / / SYM cord-010092-uftc8inx 2759 10 L L NNP cord-010092-uftc8inx 2759 11 ( ( -LRB- cord-010092-uftc8inx 2759 12 SD SD NNP cord-010092-uftc8inx 2759 13 7.8 7.8 CD cord-010092-uftc8inx 2759 14 ) ) -RRB- cord-010092-uftc8inx 2759 15 and and CC cord-010092-uftc8inx 2759 16 median median JJ cord-010092-uftc8inx 2759 17 SF SF NNP cord-010092-uftc8inx 2759 18 was be VBD cord-010092-uftc8inx 2759 19 504 504 CD cord-010092-uftc8inx 2759 20 ng ng NN cord-010092-uftc8inx 2759 21 / / SYM cord-010092-uftc8inx 2759 22 mL ml NN cord-010092-uftc8inx 2760 1 ( ( -LRB- cord-010092-uftc8inx 2760 2 IQR IQR NNP cord-010092-uftc8inx 2760 3 406 406 CD cord-010092-uftc8inx 2760 4 - - SYM cord-010092-uftc8inx 2760 5 620 620 CD cord-010092-uftc8inx 2760 6 ng ng NNP cord-010092-uftc8inx 2760 7 / / SYM cord-010092-uftc8inx 2760 8 mL mL NNP cord-010092-uftc8inx 2760 9 ) ) -RRB- cord-010092-uftc8inx 2760 10 . . . cord-010092-uftc8inx 2761 1 222 222 CD cord-010092-uftc8inx 2761 2 procedures procedure NNS cord-010092-uftc8inx 2761 3 ( ( -LRB- cord-010092-uftc8inx 2761 4 WBph wbph NN cord-010092-uftc8inx 2761 5 n n NN cord-010092-uftc8inx 2761 6 = = SYM cord-010092-uftc8inx 2761 7 146 146 CD cord-010092-uftc8inx 2761 8 , , , cord-010092-uftc8inx 2761 9 2RBCaph 2rbcaph JJ cord-010092-uftc8inx 2761 10 n n NN cord-010092-uftc8inx 2761 11 = = SYM cord-010092-uftc8inx 2761 12 76 76 CD cord-010092-uftc8inx 2761 13 ) ) -RRB- cord-010092-uftc8inx 2761 14 were be VBD cord-010092-uftc8inx 2761 15 completed complete VBN cord-010092-uftc8inx 2761 16 ; ; : cord-010092-uftc8inx 2761 17 9 9 CD cord-010092-uftc8inx 2761 18 were be VBD cord-010092-uftc8inx 2761 19 interrupted interrupt VBN cord-010092-uftc8inx 2761 20 ( ( -LRB- cord-010092-uftc8inx 2761 21 local local JJ cord-010092-uftc8inx 2761 22 hematoma hematoma NN cord-010092-uftc8inx 2761 23 , , , cord-010092-uftc8inx 2761 24 insufficient insufficient JJ cord-010092-uftc8inx 2761 25 flow flow NN cord-010092-uftc8inx 2761 26 ) ) -RRB- cord-010092-uftc8inx 2761 27 ; ; . cord-010092-uftc8inx 2762 1 35 35 CD cord-010092-uftc8inx 2762 2 ( ( -LRB- cord-010092-uftc8inx 2762 3 16 16 CD cord-010092-uftc8inx 2762 4 WBph WBph NNP cord-010092-uftc8inx 2762 5 , , , cord-010092-uftc8inx 2762 6 19 19 CD cord-010092-uftc8inx 2762 7 2RBCaph 2rbcaph CD cord-010092-uftc8inx 2762 8 ) ) -RRB- cord-010092-uftc8inx 2762 9 were be VBD cord-010092-uftc8inx 2762 10 postponed postpone VBN cord-010092-uftc8inx 2762 11 because because IN cord-010092-uftc8inx 2762 12 of of IN cord-010092-uftc8inx 2762 13 low low JJ cord-010092-uftc8inx 2762 14 Hb Hb NNP cord-010092-uftc8inx 2762 15 and and CC cord-010092-uftc8inx 2762 16 15 15 CD cord-010092-uftc8inx 2762 17 for for IN cord-010092-uftc8inx 2762 18 non non JJ cord-010092-uftc8inx 2762 19 medical medical JJ cord-010092-uftc8inx 2762 20 reasons reason NNS cord-010092-uftc8inx 2762 21 . . . cord-010092-uftc8inx 2763 1 There there EX cord-010092-uftc8inx 2763 2 were be VBD cord-010092-uftc8inx 2763 3 2 2 CD cord-010092-uftc8inx 2763 4 drop drop NN cord-010092-uftc8inx 2763 5 - - HYPH cord-010092-uftc8inx 2763 6 outs out NNS cord-010092-uftc8inx 2763 7 in in IN cord-010092-uftc8inx 2763 8 the the DT cord-010092-uftc8inx 2763 9 WBph WBph NNP cord-010092-uftc8inx 2763 10 arm arm NN cord-010092-uftc8inx 2763 11 due due IN cord-010092-uftc8inx 2763 12 to to IN cord-010092-uftc8inx 2763 13 depression depression NN cord-010092-uftc8inx 2763 14 and and CC cord-010092-uftc8inx 2763 15 poor poor JJ cord-010092-uftc8inx 2763 16 compliance compliance NN cord-010092-uftc8inx 2763 17 , , , cord-010092-uftc8inx 2763 18 respectively respectively RB cord-010092-uftc8inx 2763 19 . . . cord-010092-uftc8inx 2764 1 Anemia anemia NN cord-010092-uftc8inx 2764 2 ( ( -LRB- cord-010092-uftc8inx 2764 3 Hb Hb NNP cord-010092-uftc8inx 2764 4 < < XX cord-010092-uftc8inx 2764 5 130 130 CD cord-010092-uftc8inx 2764 6 g g NN cord-010092-uftc8inx 2764 7 / / SYM cord-010092-uftc8inx 2764 8 L l NN cord-010092-uftc8inx 2764 9 in in IN cord-010092-uftc8inx 2764 10 males male NNS cord-010092-uftc8inx 2764 11 , , , cord-010092-uftc8inx 2764 12 < < XX cord-010092-uftc8inx 2764 13 120 120 CD cord-010092-uftc8inx 2764 14 g g NN cord-010092-uftc8inx 2764 15 / / SYM cord-010092-uftc8inx 2764 16 L l NN cord-010092-uftc8inx 2764 17 in in IN cord-010092-uftc8inx 2764 18 females female NNS cord-010092-uftc8inx 2764 19 ) ) -RRB- cord-010092-uftc8inx 2764 20 occurred occur VBD cord-010092-uftc8inx 2764 21 after after IN cord-010092-uftc8inx 2764 22 15 15 CD cord-010092-uftc8inx 2764 23 visits visit NNS cord-010092-uftc8inx 2764 24 in in IN cord-010092-uftc8inx 2764 25 8 8 CD cord-010092-uftc8inx 2764 26 WBph WBph NNP cord-010092-uftc8inx 2764 27 subjects subject NNS cord-010092-uftc8inx 2764 28 and and CC cord-010092-uftc8inx 2764 29 after after IN cord-010092-uftc8inx 2764 30 5 5 CD cord-010092-uftc8inx 2764 31 visits visit NNS cord-010092-uftc8inx 2764 32 in in IN cord-010092-uftc8inx 2764 33 3 3 CD cord-010092-uftc8inx 2764 34 2RBCaph 2rbcaph JJ cord-010092-uftc8inx 2764 35 subjects subject NNS cord-010092-uftc8inx 2764 36 . . . cord-010092-uftc8inx 2765 1 Fatigue fatigue NN cord-010092-uftc8inx 2765 2 was be VBD cord-010092-uftc8inx 2765 3 reported report VBN cord-010092-uftc8inx 2765 4 after after IN cord-010092-uftc8inx 2765 5 37 37 CD cord-010092-uftc8inx 2765 6 phlebotomies phlebotomy NNS cord-010092-uftc8inx 2765 7 and and CC cord-010092-uftc8inx 2765 8 31 31 CD cord-010092-uftc8inx 2765 9 aphereses apherese NNS cord-010092-uftc8inx 2765 10 . . . cord-010092-uftc8inx 2766 1 Only only RB cord-010092-uftc8inx 2766 2 5 5 CD cord-010092-uftc8inx 2766 3 participants participant NNS cord-010092-uftc8inx 2766 4 ( ( -LRB- cord-010092-uftc8inx 2766 5 17 17 CD cord-010092-uftc8inx 2766 6 % % NN cord-010092-uftc8inx 2766 7 ) ) -RRB- cord-010092-uftc8inx 2766 8 completed complete VBD cord-010092-uftc8inx 2766 9 the the DT cord-010092-uftc8inx 2766 10 study study NN cord-010092-uftc8inx 2766 11 per per IN cord-010092-uftc8inx 2766 12 protocol protocol NN cord-010092-uftc8inx 2766 13 . . . cord-010092-uftc8inx 2767 1 136 136 CD cord-010092-uftc8inx 2767 2 blood blood NN cord-010092-uftc8inx 2767 3 components component NNS cord-010092-uftc8inx 2767 4 ( ( -LRB- cord-010092-uftc8inx 2767 5 94 94 CD cord-010092-uftc8inx 2767 6 RBC RBC NNP cord-010092-uftc8inx 2767 7 concentrates concentrate VBZ cord-010092-uftc8inx 2767 8 and and CC cord-010092-uftc8inx 2767 9 42 42 CD cord-010092-uftc8inx 2767 10 plasma plasma NN cord-010092-uftc8inx 2767 11 units unit NNS cord-010092-uftc8inx 2767 12 ) ) -RRB- cord-010092-uftc8inx 2767 13 for for IN cord-010092-uftc8inx 2767 14 transfusion transfusion NN cord-010092-uftc8inx 2767 15 were be VBD cord-010092-uftc8inx 2767 16 obtained obtain VBN cord-010092-uftc8inx 2767 17 . . . cord-010092-uftc8inx 2768 1 Overall overall RB cord-010092-uftc8inx 2768 2 , , , cord-010092-uftc8inx 2768 3 a a DT cord-010092-uftc8inx 2768 4 median median NN cord-010092-uftc8inx 2768 5 of of IN cord-010092-uftc8inx 2768 6 7.5 7.5 CD cord-010092-uftc8inx 2768 7 WBph WBph NNP cord-010092-uftc8inx 2768 8 ( ( -LRB- cord-010092-uftc8inx 2768 9 IQR IQR NNP cord-010092-uftc8inx 2768 10 6.2 6.2 CD cord-010092-uftc8inx 2768 11 - - HYPH cord-010092-uftc8inx 2768 12 9.8 9.8 CD cord-010092-uftc8inx 2768 13 ) ) -RRB- cord-010092-uftc8inx 2768 14 was be VBD cord-010092-uftc8inx 2768 15 needed need VBN cord-010092-uftc8inx 2768 16 to to TO cord-010092-uftc8inx 2768 17 reach reach VB cord-010092-uftc8inx 2768 18 SF SF NNP cord-010092-uftc8inx 2768 19 < < XX cord-010092-uftc8inx 2768 20 100 100 CD cord-010092-uftc8inx 2768 21 ng ng NNP cord-010092-uftc8inx 2768 22 / / SYM cord-010092-uftc8inx 2768 23 mL ml NN cord-010092-uftc8inx 2768 24 , , , cord-010092-uftc8inx 2768 25 corresponding correspond VBG cord-010092-uftc8inx 2768 26 to to IN cord-010092-uftc8inx 2768 27 1.8 1.8 CD cord-010092-uftc8inx 2768 28 times time NNS cord-010092-uftc8inx 2768 29 of of IN cord-010092-uftc8inx 2768 30 2RBCaph 2rbcaph CD cord-010092-uftc8inx 2768 31 ( ( -LRB- cord-010092-uftc8inx 2768 32 median median NN cord-010092-uftc8inx 2768 33 4.0 4.0 CD cord-010092-uftc8inx 2768 34 , , , cord-010092-uftc8inx 2768 35 IQR IQR NNP cord-010092-uftc8inx 2768 36 3.0 3.0 NNP cord-010092-uftc8inx 2768 37 - - HYPH cord-010092-uftc8inx 2768 38 5.8 5.8 CD cord-010092-uftc8inx 2768 39 ) ) -RRB- cord-010092-uftc8inx 2769 1 ( ( -LRB- cord-010092-uftc8inx 2769 2 P p NN cord-010092-uftc8inx 2769 3 = = SYM cord-010092-uftc8inx 2769 4 0.0001 0.0001 CD cord-010092-uftc8inx 2769 5 ) ) -RRB- cord-010092-uftc8inx 2769 6 . . . cord-010092-uftc8inx 2770 1 Analyzing analyze VBG cord-010092-uftc8inx 2770 2 separately separately RB cord-010092-uftc8inx 2770 3 p. p. NN cord-010092-uftc8inx 2771 1 C282 C282 NNP cord-010092-uftc8inx 2771 2 / / SYM cord-010092-uftc8inx 2771 3 p p NN cord-010092-uftc8inx 2771 4 . . . cord-010092-uftc8inx 2772 1 C282Y C282Y NNP cord-010092-uftc8inx 2772 2 and and CC cord-010092-uftc8inx 2772 3 p. p. NN cord-010092-uftc8inx 2773 1 C282Y C282Y NNP cord-010092-uftc8inx 2773 2 / / SYM cord-010092-uftc8inx 2773 3 p p NN cord-010092-uftc8inx 2773 4 . . . cord-010092-uftc8inx 2774 1 H63D H63D NNP cord-010092-uftc8inx 2774 2 carriers carrier NNS cord-010092-uftc8inx 2774 3 , , , cord-010092-uftc8inx 2774 4 the the DT cord-010092-uftc8inx 2774 5 relation relation NN cord-010092-uftc8inx 2774 6 WBph WBph NNP cord-010092-uftc8inx 2774 7 to to IN cord-010092-uftc8inx 2774 8 2RBCaph 2rbcaph CD cord-010092-uftc8inx 2774 9 was be VBD cord-010092-uftc8inx 2774 10 1.6 1.6 CD cord-010092-uftc8inx 2774 11 and and CC cord-010092-uftc8inx 2774 12 1.8 1.8 CD cord-010092-uftc8inx 2774 13 , , , cord-010092-uftc8inx 2774 14 respectively respectively RB cord-010092-uftc8inx 2774 15 . . . cord-010092-uftc8inx 2775 1 Treatment treatment NN cord-010092-uftc8inx 2775 2 arm arm NN cord-010092-uftc8inx 2775 3 and and CC cord-010092-uftc8inx 2775 4 HFE HFE NNP cord-010092-uftc8inx 2775 5 mutation mutation NN cord-010092-uftc8inx 2775 6 were be VBD cord-010092-uftc8inx 2775 7 the the DT cord-010092-uftc8inx 2775 8 covariates covariate NNS cord-010092-uftc8inx 2775 9 with with IN cord-010092-uftc8inx 2775 10 significant significant JJ cord-010092-uftc8inx 2775 11 effect effect NN cord-010092-uftc8inx 2775 12 on on IN cord-010092-uftc8inx 2775 13 the the DT cord-010092-uftc8inx 2775 14 primary primary JJ cord-010092-uftc8inx 2775 15 endpoint endpoint NN cord-010092-uftc8inx 2775 16 ( ( -LRB- cord-010092-uftc8inx 2775 17 P p NN cord-010092-uftc8inx 2775 18 = = SYM cord-010092-uftc8inx 2775 19 0.0001 0.0001 CD cord-010092-uftc8inx 2775 20 and and CC cord-010092-uftc8inx 2775 21 0.007 0.007 CD cord-010092-uftc8inx 2775 22 , , , cord-010092-uftc8inx 2775 23 respectively respectively RB cord-010092-uftc8inx 2775 24 ) ) -RRB- cord-010092-uftc8inx 2775 25 . . . cord-010092-uftc8inx 2776 1 Summary Summary NNP cord-010092-uftc8inx 2776 2 / / SYM cord-010092-uftc8inx 2776 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 2776 4 : : : cord-010092-uftc8inx 2777 1 2RBCaph 2RBCaph NNP cord-010092-uftc8inx 2777 2 is be VBZ cord-010092-uftc8inx 2777 3 more more RBR cord-010092-uftc8inx 2777 4 efficient efficient JJ cord-010092-uftc8inx 2777 5 than than IN cord-010092-uftc8inx 2777 6 WBph WBph NNP cord-010092-uftc8inx 2777 7 for for IN cord-010092-uftc8inx 2777 8 iron iron NN cord-010092-uftc8inx 2777 9 depletion depletion NN cord-010092-uftc8inx 2777 10 in in IN cord-010092-uftc8inx 2777 11 healthy healthy JJ cord-010092-uftc8inx 2777 12 subjects subject NNS cord-010092-uftc8inx 2777 13 with with IN cord-010092-uftc8inx 2777 14 HH HH NNP cord-010092-uftc8inx 2777 15 or or CC cord-010092-uftc8inx 2777 16 other other JJ cord-010092-uftc8inx 2777 17 HFE HFE NNP cord-010092-uftc8inx 2777 18 mutations mutation NNS cord-010092-uftc8inx 2777 19 and and CC cord-010092-uftc8inx 2777 20 moderate moderate JJ cord-010092-uftc8inx 2777 21 hyperferritinemia hyperferritinemia NN cord-010092-uftc8inx 2777 22 . . . cord-010092-uftc8inx 2778 1 Intensive intensive JJ cord-010092-uftc8inx 2778 2 treatment treatment NN cord-010092-uftc8inx 2778 3 schedules schedule NNS cord-010092-uftc8inx 2778 4 , , , cord-010092-uftc8inx 2778 5 generally generally RB cord-010092-uftc8inx 2778 6 recommended recommend VBN cord-010092-uftc8inx 2778 7 for for IN cord-010092-uftc8inx 2778 8 HH HH NNP cord-010092-uftc8inx 2778 9 , , , cord-010092-uftc8inx 2778 10 are be VBP cord-010092-uftc8inx 2778 11 difficult difficult JJ cord-010092-uftc8inx 2778 12 to to TO cord-010092-uftc8inx 2778 13 keep keep VB cord-010092-uftc8inx 2778 14 because because IN cord-010092-uftc8inx 2778 15 of of IN cord-010092-uftc8inx 2778 16 Hb Hb NNP cord-010092-uftc8inx 2778 17 drop drop NN cord-010092-uftc8inx 2778 18 and and CC cord-010092-uftc8inx 2778 19 compliance compliance NN cord-010092-uftc8inx 2778 20 . . . cord-010092-uftc8inx 2779 1 Less less RBR cord-010092-uftc8inx 2779 2 intensive intensive JJ cord-010092-uftc8inx 2779 3 treatment treatment NN cord-010092-uftc8inx 2779 4 in in IN cord-010092-uftc8inx 2779 5 asymptomatic asymptomatic JJ cord-010092-uftc8inx 2779 6 individuals individual NNS cord-010092-uftc8inx 2779 7 with with IN cord-010092-uftc8inx 2779 8 HH HH NNP cord-010092-uftc8inx 2779 9 and and CC cord-010092-uftc8inx 2779 10 their -PRON- PRP$ cord-010092-uftc8inx 2779 11 inclusion inclusion NN cord-010092-uftc8inx 2779 12 in in IN cord-010092-uftc8inx 2779 13 blood blood NN cord-010092-uftc8inx 2779 14 donation donation NN cord-010092-uftc8inx 2779 15 would would MD cord-010092-uftc8inx 2779 16 avoid avoid VB cord-010092-uftc8inx 2779 17 negative negative JJ cord-010092-uftc8inx 2779 18 effects effect NNS cord-010092-uftc8inx 2779 19 on on IN cord-010092-uftc8inx 2779 20 quality quality NN cord-010092-uftc8inx 2779 21 of of IN cord-010092-uftc8inx 2779 22 life life NN cord-010092-uftc8inx 2779 23 and and CC cord-010092-uftc8inx 2779 24 benefit benefit VB cord-010092-uftc8inx 2779 25 blood blood NN cord-010092-uftc8inx 2779 26 collection collection NN cord-010092-uftc8inx 2779 27 centers center NNS cord-010092-uftc8inx 2779 28 in in IN cord-010092-uftc8inx 2779 29 the the DT cord-010092-uftc8inx 2779 30 long long JJ cord-010092-uftc8inx 2779 31 term term NN cord-010092-uftc8inx 2779 32 . . . cord-010092-uftc8inx 2780 1 Background background NN cord-010092-uftc8inx 2780 2 : : : cord-010092-uftc8inx 2781 1 Serum serum NN cord-010092-uftc8inx 2781 2 ferritin ferritin NN cord-010092-uftc8inx 2781 3 ( ( -LRB- cord-010092-uftc8inx 2781 4 SF SF NNP cord-010092-uftc8inx 2781 5 ) ) -RRB- cord-010092-uftc8inx 2781 6 measurements measurement NNS cord-010092-uftc8inx 2781 7 in in IN cord-010092-uftc8inx 2781 8 whole whole JJ cord-010092-uftc8inx 2781 9 blood blood NN cord-010092-uftc8inx 2781 10 ( ( -LRB- cord-010092-uftc8inx 2781 11 WB WB NNP cord-010092-uftc8inx 2781 12 ) ) -RRB- cord-010092-uftc8inx 2781 13 donors donor NNS cord-010092-uftc8inx 2781 14 demonstrated demonstrate VBD cord-010092-uftc8inx 2781 15 that that IN cord-010092-uftc8inx 2781 16 female female JJ cord-010092-uftc8inx 2781 17 sex sex NN cord-010092-uftc8inx 2781 18 and and CC cord-010092-uftc8inx 2781 19 intensity intensity NN cord-010092-uftc8inx 2781 20 of of IN cord-010092-uftc8inx 2781 21 donation donation NN cord-010092-uftc8inx 2781 22 are be VBP cord-010092-uftc8inx 2781 23 major major JJ cord-010092-uftc8inx 2781 24 risk risk NN cord-010092-uftc8inx 2781 25 factors factor NNS cord-010092-uftc8inx 2781 26 for for IN cord-010092-uftc8inx 2781 27 iron iron NN cord-010092-uftc8inx 2781 28 deficiency deficiency NN cord-010092-uftc8inx 2781 29 . . . cord-010092-uftc8inx 2782 1 Approximately approximately RB cord-010092-uftc8inx 2782 2 200 200 CD cord-010092-uftc8inx 2782 3 mL ml NN cord-010092-uftc8inx 2782 4 red red JJ cord-010092-uftc8inx 2782 5 blood blood NN cord-010092-uftc8inx 2782 6 cells cell NNS cord-010092-uftc8inx 2782 7 ( ( -LRB- cord-010092-uftc8inx 2782 8 RBC RBC NNP cord-010092-uftc8inx 2782 9 ) ) -RRB- cord-010092-uftc8inx 2782 10 and and CC cord-010092-uftc8inx 2783 1 200 200 CD cord-010092-uftc8inx 2783 2 - - SYM cord-010092-uftc8inx 2783 3 240 240 CD cord-010092-uftc8inx 2783 4 mg mg NNP cord-010092-uftc8inx 2783 5 iron iron NN cord-010092-uftc8inx 2783 6 are be VBP cord-010092-uftc8inx 2783 7 lost lose VBN cord-010092-uftc8inx 2783 8 with with IN cord-010092-uftc8inx 2783 9 WB WB NNP cord-010092-uftc8inx 2783 10 donation donation NN cord-010092-uftc8inx 2783 11 . . . cord-010092-uftc8inx 2784 1 Double double JJ cord-010092-uftc8inx 2784 2 unit unit NN cord-010092-uftc8inx 2784 3 RBC RBC NNP cord-010092-uftc8inx 2784 4 ( ( -LRB- cord-010092-uftc8inx 2784 5 2RBC 2RBC NNP cord-010092-uftc8inx 2784 6 ) ) -RRB- cord-010092-uftc8inx 2784 7 collections collection NNS cord-010092-uftc8inx 2784 8 of of IN cord-010092-uftc8inx 2784 9 360 360 CD cord-010092-uftc8inx 2784 10 mL ml NN cord-010092-uftc8inx 2784 11 ( ( -LRB- cord-010092-uftc8inx 2784 12 ca ca NN cord-010092-uftc8inx 2784 13 . . . cord-010092-uftc8inx 2785 1 40 40 CD cord-010092-uftc8inx 2785 2 mL ml NN cord-010092-uftc8inx 2785 3 less less JJR cord-010092-uftc8inx 2785 4 than than IN cord-010092-uftc8inx 2785 5 the the DT cord-010092-uftc8inx 2785 6 RBC RBC NNP cord-010092-uftc8inx 2785 7 amount amount NN cord-010092-uftc8inx 2785 8 of of IN cord-010092-uftc8inx 2785 9 two two CD cord-010092-uftc8inx 2785 10 WB WB NNP cord-010092-uftc8inx 2785 11 donations donation NNS cord-010092-uftc8inx 2785 12 ) ) -RRB- cord-010092-uftc8inx 2785 13 lead lead VBP cord-010092-uftc8inx 2785 14 to to IN cord-010092-uftc8inx 2785 15 a a DT cord-010092-uftc8inx 2785 16 loss loss NN cord-010092-uftc8inx 2785 17 of of IN cord-010092-uftc8inx 2785 18 about about RB cord-010092-uftc8inx 2785 19 400 400 CD cord-010092-uftc8inx 2785 20 mg mg NN cord-010092-uftc8inx 2785 21 iron iron NN cord-010092-uftc8inx 2785 22 . . . cord-010092-uftc8inx 2786 1 In in IN cord-010092-uftc8inx 2786 2 Switzerland Switzerland NNP cord-010092-uftc8inx 2786 3 , , , cord-010092-uftc8inx 2786 4 the the DT cord-010092-uftc8inx 2786 5 maximal maximal NN cord-010092-uftc8inx 2786 6 allowed allow VBN cord-010092-uftc8inx 2786 7 donation donation NN cord-010092-uftc8inx 2786 8 frequency frequency NN cord-010092-uftc8inx 2786 9 for for IN cord-010092-uftc8inx 2786 10 male male JJ cord-010092-uftc8inx 2786 11 donors donor NNS cord-010092-uftc8inx 2786 12 is be VBZ cord-010092-uftc8inx 2786 13 once once RB cord-010092-uftc8inx 2786 14 every every DT cord-010092-uftc8inx 2786 15 6 6 CD cord-010092-uftc8inx 2786 16 months month NNS cord-010092-uftc8inx 2786 17 for for IN cord-010092-uftc8inx 2786 18 2RBC 2rbc CD cord-010092-uftc8inx 2786 19 and and CC cord-010092-uftc8inx 2786 20 once once RB cord-010092-uftc8inx 2786 21 every every DT cord-010092-uftc8inx 2786 22 3 3 CD cord-010092-uftc8inx 2786 23 months month NNS cord-010092-uftc8inx 2786 24 for for IN cord-010092-uftc8inx 2786 25 WB WB NNP cord-010092-uftc8inx 2786 26 donation donation NN cord-010092-uftc8inx 2786 27 . . . cord-010092-uftc8inx 2787 1 Aims aim VBZ cord-010092-uftc8inx 2787 2 : : : cord-010092-uftc8inx 2787 3 To to TO cord-010092-uftc8inx 2787 4 describe describe VB cord-010092-uftc8inx 2787 5 and and CC cord-010092-uftc8inx 2787 6 compare compare VB cord-010092-uftc8inx 2787 7 the the DT cord-010092-uftc8inx 2787 8 course course NN cord-010092-uftc8inx 2787 9 of of IN cord-010092-uftc8inx 2787 10 hemoglobin hemoglobin NN cord-010092-uftc8inx 2787 11 ( ( -LRB- cord-010092-uftc8inx 2787 12 Hb Hb NNP cord-010092-uftc8inx 2787 13 ) ) -RRB- cord-010092-uftc8inx 2787 14 and and CC cord-010092-uftc8inx 2787 15 SF SF NNP cord-010092-uftc8inx 2787 16 in in IN cord-010092-uftc8inx 2787 17 male male JJ cord-010092-uftc8inx 2787 18 subjects subject NNS cord-010092-uftc8inx 2787 19 donating donate VBG cord-010092-uftc8inx 2787 20 WB WB NNP cord-010092-uftc8inx 2787 21 and and CC cord-010092-uftc8inx 2787 22 2RBC 2rbc CD cord-010092-uftc8inx 2787 23 at at IN cord-010092-uftc8inx 2787 24 our -PRON- PRP$ cord-010092-uftc8inx 2787 25 institution institution NN cord-010092-uftc8inx 2787 26 . . . cord-010092-uftc8inx 2788 1 Methods method NNS cord-010092-uftc8inx 2788 2 : : : cord-010092-uftc8inx 2789 1 We -PRON- PRP cord-010092-uftc8inx 2789 2 included include VBD cord-010092-uftc8inx 2789 3 294 294 CD cord-010092-uftc8inx 2789 4 WB WB NNP cord-010092-uftc8inx 2789 5 and and CC cord-010092-uftc8inx 2789 6 151 151 CD cord-010092-uftc8inx 2789 7 2RBC 2rbc CD cord-010092-uftc8inx 2789 8 donors donor NNS cord-010092-uftc8inx 2789 9 ( ( -LRB- cord-010092-uftc8inx 2789 10 n n NN cord-010092-uftc8inx 2789 11 = = SYM cord-010092-uftc8inx 2789 12 445 445 CD cord-010092-uftc8inx 2789 13 ) ) -RRB- cord-010092-uftc8inx 2789 14 who who WP cord-010092-uftc8inx 2789 15 donated donate VBD cord-010092-uftc8inx 2789 16 with with IN cord-010092-uftc8inx 2789 17 the the DT cord-010092-uftc8inx 2789 18 maximal maximal JJ cord-010092-uftc8inx 2789 19 allowed allow VBN cord-010092-uftc8inx 2789 20 donation donation NN cord-010092-uftc8inx 2789 21 frequency frequency NN cord-010092-uftc8inx 2789 22 over over IN cord-010092-uftc8inx 2789 23 48 48 CD cord-010092-uftc8inx 2789 24 months month NNS cord-010092-uftc8inx 2789 25 between between IN cord-010092-uftc8inx 2789 26 2008 2008 CD cord-010092-uftc8inx 2789 27 and and CC cord-010092-uftc8inx 2789 28 2013 2013 CD cord-010092-uftc8inx 2789 29 , , , cord-010092-uftc8inx 2789 30 yielding yield VBG cord-010092-uftc8inx 2789 31 4,704 4,704 CD cord-010092-uftc8inx 2789 32 WB WB NNP cord-010092-uftc8inx 2789 33 and and CC cord-010092-uftc8inx 2789 34 1,208 1,208 CD cord-010092-uftc8inx 2789 35 2RBC 2rbc CD cord-010092-uftc8inx 2789 36 donations donation NNS cord-010092-uftc8inx 2789 37 . . . cord-010092-uftc8inx 2790 1 We -PRON- PRP cord-010092-uftc8inx 2790 2 excluded exclude VBD cord-010092-uftc8inx 2790 3 subjects subject NNS cord-010092-uftc8inx 2790 4 with with IN cord-010092-uftc8inx 2790 5 hyperferritinemia hyperferritinemia NNP cord-010092-uftc8inx 2790 6 and and CC cord-010092-uftc8inx 2790 7 known know VBN cord-010092-uftc8inx 2790 8 HFE HFE NNP cord-010092-uftc8inx 2790 9 mutations mutation NNS cord-010092-uftc8inx 2790 10 . . . cord-010092-uftc8inx 2791 1 Hb Hb NNP cord-010092-uftc8inx 2791 2 limits limit NNS cord-010092-uftc8inx 2791 3 were be VBD cord-010092-uftc8inx 2791 4 135 135 CD cord-010092-uftc8inx 2791 5 g g NN cord-010092-uftc8inx 2791 6 / / SYM cord-010092-uftc8inx 2791 7 L L NNP cord-010092-uftc8inx 2791 8 for for IN cord-010092-uftc8inx 2791 9 WB WB NNP cord-010092-uftc8inx 2791 10 and and CC cord-010092-uftc8inx 2791 11 140 140 CD cord-010092-uftc8inx 2791 12 g g NN cord-010092-uftc8inx 2791 13 / / SYM cord-010092-uftc8inx 2791 14 L l NN cord-010092-uftc8inx 2791 15 for for IN cord-010092-uftc8inx 2791 16 2RBC 2RBC NNP cord-010092-uftc8inx 2791 17 donation donation NN cord-010092-uftc8inx 2791 18 . . . cord-010092-uftc8inx 2792 1 With with IN cord-010092-uftc8inx 2792 2 2RBC 2rbc CD cord-010092-uftc8inx 2793 1 apheresis apheresis NN cord-010092-uftc8inx 2793 2 360 360 CD cord-010092-uftc8inx 2793 3 mL mL NNP cord-010092-uftc8inx 2793 4 RBC RBC NNP cord-010092-uftc8inx 2793 5 were be VBD cord-010092-uftc8inx 2793 6 collected collect VBN cord-010092-uftc8inx 2793 7 . . . cord-010092-uftc8inx 2794 1 SF SF NNP cord-010092-uftc8inx 2794 2 was be VBD cord-010092-uftc8inx 2794 3 measured measure VBN cord-010092-uftc8inx 2794 4 on on IN cord-010092-uftc8inx 2794 5 a a DT cord-010092-uftc8inx 2794 6 predonation predonation NN cord-010092-uftc8inx 2794 7 serum serum NN cord-010092-uftc8inx 2794 8 sample sample NN cord-010092-uftc8inx 2794 9 ; ; : cord-010092-uftc8inx 2794 10 Hb Hb NNP cord-010092-uftc8inx 2794 11 was be VBD cord-010092-uftc8inx 2794 12 determined determine VBN cord-010092-uftc8inx 2794 13 from from IN cord-010092-uftc8inx 2794 14 finger finger NN cord-010092-uftc8inx 2794 15 prick prick NN cord-010092-uftc8inx 2794 16 samples sample NNS cord-010092-uftc8inx 2794 17 . . . cord-010092-uftc8inx 2795 1 The the DT cord-010092-uftc8inx 2795 2 donors donor NNS cord-010092-uftc8inx 2795 3 received receive VBD cord-010092-uftc8inx 2795 4 no no DT cord-010092-uftc8inx 2795 5 iron iron NN cord-010092-uftc8inx 2795 6 substitution substitution NN cord-010092-uftc8inx 2795 7 . . . cord-010092-uftc8inx 2796 1 We -PRON- PRP cord-010092-uftc8inx 2796 2 used use VBD cord-010092-uftc8inx 2796 3 generalized generalized JJ cord-010092-uftc8inx 2796 4 estimating estimate VBG cord-010092-uftc8inx 2796 5 equation equation NN cord-010092-uftc8inx 2796 6 models model NNS cord-010092-uftc8inx 2796 7 for for IN cord-010092-uftc8inx 2796 8 Hb Hb NNP cord-010092-uftc8inx 2796 9 and and CC cord-010092-uftc8inx 2796 10 SF SF NNP cord-010092-uftc8inx 2796 11 trajectories trajectory NNS cord-010092-uftc8inx 2796 12 . . . cord-010092-uftc8inx 2797 1 Results result NNS cord-010092-uftc8inx 2797 2 : : : cord-010092-uftc8inx 2798 1 Mean mean JJ cord-010092-uftc8inx 2798 2 age age NN cord-010092-uftc8inx 2798 3 at at IN cord-010092-uftc8inx 2798 4 the the DT cord-010092-uftc8inx 2798 5 first first JJ cord-010092-uftc8inx 2798 6 blood blood NN cord-010092-uftc8inx 2798 7 donation donation NN cord-010092-uftc8inx 2798 8 was be VBD cord-010092-uftc8inx 2798 9 53 53 CD cord-010092-uftc8inx 2798 10 ( ( -LRB- cord-010092-uftc8inx 2798 11 WB WB NNP cord-010092-uftc8inx 2798 12 ) ) -RRB- cord-010092-uftc8inx 2798 13 and and CC cord-010092-uftc8inx 2798 14 48 48 CD cord-010092-uftc8inx 2798 15 years year NNS cord-010092-uftc8inx 2798 16 ( ( -LRB- cord-010092-uftc8inx 2798 17 2RBC 2rbc LS cord-010092-uftc8inx 2798 18 ) ) -RRB- cord-010092-uftc8inx 2798 19 , , , cord-010092-uftc8inx 2798 20 respectively respectively RB cord-010092-uftc8inx 2798 21 . . . cord-010092-uftc8inx 2799 1 At at IN cord-010092-uftc8inx 2799 2 the the DT cord-010092-uftc8inx 2799 3 first first JJ cord-010092-uftc8inx 2799 4 donation donation NN cord-010092-uftc8inx 2799 5 , , , cord-010092-uftc8inx 2799 6 mean mean JJ cord-010092-uftc8inx 2799 7 Hb Hb NNP cord-010092-uftc8inx 2799 8 was be VBD cord-010092-uftc8inx 2799 9 153 153 CD cord-010092-uftc8inx 2799 10 g g NN cord-010092-uftc8inx 2799 11 / / SYM cord-010092-uftc8inx 2799 12 L L NNP cord-010092-uftc8inx 2799 13 ( ( -LRB- cord-010092-uftc8inx 2799 14 SD SD NNP cord-010092-uftc8inx 2799 15 13 13 CD cord-010092-uftc8inx 2799 16 ) ) -RRB- cord-010092-uftc8inx 2799 17 in in IN cord-010092-uftc8inx 2799 18 WB WB NNP cord-010092-uftc8inx 2799 19 and and CC cord-010092-uftc8inx 2799 20 159 159 CD cord-010092-uftc8inx 2799 21 g g NN cord-010092-uftc8inx 2799 22 / / SYM cord-010092-uftc8inx 2799 23 L L NNP cord-010092-uftc8inx 2799 24 ( ( -LRB- cord-010092-uftc8inx 2799 25 SD SD NNP cord-010092-uftc8inx 2799 26 8) 8) NN cord-010092-uftc8inx 2799 27 in in IN cord-010092-uftc8inx 2799 28 2RBC 2rbc CD cord-010092-uftc8inx 2799 29 donors donor NNS cord-010092-uftc8inx 2799 30 ; ; : cord-010092-uftc8inx 2799 31 mean mean VB cord-010092-uftc8inx 2799 32 SF SF NNP cord-010092-uftc8inx 2799 33 was be VBD cord-010092-uftc8inx 2799 34 44 44 CD cord-010092-uftc8inx 2800 1 ( ( -LRB- cord-010092-uftc8inx 2800 2 SD SD NNP cord-010092-uftc8inx 2800 3 52 52 CD cord-010092-uftc8inx 2800 4 ) ) -RRB- cord-010092-uftc8inx 2800 5 and and CC cord-010092-uftc8inx 2800 6 73 73 CD cord-010092-uftc8inx 2800 7 lg lg NNP cord-010092-uftc8inx 2800 8 / / SYM cord-010092-uftc8inx 2800 9 L L NNP cord-010092-uftc8inx 2800 10 ( ( -LRB- cord-010092-uftc8inx 2800 11 SD SD NNP cord-010092-uftc8inx 2800 12 56 56 CD cord-010092-uftc8inx 2800 13 ) ) -RRB- cord-010092-uftc8inx 2800 14 , , , cord-010092-uftc8inx 2800 15 respectively respectively RB cord-010092-uftc8inx 2800 16 . . . cord-010092-uftc8inx 2801 1 On on IN cord-010092-uftc8inx 2801 2 average average JJ cord-010092-uftc8inx 2801 3 , , , cord-010092-uftc8inx 2801 4 Hb Hb NNP cord-010092-uftc8inx 2801 5 and and CC cord-010092-uftc8inx 2801 6 SF SF NNP cord-010092-uftc8inx 2801 7 were be VBD cord-010092-uftc8inx 2801 8 higher high JJR cord-010092-uftc8inx 2801 9 in in IN cord-010092-uftc8inx 2801 10 2RBC 2rbc CD cord-010092-uftc8inx 2801 11 donors donor NNS cord-010092-uftc8inx 2801 12 ( ( -LRB- cord-010092-uftc8inx 2801 13 5.1 5.1 CD cord-010092-uftc8inx 2801 14 g g NN cord-010092-uftc8inx 2801 15 / / SYM cord-010092-uftc8inx 2801 16 L L NNP cord-010092-uftc8inx 2801 17 and and CC cord-010092-uftc8inx 2801 18 26 26 CD cord-010092-uftc8inx 2801 19 lg lg NNP cord-010092-uftc8inx 2801 20 / / SYM cord-010092-uftc8inx 2801 21 L L NNP cord-010092-uftc8inx 2801 22 , , , cord-010092-uftc8inx 2801 23 respectively respectively RB cord-010092-uftc8inx 2801 24 ; ; : cord-010092-uftc8inx 2801 25 P p NN cord-010092-uftc8inx 2801 26 < < XX cord-010092-uftc8inx 2801 27 0.001 0.001 CD cord-010092-uftc8inx 2801 28 ) ) -RRB- cord-010092-uftc8inx 2801 29 . . . cord-010092-uftc8inx 2802 1 There there EX cord-010092-uftc8inx 2802 2 were be VBD cord-010092-uftc8inx 2802 3 137 137 CD cord-010092-uftc8inx 2802 4 subjects subject NNS cord-010092-uftc8inx 2802 5 with with IN cord-010092-uftc8inx 2802 6 SF SF NNP cord-010092-uftc8inx 2802 7 < < XX cord-010092-uftc8inx 2802 8 30 30 CD cord-010092-uftc8inx 2802 9 lg lg NNP cord-010092-uftc8inx 2802 10 / / SYM cord-010092-uftc8inx 2802 11 L L NNP cord-010092-uftc8inx 2802 12 in in IN cord-010092-uftc8inx 2802 13 WB WB NNP cord-010092-uftc8inx 2802 14 and and CC cord-010092-uftc8inx 2802 15 19 19 CD cord-010092-uftc8inx 2802 16 in in IN cord-010092-uftc8inx 2802 17 2RBC 2rbc CD cord-010092-uftc8inx 2802 18 group group NN cord-010092-uftc8inx 2802 19 , , , cord-010092-uftc8inx 2802 20 and and CC cord-010092-uftc8inx 2802 21 85 85 CD cord-010092-uftc8inx 2802 22 with with IN cord-010092-uftc8inx 2802 23 SF SF NNP cord-010092-uftc8inx 2802 24 < < XX cord-010092-uftc8inx 2802 25 50 50 CD cord-010092-uftc8inx 2802 26 lg lg NNP cord-010092-uftc8inx 2802 27 / / SYM cord-010092-uftc8inx 2802 28 L L NNP cord-010092-uftc8inx 2802 29 ( ( -LRB- cord-010092-uftc8inx 2802 30 but but CC cord-010092-uftc8inx 2802 31 > > XX cord-010092-uftc8inx 2802 32 30 30 CD cord-010092-uftc8inx 2802 33 lg lg NNP cord-010092-uftc8inx 2802 34 / / SYM cord-010092-uftc8inx 2802 35 L L NNP cord-010092-uftc8inx 2802 36 ) ) -RRB- cord-010092-uftc8inx 2802 37 and and CC cord-010092-uftc8inx 2802 38 40 40 CD cord-010092-uftc8inx 2802 39 , , , cord-010092-uftc8inx 2802 40 respectively respectively RB cord-010092-uftc8inx 2802 41 . . . cord-010092-uftc8inx 2803 1 In in IN cord-010092-uftc8inx 2803 2 2RBC 2rbc CD cord-010092-uftc8inx 2803 3 donors donor NNS cord-010092-uftc8inx 2803 4 , , , cord-010092-uftc8inx 2803 5 between between IN cord-010092-uftc8inx 2803 6 the the DT cord-010092-uftc8inx 2803 7 first first JJ cord-010092-uftc8inx 2803 8 and and CC cord-010092-uftc8inx 2803 9 the the DT cord-010092-uftc8inx 2803 10 last last JJ cord-010092-uftc8inx 2803 11 donation donation NN cord-010092-uftc8inx 2803 12 , , , cord-010092-uftc8inx 2803 13 mean mean JJ cord-010092-uftc8inx 2803 14 Hb Hb NNP cord-010092-uftc8inx 2803 15 declined decline VBD cord-010092-uftc8inx 2803 16 from from IN cord-010092-uftc8inx 2803 17 159 159 CD cord-010092-uftc8inx 2803 18 g g NN cord-010092-uftc8inx 2803 19 / / SYM cord-010092-uftc8inx 2803 20 L l NN cord-010092-uftc8inx 2803 21 to to IN cord-010092-uftc8inx 2803 22 157 157 CD cord-010092-uftc8inx 2803 23 g g NN cord-010092-uftc8inx 2803 24 / / SYM cord-010092-uftc8inx 2803 25 L l NN cord-010092-uftc8inx 2803 26 ( ( -LRB- cord-010092-uftc8inx 2803 27 P p NN cord-010092-uftc8inx 2803 28 < < XX cord-010092-uftc8inx 2803 29 0.05 0.05 CD cord-010092-uftc8inx 2803 30 ) ) -RRB- cord-010092-uftc8inx 2803 31 and and CC cord-010092-uftc8inx 2803 32 mean mean VB cord-010092-uftc8inx 2803 33 SF SF NNP cord-010092-uftc8inx 2803 34 from from IN cord-010092-uftc8inx 2803 35 73 73 CD cord-010092-uftc8inx 2803 36 lg lg NNP cord-010092-uftc8inx 2803 37 / / SYM cord-010092-uftc8inx 2803 38 L L NNP cord-010092-uftc8inx 2803 39 to to IN cord-010092-uftc8inx 2803 40 66 66 CD cord-010092-uftc8inx 2803 41 lg lg NNP cord-010092-uftc8inx 2803 42 / / SYM cord-010092-uftc8inx 2803 43 L L NNP cord-010092-uftc8inx 2803 44 ( ( -LRB- cord-010092-uftc8inx 2803 45 ns ns NNP cord-010092-uftc8inx 2803 46 ) ) -RRB- cord-010092-uftc8inx 2803 47 . . . cord-010092-uftc8inx 2804 1 In in IN cord-010092-uftc8inx 2804 2 WB WB NNP cord-010092-uftc8inx 2804 3 donors donor NNS cord-010092-uftc8inx 2804 4 , , , cord-010092-uftc8inx 2804 5 mean mean JJ cord-010092-uftc8inx 2804 6 Hb Hb NNP cord-010092-uftc8inx 2804 7 dropped drop VBD cord-010092-uftc8inx 2804 8 from from IN cord-010092-uftc8inx 2804 9 153 153 CD cord-010092-uftc8inx 2804 10 g g NN cord-010092-uftc8inx 2804 11 / / SYM cord-010092-uftc8inx 2804 12 L l NN cord-010092-uftc8inx 2804 13 to to IN cord-010092-uftc8inx 2804 14 152 152 CD cord-010092-uftc8inx 2804 15 g g NN cord-010092-uftc8inx 2804 16 / / SYM cord-010092-uftc8inx 2804 17 L l NN cord-010092-uftc8inx 2804 18 ( ( -LRB- cord-010092-uftc8inx 2804 19 P p NN cord-010092-uftc8inx 2804 20 < < XX cord-010092-uftc8inx 2804 21 0.05 0.05 CD cord-010092-uftc8inx 2804 22 ) ) -RRB- cord-010092-uftc8inx 2804 23 and and CC cord-010092-uftc8inx 2804 24 SF SF NNP cord-010092-uftc8inx 2804 25 from from IN cord-010092-uftc8inx 2804 26 44 44 CD cord-010092-uftc8inx 2804 27 lg lg NNP cord-010092-uftc8inx 2804 28 / / SYM cord-010092-uftc8inx 2804 29 L L NNP cord-010092-uftc8inx 2804 30 to to IN cord-010092-uftc8inx 2804 31 35 35 CD cord-010092-uftc8inx 2804 32 lg lg NNP cord-010092-uftc8inx 2804 33 / / SYM cord-010092-uftc8inx 2804 34 L L NNP cord-010092-uftc8inx 2804 35 ( ( -LRB- cord-010092-uftc8inx 2804 36 P p NN cord-010092-uftc8inx 2804 37 < < XX cord-010092-uftc8inx 2804 38 0.001 0.001 CD cord-010092-uftc8inx 2804 39 ) ) -RRB- cord-010092-uftc8inx 2804 40 . . . cord-010092-uftc8inx 2805 1 Similar similar JJ cord-010092-uftc8inx 2805 2 results result NNS cord-010092-uftc8inx 2805 3 were be VBD cord-010092-uftc8inx 2805 4 found find VBN cord-010092-uftc8inx 2805 5 when when WRB cord-010092-uftc8inx 2805 6 adjusting adjust VBG cord-010092-uftc8inx 2805 7 for for IN cord-010092-uftc8inx 2805 8 age age NN cord-010092-uftc8inx 2805 9 and and CC cord-010092-uftc8inx 2805 10 season season NN cord-010092-uftc8inx 2805 11 . . . cord-010092-uftc8inx 2806 1 Hb Hb NNP cord-010092-uftc8inx 2806 2 values value NNS cord-010092-uftc8inx 2806 3 dropped drop VBD cord-010092-uftc8inx 2806 4 from from IN cord-010092-uftc8inx 2806 5 baseline baseline NN cord-010092-uftc8inx 2806 6 until until IN cord-010092-uftc8inx 2806 7 the the DT cord-010092-uftc8inx 2806 8 11 11 CD cord-010092-uftc8inx 2806 9 th th XX cord-010092-uftc8inx 2806 10 donation donation NN cord-010092-uftc8inx 2806 11 for for IN cord-010092-uftc8inx 2806 12 WB WB NNP cord-010092-uftc8inx 2806 13 donors donor NNS cord-010092-uftc8inx 2806 14 and and CC cord-010092-uftc8inx 2806 15 until until IN cord-010092-uftc8inx 2806 16 the the DT cord-010092-uftc8inx 2806 17 4 4 CD cord-010092-uftc8inx 2806 18 th th XX cord-010092-uftc8inx 2806 19 donation donation NN cord-010092-uftc8inx 2806 20 for for IN cord-010092-uftc8inx 2806 21 2RBC 2rbc CD cord-010092-uftc8inx 2806 22 donors donor NNS cord-010092-uftc8inx 2806 23 with with IN cord-010092-uftc8inx 2806 24 an an DT cord-010092-uftc8inx 2806 25 upward upward JJ cord-010092-uftc8inx 2806 26 trend trend NN cord-010092-uftc8inx 2806 27 thereafter thereafter RB cord-010092-uftc8inx 2806 28 . . . cord-010092-uftc8inx 2807 1 In in IN cord-010092-uftc8inx 2807 2 both both DT cord-010092-uftc8inx 2807 3 groups group NNS cord-010092-uftc8inx 2807 4 , , , cord-010092-uftc8inx 2807 5 no no DT cord-010092-uftc8inx 2807 6 Hb Hb NNP cord-010092-uftc8inx 2807 7 value value NN cord-010092-uftc8inx 2807 8 below below IN cord-010092-uftc8inx 2807 9 the the DT cord-010092-uftc8inx 2807 10 limits limit NNS cord-010092-uftc8inx 2807 11 of of IN cord-010092-uftc8inx 2807 12 blood blood NN cord-010092-uftc8inx 2807 13 donation donation NN cord-010092-uftc8inx 2807 14 and and CC cord-010092-uftc8inx 2807 15 no no DT cord-010092-uftc8inx 2807 16 anemia anemia NN cord-010092-uftc8inx 2807 17 were be VBD cord-010092-uftc8inx 2807 18 observed observe VBN cord-010092-uftc8inx 2807 19 . . . cord-010092-uftc8inx 2808 1 SF SF NNP cord-010092-uftc8inx 2808 2 reached reach VBD cord-010092-uftc8inx 2808 3 a a DT cord-010092-uftc8inx 2808 4 nadir nadir NN cord-010092-uftc8inx 2808 5 at at IN cord-010092-uftc8inx 2808 6 the the DT cord-010092-uftc8inx 2808 7 4 4 CD cord-010092-uftc8inx 2808 8 th th NN cord-010092-uftc8inx 2808 9 donation donation NN cord-010092-uftc8inx 2808 10 in in IN cord-010092-uftc8inx 2808 11 both both DT cord-010092-uftc8inx 2808 12 WB WB NNP cord-010092-uftc8inx 2808 13 and and CC cord-010092-uftc8inx 2808 14 2RBC 2rbc CD cord-010092-uftc8inx 2808 15 donors donor NNS cord-010092-uftc8inx 2808 16 ( ( -LRB- cord-010092-uftc8inx 2808 17 37 37 CD cord-010092-uftc8inx 2808 18 lg lg NNP cord-010092-uftc8inx 2808 19 / / SYM cord-010092-uftc8inx 2808 20 L L NNP cord-010092-uftc8inx 2808 21 and and CC cord-010092-uftc8inx 2808 22 60 60 CD cord-010092-uftc8inx 2808 23 lg lg NNP cord-010092-uftc8inx 2808 24 / / SYM cord-010092-uftc8inx 2808 25 L L NNP cord-010092-uftc8inx 2808 26 ) ) -RRB- cord-010092-uftc8inx 2808 27 and and CC cord-010092-uftc8inx 2808 28 increased increase VBD cord-010092-uftc8inx 2808 29 thereafter thereafter RB cord-010092-uftc8inx 2808 30 in in IN cord-010092-uftc8inx 2808 31 2RBC 2rbc CD cord-010092-uftc8inx 2808 32 donors donor NNS cord-010092-uftc8inx 2808 33 . . . cord-010092-uftc8inx 2809 1 In in IN cord-010092-uftc8inx 2809 2 WB WB NNP cord-010092-uftc8inx 2809 3 donors donor NNS cord-010092-uftc8inx 2809 4 , , , cord-010092-uftc8inx 2809 5 SF SF NNP cord-010092-uftc8inx 2809 6 followed follow VBD cord-010092-uftc8inx 2809 7 a a DT cord-010092-uftc8inx 2809 8 parabolic parabolic JJ cord-010092-uftc8inx 2809 9 trend trend NN cord-010092-uftc8inx 2809 10 that that WDT cord-010092-uftc8inx 2809 11 peaked peak VBD cord-010092-uftc8inx 2809 12 at at IN cord-010092-uftc8inx 2809 13 the the DT cord-010092-uftc8inx 2809 14 10 10 CD cord-010092-uftc8inx 2809 15 th th XX cord-010092-uftc8inx 2809 16 donation donation NN cord-010092-uftc8inx 2809 17 , , , cord-010092-uftc8inx 2809 18 and and CC cord-010092-uftc8inx 2809 19 then then RB cord-010092-uftc8inx 2809 20 declined decline VBD cord-010092-uftc8inx 2809 21 until until IN cord-010092-uftc8inx 2809 22 the the DT cord-010092-uftc8inx 2809 23 last last JJ cord-010092-uftc8inx 2809 24 donation donation NN cord-010092-uftc8inx 2809 25 . . . cord-010092-uftc8inx 2810 1 Summary Summary NNP cord-010092-uftc8inx 2810 2 / / SYM cord-010092-uftc8inx 2810 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 2810 4 : : : cord-010092-uftc8inx 2811 1 The the DT cord-010092-uftc8inx 2811 2 maximal maximal NN cord-010092-uftc8inx 2811 3 allowed allow VBD cord-010092-uftc8inx 2811 4 blood blood NN cord-010092-uftc8inx 2811 5 donation donation NN cord-010092-uftc8inx 2811 6 frequency frequency NN cord-010092-uftc8inx 2811 7 for for IN cord-010092-uftc8inx 2811 8 WB WB NNP cord-010092-uftc8inx 2811 9 and and CC cord-010092-uftc8inx 2811 10 2RBC 2RBC NNP cord-010092-uftc8inx 2812 1 male male JJ cord-010092-uftc8inx 2812 2 donors donor NNS cord-010092-uftc8inx 2812 3 in in IN cord-010092-uftc8inx 2812 4 Switzerland Switzerland NNP cord-010092-uftc8inx 2812 5 is be VBZ cord-010092-uftc8inx 2812 6 not not RB cord-010092-uftc8inx 2812 7 only only RB cord-010092-uftc8inx 2812 8 protective protective JJ cord-010092-uftc8inx 2812 9 for for IN cord-010092-uftc8inx 2812 10 the the DT cord-010092-uftc8inx 2812 11 development development NN cord-010092-uftc8inx 2812 12 of of IN cord-010092-uftc8inx 2812 13 anemia anemia NN cord-010092-uftc8inx 2812 14 , , , cord-010092-uftc8inx 2812 15 but but CC cord-010092-uftc8inx 2812 16 also also RB cord-010092-uftc8inx 2812 17 for for IN cord-010092-uftc8inx 2812 18 deferral deferral NN cord-010092-uftc8inx 2812 19 of of IN cord-010092-uftc8inx 2812 20 blood blood NN cord-010092-uftc8inx 2812 21 donors donor NNS cord-010092-uftc8inx 2812 22 because because IN cord-010092-uftc8inx 2812 23 of of IN cord-010092-uftc8inx 2812 24 low low JJ cord-010092-uftc8inx 2812 25 Hb Hb NNP cord-010092-uftc8inx 2812 26 . . . cord-010092-uftc8inx 2813 1 This this DT cord-010092-uftc8inx 2813 2 was be VBD cord-010092-uftc8inx 2813 3 observed observe VBN cord-010092-uftc8inx 2813 4 even even RB cord-010092-uftc8inx 2813 5 in in IN cord-010092-uftc8inx 2813 6 subjects subject NNS cord-010092-uftc8inx 2813 7 with with IN cord-010092-uftc8inx 2813 8 low low JJ cord-010092-uftc8inx 2813 9 SF SF NNP cord-010092-uftc8inx 2813 10 at at IN cord-010092-uftc8inx 2813 11 baseline baseline NN cord-010092-uftc8inx 2813 12 . . . cord-010092-uftc8inx 2814 1 Background background NN cord-010092-uftc8inx 2814 2 : : : cord-010092-uftc8inx 2815 1 Granulocyte Granulocyte NNP cord-010092-uftc8inx 2815 2 concentrate concentrate VBP cord-010092-uftc8inx 2815 3 transfusion transfusion NN cord-010092-uftc8inx 2815 4 is be VBZ cord-010092-uftc8inx 2815 5 a a DT cord-010092-uftc8inx 2815 6 potentially potentially RB cord-010092-uftc8inx 2815 7 lifesaving lifesaving JJ cord-010092-uftc8inx 2815 8 option option NN cord-010092-uftc8inx 2815 9 for for IN cord-010092-uftc8inx 2815 10 patients patient NNS cord-010092-uftc8inx 2815 11 without without IN cord-010092-uftc8inx 2815 12 functional functional JJ cord-010092-uftc8inx 2815 13 neutrophils neutrophil NNS cord-010092-uftc8inx 2815 14 . . . cord-010092-uftc8inx 2816 1 However however RB cord-010092-uftc8inx 2816 2 , , , cord-010092-uftc8inx 2816 3 recent recent JJ cord-010092-uftc8inx 2816 4 studies study NNS cord-010092-uftc8inx 2816 5 have have VBP cord-010092-uftc8inx 2816 6 failed fail VBN cord-010092-uftc8inx 2816 7 to to TO cord-010092-uftc8inx 2816 8 demonstrate demonstrate VB cord-010092-uftc8inx 2816 9 the the DT cord-010092-uftc8inx 2816 10 anticipated anticipate VBN cord-010092-uftc8inx 2816 11 clinical clinical JJ cord-010092-uftc8inx 2816 12 effectiveness effectiveness NN cord-010092-uftc8inx 2816 13 of of IN cord-010092-uftc8inx 2816 14 this this DT cord-010092-uftc8inx 2816 15 procedure procedure NN cord-010092-uftc8inx 2816 16 . . . cord-010092-uftc8inx 2817 1 Granulocyte Granulocyte NNP cord-010092-uftc8inx 2817 2 concentrates concentrate NNS cord-010092-uftc8inx 2817 3 are be VBP cord-010092-uftc8inx 2817 4 manufactured manufacture VBN cord-010092-uftc8inx 2817 5 using use VBG cord-010092-uftc8inx 2817 6 sedimentation sedimentation NN cord-010092-uftc8inx 2817 7 agents agent NNS cord-010092-uftc8inx 2817 8 to to TO cord-010092-uftc8inx 2817 9 separate separate VB cord-010092-uftc8inx 2817 10 granulocytes granulocyte NNS cord-010092-uftc8inx 2817 11 from from IN cord-010092-uftc8inx 2817 12 red red JJ cord-010092-uftc8inx 2817 13 blood blood NN cord-010092-uftc8inx 2817 14 cells cell NNS cord-010092-uftc8inx 2817 15 and and CC cord-010092-uftc8inx 2817 16 enhance enhance VB cord-010092-uftc8inx 2817 17 granulocyte granulocyte NN cord-010092-uftc8inx 2817 18 collection collection NN cord-010092-uftc8inx 2817 19 efficiency efficiency NN cord-010092-uftc8inx 2817 20 . . . cord-010092-uftc8inx 2818 1 High high JJ cord-010092-uftc8inx 2818 2 - - HYPH cord-010092-uftc8inx 2818 3 molecularweight molecularweight NN cord-010092-uftc8inx 2818 4 hydroxyethyl hydroxyethyl NN cord-010092-uftc8inx 2818 5 starch starch NN cord-010092-uftc8inx 2818 6 ( ( -LRB- cord-010092-uftc8inx 2818 7 HES HES NNP cord-010092-uftc8inx 2818 8 ) ) -RRB- cord-010092-uftc8inx 2818 9 is be VBZ cord-010092-uftc8inx 2818 10 most most RBS cord-010092-uftc8inx 2818 11 commonly commonly RB cord-010092-uftc8inx 2818 12 used use VBN cord-010092-uftc8inx 2818 13 for for IN cord-010092-uftc8inx 2818 14 this this DT cord-010092-uftc8inx 2818 15 . . . cord-010092-uftc8inx 2819 1 However however RB cord-010092-uftc8inx 2819 2 , , , cord-010092-uftc8inx 2819 3 authorities authority NNS cord-010092-uftc8inx 2819 4 recently recently RB cord-010092-uftc8inx 2819 5 restricted restrict VBD cord-010092-uftc8inx 2819 6 the the DT cord-010092-uftc8inx 2819 7 use use NN cord-010092-uftc8inx 2819 8 of of IN cord-010092-uftc8inx 2819 9 HES HES NNP cord-010092-uftc8inx 2819 10 due due JJ cord-010092-uftc8inx 2819 11 to to IN cord-010092-uftc8inx 2819 12 its -PRON- PRP$ cord-010092-uftc8inx 2819 13 unfavorable unfavorable JJ cord-010092-uftc8inx 2819 14 risk risk NN cord-010092-uftc8inx 2819 15 - - HYPH cord-010092-uftc8inx 2819 16 benefit benefit NN cord-010092-uftc8inx 2819 17 - - HYPH cord-010092-uftc8inx 2819 18 profile profile NN cord-010092-uftc8inx 2819 19 . . . cord-010092-uftc8inx 2820 1 Modified modify VBN cord-010092-uftc8inx 2820 2 fluid fluid NN cord-010092-uftc8inx 2820 3 gelatin gelatin NN cord-010092-uftc8inx 2820 4 ( ( -LRB- cord-010092-uftc8inx 2820 5 MFG MFG NNP cord-010092-uftc8inx 2820 6 ) ) -RRB- cord-010092-uftc8inx 2820 7 is be VBZ cord-010092-uftc8inx 2820 8 an an DT cord-010092-uftc8inx 2820 9 already already RB cord-010092-uftc8inx 2820 10 used use VBN cord-010092-uftc8inx 2820 11 alternative alternative JJ cord-010092-uftc8inx 2820 12 sedimentation sedimentation NN cord-010092-uftc8inx 2820 13 agent agent NN cord-010092-uftc8inx 2820 14 . . . cord-010092-uftc8inx 2821 1 As as IN cord-010092-uftc8inx 2821 2 the the DT cord-010092-uftc8inx 2821 3 granulocyte granulocyte NN cord-010092-uftc8inx 2821 4 product product NN cord-010092-uftc8inx 2821 5 contains contain VBZ cord-010092-uftc8inx 2821 6 these these DT cord-010092-uftc8inx 2821 7 substances substance NNS cord-010092-uftc8inx 2821 8 , , , cord-010092-uftc8inx 2821 9 any any DT cord-010092-uftc8inx 2821 10 impact impact NN cord-010092-uftc8inx 2821 11 of of IN cord-010092-uftc8inx 2821 12 the the DT cord-010092-uftc8inx 2821 13 sedimentation sedimentation NN cord-010092-uftc8inx 2821 14 agent agent NN cord-010092-uftc8inx 2821 15 on on IN cord-010092-uftc8inx 2821 16 granulocyte granulocyte NN cord-010092-uftc8inx 2821 17 function function NN cord-010092-uftc8inx 2821 18 may may MD cord-010092-uftc8inx 2821 19 affect affect VB cord-010092-uftc8inx 2821 20 the the DT cord-010092-uftc8inx 2821 21 clinical clinical JJ cord-010092-uftc8inx 2821 22 effectiveness effectiveness NN cord-010092-uftc8inx 2821 23 of of IN cord-010092-uftc8inx 2821 24 granulocyte granulocyte NN cord-010092-uftc8inx 2821 25 transfusion transfusion NN cord-010092-uftc8inx 2821 26 . . . cord-010092-uftc8inx 2822 1 Aims aim VBZ cord-010092-uftc8inx 2822 2 : : : cord-010092-uftc8inx 2822 3 We -PRON- PRP cord-010092-uftc8inx 2822 4 tested test VBD cord-010092-uftc8inx 2822 5 the the DT cord-010092-uftc8inx 2822 6 hypothesis hypothesis NN cord-010092-uftc8inx 2822 7 that that IN cord-010092-uftc8inx 2822 8 MFG MFG NNP cord-010092-uftc8inx 2822 9 is be VBZ cord-010092-uftc8inx 2822 10 not not RB cord-010092-uftc8inx 2822 11 inferior inferior JJ cord-010092-uftc8inx 2822 12 to to IN cord-010092-uftc8inx 2822 13 HES HES NNP cord-010092-uftc8inx 2822 14 in in IN cord-010092-uftc8inx 2822 15 terms term NNS cord-010092-uftc8inx 2822 16 of of IN cord-010092-uftc8inx 2822 17 the the DT cord-010092-uftc8inx 2822 18 functionality functionality NN cord-010092-uftc8inx 2822 19 and and CC cord-010092-uftc8inx 2822 20 viability viability NN cord-010092-uftc8inx 2822 21 of of IN cord-010092-uftc8inx 2822 22 granulocytes granulocyte NNS cord-010092-uftc8inx 2822 23 . . . cord-010092-uftc8inx 2823 1 Methods method NNS cord-010092-uftc8inx 2823 2 : : : cord-010092-uftc8inx 2824 1 Granulocytes granulocyte NNS cord-010092-uftc8inx 2824 2 from from IN cord-010092-uftc8inx 2824 3 ten ten CD cord-010092-uftc8inx 2824 4 healthy healthy JJ cord-010092-uftc8inx 2824 5 donors donor NNS cord-010092-uftc8inx 2824 6 were be VBD cord-010092-uftc8inx 2824 7 isolated isolate VBN cord-010092-uftc8inx 2824 8 , , , cord-010092-uftc8inx 2824 9 aliquoted aliquote VBN cord-010092-uftc8inx 2824 10 and and CC cord-010092-uftc8inx 2824 11 incubated incubate VBN cord-010092-uftc8inx 2824 12 in in IN cord-010092-uftc8inx 2824 13 parallel parallel NN cord-010092-uftc8inx 2824 14 for for IN cord-010092-uftc8inx 2824 15 2 2 CD cord-010092-uftc8inx 2824 16 hours hour NNS cord-010092-uftc8inx 2824 17 with with IN cord-010092-uftc8inx 2824 18 either either DT cord-010092-uftc8inx 2824 19 0 0 CD cord-010092-uftc8inx 2824 20 % % NN cord-010092-uftc8inx 2824 21 ( ( -LRB- cord-010092-uftc8inx 2824 22 control control NN cord-010092-uftc8inx 2824 23 ) ) -RRB- cord-010092-uftc8inx 2824 24 , , , cord-010092-uftc8inx 2824 25 7.5 7.5 CD cord-010092-uftc8inx 2824 26 % % NN cord-010092-uftc8inx 2824 27 , , , cord-010092-uftc8inx 2824 28 15 15 CD cord-010092-uftc8inx 2824 29 % % NN cord-010092-uftc8inx 2824 30 or or CC cord-010092-uftc8inx 2824 31 30 30 CD cord-010092-uftc8inx 2824 32 % % NN cord-010092-uftc8inx 2824 33 MFG MFG NNP cord-010092-uftc8inx 2824 34 ( ( -LRB- cord-010092-uftc8inx 2824 35 Gelafundin Gelafundin NNP cord-010092-uftc8inx 2824 36 4 4 CD cord-010092-uftc8inx 2824 37 % % NN cord-010092-uftc8inx 2824 38 , , , cord-010092-uftc8inx 2824 39 B. B. NNP cord-010092-uftc8inx 2824 40 Braun Braun NNP cord-010092-uftc8inx 2824 41 Melsungen Melsungen NNP cord-010092-uftc8inx 2824 42 AG AG NNP cord-010092-uftc8inx 2824 43 ) ) -RRB- cord-010092-uftc8inx 2824 44 or or CC cord-010092-uftc8inx 2824 45 HES HES NNP cord-010092-uftc8inx 2824 46 ( ( -LRB- cord-010092-uftc8inx 2824 47 Hespan Hespan NNP cord-010092-uftc8inx 2824 48 6%/450/0.7 6%/450/0.7 NNP cord-010092-uftc8inx 2824 49 , , , cord-010092-uftc8inx 2824 50 B. B. NNP cord-010092-uftc8inx 2824 51 Braun Braun NNP cord-010092-uftc8inx 2824 52 Medical Medical NNP cord-010092-uftc8inx 2824 53 Inc. Inc. NNP cord-010092-uftc8inx 2824 54 ) ) -RRB- cord-010092-uftc8inx 2824 55 , , , cord-010092-uftc8inx 2824 56 respectively respectively RB cord-010092-uftc8inx 2824 57 , , , cord-010092-uftc8inx 2824 58 and and CC cord-010092-uftc8inx 2824 59 granulocyte granulocyte NN cord-010092-uftc8inx 2824 60 migration migration NN cord-010092-uftc8inx 2824 61 , , , cord-010092-uftc8inx 2824 62 chemotaxis chemotaxis NN cord-010092-uftc8inx 2824 63 , , , cord-010092-uftc8inx 2824 64 reactive reactive JJ cord-010092-uftc8inx 2824 65 oxygen oxygen NN cord-010092-uftc8inx 2824 66 species specie NNS cord-010092-uftc8inx 2824 67 ( ( -LRB- cord-010092-uftc8inx 2824 68 ROS ROS NNP cord-010092-uftc8inx 2824 69 ) ) -RRB- cord-010092-uftc8inx 2824 70 production production NN cord-010092-uftc8inx 2824 71 , , , cord-010092-uftc8inx 2824 72 neutrophil neutrophil NN cord-010092-uftc8inx 2824 73 extracellular extracellular JJ cord-010092-uftc8inx 2824 74 trap trap NN cord-010092-uftc8inx 2824 75 formation formation NN cord-010092-uftc8inx 2824 76 ( ( -LRB- cord-010092-uftc8inx 2824 77 NETosis NETosis NNP cord-010092-uftc8inx 2824 78 ) ) -RRB- cord-010092-uftc8inx 2824 79 , , . cord-010092-uftc8inx 2825 1 antigen antigen NN cord-010092-uftc8inx 2825 2 expression expression NN cord-010092-uftc8inx 2825 3 of of IN cord-010092-uftc8inx 2825 4 CD11b CD11b NNS cord-010092-uftc8inx 2825 5 , , , cord-010092-uftc8inx 2825 6 CD62L cd62l NN cord-010092-uftc8inx 2825 7 and and CC cord-010092-uftc8inx 2825 8 CD66b CD66b NNS cord-010092-uftc8inx 2825 9 , , , cord-010092-uftc8inx 2825 10 and and CC cord-010092-uftc8inx 2825 11 viability viability NN cord-010092-uftc8inx 2825 12 were be VBD cord-010092-uftc8inx 2825 13 subsequently subsequently RB cord-010092-uftc8inx 2825 14 investigated investigate VBN cord-010092-uftc8inx 2825 15 in in IN cord-010092-uftc8inx 2825 16 vitro vitro FW cord-010092-uftc8inx 2825 17 . . . cord-010092-uftc8inx 2826 1 Testing testing NN cord-010092-uftc8inx 2826 2 was be VBD cord-010092-uftc8inx 2826 3 performed perform VBN cord-010092-uftc8inx 2826 4 using use VBG cord-010092-uftc8inx 2826 5 live live JJ cord-010092-uftc8inx 2826 6 cell cell NN cord-010092-uftc8inx 2826 7 imaging imaging NN cord-010092-uftc8inx 2826 8 of of IN cord-010092-uftc8inx 2826 9 the the DT cord-010092-uftc8inx 2826 10 cells cell NNS cord-010092-uftc8inx 2826 11 embedded embed VBN cord-010092-uftc8inx 2826 12 into into IN cord-010092-uftc8inx 2826 13 a a DT cord-010092-uftc8inx 2826 14 collagen collagen NN cord-010092-uftc8inx 2826 15 I -PRON- PRP cord-010092-uftc8inx 2826 16 matrix matrix NN cord-010092-uftc8inx 2826 17 for for IN cord-010092-uftc8inx 2826 18 parallel parallel JJ cord-010092-uftc8inx 2826 19 testing testing NN cord-010092-uftc8inx 2826 20 of of IN cord-010092-uftc8inx 2826 21 migration migration NN cord-010092-uftc8inx 2826 22 , , , cord-010092-uftc8inx 2826 23 ROS ROS NNP cord-010092-uftc8inx 2826 24 production production NN cord-010092-uftc8inx 2826 25 and and CC cord-010092-uftc8inx 2826 26 NETosis netosis NN cord-010092-uftc8inx 2826 27 . . . cord-010092-uftc8inx 2827 1 In in IN cord-010092-uftc8inx 2827 2 addition addition NN cord-010092-uftc8inx 2827 3 , , , cord-010092-uftc8inx 2827 4 flow flow NN cord-010092-uftc8inx 2827 5 cytometric cytometric NNP cord-010092-uftc8inx 2827 6 ( ( -LRB- cord-010092-uftc8inx 2827 7 FACS FACS NNP cord-010092-uftc8inx 2827 8 ) ) -RRB- cord-010092-uftc8inx 2827 9 analysis analysis NN cord-010092-uftc8inx 2827 10 was be VBD cord-010092-uftc8inx 2827 11 utilized utilize VBN cord-010092-uftc8inx 2827 12 for for IN cord-010092-uftc8inx 2827 13 surface surface NN cord-010092-uftc8inx 2827 14 marker marker NN cord-010092-uftc8inx 2827 15 expression expression NN cord-010092-uftc8inx 2827 16 , , , cord-010092-uftc8inx 2827 17 viability viability NN cord-010092-uftc8inx 2827 18 and and CC cord-010092-uftc8inx 2827 19 respiratory respiratory JJ cord-010092-uftc8inx 2827 20 burst burst NN cord-010092-uftc8inx 2827 21 measurement measurement NN cord-010092-uftc8inx 2827 22 . . . cord-010092-uftc8inx 2828 1 Results result NNS cord-010092-uftc8inx 2828 2 : : : cord-010092-uftc8inx 2829 1 Granulocyte Granulocyte NNP cord-010092-uftc8inx 2829 2 migration migration NN cord-010092-uftc8inx 2829 3 decreased decrease VBD cord-010092-uftc8inx 2829 4 in in IN cord-010092-uftc8inx 2829 5 a a DT cord-010092-uftc8inx 2829 6 dose dose NN cord-010092-uftc8inx 2829 7 - - HYPH cord-010092-uftc8inx 2829 8 dependent dependent JJ cord-010092-uftc8inx 2829 9 manner manner NN cord-010092-uftc8inx 2829 10 in in IN cord-010092-uftc8inx 2829 11 response response NN cord-010092-uftc8inx 2829 12 to to IN cord-010092-uftc8inx 2829 13 HES HES NNP cord-010092-uftc8inx 2829 14 and and CC cord-010092-uftc8inx 2829 15 MFG MFG NNP cord-010092-uftc8inx 2829 16 . . . cord-010092-uftc8inx 2830 1 Relative relative JJ cord-010092-uftc8inx 2830 2 to to IN cord-010092-uftc8inx 2830 3 the the DT cord-010092-uftc8inx 2830 4 controls control NNS cord-010092-uftc8inx 2830 5 , , , cord-010092-uftc8inx 2830 6 all all DT cord-010092-uftc8inx 2830 7 three three CD cord-010092-uftc8inx 2830 8 concentrations concentration NNS cord-010092-uftc8inx 2830 9 of of IN cord-010092-uftc8inx 2830 10 HES HES NNP cord-010092-uftc8inx 2830 11 lowered lower VBD cord-010092-uftc8inx 2830 12 migration migration NN cord-010092-uftc8inx 2830 13 distances distance NNS cord-010092-uftc8inx 2830 14 ( ( -LRB- cord-010092-uftc8inx 2830 15 P p NN cord-010092-uftc8inx 2830 16 < < XX cord-010092-uftc8inx 2830 17 0.001 0.001 CD cord-010092-uftc8inx 2830 18 respectively respectively RB cord-010092-uftc8inx 2830 19 ) ) -RRB- cord-010092-uftc8inx 2830 20 , , , cord-010092-uftc8inx 2830 21 whereas whereas IN cord-010092-uftc8inx 2830 22 only only RB cord-010092-uftc8inx 2830 23 the the DT cord-010092-uftc8inx 2830 24 higher high JJR cord-010092-uftc8inx 2830 25 concentrations concentration NNS cord-010092-uftc8inx 2830 26 ( ( -LRB- cord-010092-uftc8inx 2830 27 15 15 CD cord-010092-uftc8inx 2830 28 % % NN cord-010092-uftc8inx 2830 29 and and CC cord-010092-uftc8inx 2830 30 30 30 CD cord-010092-uftc8inx 2830 31 % % NN cord-010092-uftc8inx 2830 32 ) ) -RRB- cord-010092-uftc8inx 2830 33 of of IN cord-010092-uftc8inx 2830 34 MFG MFG NNP cord-010092-uftc8inx 2830 35 showed show VBD cord-010092-uftc8inx 2830 36 lower low JJR cord-010092-uftc8inx 2830 37 relative relative JJ cord-010092-uftc8inx 2830 38 migration migration NN cord-010092-uftc8inx 2830 39 distances distance NNS cord-010092-uftc8inx 2830 40 ( ( -LRB- cord-010092-uftc8inx 2830 41 P p NN cord-010092-uftc8inx 2830 42 < < XX cord-010092-uftc8inx 2830 43 0.001 0.001 CD cord-010092-uftc8inx 2830 44 respectively respectively RB cord-010092-uftc8inx 2830 45 ) ) -RRB- cord-010092-uftc8inx 2830 46 . . . cord-010092-uftc8inx 2831 1 Track track NN cord-010092-uftc8inx 2831 2 straightness straightness NN cord-010092-uftc8inx 2831 3 was be VBD cord-010092-uftc8inx 2831 4 reduced reduce VBN cord-010092-uftc8inx 2831 5 with with IN cord-010092-uftc8inx 2831 6 both both DT cord-010092-uftc8inx 2831 7 sedimentation sedimentation NN cord-010092-uftc8inx 2831 8 agents agent NNS cord-010092-uftc8inx 2831 9 at at IN cord-010092-uftc8inx 2831 10 15 15 CD cord-010092-uftc8inx 2831 11 % % NN cord-010092-uftc8inx 2831 12 and and CC cord-010092-uftc8inx 2831 13 30 30 CD cord-010092-uftc8inx 2831 14 % % NN cord-010092-uftc8inx 2831 15 to to IN cord-010092-uftc8inx 2831 16 the the DT cord-010092-uftc8inx 2831 17 same same JJ cord-010092-uftc8inx 2831 18 extent extent NN cord-010092-uftc8inx 2831 19 ( ( -LRB- cord-010092-uftc8inx 2831 20 P p NN cord-010092-uftc8inx 2831 21 < < XX cord-010092-uftc8inx 2831 22 0.001 0.001 CD cord-010092-uftc8inx 2831 23 respectively respectively RB cord-010092-uftc8inx 2831 24 ) ) -RRB- cord-010092-uftc8inx 2831 25 . . . cord-010092-uftc8inx 2832 1 HES HES NNP cord-010092-uftc8inx 2832 2 resulted result VBD cord-010092-uftc8inx 2832 3 in in IN cord-010092-uftc8inx 2832 4 lower low JJR cord-010092-uftc8inx 2832 5 CD11b CD11b NNS cord-010092-uftc8inx 2832 6 expression expression NN cord-010092-uftc8inx 2832 7 ( ( -LRB- cord-010092-uftc8inx 2832 8 P p NN cord-010092-uftc8inx 2832 9 = = SYM cord-010092-uftc8inx 2832 10 0.028 0.028 CD cord-010092-uftc8inx 2832 11 ) ) -RRB- cord-010092-uftc8inx 2832 12 and and CC cord-010092-uftc8inx 2832 13 higher high JJR cord-010092-uftc8inx 2832 14 CD62L cd62l NN cord-010092-uftc8inx 2832 15 expression expression NN cord-010092-uftc8inx 2832 16 ( ( -LRB- cord-010092-uftc8inx 2832 17 P p NN cord-010092-uftc8inx 2832 18 = = SYM cord-010092-uftc8inx 2832 19 0.007 0.007 CD cord-010092-uftc8inx 2832 20 ) ) -RRB- cord-010092-uftc8inx 2832 21 compared compare VBN cord-010092-uftc8inx 2832 22 to to IN cord-010092-uftc8inx 2832 23 the the DT cord-010092-uftc8inx 2832 24 controls control NNS cord-010092-uftc8inx 2832 25 , , , cord-010092-uftc8inx 2832 26 whereas whereas IN cord-010092-uftc8inx 2832 27 the the DT cord-010092-uftc8inx 2832 28 differences difference NNS cord-010092-uftc8inx 2832 29 for for IN cord-010092-uftc8inx 2832 30 CD66b CD66b NNS cord-010092-uftc8inx 2832 31 did do VBD cord-010092-uftc8inx 2832 32 not not RB cord-010092-uftc8inx 2832 33 reach reach VB cord-010092-uftc8inx 2832 34 statistical statistical JJ cord-010092-uftc8inx 2832 35 significance significance NN cord-010092-uftc8inx 2832 36 . . . cord-010092-uftc8inx 2833 1 MFG MFG NNP cord-010092-uftc8inx 2833 2 did do VBD cord-010092-uftc8inx 2833 3 not not RB cord-010092-uftc8inx 2833 4 affect affect VB cord-010092-uftc8inx 2833 5 the the DT cord-010092-uftc8inx 2833 6 expression expression NN cord-010092-uftc8inx 2833 7 of of IN cord-010092-uftc8inx 2833 8 any any DT cord-010092-uftc8inx 2833 9 investigated investigate VBN cord-010092-uftc8inx 2833 10 surface surface NN cord-010092-uftc8inx 2833 11 antigen antigen NN cord-010092-uftc8inx 2833 12 mediating mediate VBG cord-010092-uftc8inx 2833 13 endothelial endothelial JJ cord-010092-uftc8inx 2833 14 adhesion adhesion NN cord-010092-uftc8inx 2833 15 and and CC cord-010092-uftc8inx 2833 16 transmigration transmigration NN cord-010092-uftc8inx 2833 17 in in IN cord-010092-uftc8inx 2833 18 comparison comparison NN cord-010092-uftc8inx 2833 19 to to IN cord-010092-uftc8inx 2833 20 the the DT cord-010092-uftc8inx 2833 21 controls control NNS cord-010092-uftc8inx 2833 22 . . . cord-010092-uftc8inx 2834 1 No no DT cord-010092-uftc8inx 2834 2 significant significant JJ cord-010092-uftc8inx 2834 3 differences difference NNS cord-010092-uftc8inx 2834 4 in in IN cord-010092-uftc8inx 2834 5 the the DT cord-010092-uftc8inx 2834 6 timing timing NN cord-010092-uftc8inx 2834 7 of of IN cord-010092-uftc8inx 2834 8 ROS ROS NNP cord-010092-uftc8inx 2834 9 production production NN cord-010092-uftc8inx 2834 10 or or CC cord-010092-uftc8inx 2834 11 NETosis netosis NN cord-010092-uftc8inx 2834 12 , , , cord-010092-uftc8inx 2834 13 or or CC cord-010092-uftc8inx 2834 14 in in IN cord-010092-uftc8inx 2834 15 neutrophil neutrophil NN cord-010092-uftc8inx 2834 16 viability viability NN cord-010092-uftc8inx 2834 17 or or CC cord-010092-uftc8inx 2834 18 respiratory respiratory JJ cord-010092-uftc8inx 2834 19 burst burst NN cord-010092-uftc8inx 2834 20 were be VBD cord-010092-uftc8inx 2834 21 observed observe VBN cord-010092-uftc8inx 2834 22 . . . cord-010092-uftc8inx 2835 1 Summary Summary NNP cord-010092-uftc8inx 2835 2 / / SYM cord-010092-uftc8inx 2835 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 2835 4 : : : cord-010092-uftc8inx 2836 1 These these DT cord-010092-uftc8inx 2836 2 results result NNS cord-010092-uftc8inx 2836 3 indicate indicate VBP cord-010092-uftc8inx 2836 4 that that IN cord-010092-uftc8inx 2836 5 MFG MFG NNP cord-010092-uftc8inx 2836 6 is be VBZ cord-010092-uftc8inx 2836 7 not not RB cord-010092-uftc8inx 2836 8 inferior inferior JJ cord-010092-uftc8inx 2836 9 to to IN cord-010092-uftc8inx 2836 10 HES HES NNP cord-010092-uftc8inx 2836 11 in in IN cord-010092-uftc8inx 2836 12 terms term NNS cord-010092-uftc8inx 2836 13 of of IN cord-010092-uftc8inx 2836 14 granulocyte granulocyte NN cord-010092-uftc8inx 2836 15 phenotype phenotype NN cord-010092-uftc8inx 2836 16 and and CC cord-010092-uftc8inx 2836 17 function function VB cord-010092-uftc8inx 2836 18 in in IN cord-010092-uftc8inx 2836 19 vitro vitro FW cord-010092-uftc8inx 2836 20 when when WRB cord-010092-uftc8inx 2836 21 used use VBN cord-010092-uftc8inx 2836 22 at at IN cord-010092-uftc8inx 2836 23 equal equal JJ cord-010092-uftc8inx 2836 24 concentrations concentration NNS cord-010092-uftc8inx 2836 25 , , , cord-010092-uftc8inx 2836 26 and and CC cord-010092-uftc8inx 2836 27 that that IN cord-010092-uftc8inx 2836 28 potential potential JJ cord-010092-uftc8inx 2836 29 impairment impairment NN cord-010092-uftc8inx 2836 30 of of IN cord-010092-uftc8inx 2836 31 granulocyte granulocyte NN cord-010092-uftc8inx 2836 32 function function NN cord-010092-uftc8inx 2836 33 can can MD cord-010092-uftc8inx 2836 34 occur occur VB cord-010092-uftc8inx 2836 35 with with IN cord-010092-uftc8inx 2836 36 HES HES NNP cord-010092-uftc8inx 2836 37 . . . cord-010092-uftc8inx 2837 1 Background background NN cord-010092-uftc8inx 2837 2 : : : cord-010092-uftc8inx 2838 1 Plateletpheresis plateletpheresis NN cord-010092-uftc8inx 2838 2 donation donation NN cord-010092-uftc8inx 2838 3 leads lead VBZ cord-010092-uftc8inx 2838 4 to to IN cord-010092-uftc8inx 2838 5 a a DT cord-010092-uftc8inx 2838 6 well well RB cord-010092-uftc8inx 2838 7 - - HYPH cord-010092-uftc8inx 2838 8 known know VBN cord-010092-uftc8inx 2838 9 transient transient JJ cord-010092-uftc8inx 2838 10 decrease decrease NN cord-010092-uftc8inx 2838 11 of of IN cord-010092-uftc8inx 2838 12 donor donor NN cord-010092-uftc8inx 2838 13 's 's POS cord-010092-uftc8inx 2838 14 platelets platelet NNS cord-010092-uftc8inx 2838 15 . . . cord-010092-uftc8inx 2839 1 The the DT cord-010092-uftc8inx 2839 2 question question NN cord-010092-uftc8inx 2839 3 of of IN cord-010092-uftc8inx 2839 4 long long JJ cord-010092-uftc8inx 2839 5 - - HYPH cord-010092-uftc8inx 2839 6 term term NN cord-010092-uftc8inx 2839 7 effects effect NNS cord-010092-uftc8inx 2839 8 raised raise VBN cord-010092-uftc8inx 2839 9 with with IN cord-010092-uftc8inx 2839 10 the the DT cord-010092-uftc8inx 2839 11 development development NN cord-010092-uftc8inx 2839 12 of of IN cord-010092-uftc8inx 2839 13 regular regular JJ cord-010092-uftc8inx 2839 14 donations donation NNS cord-010092-uftc8inx 2839 15 by by IN cord-010092-uftc8inx 2839 16 some some DT cord-010092-uftc8inx 2839 17 donors donor NNS cord-010092-uftc8inx 2839 18 in in IN cord-010092-uftc8inx 2839 19 order order NN cord-010092-uftc8inx 2839 20 to to TO cord-010092-uftc8inx 2839 21 satisfy satisfy VB cord-010092-uftc8inx 2839 22 a a DT cord-010092-uftc8inx 2839 23 growing grow VBG cord-010092-uftc8inx 2839 24 demand demand NN cord-010092-uftc8inx 2839 25 . . . cord-010092-uftc8inx 2840 1 A a DT cord-010092-uftc8inx 2840 2 seminal seminal JJ cord-010092-uftc8inx 2840 3 work work NN cord-010092-uftc8inx 2840 4 ( ( -LRB- cord-010092-uftc8inx 2840 5 Lazarus Lazarus NNP cord-010092-uftc8inx 2840 6 , , , cord-010092-uftc8inx 2840 7 Transfusion Transfusion NNP cord-010092-uftc8inx 2840 8 , , , cord-010092-uftc8inx 2840 9 2001 2001 CD cord-010092-uftc8inx 2840 10 ) ) -RRB- cord-010092-uftc8inx 2840 11 stated state VBD cord-010092-uftc8inx 2840 12 that that IN cord-010092-uftc8inx 2840 13 there there EX cord-010092-uftc8inx 2840 14 is be VBZ cord-010092-uftc8inx 2840 15 a a DT cord-010092-uftc8inx 2840 16 sustained sustained JJ cord-010092-uftc8inx 2840 17 thrombopenia thrombopenia NNP cord-010092-uftc8inx 2840 18 in in IN cord-010092-uftc8inx 2840 19 frequent frequent JJ cord-010092-uftc8inx 2840 20 plateletpheresis plateletpheresis NN cord-010092-uftc8inx 2840 21 donors donor NNS cord-010092-uftc8inx 2840 22 , , , cord-010092-uftc8inx 2840 23 correlated correlate VBN cord-010092-uftc8inx 2840 24 with with IN cord-010092-uftc8inx 2840 25 the the DT cord-010092-uftc8inx 2840 26 total total JJ cord-010092-uftc8inx 2840 27 number number NN cord-010092-uftc8inx 2840 28 of of IN cord-010092-uftc8inx 2840 29 donations donation NNS cord-010092-uftc8inx 2840 30 . . . cord-010092-uftc8inx 2841 1 Aims aim VBZ cord-010092-uftc8inx 2841 2 : : : cord-010092-uftc8inx 2841 3 French french JJ cord-010092-uftc8inx 2841 4 regulation regulation NN cord-010092-uftc8inx 2841 5 authorizes authorize VBZ cord-010092-uftc8inx 2841 6 up up IN cord-010092-uftc8inx 2841 7 to to TO cord-010092-uftc8inx 2841 8 12 12 CD cord-010092-uftc8inx 2841 9 plateletpheresis plateletpheresis NN cord-010092-uftc8inx 2841 10 donations donation NNS cord-010092-uftc8inx 2841 11 per per IN cord-010092-uftc8inx 2841 12 year year NN cord-010092-uftc8inx 2841 13 , , , cord-010092-uftc8inx 2841 14 with with IN cord-010092-uftc8inx 2841 15 a a DT cord-010092-uftc8inx 2841 16 minimum minimum JJ cord-010092-uftc8inx 2841 17 4 4 CD cord-010092-uftc8inx 2841 18 weeks week NNS cord-010092-uftc8inx 2841 19 interval interval NN cord-010092-uftc8inx 2841 20 between between IN cord-010092-uftc8inx 2841 21 them -PRON- PRP cord-010092-uftc8inx 2841 22 . . . cord-010092-uftc8inx 2842 1 We -PRON- PRP cord-010092-uftc8inx 2842 2 tried try VBD cord-010092-uftc8inx 2842 3 to to TO cord-010092-uftc8inx 2842 4 evaluate evaluate VB cord-010092-uftc8inx 2842 5 the the DT cord-010092-uftc8inx 2842 6 risk risk NN cord-010092-uftc8inx 2842 7 of of IN cord-010092-uftc8inx 2842 8 sustained sustained JJ cord-010092-uftc8inx 2842 9 thrombopenia thrombopenia NNP cord-010092-uftc8inx 2842 10 under under IN cord-010092-uftc8inx 2842 11 these these DT cord-010092-uftc8inx 2842 12 conditions condition NNS cord-010092-uftc8inx 2842 13 . . . cord-010092-uftc8inx 2843 1 Methods method NNS cord-010092-uftc8inx 2843 2 : : : cord-010092-uftc8inx 2843 3 We -PRON- PRP cord-010092-uftc8inx 2843 4 retrieved retrieve VBD cord-010092-uftc8inx 2843 5 all all DT cord-010092-uftc8inx 2843 6 plateletpheresis plateletpheresis NN cord-010092-uftc8inx 2843 7 donations donation NNS cord-010092-uftc8inx 2843 8 occurring occur VBG cord-010092-uftc8inx 2843 9 between between IN cord-010092-uftc8inx 2843 10 01/01/2014 01/01/2014 CD cord-010092-uftc8inx 2843 11 and and CC cord-010092-uftc8inx 2843 12 08/31/2018 08/31/2018 CD cord-010092-uftc8inx 2843 13 from from IN cord-010092-uftc8inx 2843 14 the the DT cord-010092-uftc8inx 2843 15 French french JJ cord-010092-uftc8inx 2843 16 civilian civilian JJ cord-010092-uftc8inx 2843 17 blood blood NN cord-010092-uftc8inx 2843 18 donors donor NNS cord-010092-uftc8inx 2843 19 ' ' POS cord-010092-uftc8inx 2843 20 base base NN cord-010092-uftc8inx 2843 21 and and CC cord-010092-uftc8inx 2843 22 then then RB cord-010092-uftc8inx 2843 23 selected select VBD cord-010092-uftc8inx 2843 24 a a DT cord-010092-uftc8inx 2843 25 cohort cohort NN cord-010092-uftc8inx 2843 26 of of IN cord-010092-uftc8inx 2843 27 donors donor NNS cord-010092-uftc8inx 2843 28 with with IN cord-010092-uftc8inx 2843 29 at at RB cord-010092-uftc8inx 2843 30 least least RBS cord-010092-uftc8inx 2843 31 24 24 CD cord-010092-uftc8inx 2843 32 donations donation NNS cord-010092-uftc8inx 2843 33 during during IN cord-010092-uftc8inx 2843 34 that that DT cord-010092-uftc8inx 2843 35 period period NN cord-010092-uftc8inx 2843 36 . . . cord-010092-uftc8inx 2844 1 In in IN cord-010092-uftc8inx 2844 2 order order NN cord-010092-uftc8inx 2844 3 to to TO cord-010092-uftc8inx 2844 4 minimize minimize VB cord-010092-uftc8inx 2844 5 measurement measurement NN cord-010092-uftc8inx 2844 6 errors error NNS cord-010092-uftc8inx 2844 7 , , , cord-010092-uftc8inx 2844 8 platelet platelet NN cord-010092-uftc8inx 2844 9 counts count NNS cord-010092-uftc8inx 2844 10 analysed analyse VBN cord-010092-uftc8inx 2844 11 were be VBD cord-010092-uftc8inx 2844 12 means mean NNS cord-010092-uftc8inx 2844 13 of of IN cord-010092-uftc8inx 2844 14 three three CD cord-010092-uftc8inx 2844 15 consecutive consecutive JJ cord-010092-uftc8inx 2844 16 donations donation NNS cord-010092-uftc8inx 2844 17 , , , cord-010092-uftc8inx 2844 18 i.e. i.e. FW cord-010092-uftc8inx 2844 19 8 8 CD cord-010092-uftc8inx 2844 20 measures measure NNS cord-010092-uftc8inx 2844 21 for for IN cord-010092-uftc8inx 2844 22 each each DT cord-010092-uftc8inx 2844 23 donor donor NN cord-010092-uftc8inx 2844 24 . . . cord-010092-uftc8inx 2845 1 Results result NNS cord-010092-uftc8inx 2845 2 : : : cord-010092-uftc8inx 2846 1 The the DT cord-010092-uftc8inx 2846 2 cohort cohort NN cord-010092-uftc8inx 2846 3 includes include VBZ cord-010092-uftc8inx 2846 4 2,186 2,186 CD cord-010092-uftc8inx 2846 5 donors donor NNS cord-010092-uftc8inx 2846 6 ( ( -LRB- cord-010092-uftc8inx 2846 7 384 384 CD cord-010092-uftc8inx 2846 8 women woman NNS cord-010092-uftc8inx 2846 9 and and CC cord-010092-uftc8inx 2846 10 1,802 1,802 CD cord-010092-uftc8inx 2846 11 men man NNS cord-010092-uftc8inx 2846 12 ) ) -RRB- cord-010092-uftc8inx 2846 13 . . . cord-010092-uftc8inx 2847 1 Mean mean JJ cord-010092-uftc8inx 2847 2 platelet platelet NN cord-010092-uftc8inx 2847 3 counts count NNS cord-010092-uftc8inx 2847 4 fluctuate fluctuate VBP cord-010092-uftc8inx 2847 5 between between IN cord-010092-uftc8inx 2847 6 276.4 276.4 CD cord-010092-uftc8inx 2847 7 and and CC cord-010092-uftc8inx 2847 8 278.6 278.6 CD cord-010092-uftc8inx 2847 9 platelets/ platelets/ . cord-010092-uftc8inx 2848 1 mL. mL. NNP cord-010092-uftc8inx 2848 2 Analysis Analysis NNP cord-010092-uftc8inx 2848 3 of of IN cord-010092-uftc8inx 2848 4 variance variance NN cord-010092-uftc8inx 2848 5 does do VBZ cord-010092-uftc8inx 2848 6 not not RB cord-010092-uftc8inx 2848 7 show show VB cord-010092-uftc8inx 2848 8 any any DT cord-010092-uftc8inx 2848 9 statistically statistically RB cord-010092-uftc8inx 2848 10 significant significant JJ cord-010092-uftc8inx 2848 11 difference difference NN cord-010092-uftc8inx 2848 12 ( ( -LRB- cord-010092-uftc8inx 2848 13 F f NN cord-010092-uftc8inx 2848 14 = = SYM cord-010092-uftc8inx 2848 15 0.462 0.462 CD cord-010092-uftc8inx 2848 16 ) ) -RRB- cord-010092-uftc8inx 2848 17 , , , cord-010092-uftc8inx 2848 18 even even RB cord-010092-uftc8inx 2848 19 taking take VBG cord-010092-uftc8inx 2848 20 donor donor NN cord-010092-uftc8inx 2848 21 's 's POS cord-010092-uftc8inx 2848 22 sex sex NN cord-010092-uftc8inx 2848 23 or or CC cord-010092-uftc8inx 2848 24 age age NN cord-010092-uftc8inx 2848 25 in in IN cord-010092-uftc8inx 2848 26 consideration consideration NN cord-010092-uftc8inx 2848 27 . . . cord-010092-uftc8inx 2849 1 There there EX cord-010092-uftc8inx 2849 2 is be VBZ cord-010092-uftc8inx 2849 3 no no DT cord-010092-uftc8inx 2849 4 difference difference NN cord-010092-uftc8inx 2849 5 if if IN cord-010092-uftc8inx 2849 6 we -PRON- PRP cord-010092-uftc8inx 2849 7 consider consider VBP cord-010092-uftc8inx 2849 8 the the DT cord-010092-uftc8inx 2849 9 total total JJ cord-010092-uftc8inx 2849 10 duration duration NN cord-010092-uftc8inx 2849 11 of of IN cord-010092-uftc8inx 2849 12 the the DT cord-010092-uftc8inx 2849 13 24 24 CD cord-010092-uftc8inx 2849 14 donations donation NNS cord-010092-uftc8inx 2849 15 , , , cord-010092-uftc8inx 2849 16 either either RB cord-010092-uftc8inx 2849 17 . . . cord-010092-uftc8inx 2850 1 Donors donor NNS cord-010092-uftc8inx 2850 2 with with IN cord-010092-uftc8inx 2850 3 the the DT cord-010092-uftc8inx 2850 4 lowest low JJS cord-010092-uftc8inx 2850 5 first first JJ cord-010092-uftc8inx 2850 6 counts count NNS cord-010092-uftc8inx 2850 7 show show VBP cord-010092-uftc8inx 2850 8 a a DT cord-010092-uftc8inx 2850 9 significant significant JJ cord-010092-uftc8inx 2850 10 rise rise NN cord-010092-uftc8inx 2850 11 in in IN cord-010092-uftc8inx 2850 12 subsequent subsequent JJ cord-010092-uftc8inx 2850 13 measures measure NNS cord-010092-uftc8inx 2850 14 and and CC cord-010092-uftc8inx 2850 15 donors donor NNS cord-010092-uftc8inx 2850 16 with with IN cord-010092-uftc8inx 2850 17 the the DT cord-010092-uftc8inx 2850 18 highest high JJS cord-010092-uftc8inx 2850 19 counts count NNS cord-010092-uftc8inx 2850 20 show show VBP cord-010092-uftc8inx 2850 21 a a DT cord-010092-uftc8inx 2850 22 decrease decrease NN cord-010092-uftc8inx 2850 23 trend trend NN cord-010092-uftc8inx 2850 24 , , , cord-010092-uftc8inx 2850 25 exhibiting exhibit VBG cord-010092-uftc8inx 2850 26 a a DT cord-010092-uftc8inx 2850 27 classical classical JJ cord-010092-uftc8inx 2850 28 regression regression NN cord-010092-uftc8inx 2850 29 toward toward IN cord-010092-uftc8inx 2850 30 the the DT cord-010092-uftc8inx 2850 31 mean mean NN cord-010092-uftc8inx 2850 32 . . . cord-010092-uftc8inx 2851 1 Summary Summary NNP cord-010092-uftc8inx 2851 2 / / SYM cord-010092-uftc8inx 2851 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 2851 4 : : : cord-010092-uftc8inx 2852 1 Plateletpheresis Plateletpheresis NNP cord-010092-uftc8inx 2852 2 French french JJ cord-010092-uftc8inx 2852 3 regulation regulation NN cord-010092-uftc8inx 2852 4 does do VBZ cord-010092-uftc8inx 2852 5 not not RB cord-010092-uftc8inx 2852 6 seem seem VB cord-010092-uftc8inx 2852 7 to to TO cord-010092-uftc8inx 2852 8 be be VB cord-010092-uftc8inx 2852 9 at at IN cord-010092-uftc8inx 2852 10 risk risk NN cord-010092-uftc8inx 2852 11 of of IN cord-010092-uftc8inx 2852 12 sustained sustained JJ cord-010092-uftc8inx 2852 13 donor donor NN cord-010092-uftc8inx 2852 14 thrombopenia thrombopenia NNP cord-010092-uftc8inx 2852 15 . . . cord-010092-uftc8inx 2853 1 This this DT cord-010092-uftc8inx 2853 2 conclusion conclusion NN cord-010092-uftc8inx 2853 3 is be VBZ cord-010092-uftc8inx 2853 4 in in IN cord-010092-uftc8inx 2853 5 agreement agreement NN cord-010092-uftc8inx 2853 6 with with IN cord-010092-uftc8inx 2853 7 recent recent JJ cord-010092-uftc8inx 2853 8 literature literature NN cord-010092-uftc8inx 2853 9 data datum NNS cord-010092-uftc8inx 2853 10 . . . cord-010092-uftc8inx 2854 1 The the DT cord-010092-uftc8inx 2854 2 primary primary JJ cord-010092-uftc8inx 2854 3 biological biological JJ cord-010092-uftc8inx 2854 4 role role NN cord-010092-uftc8inx 2854 5 of of IN cord-010092-uftc8inx 2854 6 the the DT cord-010092-uftc8inx 2854 7 Human Human NNP cord-010092-uftc8inx 2854 8 Leukocyte Leukocyte NNP cord-010092-uftc8inx 2854 9 Antigen Antigen NNP cord-010092-uftc8inx 2854 10 ( ( -LRB- cord-010092-uftc8inx 2854 11 HLA HLA NNP cord-010092-uftc8inx 2854 12 ) ) -RRB- cord-010092-uftc8inx 2854 13 system system NN cord-010092-uftc8inx 2854 14 is be VBZ cord-010092-uftc8inx 2854 15 the the DT cord-010092-uftc8inx 2854 16 regulation regulation NN cord-010092-uftc8inx 2854 17 of of IN cord-010092-uftc8inx 2854 18 the the DT cord-010092-uftc8inx 2854 19 immune immune JJ cord-010092-uftc8inx 2854 20 response response NN cord-010092-uftc8inx 2854 21 to to IN cord-010092-uftc8inx 2854 22 foreign foreign JJ cord-010092-uftc8inx 2854 23 antigens antigen NNS cord-010092-uftc8inx 2854 24 . . . cord-010092-uftc8inx 2855 1 Because because IN cord-010092-uftc8inx 2855 2 of of IN cord-010092-uftc8inx 2855 3 this this DT cord-010092-uftc8inx 2855 4 role role NN cord-010092-uftc8inx 2855 5 , , , cord-010092-uftc8inx 2855 6 HLA HLA NNP cord-010092-uftc8inx 2855 7 genes gene NNS cord-010092-uftc8inx 2855 8 and and CC cord-010092-uftc8inx 2855 9 molecules molecule NNS cord-010092-uftc8inx 2855 10 have have VBP cord-010092-uftc8inx 2855 11 an an DT cord-010092-uftc8inx 2855 12 important important JJ cord-010092-uftc8inx 2855 13 role role NN cord-010092-uftc8inx 2855 14 in in IN cord-010092-uftc8inx 2855 15 transplantation transplantation NN cord-010092-uftc8inx 2855 16 , , , cord-010092-uftc8inx 2855 17 etiology etiology NN cord-010092-uftc8inx 2855 18 of of IN cord-010092-uftc8inx 2855 19 many many JJ cord-010092-uftc8inx 2855 20 autoimmune autoimmune JJ cord-010092-uftc8inx 2855 21 , , , cord-010092-uftc8inx 2855 22 non non JJ cord-010092-uftc8inx 2855 23 - - JJ cord-010092-uftc8inx 2855 24 autoimmune autoimmune JJ cord-010092-uftc8inx 2855 25 and and CC cord-010092-uftc8inx 2855 26 infection infection NN cord-010092-uftc8inx 2855 27 diseases disease NNS cord-010092-uftc8inx 2855 28 , , , cord-010092-uftc8inx 2855 29 but but CC cord-010092-uftc8inx 2855 30 also also RB cord-010092-uftc8inx 2855 31 in in IN cord-010092-uftc8inx 2855 32 transfusion transfusion NN cord-010092-uftc8inx 2855 33 medicine medicine NN cord-010092-uftc8inx 2855 34 . . . cord-010092-uftc8inx 2856 1 An an DT cord-010092-uftc8inx 2856 2 increasing increase VBG cord-010092-uftc8inx 2856 3 probability probability NN cord-010092-uftc8inx 2856 4 of of IN cord-010092-uftc8inx 2856 5 an an DT cord-010092-uftc8inx 2856 6 HLA HLA NNP cord-010092-uftc8inx 2856 7 non non JJ cord-010092-uftc8inx 2856 8 - - JJ cord-010092-uftc8inx 2856 9 compatible compatible JJ cord-010092-uftc8inx 2856 10 blood blood NN cord-010092-uftc8inx 2856 11 products product NNS cord-010092-uftc8inx 2856 12 , , , cord-010092-uftc8inx 2856 13 tissues tissue NNS cord-010092-uftc8inx 2856 14 or or CC cord-010092-uftc8inx 2856 15 organs organ NNS cord-010092-uftc8inx 2856 16 exists exist VBZ cord-010092-uftc8inx 2856 17 due due JJ cord-010092-uftc8inx 2856 18 to to IN cord-010092-uftc8inx 2856 19 the the DT cord-010092-uftc8inx 2856 20 extremely extremely RB cord-010092-uftc8inx 2856 21 high high JJ cord-010092-uftc8inx 2856 22 polymorphism polymorphism NN cord-010092-uftc8inx 2856 23 of of IN cord-010092-uftc8inx 2856 24 HLA HLA NNP cord-010092-uftc8inx 2856 25 genes gene NNS cord-010092-uftc8inx 2856 26 , , , cord-010092-uftc8inx 2856 27 with with IN cord-010092-uftc8inx 2856 28 more more JJR cord-010092-uftc8inx 2856 29 than than IN cord-010092-uftc8inx 2856 30 20,000 20,000 CD cord-010092-uftc8inx 2856 31 described describe VBN cord-010092-uftc8inx 2856 32 alleles allele NNS cord-010092-uftc8inx 2856 33 to to IN cord-010092-uftc8inx 2856 34 date date NN cord-010092-uftc8inx 2856 35 , , , cord-010092-uftc8inx 2856 36 and and CC cord-010092-uftc8inx 2856 37 their -PRON- PRP$ cord-010092-uftc8inx 2856 38 different different JJ cord-010092-uftc8inx 2856 39 frequency frequency NN cord-010092-uftc8inx 2856 40 distribution distribution NN cord-010092-uftc8inx 2856 41 in in IN cord-010092-uftc8inx 2856 42 various various JJ cord-010092-uftc8inx 2856 43 worldwide worldwide JJ cord-010092-uftc8inx 2856 44 populations population NNS cord-010092-uftc8inx 2856 45 . . . cord-010092-uftc8inx 2857 1 The the DT cord-010092-uftc8inx 2857 2 HLA HLA NNP cord-010092-uftc8inx 2857 3 system system NN cord-010092-uftc8inx 2857 4 , , , cord-010092-uftc8inx 2857 5 originally originally RB cord-010092-uftc8inx 2857 6 discovered discover VBN cord-010092-uftc8inx 2857 7 as as IN cord-010092-uftc8inx 2857 8 a a DT cord-010092-uftc8inx 2857 9 result result NN cord-010092-uftc8inx 2857 10 of of IN cord-010092-uftc8inx 2857 11 a a DT cord-010092-uftc8inx 2857 12 transfusion transfusion NN cord-010092-uftc8inx 2857 13 reaction reaction NN cord-010092-uftc8inx 2857 14 in in IN cord-010092-uftc8inx 2857 15 the the DT cord-010092-uftc8inx 2857 16 1950s 1950 NNS cord-010092-uftc8inx 2857 17 , , , cord-010092-uftc8inx 2857 18 can can MD cord-010092-uftc8inx 2857 19 cause cause VB cord-010092-uftc8inx 2857 20 detrimental detrimental JJ cord-010092-uftc8inx 2857 21 immune immune JJ cord-010092-uftc8inx 2857 22 reactions reaction NNS cord-010092-uftc8inx 2857 23 in in IN cord-010092-uftc8inx 2857 24 transfusion transfusion NN cord-010092-uftc8inx 2857 25 therapy therapy NN cord-010092-uftc8inx 2857 26 . . . cord-010092-uftc8inx 2858 1 HLA HLA NNP cord-010092-uftc8inx 2858 2 antibodies antibody NNS cord-010092-uftc8inx 2858 3 present present JJ cord-010092-uftc8inx 2858 4 in in IN cord-010092-uftc8inx 2858 5 the the DT cord-010092-uftc8inx 2858 6 patient patient NN cord-010092-uftc8inx 2858 7 are be VBP cord-010092-uftc8inx 2858 8 responsible responsible JJ cord-010092-uftc8inx 2858 9 for for IN cord-010092-uftc8inx 2858 10 some some DT cord-010092-uftc8inx 2858 11 of of IN cord-010092-uftc8inx 2858 12 these these DT cord-010092-uftc8inx 2858 13 reactions reaction NNS cord-010092-uftc8inx 2858 14 , , , cord-010092-uftc8inx 2858 15 while while IN cord-010092-uftc8inx 2858 16 in in IN cord-010092-uftc8inx 2858 17 other other JJ cord-010092-uftc8inx 2858 18 cases case NNS cord-010092-uftc8inx 2858 19 HLA HLA NNP cord-010092-uftc8inx 2858 20 antibodies antibody NNS cord-010092-uftc8inx 2858 21 or or CC cord-010092-uftc8inx 2858 22 HLA HLA NNP cord-010092-uftc8inx 2858 23 reactive reactive JJ cord-010092-uftc8inx 2858 24 cells cell NNS cord-010092-uftc8inx 2858 25 present present JJ cord-010092-uftc8inx 2858 26 in in IN cord-010092-uftc8inx 2858 27 the the DT cord-010092-uftc8inx 2858 28 transfused transfuse VBN cord-010092-uftc8inx 2858 29 product product NN cord-010092-uftc8inx 2858 30 are be VBP cord-010092-uftc8inx 2858 31 accountable accountable JJ cord-010092-uftc8inx 2858 32 for for IN cord-010092-uftc8inx 2858 33 the the DT cord-010092-uftc8inx 2858 34 immunoreactivity immunoreactivity NN cord-010092-uftc8inx 2858 35 . . . cord-010092-uftc8inx 2859 1 HLA HLA NNP cord-010092-uftc8inx 2859 2 antibodies antibody NNS cord-010092-uftc8inx 2859 3 form form VBP cord-010092-uftc8inx 2859 4 as as IN cord-010092-uftc8inx 2859 5 a a DT cord-010092-uftc8inx 2859 6 result result NN cord-010092-uftc8inx 2859 7 of of IN cord-010092-uftc8inx 2859 8 exposure exposure NN cord-010092-uftc8inx 2859 9 to to IN cord-010092-uftc8inx 2859 10 foreign foreign JJ cord-010092-uftc8inx 2859 11 HLA HLA NNP cord-010092-uftc8inx 2859 12 antigens antigen NNS cord-010092-uftc8inx 2859 13 during during IN cord-010092-uftc8inx 2859 14 pregnancy pregnancy NN cord-010092-uftc8inx 2859 15 , , , cord-010092-uftc8inx 2859 16 transplantations transplantation NNS cord-010092-uftc8inx 2859 17 and and CC cord-010092-uftc8inx 2859 18 blood blood NN cord-010092-uftc8inx 2859 19 transfusions transfusion NNS cord-010092-uftc8inx 2859 20 and and CC cord-010092-uftc8inx 2859 21 can can MD cord-010092-uftc8inx 2859 22 cause cause VB cord-010092-uftc8inx 2859 23 platelet platelet NN cord-010092-uftc8inx 2859 24 immune immune JJ cord-010092-uftc8inx 2859 25 refractoriness refractoriness NN cord-010092-uftc8inx 2859 26 , , , cord-010092-uftc8inx 2859 27 febrile febrile JJ cord-010092-uftc8inx 2859 28 transfusion transfusion NN cord-010092-uftc8inx 2859 29 reaction reaction NN cord-010092-uftc8inx 2859 30 , , , cord-010092-uftc8inx 2859 31 transfusion transfusion NN cord-010092-uftc8inx 2859 32 - - HYPH cord-010092-uftc8inx 2859 33 related relate VBN cord-010092-uftc8inx 2859 34 acute acute JJ cord-010092-uftc8inx 2859 35 lung lung NN cord-010092-uftc8inx 2859 36 injury injury NN cord-010092-uftc8inx 2859 37 , , , cord-010092-uftc8inx 2859 38 and and CC cord-010092-uftc8inx 2859 39 transfusion transfusion NN cord-010092-uftc8inx 2859 40 associated associate VBN cord-010092-uftc8inx 2859 41 graft graft NN cord-010092-uftc8inx 2859 42 versus versus IN cord-010092-uftc8inx 2859 43 host host NN cord-010092-uftc8inx 2859 44 disease disease NN cord-010092-uftc8inx 2859 45 . . . cord-010092-uftc8inx 2860 1 In in IN cord-010092-uftc8inx 2860 2 order order NN cord-010092-uftc8inx 2860 3 to to TO cord-010092-uftc8inx 2860 4 avoid avoid VB cord-010092-uftc8inx 2860 5 or or CC cord-010092-uftc8inx 2860 6 reduce reduce VB cord-010092-uftc8inx 2860 7 the the DT cord-010092-uftc8inx 2860 8 development development NN cord-010092-uftc8inx 2860 9 of of IN cord-010092-uftc8inx 2860 10 these these DT cord-010092-uftc8inx 2860 11 transfusion transfusion NN cord-010092-uftc8inx 2860 12 - - HYPH cord-010092-uftc8inx 2860 13 related relate VBN cord-010092-uftc8inx 2860 14 events event NNS cord-010092-uftc8inx 2860 15 , , , cord-010092-uftc8inx 2860 16 HLA HLA NNP cord-010092-uftc8inx 2860 17 antibody antibody NN cord-010092-uftc8inx 2860 18 negative negative JJ cord-010092-uftc8inx 2860 19 or or CC cord-010092-uftc8inx 2860 20 compatible compatible JJ cord-010092-uftc8inx 2860 21 products product NNS cord-010092-uftc8inx 2860 22 should should MD cord-010092-uftc8inx 2860 23 be be VB cord-010092-uftc8inx 2860 24 used use VBN cord-010092-uftc8inx 2860 25 . . . cord-010092-uftc8inx 2861 1 Almost almost RB cord-010092-uftc8inx 2861 2 all all DT cord-010092-uftc8inx 2861 3 existing exist VBG cord-010092-uftc8inx 2861 4 methods method NNS cord-010092-uftc8inx 2861 5 presently presently RB cord-010092-uftc8inx 2861 6 used use VBN cord-010092-uftc8inx 2861 7 for for IN cord-010092-uftc8inx 2861 8 molecular molecular JJ cord-010092-uftc8inx 2861 9 typing typing NN cord-010092-uftc8inx 2861 10 of of IN cord-010092-uftc8inx 2861 11 HLA HLA NNP cord-010092-uftc8inx 2861 12 polymorphisms polymorphism NNS cord-010092-uftc8inx 2861 13 are be VBP cord-010092-uftc8inx 2861 14 based base VBN cord-010092-uftc8inx 2861 15 on on IN cord-010092-uftc8inx 2861 16 polymerase polymerase NN cord-010092-uftc8inx 2861 17 chain chain NN cord-010092-uftc8inx 2861 18 reaction reaction NN cord-010092-uftc8inx 2861 19 , , , cord-010092-uftc8inx 2861 20 but but CC cord-010092-uftc8inx 2861 21 with with IN cord-010092-uftc8inx 2861 22 different different JJ cord-010092-uftc8inx 2861 23 resolution resolution NN cord-010092-uftc8inx 2861 24 levels level NNS cord-010092-uftc8inx 2861 25 ( ( -LRB- cord-010092-uftc8inx 2861 26 low low JJ cord-010092-uftc8inx 2861 27 resolution resolution NN cord-010092-uftc8inx 2861 28 -two -two : cord-010092-uftc8inx 2861 29 digits digits JJ cord-010092-uftc8inx 2861 30 or or CC cord-010092-uftc8inx 2861 31 high high JJ cord-010092-uftc8inx 2861 32 resolution resolution NN cord-010092-uftc8inx 2861 33 -four -four CC cord-010092-uftc8inx 2861 34 digits digit NNS cord-010092-uftc8inx 2861 35 ) ) -RRB- cord-010092-uftc8inx 2861 36 . . . cord-010092-uftc8inx 2862 1 In in IN cord-010092-uftc8inx 2862 2 addition addition NN cord-010092-uftc8inx 2862 3 to to IN cord-010092-uftc8inx 2862 4 providing provide VBG cord-010092-uftc8inx 2862 5 a a DT cord-010092-uftc8inx 2862 6 more more RBR cord-010092-uftc8inx 2862 7 precise precise JJ cord-010092-uftc8inx 2862 8 detection detection NN cord-010092-uftc8inx 2862 9 of of IN cord-010092-uftc8inx 2862 10 polymorphisms polymorphism NNS cord-010092-uftc8inx 2862 11 at at IN cord-010092-uftc8inx 2862 12 HLA HLA NNP cord-010092-uftc8inx 2862 13 classical classical JJ cord-010092-uftc8inx 2862 14 loci locus NNS cord-010092-uftc8inx 2862 15 ( ( -LRB- cord-010092-uftc8inx 2862 16 e.g. e.g. DT cord-010092-uftc8inx 2862 17 HLA HLA NNP cord-010092-uftc8inx 2862 18 - - HYPH cord-010092-uftc8inx 2862 19 A A NNP cord-010092-uftc8inx 2862 20 , , , cord-010092-uftc8inx 2862 21 -B -b ADD cord-010092-uftc8inx 2862 22 , , , cord-010092-uftc8inx 2862 23 -C -C NNS cord-010092-uftc8inx 2862 24 , , , cord-010092-uftc8inx 2862 25 -DRB1 -DRB1 NNP cord-010092-uftc8inx 2862 26 , , , cord-010092-uftc8inx 2862 27 -DQB1 -DQB1 NNP cord-010092-uftc8inx 2862 28 ) ) -RRB- cord-010092-uftc8inx 2862 29 , , , cord-010092-uftc8inx 2862 30 molecular molecular JJ cord-010092-uftc8inx 2862 31 methods method NNS cord-010092-uftc8inx 2862 32 can can MD cord-010092-uftc8inx 2862 33 also also RB cord-010092-uftc8inx 2862 34 determine determine VB cord-010092-uftc8inx 2862 35 polymorphisms polymorphism NNS cord-010092-uftc8inx 2862 36 at at IN cord-010092-uftc8inx 2862 37 HLA HLA NNP cord-010092-uftc8inx 2862 38 loci locus NNS cord-010092-uftc8inx 2862 39 which which WDT cord-010092-uftc8inx 2862 40 previously previously RB cord-010092-uftc8inx 2862 41 could could MD cord-010092-uftc8inx 2862 42 not not RB cord-010092-uftc8inx 2862 43 be be VB cord-010092-uftc8inx 2862 44 typed type VBN cord-010092-uftc8inx 2862 45 by by IN cord-010092-uftc8inx 2862 46 serology serology NN cord-010092-uftc8inx 2862 47 ( ( -LRB- cord-010092-uftc8inx 2862 48 e.g. e.g. RB cord-010092-uftc8inx 2862 49 HLA HLA NNP cord-010092-uftc8inx 2862 50 - - HYPH cord-010092-uftc8inx 2862 51 DRB3 DRB3 NNP cord-010092-uftc8inx 2862 52 , , , cord-010092-uftc8inx 2862 53 -DRB4 -DRB4 NNP cord-010092-uftc8inx 2862 54 , , , cord-010092-uftc8inx 2862 55 -DRB5 -DRB5 NNP cord-010092-uftc8inx 2862 56 , , , cord-010092-uftc8inx 2862 57 -DQA1 -DQA1 NNP cord-010092-uftc8inx 2862 58 , , , cord-010092-uftc8inx 2862 59 -DPA1 -DPA1 NNP cord-010092-uftc8inx 2862 60 ) ) -RRB- cord-010092-uftc8inx 2862 61 . . . cord-010092-uftc8inx 2863 1 The the DT cord-010092-uftc8inx 2863 2 most most RBS cord-010092-uftc8inx 2863 3 commonly commonly RB cord-010092-uftc8inx 2863 4 used use VBN cord-010092-uftc8inx 2863 5 method method NN cord-010092-uftc8inx 2863 6 for for IN cord-010092-uftc8inx 2863 7 the the DT cord-010092-uftc8inx 2863 8 detection detection NN cord-010092-uftc8inx 2863 9 of of IN cord-010092-uftc8inx 2863 10 HLA HLA NNP cord-010092-uftc8inx 2863 11 antibodies antibody NNS cord-010092-uftc8inx 2863 12 was be VBD cord-010092-uftc8inx 2863 13 until until IN cord-010092-uftc8inx 2863 14 recently recently RB cord-010092-uftc8inx 2863 15 complement complement NN cord-010092-uftc8inx 2863 16 - - HYPH cord-010092-uftc8inx 2863 17 dependent dependent JJ cord-010092-uftc8inx 2863 18 cytotoxicity cytotoxicity NN cord-010092-uftc8inx 2863 19 ( ( -LRB- cord-010092-uftc8inx 2863 20 CDC CDC NNP cord-010092-uftc8inx 2863 21 ) ) -RRB- cord-010092-uftc8inx 2863 22 technique technique NN cord-010092-uftc8inx 2863 23 , , , cord-010092-uftc8inx 2863 24 but but CC cord-010092-uftc8inx 2863 25 it -PRON- PRP cord-010092-uftc8inx 2863 26 is be VBZ cord-010092-uftc8inx 2863 27 increasingly increasingly RB cord-010092-uftc8inx 2863 28 being be VBG cord-010092-uftc8inx 2863 29 replaced replace VBN cord-010092-uftc8inx 2863 30 by by IN cord-010092-uftc8inx 2863 31 a a DT cord-010092-uftc8inx 2863 32 more more RBR cord-010092-uftc8inx 2863 33 sensitive sensitive JJ cord-010092-uftc8inx 2863 34 , , , cord-010092-uftc8inx 2863 35 solid solid JJ cord-010092-uftc8inx 2863 36 phase phase NN cord-010092-uftc8inx 2863 37 based base VBN cord-010092-uftc8inx 2863 38 method method NN cord-010092-uftc8inx 2863 39 ( ( -LRB- cord-010092-uftc8inx 2863 40 Luminex Luminex NNP cord-010092-uftc8inx 2863 41 technology technology NN cord-010092-uftc8inx 2863 42 ) ) -RRB- cord-010092-uftc8inx 2863 43 . . . cord-010092-uftc8inx 2864 1 In in IN cord-010092-uftc8inx 2864 2 conclusion conclusion NN cord-010092-uftc8inx 2864 3 , , , cord-010092-uftc8inx 2864 4 an an DT cord-010092-uftc8inx 2864 5 accurate accurate JJ cord-010092-uftc8inx 2864 6 and and CC cord-010092-uftc8inx 2864 7 precise precise JJ cord-010092-uftc8inx 2864 8 determination determination NN cord-010092-uftc8inx 2864 9 of of IN cord-010092-uftc8inx 2864 10 both both DT cord-010092-uftc8inx 2864 11 HLA HLA NNP cord-010092-uftc8inx 2864 12 gene gene NN cord-010092-uftc8inx 2864 13 polymorphism polymorphism NN cord-010092-uftc8inx 2864 14 and and CC cord-010092-uftc8inx 2864 15 HLA HLA NNP cord-010092-uftc8inx 2864 16 antibodies antibody NNS cord-010092-uftc8inx 2864 17 presence presence NN cord-010092-uftc8inx 2864 18 is be VBZ cord-010092-uftc8inx 2864 19 essential essential JJ cord-010092-uftc8inx 2864 20 for for IN cord-010092-uftc8inx 2864 21 the the DT cord-010092-uftc8inx 2864 22 safe safe JJ cord-010092-uftc8inx 2864 23 and and CC cord-010092-uftc8inx 2864 24 efficient efficient JJ cord-010092-uftc8inx 2864 25 administration administration NN cord-010092-uftc8inx 2864 26 of of IN cord-010092-uftc8inx 2864 27 transfusion transfusion NN cord-010092-uftc8inx 2864 28 products product NNS cord-010092-uftc8inx 2864 29 . . . cord-010092-uftc8inx 2865 1 Background background NN cord-010092-uftc8inx 2865 2 : : : cord-010092-uftc8inx 2866 1 In in IN cord-010092-uftc8inx 2866 2 only only RB cord-010092-uftc8inx 2866 3 a a DT cord-010092-uftc8inx 2866 4 minority minority NN cord-010092-uftc8inx 2866 5 of of IN cord-010092-uftc8inx 2866 6 pregnancies pregnancy NNS cord-010092-uftc8inx 2866 7 complicated complicate VBN cord-010092-uftc8inx 2866 8 with with IN cord-010092-uftc8inx 2866 9 anti anti JJ cord-010092-uftc8inx 2866 10 - - JJ cord-010092-uftc8inx 2866 11 HPA1a hpa1a JJ cord-010092-uftc8inx 2866 12 antibodies antibody NNS cord-010092-uftc8inx 2866 13 serious serious JJ cord-010092-uftc8inx 2866 14 fetal fetal JJ cord-010092-uftc8inx 2866 15 / / SYM cord-010092-uftc8inx 2866 16 neonatal neonatal JJ cord-010092-uftc8inx 2866 17 disease disease NN cord-010092-uftc8inx 2866 18 develops develop VBZ cord-010092-uftc8inx 2866 19 . . . cord-010092-uftc8inx 2867 1 The the DT cord-010092-uftc8inx 2867 2 difficulty difficulty NN cord-010092-uftc8inx 2867 3 in in IN cord-010092-uftc8inx 2867 4 predicting predict VBG cord-010092-uftc8inx 2867 5 which which WDT cord-010092-uftc8inx 2867 6 mothers mother NNS cord-010092-uftc8inx 2867 7 should should MD cord-010092-uftc8inx 2867 8 be be VB cord-010092-uftc8inx 2867 9 treated treat VBN cord-010092-uftc8inx 2867 10 with with IN cord-010092-uftc8inx 2867 11 IVIg ivig JJ cord-010092-uftc8inx 2867 12 hampers hamper NNS cord-010092-uftc8inx 2867 13 implementation implementation NN cord-010092-uftc8inx 2867 14 of of IN cord-010092-uftc8inx 2867 15 FNAIT FNAIT NNS cord-010092-uftc8inx 2867 16 screening screening NN cord-010092-uftc8inx 2867 17 . . . cord-010092-uftc8inx 2868 1 We -PRON- PRP cord-010092-uftc8inx 2868 2 found find VBD cord-010092-uftc8inx 2868 3 that that IN cord-010092-uftc8inx 2868 4 Fc Fc NNP cord-010092-uftc8inx 2868 5 - - HYPH cord-010092-uftc8inx 2868 6 core core NN cord-010092-uftc8inx 2868 7 fucosylation fucosylation NN cord-010092-uftc8inx 2868 8 and and CC cord-010092-uftc8inx 2868 9 galactosylation galactosylation NN cord-010092-uftc8inx 2868 10 are be VBP cord-010092-uftc8inx 2868 11 highly highly RB cord-010092-uftc8inx 2868 12 variable variable JJ cord-010092-uftc8inx 2868 13 in in IN cord-010092-uftc8inx 2868 14 anti anti JJ cord-010092-uftc8inx 2868 15 - - JJ cord-010092-uftc8inx 2868 16 HPA1a hpa1a JJ cord-010092-uftc8inx 2868 17 IgG igg NN cord-010092-uftc8inx 2868 18 , , , cord-010092-uftc8inx 2868 19 and and CC cord-010092-uftc8inx 2868 20 that that IN cord-010092-uftc8inx 2868 21 these these DT cord-010092-uftc8inx 2868 22 glycan glycan NN cord-010092-uftc8inx 2868 23 features feature VBZ cord-010092-uftc8inx 2868 24 strongly strongly RB cord-010092-uftc8inx 2868 25 affect affect VBP cord-010092-uftc8inx 2868 26 binding bind VBG cord-010092-uftc8inx 2868 27 to to IN cord-010092-uftc8inx 2868 28 FccRIIIa FccRIIIa NNP cord-010092-uftc8inx 2868 29 receptor receptor NN cord-010092-uftc8inx 2868 30 . . . cord-010092-uftc8inx 2869 1 The the DT cord-010092-uftc8inx 2869 2 level level NN cord-010092-uftc8inx 2869 3 of of IN cord-010092-uftc8inx 2869 4 Fc Fc NNP cord-010092-uftc8inx 2869 5 - - HYPH cord-010092-uftc8inx 2869 6 core core NN cord-010092-uftc8inx 2869 7 fucosylation fucosylation NN cord-010092-uftc8inx 2869 8 of of IN cord-010092-uftc8inx 2869 9 anti anti JJ cord-010092-uftc8inx 2869 10 - - JJ cord-010092-uftc8inx 2869 11 HPA hpa JJ cord-010092-uftc8inx 2869 12 1a 1a CD cord-010092-uftc8inx 2869 13 alloantibodies alloantibody NNS cord-010092-uftc8inx 2869 14 was be VBD cord-010092-uftc8inx 2869 15 found find VBN cord-010092-uftc8inx 2869 16 to to TO cord-010092-uftc8inx 2869 17 correlate correlate VB cord-010092-uftc8inx 2869 18 with with IN cord-010092-uftc8inx 2869 19 platelet platelet NN cord-010092-uftc8inx 2869 20 count count NN cord-010092-uftc8inx 2869 21 and and CC cord-010092-uftc8inx 2869 22 outcome outcome NN cord-010092-uftc8inx 2869 23 of of IN cord-010092-uftc8inx 2869 24 the the DT cord-010092-uftc8inx 2869 25 newborn newborn NN cord-010092-uftc8inx 2869 26 , , , cord-010092-uftc8inx 2869 27 suggesting suggest VBG cord-010092-uftc8inx 2869 28 that that IN cord-010092-uftc8inx 2869 29 antibodyspecific antibodyspecific NNP cord-010092-uftc8inx 2869 30 fucosylation fucosylation NN cord-010092-uftc8inx 2869 31 might may MD cord-010092-uftc8inx 2869 32 serve serve VB cord-010092-uftc8inx 2869 33 as as IN cord-010092-uftc8inx 2869 34 a a DT cord-010092-uftc8inx 2869 35 biomarker biomarker NN cord-010092-uftc8inx 2869 36 in in IN cord-010092-uftc8inx 2869 37 FNAIT FNAIT NNS cord-010092-uftc8inx 2869 38 screening screening NN cord-010092-uftc8inx 2869 39 . . . cord-010092-uftc8inx 2870 1 However however RB cord-010092-uftc8inx 2870 2 , , , cord-010092-uftc8inx 2870 3 at at IN cord-010092-uftc8inx 2870 4 present present JJ cord-010092-uftc8inx 2870 5 the the DT cord-010092-uftc8inx 2870 6 Fc Fc NNP cord-010092-uftc8inx 2870 7 - - HYPH cord-010092-uftc8inx 2870 8 glycosylation glycosylation NN cord-010092-uftc8inx 2870 9 pattern pattern NN cord-010092-uftc8inx 2870 10 can can MD cord-010092-uftc8inx 2870 11 only only RB cord-010092-uftc8inx 2870 12 be be VB cord-010092-uftc8inx 2870 13 determined determine VBN cord-010092-uftc8inx 2870 14 by by IN cord-010092-uftc8inx 2870 15 complicated complicated JJ cord-010092-uftc8inx 2870 16 methods method NNS cord-010092-uftc8inx 2870 17 involving involve VBG cord-010092-uftc8inx 2870 18 purification purification NN cord-010092-uftc8inx 2870 19 of of IN cord-010092-uftc8inx 2870 20 the the DT cord-010092-uftc8inx 2870 21 antigen antigen NN cord-010092-uftc8inx 2870 22 - - HYPH cord-010092-uftc8inx 2870 23 specific specific JJ cord-010092-uftc8inx 2870 24 IgG igg NN cord-010092-uftc8inx 2870 25 , , , cord-010092-uftc8inx 2870 26 and and CC cord-010092-uftc8inx 2870 27 analyzing analyze VBG cord-010092-uftc8inx 2870 28 trypticly trypticly NNP cord-010092-uftc8inx 2870 29 released release VBD cord-010092-uftc8inx 2870 30 -IgG -IgG : cord-010092-uftc8inx 2870 31 - - HYPH cord-010092-uftc8inx 2870 32 derived derive VBN cord-010092-uftc8inx 2870 33 - - HYPH cord-010092-uftc8inx 2870 34 glycopeptides glycopeptide NNS cord-010092-uftc8inx 2870 35 by by IN cord-010092-uftc8inx 2870 36 tandem tandem JJ cord-010092-uftc8inx 2870 37 liquid liquid JJ cord-010092-uftc8inx 2870 38 chromatography chromatography NN cord-010092-uftc8inx 2870 39 - - HYPH cord-010092-uftc8inx 2870 40 mass mass NN cord-010092-uftc8inx 2870 41 - - HYPH cord-010092-uftc8inx 2870 42 spectrometry spectrometry NN cord-010092-uftc8inx 2870 43 ( ( -LRB- cord-010092-uftc8inx 2870 44 MS MS NNP cord-010092-uftc8inx 2870 45 ) ) -RRB- cord-010092-uftc8inx 2870 46 techniques technique NNS cord-010092-uftc8inx 2870 47 . . . cord-010092-uftc8inx 2871 1 These these DT cord-010092-uftc8inx 2871 2 methods method NNS cord-010092-uftc8inx 2871 3 , , , cord-010092-uftc8inx 2871 4 although although IN cord-010092-uftc8inx 2871 5 powerful powerful JJ cord-010092-uftc8inx 2871 6 , , , cord-010092-uftc8inx 2871 7 are be VBP cord-010092-uftc8inx 2871 8 not not RB cord-010092-uftc8inx 2871 9 yet yet RB cord-010092-uftc8inx 2871 10 suited suit VBN cord-010092-uftc8inx 2871 11 for for IN cord-010092-uftc8inx 2871 12 high high JJ cord-010092-uftc8inx 2871 13 throughput throughput NN cord-010092-uftc8inx 2871 14 clinical clinical JJ cord-010092-uftc8inx 2871 15 screening screening NN cord-010092-uftc8inx 2871 16 . . . cord-010092-uftc8inx 2872 1 Aims aim VBZ cord-010092-uftc8inx 2872 2 : : : cord-010092-uftc8inx 2873 1 Our -PRON- PRP$ cord-010092-uftc8inx 2873 2 aim aim NN cord-010092-uftc8inx 2873 3 was be VBD cord-010092-uftc8inx 2873 4 to to TO cord-010092-uftc8inx 2873 5 provide provide VB cord-010092-uftc8inx 2873 6 a a DT cord-010092-uftc8inx 2873 7 simplified simplified JJ cord-010092-uftc8inx 2873 8 method method NN cord-010092-uftc8inx 2873 9 to to TO cord-010092-uftc8inx 2873 10 quantify quantify VB cord-010092-uftc8inx 2873 11 the the DT cord-010092-uftc8inx 2873 12 biological biological JJ cord-010092-uftc8inx 2873 13 activity activity NN cord-010092-uftc8inx 2873 14 of of IN cord-010092-uftc8inx 2873 15 anti anti JJ cord-010092-uftc8inx 2873 16 - - JJ cord-010092-uftc8inx 2873 17 HPA-1a HPA-1a NNP cord-010092-uftc8inx 2873 18 antibodies antibody NNS cord-010092-uftc8inx 2873 19 , , , cord-010092-uftc8inx 2873 20 and and CC cord-010092-uftc8inx 2873 21 possibly possibly RB cord-010092-uftc8inx 2873 22 other other JJ cord-010092-uftc8inx 2873 23 alloantibodies alloantibody NNS cord-010092-uftc8inx 2873 24 against against IN cord-010092-uftc8inx 2873 25 blood blood NN cord-010092-uftc8inx 2873 26 cells cell NNS cord-010092-uftc8inx 2873 27 . . . cord-010092-uftc8inx 2874 1 Methods method NNS cord-010092-uftc8inx 2874 2 : : : cord-010092-uftc8inx 2874 3 Here here RB cord-010092-uftc8inx 2874 4 we -PRON- PRP cord-010092-uftc8inx 2874 5 explored explore VBD cord-010092-uftc8inx 2874 6 if if IN cord-010092-uftc8inx 2874 7 cellular cellular JJ cord-010092-uftc8inx 2874 8 surface surface NN cord-010092-uftc8inx 2874 9 plasmon plasmon NN cord-010092-uftc8inx 2874 10 resonance resonance NN cord-010092-uftc8inx 2874 11 ( ( -LRB- cord-010092-uftc8inx 2874 12 SPR SPR NNP cord-010092-uftc8inx 2874 13 ) ) -RRB- cord-010092-uftc8inx 2874 14 imaging imaging NN cord-010092-uftc8inx 2874 15 can can MD cord-010092-uftc8inx 2874 16 replace replace VB cord-010092-uftc8inx 2874 17 MS MS NNP cord-010092-uftc8inx 2874 18 , , , cord-010092-uftc8inx 2874 19 resulting result VBG cord-010092-uftc8inx 2874 20 in in IN cord-010092-uftc8inx 2874 21 less less RBR cord-010092-uftc8inx 2874 22 complicated complicated JJ cord-010092-uftc8inx 2874 23 handling handling NN cord-010092-uftc8inx 2874 24 of of IN cord-010092-uftc8inx 2874 25 patient patient NN cord-010092-uftc8inx 2874 26 sera sera NNP cord-010092-uftc8inx 2874 27 and and CC cord-010092-uftc8inx 2874 28 donorantigen donorantigen NN cord-010092-uftc8inx 2874 29 - - HYPH cord-010092-uftc8inx 2874 30 bearing bear VBG cord-010092-uftc8inx 2874 31 cells cell NNS cord-010092-uftc8inx 2874 32 . . . cord-010092-uftc8inx 2875 1 The the DT cord-010092-uftc8inx 2875 2 strength strength NN cord-010092-uftc8inx 2875 3 of of IN cord-010092-uftc8inx 2875 4 the the DT cord-010092-uftc8inx 2875 5 binding binding NN cord-010092-uftc8inx 2875 6 of of IN cord-010092-uftc8inx 2875 7 platelets platelet NNS cord-010092-uftc8inx 2875 8 to to IN cord-010092-uftc8inx 2875 9 FccR FccR NNP cord-010092-uftc8inx 2875 10 on on IN cord-010092-uftc8inx 2875 11 SPR SPR NNP cord-010092-uftc8inx 2875 12 sensor sensor NN cord-010092-uftc8inx 2875 13 was be VBD cord-010092-uftc8inx 2875 14 monitored monitor VBN cord-010092-uftc8inx 2875 15 under under IN cord-010092-uftc8inx 2875 16 flow flow NN cord-010092-uftc8inx 2875 17 . . . cord-010092-uftc8inx 2876 1 The the DT cord-010092-uftc8inx 2876 2 SPR SPR NNP cord-010092-uftc8inx 2876 3 sensor sensor NN cord-010092-uftc8inx 2876 4 was be VBD cord-010092-uftc8inx 2876 5 equipped equip VBN cord-010092-uftc8inx 2876 6 with with IN cord-010092-uftc8inx 2876 7 both both DT cord-010092-uftc8inx 2876 8 WT WT NNP cord-010092-uftc8inx 2876 9 FccRIIIa FccRIIIa NNP cord-010092-uftc8inx 2876 10 ( ( -LRB- cord-010092-uftc8inx 2876 11 sensitive sensitive JJ cord-010092-uftc8inx 2876 12 to to IN cord-010092-uftc8inx 2876 13 Fc Fc NNP cord-010092-uftc8inx 2876 14 - - HYPH cord-010092-uftc8inx 2876 15 glycosylation glycosylation NN cord-010092-uftc8inx 2876 16 status status NN cord-010092-uftc8inx 2876 17 ) ) -RRB- cord-010092-uftc8inx 2876 18 and and CC cord-010092-uftc8inx 2876 19 mutant mutant JJ cord-010092-uftc8inx 2876 20 FccRIIIa FccRIIIa NNP cord-010092-uftc8inx 2876 21 - - HYPH cord-010092-uftc8inx 2876 22 N162A N162A NNP cord-010092-uftc8inx 2876 23 ( ( -LRB- cord-010092-uftc8inx 2876 24 insensitive insensitive JJ cord-010092-uftc8inx 2876 25 to to IN cord-010092-uftc8inx 2876 26 Fcglycosylation Fcglycosylation NNP cord-010092-uftc8inx 2876 27 status status NN cord-010092-uftc8inx 2876 28 ) ) -RRB- cord-010092-uftc8inx 2876 29 . . . cord-010092-uftc8inx 2877 1 In in IN cord-010092-uftc8inx 2877 2 addition addition NN cord-010092-uftc8inx 2877 3 , , , cord-010092-uftc8inx 2877 4 the the DT cord-010092-uftc8inx 2877 5 biosensor biosensor NN cord-010092-uftc8inx 2877 6 was be VBD cord-010092-uftc8inx 2877 7 prepared prepare VBN cord-010092-uftc8inx 2877 8 with with IN cord-010092-uftc8inx 2877 9 anti anti JJ cord-010092-uftc8inx 2877 10 - - JJ cord-010092-uftc8inx 2877 11 platelet platelet JJ cord-010092-uftc8inx 2877 12 CD61 CD61 NNP cord-010092-uftc8inx 2877 13 ( ( -LRB- cord-010092-uftc8inx 2877 14 C17 C17 NNP cord-010092-uftc8inx 2877 15 ) ) -RRB- cord-010092-uftc8inx 2877 16 and and CC cord-010092-uftc8inx 2877 17 anti anti JJ cord-010092-uftc8inx 2877 18 - - JJ cord-010092-uftc8inx 2877 19 IgG igg NN cord-010092-uftc8inx 2877 20 to to TO cord-010092-uftc8inx 2877 21 calibrate calibrate VB cord-010092-uftc8inx 2877 22 the the DT cord-010092-uftc8inx 2877 23 number number NN cord-010092-uftc8inx 2877 24 of of IN cord-010092-uftc8inx 2877 25 injected inject VBN cord-010092-uftc8inx 2877 26 platelet platelet NN cord-010092-uftc8inx 2877 27 as as RB cord-010092-uftc8inx 2877 28 well well RB cord-010092-uftc8inx 2877 29 as as IN cord-010092-uftc8inx 2877 30 to to TO cord-010092-uftc8inx 2877 31 quantify quantify VB cord-010092-uftc8inx 2877 32 IgG igg NN cord-010092-uftc8inx 2877 33 - - HYPH cord-010092-uftc8inx 2877 34 opsonization opsonization NN cord-010092-uftc8inx 2877 35 . . . cord-010092-uftc8inx 2878 1 The the DT cord-010092-uftc8inx 2878 2 quality quality NN cord-010092-uftc8inx 2878 3 of of IN cord-010092-uftc8inx 2878 4 the the DT cord-010092-uftc8inx 2878 5 anti anti JJ cord-010092-uftc8inx 2878 6 - - JJ cord-010092-uftc8inx 2878 7 HPA hpa JJ cord-010092-uftc8inx 2878 8 1a 1a NN cord-010092-uftc8inx 2878 9 glycosylation glycosylation NN cord-010092-uftc8inx 2878 10 was be VBD cord-010092-uftc8inx 2878 11 monitored monitor VBN cord-010092-uftc8inx 2878 12 as as IN cord-010092-uftc8inx 2878 13 the the DT cord-010092-uftc8inx 2878 14 ratio ratio NN cord-010092-uftc8inx 2878 15 of of IN cord-010092-uftc8inx 2878 16 the the DT cord-010092-uftc8inx 2878 17 binding binding NN cord-010092-uftc8inx 2878 18 of of IN cord-010092-uftc8inx 2878 19 opsonized opsonized JJ cord-010092-uftc8inx 2878 20 platelets platelet NNS cord-010092-uftc8inx 2878 21 to to IN cord-010092-uftc8inx 2878 22 the the DT cord-010092-uftc8inx 2878 23 WT WT NNP cord-010092-uftc8inx 2878 24 and and CC cord-010092-uftc8inx 2878 25 the the DT cord-010092-uftc8inx 2878 26 mutant mutant JJ cord-010092-uftc8inx 2878 27 N162A N162A NNP cord-010092-uftc8inx 2878 28 - - HYPH cord-010092-uftc8inx 2878 29 FccRIIIa FccRIIIa NNP cord-010092-uftc8inx 2878 30 . . . cord-010092-uftc8inx 2879 1 Platelets platelet NNS cord-010092-uftc8inx 2879 2 opsonized opsonize VBD cord-010092-uftc8inx 2879 3 with with IN cord-010092-uftc8inx 2879 4 recombinant recombinant JJ cord-010092-uftc8inx 2879 5 glycoengineered glycoengineere VBN cord-010092-uftc8inx 2879 6 anti anti JJ cord-010092-uftc8inx 2879 7 - - JJ cord-010092-uftc8inx 2879 8 platelet platelet JJ cord-010092-uftc8inx 2879 9 antibodies antibody NNS cord-010092-uftc8inx 2879 10 with with IN cord-010092-uftc8inx 2879 11 different different JJ cord-010092-uftc8inx 2879 12 levels level NNS cord-010092-uftc8inx 2879 13 of of IN cord-010092-uftc8inx 2879 14 Fc Fc NNP cord-010092-uftc8inx 2879 15 - - HYPH cord-010092-uftc8inx 2879 16 fucosylation fucosylation NNP cord-010092-uftc8inx 2879 17 were be VBD cord-010092-uftc8inx 2879 18 used use VBN cord-010092-uftc8inx 2879 19 as as IN cord-010092-uftc8inx 2879 20 standards standard NNS cord-010092-uftc8inx 2879 21 . . . cord-010092-uftc8inx 2880 1 For for IN cord-010092-uftc8inx 2880 2 validation validation NN cord-010092-uftc8inx 2880 3 , , , cord-010092-uftc8inx 2880 4 166 166 CD cord-010092-uftc8inx 2880 5 plasma plasma NN cord-010092-uftc8inx 2880 6 samples sample NNS cord-010092-uftc8inx 2880 7 with with IN cord-010092-uftc8inx 2880 8 anti anti JJ cord-010092-uftc8inx 2880 9 - - JJ cord-010092-uftc8inx 2880 10 HPA1a hpa1a JJ cord-010092-uftc8inx 2880 11 antibodies antibody NNS cord-010092-uftc8inx 2880 12 , , , cord-010092-uftc8inx 2880 13 already already RB cord-010092-uftc8inx 2880 14 analyzed analyze VBN cord-010092-uftc8inx 2880 15 by by IN cord-010092-uftc8inx 2880 16 mass mass NN cord-010092-uftc8inx 2880 17 spectrometry spectrometry NN cord-010092-uftc8inx 2880 18 and and CC cord-010092-uftc8inx 2880 19 with with IN cord-010092-uftc8inx 2880 20 known know VBN cord-010092-uftc8inx 2880 21 clinical clinical JJ cord-010092-uftc8inx 2880 22 outcome outcome NN cord-010092-uftc8inx 2880 23 were be VBD cord-010092-uftc8inx 2880 24 tested test VBN cord-010092-uftc8inx 2880 25 ( ( -LRB- cord-010092-uftc8inx 2880 26 Sonneveld Sonneveld NNP cord-010092-uftc8inx 2880 27 , , , cord-010092-uftc8inx 2880 28 BJH BJH NNP cord-010092-uftc8inx 2880 29 , , , cord-010092-uftc8inx 2880 30 2016 2016 CD cord-010092-uftc8inx 2880 31 ) ) -RRB- cord-010092-uftc8inx 2880 32 . . . cord-010092-uftc8inx 2881 1 Results result NNS cord-010092-uftc8inx 2881 2 : : : cord-010092-uftc8inx 2882 1 We -PRON- PRP cord-010092-uftc8inx 2882 2 found find VBD cord-010092-uftc8inx 2882 3 that that IN cord-010092-uftc8inx 2882 4 the the DT cord-010092-uftc8inx 2882 5 ratio ratio NN cord-010092-uftc8inx 2882 6 between between IN cord-010092-uftc8inx 2882 7 the the DT cord-010092-uftc8inx 2882 8 binding binding NN cord-010092-uftc8inx 2882 9 to to IN cord-010092-uftc8inx 2882 10 the the DT cord-010092-uftc8inx 2882 11 WT WT NNP cord-010092-uftc8inx 2882 12 FccRIIIa FccRIIIa NNP cord-010092-uftc8inx 2882 13 and and CC cord-010092-uftc8inx 2882 14 to to IN cord-010092-uftc8inx 2882 15 the the DT cord-010092-uftc8inx 2882 16 mutant mutant JJ cord-010092-uftc8inx 2882 17 N162A N162A NNP cord-010092-uftc8inx 2882 18 - - HYPH cord-010092-uftc8inx 2882 19 FccRIIIa FccRIIIa NNP cord-010092-uftc8inx 2882 20 correlated correlate VBD cord-010092-uftc8inx 2882 21 with with IN cord-010092-uftc8inx 2882 22 the the DT cord-010092-uftc8inx 2882 23 level level NN cord-010092-uftc8inx 2882 24 of of IN cord-010092-uftc8inx 2882 25 fucosylation fucosylation NN cord-010092-uftc8inx 2882 26 of of IN cord-010092-uftc8inx 2882 27 the the DT cord-010092-uftc8inx 2882 28 HPA1a HPA1a NNP cord-010092-uftc8inx 2882 29 antibodies antibody NNS cord-010092-uftc8inx 2882 30 , , , cord-010092-uftc8inx 2882 31 as as IN cord-010092-uftc8inx 2882 32 measured measure VBN cord-010092-uftc8inx 2882 33 by by IN cord-010092-uftc8inx 2882 34 mass mass NN cord-010092-uftc8inx 2882 35 - - HYPH cord-010092-uftc8inx 2882 36 spectrometry spectrometry NN cord-010092-uftc8inx 2882 37 ( ( -LRB- cord-010092-uftc8inx 2882 38 r r NN cord-010092-uftc8inx 2882 39 = = NN cord-010092-uftc8inx 2882 40 À0.524 à0.524 NN cord-010092-uftc8inx 2882 41 ; ; : cord-010092-uftc8inx 2882 42 P p NN cord-010092-uftc8inx 2882 43 < < XX cord-010092-uftc8inx 2882 44 0.0001 0.0001 CD cord-010092-uftc8inx 2882 45 ) ) -RRB- cord-010092-uftc8inx 2882 46 . . . cord-010092-uftc8inx 2883 1 Overall overall RB cord-010092-uftc8inx 2883 2 , , , cord-010092-uftc8inx 2883 3 a a DT cord-010092-uftc8inx 2883 4 similar similar JJ cord-010092-uftc8inx 2883 5 predictive predictive JJ cord-010092-uftc8inx 2883 6 value value NN cord-010092-uftc8inx 2883 7 for for IN cord-010092-uftc8inx 2883 8 disease disease NN cord-010092-uftc8inx 2883 9 severity severity NN cord-010092-uftc8inx 2883 10 was be VBD cord-010092-uftc8inx 2883 11 obtained obtain VBN cord-010092-uftc8inx 2883 12 as as IN cord-010092-uftc8inx 2883 13 we -PRON- PRP cord-010092-uftc8inx 2883 14 previously previously RB cord-010092-uftc8inx 2883 15 reported report VBD cord-010092-uftc8inx 2883 16 for for IN cord-010092-uftc8inx 2883 17 this this DT cord-010092-uftc8inx 2883 18 retrospective retrospective JJ cord-010092-uftc8inx 2883 19 cohort cohort NN cord-010092-uftc8inx 2883 20 . . . cord-010092-uftc8inx 2884 1 In in IN cord-010092-uftc8inx 2884 2 addition addition NN cord-010092-uftc8inx 2884 3 , , , cord-010092-uftc8inx 2884 4 quantitative quantitative JJ cord-010092-uftc8inx 2884 5 information information NN cord-010092-uftc8inx 2884 6 on on IN cord-010092-uftc8inx 2884 7 antibody antibody NN cord-010092-uftc8inx 2884 8 concentration concentration NN cord-010092-uftc8inx 2884 9 can can MD cord-010092-uftc8inx 2884 10 also also RB cord-010092-uftc8inx 2884 11 be be VB cord-010092-uftc8inx 2884 12 extracted extract VBN cord-010092-uftc8inx 2884 13 using use VBG cord-010092-uftc8inx 2884 14 the the DT cord-010092-uftc8inx 2884 15 FccRIIIa FccRIIIa NNP cord-010092-uftc8inx 2884 16 - - HYPH cord-010092-uftc8inx 2884 17 N162A N162A NNP cord-010092-uftc8inx 2884 18 receptor receptor NN cord-010092-uftc8inx 2884 19 as as IN cord-010092-uftc8inx 2884 20 sensor sensor NN cord-010092-uftc8inx 2884 21 on on IN cord-010092-uftc8inx 2884 22 the the DT cord-010092-uftc8inx 2884 23 chip chip NN cord-010092-uftc8inx 2884 24 , , , cord-010092-uftc8inx 2884 25 while while IN cord-010092-uftc8inx 2884 26 anti anti JJ cord-010092-uftc8inx 2884 27 - - NNP cord-010092-uftc8inx 2884 28 IgG IgG NNP cord-010092-uftc8inx 2884 29 gave give VBD cord-010092-uftc8inx 2884 30 aspecific aspecific NNP cord-010092-uftc8inx 2884 31 signals signal NNS cord-010092-uftc8inx 2884 32 , , , cord-010092-uftc8inx 2884 33 presumably presumably RB cord-010092-uftc8inx 2884 34 because because IN cord-010092-uftc8inx 2884 35 it -PRON- PRP cord-010092-uftc8inx 2884 36 recognized recognize VBD cord-010092-uftc8inx 2884 37 cytophilic cytophilic JJ cord-010092-uftc8inx 2884 38 platelet platelet NN cord-010092-uftc8inx 2884 39 - - HYPH cord-010092-uftc8inx 2884 40 FccRIIa fccriia NN cord-010092-uftc8inx 2884 41 - - HYPH cord-010092-uftc8inx 2884 42 bound bind VBN cord-010092-uftc8inx 2884 43 antibodies antibody NNS cord-010092-uftc8inx 2884 44 as as RB cord-010092-uftc8inx 2884 45 well well RB cord-010092-uftc8inx 2884 46 . . . cord-010092-uftc8inx 2885 1 Summary Summary NNP cord-010092-uftc8inx 2885 2 / / SYM cord-010092-uftc8inx 2885 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 2885 4 : : : cord-010092-uftc8inx 2886 1 In in IN cord-010092-uftc8inx 2886 2 conclusion conclusion NN cord-010092-uftc8inx 2886 3 , , , cord-010092-uftc8inx 2886 4 the the DT cord-010092-uftc8inx 2886 5 combined combine VBN cord-010092-uftc8inx 2886 6 use use NN cord-010092-uftc8inx 2886 7 of of IN cord-010092-uftc8inx 2886 8 WT WT NNP cord-010092-uftc8inx 2886 9 and and CC cord-010092-uftc8inx 2886 10 mutant mutant JJ cord-010092-uftc8inx 2886 11 FccRIIIa FccRIIIa NNS cord-010092-uftc8inx 2886 12 in in IN cord-010092-uftc8inx 2886 13 a a DT cord-010092-uftc8inx 2886 14 label label NN cord-010092-uftc8inx 2886 15 free free JJ cord-010092-uftc8inx 2886 16 SPR SPR NNP cord-010092-uftc8inx 2886 17 assay assay NN cord-010092-uftc8inx 2886 18 provides provide VBZ cord-010092-uftc8inx 2886 19 both both DT cord-010092-uftc8inx 2886 20 quantitative quantitative JJ cord-010092-uftc8inx 2886 21 and and CC cord-010092-uftc8inx 2886 22 qualitative qualitative JJ cord-010092-uftc8inx 2886 23 information information NN cord-010092-uftc8inx 2886 24 of of IN cord-010092-uftc8inx 2886 25 platelet platelet NN cord-010092-uftc8inx 2886 26 bound bind VBN cord-010092-uftc8inx 2886 27 anti anti JJ cord-010092-uftc8inx 2886 28 - - JJ cord-010092-uftc8inx 2886 29 HPA hpa JJ cord-010092-uftc8inx 2886 30 1a 1a CD cord-010092-uftc8inx 2886 31 antibodies antibody NNS cord-010092-uftc8inx 2886 32 , , , cord-010092-uftc8inx 2886 33 which which WDT cord-010092-uftc8inx 2886 34 circumvents circumvent VBZ cord-010092-uftc8inx 2886 35 the the DT cord-010092-uftc8inx 2886 36 need need NN cord-010092-uftc8inx 2886 37 for for IN cord-010092-uftc8inx 2886 38 purification purification NN cord-010092-uftc8inx 2886 39 of of IN cord-010092-uftc8inx 2886 40 specific specific JJ cord-010092-uftc8inx 2886 41 antibodies antibody NNS cord-010092-uftc8inx 2886 42 and and CC cord-010092-uftc8inx 2886 43 laborious laborious JJ cord-010092-uftc8inx 2886 44 mass mass NNP cord-010092-uftc8inx 2886 45 spectrometric spectrometric NN cord-010092-uftc8inx 2886 46 analysis analysis NN cord-010092-uftc8inx 2886 47 . . . cord-010092-uftc8inx 2887 1 This this DT cord-010092-uftc8inx 2887 2 approach approach NN cord-010092-uftc8inx 2887 3 might may MD cord-010092-uftc8inx 2887 4 be be VB cord-010092-uftc8inx 2887 5 generally generally RB cord-010092-uftc8inx 2887 6 applicable applicable JJ cord-010092-uftc8inx 2887 7 to to TO cord-010092-uftc8inx 2887 8 determine determine VB cord-010092-uftc8inx 2887 9 the the DT cord-010092-uftc8inx 2887 10 biological biological JJ cord-010092-uftc8inx 2887 11 activity activity NN cord-010092-uftc8inx 2887 12 of of IN cord-010092-uftc8inx 2887 13 cell cell NN cord-010092-uftc8inx 2887 14 bound bind VBN cord-010092-uftc8inx 2887 15 antibodies antibody NNS cord-010092-uftc8inx 2887 16 not not RB cord-010092-uftc8inx 2887 17 only only RB cord-010092-uftc8inx 2887 18 for for IN cord-010092-uftc8inx 2887 19 anti anti JJ cord-010092-uftc8inx 2887 20 - - JJ cord-010092-uftc8inx 2887 21 HPA1a hpa1a JJ cord-010092-uftc8inx 2887 22 in in IN cord-010092-uftc8inx 2887 23 FNAIT FNAIT NNS cord-010092-uftc8inx 2887 24 , , , cord-010092-uftc8inx 2887 25 but but CC cord-010092-uftc8inx 2887 26 also also RB cord-010092-uftc8inx 2887 27 for for IN cord-010092-uftc8inx 2887 28 anti anti JJ cord-010092-uftc8inx 2887 29 - - JJ cord-010092-uftc8inx 2887 30 RhD rhd JJ cord-010092-uftc8inx 2887 31 alloantibodies alloantibody NNS cord-010092-uftc8inx 2887 32 in in IN cord-010092-uftc8inx 2887 33 HDFN HDFN NNP cord-010092-uftc8inx 2887 34 or or CC cord-010092-uftc8inx 2887 35 anti anti JJ cord-010092-uftc8inx 2887 36 - - JJ cord-010092-uftc8inx 2887 37 platelet platelet JJ cord-010092-uftc8inx 2887 38 antibodies antibody NNS cord-010092-uftc8inx 2887 39 in in IN cord-010092-uftc8inx 2887 40 ITP ITP NNP cord-010092-uftc8inx 2887 41 . . . cord-010092-uftc8inx 2888 1 Background background NN cord-010092-uftc8inx 2888 2 : : : cord-010092-uftc8inx 2889 1 Immunization immunization NN cord-010092-uftc8inx 2889 2 against against IN cord-010092-uftc8inx 2889 3 the the DT cord-010092-uftc8inx 2889 4 human human JJ cord-010092-uftc8inx 2889 5 platelet platelet NN cord-010092-uftc8inx 2889 6 HPA-1a HPA-1a NNP cord-010092-uftc8inx 2889 7 alloantigen alloantigen NNP cord-010092-uftc8inx 2889 8 is be VBZ cord-010092-uftc8inx 2889 9 the the DT cord-010092-uftc8inx 2889 10 most most RBS cord-010092-uftc8inx 2889 11 common common JJ cord-010092-uftc8inx 2889 12 cause cause NN cord-010092-uftc8inx 2889 13 of of IN cord-010092-uftc8inx 2889 14 severe severe JJ cord-010092-uftc8inx 2889 15 fetal fetal JJ cord-010092-uftc8inx 2889 16 and and CC cord-010092-uftc8inx 2889 17 neonatal neonatal JJ cord-010092-uftc8inx 2889 18 alloimmune alloimmune JJ cord-010092-uftc8inx 2889 19 thrombocytopenia thrombocytopenia NN cord-010092-uftc8inx 2889 20 ( ( -LRB- cord-010092-uftc8inx 2889 21 FNAIT FNAIT NNP cord-010092-uftc8inx 2889 22 ) ) -RRB- cord-010092-uftc8inx 2889 23 in in IN cord-010092-uftc8inx 2889 24 otherwise otherwise RB cord-010092-uftc8inx 2889 25 healthy healthy JJ cord-010092-uftc8inx 2889 26 term term NN cord-010092-uftc8inx 2889 27 newborns newborn NNS cord-010092-uftc8inx 2889 28 . . . cord-010092-uftc8inx 2890 1 The the DT cord-010092-uftc8inx 2890 2 screening screening NN cord-010092-uftc8inx 2890 3 for for IN cord-010092-uftc8inx 2890 4 HPA-1a HPA-1a NNP cord-010092-uftc8inx 2890 5 antigen antigen NN cord-010092-uftc8inx 2890 6 in in IN cord-010092-uftc8inx 2890 7 pregnant pregnant JJ cord-010092-uftc8inx 2890 8 women woman NNS cord-010092-uftc8inx 2890 9 is be VBZ cord-010092-uftc8inx 2890 10 an an DT cord-010092-uftc8inx 2890 11 important important JJ cord-010092-uftc8inx 2890 12 tool tool NN cord-010092-uftc8inx 2890 13 for for IN cord-010092-uftc8inx 2890 14 identification identification NN cord-010092-uftc8inx 2890 15 of of IN cord-010092-uftc8inx 2890 16 pregnant pregnant JJ cord-010092-uftc8inx 2890 17 women woman NNS cord-010092-uftc8inx 2890 18 at at IN cord-010092-uftc8inx 2890 19 risk risk NN cord-010092-uftc8inx 2890 20 of of IN cord-010092-uftc8inx 2890 21 having have VBG cord-010092-uftc8inx 2890 22 a a DT cord-010092-uftc8inx 2890 23 fetus fetus NN cord-010092-uftc8inx 2890 24 / / SYM cord-010092-uftc8inx 2890 25 neonate neonate NN cord-010092-uftc8inx 2890 26 with with IN cord-010092-uftc8inx 2890 27 FNAIT FNAIT NNP cord-010092-uftc8inx 2890 28 . . . cord-010092-uftc8inx 2891 1 Any any DT cord-010092-uftc8inx 2891 2 targeted target VBN cord-010092-uftc8inx 2891 3 intervention intervention NN cord-010092-uftc8inx 2891 4 depends depend VBZ cord-010092-uftc8inx 2891 5 on on IN cord-010092-uftc8inx 2891 6 efficient efficient JJ cord-010092-uftc8inx 2891 7 screening screening NN cord-010092-uftc8inx 2891 8 methods method NNS cord-010092-uftc8inx 2891 9 as as RB cord-010092-uftc8inx 2891 10 well well RB cord-010092-uftc8inx 2891 11 as as IN cord-010092-uftc8inx 2891 12 sensitive sensitive JJ cord-010092-uftc8inx 2891 13 and and CC cord-010092-uftc8inx 2891 14 specific specific JJ cord-010092-uftc8inx 2891 15 methods method NNS cord-010092-uftc8inx 2891 16 for for IN cord-010092-uftc8inx 2891 17 detection detection NN cord-010092-uftc8inx 2891 18 of of IN cord-010092-uftc8inx 2891 19 anti anti JJ cord-010092-uftc8inx 2891 20 - - NNP cord-010092-uftc8inx 2891 21 HPA-1a HPA-1a NNP cord-010092-uftc8inx 2891 22 . . . cord-010092-uftc8inx 2892 1 Within within IN cord-010092-uftc8inx 2892 2 the the DT cord-010092-uftc8inx 2892 3 framework framework NN cord-010092-uftc8inx 2892 4 of of IN cord-010092-uftc8inx 2892 5 the the DT cord-010092-uftc8inx 2892 6 Polish polish JJ cord-010092-uftc8inx 2892 7 - - HYPH cord-010092-uftc8inx 2892 8 Norwegian norwegian JJ cord-010092-uftc8inx 2892 9 project project NN cord-010092-uftc8inx 2892 10 ( ( -LRB- cord-010092-uftc8inx 2892 11 PREVFNAIT PREVFNAIT NNP cord-010092-uftc8inx 2892 12 ) ) -RRB- cord-010092-uftc8inx 2892 13 we -PRON- PRP cord-010092-uftc8inx 2892 14 have have VBP cord-010092-uftc8inx 2892 15 performed perform VBN cord-010092-uftc8inx 2892 16 HPA-1a HPA-1a NNP cord-010092-uftc8inx 2892 17 screening screening NN cord-010092-uftc8inx 2892 18 program program NN cord-010092-uftc8inx 2892 19 in in IN cord-010092-uftc8inx 2892 20 Poland Poland NNP cord-010092-uftc8inx 2892 21 . . . cord-010092-uftc8inx 2893 1 Aims aim VBZ cord-010092-uftc8inx 2893 2 : : : cord-010092-uftc8inx 2894 1 Our -PRON- PRP$ cord-010092-uftc8inx 2894 2 aim aim NN cord-010092-uftc8inx 2894 3 was be VBD cord-010092-uftc8inx 2894 4 to to TO cord-010092-uftc8inx 2894 5 assess assess VB cord-010092-uftc8inx 2894 6 the the DT cord-010092-uftc8inx 2894 7 frequency frequency NN cord-010092-uftc8inx 2894 8 anti anti NNP cord-010092-uftc8inx 2894 9 - - NNP cord-010092-uftc8inx 2894 10 HPA-1a HPA-1a NNP cord-010092-uftc8inx 2894 11 antibody antibody NN cord-010092-uftc8inx 2894 12 detection detection NN cord-010092-uftc8inx 2894 13 and and CC cord-010092-uftc8inx 2894 14 the the DT cord-010092-uftc8inx 2894 15 clinical clinical JJ cord-010092-uftc8inx 2894 16 outcome outcome NN cord-010092-uftc8inx 2894 17 of of IN cord-010092-uftc8inx 2894 18 newborns newborn NNS cord-010092-uftc8inx 2894 19 identified identify VBN cord-010092-uftc8inx 2894 20 through through IN cord-010092-uftc8inx 2894 21 the the DT cord-010092-uftc8inx 2894 22 study study NN cord-010092-uftc8inx 2894 23 . . . cord-010092-uftc8inx 2895 1 Women woman NNS cord-010092-uftc8inx 2895 2 who who WP cord-010092-uftc8inx 2895 3 joined join VBD cord-010092-uftc8inx 2895 4 the the DT cord-010092-uftc8inx 2895 5 program program NN cord-010092-uftc8inx 2895 6 due due IN cord-010092-uftc8inx 2895 7 to to IN cord-010092-uftc8inx 2895 8 the the DT cord-010092-uftc8inx 2895 9 FNAIT FNAIT NNS cord-010092-uftc8inx 2895 10 in in IN cord-010092-uftc8inx 2895 11 the the DT cord-010092-uftc8inx 2895 12 previous previous JJ cord-010092-uftc8inx 2895 13 child child NN cord-010092-uftc8inx 2895 14 or or CC cord-010092-uftc8inx 2895 15 in in IN cord-010092-uftc8inx 2895 16 the the DT cord-010092-uftc8inx 2895 17 current current JJ cord-010092-uftc8inx 2895 18 newborn newborn NN cord-010092-uftc8inx 2895 19 are be VBP cord-010092-uftc8inx 2895 20 not not RB cord-010092-uftc8inx 2895 21 analyzed analyze VBN cord-010092-uftc8inx 2895 22 in in IN cord-010092-uftc8inx 2895 23 this this DT cord-010092-uftc8inx 2895 24 study study NN cord-010092-uftc8inx 2895 25 . . . cord-010092-uftc8inx 2896 1 Methods method NNS cord-010092-uftc8inx 2896 2 : : : cord-010092-uftc8inx 2896 3 HPA-1a HPA-1a NNP cord-010092-uftc8inx 2896 4 screening screening NN cord-010092-uftc8inx 2896 5 of of IN cord-010092-uftc8inx 2896 6 24 24 CD cord-010092-uftc8inx 2896 7 244 244 CD cord-010092-uftc8inx 2896 8 pregnant pregnant JJ cord-010092-uftc8inx 2896 9 women woman NNS cord-010092-uftc8inx 2896 10 in in IN cord-010092-uftc8inx 2896 11 8 8 CD cord-010092-uftc8inx 2896 12 - - SYM cord-010092-uftc8inx 2896 13 40 40 CD cord-010092-uftc8inx 2896 14 gestational gestational JJ cord-010092-uftc8inx 2896 15 weeks week NNS cord-010092-uftc8inx 2896 16 was be VBD cord-010092-uftc8inx 2896 17 performed perform VBN cord-010092-uftc8inx 2896 18 by by IN cord-010092-uftc8inx 2896 19 FACS FACS NNP cord-010092-uftc8inx 2896 20 phenotyping phenotyping NN cord-010092-uftc8inx 2896 21 or or CC cord-010092-uftc8inx 2896 22 RQ rq NN cord-010092-uftc8inx 2896 23 - - HYPH cord-010092-uftc8inx 2896 24 PCR pcr NN cord-010092-uftc8inx 2896 25 genotyping genotyping NN cord-010092-uftc8inx 2896 26 at at IN cord-010092-uftc8inx 2896 27 IHTM IHTM NNP cord-010092-uftc8inx 2896 28 in in IN cord-010092-uftc8inx 2896 29 Warsaw Warsaw NNP cord-010092-uftc8inx 2896 30 . . . cord-010092-uftc8inx 2897 1 HPA-1a HPA-1a NNP cord-010092-uftc8inx 2897 2 negative negative JJ cord-010092-uftc8inx 2897 3 / / SYM cord-010092-uftc8inx 2897 4 HPA-1B/1B hpa-1b/1b CD cord-010092-uftc8inx 2897 5 women woman NNS cord-010092-uftc8inx 2897 6 were be VBD cord-010092-uftc8inx 2897 7 tested test VBN cord-010092-uftc8inx 2897 8 for for IN cord-010092-uftc8inx 2897 9 HLA HLA NNP cord-010092-uftc8inx 2897 10 DRB3 DRB3 NNP cord-010092-uftc8inx 2897 11 * * NFP cord-010092-uftc8inx 2897 12 01:01 01:01 CD cord-010092-uftc8inx 2897 13 and and CC cord-010092-uftc8inx 2897 14 for for IN cord-010092-uftc8inx 2897 15 anti anti NNP cord-010092-uftc8inx 2897 16 - - JJ cord-010092-uftc8inx 2897 17 HPA-1a HPA-1a NNP cord-010092-uftc8inx 2897 18 antibodies antibody NNS cord-010092-uftc8inx 2897 19 by by IN cord-010092-uftc8inx 2897 20 MAIPA MAIPA NNP cord-010092-uftc8inx 2897 21 ( ( -LRB- cord-010092-uftc8inx 2897 22 followed follow VBN cord-010092-uftc8inx 2897 23 up up RP cord-010092-uftc8inx 2897 24 at at IN cord-010092-uftc8inx 2897 25 week week NN cord-010092-uftc8inx 2897 26 17 17 CD cord-010092-uftc8inx 2897 27 - - SYM cord-010092-uftc8inx 2897 28 20 20 CD cord-010092-uftc8inx 2897 29 , , , cord-010092-uftc8inx 2897 30 28 28 CD cord-010092-uftc8inx 2897 31 , , , cord-010092-uftc8inx 2897 32 32 32 CD cord-010092-uftc8inx 2897 33 , , , cord-010092-uftc8inx 2897 34 38 38 CD cord-010092-uftc8inx 2897 35 - - SYM cord-010092-uftc8inx 2897 36 40 40 CD cord-010092-uftc8inx 2897 37 and and CC cord-010092-uftc8inx 2897 38 6 6 CD cord-010092-uftc8inx 2897 39 weeks week NNS cord-010092-uftc8inx 2897 40 after after IN cord-010092-uftc8inx 2897 41 delivery delivery NN cord-010092-uftc8inx 2897 42 ) ) -RRB- cord-010092-uftc8inx 2897 43 . . . cord-010092-uftc8inx 2898 1 If if IN cord-010092-uftc8inx 2898 2 anti anti JJ cord-010092-uftc8inx 2898 3 - - JJ cord-010092-uftc8inx 2898 4 HPA-1a HPA-1a NNP cord-010092-uftc8inx 2898 5 were be VBD cord-010092-uftc8inx 2898 6 detected detect VBN cord-010092-uftc8inx 2898 7 , , , cord-010092-uftc8inx 2898 8 quantitative quantitative JJ cord-010092-uftc8inx 2898 9 MAIPA MAIPA NNP cord-010092-uftc8inx 2898 10 was be VBD cord-010092-uftc8inx 2898 11 performed perform VBN cord-010092-uftc8inx 2898 12 . . . cord-010092-uftc8inx 2899 1 All all DT cord-010092-uftc8inx 2899 2 HPA-1a HPA-1a NNP cord-010092-uftc8inx 2899 3 negative negative JJ cord-010092-uftc8inx 2899 4 women woman NNS cord-010092-uftc8inx 2899 5 were be VBD cord-010092-uftc8inx 2899 6 contacted contact VBN cord-010092-uftc8inx 2899 7 for for IN cord-010092-uftc8inx 2899 8 information information NN cord-010092-uftc8inx 2899 9 concerning concern VBG cord-010092-uftc8inx 2899 10 the the DT cord-010092-uftc8inx 2899 11 newborn newborn NN cord-010092-uftc8inx 2899 12 . . . cord-010092-uftc8inx 2900 1 If if IN cord-010092-uftc8inx 2900 2 the the DT cord-010092-uftc8inx 2900 3 baby baby NN cord-010092-uftc8inx 2900 4 had have VBD cord-010092-uftc8inx 2900 5 thrombocytopenia thrombocytopenia VBN cord-010092-uftc8inx 2900 6 and and CC cord-010092-uftc8inx 2900 7 anti anti NNP cord-010092-uftc8inx 2900 8 - - NNP cord-010092-uftc8inx 2900 9 HPA-1a HPA-1a NNP cord-010092-uftc8inx 2900 10 were be VBD cord-010092-uftc8inx 2900 11 not not RB cord-010092-uftc8inx 2900 12 detected detect VBN cord-010092-uftc8inx 2900 13 by by IN cord-010092-uftc8inx 2900 14 MAIPA MAIPA NNP cord-010092-uftc8inx 2900 15 , , , cord-010092-uftc8inx 2900 16 the the DT cord-010092-uftc8inx 2900 17 look look NN cord-010092-uftc8inx 2900 18 back back RB cord-010092-uftc8inx 2900 19 samples sample NNS cord-010092-uftc8inx 2900 20 were be VBD cord-010092-uftc8inx 2900 21 tested test VBN cord-010092-uftc8inx 2900 22 retrospectively retrospectively RB cord-010092-uftc8inx 2900 23 by by IN cord-010092-uftc8inx 2900 24 PAKLx PAKLx NNP cord-010092-uftc8inx 2900 25 test test NN cord-010092-uftc8inx 2900 26 ( ( -LRB- cord-010092-uftc8inx 2900 27 Immucor Immucor NNP cord-010092-uftc8inx 2900 28 ) ) -RRB- cord-010092-uftc8inx 2900 29 . . . cord-010092-uftc8inx 2901 1 Results result NNS cord-010092-uftc8inx 2901 2 : : : cord-010092-uftc8inx 2902 1 554 554 CD cord-010092-uftc8inx 2902 2 HPA-1a HPA-1a NNP cord-010092-uftc8inx 2902 3 negative negative JJ cord-010092-uftc8inx 2902 4 women woman NNS cord-010092-uftc8inx 2902 5 were be VBD cord-010092-uftc8inx 2902 6 identified identify VBN cord-010092-uftc8inx 2902 7 ( ( -LRB- cord-010092-uftc8inx 2902 8 2.3 2.3 CD cord-010092-uftc8inx 2902 9 % % NN cord-010092-uftc8inx 2902 10 ) ) -RRB- cord-010092-uftc8inx 2902 11 . . . cord-010092-uftc8inx 2903 1 Anti Anti NNP cord-010092-uftc8inx 2903 2 - - NNP cord-010092-uftc8inx 2903 3 HPA-1a HPA-1a NNP cord-010092-uftc8inx 2903 4 was be VBD cord-010092-uftc8inx 2903 5 antibodies antibody NNS cord-010092-uftc8inx 2903 6 were be VBD cord-010092-uftc8inx 2903 7 detected detect VBN cord-010092-uftc8inx 2903 8 by by IN cord-010092-uftc8inx 2903 9 MAIPA MAIPA NNP cord-010092-uftc8inx 2903 10 in in IN cord-010092-uftc8inx 2903 11 44 44 CD cord-010092-uftc8inx 2903 12 women woman NNS cord-010092-uftc8inx 2903 13 ( ( -LRB- cord-010092-uftc8inx 2903 14 two two CD cord-010092-uftc8inx 2903 15 delivered deliver VBN cord-010092-uftc8inx 2903 16 tweens tween NNS cord-010092-uftc8inx 2903 17 ) ) -RRB- cord-010092-uftc8inx 2903 18 . . . cord-010092-uftc8inx 2904 1 In in IN cord-010092-uftc8inx 2904 2 addition addition NN cord-010092-uftc8inx 2904 3 , , , cord-010092-uftc8inx 2904 4 anti anti NNP cord-010092-uftc8inx 2904 5 - - NNP cord-010092-uftc8inx 2904 6 HPA-1a HPA-1a NNP cord-010092-uftc8inx 2904 7 antibodies antibody NNS cord-010092-uftc8inx 2904 8 were be VBD cord-010092-uftc8inx 2904 9 later later RB cord-010092-uftc8inx 2904 10 detected detect VBN cord-010092-uftc8inx 2904 11 by by IN cord-010092-uftc8inx 2904 12 PAKLx PAKLx NNS cord-010092-uftc8inx 2904 13 in in IN cord-010092-uftc8inx 2904 14 further further JJ cord-010092-uftc8inx 2904 15 3 3 CD cord-010092-uftc8inx 2904 16 women woman NNS cord-010092-uftc8inx 2904 17 who who WP cord-010092-uftc8inx 2904 18 delivered deliver VBD cord-010092-uftc8inx 2904 19 baby baby NN cord-010092-uftc8inx 2904 20 with with IN cord-010092-uftc8inx 2904 21 severe severe JJ cord-010092-uftc8inx 2904 22 thrombocytopenia thrombocytopenia NN cord-010092-uftc8inx 2904 23 and/or and/or CC cord-010092-uftc8inx 2904 24 ICH ICH NNP cord-010092-uftc8inx 2904 25 . . . cord-010092-uftc8inx 2905 1 Total total JJ cord-010092-uftc8inx 2905 2 number number NN cord-010092-uftc8inx 2905 3 of of IN cord-010092-uftc8inx 2905 4 immunized immunize VBN cord-010092-uftc8inx 2905 5 mothers mother NNS cord-010092-uftc8inx 2905 6 was be VBD cord-010092-uftc8inx 2905 7 47 47 CD cord-010092-uftc8inx 2905 8 ( ( -LRB- cord-010092-uftc8inx 2905 9 8.5 8.5 CD cord-010092-uftc8inx 2905 10 % % NN cord-010092-uftc8inx 2905 11 ) ) -RRB- cord-010092-uftc8inx 2905 12 . . . cord-010092-uftc8inx 2906 1 They -PRON- PRP cord-010092-uftc8inx 2906 2 delivered deliver VBD cord-010092-uftc8inx 2906 3 49 49 CD cord-010092-uftc8inx 2906 4 babies baby NNS cord-010092-uftc8inx 2906 5 ; ; : cord-010092-uftc8inx 2906 6 35 35 CD cord-010092-uftc8inx 2906 7 were be VBD cord-010092-uftc8inx 2906 8 boys boy NNS cord-010092-uftc8inx 2906 9 . . . cord-010092-uftc8inx 2907 1 Three three CD cord-010092-uftc8inx 2907 2 women woman NNS cord-010092-uftc8inx 2907 3 were be VBD cord-010092-uftc8inx 2907 4 treated treat VBN cord-010092-uftc8inx 2907 5 by by IN cord-010092-uftc8inx 2907 6 IVIg IVIg NNP cord-010092-uftc8inx 2907 7 : : : cord-010092-uftc8inx 2907 8 two two CD cord-010092-uftc8inx 2907 9 by by IN cord-010092-uftc8inx 2907 10 4 4 CD cord-010092-uftc8inx 2907 11 and and CC cord-010092-uftc8inx 2907 12 8 8 CD cord-010092-uftc8inx 2907 13 injections injection NNS cord-010092-uftc8inx 2907 14 since since IN cord-010092-uftc8inx 2907 15 33 33 CD cord-010092-uftc8inx 2907 16 th th XX cord-010092-uftc8inx 2907 17 and and CC cord-010092-uftc8inx 2907 18 26 26 CD cord-010092-uftc8inx 2907 19 th th XX cord-010092-uftc8inx 2907 20 gw gw NNP cord-010092-uftc8inx 2907 21 respectively respectively RB cord-010092-uftc8inx 2907 22 . . . cord-010092-uftc8inx 2908 1 The the DT cord-010092-uftc8inx 2908 2 anti anti JJ cord-010092-uftc8inx 2908 3 - - JJ cord-010092-uftc8inx 2908 4 HPA-1a HPA-1a NNP cord-010092-uftc8inx 2908 5 concentration concentration NN cord-010092-uftc8inx 2908 6 in in IN cord-010092-uftc8inx 2908 7 the the DT cord-010092-uftc8inx 2908 8 1 1 CD cord-010092-uftc8inx 2908 9 st st NNP cord-010092-uftc8inx 2908 10 one one CD cord-010092-uftc8inx 2908 11 was be VBD cord-010092-uftc8inx 2908 12 0.4 0.4 CD cord-010092-uftc8inx 2908 13 ; ; : cord-010092-uftc8inx 2908 14 0.1 0.1 CD cord-010092-uftc8inx 2908 15 ; ; : cord-010092-uftc8inx 2909 1 5.88 5.88 CD cord-010092-uftc8inx 2909 2 IU IU NNP cord-010092-uftc8inx 2909 3 / / , cord-010092-uftc8inx 2909 4 ml ml NN cord-010092-uftc8inx 2909 5 in in IN cord-010092-uftc8inx 2909 6 17 17 CD cord-010092-uftc8inx 2909 7 , , , cord-010092-uftc8inx 2909 8 28 28 CD cord-010092-uftc8inx 2909 9 , , , cord-010092-uftc8inx 2909 10 32 32 CD cord-010092-uftc8inx 2909 11 gw gw NNS cord-010092-uftc8inx 2909 12 respectively respectively RB cord-010092-uftc8inx 2909 13 and and CC cord-010092-uftc8inx 2909 14 in in IN cord-010092-uftc8inx 2909 15 the the DT cord-010092-uftc8inx 2909 16 2 2 CD cord-010092-uftc8inx 2909 17 nd nd NNP cord-010092-uftc8inx 2909 18 < < XX cord-010092-uftc8inx 2909 19 0.05 0.05 CD cord-010092-uftc8inx 2909 20 IU IU NNP cord-010092-uftc8inx 2909 21 / / , cord-010092-uftc8inx 2909 22 ml ml XX cord-010092-uftc8inx 2909 23 in in IN cord-010092-uftc8inx 2909 24 all all DT cord-010092-uftc8inx 2909 25 examined examine VBN cord-010092-uftc8inx 2909 26 samples sample NNS cord-010092-uftc8inx 2909 27 . . . cord-010092-uftc8inx 2910 1 The the DT cord-010092-uftc8inx 2910 2 decision decision NN cord-010092-uftc8inx 2910 3 on on IN cord-010092-uftc8inx 2910 4 treatment treatment NN cord-010092-uftc8inx 2910 5 was be VBD cord-010092-uftc8inx 2910 6 based base VBN cord-010092-uftc8inx 2910 7 on on IN cord-010092-uftc8inx 2910 8 the the DT cord-010092-uftc8inx 2910 9 low low JJ cord-010092-uftc8inx 2910 10 PLT PLT NNP cord-010092-uftc8inx 2910 11 count~50 count~50 NNP cord-010092-uftc8inx 2910 12 G G NNP cord-010092-uftc8inx 2910 13 / / SYM cord-010092-uftc8inx 2910 14 L l NN cord-010092-uftc8inx 2910 15 in in IN cord-010092-uftc8inx 2910 16 the the DT cord-010092-uftc8inx 2910 17 fetus fetus NN cord-010092-uftc8inx 2910 18 in in IN cord-010092-uftc8inx 2910 19 cordocentesis cordocentesis NN cord-010092-uftc8inx 2910 20 . . . cord-010092-uftc8inx 2911 1 Their -PRON- PRP$ cord-010092-uftc8inx 2911 2 newborns newborn NNS cord-010092-uftc8inx 2911 3 ( ( -LRB- cord-010092-uftc8inx 2911 4 one one CD cord-010092-uftc8inx 2911 5 delivered deliver VBN cord-010092-uftc8inx 2911 6 tweens tween NNS cord-010092-uftc8inx 2911 7 ) ) -RRB- cord-010092-uftc8inx 2911 8 were be VBD cord-010092-uftc8inx 2911 9 healthy healthy JJ cord-010092-uftc8inx 2911 10 . . . cord-010092-uftc8inx 2912 1 The the DT cord-010092-uftc8inx 2912 2 3 3 CD cord-010092-uftc8inx 2912 3 rd rd NNP cord-010092-uftc8inx 2912 4 treated treated JJ cord-010092-uftc8inx 2912 5 woman woman NN cord-010092-uftc8inx 2912 6 entered enter VBD cord-010092-uftc8inx 2912 7 the the DT cord-010092-uftc8inx 2912 8 program program NN cord-010092-uftc8inx 2912 9 in in IN cord-010092-uftc8inx 2912 10 35 35 CD cord-010092-uftc8inx 2912 11 gw gw NNS cord-010092-uftc8inx 2912 12 ( ( -LRB- cord-010092-uftc8inx 2912 13 anti anti NNP cord-010092-uftc8inx 2912 14 - - NNP cord-010092-uftc8inx 2912 15 HPA-1a HPA-1a NNP cord-010092-uftc8inx 2912 16 concentration concentration NN cord-010092-uftc8inx 2912 17 was be VBD cord-010092-uftc8inx 2912 18 high high JJ cord-010092-uftc8inx 2912 19 22.64 22.64 CD cord-010092-uftc8inx 2912 20 IU IU NNP cord-010092-uftc8inx 2912 21 / / SYM cord-010092-uftc8inx 2912 22 ml ml NN cord-010092-uftc8inx 2912 23 ) ) -RRB- cord-010092-uftc8inx 2912 24 . . . cord-010092-uftc8inx 2913 1 She -PRON- PRP cord-010092-uftc8inx 2913 2 obtained obtain VBD cord-010092-uftc8inx 2913 3 one one CD cord-010092-uftc8inx 2913 4 injection injection NN cord-010092-uftc8inx 2913 5 of of IN cord-010092-uftc8inx 2913 6 IVIg IVIg NNP cord-010092-uftc8inx 2913 7 . . . cord-010092-uftc8inx 2914 1 Her -PRON- PRP$ cord-010092-uftc8inx 2914 2 baby baby NN cord-010092-uftc8inx 2914 3 was be VBD cord-010092-uftc8inx 2914 4 born bear VBN cord-010092-uftc8inx 2914 5 with with IN cord-010092-uftc8inx 2914 6 mild mild JJ cord-010092-uftc8inx 2914 7 thrombocytopenia thrombocytopenia NN cord-010092-uftc8inx 2914 8 with with IN cord-010092-uftc8inx 2914 9 no no DT cord-010092-uftc8inx 2914 10 ICH ICH NNP cord-010092-uftc8inx 2914 11 . . . cord-010092-uftc8inx 2915 1 Severe severe JJ cord-010092-uftc8inx 2915 2 FNAIT FNAIT NNS cord-010092-uftc8inx 2915 3 occurred occur VBD cord-010092-uftc8inx 2915 4 in in IN cord-010092-uftc8inx 2915 5 5/49 5/49 CD cord-010092-uftc8inx 2915 6 newborns newborn NNS cord-010092-uftc8inx 2915 7 : : : cord-010092-uftc8inx 2915 8 in in IN cord-010092-uftc8inx 2915 9 3 3 CD cord-010092-uftc8inx 2915 10 with with IN cord-010092-uftc8inx 2915 11 anti anti NNP cord-010092-uftc8inx 2915 12 - - NNP cord-010092-uftc8inx 2915 13 HPA-1a HPA-1a NNP cord-010092-uftc8inx 2915 14 detected detect VBD cord-010092-uftc8inx 2915 15 in in IN cord-010092-uftc8inx 2915 16 PAKLx PAKLx NNP cord-010092-uftc8inx 2915 17 only only RB cord-010092-uftc8inx 2915 18 and and CC cord-010092-uftc8inx 2915 19 in in IN cord-010092-uftc8inx 2915 20 2 2 CD cord-010092-uftc8inx 2915 21 with with IN cord-010092-uftc8inx 2915 22 antibody antibody NN cord-010092-uftc8inx 2915 23 concentration concentration NN cord-010092-uftc8inx 2915 24 in in IN cord-010092-uftc8inx 2915 25 MAIPA MAIPA NNP cord-010092-uftc8inx 2916 1 -1 -1 . cord-010092-uftc8inx 2917 1 st st NNP cord-010092-uftc8inx 2917 2 : : : cord-010092-uftc8inx 2917 3 6.86/12.91/ 6.86/12.91/ CD cord-010092-uftc8inx 2917 4 23.36 23.36 CD cord-010092-uftc8inx 2917 5 at at IN cord-010092-uftc8inx 2917 6 28/32/38 28/32/38 CD cord-010092-uftc8inx 2917 7 th th XX cord-010092-uftc8inx 2917 8 gw gw NNP cord-010092-uftc8inx 2917 9 respectively respectively RB cord-010092-uftc8inx 2917 10 ; ; : cord-010092-uftc8inx 2917 11 2 2 CD cord-010092-uftc8inx 2917 12 nd nd NNP cord-010092-uftc8inx 2917 13 : : : cord-010092-uftc8inx 2917 14 8.85/17.58 8.85/17.58 CD cord-010092-uftc8inx 2917 15 at at IN cord-010092-uftc8inx 2917 16 32/38 32/38 CD cord-010092-uftc8inx 2917 17 th th XX cord-010092-uftc8inx 2917 18 gw gw NNP cord-010092-uftc8inx 2917 19 respectively respectively RB cord-010092-uftc8inx 2917 20 . . . cord-010092-uftc8inx 2918 1 ICH ICH NNP cord-010092-uftc8inx 2918 2 was be VBD cord-010092-uftc8inx 2918 3 observed observe VBN cord-010092-uftc8inx 2918 4 in in IN cord-010092-uftc8inx 2918 5 all all DT cord-010092-uftc8inx 2918 6 of of IN cord-010092-uftc8inx 2918 7 them -PRON- PRP cord-010092-uftc8inx 2918 8 ; ; : cord-010092-uftc8inx 2918 9 PLT PLT NNP cord-010092-uftc8inx 2918 10 count count NN cord-010092-uftc8inx 2918 11 was be VBD cord-010092-uftc8inx 2918 12 < < NNP cord-010092-uftc8inx 2918 13 50x10 50x10 CD cord-010092-uftc8inx 2918 14 9 9 CD cord-010092-uftc8inx 2918 15 in in IN cord-010092-uftc8inx 2918 16 four four CD cord-010092-uftc8inx 2918 17 , , , cord-010092-uftc8inx 2919 1 56 56 CD cord-010092-uftc8inx 2919 2 9 9 CD cord-010092-uftc8inx 2919 3 10 10 CD cord-010092-uftc8inx 2919 4 9 9 CD cord-010092-uftc8inx 2919 5 / / SYM cord-010092-uftc8inx 2919 6 in in IN cord-010092-uftc8inx 2919 7 one one CD cord-010092-uftc8inx 2919 8 . . . cord-010092-uftc8inx 2920 1 Summary Summary NNP cord-010092-uftc8inx 2920 2 / / SYM cord-010092-uftc8inx 2920 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 2920 4 : : : cord-010092-uftc8inx 2921 1 1/ 1/ CD cord-010092-uftc8inx 2921 2 the the DT cord-010092-uftc8inx 2921 3 severe severe JJ cord-010092-uftc8inx 2921 4 thrombocytopenia thrombocytopenia NN cord-010092-uftc8inx 2921 5 due due JJ cord-010092-uftc8inx 2921 6 to to IN cord-010092-uftc8inx 2921 7 anti anti JJ cord-010092-uftc8inx 2921 8 - - JJ cord-010092-uftc8inx 2921 9 HPA-1a HPA-1a NNP cord-010092-uftc8inx 2921 10 alloimmunisation alloimmunisation NN cord-010092-uftc8inx 2921 11 in in IN cord-010092-uftc8inx 2921 12 our -PRON- PRP$ cord-010092-uftc8inx 2921 13 prospective prospective JJ cord-010092-uftc8inx 2921 14 study study NN cord-010092-uftc8inx 2921 15 occurred occur VBD cord-010092-uftc8inx 2921 16 in in IN cord-010092-uftc8inx 2921 17 2/10 2/10 CD cord-010092-uftc8inx 2921 18 000 000 CD cord-010092-uftc8inx 2921 19 pregnancies pregnancy NNS cord-010092-uftc8inx 2921 20 2/ 2/ CD cord-010092-uftc8inx 2922 1 The the DT cord-010092-uftc8inx 2922 2 PAKLx PAKLx NNS cord-010092-uftc8inx 2922 3 could could MD cord-010092-uftc8inx 2922 4 improve improve VB cord-010092-uftc8inx 2922 5 anti anti JJ cord-010092-uftc8inx 2922 6 - - JJ cord-010092-uftc8inx 2922 7 HPA hpa JJ cord-010092-uftc8inx 2922 8 detection detection NN cord-010092-uftc8inx 2922 9 in in IN cord-010092-uftc8inx 2922 10 the the DT cord-010092-uftc8inx 2922 11 screening screening NN cord-010092-uftc8inx 2922 12 program program NN cord-010092-uftc8inx 2922 13 and and CC cord-010092-uftc8inx 2922 14 should should MD cord-010092-uftc8inx 2922 15 be be VB cord-010092-uftc8inx 2922 16 considered consider VBN cord-010092-uftc8inx 2922 17 as as IN cord-010092-uftc8inx 2922 18 an an DT cord-010092-uftc8inx 2922 19 additional additional JJ cord-010092-uftc8inx 2922 20 diagnostic diagnostic JJ cord-010092-uftc8inx 2922 21 test test NN cord-010092-uftc8inx 2922 22 , , , cord-010092-uftc8inx 2922 23 if if IN cord-010092-uftc8inx 2922 24 MAIPA MAIPA NNP cord-010092-uftc8inx 2922 25 result result NN cord-010092-uftc8inx 2922 26 is be VBZ cord-010092-uftc8inx 2922 27 negative negative JJ cord-010092-uftc8inx 2922 28 3/ 3/ CD cord-010092-uftc8inx 2923 1 The the DT cord-010092-uftc8inx 2923 2 HPA-1a HPA-1a NNP cord-010092-uftc8inx 2923 3 alloimmunisation alloimmunisation NN cord-010092-uftc8inx 2923 4 frequency frequency NN cord-010092-uftc8inx 2923 5 is be VBZ cord-010092-uftc8inx 2923 6 higher high JJR cord-010092-uftc8inx 2923 7 in in IN cord-010092-uftc8inx 2923 8 pregnancies pregnancy NNS cord-010092-uftc8inx 2923 9 with with IN cord-010092-uftc8inx 2923 10 male male JJ cord-010092-uftc8inx 2923 11 than than IN cord-010092-uftc8inx 2923 12 female female JJ cord-010092-uftc8inx 2923 13 fetus fetus NN cord-010092-uftc8inx 2923 14 . . . cord-010092-uftc8inx 2924 1 Background background NN cord-010092-uftc8inx 2924 2 : : : cord-010092-uftc8inx 2925 1 Foeto foeto NN cord-010092-uftc8inx 2925 2 - - HYPH cord-010092-uftc8inx 2925 3 maternal maternal JJ cord-010092-uftc8inx 2925 4 platelet platelet NN cord-010092-uftc8inx 2925 5 alloimmunization alloimmunization NN cord-010092-uftc8inx 2925 6 ( ( -LRB- cord-010092-uftc8inx 2925 7 FMPAI FMPAI NNP cord-010092-uftc8inx 2925 8 ) ) -RRB- cord-010092-uftc8inx 2925 9 is be VBZ cord-010092-uftc8inx 2925 10 mainly mainly RB cord-010092-uftc8inx 2925 11 characterized characterize VBN cord-010092-uftc8inx 2925 12 by by IN cord-010092-uftc8inx 2925 13 foetal foetal JJ cord-010092-uftc8inx 2925 14 and and CC cord-010092-uftc8inx 2925 15 / / SYM cord-010092-uftc8inx 2925 16 or or CC cord-010092-uftc8inx 2925 17 neonatal neonatal JJ cord-010092-uftc8inx 2925 18 thrombocytopenia thrombocytopenia NN cord-010092-uftc8inx 2925 19 ( ( -LRB- cord-010092-uftc8inx 2925 20 FNAIT FNAIT NNP cord-010092-uftc8inx 2925 21 ) ) -RRB- cord-010092-uftc8inx 2925 22 , , , cord-010092-uftc8inx 2925 23 sometimes sometimes RB cord-010092-uftc8inx 2925 24 revealed reveal VBN cord-010092-uftc8inx 2925 25 by by IN cord-010092-uftc8inx 2925 26 intracranial intracranial JJ cord-010092-uftc8inx 2925 27 hemorrhage hemorrhage NN cord-010092-uftc8inx 2925 28 ( ( -LRB- cord-010092-uftc8inx 2925 29 ICH ICH NNP cord-010092-uftc8inx 2925 30 ) ) -RRB- cord-010092-uftc8inx 2925 31 or or CC cord-010092-uftc8inx 2925 32 even even RB cord-010092-uftc8inx 2925 33 by by IN cord-010092-uftc8inx 2925 34 foetal foetal JJ cord-010092-uftc8inx 2925 35 death death NN cord-010092-uftc8inx 2925 36 in in IN cord-010092-uftc8inx 2925 37 utero utero NN cord-010092-uftc8inx 2925 38 ( ( -LRB- cord-010092-uftc8inx 2925 39 FDIU FDIU NNP cord-010092-uftc8inx 2925 40 ) ) -RRB- cord-010092-uftc8inx 2925 41 . . . cord-010092-uftc8inx 2926 1 The the DT cord-010092-uftc8inx 2926 2 experience experience NN cord-010092-uftc8inx 2926 3 of of IN cord-010092-uftc8inx 2926 4 the the DT cord-010092-uftc8inx 2926 5 PNIL PNIL NNP cord-010092-uftc8inx 2926 6 Milwaukee Milwaukee NNP cord-010092-uftc8inx 2926 7 ( ( -LRB- cord-010092-uftc8inx 2926 8 USA USA NNP cord-010092-uftc8inx 2926 9 ) ) -RRB- cord-010092-uftc8inx 2926 10 reported report VBD cord-010092-uftc8inx 2926 11 in in IN cord-010092-uftc8inx 2926 12 2014 2014 CD cord-010092-uftc8inx 2926 13 that that IN cord-010092-uftc8inx 2926 14 the the DT cord-010092-uftc8inx 2926 15 diagnosis diagnosis NN cord-010092-uftc8inx 2926 16 of of IN cord-010092-uftc8inx 2926 17 alloimmunization alloimmunization NN cord-010092-uftc8inx 2926 18 was be VBD cord-010092-uftc8inx 2926 19 carried carry VBN cord-010092-uftc8inx 2926 20 in in IN cord-010092-uftc8inx 2926 21 only only RB cord-010092-uftc8inx 2926 22 33 33 CD cord-010092-uftc8inx 2926 23 % % NN cord-010092-uftc8inx 2926 24 of of IN cord-010092-uftc8inx 2926 25 neonatal neonatal JJ cord-010092-uftc8inx 2926 26 thrombocytopenia thrombocytopenia NN cord-010092-uftc8inx 2926 27 cases case NNS cord-010092-uftc8inx 2926 28 with with IN cord-010092-uftc8inx 2926 29 a a DT cord-010092-uftc8inx 2926 30 clinical clinical JJ cord-010092-uftc8inx 2926 31 symptomatology symptomatology NN cord-010092-uftc8inx 2926 32 highly highly RB cord-010092-uftc8inx 2926 33 suggestive suggestive JJ cord-010092-uftc8inx 2926 34 of of IN cord-010092-uftc8inx 2926 35 an an DT cord-010092-uftc8inx 2926 36 alloimmune alloimmune JJ cord-010092-uftc8inx 2926 37 etiology etiology NN cord-010092-uftc8inx 2926 38 . . . cord-010092-uftc8inx 2927 1 Aims aim VBZ cord-010092-uftc8inx 2927 2 : : : cord-010092-uftc8inx 2928 1 The the DT cord-010092-uftc8inx 2928 2 aim aim NN cord-010092-uftc8inx 2928 3 of of IN cord-010092-uftc8inx 2928 4 this this DT cord-010092-uftc8inx 2928 5 two two CD cord-010092-uftc8inx 2928 6 - - HYPH cord-010092-uftc8inx 2928 7 year year NN cord-010092-uftc8inx 2928 8 study study NN cord-010092-uftc8inx 2928 9 was be VBD cord-010092-uftc8inx 2928 10 i i NN cord-010092-uftc8inx 2928 11 ) ) -RRB- cord-010092-uftc8inx 2928 12 to to TO cord-010092-uftc8inx 2928 13 determine determine VB cord-010092-uftc8inx 2928 14 the the DT cord-010092-uftc8inx 2928 15 frequency frequency NN cord-010092-uftc8inx 2928 16 of of IN cord-010092-uftc8inx 2928 17 platelet platelet NN cord-010092-uftc8inx 2928 18 incompatibilities incompatibility NNS cord-010092-uftc8inx 2928 19 in in IN cord-010092-uftc8inx 2928 20 FNAIT FNAIT NNP cord-010092-uftc8inx 2928 21 , , , cord-010092-uftc8inx 2928 22 ICH ICH NNP cord-010092-uftc8inx 2928 23 and and CC cord-010092-uftc8inx 2928 24 FDIU FDIU NNP cord-010092-uftc8inx 2928 25 and and CC cord-010092-uftc8inx 2928 26 ii ii LS cord-010092-uftc8inx 2928 27 ) ) -RRB- cord-010092-uftc8inx 2928 28 to to TO cord-010092-uftc8inx 2928 29 evaluate evaluate VB cord-010092-uftc8inx 2928 30 the the DT cord-010092-uftc8inx 2928 31 frequency frequency NN cord-010092-uftc8inx 2928 32 of of IN cord-010092-uftc8inx 2928 33 detectable detectable JJ cord-010092-uftc8inx 2928 34 platelet platelet NN cord-010092-uftc8inx 2928 35 alloantibodies alloantibody NNS cord-010092-uftc8inx 2928 36 ( ( -LRB- cord-010092-uftc8inx 2928 37 alloAb alloAb NNP cord-010092-uftc8inx 2928 38 ) ) -RRB- cord-010092-uftc8inx 2928 39 and and CC cord-010092-uftc8inx 2928 40 their -PRON- PRP$ cord-010092-uftc8inx 2928 41 specificity specificity NN cord-010092-uftc8inx 2928 42 in in IN cord-010092-uftc8inx 2928 43 cases case NNS cord-010092-uftc8inx 2928 44 of of IN cord-010092-uftc8inx 2928 45 incompatibility incompatibility NN cord-010092-uftc8inx 2928 46 . . . cord-010092-uftc8inx 2929 1 Methods method NNS cord-010092-uftc8inx 2929 2 : : : cord-010092-uftc8inx 2929 3 Platelet platelet NN cord-010092-uftc8inx 2929 4 genotyping genotyping NN cord-010092-uftc8inx 2929 5 was be VBD cord-010092-uftc8inx 2929 6 performed perform VBN cord-010092-uftc8inx 2929 7 by by IN cord-010092-uftc8inx 2929 8 HPA HPA NNP cord-010092-uftc8inx 2929 9 Beadchip Beadchip NNP cord-010092-uftc8inx 2929 10 Genotyping Genotyping NNP cord-010092-uftc8inx 2929 11 kit kit NN cord-010092-uftc8inx 2929 12 ( ( -LRB- cord-010092-uftc8inx 2929 13 BioArray BioArray NNP cord-010092-uftc8inx 2929 14 Solutions Solutions NNPS cord-010092-uftc8inx 2929 15 , , , cord-010092-uftc8inx 2929 16 Immucor Immucor NNP cord-010092-uftc8inx 2929 17 , , , cord-010092-uftc8inx 2929 18 Warren Warren NNP cord-010092-uftc8inx 2929 19 , , , cord-010092-uftc8inx 2929 20 NJ NJ NNP cord-010092-uftc8inx 2929 21 ) ) -RRB- cord-010092-uftc8inx 2929 22 . . . cord-010092-uftc8inx 2930 1 Serology serology NN cord-010092-uftc8inx 2930 2 investigation investigation NN cord-010092-uftc8inx 2930 3 was be VBD cord-010092-uftc8inx 2930 4 carried carry VBN cord-010092-uftc8inx 2930 5 out out RP cord-010092-uftc8inx 2930 6 by by IN cord-010092-uftc8inx 2930 7 3 3 CD cord-010092-uftc8inx 2930 8 different different JJ cord-010092-uftc8inx 2930 9 methods method NNS cord-010092-uftc8inx 2930 10 : : : cord-010092-uftc8inx 2930 11 Complete complete VB cord-010092-uftc8inx 2930 12 MAIPA MAIPA NNP cord-010092-uftc8inx 2930 13 Kit kit NN cord-010092-uftc8inx 2930 14 ( ( -LRB- cord-010092-uftc8inx 2930 15 apDia apDia NNP cord-010092-uftc8inx 2930 16 bvba bvba NNP cord-010092-uftc8inx 2930 17 , , , cord-010092-uftc8inx 2930 18 Turnhout Turnhout NNP cord-010092-uftc8inx 2930 19 , , , cord-010092-uftc8inx 2930 20 Belgium Belgium NNP cord-010092-uftc8inx 2930 21 ) ) -RRB- cord-010092-uftc8inx 2930 22 , , , cord-010092-uftc8inx 2930 23 Pack Pack NNP cord-010092-uftc8inx 2930 24 LxTM LxTM NNP cord-010092-uftc8inx 2930 25 Assay Assay NNP cord-010092-uftc8inx 2930 26 ( ( -LRB- cord-010092-uftc8inx 2930 27 Immucor Immucor NNP cord-010092-uftc8inx 2930 28 GTI GTI NNP cord-010092-uftc8inx 2930 29 Diagnostics Diagnostics NNP cord-010092-uftc8inx 2930 30 , , , cord-010092-uftc8inx 2930 31 Waukesha Waukesha NNP cord-010092-uftc8inx 2930 32 , , , cord-010092-uftc8inx 2930 33 WI WI NNP cord-010092-uftc8inx 2930 34 ) ) -RRB- cord-010092-uftc8inx 2930 35 and and CC cord-010092-uftc8inx 2930 36 « « `` cord-010092-uftc8inx 2930 37 in in IN cord-010092-uftc8inx 2930 38 house house NN cord-010092-uftc8inx 2930 39 » » `` cord-010092-uftc8inx 2930 40 MAIPA MAIPA NNP cord-010092-uftc8inx 2930 41 . . . cord-010092-uftc8inx 2931 1 All all DT cord-010092-uftc8inx 2931 2 2017 2017 CD cord-010092-uftc8inx 2931 3 and and CC cord-010092-uftc8inx 2931 4 2018 2018 CD cord-010092-uftc8inx 2931 5 data datum NNS cord-010092-uftc8inx 2931 6 were be VBD cord-010092-uftc8inx 2931 7 collected collect VBN cord-010092-uftc8inx 2931 8 using use VBG cord-010092-uftc8inx 2931 9 the the DT cord-010092-uftc8inx 2931 10 Laboratory Laboratory NNP cord-010092-uftc8inx 2931 11 Information Information NNP cord-010092-uftc8inx 2931 12 Management Management NNP cord-010092-uftc8inx 2931 13 System System NNP cord-010092-uftc8inx 2931 14 . . . cord-010092-uftc8inx 2932 1 Results result NNS cord-010092-uftc8inx 2932 2 : : : cord-010092-uftc8inx 2933 1 544 544 CD cord-010092-uftc8inx 2933 2 patient patient NN cord-010092-uftc8inx 2933 3 files file NNS cord-010092-uftc8inx 2933 4 were be VBD cord-010092-uftc8inx 2933 5 analyzed analyze VBN cord-010092-uftc8inx 2933 6 . . . cord-010092-uftc8inx 2934 1 No no DT cord-010092-uftc8inx 2934 2 incompatibility incompatibility NN cord-010092-uftc8inx 2934 3 is be VBZ cord-010092-uftc8inx 2934 4 demonstrated demonstrate VBN cord-010092-uftc8inx 2934 5 in in IN cord-010092-uftc8inx 2934 6 HPA-1 HPA-1 NNP cord-010092-uftc8inx 2934 7 to to IN cord-010092-uftc8inx 2934 8 -9 -9 NNP cord-010092-uftc8inx 2934 9 , , , cord-010092-uftc8inx 2934 10 -11 -11 '' cord-010092-uftc8inx 2934 11 and and CC cord-010092-uftc8inx 2934 12 -15 -15 CD cord-010092-uftc8inx 2934 13 systems system NNS cord-010092-uftc8inx 2934 14 in in IN cord-010092-uftc8inx 2934 15 19.3 19.3 CD cord-010092-uftc8inx 2934 16 % % NN cord-010092-uftc8inx 2934 17 ( ( -LRB- cord-010092-uftc8inx 2934 18 n n NN cord-010092-uftc8inx 2934 19 = = SYM cord-010092-uftc8inx 2934 20 105 105 CD cord-010092-uftc8inx 2934 21 ) ) -RRB- cord-010092-uftc8inx 2934 22 . . . cord-010092-uftc8inx 2935 1 HPA-1 HPA-1 NNP cord-010092-uftc8inx 2935 2 and and CC cord-010092-uftc8inx 2935 3 / / SYM cord-010092-uftc8inx 2935 4 or or CC cord-010092-uftc8inx 2935 5 3 3 CD cord-010092-uftc8inx 2935 6 and and CC cord-010092-uftc8inx 2935 7 / / SYM cord-010092-uftc8inx 2935 8 or or CC cord-010092-uftc8inx 2935 9 5 5 CD cord-010092-uftc8inx 2935 10 incompatibilities incompatibility NNS cord-010092-uftc8inx 2935 11 were be VBD cord-010092-uftc8inx 2935 12 found find VBN cord-010092-uftc8inx 2935 13 in in IN cord-010092-uftc8inx 2935 14 271 271 CD cord-010092-uftc8inx 2935 15 cases case NNS cord-010092-uftc8inx 2935 16 ( ( -LRB- cord-010092-uftc8inx 2935 17 49.8 49.8 CD cord-010092-uftc8inx 2935 18 % % NN cord-010092-uftc8inx 2935 19 ) ) -RRB- cord-010092-uftc8inx 2935 20 , , , cord-010092-uftc8inx 2935 21 HPA-2 HPA-2 NNP cord-010092-uftc8inx 2935 22 and and CC cord-010092-uftc8inx 2935 23 / / SYM cord-010092-uftc8inx 2935 24 or or CC cord-010092-uftc8inx 2935 25 15 15 CD cord-010092-uftc8inx 2935 26 in in IN cord-010092-uftc8inx 2935 27 87 87 CD cord-010092-uftc8inx 2935 28 cases case NNS cord-010092-uftc8inx 2935 29 ( ( -LRB- cord-010092-uftc8inx 2935 30 16 16 CD cord-010092-uftc8inx 2935 31 % % NN cord-010092-uftc8inx 2935 32 ) ) -RRB- cord-010092-uftc8inx 2935 33 . . . cord-010092-uftc8inx 2936 1 Platelet platelet NN cord-010092-uftc8inx 2936 2 alloimmunization alloimmunization NN cord-010092-uftc8inx 2936 3 was be VBD cord-010092-uftc8inx 2936 4 globally globally RB cord-010092-uftc8inx 2936 5 confirmed confirm VBN cord-010092-uftc8inx 2936 6 in in IN cord-010092-uftc8inx 2936 7 only only RB cord-010092-uftc8inx 2936 8 10.6 10.6 CD cord-010092-uftc8inx 2936 9 % % NN cord-010092-uftc8inx 2936 10 of of IN cord-010092-uftc8inx 2936 11 the the DT cord-010092-uftc8inx 2936 12 cases case NNS cord-010092-uftc8inx 2936 13 . . . cord-010092-uftc8inx 2937 1 58 58 CD cord-010092-uftc8inx 2937 2 platelet platelet NN cord-010092-uftc8inx 2937 3 alloAbs alloAbs NNP cord-010092-uftc8inx 2937 4 were be VBD cord-010092-uftc8inx 2937 5 identified identify VBN cord-010092-uftc8inx 2937 6 regardless regardless RB cord-010092-uftc8inx 2937 7 of of IN cord-010092-uftc8inx 2937 8 clinical clinical JJ cord-010092-uftc8inx 2937 9 manifestations manifestation NNS cord-010092-uftc8inx 2937 10 : : : cord-010092-uftc8inx 2937 11 24 24 CD cord-010092-uftc8inx 2937 12 anti anti NNS cord-010092-uftc8inx 2937 13 - - NNP cord-010092-uftc8inx 2937 14 HPA-1a HPA-1a NNP cord-010092-uftc8inx 2937 15 ( ( -LRB- cord-010092-uftc8inx 2937 16 41.4 41.4 CD cord-010092-uftc8inx 2937 17 % % NN cord-010092-uftc8inx 2937 18 ) ) -RRB- cord-010092-uftc8inx 2937 19 , , , cord-010092-uftc8inx 2937 20 20 20 CD cord-010092-uftc8inx 2937 21 anti anti NNS cord-010092-uftc8inx 2937 22 - - JJ cord-010092-uftc8inx 2937 23 HPA-5b HPA-5b NNP cord-010092-uftc8inx 2937 24 ( ( -LRB- cord-010092-uftc8inx 2937 25 34.5 34.5 CD cord-010092-uftc8inx 2937 26 % % NN cord-010092-uftc8inx 2937 27 ) ) -RRB- cord-010092-uftc8inx 2937 28 , , , cord-010092-uftc8inx 2937 29 8 8 CD cord-010092-uftc8inx 2937 30 anti anti JJ cord-010092-uftc8inx 2937 31 - - JJ cord-010092-uftc8inx 2937 32 CD109 cd109 JJ cord-010092-uftc8inx 2937 33 ( ( -LRB- cord-010092-uftc8inx 2937 34 13.8 13.8 CD cord-010092-uftc8inx 2937 35 % % NN cord-010092-uftc8inx 2937 36 ) ) -RRB- cord-010092-uftc8inx 2937 37 , , , cord-010092-uftc8inx 2937 38 2 2 CD cord-010092-uftc8inx 2937 39 anti anti NNP cord-010092-uftc8inx 2937 40 - - JJ cord-010092-uftc8inx 2937 41 HPA-5a hpa-5a JJ cord-010092-uftc8inx 2937 42 and and CC cord-010092-uftc8inx 2937 43 anti anti JJ cord-010092-uftc8inx 2937 44 - - JJ cord-010092-uftc8inx 2937 45 HPA-15b hpa-15b JJ cord-010092-uftc8inx 2937 46 ( ( -LRB- cord-010092-uftc8inx 2937 47 3.4 3.4 CD cord-010092-uftc8inx 2937 48 % % NN cord-010092-uftc8inx 2937 49 respectively respectively RB cord-010092-uftc8inx 2937 50 ) ) -RRB- cord-010092-uftc8inx 2937 51 and and CC cord-010092-uftc8inx 2937 52 1 1 CD cord-010092-uftc8inx 2937 53 anti anti NNP cord-010092-uftc8inx 2937 54 - - NNP cord-010092-uftc8inx 2937 55 HPA-1b hpa-1b JJ cord-010092-uftc8inx 2937 56 and and CC cord-010092-uftc8inx 2937 57 anti anti JJ cord-010092-uftc8inx 2937 58 - - JJ cord-010092-uftc8inx 2937 59 CD36 CD36 NNP cord-010092-uftc8inx 2937 60 ( ( -LRB- cord-010092-uftc8inx 2937 61 1.7 1.7 CD cord-010092-uftc8inx 2937 62 % % NN cord-010092-uftc8inx 2937 63 respectively respectively RB cord-010092-uftc8inx 2937 64 ) ) -RRB- cord-010092-uftc8inx 2937 65 . . . cord-010092-uftc8inx 2938 1 40 40 CD cord-010092-uftc8inx 2938 2 alloAbs alloab NNS cord-010092-uftc8inx 2938 3 were be VBD cord-010092-uftc8inx 2938 4 found find VBN cord-010092-uftc8inx 2938 5 in in IN cord-010092-uftc8inx 2938 6 the the DT cord-010092-uftc8inx 2938 7 context context NN cord-010092-uftc8inx 2938 8 of of IN cord-010092-uftc8inx 2938 9 neonatal neonatal JJ cord-010092-uftc8inx 2938 10 thrombocytopenia thrombocytopenia NN cord-010092-uftc8inx 2938 11 , , , cord-010092-uftc8inx 2938 12 6 6 CD cord-010092-uftc8inx 2938 13 in in IN cord-010092-uftc8inx 2938 14 ICH ICH NNP cord-010092-uftc8inx 2938 15 and and CC cord-010092-uftc8inx 2938 16 10 10 CD cord-010092-uftc8inx 2938 17 in in IN cord-010092-uftc8inx 2938 18 FDIU FDIU NNP cord-010092-uftc8inx 2938 19 , , , cord-010092-uftc8inx 2938 20 and and CC cord-010092-uftc8inx 2938 21 1 1 CD cord-010092-uftc8inx 2938 22 in in IN cord-010092-uftc8inx 2938 23 a a DT cord-010092-uftc8inx 2938 24 follow follow NN cord-010092-uftc8inx 2938 25 - - HYPH cord-010092-uftc8inx 2938 26 up up NN cord-010092-uftc8inx 2938 27 of of IN cord-010092-uftc8inx 2938 28 pregnancy pregnancy NN cord-010092-uftc8inx 2938 29 . . . cord-010092-uftc8inx 2939 1 Even even RB cord-010092-uftc8inx 2939 2 if if IN cord-010092-uftc8inx 2939 3 no no DT cord-010092-uftc8inx 2939 4 anti anti JJ cord-010092-uftc8inx 2939 5 - - JJ cord-010092-uftc8inx 2939 6 HPA-3 hpa-3 JJ cord-010092-uftc8inx 2939 7 alloAb alloAb NNP cord-010092-uftc8inx 2939 8 could could MD cord-010092-uftc8inx 2939 9 be be VB cord-010092-uftc8inx 2939 10 identified identify VBN cord-010092-uftc8inx 2939 11 , , , cord-010092-uftc8inx 2939 12 the the DT cord-010092-uftc8inx 2939 13 incompatibility incompatibility NN cord-010092-uftc8inx 2939 14 in in IN cord-010092-uftc8inx 2939 15 this this DT cord-010092-uftc8inx 2939 16 system system NN cord-010092-uftc8inx 2939 17 was be VBD cord-010092-uftc8inx 2939 18 highly highly RB cord-010092-uftc8inx 2939 19 associated associate VBN cord-010092-uftc8inx 2939 20 with with IN cord-010092-uftc8inx 2939 21 FNAIT FNAIT NNP cord-010092-uftc8inx 2939 22 , , , cord-010092-uftc8inx 2939 23 ICH ICH NNP cord-010092-uftc8inx 2939 24 and and CC cord-010092-uftc8inx 2939 25 FDIU FDIU NNP cord-010092-uftc8inx 2939 26 ( ( -LRB- cord-010092-uftc8inx 2939 27 n n NN cord-010092-uftc8inx 2939 28 = = SYM cord-010092-uftc8inx 2939 29 55 55 CD cord-010092-uftc8inx 2939 30 , , , cord-010092-uftc8inx 2939 31 n n NN cord-010092-uftc8inx 2939 32 = = SYM cord-010092-uftc8inx 2939 33 32 32 CD cord-010092-uftc8inx 2939 34 and and CC cord-010092-uftc8inx 2939 35 n n NN cord-010092-uftc8inx 2939 36 = = SYM cord-010092-uftc8inx 2939 37 17 17 CD cord-010092-uftc8inx 2939 38 on on IN cord-010092-uftc8inx 2939 39 114 114 CD cord-010092-uftc8inx 2939 40 cases case NNS cord-010092-uftc8inx 2939 41 ) ) -RRB- cord-010092-uftc8inx 2939 42 . . . cord-010092-uftc8inx 2940 1 Summary Summary NNP cord-010092-uftc8inx 2940 2 / / SYM cord-010092-uftc8inx 2940 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 2940 4 : : : cord-010092-uftc8inx 2941 1 This this DT cord-010092-uftc8inx 2941 2 study study NN cord-010092-uftc8inx 2941 3 strongly strongly RB cord-010092-uftc8inx 2941 4 confirmed confirm VBD cord-010092-uftc8inx 2941 5 the the DT cord-010092-uftc8inx 2941 6 known know VBN cord-010092-uftc8inx 2941 7 immunogenicity immunogenicity NN cord-010092-uftc8inx 2941 8 of of IN cord-010092-uftc8inx 2941 9 some some DT cord-010092-uftc8inx 2941 10 HPA HPA NNP cord-010092-uftc8inx 2941 11 systems system NNS cord-010092-uftc8inx 2941 12 and and CC cord-010092-uftc8inx 2941 13 highlighted highlight VBD cord-010092-uftc8inx 2941 14 overall overall RB cord-010092-uftc8inx 2941 15 the the DT cord-010092-uftc8inx 2941 16 severity severity NN cord-010092-uftc8inx 2941 17 of of IN cord-010092-uftc8inx 2941 18 HPA-3 HPA-3 NNP cord-010092-uftc8inx 2941 19 and and CC cord-010092-uftc8inx 2941 20 HPA-5 HPA-5 NNP cord-010092-uftc8inx 2941 21 incompatibilities incompatibility NNS cord-010092-uftc8inx 2941 22 . . . cord-010092-uftc8inx 2942 1 The the DT cord-010092-uftc8inx 2942 2 definite definite JJ cord-010092-uftc8inx 2942 3 diagnosis diagnosis NN cord-010092-uftc8inx 2942 4 of of IN cord-010092-uftc8inx 2942 5 FMPAI FMPAI NNP cord-010092-uftc8inx 2942 6 is be VBZ cord-010092-uftc8inx 2942 7 difficult difficult JJ cord-010092-uftc8inx 2942 8 to to TO cord-010092-uftc8inx 2942 9 make make VB cord-010092-uftc8inx 2942 10 due due IN cord-010092-uftc8inx 2942 11 to to IN cord-010092-uftc8inx 2942 12 the the DT cord-010092-uftc8inx 2942 13 present present JJ cord-010092-uftc8inx 2942 14 technical technical JJ cord-010092-uftc8inx 2942 15 difficulties difficulty NNS cord-010092-uftc8inx 2942 16 in in IN cord-010092-uftc8inx 2942 17 the the DT cord-010092-uftc8inx 2942 18 detection detection NN cord-010092-uftc8inx 2942 19 of of IN cord-010092-uftc8inx 2942 20 antibodies antibody NNS cord-010092-uftc8inx 2942 21 against against IN cord-010092-uftc8inx 2942 22 the the DT cord-010092-uftc8inx 2942 23 HPA-3 HPA-3 NNP cord-010092-uftc8inx 2942 24 and and CC cord-010092-uftc8inx 2942 25 HPA-15 HPA-15 NNP cord-010092-uftc8inx 2942 26 systems system NNS cord-010092-uftc8inx 2942 27 . . . cord-010092-uftc8inx 2943 1 However however RB cord-010092-uftc8inx 2943 2 , , , cord-010092-uftc8inx 2943 3 our -PRON- PRP$ cord-010092-uftc8inx 2943 4 results result NNS cord-010092-uftc8inx 2943 5 suggest suggest VBP cord-010092-uftc8inx 2943 6 that that IN cord-010092-uftc8inx 2943 7 special special JJ cord-010092-uftc8inx 2943 8 attention attention NN cord-010092-uftc8inx 2943 9 should should MD cord-010092-uftc8inx 2943 10 be be VB cord-010092-uftc8inx 2943 11 paid pay VBN cord-010092-uftc8inx 2943 12 to to IN cord-010092-uftc8inx 2943 13 the the DT cord-010092-uftc8inx 2943 14 management management NN cord-010092-uftc8inx 2943 15 of of IN cord-010092-uftc8inx 2943 16 pregnancies pregnancy NNS cord-010092-uftc8inx 2943 17 with with IN cord-010092-uftc8inx 2943 18 these these DT cord-010092-uftc8inx 2943 19 incompatibilities incompatibility NNS cord-010092-uftc8inx 2943 20 due due JJ cord-010092-uftc8inx 2943 21 to to IN cord-010092-uftc8inx 2943 22 the the DT cord-010092-uftc8inx 2943 23 frequency frequency NN cord-010092-uftc8inx 2943 24 of of IN cord-010092-uftc8inx 2943 25 severe severe JJ cord-010092-uftc8inx 2943 26 foetal foetal JJ cord-010092-uftc8inx 2943 27 / / SYM cord-010092-uftc8inx 2943 28 neonatal neonatal JJ cord-010092-uftc8inx 2943 29 adverse adverse JJ cord-010092-uftc8inx 2943 30 events event NNS cord-010092-uftc8inx 2943 31 . . . cord-010092-uftc8inx 2944 1 Background background NN cord-010092-uftc8inx 2944 2 : : : cord-010092-uftc8inx 2945 1 Fetal fetal JJ cord-010092-uftc8inx 2945 2 and and CC cord-010092-uftc8inx 2945 3 neonatal neonatal JJ cord-010092-uftc8inx 2945 4 alloimmune alloimmune JJ cord-010092-uftc8inx 2945 5 thrombocytopenia thrombocytopenia NN cord-010092-uftc8inx 2945 6 ( ( -LRB- cord-010092-uftc8inx 2945 7 FNAIT FNAIT NNP cord-010092-uftc8inx 2945 8 ) ) -RRB- cord-010092-uftc8inx 2945 9 is be VBZ cord-010092-uftc8inx 2945 10 a a DT cord-010092-uftc8inx 2945 11 potentially potentially RB cord-010092-uftc8inx 2945 12 life life NN cord-010092-uftc8inx 2945 13 threatening threaten VBG cord-010092-uftc8inx 2945 14 disease disease NN cord-010092-uftc8inx 2945 15 caused cause VBN cord-010092-uftc8inx 2945 16 by by IN cord-010092-uftc8inx 2945 17 maternal maternal JJ cord-010092-uftc8inx 2945 18 alloantibody alloantibody NN cord-010092-uftc8inx 2945 19 formation formation NN cord-010092-uftc8inx 2945 20 against against IN cord-010092-uftc8inx 2945 21 fetal fetal JJ cord-010092-uftc8inx 2945 22 human human JJ cord-010092-uftc8inx 2945 23 platelet platelet NN cord-010092-uftc8inx 2945 24 antigens antigen NNS cord-010092-uftc8inx 2945 25 ( ( -LRB- cord-010092-uftc8inx 2945 26 HPAs HPAs NNP cord-010092-uftc8inx 2945 27 ) ) -RRB- cord-010092-uftc8inx 2945 28 , , , cord-010092-uftc8inx 2945 29 of of IN cord-010092-uftc8inx 2945 30 which which WDT cord-010092-uftc8inx 2945 31 anti anti NNP cord-010092-uftc8inx 2945 32 - - NNP cord-010092-uftc8inx 2945 33 HPA-1a HPA-1a NNP cord-010092-uftc8inx 2945 34 is be VBZ cord-010092-uftc8inx 2945 35 accountable accountable JJ cord-010092-uftc8inx 2945 36 for for IN cord-010092-uftc8inx 2945 37 the the DT cord-010092-uftc8inx 2945 38 fast fast JJ cord-010092-uftc8inx 2945 39 majority majority NN cord-010092-uftc8inx 2945 40 of of IN cord-010092-uftc8inx 2945 41 the the DT cord-010092-uftc8inx 2945 42 cases case NNS cord-010092-uftc8inx 2945 43 . . . cord-010092-uftc8inx 2946 1 Population population NN cord-010092-uftc8inx 2946 2 - - HYPH cord-010092-uftc8inx 2946 3 based base VBN cord-010092-uftc8inx 2946 4 screening screening NN cord-010092-uftc8inx 2946 5 for for IN cord-010092-uftc8inx 2946 6 FNAIT FNAIT NNP cord-010092-uftc8inx 2946 7 has have VBZ cord-010092-uftc8inx 2946 8 been be VBN cord-010092-uftc8inx 2946 9 topic topic NN cord-010092-uftc8inx 2946 10 of of IN cord-010092-uftc8inx 2946 11 debate debate NN cord-010092-uftc8inx 2946 12 for for IN cord-010092-uftc8inx 2946 13 over over IN cord-010092-uftc8inx 2946 14 decades decade NNS cord-010092-uftc8inx 2946 15 . . . cord-010092-uftc8inx 2947 1 Logistically logistically RB cord-010092-uftc8inx 2947 2 as as RB cord-010092-uftc8inx 2947 3 well well RB cord-010092-uftc8inx 2947 4 as as IN cord-010092-uftc8inx 2947 5 financially financially RB cord-010092-uftc8inx 2947 6 , , , cord-010092-uftc8inx 2947 7 the the DT cord-010092-uftc8inx 2947 8 major major JJ cord-010092-uftc8inx 2947 9 challenge challenge NN cord-010092-uftc8inx 2947 10 of of IN cord-010092-uftc8inx 2947 11 such such PDT cord-010092-uftc8inx 2947 12 a a DT cord-010092-uftc8inx 2947 13 screening screening NN cord-010092-uftc8inx 2947 14 is be VBZ cord-010092-uftc8inx 2947 15 the the DT cord-010092-uftc8inx 2947 16 typing typing NN cord-010092-uftc8inx 2947 17 of of IN cord-010092-uftc8inx 2947 18 pregnant pregnant JJ cord-010092-uftc8inx 2947 19 women woman NNS cord-010092-uftc8inx 2947 20 to to TO cord-010092-uftc8inx 2947 21 recognize recognize VB cord-010092-uftc8inx 2947 22 the the DT cord-010092-uftc8inx 2947 23 2 2 CD cord-010092-uftc8inx 2947 24 % % NN cord-010092-uftc8inx 2947 25 HPA-1a HPA-1a NNP cord-010092-uftc8inx 2947 26 negative negative JJ cord-010092-uftc8inx 2947 27 women woman NNS cord-010092-uftc8inx 2947 28 . . . cord-010092-uftc8inx 2948 1 At at IN cord-010092-uftc8inx 2948 2 present present NN cord-010092-uftc8inx 2948 3 , , , cord-010092-uftc8inx 2948 4 HPA-1a HPA-1a NNP cord-010092-uftc8inx 2948 5 typing typing NN cord-010092-uftc8inx 2948 6 is be VBZ cord-010092-uftc8inx 2948 7 mostly mostly RB cord-010092-uftc8inx 2948 8 done do VBN cord-010092-uftc8inx 2948 9 by by IN cord-010092-uftc8inx 2948 10 genotyping genotype VBG cord-010092-uftc8inx 2948 11 . . . cord-010092-uftc8inx 2949 1 For for IN cord-010092-uftc8inx 2949 2 costeffective costeffective JJ cord-010092-uftc8inx 2949 3 implementation implementation NN cord-010092-uftc8inx 2949 4 of of IN cord-010092-uftc8inx 2949 5 anti anti JJ cord-010092-uftc8inx 2949 6 - - JJ cord-010092-uftc8inx 2949 7 HPA-1a HPA-1a NNP cord-010092-uftc8inx 2949 8 screening screening NN cord-010092-uftc8inx 2949 9 there there EX cord-010092-uftc8inx 2949 10 is be VBZ cord-010092-uftc8inx 2949 11 need need NN cord-010092-uftc8inx 2949 12 for for IN cord-010092-uftc8inx 2949 13 a a DT cord-010092-uftc8inx 2949 14 high high JJ cord-010092-uftc8inx 2949 15 - - HYPH cord-010092-uftc8inx 2949 16 throughput throughput NN cord-010092-uftc8inx 2949 17 , , , cord-010092-uftc8inx 2949 18 quick quick JJ cord-010092-uftc8inx 2949 19 and and CC cord-010092-uftc8inx 2949 20 low low JJ cord-010092-uftc8inx 2949 21 - - HYPH cord-010092-uftc8inx 2949 22 cost cost NN cord-010092-uftc8inx 2949 23 phenotyping phenotyping NN cord-010092-uftc8inx 2949 24 assay assay NN cord-010092-uftc8inx 2949 25 . . . cord-010092-uftc8inx 2950 1 Aims aim VBZ cord-010092-uftc8inx 2950 2 : : : cord-010092-uftc8inx 2951 1 The the DT cord-010092-uftc8inx 2951 2 aim aim NN cord-010092-uftc8inx 2951 3 was be VBD cord-010092-uftc8inx 2951 4 to to TO cord-010092-uftc8inx 2951 5 develop develop VB cord-010092-uftc8inx 2951 6 a a DT cord-010092-uftc8inx 2951 7 high high JJ cord-010092-uftc8inx 2951 8 - - HYPH cord-010092-uftc8inx 2951 9 throughput throughput NN cord-010092-uftc8inx 2951 10 , , , cord-010092-uftc8inx 2951 11 quick quick JJ cord-010092-uftc8inx 2951 12 and and CC cord-010092-uftc8inx 2951 13 low low JJ cord-010092-uftc8inx 2951 14 - - HYPH cord-010092-uftc8inx 2951 15 cost cost NN cord-010092-uftc8inx 2951 16 phenotyping phenotyping NN cord-010092-uftc8inx 2951 17 assay assay NN cord-010092-uftc8inx 2951 18 in in IN cord-010092-uftc8inx 2951 19 order order NN cord-010092-uftc8inx 2951 20 to to TO cord-010092-uftc8inx 2951 21 identify identify VB cord-010092-uftc8inx 2951 22 HPA-1a HPA-1a NNP cord-010092-uftc8inx 2951 23 negative negative JJ cord-010092-uftc8inx 2951 24 pregnant pregnant JJ cord-010092-uftc8inx 2951 25 women woman NNS cord-010092-uftc8inx 2951 26 . . . cord-010092-uftc8inx 2952 1 Methods method NNS cord-010092-uftc8inx 2952 2 : : : cord-010092-uftc8inx 2953 1 An an DT cord-010092-uftc8inx 2953 2 automated automate VBN cord-010092-uftc8inx 2953 3 sandwich sandwich NN cord-010092-uftc8inx 2953 4 ELISA ELISA NNP cord-010092-uftc8inx 2953 5 was be VBD cord-010092-uftc8inx 2953 6 developed develop VBN cord-010092-uftc8inx 2953 7 to to TO cord-010092-uftc8inx 2953 8 perform perform VB cord-010092-uftc8inx 2953 9 HPA-1a HPA-1a NNP cord-010092-uftc8inx 2953 10 phenotyping phenotyping NN cord-010092-uftc8inx 2953 11 using use VBG cord-010092-uftc8inx 2953 12 a a DT cord-010092-uftc8inx 2953 13 murine murine JJ cord-010092-uftc8inx 2953 14 monoclonal monoclonal JJ cord-010092-uftc8inx 2953 15 anti anti NNS cord-010092-uftc8inx 2953 16 - - NNS cord-010092-uftc8inx 2953 17 GPIIIa GPIIIa NNS cord-010092-uftc8inx 2953 18 as as IN cord-010092-uftc8inx 2953 19 coating coating NN cord-010092-uftc8inx 2953 20 antibody antibody NN cord-010092-uftc8inx 2953 21 and and CC cord-010092-uftc8inx 2953 22 horseradishperoxidase horseradishperoxidase NN cord-010092-uftc8inx 2953 23 - - HYPH cord-010092-uftc8inx 2953 24 conjugated conjugate VBN cord-010092-uftc8inx 2953 25 recombinant recombinant JJ cord-010092-uftc8inx 2953 26 IgG1 IgG1 NNP cord-010092-uftc8inx 2953 27 anti anti NNP cord-010092-uftc8inx 2953 28 - - NNP cord-010092-uftc8inx 2953 29 HPA-1a HPA-1a NNP cord-010092-uftc8inx 2953 30 as as IN cord-010092-uftc8inx 2953 31 detecting detect VBG cord-010092-uftc8inx 2953 32 antibody antibody NN cord-010092-uftc8inx 2953 33 . . . cord-010092-uftc8inx 2954 1 To to TO cord-010092-uftc8inx 2954 2 ensure ensure VB cord-010092-uftc8inx 2954 3 the the DT cord-010092-uftc8inx 2954 4 applicability applicability NN cord-010092-uftc8inx 2954 5 for for IN cord-010092-uftc8inx 2954 6 high high JJ cord-010092-uftc8inx 2954 7 - - HYPH cord-010092-uftc8inx 2954 8 throughput throughput NN cord-010092-uftc8inx 2954 9 testing testing NN cord-010092-uftc8inx 2954 10 in in IN cord-010092-uftc8inx 2954 11 a a DT cord-010092-uftc8inx 2954 12 potential potential JJ cord-010092-uftc8inx 2954 13 screening screening NN cord-010092-uftc8inx 2954 14 setting setting NN cord-010092-uftc8inx 2954 15 , , , cord-010092-uftc8inx 2954 16 20 20 CD cord-010092-uftc8inx 2954 17 ll will NN cord-010092-uftc8inx 2954 18 of of IN cord-010092-uftc8inx 2954 19 the the DT cord-010092-uftc8inx 2954 20 uppermost uppermost JJ cord-010092-uftc8inx 2954 21 plasma plasma NN cord-010092-uftc8inx 2954 22 of of IN cord-010092-uftc8inx 2954 23 3 3 CD cord-010092-uftc8inx 2954 24 -6 -6 JJ cord-010092-uftc8inx 2954 25 days day NNS cord-010092-uftc8inx 2954 26 - - HYPH cord-010092-uftc8inx 2954 27 old old JJ cord-010092-uftc8inx 2954 28 stored store VBN cord-010092-uftc8inx 2954 29 EDTA EDTA NNP cord-010092-uftc8inx 2954 30 anticoagulated anticoagulate VBD cord-010092-uftc8inx 2954 31 blood blood NN cord-010092-uftc8inx 2954 32 tubes tube NNS cord-010092-uftc8inx 2954 33 was be VBD cord-010092-uftc8inx 2954 34 used use VBN cord-010092-uftc8inx 2954 35 , , , cord-010092-uftc8inx 2954 36 without without IN cord-010092-uftc8inx 2954 37 first first JJ cord-010092-uftc8inx 2954 38 swirling swirl VBG cord-010092-uftc8inx 2954 39 or or CC cord-010092-uftc8inx 2954 40 spinning spin VBG cord-010092-uftc8inx 2954 41 them -PRON- PRP cord-010092-uftc8inx 2954 42 . . . cord-010092-uftc8inx 2955 1 In in IN cord-010092-uftc8inx 2955 2 two two CD cord-010092-uftc8inx 2955 3 phases phase NNS cord-010092-uftc8inx 2955 4 , , , cord-010092-uftc8inx 2955 5 samples sample NNS cord-010092-uftc8inx 2955 6 of of IN cord-010092-uftc8inx 2955 7 pregnant pregnant JJ cord-010092-uftc8inx 2955 8 women woman NNS cord-010092-uftc8inx 2955 9 were be VBD cord-010092-uftc8inx 2955 10 tested test VBN cord-010092-uftc8inx 2955 11 and and CC cord-010092-uftc8inx 2955 12 compared compare VBN cord-010092-uftc8inx 2955 13 to to IN cord-010092-uftc8inx 2955 14 an an DT cord-010092-uftc8inx 2955 15 allelic allelic JJ cord-010092-uftc8inx 2955 16 discrimination discrimination NN cord-010092-uftc8inx 2955 17 polymerase polymerase NN cord-010092-uftc8inx 2955 18 chain chain NN cord-010092-uftc8inx 2955 19 reaction reaction NN cord-010092-uftc8inx 2955 20 assay assay NN cord-010092-uftc8inx 2955 21 as as IN cord-010092-uftc8inx 2955 22 golden golden JJ cord-010092-uftc8inx 2955 23 standard standard NN cord-010092-uftc8inx 2955 24 . . . cord-010092-uftc8inx 2956 1 In in IN cord-010092-uftc8inx 2956 2 the the DT cord-010092-uftc8inx 2956 3 first first JJ cord-010092-uftc8inx 2956 4 phase phase NN cord-010092-uftc8inx 2956 5 , , , cord-010092-uftc8inx 2956 6 samples sample NNS cord-010092-uftc8inx 2956 7 from from IN cord-010092-uftc8inx 2956 8 unselected unselected JJ cord-010092-uftc8inx 2956 9 consecutive consecutive JJ cord-010092-uftc8inx 2956 10 pregnant pregnant JJ cord-010092-uftc8inx 2956 11 women woman NNS cord-010092-uftc8inx 2956 12 were be VBD cord-010092-uftc8inx 2956 13 tested test VBN cord-010092-uftc8inx 2956 14 . . . cord-010092-uftc8inx 2957 1 The the DT cord-010092-uftc8inx 2957 2 second second JJ cord-010092-uftc8inx 2957 3 phase phase NN cord-010092-uftc8inx 2957 4 was be VBD cord-010092-uftc8inx 2957 5 part part NN cord-010092-uftc8inx 2957 6 of of IN cord-010092-uftc8inx 2957 7 a a DT cord-010092-uftc8inx 2957 8 prospective prospective JJ cord-010092-uftc8inx 2957 9 screening screening NN cord-010092-uftc8inx 2957 10 study study NN cord-010092-uftc8inx 2957 11 in in IN cord-010092-uftc8inx 2957 12 pregnancy pregnancy NN cord-010092-uftc8inx 2957 13 and and CC cord-010092-uftc8inx 2957 14 confirmatory confirmatory JJ cord-010092-uftc8inx 2957 15 genotyping genotyping NN cord-010092-uftc8inx 2957 16 was be VBD cord-010092-uftc8inx 2957 17 restricted restrict VBN cord-010092-uftc8inx 2957 18 to to IN cord-010092-uftc8inx 2957 19 samples sample NNS cord-010092-uftc8inx 2957 20 with with IN cord-010092-uftc8inx 2957 21 an an DT cord-010092-uftc8inx 2957 22 arbitrary arbitrary JJ cord-010092-uftc8inx 2957 23 set set NN cord-010092-uftc8inx 2957 24 OD od NN cord-010092-uftc8inx 2958 1 < < XX cord-010092-uftc8inx 2958 2 0.500 0.500 CD cord-010092-uftc8inx 2958 3 in in IN cord-010092-uftc8inx 2958 4 the the DT cord-010092-uftc8inx 2958 5 HPA-1a HPA-1a NNP cord-010092-uftc8inx 2958 6 ELISA ELISA NNP cord-010092-uftc8inx 2958 7 . . . cord-010092-uftc8inx 2959 1 The the DT cord-010092-uftc8inx 2959 2 developed develop VBN cord-010092-uftc8inx 2959 3 ELISA ELISA NNP cord-010092-uftc8inx 2959 4 was be VBD cord-010092-uftc8inx 2959 5 optimized optimize VBN cord-010092-uftc8inx 2959 6 to to TO cord-010092-uftc8inx 2959 7 require require VB cord-010092-uftc8inx 2959 8 no no DT cord-010092-uftc8inx 2959 9 additional additional JJ cord-010092-uftc8inx 2959 10 handling handling NN cord-010092-uftc8inx 2959 11 ( ( -LRB- cord-010092-uftc8inx 2959 12 swirling swirl VBG cord-010092-uftc8inx 2959 13 or or CC cord-010092-uftc8inx 2959 14 spinning spin VBG cord-010092-uftc8inx 2959 15 ) ) -RRB- cord-010092-uftc8inx 2959 16 of of IN cord-010092-uftc8inx 2959 17 stored store VBN cord-010092-uftc8inx 2959 18 tubes tube NNS cord-010092-uftc8inx 2959 19 . . . cord-010092-uftc8inx 2960 1 During during IN cord-010092-uftc8inx 2960 2 phase phase NN cord-010092-uftc8inx 2960 3 I -PRON- PRP cord-010092-uftc8inx 2960 4 , , , cord-010092-uftc8inx 2960 5 506 506 CD cord-010092-uftc8inx 2960 6 consecutive consecutive JJ cord-010092-uftc8inx 2960 7 samples sample NNS cord-010092-uftc8inx 2960 8 were be VBD cord-010092-uftc8inx 2960 9 tested test VBN cord-010092-uftc8inx 2960 10 . . . cord-010092-uftc8inx 2961 1 In in IN cord-010092-uftc8inx 2961 2 phase phase NN cord-010092-uftc8inx 2961 3 II II NNP cord-010092-uftc8inx 2961 4 , , , cord-010092-uftc8inx 2961 5 the the DT cord-010092-uftc8inx 2961 6 HPA-1a HPA-1a NNP cord-010092-uftc8inx 2961 7 ELISA ELISA NNP cord-010092-uftc8inx 2961 8 was be VBD cord-010092-uftc8inx 2961 9 performed perform VBN cord-010092-uftc8inx 2961 10 in in IN cord-010092-uftc8inx 2961 11 another another DT cord-010092-uftc8inx 2961 12 62,171 62,171 CD cord-010092-uftc8inx 2961 13 consecutive consecutive JJ cord-010092-uftc8inx 2961 14 samples sample NNS cord-010092-uftc8inx 2961 15 , , , cord-010092-uftc8inx 2961 16 with with IN cord-010092-uftc8inx 2961 17 confirmatory confirmatory JJ cord-010092-uftc8inx 2961 18 Q Q NNP cord-010092-uftc8inx 2961 19 - - HYPH cord-010092-uftc8inx 2961 20 PCR PCR NNP cord-010092-uftc8inx 2961 21 in in IN cord-010092-uftc8inx 2961 22 1,825 1,825 CD cord-010092-uftc8inx 2961 23 . . . cord-010092-uftc8inx 2962 1 The the DT cord-010092-uftc8inx 2962 2 two two CD cord-010092-uftc8inx 2962 3 phases phase NNS cord-010092-uftc8inx 2962 4 combined combine VBN cord-010092-uftc8inx 2962 5 , , , cord-010092-uftc8inx 2962 6 samples sample NNS cord-010092-uftc8inx 2962 7 from from IN cord-010092-uftc8inx 2962 8 in in IN cord-010092-uftc8inx 2962 9 total total JJ cord-010092-uftc8inx 2962 10 1,585 1,585 CD cord-010092-uftc8inx 2962 11 HPA-1a HPA-1a NNP cord-010092-uftc8inx 2962 12 negative negative JJ cord-010092-uftc8inx 2962 13 and and CC cord-010092-uftc8inx 2962 14 823 823 CD cord-010092-uftc8inx 2962 15 HPA-1a HPA-1a NNP cord-010092-uftc8inx 2962 16 positive positive JJ cord-010092-uftc8inx 2962 17 pregnant pregnant JJ cord-010092-uftc8inx 2962 18 women woman NNS cord-010092-uftc8inx 2962 19 were be VBD cord-010092-uftc8inx 2962 20 genotyped genotype VBN cord-010092-uftc8inx 2962 21 . . . cord-010092-uftc8inx 2963 1 The the DT cord-010092-uftc8inx 2963 2 assay assay NN cord-010092-uftc8inx 2963 3 reached reach VBD cord-010092-uftc8inx 2963 4 a a DT cord-010092-uftc8inx 2963 5 100 100 CD cord-010092-uftc8inx 2963 6 % % NN cord-010092-uftc8inx 2963 7 sensitivity sensitivity NN cord-010092-uftc8inx 2963 8 with with IN cord-010092-uftc8inx 2963 9 a a DT cord-010092-uftc8inx 2963 10 cut cut NN cord-010092-uftc8inx 2963 11 - - HYPH cord-010092-uftc8inx 2963 12 off off RP cord-010092-uftc8inx 2963 13 OD od NN cord-010092-uftc8inx 2963 14 between between IN cord-010092-uftc8inx 2963 15 0.075 0.075 CD cord-010092-uftc8inx 2963 16 and and CC cord-010092-uftc8inx 2963 17 0.200 0.200 CD cord-010092-uftc8inx 2963 18 , , , cord-010092-uftc8inx 2963 19 leading lead VBG cord-010092-uftc8inx 2963 20 to to IN cord-010092-uftc8inx 2963 21 a a DT cord-010092-uftc8inx 2963 22 specificity specificity NN cord-010092-uftc8inx 2963 23 of of IN cord-010092-uftc8inx 2963 24 99.6 99.6 CD cord-010092-uftc8inx 2963 25 % % NN cord-010092-uftc8inx 2963 26 . . . cord-010092-uftc8inx 2964 1 Summary Summary NNP cord-010092-uftc8inx 2964 2 / / SYM cord-010092-uftc8inx 2964 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 2964 4 : : : cord-010092-uftc8inx 2965 1 A a DT cord-010092-uftc8inx 2965 2 quick quick JJ cord-010092-uftc8inx 2965 3 , , , cord-010092-uftc8inx 2965 4 low low JJ cord-010092-uftc8inx 2965 5 - - HYPH cord-010092-uftc8inx 2965 6 cost cost NN cord-010092-uftc8inx 2965 7 and and CC cord-010092-uftc8inx 2965 8 reliable reliable JJ cord-010092-uftc8inx 2965 9 assay assay NN cord-010092-uftc8inx 2965 10 for for IN cord-010092-uftc8inx 2965 11 HPA-1a HPA-1a NNP cord-010092-uftc8inx 2965 12 phenotyping phenotyping NN cord-010092-uftc8inx 2965 13 was be VBD cord-010092-uftc8inx 2965 14 developed develop VBN cord-010092-uftc8inx 2965 15 that that WDT cord-010092-uftc8inx 2965 16 can can MD cord-010092-uftc8inx 2965 17 be be VB cord-010092-uftc8inx 2965 18 used use VBN cord-010092-uftc8inx 2965 19 in in IN cord-010092-uftc8inx 2965 20 a a DT cord-010092-uftc8inx 2965 21 population population NN cord-010092-uftc8inx 2965 22 - - HYPH cord-010092-uftc8inx 2965 23 based base VBN cord-010092-uftc8inx 2965 24 screening screening NN cord-010092-uftc8inx 2965 25 setting set VBG cord-010092-uftc8inx 2965 26 to to TO cord-010092-uftc8inx 2965 27 select select VB cord-010092-uftc8inx 2965 28 samples sample NNS cord-010092-uftc8inx 2965 29 that that WDT cord-010092-uftc8inx 2965 30 has have VBZ cord-010092-uftc8inx 2965 31 to to TO cord-010092-uftc8inx 2965 32 be be VB cord-010092-uftc8inx 2965 33 tested test VBN cord-010092-uftc8inx 2965 34 for for IN cord-010092-uftc8inx 2965 35 the the DT cord-010092-uftc8inx 2965 36 presence presence NN cord-010092-uftc8inx 2965 37 of of IN cord-010092-uftc8inx 2965 38 anti anti JJ cord-010092-uftc8inx 2965 39 - - JJ cord-010092-uftc8inx 2965 40 HPA1a hpa1a JJ cord-010092-uftc8inx 2965 41 antibodies antibody NNS cord-010092-uftc8inx 2965 42 . . . cord-010092-uftc8inx 2966 1 Because because IN cord-010092-uftc8inx 2966 2 plasma plasma NN cord-010092-uftc8inx 2966 3 from from IN cord-010092-uftc8inx 2966 4 non non JJ cord-010092-uftc8inx 2966 5 - - JJ cord-010092-uftc8inx 2966 6 mixed mixed JJ cord-010092-uftc8inx 2966 7 or or CC cord-010092-uftc8inx 2966 8 spinned spinne VBN cord-010092-uftc8inx 2966 9 tubes tube NNS cord-010092-uftc8inx 2966 10 of of IN cord-010092-uftc8inx 2966 11 three three CD cord-010092-uftc8inx 2966 12 to to TO cord-010092-uftc8inx 2966 13 six six CD cord-010092-uftc8inx 2966 14 day day NN cord-010092-uftc8inx 2966 15 - - HYPH cord-010092-uftc8inx 2966 16 old old JJ cord-010092-uftc8inx 2966 17 samples sample NNS cord-010092-uftc8inx 2966 18 can can MD cord-010092-uftc8inx 2966 19 be be VB cord-010092-uftc8inx 2966 20 used use VBN cord-010092-uftc8inx 2966 21 , , , cord-010092-uftc8inx 2966 22 this this DT cord-010092-uftc8inx 2966 23 assay assay NN cord-010092-uftc8inx 2966 24 is be VBZ cord-010092-uftc8inx 2966 25 applicable applicable JJ cord-010092-uftc8inx 2966 26 to to IN cord-010092-uftc8inx 2966 27 settings setting NNS cord-010092-uftc8inx 2966 28 with with IN cord-010092-uftc8inx 2966 29 suboptimal suboptimal JJ cord-010092-uftc8inx 2966 30 conditions condition NNS cord-010092-uftc8inx 2966 31 . . . cord-010092-uftc8inx 2967 1 Background background NN cord-010092-uftc8inx 2967 2 : : : cord-010092-uftc8inx 2967 3 Cytomegalovirus Cytomegalovirus NNP cord-010092-uftc8inx 2967 4 ( ( -LRB- cord-010092-uftc8inx 2967 5 CMV CMV NNP cord-010092-uftc8inx 2967 6 ) ) -RRB- cord-010092-uftc8inx 2967 7 sero sero NN cord-010092-uftc8inx 2967 8 - - HYPH cord-010092-uftc8inx 2967 9 prevalence prevalence NN cord-010092-uftc8inx 2967 10 in in IN cord-010092-uftc8inx 2967 11 Ireland Ireland NNP cord-010092-uftc8inx 2967 12 is be VBZ cord-010092-uftc8inx 2967 13 lower low JJR cord-010092-uftc8inx 2967 14 than than IN cord-010092-uftc8inx 2967 15 that that DT cord-010092-uftc8inx 2967 16 which which WDT cord-010092-uftc8inx 2967 17 is be VBZ cord-010092-uftc8inx 2967 18 reported report VBN cord-010092-uftc8inx 2967 19 in in IN cord-010092-uftc8inx 2967 20 many many JJ cord-010092-uftc8inx 2967 21 other other JJ cord-010092-uftc8inx 2967 22 European european JJ cord-010092-uftc8inx 2967 23 countries country NNS cord-010092-uftc8inx 2967 24 . . . cord-010092-uftc8inx 2968 1 A a DT cord-010092-uftc8inx 2968 2 study study NN cord-010092-uftc8inx 2968 3 of of IN cord-010092-uftc8inx 2968 4 1047 1047 CD cord-010092-uftc8inx 2968 5 pregnant pregnant JJ cord-010092-uftc8inx 2968 6 women woman NNS cord-010092-uftc8inx 2968 7 in in IN cord-010092-uftc8inx 2968 8 2002 2002 CD cord-010092-uftc8inx 2968 9 found find VBD cord-010092-uftc8inx 2968 10 that that IN cord-010092-uftc8inx 2968 11 30.4 30.4 CD cord-010092-uftc8inx 2968 12 % % NN cord-010092-uftc8inx 2968 13 of of IN cord-010092-uftc8inx 2968 14 Irish irish JJ cord-010092-uftc8inx 2968 15 women woman NNS cord-010092-uftc8inx 2968 16 were be VBD cord-010092-uftc8inx 2968 17 CMV CMV NNP cord-010092-uftc8inx 2968 18 seropositive seropositive JJ cord-010092-uftc8inx 2968 19 in in IN cord-010092-uftc8inx 2968 20 comparison comparison NN cord-010092-uftc8inx 2968 21 to to IN cord-010092-uftc8inx 2968 22 56 56 CD cord-010092-uftc8inx 2968 23 % % NN cord-010092-uftc8inx 2968 24 from from IN cord-010092-uftc8inx 2968 25 Western Western NNP cord-010092-uftc8inx 2968 26 Europe Europe NNP cord-010092-uftc8inx 2968 27 and and CC cord-010092-uftc8inx 2968 28 92 92 CD cord-010092-uftc8inx 2968 29 % % NN cord-010092-uftc8inx 2968 30 Eastern Eastern NNP cord-010092-uftc8inx 2968 31 Europe Europe NNP cord-010092-uftc8inx 2968 32 and and CC cord-010092-uftc8inx 2968 33 97 97 CD cord-010092-uftc8inx 2968 34 % % NN cord-010092-uftc8inx 2968 35 from from IN cord-010092-uftc8inx 2968 36 Africa Africa NNP cord-010092-uftc8inx 2968 37 . . . cord-010092-uftc8inx 2969 1 An an DT cord-010092-uftc8inx 2969 2 internal internal JJ cord-010092-uftc8inx 2969 3 study study NN cord-010092-uftc8inx 2969 4 carried carry VBN cord-010092-uftc8inx 2969 5 out out RP cord-010092-uftc8inx 2969 6 by by IN cord-010092-uftc8inx 2969 7 the the DT cord-010092-uftc8inx 2969 8 Irish Irish NNP cord-010092-uftc8inx 2969 9 Blood Blood NNP cord-010092-uftc8inx 2969 10 Transfusion Transfusion NNP cord-010092-uftc8inx 2969 11 Service Service NNP cord-010092-uftc8inx 2969 12 ( ( -LRB- cord-010092-uftc8inx 2969 13 IBTS IBTS NNP cord-010092-uftc8inx 2969 14 ) ) -RRB- cord-010092-uftc8inx 2969 15 in in IN cord-010092-uftc8inx 2969 16 2010 2010 CD cord-010092-uftc8inx 2969 17 indicated indicate VBD cord-010092-uftc8inx 2969 18 the the DT cord-010092-uftc8inx 2969 19 rate rate NN cord-010092-uftc8inx 2969 20 of of IN cord-010092-uftc8inx 2969 21 CMV CMV NNP cord-010092-uftc8inx 2969 22 seropositivity seropositivity NN cord-010092-uftc8inx 2969 23 in in IN cord-010092-uftc8inx 2969 24 Irish Irish NNP cord-010092-uftc8inx 2969 25 Blood Blood NNP cord-010092-uftc8inx 2969 26 donors donor NNS cord-010092-uftc8inx 2969 27 was be VBD cord-010092-uftc8inx 2969 28 21.97 21.97 CD cord-010092-uftc8inx 2969 29 % % NN cord-010092-uftc8inx 2969 30 . . . cord-010092-uftc8inx 2970 1 Therefore therefore RB cord-010092-uftc8inx 2970 2 a a DT cord-010092-uftc8inx 2970 3 significant significant JJ cord-010092-uftc8inx 2970 4 proportion proportion NN cord-010092-uftc8inx 2970 5 of of IN cord-010092-uftc8inx 2970 6 the the DT cord-010092-uftc8inx 2970 7 Irish irish JJ cord-010092-uftc8inx 2970 8 donor donor NN cord-010092-uftc8inx 2970 9 and and CC cord-010092-uftc8inx 2970 10 recipient recipient NN cord-010092-uftc8inx 2970 11 population population NN cord-010092-uftc8inx 2970 12 are be VBP cord-010092-uftc8inx 2970 13 susceptible susceptible JJ cord-010092-uftc8inx 2970 14 to to IN cord-010092-uftc8inx 2970 15 primary primary JJ cord-010092-uftc8inx 2970 16 CMV CMV NNP cord-010092-uftc8inx 2970 17 . . . cord-010092-uftc8inx 2971 1 This this DT cord-010092-uftc8inx 2971 2 is be VBZ cord-010092-uftc8inx 2971 3 of of IN cord-010092-uftc8inx 2971 4 particular particular JJ cord-010092-uftc8inx 2971 5 concern concern NN cord-010092-uftc8inx 2971 6 for for IN cord-010092-uftc8inx 2971 7 patients patient NNS cord-010092-uftc8inx 2971 8 for for IN cord-010092-uftc8inx 2971 9 certain certain JJ cord-010092-uftc8inx 2971 10 at at IN cord-010092-uftc8inx 2971 11 - - HYPH cord-010092-uftc8inx 2971 12 risk risk NN cord-010092-uftc8inx 2971 13 groups group NNS cord-010092-uftc8inx 2971 14 such such JJ cord-010092-uftc8inx 2971 15 as as IN cord-010092-uftc8inx 2971 16 very very RB cord-010092-uftc8inx 2971 17 - - HYPH cord-010092-uftc8inx 2971 18 low low JJ cord-010092-uftc8inx 2971 19 birthweight birthweight JJ cord-010092-uftc8inx 2971 20 CMV CMV NNP cord-010092-uftc8inx 2971 21 seronegative seronegative JJ cord-010092-uftc8inx 2971 22 neonates neonate NNS cord-010092-uftc8inx 2971 23 , , , cord-010092-uftc8inx 2971 24 CMV CMV NNP cord-010092-uftc8inx 2971 25 seronegative seronegative JJ cord-010092-uftc8inx 2971 26 patients patient NNS cord-010092-uftc8inx 2971 27 undergoing undergo VBG cord-010092-uftc8inx 2971 28 transplantation transplantation NN cord-010092-uftc8inx 2971 29 and and CC cord-010092-uftc8inx 2971 30 other other JJ cord-010092-uftc8inx 2971 31 CMV CMV NNP cord-010092-uftc8inx 2971 32 seronegative seronegative JJ cord-010092-uftc8inx 2971 33 immunocompromised immunocompromised JJ cord-010092-uftc8inx 2971 34 patients patient NNS cord-010092-uftc8inx 2971 35 . . . cord-010092-uftc8inx 2972 1 This this DT cord-010092-uftc8inx 2972 2 results result VBZ cord-010092-uftc8inx 2972 3 in in IN cord-010092-uftc8inx 2972 4 a a DT cord-010092-uftc8inx 2972 5 demand demand NN cord-010092-uftc8inx 2972 6 for for IN cord-010092-uftc8inx 2972 7 the the DT cord-010092-uftc8inx 2972 8 provision provision NN cord-010092-uftc8inx 2972 9 of of IN cord-010092-uftc8inx 2972 10 CMV CMV NNP cord-010092-uftc8inx 2972 11 sero sero NN cord-010092-uftc8inx 2972 12 - - HYPH cord-010092-uftc8inx 2972 13 negative negative JJ cord-010092-uftc8inx 2972 14 blood blood NN cord-010092-uftc8inx 2972 15 components component NNS cord-010092-uftc8inx 2972 16 . . . cord-010092-uftc8inx 2973 1 In in IN cord-010092-uftc8inx 2973 2 2018 2018 CD cord-010092-uftc8inx 2973 3 the the DT cord-010092-uftc8inx 2973 4 IBTS IBTS NNP cord-010092-uftc8inx 2973 5 evaluated evaluate VBD cord-010092-uftc8inx 2973 6 the the DT cord-010092-uftc8inx 2973 7 Abbott Abbott NNP cord-010092-uftc8inx 2973 8 Alinity Alinity NNP cord-010092-uftc8inx 2973 9 s s POS cord-010092-uftc8inx 2973 10 CMV CMV NNP cord-010092-uftc8inx 2973 11 IgG igg NN cord-010092-uftc8inx 2973 12 assay assay NN cord-010092-uftc8inx 2973 13 as as IN cord-010092-uftc8inx 2973 14 a a DT cord-010092-uftc8inx 2973 15 replacement replacement NN cord-010092-uftc8inx 2973 16 for for IN cord-010092-uftc8inx 2973 17 the the DT cord-010092-uftc8inx 2973 18 CMV CMV NNP cord-010092-uftc8inx 2973 19 Mastazyme Mastazyme NNP cord-010092-uftc8inx 2973 20 EIA EIA NNP cord-010092-uftc8inx 2973 21 ( ( -LRB- cord-010092-uftc8inx 2973 22 Total total JJ cord-010092-uftc8inx 2973 23 AB AB NNP cord-010092-uftc8inx 2973 24 EIA EIA NNP cord-010092-uftc8inx 2973 25 ) ) -RRB- cord-010092-uftc8inx 2973 26 . . . cord-010092-uftc8inx 2974 1 Aims aim VBZ cord-010092-uftc8inx 2974 2 : : : cord-010092-uftc8inx 2974 3 To to TO cord-010092-uftc8inx 2974 4 assess assess VB cord-010092-uftc8inx 2974 5 the the DT cord-010092-uftc8inx 2974 6 performance performance NN cord-010092-uftc8inx 2974 7 of of IN cord-010092-uftc8inx 2974 8 the the DT cord-010092-uftc8inx 2974 9 Abbott Abbott NNP cord-010092-uftc8inx 2974 10 Alinity Alinity NNP cord-010092-uftc8inx 2974 11 s s POS cord-010092-uftc8inx 2974 12 CMV CMV NNP cord-010092-uftc8inx 2974 13 IgG igg NN cord-010092-uftc8inx 2974 14 screening screening NN cord-010092-uftc8inx 2974 15 assay assay NN cord-010092-uftc8inx 2974 16 in in IN cord-010092-uftc8inx 2974 17 comparison comparison NN cord-010092-uftc8inx 2974 18 to to IN cord-010092-uftc8inx 2974 19 the the DT cord-010092-uftc8inx 2974 20 CMV CMV NNP cord-010092-uftc8inx 2974 21 Mastazyme Mastazyme NNP cord-010092-uftc8inx 2974 22 EIA EIA NNP cord-010092-uftc8inx 2974 23 ( ( -LRB- cord-010092-uftc8inx 2974 24 Total total JJ cord-010092-uftc8inx 2974 25 AB AB NNP cord-010092-uftc8inx 2974 26 EIA EIA NNP cord-010092-uftc8inx 2974 27 ) ) -RRB- cord-010092-uftc8inx 2974 28 . . . cord-010092-uftc8inx 2975 1 Methods method NNS cord-010092-uftc8inx 2975 2 : : : cord-010092-uftc8inx 2975 3 Diagnostic diagnostic JJ cord-010092-uftc8inx 2975 4 sensitivity sensitivity NN cord-010092-uftc8inx 2975 5 was be VBD cord-010092-uftc8inx 2975 6 determined determine VBN cord-010092-uftc8inx 2975 7 by by IN cord-010092-uftc8inx 2975 8 testing test VBG cord-010092-uftc8inx 2975 9 48 48 CD cord-010092-uftc8inx 2975 10 confirmed confirm VBD cord-010092-uftc8inx 2975 11 CMV CMV NNP cord-010092-uftc8inx 2975 12 IgG igg NN cord-010092-uftc8inx 2975 13 positive positive JJ cord-010092-uftc8inx 2975 14 donors donor NNS cord-010092-uftc8inx 2975 15 from from IN cord-010092-uftc8inx 2975 16 an an DT cord-010092-uftc8inx 2975 17 external external JJ cord-010092-uftc8inx 2975 18 laboratory laboratory NN cord-010092-uftc8inx 2975 19 . . . cord-010092-uftc8inx 2976 1 Sensitivity sensitivity NN cord-010092-uftc8inx 2976 2 was be VBD cord-010092-uftc8inx 2976 3 assessed assess VBN cord-010092-uftc8inx 2976 4 using use VBG cord-010092-uftc8inx 2976 5 three three CD cord-010092-uftc8inx 2976 6 seroconversion seroconversion NN cord-010092-uftc8inx 2976 7 panels panel NNS cord-010092-uftc8inx 2976 8 ( ( -LRB- cord-010092-uftc8inx 2976 9 n n NN cord-010092-uftc8inx 2976 10 = = SYM cord-010092-uftc8inx 2976 11 54 54 CD cord-010092-uftc8inx 2976 12 ) ) -RRB- cord-010092-uftc8inx 2976 13 . . . cord-010092-uftc8inx 2977 1 Analytical analytical JJ cord-010092-uftc8inx 2977 2 sensitivity sensitivity NN cord-010092-uftc8inx 2977 3 was be VBD cord-010092-uftc8inx 2977 4 calculated calculate VBN cord-010092-uftc8inx 2977 5 using use VBG cord-010092-uftc8inx 2977 6 linear linear JJ cord-010092-uftc8inx 2977 7 regression regression NN cord-010092-uftc8inx 2977 8 analysis analysis NN cord-010092-uftc8inx 2977 9 of of IN cord-010092-uftc8inx 2977 10 the the DT cord-010092-uftc8inx 2977 11 WHO WHO NNP cord-010092-uftc8inx 2977 12 first first RB cord-010092-uftc8inx 2977 13 international international JJ cord-010092-uftc8inx 2977 14 standard standard NN cord-010092-uftc8inx 2977 15 for for IN cord-010092-uftc8inx 2977 16 anti anti JJ cord-010092-uftc8inx 2977 17 - - JJ cord-010092-uftc8inx 2977 18 CMV CMV NNP cord-010092-uftc8inx 2977 19 IgG. IgG. NNP cord-010092-uftc8inx 2978 1 Diagnostic diagnostic JJ cord-010092-uftc8inx 2978 2 specificity specificity NN cord-010092-uftc8inx 2978 3 was be VBD cord-010092-uftc8inx 2978 4 determined determine VBN cord-010092-uftc8inx 2978 5 by by IN cord-010092-uftc8inx 2978 6 testing test VBG cord-010092-uftc8inx 2978 7 6127 6127 CD cord-010092-uftc8inx 2978 8 donors donor NNS cord-010092-uftc8inx 2978 9 . . . cord-010092-uftc8inx 2979 1 Further further JJ cord-010092-uftc8inx 2979 2 evaluation evaluation NN cord-010092-uftc8inx 2979 3 of of IN cord-010092-uftc8inx 2979 4 discordant discordant JJ cord-010092-uftc8inx 2979 5 results result NNS cord-010092-uftc8inx 2979 6 was be VBD cord-010092-uftc8inx 2979 7 carried carry VBN cord-010092-uftc8inx 2979 8 out out RP cord-010092-uftc8inx 2979 9 using use VBG cord-010092-uftc8inx 2979 10 the the DT cord-010092-uftc8inx 2979 11 Architect Architect NNP cord-010092-uftc8inx 2979 12 anti anti JJ cord-010092-uftc8inx 2979 13 - - JJ cord-010092-uftc8inx 2979 14 CMV CMV NNP cord-010092-uftc8inx 2979 15 IgG igg NN cord-010092-uftc8inx 2979 16 and and CC cord-010092-uftc8inx 2979 17 IgM IgM NNP cord-010092-uftc8inx 2979 18 assays assays NNP cord-010092-uftc8inx 2979 19 and and CC cord-010092-uftc8inx 2979 20 VIDAS VIDAS NNP cord-010092-uftc8inx 2979 21 anti anti JJ cord-010092-uftc8inx 2979 22 - - JJ cord-010092-uftc8inx 2979 23 CMV CMV NNP cord-010092-uftc8inx 2979 24 IgG igg NN cord-010092-uftc8inx 2979 25 and and CC cord-010092-uftc8inx 2979 26 IgM IgM NNP cord-010092-uftc8inx 2979 27 assays assays NNP cord-010092-uftc8inx 2979 28 . . . cord-010092-uftc8inx 2980 1 Results result NNS cord-010092-uftc8inx 2980 2 : : : cord-010092-uftc8inx 2981 1 The the DT cord-010092-uftc8inx 2981 2 diagnostic diagnostic JJ cord-010092-uftc8inx 2981 3 sensitivity sensitivity NN cord-010092-uftc8inx 2981 4 of of IN cord-010092-uftc8inx 2981 5 the the DT cord-010092-uftc8inx 2981 6 Alinity Alinity NNP cord-010092-uftc8inx 2981 7 s s POS cord-010092-uftc8inx 2981 8 anti anti JJ cord-010092-uftc8inx 2981 9 - - JJ cord-010092-uftc8inx 2981 10 CMV CMV NNP cord-010092-uftc8inx 2981 11 IgG igg NN cord-010092-uftc8inx 2981 12 assay assay NN cord-010092-uftc8inx 2981 13 was be VBD cord-010092-uftc8inx 2981 14 determined determine VBN cord-010092-uftc8inx 2981 15 to to TO cord-010092-uftc8inx 2981 16 be be VB cord-010092-uftc8inx 2981 17 100 100 CD cord-010092-uftc8inx 2981 18 % % NN cord-010092-uftc8inx 2981 19 . . . cord-010092-uftc8inx 2982 1 The the DT cord-010092-uftc8inx 2982 2 seroconversion seroconversion NN cord-010092-uftc8inx 2982 3 sensitivity sensitivity NN cord-010092-uftc8inx 2982 4 reported report VBD cord-010092-uftc8inx 2982 5 42 42 CD cord-010092-uftc8inx 2982 6 out out IN cord-010092-uftc8inx 2982 7 of of IN cord-010092-uftc8inx 2982 8 54 54 CD cord-010092-uftc8inx 2982 9 samples sample NNS cord-010092-uftc8inx 2982 10 reactive reactive JJ cord-010092-uftc8inx 2982 11 . . . cord-010092-uftc8inx 2983 1 The the DT cord-010092-uftc8inx 2983 2 analytical analytical JJ cord-010092-uftc8inx 2983 3 sensitivity sensitivity NN cord-010092-uftc8inx 2983 4 of of IN cord-010092-uftc8inx 2983 5 the the DT cord-010092-uftc8inx 2983 6 Alinity Alinity NNP cord-010092-uftc8inx 2983 7 s s POS cord-010092-uftc8inx 2983 8 CMV CMV NNP cord-010092-uftc8inx 2983 9 IgG igg NN cord-010092-uftc8inx 2983 10 assay assay NN cord-010092-uftc8inx 2983 11 was be VBD cord-010092-uftc8inx 2983 12 determined determine VBN cord-010092-uftc8inx 2983 13 to to TO cord-010092-uftc8inx 2983 14 be be VB cord-010092-uftc8inx 2983 15 1.12 1.12 CD cord-010092-uftc8inx 2983 16 IU IU NNP cord-010092-uftc8inx 2983 17 / / SYM cord-010092-uftc8inx 2983 18 ml ml NN cord-010092-uftc8inx 2983 19 . . . cord-010092-uftc8inx 2984 1 The the DT cord-010092-uftc8inx 2984 2 validation validation NN cord-010092-uftc8inx 2984 3 reported report VBD cord-010092-uftc8inx 2984 4 65 65 CD cord-010092-uftc8inx 2984 5 discordant discordant JJ cord-010092-uftc8inx 2984 6 results result NNS cord-010092-uftc8inx 2984 7 from from IN cord-010092-uftc8inx 2984 8 6127 6127 CD cord-010092-uftc8inx 2984 9 donor donor NN cord-010092-uftc8inx 2984 10 samples sample NNS cord-010092-uftc8inx 2984 11 tested test VBN cord-010092-uftc8inx 2984 12 with with IN cord-010092-uftc8inx 2984 13 both both CC cord-010092-uftc8inx 2984 14 the the DT cord-010092-uftc8inx 2984 15 Alinity Alinity NNP cord-010092-uftc8inx 2984 16 s s POS cord-010092-uftc8inx 2984 17 CMV CMV NNP cord-010092-uftc8inx 2984 18 IgG igg NN cord-010092-uftc8inx 2984 19 assay assay NN cord-010092-uftc8inx 2984 20 and and CC cord-010092-uftc8inx 2984 21 the the DT cord-010092-uftc8inx 2984 22 current current JJ cord-010092-uftc8inx 2984 23 Mastazyme Mastazyme NNP cord-010092-uftc8inx 2984 24 total total JJ cord-010092-uftc8inx 2984 25 assay assay NN cord-010092-uftc8inx 2984 26 . . . cord-010092-uftc8inx 2985 1 60 60 CD cord-010092-uftc8inx 2985 2 discordant discordant JJ cord-010092-uftc8inx 2985 3 results result NNS cord-010092-uftc8inx 2985 4 were be VBD cord-010092-uftc8inx 2985 5 observed observe VBN cord-010092-uftc8inx 2985 6 ( ( -LRB- cord-010092-uftc8inx 2985 7 Alinity Alinity NNP cord-010092-uftc8inx 2985 8 s s POS cord-010092-uftc8inx 2985 9 anti anti JJ cord-010092-uftc8inx 2985 10 - - JJ cord-010092-uftc8inx 2985 11 CMV CMV NNP cord-010092-uftc8inx 2985 12 IgG igg NN cord-010092-uftc8inx 2985 13 positive positive JJ cord-010092-uftc8inx 2985 14 / / SYM cord-010092-uftc8inx 2985 15 Mastazyme Mastazyme NNPS cord-010092-uftc8inx 2985 16 total total VBP cord-010092-uftc8inx 2985 17 negative negative JJ cord-010092-uftc8inx 2985 18 ) ) -RRB- cord-010092-uftc8inx 2985 19 . . . cord-010092-uftc8inx 2986 1 Further further JJ cord-010092-uftc8inx 2986 2 testing testing NN cord-010092-uftc8inx 2986 3 of of IN cord-010092-uftc8inx 2986 4 these these DT cord-010092-uftc8inx 2986 5 samples sample NNS cord-010092-uftc8inx 2986 6 classified classify VBD cord-010092-uftc8inx 2986 7 27 27 CD cord-010092-uftc8inx 2986 8 discordant discordant JJ cord-010092-uftc8inx 2986 9 results result NNS cord-010092-uftc8inx 2986 10 as as IN cord-010092-uftc8inx 2986 11 positive positive JJ cord-010092-uftc8inx 2986 12 , , , cord-010092-uftc8inx 2986 13 12 12 CD cord-010092-uftc8inx 2986 14 as as IN cord-010092-uftc8inx 2986 15 negative negative JJ cord-010092-uftc8inx 2986 16 and and CC cord-010092-uftc8inx 2986 17 21 21 CD cord-010092-uftc8inx 2986 18 as as IN cord-010092-uftc8inx 2986 19 indeterminate indeterminate JJ cord-010092-uftc8inx 2986 20 . . . cord-010092-uftc8inx 2987 1 5 5 CD cord-010092-uftc8inx 2987 2 discordant discordant JJ cord-010092-uftc8inx 2987 3 results result NNS cord-010092-uftc8inx 2987 4 were be VBD cord-010092-uftc8inx 2987 5 observed observe VBN cord-010092-uftc8inx 2987 6 ( ( -LRB- cord-010092-uftc8inx 2988 1 Alinity Alinity NNP cord-010092-uftc8inx 2988 2 s s POS cord-010092-uftc8inx 2988 3 anti anti JJ cord-010092-uftc8inx 2988 4 - - JJ cord-010092-uftc8inx 2988 5 CMV CMV NNP cord-010092-uftc8inx 2988 6 IgG igg NN cord-010092-uftc8inx 2988 7 negative negative JJ cord-010092-uftc8inx 2988 8 / / SYM cord-010092-uftc8inx 2988 9 Mastazyme Mastazyme NNPS cord-010092-uftc8inx 2988 10 total total VBP cord-010092-uftc8inx 2988 11 positive positive JJ cord-010092-uftc8inx 2988 12 ) ) -RRB- cord-010092-uftc8inx 2988 13 . . . cord-010092-uftc8inx 2989 1 Further further RB cord-010092-uftc8inx 2989 2 testing test VBG cord-010092-uftc8inx 2989 3 classified classify VBD cord-010092-uftc8inx 2989 4 these these DT cord-010092-uftc8inx 2989 5 samples sample NNS cord-010092-uftc8inx 2989 6 as as IN cord-010092-uftc8inx 2989 7 negative negative JJ cord-010092-uftc8inx 2989 8 . . . cord-010092-uftc8inx 2990 1 Overall overall RB cord-010092-uftc8inx 2990 2 the the DT cord-010092-uftc8inx 2990 3 diagnostic diagnostic JJ cord-010092-uftc8inx 2990 4 specificity specificity NN cord-010092-uftc8inx 2990 5 was be VBD cord-010092-uftc8inx 2990 6 determined determine VBN cord-010092-uftc8inx 2990 7 to to TO cord-010092-uftc8inx 2990 8 be be VB cord-010092-uftc8inx 2990 9 99.80 99.80 CD cord-010092-uftc8inx 2990 10 % % NN cord-010092-uftc8inx 2990 11 . . . cord-010092-uftc8inx 2991 1 Summary Summary NNP cord-010092-uftc8inx 2991 2 / / SYM cord-010092-uftc8inx 2991 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 2991 4 : : : cord-010092-uftc8inx 2992 1 Both both DT cord-010092-uftc8inx 2992 2 the the DT cord-010092-uftc8inx 2992 3 seroconversion seroconversion NN cord-010092-uftc8inx 2992 4 and and CC cord-010092-uftc8inx 2992 5 analytical analytical JJ cord-010092-uftc8inx 2992 6 sensitivities sensitivity NNS cord-010092-uftc8inx 2992 7 are be VBP cord-010092-uftc8inx 2992 8 comparable comparable JJ cord-010092-uftc8inx 2992 9 between between IN cord-010092-uftc8inx 2992 10 the the DT cord-010092-uftc8inx 2992 11 Alinity Alinity NNP cord-010092-uftc8inx 2992 12 s s POS cord-010092-uftc8inx 2992 13 CMV CMV NNP cord-010092-uftc8inx 2992 14 IgG igg NN cord-010092-uftc8inx 2992 15 assay assay NN cord-010092-uftc8inx 2992 16 , , , cord-010092-uftc8inx 2992 17 the the DT cord-010092-uftc8inx 2992 18 CMV CMV NNP cord-010092-uftc8inx 2992 19 Mastazyme Mastazyme NNP cord-010092-uftc8inx 2992 20 Total Total NNP cord-010092-uftc8inx 2992 21 AB AB NNP cord-010092-uftc8inx 2992 22 assay assay NN cord-010092-uftc8inx 2992 23 , , , cord-010092-uftc8inx 2992 24 the the DT cord-010092-uftc8inx 2992 25 Architect Architect NNP cord-010092-uftc8inx 2992 26 CMV CMV NNP cord-010092-uftc8inx 2992 27 IgG igg NN cord-010092-uftc8inx 2992 28 assay assay NN cord-010092-uftc8inx 2992 29 and and CC cord-010092-uftc8inx 2992 30 the the DT cord-010092-uftc8inx 2992 31 Vidas Vidas NNP cord-010092-uftc8inx 2992 32 IgG igg NN cord-010092-uftc8inx 2992 33 assay assay NN cord-010092-uftc8inx 2992 34 . . . cord-010092-uftc8inx 2993 1 The the DT cord-010092-uftc8inx 2993 2 slight slight JJ cord-010092-uftc8inx 2993 3 variations variation NNS cord-010092-uftc8inx 2993 4 can can MD cord-010092-uftc8inx 2993 5 be be VB cord-010092-uftc8inx 2993 6 attributed attribute VBN cord-010092-uftc8inx 2993 7 to to IN cord-010092-uftc8inx 2993 8 the the DT cord-010092-uftc8inx 2993 9 individual individual JJ cord-010092-uftc8inx 2993 10 assay assay NN cord-010092-uftc8inx 2993 11 cut cut VBN cord-010092-uftc8inx 2993 12 - - HYPH cord-010092-uftc8inx 2993 13 off off RP cord-010092-uftc8inx 2993 14 definitions definition NNS cord-010092-uftc8inx 2993 15 , , , cord-010092-uftc8inx 2993 16 which which WDT cord-010092-uftc8inx 2993 17 can can MD cord-010092-uftc8inx 2993 18 vary vary VB cord-010092-uftc8inx 2993 19 greatly greatly RB cord-010092-uftc8inx 2993 20 between between IN cord-010092-uftc8inx 2993 21 CMV CMV NNP cord-010092-uftc8inx 2993 22 assays assay NNS cord-010092-uftc8inx 2993 23 . . . cord-010092-uftc8inx 2994 1 It -PRON- PRP cord-010092-uftc8inx 2994 2 must must MD cord-010092-uftc8inx 2994 3 be be VB cord-010092-uftc8inx 2994 4 noted note VBN cord-010092-uftc8inx 2994 5 that that IN cord-010092-uftc8inx 2994 6 the the DT cord-010092-uftc8inx 2994 7 determination determination NN cord-010092-uftc8inx 2994 8 of of IN cord-010092-uftc8inx 2994 9 the the DT cord-010092-uftc8inx 2994 10 diagnostic diagnostic JJ cord-010092-uftc8inx 2994 11 specificity specificity NN cord-010092-uftc8inx 2994 12 ( ( -LRB- cord-010092-uftc8inx 2994 13 99.80 99.80 CD cord-010092-uftc8inx 2994 14 % % NN cord-010092-uftc8inx 2994 15 ) ) -RRB- cord-010092-uftc8inx 2994 16 does do VBZ cord-010092-uftc8inx 2994 17 not not RB cord-010092-uftc8inx 2994 18 include include VB cord-010092-uftc8inx 2994 19 indeterminate indeterminate JJ cord-010092-uftc8inx 2994 20 discordant discordant JJ cord-010092-uftc8inx 2994 21 results result NNS cord-010092-uftc8inx 2994 22 . . . cord-010092-uftc8inx 2995 1 Further further JJ cord-010092-uftc8inx 2995 2 testing testing NN cord-010092-uftc8inx 2995 3 will will MD cord-010092-uftc8inx 2995 4 be be VB cord-010092-uftc8inx 2995 5 carried carry VBN cord-010092-uftc8inx 2995 6 out out RP cord-010092-uftc8inx 2995 7 to to TO cord-010092-uftc8inx 2995 8 try try VB cord-010092-uftc8inx 2995 9 to to TO cord-010092-uftc8inx 2995 10 characterize characterize VB cord-010092-uftc8inx 2995 11 all all DT cord-010092-uftc8inx 2995 12 discordant discordant JJ cord-010092-uftc8inx 2995 13 samples sample NNS cord-010092-uftc8inx 2995 14 in in IN cord-010092-uftc8inx 2995 15 collaboration collaboration NN cord-010092-uftc8inx 2995 16 with with IN cord-010092-uftc8inx 2995 17 Abbott Abbott NNP cord-010092-uftc8inx 2995 18 . . . cord-010092-uftc8inx 2996 1 This this DT cord-010092-uftc8inx 2996 2 evaluation evaluation NN cord-010092-uftc8inx 2996 3 did do VBD cord-010092-uftc8inx 2996 4 not not RB cord-010092-uftc8inx 2996 5 identify identify VB cord-010092-uftc8inx 2996 6 any any DT cord-010092-uftc8inx 2996 7 donors donor NNS cord-010092-uftc8inx 2996 8 with with IN cord-010092-uftc8inx 2996 9 isolated isolate VBN cord-010092-uftc8inx 2996 10 confirmed confirm VBN cord-010092-uftc8inx 2996 11 CMV CMV NNP cord-010092-uftc8inx 2996 12 IgM IgM NNP cord-010092-uftc8inx 2996 13 antibodies antibody NNS cord-010092-uftc8inx 2996 14 in in IN cord-010092-uftc8inx 2996 15 a a DT cord-010092-uftc8inx 2996 16 pool pool NN cord-010092-uftc8inx 2996 17 of of IN cord-010092-uftc8inx 2996 18 6127 6127 CD cord-010092-uftc8inx 2996 19 donors donor NNS cord-010092-uftc8inx 2996 20 . . . cord-010092-uftc8inx 2997 1 Based base VBN cord-010092-uftc8inx 2997 2 on on IN cord-010092-uftc8inx 2997 3 this this DT cord-010092-uftc8inx 2997 4 evaluation evaluation NN cord-010092-uftc8inx 2997 5 the the DT cord-010092-uftc8inx 2997 6 Abbott Abbott NNP cord-010092-uftc8inx 2997 7 Alinity Alinity NNP cord-010092-uftc8inx 2997 8 s s POS cord-010092-uftc8inx 2997 9 CMV CMV NNP cord-010092-uftc8inx 2997 10 IgG igg NN cord-010092-uftc8inx 2997 11 assay assay NN cord-010092-uftc8inx 2997 12 is be VBZ cord-010092-uftc8inx 2997 13 a a DT cord-010092-uftc8inx 2997 14 suitable suitable JJ cord-010092-uftc8inx 2997 15 replacement replacement NN cord-010092-uftc8inx 2997 16 to to IN cord-010092-uftc8inx 2997 17 the the DT cord-010092-uftc8inx 2997 18 Mastazyme Mastazyme NNPS cord-010092-uftc8inx 2997 19 total total NN cord-010092-uftc8inx 2997 20 AB AB NNP cord-010092-uftc8inx 2997 21 assay assay NN cord-010092-uftc8inx 2997 22 for for IN cord-010092-uftc8inx 2997 23 blood blood NN cord-010092-uftc8inx 2997 24 donor donor NN cord-010092-uftc8inx 2997 25 screening screening NN cord-010092-uftc8inx 2997 26 . . . cord-010092-uftc8inx 2998 1 Background background NN cord-010092-uftc8inx 2998 2 : : : cord-010092-uftc8inx 2999 1 Africa Africa NNP cord-010092-uftc8inx 2999 2 has have VBZ cord-010092-uftc8inx 2999 3 a a DT cord-010092-uftc8inx 2999 4 unique unique JJ cord-010092-uftc8inx 2999 5 set set NN cord-010092-uftc8inx 2999 6 of of IN cord-010092-uftc8inx 2999 7 challenges challenge NNS cord-010092-uftc8inx 2999 8 regarding regard VBG cord-010092-uftc8inx 2999 9 safe safe JJ cord-010092-uftc8inx 2999 10 blood blood NN cord-010092-uftc8inx 2999 11 transfusion transfusion NN cord-010092-uftc8inx 2999 12 . . . cord-010092-uftc8inx 3000 1 Two two CD cord-010092-uftc8inx 3000 2 of of IN cord-010092-uftc8inx 3000 3 the the DT cord-010092-uftc8inx 3000 4 largest large JJS cord-010092-uftc8inx 3000 5 contributing contributing JJ cord-010092-uftc8inx 3000 6 factors factor NNS cord-010092-uftc8inx 3000 7 are be VBP cord-010092-uftc8inx 3000 8 : : : cord-010092-uftc8inx 3000 9 1 1 LS cord-010092-uftc8inx 3000 10 ) ) -RRB- cord-010092-uftc8inx 3001 1 The the DT cord-010092-uftc8inx 3001 2 most most RBS cord-010092-uftc8inx 3001 3 common common JJ cord-010092-uftc8inx 3001 4 disease disease NN cord-010092-uftc8inx 3001 5 states state NNS cord-010092-uftc8inx 3001 6 in in IN cord-010092-uftc8inx 3001 7 Sub Sub NNP cord-010092-uftc8inx 3001 8 - - HYPH cord-010092-uftc8inx 3001 9 Saharan Saharan NNP cord-010092-uftc8inx 3001 10 Africa Africa NNP cord-010092-uftc8inx 3001 11 ( ( -LRB- cord-010092-uftc8inx 3001 12 SSA SSA NNP cord-010092-uftc8inx 3001 13 ) ) -RRB- cord-010092-uftc8inx 3001 14 require require VB cord-010092-uftc8inx 3001 15 large large JJ cord-010092-uftc8inx 3001 16 amounts amount NNS cord-010092-uftc8inx 3001 17 of of IN cord-010092-uftc8inx 3001 18 blood blood NN cord-010092-uftc8inx 3001 19 as as IN cord-010092-uftc8inx 3001 20 lifesaving lifesave VBG cord-010092-uftc8inx 3001 21 interventions intervention NNS cord-010092-uftc8inx 3001 22 e.g. e.g. IN cord-010092-uftc8inx 3001 23 malaria malaria NN cord-010092-uftc8inx 3001 24 , , , cord-010092-uftc8inx 3001 25 2 2 LS cord-010092-uftc8inx 3001 26 ) ) -RRB- cord-010092-uftc8inx 3001 27 the the DT cord-010092-uftc8inx 3001 28 highest high JJS cord-010092-uftc8inx 3001 29 burden burden NN cord-010092-uftc8inx 3001 30 of of IN cord-010092-uftc8inx 3001 31 infectious infectious JJ cord-010092-uftc8inx 3001 32 diseases disease NNS cord-010092-uftc8inx 3001 33 transmissible transmissible JJ cord-010092-uftc8inx 3001 34 through through IN cord-010092-uftc8inx 3001 35 transfusion transfusion NN cord-010092-uftc8inx 3001 36 ( ( -LRB- cord-010092-uftc8inx 3001 37 Tapko Tapko NNP cord-010092-uftc8inx 3001 38 , , , cord-010092-uftc8inx 3001 39 Toure Toure NNP cord-010092-uftc8inx 3001 40 , , , cord-010092-uftc8inx 3001 41 & & CC cord-010092-uftc8inx 3001 42 Sambo Sambo NNP cord-010092-uftc8inx 3001 43 , , , cord-010092-uftc8inx 3001 44 2014 2014 CD cord-010092-uftc8inx 3001 45 ) ) -RRB- cord-010092-uftc8inx 3001 46 is be VBZ cord-010092-uftc8inx 3001 47 found find VBN cord-010092-uftc8inx 3001 48 in in IN cord-010092-uftc8inx 3001 49 SSA SSA NNP cord-010092-uftc8inx 3001 50 . . . cord-010092-uftc8inx 3002 1 This this DT cord-010092-uftc8inx 3002 2 has have VBZ cord-010092-uftc8inx 3002 3 often often RB cord-010092-uftc8inx 3002 4 led lead VBN cord-010092-uftc8inx 3002 5 to to IN cord-010092-uftc8inx 3002 6 the the DT cord-010092-uftc8inx 3002 7 binary binary JJ cord-010092-uftc8inx 3002 8 donor donor NN cord-010092-uftc8inx 3002 9 base base NN cord-010092-uftc8inx 3002 10 that that WDT cord-010092-uftc8inx 3002 11 exists exist VBZ cord-010092-uftc8inx 3002 12 in in IN cord-010092-uftc8inx 3002 13 SSA SSA NNP cord-010092-uftc8inx 3002 14 , , , cord-010092-uftc8inx 3002 15 consisting consist VBG cord-010092-uftc8inx 3002 16 of of IN cord-010092-uftc8inx 3002 17 Voluntary Voluntary NNP cord-010092-uftc8inx 3002 18 Non non JJ cord-010092-uftc8inx 3002 19 - - JJ cord-010092-uftc8inx 3002 20 remunerated remunerated JJ cord-010092-uftc8inx 3002 21 Blood blood NN cord-010092-uftc8inx 3002 22 donors donor NNS cord-010092-uftc8inx 3002 23 ( ( -LRB- cord-010092-uftc8inx 3002 24 VNBD VNBD NNP cord-010092-uftc8inx 3002 25 ) ) -RRB- cord-010092-uftc8inx 3002 26 and and CC cord-010092-uftc8inx 3002 27 family family NN cord-010092-uftc8inx 3002 28 or or CC cord-010092-uftc8inx 3002 29 replacement replacement NN cord-010092-uftc8inx 3002 30 donors donor NNS cord-010092-uftc8inx 3002 31 ( ( -LRB- cord-010092-uftc8inx 3002 32 FRD FRD NNP cord-010092-uftc8inx 3002 33 ) ) -RRB- cord-010092-uftc8inx 3002 34 as as IN cord-010092-uftc8inx 3002 35 transfusion transfusion NN cord-010092-uftc8inx 3002 36 centres centre NNS cord-010092-uftc8inx 3002 37 are be VBP cord-010092-uftc8inx 3002 38 unable unable JJ cord-010092-uftc8inx 3002 39 to to TO cord-010092-uftc8inx 3002 40 supply supply VB cord-010092-uftc8inx 3002 41 the the DT cord-010092-uftc8inx 3002 42 demand demand NN cord-010092-uftc8inx 3002 43 when when WRB cord-010092-uftc8inx 3002 44 relying rely VBG cord-010092-uftc8inx 3002 45 only only RB cord-010092-uftc8inx 3002 46 on on IN cord-010092-uftc8inx 3002 47 VNBD VNBD NNP cord-010092-uftc8inx 3002 48 . . . cord-010092-uftc8inx 3003 1 Voluntary voluntary JJ cord-010092-uftc8inx 3003 2 non non JJ cord-010092-uftc8inx 3003 3 - - JJ cord-010092-uftc8inx 3003 4 remunerated remunerated JJ cord-010092-uftc8inx 3003 5 donors donor NNS cord-010092-uftc8inx 3003 6 are be VBP cord-010092-uftc8inx 3003 7 the the DT cord-010092-uftc8inx 3003 8 safest safe JJS cord-010092-uftc8inx 3003 9 blood blood NN cord-010092-uftc8inx 3003 10 donors donor NNS cord-010092-uftc8inx 3003 11 as as IN cord-010092-uftc8inx 3003 12 they -PRON- PRP cord-010092-uftc8inx 3003 13 have have VBP cord-010092-uftc8inx 3003 14 no no DT cord-010092-uftc8inx 3003 15 incentive incentive NN cord-010092-uftc8inx 3003 16 ( ( -LRB- cord-010092-uftc8inx 3003 17 other other JJ cord-010092-uftc8inx 3003 18 than than IN cord-010092-uftc8inx 3003 19 altruistic altruistic JJ cord-010092-uftc8inx 3003 20 motives motive NNS cord-010092-uftc8inx 3003 21 ) ) -RRB- cord-010092-uftc8inx 3003 22 and and CC cord-010092-uftc8inx 3003 23 are be VBP cord-010092-uftc8inx 3003 24 not not RB cord-010092-uftc8inx 3003 25 under under IN cord-010092-uftc8inx 3003 26 social social JJ cord-010092-uftc8inx 3003 27 pressure pressure NN cord-010092-uftc8inx 3003 28 to to TO cord-010092-uftc8inx 3003 29 donate donate VB cord-010092-uftc8inx 3003 30 , , , cord-010092-uftc8inx 3003 31 both both DT cord-010092-uftc8inx 3003 32 factors factor NNS cord-010092-uftc8inx 3003 33 that that WDT cord-010092-uftc8inx 3003 34 may may MD cord-010092-uftc8inx 3003 35 induce induce VB cord-010092-uftc8inx 3003 36 individuals individual NNS cord-010092-uftc8inx 3003 37 knowing know VBG cord-010092-uftc8inx 3003 38 or or CC cord-010092-uftc8inx 3003 39 suspecting suspect VBG cord-010092-uftc8inx 3003 40 themselves -PRON- PRP cord-010092-uftc8inx 3003 41 to to TO cord-010092-uftc8inx 3003 42 be be VB cord-010092-uftc8inx 3003 43 infected infect VBN cord-010092-uftc8inx 3003 44 with with IN cord-010092-uftc8inx 3003 45 a a DT cord-010092-uftc8inx 3003 46 blood blood NN cord-010092-uftc8inx 3003 47 - - HYPH cord-010092-uftc8inx 3003 48 borne bear VBN cord-010092-uftc8inx 3003 49 agent agent NN cord-010092-uftc8inx 3003 50 to to TO cord-010092-uftc8inx 3003 51 donate donate VB cord-010092-uftc8inx 3003 52 blood blood NN cord-010092-uftc8inx 3003 53 . . . cord-010092-uftc8inx 3004 1 Nucleic nucleic JJ cord-010092-uftc8inx 3004 2 Acid acid NN cord-010092-uftc8inx 3004 3 Testing Testing NNP cord-010092-uftc8inx 3004 4 ( ( -LRB- cord-010092-uftc8inx 3004 5 NAT NAT NNP cord-010092-uftc8inx 3004 6 ) ) -RRB- cord-010092-uftc8inx 3004 7 in in IN cord-010092-uftc8inx 3004 8 conjunction conjunction NN cord-010092-uftc8inx 3004 9 with with IN cord-010092-uftc8inx 3004 10 serological serological JJ cord-010092-uftc8inx 3004 11 testing testing NN cord-010092-uftc8inx 3004 12 is be VBZ cord-010092-uftc8inx 3004 13 the the DT cord-010092-uftc8inx 3004 14 gold gold NN cord-010092-uftc8inx 3004 15 standard standard NN cord-010092-uftc8inx 3004 16 for for IN cord-010092-uftc8inx 3004 17 testing testing NN cord-010092-uftc8inx 3004 18 , , , cord-010092-uftc8inx 3004 19 however however RB cord-010092-uftc8inx 3004 20 , , , cord-010092-uftc8inx 3004 21 the the DT cord-010092-uftc8inx 3004 22 vast vast JJ cord-010092-uftc8inx 3004 23 distances distance NNS cord-010092-uftc8inx 3004 24 and and CC cord-010092-uftc8inx 3004 25 high high JJ cord-010092-uftc8inx 3004 26 temperatures temperature NNS cord-010092-uftc8inx 3004 27 of of IN cord-010092-uftc8inx 3004 28 Africa Africa NNP cord-010092-uftc8inx 3004 29 makes make VBZ cord-010092-uftc8inx 3004 30 transport transport NN cord-010092-uftc8inx 3004 31 of of IN cord-010092-uftc8inx 3004 32 traditional traditional JJ cord-010092-uftc8inx 3004 33 plasma plasma NN cord-010092-uftc8inx 3004 34 samples sample NNS cord-010092-uftc8inx 3004 35 a a DT cord-010092-uftc8inx 3004 36 logistical logistical JJ cord-010092-uftc8inx 3004 37 challenge challenge NN cord-010092-uftc8inx 3004 38 . . . cord-010092-uftc8inx 3005 1 Many many JJ cord-010092-uftc8inx 3005 2 publications publication NNS cord-010092-uftc8inx 3005 3 evaluating evaluate VBG cord-010092-uftc8inx 3005 4 the the DT cord-010092-uftc8inx 3005 5 stability stability NN cord-010092-uftc8inx 3005 6 , , , cord-010092-uftc8inx 3005 7 suitability suitability NN cord-010092-uftc8inx 3005 8 , , , cord-010092-uftc8inx 3005 9 and and CC cord-010092-uftc8inx 3005 10 ease ease NN cord-010092-uftc8inx 3005 11 of of IN cord-010092-uftc8inx 3005 12 use use NN cord-010092-uftc8inx 3005 13 of of IN cord-010092-uftc8inx 3005 14 dried dry VBN cord-010092-uftc8inx 3005 15 blood blood NN cord-010092-uftc8inx 3005 16 spots spot NNS cord-010092-uftc8inx 3005 17 ( ( -LRB- cord-010092-uftc8inx 3005 18 DBS DBS NNP cord-010092-uftc8inx 3005 19 ) ) -RRB- cord-010092-uftc8inx 3005 20 for for IN cord-010092-uftc8inx 3005 21 NAT NAT NNP cord-010092-uftc8inx 3005 22 have have VBP cord-010092-uftc8inx 3005 23 been be VBN cord-010092-uftc8inx 3005 24 published publish VBN cord-010092-uftc8inx 3005 25 . . . cord-010092-uftc8inx 3006 1 Generally generally RB cord-010092-uftc8inx 3006 2 , , , cord-010092-uftc8inx 3006 3 results result NNS cord-010092-uftc8inx 3006 4 have have VBP cord-010092-uftc8inx 3006 5 been be VBN cord-010092-uftc8inx 3006 6 shown show VBN cord-010092-uftc8inx 3006 7 to to TO cord-010092-uftc8inx 3006 8 be be VB cord-010092-uftc8inx 3006 9 comparable comparable JJ cord-010092-uftc8inx 3006 10 to to IN cord-010092-uftc8inx 3006 11 traditional traditional JJ cord-010092-uftc8inx 3006 12 plasma plasma NN cord-010092-uftc8inx 3006 13 samples sample NNS cord-010092-uftc8inx 3006 14 . . . cord-010092-uftc8inx 3007 1 DBS DBS NNP cord-010092-uftc8inx 3007 2 is be VBZ cord-010092-uftc8inx 3007 3 being be VBG cord-010092-uftc8inx 3007 4 used use VBN cord-010092-uftc8inx 3007 5 successfully successfully RB cord-010092-uftc8inx 3007 6 in in IN cord-010092-uftc8inx 3007 7 the the DT cord-010092-uftc8inx 3007 8 early early JJ cord-010092-uftc8inx 3007 9 infant infant NN cord-010092-uftc8inx 3007 10 diagnosis diagnosis NN cord-010092-uftc8inx 3007 11 ( ( -LRB- cord-010092-uftc8inx 3007 12 EID EID NNP cord-010092-uftc8inx 3007 13 ) ) -RRB- cord-010092-uftc8inx 3007 14 programs program NNS cord-010092-uftc8inx 3007 15 for for IN cord-010092-uftc8inx 3007 16 HIV HIV NNP cord-010092-uftc8inx 3007 17 by by IN cord-010092-uftc8inx 3007 18 means mean NNS cord-010092-uftc8inx 3007 19 of of IN cord-010092-uftc8inx 3007 20 PCR PCR NNP cord-010092-uftc8inx 3007 21 testing testing NN cord-010092-uftc8inx 3007 22 , , , cord-010092-uftc8inx 3007 23 especially especially RB cord-010092-uftc8inx 3007 24 in in IN cord-010092-uftc8inx 3007 25 Africa Africa NNP cord-010092-uftc8inx 3007 26 . . . cord-010092-uftc8inx 3008 1 Aims aim VBZ cord-010092-uftc8inx 3008 2 : : : cord-010092-uftc8inx 3008 3 1 1 LS cord-010092-uftc8inx 3008 4 . . . cord-010092-uftc8inx 3009 1 To to TO cord-010092-uftc8inx 3009 2 demonstrate demonstrate VB cord-010092-uftc8inx 3009 3 that that IN cord-010092-uftc8inx 3009 4 DBS DBS NNP cord-010092-uftc8inx 3009 5 and/or and/or CC cord-010092-uftc8inx 3009 6 dried dry VBD cord-010092-uftc8inx 3009 7 plasma plasma NN cord-010092-uftc8inx 3009 8 spot spot NN cord-010092-uftc8inx 3009 9 ( ( -LRB- cord-010092-uftc8inx 3009 10 DPS dps NN cord-010092-uftc8inx 3009 11 ) ) -RRB- cord-010092-uftc8inx 3009 12 testing testing NN cord-010092-uftc8inx 3009 13 is be VBZ cord-010092-uftc8inx 3009 14 suitable suitable JJ cord-010092-uftc8inx 3009 15 for for IN cord-010092-uftc8inx 3009 16 blood blood NN cord-010092-uftc8inx 3009 17 donor donor NN cord-010092-uftc8inx 3009 18 screening screening NN cord-010092-uftc8inx 3009 19 and and CC cord-010092-uftc8inx 3009 20 can can MD cord-010092-uftc8inx 3009 21 make make VB cord-010092-uftc8inx 3009 22 NAT NAT NNP cord-010092-uftc8inx 3009 23 testing test VBG cord-010092-uftc8inx 3009 24 more more RBR cord-010092-uftc8inx 3009 25 widely widely RB cord-010092-uftc8inx 3009 26 available available JJ cord-010092-uftc8inx 3009 27 in in IN cord-010092-uftc8inx 3009 28 Africa Africa NNP cord-010092-uftc8inx 3009 29 2 2 CD cord-010092-uftc8inx 3009 30 . . . cord-010092-uftc8inx 3010 1 To to TO cord-010092-uftc8inx 3010 2 determine determine VB cord-010092-uftc8inx 3010 3 the the DT cord-010092-uftc8inx 3010 4 diagnostic diagnostic JJ cord-010092-uftc8inx 3010 5 sensitivity sensitivity NN cord-010092-uftc8inx 3010 6 and and CC cord-010092-uftc8inx 3010 7 specificity specificity NN cord-010092-uftc8inx 3010 8 of of IN cord-010092-uftc8inx 3010 9 testing testing NN cord-010092-uftc8inx 3010 10 DPS DPS NNP cord-010092-uftc8inx 3010 11 and and CC cord-010092-uftc8inx 3010 12 DBS DBS NNP cord-010092-uftc8inx 3010 13 samples sample NNS cord-010092-uftc8inx 3010 14 , , , cord-010092-uftc8inx 3010 15 in in IN cord-010092-uftc8inx 3010 16 comparison comparison NN cord-010092-uftc8inx 3010 17 to to IN cord-010092-uftc8inx 3010 18 testing testing NN cord-010092-uftc8inx 3010 19 of of IN cord-010092-uftc8inx 3010 20 plasma plasma NN cord-010092-uftc8inx 3010 21 samples sample NNS cord-010092-uftc8inx 3010 22 . . . cord-010092-uftc8inx 3011 1 Methods method NNS cord-010092-uftc8inx 3011 2 : : : cord-010092-uftc8inx 3011 3 900 900 CD cord-010092-uftc8inx 3011 4 negative negative JJ cord-010092-uftc8inx 3011 5 new new JJ cord-010092-uftc8inx 3011 6 donor donor NN cord-010092-uftc8inx 3011 7 samples sample NNS cord-010092-uftc8inx 3011 8 and and CC cord-010092-uftc8inx 3011 9 100 100 CD cord-010092-uftc8inx 3011 10 confirmed confirm VBD cord-010092-uftc8inx 3011 11 positive positive JJ cord-010092-uftc8inx 3011 12 donor donor NN cord-010092-uftc8inx 3011 13 samples sample NNS cord-010092-uftc8inx 3011 14 , , , cord-010092-uftc8inx 3011 15 as as IN cord-010092-uftc8inx 3011 16 defined define VBN cord-010092-uftc8inx 3011 17 by by IN cord-010092-uftc8inx 3011 18 routine routine JJ cord-010092-uftc8inx 3011 19 blood blood NN cord-010092-uftc8inx 3011 20 safety safety NN cord-010092-uftc8inx 3011 21 screening screening NN cord-010092-uftc8inx 3011 22 done do VBN cord-010092-uftc8inx 3011 23 at at IN cord-010092-uftc8inx 3011 24 Western Western NNP cord-010092-uftc8inx 3011 25 Cape Cape NNP cord-010092-uftc8inx 3011 26 Blood Blood NNP cord-010092-uftc8inx 3011 27 Service Service NNP cord-010092-uftc8inx 3011 28 , , , cord-010092-uftc8inx 3011 29 were be VBD cord-010092-uftc8inx 3011 30 screened screen VBN cord-010092-uftc8inx 3011 31 using use VBG cord-010092-uftc8inx 3011 32 a a DT cord-010092-uftc8inx 3011 33 dried dry VBN cord-010092-uftc8inx 3011 34 blood blood NN cord-010092-uftc8inx 3011 35 spot spot NN cord-010092-uftc8inx 3011 36 kit kit NN cord-010092-uftc8inx 3011 37 . . . cord-010092-uftc8inx 3012 1 After after IN cord-010092-uftc8inx 3012 2 routine routine JJ cord-010092-uftc8inx 3012 3 testing testing NN cord-010092-uftc8inx 3012 4 was be VBD cord-010092-uftc8inx 3012 5 completed complete VBN cord-010092-uftc8inx 3012 6 , , , cord-010092-uftc8inx 3012 7 one one CD cord-010092-uftc8inx 3012 8 DBS dbs NN cord-010092-uftc8inx 3012 9 sample sample NN cord-010092-uftc8inx 3012 10 and and CC cord-010092-uftc8inx 3012 11 one one CD cord-010092-uftc8inx 3012 12 DPS dps NN cord-010092-uftc8inx 3012 13 sample sample NN cord-010092-uftc8inx 3012 14 for for IN cord-010092-uftc8inx 3012 15 each each DT cord-010092-uftc8inx 3012 16 blood blood NN cord-010092-uftc8inx 3012 17 donor donor NN cord-010092-uftc8inx 3012 18 were be VBD cord-010092-uftc8inx 3012 19 prepared prepare VBN cord-010092-uftc8inx 3012 20 and and CC cord-010092-uftc8inx 3012 21 analysed analyse VBN cord-010092-uftc8inx 3012 22 with with IN cord-010092-uftc8inx 3012 23 the the DT cord-010092-uftc8inx 3012 24 Ultrio Ultrio NNP cord-010092-uftc8inx 3012 25 Elite Elite NNP cord-010092-uftc8inx 3012 26 Assay Assay NNP cord-010092-uftc8inx 3012 27 on on IN cord-010092-uftc8inx 3012 28 the the DT cord-010092-uftc8inx 3012 29 Panther Panther NNP cord-010092-uftc8inx 3012 30 analyser analyser NN cord-010092-uftc8inx 3012 31 . . . cord-010092-uftc8inx 3013 1 Summary Summary NNP cord-010092-uftc8inx 3013 2 / / SYM cord-010092-uftc8inx 3013 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 3013 4 : : : cord-010092-uftc8inx 3014 1 DBS DBS NNP cord-010092-uftc8inx 3014 2 / / SYM cord-010092-uftc8inx 3014 3 DPS DPS NNP cord-010092-uftc8inx 3014 4 can can MD cord-010092-uftc8inx 3014 5 be be VB cord-010092-uftc8inx 3014 6 used use VBN cord-010092-uftc8inx 3014 7 as as IN cord-010092-uftc8inx 3014 8 a a DT cord-010092-uftc8inx 3014 9 sample sample NN cord-010092-uftc8inx 3014 10 for for IN cord-010092-uftc8inx 3014 11 screening screen VBG cord-010092-uftc8inx 3014 12 blood blood NN cord-010092-uftc8inx 3014 13 donors donor NNS cord-010092-uftc8inx 3014 14 as as IN cord-010092-uftc8inx 3014 15 the the DT cord-010092-uftc8inx 3014 16 invalid invalid JJ cord-010092-uftc8inx 3014 17 rate rate NN cord-010092-uftc8inx 3014 18 was be VBD cord-010092-uftc8inx 3014 19 0.56 0.56 CD cord-010092-uftc8inx 3014 20 % % NN cord-010092-uftc8inx 3014 21 , , , cord-010092-uftc8inx 3014 22 and and CC cord-010092-uftc8inx 3014 23 only only RB cord-010092-uftc8inx 3014 24 found find VBN cord-010092-uftc8inx 3014 25 on on IN cord-010092-uftc8inx 3014 26 DBS dbs NN cord-010092-uftc8inx 3014 27 samples sample NNS cord-010092-uftc8inx 3014 28 . . . cord-010092-uftc8inx 3015 1 Logistically Logistically NNP cord-010092-uftc8inx 3015 2 DBS DBS NNP cord-010092-uftc8inx 3015 3 / / SYM cord-010092-uftc8inx 3015 4 DPS DPS NNP cord-010092-uftc8inx 3015 5 is be VBZ cord-010092-uftc8inx 3015 6 well well RB cord-010092-uftc8inx 3015 7 suited suited JJ cord-010092-uftc8inx 3015 8 for for IN cord-010092-uftc8inx 3015 9 the the DT cord-010092-uftc8inx 3015 10 resource resource NN cord-010092-uftc8inx 3015 11 - - HYPH cord-010092-uftc8inx 3015 12 poor poor JJ cord-010092-uftc8inx 3015 13 countries country NNS cord-010092-uftc8inx 3015 14 as as IN cord-010092-uftc8inx 3015 15 samples sample NNS cord-010092-uftc8inx 3015 16 are be VBP cord-010092-uftc8inx 3015 17 : : : cord-010092-uftc8inx 3016 1 -Easy -easy NN cord-010092-uftc8inx 3016 2 to to TO cord-010092-uftc8inx 3016 3 obtain obtain VB cord-010092-uftc8inx 3016 4 ( ( -LRB- cord-010092-uftc8inx 3016 5 fingerpick fingerpick NN cord-010092-uftc8inx 3016 6 samples sample NNS cord-010092-uftc8inx 3016 7 could could MD cord-010092-uftc8inx 3016 8 be be VB cord-010092-uftc8inx 3016 9 used use VBN cord-010092-uftc8inx 3016 10 . . . cord-010092-uftc8inx 3016 11 ) ) -RRB- cord-010092-uftc8inx 3017 1 -Transport -Transport NNP cord-010092-uftc8inx 3017 2 is be VBZ cord-010092-uftc8inx 3017 3 simplified simplify VBN cord-010092-uftc8inx 3017 4 as as IN cord-010092-uftc8inx 3017 5 samples sample NNS cord-010092-uftc8inx 3017 6 will will MD cord-010092-uftc8inx 3017 7 not not RB cord-010092-uftc8inx 3017 8 leak leak VB cord-010092-uftc8inx 3017 9 or or CC cord-010092-uftc8inx 3017 10 haemolyse haemolyse NN cord-010092-uftc8inx 3017 11 due due IN cord-010092-uftc8inx 3017 12 to to IN cord-010092-uftc8inx 3017 13 high high JJ cord-010092-uftc8inx 3017 14 temperatures temperature NNS cord-010092-uftc8inx 3017 15 . . . cord-010092-uftc8inx 3018 1 -Samples -sample NNS cord-010092-uftc8inx 3018 2 can can MD cord-010092-uftc8inx 3018 3 be be VB cord-010092-uftc8inx 3018 4 stored store VBN cord-010092-uftc8inx 3018 5 at at IN cord-010092-uftc8inx 3018 6 room room NN cord-010092-uftc8inx 3018 7 temperature temperature NN cord-010092-uftc8inx 3018 8 DBS DBS NNP cord-010092-uftc8inx 3018 9 / / SYM cord-010092-uftc8inx 3018 10 DPS dps NN cord-010092-uftc8inx 3019 1 demonstrated demonstrate VBD cord-010092-uftc8inx 3019 2 acceptable acceptable JJ cord-010092-uftc8inx 3019 3 specificity specificity NN cord-010092-uftc8inx 3019 4 . . . cord-010092-uftc8inx 3020 1 The the DT cord-010092-uftc8inx 3020 2 Ultrio Ultrio NNP cord-010092-uftc8inx 3020 3 Elite Elite NNP cord-010092-uftc8inx 3020 4 performed perform VBD cord-010092-uftc8inx 3020 5 well well RB cord-010092-uftc8inx 3020 6 with with IN cord-010092-uftc8inx 3020 7 regards regard NNS cord-010092-uftc8inx 3020 8 to to IN cord-010092-uftc8inx 3020 9 HIV HIV NNP cord-010092-uftc8inx 3020 10 and and CC cord-010092-uftc8inx 3020 11 HCV HCV NNP cord-010092-uftc8inx 3020 12 sensitivity sensitivity NN cord-010092-uftc8inx 3020 13 . . . cord-010092-uftc8inx 3021 1 Sensitivity sensitivity NN cord-010092-uftc8inx 3021 2 with with IN cord-010092-uftc8inx 3021 3 regard regard NN cord-010092-uftc8inx 3021 4 to to IN cord-010092-uftc8inx 3021 5 HBV HBV NNP cord-010092-uftc8inx 3021 6 was be VBD cord-010092-uftc8inx 3021 7 not not RB cord-010092-uftc8inx 3021 8 as as RB cord-010092-uftc8inx 3021 9 high high JJ cord-010092-uftc8inx 3021 10 but but CC cord-010092-uftc8inx 3021 11 this this DT cord-010092-uftc8inx 3021 12 could could MD cord-010092-uftc8inx 3021 13 be be VB cord-010092-uftc8inx 3021 14 due due JJ cord-010092-uftc8inx 3021 15 to to IN cord-010092-uftc8inx 3021 16 very very RB cord-010092-uftc8inx 3021 17 low low JJ cord-010092-uftc8inx 3021 18 and and CC cord-010092-uftc8inx 3021 19 erratic erratic JJ cord-010092-uftc8inx 3021 20 viral viral JJ cord-010092-uftc8inx 3021 21 loads load NNS cord-010092-uftc8inx 3021 22 . . . cord-010092-uftc8inx 3022 1 Background background NN cord-010092-uftc8inx 3022 2 : : : cord-010092-uftc8inx 3023 1 Sanquin Sanquin NNP cord-010092-uftc8inx 3023 2 Blood Blood NNP cord-010092-uftc8inx 3023 3 Supply Supply NNP cord-010092-uftc8inx 3023 4 is be VBZ cord-010092-uftc8inx 3023 5 responsible responsible JJ cord-010092-uftc8inx 3023 6 for for IN cord-010092-uftc8inx 3023 7 the the DT cord-010092-uftc8inx 3023 8 blood blood NN cord-010092-uftc8inx 3023 9 transfusion transfusion NN cord-010092-uftc8inx 3023 10 services service NNS cord-010092-uftc8inx 3023 11 in in IN cord-010092-uftc8inx 3023 12 The the DT cord-010092-uftc8inx 3023 13 Netherlands Netherlands NNP cord-010092-uftc8inx 3023 14 . . . cord-010092-uftc8inx 3024 1 At at IN cord-010092-uftc8inx 3024 2 the the DT cord-010092-uftc8inx 3024 3 National National NNP cord-010092-uftc8inx 3024 4 Screening Screening NNP cord-010092-uftc8inx 3024 5 laboratory laboratory NN cord-010092-uftc8inx 3024 6 Sanquin Sanquin NNP cord-010092-uftc8inx 3024 7 ( ( -LRB- cord-010092-uftc8inx 3024 8 NSS NSS NNP cord-010092-uftc8inx 3024 9 ) ) -RRB- cord-010092-uftc8inx 3024 10 annually annually RB cord-010092-uftc8inx 3024 11 more more JJR cord-010092-uftc8inx 3024 12 than than IN cord-010092-uftc8inx 3024 13 750.000 750.000 CD cord-010092-uftc8inx 3024 14 blood blood NN cord-010092-uftc8inx 3024 15 and and CC cord-010092-uftc8inx 3024 16 plasma plasma NN cord-010092-uftc8inx 3024 17 donations donation NNS cord-010092-uftc8inx 3024 18 are be VBP cord-010092-uftc8inx 3024 19 tested test VBN cord-010092-uftc8inx 3024 20 , , , cord-010092-uftc8inx 3024 21 on on IN cord-010092-uftc8inx 3024 22 average average JJ cord-010092-uftc8inx 3024 23 3.000 3.000 CD cord-010092-uftc8inx 3024 24 samples sample NNS cord-010092-uftc8inx 3024 25 per per IN cord-010092-uftc8inx 3024 26 day day NN cord-010092-uftc8inx 3024 27 . . . cord-010092-uftc8inx 3025 1 For for IN cord-010092-uftc8inx 3025 2 more more JJR cord-010092-uftc8inx 3025 3 than than IN cord-010092-uftc8inx 3025 4 10 10 CD cord-010092-uftc8inx 3025 5 years year NNS cord-010092-uftc8inx 3025 6 , , , cord-010092-uftc8inx 3025 7 infection infection NN cord-010092-uftc8inx 3025 8 serology serology NN cord-010092-uftc8inx 3025 9 testing testing NN cord-010092-uftc8inx 3025 10 was be VBD cord-010092-uftc8inx 3025 11 performed perform VBN cord-010092-uftc8inx 3025 12 using use VBG cord-010092-uftc8inx 3025 13 the the DT cord-010092-uftc8inx 3025 14 PRISM PRISM NNP cord-010092-uftc8inx 3025 15 ( ( -LRB- cord-010092-uftc8inx 3025 16 Abbott Abbott NNP cord-010092-uftc8inx 3025 17 Diagnostics Diagnostics NNP cord-010092-uftc8inx 3025 18 ) ) -RRB- cord-010092-uftc8inx 3025 19 , , , cord-010092-uftc8inx 3025 20 but but CC cord-010092-uftc8inx 3025 21 since since IN cord-010092-uftc8inx 3025 22 mid mid NN cord-010092-uftc8inx 3025 23 of of IN cord-010092-uftc8inx 3025 24 July July NNP cord-010092-uftc8inx 3025 25 2018 2018 CD cord-010092-uftc8inx 3025 26 , , , cord-010092-uftc8inx 3025 27 serological serological JJ cord-010092-uftc8inx 3025 28 testing testing NN cord-010092-uftc8inx 3025 29 for for IN cord-010092-uftc8inx 3025 30 the the DT cord-010092-uftc8inx 3025 31 HBsAg hbsag XX cord-010092-uftc8inx 3025 32 , , , cord-010092-uftc8inx 3025 33 HIV HIV NNP cord-010092-uftc8inx 3025 34 Ag Ag NNP cord-010092-uftc8inx 3025 35 / / SYM cord-010092-uftc8inx 3025 36 Ab Ab NNP cord-010092-uftc8inx 3025 37 , , , cord-010092-uftc8inx 3025 38 Anti Anti NNP cord-010092-uftc8inx 3025 39 - - NNP cord-010092-uftc8inx 3025 40 HCV HCV NNP cord-010092-uftc8inx 3025 41 and and CC cord-010092-uftc8inx 3025 42 Anti Anti NNP cord-010092-uftc8inx 3025 43 - - NNP cord-010092-uftc8inx 3025 44 HBc HBc NNP cord-010092-uftc8inx 3025 45 is be VBZ cord-010092-uftc8inx 3025 46 done do VBN cord-010092-uftc8inx 3025 47 with with IN cord-010092-uftc8inx 3025 48 Abbott Abbott NNP cord-010092-uftc8inx 3025 49 's 's POS cord-010092-uftc8inx 3025 50 Alinity Alinity NNP cord-010092-uftc8inx 3025 51 s s POS cord-010092-uftc8inx 3025 52 system system NN cord-010092-uftc8inx 3025 53 . . . cord-010092-uftc8inx 3026 1 Aims aim VBZ cord-010092-uftc8inx 3026 2 : : : cord-010092-uftc8inx 3026 3 To to TO cord-010092-uftc8inx 3026 4 compare compare VB cord-010092-uftc8inx 3026 5 the the DT cord-010092-uftc8inx 3026 6 numbers number NNS cord-010092-uftc8inx 3026 7 of of IN cord-010092-uftc8inx 3026 8 initially initially RB cord-010092-uftc8inx 3026 9 and and CC cord-010092-uftc8inx 3026 10 repeatedly repeatedly RB cord-010092-uftc8inx 3026 11 reactive reactive JJ cord-010092-uftc8inx 3026 12 results result NNS cord-010092-uftc8inx 3026 13 of of IN cord-010092-uftc8inx 3026 14 whole whole JJ cord-010092-uftc8inx 3026 15 blood blood NN cord-010092-uftc8inx 3026 16 and and CC cord-010092-uftc8inx 3026 17 plasma plasma NN cord-010092-uftc8inx 3026 18 donation donation NN cord-010092-uftc8inx 3026 19 samples sample NNS cord-010092-uftc8inx 3026 20 and and CC cord-010092-uftc8inx 3026 21 the the DT cord-010092-uftc8inx 3026 22 rate rate NN cord-010092-uftc8inx 3026 23 of of IN cord-010092-uftc8inx 3026 24 non non JJ cord-010092-uftc8inx 3026 25 - - JJ cord-010092-uftc8inx 3026 26 specific specific JJ cord-010092-uftc8inx 3026 27 results result NNS cord-010092-uftc8inx 3026 28 leading lead VBG cord-010092-uftc8inx 3026 29 to to IN cord-010092-uftc8inx 3026 30 deferral deferral NN cord-010092-uftc8inx 3026 31 of of IN cord-010092-uftc8inx 3026 32 donations donation NNS cord-010092-uftc8inx 3026 33 and and CC cord-010092-uftc8inx 3026 34 donors donor NNS cord-010092-uftc8inx 3026 35 for for IN cord-010092-uftc8inx 3026 36 PRISM PRISM NNP cord-010092-uftc8inx 3026 37 and and CC cord-010092-uftc8inx 3026 38 Alinity Alinity NNP cord-010092-uftc8inx 3026 39 s s POS cord-010092-uftc8inx 3026 40 assays assay NNS cord-010092-uftc8inx 3026 41 using use VBG cord-010092-uftc8inx 3026 42 data datum NNS cord-010092-uftc8inx 3026 43 from from IN cord-010092-uftc8inx 3026 44 6 6 CD cord-010092-uftc8inx 3026 45 months month NNS cord-010092-uftc8inx 3026 46 before before RB cord-010092-uftc8inx 3026 47 and and CC cord-010092-uftc8inx 3026 48 5 5 CD cord-010092-uftc8inx 3026 49 months month NNS cord-010092-uftc8inx 3026 50 after after IN cord-010092-uftc8inx 3026 51 implementation implementation NN cord-010092-uftc8inx 3026 52 of of IN cord-010092-uftc8inx 3026 53 the the DT cord-010092-uftc8inx 3026 54 Alinity Alinity NNP cord-010092-uftc8inx 3026 55 s s POS cord-010092-uftc8inx 3026 56 systems system NNS cord-010092-uftc8inx 3026 57 at at IN cord-010092-uftc8inx 3026 58 NSS NSS NNP cord-010092-uftc8inx 3026 59 . . . cord-010092-uftc8inx 3027 1 Methods method NNS cord-010092-uftc8inx 3027 2 : : : cord-010092-uftc8inx 3028 1 Initial initial JJ cord-010092-uftc8inx 3028 2 and and CC cord-010092-uftc8inx 3028 3 repeat repeat VB cord-010092-uftc8inx 3028 4 reactive reactive JJ cord-010092-uftc8inx 3028 5 rate rate NN cord-010092-uftc8inx 3028 6 of of IN cord-010092-uftc8inx 3028 7 the the DT cord-010092-uftc8inx 3028 8 assays assay NNS cord-010092-uftc8inx 3028 9 run run VBN cord-010092-uftc8inx 3028 10 by by IN cord-010092-uftc8inx 3028 11 either either DT cord-010092-uftc8inx 3028 12 PRISM PRISM NNP cord-010092-uftc8inx 3028 13 ( ( -LRB- cord-010092-uftc8inx 3028 14 HBsAg hbsag ADD cord-010092-uftc8inx 3028 15 , , , cord-010092-uftc8inx 3028 16 HIV HIV NNP cord-010092-uftc8inx 3028 17 O O NNP cord-010092-uftc8inx 3028 18 Plus Plus NNP cord-010092-uftc8inx 3028 19 , , , cord-010092-uftc8inx 3028 20 HCV HCV NNP cord-010092-uftc8inx 3028 21 ) ) -RRB- cord-010092-uftc8inx 3028 22 or or CC cord-010092-uftc8inx 3028 23 Alinity Alinity NNP cord-010092-uftc8inx 3028 24 s s NNP cord-010092-uftc8inx 3028 25 ( ( -LRB- cord-010092-uftc8inx 3028 26 HBsAg hbsag ADD cord-010092-uftc8inx 3028 27 , , , cord-010092-uftc8inx 3028 28 HIV HIV NNP cord-010092-uftc8inx 3028 29 Ag Ag NNP cord-010092-uftc8inx 3028 30 / / SYM cord-010092-uftc8inx 3028 31 Ab Ab NNP cord-010092-uftc8inx 3028 32 Combo Combo NNP cord-010092-uftc8inx 3028 33 , , , cord-010092-uftc8inx 3028 34 Anti Anti NNP cord-010092-uftc8inx 3028 35 - - NNP cord-010092-uftc8inx 3028 36 HCV HCV NNP cord-010092-uftc8inx 3028 37 , , , cord-010092-uftc8inx 3028 38 ) ) -RRB- cord-010092-uftc8inx 3028 39 were be VBD cord-010092-uftc8inx 3028 40 calculated calculate VBN cord-010092-uftc8inx 3028 41 for for IN cord-010092-uftc8inx 3028 42 January January NNP cord-010092-uftc8inx 3028 43 to to IN cord-010092-uftc8inx 3028 44 June June NNP cord-010092-uftc8inx 3028 45 2018 2018 CD cord-010092-uftc8inx 3029 1 ( ( -LRB- cord-010092-uftc8inx 3029 2 PRISM PRISM NNP cord-010092-uftc8inx 3029 3 ) ) -RRB- cord-010092-uftc8inx 3029 4 and and CC cord-010092-uftc8inx 3029 5 August August NNP cord-010092-uftc8inx 3029 6 to to IN cord-010092-uftc8inx 3029 7 December December NNP cord-010092-uftc8inx 3029 8 2018 2018 CD cord-010092-uftc8inx 3030 1 ( ( -LRB- cord-010092-uftc8inx 3030 2 Alinity Alinity NNP cord-010092-uftc8inx 3030 3 s s POS cord-010092-uftc8inx 3030 4 ) ) -RRB- cord-010092-uftc8inx 3030 5 . . . cord-010092-uftc8inx 3031 1 Due due IN cord-010092-uftc8inx 3031 2 to to IN cord-010092-uftc8inx 3031 3 the the DT cord-010092-uftc8inx 3031 4 lack lack NN cord-010092-uftc8inx 3031 5 of of IN cord-010092-uftc8inx 3031 6 a a DT cord-010092-uftc8inx 3031 7 true true JJ cord-010092-uftc8inx 3031 8 confirmatory confirmatory JJ cord-010092-uftc8inx 3031 9 method method NN cord-010092-uftc8inx 3031 10 for for IN cord-010092-uftc8inx 3031 11 Anti Anti NNP cord-010092-uftc8inx 3031 12 - - NNP cord-010092-uftc8inx 3031 13 HBc HBc NNP cord-010092-uftc8inx 3031 14 , , , cord-010092-uftc8inx 3031 15 we -PRON- PRP cord-010092-uftc8inx 3031 16 only only RB cord-010092-uftc8inx 3031 17 compared compare VBD cord-010092-uftc8inx 3031 18 the the DT cord-010092-uftc8inx 3031 19 rate rate NN cord-010092-uftc8inx 3031 20 of of IN cord-010092-uftc8inx 3031 21 repeatedly repeatedly RB cord-010092-uftc8inx 3031 22 reactive reactive JJ cord-010092-uftc8inx 3031 23 results result NNS cord-010092-uftc8inx 3031 24 for for IN cord-010092-uftc8inx 3031 25 PRISM PRISM NNP cord-010092-uftc8inx 3031 26 HBc HBc NNP cord-010092-uftc8inx 3031 27 and and CC cord-010092-uftc8inx 3031 28 Alinity Alinity NNP cord-010092-uftc8inx 3031 29 s s POS cord-010092-uftc8inx 3031 30 Anti Anti NNP cord-010092-uftc8inx 3031 31 - - NNP cord-010092-uftc8inx 3031 32 HBc HBc NNP cord-010092-uftc8inx 3031 33 . . . cord-010092-uftc8inx 3032 1 Results result NNS cord-010092-uftc8inx 3032 2 : : : cord-010092-uftc8inx 3033 1 The the DT cord-010092-uftc8inx 3033 2 rate rate NN cord-010092-uftc8inx 3033 3 of of IN cord-010092-uftc8inx 3033 4 repeat repeat NN cord-010092-uftc8inx 3033 5 reactive reactive JJ cord-010092-uftc8inx 3033 6 results result NNS cord-010092-uftc8inx 3033 7 for for IN cord-010092-uftc8inx 3033 8 PRISM prism NN cord-010092-uftc8inx 3033 9 ( ( -LRB- cord-010092-uftc8inx 3033 10 P p NN cord-010092-uftc8inx 3033 11 ) ) -RRB- cord-010092-uftc8inx 3033 12 and and CC cord-010092-uftc8inx 3033 13 Alinity Alinity NNP cord-010092-uftc8inx 3033 14 s s POS cord-010092-uftc8inx 3033 15 ( ( -LRB- cord-010092-uftc8inx 3033 16 A a NN cord-010092-uftc8inx 3033 17 ) ) -RRB- cord-010092-uftc8inx 3033 18 assays assay NNS cord-010092-uftc8inx 3033 19 were be VBD cord-010092-uftc8inx 3033 20 as as IN cord-010092-uftc8inx 3033 21 follows follow VBZ cord-010092-uftc8inx 3033 22 : : : cord-010092-uftc8inx 3034 1 1 1 LS cord-010092-uftc8inx 3034 2 ) ) -RRB- cord-010092-uftc8inx 3034 3 HBsAg hbsag ADD cord-010092-uftc8inx 3035 1 P p NN cord-010092-uftc8inx 3035 2 0.01 0.01 CD cord-010092-uftc8inx 3035 3 % % NN cord-010092-uftc8inx 3035 4 ( ( -LRB- cord-010092-uftc8inx 3035 5 42/390.736 42/390.736 CD cord-010092-uftc8inx 3035 6 ) ) -RRB- cord-010092-uftc8inx 3036 1 versus versus IN cord-010092-uftc8inx 3036 2 A a DT cord-010092-uftc8inx 3036 3 0.03 0.03 CD cord-010092-uftc8inx 3036 4 % % NN cord-010092-uftc8inx 3036 5 ( ( -LRB- cord-010092-uftc8inx 3036 6 87/322.394 87/322.394 CD cord-010092-uftc8inx 3036 7 ) ) -RRB- cord-010092-uftc8inx 3036 8 ; ; : cord-010092-uftc8inx 3036 9 2 2 LS cord-010092-uftc8inx 3036 10 ) ) -RRB- cord-010092-uftc8inx 3036 11 HIV HIV NNP cord-010092-uftc8inx 3036 12 P P NNP cord-010092-uftc8inx 3036 13 0.07 0.07 CD cord-010092-uftc8inx 3036 14 % % NN cord-010092-uftc8inx 3036 15 ( ( -LRB- cord-010092-uftc8inx 3036 16 262/390.735 262/390.735 CD cord-010092-uftc8inx 3036 17 ) ) -RRB- cord-010092-uftc8inx 3036 18 versus versus IN cord-010092-uftc8inx 3036 19 A a DT cord-010092-uftc8inx 3036 20 0.06 0.06 CD cord-010092-uftc8inx 3036 21 % % NN cord-010092-uftc8inx 3036 22 ( ( -LRB- cord-010092-uftc8inx 3036 23 201/322.470 201/322.470 CD cord-010092-uftc8inx 3036 24 ) ) -RRB- cord-010092-uftc8inx 3036 25 ; ; : cord-010092-uftc8inx 3036 26 3 3 LS cord-010092-uftc8inx 3036 27 ) ) -RRB- cord-010092-uftc8inx 3036 28 Anti anti JJ cord-010092-uftc8inx 3036 29 - - JJ cord-010092-uftc8inx 3036 30 HCV HCV NNP cord-010092-uftc8inx 3036 31 P p NN cord-010092-uftc8inx 3036 32 0.11 0.11 CD cord-010092-uftc8inx 3036 33 % % NN cord-010092-uftc8inx 3036 34 ( ( -LRB- cord-010092-uftc8inx 3036 35 427/390.737 427/390.737 CD cord-010092-uftc8inx 3036 36 ) ) -RRB- cord-010092-uftc8inx 3036 37 versus versus IN cord-010092-uftc8inx 3036 38 A a DT cord-010092-uftc8inx 3036 39 0.03 0.03 CD cord-010092-uftc8inx 3036 40 % % NN cord-010092-uftc8inx 3036 41 ( ( -LRB- cord-010092-uftc8inx 3036 42 109/322.476 109/322.476 CD cord-010092-uftc8inx 3036 43 ) ) -RRB- cord-010092-uftc8inx 3036 44 . . . cord-010092-uftc8inx 3037 1 The the DT cord-010092-uftc8inx 3037 2 rate rate NN cord-010092-uftc8inx 3037 3 of of IN cord-010092-uftc8inx 3037 4 anti anti JJ cord-010092-uftc8inx 3037 5 - - JJ cord-010092-uftc8inx 3037 6 HBc hbc JJ cord-010092-uftc8inx 3037 7 reactive reactive JJ cord-010092-uftc8inx 3037 8 samples sample NNS cord-010092-uftc8inx 3037 9 was be VBD cord-010092-uftc8inx 3037 10 not not RB cord-010092-uftc8inx 3037 11 significantly significantly RB cord-010092-uftc8inx 3037 12 different different JJ cord-010092-uftc8inx 3037 13 between between IN cord-010092-uftc8inx 3037 14 PRISM PRISM NNP cord-010092-uftc8inx 3037 15 ( ( -LRB- cord-010092-uftc8inx 3037 16 0.39 0.39 CD cord-010092-uftc8inx 3037 17 % % NN cord-010092-uftc8inx 3037 18 ) ) -RRB- cord-010092-uftc8inx 3037 19 and and CC cord-010092-uftc8inx 3037 20 Alinity Alinity NNP cord-010092-uftc8inx 3037 21 s s POS cord-010092-uftc8inx 3037 22 ( ( -LRB- cord-010092-uftc8inx 3037 23 0.42 0.42 CD cord-010092-uftc8inx 3037 24 % % NN cord-010092-uftc8inx 3037 25 ) ) -RRB- cord-010092-uftc8inx 3037 26 . . . cord-010092-uftc8inx 3038 1 Over over IN cord-010092-uftc8inx 3038 2 the the DT cord-010092-uftc8inx 3038 3 study study NN cord-010092-uftc8inx 3038 4 period period NN cord-010092-uftc8inx 3038 5 , , , cord-010092-uftc8inx 3038 6 the the DT cord-010092-uftc8inx 3038 7 rate rate NN cord-010092-uftc8inx 3038 8 of of IN cord-010092-uftc8inx 3038 9 initially initially RB cord-010092-uftc8inx 3038 10 reactive reactive JJ cord-010092-uftc8inx 3038 11 samples sample NNS cord-010092-uftc8inx 3038 12 for for IN cord-010092-uftc8inx 3038 13 the the DT cord-010092-uftc8inx 3038 14 three three CD cord-010092-uftc8inx 3038 15 main main JJ cord-010092-uftc8inx 3038 16 screening screening NN cord-010092-uftc8inx 3038 17 assays assay NNS cord-010092-uftc8inx 3038 18 ( ( -LRB- cord-010092-uftc8inx 3038 19 HBsAg hbsag ADD cord-010092-uftc8inx 3038 20 , , , cord-010092-uftc8inx 3038 21 HIV HIV NNP cord-010092-uftc8inx 3038 22 , , , cord-010092-uftc8inx 3038 23 HCV HCV NNP cord-010092-uftc8inx 3038 24 ) ) -RRB- cord-010092-uftc8inx 3038 25 was be VBD cord-010092-uftc8inx 3038 26 also also RB cord-010092-uftc8inx 3038 27 comparable comparable JJ cord-010092-uftc8inx 3038 28 between between IN cord-010092-uftc8inx 3038 29 Alinity Alinity NNP cord-010092-uftc8inx 3038 30 s s POS cord-010092-uftc8inx 3038 31 ( ( -LRB- cord-010092-uftc8inx 3038 32 0.39 0.39 CD cord-010092-uftc8inx 3038 33 % % NN cord-010092-uftc8inx 3038 34 ) ) -RRB- cord-010092-uftc8inx 3038 35 and and CC cord-010092-uftc8inx 3038 36 PRISM prism NN cord-010092-uftc8inx 3038 37 assays assay NNS cord-010092-uftc8inx 3038 38 ( ( -LRB- cord-010092-uftc8inx 3038 39 0.34 0.34 CD cord-010092-uftc8inx 3038 40 % % NN cord-010092-uftc8inx 3038 41 ) ) -RRB- cord-010092-uftc8inx 3038 42 , , , cord-010092-uftc8inx 3038 43 mainly mainly RB cord-010092-uftc8inx 3038 44 attributable attributable JJ cord-010092-uftc8inx 3038 45 to to IN cord-010092-uftc8inx 3038 46 a a DT cord-010092-uftc8inx 3038 47 rather rather RB cord-010092-uftc8inx 3038 48 high high JJ cord-010092-uftc8inx 3038 49 number number NN cord-010092-uftc8inx 3038 50 of of IN cord-010092-uftc8inx 3038 51 initially initially RB cord-010092-uftc8inx 3038 52 reactive reactive JJ cord-010092-uftc8inx 3038 53 Alinity Alinity NNP cord-010092-uftc8inx 3038 54 s s POS cord-010092-uftc8inx 3038 55 HIV HIV NNP cord-010092-uftc8inx 3038 56 Ag Ag NNP cord-010092-uftc8inx 3038 57 / / SYM cord-010092-uftc8inx 3038 58 Ab Ab NNP cord-010092-uftc8inx 3038 59 results result NNS cord-010092-uftc8inx 3038 60 . . . cord-010092-uftc8inx 3039 1 This this DT cord-010092-uftc8inx 3039 2 was be VBD cord-010092-uftc8inx 3039 3 due due JJ cord-010092-uftc8inx 3039 4 to to IN cord-010092-uftc8inx 3039 5 initial initial JJ cord-010092-uftc8inx 3039 6 issues issue NNS cord-010092-uftc8inx 3039 7 with with IN cord-010092-uftc8inx 3039 8 blood blood NN cord-010092-uftc8inx 3039 9 collection collection NN cord-010092-uftc8inx 3039 10 tubes tube NNS cord-010092-uftc8inx 3039 11 that that WDT cord-010092-uftc8inx 3039 12 were be VBD cord-010092-uftc8inx 3039 13 resolved resolve VBN cord-010092-uftc8inx 3039 14 . . . cord-010092-uftc8inx 3040 1 As as IN cord-010092-uftc8inx 3040 2 a a DT cord-010092-uftc8inx 3040 3 result result NN cord-010092-uftc8inx 3040 4 in in IN cord-010092-uftc8inx 3040 5 December December NNP cord-010092-uftc8inx 3040 6 , , , cord-010092-uftc8inx 3040 7 the the DT cord-010092-uftc8inx 3040 8 rate rate NN cord-010092-uftc8inx 3040 9 of of IN cord-010092-uftc8inx 3040 10 initially initially RB cord-010092-uftc8inx 3040 11 reactive reactive JJ cord-010092-uftc8inx 3040 12 samples sample NNS cord-010092-uftc8inx 3040 13 decreased decrease VBD cord-010092-uftc8inx 3040 14 to to IN cord-010092-uftc8inx 3040 15 0.16 0.16 CD cord-010092-uftc8inx 3040 16 % % NN cord-010092-uftc8inx 3040 17 , , , cord-010092-uftc8inx 3040 18 which which WDT cord-010092-uftc8inx 3040 19 was be VBD cord-010092-uftc8inx 3040 20 significantly significantly RB cord-010092-uftc8inx 3040 21 lower low JJR cord-010092-uftc8inx 3040 22 than than IN cord-010092-uftc8inx 3040 23 for for IN cord-010092-uftc8inx 3040 24 the the DT cord-010092-uftc8inx 3040 25 three three CD cord-010092-uftc8inx 3040 26 PRISM prism NN cord-010092-uftc8inx 3040 27 assays assay NNS cord-010092-uftc8inx 3040 28 ( ( -LRB- cord-010092-uftc8inx 3040 29 0.33 0.33 CD cord-010092-uftc8inx 3040 30 % % NN cord-010092-uftc8inx 3040 31 ) ) -RRB- cord-010092-uftc8inx 3040 32 . . . cord-010092-uftc8inx 3041 1 Summary Summary NNP cord-010092-uftc8inx 3041 2 / / SYM cord-010092-uftc8inx 3041 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 3041 4 : : : cord-010092-uftc8inx 3042 1 The the DT cord-010092-uftc8inx 3042 2 introduction introduction NN cord-010092-uftc8inx 3042 3 of of IN cord-010092-uftc8inx 3042 4 the the DT cord-010092-uftc8inx 3042 5 Alinity Alinity NNP cord-010092-uftc8inx 3042 6 s s POS cord-010092-uftc8inx 3042 7 assays assay NNS cord-010092-uftc8inx 3042 8 lead lead VBP cord-010092-uftc8inx 3042 9 to to IN cord-010092-uftc8inx 3042 10 a a DT cord-010092-uftc8inx 3042 11 decrease decrease NN cord-010092-uftc8inx 3042 12 of of IN cord-010092-uftc8inx 3042 13 the the DT cord-010092-uftc8inx 3042 14 average average JJ cord-010092-uftc8inx 3042 15 repeat repeat NN cord-010092-uftc8inx 3042 16 reactive reactive JJ cord-010092-uftc8inx 3042 17 test test NN cord-010092-uftc8inx 3042 18 results result NNS cord-010092-uftc8inx 3042 19 ( ( -LRB- cord-010092-uftc8inx 3042 20 HBsAg hbsag ADD cord-010092-uftc8inx 3042 21 , , , cord-010092-uftc8inx 3042 22 HIV HIV NNP cord-010092-uftc8inx 3042 23 , , , cord-010092-uftc8inx 3042 24 HCV HCV NNP cord-010092-uftc8inx 3042 25 ) ) -RRB- cord-010092-uftc8inx 3042 26 by by IN cord-010092-uftc8inx 3042 27 0.17 0.17 CD cord-010092-uftc8inx 3042 28 % % NN cord-010092-uftc8inx 3042 29 as as IN cord-010092-uftc8inx 3042 30 compared compare VBN cord-010092-uftc8inx 3042 31 to to IN cord-010092-uftc8inx 3042 32 the the DT cord-010092-uftc8inx 3042 33 PRISM prism NN cord-010092-uftc8inx 3042 34 , , , cord-010092-uftc8inx 3042 35 mainly mainly RB cord-010092-uftc8inx 3042 36 due due IN cord-010092-uftc8inx 3042 37 to to IN cord-010092-uftc8inx 3042 38 a a DT cord-010092-uftc8inx 3042 39 lower lower RBR cord-010092-uftc8inx 3042 40 false false JJ cord-010092-uftc8inx 3042 41 reactive reactive JJ cord-010092-uftc8inx 3042 42 rate rate NN cord-010092-uftc8inx 3042 43 of of IN cord-010092-uftc8inx 3042 44 the the DT cord-010092-uftc8inx 3042 45 Alinity Alinity NNP cord-010092-uftc8inx 3042 46 s s POS cord-010092-uftc8inx 3042 47 Anti Anti NNP cord-010092-uftc8inx 3042 48 - - NNP cord-010092-uftc8inx 3042 49 HCV HCV NNP cord-010092-uftc8inx 3042 50 assay assay NN cord-010092-uftc8inx 3042 51 . . . cord-010092-uftc8inx 3043 1 This this DT cord-010092-uftc8inx 3043 2 will will MD cord-010092-uftc8inx 3043 3 be be VB cord-010092-uftc8inx 3043 4 further further RB cord-010092-uftc8inx 3043 5 investigated investigate VBN cord-010092-uftc8inx 3043 6 for for IN cord-010092-uftc8inx 3043 7 first first JJ cord-010092-uftc8inx 3043 8 time time NN cord-010092-uftc8inx 3043 9 and and CC cord-010092-uftc8inx 3043 10 multiple multiple JJ cord-010092-uftc8inx 3043 11 time time NN cord-010092-uftc8inx 3043 12 donors donor NNS cord-010092-uftc8inx 3043 13 . . . cord-010092-uftc8inx 3044 1 With with IN cord-010092-uftc8inx 3044 2 the the DT cord-010092-uftc8inx 3044 3 implementation implementation NN cord-010092-uftc8inx 3044 4 of of IN cord-010092-uftc8inx 3044 5 the the DT cord-010092-uftc8inx 3044 6 Alinity Alinity NNP cord-010092-uftc8inx 3044 7 s s NN cord-010092-uftc8inx 3044 8 at at IN cord-010092-uftc8inx 3044 9 Sanquin Sanquin NNP cord-010092-uftc8inx 3044 10 we -PRON- PRP cord-010092-uftc8inx 3044 11 aimed aim VBD cord-010092-uftc8inx 3044 12 to to TO cord-010092-uftc8inx 3044 13 improve improve VB cord-010092-uftc8inx 3044 14 not not RB cord-010092-uftc8inx 3044 15 only only RB cord-010092-uftc8inx 3044 16 the the DT cord-010092-uftc8inx 3044 17 operational operational JJ cord-010092-uftc8inx 3044 18 efficiency efficiency NN cord-010092-uftc8inx 3044 19 but but CC cord-010092-uftc8inx 3044 20 also also RB cord-010092-uftc8inx 3044 21 to to TO cord-010092-uftc8inx 3044 22 further further RB cord-010092-uftc8inx 3044 23 minimize minimize VB cord-010092-uftc8inx 3044 24 unjustified unjustified JJ cord-010092-uftc8inx 3044 25 disapproval disapproval NN cord-010092-uftc8inx 3044 26 of of IN cord-010092-uftc8inx 3044 27 donors donor NNS cord-010092-uftc8inx 3044 28 . . . cord-010092-uftc8inx 3045 1 These these DT cord-010092-uftc8inx 3045 2 first first JJ cord-010092-uftc8inx 3045 3 data datum NNS cord-010092-uftc8inx 3045 4 show show VBP cord-010092-uftc8inx 3045 5 that that IN cord-010092-uftc8inx 3045 6 the the DT cord-010092-uftc8inx 3045 7 low low JJ cord-010092-uftc8inx 3045 8 initial initial NN cord-010092-uftc8inx 3045 9 and and CC cord-010092-uftc8inx 3045 10 repeat repeat VB cord-010092-uftc8inx 3045 11 reactive reactive JJ cord-010092-uftc8inx 3045 12 rates rate NNS cord-010092-uftc8inx 3045 13 of of IN cord-010092-uftc8inx 3045 14 the the DT cord-010092-uftc8inx 3045 15 Alinity Alinity NNP cord-010092-uftc8inx 3045 16 s s POS cord-010092-uftc8inx 3045 17 assays assay NNS cord-010092-uftc8inx 3045 18 indeed indeed RB cord-010092-uftc8inx 3045 19 have have VBP cord-010092-uftc8inx 3045 20 a a DT cord-010092-uftc8inx 3045 21 positive positive JJ cord-010092-uftc8inx 3045 22 impact impact NN cord-010092-uftc8inx 3045 23 on on IN cord-010092-uftc8inx 3045 24 unnecessary unnecessary JJ cord-010092-uftc8inx 3045 25 deferrals deferral NNS cord-010092-uftc8inx 3045 26 of of IN cord-010092-uftc8inx 3045 27 donations donation NNS cord-010092-uftc8inx 3045 28 and and CC cord-010092-uftc8inx 3045 29 donors donor NNS cord-010092-uftc8inx 3045 30 . . . cord-010092-uftc8inx 3046 1 Background background NN cord-010092-uftc8inx 3046 2 : : : cord-010092-uftc8inx 3047 1 In in IN cord-010092-uftc8inx 3047 2 blood blood NN cord-010092-uftc8inx 3047 3 banks bank NNS cord-010092-uftc8inx 3047 4 , , , cord-010092-uftc8inx 3047 5 testing test VBG cord-010092-uftc8inx 3047 6 all all DT cord-010092-uftc8inx 3047 7 blood blood NN cord-010092-uftc8inx 3047 8 donations donation NNS cord-010092-uftc8inx 3047 9 for for IN cord-010092-uftc8inx 3047 10 markers marker NNS cord-010092-uftc8inx 3047 11 of of IN cord-010092-uftc8inx 3047 12 infectious infectious JJ cord-010092-uftc8inx 3047 13 diseases disease NNS cord-010092-uftc8inx 3047 14 plays play VBZ cord-010092-uftc8inx 3047 15 an an DT cord-010092-uftc8inx 3047 16 important important JJ cord-010092-uftc8inx 3047 17 role role NN cord-010092-uftc8inx 3047 18 in in IN cord-010092-uftc8inx 3047 19 maintaining maintain VBG cord-010092-uftc8inx 3047 20 the the DT cord-010092-uftc8inx 3047 21 safety safety NN cord-010092-uftc8inx 3047 22 of of IN cord-010092-uftc8inx 3047 23 blood blood NN cord-010092-uftc8inx 3047 24 transfusions transfusion NNS cord-010092-uftc8inx 3047 25 . . . cord-010092-uftc8inx 3048 1 Mandatory mandatory JJ cord-010092-uftc8inx 3048 2 serological serological JJ cord-010092-uftc8inx 3048 3 testing testing NN cord-010092-uftc8inx 3048 4 in in IN cord-010092-uftc8inx 3048 5 Switzerland Switzerland NNP cord-010092-uftc8inx 3048 6 is be VBZ cord-010092-uftc8inx 3048 7 performed perform VBN cord-010092-uftc8inx 3048 8 for for IN cord-010092-uftc8inx 3048 9 anti anti JJ cord-010092-uftc8inx 3048 10 - - NNP cord-010092-uftc8inx 3048 11 HCV HCV NNP cord-010092-uftc8inx 3048 12 , , , cord-010092-uftc8inx 3048 13 HIV HIV NNP cord-010092-uftc8inx 3048 14 Ag Ag NNP cord-010092-uftc8inx 3048 15 / / SYM cord-010092-uftc8inx 3048 16 Ab Ab NNP cord-010092-uftc8inx 3048 17 , , , cord-010092-uftc8inx 3048 18 HBsAg hbsag ADD cord-010092-uftc8inx 3048 19 and and CC cord-010092-uftc8inx 3048 20 Syphilis Syphilis NNP cord-010092-uftc8inx 3048 21 . . . cord-010092-uftc8inx 3049 1 Highly highly RB cord-010092-uftc8inx 3049 2 specific specific JJ cord-010092-uftc8inx 3049 3 and and CC cord-010092-uftc8inx 3049 4 sensitive sensitive JJ cord-010092-uftc8inx 3049 5 tests test NNS cord-010092-uftc8inx 3049 6 with with IN cord-010092-uftc8inx 3049 7 corresponding correspond VBG cord-010092-uftc8inx 3049 8 automation automation NN cord-010092-uftc8inx 3049 9 are be VBP cord-010092-uftc8inx 3049 10 essential essential JJ cord-010092-uftc8inx 3049 11 for for IN cord-010092-uftc8inx 3049 12 this this DT cord-010092-uftc8inx 3049 13 purpose purpose NN cord-010092-uftc8inx 3049 14 . . . cord-010092-uftc8inx 3050 1 Aims aim VBZ cord-010092-uftc8inx 3050 2 : : : cord-010092-uftc8inx 3051 1 A a DT cord-010092-uftc8inx 3051 2 comparative comparative JJ cord-010092-uftc8inx 3051 3 study study NN cord-010092-uftc8inx 3051 4 was be VBD cord-010092-uftc8inx 3051 5 carried carry VBN cord-010092-uftc8inx 3051 6 out out RP cord-010092-uftc8inx 3051 7 to to TO cord-010092-uftc8inx 3051 8 evaluate evaluate VB cord-010092-uftc8inx 3051 9 the the DT cord-010092-uftc8inx 3051 10 usability usability NN cord-010092-uftc8inx 3051 11 of of IN cord-010092-uftc8inx 3051 12 the the DT cord-010092-uftc8inx 3051 13 newly newly RB cord-010092-uftc8inx 3051 14 launched launch VBN cord-010092-uftc8inx 3051 15 Alinity Alinity NNP cord-010092-uftc8inx 3051 16 s s NNP cord-010092-uftc8inx 3051 17 System System NNP cord-010092-uftc8inx 3051 18 ( ( -LRB- cord-010092-uftc8inx 3051 19 Abbott Abbott NNP cord-010092-uftc8inx 3051 20 ) ) -RRB- cord-010092-uftc8inx 3051 21 and and CC cord-010092-uftc8inx 3051 22 the the DT cord-010092-uftc8inx 3051 23 specificity specificity NN cord-010092-uftc8inx 3051 24 of of IN cord-010092-uftc8inx 3051 25 the the DT cord-010092-uftc8inx 3051 26 infectious infectious JJ cord-010092-uftc8inx 3051 27 disease disease NN cord-010092-uftc8inx 3051 28 parameters parameter NNS cord-010092-uftc8inx 3051 29 HBsAg hbsag ADD cord-010092-uftc8inx 3051 30 , , , cord-010092-uftc8inx 3051 31 Anti Anti NNP cord-010092-uftc8inx 3051 32 - - NNP cord-010092-uftc8inx 3051 33 HCV HCV NNP cord-010092-uftc8inx 3051 34 , , , cord-010092-uftc8inx 3051 35 HIV HIV NNP cord-010092-uftc8inx 3051 36 Combo Combo NNP cord-010092-uftc8inx 3051 37 and and CC cord-010092-uftc8inx 3051 38 Syphilis Syphilis NNP cord-010092-uftc8inx 3051 39 ( ( -LRB- cord-010092-uftc8inx 3051 40 Abbott Abbott NNP cord-010092-uftc8inx 3051 41 ) ) -RRB- cord-010092-uftc8inx 3051 42 with with IN cord-010092-uftc8inx 3051 43 the the DT cord-010092-uftc8inx 3051 44 currently currently RB cord-010092-uftc8inx 3051 45 used use VBN cord-010092-uftc8inx 3051 46 ELISA ELISA NNP cord-010092-uftc8inx 3051 47 methods method NNS cord-010092-uftc8inx 3051 48 on on IN cord-010092-uftc8inx 3051 49 the the DT cord-010092-uftc8inx 3051 50 Quadriga Quadriga NNP cord-010092-uftc8inx 3051 51 BeFree BeFree NNP cord-010092-uftc8inx 3051 52 System System NNP cord-010092-uftc8inx 3051 53 ( ( -LRB- cord-010092-uftc8inx 3051 54 all all DT cord-010092-uftc8inx 3051 55 DiaSorin DiaSorin NNS cord-010092-uftc8inx 3051 56 , , , cord-010092-uftc8inx 3051 57 formerly formerly RB cord-010092-uftc8inx 3051 58 Siemens Siemens NNP cord-010092-uftc8inx 3051 59 Healthcare Healthcare NNP cord-010092-uftc8inx 3051 60 Diagnostics Diagnostics NNPS cord-010092-uftc8inx 3051 61 ) ) -RRB- cord-010092-uftc8inx 3051 62 . . . cord-010092-uftc8inx 3052 1 Methods method NNS cord-010092-uftc8inx 3052 2 : : : cord-010092-uftc8inx 3053 1 The the DT cord-010092-uftc8inx 3053 2 study study NN cord-010092-uftc8inx 3053 3 took take VBD cord-010092-uftc8inx 3053 4 place place NN cord-010092-uftc8inx 3053 5 at at IN cord-010092-uftc8inx 3053 6 the the DT cord-010092-uftc8inx 3053 7 Interregional Interregional NNP cord-010092-uftc8inx 3053 8 Blood Blood NNP cord-010092-uftc8inx 3053 9 Transfusion Transfusion NNP cord-010092-uftc8inx 3053 10 Service Service NNP cord-010092-uftc8inx 3053 11 in in IN cord-010092-uftc8inx 3053 12 Berne Berne NNP cord-010092-uftc8inx 3053 13 , , , cord-010092-uftc8inx 3053 14 Switzerland Switzerland NNP cord-010092-uftc8inx 3053 15 . . . cord-010092-uftc8inx 3054 1 The the DT cord-010092-uftc8inx 3054 2 specificity specificity NN cord-010092-uftc8inx 3054 3 of of IN cord-010092-uftc8inx 3054 4 the the DT cord-010092-uftc8inx 3054 5 parameters parameter NNS cord-010092-uftc8inx 3054 6 was be VBD cord-010092-uftc8inx 3054 7 studied study VBN cord-010092-uftc8inx 3054 8 on on IN cord-010092-uftc8inx 3054 9 2,748 2,748 CD cord-010092-uftc8inx 3054 10 blood blood NN cord-010092-uftc8inx 3054 11 donor donor NN cord-010092-uftc8inx 3054 12 sera sera NNP cord-010092-uftc8inx 3054 13 from from IN cord-010092-uftc8inx 3054 14 both both DT cord-010092-uftc8inx 3054 15 first first JJ cord-010092-uftc8inx 3054 16 time time NN cord-010092-uftc8inx 3054 17 and and CC cord-010092-uftc8inx 3054 18 repeat repeat VB cord-010092-uftc8inx 3054 19 donors donor NNS cord-010092-uftc8inx 3054 20 . . . cord-010092-uftc8inx 3055 1 The the DT cord-010092-uftc8inx 3055 2 samples sample NNS cord-010092-uftc8inx 3055 3 were be VBD cord-010092-uftc8inx 3055 4 tested test VBN cord-010092-uftc8inx 3055 5 first first RB cord-010092-uftc8inx 3055 6 on on IN cord-010092-uftc8inx 3055 7 the the DT cord-010092-uftc8inx 3055 8 Quadriga Quadriga NNP cord-010092-uftc8inx 3055 9 Be be VB cord-010092-uftc8inx 3055 10 Free free JJ cord-010092-uftc8inx 3055 11 System system NN cord-010092-uftc8inx 3055 12 with with IN cord-010092-uftc8inx 3055 13 Enzygnost Enzygnost NNP cord-010092-uftc8inx 3056 1 HBsAg HBsAg NNP cord-010092-uftc8inx 3056 2 6.0 6.0 CD cord-010092-uftc8inx 3057 1 , , , cord-010092-uftc8inx 3057 2 Enzygnost Enzygnost NNP cord-010092-uftc8inx 3057 3 Anti Anti NNP cord-010092-uftc8inx 3057 4 - - NNP cord-010092-uftc8inx 3057 5 HCV HCV NNP cord-010092-uftc8inx 3057 6 4.0 4.0 CD cord-010092-uftc8inx 3057 7 , , , cord-010092-uftc8inx 3057 8 and and CC cord-010092-uftc8inx 3057 9 Enzygnost Enzygnost NNP cord-010092-uftc8inx 3057 10 HIV HIV NNP cord-010092-uftc8inx 3057 11 Integral Integral NNP cord-010092-uftc8inx 3057 12 4 4 CD cord-010092-uftc8inx 3057 13 assays assay NNS cord-010092-uftc8inx 3057 14 and and CC cord-010092-uftc8inx 3057 15 on on IN cord-010092-uftc8inx 3057 16 the the DT cord-010092-uftc8inx 3057 17 PK7300 pk7300 NN cord-010092-uftc8inx 3057 18 with with IN cord-010092-uftc8inx 3057 19 the the DT cord-010092-uftc8inx 3057 20 newbio newbio NNP cord-010092-uftc8inx 3057 21 - - HYPH cord-010092-uftc8inx 3057 22 pk pk NNP cord-010092-uftc8inx 3057 23 TPHA TPHA NNP cord-010092-uftc8inx 3057 24 assay assay NN cord-010092-uftc8inx 3057 25 ( ( -LRB- cord-010092-uftc8inx 3057 26 Newmarket Newmarket NNP cord-010092-uftc8inx 3057 27 Biomedical Biomedical NNP cord-010092-uftc8inx 3057 28 ) ) -RRB- cord-010092-uftc8inx 3057 29 . . . cord-010092-uftc8inx 3058 1 All all DT cord-010092-uftc8inx 3058 2 samples sample NNS cord-010092-uftc8inx 3058 3 were be VBD cord-010092-uftc8inx 3058 4 retested reteste VBN cord-010092-uftc8inx 3058 5 on on IN cord-010092-uftc8inx 3058 6 the the DT cord-010092-uftc8inx 3058 7 same same JJ cord-010092-uftc8inx 3058 8 day day NN cord-010092-uftc8inx 3058 9 with with IN cord-010092-uftc8inx 3058 10 HBsAg hbsag ADD cord-010092-uftc8inx 3058 11 , , , cord-010092-uftc8inx 3058 12 Anti Anti NNP cord-010092-uftc8inx 3058 13 - - NNP cord-010092-uftc8inx 3058 14 HCV HCV NNP cord-010092-uftc8inx 3058 15 , , , cord-010092-uftc8inx 3058 16 HIV HIV NNP cord-010092-uftc8inx 3058 17 Combo Combo NNP cord-010092-uftc8inx 3058 18 and and CC cord-010092-uftc8inx 3058 19 Syphilis Syphilis NNP cord-010092-uftc8inx 3058 20 on on IN cord-010092-uftc8inx 3058 21 the the DT cord-010092-uftc8inx 3058 22 Alinity Alinity NNP cord-010092-uftc8inx 3058 23 s. s. NNP cord-010092-uftc8inx 3058 24 Initial initial JJ cord-010092-uftc8inx 3058 25 reactive reactive JJ cord-010092-uftc8inx 3058 26 samples sample NNS cord-010092-uftc8inx 3058 27 were be VBD cord-010092-uftc8inx 3058 28 repeated repeat VBN cord-010092-uftc8inx 3058 29 in in IN cord-010092-uftc8inx 3058 30 duplicate duplicate NN cord-010092-uftc8inx 3058 31 . . . cord-010092-uftc8inx 3059 1 Discriminatory discriminatory JJ cord-010092-uftc8inx 3059 2 tests test NNS cord-010092-uftc8inx 3059 3 were be VBD cord-010092-uftc8inx 3059 4 carried carry VBN cord-010092-uftc8inx 3059 5 out out RP cord-010092-uftc8inx 3059 6 for for IN cord-010092-uftc8inx 3059 7 repeatedly repeatedly RB cord-010092-uftc8inx 3059 8 reactive reactive JJ cord-010092-uftc8inx 3059 9 samples sample NNS cord-010092-uftc8inx 3059 10 using use VBG cord-010092-uftc8inx 3059 11 alternative alternative JJ cord-010092-uftc8inx 3059 12 screening screening NN cord-010092-uftc8inx 3059 13 tests test NNS cord-010092-uftc8inx 3059 14 and and CC cord-010092-uftc8inx 3059 15 neutralisation neutralisation NN cord-010092-uftc8inx 3059 16 ( ( -LRB- cord-010092-uftc8inx 3059 17 for for IN cord-010092-uftc8inx 3059 18 HBsAg hbsag ADD cord-010092-uftc8inx 3059 19 ) ) -RRB- cord-010092-uftc8inx 3059 20 on on IN cord-010092-uftc8inx 3059 21 an an DT cord-010092-uftc8inx 3059 22 Abbott Abbott NNP cord-010092-uftc8inx 3059 23 Architect Architect NNP cord-010092-uftc8inx 3059 24 i1000 i1000 NNP cord-010092-uftc8inx 3059 25 system system NN cord-010092-uftc8inx 3059 26 and and CC cord-010092-uftc8inx 3059 27 immunoblots immunoblot NNS cord-010092-uftc8inx 3059 28 ( ( -LRB- cord-010092-uftc8inx 3059 29 HIV- HIV- NNP cord-010092-uftc8inx 3059 30 , , , cord-010092-uftc8inx 3059 31 HCV- HCV- NNP cord-010092-uftc8inx 3059 32 , , , cord-010092-uftc8inx 3059 33 Syphilis Syphilis NNP cord-010092-uftc8inx 3059 34 - - HYPH cord-010092-uftc8inx 3059 35 INNO INNO NNP cord-010092-uftc8inx 3059 36 - - HYPH cord-010092-uftc8inx 3059 37 LIA LIA NNP cord-010092-uftc8inx 3059 38 , , , cord-010092-uftc8inx 3059 39 Fujirebio Fujirebio NNP cord-010092-uftc8inx 3059 40 ) ) -RRB- cord-010092-uftc8inx 3059 41 . . . cord-010092-uftc8inx 3060 1 For for IN cord-010092-uftc8inx 3060 2 all all DT cord-010092-uftc8inx 3060 3 samples sample NNS cord-010092-uftc8inx 3060 4 , , , cord-010092-uftc8inx 3060 5 results result NNS cord-010092-uftc8inx 3060 6 from from IN cord-010092-uftc8inx 3060 7 our -PRON- PRP$ cord-010092-uftc8inx 3060 8 routine routine JJ cord-010092-uftc8inx 3060 9 individual individual JJ cord-010092-uftc8inx 3060 10 donation donation NN cord-010092-uftc8inx 3060 11 nucleic nucleic VBD cord-010092-uftc8inx 3060 12 acid acid NN cord-010092-uftc8inx 3060 13 testing testing NN cord-010092-uftc8inx 3060 14 ( ( -LRB- cord-010092-uftc8inx 3060 15 HCV HCV NNP cord-010092-uftc8inx 3060 16 , , , cord-010092-uftc8inx 3060 17 HIV HIV NNP cord-010092-uftc8inx 3060 18 , , , cord-010092-uftc8inx 3060 19 HBV HBV NNP cord-010092-uftc8inx 3060 20 , , , cord-010092-uftc8inx 3060 21 Roche Roche NNP cord-010092-uftc8inx 3060 22 cobas cobas NNP cord-010092-uftc8inx 3060 23 8800 8800 CD cord-010092-uftc8inx 3060 24 system system NN cord-010092-uftc8inx 3060 25 ) ) -RRB- cord-010092-uftc8inx 3060 26 were be VBD cord-010092-uftc8inx 3060 27 available available JJ cord-010092-uftc8inx 3060 28 . . . cord-010092-uftc8inx 3061 1 Results result NNS cord-010092-uftc8inx 3061 2 : : : cord-010092-uftc8inx 3062 1 Based base VBN cord-010092-uftc8inx 3062 2 on on IN cord-010092-uftc8inx 3062 3 the the DT cord-010092-uftc8inx 3062 4 results result NNS cord-010092-uftc8inx 3062 5 from from IN cord-010092-uftc8inx 3062 6 testing test VBG cord-010092-uftc8inx 3062 7 2,748 2,748 CD cord-010092-uftc8inx 3062 8 blood blood NN cord-010092-uftc8inx 3062 9 donations donation NNS cord-010092-uftc8inx 3062 10 , , , cord-010092-uftc8inx 3062 11 the the DT cord-010092-uftc8inx 3062 12 observed observed JJ cord-010092-uftc8inx 3062 13 specificities specificity NNS cord-010092-uftc8inx 3062 14 of of IN cord-010092-uftc8inx 3062 15 Alinity Alinity NNP cord-010092-uftc8inx 3062 16 s s POS cord-010092-uftc8inx 3062 17 assays assay NNS cord-010092-uftc8inx 3062 18 ( ( -LRB- cord-010092-uftc8inx 3062 19 A a NN cord-010092-uftc8inx 3062 20 ) ) -RRB- cord-010092-uftc8inx 3062 21 and and CC cord-010092-uftc8inx 3062 22 Enzygnost Enzygnost NNP cord-010092-uftc8inx 3062 23 assays assay NNS cord-010092-uftc8inx 3063 1 ( ( -LRB- cord-010092-uftc8inx 3063 2 Summary Summary NNP cord-010092-uftc8inx 3063 3 / / SYM cord-010092-uftc8inx 3063 4 Conclusions Conclusions NNPS cord-010092-uftc8inx 3063 5 : : : cord-010092-uftc8inx 3064 1 The the DT cord-010092-uftc8inx 3064 2 Alinity Alinity NNP cord-010092-uftc8inx 3064 3 s s NNP cord-010092-uftc8inx 3064 4 System System NNP cord-010092-uftc8inx 3064 5 was be VBD cord-010092-uftc8inx 3064 6 easy easy JJ cord-010092-uftc8inx 3064 7 to to TO cord-010092-uftc8inx 3064 8 use use VB cord-010092-uftc8inx 3064 9 by by IN cord-010092-uftc8inx 3064 10 the the DT cord-010092-uftc8inx 3064 11 operators operator NNS cord-010092-uftc8inx 3064 12 after after IN cord-010092-uftc8inx 3064 13 a a DT cord-010092-uftc8inx 3064 14 very very RB cord-010092-uftc8inx 3064 15 short short JJ cord-010092-uftc8inx 3064 16 introductory introductory JJ cord-010092-uftc8inx 3064 17 training training NN cord-010092-uftc8inx 3064 18 and and CC cord-010092-uftc8inx 3064 19 provides provide VBZ cord-010092-uftc8inx 3064 20 good good JJ cord-010092-uftc8inx 3064 21 operational operational JJ cord-010092-uftc8inx 3064 22 efficiency efficiency NN cord-010092-uftc8inx 3064 23 such such JJ cord-010092-uftc8inx 3064 24 as as IN cord-010092-uftc8inx 3064 25 high high JJ cord-010092-uftc8inx 3064 26 throughput throughput NN cord-010092-uftc8inx 3064 27 even even RB cord-010092-uftc8inx 3064 28 when when WRB cord-010092-uftc8inx 3064 29 selective selective JJ cord-010092-uftc8inx 3064 30 testing testing NN cord-010092-uftc8inx 3064 31 for for IN cord-010092-uftc8inx 3064 32 samples sample NNS cord-010092-uftc8inx 3064 33 is be VBZ cord-010092-uftc8inx 3064 34 needed need VBN cord-010092-uftc8inx 3064 35 . . . cord-010092-uftc8inx 3065 1 The the DT cord-010092-uftc8inx 3065 2 observed observed JJ cord-010092-uftc8inx 3065 3 specificity specificity NN cord-010092-uftc8inx 3065 4 of of IN cord-010092-uftc8inx 3065 5 Abbott Abbott NNP cord-010092-uftc8inx 3065 6 Alinity Alinity NNP cord-010092-uftc8inx 3065 7 s s POS cord-010092-uftc8inx 3065 8 versus versus IN cord-010092-uftc8inx 3065 9 Siemens Siemens NNP cord-010092-uftc8inx 3065 10 Enzygnost Enzygnost NNP cord-010092-uftc8inx 3065 11 assays assay NNS cord-010092-uftc8inx 3065 12 is be VBZ cord-010092-uftc8inx 3065 13 comparable comparable JJ cord-010092-uftc8inx 3065 14 in in IN cord-010092-uftc8inx 3065 15 a a DT cord-010092-uftc8inx 3065 16 blood blood NN cord-010092-uftc8inx 3065 17 donor donor NN cord-010092-uftc8inx 3065 18 screening screening NN cord-010092-uftc8inx 3065 19 setting setting NN cord-010092-uftc8inx 3065 20 . . . cord-010092-uftc8inx 3066 1 Unfortunately unfortunately RB cord-010092-uftc8inx 3066 2 , , , cord-010092-uftc8inx 3066 3 we -PRON- PRP cord-010092-uftc8inx 3066 4 were be VBD cord-010092-uftc8inx 3066 5 not not RB cord-010092-uftc8inx 3066 6 able able JJ cord-010092-uftc8inx 3066 7 to to TO cord-010092-uftc8inx 3066 8 analyse analyse VB cord-010092-uftc8inx 3066 9 statistically statistically RB cord-010092-uftc8inx 3066 10 the the DT cord-010092-uftc8inx 3066 11 specificity specificity NN cord-010092-uftc8inx 3066 12 data datum NNS cord-010092-uftc8inx 3066 13 due due JJ cord-010092-uftc8inx 3066 14 to to IN cord-010092-uftc8inx 3066 15 the the DT cord-010092-uftc8inx 3066 16 insufficient insufficient JJ cord-010092-uftc8inx 3066 17 number number NN cord-010092-uftc8inx 3066 18 of of IN cord-010092-uftc8inx 3066 19 donor donor NN cord-010092-uftc8inx 3066 20 samples sample NNS cord-010092-uftc8inx 3066 21 tested test VBN cord-010092-uftc8inx 3066 22 in in IN cord-010092-uftc8inx 3066 23 parallel parallel NN cord-010092-uftc8inx 3066 24 . . . cord-010092-uftc8inx 3067 1 It -PRON- PRP cord-010092-uftc8inx 3067 2 is be VBZ cord-010092-uftc8inx 3067 3 worth worth JJ cord-010092-uftc8inx 3067 4 mentioning mention VBG cord-010092-uftc8inx 3067 5 that that IN cord-010092-uftc8inx 3067 6 around around IN cord-010092-uftc8inx 3067 7 90 90 CD cord-010092-uftc8inx 3067 8 % % NN cord-010092-uftc8inx 3067 9 of of IN cord-010092-uftc8inx 3067 10 the the DT cord-010092-uftc8inx 3067 11 samples sample NNS cord-010092-uftc8inx 3067 12 included include VBN cord-010092-uftc8inx 3067 13 in in IN cord-010092-uftc8inx 3067 14 the the DT cord-010092-uftc8inx 3067 15 study study NN cord-010092-uftc8inx 3067 16 derived derive VBN cord-010092-uftc8inx 3067 17 from from IN cord-010092-uftc8inx 3067 18 repeat repeat NN cord-010092-uftc8inx 3067 19 donors donor NNS cord-010092-uftc8inx 3067 20 who who WP cord-010092-uftc8inx 3067 21 had have VBD cord-010092-uftc8inx 3067 22 been be VBN cord-010092-uftc8inx 3067 23 previously previously RB cord-010092-uftc8inx 3067 24 tested test VBN cord-010092-uftc8inx 3067 25 with with IN cord-010092-uftc8inx 3067 26 the the DT cord-010092-uftc8inx 3067 27 Enzygnost Enzygnost NNP cord-010092-uftc8inx 3067 28 assays assay NNS cord-010092-uftc8inx 3067 29 but but CC cord-010092-uftc8inx 3067 30 were be VBD cord-010092-uftc8inx 3067 31 " " `` cord-010092-uftc8inx 3067 32 first first JJ cord-010092-uftc8inx 3067 33 time time NN cord-010092-uftc8inx 3067 34 donors donor NNS cord-010092-uftc8inx 3067 35 " " '' cord-010092-uftc8inx 3067 36 for for IN cord-010092-uftc8inx 3067 37 the the DT cord-010092-uftc8inx 3067 38 Alinity Alinity NNP cord-010092-uftc8inx 3067 39 s s POS cord-010092-uftc8inx 3067 40 assays assay NNS cord-010092-uftc8inx 3067 41 . . . cord-010092-uftc8inx 3068 1 All all DT cord-010092-uftc8inx 3068 2 four four CD cord-010092-uftc8inx 3068 3 assays assay NNS cord-010092-uftc8inx 3068 4 from from IN cord-010092-uftc8inx 3068 5 both both DT cord-010092-uftc8inx 3068 6 systems system NNS cord-010092-uftc8inx 3068 7 exhibit exhibit VBP cord-010092-uftc8inx 3068 8 a a DT cord-010092-uftc8inx 3068 9 very very RB cord-010092-uftc8inx 3068 10 good good JJ cord-010092-uftc8inx 3068 11 specificity specificity NN cord-010092-uftc8inx 3068 12 and and CC cord-010092-uftc8inx 3068 13 are be VBP cord-010092-uftc8inx 3068 14 highly highly RB cord-010092-uftc8inx 3068 15 suitable suitable JJ cord-010092-uftc8inx 3068 16 and and CC cord-010092-uftc8inx 3068 17 practicable practicable JJ cord-010092-uftc8inx 3068 18 for for IN cord-010092-uftc8inx 3068 19 routine routine JJ cord-010092-uftc8inx 3068 20 blood blood NN cord-010092-uftc8inx 3068 21 donor donor NN cord-010092-uftc8inx 3068 22 screening screening NN cord-010092-uftc8inx 3068 23 . . . cord-010092-uftc8inx 3069 1 Background background NN cord-010092-uftc8inx 3069 2 : : : cord-010092-uftc8inx 3070 1 Effective effective JJ cord-010092-uftc8inx 3070 2 screening screening NN cord-010092-uftc8inx 3070 3 for for IN cord-010092-uftc8inx 3070 4 transfusion transfusion NN cord-010092-uftc8inx 3070 5 - - HYPH cord-010092-uftc8inx 3070 6 transmissible transmissible JJ cord-010092-uftc8inx 3070 7 infections infection NNS cord-010092-uftc8inx 3070 8 is be VBZ cord-010092-uftc8inx 3070 9 essential essential JJ cord-010092-uftc8inx 3070 10 to to TO cord-010092-uftc8inx 3070 11 ensure ensure VB cord-010092-uftc8inx 3070 12 safe safe JJ cord-010092-uftc8inx 3070 13 blood blood NN cord-010092-uftc8inx 3070 14 transfusions transfusion NNS cord-010092-uftc8inx 3070 15 . . . cord-010092-uftc8inx 3071 1 The the DT cord-010092-uftc8inx 3071 2 World World NNP cord-010092-uftc8inx 3071 3 Health Health NNP cord-010092-uftc8inx 3071 4 Organization Organization NNP cord-010092-uftc8inx 3071 5 recommends recommend VBZ cord-010092-uftc8inx 3071 6 mandatory mandatory JJ cord-010092-uftc8inx 3071 7 serological serological JJ cord-010092-uftc8inx 3071 8 testing testing NN cord-010092-uftc8inx 3071 9 of of IN cord-010092-uftc8inx 3071 10 blood blood NN cord-010092-uftc8inx 3071 11 donations donation NNS cord-010092-uftc8inx 3071 12 for for IN cord-010092-uftc8inx 3071 13 human human JJ cord-010092-uftc8inx 3071 14 immunodeficiency immunodeficiency NN cord-010092-uftc8inx 3071 15 virus virus NN cord-010092-uftc8inx 3071 16 ( ( -LRB- cord-010092-uftc8inx 3071 17 HIV HIV NNP cord-010092-uftc8inx 3071 18 ) ) -RRB- cord-010092-uftc8inx 3071 19 , , , cord-010092-uftc8inx 3071 20 hepatitis hepatitis NNP cord-010092-uftc8inx 3071 21 B B NNP cord-010092-uftc8inx 3071 22 ( ( -LRB- cord-010092-uftc8inx 3071 23 HBV)/C HBV)/C NNP cord-010092-uftc8inx 3071 24 ( ( -LRB- cord-010092-uftc8inx 3071 25 HCV HCV NNP cord-010092-uftc8inx 3071 26 ) ) -RRB- cord-010092-uftc8inx 3071 27 , , , cord-010092-uftc8inx 3071 28 and and CC cord-010092-uftc8inx 3071 29 syphilis syphili NNS cord-010092-uftc8inx 3071 30 . . . cord-010092-uftc8inx 3072 1 Due due IN cord-010092-uftc8inx 3072 2 to to IN cord-010092-uftc8inx 3072 3 increasing increase VBG cord-010092-uftc8inx 3072 4 demands demand NNS cord-010092-uftc8inx 3072 5 on on IN cord-010092-uftc8inx 3072 6 clinical clinical JJ cord-010092-uftc8inx 3072 7 laboratories laboratory NNS cord-010092-uftc8inx 3072 8 , , , cord-010092-uftc8inx 3072 9 there there EX cord-010092-uftc8inx 3072 10 is be VBZ cord-010092-uftc8inx 3072 11 a a DT cord-010092-uftc8inx 3072 12 need need NN cord-010092-uftc8inx 3072 13 for for IN cord-010092-uftc8inx 3072 14 reliable reliable JJ cord-010092-uftc8inx 3072 15 and and CC cord-010092-uftc8inx 3072 16 accurate accurate JJ cord-010092-uftc8inx 3072 17 automated automate VBN cord-010092-uftc8inx 3072 18 blood blood NN cord-010092-uftc8inx 3072 19 screening screening NN cord-010092-uftc8inx 3072 20 tests test NNS cord-010092-uftc8inx 3072 21 . . . cord-010092-uftc8inx 3073 1 The the DT cord-010092-uftc8inx 3073 2 fully fully RB cord-010092-uftc8inx 3073 3 automated automate VBN cord-010092-uftc8inx 3073 4 cobas cobas NNP cord-010092-uftc8inx 3073 5 e e NN cord-010092-uftc8inx 3073 6 801 801 CD cord-010092-uftc8inx 3073 7 analyser analyser NN cord-010092-uftc8inx 3073 8 can can MD cord-010092-uftc8inx 3073 9 be be VB cord-010092-uftc8inx 3073 10 used use VBN cord-010092-uftc8inx 3073 11 with with IN cord-010092-uftc8inx 3073 12 Elecsys Elecsys NNP cord-010092-uftc8inx 3073 13 â â , cord-010092-uftc8inx 3073 14 infectious infectious JJ cord-010092-uftc8inx 3073 15 disease disease NN cord-010092-uftc8inx 3073 16 parameters parameter NNS cord-010092-uftc8inx 3073 17 to to TO cord-010092-uftc8inx 3073 18 screen screen VB cord-010092-uftc8inx 3073 19 donor donor NN cord-010092-uftc8inx 3073 20 blood blood NN cord-010092-uftc8inx 3073 21 samples sample NNS cord-010092-uftc8inx 3073 22 . . . cord-010092-uftc8inx 3074 1 Aims aim VBZ cord-010092-uftc8inx 3074 2 : : : cord-010092-uftc8inx 3074 3 To to TO cord-010092-uftc8inx 3074 4 compare compare VB cord-010092-uftc8inx 3074 5 the the DT cord-010092-uftc8inx 3074 6 performance performance NN cord-010092-uftc8inx 3074 7 of of IN cord-010092-uftc8inx 3074 8 Elecsys Elecsys NNP cord-010092-uftc8inx 3074 9 â â , cord-010092-uftc8inx 3074 10 infectious infectious JJ cord-010092-uftc8inx 3074 11 disease disease NN cord-010092-uftc8inx 3074 12 parameters parameter NNS cord-010092-uftc8inx 3074 13 on on IN cord-010092-uftc8inx 3074 14 the the DT cord-010092-uftc8inx 3074 15 cobas cobas NNP cord-010092-uftc8inx 3074 16 e e NN cord-010092-uftc8inx 3074 17 801 801 CD cord-010092-uftc8inx 3074 18 analyser analyser NN cord-010092-uftc8inx 3074 19 ( ( -LRB- cord-010092-uftc8inx 3074 20 Roche Roche NNP cord-010092-uftc8inx 3074 21 Diagnostics Diagnostics NNP cord-010092-uftc8inx 3074 22 ) ) -RRB- cord-010092-uftc8inx 3074 23 with with IN cord-010092-uftc8inx 3074 24 other other JJ cord-010092-uftc8inx 3074 25 commercially commercially RB cord-010092-uftc8inx 3074 26 available available JJ cord-010092-uftc8inx 3074 27 assays assay NNS cord-010092-uftc8inx 3074 28 for for IN cord-010092-uftc8inx 3074 29 routine routine JJ cord-010092-uftc8inx 3074 30 first first JJ cord-010092-uftc8inx 3074 31 - - HYPH cord-010092-uftc8inx 3074 32 time time NN cord-010092-uftc8inx 3074 33 blood blood NN cord-010092-uftc8inx 3074 34 donor donor NN cord-010092-uftc8inx 3074 35 screening screening NN cord-010092-uftc8inx 3074 36 . . . cord-010092-uftc8inx 3075 1 Methods method NNS cord-010092-uftc8inx 3075 2 : : : cord-010092-uftc8inx 3075 3 We -PRON- PRP cord-010092-uftc8inx 3075 4 provide provide VBP cord-010092-uftc8inx 3075 5 results result NNS cord-010092-uftc8inx 3075 6 from from IN cord-010092-uftc8inx 3075 7 Etablissement Etablissement NNP cord-010092-uftc8inx 3075 8 Franc Franc NNP cord-010092-uftc8inx 3075 9 ßais ßais NNP cord-010092-uftc8inx 3075 10 du du NNP cord-010092-uftc8inx 3075 11 Sang Sang NNP cord-010092-uftc8inx 3075 12 ( ( -LRB- cord-010092-uftc8inx 3075 13 Montpellier Montpellier NNP cord-010092-uftc8inx 3075 14 ) ) -RRB- cord-010092-uftc8inx 3075 15 , , , cord-010092-uftc8inx 3075 16 a a DT cord-010092-uftc8inx 3075 17 blood blood NN cord-010092-uftc8inx 3075 18 bank bank NN cord-010092-uftc8inx 3075 19 which which WDT cord-010092-uftc8inx 3075 20 participated participate VBD cord-010092-uftc8inx 3075 21 in in IN cord-010092-uftc8inx 3075 22 a a DT cord-010092-uftc8inx 3075 23 large large JJ cord-010092-uftc8inx 3075 24 , , , cord-010092-uftc8inx 3075 25 multicentre multicentre NNP cord-010092-uftc8inx 3075 26 study study NN cord-010092-uftc8inx 3075 27 of of IN cord-010092-uftc8inx 3075 28 the the DT cord-010092-uftc8inx 3075 29 cobas cobas NNP cord-010092-uftc8inx 3075 30 e e NN cord-010092-uftc8inx 3075 31 801 801 CD cord-010092-uftc8inx 3075 32 analyser analyser NN cord-010092-uftc8inx 3075 33 . . . cord-010092-uftc8inx 3076 1 The the DT cord-010092-uftc8inx 3076 2 following follow VBG cord-010092-uftc8inx 3076 3 infectious infectious JJ cord-010092-uftc8inx 3076 4 disease disease NN cord-010092-uftc8inx 3076 5 marker marker NN cord-010092-uftc8inx 3076 6 assays assay NNS cord-010092-uftc8inx 3076 7 were be VBD cord-010092-uftc8inx 3076 8 compared compare VBN cord-010092-uftc8inx 3076 9 : : : cord-010092-uftc8inx 3076 10 HIV HIV NNP cord-010092-uftc8inx 3076 11 , , , cord-010092-uftc8inx 3076 12 Elecsys Elecsys NNP cord-010092-uftc8inx 3076 13 â â LS cord-010092-uftc8inx 3076 14 HIV HIV NNP cord-010092-uftc8inx 3076 15 Duo Duo NNP cord-010092-uftc8inx 3076 16 versus versus IN cord-010092-uftc8inx 3076 17 PRISM prism NN cord-010092-uftc8inx 3077 1 HIV HIV NNP cord-010092-uftc8inx 3077 2 O O NNP cord-010092-uftc8inx 3077 3 Plus Plus NNP cord-010092-uftc8inx 3077 4 ; ; : cord-010092-uftc8inx 3077 5 HCV HCV NNP cord-010092-uftc8inx 3077 6 , , , cord-010092-uftc8inx 3077 7 Elecsys Elecsys NNP cord-010092-uftc8inx 3077 8 â â NNP cord-010092-uftc8inx 3077 9 Anti Anti NNP cord-010092-uftc8inx 3077 10 - - NNP cord-010092-uftc8inx 3077 11 HCV HCV NNP cord-010092-uftc8inx 3077 12 II II NNP cord-010092-uftc8inx 3077 13 versus versus IN cord-010092-uftc8inx 3077 14 PRISM PRISM NNP cord-010092-uftc8inx 3077 15 HCV HCV NNP cord-010092-uftc8inx 3077 16 ; ; : cord-010092-uftc8inx 3077 17 HBV HBV NNP cord-010092-uftc8inx 3077 18 surface surface NN cord-010092-uftc8inx 3077 19 antigen antigen NN cord-010092-uftc8inx 3077 20 ( ( -LRB- cord-010092-uftc8inx 3077 21 HBsAg hbsag ADD cord-010092-uftc8inx 3077 22 ) ) -RRB- cord-010092-uftc8inx 3077 23 , , , cord-010092-uftc8inx 3077 24 Elecsys Elecsys NNP cord-010092-uftc8inx 3077 25 â â NN cord-010092-uftc8inx 3077 26 HBsAg HBsAg NNP cord-010092-uftc8inx 3077 27 II II NNP cord-010092-uftc8inx 3077 28 versus versus IN cord-010092-uftc8inx 3077 29 PRISM prism NN cord-010092-uftc8inx 3077 30 HBsAg hbsag ADD cord-010092-uftc8inx 3077 31 ; ; : cord-010092-uftc8inx 3077 32 HBV HBV NNP cord-010092-uftc8inx 3077 33 core core NN cord-010092-uftc8inx 3077 34 antigen antigen NN cord-010092-uftc8inx 3077 35 antibodies antibody NNS cord-010092-uftc8inx 3077 36 ( ( -LRB- cord-010092-uftc8inx 3077 37 anti anti JJ cord-010092-uftc8inx 3077 38 - - JJ cord-010092-uftc8inx 3077 39 HBc hbc JJ cord-010092-uftc8inx 3077 40 ) ) -RRB- cord-010092-uftc8inx 3077 41 , , , cord-010092-uftc8inx 3077 42 Elecsys Elecsys NNP cord-010092-uftc8inx 3077 43 â â NNP cord-010092-uftc8inx 3077 44 Anti Anti NNP cord-010092-uftc8inx 3077 45 - - JJ cord-010092-uftc8inx 3077 46 HBc HBc NNP cord-010092-uftc8inx 3077 47 II II NNP cord-010092-uftc8inx 3077 48 versus versus IN cord-010092-uftc8inx 3077 49 PRISM PRISM NNP cord-010092-uftc8inx 3077 50 HBcore HBcore NNP cord-010092-uftc8inx 3077 51 ; ; : cord-010092-uftc8inx 3077 52 syphilis syphili NNS cord-010092-uftc8inx 3077 53 , , , cord-010092-uftc8inx 3077 54 Elecsys Elecsys NNP cord-010092-uftc8inx 3077 55 â â , cord-010092-uftc8inx 3077 56 Syphilis Syphilis NNP cord-010092-uftc8inx 3077 57 versus versus IN cord-010092-uftc8inx 3077 58 newbio newbio NNP cord-010092-uftc8inx 3077 59 pk pk NNP cord-010092-uftc8inx 3077 60 TPHA TPHA NNP cord-010092-uftc8inx 3077 61 assay assay NN cord-010092-uftc8inx 3077 62 . . . cord-010092-uftc8inx 3078 1 Specificity specificity NN cord-010092-uftc8inx 3078 2 was be VBD cord-010092-uftc8inx 3078 3 tested test VBN cord-010092-uftc8inx 3078 4 using use VBG cord-010092-uftc8inx 3078 5 residual residual JJ cord-010092-uftc8inx 3078 6 fresh fresh JJ cord-010092-uftc8inx 3078 7 serum serum NN cord-010092-uftc8inx 3078 8 samples sample NNS cord-010092-uftc8inx 3078 9 from from IN cord-010092-uftc8inx 3078 10 unselected unselected JJ cord-010092-uftc8inx 3078 11 first first JJ cord-010092-uftc8inx 3078 12 - - HYPH cord-010092-uftc8inx 3078 13 time time NN cord-010092-uftc8inx 3078 14 blood blood NN cord-010092-uftc8inx 3078 15 donors donor NNS cord-010092-uftc8inx 3078 16 , , , cord-010092-uftc8inx 3078 17 and and CC cord-010092-uftc8inx 3078 18 calculated calculate VBN cord-010092-uftc8inx 3078 19 according accord VBG cord-010092-uftc8inx 3078 20 to to IN cord-010092-uftc8inx 3078 21 assay assay NN cord-010092-uftc8inx 3078 22 package package NN cord-010092-uftc8inx 3078 23 inserts insert NNS cord-010092-uftc8inx 3078 24 and and CC cord-010092-uftc8inx 3078 25 site site NN cord-010092-uftc8inx 3078 26 - - HYPH cord-010092-uftc8inx 3078 27 specific specific JJ cord-010092-uftc8inx 3078 28 cutoffs cutoff NNS cord-010092-uftc8inx 3078 29 . . . cord-010092-uftc8inx 3079 1 Samples sample NNS cord-010092-uftc8inx 3079 2 were be VBD cord-010092-uftc8inx 3079 3 tested test VBN cord-010092-uftc8inx 3079 4 using use VBG cord-010092-uftc8inx 3079 5 comparator comparator NN cord-010092-uftc8inx 3079 6 assays assay NNS cord-010092-uftc8inx 3079 7 , , , cord-010092-uftc8inx 3079 8 then then RB cord-010092-uftc8inx 3079 9 retested reteste VBD cord-010092-uftc8inx 3079 10 the the DT cord-010092-uftc8inx 3079 11 same same JJ cord-010092-uftc8inx 3079 12 day day NN cord-010092-uftc8inx 3079 13 using use VBG cord-010092-uftc8inx 3079 14 Elecsys Elecsys NNP cord-010092-uftc8inx 3079 15 â â , cord-010092-uftc8inx 3079 16 assays assay NNS cord-010092-uftc8inx 3079 17 . . . cord-010092-uftc8inx 3080 1 Initially initially RB cord-010092-uftc8inx 3080 2 reactive reactive JJ cord-010092-uftc8inx 3080 3 samples sample NNS cord-010092-uftc8inx 3080 4 were be VBD cord-010092-uftc8inx 3080 5 repeated repeat VBN cord-010092-uftc8inx 3080 6 in in IN cord-010092-uftc8inx 3080 7 duplicate duplicate JJ cord-010092-uftc8inx 3080 8 ; ; , cord-010092-uftc8inx 3080 9 confirmatory confirmatory JJ cord-010092-uftc8inx 3080 10 tests test NNS cord-010092-uftc8inx 3080 11 were be VBD cord-010092-uftc8inx 3080 12 conducted conduct VBN cord-010092-uftc8inx 3080 13 on on IN cord-010092-uftc8inx 3080 14 repeatedly repeatedly RB cord-010092-uftc8inx 3080 15 reactive reactive JJ cord-010092-uftc8inx 3080 16 samples sample NNS cord-010092-uftc8inx 3080 17 . . . cord-010092-uftc8inx 3081 1 Confirmatory confirmatory JJ cord-010092-uftc8inx 3081 2 tests test NNS cord-010092-uftc8inx 3081 3 : : : cord-010092-uftc8inx 3081 4 HIV HIV NNP cord-010092-uftc8inx 3081 5 , , , cord-010092-uftc8inx 3081 6 nucleic nucleic JJ cord-010092-uftc8inx 3081 7 acid acid NN cord-010092-uftc8inx 3081 8 testing testing NN cord-010092-uftc8inx 3081 9 ( ( -LRB- cord-010092-uftc8inx 3081 10 NAT NAT NNP cord-010092-uftc8inx 3081 11 ) ) -RRB- cord-010092-uftc8inx 3081 12 , , , cord-010092-uftc8inx 3081 13 ARCHITECT ARCHITECT NNP cord-010092-uftc8inx 3081 14 HIV HIV NNP cord-010092-uftc8inx 3081 15 Ag Ag NNP cord-010092-uftc8inx 3081 16 / / SYM cord-010092-uftc8inx 3081 17 Ab Ab NNP cord-010092-uftc8inx 3081 18 and and CC cord-010092-uftc8inx 3081 19 INNO INNO NNP cord-010092-uftc8inx 3081 20 - - HYPH cord-010092-uftc8inx 3081 21 LIA LIA NNP cord-010092-uftc8inx 3082 1 â â LS cord-010092-uftc8inx 3083 1 HIV HIV NNP cord-010092-uftc8inx 3083 2 I I NNP cord-010092-uftc8inx 3083 3 / / SYM cord-010092-uftc8inx 3083 4 II II NNP cord-010092-uftc8inx 3083 5 Score score NN cord-010092-uftc8inx 3083 6 assays assay NNS cord-010092-uftc8inx 3083 7 ; ; : cord-010092-uftc8inx 3083 8 HCV HCV NNP cord-010092-uftc8inx 3083 9 , , , cord-010092-uftc8inx 3083 10 NAT NAT NNP cord-010092-uftc8inx 3083 11 , , , cord-010092-uftc8inx 3083 12 ARCHI ARCHI NNP cord-010092-uftc8inx 3083 13 - - HYPH cord-010092-uftc8inx 3083 14 TECT TECT NNP cord-010092-uftc8inx 3083 15 HCV HCV NNP cord-010092-uftc8inx 3083 16 and and CC cord-010092-uftc8inx 3083 17 INNO INNO NNP cord-010092-uftc8inx 3083 18 - - HYPH cord-010092-uftc8inx 3083 19 LIA LIA NNP cord-010092-uftc8inx 3084 1 â â LS cord-010092-uftc8inx 3085 1 HCV HCV NNP cord-010092-uftc8inx 3085 2 Score Score NNP cord-010092-uftc8inx 3085 3 assays assays RB cord-010092-uftc8inx 3085 4 ; ; : cord-010092-uftc8inx 3085 5 HBsAg hbsag ADD cord-010092-uftc8inx 3085 6 , , , cord-010092-uftc8inx 3085 7 NAT NAT NNP cord-010092-uftc8inx 3085 8 , , , cord-010092-uftc8inx 3085 9 ARCHITECT architect NN cord-010092-uftc8inx 3085 10 HBsAg HBsAg NNP cord-010092-uftc8inx 3085 11 and and CC cord-010092-uftc8inx 3085 12 Elecsys Elecsys NNP cord-010092-uftc8inx 3085 13 â â , cord-010092-uftc8inx 3085 14 /PRISM /PRISM . cord-010092-uftc8inx 3086 1 HBsAg hbsag ADD cord-010092-uftc8inx 3086 2 Confirmatory Confirmatory NNP cord-010092-uftc8inx 3086 3 assays assay NNS cord-010092-uftc8inx 3086 4 ; ; : cord-010092-uftc8inx 3086 5 anti anti JJ cord-010092-uftc8inx 3086 6 - - JJ cord-010092-uftc8inx 3086 7 HBc hbc JJ cord-010092-uftc8inx 3086 8 , , , cord-010092-uftc8inx 3086 9 NAT NAT NNP cord-010092-uftc8inx 3086 10 , , , cord-010092-uftc8inx 3086 11 HBsAg hbsag ADD cord-010092-uftc8inx 3086 12 , , , cord-010092-uftc8inx 3086 13 Anti Anti NNP cord-010092-uftc8inx 3086 14 - - NNP cord-010092-uftc8inx 3086 15 HBs HBs NNP cord-010092-uftc8inx 3086 16 , , , cord-010092-uftc8inx 3086 17 and and CC cord-010092-uftc8inx 3086 18 ARCHITECT ARCHITECT NNP cord-010092-uftc8inx 3086 19 Anti Anti NNP cord-010092-uftc8inx 3086 20 - - JJ cord-010092-uftc8inx 3086 21 HBc hbc JJ cord-010092-uftc8inx 3086 22 assays assay NNS cord-010092-uftc8inx 3086 23 ; ; , cord-010092-uftc8inx 3086 24 syphilis syphili NNS cord-010092-uftc8inx 3086 25 , , , cord-010092-uftc8inx 3086 26 ARCHITECT ARCHITECT NNP cord-010092-uftc8inx 3086 27 Syphilis Syphilis NNP cord-010092-uftc8inx 3086 28 TP TP NNP cord-010092-uftc8inx 3086 29 and and CC cord-010092-uftc8inx 3086 30 INNO INNO NNP cord-010092-uftc8inx 3086 31 - - HYPH cord-010092-uftc8inx 3086 32 LIA LIA NNP cord-010092-uftc8inx 3086 33 â â , cord-010092-uftc8inx 3086 34 Syphilis Syphilis NNP cord-010092-uftc8inx 3086 35 Score score NN cord-010092-uftc8inx 3086 36 assays assay NNS cord-010092-uftc8inx 3086 37 . . . cord-010092-uftc8inx 3087 1 Sensitivity sensitivity NN cord-010092-uftc8inx 3087 2 was be VBD cord-010092-uftc8inx 3087 3 tested test VBN cord-010092-uftc8inx 3087 4 using use VBG cord-010092-uftc8inx 3087 5 30 30 CD cord-010092-uftc8inx 3087 6 preselected preselecte VBN cord-010092-uftc8inx 3087 7 , , , cord-010092-uftc8inx 3087 8 anonymised anonymised JJ cord-010092-uftc8inx 3087 9 , , , cord-010092-uftc8inx 3087 10 positive positive JJ cord-010092-uftc8inx 3087 11 , , , cord-010092-uftc8inx 3087 12 citrate citrate NN cord-010092-uftc8inx 3087 13 - - HYPH cord-010092-uftc8inx 3087 14 phosphate phosphate NN cord-010092-uftc8inx 3087 15 - - HYPH cord-010092-uftc8inx 3087 16 dextrose dextrose NN cord-010092-uftc8inx 3087 17 - - HYPH cord-010092-uftc8inx 3087 18 plasma plasma NN cord-010092-uftc8inx 3087 19 samples sample NNS cord-010092-uftc8inx 3087 20 ( ( -LRB- cord-010092-uftc8inx 3087 21 Plasmatec Plasmatec NNP cord-010092-uftc8inx 3087 22 Laboratory Laboratory NNP cord-010092-uftc8inx 3087 23 Products Products NNPS cord-010092-uftc8inx 3087 24 ) ) -RRB- cord-010092-uftc8inx 3087 25 and and CC cord-010092-uftc8inx 3087 26 compared compare VBN cord-010092-uftc8inx 3087 27 with with IN cord-010092-uftc8inx 3087 28 archived archived JJ cord-010092-uftc8inx 3087 29 data datum NNS cord-010092-uftc8inx 3087 30 for for IN cord-010092-uftc8inx 3087 31 comparator comparator NN cord-010092-uftc8inx 3087 32 assays assay NNS cord-010092-uftc8inx 3087 33 . . . cord-010092-uftc8inx 3088 1 Sensitivity sensitivity NN cord-010092-uftc8inx 3088 2 was be VBD cord-010092-uftc8inx 3088 3 calculated calculate VBN cord-010092-uftc8inx 3088 4 according accord VBG cord-010092-uftc8inx 3088 5 to to IN cord-010092-uftc8inx 3088 6 the the DT cord-010092-uftc8inx 3088 7 final final JJ cord-010092-uftc8inx 3088 8 NAT NAT NNP cord-010092-uftc8inx 3088 9 result result NN cord-010092-uftc8inx 3088 10 . . . cord-010092-uftc8inx 3089 1 Results result NNS cord-010092-uftc8inx 3089 2 : : : cord-010092-uftc8inx 3090 1 Across across IN cord-010092-uftc8inx 3090 2 all all DT cord-010092-uftc8inx 3090 3 infectious infectious JJ cord-010092-uftc8inx 3090 4 disease disease NN cord-010092-uftc8inx 3090 5 markers marker NNS cord-010092-uftc8inx 3090 6 , , , cord-010092-uftc8inx 3090 7 specificity specificity NN cord-010092-uftc8inx 3090 8 to to TO cord-010092-uftc8inx 3090 9 detect detect VB cord-010092-uftc8inx 3090 10 repeatedly repeatedly RB cord-010092-uftc8inx 3090 11 reactive reactive JJ cord-010092-uftc8inx 3090 12 samples sample NNS cord-010092-uftc8inx 3090 13 using use VBG cord-010092-uftc8inx 3090 14 Elecsys Elecsys NNP cord-010092-uftc8inx 3090 15 â â , cord-010092-uftc8inx 3090 16 versus versus IN cord-010092-uftc8inx 3090 17 comparator comparator NN cord-010092-uftc8inx 3090 18 assays assay NNS cord-010092-uftc8inx 3090 19 was be VBD cord-010092-uftc8inx 3090 20 similar similar JJ cord-010092-uftc8inx 3090 21 ( ( -LRB- cord-010092-uftc8inx 3090 22 99.81 99.81 CD cord-010092-uftc8inx 3090 23 - - SYM cord-010092-uftc8inx 3090 24 100.00 100.00 CD cord-010092-uftc8inx 3090 25 % % NN cord-010092-uftc8inx 3090 26 versus versus IN cord-010092-uftc8inx 3090 27 99.79 99.79 CD cord-010092-uftc8inx 3090 28 - - : cord-010092-uftc8inx 3090 29 99.98 99.98 CD cord-010092-uftc8inx 3090 30 % % NN cord-010092-uftc8inx 3090 31 ; ; : cord-010092-uftc8inx 3090 32 n n NN cord-010092-uftc8inx 3090 33 ≥ ≥ CD cord-010092-uftc8inx 3090 34 5195 5195 CD cord-010092-uftc8inx 3090 35 ) ) -RRB- cord-010092-uftc8inx 3090 36 . . . cord-010092-uftc8inx 3091 1 In in IN cord-010092-uftc8inx 3091 2 specificity specificity NN cord-010092-uftc8inx 3091 3 analyses analysis NNS cord-010092-uftc8inx 3091 4 , , , cord-010092-uftc8inx 3091 5 there there EX cord-010092-uftc8inx 3091 6 were be VBD cord-010092-uftc8inx 3091 7 14 14 CD cord-010092-uftc8inx 3091 8 discrepant discrepant JJ cord-010092-uftc8inx 3091 9 results result NNS cord-010092-uftc8inx 3091 10 for for IN cord-010092-uftc8inx 3091 11 HIV HIV NNP cord-010092-uftc8inx 3091 12 testing testing NN cord-010092-uftc8inx 3091 13 , , , cord-010092-uftc8inx 3091 14 27 27 CD cord-010092-uftc8inx 3091 15 for for IN cord-010092-uftc8inx 3091 16 HCV HCV NNP cord-010092-uftc8inx 3091 17 , , , cord-010092-uftc8inx 3091 18 two two CD cord-010092-uftc8inx 3091 19 for for IN cord-010092-uftc8inx 3091 20 HBsAg hbsag ADD cord-010092-uftc8inx 3091 21 , , , cord-010092-uftc8inx 3091 22 eight eight CD cord-010092-uftc8inx 3091 23 for for IN cord-010092-uftc8inx 3091 24 anti anti JJ cord-010092-uftc8inx 3091 25 - - JJ cord-010092-uftc8inx 3091 26 HBc hbc JJ cord-010092-uftc8inx 3091 27 , , , cord-010092-uftc8inx 3091 28 and and CC cord-010092-uftc8inx 3091 29 five five CD cord-010092-uftc8inx 3091 30 for for IN cord-010092-uftc8inx 3091 31 syphilis syphili NNS cord-010092-uftc8inx 3091 32 . . . cord-010092-uftc8inx 3092 1 Sensitivity sensitivity NN cord-010092-uftc8inx 3092 2 of of IN cord-010092-uftc8inx 3092 3 the the DT cord-010092-uftc8inx 3092 4 Elecsys Elecsys NNP cord-010092-uftc8inx 3092 5 â â SYM cord-010092-uftc8inx 3092 6 HIV HIV NNP cord-010092-uftc8inx 3092 7 Duo Duo NNP cord-010092-uftc8inx 3092 8 assay assay NN cord-010092-uftc8inx 3092 9 ( ( -LRB- cord-010092-uftc8inx 3092 10 83.33 83.33 CD cord-010092-uftc8inx 3092 11 % % NN cord-010092-uftc8inx 3092 12 ; ; : cord-010092-uftc8inx 3092 13 95 95 CD cord-010092-uftc8inx 3092 14 % % NN cord-010092-uftc8inx 3092 15 CI CI NNP cord-010092-uftc8inx 3092 16 65 65 CD cord-010092-uftc8inx 3092 17 . . . cord-010092-uftc8inx 3093 1 28 28 CD cord-010092-uftc8inx 3093 2 - - SYM cord-010092-uftc8inx 3093 3 94.36 94.36 CD cord-010092-uftc8inx 3093 4 ) ) -RRB- cord-010092-uftc8inx 3093 5 was be VBD cord-010092-uftc8inx 3093 6 higher high JJR cord-010092-uftc8inx 3093 7 than than IN cord-010092-uftc8inx 3093 8 the the DT cord-010092-uftc8inx 3093 9 PRISM prism NN cord-010092-uftc8inx 3094 1 HIV HIV NNP cord-010092-uftc8inx 3094 2 O O NNP cord-010092-uftc8inx 3094 3 Plus Plus NNP cord-010092-uftc8inx 3094 4 assay assay NN cord-010092-uftc8inx 3094 5 ( ( -LRB- cord-010092-uftc8inx 3094 6 76.67 76.67 CD cord-010092-uftc8inx 3094 7 % % NN cord-010092-uftc8inx 3094 8 ; ; : cord-010092-uftc8inx 3094 9 95 95 CD cord-010092-uftc8inx 3094 10 % % NN cord-010092-uftc8inx 3094 11 CI CI NNP cord-010092-uftc8inx 3094 12 57.72 57.72 CD cord-010092-uftc8inx 3094 13 - - SYM cord-010092-uftc8inx 3094 14 90.07 90.07 CD cord-010092-uftc8inx 3094 15 ) ) -RRB- cord-010092-uftc8inx 3094 16 , , , cord-010092-uftc8inx 3094 17 but but CC cord-010092-uftc8inx 3094 18 the the DT cord-010092-uftc8inx 3094 19 difference difference NN cord-010092-uftc8inx 3094 20 was be VBD cord-010092-uftc8inx 3094 21 not not RB cord-010092-uftc8inx 3094 22 statistically statistically RB cord-010092-uftc8inx 3094 23 significant significant JJ cord-010092-uftc8inx 3094 24 . . . cord-010092-uftc8inx 3095 1 Sensitivities sensitivity NNS cord-010092-uftc8inx 3095 2 of of IN cord-010092-uftc8inx 3095 3 Elecsys Elecsys NNP cord-010092-uftc8inx 3095 4 â â , cord-010092-uftc8inx 3095 5 and and CC cord-010092-uftc8inx 3095 6 comparator comparator NN cord-010092-uftc8inx 3095 7 assays assay NNS cord-010092-uftc8inx 3095 8 were be VBD cord-010092-uftc8inx 3095 9 the the DT cord-010092-uftc8inx 3095 10 same same JJ cord-010092-uftc8inx 3095 11 for for IN cord-010092-uftc8inx 3095 12 HCV HCV NNP cord-010092-uftc8inx 3095 13 ( ( -LRB- cord-010092-uftc8inx 3095 14 85.19 85.19 CD cord-010092-uftc8inx 3095 15 % % NN cord-010092-uftc8inx 3095 16 ; ; : cord-010092-uftc8inx 3095 17 95 95 CD cord-010092-uftc8inx 3095 18 % % NN cord-010092-uftc8inx 3095 19 CI CI NNP cord-010092-uftc8inx 3095 20 67.33 67.33 CD cord-010092-uftc8inx 3095 21 - - SYM cord-010092-uftc8inx 3095 22 95.97 95.97 CD cord-010092-uftc8inx 3095 23 ) ) -RRB- cord-010092-uftc8inx 3095 24 , , , cord-010092-uftc8inx 3095 25 HBsAg HBsAg NNP cord-010092-uftc8inx 3095 26 ( ( -LRB- cord-010092-uftc8inx 3095 27 70.00 70.00 CD cord-010092-uftc8inx 3095 28 % % NN cord-010092-uftc8inx 3095 29 ; ; : cord-010092-uftc8inx 3095 30 95 95 CD cord-010092-uftc8inx 3095 31 % % NN cord-010092-uftc8inx 3095 32 CI CI NNP cord-010092-uftc8inx 3095 33 50.60 50.60 CD cord-010092-uftc8inx 3095 34 - - HYPH cord-010092-uftc8inx 3095 35 85.27 85.27 CD cord-010092-uftc8inx 3095 36 ) ) -RRB- cord-010092-uftc8inx 3095 37 , , , cord-010092-uftc8inx 3095 38 anti anti JJ cord-010092-uftc8inx 3095 39 - - JJ cord-010092-uftc8inx 3095 40 HBc hbc JJ cord-010092-uftc8inx 3095 41 ( ( -LRB- cord-010092-uftc8inx 3095 42 100.00 100.00 CD cord-010092-uftc8inx 3095 43 % % NN cord-010092-uftc8inx 3095 44 ; ; : cord-010092-uftc8inx 3095 45 95 95 CD cord-010092-uftc8inx 3095 46 % % NN cord-010092-uftc8inx 3095 47 CI CI NNP cord-010092-uftc8inx 3095 48 85.75 85.75 CD cord-010092-uftc8inx 3095 49 - - HYPH cord-010092-uftc8inx 3095 50 100.00 100.00 CD cord-010092-uftc8inx 3095 51 ) ) -RRB- cord-010092-uftc8inx 3095 52 , , , cord-010092-uftc8inx 3095 53 and and CC cord-010092-uftc8inx 3095 54 syphilis syphili NNS cord-010092-uftc8inx 3095 55 ( ( -LRB- cord-010092-uftc8inx 3095 56 100.00 100.00 CD cord-010092-uftc8inx 3095 57 % % NN cord-010092-uftc8inx 3095 58 ; ; : cord-010092-uftc8inx 3095 59 95 95 CD cord-010092-uftc8inx 3095 60 % % NN cord-010092-uftc8inx 3095 61 CI CI NNP cord-010092-uftc8inx 3095 62 88.43 88.43 CD cord-010092-uftc8inx 3095 63 - - HYPH cord-010092-uftc8inx 3095 64 100.00 100.00 CD cord-010092-uftc8inx 3095 65 ) ) -RRB- cord-010092-uftc8inx 3095 66 ; ; : cord-010092-uftc8inx 3095 67 three three CD cord-010092-uftc8inx 3095 68 HCV HCV NNP cord-010092-uftc8inx 3095 69 and and CC cord-010092-uftc8inx 3095 70 six six CD cord-010092-uftc8inx 3095 71 anti anti JJ cord-010092-uftc8inx 3095 72 - - JJ cord-010092-uftc8inx 3095 73 HBc hbc JJ cord-010092-uftc8inx 3095 74 samples sample NNS cord-010092-uftc8inx 3095 75 were be VBD cord-010092-uftc8inx 3095 76 classified classify VBN cord-010092-uftc8inx 3095 77 negative/ negative/ CD cord-010092-uftc8inx 3095 78 indeterminate indeterminate JJ cord-010092-uftc8inx 3095 79 and and CC cord-010092-uftc8inx 3095 80 excluded exclude VBN cord-010092-uftc8inx 3095 81 from from IN cord-010092-uftc8inx 3095 82 the the DT cord-010092-uftc8inx 3095 83 analyses analysis NNS cord-010092-uftc8inx 3095 84 . . . cord-010092-uftc8inx 3096 1 In in IN cord-010092-uftc8inx 3096 2 sensitivity sensitivity NN cord-010092-uftc8inx 3096 3 analyses analysis NNS cord-010092-uftc8inx 3096 4 , , , cord-010092-uftc8inx 3096 5 there there EX cord-010092-uftc8inx 3096 6 were be VBD cord-010092-uftc8inx 3096 7 two two CD cord-010092-uftc8inx 3096 8 discrepant discrepant JJ cord-010092-uftc8inx 3096 9 results result NNS cord-010092-uftc8inx 3096 10 for for IN cord-010092-uftc8inx 3096 11 HIV HIV NNP cord-010092-uftc8inx 3096 12 testing testing NN cord-010092-uftc8inx 3096 13 , , , cord-010092-uftc8inx 3096 14 three three CD cord-010092-uftc8inx 3096 15 for for IN cord-010092-uftc8inx 3096 16 HCV HCV NNP cord-010092-uftc8inx 3096 17 , , , cord-010092-uftc8inx 3096 18 and and CC cord-010092-uftc8inx 3096 19 five five CD cord-010092-uftc8inx 3096 20 for for IN cord-010092-uftc8inx 3096 21 anti anti JJ cord-010092-uftc8inx 3096 22 - - JJ cord-010092-uftc8inx 3096 23 HBc HBc NNS cord-010092-uftc8inx 3096 24 . . . cord-010092-uftc8inx 3097 1 Summary Summary NNP cord-010092-uftc8inx 3097 2 / / SYM cord-010092-uftc8inx 3097 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 3097 4 : : : cord-010092-uftc8inx 3098 1 Elecsys elecsys NN cord-010092-uftc8inx 3098 2 â â LS cord-010092-uftc8inx 3098 3 infectious infectious JJ cord-010092-uftc8inx 3098 4 disease disease NN cord-010092-uftc8inx 3098 5 parameters parameter NNS cord-010092-uftc8inx 3098 6 on on IN cord-010092-uftc8inx 3098 7 the the DT cord-010092-uftc8inx 3098 8 cobas cobas NNP cord-010092-uftc8inx 3098 9 e e NN cord-010092-uftc8inx 3098 10 801 801 CD cord-010092-uftc8inx 3098 11 analyser analyser NN cord-010092-uftc8inx 3098 12 demonstrate demonstrate VBP cord-010092-uftc8inx 3098 13 high high JJ cord-010092-uftc8inx 3098 14 specificity specificity NN cord-010092-uftc8inx 3098 15 / / SYM cord-010092-uftc8inx 3098 16 sensitivity sensitivity NN cord-010092-uftc8inx 3098 17 for for IN cord-010092-uftc8inx 3098 18 screening screen VBG cord-010092-uftc8inx 3098 19 first first JJ cord-010092-uftc8inx 3098 20 - - HYPH cord-010092-uftc8inx 3098 21 time time NN cord-010092-uftc8inx 3098 22 blood blood NN cord-010092-uftc8inx 3098 23 donor donor NN cord-010092-uftc8inx 3098 24 samples sample NNS cord-010092-uftc8inx 3098 25 , , , cord-010092-uftc8inx 3098 26 with with IN cord-010092-uftc8inx 3098 27 similar similar JJ cord-010092-uftc8inx 3098 28 clinical clinical JJ cord-010092-uftc8inx 3098 29 performance performance NN cord-010092-uftc8inx 3098 30 to to IN cord-010092-uftc8inx 3098 31 other other JJ cord-010092-uftc8inx 3098 32 commercially commercially RB cord-010092-uftc8inx 3098 33 available available JJ cord-010092-uftc8inx 3098 34 assays assay NNS cord-010092-uftc8inx 3098 35 . . . cord-010092-uftc8inx 3099 1 Background background NN cord-010092-uftc8inx 3099 2 : : : cord-010092-uftc8inx 3100 1 Individual individual JJ cord-010092-uftc8inx 3100 2 plasma plasma NN cord-010092-uftc8inx 3100 3 and and CC cord-010092-uftc8inx 3100 4 serum serum NN cord-010092-uftc8inx 3100 5 specimens specimen NNS cord-010092-uftc8inx 3100 6 from from IN cord-010092-uftc8inx 3100 7 whole whole JJ cord-010092-uftc8inx 3100 8 blood blood NN cord-010092-uftc8inx 3100 9 or or CC cord-010092-uftc8inx 3100 10 plasmapheresis plasmapheresis NN cord-010092-uftc8inx 3100 11 donors donor NNS cord-010092-uftc8inx 3100 12 are be VBP cord-010092-uftc8inx 3100 13 tested test VBN cord-010092-uftc8inx 3100 14 for for IN cord-010092-uftc8inx 3100 15 absence absence NN cord-010092-uftc8inx 3100 16 of of IN cord-010092-uftc8inx 3100 17 infectious infectious JJ cord-010092-uftc8inx 3100 18 agents agent NNS cord-010092-uftc8inx 3100 19 by by IN cord-010092-uftc8inx 3100 20 serological serological JJ cord-010092-uftc8inx 3100 21 assays assay NNS cord-010092-uftc8inx 3100 22 prior prior RB cord-010092-uftc8inx 3100 23 to to IN cord-010092-uftc8inx 3100 24 use use NN cord-010092-uftc8inx 3100 25 for for IN cord-010092-uftc8inx 3100 26 transfusion transfusion NN cord-010092-uftc8inx 3100 27 or or CC cord-010092-uftc8inx 3100 28 production production NN cord-010092-uftc8inx 3100 29 of of IN cord-010092-uftc8inx 3100 30 blood blood NN cord-010092-uftc8inx 3100 31 derived derive VBN cord-010092-uftc8inx 3100 32 therapeutics therapeutic NNS cord-010092-uftc8inx 3100 33 . . . cord-010092-uftc8inx 3101 1 The the DT cord-010092-uftc8inx 3101 2 Department Department NNP cord-010092-uftc8inx 3101 3 of of IN cord-010092-uftc8inx 3101 4 Plasma Plasma NNP cord-010092-uftc8inx 3101 5 Analytics Analytics NNP cord-010092-uftc8inx 3101 6 ( ( -LRB- cord-010092-uftc8inx 3101 7 PA PA NNP cord-010092-uftc8inx 3101 8 ) ) -RRB- cord-010092-uftc8inx 3101 9 , , , cord-010092-uftc8inx 3101 10 Takeda Takeda NNP cord-010092-uftc8inx 3101 11 ( ( -LRB- cord-010092-uftc8inx 3101 12 Austria Austria NNP cord-010092-uftc8inx 3101 13 ) ) -RRB- cord-010092-uftc8inx 3101 14 , , , cord-010092-uftc8inx 3101 15 and and CC cord-010092-uftc8inx 3101 16 Haema Haema NNP cord-010092-uftc8inx 3101 17 AG AG NNP cord-010092-uftc8inx 3101 18 , , , cord-010092-uftc8inx 3101 19 Grifols Grifols NNP cord-010092-uftc8inx 3101 20 ( ( -LRB- cord-010092-uftc8inx 3101 21 Germany Germany NNP cord-010092-uftc8inx 3101 22 ) ) -RRB- cord-010092-uftc8inx 3101 23 , , , cord-010092-uftc8inx 3101 24 both both DT cord-010092-uftc8inx 3101 25 labs lab NNS cord-010092-uftc8inx 3101 26 with with IN cord-010092-uftc8inx 3101 27 high high JJ cord-010092-uftc8inx 3101 28 throughput throughput NN cord-010092-uftc8inx 3101 29 and and CC cord-010092-uftc8inx 3101 30 a a DT cord-010092-uftc8inx 3101 31 high high JJ cord-010092-uftc8inx 3101 32 level level NN cord-010092-uftc8inx 3101 33 of of IN cord-010092-uftc8inx 3101 34 automation automation NN cord-010092-uftc8inx 3101 35 , , , cord-010092-uftc8inx 3101 36 were be VBD cord-010092-uftc8inx 3101 37 seeking seek VBG cord-010092-uftc8inx 3101 38 for for IN cord-010092-uftc8inx 3101 39 alternatives alternative NNS cord-010092-uftc8inx 3101 40 to to TO cord-010092-uftc8inx 3101 41 replace replace VB cord-010092-uftc8inx 3101 42 their -PRON- PRP$ cord-010092-uftc8inx 3101 43 current current JJ cord-010092-uftc8inx 3101 44 serological serological JJ cord-010092-uftc8inx 3101 45 test test NN cord-010092-uftc8inx 3101 46 systems system NNS cord-010092-uftc8inx 3101 47 ( ( -LRB- cord-010092-uftc8inx 3101 48 Abbott Abbott NNP cord-010092-uftc8inx 3101 49 PRISM PRISM NNP cord-010092-uftc8inx 3101 50 Next Next NNP cord-010092-uftc8inx 3101 51 ) ) -RRB- cord-010092-uftc8inx 3101 52 . . . cord-010092-uftc8inx 3102 1 Aims aim VBZ cord-010092-uftc8inx 3102 2 : : : cord-010092-uftc8inx 3103 1 To to TO cord-010092-uftc8inx 3103 2 allow allow VB cord-010092-uftc8inx 3103 3 a a DT cord-010092-uftc8inx 3103 4 direct direct JJ cord-010092-uftc8inx 3103 5 comparison comparison NN cord-010092-uftc8inx 3103 6 of of IN cord-010092-uftc8inx 3103 7 the the DT cord-010092-uftc8inx 3103 8 two two CD cord-010092-uftc8inx 3103 9 final final JJ cord-010092-uftc8inx 3103 10 candidate candidate NN cord-010092-uftc8inx 3103 11 analyzers analyzer VBZ cord-010092-uftc8inx 3103 12 Alinity Alinity NNP cord-010092-uftc8inx 3103 13 s s POS cord-010092-uftc8inx 3103 14 ( ( -LRB- cord-010092-uftc8inx 3103 15 Abbott Abbott NNP cord-010092-uftc8inx 3103 16 ) ) -RRB- cord-010092-uftc8inx 3103 17 and and CC cord-010092-uftc8inx 3103 18 cobas cobas NNP cord-010092-uftc8inx 3103 19 e801 e801 NNS cord-010092-uftc8inx 3104 1 ( ( -LRB- cord-010092-uftc8inx 3104 2 Roche Roche NNP cord-010092-uftc8inx 3104 3 Diagnostics Diagnostics NNP cord-010092-uftc8inx 3104 4 GmbH GmbH NNP cord-010092-uftc8inx 3104 5 ) ) -RRB- cord-010092-uftc8inx 3104 6 , , , cord-010092-uftc8inx 3104 7 a a DT cord-010092-uftc8inx 3104 8 side side NN cord-010092-uftc8inx 3104 9 by by IN cord-010092-uftc8inx 3104 10 side side NN cord-010092-uftc8inx 3104 11 evaluation evaluation NN cord-010092-uftc8inx 3104 12 was be VBD cord-010092-uftc8inx 3104 13 carried carry VBN cord-010092-uftc8inx 3104 14 out out RP cord-010092-uftc8inx 3104 15 by by IN cord-010092-uftc8inx 3104 16 the the DT cord-010092-uftc8inx 3104 17 PA PA NNP cord-010092-uftc8inx 3104 18 and and CC cord-010092-uftc8inx 3104 19 Haema Haema NNP cord-010092-uftc8inx 3104 20 with with IN cord-010092-uftc8inx 3104 21 support support NN cord-010092-uftc8inx 3104 22 from from IN cord-010092-uftc8inx 3104 23 Abbott Abbott NNP cord-010092-uftc8inx 3104 24 and and CC cord-010092-uftc8inx 3104 25 Roche Roche NNP cord-010092-uftc8inx 3104 26 ( ( -LRB- cord-010092-uftc8inx 3104 27 provision provision NN cord-010092-uftc8inx 3104 28 of of IN cord-010092-uftc8inx 3104 29 instruments instrument NNS cord-010092-uftc8inx 3104 30 and and CC cord-010092-uftc8inx 3104 31 reagents reagent NNS cord-010092-uftc8inx 3104 32 ) ) -RRB- cord-010092-uftc8inx 3104 33 . . . cord-010092-uftc8inx 3105 1 The the DT cord-010092-uftc8inx 3105 2 aim aim NN cord-010092-uftc8inx 3105 3 was be VBD cord-010092-uftc8inx 3105 4 to to TO cord-010092-uftc8inx 3105 5 compare compare VB cord-010092-uftc8inx 3105 6 assay assay NN cord-010092-uftc8inx 3105 7 specificities specificity NNS cord-010092-uftc8inx 3105 8 as as RB cord-010092-uftc8inx 3105 9 well well RB cord-010092-uftc8inx 3105 10 as as IN cord-010092-uftc8inx 3105 11 handling handling NN cord-010092-uftc8inx 3105 12 and and CC cord-010092-uftc8inx 3105 13 performance performance NN cord-010092-uftc8inx 3105 14 of of IN cord-010092-uftc8inx 3105 15 the the DT cord-010092-uftc8inx 3105 16 instruments instrument NNS cord-010092-uftc8inx 3105 17 . . . cord-010092-uftc8inx 3106 1 The the DT cord-010092-uftc8inx 3106 2 outcome outcome NN cord-010092-uftc8inx 3106 3 should should MD cord-010092-uftc8inx 3106 4 be be VB cord-010092-uftc8inx 3106 5 used use VBN cord-010092-uftc8inx 3106 6 to to TO cord-010092-uftc8inx 3106 7 better well RBR cord-010092-uftc8inx 3106 8 understand understand VB cord-010092-uftc8inx 3106 9 potential potential JJ cord-010092-uftc8inx 3106 10 specificity specificity NN cord-010092-uftc8inx 3106 11 differences difference NNS cord-010092-uftc8inx 3106 12 and and CC cord-010092-uftc8inx 3106 13 practical practical JJ cord-010092-uftc8inx 3106 14 handling handling NN cord-010092-uftc8inx 3106 15 aspects aspect NNS cord-010092-uftc8inx 3106 16 ( ( -LRB- cord-010092-uftc8inx 3106 17 throughput throughput NN cord-010092-uftc8inx 3106 18 , , , cord-010092-uftc8inx 3106 19 etc etc FW cord-010092-uftc8inx 3106 20 . . . cord-010092-uftc8inx 3106 21 ) ) -RRB- cord-010092-uftc8inx 3107 1 of of IN cord-010092-uftc8inx 3107 2 a a DT cord-010092-uftc8inx 3107 3 next next JJ cord-010092-uftc8inx 3107 4 generation generation NN cord-010092-uftc8inx 3107 5 serological serological JJ cord-010092-uftc8inx 3107 6 analyzer analyzer NN cord-010092-uftc8inx 3107 7 . . . cord-010092-uftc8inx 3108 1 Methods method NNS cord-010092-uftc8inx 3108 2 : : : cord-010092-uftc8inx 3109 1 The the DT cord-010092-uftc8inx 3109 2 two two CD cord-010092-uftc8inx 3109 3 candidate candidate NN cord-010092-uftc8inx 3109 4 instruments instrument NNS cord-010092-uftc8inx 3109 5 were be VBD cord-010092-uftc8inx 3109 6 installed instal VBN cord-010092-uftc8inx 3109 7 in in IN cord-010092-uftc8inx 3109 8 the the DT cord-010092-uftc8inx 3109 9 PA PA NNP cord-010092-uftc8inx 3109 10 . . . cord-010092-uftc8inx 3110 1 From from IN cord-010092-uftc8inx 3110 2 March March NNP cord-010092-uftc8inx 3110 3 to to IN cord-010092-uftc8inx 3110 4 June June NNP cord-010092-uftc8inx 3110 5 2018 2018 CD cord-010092-uftc8inx 3110 6 , , , cord-010092-uftc8inx 3110 7 close close JJ cord-010092-uftc8inx 3110 8 to to IN cord-010092-uftc8inx 3110 9 10,000 10,000 CD cord-010092-uftc8inx 3110 10 aliquots aliquot NNS cord-010092-uftc8inx 3110 11 from from IN cord-010092-uftc8inx 3110 12 routine routine JJ cord-010092-uftc8inx 3110 13 preselected preselecte VBN cord-010092-uftc8inx 3110 14 repeat repeat NN cord-010092-uftc8inx 3110 15 donors donor NNS cord-010092-uftc8inx 3110 16 , , , cord-010092-uftc8inx 3110 17 provided provide VBN cord-010092-uftc8inx 3110 18 by by IN cord-010092-uftc8inx 3110 19 Haema Haema NNP cord-010092-uftc8inx 3110 20 , , , cord-010092-uftc8inx 3110 21 were be VBD cord-010092-uftc8inx 3110 22 run run VBN cord-010092-uftc8inx 3110 23 on on IN cord-010092-uftc8inx 3110 24 both both DT cord-010092-uftc8inx 3110 25 study study NN cord-010092-uftc8inx 3110 26 instruments instrument NNS cord-010092-uftc8inx 3110 27 in in IN cord-010092-uftc8inx 3110 28 parallel parallel NN cord-010092-uftc8inx 3110 29 . . . cord-010092-uftc8inx 3111 1 Plasma plasma NN cord-010092-uftc8inx 3111 2 samples sample NNS cord-010092-uftc8inx 3111 3 were be VBD cord-010092-uftc8inx 3111 4 tested test VBN cord-010092-uftc8inx 3111 5 for for IN cord-010092-uftc8inx 3111 6 HBs HBs NNP cord-010092-uftc8inx 3111 7 antigen antigen NNP cord-010092-uftc8inx 3111 8 ( ( -LRB- cord-010092-uftc8inx 3111 9 Ag Ag NNP cord-010092-uftc8inx 3111 10 ) ) -RRB- cord-010092-uftc8inx 3111 11 , , , cord-010092-uftc8inx 3111 12 HCV HCV NNP cord-010092-uftc8inx 3111 13 antibody antibody NN cord-010092-uftc8inx 3111 14 ( ( -LRB- cord-010092-uftc8inx 3111 15 Ab Ab NNP cord-010092-uftc8inx 3111 16 ) ) -RRB- cord-010092-uftc8inx 3111 17 , , , cord-010092-uftc8inx 3111 18 HIV HIV NNP cord-010092-uftc8inx 3111 19 Ag Ag NNP cord-010092-uftc8inx 3111 20 / / SYM cord-010092-uftc8inx 3111 21 Ab Ab NNP cord-010092-uftc8inx 3111 22 , , , cord-010092-uftc8inx 3111 23 and and CC cord-010092-uftc8inx 3111 24 partially partially RB cord-010092-uftc8inx 3111 25 for for IN cord-010092-uftc8inx 3111 26 Syphilis Syphilis NNP cord-010092-uftc8inx 3111 27 Ab Ab NNP cord-010092-uftc8inx 3111 28 . . . cord-010092-uftc8inx 3112 1 Serum serum NN cord-010092-uftc8inx 3112 2 samples sample NNS cord-010092-uftc8inx 3112 3 were be VBD cord-010092-uftc8inx 3112 4 additionally additionally RB cord-010092-uftc8inx 3112 5 tested test VBN cord-010092-uftc8inx 3112 6 on on IN cord-010092-uftc8inx 3112 7 HBc HBc NNP cord-010092-uftc8inx 3112 8 Ab Ab NNP cord-010092-uftc8inx 3112 9 . . . cord-010092-uftc8inx 3113 1 Samples sample NNS cord-010092-uftc8inx 3113 2 with with IN cord-010092-uftc8inx 3113 3 repeat repeat NN cord-010092-uftc8inx 3113 4 reactive reactive JJ cord-010092-uftc8inx 3113 5 results result NNS cord-010092-uftc8inx 3113 6 ( ( -LRB- cord-010092-uftc8inx 3113 7 " " `` cord-010092-uftc8inx 3113 8 RR RR NNP cord-010092-uftc8inx 3113 9 " " '' cord-010092-uftc8inx 3113 10 , , , cord-010092-uftc8inx 3113 11 two two CD cord-010092-uftc8inx 3113 12 reactive reactive JJ cord-010092-uftc8inx 3113 13 results result NNS cord-010092-uftc8inx 3113 14 out out IN cord-010092-uftc8inx 3113 15 of of IN cord-010092-uftc8inx 3113 16 three three CD cord-010092-uftc8inx 3113 17 tests test NNS cord-010092-uftc8inx 3113 18 ) ) -RRB- cord-010092-uftc8inx 3114 1 not not RB cord-010092-uftc8inx 3114 2 confirmed confirm VBN cord-010092-uftc8inx 3114 3 by by IN cord-010092-uftc8inx 3114 4 confirmatory confirmatory JJ cord-010092-uftc8inx 3114 5 tests test NNS cord-010092-uftc8inx 3114 6 were be VBD cord-010092-uftc8inx 3114 7 counted count VBN cord-010092-uftc8inx 3114 8 as as IN cord-010092-uftc8inx 3114 9 false false JJ cord-010092-uftc8inx 3114 10 reactive reactive JJ cord-010092-uftc8inx 3114 11 . . . cord-010092-uftc8inx 3115 1 The the DT cord-010092-uftc8inx 3115 2 necessary necessary JJ cord-010092-uftc8inx 3115 3 sample sample NN cord-010092-uftc8inx 3115 4 size size NN cord-010092-uftc8inx 3115 5 was be VBD cord-010092-uftc8inx 3115 6 calculated calculate VBN cord-010092-uftc8inx 3115 7 based base VBN cord-010092-uftc8inx 3115 8 on on IN cord-010092-uftc8inx 3115 9 a a DT cord-010092-uftc8inx 3115 10 one one CD cord-010092-uftc8inx 3115 11 - - HYPH cord-010092-uftc8inx 3115 12 sided sided JJ cord-010092-uftc8inx 3115 13 comparison comparison NN cord-010092-uftc8inx 3115 14 of of IN cord-010092-uftc8inx 3115 15 proportions proportion NNS cord-010092-uftc8inx 3115 16 with with IN cord-010092-uftc8inx 3115 17 the the DT cord-010092-uftc8inx 3115 18 aim aim NN cord-010092-uftc8inx 3115 19 to to TO cord-010092-uftc8inx 3115 20 detect detect VB cord-010092-uftc8inx 3115 21 potential potential JJ cord-010092-uftc8inx 3115 22 specificity specificity NN cord-010092-uftc8inx 3115 23 differences difference NNS cord-010092-uftc8inx 3115 24 ( ( -LRB- cord-010092-uftc8inx 3115 25 a a DT cord-010092-uftc8inx 3115 26 = = SYM cord-010092-uftc8inx 3115 27 10 10 CD cord-010092-uftc8inx 3115 28 % % NN cord-010092-uftc8inx 3115 29 ) ) -RRB- cord-010092-uftc8inx 3115 30 in in IN cord-010092-uftc8inx 3115 31 the the DT cord-010092-uftc8inx 3115 32 size size NN cord-010092-uftc8inx 3115 33 of of IN cord-010092-uftc8inx 3115 34 those those DT cord-010092-uftc8inx 3115 35 specified specify VBN cord-010092-uftc8inx 3115 36 by by IN cord-010092-uftc8inx 3115 37 the the DT cord-010092-uftc8inx 3115 38 manufacturers manufacturer NNS cord-010092-uftc8inx 3115 39 ' ' POS cord-010092-uftc8inx 3115 40 instructions instruction NNS cord-010092-uftc8inx 3115 41 . . . cord-010092-uftc8inx 3116 1 Two two CD cord-010092-uftc8inx 3116 2 different different JJ cord-010092-uftc8inx 3116 3 lots lot NNS cord-010092-uftc8inx 3116 4 were be VBD cord-010092-uftc8inx 3116 5 tested test VBN cord-010092-uftc8inx 3116 6 for for IN cord-010092-uftc8inx 3116 7 the the DT cord-010092-uftc8inx 3116 8 three three CD cord-010092-uftc8inx 3116 9 main main JJ cord-010092-uftc8inx 3116 10 assays assay NNS cord-010092-uftc8inx 3116 11 . . . cord-010092-uftc8inx 3117 1 Results result NNS cord-010092-uftc8inx 3117 2 : : : cord-010092-uftc8inx 3118 1 Out out IN cord-010092-uftc8inx 3118 2 of of IN cord-010092-uftc8inx 3118 3 7,389 7,389 CD cord-010092-uftc8inx 3118 4 plasma plasma NN cord-010092-uftc8inx 3118 5 and and CC cord-010092-uftc8inx 3118 6 2,242 2,242 CD cord-010092-uftc8inx 3118 7 serum serum NN cord-010092-uftc8inx 3118 8 samples sample NNS cord-010092-uftc8inx 3118 9 , , , cord-010092-uftc8inx 3118 10 41 41 CD cord-010092-uftc8inx 3118 11 test test NN cord-010092-uftc8inx 3118 12 results result NNS cord-010092-uftc8inx 3118 13 representing represent VBG cord-010092-uftc8inx 3118 14 37 37 CD cord-010092-uftc8inx 3118 15 individual individual JJ cord-010092-uftc8inx 3118 16 donations donation NNS cord-010092-uftc8inx 3118 17 were be VBD cord-010092-uftc8inx 3118 18 found find VBN cord-010092-uftc8inx 3118 19 RR rr NN cord-010092-uftc8inx 3118 20 on on IN cord-010092-uftc8inx 3118 21 one one CD cord-010092-uftc8inx 3118 22 or or CC cord-010092-uftc8inx 3118 23 both both DT cord-010092-uftc8inx 3118 24 instruments instrument NNS cord-010092-uftc8inx 3118 25 . . . cord-010092-uftc8inx 3119 1 Two two CD cord-010092-uftc8inx 3119 2 samples sample NNS cord-010092-uftc8inx 3119 3 were be VBD cord-010092-uftc8inx 3119 4 confirmed confirm VBN cord-010092-uftc8inx 3119 5 positive positive JJ cord-010092-uftc8inx 3119 6 ( ( -LRB- cord-010092-uftc8inx 3119 7 1 1 CD cord-010092-uftc8inx 3119 8 9 9 CD cord-010092-uftc8inx 3119 9 HBsAg hbsag ADD cord-010092-uftc8inx 3119 10 , , , cord-010092-uftc8inx 3119 11 1 1 CD cord-010092-uftc8inx 3119 12 9 9 CD cord-010092-uftc8inx 3119 13 HCV HCV NNP cord-010092-uftc8inx 3119 14 ) ) -RRB- cord-010092-uftc8inx 3119 15 , , , cord-010092-uftc8inx 3119 16 two two CD cord-010092-uftc8inx 3119 17 others other NNS cord-010092-uftc8inx 3119 18 were be VBD cord-010092-uftc8inx 3119 19 indeterminate indeterminate JJ cord-010092-uftc8inx 3119 20 . . . cord-010092-uftc8inx 3120 1 The the DT cord-010092-uftc8inx 3120 2 sample sample NN cord-010092-uftc8inx 3120 3 containing contain VBG cord-010092-uftc8inx 3120 4 low low JJ cord-010092-uftc8inx 3120 5 level level NN cord-010092-uftc8inx 3120 6 antibodies antibody NNS cord-010092-uftc8inx 3120 7 against against IN cord-010092-uftc8inx 3120 8 HCV HCV NNP cord-010092-uftc8inx 3120 9 was be VBD cord-010092-uftc8inx 3120 10 PCR PCR NNP cord-010092-uftc8inx 3120 11 negative negative JJ cord-010092-uftc8inx 3120 12 and and CC cord-010092-uftc8inx 3120 13 only only RB cord-010092-uftc8inx 3120 14 detected detect VBN cord-010092-uftc8inx 3120 15 by by IN cord-010092-uftc8inx 3120 16 the the DT cord-010092-uftc8inx 3120 17 Roche Roche NNP cord-010092-uftc8inx 3120 18 system system NN cord-010092-uftc8inx 3120 19 . . . cord-010092-uftc8inx 3121 1 The the DT cord-010092-uftc8inx 3121 2 percentage percentage NN cord-010092-uftc8inx 3121 3 of of IN cord-010092-uftc8inx 3121 4 false false JJ cord-010092-uftc8inx 3121 5 reactive reactive JJ cord-010092-uftc8inx 3121 6 results result NNS cord-010092-uftc8inx 3121 7 for for IN cord-010092-uftc8inx 3121 8 the the DT cord-010092-uftc8inx 3121 9 five five CD cord-010092-uftc8inx 3121 10 assays assay NNS cord-010092-uftc8inx 3121 11 on on IN cord-010092-uftc8inx 3121 12 the the DT cord-010092-uftc8inx 3121 13 two two CD cord-010092-uftc8inx 3121 14 systems system NNS cord-010092-uftc8inx 3121 15 were be VBD cord-010092-uftc8inx 3121 16 ( ( -LRB- cord-010092-uftc8inx 3121 17 Alinity Alinity NNP cord-010092-uftc8inx 3121 18 s s POS cord-010092-uftc8inx 3121 19 / / SYM cord-010092-uftc8inx 3121 20 e801 e801 NNS cord-010092-uftc8inx 3121 21 ) ) -RRB- cord-010092-uftc8inx 3121 22 : : : cord-010092-uftc8inx 3122 1 HBs HBs NNP cord-010092-uftc8inx 3122 2 Ag Ag NNP cord-010092-uftc8inx 3122 3 : : : cord-010092-uftc8inx 3123 1 0.04/0.03 0.04/0.03 CD cord-010092-uftc8inx 3123 2 % % NN cord-010092-uftc8inx 3123 3 in in IN cord-010092-uftc8inx 3123 4 a a DT cord-010092-uftc8inx 3123 5 total total NN cord-010092-uftc8inx 3123 6 of of IN cord-010092-uftc8inx 3123 7 9590/9589 9590/9589 CD cord-010092-uftc8inx 3123 8 samples sample NNS cord-010092-uftc8inx 3123 9 tested test VBN cord-010092-uftc8inx 3123 10 ; ; : cord-010092-uftc8inx 3123 11 HCV HCV NNP cord-010092-uftc8inx 3123 12 Ab Ab NNP cord-010092-uftc8inx 3123 13 : : : cord-010092-uftc8inx 3123 14 0.01/0.09 0.01/0.09 CD cord-010092-uftc8inx 3123 15 % % NN cord-010092-uftc8inx 3123 16 in in IN cord-010092-uftc8inx 3123 17 9620/9585 9620/9585 CD cord-010092-uftc8inx 3123 18 , , , cord-010092-uftc8inx 3123 19 P p NN cord-010092-uftc8inx 3123 20 < < XX cord-010092-uftc8inx 3123 21 10 10 CD cord-010092-uftc8inx 3123 22 % % NN cord-010092-uftc8inx 3123 23 ; ; . cord-010092-uftc8inx 3124 1 HIV HIV NNP cord-010092-uftc8inx 3124 2 Ag Ag NNP cord-010092-uftc8inx 3124 3 / / SYM cord-010092-uftc8inx 3124 4 Ab ab NN cord-010092-uftc8inx 3124 5 : : : cord-010092-uftc8inx 3124 6 0.03/0.09 0.03/0.09 CD cord-010092-uftc8inx 3124 7 % % NN cord-010092-uftc8inx 3124 8 in in IN cord-010092-uftc8inx 3124 9 9362/9329 9362/9329 CD cord-010092-uftc8inx 3124 10 , , , cord-010092-uftc8inx 3124 11 P p NN cord-010092-uftc8inx 3124 12 < < XX cord-010092-uftc8inx 3124 13 10 10 CD cord-010092-uftc8inx 3124 14 % % NN cord-010092-uftc8inx 3124 15 ; ; , cord-010092-uftc8inx 3124 16 Syphilis Syphilis NNP cord-010092-uftc8inx 3124 17 Ab ab NN cord-010092-uftc8inx 3124 18 : : : cord-010092-uftc8inx 3124 19 0.1/0.07 0.1/0.07 CD cord-010092-uftc8inx 3124 20 % % NN cord-010092-uftc8inx 3124 21 in in IN cord-010092-uftc8inx 3124 22 2971/2987 2971/2987 CD cord-010092-uftc8inx 3124 23 ; ; : cord-010092-uftc8inx 3124 24 HBc HBc NNP cord-010092-uftc8inx 3124 25 : : : cord-010092-uftc8inx 3124 26 0/0 0/0 CD cord-010092-uftc8inx 3124 27 % % NN cord-010092-uftc8inx 3124 28 in in IN cord-010092-uftc8inx 3124 29 1531/1549 1531/1549 CD cord-010092-uftc8inx 3124 30 . . . cord-010092-uftc8inx 3125 1 No no DT cord-010092-uftc8inx 3125 2 significant significant JJ cord-010092-uftc8inx 3125 3 difference difference NN cord-010092-uftc8inx 3125 4 was be VBD cord-010092-uftc8inx 3125 5 found find VBN cord-010092-uftc8inx 3125 6 between between IN cord-010092-uftc8inx 3125 7 the the DT cord-010092-uftc8inx 3125 8 calculated calculate VBN cord-010092-uftc8inx 3125 9 specificities specificity NNS cord-010092-uftc8inx 3125 10 in in IN cord-010092-uftc8inx 3125 11 our -PRON- PRP$ cord-010092-uftc8inx 3125 12 study study NN cord-010092-uftc8inx 3125 13 and and CC cord-010092-uftc8inx 3125 14 the the DT cord-010092-uftc8inx 3125 15 manufacturers manufacturer NNS cord-010092-uftc8inx 3125 16 ' ' POS cord-010092-uftc8inx 3125 17 data datum NNS cord-010092-uftc8inx 3125 18 . . . cord-010092-uftc8inx 3126 1 A a DT cord-010092-uftc8inx 3126 2 potential potential JJ cord-010092-uftc8inx 3126 3 influence influence NN cord-010092-uftc8inx 3126 4 of of IN cord-010092-uftc8inx 3126 5 sample sample NN cord-010092-uftc8inx 3126 6 matrix matrix NN cord-010092-uftc8inx 3126 7 and and CC cord-010092-uftc8inx 3126 8 kit kit NN cord-010092-uftc8inx 3126 9 lots lot NNS cord-010092-uftc8inx 3126 10 was be VBD cord-010092-uftc8inx 3126 11 assessed assess VBN cord-010092-uftc8inx 3126 12 . . . cord-010092-uftc8inx 3127 1 A a DT cord-010092-uftc8inx 3127 2 trend trend NN cord-010092-uftc8inx 3127 3 towards towards IN cord-010092-uftc8inx 3127 4 more more RBR cord-010092-uftc8inx 3127 5 false false JJ cord-010092-uftc8inx 3127 6 reactive reactive JJ cord-010092-uftc8inx 3127 7 results result NNS cord-010092-uftc8inx 3127 8 in in IN cord-010092-uftc8inx 3127 9 serum serum NN cord-010092-uftc8inx 3127 10 vs vs IN cord-010092-uftc8inx 3127 11 plasma plasma NN cord-010092-uftc8inx 3127 12 was be VBD cord-010092-uftc8inx 3127 13 found find VBN cord-010092-uftc8inx 3127 14 for for IN cord-010092-uftc8inx 3127 15 nearly nearly RB cord-010092-uftc8inx 3127 16 all all DT cord-010092-uftc8inx 3127 17 assays assay NNS cord-010092-uftc8inx 3127 18 . . . cord-010092-uftc8inx 3128 1 No no DT cord-010092-uftc8inx 3128 2 clear clear RB cord-010092-uftc8inx 3128 3 - - HYPH cord-010092-uftc8inx 3128 4 cut cut VBN cord-010092-uftc8inx 3128 5 statistical statistical JJ cord-010092-uftc8inx 3128 6 difference difference NN cord-010092-uftc8inx 3128 7 was be VBD cord-010092-uftc8inx 3128 8 seen see VBN cord-010092-uftc8inx 3128 9 between between IN cord-010092-uftc8inx 3128 10 lots lot NNS cord-010092-uftc8inx 3128 11 . . . cord-010092-uftc8inx 3129 1 Summary Summary NNP cord-010092-uftc8inx 3129 2 / / SYM cord-010092-uftc8inx 3129 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 3129 4 : : : cord-010092-uftc8inx 3130 1 The the DT cord-010092-uftc8inx 3130 2 study study NN cord-010092-uftc8inx 3130 3 results result NNS cord-010092-uftc8inx 3130 4 are be VBP cord-010092-uftc8inx 3130 5 in in IN cord-010092-uftc8inx 3130 6 line line NN cord-010092-uftc8inx 3130 7 with with IN cord-010092-uftc8inx 3130 8 the the DT cord-010092-uftc8inx 3130 9 manufacturers manufacturer NNS cord-010092-uftc8inx 3130 10 ' ' POS cord-010092-uftc8inx 3130 11 specificity specificity NN cord-010092-uftc8inx 3130 12 data datum NNS cord-010092-uftc8inx 3130 13 , , , cord-010092-uftc8inx 3130 14 showing show VBG cord-010092-uftc8inx 3130 15 that that IN cord-010092-uftc8inx 3130 16 the the DT cord-010092-uftc8inx 3130 17 Alinity Alinity NNP cord-010092-uftc8inx 3130 18 s s POS cord-010092-uftc8inx 3130 19 HCV HCV NNP cord-010092-uftc8inx 3130 20 Ab Ab NNP cord-010092-uftc8inx 3130 21 and and CC cord-010092-uftc8inx 3130 22 HIV HIV NNP cord-010092-uftc8inx 3130 23 Ag Ag NNP cord-010092-uftc8inx 3130 24 / / SYM cord-010092-uftc8inx 3130 25 Ab Ab NNP cord-010092-uftc8inx 3130 26 assay assay NN cord-010092-uftc8inx 3130 27 show show VBP cord-010092-uftc8inx 3130 28 a a DT cord-010092-uftc8inx 3130 29 slightly slightly RB cord-010092-uftc8inx 3130 30 higher high JJR cord-010092-uftc8inx 3130 31 specificity specificity NN cord-010092-uftc8inx 3130 32 in in IN cord-010092-uftc8inx 3130 33 a a DT cord-010092-uftc8inx 3130 34 population population NN cord-010092-uftc8inx 3130 35 of of IN cord-010092-uftc8inx 3130 36 plasma plasma NN cord-010092-uftc8inx 3130 37 and and CC cord-010092-uftc8inx 3130 38 serum serum NN cord-010092-uftc8inx 3130 39 samples sample NNS cord-010092-uftc8inx 3130 40 from from IN cord-010092-uftc8inx 3130 41 repeat repeat NN cord-010092-uftc8inx 3130 42 donors donor NNS cord-010092-uftc8inx 3130 43 prescreened prescreene VBN cord-010092-uftc8inx 3130 44 by by IN cord-010092-uftc8inx 3130 45 PRISM PRISM NNP cord-010092-uftc8inx 3130 46 . . . cord-010092-uftc8inx 3131 1 A a DT cord-010092-uftc8inx 3131 2 possible possible JJ cord-010092-uftc8inx 3131 3 influence influence NN cord-010092-uftc8inx 3131 4 on on IN cord-010092-uftc8inx 3131 5 the the DT cord-010092-uftc8inx 3131 6 test test NN cord-010092-uftc8inx 3131 7 specificity specificity NN cord-010092-uftc8inx 3131 8 by by IN cord-010092-uftc8inx 3131 9 the the DT cord-010092-uftc8inx 3131 10 sample sample NN cord-010092-uftc8inx 3131 11 matrix matrix NN cord-010092-uftc8inx 3131 12 was be VBD cord-010092-uftc8inx 3131 13 detected detect VBN cord-010092-uftc8inx 3131 14 but but CC cord-010092-uftc8inx 3131 15 needs need VBZ cord-010092-uftc8inx 3131 16 further further JJ cord-010092-uftc8inx 3131 17 investigation investigation NN cord-010092-uftc8inx 3131 18 . . . cord-010092-uftc8inx 3132 1 The the DT cord-010092-uftc8inx 3132 2 possibility possibility NN cord-010092-uftc8inx 3132 3 to to TO cord-010092-uftc8inx 3132 4 edit edit VB cord-010092-uftc8inx 3132 5 complex complex JJ cord-010092-uftc8inx 3132 6 genomes genome NNS cord-010092-uftc8inx 3132 7 in in IN cord-010092-uftc8inx 3132 8 a a DT cord-010092-uftc8inx 3132 9 targeted target VBN cord-010092-uftc8inx 3132 10 fashion fashion NN cord-010092-uftc8inx 3132 11 has have VBZ cord-010092-uftc8inx 3132 12 not not RB cord-010092-uftc8inx 3132 13 only only RB cord-010092-uftc8inx 3132 14 revolutionized revolutionize VBN cord-010092-uftc8inx 3132 15 basic basic JJ cord-010092-uftc8inx 3132 16 research research NN cord-010092-uftc8inx 3132 17 but but CC cord-010092-uftc8inx 3132 18 biotechnological biotechnological JJ cord-010092-uftc8inx 3132 19 and and CC cord-010092-uftc8inx 3132 20 therapeutic therapeutic JJ cord-010092-uftc8inx 3132 21 applications application NNS cord-010092-uftc8inx 3132 22 as as RB cord-010092-uftc8inx 3132 23 well well RB cord-010092-uftc8inx 3132 24 . . . cord-010092-uftc8inx 3133 1 With with IN cord-010092-uftc8inx 3133 2 the the DT cord-010092-uftc8inx 3133 3 rapid rapid JJ cord-010092-uftc8inx 3133 4 development development NN cord-010092-uftc8inx 3133 5 of of IN cord-010092-uftc8inx 3133 6 genome genome NN cord-010092-uftc8inx 3133 7 editing editing NN cord-010092-uftc8inx 3133 8 tools tool NNS cord-010092-uftc8inx 3133 9 , , , cord-010092-uftc8inx 3133 10 in in IN cord-010092-uftc8inx 3133 11 particular particular JJ cord-010092-uftc8inx 3133 12 zinc zinc NN cord-010092-uftc8inx 3133 13 - - HYPH cord-010092-uftc8inx 3133 14 finger finger NN cord-010092-uftc8inx 3133 15 nucleases nuclease NNS cord-010092-uftc8inx 3133 16 ( ( -LRB- cord-010092-uftc8inx 3133 17 ZFNs ZFNs NNP cord-010092-uftc8inx 3133 18 ) ) -RRB- cord-010092-uftc8inx 3133 19 , , , cord-010092-uftc8inx 3133 20 transcription transcription NN cord-010092-uftc8inx 3133 21 activator activator NN cord-010092-uftc8inx 3133 22 - - HYPH cord-010092-uftc8inx 3133 23 like like JJ cord-010092-uftc8inx 3133 24 effector effector NN cord-010092-uftc8inx 3133 25 nucleases nuclease NNS cord-010092-uftc8inx 3133 26 ( ( -LRB- cord-010092-uftc8inx 3133 27 TALENs TALENs NNP cord-010092-uftc8inx 3133 28 ) ) -RRB- cord-010092-uftc8inx 3133 29 , , , cord-010092-uftc8inx 3133 30 and and CC cord-010092-uftc8inx 3133 31 the the DT cord-010092-uftc8inx 3133 32 CRISPR CRISPR NNP cord-010092-uftc8inx 3133 33 - - HYPH cord-010092-uftc8inx 3133 34 Cas Cas NNP cord-010092-uftc8inx 3133 35 system system NN cord-010092-uftc8inx 3133 36 , , , cord-010092-uftc8inx 3133 37 a a DT cord-010092-uftc8inx 3133 38 wide wide JJ cord-010092-uftc8inx 3133 39 range range NN cord-010092-uftc8inx 3133 40 of of IN cord-010092-uftc8inx 3133 41 therapeutic therapeutic JJ cord-010092-uftc8inx 3133 42 options option NNS cord-010092-uftc8inx 3133 43 have have VBP cord-010092-uftc8inx 3134 1 beenand beenand NNP cord-010092-uftc8inx 3134 2 will will MD cord-010092-uftc8inx 3134 3 bedeveloped bedeveloped VB cord-010092-uftc8inx 3134 4 at at IN cord-010092-uftc8inx 3134 5 an an DT cord-010092-uftc8inx 3134 6 unprecedented unprecedented JJ cord-010092-uftc8inx 3134 7 speed speed NN cord-010092-uftc8inx 3134 8 . . . cord-010092-uftc8inx 3135 1 Therapeutic therapeutic JJ cord-010092-uftc8inx 3135 2 genome genome NN cord-010092-uftc8inx 3135 3 editing editing NN cord-010092-uftc8inx 3135 4 in in IN cord-010092-uftc8inx 3135 5 hematopoietic hematopoietic JJ cord-010092-uftc8inx 3135 6 cells cell NNS cord-010092-uftc8inx 3135 7 enable enable VBP cord-010092-uftc8inx 3135 8 new new JJ cord-010092-uftc8inx 3135 9 interventions intervention NNS cord-010092-uftc8inx 3135 10 in in IN cord-010092-uftc8inx 3135 11 the the DT cord-010092-uftc8inx 3135 12 blood blood NN cord-010092-uftc8inx 3135 13 and and CC cord-010092-uftc8inx 3135 14 immune immune JJ cord-010092-uftc8inx 3135 15 system system NN cord-010092-uftc8inx 3135 16 , , , cord-010092-uftc8inx 3135 17 including include VBG cord-010092-uftc8inx 3135 18 novel novel NN cord-010092-uftc8inx 3135 19 approaches approach NNS cord-010092-uftc8inx 3135 20 to to TO cord-010092-uftc8inx 3135 21 treat treat VB cord-010092-uftc8inx 3135 22 immunological immunological JJ cord-010092-uftc8inx 3135 23 disorders disorder NNS cord-010092-uftc8inx 3135 24 , , , cord-010092-uftc8inx 3135 25 infectious infectious JJ cord-010092-uftc8inx 3135 26 diseases disease NNS cord-010092-uftc8inx 3135 27 , , , cord-010092-uftc8inx 3135 28 and and CC cord-010092-uftc8inx 3135 29 cancer cancer NN cord-010092-uftc8inx 3135 30 . . . cord-010092-uftc8inx 3136 1 We -PRON- PRP cord-010092-uftc8inx 3136 2 have have VBP cord-010092-uftc8inx 3136 3 developed develop VBN cord-010092-uftc8inx 3136 4 GMP GMP NNP cord-010092-uftc8inx 3136 5 - - HYPH cord-010092-uftc8inx 3136 6 compliant compliant JJ cord-010092-uftc8inx 3136 7 protocols protocol NNS cord-010092-uftc8inx 3136 8 to to TO cord-010092-uftc8inx 3136 9 manufacture manufacture VB cord-010092-uftc8inx 3136 10 gene gene NN cord-010092-uftc8inx 3136 11 edited edit VBN cord-010092-uftc8inx 3136 12 CD34 CD34 NNP cord-010092-uftc8inx 3136 13 + + CC cord-010092-uftc8inx 3136 14 hematopoietic hematopoietic JJ cord-010092-uftc8inx 3136 15 stem stem NN cord-010092-uftc8inx 3136 16 and and CC cord-010092-uftc8inx 3136 17 precursor precursor NN cord-010092-uftc8inx 3136 18 cells cell NNS cord-010092-uftc8inx 3136 19 ( ( -LRB- cord-010092-uftc8inx 3136 20 HSPCs hspc NNS cord-010092-uftc8inx 3136 21 ) ) -RRB- cord-010092-uftc8inx 3136 22 as as RB cord-010092-uftc8inx 3136 23 well well RB cord-010092-uftc8inx 3136 24 as as IN cord-010092-uftc8inx 3136 25 chimeric chimeric JJ cord-010092-uftc8inx 3136 26 antigen antigen NN cord-010092-uftc8inx 3136 27 receptor receptor NN cord-010092-uftc8inx 3136 28 ( ( -LRB- cord-010092-uftc8inx 3136 29 CAR car NN cord-010092-uftc8inx 3136 30 ) ) -RRB- cord-010092-uftc8inx 3136 31 T t NN cord-010092-uftc8inx 3136 32 cells cell NNS cord-010092-uftc8inx 3136 33 , , , cord-010092-uftc8inx 3136 34 with with IN cord-010092-uftc8inx 3136 35 the the DT cord-010092-uftc8inx 3136 36 final final JJ cord-010092-uftc8inx 3136 37 goal goal NN cord-010092-uftc8inx 3136 38 to to TO cord-010092-uftc8inx 3136 39 provide provide VB cord-010092-uftc8inx 3136 40 novel novel JJ cord-010092-uftc8inx 3136 41 cell cell NN cord-010092-uftc8inx 3136 42 therapies therapy NNS cord-010092-uftc8inx 3136 43 for for IN cord-010092-uftc8inx 3136 44 patients patient NNS cord-010092-uftc8inx 3136 45 suffering suffer VBG cord-010092-uftc8inx 3136 46 from from IN cord-010092-uftc8inx 3136 47 primary primary JJ cord-010092-uftc8inx 3136 48 immunodeficiencies immunodeficiency NNS cord-010092-uftc8inx 3136 49 , , , cord-010092-uftc8inx 3136 50 chronic chronic JJ cord-010092-uftc8inx 3136 51 infection infection NN cord-010092-uftc8inx 3136 52 with with IN cord-010092-uftc8inx 3136 53 human human JJ cord-010092-uftc8inx 3136 54 immunodeficiency immunodeficiency NN cord-010092-uftc8inx 3136 55 virus virus NN cord-010092-uftc8inx 3136 56 type type NN cord-010092-uftc8inx 3136 57 1 1 CD cord-010092-uftc8inx 3136 58 ( ( -LRB- cord-010092-uftc8inx 3136 59 HIV-1 HIV-1 NNP cord-010092-uftc8inx 3136 60 ) ) -RRB- cord-010092-uftc8inx 3136 61 , , , cord-010092-uftc8inx 3136 62 and and CC cord-010092-uftc8inx 3136 63 some some DT cord-010092-uftc8inx 3136 64 tumor tumor NN cord-010092-uftc8inx 3136 65 entities entity NNS cord-010092-uftc8inx 3136 66 . . . cord-010092-uftc8inx 3137 1 Despite despite IN cord-010092-uftc8inx 3137 2 great great JJ cord-010092-uftc8inx 3137 3 success success NN cord-010092-uftc8inx 3137 4 in in IN cord-010092-uftc8inx 3137 5 improving improve VBG cord-010092-uftc8inx 3137 6 their -PRON- PRP$ cord-010092-uftc8inx 3137 7 specificity specificity NN cord-010092-uftc8inx 3137 8 , , , cord-010092-uftc8inx 3137 9 engineered engineer VBN cord-010092-uftc8inx 3137 10 designer designer NN cord-010092-uftc8inx 3137 11 nucleases nuclease NNS cord-010092-uftc8inx 3137 12 can can MD cord-010092-uftc8inx 3137 13 induce induce VB cord-010092-uftc8inx 3137 14 genotoxic genotoxic JJ cord-010092-uftc8inx 3137 15 side side NN cord-010092-uftc8inx 3137 16 effects effect NNS cord-010092-uftc8inx 3137 17 by by IN cord-010092-uftc8inx 3137 18 introducing introduce VBG cord-010092-uftc8inx 3137 19 mutations mutation NNS cord-010092-uftc8inx 3137 20 or or CC cord-010092-uftc8inx 3137 21 chromosomal chromosomal JJ cord-010092-uftc8inx 3137 22 aberrations aberration NNS cord-010092-uftc8inx 3137 23 . . . cord-010092-uftc8inx 3138 1 We -PRON- PRP cord-010092-uftc8inx 3138 2 have have VBP cord-010092-uftc8inx 3138 3 established establish VBN cord-010092-uftc8inx 3138 4 novel novel JJ cord-010092-uftc8inx 3138 5 genome genome NN cord-010092-uftc8inx 3138 6 - - HYPH cord-010092-uftc8inx 3138 7 wide wide JJ cord-010092-uftc8inx 3138 8 assays assay NNS cord-010092-uftc8inx 3138 9 that that WDT cord-010092-uftc8inx 3138 10 enable enable VBP cord-010092-uftc8inx 3138 11 us -PRON- PRP cord-010092-uftc8inx 3138 12 to to TO cord-010092-uftc8inx 3138 13 detect detect VB cord-010092-uftc8inx 3138 14 chromosomal chromosomal JJ cord-010092-uftc8inx 3138 15 aberrations aberration NNS cord-010092-uftc8inx 3138 16 induced induce VBN cord-010092-uftc8inx 3138 17 not not RB cord-010092-uftc8inx 3138 18 only only RB cord-010092-uftc8inx 3138 19 by by IN cord-010092-uftc8inx 3138 20 off off IN cord-010092-uftc8inx 3138 21 - - HYPH cord-010092-uftc8inx 3138 22 target target NN cord-010092-uftc8inx 3138 23 activity activity NN cord-010092-uftc8inx 3138 24 but but CC cord-010092-uftc8inx 3138 25 also also RB cord-010092-uftc8inx 3138 26 by by IN cord-010092-uftc8inx 3138 27 on on IN cord-010092-uftc8inx 3138 28 - - HYPH cord-010092-uftc8inx 3138 29 target target NN cord-010092-uftc8inx 3138 30 activity activity NN cord-010092-uftc8inx 3138 31 , , , cord-010092-uftc8inx 3138 32 such such JJ cord-010092-uftc8inx 3138 33 as as IN cord-010092-uftc8inx 3138 34 micro micro NNS cord-010092-uftc8inx 3138 35 - - NNS cord-010092-uftc8inx 3138 36 aberrations aberration NNS cord-010092-uftc8inx 3138 37 and and CC cord-010092-uftc8inx 3138 38 translocations translocation NNS cord-010092-uftc8inx 3138 39 , , , cord-010092-uftc8inx 3138 40 with with IN cord-010092-uftc8inx 3138 41 unparalleled unparalleled JJ cord-010092-uftc8inx 3138 42 sensitivity sensitivity NN cord-010092-uftc8inx 3138 43 . . . cord-010092-uftc8inx 3139 1 In in IN cord-010092-uftc8inx 3139 2 toto toto NNP cord-010092-uftc8inx 3139 3 , , , cord-010092-uftc8inx 3139 4 our -PRON- PRP$ cord-010092-uftc8inx 3139 5 developed develop VBN cord-010092-uftc8inx 3139 6 protocols protocol NNS cord-010092-uftc8inx 3139 7 allow allow VBP cord-010092-uftc8inx 3139 8 us -PRON- PRP cord-010092-uftc8inx 3139 9 to to TO cord-010092-uftc8inx 3139 10 achieve achieve VB cord-010092-uftc8inx 3139 11 genome genome NN cord-010092-uftc8inx 3139 12 editing editing NN cord-010092-uftc8inx 3139 13 in in IN cord-010092-uftc8inx 3139 14 hematopoietic hematopoietic JJ cord-010092-uftc8inx 3139 15 cells cell NNS cord-010092-uftc8inx 3139 16 with with IN cord-010092-uftc8inx 3139 17 high high JJ cord-010092-uftc8inx 3139 18 efficiency efficiency NN cord-010092-uftc8inx 3139 19 and and CC cord-010092-uftc8inx 3139 20 to to TO cord-010092-uftc8inx 3139 21 assess assess VB cord-010092-uftc8inx 3139 22 the the DT cord-010092-uftc8inx 3139 23 genotoxic genotoxic JJ cord-010092-uftc8inx 3139 24 risk risk NN cord-010092-uftc8inx 3139 25 associated associate VBN cord-010092-uftc8inx 3139 26 with with IN cord-010092-uftc8inx 3139 27 the the DT cord-010092-uftc8inx 3139 28 expression expression NN cord-010092-uftc8inx 3139 29 of of IN cord-010092-uftc8inx 3139 30 CRISPR CRISPR NNP cord-010092-uftc8inx 3139 31 - - HYPH cord-010092-uftc8inx 3139 32 Cas Cas NNP cord-010092-uftc8inx 3139 33 nucleases nuclease NNS cord-010092-uftc8inx 3139 34 and and CC cord-010092-uftc8inx 3139 35 TALENs talen NNS cord-010092-uftc8inx 3139 36 in in IN cord-010092-uftc8inx 3139 37 clinically clinically RB cord-010092-uftc8inx 3139 38 relevant relevant JJ cord-010092-uftc8inx 3139 39 human human JJ cord-010092-uftc8inx 3139 40 cells cell NNS cord-010092-uftc8inx 3139 41 , , , cord-010092-uftc8inx 3139 42 so so IN cord-010092-uftc8inx 3139 43 forming form VBG cord-010092-uftc8inx 3139 44 the the DT cord-010092-uftc8inx 3139 45 basis basis NN cord-010092-uftc8inx 3139 46 for for IN cord-010092-uftc8inx 3139 47 planned planned JJ cord-010092-uftc8inx 3139 48 phase phase NN cord-010092-uftc8inx 3139 49 I I NNP cord-010092-uftc8inx 3139 50 / / SYM cord-010092-uftc8inx 3139 51 II II NNP cord-010092-uftc8inx 3139 52 clinical clinical JJ cord-010092-uftc8inx 3139 53 studies study NNS cord-010092-uftc8inx 3139 54 . . . cord-010092-uftc8inx 3140 1 Adoptive adoptive JJ cord-010092-uftc8inx 3140 2 T T NNP cord-010092-uftc8inx 3140 3 cell cell NN cord-010092-uftc8inx 3140 4 therapy therapy NN cord-010092-uftc8inx 3140 5 ( ( -LRB- cord-010092-uftc8inx 3140 6 ACT ACT NNP cord-010092-uftc8inx 3140 7 ) ) -RRB- cord-010092-uftc8inx 3140 8 has have VBZ cord-010092-uftc8inx 3140 9 proven prove VBN cord-010092-uftc8inx 3140 10 a a DT cord-010092-uftc8inx 3140 11 potent potent JJ cord-010092-uftc8inx 3140 12 means mean NNS cord-010092-uftc8inx 3140 13 to to TO cord-010092-uftc8inx 3140 14 treat treat VB cord-010092-uftc8inx 3140 15 blood blood NN cord-010092-uftc8inx 3140 16 - - HYPH cord-010092-uftc8inx 3140 17 borne bear VBN cord-010092-uftc8inx 3140 18 tumors tumor NNS cord-010092-uftc8inx 3140 19 and and CC cord-010092-uftc8inx 3140 20 solid solid JJ cord-010092-uftc8inx 3140 21 tumors tumor NNS cord-010092-uftc8inx 3140 22 . . . cord-010092-uftc8inx 3141 1 Adoptive adoptive JJ cord-010092-uftc8inx 3141 2 cell cell NN cord-010092-uftc8inx 3141 3 therapies therapy NNS cord-010092-uftc8inx 3141 4 include include VBP cord-010092-uftc8inx 3141 5 T t NN cord-010092-uftc8inx 3141 6 cells cell NNS cord-010092-uftc8inx 3141 7 that that WDT cord-010092-uftc8inx 3141 8 are be VBP cord-010092-uftc8inx 3141 9 genetically genetically RB cord-010092-uftc8inx 3141 10 engineered engineer VBN cord-010092-uftc8inx 3141 11 with with IN cord-010092-uftc8inx 3141 12 tumor tumor NN cord-010092-uftc8inx 3141 13 specific specific JJ cord-010092-uftc8inx 3141 14 T t NN cord-010092-uftc8inx 3141 15 cell cell NN cord-010092-uftc8inx 3141 16 receptors receptor NNS cord-010092-uftc8inx 3141 17 ( ( -LRB- cord-010092-uftc8inx 3141 18 TCRs TCRs NNP cord-010092-uftc8inx 3141 19 ) ) -RRB- cord-010092-uftc8inx 3141 20 , , , cord-010092-uftc8inx 3141 21 or or CC cord-010092-uftc8inx 3141 22 with with IN cord-010092-uftc8inx 3141 23 chimeric chimeric JJ cord-010092-uftc8inx 3141 24 antigen antigen NN cord-010092-uftc8inx 3141 25 receptors receptor NNS cord-010092-uftc8inx 3141 26 ( ( -LRB- cord-010092-uftc8inx 3141 27 CARs car NNS cord-010092-uftc8inx 3141 28 ) ) -RRB- cord-010092-uftc8inx 3141 29 . . . cord-010092-uftc8inx 3142 1 In in IN cord-010092-uftc8inx 3142 2 addition addition NN cord-010092-uftc8inx 3142 3 , , , cord-010092-uftc8inx 3142 4 tumor tumor NN cord-010092-uftc8inx 3142 5 infiltrating infiltrate VBG cord-010092-uftc8inx 3142 6 cells cell NNS cord-010092-uftc8inx 3142 7 ( ( -LRB- cord-010092-uftc8inx 3142 8 TILs TILs NNP cord-010092-uftc8inx 3142 9 ) ) -RRB- cord-010092-uftc8inx 3142 10 can can MD cord-010092-uftc8inx 3142 11 be be VB cord-010092-uftc8inx 3142 12 isolated isolate VBN cord-010092-uftc8inx 3142 13 from from IN cord-010092-uftc8inx 3142 14 tumor tumor NN cord-010092-uftc8inx 3142 15 lesions lesion NNS cord-010092-uftc8inx 3142 16 , , , cord-010092-uftc8inx 3142 17 which which WDT cord-010092-uftc8inx 3142 18 are be VBP cord-010092-uftc8inx 3142 19 then then RB cord-010092-uftc8inx 3142 20 expanded expand VBN cord-010092-uftc8inx 3142 21 and and CC cord-010092-uftc8inx 3142 22 reprogrammed reprogramme VBN cord-010092-uftc8inx 3142 23 in in IN cord-010092-uftc8inx 3142 24 vitro vitro FW cord-010092-uftc8inx 3142 25 prior prior RB cord-010092-uftc8inx 3142 26 to to IN cord-010092-uftc8inx 3142 27 transfusion transfusion NN cord-010092-uftc8inx 3142 28 into into IN cord-010092-uftc8inx 3142 29 the the DT cord-010092-uftc8inx 3142 30 patient patient NN cord-010092-uftc8inx 3142 31 . . . cord-010092-uftc8inx 3143 1 The the DT cord-010092-uftc8inx 3143 2 anti anti JJ cord-010092-uftc8inx 3143 3 - - JJ cord-010092-uftc8inx 3143 4 tumoral tumoral JJ cord-010092-uftc8inx 3143 5 efficacy efficacy NN cord-010092-uftc8inx 3143 6 of of IN cord-010092-uftc8inx 3143 7 ACT ACT NNP cord-010092-uftc8inx 3143 8 products product NNS cord-010092-uftc8inx 3143 9 depends depend VBZ cord-010092-uftc8inx 3143 10 on on IN cord-010092-uftc8inx 3143 11 several several JJ cord-010092-uftc8inx 3143 12 parameters parameter NNS cord-010092-uftc8inx 3143 13 , , , cord-010092-uftc8inx 3143 14 including include VBG cord-010092-uftc8inx 3143 15 the the DT cord-010092-uftc8inx 3143 16 capacity capacity NN cord-010092-uftc8inx 3143 17 of of IN cord-010092-uftc8inx 3143 18 CD8 CD8 NNP cord-010092-uftc8inx 3143 19 + + CC cord-010092-uftc8inx 3143 20 T T NNP cord-010092-uftc8inx 3143 21 cells cell NNS cord-010092-uftc8inx 3143 22 to to TO cord-010092-uftc8inx 3143 23 produce produce VB cord-010092-uftc8inx 3143 24 cytokines cytokine NNS cord-010092-uftc8inx 3143 25 , , , cord-010092-uftc8inx 3143 26 chemokines chemokine NNS cord-010092-uftc8inx 3143 27 and and CC cord-010092-uftc8inx 3143 28 granzymes granzyme NNS cord-010092-uftc8inx 3143 29 , , , cord-010092-uftc8inx 3143 30 a a DT cord-010092-uftc8inx 3143 31 feature feature NN cord-010092-uftc8inx 3143 32 that that WDT cord-010092-uftc8inx 3143 33 is be VBZ cord-010092-uftc8inx 3143 34 critical critical JJ cord-010092-uftc8inx 3143 35 for for IN cord-010092-uftc8inx 3143 36 effective effective JJ cord-010092-uftc8inx 3143 37 anti anti JJ cord-010092-uftc8inx 3143 38 - - JJ cord-010092-uftc8inx 3143 39 tumoral tumoral JJ cord-010092-uftc8inx 3143 40 responses response NNS cord-010092-uftc8inx 3143 41 . . . cord-010092-uftc8inx 3144 1 Here here RB cord-010092-uftc8inx 3144 2 I -PRON- PRP cord-010092-uftc8inx 3144 3 will will MD cord-010092-uftc8inx 3144 4 discuss discuss VB cord-010092-uftc8inx 3144 5 our -PRON- PRP$ cord-010092-uftc8inx 3144 6 efforts effort NNS cord-010092-uftc8inx 3144 7 to to TO cord-010092-uftc8inx 3144 8 develop develop VB cord-010092-uftc8inx 3144 9 and and CC cord-010092-uftc8inx 3144 10 improve improve VB cord-010092-uftc8inx 3144 11 ACT act NN cord-010092-uftc8inx 3144 12 products product NNS cord-010092-uftc8inx 3144 13 for for IN cord-010092-uftc8inx 3144 14 future future JJ cord-010092-uftc8inx 3144 15 clinical clinical JJ cord-010092-uftc8inx 3144 16 use use NN cord-010092-uftc8inx 3144 17 . . . cord-010092-uftc8inx 3145 1 I -PRON- PRP cord-010092-uftc8inx 3145 2 will will MD cord-010092-uftc8inx 3145 3 present present VB cord-010092-uftc8inx 3145 4 pre pre JJ cord-010092-uftc8inx 3145 5 - - JJ cord-010092-uftc8inx 3145 6 clinical clinical JJ cord-010092-uftc8inx 3145 7 work work NN cord-010092-uftc8inx 3145 8 on on IN cord-010092-uftc8inx 3145 9 developing develop VBG cord-010092-uftc8inx 3145 10 TIL TIL NNP cord-010092-uftc8inx 3145 11 therapy therapy NN cord-010092-uftc8inx 3145 12 for for IN cord-010092-uftc8inx 3145 13 non non JJ cord-010092-uftc8inx 3145 14 - - JJ cord-010092-uftc8inx 3145 15 small small JJ cord-010092-uftc8inx 3145 16 cell cell NN cord-010092-uftc8inx 3145 17 lung lung NN cord-010092-uftc8inx 3145 18 cancers cancer NNS cord-010092-uftc8inx 3145 19 . . . cord-010092-uftc8inx 3146 1 In in IN cord-010092-uftc8inx 3146 2 addition addition NN cord-010092-uftc8inx 3146 3 , , , cord-010092-uftc8inx 3146 4 I -PRON- PRP cord-010092-uftc8inx 3146 5 will will MD cord-010092-uftc8inx 3146 6 show show VB cord-010092-uftc8inx 3146 7 that that IN cord-010092-uftc8inx 3146 8 human human JJ cord-010092-uftc8inx 3146 9 CD8 CD8 NNP cord-010092-uftc8inx 3146 10 + + CC cord-010092-uftc8inx 3146 11 T T NNP cord-010092-uftc8inx 3146 12 cells cell NNS cord-010092-uftc8inx 3146 13 can can MD cord-010092-uftc8inx 3146 14 be be VB cord-010092-uftc8inx 3146 15 divided divide VBN cord-010092-uftc8inx 3146 16 into into IN cord-010092-uftc8inx 3146 17 different different JJ cord-010092-uftc8inx 3146 18 subsets subset NNS cord-010092-uftc8inx 3146 19 , , , cord-010092-uftc8inx 3146 20 and and CC cord-010092-uftc8inx 3146 21 that that IN cord-010092-uftc8inx 3146 22 only only RB cord-010092-uftc8inx 3146 23 one one CD cord-010092-uftc8inx 3146 24 of of IN cord-010092-uftc8inx 3146 25 those those DT cord-010092-uftc8inx 3146 26 subsets subset NNS cord-010092-uftc8inx 3146 27 is be VBZ cord-010092-uftc8inx 3146 28 highly highly RB cord-010092-uftc8inx 3146 29 cytotoxic cytotoxic JJ cord-010092-uftc8inx 3146 30 . . . cord-010092-uftc8inx 3147 1 This this DT cord-010092-uftc8inx 3147 2 finding finding NN cord-010092-uftc8inx 3147 3 may may MD cord-010092-uftc8inx 3147 4 help help VB cord-010092-uftc8inx 3147 5 improve improve VB cord-010092-uftc8inx 3147 6 the the DT cord-010092-uftc8inx 3147 7 quality quality NN cord-010092-uftc8inx 3147 8 of of IN cord-010092-uftc8inx 3147 9 genetically genetically RB cord-010092-uftc8inx 3147 10 engineered engineer VBN cord-010092-uftc8inx 3147 11 T t NN cord-010092-uftc8inx 3147 12 cell cell NN cord-010092-uftc8inx 3147 13 products product NNS cord-010092-uftc8inx 3147 14 , , , cord-010092-uftc8inx 3147 15 like like IN cord-010092-uftc8inx 3147 16 TCR TCR NNP cord-010092-uftc8inx 3147 17 and and CC cord-010092-uftc8inx 3147 18 CAR CAR NNP cord-010092-uftc8inx 3147 19 T T NNP cord-010092-uftc8inx 3147 20 cell cell NN cord-010092-uftc8inx 3147 21 products product NNS cord-010092-uftc8inx 3147 22 . . . cord-010092-uftc8inx 3148 1 Background background NN cord-010092-uftc8inx 3148 2 : : : cord-010092-uftc8inx 3149 1 The the DT cord-010092-uftc8inx 3149 2 Baltic Baltic NNP cord-010092-uftc8inx 3149 3 States States NNPS cord-010092-uftc8inx 3150 1 -Estonia -estonia UH cord-010092-uftc8inx 3150 2 , , , cord-010092-uftc8inx 3151 1 Latvia Latvia NNP cord-010092-uftc8inx 3151 2 and and CC cord-010092-uftc8inx 3151 3 Lithuania Lithuania NNP cord-010092-uftc8inx 3151 4 have have VBP cord-010092-uftc8inx 3151 5 a a DT cord-010092-uftc8inx 3151 6 lot lot NN cord-010092-uftc8inx 3151 7 in in IN cord-010092-uftc8inx 3151 8 common common JJ cord-010092-uftc8inx 3151 9 . . . cord-010092-uftc8inx 3152 1 We -PRON- PRP cord-010092-uftc8inx 3152 2 are be VBP cord-010092-uftc8inx 3152 3 located locate VBN cord-010092-uftc8inx 3152 4 side side NN cord-010092-uftc8inx 3152 5 by by IN cord-010092-uftc8inx 3152 6 side side NN cord-010092-uftc8inx 3152 7 , , , cord-010092-uftc8inx 3152 8 share share VB cord-010092-uftc8inx 3152 9 the the DT cord-010092-uftc8inx 3152 10 Baltic Baltic NNP cord-010092-uftc8inx 3152 11 Sea Sea NNP cord-010092-uftc8inx 3152 12 as as IN cord-010092-uftc8inx 3152 13 a a DT cord-010092-uftc8inx 3152 14 gate gate NN cord-010092-uftc8inx 3152 15 to to IN cord-010092-uftc8inx 3152 16 the the DT cord-010092-uftc8inx 3152 17 West West NNP cord-010092-uftc8inx 3152 18 , , , cord-010092-uftc8inx 3152 19 and and CC cord-010092-uftc8inx 3152 20 more more RBR cord-010092-uftc8inx 3152 21 importantly importantly RB cord-010092-uftc8inx 3152 22 , , , cord-010092-uftc8inx 3152 23 a a DT cord-010092-uftc8inx 3152 24 common common JJ cord-010092-uftc8inx 3152 25 history history NN cord-010092-uftc8inx 3152 26 . . . cord-010092-uftc8inx 3153 1 We -PRON- PRP cord-010092-uftc8inx 3153 2 were be VBD cord-010092-uftc8inx 3153 3 members member NNS cord-010092-uftc8inx 3153 4 of of IN cord-010092-uftc8inx 3153 5 the the DT cord-010092-uftc8inx 3153 6 USSR USSR NNP cord-010092-uftc8inx 3153 7 and and CC cord-010092-uftc8inx 3153 8 suffered suffer VBD cord-010092-uftc8inx 3153 9 50 50 CD cord-010092-uftc8inx 3153 10 years year NNS cord-010092-uftc8inx 3153 11 of of IN cord-010092-uftc8inx 3153 12 Soviet soviet JJ cord-010092-uftc8inx 3153 13 occupation occupation NN cord-010092-uftc8inx 3153 14 . . . cord-010092-uftc8inx 3154 1 We -PRON- PRP cord-010092-uftc8inx 3154 2 held hold VBD cord-010092-uftc8inx 3154 3 hands hand NNS cord-010092-uftc8inx 3154 4 in in IN cord-010092-uftc8inx 3154 5 a a DT cord-010092-uftc8inx 3154 6 600 600 CD cord-010092-uftc8inx 3154 7 km km NN cord-010092-uftc8inx 3154 8 long long JJ cord-010092-uftc8inx 3154 9 human human NN cord-010092-uftc8inx 3154 10 . . . cord-010092-uftc8inx 3154 11 . . . cord-010092-uftc8inx 3154 12 .chain .chain . cord-010092-uftc8inx 3155 1 " " `` cord-010092-uftc8inx 3155 2 across across IN cord-010092-uftc8inx 3155 3 the the DT cord-010092-uftc8inx 3155 4 three three CD cord-010092-uftc8inx 3155 5 States States NNPS cord-010092-uftc8inx 3155 6 to to TO cord-010092-uftc8inx 3155 7 express express VB cord-010092-uftc8inx 3155 8 our -PRON- PRP$ cord-010092-uftc8inx 3155 9 mutual mutual JJ cord-010092-uftc8inx 3155 10 support support NN cord-010092-uftc8inx 3155 11 , , , cord-010092-uftc8inx 3155 12 and and CC cord-010092-uftc8inx 3155 13 later later RB cord-010092-uftc8inx 3155 14 on on RB cord-010092-uftc8inx 3155 15 , , , cord-010092-uftc8inx 3155 16 even even RB cord-010092-uftc8inx 3155 17 joined join VBD cord-010092-uftc8inx 3155 18 the the DT cord-010092-uftc8inx 3155 19 European European NNP cord-010092-uftc8inx 3155 20 Union Union NNP cord-010092-uftc8inx 3155 21 on on IN cord-010092-uftc8inx 3155 22 the the DT cord-010092-uftc8inx 3155 23 very very RB cord-010092-uftc8inx 3155 24 same same JJ cord-010092-uftc8inx 3155 25 day day NN cord-010092-uftc8inx 3155 26 -June -June NNP cord-010092-uftc8inx 3155 27 1 1 CD cord-010092-uftc8inx 3155 28 st st NNP cord-010092-uftc8inx 3155 29 , , , cord-010092-uftc8inx 3155 30 2004 2004 CD cord-010092-uftc8inx 3155 31 . . . cord-010092-uftc8inx 3156 1 The the DT cord-010092-uftc8inx 3156 2 three three CD cord-010092-uftc8inx 3156 3 differ differ VBP cord-010092-uftc8inx 3156 4 a a DT cord-010092-uftc8inx 3156 5 bit bit NN cord-010092-uftc8inx 3156 6 in in IN cord-010092-uftc8inx 3156 7 size size NN cord-010092-uftc8inx 3156 8 , , , cord-010092-uftc8inx 3156 9 population population NN cord-010092-uftc8inx 3156 10 and and CC cord-010092-uftc8inx 3156 11 more more JJR cord-010092-uftc8inx 3156 12 in in IN cord-010092-uftc8inx 3156 13 the the DT cord-010092-uftc8inx 3156 14 languages language NNS cord-010092-uftc8inx 3156 15 spoken speak VBN cord-010092-uftc8inx 3156 16 in in IN cord-010092-uftc8inx 3156 17 each each DT cord-010092-uftc8inx 3156 18 one one NN cord-010092-uftc8inx 3156 19 , , , cord-010092-uftc8inx 3156 20 but but CC cord-010092-uftc8inx 3156 21 that that DT cord-010092-uftc8inx 3156 22 does do VBZ cord-010092-uftc8inx 3156 23 not not RB cord-010092-uftc8inx 3156 24 explain explain VB cord-010092-uftc8inx 3156 25 why why WRB cord-010092-uftc8inx 3156 26 the the DT cord-010092-uftc8inx 3156 27 path path NN cord-010092-uftc8inx 3156 28 towards towards IN cord-010092-uftc8inx 3156 29 voluntary voluntary JJ cord-010092-uftc8inx 3156 30 unpaid unpaid JJ cord-010092-uftc8inx 3156 31 donation donation NN cord-010092-uftc8inx 3156 32 varies vary VBZ cord-010092-uftc8inx 3156 33 as as IN cord-010092-uftc8inx 3156 34 it -PRON- PRP cord-010092-uftc8inx 3156 35 does do VBZ cord-010092-uftc8inx 3156 36 . . . cord-010092-uftc8inx 3157 1 Aim aim VB cord-010092-uftc8inx 3157 2 : : : cord-010092-uftc8inx 3157 3 The the DT cord-010092-uftc8inx 3157 4 aim aim NN cord-010092-uftc8inx 3157 5 is be VBZ cord-010092-uftc8inx 3157 6 to to TO cord-010092-uftc8inx 3157 7 describe describe VB cord-010092-uftc8inx 3157 8 the the DT cord-010092-uftc8inx 3157 9 journey journey NN cord-010092-uftc8inx 3157 10 towards towards IN cord-010092-uftc8inx 3157 11 voluntary voluntary JJ cord-010092-uftc8inx 3157 12 non non JJ cord-010092-uftc8inx 3157 13 - - JJ cord-010092-uftc8inx 3157 14 remunerated remunerated JJ cord-010092-uftc8inx 3157 15 blood blood NN cord-010092-uftc8inx 3157 16 donation donation NN cord-010092-uftc8inx 3157 17 in in IN cord-010092-uftc8inx 3157 18 the the DT cord-010092-uftc8inx 3157 19 Baltic Baltic NNP cord-010092-uftc8inx 3157 20 States States NNP cord-010092-uftc8inx 3157 21 after after IN cord-010092-uftc8inx 3157 22 regaining regain VBG cord-010092-uftc8inx 3157 23 independence independence NN cord-010092-uftc8inx 3157 24 from from IN cord-010092-uftc8inx 3157 25 the the DT cord-010092-uftc8inx 3157 26 Soviet Soviet NNP cord-010092-uftc8inx 3157 27 Union Union NNP cord-010092-uftc8inx 3157 28 . . . cord-010092-uftc8inx 3158 1 Methods method NNS cord-010092-uftc8inx 3158 2 : : : cord-010092-uftc8inx 3158 3 The the DT cord-010092-uftc8inx 3158 4 information information NN cord-010092-uftc8inx 3158 5 was be VBD cord-010092-uftc8inx 3158 6 collected collect VBN cord-010092-uftc8inx 3158 7 from from IN cord-010092-uftc8inx 3158 8 published publish VBN cord-010092-uftc8inx 3158 9 and and CC cord-010092-uftc8inx 3158 10 unpublished unpublished JJ cord-010092-uftc8inx 3158 11 memories memory NNS cord-010092-uftc8inx 3158 12 , , , cord-010092-uftc8inx 3158 13 annual annual JJ cord-010092-uftc8inx 3158 14 reports report NNS cord-010092-uftc8inx 3158 15 and and CC cord-010092-uftc8inx 3158 16 written write VBN cord-010092-uftc8inx 3158 17 interviews interview NNS cord-010092-uftc8inx 3158 18 with with IN cord-010092-uftc8inx 3158 19 Latvian latvian JJ cord-010092-uftc8inx 3158 20 and and CC cord-010092-uftc8inx 3158 21 Lithuanian lithuanian JJ cord-010092-uftc8inx 3158 22 colleagues colleague NNS cord-010092-uftc8inx 3158 23 . . . cord-010092-uftc8inx 3159 1 Results result NNS cord-010092-uftc8inx 3159 2 : : : cord-010092-uftc8inx 3160 1 In in IN cord-010092-uftc8inx 3160 2 Soviet soviet JJ cord-010092-uftc8inx 3160 3 times time NNS cord-010092-uftc8inx 3160 4 , , , cord-010092-uftc8inx 3160 5 all all DT cord-010092-uftc8inx 3160 6 orders order NNS cord-010092-uftc8inx 3160 7 came come VBD cord-010092-uftc8inx 3160 8 from from IN cord-010092-uftc8inx 3160 9 Moscow Moscow NNP cord-010092-uftc8inx 3160 10 and and CC cord-010092-uftc8inx 3160 11 quality quality NN cord-010092-uftc8inx 3160 12 control control NN cord-010092-uftc8inx 3160 13 was be VBD cord-010092-uftc8inx 3160 14 conducted conduct VBN cord-010092-uftc8inx 3160 15 from from IN cord-010092-uftc8inx 3160 16 the the DT cord-010092-uftc8inx 3160 17 capital capital NN cord-010092-uftc8inx 3160 18 city city NN cord-010092-uftc8inx 3160 19 of of IN cord-010092-uftc8inx 3160 20 Latvia Latvia NNP cord-010092-uftc8inx 3160 21 , , , cord-010092-uftc8inx 3160 22 Riga Riga NNP cord-010092-uftc8inx 3160 23 . . . cord-010092-uftc8inx 3161 1 Donors donor NNS cord-010092-uftc8inx 3161 2 were be VBD cord-010092-uftc8inx 3161 3 mostly mostly RB cord-010092-uftc8inx 3161 4 paid pay VBN cord-010092-uftc8inx 3161 5 and and CC cord-010092-uftc8inx 3161 6 given give VBN cord-010092-uftc8inx 3161 7 an an DT cord-010092-uftc8inx 3161 8 extra extra JJ cord-010092-uftc8inx 3161 9 vacation vacation NN cord-010092-uftc8inx 3161 10 day day NN cord-010092-uftc8inx 3161 11 . . . cord-010092-uftc8inx 3162 1 Big big JJ cord-010092-uftc8inx 3162 2 factories factory NNS cord-010092-uftc8inx 3162 3 were be VBD cord-010092-uftc8inx 3162 4 the the DT cord-010092-uftc8inx 3162 5 best good JJS cord-010092-uftc8inx 3162 6 places place NNS cord-010092-uftc8inx 3162 7 to to TO cord-010092-uftc8inx 3162 8 collect collect VB cord-010092-uftc8inx 3162 9 blood blood NN cord-010092-uftc8inx 3162 10 and and CC cord-010092-uftc8inx 3162 11 people people NNS cord-010092-uftc8inx 3162 12 were be VBD cord-010092-uftc8inx 3162 13 queuing queue VBG cord-010092-uftc8inx 3162 14 to to TO cord-010092-uftc8inx 3162 15 donate donate VB cord-010092-uftc8inx 3162 16 . . . cord-010092-uftc8inx 3163 1 In in IN cord-010092-uftc8inx 3163 2 1991 1991 CD cord-010092-uftc8inx 3163 3 , , , cord-010092-uftc8inx 3163 4 the the DT cord-010092-uftc8inx 3163 5 Soviet Soviet NNP cord-010092-uftc8inx 3163 6 Union Union NNP cord-010092-uftc8inx 3163 7 fell fall VBD cord-010092-uftc8inx 3163 8 apart apart RB cord-010092-uftc8inx 3163 9 and and CC cord-010092-uftc8inx 3163 10 the the DT cord-010092-uftc8inx 3163 11 Baltic Baltic NNP cord-010092-uftc8inx 3163 12 States States NNP cord-010092-uftc8inx 3163 13 suddenly suddenly RB cord-010092-uftc8inx 3163 14 got get VBD cord-010092-uftc8inx 3163 15 the the DT cord-010092-uftc8inx 3163 16 freedom freedom NN cord-010092-uftc8inx 3163 17 and and CC cord-010092-uftc8inx 3163 18 responsibility responsibility NN cord-010092-uftc8inx 3163 19 to to TO cord-010092-uftc8inx 3163 20 decide decide VB cord-010092-uftc8inx 3163 21 . . . cord-010092-uftc8inx 3164 1 In in IN cord-010092-uftc8inx 3164 2 Estonia Estonia NNP cord-010092-uftc8inx 3164 3 the the DT cord-010092-uftc8inx 3164 4 first first JJ cord-010092-uftc8inx 3164 5 edition edition NN cord-010092-uftc8inx 3164 6 of of IN cord-010092-uftc8inx 3164 7 " " `` cord-010092-uftc8inx 3164 8 Guidelines Guidelines NNPS cord-010092-uftc8inx 3164 9 for for IN cord-010092-uftc8inx 3164 10 the the DT cord-010092-uftc8inx 3164 11 Preparation preparation NN cord-010092-uftc8inx 3164 12 , , , cord-010092-uftc8inx 3164 13 Use Use NNP cord-010092-uftc8inx 3164 14 and and CC cord-010092-uftc8inx 3164 15 Quality Quality NNP cord-010092-uftc8inx 3164 16 Assurance Assurance NNP cord-010092-uftc8inx 3164 17 of of IN cord-010092-uftc8inx 3164 18 Blood Blood NNP cord-010092-uftc8inx 3164 19 Components Components NNP cord-010092-uftc8inx 3164 20 " " '' cord-010092-uftc8inx 3164 21 was be VBD cord-010092-uftc8inx 3164 22 taken take VBN cord-010092-uftc8inx 3164 23 as as IN cord-010092-uftc8inx 3164 24 guidance guidance NN cord-010092-uftc8inx 3164 25 in in IN cord-010092-uftc8inx 3164 26 1992 1992 CD cord-010092-uftc8inx 3164 27 . . . cord-010092-uftc8inx 3165 1 A a DT cord-010092-uftc8inx 3165 2 lot lot NN cord-010092-uftc8inx 3165 3 of of IN cord-010092-uftc8inx 3165 4 advice advice NN cord-010092-uftc8inx 3165 5 came come VBD cord-010092-uftc8inx 3165 6 from from IN cord-010092-uftc8inx 3165 7 Finnish finnish JJ cord-010092-uftc8inx 3165 8 colleagues colleague NNS cord-010092-uftc8inx 3165 9 . . . cord-010092-uftc8inx 3166 1 In in IN cord-010092-uftc8inx 3166 2 1997 1997 CD cord-010092-uftc8inx 3166 3 , , , cord-010092-uftc8inx 3166 4 it -PRON- PRP cord-010092-uftc8inx 3166 5 was be VBD cord-010092-uftc8inx 3166 6 decided decide VBN cord-010092-uftc8inx 3166 7 to to TO cord-010092-uftc8inx 3166 8 move move VB cord-010092-uftc8inx 3166 9 towards towards IN cord-010092-uftc8inx 3166 10 non non JJ cord-010092-uftc8inx 3166 11 - - JJ cord-010092-uftc8inx 3166 12 paid pay VBN cord-010092-uftc8inx 3166 13 voluntary voluntary JJ cord-010092-uftc8inx 3166 14 donations donation NNS cord-010092-uftc8inx 3166 15 . . . cord-010092-uftc8inx 3167 1 The the DT cord-010092-uftc8inx 3167 2 process process NN cord-010092-uftc8inx 3167 3 took take VBD cord-010092-uftc8inx 3167 4 6 6 CD cord-010092-uftc8inx 3167 5 years year NNS cord-010092-uftc8inx 3167 6 . . . cord-010092-uftc8inx 3168 1 The the DT cord-010092-uftc8inx 3168 2 first first JJ cord-010092-uftc8inx 3168 3 couple couple NN cord-010092-uftc8inx 3168 4 of of IN cord-010092-uftc8inx 3168 5 years year NNS cord-010092-uftc8inx 3168 6 were be VBD cord-010092-uftc8inx 3168 7 economically economically RB cord-010092-uftc8inx 3168 8 difficult difficult JJ cord-010092-uftc8inx 3168 9 for for IN cord-010092-uftc8inx 3168 10 the the DT cord-010092-uftc8inx 3168 11 reborn reborn VBN cord-010092-uftc8inx 3168 12 state state NN cord-010092-uftc8inx 3168 13 , , , cord-010092-uftc8inx 3168 14 as as IN cord-010092-uftc8inx 3168 15 money money NN cord-010092-uftc8inx 3168 16 had have VBD cord-010092-uftc8inx 3168 17 less less JJR cord-010092-uftc8inx 3168 18 value value NN cord-010092-uftc8inx 3168 19 than than IN cord-010092-uftc8inx 3168 20 food food NN cord-010092-uftc8inx 3168 21 . . . cord-010092-uftc8inx 3169 1 Instead instead RB cord-010092-uftc8inx 3169 2 of of IN cord-010092-uftc8inx 3169 3 cash cash NN cord-010092-uftc8inx 3169 4 , , , cord-010092-uftc8inx 3169 5 donors donor NNS cord-010092-uftc8inx 3169 6 were be VBD cord-010092-uftc8inx 3169 7 given give VBN cord-010092-uftc8inx 3169 8 rapeseed rapeseed NN cord-010092-uftc8inx 3169 9 oil oil NN cord-010092-uftc8inx 3169 10 , , , cord-010092-uftc8inx 3169 11 sugar sugar NN cord-010092-uftc8inx 3169 12 and and CC cord-010092-uftc8inx 3169 13 pasta pasta NN cord-010092-uftc8inx 3169 14 , , , cord-010092-uftc8inx 3169 15 for for IN cord-010092-uftc8inx 3169 16 example example NN cord-010092-uftc8inx 3169 17 . . . cord-010092-uftc8inx 3170 1 As as IN cord-010092-uftc8inx 3170 2 the the DT cord-010092-uftc8inx 3170 3 situation situation NN cord-010092-uftc8inx 3170 4 improved improve VBN cord-010092-uftc8inx 3170 5 , , , cord-010092-uftc8inx 3170 6 food food NN cord-010092-uftc8inx 3170 7 items item NNS cord-010092-uftc8inx 3170 8 were be VBD cord-010092-uftc8inx 3170 9 replaced replace VBN cord-010092-uftc8inx 3170 10 by by IN cord-010092-uftc8inx 3170 11 small small JJ cord-010092-uftc8inx 3170 12 symbolic symbolic JJ cord-010092-uftc8inx 3170 13 gifts gift NNS cord-010092-uftc8inx 3170 14 that that WDT cord-010092-uftc8inx 3170 15 carry carry VBP cord-010092-uftc8inx 3170 16 sentimental sentimental JJ cord-010092-uftc8inx 3170 17 value value NN cord-010092-uftc8inx 3170 18 . . . cord-010092-uftc8inx 3171 1 It -PRON- PRP cord-010092-uftc8inx 3171 2 has have VBZ cord-010092-uftc8inx 3171 3 been be VBN cord-010092-uftc8inx 3171 4 this this DT cord-010092-uftc8inx 3171 5 way way NN cord-010092-uftc8inx 3171 6 for for IN cord-010092-uftc8inx 3171 7 more more JJR cord-010092-uftc8inx 3171 8 than than IN cord-010092-uftc8inx 3171 9 15 15 CD cord-010092-uftc8inx 3171 10 years year NNS cord-010092-uftc8inx 3171 11 by by IN cord-010092-uftc8inx 3171 12 now now RB cord-010092-uftc8inx 3171 13 . . . cord-010092-uftc8inx 3172 1 In in IN cord-010092-uftc8inx 3172 2 Lithuania Lithuania NNP cord-010092-uftc8inx 3172 3 , , , cord-010092-uftc8inx 3172 4 the the DT cord-010092-uftc8inx 3172 5 process process NN cord-010092-uftc8inx 3172 6 started start VBD cord-010092-uftc8inx 3172 7 later later RB cord-010092-uftc8inx 3172 8 , , , cord-010092-uftc8inx 3172 9 the the DT cord-010092-uftc8inx 3172 10 first first JJ cord-010092-uftc8inx 3172 11 program program NN cord-010092-uftc8inx 3172 12 for for IN cord-010092-uftc8inx 3172 13 developing develop VBG cord-010092-uftc8inx 3172 14 a a DT cord-010092-uftc8inx 3172 15 framework framework NN cord-010092-uftc8inx 3172 16 for for IN cord-010092-uftc8inx 3172 17 voluntary voluntary JJ cord-010092-uftc8inx 3172 18 non non JJ cord-010092-uftc8inx 3172 19 - - JJ cord-010092-uftc8inx 3172 20 remunerated remunerated JJ cord-010092-uftc8inx 3172 21 donations donation NNS cord-010092-uftc8inx 3172 22 being be VBG cord-010092-uftc8inx 3172 23 carried carry VBN cord-010092-uftc8inx 3172 24 out out RP cord-010092-uftc8inx 3172 25 in in IN cord-010092-uftc8inx 3172 26 2006 2006 CD cord-010092-uftc8inx 3172 27 - - SYM cord-010092-uftc8inx 3172 28 2015 2015 CD cord-010092-uftc8inx 3172 29 . . . cord-010092-uftc8inx 3173 1 It -PRON- PRP cord-010092-uftc8inx 3173 2 resulted result VBD cord-010092-uftc8inx 3173 3 in in IN cord-010092-uftc8inx 3173 4 51 51 CD cord-010092-uftc8inx 3173 5 % % NN cord-010092-uftc8inx 3173 6 of of IN cord-010092-uftc8inx 3173 7 the the DT cord-010092-uftc8inx 3173 8 donations donation NNS cord-010092-uftc8inx 3173 9 being be VBG cord-010092-uftc8inx 3173 10 unpaid unpaid JJ cord-010092-uftc8inx 3173 11 . . . cord-010092-uftc8inx 3174 1 The the DT cord-010092-uftc8inx 3174 2 second second JJ cord-010092-uftc8inx 3174 3 program program NN cord-010092-uftc8inx 3174 4 initiated initiate VBN cord-010092-uftc8inx 3174 5 in in IN cord-010092-uftc8inx 3174 6 2016 2016 CD cord-010092-uftc8inx 3174 7 is be VBZ cord-010092-uftc8inx 3174 8 still still RB cord-010092-uftc8inx 3174 9 ongoing ongoing JJ cord-010092-uftc8inx 3174 10 , , , cord-010092-uftc8inx 3174 11 aiming aim VBG cord-010092-uftc8inx 3174 12 towards towards IN cord-010092-uftc8inx 3174 13 100 100 CD cord-010092-uftc8inx 3174 14 % % NN cord-010092-uftc8inx 3174 15 non non JJ cord-010092-uftc8inx 3174 16 - - JJ cord-010092-uftc8inx 3174 17 remunerated remunerated JJ cord-010092-uftc8inx 3174 18 donations donation NNS cord-010092-uftc8inx 3174 19 by by IN cord-010092-uftc8inx 3174 20 2020 2020 CD cord-010092-uftc8inx 3174 21 . . . cord-010092-uftc8inx 3175 1 By by IN cord-010092-uftc8inx 3175 2 the the DT cord-010092-uftc8inx 3175 3 end end NN cord-010092-uftc8inx 3175 4 of of IN cord-010092-uftc8inx 3175 5 2018 2018 CD cord-010092-uftc8inx 3175 6 , , , cord-010092-uftc8inx 3175 7 they -PRON- PRP cord-010092-uftc8inx 3175 8 had have VBD cord-010092-uftc8inx 3175 9 reached reach VBN cord-010092-uftc8inx 3175 10 99.2 99.2 CD cord-010092-uftc8inx 3175 11 % % NN cord-010092-uftc8inx 3175 12 . . . cord-010092-uftc8inx 3176 1 In in IN cord-010092-uftc8inx 3176 2 the the DT cord-010092-uftc8inx 3176 3 beginning beginning NN cord-010092-uftc8inx 3176 4 , , , cord-010092-uftc8inx 3176 5 the the DT cord-010092-uftc8inx 3176 6 main main JJ cord-010092-uftc8inx 3176 7 obstacle obstacle NN cord-010092-uftc8inx 3176 8 was be VBD cord-010092-uftc8inx 3176 9 a a DT cord-010092-uftc8inx 3176 10 private private JJ cord-010092-uftc8inx 3176 11 blood blood NN cord-010092-uftc8inx 3176 12 center center NN cord-010092-uftc8inx 3176 13 creating create VBG cord-010092-uftc8inx 3176 14 unfair unfair JJ cord-010092-uftc8inx 3176 15 market market NN cord-010092-uftc8inx 3176 16 conditions condition NNS cord-010092-uftc8inx 3176 17 . . . cord-010092-uftc8inx 3177 1 In in IN cord-010092-uftc8inx 3177 2 Latvia Latvia NNP cord-010092-uftc8inx 3177 3 , , , cord-010092-uftc8inx 3177 4 monetary monetary JJ cord-010092-uftc8inx 3177 5 compensation compensation NN cord-010092-uftc8inx 3177 6 for for IN cord-010092-uftc8inx 3177 7 blood blood NN cord-010092-uftc8inx 3177 8 donations donation NNS cord-010092-uftc8inx 3177 9 still still RB cord-010092-uftc8inx 3177 10 exists exist VBZ cord-010092-uftc8inx 3177 11 , , , cord-010092-uftc8inx 3177 12 but but CC cord-010092-uftc8inx 3177 13 the the DT cord-010092-uftc8inx 3177 14 younger young JJR cord-010092-uftc8inx 3177 15 generation generation NN cord-010092-uftc8inx 3177 16 has have VBZ cord-010092-uftc8inx 3177 17 been be VBN cord-010092-uftc8inx 3177 18 encouraged encourage VBN cord-010092-uftc8inx 3177 19 to to TO cord-010092-uftc8inx 3177 20 donate donate VB cord-010092-uftc8inx 3177 21 blood blood NN cord-010092-uftc8inx 3177 22 for for IN cord-010092-uftc8inx 3177 23 free free JJ cord-010092-uftc8inx 3177 24 and and CC cord-010092-uftc8inx 3177 25 some some DT cord-010092-uftc8inx 3177 26 results result NNS cord-010092-uftc8inx 3177 27 can can MD cord-010092-uftc8inx 3177 28 already already RB cord-010092-uftc8inx 3177 29 be be VB cord-010092-uftc8inx 3177 30 seen see VBN cord-010092-uftc8inx 3177 31 . . . cord-010092-uftc8inx 3178 1 Summary Summary NNP cord-010092-uftc8inx 3178 2 / / SYM cord-010092-uftc8inx 3178 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 3178 4 : : : cord-010092-uftc8inx 3179 1 A a DT cord-010092-uftc8inx 3179 2 common common JJ cord-010092-uftc8inx 3179 3 starting starting NN cord-010092-uftc8inx 3179 4 point point NN cord-010092-uftc8inx 3179 5 does do VBZ cord-010092-uftc8inx 3179 6 not not RB cord-010092-uftc8inx 3179 7 guarantee guarantee VB cord-010092-uftc8inx 3179 8 the the DT cord-010092-uftc8inx 3179 9 same same JJ cord-010092-uftc8inx 3179 10 results result NNS cord-010092-uftc8inx 3179 11 , , , cord-010092-uftc8inx 3179 12 at at IN cord-010092-uftc8inx 3179 13 least least JJS cord-010092-uftc8inx 3179 14 not not RB cord-010092-uftc8inx 3179 15 at at IN cord-010092-uftc8inx 3179 16 the the DT cord-010092-uftc8inx 3179 17 exact exact JJ cord-010092-uftc8inx 3179 18 same same JJ cord-010092-uftc8inx 3179 19 time time NN cord-010092-uftc8inx 3179 20 . . . cord-010092-uftc8inx 3180 1 Examining examine VBG cord-010092-uftc8inx 3180 2 the the DT cord-010092-uftc8inx 3180 3 circumstances circumstance NNS cord-010092-uftc8inx 3180 4 leading lead VBG cord-010092-uftc8inx 3180 5 to to IN cord-010092-uftc8inx 3180 6 the the DT cord-010092-uftc8inx 3180 7 different different JJ cord-010092-uftc8inx 3180 8 outcomes outcome NNS cord-010092-uftc8inx 3180 9 could could MD cord-010092-uftc8inx 3180 10 benefit benefit VB cord-010092-uftc8inx 3180 11 countries country NNS cord-010092-uftc8inx 3180 12 yet yet RB cord-010092-uftc8inx 3180 13 to to TO cord-010092-uftc8inx 3180 14 start start VB cord-010092-uftc8inx 3180 15 moving move VBG cord-010092-uftc8inx 3180 16 towards towards IN cord-010092-uftc8inx 3180 17 non non JJ cord-010092-uftc8inx 3180 18 - - JJ cord-010092-uftc8inx 3180 19 remunerated remunerated JJ cord-010092-uftc8inx 3180 20 donations donation NNS cord-010092-uftc8inx 3180 21 as as RB cord-010092-uftc8inx 3180 22 well well RB cord-010092-uftc8inx 3180 23 as as IN cord-010092-uftc8inx 3180 24 those those DT cord-010092-uftc8inx 3180 25 considering consider VBG cord-010092-uftc8inx 3180 26 the the DT cord-010092-uftc8inx 3180 27 opposite opposite NN cord-010092-uftc8inx 3180 28 . . . cord-010092-uftc8inx 3181 1 Haemoglobin haemoglobin NN cord-010092-uftc8inx 3181 2 ( ( -LRB- cord-010092-uftc8inx 3181 3 Hb Hb NNP cord-010092-uftc8inx 3181 4 ) ) -RRB- cord-010092-uftc8inx 3181 5 was be VBD cord-010092-uftc8inx 3181 6 as as IN cord-010092-uftc8inx 3181 7 expected expect VBN cord-010092-uftc8inx 3181 8 significantly significantly RB cord-010092-uftc8inx 3181 9 different different JJ cord-010092-uftc8inx 3181 10 between between IN cord-010092-uftc8inx 3181 11 women woman NNS cord-010092-uftc8inx 3181 12 and and CC cord-010092-uftc8inx 3181 13 men man NNS cord-010092-uftc8inx 3181 14 ( ( -LRB- cord-010092-uftc8inx 3181 15 meanAESEM meanAESEM NNP cord-010092-uftc8inx 3181 16 : : : cord-010092-uftc8inx 3181 17 13.8 13.8 CD cord-010092-uftc8inx 3181 18 AE AE NNP cord-010092-uftc8inx 3181 19 0.01 0.01 CD cord-010092-uftc8inx 3181 20 vs vs IN cord-010092-uftc8inx 3181 21 15.5 15.5 CD cord-010092-uftc8inx 3181 22 AE AE NNP cord-010092-uftc8inx 3181 23 0.01 0.01 CD cord-010092-uftc8inx 3181 24 g g NN cord-010092-uftc8inx 3181 25 / / SYM cord-010092-uftc8inx 3181 26 dl dl NN cord-010092-uftc8inx 3181 27 ; ; : cord-010092-uftc8inx 3181 28 P p NN cord-010092-uftc8inx 3181 29 < < XX cord-010092-uftc8inx 3181 30 0.000 0.000 CD cord-010092-uftc8inx 3181 31 ) ) -RRB- cord-010092-uftc8inx 3181 32 . . . cord-010092-uftc8inx 3182 1 Percentage percentage NN cord-010092-uftc8inx 3182 2 of of IN cord-010092-uftc8inx 3182 3 females female NNS cord-010092-uftc8inx 3182 4 with with IN cord-010092-uftc8inx 3182 5 low low JJ cord-010092-uftc8inx 3182 6 Hb Hb NNP cord-010092-uftc8inx 3182 7 < < XX cord-010092-uftc8inx 3182 8 12.5 12.5 CD cord-010092-uftc8inx 3182 9 g g NN cord-010092-uftc8inx 3182 10 / / SYM cord-010092-uftc8inx 3182 11 dl dl NNP cord-010092-uftc8inx 3182 12 were be VBD cord-010092-uftc8inx 3182 13 7.1 7.1 CD cord-010092-uftc8inx 3182 14 % % NN cord-010092-uftc8inx 3182 15 , , , cord-010092-uftc8inx 3182 16 4.9 4.9 CD cord-010092-uftc8inx 3182 17 % % NN cord-010092-uftc8inx 3182 18 , , , cord-010092-uftc8inx 3182 19 5.2 5.2 CD cord-010092-uftc8inx 3182 20 % % NN cord-010092-uftc8inx 3182 21 , , , cord-010092-uftc8inx 3182 22 6.7 6.7 CD cord-010092-uftc8inx 3182 23 % % NN cord-010092-uftc8inx 3182 24 and and CC cord-010092-uftc8inx 3182 25 4.2 4.2 CD cord-010092-uftc8inx 3182 26 % % NN cord-010092-uftc8inx 3182 27 , , , cord-010092-uftc8inx 3182 28 percentage percentage NN cord-010092-uftc8inx 3182 29 of of IN cord-010092-uftc8inx 3182 30 males male NNS cord-010092-uftc8inx 3182 31 with with IN cord-010092-uftc8inx 3182 32 Hb Hb NNP cord-010092-uftc8inx 3182 33 < < XX cord-010092-uftc8inx 3182 34 13.5 13.5 CD cord-010092-uftc8inx 3182 35 g g NN cord-010092-uftc8inx 3182 36 / / SYM cord-010092-uftc8inx 3182 37 dl dl NN cord-010092-uftc8inx 3183 1 were be VBD cord-010092-uftc8inx 3183 2 0.5 0.5 CD cord-010092-uftc8inx 3183 3 % % NN cord-010092-uftc8inx 3183 4 , , , cord-010092-uftc8inx 3183 5 0.6 0.6 CD cord-010092-uftc8inx 3183 6 % % NN cord-010092-uftc8inx 3183 7 , , , cord-010092-uftc8inx 3183 8 0.7 0.7 CD cord-010092-uftc8inx 3183 9 % % NN cord-010092-uftc8inx 3183 10 , , , cord-010092-uftc8inx 3183 11 1.7 1.7 CD cord-010092-uftc8inx 3183 12 % % NN cord-010092-uftc8inx 3183 13 and and CC cord-010092-uftc8inx 3183 14 1.2 1.2 CD cord-010092-uftc8inx 3183 15 % % NN cord-010092-uftc8inx 3183 16 for for IN cord-010092-uftc8inx 3183 17 the the DT cord-010092-uftc8inx 3183 18 age age NN cord-010092-uftc8inx 3183 19 groups group NNS cord-010092-uftc8inx 3183 20 1 1 CD cord-010092-uftc8inx 3183 21 - - SYM cord-010092-uftc8inx 3183 22 5 5 CD cord-010092-uftc8inx 3183 23 respectively respectively RB cord-010092-uftc8inx 3183 24 . . . cord-010092-uftc8inx 3184 1 Ferritin ferritin NN cord-010092-uftc8inx 3184 2 values value NNS cord-010092-uftc8inx 3184 3 were be VBD cord-010092-uftc8inx 3184 4 higher high JJR cord-010092-uftc8inx 3184 5 in in IN cord-010092-uftc8inx 3184 6 males male NNS cord-010092-uftc8inx 3184 7 compared compare VBN cord-010092-uftc8inx 3184 8 to to IN cord-010092-uftc8inx 3184 9 females female NNS cord-010092-uftc8inx 3184 10 ( ( -LRB- cord-010092-uftc8inx 3184 11 median median NN cord-010092-uftc8inx 3184 12 ; ; : cord-010092-uftc8inx 3184 13 25 25 CD cord-010092-uftc8inx 3184 14 th th XX cord-010092-uftc8inx 3184 15 -75 -75 NN cord-010092-uftc8inx 3184 16 th th XX cord-010092-uftc8inx 3184 17 % % NN cord-010092-uftc8inx 3184 18 > > XX cord-010092-uftc8inx 3184 19 tile tile NN cord-010092-uftc8inx 3184 20 : : : cord-010092-uftc8inx 3184 21 51;31 51;31 CD cord-010092-uftc8inx 3184 22 - - SYM cord-010092-uftc8inx 3184 23 79 79 CD cord-010092-uftc8inx 3184 24 vs vs IN cord-010092-uftc8inx 3184 25 157;106 157;106 CD cord-010092-uftc8inx 3184 26 - - SYM cord-010092-uftc8inx 3184 27 231 231 CD cord-010092-uftc8inx 3184 28 lg lg NNP cord-010092-uftc8inx 3184 29 / / SYM cord-010092-uftc8inx 3184 30 l l NN cord-010092-uftc8inx 3184 31 ; ; : cord-010092-uftc8inx 3184 32 P p NN cord-010092-uftc8inx 3184 33 < < XX cord-010092-uftc8inx 3184 34 0.000 0.000 CD cord-010092-uftc8inx 3184 35 ) ) -RRB- cord-010092-uftc8inx 3184 36 and and CC cord-010092-uftc8inx 3184 37 in in IN cord-010092-uftc8inx 3184 38 older old JJR cord-010092-uftc8inx 3184 39 age age NN cord-010092-uftc8inx 3184 40 groups group NNS cord-010092-uftc8inx 3184 41 compared compare VBN cord-010092-uftc8inx 3184 42 to to IN cord-010092-uftc8inx 3184 43 younger young JJR cord-010092-uftc8inx 3184 44 age age NN cord-010092-uftc8inx 3184 45 groups group NNS cord-010092-uftc8inx 3184 46 ( ( -LRB- cord-010092-uftc8inx 3184 47 median median NN cord-010092-uftc8inx 3184 48 ; ; : cord-010092-uftc8inx 3184 49 range range NN cord-010092-uftc8inx 3184 50 in in IN cord-010092-uftc8inx 3184 51 age age NN cord-010092-uftc8inx 3184 52 groups group NNS cord-010092-uftc8inx 3184 53 1 1 CD cord-010092-uftc8inx 3184 54 - - SYM cord-010092-uftc8inx 3184 55 5 5 CD cord-010092-uftc8inx 3184 56 in in IN cord-010092-uftc8inx 3184 57 females female NNS cord-010092-uftc8inx 3184 58 : : : cord-010092-uftc8inx 3184 59 40;3 40;3 CD cord-010092-uftc8inx 3184 60 - - SYM cord-010092-uftc8inx 3184 61 702 702 CD cord-010092-uftc8inx 3184 62 , , , cord-010092-uftc8inx 3184 63 52;6 52;6 CD cord-010092-uftc8inx 3184 64 - - SYM cord-010092-uftc8inx 3184 65 619 619 CD cord-010092-uftc8inx 3184 66 , , , cord-010092-uftc8inx 3184 67 60;6 60;6 CD cord-010092-uftc8inx 3184 68 - - SYM cord-010092-uftc8inx 3184 69 480 480 CD cord-010092-uftc8inx 3184 70 , , , cord-010092-uftc8inx 3184 71 60;8 60;8 CD cord-010092-uftc8inx 3184 72 - - SYM cord-010092-uftc8inx 3184 73 725 725 CD cord-010092-uftc8inx 3184 74 , , , cord-010092-uftc8inx 3184 75 98 98 CD cord-010092-uftc8inx 3184 76 ; ; : cord-010092-uftc8inx 3184 77 10 10 CD cord-010092-uftc8inx 3184 78 - - SYM cord-010092-uftc8inx 3184 79 604 604 CD cord-010092-uftc8inx 3184 80 and and CC cord-010092-uftc8inx 3184 81 in in IN cord-010092-uftc8inx 3184 82 males male NNS cord-010092-uftc8inx 3184 83 : : : cord-010092-uftc8inx 3184 84 99;8 99;8 CD cord-010092-uftc8inx 3184 85 - - SYM cord-010092-uftc8inx 3184 86 661 661 CD cord-010092-uftc8inx 3184 87 , , , cord-010092-uftc8inx 3185 1 161;18 161;18 NNP cord-010092-uftc8inx 3185 2 - - HYPH cord-010092-uftc8inx 3185 3 1080 1080 CD cord-010092-uftc8inx 3185 4 , , , cord-010092-uftc8inx 3185 5 206;15 206;15 NNS cord-010092-uftc8inx 3185 6 - - HYPH cord-010092-uftc8inx 3185 7 1090 1090 CD cord-010092-uftc8inx 3185 8 , , , cord-010092-uftc8inx 3185 9 220;26 220;26 NNP cord-010092-uftc8inx 3185 10 - - HYPH cord-010092-uftc8inx 3185 11 1430 1430 CD cord-010092-uftc8inx 3185 12 , , , cord-010092-uftc8inx 3185 13 221;33 221;33 CD cord-010092-uftc8inx 3185 14 - - SYM cord-010092-uftc8inx 3185 15 981 981 CD cord-010092-uftc8inx 3185 16 respectively respectively RB cord-010092-uftc8inx 3185 17 ) ) -RRB- cord-010092-uftc8inx 3185 18 . . . cord-010092-uftc8inx 3186 1 Percentage percentage NN cord-010092-uftc8inx 3186 2 of of IN cord-010092-uftc8inx 3186 3 females female NNS cord-010092-uftc8inx 3186 4 with with IN cord-010092-uftc8inx 3186 5 ferritin ferritin NN cord-010092-uftc8inx 3186 6 ≤ ≤ NNP cord-010092-uftc8inx 3186 7 15 15 CD cord-010092-uftc8inx 3187 1 lg lg NNP cord-010092-uftc8inx 3187 2 / / SYM cord-010092-uftc8inx 3187 3 l l NNP cord-010092-uftc8inx 3187 4 were be VBD cord-010092-uftc8inx 3187 5 8.6 8.6 CD cord-010092-uftc8inx 3187 6 % % NN cord-010092-uftc8inx 3187 7 , , , cord-010092-uftc8inx 3187 8 3.8 3.8 CD cord-010092-uftc8inx 3187 9 % % NN cord-010092-uftc8inx 3187 10 , , , cord-010092-uftc8inx 3187 11 3.7 3.7 CD cord-010092-uftc8inx 3187 12 % % NN cord-010092-uftc8inx 3187 13 , , , cord-010092-uftc8inx 3187 14 6.7 6.7 CD cord-010092-uftc8inx 3187 15 % % NN cord-010092-uftc8inx 3187 16 and and CC cord-010092-uftc8inx 3187 17 2.0 2.0 CD cord-010092-uftc8inx 3187 18 % % NN cord-010092-uftc8inx 3187 19 , , , cord-010092-uftc8inx 3187 20 while while IN cord-010092-uftc8inx 3187 21 percentage percentage NN cord-010092-uftc8inx 3187 22 of of IN cord-010092-uftc8inx 3187 23 males male NNS cord-010092-uftc8inx 3187 24 with with IN cord-010092-uftc8inx 3187 25 ferritin ferritin NN cord-010092-uftc8inx 3187 26 ≤ ≤ NNP cord-010092-uftc8inx 3187 27 15 15 CD cord-010092-uftc8inx 3188 1 lg lg NNP cord-010092-uftc8inx 3188 2 / / SYM cord-010092-uftc8inx 3188 3 l l NNP cord-010092-uftc8inx 3188 4 were be VBD cord-010092-uftc8inx 3188 5 0.2 0.2 CD cord-010092-uftc8inx 3188 6 % % NN cord-010092-uftc8inx 3188 7 , , , cord-010092-uftc8inx 3188 8 0.0 0.0 CD cord-010092-uftc8inx 3188 9 % % NN cord-010092-uftc8inx 3188 10 , , , cord-010092-uftc8inx 3188 11 0.1 0.1 CD cord-010092-uftc8inx 3188 12 % % NN cord-010092-uftc8inx 3188 13 , , , cord-010092-uftc8inx 3188 14 0.0 0.0 CD cord-010092-uftc8inx 3188 15 % % NN cord-010092-uftc8inx 3188 16 and and CC cord-010092-uftc8inx 3188 17 0.0 0.0 CD cord-010092-uftc8inx 3188 18 % % NN cord-010092-uftc8inx 3188 19 for for IN cord-010092-uftc8inx 3188 20 the the DT cord-010092-uftc8inx 3188 21 age age NN cord-010092-uftc8inx 3188 22 groups group NNS cord-010092-uftc8inx 3188 23 1 1 CD cord-010092-uftc8inx 3188 24 - - SYM cord-010092-uftc8inx 3188 25 5 5 CD cord-010092-uftc8inx 3188 26 respectively respectively RB cord-010092-uftc8inx 3188 27 . . . cord-010092-uftc8inx 3189 1 White white JJ cord-010092-uftc8inx 3189 2 blood blood NN cord-010092-uftc8inx 3189 3 cell cell NN cord-010092-uftc8inx 3189 4 counts count NNS cord-010092-uftc8inx 3189 5 ( ( -LRB- cord-010092-uftc8inx 3189 6 WBC WBC NNP cord-010092-uftc8inx 3189 7 ) ) -RRB- cord-010092-uftc8inx 3189 8 were be VBD cord-010092-uftc8inx 3189 9 slightly slightly RB cord-010092-uftc8inx 3189 10 higher high JJR cord-010092-uftc8inx 3189 11 in in IN cord-010092-uftc8inx 3189 12 females female NNS cord-010092-uftc8inx 3189 13 compared compare VBN cord-010092-uftc8inx 3189 14 to to IN cord-010092-uftc8inx 3189 15 males male NNS cord-010092-uftc8inx 3189 16 ( ( -LRB- cord-010092-uftc8inx 3189 17 meanAESEM meanAESEM NNP cord-010092-uftc8inx 3189 18 : : : cord-010092-uftc8inx 3189 19 7.2 7.2 CD cord-010092-uftc8inx 3189 20 AE AE NNP cord-010092-uftc8inx 3189 21 0.02 0.02 CD cord-010092-uftc8inx 3189 22 vs vs IN cord-010092-uftc8inx 3189 23 6.6 6.6 CD cord-010092-uftc8inx 3189 24 AE AE NNP cord-010092-uftc8inx 3189 25 0.03 0.03 CD cord-010092-uftc8inx 3189 26 ; ; : cord-010092-uftc8inx 3189 27 P p NN cord-010092-uftc8inx 3189 28 < < XX cord-010092-uftc8inx 3189 29 0.000 0.000 CD cord-010092-uftc8inx 3189 30 ) ) -RRB- cord-010092-uftc8inx 3189 31 . . . cord-010092-uftc8inx 3190 1 Percentage percentage NN cord-010092-uftc8inx 3190 2 of of IN cord-010092-uftc8inx 3190 3 females female NNS cord-010092-uftc8inx 3190 4 with with IN cord-010092-uftc8inx 3190 5 WBC WBC NNP cord-010092-uftc8inx 3190 6 > > XX cord-010092-uftc8inx 3191 1 12x10 12x10 CD cord-010092-uftc8inx 3191 2 9 9 CD cord-010092-uftc8inx 3191 3 /L /L , cord-010092-uftc8inx 3191 4 were be VBD cord-010092-uftc8inx 3191 5 1.8 1.8 CD cord-010092-uftc8inx 3191 6 % % NN cord-010092-uftc8inx 3191 7 , , , cord-010092-uftc8inx 3191 8 1.3 1.3 CD cord-010092-uftc8inx 3191 9 % % NN cord-010092-uftc8inx 3191 10 , , , cord-010092-uftc8inx 3191 11 1.7 1.7 CD cord-010092-uftc8inx 3191 12 % % NN cord-010092-uftc8inx 3191 13 , , , cord-010092-uftc8inx 3191 14 1.4 1.4 CD cord-010092-uftc8inx 3191 15 % % NN cord-010092-uftc8inx 3191 16 and and CC cord-010092-uftc8inx 3191 17 0.3 0.3 CD cord-010092-uftc8inx 3191 18 % % NN cord-010092-uftc8inx 3191 19 , , , cord-010092-uftc8inx 3191 20 while while IN cord-010092-uftc8inx 3191 21 percentage percentage NN cord-010092-uftc8inx 3191 22 of of IN cord-010092-uftc8inx 3191 23 males male NNS cord-010092-uftc8inx 3191 24 with with IN cord-010092-uftc8inx 3191 25 WBC WBC NNP cord-010092-uftc8inx 3191 26 > > XX cord-010092-uftc8inx 3191 27 12x10 12x10 CD cord-010092-uftc8inx 3191 28 9 9 CD cord-010092-uftc8inx 3191 29 /L /L , cord-010092-uftc8inx 3191 30 were be VBD cord-010092-uftc8inx 3191 31 1.4 1.4 CD cord-010092-uftc8inx 3191 32 % % NN cord-010092-uftc8inx 3191 33 , , , cord-010092-uftc8inx 3191 34 0.9 0.9 CD cord-010092-uftc8inx 3191 35 % % NN cord-010092-uftc8inx 3191 36 , , , cord-010092-uftc8inx 3191 37 0.5 0.5 CD cord-010092-uftc8inx 3191 38 % % NN cord-010092-uftc8inx 3191 39 , , , cord-010092-uftc8inx 3191 40 1.2 1.2 CD cord-010092-uftc8inx 3191 41 % % NN cord-010092-uftc8inx 3191 42 and and CC cord-010092-uftc8inx 3191 43 0.9 0.9 CD cord-010092-uftc8inx 3191 44 % % NN cord-010092-uftc8inx 3191 45 for for IN cord-010092-uftc8inx 3191 46 the the DT cord-010092-uftc8inx 3191 47 age age NN cord-010092-uftc8inx 3191 48 groups group NNS cord-010092-uftc8inx 3191 49 1 1 CD cord-010092-uftc8inx 3191 50 - - SYM cord-010092-uftc8inx 3191 51 5 5 CD cord-010092-uftc8inx 3191 52 respectively respectively RB cord-010092-uftc8inx 3191 53 . . . cord-010092-uftc8inx 3192 1 None none NN cord-010092-uftc8inx 3192 2 had have VBD cord-010092-uftc8inx 3192 3 WBC WBC NNP cord-010092-uftc8inx 3192 4 < < NNP cord-010092-uftc8inx 3192 5 2x10 2x10 CD cord-010092-uftc8inx 3192 6 9 9 CD cord-010092-uftc8inx 3193 1 /L. /L. . cord-010092-uftc8inx 3194 1 Platelet platelet NN cord-010092-uftc8inx 3194 2 counts count NNS cord-010092-uftc8inx 3194 3 ( ( -LRB- cord-010092-uftc8inx 3194 4 PLT PLT NNP cord-010092-uftc8inx 3194 5 ) ) -RRB- cord-010092-uftc8inx 3194 6 were be VBD cord-010092-uftc8inx 3194 7 higher high JJR cord-010092-uftc8inx 3194 8 in in IN cord-010092-uftc8inx 3194 9 females female NNS cord-010092-uftc8inx 3194 10 compared compare VBN cord-010092-uftc8inx 3194 11 to to IN cord-010092-uftc8inx 3194 12 males male NNS cord-010092-uftc8inx 3195 1 ( ( -LRB- cord-010092-uftc8inx 3195 2 meanAESEM meanAESEM NNP cord-010092-uftc8inx 3196 1 : : : cord-010092-uftc8inx 3196 2 257 257 CD cord-010092-uftc8inx 3196 3 AE AE NNP cord-010092-uftc8inx 3196 4 0.6 0.6 CD cord-010092-uftc8inx 3196 5 vs vs IN cord-010092-uftc8inx 3196 6 222 222 CD cord-010092-uftc8inx 3196 7 AE AE NNP cord-010092-uftc8inx 3196 8 0.6 0.6 CD cord-010092-uftc8inx 3196 9 ; ; : cord-010092-uftc8inx 3196 10 P p NN cord-010092-uftc8inx 3196 11 < < XX cord-010092-uftc8inx 3196 12 0.000).Percentage 0.000).percentage NN cord-010092-uftc8inx 3196 13 of of IN cord-010092-uftc8inx 3196 14 females female NNS cord-010092-uftc8inx 3196 15 with with IN cord-010092-uftc8inx 3196 16 PLT PLT NNP cord-010092-uftc8inx 3196 17 < < XX cord-010092-uftc8inx 3196 18 150x10 150x10 CD cord-010092-uftc8inx 3196 19 9 9 CD cord-010092-uftc8inx 3196 20 /L /L , cord-010092-uftc8inx 3196 21 were be VBD cord-010092-uftc8inx 3196 22 1.0 1.0 CD cord-010092-uftc8inx 3196 23 % % NN cord-010092-uftc8inx 3196 24 , , , cord-010092-uftc8inx 3196 25 1.5 1.5 CD cord-010092-uftc8inx 3196 26 % % NN cord-010092-uftc8inx 3196 27 , , , cord-010092-uftc8inx 3196 28 2.2 2.2 CD cord-010092-uftc8inx 3196 29 % % NN cord-010092-uftc8inx 3196 30 , , , cord-010092-uftc8inx 3196 31 2.4 2.4 CD cord-010092-uftc8inx 3196 32 % % NN cord-010092-uftc8inx 3196 33 and and CC cord-010092-uftc8inx 3196 34 1.0 1.0 CD cord-010092-uftc8inx 3196 35 % % NN cord-010092-uftc8inx 3196 36 , , , cord-010092-uftc8inx 3196 37 while while IN cord-010092-uftc8inx 3196 38 percentage percentage NN cord-010092-uftc8inx 3196 39 of of IN cord-010092-uftc8inx 3196 40 males male NNS cord-010092-uftc8inx 3196 41 with with IN cord-010092-uftc8inx 3196 42 PLT PLT NNP cord-010092-uftc8inx 3196 43 < < XX cord-010092-uftc8inx 3196 44 150x10 150x10 CD cord-010092-uftc8inx 3196 45 9 9 CD cord-010092-uftc8inx 3196 46 /L /L , cord-010092-uftc8inx 3196 47 were be VBD cord-010092-uftc8inx 3196 48 2.6 2.6 CD cord-010092-uftc8inx 3196 49 % % NN cord-010092-uftc8inx 3196 50 , , , cord-010092-uftc8inx 3196 51 3.6 3.6 CD cord-010092-uftc8inx 3196 52 % % NN cord-010092-uftc8inx 3196 53 , , , cord-010092-uftc8inx 3196 54 2.7 2.7 CD cord-010092-uftc8inx 3196 55 % % NN cord-010092-uftc8inx 3196 56 , , , cord-010092-uftc8inx 3196 57 2.4 2.4 CD cord-010092-uftc8inx 3196 58 % % NN cord-010092-uftc8inx 3196 59 and and CC cord-010092-uftc8inx 3196 60 1.6 1.6 CD cord-010092-uftc8inx 3196 61 % % NN cord-010092-uftc8inx 3196 62 for for IN cord-010092-uftc8inx 3196 63 the the DT cord-010092-uftc8inx 3196 64 age age NN cord-010092-uftc8inx 3196 65 groups group NNS cord-010092-uftc8inx 3196 66 1 1 CD cord-010092-uftc8inx 3196 67 - - SYM cord-010092-uftc8inx 3196 68 5 5 CD cord-010092-uftc8inx 3196 69 respectively respectively RB cord-010092-uftc8inx 3196 70 . . . cord-010092-uftc8inx 3197 1 Among among IN cord-010092-uftc8inx 3197 2 the the DT cord-010092-uftc8inx 3197 3 low low JJ cord-010092-uftc8inx 3197 4 PLT PLT NNP cord-010092-uftc8inx 3197 5 counts count VBZ cord-010092-uftc8inx 3197 6 most most RBS cord-010092-uftc8inx 3197 7 were be VBD cord-010092-uftc8inx 3197 8 caused cause VBN cord-010092-uftc8inx 3197 9 by by IN cord-010092-uftc8inx 3197 10 EDTA edta NN cord-010092-uftc8inx 3197 11 - - HYPH cord-010092-uftc8inx 3197 12 dependent dependent JJ cord-010092-uftc8inx 3197 13 Pseudothrombocytopenia Pseudothrombocytopenia NNP cord-010092-uftc8inx 3197 14 . . . cord-010092-uftc8inx 3198 1 Extreme extreme JJ cord-010092-uftc8inx 3198 2 deviations deviation NNS cord-010092-uftc8inx 3198 3 from from IN cord-010092-uftc8inx 3198 4 normality normality NN cord-010092-uftc8inx 3198 5 were be VBD cord-010092-uftc8inx 3198 6 seldom seldom RB cord-010092-uftc8inx 3198 7 and and CC cord-010092-uftc8inx 3198 8 referred refer VBN cord-010092-uftc8inx 3198 9 to to IN cord-010092-uftc8inx 3198 10 GPs GPs NNP cord-010092-uftc8inx 3198 11 for for IN cord-010092-uftc8inx 3198 12 further further JJ cord-010092-uftc8inx 3198 13 investigations investigation NNS cord-010092-uftc8inx 3198 14 . . . cord-010092-uftc8inx 3199 1 Summary Summary NNP cord-010092-uftc8inx 3199 2 / / SYM cord-010092-uftc8inx 3199 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 3199 4 : : : cord-010092-uftc8inx 3200 1 First first JJ cord-010092-uftc8inx 3200 2 time time NN cord-010092-uftc8inx 3200 3 donors donor NNS cord-010092-uftc8inx 3200 4 are be VBP cord-010092-uftc8inx 3200 5 young young JJ cord-010092-uftc8inx 3200 6 with with IN cord-010092-uftc8inx 3200 7 75 75 CD cord-010092-uftc8inx 3200 8 % % NN cord-010092-uftc8inx 3200 9 younger young JJR cord-010092-uftc8inx 3200 10 than than IN cord-010092-uftc8inx 3200 11 30 30 CD cord-010092-uftc8inx 3200 12 years year NNS cord-010092-uftc8inx 3200 13 of of IN cord-010092-uftc8inx 3200 14 age age NN cord-010092-uftc8inx 3200 15 and and CC cord-010092-uftc8inx 3200 16 the the DT cord-010092-uftc8inx 3200 17 female female JJ cord-010092-uftc8inx 3200 18 / / SYM cord-010092-uftc8inx 3200 19 male male JJ cord-010092-uftc8inx 3200 20 ratio ratio NN cord-010092-uftc8inx 3200 21 was be VBD cord-010092-uftc8inx 3200 22 58/42 58/42 CD cord-010092-uftc8inx 3200 23 . . . cord-010092-uftc8inx 3201 1 Of of IN cord-010092-uftc8inx 3201 2 the the DT cord-010092-uftc8inx 3201 3 16 16 CD cord-010092-uftc8inx 3201 4 583 583 CD cord-010092-uftc8inx 3201 5 first first JJ cord-010092-uftc8inx 3201 6 time time NN cord-010092-uftc8inx 3201 7 donors donor NNS cord-010092-uftc8inx 3201 8 with with IN cord-010092-uftc8inx 3201 9 data datum NNS cord-010092-uftc8inx 3201 10 on on IN cord-010092-uftc8inx 3201 11 ferritin ferritin NN cord-010092-uftc8inx 3201 12 available available JJ cord-010092-uftc8inx 3201 13 , , , cord-010092-uftc8inx 3201 14 14 14 CD cord-010092-uftc8inx 3201 15 % % NN cord-010092-uftc8inx 3201 16 had have VBD cord-010092-uftc8inx 3201 17 low low JJ cord-010092-uftc8inx 3201 18 ferritin ferritin NNS cord-010092-uftc8inx 3201 19 ( ( -LRB- cord-010092-uftc8inx 3201 20 ≤ ≤ NNP cord-010092-uftc8inx 3201 21 30 30 CD cord-010092-uftc8inx 3201 22 lg lg NNP cord-010092-uftc8inx 3201 23 / / SYM cord-010092-uftc8inx 3201 24 l l NN cord-010092-uftc8inx 3201 25 ) ) -RRB- cord-010092-uftc8inx 3201 26 . . . cord-010092-uftc8inx 3202 1 The the DT cord-010092-uftc8inx 3202 2 typical typical JJ cord-010092-uftc8inx 3202 3 male male JJ cord-010092-uftc8inx 3202 4 first first JJ cord-010092-uftc8inx 3202 5 time time NN cord-010092-uftc8inx 3202 6 donors donor NNS cord-010092-uftc8inx 3202 7 neither neither CC cord-010092-uftc8inx 3202 8 had have VBD cord-010092-uftc8inx 3202 9 low low JJ cord-010092-uftc8inx 3202 10 Hb Hb NNP cord-010092-uftc8inx 3202 11 nor nor CC cord-010092-uftc8inx 3202 12 low low JJ cord-010092-uftc8inx 3202 13 ferritin ferritin NN cord-010092-uftc8inx 3202 14 , , , cord-010092-uftc8inx 3202 15 even even RB cord-010092-uftc8inx 3202 16 with with IN cord-010092-uftc8inx 3202 17 a a DT cord-010092-uftc8inx 3202 18 significantly significantly RB cord-010092-uftc8inx 3202 19 lower low JJR cord-010092-uftc8inx 3202 20 ferritin ferritin NN cord-010092-uftc8inx 3202 21 in in IN cord-010092-uftc8inx 3202 22 younger young JJR cord-010092-uftc8inx 3202 23 donors donor NNS cord-010092-uftc8inx 3202 24 . . . cord-010092-uftc8inx 3203 1 In in IN cord-010092-uftc8inx 3203 2 female female JJ cord-010092-uftc8inx 3203 3 first first JJ cord-010092-uftc8inx 3203 4 time time NN cord-010092-uftc8inx 3203 5 donors donor NNS cord-010092-uftc8inx 3203 6 the the DT cord-010092-uftc8inx 3203 7 prevalence prevalence NN cord-010092-uftc8inx 3203 8 of of IN cord-010092-uftc8inx 3203 9 low low JJ cord-010092-uftc8inx 3203 10 Hb Hb NNP cord-010092-uftc8inx 3203 11 ( ( -LRB- cord-010092-uftc8inx 3203 12 6%<12.5 6%<12.5 NNP cord-010092-uftc8inx 3203 13 g g NNP cord-010092-uftc8inx 3203 14 / / SYM cord-010092-uftc8inx 3203 15 dl dl NN cord-010092-uftc8inx 3203 16 ) ) -RRB- cord-010092-uftc8inx 3203 17 and and CC cord-010092-uftc8inx 3203 18 low low JJ cord-010092-uftc8inx 3203 19 iron iron NN cord-010092-uftc8inx 3203 20 stores store NNS cord-010092-uftc8inx 3203 21 ( ( -LRB- cord-010092-uftc8inx 3203 22 23%≤30 23%≤30 CD cord-010092-uftc8inx 3203 23 lg lg NNP cord-010092-uftc8inx 3203 24 / / SYM cord-010092-uftc8inx 3203 25 l l NNP cord-010092-uftc8inx 3203 26 ) ) -RRB- cord-010092-uftc8inx 3203 27 is be VBZ cord-010092-uftc8inx 3203 28 high high JJ cord-010092-uftc8inx 3203 29 . . . cord-010092-uftc8inx 3204 1 In in IN cord-010092-uftc8inx 3204 2 all all DT cord-010092-uftc8inx 3204 3 , , , cord-010092-uftc8inx 3204 4 while while IN cord-010092-uftc8inx 3204 5 all all DT cord-010092-uftc8inx 3204 6 first first JJ cord-010092-uftc8inx 3204 7 time time NN cord-010092-uftc8inx 3204 8 donors donor NNS cord-010092-uftc8inx 3204 9 are be VBP cord-010092-uftc8inx 3204 10 highly highly RB cord-010092-uftc8inx 3204 11 appreciated appreciate VBN cord-010092-uftc8inx 3204 12 , , , cord-010092-uftc8inx 3204 13 campaigns campaign NNS cord-010092-uftc8inx 3204 14 could could MD cord-010092-uftc8inx 3204 15 target target VB cord-010092-uftc8inx 3204 16 the the DT cord-010092-uftc8inx 3204 17 male male JJ cord-010092-uftc8inx 3204 18 population population NN cord-010092-uftc8inx 3204 19 to to TO cord-010092-uftc8inx 3204 20 even even RB cord-010092-uftc8inx 3204 21 out out RP cord-010092-uftc8inx 3204 22 the the DT cord-010092-uftc8inx 3204 23 gender gender NN cord-010092-uftc8inx 3204 24 imbalance imbalance NN cord-010092-uftc8inx 3204 25 . . . cord-010092-uftc8inx 3205 1 Blood blood NN cord-010092-uftc8inx 3205 2 Centers Centers NNPS cord-010092-uftc8inx 3205 3 must must MD cord-010092-uftc8inx 3205 4 be be VB cord-010092-uftc8inx 3205 5 aware aware JJ cord-010092-uftc8inx 3205 6 of of IN cord-010092-uftc8inx 3205 7 the the DT cord-010092-uftc8inx 3205 8 higher high JJR cord-010092-uftc8inx 3205 9 prevalence prevalence NN cord-010092-uftc8inx 3205 10 of of IN cord-010092-uftc8inx 3205 11 low low JJ cord-010092-uftc8inx 3205 12 iron iron NN cord-010092-uftc8inx 3205 13 stores store NNS cord-010092-uftc8inx 3205 14 in in IN cord-010092-uftc8inx 3205 15 the the DT cord-010092-uftc8inx 3205 16 youngest young JJS cord-010092-uftc8inx 3205 17 donors donor NNS cord-010092-uftc8inx 3205 18 . . . cord-010092-uftc8inx 3206 1 Background background NN cord-010092-uftc8inx 3206 2 : : : cord-010092-uftc8inx 3207 1 The the DT cord-010092-uftc8inx 3207 2 aim aim NN cord-010092-uftc8inx 3207 3 of of IN cord-010092-uftc8inx 3207 4 assessing assess VBG cord-010092-uftc8inx 3207 5 suitability suitability NN cord-010092-uftc8inx 3207 6 of of IN cord-010092-uftc8inx 3207 7 prospective prospective JJ cord-010092-uftc8inx 3207 8 blood blood NN cord-010092-uftc8inx 3207 9 donors donor NNS cord-010092-uftc8inx 3207 10 is be VBZ cord-010092-uftc8inx 3207 11 protection protection NN cord-010092-uftc8inx 3207 12 of of IN cord-010092-uftc8inx 3207 13 their -PRON- PRP$ cord-010092-uftc8inx 3207 14 health health NN cord-010092-uftc8inx 3207 15 and and CC cord-010092-uftc8inx 3207 16 the the DT cord-010092-uftc8inx 3207 17 safety safety NN cord-010092-uftc8inx 3207 18 of of IN cord-010092-uftc8inx 3207 19 transfused transfuse VBN cord-010092-uftc8inx 3207 20 patients patient NNS cord-010092-uftc8inx 3207 21 . . . cord-010092-uftc8inx 3208 1 Selection selection NN cord-010092-uftc8inx 3208 2 process process NN cord-010092-uftc8inx 3208 3 is be VBZ cord-010092-uftc8inx 3208 4 not not RB cord-010092-uftc8inx 3208 5 always always RB cord-010092-uftc8inx 3208 6 effective effective JJ cord-010092-uftc8inx 3208 7 in in IN cord-010092-uftc8inx 3208 8 obtaining obtain VBG cord-010092-uftc8inx 3208 9 all all DT cord-010092-uftc8inx 3208 10 relevant relevant JJ cord-010092-uftc8inx 3208 11 information information NN cord-010092-uftc8inx 3208 12 from from IN cord-010092-uftc8inx 3208 13 blood blood NN cord-010092-uftc8inx 3208 14 donors donor NNS cord-010092-uftc8inx 3208 15 in in IN cord-010092-uftc8inx 3208 16 a a DT cord-010092-uftc8inx 3208 17 timely timely JJ cord-010092-uftc8inx 3208 18 manner manner NN cord-010092-uftc8inx 3208 19 . . . cord-010092-uftc8inx 3209 1 For for IN cord-010092-uftc8inx 3209 2 several several JJ cord-010092-uftc8inx 3209 3 reasons reason NNS cord-010092-uftc8inx 3209 4 , , , cord-010092-uftc8inx 3209 5 some some DT cord-010092-uftc8inx 3209 6 risks risk NNS cord-010092-uftc8inx 3209 7 remain remain VBP cord-010092-uftc8inx 3209 8 undetected undetected JJ cord-010092-uftc8inx 3209 9 or or CC cord-010092-uftc8inx 3209 10 they -PRON- PRP cord-010092-uftc8inx 3209 11 are be VBP cord-010092-uftc8inx 3209 12 disclosed disclose VBN cord-010092-uftc8inx 3209 13 at at IN cord-010092-uftc8inx 3209 14 a a DT cord-010092-uftc8inx 3209 15 future future JJ cord-010092-uftc8inx 3209 16 donation(s donation(s NNP cord-010092-uftc8inx 3209 17 ) ) -RRB- cord-010092-uftc8inx 3209 18 . . . cord-010092-uftc8inx 3210 1 Therefore therefore RB cord-010092-uftc8inx 3210 2 , , , cord-010092-uftc8inx 3210 3 recording recording NN cord-010092-uftc8inx 3210 4 and and CC cord-010092-uftc8inx 3210 5 management management NN cord-010092-uftc8inx 3210 6 of of IN cord-010092-uftc8inx 3210 7 post post JJ cord-010092-uftc8inx 3210 8 - - JJ cord-010092-uftc8inx 3210 9 donation donation JJ cord-010092-uftc8inx 3210 10 information information NN cord-010092-uftc8inx 3210 11 ( ( -LRB- cord-010092-uftc8inx 3210 12 PDI PDI NNP cord-010092-uftc8inx 3210 13 ) ) -RRB- cord-010092-uftc8inx 3210 14 are be VBP cord-010092-uftc8inx 3210 15 of of IN cord-010092-uftc8inx 3210 16 great great JJ cord-010092-uftc8inx 3210 17 importance importance NN cord-010092-uftc8inx 3210 18 for for IN cord-010092-uftc8inx 3210 19 improvement improvement NN cord-010092-uftc8inx 3210 20 of of IN cord-010092-uftc8inx 3210 21 transfusion transfusion NN cord-010092-uftc8inx 3210 22 safety safety NN cord-010092-uftc8inx 3210 23 , , , cord-010092-uftc8inx 3210 24 donor donor NN cord-010092-uftc8inx 3210 25 counselling counselling NN cord-010092-uftc8inx 3210 26 and and CC cord-010092-uftc8inx 3210 27 education education NN cord-010092-uftc8inx 3210 28 as as RB cord-010092-uftc8inx 3210 29 well well RB cord-010092-uftc8inx 3210 30 as as IN cord-010092-uftc8inx 3210 31 overall overall JJ cord-010092-uftc8inx 3210 32 improvement improvement NN cord-010092-uftc8inx 3210 33 of of IN cord-010092-uftc8inx 3210 34 the the DT cord-010092-uftc8inx 3210 35 selection selection NN cord-010092-uftc8inx 3210 36 process process NN cord-010092-uftc8inx 3210 37 . . . cord-010092-uftc8inx 3211 1 Aims aim VBZ cord-010092-uftc8inx 3211 2 : : : cord-010092-uftc8inx 3212 1 The the DT cord-010092-uftc8inx 3212 2 aim aim NN cord-010092-uftc8inx 3212 3 of of IN cord-010092-uftc8inx 3212 4 the the DT cord-010092-uftc8inx 3212 5 study study NN cord-010092-uftc8inx 3212 6 was be VBD cord-010092-uftc8inx 3212 7 to to TO cord-010092-uftc8inx 3212 8 present present VB cord-010092-uftc8inx 3212 9 results result NNS cord-010092-uftc8inx 3212 10 of of IN cord-010092-uftc8inx 3212 11 PDI PDI NNP cord-010092-uftc8inx 3212 12 management management NN cord-010092-uftc8inx 3212 13 at at IN cord-010092-uftc8inx 3212 14 Croatian Croatian NNP cord-010092-uftc8inx 3212 15 Institute Institute NNP cord-010092-uftc8inx 3212 16 of of IN cord-010092-uftc8inx 3212 17 Transfusion Transfusion NNP cord-010092-uftc8inx 3212 18 Medicine Medicine NNP cord-010092-uftc8inx 3212 19 ( ( -LRB- cord-010092-uftc8inx 3212 20 CITM CITM NNP cord-010092-uftc8inx 3212 21 ) ) -RRB- cord-010092-uftc8inx 3212 22 and and CC cord-010092-uftc8inx 3212 23 the the DT cord-010092-uftc8inx 3212 24 effect effect NN cord-010092-uftc8inx 3212 25 of of IN cord-010092-uftc8inx 3212 26 education education NN cord-010092-uftc8inx 3212 27 activities activity NNS cord-010092-uftc8inx 3212 28 on on IN cord-010092-uftc8inx 3212 29 their -PRON- PRP$ cord-010092-uftc8inx 3212 30 trends trend NNS cord-010092-uftc8inx 3212 31 . . . cord-010092-uftc8inx 3213 1 Methods method NNS cord-010092-uftc8inx 3213 2 : : : cord-010092-uftc8inx 3213 3 We -PRON- PRP cord-010092-uftc8inx 3213 4 have have VBP cord-010092-uftc8inx 3213 5 analyzed analyze VBN cord-010092-uftc8inx 3213 6 reports report NNS cord-010092-uftc8inx 3213 7 on on IN cord-010092-uftc8inx 3213 8 PDI PDI NNP cord-010092-uftc8inx 3213 9 recorded record VBD cord-010092-uftc8inx 3213 10 in in IN cord-010092-uftc8inx 3213 11 two two CD cord-010092-uftc8inx 3213 12 - - HYPH cord-010092-uftc8inx 3213 13 year year NN cord-010092-uftc8inx 3213 14 period period NN cord-010092-uftc8inx 3213 15 ( ( -LRB- cord-010092-uftc8inx 3213 16 2017 2017 CD cord-010092-uftc8inx 3213 17 - - SYM cord-010092-uftc8inx 3213 18 2018 2018 CD cord-010092-uftc8inx 3213 19 ) ) -RRB- cord-010092-uftc8inx 3213 20 , , , cord-010092-uftc8inx 3213 21 according accord VBG cord-010092-uftc8inx 3213 22 to to IN cord-010092-uftc8inx 3213 23 the the DT cord-010092-uftc8inx 3213 24 types type NNS cord-010092-uftc8inx 3213 25 of of IN cord-010092-uftc8inx 3213 26 information information NN cord-010092-uftc8inx 3213 27 obtained obtain VBN cord-010092-uftc8inx 3213 28 , , , cord-010092-uftc8inx 3213 29 age age NN cord-010092-uftc8inx 3213 30 and and CC cord-010092-uftc8inx 3213 31 sex sex NN cord-010092-uftc8inx 3213 32 of of IN cord-010092-uftc8inx 3213 33 blood blood NN cord-010092-uftc8inx 3213 34 donors donor NNS cord-010092-uftc8inx 3213 35 , , , cord-010092-uftc8inx 3213 36 total total JJ cord-010092-uftc8inx 3213 37 number number NN cord-010092-uftc8inx 3213 38 of of IN cord-010092-uftc8inx 3213 39 their -PRON- PRP$ cord-010092-uftc8inx 3213 40 donations donation NNS cord-010092-uftc8inx 3213 41 preceding precede VBG cord-010092-uftc8inx 3213 42 PDI PDI NNP cord-010092-uftc8inx 3213 43 , , , cord-010092-uftc8inx 3213 44 and and CC cord-010092-uftc8inx 3213 45 the the DT cord-010092-uftc8inx 3213 46 time time NN cord-010092-uftc8inx 3213 47 of of IN cord-010092-uftc8inx 3213 48 receiving receive VBG cord-010092-uftc8inx 3213 49 the the DT cord-010092-uftc8inx 3213 50 information information NN cord-010092-uftc8inx 3213 51 . . . cord-010092-uftc8inx 3214 1 The the DT cord-010092-uftc8inx 3214 2 effect effect NN cord-010092-uftc8inx 3214 3 of of IN cord-010092-uftc8inx 3214 4 an an DT cord-010092-uftc8inx 3214 5 information information NN cord-010092-uftc8inx 3214 6 leaflet leaflet NN cord-010092-uftc8inx 3214 7 on on IN cord-010092-uftc8inx 3214 8 PDI PDI NNP cord-010092-uftc8inx 3214 9 launched launch VBD cord-010092-uftc8inx 3214 10 in in IN cord-010092-uftc8inx 3214 11 November November NNP cord-010092-uftc8inx 3214 12 2017 2017 CD cord-010092-uftc8inx 3214 13 was be VBD cord-010092-uftc8inx 3214 14 assessed assess VBN cord-010092-uftc8inx 3214 15 by by IN cord-010092-uftc8inx 3214 16 comparing compare VBG cord-010092-uftc8inx 3214 17 results result NNS cord-010092-uftc8inx 3214 18 in in IN cord-010092-uftc8inx 3214 19 two two CD cord-010092-uftc8inx 3214 20 study study NN cord-010092-uftc8inx 3214 21 years year NNS cord-010092-uftc8inx 3214 22 . . . cord-010092-uftc8inx 3215 1 Results result NNS cord-010092-uftc8inx 3215 2 : : : cord-010092-uftc8inx 3216 1 A a DT cord-010092-uftc8inx 3216 2 total total NN cord-010092-uftc8inx 3216 3 of of IN cord-010092-uftc8inx 3216 4 491 491 CD cord-010092-uftc8inx 3216 5 PDI PDI NNP cord-010092-uftc8inx 3216 6 were be VBD cord-010092-uftc8inx 3216 7 recorded record VBN cord-010092-uftc8inx 3216 8 : : : cord-010092-uftc8inx 3216 9 266 266 CD cord-010092-uftc8inx 3216 10 in in IN cord-010092-uftc8inx 3216 11 2017 2017 CD cord-010092-uftc8inx 3216 12 ( ( -LRB- cord-010092-uftc8inx 3216 13 1/396 1/396 CD cord-010092-uftc8inx 3216 14 donations donation NNS cord-010092-uftc8inx 3216 15 ) ) -RRB- cord-010092-uftc8inx 3216 16 and and CC cord-010092-uftc8inx 3216 17 225 225 CD cord-010092-uftc8inx 3216 18 in in IN cord-010092-uftc8inx 3216 19 2018 2018 CD cord-010092-uftc8inx 3216 20 ( ( -LRB- cord-010092-uftc8inx 3216 21 1/452 1/452 CD cord-010092-uftc8inx 3216 22 donations donation NNS cord-010092-uftc8inx 3216 23 ) ) -RRB- cord-010092-uftc8inx 3216 24 with with IN cord-010092-uftc8inx 3216 25 the the DT cord-010092-uftc8inx 3216 26 following following JJ cord-010092-uftc8inx 3216 27 distribution distribution NN cord-010092-uftc8inx 3216 28 : : : cord-010092-uftc8inx 3216 29 nonsexual nonsexual JJ cord-010092-uftc8inx 3216 30 risk risk NN cord-010092-uftc8inx 3216 31 as as IN cord-010092-uftc8inx 3216 32 tattoo tattoo NN cord-010092-uftc8inx 3216 33 and and CC cord-010092-uftc8inx 3216 34 piercing piercing NN cord-010092-uftc8inx 3216 35 ( ( -LRB- cord-010092-uftc8inx 3216 36 17.5 17.5 CD cord-010092-uftc8inx 3216 37 % % NN cord-010092-uftc8inx 3216 38 ) ) -RRB- cord-010092-uftc8inx 3216 39 , , , cord-010092-uftc8inx 3216 40 surgical surgical JJ cord-010092-uftc8inx 3216 41 procedures procedure NNS cord-010092-uftc8inx 3216 42 ( ( -LRB- cord-010092-uftc8inx 3216 43 17.1 17.1 CD cord-010092-uftc8inx 3216 44 % % NN cord-010092-uftc8inx 3216 45 ) ) -RRB- cord-010092-uftc8inx 3216 46 , , , cord-010092-uftc8inx 3216 47 travel travel NN cord-010092-uftc8inx 3216 48 history history NN cord-010092-uftc8inx 3216 49 ( ( -LRB- cord-010092-uftc8inx 3216 50 16.1 16.1 CD cord-010092-uftc8inx 3216 51 % % NN cord-010092-uftc8inx 3216 52 ) ) -RRB- cord-010092-uftc8inx 3216 53 , , , cord-010092-uftc8inx 3216 54 infections/ infections/ CD cord-010092-uftc8inx 3216 55 contact contact NN cord-010092-uftc8inx 3216 56 ( ( -LRB- cord-010092-uftc8inx 3216 57 15.3 15.3 CD cord-010092-uftc8inx 3216 58 % % NN cord-010092-uftc8inx 3216 59 ) ) -RRB- cord-010092-uftc8inx 3216 60 , , , cord-010092-uftc8inx 3216 61 other other JJ cord-010092-uftc8inx 3216 62 medical medical JJ cord-010092-uftc8inx 3216 63 reasons reason NNS cord-010092-uftc8inx 3216 64 ( ( -LRB- cord-010092-uftc8inx 3216 65 13.4 13.4 CD cord-010092-uftc8inx 3216 66 % % NN cord-010092-uftc8inx 3216 67 ) ) -RRB- cord-010092-uftc8inx 3216 68 , , , cord-010092-uftc8inx 3216 69 endoscopy endoscopy NN cord-010092-uftc8inx 3216 70 / / , cord-010092-uftc8inx 3216 71 invasive invasive JJ cord-010092-uftc8inx 3216 72 diagnostic diagnostic JJ cord-010092-uftc8inx 3216 73 procedures procedure NNS cord-010092-uftc8inx 3216 74 ( ( -LRB- cord-010092-uftc8inx 3216 75 12.2 12.2 CD cord-010092-uftc8inx 3216 76 % % NN cord-010092-uftc8inx 3216 77 ) ) -RRB- cord-010092-uftc8inx 3216 78 , , , cord-010092-uftc8inx 3216 79 malignancy malignancy NN cord-010092-uftc8inx 3216 80 ( ( -LRB- cord-010092-uftc8inx 3216 81 4.3 4.3 CD cord-010092-uftc8inx 3216 82 % % NN cord-010092-uftc8inx 3216 83 ) ) -RRB- cord-010092-uftc8inx 3216 84 , , , cord-010092-uftc8inx 3216 85 autoimmune autoimmune JJ cord-010092-uftc8inx 3216 86 diseases disease NNS cord-010092-uftc8inx 3216 87 ( ( -LRB- cord-010092-uftc8inx 3216 88 3.7 3.7 CD cord-010092-uftc8inx 3216 89 % % NN cord-010092-uftc8inx 3216 90 ) ) -RRB- cord-010092-uftc8inx 3216 91 and and CC cord-010092-uftc8inx 3216 92 sexual sexual JJ cord-010092-uftc8inx 3216 93 risks risk NNS cord-010092-uftc8inx 3216 94 ( ( -LRB- cord-010092-uftc8inx 3216 95 0.4 0.4 CD cord-010092-uftc8inx 3216 96 % % NN cord-010092-uftc8inx 3216 97 ) ) -RRB- cord-010092-uftc8inx 3216 98 . . . cord-010092-uftc8inx 3217 1 Majority majority NN cord-010092-uftc8inx 3217 2 ( ( -LRB- cord-010092-uftc8inx 3217 3 76.4 76.4 CD cord-010092-uftc8inx 3217 4 % % NN cord-010092-uftc8inx 3217 5 ) ) -RRB- cord-010092-uftc8inx 3217 6 were be VBD cord-010092-uftc8inx 3217 7 late late JJ cord-010092-uftc8inx 3217 8 PDI PDI NNP cord-010092-uftc8inx 3217 9 , , , cord-010092-uftc8inx 3217 10 revealed reveal VBD cord-010092-uftc8inx 3217 11 on on IN cord-010092-uftc8inx 3217 12 the the DT cord-010092-uftc8inx 3217 13 future future JJ cord-010092-uftc8inx 3217 14 donation(s donation(s NNP cord-010092-uftc8inx 3217 15 ) ) -RRB- cord-010092-uftc8inx 3217 16 : : : cord-010092-uftc8inx 3218 1 58.7 58.7 CD cord-010092-uftc8inx 3218 2 % % NN cord-010092-uftc8inx 3218 3 on on IN cord-010092-uftc8inx 3218 4 the the DT cord-010092-uftc8inx 3218 5 first first JJ cord-010092-uftc8inx 3218 6 next next JJ cord-010092-uftc8inx 3218 7 donation donation NN cord-010092-uftc8inx 3218 8 , , , cord-010092-uftc8inx 3218 9 28.9 28.9 CD cord-010092-uftc8inx 3218 10 % % NN cord-010092-uftc8inx 3218 11 on on IN cord-010092-uftc8inx 3218 12 the the DT cord-010092-uftc8inx 3218 13 second second JJ cord-010092-uftc8inx 3218 14 and and CC cord-010092-uftc8inx 3218 15 12.3 12.3 CD cord-010092-uftc8inx 3218 16 % % NN cord-010092-uftc8inx 3218 17 after after IN cord-010092-uftc8inx 3218 18 more more JJR cord-010092-uftc8inx 3218 19 than than IN cord-010092-uftc8inx 3218 20 2 2 CD cord-010092-uftc8inx 3218 21 subsequent subsequent JJ cord-010092-uftc8inx 3218 22 donations donation NNS cord-010092-uftc8inx 3218 23 . . . cord-010092-uftc8inx 3219 1 The the DT cord-010092-uftc8inx 3219 2 mean mean JJ cord-010092-uftc8inx 3219 3 age age NN cord-010092-uftc8inx 3219 4 of of IN cord-010092-uftc8inx 3219 5 blood blood NN cord-010092-uftc8inx 3219 6 donors donor NNS cord-010092-uftc8inx 3219 7 associated associate VBN cord-010092-uftc8inx 3219 8 with with IN cord-010092-uftc8inx 3219 9 PDI PDI NNP cord-010092-uftc8inx 3219 10 was be VBD cord-010092-uftc8inx 3219 11 40 40 CD cord-010092-uftc8inx 3219 12 AE AE NNP cord-010092-uftc8inx 3219 13 12 12 CD cord-010092-uftc8inx 3219 14 years year NNS cord-010092-uftc8inx 3219 15 ( ( -LRB- cord-010092-uftc8inx 3219 16 median median NN cord-010092-uftc8inx 3219 17 39 39 CD cord-010092-uftc8inx 3219 18 years year NNS cord-010092-uftc8inx 3219 19 ) ) -RRB- cord-010092-uftc8inx 3219 20 , , , cord-010092-uftc8inx 3219 21 while while IN cord-010092-uftc8inx 3219 22 the the DT cord-010092-uftc8inx 3219 23 mean mean JJ cord-010092-uftc8inx 3219 24 age age NN cord-010092-uftc8inx 3219 25 of of IN cord-010092-uftc8inx 3219 26 all all DT cord-010092-uftc8inx 3219 27 donors donor NNS cord-010092-uftc8inx 3219 28 in in IN cord-010092-uftc8inx 3219 29 2017/2018 2017/2018 CD cord-010092-uftc8inx 3219 30 was be VBD cord-010092-uftc8inx 3219 31 38 38 CD cord-010092-uftc8inx 3219 32 years year NNS cord-010092-uftc8inx 3219 33 ( ( -LRB- cord-010092-uftc8inx 3219 34 median median NN cord-010092-uftc8inx 3219 35 37 37 CD cord-010092-uftc8inx 3219 36 years year NNS cord-010092-uftc8inx 3219 37 ) ) -RRB- cord-010092-uftc8inx 3219 38 . . . cord-010092-uftc8inx 3220 1 Of of IN cord-010092-uftc8inx 3220 2 all all DT cord-010092-uftc8inx 3220 3 PDI PDI NNP cord-010092-uftc8inx 3220 4 , , , cord-010092-uftc8inx 3220 5 81.1 81.1 CD cord-010092-uftc8inx 3220 6 % % NN cord-010092-uftc8inx 3220 7 were be VBD cord-010092-uftc8inx 3220 8 related relate VBN cord-010092-uftc8inx 3220 9 to to IN cord-010092-uftc8inx 3220 10 male male JJ cord-010092-uftc8inx 3220 11 donors donor NNS cord-010092-uftc8inx 3220 12 ( ( -LRB- cord-010092-uftc8inx 3220 13 84 84 CD cord-010092-uftc8inx 3220 14 % % NN cord-010092-uftc8inx 3220 15 in in IN cord-010092-uftc8inx 3220 16 total total JJ cord-010092-uftc8inx 3220 17 pool pool NN cord-010092-uftc8inx 3220 18 of of IN cord-010092-uftc8inx 3220 19 CITM CITM NNP cord-010092-uftc8inx 3220 20 donors donor NNS cord-010092-uftc8inx 3220 21 ) ) -RRB- cord-010092-uftc8inx 3220 22 . . . cord-010092-uftc8inx 3221 1 Using use VBG cord-010092-uftc8inx 3221 2 Chi Chi NNP cord-010092-uftc8inx 3221 3 - - HYPH cord-010092-uftc8inx 3221 4 square square JJ cord-010092-uftc8inx 3221 5 test test NN cord-010092-uftc8inx 3221 6 there there EX cord-010092-uftc8inx 3221 7 were be VBD cord-010092-uftc8inx 3221 8 no no DT cord-010092-uftc8inx 3221 9 significant significant JJ cord-010092-uftc8inx 3221 10 difference difference NN cord-010092-uftc8inx 3221 11 between between IN cord-010092-uftc8inx 3221 12 female female JJ cord-010092-uftc8inx 3221 13 and and CC cord-010092-uftc8inx 3221 14 male male JJ cord-010092-uftc8inx 3221 15 donors donor NNS cord-010092-uftc8inx 3221 16 in in IN cord-010092-uftc8inx 3221 17 total total JJ cord-010092-uftc8inx 3221 18 PDI PDI NNP cord-010092-uftc8inx 3221 19 frequency frequency NN cord-010092-uftc8inx 3221 20 and and CC cord-010092-uftc8inx 3221 21 in in IN cord-010092-uftc8inx 3221 22 their -PRON- PRP$ cord-010092-uftc8inx 3221 23 distribution distribution NN cord-010092-uftc8inx 3221 24 to to IN cord-010092-uftc8inx 3221 25 early early JJ cord-010092-uftc8inx 3221 26 and and CC cord-010092-uftc8inx 3221 27 late late JJ cord-010092-uftc8inx 3221 28 PDI PDI NNP cord-010092-uftc8inx 3221 29 ( ( -LRB- cord-010092-uftc8inx 3221 30 P p NN cord-010092-uftc8inx 3221 31 > > XX cord-010092-uftc8inx 3221 32 0.05 0.05 CD cord-010092-uftc8inx 3221 33 ) ) -RRB- cord-010092-uftc8inx 3221 34 . . . cord-010092-uftc8inx 3222 1 The the DT cord-010092-uftc8inx 3222 2 median median JJ cord-010092-uftc8inx 3222 3 number number NN cord-010092-uftc8inx 3222 4 of of IN cord-010092-uftc8inx 3222 5 all all DT cord-010092-uftc8inx 3222 6 donations donation NNS cord-010092-uftc8inx 3222 7 preceding precede VBG cord-010092-uftc8inx 3222 8 PDI PDI NNP cord-010092-uftc8inx 3222 9 was be VBD cord-010092-uftc8inx 3222 10 6 6 CD cord-010092-uftc8inx 3222 11 for for IN cord-010092-uftc8inx 3222 12 female female JJ cord-010092-uftc8inx 3222 13 donors donor NNS cord-010092-uftc8inx 3222 14 and and CC cord-010092-uftc8inx 3222 15 19 19 CD cord-010092-uftc8inx 3222 16 for for IN cord-010092-uftc8inx 3222 17 male male JJ cord-010092-uftc8inx 3222 18 donors donor NNS cord-010092-uftc8inx 3222 19 . . . cord-010092-uftc8inx 3223 1 Implementation implementation NN cord-010092-uftc8inx 3223 2 of of IN cord-010092-uftc8inx 3223 3 education education NN cord-010092-uftc8inx 3223 4 leaflet leaflet NN cord-010092-uftc8inx 3223 5 for for IN cord-010092-uftc8inx 3223 6 blood blood NN cord-010092-uftc8inx 3223 7 donors donor NNS cord-010092-uftc8inx 3223 8 resulted result VBD cord-010092-uftc8inx 3223 9 in in IN cord-010092-uftc8inx 3223 10 15.4 15.4 CD cord-010092-uftc8inx 3223 11 % % NN cord-010092-uftc8inx 3223 12 reduction reduction NN cord-010092-uftc8inx 3223 13 of of IN cord-010092-uftc8inx 3223 14 PDI PDI NNP cord-010092-uftc8inx 3223 15 in in IN cord-010092-uftc8inx 3223 16 2018 2018 CD cord-010092-uftc8inx 3223 17 compared compare VBN cord-010092-uftc8inx 3223 18 with with IN cord-010092-uftc8inx 3223 19 2017 2017 CD cord-010092-uftc8inx 3223 20 ( ( -LRB- cord-010092-uftc8inx 3223 21 P p NN cord-010092-uftc8inx 3223 22 > > XX cord-010092-uftc8inx 3223 23 0.05 0.05 CD cord-010092-uftc8inx 3223 24 ) ) -RRB- cord-010092-uftc8inx 3223 25 . . . cord-010092-uftc8inx 3224 1 The the DT cord-010092-uftc8inx 3224 2 effect effect NN cord-010092-uftc8inx 3224 3 is be VBZ cord-010092-uftc8inx 3224 4 more more RBR cord-010092-uftc8inx 3224 5 pronounced pronounced JJ cord-010092-uftc8inx 3224 6 ( ( -LRB- cord-010092-uftc8inx 3224 7 P p NN cord-010092-uftc8inx 3224 8 < < XX cord-010092-uftc8inx 3224 9 0.05 0.05 CD cord-010092-uftc8inx 3224 10 ) ) -RRB- cord-010092-uftc8inx 3224 11 when when WRB cord-010092-uftc8inx 3224 12 comparing compare VBG cord-010092-uftc8inx 3224 13 second second JJ cord-010092-uftc8inx 3224 14 and and CC cord-010092-uftc8inx 3224 15 first first JJ cord-010092-uftc8inx 3224 16 half half NN cord-010092-uftc8inx 3224 17 of of IN cord-010092-uftc8inx 3224 18 2018 2018 CD cord-010092-uftc8inx 3224 19 ( ( -LRB- cord-010092-uftc8inx 3224 20 -25.6 -25.6 CD cord-010092-uftc8inx 3224 21 % % NN cord-010092-uftc8inx 3224 22 ) ) -RRB- cord-010092-uftc8inx 3224 23 . . . cord-010092-uftc8inx 3225 1 Reduction reduction NN cord-010092-uftc8inx 3225 2 is be VBZ cord-010092-uftc8inx 3225 3 observed observe VBN cord-010092-uftc8inx 3225 4 in in IN cord-010092-uftc8inx 3225 5 all all DT cord-010092-uftc8inx 3225 6 types type NNS cord-010092-uftc8inx 3225 7 of of IN cord-010092-uftc8inx 3225 8 PDI PDI NNP cord-010092-uftc8inx 3225 9 with with IN cord-010092-uftc8inx 3225 10 the the DT cord-010092-uftc8inx 3225 11 exception exception NN cord-010092-uftc8inx 3225 12 of of IN cord-010092-uftc8inx 3225 13 infections infection NNS cord-010092-uftc8inx 3225 14 / / SYM cord-010092-uftc8inx 3225 15 contact contact NN cord-010092-uftc8inx 3225 16 ( ( -LRB- cord-010092-uftc8inx 3225 17 because because IN cord-010092-uftc8inx 3225 18 they -PRON- PRP cord-010092-uftc8inx 3225 19 are be VBP cord-010092-uftc8inx 3225 20 mostly mostly RB cord-010092-uftc8inx 3225 21 early early JJ cord-010092-uftc8inx 3225 22 PDI PDI NNP cord-010092-uftc8inx 3225 23 ) ) -RRB- cord-010092-uftc8inx 3225 24 and and CC cord-010092-uftc8inx 3225 25 malignant malignant JJ cord-010092-uftc8inx 3225 26 diseases disease NNS cord-010092-uftc8inx 3225 27 . . . cord-010092-uftc8inx 3226 1 The the DT cord-010092-uftc8inx 3226 2 share share NN cord-010092-uftc8inx 3226 3 of of IN cord-010092-uftc8inx 3226 4 early early JJ cord-010092-uftc8inx 3226 5 PDI PDI NNP cord-010092-uftc8inx 3226 6 increased increase VBD cord-010092-uftc8inx 3226 7 from from IN cord-010092-uftc8inx 3226 8 21.1 21.1 CD cord-010092-uftc8inx 3226 9 % % NN cord-010092-uftc8inx 3226 10 in in IN cord-010092-uftc8inx 3226 11 2017 2017 CD cord-010092-uftc8inx 3226 12 to to IN cord-010092-uftc8inx 3226 13 26.7 26.7 CD cord-010092-uftc8inx 3226 14 % % NN cord-010092-uftc8inx 3226 15 in in IN cord-010092-uftc8inx 3226 16 2018 2018 CD cord-010092-uftc8inx 3226 17 , , , cord-010092-uftc8inx 3226 18 which which WDT cord-010092-uftc8inx 3226 19 may may MD cord-010092-uftc8inx 3226 20 suggest suggest VB cord-010092-uftc8inx 3226 21 better well JJR cord-010092-uftc8inx 3226 22 awareness awareness NN cord-010092-uftc8inx 3226 23 of of IN cord-010092-uftc8inx 3226 24 blood blood NN cord-010092-uftc8inx 3226 25 donors donor NNS cord-010092-uftc8inx 3226 26 on on IN cord-010092-uftc8inx 3226 27 the the DT cord-010092-uftc8inx 3226 28 importance importance NN cord-010092-uftc8inx 3226 29 to to TO cord-010092-uftc8inx 3226 30 inform inform VB cord-010092-uftc8inx 3226 31 blood blood NN cord-010092-uftc8inx 3226 32 bank bank NN cord-010092-uftc8inx 3226 33 on on IN cord-010092-uftc8inx 3226 34 changes change NNS cord-010092-uftc8inx 3226 35 in in IN cord-010092-uftc8inx 3226 36 their -PRON- PRP$ cord-010092-uftc8inx 3226 37 health health NN cord-010092-uftc8inx 3226 38 status status NN cord-010092-uftc8inx 3226 39 . . . cord-010092-uftc8inx 3227 1 Summary Summary NNP cord-010092-uftc8inx 3227 2 / / SYM cord-010092-uftc8inx 3227 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 3227 4 : : : cord-010092-uftc8inx 3228 1 Our -PRON- PRP$ cord-010092-uftc8inx 3228 2 study study NN cord-010092-uftc8inx 3228 3 points point VBZ cord-010092-uftc8inx 3228 4 to to IN cord-010092-uftc8inx 3228 5 the the DT cord-010092-uftc8inx 3228 6 importance importance NN cord-010092-uftc8inx 3228 7 of of IN cord-010092-uftc8inx 3228 8 systematic systematic JJ cord-010092-uftc8inx 3228 9 recording recording NN cord-010092-uftc8inx 3228 10 and and CC cord-010092-uftc8inx 3228 11 management management NN cord-010092-uftc8inx 3228 12 of of IN cord-010092-uftc8inx 3228 13 PDI PDI NNP cord-010092-uftc8inx 3228 14 , , , cord-010092-uftc8inx 3228 15 including include VBG cord-010092-uftc8inx 3228 16 education education NN cord-010092-uftc8inx 3228 17 of of IN cord-010092-uftc8inx 3228 18 blood blood NN cord-010092-uftc8inx 3228 19 donors donor NNS cord-010092-uftc8inx 3228 20 about about IN cord-010092-uftc8inx 3228 21 the the DT cord-010092-uftc8inx 3228 22 need need NN cord-010092-uftc8inx 3228 23 of of IN cord-010092-uftc8inx 3228 24 providing provide VBG cord-010092-uftc8inx 3228 25 all all DT cord-010092-uftc8inx 3228 26 relevant relevant JJ cord-010092-uftc8inx 3228 27 facts fact NNS cord-010092-uftc8inx 3228 28 related relate VBN cord-010092-uftc8inx 3228 29 to to IN cord-010092-uftc8inx 3228 30 their -PRON- PRP$ cord-010092-uftc8inx 3228 31 health health NN cord-010092-uftc8inx 3228 32 and and CC cord-010092-uftc8inx 3228 33 the the DT cord-010092-uftc8inx 3228 34 safety safety NN cord-010092-uftc8inx 3228 35 of of IN cord-010092-uftc8inx 3228 36 donated donate VBN cord-010092-uftc8inx 3228 37 blood blood NN cord-010092-uftc8inx 3228 38 in in IN cord-010092-uftc8inx 3228 39 a a DT cord-010092-uftc8inx 3228 40 timely timely JJ cord-010092-uftc8inx 3228 41 manner manner NN cord-010092-uftc8inx 3228 42 . . . cord-010092-uftc8inx 3229 1 We -PRON- PRP cord-010092-uftc8inx 3229 2 are be VBP cord-010092-uftc8inx 3229 3 planning plan VBG cord-010092-uftc8inx 3229 4 further further JJ cord-010092-uftc8inx 3229 5 improvements improvement NNS cord-010092-uftc8inx 3229 6 by by IN cord-010092-uftc8inx 3229 7 providing provide VBG cord-010092-uftc8inx 3229 8 information information NN cord-010092-uftc8inx 3229 9 on on IN cord-010092-uftc8inx 3229 10 this this DT cord-010092-uftc8inx 3229 11 topic topic NN cord-010092-uftc8inx 3229 12 on on IN cord-010092-uftc8inx 3229 13 posters poster NNS cord-010092-uftc8inx 3229 14 and and CC cord-010092-uftc8inx 3229 15 screens screen NNS cord-010092-uftc8inx 3229 16 on on IN cord-010092-uftc8inx 3229 17 donation donation NN cord-010092-uftc8inx 3229 18 sites site NNS cord-010092-uftc8inx 3229 19 . . . cord-010092-uftc8inx 3230 1 Background background NN cord-010092-uftc8inx 3230 2 : : : cord-010092-uftc8inx 3231 1 Currently currently RB cord-010092-uftc8inx 3231 2 , , , cord-010092-uftc8inx 3231 3 the the DT cord-010092-uftc8inx 3231 4 transfer transfer NN cord-010092-uftc8inx 3231 5 of of IN cord-010092-uftc8inx 3231 6 data datum NNS cord-010092-uftc8inx 3231 7 between between IN cord-010092-uftc8inx 3231 8 organizations organization NNS cord-010092-uftc8inx 3231 9 and/or and/or CC cord-010092-uftc8inx 3231 10 computer computer NN cord-010092-uftc8inx 3231 11 systems system NNS cord-010092-uftc8inx 3231 12 is be VBZ cord-010092-uftc8inx 3231 13 very very RB cord-010092-uftc8inx 3231 14 limited limited JJ cord-010092-uftc8inx 3231 15 , , , cord-010092-uftc8inx 3231 16 and and CC cord-010092-uftc8inx 3231 17 where where WRB cord-010092-uftc8inx 3231 18 present present JJ cord-010092-uftc8inx 3231 19 is be VBZ cord-010092-uftc8inx 3231 20 typically typically RB cord-010092-uftc8inx 3231 21 proprietary proprietary JJ cord-010092-uftc8inx 3231 22 . . . cord-010092-uftc8inx 3232 1 In in IN cord-010092-uftc8inx 3232 2 the the DT cord-010092-uftc8inx 3232 3 absence absence NN cord-010092-uftc8inx 3232 4 of of IN cord-010092-uftc8inx 3232 5 a a DT cord-010092-uftc8inx 3232 6 standardized standardized JJ cord-010092-uftc8inx 3232 7 reference reference NN cord-010092-uftc8inx 3232 8 format format NN cord-010092-uftc8inx 3232 9 individual individual JJ cord-010092-uftc8inx 3232 10 organizations organization NNS cord-010092-uftc8inx 3232 11 and and CC cord-010092-uftc8inx 3232 12 vendors vendor NNS cord-010092-uftc8inx 3232 13 attempting attempt VBG cord-010092-uftc8inx 3232 14 to to TO cord-010092-uftc8inx 3232 15 integrate integrate VB cord-010092-uftc8inx 3232 16 disparate disparate JJ cord-010092-uftc8inx 3232 17 databases database NNS cord-010092-uftc8inx 3232 18 must must MD cord-010092-uftc8inx 3232 19 develop develop VB cord-010092-uftc8inx 3232 20 unique unique JJ cord-010092-uftc8inx 3232 21 solutions solution NNS cord-010092-uftc8inx 3232 22 . . . cord-010092-uftc8inx 3233 1 Aggregation aggregation NN cord-010092-uftc8inx 3233 2 of of IN cord-010092-uftc8inx 3233 3 information information NN cord-010092-uftc8inx 3233 4 from from IN cord-010092-uftc8inx 3233 5 multiple multiple JJ cord-010092-uftc8inx 3233 6 sources source NNS cord-010092-uftc8inx 3233 7 is be VBZ cord-010092-uftc8inx 3233 8 complex complex JJ cord-010092-uftc8inx 3233 9 and and CC cord-010092-uftc8inx 3233 10 costly costly JJ cord-010092-uftc8inx 3233 11 , , , cord-010092-uftc8inx 3233 12 constituting constitute VBG cord-010092-uftc8inx 3233 13 a a DT cord-010092-uftc8inx 3233 14 significant significant JJ cord-010092-uftc8inx 3233 15 barrier barrier NN cord-010092-uftc8inx 3233 16 to to IN cord-010092-uftc8inx 3233 17 effective effective JJ cord-010092-uftc8inx 3233 18 analysis analysis NN cord-010092-uftc8inx 3233 19 of of IN cord-010092-uftc8inx 3233 20 data datum NNS cord-010092-uftc8inx 3233 21 to to TO cord-010092-uftc8inx 3233 22 improve improve VB cord-010092-uftc8inx 3233 23 practice practice NN cord-010092-uftc8inx 3233 24 and and CC cord-010092-uftc8inx 3233 25 inform inform VB cord-010092-uftc8inx 3233 26 policy policy NN cord-010092-uftc8inx 3233 27 . . . cord-010092-uftc8inx 3234 1 Aims aim VBZ cord-010092-uftc8inx 3234 2 : : : cord-010092-uftc8inx 3235 1 To to TO cord-010092-uftc8inx 3235 2 standardize standardize VB cord-010092-uftc8inx 3235 3 the the DT cord-010092-uftc8inx 3235 4 definitions definition NNS cord-010092-uftc8inx 3235 5 and and CC cord-010092-uftc8inx 3235 6 facilitate facilitate VB cord-010092-uftc8inx 3235 7 integration integration NN cord-010092-uftc8inx 3235 8 of of IN cord-010092-uftc8inx 3235 9 key key JJ cord-010092-uftc8inx 3235 10 data datum NNS cord-010092-uftc8inx 3235 11 items item NNS cord-010092-uftc8inx 3235 12 used use VBN cord-010092-uftc8inx 3235 13 in in IN cord-010092-uftc8inx 3235 14 blood blood NN cord-010092-uftc8inx 3235 15 donation donation NN cord-010092-uftc8inx 3235 16 and and CC cord-010092-uftc8inx 3235 17 transfusion transfusion NN cord-010092-uftc8inx 3235 18 . . . cord-010092-uftc8inx 3236 1 We -PRON- PRP cord-010092-uftc8inx 3236 2 report report VBP cord-010092-uftc8inx 3236 3 here here RB cord-010092-uftc8inx 3236 4 on on IN cord-010092-uftc8inx 3236 5 an an DT cord-010092-uftc8inx 3236 6 initial initial JJ cord-010092-uftc8inx 3236 7 effort effort NN cord-010092-uftc8inx 3236 8 to to TO cord-010092-uftc8inx 3236 9 map map VB cord-010092-uftc8inx 3236 10 internationally internationally RB cord-010092-uftc8inx 3236 11 harmonized harmonize VBN cord-010092-uftc8inx 3236 12 critical critical JJ cord-010092-uftc8inx 3236 13 steps step NNS cord-010092-uftc8inx 3236 14 in in IN cord-010092-uftc8inx 3236 15 the the DT cord-010092-uftc8inx 3236 16 blood blood NN cord-010092-uftc8inx 3236 17 collection collection NN cord-010092-uftc8inx 3236 18 / / SYM cord-010092-uftc8inx 3236 19 donation donation NN cord-010092-uftc8inx 3236 20 process process NN cord-010092-uftc8inx 3236 21 in in IN cord-010092-uftc8inx 3236 22 order order NN cord-010092-uftc8inx 3236 23 to to TO cord-010092-uftc8inx 3236 24 test test VB cord-010092-uftc8inx 3236 25 the the DT cord-010092-uftc8inx 3236 26 approach approach NN cord-010092-uftc8inx 3236 27 . . . cord-010092-uftc8inx 3237 1 Methods method NNS cord-010092-uftc8inx 3237 2 : : : cord-010092-uftc8inx 3237 3 Through through IN cord-010092-uftc8inx 3237 4 a a DT cord-010092-uftc8inx 3237 5 collaborative collaborative JJ cord-010092-uftc8inx 3237 6 process process NN cord-010092-uftc8inx 3237 7 of of IN cord-010092-uftc8inx 3237 8 serial serial JJ cord-010092-uftc8inx 3237 9 conference conference NN cord-010092-uftc8inx 3237 10 calls call NNS cord-010092-uftc8inx 3237 11 and and CC cord-010092-uftc8inx 3237 12 correspondence correspondence NN cord-010092-uftc8inx 3237 13 , , , cord-010092-uftc8inx 3237 14 an an DT cord-010092-uftc8inx 3237 15 informal informal JJ cord-010092-uftc8inx 3237 16 multi multi JJ cord-010092-uftc8inx 3237 17 - - JJ cord-010092-uftc8inx 3237 18 national national JJ cord-010092-uftc8inx 3237 19 consortium consortium NN cord-010092-uftc8inx 3237 20 of of IN cord-010092-uftc8inx 3237 21 experts expert NNS cord-010092-uftc8inx 3237 22 across across IN cord-010092-uftc8inx 3237 23 the the DT cord-010092-uftc8inx 3237 24 transfusion transfusion NN cord-010092-uftc8inx 3237 25 industry industry NN cord-010092-uftc8inx 3237 26 are be VBP cord-010092-uftc8inx 3237 27 attempting attempt VBG cord-010092-uftc8inx 3237 28 to to TO cord-010092-uftc8inx 3237 29 create create VB cord-010092-uftc8inx 3237 30 a a DT cord-010092-uftc8inx 3237 31 vocabulary vocabulary NN cord-010092-uftc8inx 3237 32 with with IN cord-010092-uftc8inx 3237 33 sufficiently sufficiently RB cord-010092-uftc8inx 3237 34 precise precise JJ cord-010092-uftc8inx 3237 35 definitions definition NNS cord-010092-uftc8inx 3237 36 to to TO cord-010092-uftc8inx 3237 37 be be VB cord-010092-uftc8inx 3237 38 usable usable JJ cord-010092-uftc8inx 3237 39 by by IN cord-010092-uftc8inx 3237 40 automated automate VBN cord-010092-uftc8inx 3237 41 systems system NNS cord-010092-uftc8inx 3237 42 and and CC cord-010092-uftc8inx 3237 43 that that DT cord-010092-uftc8inx 3237 44 can can MD cord-010092-uftc8inx 3237 45 be be VB cord-010092-uftc8inx 3237 46 the the DT cord-010092-uftc8inx 3237 47 foundation foundation NN cord-010092-uftc8inx 3237 48 of of IN cord-010092-uftc8inx 3237 49 a a DT cord-010092-uftc8inx 3237 50 Blood Blood NNP cord-010092-uftc8inx 3237 51 Collection Collection NNP cord-010092-uftc8inx 3237 52 / / SYM cord-010092-uftc8inx 3237 53 Transfusion Transfusion NNP cord-010092-uftc8inx 3237 54 Medicine Medicine NNP cord-010092-uftc8inx 3237 55 Common Common NNP cord-010092-uftc8inx 3237 56 Data Data NNP cord-010092-uftc8inx 3237 57 Model Model NNP cord-010092-uftc8inx 3237 58 ( ( -LRB- cord-010092-uftc8inx 3237 59 CDM CDM NNP cord-010092-uftc8inx 3237 60 ) ) -RRB- cord-010092-uftc8inx 3237 61 , , , cord-010092-uftc8inx 3237 62 using use VBG cord-010092-uftc8inx 3237 63 the the DT cord-010092-uftc8inx 3237 64 following follow VBG cord-010092-uftc8inx 3237 65 steps step NNS cord-010092-uftc8inx 3237 66 : : : cord-010092-uftc8inx 3237 67 -Define -Define NFP cord-010092-uftc8inx 3237 68 the the DT cord-010092-uftc8inx 3237 69 scope scope NN cord-010092-uftc8inx 3237 70 of of IN cord-010092-uftc8inx 3237 71 activity activity NN cord-010092-uftc8inx 3237 72 to to TO cord-010092-uftc8inx 3237 73 be be VB cord-010092-uftc8inx 3237 74 addressed address VBN cord-010092-uftc8inx 3237 75 and and CC cord-010092-uftc8inx 3237 76 segment segment NN cord-010092-uftc8inx 3237 77 into into IN cord-010092-uftc8inx 3237 78 key key JJ cord-010092-uftc8inx 3237 79 processes process NNS cord-010092-uftc8inx 3237 80 . . . cord-010092-uftc8inx 3238 1 -Identify -Identify : cord-010092-uftc8inx 3238 2 the the DT cord-010092-uftc8inx 3238 3 set set NN cord-010092-uftc8inx 3238 4 of of IN cord-010092-uftc8inx 3238 5 data datum NNS cord-010092-uftc8inx 3238 6 elements element NNS cord-010092-uftc8inx 3238 7 in in IN cord-010092-uftc8inx 3238 8 each each DT cord-010092-uftc8inx 3238 9 segment segment NN cord-010092-uftc8inx 3238 10 that that WDT cord-010092-uftc8inx 3238 11 are be VBP cord-010092-uftc8inx 3238 12 common common JJ cord-010092-uftc8inx 3238 13 to to IN cord-010092-uftc8inx 3238 14 all all DT cord-010092-uftc8inx 3238 15 systems system NNS cord-010092-uftc8inx 3238 16 . . . cord-010092-uftc8inx 3239 1 -Review -Review : cord-010092-uftc8inx 3239 2 and and CC cord-010092-uftc8inx 3239 3 consider consider VB cord-010092-uftc8inx 3239 4 existing exist VBG cord-010092-uftc8inx 3239 5 standards standard NNS cord-010092-uftc8inx 3239 6 and and CC cord-010092-uftc8inx 3239 7 definitions definition NNS cord-010092-uftc8inx 3239 8 for for IN cord-010092-uftc8inx 3239 9 each each DT cord-010092-uftc8inx 3239 10 data data NN cord-010092-uftc8inx 3239 11 element element NN cord-010092-uftc8inx 3239 12 . . . cord-010092-uftc8inx 3240 1 -Develop -Develop : cord-010092-uftc8inx 3240 2 draft draft NN cord-010092-uftc8inx 3240 3 definitions definition NNS cord-010092-uftc8inx 3240 4 for for IN cord-010092-uftc8inx 3240 5 each each DT cord-010092-uftc8inx 3240 6 data data NN cord-010092-uftc8inx 3240 7 element element NN cord-010092-uftc8inx 3240 8 . . . cord-010092-uftc8inx 3241 1 -Release -Release : cord-010092-uftc8inx 3241 2 draft draft NN cord-010092-uftc8inx 3241 3 to to IN cord-010092-uftc8inx 3241 4 public public JJ cord-010092-uftc8inx 3241 5 domain domain NN cord-010092-uftc8inx 3241 6 for for IN cord-010092-uftc8inx 3241 7 critical critical JJ cord-010092-uftc8inx 3241 8 review review NN cord-010092-uftc8inx 3241 9 and and CC cord-010092-uftc8inx 3241 10 refinement refinement NN cord-010092-uftc8inx 3241 11 with with IN cord-010092-uftc8inx 3241 12 long long JJ cord-010092-uftc8inx 3241 13 - - HYPH cord-010092-uftc8inx 3241 14 term term NN cord-010092-uftc8inx 3241 15 goal goal NN cord-010092-uftc8inx 3241 16 of of IN cord-010092-uftc8inx 3241 17 gaining gain VBG cord-010092-uftc8inx 3241 18 widespread widespread JJ cord-010092-uftc8inx 3241 19 endorsement endorsement NN cord-010092-uftc8inx 3241 20 . . . cord-010092-uftc8inx 3242 1 Results result NNS cord-010092-uftc8inx 3242 2 : : : cord-010092-uftc8inx 3243 1 A a DT cord-010092-uftc8inx 3243 2 standardized standardized JJ cord-010092-uftc8inx 3243 3 approach approach NN cord-010092-uftc8inx 3243 4 to to IN cord-010092-uftc8inx 3243 5 blood blood NN cord-010092-uftc8inx 3243 6 donation donation NN cord-010092-uftc8inx 3243 7 was be VBD cord-010092-uftc8inx 3243 8 mapped map VBN cord-010092-uftc8inx 3243 9 through through IN cord-010092-uftc8inx 3243 10 identification identification NN cord-010092-uftc8inx 3243 11 of of IN cord-010092-uftc8inx 3243 12 common common JJ cord-010092-uftc8inx 3243 13 pathways pathway NNS cord-010092-uftc8inx 3243 14 and and CC cord-010092-uftc8inx 3243 15 core core JJ cord-010092-uftc8inx 3243 16 mappable mappable JJ cord-010092-uftc8inx 3243 17 data datum NNS cord-010092-uftc8inx 3243 18 elements element NNS cord-010092-uftc8inx 3243 19 . . . cord-010092-uftc8inx 3244 1 Denominator denominator NN cord-010092-uftc8inx 3244 2 data datum NNS cord-010092-uftc8inx 3244 3 associated associate VBN cord-010092-uftc8inx 3244 4 with with IN cord-010092-uftc8inx 3244 5 donor donor NN cord-010092-uftc8inx 3244 6 characteristics characteristic NNS cord-010092-uftc8inx 3244 7 and and CC cord-010092-uftc8inx 3244 8 blood blood NN cord-010092-uftc8inx 3244 9 collection collection NN cord-010092-uftc8inx 3244 10 was be VBD cord-010092-uftc8inx 3244 11 selected select VBN cord-010092-uftc8inx 3244 12 as as IN cord-010092-uftc8inx 3244 13 the the DT cord-010092-uftc8inx 3244 14 first first JJ cord-010092-uftc8inx 3244 15 segment segment NN cord-010092-uftc8inx 3244 16 to to TO cord-010092-uftc8inx 3244 17 address address VB cord-010092-uftc8inx 3244 18 . . . cord-010092-uftc8inx 3245 1 A a DT cord-010092-uftc8inx 3245 2 dictionary dictionary NN cord-010092-uftc8inx 3245 3 ( ( -LRB- cord-010092-uftc8inx 3245 4 or or CC cord-010092-uftc8inx 3245 5 vocabulary vocabulary NN cord-010092-uftc8inx 3245 6 ) ) -RRB- cord-010092-uftc8inx 3245 7 of of IN cord-010092-uftc8inx 3245 8 common common JJ cord-010092-uftc8inx 3245 9 terms term NNS cord-010092-uftc8inx 3245 10 has have VBZ cord-010092-uftc8inx 3245 11 been be VBN cord-010092-uftc8inx 3245 12 created create VBN cord-010092-uftc8inx 3245 13 and and CC cord-010092-uftc8inx 3245 14 will will MD cord-010092-uftc8inx 3245 15 be be VB cord-010092-uftc8inx 3245 16 presented present VBN cord-010092-uftc8inx 3245 17 for for IN cord-010092-uftc8inx 3245 18 international international JJ cord-010092-uftc8inx 3245 19 comment comment NN cord-010092-uftc8inx 3245 20 . . . cord-010092-uftc8inx 3246 1 Summary Summary NNP cord-010092-uftc8inx 3246 2 / / SYM cord-010092-uftc8inx 3246 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 3246 4 : : : cord-010092-uftc8inx 3247 1 Developing develop VBG cord-010092-uftc8inx 3247 2 an an DT cord-010092-uftc8inx 3247 3 international international JJ cord-010092-uftc8inx 3247 4 consensus consensus NN cord-010092-uftc8inx 3247 5 on on IN cord-010092-uftc8inx 3247 6 the the DT cord-010092-uftc8inx 3247 7 core core NN cord-010092-uftc8inx 3247 8 elements element NNS cord-010092-uftc8inx 3247 9 and and CC cord-010092-uftc8inx 3247 10 their -PRON- PRP$ cord-010092-uftc8inx 3247 11 definitions definition NNS cord-010092-uftc8inx 3247 12 across across IN cord-010092-uftc8inx 3247 13 the the DT cord-010092-uftc8inx 3247 14 transfusion transfusion NN cord-010092-uftc8inx 3247 15 chain chain NN cord-010092-uftc8inx 3247 16 is be VBZ cord-010092-uftc8inx 3247 17 critical critical JJ cord-010092-uftc8inx 3247 18 for for IN cord-010092-uftc8inx 3247 19 data data NN cord-010092-uftc8inx 3247 20 integration integration NN cord-010092-uftc8inx 3247 21 and and CC cord-010092-uftc8inx 3247 22 automation automation NN cord-010092-uftc8inx 3247 23 efforts effort NNS cord-010092-uftc8inx 3247 24 . . . cord-010092-uftc8inx 3248 1 The the DT cord-010092-uftc8inx 3248 2 expected expect VBN cord-010092-uftc8inx 3248 3 benefits benefit NNS cord-010092-uftc8inx 3248 4 of of IN cord-010092-uftc8inx 3248 5 this this DT cord-010092-uftc8inx 3248 6 endeavor endeavor NN cord-010092-uftc8inx 3248 7 include include VBP cord-010092-uftc8inx 3248 8 that that IN cord-010092-uftc8inx 3248 9 it -PRON- PRP cord-010092-uftc8inx 3248 10 allows allow VBZ cord-010092-uftc8inx 3248 11 the the DT cord-010092-uftc8inx 3248 12 establishment establishment NN cord-010092-uftc8inx 3248 13 of of IN cord-010092-uftc8inx 3248 14 algorithms algorithm NNS cord-010092-uftc8inx 3248 15 to to TO cord-010092-uftc8inx 3248 16 automate automate VB cord-010092-uftc8inx 3248 17 reporting reporting NN cord-010092-uftc8inx 3248 18 and and CC cord-010092-uftc8inx 3248 19 thus thus RB cord-010092-uftc8inx 3248 20 reduce reduce VB cord-010092-uftc8inx 3248 21 hands hand NNS cord-010092-uftc8inx 3248 22 - - HYPH cord-010092-uftc8inx 3248 23 on on RP cord-010092-uftc8inx 3248 24 staff staff NN cord-010092-uftc8inx 3248 25 time time NN cord-010092-uftc8inx 3248 26 ; ; : cord-010092-uftc8inx 3248 27 reduces reduce VBZ cord-010092-uftc8inx 3248 28 time time NN cord-010092-uftc8inx 3248 29 and and CC cord-010092-uftc8inx 3248 30 resources resource NNS cord-010092-uftc8inx 3248 31 needed need VBN cord-010092-uftc8inx 3248 32 to to TO cord-010092-uftc8inx 3248 33 integrate integrate VB cord-010092-uftc8inx 3248 34 new new JJ cord-010092-uftc8inx 3248 35 databases database NNS cord-010092-uftc8inx 3248 36 ; ; , cord-010092-uftc8inx 3248 37 allows allow VBZ cord-010092-uftc8inx 3248 38 systems system NNS cord-010092-uftc8inx 3248 39 to to TO cord-010092-uftc8inx 3248 40 continue continue VB cord-010092-uftc8inx 3248 41 to to TO cord-010092-uftc8inx 3248 42 use use VB cord-010092-uftc8inx 3248 43 existing exist VBG cord-010092-uftc8inx 3248 44 concepts concept NNS cord-010092-uftc8inx 3248 45 and and CC cord-010092-uftc8inx 3248 46 definitions definition NNS cord-010092-uftc8inx 3248 47 internally internally RB cord-010092-uftc8inx 3248 48 while while IN cord-010092-uftc8inx 3248 49 also also RB cord-010092-uftc8inx 3248 50 providing provide VBG cord-010092-uftc8inx 3248 51 data data NN cord-010092-uftc8inx 3248 52 output output NN cord-010092-uftc8inx 3248 53 in in IN cord-010092-uftc8inx 3248 54 a a DT cord-010092-uftc8inx 3248 55 standardized standardized JJ cord-010092-uftc8inx 3248 56 format format NN cord-010092-uftc8inx 3248 57 ; ; : cord-010092-uftc8inx 3248 58 supports support VBZ cord-010092-uftc8inx 3248 59 the the DT cord-010092-uftc8inx 3248 60 ability ability NN cord-010092-uftc8inx 3248 61 to to TO cord-010092-uftc8inx 3248 62 consistently consistently RB cord-010092-uftc8inx 3248 63 analyse analyse VB cord-010092-uftc8inx 3248 64 , , , cord-010092-uftc8inx 3248 65 interpret interpret VB cord-010092-uftc8inx 3248 66 and and CC cord-010092-uftc8inx 3248 67 present present JJ cord-010092-uftc8inx 3248 68 information information NN cord-010092-uftc8inx 3248 69 regardless regardless RB cord-010092-uftc8inx 3248 70 of of IN cord-010092-uftc8inx 3248 71 the the DT cord-010092-uftc8inx 3248 72 data data NN cord-010092-uftc8inx 3248 73 source source NN cord-010092-uftc8inx 3248 74 ; ; : cord-010092-uftc8inx 3248 75 establishes establish VBZ cord-010092-uftc8inx 3248 76 data data NN cord-010092-uftc8inx 3248 77 definitions definition NNS cord-010092-uftc8inx 3248 78 against against IN cord-010092-uftc8inx 3248 79 which which WDT cord-010092-uftc8inx 3248 80 new new JJ cord-010092-uftc8inx 3248 81 systems system NNS cord-010092-uftc8inx 3248 82 can can MD cord-010092-uftc8inx 3248 83 be be VB cord-010092-uftc8inx 3248 84 developed develop VBN cord-010092-uftc8inx 3248 85 ; ; : cord-010092-uftc8inx 3248 86 helps help VBZ cord-010092-uftc8inx 3248 87 to to TO cord-010092-uftc8inx 3248 88 improve improve VB cord-010092-uftc8inx 3248 89 comparability comparability NN cord-010092-uftc8inx 3248 90 of of IN cord-010092-uftc8inx 3248 91 results result NNS cord-010092-uftc8inx 3248 92 by by IN cord-010092-uftc8inx 3248 93 providing provide VBG cord-010092-uftc8inx 3248 94 a a DT cord-010092-uftc8inx 3248 95 common common JJ cord-010092-uftc8inx 3248 96 data data NN cord-010092-uftc8inx 3248 97 model model NN cord-010092-uftc8inx 3248 98 for for IN cord-010092-uftc8inx 3248 99 researchers researcher NNS cord-010092-uftc8inx 3248 100 and and CC cord-010092-uftc8inx 3248 101 policy policy NN cord-010092-uftc8inx 3248 102 makers maker NNS cord-010092-uftc8inx 3248 103 ; ; : cord-010092-uftc8inx 3248 104 improves improve VBZ cord-010092-uftc8inx 3248 105 confidence confidence NN cord-010092-uftc8inx 3248 106 in in IN cord-010092-uftc8inx 3248 107 data datum NNS cord-010092-uftc8inx 3248 108 integrity integrity NN cord-010092-uftc8inx 3248 109 and and CC cord-010092-uftc8inx 3248 110 reliability reliability NN cord-010092-uftc8inx 3248 111 of of IN cord-010092-uftc8inx 3248 112 the the DT cord-010092-uftc8inx 3248 113 derived derive VBN cord-010092-uftc8inx 3248 114 information information NN cord-010092-uftc8inx 3248 115 as as IN cord-010092-uftc8inx 3248 116 a a DT cord-010092-uftc8inx 3248 117 © © NNP cord-010092-uftc8inx 3248 118 2019 2019 CD cord-010092-uftc8inx 3249 1 The the DT cord-010092-uftc8inx 3249 2 Authors author NNS cord-010092-uftc8inx 3249 3 Vox Vox NNP cord-010092-uftc8inx 3249 4 Sanguinis Sanguinis NNP cord-010092-uftc8inx 3249 5 © © NN cord-010092-uftc8inx 3250 1 2019 2019 CD cord-010092-uftc8inx 3250 2 International International NNP cord-010092-uftc8inx 3250 3 Society Society NNP cord-010092-uftc8inx 3250 4 of of IN cord-010092-uftc8inx 3250 5 Blood Blood NNP cord-010092-uftc8inx 3250 6 Transfusion Transfusion NNP cord-010092-uftc8inx 3250 7 Vox Vox NNP cord-010092-uftc8inx 3250 8 Sanguinis Sanguinis NNP cord-010092-uftc8inx 3250 9 ( ( -LRB- cord-010092-uftc8inx 3250 10 2019 2019 CD cord-010092-uftc8inx 3250 11 ) ) -RRB- cord-010092-uftc8inx 3250 12 114 114 CD cord-010092-uftc8inx 3251 1 ( ( -LRB- cord-010092-uftc8inx 3251 2 Suppl Suppl NNP cord-010092-uftc8inx 3251 3 . . . cord-010092-uftc8inx 3252 1 1 1 LS cord-010092-uftc8inx 3252 2 ) ) -RRB- cord-010092-uftc8inx 3252 3 , , , cord-010092-uftc8inx 3252 4 5 5 CD cord-010092-uftc8inx 3252 5 - - SYM cord-010092-uftc8inx 3252 6 240 240 CD cord-010092-uftc8inx 3252 7 basis basis NN cord-010092-uftc8inx 3252 8 for for IN cord-010092-uftc8inx 3252 9 rational rational JJ cord-010092-uftc8inx 3252 10 decision decision NN cord-010092-uftc8inx 3252 11 making making NN cord-010092-uftc8inx 3252 12 ; ; : cord-010092-uftc8inx 3252 13 and and CC cord-010092-uftc8inx 3252 14 reduces reduce VBZ cord-010092-uftc8inx 3252 15 data datum NNS cord-010092-uftc8inx 3252 16 gathering gathering NN cord-010092-uftc8inx 3252 17 effort effort NN cord-010092-uftc8inx 3252 18 and and CC cord-010092-uftc8inx 3252 19 cost cost NN cord-010092-uftc8inx 3252 20 thus thus RB cord-010092-uftc8inx 3252 21 improving improve VBG cord-010092-uftc8inx 3252 22 opportunities opportunity NNS cord-010092-uftc8inx 3252 23 for for IN cord-010092-uftc8inx 3252 24 more more RBR cord-010092-uftc8inx 3252 25 efficient efficient JJ cord-010092-uftc8inx 3252 26 / / SYM cord-010092-uftc8inx 3252 27 complex complex JJ cord-010092-uftc8inx 3252 28 data data NN cord-010092-uftc8inx 3252 29 analysis analysis NN cord-010092-uftc8inx 3252 30 . . . cord-010092-uftc8inx 3253 1 Standardizing standardize VBG cord-010092-uftc8inx 3253 2 the the DT cord-010092-uftc8inx 3253 3 transfusion transfusion NN cord-010092-uftc8inx 3253 4 medicine medicine NN cord-010092-uftc8inx 3253 5 dataset dataset NN cord-010092-uftc8inx 3253 6 is be VBZ cord-010092-uftc8inx 3253 7 the the DT cord-010092-uftc8inx 3253 8 first first JJ cord-010092-uftc8inx 3253 9 step step NN cord-010092-uftc8inx 3253 10 in in IN cord-010092-uftc8inx 3253 11 achieving achieve VBG cord-010092-uftc8inx 3253 12 the the DT cord-010092-uftc8inx 3253 13 automation automation NN cord-010092-uftc8inx 3253 14 of of IN cord-010092-uftc8inx 3253 15 data datum NNS cord-010092-uftc8inx 3253 16 transfer transfer NN cord-010092-uftc8inx 3253 17 and and CC cord-010092-uftc8inx 3253 18 analysis analysis NN cord-010092-uftc8inx 3253 19 needed need VBN cord-010092-uftc8inx 3253 20 globally globally RB cord-010092-uftc8inx 3253 21 to to TO cord-010092-uftc8inx 3253 22 drive drive VB cord-010092-uftc8inx 3253 23 patient patient JJ cord-010092-uftc8inx 3253 24 safety safety NN cord-010092-uftc8inx 3253 25 , , , cord-010092-uftc8inx 3253 26 research research NN cord-010092-uftc8inx 3253 27 innovation innovation NN cord-010092-uftc8inx 3253 28 , , , cord-010092-uftc8inx 3253 29 and and CC cord-010092-uftc8inx 3253 30 best good JJS cord-010092-uftc8inx 3253 31 business business NN cord-010092-uftc8inx 3253 32 practices practice NNS cord-010092-uftc8inx 3253 33 . . . cord-010092-uftc8inx 3254 1 Further further JJ cord-010092-uftc8inx 3254 2 steps step NNS cord-010092-uftc8inx 3254 3 must must MD cord-010092-uftc8inx 3254 4 address address VB cord-010092-uftc8inx 3254 5 the the DT cord-010092-uftc8inx 3254 6 precise precise JJ cord-010092-uftc8inx 3254 7 methods method NNS cord-010092-uftc8inx 3254 8 of of IN cord-010092-uftc8inx 3254 9 data datum NNS cord-010092-uftc8inx 3254 10 exchange exchange NN cord-010092-uftc8inx 3254 11 , , , cord-010092-uftc8inx 3254 12 identification identification NN cord-010092-uftc8inx 3254 13 of of IN cord-010092-uftc8inx 3254 14 responsible responsible JJ cord-010092-uftc8inx 3254 15 entities entity NNS cord-010092-uftc8inx 3254 16 for for IN cord-010092-uftc8inx 3254 17 maintenance maintenance NN cord-010092-uftc8inx 3254 18 and and CC cord-010092-uftc8inx 3254 19 further further JJ cord-010092-uftc8inx 3254 20 development development NN cord-010092-uftc8inx 3254 21 , , , cord-010092-uftc8inx 3254 22 and and CC cord-010092-uftc8inx 3254 23 engagement engagement NN cord-010092-uftc8inx 3254 24 of of IN cord-010092-uftc8inx 3254 25 computer computer NN cord-010092-uftc8inx 3254 26 system system NN cord-010092-uftc8inx 3254 27 developers developer NNS cord-010092-uftc8inx 3254 28 . . . cord-010092-uftc8inx 3255 1 Red red JJ cord-010092-uftc8inx 3255 2 blood blood NN cord-010092-uftc8inx 3255 3 cell cell NN cord-010092-uftc8inx 3255 4 ( ( -LRB- cord-010092-uftc8inx 3255 5 RBC RBC NNP cord-010092-uftc8inx 3255 6 ) ) -RRB- cord-010092-uftc8inx 3255 7 alloantibodies alloantibody NNS cord-010092-uftc8inx 3255 8 develop develop VBP cord-010092-uftc8inx 3255 9 in in IN cord-010092-uftc8inx 3255 10 a a DT cord-010092-uftc8inx 3255 11 subset subset NN cord-010092-uftc8inx 3255 12 of of IN cord-010092-uftc8inx 3255 13 individuals individual NNS cord-010092-uftc8inx 3255 14 following follow VBG cord-010092-uftc8inx 3255 15 exposure exposure NN cord-010092-uftc8inx 3255 16 to to IN cord-010092-uftc8inx 3255 17 non non JJ cord-010092-uftc8inx 3255 18 - - JJ cord-010092-uftc8inx 3255 19 self self JJ cord-010092-uftc8inx 3255 20 RBCs rbc NNS cord-010092-uftc8inx 3255 21 through through IN cord-010092-uftc8inx 3255 22 transfusion transfusion NN cord-010092-uftc8inx 3255 23 , , , cord-010092-uftc8inx 3255 24 pregnancy pregnancy NN cord-010092-uftc8inx 3255 25 , , , cord-010092-uftc8inx 3255 26 or or CC cord-010092-uftc8inx 3255 27 other other JJ cord-010092-uftc8inx 3255 28 activities activity NNS cord-010092-uftc8inx 3255 29 ; ; : cord-010092-uftc8inx 3255 30 these these DT cord-010092-uftc8inx 3255 31 antibodies antibody NNS cord-010092-uftc8inx 3255 32 can can MD cord-010092-uftc8inx 3255 33 lead lead VB cord-010092-uftc8inx 3255 34 to to IN cord-010092-uftc8inx 3255 35 difficulty difficulty NN cord-010092-uftc8inx 3255 36 locating locate VBG cord-010092-uftc8inx 3255 37 compatible compatible JJ cord-010092-uftc8inx 3255 38 RBCs rbc NNS cord-010092-uftc8inx 3255 39 , , , cord-010092-uftc8inx 3255 40 acute acute JJ cord-010092-uftc8inx 3255 41 or or CC cord-010092-uftc8inx 3255 42 delayed delayed JJ cord-010092-uftc8inx 3255 43 hemolytic hemolytic JJ cord-010092-uftc8inx 3255 44 transfusion transfusion NN cord-010092-uftc8inx 3255 45 reactions reaction NNS cord-010092-uftc8inx 3255 46 , , , cord-010092-uftc8inx 3255 47 or or CC cord-010092-uftc8inx 3255 48 hemolytic hemolytic JJ cord-010092-uftc8inx 3255 49 disease disease NN cord-010092-uftc8inx 3255 50 of of IN cord-010092-uftc8inx 3255 51 the the DT cord-010092-uftc8inx 3255 52 newborn newborn NN cord-010092-uftc8inx 3255 53 . . . cord-010092-uftc8inx 3256 1 Alloimmunization Alloimmunization NNP cord-010092-uftc8inx 3256 2 is be VBZ cord-010092-uftc8inx 3256 3 underestimated underestimate VBN cord-010092-uftc8inx 3256 4 due due JJ cord-010092-uftc8inx 3256 5 in in IN cord-010092-uftc8inx 3256 6 part part NN cord-010092-uftc8inx 3256 7 to to IN cord-010092-uftc8inx 3256 8 antibody antibody NN cord-010092-uftc8inx 3256 9 evanescence evanescence NNP cord-010092-uftc8inx 3256 10 , , , cord-010092-uftc8inx 3256 11 the the DT cord-010092-uftc8inx 3256 12 random random JJ cord-010092-uftc8inx 3256 13 nature nature NN cord-010092-uftc8inx 3256 14 of of IN cord-010092-uftc8inx 3256 15 posttransfusion posttransfusion NN cord-010092-uftc8inx 3256 16 antibody antibody NN cord-010092-uftc8inx 3256 17 screens screen NNS cord-010092-uftc8inx 3256 18 , , , cord-010092-uftc8inx 3256 19 fragmented fragmented JJ cord-010092-uftc8inx 3256 20 medical medical JJ cord-010092-uftc8inx 3256 21 care care NN cord-010092-uftc8inx 3256 22 , , , cord-010092-uftc8inx 3256 23 and and CC cord-010092-uftc8inx 3256 24 the the DT cord-010092-uftc8inx 3256 25 lack lack NN cord-010092-uftc8inx 3256 26 of of IN cord-010092-uftc8inx 3256 27 widespread widespread JJ cord-010092-uftc8inx 3256 28 antibody antibody NN cord-010092-uftc8inx 3256 29 registries registry NNS cord-010092-uftc8inx 3256 30 . . . cord-010092-uftc8inx 3257 1 Factors factor NNS cord-010092-uftc8inx 3257 2 that that WDT cord-010092-uftc8inx 3257 3 influence influence NN cord-010092-uftc8inx 3257 4 who who WP cord-010092-uftc8inx 3257 5 will will MD cord-010092-uftc8inx 3257 6 develop develop VB cord-010092-uftc8inx 3257 7 detectable detectable JJ cord-010092-uftc8inx 3257 8 alloantibodies alloantibody NNS cord-010092-uftc8inx 3257 9 are be VBP cord-010092-uftc8inx 3257 10 not not RB cord-010092-uftc8inx 3257 11 well well RB cord-010092-uftc8inx 3257 12 understood understand VBN cord-010092-uftc8inx 3257 13 . . . cord-010092-uftc8inx 3258 1 Transfusion transfusion NN cord-010092-uftc8inx 3258 2 burden burden NN cord-010092-uftc8inx 3258 3 is be VBZ cord-010092-uftc8inx 3258 4 one one CD cord-010092-uftc8inx 3258 5 risk risk NN cord-010092-uftc8inx 3258 6 factor factor NN cord-010092-uftc8inx 3258 7 for for IN cord-010092-uftc8inx 3258 8 alloimmunization alloimmunization NN cord-010092-uftc8inx 3258 9 , , , cord-010092-uftc8inx 3258 10 though though IN cord-010092-uftc8inx 3258 11 many many JJ cord-010092-uftc8inx 3258 12 highly highly RB cord-010092-uftc8inx 3258 13 transfused transfuse VBN cord-010092-uftc8inx 3258 14 individuals individual NNS cord-010092-uftc8inx 3258 15 never never RB cord-010092-uftc8inx 3258 16 form form VB cord-010092-uftc8inx 3258 17 alloantibodies alloantibody NNS cord-010092-uftc8inx 3258 18 despite despite IN cord-010092-uftc8inx 3258 19 exposure exposure NN cord-010092-uftc8inx 3258 20 to to IN cord-010092-uftc8inx 3258 21 many many JJ cord-010092-uftc8inx 3258 22 RBC RBC NNP cord-010092-uftc8inx 3258 23 units unit NNS cord-010092-uftc8inx 3258 24 ( ( -LRB- cord-010092-uftc8inx 3258 25 and and CC cord-010092-uftc8inx 3258 26 many many JJ cord-010092-uftc8inx 3258 27 non non JJ cord-010092-uftc8inx 3258 28 - - JJ cord-010092-uftc8inx 3258 29 self self JJ cord-010092-uftc8inx 3258 30 ABO ABO NNP cord-010092-uftc8inx 3258 31 blood blood NN cord-010092-uftc8inx 3258 32 group group NN cord-010092-uftc8inx 3258 33 antigens antigen NNS cord-010092-uftc8inx 3258 34 ) ) -RRB- cord-010092-uftc8inx 3258 35 . . . cord-010092-uftc8inx 3259 1 Individuals individual NNS cord-010092-uftc8inx 3259 2 with with IN cord-010092-uftc8inx 3259 3 sickle sickle NN cord-010092-uftc8inx 3259 4 cell cell NN cord-010092-uftc8inx 3259 5 disease disease NN cord-010092-uftc8inx 3259 6 ( ( -LRB- cord-010092-uftc8inx 3259 7 SCD SCD NNP cord-010092-uftc8inx 3259 8 ) ) -RRB- cord-010092-uftc8inx 3259 9 and and CC cord-010092-uftc8inx 3259 10 myelodysplastic myelodysplastic JJ cord-010092-uftc8inx 3259 11 syndrome syndrome NN cord-010092-uftc8inx 3259 12 ( ( -LRB- cord-010092-uftc8inx 3259 13 MDS MDS NNP cord-010092-uftc8inx 3259 14 ) ) -RRB- cord-010092-uftc8inx 3259 15 are be VBP cord-010092-uftc8inx 3259 16 more more RBR cord-010092-uftc8inx 3259 17 likely likely JJ cord-010092-uftc8inx 3259 18 to to TO cord-010092-uftc8inx 3259 19 form form VB cord-010092-uftc8inx 3259 20 RBC RBC NNP cord-010092-uftc8inx 3259 21 alloantibodies alloantibody NNS cord-010092-uftc8inx 3259 22 than than IN cord-010092-uftc8inx 3259 23 most most JJS cord-010092-uftc8inx 3259 24 other other JJ cord-010092-uftc8inx 3259 25 patient patient JJ cord-010092-uftc8inx 3259 26 populations population NNS cord-010092-uftc8inx 3259 27 . . . cord-010092-uftc8inx 3260 1 Individuals individual NNS cord-010092-uftc8inx 3260 2 with with IN cord-010092-uftc8inx 3260 3 rheumatologic rheumatologic NNP cord-010092-uftc8inx 3260 4 and and CC cord-010092-uftc8inx 3260 5 other other JJ cord-010092-uftc8inx 3260 6 forms form NNS cord-010092-uftc8inx 3260 7 of of IN cord-010092-uftc8inx 3260 8 autoimmunity autoimmunity NN cord-010092-uftc8inx 3260 9 , , , cord-010092-uftc8inx 3260 10 though though IN cord-010092-uftc8inx 3260 11 not not RB cord-010092-uftc8inx 3260 12 chronically chronically RB cord-010092-uftc8inx 3260 13 transfused transfuse VBN cord-010092-uftc8inx 3260 14 , , , cord-010092-uftc8inx 3260 15 are be VBP cord-010092-uftc8inx 3260 16 also also RB cord-010092-uftc8inx 3260 17 at at IN cord-010092-uftc8inx 3260 18 higher high JJR cord-010092-uftc8inx 3260 19 than than IN cord-010092-uftc8inx 3260 20 average average JJ cord-010092-uftc8inx 3260 21 risk risk NN cord-010092-uftc8inx 3260 22 of of IN cord-010092-uftc8inx 3260 23 forming form VBG cord-010092-uftc8inx 3260 24 RBC RBC NNP cord-010092-uftc8inx 3260 25 alloantibodies alloantibody NNS cord-010092-uftc8inx 3260 26 . . . cord-010092-uftc8inx 3261 1 Inflammation inflammation NN cord-010092-uftc8inx 3261 2 , , , cord-010092-uftc8inx 3261 3 in in IN cord-010092-uftc8inx 3261 4 a a DT cord-010092-uftc8inx 3261 5 broad broad JJ cord-010092-uftc8inx 3261 6 sense sense NN cord-010092-uftc8inx 3261 7 , , , cord-010092-uftc8inx 3261 8 is be VBZ cord-010092-uftc8inx 3261 9 one one CD cord-010092-uftc8inx 3261 10 common common JJ cord-010092-uftc8inx 3261 11 thread thread NN cord-010092-uftc8inx 3261 12 among among IN cord-010092-uftc8inx 3261 13 these these DT cord-010092-uftc8inx 3261 14 diagnoses diagnosis NNS cord-010092-uftc8inx 3261 15 associated associate VBN cord-010092-uftc8inx 3261 16 with with IN cord-010092-uftc8inx 3261 17 high high JJ cord-010092-uftc8inx 3261 18 prevalence prevalence NN cord-010092-uftc8inx 3261 19 rates rate NNS cord-010092-uftc8inx 3261 20 of of IN cord-010092-uftc8inx 3261 21 RBC RBC NNP cord-010092-uftc8inx 3261 22 alloimmunization alloimmunization NN cord-010092-uftc8inx 3261 23 . . . cord-010092-uftc8inx 3262 1 Reductionist reductionist JJ cord-010092-uftc8inx 3262 2 murine murine JJ cord-010092-uftc8inx 3262 3 models model NNS cord-010092-uftc8inx 3262 4 support support VBP cord-010092-uftc8inx 3262 5 some some DT cord-010092-uftc8inx 3262 6 types type NNS cord-010092-uftc8inx 3262 7 of of IN cord-010092-uftc8inx 3262 8 inflammation inflammation NN cord-010092-uftc8inx 3262 9 ( ( -LRB- cord-010092-uftc8inx 3262 10 including include VBG cord-010092-uftc8inx 3262 11 viral viral JJ cord-010092-uftc8inx 3262 12 - - HYPH cord-010092-uftc8inx 3262 13 like like JJ cord-010092-uftc8inx 3262 14 stimuli stimulus NNS cord-010092-uftc8inx 3262 15 ) ) -RRB- cord-010092-uftc8inx 3262 16 around around IN cord-010092-uftc8inx 3262 17 the the DT cord-010092-uftc8inx 3262 18 time time NN cord-010092-uftc8inx 3262 19 of of IN cord-010092-uftc8inx 3262 20 RBC RBC NNP cord-010092-uftc8inx 3262 21 exposure exposure NN cord-010092-uftc8inx 3262 22 as as IN cord-010092-uftc8inx 3262 23 being be VBG cord-010092-uftc8inx 3262 24 associated associate VBN cord-010092-uftc8inx 3262 25 with with IN cord-010092-uftc8inx 3262 26 an an DT cord-010092-uftc8inx 3262 27 increased increase VBN cord-010092-uftc8inx 3262 28 likelihood likelihood NN cord-010092-uftc8inx 3262 29 of of IN cord-010092-uftc8inx 3262 30 alloantibody alloantibody NN cord-010092-uftc8inx 3262 31 formation formation NN cord-010092-uftc8inx 3262 32 . . . cord-010092-uftc8inx 3263 1 Strategies strategy NNS cord-010092-uftc8inx 3263 2 other other JJ cord-010092-uftc8inx 3263 3 than than IN cord-010092-uftc8inx 3263 4 transfusion transfusion NN cord-010092-uftc8inx 3263 5 avoidance avoidance NN cord-010092-uftc8inx 3263 6 or or CC cord-010092-uftc8inx 3263 7 extended extended JJ cord-010092-uftc8inx 3263 8 antigen antigen NN cord-010092-uftc8inx 3263 9 matching matching NN cord-010092-uftc8inx 3263 10 beyond beyond IN cord-010092-uftc8inx 3263 11 ABO/ ABO/ NNP cord-010092-uftc8inx 3263 12 Rh Rh NNP cord-010092-uftc8inx 3263 13 would would MD cord-010092-uftc8inx 3263 14 be be VB cord-010092-uftc8inx 3263 15 beneficial beneficial JJ cord-010092-uftc8inx 3263 16 to to TO cord-010092-uftc8inx 3263 17 prevent prevent VB cord-010092-uftc8inx 3263 18 new new JJ cord-010092-uftc8inx 3263 19 RBC RBC NNP cord-010092-uftc8inx 3263 20 alloantibody alloantibody NN cord-010092-uftc8inx 3263 21 formation formation NN cord-010092-uftc8inx 3263 22 , , , cord-010092-uftc8inx 3263 23 especially especially RB cord-010092-uftc8inx 3263 24 in in IN cord-010092-uftc8inx 3263 25 patients patient NNS cord-010092-uftc8inx 3263 26 at at IN cord-010092-uftc8inx 3263 27 highest high JJS cord-010092-uftc8inx 3263 28 risk risk NN cord-010092-uftc8inx 3263 29 . . . cord-010092-uftc8inx 3264 1 Background background NN cord-010092-uftc8inx 3264 2 : : : cord-010092-uftc8inx 3265 1 The the DT cord-010092-uftc8inx 3265 2 unique unique JJ cord-010092-uftc8inx 3265 3 genetic genetic JJ cord-010092-uftc8inx 3265 4 makeup makeup NN cord-010092-uftc8inx 3265 5 of of IN cord-010092-uftc8inx 3265 6 the the DT cord-010092-uftc8inx 3265 7 Omani omani JJ cord-010092-uftc8inx 3265 8 population population NN cord-010092-uftc8inx 3265 9 makes make VBZ cord-010092-uftc8inx 3265 10 them -PRON- PRP cord-010092-uftc8inx 3265 11 rich rich JJ cord-010092-uftc8inx 3265 12 in in IN cord-010092-uftc8inx 3265 13 the the DT cord-010092-uftc8inx 3265 14 genetic genetic JJ cord-010092-uftc8inx 3265 15 blood blood NN cord-010092-uftc8inx 3265 16 disorder disorder NN cord-010092-uftc8inx 3265 17 . . . cord-010092-uftc8inx 3266 1 45 45 CD cord-010092-uftc8inx 3266 2 % % NN cord-010092-uftc8inx 3266 3 of of IN cord-010092-uftc8inx 3266 4 Omani omani JJ cord-010092-uftc8inx 3266 5 populations population NNS cord-010092-uftc8inx 3266 6 are be VBP cord-010092-uftc8inx 3267 1 Àa Àa NNP cord-010092-uftc8inx 3267 2 / / , cord-010092-uftc8inx 3267 3 Àa Àa NNP cord-010092-uftc8inx 3267 4 gene gene NN cord-010092-uftc8inx 3267 5 carriers carrier NNS cord-010092-uftc8inx 3267 6 , , , cord-010092-uftc8inx 3267 7 44 44 CD cord-010092-uftc8inx 3267 8 % % NN cord-010092-uftc8inx 3267 9 Àa Àa NNP cord-010092-uftc8inx 3267 10 / / SYM cord-010092-uftc8inx 3267 11 aa aa NNP cord-010092-uftc8inx 3267 12 , , , cord-010092-uftc8inx 3267 13 and and CC cord-010092-uftc8inx 3267 14 11 11 CD cord-010092-uftc8inx 3267 15 % % NN cord-010092-uftc8inx 3267 16 of of IN cord-010092-uftc8inx 3267 17 the the DT cord-010092-uftc8inx 3267 18 population population NN cord-010092-uftc8inx 3267 19 are be VBP cord-010092-uftc8inx 3267 20 aa aa NNP cord-010092-uftc8inx 3267 21 / / SYM cord-010092-uftc8inx 3267 22 aa aa NNP cord-010092-uftc8inx 3267 23 . . . cord-010092-uftc8inx 3268 1 Around around IN cord-010092-uftc8inx 3268 2 10 10 CD cord-010092-uftc8inx 3268 3 % % NN cord-010092-uftc8inx 3268 4 of of IN cord-010092-uftc8inx 3268 5 Omani omani JJ cord-010092-uftc8inx 3268 6 nationals national NNS cord-010092-uftc8inx 3268 7 carry carry VBP cord-010092-uftc8inx 3268 8 the the DT cord-010092-uftc8inx 3268 9 gene gene NN cord-010092-uftc8inx 3268 10 for for IN cord-010092-uftc8inx 3268 11 HbS HbS NNP cord-010092-uftc8inx 3268 12 , , , cord-010092-uftc8inx 3268 13 and and CC cord-010092-uftc8inx 3268 14 2 2 CD cord-010092-uftc8inx 3268 15 -3 -3 CD cord-010092-uftc8inx 3268 16 % % NN cord-010092-uftc8inx 3268 17 carry carry VBP cord-010092-uftc8inx 3268 18 the the DT cord-010092-uftc8inx 3268 19 gene gene NN cord-010092-uftc8inx 3268 20 for for IN cord-010092-uftc8inx 3268 21 b b NN cord-010092-uftc8inx 3268 22 - - HYPH cord-010092-uftc8inx 3268 23 thalassaemia thalassaemia NN cord-010092-uftc8inx 3268 24 . . . cord-010092-uftc8inx 3269 1 Recent recent JJ cord-010092-uftc8inx 3269 2 statistics statistic NNS cord-010092-uftc8inx 3269 3 show show VBP cord-010092-uftc8inx 3269 4 that that IN cord-010092-uftc8inx 3269 5 there there EX cord-010092-uftc8inx 3269 6 are be VBP cord-010092-uftc8inx 3269 7 around around RB cord-010092-uftc8inx 3269 8 400 400 CD cord-010092-uftc8inx 3269 9 patients patient NNS cord-010092-uftc8inx 3269 10 with with IN cord-010092-uftc8inx 3269 11 thalassaemia thalassaemia NN cord-010092-uftc8inx 3269 12 major major NN cord-010092-uftc8inx 3269 13 and and CC cord-010092-uftc8inx 3269 14 3000 3000 CD cord-010092-uftc8inx 3269 15 with with IN cord-010092-uftc8inx 3269 16 SCD SCD NNP cord-010092-uftc8inx 3269 17 in in IN cord-010092-uftc8inx 3269 18 Oman Oman NNP cord-010092-uftc8inx 3269 19 . . . cord-010092-uftc8inx 3270 1 The the DT cord-010092-uftc8inx 3270 2 other other JJ cord-010092-uftc8inx 3270 3 RBC RBC NNP cord-010092-uftc8inx 3270 4 abnormality abnormality NN cord-010092-uftc8inx 3270 5 that that WDT cord-010092-uftc8inx 3270 6 is be VBZ cord-010092-uftc8inx 3270 7 common common JJ cord-010092-uftc8inx 3270 8 in in IN cord-010092-uftc8inx 3270 9 Oman Oman NNP cord-010092-uftc8inx 3270 10 is be VBZ cord-010092-uftc8inx 3270 11 G6PD G6PD NNP cord-010092-uftc8inx 3270 12 deficiency deficiency NN cord-010092-uftc8inx 3270 13 which which WDT cord-010092-uftc8inx 3270 14 is be VBZ cord-010092-uftc8inx 3270 15 found find VBN cord-010092-uftc8inx 3270 16 in in IN cord-010092-uftc8inx 3270 17 28 28 CD cord-010092-uftc8inx 3270 18 % % NN cord-010092-uftc8inx 3270 19 of of IN cord-010092-uftc8inx 3270 20 males male NNS cord-010092-uftc8inx 3270 21 and and CC cord-010092-uftc8inx 3270 22 12 12 CD cord-010092-uftc8inx 3270 23 % % NN cord-010092-uftc8inx 3270 24 of of IN cord-010092-uftc8inx 3270 25 females female NNS cord-010092-uftc8inx 3270 26 . . . cord-010092-uftc8inx 3271 1 Omanis Omanis NNP cord-010092-uftc8inx 3271 2 are be VBP cord-010092-uftc8inx 3271 3 known know VBN cord-010092-uftc8inx 3271 4 to to TO cord-010092-uftc8inx 3271 5 have have VB cord-010092-uftc8inx 3271 6 the the DT cord-010092-uftc8inx 3271 7 highest high JJS cord-010092-uftc8inx 3271 8 frequency frequency NN cord-010092-uftc8inx 3271 9 of of IN cord-010092-uftc8inx 3271 10 a a DT cord-010092-uftc8inx 3271 11 thalassaemia thalassaemia NN cord-010092-uftc8inx 3271 12 and and CC cord-010092-uftc8inx 3271 13 G6PD G6PD NNP cord-010092-uftc8inx 3271 14 reported report VBD cord-010092-uftc8inx 3271 15 so so RB cord-010092-uftc8inx 3271 16 far far RB cord-010092-uftc8inx 3271 17 in in IN cord-010092-uftc8inx 3271 18 any any DT cord-010092-uftc8inx 3271 19 race race NN cord-010092-uftc8inx 3271 20 . . . cord-010092-uftc8inx 3272 1 Although although IN cord-010092-uftc8inx 3272 2 blood blood NN cord-010092-uftc8inx 3272 3 transfusion transfusion NN cord-010092-uftc8inx 3272 4 is be VBZ cord-010092-uftc8inx 3272 5 one one CD cord-010092-uftc8inx 3272 6 of of IN cord-010092-uftc8inx 3272 7 the the DT cord-010092-uftc8inx 3272 8 supporting support VBG cord-010092-uftc8inx 3272 9 treatments treatment NNS cord-010092-uftc8inx 3272 10 of of IN cord-010092-uftc8inx 3272 11 SCD SCD NNP cord-010092-uftc8inx 3272 12 , , , cord-010092-uftc8inx 3272 13 it -PRON- PRP cord-010092-uftc8inx 3272 14 can can MD cord-010092-uftc8inx 3272 15 cause cause VB cord-010092-uftc8inx 3272 16 some some DT cord-010092-uftc8inx 3272 17 serious serious JJ cord-010092-uftc8inx 3272 18 complications complication NNS cord-010092-uftc8inx 3272 19 for for IN cord-010092-uftc8inx 3272 20 the the DT cord-010092-uftc8inx 3272 21 patients patient NNS cord-010092-uftc8inx 3272 22 . . . cord-010092-uftc8inx 3273 1 Alloimmunization Alloimmunization NNP cord-010092-uftc8inx 3273 2 of of IN cord-010092-uftc8inx 3273 3 red red JJ cord-010092-uftc8inx 3273 4 blood blood NN cord-010092-uftc8inx 3273 5 cells cell NNS cord-010092-uftc8inx 3273 6 is be VBZ cord-010092-uftc8inx 3273 7 one one CD cord-010092-uftc8inx 3273 8 of of IN cord-010092-uftc8inx 3273 9 the the DT cord-010092-uftc8inx 3273 10 consequences consequence NNS cord-010092-uftc8inx 3273 11 of of IN cord-010092-uftc8inx 3273 12 blood blood NN cord-010092-uftc8inx 3273 13 transfusion transfusion NN cord-010092-uftc8inx 3273 14 . . . cord-010092-uftc8inx 3274 1 Alloimmunisation Alloimmunisation NNP cord-010092-uftc8inx 3274 2 of of IN cord-010092-uftc8inx 3274 3 the the DT cord-010092-uftc8inx 3274 4 RBCS rbc NNS cord-010092-uftc8inx 3274 5 can can MD cord-010092-uftc8inx 3274 6 cause cause VB cord-010092-uftc8inx 3274 7 haemolytic haemolytic JJ cord-010092-uftc8inx 3274 8 transfusion transfusion NN cord-010092-uftc8inx 3274 9 reactions reaction NNS cord-010092-uftc8inx 3274 10 and and CC cord-010092-uftc8inx 3274 11 may may MD cord-010092-uftc8inx 3274 12 trigger trigger VB cord-010092-uftc8inx 3274 13 hyperhaemolysis hyperhaemolysis NNP cord-010092-uftc8inx 3274 14 , , , cord-010092-uftc8inx 3274 15 in in IN cord-010092-uftc8inx 3274 16 which which WDT cord-010092-uftc8inx 3274 17 transfused transfuse VBN cord-010092-uftc8inx 3274 18 and and CC cord-010092-uftc8inx 3274 19 patient patient JJ cord-010092-uftc8inx 3274 20 's 's POS cord-010092-uftc8inx 3274 21 own own JJ cord-010092-uftc8inx 3274 22 RBCs rbc NNS cord-010092-uftc8inx 3274 23 are be VBP cord-010092-uftc8inx 3274 24 destroyed destroy VBN cord-010092-uftc8inx 3274 25 . . . cord-010092-uftc8inx 3275 1 Alloantibodies alloantibody NNS cord-010092-uftc8inx 3275 2 can can MD cord-010092-uftc8inx 3275 3 cause cause VB cord-010092-uftc8inx 3275 4 delay delay NN cord-010092-uftc8inx 3275 5 in in IN cord-010092-uftc8inx 3275 6 the the DT cord-010092-uftc8inx 3275 7 process process NN cord-010092-uftc8inx 3275 8 of of IN cord-010092-uftc8inx 3275 9 transfusion transfusion NN cord-010092-uftc8inx 3275 10 , , , cord-010092-uftc8inx 3275 11 it -PRON- PRP cord-010092-uftc8inx 3275 12 can can MD cord-010092-uftc8inx 3275 13 be be VB cord-010092-uftc8inx 3275 14 costly costly JJ cord-010092-uftc8inx 3275 15 and and CC cord-010092-uftc8inx 3275 16 time time NN cord-010092-uftc8inx 3275 17 consuming consume VBG cord-010092-uftc8inx 3275 18 . . . cord-010092-uftc8inx 3276 1 High high JJ cord-010092-uftc8inx 3276 2 number number NN cord-010092-uftc8inx 3276 3 of of IN cord-010092-uftc8inx 3276 4 patients patient NNS cord-010092-uftc8inx 3276 5 developing develop VBG cord-010092-uftc8inx 3276 6 alloantibodies alloantibody NNS cord-010092-uftc8inx 3276 7 may may MD cord-010092-uftc8inx 3276 8 indicate indicate VB cord-010092-uftc8inx 3276 9 a a DT cord-010092-uftc8inx 3276 10 major major JJ cord-010092-uftc8inx 3276 11 difference difference NN cord-010092-uftc8inx 3276 12 in in IN cord-010092-uftc8inx 3276 13 the the DT cord-010092-uftc8inx 3276 14 patient patient NN cord-010092-uftc8inx 3276 15 and and CC cord-010092-uftc8inx 3276 16 donor donor NN cord-010092-uftc8inx 3276 17 population population NN cord-010092-uftc8inx 3276 18 . . . cord-010092-uftc8inx 3277 1 It -PRON- PRP cord-010092-uftc8inx 3277 2 may may MD cord-010092-uftc8inx 3277 3 also also RB cord-010092-uftc8inx 3277 4 indicate indicate VB cord-010092-uftc8inx 3277 5 lack lack NN cord-010092-uftc8inx 3277 6 of of IN cord-010092-uftc8inx 3277 7 a a DT cord-010092-uftc8inx 3277 8 controlled control VBN cord-010092-uftc8inx 3277 9 , , , cord-010092-uftc8inx 3277 10 generalised generalised JJ cord-010092-uftc8inx 3277 11 sickle sickle NN cord-010092-uftc8inx 3277 12 patients patient NNS cord-010092-uftc8inx 3277 13 management management NN cord-010092-uftc8inx 3277 14 policy policy NN cord-010092-uftc8inx 3277 15 . . . cord-010092-uftc8inx 3278 1 In in IN cord-010092-uftc8inx 3278 2 Oman Oman NNP cord-010092-uftc8inx 3278 3 the the DT cord-010092-uftc8inx 3278 4 decision decision NN cord-010092-uftc8inx 3278 5 of of IN cord-010092-uftc8inx 3278 6 transfusing transfuse VBG cord-010092-uftc8inx 3278 7 SCD SCD NNP cord-010092-uftc8inx 3278 8 patient patient NN cord-010092-uftc8inx 3278 9 is be VBZ cord-010092-uftc8inx 3278 10 left leave VBN cord-010092-uftc8inx 3278 11 to to IN cord-010092-uftc8inx 3278 12 physicians physician NNS cord-010092-uftc8inx 3278 13 attending attend VBG cord-010092-uftc8inx 3278 14 the the DT cord-010092-uftc8inx 3278 15 patient patient NN cord-010092-uftc8inx 3278 16 . . . cord-010092-uftc8inx 3279 1 Aims aim VBZ cord-010092-uftc8inx 3279 2 : : : cord-010092-uftc8inx 3280 1 This this DT cord-010092-uftc8inx 3280 2 study study NN cord-010092-uftc8inx 3280 3 is be VBZ cord-010092-uftc8inx 3280 4 aimed aim VBN cord-010092-uftc8inx 3280 5 to to TO cord-010092-uftc8inx 3280 6 highlight highlight VB cord-010092-uftc8inx 3280 7 the the DT cord-010092-uftc8inx 3280 8 increasing increase VBG cord-010092-uftc8inx 3280 9 number number NN cord-010092-uftc8inx 3280 10 of of IN cord-010092-uftc8inx 3280 11 alloimmunised alloimmunise VBN cord-010092-uftc8inx 3280 12 sickle sickle NN cord-010092-uftc8inx 3280 13 cell cell NN cord-010092-uftc8inx 3280 14 patients patient NNS cord-010092-uftc8inx 3280 15 . . . cord-010092-uftc8inx 3281 1 In in IN cord-010092-uftc8inx 3281 2 the the DT cord-010092-uftc8inx 3281 3 Royal Royal NNP cord-010092-uftc8inx 3281 4 Hospital Hospital NNP cord-010092-uftc8inx 3281 5 we -PRON- PRP cord-010092-uftc8inx 3281 6 get get VBP cord-010092-uftc8inx 3281 7 40 40 CD cord-010092-uftc8inx 3281 8 new new JJ cord-010092-uftc8inx 3281 9 cases case NNS cord-010092-uftc8inx 3281 10 of of IN cord-010092-uftc8inx 3281 11 sickle sickle NN cord-010092-uftc8inx 3281 12 patient patient NN cord-010092-uftc8inx 3281 13 with with IN cord-010092-uftc8inx 3281 14 alloantibodies alloantibody NNS cord-010092-uftc8inx 3281 15 each each DT cord-010092-uftc8inx 3281 16 year year NN cord-010092-uftc8inx 3281 17 . . . cord-010092-uftc8inx 3282 1 The the DT cord-010092-uftc8inx 3282 2 acknowledgement acknowledgement NN cord-010092-uftc8inx 3282 3 of of IN cord-010092-uftc8inx 3282 4 these these DT cord-010092-uftc8inx 3282 5 cases case NNS cord-010092-uftc8inx 3282 6 may may MD cord-010092-uftc8inx 3282 7 help help VB cord-010092-uftc8inx 3282 8 in in IN cord-010092-uftc8inx 3282 9 is be VBZ cord-010092-uftc8inx 3282 10 assessing assess VBG cord-010092-uftc8inx 3282 11 the the DT cord-010092-uftc8inx 3282 12 current current JJ cord-010092-uftc8inx 3282 13 practice practice NN cord-010092-uftc8inx 3282 14 of of IN cord-010092-uftc8inx 3282 15 transfusing transfuse VBG cord-010092-uftc8inx 3282 16 SCD SCD NNP cord-010092-uftc8inx 3282 17 patients patient NNS cord-010092-uftc8inx 3282 18 , , , cord-010092-uftc8inx 3282 19 or or CC cord-010092-uftc8inx 3282 20 will will MD cord-010092-uftc8inx 3282 21 help help VB cord-010092-uftc8inx 3282 22 to to TO cord-010092-uftc8inx 3282 23 define define VB cord-010092-uftc8inx 3282 24 the the DT cord-010092-uftc8inx 3282 25 donor donor NN cord-010092-uftc8inx 3282 26 and and CC cord-010092-uftc8inx 3282 27 patient patient JJ cord-010092-uftc8inx 3282 28 population population NN cord-010092-uftc8inx 3282 29 difference difference NN cord-010092-uftc8inx 3282 30 . . . cord-010092-uftc8inx 3283 1 Methods method NNS cord-010092-uftc8inx 3283 2 : : : cord-010092-uftc8inx 3283 3 418 418 CD cord-010092-uftc8inx 3283 4 patients patient NNS cord-010092-uftc8inx 3283 5 were be VBD cord-010092-uftc8inx 3283 6 recruited recruit VBN cord-010092-uftc8inx 3283 7 in in IN cord-010092-uftc8inx 3283 8 the the DT cord-010092-uftc8inx 3283 9 Royal Royal NNP cord-010092-uftc8inx 3283 10 Hospital Hospital NNP cord-010092-uftc8inx 3283 11 for for IN cord-010092-uftc8inx 3283 12 this this DT cord-010092-uftc8inx 3283 13 study study NN cord-010092-uftc8inx 3283 14 . . . cord-010092-uftc8inx 3284 1 EDTA EDTA NNP cord-010092-uftc8inx 3284 2 blood blood NN cord-010092-uftc8inx 3284 3 samples sample NNS cord-010092-uftc8inx 3284 4 were be VBD cord-010092-uftc8inx 3284 5 taken take VBN cord-010092-uftc8inx 3284 6 for for IN cord-010092-uftc8inx 3284 7 antibody antibody NN cord-010092-uftc8inx 3284 8 screening screening NN cord-010092-uftc8inx 3284 9 test test NN cord-010092-uftc8inx 3284 10 and and CC cord-010092-uftc8inx 3284 11 in in IN cord-010092-uftc8inx 3284 12 the the DT cord-010092-uftc8inx 3284 13 positive positive JJ cord-010092-uftc8inx 3284 14 cases case NNS cord-010092-uftc8inx 3284 15 antibody antibody NN cord-010092-uftc8inx 3284 16 was be VBD cord-010092-uftc8inx 3284 17 identified identify VBN cord-010092-uftc8inx 3284 18 , , , cord-010092-uftc8inx 3284 19 all all DT cord-010092-uftc8inx 3284 20 tests test NNS cord-010092-uftc8inx 3284 21 done do VBN cord-010092-uftc8inx 3284 22 by by IN cord-010092-uftc8inx 3284 23 capture capture NN cord-010092-uftc8inx 3284 24 technique technique NN cord-010092-uftc8inx 3284 25 using use VBG cord-010092-uftc8inx 3284 26 Immucor Immucor NNP cord-010092-uftc8inx 3284 27 Neo Neo NNP cord-010092-uftc8inx 3284 28 machine machine NN cord-010092-uftc8inx 3284 29 . . . cord-010092-uftc8inx 3285 1 Results result NNS cord-010092-uftc8inx 3285 2 : : : cord-010092-uftc8inx 3286 1 Of of IN cord-010092-uftc8inx 3286 2 the the DT cord-010092-uftc8inx 3286 3 418 418 CD cord-010092-uftc8inx 3286 4 SCD SCD NNP cord-010092-uftc8inx 3286 5 patients patient NNS cord-010092-uftc8inx 3286 6 , , , cord-010092-uftc8inx 3286 7 49 49 CD cord-010092-uftc8inx 3286 8 % % NN cord-010092-uftc8inx 3286 9 of of IN cord-010092-uftc8inx 3286 10 the the DT cord-010092-uftc8inx 3286 11 patients patient NNS cord-010092-uftc8inx 3286 12 were be VBD cord-010092-uftc8inx 3286 13 male male JJ cord-010092-uftc8inx 3286 14 and and CC cord-010092-uftc8inx 3286 15 51 51 CD cord-010092-uftc8inx 3286 16 % % NN cord-010092-uftc8inx 3286 17 female female NN cord-010092-uftc8inx 3286 18 , , , cord-010092-uftc8inx 3286 19 mean mean JJ cord-010092-uftc8inx 3286 20 age age NN cord-010092-uftc8inx 3286 21 was be VBD cord-010092-uftc8inx 3286 22 17 17 CD cord-010092-uftc8inx 3286 23 years year NNS cord-010092-uftc8inx 3286 24 , , , cord-010092-uftc8inx 3286 25 in in IN cord-010092-uftc8inx 3286 26 the the DT cord-010092-uftc8inx 3286 27 range range NN cord-010092-uftc8inx 3286 28 of of IN cord-010092-uftc8inx 3286 29 1 1 CD cord-010092-uftc8inx 3286 30 - - SYM cord-010092-uftc8inx 3286 31 72 72 CD cord-010092-uftc8inx 3286 32 years year NNS cord-010092-uftc8inx 3286 33 . . . cord-010092-uftc8inx 3287 1 38 38 CD cord-010092-uftc8inx 3287 2 % % NN cord-010092-uftc8inx 3287 3 of of IN cord-010092-uftc8inx 3287 4 the the DT cord-010092-uftc8inx 3287 5 SCD SCD NNP cord-010092-uftc8inx 3287 6 cases case NNS cord-010092-uftc8inx 3287 7 were be VBD cord-010092-uftc8inx 3287 8 positive positive JJ cord-010092-uftc8inx 3287 9 for for IN cord-010092-uftc8inx 3287 10 the the DT cord-010092-uftc8inx 3287 11 alloantibodies alloantibody NNS cord-010092-uftc8inx 3287 12 , , , cord-010092-uftc8inx 3287 13 72 72 CD cord-010092-uftc8inx 3287 14 % % NN cord-010092-uftc8inx 3287 15 were be VBD cord-010092-uftc8inx 3287 16 Female female JJ cord-010092-uftc8inx 3287 17 and and CC cord-010092-uftc8inx 3287 18 28 28 CD cord-010092-uftc8inx 3287 19 % % NN cord-010092-uftc8inx 3287 20 were be VBD cord-010092-uftc8inx 3287 21 male male JJ cord-010092-uftc8inx 3287 22 , , , cord-010092-uftc8inx 3287 23 the the DT cord-010092-uftc8inx 3287 24 age age NN cord-010092-uftc8inx 3287 25 range range NN cord-010092-uftc8inx 3287 26 was be VBD cord-010092-uftc8inx 3287 27 from from IN cord-010092-uftc8inx 3287 28 6 6 CD cord-010092-uftc8inx 3287 29 - - SYM cord-010092-uftc8inx 3287 30 68 68 CD cord-010092-uftc8inx 3287 31 years year NNS cord-010092-uftc8inx 3287 32 . . . cord-010092-uftc8inx 3288 1 78 78 CD cord-010092-uftc8inx 3288 2 % % NN cord-010092-uftc8inx 3288 3 of of IN cord-010092-uftc8inx 3288 4 the the DT cord-010092-uftc8inx 3288 5 positive positive JJ cord-010092-uftc8inx 3288 6 were be VBD cord-010092-uftc8inx 3288 7 SCD SCD NNP cord-010092-uftc8inx 3288 8 , , , cord-010092-uftc8inx 3288 9 19 19 CD cord-010092-uftc8inx 3288 10 % % NN cord-010092-uftc8inx 3288 11 S s NN cord-010092-uftc8inx 3288 12 trait trait NN cord-010092-uftc8inx 3288 13 and and CC cord-010092-uftc8inx 3288 14 3 3 CD cord-010092-uftc8inx 3288 15 % % NN cord-010092-uftc8inx 3288 16 were be VBD cord-010092-uftc8inx 3288 17 S/ S/ NNP cord-010092-uftc8inx 3288 18 bthal bthal NNS cord-010092-uftc8inx 3288 19 . . . cord-010092-uftc8inx 3289 1 Most Most JJS cord-010092-uftc8inx 3289 2 of of IN cord-010092-uftc8inx 3289 3 the the DT cord-010092-uftc8inx 3289 4 patients patient NNS cord-010092-uftc8inx 3289 5 developed develop VBD cord-010092-uftc8inx 3289 6 one one CD cord-010092-uftc8inx 3289 7 antibody antibody NN cord-010092-uftc8inx 3289 8 , , , cord-010092-uftc8inx 3289 9 however however RB cord-010092-uftc8inx 3289 10 cases case NNS cord-010092-uftc8inx 3289 11 of of IN cord-010092-uftc8inx 3289 12 multiples multiple NNS cord-010092-uftc8inx 3289 13 antibodies antibody NNS cord-010092-uftc8inx 3289 14 were be VBD cord-010092-uftc8inx 3289 15 also also RB cord-010092-uftc8inx 3289 16 detected detect VBN cord-010092-uftc8inx 3289 17 . . . cord-010092-uftc8inx 3290 1 51 51 CD cord-010092-uftc8inx 3290 2 % % NN cord-010092-uftc8inx 3290 3 of of IN cord-010092-uftc8inx 3290 4 the the DT cord-010092-uftc8inx 3290 5 patients patient NNS cord-010092-uftc8inx 3290 6 were be VBD cord-010092-uftc8inx 3290 7 with with IN cord-010092-uftc8inx 3290 8 single single JJ cord-010092-uftc8inx 3290 9 alloantibody alloantibody NN cord-010092-uftc8inx 3290 10 , , , cord-010092-uftc8inx 3290 11 30 30 CD cord-010092-uftc8inx 3290 12 % % NN cord-010092-uftc8inx 3290 13 of of IN cord-010092-uftc8inx 3290 14 them -PRON- PRP cord-010092-uftc8inx 3290 15 with with IN cord-010092-uftc8inx 3290 16 two two CD cord-010092-uftc8inx 3290 17 antibodies antibody NNS cord-010092-uftc8inx 3290 18 , , , cord-010092-uftc8inx 3290 19 10 10 CD cord-010092-uftc8inx 3290 20 % % NN cord-010092-uftc8inx 3290 21 with with IN cord-010092-uftc8inx 3290 22 three three CD cord-010092-uftc8inx 3290 23 antibodies antibody NNS cord-010092-uftc8inx 3290 24 , , , cord-010092-uftc8inx 3290 25 7 7 CD cord-010092-uftc8inx 3290 26 % % NN cord-010092-uftc8inx 3290 27 with with IN cord-010092-uftc8inx 3290 28 four four CD cord-010092-uftc8inx 3290 29 antibodies antibody NNS cord-010092-uftc8inx 3290 30 and and CC cord-010092-uftc8inx 3290 31 2 2 CD cord-010092-uftc8inx 3290 32 % % NN cord-010092-uftc8inx 3290 33 with with IN cord-010092-uftc8inx 3290 34 five five CD cord-010092-uftc8inx 3290 35 antibodies antibody NNS cord-010092-uftc8inx 3290 36 . . . cord-010092-uftc8inx 3291 1 The the DT cord-010092-uftc8inx 3291 2 majority majority NN cord-010092-uftc8inx 3291 3 of of IN cord-010092-uftc8inx 3291 4 the the DT cord-010092-uftc8inx 3291 5 cases case NNS cord-010092-uftc8inx 3291 6 were be VBD cord-010092-uftc8inx 3291 7 IgG igg NN cord-010092-uftc8inx 3291 8 against against IN cord-010092-uftc8inx 3291 9 Rh Rh NNP cord-010092-uftc8inx 3291 10 antigens antigen NNS cord-010092-uftc8inx 3291 11 anti anti JJ cord-010092-uftc8inx 3291 12 - - NN cord-010092-uftc8inx 3291 13 E e JJ cord-010092-uftc8inx 3291 14 is be VBZ cord-010092-uftc8inx 3291 15 being be VBG cord-010092-uftc8inx 3291 16 the the DT cord-010092-uftc8inx 3291 17 majority majority NN cord-010092-uftc8inx 3291 18 23 23 CD cord-010092-uftc8inx 3291 19 % % NN cord-010092-uftc8inx 3291 20 , , , cord-010092-uftc8inx 3291 21 followed follow VBN cord-010092-uftc8inx 3291 22 by by IN cord-010092-uftc8inx 3291 23 anti anti JJ cord-010092-uftc8inx 3291 24 - - JJ cord-010092-uftc8inx 3291 25 D d JJ cord-010092-uftc8inx 3291 26 13 13 CD cord-010092-uftc8inx 3291 27 % % NN cord-010092-uftc8inx 3291 28 , , , cord-010092-uftc8inx 3291 29 anti anti JJ cord-010092-uftc8inx 3291 30 - - JJ cord-010092-uftc8inx 3291 31 K K NNP cord-010092-uftc8inx 3291 32 17 17 CD cord-010092-uftc8inx 3291 33 % % NN cord-010092-uftc8inx 3291 34 , , , cord-010092-uftc8inx 3291 35 anti anti JJ cord-010092-uftc8inx 3291 36 - - NNP cord-010092-uftc8inx 3291 37 C C NNP cord-010092-uftc8inx 3291 38 14 14 CD cord-010092-uftc8inx 3291 39 % % NN cord-010092-uftc8inx 3291 40 , , , cord-010092-uftc8inx 3291 41 anti anti JJ cord-010092-uftc8inx 3291 42 - - NN cord-010092-uftc8inx 3291 43 c c JJ cord-010092-uftc8inx 3291 44 8 8 CD cord-010092-uftc8inx 3291 45 % % NN cord-010092-uftc8inx 3291 46 , , , cord-010092-uftc8inx 3291 47 anti anti NNP cord-010092-uftc8inx 3291 48 - - NNP cord-010092-uftc8inx 3291 49 Jk Jk NNP cord-010092-uftc8inx 3291 50 a a DT cord-010092-uftc8inx 3291 51 5 5 CD cord-010092-uftc8inx 3291 52 % % NN cord-010092-uftc8inx 3291 53 , , , cord-010092-uftc8inx 3291 54 anti anti JJ cord-010092-uftc8inx 3291 55 - - NNP cord-010092-uftc8inx 3291 56 Jk Jk NNP cord-010092-uftc8inx 3291 57 b b NN cord-010092-uftc8inx 3291 58 5 5 CD cord-010092-uftc8inx 3291 59 % % NN cord-010092-uftc8inx 3291 60 , , , cord-010092-uftc8inx 3291 61 anti anti JJ cord-010092-uftc8inx 3291 62 - - JJ cord-010092-uftc8inx 3291 63 Fy Fy NNP cord-010092-uftc8inx 3291 64 a a DT cord-010092-uftc8inx 3291 65 5 5 CD cord-010092-uftc8inx 3291 66 % % NN cord-010092-uftc8inx 3291 67 , , , cord-010092-uftc8inx 3291 68 anti anti JJ cord-010092-uftc8inx 3291 69 - - NN cord-010092-uftc8inx 3291 70 e e NN cord-010092-uftc8inx 3291 71 3 3 CD cord-010092-uftc8inx 3291 72 % % NN cord-010092-uftc8inx 3291 73 , , , cord-010092-uftc8inx 3291 74 anti anti JJ cord-010092-uftc8inx 3291 75 - - NNP cord-010092-uftc8inx 3291 76 S S NNP cord-010092-uftc8inx 3291 77 3 3 CD cord-010092-uftc8inx 3291 78 % % NN cord-010092-uftc8inx 3291 79 , , , cord-010092-uftc8inx 3291 80 antis antis NNPS cord-010092-uftc8inx 3291 81 1 1 CD cord-010092-uftc8inx 3291 82 % % NN cord-010092-uftc8inx 3291 83 , , , cord-010092-uftc8inx 3291 84 anti anti JJ cord-010092-uftc8inx 3291 85 - - NNP cord-010092-uftc8inx 3291 86 Kp Kp NNP cord-010092-uftc8inx 3291 87 a a DT cord-010092-uftc8inx 3291 88 0.7 0.7 CD cord-010092-uftc8inx 3291 89 % % NN cord-010092-uftc8inx 3291 90 , , , cord-010092-uftc8inx 3291 91 anti anti JJ cord-010092-uftc8inx 3291 92 - - JJ cord-010092-uftc8inx 3291 93 Fy Fy NNP cord-010092-uftc8inx 3291 94 b b NNP cord-010092-uftc8inx 3291 95 0.3 0.3 CD cord-010092-uftc8inx 3291 96 % % NN cord-010092-uftc8inx 3291 97 and and CC cord-010092-uftc8inx 3291 98 IgM IgM NNP cord-010092-uftc8inx 3291 99 being be VBG cord-010092-uftc8inx 3291 100 2 2 CD cord-010092-uftc8inx 3291 101 % % NN cord-010092-uftc8inx 3291 102 . . . cord-010092-uftc8inx 3292 1 Summary Summary NNP cord-010092-uftc8inx 3292 2 / / SYM cord-010092-uftc8inx 3292 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 3292 4 : : : cord-010092-uftc8inx 3293 1 RBC RBC NNP cord-010092-uftc8inx 3293 2 alloimmunisation alloimmunisation NN cord-010092-uftc8inx 3293 3 rate rate NN cord-010092-uftc8inx 3293 4 is be VBZ cord-010092-uftc8inx 3293 5 high high JJ cord-010092-uftc8inx 3293 6 in in IN cord-010092-uftc8inx 3293 7 Oman Oman NNP cord-010092-uftc8inx 3293 8 majority majority NN cord-010092-uftc8inx 3293 9 of of IN cord-010092-uftc8inx 3293 10 the the DT cord-010092-uftc8inx 3293 11 patient patient NN cord-010092-uftc8inx 3293 12 affected affect VBN cord-010092-uftc8inx 3293 13 are be VBP cord-010092-uftc8inx 3293 14 female female JJ cord-010092-uftc8inx 3293 15 . . . cord-010092-uftc8inx 3294 1 Interestingly interestingly RB cord-010092-uftc8inx 3294 2 sickle sickle NN cord-010092-uftc8inx 3294 3 trait trait NN cord-010092-uftc8inx 3294 4 patients patient NNS cord-010092-uftc8inx 3294 5 were be VBD cord-010092-uftc8inx 3294 6 also also RB cord-010092-uftc8inx 3294 7 transfused transfuse VBN cord-010092-uftc8inx 3294 8 and and CC cord-010092-uftc8inx 3294 9 19 19 CD cord-010092-uftc8inx 3294 10 % % NN cord-010092-uftc8inx 3294 11 of of IN cord-010092-uftc8inx 3294 12 them -PRON- PRP cord-010092-uftc8inx 3294 13 developed develop VBD cord-010092-uftc8inx 3294 14 alloantibodies alloantibody NNS cord-010092-uftc8inx 3294 15 . . . cord-010092-uftc8inx 3295 1 The the DT cord-010092-uftc8inx 3295 2 practice practice NN cord-010092-uftc8inx 3295 3 of of IN cord-010092-uftc8inx 3295 4 transfusing transfuse VBG cord-010092-uftc8inx 3295 5 Rh Rh NNP cord-010092-uftc8inx 3295 6 and and CC cord-010092-uftc8inx 3295 7 Kell Kell NNP cord-010092-uftc8inx 3295 8 matching match VBG cord-010092-uftc8inx 3295 9 blood blood NN cord-010092-uftc8inx 3295 10 unit unit NN cord-010092-uftc8inx 3295 11 is be VBZ cord-010092-uftc8inx 3295 12 implemented implement VBN cord-010092-uftc8inx 3295 13 four four CD cord-010092-uftc8inx 3295 14 years year NNS cord-010092-uftc8inx 3295 15 ago ago RB cord-010092-uftc8inx 3295 16 and and CC cord-010092-uftc8inx 3295 17 still still RB cord-010092-uftc8inx 3295 18 high high JJ cord-010092-uftc8inx 3295 19 alloimmunization alloimmunization NN cord-010092-uftc8inx 3295 20 percentage percentage NN cord-010092-uftc8inx 3295 21 is be VBZ cord-010092-uftc8inx 3295 22 achieved achieve VBN cord-010092-uftc8inx 3295 23 . . . cord-010092-uftc8inx 3296 1 Background background NN cord-010092-uftc8inx 3296 2 : : : cord-010092-uftc8inx 3297 1 In in IN cord-010092-uftc8inx 3297 2 Ghana Ghana NNP cord-010092-uftc8inx 3297 3 , , , cord-010092-uftc8inx 3297 4 routine routine JJ cord-010092-uftc8inx 3297 5 pre pre JJ cord-010092-uftc8inx 3297 6 - - JJ cord-010092-uftc8inx 3297 7 transfusion transfusion JJ cord-010092-uftc8inx 3297 8 investigations investigation NNS cord-010092-uftc8inx 3297 9 for for IN cord-010092-uftc8inx 3297 10 patients patient NNS cord-010092-uftc8inx 3297 11 with with IN cord-010092-uftc8inx 3297 12 sickle sickle NN cord-010092-uftc8inx 3297 13 cell cell NN cord-010092-uftc8inx 3297 14 disease disease NN cord-010092-uftc8inx 3297 15 ( ( -LRB- cord-010092-uftc8inx 3297 16 SCD SCD NNP cord-010092-uftc8inx 3297 17 ) ) -RRB- cord-010092-uftc8inx 3297 18 involve involve VBP cord-010092-uftc8inx 3297 19 only only RB cord-010092-uftc8inx 3297 20 ABO ABO NNP cord-010092-uftc8inx 3297 21 - - HYPH cord-010092-uftc8inx 3297 22 D D NNP cord-010092-uftc8inx 3297 23 typing typing NN cord-010092-uftc8inx 3297 24 and and CC cord-010092-uftc8inx 3297 25 immediate immediate JJ cord-010092-uftc8inx 3297 26 spin spin NN cord-010092-uftc8inx 3297 27 crossmatch crossmatch NN cord-010092-uftc8inx 3297 28 , , , cord-010092-uftc8inx 3297 29 without without IN cord-010092-uftc8inx 3297 30 screening screen VBG cord-010092-uftc8inx 3297 31 for for IN cord-010092-uftc8inx 3297 32 irregular irregular JJ cord-010092-uftc8inx 3297 33 RBC RBC NNP cord-010092-uftc8inx 3297 34 antibodies antibody NNS cord-010092-uftc8inx 3297 35 Aims aim VBZ cord-010092-uftc8inx 3297 36 : : : cord-010092-uftc8inx 3298 1 Determine determine VB cord-010092-uftc8inx 3298 2 the the DT cord-010092-uftc8inx 3298 3 prevalence prevalence NN cord-010092-uftc8inx 3298 4 and and CC cord-010092-uftc8inx 3298 5 specificities specificity NNS cord-010092-uftc8inx 3298 6 of of IN cord-010092-uftc8inx 3298 7 and and CC cord-010092-uftc8inx 3298 8 risk risk NN cord-010092-uftc8inx 3298 9 factors factor NNS cord-010092-uftc8inx 3298 10 for for IN cord-010092-uftc8inx 3298 11 RBC RBC NNP cord-010092-uftc8inx 3298 12 alloantibodies alloantibody NNS cord-010092-uftc8inx 3298 13 in in IN cord-010092-uftc8inx 3298 14 multi multi JJ cord-010092-uftc8inx 3298 15 - - JJ cord-010092-uftc8inx 3298 16 transfused transfused JJ cord-010092-uftc8inx 3298 17 patients patient NNS cord-010092-uftc8inx 3298 18 with with IN cord-010092-uftc8inx 3298 19 SCD SCD NNP cord-010092-uftc8inx 3298 20 Methods Methods NNPS cord-010092-uftc8inx 3298 21 : : : cord-010092-uftc8inx 3298 22 In in IN cord-010092-uftc8inx 3298 23 2018 2018 CD cord-010092-uftc8inx 3298 24 , , , cord-010092-uftc8inx 3298 25 a a DT cord-010092-uftc8inx 3298 26 cross cross JJ cord-010092-uftc8inx 3298 27 - - JJ cord-010092-uftc8inx 3298 28 sectional sectional JJ cord-010092-uftc8inx 3298 29 study study NN cord-010092-uftc8inx 3298 30 in in IN cord-010092-uftc8inx 3298 31 multi multi JJ cord-010092-uftc8inx 3298 32 - - JJ cord-010092-uftc8inx 3298 33 transfused transfused JJ cord-010092-uftc8inx 3298 34 patients patient NNS cord-010092-uftc8inx 3298 35 with with IN cord-010092-uftc8inx 3298 36 SCD SCD NNP cord-010092-uftc8inx 3298 37 , , , cord-010092-uftc8inx 3298 38 from from IN cord-010092-uftc8inx 3298 39 two two CD cord-010092-uftc8inx 3298 40 tertiary tertiary JJ cord-010092-uftc8inx 3298 41 hospitals hospital NNS cord-010092-uftc8inx 3298 42 in in IN cord-010092-uftc8inx 3298 43 Ghana Ghana NNP cord-010092-uftc8inx 3298 44 was be VBD cord-010092-uftc8inx 3298 45 performed perform VBN cord-010092-uftc8inx 3298 46 . . . cord-010092-uftc8inx 3299 1 Participants participant NNS cord-010092-uftc8inx 3299 2 ' ' POS cord-010092-uftc8inx 3299 3 data datum NNS cord-010092-uftc8inx 3299 4 on on IN cord-010092-uftc8inx 3299 5 demography demography NN cord-010092-uftc8inx 3299 6 , , , cord-010092-uftc8inx 3299 7 transfusion transfusion NN cord-010092-uftc8inx 3299 8 and and CC cord-010092-uftc8inx 3299 9 medical medical JJ cord-010092-uftc8inx 3299 10 history history NN cord-010092-uftc8inx 3299 11 were be VBD cord-010092-uftc8inx 3299 12 recorded record VBN cord-010092-uftc8inx 3299 13 . . . cord-010092-uftc8inx 3300 1 Antibody antibody NN cord-010092-uftc8inx 3300 2 screening screening NN cord-010092-uftc8inx 3300 3 and and CC cord-010092-uftc8inx 3300 4 identification identification NN cord-010092-uftc8inx 3300 5 tests test NNS cord-010092-uftc8inx 3300 6 were be VBD cord-010092-uftc8inx 3300 7 done do VBN cord-010092-uftc8inx 3300 8 at at IN cord-010092-uftc8inx 3300 9 Sanquin Sanquin NNP cord-010092-uftc8inx 3300 10 , , , cord-010092-uftc8inx 3300 11 the the DT cord-010092-uftc8inx 3300 12 Netherlands Netherlands NNP cord-010092-uftc8inx 3300 13 , , , cord-010092-uftc8inx 3300 14 with with IN cord-010092-uftc8inx 3300 15 standard standard JJ cord-010092-uftc8inx 3300 16 serology serology NN cord-010092-uftc8inx 3300 17 using use VBG cord-010092-uftc8inx 3300 18 LISS LISS NNP cord-010092-uftc8inx 3300 19 as as IN cord-010092-uftc8inx 3300 20 enhancer enhancer NN cord-010092-uftc8inx 3300 21 and and CC cord-010092-uftc8inx 3300 22 with with IN cord-010092-uftc8inx 3300 23 papain papain NN cord-010092-uftc8inx 3300 24 treated treat VBN cord-010092-uftc8inx 3300 25 RBC RBC NNP cord-010092-uftc8inx 3300 26 panel panel NN cord-010092-uftc8inx 3300 27 cells cell NNS cord-010092-uftc8inx 3300 28 ( ( -LRB- cord-010092-uftc8inx 3300 29 ' ' `` cord-010092-uftc8inx 3300 30 enzyme enzyme NN cord-010092-uftc8inx 3300 31 only only RB cord-010092-uftc8inx 3300 32 ' ' '' cord-010092-uftc8inx 3300 33 ) ) -RRB- cord-010092-uftc8inx 3300 34 . . . cord-010092-uftc8inx 3301 1 Characterization characterization NN cord-010092-uftc8inx 3301 2 of of IN cord-010092-uftc8inx 3301 3 RHD RHD NNP cord-010092-uftc8inx 3301 4 genes gene NNS cord-010092-uftc8inx 3301 5 was be VBD cord-010092-uftc8inx 3301 6 done do VBN cord-010092-uftc8inx 3301 7 by by IN cord-010092-uftc8inx 3301 8 Multiplex Multiplex NNP cord-010092-uftc8inx 3301 9 Ligase Ligase NNP cord-010092-uftc8inx 3301 10 Amplification Amplification NNP cord-010092-uftc8inx 3301 11 Assay Assay NNP cord-010092-uftc8inx 3301 12 . . . cord-010092-uftc8inx 3302 1 Logistic logistic JJ cord-010092-uftc8inx 3302 2 regression regression NN cord-010092-uftc8inx 3302 3 was be VBD cord-010092-uftc8inx 3302 4 used use VBN cord-010092-uftc8inx 3302 5 to to TO cord-010092-uftc8inx 3302 6 determine determine VB cord-010092-uftc8inx 3302 7 the the DT cord-010092-uftc8inx 3302 8 association association NN cord-010092-uftc8inx 3302 9 of of IN cord-010092-uftc8inx 3302 10 patient patient JJ cord-010092-uftc8inx 3302 11 characteristics characteristic NNS cord-010092-uftc8inx 3302 12 , , , cord-010092-uftc8inx 3302 13 i.e. i.e. FW cord-010092-uftc8inx 3302 14 sex sex NN cord-010092-uftc8inx 3302 15 , , , cord-010092-uftc8inx 3302 16 age age NN cord-010092-uftc8inx 3302 17 at at IN cord-010092-uftc8inx 3302 18 enrollment enrollment NN cord-010092-uftc8inx 3302 19 ( ( -LRB- cord-010092-uftc8inx 3302 20 continuous continuous JJ cord-010092-uftc8inx 3302 21 ) ) -RRB- cord-010092-uftc8inx 3302 22 , , , cord-010092-uftc8inx 3302 23 age age NN cord-010092-uftc8inx 3302 24 at at IN cord-010092-uftc8inx 3302 25 first first JJ cord-010092-uftc8inx 3302 26 transfusion transfusion NN cord-010092-uftc8inx 3302 27 ( ( -LRB- cord-010092-uftc8inx 3302 28 categorized categorize VBN cord-010092-uftc8inx 3302 29 as as IN cord-010092-uftc8inx 3302 30 ≤ ≤ NNP cord-010092-uftc8inx 3302 31 1 1 CD cord-010092-uftc8inx 3302 32 , , , cord-010092-uftc8inx 3302 33 2 2 CD cord-010092-uftc8inx 3302 34 - - SYM cord-010092-uftc8inx 3302 35 5 5 CD cord-010092-uftc8inx 3302 36 , , , cord-010092-uftc8inx 3302 37 6 6 CD cord-010092-uftc8inx 3302 38 - - SYM cord-010092-uftc8inx 3302 39 9 9 CD cord-010092-uftc8inx 3302 40 and and CC cord-010092-uftc8inx 3302 41 ≥10 ≥10 NNP cord-010092-uftc8inx 3302 42 ) ) -RRB- cord-010092-uftc8inx 3302 43 , , , cord-010092-uftc8inx 3302 44 previous previous JJ cord-010092-uftc8inx 3302 45 pregnancy pregnancy NN cord-010092-uftc8inx 3302 46 , , , cord-010092-uftc8inx 3302 47 number number NN cord-010092-uftc8inx 3302 48 of of IN cord-010092-uftc8inx 3302 49 transfused transfuse VBN cord-010092-uftc8inx 3302 50 units unit NNS cord-010092-uftc8inx 3302 51 ( ( -LRB- cord-010092-uftc8inx 3302 52 2 2 CD cord-010092-uftc8inx 3302 53 , , , cord-010092-uftc8inx 3302 54 3 3 CD cord-010092-uftc8inx 3302 55 - - SYM cord-010092-uftc8inx 3302 56 5 5 CD cord-010092-uftc8inx 3302 57 and and CC cord-010092-uftc8inx 3302 58 6 6 CD cord-010092-uftc8inx 3302 59 - - SYM cord-010092-uftc8inx 3302 60 10 10 CD cord-010092-uftc8inx 3302 61 and and CC cord-010092-uftc8inx 3302 62 > > XX cord-010092-uftc8inx 3302 63 10 10 CD cord-010092-uftc8inx 3302 64 ) ) -RRB- cord-010092-uftc8inx 3302 65 , , , cord-010092-uftc8inx 3302 66 and and CC cord-010092-uftc8inx 3302 67 years year NNS cord-010092-uftc8inx 3302 68 after after IN cord-010092-uftc8inx 3302 69 last last JJ cord-010092-uftc8inx 3302 70 transfusion transfusion NN cord-010092-uftc8inx 3302 71 ( ( -LRB- cord-010092-uftc8inx 3302 72 < < NNP cord-010092-uftc8inx 3302 73 1 1 CD cord-010092-uftc8inx 3302 74 , , , cord-010092-uftc8inx 3302 75 1 1 CD cord-010092-uftc8inx 3302 76 - - SYM cord-010092-uftc8inx 3302 77 2 2 CD cord-010092-uftc8inx 3302 78 , , , cord-010092-uftc8inx 3302 79 2 2 CD cord-010092-uftc8inx 3302 80 - - SYM cord-010092-uftc8inx 3302 81 5 5 CD cord-010092-uftc8inx 3302 82 , , , cord-010092-uftc8inx 3302 83 > > XX cord-010092-uftc8inx 3302 84 5y 5y CD cord-010092-uftc8inx 3302 85 ) ) -RRB- cord-010092-uftc8inx 3302 86 with with IN cord-010092-uftc8inx 3302 87 presence presence NN cord-010092-uftc8inx 3302 88 of of IN cord-010092-uftc8inx 3302 89 alloantibodies alloantibody NNS cord-010092-uftc8inx 3302 90 Results result NNS cord-010092-uftc8inx 3302 91 : : : cord-010092-uftc8inx 3302 92 226 226 CD cord-010092-uftc8inx 3302 93 patients patient NNS cord-010092-uftc8inx 3302 94 ( ( -LRB- cord-010092-uftc8inx 3302 95 100 100 CD cord-010092-uftc8inx 3302 96 males male NNS cord-010092-uftc8inx 3302 97 and and CC cord-010092-uftc8inx 3302 98 126 126 CD cord-010092-uftc8inx 3302 99 females female NNS cord-010092-uftc8inx 3302 100 , , , cord-010092-uftc8inx 3302 101 median median JJ cord-010092-uftc8inx 3302 102 age age NN cord-010092-uftc8inx 3302 103 17 17 CD cord-010092-uftc8inx 3302 104 years year NNS cord-010092-uftc8inx 3302 105 , , , cord-010092-uftc8inx 3302 106 range range VBP cord-010092-uftc8inx 3302 107 1.7 1.7 CD cord-010092-uftc8inx 3302 108 - - SYM cord-010092-uftc8inx 3302 109 66 66 CD cord-010092-uftc8inx 3302 110 ) ) -RRB- cord-010092-uftc8inx 3302 111 were be VBD cord-010092-uftc8inx 3302 112 included include VBN cord-010092-uftc8inx 3302 113 . . . cord-010092-uftc8inx 3303 1 The the DT cord-010092-uftc8inx 3303 2 median median JJ cord-010092-uftc8inx 3303 3 number number NN cord-010092-uftc8inx 3303 4 of of IN cord-010092-uftc8inx 3303 5 transfusions transfusion NNS cord-010092-uftc8inx 3303 6 was be VBD cord-010092-uftc8inx 3303 7 3 3 CD cord-010092-uftc8inx 3304 1 ( ( -LRB- cord-010092-uftc8inx 3304 2 range range NNP cord-010092-uftc8inx 3304 3 2 2 CD cord-010092-uftc8inx 3304 4 - - SYM cord-010092-uftc8inx 3304 5 40 40 CD cord-010092-uftc8inx 3304 6 ) ) -RRB- cord-010092-uftc8inx 3304 7 . . . cord-010092-uftc8inx 3305 1 The the DT cord-010092-uftc8inx 3305 2 median median JJ cord-010092-uftc8inx 3305 3 years year NNS cord-010092-uftc8inx 3305 4 after after IN cord-010092-uftc8inx 3305 5 last last JJ cord-010092-uftc8inx 3305 6 transfusion transfusion NN cord-010092-uftc8inx 3305 7 was be VBD cord-010092-uftc8inx 3305 8 2 2 CD cord-010092-uftc8inx 3305 9 ( ( -LRB- cord-010092-uftc8inx 3305 10 range range NN cord-010092-uftc8inx 3305 11 2 2 CD cord-010092-uftc8inx 3305 12 weeks-55.5 weeks-55.5 NNP cord-010092-uftc8inx 3305 13 years year NNS cord-010092-uftc8inx 3305 14 ) ) -RRB- cord-010092-uftc8inx 3305 15 . . . cord-010092-uftc8inx 3306 1 In in IN cord-010092-uftc8inx 3306 2 56 56 CD cord-010092-uftc8inx 3306 3 patients patient NNS cord-010092-uftc8inx 3306 4 , , , cord-010092-uftc8inx 3306 5 anti anti JJ cord-010092-uftc8inx 3306 6 - - JJ cord-010092-uftc8inx 3306 7 RBC RBC NNP cord-010092-uftc8inx 3306 8 antibodies antibody NNS cord-010092-uftc8inx 3306 9 were be VBD cord-010092-uftc8inx 3306 10 detected detect VBN cord-010092-uftc8inx 3306 11 . . . cord-010092-uftc8inx 3307 1 In in IN cord-010092-uftc8inx 3307 2 14 14 CD cord-010092-uftc8inx 3307 3 of of IN cord-010092-uftc8inx 3307 4 them -PRON- PRP cord-010092-uftc8inx 3307 5 the the DT cord-010092-uftc8inx 3307 6 antibodies antibody NNS cord-010092-uftc8inx 3307 7 were be VBD cord-010092-uftc8inx 3307 8 weakly weakly RB cord-010092-uftc8inx 3307 9 reactive reactive JJ cord-010092-uftc8inx 3307 10 with with IN cord-010092-uftc8inx 3307 11 enzyme enzyme NN cord-010092-uftc8inx 3307 12 treated treat VBN cord-010092-uftc8inx 3307 13 cells cell NNS cord-010092-uftc8inx 3307 14 only only RB cord-010092-uftc8inx 3307 15 or or CC cord-010092-uftc8inx 3307 16 pan pan JJ cord-010092-uftc8inx 3307 17 - - JJ cord-010092-uftc8inx 3307 18 reactive reactive JJ cord-010092-uftc8inx 3307 19 , , , cord-010092-uftc8inx 3308 1 possibly possibly RB cord-010092-uftc8inx 3308 2 some some DT cord-010092-uftc8inx 3308 3 of of IN cord-010092-uftc8inx 3308 4 them -PRON- PRP cord-010092-uftc8inx 3308 5 representing represent VBG cord-010092-uftc8inx 3308 6 autoantibodies autoantibody NNS cord-010092-uftc8inx 3308 7 or or CC cord-010092-uftc8inx 3308 8 antibodies antibody NNS cord-010092-uftc8inx 3308 9 against against IN cord-010092-uftc8inx 3308 10 high high JJ cord-010092-uftc8inx 3308 11 frequency frequency NN cord-010092-uftc8inx 3308 12 antigens antigen NNS cord-010092-uftc8inx 3308 13 . . . cord-010092-uftc8inx 3309 1 In in IN cord-010092-uftc8inx 3309 2 seven seven CD cord-010092-uftc8inx 3309 3 patients patient NNS cord-010092-uftc8inx 3309 4 enzyme enzyme NN cord-010092-uftc8inx 3309 5 - - HYPH cord-010092-uftc8inx 3309 6 only only JJ cord-010092-uftc8inx 3309 7 anti anti JJ cord-010092-uftc8inx 3309 8 - - NNP cord-010092-uftc8inx 3309 9 Le Le NNP cord-010092-uftc8inx 3309 10 a a NNP cord-010092-uftc8inx 3309 11 was be VBD cord-010092-uftc8inx 3309 12 demonstrated demonstrate VBN cord-010092-uftc8inx 3309 13 , , , cord-010092-uftc8inx 3309 14 likely likely RB cord-010092-uftc8inx 3309 15 naturally naturally RB cord-010092-uftc8inx 3309 16 occurring occur VBG cord-010092-uftc8inx 3309 17 antibodies antibody NNS cord-010092-uftc8inx 3309 18 . . . cord-010092-uftc8inx 3310 1 Thus thus RB cord-010092-uftc8inx 3310 2 , , , cord-010092-uftc8inx 3310 3 in in IN cord-010092-uftc8inx 3310 4 at at RB cord-010092-uftc8inx 3310 5 least least JJS cord-010092-uftc8inx 3310 6 34 34 CD cord-010092-uftc8inx 3310 7 patients patient NNS cord-010092-uftc8inx 3310 8 ( ( -LRB- cord-010092-uftc8inx 3310 9 15.0 15.0 CD cord-010092-uftc8inx 3310 10 % % NN cord-010092-uftc8inx 3310 11 ) ) -RRB- cord-010092-uftc8inx 3310 12 alloimmunization alloimmunization NN cord-010092-uftc8inx 3310 13 was be VBD cord-010092-uftc8inx 3310 14 demonstrated demonstrate VBN cord-010092-uftc8inx 3310 15 or or CC cord-010092-uftc8inx 3310 16 suspected suspect VBN cord-010092-uftc8inx 3310 17 ; ; : cord-010092-uftc8inx 3310 18 in in IN cord-010092-uftc8inx 3310 19 11 11 CD cord-010092-uftc8inx 3310 20 patients patient NNS cord-010092-uftc8inx 3310 21 the the DT cord-010092-uftc8inx 3310 22 alloantibodies alloantibody NNS cord-010092-uftc8inx 3310 23 were be VBD cord-010092-uftc8inx 3310 24 ' ' `` cord-010092-uftc8inx 3310 25 enzyme enzyme NN cord-010092-uftc8inx 3310 26 only only RB cord-010092-uftc8inx 3310 27 ' ' '' cord-010092-uftc8inx 3310 28 . . . cord-010092-uftc8inx 3311 1 Besides besides RB cord-010092-uftc8inx 3311 2 , , , cord-010092-uftc8inx 3311 3 the the DT cord-010092-uftc8inx 3311 4 36 36 CD cord-010092-uftc8inx 3311 5 alloantibodies alloantibody NNS cord-010092-uftc8inx 3311 6 of of IN cord-010092-uftc8inx 3311 7 known know VBN cord-010092-uftc8inx 3311 8 specificity specificity NN cord-010092-uftc8inx 3311 9 ( ( -LRB- cord-010092-uftc8inx 3311 10 8 8 CD cord-010092-uftc8inx 3311 11 anti anti JJ cord-010092-uftc8inx 3311 12 - - JJ cord-010092-uftc8inx 3311 13 D d JJ cord-010092-uftc8inx 3311 14 , , , cord-010092-uftc8inx 3311 15 2 2 CD cord-010092-uftc8inx 3311 16 anti anti JJ cord-010092-uftc8inx 3311 17 - - JJ cord-010092-uftc8inx 3311 18 D+C d+c JJ cord-010092-uftc8inx 3311 19 , , , cord-010092-uftc8inx 3311 20 16 16 CD cord-010092-uftc8inx 3311 21 anti anti JJ cord-010092-uftc8inx 3311 22 - - JJ cord-010092-uftc8inx 3311 23 E e JJ cord-010092-uftc8inx 3311 24 , , , cord-010092-uftc8inx 3311 25 1 1 CD cord-010092-uftc8inx 3311 26 anti anti NNP cord-010092-uftc8inx 3311 27 - - NNP cord-010092-uftc8inx 3311 28 C C NNP cord-010092-uftc8inx 3311 29 , , , cord-010092-uftc8inx 3311 30 3 3 CD cord-010092-uftc8inx 3311 31 anti anti NN cord-010092-uftc8inx 3311 32 - - NN cord-010092-uftc8inx 3311 33 e e JJ cord-010092-uftc8inx 3311 34 , , , cord-010092-uftc8inx 3311 35 1 1 CD cord-010092-uftc8inx 3311 36 Anti Anti NNP cord-010092-uftc8inx 3311 37 - - NNP cord-010092-uftc8inx 3311 38 K K NNP cord-010092-uftc8inx 3311 39 , , , cord-010092-uftc8inx 3311 40 1 1 CD cord-010092-uftc8inx 3311 41 anti anti NNP cord-010092-uftc8inx 3311 42 - - NNP cord-010092-uftc8inx 3311 43 s s JJ cord-010092-uftc8inx 3311 44 , , , cord-010092-uftc8inx 3311 45 1 1 CD cord-010092-uftc8inx 3311 46 anti anti NNP cord-010092-uftc8inx 3311 47 - - NNP cord-010092-uftc8inx 3311 48 Le Le NNP cord-010092-uftc8inx 3311 49 a a NNP cord-010092-uftc8inx 3311 50 , , , cord-010092-uftc8inx 3311 51 1 1 CD cord-010092-uftc8inx 3311 52 anti anti JJ cord-010092-uftc8inx 3311 53 - - JJ cord-010092-uftc8inx 3311 54 Go go VB cord-010092-uftc8inx 3311 55 a a DT cord-010092-uftc8inx 3311 56 ) ) -RRB- cord-010092-uftc8inx 3311 57 , , , cord-010092-uftc8inx 3311 58 three three CD cord-010092-uftc8inx 3311 59 antibodies antibody NNS cord-010092-uftc8inx 3311 60 reactive reactive JJ cord-010092-uftc8inx 3311 61 only only RB cord-010092-uftc8inx 3311 62 with with IN cord-010092-uftc8inx 3311 63 Fy(a Fy(a NNP cord-010092-uftc8inx 3311 64 - - HYPH cord-010092-uftc8inx 3311 65 b- b- NNP cord-010092-uftc8inx 3311 66 ) ) -RRB- cord-010092-uftc8inx 3311 67 cells cell NNS cord-010092-uftc8inx 3311 68 and and CC cord-010092-uftc8inx 3311 69 two two CD cord-010092-uftc8inx 3311 70 antibodies antibody NNS cord-010092-uftc8inx 3311 71 of of IN cord-010092-uftc8inx 3311 72 yet yet RB cord-010092-uftc8inx 3311 73 unidentified unidentified JJ cord-010092-uftc8inx 3311 74 specificity specificity NN cord-010092-uftc8inx 3311 75 were be VBD cord-010092-uftc8inx 3311 76 detected detect VBN cord-010092-uftc8inx 3311 77 . . . cord-010092-uftc8inx 3312 1 In in IN cord-010092-uftc8inx 3312 2 six six CD cord-010092-uftc8inx 3312 3 D d NN cord-010092-uftc8inx 3312 4 - - HYPH cord-010092-uftc8inx 3312 5 patients patient NNS cord-010092-uftc8inx 3312 6 ( ( -LRB- cord-010092-uftc8inx 3312 7 3 3 CD cord-010092-uftc8inx 3312 8 had have VBD cord-010092-uftc8inx 3312 9 been be VBN cord-010092-uftc8inx 3312 10 pregnant pregnant JJ cord-010092-uftc8inx 3312 11 ) ) -RRB- cord-010092-uftc8inx 3313 1 anti anti JJ cord-010092-uftc8inx 3313 2 - - JJ cord-010092-uftc8inx 3313 3 D d JJ cord-010092-uftc8inx 3313 4 ( ( -LRB- cord-010092-uftc8inx 3313 5 together together RB cord-010092-uftc8inx 3313 6 with with IN cord-010092-uftc8inx 3313 7 anti anti JJ cord-010092-uftc8inx 3313 8 - - NNP cord-010092-uftc8inx 3313 9 C C NNP cord-010092-uftc8inx 3313 10 in in IN cord-010092-uftc8inx 3313 11 two two CD cord-010092-uftc8inx 3313 12 patients patient NNS cord-010092-uftc8inx 3313 13 ) ) -RRB- cord-010092-uftc8inx 3313 14 was be VBD cord-010092-uftc8inx 3313 15 found find VBN cord-010092-uftc8inx 3313 16 . . . cord-010092-uftc8inx 3314 1 In in IN cord-010092-uftc8inx 3314 2 three three CD cord-010092-uftc8inx 3314 3 out out IN cord-010092-uftc8inx 3314 4 of of IN cord-010092-uftc8inx 3314 5 four four CD cord-010092-uftc8inx 3314 6 D+ D+ NNS cord-010092-uftc8inx 3314 7 patients patient NNS cord-010092-uftc8inx 3314 8 with with IN cord-010092-uftc8inx 3314 9 anti anti JJ cord-010092-uftc8inx 3314 10 - - JJ cord-010092-uftc8inx 3314 11 D d JJ cord-010092-uftc8inx 3314 12 , , , cord-010092-uftc8inx 3314 13 an an DT cord-010092-uftc8inx 3314 14 RHD RHD NNP cord-010092-uftc8inx 3314 15 variant variant NN cord-010092-uftc8inx 3314 16 gene gene NN cord-010092-uftc8inx 3314 17 was be VBD cord-010092-uftc8inx 3314 18 demonstrated demonstrate VBN cord-010092-uftc8inx 3314 19 ( ( -LRB- cord-010092-uftc8inx 3314 20 2 2 CD cord-010092-uftc8inx 3314 21 DAU dau NN cord-010092-uftc8inx 3314 22 - - HYPH cord-010092-uftc8inx 3314 23 alleles allele NNS cord-010092-uftc8inx 3314 24 and and CC cord-010092-uftc8inx 3314 25 1 1 CD cord-010092-uftc8inx 3314 26 DIII DIII NNP cord-010092-uftc8inx 3314 27 type type NN cord-010092-uftc8inx 3314 28 4 4 CD cord-010092-uftc8inx 3314 29 or or CC cord-010092-uftc8inx 3314 30 DIVa-2 diva-2 NN cord-010092-uftc8inx 3314 31 ) ) -RRB- cord-010092-uftc8inx 3314 32 . . . cord-010092-uftc8inx 3315 1 Logistic logistic JJ cord-010092-uftc8inx 3315 2 regression regression NN cord-010092-uftc8inx 3315 3 revealed reveal VBD cord-010092-uftc8inx 3315 4 that that IN cord-010092-uftc8inx 3315 5 none none NN cord-010092-uftc8inx 3315 6 of of IN cord-010092-uftc8inx 3315 7 the the DT cord-010092-uftc8inx 3315 8 risk risk NN cord-010092-uftc8inx 3315 9 factors factor NNS cord-010092-uftc8inx 3315 10 analysed analyse VBN cord-010092-uftc8inx 3315 11 was be VBD cord-010092-uftc8inx 3315 12 associated associate VBN cord-010092-uftc8inx 3315 13 with with IN cord-010092-uftc8inx 3315 14 the the DT cord-010092-uftc8inx 3315 15 presence presence NN cord-010092-uftc8inx 3315 16 of of IN cord-010092-uftc8inx 3315 17 antibodies antibody NNS cord-010092-uftc8inx 3315 18 in in IN cord-010092-uftc8inx 3315 19 the the DT cord-010092-uftc8inx 3315 20 34 34 CD cord-010092-uftc8inx 3315 21 patients patient NNS cord-010092-uftc8inx 3315 22 . . . cord-010092-uftc8inx 3316 1 Immunobiology Immunobiology NNP cord-010092-uftc8inx 3316 2 -Red -Red NNP cord-010092-uftc8inx 3316 3 Cell Cell NNP cord-010092-uftc8inx 3316 4 Alloimmunity Alloimmunity NNP cord-010092-uftc8inx 3317 1 65 65 CD cord-010092-uftc8inx 3317 2 Fifty fifty CD cord-010092-uftc8inx 3317 3 - - HYPH cord-010092-uftc8inx 3317 4 eight eight CD cord-010092-uftc8inx 3317 5 patients patient NNS cord-010092-uftc8inx 3317 6 , , , cord-010092-uftc8inx 3317 7 had have VBD cord-010092-uftc8inx 3317 8 experienced experience VBN cord-010092-uftc8inx 3317 9 an an DT cord-010092-uftc8inx 3317 10 adverse adverse JJ cord-010092-uftc8inx 3317 11 reaction reaction NN cord-010092-uftc8inx 3317 12 during during IN cord-010092-uftc8inx 3317 13 or or CC cord-010092-uftc8inx 3317 14 shortly shortly RB cord-010092-uftc8inx 3317 15 after after IN cord-010092-uftc8inx 3317 16 transfusion transfusion NN cord-010092-uftc8inx 3317 17 ( ( -LRB- cord-010092-uftc8inx 3317 18 12 12 CD cord-010092-uftc8inx 3317 19 patients patient NNS cord-010092-uftc8inx 3317 20 had have VBD cord-010092-uftc8inx 3317 21 dark dark JJ cord-010092-uftc8inx 3317 22 urine urine NN cord-010092-uftc8inx 3317 23 ) ) -RRB- cord-010092-uftc8inx 3317 24 . . . cord-010092-uftc8inx 3318 1 Adverse adverse JJ cord-010092-uftc8inx 3318 2 reactions reaction NNS cord-010092-uftc8inx 3318 3 were be VBD cord-010092-uftc8inx 3318 4 associated associate VBN cord-010092-uftc8inx 3318 5 with with IN cord-010092-uftc8inx 3318 6 the the DT cord-010092-uftc8inx 3318 7 number number NN cord-010092-uftc8inx 3318 8 of of IN cord-010092-uftc8inx 3318 9 units unit NNS cord-010092-uftc8inx 3318 10 received receive VBN cord-010092-uftc8inx 3318 11 ( ( -LRB- cord-010092-uftc8inx 3318 12 OR or CC cord-010092-uftc8inx 3318 13 1.71 1.71 CD cord-010092-uftc8inx 3318 14 ( ( -LRB- cord-010092-uftc8inx 3318 15 95 95 CD cord-010092-uftc8inx 3318 16 % % NN cord-010092-uftc8inx 3318 17 CI CI NNP cord-010092-uftc8inx 3318 18 , , , cord-010092-uftc8inx 3318 19 1.25 1.25 CD cord-010092-uftc8inx 3318 20 - - SYM cord-010092-uftc8inx 3318 21 2.33 2.33 CD cord-010092-uftc8inx 3318 22 ; ; : cord-010092-uftc8inx 3318 23 P p NN cord-010092-uftc8inx 3318 24 = = SYM cord-010092-uftc8inx 3318 25 0.001 0.001 CD cord-010092-uftc8inx 3318 26 ) ) -RRB- cord-010092-uftc8inx 3318 27 , , , cord-010092-uftc8inx 3318 28 but but CC cord-010092-uftc8inx 3318 29 not not RB cord-010092-uftc8inx 3318 30 with with IN cord-010092-uftc8inx 3318 31 the the DT cord-010092-uftc8inx 3318 32 presence presence NN cord-010092-uftc8inx 3318 33 of of IN cord-010092-uftc8inx 3318 34 antibodies antibody NNS cord-010092-uftc8inx 3318 35 ( ( -LRB- cord-010092-uftc8inx 3318 36 P p NN cord-010092-uftc8inx 3318 37 > > XX cord-010092-uftc8inx 3319 1 0.7 0.7 LS cord-010092-uftc8inx 3319 2 ) ) -RRB- cord-010092-uftc8inx 3320 1 Summary Summary NNP cord-010092-uftc8inx 3320 2 / / SYM cord-010092-uftc8inx 3320 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 3320 4 : : : cord-010092-uftc8inx 3321 1 In in IN cord-010092-uftc8inx 3321 2 at at RB cord-010092-uftc8inx 3321 3 least least RBS cord-010092-uftc8inx 3321 4 15 15 CD cord-010092-uftc8inx 3321 5 % % NN cord-010092-uftc8inx 3321 6 of of IN cord-010092-uftc8inx 3321 7 multi multi JJ cord-010092-uftc8inx 3321 8 - - JJ cord-010092-uftc8inx 3321 9 transfused transfused JJ cord-010092-uftc8inx 3321 10 patients patient NNS cord-010092-uftc8inx 3321 11 with with IN cord-010092-uftc8inx 3321 12 SCD SCD NNP cord-010092-uftc8inx 3321 13 alloimmunization alloimmunization NN cord-010092-uftc8inx 3321 14 could could MD cord-010092-uftc8inx 3321 15 be be VB cord-010092-uftc8inx 3321 16 demonstrated demonstrate VBN cord-010092-uftc8inx 3321 17 , , , cord-010092-uftc8inx 3321 18 mainly mainly RB cord-010092-uftc8inx 3321 19 ( ( -LRB- cord-010092-uftc8inx 3321 20 80 80 CD cord-010092-uftc8inx 3321 21 % % NN cord-010092-uftc8inx 3321 22 ) ) -RRB- cord-010092-uftc8inx 3321 23 directed direct VBN cord-010092-uftc8inx 3321 24 against against IN cord-010092-uftc8inx 3321 25 Rh Rh NNP cord-010092-uftc8inx 3321 26 antigens antigen NNS cord-010092-uftc8inx 3321 27 . . . cord-010092-uftc8inx 3322 1 The the DT cord-010092-uftc8inx 3322 2 enzyme enzyme NN cord-010092-uftc8inx 3322 3 only only RB cord-010092-uftc8inx 3322 4 reactivity reactivity NN cord-010092-uftc8inx 3322 5 , , , cord-010092-uftc8inx 3322 6 coupled couple VBN cord-010092-uftc8inx 3322 7 with with IN cord-010092-uftc8inx 3322 8 absence absence NN cord-010092-uftc8inx 3322 9 of of IN cord-010092-uftc8inx 3322 10 antibodies antibody NNS cord-010092-uftc8inx 3322 11 in in IN cord-010092-uftc8inx 3322 12 seven seven CD cord-010092-uftc8inx 3322 13 of of IN cord-010092-uftc8inx 3322 14 12 12 CD cord-010092-uftc8inx 3322 15 patients patient NNS cord-010092-uftc8inx 3322 16 with with IN cord-010092-uftc8inx 3322 17 probable probable JJ cord-010092-uftc8inx 3322 18 haemolytic haemolytic JJ cord-010092-uftc8inx 3322 19 reaction reaction NN cord-010092-uftc8inx 3322 20 and and CC cord-010092-uftc8inx 3322 21 known know VBN cord-010092-uftc8inx 3322 22 evanescence evanescence NN cord-010092-uftc8inx 3322 23 of of IN cord-010092-uftc8inx 3322 24 especially especially RB cord-010092-uftc8inx 3322 25 non non JJ cord-010092-uftc8inx 3322 26 Rh Rh NNP cord-010092-uftc8inx 3322 27 antibodies antibody NNS cord-010092-uftc8inx 3322 28 suggest suggest VBP cord-010092-uftc8inx 3322 29 possible possible JJ cord-010092-uftc8inx 3322 30 low low JJ cord-010092-uftc8inx 3322 31 titre titre NN cord-010092-uftc8inx 3322 32 and and CC cord-010092-uftc8inx 3322 33 disappearance disappearance NN cord-010092-uftc8inx 3322 34 of of IN cord-010092-uftc8inx 3322 35 some some DT cord-010092-uftc8inx 3322 36 clinically clinically RB cord-010092-uftc8inx 3322 37 relevant relevant JJ cord-010092-uftc8inx 3322 38 antibodies antibody NNS cord-010092-uftc8inx 3322 39 . . . cord-010092-uftc8inx 3323 1 Given give VBN cord-010092-uftc8inx 3323 2 the the DT cord-010092-uftc8inx 3323 3 high high JJ cord-010092-uftc8inx 3323 4 immunization immunization NN cord-010092-uftc8inx 3323 5 rate rate NN cord-010092-uftc8inx 3323 6 together together RB cord-010092-uftc8inx 3323 7 with with IN cord-010092-uftc8inx 3323 8 the the DT cord-010092-uftc8inx 3323 9 high high JJ cord-010092-uftc8inx 3323 10 frequency frequency NN cord-010092-uftc8inx 3323 11 of of IN cord-010092-uftc8inx 3323 12 adverse adverse JJ cord-010092-uftc8inx 3323 13 transfusion transfusion NN cord-010092-uftc8inx 3323 14 reactions reaction NNS cord-010092-uftc8inx 3323 15 , , , cord-010092-uftc8inx 3323 16 pre pre JJ cord-010092-uftc8inx 3323 17 - - JJ cord-010092-uftc8inx 3323 18 transfusion transfusion JJ cord-010092-uftc8inx 3323 19 screening screening NN cord-010092-uftc8inx 3323 20 for for IN cord-010092-uftc8inx 3323 21 RBC RBC NNP cord-010092-uftc8inx 3323 22 antibodies antibody NNS cord-010092-uftc8inx 3323 23 should should MD cord-010092-uftc8inx 3323 24 be be VB cord-010092-uftc8inx 3323 25 considered consider VBN cord-010092-uftc8inx 3323 26 for for IN cord-010092-uftc8inx 3323 27 patients patient NNS cord-010092-uftc8inx 3323 28 with with IN cord-010092-uftc8inx 3323 29 SCD SCD NNP cord-010092-uftc8inx 3323 30 . . . cord-010092-uftc8inx 3324 1 Background background NN cord-010092-uftc8inx 3324 2 : : : cord-010092-uftc8inx 3325 1 Rh Rh NNP cord-010092-uftc8inx 3325 2 blood blood NN cord-010092-uftc8inx 3325 3 group group NN cord-010092-uftc8inx 3325 4 system system NN cord-010092-uftc8inx 3325 5 and and CC cord-010092-uftc8inx 3325 6 mainly mainly RB cord-010092-uftc8inx 3325 7 antigen antigen NNP cord-010092-uftc8inx 3325 8 D d NN cord-010092-uftc8inx 3325 9 is be VBZ cord-010092-uftc8inx 3325 10 one one CD cord-010092-uftc8inx 3325 11 of of IN cord-010092-uftc8inx 3325 12 the the DT cord-010092-uftc8inx 3325 13 most most RBS cord-010092-uftc8inx 3325 14 immunogenic immunogenic JJ cord-010092-uftc8inx 3325 15 , , , cord-010092-uftc8inx 3325 16 diverse diverse JJ cord-010092-uftc8inx 3325 17 and and CC cord-010092-uftc8inx 3325 18 clinically clinically RB cord-010092-uftc8inx 3325 19 important important JJ cord-010092-uftc8inx 3325 20 protein protein NN cord-010092-uftc8inx 3325 21 - - HYPH cord-010092-uftc8inx 3325 22 based base VBN cord-010092-uftc8inx 3325 23 blood blood NN cord-010092-uftc8inx 3325 24 group group NN cord-010092-uftc8inx 3325 25 . . . cord-010092-uftc8inx 3326 1 Antibody antibody NN cord-010092-uftc8inx 3326 2 anti anti JJ cord-010092-uftc8inx 3326 3 - - JJ cord-010092-uftc8inx 3326 4 D d JJ cord-010092-uftc8inx 3326 5 may may MD cord-010092-uftc8inx 3326 6 induce induce VB cord-010092-uftc8inx 3326 7 hemolytic hemolytic JJ cord-010092-uftc8inx 3326 8 transfusion transfusion NN cord-010092-uftc8inx 3326 9 reactions reaction NNS cord-010092-uftc8inx 3326 10 and and CC cord-010092-uftc8inx 3326 11 hemolytic hemolytic JJ cord-010092-uftc8inx 3326 12 disease disease NN cord-010092-uftc8inx 3326 13 of of IN cord-010092-uftc8inx 3326 14 the the DT cord-010092-uftc8inx 3326 15 fetus fetus NN cord-010092-uftc8inx 3326 16 and and CC cord-010092-uftc8inx 3326 17 newborn newborn JJ cord-010092-uftc8inx 3326 18 . . . cord-010092-uftc8inx 3327 1 Anti anti JJ cord-010092-uftc8inx 3327 2 - - JJ cord-010092-uftc8inx 3327 3 D d JJ cord-010092-uftc8inx 3327 4 prophylaxes prophylaxe NNS cord-010092-uftc8inx 3327 5 become become VBP cord-010092-uftc8inx 3327 6 ineffective ineffective JJ cord-010092-uftc8inx 3327 7 if if IN cord-010092-uftc8inx 3327 8 an an DT cord-010092-uftc8inx 3327 9 anti anti JJ cord-010092-uftc8inx 3327 10 - - JJ cord-010092-uftc8inx 3327 11 D d JJ cord-010092-uftc8inx 3327 12 immunization immunization NN cord-010092-uftc8inx 3327 13 has have VBZ cord-010092-uftc8inx 3327 14 occurred occur VBN cord-010092-uftc8inx 3327 15 . . . cord-010092-uftc8inx 3328 1 Approximately approximately RB cord-010092-uftc8inx 3328 2 1 1 CD cord-010092-uftc8inx 3328 3 % % NN cord-010092-uftc8inx 3328 4 of of IN cord-010092-uftc8inx 3328 5 the the DT cord-010092-uftc8inx 3328 6 D+ d+ NN cord-010092-uftc8inx 3328 7 population population NN cord-010092-uftc8inx 3328 8 carries carry VBZ cord-010092-uftc8inx 3328 9 RHD RHD NNP cord-010092-uftc8inx 3328 10 alleles allele NNS cord-010092-uftc8inx 3328 11 associated associate VBN cord-010092-uftc8inx 3328 12 with with IN cord-010092-uftc8inx 3328 13 reduced reduced JJ cord-010092-uftc8inx 3328 14 D d NN cord-010092-uftc8inx 3328 15 antigen antigen NN cord-010092-uftc8inx 3328 16 expression expression NN cord-010092-uftc8inx 3328 17 . . . cord-010092-uftc8inx 3329 1 Qualitative qualitative JJ cord-010092-uftc8inx 3329 2 variants variant NNS cord-010092-uftc8inx 3329 3 , , , cord-010092-uftc8inx 3329 4 in in IN cord-010092-uftc8inx 3329 5 which which WDT cord-010092-uftc8inx 3329 6 some some DT cord-010092-uftc8inx 3329 7 epitopes epitope NNS cord-010092-uftc8inx 3329 8 are be VBP cord-010092-uftc8inx 3329 9 lacking lack VBG cord-010092-uftc8inx 3329 10 and and CC cord-010092-uftc8inx 3329 11 can can MD cord-010092-uftc8inx 3329 12 produce produce VB cord-010092-uftc8inx 3329 13 anti anti JJ cord-010092-uftc8inx 3329 14 - - JJ cord-010092-uftc8inx 3329 15 D d JJ cord-010092-uftc8inx 3329 16 antibody antibody NN cord-010092-uftc8inx 3329 17 , , , cord-010092-uftc8inx 3329 18 are be VBP cord-010092-uftc8inx 3329 19 usually usually RB cord-010092-uftc8inx 3329 20 termed term VBN cord-010092-uftc8inx 3329 21 partial partial JJ cord-010092-uftc8inx 3329 22 D. D. NNP cord-010092-uftc8inx 3330 1 By by IN cord-010092-uftc8inx 3330 2 contrast contrast NN cord-010092-uftc8inx 3330 3 , , , cord-010092-uftc8inx 3330 4 D D NNP cord-010092-uftc8inx 3330 5 weak weak JJ cord-010092-uftc8inx 3330 6 is be VBZ cord-010092-uftc8inx 3330 7 commonly commonly RB cord-010092-uftc8inx 3330 8 defined define VBN cord-010092-uftc8inx 3330 9 as as IN cord-010092-uftc8inx 3330 10 a a DT cord-010092-uftc8inx 3330 11 quantitative quantitative JJ cord-010092-uftc8inx 3330 12 variant variant NN cord-010092-uftc8inx 3330 13 that that WDT cord-010092-uftc8inx 3330 14 have have VBP cord-010092-uftc8inx 3330 15 all all DT cord-010092-uftc8inx 3330 16 D d NN cord-010092-uftc8inx 3330 17 epitopes epitope NNS cord-010092-uftc8inx 3330 18 and and CC cord-010092-uftc8inx 3330 19 should should MD cord-010092-uftc8inx 3330 20 not not RB cord-010092-uftc8inx 3330 21 make make VB cord-010092-uftc8inx 3330 22 anti anti JJ cord-010092-uftc8inx 3330 23 - - JJ cord-010092-uftc8inx 3330 24 D. D. NNP cord-010092-uftc8inx 3330 25 Del Del NNP cord-010092-uftc8inx 3330 26 is be VBZ cord-010092-uftc8inx 3330 27 a a DT cord-010092-uftc8inx 3330 28 very very RB cord-010092-uftc8inx 3330 29 weak weak JJ cord-010092-uftc8inx 3330 30 form form NN cord-010092-uftc8inx 3330 31 of of IN cord-010092-uftc8inx 3330 32 D d NN cord-010092-uftc8inx 3330 33 antigen antigen NN cord-010092-uftc8inx 3330 34 and and CC cord-010092-uftc8inx 3330 35 can can MD cord-010092-uftc8inx 3330 36 not not RB cord-010092-uftc8inx 3330 37 be be VB cord-010092-uftc8inx 3330 38 detected detect VBN cord-010092-uftc8inx 3330 39 by by IN cord-010092-uftc8inx 3330 40 routine routine JJ cord-010092-uftc8inx 3330 41 serological serological JJ cord-010092-uftc8inx 3330 42 tests test NNS cord-010092-uftc8inx 3330 43 . . . cord-010092-uftc8inx 3331 1 Because because IN cord-010092-uftc8inx 3331 2 some some DT cord-010092-uftc8inx 3331 3 of of IN cord-010092-uftc8inx 3331 4 Del Del NNP cord-010092-uftc8inx 3331 5 individuals individual NNS cord-010092-uftc8inx 3331 6 have have VBP cord-010092-uftc8inx 3331 7 already already RB cord-010092-uftc8inx 3331 8 developed develop VBN cord-010092-uftc8inx 3331 9 an an DT cord-010092-uftc8inx 3331 10 anti anti JJ cord-010092-uftc8inx 3331 11 - - JJ cord-010092-uftc8inx 3331 12 D d JJ cord-010092-uftc8inx 3331 13 antibody antibody NN cord-010092-uftc8inx 3331 14 whereas whereas IN cord-010092-uftc8inx 3331 15 others other NNS cord-010092-uftc8inx 3331 16 did do VBD cord-010092-uftc8inx 3331 17 not not RB cord-010092-uftc8inx 3331 18 this this DT cord-010092-uftc8inx 3331 19 group group NN cord-010092-uftc8inx 3331 20 contains contain VBZ cord-010092-uftc8inx 3331 21 both both DT cord-010092-uftc8inx 3331 22 qualitative qualitative JJ cord-010092-uftc8inx 3331 23 and and CC cord-010092-uftc8inx 3331 24 quantitative quantitative JJ cord-010092-uftc8inx 3331 25 changes change NNS cord-010092-uftc8inx 3331 26 . . . cord-010092-uftc8inx 3332 1 Aims aim VBZ cord-010092-uftc8inx 3332 2 : : : cord-010092-uftc8inx 3333 1 Investigation investigation NN cord-010092-uftc8inx 3333 2 was be VBD cord-010092-uftc8inx 3333 3 prompted prompt VBN cord-010092-uftc8inx 3333 4 by by IN cord-010092-uftc8inx 3333 5 finding find VBG cord-010092-uftc8inx 3333 6 discrepant discrepant JJ cord-010092-uftc8inx 3333 7 results result NNS cord-010092-uftc8inx 3333 8 in in IN cord-010092-uftc8inx 3333 9 typing typing NN cord-010092-uftc8inx 3333 10 of of IN cord-010092-uftc8inx 3333 11 D d NN cord-010092-uftc8inx 3333 12 antigen antigen NN cord-010092-uftc8inx 3333 13 in in IN cord-010092-uftc8inx 3333 14 a a DT cord-010092-uftc8inx 3333 15 pregnant pregnant JJ cord-010092-uftc8inx 3333 16 woman woman NN cord-010092-uftc8inx 3333 17 /3 /3 . cord-010092-uftc8inx 3334 1 rd rd NNP cord-010092-uftc8inx 3334 2 pregnancy pregnancy NNP cord-010092-uftc8inx 3334 3 , , , cord-010092-uftc8inx 3334 4 1 1 CD cord-010092-uftc8inx 3334 5 st st NNP cord-010092-uftc8inx 3334 6 delivery delivery NN cord-010092-uftc8inx 3334 7 , , , cord-010092-uftc8inx 3334 8 2 2 CD cord-010092-uftc8inx 3334 9 abortions abortion NNS cord-010092-uftc8inx 3334 10 in in IN cord-010092-uftc8inx 3334 11 1 1 CD cord-010092-uftc8inx 3334 12 st st NNP cord-010092-uftc8inx 3334 13 trimester/. trimester/. NNP cord-010092-uftc8inx 3334 14 Routine routine JJ cord-010092-uftc8inx 3334 15 serological serological JJ cord-010092-uftc8inx 3334 16 techniques technique NNS cord-010092-uftc8inx 3334 17 detected detect VBD cord-010092-uftc8inx 3334 18 D D NNP cord-010092-uftc8inx 3334 19 negativity negativity NN cord-010092-uftc8inx 3334 20 and and CC cord-010092-uftc8inx 3334 21 the the DT cord-010092-uftc8inx 3334 22 presence presence NN cord-010092-uftc8inx 3334 23 of of IN cord-010092-uftc8inx 3334 24 antibody antibody NN cord-010092-uftc8inx 3334 25 allo allo NN cord-010092-uftc8inx 3334 26 - - HYPH cord-010092-uftc8inx 3334 27 anti anti NN cord-010092-uftc8inx 3334 28 - - JJ cord-010092-uftc8inx 3334 29 D d JJ cord-010092-uftc8inx 3334 30 in in IN cord-010092-uftc8inx 3334 31 clinically clinically RB cord-010092-uftc8inx 3334 32 significant significant JJ cord-010092-uftc8inx 3334 33 titre titre NN cord-010092-uftc8inx 3334 34 . . . cord-010092-uftc8inx 3335 1 The the DT cord-010092-uftc8inx 3335 2 non non JJ cord-010092-uftc8inx 3335 3 - - JJ cord-010092-uftc8inx 3335 4 invasive invasive JJ cord-010092-uftc8inx 3335 5 testing testing NN cord-010092-uftc8inx 3335 6 of of IN cord-010092-uftc8inx 3335 7 D d NN cord-010092-uftc8inx 3335 8 status status NN cord-010092-uftc8inx 3335 9 of of IN cord-010092-uftc8inx 3335 10 the the DT cord-010092-uftc8inx 3335 11 foetus foetus NN cord-010092-uftc8inx 3335 12 from from IN cord-010092-uftc8inx 3335 13 maternal maternal JJ cord-010092-uftc8inx 3335 14 peripheral peripheral JJ cord-010092-uftc8inx 3335 15 blood blood NN cord-010092-uftc8inx 3335 16 was be VBD cord-010092-uftc8inx 3335 17 indicated indicate VBN cord-010092-uftc8inx 3335 18 , , , cord-010092-uftc8inx 3335 19 but but CC cord-010092-uftc8inx 3335 20 this this DT cord-010092-uftc8inx 3335 21 was be VBD cord-010092-uftc8inx 3335 22 not not RB cord-010092-uftc8inx 3335 23 applicable applicable JJ cord-010092-uftc8inx 3335 24 due due IN cord-010092-uftc8inx 3335 25 to to IN cord-010092-uftc8inx 3335 26 presence presence NN cord-010092-uftc8inx 3335 27 of of IN cord-010092-uftc8inx 3335 28 the the DT cord-010092-uftc8inx 3335 29 RHD RHD NNP cord-010092-uftc8inx 3335 30 gene gene NN cord-010092-uftc8inx 3335 31 in in IN cord-010092-uftc8inx 3335 32 the the DT cord-010092-uftc8inx 3335 33 woman woman NN cord-010092-uftc8inx 3335 34 's 's POS cord-010092-uftc8inx 3335 35 DNA dna NN cord-010092-uftc8inx 3335 36 sample sample NN cord-010092-uftc8inx 3335 37 isolated isolate VBN cord-010092-uftc8inx 3335 38 from from IN cord-010092-uftc8inx 3335 39 buccal buccal JJ cord-010092-uftc8inx 3335 40 swab swab NN cord-010092-uftc8inx 3335 41 . . . cord-010092-uftc8inx 3336 1 Our -PRON- PRP$ cord-010092-uftc8inx 3336 2 aim aim NN cord-010092-uftc8inx 3336 3 was be VBD cord-010092-uftc8inx 3336 4 to to TO cord-010092-uftc8inx 3336 5 investigate investigate VB cord-010092-uftc8inx 3336 6 the the DT cord-010092-uftc8inx 3336 7 discrepancy discrepancy NN cord-010092-uftc8inx 3336 8 and and CC cord-010092-uftc8inx 3336 9 determine determine VB cord-010092-uftc8inx 3336 10 the the DT cord-010092-uftc8inx 3336 11 underlying underlying JJ cord-010092-uftc8inx 3336 12 RHD RHD NNP cord-010092-uftc8inx 3336 13 genotype genotype NN cord-010092-uftc8inx 3336 14 . . . cord-010092-uftc8inx 3337 1 Methods method NNS cord-010092-uftc8inx 3337 2 : : : cord-010092-uftc8inx 3337 3 Blood blood NN cord-010092-uftc8inx 3337 4 samples sample NNS cord-010092-uftc8inx 3337 5 , , , cord-010092-uftc8inx 3337 6 DNA DNA NNP cord-010092-uftc8inx 3337 7 from from IN cord-010092-uftc8inx 3337 8 peripheral peripheral JJ cord-010092-uftc8inx 3337 9 blood blood NN cord-010092-uftc8inx 3337 10 and and CC cord-010092-uftc8inx 3337 11 buccal buccal JJ cord-010092-uftc8inx 3337 12 swab swab NN cord-010092-uftc8inx 3337 13 of of IN cord-010092-uftc8inx 3337 14 the the DT cord-010092-uftc8inx 3337 15 pregnant pregnant JJ cord-010092-uftc8inx 3337 16 woman woman NN cord-010092-uftc8inx 3337 17 were be VBD cord-010092-uftc8inx 3337 18 investigated investigate VBN cord-010092-uftc8inx 3337 19 . . . cord-010092-uftc8inx 3338 1 Routine routine JJ cord-010092-uftc8inx 3338 2 blood blood NN cord-010092-uftc8inx 3338 3 grouping grouping NN cord-010092-uftc8inx 3338 4 and and CC cord-010092-uftc8inx 3338 5 antibody antibody NN cord-010092-uftc8inx 3338 6 testing testing NN cord-010092-uftc8inx 3338 7 were be VBD cord-010092-uftc8inx 3338 8 performed perform VBN cord-010092-uftc8inx 3338 9 by by IN cord-010092-uftc8inx 3338 10 column column NN cord-010092-uftc8inx 3338 11 agglutination agglutination NN cord-010092-uftc8inx 3338 12 . . . cord-010092-uftc8inx 3339 1 Two two CD cord-010092-uftc8inx 3339 2 anti anti JJ cord-010092-uftc8inx 3339 3 - - JJ cord-010092-uftc8inx 3339 4 D d JJ cord-010092-uftc8inx 3339 5 sera sera FW cord-010092-uftc8inx 3340 1 ( ( -LRB- cord-010092-uftc8inx 3340 2 ID ID NNP cord-010092-uftc8inx 3340 3 - - HYPH cord-010092-uftc8inx 3340 4 DiaClon DiaClon NNP cord-010092-uftc8inx 3340 5 anti anti JJ cord-010092-uftc8inx 3340 6 - - JJ cord-010092-uftc8inx 3340 7 D d JJ cord-010092-uftc8inx 3340 8 IgG igg NN cord-010092-uftc8inx 3340 9 ( ( -LRB- cord-010092-uftc8inx 3340 10 cell cell NN cord-010092-uftc8inx 3340 11 line line NN cord-010092-uftc8inx 3340 12 ESD1 ESD1 NNP cord-010092-uftc8inx 3340 13 ) ) -RRB- cord-010092-uftc8inx 3340 14 by by IN cord-010092-uftc8inx 3340 15 BioRad BioRad NNP cord-010092-uftc8inx 3340 16 and and CC cord-010092-uftc8inx 3340 17 Anti Anti NNP cord-010092-uftc8inx 3340 18 - - JJ cord-010092-uftc8inx 3340 19 D d JJ cord-010092-uftc8inx 3340 20 duo duo NN cord-010092-uftc8inx 3340 21 IgM+IgG igm+igg NN cord-010092-uftc8inx 3340 22 , , , cord-010092-uftc8inx 3340 23 clone clone NN cord-010092-uftc8inx 3340 24 : : : cord-010092-uftc8inx 3341 1 TH28 TH28 NNP cord-010092-uftc8inx 3341 2 + + CC cord-010092-uftc8inx 3341 3 MS26 MS26 NNP cord-010092-uftc8inx 3341 4 by by IN cord-010092-uftc8inx 3341 5 Immucor Immucor NNP cord-010092-uftc8inx 3341 6 ) ) -RRB- cord-010092-uftc8inx 3341 7 were be VBD cord-010092-uftc8inx 3341 8 used use VBN cord-010092-uftc8inx 3341 9 for for IN cord-010092-uftc8inx 3341 10 adsorption adsorption NN cord-010092-uftc8inx 3341 11 / / SYM cord-010092-uftc8inx 3341 12 elution elution NN cord-010092-uftc8inx 3341 13 test test NN cord-010092-uftc8inx 3341 14 for for IN cord-010092-uftc8inx 3341 15 identification identification NN cord-010092-uftc8inx 3341 16 of of IN cord-010092-uftc8inx 3341 17 Del Del NNP cord-010092-uftc8inx 3341 18 phenotype phenotype NN cord-010092-uftc8inx 3341 19 . . . cord-010092-uftc8inx 3342 1 Initial initial JJ cord-010092-uftc8inx 3342 2 RHD RHD NNP cord-010092-uftc8inx 3342 3 genotyping genotyping NN cord-010092-uftc8inx 3342 4 was be VBD cord-010092-uftc8inx 3342 5 performed perform VBN cord-010092-uftc8inx 3342 6 by by IN cord-010092-uftc8inx 3342 7 RT RT NNP cord-010092-uftc8inx 3342 8 - - HYPH cord-010092-uftc8inx 3342 9 PCR PCR NNP cord-010092-uftc8inx 3342 10 ( ( -LRB- cord-010092-uftc8inx 3342 11 exons exon NNS cord-010092-uftc8inx 3342 12 5,7,10 5,7,10 CD cord-010092-uftc8inx 3342 13 ) ) -RRB- cord-010092-uftc8inx 3342 14 with with IN cord-010092-uftc8inx 3342 15 the the DT cord-010092-uftc8inx 3342 16 DNA dna NN cord-010092-uftc8inx 3342 17 from from IN cord-010092-uftc8inx 3342 18 buccal buccal JJ cord-010092-uftc8inx 3342 19 swab swab NN cord-010092-uftc8inx 3342 20 ; ; : cord-010092-uftc8inx 3342 21 further further JJ cord-010092-uftc8inx 3342 22 resolution resolution NN cord-010092-uftc8inx 3342 23 was be VBD cord-010092-uftc8inx 3342 24 performed perform VBN cord-010092-uftc8inx 3342 25 using use VBG cord-010092-uftc8inx 3342 26 PCR PCR NNP cord-010092-uftc8inx 3342 27 - - HYPH cord-010092-uftc8inx 3342 28 SSP SSP NNP cord-010092-uftc8inx 3342 29 ( ( -LRB- cord-010092-uftc8inx 3342 30 FluoGene FluoGene NNP cord-010092-uftc8inx 3342 31 ; ; : cord-010092-uftc8inx 3342 32 Inno inno JJ cord-010092-uftc8inx 3342 33 - - HYPH cord-010092-uftc8inx 3342 34 train train NN cord-010092-uftc8inx 3342 35 Diagnostik Diagnostik NNP cord-010092-uftc8inx 3342 36 GmbH GmbH NNP cord-010092-uftc8inx 3342 37 ) ) -RRB- cord-010092-uftc8inx 3342 38 ; ; : cord-010092-uftc8inx 3342 39 Sequencing Sequencing NNP cord-010092-uftc8inx 3342 40 was be VBD cord-010092-uftc8inx 3342 41 performed perform VBN cord-010092-uftc8inx 3342 42 by by IN cord-010092-uftc8inx 3342 43 Sanger Sanger NNP cord-010092-uftc8inx 3342 44 analysis analysis NN cord-010092-uftc8inx 3342 45 ( ( -LRB- cord-010092-uftc8inx 3342 46 Inno Inno NNP cord-010092-uftc8inx 3342 47 - - HYPH cord-010092-uftc8inx 3342 48 train train NN cord-010092-uftc8inx 3342 49 Diagnostik Diagnostik NNP cord-010092-uftc8inx 3342 50 GmbH GmbH NNP cord-010092-uftc8inx 3342 51 ) ) -RRB- cord-010092-uftc8inx 3342 52 . . . cord-010092-uftc8inx 3343 1 Results result NNS cord-010092-uftc8inx 3343 2 : : : cord-010092-uftc8inx 3344 1 Genotype Genotype NNP cord-010092-uftc8inx 3344 2 was be VBD cord-010092-uftc8inx 3344 3 identified identify VBN cord-010092-uftc8inx 3344 4 as as IN cord-010092-uftc8inx 3344 5 RHD RHD NNP cord-010092-uftc8inx 3344 6 positive positive JJ cord-010092-uftc8inx 3344 7 by by IN cord-010092-uftc8inx 3344 8 CE CE NNP cord-010092-uftc8inx 3344 9 - - HYPH cord-010092-uftc8inx 3344 10 certified certify VBN cord-010092-uftc8inx 3344 11 PCR PCR NNP cord-010092-uftc8inx 3344 12 - - HYPH cord-010092-uftc8inx 3344 13 SSP SSP NNP cord-010092-uftc8inx 3344 14 kits kit NNS cord-010092-uftc8inx 3344 15 ( ( -LRB- cord-010092-uftc8inx 3344 16 FluoGene FluoGene NNP cord-010092-uftc8inx 3344 17 ) ) -RRB- cord-010092-uftc8inx 3344 18 . . . cord-010092-uftc8inx 3345 1 Sanger Sanger NNP cord-010092-uftc8inx 3345 2 sequencing sequencing NN cord-010092-uftc8inx 3345 3 of of IN cord-010092-uftc8inx 3345 4 RHD RHD NNP cord-010092-uftc8inx 3345 5 from from IN cord-010092-uftc8inx 3345 6 exon exon NN cord-010092-uftc8inx 3345 7 1 1 CD cord-010092-uftc8inx 3345 8 to to IN cord-010092-uftc8inx 3345 9 9 9 CD cord-010092-uftc8inx 3345 10 revealed reveal VBN cord-010092-uftc8inx 3345 11 presence presence NN cord-010092-uftc8inx 3345 12 of of IN cord-010092-uftc8inx 3345 13 a a DT cord-010092-uftc8inx 3345 14 nucleotide nucleotide JJ cord-010092-uftc8inx 3345 15 deletion deletion NN cord-010092-uftc8inx 3345 16 in in IN cord-010092-uftc8inx 3345 17 position position NN cord-010092-uftc8inx 3345 18 c.147delA c.147dela CD cord-010092-uftc8inx 3345 19 , , , cord-010092-uftc8inx 3345 20 which which WDT cord-010092-uftc8inx 3345 21 is be VBZ cord-010092-uftc8inx 3345 22 specific specific JJ cord-010092-uftc8inx 3345 23 for for IN cord-010092-uftc8inx 3345 24 allele allele NN cord-010092-uftc8inx 3346 1 RHD*01EL.04 rhd*01el.04 LS cord-010092-uftc8inx 3346 2 . . . cord-010092-uftc8inx 3347 1 This this DT cord-010092-uftc8inx 3347 2 nucleotide nucleotide JJ cord-010092-uftc8inx 3347 3 change change NN cord-010092-uftc8inx 3347 4 results result NNS cord-010092-uftc8inx 3347 5 in in IN cord-010092-uftc8inx 3347 6 the the DT cord-010092-uftc8inx 3347 7 amino amino NN cord-010092-uftc8inx 3347 8 acid acid NN cord-010092-uftc8inx 3347 9 change change NN cord-010092-uftc8inx 3347 10 p. p. NN cord-010092-uftc8inx 3348 1 Val50Leufs*5 Val50Leufs*5 NNP cord-010092-uftc8inx 3348 2 causing cause VBG cord-010092-uftc8inx 3348 3 the the DT cord-010092-uftc8inx 3348 4 Del Del NNP cord-010092-uftc8inx 3348 5 phenotype phenotype NN cord-010092-uftc8inx 3348 6 . . . cord-010092-uftc8inx 3349 1 Presence presence NN cord-010092-uftc8inx 3349 2 of of IN cord-010092-uftc8inx 3349 3 antigen antigen NNP cord-010092-uftc8inx 3349 4 D D NNP cord-010092-uftc8inx 3349 5 was be VBD cord-010092-uftc8inx 3349 6 proved prove VBN cord-010092-uftc8inx 3349 7 by by IN cord-010092-uftc8inx 3349 8 adsorption adsorption NN cord-010092-uftc8inx 3349 9 / / SYM cord-010092-uftc8inx 3349 10 elution elution NN cord-010092-uftc8inx 3349 11 technique technique NN cord-010092-uftc8inx 3349 12 . . . cord-010092-uftc8inx 3350 1 Titre Titre NNP cord-010092-uftc8inx 3350 2 of of IN cord-010092-uftc8inx 3350 3 the the DT cord-010092-uftc8inx 3350 4 anti anti JJ cord-010092-uftc8inx 3350 5 - - NN cord-010092-uftc8inx 3350 6 D d JJ cord-010092-uftc8inx 3350 7 was be VBD cord-010092-uftc8inx 3350 8 rising rise VBG cord-010092-uftc8inx 3350 9 during during IN cord-010092-uftc8inx 3350 10 the the DT cord-010092-uftc8inx 3350 11 pregnancy pregnancy NN cord-010092-uftc8inx 3350 12 to to IN cord-010092-uftc8inx 3350 13 the the DT cord-010092-uftc8inx 3350 14 2000 2000 CD cord-010092-uftc8inx 3350 15 level level NN cord-010092-uftc8inx 3350 16 two two CD cord-010092-uftc8inx 3350 17 weeks week NNS cord-010092-uftc8inx 3350 18 before before IN cord-010092-uftc8inx 3350 19 the the DT cord-010092-uftc8inx 3350 20 delivery delivery NN cord-010092-uftc8inx 3350 21 . . . cord-010092-uftc8inx 3351 1 The the DT cord-010092-uftc8inx 3351 2 newborn newborn NN cord-010092-uftc8inx 3351 3 was be VBD cord-010092-uftc8inx 3351 4 delivered deliver VBN cord-010092-uftc8inx 3351 5 by by IN cord-010092-uftc8inx 3351 6 S.C. South Carolina NNP cord-010092-uftc8inx 3351 7 without without IN cord-010092-uftc8inx 3351 8 a a DT cord-010092-uftc8inx 3351 9 sign sign NN cord-010092-uftc8inx 3351 10 of of IN cord-010092-uftc8inx 3351 11 hemolytic hemolytic JJ cord-010092-uftc8inx 3351 12 disease disease NN cord-010092-uftc8inx 3351 13 . . . cord-010092-uftc8inx 3352 1 Blood blood NN cord-010092-uftc8inx 3352 2 grouping grouping NN cord-010092-uftc8inx 3352 3 of of IN cord-010092-uftc8inx 3352 4 the the DT cord-010092-uftc8inx 3352 5 newborn newborn NN cord-010092-uftc8inx 3352 6 revealed reveal VBD cord-010092-uftc8inx 3352 7 blood blood NN cord-010092-uftc8inx 3352 8 group group NN cord-010092-uftc8inx 3352 9 A A NNP cord-010092-uftc8inx 3352 10 , , , cord-010092-uftc8inx 3352 11 D D NNP cord-010092-uftc8inx 3352 12 negative negative NN cord-010092-uftc8inx 3352 13 , , , cord-010092-uftc8inx 3352 14 DAT DAT NNP cord-010092-uftc8inx 3352 15 negative negative JJ cord-010092-uftc8inx 3352 16 , , , cord-010092-uftc8inx 3352 17 testing test VBG cord-010092-uftc8inx 3352 18 for for IN cord-010092-uftc8inx 3352 19 Del Del NNP cord-010092-uftc8inx 3352 20 was be VBD cord-010092-uftc8inx 3352 21 not not RB cord-010092-uftc8inx 3352 22 performed perform VBN cord-010092-uftc8inx 3352 23 . . . cord-010092-uftc8inx 3353 1 Summary Summary NNP cord-010092-uftc8inx 3353 2 / / SYM cord-010092-uftc8inx 3353 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 3353 4 : : : cord-010092-uftc8inx 3354 1 The the DT cord-010092-uftc8inx 3354 2 case case NN cord-010092-uftc8inx 3354 3 reported report VBD cord-010092-uftc8inx 3354 4 here here RB cord-010092-uftc8inx 3354 5 shows show VBZ cord-010092-uftc8inx 3354 6 that that IN cord-010092-uftc8inx 3354 7 females female NNS cord-010092-uftc8inx 3354 8 with with IN cord-010092-uftc8inx 3354 9 RHD*01EL.04 rhd*01el.04 NN cord-010092-uftc8inx 3354 10 allele allele NN cord-010092-uftc8inx 3354 11 are be VBP cord-010092-uftc8inx 3354 12 able able JJ cord-010092-uftc8inx 3354 13 develop develop VB cord-010092-uftc8inx 3354 14 strong strong JJ cord-010092-uftc8inx 3354 15 anti anti JJ cord-010092-uftc8inx 3354 16 - - JJ cord-010092-uftc8inx 3354 17 D d JJ cord-010092-uftc8inx 3354 18 immunization immunization NN cord-010092-uftc8inx 3354 19 , , , cord-010092-uftc8inx 3354 20 so so CC cord-010092-uftc8inx 3354 21 this this DT cord-010092-uftc8inx 3354 22 type type NN cord-010092-uftc8inx 3354 23 of of IN cord-010092-uftc8inx 3354 24 Del Del NNP cord-010092-uftc8inx 3354 25 phenotype phenotype NN cord-010092-uftc8inx 3354 26 belongs belong VBZ cord-010092-uftc8inx 3354 27 to to IN cord-010092-uftc8inx 3354 28 the the DT cord-010092-uftc8inx 3354 29 " " `` cord-010092-uftc8inx 3354 30 Partial Partial NNP cord-010092-uftc8inx 3354 31 Del Del NNP cord-010092-uftc8inx 3354 32 subgroup subgroup NN cord-010092-uftc8inx 3354 33 " " '' cord-010092-uftc8inx 3354 34 . . . cord-010092-uftc8inx 3355 1 Presence presence NN cord-010092-uftc8inx 3355 2 of of IN cord-010092-uftc8inx 3355 3 variant variant JJ cord-010092-uftc8inx 3355 4 RHD RHD NNP cord-010092-uftc8inx 3355 5 gene gene NN cord-010092-uftc8inx 3355 6 in in IN cord-010092-uftc8inx 3355 7 mother mother NN cord-010092-uftc8inx 3355 8 disabling disable VBG cord-010092-uftc8inx 3355 9 antenatal antenatal JJ cord-010092-uftc8inx 3355 10 fetal fetal JJ cord-010092-uftc8inx 3355 11 genotyping genotyping NN cord-010092-uftc8inx 3355 12 from from IN cord-010092-uftc8inx 3355 13 maternal maternal JJ cord-010092-uftc8inx 3355 14 blood blood NN cord-010092-uftc8inx 3355 15 by by IN cord-010092-uftc8inx 3355 16 current current JJ cord-010092-uftc8inx 3355 17 methods method NNS cord-010092-uftc8inx 3355 18 requires require VBZ cord-010092-uftc8inx 3355 19 a a DT cord-010092-uftc8inx 3355 20 more more RBR cord-010092-uftc8inx 3355 21 attentive attentive JJ cord-010092-uftc8inx 3355 22 approach approach NN cord-010092-uftc8inx 3355 23 to to TO cord-010092-uftc8inx 3355 24 care care VB cord-010092-uftc8inx 3355 25 for for IN cord-010092-uftc8inx 3355 26 such such JJ cord-010092-uftc8inx 3355 27 pregnancies pregnancy NNS cord-010092-uftc8inx 3355 28 . . . cord-010092-uftc8inx 3356 1 Supported support VBN cord-010092-uftc8inx 3356 2 by by IN cord-010092-uftc8inx 3356 3 MH MH NNP cord-010092-uftc8inx 3356 4 CZ CZ NNP cord-010092-uftc8inx 3356 5 - - HYPH cord-010092-uftc8inx 3356 6 DRO DRO NNP cord-010092-uftc8inx 3356 7 UHKT UHKT NNP cord-010092-uftc8inx 3356 8 00023736 00023736 CD cord-010092-uftc8inx 3356 9 and and CC cord-010092-uftc8inx 3356 10 RVO RVO NNP cord-010092-uftc8inx 3356 11 - - HYPH cord-010092-uftc8inx 3356 12 VFN VFN NNP cord-010092-uftc8inx 3356 13 64165 64165 CD cord-010092-uftc8inx 3356 14 . . . cord-010092-uftc8inx 3357 1 5A 5a CD cord-010092-uftc8inx 3357 2 - - HYPH cord-010092-uftc8inx 3357 3 S29 S29 NNP cord-010092-uftc8inx 3357 4 - - HYPH cord-010092-uftc8inx 3357 5 05 05 CD cord-010092-uftc8inx 3358 1 EA EA NNP cord-010092-uftc8inx 3358 2 Scharberg Scharberg NNP cord-010092-uftc8inx 3358 3 1 1 CD cord-010092-uftc8inx 3358 4 , , , cord-010092-uftc8inx 3358 5 S S NNP cord-010092-uftc8inx 3358 6 Rothenberger Rothenberger NNP cord-010092-uftc8inx 3358 7 1 1 CD cord-010092-uftc8inx 3358 8 , , , cord-010092-uftc8inx 3358 9 A a DT cord-010092-uftc8inx 3358 10 St€ St€ NNP cord-010092-uftc8inx 3358 11 urtzel urtzel NN cord-010092-uftc8inx 3358 12 1 1 CD cord-010092-uftc8inx 3358 13 , , , cord-010092-uftc8inx 3358 14 N N NNP cord-010092-uftc8inx 3358 15 Gillhuber Gillhuber NNP cord-010092-uftc8inx 3358 16 1 1 CD cord-010092-uftc8inx 3358 17 , , , cord-010092-uftc8inx 3358 18 S S NNP cord-010092-uftc8inx 3358 19 Seyboth Seyboth NNP cord-010092-uftc8inx 3358 20 1 1 CD cord-010092-uftc8inx 3358 21 , , , cord-010092-uftc8inx 3358 22 E E NNP cord-010092-uftc8inx 3358 23 Richter Richter NNP cord-010092-uftc8inx 3358 24 1 1 CD cord-010092-uftc8inx 3358 25 , , , cord-010092-uftc8inx 3358 26 G G NNP cord-010092-uftc8inx 3358 27 Rink Rink NNP cord-010092-uftc8inx 3358 28 2 2 CD cord-010092-uftc8inx 3358 29 and and CC cord-010092-uftc8inx 3358 30 P p NN cord-010092-uftc8inx 3358 31 Bugert bugert NN cord-010092-uftc8inx 3359 1 2 2 CD cord-010092-uftc8inx 3359 2 1 1 CD cord-010092-uftc8inx 3359 3 Institute Institute NNP cord-010092-uftc8inx 3359 4 for for IN cord-010092-uftc8inx 3359 5 Transfusion Transfusion NNP cord-010092-uftc8inx 3359 6 Medicine Medicine NNP cord-010092-uftc8inx 3359 7 and and CC cord-010092-uftc8inx 3359 8 Immunohematology Immunohematology NNP cord-010092-uftc8inx 3359 9 , , , cord-010092-uftc8inx 3359 10 DRK DRK NNP cord-010092-uftc8inx 3359 11 - - HYPH cord-010092-uftc8inx 3359 12 BSD BSD NNP cord-010092-uftc8inx 3359 13 Ba Ba NNP cord-010092-uftc8inx 3359 14 - - HYPH cord-010092-uftc8inx 3359 15 W€ W€ NNP cord-010092-uftc8inx 3360 1 u u LS cord-010092-uftc8inx 3360 2 - - : cord-010092-uftc8inx 3360 3 He He NNP cord-010092-uftc8inx 3360 4 , , , cord-010092-uftc8inx 3360 5 Baden Baden NNP cord-010092-uftc8inx 3360 6 - - HYPH cord-010092-uftc8inx 3360 7 Baden Baden NNP cord-010092-uftc8inx 3360 8 2 2 CD cord-010092-uftc8inx 3360 9 Institute Institute NNP cord-010092-uftc8inx 3360 10 for for IN cord-010092-uftc8inx 3360 11 Transfusion Transfusion NNP cord-010092-uftc8inx 3360 12 Medicine Medicine NNP cord-010092-uftc8inx 3360 13 and and CC cord-010092-uftc8inx 3360 14 Immunology Immunology NNP cord-010092-uftc8inx 3360 15 , , , cord-010092-uftc8inx 3360 16 Heidelberg Heidelberg NNP cord-010092-uftc8inx 3360 17 University University NNP cord-010092-uftc8inx 3360 18 , , , cord-010092-uftc8inx 3360 19 Medical Medical NNP cord-010092-uftc8inx 3360 20 Faculty Faculty NNP cord-010092-uftc8inx 3360 21 Mannheim Mannheim NNP cord-010092-uftc8inx 3360 22 , , , cord-010092-uftc8inx 3360 23 Mannheim Mannheim NNP cord-010092-uftc8inx 3360 24 , , , cord-010092-uftc8inx 3360 25 Germany Germany NNP cord-010092-uftc8inx 3360 26 Background Background NNP cord-010092-uftc8inx 3360 27 : : : cord-010092-uftc8inx 3360 28 Rb Rb NNP cord-010092-uftc8inx 3360 29 a a DT cord-010092-uftc8inx 3360 30 ( ( -LRB- cord-010092-uftc8inx 3360 31 DI6 DI6 NNP cord-010092-uftc8inx 3360 32 ) ) -RRB- cord-010092-uftc8inx 3360 33 is be VBZ cord-010092-uftc8inx 3360 34 a a DT cord-010092-uftc8inx 3360 35 low low JJ cord-010092-uftc8inx 3360 36 prevalence prevalence NN cord-010092-uftc8inx 3360 37 antigen antigen NN cord-010092-uftc8inx 3360 38 of of IN cord-010092-uftc8inx 3360 39 the the DT cord-010092-uftc8inx 3360 40 Diego Diego NNP cord-010092-uftc8inx 3360 41 blood blood NN cord-010092-uftc8inx 3360 42 group group NN cord-010092-uftc8inx 3360 43 system system NN cord-010092-uftc8inx 3360 44 . . . cord-010092-uftc8inx 3361 1 It -PRON- PRP cord-010092-uftc8inx 3361 2 has have VBZ cord-010092-uftc8inx 3361 3 been be VBN cord-010092-uftc8inx 3361 4 found find VBN cord-010092-uftc8inx 3361 5 in in IN cord-010092-uftc8inx 3361 6 few few JJ cord-010092-uftc8inx 3361 7 families family NNS cord-010092-uftc8inx 3361 8 only only RB cord-010092-uftc8inx 3361 9 . . . cord-010092-uftc8inx 3362 1 The the DT cord-010092-uftc8inx 3362 2 clinical clinical JJ cord-010092-uftc8inx 3362 3 significance significance NN cord-010092-uftc8inx 3362 4 of of IN cord-010092-uftc8inx 3362 5 anti anti JJ cord-010092-uftc8inx 3362 6 - - JJ cord-010092-uftc8inx 3362 7 Rb Rb NNP cord-010092-uftc8inx 3362 8 a a NN cord-010092-uftc8inx 3362 9 is be VBZ cord-010092-uftc8inx 3362 10 unknown unknown JJ cord-010092-uftc8inx 3362 11 so so RB cord-010092-uftc8inx 3362 12 far far RB cord-010092-uftc8inx 3362 13 . . . cord-010092-uftc8inx 3363 1 The the DT cord-010092-uftc8inx 3363 2 SLC4A1*c.1643C SLC4A1*c.1643C NNP cord-010092-uftc8inx 3363 3 > > XX cord-010092-uftc8inx 3364 1 T T NNP cord-010092-uftc8inx 3364 2 ( ( -LRB- cord-010092-uftc8inx 3364 3 p. p. NN cord-010092-uftc8inx 3365 1 Pro548Leu pro548leu CD cord-010092-uftc8inx 3366 1 ; ; : cord-010092-uftc8inx 3366 2 ISBT ISBT NNP cord-010092-uftc8inx 3366 3 allele allele NN cord-010092-uftc8inx 3366 4 name name NN cord-010092-uftc8inx 3366 5 : : : cord-010092-uftc8inx 3367 1 DI*02.06 DI*02.06 NNS cord-010092-uftc8inx 3367 2 ) ) -RRB- cord-010092-uftc8inx 3368 1 allele allele NNP cord-010092-uftc8inx 3368 2 is be VBZ cord-010092-uftc8inx 3368 3 the the DT cord-010092-uftc8inx 3368 4 molecular molecular JJ cord-010092-uftc8inx 3368 5 basis basis NN cord-010092-uftc8inx 3368 6 of of IN cord-010092-uftc8inx 3368 7 the the DT cord-010092-uftc8inx 3368 8 Rb Rb NNP cord-010092-uftc8inx 3368 9 a a DT cord-010092-uftc8inx 3368 10 antigen antigen NN cord-010092-uftc8inx 3368 11 . . . cord-010092-uftc8inx 3369 1 In in IN cord-010092-uftc8inx 3369 2 the the DT cord-010092-uftc8inx 3369 3 gnomAD gnomAD NNP cord-010092-uftc8inx 3369 4 database database NN cord-010092-uftc8inx 3369 5 this this DT cord-010092-uftc8inx 3369 6 gene gene NN cord-010092-uftc8inx 3369 7 variant variant NN cord-010092-uftc8inx 3369 8 was be VBD cord-010092-uftc8inx 3369 9 found find VBN cord-010092-uftc8inx 3369 10 in in IN cord-010092-uftc8inx 3369 11 only only RB cord-010092-uftc8inx 3369 12 one one CD cord-010092-uftc8inx 3369 13 of of IN cord-010092-uftc8inx 3369 14 125,742 125,742 CD cord-010092-uftc8inx 3369 15 sequenced sequence VBN cord-010092-uftc8inx 3369 16 genomes genome NNS cord-010092-uftc8inx 3369 17 ( ( -LRB- cord-010092-uftc8inx 3369 18 allele allele NN cord-010092-uftc8inx 3369 19 frequency frequency NN cord-010092-uftc8inx 3369 20 : : : cord-010092-uftc8inx 3369 21 0.000004 0.000004 CD cord-010092-uftc8inx 3369 22 ) ) -RRB- cord-010092-uftc8inx 3369 23 . . . cord-010092-uftc8inx 3370 1 Aims aim VBZ cord-010092-uftc8inx 3370 2 : : : cord-010092-uftc8inx 3371 1 To to TO cord-010092-uftc8inx 3371 2 prove prove VB cord-010092-uftc8inx 3371 3 the the DT cord-010092-uftc8inx 3371 4 frequency frequency NN cord-010092-uftc8inx 3371 5 of of IN cord-010092-uftc8inx 3371 6 the the DT cord-010092-uftc8inx 3371 7 allele allele NN cord-010092-uftc8inx 3371 8 in in IN cord-010092-uftc8inx 3371 9 our -PRON- PRP$ cord-010092-uftc8inx 3371 10 population population NN cord-010092-uftc8inx 3371 11 and and CC cord-010092-uftc8inx 3371 12 gain gain VB cord-010092-uftc8inx 3371 13 an an DT cord-010092-uftc8inx 3371 14 Rb Rb NNP cord-010092-uftc8inx 3371 15 a a DT cord-010092-uftc8inx 3371 16 positive positive JJ cord-010092-uftc8inx 3371 17 donor donor NN cord-010092-uftc8inx 3371 18 we -PRON- PRP cord-010092-uftc8inx 3371 19 performed perform VBD cord-010092-uftc8inx 3371 20 a a DT cord-010092-uftc8inx 3371 21 molecular molecular JJ cord-010092-uftc8inx 3371 22 screening screening NN cord-010092-uftc8inx 3371 23 for for IN cord-010092-uftc8inx 3371 24 DI6 di6 NN cord-010092-uftc8inx 3371 25 in in IN cord-010092-uftc8inx 3371 26 1,700 1,700 CD cord-010092-uftc8inx 3371 27 blood blood NN cord-010092-uftc8inx 3371 28 donors donor NNS cord-010092-uftc8inx 3371 29 . . . cord-010092-uftc8inx 3372 1 After after IN cord-010092-uftc8inx 3372 2 our -PRON- PRP$ cord-010092-uftc8inx 3372 3 antibody antibody NN cord-010092-uftc8inx 3372 4 screening screening NN cord-010092-uftc8inx 3372 5 test test NN cord-010092-uftc8inx 3372 6 accidentally accidentally RB cord-010092-uftc8inx 3372 7 contained contain VBD cord-010092-uftc8inx 3372 8 an an DT cord-010092-uftc8inx 3372 9 Rb Rb NNP cord-010092-uftc8inx 3372 10 a a DT cord-010092-uftc8inx 3372 11 positive positive JJ cord-010092-uftc8inx 3372 12 test test NN cord-010092-uftc8inx 3372 13 cell cell NN cord-010092-uftc8inx 3372 14 we -PRON- PRP cord-010092-uftc8inx 3372 15 found find VBD cord-010092-uftc8inx 3372 16 out out RP cord-010092-uftc8inx 3372 17 that that IN cord-010092-uftc8inx 3372 18 anti anti JJ cord-010092-uftc8inx 3372 19 - - JJ cord-010092-uftc8inx 3372 20 Rb Rb NNP cord-010092-uftc8inx 3372 21 a a NN cord-010092-uftc8inx 3372 22 is be VBZ cord-010092-uftc8inx 3372 23 a a DT cord-010092-uftc8inx 3372 24 very very RB cord-010092-uftc8inx 3372 25 common common JJ cord-010092-uftc8inx 3372 26 antibody antibody NN cord-010092-uftc8inx 3372 27 specificity specificity NN cord-010092-uftc8inx 3372 28 . . . cord-010092-uftc8inx 3373 1 The the DT cord-010092-uftc8inx 3373 2 frequency frequency NN cord-010092-uftc8inx 3373 3 of of IN cord-010092-uftc8inx 3373 4 the the DT cord-010092-uftc8inx 3373 5 antibody antibody NN cord-010092-uftc8inx 3373 6 in in IN cord-010092-uftc8inx 3373 7 patients patient NNS cord-010092-uftc8inx 3373 8 and and CC cord-010092-uftc8inx 3373 9 blood blood NN cord-010092-uftc8inx 3373 10 donors donor NNS cord-010092-uftc8inx 3373 11 was be VBD cord-010092-uftc8inx 3373 12 proved prove VBN cord-010092-uftc8inx 3373 13 . . . cord-010092-uftc8inx 3374 1 Methods method NNS cord-010092-uftc8inx 3374 2 : : : cord-010092-uftc8inx 3374 3 For for IN cord-010092-uftc8inx 3374 4 the the DT cord-010092-uftc8inx 3374 5 molecular molecular JJ cord-010092-uftc8inx 3374 6 screening screening NN cord-010092-uftc8inx 3374 7 of of IN cord-010092-uftc8inx 3374 8 the the DT cord-010092-uftc8inx 3374 9 blood blood NN cord-010092-uftc8inx 3374 10 donors donor NNS cord-010092-uftc8inx 3374 11 we -PRON- PRP cord-010092-uftc8inx 3374 12 developed develop VBD cord-010092-uftc8inx 3374 13 a a DT cord-010092-uftc8inx 3374 14 PCR PCR NNP cord-010092-uftc8inx 3374 15 - - HYPH cord-010092-uftc8inx 3374 16 SSP SSP NNP cord-010092-uftc8inx 3374 17 method method NN cord-010092-uftc8inx 3374 18 . . . cord-010092-uftc8inx 3375 1 The the DT cord-010092-uftc8inx 3375 2 antibody antibody NN cord-010092-uftc8inx 3375 3 screening screening NN cord-010092-uftc8inx 3375 4 test test NN cord-010092-uftc8inx 3375 5 in in IN cord-010092-uftc8inx 3375 6 3,652 3,652 CD cord-010092-uftc8inx 3375 7 patients patient NNS cord-010092-uftc8inx 3375 8 and and CC cord-010092-uftc8inx 3375 9 in in IN cord-010092-uftc8inx 3375 10 964 964 CD cord-010092-uftc8inx 3375 11 blood blood NN cord-010092-uftc8inx 3375 12 donors donor NNS cord-010092-uftc8inx 3375 13 was be VBD cord-010092-uftc8inx 3375 14 performed perform VBN cord-010092-uftc8inx 3375 15 in in IN cord-010092-uftc8inx 3375 16 the the DT cord-010092-uftc8inx 3375 17 gel gel NN cord-010092-uftc8inx 3375 18 technique technique NN cord-010092-uftc8inx 3375 19 ( ( -LRB- cord-010092-uftc8inx 3375 20 BioRad BioRad NNP cord-010092-uftc8inx 3375 21 AHG AHG NNP cord-010092-uftc8inx 3375 22 ID ID NNP cord-010092-uftc8inx 3375 23 - - HYPH cord-010092-uftc8inx 3375 24 Cards Cards NNP cord-010092-uftc8inx 3375 25 ) ) -RRB- cord-010092-uftc8inx 3375 26 using use VBG cord-010092-uftc8inx 3375 27 a a DT cord-010092-uftc8inx 3375 28 3 3 CD cord-010092-uftc8inx 3375 29 cell cell NN cord-010092-uftc8inx 3375 30 screening screening NN cord-010092-uftc8inx 3375 31 panel panel NN cord-010092-uftc8inx 3375 32 ( ( -LRB- cord-010092-uftc8inx 3375 33 DRK DRK NNP cord-010092-uftc8inx 3375 34 - - HYPH cord-010092-uftc8inx 3375 35 BSD BSD NNP cord-010092-uftc8inx 3375 36 SRC SRC NNP cord-010092-uftc8inx 3375 37 ) ) -RRB- cord-010092-uftc8inx 3375 38 including include VBG cord-010092-uftc8inx 3375 39 an an DT cord-010092-uftc8inx 3375 40 Rb Rb NNP cord-010092-uftc8inx 3375 41 a a DT cord-010092-uftc8inx 3375 42 positive positive JJ cord-010092-uftc8inx 3375 43 test test NN cord-010092-uftc8inx 3375 44 cell cell NN cord-010092-uftc8inx 3375 45 . . . cord-010092-uftc8inx 3376 1 Positive positive JJ cord-010092-uftc8inx 3376 2 reactions reaction NNS cord-010092-uftc8inx 3376 3 with with IN cord-010092-uftc8inx 3376 4 the the DT cord-010092-uftc8inx 3376 5 Rb Rb NNP cord-010092-uftc8inx 3376 6 a a DT cord-010092-uftc8inx 3376 7 positive positive JJ cord-010092-uftc8inx 3376 8 cell cell NN cord-010092-uftc8inx 3376 9 were be VBD cord-010092-uftc8inx 3376 10 confirmed confirm VBN cord-010092-uftc8inx 3376 11 by by IN cord-010092-uftc8inx 3376 12 an an DT cord-010092-uftc8inx 3376 13 additional additional JJ cord-010092-uftc8inx 3376 14 Rb Rb NNS cord-010092-uftc8inx 3376 15 a a DT cord-010092-uftc8inx 3376 16 positive positive JJ cord-010092-uftc8inx 3376 17 test test NN cord-010092-uftc8inx 3376 18 cell cell NN cord-010092-uftc8inx 3376 19 of of IN cord-010092-uftc8inx 3376 20 different different JJ cord-010092-uftc8inx 3376 21 source source NN cord-010092-uftc8inx 3376 22 . . . cord-010092-uftc8inx 3377 1 Additional additional JJ cord-010092-uftc8inx 3377 2 antibodies antibody NNS cord-010092-uftc8inx 3377 3 were be VBD cord-010092-uftc8inx 3377 4 excluded exclude VBN cord-010092-uftc8inx 3377 5 or or CC cord-010092-uftc8inx 3377 6 identified identify VBN cord-010092-uftc8inx 3377 7 in in IN cord-010092-uftc8inx 3377 8 the the DT cord-010092-uftc8inx 3377 9 same same JJ cord-010092-uftc8inx 3377 10 method method NN cord-010092-uftc8inx 3377 11 using use VBG cord-010092-uftc8inx 3377 12 an an DT cord-010092-uftc8inx 3377 13 antibody antibody NN cord-010092-uftc8inx 3377 14 identification identification NN cord-010092-uftc8inx 3377 15 panel panel NN cord-010092-uftc8inx 3377 16 ( ( -LRB- cord-010092-uftc8inx 3377 17 DRK DRK NNP cord-010092-uftc8inx 3377 18 - - HYPH cord-010092-uftc8inx 3377 19 BSD BSD NNP cord-010092-uftc8inx 3377 20 IRC IRC NNP cord-010092-uftc8inx 3377 21 ) ) -RRB- cord-010092-uftc8inx 3377 22 . . . cord-010092-uftc8inx 3378 1 Results result NNS cord-010092-uftc8inx 3378 2 : : : cord-010092-uftc8inx 3379 1 The the DT cord-010092-uftc8inx 3379 2 molecular molecular JJ cord-010092-uftc8inx 3379 3 screening screening NN cord-010092-uftc8inx 3379 4 for for IN cord-010092-uftc8inx 3379 5 the the DT cord-010092-uftc8inx 3379 6 DI*02.06 DI*02.06 NNP cord-010092-uftc8inx 3379 7 allele allele NN cord-010092-uftc8inx 3379 8 in in IN cord-010092-uftc8inx 3379 9 1,700 1,700 CD cord-010092-uftc8inx 3379 10 blood blood NN cord-010092-uftc8inx 3379 11 donors donor NNS cord-010092-uftc8inx 3379 12 revealed reveal VBD cord-010092-uftc8inx 3379 13 no no DT cord-010092-uftc8inx 3379 14 single single JJ cord-010092-uftc8inx 3379 15 positive positive JJ cord-010092-uftc8inx 3379 16 individual individual NN cord-010092-uftc8inx 3379 17 . . . cord-010092-uftc8inx 3380 1 Within within IN cord-010092-uftc8inx 3380 2 the the DT cord-010092-uftc8inx 3380 3 first first JJ cord-010092-uftc8inx 3380 4 2 2 CD cord-010092-uftc8inx 3380 5 weeks week NNS cord-010092-uftc8inx 3380 6 of of IN cord-010092-uftc8inx 3380 7 usage usage NN cord-010092-uftc8inx 3380 8 of of IN cord-010092-uftc8inx 3380 9 our -PRON- PRP$ cord-010092-uftc8inx 3380 10 antibody antibody NN cord-010092-uftc8inx 3380 11 screening screening NN cord-010092-uftc8inx 3380 12 test test NN cord-010092-uftc8inx 3380 13 which which WDT cord-010092-uftc8inx 3380 14 accidentally accidentally RB cord-010092-uftc8inx 3380 15 contained contain VBD cord-010092-uftc8inx 3380 16 the the DT cord-010092-uftc8inx 3380 17 Rb Rb NNP cord-010092-uftc8inx 3380 18 a a DT cord-010092-uftc8inx 3380 19 positive positive JJ cord-010092-uftc8inx 3380 20 test test NN cord-010092-uftc8inx 3380 21 cell cell NN cord-010092-uftc8inx 3380 22 84 84 CD cord-010092-uftc8inx 3380 23 patients patient NNS cord-010092-uftc8inx 3380 24 with with IN cord-010092-uftc8inx 3380 25 anti anti JJ cord-010092-uftc8inx 3380 26 - - JJ cord-010092-uftc8inx 3380 27 Rb Rb NNP cord-010092-uftc8inx 3380 28 a a DT cord-010092-uftc8inx 3380 29 were be VBD cord-010092-uftc8inx 3380 30 found find VBN cord-010092-uftc8inx 3380 31 . . . cord-010092-uftc8inx 3381 1 It -PRON- PRP cord-010092-uftc8inx 3381 2 was be VBD cord-010092-uftc8inx 3381 3 2.3 2.3 CD cord-010092-uftc8inx 3381 4 % % NN cord-010092-uftc8inx 3381 5 of of IN cord-010092-uftc8inx 3381 6 3,652 3,652 CD cord-010092-uftc8inx 3381 7 patients patient NNS cord-010092-uftc8inx 3381 8 tested test VBN cord-010092-uftc8inx 3381 9 in in IN cord-010092-uftc8inx 3381 10 21 21 CD cord-010092-uftc8inx 3381 11 laboratories laboratory NNS cord-010092-uftc8inx 3381 12 in in IN cord-010092-uftc8inx 3381 13 different different JJ cord-010092-uftc8inx 3381 14 parts part NNS cord-010092-uftc8inx 3381 15 of of IN cord-010092-uftc8inx 3381 16 Germany Germany NNP cord-010092-uftc8inx 3381 17 . . . cord-010092-uftc8inx 3382 1 Some some DT cord-010092-uftc8inx 3382 2 laboratories laboratory NNS cord-010092-uftc8inx 3382 3 stopped stop VBD cord-010092-uftc8inx 3382 4 using use VBG cord-010092-uftc8inx 3382 5 the the DT cord-010092-uftc8inx 3382 6 Rb Rb NNP cord-010092-uftc8inx 3382 7 a a DT cord-010092-uftc8inx 3382 8 positive positive JJ cord-010092-uftc8inx 3382 9 lot lot NN cord-010092-uftc8inx 3382 10 to to TO cord-010092-uftc8inx 3382 11 avoid avoid VB cord-010092-uftc8inx 3382 12 expensive expensive JJ cord-010092-uftc8inx 3382 13 and and CC cord-010092-uftc8inx 3382 14 time time NN cord-010092-uftc8inx 3382 15 consuming consume VBG cord-010092-uftc8inx 3382 16 identification identification NN cord-010092-uftc8inx 3382 17 and and CC cord-010092-uftc8inx 3382 18 conformation conformation NN cord-010092-uftc8inx 3382 19 tests test NNS cord-010092-uftc8inx 3382 20 . . . cord-010092-uftc8inx 3383 1 In in IN cord-010092-uftc8inx 3383 2 18 18 CD cord-010092-uftc8inx 3383 3 of of IN cord-010092-uftc8inx 3383 4 964 964 CD cord-010092-uftc8inx 3383 5 randomly randomly RB cord-010092-uftc8inx 3383 6 tested test VBD cord-010092-uftc8inx 3383 7 blood blood NN cord-010092-uftc8inx 3383 8 donors donor NNS cord-010092-uftc8inx 3383 9 ( ( -LRB- cord-010092-uftc8inx 3383 10 1.9 1.9 CD cord-010092-uftc8inx 3383 11 % % NN cord-010092-uftc8inx 3383 12 ) ) -RRB- cord-010092-uftc8inx 3383 13 anti anti JJ cord-010092-uftc8inx 3383 14 - - JJ cord-010092-uftc8inx 3383 15 anti anti JJ cord-010092-uftc8inx 3383 16 - - JJ cord-010092-uftc8inx 3383 17 Rb Rb NNP cord-010092-uftc8inx 3383 18 a a DT cord-010092-uftc8inx 3383 19 was be VBD cord-010092-uftc8inx 3383 20 also also RB cord-010092-uftc8inx 3383 21 present present JJ cord-010092-uftc8inx 3383 22 . . . cord-010092-uftc8inx 3384 1 Summary Summary NNP cord-010092-uftc8inx 3384 2 / / SYM cord-010092-uftc8inx 3384 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 3384 4 : : : cord-010092-uftc8inx 3385 1 Despite despite IN cord-010092-uftc8inx 3385 2 the the DT cord-010092-uftc8inx 3385 3 very very RB cord-010092-uftc8inx 3385 4 low low JJ cord-010092-uftc8inx 3385 5 frequency frequency NN cord-010092-uftc8inx 3385 6 of of IN cord-010092-uftc8inx 3385 7 the the DT cord-010092-uftc8inx 3385 8 DI*02.06 DI*02.06 NNP cord-010092-uftc8inx 3385 9 allele allele NN cord-010092-uftc8inx 3385 10 , , , cord-010092-uftc8inx 3385 11 anti anti NNP cord-010092-uftc8inx 3385 12 - - NNP cord-010092-uftc8inx 3385 13 Rb Rb NNP cord-010092-uftc8inx 3385 14 a a NN cord-010092-uftc8inx 3385 15 is be VBZ cord-010092-uftc8inx 3385 16 a a DT cord-010092-uftc8inx 3385 17 very very RB cord-010092-uftc8inx 3385 18 frequent frequent JJ cord-010092-uftc8inx 3385 19 unexpected unexpected JJ cord-010092-uftc8inx 3385 20 antibody antibody NN cord-010092-uftc8inx 3385 21 in in IN cord-010092-uftc8inx 3385 22 patients patient NNS cord-010092-uftc8inx 3385 23 and and CC cord-010092-uftc8inx 3385 24 blood blood NN cord-010092-uftc8inx 3385 25 donors donor NNS cord-010092-uftc8inx 3385 26 in in IN cord-010092-uftc8inx 3385 27 Germany Germany NNP cord-010092-uftc8inx 3385 28 . . . cord-010092-uftc8inx 3386 1 It -PRON- PRP cord-010092-uftc8inx 3386 2 is be VBZ cord-010092-uftc8inx 3386 3 obviously obviously RB cord-010092-uftc8inx 3386 4 naturally naturally RB cord-010092-uftc8inx 3386 5 occurring occur VBG cord-010092-uftc8inx 3386 6 and and CC cord-010092-uftc8inx 3386 7 is be VBZ cord-010092-uftc8inx 3386 8 even even RB cord-010092-uftc8inx 3386 9 more more RBR cord-010092-uftc8inx 3386 10 frequent frequent JJ cord-010092-uftc8inx 3386 11 than than IN cord-010092-uftc8inx 3386 12 anti anti JJ cord-010092-uftc8inx 3386 13 - - JJ cord-010092-uftc8inx 3386 14 Wr Wr NNP cord-010092-uftc8inx 3386 15 a a DT cord-010092-uftc8inx 3387 1 and and CC cord-010092-uftc8inx 3387 2 anti anti JJ cord-010092-uftc8inx 3387 3 - - JJ cord-010092-uftc8inx 3387 4 Vw Vw NNP cord-010092-uftc8inx 3387 5 we -PRON- PRP cord-010092-uftc8inx 3387 6 found find VBD cord-010092-uftc8inx 3387 7 in in IN cord-010092-uftc8inx 3387 8 previous previous JJ cord-010092-uftc8inx 3387 9 studies study NNS cord-010092-uftc8inx 3387 10 in in IN cord-010092-uftc8inx 3387 11 around around IN cord-010092-uftc8inx 3387 12 1 1 CD cord-010092-uftc8inx 3387 13 % % NN cord-010092-uftc8inx 3387 14 of of IN cord-010092-uftc8inx 3387 15 patients patient NNS cord-010092-uftc8inx 3387 16 and and CC cord-010092-uftc8inx 3387 17 donors donor NNS cord-010092-uftc8inx 3387 18 . . . cord-010092-uftc8inx 3388 1 5A 5a CD cord-010092-uftc8inx 3388 2 - - HYPH cord-010092-uftc8inx 3388 3 S30 S30 NNP cord-010092-uftc8inx 3388 4 - - HYPH cord-010092-uftc8inx 3388 5 01 01 CD cord-010092-uftc8inx 3388 6 National National NNP cord-010092-uftc8inx 3388 7 Blood Blood NNP cord-010092-uftc8inx 3388 8 Center Center NNP cord-010092-uftc8inx 3388 9 , , , cord-010092-uftc8inx 3388 10 Ministry Ministry NNP cord-010092-uftc8inx 3388 11 of of IN cord-010092-uftc8inx 3388 12 Health Health NNP cord-010092-uftc8inx 3388 13 and and CC cord-010092-uftc8inx 3388 14 Sports Sports NNPS cord-010092-uftc8inx 3388 15 , , , cord-010092-uftc8inx 3388 16 Yangon Yangon NNP cord-010092-uftc8inx 3388 17 , , , cord-010092-uftc8inx 3388 18 Myanmar Myanmar NNP cord-010092-uftc8inx 3388 19 Hemovigilance Hemovigilance NNP cord-010092-uftc8inx 3388 20 which which WDT cord-010092-uftc8inx 3388 21 detects detect VBZ cord-010092-uftc8inx 3388 22 every every DT cord-010092-uftc8inx 3388 23 event event NN cord-010092-uftc8inx 3388 24 not not RB cord-010092-uftc8inx 3388 25 only only RB cord-010092-uftc8inx 3388 26 for for IN cord-010092-uftc8inx 3388 27 patient patient NN cord-010092-uftc8inx 3388 28 ' ' '' cord-010092-uftc8inx 3388 29 reactions reaction NNS cord-010092-uftc8inx 3388 30 and and CC cord-010092-uftc8inx 3388 31 donor donor NN cord-010092-uftc8inx 3388 32 's 's POS cord-010092-uftc8inx 3388 33 complications complication NNS cord-010092-uftc8inx 3388 34 but but CC cord-010092-uftc8inx 3388 35 also also RB cord-010092-uftc8inx 3388 36 incidents incident NNS cord-010092-uftc8inx 3388 37 and and CC cord-010092-uftc8inx 3388 38 near near JJ cord-010092-uftc8inx 3388 39 misses miss NNS cord-010092-uftc8inx 3388 40 definitely definitely RB cord-010092-uftc8inx 3388 41 improve improve VB cord-010092-uftc8inx 3388 42 quality quality NN cord-010092-uftc8inx 3388 43 of of IN cord-010092-uftc8inx 3388 44 blood blood NN cord-010092-uftc8inx 3388 45 transfusion transfusion NN cord-010092-uftc8inx 3388 46 services service NNS cord-010092-uftc8inx 3388 47 especially especially RB cord-010092-uftc8inx 3388 48 for for IN cord-010092-uftc8inx 3388 49 those those DT cord-010092-uftc8inx 3388 50 situations situation NNS cord-010092-uftc8inx 3388 51 where where WRB cord-010092-uftc8inx 3388 52 implementation implementation NN cord-010092-uftc8inx 3388 53 of of IN cord-010092-uftc8inx 3388 54 all all PDT cord-010092-uftc8inx 3388 55 the the DT cord-010092-uftc8inx 3388 56 standards standard NNS cord-010092-uftc8inx 3388 57 in in IN cord-010092-uftc8inx 3388 58 one one CD cord-010092-uftc8inx 3388 59 time time NN cord-010092-uftc8inx 3388 60 is be VBZ cord-010092-uftc8inx 3388 61 not not RB cord-010092-uftc8inx 3388 62 possible possible JJ cord-010092-uftc8inx 3388 63 . . . cord-010092-uftc8inx 3389 1 Healthcare healthcare NN cord-010092-uftc8inx 3389 2 system system NN cord-010092-uftc8inx 3389 3 in in IN cord-010092-uftc8inx 3389 4 Myanmar Myanmar NNP cord-010092-uftc8inx 3389 5 is be VBZ cord-010092-uftc8inx 3389 6 still still RB cord-010092-uftc8inx 3389 7 in in IN cord-010092-uftc8inx 3389 8 the the DT cord-010092-uftc8inx 3389 9 stage stage NN cord-010092-uftc8inx 3389 10 of of IN cord-010092-uftc8inx 3389 11 requiring require VBG cord-010092-uftc8inx 3389 12 priority priority NN cord-010092-uftc8inx 3389 13 for for IN cord-010092-uftc8inx 3389 14 clinical clinical JJ cord-010092-uftc8inx 3389 15 professions profession NNS cord-010092-uftc8inx 3389 16 and and CC cord-010092-uftc8inx 3389 17 has have VBZ cord-010092-uftc8inx 3389 18 limited limit VBN cord-010092-uftc8inx 3389 19 resources resource NNS cord-010092-uftc8inx 3389 20 for for IN cord-010092-uftc8inx 3389 21 supportive supportive JJ cord-010092-uftc8inx 3389 22 roles role NNS cord-010092-uftc8inx 3389 23 . . . cord-010092-uftc8inx 3390 1 Supportive supportive JJ cord-010092-uftc8inx 3390 2 services service NNS cord-010092-uftc8inx 3390 3 including include VBG cord-010092-uftc8inx 3390 4 transfusion transfusion NN cord-010092-uftc8inx 3390 5 service service NN cord-010092-uftc8inx 3390 6 are be VBP cord-010092-uftc8inx 3390 7 still still RB cord-010092-uftc8inx 3390 8 not not RB cord-010092-uftc8inx 3390 9 a a DT cord-010092-uftc8inx 3390 10 center center NN cord-010092-uftc8inx 3390 11 of of IN cord-010092-uftc8inx 3390 12 interest interest NN cord-010092-uftc8inx 3390 13 from from IN cord-010092-uftc8inx 3390 14 prioritization prioritization NN cord-010092-uftc8inx 3390 15 of of IN cord-010092-uftc8inx 3390 16 health health NN cord-010092-uftc8inx 3390 17 care care NN cord-010092-uftc8inx 3390 18 system system NN cord-010092-uftc8inx 3390 19 . . . cord-010092-uftc8inx 3391 1 Blood Blood NNP cord-010092-uftc8inx 3391 2 Transfusion Transfusion NNP cord-010092-uftc8inx 3391 3 service service NN cord-010092-uftc8inx 3391 4 has have VBZ cord-010092-uftc8inx 3391 5 been be VBN cord-010092-uftc8inx 3391 6 practiced practice VBN cord-010092-uftc8inx 3391 7 in in IN cord-010092-uftc8inx 3391 8 Myanmar Myanmar NNP cord-010092-uftc8inx 3391 9 since since IN cord-010092-uftc8inx 3391 10 1935 1935 CD cord-010092-uftc8inx 3391 11 . . . cord-010092-uftc8inx 3392 1 Real real JJ cord-010092-uftc8inx 3392 2 essence essence NN cord-010092-uftc8inx 3392 3 of of IN cord-010092-uftc8inx 3392 4 transfusion transfusion NN cord-010092-uftc8inx 3392 5 service service NN cord-010092-uftc8inx 3392 6 is be VBZ cord-010092-uftc8inx 3392 7 hidden hide VBN cord-010092-uftc8inx 3392 8 behind behind IN cord-010092-uftc8inx 3392 9 laboratory laboratory NN cord-010092-uftc8inx 3392 10 practice practice NN cord-010092-uftc8inx 3392 11 and and CC cord-010092-uftc8inx 3392 12 transfusion transfusion NN cord-010092-uftc8inx 3392 13 is be VBZ cord-010092-uftc8inx 3392 14 regarded regard VBN cord-010092-uftc8inx 3392 15 as as IN cord-010092-uftc8inx 3392 16 part part NN cord-010092-uftc8inx 3392 17 of of IN cord-010092-uftc8inx 3392 18 laboratory laboratory NN cord-010092-uftc8inx 3392 19 investigation investigation NN cord-010092-uftc8inx 3392 20 . . . cord-010092-uftc8inx 3393 1 Hospital hospital NN cord-010092-uftc8inx 3393 2 laboratories laboratory NNS cord-010092-uftc8inx 3393 3 take take VBP cord-010092-uftc8inx 3393 4 care care NN cord-010092-uftc8inx 3393 5 of of IN cord-010092-uftc8inx 3393 6 testing testing NN cord-010092-uftc8inx 3393 7 of of IN cord-010092-uftc8inx 3393 8 blood blood NN cord-010092-uftc8inx 3393 9 donated donate VBN cord-010092-uftc8inx 3393 10 by by IN cord-010092-uftc8inx 3393 11 replacement replacement NN cord-010092-uftc8inx 3393 12 donors donor NNS cord-010092-uftc8inx 3393 13 . . . cord-010092-uftc8inx 3394 1 This this DT cord-010092-uftc8inx 3394 2 kind kind NN cord-010092-uftc8inx 3394 3 of of IN cord-010092-uftc8inx 3394 4 transfusion transfusion NN cord-010092-uftc8inx 3394 5 services service NNS cord-010092-uftc8inx 3394 6 under under IN cord-010092-uftc8inx 3394 7 laboratory laboratory NN cord-010092-uftc8inx 3394 8 umbrella umbrella NN cord-010092-uftc8inx 3394 9 is be VBZ cord-010092-uftc8inx 3394 10 still still RB cord-010092-uftc8inx 3394 11 being be VBG cord-010092-uftc8inx 3394 12 practiced practice VBN cord-010092-uftc8inx 3394 13 in in IN cord-010092-uftc8inx 3394 14 Myanmar Myanmar NNP cord-010092-uftc8inx 3394 15 except except IN cord-010092-uftc8inx 3394 16 National National NNP cord-010092-uftc8inx 3394 17 Blood Blood NNP cord-010092-uftc8inx 3394 18 center center NN cord-010092-uftc8inx 3394 19 ( ( -LRB- cord-010092-uftc8inx 3394 20 NBC NBC NNP cord-010092-uftc8inx 3394 21 ) ) -RRB- cord-010092-uftc8inx 3394 22 which which WDT cord-010092-uftc8inx 3394 23 was be VBD cord-010092-uftc8inx 3394 24 established establish VBN cord-010092-uftc8inx 3394 25 in in IN cord-010092-uftc8inx 3394 26 2003 2003 CD cord-010092-uftc8inx 3394 27 in in IN cord-010092-uftc8inx 3394 28 accordance accordance NN cord-010092-uftc8inx 3394 29 with with IN cord-010092-uftc8inx 3394 30 Blood blood NN cord-010092-uftc8inx 3394 31 and and CC cord-010092-uftc8inx 3394 32 Blood Blood NNP cord-010092-uftc8inx 3394 33 Product Product NNP cord-010092-uftc8inx 3394 34 law law NN cord-010092-uftc8inx 3394 35 . . . cord-010092-uftc8inx 3395 1 This this DT cord-010092-uftc8inx 3395 2 Law Law NNP cord-010092-uftc8inx 3395 3 was be VBD cord-010092-uftc8inx 3395 4 formulated formulate VBN cord-010092-uftc8inx 3395 5 cohesively cohesively RB cord-010092-uftc8inx 3395 6 with with IN cord-010092-uftc8inx 3395 7 WHO WHO NNP cord-010092-uftc8inx 3395 8 strategies strategy NNS cord-010092-uftc8inx 3395 9 of of IN cord-010092-uftc8inx 3395 10 blood blood NN cord-010092-uftc8inx 3395 11 safety safety NN cord-010092-uftc8inx 3395 12 . . . cord-010092-uftc8inx 3396 1 In in IN cord-010092-uftc8inx 3396 2 2002 2002 CD cord-010092-uftc8inx 3396 3 , , , cord-010092-uftc8inx 3396 4 WHO who WP cord-010092-uftc8inx 3396 5 global global JJ cord-010092-uftc8inx 3396 6 data data NN cord-010092-uftc8inx 3396 7 - - HYPH cord-010092-uftc8inx 3396 8 based base VBN cord-010092-uftc8inx 3396 9 study study NN cord-010092-uftc8inx 3396 10 sent send VBD cord-010092-uftc8inx 3396 11 questionnaires questionnaire NNS cord-010092-uftc8inx 3396 12 for for IN cord-010092-uftc8inx 3396 13 assessment assessment NN cord-010092-uftc8inx 3396 14 of of IN cord-010092-uftc8inx 3396 15 safety safety NN cord-010092-uftc8inx 3396 16 status status NN cord-010092-uftc8inx 3396 17 of of IN cord-010092-uftc8inx 3396 18 transfusion transfusion NN cord-010092-uftc8inx 3396 19 service service NN cord-010092-uftc8inx 3396 20 . . . cord-010092-uftc8inx 3397 1 NBC NBC NNP cord-010092-uftc8inx 3397 2 noticed notice VBD cord-010092-uftc8inx 3397 3 that that IN cord-010092-uftc8inx 3397 4 there there EX cord-010092-uftc8inx 3397 5 was be VBD cord-010092-uftc8inx 3397 6 no no DT cord-010092-uftc8inx 3397 7 data data NN cord-010092-uftc8inx 3397 8 which which WDT cord-010092-uftc8inx 3397 9 can can MD cord-010092-uftc8inx 3397 10 support support VB cord-010092-uftc8inx 3397 11 corrective corrective JJ cord-010092-uftc8inx 3397 12 actions action NNS cord-010092-uftc8inx 3397 13 for for IN cord-010092-uftc8inx 3397 14 safety safety NN cord-010092-uftc8inx 3397 15 . . . cord-010092-uftc8inx 3398 1 From from IN cord-010092-uftc8inx 3398 2 that that DT cord-010092-uftc8inx 3398 3 time time NN cord-010092-uftc8inx 3398 4 onward onward RB cord-010092-uftc8inx 3398 5 , , , cord-010092-uftc8inx 3398 6 active active JJ cord-010092-uftc8inx 3398 7 retrospective retrospective JJ cord-010092-uftc8inx 3398 8 review review NN cord-010092-uftc8inx 3398 9 of of IN cord-010092-uftc8inx 3398 10 existing exist VBG cord-010092-uftc8inx 3398 11 data datum NNS cord-010092-uftc8inx 3398 12 and and CC cord-010092-uftc8inx 3398 13 introduction introduction NN cord-010092-uftc8inx 3398 14 of of IN cord-010092-uftc8inx 3398 15 records record NNS cord-010092-uftc8inx 3398 16 , , , cord-010092-uftc8inx 3398 17 prospective prospective JJ cord-010092-uftc8inx 3398 18 finding finding NN cord-010092-uftc8inx 3398 19 of of IN cord-010092-uftc8inx 3398 20 process process NN cord-010092-uftc8inx 3398 21 errors error NNS cord-010092-uftc8inx 3398 22 and and CC cord-010092-uftc8inx 3398 23 any any DT cord-010092-uftc8inx 3398 24 events event NNS cord-010092-uftc8inx 3398 25 from from IN cord-010092-uftc8inx 3398 26 hospital hospital NN cord-010092-uftc8inx 3398 27 blood blood NN cord-010092-uftc8inx 3398 28 banks bank NNS cord-010092-uftc8inx 3398 29 were be VBD cord-010092-uftc8inx 3398 30 recorded record VBN cord-010092-uftc8inx 3398 31 and and CC cord-010092-uftc8inx 3398 32 taking take VBG cord-010092-uftc8inx 3398 33 into into IN cord-010092-uftc8inx 3398 34 actions action NNS cord-010092-uftc8inx 3398 35 at at IN cord-010092-uftc8inx 3398 36 local local JJ cord-010092-uftc8inx 3398 37 level level NN cord-010092-uftc8inx 3398 38 . . . cord-010092-uftc8inx 3399 1 Cost cost NN cord-010092-uftc8inx 3399 2 of of IN cord-010092-uftc8inx 3399 3 every every DT cord-010092-uftc8inx 3399 4 unit unit NN cord-010092-uftc8inx 3399 5 of of IN cord-010092-uftc8inx 3399 6 blood blood NN cord-010092-uftc8inx 3399 7 is be VBZ cord-010092-uftc8inx 3399 8 supported support VBN cord-010092-uftc8inx 3399 9 by by IN cord-010092-uftc8inx 3399 10 Government Government NNP cord-010092-uftc8inx 3399 11 . . . cord-010092-uftc8inx 3400 1 In in IN cord-010092-uftc8inx 3400 2 2017 2017 CD cord-010092-uftc8inx 3400 3 , , , cord-010092-uftc8inx 3400 4 National national JJ cord-010092-uftc8inx 3400 5 blood blood NN cord-010092-uftc8inx 3400 6 and and CC cord-010092-uftc8inx 3400 7 Blood Blood NNP cord-010092-uftc8inx 3400 8 Product Product NNP cord-010092-uftc8inx 3400 9 committee committee NN cord-010092-uftc8inx 3400 10 was be VBD cord-010092-uftc8inx 3400 11 established establish VBN cord-010092-uftc8inx 3400 12 . . . cord-010092-uftc8inx 3401 1 The the DT cord-010092-uftc8inx 3401 2 steering steering NN cord-010092-uftc8inx 3401 3 committee committee NN cord-010092-uftc8inx 3401 4 is be VBZ cord-010092-uftc8inx 3401 5 working work VBG cord-010092-uftc8inx 3401 6 hard hard RB cord-010092-uftc8inx 3401 7 to to TO cord-010092-uftc8inx 3401 8 get get VB cord-010092-uftc8inx 3401 9 cooperation cooperation NN cord-010092-uftc8inx 3401 10 from from IN cord-010092-uftc8inx 3401 11 every every DT cord-010092-uftc8inx 3401 12 service service NN cord-010092-uftc8inx 3401 13 by by IN cord-010092-uftc8inx 3401 14 aiming aim VBG cord-010092-uftc8inx 3401 15 to to TO cord-010092-uftc8inx 3401 16 prevent prevent VB cord-010092-uftc8inx 3401 17 those those DT cord-010092-uftc8inx 3401 18 undesirable undesirable JJ cord-010092-uftc8inx 3401 19 events event NNS cord-010092-uftc8inx 3401 20 before before IN cord-010092-uftc8inx 3401 21 establishment establishment NN cord-010092-uftc8inx 3401 22 of of IN cord-010092-uftc8inx 3401 23 national national JJ cord-010092-uftc8inx 3401 24 level level NN cord-010092-uftc8inx 3401 25 policy policy NN cord-010092-uftc8inx 3401 26 , , , cord-010092-uftc8inx 3401 27 standards standard NNS cord-010092-uftc8inx 3401 28 and and CC cord-010092-uftc8inx 3401 29 guidelines guideline NNS cord-010092-uftc8inx 3401 30 for for IN cord-010092-uftc8inx 3401 31 sustainable sustainable JJ cord-010092-uftc8inx 3401 32 service service NN cord-010092-uftc8inx 3401 33 quality quality NN cord-010092-uftc8inx 3401 34 . . . cord-010092-uftc8inx 3402 1 In in IN cord-010092-uftc8inx 3402 2 conclusion conclusion NN cord-010092-uftc8inx 3402 3 , , , cord-010092-uftc8inx 3402 4 by by IN cord-010092-uftc8inx 3402 5 using use VBG cord-010092-uftc8inx 3402 6 essence essence NN cord-010092-uftc8inx 3402 7 of of IN cord-010092-uftc8inx 3402 8 hemovigilance hemovigilance NN cord-010092-uftc8inx 3402 9 as as IN cord-010092-uftc8inx 3402 10 a a DT cord-010092-uftc8inx 3402 11 tool tool NN cord-010092-uftc8inx 3402 12 , , , cord-010092-uftc8inx 3402 13 quality quality NN cord-010092-uftc8inx 3402 14 of of IN cord-010092-uftc8inx 3402 15 transfusion transfusion NN cord-010092-uftc8inx 3402 16 service service NN cord-010092-uftc8inx 3402 17 can can MD cord-010092-uftc8inx 3402 18 be be VB cord-010092-uftc8inx 3402 19 improved improve VBN cord-010092-uftc8inx 3402 20 step step NN cord-010092-uftc8inx 3402 21 by by IN cord-010092-uftc8inx 3402 22 step step NN cord-010092-uftc8inx 3402 23 to to TO cord-010092-uftc8inx 3402 24 fulfil fulfil VB cord-010092-uftc8inx 3402 25 the the DT cord-010092-uftc8inx 3402 26 gap gap NN cord-010092-uftc8inx 3402 27 in in IN cord-010092-uftc8inx 3402 28 spite spite NN cord-010092-uftc8inx 3402 29 of of IN cord-010092-uftc8inx 3402 30 limited limited JJ cord-010092-uftc8inx 3402 31 resources resource NNS cord-010092-uftc8inx 3402 32 . . . cord-010092-uftc8inx 3403 1 The the DT cord-010092-uftc8inx 3403 2 system system NN cord-010092-uftc8inx 3403 3 started start VBD cord-010092-uftc8inx 3403 4 in in IN cord-010092-uftc8inx 3403 5 local local JJ cord-010092-uftc8inx 3403 6 , , , cord-010092-uftc8inx 3403 7 extends extend VBZ cord-010092-uftc8inx 3403 8 to to IN cord-010092-uftc8inx 3403 9 regional regional JJ cord-010092-uftc8inx 3403 10 level level NN cord-010092-uftc8inx 3403 11 by by IN cord-010092-uftc8inx 3403 12 getting get VBG cord-010092-uftc8inx 3403 13 agreement agreement NN cord-010092-uftc8inx 3403 14 of of IN cord-010092-uftc8inx 3403 15 importance importance NN cord-010092-uftc8inx 3403 16 from from IN cord-010092-uftc8inx 3403 17 hemovigilance hemovigilance NN cord-010092-uftc8inx 3403 18 results result NNS cord-010092-uftc8inx 3403 19 and and CC cord-010092-uftc8inx 3403 20 is be VBZ cord-010092-uftc8inx 3403 21 finally finally RB cord-010092-uftc8inx 3403 22 approaching approach VBG cord-010092-uftc8inx 3403 23 to to IN cord-010092-uftc8inx 3403 24 National national JJ cord-010092-uftc8inx 3403 25 level level NN cord-010092-uftc8inx 3403 26 endorsement endorsement NN cord-010092-uftc8inx 3403 27 . . . cord-010092-uftc8inx 3404 1 Background background NN cord-010092-uftc8inx 3404 2 : : : cord-010092-uftc8inx 3405 1 Erroneous erroneous JJ cord-010092-uftc8inx 3405 2 transfusion transfusion NN cord-010092-uftc8inx 3405 3 of of IN cord-010092-uftc8inx 3405 4 ABO ABO NNP cord-010092-uftc8inx 3405 5 - - HYPH cord-010092-uftc8inx 3405 6 incompatible(ABOi incompatible(ABOi NNP cord-010092-uftc8inx 3405 7 ) ) -RRB- cord-010092-uftc8inx 3406 1 blood blood NN cord-010092-uftc8inx 3406 2 almost almost RB cord-010092-uftc8inx 3406 3 always always RB cord-010092-uftc8inx 3406 4 reflects reflect VBZ cord-010092-uftc8inx 3406 5 a a DT cord-010092-uftc8inx 3406 6 preventable preventable JJ cord-010092-uftc8inx 3406 7 breakdown breakdown NN cord-010092-uftc8inx 3406 8 in in IN cord-010092-uftc8inx 3406 9 transfusion transfusion NN cord-010092-uftc8inx 3406 10 protocols protocol NNS cord-010092-uftc8inx 3406 11 and and CC cord-010092-uftc8inx 3406 12 standard standard JJ cord-010092-uftc8inx 3406 13 operating operating NN cord-010092-uftc8inx 3406 14 procedures procedure NNS cord-010092-uftc8inx 3406 15 and and CC cord-010092-uftc8inx 3406 16 can can MD cord-010092-uftc8inx 3406 17 have have VB cord-010092-uftc8inx 3406 18 disastrous disastrous JJ cord-010092-uftc8inx 3406 19 consequences consequence NNS cord-010092-uftc8inx 3406 20 , , , cord-010092-uftc8inx 3406 21 with with IN cord-010092-uftc8inx 3406 22 significant significant JJ cord-010092-uftc8inx 3406 23 morbidity morbidity NN cord-010092-uftc8inx 3406 24 and and CC cord-010092-uftc8inx 3406 25 mortality mortality NN cord-010092-uftc8inx 3406 26 . . . cord-010092-uftc8inx 3407 1 These these DT cord-010092-uftc8inx 3407 2 incidents incident NNS cord-010092-uftc8inx 3407 3 need need VBP cord-010092-uftc8inx 3407 4 to to TO cord-010092-uftc8inx 3407 5 be be VB cord-010092-uftc8inx 3407 6 investigated investigate VBN cord-010092-uftc8inx 3407 7 in in IN cord-010092-uftc8inx 3407 8 a a DT cord-010092-uftc8inx 3407 9 systematic systematic JJ cord-010092-uftc8inx 3407 10 manner manner NN cord-010092-uftc8inx 3407 11 to to TO cord-010092-uftc8inx 3407 12 identify identify VB cord-010092-uftc8inx 3407 13 system system NN cord-010092-uftc8inx 3407 14 vulnerabilities vulnerability NNS cord-010092-uftc8inx 3407 15 to to TO cord-010092-uftc8inx 3407 16 mitigate mitigate VB cord-010092-uftc8inx 3407 17 risks risk NNS cord-010092-uftc8inx 3407 18 and and CC cord-010092-uftc8inx 3407 19 improve improve VB cord-010092-uftc8inx 3407 20 patient patient JJ cord-010092-uftc8inx 3407 21 safety safety NN cord-010092-uftc8inx 3407 22 . . . cord-010092-uftc8inx 3408 1 Since since IN cord-010092-uftc8inx 3408 2 2016 2016 CD cord-010092-uftc8inx 3408 3 , , , cord-010092-uftc8inx 3408 4 reporters reporter NNS cord-010092-uftc8inx 3408 5 to to IN cord-010092-uftc8inx 3408 6 SHOT SHOT NNP cord-010092-uftc8inx 3408 7 have have VBP cord-010092-uftc8inx 3408 8 been be VBN cord-010092-uftc8inx 3408 9 asked ask VBN cord-010092-uftc8inx 3408 10 to to IN cord-010092-uftc8inx 3408 11 score(0 score(0 CD cord-010092-uftc8inx 3408 12 - - HYPH cord-010092-uftc8inx 3408 13 10 10 CD cord-010092-uftc8inx 3408 14 ) ) -RRB- cord-010092-uftc8inx 3408 15 the the DT cord-010092-uftc8inx 3408 16 extent extent NN cord-010092-uftc8inx 3408 17 to to TO cord-010092-uftc8inx 3408 18 which which WDT cord-010092-uftc8inx 3408 19 the the DT cord-010092-uftc8inx 3408 20 cause cause NN cord-010092-uftc8inx 3408 21 of of IN cord-010092-uftc8inx 3408 22 incidents incident NNS cord-010092-uftc8inx 3408 23 can can MD cord-010092-uftc8inx 3408 24 be be VB cord-010092-uftc8inx 3408 25 attributed attribute VBN cord-010092-uftc8inx 3408 26 to to IN cord-010092-uftc8inx 3408 27 key key JJ cord-010092-uftc8inx 3408 28 factors factor NNS cord-010092-uftc8inx 3408 29 : : : cord-010092-uftc8inx 3408 30 staff staff NN cord-010092-uftc8inx 3408 31 , , , cord-010092-uftc8inx 3408 32 environmental environmental JJ cord-010092-uftc8inx 3408 33 , , , cord-010092-uftc8inx 3408 34 organisational organisational JJ cord-010092-uftc8inx 3408 35 and and CC cord-010092-uftc8inx 3408 36 government government NN cord-010092-uftc8inx 3408 37 / / SYM cord-010092-uftc8inx 3408 38 regulatory regulatory JJ cord-010092-uftc8inx 3408 39 which which WDT cord-010092-uftc8inx 3408 40 helps help VBZ cord-010092-uftc8inx 3408 41 recognise recognise VB cord-010092-uftc8inx 3408 42 the the DT cord-010092-uftc8inx 3408 43 key key JJ cord-010092-uftc8inx 3408 44 factors factor NNS cord-010092-uftc8inx 3408 45 identified identify VBN cord-010092-uftc8inx 3408 46 whilst whilst IN cord-010092-uftc8inx 3408 47 investigating investigate VBG cord-010092-uftc8inx 3408 48 these these DT cord-010092-uftc8inx 3408 49 incidents incident NNS cord-010092-uftc8inx 3408 50 . . . cord-010092-uftc8inx 3409 1 Aims aim VBZ cord-010092-uftc8inx 3409 2 : : : cord-010092-uftc8inx 3410 1 To to TO cord-010092-uftc8inx 3410 2 understand understand VB cord-010092-uftc8inx 3410 3 why why WRB cord-010092-uftc8inx 3410 4 unintentional unintentional JJ cord-010092-uftc8inx 3410 5 transfusion transfusion NN cord-010092-uftc8inx 3410 6 of of IN cord-010092-uftc8inx 3410 7 ABOi ABOi NNP cord-010092-uftc8inx 3410 8 blood blood NN cord-010092-uftc8inx 3410 9 components component NNS cord-010092-uftc8inx 3410 10 continue continue VBP cord-010092-uftc8inx 3410 11 to to TO cord-010092-uftc8inx 3410 12 happen happen VB cord-010092-uftc8inx 3410 13 despite despite IN cord-010092-uftc8inx 3410 14 standard standard JJ cord-010092-uftc8inx 3410 15 procedures procedure NNS cord-010092-uftc8inx 3410 16 and and CC cord-010092-uftc8inx 3410 17 national national JJ cord-010092-uftc8inx 3410 18 guidance guidance NN cord-010092-uftc8inx 3410 19 available available JJ cord-010092-uftc8inx 3410 20 . . . cord-010092-uftc8inx 3411 1 Methods method NNS cord-010092-uftc8inx 3411 2 : : : cord-010092-uftc8inx 3412 1 Retrospective retrospective JJ cord-010092-uftc8inx 3412 2 analysis analysis NN cord-010092-uftc8inx 3412 3 of of IN cord-010092-uftc8inx 3412 4 unintentional unintentional JJ cord-010092-uftc8inx 3412 5 transfusion transfusion NN cord-010092-uftc8inx 3412 6 of of IN cord-010092-uftc8inx 3412 7 ABOi ABOi NNP cord-010092-uftc8inx 3412 8 blood blood NN cord-010092-uftc8inx 3412 9 components component NNS cord-010092-uftc8inx 3412 10 reported report VBN cord-010092-uftc8inx 3412 11 to to IN cord-010092-uftc8inx 3412 12 SHOT shot NN cord-010092-uftc8inx 3412 13 between between IN cord-010092-uftc8inx 3412 14 2010 2010 CD cord-010092-uftc8inx 3412 15 - - SYM cord-010092-uftc8inx 3412 16 2017(inclusive 2017(inclusive CD cord-010092-uftc8inx 3412 17 ) ) -RRB- cord-010092-uftc8inx 3412 18 was be VBD cord-010092-uftc8inx 3412 19 done do VBN cord-010092-uftc8inx 3412 20 to to TO cord-010092-uftc8inx 3412 21 identify identify VB cord-010092-uftc8inx 3412 22 common common JJ cord-010092-uftc8inx 3412 23 themes theme NNS cord-010092-uftc8inx 3412 24 and and CC cord-010092-uftc8inx 3412 25 recognise recognise VBP cord-010092-uftc8inx 3412 26 areas area NNS cord-010092-uftc8inx 3412 27 of of IN cord-010092-uftc8inx 3412 28 improvement improvement NN cord-010092-uftc8inx 3412 29 . . . cord-010092-uftc8inx 3413 1 Information information NN cord-010092-uftc8inx 3413 2 provided provide VBN cord-010092-uftc8inx 3413 3 using use VBG cord-010092-uftc8inx 3413 4 the the DT cord-010092-uftc8inx 3413 5 SHOT SHOT NNP cord-010092-uftc8inx 3413 6 human human JJ cord-010092-uftc8inx 3413 7 factors factor NNS cord-010092-uftc8inx 3413 8 investigation investigation NN cord-010092-uftc8inx 3413 9 tool tool NN cord-010092-uftc8inx 3413 10 ( ( -LRB- cord-010092-uftc8inx 3413 11 HFIT HFIT NNP cord-010092-uftc8inx 3413 12 ) ) -RRB- cord-010092-uftc8inx 3413 13 between between IN cord-010092-uftc8inx 3413 14 2016 2016 CD cord-010092-uftc8inx 3413 15 - - SYM cord-010092-uftc8inx 3413 16 2017 2017 CD cord-010092-uftc8inx 3413 17 was be VBD cord-010092-uftc8inx 3413 18 reviewed review VBN cord-010092-uftc8inx 3413 19 to to TO cord-010092-uftc8inx 3413 20 understand understand VB cord-010092-uftc8inx 3413 21 more more JJR cord-010092-uftc8inx 3413 22 about about IN cord-010092-uftc8inx 3413 23 why why WRB cord-010092-uftc8inx 3413 24 the the DT cord-010092-uftc8inx 3413 25 errors error NNS cord-010092-uftc8inx 3413 26 occurred occur VBD cord-010092-uftc8inx 3413 27 . . . cord-010092-uftc8inx 3414 1 Results result NNS cord-010092-uftc8inx 3414 2 : : : cord-010092-uftc8inx 3415 1 Sixty sixty CD cord-010092-uftc8inx 3415 2 - - HYPH cord-010092-uftc8inx 3415 3 seven seven CD cord-010092-uftc8inx 3415 4 unintentional unintentional JJ cord-010092-uftc8inx 3415 5 ABOi ABOi NNS cord-010092-uftc8inx 3415 6 transfusions transfusion NNS cord-010092-uftc8inx 3415 7 were be VBD cord-010092-uftc8inx 3415 8 reported report VBN cord-010092-uftc8inx 3415 9 between between IN cord-010092-uftc8inx 3415 10 2010 2010 CD cord-010092-uftc8inx 3415 11 - - SYM cord-010092-uftc8inx 3415 12 2017 2017 CD cord-010092-uftc8inx 3415 13 ; ; : cord-010092-uftc8inx 3415 14 majority majority NN cord-010092-uftc8inx 3415 15 ( ( -LRB- cord-010092-uftc8inx 3415 16 56/67 56/67 CD cord-010092-uftc8inx 3415 17 , , , cord-010092-uftc8inx 3415 18 83.6 83.6 CD cord-010092-uftc8inx 3415 19 % % NN cord-010092-uftc8inx 3415 20 ) ) -RRB- cord-010092-uftc8inx 3415 21 were be VBD cord-010092-uftc8inx 3415 22 red red JJ cord-010092-uftc8inx 3415 23 cell cell NN cord-010092-uftc8inx 3415 24 transfusions transfusion NNS cord-010092-uftc8inx 3415 25 but but CC cord-010092-uftc8inx 3415 26 ABOi aboi NN cord-010092-uftc8inx 3415 27 plasma plasma NN cord-010092-uftc8inx 3415 28 ( ( -LRB- cord-010092-uftc8inx 3415 29 9/67 9/67 CD cord-010092-uftc8inx 3415 30 ) ) -RRB- cord-010092-uftc8inx 3415 31 and and CC cord-010092-uftc8inx 3415 32 platelet platelet NN cord-010092-uftc8inx 3415 33 transfusions transfusion NNS cord-010092-uftc8inx 3415 34 ( ( -LRB- cord-010092-uftc8inx 3415 35 2/67 2/67 CD cord-010092-uftc8inx 3415 36 ) ) -RRB- cord-010092-uftc8inx 3415 37 were be VBD cord-010092-uftc8inx 3415 38 also also RB cord-010092-uftc8inx 3415 39 seen see VBN cord-010092-uftc8inx 3415 40 . . . cord-010092-uftc8inx 3416 1 Most Most JJS cord-010092-uftc8inx 3416 2 errors error NNS cord-010092-uftc8inx 3416 3 occurred occur VBD cord-010092-uftc8inx 3416 4 in in IN cord-010092-uftc8inx 3416 5 the the DT cord-010092-uftc8inx 3416 6 clinical clinical JJ cord-010092-uftc8inx 3416 7 area area NN cord-010092-uftc8inx 3416 8 ( ( -LRB- cord-010092-uftc8inx 3416 9 45/67 45/67 CD cord-010092-uftc8inx 3416 10 , , , cord-010092-uftc8inx 3416 11 67 67 CD cord-010092-uftc8inx 3416 12 % % NN cord-010092-uftc8inx 3416 13 ) ) -RRB- cord-010092-uftc8inx 3416 14 , , , cord-010092-uftc8inx 3416 15 and and CC cord-010092-uftc8inx 3416 16 could could MD cord-010092-uftc8inx 3416 17 have have VB cord-010092-uftc8inx 3416 18 been be VBN cord-010092-uftc8inx 3416 19 detected detect VBN cord-010092-uftc8inx 3416 20 at at IN cord-010092-uftc8inx 3416 21 point point NN cord-010092-uftc8inx 3416 22 of of IN cord-010092-uftc8inx 3416 23 administration administration NN cord-010092-uftc8inx 3416 24 . . . cord-010092-uftc8inx 3417 1 In in IN cord-010092-uftc8inx 3417 2 21(31 21(31 CD cord-010092-uftc8inx 3417 3 % % NN cord-010092-uftc8inx 3417 4 ) ) -RRB- cord-010092-uftc8inx 3417 5 cases case NNS cord-010092-uftc8inx 3417 6 , , , cord-010092-uftc8inx 3417 7 the the DT cord-010092-uftc8inx 3417 8 error error NN cord-010092-uftc8inx 3417 9 could could MD cord-010092-uftc8inx 3417 10 not not RB cord-010092-uftc8inx 3417 11 have have VB cord-010092-uftc8inx 3417 12 be be VB cord-010092-uftc8inx 3417 13 detected detect VBN cord-010092-uftc8inx 3417 14 at at IN cord-010092-uftc8inx 3417 15 the the DT cord-010092-uftc8inx 3417 16 point point NN cord-010092-uftc8inx 3417 17 of of IN cord-010092-uftc8inx 3417 18 administration administration NN cord-010092-uftc8inx 3417 19 with with IN cord-010092-uftc8inx 3417 20 a a DT cord-010092-uftc8inx 3417 21 primary primary JJ cord-010092-uftc8inx 3417 22 laboratory laboratory NN cord-010092-uftc8inx 3417 23 error error NN cord-010092-uftc8inx 3417 24 in in IN cord-010092-uftc8inx 3417 25 10/21(48 10/21(48 CD cord-010092-uftc8inx 3417 26 % % NN cord-010092-uftc8inx 3417 27 ) ) -RRB- cord-010092-uftc8inx 3417 28 incidents incident NNS cord-010092-uftc8inx 3417 29 . . . cord-010092-uftc8inx 3418 1 Reviewing review VBG cord-010092-uftc8inx 3418 2 data datum NNS cord-010092-uftc8inx 3418 3 from from IN cord-010092-uftc8inx 3418 4 HFIT HFIT NNP cord-010092-uftc8inx 3418 5 for for IN cord-010092-uftc8inx 3418 6 cases case NNS cord-010092-uftc8inx 3418 7 in in IN cord-010092-uftc8inx 3418 8 2016 2016 CD cord-010092-uftc8inx 3418 9 - - SYM cord-010092-uftc8inx 3418 10 2017 2017 CD cord-010092-uftc8inx 3418 11 ( ( -LRB- cord-010092-uftc8inx 3418 12 13 13 CD cord-010092-uftc8inx 3418 13 ABOi ABOi NNS cord-010092-uftc8inx 3418 14 cases case NNS cord-010092-uftc8inx 3418 15 ) ) -RRB- cord-010092-uftc8inx 3418 16 , , , cord-010092-uftc8inx 3418 17 the the DT cord-010092-uftc8inx 3418 18 total total JJ cord-010092-uftc8inx 3418 19 score score NN cord-010092-uftc8inx 3418 20 for for IN cord-010092-uftc8inx 3418 21 staff staff NN cord-010092-uftc8inx 3418 22 culpability culpability NN cord-010092-uftc8inx 3418 23 was be VBD cord-010092-uftc8inx 3418 24 100 100 CD cord-010092-uftc8inx 3418 25 , , , cord-010092-uftc8inx 3418 26 compared compare VBN cord-010092-uftc8inx 3418 27 to to IN cord-010092-uftc8inx 3418 28 a a DT cord-010092-uftc8inx 3418 29 total total JJ cord-010092-uftc8inx 3418 30 score score NN cord-010092-uftc8inx 3418 31 of of IN cord-010092-uftc8inx 3418 32 99 99 CD cord-010092-uftc8inx 3418 33 for for IN cord-010092-uftc8inx 3418 34 all all PDT cord-010092-uftc8inx 3418 35 the the DT cord-010092-uftc8inx 3418 36 other other JJ cord-010092-uftc8inx 3418 37 three three CD cord-010092-uftc8inx 3418 38 organisational organisational JJ cord-010092-uftc8inx 3418 39 and and CC cord-010092-uftc8inx 3418 40 system system NN cord-010092-uftc8inx 3418 41 factors factor NNS cord-010092-uftc8inx 3418 42 . . . cord-010092-uftc8inx 3419 1 This this DT cord-010092-uftc8inx 3419 2 disparity disparity NN cord-010092-uftc8inx 3419 3 is be VBZ cord-010092-uftc8inx 3419 4 most most RBS cord-010092-uftc8inx 3419 5 obvious obvious JJ cord-010092-uftc8inx 3419 6 for for IN cord-010092-uftc8inx 3419 7 the the DT cord-010092-uftc8inx 3419 8 4 4 CD cord-010092-uftc8inx 3419 9 ABOi ABOi NNS cord-010092-uftc8inx 3419 10 red red JJ cord-010092-uftc8inx 3419 11 cell cell NN cord-010092-uftc8inx 3419 12 cases case NNS cord-010092-uftc8inx 3419 13 , , , cord-010092-uftc8inx 3419 14 all all DT cord-010092-uftc8inx 3419 15 of of IN cord-010092-uftc8inx 3419 16 which which WDT cord-010092-uftc8inx 3419 17 scored score VBD cord-010092-uftc8inx 3419 18 the the DT cord-010092-uftc8inx 3419 19 maximum maximum JJ cord-010092-uftc8inx 3419 20 10 10 CD cord-010092-uftc8inx 3419 21 for for IN cord-010092-uftc8inx 3419 22 staff staff NN cord-010092-uftc8inx 3419 23 culpability culpability NN cord-010092-uftc8inx 3419 24 , , , cord-010092-uftc8inx 3419 25 i.e. i.e. FW cord-010092-uftc8inx 3419 26 40/40 40/40 CD cord-010092-uftc8inx 3419 27 compared compare VBN cord-010092-uftc8inx 3419 28 to to IN cord-010092-uftc8inx 3419 29 8/120 8/120 CD cord-010092-uftc8inx 3419 30 as as IN cord-010092-uftc8inx 3419 31 the the DT cord-010092-uftc8inx 3419 32 combined combined JJ cord-010092-uftc8inx 3419 33 total total JJ cord-010092-uftc8inx 3419 34 score score NN cord-010092-uftc8inx 3419 35 given give VBN cord-010092-uftc8inx 3419 36 to to IN cord-010092-uftc8inx 3419 37 the the DT cord-010092-uftc8inx 3419 38 other other JJ cord-010092-uftc8inx 3419 39 factors factor NNS cord-010092-uftc8inx 3419 40 . . . cord-010092-uftc8inx 3420 1 In in IN cord-010092-uftc8inx 3420 2 the the DT cord-010092-uftc8inx 3420 3 preceding precede VBG cord-010092-uftc8inx 3420 4 years year NNS cord-010092-uftc8inx 3420 5 ( ( -LRB- cord-010092-uftc8inx 3420 6 2010 2010 CD cord-010092-uftc8inx 3420 7 to to IN cord-010092-uftc8inx 3420 8 2015 2015 CD cord-010092-uftc8inx 3420 9 ) ) -RRB- cord-010092-uftc8inx 3420 10 , , , cord-010092-uftc8inx 3420 11 there there EX cord-010092-uftc8inx 3420 12 were be VBD cord-010092-uftc8inx 3420 13 no no DT cord-010092-uftc8inx 3420 14 HF HF NNP cord-010092-uftc8inx 3420 15 scores score NNS cord-010092-uftc8inx 3420 16 available available JJ cord-010092-uftc8inx 3420 17 ; ; : cord-010092-uftc8inx 3420 18 however however RB cord-010092-uftc8inx 3420 19 , , , cord-010092-uftc8inx 3420 20 the the DT cord-010092-uftc8inx 3420 21 emphasis emphasis NN cord-010092-uftc8inx 3420 22 on on IN cord-010092-uftc8inx 3420 23 staff staff NN cord-010092-uftc8inx 3420 24 - - HYPH cord-010092-uftc8inx 3420 25 related relate VBN cord-010092-uftc8inx 3420 26 culpability culpability NN cord-010092-uftc8inx 3420 27 is be VBZ cord-010092-uftc8inx 3420 28 demonstrated demonstrate VBN cord-010092-uftc8inx 3420 29 by by IN cord-010092-uftc8inx 3420 30 37 37 CD cord-010092-uftc8inx 3420 31 cases case NNS cord-010092-uftc8inx 3420 32 that that WDT cord-010092-uftc8inx 3420 33 included include VBD cord-010092-uftc8inx 3420 34 an an DT cord-010092-uftc8inx 3420 35 outcome outcome NN cord-010092-uftc8inx 3420 36 of of IN cord-010092-uftc8inx 3420 37 the the DT cord-010092-uftc8inx 3420 38 local local JJ cord-010092-uftc8inx 3420 39 case case NN cord-010092-uftc8inx 3420 40 review review NN cord-010092-uftc8inx 3420 41 and and CC cord-010092-uftc8inx 3420 42 14 14 CD cord-010092-uftc8inx 3420 43 ( ( -LRB- cord-010092-uftc8inx 3420 44 37.8 37.8 CD cord-010092-uftc8inx 3420 45 % % NN cord-010092-uftc8inx 3420 46 ) ) -RRB- cord-010092-uftc8inx 3420 47 mentioned mention VBD cord-010092-uftc8inx 3420 48 staff staff NN cord-010092-uftc8inx 3420 49 - - HYPH cord-010092-uftc8inx 3420 50 related relate VBN cord-010092-uftc8inx 3420 51 retraining retraining NN cord-010092-uftc8inx 3420 52 or or CC cord-010092-uftc8inx 3420 53 disciplinary disciplinary JJ cord-010092-uftc8inx 3420 54 procedures procedure NNS cord-010092-uftc8inx 3420 55 . . . cord-010092-uftc8inx 3421 1 The the DT cord-010092-uftc8inx 3421 2 risk risk NN cord-010092-uftc8inx 3421 3 of of IN cord-010092-uftc8inx 3421 4 haemolysis haemolysis NN cord-010092-uftc8inx 3421 5 and and CC cord-010092-uftc8inx 3421 6 serious serious JJ cord-010092-uftc8inx 3421 7 harm harm NN cord-010092-uftc8inx 3421 8 is be VBZ cord-010092-uftc8inx 3421 9 more more RBR cord-010092-uftc8inx 3421 10 likely likely JJ cord-010092-uftc8inx 3421 11 with with IN cord-010092-uftc8inx 3421 12 ABOi ABOi NNS cord-010092-uftc8inx 3421 13 red red JJ cord-010092-uftc8inx 3421 14 cells cell NNS cord-010092-uftc8inx 3421 15 than than IN cord-010092-uftc8inx 3421 16 with with IN cord-010092-uftc8inx 3421 17 other other JJ cord-010092-uftc8inx 3421 18 components component NNS cord-010092-uftc8inx 3421 19 with with IN cord-010092-uftc8inx 3421 20 2/56(4 2/56(4 CD cord-010092-uftc8inx 3421 21 % % NN cord-010092-uftc8inx 3421 22 ) ) -RRB- cord-010092-uftc8inx 3421 23 that that WDT cord-010092-uftc8inx 3421 24 resulted result VBD cord-010092-uftc8inx 3421 25 in in IN cord-010092-uftc8inx 3421 26 death death NN cord-010092-uftc8inx 3421 27 , , , cord-010092-uftc8inx 3421 28 14/ 14/ CD cord-010092-uftc8inx 3421 29 56(25 56(25 CD cord-010092-uftc8inx 3421 30 % % NN cord-010092-uftc8inx 3421 31 ) ) -RRB- cord-010092-uftc8inx 3421 32 major major JJ cord-010092-uftc8inx 3421 33 morbidity morbidity NN cord-010092-uftc8inx 3421 34 and and CC cord-010092-uftc8inx 3421 35 40/56(71 40/56(71 CD cord-010092-uftc8inx 3421 36 % % NN cord-010092-uftc8inx 3421 37 ) ) -RRB- cord-010092-uftc8inx 3422 1 no no DT cord-010092-uftc8inx 3422 2 or or CC cord-010092-uftc8inx 3422 3 minor minor JJ cord-010092-uftc8inx 3422 4 adverse adverse JJ cord-010092-uftc8inx 3422 5 reaction reaction NN cord-010092-uftc8inx 3422 6 . . . cord-010092-uftc8inx 3423 1 Of of IN cord-010092-uftc8inx 3423 2 these these DT cord-010092-uftc8inx 3423 3 cases case NNS cord-010092-uftc8inx 3423 4 , , , cord-010092-uftc8inx 3423 5 one one CD cord-010092-uftc8inx 3423 6 resulted result VBD cord-010092-uftc8inx 3423 7 in in IN cord-010092-uftc8inx 3423 8 conviction conviction NN cord-010092-uftc8inx 3423 9 for for IN cord-010092-uftc8inx 3423 10 manslaughter manslaughter NN cord-010092-uftc8inx 3423 11 and and CC cord-010092-uftc8inx 3423 12 at at RB cord-010092-uftc8inx 3423 13 least least RBS cord-010092-uftc8inx 3423 14 two two CD cord-010092-uftc8inx 3423 15 staff staff NN cord-010092-uftc8inx 3423 16 dismissals dismissal NNS cord-010092-uftc8inx 3423 17 . . . cord-010092-uftc8inx 3424 1 Summary Summary NNP cord-010092-uftc8inx 3424 2 / / SYM cord-010092-uftc8inx 3424 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 3424 4 : : : cord-010092-uftc8inx 3425 1 Transfusion transfusion NN cord-010092-uftc8inx 3425 2 never never RB cord-010092-uftc8inx 3425 3 events event NNS cord-010092-uftc8inx 3425 4 continue continue VBP cord-010092-uftc8inx 3425 5 to to TO cord-010092-uftc8inx 3425 6 occur occur VB cord-010092-uftc8inx 3425 7 , , , cord-010092-uftc8inx 3425 8 and and CC cord-010092-uftc8inx 3425 9 it -PRON- PRP cord-010092-uftc8inx 3425 10 is be VBZ cord-010092-uftc8inx 3425 11 evident evident JJ cord-010092-uftc8inx 3425 12 that that IN cord-010092-uftc8inx 3425 13 investigations investigation NNS cord-010092-uftc8inx 3425 14 into into IN cord-010092-uftc8inx 3425 15 such such JJ cord-010092-uftc8inx 3425 16 incidents incident NNS cord-010092-uftc8inx 3425 17 focus focus VBP cord-010092-uftc8inx 3425 18 mainly mainly RB cord-010092-uftc8inx 3425 19 on on IN cord-010092-uftc8inx 3425 20 staff staff NN cord-010092-uftc8inx 3425 21 failings failing NNS cord-010092-uftc8inx 3425 22 and and CC cord-010092-uftc8inx 3425 23 do do VBP cord-010092-uftc8inx 3425 24 not not RB cord-010092-uftc8inx 3425 25 consistently consistently RB cord-010092-uftc8inx 3425 26 identify identify VB cord-010092-uftc8inx 3425 27 system system NN cord-010092-uftc8inx 3425 28 wide wide JJ cord-010092-uftc8inx 3425 29 changes change NNS cord-010092-uftc8inx 3425 30 that that WDT cord-010092-uftc8inx 3425 31 need need VBP cord-010092-uftc8inx 3425 32 to to TO cord-010092-uftc8inx 3425 33 be be VB cord-010092-uftc8inx 3425 34 incorporated incorporate VBN cord-010092-uftc8inx 3425 35 to to TO cord-010092-uftc8inx 3425 36 address address VB cord-010092-uftc8inx 3425 37 prevalent prevalent JJ cord-010092-uftc8inx 3425 38 issues issue NNS cord-010092-uftc8inx 3425 39 . . . cord-010092-uftc8inx 3426 1 National national JJ cord-010092-uftc8inx 3426 2 recommendations recommendation NNS cord-010092-uftc8inx 3426 3 and and CC cord-010092-uftc8inx 3426 4 a a DT cord-010092-uftc8inx 3426 5 safety safety NN cord-010092-uftc8inx 3426 6 alert alert NN cord-010092-uftc8inx 3426 7 to to TO cord-010092-uftc8inx 3426 8 ' ' `` cord-010092-uftc8inx 3426 9 use use VB cord-010092-uftc8inx 3426 10 a a DT cord-010092-uftc8inx 3426 11 bedside bedside NN cord-010092-uftc8inx 3426 12 checklist checklist NN cord-010092-uftc8inx 3426 13 ' ' '' cord-010092-uftc8inx 3426 14 immediately immediately RB cord-010092-uftc8inx 3426 15 prior prior RB cord-010092-uftc8inx 3426 16 to to IN cord-010092-uftc8inx 3426 17 administration administration NN cord-010092-uftc8inx 3426 18 were be VBD cord-010092-uftc8inx 3426 19 issued issue VBN cord-010092-uftc8inx 3426 20 between between IN cord-010092-uftc8inx 3426 21 2015 2015 CD cord-010092-uftc8inx 3426 22 - - SYM cord-010092-uftc8inx 3426 23 2018 2018 CD cord-010092-uftc8inx 3426 24 to to TO cord-010092-uftc8inx 3426 25 support support VB cord-010092-uftc8inx 3426 26 prevention prevention NN cord-010092-uftc8inx 3426 27 of of IN cord-010092-uftc8inx 3426 28 such such JJ cord-010092-uftc8inx 3426 29 errors error NNS cord-010092-uftc8inx 3426 30 but but CC cord-010092-uftc8inx 3426 31 never never RB cord-010092-uftc8inx 3426 32 events event NNS cord-010092-uftc8inx 3426 33 continue continue VBP cord-010092-uftc8inx 3426 34 to to TO cord-010092-uftc8inx 3426 35 persist persist VB cord-010092-uftc8inx 3426 36 . . . cord-010092-uftc8inx 3427 1 Current current JJ cord-010092-uftc8inx 3427 2 approach approach NN cord-010092-uftc8inx 3427 3 is be VBZ cord-010092-uftc8inx 3427 4 ineffective ineffective JJ cord-010092-uftc8inx 3427 5 because because IN cord-010092-uftc8inx 3427 6 it -PRON- PRP cord-010092-uftc8inx 3427 7 often often RB cord-010092-uftc8inx 3427 8 leads lead VBZ cord-010092-uftc8inx 3427 9 to to IN cord-010092-uftc8inx 3427 10 apportioning apportion VBG cord-010092-uftc8inx 3427 11 blame blame NN cord-010092-uftc8inx 3427 12 , , , cord-010092-uftc8inx 3427 13 rather rather RB cord-010092-uftc8inx 3427 14 than than IN cord-010092-uftc8inx 3427 15 understanding understand VBG cord-010092-uftc8inx 3427 16 the the DT cord-010092-uftc8inx 3427 17 often often RB cord-010092-uftc8inx 3427 18 - - HYPH cord-010092-uftc8inx 3427 19 complicated complicate VBN cord-010092-uftc8inx 3427 20 and and CC cord-010092-uftc8inx 3427 21 multidimensional multidimensional JJ cord-010092-uftc8inx 3427 22 factors factor NNS cord-010092-uftc8inx 3427 23 contributing contribute VBG cord-010092-uftc8inx 3427 24 to to IN cord-010092-uftc8inx 3427 25 the the DT cord-010092-uftc8inx 3427 26 error error NN cord-010092-uftc8inx 3427 27 . . . cord-010092-uftc8inx 3428 1 This this DT cord-010092-uftc8inx 3428 2 must must MD cord-010092-uftc8inx 3428 3 be be VB cord-010092-uftc8inx 3428 4 replaced replace VBN cord-010092-uftc8inx 3428 5 by by IN cord-010092-uftc8inx 3428 6 a a DT cord-010092-uftc8inx 3428 7 holistic holistic JJ cord-010092-uftc8inx 3428 8 approach approach NN cord-010092-uftc8inx 3428 9 which which WDT cord-010092-uftc8inx 3428 10 addresses address VBZ cord-010092-uftc8inx 3428 11 local local JJ cord-010092-uftc8inx 3428 12 work work NN cord-010092-uftc8inx 3428 13 pressures pressure NNS cord-010092-uftc8inx 3428 14 and and CC cord-010092-uftc8inx 3428 15 embraces embrace VBZ cord-010092-uftc8inx 3428 16 advances advance NNS cord-010092-uftc8inx 3428 17 in in IN cord-010092-uftc8inx 3428 18 automated automate VBN cord-010092-uftc8inx 3428 19 technology technology NN cord-010092-uftc8inx 3428 20 like like IN cord-010092-uftc8inx 3428 21 electronic electronic JJ cord-010092-uftc8inx 3428 22 prescribing prescribing NN cord-010092-uftc8inx 3428 23 and and CC cord-010092-uftc8inx 3428 24 barcode barcode NN cord-010092-uftc8inx 3428 25 scanning scanning NN cord-010092-uftc8inx 3428 26 . . . cord-010092-uftc8inx 3429 1 Of of IN cord-010092-uftc8inx 3429 2 the the DT cord-010092-uftc8inx 3429 3 confirmed confirm VBN cord-010092-uftc8inx 3429 4 TRARs TRARs NNP cord-010092-uftc8inx 3429 5 , , , cord-010092-uftc8inx 3429 6 n n NN cord-010092-uftc8inx 3429 7 = = SYM cord-010092-uftc8inx 3429 8 27 27 CD cord-010092-uftc8inx 3429 9 were be VBD cord-010092-uftc8inx 3429 10 possibly possibly RB cord-010092-uftc8inx 3429 11 related relate VBN cord-010092-uftc8inx 3429 12 to to IN cord-010092-uftc8inx 3429 13 treatment treatment NN cord-010092-uftc8inx 3429 14 , , , cord-010092-uftc8inx 3429 15 n n NN cord-010092-uftc8inx 3429 16 = = NN cord-010092-uftc8inx 3430 1 2 2 LS cord-010092-uftc8inx 3430 2 TRARs trar NNS cord-010092-uftc8inx 3430 3 were be VBD cord-010092-uftc8inx 3430 4 probable probable JJ cord-010092-uftc8inx 3430 5 , , , cord-010092-uftc8inx 3430 6 and and CC cord-010092-uftc8inx 3430 7 n n NN cord-010092-uftc8inx 3430 8 = = SYM cord-010092-uftc8inx 3430 9 2 2 CD cord-010092-uftc8inx 3430 10 were be VBD cord-010092-uftc8inx 3430 11 definitely definitely RB cord-010092-uftc8inx 3430 12 related relate VBN cord-010092-uftc8inx 3430 13 to to IN cord-010092-uftc8inx 3430 14 treatment treatment NN cord-010092-uftc8inx 3430 15 ; ; : cord-010092-uftc8inx 3430 16 n n NN cord-010092-uftc8inx 3430 17 = = NN cord-010092-uftc8inx 3431 1 37 37 CD cord-010092-uftc8inx 3431 2 TRARs trar NNS cord-010092-uftc8inx 3431 3 were be VBD cord-010092-uftc8inx 3431 4 Grade Grade NNP cord-010092-uftc8inx 3431 5 1 1 CD cord-010092-uftc8inx 3431 6 , , , cord-010092-uftc8inx 3431 7 n n NN cord-010092-uftc8inx 3431 8 = = SYM cord-010092-uftc8inx 3431 9 4 4 CD cord-010092-uftc8inx 3431 10 were be VBD cord-010092-uftc8inx 3431 11 Grade Grade NNP cord-010092-uftc8inx 3431 12 2 2 CD cord-010092-uftc8inx 3431 13 , , , cord-010092-uftc8inx 3431 14 and and CC cord-010092-uftc8inx 3431 15 none none NN cord-010092-uftc8inx 3431 16 were be VBD cord-010092-uftc8inx 3431 17 Grade Grade NNP cord-010092-uftc8inx 3431 18 4 4 CD cord-010092-uftc8inx 3431 19 . . . cord-010092-uftc8inx 3432 1 In in IN cord-010092-uftc8inx 3432 2 recipients recipient NNS cord-010092-uftc8inx 3432 3 of of IN cord-010092-uftc8inx 3432 4 conventional conventional JJ cord-010092-uftc8inx 3432 5 WB WB NNP cord-010092-uftc8inx 3432 6 , , , cord-010092-uftc8inx 3432 7 there there EX cord-010092-uftc8inx 3432 8 were be VBD cord-010092-uftc8inx 3433 1 n n NN cord-010092-uftc8inx 3433 2 = = SYM cord-010092-uftc8inx 3433 3 13 13 CD cord-010092-uftc8inx 3433 4 ( ( -LRB- cord-010092-uftc8inx 3433 5 1.12 1.12 CD cord-010092-uftc8inx 3433 6 % % NN cord-010092-uftc8inx 3433 7 ) ) -RRB- cord-010092-uftc8inx 3434 1 ARs ARs NNP cord-010092-uftc8inx 3434 2 , , , cord-010092-uftc8inx 3434 3 n n NN cord-010092-uftc8inx 3434 4 = = SYM cord-010092-uftc8inx 3434 5 32 32 CD cord-010092-uftc8inx 3434 6 ( ( -LRB- cord-010092-uftc8inx 3434 7 2.75 2.75 CD cord-010092-uftc8inx 3434 8 % % NN cord-010092-uftc8inx 3434 9 ) ) -RRB- cord-010092-uftc8inx 3434 10 FNHTRs fnhtr NNS cord-010092-uftc8inx 3434 11 , , , cord-010092-uftc8inx 3434 12 n n NN cord-010092-uftc8inx 3434 13 = = SYM cord-010092-uftc8inx 3434 14 1 1 CD cord-010092-uftc8inx 3434 15 ( ( -LRB- cord-010092-uftc8inx 3434 16 0.09 0.09 CD cord-010092-uftc8inx 3434 17 % % NN cord-010092-uftc8inx 3434 18 ) ) -RRB- cord-010092-uftc8inx 3435 1 TACO TACO NNP cord-010092-uftc8inx 3435 2 , , , cord-010092-uftc8inx 3435 3 n n NN cord-010092-uftc8inx 3435 4 = = SYM cord-010092-uftc8inx 3435 5 0 0 NFP cord-010092-uftc8inx 3435 6 TRALI TRALI NNP cord-010092-uftc8inx 3435 7 , , , cord-010092-uftc8inx 3435 8 and and CC cord-010092-uftc8inx 3435 9 n n NN cord-010092-uftc8inx 3435 10 = = SYM cord-010092-uftc8inx 3435 11 16 16 CD cord-010092-uftc8inx 3435 12 ( ( -LRB- cord-010092-uftc8inx 3435 13 1.38 1.38 CD cord-010092-uftc8inx 3435 14 % % NN cord-010092-uftc8inx 3435 15 ) ) -RRB- cord-010092-uftc8inx 3435 16 unclassified unclassified JJ cord-010092-uftc8inx 3435 17 transfusion transfusion NN cord-010092-uftc8inx 3435 18 reactions reaction NNS cord-010092-uftc8inx 3435 19 . . . cord-010092-uftc8inx 3436 1 Of of IN cord-010092-uftc8inx 3436 2 the the DT cord-010092-uftc8inx 3436 3 confirmed confirm VBN cord-010092-uftc8inx 3436 4 TRARs TRARs NNP cord-010092-uftc8inx 3436 5 , , , cord-010092-uftc8inx 3436 6 n n NN cord-010092-uftc8inx 3436 7 = = SYM cord-010092-uftc8inx 3436 8 55 55 CD cord-010092-uftc8inx 3436 9 were be VBD cord-010092-uftc8inx 3436 10 possibly possibly RB cord-010092-uftc8inx 3436 11 related relate VBN cord-010092-uftc8inx 3436 12 to to IN cord-010092-uftc8inx 3436 13 treatment treatment NN cord-010092-uftc8inx 3436 14 , , , cord-010092-uftc8inx 3437 1 n n NN cord-010092-uftc8inx 3437 2 = = SYM cord-010092-uftc8inx 3437 3 1 1 CD cord-010092-uftc8inx 3437 4 TRAR TRAR NNP cord-010092-uftc8inx 3437 5 was be VBD cord-010092-uftc8inx 3437 6 probable probable JJ cord-010092-uftc8inx 3437 7 , , , cord-010092-uftc8inx 3437 8 and and CC cord-010092-uftc8inx 3437 9 n n NN cord-010092-uftc8inx 3437 10 = = SYM cord-010092-uftc8inx 3437 11 8 8 CD cord-010092-uftc8inx 3437 12 were be VBD cord-010092-uftc8inx 3437 13 definitely definitely RB cord-010092-uftc8inx 3437 14 related relate VBN cord-010092-uftc8inx 3437 15 to to IN cord-010092-uftc8inx 3437 16 treatment treatment NN cord-010092-uftc8inx 3437 17 ; ; : cord-010092-uftc8inx 3437 18 n n NN cord-010092-uftc8inx 3438 1 = = SYM cord-010092-uftc8inx 3438 2 54 54 CD cord-010092-uftc8inx 3438 3 TRARs trar NNS cord-010092-uftc8inx 3438 4 were be VBD cord-010092-uftc8inx 3438 5 Grade Grade NNP cord-010092-uftc8inx 3438 6 1 1 CD cord-010092-uftc8inx 3438 7 , , , cord-010092-uftc8inx 3438 8 n n NN cord-010092-uftc8inx 3438 9 = = SYM cord-010092-uftc8inx 3438 10 1 1 CD cord-010092-uftc8inx 3438 11 was be VBD cord-010092-uftc8inx 3438 12 Grade Grade NNP cord-010092-uftc8inx 3438 13 2 2 CD cord-010092-uftc8inx 3438 14 and and CC cord-010092-uftc8inx 3438 15 n n NN cord-010092-uftc8inx 3438 16 = = SYM cord-010092-uftc8inx 3438 17 1 1 CD cord-010092-uftc8inx 3439 1 was be VBD cord-010092-uftc8inx 3439 2 Grade Grade NNP cord-010092-uftc8inx 3439 3 4 4 CD cord-010092-uftc8inx 3439 4 . . . cord-010092-uftc8inx 3440 1 There there EX cord-010092-uftc8inx 3440 2 were be VBD cord-010092-uftc8inx 3440 3 21 21 CD cord-010092-uftc8inx 3440 4 Mirasoltreated Mirasoltreated NNP cord-010092-uftc8inx 3440 5 WB WB NNP cord-010092-uftc8inx 3440 6 transfusions transfusion NNS cord-010092-uftc8inx 3440 7 in in IN cord-010092-uftc8inx 3440 8 pregnant pregnant JJ cord-010092-uftc8inx 3440 9 women woman NNS cord-010092-uftc8inx 3440 10 and and CC cord-010092-uftc8inx 3440 11 2 2 CD cord-010092-uftc8inx 3440 12 TRARs trar NNS cord-010092-uftc8inx 3440 13 ( ( -LRB- cord-010092-uftc8inx 3440 14 9.5 9.5 CD cord-010092-uftc8inx 3440 15 % % NN cord-010092-uftc8inx 3440 16 ) ) -RRB- cord-010092-uftc8inx 3440 17 , , , cord-010092-uftc8inx 3440 18 both both DT cord-010092-uftc8inx 3440 19 Grade grade NN cord-010092-uftc8inx 3440 20 1 1 CD cord-010092-uftc8inx 3440 21 and and CC cord-010092-uftc8inx 3440 22 probably probably RB cord-010092-uftc8inx 3440 23 related related JJ cord-010092-uftc8inx 3440 24 . . . cord-010092-uftc8inx 3441 1 There there EX cord-010092-uftc8inx 3441 2 were be VBD cord-010092-uftc8inx 3441 3 80 80 CD cord-010092-uftc8inx 3441 4 transfusions transfusion NNS cord-010092-uftc8inx 3441 5 of of IN cord-010092-uftc8inx 3441 6 Mirasol Mirasol NNP cord-010092-uftc8inx 3441 7 - - HYPH cord-010092-uftc8inx 3441 8 treated treat VBN cord-010092-uftc8inx 3441 9 WB WB NNP cord-010092-uftc8inx 3441 10 and and CC cord-010092-uftc8inx 3441 11 84 84 CD cord-010092-uftc8inx 3441 12 transfusions transfusion NNS cord-010092-uftc8inx 3441 13 of of IN cord-010092-uftc8inx 3441 14 conventional conventional JJ cord-010092-uftc8inx 3441 15 WB WB NNP cord-010092-uftc8inx 3441 16 in in IN cord-010092-uftc8inx 3441 17 patients patient NNS cord-010092-uftc8inx 3441 18 < < XX cord-010092-uftc8inx 3441 19 18 18 CD cord-010092-uftc8inx 3441 20 years year NNS cord-010092-uftc8inx 3441 21 old old JJ cord-010092-uftc8inx 3441 22 resulting result VBG cord-010092-uftc8inx 3441 23 in in IN cord-010092-uftc8inx 3441 24 n n NN cord-010092-uftc8inx 3441 25 = = SYM cord-010092-uftc8inx 3441 26 7 7 CD cord-010092-uftc8inx 3441 27 ( ( -LRB- cord-010092-uftc8inx 3441 28 8.33 8.33 CD cord-010092-uftc8inx 3441 29 % % NN cord-010092-uftc8inx 3441 30 ) ) -RRB- cord-010092-uftc8inx 3441 31 TRARs trar NNS cord-010092-uftc8inx 3441 32 in in IN cord-010092-uftc8inx 3441 33 recipients recipient NNS cord-010092-uftc8inx 3441 34 of of IN cord-010092-uftc8inx 3441 35 Mirasol Mirasol NNP cord-010092-uftc8inx 3441 36 - - HYPH cord-010092-uftc8inx 3441 37 treated treat VBN cord-010092-uftc8inx 3441 38 WB WB NNP cord-010092-uftc8inx 3441 39 and and CC cord-010092-uftc8inx 3441 40 n n NN cord-010092-uftc8inx 3441 41 = = SYM cord-010092-uftc8inx 3441 42 10 10 CD cord-010092-uftc8inx 3441 43 ( ( -LRB- cord-010092-uftc8inx 3441 44 11.90 11.90 CD cord-010092-uftc8inx 3441 45 % % NN cord-010092-uftc8inx 3441 46 ) ) -RRB- cord-010092-uftc8inx 3441 47 in in IN cord-010092-uftc8inx 3441 48 recipients recipient NNS cord-010092-uftc8inx 3441 49 of of IN cord-010092-uftc8inx 3441 50 conventional conventional JJ cord-010092-uftc8inx 3441 51 WB WB NNP cord-010092-uftc8inx 3441 52 . . . cord-010092-uftc8inx 3442 1 Summary Summary NNP cord-010092-uftc8inx 3442 2 / / SYM cord-010092-uftc8inx 3442 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 3442 4 : : : cord-010092-uftc8inx 3443 1 Timely timely JJ cord-010092-uftc8inx 3443 2 data datum NNS cord-010092-uftc8inx 3443 3 reporting report VBG cord-010092-uftc8inx 3443 4 of of IN cord-010092-uftc8inx 3443 5 TRARs TRARs NNP cord-010092-uftc8inx 3443 6 and and CC cord-010092-uftc8inx 3443 7 expanding expand VBG cord-010092-uftc8inx 3443 8 the the DT cord-010092-uftc8inx 3443 9 HV HV NNP cord-010092-uftc8inx 3443 10 infrastructure infrastructure NN cord-010092-uftc8inx 3443 11 has have VBZ cord-010092-uftc8inx 3443 12 helped help VBN cord-010092-uftc8inx 3443 13 to to TO cord-010092-uftc8inx 3443 14 improve improve VB cord-010092-uftc8inx 3443 15 the the DT cord-010092-uftc8inx 3443 16 HV HV NNP cord-010092-uftc8inx 3443 17 system system NN cord-010092-uftc8inx 3443 18 in in IN cord-010092-uftc8inx 3443 19 Ghana Ghana NNP cord-010092-uftc8inx 3443 20 . . . cord-010092-uftc8inx 3444 1 Of of IN cord-010092-uftc8inx 3444 2 2181 2181 CD cord-010092-uftc8inx 3444 3 WB WB NNP cord-010092-uftc8inx 3444 4 transfusions transfusion NNS cord-010092-uftc8inx 3444 5 in in IN cord-010092-uftc8inx 3444 6 routine routine JJ cord-010092-uftc8inx 3444 7 use use NN cord-010092-uftc8inx 3444 8 in in IN cord-010092-uftc8inx 3444 9 Ghana Ghana NNP cord-010092-uftc8inx 3444 10 , , , cord-010092-uftc8inx 3444 11 there there EX cord-010092-uftc8inx 3444 12 were be VBD cord-010092-uftc8inx 3444 13 4.02 4.02 CD cord-010092-uftc8inx 3444 14 % % NN cord-010092-uftc8inx 3444 15 TRARs TRARs NNP cord-010092-uftc8inx 3444 16 in in IN cord-010092-uftc8inx 3444 17 recipients recipient NNS cord-010092-uftc8inx 3444 18 of of IN cord-010092-uftc8inx 3444 19 Mirasol Mirasol NNP cord-010092-uftc8inx 3444 20 - - HYPH cord-010092-uftc8inx 3444 21 treated treat VBN cord-010092-uftc8inx 3444 22 WB WB NNP cord-010092-uftc8inx 3444 23 and and CC cord-010092-uftc8inx 3444 24 5.59 5.59 CD cord-010092-uftc8inx 3444 25 % % NN cord-010092-uftc8inx 3444 26 in in IN cord-010092-uftc8inx 3444 27 recipients recipient NNS cord-010092-uftc8inx 3444 28 of of IN cord-010092-uftc8inx 3444 29 conventional conventional JJ cord-010092-uftc8inx 3444 30 WB WB NNP cord-010092-uftc8inx 3444 31 . . . cord-010092-uftc8inx 3445 1 Additionally additionally RB cord-010092-uftc8inx 3445 2 , , , cord-010092-uftc8inx 3445 3 Mirasol Mirasol NNP cord-010092-uftc8inx 3445 4 - - HYPH cord-010092-uftc8inx 3445 5 treated treat VBN cord-010092-uftc8inx 3445 6 WB WB NNP cord-010092-uftc8inx 3445 7 was be VBD cord-010092-uftc8inx 3445 8 safely safely RB cord-010092-uftc8inx 3445 9 transfused transfuse VBN cord-010092-uftc8inx 3445 10 in in IN cord-010092-uftc8inx 3445 11 pregnant pregnant JJ cord-010092-uftc8inx 3445 12 women woman NNS cord-010092-uftc8inx 3445 13 and and CC cord-010092-uftc8inx 3445 14 pediatric pediatric JJ cord-010092-uftc8inx 3445 15 patients patient NNS cord-010092-uftc8inx 3445 16 . . . cord-010092-uftc8inx 3446 1 Haematology Haematology NNP cord-010092-uftc8inx 3446 2 , , , cord-010092-uftc8inx 3446 3 Monash Monash NNP cord-010092-uftc8inx 3446 4 Health Health NNP cord-010092-uftc8inx 3446 5 , , , cord-010092-uftc8inx 3446 6 Melbourne Melbourne NNP cord-010092-uftc8inx 3446 7 , , , cord-010092-uftc8inx 3446 8 Australia Australia NNP cord-010092-uftc8inx 3446 9 Background Background NNP cord-010092-uftc8inx 3446 10 : : : cord-010092-uftc8inx 3446 11 Transfusion transfusion NN cord-010092-uftc8inx 3446 12 - - HYPH cord-010092-uftc8inx 3446 13 associated associate VBN cord-010092-uftc8inx 3446 14 graft graft NN cord-010092-uftc8inx 3446 15 - - HYPH cord-010092-uftc8inx 3446 16 versus versus IN cord-010092-uftc8inx 3446 17 - - HYPH cord-010092-uftc8inx 3446 18 host host NN cord-010092-uftc8inx 3446 19 disease disease NN cord-010092-uftc8inx 3447 1 ( ( -LRB- cord-010092-uftc8inx 3447 2 TA TA NNP cord-010092-uftc8inx 3447 3 - - HYPH cord-010092-uftc8inx 3447 4 GvHD GvHD NNP cord-010092-uftc8inx 3447 5 ) ) -RRB- cord-010092-uftc8inx 3447 6 is be VBZ cord-010092-uftc8inx 3447 7 rare rare JJ cord-010092-uftc8inx 3447 8 and and CC cord-010092-uftc8inx 3447 9 usually usually RB cord-010092-uftc8inx 3447 10 fatal fatal JJ cord-010092-uftc8inx 3447 11 . . . cord-010092-uftc8inx 3448 1 It -PRON- PRP cord-010092-uftc8inx 3448 2 can can MD cord-010092-uftc8inx 3448 3 be be VB cord-010092-uftc8inx 3448 4 prevented prevent VBN cord-010092-uftc8inx 3448 5 by by IN cord-010092-uftc8inx 3448 6 provision provision NN cord-010092-uftc8inx 3448 7 of of IN cord-010092-uftc8inx 3448 8 irradiated irradiate VBN cord-010092-uftc8inx 3448 9 blood blood NN cord-010092-uftc8inx 3448 10 products product NNS cord-010092-uftc8inx 3448 11 to to IN cord-010092-uftc8inx 3448 12 at at IN cord-010092-uftc8inx 3448 13 - - HYPH cord-010092-uftc8inx 3448 14 risk risk NN cord-010092-uftc8inx 3448 15 individuals individual NNS cord-010092-uftc8inx 3448 16 , , , cord-010092-uftc8inx 3448 17 such such JJ cord-010092-uftc8inx 3448 18 as as IN cord-010092-uftc8inx 3448 19 those those DT cord-010092-uftc8inx 3448 20 receiving receive VBG cord-010092-uftc8inx 3448 21 nucleoside nucleoside JJ cord-010092-uftc8inx 3448 22 analogues analogue NNS cord-010092-uftc8inx 3448 23 , , , cord-010092-uftc8inx 3448 24 alemtuzumab alemtuzumab NNS cord-010092-uftc8inx 3448 25 , , , cord-010092-uftc8inx 3448 26 bendamustine bendamustine NNP cord-010092-uftc8inx 3448 27 or or CC cord-010092-uftc8inx 3448 28 with with IN cord-010092-uftc8inx 3448 29 Hodgkin Hodgkin NNP cord-010092-uftc8inx 3448 30 lymphoma lymphoma NN cord-010092-uftc8inx 3448 31 ( ( -LRB- cord-010092-uftc8inx 3448 32 HL HL NNP cord-010092-uftc8inx 3448 33 ) ) -RRB- cord-010092-uftc8inx 3448 34 . . . cord-010092-uftc8inx 3449 1 Duration duration NN cord-010092-uftc8inx 3449 2 of of IN cord-010092-uftc8inx 3449 3 risk risk NN cord-010092-uftc8inx 3449 4 is be VBZ cord-010092-uftc8inx 3449 5 uncertain uncertain JJ cord-010092-uftc8inx 3449 6 , , , cord-010092-uftc8inx 3449 7 so so IN cord-010092-uftc8inx 3449 8 ensuring ensure VBG cord-010092-uftc8inx 3449 9 these these DT cord-010092-uftc8inx 3449 10 individuals individual NNS cord-010092-uftc8inx 3449 11 correctly correctly RB cord-010092-uftc8inx 3449 12 receive receive VBP cord-010092-uftc8inx 3449 13 lifelong lifelong JJ cord-010092-uftc8inx 3449 14 irradiated irradiate VBN cord-010092-uftc8inx 3449 15 blood blood NN cord-010092-uftc8inx 3449 16 components component NNS cord-010092-uftc8inx 3449 17 , , , cord-010092-uftc8inx 3449 18 as as IN cord-010092-uftc8inx 3449 19 currently currently RB cord-010092-uftc8inx 3449 20 recommended recommend VBN cord-010092-uftc8inx 3449 21 by by IN cord-010092-uftc8inx 3449 22 ANZSBT ANZSBT NNP cord-010092-uftc8inx 3449 23 and and CC cord-010092-uftc8inx 3449 24 BSH BSH NNP cord-010092-uftc8inx 3449 25 guidelines guideline NNS cord-010092-uftc8inx 3449 26 , , , cord-010092-uftc8inx 3449 27 is be VBZ cord-010092-uftc8inx 3449 28 challenging challenge VBG cord-010092-uftc8inx 3449 29 . . . cord-010092-uftc8inx 3450 1 In in IN cord-010092-uftc8inx 3450 2 Australia Australia NNP cord-010092-uftc8inx 3450 3 , , , cord-010092-uftc8inx 3450 4 platelets platelet NNS cord-010092-uftc8inx 3450 5 are be VBP cord-010092-uftc8inx 3450 6 routinely routinely RB cord-010092-uftc8inx 3450 7 irradiated irradiate VBN cord-010092-uftc8inx 3450 8 , , , cord-010092-uftc8inx 3450 9 but but CC cord-010092-uftc8inx 3450 10 red red JJ cord-010092-uftc8inx 3450 11 blood blood NN cord-010092-uftc8inx 3450 12 cells cell NNS cord-010092-uftc8inx 3450 13 ( ( -LRB- cord-010092-uftc8inx 3450 14 RBC RBC NNP cord-010092-uftc8inx 3450 15 ) ) -RRB- cord-010092-uftc8inx 3450 16 are be VBP cord-010092-uftc8inx 3450 17 not not RB cord-010092-uftc8inx 3450 18 . . . cord-010092-uftc8inx 3451 1 Aims aim VBZ cord-010092-uftc8inx 3451 2 : : : cord-010092-uftc8inx 3452 1 To to TO cord-010092-uftc8inx 3452 2 determine determine VB cord-010092-uftc8inx 3452 3 whether whether IN cord-010092-uftc8inx 3452 4 patients patient NNS cord-010092-uftc8inx 3452 5 receiving receive VBG cord-010092-uftc8inx 3452 6 fludarabine fludarabine NN cord-010092-uftc8inx 3452 7 , , , cord-010092-uftc8inx 3452 8 cladribine cladribine NNP cord-010092-uftc8inx 3452 9 , , , cord-010092-uftc8inx 3452 10 bendamustine bendamustine NNP cord-010092-uftc8inx 3452 11 , , , cord-010092-uftc8inx 3452 12 alemtuzumab alemtuzumab NNP cord-010092-uftc8inx 3452 13 , , , cord-010092-uftc8inx 3452 14 or or CC cord-010092-uftc8inx 3452 15 dacarbazine dacarbazine NNP cord-010092-uftc8inx 3452 16 ( ( -LRB- cord-010092-uftc8inx 3452 17 for for IN cord-010092-uftc8inx 3452 18 HL HL NNP cord-010092-uftc8inx 3452 19 ) ) -RRB- cord-010092-uftc8inx 3452 20 , , , cord-010092-uftc8inx 3452 21 appropriately appropriately RB cord-010092-uftc8inx 3452 22 received receive VBN cord-010092-uftc8inx 3452 23 irradiated irradiate VBN cord-010092-uftc8inx 3452 24 RBCs rbc NNS cord-010092-uftc8inx 3452 25 . . . cord-010092-uftc8inx 3453 1 Secondary secondary JJ cord-010092-uftc8inx 3453 2 outcomes outcome NNS cord-010092-uftc8inx 3453 3 included include VBD cord-010092-uftc8inx 3453 4 rates rate NNS cord-010092-uftc8inx 3453 5 of of IN cord-010092-uftc8inx 3453 6 TA TA NNP cord-010092-uftc8inx 3453 7 - - HYPH cord-010092-uftc8inx 3453 8 GvHD GvHD NNP cord-010092-uftc8inx 3453 9 after after IN cord-010092-uftc8inx 3453 10 unintended unintended JJ cord-010092-uftc8inx 3453 11 exposure exposure NN cord-010092-uftc8inx 3453 12 to to IN cord-010092-uftc8inx 3453 13 non non JJ cord-010092-uftc8inx 3453 14 - - JJ cord-010092-uftc8inx 3453 15 irradiated irradiate VBN cord-010092-uftc8inx 3453 16 components component NNS cord-010092-uftc8inx 3453 17 , , , cord-010092-uftc8inx 3453 18 factors factor NNS cord-010092-uftc8inx 3453 19 influencing influence VBG cord-010092-uftc8inx 3453 20 correct correct JJ cord-010092-uftc8inx 3453 21 issue issue NN cord-010092-uftc8inx 3453 22 of of IN cord-010092-uftc8inx 3453 23 irradiated irradiate VBN cord-010092-uftc8inx 3453 24 RBCs rbc NNS cord-010092-uftc8inx 3453 25 such such JJ cord-010092-uftc8inx 3453 26 as as IN cord-010092-uftc8inx 3453 27 transfusion transfusion NN cord-010092-uftc8inx 3453 28 management management NN cord-010092-uftc8inx 3453 29 plans plan NNS cord-010092-uftc8inx 3453 30 , , , cord-010092-uftc8inx 3453 31 and and CC cord-010092-uftc8inx 3453 32 provision provision NN cord-010092-uftc8inx 3453 33 of of IN cord-010092-uftc8inx 3453 34 adequate adequate JJ cord-010092-uftc8inx 3453 35 clinical clinical JJ cord-010092-uftc8inx 3453 36 information information NN cord-010092-uftc8inx 3453 37 on on IN cord-010092-uftc8inx 3453 38 blood blood NN cord-010092-uftc8inx 3453 39 requests request NNS cord-010092-uftc8inx 3453 40 . . . cord-010092-uftc8inx 3454 1 Methods method NNS cord-010092-uftc8inx 3454 2 : : : cord-010092-uftc8inx 3454 3 We -PRON- PRP cord-010092-uftc8inx 3454 4 performed perform VBD cord-010092-uftc8inx 3454 5 a a DT cord-010092-uftc8inx 3454 6 retrospective retrospective JJ cord-010092-uftc8inx 3454 7 audit audit NN cord-010092-uftc8inx 3454 8 to to TO cord-010092-uftc8inx 3454 9 identify identify VB cord-010092-uftc8inx 3454 10 patients patient NNS cord-010092-uftc8inx 3454 11 receiving receive VBG cord-010092-uftc8inx 3454 12 therapies therapy NNS cord-010092-uftc8inx 3454 13 indicating indicate VBG cord-010092-uftc8inx 3454 14 risk risk NN cord-010092-uftc8inx 3454 15 for for IN cord-010092-uftc8inx 3454 16 TA TA NNP cord-010092-uftc8inx 3454 17 - - HYPH cord-010092-uftc8inx 3454 18 GvHD GvHD NNP cord-010092-uftc8inx 3454 19 using use VBG cord-010092-uftc8inx 3454 20 pharmacy pharmacy NN cord-010092-uftc8inx 3454 21 dispensing dispense VBG cord-010092-uftc8inx 3454 22 records record NNS cord-010092-uftc8inx 3454 23 from from IN cord-010092-uftc8inx 3454 24 January January NNP cord-010092-uftc8inx 3454 25 2008 2008 CD cord-010092-uftc8inx 3454 26 to to IN cord-010092-uftc8inx 3454 27 October October NNP cord-010092-uftc8inx 3454 28 2018 2018 CD cord-010092-uftc8inx 3454 29 at at IN cord-010092-uftc8inx 3454 30 Monash Monash NNP cord-010092-uftc8inx 3454 31 Health Health NNP cord-010092-uftc8inx 3454 32 , , , cord-010092-uftc8inx 3454 33 a a DT cord-010092-uftc8inx 3454 34 multi multi JJ cord-010092-uftc8inx 3454 35 - - JJ cord-010092-uftc8inx 3454 36 campus campus JJ cord-010092-uftc8inx 3454 37 university university NN cord-010092-uftc8inx 3454 38 hospital hospital NN cord-010092-uftc8inx 3454 39 in in IN cord-010092-uftc8inx 3454 40 Melbourne Melbourne NNP cord-010092-uftc8inx 3454 41 , , , cord-010092-uftc8inx 3454 42 Australia Australia NNP cord-010092-uftc8inx 3454 43 . . . cord-010092-uftc8inx 3455 1 Diagnosis diagnosis NN cord-010092-uftc8inx 3455 2 , , , cord-010092-uftc8inx 3455 3 treatment treatment NN cord-010092-uftc8inx 3455 4 dates date NNS cord-010092-uftc8inx 3455 5 , , , cord-010092-uftc8inx 3455 6 group group NN cord-010092-uftc8inx 3455 7 and and CC cord-010092-uftc8inx 3455 8 hold hold VBP cord-010092-uftc8inx 3455 9 ( ( -LRB- cord-010092-uftc8inx 3455 10 G&H g&h NN cord-010092-uftc8inx 3455 11 ) ) -RRB- cord-010092-uftc8inx 3455 12 requests request NNS cord-010092-uftc8inx 3455 13 , , , cord-010092-uftc8inx 3455 14 RBC RBC NNP cord-010092-uftc8inx 3455 15 transfusions transfusion NNS cord-010092-uftc8inx 3455 16 , , , cord-010092-uftc8inx 3455 17 and and CC cord-010092-uftc8inx 3455 18 follow follow VB cord-010092-uftc8inx 3455 19 - - HYPH cord-010092-uftc8inx 3455 20 up up RP cord-010092-uftc8inx 3455 21 information information NN cord-010092-uftc8inx 3455 22 were be VBD cord-010092-uftc8inx 3455 23 sourced source VBN cord-010092-uftc8inx 3455 24 from from IN cord-010092-uftc8inx 3455 25 laboratory laboratory NN cord-010092-uftc8inx 3455 26 and and CC cord-010092-uftc8inx 3455 27 medical medical JJ cord-010092-uftc8inx 3455 28 records record NNS cord-010092-uftc8inx 3455 29 . . . cord-010092-uftc8inx 3456 1 Results result NNS cord-010092-uftc8inx 3456 2 : : : cord-010092-uftc8inx 3457 1 We -PRON- PRP cord-010092-uftc8inx 3457 2 identified identify VBD cord-010092-uftc8inx 3457 3 310 310 CD cord-010092-uftc8inx 3457 4 patients patient NNS cord-010092-uftc8inx 3457 5 who who WP cord-010092-uftc8inx 3457 6 received receive VBD cord-010092-uftc8inx 3457 7 fludarabine fludarabine NN cord-010092-uftc8inx 3457 8 ( ( -LRB- cord-010092-uftc8inx 3457 9 n n NN cord-010092-uftc8inx 3457 10 = = SYM cord-010092-uftc8inx 3457 11 52 52 CD cord-010092-uftc8inx 3457 12 , , , cord-010092-uftc8inx 3457 13 17 17 CD cord-010092-uftc8inx 3457 14 % % NN cord-010092-uftc8inx 3457 15 ) ) -RRB- cord-010092-uftc8inx 3457 16 , , , cord-010092-uftc8inx 3457 17 bendamustine bendamustine NNP cord-010092-uftc8inx 3457 18 ( ( -LRB- cord-010092-uftc8inx 3457 19 n n NN cord-010092-uftc8inx 3457 20 = = SYM cord-010092-uftc8inx 3457 21 29 29 CD cord-010092-uftc8inx 3457 22 , , , cord-010092-uftc8inx 3457 23 9 9 CD cord-010092-uftc8inx 3457 24 % % NN cord-010092-uftc8inx 3457 25 ) ) -RRB- cord-010092-uftc8inx 3457 26 , , , cord-010092-uftc8inx 3457 27 cladribine cladribine NNP cord-010092-uftc8inx 3457 28 ( ( -LRB- cord-010092-uftc8inx 3457 29 n n NN cord-010092-uftc8inx 3457 30 = = SYM cord-010092-uftc8inx 3457 31 17 17 CD cord-010092-uftc8inx 3457 32 , , , cord-010092-uftc8inx 3457 33 5 5 CD cord-010092-uftc8inx 3457 34 % % NN cord-010092-uftc8inx 3457 35 ) ) -RRB- cord-010092-uftc8inx 3457 36 , , , cord-010092-uftc8inx 3457 37 dacarbazine dacarbazine NNP cord-010092-uftc8inx 3457 38 for for IN cord-010092-uftc8inx 3457 39 HL HL NNP cord-010092-uftc8inx 3457 40 ( ( -LRB- cord-010092-uftc8inx 3457 41 n n NN cord-010092-uftc8inx 3457 42 = = SYM cord-010092-uftc8inx 3457 43 164 164 CD cord-010092-uftc8inx 3457 44 , , , cord-010092-uftc8inx 3457 45 53 53 CD cord-010092-uftc8inx 3457 46 % % NN cord-010092-uftc8inx 3457 47 ) ) -RRB- cord-010092-uftc8inx 3457 48 and and CC cord-010092-uftc8inx 3457 49 alemtuzumab alemtuzumab NNP cord-010092-uftc8inx 3457 50 ( ( -LRB- cord-010092-uftc8inx 3457 51 n n NN cord-010092-uftc8inx 3457 52 = = SYM cord-010092-uftc8inx 3457 53 48 48 CD cord-010092-uftc8inx 3457 54 , , , cord-010092-uftc8inx 3457 55 15 15 CD cord-010092-uftc8inx 3457 56 % % NN cord-010092-uftc8inx 3457 57 ) ) -RRB- cord-010092-uftc8inx 3457 58 . . . cord-010092-uftc8inx 3458 1 The the DT cord-010092-uftc8inx 3458 2 median median JJ cord-010092-uftc8inx 3458 3 age age NN cord-010092-uftc8inx 3458 4 of of IN cord-010092-uftc8inx 3458 5 patients patient NNS cord-010092-uftc8inx 3458 6 was be VBD cord-010092-uftc8inx 3458 7 46 46 CD cord-010092-uftc8inx 3458 8 years year NNS cord-010092-uftc8inx 3459 1 ( ( -LRB- cord-010092-uftc8inx 3459 2 range range NNP cord-010092-uftc8inx 3459 3 8 8 CD cord-010092-uftc8inx 3459 4 - - SYM cord-010092-uftc8inx 3459 5 92 92 CD cord-010092-uftc8inx 3459 6 ) ) -RRB- cord-010092-uftc8inx 3459 7 and and CC cord-010092-uftc8inx 3459 8 171 171 CD cord-010092-uftc8inx 3459 9 ( ( -LRB- cord-010092-uftc8inx 3459 10 55 55 CD cord-010092-uftc8inx 3459 11 % % NN cord-010092-uftc8inx 3459 12 ) ) -RRB- cord-010092-uftc8inx 3459 13 were be VBD cord-010092-uftc8inx 3459 14 male male JJ cord-010092-uftc8inx 3459 15 . . . cord-010092-uftc8inx 3460 1 Median median JJ cord-010092-uftc8inx 3460 2 follow follow NN cord-010092-uftc8inx 3460 3 - - HYPH cord-010092-uftc8inx 3460 4 up up NN cord-010092-uftc8inx 3460 5 was be VBD cord-010092-uftc8inx 3460 6 30 30 CD cord-010092-uftc8inx 3460 7 months month NNS cord-010092-uftc8inx 3461 1 ( ( -LRB- cord-010092-uftc8inx 3461 2 range range NN cord-010092-uftc8inx 3461 3 0 0 CD cord-010092-uftc8inx 3461 4 - - SYM cord-010092-uftc8inx 3461 5 132 132 CD cord-010092-uftc8inx 3461 6 ) ) -RRB- cord-010092-uftc8inx 3461 7 . . . cord-010092-uftc8inx 3462 1 Post post NN cord-010092-uftc8inx 3462 2 - - NN cord-010092-uftc8inx 3462 3 exposure exposure NN cord-010092-uftc8inx 3462 4 , , , cord-010092-uftc8inx 3462 5 42 42 CD cord-010092-uftc8inx 3462 6 patients patient NNS cord-010092-uftc8inx 3462 7 ( ( -LRB- cord-010092-uftc8inx 3462 8 14 14 CD cord-010092-uftc8inx 3462 9 % % NN cord-010092-uftc8inx 3462 10 ) ) -RRB- cord-010092-uftc8inx 3462 11 received receive VBD cord-010092-uftc8inx 3462 12 transfusions transfusion NNS cord-010092-uftc8inx 3462 13 with with IN cord-010092-uftc8inx 3462 14 33 33 CD cord-010092-uftc8inx 3462 15 % % NN cord-010092-uftc8inx 3462 16 correctly correctly RB cord-010092-uftc8inx 3462 17 receiving receive VBG cord-010092-uftc8inx 3462 18 irradiated irradiate VBN cord-010092-uftc8inx 3462 19 RBCs rbc NNS cord-010092-uftc8inx 3462 20 . . . cord-010092-uftc8inx 3463 1 The the DT cord-010092-uftc8inx 3463 2 remaining remain VBG cord-010092-uftc8inx 3463 3 28 28 CD cord-010092-uftc8inx 3463 4 , , , cord-010092-uftc8inx 3463 5 all all DT cord-010092-uftc8inx 3463 6 from from IN cord-010092-uftc8inx 3463 7 haematology haematology NNP cord-010092-uftc8inx 3463 8 / / SYM cord-010092-uftc8inx 3463 9 oncology oncology NN cord-010092-uftc8inx 3463 10 , , , cord-010092-uftc8inx 3463 11 received receive VBD cord-010092-uftc8inx 3463 12 a a DT cord-010092-uftc8inx 3463 13 total total NN cord-010092-uftc8inx 3463 14 of of IN cord-010092-uftc8inx 3463 15 192 192 CD cord-010092-uftc8inx 3463 16 unirradiated unirradiated JJ cord-010092-uftc8inx 3463 17 RBCs rbc NNS cord-010092-uftc8inx 3463 18 . . . cord-010092-uftc8inx 3464 1 In in IN cord-010092-uftc8inx 3464 2 8 8 CD cord-010092-uftc8inx 3464 3 patients patient NNS cord-010092-uftc8inx 3464 4 , , , cord-010092-uftc8inx 3464 5 this this DT cord-010092-uftc8inx 3464 6 was be VBD cord-010092-uftc8inx 3464 7 rectified rectify VBN cord-010092-uftc8inx 3464 8 on on IN cord-010092-uftc8inx 3464 9 subsequent subsequent JJ cord-010092-uftc8inx 3464 10 transfusions transfusion NNS cord-010092-uftc8inx 3464 11 . . . cord-010092-uftc8inx 3465 1 There there EX cord-010092-uftc8inx 3465 2 were be VBD cord-010092-uftc8inx 3465 3 no no DT cord-010092-uftc8inx 3465 4 cases case NNS cord-010092-uftc8inx 3465 5 of of IN cord-010092-uftc8inx 3465 6 TA TA NNP cord-010092-uftc8inx 3465 7 - - HYPH cord-010092-uftc8inx 3465 8 GvHD GvHD NNP cord-010092-uftc8inx 3465 9 at at IN cord-010092-uftc8inx 3465 10 median median JJ cord-010092-uftc8inx 3465 11 follow follow NN cord-010092-uftc8inx 3465 12 - - HYPH cord-010092-uftc8inx 3465 13 up up NN cord-010092-uftc8inx 3465 14 of of IN cord-010092-uftc8inx 3465 15 14.5 14.5 CD cord-010092-uftc8inx 3465 16 months month NNS cord-010092-uftc8inx 3466 1 ( ( -LRB- cord-010092-uftc8inx 3466 2 range range NN cord-010092-uftc8inx 3466 3 0 0 CD cord-010092-uftc8inx 3466 4 - - SYM cord-010092-uftc8inx 3466 5 75 75 CD cord-010092-uftc8inx 3466 6 ) ) -RRB- cord-010092-uftc8inx 3466 7 from from IN cord-010092-uftc8inx 3466 8 first first JJ cord-010092-uftc8inx 3466 9 RBC RBC NNP cord-010092-uftc8inx 3466 10 transfusion transfusion NN cord-010092-uftc8inx 3466 11 . . . cord-010092-uftc8inx 3467 1 After after IN cord-010092-uftc8inx 3467 2 medication medication NN cord-010092-uftc8inx 3467 3 administration administration NN cord-010092-uftc8inx 3467 4 , , , cord-010092-uftc8inx 3467 5 99 99 CD cord-010092-uftc8inx 3467 6 patients patient NNS cord-010092-uftc8inx 3467 7 had have VBD cord-010092-uftc8inx 3467 8 G&H g&h NN cord-010092-uftc8inx 3467 9 requests request NNS cord-010092-uftc8inx 3467 10 after after IN cord-010092-uftc8inx 3467 11 a a DT cord-010092-uftc8inx 3467 12 median median NN cord-010092-uftc8inx 3467 13 of of IN cord-010092-uftc8inx 3467 14 3 3 CD cord-010092-uftc8inx 3467 15 months month NNS cord-010092-uftc8inx 3467 16 ( ( -LRB- cord-010092-uftc8inx 3467 17 range range VBP cord-010092-uftc8inx 3467 18 0 0 CD cord-010092-uftc8inx 3467 19 - - SYM cord-010092-uftc8inx 3467 20 129 129 CD cord-010092-uftc8inx 3467 21 ) ) -RRB- cord-010092-uftc8inx 3467 22 . . . cord-010092-uftc8inx 3468 1 Only only RB cord-010092-uftc8inx 3468 2 23 23 CD cord-010092-uftc8inx 3468 3 % % NN cord-010092-uftc8inx 3468 4 of of IN cord-010092-uftc8inx 3468 5 requests request NNS cord-010092-uftc8inx 3468 6 had have VBD cord-010092-uftc8inx 3468 7 sufficient sufficient JJ cord-010092-uftc8inx 3468 8 clinical clinical JJ cord-010092-uftc8inx 3468 9 information information NN cord-010092-uftc8inx 3468 10 to to IN cord-010092-uftc8inx 3468 11 prompt prompt JJ cord-010092-uftc8inx 3468 12 irradiation irradiation NN cord-010092-uftc8inx 3468 13 , , , cord-010092-uftc8inx 3468 14 such such JJ cord-010092-uftc8inx 3468 15 as as IN cord-010092-uftc8inx 3468 16 HL HL NNP cord-010092-uftc8inx 3468 17 or or CC cord-010092-uftc8inx 3468 18 medication medication NN cord-010092-uftc8inx 3468 19 details detail NNS cord-010092-uftc8inx 3468 20 , , , cord-010092-uftc8inx 3468 21 and and CC cord-010092-uftc8inx 3468 22 only only RB cord-010092-uftc8inx 3468 23 20 20 CD cord-010092-uftc8inx 3468 24 % % NN cord-010092-uftc8inx 3468 25 asked ask VBN cord-010092-uftc8inx 3468 26 for for IN cord-010092-uftc8inx 3468 27 irradiated irradiate VBN cord-010092-uftc8inx 3468 28 components component NNS cord-010092-uftc8inx 3468 29 . . . cord-010092-uftc8inx 3469 1 Preventive preventive JJ cord-010092-uftc8inx 3469 2 strategies strategy NNS cord-010092-uftc8inx 3469 3 have have VBP cord-010092-uftc8inx 3469 4 now now RB cord-010092-uftc8inx 3469 5 been be VBN cord-010092-uftc8inx 3469 6 employed employ VBN cord-010092-uftc8inx 3469 7 . . . cord-010092-uftc8inx 3470 1 Transfusion transfusion NN cord-010092-uftc8inx 3470 2 management management NN cord-010092-uftc8inx 3470 3 plans plan VBZ cord-010092-uftc8inx 3470 4 for for IN cord-010092-uftc8inx 3470 5 haematology haematology NN cord-010092-uftc8inx 3470 6 patients patient NNS cord-010092-uftc8inx 3470 7 were be VBD cord-010092-uftc8inx 3470 8 implemented implement VBN cord-010092-uftc8inx 3470 9 in in IN cord-010092-uftc8inx 3470 10 March March NNP cord-010092-uftc8inx 3470 11 2017 2017 CD cord-010092-uftc8inx 3470 12 . . . cord-010092-uftc8inx 3471 1 For for IN cord-010092-uftc8inx 3471 2 audited audit VBN cord-010092-uftc8inx 3471 3 patients patient NNS cord-010092-uftc8inx 3471 4 , , , cord-010092-uftc8inx 3471 5 these these DT cord-010092-uftc8inx 3471 6 were be VBD cord-010092-uftc8inx 3471 7 written write VBN cord-010092-uftc8inx 3471 8 from from IN cord-010092-uftc8inx 3471 9 38 38 CD cord-010092-uftc8inx 3471 10 days day NNS cord-010092-uftc8inx 3471 11 prior prior RB cord-010092-uftc8inx 3471 12 to to IN cord-010092-uftc8inx 3471 13 104 104 CD cord-010092-uftc8inx 3471 14 days day NNS cord-010092-uftc8inx 3471 15 after after IN cord-010092-uftc8inx 3471 16 medication medication NN cord-010092-uftc8inx 3471 17 exposure exposure NN cord-010092-uftc8inx 3471 18 . . . cord-010092-uftc8inx 3472 1 Two two CD cord-010092-uftc8inx 3472 2 were be VBD cord-010092-uftc8inx 3472 3 written write VBN cord-010092-uftc8inx 3472 4 following follow VBG cord-010092-uftc8inx 3472 5 inadvertent inadvertent JJ cord-010092-uftc8inx 3472 6 unirradiated unirradiate VBN cord-010092-uftc8inx 3472 7 RBC RBC NNP cord-010092-uftc8inx 3472 8 transfusion transfusion NN cord-010092-uftc8inx 3472 9 . . . cord-010092-uftc8inx 3473 1 Patients patient NNS cord-010092-uftc8inx 3473 2 identified identify VBN cord-010092-uftc8inx 3473 3 in in IN cord-010092-uftc8inx 3473 4 this this DT cord-010092-uftc8inx 3473 5 audit audit NN cord-010092-uftc8inx 3473 6 will will MD cord-010092-uftc8inx 3473 7 have have VB cord-010092-uftc8inx 3473 8 a a DT cord-010092-uftc8inx 3473 9 laboratory laboratory NN cord-010092-uftc8inx 3473 10 flag flag NN cord-010092-uftc8inx 3473 11 generated generate VBN cord-010092-uftc8inx 3473 12 and and CC cord-010092-uftc8inx 3473 13 prospectively prospectively RB cord-010092-uftc8inx 3473 14 , , , cord-010092-uftc8inx 3473 15 pharmacy pharmacy NN cord-010092-uftc8inx 3473 16 dispensing dispense VBG cord-010092-uftc8inx 3473 17 records record NNS cord-010092-uftc8inx 3473 18 will will MD cord-010092-uftc8inx 3473 19 be be VB cord-010092-uftc8inx 3473 20 sent send VBN cord-010092-uftc8inx 3473 21 to to IN cord-010092-uftc8inx 3473 22 blood blood NN cord-010092-uftc8inx 3473 23 bank bank NN cord-010092-uftc8inx 3473 24 to to TO cord-010092-uftc8inx 3473 25 identify identify VB cord-010092-uftc8inx 3473 26 at at IN cord-010092-uftc8inx 3473 27 - - HYPH cord-010092-uftc8inx 3473 28 risk risk NN cord-010092-uftc8inx 3473 29 patients patient NNS cord-010092-uftc8inx 3473 30 . . . cord-010092-uftc8inx 3474 1 Our -PRON- PRP$ cord-010092-uftc8inx 3474 2 hospital hospital NN cord-010092-uftc8inx 3474 3 is be VBZ cord-010092-uftc8inx 3474 4 transitioning transition VBG cord-010092-uftc8inx 3474 5 to to IN cord-010092-uftc8inx 3474 6 electronic electronic JJ cord-010092-uftc8inx 3474 7 medical medical JJ cord-010092-uftc8inx 3474 8 records record NNS cord-010092-uftc8inx 3474 9 ( ( -LRB- cord-010092-uftc8inx 3474 10 EMR EMR NNP cord-010092-uftc8inx 3474 11 ) ) -RRB- cord-010092-uftc8inx 3474 12 . . . cord-010092-uftc8inx 3475 1 An an DT cord-010092-uftc8inx 3475 2 alert alert NN cord-010092-uftc8inx 3475 3 will will MD cord-010092-uftc8inx 3475 4 be be VB cord-010092-uftc8inx 3475 5 generated generate VBN cord-010092-uftc8inx 3475 6 in in IN cord-010092-uftc8inx 3475 7 EMR EMR NNP cord-010092-uftc8inx 3475 8 when when WRB cord-010092-uftc8inx 3475 9 ordering order VBG cord-010092-uftc8inx 3475 10 transfusions transfusion NNS cord-010092-uftc8inx 3475 11 if if IN cord-010092-uftc8inx 3475 12 there there EX cord-010092-uftc8inx 3475 13 has have VBZ cord-010092-uftc8inx 3475 14 been be VBN cord-010092-uftc8inx 3475 15 exposure exposure NN cord-010092-uftc8inx 3475 16 to to IN cord-010092-uftc8inx 3475 17 these these DT cord-010092-uftc8inx 3475 18 medications medication NNS cord-010092-uftc8inx 3475 19 . . . cord-010092-uftc8inx 3476 1 However however RB cord-010092-uftc8inx 3476 2 , , , cord-010092-uftc8inx 3476 3 clinical clinical JJ cord-010092-uftc8inx 3476 4 awareness awareness NN cord-010092-uftc8inx 3476 5 and and CC cord-010092-uftc8inx 3476 6 documentation documentation NN cord-010092-uftc8inx 3476 7 remain remain VBP cord-010092-uftc8inx 3476 8 vital vital JJ cord-010092-uftc8inx 3476 9 . . . cord-010092-uftc8inx 3477 1 Additional additional JJ cord-010092-uftc8inx 3477 2 measures measure NNS cord-010092-uftc8inx 3477 3 include include VBP cord-010092-uftc8inx 3477 4 patient patient JJ cord-010092-uftc8inx 3477 5 education education NN cord-010092-uftc8inx 3477 6 , , , cord-010092-uftc8inx 3477 7 alert alert NN cord-010092-uftc8inx 3477 8 cards card NNS cord-010092-uftc8inx 3477 9 , , , cord-010092-uftc8inx 3477 10 and and CC cord-010092-uftc8inx 3477 11 ongoing ongoing JJ cord-010092-uftc8inx 3477 12 collaboration collaboration NN cord-010092-uftc8inx 3477 13 with with IN cord-010092-uftc8inx 3477 14 medical medical JJ cord-010092-uftc8inx 3477 15 staff staff NN cord-010092-uftc8inx 3477 16 to to TO cord-010092-uftc8inx 3477 17 encourage encourage VB cord-010092-uftc8inx 3477 18 transfusion transfusion NN cord-010092-uftc8inx 3477 19 planning planning NN cord-010092-uftc8inx 3477 20 . . . cord-010092-uftc8inx 3478 1 Summary Summary NNP cord-010092-uftc8inx 3478 2 / / SYM cord-010092-uftc8inx 3478 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 3478 4 : : : cord-010092-uftc8inx 3479 1 Recognition recognition NN cord-010092-uftc8inx 3479 2 of of IN cord-010092-uftc8inx 3479 3 patients patient NNS cord-010092-uftc8inx 3479 4 at at IN cord-010092-uftc8inx 3479 5 risk risk NN cord-010092-uftc8inx 3479 6 for for IN cord-010092-uftc8inx 3479 7 TA TA NNP cord-010092-uftc8inx 3479 8 - - HYPH cord-010092-uftc8inx 3479 9 GvHD GvHD NNP cord-010092-uftc8inx 3479 10 remains remain VBZ cord-010092-uftc8inx 3479 11 low low JJ cord-010092-uftc8inx 3479 12 , , , cord-010092-uftc8inx 3479 13 even even RB cord-010092-uftc8inx 3479 14 among among IN cord-010092-uftc8inx 3479 15 haematology haematology NN cord-010092-uftc8inx 3479 16 units unit NNS cord-010092-uftc8inx 3479 17 . . . cord-010092-uftc8inx 3480 1 We -PRON- PRP cord-010092-uftc8inx 3480 2 are be VBP cord-010092-uftc8inx 3480 3 making make VBG cord-010092-uftc8inx 3480 4 progress progress NN cord-010092-uftc8inx 3480 5 on on IN cord-010092-uftc8inx 3480 6 ensuring ensure VBG cord-010092-uftc8inx 3480 7 provision provision NN cord-010092-uftc8inx 3480 8 of of IN cord-010092-uftc8inx 3480 9 lifelong lifelong JJ cord-010092-uftc8inx 3480 10 irradiated irradiate VBN cord-010092-uftc8inx 3480 11 blood blood NN cord-010092-uftc8inx 3480 12 components component NNS cord-010092-uftc8inx 3480 13 in in IN cord-010092-uftc8inx 3480 14 patients patient NNS cord-010092-uftc8inx 3480 15 exposed expose VBN cord-010092-uftc8inx 3480 16 to to IN cord-010092-uftc8inx 3480 17 nucleoside nucleoside JJ cord-010092-uftc8inx 3480 18 analogues analogue NNS cord-010092-uftc8inx 3480 19 or or CC cord-010092-uftc8inx 3480 20 alemtuzumab alemtuzumab NNS cord-010092-uftc8inx 3480 21 , , , cord-010092-uftc8inx 3480 22 as as RB cord-010092-uftc8inx 3480 23 well well RB cord-010092-uftc8inx 3480 24 as as IN cord-010092-uftc8inx 3480 25 HL HL NNP cord-010092-uftc8inx 3480 26 patients patient NNS cord-010092-uftc8inx 3480 27 . . . cord-010092-uftc8inx 3481 1 Implementation implementation NN cord-010092-uftc8inx 3481 2 of of IN cord-010092-uftc8inx 3481 3 an an DT cord-010092-uftc8inx 3481 4 EMR EMR NNP cord-010092-uftc8inx 3481 5 and and CC cord-010092-uftc8inx 3481 6 additional additional JJ cord-010092-uftc8inx 3481 7 strategies strategy NNS cord-010092-uftc8inx 3481 8 in in IN cord-010092-uftc8inx 3481 9 this this DT cord-010092-uftc8inx 3481 10 domain domain NN cord-010092-uftc8inx 3481 11 is be VBZ cord-010092-uftc8inx 3481 12 important important JJ cord-010092-uftc8inx 3481 13 to to TO cord-010092-uftc8inx 3481 14 prevent prevent VB cord-010092-uftc8inx 3481 15 TA TA NNP cord-010092-uftc8inx 3481 16 - - HYPH cord-010092-uftc8inx 3481 17 GvHD GvHD NNP cord-010092-uftc8inx 3481 18 . . . cord-010092-uftc8inx 3482 1 Background background NN cord-010092-uftc8inx 3482 2 : : : cord-010092-uftc8inx 3483 1 Blood blood NN cord-010092-uftc8inx 3483 2 transfusion transfusion NN cord-010092-uftc8inx 3483 3 is be VBZ cord-010092-uftc8inx 3483 4 considered consider VBN cord-010092-uftc8inx 3483 5 an an DT cord-010092-uftc8inx 3483 6 essential essential JJ cord-010092-uftc8inx 3483 7 element element NN cord-010092-uftc8inx 3483 8 in in IN cord-010092-uftc8inx 3483 9 the the DT cord-010092-uftc8inx 3483 10 management management NN cord-010092-uftc8inx 3483 11 of of IN cord-010092-uftc8inx 3483 12 patients patient NNS cord-010092-uftc8inx 3483 13 globally globally RB cord-010092-uftc8inx 3483 14 . . . cord-010092-uftc8inx 3484 1 It -PRON- PRP cord-010092-uftc8inx 3484 2 might may MD cord-010092-uftc8inx 3484 3 be be VB cord-010092-uftc8inx 3484 4 risky risky JJ cord-010092-uftc8inx 3484 5 and and CC cord-010092-uftc8inx 3484 6 transfusion transfusion NN cord-010092-uftc8inx 3484 7 related relate VBD cord-010092-uftc8inx 3484 8 adverse adverse JJ cord-010092-uftc8inx 3484 9 reactions reaction NNS cord-010092-uftc8inx 3484 10 may may MD cord-010092-uftc8inx 3484 11 occur occur VB cord-010092-uftc8inx 3484 12 with with IN cord-010092-uftc8inx 3484 13 the the DT cord-010092-uftc8inx 3484 14 less less JJR cord-010092-uftc8inx 3484 15 adherence adherence NN cord-010092-uftc8inx 3484 16 of of IN cord-010092-uftc8inx 3484 17 transfusion transfusion NN cord-010092-uftc8inx 3484 18 policies policy NNS cord-010092-uftc8inx 3484 19 . . . cord-010092-uftc8inx 3485 1 Standard standard JJ cord-010092-uftc8inx 3485 2 guidelines guideline NNS cord-010092-uftc8inx 3485 3 regarding regard VBG cord-010092-uftc8inx 3485 4 the the DT cord-010092-uftc8inx 3485 5 screening screening NN cord-010092-uftc8inx 3485 6 of of IN cord-010092-uftc8inx 3485 7 blood blood NN cord-010092-uftc8inx 3485 8 for for IN cord-010092-uftc8inx 3485 9 infectious infectious JJ cord-010092-uftc8inx 3485 10 disease disease NN cord-010092-uftc8inx 3485 11 , , , cord-010092-uftc8inx 3485 12 genuine genuine JJ cord-010092-uftc8inx 3485 13 need need NN cord-010092-uftc8inx 3485 14 of of IN cord-010092-uftc8inx 3485 15 transfusion transfusion NN cord-010092-uftc8inx 3485 16 and and CC cord-010092-uftc8inx 3485 17 ABO ABO NNP cord-010092-uftc8inx 3485 18 compatibility compatibility NN cord-010092-uftc8inx 3485 19 are be VBP cord-010092-uftc8inx 3485 20 followed follow VBN cord-010092-uftc8inx 3485 21 and and CC cord-010092-uftc8inx 3485 22 monitored monitor VBN cord-010092-uftc8inx 3485 23 drastically drastically RB cord-010092-uftc8inx 3485 24 . . . cord-010092-uftc8inx 3486 1 However however RB cord-010092-uftc8inx 3486 2 , , , cord-010092-uftc8inx 3486 3 patient patient JJ cord-010092-uftc8inx 3486 4 assessment assessment NN cord-010092-uftc8inx 3486 5 during during IN cord-010092-uftc8inx 3486 6 transfusion transfusion NN cord-010092-uftc8inx 3486 7 especially especially RB cord-010092-uftc8inx 3486 8 at at IN cord-010092-uftc8inx 3486 9 patient patient JJ cord-010092-uftc8inx 3486 10 bedside bedside NN cord-010092-uftc8inx 3486 11 and and CC cord-010092-uftc8inx 3486 12 post post NN cord-010092-uftc8inx 3486 13 transfusion transfusion NN cord-010092-uftc8inx 3486 14 is be VBZ cord-010092-uftc8inx 3486 15 also also RB cord-010092-uftc8inx 3486 16 equally equally RB cord-010092-uftc8inx 3486 17 important important JJ cord-010092-uftc8inx 3486 18 . . . cord-010092-uftc8inx 3487 1 Aims aim VBZ cord-010092-uftc8inx 3487 2 : : : cord-010092-uftc8inx 3487 3 We -PRON- PRP cord-010092-uftc8inx 3487 4 are be VBP cord-010092-uftc8inx 3487 5 a a DT cord-010092-uftc8inx 3487 6 newly newly RB cord-010092-uftc8inx 3487 7 established establish VBN cord-010092-uftc8inx 3487 8 hospital hospital NN cord-010092-uftc8inx 3487 9 and and CC cord-010092-uftc8inx 3487 10 are be VBP cord-010092-uftc8inx 3487 11 working work VBG cord-010092-uftc8inx 3487 12 towards towards IN cord-010092-uftc8inx 3487 13 the the DT cord-010092-uftc8inx 3487 14 best good JJS cord-010092-uftc8inx 3487 15 possible possible JJ cord-010092-uftc8inx 3487 16 management management NN cord-010092-uftc8inx 3487 17 of of IN cord-010092-uftc8inx 3487 18 patients patient NNS cord-010092-uftc8inx 3487 19 . . . cord-010092-uftc8inx 3488 1 In in IN cord-010092-uftc8inx 3488 2 this this DT cord-010092-uftc8inx 3488 3 regard regard NN cord-010092-uftc8inx 3488 4 to to TO cord-010092-uftc8inx 3488 5 minimize minimize VB cord-010092-uftc8inx 3488 6 the the DT cord-010092-uftc8inx 3488 7 transfusion transfusion NN cord-010092-uftc8inx 3488 8 errors error NNS cord-010092-uftc8inx 3488 9 and and CC cord-010092-uftc8inx 3488 10 to to TO cord-010092-uftc8inx 3488 11 highlight highlight VB cord-010092-uftc8inx 3488 12 if if IN cord-010092-uftc8inx 3488 13 any any DT cord-010092-uftc8inx 3488 14 lacking lack VBG cord-010092-uftc8inx 3488 15 being be VBG cord-010092-uftc8inx 3488 16 practiced practice VBN cord-010092-uftc8inx 3488 17 during during IN cord-010092-uftc8inx 3488 18 transfusion transfusion NN cord-010092-uftc8inx 3488 19 , , , cord-010092-uftc8inx 3488 20 we -PRON- PRP cord-010092-uftc8inx 3488 21 conducted conduct VBD cord-010092-uftc8inx 3488 22 this this DT cord-010092-uftc8inx 3488 23 study study NN cord-010092-uftc8inx 3488 24 to to TO cord-010092-uftc8inx 3488 25 observe observe VB cord-010092-uftc8inx 3488 26 the the DT cord-010092-uftc8inx 3488 27 compliance compliance NN cord-010092-uftc8inx 3488 28 rate rate NN cord-010092-uftc8inx 3488 29 of of IN cord-010092-uftc8inx 3488 30 documentation documentation NN cord-010092-uftc8inx 3488 31 of of IN cord-010092-uftc8inx 3488 32 transfusion transfusion NN cord-010092-uftc8inx 3488 33 form form NN cord-010092-uftc8inx 3488 34 by by IN cord-010092-uftc8inx 3488 35 the the DT cord-010092-uftc8inx 3488 36 healthcare healthcare NN cord-010092-uftc8inx 3488 37 staff staff NN cord-010092-uftc8inx 3488 38 and and CC cord-010092-uftc8inx 3488 39 also also RB cord-010092-uftc8inx 3488 40 to to TO cord-010092-uftc8inx 3488 41 observe observe VB cord-010092-uftc8inx 3488 42 the the DT cord-010092-uftc8inx 3488 43 compliance compliance NN cord-010092-uftc8inx 3488 44 of of IN cord-010092-uftc8inx 3488 45 line line NN cord-010092-uftc8inx 3488 46 of of IN cord-010092-uftc8inx 3488 47 action action NN cord-010092-uftc8inx 3488 48 taken take VBN cord-010092-uftc8inx 3488 49 in in IN cord-010092-uftc8inx 3488 50 case case NN cord-010092-uftc8inx 3488 51 of of IN cord-010092-uftc8inx 3488 52 occurrence occurrence NN cord-010092-uftc8inx 3488 53 of of IN cord-010092-uftc8inx 3488 54 transfusion transfusion NN cord-010092-uftc8inx 3488 55 reactions reaction NNS cord-010092-uftc8inx 3488 56 . . . cord-010092-uftc8inx 3489 1 Methods method NNS cord-010092-uftc8inx 3489 2 : : : cord-010092-uftc8inx 3489 3 This this DT cord-010092-uftc8inx 3489 4 was be VBD cord-010092-uftc8inx 3489 5 a a DT cord-010092-uftc8inx 3489 6 observational observational JJ cord-010092-uftc8inx 3489 7 study study NN cord-010092-uftc8inx 3489 8 conducted conduct VBN cord-010092-uftc8inx 3489 9 at at IN cord-010092-uftc8inx 3489 10 NIBD NIBD NNP cord-010092-uftc8inx 3489 11 and and CC cord-010092-uftc8inx 3489 12 BMT BMT NNP cord-010092-uftc8inx 3489 13 , , , cord-010092-uftc8inx 3489 14 PECHS PECHS NNP cord-010092-uftc8inx 3489 15 campus campus NN cord-010092-uftc8inx 3489 16 from from IN cord-010092-uftc8inx 3489 17 February February NNP cord-010092-uftc8inx 3489 18 2018 2018 CD cord-010092-uftc8inx 3489 19 to to IN cord-010092-uftc8inx 3489 20 February February NNP cord-010092-uftc8inx 3489 21 2019 2019 CD cord-010092-uftc8inx 3489 22 . . . cord-010092-uftc8inx 3490 1 Ethical ethical JJ cord-010092-uftc8inx 3490 2 approval approval NN cord-010092-uftc8inx 3490 3 was be VBD cord-010092-uftc8inx 3490 4 obtained obtain VBN cord-010092-uftc8inx 3490 5 prior prior RB cord-010092-uftc8inx 3490 6 to to IN cord-010092-uftc8inx 3490 7 the the DT cord-010092-uftc8inx 3490 8 study study NN cord-010092-uftc8inx 3490 9 . . . cord-010092-uftc8inx 3491 1 Transfusion transfusion NN cord-010092-uftc8inx 3491 2 form form NN cord-010092-uftc8inx 3491 3 for for IN cord-010092-uftc8inx 3491 4 each each DT cord-010092-uftc8inx 3491 5 transfusion transfusion NN cord-010092-uftc8inx 3491 6 was be VBD cord-010092-uftc8inx 3491 7 filled fill VBN cord-010092-uftc8inx 3491 8 . . . cord-010092-uftc8inx 3492 1 The the DT cord-010092-uftc8inx 3492 2 form form NN cord-010092-uftc8inx 3492 3 provided provide VBD cord-010092-uftc8inx 3492 4 information information NN cord-010092-uftc8inx 3492 5 on on IN cord-010092-uftc8inx 3492 6 documentation documentation NN cord-010092-uftc8inx 3492 7 of of IN cord-010092-uftc8inx 3492 8 blood blood NN cord-010092-uftc8inx 3492 9 product product NN cord-010092-uftc8inx 3492 10 receiver receiver NN cord-010092-uftc8inx 3492 11 name name NN cord-010092-uftc8inx 3492 12 , , , cord-010092-uftc8inx 3492 13 employee employee NN cord-010092-uftc8inx 3492 14 identity identity NN cord-010092-uftc8inx 3492 15 number number NN cord-010092-uftc8inx 3492 16 , , , cord-010092-uftc8inx 3492 17 date date NN cord-010092-uftc8inx 3492 18 and and CC cord-010092-uftc8inx 3492 19 time time NN cord-010092-uftc8inx 3492 20 of of IN cord-010092-uftc8inx 3492 21 receiving receive VBG cord-010092-uftc8inx 3492 22 blood blood NN cord-010092-uftc8inx 3492 23 product product NN cord-010092-uftc8inx 3492 24 , , , cord-010092-uftc8inx 3492 25 patient patient JJ cord-010092-uftc8inx 3492 26 name name NN cord-010092-uftc8inx 3492 27 , , , cord-010092-uftc8inx 3492 28 medical medical JJ cord-010092-uftc8inx 3492 29 record record NN cord-010092-uftc8inx 3492 30 number number NN cord-010092-uftc8inx 3492 31 on on IN cord-010092-uftc8inx 3492 32 units unit NNS cord-010092-uftc8inx 3492 33 , , , cord-010092-uftc8inx 3492 34 on on IN cord-010092-uftc8inx 3492 35 patient patient NN cord-010092-uftc8inx 3492 36 's 's POS cord-010092-uftc8inx 3492 37 wrist wrist NN cord-010092-uftc8inx 3492 38 band band NN cord-010092-uftc8inx 3492 39 and and CC cord-010092-uftc8inx 3492 40 on on IN cord-010092-uftc8inx 3492 41 transfusion transfusion NN cord-010092-uftc8inx 3492 42 form form NN cord-010092-uftc8inx 3492 43 . . . cord-010092-uftc8inx 3493 1 ABO ABO NNP cord-010092-uftc8inx 3493 2 compatibility compatibility NN cord-010092-uftc8inx 3493 3 on on IN cord-010092-uftc8inx 3493 4 the the DT cord-010092-uftc8inx 3493 5 unit unit NN cord-010092-uftc8inx 3493 6 and and CC cord-010092-uftc8inx 3493 7 on on IN cord-010092-uftc8inx 3493 8 form form NN cord-010092-uftc8inx 3493 9 , , , cord-010092-uftc8inx 3493 10 medical medical JJ cord-010092-uftc8inx 3493 11 record record NN cord-010092-uftc8inx 3493 12 number number NN cord-010092-uftc8inx 3493 13 from from IN cord-010092-uftc8inx 3493 14 wrist wrist NN cord-010092-uftc8inx 3493 15 band band NN cord-010092-uftc8inx 3493 16 , , , cord-010092-uftc8inx 3493 17 name name NN cord-010092-uftc8inx 3493 18 and and CC cord-010092-uftc8inx 3493 19 employee employee NN cord-010092-uftc8inx 3493 20 identity identity NN cord-010092-uftc8inx 3493 21 number number NN cord-010092-uftc8inx 3493 22 of of IN cord-010092-uftc8inx 3493 23 two two CD cord-010092-uftc8inx 3493 24 healthcare healthcare NN cord-010092-uftc8inx 3493 25 staff staff NN cord-010092-uftc8inx 3493 26 started start VBD cord-010092-uftc8inx 3493 27 transfusion transfusion NN cord-010092-uftc8inx 3493 28 , , , cord-010092-uftc8inx 3493 29 transfusion transfusion NN cord-010092-uftc8inx 3493 30 start start NN cord-010092-uftc8inx 3493 31 and and CC cord-010092-uftc8inx 3493 32 completion completion NN cord-010092-uftc8inx 3493 33 time time NN cord-010092-uftc8inx 3493 34 . . . cord-010092-uftc8inx 3494 1 Time time NN cord-010092-uftc8inx 3494 2 , , , cord-010092-uftc8inx 3494 3 temperature temperature NN cord-010092-uftc8inx 3494 4 , , , cord-010092-uftc8inx 3494 5 blood blood NN cord-010092-uftc8inx 3494 6 pressure pressure NN cord-010092-uftc8inx 3494 7 , , , cord-010092-uftc8inx 3494 8 pulse pulse NN cord-010092-uftc8inx 3494 9 and and CC cord-010092-uftc8inx 3494 10 initials initial NNS cord-010092-uftc8inx 3494 11 of of IN cord-010092-uftc8inx 3494 12 staff staff NN cord-010092-uftc8inx 3494 13 at at IN cord-010092-uftc8inx 3494 14 the the DT cord-010092-uftc8inx 3494 15 time time NN cord-010092-uftc8inx 3494 16 of of IN cord-010092-uftc8inx 3494 17 order order NN cord-010092-uftc8inx 3494 18 , , , cord-010092-uftc8inx 3494 19 onset onset NN cord-010092-uftc8inx 3494 20 , , , cord-010092-uftc8inx 3494 21 after after IN cord-010092-uftc8inx 3494 22 15 15 CD cord-010092-uftc8inx 3494 23 minutes minute NNS cord-010092-uftc8inx 3494 24 and and CC cord-010092-uftc8inx 3494 25 at at IN cord-010092-uftc8inx 3494 26 the the DT cord-010092-uftc8inx 3494 27 completion completion NN cord-010092-uftc8inx 3494 28 of of IN cord-010092-uftc8inx 3494 29 transfusion transfusion NN cord-010092-uftc8inx 3494 30 were be VBD cord-010092-uftc8inx 3494 31 also also RB cord-010092-uftc8inx 3494 32 included include VBN cord-010092-uftc8inx 3494 33 . . . cord-010092-uftc8inx 3495 1 Transfusion transfusion NN cord-010092-uftc8inx 3495 2 reaction reaction NN cord-010092-uftc8inx 3495 3 form form NN cord-010092-uftc8inx 3495 4 was be VBD cord-010092-uftc8inx 3495 5 also also RB cord-010092-uftc8inx 3495 6 filled fill VBN cord-010092-uftc8inx 3495 7 by by IN cord-010092-uftc8inx 3495 8 the the DT cord-010092-uftc8inx 3495 9 healthcare healthcare NN cord-010092-uftc8inx 3495 10 staff staff NN cord-010092-uftc8inx 3495 11 . . . cord-010092-uftc8inx 3496 1 Data datum NNS cord-010092-uftc8inx 3496 2 was be VBD cord-010092-uftc8inx 3496 3 analyzed analyze VBN cord-010092-uftc8inx 3496 4 by by IN cord-010092-uftc8inx 3496 5 using use VBG cord-010092-uftc8inx 3496 6 SPSS SPSS NNP cord-010092-uftc8inx 3496 7 version version NN cord-010092-uftc8inx 3496 8 23.0 23.0 CD cord-010092-uftc8inx 3496 9 . . . cord-010092-uftc8inx 3497 1 Results result NNS cord-010092-uftc8inx 3497 2 : : : cord-010092-uftc8inx 3498 1 A a DT cord-010092-uftc8inx 3498 2 total total NN cord-010092-uftc8inx 3498 3 of of IN cord-010092-uftc8inx 3498 4 500 500 CD cord-010092-uftc8inx 3498 5 transfusions transfusion NNS cord-010092-uftc8inx 3498 6 forms form NNS cord-010092-uftc8inx 3498 7 were be VBD cord-010092-uftc8inx 3498 8 analyzed analyze VBN cord-010092-uftc8inx 3498 9 . . . cord-010092-uftc8inx 3499 1 Over over IN cord-010092-uftc8inx 3499 2 all all DT cord-010092-uftc8inx 3499 3 compliance compliance NN cord-010092-uftc8inx 3499 4 rate rate NN cord-010092-uftc8inx 3499 5 was be VBD cord-010092-uftc8inx 3499 6 18 18 CD cord-010092-uftc8inx 3499 7 % % NN cord-010092-uftc8inx 3499 8 . . . cord-010092-uftc8inx 3500 1 Out out IN cord-010092-uftc8inx 3500 2 of of IN cord-010092-uftc8inx 3500 3 500 500 CD cord-010092-uftc8inx 3500 4 , , , cord-010092-uftc8inx 3500 5 115(23 115(23 CD cord-010092-uftc8inx 3500 6 % % NN cord-010092-uftc8inx 3500 7 ) ) -RRB- cord-010092-uftc8inx 3500 8 forms form NNS cord-010092-uftc8inx 3500 9 were be VBD cord-010092-uftc8inx 3500 10 available available JJ cord-010092-uftc8inx 3500 11 in in IN cord-010092-uftc8inx 3500 12 source source NN cord-010092-uftc8inx 3500 13 notes note NNS cord-010092-uftc8inx 3500 14 and and CC cord-010092-uftc8inx 3500 15 of of IN cord-010092-uftc8inx 3500 16 115 115 CD cord-010092-uftc8inx 3500 17 , , , cord-010092-uftc8inx 3500 18 88 88 CD cord-010092-uftc8inx 3500 19 ( ( -LRB- cord-010092-uftc8inx 3500 20 76 76 CD cord-010092-uftc8inx 3500 21 % % NN cord-010092-uftc8inx 3500 22 ) ) -RRB- cord-010092-uftc8inx 3500 23 were be VBD cord-010092-uftc8inx 3500 24 partially partially RB cord-010092-uftc8inx 3500 25 and and CC cord-010092-uftc8inx 3500 26 completely completely RB cord-010092-uftc8inx 3500 27 filled fill VBN cord-010092-uftc8inx 3500 28 . . . cord-010092-uftc8inx 3501 1 Higher high JJR cord-010092-uftc8inx 3501 2 compliance compliance NN cord-010092-uftc8inx 3501 3 was be VBD cord-010092-uftc8inx 3501 4 seen see VBN cord-010092-uftc8inx 3501 5 in in IN cord-010092-uftc8inx 3501 6 the the DT cord-010092-uftc8inx 3501 7 initial initial JJ cord-010092-uftc8inx 3501 8 months month NNS cord-010092-uftc8inx 3501 9 of of IN cord-010092-uftc8inx 3501 10 hospital hospital NN cord-010092-uftc8inx 3501 11 establishment establishment NN cord-010092-uftc8inx 3501 12 than than IN cord-010092-uftc8inx 3501 13 later later JJ cord-010092-uftc8inx 3501 14 months month NNS cord-010092-uftc8inx 3501 15 ( ( -LRB- cord-010092-uftc8inx 3501 16 P p NN cord-010092-uftc8inx 3501 17 - - HYPH cord-010092-uftc8inx 3501 18 value value NN cord-010092-uftc8inx 3501 19 = = SYM cord-010092-uftc8inx 3501 20 0.000 0.000 CD cord-010092-uftc8inx 3501 21 ) ) -RRB- cord-010092-uftc8inx 3501 22 . . . cord-010092-uftc8inx 3502 1 Highest high JJS cord-010092-uftc8inx 3502 2 non non JJ cord-010092-uftc8inx 3502 3 compliance compliance NN cord-010092-uftc8inx 3502 4 was be VBD cord-010092-uftc8inx 3502 5 seen see VBN cord-010092-uftc8inx 3502 6 in in IN cord-010092-uftc8inx 3502 7 documentation documentation NN cord-010092-uftc8inx 3502 8 of of IN cord-010092-uftc8inx 3502 9 initials initial NNS cord-010092-uftc8inx 3502 10 of of IN cord-010092-uftc8inx 3502 11 duty duty NN cord-010092-uftc8inx 3502 12 doctors doctor NNS cord-010092-uftc8inx 3502 13 on on IN cord-010092-uftc8inx 3502 14 transfusion transfusion NN cord-010092-uftc8inx 3502 15 form form NN cord-010092-uftc8inx 3502 16 at at IN cord-010092-uftc8inx 3502 17 the the DT cord-010092-uftc8inx 3502 18 completion completion NN cord-010092-uftc8inx 3502 19 of of IN cord-010092-uftc8inx 3502 20 transfusion(3 transfusion(3 CD cord-010092-uftc8inx 3502 21 % % NN cord-010092-uftc8inx 3502 22 ) ) -RRB- cord-010092-uftc8inx 3502 23 and and CC cord-010092-uftc8inx 3502 24 highest high JJS cord-010092-uftc8inx 3502 25 compliance compliance NN cord-010092-uftc8inx 3502 26 was be VBD cord-010092-uftc8inx 3502 27 seen see VBN cord-010092-uftc8inx 3502 28 in in IN cord-010092-uftc8inx 3502 29 documentation documentation NN cord-010092-uftc8inx 3502 30 of of IN cord-010092-uftc8inx 3502 31 name name NN cord-010092-uftc8inx 3502 32 by by IN cord-010092-uftc8inx 3502 33 healthcare healthcare NN cord-010092-uftc8inx 3502 34 nursing nursing NN cord-010092-uftc8inx 3502 35 staff staff NN cord-010092-uftc8inx 3502 36 at at IN cord-010092-uftc8inx 3502 37 the the DT cord-010092-uftc8inx 3502 38 start start NN cord-010092-uftc8inx 3502 39 of of IN cord-010092-uftc8inx 3502 40 transfusion(89 transfusion(89 NNP cord-010092-uftc8inx 3502 41 % % NN cord-010092-uftc8inx 3502 42 ) ) -RRB- cord-010092-uftc8inx 3502 43 . . . cord-010092-uftc8inx 3503 1 A a DT cord-010092-uftc8inx 3503 2 total total NN cord-010092-uftc8inx 3503 3 of of IN cord-010092-uftc8inx 3503 4 02(0.4 02(0.4 CD cord-010092-uftc8inx 3503 5 % % NN cord-010092-uftc8inx 3503 6 ) ) -RRB- cord-010092-uftc8inx 3504 1 adverse adverse JJ cord-010092-uftc8inx 3504 2 events event NNS cord-010092-uftc8inx 3504 3 were be VBD cord-010092-uftc8inx 3504 4 reported report VBN cord-010092-uftc8inx 3504 5 from from IN cord-010092-uftc8inx 3504 6 red red JJ cord-010092-uftc8inx 3504 7 blood blood NN cord-010092-uftc8inx 3504 8 cells cell NNS cord-010092-uftc8inx 3504 9 and and CC cord-010092-uftc8inx 3504 10 platelets platelet NNS cord-010092-uftc8inx 3504 11 . . . cord-010092-uftc8inx 3505 1 Mean mean JJ cord-010092-uftc8inx 3505 2 time time NN cord-010092-uftc8inx 3505 3 of of IN cord-010092-uftc8inx 3505 4 start start NN cord-010092-uftc8inx 3505 5 of of IN cord-010092-uftc8inx 3505 6 symptoms symptom NNS cord-010092-uftc8inx 3505 7 was be VBD cord-010092-uftc8inx 3505 8 2 2 CD cord-010092-uftc8inx 3505 9 hours hour NNS cord-010092-uftc8inx 3505 10 and and CC cord-010092-uftc8inx 3505 11 30 30 CD cord-010092-uftc8inx 3505 12 minutes minute NNS cord-010092-uftc8inx 3505 13 for for IN cord-010092-uftc8inx 3505 14 red red JJ cord-010092-uftc8inx 3505 15 blood blood NN cord-010092-uftc8inx 3505 16 cells cell NNS cord-010092-uftc8inx 3505 17 and and CC cord-010092-uftc8inx 3505 18 for for IN cord-010092-uftc8inx 3505 19 platelets platelet NNS cord-010092-uftc8inx 3505 20 it -PRON- PRP cord-010092-uftc8inx 3505 21 was be VBD cord-010092-uftc8inx 3505 22 1 1 CD cord-010092-uftc8inx 3505 23 hour hour NN cord-010092-uftc8inx 3505 24 and and CC cord-010092-uftc8inx 3505 25 13 13 CD cord-010092-uftc8inx 3505 26 minutes minute NNS cord-010092-uftc8inx 3505 27 . . . cord-010092-uftc8inx 3506 1 Transfusion transfusion NN cord-010092-uftc8inx 3506 2 was be VBD cord-010092-uftc8inx 3506 3 instantly instantly RB cord-010092-uftc8inx 3506 4 stopped stop VBN cord-010092-uftc8inx 3506 5 as as IN cord-010092-uftc8inx 3506 6 the the DT cord-010092-uftc8inx 3506 7 symptoms symptom NNS cord-010092-uftc8inx 3506 8 appeared appear VBD cord-010092-uftc8inx 3506 9 with with IN cord-010092-uftc8inx 3506 10 no no DT cord-010092-uftc8inx 3506 11 delay delay NN cord-010092-uftc8inx 3506 12 of of IN cord-010092-uftc8inx 3506 13 time time NN cord-010092-uftc8inx 3506 14 and and CC cord-010092-uftc8inx 3506 15 actions action NNS cord-010092-uftc8inx 3506 16 were be VBD cord-010092-uftc8inx 3506 17 taken take VBN cord-010092-uftc8inx 3506 18 to to TO cord-010092-uftc8inx 3506 19 resolve resolve VB cord-010092-uftc8inx 3506 20 the the DT cord-010092-uftc8inx 3506 21 reactions reaction NNS cord-010092-uftc8inx 3506 22 . . . cord-010092-uftc8inx 3507 1 Time time NN cord-010092-uftc8inx 3507 2 of of IN cord-010092-uftc8inx 3507 3 appearance appearance NN cord-010092-uftc8inx 3507 4 of of IN cord-010092-uftc8inx 3507 5 symptoms symptom NNS cord-010092-uftc8inx 3507 6 and and CC cord-010092-uftc8inx 3507 7 time time NN cord-010092-uftc8inx 3507 8 of of IN cord-010092-uftc8inx 3507 9 start start NN cord-010092-uftc8inx 3507 10 of of IN cord-010092-uftc8inx 3507 11 medication medication NN cord-010092-uftc8inx 3507 12 were be VBD cord-010092-uftc8inx 3507 13 documented document VBN cord-010092-uftc8inx 3507 14 and and CC cord-010092-uftc8inx 3507 15 error error NN cord-010092-uftc8inx 3507 16 free free JJ cord-010092-uftc8inx 3507 17 . . . cord-010092-uftc8inx 3508 1 All all DT cord-010092-uftc8inx 3508 2 blood blood NN cord-010092-uftc8inx 3508 3 bags bag NNS cord-010092-uftc8inx 3508 4 were be VBD cord-010092-uftc8inx 3508 5 returned return VBN cord-010092-uftc8inx 3508 6 to to IN cord-010092-uftc8inx 3508 7 the the DT cord-010092-uftc8inx 3508 8 blood blood NN cord-010092-uftc8inx 3508 9 bank bank NN cord-010092-uftc8inx 3508 10 and and CC cord-010092-uftc8inx 3508 11 discarded discard VBN cord-010092-uftc8inx 3508 12 after after IN cord-010092-uftc8inx 3508 13 6 6 CD cord-010092-uftc8inx 3508 14 hours hour NNS cord-010092-uftc8inx 3508 15 as as IN cord-010092-uftc8inx 3508 16 per per IN cord-010092-uftc8inx 3508 17 the the DT cord-010092-uftc8inx 3508 18 policy policy NN cord-010092-uftc8inx 3508 19 of of IN cord-010092-uftc8inx 3508 20 hospital hospital NN cord-010092-uftc8inx 3508 21 . . . cord-010092-uftc8inx 3509 1 Summary Summary NNP cord-010092-uftc8inx 3509 2 / / SYM cord-010092-uftc8inx 3509 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 3509 4 : : : cord-010092-uftc8inx 3510 1 The the DT cord-010092-uftc8inx 3510 2 study study NN cord-010092-uftc8inx 3510 3 was be VBD cord-010092-uftc8inx 3510 4 conducted conduct VBN cord-010092-uftc8inx 3510 5 to to TO cord-010092-uftc8inx 3510 6 highlight highlight VB cord-010092-uftc8inx 3510 7 the the DT cord-010092-uftc8inx 3510 8 scarce scarce JJ cord-010092-uftc8inx 3510 9 practices practice NNS cord-010092-uftc8inx 3510 10 that that WDT cord-010092-uftc8inx 3510 11 are be VBP cord-010092-uftc8inx 3510 12 being be VBG cord-010092-uftc8inx 3510 13 implemented implement VBN cord-010092-uftc8inx 3510 14 by by IN cord-010092-uftc8inx 3510 15 healthcare healthcare NN cord-010092-uftc8inx 3510 16 staff staff NN cord-010092-uftc8inx 3510 17 in in IN cord-010092-uftc8inx 3510 18 context context NN cord-010092-uftc8inx 3510 19 of of IN cord-010092-uftc8inx 3510 20 documentation documentation NN cord-010092-uftc8inx 3510 21 and and CC cord-010092-uftc8inx 3510 22 reporting reporting NN cord-010092-uftc8inx 3510 23 of of IN cord-010092-uftc8inx 3510 24 transfusion transfusion NN cord-010092-uftc8inx 3510 25 reactions reaction NNS cord-010092-uftc8inx 3510 26 at at IN cord-010092-uftc8inx 3510 27 our -PRON- PRP$ cord-010092-uftc8inx 3510 28 hospital hospital NN cord-010092-uftc8inx 3510 29 . . . cord-010092-uftc8inx 3511 1 Stringent stringent JJ cord-010092-uftc8inx 3511 2 actions action NNS cord-010092-uftc8inx 3511 3 should should MD cord-010092-uftc8inx 3511 4 be be VB cord-010092-uftc8inx 3511 5 taken take VBN cord-010092-uftc8inx 3511 6 for for IN cord-010092-uftc8inx 3511 7 the the DT cord-010092-uftc8inx 3511 8 adherence adherence NN cord-010092-uftc8inx 3511 9 of of IN cord-010092-uftc8inx 3511 10 compliance compliance NN cord-010092-uftc8inx 3511 11 by by IN cord-010092-uftc8inx 3511 12 healthcare healthcare NN cord-010092-uftc8inx 3511 13 staff staff NN cord-010092-uftc8inx 3511 14 to to TO cord-010092-uftc8inx 3511 15 avoid avoid VB cord-010092-uftc8inx 3511 16 morbidities morbidity NNS cord-010092-uftc8inx 3511 17 and and CC cord-010092-uftc8inx 3511 18 mortalities mortality NNS cord-010092-uftc8inx 3511 19 . . . cord-010092-uftc8inx 3512 1 We -PRON- PRP cord-010092-uftc8inx 3512 2 believe believe VBP cord-010092-uftc8inx 3512 3 that that IN cord-010092-uftc8inx 3512 4 it -PRON- PRP cord-010092-uftc8inx 3512 5 will will MD cord-010092-uftc8inx 3512 6 also also RB cord-010092-uftc8inx 3512 7 be be VB cord-010092-uftc8inx 3512 8 helpful helpful JJ cord-010092-uftc8inx 3512 9 to to TO cord-010092-uftc8inx 3512 10 provide provide VB cord-010092-uftc8inx 3512 11 baseline baseline JJ cord-010092-uftc8inx 3512 12 information information NN cord-010092-uftc8inx 3512 13 in in IN cord-010092-uftc8inx 3512 14 the the DT cord-010092-uftc8inx 3512 15 process process NN cord-010092-uftc8inx 3512 16 of of IN cord-010092-uftc8inx 3512 17 preparation preparation NN cord-010092-uftc8inx 3512 18 of of IN cord-010092-uftc8inx 3512 19 a a DT cord-010092-uftc8inx 3512 20 national national JJ cord-010092-uftc8inx 3512 21 guidelines guideline NNS cord-010092-uftc8inx 3512 22 and and CC cord-010092-uftc8inx 3512 23 protocol protocol NN cord-010092-uftc8inx 3512 24 on on IN cord-010092-uftc8inx 3512 25 blood blood NN cord-010092-uftc8inx 3512 26 transfusion transfusion NN cord-010092-uftc8inx 3512 27 procedures procedure NNS cord-010092-uftc8inx 3512 28 . . . cord-010092-uftc8inx 3513 1 5A 5a CD cord-010092-uftc8inx 3513 2 - - HYPH cord-010092-uftc8inx 3513 3 S31 S31 NNP cord-010092-uftc8inx 3513 4 - - HYPH cord-010092-uftc8inx 3513 5 01 01 CD cord-010092-uftc8inx 3514 1 AS as IN cord-010092-uftc8inx 3514 2 Buser Buser NNP cord-010092-uftc8inx 3514 3 , , , cord-010092-uftc8inx 3514 4 A a DT cord-010092-uftc8inx 3514 5 Holbro Holbro NNP cord-010092-uftc8inx 3514 6 and and CC cord-010092-uftc8inx 3514 7 L L NNP cord-010092-uftc8inx 3514 8 Infanti Infanti NNP cord-010092-uftc8inx 3514 9 Regional Regional NNP cord-010092-uftc8inx 3514 10 Blood Blood NNP cord-010092-uftc8inx 3514 11 Transfusion Transfusion NNP cord-010092-uftc8inx 3514 12 Service Service NNP cord-010092-uftc8inx 3514 13 , , , cord-010092-uftc8inx 3514 14 Swiss Swiss NNP cord-010092-uftc8inx 3514 15 Red Red NNP cord-010092-uftc8inx 3514 16 Cross Cross NNP cord-010092-uftc8inx 3514 17 , , , cord-010092-uftc8inx 3514 18 Basel Basel NNP cord-010092-uftc8inx 3514 19 , , , cord-010092-uftc8inx 3514 20 Basel Basel NNP cord-010092-uftc8inx 3514 21 , , , cord-010092-uftc8inx 3514 22 Switzerland Switzerland NNP cord-010092-uftc8inx 3515 1 To to TO cord-010092-uftc8inx 3515 2 make make VB cord-010092-uftc8inx 3515 3 blood blood NN cord-010092-uftc8inx 3515 4 supply supply NN cord-010092-uftc8inx 3515 5 safer safe JJR cord-010092-uftc8inx 3515 6 , , , cord-010092-uftc8inx 3515 7 pathogen pathogen NN cord-010092-uftc8inx 3515 8 inactivation inactivation NN cord-010092-uftc8inx 3515 9 ( ( -LRB- cord-010092-uftc8inx 3515 10 PI PI NNP cord-010092-uftc8inx 3515 11 ) ) -RRB- cord-010092-uftc8inx 3515 12 technologies technology NNS cord-010092-uftc8inx 3515 13 have have VBP cord-010092-uftc8inx 3515 14 been be VBN cord-010092-uftc8inx 3515 15 developed develop VBN cord-010092-uftc8inx 3515 16 . . . cord-010092-uftc8inx 3516 1 They -PRON- PRP cord-010092-uftc8inx 3516 2 are be VBP cord-010092-uftc8inx 3516 3 based base VBN cord-010092-uftc8inx 3516 4 on on IN cord-010092-uftc8inx 3516 5 photochemical photochemical JJ cord-010092-uftc8inx 3516 6 ( ( -LRB- cord-010092-uftc8inx 3516 7 amotosalen amotosalen NNP cord-010092-uftc8inx 3516 8 / / SYM cord-010092-uftc8inx 3516 9 UVA UVA NNP cord-010092-uftc8inx 3516 10 or or CC cord-010092-uftc8inx 3516 11 riboflavin/ riboflavin/ NNP cord-010092-uftc8inx 3516 12 UV uv NN cord-010092-uftc8inx 3516 13 ) ) -RRB- cord-010092-uftc8inx 3516 14 or or CC cord-010092-uftc8inx 3516 15 UV uv NN cord-010092-uftc8inx 3516 16 - - HYPH cord-010092-uftc8inx 3516 17 C c NN cord-010092-uftc8inx 3516 18 light light NN cord-010092-uftc8inx 3516 19 treatment treatment NN cord-010092-uftc8inx 3516 20 to to TO cord-010092-uftc8inx 3516 21 reduce reduce VB cord-010092-uftc8inx 3516 22 potential potential JJ cord-010092-uftc8inx 3516 23 pathogens pathogen NNS cord-010092-uftc8inx 3516 24 in in IN cord-010092-uftc8inx 3516 25 blood blood NN cord-010092-uftc8inx 3516 26 components component NNS cord-010092-uftc8inx 3516 27 . . . cord-010092-uftc8inx 3517 1 This this DT cord-010092-uftc8inx 3517 2 gain gain NN cord-010092-uftc8inx 3517 3 of of IN cord-010092-uftc8inx 3517 4 safety safety NN cord-010092-uftc8inx 3517 5 might may MD cord-010092-uftc8inx 3517 6 however however RB cord-010092-uftc8inx 3517 7 be be VB cord-010092-uftc8inx 3517 8 offset offset VBN cord-010092-uftc8inx 3517 9 by by IN cord-010092-uftc8inx 3517 10 " " `` cord-010092-uftc8inx 3517 11 off off IN cord-010092-uftc8inx 3517 12 target target NN cord-010092-uftc8inx 3517 13 " " '' cord-010092-uftc8inx 3517 14 effects effect NNS cord-010092-uftc8inx 3517 15 of of IN cord-010092-uftc8inx 3517 16 these these DT cord-010092-uftc8inx 3517 17 technologies technology NNS cord-010092-uftc8inx 3517 18 . . . cord-010092-uftc8inx 3518 1 In in IN cord-010092-uftc8inx 3518 2 virtually virtually RB cord-010092-uftc8inx 3518 3 all all DT cord-010092-uftc8inx 3518 4 clinical clinical JJ cord-010092-uftc8inx 3518 5 platelet platelet NN cord-010092-uftc8inx 3518 6 transfusion transfusion NN cord-010092-uftc8inx 3518 7 trials trial NNS cord-010092-uftc8inx 3518 8 , , , cord-010092-uftc8inx 3518 9 it -PRON- PRP cord-010092-uftc8inx 3518 10 has have VBZ cord-010092-uftc8inx 3518 11 been be VBN cord-010092-uftc8inx 3518 12 demonstrated demonstrate VBN cord-010092-uftc8inx 3518 13 that that IN cord-010092-uftc8inx 3518 14 post post NN cord-010092-uftc8inx 3518 15 transfusion transfusion NN cord-010092-uftc8inx 3518 16 increments increment NNS cord-010092-uftc8inx 3518 17 with with IN cord-010092-uftc8inx 3518 18 PI pi NN cord-010092-uftc8inx 3518 19 platelet platelet NN cord-010092-uftc8inx 3518 20 ( ( -LRB- cord-010092-uftc8inx 3518 21 PLT PLT NNP cord-010092-uftc8inx 3518 22 ) ) -RRB- cord-010092-uftc8inx 3518 23 components component NNS cord-010092-uftc8inx 3518 24 are be VBP cord-010092-uftc8inx 3518 25 lower low JJR cord-010092-uftc8inx 3518 26 as as IN cord-010092-uftc8inx 3518 27 compared compare VBN cord-010092-uftc8inx 3518 28 to to IN cord-010092-uftc8inx 3518 29 conventional conventional JJ cord-010092-uftc8inx 3518 30 components component NNS cord-010092-uftc8inx 3518 31 , , , cord-010092-uftc8inx 3518 32 indicating indicate VBG cord-010092-uftc8inx 3518 33 different different JJ cord-010092-uftc8inx 3518 34 biological biological JJ cord-010092-uftc8inx 3518 35 behaviour behaviour NN cord-010092-uftc8inx 3518 36 such such JJ cord-010092-uftc8inx 3518 37 as as IN cord-010092-uftc8inx 3518 38 survival/ survival/ JJ cord-010092-uftc8inx 3518 39 clearance clearance NN cord-010092-uftc8inx 3518 40 of of IN cord-010092-uftc8inx 3518 41 nontreated nontreated JJ cord-010092-uftc8inx 3518 42 and and CC cord-010092-uftc8inx 3518 43 treated treat VBD cord-010092-uftc8inx 3518 44 PLT PLT NNP cord-010092-uftc8inx 3518 45 . . . cord-010092-uftc8inx 3519 1 Published publish VBN cord-010092-uftc8inx 3519 2 studies study NNS cord-010092-uftc8inx 3519 3 have have VBP cord-010092-uftc8inx 3519 4 also also RB cord-010092-uftc8inx 3519 5 suggested suggest VBN cord-010092-uftc8inx 3519 6 shorter short JJR cord-010092-uftc8inx 3519 7 survival survival NN cord-010092-uftc8inx 3519 8 of of IN cord-010092-uftc8inx 3519 9 platelets platelet NNS cord-010092-uftc8inx 3519 10 in in IN cord-010092-uftc8inx 3519 11 vivo vivo NN cord-010092-uftc8inx 3519 12 in in IN cord-010092-uftc8inx 3519 13 animal animal NN cord-010092-uftc8inx 3519 14 studies study NNS cord-010092-uftc8inx 3519 15 . . . cord-010092-uftc8inx 3520 1 Additionally additionally RB cord-010092-uftc8inx 3520 2 , , , cord-010092-uftc8inx 3520 3 data datum NNS cord-010092-uftc8inx 3520 4 of of IN cord-010092-uftc8inx 3520 5 the the DT cord-010092-uftc8inx 3520 6 rates rate NNS cord-010092-uftc8inx 3520 7 of of IN cord-010092-uftc8inx 3520 8 alloimmunization alloimmunization NN cord-010092-uftc8inx 3520 9 and and CC cord-010092-uftc8inx 3520 10 refractoriness refractoriness NN cord-010092-uftc8inx 3520 11 after after IN cord-010092-uftc8inx 3520 12 transfusion transfusion NN cord-010092-uftc8inx 3520 13 of of IN cord-010092-uftc8inx 3520 14 PI pi NN cord-010092-uftc8inx 3520 15 platelets platelet NNS cord-010092-uftc8inx 3520 16 are be VBP cord-010092-uftc8inx 3520 17 show show VBP cord-010092-uftc8inx 3520 18 discrepant discrepant JJ cord-010092-uftc8inx 3520 19 results result NNS cord-010092-uftc8inx 3520 20 . . . cord-010092-uftc8inx 3521 1 Animal animal NN cord-010092-uftc8inx 3521 2 studies study NNS cord-010092-uftc8inx 3521 3 suggest suggest VBP cord-010092-uftc8inx 3521 4 a a DT cord-010092-uftc8inx 3521 5 reduction reduction NN cord-010092-uftc8inx 3521 6 of of IN cord-010092-uftc8inx 3521 7 the the DT cord-010092-uftc8inx 3521 8 rates rate NNS cord-010092-uftc8inx 3521 9 of of IN cord-010092-uftc8inx 3521 10 alloimmunization alloimmunization NN cord-010092-uftc8inx 3521 11 when when WRB cord-010092-uftc8inx 3521 12 transfusing transfuse VBG cord-010092-uftc8inx 3521 13 ( ( -LRB- cord-010092-uftc8inx 3521 14 leukoreduced leukoreduced JJ cord-010092-uftc8inx 3521 15 ) ) -RRB- cord-010092-uftc8inx 3521 16 PI PI NNP cord-010092-uftc8inx 3521 17 PLT PLT NNP cord-010092-uftc8inx 3521 18 as as IN cord-010092-uftc8inx 3521 19 compare compare VBP cord-010092-uftc8inx 3521 20 to to IN cord-010092-uftc8inx 3521 21 conventional conventional JJ cord-010092-uftc8inx 3521 22 PLT PLT NNP cord-010092-uftc8inx 3521 23 . . . cord-010092-uftc8inx 3522 1 In in IN cord-010092-uftc8inx 3522 2 the the DT cord-010092-uftc8inx 3522 3 clinical clinical JJ cord-010092-uftc8inx 3522 4 setting setting NN cord-010092-uftc8inx 3522 5 , , , cord-010092-uftc8inx 3522 6 published publish VBN cord-010092-uftc8inx 3522 7 data datum NNS cord-010092-uftc8inx 3522 8 , , , cord-010092-uftc8inx 3522 9 including include VBG cord-010092-uftc8inx 3522 10 very very RB cord-010092-uftc8inx 3522 11 recent recent JJ cord-010092-uftc8inx 3522 12 reports report NNS cord-010092-uftc8inx 3522 13 , , , cord-010092-uftc8inx 3522 14 showed show VBD cord-010092-uftc8inx 3522 15 different different JJ cord-010092-uftc8inx 3522 16 rates rate NNS cord-010092-uftc8inx 3522 17 of of IN cord-010092-uftc8inx 3522 18 HLA HLA NNP cord-010092-uftc8inx 3522 19 class class NN cord-010092-uftc8inx 3522 20 I i NN cord-010092-uftc8inx 3522 21 and and CC cord-010092-uftc8inx 3522 22 II II NNP cord-010092-uftc8inx 3522 23 alloimmunization alloimmunization NN cord-010092-uftc8inx 3522 24 with with IN cord-010092-uftc8inx 3522 25 the the DT cord-010092-uftc8inx 3522 26 two two CD cord-010092-uftc8inx 3522 27 currently currently RB cord-010092-uftc8inx 3522 28 available available JJ cord-010092-uftc8inx 3522 29 photochemical photochemical JJ cord-010092-uftc8inx 3522 30 based base VBN cord-010092-uftc8inx 3522 31 PI PI NNP cord-010092-uftc8inx 3522 32 technologies technology NNS cord-010092-uftc8inx 3522 33 . . . cord-010092-uftc8inx 3523 1 While while IN cord-010092-uftc8inx 3523 2 PI PI NNP cord-010092-uftc8inx 3523 3 of of IN cord-010092-uftc8inx 3523 4 PLT PLT NNP cord-010092-uftc8inx 3523 5 components component NNS cord-010092-uftc8inx 3523 6 surely surely RB cord-010092-uftc8inx 3523 7 benefit benefit VBP cord-010092-uftc8inx 3523 8 patients patient NNS cord-010092-uftc8inx 3523 9 regarding regard VBG cord-010092-uftc8inx 3523 10 pathogen pathogen NN cord-010092-uftc8inx 3523 11 safety safety NN cord-010092-uftc8inx 3523 12 , , , cord-010092-uftc8inx 3523 13 the the DT cord-010092-uftc8inx 3523 14 impact impact NN cord-010092-uftc8inx 3523 15 of of IN cord-010092-uftc8inx 3523 16 potential potential JJ cord-010092-uftc8inx 3523 17 off off RP cord-010092-uftc8inx 3523 18 target target NN cord-010092-uftc8inx 3523 19 effects effect NNS cord-010092-uftc8inx 3523 20 possibly possibly RB cord-010092-uftc8inx 3523 21 impairing impair VBG cord-010092-uftc8inx 3523 22 efficacy efficacy NN cord-010092-uftc8inx 3523 23 of of IN cord-010092-uftc8inx 3523 24 PI PI NNP cord-010092-uftc8inx 3523 25 PLT PLT NNP cord-010092-uftc8inx 3523 26 transfusions transfusion NNS cord-010092-uftc8inx 3523 27 need need VBP cord-010092-uftc8inx 3523 28 more more JJR cord-010092-uftc8inx 3523 29 investigation investigation NN cord-010092-uftc8inx 3523 30 . . . cord-010092-uftc8inx 3524 1 Background background NN cord-010092-uftc8inx 3524 2 : : : cord-010092-uftc8inx 3525 1 Brucellosis brucellosis NN cord-010092-uftc8inx 3525 2 is be VBZ cord-010092-uftc8inx 3525 3 an an DT cord-010092-uftc8inx 3525 4 endemic endemic JJ cord-010092-uftc8inx 3525 5 disease disease NN cord-010092-uftc8inx 3525 6 and and CC cord-010092-uftc8inx 3525 7 still still RB cord-010092-uftc8inx 3525 8 a a DT cord-010092-uftc8inx 3525 9 major major JJ cord-010092-uftc8inx 3525 10 health health NN cord-010092-uftc8inx 3525 11 problem problem NN cord-010092-uftc8inx 3525 12 in in IN cord-010092-uftc8inx 3525 13 Saudi Saudi NNP cord-010092-uftc8inx 3525 14 Arabia Arabia NNP cord-010092-uftc8inx 3525 15 . . . cord-010092-uftc8inx 3526 1 Ministry Ministry NNP cord-010092-uftc8inx 3526 2 of of IN cord-010092-uftc8inx 3526 3 Health Health NNP cord-010092-uftc8inx 3526 4 in in IN cord-010092-uftc8inx 3526 5 Saudi Saudi NNP cord-010092-uftc8inx 3526 6 Arabia Arabia NNP cord-010092-uftc8inx 3526 7 listed list VBD cord-010092-uftc8inx 3526 8 Brucellosis Brucellosis NNP cord-010092-uftc8inx 3526 9 as as IN cord-010092-uftc8inx 3526 10 a a DT cord-010092-uftc8inx 3526 11 notifiable notifiable JJ cord-010092-uftc8inx 3526 12 disease disease NN cord-010092-uftc8inx 3526 13 due due IN cord-010092-uftc8inx 3526 14 to to IN cord-010092-uftc8inx 3526 15 its -PRON- PRP$ cord-010092-uftc8inx 3526 16 endemicity endemicity NN cord-010092-uftc8inx 3526 17 . . . cord-010092-uftc8inx 3527 1 In in IN cord-010092-uftc8inx 3527 2 the the DT cord-010092-uftc8inx 3527 3 last last JJ cord-010092-uftc8inx 3527 4 ten ten CD cord-010092-uftc8inx 3527 5 years year NNS cord-010092-uftc8inx 3527 6 , , , cord-010092-uftc8inx 3527 7 the the DT cord-010092-uftc8inx 3527 8 incidence incidence NN cord-010092-uftc8inx 3527 9 has have VBZ cord-010092-uftc8inx 3527 10 decreased decrease VBN cord-010092-uftc8inx 3527 11 significantly significantly RB cord-010092-uftc8inx 3527 12 to to IN cord-010092-uftc8inx 3527 13 approximately approximately RB cord-010092-uftc8inx 3527 14 15 15 CD cord-010092-uftc8inx 3527 15 cases case NNS cord-010092-uftc8inx 3527 16 per per IN cord-010092-uftc8inx 3527 17 100,000 100,000 CD cord-010092-uftc8inx 3527 18 but but CC cord-010092-uftc8inx 3527 19 is be VBZ cord-010092-uftc8inx 3527 20 still still RB cord-010092-uftc8inx 3527 21 higher high JJR cord-010092-uftc8inx 3527 22 than than IN cord-010092-uftc8inx 3527 23 that that DT cord-010092-uftc8inx 3527 24 in in IN cord-010092-uftc8inx 3527 25 developed develop VBN cord-010092-uftc8inx 3527 26 countries country NNS cord-010092-uftc8inx 3527 27 . . . cord-010092-uftc8inx 3528 1 Human human NN cord-010092-uftc8inx 3528 2 - - HYPH cord-010092-uftc8inx 3528 3 to to IN cord-010092-uftc8inx 3528 4 human human JJ cord-010092-uftc8inx 3528 5 transmission transmission NN cord-010092-uftc8inx 3528 6 is be VBZ cord-010092-uftc8inx 3528 7 extremely extremely RB cord-010092-uftc8inx 3528 8 rare rare JJ cord-010092-uftc8inx 3528 9 including include VBG cord-010092-uftc8inx 3528 10 breast breast NN cord-010092-uftc8inx 3528 11 feeding feeding NN cord-010092-uftc8inx 3528 12 , , , cord-010092-uftc8inx 3528 13 transplacental transplacental NNP cord-010092-uftc8inx 3528 14 , , , cord-010092-uftc8inx 3528 15 sexually sexually RB cord-010092-uftc8inx 3528 16 and and CC cord-010092-uftc8inx 3528 17 blood blood NN cord-010092-uftc8inx 3528 18 transfusion transfusion NN cord-010092-uftc8inx 3528 19 . . . cord-010092-uftc8inx 3529 1 Five five CD cord-010092-uftc8inx 3529 2 cases case NNS cord-010092-uftc8inx 3529 3 of of IN cord-010092-uftc8inx 3529 4 Brucellosis brucellosis NN cord-010092-uftc8inx 3529 5 through through IN cord-010092-uftc8inx 3529 6 blood blood NN cord-010092-uftc8inx 3529 7 transfusion transfusion NN cord-010092-uftc8inx 3529 8 have have VBP cord-010092-uftc8inx 3529 9 been be VBN cord-010092-uftc8inx 3529 10 reported report VBN cord-010092-uftc8inx 3529 11 in in IN cord-010092-uftc8inx 3529 12 the the DT cord-010092-uftc8inx 3529 13 literature literature NN cord-010092-uftc8inx 3529 14 . . . cord-010092-uftc8inx 3530 1 Brucella Brucella NNP cord-010092-uftc8inx 3530 2 transmission transmission NN cord-010092-uftc8inx 3530 3 through through IN cord-010092-uftc8inx 3530 4 blood blood NN cord-010092-uftc8inx 3530 5 transfusion transfusion NN cord-010092-uftc8inx 3530 6 is be VBZ cord-010092-uftc8inx 3530 7 likely likely RB cord-010092-uftc8inx 3530 8 underreporting underreporte VBG cord-010092-uftc8inx 3530 9 due due IN cord-010092-uftc8inx 3530 10 to to IN cord-010092-uftc8inx 3530 11 the the DT cord-010092-uftc8inx 3530 12 long long JJ cord-010092-uftc8inx 3530 13 incubation incubation NN cord-010092-uftc8inx 3530 14 time time NN cord-010092-uftc8inx 3530 15 of of IN cord-010092-uftc8inx 3530 16 2 2 CD cord-010092-uftc8inx 3530 17 - - SYM cord-010092-uftc8inx 3530 18 4 4 CD cord-010092-uftc8inx 3530 19 weeks week NNS cord-010092-uftc8inx 3530 20 ( ( -LRB- cord-010092-uftc8inx 3530 21 range range NN cord-010092-uftc8inx 3530 22 , , , cord-010092-uftc8inx 3530 23 5 5 CD cord-010092-uftc8inx 3530 24 days day NNS cord-010092-uftc8inx 3530 25 to to IN cord-010092-uftc8inx 3530 26 5 5 CD cord-010092-uftc8inx 3530 27 months),vagueness months),vagueness NN cord-010092-uftc8inx 3530 28 of of IN cord-010092-uftc8inx 3530 29 clinical clinical JJ cord-010092-uftc8inx 3530 30 presentation presentation NN cord-010092-uftc8inx 3530 31 and and CC cord-010092-uftc8inx 3530 32 lack lack NN cord-010092-uftc8inx 3530 33 of of IN cord-010092-uftc8inx 3530 34 hemovigilance hemovigilance NN cord-010092-uftc8inx 3530 35 systems system NNS cord-010092-uftc8inx 3530 36 in in IN cord-010092-uftc8inx 3530 37 endemic endemic JJ cord-010092-uftc8inx 3530 38 areas area NNS cord-010092-uftc8inx 3530 39 . . . cord-010092-uftc8inx 3531 1 ( ( -LRB- cord-010092-uftc8inx 3531 2 alloHSCT alloHSCT NNP cord-010092-uftc8inx 3531 3 ) ) -RRB- cord-010092-uftc8inx 3531 4 and and CC cord-010092-uftc8inx 3531 5 130 130 CD cord-010092-uftc8inx 3531 6 ( ( -LRB- cord-010092-uftc8inx 3531 7 4.6 4.6 CD cord-010092-uftc8inx 3531 8 % % NN cord-010092-uftc8inx 3531 9 ) ) -RRB- cord-010092-uftc8inx 3531 10 autologous autologous JJ cord-010092-uftc8inx 3531 11 ( ( -LRB- cord-010092-uftc8inx 3531 12 autoHSCT autoHSCT NNP cord-010092-uftc8inx 3531 13 ) ) -RRB- cord-010092-uftc8inx 3531 14 HSCT HSCT NNP cord-010092-uftc8inx 3531 15 patients patient NNS cord-010092-uftc8inx 3531 16 , , , cord-010092-uftc8inx 3531 17 with with IN cord-010092-uftc8inx 3531 18 mean mean JJ cord-010092-uftc8inx 3531 19 corrected correct VBN cord-010092-uftc8inx 3531 20 count count NN cord-010092-uftc8inx 3531 21 increments increment NNS cord-010092-uftc8inx 3531 22 ( ( -LRB- cord-010092-uftc8inx 3531 23 CCI CCI NNP cord-010092-uftc8inx 3531 24 ) ) -RRB- cord-010092-uftc8inx 3531 25 of of IN cord-010092-uftc8inx 3531 26 8.7 8.7 CD cord-010092-uftc8inx 3531 27 9 9 CD cord-010092-uftc8inx 3531 28 10 10 CD cord-010092-uftc8inx 3531 29 3 3 CD cord-010092-uftc8inx 3531 30 , , , cord-010092-uftc8inx 3531 31 8.0 8.0 CD cord-010092-uftc8inx 3531 32 9 9 CD cord-010092-uftc8inx 3531 33 10 10 CD cord-010092-uftc8inx 3531 34 3 3 CD cord-010092-uftc8inx 3531 35 and and CC cord-010092-uftc8inx 3531 36 7.2 7.2 CD cord-010092-uftc8inx 3531 37 9 9 CD cord-010092-uftc8inx 3531 38 10 10 CD cord-010092-uftc8inx 3531 39 3 3 CD cord-010092-uftc8inx 3531 40 , , , cord-010092-uftc8inx 3531 41 respectively respectively RB cord-010092-uftc8inx 3531 42 . . . cord-010092-uftc8inx 3532 1 Mean mean JJ cord-010092-uftc8inx 3532 2 CCI CCI NNP cord-010092-uftc8inx 3532 3 decreased decrease VBD cord-010092-uftc8inx 3532 4 in in IN cord-010092-uftc8inx 3532 5 a a DT cord-010092-uftc8inx 3532 6 linear linear JJ cord-010092-uftc8inx 3532 7 fashion fashion NN cord-010092-uftc8inx 3532 8 between between IN cord-010092-uftc8inx 3532 9 Day Day NNP cord-010092-uftc8inx 3532 10 ≤ ≤ NNP cord-010092-uftc8inx 3532 11 2 2 CD cord-010092-uftc8inx 3532 12 and and CC cord-010092-uftc8inx 3532 13 Day Day NNP cord-010092-uftc8inx 3532 14 7 7 CD cord-010092-uftc8inx 3532 15 PCs pc NNS cord-010092-uftc8inx 3532 16 ( ( -LRB- cord-010092-uftc8inx 3532 17 9.0 9.0 CD cord-010092-uftc8inx 3532 18 9 9 CD cord-010092-uftc8inx 3532 19 10 10 CD cord-010092-uftc8inx 3532 20 3 3 CD cord-010092-uftc8inx 3532 21 , , , cord-010092-uftc8inx 3532 22 9.1 9.1 CD cord-010092-uftc8inx 3532 23 9 9 CD cord-010092-uftc8inx 3532 24 10 10 CD cord-010092-uftc8inx 3532 25 3 3 CD cord-010092-uftc8inx 3532 26 and and CC cord-010092-uftc8inx 3532 27 8.5 8.5 CD cord-010092-uftc8inx 3532 28 9 9 CD cord-010092-uftc8inx 3532 29 10 10 CD cord-010092-uftc8inx 3532 30 3 3 CD cord-010092-uftc8inx 3532 31 at at IN cord-010092-uftc8inx 3532 32 ≤ ≤ NN cord-010092-uftc8inx 3532 33 2 2 CD cord-010092-uftc8inx 3532 34 days day NNS cord-010092-uftc8inx 3532 35 ; ; : cord-010092-uftc8inx 3532 36 6.7 6.7 CD cord-010092-uftc8inx 3532 37 9 9 CD cord-010092-uftc8inx 3532 38 10 10 CD cord-010092-uftc8inx 3532 39 3 3 CD cord-010092-uftc8inx 3532 40 , , , cord-010092-uftc8inx 3532 41 5.8 5.8 CD cord-010092-uftc8inx 3532 42 9 9 CD cord-010092-uftc8inx 3532 43 10 10 CD cord-010092-uftc8inx 3532 44 3 3 CD cord-010092-uftc8inx 3532 45 and and CC cord-010092-uftc8inx 3532 46 4.9 4.9 CD cord-010092-uftc8inx 3532 47 9 9 CD cord-010092-uftc8inx 3532 48 10 10 CD cord-010092-uftc8inx 3532 49 3 3 CD cord-010092-uftc8inx 3532 50 at at IN cord-010092-uftc8inx 3532 51 7 7 CD cord-010092-uftc8inx 3532 52 days day NNS cord-010092-uftc8inx 3532 53 , , , cord-010092-uftc8inx 3532 54 respectively respectively RB cord-010092-uftc8inx 3532 55 ) ) -RRB- cord-010092-uftc8inx 3532 56 , , , cord-010092-uftc8inx 3532 57 although although IN cord-010092-uftc8inx 3532 58 the the DT cord-010092-uftc8inx 3532 59 number number NN cord-010092-uftc8inx 3532 60 of of IN cord-010092-uftc8inx 3532 61 PC pc NN cord-010092-uftc8inx 3532 62 transfused transfuse VBN cord-010092-uftc8inx 3532 63 on on IN cord-010092-uftc8inx 3532 64 Day Day NNP cord-010092-uftc8inx 3532 65 7 7 CD cord-010092-uftc8inx 3532 66 to to IN cord-010092-uftc8inx 3532 67 autoHSCT autoHSCT NNP cord-010092-uftc8inx 3532 68 patients patient NNS cord-010092-uftc8inx 3532 69 was be VBD cord-010092-uftc8inx 3532 70 small small JJ cord-010092-uftc8inx 3532 71 ( ( -LRB- cord-010092-uftc8inx 3532 72 n n NN cord-010092-uftc8inx 3532 73 = = SYM cord-010092-uftc8inx 3532 74 71 71 CD cord-010092-uftc8inx 3532 75 ) ) -RRB- cord-010092-uftc8inx 3532 76 . . . cord-010092-uftc8inx 3533 1 Background background NN cord-010092-uftc8inx 3533 2 : : : cord-010092-uftc8inx 3534 1 Nipah Nipah NNP cord-010092-uftc8inx 3534 2 virus virus NN cord-010092-uftc8inx 3534 3 ( ( -LRB- cord-010092-uftc8inx 3534 4 NiV NiV NNP cord-010092-uftc8inx 3534 5 ) ) -RRB- cord-010092-uftc8inx 3534 6 is be VBZ cord-010092-uftc8inx 3534 7 a a DT cord-010092-uftc8inx 3534 8 paramyxovirus paramyxovirus JJ cord-010092-uftc8inx 3534 9 ( ( -LRB- cord-010092-uftc8inx 3534 10 genus genus NN cord-010092-uftc8inx 3534 11 Henipavirus Henipavirus NNP cord-010092-uftc8inx 3534 12 ) ) -RRB- cord-010092-uftc8inx 3534 13 that that WDT cord-010092-uftc8inx 3534 14 emerged emerge VBD cord-010092-uftc8inx 3534 15 in in IN cord-010092-uftc8inx 3534 16 the the DT cord-010092-uftc8inx 3534 17 late late JJ cord-010092-uftc8inx 3534 18 1990s 1990 NNS cord-010092-uftc8inx 3534 19 in in IN cord-010092-uftc8inx 3534 20 Malaysia Malaysia NNP cord-010092-uftc8inx 3534 21 and and CC cord-010092-uftc8inx 3534 22 has have VBZ cord-010092-uftc8inx 3534 23 since since IN cord-010092-uftc8inx 3534 24 been be VBN cord-010092-uftc8inx 3534 25 identified identify VBN cord-010092-uftc8inx 3534 26 as as IN cord-010092-uftc8inx 3534 27 the the DT cord-010092-uftc8inx 3534 28 cause cause NN cord-010092-uftc8inx 3534 29 of of IN cord-010092-uftc8inx 3534 30 sporadic sporadic JJ cord-010092-uftc8inx 3534 31 outbreaks outbreak NNS cord-010092-uftc8inx 3534 32 of of IN cord-010092-uftc8inx 3534 33 severe severe JJ cord-010092-uftc8inx 3534 34 febrile febrile JJ cord-010092-uftc8inx 3534 35 disease disease NN cord-010092-uftc8inx 3534 36 in in IN cord-010092-uftc8inx 3534 37 Bangladesh Bangladesh NNP cord-010092-uftc8inx 3534 38 and and CC cord-010092-uftc8inx 3534 39 India India NNP cord-010092-uftc8inx 3534 40 . . . cord-010092-uftc8inx 3535 1 NiV NiV NNP cord-010092-uftc8inx 3535 2 infection infection NN cord-010092-uftc8inx 3535 3 is be VBZ cord-010092-uftc8inx 3535 4 frequently frequently RB cord-010092-uftc8inx 3535 5 associated associate VBN cord-010092-uftc8inx 3535 6 with with IN cord-010092-uftc8inx 3535 7 severe severe JJ cord-010092-uftc8inx 3535 8 respiratory respiratory JJ cord-010092-uftc8inx 3535 9 or or CC cord-010092-uftc8inx 3535 10 neurological neurological JJ cord-010092-uftc8inx 3535 11 disease disease NN cord-010092-uftc8inx 3535 12 in in IN cord-010092-uftc8inx 3535 13 infected infected JJ cord-010092-uftc8inx 3535 14 humans human NNS cord-010092-uftc8inx 3535 15 with with IN cord-010092-uftc8inx 3535 16 transmission transmission NN cord-010092-uftc8inx 3535 17 to to IN cord-010092-uftc8inx 3535 18 humans human NNS cord-010092-uftc8inx 3535 19 through through IN cord-010092-uftc8inx 3535 20 inhalation inhalation NN cord-010092-uftc8inx 3535 21 , , , cord-010092-uftc8inx 3535 22 contact contact NN cord-010092-uftc8inx 3535 23 or or CC cord-010092-uftc8inx 3535 24 consumption consumption NN cord-010092-uftc8inx 3535 25 of of IN cord-010092-uftc8inx 3535 26 NiV niv NN cord-010092-uftc8inx 3535 27 contaminated contaminate VBN cord-010092-uftc8inx 3535 28 foods food NNS cord-010092-uftc8inx 3535 29 . . . cord-010092-uftc8inx 3536 1 Nipah Nipah NNP cord-010092-uftc8inx 3536 2 virus virus NN cord-010092-uftc8inx 3536 3 ( ( -LRB- cord-010092-uftc8inx 3536 4 NiV NiV NNP cord-010092-uftc8inx 3536 5 ) ) -RRB- cord-010092-uftc8inx 3536 6 belongs belong VBZ cord-010092-uftc8inx 3536 7 to to IN cord-010092-uftc8inx 3536 8 the the DT cord-010092-uftc8inx 3536 9 list list NN cord-010092-uftc8inx 3536 10 of of IN cord-010092-uftc8inx 3536 11 pathogens pathogen NNS cord-010092-uftc8inx 3536 12 identified identify VBN cord-010092-uftc8inx 3536 13 by by IN cord-010092-uftc8inx 3536 14 the the DT cord-010092-uftc8inx 3536 15 WHO WHO NNP cord-010092-uftc8inx 3536 16 to to TO cord-010092-uftc8inx 3536 17 have have VB cord-010092-uftc8inx 3536 18 the the DT cord-010092-uftc8inx 3536 19 potential potential NN cord-010092-uftc8inx 3536 20 for for IN cord-010092-uftc8inx 3536 21 a a DT cord-010092-uftc8inx 3536 22 global global JJ cord-010092-uftc8inx 3536 23 pandemic pandemic NN cord-010092-uftc8inx 3536 24 . . . cord-010092-uftc8inx 3537 1 Aims aim VBZ cord-010092-uftc8inx 3537 2 : : : cord-010092-uftc8inx 3538 1 This this DT cord-010092-uftc8inx 3538 2 study study NN cord-010092-uftc8inx 3538 3 aimed aim VBD cord-010092-uftc8inx 3538 4 to to TO cord-010092-uftc8inx 3538 5 investigate investigate VB cord-010092-uftc8inx 3538 6 the the DT cord-010092-uftc8inx 3538 7 efficacy efficacy NN cord-010092-uftc8inx 3538 8 of of IN cord-010092-uftc8inx 3538 9 the the DT cord-010092-uftc8inx 3538 10 THERAFLEX THERAFLEX NNP cord-010092-uftc8inx 3538 11 UV uv NN cord-010092-uftc8inx 3538 12 - - HYPH cord-010092-uftc8inx 3538 13 Platelets platelet NNS cord-010092-uftc8inx 3538 14 system system NN cord-010092-uftc8inx 3538 15 to to TO cord-010092-uftc8inx 3538 16 inactivate inactivate VB cord-010092-uftc8inx 3538 17 NiV niv NN cord-010092-uftc8inx 3538 18 in in IN cord-010092-uftc8inx 3538 19 platelet platelet NN cord-010092-uftc8inx 3538 20 concentrates concentrate NNS cord-010092-uftc8inx 3538 21 ( ( -LRB- cord-010092-uftc8inx 3538 22 PCs pc NNS cord-010092-uftc8inx 3538 23 ) ) -RRB- cord-010092-uftc8inx 3538 24 . . . cord-010092-uftc8inx 3539 1 The the DT cord-010092-uftc8inx 3539 2 THERAFLEX THERAFLEX NNP cord-010092-uftc8inx 3539 3 UV uv NN cord-010092-uftc8inx 3539 4 - - HYPH cord-010092-uftc8inx 3539 5 Platelets platelet NNS cord-010092-uftc8inx 3539 6 system system NN cord-010092-uftc8inx 3539 7 ( ( -LRB- cord-010092-uftc8inx 3539 8 Macopharma Macopharma NNP cord-010092-uftc8inx 3539 9 ) ) -RRB- cord-010092-uftc8inx 3539 10 uses use VBZ cord-010092-uftc8inx 3539 11 UVC uvc NN cord-010092-uftc8inx 3539 12 light light NN cord-010092-uftc8inx 3539 13 without without IN cord-010092-uftc8inx 3539 14 the the DT cord-010092-uftc8inx 3539 15 need need NN cord-010092-uftc8inx 3539 16 of of IN cord-010092-uftc8inx 3539 17 any any DT cord-010092-uftc8inx 3539 18 additional additional JJ cord-010092-uftc8inx 3539 19 photoactive photoactive JJ cord-010092-uftc8inx 3539 20 compound compound NN cord-010092-uftc8inx 3539 21 . . . cord-010092-uftc8inx 3540 1 Methods method NNS cord-010092-uftc8inx 3540 2 : : : cord-010092-uftc8inx 3541 1 Plasma plasma NN cord-010092-uftc8inx 3541 2 reduced reduce VBD cord-010092-uftc8inx 3541 3 PCs pc NNS cord-010092-uftc8inx 3541 4 from from IN cord-010092-uftc8inx 3541 5 4 4 CD cord-010092-uftc8inx 3541 6 BCs bc NNS cord-010092-uftc8inx 3541 7 ( ( -LRB- cord-010092-uftc8inx 3541 8 35 35 CD cord-010092-uftc8inx 3541 9 % % NN cord-010092-uftc8inx 3541 10 plasma plasma NN cord-010092-uftc8inx 3541 11 in in IN cord-010092-uftc8inx 3541 12 additive additive NN cord-010092-uftc8inx 3541 13 solution solution NN cord-010092-uftc8inx 3541 14 SSP+ SSP+ NNP cord-010092-uftc8inx 3541 15 ) ) -RRB- cord-010092-uftc8inx 3541 16 were be VBD cord-010092-uftc8inx 3541 17 spiked spike VBN cord-010092-uftc8inx 3541 18 with with IN cord-010092-uftc8inx 3541 19 virus virus NN cord-010092-uftc8inx 3541 20 suspension suspension NN cord-010092-uftc8inx 3541 21 ( ( -LRB- cord-010092-uftc8inx 3541 22 10 10 CD cord-010092-uftc8inx 3541 23 % % NN cord-010092-uftc8inx 3541 24 v v NN cord-010092-uftc8inx 3541 25 / / SYM cord-010092-uftc8inx 3541 26 v v NN cord-010092-uftc8inx 3541 27 ) ) -RRB- cord-010092-uftc8inx 3541 28 . . . cord-010092-uftc8inx 3542 1 PCs pc NNS cord-010092-uftc8inx 3542 2 ( ( -LRB- cord-010092-uftc8inx 3542 3 n n NN cord-010092-uftc8inx 3542 4 = = SYM cord-010092-uftc8inx 3542 5 2 2 CD cord-010092-uftc8inx 3542 6 , , , cord-010092-uftc8inx 3542 7 375 375 CD cord-010092-uftc8inx 3542 8 mL ml NN cord-010092-uftc8inx 3542 9 ) ) -RRB- cord-010092-uftc8inx 3542 10 were be VBD cord-010092-uftc8inx 3542 11 then then RB cord-010092-uftc8inx 3542 12 UVCirradiated uvcirradiate VBN cord-010092-uftc8inx 3542 13 on on IN cord-010092-uftc8inx 3542 14 the the DT cord-010092-uftc8inx 3542 15 Macotronic Macotronic NNP cord-010092-uftc8inx 3542 16 UV uv NN cord-010092-uftc8inx 3542 17 machine machine NN cord-010092-uftc8inx 3542 18 ( ( -LRB- cord-010092-uftc8inx 3542 19 Macopharma Macopharma NNP cord-010092-uftc8inx 3542 20 ) ) -RRB- cord-010092-uftc8inx 3542 21 and and CC cord-010092-uftc8inx 3542 22 samples sample NNS cord-010092-uftc8inx 3542 23 were be VBD cord-010092-uftc8inx 3542 24 taken take VBN cord-010092-uftc8inx 3542 25 after after IN cord-010092-uftc8inx 3542 26 spiking spike VBG cord-010092-uftc8inx 3542 27 ( ( -LRB- cord-010092-uftc8inx 3542 28 load load NN cord-010092-uftc8inx 3542 29 and and CC cord-010092-uftc8inx 3542 30 hold hold VB cord-010092-uftc8inx 3542 31 sample sample NN cord-010092-uftc8inx 3542 32 ) ) -RRB- cord-010092-uftc8inx 3542 33 and and CC cord-010092-uftc8inx 3542 34 after after IN cord-010092-uftc8inx 3542 35 illumination illumination NN cord-010092-uftc8inx 3542 36 with with IN cord-010092-uftc8inx 3542 37 different different JJ cord-010092-uftc8inx 3542 38 light light JJ cord-010092-uftc8inx 3542 39 doses dose NNS cord-010092-uftc8inx 3542 40 ( ( -LRB- cord-010092-uftc8inx 3542 41 0.05 0.05 CD cord-010092-uftc8inx 3542 42 , , , cord-010092-uftc8inx 3542 43 0.1 0.1 CD cord-010092-uftc8inx 3542 44 , , , cord-010092-uftc8inx 3542 45 0.15 0.15 CD cord-010092-uftc8inx 3542 46 and and CC cord-010092-uftc8inx 3542 47 0.2 0.2 CD cord-010092-uftc8inx 3542 48 ( ( -LRB- cord-010092-uftc8inx 3542 49 standard standard NN cord-010092-uftc8inx 3542 50 ) ) -RRB- cord-010092-uftc8inx 3542 51 J J NNP cord-010092-uftc8inx 3542 52 / / SYM cord-010092-uftc8inx 3542 53 cm cm NNP cord-010092-uftc8inx 3542 54 2 2 CD cord-010092-uftc8inx 3542 55 ) ) -RRB- cord-010092-uftc8inx 3542 56 ) ) -RRB- cord-010092-uftc8inx 3542 57 . . . cord-010092-uftc8inx 3543 1 The the DT cord-010092-uftc8inx 3543 2 titre titre NN cord-010092-uftc8inx 3543 3 of of IN cord-010092-uftc8inx 3543 4 the the DT cord-010092-uftc8inx 3543 5 NiV niv NN cord-010092-uftc8inx 3543 6 ( ( -LRB- cord-010092-uftc8inx 3543 7 Malaysia Malaysia NNP cord-010092-uftc8inx 3543 8 ) ) -RRB- cord-010092-uftc8inx 3543 9 was be VBD cord-010092-uftc8inx 3543 10 determined determine VBN cord-010092-uftc8inx 3543 11 as as IN cord-010092-uftc8inx 3543 12 tissue tissue NN cord-010092-uftc8inx 3543 13 culture culture NN cord-010092-uftc8inx 3543 14 infective infective JJ cord-010092-uftc8inx 3543 15 dose dose NN cord-010092-uftc8inx 3543 16 ( ( -LRB- cord-010092-uftc8inx 3543 17 TCID TCID NNP cord-010092-uftc8inx 3543 18 50 50 CD cord-010092-uftc8inx 3543 19 ) ) -RRB- cord-010092-uftc8inx 3543 20 by by IN cord-010092-uftc8inx 3543 21 endpoint endpoint NN cord-010092-uftc8inx 3543 22 titration titration NN cord-010092-uftc8inx 3543 23 in in IN cord-010092-uftc8inx 3543 24 microtitre microtitre NNP cord-010092-uftc8inx 3543 25 plate plate NN cord-010092-uftc8inx 3543 26 assays assay NNS cord-010092-uftc8inx 3543 27 on on IN cord-010092-uftc8inx 3543 28 Vero Vero NNP cord-010092-uftc8inx 3543 29 76 76 CD cord-010092-uftc8inx 3543 30 cells cell NNS cord-010092-uftc8inx 3543 31 ( ( -LRB- cord-010092-uftc8inx 3543 32 ATCC ATCC NNP cord-010092-uftc8inx 3543 33 â â LS cord-010092-uftc8inx 3543 34 CRL-1587 CRL-1587 NNP cord-010092-uftc8inx 3543 35 TM TM NNP cord-010092-uftc8inx 3543 36 ) ) -RRB- cord-010092-uftc8inx 3543 37 . . . cord-010092-uftc8inx 3544 1 The the DT cord-010092-uftc8inx 3544 2 results result NNS cord-010092-uftc8inx 3544 3 of of IN cord-010092-uftc8inx 3544 4 the the DT cord-010092-uftc8inx 3544 5 infectivity infectivity NN cord-010092-uftc8inx 3544 6 assay assay NN cord-010092-uftc8inx 3544 7 demonstrated demonstrate VBD cord-010092-uftc8inx 3544 8 that that IN cord-010092-uftc8inx 3544 9 UVC UVC NNP cord-010092-uftc8inx 3544 10 irradiation irradiation NN cord-010092-uftc8inx 3544 11 dosedependently dosedependently RB cord-010092-uftc8inx 3544 12 inactivated inactivate VBD cord-010092-uftc8inx 3544 13 NiV. NiV. NNP cord-010092-uftc8inx 3544 14 After after IN cord-010092-uftc8inx 3544 15 spiking spike VBG cord-010092-uftc8inx 3544 16 a a DT cord-010092-uftc8inx 3544 17 NiV niv NN cord-010092-uftc8inx 3544 18 titer titer NN cord-010092-uftc8inx 3544 19 of of IN cord-010092-uftc8inx 3544 20 6.2 6.2 CD cord-010092-uftc8inx 3544 21 ( ( -LRB- cord-010092-uftc8inx 3544 22 bag bag NN cord-010092-uftc8inx 3544 23 no no NN cord-010092-uftc8inx 3544 24 . . NN cord-010092-uftc8inx 3544 25 1 1 CD cord-010092-uftc8inx 3544 26 ) ) -RRB- cord-010092-uftc8inx 3544 27 and and CC cord-010092-uftc8inx 3544 28 6.5 6.5 CD cord-010092-uftc8inx 3544 29 ( ( -LRB- cord-010092-uftc8inx 3544 30 bag bag NN cord-010092-uftc8inx 3544 31 no no NN cord-010092-uftc8inx 3544 32 . . NN cord-010092-uftc8inx 3544 33 2 2 LS cord-010092-uftc8inx 3544 34 ) ) -RRB- cord-010092-uftc8inx 3544 35 log log VB cord-010092-uftc8inx 3544 36 10 10 CD cord-010092-uftc8inx 3544 37 TCID TCID NNP cord-010092-uftc8inx 3544 38 50 50 CD cord-010092-uftc8inx 3544 39 /mL /mL : cord-010092-uftc8inx 3544 40 was be VBD cord-010092-uftc8inx 3544 41 received receive VBN cord-010092-uftc8inx 3544 42 in in IN cord-010092-uftc8inx 3544 43 the the DT cord-010092-uftc8inx 3544 44 PCs pc NNS cord-010092-uftc8inx 3544 45 . . . cord-010092-uftc8inx 3545 1 At at IN cord-010092-uftc8inx 3545 2 a a DT cord-010092-uftc8inx 3545 3 UVC UVC NNP cord-010092-uftc8inx 3545 4 dose dose NN cord-010092-uftc8inx 3545 5 of of IN cord-010092-uftc8inx 3545 6 0.10 0.10 CD cord-010092-uftc8inx 3545 7 J J NNP cord-010092-uftc8inx 3545 8 / / SYM cord-010092-uftc8inx 3545 9 cm cm NNP cord-010092-uftc8inx 3545 10 2 2 CD cord-010092-uftc8inx 3545 11 and and CC cord-010092-uftc8inx 3545 12 higher high JJR cord-010092-uftc8inx 3545 13 NiV niv NN cord-010092-uftc8inx 3545 14 was be VBD cord-010092-uftc8inx 3545 15 inactivated inactivate VBN cord-010092-uftc8inx 3545 16 down down RP cord-010092-uftc8inx 3545 17 to to IN cord-010092-uftc8inx 3545 18 the the DT cord-010092-uftc8inx 3545 19 detection detection NN cord-010092-uftc8inx 3545 20 limit limit NN cord-010092-uftc8inx 3545 21 of of IN cord-010092-uftc8inx 3545 22 the the DT cord-010092-uftc8inx 3545 23 system system NN cord-010092-uftc8inx 3545 24 ( ( -LRB- cord-010092-uftc8inx 3545 25 1.9 1.9 CD cord-010092-uftc8inx 3545 26 log log NN cord-010092-uftc8inx 3545 27 10 10 CD cord-010092-uftc8inx 3545 28 TCID TCID NNP cord-010092-uftc8inx 3545 29 50 50 CD cord-010092-uftc8inx 3545 30 / / SYM cord-010092-uftc8inx 3545 31 mL ml NN cord-010092-uftc8inx 3545 32 ) ) -RRB- cord-010092-uftc8inx 3545 33 , , , cord-010092-uftc8inx 3545 34 resulting result VBG cord-010092-uftc8inx 3545 35 in in IN cord-010092-uftc8inx 3545 36 log log NN cord-010092-uftc8inx 3545 37 10 10 CD cord-010092-uftc8inx 3545 38 reduction reduction NN cord-010092-uftc8inx 3545 39 factors factor NNS cord-010092-uftc8inx 3545 40 of of IN cord-010092-uftc8inx 3545 41 ≥4.3 ≥4.3 NNPS cord-010092-uftc8inx 3545 42 ( ( -LRB- cord-010092-uftc8inx 3545 43 bag bag NN cord-010092-uftc8inx 3545 44 no no NN cord-010092-uftc8inx 3545 45 . . NN cord-010092-uftc8inx 3545 46 1 1 CD cord-010092-uftc8inx 3545 47 ) ) -RRB- cord-010092-uftc8inx 3545 48 and and CC cord-010092-uftc8inx 3545 49 ≥4.6 ≥4.6 NNP cord-010092-uftc8inx 3545 50 ( ( -LRB- cord-010092-uftc8inx 3545 51 bag bag VB cord-010092-uftc8inx 3545 52 no no NN cord-010092-uftc8inx 3545 53 . . NN cord-010092-uftc8inx 3545 54 2 2 CD cord-010092-uftc8inx 3545 55 ) ) -RRB- cord-010092-uftc8inx 3545 56 . . . cord-010092-uftc8inx 3546 1 Summary Summary NNP cord-010092-uftc8inx 3546 2 / / SYM cord-010092-uftc8inx 3546 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 3546 4 : : : cord-010092-uftc8inx 3547 1 Our -PRON- PRP$ cord-010092-uftc8inx 3547 2 results result NNS cord-010092-uftc8inx 3547 3 demonstrate demonstrate VBP cord-010092-uftc8inx 3547 4 that that IN cord-010092-uftc8inx 3547 5 the the DT cord-010092-uftc8inx 3547 6 THERAFLEX THERAFLEX NNP cord-010092-uftc8inx 3547 7 UV uv NN cord-010092-uftc8inx 3547 8 - - HYPH cord-010092-uftc8inx 3547 9 Platelets platelet NNS cord-010092-uftc8inx 3547 10 procedure procedure NN cord-010092-uftc8inx 3547 11 is be VBZ cord-010092-uftc8inx 3547 12 an an DT cord-010092-uftc8inx 3547 13 effective effective JJ cord-010092-uftc8inx 3547 14 technology technology NN cord-010092-uftc8inx 3547 15 to to TO cord-010092-uftc8inx 3547 16 inactivate inactivate VB cord-010092-uftc8inx 3547 17 NiV niv NN cord-010092-uftc8inx 3547 18 in in IN cord-010092-uftc8inx 3547 19 contaminated contaminated JJ cord-010092-uftc8inx 3547 20 PCs pc NNS cord-010092-uftc8inx 3547 21 . . . cord-010092-uftc8inx 3548 1 vs. vs. FW cord-010092-uftc8inx 3548 2 364 364 CD cord-010092-uftc8inx 3548 3 AE AE NNP cord-010092-uftc8inx 3548 4 20.6 20.6 CD cord-010092-uftc8inx 3548 5 9 9 CD cord-010092-uftc8inx 3548 6 10e11 10e11 CD cord-010092-uftc8inx 3548 7 platelets platelet NNS cord-010092-uftc8inx 3548 8 / / SYM cord-010092-uftc8inx 3548 9 unit unit NN cord-010092-uftc8inx 3548 10 , , , cord-010092-uftc8inx 3548 11 P p NN cord-010092-uftc8inx 3548 12 < < XX cord-010092-uftc8inx 3548 13 0.001 0.001 CD cord-010092-uftc8inx 3548 14 ) ) -RRB- cord-010092-uftc8inx 3548 15 , , , cord-010092-uftc8inx 3548 16 whereas whereas IN cord-010092-uftc8inx 3548 17 the the DT cord-010092-uftc8inx 3548 18 platelet platelet NN cord-010092-uftc8inx 3548 19 content content NN cord-010092-uftc8inx 3548 20 of of IN cord-010092-uftc8inx 3548 21 apheresis apheresis NN cord-010092-uftc8inx 3548 22 PC pc NN cord-010092-uftc8inx 3548 23 did do VBD cord-010092-uftc8inx 3548 24 not not RB cord-010092-uftc8inx 3548 25 change change VB cord-010092-uftc8inx 3548 26 ( ( -LRB- cord-010092-uftc8inx 3548 27 305 305 CD cord-010092-uftc8inx 3548 28 AE AE NNP cord-010092-uftc8inx 3548 29 9.9 9.9 CD cord-010092-uftc8inx 3548 30 vs. vs. IN cord-010092-uftc8inx 3548 31 300 300 CD cord-010092-uftc8inx 3548 32 , , , cord-010092-uftc8inx 3548 33 AE16.1 ae16.1 JJ cord-010092-uftc8inx 3548 34 , , , cord-010092-uftc8inx 3548 35 P p NN cord-010092-uftc8inx 3548 36 = = SYM cord-010092-uftc8inx 3548 37 0.57 0.57 CD cord-010092-uftc8inx 3548 38 ) ) -RRB- cord-010092-uftc8inx 3548 39 . . . cord-010092-uftc8inx 3549 1 Summary Summary NNP cord-010092-uftc8inx 3549 2 / / SYM cord-010092-uftc8inx 3549 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 3549 4 : : : cord-010092-uftc8inx 3550 1 Pathogen pathogen NN cord-010092-uftc8inx 3550 2 reduction reduction NN cord-010092-uftc8inx 3550 3 resulted result VBD cord-010092-uftc8inx 3550 4 in in IN cord-010092-uftc8inx 3550 5 the the DT cord-010092-uftc8inx 3550 6 transfusion transfusion NN cord-010092-uftc8inx 3550 7 of of IN cord-010092-uftc8inx 3550 8 older old JJR cord-010092-uftc8inx 3550 9 PC pc NN cord-010092-uftc8inx 3550 10 on on IN cord-010092-uftc8inx 3550 11 average average JJ cord-010092-uftc8inx 3550 12 , , , cord-010092-uftc8inx 3550 13 but but CC cord-010092-uftc8inx 3550 14 without without IN cord-010092-uftc8inx 3550 15 altering alter VBG cord-010092-uftc8inx 3550 16 the the DT cord-010092-uftc8inx 3550 17 number number NN cord-010092-uftc8inx 3550 18 of of IN cord-010092-uftc8inx 3550 19 PC pc NN cord-010092-uftc8inx 3550 20 ordered order VBN cord-010092-uftc8inx 3550 21 or or CC cord-010092-uftc8inx 3550 22 the the DT cord-010092-uftc8inx 3550 23 use use NN cord-010092-uftc8inx 3550 24 of of IN cord-010092-uftc8inx 3550 25 PC pc NN cord-010092-uftc8inx 3550 26 per per IN cord-010092-uftc8inx 3550 27 patient patient NN cord-010092-uftc8inx 3550 28 . . . cord-010092-uftc8inx 3551 1 Pathogen pathogen NN cord-010092-uftc8inx 3551 2 reduction reduction NN cord-010092-uftc8inx 3551 3 has have VBZ cord-010092-uftc8inx 3551 4 improved improve VBN cord-010092-uftc8inx 3551 5 PC pc NN cord-010092-uftc8inx 3551 6 stock stock NN cord-010092-uftc8inx 3551 7 management management NN cord-010092-uftc8inx 3551 8 without without IN cord-010092-uftc8inx 3551 9 an an DT cord-010092-uftc8inx 3551 10 increase increase NN cord-010092-uftc8inx 3551 11 in in IN cord-010092-uftc8inx 3551 12 platelet platelet NN cord-010092-uftc8inx 3551 13 demand demand NN cord-010092-uftc8inx 3551 14 , , , cord-010092-uftc8inx 3551 15 despite despite IN cord-010092-uftc8inx 3551 16 lower low JJR cord-010092-uftc8inx 3551 17 platelet platelet NN cord-010092-uftc8inx 3551 18 content content NN cord-010092-uftc8inx 3551 19 of of IN cord-010092-uftc8inx 3551 20 buffy buffy NNP cord-010092-uftc8inx 3551 21 coat coat NNP cord-010092-uftc8inx 3551 22 PC PC NNP cord-010092-uftc8inx 3551 23 after after IN cord-010092-uftc8inx 3551 24 PR PR NNP cord-010092-uftc8inx 3551 25 implementation implementation NN cord-010092-uftc8inx 3551 26 . . . cord-010092-uftc8inx 3552 1 Donors donor NNS cord-010092-uftc8inx 3552 2 and and CC cord-010092-uftc8inx 3552 3 Donation Donation NNP cord-010092-uftc8inx 3552 4 -Donor -Donor NNP cord-010092-uftc8inx 3552 5 Adherence adherence NN cord-010092-uftc8inx 3552 6 -are -are : cord-010092-uftc8inx 3552 7 we -PRON- PRP cord-010092-uftc8inx 3552 8 doing do VBG cord-010092-uftc8inx 3552 9 the the DT cord-010092-uftc8inx 3552 10 Right right JJ cord-010092-uftc8inx 3552 11 Thing thing NN cord-010092-uftc8inx 3552 12 ? ? . cord-010092-uftc8inx 3553 1 The the DT cord-010092-uftc8inx 3553 2 transfusion transfusion NN cord-010092-uftc8inx 3553 3 procedure procedure NN cord-010092-uftc8inx 3553 4 is be VBZ cord-010092-uftc8inx 3553 5 the the DT cord-010092-uftc8inx 3553 6 last last JJ cord-010092-uftc8inx 3553 7 step step NN cord-010092-uftc8inx 3553 8 in in IN cord-010092-uftc8inx 3553 9 a a DT cord-010092-uftc8inx 3553 10 multi multi JJ cord-010092-uftc8inx 3553 11 - - JJ cord-010092-uftc8inx 3553 12 process process JJ cord-010092-uftc8inx 3553 13 supply supply NN cord-010092-uftc8inx 3553 14 chain chain NN cord-010092-uftc8inx 3553 15 . . . cord-010092-uftc8inx 3554 1 The the DT cord-010092-uftc8inx 3554 2 task task NN cord-010092-uftc8inx 3554 3 of of IN cord-010092-uftc8inx 3554 4 matching match VBG cord-010092-uftc8inx 3554 5 supply supply NN cord-010092-uftc8inx 3554 6 with with IN cord-010092-uftc8inx 3554 7 demand demand NN cord-010092-uftc8inx 3554 8 requires require VBZ cord-010092-uftc8inx 3554 9 donor donor NN cord-010092-uftc8inx 3554 10 managers manager NNS cord-010092-uftc8inx 3554 11 to to TO cord-010092-uftc8inx 3554 12 consider consider VB cord-010092-uftc8inx 3554 13 average average JJ cord-010092-uftc8inx 3554 14 consumption consumption NN cord-010092-uftc8inx 3554 15 rates rate NNS cord-010092-uftc8inx 3554 16 on on IN cord-010092-uftc8inx 3554 17 a a DT cord-010092-uftc8inx 3554 18 weekly weekly JJ cord-010092-uftc8inx 3554 19 or or CC cord-010092-uftc8inx 3554 20 monthly monthly JJ cord-010092-uftc8inx 3554 21 basis basis NN cord-010092-uftc8inx 3554 22 , , , cord-010092-uftc8inx 3554 23 but but CC cord-010092-uftc8inx 3554 24 to to TO cord-010092-uftc8inx 3554 25 also also RB cord-010092-uftc8inx 3554 26 have have VB cord-010092-uftc8inx 3554 27 insight insight NN cord-010092-uftc8inx 3554 28 into into IN cord-010092-uftc8inx 3554 29 variability variability NN cord-010092-uftc8inx 3554 30 in in IN cord-010092-uftc8inx 3554 31 order order NN cord-010092-uftc8inx 3554 32 distribution distribution NN cord-010092-uftc8inx 3554 33 and and CC cord-010092-uftc8inx 3554 34 possible possible JJ cord-010092-uftc8inx 3554 35 attribute attribute NN cord-010092-uftc8inx 3554 36 ( ( -LRB- cord-010092-uftc8inx 3554 37 blood blood NN cord-010092-uftc8inx 3554 38 groups group NNS cord-010092-uftc8inx 3554 39 ) ) -RRB- cord-010092-uftc8inx 3554 40 requirements requirement NNS cord-010092-uftc8inx 3554 41 . . . cord-010092-uftc8inx 3555 1 Since since IN cord-010092-uftc8inx 3555 2 hospitals hospital NNS cord-010092-uftc8inx 3555 3 and and CC cord-010092-uftc8inx 3555 4 blood blood NN cord-010092-uftc8inx 3555 5 banks bank NNS cord-010092-uftc8inx 3555 6 are be VBP cord-010092-uftc8inx 3555 7 usually usually RB cord-010092-uftc8inx 3555 8 not not RB cord-010092-uftc8inx 3555 9 deeply deeply RB cord-010092-uftc8inx 3555 10 interwoven interwoven JJ cord-010092-uftc8inx 3555 11 and and CC cord-010092-uftc8inx 3555 12 often often RB cord-010092-uftc8inx 3555 13 only only RB cord-010092-uftc8inx 3555 14 ex ex JJ cord-010092-uftc8inx 3555 15 - - JJ cord-010092-uftc8inx 3555 16 post post JJ cord-010092-uftc8inx 3555 17 data data NN cord-010092-uftc8inx 3555 18 is be VBZ cord-010092-uftc8inx 3555 19 available available JJ cord-010092-uftc8inx 3555 20 , , , cord-010092-uftc8inx 3555 21 forecasting forecasting NN cord-010092-uftc8inx 3555 22 methods method NNS cord-010092-uftc8inx 3555 23 should should MD cord-010092-uftc8inx 3555 24 be be VB cord-010092-uftc8inx 3555 25 implemented implement VBN cord-010092-uftc8inx 3555 26 . . . cord-010092-uftc8inx 3556 1 A a DT cord-010092-uftc8inx 3556 2 thorough thorough JJ cord-010092-uftc8inx 3556 3 analysis analysis NN cord-010092-uftc8inx 3556 4 of of IN cord-010092-uftc8inx 3556 5 order order NN cord-010092-uftc8inx 3556 6 pattern pattern NN cord-010092-uftc8inx 3556 7 to to TO cord-010092-uftc8inx 3556 8 set set VB cord-010092-uftc8inx 3556 9 weekly weekly JJ cord-010092-uftc8inx 3556 10 target target NN cord-010092-uftc8inx 3556 11 inventories inventory NNS cord-010092-uftc8inx 3556 12 and and CC cord-010092-uftc8inx 3556 13 safety safety NN cord-010092-uftc8inx 3556 14 levels level NNS cord-010092-uftc8inx 3556 15 is be VBZ cord-010092-uftc8inx 3556 16 required require VBN cord-010092-uftc8inx 3556 17 to to TO cord-010092-uftc8inx 3556 18 close close VB cord-010092-uftc8inx 3556 19 the the DT cord-010092-uftc8inx 3556 20 information information NN cord-010092-uftc8inx 3556 21 gap gap NN cord-010092-uftc8inx 3556 22 . . . cord-010092-uftc8inx 3557 1 A a DT cord-010092-uftc8inx 3557 2 collection collection NN cord-010092-uftc8inx 3557 3 plan plan NN cord-010092-uftc8inx 3557 4 needs need VBZ cord-010092-uftc8inx 3557 5 to to TO cord-010092-uftc8inx 3557 6 identify identify VB cord-010092-uftc8inx 3557 7 possible possible JJ cord-010092-uftc8inx 3557 8 bottlenecks bottleneck NNS cord-010092-uftc8inx 3557 9 which which WDT cord-010092-uftc8inx 3557 10 can can MD cord-010092-uftc8inx 3557 11 be be VB cord-010092-uftc8inx 3557 12 prevented prevent VBN cord-010092-uftc8inx 3557 13 through through IN cord-010092-uftc8inx 3557 14 the the DT cord-010092-uftc8inx 3557 15 planning planning NN cord-010092-uftc8inx 3557 16 of of IN cord-010092-uftc8inx 3557 17 inter inter JJ cord-010092-uftc8inx 3557 18 - - JJ cord-010092-uftc8inx 3557 19 shipping shipping JJ cord-010092-uftc8inx 3557 20 , , , cord-010092-uftc8inx 3557 21 changes change NNS cord-010092-uftc8inx 3557 22 in in IN cord-010092-uftc8inx 3557 23 message message NN cord-010092-uftc8inx 3557 24 urgency urgency NN cord-010092-uftc8inx 3557 25 and and CC cord-010092-uftc8inx 3557 26 building building NN cord-010092-uftc8inx 3557 27 of of IN cord-010092-uftc8inx 3557 28 reserve reserve NN cord-010092-uftc8inx 3557 29 donor donor NN cord-010092-uftc8inx 3557 30 pools pool NNS cord-010092-uftc8inx 3557 31 . . . cord-010092-uftc8inx 3558 1 Constant constant JJ cord-010092-uftc8inx 3558 2 analysis analysis NN cord-010092-uftc8inx 3558 3 of of IN cord-010092-uftc8inx 3558 4 collection collection NN cord-010092-uftc8inx 3558 5 and and CC cord-010092-uftc8inx 3558 6 mobilization mobilization NN cord-010092-uftc8inx 3558 7 KPIs kpi NNS cord-010092-uftc8inx 3558 8 allows allow VBZ cord-010092-uftc8inx 3558 9 donor donor NN cord-010092-uftc8inx 3558 10 managers manager NNS cord-010092-uftc8inx 3558 11 to to TO cord-010092-uftc8inx 3558 12 implement implement VB cord-010092-uftc8inx 3558 13 the the DT cord-010092-uftc8inx 3558 14 rolling rolling JJ cord-010092-uftc8inx 3558 15 - - HYPH cord-010092-uftc8inx 3558 16 wave wave NN cord-010092-uftc8inx 3558 17 planning planning NN cord-010092-uftc8inx 3558 18 approach approach NN cord-010092-uftc8inx 3558 19 and and CC cord-010092-uftc8inx 3558 20 continually continually RB cord-010092-uftc8inx 3558 21 adapt adapt VB cord-010092-uftc8inx 3558 22 to to IN cord-010092-uftc8inx 3558 23 changing change VBG cord-010092-uftc8inx 3558 24 requirements requirement NNS cord-010092-uftc8inx 3558 25 , , , cord-010092-uftc8inx 3558 26 unexpected unexpected JJ cord-010092-uftc8inx 3558 27 events event NNS cord-010092-uftc8inx 3558 28 and and CC cord-010092-uftc8inx 3558 29 overall overall JJ cord-010092-uftc8inx 3558 30 systematic systematic JJ cord-010092-uftc8inx 3558 31 variability variability NN cord-010092-uftc8inx 3558 32 . . . cord-010092-uftc8inx 3559 1 The the DT cord-010092-uftc8inx 3559 2 variability variability NN cord-010092-uftc8inx 3559 3 happens happen VBZ cord-010092-uftc8inx 3559 4 on on IN cord-010092-uftc8inx 3559 5 the the DT cord-010092-uftc8inx 3559 6 demand demand NN cord-010092-uftc8inx 3559 7 side side NN cord-010092-uftc8inx 3559 8 , , , cord-010092-uftc8inx 3559 9 as as IN cord-010092-uftc8inx 3559 10 order order NN cord-010092-uftc8inx 3559 11 quantities quantity NNS cord-010092-uftc8inx 3559 12 and and CC cord-010092-uftc8inx 3559 13 their -PRON- PRP$ cord-010092-uftc8inx 3559 14 attributes attribute NNS cord-010092-uftc8inx 3559 15 , , , cord-010092-uftc8inx 3559 16 such such JJ cord-010092-uftc8inx 3559 17 as as IN cord-010092-uftc8inx 3559 18 blood blood NN cord-010092-uftc8inx 3559 19 group group NN cord-010092-uftc8inx 3559 20 distribution distribution NN cord-010092-uftc8inx 3559 21 , , , cord-010092-uftc8inx 3559 22 are be VBP cord-010092-uftc8inx 3559 23 subject subject JJ cord-010092-uftc8inx 3559 24 to to IN cord-010092-uftc8inx 3559 25 change change NN cord-010092-uftc8inx 3559 26 . . . cord-010092-uftc8inx 3560 1 However however RB cord-010092-uftc8inx 3560 2 , , , cord-010092-uftc8inx 3560 3 also also RB cord-010092-uftc8inx 3560 4 the the DT cord-010092-uftc8inx 3560 5 supply supply NN cord-010092-uftc8inx 3560 6 is be VBZ cord-010092-uftc8inx 3560 7 subject subject JJ cord-010092-uftc8inx 3560 8 to to IN cord-010092-uftc8inx 3560 9 significant significant JJ cord-010092-uftc8inx 3560 10 variation variation NN cord-010092-uftc8inx 3560 11 , , , cord-010092-uftc8inx 3560 12 as as IN cord-010092-uftc8inx 3560 13 donor donor NN cord-010092-uftc8inx 3560 14 response response NN cord-010092-uftc8inx 3560 15 rates rate NNS cord-010092-uftc8inx 3560 16 , , , cord-010092-uftc8inx 3560 17 attrition attrition NN cord-010092-uftc8inx 3560 18 , , , cord-010092-uftc8inx 3560 19 deferrals deferral NNS cord-010092-uftc8inx 3560 20 and and CC cord-010092-uftc8inx 3560 21 overall overall JJ cord-010092-uftc8inx 3560 22 availability availability NN cord-010092-uftc8inx 3560 23 of of IN cord-010092-uftc8inx 3560 24 donors donor NNS cord-010092-uftc8inx 3560 25 are be VBP cord-010092-uftc8inx 3560 26 not not RB cord-010092-uftc8inx 3560 27 constant constant JJ cord-010092-uftc8inx 3560 28 . . . cord-010092-uftc8inx 3561 1 The the DT cord-010092-uftc8inx 3561 2 data datum NNS cord-010092-uftc8inx 3561 3 was be VBD cord-010092-uftc8inx 3561 4 collected collect VBN cord-010092-uftc8inx 3561 5 with with IN cord-010092-uftc8inx 3561 6 the the DT cord-010092-uftc8inx 3561 7 face face NN cord-010092-uftc8inx 3561 8 - - HYPH cord-010092-uftc8inx 3561 9 to to IN cord-010092-uftc8inx 3561 10 - - HYPH cord-010092-uftc8inx 3561 11 face face NN cord-010092-uftc8inx 3561 12 interview interview NN cord-010092-uftc8inx 3561 13 method method NN cord-010092-uftc8inx 3561 14 right right RB cord-010092-uftc8inx 3561 15 after after IN cord-010092-uftc8inx 3561 16 the the DT cord-010092-uftc8inx 3561 17 donation donation NN cord-010092-uftc8inx 3561 18 . . . cord-010092-uftc8inx 3562 1 1478 1478 CD cord-010092-uftc8inx 3562 2 first first JJ cord-010092-uftc8inx 3562 3 - - HYPH cord-010092-uftc8inx 3562 4 time time NN cord-010092-uftc8inx 3562 5 donors donor NNS cord-010092-uftc8inx 3562 6 has have VBZ cord-010092-uftc8inx 3562 7 attended attend VBN cord-010092-uftc8inx 3562 8 to to IN cord-010092-uftc8inx 3562 9 the the DT cord-010092-uftc8inx 3562 10 study study NN cord-010092-uftc8inx 3562 11 in in IN cord-010092-uftc8inx 3562 12 18 18 CD cord-010092-uftc8inx 3562 13 Regional Regional NNP cord-010092-uftc8inx 3562 14 Blood Blood NNP cord-010092-uftc8inx 3562 15 Centres Centres NNPS cord-010092-uftc8inx 3562 16 in in IN cord-010092-uftc8inx 3562 17 29 29 CD cord-010092-uftc8inx 3562 18 cities city NNS cord-010092-uftc8inx 3562 19 in in IN cord-010092-uftc8inx 3562 20 Turkey Turkey NNP cord-010092-uftc8inx 3562 21 . . . cord-010092-uftc8inx 3563 1 The the DT cord-010092-uftc8inx 3563 2 survey survey NN cord-010092-uftc8inx 3563 3 included include VBD cord-010092-uftc8inx 3563 4 items item NNS cord-010092-uftc8inx 3563 5 in in IN cord-010092-uftc8inx 3563 6 accordance accordance NN cord-010092-uftc8inx 3563 7 with with IN cord-010092-uftc8inx 3563 8 the the DT cord-010092-uftc8inx 3563 9 standard standard JJ cord-010092-uftc8inx 3563 10 TPB TPB NNP cord-010092-uftc8inx 3563 11 predictors predictor NNS cord-010092-uftc8inx 3563 12 of of IN cord-010092-uftc8inx 3563 13 attitude attitude NN cord-010092-uftc8inx 3563 14 , , , cord-010092-uftc8inx 3563 15 self self NN cord-010092-uftc8inx 3563 16 - - HYPH cord-010092-uftc8inx 3563 17 efficacy efficacy NN cord-010092-uftc8inx 3563 18 , , , cord-010092-uftc8inx 3563 19 and and CC cord-010092-uftc8inx 3563 20 intention intention NN cord-010092-uftc8inx 3563 21 . . . cord-010092-uftc8inx 3564 1 Self self NN cord-010092-uftc8inx 3564 2 - - HYPH cord-010092-uftc8inx 3564 3 identity identity NN cord-010092-uftc8inx 3564 4 , , , cord-010092-uftc8inx 3564 5 anticipated anticipate VBN cord-010092-uftc8inx 3564 6 regret regret NN cord-010092-uftc8inx 3564 7 , , , cord-010092-uftc8inx 3564 8 donation donation NN cord-010092-uftc8inx 3564 9 anxiety anxiety NN cord-010092-uftc8inx 3564 10 , , , cord-010092-uftc8inx 3564 11 paraphernalia paraphernalia NNS cord-010092-uftc8inx 3564 12 anxiety anxiety NN cord-010092-uftc8inx 3564 13 , , , cord-010092-uftc8inx 3564 14 personal personal JJ cord-010092-uftc8inx 3564 15 moral moral JJ cord-010092-uftc8inx 3564 16 norm norm NN cord-010092-uftc8inx 3564 17 , , , cord-010092-uftc8inx 3564 18 descriptive descriptive JJ cord-010092-uftc8inx 3564 19 norm norm NN cord-010092-uftc8inx 3564 20 , , , cord-010092-uftc8inx 3564 21 satisfaction satisfaction NN cord-010092-uftc8inx 3564 22 , , , cord-010092-uftc8inx 3564 23 motivation motivation NN cord-010092-uftc8inx 3564 24 also also RB cord-010092-uftc8inx 3564 25 assessed assess VBD cord-010092-uftc8inx 3564 26 for for IN cord-010092-uftc8inx 3564 27 the the DT cord-010092-uftc8inx 3564 28 first first JJ cord-010092-uftc8inx 3564 29 - - HYPH cord-010092-uftc8inx 3564 30 time time NN cord-010092-uftc8inx 3564 31 donors donor NNS cord-010092-uftc8inx 3564 32 . . . cord-010092-uftc8inx 3565 1 The the DT cord-010092-uftc8inx 3565 2 relation relation NN cord-010092-uftc8inx 3565 3 between between IN cord-010092-uftc8inx 3565 4 the the DT cord-010092-uftc8inx 3565 5 predictors predictor NNS cord-010092-uftc8inx 3565 6 and and CC cord-010092-uftc8inx 3565 7 intention intention NN cord-010092-uftc8inx 3565 8 confirmed confirm VBN cord-010092-uftc8inx 3565 9 with with IN cord-010092-uftc8inx 3565 10 correlation correlation NN cord-010092-uftc8inx 3565 11 analyses analysis NNS cord-010092-uftc8inx 3565 12 . . . cord-010092-uftc8inx 3566 1 The the DT cord-010092-uftc8inx 3566 2 predictors predictor NNS cord-010092-uftc8inx 3566 3 ' ' POS cord-010092-uftc8inx 3566 4 distribution distribution NN cord-010092-uftc8inx 3566 5 analysed analyse VBN cord-010092-uftc8inx 3566 6 by by IN cord-010092-uftc8inx 3566 7 multiple multiple JJ cord-010092-uftc8inx 3566 8 linear linear JJ cord-010092-uftc8inx 3566 9 regression regression NN cord-010092-uftc8inx 3566 10 . . . cord-010092-uftc8inx 3567 1 A a DT cord-010092-uftc8inx 3567 2 number number NN cord-010092-uftc8inx 3567 3 of of IN cord-010092-uftc8inx 3567 4 goodness goodness NN cord-010092-uftc8inx 3567 5 - - HYPH cord-010092-uftc8inx 3567 6 of of IN cord-010092-uftc8inx 3567 7 - - HYPH cord-010092-uftc8inx 3567 8 fit fit JJ cord-010092-uftc8inx 3567 9 indices index NNS cord-010092-uftc8inx 3567 10 were be VBD cord-010092-uftc8inx 3567 11 calculated calculate VBN cord-010092-uftc8inx 3567 12 and and CC cord-010092-uftc8inx 3567 13 examined examine VBN cord-010092-uftc8inx 3567 14 for for IN cord-010092-uftc8inx 3567 15 each each DT cord-010092-uftc8inx 3567 16 tested test VBN cord-010092-uftc8inx 3567 17 models model NNS cord-010092-uftc8inx 3567 18 ( ( -LRB- cord-010092-uftc8inx 3567 19 IBM IBM NNP cord-010092-uftc8inx 3567 20 , , , cord-010092-uftc8inx 3567 21 AMOS AMOS NNP cord-010092-uftc8inx 3567 22 SPSS SPSS NNP cord-010092-uftc8inx 3567 23 ) ) -RRB- cord-010092-uftc8inx 3567 24 . . . cord-010092-uftc8inx 3568 1 The the DT cord-010092-uftc8inx 3568 2 results result NNS cord-010092-uftc8inx 3568 3 of of IN cord-010092-uftc8inx 3568 4 goodnessof goodnessof NNS cord-010092-uftc8inx 3568 5 - - HYPH cord-010092-uftc8inx 3568 6 fit fit JJ cord-010092-uftc8inx 3568 7 tests test NNS cord-010092-uftc8inx 3568 8 for for IN cord-010092-uftc8inx 3568 9 proposed propose VBN cord-010092-uftc8inx 3568 10 model model NN cord-010092-uftc8inx 3568 11 provided provide VBD cord-010092-uftc8inx 3568 12 a a DT cord-010092-uftc8inx 3568 13 better well JJR cord-010092-uftc8inx 3568 14 fit fit NN cord-010092-uftc8inx 3568 15 to to IN cord-010092-uftc8inx 3568 16 the the DT cord-010092-uftc8inx 3568 17 data datum NNS cord-010092-uftc8inx 3568 18 than than IN cord-010092-uftc8inx 3568 19 these these DT cord-010092-uftc8inx 3568 20 models model NNS cord-010092-uftc8inx 3568 21 ( ( -LRB- cord-010092-uftc8inx 3568 22 Cmin Cmin NNP cord-010092-uftc8inx 3568 23 / / SYM cord-010092-uftc8inx 3568 24 Df Df NNP cord-010092-uftc8inx 3568 25 = = SYM cord-010092-uftc8inx 3568 26 14 14 CD cord-010092-uftc8inx 3568 27 ) ) -RRB- cord-010092-uftc8inx 3568 28 . . . cord-010092-uftc8inx 3569 1 Moreover moreover RB cord-010092-uftc8inx 3569 2 , , , cord-010092-uftc8inx 3569 3 this this DT cord-010092-uftc8inx 3569 4 result result NN cord-010092-uftc8inx 3569 5 indicated indicate VBD cord-010092-uftc8inx 3569 6 that that IN cord-010092-uftc8inx 3569 7 the the DT cord-010092-uftc8inx 3569 8 fit fit NN cord-010092-uftc8inx 3569 9 between between IN cord-010092-uftc8inx 3569 10 the the DT cord-010092-uftc8inx 3569 11 proposed propose VBN cord-010092-uftc8inx 3569 12 model model NN cord-010092-uftc8inx 3569 13 and and CC cord-010092-uftc8inx 3569 14 the the DT cord-010092-uftc8inx 3569 15 data datum NNS cord-010092-uftc8inx 3569 16 could could MD cord-010092-uftc8inx 3569 17 be be VB cord-010092-uftc8inx 3569 18 improved improve VBN cord-010092-uftc8inx 3569 19 with with IN cord-010092-uftc8inx 3569 20 further further JJ cord-010092-uftc8inx 3569 21 modifications modification NNS cord-010092-uftc8inx 3569 22 with with IN cord-010092-uftc8inx 3569 23 the the DT cord-010092-uftc8inx 3569 24 inclusion inclusion NN cord-010092-uftc8inx 3569 25 of of IN cord-010092-uftc8inx 3569 26 paths path NNS cord-010092-uftc8inx 3569 27 between between IN cord-010092-uftc8inx 3569 28 motivation motivation NN cord-010092-uftc8inx 3569 29 and and CC cord-010092-uftc8inx 3569 30 attitude attitude NN cord-010092-uftc8inx 3569 31 , , , cord-010092-uftc8inx 3569 32 self self NN cord-010092-uftc8inx 3569 33 - - HYPH cord-010092-uftc8inx 3569 34 identity identity NN cord-010092-uftc8inx 3569 35 and and CC cord-010092-uftc8inx 3569 36 intention intention NN cord-010092-uftc8inx 3569 37 . . . cord-010092-uftc8inx 3570 1 Moreover moreover RB cord-010092-uftc8inx 3570 2 , , , cord-010092-uftc8inx 3570 3 inclusion inclusion NN cord-010092-uftc8inx 3570 4 the the DT cord-010092-uftc8inx 3570 5 paths path NNS cord-010092-uftc8inx 3570 6 between between IN cord-010092-uftc8inx 3570 7 donation donation NN cord-010092-uftc8inx 3570 8 anxiety anxiety NN cord-010092-uftc8inx 3570 9 and and CC cord-010092-uftc8inx 3570 10 intention intention NN cord-010092-uftc8inx 3570 11 and and CC cord-010092-uftc8inx 3570 12 between between IN cord-010092-uftc8inx 3570 13 self self NN cord-010092-uftc8inx 3570 14 - - HYPH cord-010092-uftc8inx 3570 15 efficacy efficacy NN cord-010092-uftc8inx 3570 16 and and CC cord-010092-uftc8inx 3570 17 attitude attitude NN cord-010092-uftc8inx 3570 18 , , , cord-010092-uftc8inx 3570 19 on on IN cord-010092-uftc8inx 3570 20 contrary contrary JJ cord-010092-uftc8inx 3570 21 to to IN cord-010092-uftc8inx 3570 22 recent recent JJ cord-010092-uftc8inx 3570 23 analyses analysis NNS cord-010092-uftc8inx 3570 24 suggesting suggest VBG cord-010092-uftc8inx 3570 25 opposite opposite JJ cord-010092-uftc8inx 3570 26 paths path NNS cord-010092-uftc8inx 3570 27 . . . cord-010092-uftc8inx 3571 1 Evaluation evaluation NN cord-010092-uftc8inx 3571 2 of of IN cord-010092-uftc8inx 3571 3 goodness goodness NN cord-010092-uftc8inx 3571 4 - - HYPH cord-010092-uftc8inx 3571 5 of of IN cord-010092-uftc8inx 3571 6 - - HYPH cord-010092-uftc8inx 3571 7 fit fit JJ cord-010092-uftc8inx 3571 8 tests test NNS cord-010092-uftc8inx 3571 9 showed show VBD cord-010092-uftc8inx 3571 10 good good JJ cord-010092-uftc8inx 3571 11 result result NN cord-010092-uftc8inx 3571 12 for for IN cord-010092-uftc8inx 3571 13 revised revised JJ cord-010092-uftc8inx 3571 14 model model NN cord-010092-uftc8inx 3571 15 with with IN cord-010092-uftc8inx 3571 16 a a DT cord-010092-uftc8inx 3571 17 value value NN cord-010092-uftc8inx 3571 18 of of IN cord-010092-uftc8inx 3571 19 Cmin Cmin NNP cord-010092-uftc8inx 3571 20 / / SYM cord-010092-uftc8inx 3571 21 Df Df NNP cord-010092-uftc8inx 3571 22 = = SYM cord-010092-uftc8inx 3571 23 3.55 3.55 CD cord-010092-uftc8inx 3571 24 , , , cord-010092-uftc8inx 3571 25 close close JJ cord-010092-uftc8inx 3571 26 to to TO cord-010092-uftc8inx 3571 27 perfect perfect JJ cord-010092-uftc8inx 3571 28 fit fit JJ cord-010092-uftc8inx 3571 29 . . . cord-010092-uftc8inx 3572 1 The the DT cord-010092-uftc8inx 3572 2 revised revised JJ cord-010092-uftc8inx 3572 3 model model NN cord-010092-uftc8inx 3572 4 revealed reveal VBD cord-010092-uftc8inx 3572 5 that that IN cord-010092-uftc8inx 3572 6 attitude attitude NN cord-010092-uftc8inx 3572 7 was be VBD cord-010092-uftc8inx 3572 8 the the DT cord-010092-uftc8inx 3572 9 strongest strong JJS cord-010092-uftc8inx 3572 10 positive positive JJ cord-010092-uftc8inx 3572 11 direct direct JJ cord-010092-uftc8inx 3572 12 predictor predictor NN cord-010092-uftc8inx 3572 13 of of IN cord-010092-uftc8inx 3572 14 intention intention NN cord-010092-uftc8inx 3572 15 followed follow VBN cord-010092-uftc8inx 3572 16 by by IN cord-010092-uftc8inx 3572 17 personal personal JJ cord-010092-uftc8inx 3572 18 moral moral JJ cord-010092-uftc8inx 3572 19 norm norm NN cord-010092-uftc8inx 3572 20 , , , cord-010092-uftc8inx 3572 21 self self NN cord-010092-uftc8inx 3572 22 - - HYPH cord-010092-uftc8inx 3572 23 identity identity NN cord-010092-uftc8inx 3572 24 , , , cord-010092-uftc8inx 3572 25 motivation motivation NN cord-010092-uftc8inx 3572 26 and and CC cord-010092-uftc8inx 3572 27 anticipated anticipated JJ cord-010092-uftc8inx 3572 28 regret regret NN cord-010092-uftc8inx 3572 29 ( ( -LRB- cord-010092-uftc8inx 3572 30 path path NN cord-010092-uftc8inx 3572 31 coefficients coefficient NNS cord-010092-uftc8inx 3572 32 : : : cord-010092-uftc8inx 3572 33 0.47 0.47 CD cord-010092-uftc8inx 3572 34 , , , cord-010092-uftc8inx 3572 35 0.28 0.28 CD cord-010092-uftc8inx 3572 36 . . . cord-010092-uftc8inx 3572 37 0.19 0.19 CD cord-010092-uftc8inx 3572 38 , , , cord-010092-uftc8inx 3572 39 0.17 0.17 CD cord-010092-uftc8inx 3572 40 , , , cord-010092-uftc8inx 3572 41 and and CC cord-010092-uftc8inx 3572 42 0.5 0.5 CD cord-010092-uftc8inx 3572 43 , , , cord-010092-uftc8inx 3572 44 respectively respectively RB cord-010092-uftc8inx 3572 45 ) ) -RRB- cord-010092-uftc8inx 3572 46 . . . cord-010092-uftc8inx 3573 1 Donation donation NN cord-010092-uftc8inx 3573 2 anxiety anxiety NN cord-010092-uftc8inx 3573 3 was be VBD cord-010092-uftc8inx 3573 4 the the DT cord-010092-uftc8inx 3573 5 negative negative JJ cord-010092-uftc8inx 3573 6 direct direct JJ cord-010092-uftc8inx 3573 7 predictor predictor NN cord-010092-uftc8inx 3573 8 of of IN cord-010092-uftc8inx 3573 9 intention intention NN cord-010092-uftc8inx 3573 10 ( ( -LRB- cord-010092-uftc8inx 3573 11 -0.05 -0.05 CD cord-010092-uftc8inx 3573 12 ) ) -RRB- cord-010092-uftc8inx 3573 13 . . . cord-010092-uftc8inx 3574 1 Satisfaction satisfaction NN cord-010092-uftc8inx 3574 2 was be VBD cord-010092-uftc8inx 3574 3 the the DT cord-010092-uftc8inx 3574 4 strongest strong JJS cord-010092-uftc8inx 3574 5 positive positive JJ cord-010092-uftc8inx 3574 6 indirect indirect JJ cord-010092-uftc8inx 3574 7 predictor predictor NN cord-010092-uftc8inx 3574 8 of of IN cord-010092-uftc8inx 3574 9 intention intention NN cord-010092-uftc8inx 3574 10 via via IN cord-010092-uftc8inx 3574 11 attitude attitude NN cord-010092-uftc8inx 3574 12 and and CC cord-010092-uftc8inx 3574 13 followed follow VBN cord-010092-uftc8inx 3574 14 by by IN cord-010092-uftc8inx 3574 15 self self NN cord-010092-uftc8inx 3574 16 - - HYPH cord-010092-uftc8inx 3574 17 efficacy efficacy NN cord-010092-uftc8inx 3574 18 ( ( -LRB- cord-010092-uftc8inx 3574 19 0.90 0.90 CD cord-010092-uftc8inx 3574 20 and and CC cord-010092-uftc8inx 3574 21 0.08 0.08 CD cord-010092-uftc8inx 3574 22 ) ) -RRB- cord-010092-uftc8inx 3574 23 . . . cord-010092-uftc8inx 3575 1 Paraphernalia Paraphernalia NNS cord-010092-uftc8inx 3575 2 anxiety anxiety NN cord-010092-uftc8inx 3575 3 was be VBD cord-010092-uftc8inx 3575 4 the the DT cord-010092-uftc8inx 3575 5 negative negative JJ cord-010092-uftc8inx 3575 6 indirect indirect JJ cord-010092-uftc8inx 3575 7 predictor predictor NN cord-010092-uftc8inx 3575 8 of of IN cord-010092-uftc8inx 3575 9 intention intention NN cord-010092-uftc8inx 3575 10 ( ( -LRB- cord-010092-uftc8inx 3575 11 -0.03 -0.03 CD cord-010092-uftc8inx 3575 12 ) ) -RRB- cord-010092-uftc8inx 3575 13 . . . cord-010092-uftc8inx 3576 1 Descriptive descriptive JJ cord-010092-uftc8inx 3576 2 norm norm NN cord-010092-uftc8inx 3576 3 did do VBD cord-010092-uftc8inx 3576 4 not not RB cord-010092-uftc8inx 3576 5 show show VB cord-010092-uftc8inx 3576 6 any any DT cord-010092-uftc8inx 3576 7 significance significance NN cord-010092-uftc8inx 3576 8 . . . cord-010092-uftc8inx 3577 1 Our -PRON- PRP$ cord-010092-uftc8inx 3577 2 model model NN cord-010092-uftc8inx 3577 3 accounted account VBD cord-010092-uftc8inx 3577 4 for for IN cord-010092-uftc8inx 3577 5 75.3 75.3 CD cord-010092-uftc8inx 3577 6 % % NN cord-010092-uftc8inx 3577 7 of of IN cord-010092-uftc8inx 3577 8 the the DT cord-010092-uftc8inx 3577 9 variance variance NN cord-010092-uftc8inx 3577 10 in in IN cord-010092-uftc8inx 3577 11 intention intention NN cord-010092-uftc8inx 3577 12 . . . cord-010092-uftc8inx 3578 1 Summary Summary NNP cord-010092-uftc8inx 3578 2 / / SYM cord-010092-uftc8inx 3578 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 3578 4 : : : cord-010092-uftc8inx 3579 1 These these DT cord-010092-uftc8inx 3579 2 findings finding NNS cord-010092-uftc8inx 3579 3 suggest suggest VBP cord-010092-uftc8inx 3579 4 several several JJ cord-010092-uftc8inx 3579 5 potential potential JJ cord-010092-uftc8inx 3579 6 avenues avenue NNS cord-010092-uftc8inx 3579 7 for for IN cord-010092-uftc8inx 3579 8 enhancing enhance VBG cord-010092-uftc8inx 3579 9 donor donor NN cord-010092-uftc8inx 3579 10 retention retention NN cord-010092-uftc8inx 3579 11 . . . cord-010092-uftc8inx 3580 1 The the DT cord-010092-uftc8inx 3580 2 results result NNS cord-010092-uftc8inx 3580 3 obtained obtain VBN cord-010092-uftc8inx 3580 4 with with IN cord-010092-uftc8inx 3580 5 this this DT cord-010092-uftc8inx 3580 6 study study NN cord-010092-uftc8inx 3580 7 provide provide VB cord-010092-uftc8inx 3580 8 important important JJ cord-010092-uftc8inx 3580 9 data datum NNS cord-010092-uftc8inx 3580 10 from from IN cord-010092-uftc8inx 3580 11 the the DT cord-010092-uftc8inx 3580 12 standpoint standpoint NN cord-010092-uftc8inx 3580 13 of of IN cord-010092-uftc8inx 3580 14 donor donor NN cord-010092-uftc8inx 3580 15 retention retention NN cord-010092-uftc8inx 3580 16 , , , cord-010092-uftc8inx 3580 17 which which WDT cord-010092-uftc8inx 3580 18 should should MD cord-010092-uftc8inx 3580 19 be be VB cord-010092-uftc8inx 3580 20 , , , cord-010092-uftc8inx 3580 21 implemented implement VBN cord-010092-uftc8inx 3580 22 in in IN cord-010092-uftc8inx 3580 23 the the DT cord-010092-uftc8inx 3580 24 future future JJ cord-010092-uftc8inx 3580 25 strategies strategy NNS cord-010092-uftc8inx 3580 26 of of IN cord-010092-uftc8inx 3580 27 Turkish turkish JJ cord-010092-uftc8inx 3580 28 Red Red NNP cord-010092-uftc8inx 3580 29 Crescent Crescent NNP cord-010092-uftc8inx 3580 30 . . . cord-010092-uftc8inx 3580 31 _SP cord-010092-uftc8inx 3581 1 Background background NN cord-010092-uftc8inx 3581 2 : : : cord-010092-uftc8inx 3581 3 TRANSPOSE transpose VB cord-010092-uftc8inx 3581 4 - - HYPH cord-010092-uftc8inx 3581 5 TRANSfusion transfusion NN cord-010092-uftc8inx 3581 6 and and CC cord-010092-uftc8inx 3581 7 transplantation transplantation NN cord-010092-uftc8inx 3581 8 : : : cord-010092-uftc8inx 3581 9 PrOtection PrOtection NNP cord-010092-uftc8inx 3581 10 and and CC cord-010092-uftc8inx 3581 11 SElection SElection NNP cord-010092-uftc8inx 3581 12 of of IN cord-010092-uftc8inx 3581 13 donors donor NNS cord-010092-uftc8inx 3581 14 , , , cord-010092-uftc8inx 3581 15 is be VBZ cord-010092-uftc8inx 3581 16 a a DT cord-010092-uftc8inx 3581 17 European european JJ cord-010092-uftc8inx 3581 18 consortium consortium NN cord-010092-uftc8inx 3581 19 project project NN cord-010092-uftc8inx 3581 20 , , , cord-010092-uftc8inx 3581 21 including include VBG cord-010092-uftc8inx 3581 22 partners partner NNS cord-010092-uftc8inx 3581 23 from from IN cord-010092-uftc8inx 3581 24 16 16 CD cord-010092-uftc8inx 3581 25 countries country NNS cord-010092-uftc8inx 3581 26 , , , cord-010092-uftc8inx 3581 27 reviewing review VBG cord-010092-uftc8inx 3581 28 donor donor NN cord-010092-uftc8inx 3581 29 selection selection NN cord-010092-uftc8inx 3581 30 and and CC cord-010092-uftc8inx 3581 31 protection protection NN cord-010092-uftc8inx 3581 32 policies policy NNS cord-010092-uftc8inx 3581 33 for for IN cord-010092-uftc8inx 3581 34 substances substance NNS cord-010092-uftc8inx 3581 35 of of IN cord-010092-uftc8inx 3581 36 human human JJ cord-010092-uftc8inx 3581 37 origin origin NN cord-010092-uftc8inx 3581 38 ( ( -LRB- cord-010092-uftc8inx 3581 39 SoHO).One SoHO).One NNP cord-010092-uftc8inx 3581 40 of of IN cord-010092-uftc8inx 3581 41 the the DT cord-010092-uftc8inx 3581 42 main main JJ cord-010092-uftc8inx 3581 43 issues issue NNS cord-010092-uftc8inx 3581 44 in in IN cord-010092-uftc8inx 3581 45 the the DT cord-010092-uftc8inx 3581 46 current current JJ cord-010092-uftc8inx 3581 47 donor donor NN cord-010092-uftc8inx 3581 48 selection selection NN cord-010092-uftc8inx 3581 49 system system NN cord-010092-uftc8inx 3581 50 , , , cord-010092-uftc8inx 3581 51 which which WDT cord-010092-uftc8inx 3581 52 TRANSPOSE transpose VBP cord-010092-uftc8inx 3581 53 aims aim VBZ cord-010092-uftc8inx 3581 54 to to TO cord-010092-uftc8inx 3581 55 tackle tackle VB cord-010092-uftc8inx 3581 56 , , , cord-010092-uftc8inx 3581 57 is be VBZ cord-010092-uftc8inx 3581 58 that that DT cord-010092-uftc8inx 3581 59 for for IN cord-010092-uftc8inx 3581 60 many many JJ cord-010092-uftc8inx 3581 61 , , , cord-010092-uftc8inx 3581 62 if if IN cord-010092-uftc8inx 3581 63 not not RB cord-010092-uftc8inx 3581 64 most most JJS cord-010092-uftc8inx 3581 65 criteria criterion NNS cord-010092-uftc8inx 3581 66 , , , cord-010092-uftc8inx 3581 67 is be VBZ cord-010092-uftc8inx 3581 68 not not RB cord-010092-uftc8inx 3581 69 evidence evidence NN cord-010092-uftc8inx 3581 70 based base VBN cord-010092-uftc8inx 3581 71 . . . cord-010092-uftc8inx 3582 1 The the DT cord-010092-uftc8inx 3582 2 TRANSPOSE transpose NN cord-010092-uftc8inx 3582 3 consortium consortium NN cord-010092-uftc8inx 3582 4 therefore therefore RB cord-010092-uftc8inx 3582 5 tries try VBZ cord-010092-uftc8inx 3582 6 to to TO cord-010092-uftc8inx 3582 7 re re VB cord-010092-uftc8inx 3582 8 - - VB cord-010092-uftc8inx 3582 9 assess assess VB cord-010092-uftc8inx 3582 10 selection selection NN cord-010092-uftc8inx 3582 11 criteria criterion NNS cord-010092-uftc8inx 3582 12 , , , cord-010092-uftc8inx 3582 13 revised revise VBD cord-010092-uftc8inx 3582 14 them -PRON- PRP cord-010092-uftc8inx 3582 15 where where WRB cord-010092-uftc8inx 3582 16 needed need VBN cord-010092-uftc8inx 3582 17 and and CC cord-010092-uftc8inx 3582 18 provide provide VB cord-010092-uftc8inx 3582 19 recommendations recommendation NNS cord-010092-uftc8inx 3582 20 as as IN cord-010092-uftc8inx 3582 21 evidence evidence NN cord-010092-uftc8inx 3582 22 - - HYPH cord-010092-uftc8inx 3582 23 based base VBN cord-010092-uftc8inx 3582 24 as as IN cord-010092-uftc8inx 3582 25 possible possible JJ cord-010092-uftc8inx 3582 26 . . . cord-010092-uftc8inx 3583 1 TRANSPOSE transpose VB cord-010092-uftc8inx 3583 2 additionally additionally RB cord-010092-uftc8inx 3583 3 adds add VBZ cord-010092-uftc8inx 3583 4 to to IN cord-010092-uftc8inx 3583 5 the the DT cord-010092-uftc8inx 3583 6 current current JJ cord-010092-uftc8inx 3583 7 European European NNP cord-010092-uftc8inx 3583 8 Directorate Directorate NNP cord-010092-uftc8inx 3583 9 for for IN cord-010092-uftc8inx 3583 10 the the DT cord-010092-uftc8inx 3583 11 Quality Quality NNP cord-010092-uftc8inx 3583 12 of of IN cord-010092-uftc8inx 3583 13 Medicines Medicines NNP cord-010092-uftc8inx 3583 14 & & CC cord-010092-uftc8inx 3583 15 HealthCare HealthCare NNP cord-010092-uftc8inx 3583 16 ( ( -LRB- cord-010092-uftc8inx 3583 17 EDQM EDQM NNP cord-010092-uftc8inx 3583 18 ) ) -RRB- cord-010092-uftc8inx 3583 19 Guidelines guideline NNS cord-010092-uftc8inx 3583 20 by by IN cord-010092-uftc8inx 3583 21 emphasizing emphasize VBG cord-010092-uftc8inx 3583 22 donor donor NN cord-010092-uftc8inx 3583 23 safety safety NN cord-010092-uftc8inx 3583 24 . . . cord-010092-uftc8inx 3584 1 Aims aim VBZ cord-010092-uftc8inx 3584 2 : : : cord-010092-uftc8inx 3585 1 The the DT cord-010092-uftc8inx 3585 2 aim aim NN cord-010092-uftc8inx 3585 3 is be VBZ cord-010092-uftc8inx 3585 4 to to TO cord-010092-uftc8inx 3585 5 compare compare VB cord-010092-uftc8inx 3585 6 existing exist VBG cord-010092-uftc8inx 3585 7 donor donor NN cord-010092-uftc8inx 3585 8 eligibility eligibility NN cord-010092-uftc8inx 3585 9 criteria criterion NNS cord-010092-uftc8inx 3585 10 throughout throughout IN cord-010092-uftc8inx 3585 11 Europe Europe NNP cord-010092-uftc8inx 3585 12 , , , cord-010092-uftc8inx 3585 13 and and CC cord-010092-uftc8inx 3585 14 to to TO cord-010092-uftc8inx 3585 15 compile compile VB cord-010092-uftc8inx 3585 16 a a DT cord-010092-uftc8inx 3585 17 list list NN cord-010092-uftc8inx 3585 18 of of IN cord-010092-uftc8inx 3585 19 risks risk NNS cord-010092-uftc8inx 3585 20 to to TO cord-010092-uftc8inx 3585 21 consider consider VB cord-010092-uftc8inx 3585 22 , , , cord-010092-uftc8inx 3585 23 with with IN cord-010092-uftc8inx 3585 24 evidence evidence NN cord-010092-uftc8inx 3585 25 - - HYPH cord-010092-uftc8inx 3585 26 or or CC cord-010092-uftc8inx 3585 27 consensus consensus NN cord-010092-uftc8inx 3585 28 - - HYPH cord-010092-uftc8inx 3585 29 based base VBN cord-010092-uftc8inx 3585 30 deferral deferral NN cord-010092-uftc8inx 3585 31 criteria criterion NNS cord-010092-uftc8inx 3585 32 to to TO cord-010092-uftc8inx 3585 33 provide provide VB cord-010092-uftc8inx 3585 34 more more JJR cord-010092-uftc8inx 3585 35 uniform uniform JJ cord-010092-uftc8inx 3585 36 donor donor NN cord-010092-uftc8inx 3585 37 screening screening NN cord-010092-uftc8inx 3585 38 criteria criterion NNS cord-010092-uftc8inx 3585 39 . . . cord-010092-uftc8inx 3586 1 Methods method NNS cord-010092-uftc8inx 3586 2 : : : cord-010092-uftc8inx 3586 3 There there EX cord-010092-uftc8inx 3586 4 are be VBP cord-010092-uftc8inx 3586 5 three three CD cord-010092-uftc8inx 3586 6 horizontal horizontal JJ cord-010092-uftc8inx 3586 7 work work NN cord-010092-uftc8inx 3586 8 - - HYPH cord-010092-uftc8inx 3586 9 packages package NNS cord-010092-uftc8inx 3586 10 ( ( -LRB- cord-010092-uftc8inx 3586 11 WPs WPs NNP cord-010092-uftc8inx 3586 12 ) ) -RRB- cord-010092-uftc8inx 3586 13 ; ; : cord-010092-uftc8inx 3586 14 WP1 WP1 NNP cord-010092-uftc8inx 3586 15 Coordination Coordination NNP cord-010092-uftc8inx 3586 16 , , , cord-010092-uftc8inx 3586 17 WP2 WP2 NNP cord-010092-uftc8inx 3586 18 Dissemination Dissemination NNP cord-010092-uftc8inx 3586 19 , , , cord-010092-uftc8inx 3586 20 and and CC cord-010092-uftc8inx 3586 21 WP3 WP3 NNP cord-010092-uftc8inx 3586 22 Evaluation Evaluation NNP cord-010092-uftc8inx 3586 23 of of IN cord-010092-uftc8inx 3586 24 the the DT cord-010092-uftc8inx 3586 25 project project NN cord-010092-uftc8inx 3586 26 , , , cord-010092-uftc8inx 3586 27 and and CC cord-010092-uftc8inx 3586 28 four four CD cord-010092-uftc8inx 3586 29 technical technical JJ cord-010092-uftc8inx 3586 30 ones one NNS cord-010092-uftc8inx 3586 31 with with IN cord-010092-uftc8inx 3586 32 specific specific JJ cord-010092-uftc8inx 3586 33 deliverables deliverable NNS cord-010092-uftc8inx 3586 34 and and CC cord-010092-uftc8inx 3586 35 milestones milestone NNS cord-010092-uftc8inx 3586 36 to to TO cord-010092-uftc8inx 3586 37 be be VB cord-010092-uftc8inx 3586 38 regularly regularly RB cord-010092-uftc8inx 3586 39 produced produce VBN cord-010092-uftc8inx 3586 40 : : : cord-010092-uftc8inx 3587 1 -WP4 -WP4 NNP cord-010092-uftc8inx 3587 2 Inventory Inventory NNP cord-010092-uftc8inx 3587 3 of of IN cord-010092-uftc8inx 3587 4 Donor Donor NNP cord-010092-uftc8inx 3587 5 Selection Selection NNP cord-010092-uftc8inx 3587 6 & & CC cord-010092-uftc8inx 3587 7 Protection Protection NNP cord-010092-uftc8inx 3587 8 Practices Practices NNPS cord-010092-uftc8inx 3587 9 ; ; : cord-010092-uftc8inx 3588 1 -WP5 -WP5 . cord-010092-uftc8inx 3589 1 Development development NN cord-010092-uftc8inx 3589 2 of of IN cord-010092-uftc8inx 3589 3 risk risk NN cord-010092-uftc8inx 3589 4 - - HYPH cord-010092-uftc8inx 3589 5 based base VBN cord-010092-uftc8inx 3589 6 Guidelines guideline NNS cord-010092-uftc8inx 3589 7 for for IN cord-010092-uftc8inx 3589 8 donor donor NN cord-010092-uftc8inx 3589 9 selection selection NN cord-010092-uftc8inx 3589 10 and and CC cord-010092-uftc8inx 3589 11 protection protection NN cord-010092-uftc8inx 3589 12 ; ; : cord-010092-uftc8inx 3590 1 -WP6 -WP6 : cord-010092-uftc8inx 3590 2 Development Development NNP cord-010092-uftc8inx 3590 3 of of IN cord-010092-uftc8inx 3590 4 a a DT cord-010092-uftc8inx 3590 5 Standard Standard NNP cord-010092-uftc8inx 3590 6 Donor Donor NNP cord-010092-uftc8inx 3590 7 Health Health NNP cord-010092-uftc8inx 3590 8 Questionnaire Questionnaire NNP cord-010092-uftc8inx 3590 9 ( ( -LRB- cord-010092-uftc8inx 3590 10 DHQ DHQ NNP cord-010092-uftc8inx 3590 11 ) ) -RRB- cord-010092-uftc8inx 3590 12 ; ; : cord-010092-uftc8inx 3591 1 -WP7 -wp7 RB cord-010092-uftc8inx 3592 1 Training Training NNP cord-010092-uftc8inx 3592 2 Course course NN cord-010092-uftc8inx 3592 3 / / SYM cord-010092-uftc8inx 3592 4 Workshop Workshop NNP cord-010092-uftc8inx 3592 5 on on IN cord-010092-uftc8inx 3592 6 the the DT cord-010092-uftc8inx 3592 7 Use Use NNP cord-010092-uftc8inx 3592 8 of of IN cord-010092-uftc8inx 3592 9 the the DT cord-010092-uftc8inx 3592 10 Guiding Guiding NNP cord-010092-uftc8inx 3592 11 Principles Principles NNPS cord-010092-uftc8inx 3592 12 , , , cord-010092-uftc8inx 3592 13 Guidelines Guidelines NNPS cord-010092-uftc8inx 3592 14 and and CC cord-010092-uftc8inx 3592 15 the the DT cord-010092-uftc8inx 3592 16 DHQ dhq NN cord-010092-uftc8inx 3592 17 . . . cord-010092-uftc8inx 3593 1 The the DT cord-010092-uftc8inx 3593 2 TRANSPOSE transpose NN cord-010092-uftc8inx 3593 3 project project NN cord-010092-uftc8inx 3593 4 launched launch VBN cord-010092-uftc8inx 3593 5 in in IN cord-010092-uftc8inx 3593 6 September September NNP cord-010092-uftc8inx 3593 7 2017 2017 CD cord-010092-uftc8inx 3593 8 and and CC cord-010092-uftc8inx 3593 9 will will MD cord-010092-uftc8inx 3593 10 complete complete VB cord-010092-uftc8inx 3593 11 in in IN cord-010092-uftc8inx 3593 12 Spring Spring NNP cord-010092-uftc8inx 3593 13 2020 2020 CD cord-010092-uftc8inx 3593 14 . . . cord-010092-uftc8inx 3594 1 WP4 WP4 NNP cord-010092-uftc8inx 3594 2 has have VBZ cord-010092-uftc8inx 3594 3 completed complete VBN cord-010092-uftc8inx 3594 4 its -PRON- PRP$ cord-010092-uftc8inx 3594 5 work work NN cord-010092-uftc8inx 3594 6 in in IN cord-010092-uftc8inx 3594 7 October October NNP cord-010092-uftc8inx 3594 8 , , , cord-010092-uftc8inx 3594 9 WP5 WP5 NNS cord-010092-uftc8inx 3594 10 will will MD cord-010092-uftc8inx 3594 11 complete complete VB cord-010092-uftc8inx 3594 12 its -PRON- PRP$ cord-010092-uftc8inx 3594 13 work work NN cord-010092-uftc8inx 3594 14 in in IN cord-010092-uftc8inx 3594 15 June June NNP cord-010092-uftc8inx 3594 16 2019 2019 CD cord-010092-uftc8inx 3594 17 , , , cord-010092-uftc8inx 3594 18 and and CC cord-010092-uftc8inx 3594 19 WP6 WP6 NNP cord-010092-uftc8inx 3594 20 and and CC cord-010092-uftc8inx 3594 21 WP7 WP7 NNP cord-010092-uftc8inx 3594 22 have have VBP cord-010092-uftc8inx 3594 23 recently recently RB cord-010092-uftc8inx 3594 24 commenced commence VBN cord-010092-uftc8inx 3594 25 . . . cord-010092-uftc8inx 3595 1 Results result NNS cord-010092-uftc8inx 3595 2 : : : cord-010092-uftc8inx 3596 1 With with IN cord-010092-uftc8inx 3596 2 the the DT cord-010092-uftc8inx 3596 3 use use NN cord-010092-uftc8inx 3596 4 of of IN cord-010092-uftc8inx 3596 5 the the DT cord-010092-uftc8inx 3596 6 deliverables deliverable NNS cord-010092-uftc8inx 3596 7 created create VBN cord-010092-uftc8inx 3596 8 by by IN cord-010092-uftc8inx 3596 9 WP4 WP4 NNP cord-010092-uftc8inx 3596 10 , , , cord-010092-uftc8inx 3596 11 we -PRON- PRP cord-010092-uftc8inx 3596 12 have have VBP cord-010092-uftc8inx 3596 13 created create VBN cord-010092-uftc8inx 3596 14 an an DT cord-010092-uftc8inx 3596 15 indepth indepth JJ cord-010092-uftc8inx 3596 16 inventory inventory NN cord-010092-uftc8inx 3596 17 of of IN cord-010092-uftc8inx 3596 18 current current JJ cord-010092-uftc8inx 3596 19 practices practice NNS cord-010092-uftc8inx 3596 20 in in IN cord-010092-uftc8inx 3596 21 donor donor NN cord-010092-uftc8inx 3596 22 selection selection NN cord-010092-uftc8inx 3596 23 and and CC cord-010092-uftc8inx 3596 24 protection protection NN cord-010092-uftc8inx 3596 25 , , , cord-010092-uftc8inx 3596 26 including include VBG cord-010092-uftc8inx 3596 27 overview overview NN cord-010092-uftc8inx 3596 28 of of IN cord-010092-uftc8inx 3596 29 similarities similarity NNS cord-010092-uftc8inx 3596 30 and and CC cord-010092-uftc8inx 3596 31 differences difference NNS cord-010092-uftc8inx 3596 32 across across IN cord-010092-uftc8inx 3596 33 European european JJ cord-010092-uftc8inx 3596 34 countries country NNS cord-010092-uftc8inx 3596 35 and and CC cord-010092-uftc8inx 3596 36 across across IN cord-010092-uftc8inx 3596 37 SoHO SoHO NNP cord-010092-uftc8inx 3596 38 types type NNS cord-010092-uftc8inx 3596 39 . . . cord-010092-uftc8inx 3597 1 There there EX cord-010092-uftc8inx 3597 2 is be VBZ cord-010092-uftc8inx 3597 3 an an DT cord-010092-uftc8inx 3597 4 agreement agreement NN cord-010092-uftc8inx 3597 5 amongst amongst IN cord-010092-uftc8inx 3597 6 experts expert NNS cord-010092-uftc8inx 3597 7 that that IN cord-010092-uftc8inx 3597 8 existing exist VBG cord-010092-uftc8inx 3597 9 guidelines guideline NNS cord-010092-uftc8inx 3597 10 are be VBP cord-010092-uftc8inx 3597 11 often often RB cord-010092-uftc8inx 3597 12 based base VBN cord-010092-uftc8inx 3597 13 on on IN cord-010092-uftc8inx 3597 14 the the DT cord-010092-uftc8inx 3597 15 precautionary precautionary JJ cord-010092-uftc8inx 3597 16 principle principle NN cord-010092-uftc8inx 3597 17 rather rather RB cord-010092-uftc8inx 3597 18 than than IN cord-010092-uftc8inx 3597 19 on on IN cord-010092-uftc8inx 3597 20 risk risk NN cord-010092-uftc8inx 3597 21 assessment assessment NN cord-010092-uftc8inx 3597 22 . . . cord-010092-uftc8inx 3598 1 Consequently consequently RB cord-010092-uftc8inx 3598 2 , , , cord-010092-uftc8inx 3598 3 in in IN cord-010092-uftc8inx 3598 4 the the DT cord-010092-uftc8inx 3598 5 development development NN cord-010092-uftc8inx 3598 6 of of IN cord-010092-uftc8inx 3598 7 WP5 WP5 NNP cord-010092-uftc8inx 3598 8 's 's POS cord-010092-uftc8inx 3598 9 Guidelines Guidelines NNPS cord-010092-uftc8inx 3598 10 for for IN cord-010092-uftc8inx 3598 11 donor donor NN cord-010092-uftc8inx 3598 12 selection selection NN cord-010092-uftc8inx 3598 13 and and CC cord-010092-uftc8inx 3598 14 protection protection NN cord-010092-uftc8inx 3598 15 , , , cord-010092-uftc8inx 3598 16 we -PRON- PRP cord-010092-uftc8inx 3598 17 now now RB cord-010092-uftc8inx 3598 18 make make VBP cord-010092-uftc8inx 3598 19 an an DT cord-010092-uftc8inx 3598 20 effort effort NN cord-010092-uftc8inx 3598 21 to to TO cord-010092-uftc8inx 3598 22 also also RB cord-010092-uftc8inx 3598 23 emphasize emphasize VB cord-010092-uftc8inx 3598 24 donor donor NN cord-010092-uftc8inx 3598 25 safety safety NN cord-010092-uftc8inx 3598 26 , , , cord-010092-uftc8inx 3598 27 in in IN cord-010092-uftc8inx 3598 28 a a DT cord-010092-uftc8inx 3598 29 more more JJR cord-010092-uftc8inx 3598 30 evidence evidence NN cord-010092-uftc8inx 3598 31 - - HYPH cord-010092-uftc8inx 3598 32 based base VBN cord-010092-uftc8inx 3598 33 way way NN cord-010092-uftc8inx 3598 34 via via IN cord-010092-uftc8inx 3598 35 the the DT cord-010092-uftc8inx 3598 36 use use NN cord-010092-uftc8inx 3598 37 of of IN cord-010092-uftc8inx 3598 38 risk risk NN cord-010092-uftc8inx 3598 39 - - HYPH cord-010092-uftc8inx 3598 40 based base VBN cord-010092-uftc8inx 3598 41 assessments assessment NNS cord-010092-uftc8inx 3598 42 . . . cord-010092-uftc8inx 3599 1 This this DT cord-010092-uftc8inx 3599 2 will will MD cord-010092-uftc8inx 3599 3 result result VB cord-010092-uftc8inx 3599 4 in in IN cord-010092-uftc8inx 3599 5 a a DT cord-010092-uftc8inx 3599 6 standardized standardized JJ cord-010092-uftc8inx 3599 7 DHQ dhq NN cord-010092-uftc8inx 3599 8 with with IN cord-010092-uftc8inx 3599 9 a a DT cord-010092-uftc8inx 3599 10 common common JJ cord-010092-uftc8inx 3599 11 trunk trunk NN cord-010092-uftc8inx 3599 12 and and CC cord-010092-uftc8inx 3599 13 more more JJR cord-010092-uftc8inx 3599 14 in in IN cord-010092-uftc8inx 3599 15 -depth -depth NN cord-010092-uftc8inx 3599 16 questions question NNS cord-010092-uftc8inx 3599 17 per per IN cord-010092-uftc8inx 3599 18 SoHO soho NN cord-010092-uftc8inx 3599 19 . . . cord-010092-uftc8inx 3600 1 Summary Summary NNP cord-010092-uftc8inx 3600 2 / / SYM cord-010092-uftc8inx 3600 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 3600 4 : : : cord-010092-uftc8inx 3601 1 The the DT cord-010092-uftc8inx 3601 2 impact impact NN cord-010092-uftc8inx 3601 3 of of IN cord-010092-uftc8inx 3601 4 the the DT cord-010092-uftc8inx 3601 5 outcomes outcome NNS cord-010092-uftc8inx 3601 6 of of IN cord-010092-uftc8inx 3601 7 TRANSPOSE transpose NN cord-010092-uftc8inx 3601 8 will will MD cord-010092-uftc8inx 3601 9 be be VB cord-010092-uftc8inx 3601 10 threefold threefold JJ cord-010092-uftc8inx 3601 11 . . . cord-010092-uftc8inx 3602 1 First first RB cord-010092-uftc8inx 3602 2 , , , cord-010092-uftc8inx 3602 3 outcomes outcome NNS cord-010092-uftc8inx 3602 4 are be VBP cord-010092-uftc8inx 3602 5 expected expect VBN cord-010092-uftc8inx 3602 6 to to TO cord-010092-uftc8inx 3602 7 be be VB cord-010092-uftc8inx 3602 8 of of IN cord-010092-uftc8inx 3602 9 help help NN cord-010092-uftc8inx 3602 10 in in IN cord-010092-uftc8inx 3602 11 revising revise VBG cord-010092-uftc8inx 3602 12 donor donor NN cord-010092-uftc8inx 3602 13 selection selection NN cord-010092-uftc8inx 3602 14 and and CC cord-010092-uftc8inx 3602 15 protection protection NN cord-010092-uftc8inx 3602 16 related relate VBN cord-010092-uftc8inx 3602 17 EU EU NNP cord-010092-uftc8inx 3602 18 Directives directive NNS cord-010092-uftc8inx 3602 19 . . . cord-010092-uftc8inx 3603 1 Second second RB cord-010092-uftc8inx 3603 2 , , , cord-010092-uftc8inx 3603 3 the the DT cord-010092-uftc8inx 3603 4 set set NN cord-010092-uftc8inx 3603 5 of of IN cord-010092-uftc8inx 3603 6 guiding guide VBG cord-010092-uftc8inx 3603 7 principles principle NNS cord-010092-uftc8inx 3603 8 and and CC cord-010092-uftc8inx 3603 9 Donor Donor NNP cord-010092-uftc8inx 3603 10 Selection Selection NNP cord-010092-uftc8inx 3603 11 & & CC cord-010092-uftc8inx 3603 12 Protection Protection NNP cord-010092-uftc8inx 3603 13 Guidelines Guidelines NNPS cord-010092-uftc8inx 3603 14 will will MD cord-010092-uftc8inx 3603 15 facilitate facilitate VB cord-010092-uftc8inx 3603 16 EU EU NNP cord-010092-uftc8inx 3603 17 member member NN cord-010092-uftc8inx 3603 18 states state NNS cord-010092-uftc8inx 3603 19 to to TO cord-010092-uftc8inx 3603 20 take take VB cord-010092-uftc8inx 3603 21 a a DT cord-010092-uftc8inx 3603 22 next next JJ cord-010092-uftc8inx 3603 23 step step NN cord-010092-uftc8inx 3603 24 in in IN cord-010092-uftc8inx 3603 25 implementing implement VBG cord-010092-uftc8inx 3603 26 donor donor NN cord-010092-uftc8inx 3603 27 selection selection NN cord-010092-uftc8inx 3603 28 and and CC cord-010092-uftc8inx 3603 29 protection protection NN cord-010092-uftc8inx 3603 30 policies policy NNS cord-010092-uftc8inx 3603 31 in in IN cord-010092-uftc8inx 3603 32 a a DT cord-010092-uftc8inx 3603 33 consistent consistent JJ cord-010092-uftc8inx 3603 34 and and CC cord-010092-uftc8inx 3603 35 clear clear RB cord-010092-uftc8inx 3603 36 - - HYPH cord-010092-uftc8inx 3603 37 cut cut VBN cord-010092-uftc8inx 3603 38 way way NN cord-010092-uftc8inx 3603 39 to to IN cord-010092-uftc8inx 3603 40 the the DT cord-010092-uftc8inx 3603 41 benefit benefit NN cord-010092-uftc8inx 3603 42 of of IN cord-010092-uftc8inx 3603 43 both both DT cord-010092-uftc8inx 3603 44 donors donor NNS cord-010092-uftc8inx 3603 45 and and CC cord-010092-uftc8inx 3603 46 recipients recipient NNS cord-010092-uftc8inx 3603 47 of of IN cord-010092-uftc8inx 3603 48 SoHO SoHO NNP cord-010092-uftc8inx 3603 49 . . . cord-010092-uftc8inx 3604 1 Third third RB cord-010092-uftc8inx 3604 2 , , , cord-010092-uftc8inx 3604 3 a a DT cord-010092-uftc8inx 3604 4 standard standard JJ cord-010092-uftc8inx 3604 5 Donor Donor NNP cord-010092-uftc8inx 3604 6 Health Health NNP cord-010092-uftc8inx 3604 7 Questionnaire Questionnaire NNP cord-010092-uftc8inx 3604 8 with with IN cord-010092-uftc8inx 3604 9 carefully carefully RB cord-010092-uftc8inx 3604 10 guided guide VBN cord-010092-uftc8inx 3604 11 local local JJ cord-010092-uftc8inx 3604 12 / / SYM cord-010092-uftc8inx 3604 13 regional regional JJ cord-010092-uftc8inx 3604 14 / / SYM cord-010092-uftc8inx 3604 15 national national JJ cord-010092-uftc8inx 3604 16 adjustments adjustment NNS cord-010092-uftc8inx 3604 17 will will MD cord-010092-uftc8inx 3604 18 become become VB cord-010092-uftc8inx 3604 19 available available JJ cord-010092-uftc8inx 3604 20 per per IN cord-010092-uftc8inx 3604 21 SoHO soho NN cord-010092-uftc8inx 3604 22 which which WDT cord-010092-uftc8inx 3604 23 can can MD cord-010092-uftc8inx 3604 24 be be VB cord-010092-uftc8inx 3604 25 used use VBN cord-010092-uftc8inx 3604 26 widely widely RB cord-010092-uftc8inx 3604 27 and and CC cord-010092-uftc8inx 3604 28 will will MD cord-010092-uftc8inx 3604 29 consequently consequently RB cord-010092-uftc8inx 3604 30 enable enable VB cord-010092-uftc8inx 3604 31 comparisons comparison NNS cord-010092-uftc8inx 3604 32 of of IN cord-010092-uftc8inx 3604 33 the the DT cord-010092-uftc8inx 3604 34 prevalence prevalence NN cord-010092-uftc8inx 3604 35 of of IN cord-010092-uftc8inx 3604 36 certain certain JJ cord-010092-uftc8inx 3604 37 risks risk NNS cord-010092-uftc8inx 3604 38 and and CC cord-010092-uftc8inx 3604 39 risky risky JJ cord-010092-uftc8inx 3604 40 behaviours behaviour NNS cord-010092-uftc8inx 3604 41 throughout throughout IN cord-010092-uftc8inx 3604 42 Europe Europe NNP cord-010092-uftc8inx 3604 43 . . . cord-010092-uftc8inx 3605 1 Background background NN cord-010092-uftc8inx 3605 2 : : : cord-010092-uftc8inx 3606 1 TRANSPOSE transpose VB cord-010092-uftc8inx 3606 2 - - HYPH cord-010092-uftc8inx 3606 3 TRANSfusion transfusion NN cord-010092-uftc8inx 3606 4 and and CC cord-010092-uftc8inx 3606 5 transplantation transplantation NN cord-010092-uftc8inx 3606 6 PrOtection PrOtection NNP cord-010092-uftc8inx 3606 7 and and CC cord-010092-uftc8inx 3606 8 SElection SElection NNP cord-010092-uftc8inx 3606 9 of of IN cord-010092-uftc8inx 3606 10 donors donor NNS cord-010092-uftc8inx 3606 11 is be VBZ cord-010092-uftc8inx 3606 12 a a DT cord-010092-uftc8inx 3606 13 European european JJ cord-010092-uftc8inx 3606 14 consortium consortium NN cord-010092-uftc8inx 3606 15 project project NN cord-010092-uftc8inx 3606 16 , , , cord-010092-uftc8inx 3606 17 including include VBG cord-010092-uftc8inx 3606 18 partners partner NNS cord-010092-uftc8inx 3606 19 from from IN cord-010092-uftc8inx 3606 20 16 16 CD cord-010092-uftc8inx 3606 21 countries country NNS cord-010092-uftc8inx 3606 22 , , , cord-010092-uftc8inx 3606 23 that that IN cord-010092-uftc8inx 3606 24 reviews review VBZ cord-010092-uftc8inx 3606 25 donor donor NN cord-010092-uftc8inx 3606 26 selection selection NN cord-010092-uftc8inx 3606 27 and and CC cord-010092-uftc8inx 3606 28 protection protection NN cord-010092-uftc8inx 3606 29 policies policy NNS cord-010092-uftc8inx 3606 30 for for IN cord-010092-uftc8inx 3606 31 blood blood NN cord-010092-uftc8inx 3606 32 , , , cord-010092-uftc8inx 3606 33 plasma plasma NN cord-010092-uftc8inx 3606 34 , , , cord-010092-uftc8inx 3606 35 tissues tissue NNS cord-010092-uftc8inx 3606 36 , , , cord-010092-uftc8inx 3606 37 assisted assist VBN cord-010092-uftc8inx 3606 38 reproductive reproductive JJ cord-010092-uftc8inx 3606 39 technology technology NN cord-010092-uftc8inx 3606 40 ( ( -LRB- cord-010092-uftc8inx 3606 41 ART art NN cord-010092-uftc8inx 3606 42 ) ) -RRB- cord-010092-uftc8inx 3606 43 and and CC cord-010092-uftc8inx 3606 44 stem stem NN cord-010092-uftc8inx 3606 45 cells cell NNS cord-010092-uftc8inx 3606 46 ( ( -LRB- cord-010092-uftc8inx 3606 47 together together RB cord-010092-uftc8inx 3606 48 SoHO SoHO NNP cord-010092-uftc8inx 3606 49 ) ) -RRB- cord-010092-uftc8inx 3606 50 . . . cord-010092-uftc8inx 3607 1 Donor donor NN cord-010092-uftc8inx 3607 2 selection selection NN cord-010092-uftc8inx 3607 3 criteria criterion NNS cord-010092-uftc8inx 3607 4 ( ( -LRB- cord-010092-uftc8inx 3607 5 DSC DSC NNP cord-010092-uftc8inx 3607 6 ) ) -RRB- cord-010092-uftc8inx 3607 7 in in IN cord-010092-uftc8inx 3607 8 Europe Europe NNP cord-010092-uftc8inx 3607 9 are be VBP cord-010092-uftc8inx 3607 10 based base VBN cord-010092-uftc8inx 3607 11 on on IN cord-010092-uftc8inx 3607 12 EU EU NNP cord-010092-uftc8inx 3607 13 - - HYPH cord-010092-uftc8inx 3607 14 directives directive NNS cord-010092-uftc8inx 3607 15 , , , cord-010092-uftc8inx 3607 16 guidelines guideline NNS cord-010092-uftc8inx 3607 17 and and CC cord-010092-uftc8inx 3607 18 countries country NNS cord-010092-uftc8inx 3607 19 ' ' POS cord-010092-uftc8inx 3607 20 own own JJ cord-010092-uftc8inx 3607 21 additional additional JJ cord-010092-uftc8inx 3607 22 criteria criterion NNS cord-010092-uftc8inx 3607 23 . . . cord-010092-uftc8inx 3608 1 Literature literature NN cord-010092-uftc8inx 3608 2 shows show VBZ cord-010092-uftc8inx 3608 3 that that IN cord-010092-uftc8inx 3608 4 particular particular JJ cord-010092-uftc8inx 3608 5 criteria criterion NNS cord-010092-uftc8inx 3608 6 are be VBP cord-010092-uftc8inx 3608 7 outdated outdated JJ cord-010092-uftc8inx 3608 8 or or CC cord-010092-uftc8inx 3608 9 not not RB cord-010092-uftc8inx 3608 10 risk risk NN cord-010092-uftc8inx 3608 11 - - HYPH cord-010092-uftc8inx 3608 12 based base VBN cord-010092-uftc8inx 3608 13 , , , cord-010092-uftc8inx 3608 14 often often RB cord-010092-uftc8inx 3608 15 leading lead VBG cord-010092-uftc8inx 3608 16 to to IN cord-010092-uftc8inx 3608 17 unnecessary unnecessary JJ cord-010092-uftc8inx 3608 18 donor donor NN cord-010092-uftc8inx 3608 19 deferral deferral NN cord-010092-uftc8inx 3608 20 or or CC cord-010092-uftc8inx 3608 21 an an DT cord-010092-uftc8inx 3608 22 underestimation underestimation NN cord-010092-uftc8inx 3608 23 of of IN cord-010092-uftc8inx 3608 24 risks risk NNS cord-010092-uftc8inx 3608 25 for for IN cord-010092-uftc8inx 3608 26 donors donor NNS cord-010092-uftc8inx 3608 27 . . . cord-010092-uftc8inx 3609 1 Aims aim VBZ cord-010092-uftc8inx 3609 2 : : : cord-010092-uftc8inx 3610 1 To to IN cord-010092-uftc8inx 3610 2 1 1 LS cord-010092-uftc8inx 3610 3 ) ) -RRB- cord-010092-uftc8inx 3610 4 provide provide VB cord-010092-uftc8inx 3610 5 a a DT cord-010092-uftc8inx 3610 6 comprehensive comprehensive JJ cord-010092-uftc8inx 3610 7 inventory inventory NN cord-010092-uftc8inx 3610 8 of of IN cord-010092-uftc8inx 3610 9 current current JJ cord-010092-uftc8inx 3610 10 systems system NNS cord-010092-uftc8inx 3610 11 for for IN cord-010092-uftc8inx 3610 12 selection selection NN cord-010092-uftc8inx 3610 13 and and CC cord-010092-uftc8inx 3610 14 protection protection NN cord-010092-uftc8inx 3610 15 of of IN cord-010092-uftc8inx 3610 16 donors donor NNS cord-010092-uftc8inx 3610 17 and and CC cord-010092-uftc8inx 3610 18 donations donation NNS cord-010092-uftc8inx 3610 19 , , , cord-010092-uftc8inx 3610 20 2 2 CD cord-010092-uftc8inx 3610 21 ) ) -RRB- cord-010092-uftc8inx 3611 1 critically critically RB cord-010092-uftc8inx 3611 2 review review VB cord-010092-uftc8inx 3611 3 them -PRON- PRP cord-010092-uftc8inx 3611 4 and and CC cord-010092-uftc8inx 3611 5 3 3 LS cord-010092-uftc8inx 3611 6 ) ) -RRB- cord-010092-uftc8inx 3611 7 recommend recommend VB cord-010092-uftc8inx 3611 8 an an DT cord-010092-uftc8inx 3611 9 over over RB cord-010092-uftc8inx 3611 10 - - HYPH cord-010092-uftc8inx 3611 11 arching arch VBG cord-010092-uftc8inx 3611 12 Donor Donor NNP cord-010092-uftc8inx 3611 13 Health Health NNP cord-010092-uftc8inx 3611 14 Questionnaire Questionnaire NNP cord-010092-uftc8inx 3611 15 ( ( -LRB- cord-010092-uftc8inx 3611 16 DHQ DHQ NNP cord-010092-uftc8inx 3611 17 ) ) -RRB- cord-010092-uftc8inx 3611 18 including include VBG cord-010092-uftc8inx 3611 19 all all DT cord-010092-uftc8inx 3611 20 necessary necessary JJ cord-010092-uftc8inx 3611 21 criteria criterion NNS cord-010092-uftc8inx 3611 22 currently currently RB cord-010092-uftc8inx 3611 23 used use VBN cord-010092-uftc8inx 3611 24 by by IN cord-010092-uftc8inx 3611 25 different different JJ cord-010092-uftc8inx 3611 26 EU EU NNP cord-010092-uftc8inx 3611 27 - - HYPH cord-010092-uftc8inx 3611 28 Member Member NNP cord-010092-uftc8inx 3611 29 states state NNS cord-010092-uftc8inx 3611 30 ( ( -LRB- cord-010092-uftc8inx 3611 31 EU EU NNP cord-010092-uftc8inx 3611 32 - - HYPH cord-010092-uftc8inx 3611 33 MS MS NNP cord-010092-uftc8inx 3611 34 ) ) -RRB- cord-010092-uftc8inx 3611 35 . . . cord-010092-uftc8inx 3612 1 Methods method NNS cord-010092-uftc8inx 3612 2 : : : cord-010092-uftc8inx 3612 3 In in IN cord-010092-uftc8inx 3612 4 - - HYPH cord-010092-uftc8inx 3612 5 depth depth NN cord-010092-uftc8inx 3612 6 semi semi JJ cord-010092-uftc8inx 3612 7 - - JJ cord-010092-uftc8inx 3612 8 structured structured JJ cord-010092-uftc8inx 3612 9 interviews interview NNS cord-010092-uftc8inx 3612 10 with with IN cord-010092-uftc8inx 3612 11 key key JJ cord-010092-uftc8inx 3612 12 stakeholders stakeholder NNS cord-010092-uftc8inx 3612 13 in in IN cord-010092-uftc8inx 3612 14 blood blood NN cord-010092-uftc8inx 3612 15 collection collection NN cord-010092-uftc8inx 3612 16 were be VBD cord-010092-uftc8inx 3612 17 conducted conduct VBN cord-010092-uftc8inx 3612 18 to to TO cord-010092-uftc8inx 3612 19 identify identify VB cord-010092-uftc8inx 3612 20 main main JJ cord-010092-uftc8inx 3612 21 topics topic NNS cord-010092-uftc8inx 3612 22 for for IN cord-010092-uftc8inx 3612 23 improvement improvement NN cord-010092-uftc8inx 3612 24 in in IN cord-010092-uftc8inx 3612 25 the the DT cord-010092-uftc8inx 3612 26 current current JJ cord-010092-uftc8inx 3612 27 DSC DSC NNP cord-010092-uftc8inx 3612 28 . . . cord-010092-uftc8inx 3613 1 These these DT cord-010092-uftc8inx 3613 2 formed form VBD cord-010092-uftc8inx 3613 3 the the DT cord-010092-uftc8inx 3613 4 basis basis NN cord-010092-uftc8inx 3613 5 for for IN cord-010092-uftc8inx 3613 6 a a DT cord-010092-uftc8inx 3613 7 survey survey NN cord-010092-uftc8inx 3613 8 sent send VBN cord-010092-uftc8inx 3613 9 to to IN cord-010092-uftc8inx 3613 10 professionals professional NNS cord-010092-uftc8inx 3613 11 from from IN cord-010092-uftc8inx 3613 12 collection collection NN cord-010092-uftc8inx 3613 13 institutions institution NNS cord-010092-uftc8inx 3613 14 of of IN cord-010092-uftc8inx 3613 15 all all DT cord-010092-uftc8inx 3613 16 SoHO SoHO NNP cord-010092-uftc8inx 3613 17 to to TO cord-010092-uftc8inx 3613 18 get get VB cord-010092-uftc8inx 3613 19 feedback feedback NN cord-010092-uftc8inx 3613 20 on on IN cord-010092-uftc8inx 3613 21 current current JJ cord-010092-uftc8inx 3613 22 systems system NNS cord-010092-uftc8inx 3613 23 from from IN cord-010092-uftc8inx 3613 24 as as RB cord-010092-uftc8inx 3613 25 many many JJ cord-010092-uftc8inx 3613 26 EU EU NNP cord-010092-uftc8inx 3613 27 - - HYPH cord-010092-uftc8inx 3613 28 MS MS NNP cord-010092-uftc8inx 3613 29 organisations organisation NNS cord-010092-uftc8inx 3613 30 as as IN cord-010092-uftc8inx 3613 31 possible possible JJ cord-010092-uftc8inx 3613 32 . . . cord-010092-uftc8inx 3614 1 Questionnaires questionnaire NNS cord-010092-uftc8inx 3614 2 were be VBD cord-010092-uftc8inx 3614 3 sent send VBN cord-010092-uftc8inx 3614 4 to to IN cord-010092-uftc8inx 3614 5 a a DT cord-010092-uftc8inx 3614 6 total total NN cord-010092-uftc8inx 3614 7 of of IN cord-010092-uftc8inx 3614 8 163 163 CD cord-010092-uftc8inx 3614 9 experts expert NNS cord-010092-uftc8inx 3614 10 ( ( -LRB- cord-010092-uftc8inx 3614 11 40 40 CD cord-010092-uftc8inx 3614 12 blood blood NN cord-010092-uftc8inx 3614 13 ; ; : cord-010092-uftc8inx 3614 14 40 40 CD cord-010092-uftc8inx 3614 15 plasma plasma NN cord-010092-uftc8inx 3614 16 ; ; : cord-010092-uftc8inx 3614 17 27 27 CD cord-010092-uftc8inx 3614 18 tissues tissue NNS cord-010092-uftc8inx 3614 19 ; ; : cord-010092-uftc8inx 3614 20 47 47 CD cord-010092-uftc8inx 3614 21 stem stem NN cord-010092-uftc8inx 3614 22 cells cell NNS cord-010092-uftc8inx 3614 23 ; ; : cord-010092-uftc8inx 3614 24 9 9 CD cord-010092-uftc8inx 3614 25 ART art NN cord-010092-uftc8inx 3614 26 ) ) -RRB- cord-010092-uftc8inx 3614 27 and and CC cord-010092-uftc8inx 3614 28 39 39 CD cord-010092-uftc8inx 3614 29 ( ( -LRB- cord-010092-uftc8inx 3614 30 24 24 CD cord-010092-uftc8inx 3614 31 % % NN cord-010092-uftc8inx 3614 32 ) ) -RRB- cord-010092-uftc8inx 3615 1 completed complete VBN cord-010092-uftc8inx 3615 2 questionnaires questionnaire NNS cord-010092-uftc8inx 3615 3 were be VBD cord-010092-uftc8inx 3615 4 received receive VBN cord-010092-uftc8inx 3615 5 . . . cord-010092-uftc8inx 3616 1 Where where WRB cord-010092-uftc8inx 3616 2 information information NN cord-010092-uftc8inx 3616 3 was be VBD cord-010092-uftc8inx 3616 4 lacking lack VBG cord-010092-uftc8inx 3616 5 , , , cord-010092-uftc8inx 3616 6 additional additional JJ cord-010092-uftc8inx 3616 7 experts expert NNS cord-010092-uftc8inx 3616 8 were be VBD cord-010092-uftc8inx 3616 9 asked ask VBN cord-010092-uftc8inx 3616 10 to to TO cord-010092-uftc8inx 3616 11 recommend recommend VB cord-010092-uftc8inx 3616 12 upon upon IN cord-010092-uftc8inx 3616 13 DSC DSC NNP cord-010092-uftc8inx 3616 14 . . . cord-010092-uftc8inx 3617 1 Results result NNS cord-010092-uftc8inx 3617 2 : : : cord-010092-uftc8inx 3618 1 For for IN cord-010092-uftc8inx 3618 2 blood blood NN cord-010092-uftc8inx 3618 3 and and CC cord-010092-uftc8inx 3618 4 plasma plasma NN cord-010092-uftc8inx 3618 5 donation donation NN cord-010092-uftc8inx 3618 6 four four CD cord-010092-uftc8inx 3618 7 main main JJ cord-010092-uftc8inx 3618 8 areas area NNS cord-010092-uftc8inx 3618 9 of of IN cord-010092-uftc8inx 3618 10 concern concern NN cord-010092-uftc8inx 3618 11 in in IN cord-010092-uftc8inx 3618 12 DSC DSC NNP cord-010092-uftc8inx 3618 13 were be VBD cord-010092-uftc8inx 3618 14 identified identify VBN cord-010092-uftc8inx 3618 15 : : : cord-010092-uftc8inx 3618 16 risk risk NN cord-010092-uftc8inx 3618 17 - - HYPH cord-010092-uftc8inx 3618 18 based base VBN cord-010092-uftc8inx 3618 19 selection selection NN cord-010092-uftc8inx 3618 20 , , , cord-010092-uftc8inx 3618 21 adaptability adaptability NN cord-010092-uftc8inx 3618 22 , , , cord-010092-uftc8inx 3618 23 flexibility flexibility NN cord-010092-uftc8inx 3618 24 and and CC cord-010092-uftc8inx 3618 25 consistency consistency NN cord-010092-uftc8inx 3618 26 . . . cord-010092-uftc8inx 3619 1 The the DT cord-010092-uftc8inx 3619 2 stakeholders stakeholder NNS cord-010092-uftc8inx 3619 3 agreed agree VBD cord-010092-uftc8inx 3619 4 that that IN cord-010092-uftc8inx 3619 5 DSC DSC NNP cord-010092-uftc8inx 3619 6 are be VBP cord-010092-uftc8inx 3619 7 often often RB cord-010092-uftc8inx 3619 8 outdated outdated JJ cord-010092-uftc8inx 3619 9 and and CC cord-010092-uftc8inx 3619 10 lack lack JJ cord-010092-uftc8inx 3619 11 evidence evidence NN cord-010092-uftc8inx 3619 12 , , , cord-010092-uftc8inx 3619 13 hence hence RB cord-010092-uftc8inx 3619 14 leading lead VBG cord-010092-uftc8inx 3619 15 to to IN cord-010092-uftc8inx 3619 16 unnecessary unnecessary JJ cord-010092-uftc8inx 3619 17 deferral deferral NN cord-010092-uftc8inx 3619 18 of of IN cord-010092-uftc8inx 3619 19 donors donor NNS cord-010092-uftc8inx 3619 20 and and CC cord-010092-uftc8inx 3619 21 underestimated underestimate VBD cord-010092-uftc8inx 3619 22 risks risk NNS cord-010092-uftc8inx 3619 23 for for IN cord-010092-uftc8inx 3619 24 donors donor NNS cord-010092-uftc8inx 3619 25 . . . cord-010092-uftc8inx 3620 1 They -PRON- PRP cord-010092-uftc8inx 3620 2 suggested suggest VBD cord-010092-uftc8inx 3620 3 to to TO cord-010092-uftc8inx 3620 4 base base VB cord-010092-uftc8inx 3620 5 DSC DSC NNP cord-010092-uftc8inx 3620 6 on on IN cord-010092-uftc8inx 3620 7 group group NN cord-010092-uftc8inx 3620 8 risk risk NN cord-010092-uftc8inx 3620 9 - - HYPH cord-010092-uftc8inx 3620 10 assessment assessment NN cord-010092-uftc8inx 3620 11 ( ( -LRB- cord-010092-uftc8inx 3620 12 risk risk NN cord-010092-uftc8inx 3620 13 - - HYPH cord-010092-uftc8inx 3620 14 based base VBN cord-010092-uftc8inx 3620 15 selection selection NN cord-010092-uftc8inx 3620 16 ) ) -RRB- cord-010092-uftc8inx 3620 17 and and CC cord-010092-uftc8inx 3620 18 on on IN cord-010092-uftc8inx 3620 19 conducting conduct VBG cord-010092-uftc8inx 3620 20 more more JJR cord-010092-uftc8inx 3620 21 research research NN cord-010092-uftc8inx 3620 22 to to TO cord-010092-uftc8inx 3620 23 achieve achieve VB cord-010092-uftc8inx 3620 24 standardized standardized JJ cord-010092-uftc8inx 3620 25 risk risk NN cord-010092-uftc8inx 3620 26 perceptions perception NNS cord-010092-uftc8inx 3620 27 and and CC cord-010092-uftc8inx 3620 28 evidence evidence NN cord-010092-uftc8inx 3620 29 - - HYPH cord-010092-uftc8inx 3620 30 based base VBN cord-010092-uftc8inx 3620 31 deferrals deferral NNS cord-010092-uftc8inx 3620 32 , , , cord-010092-uftc8inx 3620 33 either either CC cord-010092-uftc8inx 3620 34 for for IN cord-010092-uftc8inx 3620 35 safety safety NN cord-010092-uftc8inx 3620 36 of of IN cord-010092-uftc8inx 3620 37 recipient recipient NN cord-010092-uftc8inx 3620 38 or or CC cord-010092-uftc8inx 3620 39 donors donor NNS cord-010092-uftc8inx 3620 40 . . . cord-010092-uftc8inx 3621 1 Criteria criterion NNS cord-010092-uftc8inx 3621 2 could could MD cord-010092-uftc8inx 3621 3 be be VB cord-010092-uftc8inx 3621 4 made make VBN cord-010092-uftc8inx 3621 5 more more RBR cord-010092-uftc8inx 3621 6 detailed detailed JJ cord-010092-uftc8inx 3621 7 to to TO cord-010092-uftc8inx 3621 8 fit fit VB cord-010092-uftc8inx 3621 9 specific specific JJ cord-010092-uftc8inx 3621 10 groups group NNS cord-010092-uftc8inx 3621 11 to to TO cord-010092-uftc8inx 3621 12 defer defer VB cord-010092-uftc8inx 3621 13 less less JJR cord-010092-uftc8inx 3621 14 donors donor NNS cord-010092-uftc8inx 3621 15 ( ( -LRB- cord-010092-uftc8inx 3621 16 adaptability adaptability NN cord-010092-uftc8inx 3621 17 ) ) -RRB- cord-010092-uftc8inx 3621 18 . . . cord-010092-uftc8inx 3622 1 Furthermore furthermore RB cord-010092-uftc8inx 3622 2 , , , cord-010092-uftc8inx 3622 3 implementing implement VBG cord-010092-uftc8inx 3622 4 criteria criterion NNS cord-010092-uftc8inx 3622 5 was be VBD cord-010092-uftc8inx 3622 6 considered consider VBN cord-010092-uftc8inx 3622 7 easy easy JJ cord-010092-uftc8inx 3622 8 , , , cord-010092-uftc8inx 3622 9 but but CC cord-010092-uftc8inx 3622 10 abolish abolish VB cord-010092-uftc8inx 3622 11 criteria criterion NNS cord-010092-uftc8inx 3622 12 when when WRB cord-010092-uftc8inx 3622 13 not not RB cord-010092-uftc8inx 3622 14 regarded regard VBN cord-010092-uftc8inx 3622 15 as as IN cord-010092-uftc8inx 3622 16 a a DT cord-010092-uftc8inx 3622 17 risk risk NN cord-010092-uftc8inx 3622 18 anymore anymore RB cord-010092-uftc8inx 3622 19 seems seem VBZ cord-010092-uftc8inx 3622 20 almost almost RB cord-010092-uftc8inx 3622 21 impossible impossible JJ cord-010092-uftc8inx 3622 22 ( ( -LRB- cord-010092-uftc8inx 3622 23 flexibility flexibility NN cord-010092-uftc8inx 3622 24 ) ) -RRB- cord-010092-uftc8inx 3622 25 . . . cord-010092-uftc8inx 3623 1 Additionally additionally RB cord-010092-uftc8inx 3623 2 , , , cord-010092-uftc8inx 3623 3 deferral deferral NN cord-010092-uftc8inx 3623 4 periods period NNS cord-010092-uftc8inx 3623 5 are be VBP cord-010092-uftc8inx 3623 6 perceived perceive VBN cord-010092-uftc8inx 3623 7 too too RB cord-010092-uftc8inx 3623 8 long long RB cord-010092-uftc8inx 3623 9 , , , cord-010092-uftc8inx 3623 10 seen see VBN cord-010092-uftc8inx 3623 11 as as IN cord-010092-uftc8inx 3623 12 both both DT cord-010092-uftc8inx 3623 13 negative negative JJ cord-010092-uftc8inx 3623 14 , , , cord-010092-uftc8inx 3623 15 i.e. i.e. FW cord-010092-uftc8inx 3623 16 jeopardizing jeopardize VBG cord-010092-uftc8inx 3623 17 donor donor NN cord-010092-uftc8inx 3623 18 return return NN cord-010092-uftc8inx 3623 19 intention intention NN cord-010092-uftc8inx 3623 20 and and CC cord-010092-uftc8inx 3623 21 positive positive JJ cord-010092-uftc8inx 3623 22 , , , cord-010092-uftc8inx 3623 23 i.e. i.e. FW cord-010092-uftc8inx 3623 24 no no DT cord-010092-uftc8inx 3623 25 risk risk NN cord-010092-uftc8inx 3623 26 for for IN cord-010092-uftc8inx 3623 27 safety safety NN cord-010092-uftc8inx 3623 28 ( ( -LRB- cord-010092-uftc8inx 3623 29 consistency consistency NN cord-010092-uftc8inx 3623 30 ) ) -RRB- cord-010092-uftc8inx 3623 31 . . . cord-010092-uftc8inx 3624 1 Changing change VBG cord-010092-uftc8inx 3624 2 legislation legislation NN cord-010092-uftc8inx 3624 3 into into IN cord-010092-uftc8inx 3624 4 guidance guidance NN cord-010092-uftc8inx 3624 5 was be VBD cord-010092-uftc8inx 3624 6 an an DT cord-010092-uftc8inx 3624 7 often often RB cord-010092-uftc8inx 3624 8 - - HYPH cord-010092-uftc8inx 3624 9 mentioned mention VBN cord-010092-uftc8inx 3624 10 suggestion suggestion NN cord-010092-uftc8inx 3624 11 to to TO cord-010092-uftc8inx 3624 12 improve improve VB cord-010092-uftc8inx 3624 13 DSC DSC NNP cord-010092-uftc8inx 3624 14 . . . cord-010092-uftc8inx 3625 1 Specific specific JJ cord-010092-uftc8inx 3625 2 feedback feedback NN cord-010092-uftc8inx 3625 3 on on IN cord-010092-uftc8inx 3625 4 plasma plasma NN cord-010092-uftc8inx 3625 5 donations donation NNS cord-010092-uftc8inx 3625 6 revealed reveal VBD cord-010092-uftc8inx 3625 7 that that IN cord-010092-uftc8inx 3625 8 many many JJ cord-010092-uftc8inx 3625 9 whole whole JJ cord-010092-uftc8inx 3625 10 blood blood NN cord-010092-uftc8inx 3625 11 topics topic NNS cord-010092-uftc8inx 3625 12 are be VBP cord-010092-uftc8inx 3625 13 not not RB cord-010092-uftc8inx 3625 14 applicable applicable JJ cord-010092-uftc8inx 3625 15 to to IN cord-010092-uftc8inx 3625 16 plasma plasma NN cord-010092-uftc8inx 3625 17 - - HYPH cord-010092-uftc8inx 3625 18 only only JJ cord-010092-uftc8inx 3625 19 donors donor NNS cord-010092-uftc8inx 3625 20 , , , cord-010092-uftc8inx 3625 21 e.g. e.g. RB cord-010092-uftc8inx 3625 22 parasite parasite NN cord-010092-uftc8inx 3625 23 infections infection NNS cord-010092-uftc8inx 3625 24 such such JJ cord-010092-uftc8inx 3625 25 as as IN cord-010092-uftc8inx 3625 26 malaria malaria NN cord-010092-uftc8inx 3625 27 ( ( -LRB- cord-010092-uftc8inx 3625 28 no no DT cord-010092-uftc8inx 3625 29 deferral deferral NN cord-010092-uftc8inx 3625 30 needed need VBN cord-010092-uftc8inx 3625 31 ) ) -RRB- cord-010092-uftc8inx 3625 32 ; ; : cord-010092-uftc8inx 3625 33 travel travel VB cord-010092-uftc8inx 3625 34 history history NN cord-010092-uftc8inx 3625 35 ( ( -LRB- cord-010092-uftc8inx 3625 36 no no DT cord-010092-uftc8inx 3625 37 deferral deferral NN cord-010092-uftc8inx 3625 38 needed need VBN cord-010092-uftc8inx 3625 39 ) ) -RRB- cord-010092-uftc8inx 3625 40 , , , cord-010092-uftc8inx 3625 41 and and CC cord-010092-uftc8inx 3625 42 recent recent JJ cord-010092-uftc8inx 3625 43 bacterial bacterial JJ cord-010092-uftc8inx 3625 44 and and CC cord-010092-uftc8inx 3625 45 viral viral JJ cord-010092-uftc8inx 3625 46 infections infection NNS cord-010092-uftc8inx 3625 47 ( ( -LRB- cord-010092-uftc8inx 3625 48 deferral deferral NN cord-010092-uftc8inx 3625 49 periods period NNS cord-010092-uftc8inx 3625 50 currently currently RB cord-010092-uftc8inx 3625 51 too too RB cord-010092-uftc8inx 3625 52 long long JJ cord-010092-uftc8inx 3625 53 ) ) -RRB- cord-010092-uftc8inx 3625 54 . . . cord-010092-uftc8inx 3626 1 A a DT cord-010092-uftc8inx 3626 2 clear clear JJ cord-010092-uftc8inx 3626 3 need need NN cord-010092-uftc8inx 3626 4 for for IN cord-010092-uftc8inx 3626 5 more more JJR cord-010092-uftc8inx 3626 6 research research NN cord-010092-uftc8inx 3626 7 on on IN cord-010092-uftc8inx 3626 8 plasma plasma NN cord-010092-uftc8inx 3626 9 collection collection NN cord-010092-uftc8inx 3626 10 - - HYPH cord-010092-uftc8inx 3626 11 related relate VBN cord-010092-uftc8inx 3626 12 issues issue NNS cord-010092-uftc8inx 3626 13 was be VBD cord-010092-uftc8inx 3626 14 identified identify VBN cord-010092-uftc8inx 3626 15 . . . cord-010092-uftc8inx 3627 1 Summary Summary NNP cord-010092-uftc8inx 3627 2 / / SYM cord-010092-uftc8inx 3627 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 3627 4 : : : cord-010092-uftc8inx 3628 1 DSC DSC NNP cord-010092-uftc8inx 3628 2 are be VBP cord-010092-uftc8inx 3628 3 perceived perceive VBN cord-010092-uftc8inx 3628 4 redundant redundant JJ cord-010092-uftc8inx 3628 5 on on IN cord-010092-uftc8inx 3628 6 a a DT cord-010092-uftc8inx 3628 7 substantial substantial JJ cord-010092-uftc8inx 3628 8 number number NN cord-010092-uftc8inx 3628 9 of of IN cord-010092-uftc8inx 3628 10 aspects aspect NNS cord-010092-uftc8inx 3628 11 by by IN cord-010092-uftc8inx 3628 12 most most JJS cord-010092-uftc8inx 3628 13 stakeholders stakeholder NNS cord-010092-uftc8inx 3628 14 . . . cord-010092-uftc8inx 3629 1 Besides besides IN cord-010092-uftc8inx 3629 2 achieving achieve VBG cord-010092-uftc8inx 3629 3 the the DT cord-010092-uftc8inx 3629 4 goal goal NN cord-010092-uftc8inx 3629 5 of of IN cord-010092-uftc8inx 3629 6 save save NN cord-010092-uftc8inx 3629 7 and and CC cord-010092-uftc8inx 3629 8 sufficient sufficient JJ cord-010092-uftc8inx 3629 9 SoHO soho NN cord-010092-uftc8inx 3629 10 for for IN cord-010092-uftc8inx 3629 11 patients patient NNS cord-010092-uftc8inx 3629 12 , , , cord-010092-uftc8inx 3629 13 many many JJ cord-010092-uftc8inx 3629 14 regulations regulation NNS cord-010092-uftc8inx 3629 15 could could MD cord-010092-uftc8inx 3629 16 be be VB cord-010092-uftc8inx 3629 17 improved improve VBN cord-010092-uftc8inx 3629 18 to to TO cord-010092-uftc8inx 3629 19 diminish diminish VB cord-010092-uftc8inx 3629 20 deferrals deferral NNS cord-010092-uftc8inx 3629 21 and and CC cord-010092-uftc8inx 3629 22 decrease decrease VB cord-010092-uftc8inx 3629 23 donor donor NN cord-010092-uftc8inx 3629 24 risks risk NNS cord-010092-uftc8inx 3629 25 . . . cord-010092-uftc8inx 3630 1 TRANSPOSE transpose VB cord-010092-uftc8inx 3630 2 will will MD cord-010092-uftc8inx 3630 3 add add VB cord-010092-uftc8inx 3630 4 to to IN cord-010092-uftc8inx 3630 5 reviewing review VBG cord-010092-uftc8inx 3630 6 , , , cord-010092-uftc8inx 3630 7 improving improve VBG cord-010092-uftc8inx 3630 8 and and CC cord-010092-uftc8inx 3630 9 harmonising harmonise VBG cord-010092-uftc8inx 3630 10 these these DT cord-010092-uftc8inx 3630 11 regulations regulation NNS cord-010092-uftc8inx 3630 12 and and CC cord-010092-uftc8inx 3630 13 criteria criterion NNS cord-010092-uftc8inx 3630 14 . . . cord-010092-uftc8inx 3631 1 Furthermore furthermore RB cord-010092-uftc8inx 3631 2 , , , cord-010092-uftc8inx 3631 3 TRANSPOSE transpose VB cord-010092-uftc8inx 3631 4 will will MD cord-010092-uftc8inx 3631 5 provide provide VB cord-010092-uftc8inx 3631 6 suggestions suggestion NNS cord-010092-uftc8inx 3631 7 to to TO cord-010092-uftc8inx 3631 8 improve improve VB cord-010092-uftc8inx 3631 9 directives directive NNS cord-010092-uftc8inx 3631 10 and and CC cord-010092-uftc8inx 3631 11 guidelines guideline NNS cord-010092-uftc8inx 3631 12 and and CC cord-010092-uftc8inx 3631 13 a a DT cord-010092-uftc8inx 3631 14 DHQ dhq NN cord-010092-uftc8inx 3631 15 , , , cord-010092-uftc8inx 3631 16 focusing focus VBG cord-010092-uftc8inx 3631 17 on on IN cord-010092-uftc8inx 3631 18 both both DT cord-010092-uftc8inx 3631 19 donor donor NN cord-010092-uftc8inx 3631 20 health health NN cord-010092-uftc8inx 3631 21 protection protection NN cord-010092-uftc8inx 3631 22 and and CC cord-010092-uftc8inx 3631 23 safety safety NN cord-010092-uftc8inx 3631 24 of of IN cord-010092-uftc8inx 3631 25 donations donation NNS cord-010092-uftc8inx 3631 26 , , , cord-010092-uftc8inx 3631 27 but but CC cord-010092-uftc8inx 3631 28 also also RB cord-010092-uftc8inx 3631 29 removing remove VBG cord-010092-uftc8inx 3631 30 deferral deferral NN cord-010092-uftc8inx 3631 31 criteria criterion NNS cord-010092-uftc8inx 3631 32 that that WDT cord-010092-uftc8inx 3631 33 are be VBP cord-010092-uftc8inx 3631 34 not not RB cord-010092-uftc8inx 3631 35 relevant relevant JJ cord-010092-uftc8inx 3631 36 ( ( -LRB- cord-010092-uftc8inx 3631 37 anymore anymore RB cord-010092-uftc8inx 3631 38 ) ) -RRB- cord-010092-uftc8inx 3631 39 , , , cord-010092-uftc8inx 3631 40 and and CC cord-010092-uftc8inx 3631 41 offer offer VB cord-010092-uftc8inx 3631 42 a a DT cord-010092-uftc8inx 3631 43 future future JJ cord-010092-uftc8inx 3631 44 research research NN cord-010092-uftc8inx 3631 45 agenda agenda NN cord-010092-uftc8inx 3631 46 to to TO cord-010092-uftc8inx 3631 47 make make VB cord-010092-uftc8inx 3631 48 DSC DSC NNP cord-010092-uftc8inx 3631 49 more more JJR cord-010092-uftc8inx 3631 50 evidence evidence NN cord-010092-uftc8inx 3631 51 - - HYPH cord-010092-uftc8inx 3631 52 based base VBN cord-010092-uftc8inx 3631 53 . . . cord-010092-uftc8inx 3632 1 Background background NN cord-010092-uftc8inx 3632 2 : : : cord-010092-uftc8inx 3632 3 TRANSPOSE transpose VB cord-010092-uftc8inx 3632 4 -TRANSfusion -transfusion NN cord-010092-uftc8inx 3632 5 and and CC cord-010092-uftc8inx 3632 6 transplantation transplantation NN cord-010092-uftc8inx 3632 7 : : : cord-010092-uftc8inx 3633 1 PrOtection PrOtection NNP cord-010092-uftc8inx 3633 2 and and CC cord-010092-uftc8inx 3633 3 SElection SElection NNP cord-010092-uftc8inx 3633 4 of of IN cord-010092-uftc8inx 3633 5 donors donor NNS cord-010092-uftc8inx 3633 6 , , , cord-010092-uftc8inx 3633 7 is be VBZ cord-010092-uftc8inx 3633 8 a a DT cord-010092-uftc8inx 3633 9 European European NNP cord-010092-uftc8inx 3633 10 Commission Commission NNP cord-010092-uftc8inx 3633 11 co co NNS cord-010092-uftc8inx 3633 12 - - JJ cord-010092-uftc8inx 3633 13 funded funded JJ cord-010092-uftc8inx 3633 14 project project NN cord-010092-uftc8inx 3633 15 with with IN cord-010092-uftc8inx 3633 16 participation participation NN cord-010092-uftc8inx 3633 17 of of IN cord-010092-uftc8inx 3633 18 24 24 CD cord-010092-uftc8inx 3633 19 stakeholders stakeholder NNS cord-010092-uftc8inx 3633 20 from from IN cord-010092-uftc8inx 3633 21 both both DT cord-010092-uftc8inx 3633 22 not not RB cord-010092-uftc8inx 3633 23 - - HYPH cord-010092-uftc8inx 3633 24 for for IN cord-010092-uftc8inx 3633 25 - - HYPH cord-010092-uftc8inx 3633 26 profit profit NN cord-010092-uftc8inx 3633 27 and and CC cord-010092-uftc8inx 3633 28 private private JJ cord-010092-uftc8inx 3633 29 blood blood NN cord-010092-uftc8inx 3633 30 collecting collect VBG cord-010092-uftc8inx 3633 31 organizations organization NNS cord-010092-uftc8inx 3633 32 as as RB cord-010092-uftc8inx 3633 33 well well RB cord-010092-uftc8inx 3633 34 as as IN cord-010092-uftc8inx 3633 35 researchers researcher NNS cord-010092-uftc8inx 3633 36 and and CC cord-010092-uftc8inx 3633 37 officials official NNS cord-010092-uftc8inx 3633 38 . . . cord-010092-uftc8inx 3634 1 The the DT cord-010092-uftc8inx 3634 2 project project NN cord-010092-uftc8inx 3634 3 aims aim VBZ cord-010092-uftc8inx 3634 4 to to TO cord-010092-uftc8inx 3634 5 create create VB cord-010092-uftc8inx 3634 6 new new JJ cord-010092-uftc8inx 3634 7 evidencebased evidencebased JJ cord-010092-uftc8inx 3634 8 donor donor NN cord-010092-uftc8inx 3634 9 selection selection NN cord-010092-uftc8inx 3634 10 criteria criterion NNS cord-010092-uftc8inx 3634 11 as as RB cord-010092-uftc8inx 3634 12 well well RB cord-010092-uftc8inx 3634 13 as as IN cord-010092-uftc8inx 3634 14 guiding guide VBG cord-010092-uftc8inx 3634 15 principles principle NNS cord-010092-uftc8inx 3634 16 for for IN cord-010092-uftc8inx 3634 17 risk risk NN cord-010092-uftc8inx 3634 18 assessment assessment NN cord-010092-uftc8inx 3634 19 of of IN cord-010092-uftc8inx 3634 20 threats threat NNS cord-010092-uftc8inx 3634 21 to to IN cord-010092-uftc8inx 3634 22 the the DT cord-010092-uftc8inx 3634 23 safety safety NN cord-010092-uftc8inx 3634 24 of of IN cord-010092-uftc8inx 3634 25 all all DT cord-010092-uftc8inx 3634 26 substances substance NNS cord-010092-uftc8inx 3634 27 of of IN cord-010092-uftc8inx 3634 28 human human JJ cord-010092-uftc8inx 3634 29 origin origin NN cord-010092-uftc8inx 3634 30 ( ( -LRB- cord-010092-uftc8inx 3634 31 SoHO SoHO NNP cord-010092-uftc8inx 3634 32 ) ) -RRB- cord-010092-uftc8inx 3634 33 except except IN cord-010092-uftc8inx 3634 34 solid solid JJ cord-010092-uftc8inx 3634 35 organs organ NNS cord-010092-uftc8inx 3634 36 . . . cord-010092-uftc8inx 3635 1 As as IN cord-010092-uftc8inx 3635 2 part part NN cord-010092-uftc8inx 3635 3 of of IN cord-010092-uftc8inx 3635 4 this this DT cord-010092-uftc8inx 3635 5 , , , cord-010092-uftc8inx 3635 6 an an DT cord-010092-uftc8inx 3635 7 inventory inventory NN cord-010092-uftc8inx 3635 8 of of IN cord-010092-uftc8inx 3635 9 current current JJ cord-010092-uftc8inx 3635 10 donation donation NN cord-010092-uftc8inx 3635 11 - - HYPH cord-010092-uftc8inx 3635 12 related relate VBN cord-010092-uftc8inx 3635 13 risks risk NNS cord-010092-uftc8inx 3635 14 was be VBD cord-010092-uftc8inx 3635 15 performed perform VBN cord-010092-uftc8inx 3635 16 , , , cord-010092-uftc8inx 3635 17 including include VBG cord-010092-uftc8inx 3635 18 an an DT cord-010092-uftc8inx 3635 19 investigation investigation NN cord-010092-uftc8inx 3635 20 of of IN cord-010092-uftc8inx 3635 21 both both DT cord-010092-uftc8inx 3635 22 type type NN cord-010092-uftc8inx 3635 23 and and CC cord-010092-uftc8inx 3635 24 number number NN cord-010092-uftc8inx 3635 25 of of IN cord-010092-uftc8inx 3635 26 adverse adverse JJ cord-010092-uftc8inx 3635 27 events event NNS cord-010092-uftc8inx 3635 28 reported report VBN cord-010092-uftc8inx 3635 29 . . . cord-010092-uftc8inx 3636 1 Aims aim VBZ cord-010092-uftc8inx 3636 2 : : : cord-010092-uftc8inx 3637 1 We -PRON- PRP cord-010092-uftc8inx 3637 2 here here RB cord-010092-uftc8inx 3637 3 aim aim VBP cord-010092-uftc8inx 3637 4 to to TO cord-010092-uftc8inx 3637 5 present present VB cord-010092-uftc8inx 3637 6 an an DT cord-010092-uftc8inx 3637 7 overview overview NN cord-010092-uftc8inx 3637 8 of of IN cord-010092-uftc8inx 3637 9 reported report VBN cord-010092-uftc8inx 3637 10 adverse adverse JJ cord-010092-uftc8inx 3637 11 events event NNS cord-010092-uftc8inx 3637 12 in in IN cord-010092-uftc8inx 3637 13 plasma plasma NN cord-010092-uftc8inx 3637 14 and and CC cord-010092-uftc8inx 3637 15 whole whole JJ cord-010092-uftc8inx 3637 16 blood blood NN cord-010092-uftc8inx 3637 17 donation donation NN cord-010092-uftc8inx 3637 18 in in IN cord-010092-uftc8inx 3637 19 Europe Europe NNP cord-010092-uftc8inx 3637 20 and and CC cord-010092-uftc8inx 3637 21 to to TO cord-010092-uftc8inx 3637 22 compare compare VB cord-010092-uftc8inx 3637 23 this this DT cord-010092-uftc8inx 3637 24 to to IN cord-010092-uftc8inx 3637 25 the the DT cord-010092-uftc8inx 3637 26 anticipated anticipate VBN cord-010092-uftc8inx 3637 27 risks risk NNS cord-010092-uftc8inx 3637 28 rated rate VBN cord-010092-uftc8inx 3637 29 by by IN cord-010092-uftc8inx 3637 30 TRANSPOSE transpose NN cord-010092-uftc8inx 3637 31 stakeholders stakeholder NNS cord-010092-uftc8inx 3637 32 . . . cord-010092-uftc8inx 3638 1 Methods method NNS cord-010092-uftc8inx 3638 2 : : : cord-010092-uftc8inx 3638 3 National national JJ cord-010092-uftc8inx 3638 4 or or CC cord-010092-uftc8inx 3638 5 local local JJ cord-010092-uftc8inx 3638 6 data datum NNS cord-010092-uftc8inx 3638 7 on on IN cord-010092-uftc8inx 3638 8 adverse adverse JJ cord-010092-uftc8inx 3638 9 reactions reaction NNS cord-010092-uftc8inx 3638 10 from from IN cord-010092-uftc8inx 3638 11 the the DT cord-010092-uftc8inx 3638 12 years year NNS cord-010092-uftc8inx 3638 13 2014 2014 CD cord-010092-uftc8inx 3638 14 - - SYM cord-010092-uftc8inx 3638 15 2017 2017 CD cord-010092-uftc8inx 3638 16 , , , cord-010092-uftc8inx 3638 17 both both CC cord-010092-uftc8inx 3638 18 serious serious JJ cord-010092-uftc8inx 3638 19 and and CC cord-010092-uftc8inx 3638 20 mild mild JJ cord-010092-uftc8inx 3638 21 , , , cord-010092-uftc8inx 3638 22 in in IN cord-010092-uftc8inx 3638 23 whole whole JJ cord-010092-uftc8inx 3638 24 blood blood NN cord-010092-uftc8inx 3638 25 and and CC cord-010092-uftc8inx 3638 26 plasma plasma NN cord-010092-uftc8inx 3638 27 donors donor NNS cord-010092-uftc8inx 3638 28 was be VBD cord-010092-uftc8inx 3638 29 collected collect VBN cord-010092-uftc8inx 3638 30 from from IN cord-010092-uftc8inx 3638 31 the the DT cord-010092-uftc8inx 3638 32 relevant relevant JJ cord-010092-uftc8inx 3638 33 stakeholders stakeholder NNS cord-010092-uftc8inx 3638 34 ( ( -LRB- cord-010092-uftc8inx 3638 35 eighteen eighteen CD cord-010092-uftc8inx 3638 36 and and CC cord-010092-uftc8inx 3638 37 nineteen nineteen CD cord-010092-uftc8inx 3638 38 respectively respectively RB cord-010092-uftc8inx 3638 39 ) ) -RRB- cord-010092-uftc8inx 3638 40 . . . cord-010092-uftc8inx 3639 1 Stakeholders stakeholder NNS cord-010092-uftc8inx 3639 2 were be VBD cord-010092-uftc8inx 3639 3 also also RB cord-010092-uftc8inx 3639 4 asked ask VBN cord-010092-uftc8inx 3639 5 to to TO cord-010092-uftc8inx 3639 6 grade grade VB cord-010092-uftc8inx 3639 7 the the DT cord-010092-uftc8inx 3639 8 most most RBS cord-010092-uftc8inx 3639 9 important important JJ cord-010092-uftc8inx 3639 10 anticipated anticipate VBN cord-010092-uftc8inx 3639 11 donor donor NN cord-010092-uftc8inx 3639 12 risks risk NNS cord-010092-uftc8inx 3639 13 according accord VBG cord-010092-uftc8inx 3639 14 to to IN cord-010092-uftc8inx 3639 15 severity severity NN cord-010092-uftc8inx 3639 16 , , , cord-010092-uftc8inx 3639 17 level level NN cord-010092-uftc8inx 3639 18 of of IN cord-010092-uftc8inx 3639 19 evidence evidence NN cord-010092-uftc8inx 3639 20 and and CC cord-010092-uftc8inx 3639 21 prevalence prevalence NN cord-010092-uftc8inx 3639 22 . . . cord-010092-uftc8inx 3640 1 We -PRON- PRP cord-010092-uftc8inx 3640 2 then then RB cord-010092-uftc8inx 3640 3 compared compare VBD cord-010092-uftc8inx 3640 4 the the DT cord-010092-uftc8inx 3640 5 relevant relevant JJ cord-010092-uftc8inx 3640 6 risk risk NN cord-010092-uftc8inx 3640 7 categories category NNS cord-010092-uftc8inx 3640 8 as as IN cord-010092-uftc8inx 3640 9 evaluated evaluate VBN cord-010092-uftc8inx 3640 10 by by IN cord-010092-uftc8inx 3640 11 the the DT cord-010092-uftc8inx 3640 12 stakeholders stakeholder NNS cord-010092-uftc8inx 3640 13 with with IN cord-010092-uftc8inx 3640 14 the the DT cord-010092-uftc8inx 3640 15 categories category NNS cord-010092-uftc8inx 3640 16 of of IN cord-010092-uftc8inx 3640 17 the the DT cord-010092-uftc8inx 3640 18 provided provide VBN cord-010092-uftc8inx 3640 19 data datum NNS cord-010092-uftc8inx 3640 20 , , , cord-010092-uftc8inx 3640 21 as as RB cord-010092-uftc8inx 3640 22 well well RB cord-010092-uftc8inx 3640 23 as as IN cord-010092-uftc8inx 3640 24 the the DT cord-010092-uftc8inx 3640 25 heterogeneity heterogeneity NN cord-010092-uftc8inx 3640 26 of of IN cord-010092-uftc8inx 3640 27 category category NN cord-010092-uftc8inx 3640 28 numbers number NNS cord-010092-uftc8inx 3640 29 . . . cord-010092-uftc8inx 3641 1 Results result NNS cord-010092-uftc8inx 3641 2 : : : cord-010092-uftc8inx 3642 1 Thirteen thirteen CD cord-010092-uftc8inx 3642 2 stakeholders stakeholder NNS cord-010092-uftc8inx 3642 3 provided provide VBD cord-010092-uftc8inx 3642 4 data datum NNS cord-010092-uftc8inx 3642 5 on on IN cord-010092-uftc8inx 3642 6 adverse adverse JJ cord-010092-uftc8inx 3642 7 events event NNS cord-010092-uftc8inx 3642 8 during during IN cord-010092-uftc8inx 3642 9 whole whole JJ cord-010092-uftc8inx 3642 10 blood blood NN cord-010092-uftc8inx 3642 11 donation donation NN cord-010092-uftc8inx 3642 12 in in IN cord-010092-uftc8inx 3642 13 a a DT cord-010092-uftc8inx 3642 14 given give VBN cord-010092-uftc8inx 3642 15 year year NN cord-010092-uftc8inx 3642 16 , , , cord-010092-uftc8inx 3642 17 including include VBG cord-010092-uftc8inx 3642 18 in in IN cord-010092-uftc8inx 3642 19 total total JJ cord-010092-uftc8inx 3642 20 thirty thirty CD cord-010092-uftc8inx 3642 21 - - HYPH cord-010092-uftc8inx 3642 22 three three CD cord-010092-uftc8inx 3642 23 different different JJ cord-010092-uftc8inx 3642 24 categories category NNS cord-010092-uftc8inx 3642 25 of of IN cord-010092-uftc8inx 3642 26 adverse adverse JJ cord-010092-uftc8inx 3642 27 events event NNS cord-010092-uftc8inx 3642 28 , , , cord-010092-uftc8inx 3642 29 ranging range VBG cord-010092-uftc8inx 3642 30 from from IN cord-010092-uftc8inx 3642 31 only only RB cord-010092-uftc8inx 3642 32 one one CD cord-010092-uftc8inx 3642 33 unspecified unspecified JJ cord-010092-uftc8inx 3642 34 reaction reaction NN cord-010092-uftc8inx 3642 35 to to IN cord-010092-uftc8inx 3642 36 seventeen seventeen CD cord-010092-uftc8inx 3642 37 different different JJ cord-010092-uftc8inx 3642 38 categories category NNS cord-010092-uftc8inx 3642 39 , , , cord-010092-uftc8inx 3642 40 with with IN cord-010092-uftc8inx 3642 41 an an DT cord-010092-uftc8inx 3642 42 average average NN cord-010092-uftc8inx 3642 43 of of IN cord-010092-uftc8inx 3642 44 nine nine CD cord-010092-uftc8inx 3642 45 categories category NNS cord-010092-uftc8inx 3642 46 per per IN cord-010092-uftc8inx 3642 47 stakeholder stakeholder NN cord-010092-uftc8inx 3642 48 . . . cord-010092-uftc8inx 3643 1 The the DT cord-010092-uftc8inx 3643 2 most most RBS cord-010092-uftc8inx 3643 3 frequently frequently RB cord-010092-uftc8inx 3643 4 used use VBN cord-010092-uftc8inx 3643 5 categories category NNS cord-010092-uftc8inx 3643 6 were be VBD cord-010092-uftc8inx 3643 7 hematoma hematoma NN cord-010092-uftc8inx 3643 8 ( ( -LRB- cord-010092-uftc8inx 3643 9 included include VBN cord-010092-uftc8inx 3643 10 by by IN cord-010092-uftc8inx 3643 11 77 77 CD cord-010092-uftc8inx 3643 12 % % NN cord-010092-uftc8inx 3643 13 ) ) -RRB- cord-010092-uftc8inx 3643 14 , , , cord-010092-uftc8inx 3643 15 arterial arterial JJ cord-010092-uftc8inx 3643 16 puncture puncture NN cord-010092-uftc8inx 3643 17 ( ( -LRB- cord-010092-uftc8inx 3643 18 77 77 CD cord-010092-uftc8inx 3643 19 % % NN cord-010092-uftc8inx 3643 20 ) ) -RRB- cord-010092-uftc8inx 3643 21 and and CC cord-010092-uftc8inx 3643 22 nerve nerve NN cord-010092-uftc8inx 3643 23 damage damage NN cord-010092-uftc8inx 3643 24 ( ( -LRB- cord-010092-uftc8inx 3643 25 54 54 CD cord-010092-uftc8inx 3643 26 % % NN cord-010092-uftc8inx 3643 27 ) ) -RRB- cord-010092-uftc8inx 3643 28 . . . cord-010092-uftc8inx 3644 1 Vasovagal vasovagal JJ cord-010092-uftc8inx 3644 2 reactions reaction NNS cord-010092-uftc8inx 3644 3 were be VBD cord-010092-uftc8inx 3644 4 also also RB cord-010092-uftc8inx 3644 5 frequently frequently RB cord-010092-uftc8inx 3644 6 included include VBN cord-010092-uftc8inx 3644 7 ( ( -LRB- cord-010092-uftc8inx 3644 8 75 75 CD cord-010092-uftc8inx 3644 9 % % NN cord-010092-uftc8inx 3644 10 ) ) -RRB- cord-010092-uftc8inx 3644 11 ; ; : cord-010092-uftc8inx 3644 12 however however RB cord-010092-uftc8inx 3644 13 , , , cord-010092-uftc8inx 3644 14 this this DT cord-010092-uftc8inx 3644 15 was be VBD cord-010092-uftc8inx 3644 16 being be VBG cord-010092-uftc8inx 3644 17 done do VBN cord-010092-uftc8inx 3644 18 variably variably RB cord-010092-uftc8inx 3644 19 as as IN cord-010092-uftc8inx 3644 20 vasovagal vasovagal JJ cord-010092-uftc8inx 3644 21 reactions reaction NNS cord-010092-uftc8inx 3644 22 unspecified unspecified JJ cord-010092-uftc8inx 3644 23 , , , cord-010092-uftc8inx 3644 24 and and CC cord-010092-uftc8inx 3644 25 acute acute JJ cord-010092-uftc8inx 3644 26 and/or and/or CC cord-010092-uftc8inx 3644 27 delayed delayed JJ cord-010092-uftc8inx 3644 28 vasovagal vasovagal JJ cord-010092-uftc8inx 3644 29 reactions reaction NNS cord-010092-uftc8inx 3644 30 . . . cord-010092-uftc8inx 3645 1 Only only RB cord-010092-uftc8inx 3645 2 one one CD cord-010092-uftc8inx 3645 3 stakeholder stakeholder NN cord-010092-uftc8inx 3645 4 reported report VBD cord-010092-uftc8inx 3645 5 iron iron NN cord-010092-uftc8inx 3645 6 deficiency deficiency NN cord-010092-uftc8inx 3645 7 . . . cord-010092-uftc8inx 3646 1 For for IN cord-010092-uftc8inx 3646 2 plasma plasma NN cord-010092-uftc8inx 3646 3 donation donation NN cord-010092-uftc8inx 3646 4 , , , cord-010092-uftc8inx 3646 5 seven seven CD cord-010092-uftc8inx 3646 6 stakeholders stakeholder NNS cord-010092-uftc8inx 3646 7 provided provide VBD cord-010092-uftc8inx 3646 8 data datum NNS cord-010092-uftc8inx 3646 9 on on IN cord-010092-uftc8inx 3646 10 adverse adverse JJ cord-010092-uftc8inx 3646 11 events event NNS cord-010092-uftc8inx 3646 12 . . . cord-010092-uftc8inx 3647 1 A a DT cord-010092-uftc8inx 3647 2 total total NN cord-010092-uftc8inx 3647 3 of of IN cord-010092-uftc8inx 3647 4 twenty twenty CD cord-010092-uftc8inx 3647 5 - - HYPH cord-010092-uftc8inx 3647 6 seven seven CD cord-010092-uftc8inx 3647 7 different different JJ cord-010092-uftc8inx 3647 8 categories category NNS cord-010092-uftc8inx 3647 9 were be VBD cord-010092-uftc8inx 3647 10 reported report VBN cord-010092-uftc8inx 3647 11 , , , cord-010092-uftc8inx 3647 12 ranging range VBG cord-010092-uftc8inx 3647 13 from from IN cord-010092-uftc8inx 3647 14 one one CD cord-010092-uftc8inx 3647 15 to to IN cord-010092-uftc8inx 3647 16 seventeen seventeen CD cord-010092-uftc8inx 3647 17 per per IN cord-010092-uftc8inx 3647 18 stakeholder stakeholder NN cord-010092-uftc8inx 3647 19 , , , cord-010092-uftc8inx 3647 20 with with IN cord-010092-uftc8inx 3647 21 an an DT cord-010092-uftc8inx 3647 22 average average NN cord-010092-uftc8inx 3647 23 of of IN cord-010092-uftc8inx 3647 24 nine nine CD cord-010092-uftc8inx 3647 25 . . . cord-010092-uftc8inx 3648 1 The the DT cord-010092-uftc8inx 3648 2 most most RBS cord-010092-uftc8inx 3648 3 frequently frequently RB cord-010092-uftc8inx 3648 4 reported report VBD cord-010092-uftc8inx 3648 5 adverse adverse JJ cord-010092-uftc8inx 3648 6 events event NNS cord-010092-uftc8inx 3648 7 were be VBD cord-010092-uftc8inx 3648 8 hematoma hematoma NN cord-010092-uftc8inx 3648 9 ( ( -LRB- cord-010092-uftc8inx 3648 10 86 86 CD cord-010092-uftc8inx 3648 11 % % NN cord-010092-uftc8inx 3648 12 ) ) -RRB- cord-010092-uftc8inx 3648 13 , , , cord-010092-uftc8inx 3648 14 citrate citrate NN cord-010092-uftc8inx 3648 15 reactions reaction NNS cord-010092-uftc8inx 3648 16 ( ( -LRB- cord-010092-uftc8inx 3648 17 86 86 CD cord-010092-uftc8inx 3648 18 % % NN cord-010092-uftc8inx 3648 19 ) ) -RRB- cord-010092-uftc8inx 3648 20 and and CC cord-010092-uftc8inx 3648 21 arm arm NN cord-010092-uftc8inx 3648 22 pains pain NNS cord-010092-uftc8inx 3648 23 and and CC cord-010092-uftc8inx 3648 24 nerve nerve NN cord-010092-uftc8inx 3648 25 damage damage NN cord-010092-uftc8inx 3648 26 ( ( -LRB- cord-010092-uftc8inx 3648 27 both both DT cord-010092-uftc8inx 3648 28 57 57 CD cord-010092-uftc8inx 3648 29 % % NN cord-010092-uftc8inx 3648 30 , , , cord-010092-uftc8inx 3648 31 respectively respectively RB cord-010092-uftc8inx 3648 32 ) ) -RRB- cord-010092-uftc8inx 3648 33 . . . cord-010092-uftc8inx 3649 1 Anticipated anticipate VBN cord-010092-uftc8inx 3649 2 risks risk NNS cord-010092-uftc8inx 3649 3 in in IN cord-010092-uftc8inx 3649 4 blood blood NN cord-010092-uftc8inx 3649 5 donation donation NN cord-010092-uftc8inx 3649 6 were be VBD cord-010092-uftc8inx 3649 7 rated rate VBN cord-010092-uftc8inx 3649 8 by by IN cord-010092-uftc8inx 3649 9 nine nine CD cord-010092-uftc8inx 3649 10 stakeholders stakeholder NNS cord-010092-uftc8inx 3649 11 rating rate VBG cord-010092-uftc8inx 3649 12 iron iron NN cord-010092-uftc8inx 3649 13 deficiency deficiency NN cord-010092-uftc8inx 3649 14 , , , cord-010092-uftc8inx 3649 15 vasovagal vasovagal NN cord-010092-uftc8inx 3649 16 reactions reaction NNS cord-010092-uftc8inx 3649 17 and and CC cord-010092-uftc8inx 3649 18 hematomas hematoma NNS cord-010092-uftc8inx 3649 19 the the DT cord-010092-uftc8inx 3649 20 greatest great JJS cord-010092-uftc8inx 3649 21 risks risk NNS cord-010092-uftc8inx 3649 22 to to IN cord-010092-uftc8inx 3649 23 donors donor NNS cord-010092-uftc8inx 3649 24 . . . cord-010092-uftc8inx 3650 1 For for IN cord-010092-uftc8inx 3650 2 plasmapheresis plasmapheresis NN cord-010092-uftc8inx 3650 3 , , , cord-010092-uftc8inx 3650 4 six six CD cord-010092-uftc8inx 3650 5 stakeholders stakeholder NNS cord-010092-uftc8inx 3650 6 rated rate VBD cord-010092-uftc8inx 3650 7 vasovagal vasovagal JJ cord-010092-uftc8inx 3650 8 reactions reaction NNS cord-010092-uftc8inx 3650 9 , , , cord-010092-uftc8inx 3650 10 hematomas hematoma NNS cord-010092-uftc8inx 3650 11 and and CC cord-010092-uftc8inx 3650 12 citrate citrate NN cord-010092-uftc8inx 3650 13 reactions reaction NNS cord-010092-uftc8inx 3650 14 as as IN cord-010092-uftc8inx 3650 15 highest high JJS cord-010092-uftc8inx 3650 16 risk risk NN cord-010092-uftc8inx 3650 17 . . . cord-010092-uftc8inx 3651 1 Summary Summary NNP cord-010092-uftc8inx 3651 2 / / SYM cord-010092-uftc8inx 3651 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 3651 4 : : : cord-010092-uftc8inx 3652 1 As as IN cord-010092-uftc8inx 3652 2 shown show VBN cord-010092-uftc8inx 3652 3 , , , cord-010092-uftc8inx 3652 4 categories category NNS cord-010092-uftc8inx 3652 5 used use VBN cord-010092-uftc8inx 3652 6 to to TO cord-010092-uftc8inx 3652 7 describe describe VB cord-010092-uftc8inx 3652 8 adverse adverse JJ cord-010092-uftc8inx 3652 9 events event NNS cord-010092-uftc8inx 3652 10 in in IN cord-010092-uftc8inx 3652 11 blood blood NN cord-010092-uftc8inx 3652 12 donation donation NN cord-010092-uftc8inx 3652 13 vary vary VBP cord-010092-uftc8inx 3652 14 tremendously tremendously RB cord-010092-uftc8inx 3652 15 across across IN cord-010092-uftc8inx 3652 16 Europe Europe NNP cord-010092-uftc8inx 3652 17 , , , cord-010092-uftc8inx 3652 18 with with IN cord-010092-uftc8inx 3652 19 some some DT cord-010092-uftc8inx 3652 20 countries country NNS cord-010092-uftc8inx 3652 21 only only RB cord-010092-uftc8inx 3652 22 being be VBG cord-010092-uftc8inx 3652 23 able able JJ cord-010092-uftc8inx 3652 24 to to TO cord-010092-uftc8inx 3652 25 provide provide VB cord-010092-uftc8inx 3652 26 total total JJ cord-010092-uftc8inx 3652 27 numbers number NNS cord-010092-uftc8inx 3652 28 of of IN cord-010092-uftc8inx 3652 29 adverse adverse JJ cord-010092-uftc8inx 3652 30 events event NNS cord-010092-uftc8inx 3652 31 without without IN cord-010092-uftc8inx 3652 32 further further JJ cord-010092-uftc8inx 3652 33 specification specification NN cord-010092-uftc8inx 3652 34 . . . cord-010092-uftc8inx 3653 1 Furthermore furthermore RB cord-010092-uftc8inx 3653 2 , , , cord-010092-uftc8inx 3653 3 there there EX cord-010092-uftc8inx 3653 4 is be VBZ cord-010092-uftc8inx 3653 5 a a DT cord-010092-uftc8inx 3653 6 gap gap NN cord-010092-uftc8inx 3653 7 between between IN cord-010092-uftc8inx 3653 8 perceived perceive VBN cord-010092-uftc8inx 3653 9 high high JJ cord-010092-uftc8inx 3653 10 donor donor NN cord-010092-uftc8inx 3653 11 risks risk NNS cord-010092-uftc8inx 3653 12 and and CC cord-010092-uftc8inx 3653 13 reported report VBD cord-010092-uftc8inx 3653 14 adverse adverse JJ cord-010092-uftc8inx 3653 15 reaction reaction NN cord-010092-uftc8inx 3653 16 categories category NNS cord-010092-uftc8inx 3653 17 in in IN cord-010092-uftc8inx 3653 18 donor donor NN cord-010092-uftc8inx 3653 19 vigilance vigilance NN cord-010092-uftc8inx 3653 20 for for IN cord-010092-uftc8inx 3653 21 whole whole JJ cord-010092-uftc8inx 3653 22 blood blood NN cord-010092-uftc8inx 3653 23 , , , cord-010092-uftc8inx 3653 24 as as IN cord-010092-uftc8inx 3653 25 reports report NNS cord-010092-uftc8inx 3653 26 on on IN cord-010092-uftc8inx 3653 27 iron iron NN cord-010092-uftc8inx 3653 28 deficiency deficiency NN cord-010092-uftc8inx 3653 29 are be VBP cord-010092-uftc8inx 3653 30 virtually virtually RB cord-010092-uftc8inx 3653 31 absent absent JJ cord-010092-uftc8inx 3653 32 despite despite IN cord-010092-uftc8inx 3653 33 being be VBG cord-010092-uftc8inx 3653 34 considered consider VBN cord-010092-uftc8inx 3653 35 the the DT cord-010092-uftc8inx 3653 36 most most RBS cord-010092-uftc8inx 3653 37 significant significant JJ cord-010092-uftc8inx 3653 38 risk risk NN cord-010092-uftc8inx 3653 39 . . . cord-010092-uftc8inx 3654 1 Our -PRON- PRP$ cord-010092-uftc8inx 3654 2 findings finding NNS cord-010092-uftc8inx 3654 3 show show VBP cord-010092-uftc8inx 3654 4 the the DT cord-010092-uftc8inx 3654 5 need need NN cord-010092-uftc8inx 3654 6 for for IN cord-010092-uftc8inx 3654 7 international international JJ cord-010092-uftc8inx 3654 8 collaboration collaboration NN cord-010092-uftc8inx 3654 9 on on IN cord-010092-uftc8inx 3654 10 creating create VBG cord-010092-uftc8inx 3654 11 an an DT cord-010092-uftc8inx 3654 12 international international JJ cord-010092-uftc8inx 3654 13 standardized standardized JJ cord-010092-uftc8inx 3654 14 donor donor NN cord-010092-uftc8inx 3654 15 vigilance vigilance NN cord-010092-uftc8inx 3654 16 system system NN cord-010092-uftc8inx 3654 17 , , , cord-010092-uftc8inx 3654 18 to to TO cord-010092-uftc8inx 3654 19 gather gather VB cord-010092-uftc8inx 3654 20 more more JJR cord-010092-uftc8inx 3654 21 insight insight NN cord-010092-uftc8inx 3654 22 into into IN cord-010092-uftc8inx 3654 23 donor donor NN cord-010092-uftc8inx 3654 24 risks risk NNS cord-010092-uftc8inx 3654 25 to to TO cord-010092-uftc8inx 3654 26 protect protect VB cord-010092-uftc8inx 3654 27 the the DT cord-010092-uftc8inx 3654 28 health health NN cord-010092-uftc8inx 3654 29 of of IN cord-010092-uftc8inx 3654 30 donors donor NNS cord-010092-uftc8inx 3654 31 . . . cord-010092-uftc8inx 3655 1 Plenary Plenary NNP cord-010092-uftc8inx 3655 2 Session Session NNP cord-010092-uftc8inx 3655 3 -A -A . cord-010092-uftc8inx 3655 4 Glimpse Glimpse NNP cord-010092-uftc8inx 3655 5 of of IN cord-010092-uftc8inx 3655 6 the the DT cord-010092-uftc8inx 3655 7 Future Future NNP cord-010092-uftc8inx 3655 8 PL-03 PL-03 NNP cord-010092-uftc8inx 3655 9 - - HYPH cord-010092-uftc8inx 3655 10 01 01 CD cord-010092-uftc8inx 3655 11 Modern modern JJ cord-010092-uftc8inx 3655 12 transplantation transplantation NN cord-010092-uftc8inx 3655 13 medicine medicine NN cord-010092-uftc8inx 3655 14 has have VBZ cord-010092-uftc8inx 3655 15 made make VBN cord-010092-uftc8inx 3655 16 significant significant JJ cord-010092-uftc8inx 3655 17 progress progress NN cord-010092-uftc8inx 3655 18 within within IN cord-010092-uftc8inx 3655 19 the the DT cord-010092-uftc8inx 3655 20 last last JJ cord-010092-uftc8inx 3655 21 decades decade NNS cord-010092-uftc8inx 3655 22 due due IN cord-010092-uftc8inx 3655 23 to to IN cord-010092-uftc8inx 3655 24 a a DT cord-010092-uftc8inx 3655 25 better well RBR cord-010092-uftc8inx 3655 26 immunological immunological JJ cord-010092-uftc8inx 3655 27 understanding understanding NN cord-010092-uftc8inx 3655 28 of of IN cord-010092-uftc8inx 3655 29 rejection rejection NN cord-010092-uftc8inx 3655 30 and and CC cord-010092-uftc8inx 3655 31 advances advance VBZ cord-010092-uftc8inx 3655 32 in in IN cord-010092-uftc8inx 3655 33 immunosuppression immunosuppression NN cord-010092-uftc8inx 3655 34 . . . cord-010092-uftc8inx 3656 1 However however RB cord-010092-uftc8inx 3656 2 , , , cord-010092-uftc8inx 3656 3 the the DT cord-010092-uftc8inx 3656 4 severe severe JJ cord-010092-uftc8inx 3656 5 side side NN cord-010092-uftc8inx 3656 6 effects effect NNS cord-010092-uftc8inx 3656 7 of of IN cord-010092-uftc8inx 3656 8 long long JJ cord-010092-uftc8inx 3656 9 - - HYPH cord-010092-uftc8inx 3656 10 term term NN cord-010092-uftc8inx 3656 11 , , , cord-010092-uftc8inx 3656 12 typically typically RB cord-010092-uftc8inx 3656 13 lifelong lifelong JJ cord-010092-uftc8inx 3656 14 , , , cord-010092-uftc8inx 3656 15 immunosuppression immunosuppression NN cord-010092-uftc8inx 3656 16 and and CC cord-010092-uftc8inx 3656 17 the the DT cord-010092-uftc8inx 3656 18 shortage shortage NN cord-010092-uftc8inx 3656 19 of of IN cord-010092-uftc8inx 3656 20 donor donor NN cord-010092-uftc8inx 3656 21 organs organ NNS cord-010092-uftc8inx 3656 22 remain remain VBP cord-010092-uftc8inx 3656 23 the the DT cord-010092-uftc8inx 3656 24 major major JJ cord-010092-uftc8inx 3656 25 restrictions restriction NNS cord-010092-uftc8inx 3656 26 in in IN cord-010092-uftc8inx 3656 27 transplantation transplantation NN cord-010092-uftc8inx 3656 28 . . . cord-010092-uftc8inx 3657 1 The the DT cord-010092-uftc8inx 3657 2 idea idea NN cord-010092-uftc8inx 3657 3 behind behind IN cord-010092-uftc8inx 3657 4 all all DT cord-010092-uftc8inx 3657 5 research research NN cord-010092-uftc8inx 3657 6 to to TO cord-010092-uftc8inx 3657 7 improve improve VB cord-010092-uftc8inx 3657 8 transplant transplant NN cord-010092-uftc8inx 3657 9 outcome outcome NN cord-010092-uftc8inx 3657 10 has have VBZ cord-010092-uftc8inx 3657 11 always always RB cord-010092-uftc8inx 3657 12 been be VBN cord-010092-uftc8inx 3657 13 the the DT cord-010092-uftc8inx 3657 14 modification modification NN cord-010092-uftc8inx 3657 15 of of IN cord-010092-uftc8inx 3657 16 the the DT cord-010092-uftc8inx 3657 17 recipient recipient NN cord-010092-uftc8inx 3657 18 's 's POS cord-010092-uftc8inx 3657 19 immune immune JJ cord-010092-uftc8inx 3657 20 system system NN cord-010092-uftc8inx 3657 21 to to TO cord-010092-uftc8inx 3657 22 ideally ideally RB cord-010092-uftc8inx 3657 23 induce induce VB cord-010092-uftc8inx 3657 24 a a DT cord-010092-uftc8inx 3657 25 specific specific JJ cord-010092-uftc8inx 3657 26 tolerance tolerance NN cord-010092-uftc8inx 3657 27 towards towards IN cord-010092-uftc8inx 3657 28 the the DT cord-010092-uftc8inx 3657 29 donor donor NN cord-010092-uftc8inx 3657 30 's 's POS cord-010092-uftc8inx 3657 31 graft graft NN cord-010092-uftc8inx 3657 32 . . . cord-010092-uftc8inx 3658 1 In in IN cord-010092-uftc8inx 3658 2 fact fact NN cord-010092-uftc8inx 3658 3 , , , cord-010092-uftc8inx 3658 4 the the DT cord-010092-uftc8inx 3658 5 immunological immunological JJ cord-010092-uftc8inx 3658 6 blindness blindness NN cord-010092-uftc8inx 3658 7 of of IN cord-010092-uftc8inx 3658 8 the the DT cord-010092-uftc8inx 3658 9 recipient recipient NN cord-010092-uftc8inx 3658 10 towards towards IN cord-010092-uftc8inx 3658 11 the the DT cord-010092-uftc8inx 3658 12 donor donor NN cord-010092-uftc8inx 3658 13 's 's POS cord-010092-uftc8inx 3658 14 graft graft NN cord-010092-uftc8inx 3658 15 is be VBZ cord-010092-uftc8inx 3658 16 achieved achieve VBN cord-010092-uftc8inx 3658 17 by by IN cord-010092-uftc8inx 3658 18 a a DT cord-010092-uftc8inx 3658 19 general general JJ cord-010092-uftc8inx 3658 20 reduction reduction NN cord-010092-uftc8inx 3658 21 of of IN cord-010092-uftc8inx 3658 22 the the DT cord-010092-uftc8inx 3658 23 immune immune JJ cord-010092-uftc8inx 3658 24 system system NN cord-010092-uftc8inx 3658 25 's 's POS cord-010092-uftc8inx 3658 26 competence competence NN cord-010092-uftc8inx 3658 27 and and CC cord-010092-uftc8inx 3658 28 represents represent VBZ cord-010092-uftc8inx 3658 29 a a DT cord-010092-uftc8inx 3658 30 major major JJ cord-010092-uftc8inx 3658 31 burden burden NN cord-010092-uftc8inx 3658 32 for for IN cord-010092-uftc8inx 3658 33 transplant transplant NN cord-010092-uftc8inx 3658 34 patients patient NNS cord-010092-uftc8inx 3658 35 . . . cord-010092-uftc8inx 3659 1 The the DT cord-010092-uftc8inx 3659 2 idea idea NN cord-010092-uftc8inx 3659 3 of of IN cord-010092-uftc8inx 3659 4 invisible invisible JJ cord-010092-uftc8inx 3659 5 organs organ NNS cord-010092-uftc8inx 3659 6 is be VBZ cord-010092-uftc8inx 3659 7 an an DT cord-010092-uftc8inx 3659 8 entirely entirely RB cord-010092-uftc8inx 3659 9 different different JJ cord-010092-uftc8inx 3659 10 approach approach NN cord-010092-uftc8inx 3659 11 to to TO cord-010092-uftc8inx 3659 12 solve solve VB cord-010092-uftc8inx 3659 13 the the DT cord-010092-uftc8inx 3659 14 problem problem NN cord-010092-uftc8inx 3659 15 : : : cord-010092-uftc8inx 3659 16 instead instead RB cord-010092-uftc8inx 3659 17 of of IN cord-010092-uftc8inx 3659 18 inducing induce VBG cord-010092-uftc8inx 3659 19 an an DT cord-010092-uftc8inx 3659 20 immunological immunological JJ cord-010092-uftc8inx 3659 21 blindness blindness NN cord-010092-uftc8inx 3659 22 of of IN cord-010092-uftc8inx 3659 23 the the DT cord-010092-uftc8inx 3659 24 recipient recipient NN cord-010092-uftc8inx 3659 25 's 's POS cord-010092-uftc8inx 3659 26 immune immune JJ cord-010092-uftc8inx 3659 27 system system NN cord-010092-uftc8inx 3659 28 an an DT cord-010092-uftc8inx 3659 29 immunological immunological JJ cord-010092-uftc8inx 3659 30 invisibility invisibility NN cord-010092-uftc8inx 3659 31 of of IN cord-010092-uftc8inx 3659 32 the the DT cord-010092-uftc8inx 3659 33 donor donor NN cord-010092-uftc8inx 3659 34 's 's POS cord-010092-uftc8inx 3659 35 organ organ NN cord-010092-uftc8inx 3659 36 is be VBZ cord-010092-uftc8inx 3659 37 created create VBN cord-010092-uftc8inx 3659 38 . . . cord-010092-uftc8inx 3660 1 This this DT cord-010092-uftc8inx 3660 2 is be VBZ cord-010092-uftc8inx 3660 3 achieved achieve VBN cord-010092-uftc8inx 3660 4 by by IN cord-010092-uftc8inx 3660 5 genetically genetically RB cord-010092-uftc8inx 3660 6 engineering engineer VBG cord-010092-uftc8inx 3660 7 the the DT cord-010092-uftc8inx 3660 8 transplant transplant NN cord-010092-uftc8inx 3660 9 to to TO cord-010092-uftc8inx 3660 10 eliminate eliminate VB cord-010092-uftc8inx 3660 11 the the DT cord-010092-uftc8inx 3660 12 organ organ NN cord-010092-uftc8inx 3660 13 's 's POS cord-010092-uftc8inx 3660 14 immunogenicity immunogenicity NN cord-010092-uftc8inx 3660 15 defined define VBN cord-010092-uftc8inx 3660 16 by by IN cord-010092-uftc8inx 3660 17 the the DT cord-010092-uftc8inx 3660 18 gene gene NN cord-010092-uftc8inx 3660 19 products product NNS cord-010092-uftc8inx 3660 20 of of IN cord-010092-uftc8inx 3660 21 the the DT cord-010092-uftc8inx 3660 22 major major JJ cord-010092-uftc8inx 3660 23 histocompatibility histocompatibility NN cord-010092-uftc8inx 3660 24 complex complex NN cord-010092-uftc8inx 3660 25 ( ( -LRB- cord-010092-uftc8inx 3660 26 MHC MHC NNP cord-010092-uftc8inx 3660 27 ) ) -RRB- cord-010092-uftc8inx 3660 28 and and CC cord-010092-uftc8inx 3660 29 minor minor JJ cord-010092-uftc8inx 3660 30 histocompatibility histocompatibility NN cord-010092-uftc8inx 3660 31 antigens antigen NNS cord-010092-uftc8inx 3660 32 . . . cord-010092-uftc8inx 3661 1 In in IN cord-010092-uftc8inx 3661 2 addition addition NN cord-010092-uftc8inx 3661 3 to to IN cord-010092-uftc8inx 3661 4 manipulating manipulate VBG cord-010092-uftc8inx 3661 5 the the DT cord-010092-uftc8inx 3661 6 expression expression NN cord-010092-uftc8inx 3661 7 of of IN cord-010092-uftc8inx 3661 8 MHC MHC NNP cord-010092-uftc8inx 3661 9 genes gene NNS cord-010092-uftc8inx 3661 10 required require VBN cord-010092-uftc8inx 3661 11 for for IN cord-010092-uftc8inx 3661 12 immune immune JJ cord-010092-uftc8inx 3661 13 recognition recognition NN cord-010092-uftc8inx 3661 14 , , , cord-010092-uftc8inx 3661 15 immune immune JJ cord-010092-uftc8inx 3661 16 cloaking cloaking NN cord-010092-uftc8inx 3661 17 strategies strategy NNS cord-010092-uftc8inx 3661 18 are be VBP cord-010092-uftc8inx 3661 19 used use VBN cord-010092-uftc8inx 3661 20 to to TO cord-010092-uftc8inx 3661 21 evade evade VB cord-010092-uftc8inx 3661 22 immune immune JJ cord-010092-uftc8inx 3661 23 rejection rejection NN cord-010092-uftc8inx 3661 24 . . . cord-010092-uftc8inx 3662 1 These these DT cord-010092-uftc8inx 3662 2 approaches approach NNS cord-010092-uftc8inx 3662 3 take take VBP cord-010092-uftc8inx 3662 4 advantage advantage NN cord-010092-uftc8inx 3662 5 of of IN cord-010092-uftc8inx 3662 6 creating create VBG cord-010092-uftc8inx 3662 7 an an DT cord-010092-uftc8inx 3662 8 immunosuppressive immunosuppressive JJ cord-010092-uftc8inx 3662 9 environment environment NN cord-010092-uftc8inx 3662 10 and and CC cord-010092-uftc8inx 3662 11 expressing express VBG cord-010092-uftc8inx 3662 12 immune immune JJ cord-010092-uftc8inx 3662 13 suppressive suppressive JJ cord-010092-uftc8inx 3662 14 molecules molecule NNS cord-010092-uftc8inx 3662 15 by by IN cord-010092-uftc8inx 3662 16 immunomodulatory immunomodulatory NNP cord-010092-uftc8inx 3662 17 transgenes transgene NNS cord-010092-uftc8inx 3662 18 . . . cord-010092-uftc8inx 3663 1 MHC MHC NNP cord-010092-uftc8inx 3663 2 engineering engineering NN cord-010092-uftc8inx 3663 3 and and CC cord-010092-uftc8inx 3663 4 immune immune JJ cord-010092-uftc8inx 3663 5 cloaking cloaking NN cord-010092-uftc8inx 3663 6 in in IN cord-010092-uftc8inx 3663 7 an an DT cord-010092-uftc8inx 3663 8 entire entire JJ cord-010092-uftc8inx 3663 9 organ organ NN cord-010092-uftc8inx 3663 10 is be VBZ cord-010092-uftc8inx 3663 11 achieved achieve VBN cord-010092-uftc8inx 3663 12 during during IN cord-010092-uftc8inx 3663 13 ex ex FW cord-010092-uftc8inx 3663 14 vivo vivo NN cord-010092-uftc8inx 3663 15 perfusion perfusion NN cord-010092-uftc8inx 3663 16 by by IN cord-010092-uftc8inx 3663 17 lentiviral lentiviral JJ cord-010092-uftc8inx 3663 18 transduction transduction NN cord-010092-uftc8inx 3663 19 of of IN cord-010092-uftc8inx 3663 20 gene gene NN cord-010092-uftc8inx 3663 21 expression expression NN cord-010092-uftc8inx 3663 22 modifiers modifier NNS cord-010092-uftc8inx 3663 23 and and CC cord-010092-uftc8inx 3663 24 transgenes transgene NNS cord-010092-uftc8inx 3663 25 to to TO cord-010092-uftc8inx 3663 26 induce induce VB cord-010092-uftc8inx 3663 27 a a DT cord-010092-uftc8inx 3663 28 permanent permanent JJ cord-010092-uftc8inx 3663 29 immunological immunological JJ cord-010092-uftc8inx 3663 30 invisibility invisibility NN cord-010092-uftc8inx 3663 31 of of IN cord-010092-uftc8inx 3663 32 the the DT cord-010092-uftc8inx 3663 33 organ organ NN cord-010092-uftc8inx 3663 34 . . . cord-010092-uftc8inx 3664 1 Importantly importantly RB cord-010092-uftc8inx 3664 2 , , , cord-010092-uftc8inx 3664 3 MHC MHC NNP cord-010092-uftc8inx 3664 4 engineering engineering NN cord-010092-uftc8inx 3664 5 also also RB cord-010092-uftc8inx 3664 6 prevents prevent VBZ cord-010092-uftc8inx 3664 7 the the DT cord-010092-uftc8inx 3664 8 presentation presentation NN cord-010092-uftc8inx 3664 9 of of IN cord-010092-uftc8inx 3664 10 minor minor JJ cord-010092-uftc8inx 3664 11 histocompatibility histocompatibility NN cord-010092-uftc8inx 3664 12 antigens antigen NNS cord-010092-uftc8inx 3664 13 , , , cord-010092-uftc8inx 3664 14 which which WDT cord-010092-uftc8inx 3664 15 usually usually RB cord-010092-uftc8inx 3664 16 are be VBP cord-010092-uftc8inx 3664 17 not not RB cord-010092-uftc8inx 3664 18 possible possible JJ cord-010092-uftc8inx 3664 19 to to TO cord-010092-uftc8inx 3664 20 match match VB cord-010092-uftc8inx 3664 21 between between IN cord-010092-uftc8inx 3664 22 donor donor NN cord-010092-uftc8inx 3664 23 and and CC cord-010092-uftc8inx 3664 24 recipient recipient NN cord-010092-uftc8inx 3664 25 , , , cord-010092-uftc8inx 3664 26 but but CC cord-010092-uftc8inx 3664 27 which which WDT cord-010092-uftc8inx 3664 28 trigger trigger VBP cord-010092-uftc8inx 3664 29 potent potent JJ cord-010092-uftc8inx 3664 30 immune immune JJ cord-010092-uftc8inx 3664 31 responses response NNS cord-010092-uftc8inx 3664 32 and and CC cord-010092-uftc8inx 3664 33 graft graft NN cord-010092-uftc8inx 3664 34 rejection rejection NN cord-010092-uftc8inx 3664 35 . . . cord-010092-uftc8inx 3665 1 Eliminating eliminate VBG cord-010092-uftc8inx 3665 2 the the DT cord-010092-uftc8inx 3665 3 targets target NNS cord-010092-uftc8inx 3665 4 of of IN cord-010092-uftc8inx 3665 5 cellular cellular JJ cord-010092-uftc8inx 3665 6 and and CC cord-010092-uftc8inx 3665 7 humoral humoral JJ cord-010092-uftc8inx 3665 8 rejection rejection NN cord-010092-uftc8inx 3665 9 as as RB cord-010092-uftc8inx 3665 10 well well RB cord-010092-uftc8inx 3665 11 as as IN cord-010092-uftc8inx 3665 12 creating create VBG cord-010092-uftc8inx 3665 13 an an DT cord-010092-uftc8inx 3665 14 allograft allograft NN cord-010092-uftc8inx 3665 15 - - HYPH cord-010092-uftc8inx 3665 16 specific specific JJ cord-010092-uftc8inx 3665 17 immune immune JJ cord-010092-uftc8inx 3665 18 environment environment NN cord-010092-uftc8inx 3665 19 through through IN cord-010092-uftc8inx 3665 20 immune immune JJ cord-010092-uftc8inx 3665 21 cloaking cloaking NN cord-010092-uftc8inx 3665 22 camouflages camouflage VBZ cord-010092-uftc8inx 3665 23 the the DT cord-010092-uftc8inx 3665 24 organ organ NN cord-010092-uftc8inx 3665 25 and and CC cord-010092-uftc8inx 3665 26 equips equip VBZ cord-010092-uftc8inx 3665 27 it -PRON- PRP cord-010092-uftc8inx 3665 28 with with IN cord-010092-uftc8inx 3665 29 a a DT cord-010092-uftc8inx 3665 30 powerful powerful JJ cord-010092-uftc8inx 3665 31 set set NN cord-010092-uftc8inx 3665 32 of of IN cord-010092-uftc8inx 3665 33 defense defense NN cord-010092-uftc8inx 3665 34 weaponry weaponry NN cord-010092-uftc8inx 3665 35 . . . cord-010092-uftc8inx 3666 1 Immune immune NN cord-010092-uftc8inx 3666 2 - - HYPH cord-010092-uftc8inx 3666 3 engineering engineering NN cord-010092-uftc8inx 3666 4 of of IN cord-010092-uftc8inx 3666 5 transplants transplant NNS cord-010092-uftc8inx 3666 6 achieved achieve VBN cord-010092-uftc8inx 3666 7 during during IN cord-010092-uftc8inx 3666 8 the the DT cord-010092-uftc8inx 3666 9 inevitable inevitable JJ cord-010092-uftc8inx 3666 10 ex ex FW cord-010092-uftc8inx 3666 11 vivo vivo NN cord-010092-uftc8inx 3666 12 period period NN cord-010092-uftc8inx 3666 13 of of IN cord-010092-uftc8inx 3666 14 the the DT cord-010092-uftc8inx 3666 15 allograft allograft NN cord-010092-uftc8inx 3666 16 after after IN cord-010092-uftc8inx 3666 17 explantation explantation NN cord-010092-uftc8inx 3666 18 without without IN cord-010092-uftc8inx 3666 19 the the DT cord-010092-uftc8inx 3666 20 need need NN cord-010092-uftc8inx 3666 21 to to TO cord-010092-uftc8inx 3666 22 accept accept VB cord-010092-uftc8inx 3666 23 off off IN cord-010092-uftc8inx 3666 24 - - HYPH cord-010092-uftc8inx 3666 25 target target NN cord-010092-uftc8inx 3666 26 effects effect NNS cord-010092-uftc8inx 3666 27 allows allow VBZ cord-010092-uftc8inx 3666 28 keeping keep VBG cord-010092-uftc8inx 3666 29 the the DT cord-010092-uftc8inx 3666 30 recipient recipient NN cord-010092-uftc8inx 3666 31 's 's POS cord-010092-uftc8inx 3666 32 immune immune JJ cord-010092-uftc8inx 3666 33 system system NN cord-010092-uftc8inx 3666 34 fully fully RB cord-010092-uftc8inx 3666 35 functional functional JJ cord-010092-uftc8inx 3666 36 and and CC cord-010092-uftc8inx 3666 37 capable capable JJ cord-010092-uftc8inx 3666 38 to to TO cord-010092-uftc8inx 3666 39 combat combat VB cord-010092-uftc8inx 3666 40 infections infection NNS cord-010092-uftc8inx 3666 41 and and CC cord-010092-uftc8inx 3666 42 cancer cancer NN cord-010092-uftc8inx 3666 43 . . . cord-010092-uftc8inx 3667 1 In in IN cord-010092-uftc8inx 3667 2 pre pre JJ cord-010092-uftc8inx 3667 3 - - JJ cord-010092-uftc8inx 3667 4 clinical clinical JJ cord-010092-uftc8inx 3667 5 in in IN cord-010092-uftc8inx 3667 6 vivo vivo NN cord-010092-uftc8inx 3667 7 studies study NNS cord-010092-uftc8inx 3667 8 from from IN cord-010092-uftc8inx 3667 9 rodents rodent NNS cord-010092-uftc8inx 3667 10 to to TO cord-010092-uftc8inx 3667 11 minipigs minipigs VB cord-010092-uftc8inx 3667 12 a a DT cord-010092-uftc8inx 3667 13 clear clear JJ cord-010092-uftc8inx 3667 14 survival survival NN cord-010092-uftc8inx 3667 15 advantage advantage NN cord-010092-uftc8inx 3667 16 of of IN cord-010092-uftc8inx 3667 17 ex ex FW cord-010092-uftc8inx 3667 18 vivo vivo NN cord-010092-uftc8inx 3667 19 engineered engineer VBN cord-010092-uftc8inx 3667 20 transplants transplant NNS cord-010092-uftc8inx 3667 21 could could MD cord-010092-uftc8inx 3667 22 be be VB cord-010092-uftc8inx 3667 23 demonstrated demonstrate VBN cord-010092-uftc8inx 3667 24 . . . cord-010092-uftc8inx 3668 1 This this DT cord-010092-uftc8inx 3668 2 approach approach NN cord-010092-uftc8inx 3668 3 has have VBZ cord-010092-uftc8inx 3668 4 the the DT cord-010092-uftc8inx 3668 5 potential potential NN cord-010092-uftc8inx 3668 6 of of IN cord-010092-uftc8inx 3668 7 eliminating eliminate VBG cord-010092-uftc8inx 3668 8 the the DT cord-010092-uftc8inx 3668 9 burden burden NN cord-010092-uftc8inx 3668 10 of of IN cord-010092-uftc8inx 3668 11 organ organ NN cord-010092-uftc8inx 3668 12 rejection rejection NN cord-010092-uftc8inx 3668 13 and and CC cord-010092-uftc8inx 3668 14 immunosuppression immunosuppression NN cord-010092-uftc8inx 3668 15 , , , cord-010092-uftc8inx 3668 16 thereby thereby RB cord-010092-uftc8inx 3668 17 sustainably sustainably RB cord-010092-uftc8inx 3668 18 increasing increase VBG cord-010092-uftc8inx 3668 19 transplant transplant NN cord-010092-uftc8inx 3668 20 survival survival NN cord-010092-uftc8inx 3668 21 , , , cord-010092-uftc8inx 3668 22 organ organ NN cord-010092-uftc8inx 3668 23 availability availability NN cord-010092-uftc8inx 3668 24 and and CC cord-010092-uftc8inx 3668 25 quality quality NN cord-010092-uftc8inx 3668 26 of of IN cord-010092-uftc8inx 3668 27 life life NN cord-010092-uftc8inx 3668 28 . . . cord-010092-uftc8inx 3669 1 Gene gene NN cord-010092-uftc8inx 3669 2 editing editing NN cord-010092-uftc8inx 3669 3 for for IN cord-010092-uftc8inx 3669 4 sickle sickle NN cord-010092-uftc8inx 3669 5 cell cell NN cord-010092-uftc8inx 3669 6 disease disease NN cord-010092-uftc8inx 3669 7 : : : cord-010092-uftc8inx 3669 8 Re re NN cord-010092-uftc8inx 3669 9 - - NN cord-010092-uftc8inx 3669 10 expression expression NN cord-010092-uftc8inx 3669 11 of of IN cord-010092-uftc8inx 3669 12 the the DT cord-010092-uftc8inx 3669 13 fetal fetal JJ cord-010092-uftc8inx 3669 14 c c NN cord-010092-uftc8inx 3669 15 - - HYPH cord-010092-uftc8inx 3669 16 globin globin NN cord-010092-uftc8inx 3669 17 genes gene NNS cord-010092-uftc8inx 3669 18 ( ( -LRB- cord-010092-uftc8inx 3669 19 HBG1/2 HBG1/2 NNP cord-010092-uftc8inx 3669 20 ) ) -RRB- cord-010092-uftc8inx 3669 21 could could MD cord-010092-uftc8inx 3669 22 be be VB cord-010092-uftc8inx 3669 23 a a DT cord-010092-uftc8inx 3669 24 universal universal JJ cord-010092-uftc8inx 3669 25 strategy strategy NN cord-010092-uftc8inx 3669 26 to to TO cord-010092-uftc8inx 3669 27 ameliorate ameliorate VB cord-010092-uftc8inx 3669 28 the the DT cord-010092-uftc8inx 3669 29 severe severe JJ cord-010092-uftc8inx 3669 30 b b NN cord-010092-uftc8inx 3669 31 - - HYPH cord-010092-uftc8inx 3669 32 globin globin NN cord-010092-uftc8inx 3669 33 disorders disorder NNS cord-010092-uftc8inx 3669 34 sickle sickle VBP cord-010092-uftc8inx 3669 35 cell cell NN cord-010092-uftc8inx 3669 36 disease disease NN cord-010092-uftc8inx 3669 37 ( ( -LRB- cord-010092-uftc8inx 3669 38 SCD SCD NNP cord-010092-uftc8inx 3669 39 ) ) -RRB- cord-010092-uftc8inx 3669 40 and and CC cord-010092-uftc8inx 3669 41 b b NN cord-010092-uftc8inx 3669 42 - - HYPH cord-010092-uftc8inx 3669 43 thalassemia thalassemia NN cord-010092-uftc8inx 3669 44 by by IN cord-010092-uftc8inx 3669 45 induction induction NN cord-010092-uftc8inx 3669 46 of of IN cord-010092-uftc8inx 3669 47 fetal fetal JJ cord-010092-uftc8inx 3669 48 hemoglobin hemoglobin NN cord-010092-uftc8inx 3669 49 ( ( -LRB- cord-010092-uftc8inx 3669 50 HbF HbF NNP cord-010092-uftc8inx 3669 51 , , , cord-010092-uftc8inx 3669 52 a a DT cord-010092-uftc8inx 3669 53 2 2 CD cord-010092-uftc8inx 3669 54 c c NN cord-010092-uftc8inx 3669 55 2 2 CD cord-010092-uftc8inx 3669 56 ) ) -RRB- cord-010092-uftc8inx 3669 57 . . . cord-010092-uftc8inx 3670 1 We -PRON- PRP cord-010092-uftc8inx 3670 2 have have VBP cord-010092-uftc8inx 3670 3 previously previously RB cord-010092-uftc8inx 3670 4 identified identify VBN cord-010092-uftc8inx 3670 5 BCL11A bcl11a JJ cord-010092-uftc8inx 3670 6 erythroid erythroid NN cord-010092-uftc8inx 3670 7 enhancer enhancer NN cord-010092-uftc8inx 3670 8 sequences sequence NNS cord-010092-uftc8inx 3670 9 , , , cord-010092-uftc8inx 3670 10 marked mark VBN cord-010092-uftc8inx 3670 11 by by IN cord-010092-uftc8inx 3670 12 HbF hbf NN cord-010092-uftc8inx 3670 13 - - HYPH cord-010092-uftc8inx 3670 14 associated associate VBN cord-010092-uftc8inx 3670 15 common common JJ cord-010092-uftc8inx 3670 16 genetic genetic JJ cord-010092-uftc8inx 3670 17 variants variant NNS cord-010092-uftc8inx 3670 18 , , , cord-010092-uftc8inx 3670 19 that that WDT cord-010092-uftc8inx 3670 20 are be VBP cord-010092-uftc8inx 3670 21 required require VBN cord-010092-uftc8inx 3670 22 for for IN cord-010092-uftc8inx 3670 23 repression repression NN cord-010092-uftc8inx 3670 24 of of IN cord-010092-uftc8inx 3670 25 HbF hbf NN cord-010092-uftc8inx 3670 26 in in IN cord-010092-uftc8inx 3670 27 adult adult NN cord-010092-uftc8inx 3670 28 - - HYPH cord-010092-uftc8inx 3670 29 stage stage NN cord-010092-uftc8inx 3670 30 erythroid erythroid NN cord-010092-uftc8inx 3670 31 cells cell NNS cord-010092-uftc8inx 3670 32 but but CC cord-010092-uftc8inx 3670 33 dispensable dispensable JJ cord-010092-uftc8inx 3670 34 in in IN cord-010092-uftc8inx 3670 35 non non JJ cord-010092-uftc8inx 3670 36 - - JJ cord-010092-uftc8inx 3670 37 erythroid erythroid JJ cord-010092-uftc8inx 3670 38 cells cell NNS cord-010092-uftc8inx 3670 39 . . . cord-010092-uftc8inx 3671 1 Recently recently RB cord-010092-uftc8inx 3671 2 we -PRON- PRP cord-010092-uftc8inx 3671 3 have have VBP cord-010092-uftc8inx 3671 4 optimized optimize VBN cord-010092-uftc8inx 3671 5 conditions condition NNS cord-010092-uftc8inx 3671 6 for for IN cord-010092-uftc8inx 3671 7 selection selection NN cord-010092-uftc8inx 3671 8 - - HYPH cord-010092-uftc8inx 3671 9 free free JJ cord-010092-uftc8inx 3671 10 on on IN cord-010092-uftc8inx 3671 11 - - HYPH cord-010092-uftc8inx 3671 12 target target NN cord-010092-uftc8inx 3671 13 CRISPR CRISPR NNP cord-010092-uftc8inx 3671 14 - - HYPH cord-010092-uftc8inx 3671 15 Cas9 Cas9 NNP cord-010092-uftc8inx 3671 16 editing editing NN cord-010092-uftc8inx 3671 17 in in IN cord-010092-uftc8inx 3671 18 human human JJ cord-010092-uftc8inx 3671 19 HSCs hsc NNS cord-010092-uftc8inx 3671 20 as as IN cord-010092-uftc8inx 3671 21 a a DT cord-010092-uftc8inx 3671 22 nearly nearly RB cord-010092-uftc8inx 3671 23 complete complete JJ cord-010092-uftc8inx 3671 24 reaction reaction NN cord-010092-uftc8inx 3671 25 without without IN cord-010092-uftc8inx 3671 26 detectable detectable JJ cord-010092-uftc8inx 3671 27 genotoxicity genotoxicity NN cord-010092-uftc8inx 3671 28 or or CC cord-010092-uftc8inx 3671 29 deleterious deleterious JJ cord-010092-uftc8inx 3671 30 impact impact NN cord-010092-uftc8inx 3671 31 on on IN cord-010092-uftc8inx 3671 32 stem stem NN cord-010092-uftc8inx 3671 33 cell cell NN cord-010092-uftc8inx 3671 34 function function NN cord-010092-uftc8inx 3671 35 . . . cord-010092-uftc8inx 3672 1 We -PRON- PRP cord-010092-uftc8inx 3672 2 demonstrate demonstrate VBP cord-010092-uftc8inx 3672 3 that that IN cord-010092-uftc8inx 3672 4 Cas9 Cas9 NNP cord-010092-uftc8inx 3672 5 : : : cord-010092-uftc8inx 3672 6 sgRNA sgRNA `` cord-010092-uftc8inx 3672 7 ribonucleoprotein ribonucleoprotein NN cord-010092-uftc8inx 3672 8 ( ( -LRB- cord-010092-uftc8inx 3672 9 RNP RNP NNP cord-010092-uftc8inx 3672 10 ) ) -RRB- cord-010092-uftc8inx 3672 11 mediated mediate VBN cord-010092-uftc8inx 3672 12 cleavage cleavage NN cord-010092-uftc8inx 3672 13 at at IN cord-010092-uftc8inx 3672 14 core core NN cord-010092-uftc8inx 3672 15 sequences sequence NNS cord-010092-uftc8inx 3672 16 of of IN cord-010092-uftc8inx 3672 17 the the DT cord-010092-uftc8inx 3672 18 + + SYM cord-010092-uftc8inx 3672 19 58 58 CD cord-010092-uftc8inx 3672 20 BCL11A bcl11a NN cord-010092-uftc8inx 3672 21 erythroid erythroid NN cord-010092-uftc8inx 3672 22 enhancer enhancer NN cord-010092-uftc8inx 3672 23 results result NNS cord-010092-uftc8inx 3672 24 in in IN cord-010092-uftc8inx 3672 25 highly highly RB cord-010092-uftc8inx 3672 26 penetrant penetrant JJ cord-010092-uftc8inx 3672 27 disruption disruption NN cord-010092-uftc8inx 3672 28 of of IN cord-010092-uftc8inx 3672 29 GATA1 GATA1 NNS cord-010092-uftc8inx 3672 30 binding bind VBG cord-010092-uftc8inx 3672 31 motif motif NN cord-010092-uftc8inx 3672 32 , , , cord-010092-uftc8inx 3672 33 reduction reduction NN cord-010092-uftc8inx 3672 34 of of IN cord-010092-uftc8inx 3672 35 BCL11A bcl11a JJ cord-010092-uftc8inx 3672 36 expression expression NN cord-010092-uftc8inx 3672 37 , , , cord-010092-uftc8inx 3672 38 and and CC cord-010092-uftc8inx 3672 39 induction induction NN cord-010092-uftc8inx 3672 40 of of IN cord-010092-uftc8inx 3672 41 fetal fetal JJ cord-010092-uftc8inx 3672 42 c c NN cord-010092-uftc8inx 3672 43 - - HYPH cord-010092-uftc8inx 3672 44 globin globin NN cord-010092-uftc8inx 3672 45 . . . cord-010092-uftc8inx 3673 1 Erythroid Erythroid NNP cord-010092-uftc8inx 3673 2 progeny progeny NN cord-010092-uftc8inx 3673 3 of of IN cord-010092-uftc8inx 3673 4 edited edit VBN cord-010092-uftc8inx 3673 5 engrafting engrafting NNP cord-010092-uftc8inx 3673 6 SCD SCD NNP cord-010092-uftc8inx 3673 7 HSCs HSCs NNP cord-010092-uftc8inx 3673 8 express express VBP cord-010092-uftc8inx 3673 9 therapeutic therapeutic JJ cord-010092-uftc8inx 3673 10 levels level NNS cord-010092-uftc8inx 3673 11 of of IN cord-010092-uftc8inx 3673 12 HbF hbf NN cord-010092-uftc8inx 3673 13 and and CC cord-010092-uftc8inx 3673 14 resist resist VB cord-010092-uftc8inx 3673 15 sickling sickling NN cord-010092-uftc8inx 3673 16 , , , cord-010092-uftc8inx 3673 17 while while IN cord-010092-uftc8inx 3673 18 those those DT cord-010092-uftc8inx 3673 19 from from IN cord-010092-uftc8inx 3673 20 b b NN cord-010092-uftc8inx 3673 21 - - HYPH cord-010092-uftc8inx 3673 22 thalassemia thalassemia NN cord-010092-uftc8inx 3673 23 patients patient NNS cord-010092-uftc8inx 3673 24 show show VBP cord-010092-uftc8inx 3673 25 restored restore VBN cord-010092-uftc8inx 3673 26 globin globin NN cord-010092-uftc8inx 3673 27 chain chain NN cord-010092-uftc8inx 3673 28 balance balance NN cord-010092-uftc8inx 3673 29 . . . cord-010092-uftc8inx 3674 1 Moreover moreover RB cord-010092-uftc8inx 3674 2 we -PRON- PRP cord-010092-uftc8inx 3674 3 find find VBP cord-010092-uftc8inx 3674 4 that that IN cord-010092-uftc8inx 3674 5 HSCs hscs NN cord-010092-uftc8inx 3674 6 preferentially preferentially RB cord-010092-uftc8inx 3674 7 undergo undergo VBP cord-010092-uftc8inx 3674 8 nonhomologous nonhomologous JJ cord-010092-uftc8inx 3674 9 as as IN cord-010092-uftc8inx 3674 10 compared compare VBN cord-010092-uftc8inx 3674 11 to to IN cord-010092-uftc8inx 3674 12 microhomology microhomology NN cord-010092-uftc8inx 3674 13 mediated mediate VBN cord-010092-uftc8inx 3674 14 end end NN cord-010092-uftc8inx 3674 15 - - HYPH cord-010092-uftc8inx 3674 16 joining join VBG cord-010092-uftc8inx 3674 17 repair repair NN cord-010092-uftc8inx 3674 18 . . . cord-010092-uftc8inx 3675 1 NHEJ NHEJ NNP cord-010092-uftc8inx 3675 2 - - HYPH cord-010092-uftc8inx 3675 3 based base VBN cord-010092-uftc8inx 3675 4 BCL11A bcl11a NN cord-010092-uftc8inx 3675 5 enhancer enhancer NN cord-010092-uftc8inx 3675 6 editing editing NN cord-010092-uftc8inx 3675 7 approaching approach VBG cord-010092-uftc8inx 3675 8 complete complete JJ cord-010092-uftc8inx 3675 9 allelic allelic JJ cord-010092-uftc8inx 3675 10 disruption disruption NN cord-010092-uftc8inx 3675 11 in in IN cord-010092-uftc8inx 3675 12 HSCs HSCs NNP cord-010092-uftc8inx 3675 13 appears appear VBZ cord-010092-uftc8inx 3675 14 to to TO cord-010092-uftc8inx 3675 15 be be VB cord-010092-uftc8inx 3675 16 a a DT cord-010092-uftc8inx 3675 17 feasible feasible JJ cord-010092-uftc8inx 3675 18 therapeutic therapeutic JJ cord-010092-uftc8inx 3675 19 strategy strategy NN cord-010092-uftc8inx 3675 20 to to TO cord-010092-uftc8inx 3675 21 produce produce VB cord-010092-uftc8inx 3675 22 durable durable JJ cord-010092-uftc8inx 3675 23 HbF hbf JJ cord-010092-uftc8inx 3675 24 induction induction NN cord-010092-uftc8inx 3675 25 . . . cord-010092-uftc8inx 3676 1 In in IN cord-010092-uftc8inx 3676 2 this this DT cord-010092-uftc8inx 3676 3 presentation presentation NN cord-010092-uftc8inx 3676 4 , , , cord-010092-uftc8inx 3676 5 I -PRON- PRP cord-010092-uftc8inx 3676 6 will will MD cord-010092-uftc8inx 3676 7 compare compare VB cord-010092-uftc8inx 3676 8 and and CC cord-010092-uftc8inx 3676 9 contrast contrast VB cord-010092-uftc8inx 3676 10 BCL11A bcl11a NN cord-010092-uftc8inx 3676 11 enhancer enhancer NN cord-010092-uftc8inx 3676 12 editing editing NN cord-010092-uftc8inx 3676 13 to to IN cord-010092-uftc8inx 3676 14 other other JJ cord-010092-uftc8inx 3676 15 autologous autologous JJ cord-010092-uftc8inx 3676 16 curative curative JJ cord-010092-uftc8inx 3676 17 gene gene NN cord-010092-uftc8inx 3676 18 therapy therapy NN cord-010092-uftc8inx 3676 19 and and CC cord-010092-uftc8inx 3676 20 gene gene NN cord-010092-uftc8inx 3676 21 editing editing NN cord-010092-uftc8inx 3676 22 approaches approach NNS cord-010092-uftc8inx 3676 23 at at IN cord-010092-uftc8inx 3676 24 various various JJ cord-010092-uftc8inx 3676 25 stages stage NNS cord-010092-uftc8inx 3676 26 of of IN cord-010092-uftc8inx 3676 27 clinical clinical JJ cord-010092-uftc8inx 3676 28 and and CC cord-010092-uftc8inx 3676 29 pre pre JJ cord-010092-uftc8inx 3676 30 - - JJ cord-010092-uftc8inx 3676 31 clinical clinical JJ cord-010092-uftc8inx 3676 32 evaluation evaluation NN cord-010092-uftc8inx 3676 33 . . . cord-010092-uftc8inx 3677 1 Oxygen oxygen NN cord-010092-uftc8inx 3677 2 is be VBZ cord-010092-uftc8inx 3677 3 vital vital JJ cord-010092-uftc8inx 3677 4 for for IN cord-010092-uftc8inx 3677 5 life life NN cord-010092-uftc8inx 3677 6 . . . cord-010092-uftc8inx 3678 1 Without without IN cord-010092-uftc8inx 3678 2 oxygen oxygen NN cord-010092-uftc8inx 3678 3 death death NN cord-010092-uftc8inx 3678 4 is be VBZ cord-010092-uftc8inx 3678 5 assured assure VBN cord-010092-uftc8inx 3678 6 for for IN cord-010092-uftc8inx 3678 7 aerobic aerobic JJ cord-010092-uftc8inx 3678 8 organisms organism NNS cord-010092-uftc8inx 3678 9 . . . cord-010092-uftc8inx 3679 1 Although although IN cord-010092-uftc8inx 3679 2 everybody everybody NN cord-010092-uftc8inx 3679 3 knows know VBZ cord-010092-uftc8inx 3679 4 this this DT cord-010092-uftc8inx 3679 5 fact fact NN cord-010092-uftc8inx 3679 6 a a DT cord-010092-uftc8inx 3679 7 lot lot NN cord-010092-uftc8inx 3679 8 of of IN cord-010092-uftc8inx 3679 9 medical medical JJ cord-010092-uftc8inx 3679 10 acts act NNS cord-010092-uftc8inx 3679 11 forget forget VBP cord-010092-uftc8inx 3679 12 to to TO cord-010092-uftc8inx 3679 13 take take VB cord-010092-uftc8inx 3679 14 care care NN cord-010092-uftc8inx 3679 15 of of IN cord-010092-uftc8inx 3679 16 it -PRON- PRP cord-010092-uftc8inx 3679 17 , , , cord-010092-uftc8inx 3679 18 leading lead VBG cord-010092-uftc8inx 3679 19 to to IN cord-010092-uftc8inx 3679 20 a a DT cord-010092-uftc8inx 3679 21 lot lot NN cord-010092-uftc8inx 3679 22 of of IN cord-010092-uftc8inx 3679 23 potential potential JJ cord-010092-uftc8inx 3679 24 troubles trouble NNS cord-010092-uftc8inx 3679 25 . . . cord-010092-uftc8inx 3680 1 Indeed indeed RB cord-010092-uftc8inx 3680 2 , , , cord-010092-uftc8inx 3680 3 during during IN cord-010092-uftc8inx 3680 4 cell cell NN cord-010092-uftc8inx 3680 5 respiration respiration NN cord-010092-uftc8inx 3680 6 the the DT cord-010092-uftc8inx 3680 7 glucose glucose NN cord-010092-uftc8inx 3680 8 oxidation oxidation NN cord-010092-uftc8inx 3680 9 by by IN cord-010092-uftc8inx 3680 10 oxygen oxygen NN cord-010092-uftc8inx 3680 11 gives give VBZ cord-010092-uftc8inx 3680 12 carbon carbon NN cord-010092-uftc8inx 3680 13 dioxide dioxide NN cord-010092-uftc8inx 3680 14 , , , cord-010092-uftc8inx 3680 15 water water NN cord-010092-uftc8inx 3680 16 and and CC cord-010092-uftc8inx 3680 17 energy energy NN cord-010092-uftc8inx 3680 18 . . . cord-010092-uftc8inx 3681 1 This this DT cord-010092-uftc8inx 3681 2 energy energy NN cord-010092-uftc8inx 3681 3 also also RB cord-010092-uftc8inx 3681 4 called call VBD cord-010092-uftc8inx 3681 5 ATP ATP NNP cord-010092-uftc8inx 3681 6 is be VBZ cord-010092-uftc8inx 3681 7 necessary necessary JJ cord-010092-uftc8inx 3681 8 for for IN cord-010092-uftc8inx 3681 9 cellular cellular JJ cord-010092-uftc8inx 3681 10 metabolism metabolism NN cord-010092-uftc8inx 3681 11 and and CC cord-010092-uftc8inx 3681 12 consequently consequently RB cord-010092-uftc8inx 3681 13 for for IN cord-010092-uftc8inx 3681 14 life life NN cord-010092-uftc8inx 3681 15 . . . cord-010092-uftc8inx 3682 1 We -PRON- PRP cord-010092-uftc8inx 3682 2 have have VBP cord-010092-uftc8inx 3682 3 identified identify VBN cord-010092-uftc8inx 3682 4 an an DT cord-010092-uftc8inx 3682 5 extracellular extracellular JJ cord-010092-uftc8inx 3682 6 hemoglobin hemoglobin NN cord-010092-uftc8inx 3682 7 coming come VBG cord-010092-uftc8inx 3682 8 from from IN cord-010092-uftc8inx 3682 9 a a DT cord-010092-uftc8inx 3682 10 marine marine JJ cord-010092-uftc8inx 3682 11 worm worm NN cord-010092-uftc8inx 3682 12 , , , cord-010092-uftc8inx 3682 13 called call VBN cord-010092-uftc8inx 3682 14 Arenicola Arenicola NNP cord-010092-uftc8inx 3682 15 marina marina NN cord-010092-uftc8inx 3682 16 , , , cord-010092-uftc8inx 3682 17 which which WDT cord-010092-uftc8inx 3682 18 is be VBZ cord-010092-uftc8inx 3682 19 able able JJ cord-010092-uftc8inx 3682 20 to to TO cord-010092-uftc8inx 3682 21 deliver deliver VB cord-010092-uftc8inx 3682 22 oxygen oxygen NN cord-010092-uftc8inx 3682 23 to to IN cord-010092-uftc8inx 3682 24 this this DT cord-010092-uftc8inx 3682 25 animal animal NN cord-010092-uftc8inx 3682 26 living live VBG cord-010092-uftc8inx 3682 27 in in IN cord-010092-uftc8inx 3682 28 the the DT cord-010092-uftc8inx 3682 29 intertidal intertidal JJ cord-010092-uftc8inx 3682 30 areas area NNS cord-010092-uftc8inx 3682 31 on on IN cord-010092-uftc8inx 3682 32 the the DT cord-010092-uftc8inx 3682 33 Atlantic atlantic JJ cord-010092-uftc8inx 3682 34 coast coast NN cord-010092-uftc8inx 3682 35 in in IN cord-010092-uftc8inx 3682 36 France France NNP cord-010092-uftc8inx 3682 37 between between IN cord-010092-uftc8inx 3682 38 the the DT cord-010092-uftc8inx 3682 39 North North NNP cord-010092-uftc8inx 3682 40 Sea Sea NNP cord-010092-uftc8inx 3682 41 and and CC cord-010092-uftc8inx 3682 42 Biarritz Biarritz NNP cord-010092-uftc8inx 3682 43 . . . cord-010092-uftc8inx 3683 1 This this DT cord-010092-uftc8inx 3683 2 molecule molecule NN cord-010092-uftc8inx 3683 3 called call VBN cord-010092-uftc8inx 3683 4 M101 M101 NNP cord-010092-uftc8inx 3683 5 was be VBD cord-010092-uftc8inx 3683 6 developed develop VBN cord-010092-uftc8inx 3683 7 in in IN cord-010092-uftc8inx 3683 8 the the DT cord-010092-uftc8inx 3683 9 medical medical JJ cord-010092-uftc8inx 3683 10 device device NN cord-010092-uftc8inx 3683 11 named name VBN cord-010092-uftc8inx 3683 12 HEMO HEMO NNP cord-010092-uftc8inx 3683 13 2 2 CD cord-010092-uftc8inx 3683 14 life life NN cord-010092-uftc8inx 3683 15 â â CD cord-010092-uftc8inx 3683 16 . . . cord-010092-uftc8inx 3684 1 We -PRON- PRP cord-010092-uftc8inx 3684 2 have have VBP cord-010092-uftc8inx 3684 3 showed show VBN cord-010092-uftc8inx 3684 4 that that IN cord-010092-uftc8inx 3684 5 this this DT cord-010092-uftc8inx 3684 6 product product NN cord-010092-uftc8inx 3684 7 was be VBD cord-010092-uftc8inx 3684 8 very very RB cord-010092-uftc8inx 3684 9 efficient efficient JJ cord-010092-uftc8inx 3684 10 to to TO cord-010092-uftc8inx 3684 11 protect protect VB cord-010092-uftc8inx 3684 12 organs organ NNS cord-010092-uftc8inx 3684 13 before before IN cord-010092-uftc8inx 3684 14 transplantation transplantation NN cord-010092-uftc8inx 3684 15 . . . cord-010092-uftc8inx 3685 1 A a DT cord-010092-uftc8inx 3685 2 multi multi JJ cord-010092-uftc8inx 3685 3 centers center NNS cord-010092-uftc8inx 3685 4 clinical clinical JJ cord-010092-uftc8inx 3685 5 trial trial NN cord-010092-uftc8inx 3685 6 performed perform VBN cord-010092-uftc8inx 3685 7 under under IN cord-010092-uftc8inx 3685 8 the the DT cord-010092-uftc8inx 3685 9 supervision supervision NN cord-010092-uftc8inx 3685 10 of of IN cord-010092-uftc8inx 3685 11 Pr Pr NNP cord-010092-uftc8inx 3685 12 . . . cord-010092-uftc8inx 3686 1 Le Le NNP cord-010092-uftc8inx 3686 2 Meur Meur NNP cord-010092-uftc8inx 3686 3 from from IN cord-010092-uftc8inx 3686 4 the the DT cord-010092-uftc8inx 3686 5 CHU CHU NNP cord-010092-uftc8inx 3686 6 of of IN cord-010092-uftc8inx 3686 7 Brest Brest NNP cord-010092-uftc8inx 3686 8 , , , cord-010092-uftc8inx 3686 9 on on IN cord-010092-uftc8inx 3686 10 60 60 CD cord-010092-uftc8inx 3686 11 patients patient NNS cord-010092-uftc8inx 3686 12 waiting wait VBG cord-010092-uftc8inx 3686 13 kidney kidney NN cord-010092-uftc8inx 3686 14 grafts graft NNS cord-010092-uftc8inx 3686 15 showed show VBD cord-010092-uftc8inx 3686 16 a a DT cord-010092-uftc8inx 3686 17 delay delay NN cord-010092-uftc8inx 3686 18 graft graft NN cord-010092-uftc8inx 3686 19 function function NN cord-010092-uftc8inx 3686 20 reduced reduce VBN cord-010092-uftc8inx 3686 21 roughly roughly RB cord-010092-uftc8inx 3686 22 by by IN cord-010092-uftc8inx 3686 23 three three CD cord-010092-uftc8inx 3686 24 between between IN cord-010092-uftc8inx 3686 25 the the DT cord-010092-uftc8inx 3686 26 two two CD cord-010092-uftc8inx 3686 27 kidneys kidney NNS cord-010092-uftc8inx 3686 28 harvested harvest VBN cord-010092-uftc8inx 3686 29 on on IN cord-010092-uftc8inx 3686 30 the the DT cord-010092-uftc8inx 3686 31 same same JJ cord-010092-uftc8inx 3686 32 donor donor NN cord-010092-uftc8inx 3686 33 with with IN cord-010092-uftc8inx 3686 34 and and CC cord-010092-uftc8inx 3686 35 without without IN cord-010092-uftc8inx 3686 36 HEMO HEMO NNP cord-010092-uftc8inx 3686 37 2 2 CD cord-010092-uftc8inx 3686 38 life life NN cord-010092-uftc8inx 3686 39 â â , cord-010092-uftc8inx 3686 40 and and CC cord-010092-uftc8inx 3686 41 grafted graft VBN cord-010092-uftc8inx 3686 42 on on IN cord-010092-uftc8inx 3686 43 recipients recipient NNS cord-010092-uftc8inx 3686 44 . . . cord-010092-uftc8inx 3687 1 In in IN cord-010092-uftc8inx 3687 2 2018 2018 CD cord-010092-uftc8inx 3687 3 , , , cord-010092-uftc8inx 3687 4 a a DT cord-010092-uftc8inx 3687 5 world world NN cord-010092-uftc8inx 3687 6 first first RB cord-010092-uftc8inx 3687 7 was be VBD cord-010092-uftc8inx 3687 8 realized realize VBN cord-010092-uftc8inx 3687 9 in in IN cord-010092-uftc8inx 3687 10 France France NNP cord-010092-uftc8inx 3687 11 by by IN cord-010092-uftc8inx 3687 12 the the DT cord-010092-uftc8inx 3687 13 Pr pr NN cord-010092-uftc8inx 3687 14 . . . cord-010092-uftc8inx 3688 1 Lantieri Lantieri NNP cord-010092-uftc8inx 3688 2 to to IN cord-010092-uftc8inx 3688 3 Georges Georges NNP cord-010092-uftc8inx 3688 4 Pompidou Pompidou NNP cord-010092-uftc8inx 3688 5 hospital hospital NN cord-010092-uftc8inx 3688 6 in in IN cord-010092-uftc8inx 3688 7 Paris Paris NNP cord-010092-uftc8inx 3688 8 , , , cord-010092-uftc8inx 3688 9 France France NNP cord-010092-uftc8inx 3688 10 . . . cord-010092-uftc8inx 3689 1 Indeed indeed RB cord-010092-uftc8inx 3689 2 , , , cord-010092-uftc8inx 3689 3 it -PRON- PRP cord-010092-uftc8inx 3689 4 was be VBD cord-010092-uftc8inx 3689 5 the the DT cord-010092-uftc8inx 3689 6 first first JJ cord-010092-uftc8inx 3689 7 time time NN cord-010092-uftc8inx 3689 8 that that IN cord-010092-uftc8inx 3689 9 a a DT cord-010092-uftc8inx 3689 10 patient patient NN cord-010092-uftc8inx 3689 11 received receive VBD cord-010092-uftc8inx 3689 12 a a DT cord-010092-uftc8inx 3689 13 second second JJ cord-010092-uftc8inx 3689 14 graft graft NN cord-010092-uftc8inx 3689 15 face face NN cord-010092-uftc8inx 3689 16 . . . cord-010092-uftc8inx 3690 1 This this DT cord-010092-uftc8inx 3690 2 surgery surgery NN cord-010092-uftc8inx 3690 3 was be VBD cord-010092-uftc8inx 3690 4 realized realize VBN cord-010092-uftc8inx 3690 5 with with IN cord-010092-uftc8inx 3690 6 HEMO HEMO NNP cord-010092-uftc8inx 3690 7 2 2 CD cord-010092-uftc8inx 3690 8 life life NN cord-010092-uftc8inx 3690 9 â â , cord-010092-uftc8inx 3690 10 and and CC cord-010092-uftc8inx 3690 11 showed show VBD cord-010092-uftc8inx 3690 12 a a DT cord-010092-uftc8inx 3690 13 very very RB cord-010092-uftc8inx 3690 14 nice nice JJ cord-010092-uftc8inx 3690 15 result result NN cord-010092-uftc8inx 3690 16 according accord VBG cord-010092-uftc8inx 3690 17 the the DT cord-010092-uftc8inx 3690 18 Pr Pr NNP cord-010092-uftc8inx 3690 19 Lantieri Lantieri NNP cord-010092-uftc8inx 3690 20 , , , cord-010092-uftc8inx 3690 21 the the DT cord-010092-uftc8inx 3690 22 anastomosis anastomosis NN cord-010092-uftc8inx 3690 23 were be VBD cord-010092-uftc8inx 3690 24 very very RB cord-010092-uftc8inx 3690 25 easy easy JJ cord-010092-uftc8inx 3690 26 and and CC cord-010092-uftc8inx 3690 27 no no DT cord-010092-uftc8inx 3690 28 edema edema NN cord-010092-uftc8inx 3690 29 was be VBD cord-010092-uftc8inx 3690 30 observed observe VBN cord-010092-uftc8inx 3690 31 . . . cord-010092-uftc8inx 3691 1 Furthermore furthermore RB cord-010092-uftc8inx 3691 2 , , , cord-010092-uftc8inx 3691 3 we -PRON- PRP cord-010092-uftc8inx 3691 4 have have VBP cord-010092-uftc8inx 3691 5 developed develop VBN cord-010092-uftc8inx 3691 6 dressing dress VBG cord-010092-uftc8inx 3691 7 incorporating incorporate VBG cord-010092-uftc8inx 3691 8 M101 m101 NN cord-010092-uftc8inx 3691 9 making make VBG cord-010092-uftc8inx 3691 10 a a DT cord-010092-uftc8inx 3691 11 product product NN cord-010092-uftc8inx 3691 12 called call VBN cord-010092-uftc8inx 3691 13 HEMHealing HEMHealing NNP cord-010092-uftc8inx 3691 14 â â , cord-010092-uftc8inx 3691 15 . . . cord-010092-uftc8inx 3692 1 Preclinical preclinical JJ cord-010092-uftc8inx 3692 2 data datum NNS cord-010092-uftc8inx 3692 3 on on IN cord-010092-uftc8inx 3692 4 diabetic diabetic JJ cord-010092-uftc8inx 3692 5 mice mouse NNS cord-010092-uftc8inx 3692 6 showed show VBD cord-010092-uftc8inx 3692 7 an an DT cord-010092-uftc8inx 3692 8 increase increase NN cord-010092-uftc8inx 3692 9 of of IN cord-010092-uftc8inx 3692 10 healing healing NN cord-010092-uftc8inx 3692 11 process process NN cord-010092-uftc8inx 3692 12 . . . cord-010092-uftc8inx 3693 1 HEMOXYCarrier HEMOXYCarrier NNP cord-010092-uftc8inx 3693 2 â â NNP cord-010092-uftc8inx 3693 3 , , , cord-010092-uftc8inx 3693 4 a a DT cord-010092-uftc8inx 3693 5 therapeutical therapeutical JJ cord-010092-uftc8inx 3693 6 oxygen oxygen NN cord-010092-uftc8inx 3693 7 carrier carrier NN cord-010092-uftc8inx 3693 8 , , , cord-010092-uftc8inx 3693 9 is be VBZ cord-010092-uftc8inx 3693 10 also also RB cord-010092-uftc8inx 3693 11 in in IN cord-010092-uftc8inx 3693 12 progress progress NN cord-010092-uftc8inx 3693 13 of of IN cord-010092-uftc8inx 3693 14 development development NN cord-010092-uftc8inx 3693 15 in in IN cord-010092-uftc8inx 3693 16 order order NN cord-010092-uftc8inx 3693 17 to to TO cord-010092-uftc8inx 3693 18 address address VB cord-010092-uftc8inx 3693 19 ischemic ischemic JJ cord-010092-uftc8inx 3693 20 diseases disease NNS cord-010092-uftc8inx 3693 21 such such JJ cord-010092-uftc8inx 3693 22 as as IN cord-010092-uftc8inx 3693 23 the the DT cord-010092-uftc8inx 3693 24 sickle sickle NN cord-010092-uftc8inx 3693 25 cells cell NNS cord-010092-uftc8inx 3693 26 disease disease NN cord-010092-uftc8inx 3693 27 , , , cord-010092-uftc8inx 3693 28 myocardiac myocardiac NN cord-010092-uftc8inx 3693 29 infraction infraction NN cord-010092-uftc8inx 3693 30 and and CC cord-010092-uftc8inx 3693 31 stroke stroke NN cord-010092-uftc8inx 3693 32 . . . cord-010092-uftc8inx 3694 1 This this DT cord-010092-uftc8inx 3694 2 universal universal JJ cord-010092-uftc8inx 3694 3 oxygen oxygen NN cord-010092-uftc8inx 3694 4 carrier carrier NN cord-010092-uftc8inx 3694 5 without without IN cord-010092-uftc8inx 3694 6 blood blood NN cord-010092-uftc8inx 3694 7 typing typing NN cord-010092-uftc8inx 3694 8 , , , cord-010092-uftc8inx 3694 9 which which WDT cord-010092-uftc8inx 3694 10 is be VBZ cord-010092-uftc8inx 3694 11 the the DT cord-010092-uftc8inx 3694 12 ancestor ancestor NN cord-010092-uftc8inx 3694 13 of of IN cord-010092-uftc8inx 3694 14 our -PRON- PRP$ cord-010092-uftc8inx 3694 15 Red Red NNP cord-010092-uftc8inx 3694 16 Blood Blood NNP cord-010092-uftc8inx 3694 17 Cell Cell NNP cord-010092-uftc8inx 3694 18 containing contain VBG cord-010092-uftc8inx 3694 19 hemoglobin hemoglobin NN cord-010092-uftc8inx 3694 20 showed show VBD cord-010092-uftc8inx 3694 21 that that IN cord-010092-uftc8inx 3694 22 it -PRON- PRP cord-010092-uftc8inx 3694 23 is be VBZ cord-010092-uftc8inx 3694 24 able able JJ cord-010092-uftc8inx 3694 25 to to TO cord-010092-uftc8inx 3694 26 deliver deliver VB cord-010092-uftc8inx 3694 27 oxygen oxygen NN cord-010092-uftc8inx 3694 28 at at IN cord-010092-uftc8inx 3694 29 different different JJ cord-010092-uftc8inx 3694 30 biological biological JJ cord-010092-uftc8inx 3694 31 levels level NNS cord-010092-uftc8inx 3694 32 , , , cord-010092-uftc8inx 3694 33 cellular cellular JJ cord-010092-uftc8inx 3694 34 , , , cord-010092-uftc8inx 3694 35 tissues tissue NNS cord-010092-uftc8inx 3694 36 and and CC cord-010092-uftc8inx 3694 37 organs organ NNS cord-010092-uftc8inx 3694 38 and and CC cord-010092-uftc8inx 3694 39 could could MD cord-010092-uftc8inx 3694 40 address address VB cord-010092-uftc8inx 3694 41 a a DT cord-010092-uftc8inx 3694 42 multitude multitude NN cord-010092-uftc8inx 3694 43 of of IN cord-010092-uftc8inx 3694 44 medical medical JJ cord-010092-uftc8inx 3694 45 applications application NNS cord-010092-uftc8inx 3694 46 . . . cord-010092-uftc8inx 3695 1 Background background NN cord-010092-uftc8inx 3695 2 : : : cord-010092-uftc8inx 3696 1 Main main JJ cord-010092-uftc8inx 3696 2 goal goal NN cord-010092-uftc8inx 3696 3 of of IN cord-010092-uftc8inx 3696 4 transfusion transfusion NN cord-010092-uftc8inx 3696 5 is be VBZ cord-010092-uftc8inx 3696 6 saving save VBG cord-010092-uftc8inx 3696 7 life life NN cord-010092-uftc8inx 3696 8 and/or and/or CC cord-010092-uftc8inx 3696 9 improve improve VB cord-010092-uftc8inx 3696 10 the the DT cord-010092-uftc8inx 3696 11 health health NN cord-010092-uftc8inx 3696 12 status status NN cord-010092-uftc8inx 3696 13 of of IN cord-010092-uftc8inx 3696 14 human human NN cord-010092-uftc8inx 3696 15 by by IN cord-010092-uftc8inx 3696 16 " " `` cord-010092-uftc8inx 3696 17 safe safe JJ cord-010092-uftc8inx 3696 18 blood blood NN cord-010092-uftc8inx 3696 19 " " '' cord-010092-uftc8inx 3696 20 which which WDT cord-010092-uftc8inx 3696 21 needs need VBZ cord-010092-uftc8inx 3696 22 regular regular JJ cord-010092-uftc8inx 3696 23 , , , cord-010092-uftc8inx 3696 24 voluntary voluntary JJ cord-010092-uftc8inx 3696 25 , , , cord-010092-uftc8inx 3696 26 unpaid unpaid JJ cord-010092-uftc8inx 3696 27 blood blood NN cord-010092-uftc8inx 3696 28 donors donor NNS cord-010092-uftc8inx 3696 29 . . . cord-010092-uftc8inx 3697 1 Donor donor NN cord-010092-uftc8inx 3697 2 recruitment recruitment NN cord-010092-uftc8inx 3697 3 is be VBZ cord-010092-uftc8inx 3697 4 being be VBG cord-010092-uftc8inx 3697 5 more more RBR cord-010092-uftc8inx 3697 6 sensitive sensitive JJ cord-010092-uftc8inx 3697 7 and and CC cord-010092-uftc8inx 3697 8 challenging challenging JJ cord-010092-uftc8inx 3697 9 part part NN cord-010092-uftc8inx 3697 10 of of IN cord-010092-uftc8inx 3697 11 the the DT cord-010092-uftc8inx 3697 12 blood blood NN cord-010092-uftc8inx 3697 13 supply supply NN cord-010092-uftc8inx 3697 14 system system NN cord-010092-uftc8inx 3697 15 in in IN cord-010092-uftc8inx 3697 16 actual actual JJ cord-010092-uftc8inx 3697 17 global global JJ cord-010092-uftc8inx 3697 18 socio socio JJ cord-010092-uftc8inx 3697 19 - - HYPH cord-010092-uftc8inx 3697 20 economic economic JJ cord-010092-uftc8inx 3697 21 conditions condition NNS cord-010092-uftc8inx 3697 22 . . . cord-010092-uftc8inx 3698 1 Achievement achievement NN cord-010092-uftc8inx 3698 2 to to IN cord-010092-uftc8inx 3698 3 enough enough JJ cord-010092-uftc8inx 3698 4 voluntary voluntary JJ cord-010092-uftc8inx 3698 5 non non JJ cord-010092-uftc8inx 3698 6 - - JJ cord-010092-uftc8inx 3698 7 remunerated remunerated JJ cord-010092-uftc8inx 3698 8 blood blood NN cord-010092-uftc8inx 3698 9 donation donation NN cord-010092-uftc8inx 3698 10 ( ( -LRB- cord-010092-uftc8inx 3698 11 VNRBD VNRBD NNP cord-010092-uftc8inx 3698 12 ) ) -RRB- cord-010092-uftc8inx 3698 13 can can MD cord-010092-uftc8inx 3698 14 be be VB cord-010092-uftc8inx 3698 15 established establish VBN cord-010092-uftc8inx 3698 16 by by IN cord-010092-uftc8inx 3698 17 an an DT cord-010092-uftc8inx 3698 18 efficient efficient JJ cord-010092-uftc8inx 3698 19 donor donor NN cord-010092-uftc8inx 3698 20 recruitment recruitment NN cord-010092-uftc8inx 3698 21 . . . cord-010092-uftc8inx 3699 1 Efficiency efficiency NN cord-010092-uftc8inx 3699 2 of of IN cord-010092-uftc8inx 3699 3 the the DT cord-010092-uftc8inx 3699 4 donor donor NN cord-010092-uftc8inx 3699 5 recruitment recruitment NN cord-010092-uftc8inx 3699 6 has have VBZ cord-010092-uftc8inx 3699 7 still still RB cord-010092-uftc8inx 3699 8 close close JJ cord-010092-uftc8inx 3699 9 relation relation NN cord-010092-uftc8inx 3699 10 with with IN cord-010092-uftc8inx 3699 11 blood blood NN cord-010092-uftc8inx 3699 12 donor donor NN cord-010092-uftc8inx 3699 13 recruiter recruiter NN cord-010092-uftc8inx 3699 14 although although IN cord-010092-uftc8inx 3699 15 there there EX cord-010092-uftc8inx 3699 16 are be VBP cord-010092-uftc8inx 3699 17 so so RB cord-010092-uftc8inx 3699 18 many many JJ cord-010092-uftc8inx 3699 19 new new JJ cord-010092-uftc8inx 3699 20 tools tool NNS cord-010092-uftc8inx 3699 21 . . . cord-010092-uftc8inx 3700 1 Occupational occupational JJ cord-010092-uftc8inx 3700 2 specifications specification NNS cord-010092-uftc8inx 3700 3 , , , cord-010092-uftc8inx 3700 4 rights right NNS cord-010092-uftc8inx 3700 5 and and CC cord-010092-uftc8inx 3700 6 responsibilities responsibility NNS cord-010092-uftc8inx 3700 7 of of IN cord-010092-uftc8inx 3700 8 blood blood NN cord-010092-uftc8inx 3700 9 donor donor NN cord-010092-uftc8inx 3700 10 recruiter recruiter NN cord-010092-uftc8inx 3700 11 have have VBP cord-010092-uftc8inx 3700 12 wide wide JJ cord-010092-uftc8inx 3700 13 range range NN cord-010092-uftc8inx 3700 14 differences difference NNS cord-010092-uftc8inx 3700 15 between between IN cord-010092-uftc8inx 3700 16 countries country NNS cord-010092-uftc8inx 3700 17 which which WDT cord-010092-uftc8inx 3700 18 can can MD cord-010092-uftc8inx 3700 19 not not RB cord-010092-uftc8inx 3700 20 be be VB cord-010092-uftc8inx 3700 21 explained explain VBN cord-010092-uftc8inx 3700 22 completely completely RB cord-010092-uftc8inx 3700 23 by by IN cord-010092-uftc8inx 3700 24 the the DT cord-010092-uftc8inx 3700 25 specific specific JJ cord-010092-uftc8inx 3700 26 conditions condition NNS cord-010092-uftc8inx 3700 27 of of IN cord-010092-uftc8inx 3700 28 each each DT cord-010092-uftc8inx 3700 29 country country NN cord-010092-uftc8inx 3700 30 . . . cord-010092-uftc8inx 3701 1 Also also RB cord-010092-uftc8inx 3701 2 , , , cord-010092-uftc8inx 3701 3 a a DT cord-010092-uftc8inx 3701 4 concrete concrete JJ cord-010092-uftc8inx 3701 5 document document NN cord-010092-uftc8inx 3701 6 which which WDT cord-010092-uftc8inx 3701 7 has have VBZ cord-010092-uftc8inx 3701 8 an an DT cord-010092-uftc8inx 3701 9 international international JJ cord-010092-uftc8inx 3701 10 consensus consensus NN cord-010092-uftc8inx 3701 11 was be VBD cord-010092-uftc8inx 3701 12 not not RB cord-010092-uftc8inx 3701 13 existing exist VBG cord-010092-uftc8inx 3701 14 on on IN cord-010092-uftc8inx 3701 15 this this DT cord-010092-uftc8inx 3701 16 subject subject NN cord-010092-uftc8inx 3701 17 . . . cord-010092-uftc8inx 3702 1 Turkish Turkish NNP cord-010092-uftc8inx 3702 2 Blood Blood NNP cord-010092-uftc8inx 3702 3 Foundation Foundation NNP cord-010092-uftc8inx 3702 4 ( ( -LRB- cord-010092-uftc8inx 3702 5 TBF TBF NNP cord-010092-uftc8inx 3702 6 ) ) -RRB- cord-010092-uftc8inx 3702 7 has have VBZ cord-010092-uftc8inx 3702 8 been be VBN cord-010092-uftc8inx 3702 9 organizing organize VBG cord-010092-uftc8inx 3702 10 an an DT cord-010092-uftc8inx 3702 11 international international JJ cord-010092-uftc8inx 3702 12 workshop workshop NN cord-010092-uftc8inx 3702 13 since since IN cord-010092-uftc8inx 3702 14 2012 2012 CD cord-010092-uftc8inx 3702 15 ; ; : cord-010092-uftc8inx 3702 16 Anatolian Anatolian NNP cord-010092-uftc8inx 3702 17 Blood blood NN cord-010092-uftc8inx 3702 18 Days day NNS cord-010092-uftc8inx 3702 19 ( ( -LRB- cord-010092-uftc8inx 3702 20 ABD ABD NNP cord-010092-uftc8inx 3702 21 ) ) -RRB- cord-010092-uftc8inx 3702 22 . . . cord-010092-uftc8inx 3703 1 " " `` cord-010092-uftc8inx 3703 2 Who who WP cord-010092-uftc8inx 3703 3 is be VBZ cord-010092-uftc8inx 3703 4 a a DT cord-010092-uftc8inx 3703 5 blood blood NN cord-010092-uftc8inx 3703 6 donor donor NN cord-010092-uftc8inx 3703 7 recruiter recruiter NN cord-010092-uftc8inx 3703 8 ? ? . cord-010092-uftc8inx 3703 9 " " '' cord-010092-uftc8inx 3703 10 was be VBD cord-010092-uftc8inx 3703 11 the the DT cord-010092-uftc8inx 3703 12 topic topic NN cord-010092-uftc8inx 3703 13 of of IN cord-010092-uftc8inx 3703 14 ABD ABD NNP cord-010092-uftc8inx 3703 15 - - HYPH cord-010092-uftc8inx 3703 16 VII VII NNP cord-010092-uftc8inx 3703 17 at at IN cord-010092-uftc8inx 3703 18 9 9 CD cord-010092-uftc8inx 3703 19 - - SYM cord-010092-uftc8inx 3703 20 11 11 CD cord-010092-uftc8inx 3703 21 March March NNP cord-010092-uftc8inx 3703 22 2018 2018 CD cord-010092-uftc8inx 3703 23 . . . cord-010092-uftc8inx 3704 1 Aims aim VBZ cord-010092-uftc8inx 3704 2 : : : cord-010092-uftc8inx 3705 1 Main main JJ cord-010092-uftc8inx 3705 2 aim aim NN cord-010092-uftc8inx 3705 3 of of IN cord-010092-uftc8inx 3705 4 the the DT cord-010092-uftc8inx 3705 5 workshop workshop NN cord-010092-uftc8inx 3705 6 was be VBD cord-010092-uftc8inx 3705 7 to to TO cord-010092-uftc8inx 3705 8 check check VB cord-010092-uftc8inx 3705 9 and and CC cord-010092-uftc8inx 3705 10 evaluate evaluate VB cord-010092-uftc8inx 3705 11 the the DT cord-010092-uftc8inx 3705 12 existing exist VBG cord-010092-uftc8inx 3705 13 systems system NNS cord-010092-uftc8inx 3705 14 of of IN cord-010092-uftc8inx 3705 15 the the DT cord-010092-uftc8inx 3705 16 participant participant NN cord-010092-uftc8inx 3705 17 countries country NNS cord-010092-uftc8inx 3705 18 . . . cord-010092-uftc8inx 3706 1 Than than IN cord-010092-uftc8inx 3706 2 create create VB cord-010092-uftc8inx 3706 3 a a DT cord-010092-uftc8inx 3706 4 model model NN cord-010092-uftc8inx 3706 5 for for IN cord-010092-uftc8inx 3706 6 clearly clearly RB cord-010092-uftc8inx 3706 7 defining define VBG cord-010092-uftc8inx 3706 8 occupational occupational JJ cord-010092-uftc8inx 3706 9 specifications specification NNS cord-010092-uftc8inx 3706 10 , , , cord-010092-uftc8inx 3706 11 responsibilities responsibility NNS cord-010092-uftc8inx 3706 12 and and CC cord-010092-uftc8inx 3706 13 rights right NNS cord-010092-uftc8inx 3706 14 of of IN cord-010092-uftc8inx 3706 15 blood blood NN cord-010092-uftc8inx 3706 16 donor donor NN cord-010092-uftc8inx 3706 17 recruiter recruiter NN cord-010092-uftc8inx 3706 18 . . . cord-010092-uftc8inx 3707 1 Methods method NNS cord-010092-uftc8inx 3707 2 : : : cord-010092-uftc8inx 3707 3 Experts expert NNS cord-010092-uftc8inx 3707 4 from from IN cord-010092-uftc8inx 3707 5 25 25 CD cord-010092-uftc8inx 3707 6 countries country NNS cord-010092-uftc8inx 3707 7 participated participate VBD cord-010092-uftc8inx 3707 8 in in IN cord-010092-uftc8inx 3707 9 the the DT cord-010092-uftc8inx 3707 10 workshop workshop NN cord-010092-uftc8inx 3707 11 . . . cord-010092-uftc8inx 3708 1 Those those DT cord-010092-uftc8inx 3708 2 countries country NNS cord-010092-uftc8inx 3708 3 are be VBP cord-010092-uftc8inx 3708 4 Albania Albania NNP cord-010092-uftc8inx 3708 5 , , , cord-010092-uftc8inx 3708 6 Algeria Algeria NNP cord-010092-uftc8inx 3708 7 , , , cord-010092-uftc8inx 3708 8 Bosnia Bosnia NNP cord-010092-uftc8inx 3708 9 - - HYPH cord-010092-uftc8inx 3708 10 Herzegovina Herzegovina NNP cord-010092-uftc8inx 3708 11 , , , cord-010092-uftc8inx 3708 12 Estonia Estonia NNP cord-010092-uftc8inx 3708 13 , , , cord-010092-uftc8inx 3708 14 France France NNP cord-010092-uftc8inx 3708 15 , , , cord-010092-uftc8inx 3708 16 Germany Germany NNP cord-010092-uftc8inx 3708 17 , , , cord-010092-uftc8inx 3708 18 Hungary Hungary NNP cord-010092-uftc8inx 3708 19 , , , cord-010092-uftc8inx 3708 20 India India NNP cord-010092-uftc8inx 3708 21 , , , cord-010092-uftc8inx 3708 22 Kazakhstan Kazakhstan NNP cord-010092-uftc8inx 3708 23 , , , cord-010092-uftc8inx 3708 24 Lithuania Lithuania NNP cord-010092-uftc8inx 3708 25 , , , cord-010092-uftc8inx 3708 26 Macedonia Macedonia NNP cord-010092-uftc8inx 3708 27 , , , cord-010092-uftc8inx 3708 28 Montenegro Montenegro NNP cord-010092-uftc8inx 3708 29 , , , cord-010092-uftc8inx 3708 30 Oman Oman NNP cord-010092-uftc8inx 3708 31 , , , cord-010092-uftc8inx 3708 32 Portugal Portugal NNP cord-010092-uftc8inx 3708 33 , , , cord-010092-uftc8inx 3708 34 Qatar Qatar NNP cord-010092-uftc8inx 3708 35 , , , cord-010092-uftc8inx 3708 36 Romania Romania NNP cord-010092-uftc8inx 3708 37 , , , cord-010092-uftc8inx 3708 38 Russia Russia NNP cord-010092-uftc8inx 3708 39 , , , cord-010092-uftc8inx 3708 40 Saudi Saudi NNP cord-010092-uftc8inx 3708 41 Arabia Arabia NNP cord-010092-uftc8inx 3708 42 , , , cord-010092-uftc8inx 3708 43 Serbia Serbia NNP cord-010092-uftc8inx 3708 44 , , , cord-010092-uftc8inx 3708 45 Slovenia Slovenia NNP cord-010092-uftc8inx 3708 46 , , , cord-010092-uftc8inx 3708 47 Sri Sri NNP cord-010092-uftc8inx 3708 48 Lanka Lanka NNP cord-010092-uftc8inx 3708 49 , , , cord-010092-uftc8inx 3708 50 Tajikistan Tajikistan NNP cord-010092-uftc8inx 3708 51 , , , cord-010092-uftc8inx 3708 52 Turkey Turkey NNP cord-010092-uftc8inx 3708 53 , , , cord-010092-uftc8inx 3708 54 Uganda Uganda NNP cord-010092-uftc8inx 3708 55 , , , cord-010092-uftc8inx 3708 56 Uzbekistan Uzbekistan NNP cord-010092-uftc8inx 3708 57 . . . cord-010092-uftc8inx 3709 1 These these DT cord-010092-uftc8inx 3709 2 countries country NNS cord-010092-uftc8inx 3709 3 reflect reflect VBP cord-010092-uftc8inx 3709 4 almost almost RB cord-010092-uftc8inx 3709 5 all all DT cord-010092-uftc8inx 3709 6 religious religious JJ cord-010092-uftc8inx 3709 7 , , , cord-010092-uftc8inx 3709 8 ethnical ethnical JJ cord-010092-uftc8inx 3709 9 , , , cord-010092-uftc8inx 3709 10 social social JJ cord-010092-uftc8inx 3709 11 , , , cord-010092-uftc8inx 3709 12 cultural cultural JJ cord-010092-uftc8inx 3709 13 and and CC cord-010092-uftc8inx 3709 14 economic economic JJ cord-010092-uftc8inx 3709 15 situations situation NNS cord-010092-uftc8inx 3709 16 of of IN cord-010092-uftc8inx 3709 17 the the DT cord-010092-uftc8inx 3709 18 world world NN cord-010092-uftc8inx 3709 19 . . . cord-010092-uftc8inx 3710 1 A a DT cord-010092-uftc8inx 3710 2 questionnaire questionnaire NN cord-010092-uftc8inx 3710 3 which which WDT cord-010092-uftc8inx 3710 4 was be VBD cord-010092-uftc8inx 3710 5 analyzing analyze VBG cord-010092-uftc8inx 3710 6 existing exist VBG cord-010092-uftc8inx 3710 7 systems system NNS cord-010092-uftc8inx 3710 8 at at IN cord-010092-uftc8inx 3710 9 participant participant NN cord-010092-uftc8inx 3710 10 countries country NNS cord-010092-uftc8inx 3710 11 sent send VBN cord-010092-uftc8inx 3710 12 before before IN cord-010092-uftc8inx 3710 13 the the DT cord-010092-uftc8inx 3710 14 workshop workshop NN cord-010092-uftc8inx 3710 15 . . . cord-010092-uftc8inx 3711 1 After after IN cord-010092-uftc8inx 3711 2 country country NN cord-010092-uftc8inx 3711 3 presentations presentation NNS cord-010092-uftc8inx 3711 4 4 4 CD cord-010092-uftc8inx 3711 5 different different JJ cord-010092-uftc8inx 3711 6 discussion discussion NN cord-010092-uftc8inx 3711 7 groups group NNS cord-010092-uftc8inx 3711 8 were be VBD cord-010092-uftc8inx 3711 9 organized organize VBN cord-010092-uftc8inx 3711 10 . . . cord-010092-uftc8inx 3712 1 Below below IN cord-010092-uftc8inx 3712 2 listed list VBN cord-010092-uftc8inx 3712 3 topics topic NNS cord-010092-uftc8inx 3712 4 were be VBD cord-010092-uftc8inx 3712 5 announced announce VBN cord-010092-uftc8inx 3712 6 at at IN cord-010092-uftc8inx 3712 7 final final JJ cord-010092-uftc8inx 3712 8 declaration declaration NN cord-010092-uftc8inx 3712 9 . . . cord-010092-uftc8inx 3713 1 Results result NNS cord-010092-uftc8inx 3713 2 : : : cord-010092-uftc8inx 3714 1 Donor donor NN cord-010092-uftc8inx 3714 2 recruiter recruiter NN cord-010092-uftc8inx 3714 3 : : : cord-010092-uftc8inx 3714 4 1 1 LS cord-010092-uftc8inx 3714 5 . . . cord-010092-uftc8inx 3714 6 should should MD cord-010092-uftc8inx 3714 7 have have VB cord-010092-uftc8inx 3714 8 University University NNP cord-010092-uftc8inx 3714 9 degree degree NN cord-010092-uftc8inx 3714 10 preferably preferably RB cord-010092-uftc8inx 3714 11 in in IN cord-010092-uftc8inx 3714 12 Marketing Marketing NNP cord-010092-uftc8inx 3714 13 and and CC cord-010092-uftc8inx 3714 14 Business Business NNP cord-010092-uftc8inx 3714 15 Administration Administration NNP cord-010092-uftc8inx 3714 16 field field NN cord-010092-uftc8inx 3714 17 . . . cord-010092-uftc8inx 3715 1 2 2 LS cord-010092-uftc8inx 3715 2 . . . cord-010092-uftc8inx 3715 3 should should MD cord-010092-uftc8inx 3715 4 have have VB cord-010092-uftc8inx 3715 5 a a DT cord-010092-uftc8inx 3715 6 certificate certificate NN cord-010092-uftc8inx 3715 7 and/or and/or CC cord-010092-uftc8inx 3715 8 professional professional JJ cord-010092-uftc8inx 3715 9 experience experience NN cord-010092-uftc8inx 3715 10 in in IN cord-010092-uftc8inx 3715 11 Public Public NNP cord-010092-uftc8inx 3715 12 Relation Relation NNP cord-010092-uftc8inx 3715 13 3 3 CD cord-010092-uftc8inx 3715 14 . . . cord-010092-uftc8inx 3715 15 should should MD cord-010092-uftc8inx 3715 16 have have VB cord-010092-uftc8inx 3715 17 efficient efficient JJ cord-010092-uftc8inx 3715 18 skill skill NN cord-010092-uftc8inx 3715 19 in in IN cord-010092-uftc8inx 3715 20 conversation conversation NN cord-010092-uftc8inx 3715 21 , , , cord-010092-uftc8inx 3715 22 sociability sociability NN cord-010092-uftc8inx 3715 23 , , , cord-010092-uftc8inx 3715 24 independence independence NN cord-010092-uftc8inx 3715 25 , , , cord-010092-uftc8inx 3715 26 self self NN cord-010092-uftc8inx 3715 27 - - HYPH cord-010092-uftc8inx 3715 28 confidence confidence NN cord-010092-uftc8inx 3715 29 , , , cord-010092-uftc8inx 3715 30 reliability reliability NN cord-010092-uftc8inx 3715 31 , , , cord-010092-uftc8inx 3715 32 resilience resilience NN cord-010092-uftc8inx 3715 33 and and CC cord-010092-uftc8inx 3715 34 conscientiousness conscientiousness NN cord-010092-uftc8inx 3715 35 as as RB cord-010092-uftc8inx 3715 36 well well RB cord-010092-uftc8inx 3715 37 as as IN cord-010092-uftc8inx 3715 38 to to TO cord-010092-uftc8inx 3715 39 work work VB cord-010092-uftc8inx 3715 40 in in IN cord-010092-uftc8inx 3715 41 a a DT cord-010092-uftc8inx 3715 42 team team NN cord-010092-uftc8inx 3715 43 4 4 CD cord-010092-uftc8inx 3715 44 . . . cord-010092-uftc8inx 3715 45 should should MD cord-010092-uftc8inx 3715 46 get get VB cord-010092-uftc8inx 3715 47 a a DT cord-010092-uftc8inx 3715 48 special special JJ cord-010092-uftc8inx 3715 49 training training NN cord-010092-uftc8inx 3715 50 which which WDT cord-010092-uftc8inx 3715 51 includes include VBZ cord-010092-uftc8inx 3715 52 not not RB cord-010092-uftc8inx 3715 53 only only RB cord-010092-uftc8inx 3715 54 social social JJ cord-010092-uftc8inx 3715 55 topics topic NNS cord-010092-uftc8inx 3715 56 such such JJ cord-010092-uftc8inx 3715 57 as as IN cord-010092-uftc8inx 3715 58 public public JJ cord-010092-uftc8inx 3715 59 relation relation NN cord-010092-uftc8inx 3715 60 , , , cord-010092-uftc8inx 3715 61 marketing marketing NN cord-010092-uftc8inx 3715 62 , , , cord-010092-uftc8inx 3715 63 etc etc FW cord-010092-uftc8inx 3715 64 . . . cord-010092-uftc8inx 3716 1 and and CC cord-010092-uftc8inx 3716 2 medical medical JJ cord-010092-uftc8inx 3716 3 topics topic NNS cord-010092-uftc8inx 3716 4 related relate VBD cord-010092-uftc8inx 3716 5 BB&TM BB&TM NNP cord-010092-uftc8inx 3716 6 before before IN cord-010092-uftc8inx 3716 7 practicing practice VBG cord-010092-uftc8inx 3716 8 alone alone RB cord-010092-uftc8inx 3716 9 as as IN cord-010092-uftc8inx 3716 10 a a DT cord-010092-uftc8inx 3716 11 donor donor NN cord-010092-uftc8inx 3716 12 recruiter recruiter NN cord-010092-uftc8inx 3716 13 5 5 CD cord-010092-uftc8inx 3716 14 . . . cord-010092-uftc8inx 3717 1 should should MD cord-010092-uftc8inx 3717 2 be be VB cord-010092-uftc8inx 3717 3 a a DT cord-010092-uftc8inx 3717 4 permanent permanent JJ cord-010092-uftc8inx 3717 5 staff staff NN cord-010092-uftc8inx 3717 6 6 6 CD cord-010092-uftc8inx 3717 7 . . . cord-010092-uftc8inx 3718 1 should should MD cord-010092-uftc8inx 3718 2 have have VB cord-010092-uftc8inx 3719 1 basic basic JJ cord-010092-uftc8inx 3719 2 salary salary NN cord-010092-uftc8inx 3719 3 and and CC cord-010092-uftc8inx 3719 4 performance performance NN cord-010092-uftc8inx 3719 5 bonus bonus NN cord-010092-uftc8inx 3719 6 might may MD cord-010092-uftc8inx 3719 7 be be VB cord-010092-uftc8inx 3719 8 given give VBN cord-010092-uftc8inx 3719 9 7 7 CD cord-010092-uftc8inx 3719 10 . . . cord-010092-uftc8inx 3720 1 is be VBZ cord-010092-uftc8inx 3720 2 eligible eligible JJ cord-010092-uftc8inx 3720 3 to to TO cord-010092-uftc8inx 3720 4 monitor monitor VB cord-010092-uftc8inx 3720 5 and and CC cord-010092-uftc8inx 3720 6 modify modify VB cord-010092-uftc8inx 3720 7 mobile mobile JJ cord-010092-uftc8inx 3720 8 team team NN cord-010092-uftc8inx 3720 9 working work VBG cord-010092-uftc8inx 3720 10 period period NN cord-010092-uftc8inx 3720 11 at at IN cord-010092-uftc8inx 3720 12 blood blood NN cord-010092-uftc8inx 3720 13 drive drive NN cord-010092-uftc8inx 3720 14 8 8 CD cord-010092-uftc8inx 3720 15 . . . cord-010092-uftc8inx 3721 1 should should MD cord-010092-uftc8inx 3721 2 participate participate VB cord-010092-uftc8inx 3721 3 the the DT cord-010092-uftc8inx 3721 4 mobile mobile JJ cord-010092-uftc8inx 3721 5 blood blood NN cord-010092-uftc8inx 3721 6 drive drive NN cord-010092-uftc8inx 3721 7 which which WDT cord-010092-uftc8inx 3721 8 he -PRON- PRP cord-010092-uftc8inx 3721 9 / / SYM cord-010092-uftc8inx 3721 10 she -PRON- PRP cord-010092-uftc8inx 3721 11 has have VBZ cord-010092-uftc8inx 3721 12 organized organize VBN cord-010092-uftc8inx 3721 13 9 9 CD cord-010092-uftc8inx 3721 14 . . . cord-010092-uftc8inx 3722 1 should should MD cord-010092-uftc8inx 3722 2 participate participate VB cord-010092-uftc8inx 3722 3 the the DT cord-010092-uftc8inx 3722 4 group group NN cord-010092-uftc8inx 3722 5 who who WP cord-010092-uftc8inx 3722 6 will will MD cord-010092-uftc8inx 3722 7 create create VB cord-010092-uftc8inx 3722 8 promotional promotional JJ cord-010092-uftc8inx 3722 9 materials material NNS cord-010092-uftc8inx 3722 10 for for IN cord-010092-uftc8inx 3722 11 national national JJ cord-010092-uftc8inx 3722 12 blood blood NN cord-010092-uftc8inx 3722 13 service service NN cord-010092-uftc8inx 3722 14 10 10 CD cord-010092-uftc8inx 3722 15 . . . cord-010092-uftc8inx 3723 1 number number NN cord-010092-uftc8inx 3723 2 at at IN cord-010092-uftc8inx 3723 3 each each DT cord-010092-uftc8inx 3723 4 blood blood NN cord-010092-uftc8inx 3723 5 establishment establishment NN cord-010092-uftc8inx 3723 6 should should MD cord-010092-uftc8inx 3723 7 be be VB cord-010092-uftc8inx 3723 8 defined define VBN cord-010092-uftc8inx 3723 9 based base VBN cord-010092-uftc8inx 3723 10 on on IN cord-010092-uftc8inx 3723 11 annual annual JJ cord-010092-uftc8inx 3723 12 blood blood NN cord-010092-uftc8inx 3723 13 collection collection NN cord-010092-uftc8inx 3723 14 such such JJ cord-010092-uftc8inx 3723 15 as as IN cord-010092-uftc8inx 3723 16 5 5 CD cord-010092-uftc8inx 3723 17 staffs staff NNS cord-010092-uftc8inx 3723 18 for for IN cord-010092-uftc8inx 3723 19 50,000 50,000 CD cord-010092-uftc8inx 3723 20 whole whole JJ cord-010092-uftc8inx 3723 21 blood blood NN cord-010092-uftc8inx 3723 22 collection collection NN cord-010092-uftc8inx 3723 23 annually annually RB cord-010092-uftc8inx 3723 24 in in IN cord-010092-uftc8inx 3723 25 Germany Germany NNP cord-010092-uftc8inx 3723 26 . . . cord-010092-uftc8inx 3724 1 Summary Summary NNP cord-010092-uftc8inx 3724 2 / / SYM cord-010092-uftc8inx 3724 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 3724 4 : : : cord-010092-uftc8inx 3725 1 In in IN cord-010092-uftc8inx 3725 2 conclusion conclusion NN cord-010092-uftc8inx 3725 3 ; ; : cord-010092-uftc8inx 3725 4 both both DT cord-010092-uftc8inx 3725 5 donor donor NN cord-010092-uftc8inx 3725 6 recruitment recruitment NN cord-010092-uftc8inx 3725 7 and and CC cord-010092-uftc8inx 3725 8 retention retention NN cord-010092-uftc8inx 3725 9 are be VBP cord-010092-uftc8inx 3725 10 not not RB cord-010092-uftc8inx 3725 11 easy easy JJ cord-010092-uftc8inx 3725 12 tasks task NNS cord-010092-uftc8inx 3725 13 to to TO cord-010092-uftc8inx 3725 14 undergo undergo VB cord-010092-uftc8inx 3725 15 while while IN cord-010092-uftc8inx 3725 16 public public JJ cord-010092-uftc8inx 3725 17 are be VBP cord-010092-uftc8inx 3725 18 aging age VBG cord-010092-uftc8inx 3725 19 , , , cord-010092-uftc8inx 3725 20 and and CC cord-010092-uftc8inx 3725 21 birth birth NN cord-010092-uftc8inx 3725 22 rates rate NNS cord-010092-uftc8inx 3725 23 are be VBP cord-010092-uftc8inx 3725 24 decreasing decrease VBG cord-010092-uftc8inx 3725 25 all all RB cord-010092-uftc8inx 3725 26 around around IN cord-010092-uftc8inx 3725 27 the the DT cord-010092-uftc8inx 3725 28 world world NN cord-010092-uftc8inx 3725 29 . . . cord-010092-uftc8inx 3726 1 Dedicated dedicated JJ cord-010092-uftc8inx 3726 2 blood blood NN cord-010092-uftc8inx 3726 3 donor donor NN cord-010092-uftc8inx 3726 4 recruiter recruiter NN cord-010092-uftc8inx 3726 5 whose whose WP$ cord-010092-uftc8inx 3726 6 occupational occupational JJ cord-010092-uftc8inx 3726 7 specifications specification NNS cord-010092-uftc8inx 3726 8 , , , cord-010092-uftc8inx 3726 9 rights right NNS cord-010092-uftc8inx 3726 10 and and CC cord-010092-uftc8inx 3726 11 responsibilities responsibility NNS cord-010092-uftc8inx 3726 12 are be VBP cord-010092-uftc8inx 3726 13 clearly clearly RB cord-010092-uftc8inx 3726 14 defined define VBN cord-010092-uftc8inx 3726 15 will will MD cord-010092-uftc8inx 3726 16 be be VB cord-010092-uftc8inx 3726 17 the the DT cord-010092-uftc8inx 3726 18 corner corner NN cord-010092-uftc8inx 3726 19 stone stone NN cord-010092-uftc8inx 3726 20 of of IN cord-010092-uftc8inx 3726 21 the the DT cord-010092-uftc8inx 3726 22 success success NN cord-010092-uftc8inx 3726 23 for for IN cord-010092-uftc8inx 3726 24 providing provide VBG cord-010092-uftc8inx 3726 25 enough enough JJ cord-010092-uftc8inx 3726 26 safe safe JJ cord-010092-uftc8inx 3726 27 blood blood NN cord-010092-uftc8inx 3726 28 for for IN cord-010092-uftc8inx 3726 29 transfusion transfusion NN cord-010092-uftc8inx 3726 30 . . . cord-010092-uftc8inx 3727 1 CT CT NNP cord-010092-uftc8inx 3727 2 Smit Smit NNP cord-010092-uftc8inx 3727 3 Sibinga Sibinga NNP cord-010092-uftc8inx 3727 4 1 1 CD cord-010092-uftc8inx 3727 5 and and CC cord-010092-uftc8inx 3727 6 J J NNP cord-010092-uftc8inx 3727 7 Emmanuel Emmanuel NNP cord-010092-uftc8inx 3727 8 2 2 CD cord-010092-uftc8inx 3727 9 Background Background NNP cord-010092-uftc8inx 3727 10 : : : cord-010092-uftc8inx 3727 11 Africa Africa NNP cord-010092-uftc8inx 3727 12 is be VBZ cord-010092-uftc8inx 3727 13 a a DT cord-010092-uftc8inx 3727 14 large large JJ cord-010092-uftc8inx 3727 15 continent continent NN cord-010092-uftc8inx 3727 16 with with IN cord-010092-uftc8inx 3727 17 55 55 CD cord-010092-uftc8inx 3727 18 independent independent JJ cord-010092-uftc8inx 3727 19 States States NNPS cord-010092-uftc8inx 3727 20 and and CC cord-010092-uftc8inx 3727 21 a a DT cord-010092-uftc8inx 3727 22 total total JJ cord-010092-uftc8inx 3727 23 population population NN cord-010092-uftc8inx 3727 24 of of IN cord-010092-uftc8inx 3727 25 1,275,710,034 1,275,710,034 CD cord-010092-uftc8inx 3727 26 ( ( -LRB- cord-010092-uftc8inx 3727 27 February February NNP cord-010092-uftc8inx 3727 28 2018 2018 CD cord-010092-uftc8inx 3727 29 ) ) -RRB- cord-010092-uftc8inx 3727 30 . . . cord-010092-uftc8inx 3728 1 Healthcare healthcare NN cord-010092-uftc8inx 3728 2 policies policy NNS cord-010092-uftc8inx 3728 3 and and CC cord-010092-uftc8inx 3728 4 strategies strategy NNS cord-010092-uftc8inx 3728 5 are be VBP cord-010092-uftc8inx 3728 6 developed develop VBN cord-010092-uftc8inx 3728 7 through through IN cord-010092-uftc8inx 3728 8 WHO who WP cord-010092-uftc8inx 3728 9 's 's POS cord-010092-uftc8inx 3728 10 advocacy advocacy NN cord-010092-uftc8inx 3728 11 , , , cord-010092-uftc8inx 3728 12 guidance guidance NN cord-010092-uftc8inx 3728 13 , , , cord-010092-uftc8inx 3728 14 and and CC cord-010092-uftc8inx 3728 15 support support NN cord-010092-uftc8inx 3728 16 from from IN cord-010092-uftc8inx 3728 17 HQ HQ NNP cord-010092-uftc8inx 3728 18 in in IN cord-010092-uftc8inx 3728 19 Geneva Geneva NNP cord-010092-uftc8inx 3728 20 and and CC cord-010092-uftc8inx 3728 21 the the DT cord-010092-uftc8inx 3728 22 2 2 CD cord-010092-uftc8inx 3728 23 WHO who WP cord-010092-uftc8inx 3729 1 Regional Regional NNP cord-010092-uftc8inx 3729 2 Offices Offices NNPS cord-010092-uftc8inx 3729 3 ; ; : cord-010092-uftc8inx 3729 4 Eastern Eastern NNP cord-010092-uftc8inx 3729 5 Mediterranean Mediterranean NNP cord-010092-uftc8inx 3729 6 Regional Regional NNP cord-010092-uftc8inx 3729 7 Office Office NNP cord-010092-uftc8inx 3729 8 ( ( -LRB- cord-010092-uftc8inx 3729 9 EMRO EMRO NNP cord-010092-uftc8inx 3729 10 ) ) -RRB- cord-010092-uftc8inx 3729 11 supporting support VBG cord-010092-uftc8inx 3729 12 8 8 CD cord-010092-uftc8inx 3729 13 Arabic arabic JJ cord-010092-uftc8inx 3729 14 speaking speaking NN cord-010092-uftc8inx 3729 15 countries country NNS cord-010092-uftc8inx 3729 16 and and CC cord-010092-uftc8inx 3729 17 the the DT cord-010092-uftc8inx 3729 18 African African NNP cord-010092-uftc8inx 3729 19 Regional Regional NNP cord-010092-uftc8inx 3729 20 Office Office NNP cord-010092-uftc8inx 3729 21 ( ( -LRB- cord-010092-uftc8inx 3729 22 AFRO AFRO NNP cord-010092-uftc8inx 3729 23 ) ) -RRB- cord-010092-uftc8inx 3729 24 responsible responsible JJ cord-010092-uftc8inx 3729 25 for for IN cord-010092-uftc8inx 3729 26 47 47 CD cord-010092-uftc8inx 3729 27 Sub Sub NNP cord-010092-uftc8inx 3729 28 - - HYPH cord-010092-uftc8inx 3729 29 Saharan Saharan NNP cord-010092-uftc8inx 3729 30 Countries Countries NNPS cord-010092-uftc8inx 3729 31 . . . cord-010092-uftc8inx 3730 1 Population population NN cord-010092-uftc8inx 3730 2 distribution distribution NN cord-010092-uftc8inx 3730 3 is be VBZ cord-010092-uftc8inx 3730 4 approximately approximately RB cord-010092-uftc8inx 3730 5 40.6 40.6 CD cord-010092-uftc8inx 3730 6 % % NN cord-010092-uftc8inx 3730 7 urban urban JJ cord-010092-uftc8inx 3730 8 . . . cord-010092-uftc8inx 3731 1 There there EX cord-010092-uftc8inx 3731 2 are be VBP cord-010092-uftc8inx 3731 3 a a DT cord-010092-uftc8inx 3731 4 large large JJ cord-010092-uftc8inx 3731 5 number number NN cord-010092-uftc8inx 3731 6 of of IN cord-010092-uftc8inx 3731 7 different different JJ cord-010092-uftc8inx 3731 8 local local JJ cord-010092-uftc8inx 3731 9 dialects dialect NNS cord-010092-uftc8inx 3731 10 and and CC cord-010092-uftc8inx 3731 11 languages language NNS cord-010092-uftc8inx 3731 12 spoken speak VBN cord-010092-uftc8inx 3731 13 . . . cord-010092-uftc8inx 3732 1 The the DT cord-010092-uftc8inx 3732 2 main main JJ cord-010092-uftc8inx 3732 3 languages language NNS cord-010092-uftc8inx 3732 4 spoken speak VBN cord-010092-uftc8inx 3732 5 are be VBP cord-010092-uftc8inx 3732 6 English English NNP cord-010092-uftc8inx 3732 7 , , , cord-010092-uftc8inx 3732 8 French french JJ cord-010092-uftc8inx 3732 9 , , , cord-010092-uftc8inx 3732 10 Portuguese portuguese JJ cord-010092-uftc8inx 3732 11 , , , cord-010092-uftc8inx 3732 12 Spanish spanish JJ cord-010092-uftc8inx 3732 13 and and CC cord-010092-uftc8inx 3732 14 Arabic arabic JJ cord-010092-uftc8inx 3732 15 . . . cord-010092-uftc8inx 3733 1 Countries country NNS cord-010092-uftc8inx 3733 2 are be VBP cord-010092-uftc8inx 3733 3 mainly mainly RB cord-010092-uftc8inx 3733 4 classified classify VBN cord-010092-uftc8inx 3733 5 by by IN cord-010092-uftc8inx 3733 6 UNDP UNDP NNP cord-010092-uftc8inx 3733 7 as as IN cord-010092-uftc8inx 3733 8 being be VBG cord-010092-uftc8inx 3733 9 of of IN cord-010092-uftc8inx 3733 10 low low JJ cord-010092-uftc8inx 3733 11 and and CC cord-010092-uftc8inx 3733 12 medium medium JJ cord-010092-uftc8inx 3733 13 Human Human NNP cord-010092-uftc8inx 3733 14 Development Development NNP cord-010092-uftc8inx 3733 15 Index Index NNP cord-010092-uftc8inx 3734 1 The the DT cord-010092-uftc8inx 3734 2 Africa Africa NNP cord-010092-uftc8inx 3734 3 Society Society NNP cord-010092-uftc8inx 3734 4 for for IN cord-010092-uftc8inx 3734 5 Blood Blood NNP cord-010092-uftc8inx 3734 6 Transfusion Transfusion NNP cord-010092-uftc8inx 3735 1 ( ( -LRB- cord-010092-uftc8inx 3735 2 AfSBT AfSBT NNP cord-010092-uftc8inx 3735 3 ) ) -RRB- cord-010092-uftc8inx 3735 4 has have VBZ cord-010092-uftc8inx 3735 5 Members member NNS cord-010092-uftc8inx 3735 6 in in IN cord-010092-uftc8inx 3735 7 most most JJS cord-010092-uftc8inx 3735 8 countries country NNS cord-010092-uftc8inx 3735 9 , , , cord-010092-uftc8inx 3735 10 advocates advocate NNS cord-010092-uftc8inx 3735 11 for for IN cord-010092-uftc8inx 3735 12 the the DT cord-010092-uftc8inx 3735 13 development development NN cord-010092-uftc8inx 3735 14 of of IN cord-010092-uftc8inx 3735 15 sustainable sustainable JJ cord-010092-uftc8inx 3735 16 and and CC cord-010092-uftc8inx 3735 17 effective effective JJ cord-010092-uftc8inx 3735 18 blood blood NN cord-010092-uftc8inx 3735 19 services service NNS cord-010092-uftc8inx 3735 20 , , , cord-010092-uftc8inx 3735 21 and and CC cord-010092-uftc8inx 3735 22 has have VBZ cord-010092-uftc8inx 3735 23 developed develop VBN cord-010092-uftc8inx 3735 24 a a DT cord-010092-uftc8inx 3735 25 stepwise stepwise JJ cord-010092-uftc8inx 3735 26 3 3 CD cord-010092-uftc8inx 3735 27 level level NN cord-010092-uftc8inx 3735 28 accreditation accreditation NN cord-010092-uftc8inx 3735 29 program program NN cord-010092-uftc8inx 3735 30 . . . cord-010092-uftc8inx 3736 1 In in IN cord-010092-uftc8inx 3736 2 2016 2016 CD cord-010092-uftc8inx 3736 3 EMRO EMRO NNP cord-010092-uftc8inx 3736 4 held hold VBD cord-010092-uftc8inx 3736 5 a a DT cord-010092-uftc8inx 3736 6 consensus consensus NN cord-010092-uftc8inx 3736 7 meeting meeting NN cord-010092-uftc8inx 3736 8 developing develop VBG cord-010092-uftc8inx 3736 9 a a DT cord-010092-uftc8inx 3736 10 " " `` cord-010092-uftc8inx 3736 11 Strategic Strategic NNP cord-010092-uftc8inx 3736 12 Framework Framework NNP cord-010092-uftc8inx 3736 13 for for IN cord-010092-uftc8inx 3736 14 Blood Blood NNP cord-010092-uftc8inx 3736 15 Safety Safety NNP cord-010092-uftc8inx 3736 16 and and CC cord-010092-uftc8inx 3736 17 Availability availability NN cord-010092-uftc8inx 3736 18 for for IN cord-010092-uftc8inx 3736 19 2016 2016 CD cord-010092-uftc8inx 3736 20 - - SYM cord-010092-uftc8inx 3736 21 2025 2025 CD cord-010092-uftc8inx 3736 22 " " '' cord-010092-uftc8inx 3736 23 with with IN cord-010092-uftc8inx 3736 24 a a DT cord-010092-uftc8inx 3736 25 set set NN cord-010092-uftc8inx 3736 26 of of IN cord-010092-uftc8inx 3736 27 priority priority NN cord-010092-uftc8inx 3736 28 interventions intervention NNS cord-010092-uftc8inx 3736 29 focusing focus VBG cord-010092-uftc8inx 3736 30 on on IN cord-010092-uftc8inx 3736 31 Leadership Leadership NNP cord-010092-uftc8inx 3736 32 and and CC cord-010092-uftc8inx 3736 33 Governance Governance NNP cord-010092-uftc8inx 3736 34 , , , cord-010092-uftc8inx 3736 35 Cooperation Cooperation NNP cord-010092-uftc8inx 3736 36 and and CC cord-010092-uftc8inx 3736 37 Collaboration Collaboration NNP cord-010092-uftc8inx 3736 38 , , , cord-010092-uftc8inx 3736 39 Provision Provision NNP cord-010092-uftc8inx 3736 40 of of IN cord-010092-uftc8inx 3736 41 Safe Safe NNP cord-010092-uftc8inx 3736 42 Blood Blood NNP cord-010092-uftc8inx 3736 43 and and CC cord-010092-uftc8inx 3736 44 Blood blood NN cord-010092-uftc8inx 3736 45 Products product NNS cord-010092-uftc8inx 3736 46 , , , cord-010092-uftc8inx 3736 47 Appropriate Appropriate NNP cord-010092-uftc8inx 3736 48 Clinical clinical JJ cord-010092-uftc8inx 3736 49 Use use NN cord-010092-uftc8inx 3736 50 of of IN cord-010092-uftc8inx 3736 51 Blood blood NN cord-010092-uftc8inx 3736 52 , , , cord-010092-uftc8inx 3736 53 and and CC cord-010092-uftc8inx 3736 54 Quality Quality NNP cord-010092-uftc8inx 3736 55 System System NNP cord-010092-uftc8inx 3736 56 Management Management NNP cord-010092-uftc8inx 3736 57 . . . cord-010092-uftc8inx 3737 1 In in IN cord-010092-uftc8inx 3737 2 2001 2001 CD cord-010092-uftc8inx 3737 3 all all DT cord-010092-uftc8inx 3737 4 54 54 CD cord-010092-uftc8inx 3737 5 Member Member NNP cord-010092-uftc8inx 3737 6 States States NNPS cord-010092-uftc8inx 3737 7 of of IN cord-010092-uftc8inx 3737 8 the the DT cord-010092-uftc8inx 3737 9 African African NNP cord-010092-uftc8inx 3737 10 Union Union NNP cord-010092-uftc8inx 3737 11 ( ( -LRB- cord-010092-uftc8inx 3737 12 AU AU NNP cord-010092-uftc8inx 3737 13 ) ) -RRB- cord-010092-uftc8inx 3737 14 countries country NNS cord-010092-uftc8inx 3737 15 , , , cord-010092-uftc8inx 3737 16 in in IN cord-010092-uftc8inx 3737 17 Abuja Abuja NNP cord-010092-uftc8inx 3737 18 , , , cord-010092-uftc8inx 3737 19 Nigeria Nigeria NNP cord-010092-uftc8inx 3737 20 , , , cord-010092-uftc8inx 3737 21 pledged pledge VBD cord-010092-uftc8inx 3737 22 that that IN cord-010092-uftc8inx 3737 23 national national JJ cord-010092-uftc8inx 3737 24 budget budget NN cord-010092-uftc8inx 3737 25 for for IN cord-010092-uftc8inx 3737 26 Health Health NNP cord-010092-uftc8inx 3737 27 should should MD cord-010092-uftc8inx 3737 28 be be VB cord-010092-uftc8inx 3737 29 at at RB cord-010092-uftc8inx 3737 30 least least RBS cord-010092-uftc8inx 3737 31 15 15 CD cord-010092-uftc8inx 3737 32 % % NN cord-010092-uftc8inx 3737 33 of of IN cord-010092-uftc8inx 3737 34 the the DT cord-010092-uftc8inx 3737 35 National National NNP cord-010092-uftc8inx 3737 36 Fiscal Fiscal NNP cord-010092-uftc8inx 3737 37 Budget Budget NNP cord-010092-uftc8inx 3737 38 . . . cord-010092-uftc8inx 3738 1 In in IN cord-010092-uftc8inx 3738 2 2013 2013 CD cord-010092-uftc8inx 3738 3 Ministers Ministers NNPS cord-010092-uftc8inx 3738 4 of of IN cord-010092-uftc8inx 3738 5 Health Health NNP cord-010092-uftc8inx 3738 6 of of IN cord-010092-uftc8inx 3738 7 WHO WHO NNP cord-010092-uftc8inx 3738 8 Member Member NNP cord-010092-uftc8inx 3738 9 States States NNP cord-010092-uftc8inx 3738 10 endorsed endorse VBD cord-010092-uftc8inx 3738 11 that that DT cord-010092-uftc8inx 3738 12 blood blood NN cord-010092-uftc8inx 3738 13 and and CC cord-010092-uftc8inx 3738 14 blood blood NN cord-010092-uftc8inx 3738 15 products product NNS cord-010092-uftc8inx 3738 16 be be VB cord-010092-uftc8inx 3738 17 included include VBN cord-010092-uftc8inx 3738 18 in in IN cord-010092-uftc8inx 3738 19 the the DT cord-010092-uftc8inx 3738 20 Essential Essential NNP cord-010092-uftc8inx 3738 21 Medicines Medicines NNPS cord-010092-uftc8inx 3738 22 List List NNP cord-010092-uftc8inx 3738 23 ; ; : cord-010092-uftc8inx 3738 24 these these DT cord-010092-uftc8inx 3738 25 endorsements endorsement NNS cord-010092-uftc8inx 3738 26 and and CC cord-010092-uftc8inx 3738 27 WHO who WP cord-010092-uftc8inx 3738 28 's be VBZ cord-010092-uftc8inx 3738 29 Universal Universal NNP cord-010092-uftc8inx 3738 30 Health Health NNP cord-010092-uftc8inx 3738 31 Coverage Coverage NNP cord-010092-uftc8inx 3738 32 ( ( -LRB- cord-010092-uftc8inx 3738 33 UHC UHC NNP cord-010092-uftc8inx 3738 34 ) ) -RRB- cord-010092-uftc8inx 3738 35 , , , cord-010092-uftc8inx 3738 36 have have VBP cord-010092-uftc8inx 3738 37 yet yet RB cord-010092-uftc8inx 3738 38 to to TO cord-010092-uftc8inx 3738 39 be be VB cord-010092-uftc8inx 3738 40 fully fully RB cord-010092-uftc8inx 3738 41 implemented implement VBN cord-010092-uftc8inx 3738 42 . . . cord-010092-uftc8inx 3739 1 Aims aim VBZ cord-010092-uftc8inx 3739 2 : : : cord-010092-uftc8inx 3740 1 To to TO cord-010092-uftc8inx 3740 2 analyze analyze VB cord-010092-uftc8inx 3740 3 ( ( -LRB- cord-010092-uftc8inx 3740 4 gap gap NN cord-010092-uftc8inx 3740 5 - - HYPH cord-010092-uftc8inx 3740 6 analysis analysis NN cord-010092-uftc8inx 3740 7 ) ) -RRB- cord-010092-uftc8inx 3740 8 to to TO cord-010092-uftc8inx 3740 9 what what WP cord-010092-uftc8inx 3740 10 extend extend VB cord-010092-uftc8inx 3740 11 countries country NNS cord-010092-uftc8inx 3740 12 in in IN cord-010092-uftc8inx 3740 13 Africa Africa NNP cord-010092-uftc8inx 3740 14 implement implement VB cord-010092-uftc8inx 3740 15 the the DT cord-010092-uftc8inx 3740 16 World World NNP cord-010092-uftc8inx 3740 17 Health Health NNP cord-010092-uftc8inx 3740 18 Assembly Assembly NNP cord-010092-uftc8inx 3740 19 Resolution Resolution NNP cord-010092-uftc8inx 3740 20 WHA63.12 WHA63.12 NNP cord-010092-uftc8inx 3740 21 on on IN cord-010092-uftc8inx 3740 22 Availability availability NN cord-010092-uftc8inx 3740 23 , , , cord-010092-uftc8inx 3740 24 Safety Safety NNP cord-010092-uftc8inx 3740 25 and and CC cord-010092-uftc8inx 3740 26 Quality Quality NNP cord-010092-uftc8inx 3740 27 of of IN cord-010092-uftc8inx 3740 28 Blood Blood NNP cord-010092-uftc8inx 3740 29 Products Products NNPS cord-010092-uftc8inx 3740 30 , , , cord-010092-uftc8inx 3740 31 which which WDT cord-010092-uftc8inx 3740 32 urges urge VBZ cord-010092-uftc8inx 3740 33 governments government NNS cord-010092-uftc8inx 3740 34 to to TO cord-010092-uftc8inx 3740 35 ensure ensure VB cord-010092-uftc8inx 3740 36 safe safe JJ cord-010092-uftc8inx 3740 37 , , , cord-010092-uftc8inx 3740 38 accessible accessible JJ cord-010092-uftc8inx 3740 39 , , , cord-010092-uftc8inx 3740 40 affordable affordable JJ cord-010092-uftc8inx 3740 41 and and CC cord-010092-uftc8inx 3740 42 available available JJ cord-010092-uftc8inx 3740 43 supplies supply NNS cord-010092-uftc8inx 3740 44 of of IN cord-010092-uftc8inx 3740 45 blood blood NN cord-010092-uftc8inx 3740 46 and and CC cord-010092-uftc8inx 3740 47 components component NNS cord-010092-uftc8inx 3740 48 from from IN cord-010092-uftc8inx 3740 49 voluntary voluntary JJ cord-010092-uftc8inx 3740 50 non non JJ cord-010092-uftc8inx 3740 51 - - JJ cord-010092-uftc8inx 3740 52 remunerated remunerated JJ cord-010092-uftc8inx 3740 53 blood blood NN cord-010092-uftc8inx 3740 54 donors donor NNS cord-010092-uftc8inx 3740 55 , , , cord-010092-uftc8inx 3740 56 which which WDT cord-010092-uftc8inx 3740 57 meet meet VBP cord-010092-uftc8inx 3740 58 clinical clinical JJ cord-010092-uftc8inx 3740 59 transfusion transfusion NN cord-010092-uftc8inx 3740 60 requirements requirement NNS cord-010092-uftc8inx 3740 61 and and CC cord-010092-uftc8inx 3740 62 achieve achieve VB cord-010092-uftc8inx 3740 63 national national JJ cord-010092-uftc8inx 3740 64 self self NN cord-010092-uftc8inx 3740 65 - - HYPH cord-010092-uftc8inx 3740 66 sufficiency sufficiency NN cord-010092-uftc8inx 3740 67 , , , cord-010092-uftc8inx 3740 68 following follow VBG cord-010092-uftc8inx 3740 69 WHO who WP cord-010092-uftc8inx 3740 70 guidelines guideline NNS cord-010092-uftc8inx 3740 71 and and CC cord-010092-uftc8inx 3740 72 recommendations recommendation NNS cord-010092-uftc8inx 3740 73 . . . cord-010092-uftc8inx 3741 1 Methods method NNS cord-010092-uftc8inx 3741 2 : : : cord-010092-uftc8inx 3741 3 To to TO cord-010092-uftc8inx 3741 4 provide provide VB cord-010092-uftc8inx 3741 5 an an DT cord-010092-uftc8inx 3741 6 overview overview NN cord-010092-uftc8inx 3741 7 of of IN cord-010092-uftc8inx 3741 8 the the DT cord-010092-uftc8inx 3741 9 current current JJ cord-010092-uftc8inx 3741 10 status status NN cord-010092-uftc8inx 3741 11 of of IN cord-010092-uftc8inx 3741 12 the the DT cord-010092-uftc8inx 3741 13 blood blood NN cord-010092-uftc8inx 3741 14 supply supply NN cord-010092-uftc8inx 3741 15 in in IN cord-010092-uftc8inx 3741 16 Africa Africa NNP cord-010092-uftc8inx 3741 17 strengths strength NNS cord-010092-uftc8inx 3741 18 and and CC cord-010092-uftc8inx 3741 19 weaknesses weakness NNS cord-010092-uftc8inx 3741 20 , , , cord-010092-uftc8inx 3741 21 data datum NNS cord-010092-uftc8inx 3741 22 from from IN cord-010092-uftc8inx 3741 23 WHO who WP cord-010092-uftc8inx 3741 24 's 's POS cord-010092-uftc8inx 3741 25 2016 2016 CD cord-010092-uftc8inx 3741 26 Global Global NNP cord-010092-uftc8inx 3741 27 Status Status NNP cord-010092-uftc8inx 3741 28 Report Report NNP cord-010092-uftc8inx 3741 29 on on IN cord-010092-uftc8inx 3741 30 Blood Blood NNP cord-010092-uftc8inx 3741 31 Safety Safety NNP cord-010092-uftc8inx 3741 32 and and CC cord-010092-uftc8inx 3741 33 Availability availability NN cord-010092-uftc8inx 3741 34 were be VBD cord-010092-uftc8inx 3741 35 analyzed analyze VBN cord-010092-uftc8inx 3741 36 and and CC cord-010092-uftc8inx 3741 37 used use VBN cord-010092-uftc8inx 3741 38 . . . cord-010092-uftc8inx 3742 1 The the DT cord-010092-uftc8inx 3742 2 study study NN cord-010092-uftc8inx 3742 3 has have VBZ cord-010092-uftc8inx 3742 4 been be VBN cord-010092-uftc8inx 3742 5 descriptive descriptive JJ cord-010092-uftc8inx 3742 6 and and CC cord-010092-uftc8inx 3742 7 explorative explorative JJ cord-010092-uftc8inx 3742 8 . . . cord-010092-uftc8inx 3743 1 Results result NNS cord-010092-uftc8inx 3743 2 : : : cord-010092-uftc8inx 3744 1 The the DT cord-010092-uftc8inx 3744 2 2016 2016 CD cord-010092-uftc8inx 3744 3 Report Report NNP cord-010092-uftc8inx 3744 4 identified identify VBD cord-010092-uftc8inx 3744 5 a a DT cord-010092-uftc8inx 3744 6 number number NN cord-010092-uftc8inx 3744 7 of of IN cord-010092-uftc8inx 3744 8 areas area NNS cord-010092-uftc8inx 3744 9 requiring require VBG cord-010092-uftc8inx 3744 10 attention attention NN cord-010092-uftc8inx 3744 11 ; ; : cord-010092-uftc8inx 3744 12 principle principle NN cord-010092-uftc8inx 3744 13 amongst amongst IN cord-010092-uftc8inx 3744 14 these these DT cord-010092-uftc8inx 3744 15 were be VBD cord-010092-uftc8inx 3744 16 -inadequate -inadequate JJ cord-010092-uftc8inx 3744 17 funding funding NN cord-010092-uftc8inx 3744 18 ; ; : cord-010092-uftc8inx 3744 19 -lack -lack , cord-010092-uftc8inx 3744 20 of of IN cord-010092-uftc8inx 3744 21 governance governance NN cord-010092-uftc8inx 3744 22 and and CC cord-010092-uftc8inx 3744 23 leadership leadership NN cord-010092-uftc8inx 3744 24 ; ; : cord-010092-uftc8inx 3744 25 -ineffective -ineffective JJ cord-010092-uftc8inx 3744 26 public public JJ cord-010092-uftc8inx 3744 27 education education NN cord-010092-uftc8inx 3744 28 on on IN cord-010092-uftc8inx 3744 29 blood blood NN cord-010092-uftc8inx 3744 30 donation donation NN cord-010092-uftc8inx 3744 31 ; ; : cord-010092-uftc8inx 3744 32 -absence -absence NN cord-010092-uftc8inx 3744 33 of of IN cord-010092-uftc8inx 3744 34 capacity capacity NN cord-010092-uftc8inx 3744 35 building building NN cord-010092-uftc8inx 3744 36 for for IN cord-010092-uftc8inx 3744 37 clinicians clinician NNS cord-010092-uftc8inx 3744 38 on on IN cord-010092-uftc8inx 3744 39 rational rational JJ cord-010092-uftc8inx 3744 40 use use NN cord-010092-uftc8inx 3744 41 of of IN cord-010092-uftc8inx 3744 42 blood blood NN cord-010092-uftc8inx 3744 43 ; ; . cord-010092-uftc8inx 3745 1 -lack -lack NN cord-010092-uftc8inx 3745 2 of of IN cord-010092-uftc8inx 3745 3 Haemovigilance Haemovigilance NNP cord-010092-uftc8inx 3745 4 and and CC cord-010092-uftc8inx 3745 5 implementation implementation NN cord-010092-uftc8inx 3745 6 of of IN cord-010092-uftc8inx 3745 7 quality quality NN cord-010092-uftc8inx 3745 8 management management NN cord-010092-uftc8inx 3745 9 systems system NNS cord-010092-uftc8inx 3745 10 ; ; : cord-010092-uftc8inx 3745 11 -the -the WDT cord-010092-uftc8inx 3745 12 need need NN cord-010092-uftc8inx 3745 13 for for IN cord-010092-uftc8inx 3745 14 regulatory regulatory JJ cord-010092-uftc8inx 3745 15 or or CC cord-010092-uftc8inx 3745 16 oversight oversight NN cord-010092-uftc8inx 3745 17 mechanisms mechanism NNS cord-010092-uftc8inx 3745 18 . . . cord-010092-uftc8inx 3746 1 Summary Summary NNP cord-010092-uftc8inx 3746 2 / / SYM cord-010092-uftc8inx 3746 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 3746 4 : : : cord-010092-uftc8inx 3747 1 National National NNP cord-010092-uftc8inx 3747 2 Authorities Authorities NNPS cord-010092-uftc8inx 3747 3 should should MD cord-010092-uftc8inx 3747 4 address address VB cord-010092-uftc8inx 3747 5 areas area NNS cord-010092-uftc8inx 3747 6 requiring require VBG cord-010092-uftc8inx 3747 7 attention attention NN cord-010092-uftc8inx 3747 8 if if IN cord-010092-uftc8inx 3747 9 progress progress NN cord-010092-uftc8inx 3747 10 towards towards IN cord-010092-uftc8inx 3747 11 ensuring ensure VBG cord-010092-uftc8inx 3747 12 a a DT cord-010092-uftc8inx 3747 13 sustainable sustainable JJ cord-010092-uftc8inx 3747 14 safe safe JJ cord-010092-uftc8inx 3747 15 and and CC cord-010092-uftc8inx 3747 16 sufficient sufficient JJ cord-010092-uftc8inx 3747 17 supply supply NN cord-010092-uftc8inx 3747 18 of of IN cord-010092-uftc8inx 3747 19 blood blood NN cord-010092-uftc8inx 3747 20 products product NNS cord-010092-uftc8inx 3747 21 is be VBZ cord-010092-uftc8inx 3747 22 to to TO cord-010092-uftc8inx 3747 23 be be VB cord-010092-uftc8inx 3747 24 achieved achieve VBN cord-010092-uftc8inx 3747 25 . . . cord-010092-uftc8inx 3748 1 Key key JJ cord-010092-uftc8inx 3748 2 is be VBZ cord-010092-uftc8inx 3748 3 the the DT cord-010092-uftc8inx 3748 4 commitment commitment NN cord-010092-uftc8inx 3748 5 and and CC cord-010092-uftc8inx 3748 6 support support NN cord-010092-uftc8inx 3748 7 of of IN cord-010092-uftc8inx 3748 8 National National NNP cord-010092-uftc8inx 3748 9 Governments Governments NNPS cord-010092-uftc8inx 3748 10 , , , cord-010092-uftc8inx 3748 11 which which WDT cord-010092-uftc8inx 3748 12 should should MD cord-010092-uftc8inx 3748 13 implement implement VB cord-010092-uftc8inx 3748 14 Resolutions Resolutions NNPS cord-010092-uftc8inx 3748 15 and and CC cord-010092-uftc8inx 3748 16 Recommendations Recommendations NNPS cord-010092-uftc8inx 3748 17 agreed agree VBD cord-010092-uftc8inx 3748 18 by by IN cord-010092-uftc8inx 3748 19 Ministers Ministers NNPS cord-010092-uftc8inx 3748 20 of of IN cord-010092-uftc8inx 3748 21 Health Health NNP cord-010092-uftc8inx 3748 22 at at IN cord-010092-uftc8inx 3748 23 WHA WHA NNP cord-010092-uftc8inx 3748 24 and and CC cord-010092-uftc8inx 3748 25 African African NNP cord-010092-uftc8inx 3748 26 Union Union NNP cord-010092-uftc8inx 3748 27 . . . cord-010092-uftc8inx 3749 1 Background background NN cord-010092-uftc8inx 3749 2 : : : cord-010092-uftc8inx 3750 1 The the DT cord-010092-uftc8inx 3750 2 core core NN cord-010092-uftc8inx 3750 3 function function NN cord-010092-uftc8inx 3750 4 of of IN cord-010092-uftc8inx 3750 5 the the DT cord-010092-uftc8inx 3750 6 Blood Blood NNP cord-010092-uftc8inx 3750 7 Donation Donation NNP cord-010092-uftc8inx 3750 8 Testing Testing NNP cord-010092-uftc8inx 3750 9 ( ( -LRB- cord-010092-uftc8inx 3750 10 BDT BDT NNP cord-010092-uftc8inx 3750 11 ) ) -RRB- cord-010092-uftc8inx 3750 12 Laboratory laboratory NN cord-010092-uftc8inx 3750 13 is be VBZ cord-010092-uftc8inx 3750 14 to to TO cord-010092-uftc8inx 3750 15 screen screen VB cord-010092-uftc8inx 3750 16 every every DT cord-010092-uftc8inx 3750 17 unit unit NN cord-010092-uftc8inx 3750 18 of of IN cord-010092-uftc8inx 3750 19 blood blood NN cord-010092-uftc8inx 3750 20 collected collect VBN cord-010092-uftc8inx 3750 21 from from IN cord-010092-uftc8inx 3750 22 a a DT cord-010092-uftc8inx 3750 23 donor donor NN cord-010092-uftc8inx 3750 24 for for IN cord-010092-uftc8inx 3750 25 blood blood NN cord-010092-uftc8inx 3750 26 group group NN cord-010092-uftc8inx 3750 27 type type NN cord-010092-uftc8inx 3750 28 and and CC cord-010092-uftc8inx 3750 29 infectious infectious JJ cord-010092-uftc8inx 3750 30 disease disease NN cord-010092-uftc8inx 3750 31 markers marker NNS cord-010092-uftc8inx 3750 32 to to TO cord-010092-uftc8inx 3750 33 ensure ensure VB cord-010092-uftc8inx 3750 34 safety safety NN cord-010092-uftc8inx 3750 35 of of IN cord-010092-uftc8inx 3750 36 the the DT cord-010092-uftc8inx 3750 37 national national JJ cord-010092-uftc8inx 3750 38 blood blood NN cord-010092-uftc8inx 3750 39 supply supply NN cord-010092-uftc8inx 3750 40 prior prior RB cord-010092-uftc8inx 3750 41 to to IN cord-010092-uftc8inx 3750 42 transfusion transfusion NN cord-010092-uftc8inx 3750 43 . . . cord-010092-uftc8inx 3751 1 The the DT cord-010092-uftc8inx 3751 2 lab lab NN cord-010092-uftc8inx 3751 3 operates operate VBZ cord-010092-uftc8inx 3751 4 daily daily RB cord-010092-uftc8inx 3751 5 on on IN cord-010092-uftc8inx 3751 6 two two CD cord-010092-uftc8inx 3751 7 work work NN cord-010092-uftc8inx 3751 8 shifts shift NNS cord-010092-uftc8inx 3751 9 , , , cord-010092-uftc8inx 3751 10 comprising comprise VBG cord-010092-uftc8inx 3751 11 of of IN cord-010092-uftc8inx 3751 12 4 4 CD cord-010092-uftc8inx 3751 13 staff staff NN cord-010092-uftc8inx 3751 14 on on IN cord-010092-uftc8inx 3751 15 the the DT cord-010092-uftc8inx 3751 16 morning morning NN cord-010092-uftc8inx 3751 17 ( ( -LRB- cord-010092-uftc8inx 3751 18 AM AM NNP cord-010092-uftc8inx 3751 19 ) ) -RRB- cord-010092-uftc8inx 3751 20 shift shift NN cord-010092-uftc8inx 3751 21 ( ( -LRB- cord-010092-uftc8inx 3751 22 from from IN cord-010092-uftc8inx 3751 23 8:00 8:00 CD cord-010092-uftc8inx 3751 24 to to IN cord-010092-uftc8inx 3751 25 17:30 17:30 CD cord-010092-uftc8inx 3751 26 ) ) -RRB- cord-010092-uftc8inx 3751 27 and and CC cord-010092-uftc8inx 3751 28 5 5 CD cord-010092-uftc8inx 3751 29 staff staff NN cord-010092-uftc8inx 3751 30 on on IN cord-010092-uftc8inx 3751 31 the the DT cord-010092-uftc8inx 3751 32 afternoon afternoon NN cord-010092-uftc8inx 3751 33 ( ( -LRB- cord-010092-uftc8inx 3751 34 PM PM NNP cord-010092-uftc8inx 3751 35 ) ) -RRB- cord-010092-uftc8inx 3751 36 shift shift NN cord-010092-uftc8inx 3751 37 ( ( -LRB- cord-010092-uftc8inx 3751 38 from from IN cord-010092-uftc8inx 3751 39 13:00 13:00 CD cord-010092-uftc8inx 3751 40 to to IN cord-010092-uftc8inx 3751 41 22:00 22:00 CD cord-010092-uftc8inx 3751 42 ) ) -RRB- cord-010092-uftc8inx 3751 43 on on IN cord-010092-uftc8inx 3751 44 weekdays weekday NNS cord-010092-uftc8inx 3751 45 and and CC cord-010092-uftc8inx 3751 46 3 3 CD cord-010092-uftc8inx 3751 47 staff staff NN cord-010092-uftc8inx 3751 48 on on IN cord-010092-uftc8inx 3751 49 the the DT cord-010092-uftc8inx 3751 50 AM AM NNP cord-010092-uftc8inx 3751 51 shift shift NN cord-010092-uftc8inx 3751 52 and and CC cord-010092-uftc8inx 3751 53 5 5 CD cord-010092-uftc8inx 3751 54 staff staff NN cord-010092-uftc8inx 3751 55 on on IN cord-010092-uftc8inx 3751 56 the the DT cord-010092-uftc8inx 3751 57 PM PM NNP cord-010092-uftc8inx 3751 58 shift shift NN cord-010092-uftc8inx 3751 59 on on IN cord-010092-uftc8inx 3751 60 weekends weekend NNS cord-010092-uftc8inx 3751 61 . . . cord-010092-uftc8inx 3752 1 BDT BDT NNP cord-010092-uftc8inx 3752 2 Lab Lab NNP cord-010092-uftc8inx 3752 3 has have VBZ cord-010092-uftc8inx 3752 4 a a DT cord-010092-uftc8inx 3752 5 staff staff NN cord-010092-uftc8inx 3752 6 strength strength NN cord-010092-uftc8inx 3752 7 of of IN cord-010092-uftc8inx 3752 8 15 15 CD cord-010092-uftc8inx 3752 9 to to TO cord-010092-uftc8inx 3752 10 be be VB cord-010092-uftc8inx 3752 11 rostered rostere VBN cord-010092-uftc8inx 3752 12 for for IN cord-010092-uftc8inx 3752 13 the the DT cord-010092-uftc8inx 3752 14 2 2 CD cord-010092-uftc8inx 3752 15 work work NN cord-010092-uftc8inx 3752 16 shifts shift NNS cord-010092-uftc8inx 3752 17 . . . cord-010092-uftc8inx 3753 1 Each each DT cord-010092-uftc8inx 3753 2 staff staff NN cord-010092-uftc8inx 3753 3 is be VBZ cord-010092-uftc8inx 3753 4 on on IN cord-010092-uftc8inx 3753 5 a a DT cord-010092-uftc8inx 3753 6 five five CD cord-010092-uftc8inx 3753 7 - - HYPH cord-010092-uftc8inx 3753 8 day day NN cord-010092-uftc8inx 3753 9 work work NN cord-010092-uftc8inx 3753 10 week week NN cord-010092-uftc8inx 3753 11 and and CC cord-010092-uftc8inx 3753 12 has have VBZ cord-010092-uftc8inx 3753 13 to to TO cord-010092-uftc8inx 3753 14 work work VB cord-010092-uftc8inx 3753 15 11 11 CD cord-010092-uftc8inx 3753 16 PM pm NN cord-010092-uftc8inx 3753 17 shift shift NN cord-010092-uftc8inx 3753 18 and and CC cord-010092-uftc8inx 3753 19 9 9 CD cord-010092-uftc8inx 3753 20 AM am NN cord-010092-uftc8inx 3753 21 shift shift NN cord-010092-uftc8inx 3753 22 per per IN cord-010092-uftc8inx 3753 23 month month NN cord-010092-uftc8inx 3753 24 on on IN cord-010092-uftc8inx 3753 25 average average JJ cord-010092-uftc8inx 3753 26 . . . cord-010092-uftc8inx 3754 1 The the DT cord-010092-uftc8inx 3754 2 higher high JJR cord-010092-uftc8inx 3754 3 number number NN cord-010092-uftc8inx 3754 4 of of IN cord-010092-uftc8inx 3754 5 PM pm NN cord-010092-uftc8inx 3754 6 shift shift NN cord-010092-uftc8inx 3754 7 leads lead VBZ cord-010092-uftc8inx 3754 8 to to IN cord-010092-uftc8inx 3754 9 staff staff NN cord-010092-uftc8inx 3754 10 feedback feedback NN cord-010092-uftc8inx 3754 11 that that IN cord-010092-uftc8inx 3754 12 they -PRON- PRP cord-010092-uftc8inx 3754 13 do do VBP cord-010092-uftc8inx 3754 14 not not RB cord-010092-uftc8inx 3754 15 get get VB cord-010092-uftc8inx 3754 16 sufficient sufficient JJ cord-010092-uftc8inx 3754 17 time time NN cord-010092-uftc8inx 3754 18 in in IN cord-010092-uftc8inx 3754 19 the the DT cord-010092-uftc8inx 3754 20 evenings evening NNS cord-010092-uftc8inx 3754 21 for for IN cord-010092-uftc8inx 3754 22 family family NN cord-010092-uftc8inx 3754 23 and and CC cord-010092-uftc8inx 3754 24 social social JJ cord-010092-uftc8inx 3754 25 or or CC cord-010092-uftc8inx 3754 26 leisure leisure NN cord-010092-uftc8inx 3754 27 activities activity NNS cord-010092-uftc8inx 3754 28 . . . cord-010092-uftc8inx 3755 1 A a DT cord-010092-uftc8inx 3755 2 Lean Lean NNP cord-010092-uftc8inx 3755 3 Six six CD cord-010092-uftc8inx 3755 4 Sigma Sigma NNP cord-010092-uftc8inx 3755 5 project project NN cord-010092-uftc8inx 3755 6 was be VBD cord-010092-uftc8inx 3755 7 initiated initiate VBN cord-010092-uftc8inx 3755 8 to to TO cord-010092-uftc8inx 3755 9 review review VB cord-010092-uftc8inx 3755 10 the the DT cord-010092-uftc8inx 3755 11 work work NN cord-010092-uftc8inx 3755 12 rostering rostering NN cord-010092-uftc8inx 3755 13 to to TO cord-010092-uftc8inx 3755 14 improve improve VB cord-010092-uftc8inx 3755 15 the the DT cord-010092-uftc8inx 3755 16 work work NN cord-010092-uftc8inx 3755 17 - - HYPH cord-010092-uftc8inx 3755 18 life life NN cord-010092-uftc8inx 3755 19 balance balance NN cord-010092-uftc8inx 3755 20 of of IN cord-010092-uftc8inx 3755 21 the the DT cord-010092-uftc8inx 3755 22 staff staff NN cord-010092-uftc8inx 3755 23 . . . cord-010092-uftc8inx 3756 1 Aims aim VBZ cord-010092-uftc8inx 3756 2 : : : cord-010092-uftc8inx 3757 1 The the DT cord-010092-uftc8inx 3757 2 project project NN cord-010092-uftc8inx 3757 3 aims aim VBZ cord-010092-uftc8inx 3757 4 to to TO cord-010092-uftc8inx 3757 5 reduce reduce VB cord-010092-uftc8inx 3757 6 the the DT cord-010092-uftc8inx 3757 7 number number NN cord-010092-uftc8inx 3757 8 of of IN cord-010092-uftc8inx 3757 9 staff staff NN cord-010092-uftc8inx 3757 10 working work VBG cord-010092-uftc8inx 3757 11 on on IN cord-010092-uftc8inx 3757 12 the the DT cord-010092-uftc8inx 3757 13 PM PM NNP cord-010092-uftc8inx 3757 14 shift shift NN cord-010092-uftc8inx 3757 15 without without IN cord-010092-uftc8inx 3757 16 affecting affect VBG cord-010092-uftc8inx 3757 17 the the DT cord-010092-uftc8inx 3757 18 downstream downstream JJ cord-010092-uftc8inx 3757 19 processes process NNS cord-010092-uftc8inx 3757 20 and and CC cord-010092-uftc8inx 3757 21 continues continue VBZ cord-010092-uftc8inx 3757 22 to to TO cord-010092-uftc8inx 3757 23 meet meet VB cord-010092-uftc8inx 3757 24 the the DT cord-010092-uftc8inx 3757 25 timely timely JJ cord-010092-uftc8inx 3757 26 release release NN cord-010092-uftc8inx 3757 27 of of IN cord-010092-uftc8inx 3757 28 blood blood NN cord-010092-uftc8inx 3757 29 supply supply NN cord-010092-uftc8inx 3757 30 to to IN cord-010092-uftc8inx 3757 31 the the DT cord-010092-uftc8inx 3757 32 hospitals hospital NNS cord-010092-uftc8inx 3757 33 . . . cord-010092-uftc8inx 3758 1 Methods method NNS cord-010092-uftc8inx 3758 2 : : : cord-010092-uftc8inx 3759 1 Lean Lean NNP cord-010092-uftc8inx 3759 2 Six six CD cord-010092-uftc8inx 3759 3 Sigma Sigma NNP cord-010092-uftc8inx 3759 4 tools tool NNS cord-010092-uftc8inx 3759 5 were be VBD cord-010092-uftc8inx 3759 6 used use VBN cord-010092-uftc8inx 3759 7 to to TO cord-010092-uftc8inx 3759 8 study study VB cord-010092-uftc8inx 3759 9 the the DT cord-010092-uftc8inx 3759 10 BDT BDT NNP cord-010092-uftc8inx 3759 11 Lab Lab NNP cord-010092-uftc8inx 3759 12 workflow workflow NN cord-010092-uftc8inx 3759 13 process process NN cord-010092-uftc8inx 3759 14 and and CC cord-010092-uftc8inx 3759 15 to to TO cord-010092-uftc8inx 3759 16 identify identify VB cord-010092-uftc8inx 3759 17 factors factor NNS cord-010092-uftc8inx 3759 18 that that WDT cord-010092-uftc8inx 3759 19 contributes contribute VBZ cord-010092-uftc8inx 3759 20 to to IN cord-010092-uftc8inx 3759 21 the the DT cord-010092-uftc8inx 3759 22 higher high JJR cord-010092-uftc8inx 3759 23 number number NN cord-010092-uftc8inx 3759 24 of of IN cord-010092-uftc8inx 3759 25 PM pm NN cord-010092-uftc8inx 3759 26 shifts shift NNS cord-010092-uftc8inx 3759 27 that that IN cord-010092-uftc8inx 3759 28 the the DT cord-010092-uftc8inx 3759 29 staff staff NN cord-010092-uftc8inx 3759 30 has have VBZ cord-010092-uftc8inx 3759 31 to to TO cord-010092-uftc8inx 3759 32 take take VB cord-010092-uftc8inx 3759 33 on on RP cord-010092-uftc8inx 3759 34 . . . cord-010092-uftc8inx 3760 1 Data datum NNS cord-010092-uftc8inx 3760 2 on on IN cord-010092-uftc8inx 3760 3 the the DT cord-010092-uftc8inx 3760 4 turn turn NN cord-010092-uftc8inx 3760 5 - - HYPH cord-010092-uftc8inx 3760 6 around around RP cord-010092-uftc8inx 3760 7 time time NN cord-010092-uftc8inx 3760 8 and and CC cord-010092-uftc8inx 3760 9 the the DT cord-010092-uftc8inx 3760 10 man man NN cord-010092-uftc8inx 3760 11 - - HYPH cord-010092-uftc8inx 3760 12 effort effort NN cord-010092-uftc8inx 3760 13 required require VBN cord-010092-uftc8inx 3760 14 for for IN cord-010092-uftc8inx 3760 15 each each DT cord-010092-uftc8inx 3760 16 screening screening NN cord-010092-uftc8inx 3760 17 tests test NNS cord-010092-uftc8inx 3760 18 performed perform VBN cord-010092-uftc8inx 3760 19 was be VBD cord-010092-uftc8inx 3760 20 analyzed analyze VBN cord-010092-uftc8inx 3760 21 . . . cord-010092-uftc8inx 3761 1 A a DT cord-010092-uftc8inx 3761 2 survey survey NN cord-010092-uftc8inx 3761 3 was be VBD cord-010092-uftc8inx 3761 4 also also RB cord-010092-uftc8inx 3761 5 conducted conduct VBN cord-010092-uftc8inx 3761 6 to to TO cord-010092-uftc8inx 3761 7 understand understand VB cord-010092-uftc8inx 3761 8 the the DT cord-010092-uftc8inx 3761 9 preference preference NN cord-010092-uftc8inx 3761 10 of of IN cord-010092-uftc8inx 3761 11 the the DT cord-010092-uftc8inx 3761 12 staff staff NN cord-010092-uftc8inx 3761 13 on on IN cord-010092-uftc8inx 3761 14 the the DT cord-010092-uftc8inx 3761 15 acceptable acceptable JJ cord-010092-uftc8inx 3761 16 number number NN cord-010092-uftc8inx 3761 17 of of IN cord-010092-uftc8inx 3761 18 PM pm NN cord-010092-uftc8inx 3761 19 shifts shift NNS cord-010092-uftc8inx 3761 20 per per IN cord-010092-uftc8inx 3761 21 month month NN cord-010092-uftc8inx 3761 22 . . . cord-010092-uftc8inx 3762 1 Results result NNS cord-010092-uftc8inx 3762 2 : : : cord-010092-uftc8inx 3763 1 The the DT cord-010092-uftc8inx 3763 2 main main JJ cord-010092-uftc8inx 3763 3 contributing contributing NN cord-010092-uftc8inx 3763 4 factor factor NN cord-010092-uftc8inx 3763 5 for for IN cord-010092-uftc8inx 3763 6 more more JJR cord-010092-uftc8inx 3763 7 staff staff NN cord-010092-uftc8inx 3763 8 required require VBN cord-010092-uftc8inx 3763 9 to to TO cord-010092-uftc8inx 3763 10 perform perform VB cord-010092-uftc8inx 3763 11 the the DT cord-010092-uftc8inx 3763 12 PM PM NNP cord-010092-uftc8inx 3763 13 shift shift NN cord-010092-uftc8inx 3763 14 is be VBZ cord-010092-uftc8inx 3763 15 due due JJ cord-010092-uftc8inx 3763 16 to to IN cord-010092-uftc8inx 3763 17 majority majority NN cord-010092-uftc8inx 3763 18 of of IN cord-010092-uftc8inx 3763 19 the the DT cord-010092-uftc8inx 3763 20 daily daily JJ cord-010092-uftc8inx 3763 21 donation donation NN cord-010092-uftc8inx 3763 22 samples sample NNS cord-010092-uftc8inx 3763 23 being be VBG cord-010092-uftc8inx 3763 24 received receive VBN cord-010092-uftc8inx 3763 25 only only RB cord-010092-uftc8inx 3763 26 in in IN cord-010092-uftc8inx 3763 27 the the DT cord-010092-uftc8inx 3763 28 evening evening NN cord-010092-uftc8inx 3763 29 . . . cord-010092-uftc8inx 3764 1 As as IN cord-010092-uftc8inx 3764 2 this this DT cord-010092-uftc8inx 3764 3 factor factor NN cord-010092-uftc8inx 3764 4 is be VBZ cord-010092-uftc8inx 3764 5 beyond beyond IN cord-010092-uftc8inx 3764 6 the the DT cord-010092-uftc8inx 3764 7 control control NN cord-010092-uftc8inx 3764 8 of of IN cord-010092-uftc8inx 3764 9 the the DT cord-010092-uftc8inx 3764 10 BDT BDT NNP cord-010092-uftc8inx 3764 11 Lab Lab NNP cord-010092-uftc8inx 3764 12 , , , cord-010092-uftc8inx 3764 13 redeploying redeploy VBG cord-010092-uftc8inx 3764 14 work work NN cord-010092-uftc8inx 3764 15 from from IN cord-010092-uftc8inx 3764 16 the the DT cord-010092-uftc8inx 3764 17 PM PM NNP cord-010092-uftc8inx 3764 18 shift shift NN cord-010092-uftc8inx 3764 19 to to IN cord-010092-uftc8inx 3764 20 the the DT cord-010092-uftc8inx 3764 21 AM AM NNP cord-010092-uftc8inx 3764 22 shift shift NN cord-010092-uftc8inx 3764 23 was be VBD cord-010092-uftc8inx 3764 24 eventually eventually RB cord-010092-uftc8inx 3764 25 selected select VBN cord-010092-uftc8inx 3764 26 as as IN cord-010092-uftc8inx 3764 27 the the DT cord-010092-uftc8inx 3764 28 solution solution NN cord-010092-uftc8inx 3764 29 to to TO cord-010092-uftc8inx 3764 30 reduce reduce VB cord-010092-uftc8inx 3764 31 the the DT cord-010092-uftc8inx 3764 32 number number NN cord-010092-uftc8inx 3764 33 of of IN cord-010092-uftc8inx 3764 34 staff staff NN cord-010092-uftc8inx 3764 35 needed need VBN cord-010092-uftc8inx 3764 36 for for IN cord-010092-uftc8inx 3764 37 the the DT cord-010092-uftc8inx 3764 38 PM PM NNP cord-010092-uftc8inx 3764 39 shift shift NN cord-010092-uftc8inx 3764 40 . . . cord-010092-uftc8inx 3765 1 The the DT cord-010092-uftc8inx 3765 2 screening screening NN cord-010092-uftc8inx 3765 3 test test NN cord-010092-uftc8inx 3765 4 that that WDT cord-010092-uftc8inx 3765 5 was be VBD cord-010092-uftc8inx 3765 6 shifted shift VBN cord-010092-uftc8inx 3765 7 was be VBD cord-010092-uftc8inx 3765 8 determined determine VBN cord-010092-uftc8inx 3765 9 based base VBN cord-010092-uftc8inx 3765 10 on on IN cord-010092-uftc8inx 3765 11 the the DT cord-010092-uftc8inx 3765 12 test test NN cord-010092-uftc8inx 3765 13 system system NN cord-010092-uftc8inx 3765 14 that that WDT cord-010092-uftc8inx 3765 15 has have VBZ cord-010092-uftc8inx 3765 16 the the DT cord-010092-uftc8inx 3765 17 shortest short JJS cord-010092-uftc8inx 3765 18 turn turn VB cord-010092-uftc8inx 3765 19 - - HYPH cord-010092-uftc8inx 3765 20 around around IN cord-010092-uftc8inx 3765 21 - - HYPH cord-010092-uftc8inx 3765 22 time time NN cord-010092-uftc8inx 3765 23 and and CC cord-010092-uftc8inx 3765 24 is be VBZ cord-010092-uftc8inx 3765 25 able able JJ cord-010092-uftc8inx 3765 26 to to TO cord-010092-uftc8inx 3765 27 allow allow VB cord-010092-uftc8inx 3765 28 continuous continuous JJ cord-010092-uftc8inx 3765 29 release release NN cord-010092-uftc8inx 3765 30 of of IN cord-010092-uftc8inx 3765 31 results result NNS cord-010092-uftc8inx 3765 32 . . . cord-010092-uftc8inx 3766 1 At at IN cord-010092-uftc8inx 3766 2 the the DT cord-010092-uftc8inx 3766 3 same same JJ cord-010092-uftc8inx 3766 4 time time NN cord-010092-uftc8inx 3766 5 , , , cord-010092-uftc8inx 3766 6 most most JJS cord-010092-uftc8inx 3766 7 of of IN cord-010092-uftc8inx 3766 8 the the DT cord-010092-uftc8inx 3766 9 staff staff NN cord-010092-uftc8inx 3766 10 must must MD cord-010092-uftc8inx 3766 11 be be VB cord-010092-uftc8inx 3766 12 trained train VBN cord-010092-uftc8inx 3766 13 for for IN cord-010092-uftc8inx 3766 14 that that DT cord-010092-uftc8inx 3766 15 test test NN cord-010092-uftc8inx 3766 16 system system NN cord-010092-uftc8inx 3766 17 . . . cord-010092-uftc8inx 3767 1 A a DT cord-010092-uftc8inx 3767 2 trial trial NN cord-010092-uftc8inx 3767 3 on on IN cord-010092-uftc8inx 3767 4 the the DT cord-010092-uftc8inx 3767 5 new new JJ cord-010092-uftc8inx 3767 6 roster roster NN cord-010092-uftc8inx 3767 7 involving involve VBG cord-010092-uftc8inx 3767 8 5 5 CD cord-010092-uftc8inx 3767 9 staff staff NN cord-010092-uftc8inx 3767 10 on on IN cord-010092-uftc8inx 3767 11 AM AM NNP cord-010092-uftc8inx 3767 12 shift shift NN cord-010092-uftc8inx 3767 13 and and CC cord-010092-uftc8inx 3767 14 4 4 CD cord-010092-uftc8inx 3767 15 staff staff NN cord-010092-uftc8inx 3767 16 on on IN cord-010092-uftc8inx 3767 17 PM PM NNP cord-010092-uftc8inx 3767 18 shift shift NN cord-010092-uftc8inx 3767 19 was be VBD cord-010092-uftc8inx 3767 20 conducted conduct VBN cord-010092-uftc8inx 3767 21 . . . cord-010092-uftc8inx 3768 1 The the DT cord-010092-uftc8inx 3768 2 total total JJ cord-010092-uftc8inx 3768 3 number number NN cord-010092-uftc8inx 3768 4 of of IN cord-010092-uftc8inx 3768 5 PM pm NN cord-010092-uftc8inx 3768 6 shift shift NN cord-010092-uftc8inx 3768 7 per per IN cord-010092-uftc8inx 3768 8 month month NN cord-010092-uftc8inx 3768 9 was be VBD cord-010092-uftc8inx 3768 10 reduced reduce VBN cord-010092-uftc8inx 3768 11 from from IN cord-010092-uftc8inx 3768 12 124 124 CD cord-010092-uftc8inx 3768 13 to to TO cord-010092-uftc8inx 3768 14 112 112 CD cord-010092-uftc8inx 3768 15 using use VBG cord-010092-uftc8inx 3768 16 the the DT cord-010092-uftc8inx 3768 17 re re NN cord-010092-uftc8inx 3768 18 - - JJ cord-010092-uftc8inx 3768 19 defined define VBN cord-010092-uftc8inx 3768 20 process process NN cord-010092-uftc8inx 3768 21 . . . cord-010092-uftc8inx 3769 1 The the DT cord-010092-uftc8inx 3769 2 10 10 CD cord-010092-uftc8inx 3769 3 % % NN cord-010092-uftc8inx 3769 4 reduction reduction NN cord-010092-uftc8inx 3769 5 translates translate VBZ cord-010092-uftc8inx 3769 6 to to IN cord-010092-uftc8inx 3769 7 fewer few JJR cord-010092-uftc8inx 3769 8 number number NN cord-010092-uftc8inx 3769 9 of of IN cord-010092-uftc8inx 3769 10 PM pm NN cord-010092-uftc8inx 3769 11 shifts shift NNS cord-010092-uftc8inx 3769 12 that that IN cord-010092-uftc8inx 3769 13 the the DT cord-010092-uftc8inx 3769 14 staff staff NN cord-010092-uftc8inx 3769 15 has have VBZ cord-010092-uftc8inx 3769 16 to to TO cord-010092-uftc8inx 3769 17 undertake undertake VB cord-010092-uftc8inx 3769 18 and and CC cord-010092-uftc8inx 3769 19 was be VBD cord-010092-uftc8inx 3769 20 able able JJ cord-010092-uftc8inx 3769 21 to to TO cord-010092-uftc8inx 3769 22 meet meet VB cord-010092-uftc8inx 3769 23 the the DT cord-010092-uftc8inx 3769 24 staff staff NN cord-010092-uftc8inx 3769 25 's 's POS cord-010092-uftc8inx 3769 26 expectation expectation NN cord-010092-uftc8inx 3769 27 . . . cord-010092-uftc8inx 3770 1 Summary Summary NNP cord-010092-uftc8inx 3770 2 / / SYM cord-010092-uftc8inx 3770 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 3770 4 : : : cord-010092-uftc8inx 3771 1 With with IN cord-010092-uftc8inx 3771 2 the the DT cord-010092-uftc8inx 3771 3 adoption adoption NN cord-010092-uftc8inx 3771 4 of of IN cord-010092-uftc8inx 3771 5 the the DT cord-010092-uftc8inx 3771 6 new new JJ cord-010092-uftc8inx 3771 7 process process NN cord-010092-uftc8inx 3771 8 workflow workflow NN cord-010092-uftc8inx 3771 9 , , , cord-010092-uftc8inx 3771 10 BDT BDT NNP cord-010092-uftc8inx 3771 11 Lab Lab NNP cord-010092-uftc8inx 3771 12 was be VBD cord-010092-uftc8inx 3771 13 able able JJ cord-010092-uftc8inx 3771 14 to to TO cord-010092-uftc8inx 3771 15 reduce reduce VB cord-010092-uftc8inx 3771 16 the the DT cord-010092-uftc8inx 3771 17 number number NN cord-010092-uftc8inx 3771 18 of of IN cord-010092-uftc8inx 3771 19 PM pm NN cord-010092-uftc8inx 3771 20 shifts shift NNS cord-010092-uftc8inx 3771 21 that that IN cord-010092-uftc8inx 3771 22 the the DT cord-010092-uftc8inx 3771 23 staff staff NN cord-010092-uftc8inx 3771 24 needs need VBZ cord-010092-uftc8inx 3771 25 to to TO cord-010092-uftc8inx 3771 26 be be VB cord-010092-uftc8inx 3771 27 rostered rostere VBN cord-010092-uftc8inx 3771 28 using use VBG cord-010092-uftc8inx 3771 29 evidence evidence NN cord-010092-uftc8inx 3771 30 based base VBN cord-010092-uftc8inx 3771 31 process process NN cord-010092-uftc8inx 3771 32 improvement improvement NN cord-010092-uftc8inx 3771 33 method method NN cord-010092-uftc8inx 3771 34 . . . cord-010092-uftc8inx 3772 1 Most most RBS cord-010092-uftc8inx 3772 2 importantly importantly RB cord-010092-uftc8inx 3772 3 , , , cord-010092-uftc8inx 3772 4 the the DT cord-010092-uftc8inx 3772 5 lab lab NN cord-010092-uftc8inx 3772 6 has have VBZ cord-010092-uftc8inx 3772 7 a a DT cord-010092-uftc8inx 3772 8 satisfied satisfied JJ cord-010092-uftc8inx 3772 9 team team NN cord-010092-uftc8inx 3772 10 of of IN cord-010092-uftc8inx 3772 11 staff staff NN cord-010092-uftc8inx 3772 12 with with IN cord-010092-uftc8inx 3772 13 better well JJR cord-010092-uftc8inx 3772 14 work work NN cord-010092-uftc8inx 3772 15 - - HYPH cord-010092-uftc8inx 3772 16 life life NN cord-010092-uftc8inx 3772 17 balance balance NN cord-010092-uftc8inx 3772 18 . . . cord-010092-uftc8inx 3773 1 Background background NN cord-010092-uftc8inx 3773 2 : : : cord-010092-uftc8inx 3774 1 Preparedness preparedness NN cord-010092-uftc8inx 3774 2 of of IN cord-010092-uftc8inx 3774 3 blood blood NN cord-010092-uftc8inx 3774 4 transfusion transfusion NN cord-010092-uftc8inx 3774 5 services service NNS cord-010092-uftc8inx 3774 6 for for IN cord-010092-uftc8inx 3774 7 emergencies emergency NNS cord-010092-uftc8inx 3774 8 and and CC cord-010092-uftc8inx 3774 9 crisis crisis NN cord-010092-uftc8inx 3774 10 situations situation NNS cord-010092-uftc8inx 3774 11 is be VBZ cord-010092-uftc8inx 3774 12 an an DT cord-010092-uftc8inx 3774 13 important important JJ cord-010092-uftc8inx 3774 14 issue issue NN cord-010092-uftc8inx 3774 15 concerned concern VBN cord-010092-uftc8inx 3774 16 with with IN cord-010092-uftc8inx 3774 17 patient patient NN cord-010092-uftc8inx 3774 18 and and CC cord-010092-uftc8inx 3774 19 transfusion transfusion NN cord-010092-uftc8inx 3774 20 safety safety NN cord-010092-uftc8inx 3774 21 . . . cord-010092-uftc8inx 3775 1 Aims aim VBZ cord-010092-uftc8inx 3775 2 : : : cord-010092-uftc8inx 3776 1 Having have VBG cord-010092-uftc8inx 3776 2 an an DT cord-010092-uftc8inx 3776 3 experience experience NN cord-010092-uftc8inx 3776 4 of of IN cord-010092-uftc8inx 3776 5 delay delay NN cord-010092-uftc8inx 3776 6 in in IN cord-010092-uftc8inx 3776 7 blood blood NN cord-010092-uftc8inx 3776 8 component component NN cord-010092-uftc8inx 3776 9 supply supply NN cord-010092-uftc8inx 3776 10 in in IN cord-010092-uftc8inx 3776 11 an an DT cord-010092-uftc8inx 3776 12 emergency emergency NN cord-010092-uftc8inx 3776 13 situation situation NN cord-010092-uftc8inx 3776 14 due due JJ cord-010092-uftc8inx 3776 15 to to IN cord-010092-uftc8inx 3776 16 partial partial JJ cord-010092-uftc8inx 3776 17 interruption interruption NN cord-010092-uftc8inx 3776 18 of of IN cord-010092-uftc8inx 3776 19 Hospital Hospital NNP cord-010092-uftc8inx 3776 20 Information Information NNP cord-010092-uftc8inx 3776 21 System System NNP cord-010092-uftc8inx 3776 22 ( ( -LRB- cord-010092-uftc8inx 3776 23 HIS his PRP$ cord-010092-uftc8inx 3776 24 ) ) -RRB- cord-010092-uftc8inx 3776 25 , , , cord-010092-uftc8inx 3776 26 it -PRON- PRP cord-010092-uftc8inx 3776 27 is be VBZ cord-010092-uftc8inx 3776 28 aimed aim VBN cord-010092-uftc8inx 3776 29 to to TO cord-010092-uftc8inx 3776 30 create create VB cord-010092-uftc8inx 3776 31 a a DT cord-010092-uftc8inx 3776 32 crisis crisis NN cord-010092-uftc8inx 3776 33 kit kit NN cord-010092-uftc8inx 3776 34 and and CC cord-010092-uftc8inx 3776 35 constitute constitute VB cord-010092-uftc8inx 3776 36 an an DT cord-010092-uftc8inx 3776 37 alternative alternative JJ cord-010092-uftc8inx 3776 38 work work NN cord-010092-uftc8inx 3776 39 flow flow NN cord-010092-uftc8inx 3776 40 for for IN cord-010092-uftc8inx 3776 41 emergency emergency NN cord-010092-uftc8inx 3776 42 in in IN cord-010092-uftc8inx 3776 43 crisis crisis NN cord-010092-uftc8inx 3776 44 situations situation NNS cord-010092-uftc8inx 3776 45 . . . cord-010092-uftc8inx 3777 1 Methods method NNS cord-010092-uftc8inx 3777 2 : : : cord-010092-uftc8inx 3777 3 It -PRON- PRP cord-010092-uftc8inx 3777 4 is be VBZ cord-010092-uftc8inx 3777 5 stipulated stipulate VBN cord-010092-uftc8inx 3777 6 that that IN cord-010092-uftc8inx 3777 7 the the DT cord-010092-uftc8inx 3777 8 failure failure NN cord-010092-uftc8inx 3777 9 of of IN cord-010092-uftc8inx 3777 10 HIS his PRP$ cord-010092-uftc8inx 3777 11 which which WDT cord-010092-uftc8inx 3777 12 is be VBZ cord-010092-uftc8inx 3777 13 normally normally RB cord-010092-uftc8inx 3777 14 conducts conduct VBZ cord-010092-uftc8inx 3777 15 all all DT cord-010092-uftc8inx 3777 16 process process NN cord-010092-uftc8inx 3777 17 for for IN cord-010092-uftc8inx 3777 18 transfusion transfusion NN cord-010092-uftc8inx 3777 19 would would MD cord-010092-uftc8inx 3777 20 be be VB cord-010092-uftc8inx 3777 21 disabled disable VBN cord-010092-uftc8inx 3777 22 in in IN cord-010092-uftc8inx 3777 23 a a DT cord-010092-uftc8inx 3777 24 disaster disaster NN cord-010092-uftc8inx 3777 25 or or CC cord-010092-uftc8inx 3777 26 crisis crisis NN cord-010092-uftc8inx 3777 27 situation situation NN cord-010092-uftc8inx 3777 28 . . . cord-010092-uftc8inx 3778 1 A a DT cord-010092-uftc8inx 3778 2 brain brain NN cord-010092-uftc8inx 3778 3 storm storm NN cord-010092-uftc8inx 3778 4 was be VBD cord-010092-uftc8inx 3778 5 made make VBN cord-010092-uftc8inx 3778 6 on on IN cord-010092-uftc8inx 3778 7 possible possible JJ cord-010092-uftc8inx 3778 8 challenges challenge NNS cord-010092-uftc8inx 3778 9 associated associate VBN cord-010092-uftc8inx 3778 10 with with IN cord-010092-uftc8inx 3778 11 disability disability NN cord-010092-uftc8inx 3778 12 of of IN cord-010092-uftc8inx 3778 13 HIS his PRP cord-010092-uftc8inx 3778 14 during during IN cord-010092-uftc8inx 3778 15 transfusion transfusion NN cord-010092-uftc8inx 3778 16 emergencies emergency NNS cord-010092-uftc8inx 3778 17 . . . cord-010092-uftc8inx 3779 1 According accord VBG cord-010092-uftc8inx 3779 2 to to IN cord-010092-uftc8inx 3779 3 the the DT cord-010092-uftc8inx 3779 4 scenarios scenario NNS cord-010092-uftc8inx 3779 5 a a DT cord-010092-uftc8inx 3779 6 kit kit NN cord-010092-uftc8inx 3779 7 was be VBD cord-010092-uftc8inx 3779 8 developed develop VBN cord-010092-uftc8inx 3779 9 for for IN cord-010092-uftc8inx 3779 10 the the DT cord-010092-uftc8inx 3779 11 process process NN cord-010092-uftc8inx 3779 12 management management NN cord-010092-uftc8inx 3779 13 of of IN cord-010092-uftc8inx 3779 14 transfusion transfusion NN cord-010092-uftc8inx 3779 15 emergencies emergency NNS cord-010092-uftc8inx 3779 16 . . . cord-010092-uftc8inx 3780 1 Results result NNS cord-010092-uftc8inx 3780 2 : : : cord-010092-uftc8inx 3781 1 A a DT cord-010092-uftc8inx 3781 2 flow flow NN cord-010092-uftc8inx 3781 3 chart chart NN cord-010092-uftc8inx 3781 4 was be VBD cord-010092-uftc8inx 3781 5 designed design VBN cord-010092-uftc8inx 3781 6 in in IN cord-010092-uftc8inx 3781 7 proper proper JJ cord-010092-uftc8inx 3781 8 with with IN cord-010092-uftc8inx 3781 9 transfusion transfusion NN cord-010092-uftc8inx 3781 10 emergency emergency NN cord-010092-uftc8inx 3781 11 definitions definition NNS cord-010092-uftc8inx 3781 12 of of IN cord-010092-uftc8inx 3781 13 WHO who WP cord-010092-uftc8inx 3781 14 and and CC cord-010092-uftc8inx 3781 15 instructions instruction NNS cord-010092-uftc8inx 3781 16 were be VBD cord-010092-uftc8inx 3781 17 written write VBN cord-010092-uftc8inx 3781 18 to to TO cord-010092-uftc8inx 3781 19 explain explain VB cord-010092-uftc8inx 3781 20 the the DT cord-010092-uftc8inx 3781 21 flow flow NN cord-010092-uftc8inx 3781 22 chart chart NN cord-010092-uftc8inx 3781 23 . . . cord-010092-uftc8inx 3782 1 All all DT cord-010092-uftc8inx 3782 2 forms form NNS cord-010092-uftc8inx 3782 3 categorized categorize VBN cord-010092-uftc8inx 3782 4 with with IN cord-010092-uftc8inx 3782 5 different different JJ cord-010092-uftc8inx 3782 6 colour colour NN cord-010092-uftc8inx 3782 7 codes code NNS cord-010092-uftc8inx 3782 8 are be VBP cord-010092-uftc8inx 3782 9 designed design VBN cord-010092-uftc8inx 3782 10 to to TO cord-010092-uftc8inx 3782 11 fill fill VB cord-010092-uftc8inx 3782 12 with with IN cord-010092-uftc8inx 3782 13 handwriting handwriting NN cord-010092-uftc8inx 3782 14 . . . cord-010092-uftc8inx 3783 1 The the DT cord-010092-uftc8inx 3783 2 kit kit NN cord-010092-uftc8inx 3783 3 consists consist VBZ cord-010092-uftc8inx 3783 4 of of IN cord-010092-uftc8inx 3783 5 flow flow NN cord-010092-uftc8inx 3783 6 chart chart NN cord-010092-uftc8inx 3783 7 and and CC cord-010092-uftc8inx 3783 8 instructions instruction NNS cord-010092-uftc8inx 3783 9 , , , cord-010092-uftc8inx 3783 10 Analysis Analysis NNP cord-010092-uftc8inx 3783 11 Request request NN cord-010092-uftc8inx 3783 12 Forms Forms NNP cord-010092-uftc8inx 3783 13 ( ( -LRB- cord-010092-uftc8inx 3783 14 blue blue JJ cord-010092-uftc8inx 3783 15 coloured coloured JJ cord-010092-uftc8inx 3783 16 ) ) -RRB- cord-010092-uftc8inx 3783 17 , , , cord-010092-uftc8inx 3783 18 Blood blood NN cord-010092-uftc8inx 3783 19 Component Component NNP cord-010092-uftc8inx 3783 20 Request request NN cord-010092-uftc8inx 3783 21 Forms Forms NNP cord-010092-uftc8inx 3783 22 ( ( -LRB- cord-010092-uftc8inx 3783 23 pink pink JJ cord-010092-uftc8inx 3783 24 coloured coloured JJ cord-010092-uftc8inx 3783 25 ) ) -RRB- cord-010092-uftc8inx 3783 26 , , , cord-010092-uftc8inx 3783 27 Proceeding Proceeding NNP cord-010092-uftc8inx 3783 28 Forms Forms NNP cord-010092-uftc8inx 3783 29 ( ( -LRB- cord-010092-uftc8inx 3783 30 green green JJ cord-010092-uftc8inx 3783 31 coloured coloured JJ cord-010092-uftc8inx 3783 32 ) ) -RRB- cord-010092-uftc8inx 3783 33 , , , cord-010092-uftc8inx 3783 34 pens pen NNS cord-010092-uftc8inx 3783 35 and and CC cord-010092-uftc8inx 3783 36 blood blood NN cord-010092-uftc8inx 3783 37 sample sample NN cord-010092-uftc8inx 3783 38 tubes tube NNS cord-010092-uftc8inx 3783 39 with with IN cord-010092-uftc8inx 3783 40 EDTA EDTA NNP cord-010092-uftc8inx 3783 41 were be VBD cord-010092-uftc8inx 3783 42 put put VBN cord-010092-uftc8inx 3783 43 into into IN cord-010092-uftc8inx 3783 44 a a DT cord-010092-uftc8inx 3783 45 plastic plastic NN cord-010092-uftc8inx 3783 46 folder folder NN cord-010092-uftc8inx 3783 47 labelled label VBN cord-010092-uftc8inx 3783 48 as as IN cord-010092-uftc8inx 3783 49 Transfusion Transfusion NNP cord-010092-uftc8inx 3783 50 Emergency Emergency NNP cord-010092-uftc8inx 3783 51 Disaster Disaster NNP cord-010092-uftc8inx 3783 52 & & CC cord-010092-uftc8inx 3783 53 Crisis Crisis NNP cord-010092-uftc8inx 3783 54 ( ( -LRB- cord-010092-uftc8inx 3783 55 TEDC TEDC NNP cord-010092-uftc8inx 3783 56 ) ) -RRB- cord-010092-uftc8inx 3783 57 Kit kit NN cord-010092-uftc8inx 3783 58 . . . cord-010092-uftc8inx 3784 1 Additionally additionally RB cord-010092-uftc8inx 3784 2 , , , cord-010092-uftc8inx 3784 3 the the DT cord-010092-uftc8inx 3784 4 kit kit NN cord-010092-uftc8inx 3784 5 is be VBZ cord-010092-uftc8inx 3784 6 placed place VBN cord-010092-uftc8inx 3784 7 in in IN cord-010092-uftc8inx 3784 8 a a DT cord-010092-uftc8inx 3784 9 sealed sealed JJ cord-010092-uftc8inx 3784 10 clear clear JJ cord-010092-uftc8inx 3784 11 plastic plastic NN cord-010092-uftc8inx 3784 12 bag bag NN cord-010092-uftc8inx 3784 13 and and CC cord-010092-uftc8inx 3784 14 delivered deliver VBD cord-010092-uftc8inx 3784 15 to to IN cord-010092-uftc8inx 3784 16 all all DT cord-010092-uftc8inx 3784 17 inpatient inpatient JJ cord-010092-uftc8inx 3784 18 and and CC cord-010092-uftc8inx 3784 19 intensive intensive JJ cord-010092-uftc8inx 3784 20 care care NN cord-010092-uftc8inx 3784 21 units unit NNS cord-010092-uftc8inx 3784 22 of of IN cord-010092-uftc8inx 3784 23 pediatrics pediatric NNS cord-010092-uftc8inx 3784 24 and and CC cord-010092-uftc8inx 3784 25 pediatric pediatric JJ cord-010092-uftc8inx 3784 26 surgery surgery NN cord-010092-uftc8inx 3784 27 . . . cord-010092-uftc8inx 3785 1 A a DT cord-010092-uftc8inx 3785 2 training training NN cord-010092-uftc8inx 3785 3 programme programme NN cord-010092-uftc8inx 3785 4 concerned concern VBN cord-010092-uftc8inx 3785 5 with with IN cord-010092-uftc8inx 3785 6 transfusion transfusion NN cord-010092-uftc8inx 3785 7 emergency emergency NN cord-010092-uftc8inx 3785 8 situations situation NNS cord-010092-uftc8inx 3785 9 and and CC cord-010092-uftc8inx 3785 10 usage usage NN cord-010092-uftc8inx 3785 11 of of IN cord-010092-uftc8inx 3785 12 the the DT cord-010092-uftc8inx 3785 13 TEDC TEDC NNP cord-010092-uftc8inx 3785 14 kit kit NN cord-010092-uftc8inx 3785 15 was be VBD cord-010092-uftc8inx 3785 16 developed develop VBN cord-010092-uftc8inx 3785 17 for for IN cord-010092-uftc8inx 3785 18 health health NN cord-010092-uftc8inx 3785 19 care care NN cord-010092-uftc8inx 3785 20 workers worker NNS cord-010092-uftc8inx 3785 21 involved involve VBN cord-010092-uftc8inx 3785 22 in in IN cord-010092-uftc8inx 3785 23 blood blood NN cord-010092-uftc8inx 3785 24 transfusion transfusion NN cord-010092-uftc8inx 3785 25 process process NN cord-010092-uftc8inx 3785 26 . . . cord-010092-uftc8inx 3786 1 Pre pre JJ cord-010092-uftc8inx 3786 2 and and CC cord-010092-uftc8inx 3786 3 post post JJ cord-010092-uftc8inx 3786 4 - - JJ cord-010092-uftc8inx 3786 5 assessment assessment JJ cord-010092-uftc8inx 3786 6 tests test NNS cord-010092-uftc8inx 3786 7 were be VBD cord-010092-uftc8inx 3786 8 developed develop VBN cord-010092-uftc8inx 3786 9 for for IN cord-010092-uftc8inx 3786 10 the the DT cord-010092-uftc8inx 3786 11 evaluation evaluation NN cord-010092-uftc8inx 3786 12 of of IN cord-010092-uftc8inx 3786 13 effectiveness effectiveness NN cord-010092-uftc8inx 3786 14 of of IN cord-010092-uftc8inx 3786 15 the the DT cord-010092-uftc8inx 3786 16 training training NN cord-010092-uftc8inx 3786 17 programme programme NN cord-010092-uftc8inx 3786 18 . . . cord-010092-uftc8inx 3787 1 Summary Summary NNP cord-010092-uftc8inx 3787 2 / / SYM cord-010092-uftc8inx 3787 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 3787 4 : : : cord-010092-uftc8inx 3788 1 It -PRON- PRP cord-010092-uftc8inx 3788 2 's be VBZ cord-010092-uftc8inx 3788 3 challenging challenging JJ cord-010092-uftc8inx 3788 4 to to TO cord-010092-uftc8inx 3788 5 improve improve VB cord-010092-uftc8inx 3788 6 the the DT cord-010092-uftc8inx 3788 7 response response NN cord-010092-uftc8inx 3788 8 capacity capacity NN cord-010092-uftc8inx 3788 9 of of IN cord-010092-uftc8inx 3788 10 blood blood NN cord-010092-uftc8inx 3788 11 transfusion transfusion NN cord-010092-uftc8inx 3788 12 services service NNS cord-010092-uftc8inx 3788 13 during during IN cord-010092-uftc8inx 3788 14 emergencies emergency NNS cord-010092-uftc8inx 3788 15 and and CC cord-010092-uftc8inx 3788 16 crisis crisis NN cord-010092-uftc8inx 3788 17 situations situation NNS cord-010092-uftc8inx 3788 18 . . . cord-010092-uftc8inx 3789 1 Abstract Abstract NNP cord-010092-uftc8inx 3789 2 withdrawn withdraw VBN cord-010092-uftc8inx 3789 3 . . . cord-010092-uftc8inx 3790 1 Background background NN cord-010092-uftc8inx 3790 2 : : : cord-010092-uftc8inx 3791 1 India India NNP cord-010092-uftc8inx 3791 2 is be VBZ cord-010092-uftc8inx 3791 3 a a DT cord-010092-uftc8inx 3791 4 developing develop VBG cord-010092-uftc8inx 3791 5 country country NN cord-010092-uftc8inx 3791 6 having have VBG cord-010092-uftc8inx 3791 7 2760 2760 CD cord-010092-uftc8inx 3791 8 licensed licensed JJ cord-010092-uftc8inx 3791 9 blood blood NN cord-010092-uftc8inx 3791 10 banks bank NNS cord-010092-uftc8inx 3791 11 Majority Majority NNP cord-010092-uftc8inx 3791 12 have have VBP cord-010092-uftc8inx 3791 13 manual manual JJ cord-010092-uftc8inx 3791 14 documentation documentation NN cord-010092-uftc8inx 3791 15 which which WDT cord-010092-uftc8inx 3791 16 causes cause VBZ cord-010092-uftc8inx 3791 17 inaccuracies inaccuracy NNS cord-010092-uftc8inx 3791 18 and and CC cord-010092-uftc8inx 3791 19 errors error NNS cord-010092-uftc8inx 3791 20 in in IN cord-010092-uftc8inx 3791 21 blood blood NN cord-010092-uftc8inx 3791 22 bank bank NN cord-010092-uftc8inx 3791 23 activities activity NNS cord-010092-uftc8inx 3791 24 . . . cord-010092-uftc8inx 3792 1 Monitoring monitoring NN cord-010092-uftc8inx 3792 2 is be VBZ cord-010092-uftc8inx 3792 3 a a DT cord-010092-uftc8inx 3792 4 herculean herculean JJ cord-010092-uftc8inx 3792 5 task task NN cord-010092-uftc8inx 3792 6 . . . cord-010092-uftc8inx 3793 1 Computerisation Computerisation NNP cord-010092-uftc8inx 3793 2 is be VBZ cord-010092-uftc8inx 3793 3 the the DT cord-010092-uftc8inx 3793 4 need need NN cord-010092-uftc8inx 3793 5 of of IN cord-010092-uftc8inx 3793 6 the the DT cord-010092-uftc8inx 3793 7 hour hour NN cord-010092-uftc8inx 3794 1 but but CC cord-010092-uftc8inx 3794 2 this this DT cord-010092-uftc8inx 3794 3 goal goal NN cord-010092-uftc8inx 3794 4 involves involve VBZ cord-010092-uftc8inx 3794 5 many many JJ cord-010092-uftc8inx 3794 6 hurdles hurdle NNS cord-010092-uftc8inx 3794 7 and and CC cord-010092-uftc8inx 3794 8 challenges challenge NNS cord-010092-uftc8inx 3795 1 Aims aim NNS cord-010092-uftc8inx 3796 1 : : : cord-010092-uftc8inx 3796 2 The the DT cord-010092-uftc8inx 3796 3 aim aim NN cord-010092-uftc8inx 3796 4 of of IN cord-010092-uftc8inx 3796 5 this this DT cord-010092-uftc8inx 3796 6 study study NN cord-010092-uftc8inx 3796 7 is be VBZ cord-010092-uftc8inx 3796 8 to to TO cord-010092-uftc8inx 3796 9 discuss discuss VB cord-010092-uftc8inx 3796 10 the the DT cord-010092-uftc8inx 3796 11 challenges challenge NNS cord-010092-uftc8inx 3796 12 faced face VBN cord-010092-uftc8inx 3796 13 during during IN cord-010092-uftc8inx 3796 14 computerisation computerisation NN cord-010092-uftc8inx 3796 15 of of IN cord-010092-uftc8inx 3796 16 blood blood NN cord-010092-uftc8inx 3796 17 bank bank NN cord-010092-uftc8inx 3796 18 activities activity NNS cord-010092-uftc8inx 3796 19 and and CC cord-010092-uftc8inx 3796 20 the the DT cord-010092-uftc8inx 3796 21 remedial remedial JJ cord-010092-uftc8inx 3796 22 solutions solution NNS cord-010092-uftc8inx 3796 23 for for IN cord-010092-uftc8inx 3796 24 it -PRON- PRP cord-010092-uftc8inx 3796 25 Methods method NNS cord-010092-uftc8inx 3796 26 : : : cord-010092-uftc8inx 3796 27 Department Department NNP cord-010092-uftc8inx 3796 28 of of IN cord-010092-uftc8inx 3796 29 Transfusion Transfusion NNP cord-010092-uftc8inx 3796 30 Medicine Medicine NNP cord-010092-uftc8inx 3796 31 , , , cord-010092-uftc8inx 3796 32 King King NNP cord-010092-uftc8inx 3796 33 George George NNP cord-010092-uftc8inx 3796 34 medical medical NNP cord-010092-uftc8inx 3796 35 University University NNP cord-010092-uftc8inx 3796 36 , , , cord-010092-uftc8inx 3796 37 Lucknow Lucknow NNP cord-010092-uftc8inx 3796 38 is be VBZ cord-010092-uftc8inx 3796 39 one one CD cord-010092-uftc8inx 3796 40 of of IN cord-010092-uftc8inx 3796 41 the the DT cord-010092-uftc8inx 3796 42 biggest big JJS cord-010092-uftc8inx 3796 43 blood blood NN cord-010092-uftc8inx 3796 44 bank bank NN cord-010092-uftc8inx 3796 45 of of IN cord-010092-uftc8inx 3796 46 the the DT cord-010092-uftc8inx 3796 47 country country NN cord-010092-uftc8inx 3796 48 with with IN cord-010092-uftc8inx 3796 49 annual annual JJ cord-010092-uftc8inx 3796 50 collection collection NN cord-010092-uftc8inx 3796 51 of of IN cord-010092-uftc8inx 3796 52 70,000 70,000 CD cord-010092-uftc8inx 3796 53 blood blood NN cord-010092-uftc8inx 3796 54 units unit NNS cord-010092-uftc8inx 3796 55 . . . cord-010092-uftc8inx 3797 1 Two two CD cord-010092-uftc8inx 3797 2 years year NNS cord-010092-uftc8inx 3797 3 ago ago RB cord-010092-uftc8inx 3797 4 , , , cord-010092-uftc8inx 3797 5 the the DT cord-010092-uftc8inx 3797 6 blood blood NN cord-010092-uftc8inx 3797 7 bank bank NN cord-010092-uftc8inx 3797 8 worked work VBD cord-010092-uftc8inx 3797 9 on on IN cord-010092-uftc8inx 3797 10 totally totally RB cord-010092-uftc8inx 3797 11 manual manual JJ cord-010092-uftc8inx 3797 12 system system NN cord-010092-uftc8inx 3797 13 . . . cord-010092-uftc8inx 3798 1 Computerisation computerisation NN cord-010092-uftc8inx 3798 2 involved involve VBD cord-010092-uftc8inx 3798 3 challenges challenge NNS cord-010092-uftc8inx 3798 4 associated associate VBN cord-010092-uftc8inx 3798 5 with with IN cord-010092-uftc8inx 3798 6 hardware hardware NN cord-010092-uftc8inx 3798 7 and and CC cord-010092-uftc8inx 3798 8 software software NN cord-010092-uftc8inx 3798 9 installation installation NN cord-010092-uftc8inx 3798 10 and and CC cord-010092-uftc8inx 3798 11 personnel personnel NNS cord-010092-uftc8inx 3798 12 training training NN cord-010092-uftc8inx 3798 13 . . . cord-010092-uftc8inx 3799 1 Hardware hardware NN cord-010092-uftc8inx 3799 2 was be VBD cord-010092-uftc8inx 3799 3 installed instal VBN cord-010092-uftc8inx 3799 4 in in IN cord-010092-uftc8inx 3799 5 two two CD cord-010092-uftc8inx 3799 6 phases phase NNS cord-010092-uftc8inx 3799 7 . . . cord-010092-uftc8inx 3800 1 Initially initially RB cord-010092-uftc8inx 3800 2 HP HP NNP cord-010092-uftc8inx 3800 3 system system NN cord-010092-uftc8inx 3800 4 but but CC cord-010092-uftc8inx 3800 5 later later RB cord-010092-uftc8inx 3800 6 shifted shift VBD cord-010092-uftc8inx 3800 7 to to IN cord-010092-uftc8inx 3800 8 Apple Apple NNP cord-010092-uftc8inx 3800 9 iMac iMac NNP cord-010092-uftc8inx 3800 10 due due IN cord-010092-uftc8inx 3800 11 to to IN cord-010092-uftc8inx 3800 12 frequent frequent JJ cord-010092-uftc8inx 3800 13 breakdowns breakdown NNS cord-010092-uftc8inx 3800 14 . . . cord-010092-uftc8inx 3801 1 With with IN cord-010092-uftc8inx 3801 2 HP HP NNP cord-010092-uftc8inx 3801 3 server server NN cord-010092-uftc8inx 3801 4 . . . cord-010092-uftc8inx 3802 1 Software software NN cord-010092-uftc8inx 3802 2 installation installation NN cord-010092-uftc8inx 3802 3 ( ( -LRB- cord-010092-uftc8inx 3802 4 Easy easy JJ cord-010092-uftc8inx 3802 5 software software NN cord-010092-uftc8inx 3802 6 ) ) -RRB- cord-010092-uftc8inx 3802 7 involved involve VBN cord-010092-uftc8inx 3802 8 erratic erratic JJ cord-010092-uftc8inx 3802 9 internet internet NN cord-010092-uftc8inx 3802 10 connectivity connectivity NN cord-010092-uftc8inx 3802 11 hence hence RB cord-010092-uftc8inx 3802 12 changed change VBD cord-010092-uftc8inx 3802 13 to to IN cord-010092-uftc8inx 3802 14 LAN LAN NNP cord-010092-uftc8inx 3802 15 . . . cord-010092-uftc8inx 3803 1 Customisation customisation NN cord-010092-uftc8inx 3803 2 involved involve VBD cord-010092-uftc8inx 3803 3 radical radical JJ cord-010092-uftc8inx 3803 4 changes change NNS cord-010092-uftc8inx 3803 5 according accord VBG cord-010092-uftc8inx 3803 6 to to IN cord-010092-uftc8inx 3803 7 our -PRON- PRP$ cord-010092-uftc8inx 3803 8 needs need NNS cord-010092-uftc8inx 3803 9 . . . cord-010092-uftc8inx 3804 1 At at IN cord-010092-uftc8inx 3804 2 times time NNS cord-010092-uftc8inx 3804 3 we -PRON- PRP cord-010092-uftc8inx 3804 4 had have VBD cord-010092-uftc8inx 3804 5 to to TO cord-010092-uftc8inx 3804 6 change change VB cord-010092-uftc8inx 3804 7 our -PRON- PRP$ cord-010092-uftc8inx 3804 8 way way NN cord-010092-uftc8inx 3804 9 of of IN cord-010092-uftc8inx 3804 10 working work VBG cord-010092-uftc8inx 3804 11 to to TO cord-010092-uftc8inx 3804 12 suit suit VB cord-010092-uftc8inx 3804 13 the the DT cord-010092-uftc8inx 3804 14 software software NN cord-010092-uftc8inx 3804 15 . . . cord-010092-uftc8inx 3805 1 Biometrics biometric NNS cord-010092-uftc8inx 3805 2 linking link VBG cord-010092-uftc8inx 3805 3 , , , cord-010092-uftc8inx 3805 4 medical medical JJ cord-010092-uftc8inx 3805 5 registration registration NN cord-010092-uftc8inx 3805 6 , , , cord-010092-uftc8inx 3805 7 cash cash NN cord-010092-uftc8inx 3805 8 i -PRON- PRP cord-010092-uftc8inx 3805 9 d d NN cord-010092-uftc8inx 3805 10 generation generation NN cord-010092-uftc8inx 3805 11 , , , cord-010092-uftc8inx 3805 12 donation donation NN cord-010092-uftc8inx 3805 13 , , , cord-010092-uftc8inx 3805 14 serological serological JJ cord-010092-uftc8inx 3805 15 crossmatch crossmatch NN cord-010092-uftc8inx 3805 16 , , , cord-010092-uftc8inx 3805 17 automated automate VBN cord-010092-uftc8inx 3805 18 blood blood NN cord-010092-uftc8inx 3805 19 grouping grouping NN cord-010092-uftc8inx 3805 20 , , , cord-010092-uftc8inx 3805 21 labelling labelling NN cord-010092-uftc8inx 3805 22 , , , cord-010092-uftc8inx 3805 23 chemiluminescence chemiluminescence NNP cord-010092-uftc8inx 3805 24 & & CC cord-010092-uftc8inx 3805 25 NAT NAT NNP cord-010092-uftc8inx 3805 26 testing testing NN cord-010092-uftc8inx 3805 27 , , , cord-010092-uftc8inx 3805 28 blood blood NN cord-010092-uftc8inx 3805 29 component component NN cord-010092-uftc8inx 3805 30 preparation preparation NN cord-010092-uftc8inx 3805 31 and and CC cord-010092-uftc8inx 3805 32 camps camp NNS cord-010092-uftc8inx 3805 33 were be VBD cord-010092-uftc8inx 3805 34 all all DT cord-010092-uftc8inx 3805 35 included include VBN cord-010092-uftc8inx 3805 36 with with IN cord-010092-uftc8inx 3805 37 challenges challenge NNS cord-010092-uftc8inx 3805 38 at at IN cord-010092-uftc8inx 3805 39 every every DT cord-010092-uftc8inx 3805 40 level level NN cord-010092-uftc8inx 3805 41 . . . cord-010092-uftc8inx 3806 1 Remedial remedial JJ cord-010092-uftc8inx 3806 2 actions action NNS cord-010092-uftc8inx 3806 3 were be VBD cord-010092-uftc8inx 3806 4 taken take VBN cord-010092-uftc8inx 3806 5 from from IN cord-010092-uftc8inx 3806 6 small small JJ cord-010092-uftc8inx 3806 7 to to TO cord-010092-uftc8inx 3806 8 big big JJ cord-010092-uftc8inx 3806 9 . . . cord-010092-uftc8inx 3807 1 Training training NN cord-010092-uftc8inx 3807 2 of of IN cord-010092-uftc8inx 3807 3 the the DT cord-010092-uftc8inx 3807 4 staff staff NN cord-010092-uftc8inx 3807 5 was be VBD cord-010092-uftc8inx 3807 6 the the DT cord-010092-uftc8inx 3807 7 most most RBS cord-010092-uftc8inx 3807 8 essential essential JJ cord-010092-uftc8inx 3807 9 part part NN cord-010092-uftc8inx 3807 10 of of IN cord-010092-uftc8inx 3807 11 the the DT cord-010092-uftc8inx 3807 12 implementation implementation NN cord-010092-uftc8inx 3807 13 of of IN cord-010092-uftc8inx 3807 14 computerisation computerisation NN cord-010092-uftc8inx 3807 15 who who WP cord-010092-uftc8inx 3807 16 initially initially RB cord-010092-uftc8inx 3807 17 showed show VBD cord-010092-uftc8inx 3807 18 considerable considerable JJ cord-010092-uftc8inx 3807 19 resistance resistance NN cord-010092-uftc8inx 3807 20 and and CC cord-010092-uftc8inx 3807 21 at at IN cord-010092-uftc8inx 3807 22 time time NN cord-010092-uftc8inx 3807 23 faking fake VBG cord-010092-uftc8inx 3807 24 ignorance ignorance NN cord-010092-uftc8inx 3807 25 due due IN cord-010092-uftc8inx 3807 26 to to IN cord-010092-uftc8inx 3807 27 apprehension apprehension NN cord-010092-uftc8inx 3807 28 that that IN cord-010092-uftc8inx 3807 29 their -PRON- PRP$ cord-010092-uftc8inx 3807 30 mistakes mistake NNS cord-010092-uftc8inx 3807 31 will will MD cord-010092-uftc8inx 3807 32 be be VB cord-010092-uftc8inx 3807 33 highlighted highlight VBN cord-010092-uftc8inx 3807 34 and and CC cord-010092-uftc8inx 3807 35 they -PRON- PRP cord-010092-uftc8inx 3807 36 will will MD cord-010092-uftc8inx 3807 37 be be VB cord-010092-uftc8inx 3807 38 penalised penalise VBN cord-010092-uftc8inx 3807 39 for for IN cord-010092-uftc8inx 3807 40 it -PRON- PRP cord-010092-uftc8inx 3807 41 . . . cord-010092-uftc8inx 3808 1 It -PRON- PRP cord-010092-uftc8inx 3808 2 was be VBD cord-010092-uftc8inx 3808 3 a a DT cord-010092-uftc8inx 3808 4 herculean herculean JJ cord-010092-uftc8inx 3808 5 task task NN cord-010092-uftc8inx 3808 6 in in IN cord-010092-uftc8inx 3808 7 creating create VBG cord-010092-uftc8inx 3808 8 their -PRON- PRP$ cord-010092-uftc8inx 3808 9 password password NN cord-010092-uftc8inx 3808 10 protected protect VBN cord-010092-uftc8inx 3808 11 identity identity NN cord-010092-uftc8inx 3808 12 and and CC cord-010092-uftc8inx 3808 13 enforcing enforce VBG cord-010092-uftc8inx 3808 14 them -PRON- PRP cord-010092-uftc8inx 3808 15 to to TO cord-010092-uftc8inx 3808 16 use use VB cord-010092-uftc8inx 3808 17 it -PRON- PRP cord-010092-uftc8inx 3808 18 . . . cord-010092-uftc8inx 3809 1 Gradually gradually RB cord-010092-uftc8inx 3809 2 the the DT cord-010092-uftc8inx 3809 3 staff staff NN cord-010092-uftc8inx 3809 4 realised realise VBD cord-010092-uftc8inx 3809 5 that that IN cord-010092-uftc8inx 3809 6 computerisation computerisation NN cord-010092-uftc8inx 3809 7 made make VBD cord-010092-uftc8inx 3809 8 their -PRON- PRP$ cord-010092-uftc8inx 3809 9 task task NN cord-010092-uftc8inx 3809 10 easier easy JJR cord-010092-uftc8inx 3809 11 as as IN cord-010092-uftc8inx 3809 12 it -PRON- PRP cord-010092-uftc8inx 3809 13 cut cut VBD cord-010092-uftc8inx 3809 14 down down RP cord-010092-uftc8inx 3809 15 on on IN cord-010092-uftc8inx 3809 16 paper paper NN cord-010092-uftc8inx 3809 17 work work NN cord-010092-uftc8inx 3809 18 and and CC cord-010092-uftc8inx 3809 19 repetition repetition NN cord-010092-uftc8inx 3809 20 and and CC cord-010092-uftc8inx 3809 21 also also RB cord-010092-uftc8inx 3809 22 prevented prevent VBD cord-010092-uftc8inx 3809 23 serious serious JJ cord-010092-uftc8inx 3809 24 mistakes mistake NNS cord-010092-uftc8inx 3809 25 from from IN cord-010092-uftc8inx 3809 26 happening happen VBG cord-010092-uftc8inx 3809 27 . . . cord-010092-uftc8inx 3810 1 Hard hard JJ cord-010092-uftc8inx 3810 2 copies copy NNS cord-010092-uftc8inx 3810 3 at at IN cord-010092-uftc8inx 3810 4 certain certain JJ cord-010092-uftc8inx 3810 5 essential essential JJ cord-010092-uftc8inx 3810 6 areas area NNS cord-010092-uftc8inx 3810 7 were be VBD cord-010092-uftc8inx 3810 8 still still RB cord-010092-uftc8inx 3810 9 maintained maintain VBN cord-010092-uftc8inx 3810 10 to to TO cord-010092-uftc8inx 3810 11 continue continue VB cord-010092-uftc8inx 3810 12 work work NN cord-010092-uftc8inx 3810 13 in in IN cord-010092-uftc8inx 3810 14 the the DT cord-010092-uftc8inx 3810 15 event event NN cord-010092-uftc8inx 3810 16 of of IN cord-010092-uftc8inx 3810 17 major major JJ cord-010092-uftc8inx 3810 18 breakdown breakdown NN cord-010092-uftc8inx 3810 19 of of IN cord-010092-uftc8inx 3810 20 computer computer NN cord-010092-uftc8inx 3810 21 Results result NNS cord-010092-uftc8inx 3810 22 : : : cord-010092-uftc8inx 3810 23 Computerisation Computerisation NNP cord-010092-uftc8inx 3810 24 aided aid VBD cord-010092-uftc8inx 3810 25 us -PRON- PRP cord-010092-uftc8inx 3810 26 in in IN cord-010092-uftc8inx 3810 27 regulating regulate VBG cord-010092-uftc8inx 3810 28 the the DT cord-010092-uftc8inx 3810 29 movement movement NN cord-010092-uftc8inx 3810 30 of of IN cord-010092-uftc8inx 3810 31 the the DT cord-010092-uftc8inx 3810 32 donor donor NN cord-010092-uftc8inx 3810 33 which which WDT cord-010092-uftc8inx 3810 34 at at IN cord-010092-uftc8inx 3810 35 times time NNS cord-010092-uftc8inx 3810 36 was be VBD cord-010092-uftc8inx 3810 37 repetitive repetitive JJ cord-010092-uftc8inx 3810 38 due due IN cord-010092-uftc8inx 3810 39 to to IN cord-010092-uftc8inx 3810 40 manual manual JJ cord-010092-uftc8inx 3810 41 entry entry NN cord-010092-uftc8inx 3810 42 . . . cord-010092-uftc8inx 3811 1 Transfer transfer NN cord-010092-uftc8inx 3811 2 of of IN cord-010092-uftc8inx 3811 3 data datum NNS cord-010092-uftc8inx 3811 4 ensured ensure VBD cord-010092-uftc8inx 3811 5 a a DT cord-010092-uftc8inx 3811 6 safe safe JJ cord-010092-uftc8inx 3811 7 supply supply NN cord-010092-uftc8inx 3811 8 and and CC cord-010092-uftc8inx 3811 9 the the DT cord-010092-uftc8inx 3811 10 mistakes mistake NNS cord-010092-uftc8inx 3811 11 could could MD cord-010092-uftc8inx 3811 12 be be VB cord-010092-uftc8inx 3811 13 retraced retrace VBN cord-010092-uftc8inx 3811 14 very very RB cord-010092-uftc8inx 3811 15 easily easily RB cord-010092-uftc8inx 3811 16 . . . cord-010092-uftc8inx 3812 1 Implementation implementation NN cord-010092-uftc8inx 3812 2 which which WDT cord-010092-uftc8inx 3812 3 included include VBD cord-010092-uftc8inx 3812 4 installation installation NN cord-010092-uftc8inx 3812 5 , , , cord-010092-uftc8inx 3812 6 training training NN cord-010092-uftc8inx 3812 7 and and CC cord-010092-uftc8inx 3812 8 enforcement enforcement NN cord-010092-uftc8inx 3812 9 took take VBD cord-010092-uftc8inx 3812 10 a a DT cord-010092-uftc8inx 3812 11 period period NN cord-010092-uftc8inx 3812 12 of of IN cord-010092-uftc8inx 3812 13 6 6 CD cord-010092-uftc8inx 3812 14 months month NNS cord-010092-uftc8inx 3812 15 . . . cord-010092-uftc8inx 3813 1 After after IN cord-010092-uftc8inx 3813 2 overcoming overcome VBG cord-010092-uftc8inx 3813 3 all all PDT cord-010092-uftc8inx 3813 4 the the DT cord-010092-uftc8inx 3813 5 challenges challenge NNS cord-010092-uftc8inx 3813 6 we -PRON- PRP cord-010092-uftc8inx 3813 7 minimised minimise VBD cord-010092-uftc8inx 3813 8 hard hard JJ cord-010092-uftc8inx 3813 9 copies copy NNS cord-010092-uftc8inx 3813 10 to to IN cord-010092-uftc8inx 3813 11 6 6 CD cord-010092-uftc8inx 3813 12 registers register NNS cord-010092-uftc8inx 3813 13 and and CC cord-010092-uftc8inx 3813 14 started start VBD cord-010092-uftc8inx 3813 15 taking take VBG cord-010092-uftc8inx 3813 16 printouts printout NNS cord-010092-uftc8inx 3813 17 of of IN cord-010092-uftc8inx 3813 18 the the DT cord-010092-uftc8inx 3813 19 other other JJ cord-010092-uftc8inx 3813 20 necessary necessary JJ cord-010092-uftc8inx 3813 21 details detail NNS cord-010092-uftc8inx 3813 22 . . . cord-010092-uftc8inx 3814 1 The the DT cord-010092-uftc8inx 3814 2 turnover turnover NN cord-010092-uftc8inx 3814 3 time time NN cord-010092-uftc8inx 3814 4 for for IN cord-010092-uftc8inx 3814 5 the the DT cord-010092-uftc8inx 3814 6 employees employee NNS cord-010092-uftc8inx 3814 7 due due JJ cord-010092-uftc8inx 3814 8 to to IN cord-010092-uftc8inx 3814 9 computerisation computerisation NN cord-010092-uftc8inx 3814 10 decreased decrease VBD cord-010092-uftc8inx 3814 11 by by IN cord-010092-uftc8inx 3814 12 20 20 CD cord-010092-uftc8inx 3814 13 % % NN cord-010092-uftc8inx 3814 14 . . . cord-010092-uftc8inx 3815 1 Waiting wait VBG cord-010092-uftc8inx 3815 2 time time NN cord-010092-uftc8inx 3815 3 for for IN cord-010092-uftc8inx 3815 4 attendant attendant NN cord-010092-uftc8inx 3815 5 decreased decrease VBD cord-010092-uftc8inx 3815 6 by by IN cord-010092-uftc8inx 3815 7 10 10 CD cord-010092-uftc8inx 3815 8 % % NN cord-010092-uftc8inx 3815 9 . . . cord-010092-uftc8inx 3816 1 Traceability traceability NN cord-010092-uftc8inx 3816 2 of of IN cord-010092-uftc8inx 3816 3 all all PDT cord-010092-uftc8inx 3816 4 the the DT cord-010092-uftc8inx 3816 5 units unit NNS cord-010092-uftc8inx 3816 6 became become VBD cord-010092-uftc8inx 3816 7 100%.Supervision 100%.supervision CD cord-010092-uftc8inx 3816 8 of of IN cord-010092-uftc8inx 3816 9 the the DT cord-010092-uftc8inx 3816 10 activities activity NNS cord-010092-uftc8inx 3816 11 being be VBG cord-010092-uftc8inx 3816 12 carried carry VBN cord-010092-uftc8inx 3816 13 out out RP cord-010092-uftc8inx 3816 14 was be VBD cord-010092-uftc8inx 3816 15 90 90 CD cord-010092-uftc8inx 3816 16 % % NN cord-010092-uftc8inx 3816 17 accurate accurate JJ cord-010092-uftc8inx 3816 18 . . . cord-010092-uftc8inx 3817 1 Identification identification NN cord-010092-uftc8inx 3817 2 of of IN cord-010092-uftc8inx 3817 3 the the DT cord-010092-uftc8inx 3817 4 donors donor NNS cord-010092-uftc8inx 3817 5 was be VBD cord-010092-uftc8inx 3817 6 easy easy JJ cord-010092-uftc8inx 3817 7 due due IN cord-010092-uftc8inx 3817 8 to to IN cord-010092-uftc8inx 3817 9 biometrics biometric NNS cord-010092-uftc8inx 3817 10 which which WDT cord-010092-uftc8inx 3817 11 included include VBD cord-010092-uftc8inx 3817 12 thumb thumb NN cord-010092-uftc8inx 3817 13 impression impression NN cord-010092-uftc8inx 3817 14 and and CC cord-010092-uftc8inx 3817 15 iris iris NN cord-010092-uftc8inx 3817 16 scanning scanning NN cord-010092-uftc8inx 3817 17 . . . cord-010092-uftc8inx 3818 1 The the DT cord-010092-uftc8inx 3818 2 decision decision NN cord-010092-uftc8inx 3818 3 making make VBG cord-010092-uftc8inx 3818 4 time time NN cord-010092-uftc8inx 3818 5 for for IN cord-010092-uftc8inx 3818 6 donors donor NNS cord-010092-uftc8inx 3818 7 decreased decrease VBD cord-010092-uftc8inx 3818 8 by by IN cord-010092-uftc8inx 3818 9 50 50 CD cord-010092-uftc8inx 3818 10 % % NN cord-010092-uftc8inx 3818 11 thus thus RB cord-010092-uftc8inx 3818 12 making make VBG cord-010092-uftc8inx 3818 13 the the DT cord-010092-uftc8inx 3818 14 system system NN cord-010092-uftc8inx 3818 15 more more RBR cord-010092-uftc8inx 3818 16 efficient efficient JJ cord-010092-uftc8inx 3818 17 . . . cord-010092-uftc8inx 3819 1 Summary Summary NNP cord-010092-uftc8inx 3819 2 / / SYM cord-010092-uftc8inx 3819 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 3819 4 : : : cord-010092-uftc8inx 3820 1 Manual Manual NNP cord-010092-uftc8inx 3820 2 to to IN cord-010092-uftc8inx 3820 3 computerisation computerisation NN cord-010092-uftc8inx 3820 4 involves involve VBZ cord-010092-uftc8inx 3820 5 involvement involvement NN cord-010092-uftc8inx 3820 6 from from IN cord-010092-uftc8inx 3820 7 source source NN cord-010092-uftc8inx 3820 8 to to TO cord-010092-uftc8inx 3820 9 supply supply VB cord-010092-uftc8inx 3820 10 and and CC cord-010092-uftc8inx 3820 11 it -PRON- PRP cord-010092-uftc8inx 3820 12 is be VBZ cord-010092-uftc8inx 3820 13 essential essential JJ cord-010092-uftc8inx 3820 14 to to TO cord-010092-uftc8inx 3820 15 anticipate anticipate VB cord-010092-uftc8inx 3820 16 the the DT cord-010092-uftc8inx 3820 17 challenges challenge NNS cord-010092-uftc8inx 3820 18 and and CC cord-010092-uftc8inx 3820 19 be be VB cord-010092-uftc8inx 3820 20 prepared prepare VBN cord-010092-uftc8inx 3820 21 for for IN cord-010092-uftc8inx 3820 22 solutions solution NNS cord-010092-uftc8inx 3820 23 in in IN cord-010092-uftc8inx 3820 24 order order NN cord-010092-uftc8inx 3820 25 to to TO cord-010092-uftc8inx 3820 26 make make VB cord-010092-uftc8inx 3820 27 its -PRON- PRP$ cord-010092-uftc8inx 3820 28 implementation implementation NN cord-010092-uftc8inx 3820 29 successful successful JJ cord-010092-uftc8inx 3820 30 P-007 p-007 NN cord-010092-uftc8inx 3820 31 CT CT NNP cord-010092-uftc8inx 3820 32 Smit Smit NNP cord-010092-uftc8inx 3820 33 Sibinga Sibinga NNP cord-010092-uftc8inx 3820 34 1 1 CD cord-010092-uftc8inx 3820 35 , , , cord-010092-uftc8inx 3820 36 Y Y NNP cord-010092-uftc8inx 3820 37 Abdella Abdella NNP cord-010092-uftc8inx 3820 38 2 2 CD cord-010092-uftc8inx 3820 39 and and CC cord-010092-uftc8inx 3820 40 F F NNP cord-010092-uftc8inx 3820 41 Konings Konings NNP cord-010092-uftc8inx 3820 42 2 2 CD cord-010092-uftc8inx 3820 43 1 1 CD cord-010092-uftc8inx 3820 44 IQM IQM NNP cord-010092-uftc8inx 3820 45 Consulting Consulting NNP cord-010092-uftc8inx 3820 46 , , , cord-010092-uftc8inx 3820 47 ZUIDHORN ZUIDHORN NNP cord-010092-uftc8inx 3820 48 , , , cord-010092-uftc8inx 3820 49 Netherlands Netherlands NNP cord-010092-uftc8inx 3820 50 2 2 CD cord-010092-uftc8inx 3820 51 WHO WHO NNP cord-010092-uftc8inx 3820 52 Eastern Eastern NNP cord-010092-uftc8inx 3820 53 Mediterranean Mediterranean NNP cord-010092-uftc8inx 3820 54 Office Office NNP cord-010092-uftc8inx 3820 55 , , , cord-010092-uftc8inx 3820 56 Cairo Cairo NNP cord-010092-uftc8inx 3821 1 , , , cord-010092-uftc8inx 3821 2 Egypt Egypt NNP cord-010092-uftc8inx 3821 3 Background Background NNP cord-010092-uftc8inx 3821 4 : : : cord-010092-uftc8inx 3822 1 WHO who WP cord-010092-uftc8inx 3822 2 defined define VBD cord-010092-uftc8inx 3822 3 essential essential JJ cord-010092-uftc8inx 3822 4 medicines medicine NNS cord-010092-uftc8inx 3822 5 ( ( -LRB- cord-010092-uftc8inx 3822 6 EMs EMs NNP cord-010092-uftc8inx 3822 7 ) ) -RRB- cord-010092-uftc8inx 3822 8 as as IN cord-010092-uftc8inx 3822 9 medicinal medicinal JJ cord-010092-uftc8inx 3822 10 products product NNS cord-010092-uftc8inx 3822 11 that that WDT cord-010092-uftc8inx 3822 12 satisfy satisfy VBP cord-010092-uftc8inx 3822 13 health health NN cord-010092-uftc8inx 3822 14 - - HYPH cord-010092-uftc8inx 3822 15 care care NN cord-010092-uftc8inx 3822 16 needs need NNS cord-010092-uftc8inx 3822 17 of of IN cord-010092-uftc8inx 3822 18 the the DT cord-010092-uftc8inx 3822 19 majority majority NN cord-010092-uftc8inx 3822 20 of of IN cord-010092-uftc8inx 3822 21 a a DT cord-010092-uftc8inx 3822 22 population population NN cord-010092-uftc8inx 3822 23 . . . cord-010092-uftc8inx 3823 1 They -PRON- PRP cord-010092-uftc8inx 3823 2 should should MD cord-010092-uftc8inx 3823 3 be be VB cord-010092-uftc8inx 3823 4 available available JJ cord-010092-uftc8inx 3823 5 at at IN cord-010092-uftc8inx 3823 6 all all DT cord-010092-uftc8inx 3823 7 times time NNS cord-010092-uftc8inx 3823 8 , , , cord-010092-uftc8inx 3823 9 in in IN cord-010092-uftc8inx 3823 10 adequate adequate JJ cord-010092-uftc8inx 3823 11 amounts amount NNS cord-010092-uftc8inx 3823 12 , , , cord-010092-uftc8inx 3823 13 in in IN cord-010092-uftc8inx 3823 14 appropriate appropriate JJ cord-010092-uftc8inx 3823 15 dosage dosage NN cord-010092-uftc8inx 3823 16 forms form NNS cord-010092-uftc8inx 3823 17 , , , cord-010092-uftc8inx 3823 18 with with IN cord-010092-uftc8inx 3823 19 assured assure VBN cord-010092-uftc8inx 3823 20 quality quality NN cord-010092-uftc8inx 3823 21 and and CC cord-010092-uftc8inx 3823 22 affordability affordability NN cord-010092-uftc8inx 3823 23 . . . cord-010092-uftc8inx 3824 1 In in IN cord-010092-uftc8inx 3824 2 2013 2013 CD cord-010092-uftc8inx 3824 3 blood blood NN cord-010092-uftc8inx 3824 4 and and CC cord-010092-uftc8inx 3824 5 blood blood NN cord-010092-uftc8inx 3824 6 products product NNS cord-010092-uftc8inx 3824 7 ( ( -LRB- cord-010092-uftc8inx 3824 8 whole whole JJ cord-010092-uftc8inx 3824 9 blood blood NN cord-010092-uftc8inx 3824 10 , , , cord-010092-uftc8inx 3824 11 red red JJ cord-010092-uftc8inx 3824 12 cells cell NNS cord-010092-uftc8inx 3824 13 , , , cord-010092-uftc8inx 3824 14 platelets platelet NNS cord-010092-uftc8inx 3824 15 , , , cord-010092-uftc8inx 3824 16 plasma plasma NN cord-010092-uftc8inx 3824 17 , , , cord-010092-uftc8inx 3824 18 and and CC cord-010092-uftc8inx 3824 19 plasma plasma NN cord-010092-uftc8inx 3824 20 - - HYPH cord-010092-uftc8inx 3824 21 derived derive VBN cord-010092-uftc8inx 3824 22 products product NNS cord-010092-uftc8inx 3824 23 ) ) -RRB- cord-010092-uftc8inx 3824 24 were be VBD cord-010092-uftc8inx 3824 25 added add VBN cord-010092-uftc8inx 3824 26 to to IN cord-010092-uftc8inx 3824 27 the the DT cord-010092-uftc8inx 3824 28 WHO WHO NNP cord-010092-uftc8inx 3824 29 Model Model NNP cord-010092-uftc8inx 3824 30 List List NNP cord-010092-uftc8inx 3824 31 of of IN cord-010092-uftc8inx 3824 32 EMs EMs NNP cord-010092-uftc8inx 3824 33 . . . cord-010092-uftc8inx 3825 1 Appropriate appropriate JJ cord-010092-uftc8inx 3825 2 and and CC cord-010092-uftc8inx 3825 3 effective effective JJ cord-010092-uftc8inx 3825 4 regulatory regulatory JJ cord-010092-uftc8inx 3825 5 framework framework NN cord-010092-uftc8inx 3825 6 ( ( -LRB- cord-010092-uftc8inx 3825 7 legislations legislation NNS cord-010092-uftc8inx 3825 8 , , , cord-010092-uftc8inx 3825 9 regulations regulation NNS cord-010092-uftc8inx 3825 10 , , , cord-010092-uftc8inx 3825 11 etc etc FW cord-010092-uftc8inx 3825 12 . . . cord-010092-uftc8inx 3825 13 ) ) -RRB- cord-010092-uftc8inx 3825 14 and and CC cord-010092-uftc8inx 3825 15 a a DT cord-010092-uftc8inx 3825 16 functioning function VBG cord-010092-uftc8inx 3825 17 regulatory regulatory JJ cord-010092-uftc8inx 3825 18 authority authority NN cord-010092-uftc8inx 3825 19 ( ( -LRB- cord-010092-uftc8inx 3825 20 RA RA NNP cord-010092-uftc8inx 3825 21 ) ) -RRB- cord-010092-uftc8inx 3825 22 is be VBZ cord-010092-uftc8inx 3825 23 crucial crucial JJ cord-010092-uftc8inx 3825 24 for for IN cord-010092-uftc8inx 3825 25 management management NN cord-010092-uftc8inx 3825 26 of of IN cord-010092-uftc8inx 3825 27 blood blood NN cord-010092-uftc8inx 3825 28 products product NNS cord-010092-uftc8inx 3825 29 as as IN cord-010092-uftc8inx 3825 30 EMs EMs NNP cord-010092-uftc8inx 3825 31 . . . cord-010092-uftc8inx 3826 1 However however RB cord-010092-uftc8inx 3826 2 , , , cord-010092-uftc8inx 3826 3 particularly particularly RB cord-010092-uftc8inx 3826 4 in in IN cord-010092-uftc8inx 3826 5 the the DT cord-010092-uftc8inx 3826 6 less less RBR cord-010092-uftc8inx 3826 7 developed developed JJ cord-010092-uftc8inx 3826 8 world world NN cord-010092-uftc8inx 3826 9 , , , cord-010092-uftc8inx 3826 10 these these DT cord-010092-uftc8inx 3826 11 prerequisites prerequisite NNS cord-010092-uftc8inx 3826 12 have have VBP cord-010092-uftc8inx 3826 13 barely barely RB cord-010092-uftc8inx 3826 14 been be VBN cord-010092-uftc8inx 3826 15 implemented implement VBN cord-010092-uftc8inx 3826 16 . . . cord-010092-uftc8inx 3827 1 Aims aim VBZ cord-010092-uftc8inx 3827 2 : : : cord-010092-uftc8inx 3827 3 To to TO cord-010092-uftc8inx 3827 4 analyze analyze VB cord-010092-uftc8inx 3827 5 and and CC cord-010092-uftc8inx 3827 6 advise advise VB cord-010092-uftc8inx 3827 7 on on IN cord-010092-uftc8inx 3827 8 existing exist VBG cord-010092-uftc8inx 3827 9 legislation legislation NN cord-010092-uftc8inx 3827 10 and and CC cord-010092-uftc8inx 3827 11 regulations regulation NNS cord-010092-uftc8inx 3827 12 . . . cord-010092-uftc8inx 3828 1 Existing exist VBG cord-010092-uftc8inx 3828 2 legislative legislative JJ cord-010092-uftc8inx 3828 3 instruments instrument NNS cord-010092-uftc8inx 3828 4 of of IN cord-010092-uftc8inx 3828 5 the the DT cord-010092-uftc8inx 3828 6 22 22 CD cord-010092-uftc8inx 3828 7 Member Member NNP cord-010092-uftc8inx 3828 8 States States NNP cord-010092-uftc8inx 3828 9 of of IN cord-010092-uftc8inx 3828 10 WHO WHO NNP cord-010092-uftc8inx 3828 11 Eastern Eastern NNP cord-010092-uftc8inx 3828 12 Mediterranean Mediterranean NNP cord-010092-uftc8inx 3828 13 Region Region NNP cord-010092-uftc8inx 3828 14 ( ( -LRB- cord-010092-uftc8inx 3828 15 EMR EMR NNP cord-010092-uftc8inx 3828 16 ) ) -RRB- cord-010092-uftc8inx 3828 17 were be VBD cord-010092-uftc8inx 3828 18 collected collect VBN cord-010092-uftc8inx 3828 19 and and CC cord-010092-uftc8inx 3828 20 analysed analyse VBN cord-010092-uftc8inx 3828 21 for for IN cord-010092-uftc8inx 3828 22 relevance relevance NN cord-010092-uftc8inx 3828 23 and and CC cord-010092-uftc8inx 3828 24 appropriateness appropriateness NN cord-010092-uftc8inx 3828 25 for for IN cord-010092-uftc8inx 3828 26 preparation preparation NN cord-010092-uftc8inx 3828 27 and and CC cord-010092-uftc8inx 3828 28 use use NN cord-010092-uftc8inx 3828 29 of of IN cord-010092-uftc8inx 3828 30 blood blood NN cord-010092-uftc8inx 3828 31 and and CC cord-010092-uftc8inx 3828 32 blood blood NN cord-010092-uftc8inx 3828 33 products product NNS cord-010092-uftc8inx 3828 34 as as RB cord-010092-uftc8inx 3828 35 well well RB cord-010092-uftc8inx 3828 36 as as IN cord-010092-uftc8inx 3828 37 use use NN cord-010092-uftc8inx 3828 38 of of IN cord-010092-uftc8inx 3828 39 associated associate VBN cord-010092-uftc8inx 3828 40 substances substance NNS cord-010092-uftc8inx 3828 41 and and CC cord-010092-uftc8inx 3828 42 relevant relevant JJ cord-010092-uftc8inx 3828 43 medical medical JJ cord-010092-uftc8inx 3828 44 devices device NNS cord-010092-uftc8inx 3828 45 . . . cord-010092-uftc8inx 3829 1 A a DT cord-010092-uftc8inx 3829 2 literature literature NN cord-010092-uftc8inx 3829 3 search search NN cord-010092-uftc8inx 3829 4 was be VBD cord-010092-uftc8inx 3829 5 done do VBN cord-010092-uftc8inx 3829 6 on on IN cord-010092-uftc8inx 3829 7 matching match VBG cord-010092-uftc8inx 3829 8 combinations combination NNS cord-010092-uftc8inx 3829 9 of of IN cord-010092-uftc8inx 3829 10 regulatory regulatory JJ cord-010092-uftc8inx 3829 11 system system NN cord-010092-uftc8inx 3829 12 , , , cord-010092-uftc8inx 3829 13 regulatory regulatory JJ cord-010092-uftc8inx 3829 14 framework framework NN cord-010092-uftc8inx 3829 15 , , , cord-010092-uftc8inx 3829 16 legislation legislation NN cord-010092-uftc8inx 3829 17 , , , cord-010092-uftc8inx 3829 18 regulation regulation NN cord-010092-uftc8inx 3829 19 , , , cord-010092-uftc8inx 3829 20 with with IN cord-010092-uftc8inx 3829 21 production production NN cord-010092-uftc8inx 3829 22 and and CC cord-010092-uftc8inx 3829 23 use use NN cord-010092-uftc8inx 3829 24 of of IN cord-010092-uftc8inx 3829 25 blood blood NN cord-010092-uftc8inx 3829 26 and and CC cord-010092-uftc8inx 3829 27 blood blood NN cord-010092-uftc8inx 3829 28 products product NNS cord-010092-uftc8inx 3829 29 , , , cord-010092-uftc8inx 3829 30 which which WDT cord-010092-uftc8inx 3829 31 resulted result VBD cord-010092-uftc8inx 3829 32 in in IN cord-010092-uftc8inx 3829 33 almost almost RB cord-010092-uftc8inx 3829 34 exclusively exclusively RB cord-010092-uftc8inx 3829 35 references reference NNS cord-010092-uftc8inx 3829 36 with with IN cord-010092-uftc8inx 3829 37 respect respect NN cord-010092-uftc8inx 3829 38 to to IN cord-010092-uftc8inx 3829 39 national national JJ cord-010092-uftc8inx 3829 40 and and CC cord-010092-uftc8inx 3829 41 international international JJ cord-010092-uftc8inx 3829 42 legislation legislation NN cord-010092-uftc8inx 3829 43 . . . cord-010092-uftc8inx 3830 1 Benchmark benchmark NN cord-010092-uftc8inx 3830 2 : : : cord-010092-uftc8inx 3831 1 WHO who WP cord-010092-uftc8inx 3831 2 recommendations recommendation VBZ cord-010092-uftc8inx 3831 3 ( ( -LRB- cord-010092-uftc8inx 3831 4 Aide Aide NNP cord-010092-uftc8inx 3831 5 M M NNP cord-010092-uftc8inx 3831 6 emoires emoires NNPS cord-010092-uftc8inx 3831 7 ) ) -RRB- cord-010092-uftc8inx 3831 8 and and CC cord-010092-uftc8inx 3831 9 EU EU NNP cord-010092-uftc8inx 3831 10 Directives Directives NNPS cord-010092-uftc8inx 3831 11 . . . cord-010092-uftc8inx 3832 1 Methods method NNS cord-010092-uftc8inx 3832 2 : : : cord-010092-uftc8inx 3832 3 Existing exist VBG cord-010092-uftc8inx 3832 4 legislative legislative JJ cord-010092-uftc8inx 3832 5 instruments instrument NNS cord-010092-uftc8inx 3832 6 of of IN cord-010092-uftc8inx 3832 7 the the DT cord-010092-uftc8inx 3832 8 22 22 CD cord-010092-uftc8inx 3832 9 Member Member NNP cord-010092-uftc8inx 3832 10 States States NNP cord-010092-uftc8inx 3832 11 of of IN cord-010092-uftc8inx 3832 12 WHO WHO NNP cord-010092-uftc8inx 3832 13 Eastern Eastern NNP cord-010092-uftc8inx 3832 14 Mediterranean Mediterranean NNP cord-010092-uftc8inx 3832 15 Region Region NNP cord-010092-uftc8inx 3832 16 ( ( -LRB- cord-010092-uftc8inx 3832 17 EMR EMR NNP cord-010092-uftc8inx 3832 18 ) ) -RRB- cord-010092-uftc8inx 3832 19 were be VBD cord-010092-uftc8inx 3832 20 collected collect VBN cord-010092-uftc8inx 3832 21 and and CC cord-010092-uftc8inx 3832 22 analysed analyse VBN cord-010092-uftc8inx 3832 23 for for IN cord-010092-uftc8inx 3832 24 relevance relevance NN cord-010092-uftc8inx 3832 25 and and CC cord-010092-uftc8inx 3832 26 appropriateness appropriateness NN cord-010092-uftc8inx 3832 27 for for IN cord-010092-uftc8inx 3832 28 preparation preparation NN cord-010092-uftc8inx 3832 29 and and CC cord-010092-uftc8inx 3832 30 use use NN cord-010092-uftc8inx 3832 31 of of IN cord-010092-uftc8inx 3832 32 blood blood NN cord-010092-uftc8inx 3832 33 and and CC cord-010092-uftc8inx 3832 34 blood blood NN cord-010092-uftc8inx 3832 35 products product NNS cord-010092-uftc8inx 3832 36 as as RB cord-010092-uftc8inx 3832 37 well well RB cord-010092-uftc8inx 3832 38 as as IN cord-010092-uftc8inx 3832 39 use use NN cord-010092-uftc8inx 3832 40 of of IN cord-010092-uftc8inx 3832 41 associated associate VBN cord-010092-uftc8inx 3832 42 substances substance NNS cord-010092-uftc8inx 3832 43 and and CC cord-010092-uftc8inx 3832 44 relevant relevant JJ cord-010092-uftc8inx 3832 45 medical medical JJ cord-010092-uftc8inx 3832 46 devices device NNS cord-010092-uftc8inx 3832 47 . . . cord-010092-uftc8inx 3833 1 A a DT cord-010092-uftc8inx 3833 2 literature literature NN cord-010092-uftc8inx 3833 3 search search NN cord-010092-uftc8inx 3833 4 was be VBD cord-010092-uftc8inx 3833 5 done do VBN cord-010092-uftc8inx 3833 6 on on IN cord-010092-uftc8inx 3833 7 matching match VBG cord-010092-uftc8inx 3833 8 combinations combination NNS cord-010092-uftc8inx 3833 9 of of IN cord-010092-uftc8inx 3833 10 regulatory regulatory JJ cord-010092-uftc8inx 3833 11 system system NN cord-010092-uftc8inx 3833 12 , , , cord-010092-uftc8inx 3833 13 regulatory regulatory JJ cord-010092-uftc8inx 3833 14 framework framework NN cord-010092-uftc8inx 3833 15 , , , cord-010092-uftc8inx 3833 16 legislation legislation NN cord-010092-uftc8inx 3833 17 , , , cord-010092-uftc8inx 3833 18 regulation regulation NN cord-010092-uftc8inx 3833 19 , , , cord-010092-uftc8inx 3833 20 with with IN cord-010092-uftc8inx 3833 21 production production NN cord-010092-uftc8inx 3833 22 and and CC cord-010092-uftc8inx 3833 23 use use NN cord-010092-uftc8inx 3833 24 of of IN cord-010092-uftc8inx 3833 25 blood blood NN cord-010092-uftc8inx 3833 26 and and CC cord-010092-uftc8inx 3833 27 blood blood NN cord-010092-uftc8inx 3833 28 products product NNS cord-010092-uftc8inx 3833 29 , , , cord-010092-uftc8inx 3833 30 which which WDT cord-010092-uftc8inx 3833 31 resulted result VBD cord-010092-uftc8inx 3833 32 in in IN cord-010092-uftc8inx 3833 33 almost almost RB cord-010092-uftc8inx 3833 34 exclusively exclusively RB cord-010092-uftc8inx 3833 35 references reference NNS cord-010092-uftc8inx 3833 36 with with IN cord-010092-uftc8inx 3833 37 respect respect NN cord-010092-uftc8inx 3833 38 to to IN cord-010092-uftc8inx 3833 39 national national JJ cord-010092-uftc8inx 3833 40 and and CC cord-010092-uftc8inx 3833 41 international international JJ cord-010092-uftc8inx 3833 42 legislation legislation NN cord-010092-uftc8inx 3833 43 . . . cord-010092-uftc8inx 3834 1 Benchmark benchmark NN cord-010092-uftc8inx 3834 2 : : : cord-010092-uftc8inx 3835 1 WHO who WP cord-010092-uftc8inx 3835 2 recommendations recommendation VBZ cord-010092-uftc8inx 3835 3 ( ( -LRB- cord-010092-uftc8inx 3835 4 Aide Aide NNP cord-010092-uftc8inx 3835 5 M M NNP cord-010092-uftc8inx 3835 6 emoires emoires NNPS cord-010092-uftc8inx 3835 7 ) ) -RRB- cord-010092-uftc8inx 3835 8 and and CC cord-010092-uftc8inx 3835 9 EU EU NNP cord-010092-uftc8inx 3835 10 Directives Directives NNPS cord-010092-uftc8inx 3835 11 . . . cord-010092-uftc8inx 3836 1 Results result NNS cord-010092-uftc8inx 3836 2 : : : cord-010092-uftc8inx 3837 1 Various various JJ cord-010092-uftc8inx 3837 2 formal formal JJ cord-010092-uftc8inx 3837 3 legislative legislative JJ cord-010092-uftc8inx 3837 4 documents document NNS cord-010092-uftc8inx 3837 5 of of IN cord-010092-uftc8inx 3837 6 only only RB cord-010092-uftc8inx 3837 7 9/22 9/22 CD cord-010092-uftc8inx 3837 8 countries country NNS cord-010092-uftc8inx 3837 9 are be VBP cord-010092-uftc8inx 3837 10 put put VBN cord-010092-uftc8inx 3837 11 in in IN cord-010092-uftc8inx 3837 12 force force NN cord-010092-uftc8inx 3837 13 by by IN cord-010092-uftc8inx 3837 14 Governments government NNS cord-010092-uftc8inx 3837 15 [ [ -LRB- cord-010092-uftc8inx 3837 16 1960 1960 CD cord-010092-uftc8inx 3837 17 ( ( -LRB- cord-010092-uftc8inx 3837 18 Egypt Egypt NNP cord-010092-uftc8inx 3837 19 ) ) -RRB- cord-010092-uftc8inx 3837 20 till till IN cord-010092-uftc8inx 3837 21 2017 2017 CD cord-010092-uftc8inx 3838 1 ( ( -LRB- cord-010092-uftc8inx 3838 2 Pakistan Pakistan NNP cord-010092-uftc8inx 3838 3 -Sindh -Sindh NNP cord-010092-uftc8inx 3838 4 ) ) -RRB- cord-010092-uftc8inx 3838 5 ] ] -RRB- cord-010092-uftc8inx 3838 6 . . . cord-010092-uftc8inx 3839 1 Most Most JJS cord-010092-uftc8inx 3839 2 are be VBP cord-010092-uftc8inx 3839 3 detailed detailed JJ cord-010092-uftc8inx 3839 4 descriptions description NNS cord-010092-uftc8inx 3839 5 of of IN cord-010092-uftc8inx 3839 6 RA RA NNP cord-010092-uftc8inx 3839 7 , , , cord-010092-uftc8inx 3839 8 operational operational JJ cord-010092-uftc8inx 3839 9 establishments establishment NNS cord-010092-uftc8inx 3839 10 , , , cord-010092-uftc8inx 3839 11 and and CC cord-010092-uftc8inx 3839 12 specific specific JJ cord-010092-uftc8inx 3839 13 requirements requirement NNS cord-010092-uftc8inx 3839 14 . . . cord-010092-uftc8inx 3840 1 However however RB cord-010092-uftc8inx 3840 2 , , , cord-010092-uftc8inx 3840 3 none none NN cord-010092-uftc8inx 3840 4 of of IN cord-010092-uftc8inx 3840 5 these these DT cord-010092-uftc8inx 3840 6 legislations legislation NNS cord-010092-uftc8inx 3840 7 complies comply VBZ cord-010092-uftc8inx 3840 8 with with IN cord-010092-uftc8inx 3840 9 WHO WHO NNP cord-010092-uftc8inx 3840 10 and and CC cord-010092-uftc8inx 3840 11 EU EU NNP cord-010092-uftc8inx 3840 12 recommended recommend VBD cord-010092-uftc8inx 3840 13 formats format NNS cord-010092-uftc8inx 3840 14 and and CC cord-010092-uftc8inx 3840 15 contents content NNS cord-010092-uftc8inx 3840 16 , , , cord-010092-uftc8inx 3840 17 and and CC cord-010092-uftc8inx 3840 18 will will MD cord-010092-uftc8inx 3840 19 not not RB cord-010092-uftc8inx 3840 20 support support VB cord-010092-uftc8inx 3840 21 effective effective JJ cord-010092-uftc8inx 3840 22 regulatory regulatory JJ cord-010092-uftc8inx 3840 23 oversight oversight NN cord-010092-uftc8inx 3840 24 to to TO cord-010092-uftc8inx 3840 25 promote promote VB cord-010092-uftc8inx 3840 26 and and CC cord-010092-uftc8inx 3840 27 enhance enhance VB cord-010092-uftc8inx 3840 28 quality quality NN cord-010092-uftc8inx 3840 29 , , , cord-010092-uftc8inx 3840 30 safety safety NN cord-010092-uftc8inx 3840 31 and and CC cord-010092-uftc8inx 3840 32 availability availability NN cord-010092-uftc8inx 3840 33 of of IN cord-010092-uftc8inx 3840 34 these these DT cord-010092-uftc8inx 3840 35 EMs em NNS cord-010092-uftc8inx 3840 36 . . . cord-010092-uftc8inx 3841 1 Summary Summary NNP cord-010092-uftc8inx 3841 2 / / SYM cord-010092-uftc8inx 3841 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 3841 4 : : : cord-010092-uftc8inx 3842 1 Government government NN cord-010092-uftc8inx 3842 2 should should MD cord-010092-uftc8inx 3842 3 provide provide VB cord-010092-uftc8inx 3842 4 effective effective JJ cord-010092-uftc8inx 3842 5 leadership leadership NN cord-010092-uftc8inx 3842 6 and and CC cord-010092-uftc8inx 3842 7 governance governance NN cord-010092-uftc8inx 3842 8 in in IN cord-010092-uftc8inx 3842 9 developing develop VBG cord-010092-uftc8inx 3842 10 a a DT cord-010092-uftc8inx 3842 11 national national JJ cord-010092-uftc8inx 3842 12 blood blood NN cord-010092-uftc8inx 3842 13 system system NN cord-010092-uftc8inx 3842 14 ( ( -LRB- cord-010092-uftc8inx 3842 15 NBS NBS NNP cord-010092-uftc8inx 3842 16 , , , cord-010092-uftc8inx 3842 17 fully fully RB cord-010092-uftc8inx 3842 18 integrated integrate VBN cord-010092-uftc8inx 3842 19 into into IN cord-010092-uftc8inx 3842 20 the the DT cord-010092-uftc8inx 3842 21 national national JJ cord-010092-uftc8inx 3842 22 health health NN cord-010092-uftc8inx 3842 23 - - HYPH cord-010092-uftc8inx 3842 24 care care NN cord-010092-uftc8inx 3842 25 system system NN cord-010092-uftc8inx 3842 26 . . . cord-010092-uftc8inx 3843 1 Essential essential JJ cord-010092-uftc8inx 3843 2 functions function NNS cord-010092-uftc8inx 3843 3 of of IN cord-010092-uftc8inx 3843 4 a a DT cord-010092-uftc8inx 3843 5 NBS NBS NNP cord-010092-uftc8inx 3843 6 include include VBP cord-010092-uftc8inx 3843 7 an an DT cord-010092-uftc8inx 3843 8 appropriate appropriate JJ cord-010092-uftc8inx 3843 9 regulatory regulatory JJ cord-010092-uftc8inx 3843 10 framework framework NN cord-010092-uftc8inx 3843 11 with with IN cord-010092-uftc8inx 3843 12 legislations legislation NNS cord-010092-uftc8inx 3843 13 , , , cord-010092-uftc8inx 3843 14 regulations regulation NNS cord-010092-uftc8inx 3843 15 and and CC cord-010092-uftc8inx 3843 16 other other JJ cord-010092-uftc8inx 3843 17 non non JJ cord-010092-uftc8inx 3843 18 - - JJ cord-010092-uftc8inx 3843 19 legislative legislative JJ cord-010092-uftc8inx 3843 20 instruments instrument NNS cord-010092-uftc8inx 3843 21 administered administer VBN cord-010092-uftc8inx 3843 22 by by IN cord-010092-uftc8inx 3843 23 a a DT cord-010092-uftc8inx 3843 24 RA RA NNP cord-010092-uftc8inx 3843 25 . . . cord-010092-uftc8inx 3844 1 These these DT cord-010092-uftc8inx 3844 2 documents document NNS cord-010092-uftc8inx 3844 3 should should MD cord-010092-uftc8inx 3844 4 spell spell VB cord-010092-uftc8inx 3844 5 out out RP cord-010092-uftc8inx 3844 6 principles principle NNS cord-010092-uftc8inx 3844 7 and and CC cord-010092-uftc8inx 3844 8 cadres cadre NNS cord-010092-uftc8inx 3844 9 , , , cord-010092-uftc8inx 3844 10 standard standard JJ cord-010092-uftc8inx 3844 11 setting setting NN cord-010092-uftc8inx 3844 12 , , , cord-010092-uftc8inx 3844 13 and and CC cord-010092-uftc8inx 3844 14 organization organization NN cord-010092-uftc8inx 3844 15 of of IN cord-010092-uftc8inx 3844 16 the the DT cord-010092-uftc8inx 3844 17 blood blood NN cord-010092-uftc8inx 3844 18 system system NN cord-010092-uftc8inx 3844 19 to to TO cord-010092-uftc8inx 3844 20 ensure ensure VB cord-010092-uftc8inx 3844 21 an an DT cord-010092-uftc8inx 3844 22 adequate adequate JJ cord-010092-uftc8inx 3844 23 supply supply NN cord-010092-uftc8inx 3844 24 of of IN cord-010092-uftc8inx 3844 25 blood blood NN cord-010092-uftc8inx 3844 26 and and CC cord-010092-uftc8inx 3844 27 blood blood NN cord-010092-uftc8inx 3844 28 products product NNS cord-010092-uftc8inx 3844 29 and and CC cord-010092-uftc8inx 3844 30 safe safe JJ cord-010092-uftc8inx 3844 31 clinical clinical JJ cord-010092-uftc8inx 3844 32 transfusion transfusion NN cord-010092-uftc8inx 3844 33 for for IN cord-010092-uftc8inx 3844 34 which which WDT cord-010092-uftc8inx 3844 35 a a DT cord-010092-uftc8inx 3844 36 Model Model NNP cord-010092-uftc8inx 3844 37 was be VBD cord-010092-uftc8inx 3844 38 designed design VBN cord-010092-uftc8inx 3844 39 . . . cord-010092-uftc8inx 3845 1 The the DT cord-010092-uftc8inx 3845 2 structure structure NN cord-010092-uftc8inx 3845 3 of of IN cord-010092-uftc8inx 3845 4 NBS NBS NNP cord-010092-uftc8inx 3845 5 will will MD cord-010092-uftc8inx 3845 6 depend depend VB cord-010092-uftc8inx 3845 7 on on IN cord-010092-uftc8inx 3845 8 organization organization NN cord-010092-uftc8inx 3845 9 and and CC cord-010092-uftc8inx 3845 10 level level NN cord-010092-uftc8inx 3845 11 of of IN cord-010092-uftc8inx 3845 12 development development NN cord-010092-uftc8inx 3845 13 of of IN cord-010092-uftc8inx 3845 14 the the DT cord-010092-uftc8inx 3845 15 health health NN cord-010092-uftc8inx 3845 16 - - HYPH cord-010092-uftc8inx 3845 17 care care NN cord-010092-uftc8inx 3845 18 system system NN cord-010092-uftc8inx 3845 19 . . . cord-010092-uftc8inx 3846 1 However however RB cord-010092-uftc8inx 3846 2 , , , cord-010092-uftc8inx 3846 3 all all DT cord-010092-uftc8inx 3846 4 critical critical JJ cord-010092-uftc8inx 3846 5 activities activity NNS cord-010092-uftc8inx 3846 6 within within IN cord-010092-uftc8inx 3846 7 NBS NBS NNP cord-010092-uftc8inx 3846 8 should should MD cord-010092-uftc8inx 3846 9 be be VB cord-010092-uftc8inx 3846 10 coordinated coordinate VBN cord-010092-uftc8inx 3846 11 nationally nationally RB cord-010092-uftc8inx 3846 12 to to TO cord-010092-uftc8inx 3846 13 promote promote VB cord-010092-uftc8inx 3846 14 uniform uniform JJ cord-010092-uftc8inx 3846 15 standards standard NNS cord-010092-uftc8inx 3846 16 , , , cord-010092-uftc8inx 3846 17 economies economy NNS cord-010092-uftc8inx 3846 18 - - HYPH cord-010092-uftc8inx 3846 19 of of IN cord-010092-uftc8inx 3846 20 - - HYPH cord-010092-uftc8inx 3846 21 scale scale NN cord-010092-uftc8inx 3846 22 , , , cord-010092-uftc8inx 3846 23 consistency consistency NN cord-010092-uftc8inx 3846 24 in in IN cord-010092-uftc8inx 3846 25 staff staff NN cord-010092-uftc8inx 3846 26 competency competency NN cord-010092-uftc8inx 3846 27 , , , cord-010092-uftc8inx 3846 28 quality quality NN cord-010092-uftc8inx 3846 29 and and CC cord-010092-uftc8inx 3846 30 safety safety NN cord-010092-uftc8inx 3846 31 of of IN cord-010092-uftc8inx 3846 32 these these DT cord-010092-uftc8inx 3846 33 EMs em NNS cord-010092-uftc8inx 3846 34 , , , cord-010092-uftc8inx 3846 35 and and CC cord-010092-uftc8inx 3846 36 best good JJS cord-010092-uftc8inx 3846 37 transfusion transfusion NN cord-010092-uftc8inx 3846 38 practices practice NNS cord-010092-uftc8inx 3846 39 . . . cord-010092-uftc8inx 3847 1 Key Key NNP cord-010092-uftc8inx 3847 2 is be VBZ cord-010092-uftc8inx 3847 3 formulation formulation NN cord-010092-uftc8inx 3847 4 of of IN cord-010092-uftc8inx 3847 5 an an DT cord-010092-uftc8inx 3847 6 appropriate appropriate JJ cord-010092-uftc8inx 3847 7 regulatory regulatory JJ cord-010092-uftc8inx 3847 8 framework framework NN cord-010092-uftc8inx 3847 9 administered administer VBN cord-010092-uftc8inx 3847 10 by by IN cord-010092-uftc8inx 3847 11 a a DT cord-010092-uftc8inx 3847 12 RA RA NNP cord-010092-uftc8inx 3847 13 responsible responsible JJ cord-010092-uftc8inx 3847 14 for for IN cord-010092-uftc8inx 3847 15 regulating regulate VBG cord-010092-uftc8inx 3847 16 the the DT cord-010092-uftc8inx 3847 17 vein vein NN cord-010092-uftc8inx 3847 18 - - HYPH cord-010092-uftc8inx 3847 19 to to IN cord-010092-uftc8inx 3847 20 - - HYPH cord-010092-uftc8inx 3847 21 vein vein NN cord-010092-uftc8inx 3847 22 chain chain NN cord-010092-uftc8inx 3847 23 in in IN cord-010092-uftc8inx 3847 24 the the DT cord-010092-uftc8inx 3847 25 preparation preparation NN cord-010092-uftc8inx 3847 26 and and CC cord-010092-uftc8inx 3847 27 use use NN cord-010092-uftc8inx 3847 28 of of IN cord-010092-uftc8inx 3847 29 these these DT cord-010092-uftc8inx 3847 30 EMs em NNS cord-010092-uftc8inx 3847 31 . . . cord-010092-uftc8inx 3848 1 Background background NN cord-010092-uftc8inx 3848 2 : : : cord-010092-uftc8inx 3849 1 The the DT cord-010092-uftc8inx 3849 2 capacity capacity NN cord-010092-uftc8inx 3849 3 of of IN cord-010092-uftc8inx 3849 4 blood blood NN cord-010092-uftc8inx 3849 5 transfusion transfusion NN cord-010092-uftc8inx 3849 6 service service NN cord-010092-uftc8inx 3849 7 to to TO cord-010092-uftc8inx 3849 8 provide provide VB cord-010092-uftc8inx 3849 9 adequate adequate JJ cord-010092-uftc8inx 3849 10 supplies supply NNS cord-010092-uftc8inx 3849 11 of of IN cord-010092-uftc8inx 3849 12 blood blood NN cord-010092-uftc8inx 3849 13 components component NNS cord-010092-uftc8inx 3849 14 is be VBZ cord-010092-uftc8inx 3849 15 the the DT cord-010092-uftc8inx 3849 16 issue issue NN cord-010092-uftc8inx 3849 17 of of IN cord-010092-uftc8inx 3849 18 concern concern NN cord-010092-uftc8inx 3849 19 for for IN cord-010092-uftc8inx 3849 20 health health NN cord-010092-uftc8inx 3849 21 providers provider NNS cord-010092-uftc8inx 3849 22 worldwide worldwide RB cord-010092-uftc8inx 3849 23 ; ; : cord-010092-uftc8inx 3849 24 longer long JJR cord-010092-uftc8inx 3849 25 term term NN cord-010092-uftc8inx 3849 26 observations observation NNS cord-010092-uftc8inx 3849 27 of of IN cord-010092-uftc8inx 3849 28 trends trend NNS cord-010092-uftc8inx 3849 29 in in IN cord-010092-uftc8inx 3849 30 this this DT cord-010092-uftc8inx 3849 31 respect respect NN cord-010092-uftc8inx 3849 32 are be VBP cord-010092-uftc8inx 3849 33 therefore therefore RB cord-010092-uftc8inx 3849 34 of of IN cord-010092-uftc8inx 3849 35 crucial crucial JJ cord-010092-uftc8inx 3849 36 value value NN cord-010092-uftc8inx 3849 37 . . . cord-010092-uftc8inx 3850 1 Aims aim VBZ cord-010092-uftc8inx 3850 2 : : : cord-010092-uftc8inx 3851 1 The the DT cord-010092-uftc8inx 3851 2 study study NN cord-010092-uftc8inx 3851 3 aim aim NN cord-010092-uftc8inx 3851 4 was be VBD cord-010092-uftc8inx 3851 5 analysis analysis NN cord-010092-uftc8inx 3851 6 of of IN cord-010092-uftc8inx 3851 7 some some DT cord-010092-uftc8inx 3851 8 basic basic JJ cord-010092-uftc8inx 3851 9 activities activity NNS cord-010092-uftc8inx 3851 10 of of IN cord-010092-uftc8inx 3851 11 the the DT cord-010092-uftc8inx 3851 12 Polish Polish NNP cord-010092-uftc8inx 3851 13 Blood Blood NNP cord-010092-uftc8inx 3851 14 Transfusion Transfusion NNP cord-010092-uftc8inx 3851 15 Service Service NNP cord-010092-uftc8inx 3851 16 in in IN cord-010092-uftc8inx 3851 17 2008 2008 CD cord-010092-uftc8inx 3851 18 - - SYM cord-010092-uftc8inx 3851 19 2017 2017 CD cord-010092-uftc8inx 3851 20 including include VBG cord-010092-uftc8inx 3851 21 organizational organizational JJ cord-010092-uftc8inx 3851 22 changes change NNS cord-010092-uftc8inx 3851 23 , , , cord-010092-uftc8inx 3851 24 numbers number NNS cord-010092-uftc8inx 3851 25 of of IN cord-010092-uftc8inx 3851 26 donors donor NNS cord-010092-uftc8inx 3851 27 , , , cord-010092-uftc8inx 3851 28 donations donation NNS cord-010092-uftc8inx 3851 29 and and CC cord-010092-uftc8inx 3851 30 blood blood NN cord-010092-uftc8inx 3851 31 components component NNS cord-010092-uftc8inx 3851 32 as as RB cord-010092-uftc8inx 3851 33 well well RB cord-010092-uftc8inx 3851 34 as as IN cord-010092-uftc8inx 3851 35 activities activity NNS cord-010092-uftc8inx 3851 36 directed direct VBN cord-010092-uftc8inx 3851 37 at at IN cord-010092-uftc8inx 3851 38 increasing increase VBG cord-010092-uftc8inx 3851 39 their -PRON- PRP$ cord-010092-uftc8inx 3851 40 safety safety NN cord-010092-uftc8inx 3851 41 . . . cord-010092-uftc8inx 3852 1 Methods method NNS cord-010092-uftc8inx 3852 2 : : : cord-010092-uftc8inx 3853 1 Retrospective retrospective JJ cord-010092-uftc8inx 3853 2 analysis analysis NN cord-010092-uftc8inx 3853 3 of of IN cord-010092-uftc8inx 3853 4 data datum NNS cord-010092-uftc8inx 3853 5 supplied supply VBN cord-010092-uftc8inx 3853 6 by by IN cord-010092-uftc8inx 3853 7 the the DT cord-010092-uftc8inx 3853 8 regional regional JJ cord-010092-uftc8inx 3853 9 Blood Blood NNP cord-010092-uftc8inx 3853 10 Transfusion Transfusion NNP cord-010092-uftc8inx 3853 11 Centers Centers NNPS cord-010092-uftc8inx 3853 12 ( ( -LRB- cord-010092-uftc8inx 3853 13 BTCs BTCs NNP cord-010092-uftc8inx 3853 14 ) ) -RRB- cord-010092-uftc8inx 3853 15 . . . cord-010092-uftc8inx 3854 1 Results result NNS cord-010092-uftc8inx 3854 2 : : : cord-010092-uftc8inx 3855 1 In in IN cord-010092-uftc8inx 3855 2 the the DT cord-010092-uftc8inx 3855 3 discussed discuss VBN cord-010092-uftc8inx 3855 4 period period NN cord-010092-uftc8inx 3855 5 , , , cord-010092-uftc8inx 3855 6 blood blood NN cord-010092-uftc8inx 3855 7 and and CC cord-010092-uftc8inx 3855 8 blood blood NN cord-010092-uftc8inx 3855 9 components component NNS cord-010092-uftc8inx 3855 10 were be VBD cord-010092-uftc8inx 3855 11 collected collect VBN cord-010092-uftc8inx 3855 12 in in IN cord-010092-uftc8inx 3855 13 21 21 CD cord-010092-uftc8inx 3855 14 regional regional JJ cord-010092-uftc8inx 3855 15 BTCs btc NNS cord-010092-uftc8inx 3855 16 and and CC cord-010092-uftc8inx 3855 17 local local JJ cord-010092-uftc8inx 3855 18 collection collection NN cord-010092-uftc8inx 3855 19 sites site NNS cord-010092-uftc8inx 3855 20 as as RB cord-010092-uftc8inx 3855 21 well well RB cord-010092-uftc8inx 3855 22 as as IN cord-010092-uftc8inx 3855 23 during during IN cord-010092-uftc8inx 3855 24 mobile mobile JJ cord-010092-uftc8inx 3855 25 collections collection NNS cord-010092-uftc8inx 3855 26 . . . cord-010092-uftc8inx 3856 1 Although although IN cord-010092-uftc8inx 3856 2 the the DT cord-010092-uftc8inx 3856 3 number number NN cord-010092-uftc8inx 3856 4 of of IN cord-010092-uftc8inx 3856 5 local local JJ cord-010092-uftc8inx 3856 6 collection collection NN cord-010092-uftc8inx 3856 7 sites site NNS cord-010092-uftc8inx 3856 8 decreased decrease VBD cord-010092-uftc8inx 3856 9 from from IN cord-010092-uftc8inx 3856 10 170 170 CD cord-010092-uftc8inx 3856 11 in in IN cord-010092-uftc8inx 3856 12 2008 2008 CD cord-010092-uftc8inx 3856 13 to to IN cord-010092-uftc8inx 3856 14 133 133 CD cord-010092-uftc8inx 3856 15 in in IN cord-010092-uftc8inx 3856 16 2017 2017 CD cord-010092-uftc8inx 3856 17 in in IN cord-010092-uftc8inx 3856 18 favor favor NN cord-010092-uftc8inx 3856 19 of of IN cord-010092-uftc8inx 3856 20 mobile mobile JJ cord-010092-uftc8inx 3856 21 collections collection NNS cord-010092-uftc8inx 3856 22 , , , cord-010092-uftc8inx 3856 23 which which WDT cord-010092-uftc8inx 3856 24 increased increase VBD cord-010092-uftc8inx 3856 25 from from IN cord-010092-uftc8inx 3856 26 8,672 8,672 CD cord-010092-uftc8inx 3856 27 to to IN cord-010092-uftc8inx 3856 28 13,189 13,189 CD cord-010092-uftc8inx 3856 29 , , , cord-010092-uftc8inx 3856 30 the the DT cord-010092-uftc8inx 3856 31 former former JJ cord-010092-uftc8inx 3856 32 is be VBZ cord-010092-uftc8inx 3856 33 still still RB cord-010092-uftc8inx 3856 34 the the DT cord-010092-uftc8inx 3856 35 number number NN cord-010092-uftc8inx 3856 36 one one CD cord-010092-uftc8inx 3856 37 location location NN cord-010092-uftc8inx 3856 38 for for IN cord-010092-uftc8inx 3856 39 donating donate VBG cord-010092-uftc8inx 3856 40 blood blood NN cord-010092-uftc8inx 3856 41 . . . cord-010092-uftc8inx 3857 1 On on IN cord-010092-uftc8inx 3857 2 average average JJ cord-010092-uftc8inx 3857 3 47.36 47.36 CD cord-010092-uftc8inx 3857 4 % % NN cord-010092-uftc8inx 3857 5 of of IN cord-010092-uftc8inx 3857 6 all all DT cord-010092-uftc8inx 3857 7 donations donation NNS cord-010092-uftc8inx 3857 8 were be VBD cord-010092-uftc8inx 3857 9 performed perform VBN cord-010092-uftc8inx 3857 10 in in IN cord-010092-uftc8inx 3857 11 local local JJ cord-010092-uftc8inx 3857 12 collection collection NN cord-010092-uftc8inx 3857 13 sites site NNS cord-010092-uftc8inx 3857 14 . . . cord-010092-uftc8inx 3858 1 The the DT cord-010092-uftc8inx 3858 2 total total JJ cord-010092-uftc8inx 3858 3 number number NN cord-010092-uftc8inx 3858 4 of of IN cord-010092-uftc8inx 3858 5 blood blood NN cord-010092-uftc8inx 3858 6 donors donor NNS cord-010092-uftc8inx 3858 7 both both CC cord-010092-uftc8inx 3858 8 at at IN cord-010092-uftc8inx 3858 9 the the DT cord-010092-uftc8inx 3858 10 beginning beginning NN cord-010092-uftc8inx 3858 11 and and CC cord-010092-uftc8inx 3858 12 the the DT cord-010092-uftc8inx 3858 13 end end NN cord-010092-uftc8inx 3858 14 of of IN cord-010092-uftc8inx 3858 15 the the DT cord-010092-uftc8inx 3858 16 discussed discuss VBN cord-010092-uftc8inx 3858 17 period period NN cord-010092-uftc8inx 3858 18 was be VBD cord-010092-uftc8inx 3858 19 similar similar JJ cord-010092-uftc8inx 3858 20 ( ( -LRB- cord-010092-uftc8inx 3858 21 583,908 583,908 CD cord-010092-uftc8inx 3858 22 in in IN cord-010092-uftc8inx 3858 23 2008 2008 CD cord-010092-uftc8inx 3858 24 and and CC cord-010092-uftc8inx 3858 25 588,184 588,184 CD cord-010092-uftc8inx 3858 26 in in IN cord-010092-uftc8inx 3858 27 2017 2017 CD cord-010092-uftc8inx 3858 28 ) ) -RRB- cord-010092-uftc8inx 3858 29 ; ; : cord-010092-uftc8inx 3858 30 over over IN cord-010092-uftc8inx 3858 31 99 99 CD cord-010092-uftc8inx 3858 32 % % NN cord-010092-uftc8inx 3858 33 of of IN cord-010092-uftc8inx 3858 34 all all DT cord-010092-uftc8inx 3858 35 donors donor NNS cord-010092-uftc8inx 3858 36 were be VBD cord-010092-uftc8inx 3858 37 non non JJ cord-010092-uftc8inx 3858 38 - - JJ cord-010092-uftc8inx 3858 39 remunerated remunerated JJ cord-010092-uftc8inx 3858 40 . . . cord-010092-uftc8inx 3859 1 However however RB cord-010092-uftc8inx 3859 2 , , , cord-010092-uftc8inx 3859 3 the the DT cord-010092-uftc8inx 3859 4 number number NN cord-010092-uftc8inx 3859 5 of of IN cord-010092-uftc8inx 3859 6 first first JJ cord-010092-uftc8inx 3859 7 - - HYPH cord-010092-uftc8inx 3859 8 time time NN cord-010092-uftc8inx 3859 9 donors donor NNS cord-010092-uftc8inx 3859 10 dropped drop VBD cord-010092-uftc8inx 3859 11 significantly significantly RB cord-010092-uftc8inx 3859 12 ( ( -LRB- cord-010092-uftc8inx 3859 13 from from IN cord-010092-uftc8inx 3859 14 237,658 237,658 CD cord-010092-uftc8inx 3859 15 in in IN cord-010092-uftc8inx 3859 16 2008 2008 CD cord-010092-uftc8inx 3859 17 to to IN cord-010092-uftc8inx 3859 18 143,038 143,038 CD cord-010092-uftc8inx 3859 19 in in IN cord-010092-uftc8inx 3859 20 2017 2017 CD cord-010092-uftc8inx 3859 21 ) ) -RRB- cord-010092-uftc8inx 3859 22 . . . cord-010092-uftc8inx 3860 1 The the DT cord-010092-uftc8inx 3860 2 total total JJ cord-010092-uftc8inx 3860 3 number number NN cord-010092-uftc8inx 3860 4 of of IN cord-010092-uftc8inx 3860 5 donations donation NNS cord-010092-uftc8inx 3860 6 increased increase VBD cord-010092-uftc8inx 3860 7 from from IN cord-010092-uftc8inx 3860 8 1,076,655 1,076,655 CD cord-010092-uftc8inx 3860 9 in in IN cord-010092-uftc8inx 3860 10 2008 2008 CD cord-010092-uftc8inx 3860 11 to to IN cord-010092-uftc8inx 3860 12 1,249,655 1,249,655 CD cord-010092-uftc8inx 3860 13 in in IN cord-010092-uftc8inx 3860 14 2017 2017 CD cord-010092-uftc8inx 3860 15 ; ; : cord-010092-uftc8inx 3860 16 most most RBS cord-010092-uftc8inx 3860 17 frequent frequent JJ cord-010092-uftc8inx 3860 18 were be VBD cord-010092-uftc8inx 3860 19 whole whole JJ cord-010092-uftc8inx 3860 20 blood blood NN cord-010092-uftc8inx 3860 21 collections collection NNS cord-010092-uftc8inx 3860 22 ( ( -LRB- cord-010092-uftc8inx 3860 23 from from IN cord-010092-uftc8inx 3860 24 1,016,411 1,016,411 CD cord-010092-uftc8inx 3860 25 in in IN cord-010092-uftc8inx 3860 26 2008 2008 CD cord-010092-uftc8inx 3860 27 to to IN cord-010092-uftc8inx 3860 28 1,171,302 1,171,302 CD cord-010092-uftc8inx 3860 29 in in IN cord-010092-uftc8inx 3860 30 2017 2017 CD cord-010092-uftc8inx 3860 31 ) ) -RRB- cord-010092-uftc8inx 3860 32 . . . cord-010092-uftc8inx 3861 1 Some some DT cord-010092-uftc8inx 3861 2 blood blood NN cord-010092-uftc8inx 3861 3 components component NNS cord-010092-uftc8inx 3861 4 ( ( -LRB- cord-010092-uftc8inx 3861 5 mostly mostly RB cord-010092-uftc8inx 3861 6 plasma plasma NN cord-010092-uftc8inx 3861 7 and and CC cord-010092-uftc8inx 3861 8 platelet platelet NN cord-010092-uftc8inx 3861 9 concentrates concentrate NNS cord-010092-uftc8inx 3861 10 ) ) -RRB- cord-010092-uftc8inx 3861 11 were be VBD cord-010092-uftc8inx 3861 12 also also RB cord-010092-uftc8inx 3861 13 collected collect VBN cord-010092-uftc8inx 3861 14 by by IN cord-010092-uftc8inx 3861 15 apheresis apheresis NN cord-010092-uftc8inx 3861 16 . . . cord-010092-uftc8inx 3862 1 Most most RBS cord-010092-uftc8inx 3862 2 frequently frequently RB cord-010092-uftc8inx 3862 3 prepared prepare VBD cord-010092-uftc8inx 3862 4 blood blood NN cord-010092-uftc8inx 3862 5 components component NNS cord-010092-uftc8inx 3862 6 were be VBD cord-010092-uftc8inx 3863 1 red red JJ cord-010092-uftc8inx 3863 2 blood blood NN cord-010092-uftc8inx 3863 3 cell cell NN cord-010092-uftc8inx 3863 4 concentrates concentrate VBZ cord-010092-uftc8inx 3863 5 -RBCs -RBCs : cord-010092-uftc8inx 3863 6 ( ( -LRB- cord-010092-uftc8inx 3863 7 996,678 996,678 CD cord-010092-uftc8inx 3863 8 - - SYM cord-010092-uftc8inx 3863 9 1,154,239 1,154,239 CD cord-010092-uftc8inx 3863 10 units unit NNS cord-010092-uftc8inx 3863 11 per per IN cord-010092-uftc8inx 3863 12 year year NN cord-010092-uftc8inx 3863 13 ) ) -RRB- cord-010092-uftc8inx 3863 14 , , , cord-010092-uftc8inx 3863 15 fresh fresh JJ cord-010092-uftc8inx 3863 16 frozen frozen JJ cord-010092-uftc8inx 3863 17 plasma plasma NN cord-010092-uftc8inx 3863 18 -FFP -FFP . cord-010092-uftc8inx 3863 19 ( ( -LRB- cord-010092-uftc8inx 3863 20 1,090,369 1,090,369 CD cord-010092-uftc8inx 3863 21 - - SYM cord-010092-uftc8inx 3863 22 1,289,021 1,289,021 CD cord-010092-uftc8inx 3863 23 units unit NNS cord-010092-uftc8inx 3863 24 ) ) -RRB- cord-010092-uftc8inx 3863 25 and and CC cord-010092-uftc8inx 3863 26 platelet platelet NN cord-010092-uftc8inx 3863 27 concentrates concentrate VBZ cord-010092-uftc8inx 3864 1 -PCs -PCs NFP cord-010092-uftc8inx 3865 1 ( ( -LRB- cord-010092-uftc8inx 3865 2 81,692 81,692 CD cord-010092-uftc8inx 3865 3 - - SYM cord-010092-uftc8inx 3865 4 129,143 129,143 CD cord-010092-uftc8inx 3865 5 units unit NNS cord-010092-uftc8inx 3865 6 , , , cord-010092-uftc8inx 3865 7 with with IN cord-010092-uftc8inx 3865 8 significant significant JJ cord-010092-uftc8inx 3865 9 increasing increasing JJ cord-010092-uftc8inx 3865 10 tendency tendency NN cord-010092-uftc8inx 3865 11 ) ) -RRB- cord-010092-uftc8inx 3865 12 . . . cord-010092-uftc8inx 3866 1 Additional additional JJ cord-010092-uftc8inx 3866 2 processing processing NN cord-010092-uftc8inx 3866 3 methods method NNS cord-010092-uftc8inx 3866 4 such such JJ cord-010092-uftc8inx 3866 5 as as IN cord-010092-uftc8inx 3866 6 leukocyte leukocyte NN cord-010092-uftc8inx 3866 7 depletion depletion NN cord-010092-uftc8inx 3866 8 and and CC cord-010092-uftc8inx 3866 9 irradiation irradiation NN cord-010092-uftc8inx 3866 10 were be VBD cord-010092-uftc8inx 3866 11 more more RBR cord-010092-uftc8inx 3866 12 frequently frequently RB cord-010092-uftc8inx 3866 13 applied apply VBN cord-010092-uftc8inx 3866 14 to to IN cord-010092-uftc8inx 3866 15 PCs pc NNS cord-010092-uftc8inx 3866 16 ( ( -LRB- cord-010092-uftc8inx 3866 17 52 52 CD cord-010092-uftc8inx 3866 18 - - SYM cord-010092-uftc8inx 3866 19 57.6 57.6 CD cord-010092-uftc8inx 3866 20 % % NN cord-010092-uftc8inx 3866 21 in in IN cord-010092-uftc8inx 3866 22 respective respective JJ cord-010092-uftc8inx 3866 23 years year NNS cord-010092-uftc8inx 3866 24 irradiated irradiate VBN cord-010092-uftc8inx 3866 25 , , , cord-010092-uftc8inx 3866 26 75.18 75.18 CD cord-010092-uftc8inx 3866 27 - - SYM cord-010092-uftc8inx 3866 28 92.07 92.07 CD cord-010092-uftc8inx 3866 29 % % NN cord-010092-uftc8inx 3866 30 leukocyte leukocyte NN cord-010092-uftc8inx 3866 31 - - HYPH cord-010092-uftc8inx 3866 32 depleted deplete VBN cord-010092-uftc8inx 3866 33 ) ) -RRB- cord-010092-uftc8inx 3866 34 , , , cord-010092-uftc8inx 3866 35 than than IN cord-010092-uftc8inx 3866 36 to to IN cord-010092-uftc8inx 3866 37 RBCs rbc NNS cord-010092-uftc8inx 3866 38 ( ( -LRB- cord-010092-uftc8inx 3866 39 4.46 4.46 CD cord-010092-uftc8inx 3866 40 - - SYM cord-010092-uftc8inx 3866 41 8.46 8.46 CD cord-010092-uftc8inx 3866 42 % % NN cord-010092-uftc8inx 3866 43 irradiated irradiate VBN cord-010092-uftc8inx 3866 44 , , , cord-010092-uftc8inx 3866 45 7.65 7.65 CD cord-010092-uftc8inx 3866 46 - - SYM cord-010092-uftc8inx 3866 47 20.7 20.7 CD cord-010092-uftc8inx 3866 48 % % NN cord-010092-uftc8inx 3866 49 leukocyte leukocyte NN cord-010092-uftc8inx 3866 50 - - HYPH cord-010092-uftc8inx 3866 51 depleted deplete VBN cord-010092-uftc8inx 3866 52 ) ) -RRB- cord-010092-uftc8inx 3866 53 . . . cord-010092-uftc8inx 3867 1 In in IN cord-010092-uftc8inx 3867 2 2010 2010 CD cord-010092-uftc8inx 3867 3 , , , cord-010092-uftc8inx 3867 4 the the DT cord-010092-uftc8inx 3867 5 pathogen pathogen NN cord-010092-uftc8inx 3867 6 reduction reduction NN cord-010092-uftc8inx 3867 7 technologies technology NNS cord-010092-uftc8inx 3867 8 in in IN cord-010092-uftc8inx 3867 9 plasma plasma NN cord-010092-uftc8inx 3867 10 and and CC cord-010092-uftc8inx 3867 11 the the DT cord-010092-uftc8inx 3867 12 PCs pc NNS cord-010092-uftc8inx 3867 13 were be VBD cord-010092-uftc8inx 3867 14 implemented implement VBN cord-010092-uftc8inx 3867 15 . . . cord-010092-uftc8inx 3868 1 Up up IN cord-010092-uftc8inx 3868 2 to to IN cord-010092-uftc8inx 3868 3 date date NN cord-010092-uftc8inx 3868 4 however however RB cord-010092-uftc8inx 3868 5 the the DT cord-010092-uftc8inx 3868 6 use use NN cord-010092-uftc8inx 3868 7 of of IN cord-010092-uftc8inx 3868 8 these these DT cord-010092-uftc8inx 3868 9 technologies technology NNS cord-010092-uftc8inx 3868 10 is be VBZ cord-010092-uftc8inx 3868 11 limited limit VBN cord-010092-uftc8inx 3868 12 in in IN cord-010092-uftc8inx 3868 13 most most JJS cord-010092-uftc8inx 3868 14 BTCs btc NNS cord-010092-uftc8inx 3868 15 . . . cord-010092-uftc8inx 3869 1 In in IN cord-010092-uftc8inx 3869 2 2017 2017 CD cord-010092-uftc8inx 3869 3 approximately approximately RB cord-010092-uftc8inx 3869 4 11.5 11.5 CD cord-010092-uftc8inx 3869 5 % % NN cord-010092-uftc8inx 3869 6 of of IN cord-010092-uftc8inx 3869 7 PCs pc NNS cord-010092-uftc8inx 3869 8 and and CC cord-010092-uftc8inx 3869 9 8 8 CD cord-010092-uftc8inx 3869 10 % % NN cord-010092-uftc8inx 3869 11 FFP FFP NNP cord-010092-uftc8inx 3869 12 units unit NNS cord-010092-uftc8inx 3869 13 issued issue VBN cord-010092-uftc8inx 3869 14 for for IN cord-010092-uftc8inx 3869 15 transfusion transfusion NN cord-010092-uftc8inx 3869 16 were be VBD cord-010092-uftc8inx 3869 17 subjected subject VBN cord-010092-uftc8inx 3869 18 to to IN cord-010092-uftc8inx 3869 19 pathogen pathogen NN cord-010092-uftc8inx 3869 20 reduction reduction NN cord-010092-uftc8inx 3869 21 technologies technology NNS cord-010092-uftc8inx 3869 22 . . . cord-010092-uftc8inx 3870 1 Summary Summary NNP cord-010092-uftc8inx 3870 2 / / SYM cord-010092-uftc8inx 3870 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 3870 4 : : : cord-010092-uftc8inx 3871 1 Our -PRON- PRP$ cord-010092-uftc8inx 3871 2 study study NN cord-010092-uftc8inx 3871 3 data datum NNS cord-010092-uftc8inx 3871 4 may may MD cord-010092-uftc8inx 3871 5 contribute contribute VB cord-010092-uftc8inx 3871 6 to to IN cord-010092-uftc8inx 3871 7 the the DT cord-010092-uftc8inx 3871 8 assessment assessment NN cord-010092-uftc8inx 3871 9 of of IN cord-010092-uftc8inx 3871 10 some some DT cord-010092-uftc8inx 3871 11 long long JJ cord-010092-uftc8inx 3871 12 - - HYPH cord-010092-uftc8inx 3871 13 term term NN cord-010092-uftc8inx 3871 14 tendencies tendency NNS cord-010092-uftc8inx 3871 15 observed observe VBN cord-010092-uftc8inx 3871 16 in in IN cord-010092-uftc8inx 3871 17 Polish Polish NNP cord-010092-uftc8inx 3871 18 Blood Blood NNP cord-010092-uftc8inx 3871 19 Transfusion Transfusion NNP cord-010092-uftc8inx 3871 20 Service Service NNP cord-010092-uftc8inx 3871 21 and and CC cord-010092-uftc8inx 3871 22 may may MD cord-010092-uftc8inx 3871 23 serve serve VB cord-010092-uftc8inx 3871 24 practical practical JJ cord-010092-uftc8inx 3871 25 - - HYPH cord-010092-uftc8inx 3871 26 benchmarking benchmarking NN cord-010092-uftc8inx 3871 27 . . . cord-010092-uftc8inx 3872 1 This this DT cord-010092-uftc8inx 3872 2 in in IN cord-010092-uftc8inx 3872 3 turn turn NN cord-010092-uftc8inx 3872 4 may may MD cord-010092-uftc8inx 3872 5 prove prove VB cord-010092-uftc8inx 3872 6 beneficial beneficial JJ cord-010092-uftc8inx 3872 7 to to IN cord-010092-uftc8inx 3872 8 the the DT cord-010092-uftc8inx 3872 9 transfusion transfusion NN cord-010092-uftc8inx 3872 10 community community NN cord-010092-uftc8inx 3872 11 as as IN cord-010092-uftc8inx 3872 12 a a DT cord-010092-uftc8inx 3872 13 whole whole NN cord-010092-uftc8inx 3872 14 . . . cord-010092-uftc8inx 3873 1 Background background NN cord-010092-uftc8inx 3873 2 : : : cord-010092-uftc8inx 3874 1 In in IN cord-010092-uftc8inx 3874 2 Poland Poland NNP cord-010092-uftc8inx 3874 3 80 80 CD cord-010092-uftc8inx 3874 4 % % NN cord-010092-uftc8inx 3874 5 of of IN cord-010092-uftc8inx 3874 6 hospitals hospital NNS cord-010092-uftc8inx 3874 7 depend depend VBP cord-010092-uftc8inx 3874 8 on on IN cord-010092-uftc8inx 3874 9 blood blood NN cord-010092-uftc8inx 3874 10 for for IN cord-010092-uftc8inx 3874 11 the the DT cord-010092-uftc8inx 3874 12 treatment treatment NN cord-010092-uftc8inx 3874 13 of of IN cord-010092-uftc8inx 3874 14 patients patient NNS cord-010092-uftc8inx 3874 15 ; ; : cord-010092-uftc8inx 3874 16 over over IN cord-010092-uftc8inx 3874 17 1.5 1.5 CD cord-010092-uftc8inx 3874 18 mln mln NNS cord-010092-uftc8inx 3874 19 units unit NNS cord-010092-uftc8inx 3874 20 of of IN cord-010092-uftc8inx 3874 21 blood blood NN cord-010092-uftc8inx 3874 22 components component NNS cord-010092-uftc8inx 3874 23 are be VBP cord-010092-uftc8inx 3874 24 annually annually RB cord-010092-uftc8inx 3874 25 transfused transfuse VBN cord-010092-uftc8inx 3874 26 . . . cord-010092-uftc8inx 3875 1 It -PRON- PRP cord-010092-uftc8inx 3875 2 is be VBZ cord-010092-uftc8inx 3875 3 therefore therefore RB cord-010092-uftc8inx 3875 4 purposeful purposeful JJ cord-010092-uftc8inx 3875 5 to to TO cord-010092-uftc8inx 3875 6 expand expand VB cord-010092-uftc8inx 3875 7 the the DT cord-010092-uftc8inx 3875 8 knowledge knowledge NN cord-010092-uftc8inx 3875 9 on on IN cord-010092-uftc8inx 3875 10 factors factor NNS cord-010092-uftc8inx 3875 11 impacting impact VBG cord-010092-uftc8inx 3875 12 on on IN cord-010092-uftc8inx 3875 13 blood blood NN cord-010092-uftc8inx 3875 14 transfusion transfusion NN cord-010092-uftc8inx 3875 15 service service NN cord-010092-uftc8inx 3875 16 ( ( -LRB- cord-010092-uftc8inx 3875 17 BTS BTS NNP cord-010092-uftc8inx 3875 18 ) ) -RRB- cord-010092-uftc8inx 3875 19 . . . cord-010092-uftc8inx 3876 1 The the DT cord-010092-uftc8inx 3876 2 Institute Institute NNP cord-010092-uftc8inx 3876 3 of of IN cord-010092-uftc8inx 3876 4 Hematology Hematology NNP cord-010092-uftc8inx 3876 5 and and CC cord-010092-uftc8inx 3876 6 Transfusion Transfusion NNP cord-010092-uftc8inx 3876 7 Medicine Medicine NNP cord-010092-uftc8inx 3876 8 ( ( -LRB- cord-010092-uftc8inx 3876 9 IHTM IHTM NNP cord-010092-uftc8inx 3876 10 ) ) -RRB- cord-010092-uftc8inx 3876 11 as as IN cord-010092-uftc8inx 3876 12 competent competent JJ cord-010092-uftc8inx 3876 13 authority authority NN cord-010092-uftc8inx 3876 14 is be VBZ cord-010092-uftc8inx 3876 15 responsible responsible JJ cord-010092-uftc8inx 3876 16 for for IN cord-010092-uftc8inx 3876 17 collection collection NN cord-010092-uftc8inx 3876 18 of of IN cord-010092-uftc8inx 3876 19 data datum NNS cord-010092-uftc8inx 3876 20 related relate VBN cord-010092-uftc8inx 3876 21 to to IN cord-010092-uftc8inx 3876 22 the the DT cord-010092-uftc8inx 3876 23 activity activity NN cord-010092-uftc8inx 3876 24 of of IN cord-010092-uftc8inx 3876 25 all all DT cord-010092-uftc8inx 3876 26 Polish Polish NNP cord-010092-uftc8inx 3876 27 Blood Blood NNP cord-010092-uftc8inx 3876 28 Transfusion Transfusion NNP cord-010092-uftc8inx 3876 29 Centers Centers NNPS cord-010092-uftc8inx 3876 30 ( ( -LRB- cord-010092-uftc8inx 3876 31 BCTs BCTs NNP cord-010092-uftc8inx 3876 32 ) ) -RRB- cord-010092-uftc8inx 3876 33 . . . cord-010092-uftc8inx 3877 1 This this DT cord-010092-uftc8inx 3877 2 data data NN cord-010092-uftc8inx 3877 3 is be VBZ cord-010092-uftc8inx 3877 4 exploited exploit VBN cord-010092-uftc8inx 3877 5 to to IN cord-010092-uftc8inx 3877 6 a a DT cord-010092-uftc8inx 3877 7 much much RB cord-010092-uftc8inx 3877 8 lesser less JJR cord-010092-uftc8inx 3877 9 degree degree NN cord-010092-uftc8inx 3877 10 than than IN cord-010092-uftc8inx 3877 11 the the DT cord-010092-uftc8inx 3877 12 recently recently RB cord-010092-uftc8inx 3877 13 available available JJ cord-010092-uftc8inx 3877 14 statistical statistical JJ cord-010092-uftc8inx 3877 15 methods method NNS cord-010092-uftc8inx 3877 16 and and CC cord-010092-uftc8inx 3877 17 data data NN cord-010092-uftc8inx 3877 18 processing processing NN cord-010092-uftc8inx 3877 19 tools tool NNS cord-010092-uftc8inx 3877 20 would would MD cord-010092-uftc8inx 3877 21 allow allow VB cord-010092-uftc8inx 3877 22 . . . cord-010092-uftc8inx 3878 1 Moreover moreover RB cord-010092-uftc8inx 3878 2 , , , cord-010092-uftc8inx 3878 3 survey survey NN cord-010092-uftc8inx 3878 4 of of IN cord-010092-uftc8inx 3878 5 research research NN cord-010092-uftc8inx 3878 6 in in IN cord-010092-uftc8inx 3878 7 the the DT cord-010092-uftc8inx 3878 8 field field NN cord-010092-uftc8inx 3878 9 of of IN cord-010092-uftc8inx 3878 10 public public JJ cord-010092-uftc8inx 3878 11 health health NN cord-010092-uftc8inx 3878 12 indicates indicate VBZ cord-010092-uftc8inx 3878 13 a a DT cord-010092-uftc8inx 3878 14 negligible negligible JJ cord-010092-uftc8inx 3878 15 share share NN cord-010092-uftc8inx 3878 16 of of IN cord-010092-uftc8inx 3878 17 issues issue NNS cord-010092-uftc8inx 3878 18 related relate VBN cord-010092-uftc8inx 3878 19 to to IN cord-010092-uftc8inx 3878 20 BTS BTS NNP cord-010092-uftc8inx 3878 21 . . . cord-010092-uftc8inx 3879 1 It -PRON- PRP cord-010092-uftc8inx 3879 2 seemed seem VBD cord-010092-uftc8inx 3879 3 therefore therefore RB cord-010092-uftc8inx 3879 4 necessary necessary JJ cord-010092-uftc8inx 3879 5 to to TO cord-010092-uftc8inx 3879 6 " " `` cord-010092-uftc8inx 3879 7 fill fill VB cord-010092-uftc8inx 3879 8 in in RP cord-010092-uftc8inx 3879 9 the the DT cord-010092-uftc8inx 3879 10 gap gap NN cord-010092-uftc8inx 3879 11 " " '' cord-010092-uftc8inx 3879 12 with with IN cord-010092-uftc8inx 3879 13 true true JJ cord-010092-uftc8inx 3879 14 assessment assessment NN cord-010092-uftc8inx 3879 15 of of IN cord-010092-uftc8inx 3879 16 performance performance NN cord-010092-uftc8inx 3879 17 of of IN cord-010092-uftc8inx 3879 18 the the DT cord-010092-uftc8inx 3879 19 Polish polish JJ cord-010092-uftc8inx 3879 20 BCTs bct NNS cord-010092-uftc8inx 3879 21 for for IN cord-010092-uftc8inx 3879 22 improvement improvement NN cord-010092-uftc8inx 3879 23 of of IN cord-010092-uftc8inx 3879 24 BTS bts NN cord-010092-uftc8inx 3879 25 activity activity NN cord-010092-uftc8inx 3879 26 . . . cord-010092-uftc8inx 3880 1 1 1 CD cord-010092-uftc8inx 3880 2 st st NNP cord-010092-uftc8inx 3880 3 stage stage NN cord-010092-uftc8inx 3880 4 of of IN cord-010092-uftc8inx 3880 5 our -PRON- PRP$ cord-010092-uftc8inx 3880 6 investigation investigation NN cord-010092-uftc8inx 3880 7 refers refer VBZ cord-010092-uftc8inx 3880 8 to to IN cord-010092-uftc8inx 3880 9 collection collection NN cord-010092-uftc8inx 3880 10 , , , cord-010092-uftc8inx 3880 11 merging merge VBG cord-010092-uftc8inx 3880 12 of of IN cord-010092-uftc8inx 3880 13 data datum NNS cord-010092-uftc8inx 3880 14 from from IN cord-010092-uftc8inx 3880 15 different different JJ cord-010092-uftc8inx 3880 16 sources source NNS cord-010092-uftc8inx 3880 17 , , , cord-010092-uftc8inx 3880 18 their -PRON- PRP$ cord-010092-uftc8inx 3880 19 unification unification NN cord-010092-uftc8inx 3880 20 and and CC cord-010092-uftc8inx 3880 21 preparation preparation NN cord-010092-uftc8inx 3880 22 ( ( -LRB- cord-010092-uftc8inx 3880 23 big big JJ cord-010092-uftc8inx 3880 24 data datum NNS cord-010092-uftc8inx 3880 25 ) ) -RRB- cord-010092-uftc8inx 3880 26 for for IN cord-010092-uftc8inx 3880 27 further further JJ cord-010092-uftc8inx 3880 28 analysis analysis NN cord-010092-uftc8inx 3880 29 to to TO cord-010092-uftc8inx 3880 30 be be VB cord-010092-uftc8inx 3880 31 performed perform VBN cord-010092-uftc8inx 3880 32 using use VBG cord-010092-uftc8inx 3880 33 multidimensional multidimensional JJ cord-010092-uftc8inx 3880 34 statistical statistical JJ cord-010092-uftc8inx 3880 35 analysis analysis NN cord-010092-uftc8inx 3880 36 and and CC cord-010092-uftc8inx 3880 37 data data NN cord-010092-uftc8inx 3880 38 mining mining NN cord-010092-uftc8inx 3880 39 methods method NNS cord-010092-uftc8inx 3880 40 . . . cord-010092-uftc8inx 3881 1 Aims aim VBZ cord-010092-uftc8inx 3881 2 : : : cord-010092-uftc8inx 3881 3 Assessment assessment NN cord-010092-uftc8inx 3881 4 of of IN cord-010092-uftc8inx 3881 5 the the DT cord-010092-uftc8inx 3881 6 activity activity NN cord-010092-uftc8inx 3881 7 of of IN cord-010092-uftc8inx 3881 8 the the DT cord-010092-uftc8inx 3881 9 Polish polish JJ cord-010092-uftc8inx 3881 10 BTCs btc NNS cord-010092-uftc8inx 3881 11 over over IN cord-010092-uftc8inx 3881 12 the the DT cord-010092-uftc8inx 3881 13 20 20 CD cord-010092-uftc8inx 3881 14 year year NN cord-010092-uftc8inx 3881 15 - - HYPH cord-010092-uftc8inx 3881 16 period period NN cord-010092-uftc8inx 3881 17 in in IN cord-010092-uftc8inx 3881 18 two two CD cord-010092-uftc8inx 3881 19 stages stage NNS cord-010092-uftc8inx 3881 20 . . . cord-010092-uftc8inx 3882 1 Goals goal NNS cord-010092-uftc8inx 3882 2 at at IN cord-010092-uftc8inx 3882 3 1 1 CD cord-010092-uftc8inx 3882 4 st st NNP cord-010092-uftc8inx 3882 5 stage stage NN cord-010092-uftc8inx 3882 6 : : : cord-010092-uftc8inx 3882 7 1 1 CD cord-010092-uftc8inx 3882 8 . . . cord-010092-uftc8inx 3883 1 Data data NN cord-010092-uftc8inx 3883 2 digitalization digitalization NN cord-010092-uftc8inx 3883 3 ; ; : cord-010092-uftc8inx 3883 4 scanning scanning NN cord-010092-uftc8inx 3883 5 of of IN cord-010092-uftc8inx 3883 6 paper paper NN cord-010092-uftc8inx 3883 7 documents document NNS cord-010092-uftc8inx 3883 8 . . . cord-010092-uftc8inx 3884 1 2 2 LS cord-010092-uftc8inx 3884 2 . . . cord-010092-uftc8inx 3885 1 Development development NN cord-010092-uftc8inx 3885 2 of of IN cord-010092-uftc8inx 3885 3 a a DT cord-010092-uftc8inx 3885 4 uniform uniform JJ cord-010092-uftc8inx 3885 5 template template NN cord-010092-uftc8inx 3885 6 for for IN cord-010092-uftc8inx 3885 7 collecting collect VBG cord-010092-uftc8inx 3885 8 digital digital JJ cord-010092-uftc8inx 3885 9 data datum NNS cord-010092-uftc8inx 3885 10 from from IN cord-010092-uftc8inx 3885 11 various various JJ cord-010092-uftc8inx 3885 12 sources source NNS cord-010092-uftc8inx 3885 13 . . . cord-010092-uftc8inx 3886 1 3 3 LS cord-010092-uftc8inx 3886 2 . . . cord-010092-uftc8inx 3887 1 Standardization standardization NN cord-010092-uftc8inx 3887 2 , , , cord-010092-uftc8inx 3887 3 unification unification NN cord-010092-uftc8inx 3887 4 and and CC cord-010092-uftc8inx 3887 5 quality quality NN cord-010092-uftc8inx 3887 6 improvement improvement NN cord-010092-uftc8inx 3887 7 of of IN cord-010092-uftc8inx 3887 8 available available JJ cord-010092-uftc8inx 3887 9 data datum NNS cord-010092-uftc8inx 3887 10 : : : cord-010092-uftc8inx 3887 11 filling fill VBG cord-010092-uftc8inx 3887 12 in in RP cord-010092-uftc8inx 3887 13 missing miss VBG cord-010092-uftc8inx 3887 14 data datum NNS cord-010092-uftc8inx 3887 15 , , , cord-010092-uftc8inx 3887 16 elimination elimination NN cord-010092-uftc8inx 3887 17 of of IN cord-010092-uftc8inx 3887 18 errors error NNS cord-010092-uftc8inx 3887 19 , , , cord-010092-uftc8inx 3887 20 duplicate duplicate VB cord-010092-uftc8inx 3887 21 records record NNS cord-010092-uftc8inx 3887 22 etc etc FW cord-010092-uftc8inx 3888 1 , , , cord-010092-uftc8inx 3888 2 that that DT cord-010092-uftc8inx 3888 3 may may MD cord-010092-uftc8inx 3888 4 distort distort VB cord-010092-uftc8inx 3888 5 the the DT cord-010092-uftc8inx 3888 6 outcome outcome NN cord-010092-uftc8inx 3888 7 of of IN cord-010092-uftc8inx 3888 8 analyzes analyze NNS cord-010092-uftc8inx 3888 9 . . . cord-010092-uftc8inx 3889 1 4 4 LS cord-010092-uftc8inx 3889 2 . . . cord-010092-uftc8inx 3890 1 Selection selection NN cord-010092-uftc8inx 3890 2 of of IN cord-010092-uftc8inx 3890 3 data datum NNS cord-010092-uftc8inx 3890 4 for for IN cord-010092-uftc8inx 3890 5 analysis analysis NN cord-010092-uftc8inx 3890 6 . . . cord-010092-uftc8inx 3891 1 Methods method NNS cord-010092-uftc8inx 3891 2 : : : cord-010092-uftc8inx 3891 3 Digitalization digitalization NN cord-010092-uftc8inx 3891 4 and and CC cord-010092-uftc8inx 3891 5 big big JJ cord-010092-uftc8inx 3891 6 data datum NNS cord-010092-uftc8inx 3891 7 methods method NNS cord-010092-uftc8inx 3891 8 for for IN cord-010092-uftc8inx 3891 9 processing process VBG cord-010092-uftc8inx 3891 10 various various JJ cord-010092-uftc8inx 3891 11 types type NNS cord-010092-uftc8inx 3891 12 of of IN cord-010092-uftc8inx 3891 13 data datum NNS cord-010092-uftc8inx 3891 14 : : : cord-010092-uftc8inx 3891 15 a a LS cord-010092-uftc8inx 3891 16 ) ) -RRB- cord-010092-uftc8inx 3891 17 stored store VBN cord-010092-uftc8inx 3891 18 in in IN cord-010092-uftc8inx 3891 19 paper paper NN cord-010092-uftc8inx 3891 20 form form NN cord-010092-uftc8inx 3891 21 ( ( -LRB- cord-010092-uftc8inx 3891 22 1997 1997 CD cord-010092-uftc8inx 3891 23 ) ) -RRB- cord-010092-uftc8inx 3891 24 ( ( -LRB- cord-010092-uftc8inx 3891 25 1998 1998 CD cord-010092-uftc8inx 3891 26 ) ) -RRB- cord-010092-uftc8inx 3891 27 ( ( -LRB- cord-010092-uftc8inx 3891 28 1999 1999 CD cord-010092-uftc8inx 3891 29 ) ) -RRB- cord-010092-uftc8inx 3891 30 ( ( -LRB- cord-010092-uftc8inx 3891 31 2000 2000 CD cord-010092-uftc8inx 3891 32 ) ) -RRB- cord-010092-uftc8inx 3891 33 ( ( -LRB- cord-010092-uftc8inx 3891 34 2001 2001 CD cord-010092-uftc8inx 3891 35 ) ) -RRB- cord-010092-uftc8inx 3891 36 ( ( -LRB- cord-010092-uftc8inx 3891 37 2002 2002 CD cord-010092-uftc8inx 3891 38 ) ) -RRB- cord-010092-uftc8inx 3891 39 ( ( -LRB- cord-010092-uftc8inx 3891 40 2003 2003 CD cord-010092-uftc8inx 3891 41 ) ) -RRB- cord-010092-uftc8inx 3891 42 ( ( -LRB- cord-010092-uftc8inx 3891 43 2004 2004 CD cord-010092-uftc8inx 3891 44 ) ) -RRB- cord-010092-uftc8inx 3891 45 , , , cord-010092-uftc8inx 3891 46 b b LS cord-010092-uftc8inx 3891 47 ) ) -RRB- cord-010092-uftc8inx 3891 48 digital digital NNP cord-010092-uftc8inx 3891 49 stored store VBN cord-010092-uftc8inx 3891 50 in in IN cord-010092-uftc8inx 3891 51 two two CD cord-010092-uftc8inx 3891 52 file file NN cord-010092-uftc8inx 3891 53 types type NNS cord-010092-uftc8inx 3891 54 ( ( -LRB- cord-010092-uftc8inx 3891 55 .doc .doc . cord-010092-uftc8inx 3892 1 and and CC cord-010092-uftc8inx 3892 2 .xls .xls . cord-010092-uftc8inx 3892 3 , , , cord-010092-uftc8inx 3892 4 for for IN cord-010092-uftc8inx 3892 5 the the DT cord-010092-uftc8inx 3892 6 years year NNS cord-010092-uftc8inx 3892 7 2005 2005 CD cord-010092-uftc8inx 3892 8 - - SYM cord-010092-uftc8inx 3892 9 2010 2010 CD cord-010092-uftc8inx 3892 10 and and CC cord-010092-uftc8inx 3892 11 2011 2011 CD cord-010092-uftc8inx 3892 12 - - SYM cord-010092-uftc8inx 3892 13 2017 2017 CD cord-010092-uftc8inx 3892 14 , , , cord-010092-uftc8inx 3892 15 respectively respectively RB cord-010092-uftc8inx 3892 16 ) ) -RRB- cord-010092-uftc8inx 3892 17 . . . cord-010092-uftc8inx 3893 1 For for IN cord-010092-uftc8inx 3893 2 each each DT cord-010092-uftc8inx 3893 3 data data NN cord-010092-uftc8inx 3893 4 - - HYPH cord-010092-uftc8inx 3893 5 type type NN cord-010092-uftc8inx 3893 6 , , , cord-010092-uftc8inx 3893 7 a a DT cord-010092-uftc8inx 3893 8 separate separate JJ cord-010092-uftc8inx 3893 9 Excel Excel NNP cord-010092-uftc8inx 3893 10 file file NN cord-010092-uftc8inx 3893 11 model model NN cord-010092-uftc8inx 3893 12 was be VBD cord-010092-uftc8inx 3893 13 created create VBN cord-010092-uftc8inx 3893 14 . . . cord-010092-uftc8inx 3894 1 The the DT cord-010092-uftc8inx 3894 2 models model NNS cord-010092-uftc8inx 3894 3 were be VBD cord-010092-uftc8inx 3894 4 then then RB cord-010092-uftc8inx 3894 5 merged merge VBN cord-010092-uftc8inx 3894 6 into into IN cord-010092-uftc8inx 3894 7 one one CD cord-010092-uftc8inx 3894 8 analytical analytical JJ cord-010092-uftc8inx 3894 9 table table NN cord-010092-uftc8inx 3894 10 with with IN cord-010092-uftc8inx 3894 11 data datum NNS cord-010092-uftc8inx 3894 12 processing processing NN cord-010092-uftc8inx 3894 13 methods method NNS cord-010092-uftc8inx 3894 14 . . . cord-010092-uftc8inx 3895 1 Results result NNS cord-010092-uftc8inx 3895 2 : : : cord-010092-uftc8inx 3895 3 1 1 CD cord-010092-uftc8inx 3895 4 . . . cord-010092-uftc8inx 3895 5 1344 1344 CD cord-010092-uftc8inx 3895 6 pages page NNS cord-010092-uftc8inx 3895 7 of of IN cord-010092-uftc8inx 3895 8 paper paper NN cord-010092-uftc8inx 3895 9 documents document NNS cord-010092-uftc8inx 3895 10 were be VBD cord-010092-uftc8inx 3895 11 scanned scan VBN cord-010092-uftc8inx 3895 12 . . . cord-010092-uftc8inx 3896 1 2 2 LS cord-010092-uftc8inx 3896 2 . . . cord-010092-uftc8inx 3897 1 Models model NNS cord-010092-uftc8inx 3897 2 developed develop VBD cord-010092-uftc8inx 3897 3 for for IN cord-010092-uftc8inx 3897 4 data datum NNS cord-010092-uftc8inx 3897 5 from from IN cord-010092-uftc8inx 3897 6 3 3 CD cord-010092-uftc8inx 3897 7 different different JJ cord-010092-uftc8inx 3897 8 sources source NNS cord-010092-uftc8inx 3897 9 : : : cord-010092-uftc8inx 3897 10 a. a. NNP cord-010092-uftc8inx 3897 11 Paper paper NN cord-010092-uftc8inx 3897 12 - - HYPH cord-010092-uftc8inx 3897 13 data datum NNS cord-010092-uftc8inx 3897 14 were be VBD cord-010092-uftc8inx 3897 15 rewritten rewrite VBN cord-010092-uftc8inx 3897 16 and and CC cord-010092-uftc8inx 3897 17 ascribed ascribe VBN cord-010092-uftc8inx 3897 18 to to IN cord-010092-uftc8inx 3897 19 its -PRON- PRP$ cord-010092-uftc8inx 3897 20 model model NN cord-010092-uftc8inx 3897 21 ; ; : cord-010092-uftc8inx 3897 22 outcome outcome NN cord-010092-uftc8inx 3897 23 -3 -3 NNP cord-010092-uftc8inx 3897 24 tables table NNS cord-010092-uftc8inx 3897 25 , , , cord-010092-uftc8inx 3897 26 272 272 CD cord-010092-uftc8inx 3897 27 columns column NNS cord-010092-uftc8inx 3897 28 , , , cord-010092-uftc8inx 3897 29 10,400 10,400 CD cord-010092-uftc8inx 3897 30 rows row NNS cord-010092-uftc8inx 3897 31 . . . cord-010092-uftc8inx 3898 1 b. b. NNP cord-010092-uftc8inx 3898 2 .doc .doc . cord-010092-uftc8inx 3899 1 and and CC cord-010092-uftc8inx 3899 2 .xls .xls . cord-010092-uftc8inx 3899 3 . . . cord-010092-uftc8inx 3900 1 filesdata filesdata NNP cord-010092-uftc8inx 3900 2 were be VBD cord-010092-uftc8inx 3900 3 ascribed ascribe VBN cord-010092-uftc8inx 3900 4 to to IN cord-010092-uftc8inx 3900 5 2 2 CD cord-010092-uftc8inx 3900 6 other other JJ cord-010092-uftc8inx 3900 7 models model NNS cord-010092-uftc8inx 3900 8 ; ; : cord-010092-uftc8inx 3900 9 outcome outcome VB cord-010092-uftc8inx 3900 10 -6 -6 JJ cord-010092-uftc8inx 3900 11 tables table NNS cord-010092-uftc8inx 3900 12 , , , cord-010092-uftc8inx 3900 13 1656 1656 CD cord-010092-uftc8inx 3900 14 columns column NNS cord-010092-uftc8inx 3900 15 , , , cord-010092-uftc8inx 3900 16 788 788 CD cord-010092-uftc8inx 3900 17 rows row NNS cord-010092-uftc8inx 3900 18 . . . cord-010092-uftc8inx 3901 1 3 3 LS cord-010092-uftc8inx 3901 2 . . . cord-010092-uftc8inx 3902 1 The the DT cord-010092-uftc8inx 3902 2 3 3 CD cord-010092-uftc8inx 3902 3 models model NNS cord-010092-uftc8inx 3902 4 were be VBD cord-010092-uftc8inx 3902 5 merged merge VBN cord-010092-uftc8inx 3902 6 into into IN cord-010092-uftc8inx 3902 7 1 1 CD cord-010092-uftc8inx 3902 8 analytical analytical JJ cord-010092-uftc8inx 3902 9 table table NN cord-010092-uftc8inx 3902 10 to to TO cord-010092-uftc8inx 3902 11 create create VB cord-010092-uftc8inx 3902 12 a a DT cord-010092-uftc8inx 3902 13 588 588 CD cord-010092-uftc8inx 3902 14 MB mb NN cord-010092-uftc8inx 3902 15 database database NN cord-010092-uftc8inx 3902 16 ( ( -LRB- cord-010092-uftc8inx 3902 17 comparable comparable JJ cord-010092-uftc8inx 3902 18 to to IN cord-010092-uftc8inx 3902 19 approx approx NN cord-010092-uftc8inx 3902 20 . . . cord-010092-uftc8inx 3903 1 784 784 CD cord-010092-uftc8inx 3903 2 min min NN cord-010092-uftc8inx 3903 3 of of IN cord-010092-uftc8inx 3903 4 music music NN cord-010092-uftc8inx 3903 5 ) ) -RRB- cord-010092-uftc8inx 3903 6 . . . cord-010092-uftc8inx 3904 1 4 4 LS cord-010092-uftc8inx 3904 2 . . . cord-010092-uftc8inx 3905 1 The the DT cord-010092-uftc8inx 3905 2 data datum NNS cord-010092-uftc8inx 3905 3 was be VBD cord-010092-uftc8inx 3905 4 subjected subject VBN cord-010092-uftc8inx 3905 5 to to IN cord-010092-uftc8inx 3905 6 standardization standardization NN cord-010092-uftc8inx 3905 7 , , , cord-010092-uftc8inx 3905 8 unification unification NN cord-010092-uftc8inx 3905 9 and and CC cord-010092-uftc8inx 3905 10 quality quality NN cord-010092-uftc8inx 3905 11 improvement improvement NN cord-010092-uftc8inx 3905 12 : : : cord-010092-uftc8inx 3905 13 filling fill VBG cord-010092-uftc8inx 3905 14 in in RP cord-010092-uftc8inx 3905 15 missing miss VBG cord-010092-uftc8inx 3905 16 data datum NNS cord-010092-uftc8inx 3905 17 , , , cord-010092-uftc8inx 3905 18 elimination elimination NN cord-010092-uftc8inx 3905 19 of of IN cord-010092-uftc8inx 3905 20 errors error NNS cord-010092-uftc8inx 3905 21 and and CC cord-010092-uftc8inx 3905 22 duplicate duplicate VB cord-010092-uftc8inx 3905 23 records record NNS cord-010092-uftc8inx 3905 24 that that WDT cord-010092-uftc8inx 3905 25 may may MD cord-010092-uftc8inx 3905 26 distort distort VB cord-010092-uftc8inx 3905 27 the the DT cord-010092-uftc8inx 3905 28 results result NNS cord-010092-uftc8inx 3905 29 of of IN cord-010092-uftc8inx 3905 30 analyzes analyze NNS cord-010092-uftc8inx 3905 31 . . . cord-010092-uftc8inx 3906 1 5 5 LS cord-010092-uftc8inx 3906 2 . . . cord-010092-uftc8inx 3907 1 Selection selection NN cord-010092-uftc8inx 3907 2 of of IN cord-010092-uftc8inx 3907 3 data datum NNS cord-010092-uftc8inx 3907 4 for for IN cord-010092-uftc8inx 3907 5 analysis analysis NN cord-010092-uftc8inx 3907 6 at at IN cord-010092-uftc8inx 3907 7 2 2 CD cord-010092-uftc8inx 3907 8 nd nd NNP cord-010092-uftc8inx 3907 9 stage stage NN cord-010092-uftc8inx 3907 10 . . . cord-010092-uftc8inx 3908 1 Summary Summary NNP cord-010092-uftc8inx 3908 2 / / SYM cord-010092-uftc8inx 3908 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 3908 4 : : : cord-010092-uftc8inx 3909 1 The the DT cord-010092-uftc8inx 3909 2 1 1 CD cord-010092-uftc8inx 3909 3 st st NNP cord-010092-uftc8inx 3909 4 stage stage NN cord-010092-uftc8inx 3909 5 provided provide VBD cord-010092-uftc8inx 3909 6 a a DT cord-010092-uftc8inx 3909 7 set set NN cord-010092-uftc8inx 3909 8 of of IN cord-010092-uftc8inx 3909 9 selected select VBN cord-010092-uftc8inx 3909 10 data datum NNS cord-010092-uftc8inx 3909 11 for for IN cord-010092-uftc8inx 3909 12 analysis analysis NN cord-010092-uftc8inx 3909 13 in in IN cord-010092-uftc8inx 3909 14 the the DT cord-010092-uftc8inx 3909 15 2 2 CD cord-010092-uftc8inx 3909 16 nd nd NNP cord-010092-uftc8inx 3909 17 stage stage NN cord-010092-uftc8inx 3909 18 which which WDT cord-010092-uftc8inx 3909 19 will will MD cord-010092-uftc8inx 3909 20 rely rely VB cord-010092-uftc8inx 3909 21 on on IN cord-010092-uftc8inx 3909 22 multidimensional multidimensional JJ cord-010092-uftc8inx 3909 23 statistical statistical JJ cord-010092-uftc8inx 3909 24 analysis analysis NN cord-010092-uftc8inx 3909 25 and and CC cord-010092-uftc8inx 3909 26 data data NN cord-010092-uftc8inx 3909 27 mining mining NN cord-010092-uftc8inx 3909 28 methods method NNS cord-010092-uftc8inx 3909 29 . . . cord-010092-uftc8inx 3910 1 The the DT cord-010092-uftc8inx 3910 2 outcome outcome NN cord-010092-uftc8inx 3910 3 of of IN cord-010092-uftc8inx 3910 4 such such JJ cord-010092-uftc8inx 3910 5 analysis analysis NN cord-010092-uftc8inx 3910 6 will will MD cord-010092-uftc8inx 3910 7 contribute contribute VB cord-010092-uftc8inx 3910 8 to to IN cord-010092-uftc8inx 3910 9 optimal optimal JJ cord-010092-uftc8inx 3910 10 realization realization NN cord-010092-uftc8inx 3910 11 of of IN cord-010092-uftc8inx 3910 12 objectives objective NNS cord-010092-uftc8inx 3910 13 : : : cord-010092-uftc8inx 3910 14 a a LS cord-010092-uftc8inx 3910 15 ) ) -RRB- cord-010092-uftc8inx 3910 16 gaining gain VBG cord-010092-uftc8inx 3910 17 in in IN cord-010092-uftc8inx 3910 18 - - HYPH cord-010092-uftc8inx 3910 19 depth depth NN cord-010092-uftc8inx 3910 20 knowledge knowledge NN cord-010092-uftc8inx 3910 21 about about IN cord-010092-uftc8inx 3910 22 the the DT cord-010092-uftc8inx 3910 23 fundamental fundamental JJ cord-010092-uftc8inx 3910 24 phenomena phenomena NN cord-010092-uftc8inx 3910 25 that that WDT cord-010092-uftc8inx 3910 26 shape shape NN cord-010092-uftc8inx 3910 27 Polish Polish NNP cord-010092-uftc8inx 3910 28 BTS BTS NNP cord-010092-uftc8inx 3910 29 , , , cord-010092-uftc8inx 3910 30 b b NN cord-010092-uftc8inx 3910 31 ) ) -RRB- cord-010092-uftc8inx 3910 32 identification identification NN cord-010092-uftc8inx 3910 33 of of IN cord-010092-uftc8inx 3910 34 potential potential JJ cord-010092-uftc8inx 3910 35 changes change NNS cord-010092-uftc8inx 3910 36 BCTs bct NNS cord-010092-uftc8inx 3910 37 , , , cord-010092-uftc8inx 3910 38 c c NNP cord-010092-uftc8inx 3910 39 ) ) -RRB- cord-010092-uftc8inx 3910 40 development development NN cord-010092-uftc8inx 3910 41 of of IN cord-010092-uftc8inx 3910 42 overall overall JJ cord-010092-uftc8inx 3910 43 guidelines guideline NNS cord-010092-uftc8inx 3910 44 for for IN cord-010092-uftc8inx 3910 45 change change NN cord-010092-uftc8inx 3910 46 management management NN cord-010092-uftc8inx 3910 47 . . . cord-010092-uftc8inx 3911 1 aimed aim VBN cord-010092-uftc8inx 3911 2 to to TO cord-010092-uftc8inx 3911 3 touch touch VB cord-010092-uftc8inx 3911 4 untouched untouched JJ cord-010092-uftc8inx 3911 5 or or CC cord-010092-uftc8inx 3911 6 less less RBR cord-010092-uftc8inx 3911 7 touched touch VBN cord-010092-uftc8inx 3911 8 topics topic NNS cord-010092-uftc8inx 3911 9 of of IN cord-010092-uftc8inx 3911 10 BB&TM BB&TM NNP cord-010092-uftc8inx 3911 11 . . . cord-010092-uftc8inx 3912 1 So so RB cord-010092-uftc8inx 3912 2 far far RB cord-010092-uftc8inx 3912 3 8 8 CD cord-010092-uftc8inx 3912 4 workshops workshop NNS cord-010092-uftc8inx 3912 5 were be VBD cord-010092-uftc8inx 3912 6 organized organize VBN cord-010092-uftc8inx 3912 7 and and CC cord-010092-uftc8inx 3912 8 each each DT cord-010092-uftc8inx 3912 9 year year NN cord-010092-uftc8inx 3912 10 around around IN cord-010092-uftc8inx 3912 11 30 30 CD cord-010092-uftc8inx 3912 12 countries country NNS cord-010092-uftc8inx 3912 13 were be VBD cord-010092-uftc8inx 3912 14 participated participate VBN cord-010092-uftc8inx 3912 15 from from IN cord-010092-uftc8inx 3912 16 almost almost RB cord-010092-uftc8inx 3912 17 all all DT cord-010092-uftc8inx 3912 18 religious religious JJ cord-010092-uftc8inx 3912 19 , , , cord-010092-uftc8inx 3912 20 ethnical ethnical JJ cord-010092-uftc8inx 3912 21 , , , cord-010092-uftc8inx 3912 22 social social JJ cord-010092-uftc8inx 3912 23 , , , cord-010092-uftc8inx 3912 24 cultural cultural JJ cord-010092-uftc8inx 3912 25 and and CC cord-010092-uftc8inx 3912 26 economic economic JJ cord-010092-uftc8inx 3912 27 situations situation NNS cord-010092-uftc8inx 3912 28 of of IN cord-010092-uftc8inx 3912 29 the the DT cord-010092-uftc8inx 3912 30 world world NN cord-010092-uftc8inx 3912 31 . . . cord-010092-uftc8inx 3913 1 6 6 LS cord-010092-uftc8inx 3913 2 . . . cord-010092-uftc8inx 3914 1 Supported support VBN cord-010092-uftc8inx 3914 2 realization realization NN cord-010092-uftc8inx 3914 3 of of IN cord-010092-uftc8inx 3914 4 major major JJ cord-010092-uftc8inx 3914 5 changes change NNS cord-010092-uftc8inx 3914 6 in in IN cord-010092-uftc8inx 3914 7 BB&TM BB&TM NNP cord-010092-uftc8inx 3914 8 in in IN cord-010092-uftc8inx 3914 9 Turkey Turkey NNP cord-010092-uftc8inx 3914 10 ; ; : cord-010092-uftc8inx 3914 11 a a DT cord-010092-uftc8inx 3914 12 convincing convincing JJ cord-010092-uftc8inx 3914 13 medical medical JJ cord-010092-uftc8inx 3914 14 individuals individual NNS cord-010092-uftc8inx 3914 15 and and CC cord-010092-uftc8inx 3914 16 agencies agency NNS cord-010092-uftc8inx 3914 17 mainly mainly RB cord-010092-uftc8inx 3914 18 MoH MoH NNP cord-010092-uftc8inx 3914 19 to to TO cord-010092-uftc8inx 3914 20 give give VB cord-010092-uftc8inx 3914 21 the the DT cord-010092-uftc8inx 3914 22 deserved deserved JJ cord-010092-uftc8inx 3914 23 consideration consideration NN cord-010092-uftc8inx 3914 24 to to IN cord-010092-uftc8inx 3914 25 BB&TM BB&TM NNP cord-010092-uftc8inx 3914 26 b b LS cord-010092-uftc8inx 3914 27 encouraging encourage VBG cord-010092-uftc8inx 3914 28 the the DT cord-010092-uftc8inx 3914 29 recognition recognition NN cord-010092-uftc8inx 3914 30 and and CC cord-010092-uftc8inx 3914 31 establishment establishment NN cord-010092-uftc8inx 3914 32 of of IN cord-010092-uftc8inx 3914 33 national national JJ cord-010092-uftc8inx 3914 34 blood blood NN cord-010092-uftc8inx 3914 35 program program NN cord-010092-uftc8inx 3914 36 c c LS cord-010092-uftc8inx 3914 37 issuing issue VBG cord-010092-uftc8inx 3914 38 a a DT cord-010092-uftc8inx 3914 39 new new JJ cord-010092-uftc8inx 3914 40 blood blood NN cord-010092-uftc8inx 3914 41 act act NN cord-010092-uftc8inx 3914 42 and and CC cord-010092-uftc8inx 3914 43 numerous numerous JJ cord-010092-uftc8inx 3914 44 necessary necessary JJ cord-010092-uftc8inx 3914 45 bylaws bylaw NNS cord-010092-uftc8inx 3914 46 , , , cord-010092-uftc8inx 3914 47 etc etc FW cord-010092-uftc8inx 3914 48 . . . cord-010092-uftc8inx 3915 1 d d LS cord-010092-uftc8inx 3915 2 creating create VBG cord-010092-uftc8inx 3915 3 an an DT cord-010092-uftc8inx 3915 4 appropriate appropriate JJ cord-010092-uftc8inx 3915 5 standard standard JJ cord-010092-uftc8inx 3915 6 donor donor NN cord-010092-uftc8inx 3915 7 questionnaire questionnaire NN cord-010092-uftc8inx 3915 8 form form NN cord-010092-uftc8inx 3915 9 e e LS cord-010092-uftc8inx 3915 10 changing change VBG cord-010092-uftc8inx 3915 11 blood blood NN cord-010092-uftc8inx 3915 12 transfusion transfusion NN cord-010092-uftc8inx 3915 13 practice practice NN cord-010092-uftc8inx 3915 14 from from IN cord-010092-uftc8inx 3915 15 % % NN cord-010092-uftc8inx 3915 16 96 96 CD cord-010092-uftc8inx 3915 17 whole whole JJ cord-010092-uftc8inx 3915 18 blood blood NN cord-010092-uftc8inx 3915 19 ( ( -LRB- cord-010092-uftc8inx 3915 20 at at IN cord-010092-uftc8inx 3915 21 1996 1996 CD cord-010092-uftc8inx 3915 22 ) ) -RRB- cord-010092-uftc8inx 3915 23 to to IN cord-010092-uftc8inx 3915 24 5 5 CD cord-010092-uftc8inx 3915 25 % % NN cord-010092-uftc8inx 3915 26 . . . cord-010092-uftc8inx 3916 1 f f LS cord-010092-uftc8inx 3916 2 changing change VBG cord-010092-uftc8inx 3916 3 donated donate VBN cord-010092-uftc8inx 3916 4 blood blood NN cord-010092-uftc8inx 3916 5 screening screening NN cord-010092-uftc8inx 3916 6 criteria criterion NNS cord-010092-uftc8inx 3916 7 ; ; : cord-010092-uftc8inx 3916 8 while while IN cord-010092-uftc8inx 3916 9 anti anti JJ cord-010092-uftc8inx 3916 10 - - JJ cord-010092-uftc8inx 3916 11 HCV HCV NNP cord-010092-uftc8inx 3916 12 screening screening NN cord-010092-uftc8inx 3916 13 became become VBD cord-010092-uftc8inx 3916 14 obligatory obligatory JJ cord-010092-uftc8inx 3916 15 Malaria Malaria NNP cord-010092-uftc8inx 3916 16 , , , cord-010092-uftc8inx 3916 17 screening screening NN cord-010092-uftc8inx 3916 18 cancelled cancel VBD cord-010092-uftc8inx 3916 19 g g NNP cord-010092-uftc8inx 3916 20 preparing prepare VBG cord-010092-uftc8inx 3916 21 national national NNP cord-010092-uftc8inx 3916 22 guidelines guideline NNS cord-010092-uftc8inx 3916 23 h h NNP cord-010092-uftc8inx 3916 24 promoting promote VBG cord-010092-uftc8inx 3916 25 Haemovigilance Haemovigilance NNP cord-010092-uftc8inx 3916 26 nurse nurse NN cord-010092-uftc8inx 3916 27 post post NN cord-010092-uftc8inx 3917 1 i i PRP cord-010092-uftc8inx 3917 2 promoting promote VBG cord-010092-uftc8inx 3917 3 Patient Patient NNP cord-010092-uftc8inx 3917 4 Blood Blood NNP cord-010092-uftc8inx 3917 5 Management Management NNP cord-010092-uftc8inx 3917 6 7 7 CD cord-010092-uftc8inx 3917 7 . . . cord-010092-uftc8inx 3918 1 Around around IN cord-010092-uftc8inx 3918 2 11,000 11,000 CD cord-010092-uftc8inx 3918 3 blood blood NN cord-010092-uftc8inx 3918 4 bankers banker NNS cord-010092-uftc8inx 3918 5 attended attend VBD cord-010092-uftc8inx 3918 6 national national JJ cord-010092-uftc8inx 3918 7 courses course NNS cord-010092-uftc8inx 3918 8 , , , cord-010092-uftc8inx 3918 9 7,000 7,000 CD cord-010092-uftc8inx 3918 10 attended attend VBD cord-010092-uftc8inx 3918 11 national national JJ cord-010092-uftc8inx 3918 12 congresses congress NNS cord-010092-uftc8inx 3918 13 , , , cord-010092-uftc8inx 3918 14 18,000 18,000 CD cord-010092-uftc8inx 3918 15 attended attend VBD cord-010092-uftc8inx 3918 16 nationwide nationwide JJ cord-010092-uftc8inx 3918 17 symposiums symposium NNS cord-010092-uftc8inx 3918 18 . . . cord-010092-uftc8inx 3919 1 Summary Summary NNP cord-010092-uftc8inx 3919 2 / / SYM cord-010092-uftc8inx 3919 3 Conclusions conclusion NNS cord-010092-uftc8inx 3919 4 : : : cord-010092-uftc8inx 3919 5 BBTST BBTST NNP cord-010092-uftc8inx 3919 6 can can MD cord-010092-uftc8inx 3919 7 be be VB cord-010092-uftc8inx 3919 8 accepted accept VBN cord-010092-uftc8inx 3919 9 as as IN cord-010092-uftc8inx 3919 10 a a DT cord-010092-uftc8inx 3919 11 sample sample NN cord-010092-uftc8inx 3919 12 how how WRB cord-010092-uftc8inx 3919 13 a a DT cord-010092-uftc8inx 3919 14 scientific scientific JJ cord-010092-uftc8inx 3919 15 nongovernmental nongovernmental JJ cord-010092-uftc8inx 3919 16 organization organization NN cord-010092-uftc8inx 3919 17 may may MD cord-010092-uftc8inx 3919 18 give give VB cord-010092-uftc8inx 3919 19 a a DT cord-010092-uftc8inx 3919 20 very very RB cord-010092-uftc8inx 3919 21 positive positive JJ cord-010092-uftc8inx 3919 22 impact impact NN cord-010092-uftc8inx 3919 23 on on IN cord-010092-uftc8inx 3919 24 developing develop VBG cord-010092-uftc8inx 3919 25 and and CC cord-010092-uftc8inx 3919 26 progressing progress VBG cord-010092-uftc8inx 3919 27 BB&TM bb&tm NN cord-010092-uftc8inx 3919 28 activities activity NNS cord-010092-uftc8inx 3919 29 with with IN cord-010092-uftc8inx 3919 30 close close JJ cord-010092-uftc8inx 3919 31 collaboration collaboration NN cord-010092-uftc8inx 3919 32 MoH moh NN cord-010092-uftc8inx 3919 33 and and CC cord-010092-uftc8inx 3919 34 other other JJ cord-010092-uftc8inx 3919 35 related related JJ cord-010092-uftc8inx 3919 36 organizations organization NNS cord-010092-uftc8inx 3919 37 Abstract Abstract NNP cord-010092-uftc8inx 3919 38 withdrawn withdraw VBN cord-010092-uftc8inx 3919 39 . . . cord-010092-uftc8inx 3920 1 Background background NN cord-010092-uftc8inx 3920 2 : : : cord-010092-uftc8inx 3921 1 Globally globally RB cord-010092-uftc8inx 3921 2 there there EX cord-010092-uftc8inx 3921 3 is be VBZ cord-010092-uftc8inx 3921 4 growing grow VBG cord-010092-uftc8inx 3921 5 investment investment NN cord-010092-uftc8inx 3921 6 in in IN cord-010092-uftc8inx 3921 7 information information NN cord-010092-uftc8inx 3921 8 technology technology NN cord-010092-uftc8inx 3921 9 ( ( -LRB- cord-010092-uftc8inx 3921 10 IT it NN cord-010092-uftc8inx 3921 11 ) ) -RRB- cord-010092-uftc8inx 3921 12 in in IN cord-010092-uftc8inx 3921 13 business business NN cord-010092-uftc8inx 3921 14 . . . cord-010092-uftc8inx 3922 1 This this DT cord-010092-uftc8inx 3922 2 similar similar JJ cord-010092-uftc8inx 3922 3 trend trend NN cord-010092-uftc8inx 3922 4 has have VBZ cord-010092-uftc8inx 3922 5 been be VBN cord-010092-uftc8inx 3922 6 observed observe VBN cord-010092-uftc8inx 3922 7 in in IN cord-010092-uftc8inx 3922 8 blood blood NN cord-010092-uftc8inx 3922 9 establishment establishment NN cord-010092-uftc8inx 3922 10 computerized computerized NN cord-010092-uftc8inx 3922 11 systems system NNS cord-010092-uftc8inx 3922 12 ( ( -LRB- cord-010092-uftc8inx 3922 13 BECS BECS NNP cord-010092-uftc8inx 3922 14 ) ) -RRB- cord-010092-uftc8inx 3922 15 . . . cord-010092-uftc8inx 3923 1 The the DT cord-010092-uftc8inx 3923 2 IT IT NNP cord-010092-uftc8inx 3923 3 investment investment NN cord-010092-uftc8inx 3923 4 can can MD cord-010092-uftc8inx 3923 5 be be VB cord-010092-uftc8inx 3923 6 high high JJ cord-010092-uftc8inx 3923 7 hence hence RB cord-010092-uftc8inx 3923 8 IT it NN cord-010092-uftc8inx 3923 9 decisions decision NNS cord-010092-uftc8inx 3923 10 need need VBP cord-010092-uftc8inx 3923 11 to to TO cord-010092-uftc8inx 3923 12 be be VB cord-010092-uftc8inx 3923 13 properly properly RB cord-010092-uftc8inx 3923 14 informed inform VBN cord-010092-uftc8inx 3923 15 . . . cord-010092-uftc8inx 3924 1 The the DT cord-010092-uftc8inx 3924 2 Africa Africa NNP cord-010092-uftc8inx 3924 3 Society Society NNP cord-010092-uftc8inx 3924 4 for for IN cord-010092-uftc8inx 3924 5 Blood Blood NNP cord-010092-uftc8inx 3924 6 Transfusion Transfusion NNP cord-010092-uftc8inx 3925 1 ( ( -LRB- cord-010092-uftc8inx 3925 2 AfSBT AfSBT NNP cord-010092-uftc8inx 3925 3 ) ) -RRB- cord-010092-uftc8inx 3925 4 encourages encourage VBZ cord-010092-uftc8inx 3925 5 the the DT cord-010092-uftc8inx 3925 6 use use NN cord-010092-uftc8inx 3925 7 of of IN cord-010092-uftc8inx 3925 8 ITs its PRP$ cord-010092-uftc8inx 3925 9 in in IN cord-010092-uftc8inx 3925 10 African african JJ cord-010092-uftc8inx 3925 11 blood blood NN cord-010092-uftc8inx 3925 12 services service NNS cord-010092-uftc8inx 3925 13 as as IN cord-010092-uftc8inx 3925 14 this this DT cord-010092-uftc8inx 3925 15 optimize optimize VBP cord-010092-uftc8inx 3925 16 quality quality NN cord-010092-uftc8inx 3925 17 blood blood NN cord-010092-uftc8inx 3925 18 services service NNS cord-010092-uftc8inx 3925 19 , , , cord-010092-uftc8inx 3925 20 thereby thereby RB cord-010092-uftc8inx 3925 21 improving improve VBG cord-010092-uftc8inx 3925 22 patient patient NN cord-010092-uftc8inx 3925 23 's 's POS cord-010092-uftc8inx 3925 24 outcomes outcome NNS cord-010092-uftc8inx 3925 25 . . . cord-010092-uftc8inx 3926 1 AfSBT afsbt DT cord-010092-uftc8inx 3926 2 established establish VBN cord-010092-uftc8inx 3926 3 in in IN cord-010092-uftc8inx 3926 4 2016 2016 CD cord-010092-uftc8inx 3926 5 an an DT cord-010092-uftc8inx 3926 6 IT IT NNP cord-010092-uftc8inx 3926 7 working work VBG cord-010092-uftc8inx 3926 8 group group NN cord-010092-uftc8inx 3926 9 ( ( -LRB- cord-010092-uftc8inx 3926 10 AfSBT AfSBT NNP cord-010092-uftc8inx 3926 11 ITWG ITWG NNP cord-010092-uftc8inx 3926 12 ) ) -RRB- cord-010092-uftc8inx 3926 13 with with IN cord-010092-uftc8inx 3926 14 the the DT cord-010092-uftc8inx 3926 15 support support NN cord-010092-uftc8inx 3926 16 of of IN cord-010092-uftc8inx 3926 17 the the DT cord-010092-uftc8inx 3926 18 Swiss Swiss NNP cord-010092-uftc8inx 3926 19 Red Red NNP cord-010092-uftc8inx 3926 20 Cross Cross NNP cord-010092-uftc8inx 3926 21 ( ( -LRB- cord-010092-uftc8inx 3926 22 SRC SRC NNP cord-010092-uftc8inx 3926 23 ) ) -RRB- cord-010092-uftc8inx 3926 24 to to TO cord-010092-uftc8inx 3926 25 spearhead spearhead VB cord-010092-uftc8inx 3926 26 the the DT cord-010092-uftc8inx 3926 27 IT IT NNP cord-010092-uftc8inx 3926 28 standards standard NNS cord-010092-uftc8inx 3926 29 among among IN cord-010092-uftc8inx 3926 30 member member NN cord-010092-uftc8inx 3926 31 blood blood NN cord-010092-uftc8inx 3926 32 services service NNS cord-010092-uftc8inx 3926 33 . . . cord-010092-uftc8inx 3927 1 A a DT cord-010092-uftc8inx 3927 2 number number NN cord-010092-uftc8inx 3927 3 of of IN cord-010092-uftc8inx 3927 4 priority priority NN cord-010092-uftc8inx 3927 5 IT it NN cord-010092-uftc8inx 3927 6 thematic thematic JJ cord-010092-uftc8inx 3927 7 areas area NNS cord-010092-uftc8inx 3927 8 were be VBD cord-010092-uftc8inx 3927 9 identified identify VBN cord-010092-uftc8inx 3927 10 . . . cord-010092-uftc8inx 3928 1 These these DT cord-010092-uftc8inx 3928 2 includes include VBZ cord-010092-uftc8inx 3928 3 IT it NN cord-010092-uftc8inx 3928 4 governance governance NN cord-010092-uftc8inx 3928 5 which which WDT cord-010092-uftc8inx 3928 6 focuses focus VBZ cord-010092-uftc8inx 3928 7 on on IN cord-010092-uftc8inx 3928 8 creation creation NN cord-010092-uftc8inx 3928 9 ( ( -LRB- cord-010092-uftc8inx 3928 10 strategic strategic JJ cord-010092-uftc8inx 3928 11 alignment alignment NN cord-010092-uftc8inx 3928 12 ) ) -RRB- cord-010092-uftc8inx 3928 13 and and CC cord-010092-uftc8inx 3928 14 preservation preservation NN cord-010092-uftc8inx 3928 15 ( ( -LRB- cord-010092-uftc8inx 3928 16 risk risk NN cord-010092-uftc8inx 3928 17 management management NN cord-010092-uftc8inx 3928 18 ) ) -RRB- cord-010092-uftc8inx 3928 19 of of IN cord-010092-uftc8inx 3928 20 business business NN cord-010092-uftc8inx 3928 21 value value NN cord-010092-uftc8inx 3928 22 . . . cord-010092-uftc8inx 3929 1 There there EX cord-010092-uftc8inx 3929 2 is be VBZ cord-010092-uftc8inx 3929 3 absence absence NN cord-010092-uftc8inx 3929 4 of of IN cord-010092-uftc8inx 3929 5 published publish VBN cord-010092-uftc8inx 3929 6 literature literature NN cord-010092-uftc8inx 3929 7 on on IN cord-010092-uftc8inx 3929 8 how how WRB cord-010092-uftc8inx 3929 9 a a DT cord-010092-uftc8inx 3929 10 structured structured JJ cord-010092-uftc8inx 3929 11 IT it NN cord-010092-uftc8inx 3929 12 governance governance NN cord-010092-uftc8inx 3929 13 framework framework NN cord-010092-uftc8inx 3929 14 can can MD cord-010092-uftc8inx 3929 15 be be VB cord-010092-uftc8inx 3929 16 implemented implement VBN cord-010092-uftc8inx 3929 17 in in IN cord-010092-uftc8inx 3929 18 a a DT cord-010092-uftc8inx 3929 19 resource resource NN cord-010092-uftc8inx 3929 20 constrained constrain VBN cord-010092-uftc8inx 3929 21 setting setting NN cord-010092-uftc8inx 3929 22 . . . cord-010092-uftc8inx 3930 1 A a DT cord-010092-uftc8inx 3930 2 review review NN cord-010092-uftc8inx 3930 3 of of IN cord-010092-uftc8inx 3930 4 the the DT cord-010092-uftc8inx 3930 5 National National NNP cord-010092-uftc8inx 3930 6 Blood Blood NNP cord-010092-uftc8inx 3930 7 Service Service NNP cord-010092-uftc8inx 3930 8 Zimbabwe Zimbabwe NNP cord-010092-uftc8inx 3930 9 ( ( -LRB- cord-010092-uftc8inx 3930 10 NBSZ NBSZ NNP cord-010092-uftc8inx 3930 11 ) ) -RRB- cord-010092-uftc8inx 3931 1 IT it NN cord-010092-uftc8inx 3931 2 governance governance NN cord-010092-uftc8inx 3931 3 was be VBD cord-010092-uftc8inx 3931 4 done do VBN cord-010092-uftc8inx 3931 5 based base VBN cord-010092-uftc8inx 3931 6 on on IN cord-010092-uftc8inx 3931 7 published publish VBN cord-010092-uftc8inx 3931 8 IT IT NNP cord-010092-uftc8inx 3931 9 governance governance NN cord-010092-uftc8inx 3931 10 framework framework NN cord-010092-uftc8inx 3931 11 . . . cord-010092-uftc8inx 3932 1 Aims aim VBZ cord-010092-uftc8inx 3932 2 : : : cord-010092-uftc8inx 3933 1 To to TO cord-010092-uftc8inx 3933 2 explore explore VB cord-010092-uftc8inx 3933 3 how how WRB cord-010092-uftc8inx 3933 4 a a DT cord-010092-uftc8inx 3933 5 structured structured JJ cord-010092-uftc8inx 3933 6 IT it NN cord-010092-uftc8inx 3933 7 governance governance NN cord-010092-uftc8inx 3933 8 can can MD cord-010092-uftc8inx 3933 9 be be VB cord-010092-uftc8inx 3933 10 developed develop VBN cord-010092-uftc8inx 3933 11 , , , cord-010092-uftc8inx 3933 12 implemented implement VBN cord-010092-uftc8inx 3933 13 and and CC cord-010092-uftc8inx 3933 14 monitored monitor VBN cord-010092-uftc8inx 3933 15 in in IN cord-010092-uftc8inx 3933 16 a a DT cord-010092-uftc8inx 3933 17 resource resource NN cord-010092-uftc8inx 3933 18 constrained constrain VBN cord-010092-uftc8inx 3933 19 setting setting NN cord-010092-uftc8inx 3933 20 . . . cord-010092-uftc8inx 3934 1 Methods method NNS cord-010092-uftc8inx 3934 2 : : : cord-010092-uftc8inx 3935 1 A a DT cord-010092-uftc8inx 3935 2 published publish VBN cord-010092-uftc8inx 3935 3 MIT MIT NNP cord-010092-uftc8inx 3935 4 - - HYPH cord-010092-uftc8inx 3935 5 CISR CISR NNP cord-010092-uftc8inx 3935 6 framework framework NN cord-010092-uftc8inx 3935 7 which which WDT cord-010092-uftc8inx 3935 8 has have VBZ cord-010092-uftc8inx 3935 9 six six CD cord-010092-uftc8inx 3935 10 components component NNS cord-010092-uftc8inx 3935 11 was be VBD cord-010092-uftc8inx 3935 12 used use VBN cord-010092-uftc8inx 3935 13 to to TO cord-010092-uftc8inx 3935 14 assess assess VB cord-010092-uftc8inx 3935 15 the the DT cord-010092-uftc8inx 3935 16 strength strength NN cord-010092-uftc8inx 3935 17 , , , cord-010092-uftc8inx 3935 18 gaps gap NNS cord-010092-uftc8inx 3935 19 and and CC cord-010092-uftc8inx 3935 20 opportunities opportunity NNS cord-010092-uftc8inx 3935 21 of of IN cord-010092-uftc8inx 3935 22 the the DT cord-010092-uftc8inx 3935 23 IT IT NNP cord-010092-uftc8inx 3935 24 governance governance NN cord-010092-uftc8inx 3935 25 . . . cord-010092-uftc8inx 3936 1 Results result NNS cord-010092-uftc8inx 3936 2 : : : cord-010092-uftc8inx 3936 3 NBSZ NBSZ NNP cord-010092-uftc8inx 3936 4 has have VBZ cord-010092-uftc8inx 3936 5 been be VBN cord-010092-uftc8inx 3936 6 implementing implement VBG cord-010092-uftc8inx 3936 7 an an DT cord-010092-uftc8inx 3936 8 evolving evolve VBG cord-010092-uftc8inx 3936 9 structured structure VBN cord-010092-uftc8inx 3936 10 IT it NN cord-010092-uftc8inx 3936 11 governance governance NN cord-010092-uftc8inx 3936 12 system system NN cord-010092-uftc8inx 3936 13 . . . cord-010092-uftc8inx 3937 1 In in IN cord-010092-uftc8inx 3937 2 terms term NNS cord-010092-uftc8inx 3937 3 of of IN cord-010092-uftc8inx 3937 4 Service service NN cord-010092-uftc8inx 3937 5 strategy strategy NN cord-010092-uftc8inx 3937 6 and and CC cord-010092-uftc8inx 3937 7 organization organization NN cord-010092-uftc8inx 3937 8 there there EX cord-010092-uftc8inx 3937 9 is be VBZ cord-010092-uftc8inx 3937 10 a a DT cord-010092-uftc8inx 3937 11 well well RB cord-010092-uftc8inx 3937 12 - - HYPH cord-010092-uftc8inx 3937 13 established establish VBN cord-010092-uftc8inx 3937 14 IT it PRP cord-010092-uftc8inx 3937 15 function function NN cord-010092-uftc8inx 3937 16 which which WDT cord-010092-uftc8inx 3937 17 is be VBZ cord-010092-uftc8inx 3937 18 reflected reflect VBN cord-010092-uftc8inx 3937 19 in in IN cord-010092-uftc8inx 3937 20 the the DT cord-010092-uftc8inx 3937 21 NBSZ NBSZ NNP cord-010092-uftc8inx 3937 22 strategic strategic JJ cord-010092-uftc8inx 3937 23 plans plan NNS cord-010092-uftc8inx 3937 24 . . . cord-010092-uftc8inx 3938 1 This this DT cord-010092-uftc8inx 3938 2 ensures ensure VBZ cord-010092-uftc8inx 3938 3 IT it PRP cord-010092-uftc8inx 3938 4 annual annual JJ cord-010092-uftc8inx 3938 5 budgetary budgetary JJ cord-010092-uftc8inx 3938 6 support support NN cord-010092-uftc8inx 3938 7 , , , cord-010092-uftc8inx 3938 8 which which WDT cord-010092-uftc8inx 3938 9 averages average VBZ cord-010092-uftc8inx 3938 10 4.3 4.3 CD cord-010092-uftc8inx 3938 11 % % NN cord-010092-uftc8inx 3938 12 of of IN cord-010092-uftc8inx 3938 13 the the DT cord-010092-uftc8inx 3938 14 total total JJ cord-010092-uftc8inx 3938 15 budget budget NN cord-010092-uftc8inx 3938 16 . . . cord-010092-uftc8inx 3939 1 The the DT cord-010092-uftc8inx 3939 2 IT IT NNP cord-010092-uftc8inx 3939 3 governance governance NN cord-010092-uftc8inx 3939 4 arrangements arrangement NNS cord-010092-uftc8inx 3939 5 are be VBP cord-010092-uftc8inx 3939 6 such such JJ cord-010092-uftc8inx 3939 7 that that DT cord-010092-uftc8inx 3939 8 decision decision NN cord-010092-uftc8inx 3939 9 rights right NNS cord-010092-uftc8inx 3939 10 are be VBP cord-010092-uftc8inx 3939 11 assigned assign VBN cord-010092-uftc8inx 3939 12 to to IN cord-010092-uftc8inx 3939 13 different different JJ cord-010092-uftc8inx 3939 14 IT IT NNP cord-010092-uftc8inx 3939 15 staff staff NN cord-010092-uftc8inx 3939 16 ( ( -LRB- cord-010092-uftc8inx 3939 17 executives executive NNS cord-010092-uftc8inx 3939 18 , , , cord-010092-uftc8inx 3939 19 IT it PRP cord-010092-uftc8inx 3939 20 specialist specialist NN cord-010092-uftc8inx 3939 21 , , , cord-010092-uftc8inx 3939 22 and and CC cord-010092-uftc8inx 3939 23 users user NNS cord-010092-uftc8inx 3939 24 ) ) -RRB- cord-010092-uftc8inx 3939 25 . . . cord-010092-uftc8inx 3940 1 A a DT cord-010092-uftc8inx 3940 2 range range NN cord-010092-uftc8inx 3940 3 of of IN cord-010092-uftc8inx 3940 4 IT it NN cord-010092-uftc8inx 3940 5 solutions solution NNS cord-010092-uftc8inx 3940 6 have have VBP cord-010092-uftc8inx 3940 7 been be VBN cord-010092-uftc8inx 3940 8 embedded embed VBN cord-010092-uftc8inx 3940 9 within within IN cord-010092-uftc8inx 3940 10 the the DT cord-010092-uftc8inx 3940 11 NBSZ NBSZ NNP cord-010092-uftc8inx 3940 12 operations operation NNS cord-010092-uftc8inx 3940 13 such such JJ cord-010092-uftc8inx 3940 14 as as IN cord-010092-uftc8inx 3940 15 BECS BECS NNP cord-010092-uftc8inx 3940 16 , , , cord-010092-uftc8inx 3940 17 financial financial JJ cord-010092-uftc8inx 3940 18 , , , cord-010092-uftc8inx 3940 19 donor donor NN cord-010092-uftc8inx 3940 20 mobile mobile NN cord-010092-uftc8inx 3940 21 application application NN cord-010092-uftc8inx 3940 22 , , , cord-010092-uftc8inx 3940 23 social social JJ cord-010092-uftc8inx 3940 24 media medium NNS cord-010092-uftc8inx 3940 25 , , , cord-010092-uftc8inx 3940 26 temperature temperature NN cord-010092-uftc8inx 3940 27 monitoring monitoring NN cord-010092-uftc8inx 3940 28 , , , cord-010092-uftc8inx 3940 29 and and CC cord-010092-uftc8inx 3940 30 human human JJ cord-010092-uftc8inx 3940 31 resources resource NNS cord-010092-uftc8inx 3940 32 . . . cord-010092-uftc8inx 3941 1 The the DT cord-010092-uftc8inx 3941 2 business business NN cord-010092-uftc8inx 3941 3 performance performance NN cord-010092-uftc8inx 3941 4 goals goal NNS cord-010092-uftc8inx 3941 5 are be VBP cord-010092-uftc8inx 3941 6 defined define VBN cord-010092-uftc8inx 3941 7 and and CC cord-010092-uftc8inx 3941 8 are be VBP cord-010092-uftc8inx 3941 9 congruent congruent JJ cord-010092-uftc8inx 3941 10 across across IN cord-010092-uftc8inx 3941 11 the the DT cord-010092-uftc8inx 3941 12 various various JJ cord-010092-uftc8inx 3941 13 business business NN cord-010092-uftc8inx 3941 14 units unit NNS cord-010092-uftc8inx 3941 15 . . . cord-010092-uftc8inx 3942 1 IT it NN cord-010092-uftc8inx 3942 2 organization organization NN cord-010092-uftc8inx 3942 3 and and CC cord-010092-uftc8inx 3942 4 desirable desirable JJ cord-010092-uftc8inx 3942 5 behaviors behavior NNS cord-010092-uftc8inx 3942 6 are be VBP cord-010092-uftc8inx 3942 7 documented document VBN cord-010092-uftc8inx 3942 8 in in IN cord-010092-uftc8inx 3942 9 the the DT cord-010092-uftc8inx 3942 10 ICT ICT NNP cord-010092-uftc8inx 3942 11 policies policy NNS cord-010092-uftc8inx 3942 12 and and CC cord-010092-uftc8inx 3942 13 procedures procedure NNS cord-010092-uftc8inx 3942 14 and and CC cord-010092-uftc8inx 3942 15 were be VBD cord-010092-uftc8inx 3942 16 needed need VBN cord-010092-uftc8inx 3942 17 remedial remedial JJ cord-010092-uftc8inx 3942 18 actions action NNS cord-010092-uftc8inx 3942 19 are be VBP cord-010092-uftc8inx 3942 20 available available JJ cord-010092-uftc8inx 3942 21 through through IN cord-010092-uftc8inx 3942 22 the the DT cord-010092-uftc8inx 3942 23 code code NN cord-010092-uftc8inx 3942 24 of of IN cord-010092-uftc8inx 3942 25 conduct conduct NN cord-010092-uftc8inx 3942 26 . . . cord-010092-uftc8inx 3943 1 The the DT cord-010092-uftc8inx 3943 2 IT IT NNP cord-010092-uftc8inx 3943 3 metrics metric NNS cord-010092-uftc8inx 3943 4 are be VBP cord-010092-uftc8inx 3943 5 included include VBN cord-010092-uftc8inx 3943 6 within within IN cord-010092-uftc8inx 3943 7 the the DT cord-010092-uftc8inx 3943 8 NBSZ NBSZ NNP cord-010092-uftc8inx 3943 9 monitoring monitoring NN cord-010092-uftc8inx 3943 10 and and CC cord-010092-uftc8inx 3943 11 evaluation evaluation NN cord-010092-uftc8inx 3943 12 system system NN cord-010092-uftc8inx 3943 13 which which WDT cord-010092-uftc8inx 3943 14 use use VBP cord-010092-uftc8inx 3943 15 a a DT cord-010092-uftc8inx 3943 16 four four CD cord-010092-uftc8inx 3943 17 colored colored JJ cord-010092-uftc8inx 3943 18 traffic traffic NN cord-010092-uftc8inx 3943 19 lighting lighting NN cord-010092-uftc8inx 3943 20 reporting report VBG cord-010092-uftc8inx 3943 21 system system NN cord-010092-uftc8inx 3943 22 . . . cord-010092-uftc8inx 3944 1 It -PRON- PRP cord-010092-uftc8inx 3944 2 was be VBD cord-010092-uftc8inx 3944 3 noted note VBN cord-010092-uftc8inx 3944 4 that that IN cord-010092-uftc8inx 3944 5 the the DT cord-010092-uftc8inx 3944 6 IT IT NNP cord-010092-uftc8inx 3944 7 accountabilities accountability NNS cord-010092-uftc8inx 3944 8 are be VBP cord-010092-uftc8inx 3944 9 undesirably undesirably RB cord-010092-uftc8inx 3944 10 tilted tilt VBN cord-010092-uftc8inx 3944 11 to to IN cord-010092-uftc8inx 3944 12 the the DT cord-010092-uftc8inx 3944 13 IT IT NNP cord-010092-uftc8inx 3944 14 specialist specialist NN cord-010092-uftc8inx 3944 15 only only RB cord-010092-uftc8inx 3944 16 hence hence RB cord-010092-uftc8inx 3944 17 some some DT cord-010092-uftc8inx 3944 18 ICT ict NN cord-010092-uftc8inx 3944 19 projects project NNS cord-010092-uftc8inx 3944 20 tend tend VBP cord-010092-uftc8inx 3944 21 to to TO cord-010092-uftc8inx 3944 22 have have VB cord-010092-uftc8inx 3944 23 delayed delay VBN cord-010092-uftc8inx 3944 24 deliverables deliverable NNS cord-010092-uftc8inx 3944 25 . . . cord-010092-uftc8inx 3945 1 The the DT cord-010092-uftc8inx 3945 2 IT IT NNP cord-010092-uftc8inx 3945 3 governance governance NN cord-010092-uftc8inx 3945 4 mechanisms mechanism NNS cord-010092-uftc8inx 3945 5 are be VBP cord-010092-uftc8inx 3945 6 supported support VBN cord-010092-uftc8inx 3945 7 with with IN cord-010092-uftc8inx 3945 8 tools tool NNS cord-010092-uftc8inx 3945 9 such such JJ cord-010092-uftc8inx 3945 10 as as IN cord-010092-uftc8inx 3945 11 service service NN cord-010092-uftc8inx 3945 12 level level NN cord-010092-uftc8inx 3945 13 agreements agreement NNS cord-010092-uftc8inx 3945 14 and and CC cord-010092-uftc8inx 3945 15 established establish VBN cord-010092-uftc8inx 3945 16 communication communication NN cord-010092-uftc8inx 3945 17 approaches approach NNS cord-010092-uftc8inx 3945 18 . . . cord-010092-uftc8inx 3946 1 Simple simple JJ cord-010092-uftc8inx 3946 2 excel excel NNP cord-010092-uftc8inx 3946 3 based base VBN cord-010092-uftc8inx 3946 4 solutions solution NNS cord-010092-uftc8inx 3946 5 are be VBP cord-010092-uftc8inx 3946 6 used use VBN cord-010092-uftc8inx 3946 7 to to TO cord-010092-uftc8inx 3946 8 track track VB cord-010092-uftc8inx 3946 9 critical critical JJ cord-010092-uftc8inx 3946 10 performance performance NN cord-010092-uftc8inx 3946 11 metrics metric NNS cord-010092-uftc8inx 3946 12 such such JJ cord-010092-uftc8inx 3946 13 as as IN cord-010092-uftc8inx 3946 14 on on IN cord-010092-uftc8inx 3946 15 the the DT cord-010092-uftc8inx 3946 16 interactive interactive JJ cord-010092-uftc8inx 3946 17 blood blood NN cord-010092-uftc8inx 3946 18 supply supply NN cord-010092-uftc8inx 3946 19 management management NN cord-010092-uftc8inx 3946 20 status status NN cord-010092-uftc8inx 3946 21 , , , cord-010092-uftc8inx 3946 22 which which WDT cord-010092-uftc8inx 3946 23 averages average VBZ cord-010092-uftc8inx 3946 24 122.8 122.8 CD cord-010092-uftc8inx 3946 25 % % NN cord-010092-uftc8inx 3946 26 ( ( -LRB- cord-010092-uftc8inx 3946 27 2018 2018 CD cord-010092-uftc8inx 3946 28 ) ) -RRB- cord-010092-uftc8inx 3946 29 based base VBN cord-010092-uftc8inx 3946 30 on on IN cord-010092-uftc8inx 3946 31 a a DT cord-010092-uftc8inx 3946 32 5-day 5-day JJ cord-010092-uftc8inx 3946 33 projected project VBN cord-010092-uftc8inx 3946 34 stocking stocking NN cord-010092-uftc8inx 3946 35 and and CC cord-010092-uftc8inx 3946 36 supply supply NN cord-010092-uftc8inx 3946 37 levels level NNS cord-010092-uftc8inx 3946 38 . . . cord-010092-uftc8inx 3947 1 NBSZ NBSZ NNP cord-010092-uftc8inx 3947 2 need need VBP cord-010092-uftc8inx 3947 3 to to TO cord-010092-uftc8inx 3947 4 properly properly RB cord-010092-uftc8inx 3947 5 document document VB cord-010092-uftc8inx 3947 6 the the DT cord-010092-uftc8inx 3947 7 return return NN cord-010092-uftc8inx 3947 8 on on IN cord-010092-uftc8inx 3947 9 investments investment NNS cord-010092-uftc8inx 3947 10 on on IN cord-010092-uftc8inx 3947 11 all all PDT cord-010092-uftc8inx 3947 12 these these DT cord-010092-uftc8inx 3947 13 ICT ICT NNP cord-010092-uftc8inx 3947 14 initiatives initiative NNS cord-010092-uftc8inx 3947 15 , , , cord-010092-uftc8inx 3947 16 which which WDT cord-010092-uftc8inx 3947 17 is be VBZ cord-010092-uftc8inx 3947 18 estimated estimate VBN cord-010092-uftc8inx 3947 19 ( ( -LRB- cord-010092-uftc8inx 3947 20 2016/2017 2016/2017 CD cord-010092-uftc8inx 3947 21 ) ) -RRB- cord-010092-uftc8inx 3947 22 to to TO cord-010092-uftc8inx 3947 23 be be VB cord-010092-uftc8inx 3947 24 at at IN cord-010092-uftc8inx 3947 25 3.2 3.2 CD cord-010092-uftc8inx 3947 26 % % NN cord-010092-uftc8inx 3947 27 of of IN cord-010092-uftc8inx 3947 28 annual annual JJ cord-010092-uftc8inx 3947 29 savings saving NNS cord-010092-uftc8inx 3947 30 . . . cord-010092-uftc8inx 3948 1 Summary Summary NNP cord-010092-uftc8inx 3948 2 / / SYM cord-010092-uftc8inx 3948 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 3948 4 : : : cord-010092-uftc8inx 3949 1 Blood blood NN cord-010092-uftc8inx 3949 2 services service NNS cord-010092-uftc8inx 3949 3 in in IN cord-010092-uftc8inx 3949 4 resource resource NN cord-010092-uftc8inx 3949 5 constrained constrain VBN cord-010092-uftc8inx 3949 6 settings setting NNS cord-010092-uftc8inx 3949 7 can can MD cord-010092-uftc8inx 3949 8 implement implement VB cord-010092-uftc8inx 3949 9 a a DT cord-010092-uftc8inx 3949 10 properly properly RB cord-010092-uftc8inx 3949 11 structured structure VBN cord-010092-uftc8inx 3949 12 IT it NN cord-010092-uftc8inx 3949 13 governance governance NN cord-010092-uftc8inx 3949 14 and and CC cord-010092-uftc8inx 3949 15 this this DT cord-010092-uftc8inx 3949 16 will will MD cord-010092-uftc8inx 3949 17 ensure ensure VB cord-010092-uftc8inx 3949 18 maximum maximum JJ cord-010092-uftc8inx 3949 19 return return NN cord-010092-uftc8inx 3949 20 on on IN cord-010092-uftc8inx 3949 21 IT IT NNP cord-010092-uftc8inx 3949 22 investments investment NNS cord-010092-uftc8inx 3949 23 . . . cord-010092-uftc8inx 3950 1 The the DT cord-010092-uftc8inx 3950 2 NBSZ NBSZ NNP cord-010092-uftc8inx 3950 3 approach approach NN cord-010092-uftc8inx 3950 4 will will MD cord-010092-uftc8inx 3950 5 be be VB cord-010092-uftc8inx 3950 6 shared share VBN cord-010092-uftc8inx 3950 7 and and CC cord-010092-uftc8inx 3950 8 further further RB cord-010092-uftc8inx 3950 9 developed develop VBN cord-010092-uftc8inx 3950 10 in in IN cord-010092-uftc8inx 3950 11 the the DT cord-010092-uftc8inx 3950 12 AfSBT AfSBT NNP cord-010092-uftc8inx 3950 13 ITWG ITWG NNP cord-010092-uftc8inx 3950 14 to to TO cord-010092-uftc8inx 3950 15 support support VB cord-010092-uftc8inx 3950 16 other other JJ cord-010092-uftc8inx 3950 17 blood blood NN cord-010092-uftc8inx 3950 18 services service NNS cord-010092-uftc8inx 3950 19 in in IN cord-010092-uftc8inx 3950 20 improving improve VBG cord-010092-uftc8inx 3950 21 their -PRON- PRP$ cord-010092-uftc8inx 3950 22 IT IT NNP cord-010092-uftc8inx 3950 23 governance governance NN cord-010092-uftc8inx 3950 24 . . . cord-010092-uftc8inx 3951 1 Haematology Haematology NNP cord-010092-uftc8inx 3951 2 / / SYM cord-010092-uftc8inx 3951 3 Blood Blood NNP cord-010092-uftc8inx 3951 4 Transfusion Transfusion NNP cord-010092-uftc8inx 3951 5 , , , cord-010092-uftc8inx 3951 6 Alfred Alfred NNP cord-010092-uftc8inx 3951 7 Health Health NNP cord-010092-uftc8inx 3951 8 , , , cord-010092-uftc8inx 3951 9 Melbourne Melbourne NNP cord-010092-uftc8inx 3952 1 , , , cord-010092-uftc8inx 3952 2 Australia Australia NNP cord-010092-uftc8inx 3952 3 Background Background NNP cord-010092-uftc8inx 3952 4 : : : cord-010092-uftc8inx 3953 1 In in IN cord-010092-uftc8inx 3953 2 October October NNP cord-010092-uftc8inx 3953 3 2018 2018 CD cord-010092-uftc8inx 3953 4 , , , cord-010092-uftc8inx 3953 5 an an DT cord-010092-uftc8inx 3953 6 integrated integrate VBN cord-010092-uftc8inx 3953 7 electronic electronic JJ cord-010092-uftc8inx 3953 8 medical medical JJ cord-010092-uftc8inx 3953 9 record record NN cord-010092-uftc8inx 3953 10 ( ( -LRB- cord-010092-uftc8inx 3953 11 EMR EMR NNP cord-010092-uftc8inx 3953 12 ) ) -RRB- cord-010092-uftc8inx 3953 13 was be VBD cord-010092-uftc8inx 3953 14 implemented implement VBN cord-010092-uftc8inx 3953 15 at at IN cord-010092-uftc8inx 3953 16 an an DT cord-010092-uftc8inx 3953 17 Australian australian JJ cord-010092-uftc8inx 3953 18 metropolitan metropolitan JJ cord-010092-uftc8inx 3953 19 multi multi JJ cord-010092-uftc8inx 3953 20 - - JJ cord-010092-uftc8inx 3953 21 campus campus JJ cord-010092-uftc8inx 3953 22 heath heath NNP cord-010092-uftc8inx 3953 23 service service NN cord-010092-uftc8inx 3953 24 using use VBG cord-010092-uftc8inx 3953 25 Cerner Cerner NNP cord-010092-uftc8inx 3953 26 Millennium Millennium NNP cord-010092-uftc8inx 3953 27 TM TM NNP cord-010092-uftc8inx 3953 28 , , , cord-010092-uftc8inx 3953 29 aiming aim VBG cord-010092-uftc8inx 3953 30 to to TO cord-010092-uftc8inx 3953 31 achieve achieve VB cord-010092-uftc8inx 3953 32 HIMSS HIMSS NNP cord-010092-uftc8inx 3953 33 ( ( -LRB- cord-010092-uftc8inx 3953 34 Healthcare Healthcare NNP cord-010092-uftc8inx 3953 35 Information Information NNP cord-010092-uftc8inx 3953 36 and and CC cord-010092-uftc8inx 3953 37 Management Management NNP cord-010092-uftc8inx 3953 38 Systems Systems NNPS cord-010092-uftc8inx 3953 39 Society Society NNP cord-010092-uftc8inx 3953 40 ) ) -RRB- cord-010092-uftc8inx 3953 41 level level NN cord-010092-uftc8inx 3953 42 6 6 CD cord-010092-uftc8inx 3953 43 . . . cord-010092-uftc8inx 3954 1 Prior prior RB cord-010092-uftc8inx 3954 2 to to IN cord-010092-uftc8inx 3954 3 implementation implementation NN cord-010092-uftc8inx 3954 4 , , , cord-010092-uftc8inx 3954 5 large large JJ cord-010092-uftc8inx 3954 6 numbers number NNS cord-010092-uftc8inx 3954 7 of of IN cord-010092-uftc8inx 3954 8 blood blood NN cord-010092-uftc8inx 3954 9 specimens specimen NNS cord-010092-uftc8inx 3954 10 were be VBD cord-010092-uftc8inx 3954 11 collected collect VBN cord-010092-uftc8inx 3954 12 from from IN cord-010092-uftc8inx 3954 13 patients patient NNS cord-010092-uftc8inx 3954 14 unnecessarily unnecessarily RB cord-010092-uftc8inx 3954 15 and and CC cord-010092-uftc8inx 3954 16 sent send VBN cord-010092-uftc8inx 3954 17 to to IN cord-010092-uftc8inx 3954 18 Pathology Pathology NNP cord-010092-uftc8inx 3954 19 without without IN cord-010092-uftc8inx 3954 20 a a DT cord-010092-uftc8inx 3954 21 test test NN cord-010092-uftc8inx 3954 22 request request NN cord-010092-uftc8inx 3954 23 attached attach VBN cord-010092-uftc8inx 3954 24 ( ( -LRB- cord-010092-uftc8inx 3954 25 no no DT cord-010092-uftc8inx 3954 26 blood blood NN cord-010092-uftc8inx 3954 27 test test NN cord-010092-uftc8inx 3954 28 requested request VBD cord-010092-uftc8inx 3954 29 -NTR -NTR VBG cord-010092-uftc8inx 3954 30 ) ) -RRB- cord-010092-uftc8inx 3954 31 . . . cord-010092-uftc8inx 3955 1 These these DT cord-010092-uftc8inx 3955 2 specimens specimen NNS cord-010092-uftc8inx 3955 3 required require VBD cord-010092-uftc8inx 3955 4 additional additional JJ cord-010092-uftc8inx 3955 5 processing processing NN cord-010092-uftc8inx 3955 6 in in IN cord-010092-uftc8inx 3955 7 the the DT cord-010092-uftc8inx 3955 8 laboratory laboratory NN cord-010092-uftc8inx 3955 9 . . . cord-010092-uftc8inx 3956 1 Electronic electronic JJ cord-010092-uftc8inx 3956 2 specimen specimen NN cord-010092-uftc8inx 3956 3 collection collection NN cord-010092-uftc8inx 3956 4 using use VBG cord-010092-uftc8inx 3956 5 Cerner Cerner NNP cord-010092-uftc8inx 3956 6 Specimen Specimen NNP cord-010092-uftc8inx 3956 7 Collect Collect NNP cord-010092-uftc8inx 3956 8 TM TM NNP cord-010092-uftc8inx 3956 9 allowed allow VBD cord-010092-uftc8inx 3956 10 streamlining streamline VBG cord-010092-uftc8inx 3956 11 of of IN cord-010092-uftc8inx 3956 12 specimen specimen JJ cord-010092-uftc8inx 3956 13 processing processing NN cord-010092-uftc8inx 3956 14 by by IN cord-010092-uftc8inx 3956 15 eliminating eliminate VBG cord-010092-uftc8inx 3956 16 paper paper NN cord-010092-uftc8inx 3956 17 requests request NNS cord-010092-uftc8inx 3956 18 . . . cord-010092-uftc8inx 3957 1 As as IN cord-010092-uftc8inx 3957 2 part part NN cord-010092-uftc8inx 3957 3 of of IN cord-010092-uftc8inx 3957 4 the the DT cord-010092-uftc8inx 3957 5 new new JJ cord-010092-uftc8inx 3957 6 workflow workflow NN cord-010092-uftc8inx 3957 7 , , , cord-010092-uftc8inx 3957 8 individual individual JJ cord-010092-uftc8inx 3957 9 specimen specimen NN cord-010092-uftc8inx 3957 10 labels label NNS cord-010092-uftc8inx 3957 11 are be VBP cord-010092-uftc8inx 3957 12 printed print VBN cord-010092-uftc8inx 3957 13 with with IN cord-010092-uftc8inx 3957 14 the the DT cord-010092-uftc8inx 3957 15 specified specify VBN cord-010092-uftc8inx 3957 16 blood blood NN cord-010092-uftc8inx 3957 17 test test NN cord-010092-uftc8inx 3957 18 and and CC cord-010092-uftc8inx 3957 19 correct correct JJ cord-010092-uftc8inx 3957 20 tube tube NN cord-010092-uftc8inx 3957 21 type type NN cord-010092-uftc8inx 3957 22 . . . cord-010092-uftc8inx 3958 1 This this DT cord-010092-uftc8inx 3958 2 helps help VBZ cord-010092-uftc8inx 3958 3 prevent prevent VB cord-010092-uftc8inx 3958 4 the the DT cord-010092-uftc8inx 3958 5 practice practice NN cord-010092-uftc8inx 3958 6 of of IN cord-010092-uftc8inx 3958 7 collecting collect VBG cord-010092-uftc8inx 3958 8 additional additional JJ cord-010092-uftc8inx 3958 9 specimens specimen NNS cord-010092-uftc8inx 3958 10 due due JJ cord-010092-uftc8inx 3958 11 to to IN cord-010092-uftc8inx 3958 12 uncertainty uncertainty NN cord-010092-uftc8inx 3958 13 of of IN cord-010092-uftc8inx 3958 14 the the DT cord-010092-uftc8inx 3958 15 collection collection NN cord-010092-uftc8inx 3958 16 requirements requirement NNS cord-010092-uftc8inx 3958 17 . . . cord-010092-uftc8inx 3959 1 Aims aim VBZ cord-010092-uftc8inx 3959 2 : : : cord-010092-uftc8inx 3959 3 • • XX cord-010092-uftc8inx 3960 1 To to TO cord-010092-uftc8inx 3960 2 quantify quantify VB cord-010092-uftc8inx 3960 3 the the DT cord-010092-uftc8inx 3960 4 expected expect VBN cord-010092-uftc8inx 3960 5 reduction reduction NN cord-010092-uftc8inx 3960 6 in in IN cord-010092-uftc8inx 3960 7 NTR NTR NNP cord-010092-uftc8inx 3960 8 specimens specimen NNS cord-010092-uftc8inx 3960 9 following follow VBG cord-010092-uftc8inx 3960 10 introduction introduction NN cord-010092-uftc8inx 3960 11 of of IN cord-010092-uftc8inx 3960 12 electronic electronic JJ cord-010092-uftc8inx 3960 13 specimen specimen NN cord-010092-uftc8inx 3960 14 collection collection NN cord-010092-uftc8inx 3960 15 , , , cord-010092-uftc8inx 3960 16 and and CC cord-010092-uftc8inx 3960 17 outline outline VB cord-010092-uftc8inx 3960 18 the the DT cord-010092-uftc8inx 3960 19 benefits benefit NNS cord-010092-uftc8inx 3961 1 • • NNP cord-010092-uftc8inx 3962 1 To to TO cord-010092-uftc8inx 3962 2 determine determine VB cord-010092-uftc8inx 3962 3 the the DT cord-010092-uftc8inx 3962 4 impact impact NN cord-010092-uftc8inx 3962 5 on on IN cord-010092-uftc8inx 3962 6 collection collection NN cord-010092-uftc8inx 3962 7 errors error NNS cord-010092-uftc8inx 3962 8 and and CC cord-010092-uftc8inx 3962 9 Wrong wrong JJ cord-010092-uftc8inx 3962 10 Blood blood NN cord-010092-uftc8inx 3963 1 In in IN cord-010092-uftc8inx 3963 2 Tube tube NN cord-010092-uftc8inx 3963 3 ( ( -LRB- cord-010092-uftc8inx 3963 4 WBIT WBIT NNP cord-010092-uftc8inx 3963 5 ) ) -RRB- cord-010092-uftc8inx 3964 1 events event NNS cord-010092-uftc8inx 3964 2 Methods method NNS cord-010092-uftc8inx 3964 3 : : : cord-010092-uftc8inx 3965 1 Data datum NNS cord-010092-uftc8inx 3965 2 was be VBD cord-010092-uftc8inx 3965 3 obtained obtain VBN cord-010092-uftc8inx 3965 4 directly directly RB cord-010092-uftc8inx 3965 5 from from IN cord-010092-uftc8inx 3965 6 Cerner Cerner NNP cord-010092-uftc8inx 3965 7 Millennium Millennium NNP cord-010092-uftc8inx 3965 8 TM TM NNP cord-010092-uftc8inx 3965 9 using use VBG cord-010092-uftc8inx 3965 10 a a DT cord-010092-uftc8inx 3965 11 CCL CCL NNP cord-010092-uftc8inx 3965 12 ( ( -LRB- cord-010092-uftc8inx 3965 13 Cerner Cerner NNP cord-010092-uftc8inx 3965 14 Command Command NNP cord-010092-uftc8inx 3965 15 Language Language NNP cord-010092-uftc8inx 3965 16 ) ) -RRB- cord-010092-uftc8inx 3965 17 query query NN cord-010092-uftc8inx 3965 18 which which WDT cord-010092-uftc8inx 3965 19 is be VBZ cord-010092-uftc8inx 3965 20 run run VBN cord-010092-uftc8inx 3965 21 monthly monthly RB cord-010092-uftc8inx 3965 22 by by IN cord-010092-uftc8inx 3965 23 Pathology Pathology NNP cord-010092-uftc8inx 3965 24 IT IT NNP cord-010092-uftc8inx 3965 25 staff staff NN cord-010092-uftc8inx 3965 26 . . . cord-010092-uftc8inx 3966 1 This this DT cord-010092-uftc8inx 3966 2 data data NN cord-010092-uftc8inx 3966 3 includes include VBZ cord-010092-uftc8inx 3966 4 all all DT cord-010092-uftc8inx 3966 5 specimens specimen NNS cord-010092-uftc8inx 3966 6 registered register VBN cord-010092-uftc8inx 3966 7 for for IN cord-010092-uftc8inx 3966 8 the the DT cord-010092-uftc8inx 3966 9 month month NN cord-010092-uftc8inx 3966 10 with with IN cord-010092-uftc8inx 3966 11 indication indication NN cord-010092-uftc8inx 3966 12 of of IN cord-010092-uftc8inx 3966 13 rejected reject VBN cord-010092-uftc8inx 3966 14 specimens specimen NNS cord-010092-uftc8inx 3966 15 , , , cord-010092-uftc8inx 3966 16 WBIT WBIT NNP cord-010092-uftc8inx 3966 17 & & CC cord-010092-uftc8inx 3966 18 NTR NTR NNP cord-010092-uftc8inx 3966 19 samples sample NNS cord-010092-uftc8inx 3966 20 . . . cord-010092-uftc8inx 3966 21 ' ' '' cord-010092-uftc8inx 3967 1 Rejected reject VBN cord-010092-uftc8inx 3967 2 specimens specimen NNS cord-010092-uftc8inx 3967 3 ' ' POS cord-010092-uftc8inx 3967 4 includes include VBZ cord-010092-uftc8inx 3967 5 incomplete incomplete JJ cord-010092-uftc8inx 3967 6 specimen specimen NN cord-010092-uftc8inx 3967 7 and/or and/or CC cord-010092-uftc8inx 3967 8 request request NN cord-010092-uftc8inx 3967 9 certification certification NN cord-010092-uftc8inx 3967 10 , , , cord-010092-uftc8inx 3967 11 unlabelled unlabelled JJ cord-010092-uftc8inx 3967 12 specimens specimen NNS cord-010092-uftc8inx 3967 13 / / SYM cord-010092-uftc8inx 3967 14 requests request NNS cord-010092-uftc8inx 3967 15 and and CC cord-010092-uftc8inx 3967 16 mismatched mismatched JJ cord-010092-uftc8inx 3967 17 specimens specimen NNS cord-010092-uftc8inx 3967 18 . . . cord-010092-uftc8inx 3968 1 Further further JJ cord-010092-uftc8inx 3968 2 information information NN cord-010092-uftc8inx 3968 3 about about IN cord-010092-uftc8inx 3968 4 WBIT WBIT NNP cord-010092-uftc8inx 3968 5 events event NNS cord-010092-uftc8inx 3968 6 was be VBD cord-010092-uftc8inx 3968 7 collated collate VBN cord-010092-uftc8inx 3968 8 from from IN cord-010092-uftc8inx 3968 9 Riskman Riskman NNP cord-010092-uftc8inx 3968 10 reports report NNS cord-010092-uftc8inx 3968 11 and and CC cord-010092-uftc8inx 3968 12 staff staff NN cord-010092-uftc8inx 3968 13 interviews interview NNS cord-010092-uftc8inx 3968 14 . . . cord-010092-uftc8inx 3969 1 Results result NNS cord-010092-uftc8inx 3969 2 : : : cord-010092-uftc8inx 3970 1 Data datum NNS cord-010092-uftc8inx 3970 2 from from IN cord-010092-uftc8inx 3970 3 the the DT cord-010092-uftc8inx 3970 4 12 12 CD cord-010092-uftc8inx 3970 5 months month NNS cord-010092-uftc8inx 3970 6 prior prior RB cord-010092-uftc8inx 3970 7 to to IN cord-010092-uftc8inx 3970 8 EMR EMR NNP cord-010092-uftc8inx 3970 9 implementation implementation NN cord-010092-uftc8inx 3970 10 was be VBD cord-010092-uftc8inx 3970 11 compared compare VBN cord-010092-uftc8inx 3970 12 with with IN cord-010092-uftc8inx 3970 13 3 3 CD cord-010092-uftc8inx 3970 14 months month NNS cord-010092-uftc8inx 3970 15 post post NN cord-010092-uftc8inx 3970 16 . . . cord-010092-uftc8inx 3971 1 NTR NTR NNP cord-010092-uftc8inx 3971 2 numbers number NNS cord-010092-uftc8inx 3971 3 reduced reduce VBN cord-010092-uftc8inx 3971 4 from from IN cord-010092-uftc8inx 3971 5 4220 4220 CD cord-010092-uftc8inx 3971 6 / / SYM cord-010092-uftc8inx 3971 7 month month NN cord-010092-uftc8inx 3971 8 to to IN cord-010092-uftc8inx 3971 9 2019 2019 CD cord-010092-uftc8inx 3971 10 / / SYM cord-010092-uftc8inx 3971 11 month month NN cord-010092-uftc8inx 3971 12 ( ( -LRB- cord-010092-uftc8inx 3971 13 52 52 CD cord-010092-uftc8inx 3971 14 % % NN cord-010092-uftc8inx 3971 15 reduction reduction NN cord-010092-uftc8inx 3971 16 ) ) -RRB- cord-010092-uftc8inx 3971 17 , , , cord-010092-uftc8inx 3971 18 freeing free VBG cord-010092-uftc8inx 3971 19 up up RP cord-010092-uftc8inx 3971 20 more more JJR cord-010092-uftc8inx 3971 21 storage storage NN cord-010092-uftc8inx 3971 22 space space NN cord-010092-uftc8inx 3971 23 in in IN cord-010092-uftc8inx 3971 24 fridges fridge NNS cord-010092-uftc8inx 3971 25 . . . cord-010092-uftc8inx 3972 1 Rejected reject VBN cord-010092-uftc8inx 3972 2 specimens specimen NNS cord-010092-uftc8inx 3972 3 due due JJ cord-010092-uftc8inx 3972 4 to to IN cord-010092-uftc8inx 3972 5 inadequate inadequate JJ cord-010092-uftc8inx 3972 6 patient patient NN cord-010092-uftc8inx 3972 7 request request NN cord-010092-uftc8inx 3972 8 labelling labelling NN cord-010092-uftc8inx 3972 9 reduced reduce VBN cord-010092-uftc8inx 3972 10 from from IN cord-010092-uftc8inx 3972 11 a a DT cord-010092-uftc8inx 3972 12 mean mean NN cord-010092-uftc8inx 3972 13 of of IN cord-010092-uftc8inx 3972 14 27 27 CD cord-010092-uftc8inx 3972 15 / / SYM cord-010092-uftc8inx 3972 16 mth mth NN cord-010092-uftc8inx 3972 17 to to IN cord-010092-uftc8inx 3972 18 6 6 CD cord-010092-uftc8inx 3972 19 / / SYM cord-010092-uftc8inx 3972 20 mth mth NN cord-010092-uftc8inx 3972 21 . . . cord-010092-uftc8inx 3973 1 WBIT WBIT NNP cord-010092-uftc8inx 3973 2 numbers number NNS cord-010092-uftc8inx 3973 3 have have VBP cord-010092-uftc8inx 3973 4 increased increase VBN cord-010092-uftc8inx 3973 5 slightly slightly RB cord-010092-uftc8inx 3973 6 : : : cord-010092-uftc8inx 3973 7 before before IN cord-010092-uftc8inx 3973 8 having have VBG cord-010092-uftc8inx 3973 9 median median JJ cord-010092-uftc8inx 3973 10 1 1 CD cord-010092-uftc8inx 3973 11 ( ( -LRB- cord-010092-uftc8inx 3973 12 range range NN cord-010092-uftc8inx 3973 13 0 0 CD cord-010092-uftc8inx 3973 14 - - SYM cord-010092-uftc8inx 3973 15 2 2 CD cord-010092-uftc8inx 3973 16 ) ) -RRB- cord-010092-uftc8inx 3973 17 , , , cord-010092-uftc8inx 3973 18 after after IN cord-010092-uftc8inx 3973 19 with with IN cord-010092-uftc8inx 3973 20 median median JJ cord-010092-uftc8inx 3973 21 2 2 CD cord-010092-uftc8inx 3974 1 ( ( -LRB- cord-010092-uftc8inx 3974 2 range range NN cord-010092-uftc8inx 3974 3 0 0 CD cord-010092-uftc8inx 3974 4 - - SYM cord-010092-uftc8inx 3974 5 3 3 CD cord-010092-uftc8inx 3974 6 ) ) -RRB- cord-010092-uftc8inx 3974 7 . . . cord-010092-uftc8inx 3975 1 Although although IN cord-010092-uftc8inx 3975 2 it -PRON- PRP cord-010092-uftc8inx 3975 3 was be VBD cord-010092-uftc8inx 3975 4 hoped hope VBN cord-010092-uftc8inx 3975 5 that that IN cord-010092-uftc8inx 3975 6 WBIT WBIT NNP cord-010092-uftc8inx 3975 7 incidence incidence NN cord-010092-uftc8inx 3975 8 may may MD cord-010092-uftc8inx 3975 9 reduce reduce VB cord-010092-uftc8inx 3975 10 with with IN cord-010092-uftc8inx 3975 11 the the DT cord-010092-uftc8inx 3975 12 new new JJ cord-010092-uftc8inx 3975 13 EMR EMR NNP cord-010092-uftc8inx 3975 14 , , , cord-010092-uftc8inx 3975 15 4 4 CD cord-010092-uftc8inx 3975 16 of of IN cord-010092-uftc8inx 3975 17 the the DT cord-010092-uftc8inx 3975 18 post post NN cord-010092-uftc8inx 3975 19 implementation implementation NN cord-010092-uftc8inx 3975 20 6 6 CD cord-010092-uftc8inx 3975 21 WBITs wbit NNS cord-010092-uftc8inx 3975 22 involved involve VBD cord-010092-uftc8inx 3975 23 electronic electronic JJ cord-010092-uftc8inx 3975 24 specimen specimen NN cord-010092-uftc8inx 3975 25 collection collection NN cord-010092-uftc8inx 3975 26 . . . cord-010092-uftc8inx 3976 1 Departure departure NN cord-010092-uftc8inx 3976 2 from from IN cord-010092-uftc8inx 3976 3 planned plan VBN cord-010092-uftc8inx 3976 4 protocols protocol NNS cord-010092-uftc8inx 3976 5 involving involve VBG cord-010092-uftc8inx 3976 6 a a DT cord-010092-uftc8inx 3976 7 lack lack NN cord-010092-uftc8inx 3976 8 of of IN cord-010092-uftc8inx 3976 9 working work VBG cord-010092-uftc8inx 3976 10 printers printer NNS cord-010092-uftc8inx 3976 11 , , , cord-010092-uftc8inx 3976 12 causing cause VBG cord-010092-uftc8inx 3976 13 staff staff NN cord-010092-uftc8inx 3976 14 to to TO cord-010092-uftc8inx 3976 15 print print VB cord-010092-uftc8inx 3976 16 patient patient NN cord-010092-uftc8inx 3976 17 labels label NNS cord-010092-uftc8inx 3976 18 away away RB cord-010092-uftc8inx 3976 19 from from IN cord-010092-uftc8inx 3976 20 the the DT cord-010092-uftc8inx 3976 21 patient patient NN cord-010092-uftc8inx 3976 22 's 's POS cord-010092-uftc8inx 3976 23 bedside bedside NN cord-010092-uftc8inx 3976 24 , , , cord-010092-uftc8inx 3976 25 as as RB cord-010092-uftc8inx 3976 26 well well RB cord-010092-uftc8inx 3976 27 as as IN cord-010092-uftc8inx 3976 28 multiple multiple JJ cord-010092-uftc8inx 3976 29 patient patient NN cord-010092-uftc8inx 3976 30 labels label NNS cord-010092-uftc8inx 3976 31 printing print VBG cord-010092-uftc8inx 3976 32 on on IN cord-010092-uftc8inx 3976 33 individual individual JJ cord-010092-uftc8inx 3976 34 printers printer NNS cord-010092-uftc8inx 3976 35 appear appear VBP cord-010092-uftc8inx 3976 36 to to TO cord-010092-uftc8inx 3976 37 be be VB cord-010092-uftc8inx 3976 38 a a DT cord-010092-uftc8inx 3976 39 main main JJ cord-010092-uftc8inx 3976 40 cause cause NN cord-010092-uftc8inx 3976 41 of of IN cord-010092-uftc8inx 3976 42 the the DT cord-010092-uftc8inx 3976 43 EMR EMR NNP cord-010092-uftc8inx 3976 44 WBITs wbit NNS cord-010092-uftc8inx 3976 45 . . . cord-010092-uftc8inx 3977 1 Summary Summary NNP cord-010092-uftc8inx 3977 2 / / SYM cord-010092-uftc8inx 3977 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 3977 4 : : : cord-010092-uftc8inx 3978 1 EMR EMR NNP cord-010092-uftc8inx 3978 2 implementation implementation NN cord-010092-uftc8inx 3978 3 has have VBZ cord-010092-uftc8inx 3978 4 led lead VBN cord-010092-uftc8inx 3978 5 to to IN cord-010092-uftc8inx 3978 6 a a DT cord-010092-uftc8inx 3978 7 reduction reduction NN cord-010092-uftc8inx 3978 8 in in IN cord-010092-uftc8inx 3978 9 NTR NTR NNP cord-010092-uftc8inx 3978 10 , , , cord-010092-uftc8inx 3978 11 and and CC cord-010092-uftc8inx 3978 12 rejected reject VBD cord-010092-uftc8inx 3978 13 specimens specimen NNS cord-010092-uftc8inx 3978 14 due due JJ cord-010092-uftc8inx 3978 15 to to IN cord-010092-uftc8inx 3978 16 inadequate inadequate JJ cord-010092-uftc8inx 3978 17 request request NN cord-010092-uftc8inx 3978 18 labelling labelling NN cord-010092-uftc8inx 3978 19 , , , cord-010092-uftc8inx 3978 20 as as RB cord-010092-uftc8inx 3978 21 well well RB cord-010092-uftc8inx 3978 22 as as IN cord-010092-uftc8inx 3978 23 increased increase VBN cord-010092-uftc8inx 3978 24 storage storage NN cord-010092-uftc8inx 3978 25 space space NN cord-010092-uftc8inx 3978 26 in in IN cord-010092-uftc8inx 3978 27 laboratory laboratory NN cord-010092-uftc8inx 3978 28 refrigerators refrigerator NNS cord-010092-uftc8inx 3978 29 . . . cord-010092-uftc8inx 3979 1 Associated associated JJ cord-010092-uftc8inx 3979 2 benefits benefit NNS cord-010092-uftc8inx 3979 3 include include VBP cord-010092-uftc8inx 3979 4 : : : cord-010092-uftc8inx 3979 5 • • XX cord-010092-uftc8inx 3980 1 Decreased decrease VBN cord-010092-uftc8inx 3980 2 financial financial JJ cord-010092-uftc8inx 3980 3 costs cost NNS cord-010092-uftc8inx 3980 4 of of IN cord-010092-uftc8inx 3980 5 the the DT cord-010092-uftc8inx 3980 6 wasted waste VBN cord-010092-uftc8inx 3980 7 equipment equipment NN cord-010092-uftc8inx 3981 1 • • NNP cord-010092-uftc8inx 3982 1 Decreased decrease VBN cord-010092-uftc8inx 3982 2 staff staff NN cord-010092-uftc8inx 3982 3 time time NN cord-010092-uftc8inx 3982 4 collecting collect VBG cord-010092-uftc8inx 3982 5 and and CC cord-010092-uftc8inx 3982 6 processing process VBG cord-010092-uftc8inx 3982 7 unusable unusable JJ cord-010092-uftc8inx 3982 8 specimens specimen NNS cord-010092-uftc8inx 3983 1 • • NNP cord-010092-uftc8inx 3983 2 Decreased decrease VBD cord-010092-uftc8inx 3983 3 environmental environmental JJ cord-010092-uftc8inx 3983 4 impact impact NN cord-010092-uftc8inx 3983 5 of of IN cord-010092-uftc8inx 3983 6 manufacture manufacture NN cord-010092-uftc8inx 3983 7 and and CC cord-010092-uftc8inx 3983 8 disposal disposal NN cord-010092-uftc8inx 3983 9 of of IN cord-010092-uftc8inx 3983 10 unused unused JJ cord-010092-uftc8inx 3983 11 specimens specimen NNS cord-010092-uftc8inx 3984 1 • • NNP cord-010092-uftc8inx 3985 1 Decreased decrease VBN cord-010092-uftc8inx 3985 2 potential potential NN cord-010092-uftc8inx 3985 3 of of IN cord-010092-uftc8inx 3985 4 iatrogenic iatrogenic JJ cord-010092-uftc8inx 3985 5 anaemia anaemia NN cord-010092-uftc8inx 3985 6 Work work VB cord-010092-uftc8inx 3985 7 in in IN cord-010092-uftc8inx 3985 8 preventing prevent VBG cord-010092-uftc8inx 3985 9 the the DT cord-010092-uftc8inx 3985 10 occurrence occurrence NN cord-010092-uftc8inx 3985 11 of of IN cord-010092-uftc8inx 3985 12 further further JJ cord-010092-uftc8inx 3985 13 WBITs wbit NNS cord-010092-uftc8inx 3985 14 is be VBZ cord-010092-uftc8inx 3985 15 ongoing ongoing JJ cord-010092-uftc8inx 3985 16 , , , cord-010092-uftc8inx 3985 17 by by IN cord-010092-uftc8inx 3985 18 ensuring ensure VBG cord-010092-uftc8inx 3985 19 that that IN cord-010092-uftc8inx 3985 20 label label NN cord-010092-uftc8inx 3985 21 printers printer NNS cord-010092-uftc8inx 3985 22 are be VBP cord-010092-uftc8inx 3985 23 in in IN cord-010092-uftc8inx 3985 24 working work VBG cord-010092-uftc8inx 3985 25 order order NN cord-010092-uftc8inx 3985 26 , , , cord-010092-uftc8inx 3985 27 are be VBP cord-010092-uftc8inx 3985 28 in in IN cord-010092-uftc8inx 3985 29 plentiful plentiful JJ cord-010092-uftc8inx 3985 30 supply supply NN cord-010092-uftc8inx 3985 31 and and CC cord-010092-uftc8inx 3985 32 easily easily RB cord-010092-uftc8inx 3985 33 accessible accessible JJ cord-010092-uftc8inx 3985 34 to to IN cord-010092-uftc8inx 3985 35 staff staff NN cord-010092-uftc8inx 3985 36 ; ; : cord-010092-uftc8inx 3985 37 and and CC cord-010092-uftc8inx 3985 38 also also RB cord-010092-uftc8inx 3985 39 ensuring ensure VBG cord-010092-uftc8inx 3985 40 positive positive JJ cord-010092-uftc8inx 3985 41 patient patient JJ cord-010092-uftc8inx 3985 42 identification identification NN cord-010092-uftc8inx 3985 43 and and CC cord-010092-uftc8inx 3985 44 blood blood NN cord-010092-uftc8inx 3985 45 collection collection NN cord-010092-uftc8inx 3985 46 by by IN cord-010092-uftc8inx 3985 47 the the DT cord-010092-uftc8inx 3985 48 patient patient NN cord-010092-uftc8inx 3985 49 's 's POS cord-010092-uftc8inx 3985 50 bedside bedside NN cord-010092-uftc8inx 3985 51 remains remain VBZ cord-010092-uftc8inx 3985 52 a a DT cord-010092-uftc8inx 3985 53 priority priority NN cord-010092-uftc8inx 3985 54 . . . cord-010092-uftc8inx 3986 1 JM JM NNP cord-010092-uftc8inx 3986 2 Mustaffa Mustaffa NNP cord-010092-uftc8inx 3986 3 1 1 CD cord-010092-uftc8inx 3986 4 , , , cord-010092-uftc8inx 3986 5 K K NNP cord-010092-uftc8inx 3986 6 Teo Teo NNP cord-010092-uftc8inx 3986 7 2 2 CD cord-010092-uftc8inx 3986 8 , , , cord-010092-uftc8inx 3986 9 S S NNP cord-010092-uftc8inx 3986 10 Tsai Tsai NNP cord-010092-uftc8inx 3986 11 1 1 CD cord-010092-uftc8inx 3986 12 , , , cord-010092-uftc8inx 3986 13 P P NNP cord-010092-uftc8inx 3986 14 Heng Heng NNP cord-010092-uftc8inx 3986 15 1 1 CD cord-010092-uftc8inx 3986 16 , , , cord-010092-uftc8inx 3986 17 R R NNP cord-010092-uftc8inx 3986 18 Sagun Sagun NNP cord-010092-uftc8inx 3986 19 1 1 CD cord-010092-uftc8inx 3986 20 and and CC cord-010092-uftc8inx 3986 21 M M NNP cord-010092-uftc8inx 3986 22 Wong Wong NNP cord-010092-uftc8inx 3986 23 1 1 CD cord-010092-uftc8inx 3986 24 1 1 CD cord-010092-uftc8inx 3986 25 Laboratory Laboratory NNP cord-010092-uftc8inx 3986 26 Medicine Medicine NNP cord-010092-uftc8inx 3986 27 2 2 CD cord-010092-uftc8inx 3986 28 Khoo Khoo NNP cord-010092-uftc8inx 3986 29 Teck Teck NNP cord-010092-uftc8inx 3986 30 Puat Puat NNP cord-010092-uftc8inx 3986 31 Hospital Hospital NNP cord-010092-uftc8inx 3986 32 , , , cord-010092-uftc8inx 3986 33 Singapore Singapore NNP cord-010092-uftc8inx 3986 34 , , , cord-010092-uftc8inx 3987 1 Singapore Singapore NNP cord-010092-uftc8inx 3987 2 Background Background NNP cord-010092-uftc8inx 3987 3 : : : cord-010092-uftc8inx 3987 4 Khoo Khoo NNP cord-010092-uftc8inx 3987 5 Teck Teck NNP cord-010092-uftc8inx 3987 6 Puat Puat NNP cord-010092-uftc8inx 3987 7 Hospital Hospital NNP cord-010092-uftc8inx 3987 8 ( ( -LRB- cord-010092-uftc8inx 3987 9 KTPH KTPH NNP cord-010092-uftc8inx 3987 10 ) ) -RRB- cord-010092-uftc8inx 3987 11 is be VBZ cord-010092-uftc8inx 3987 12 a a DT cord-010092-uftc8inx 3987 13 761-bed 761-bed CD cord-010092-uftc8inx 3987 14 general general JJ cord-010092-uftc8inx 3987 15 and and CC cord-010092-uftc8inx 3987 16 acute acute JJ cord-010092-uftc8inx 3987 17 care care NN cord-010092-uftc8inx 3987 18 hospital hospital NN cord-010092-uftc8inx 3987 19 , , , cord-010092-uftc8inx 3987 20 opened open VBN cord-010092-uftc8inx 3987 21 in in IN cord-010092-uftc8inx 3987 22 2010 2010 CD cord-010092-uftc8inx 3987 23 , , , cord-010092-uftc8inx 3987 24 serving serve VBG cord-010092-uftc8inx 3987 25 more more JJR cord-010092-uftc8inx 3987 26 than than IN cord-010092-uftc8inx 3987 27 800,000 800,000 CD cord-010092-uftc8inx 3987 28 people people NNS cord-010092-uftc8inx 3987 29 living live VBG cord-010092-uftc8inx 3987 30 in in IN cord-010092-uftc8inx 3987 31 the the DT cord-010092-uftc8inx 3987 32 northern northern JJ cord-010092-uftc8inx 3987 33 sector sector NN cord-010092-uftc8inx 3987 34 of of IN cord-010092-uftc8inx 3987 35 Singapore Singapore NNP cord-010092-uftc8inx 3987 36 . . . cord-010092-uftc8inx 3988 1 The the DT cord-010092-uftc8inx 3988 2 Blood Blood NNP cord-010092-uftc8inx 3988 3 Bank Bank NNP cord-010092-uftc8inx 3988 4 of of IN cord-010092-uftc8inx 3988 5 KTPH KTPH NNP cord-010092-uftc8inx 3988 6 Department Department NNP cord-010092-uftc8inx 3988 7 of of IN cord-010092-uftc8inx 3988 8 Laboratory Laboratory NNP cord-010092-uftc8inx 3988 9 Medicine Medicine NNP cord-010092-uftc8inx 3988 10 provides provide VBZ cord-010092-uftc8inx 3988 11 specimen specimen JJ cord-010092-uftc8inx 3988 12 testing testing NN cord-010092-uftc8inx 3988 13 and and CC cord-010092-uftc8inx 3988 14 blood blood NN cord-010092-uftc8inx 3988 15 transfusion transfusion NN cord-010092-uftc8inx 3988 16 services service NNS cord-010092-uftc8inx 3988 17 for for IN cord-010092-uftc8inx 3988 18 KTPH KTPH NNP cord-010092-uftc8inx 3988 19 as as RB cord-010092-uftc8inx 3988 20 well well RB cord-010092-uftc8inx 3988 21 as as IN cord-010092-uftc8inx 3988 22 the the DT cord-010092-uftc8inx 3988 23 neighbouring neighbouring JJ cord-010092-uftc8inx 3988 24 Yishun Yishun NNP cord-010092-uftc8inx 3988 25 Community Community NNP cord-010092-uftc8inx 3988 26 Hospital Hospital NNP cord-010092-uftc8inx 3988 27 ( ( -LRB- cord-010092-uftc8inx 3988 28 YCH YCH NNP cord-010092-uftc8inx 3988 29 ) ) -RRB- cord-010092-uftc8inx 3988 30 , , , cord-010092-uftc8inx 3988 31 one one CD cord-010092-uftc8inx 3988 32 of of IN cord-010092-uftc8inx 3988 33 the the DT cord-010092-uftc8inx 3988 34 largest large JJS cord-010092-uftc8inx 3988 35 community community NN cord-010092-uftc8inx 3988 36 hospitals hospital NNS cord-010092-uftc8inx 3988 37 in in IN cord-010092-uftc8inx 3988 38 Singapore Singapore NNP cord-010092-uftc8inx 3988 39 providing provide VBG cord-010092-uftc8inx 3988 40 intermediate intermediate JJ cord-010092-uftc8inx 3988 41 care care NN cord-010092-uftc8inx 3988 42 for for IN cord-010092-uftc8inx 3988 43 recuperating recuperate VBG cord-010092-uftc8inx 3988 44 patients patient NNS cord-010092-uftc8inx 3988 45 including include VBG cord-010092-uftc8inx 3988 46 rehabilitative rehabilitative JJ cord-010092-uftc8inx 3988 47 services service NNS cord-010092-uftc8inx 3988 48 . . . cord-010092-uftc8inx 3989 1 The the DT cord-010092-uftc8inx 3989 2 process process NN cord-010092-uftc8inx 3989 3 of of IN cord-010092-uftc8inx 3989 4 ordering order VBG cord-010092-uftc8inx 3989 5 transfusion transfusion NN cord-010092-uftc8inx 3989 6 - - HYPH cord-010092-uftc8inx 3989 7 related relate VBN cord-010092-uftc8inx 3989 8 test test NN cord-010092-uftc8inx 3989 9 requests request NNS cord-010092-uftc8inx 3989 10 in in IN cord-010092-uftc8inx 3989 11 both both DT cord-010092-uftc8inx 3989 12 hospitals hospital NNS cord-010092-uftc8inx 3989 13 is be VBZ cord-010092-uftc8inx 3989 14 through through IN cord-010092-uftc8inx 3989 15 printed print VBN cord-010092-uftc8inx 3989 16 forms form NNS cord-010092-uftc8inx 3989 17 . . . cord-010092-uftc8inx 3990 1 Aims aim VBZ cord-010092-uftc8inx 3990 2 : : : cord-010092-uftc8inx 3991 1 In in IN cord-010092-uftc8inx 3991 2 line line NN cord-010092-uftc8inx 3991 3 with with IN cord-010092-uftc8inx 3991 4 the the DT cord-010092-uftc8inx 3991 5 hospital hospital NN cord-010092-uftc8inx 3991 6 directive directive NN cord-010092-uftc8inx 3991 7 to to TO cord-010092-uftc8inx 3991 8 move move VB cord-010092-uftc8inx 3991 9 towards towards IN cord-010092-uftc8inx 3991 10 electronic electronic JJ cord-010092-uftc8inx 3991 11 patient patient NN cord-010092-uftc8inx 3991 12 management management NN cord-010092-uftc8inx 3991 13 , , , cord-010092-uftc8inx 3991 14 the the DT cord-010092-uftc8inx 3991 15 KTPH KTPH NNP cord-010092-uftc8inx 3991 16 Blood Blood NNP cord-010092-uftc8inx 3991 17 Bank Bank NNP cord-010092-uftc8inx 3991 18 intended intend VBD cord-010092-uftc8inx 3991 19 to to TO cord-010092-uftc8inx 3991 20 implement implement VB cord-010092-uftc8inx 3991 21 an an DT cord-010092-uftc8inx 3991 22 electronic electronic JJ cord-010092-uftc8inx 3991 23 Type type NN cord-010092-uftc8inx 3991 24 and and CC cord-010092-uftc8inx 3991 25 Screen screen NN cord-010092-uftc8inx 3991 26 ( ( -LRB- cord-010092-uftc8inx 3991 27 e e NN cord-010092-uftc8inx 3991 28 - - NN cord-010092-uftc8inx 3991 29 T&S t&s NN cord-010092-uftc8inx 3991 30 ) ) -RRB- cord-010092-uftc8inx 3991 31 system system NN cord-010092-uftc8inx 3991 32 . . . cord-010092-uftc8inx 3992 1 The the DT cord-010092-uftc8inx 3992 2 goal goal NN cord-010092-uftc8inx 3992 3 of of IN cord-010092-uftc8inx 3992 4 the the DT cord-010092-uftc8inx 3992 5 project project NN cord-010092-uftc8inx 3992 6 is be VBZ cord-010092-uftc8inx 3992 7 to to TO cord-010092-uftc8inx 3992 8 ensure ensure VB cord-010092-uftc8inx 3992 9 zero zero CD cord-010092-uftc8inx 3992 10 patient patient NN cord-010092-uftc8inx 3992 11 identification identification NN cord-010092-uftc8inx 3992 12 errors error NNS cord-010092-uftc8inx 3992 13 and and CC cord-010092-uftc8inx 3992 14 maintain maintain VB cord-010092-uftc8inx 3992 15 full full JJ cord-010092-uftc8inx 3992 16 traceability traceability NN cord-010092-uftc8inx 3992 17 and and CC cord-010092-uftc8inx 3992 18 accountability accountability NN cord-010092-uftc8inx 3992 19 for for IN cord-010092-uftc8inx 3992 20 the the DT cord-010092-uftc8inx 3992 21 blood blood NN cord-010092-uftc8inx 3992 22 collection collection NN cord-010092-uftc8inx 3992 23 process process NN cord-010092-uftc8inx 3992 24 in in IN cord-010092-uftc8inx 3992 25 all all DT cord-010092-uftc8inx 3992 26 transfusion transfusion NN cord-010092-uftc8inx 3992 27 - - HYPH cord-010092-uftc8inx 3992 28 related relate VBN cord-010092-uftc8inx 3992 29 testing testing NN cord-010092-uftc8inx 3992 30 . . . cord-010092-uftc8inx 3993 1 Another another DT cord-010092-uftc8inx 3993 2 aim aim NN cord-010092-uftc8inx 3993 3 of of IN cord-010092-uftc8inx 3993 4 the the DT cord-010092-uftc8inx 3993 5 system system NN cord-010092-uftc8inx 3993 6 is be VBZ cord-010092-uftc8inx 3993 7 to to TO cord-010092-uftc8inx 3993 8 reduce reduce VB cord-010092-uftc8inx 3993 9 repeated repeat VBN cord-010092-uftc8inx 3993 10 venepunctures venepuncture NNS cord-010092-uftc8inx 3993 11 when when WRB cord-010092-uftc8inx 3993 12 specimens specimen NNS cord-010092-uftc8inx 3993 13 are be VBP cord-010092-uftc8inx 3993 14 rejected reject VBN cord-010092-uftc8inx 3993 15 due due IN cord-010092-uftc8inx 3993 16 to to IN cord-010092-uftc8inx 3993 17 missing miss VBG cord-010092-uftc8inx 3993 18 essential essential JJ cord-010092-uftc8inx 3993 19 patient patient JJ cord-010092-uftc8inx 3993 20 information information NN cord-010092-uftc8inx 3993 21 on on IN cord-010092-uftc8inx 3993 22 the the DT cord-010092-uftc8inx 3993 23 printed print VBN cord-010092-uftc8inx 3993 24 forms form NNS cord-010092-uftc8inx 3993 25 by by IN cord-010092-uftc8inx 3993 26 implementing implement VBG cord-010092-uftc8inx 3993 27 mandatory mandatory JJ cord-010092-uftc8inx 3993 28 fields field NNS cord-010092-uftc8inx 3993 29 in in IN cord-010092-uftc8inx 3993 30 the the DT cord-010092-uftc8inx 3993 31 e e NN cord-010092-uftc8inx 3993 32 - - NN cord-010092-uftc8inx 3993 33 T&S t&s JJ cord-010092-uftc8inx 3993 34 form form NN cord-010092-uftc8inx 3993 35 . . . cord-010092-uftc8inx 3994 1 Methods method NNS cord-010092-uftc8inx 3994 2 : : : cord-010092-uftc8inx 3995 1 The the DT cord-010092-uftc8inx 3995 2 e e NN cord-010092-uftc8inx 3995 3 - - NN cord-010092-uftc8inx 3995 4 T&S T&S NNP cord-010092-uftc8inx 3995 5 was be VBD cord-010092-uftc8inx 3995 6 implemented implement VBN cord-010092-uftc8inx 3995 7 in in IN cord-010092-uftc8inx 3995 8 phases phase NNS cord-010092-uftc8inx 3995 9 . . . cord-010092-uftc8inx 3996 1 Phase phase NN cord-010092-uftc8inx 3996 2 1 1 CD cord-010092-uftc8inx 3996 3 : : : cord-010092-uftc8inx 3996 4 an an DT cord-010092-uftc8inx 3996 5 online online JJ cord-010092-uftc8inx 3996 6 version version NN cord-010092-uftc8inx 3996 7 of of IN cord-010092-uftc8inx 3996 8 the the DT cord-010092-uftc8inx 3996 9 printed print VBN cord-010092-uftc8inx 3996 10 form form NN cord-010092-uftc8inx 3996 11 was be VBD cord-010092-uftc8inx 3996 12 signed sign VBN cord-010092-uftc8inx 3996 13 electronically electronically RB cord-010092-uftc8inx 3996 14 by by IN cord-010092-uftc8inx 3996 15 the the DT cord-010092-uftc8inx 3996 16 ordering order VBG cord-010092-uftc8inx 3996 17 doctor doctor NN cord-010092-uftc8inx 3996 18 and and CC cord-010092-uftc8inx 3996 19 a a DT cord-010092-uftc8inx 3996 20 witness witness NN cord-010092-uftc8inx 3996 21 within within IN cord-010092-uftc8inx 3996 22 the the DT cord-010092-uftc8inx 3996 23 electronic electronic JJ cord-010092-uftc8inx 3996 24 medical medical JJ cord-010092-uftc8inx 3996 25 record record NN cord-010092-uftc8inx 3996 26 system system NN cord-010092-uftc8inx 3996 27 , , , cord-010092-uftc8inx 3997 1 Sunrise Sunrise NNP cord-010092-uftc8inx 3997 2 Clinical Clinical NNP cord-010092-uftc8inx 3997 3 Manager Manager NNP cord-010092-uftc8inx 3997 4 ( ( -LRB- cord-010092-uftc8inx 3997 5 SCM SCM NNP cord-010092-uftc8inx 3997 6 ) ) -RRB- cord-010092-uftc8inx 3997 7 system system NN cord-010092-uftc8inx 3997 8 with with IN cord-010092-uftc8inx 3997 9 the the DT cord-010092-uftc8inx 3997 10 doctor doctor NN cord-010092-uftc8inx 3997 11 counter counter NN cord-010092-uftc8inx 3997 12 - - NN cord-010092-uftc8inx 3997 13 checking checking NN cord-010092-uftc8inx 3997 14 by by IN cord-010092-uftc8inx 3997 15 signing sign VBG cord-010092-uftc8inx 3997 16 on on IN cord-010092-uftc8inx 3997 17 the the DT cord-010092-uftc8inx 3997 18 specimen specimen JJ cord-010092-uftc8inx 3997 19 label label NN cord-010092-uftc8inx 3997 20 to to TO cord-010092-uftc8inx 3997 21 ensure ensure VB cord-010092-uftc8inx 3997 22 correct correct JJ cord-010092-uftc8inx 3997 23 patient patient JJ cord-010092-uftc8inx 3997 24 identification identification NN cord-010092-uftc8inx 3997 25 . . . cord-010092-uftc8inx 3998 1 Phase phase NN cord-010092-uftc8inx 3998 2 2 2 CD cord-010092-uftc8inx 3998 3 : : : cord-010092-uftc8inx 3998 4 the the DT cord-010092-uftc8inx 3998 5 ordering order VBG cord-010092-uftc8inx 3998 6 doctor doctor NN cord-010092-uftc8inx 3998 7 is be VBZ cord-010092-uftc8inx 3998 8 not not RB cord-010092-uftc8inx 3998 9 required require VBN cord-010092-uftc8inx 3998 10 to to TO cord-010092-uftc8inx 3998 11 sign sign VB cord-010092-uftc8inx 3998 12 on on IN cord-010092-uftc8inx 3998 13 the the DT cord-010092-uftc8inx 3998 14 specimen specimen JJ cord-010092-uftc8inx 3998 15 label label NN cord-010092-uftc8inx 3998 16 since since IN cord-010092-uftc8inx 3998 17 fingerprint fingerprint NN cord-010092-uftc8inx 3998 18 biometrics biometric NNS cord-010092-uftc8inx 3998 19 are be VBP cord-010092-uftc8inx 3998 20 required require VBN cord-010092-uftc8inx 3998 21 for for IN cord-010092-uftc8inx 3998 22 the the DT cord-010092-uftc8inx 3998 23 electronic electronic JJ cord-010092-uftc8inx 3998 24 signin signin NNS cord-010092-uftc8inx 3998 25 . . . cord-010092-uftc8inx 3999 1 Phase phase NN cord-010092-uftc8inx 3999 2 3 3 CD cord-010092-uftc8inx 3999 3 : : : cord-010092-uftc8inx 3999 4 elimination elimination NN cord-010092-uftc8inx 3999 5 of of IN cord-010092-uftc8inx 3999 6 the the DT cord-010092-uftc8inx 3999 7 witness witness NN cord-010092-uftc8inx 3999 8 step step NN cord-010092-uftc8inx 3999 9 for for IN cord-010092-uftc8inx 3999 10 blood blood NN cord-010092-uftc8inx 3999 11 collection collection NN cord-010092-uftc8inx 3999 12 . . . cord-010092-uftc8inx 4000 1 Specimen specimen JJ cord-010092-uftc8inx 4000 2 collection collection NN cord-010092-uftc8inx 4000 3 and and CC cord-010092-uftc8inx 4000 4 rejection rejection NN cord-010092-uftc8inx 4000 5 data datum NNS cord-010092-uftc8inx 4000 6 from from IN cord-010092-uftc8inx 4000 7 2016 2016 CD cord-010092-uftc8inx 4000 8 to to IN cord-010092-uftc8inx 4000 9 2018 2018 CD cord-010092-uftc8inx 4000 10 was be VBD cord-010092-uftc8inx 4000 11 analysed analyse VBN cord-010092-uftc8inx 4000 12 . . . cord-010092-uftc8inx 4001 1 Specimen specimen JJ cord-010092-uftc8inx 4001 2 rejection rejection NN cord-010092-uftc8inx 4001 3 rate rate NN cord-010092-uftc8inx 4001 4 was be VBD cord-010092-uftc8inx 4001 5 presented present VBN cord-010092-uftc8inx 4001 6 as as IN cord-010092-uftc8inx 4001 7 percentage percentage NN cord-010092-uftc8inx 4001 8 of of IN cord-010092-uftc8inx 4001 9 rejected reject VBN cord-010092-uftc8inx 4001 10 specimens specimen NNS cord-010092-uftc8inx 4001 11 ( ( -LRB- cord-010092-uftc8inx 4001 12 mislabelled mislabelle VBN cord-010092-uftc8inx 4001 13 , , , cord-010092-uftc8inx 4001 14 unlabelled unlabelled JJ cord-010092-uftc8inx 4001 15 and and CC cord-010092-uftc8inx 4001 16 clerical clerical JJ cord-010092-uftc8inx 4001 17 errors error NNS cord-010092-uftc8inx 4001 18 ) ) -RRB- cord-010092-uftc8inx 4001 19 over over IN cord-010092-uftc8inx 4001 20 total total JJ cord-010092-uftc8inx 4001 21 specimen specimen JJ cord-010092-uftc8inx 4001 22 count count NN cord-010092-uftc8inx 4001 23 for for IN cord-010092-uftc8inx 4001 24 each each DT cord-010092-uftc8inx 4001 25 month month NN cord-010092-uftc8inx 4001 26 . . . cord-010092-uftc8inx 4002 1 Results result NNS cord-010092-uftc8inx 4002 2 : : : cord-010092-uftc8inx 4003 1 Between between IN cord-010092-uftc8inx 4003 2 January January NNP cord-010092-uftc8inx 4003 3 2016 2016 CD cord-010092-uftc8inx 4003 4 and and CC cord-010092-uftc8inx 4003 5 March March NNP cord-010092-uftc8inx 4003 6 2017 2017 CD cord-010092-uftc8inx 4003 7 , , , cord-010092-uftc8inx 4003 8 before before IN cord-010092-uftc8inx 4003 9 the the DT cord-010092-uftc8inx 4003 10 implementation implementation NN cord-010092-uftc8inx 4003 11 of of IN cord-010092-uftc8inx 4003 12 the the DT cord-010092-uftc8inx 4003 13 e e NN cord-010092-uftc8inx 4003 14 - - NN cord-010092-uftc8inx 4003 15 T&S T&S NNP cord-010092-uftc8inx 4003 16 phase phase NN cord-010092-uftc8inx 4003 17 1 1 CD cord-010092-uftc8inx 4003 18 , , , cord-010092-uftc8inx 4003 19 the the DT cord-010092-uftc8inx 4003 20 average average JJ cord-010092-uftc8inx 4003 21 rejection rejection NN cord-010092-uftc8inx 4003 22 rate rate NN cord-010092-uftc8inx 4003 23 for for IN cord-010092-uftc8inx 4003 24 blood blood NN cord-010092-uftc8inx 4003 25 bank bank NN cord-010092-uftc8inx 4003 26 specimens specimen NNS cord-010092-uftc8inx 4003 27 was be VBD cord-010092-uftc8inx 4003 28 0.16 0.16 CD cord-010092-uftc8inx 4003 29 % % NN cord-010092-uftc8inx 4003 30 and and CC cord-010092-uftc8inx 4003 31 1.14 1.14 CD cord-010092-uftc8inx 4003 32 % % NN cord-010092-uftc8inx 4003 33 for for IN cord-010092-uftc8inx 4003 34 identification identification NN cord-010092-uftc8inx 4003 35 and and CC cord-010092-uftc8inx 4003 36 clerical clerical JJ cord-010092-uftc8inx 4003 37 errors error NNS cord-010092-uftc8inx 4003 38 respectively respectively RB cord-010092-uftc8inx 4003 39 . . . cord-010092-uftc8inx 4004 1 During during IN cord-010092-uftc8inx 4004 2 phases phase NNS cord-010092-uftc8inx 4004 3 1 1 CD cord-010092-uftc8inx 4004 4 and and CC cord-010092-uftc8inx 4004 5 2 2 CD cord-010092-uftc8inx 4004 6 of of IN cord-010092-uftc8inx 4004 7 implementation implementation NN cord-010092-uftc8inx 4004 8 , , , cord-010092-uftc8inx 4004 9 rejection rejection NN cord-010092-uftc8inx 4004 10 rate rate NN cord-010092-uftc8inx 4004 11 increased increase VBD cord-010092-uftc8inx 4004 12 due due IN cord-010092-uftc8inx 4004 13 to to IN cord-010092-uftc8inx 4004 14 unfamiliarity unfamiliarity NN cord-010092-uftc8inx 4004 15 to to IN cord-010092-uftc8inx 4004 16 the the DT cord-010092-uftc8inx 4004 17 new new JJ cord-010092-uftc8inx 4004 18 work work NN cord-010092-uftc8inx 4004 19 processes process NNS cord-010092-uftc8inx 4004 20 . . . cord-010092-uftc8inx 4005 1 By by IN cord-010092-uftc8inx 4005 2 February February NNP cord-010092-uftc8inx 4005 3 2018 2018 CD cord-010092-uftc8inx 4005 4 , , , cord-010092-uftc8inx 4005 5 with with IN cord-010092-uftc8inx 4005 6 the the DT cord-010092-uftc8inx 4005 7 implementation implementation NN cord-010092-uftc8inx 4005 8 of of IN cord-010092-uftc8inx 4005 9 the the DT cord-010092-uftc8inx 4005 10 final final JJ cord-010092-uftc8inx 4005 11 phase phase NN cord-010092-uftc8inx 4005 12 of of IN cord-010092-uftc8inx 4005 13 the the DT cord-010092-uftc8inx 4005 14 e e NN cord-010092-uftc8inx 4005 15 - - NN cord-010092-uftc8inx 4005 16 T&S T&S NNP cord-010092-uftc8inx 4005 17 system system NN cord-010092-uftc8inx 4005 18 the the DT cord-010092-uftc8inx 4005 19 specimen specimen JJ cord-010092-uftc8inx 4005 20 rejection rejection NN cord-010092-uftc8inx 4005 21 rate rate NN cord-010092-uftc8inx 4005 22 was be VBD cord-010092-uftc8inx 4005 23 0.38 0.38 CD cord-010092-uftc8inx 4005 24 % % NN cord-010092-uftc8inx 4005 25 and and CC cord-010092-uftc8inx 4005 26 0.12 0.12 CD cord-010092-uftc8inx 4005 27 % % NN cord-010092-uftc8inx 4005 28 for for IN cord-010092-uftc8inx 4005 29 identification identification NN cord-010092-uftc8inx 4005 30 and and CC cord-010092-uftc8inx 4005 31 clerical clerical JJ cord-010092-uftc8inx 4005 32 errors error NNS cord-010092-uftc8inx 4005 33 respectively respectively RB cord-010092-uftc8inx 4005 34 . . . cord-010092-uftc8inx 4006 1 Rejected reject VBN cord-010092-uftc8inx 4006 2 specimens specimen NNS cord-010092-uftc8inx 4006 3 were be VBD cord-010092-uftc8inx 4006 4 mostly mostly RB cord-010092-uftc8inx 4006 5 from from IN cord-010092-uftc8inx 4006 6 the the DT cord-010092-uftc8inx 4006 7 few few JJ cord-010092-uftc8inx 4006 8 locations location NNS cord-010092-uftc8inx 4006 9 that that WDT cord-010092-uftc8inx 4006 10 had have VBD cord-010092-uftc8inx 4006 11 to to TO cord-010092-uftc8inx 4006 12 use use VB cord-010092-uftc8inx 4006 13 paper paper NN cord-010092-uftc8inx 4006 14 requisition requisition NN cord-010092-uftc8inx 4006 15 due due JJ cord-010092-uftc8inx 4006 16 to to TO cord-010092-uftc8inx 4006 17 workflow workflow VB cord-010092-uftc8inx 4006 18 or or CC cord-010092-uftc8inx 4006 19 infrastructure infrastructure NN cord-010092-uftc8inx 4006 20 limitations limitation NNS cord-010092-uftc8inx 4006 21 . . . cord-010092-uftc8inx 4007 1 Summary Summary NNP cord-010092-uftc8inx 4007 2 / / SYM cord-010092-uftc8inx 4007 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 4007 4 : : : cord-010092-uftc8inx 4008 1 The the DT cord-010092-uftc8inx 4008 2 e e NN cord-010092-uftc8inx 4008 3 - - JJ cord-010092-uftc8inx 4008 4 T&S T&S NNP cord-010092-uftc8inx 4008 5 system system NN cord-010092-uftc8inx 4008 6 was be VBD cord-010092-uftc8inx 4008 7 implemented implement VBN cord-010092-uftc8inx 4008 8 successfully successfully RB cord-010092-uftc8inx 4008 9 in in IN cord-010092-uftc8inx 4008 10 KTPH KTPH NNP cord-010092-uftc8inx 4008 11 . . . cord-010092-uftc8inx 4009 1 Full full JJ cord-010092-uftc8inx 4009 2 traceability traceability NN cord-010092-uftc8inx 4009 3 and and CC cord-010092-uftc8inx 4009 4 accountability accountability NN cord-010092-uftc8inx 4009 5 of of IN cord-010092-uftc8inx 4009 6 the the DT cord-010092-uftc8inx 4009 7 blood blood NN cord-010092-uftc8inx 4009 8 collection collection NN cord-010092-uftc8inx 4009 9 process process NN cord-010092-uftc8inx 4009 10 was be VBD cord-010092-uftc8inx 4009 11 maintained maintain VBN cord-010092-uftc8inx 4009 12 with with IN cord-010092-uftc8inx 4009 13 the the DT cord-010092-uftc8inx 4009 14 fully fully RB cord-010092-uftc8inx 4009 15 electronic electronic JJ cord-010092-uftc8inx 4009 16 system system NN cord-010092-uftc8inx 4009 17 . . . cord-010092-uftc8inx 4010 1 The the DT cord-010092-uftc8inx 4010 2 adoption adoption NN cord-010092-uftc8inx 4010 3 of of IN cord-010092-uftc8inx 4010 4 electronic electronic JJ cord-010092-uftc8inx 4010 5 documentation documentation NN cord-010092-uftc8inx 4010 6 has have VBZ cord-010092-uftc8inx 4010 7 also also RB cord-010092-uftc8inx 4010 8 reduced reduce VBN cord-010092-uftc8inx 4010 9 the the DT cord-010092-uftc8inx 4010 10 number number NN cord-010092-uftc8inx 4010 11 of of IN cord-010092-uftc8inx 4010 12 preventable preventable JJ cord-010092-uftc8inx 4010 13 repeated repeat VBN cord-010092-uftc8inx 4010 14 venepunctures venepuncture NNS cord-010092-uftc8inx 4010 15 that that WDT cord-010092-uftc8inx 4010 16 were be VBD cord-010092-uftc8inx 4010 17 due due JJ cord-010092-uftc8inx 4010 18 to to IN cord-010092-uftc8inx 4010 19 incomplete incomplete JJ cord-010092-uftc8inx 4010 20 order order NN cord-010092-uftc8inx 4010 21 information information NN cord-010092-uftc8inx 4010 22 on on IN cord-010092-uftc8inx 4010 23 the the DT cord-010092-uftc8inx 4010 24 printed print VBN cord-010092-uftc8inx 4010 25 forms form NNS cord-010092-uftc8inx 4010 26 . . . cord-010092-uftc8inx 4011 1 Future future JJ cord-010092-uftc8inx 4011 2 developments development NNS cord-010092-uftc8inx 4011 3 in in IN cord-010092-uftc8inx 4011 4 technology technology NN cord-010092-uftc8inx 4011 5 and and CC cord-010092-uftc8inx 4011 6 full full JJ cord-010092-uftc8inx 4011 7 implementation implementation NN cord-010092-uftc8inx 4011 8 of of IN cord-010092-uftc8inx 4011 9 e e NN cord-010092-uftc8inx 4011 10 - - JJ cord-010092-uftc8inx 4011 11 T&S t&s JJ cord-010092-uftc8inx 4011 12 system system NN cord-010092-uftc8inx 4011 13 in in IN cord-010092-uftc8inx 4011 14 all all DT cord-010092-uftc8inx 4011 15 hospital hospital NN cord-010092-uftc8inx 4011 16 locations location NNS cord-010092-uftc8inx 4011 17 may may MD cord-010092-uftc8inx 4011 18 make make VB cord-010092-uftc8inx 4011 19 zero zero CD cord-010092-uftc8inx 4011 20 patient patient NN cord-010092-uftc8inx 4011 21 identification identification NN cord-010092-uftc8inx 4011 22 error error NN cord-010092-uftc8inx 4011 23 achievable achievable JJ cord-010092-uftc8inx 4011 24 and and CC cord-010092-uftc8inx 4011 25 ensure ensure VB cord-010092-uftc8inx 4011 26 transfusion transfusion NN cord-010092-uftc8inx 4011 27 safety safety NN cord-010092-uftc8inx 4011 28 in in IN cord-010092-uftc8inx 4011 29 all all DT cord-010092-uftc8inx 4011 30 patients patient NNS cord-010092-uftc8inx 4011 31 in in IN cord-010092-uftc8inx 4011 32 the the DT cord-010092-uftc8inx 4011 33 near near JJ cord-010092-uftc8inx 4011 34 future future NN cord-010092-uftc8inx 4011 35 . . . cord-010092-uftc8inx 4012 1 Background background NN cord-010092-uftc8inx 4012 2 : : : cord-010092-uftc8inx 4013 1 Blood blood NN cord-010092-uftc8inx 4013 2 component component NN cord-010092-uftc8inx 4013 3 administration administration NN cord-010092-uftc8inx 4013 4 represents represent VBZ cord-010092-uftc8inx 4013 5 a a DT cord-010092-uftc8inx 4013 6 critical critical JJ cord-010092-uftc8inx 4013 7 phase phase NN cord-010092-uftc8inx 4013 8 due due IN cord-010092-uftc8inx 4013 9 to to IN cord-010092-uftc8inx 4013 10 the the DT cord-010092-uftc8inx 4013 11 possible possible JJ cord-010092-uftc8inx 4013 12 occurrence occurrence NN cord-010092-uftc8inx 4013 13 of of IN cord-010092-uftc8inx 4013 14 errors error NNS cord-010092-uftc8inx 4013 15 during during IN cord-010092-uftc8inx 4013 16 the the DT cord-010092-uftc8inx 4013 17 different different JJ cord-010092-uftc8inx 4013 18 steps step NNS cord-010092-uftc8inx 4013 19 from from IN cord-010092-uftc8inx 4013 20 the the DT cord-010092-uftc8inx 4013 21 identification identification NN cord-010092-uftc8inx 4013 22 of of IN cord-010092-uftc8inx 4013 23 the the DT cord-010092-uftc8inx 4013 24 patient patient NN cord-010092-uftc8inx 4013 25 to to IN cord-010092-uftc8inx 4013 26 the the DT cord-010092-uftc8inx 4013 27 infusion infusion NN cord-010092-uftc8inx 4013 28 of of IN cord-010092-uftc8inx 4013 29 the the DT cord-010092-uftc8inx 4013 30 product product NN cord-010092-uftc8inx 4013 31 . . . cord-010092-uftc8inx 4014 1 Error error NN cord-010092-uftc8inx 4014 2 occurrence occurrence NN cord-010092-uftc8inx 4014 3 can can MD cord-010092-uftc8inx 4014 4 be be VB cord-010092-uftc8inx 4014 5 reduced reduce VBN cord-010092-uftc8inx 4014 6 by by IN cord-010092-uftc8inx 4014 7 the the DT cord-010092-uftc8inx 4014 8 implementation implementation NN cord-010092-uftc8inx 4014 9 of of IN cord-010092-uftc8inx 4014 10 validated validate VBN cord-010092-uftc8inx 4014 11 information information NN cord-010092-uftc8inx 4014 12 systems system NNS cord-010092-uftc8inx 4014 13 . . . cord-010092-uftc8inx 4015 1 We -PRON- PRP cord-010092-uftc8inx 4015 2 tested test VBD cord-010092-uftc8inx 4015 3 the the DT cord-010092-uftc8inx 4015 4 SCWeb SCWeb NNP cord-010092-uftc8inx 4015 5 â â CD cord-010092-uftc8inx 4015 6 System system NN cord-010092-uftc8inx 4015 7 at at IN cord-010092-uftc8inx 4015 8 the the DT cord-010092-uftc8inx 4015 9 bedside bedside NN cord-010092-uftc8inx 4015 10 in in IN cord-010092-uftc8inx 4015 11 a a DT cord-010092-uftc8inx 4015 12 transfusion transfusion NN cord-010092-uftc8inx 4015 13 outpatient outpatient NN cord-010092-uftc8inx 4015 14 clinic clinic NN cord-010092-uftc8inx 4015 15 . . . cord-010092-uftc8inx 4016 1 Aims aim VBZ cord-010092-uftc8inx 4016 2 : : : cord-010092-uftc8inx 4017 1 The the DT cord-010092-uftc8inx 4017 2 aim aim NN cord-010092-uftc8inx 4017 3 of of IN cord-010092-uftc8inx 4017 4 the the DT cord-010092-uftc8inx 4017 5 study study NN cord-010092-uftc8inx 4017 6 is be VBZ cord-010092-uftc8inx 4017 7 to to TO cord-010092-uftc8inx 4017 8 validate validate VB cord-010092-uftc8inx 4017 9 a a DT cord-010092-uftc8inx 4017 10 system system NN cord-010092-uftc8inx 4017 11 designed design VBN cord-010092-uftc8inx 4017 12 to to TO cord-010092-uftc8inx 4017 13 assist assist VB cord-010092-uftc8inx 4017 14 and and CC cord-010092-uftc8inx 4017 15 to to TO cord-010092-uftc8inx 4017 16 control control VB cord-010092-uftc8inx 4017 17 blood blood NN cord-010092-uftc8inx 4017 18 administration administration NN cord-010092-uftc8inx 4017 19 step step NN cord-010092-uftc8inx 4017 20 by by IN cord-010092-uftc8inx 4017 21 step step NN cord-010092-uftc8inx 4017 22 using use VBG cord-010092-uftc8inx 4017 23 electronic electronic JJ cord-010092-uftc8inx 4017 24 devices device NNS cord-010092-uftc8inx 4017 25 to to TO cord-010092-uftc8inx 4017 26 ensure ensure VB cord-010092-uftc8inx 4017 27 traceability traceability NN cord-010092-uftc8inx 4017 28 and and CC cord-010092-uftc8inx 4017 29 documentation documentation NN cord-010092-uftc8inx 4017 30 of of IN cord-010092-uftc8inx 4017 31 the the DT cord-010092-uftc8inx 4017 32 process process NN cord-010092-uftc8inx 4017 33 Methods method NNS cord-010092-uftc8inx 4017 34 : : : cord-010092-uftc8inx 4018 1 The the DT cord-010092-uftc8inx 4018 2 SCWeb SCWeb NNP cord-010092-uftc8inx 4018 3 â â NN cord-010092-uftc8inx 4018 4 System System NNP cord-010092-uftc8inx 4018 5 is be VBZ cord-010092-uftc8inx 4018 6 based base VBN cord-010092-uftc8inx 4018 7 on on IN cord-010092-uftc8inx 4018 8 IT it PRP cord-010092-uftc8inx 4018 9 monitored monitor VBD cord-010092-uftc8inx 4018 10 checklists checklist NNS cord-010092-uftc8inx 4018 11 which which WDT cord-010092-uftc8inx 4018 12 guide guide VBP cord-010092-uftc8inx 4018 13 the the DT cord-010092-uftc8inx 4018 14 personnel personnel NNS cord-010092-uftc8inx 4018 15 to to TO cord-010092-uftc8inx 4018 16 follow follow VB cord-010092-uftc8inx 4018 17 the the DT cord-010092-uftc8inx 4018 18 procedure procedure NN cord-010092-uftc8inx 4018 19 , , , cord-010092-uftc8inx 4018 20 according accord VBG cord-010092-uftc8inx 4018 21 to to IN cord-010092-uftc8inx 4018 22 best good JJS cord-010092-uftc8inx 4018 23 practices practice NNS cord-010092-uftc8inx 4018 24 ; ; : cord-010092-uftc8inx 4018 25 the the DT cord-010092-uftc8inx 4018 26 system system NN cord-010092-uftc8inx 4018 27 must must MD cord-010092-uftc8inx 4018 28 initially initially RB cord-010092-uftc8inx 4018 29 be be VB cord-010092-uftc8inx 4018 30 activated activate VBN cord-010092-uftc8inx 4018 31 by by IN cord-010092-uftc8inx 4018 32 the the DT cord-010092-uftc8inx 4018 33 operator operator NN cord-010092-uftc8inx 4018 34 which which WDT cord-010092-uftc8inx 4018 35 is be VBZ cord-010092-uftc8inx 4018 36 recognized recognize VBN cord-010092-uftc8inx 4018 37 by by IN cord-010092-uftc8inx 4018 38 an an DT cord-010092-uftc8inx 4018 39 auto auto NN cord-010092-uftc8inx 4018 40 - - HYPH cord-010092-uftc8inx 4018 41 signing signing NN cord-010092-uftc8inx 4018 42 system system NN cord-010092-uftc8inx 4018 43 based base VBN cord-010092-uftc8inx 4018 44 on on IN cord-010092-uftc8inx 4018 45 Bluetooth Bluetooth NNP cord-010092-uftc8inx 4018 46 Low Low NNP cord-010092-uftc8inx 4018 47 Energy Energy NNP cord-010092-uftc8inx 4018 48 which which WDT cord-010092-uftc8inx 4018 49 avoids avoid VBZ cord-010092-uftc8inx 4018 50 the the DT cord-010092-uftc8inx 4018 51 operator operator NN cord-010092-uftc8inx 4018 52 having have VBG cord-010092-uftc8inx 4018 53 to to TO cord-010092-uftc8inx 4018 54 identify identify VB cord-010092-uftc8inx 4018 55 himself -PRON- PRP cord-010092-uftc8inx 4018 56 / / SYM cord-010092-uftc8inx 4018 57 herself -PRON- PRP cord-010092-uftc8inx 4018 58 beforehand beforehand RB cord-010092-uftc8inx 4018 59 . . . cord-010092-uftc8inx 4019 1 Appropriate appropriate JJ cord-010092-uftc8inx 4019 2 privacy privacy NN cord-010092-uftc8inx 4019 3 protection protection NN cord-010092-uftc8inx 4019 4 is be VBZ cord-010092-uftc8inx 4019 5 provided provide VBN cord-010092-uftc8inx 4019 6 . . . cord-010092-uftc8inx 4020 1 Thereafter thereafter RB cord-010092-uftc8inx 4020 2 the the DT cord-010092-uftc8inx 4020 3 system system NN cord-010092-uftc8inx 4020 4 takes take VBZ cord-010092-uftc8inx 4020 5 up up RP cord-010092-uftc8inx 4020 6 the the DT cord-010092-uftc8inx 4020 7 task task NN cord-010092-uftc8inx 4020 8 to to TO cord-010092-uftc8inx 4020 9 give give VB cord-010092-uftc8inx 4020 10 instructions instruction NNS cord-010092-uftc8inx 4020 11 and and CC cord-010092-uftc8inx 4020 12 to to TO cord-010092-uftc8inx 4020 13 verify verify VB cord-010092-uftc8inx 4020 14 the the DT cord-010092-uftc8inx 4020 15 adherence adherence NN cord-010092-uftc8inx 4020 16 , , , cord-010092-uftc8inx 4020 17 by by IN cord-010092-uftc8inx 4020 18 asking ask VBG cord-010092-uftc8inx 4020 19 an an DT cord-010092-uftc8inx 4020 20 active active JJ cord-010092-uftc8inx 4020 21 confirmation confirmation NN cord-010092-uftc8inx 4020 22 of of IN cord-010092-uftc8inx 4020 23 the the DT cord-010092-uftc8inx 4020 24 proper proper JJ cord-010092-uftc8inx 4020 25 fulfillment fulfillment NN cord-010092-uftc8inx 4020 26 of of IN cord-010092-uftc8inx 4020 27 the the DT cord-010092-uftc8inx 4020 28 activities activity NNS cord-010092-uftc8inx 4020 29 ; ; : cord-010092-uftc8inx 4020 30 a a DT cord-010092-uftc8inx 4020 31 continuous continuous JJ cord-010092-uftc8inx 4020 32 registration registration NN cord-010092-uftc8inx 4020 33 and and CC cord-010092-uftc8inx 4020 34 documentation documentation NN cord-010092-uftc8inx 4020 35 is be VBZ cord-010092-uftc8inx 4020 36 made make VBN cord-010092-uftc8inx 4020 37 by by IN cord-010092-uftc8inx 4020 38 the the DT cord-010092-uftc8inx 4020 39 system system NN cord-010092-uftc8inx 4020 40 . . . cord-010092-uftc8inx 4021 1 Standards standard NNS cord-010092-uftc8inx 4021 2 and and CC cord-010092-uftc8inx 4021 3 specifications specification NNS cord-010092-uftc8inx 4021 4 for for IN cord-010092-uftc8inx 4021 5 each each DT cord-010092-uftc8inx 4021 6 step step NN cord-010092-uftc8inx 4021 7 of of IN cord-010092-uftc8inx 4021 8 the the DT cord-010092-uftc8inx 4021 9 procedure procedure NN cord-010092-uftc8inx 4021 10 have have VBP cord-010092-uftc8inx 4021 11 been be VBN cord-010092-uftc8inx 4021 12 configured configure VBN cord-010092-uftc8inx 4021 13 on on IN cord-010092-uftc8inx 4021 14 SCWeb SCWeb NNP cord-010092-uftc8inx 4021 15 â â CD cord-010092-uftc8inx 4021 16 System system NN cord-010092-uftc8inx 4021 17 to to TO cord-010092-uftc8inx 4021 18 track track VB cord-010092-uftc8inx 4021 19 in in IN cord-010092-uftc8inx 4021 20 detail detail NN cord-010092-uftc8inx 4021 21 operator operator NN cord-010092-uftc8inx 4021 22 and and CC cord-010092-uftc8inx 4021 23 patient patient JJ cord-010092-uftc8inx 4021 24 identification identification NN cord-010092-uftc8inx 4021 25 , , , cord-010092-uftc8inx 4021 26 presence presence NN cord-010092-uftc8inx 4021 27 of of IN cord-010092-uftc8inx 4021 28 informed informed JJ cord-010092-uftc8inx 4021 29 consent consent NN cord-010092-uftc8inx 4021 30 to to IN cord-010092-uftc8inx 4021 31 transfusion transfusion NN cord-010092-uftc8inx 4021 32 , , , cord-010092-uftc8inx 4021 33 blood blood NN cord-010092-uftc8inx 4021 34 pressure pressure NN cord-010092-uftc8inx 4021 35 , , , cord-010092-uftc8inx 4021 36 pulse pulse NN cord-010092-uftc8inx 4021 37 and and CC cord-010092-uftc8inx 4021 38 temperature temperature NN cord-010092-uftc8inx 4021 39 recording recording NN cord-010092-uftc8inx 4021 40 , , , cord-010092-uftc8inx 4021 41 vein vein NN cord-010092-uftc8inx 4021 42 access access NN cord-010092-uftc8inx 4021 43 , , , cord-010092-uftc8inx 4021 44 verification verification NN cord-010092-uftc8inx 4021 45 of of IN cord-010092-uftc8inx 4021 46 the the DT cord-010092-uftc8inx 4021 47 blood blood NN cord-010092-uftc8inx 4021 48 unit unit NN cord-010092-uftc8inx 4021 49 . . . cord-010092-uftc8inx 4022 1 An an DT cord-010092-uftc8inx 4022 2 alarm alarm NN cord-010092-uftc8inx 4022 3 has have VBZ cord-010092-uftc8inx 4022 4 been be VBN cord-010092-uftc8inx 4022 5 set set VBN cord-010092-uftc8inx 4022 6 after after IN cord-010092-uftc8inx 4022 7 15 15 CD cord-010092-uftc8inx 4022 8 min min NN cord-010092-uftc8inx 4022 9 , , , cord-010092-uftc8inx 4022 10 to to TO cord-010092-uftc8inx 4022 11 ensure ensure VB cord-010092-uftc8inx 4022 12 the the DT cord-010092-uftc8inx 4022 13 control control NN cord-010092-uftc8inx 4022 14 of of IN cord-010092-uftc8inx 4022 15 patient patient NN cord-010092-uftc8inx 4022 16 's 's POS cord-010092-uftc8inx 4022 17 conditions condition NNS cord-010092-uftc8inx 4022 18 . . . cord-010092-uftc8inx 4023 1 For for IN cord-010092-uftc8inx 4023 2 each each DT cord-010092-uftc8inx 4023 3 step step NN cord-010092-uftc8inx 4023 4 , , , cord-010092-uftc8inx 4023 5 an an DT cord-010092-uftc8inx 4023 6 active active JJ cord-010092-uftc8inx 4023 7 confirmation confirmation NN cord-010092-uftc8inx 4023 8 of of IN cord-010092-uftc8inx 4023 9 the the DT cord-010092-uftc8inx 4023 10 action action NN cord-010092-uftc8inx 4023 11 is be VBZ cord-010092-uftc8inx 4023 12 required require VBN cord-010092-uftc8inx 4023 13 and and CC cord-010092-uftc8inx 4023 14 nurse nurse NN cord-010092-uftc8inx 4023 15 and and CC cord-010092-uftc8inx 4023 16 doctor doctor VB cord-010092-uftc8inx 4023 17 direct direct JJ cord-010092-uftc8inx 4023 18 involvement involvement NN cord-010092-uftc8inx 4023 19 must must MD cord-010092-uftc8inx 4023 20 be be VB cord-010092-uftc8inx 4023 21 actively actively RB cord-010092-uftc8inx 4023 22 confirmed confirm VBN cord-010092-uftc8inx 4023 23 on on IN cord-010092-uftc8inx 4023 24 the the DT cord-010092-uftc8inx 4023 25 device device NN cord-010092-uftc8inx 4023 26 by by IN cord-010092-uftc8inx 4023 27 both both DT cord-010092-uftc8inx 4023 28 operators operator NNS cord-010092-uftc8inx 4023 29 . . . cord-010092-uftc8inx 4024 1 The the DT cord-010092-uftc8inx 4024 2 system system NN cord-010092-uftc8inx 4024 3 has have VBZ cord-010092-uftc8inx 4024 4 been be VBN cord-010092-uftc8inx 4024 5 tested test VBN cord-010092-uftc8inx 4024 6 at at IN cord-010092-uftc8inx 4024 7 the the DT cord-010092-uftc8inx 4024 8 bedside bedside NN cord-010092-uftc8inx 4024 9 on on IN cord-010092-uftc8inx 4024 10 30 30 CD cord-010092-uftc8inx 4024 11 patients patient NNS cord-010092-uftc8inx 4024 12 admitted admit VBN cord-010092-uftc8inx 4024 13 to to IN cord-010092-uftc8inx 4024 14 the the DT cord-010092-uftc8inx 4024 15 outpatient outpatient NN cord-010092-uftc8inx 4024 16 clinic clinic NN cord-010092-uftc8inx 4024 17 for for IN cord-010092-uftc8inx 4024 18 45 45 CD cord-010092-uftc8inx 4024 19 red red JJ cord-010092-uftc8inx 4024 20 cell cell NN cord-010092-uftc8inx 4024 21 concentrate concentrate NN cord-010092-uftc8inx 4024 22 transfusion transfusion NN cord-010092-uftc8inx 4024 23 ; ; : cord-010092-uftc8inx 4024 24 compliance compliance NN cord-010092-uftc8inx 4024 25 of of IN cord-010092-uftc8inx 4024 26 the the DT cord-010092-uftc8inx 4024 27 personnel personnel NNS cord-010092-uftc8inx 4024 28 and and CC cord-010092-uftc8inx 4024 29 organizational organizational JJ cord-010092-uftc8inx 4024 30 impact impact NN cord-010092-uftc8inx 4024 31 has have VBZ cord-010092-uftc8inx 4024 32 been be VBN cord-010092-uftc8inx 4024 33 recorded record VBN cord-010092-uftc8inx 4024 34 . . . cord-010092-uftc8inx 4025 1 Results result NNS cord-010092-uftc8inx 4025 2 : : : cord-010092-uftc8inx 4026 1 The the DT cord-010092-uftc8inx 4026 2 System System NNP cord-010092-uftc8inx 4026 3 required require VBD cord-010092-uftc8inx 4026 4 a a DT cord-010092-uftc8inx 4026 5 very very RB cord-010092-uftc8inx 4026 6 short short JJ cord-010092-uftc8inx 4026 7 training training NN cord-010092-uftc8inx 4026 8 : : : cord-010092-uftc8inx 4026 9 ease ease NN cord-010092-uftc8inx 4026 10 of of IN cord-010092-uftc8inx 4026 11 SCWeb SCWeb NNP cord-010092-uftc8inx 4026 12 â â CD cord-010092-uftc8inx 4026 13 system system NN cord-010092-uftc8inx 4026 14 allows allow VBZ cord-010092-uftc8inx 4026 15 its -PRON- PRP$ cord-010092-uftc8inx 4026 16 implementation implementation NN cord-010092-uftc8inx 4026 17 without without IN cord-010092-uftc8inx 4026 18 negative negative JJ cord-010092-uftc8inx 4026 19 impact impact NN cord-010092-uftc8inx 4026 20 on on IN cord-010092-uftc8inx 4026 21 organization organization NN cord-010092-uftc8inx 4026 22 of of IN cord-010092-uftc8inx 4026 23 transfusion transfusion NN cord-010092-uftc8inx 4026 24 outpatient outpatient NN cord-010092-uftc8inx 4026 25 clinic clinic NN cord-010092-uftc8inx 4026 26 and and CC cord-010092-uftc8inx 4026 27 without without IN cord-010092-uftc8inx 4026 28 difficulties difficulty NNS cord-010092-uftc8inx 4026 29 by by IN cord-010092-uftc8inx 4026 30 operators operator NNS cord-010092-uftc8inx 4026 31 ( ( -LRB- cord-010092-uftc8inx 4026 32 nurses nurse NNS cord-010092-uftc8inx 4026 33 and and CC cord-010092-uftc8inx 4026 34 doctors doctor NNS cord-010092-uftc8inx 4026 35 ) ) -RRB- cord-010092-uftc8inx 4026 36 , , , cord-010092-uftc8inx 4026 37 who who WP cord-010092-uftc8inx 4026 38 appreciated appreciate VBD cord-010092-uftc8inx 4026 39 the the DT cord-010092-uftc8inx 4026 40 help help NN cord-010092-uftc8inx 4026 41 given give VBN cord-010092-uftc8inx 4026 42 by by IN cord-010092-uftc8inx 4026 43 the the DT cord-010092-uftc8inx 4026 44 IT IT NNP cord-010092-uftc8inx 4026 45 check check NN cord-010092-uftc8inx 4026 46 system system NN cord-010092-uftc8inx 4026 47 . . . cord-010092-uftc8inx 4027 1 The the DT cord-010092-uftc8inx 4027 2 registration registration NN cord-010092-uftc8inx 4027 3 of of IN cord-010092-uftc8inx 4027 4 the the DT cord-010092-uftc8inx 4027 5 electronic electronic JJ cord-010092-uftc8inx 4027 6 check check NN cord-010092-uftc8inx 4027 7 list list NN cord-010092-uftc8inx 4027 8 offered offer VBD cord-010092-uftc8inx 4027 9 a a DT cord-010092-uftc8inx 4027 10 reliable reliable JJ cord-010092-uftc8inx 4027 11 tool tool NN cord-010092-uftc8inx 4027 12 for for IN cord-010092-uftc8inx 4027 13 the the DT cord-010092-uftc8inx 4027 14 traceability traceability NN cord-010092-uftc8inx 4027 15 of of IN cord-010092-uftc8inx 4027 16 the the DT cord-010092-uftc8inx 4027 17 transfusion transfusion NN cord-010092-uftc8inx 4027 18 procedure procedure NN cord-010092-uftc8inx 4027 19 , , , cord-010092-uftc8inx 4027 20 also also RB cord-010092-uftc8inx 4027 21 granting grant VBG cord-010092-uftc8inx 4027 22 a a DT cord-010092-uftc8inx 4027 23 paperless paperless NN cord-010092-uftc8inx 4027 24 and and CC cord-010092-uftc8inx 4027 25 timely timely RB cord-010092-uftc8inx 4027 26 available available JJ cord-010092-uftc8inx 4027 27 documentation documentation NN cord-010092-uftc8inx 4027 28 of of IN cord-010092-uftc8inx 4027 29 the the DT cord-010092-uftc8inx 4027 30 entire entire JJ cord-010092-uftc8inx 4027 31 process process NN cord-010092-uftc8inx 4027 32 through through IN cord-010092-uftc8inx 4027 33 a a DT cord-010092-uftc8inx 4027 34 registration registration NN cord-010092-uftc8inx 4027 35 in in IN cord-010092-uftc8inx 4027 36 electronic electronic JJ cord-010092-uftc8inx 4027 37 format format NN cord-010092-uftc8inx 4027 38 of of IN cord-010092-uftc8inx 4027 39 all all PDT cord-010092-uftc8inx 4027 40 the the DT cord-010092-uftc8inx 4027 41 operator operator NN cord-010092-uftc8inx 4027 42 's 's POS cord-010092-uftc8inx 4027 43 action action NN cord-010092-uftc8inx 4027 44 in in IN cord-010092-uftc8inx 4027 45 every every DT cord-010092-uftc8inx 4027 46 single single JJ cord-010092-uftc8inx 4027 47 phase phase NN cord-010092-uftc8inx 4027 48 of of IN cord-010092-uftc8inx 4027 49 the the DT cord-010092-uftc8inx 4027 50 transfusion transfusion NN cord-010092-uftc8inx 4027 51 process process NN cord-010092-uftc8inx 4027 52 . . . cord-010092-uftc8inx 4028 1 When when WRB cord-010092-uftc8inx 4028 2 prescribed prescribe VBN cord-010092-uftc8inx 4028 3 , , , cord-010092-uftc8inx 4028 4 confirmation confirmation NN cord-010092-uftc8inx 4028 5 of of IN cord-010092-uftc8inx 4028 6 the the DT cord-010092-uftc8inx 4028 7 checklist checklist NN cord-010092-uftc8inx 4028 8 was be VBD cord-010092-uftc8inx 4028 9 only only RB cord-010092-uftc8inx 4028 10 possible possible JJ cord-010092-uftc8inx 4028 11 in in IN cord-010092-uftc8inx 4028 12 the the DT cord-010092-uftc8inx 4028 13 presence presence NN cord-010092-uftc8inx 4028 14 and and CC cord-010092-uftc8inx 4028 15 with with IN cord-010092-uftc8inx 4028 16 the the DT cord-010092-uftc8inx 4028 17 active active JJ cord-010092-uftc8inx 4028 18 confirmation confirmation NN cord-010092-uftc8inx 4028 19 of of IN cord-010092-uftc8inx 4028 20 two two CD cord-010092-uftc8inx 4028 21 operators operator NNS cord-010092-uftc8inx 4028 22 ( ( -LRB- cord-010092-uftc8inx 4028 23 doctor doctor NN cord-010092-uftc8inx 4028 24 and and CC cord-010092-uftc8inx 4028 25 nurse nurse NN cord-010092-uftc8inx 4028 26 ) ) -RRB- cord-010092-uftc8inx 4028 27 . . . cord-010092-uftc8inx 4029 1 Summary Summary NNP cord-010092-uftc8inx 4029 2 / / SYM cord-010092-uftc8inx 4029 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 4029 4 : : : cord-010092-uftc8inx 4030 1 The the DT cord-010092-uftc8inx 4030 2 SCWeb SCWeb NNP cord-010092-uftc8inx 4030 3 â â CD cord-010092-uftc8inx 4030 4 system system NN cord-010092-uftc8inx 4030 5 is be VBZ cord-010092-uftc8inx 4030 6 useful useful JJ cord-010092-uftc8inx 4030 7 as as IN cord-010092-uftc8inx 4030 8 a a DT cord-010092-uftc8inx 4030 9 barrier barrier NN cord-010092-uftc8inx 4030 10 against against IN cord-010092-uftc8inx 4030 11 the the DT cord-010092-uftc8inx 4030 12 mismatch mismatch NN cord-010092-uftc8inx 4030 13 of of IN cord-010092-uftc8inx 4030 14 transfusion transfusion NN cord-010092-uftc8inx 4030 15 ( ( -LRB- cord-010092-uftc8inx 4030 16 preventive preventive JJ cord-010092-uftc8inx 4030 17 measure measure NN cord-010092-uftc8inx 4030 18 ) ) -RRB- cord-010092-uftc8inx 4030 19 , , , cord-010092-uftc8inx 4030 20 as as IN cord-010092-uftc8inx 4030 21 a a DT cord-010092-uftc8inx 4030 22 traceability traceability NN cord-010092-uftc8inx 4030 23 and and CC cord-010092-uftc8inx 4030 24 documentation documentation NN cord-010092-uftc8inx 4030 25 measure measure NN cord-010092-uftc8inx 4030 26 and and CC cord-010092-uftc8inx 4030 27 as as IN cord-010092-uftc8inx 4030 28 a a DT cord-010092-uftc8inx 4030 29 tool tool NN cord-010092-uftc8inx 4030 30 for for IN cord-010092-uftc8inx 4030 31 training training NN cord-010092-uftc8inx 4030 32 of of IN cord-010092-uftc8inx 4030 33 personnel personnel NNS cord-010092-uftc8inx 4030 34 in in IN cord-010092-uftc8inx 4030 35 blood blood NN cord-010092-uftc8inx 4030 36 transfusion transfusion NN cord-010092-uftc8inx 4030 37 administration administration NN cord-010092-uftc8inx 4030 38 ; ; : cord-010092-uftc8inx 4030 39 it -PRON- PRP cord-010092-uftc8inx 4030 40 avoids avoid VBZ cord-010092-uftc8inx 4030 41 paper paper NN cord-010092-uftc8inx 4030 42 registration registration NN cord-010092-uftc8inx 4030 43 during during IN cord-010092-uftc8inx 4030 44 the the DT cord-010092-uftc8inx 4030 45 transfusion transfusion NN cord-010092-uftc8inx 4030 46 process process NN cord-010092-uftc8inx 4030 47 , , , cord-010092-uftc8inx 4030 48 due due IN cord-010092-uftc8inx 4030 49 to to IN cord-010092-uftc8inx 4030 50 the the DT cord-010092-uftc8inx 4030 51 timely timely JJ cord-010092-uftc8inx 4030 52 registration registration NN cord-010092-uftc8inx 4030 53 of of IN cord-010092-uftc8inx 4030 54 the the DT cord-010092-uftc8inx 4030 55 activities activity NNS cord-010092-uftc8inx 4030 56 performed perform VBN cord-010092-uftc8inx 4030 57 by by IN cord-010092-uftc8inx 4030 58 operators operator NNS cord-010092-uftc8inx 4030 59 recognized recognize VBN cord-010092-uftc8inx 4030 60 by by IN cord-010092-uftc8inx 4030 61 the the DT cord-010092-uftc8inx 4030 62 system system NN cord-010092-uftc8inx 4030 63 thanks thank NNS cord-010092-uftc8inx 4030 64 to to IN cord-010092-uftc8inx 4030 65 the the DT cord-010092-uftc8inx 4030 66 Bluetooth Bluetooth NNP cord-010092-uftc8inx 4030 67 Low Low NNP cord-010092-uftc8inx 4030 68 Energy Energy NNP cord-010092-uftc8inx 4030 69 auto auto NN cord-010092-uftc8inx 4030 70 - - HYPH cord-010092-uftc8inx 4030 71 signing signing NN cord-010092-uftc8inx 4030 72 device device NN cord-010092-uftc8inx 4030 73 . . . cord-010092-uftc8inx 4031 1 The the DT cord-010092-uftc8inx 4031 2 SCWeb SCWeb NNP cord-010092-uftc8inx 4031 3 â â CD cord-010092-uftc8inx 4031 4 system system NN cord-010092-uftc8inx 4031 5 will will MD cord-010092-uftc8inx 4031 6 be be VB cord-010092-uftc8inx 4031 7 connected connect VBN cord-010092-uftc8inx 4031 8 to to IN cord-010092-uftc8inx 4031 9 the the DT cord-010092-uftc8inx 4031 10 transfusion transfusion NN cord-010092-uftc8inx 4031 11 data datum NNS cord-010092-uftc8inx 4031 12 management management NN cord-010092-uftc8inx 4031 13 system system NN cord-010092-uftc8inx 4031 14 , , , cord-010092-uftc8inx 4031 15 to to TO cord-010092-uftc8inx 4031 16 monitor monitor VB cord-010092-uftc8inx 4031 17 all all PDT cord-010092-uftc8inx 4031 18 the the DT cord-010092-uftc8inx 4031 19 process process NN cord-010092-uftc8inx 4031 20 from from IN cord-010092-uftc8inx 4031 21 the the DT cord-010092-uftc8inx 4031 22 arrival arrival NN cord-010092-uftc8inx 4031 23 of of IN cord-010092-uftc8inx 4031 24 the the DT cord-010092-uftc8inx 4031 25 unit unit NN cord-010092-uftc8inx 4031 26 from from IN cord-010092-uftc8inx 4031 27 the the DT cord-010092-uftc8inx 4031 28 blood blood NN cord-010092-uftc8inx 4031 29 bank bank NN cord-010092-uftc8inx 4031 30 . . . cord-010092-uftc8inx 4032 1 Background background NN cord-010092-uftc8inx 4032 2 : : : cord-010092-uftc8inx 4032 3 he -PRON- PRP cord-010092-uftc8inx 4032 4 blood blood NN cord-010092-uftc8inx 4032 5 banks bank NNS cord-010092-uftc8inx 4032 6 aims aim VBZ cord-010092-uftc8inx 4032 7 at at IN cord-010092-uftc8inx 4032 8 reducing reduce VBG cord-010092-uftc8inx 4032 9 cost cost NN cord-010092-uftc8inx 4032 10 and and CC cord-010092-uftc8inx 4032 11 increasing increase VBG cord-010092-uftc8inx 4032 12 customer customer NN cord-010092-uftc8inx 4032 13 satisfaction satisfaction NN cord-010092-uftc8inx 4032 14 by by IN cord-010092-uftc8inx 4032 15 providing provide VBG cord-010092-uftc8inx 4032 16 quality quality NN cord-010092-uftc8inx 4032 17 in in IN cord-010092-uftc8inx 4032 18 service service NN cord-010092-uftc8inx 4032 19 . . . cord-010092-uftc8inx 4033 1 The the DT cord-010092-uftc8inx 4033 2 quality quality NN cord-010092-uftc8inx 4033 3 in in IN cord-010092-uftc8inx 4033 4 service service NN cord-010092-uftc8inx 4033 5 can can MD cord-010092-uftc8inx 4033 6 be be VB cord-010092-uftc8inx 4033 7 attained attain VBN cord-010092-uftc8inx 4033 8 by by IN cord-010092-uftc8inx 4033 9 streamlining streamline VBG cord-010092-uftc8inx 4033 10 the the DT cord-010092-uftc8inx 4033 11 processes process NNS cord-010092-uftc8inx 4033 12 and and CC cord-010092-uftc8inx 4033 13 restructuring restructure VBG cord-010092-uftc8inx 4033 14 the the DT cord-010092-uftc8inx 4033 15 supply supply NN cord-010092-uftc8inx 4033 16 chain chain NN cord-010092-uftc8inx 4033 17 of of IN cord-010092-uftc8inx 4033 18 the the DT cord-010092-uftc8inx 4033 19 organization organization NN cord-010092-uftc8inx 4033 20 by by IN cord-010092-uftc8inx 4033 21 implementing implement VBG cord-010092-uftc8inx 4033 22 IT IT NNP cord-010092-uftc8inx 4033 23 tools tool NNS cord-010092-uftc8inx 4033 24 . . . cord-010092-uftc8inx 4034 1 Aims aim VBZ cord-010092-uftc8inx 4034 2 : : : cord-010092-uftc8inx 4035 1 Aim Aim NNP cord-010092-uftc8inx 4035 2 is be VBZ cord-010092-uftc8inx 4035 3 to to TO cord-010092-uftc8inx 4035 4 understand understand VB cord-010092-uftc8inx 4035 5 the the DT cord-010092-uftc8inx 4035 6 complex complex JJ cord-010092-uftc8inx 4035 7 flow flow NN cord-010092-uftc8inx 4035 8 of of IN cord-010092-uftc8inx 4035 9 information information NN cord-010092-uftc8inx 4035 10 and and CC cord-010092-uftc8inx 4035 11 processes process NNS cord-010092-uftc8inx 4035 12 within within IN cord-010092-uftc8inx 4035 13 the the DT cord-010092-uftc8inx 4035 14 supply supply NN cord-010092-uftc8inx 4035 15 chain chain NN cord-010092-uftc8inx 4035 16 of of IN cord-010092-uftc8inx 4035 17 the the DT cord-010092-uftc8inx 4035 18 blood blood NN cord-010092-uftc8inx 4035 19 bank bank NN cord-010092-uftc8inx 4035 20 . . . cord-010092-uftc8inx 4036 1 The the DT cord-010092-uftc8inx 4036 2 requirement requirement NN cord-010092-uftc8inx 4036 3 of of IN cord-010092-uftc8inx 4036 4 such such PDT cord-010092-uftc8inx 4036 5 a a DT cord-010092-uftc8inx 4036 6 study study NN cord-010092-uftc8inx 4036 7 is be VBZ cord-010092-uftc8inx 4036 8 a a DT cord-010092-uftc8inx 4036 9 part part NN cord-010092-uftc8inx 4036 10 of of IN cord-010092-uftc8inx 4036 11 the the DT cord-010092-uftc8inx 4036 12 integrated integrate VBN cord-010092-uftc8inx 4036 13 ERP ERP NNP cord-010092-uftc8inx 4036 14 modeling modeling NN cord-010092-uftc8inx 4036 15 for for IN cord-010092-uftc8inx 4036 16 the the DT cord-010092-uftc8inx 4036 17 integrated integrated JJ cord-010092-uftc8inx 4036 18 functioning functioning NN cord-010092-uftc8inx 4036 19 of of IN cord-010092-uftc8inx 4036 20 a a DT cord-010092-uftc8inx 4036 21 blood blood NN cord-010092-uftc8inx 4036 22 bank bank NN cord-010092-uftc8inx 4036 23 . . . cord-010092-uftc8inx 4037 1 Methods method NNS cord-010092-uftc8inx 4038 1 : : : cord-010092-uftc8inx 4038 2 he -PRON- PRP cord-010092-uftc8inx 4038 3 approach approach NN cord-010092-uftc8inx 4038 4 used use VBD cord-010092-uftc8inx 4038 5 to to TO cord-010092-uftc8inx 4038 6 understand understand VB cord-010092-uftc8inx 4038 7 and and CC cord-010092-uftc8inx 4038 8 map map VB cord-010092-uftc8inx 4038 9 the the DT cord-010092-uftc8inx 4038 10 sequence sequence NN cord-010092-uftc8inx 4038 11 of of IN cord-010092-uftc8inx 4038 12 processes process NNS cord-010092-uftc8inx 4038 13 , , , cord-010092-uftc8inx 4038 14 and and CC cord-010092-uftc8inx 4038 15 the the DT cord-010092-uftc8inx 4038 16 work work NN cord-010092-uftc8inx 4038 17 responsibilities responsibility NNS cord-010092-uftc8inx 4038 18 of of IN cord-010092-uftc8inx 4038 19 each each DT cord-010092-uftc8inx 4038 20 process process NN cord-010092-uftc8inx 4038 21 and and CC cord-010092-uftc8inx 4038 22 the the DT cord-010092-uftc8inx 4038 23 operational operational JJ cord-010092-uftc8inx 4038 24 decisions decision NNS cord-010092-uftc8inx 4038 25 involved involve VBN cord-010092-uftc8inx 4038 26 at at IN cord-010092-uftc8inx 4038 27 each each DT cord-010092-uftc8inx 4038 28 step step NN cord-010092-uftc8inx 4038 29 is be VBZ cord-010092-uftc8inx 4038 30 process process NN cord-010092-uftc8inx 4038 31 mapping mapping NN cord-010092-uftc8inx 4038 32 and and CC cord-010092-uftc8inx 4038 33 data data NN cord-010092-uftc8inx 4038 34 flow flow NN cord-010092-uftc8inx 4038 35 diagrams diagram NNS cord-010092-uftc8inx 4038 36 for for IN cord-010092-uftc8inx 4038 37 front front JJ cord-010092-uftc8inx 4038 38 end end NN cord-010092-uftc8inx 4038 39 system system NN cord-010092-uftc8inx 4038 40 modeling modeling NN cord-010092-uftc8inx 4038 41 and and CC cord-010092-uftc8inx 4038 42 analysis analysis NN cord-010092-uftc8inx 4038 43 . . . cord-010092-uftc8inx 4039 1 The the DT cord-010092-uftc8inx 4039 2 processes process NNS cord-010092-uftc8inx 4039 3 are be VBP cord-010092-uftc8inx 4039 4 mapped map VBN cord-010092-uftc8inx 4039 5 and and CC cord-010092-uftc8inx 4039 6 represented represent VBN cord-010092-uftc8inx 4039 7 in in IN cord-010092-uftc8inx 4039 8 a a DT cord-010092-uftc8inx 4039 9 schematic schematic JJ cord-010092-uftc8inx 4039 10 diagram diagram NN cord-010092-uftc8inx 4039 11 . . . cord-010092-uftc8inx 4040 1 DFD DFD NNP cord-010092-uftc8inx 4041 1 ( ( -LRB- cord-010092-uftc8inx 4041 2 Data Data NNP cord-010092-uftc8inx 4041 3 Flow Flow NNP cord-010092-uftc8inx 4041 4 Diagram Diagram NNP cord-010092-uftc8inx 4041 5 ) ) -RRB- cord-010092-uftc8inx 4041 6 are be VBP cord-010092-uftc8inx 4041 7 constructed construct VBN cord-010092-uftc8inx 4041 8 for for IN cord-010092-uftc8inx 4041 9 representing represent VBG cord-010092-uftc8inx 4041 10 the the DT cord-010092-uftc8inx 4041 11 system system NN cord-010092-uftc8inx 4041 12 . . . cord-010092-uftc8inx 4042 1 A a DT cord-010092-uftc8inx 4042 2 context context NN cord-010092-uftc8inx 4042 3 diagram diagram NN cord-010092-uftc8inx 4042 4 is be VBZ cord-010092-uftc8inx 4042 5 also also RB cord-010092-uftc8inx 4042 6 constructed construct VBN cord-010092-uftc8inx 4042 7 for for IN cord-010092-uftc8inx 4042 8 understanding understand VBG cord-010092-uftc8inx 4042 9 the the DT cord-010092-uftc8inx 4042 10 entities entity NNS cord-010092-uftc8inx 4042 11 interacting interact VBG cord-010092-uftc8inx 4042 12 with with IN cord-010092-uftc8inx 4042 13 the the DT cord-010092-uftc8inx 4042 14 system system NN cord-010092-uftc8inx 4042 15 . . . cord-010092-uftc8inx 4043 1 The the DT cord-010092-uftc8inx 4043 2 EMR EMR NNP cord-010092-uftc8inx 4043 3 systems system NNS cord-010092-uftc8inx 4043 4 aim aim VBP cord-010092-uftc8inx 4043 5 at at IN cord-010092-uftc8inx 4043 6 replacing replace VBG cord-010092-uftc8inx 4043 7 ( ( -LRB- cord-010092-uftc8inx 4043 8 or or CC cord-010092-uftc8inx 4043 9 supporting support VBG cord-010092-uftc8inx 4043 10 ) ) -RRB- cord-010092-uftc8inx 4043 11 the the DT cord-010092-uftc8inx 4043 12 paper paper NN cord-010092-uftc8inx 4043 13 based base VBD cord-010092-uftc8inx 4043 14 medical medical JJ cord-010092-uftc8inx 4043 15 records record NNS cord-010092-uftc8inx 4043 16 . . . cord-010092-uftc8inx 4044 1 The the DT cord-010092-uftc8inx 4044 2 whole whole JJ cord-010092-uftc8inx 4044 3 model model NN cord-010092-uftc8inx 4044 4 of of IN cord-010092-uftc8inx 4044 5 the the DT cord-010092-uftc8inx 4044 6 system system NN cord-010092-uftc8inx 4044 7 is be VBZ cord-010092-uftc8inx 4044 8 divided divide VBN cord-010092-uftc8inx 4044 9 into into IN cord-010092-uftc8inx 4044 10 two two CD cord-010092-uftc8inx 4044 11 parts part NNS cord-010092-uftc8inx 4044 12 - - : cord-010092-uftc8inx 4044 13 Front front NN cord-010092-uftc8inx 4044 14 end end NN cord-010092-uftc8inx 4044 15 and and CC cord-010092-uftc8inx 4044 16 Back back JJ cord-010092-uftc8inx 4044 17 end end NN cord-010092-uftc8inx 4044 18 . . . cord-010092-uftc8inx 4045 1 The the DT cord-010092-uftc8inx 4045 2 front front JJ cord-010092-uftc8inx 4045 3 end end NN cord-010092-uftc8inx 4045 4 design design NN cord-010092-uftc8inx 4045 5 and and CC cord-010092-uftc8inx 4045 6 analysis analysis NN cord-010092-uftc8inx 4045 7 is be VBZ cord-010092-uftc8inx 4045 8 done do VBN cord-010092-uftc8inx 4045 9 using use VBG cord-010092-uftc8inx 4045 10 EPC EPC NNP cord-010092-uftc8inx 4045 11 ( ( -LRB- cord-010092-uftc8inx 4045 12 Event event NN cord-010092-uftc8inx 4045 13 - - HYPH cord-010092-uftc8inx 4045 14 Driven Driven NNP cord-010092-uftc8inx 4045 15 Process Process NNP cord-010092-uftc8inx 4045 16 Chains Chains NNPS cord-010092-uftc8inx 4045 17 ) ) -RRB- cord-010092-uftc8inx 4045 18 , , , cord-010092-uftc8inx 4045 19 Resource resource NN cord-010092-uftc8inx 4045 20 Views view NNS cord-010092-uftc8inx 4045 21 , , , cord-010092-uftc8inx 4046 1 Data datum NNS cord-010092-uftc8inx 4046 2 flow flow NN cord-010092-uftc8inx 4046 3 Diagram Diagram NNP cord-010092-uftc8inx 4046 4 for for IN cord-010092-uftc8inx 4046 5 Data Data NNP cord-010092-uftc8inx 4046 6 view view NN cord-010092-uftc8inx 4046 7 . . . cord-010092-uftc8inx 4047 1 Reporting report VBG cord-010092-uftc8inx 4047 2 was be VBD cord-010092-uftc8inx 4047 3 on on IN cord-010092-uftc8inx 4047 4 Donor Donor NNP cord-010092-uftc8inx 4047 5 Selection Selection NNP cord-010092-uftc8inx 4047 6 , , , cord-010092-uftc8inx 4047 7 Finance Finance NNP cord-010092-uftc8inx 4047 8 and and CC cord-010092-uftc8inx 4047 9 Collection Collection NNP cord-010092-uftc8inx 4047 10 of of IN cord-010092-uftc8inx 4047 11 Blood Blood NNP cord-010092-uftc8inx 4047 12 Bag Bag NNP cord-010092-uftc8inx 4047 13 , , , cord-010092-uftc8inx 4047 14 Blood Blood NNP cord-010092-uftc8inx 4047 15 Collection Collection NNP cord-010092-uftc8inx 4047 16 Process Process NNP cord-010092-uftc8inx 4047 17 , , , cord-010092-uftc8inx 4047 18 Component Component NNP cord-010092-uftc8inx 4047 19 Preparation Preparation NNP cord-010092-uftc8inx 4047 20 , , , cord-010092-uftc8inx 4047 21 Blood blood NN cord-010092-uftc8inx 4047 22 Testing testing NN cord-010092-uftc8inx 4047 23 and and CC cord-010092-uftc8inx 4047 24 Blood blood NN cord-010092-uftc8inx 4047 25 Distribution distribution NN cord-010092-uftc8inx 4047 26 Results result NNS cord-010092-uftc8inx 4047 27 : : : cord-010092-uftc8inx 4048 1 Process process NN cord-010092-uftc8inx 4048 2 mapping mapping NN cord-010092-uftc8inx 4048 3 using use VBG cord-010092-uftc8inx 4048 4 Event Event NNP cord-010092-uftc8inx 4048 5 Driven Driven NNP cord-010092-uftc8inx 4048 6 process process NN cord-010092-uftc8inx 4048 7 Chain Chain NNP cord-010092-uftc8inx 4048 8 generated generate VBD cord-010092-uftc8inx 4048 9 a a DT cord-010092-uftc8inx 4048 10 whole whole JJ cord-010092-uftc8inx 4048 11 view view NN cord-010092-uftc8inx 4048 12 of of IN cord-010092-uftc8inx 4048 13 the the DT cord-010092-uftc8inx 4048 14 processes process NNS cord-010092-uftc8inx 4048 15 involved involve VBN cord-010092-uftc8inx 4048 16 . . . cord-010092-uftc8inx 4049 1 The the DT cord-010092-uftc8inx 4049 2 resource resource NN cord-010092-uftc8inx 4049 3 view view NN cord-010092-uftc8inx 4049 4 gave give VBD cord-010092-uftc8inx 4049 5 an an DT cord-010092-uftc8inx 4049 6 organizational organizational JJ cord-010092-uftc8inx 4049 7 structure structure NN cord-010092-uftc8inx 4049 8 and and CC cord-010092-uftc8inx 4049 9 the the DT cord-010092-uftc8inx 4049 10 personnel personnel NNS cord-010092-uftc8inx 4049 11 involved involve VBN cord-010092-uftc8inx 4049 12 . . . cord-010092-uftc8inx 4050 1 The the DT cord-010092-uftc8inx 4050 2 data data NN cord-010092-uftc8inx 4050 3 view view NN cord-010092-uftc8inx 4050 4 using use VBG cord-010092-uftc8inx 4050 5 context context NN cord-010092-uftc8inx 4050 6 diagram diagram NN cord-010092-uftc8inx 4050 7 and and CC cord-010092-uftc8inx 4050 8 data data NN cord-010092-uftc8inx 4050 9 flow flow NN cord-010092-uftc8inx 4050 10 diagram diagram NN cord-010092-uftc8inx 4050 11 gives give VBZ cord-010092-uftc8inx 4050 12 a a DT cord-010092-uftc8inx 4050 13 flow flow NN cord-010092-uftc8inx 4050 14 of of IN cord-010092-uftc8inx 4050 15 data datum NNS cord-010092-uftc8inx 4050 16 and and CC cord-010092-uftc8inx 4050 17 amount amount NN cord-010092-uftc8inx 4050 18 of of IN cord-010092-uftc8inx 4050 19 data datum NNS cord-010092-uftc8inx 4050 20 involved involve VBN cord-010092-uftc8inx 4050 21 . . . cord-010092-uftc8inx 4051 1 This this DT cord-010092-uftc8inx 4051 2 framework framework NN cord-010092-uftc8inx 4051 3 can can MD cord-010092-uftc8inx 4051 4 be be VB cord-010092-uftc8inx 4051 5 used use VBN cord-010092-uftc8inx 4051 6 for for IN cord-010092-uftc8inx 4051 7 business business NN cord-010092-uftc8inx 4051 8 process process NN cord-010092-uftc8inx 4051 9 reengineering reengineere VBG cord-010092-uftc8inx 4051 10 for for IN cord-010092-uftc8inx 4051 11 the the DT cord-010092-uftc8inx 4051 12 blood blood NN cord-010092-uftc8inx 4051 13 banks bank NNS cord-010092-uftc8inx 4051 14 by by IN cord-010092-uftc8inx 4051 15 conducting conduct VBG cord-010092-uftc8inx 4051 16 a a DT cord-010092-uftc8inx 4051 17 time time NN cord-010092-uftc8inx 4051 18 study study NN cord-010092-uftc8inx 4051 19 and and CC cord-010092-uftc8inx 4051 20 removing remove VBG cord-010092-uftc8inx 4051 21 non non JJ cord-010092-uftc8inx 4051 22 value value NN cord-010092-uftc8inx 4051 23 added add VBN cord-010092-uftc8inx 4051 24 activities activity NNS cord-010092-uftc8inx 4051 25 . . . cord-010092-uftc8inx 4052 1 Data datum NNS cord-010092-uftc8inx 4052 2 view view NN cord-010092-uftc8inx 4052 3 helps help VBZ cord-010092-uftc8inx 4052 4 analyze analyze VB cord-010092-uftc8inx 4052 5 redundant redundant JJ cord-010092-uftc8inx 4052 6 data datum NNS cord-010092-uftc8inx 4052 7 in in IN cord-010092-uftc8inx 4052 8 each each DT cord-010092-uftc8inx 4052 9 process process NN cord-010092-uftc8inx 4052 10 . . . cord-010092-uftc8inx 4053 1 It -PRON- PRP cord-010092-uftc8inx 4053 2 also also RB cord-010092-uftc8inx 4053 3 helps help VBZ cord-010092-uftc8inx 4053 4 in in IN cord-010092-uftc8inx 4053 5 staff staff NN cord-010092-uftc8inx 4053 6 training training NN cord-010092-uftc8inx 4053 7 and and CC cord-010092-uftc8inx 4053 8 orientation orientation NN cord-010092-uftc8inx 4053 9 within within IN cord-010092-uftc8inx 4053 10 the the DT cord-010092-uftc8inx 4053 11 department department NN cord-010092-uftc8inx 4053 12 . . . cord-010092-uftc8inx 4054 1 Summary Summary NNP cord-010092-uftc8inx 4054 2 / / SYM cord-010092-uftc8inx 4054 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 4054 4 : : : cord-010092-uftc8inx 4055 1 A a DT cord-010092-uftc8inx 4055 2 systematic systematic JJ cord-010092-uftc8inx 4055 3 overview overview NN cord-010092-uftc8inx 4055 4 presented present VBN cord-010092-uftc8inx 4055 5 in in IN cord-010092-uftc8inx 4055 6 this this DT cord-010092-uftc8inx 4055 7 paper paper NN cord-010092-uftc8inx 4055 8 facilitates facilitate VBZ cord-010092-uftc8inx 4055 9 in in IN cord-010092-uftc8inx 4055 10 removal removal NN cord-010092-uftc8inx 4055 11 of of IN cord-010092-uftc8inx 4055 12 non non JJ cord-010092-uftc8inx 4055 13 value value NN cord-010092-uftc8inx 4055 14 added add VBN cord-010092-uftc8inx 4055 15 processes process NNS cord-010092-uftc8inx 4055 16 , , , cord-010092-uftc8inx 4055 17 duplication duplication NN cord-010092-uftc8inx 4055 18 of of IN cord-010092-uftc8inx 4055 19 data datum NNS cord-010092-uftc8inx 4055 20 , , , cord-010092-uftc8inx 4055 21 bottlenecks bottleneck NNS cord-010092-uftc8inx 4055 22 , , , cord-010092-uftc8inx 4055 23 reduction reduction NN cord-010092-uftc8inx 4055 24 of of IN cord-010092-uftc8inx 4055 25 cycle cycle NN cord-010092-uftc8inx 4055 26 time time NN cord-010092-uftc8inx 4055 27 and and CC cord-010092-uftc8inx 4055 28 thereby thereby RB cord-010092-uftc8inx 4055 29 improving improve VBG cord-010092-uftc8inx 4055 30 service service NN cord-010092-uftc8inx 4055 31 quality quality NN cord-010092-uftc8inx 4055 32 in in IN cord-010092-uftc8inx 4055 33 blood blood NN cord-010092-uftc8inx 4055 34 banks bank NNS cord-010092-uftc8inx 4055 35 . . . cord-010092-uftc8inx 4056 1 Background background NN cord-010092-uftc8inx 4056 2 : : : cord-010092-uftc8inx 4057 1 The the DT cord-010092-uftc8inx 4057 2 transfusion transfusion NN cord-010092-uftc8inx 4057 3 of of IN cord-010092-uftc8inx 4057 4 blood blood NN cord-010092-uftc8inx 4057 5 components component NNS cord-010092-uftc8inx 4057 6 , , , cord-010092-uftc8inx 4057 7 one one CD cord-010092-uftc8inx 4057 8 of of IN cord-010092-uftc8inx 4057 9 the the DT cord-010092-uftc8inx 4057 10 most most RBS cord-010092-uftc8inx 4057 11 prevalent prevalent JJ cord-010092-uftc8inx 4057 12 interventions intervention NNS cord-010092-uftc8inx 4057 13 in in IN cord-010092-uftc8inx 4057 14 clinical clinical JJ cord-010092-uftc8inx 4057 15 practice practice NN cord-010092-uftc8inx 4057 16 is be VBZ cord-010092-uftc8inx 4057 17 a a DT cord-010092-uftc8inx 4057 18 major major JJ cord-010092-uftc8inx 4057 19 expenditure expenditure NN cord-010092-uftc8inx 4057 20 item item NN cord-010092-uftc8inx 4057 21 in in IN cord-010092-uftc8inx 4057 22 healthcare healthcare NN cord-010092-uftc8inx 4057 23 services service NNS cord-010092-uftc8inx 4057 24 which which WDT cord-010092-uftc8inx 4057 25 tend tend VBP cord-010092-uftc8inx 4057 26 to to TO cord-010092-uftc8inx 4057 27 increase increase VB cord-010092-uftc8inx 4057 28 in in IN cord-010092-uftc8inx 4057 29 recent recent JJ cord-010092-uftc8inx 4057 30 years year NNS cord-010092-uftc8inx 4057 31 . . . cord-010092-uftc8inx 4058 1 Aims aim VBZ cord-010092-uftc8inx 4058 2 : : : cord-010092-uftc8inx 4058 3 It -PRON- PRP cord-010092-uftc8inx 4058 4 is be VBZ cord-010092-uftc8inx 4058 5 intended intend VBN cord-010092-uftc8inx 4058 6 to to TO cord-010092-uftc8inx 4058 7 investigate investigate VB cord-010092-uftc8inx 4058 8 the the DT cord-010092-uftc8inx 4058 9 impact impact NN cord-010092-uftc8inx 4058 10 of of IN cord-010092-uftc8inx 4058 11 transfusion transfusion NN cord-010092-uftc8inx 4058 12 associated associate VBN cord-010092-uftc8inx 4058 13 costs cost NNS cord-010092-uftc8inx 4058 14 to to IN cord-010092-uftc8inx 4058 15 hospital hospital NN cord-010092-uftc8inx 4058 16 costs cost NNS cord-010092-uftc8inx 4058 17 in in IN cord-010092-uftc8inx 4058 18 Pediatric Pediatric NNP cord-010092-uftc8inx 4058 19 Intensive Intensive NNP cord-010092-uftc8inx 4058 20 Care Care NNP cord-010092-uftc8inx 4058 21 Unit Unit NNP cord-010092-uftc8inx 4058 22 ( ( -LRB- cord-010092-uftc8inx 4058 23 PICU PICU NNP cord-010092-uftc8inx 4058 24 ) ) -RRB- cord-010092-uftc8inx 4058 25 patients patient NNS cord-010092-uftc8inx 4058 26 . . . cord-010092-uftc8inx 4059 1 Methods method NNS cord-010092-uftc8inx 4059 2 : : : cord-010092-uftc8inx 4059 3 During during IN cord-010092-uftc8inx 4059 4 a a DT cord-010092-uftc8inx 4059 5 year year NN cord-010092-uftc8inx 4059 6 period period NN cord-010092-uftc8inx 4059 7 ( ( -LRB- cord-010092-uftc8inx 4059 8 January January NNP cord-010092-uftc8inx 4059 9 2017-December 2017-december CD cord-010092-uftc8inx 4059 10 2017 2017 CD cord-010092-uftc8inx 4059 11 ) ) -RRB- cord-010092-uftc8inx 4060 1 76 76 CD cord-010092-uftc8inx 4060 2 patients patient NNS cord-010092-uftc8inx 4060 3 , , , cord-010092-uftc8inx 4060 4 40 40 CD cord-010092-uftc8inx 4060 5 females female NNS cord-010092-uftc8inx 4060 6 and and CC cord-010092-uftc8inx 4060 7 36 36 CD cord-010092-uftc8inx 4060 8 males male NNS cord-010092-uftc8inx 4060 9 receiving receive VBG cord-010092-uftc8inx 4060 10 transfusion transfusion NN cord-010092-uftc8inx 4060 11 with with IN cord-010092-uftc8inx 4060 12 blood blood NN cord-010092-uftc8inx 4060 13 components component NNS cord-010092-uftc8inx 4060 14 along along IN cord-010092-uftc8inx 4060 15 the the DT cord-010092-uftc8inx 4060 16 stay stay NN cord-010092-uftc8inx 4060 17 in in IN cord-010092-uftc8inx 4060 18 PICU PICU NNP cord-010092-uftc8inx 4060 19 were be VBD cord-010092-uftc8inx 4060 20 included include VBN cord-010092-uftc8inx 4060 21 in in IN cord-010092-uftc8inx 4060 22 the the DT cord-010092-uftc8inx 4060 23 study study NN cord-010092-uftc8inx 4060 24 . . . cord-010092-uftc8inx 4061 1 Transfusion transfusion NN cord-010092-uftc8inx 4061 2 associated associate VBD cord-010092-uftc8inx 4061 3 costs cost NNS cord-010092-uftc8inx 4061 4 and and CC cord-010092-uftc8inx 4061 5 total total JJ cord-010092-uftc8inx 4061 6 costs cost NNS cord-010092-uftc8inx 4061 7 for for IN cord-010092-uftc8inx 4061 8 healthcare healthcare NN cord-010092-uftc8inx 4061 9 services service NNS cord-010092-uftc8inx 4061 10 for for IN cord-010092-uftc8inx 4061 11 children child NNS cord-010092-uftc8inx 4061 12 treated treat VBN cord-010092-uftc8inx 4061 13 in in IN cord-010092-uftc8inx 4061 14 PICU PICU NNP cord-010092-uftc8inx 4061 15 was be VBD cord-010092-uftc8inx 4061 16 collected collect VBN cord-010092-uftc8inx 4061 17 by by IN cord-010092-uftc8inx 4061 18 using use VBG cord-010092-uftc8inx 4061 19 Hospital Hospital NNP cord-010092-uftc8inx 4061 20 Information Information NNP cord-010092-uftc8inx 4061 21 System System NNP cord-010092-uftc8inx 4061 22 ( ( -LRB- cord-010092-uftc8inx 4061 23 HIS his PRP$ cord-010092-uftc8inx 4061 24 ) ) -RRB- cord-010092-uftc8inx 4061 25 . . . cord-010092-uftc8inx 4062 1 Statistical statistical JJ cord-010092-uftc8inx 4062 2 analysis analysis NN cord-010092-uftc8inx 4062 3 of of IN cord-010092-uftc8inx 4062 4 data datum NNS cord-010092-uftc8inx 4062 5 was be VBD cord-010092-uftc8inx 4062 6 performed perform VBN cord-010092-uftc8inx 4062 7 by by IN cord-010092-uftc8inx 4062 8 SPSS SPSS NNP cord-010092-uftc8inx 4062 9 software software NN cord-010092-uftc8inx 4062 10 ( ( -LRB- cord-010092-uftc8inx 4062 11 version version NN cord-010092-uftc8inx 4062 12 22.0 22.0 CD cord-010092-uftc8inx 4062 13 , , , cord-010092-uftc8inx 4062 14 SPSS SPSS NNP cord-010092-uftc8inx 4062 15 Inc. Inc. NNP cord-010092-uftc8inx 4062 16 , , , cord-010092-uftc8inx 4062 17 Chicago Chicago NNP cord-010092-uftc8inx 4062 18 , , , cord-010092-uftc8inx 4062 19 IL IL NNP cord-010092-uftc8inx 4062 20 , , , cord-010092-uftc8inx 4062 21 USA USA NNP cord-010092-uftc8inx 4062 22 ) ) -RRB- cord-010092-uftc8inx 4062 23 . . . cord-010092-uftc8inx 4063 1 Mann Mann NNP cord-010092-uftc8inx 4063 2 - - HYPH cord-010092-uftc8inx 4063 3 Whitney Whitney NNP cord-010092-uftc8inx 4063 4 U U NNP cord-010092-uftc8inx 4063 5 test test NN cord-010092-uftc8inx 4063 6 and and CC cord-010092-uftc8inx 4063 7 Kruskal Kruskal NNP cord-010092-uftc8inx 4063 8 - - HYPH cord-010092-uftc8inx 4063 9 Wallis Wallis NNP cord-010092-uftc8inx 4063 10 test test NN cord-010092-uftc8inx 4063 11 was be VBD cord-010092-uftc8inx 4063 12 performed perform VBN cord-010092-uftc8inx 4063 13 for for IN cord-010092-uftc8inx 4063 14 comparison comparison NN cord-010092-uftc8inx 4063 15 of of IN cord-010092-uftc8inx 4063 16 independent independent JJ cord-010092-uftc8inx 4063 17 categoric categoric JJ cord-010092-uftc8inx 4063 18 variables variable NNS cord-010092-uftc8inx 4063 19 and and CC cord-010092-uftc8inx 4063 20 numeric numeric JJ cord-010092-uftc8inx 4063 21 data datum NNS cord-010092-uftc8inx 4063 22 ; ; : cord-010092-uftc8inx 4063 23 Chi Chi NNP cord-010092-uftc8inx 4063 24 - - HYPH cord-010092-uftc8inx 4063 25 square square JJ cord-010092-uftc8inx 4063 26 analysis analysis NN cord-010092-uftc8inx 4063 27 was be VBD cord-010092-uftc8inx 4063 28 performed perform VBN cord-010092-uftc8inx 4063 29 for for IN cord-010092-uftc8inx 4063 30 comparison comparison NN cord-010092-uftc8inx 4063 31 of of IN cord-010092-uftc8inx 4063 32 two two CD cord-010092-uftc8inx 4063 33 numeric numeric JJ cord-010092-uftc8inx 4063 34 variables variable NNS cord-010092-uftc8inx 4063 35 and and CC cord-010092-uftc8inx 4063 36 Spearman Spearman NNP cord-010092-uftc8inx 4063 37 correlation correlation NN cord-010092-uftc8inx 4063 38 analysis analysis NN cord-010092-uftc8inx 4063 39 was be VBD cord-010092-uftc8inx 4063 40 performed perform VBN cord-010092-uftc8inx 4063 41 for for IN cord-010092-uftc8inx 4063 42 associations association NNS cord-010092-uftc8inx 4063 43 . . . cord-010092-uftc8inx 4064 1 Results result NNS cord-010092-uftc8inx 4064 2 : : : cord-010092-uftc8inx 4065 1 The the DT cord-010092-uftc8inx 4065 2 median median JJ cord-010092-uftc8inx 4065 3 age age NN cord-010092-uftc8inx 4065 4 of of IN cord-010092-uftc8inx 4065 5 patients patient NNS cord-010092-uftc8inx 4065 6 was be VBD cord-010092-uftc8inx 4065 7 12.0 12.0 CD cord-010092-uftc8inx 4065 8 months month NNS cord-010092-uftc8inx 4065 9 ( ( -LRB- cord-010092-uftc8inx 4065 10 interquantile interquantile JJ cord-010092-uftc8inx 4065 11 range range NNP cord-010092-uftc8inx 4065 12 - - HYPH cord-010092-uftc8inx 4065 13 IQR IQR NNP cord-010092-uftc8inx 4065 14 26 26 CD cord-010092-uftc8inx 4065 15 ) ) -RRB- cord-010092-uftc8inx 4065 16 . . . cord-010092-uftc8inx 4066 1 The the DT cord-010092-uftc8inx 4066 2 median median JJ cord-010092-uftc8inx 4066 3 length length NN cord-010092-uftc8inx 4066 4 of of IN cord-010092-uftc8inx 4066 5 stay stay NN cord-010092-uftc8inx 4066 6 was be VBD cord-010092-uftc8inx 4066 7 16 16 CD cord-010092-uftc8inx 4066 8 days day NNS cord-010092-uftc8inx 4066 9 ( ( -LRB- cord-010092-uftc8inx 4066 10 IQR IQR NNP cord-010092-uftc8inx 4066 11 30 30 CD cord-010092-uftc8inx 4066 12 ) ) -RRB- cord-010092-uftc8inx 4066 13 . . . cord-010092-uftc8inx 4067 1 In in IN cord-010092-uftc8inx 4067 2 total total JJ cord-010092-uftc8inx 4067 3 400 400 CD cord-010092-uftc8inx 4067 4 blood blood NN cord-010092-uftc8inx 4067 5 components component NNS cord-010092-uftc8inx 4067 6 were be VBD cord-010092-uftc8inx 4067 7 transfused transfuse VBN cord-010092-uftc8inx 4067 8 in in IN cord-010092-uftc8inx 4067 9 which which WDT cord-010092-uftc8inx 4067 10 of of IN cord-010092-uftc8inx 4067 11 227 227 CD cord-010092-uftc8inx 4067 12 red red JJ cord-010092-uftc8inx 4067 13 blood blood NN cord-010092-uftc8inx 4067 14 cell cell NN cord-010092-uftc8inx 4067 15 concentrates concentrate VBZ cord-010092-uftc8inx 4068 1 , , , cord-010092-uftc8inx 4068 2 114 114 CD cord-010092-uftc8inx 4068 3 apheresis apheresis NN cord-010092-uftc8inx 4068 4 platelet platelet NN cord-010092-uftc8inx 4068 5 concentrates concentrate VBZ cord-010092-uftc8inx 4068 6 , , , cord-010092-uftc8inx 4068 7 6 6 CD cord-010092-uftc8inx 4068 8 granulocyte granulocyte NN cord-010092-uftc8inx 4068 9 concentrates concentrate VBZ cord-010092-uftc8inx 4068 10 , , , cord-010092-uftc8inx 4068 11 51 51 CD cord-010092-uftc8inx 4068 12 fresh fresh JJ cord-010092-uftc8inx 4068 13 frozen frozen JJ cord-010092-uftc8inx 4068 14 plasmas plasma NNS cord-010092-uftc8inx 4068 15 , , , cord-010092-uftc8inx 4068 16 and and CC cord-010092-uftc8inx 4068 17 1 1 CD cord-010092-uftc8inx 4068 18 cryoprecipitate cryoprecipitate NN cord-010092-uftc8inx 4068 19 and and CC cord-010092-uftc8inx 4068 20 1 1 CD cord-010092-uftc8inx 4068 21 whole whole JJ cord-010092-uftc8inx 4068 22 blood blood NN cord-010092-uftc8inx 4068 23 . . . cord-010092-uftc8inx 4069 1 The the DT cord-010092-uftc8inx 4069 2 ratios ratio NNS cord-010092-uftc8inx 4069 3 of of IN cord-010092-uftc8inx 4069 4 transfusion transfusion NN cord-010092-uftc8inx 4069 5 associated associate VBD cord-010092-uftc8inx 4069 6 expenditures expenditure NNS cord-010092-uftc8inx 4069 7 to to IN cord-010092-uftc8inx 4069 8 hospital hospital NN cord-010092-uftc8inx 4069 9 costs cost NNS cord-010092-uftc8inx 4069 10 were be VBD cord-010092-uftc8inx 4069 11 categorized categorize VBN cord-010092-uftc8inx 4069 12 in in IN cord-010092-uftc8inx 4069 13 intervals interval NNS cord-010092-uftc8inx 4069 14 of of IN cord-010092-uftc8inx 4069 15 percentages percentage NNS cord-010092-uftc8inx 4069 16 as as IN cord-010092-uftc8inx 4069 17 < < NNP cord-010092-uftc8inx 4069 18 5 5 CD cord-010092-uftc8inx 4069 19 % % NN cord-010092-uftc8inx 4069 20 , , , cord-010092-uftc8inx 4069 21 5 5 CD cord-010092-uftc8inx 4069 22 - - SYM cord-010092-uftc8inx 4069 23 10 10 CD cord-010092-uftc8inx 4069 24 % % NN cord-010092-uftc8inx 4069 25 , , , cord-010092-uftc8inx 4069 26 11 11 CD cord-010092-uftc8inx 4069 27 - - SYM cord-010092-uftc8inx 4069 28 15 15 CD cord-010092-uftc8inx 4069 29 % % NN cord-010092-uftc8inx 4069 30 and and CC cord-010092-uftc8inx 4069 31 > > XX cord-010092-uftc8inx 4069 32 15 15 CD cord-010092-uftc8inx 4069 33 % % NN cord-010092-uftc8inx 4069 34 . . . cord-010092-uftc8inx 4070 1 Most Most JJS cord-010092-uftc8inx 4070 2 of of IN cord-010092-uftc8inx 4070 3 the the DT cord-010092-uftc8inx 4070 4 patients patient NNS cord-010092-uftc8inx 4070 5 ( ( -LRB- cord-010092-uftc8inx 4070 6 63.2 63.2 CD cord-010092-uftc8inx 4070 7 % % NN cord-010092-uftc8inx 4070 8 ) ) -RRB- cord-010092-uftc8inx 4070 9 were be VBD cord-010092-uftc8inx 4070 10 ranked rank VBN cord-010092-uftc8inx 4070 11 in in IN cord-010092-uftc8inx 4070 12 the the DT cord-010092-uftc8inx 4070 13 lowest low JJS cord-010092-uftc8inx 4070 14 interval interval NN cord-010092-uftc8inx 4070 15 . . . cord-010092-uftc8inx 4071 1 The the DT cord-010092-uftc8inx 4071 2 medians median NNS cord-010092-uftc8inx 4071 3 for for IN cord-010092-uftc8inx 4071 4 hospital hospital NN cord-010092-uftc8inx 4071 5 cost cost NN cord-010092-uftc8inx 4071 6 and and CC cord-010092-uftc8inx 4071 7 transfusion transfusion NN cord-010092-uftc8inx 4071 8 associated associate VBN cord-010092-uftc8inx 4071 9 cost cost NN cord-010092-uftc8inx 4071 10 were be VBD cord-010092-uftc8inx 4071 11 5478.76 5478.76 CD cord-010092-uftc8inx 4071 12 euros euro NNS cord-010092-uftc8inx 4071 13 ( ( -LRB- cord-010092-uftc8inx 4071 14 IQR iqr NN cord-010092-uftc8inx 4071 15 = = SYM cord-010092-uftc8inx 4071 16 11280.02 11280.02 CD cord-010092-uftc8inx 4071 17 ) ) -RRB- cord-010092-uftc8inx 4071 18 and and CC cord-010092-uftc8inx 4071 19 130.57 130.57 CD cord-010092-uftc8inx 4071 20 euros euro NNS cord-010092-uftc8inx 4071 21 ( ( -LRB- cord-010092-uftc8inx 4071 22 IQR iqr NN cord-010092-uftc8inx 4071 23 = = SYM cord-010092-uftc8inx 4071 24 354.86 354.86 CD cord-010092-uftc8inx 4071 25 ) ) -RRB- cord-010092-uftc8inx 4071 26 , , , cord-010092-uftc8inx 4071 27 respectively respectively RB cord-010092-uftc8inx 4071 28 . . . cord-010092-uftc8inx 4072 1 A a DT cord-010092-uftc8inx 4072 2 significant significant JJ cord-010092-uftc8inx 4072 3 strong strong JJ cord-010092-uftc8inx 4072 4 positive positive JJ cord-010092-uftc8inx 4072 5 correlation correlation NN cord-010092-uftc8inx 4072 6 between between IN cord-010092-uftc8inx 4072 7 numbers number NNS cord-010092-uftc8inx 4072 8 of of IN cord-010092-uftc8inx 4072 9 transfusions transfusion NNS cord-010092-uftc8inx 4072 10 and and CC cord-010092-uftc8inx 4072 11 hospitalization hospitalization NN cord-010092-uftc8inx 4072 12 cost cost NN cord-010092-uftc8inx 4072 13 of of IN cord-010092-uftc8inx 4072 14 PICU PICU NNP cord-010092-uftc8inx 4072 15 was be VBD cord-010092-uftc8inx 4072 16 detected detect VBN cord-010092-uftc8inx 4073 1 ( ( -LRB- cord-010092-uftc8inx 4073 2 r r NN cord-010092-uftc8inx 4073 3 : : : cord-010092-uftc8inx 4073 4 0.674 0.674 CD cord-010092-uftc8inx 4073 5 , , , cord-010092-uftc8inx 4073 6 P p NN cord-010092-uftc8inx 4073 7 < < XX cord-010092-uftc8inx 4073 8 0.01 0.01 CD cord-010092-uftc8inx 4073 9 ) ) -RRB- cord-010092-uftc8inx 4073 10 . . . cord-010092-uftc8inx 4074 1 While while IN cord-010092-uftc8inx 4074 2 it -PRON- PRP cord-010092-uftc8inx 4074 3 was be VBD cord-010092-uftc8inx 4074 4 found find VBN cord-010092-uftc8inx 4074 5 a a DT cord-010092-uftc8inx 4074 6 significant significant JJ cord-010092-uftc8inx 4074 7 weak weak JJ cord-010092-uftc8inx 4074 8 positive positive JJ cord-010092-uftc8inx 4074 9 correlation correlation NN cord-010092-uftc8inx 4074 10 between between IN cord-010092-uftc8inx 4074 11 transfusion transfusion NN cord-010092-uftc8inx 4074 12 associated associate VBN cord-010092-uftc8inx 4074 13 cost cost NN cord-010092-uftc8inx 4074 14 and and CC cord-010092-uftc8inx 4074 15 hospital hospital NN cord-010092-uftc8inx 4074 16 cost cost NN cord-010092-uftc8inx 4075 1 ( ( -LRB- cord-010092-uftc8inx 4075 2 r r NN cord-010092-uftc8inx 4075 3 : : : cord-010092-uftc8inx 4075 4 0.247 0.247 CD cord-010092-uftc8inx 4075 5 , , , cord-010092-uftc8inx 4075 6 P p NN cord-010092-uftc8inx 4075 7 = = SYM cord-010092-uftc8inx 4075 8 0.032 0.032 CD cord-010092-uftc8inx 4075 9 ) ) -RRB- cord-010092-uftc8inx 4076 1 there there EX cord-010092-uftc8inx 4076 2 was be VBD cord-010092-uftc8inx 4076 3 also also RB cord-010092-uftc8inx 4076 4 a a DT cord-010092-uftc8inx 4076 5 significant significant JJ cord-010092-uftc8inx 4076 6 weak weak JJ cord-010092-uftc8inx 4076 7 positive positive JJ cord-010092-uftc8inx 4076 8 correlation correlation NN cord-010092-uftc8inx 4076 9 between between IN cord-010092-uftc8inx 4076 10 the the DT cord-010092-uftc8inx 4076 11 age age NN cord-010092-uftc8inx 4076 12 and and CC cord-010092-uftc8inx 4076 13 transfusion transfusion NN cord-010092-uftc8inx 4076 14 associated associate VBN cord-010092-uftc8inx 4076 15 cost cost NN cord-010092-uftc8inx 4076 16 ( ( -LRB- cord-010092-uftc8inx 4076 17 P p NN cord-010092-uftc8inx 4076 18 = = SYM cord-010092-uftc8inx 4076 19 0.048 0.048 CD cord-010092-uftc8inx 4076 20 , , , cord-010092-uftc8inx 4076 21 r r NN cord-010092-uftc8inx 4076 22 : : : cord-010092-uftc8inx 4076 23 0.227 0.227 CD cord-010092-uftc8inx 4076 24 ) ) -RRB- cord-010092-uftc8inx 4076 25 . . . cord-010092-uftc8inx 4077 1 A a DT cord-010092-uftc8inx 4077 2 significant significant JJ cord-010092-uftc8inx 4077 3 difference difference NN cord-010092-uftc8inx 4077 4 was be VBD cord-010092-uftc8inx 4077 5 found find VBN cord-010092-uftc8inx 4077 6 between between IN cord-010092-uftc8inx 4077 7 the the DT cord-010092-uftc8inx 4077 8 patients patient NNS cord-010092-uftc8inx 4077 9 with with IN cord-010092-uftc8inx 4077 10 and and CC cord-010092-uftc8inx 4077 11 without without IN cord-010092-uftc8inx 4077 12 hematological hematological JJ cord-010092-uftc8inx 4077 13 malignancies malignancy NNS cord-010092-uftc8inx 4077 14 ( ( -LRB- cord-010092-uftc8inx 4077 15 P p NN cord-010092-uftc8inx 4077 16 < < XX cord-010092-uftc8inx 4077 17 0.01 0.01 CD cord-010092-uftc8inx 4077 18 ) ) -RRB- cord-010092-uftc8inx 4077 19 for for IN cord-010092-uftc8inx 4077 20 transfusion transfusion NN cord-010092-uftc8inx 4077 21 associated associate VBN cord-010092-uftc8inx 4077 22 cost cost NN cord-010092-uftc8inx 4077 23 . . . cord-010092-uftc8inx 4078 1 The the DT cord-010092-uftc8inx 4078 2 reason reason NN cord-010092-uftc8inx 4078 3 why why WRB cord-010092-uftc8inx 4078 4 pediatric pediatric JJ cord-010092-uftc8inx 4078 5 dosages dosage NNS cord-010092-uftc8inx 4078 6 are be VBP cord-010092-uftc8inx 4078 7 mostly mostly RB cord-010092-uftc8inx 4078 8 prefer prefer VBP cord-010092-uftc8inx 4078 9 is be VBZ cord-010092-uftc8inx 4078 10 that that IN cord-010092-uftc8inx 4078 11 the the DT cord-010092-uftc8inx 4078 12 hospital hospital NN cord-010092-uftc8inx 4078 13 provides provide VBZ cord-010092-uftc8inx 4078 14 healthcare healthcare NN cord-010092-uftc8inx 4078 15 for for IN cord-010092-uftc8inx 4078 16 only only JJ cord-010092-uftc8inx 4078 17 children child NNS cord-010092-uftc8inx 4078 18 and and CC cord-010092-uftc8inx 4078 19 splitting splitting NN cord-010092-uftc8inx 4078 20 of of IN cord-010092-uftc8inx 4078 21 the the DT cord-010092-uftc8inx 4078 22 blood blood NN cord-010092-uftc8inx 4078 23 components component NNS cord-010092-uftc8inx 4078 24 was be VBD cord-010092-uftc8inx 4078 25 common common JJ cord-010092-uftc8inx 4078 26 in in IN cord-010092-uftc8inx 4078 27 the the DT cord-010092-uftc8inx 4078 28 hospital hospital NN cord-010092-uftc8inx 4078 29 . . . cord-010092-uftc8inx 4079 1 But but CC cord-010092-uftc8inx 4079 2 unexpectedly unexpectedly RB cord-010092-uftc8inx 4079 3 a a DT cord-010092-uftc8inx 4079 4 significant significant JJ cord-010092-uftc8inx 4079 5 increase increase NN cord-010092-uftc8inx 4079 6 on on IN cord-010092-uftc8inx 4079 7 the the DT cord-010092-uftc8inx 4079 8 transfusion transfusion NN cord-010092-uftc8inx 4079 9 associated associate VBN cord-010092-uftc8inx 4079 10 costs cost NNS cord-010092-uftc8inx 4079 11 which which WDT cord-010092-uftc8inx 4079 12 is be VBZ cord-010092-uftc8inx 4079 13 related relate VBN cord-010092-uftc8inx 4079 14 to to TO cord-010092-uftc8inx 4079 15 split split VB cord-010092-uftc8inx 4079 16 blood blood NN cord-010092-uftc8inx 4079 17 components component NNS cord-010092-uftc8inx 4079 18 was be VBD cord-010092-uftc8inx 4079 19 detected detect VBN cord-010092-uftc8inx 4079 20 ( ( -LRB- cord-010092-uftc8inx 4079 21 P p NN cord-010092-uftc8inx 4079 22 < < XX cord-010092-uftc8inx 4079 23 0.05 0.05 CD cord-010092-uftc8inx 4079 24 ) ) -RRB- cord-010092-uftc8inx 4079 25 . . . cord-010092-uftc8inx 4080 1 Summary Summary NNP cord-010092-uftc8inx 4080 2 / / SYM cord-010092-uftc8inx 4080 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 4080 4 : : : cord-010092-uftc8inx 4081 1 Studies study NNS cord-010092-uftc8inx 4081 2 on on IN cord-010092-uftc8inx 4081 3 the the DT cord-010092-uftc8inx 4081 4 economics economic NNS cord-010092-uftc8inx 4081 5 of of IN cord-010092-uftc8inx 4081 6 blood blood NN cord-010092-uftc8inx 4081 7 transfusion transfusion NN cord-010092-uftc8inx 4081 8 have have VBP cord-010092-uftc8inx 4081 9 been be VBN cord-010092-uftc8inx 4081 10 conducted conduct VBN cord-010092-uftc8inx 4081 11 mostly mostly RB cord-010092-uftc8inx 4081 12 in in IN cord-010092-uftc8inx 4081 13 patients patient NNS cord-010092-uftc8inx 4081 14 who who WP cord-010092-uftc8inx 4081 15 require require VBP cord-010092-uftc8inx 4081 16 chronic chronic JJ cord-010092-uftc8inx 4081 17 or or CC cord-010092-uftc8inx 4081 18 multiple multiple JJ cord-010092-uftc8inx 4081 19 transfusions transfusion NNS cord-010092-uftc8inx 4081 20 . . . cord-010092-uftc8inx 4082 1 PICUs PICUs NNP cord-010092-uftc8inx 4082 2 , , , cord-010092-uftc8inx 4082 3 specialized specialized JJ cord-010092-uftc8inx 4082 4 facilities facility NNS cord-010092-uftc8inx 4082 5 that that WDT cord-010092-uftc8inx 4082 6 provide provide VBP cord-010092-uftc8inx 4082 7 care care NN cord-010092-uftc8inx 4082 8 for for IN cord-010092-uftc8inx 4082 9 patients patient NNS cord-010092-uftc8inx 4082 10 with with IN cord-010092-uftc8inx 4082 11 severe severe JJ cord-010092-uftc8inx 4082 12 life life NN cord-010092-uftc8inx 4082 13 - - HYPH cord-010092-uftc8inx 4082 14 threatening threaten VBG cord-010092-uftc8inx 4082 15 diseases disease NNS cord-010092-uftc8inx 4082 16 are be VBP cord-010092-uftc8inx 4082 17 major major JJ cord-010092-uftc8inx 4082 18 departments department NNS cord-010092-uftc8inx 4082 19 often often RB cord-010092-uftc8inx 4082 20 necessitate necessitate VBP cord-010092-uftc8inx 4082 21 multiple multiple JJ cord-010092-uftc8inx 4082 22 transfusions transfusion NNS cord-010092-uftc8inx 4082 23 . . . cord-010092-uftc8inx 4083 1 There there EX cord-010092-uftc8inx 4083 2 are be VBP cord-010092-uftc8inx 4083 3 many many JJ cord-010092-uftc8inx 4083 4 variables variable NNS cord-010092-uftc8inx 4083 5 to to TO cord-010092-uftc8inx 4083 6 evaluate evaluate VB cord-010092-uftc8inx 4083 7 the the DT cord-010092-uftc8inx 4083 8 impact impact NN cord-010092-uftc8inx 4083 9 of of IN cord-010092-uftc8inx 4083 10 transfusion transfusion NN cord-010092-uftc8inx 4083 11 associated associate VBN cord-010092-uftc8inx 4083 12 cost cost NN cord-010092-uftc8inx 4083 13 to to IN cord-010092-uftc8inx 4083 14 hospital hospital NN cord-010092-uftc8inx 4083 15 cost cost NN cord-010092-uftc8inx 4083 16 in in IN cord-010092-uftc8inx 4083 17 PICU PICU NNP cord-010092-uftc8inx 4083 18 patients patient NNS cord-010092-uftc8inx 4083 19 , , , cord-010092-uftc8inx 4083 20 but but CC cord-010092-uftc8inx 4083 21 the the DT cord-010092-uftc8inx 4083 22 major major JJ cord-010092-uftc8inx 4083 23 factors factor NNS cord-010092-uftc8inx 4083 24 are be VBP cord-010092-uftc8inx 4083 25 underlying underlie VBG cord-010092-uftc8inx 4083 26 conditions condition NNS cord-010092-uftc8inx 4083 27 , , , cord-010092-uftc8inx 4083 28 admitting admit VBG cord-010092-uftc8inx 4083 29 diagnoses diagnosis NNS cord-010092-uftc8inx 4083 30 and and CC cord-010092-uftc8inx 4083 31 transfusion transfusion NN cord-010092-uftc8inx 4083 32 strategies strategy NNS cord-010092-uftc8inx 4083 33 . . . cord-010092-uftc8inx 4084 1 Although although IN cord-010092-uftc8inx 4084 2 there there EX cord-010092-uftc8inx 4084 3 are be VBP cord-010092-uftc8inx 4084 4 unexpected unexpected JJ cord-010092-uftc8inx 4084 5 data datum NNS cord-010092-uftc8inx 4084 6 in in IN cord-010092-uftc8inx 4084 7 our -PRON- PRP$ cord-010092-uftc8inx 4084 8 study study NN cord-010092-uftc8inx 4084 9 demonstrated demonstrate VBD cord-010092-uftc8inx 4084 10 the the DT cord-010092-uftc8inx 4084 11 increasing increase VBG cord-010092-uftc8inx 4084 12 impact impact NN cord-010092-uftc8inx 4084 13 on on IN cord-010092-uftc8inx 4084 14 transfusion transfusion NN cord-010092-uftc8inx 4084 15 associated associate VBN cord-010092-uftc8inx 4084 16 cost cost NN cord-010092-uftc8inx 4084 17 originated originate VBD cord-010092-uftc8inx 4084 18 from from IN cord-010092-uftc8inx 4084 19 blood blood NN cord-010092-uftc8inx 4084 20 components component NNS cord-010092-uftc8inx 4084 21 split split VBD cord-010092-uftc8inx 4084 22 for for IN cord-010092-uftc8inx 4084 23 pediatric pediatric JJ cord-010092-uftc8inx 4084 24 usage usage NN cord-010092-uftc8inx 4084 25 no no DT cord-010092-uftc8inx 4084 26 significant significant JJ cord-010092-uftc8inx 4084 27 relationship relationship NN cord-010092-uftc8inx 4084 28 was be VBD cord-010092-uftc8inx 4084 29 determined determine VBN cord-010092-uftc8inx 4084 30 to to TO cord-010092-uftc8inx 4084 31 explain explain VB cord-010092-uftc8inx 4084 32 this this DT cord-010092-uftc8inx 4084 33 situation situation NN cord-010092-uftc8inx 4084 34 . . . cord-010092-uftc8inx 4085 1 Further further JJ cord-010092-uftc8inx 4085 2 studies study NNS cord-010092-uftc8inx 4085 3 on on IN cord-010092-uftc8inx 4085 4 the the DT cord-010092-uftc8inx 4085 5 economics economic NNS cord-010092-uftc8inx 4085 6 of of IN cord-010092-uftc8inx 4085 7 blood blood NN cord-010092-uftc8inx 4085 8 transfusions transfusion NNS cord-010092-uftc8inx 4085 9 have have VBP cord-010092-uftc8inx 4085 10 to to TO cord-010092-uftc8inx 4085 11 be be VB cord-010092-uftc8inx 4085 12 carried carry VBN cord-010092-uftc8inx 4085 13 out out RP cord-010092-uftc8inx 4085 14 to to TO cord-010092-uftc8inx 4085 15 clarify clarify VB cord-010092-uftc8inx 4085 16 the the DT cord-010092-uftc8inx 4085 17 variables variable NNS cord-010092-uftc8inx 4085 18 of of IN cord-010092-uftc8inx 4085 19 transfusion transfusion NN cord-010092-uftc8inx 4085 20 associated associate VBN cord-010092-uftc8inx 4085 21 costs cost NNS cord-010092-uftc8inx 4085 22 . . . cord-010092-uftc8inx 4086 1 Background background NN cord-010092-uftc8inx 4086 2 : : : cord-010092-uftc8inx 4087 1 Approximately approximately RB cord-010092-uftc8inx 4087 2 55.7 55.7 CD cord-010092-uftc8inx 4087 3 % % NN cord-010092-uftc8inx 4087 4 of of IN cord-010092-uftc8inx 4087 5 the the DT cord-010092-uftc8inx 4087 6 transfused transfuse VBN cord-010092-uftc8inx 4087 7 blood blood NN cord-010092-uftc8inx 4087 8 component component NN cord-010092-uftc8inx 4087 9 is be VBZ cord-010092-uftc8inx 4087 10 packed pack VBN cord-010092-uftc8inx 4087 11 red red JJ cord-010092-uftc8inx 4087 12 cell cell NN cord-010092-uftc8inx 4087 13 ( ( -LRB- cord-010092-uftc8inx 4087 14 PRC PRC NNP cord-010092-uftc8inx 4087 15 ) ) -RRB- cord-010092-uftc8inx 4087 16 . . . cord-010092-uftc8inx 4088 1 Over over IN cord-010092-uftc8inx 4088 2 ordering ordering NN cord-010092-uftc8inx 4088 3 of of IN cord-010092-uftc8inx 4088 4 PRC PRC NNP cord-010092-uftc8inx 4088 5 unit unit NN cord-010092-uftc8inx 4088 6 is be VBZ cord-010092-uftc8inx 4088 7 a a DT cord-010092-uftc8inx 4088 8 common common JJ cord-010092-uftc8inx 4088 9 practice practice NN cord-010092-uftc8inx 4088 10 and and CC cord-010092-uftc8inx 4088 11 excessive excessive JJ cord-010092-uftc8inx 4088 12 pretransfusion pretransfusion NN cord-010092-uftc8inx 4088 13 testing testing NN cord-010092-uftc8inx 4088 14 was be VBD cord-010092-uftc8inx 4088 15 being be VBG cord-010092-uftc8inx 4088 16 wasteful wasteful JJ cord-010092-uftc8inx 4088 17 of of IN cord-010092-uftc8inx 4088 18 resources resource NNS cord-010092-uftc8inx 4088 19 and and CC cord-010092-uftc8inx 4088 20 have have VBP cord-010092-uftc8inx 4088 21 adverse adverse JJ cord-010092-uftc8inx 4088 22 consequences consequence NNS cord-010092-uftc8inx 4088 23 on on IN cord-010092-uftc8inx 4088 24 cost cost NN cord-010092-uftc8inx 4088 25 . . . cord-010092-uftc8inx 4089 1 High high JJ cord-010092-uftc8inx 4089 2 crossmatch crossmatch NN cord-010092-uftc8inx 4089 3 to to IN cord-010092-uftc8inx 4089 4 transfusion transfusion NN cord-010092-uftc8inx 4089 5 ( ( -LRB- cord-010092-uftc8inx 4089 6 C C NNP cord-010092-uftc8inx 4089 7 / / SYM cord-010092-uftc8inx 4089 8 T T NNP cord-010092-uftc8inx 4089 9 ) ) -RRB- cord-010092-uftc8inx 4089 10 ratio ratio NN cord-010092-uftc8inx 4089 11 as as IN cord-010092-uftc8inx 4089 12 quality quality NN cord-010092-uftc8inx 4089 13 indicator indicator NN cord-010092-uftc8inx 4089 14 of of IN cord-010092-uftc8inx 4089 15 blood blood NN cord-010092-uftc8inx 4089 16 bank bank NN cord-010092-uftc8inx 4089 17 implies imply VBZ cord-010092-uftc8inx 4089 18 that that IN cord-010092-uftc8inx 4089 19 crossmatches crossmatche NNS cord-010092-uftc8inx 4089 20 were be VBD cord-010092-uftc8inx 4089 21 performed perform VBN cord-010092-uftc8inx 4089 22 unnecessarily unnecessarily RB cord-010092-uftc8inx 4089 23 . . . cord-010092-uftc8inx 4090 1 Aims aim VBZ cord-010092-uftc8inx 4090 2 : : : cord-010092-uftc8inx 4091 1 The the DT cord-010092-uftc8inx 4091 2 aims aim NNS cord-010092-uftc8inx 4091 3 of of IN cord-010092-uftc8inx 4091 4 this this DT cord-010092-uftc8inx 4091 5 study study NN cord-010092-uftc8inx 4091 6 were be VBD cord-010092-uftc8inx 4091 7 to to TO cord-010092-uftc8inx 4091 8 evaluate evaluate VB cord-010092-uftc8inx 4091 9 the the DT cord-010092-uftc8inx 4091 10 cost cost NN cord-010092-uftc8inx 4091 11 effectiveness effectiveness NN cord-010092-uftc8inx 4091 12 of of IN cord-010092-uftc8inx 4091 13 strategies strategy NNS cord-010092-uftc8inx 4091 14 for for IN cord-010092-uftc8inx 4091 15 limiting limit VBG cord-010092-uftc8inx 4091 16 the the DT cord-010092-uftc8inx 4091 17 number number NN cord-010092-uftc8inx 4091 18 of of IN cord-010092-uftc8inx 4091 19 pretransfusion pretransfusion NN cord-010092-uftc8inx 4091 20 testing testing NN cord-010092-uftc8inx 4091 21 of of IN cord-010092-uftc8inx 4091 22 ordering order VBG cord-010092-uftc8inx 4091 23 PRC PRC NNP cord-010092-uftc8inx 4091 24 . . . cord-010092-uftc8inx 4092 1 Methods method NNS cord-010092-uftc8inx 4092 2 : : : cord-010092-uftc8inx 4093 1 All all DT cord-010092-uftc8inx 4093 2 PRC PRC NNP cord-010092-uftc8inx 4093 3 units unit NNS cord-010092-uftc8inx 4093 4 who who WP cord-010092-uftc8inx 4093 5 ordered order VBD cord-010092-uftc8inx 4093 6 from from IN cord-010092-uftc8inx 4093 7 Dr. Dr. NNP cord-010092-uftc8inx 4093 8 Hasan Hasan NNP cord-010092-uftc8inx 4093 9 Sadikin Sadikin NNP cord-010092-uftc8inx 4093 10 Hospital Hospital NNP cord-010092-uftc8inx 4093 11 from from IN cord-010092-uftc8inx 4093 12 January January NNP cord-010092-uftc8inx 4093 13 2016 2016 CD cord-010092-uftc8inx 4093 14 to to IN cord-010092-uftc8inx 4093 15 December December NNP cord-010092-uftc8inx 4093 16 2018 2018 CD cord-010092-uftc8inx 4093 17 were be VBD cord-010092-uftc8inx 4093 18 collected collect VBN cord-010092-uftc8inx 4093 19 in in IN cord-010092-uftc8inx 4093 20 this this DT cord-010092-uftc8inx 4093 21 retrospective retrospective JJ cord-010092-uftc8inx 4093 22 study study NN cord-010092-uftc8inx 4093 23 . . . cord-010092-uftc8inx 4094 1 Number number NN cord-010092-uftc8inx 4094 2 of of IN cord-010092-uftc8inx 4094 3 ordering order VBG cord-010092-uftc8inx 4094 4 PRC PRC NNP cord-010092-uftc8inx 4094 5 unit unit NN cord-010092-uftc8inx 4094 6 , , , cord-010092-uftc8inx 4094 7 completed complete VBD cord-010092-uftc8inx 4094 8 pretransfusion pretransfusion NN cord-010092-uftc8inx 4094 9 testing testing NN cord-010092-uftc8inx 4094 10 of of IN cord-010092-uftc8inx 4094 11 ordering order VBG cord-010092-uftc8inx 4094 12 PRC PRC NNP cord-010092-uftc8inx 4094 13 units unit NNS cord-010092-uftc8inx 4094 14 , , , cord-010092-uftc8inx 4094 15 and and CC cord-010092-uftc8inx 4094 16 PRC PRC NNP cord-010092-uftc8inx 4094 17 units unit NNS cord-010092-uftc8inx 4094 18 that that WDT cord-010092-uftc8inx 4094 19 were be VBD cord-010092-uftc8inx 4094 20 transfused transfuse VBN cord-010092-uftc8inx 4094 21 were be VBD cord-010092-uftc8inx 4094 22 recorded record VBN cord-010092-uftc8inx 4094 23 . . . cord-010092-uftc8inx 4095 1 Restrictive restrictive JJ cord-010092-uftc8inx 4095 2 pretransfusion pretransfusion NN cord-010092-uftc8inx 4095 3 testing testing NN cord-010092-uftc8inx 4095 4 strategies strategy NNS cord-010092-uftc8inx 4095 5 were be VBD cord-010092-uftc8inx 4095 6 done do VBN cord-010092-uftc8inx 4095 7 based base VBN cord-010092-uftc8inx 4095 8 on on IN cord-010092-uftc8inx 4095 9 the the DT cord-010092-uftc8inx 4095 10 hemoglobin hemoglobin NN cord-010092-uftc8inx 4095 11 level level NN cord-010092-uftc8inx 4095 12 and and CC cord-010092-uftc8inx 4095 13 diagnosis diagnosis NN cord-010092-uftc8inx 4095 14 as as IN cord-010092-uftc8inx 4095 15 transfusion transfusion NN cord-010092-uftc8inx 4095 16 indication indication NN cord-010092-uftc8inx 4095 17 criteria criterion NNS cord-010092-uftc8inx 4095 18 . . . cord-010092-uftc8inx 4096 1 Cost cost NN cord-010092-uftc8inx 4096 2 effectiveness effectiveness NN cord-010092-uftc8inx 4096 3 was be VBD cord-010092-uftc8inx 4096 4 measured measure VBN cord-010092-uftc8inx 4096 5 by by IN cord-010092-uftc8inx 4096 6 multiplying multiply VBG cord-010092-uftc8inx 4096 7 the the DT cord-010092-uftc8inx 4096 8 unit unit NN cord-010092-uftc8inx 4096 9 cost cost NN cord-010092-uftc8inx 4096 10 of of IN cord-010092-uftc8inx 4096 11 pretransfusion pretransfusion NN cord-010092-uftc8inx 4096 12 testing testing NN cord-010092-uftc8inx 4096 13 and and CC cord-010092-uftc8inx 4096 14 number number NN cord-010092-uftc8inx 4096 15 of of IN cord-010092-uftc8inx 4096 16 PRC PRC NNP cord-010092-uftc8inx 4096 17 unit unit NN cord-010092-uftc8inx 4096 18 . . . cord-010092-uftc8inx 4097 1 Results result NNS cord-010092-uftc8inx 4097 2 : : : cord-010092-uftc8inx 4098 1 Out out IN cord-010092-uftc8inx 4098 2 of of IN cord-010092-uftc8inx 4098 3 total total JJ cord-010092-uftc8inx 4098 4 177,370 177,370 CD cord-010092-uftc8inx 4098 5 ordered order VBN cord-010092-uftc8inx 4098 6 PRC PRC NNP cord-010092-uftc8inx 4098 7 unit unit NN cord-010092-uftc8inx 4098 8 , , , cord-010092-uftc8inx 4098 9 166,910 166,910 CD cord-010092-uftc8inx 4098 10 ( ( -LRB- cord-010092-uftc8inx 4098 11 94.1 94.1 CD cord-010092-uftc8inx 4098 12 % % NN cord-010092-uftc8inx 4098 13 ) ) -RRB- cord-010092-uftc8inx 4098 14 were be VBD cord-010092-uftc8inx 4098 15 subjected subject VBN cord-010092-uftc8inx 4098 16 to to IN cord-010092-uftc8inx 4098 17 pretransfusion pretransfusion NN cord-010092-uftc8inx 4098 18 testing testing NN cord-010092-uftc8inx 4098 19 and and CC cord-010092-uftc8inx 4098 20 63.1 63.1 CD cord-010092-uftc8inx 4098 21 % % NN cord-010092-uftc8inx 4098 22 ( ( -LRB- cord-010092-uftc8inx 4098 23 105,260 105,260 CD cord-010092-uftc8inx 4098 24 ) ) -RRB- cord-010092-uftc8inx 4098 25 of of IN cord-010092-uftc8inx 4098 26 ordering order VBG cord-010092-uftc8inx 4098 27 PRC PRC NNP cord-010092-uftc8inx 4098 28 unit unit NN cord-010092-uftc8inx 4098 29 which which WDT cord-010092-uftc8inx 4098 30 are be VBP cord-010092-uftc8inx 4098 31 pretransfusion pretransfusion NN cord-010092-uftc8inx 4098 32 testing testing NN cord-010092-uftc8inx 4098 33 were be VBD cord-010092-uftc8inx 4098 34 transfused transfuse VBN cord-010092-uftc8inx 4098 35 . . . cord-010092-uftc8inx 4099 1 This this DT cord-010092-uftc8inx 4099 2 means mean VBZ cord-010092-uftc8inx 4099 3 that that IN cord-010092-uftc8inx 4099 4 5.9 5.9 CD cord-010092-uftc8inx 4099 5 % % NN cord-010092-uftc8inx 4099 6 ( ( -LRB- cord-010092-uftc8inx 4099 7 10,460 10,460 CD cord-010092-uftc8inx 4099 8 ) ) -RRB- cord-010092-uftc8inx 4099 9 of of IN cord-010092-uftc8inx 4099 10 ordering order VBG cord-010092-uftc8inx 4099 11 PRC PRC NNP cord-010092-uftc8inx 4099 12 unit unit NN cord-010092-uftc8inx 4099 13 were be VBD cord-010092-uftc8inx 4099 14 not not RB cord-010092-uftc8inx 4099 15 subjected subject VBN cord-010092-uftc8inx 4099 16 to to IN cord-010092-uftc8inx 4099 17 pretransfusion pretransfusion NNP cord-010092-uftc8inx 4099 18 test test NN cord-010092-uftc8inx 4099 19 . . . cord-010092-uftc8inx 4100 1 This this DT cord-010092-uftc8inx 4100 2 showed show VBD cord-010092-uftc8inx 4100 3 savings saving NNS cord-010092-uftc8inx 4100 4 of of IN cord-010092-uftc8inx 4100 5 1,098,300,000 1,098,300,000 CD cord-010092-uftc8inx 4100 6 Rupiah Rupiah NNP cord-010092-uftc8inx 4100 7 . . . cord-010092-uftc8inx 4101 1 C C NNP cord-010092-uftc8inx 4101 2 / / SYM cord-010092-uftc8inx 4101 3 T t NN cord-010092-uftc8inx 4101 4 ratio ratio NN cord-010092-uftc8inx 4101 5 was be VBD cord-010092-uftc8inx 4101 6 1.6 1.6 CD cord-010092-uftc8inx 4101 7 which which WDT cord-010092-uftc8inx 4101 8 demonstrate demonstrate VBP cord-010092-uftc8inx 4101 9 a a DT cord-010092-uftc8inx 4101 10 good good JJ cord-010092-uftc8inx 4101 11 ordering ordering NN cord-010092-uftc8inx 4101 12 pattern pattern NN cord-010092-uftc8inx 4101 13 . . . cord-010092-uftc8inx 4102 1 However however RB cord-010092-uftc8inx 4102 2 , , , cord-010092-uftc8inx 4102 3 16.4 16.4 CD cord-010092-uftc8inx 4102 4 % % NN cord-010092-uftc8inx 4102 5 ( ( -LRB- cord-010092-uftc8inx 4102 6 27,451 27,451 CD cord-010092-uftc8inx 4102 7 ) ) -RRB- cord-010092-uftc8inx 4102 8 of of IN cord-010092-uftc8inx 4102 9 completed complete VBN cord-010092-uftc8inx 4102 10 pretransfusion pretransfusion NN cord-010092-uftc8inx 4102 11 testing testing NN cord-010092-uftc8inx 4102 12 of of IN cord-010092-uftc8inx 4102 13 ordering order VBG cord-010092-uftc8inx 4102 14 PRC PRC NNP cord-010092-uftc8inx 4102 15 unit unit NN cord-010092-uftc8inx 4102 16 were be VBD cord-010092-uftc8inx 4102 17 not not RB cord-010092-uftc8inx 4102 18 transfused transfuse VBN cord-010092-uftc8inx 4102 19 , , , cord-010092-uftc8inx 4102 20 leading lead VBG cord-010092-uftc8inx 4102 21 to to IN cord-010092-uftc8inx 4102 22 blood blood NN cord-010092-uftc8inx 4102 23 bank bank NN cord-010092-uftc8inx 4102 24 loss loss NN cord-010092-uftc8inx 4102 25 of of IN cord-010092-uftc8inx 4102 26 2,882,355,000 2,882,355,000 CD cord-010092-uftc8inx 4102 27 Rupiah Rupiah NNP cord-010092-uftc8inx 4102 28 . . . cord-010092-uftc8inx 4103 1 Summary Summary NNP cord-010092-uftc8inx 4103 2 / / SYM cord-010092-uftc8inx 4103 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 4103 4 : : : cord-010092-uftc8inx 4104 1 Strategies strategy NNS cord-010092-uftc8inx 4104 2 for for IN cord-010092-uftc8inx 4104 3 limiting limit VBG cord-010092-uftc8inx 4104 4 the the DT cord-010092-uftc8inx 4104 5 number number NN cord-010092-uftc8inx 4104 6 of of IN cord-010092-uftc8inx 4104 7 pretransfusion pretransfusion NN cord-010092-uftc8inx 4104 8 testing testing NN cord-010092-uftc8inx 4104 9 on on IN cord-010092-uftc8inx 4104 10 the the DT cord-010092-uftc8inx 4104 11 good good JJ cord-010092-uftc8inx 4104 12 C C NNP cord-010092-uftc8inx 4104 13 / / SYM cord-010092-uftc8inx 4104 14 T t NN cord-010092-uftc8inx 4104 15 ratio ratio NN cord-010092-uftc8inx 4104 16 was be VBD cord-010092-uftc8inx 4104 17 still still RB cord-010092-uftc8inx 4104 18 associated associate VBN cord-010092-uftc8inx 4104 19 with with IN cord-010092-uftc8inx 4104 20 saving save VBG cord-010092-uftc8inx 4104 21 cost cost NN cord-010092-uftc8inx 4104 22 effective effective JJ cord-010092-uftc8inx 4104 23 Background background NN cord-010092-uftc8inx 4104 24 : : : cord-010092-uftc8inx 4104 25 Blood blood NN cord-010092-uftc8inx 4104 26 is be VBZ cord-010092-uftc8inx 4104 27 a a DT cord-010092-uftc8inx 4104 28 precious precious JJ cord-010092-uftc8inx 4104 29 resource resource NN cord-010092-uftc8inx 4104 30 for for IN cord-010092-uftc8inx 4104 31 saving save VBG cord-010092-uftc8inx 4104 32 patient patient NN cord-010092-uftc8inx 4104 33 lives life NNS cord-010092-uftc8inx 4104 34 . . . cord-010092-uftc8inx 4105 1 The the DT cord-010092-uftc8inx 4105 2 purpose purpose NN cord-010092-uftc8inx 4105 3 of of IN cord-010092-uftc8inx 4105 4 blood blood NN cord-010092-uftc8inx 4105 5 and and CC cord-010092-uftc8inx 4105 6 blood blood NN cord-010092-uftc8inx 4105 7 component component NN cord-010092-uftc8inx 4105 8 therapy therapy NN cord-010092-uftc8inx 4105 9 is be VBZ cord-010092-uftc8inx 4105 10 to to TO cord-010092-uftc8inx 4105 11 provide provide VB cord-010092-uftc8inx 4105 12 suitable suitable JJ cord-010092-uftc8inx 4105 13 and and CC cord-010092-uftc8inx 4105 14 safe safe JJ cord-010092-uftc8inx 4105 15 blood blood NN cord-010092-uftc8inx 4105 16 products product NNS cord-010092-uftc8inx 4105 17 to to TO cord-010092-uftc8inx 4105 18 achieve achieve VB cord-010092-uftc8inx 4105 19 best good JJS cord-010092-uftc8inx 4105 20 clinical clinical JJ cord-010092-uftc8inx 4105 21 outcomes outcome NNS cord-010092-uftc8inx 4105 22 . . . cord-010092-uftc8inx 4106 1 Nurses nurse NNS cord-010092-uftc8inx 4106 2 have have VBP cord-010092-uftc8inx 4106 3 an an DT cord-010092-uftc8inx 4106 4 important important JJ cord-010092-uftc8inx 4106 5 role role NN cord-010092-uftc8inx 4106 6 in in IN cord-010092-uftc8inx 4106 7 ensuring ensure VBG cord-010092-uftc8inx 4106 8 safe safe JJ cord-010092-uftc8inx 4106 9 blood blood NN cord-010092-uftc8inx 4106 10 transfusion transfusion NN cord-010092-uftc8inx 4106 11 . . . cord-010092-uftc8inx 4107 1 It -PRON- PRP cord-010092-uftc8inx 4107 2 is be VBZ cord-010092-uftc8inx 4107 3 crucial crucial JJ cord-010092-uftc8inx 4107 4 for for IN cord-010092-uftc8inx 4107 5 nurses nurse NNS cord-010092-uftc8inx 4107 6 to to TO cord-010092-uftc8inx 4107 7 have have VB cord-010092-uftc8inx 4107 8 sufficient sufficient JJ cord-010092-uftc8inx 4107 9 knowledge knowledge NN cord-010092-uftc8inx 4107 10 about about IN cord-010092-uftc8inx 4107 11 blood blood NN cord-010092-uftc8inx 4107 12 donation donation NN cord-010092-uftc8inx 4107 13 and and CC cord-010092-uftc8inx 4107 14 collection collection NN cord-010092-uftc8inx 4107 15 , , , cord-010092-uftc8inx 4107 16 storage storage NN cord-010092-uftc8inx 4107 17 , , , cord-010092-uftc8inx 4107 18 component component NN cord-010092-uftc8inx 4107 19 preparation preparation NN cord-010092-uftc8inx 4107 20 , , , cord-010092-uftc8inx 4107 21 possible possible JJ cord-010092-uftc8inx 4107 22 adverse adverse JJ cord-010092-uftc8inx 4107 23 effects effect NNS cord-010092-uftc8inx 4107 24 of of IN cord-010092-uftc8inx 4107 25 blood blood NN cord-010092-uftc8inx 4107 26 transfusion transfusion NN cord-010092-uftc8inx 4107 27 and and CC cord-010092-uftc8inx 4107 28 necessary necessary JJ cord-010092-uftc8inx 4107 29 management management NN cord-010092-uftc8inx 4107 30 and and CC cord-010092-uftc8inx 4107 31 care care NN cord-010092-uftc8inx 4107 32 . . . cord-010092-uftc8inx 4108 1 Aims aim VBZ cord-010092-uftc8inx 4108 2 : : : cord-010092-uftc8inx 4109 1 The the DT cord-010092-uftc8inx 4109 2 aim aim NN cord-010092-uftc8inx 4109 3 of of IN cord-010092-uftc8inx 4109 4 this this DT cord-010092-uftc8inx 4109 5 study study NN cord-010092-uftc8inx 4109 6 was be VBD cord-010092-uftc8inx 4109 7 to to TO cord-010092-uftc8inx 4109 8 assess assess VB cord-010092-uftc8inx 4109 9 the the DT cord-010092-uftc8inx 4109 10 impact impact NN cord-010092-uftc8inx 4109 11 of of IN cord-010092-uftc8inx 4109 12 an an DT cord-010092-uftc8inx 4109 13 educational educational JJ cord-010092-uftc8inx 4109 14 intervention intervention NN cord-010092-uftc8inx 4109 15 on on IN cord-010092-uftc8inx 4109 16 knowledge knowledge NN cord-010092-uftc8inx 4109 17 and and CC cord-010092-uftc8inx 4109 18 awareness awareness NN cord-010092-uftc8inx 4109 19 of of IN cord-010092-uftc8inx 4109 20 nurses nurse NNS cord-010092-uftc8inx 4109 21 regarding regard VBG cord-010092-uftc8inx 4109 22 blood blood NN cord-010092-uftc8inx 4109 23 transfusion transfusion NN cord-010092-uftc8inx 4109 24 services service NNS cord-010092-uftc8inx 4109 25 and and CC cord-010092-uftc8inx 4109 26 practices practice NNS cord-010092-uftc8inx 4109 27 . . . cord-010092-uftc8inx 4110 1 Methods method NNS cord-010092-uftc8inx 4110 2 : : : cord-010092-uftc8inx 4110 3 The the DT cord-010092-uftc8inx 4110 4 baseline baseline JJ cord-010092-uftc8inx 4110 5 study study NN cord-010092-uftc8inx 4110 6 to to TO cord-010092-uftc8inx 4110 7 assess assess VB cord-010092-uftc8inx 4110 8 the the DT cord-010092-uftc8inx 4110 9 knowledge knowledge NN cord-010092-uftc8inx 4110 10 and and CC cord-010092-uftc8inx 4110 11 awareness awareness NN cord-010092-uftc8inx 4110 12 regarding regard VBG cord-010092-uftc8inx 4110 13 blood blood NN cord-010092-uftc8inx 4110 14 transfusion transfusion NN cord-010092-uftc8inx 4110 15 services service NNS cord-010092-uftc8inx 4110 16 and and CC cord-010092-uftc8inx 4110 17 practices practice NNS cord-010092-uftc8inx 4110 18 of of IN cord-010092-uftc8inx 4110 19 the the DT cord-010092-uftc8inx 4110 20 nurses nurse NNS cord-010092-uftc8inx 4110 21 posted post VBN cord-010092-uftc8inx 4110 22 at at IN cord-010092-uftc8inx 4110 23 various various JJ cord-010092-uftc8inx 4110 24 areas area NNS cord-010092-uftc8inx 4110 25 of of IN cord-010092-uftc8inx 4110 26 the the DT cord-010092-uftc8inx 4110 27 hospital hospital NN cord-010092-uftc8inx 4110 28 including include VBG cord-010092-uftc8inx 4110 29 wards ward NNS cord-010092-uftc8inx 4110 30 , , , cord-010092-uftc8inx 4110 31 operation operation NN cord-010092-uftc8inx 4110 32 theatres theatre NNS cord-010092-uftc8inx 4110 33 and and CC cord-010092-uftc8inx 4110 34 critical critical JJ cord-010092-uftc8inx 4110 35 care care NN cord-010092-uftc8inx 4110 36 areas area NNS cord-010092-uftc8inx 4110 37 was be VBD cord-010092-uftc8inx 4110 38 carried carry VBN cord-010092-uftc8inx 4110 39 out out RP cord-010092-uftc8inx 4110 40 at at IN cord-010092-uftc8inx 4110 41 our -PRON- PRP$ cord-010092-uftc8inx 4110 42 institute institute NN cord-010092-uftc8inx 4110 43 hospital hospital NN cord-010092-uftc8inx 4110 44 which which WDT cord-010092-uftc8inx 4110 45 is be VBZ cord-010092-uftc8inx 4110 46 a a DT cord-010092-uftc8inx 4110 47 tertiary tertiary JJ cord-010092-uftc8inx 4110 48 care care NN cord-010092-uftc8inx 4110 49 teaching teaching NN cord-010092-uftc8inx 4110 50 centre centre NN cord-010092-uftc8inx 4110 51 . . . cord-010092-uftc8inx 4111 1 The the DT cord-010092-uftc8inx 4111 2 nurses nurse NNS cord-010092-uftc8inx 4111 3 were be VBD cord-010092-uftc8inx 4111 4 then then RB cord-010092-uftc8inx 4111 5 sensitized sensitize VBN cord-010092-uftc8inx 4111 6 and and CC cord-010092-uftc8inx 4111 7 educated educate VBN cord-010092-uftc8inx 4111 8 regarding regard VBG cord-010092-uftc8inx 4111 9 blood blood NN cord-010092-uftc8inx 4111 10 transfusion transfusion NN cord-010092-uftc8inx 4111 11 services service NNS cord-010092-uftc8inx 4111 12 and and CC cord-010092-uftc8inx 4111 13 practices practice NNS cord-010092-uftc8inx 4111 14 during during IN cord-010092-uftc8inx 4111 15 their -PRON- PRP$ cord-010092-uftc8inx 4111 16 day day NN cord-010092-uftc8inx 4111 17 to to IN cord-010092-uftc8inx 4111 18 day day NN cord-010092-uftc8inx 4111 19 activities activity NNS cord-010092-uftc8inx 4111 20 by by IN cord-010092-uftc8inx 4111 21 referring refer VBG cord-010092-uftc8inx 4111 22 them -PRON- PRP cord-010092-uftc8inx 4111 23 to to IN cord-010092-uftc8inx 4111 24 the the DT cord-010092-uftc8inx 4111 25 blood blood NN cord-010092-uftc8inx 4111 26 transfusion transfusion NN cord-010092-uftc8inx 4111 27 guidelines guideline NNS cord-010092-uftc8inx 4111 28 of of IN cord-010092-uftc8inx 4111 29 the the DT cord-010092-uftc8inx 4111 30 institute institute NN cord-010092-uftc8inx 4111 31 . . . cord-010092-uftc8inx 4112 1 Subsequently subsequently RB cord-010092-uftc8inx 4112 2 , , , cord-010092-uftc8inx 4112 3 a a DT cord-010092-uftc8inx 4112 4 self self NN cord-010092-uftc8inx 4112 5 - - HYPH cord-010092-uftc8inx 4112 6 developed develop VBN cord-010092-uftc8inx 4112 7 questionnaire questionnaire NN cord-010092-uftc8inx 4112 8 which which WDT cord-010092-uftc8inx 4112 9 was be VBD cord-010092-uftc8inx 4112 10 used use VBN cord-010092-uftc8inx 4112 11 for for IN cord-010092-uftc8inx 4112 12 the the DT cord-010092-uftc8inx 4112 13 baseline baseline JJ cord-010092-uftc8inx 4112 14 assessment assessment NN cord-010092-uftc8inx 4112 15 of of IN cord-010092-uftc8inx 4112 16 knowledge knowledge NN cord-010092-uftc8inx 4112 17 and and CC cord-010092-uftc8inx 4112 18 awareness awareness NN cord-010092-uftc8inx 4112 19 of of IN cord-010092-uftc8inx 4112 20 the the DT cord-010092-uftc8inx 4112 21 nurses nurse NNS cord-010092-uftc8inx 4112 22 was be VBD cord-010092-uftc8inx 4112 23 again again RB cord-010092-uftc8inx 4112 24 used use VBN cord-010092-uftc8inx 4112 25 to to TO cord-010092-uftc8inx 4112 26 reassess reassess VB cord-010092-uftc8inx 4112 27 them -PRON- PRP cord-010092-uftc8inx 4112 28 . . . cord-010092-uftc8inx 4113 1 A a DT cord-010092-uftc8inx 4113 2 total total NN cord-010092-uftc8inx 4113 3 of of IN cord-010092-uftc8inx 4113 4 19 19 CD cord-010092-uftc8inx 4113 5 questions question NNS cord-010092-uftc8inx 4113 6 were be VBD cord-010092-uftc8inx 4113 7 included include VBN cord-010092-uftc8inx 4113 8 in in IN cord-010092-uftc8inx 4113 9 the the DT cord-010092-uftc8inx 4113 10 questionnaire questionnaire NN cord-010092-uftc8inx 4113 11 pertaining pertain VBG cord-010092-uftc8inx 4113 12 to to IN cord-010092-uftc8inx 4113 13 : : : cord-010092-uftc8inx 4113 14 general general JJ cord-010092-uftc8inx 4113 15 awareness awareness NN cord-010092-uftc8inx 4113 16 ( ( -LRB- cord-010092-uftc8inx 4113 17 two two CD cord-010092-uftc8inx 4113 18 questions question NNS cord-010092-uftc8inx 4113 19 ) ) -RRB- cord-010092-uftc8inx 4113 20 , , , cord-010092-uftc8inx 4113 21 blood blood NN cord-010092-uftc8inx 4113 22 donation donation NN cord-010092-uftc8inx 4113 23 ( ( -LRB- cord-010092-uftc8inx 4113 24 two two CD cord-010092-uftc8inx 4113 25 questions question NNS cord-010092-uftc8inx 4113 26 ) ) -RRB- cord-010092-uftc8inx 4113 27 , , , cord-010092-uftc8inx 4113 28 testing testing NN cord-010092-uftc8inx 4113 29 and and CC cord-010092-uftc8inx 4113 30 blood blood NN cord-010092-uftc8inx 4113 31 component component NN cord-010092-uftc8inx 4113 32 preparation preparation NN cord-010092-uftc8inx 4113 33 related relate VBN cord-010092-uftc8inx 4113 34 ( ( -LRB- cord-010092-uftc8inx 4113 35 two two CD cord-010092-uftc8inx 4113 36 questions question NNS cord-010092-uftc8inx 4113 37 ) ) -RRB- cord-010092-uftc8inx 4113 38 , , , cord-010092-uftc8inx 4113 39 storage storage NN cord-010092-uftc8inx 4113 40 of of IN cord-010092-uftc8inx 4113 41 blood blood NN cord-010092-uftc8inx 4113 42 / / SYM cord-010092-uftc8inx 4113 43 blood blood NN cord-010092-uftc8inx 4113 44 components component NNS cord-010092-uftc8inx 4113 45 ( ( -LRB- cord-010092-uftc8inx 4113 46 two two CD cord-010092-uftc8inx 4113 47 questions question NNS cord-010092-uftc8inx 4113 48 ) ) -RRB- cord-010092-uftc8inx 4113 49 and and CC cord-010092-uftc8inx 4113 50 pre pre JJ cord-010092-uftc8inx 4113 51 - - JJ cord-010092-uftc8inx 4113 52 transfusion transfusion JJ cord-010092-uftc8inx 4113 53 checks check NNS cord-010092-uftc8inx 4113 54 and and CC cord-010092-uftc8inx 4113 55 bed bed NN cord-010092-uftc8inx 4113 56 side side JJ cord-010092-uftc8inx 4113 57 transfusion transfusion NN cord-010092-uftc8inx 4113 58 practices practice NNS cord-010092-uftc8inx 4113 59 ( ( -LRB- cord-010092-uftc8inx 4113 60 eleven eleven CD cord-010092-uftc8inx 4113 61 questions question NNS cord-010092-uftc8inx 4113 62 ) ) -RRB- cord-010092-uftc8inx 4113 63 . . . cord-010092-uftc8inx 4114 1 Fifty fifty CD cord-010092-uftc8inx 4114 2 nurses nurse NNS cord-010092-uftc8inx 4114 3 each each DT cord-010092-uftc8inx 4114 4 were be VBD cord-010092-uftc8inx 4114 5 included include VBN cord-010092-uftc8inx 4114 6 for for IN cord-010092-uftc8inx 4114 7 both both CC cord-010092-uftc8inx 4114 8 the the DT cord-010092-uftc8inx 4114 9 baseline baseline NN cord-010092-uftc8inx 4114 10 as as RB cord-010092-uftc8inx 4114 11 well well RB cord-010092-uftc8inx 4114 12 as as IN cord-010092-uftc8inx 4114 13 post post JJ cord-010092-uftc8inx 4114 14 - - JJ cord-010092-uftc8inx 4114 15 sensitization sensitization JJ cord-010092-uftc8inx 4114 16 assessment assessment NN cord-010092-uftc8inx 4114 17 . . . cord-010092-uftc8inx 4115 1 For for IN cord-010092-uftc8inx 4115 2 different different JJ cord-010092-uftc8inx 4115 3 category category NN cord-010092-uftc8inx 4115 4 of of IN cord-010092-uftc8inx 4115 5 questions question NNS cord-010092-uftc8inx 4115 6 , , , cord-010092-uftc8inx 4115 7 the the DT cord-010092-uftc8inx 4115 8 correct correct JJ cord-010092-uftc8inx 4115 9 response response NN cord-010092-uftc8inx 4115 10 rates rate NNS cord-010092-uftc8inx 4115 11 were be VBD cord-010092-uftc8inx 4115 12 compared compare VBN cord-010092-uftc8inx 4115 13 with with IN cord-010092-uftc8inx 4115 14 those those DT cord-010092-uftc8inx 4115 15 obtained obtain VBN cord-010092-uftc8inx 4115 16 in in IN cord-010092-uftc8inx 4115 17 the the DT cord-010092-uftc8inx 4115 18 baseline baseline JJ cord-010092-uftc8inx 4115 19 study study NN cord-010092-uftc8inx 4115 20 using use VBG cord-010092-uftc8inx 4115 21 Mann Mann NNP cord-010092-uftc8inx 4115 22 - - HYPH cord-010092-uftc8inx 4115 23 Whitney Whitney NNP cord-010092-uftc8inx 4115 24 test test NN cord-010092-uftc8inx 4115 25 . . . cord-010092-uftc8inx 4116 1 The the DT cord-010092-uftc8inx 4116 2 entire entire JJ cord-010092-uftc8inx 4116 3 study study NN cord-010092-uftc8inx 4116 4 duration duration NN cord-010092-uftc8inx 4116 5 was be VBD cord-010092-uftc8inx 4116 6 spread spread VBN cord-010092-uftc8inx 4116 7 over over IN cord-010092-uftc8inx 4116 8 a a DT cord-010092-uftc8inx 4116 9 period period NN cord-010092-uftc8inx 4116 10 of of IN cord-010092-uftc8inx 4116 11 three three CD cord-010092-uftc8inx 4116 12 months month NNS cord-010092-uftc8inx 4116 13 ( ( -LRB- cord-010092-uftc8inx 4116 14 December December NNP cord-010092-uftc8inx 4116 15 , , , cord-010092-uftc8inx 4116 16 2014 2014 CD cord-010092-uftc8inx 4116 17 to to IN cord-010092-uftc8inx 4116 18 February February NNP cord-010092-uftc8inx 4116 19 , , , cord-010092-uftc8inx 4116 20 2015 2015 CD cord-010092-uftc8inx 4116 21 . . . cord-010092-uftc8inx 4117 1 Results result NNS cord-010092-uftc8inx 4117 2 : : : cord-010092-uftc8inx 4118 1 The the DT cord-010092-uftc8inx 4118 2 overall overall JJ cord-010092-uftc8inx 4118 3 mean mean JJ cord-010092-uftc8inx 4118 4 percentage percentage NN cord-010092-uftc8inx 4118 5 of of IN cord-010092-uftc8inx 4118 6 ' ' `` cord-010092-uftc8inx 4118 7 correct correct JJ cord-010092-uftc8inx 4118 8 ' ' '' cord-010092-uftc8inx 4118 9 responses response NNS cord-010092-uftc8inx 4118 10 for for IN cord-010092-uftc8inx 4118 11 19 19 CD cord-010092-uftc8inx 4118 12 questions question NNS cord-010092-uftc8inx 4118 13 in in IN cord-010092-uftc8inx 4118 14 the the DT cord-010092-uftc8inx 4118 15 baseline baseline JJ cord-010092-uftc8inx 4118 16 study study NN cord-010092-uftc8inx 4118 17 was be VBD cord-010092-uftc8inx 4118 18 61.75 61.75 CD cord-010092-uftc8inx 4118 19 % % NN cord-010092-uftc8inx 4118 20 , , , cord-010092-uftc8inx 4118 21 whereas whereas IN cord-010092-uftc8inx 4118 22 post post NN cord-010092-uftc8inx 4118 23 sensitization sensitization NN cord-010092-uftc8inx 4118 24 it -PRON- PRP cord-010092-uftc8inx 4118 25 was be VBD cord-010092-uftc8inx 4118 26 77.21 77.21 CD cord-010092-uftc8inx 4118 27 % % NN cord-010092-uftc8inx 4118 28 . . . cord-010092-uftc8inx 4119 1 The the DT cord-010092-uftc8inx 4119 2 mean mean JJ cord-010092-uftc8inx 4119 3 percentage percentage NN cord-010092-uftc8inx 4119 4 increase increase NN cord-010092-uftc8inx 4119 5 in in IN cord-010092-uftc8inx 4119 6 general general JJ cord-010092-uftc8inx 4119 7 awareness awareness NN cord-010092-uftc8inx 4119 8 related relate VBN cord-010092-uftc8inx 4119 9 questions question NNS cord-010092-uftc8inx 4119 10 was be VBD cord-010092-uftc8inx 4119 11 21.49 21.49 CD cord-010092-uftc8inx 4119 12 % % NN cord-010092-uftc8inx 4119 13 , , , cord-010092-uftc8inx 4119 14 13.95 13.95 CD cord-010092-uftc8inx 4119 15 % % NN cord-010092-uftc8inx 4119 16 for for IN cord-010092-uftc8inx 4119 17 storage storage NN cord-010092-uftc8inx 4119 18 of of IN cord-010092-uftc8inx 4119 19 blood blood NN cord-010092-uftc8inx 4119 20 / / SYM cord-010092-uftc8inx 4119 21 blood blood NN cord-010092-uftc8inx 4119 22 components component NNS cord-010092-uftc8inx 4119 23 related relate VBN cord-010092-uftc8inx 4119 24 questions question NNS cord-010092-uftc8inx 4119 25 , , , cord-010092-uftc8inx 4119 26 17.37 17.37 CD cord-010092-uftc8inx 4119 27 % % NN cord-010092-uftc8inx 4119 28 for for IN cord-010092-uftc8inx 4119 29 pre pre JJ cord-010092-uftc8inx 4119 30 - - JJ cord-010092-uftc8inx 4119 31 transfusion transfusion JJ cord-010092-uftc8inx 4119 32 checks check NNS cord-010092-uftc8inx 4119 33 and and CC cord-010092-uftc8inx 4119 34 bedside bedside NN cord-010092-uftc8inx 4119 35 transfusion transfusion NN cord-010092-uftc8inx 4119 36 practices practice NNS cord-010092-uftc8inx 4119 37 related relate VBN cord-010092-uftc8inx 4119 38 questions question NNS cord-010092-uftc8inx 4119 39 , , , cord-010092-uftc8inx 4119 40 21.33 21.33 CD cord-010092-uftc8inx 4119 41 % % NN cord-010092-uftc8inx 4119 42 for for IN cord-010092-uftc8inx 4119 43 testing testing NN cord-010092-uftc8inx 4119 44 and and CC cord-010092-uftc8inx 4119 45 blood blood NN cord-010092-uftc8inx 4119 46 component component NN cord-010092-uftc8inx 4119 47 preparation preparation NN cord-010092-uftc8inx 4119 48 related relate VBN cord-010092-uftc8inx 4119 49 questions question NNS cord-010092-uftc8inx 4119 50 and and CC cord-010092-uftc8inx 4119 51 27.27 27.27 CD cord-010092-uftc8inx 4119 52 % % NN cord-010092-uftc8inx 4119 53 for for IN cord-010092-uftc8inx 4119 54 blood blood NN cord-010092-uftc8inx 4119 55 donation donation NN cord-010092-uftc8inx 4119 56 related relate VBN cord-010092-uftc8inx 4119 57 questions question NNS cord-010092-uftc8inx 4119 58 . . . cord-010092-uftc8inx 4120 1 The the DT cord-010092-uftc8inx 4120 2 percentage percentage NN cord-010092-uftc8inx 4120 3 increase increase NN cord-010092-uftc8inx 4120 4 in in IN cord-010092-uftc8inx 4120 5 correct correct JJ cord-010092-uftc8inx 4120 6 response response NN cord-010092-uftc8inx 4120 7 was be VBD cord-010092-uftc8inx 4120 8 found find VBN cord-010092-uftc8inx 4120 9 to to TO cord-010092-uftc8inx 4120 10 be be VB cord-010092-uftc8inx 4120 11 statically statically RB cord-010092-uftc8inx 4120 12 significant significant JJ cord-010092-uftc8inx 4120 13 for for IN cord-010092-uftc8inx 4120 14 each each DT cord-010092-uftc8inx 4120 15 of of IN cord-010092-uftc8inx 4120 16 the the DT cord-010092-uftc8inx 4120 17 five five CD cord-010092-uftc8inx 4120 18 categories category NNS cord-010092-uftc8inx 4120 19 of of IN cord-010092-uftc8inx 4120 20 questions question NNS cord-010092-uftc8inx 4120 21 . . . cord-010092-uftc8inx 4121 1 The the DT cord-010092-uftc8inx 4121 2 overall overall JJ cord-010092-uftc8inx 4121 3 mean mean JJ cord-010092-uftc8inx 4121 4 percentage percentage NN cord-010092-uftc8inx 4121 5 increase increase NN cord-010092-uftc8inx 4121 6 in in IN cord-010092-uftc8inx 4121 7 correct correct JJ cord-010092-uftc8inx 4121 8 response response NN cord-010092-uftc8inx 4121 9 rate rate NN cord-010092-uftc8inx 4121 10 was be VBD cord-010092-uftc8inx 4121 11 also also RB cord-010092-uftc8inx 4121 12 statistically statistically RB cord-010092-uftc8inx 4121 13 significant significant JJ cord-010092-uftc8inx 4121 14 ( ( -LRB- cord-010092-uftc8inx 4121 15 P p NN cord-010092-uftc8inx 4121 16 < < XX cord-010092-uftc8inx 4121 17 0.001 0.001 CD cord-010092-uftc8inx 4121 18 ) ) -RRB- cord-010092-uftc8inx 4121 19 . . . cord-010092-uftc8inx 4122 1 Summary Summary NNP cord-010092-uftc8inx 4122 2 / / SYM cord-010092-uftc8inx 4122 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 4122 4 : : : cord-010092-uftc8inx 4123 1 This this DT cord-010092-uftc8inx 4123 2 study study NN cord-010092-uftc8inx 4123 3 revealed reveal VBD cord-010092-uftc8inx 4123 4 that that IN cord-010092-uftc8inx 4123 5 after after IN cord-010092-uftc8inx 4123 6 sensitization sensitization NN cord-010092-uftc8inx 4123 7 and and CC cord-010092-uftc8inx 4123 8 educational educational JJ cord-010092-uftc8inx 4123 9 intervention intervention NN cord-010092-uftc8inx 4123 10 there there EX cord-010092-uftc8inx 4123 11 was be VBD cord-010092-uftc8inx 4123 12 a a DT cord-010092-uftc8inx 4123 13 significant significant JJ cord-010092-uftc8inx 4123 14 improvement improvement NN cord-010092-uftc8inx 4123 15 in in IN cord-010092-uftc8inx 4123 16 the the DT cord-010092-uftc8inx 4123 17 knowledge knowledge NN cord-010092-uftc8inx 4123 18 and and CC cord-010092-uftc8inx 4123 19 awareness awareness NN cord-010092-uftc8inx 4123 20 of of IN cord-010092-uftc8inx 4123 21 nurses nurse NNS cord-010092-uftc8inx 4123 22 regarding regard VBG cord-010092-uftc8inx 4123 23 the the DT cord-010092-uftc8inx 4123 24 blood blood NN cord-010092-uftc8inx 4123 25 transfusion transfusion NN cord-010092-uftc8inx 4123 26 services service NNS cord-010092-uftc8inx 4123 27 and and CC cord-010092-uftc8inx 4123 28 practices practice NNS cord-010092-uftc8inx 4123 29 . . . cord-010092-uftc8inx 4124 1 Abstract Abstract NNP cord-010092-uftc8inx 4124 2 withdrawn withdraw VBN cord-010092-uftc8inx 4124 3 . . . cord-010092-uftc8inx 4125 1 Background background NN cord-010092-uftc8inx 4125 2 : : : cord-010092-uftc8inx 4126 1 TACT tact NN cord-010092-uftc8inx 4126 2 , , , cord-010092-uftc8inx 4126 3 introduced introduce VBN cord-010092-uftc8inx 4126 4 in in IN cord-010092-uftc8inx 4126 5 the the DT cord-010092-uftc8inx 4126 6 UK UK NNP cord-010092-uftc8inx 4126 7 in in IN cord-010092-uftc8inx 4126 8 2014 2014 CD cord-010092-uftc8inx 4126 9 to to TO cord-010092-uftc8inx 4126 10 support support VB cord-010092-uftc8inx 4126 11 managers manager NNS cord-010092-uftc8inx 4126 12 , , , cord-010092-uftc8inx 4126 13 provides provide VBZ cord-010092-uftc8inx 4126 14 resource resource NN cord-010092-uftc8inx 4126 15 - - HYPH cord-010092-uftc8inx 4126 16 saving save VBG cord-010092-uftc8inx 4126 17 , , , cord-010092-uftc8inx 4126 18 continual continual JJ cord-010092-uftc8inx 4126 19 , , , cord-010092-uftc8inx 4126 20 ' ' '' cord-010092-uftc8inx 4126 21 real real JJ cord-010092-uftc8inx 4126 22 - - HYPH cord-010092-uftc8inx 4126 23 time time NN cord-010092-uftc8inx 4126 24 ' ' '' cord-010092-uftc8inx 4126 25 monitoring monitoring NN cord-010092-uftc8inx 4126 26 of of IN cord-010092-uftc8inx 4126 27 knowledge knowledge NN cord-010092-uftc8inx 4126 28 - - HYPH cord-010092-uftc8inx 4126 29 based base VBN cord-010092-uftc8inx 4126 30 competency competency NN cord-010092-uftc8inx 4126 31 of of IN cord-010092-uftc8inx 4126 32 staff staff NN cord-010092-uftc8inx 4126 33 in in IN cord-010092-uftc8inx 4126 34 transfusion transfusion NN cord-010092-uftc8inx 4126 35 laboratories laboratory NNS cord-010092-uftc8inx 4126 36 . . . cord-010092-uftc8inx 4127 1 TACT tact NN cord-010092-uftc8inx 4127 2 is be VBZ cord-010092-uftc8inx 4127 3 available available JJ cord-010092-uftc8inx 4127 4 online online RB cord-010092-uftc8inx 4127 5 24/7 24/7 RB cord-010092-uftc8inx 4127 6 , , , cord-010092-uftc8inx 4127 7 complementing complement VBG cord-010092-uftc8inx 4127 8 existing exist VBG cord-010092-uftc8inx 4127 9 practical practical JJ cord-010092-uftc8inx 4127 10 competency competency NN cord-010092-uftc8inx 4127 11 schemes scheme NNS cord-010092-uftc8inx 4127 12 and and CC cord-010092-uftc8inx 4127 13 external external JJ cord-010092-uftc8inx 4127 14 quality quality NN cord-010092-uftc8inx 4127 15 assessment assessment NN cord-010092-uftc8inx 4127 16 . . . cord-010092-uftc8inx 4128 1 Multiple multiple JJ cord-010092-uftc8inx 4128 2 variations variation NNS cord-010092-uftc8inx 4128 3 on on IN cord-010092-uftc8inx 4128 4 a a DT cord-010092-uftc8inx 4128 5 standard standard JJ cord-010092-uftc8inx 4128 6 pre pre JJ cord-010092-uftc8inx 4128 7 - - JJ cord-010092-uftc8inx 4128 8 transfusion transfusion JJ cord-010092-uftc8inx 4128 9 testing testing NN cord-010092-uftc8inx 4128 10 scenario scenario NN cord-010092-uftc8inx 4128 11 are be VBP cord-010092-uftc8inx 4128 12 generated generate VBN cord-010092-uftc8inx 4128 13 using use VBG cord-010092-uftc8inx 4128 14 constrained constrained JJ cord-010092-uftc8inx 4128 15 randomisation randomisation NN cord-010092-uftc8inx 4128 16 ; ; : cord-010092-uftc8inx 4128 17 logic logic NN cord-010092-uftc8inx 4128 18 rules rule NNS cord-010092-uftc8inx 4128 19 for for IN cord-010092-uftc8inx 4128 20 automatic automatic JJ cord-010092-uftc8inx 4128 21 assessment assessment NN cord-010092-uftc8inx 4128 22 of of IN cord-010092-uftc8inx 4128 23 sample sample NN cord-010092-uftc8inx 4128 24 acceptance acceptance NN cord-010092-uftc8inx 4128 25 , , , cord-010092-uftc8inx 4128 26 ABO ABO NNP cord-010092-uftc8inx 4128 27 / / SYM cord-010092-uftc8inx 4128 28 D D NNP cord-010092-uftc8inx 4128 29 , , , cord-010092-uftc8inx 4128 30 antibody antibody NN cord-010092-uftc8inx 4128 31 screen screen NN cord-010092-uftc8inx 4128 32 and and CC cord-010092-uftc8inx 4128 33 identification identification NN cord-010092-uftc8inx 4128 34 ( ( -LRB- cord-010092-uftc8inx 4128 35 AS AS NNP cord-010092-uftc8inx 4128 36 / / SYM cord-010092-uftc8inx 4128 37 ID ID NNP cord-010092-uftc8inx 4128 38 ) ) -RRB- cord-010092-uftc8inx 4128 39 , , , cord-010092-uftc8inx 4128 40 and and CC cord-010092-uftc8inx 4128 41 component component NN cord-010092-uftc8inx 4128 42 issue issue NN cord-010092-uftc8inx 4128 43 are be VBP cord-010092-uftc8inx 4128 44 based base VBN cord-010092-uftc8inx 4128 45 on on IN cord-010092-uftc8inx 4128 46 BSH BSH NNP cord-010092-uftc8inx 4128 47 guidance guidance NN cord-010092-uftc8inx 4128 48 . . . cord-010092-uftc8inx 4129 1 During during IN cord-010092-uftc8inx 4129 2 2018 2018 CD cord-010092-uftc8inx 4129 3 , , , cord-010092-uftc8inx 4129 4 TACT TACT NNP cord-010092-uftc8inx 4129 5 was be VBD cord-010092-uftc8inx 4129 6 offered offer VBN cord-010092-uftc8inx 4129 7 internationally internationally RB cord-010092-uftc8inx 4129 8 to to IN cord-010092-uftc8inx 4129 9 transfusion transfusion NN cord-010092-uftc8inx 4129 10 laboratory laboratory NN cord-010092-uftc8inx 4129 11 managers manager NNS cord-010092-uftc8inx 4129 12 to to IN cord-010092-uftc8inx 4129 13 trial trial NN cord-010092-uftc8inx 4129 14 , , , cord-010092-uftc8inx 4129 15 and and CC cord-010092-uftc8inx 4129 16 saw see VBD cord-010092-uftc8inx 4129 17 uptake uptake NN cord-010092-uftc8inx 4129 18 in in IN cord-010092-uftc8inx 4129 19 five five CD cord-010092-uftc8inx 4129 20 countries country NNS cord-010092-uftc8inx 4129 21 . . . cord-010092-uftc8inx 4130 1 The the DT cord-010092-uftc8inx 4130 2 core core NN cord-010092-uftc8inx 4130 3 TACT tact NN cord-010092-uftc8inx 4130 4 programme programme NN cord-010092-uftc8inx 4130 5 , , , cord-010092-uftc8inx 4130 6 based base VBN cord-010092-uftc8inx 4130 7 upon upon IN cord-010092-uftc8inx 4130 8 UK UK NNP cord-010092-uftc8inx 4130 9 guidelines guideline NNS cord-010092-uftc8inx 4130 10 , , , cord-010092-uftc8inx 4130 11 is be VBZ cord-010092-uftc8inx 4130 12 under under IN cord-010092-uftc8inx 4130 13 review review NN cord-010092-uftc8inx 4130 14 for for IN cord-010092-uftc8inx 4130 15 programming programming NN cord-010092-uftc8inx 4130 16 conversion conversion NN cord-010092-uftc8inx 4130 17 , , , cord-010092-uftc8inx 4130 18 to to TO cord-010092-uftc8inx 4130 19 be be VB cord-010092-uftc8inx 4130 20 customisable customisable JJ cord-010092-uftc8inx 4130 21 for for IN cord-010092-uftc8inx 4130 22 the the DT cord-010092-uftc8inx 4130 23 international international JJ cord-010092-uftc8inx 4130 24 community community NN cord-010092-uftc8inx 4130 25 . . . cord-010092-uftc8inx 4131 1 Aims aim VBZ cord-010092-uftc8inx 4131 2 : : : cord-010092-uftc8inx 4132 1 To to TO cord-010092-uftc8inx 4132 2 assess assess VB cord-010092-uftc8inx 4132 3 the the DT cord-010092-uftc8inx 4132 4 feasibility feasibility NN cord-010092-uftc8inx 4132 5 of of IN cord-010092-uftc8inx 4132 6 TACT tact NN cord-010092-uftc8inx 4132 7 programming programming NN cord-010092-uftc8inx 4132 8 conversion conversion NN cord-010092-uftc8inx 4132 9 to to TO cord-010092-uftc8inx 4132 10 meet meet VB cord-010092-uftc8inx 4132 11 the the DT cord-010092-uftc8inx 4132 12 requirements requirement NNS cord-010092-uftc8inx 4132 13 of of IN cord-010092-uftc8inx 4132 14 country country NN cord-010092-uftc8inx 4132 15 - - HYPH cord-010092-uftc8inx 4132 16 specific specific JJ cord-010092-uftc8inx 4132 17 pre pre JJ cord-010092-uftc8inx 4132 18 - - JJ cord-010092-uftc8inx 4132 19 transfusion transfusion JJ cord-010092-uftc8inx 4132 20 testing testing NN cord-010092-uftc8inx 4132 21 guidelines guideline NNS cord-010092-uftc8inx 4132 22 , , , cord-010092-uftc8inx 4132 23 and and CC cord-010092-uftc8inx 4132 24 to to TO cord-010092-uftc8inx 4132 25 direct direct VB cord-010092-uftc8inx 4132 26 future future JJ cord-010092-uftc8inx 4132 27 programming programming NN cord-010092-uftc8inx 4132 28 in in IN cord-010092-uftc8inx 4132 29 line line NN cord-010092-uftc8inx 4132 30 with with IN cord-010092-uftc8inx 4132 31 feedback feedback NN cord-010092-uftc8inx 4132 32 from from IN cord-010092-uftc8inx 4132 33 international international JJ cord-010092-uftc8inx 4132 34 users user NNS cord-010092-uftc8inx 4132 35 . . . cord-010092-uftc8inx 4133 1 Methods method NNS cord-010092-uftc8inx 4133 2 : : : cord-010092-uftc8inx 4134 1 Guidelines guideline NNS cord-010092-uftc8inx 4134 2 from from IN cord-010092-uftc8inx 4134 3 3/5 3/5 CD cord-010092-uftc8inx 4134 4 international international JJ cord-010092-uftc8inx 4134 5 users user NNS cord-010092-uftc8inx 4134 6 were be VBD cord-010092-uftc8inx 4134 7 obtained obtain VBN cord-010092-uftc8inx 4134 8 and and CC cord-010092-uftc8inx 4134 9 translated translate VBN cord-010092-uftc8inx 4134 10 where where WRB cord-010092-uftc8inx 4134 11 necessary necessary JJ cord-010092-uftc8inx 4134 12 . . . cord-010092-uftc8inx 4135 1 These these DT cord-010092-uftc8inx 4135 2 were be VBD cord-010092-uftc8inx 4135 3 compared compare VBN cord-010092-uftc8inx 4135 4 against against IN cord-010092-uftc8inx 4135 5 the the DT cord-010092-uftc8inx 4135 6 core core NN cord-010092-uftc8inx 4135 7 assessment assessment NN cord-010092-uftc8inx 4135 8 elements element NNS cord-010092-uftc8inx 4135 9 of of IN cord-010092-uftc8inx 4135 10 current current JJ cord-010092-uftc8inx 4135 11 TACT tact NN cord-010092-uftc8inx 4135 12 programming programming NN cord-010092-uftc8inx 4135 13 . . . cord-010092-uftc8inx 4136 1 International international JJ cord-010092-uftc8inx 4136 2 users user NNS cord-010092-uftc8inx 4136 3 were be VBD cord-010092-uftc8inx 4136 4 approached approach VBN cord-010092-uftc8inx 4136 5 for for IN cord-010092-uftc8inx 4136 6 their -PRON- PRP$ cord-010092-uftc8inx 4136 7 feedback feedback NN cord-010092-uftc8inx 4136 8 on on IN cord-010092-uftc8inx 4136 9 the the DT cord-010092-uftc8inx 4136 10 current current JJ cord-010092-uftc8inx 4136 11 version version NN cord-010092-uftc8inx 4136 12 of of IN cord-010092-uftc8inx 4136 13 TACT TACT NNP cord-010092-uftc8inx 4136 14 , , , cord-010092-uftc8inx 4136 15 as as IN cord-010092-uftc8inx 4136 16 it -PRON- PRP cord-010092-uftc8inx 4136 17 compared compare VBD cord-010092-uftc8inx 4136 18 to to IN cord-010092-uftc8inx 4136 19 their -PRON- PRP$ cord-010092-uftc8inx 4136 20 local local JJ cord-010092-uftc8inx 4136 21 policies policy NNS cord-010092-uftc8inx 4136 22 and and CC cord-010092-uftc8inx 4136 23 practices practice NNS cord-010092-uftc8inx 4136 24 . . . cord-010092-uftc8inx 4137 1 Results result NNS cord-010092-uftc8inx 4137 2 : : : cord-010092-uftc8inx 4138 1 The the DT cord-010092-uftc8inx 4138 2 following follow VBG cord-010092-uftc8inx 4138 3 criteria criterion NNS cord-010092-uftc8inx 4138 4 were be VBD cord-010092-uftc8inx 4138 5 cross cross JJ cord-010092-uftc8inx 4138 6 - - JJ cord-010092-uftc8inx 4138 7 referenced reference VBN cord-010092-uftc8inx 4138 8 : : : cord-010092-uftc8inx 4138 9 specification specification NN cord-010092-uftc8inx 4138 10 of of IN cord-010092-uftc8inx 4138 11 transfusion transfusion NN cord-010092-uftc8inx 4138 12 request request NN cord-010092-uftc8inx 4138 13 forms form NNS cord-010092-uftc8inx 4138 14 , , , cord-010092-uftc8inx 4138 15 sample sample NN cord-010092-uftc8inx 4138 16 label label NN cord-010092-uftc8inx 4138 17 acceptance acceptance NN cord-010092-uftc8inx 4138 18 criteria criterion NNS cord-010092-uftc8inx 4138 19 , , , cord-010092-uftc8inx 4138 20 reagents reagent NNS cord-010092-uftc8inx 4138 21 used use VBN cord-010092-uftc8inx 4138 22 for for IN cord-010092-uftc8inx 4138 23 ABO ABO NNP cord-010092-uftc8inx 4138 24 / / SYM cord-010092-uftc8inx 4138 25 D D NNP cord-010092-uftc8inx 4138 26 and and CC cord-010092-uftc8inx 4138 27 AS AS NNP cord-010092-uftc8inx 4138 28 / / SYM cord-010092-uftc8inx 4138 29 ID ID NNP cord-010092-uftc8inx 4138 30 , , , cord-010092-uftc8inx 4138 31 resolution resolution NN cord-010092-uftc8inx 4138 32 of of IN cord-010092-uftc8inx 4138 33 grouping grouping NN cord-010092-uftc8inx 4138 34 anomalies anomaly NNS cord-010092-uftc8inx 4138 35 , , , cord-010092-uftc8inx 4138 36 alloantibody alloantibody NN cord-010092-uftc8inx 4138 37 confirmation confirmation NN cord-010092-uftc8inx 4138 38 / / SYM cord-010092-uftc8inx 4138 39 exclusion exclusion NN cord-010092-uftc8inx 4138 40 , , , cord-010092-uftc8inx 4138 41 and and CC cord-010092-uftc8inx 4138 42 selection selection NN cord-010092-uftc8inx 4138 43 criteria criterion NNS cord-010092-uftc8inx 4138 44 of of IN cord-010092-uftc8inx 4138 45 blood blood NN cord-010092-uftc8inx 4138 46 components component NNS cord-010092-uftc8inx 4138 47 for for IN cord-010092-uftc8inx 4138 48 transfusion transfusion NN cord-010092-uftc8inx 4138 49 - - HYPH cord-010092-uftc8inx 4138 50 dependent dependent JJ cord-010092-uftc8inx 4138 51 patients patient NNS cord-010092-uftc8inx 4138 52 and and CC cord-010092-uftc8inx 4138 53 women woman NNS cord-010092-uftc8inx 4138 54 of of IN cord-010092-uftc8inx 4138 55 child child NN cord-010092-uftc8inx 4138 56 - - HYPH cord-010092-uftc8inx 4138 57 bearing bear VBG cord-010092-uftc8inx 4138 58 potential potential NN cord-010092-uftc8inx 4138 59 . . . cord-010092-uftc8inx 4139 1 Apparent apparent JJ cord-010092-uftc8inx 4139 2 differences difference NNS cord-010092-uftc8inx 4139 3 included:-Australia:--Selection included:-australia:--selection NN cord-010092-uftc8inx 4139 4 of of IN cord-010092-uftc8inx 4139 5 red red JJ cord-010092-uftc8inx 4139 6 cells cell NNS cord-010092-uftc8inx 4139 7 for for IN cord-010092-uftc8inx 4139 8 patients patient NNS cord-010092-uftc8inx 4139 9 with with IN cord-010092-uftc8inx 4139 10 immune immune JJ cord-010092-uftc8inx 4139 11 anti anti JJ cord-010092-uftc8inx 4139 12 - - JJ cord-010092-uftc8inx 4139 13 D. d. JJ cord-010092-uftc8inx 4139 14 Greece:--Inclusion greece:--inclusion NN cord-010092-uftc8inx 4139 15 of of IN cord-010092-uftc8inx 4139 16 the the DT cord-010092-uftc8inx 4139 17 name name NN cord-010092-uftc8inx 4139 18 of of IN cord-010092-uftc8inx 4139 19 the the DT cord-010092-uftc8inx 4139 20 patient patient NN cord-010092-uftc8inx 4139 21 's 's POS cord-010092-uftc8inx 4139 22 father father NN cord-010092-uftc8inx 4139 23 on on IN cord-010092-uftc8inx 4139 24 the the DT cord-010092-uftc8inx 4139 25 transfusion transfusion NN cord-010092-uftc8inx 4139 26 request request NN cord-010092-uftc8inx 4139 27 . . . cord-010092-uftc8inx 4140 1 Italy:--Testing italy:--teste VBG cord-010092-uftc8inx 4140 2 of of IN cord-010092-uftc8inx 4140 3 all all DT cord-010092-uftc8inx 4140 4 new new JJ cord-010092-uftc8inx 4140 5 patients patient NNS cord-010092-uftc8inx 4140 6 with with IN cord-010092-uftc8inx 4140 7 an an DT cord-010092-uftc8inx 4140 8 anti anti JJ cord-010092-uftc8inx 4140 9 - - JJ cord-010092-uftc8inx 4140 10 A a NN cord-010092-uftc8inx 4140 11 , , , cord-010092-uftc8inx 4140 12 B b NN cord-010092-uftc8inx 4140 13 reagent reagent NN cord-010092-uftc8inx 4140 14 and and CC cord-010092-uftc8inx 4140 15 two two CD cord-010092-uftc8inx 4140 16 different different JJ cord-010092-uftc8inx 4140 17 monoclonal monoclonal JJ cord-010092-uftc8inx 4140 18 anti anti JJ cord-010092-uftc8inx 4140 19 - - JJ cord-010092-uftc8inx 4140 20 D d JJ cord-010092-uftc8inx 4140 21 reagents reagent NNS cord-010092-uftc8inx 4140 22 . . . cord-010092-uftc8inx 4141 1 International international JJ cord-010092-uftc8inx 4141 2 users user NNS cord-010092-uftc8inx 4141 3 in in IN cord-010092-uftc8inx 4141 4 the the DT cord-010092-uftc8inx 4141 5 same same JJ cord-010092-uftc8inx 4141 6 three three CD cord-010092-uftc8inx 4141 7 countries country NNS cord-010092-uftc8inx 4141 8 supplied supply VBD cord-010092-uftc8inx 4141 9 feedback feedback NN cord-010092-uftc8inx 4141 10 . . . cord-010092-uftc8inx 4142 1 This this DT cord-010092-uftc8inx 4142 2 included include VBD cord-010092-uftc8inx 4142 3 suggestions suggestion NNS cord-010092-uftc8inx 4142 4 for:-greater for:-greater IN cord-010092-uftc8inx 4142 5 complexity complexity NN cord-010092-uftc8inx 4142 6 of of IN cord-010092-uftc8inx 4142 7 cases case NNS cord-010092-uftc8inx 4142 8 presented present VBN cord-010092-uftc8inx 4142 9 , , , cord-010092-uftc8inx 4142 10 provision provision NN cord-010092-uftc8inx 4142 11 of of IN cord-010092-uftc8inx 4142 12 patient patient JJ cord-010092-uftc8inx 4142 13 history history NN cord-010092-uftc8inx 4142 14 , , , cord-010092-uftc8inx 4142 15 inclusion inclusion NN cord-010092-uftc8inx 4142 16 of of IN cord-010092-uftc8inx 4142 17 follow follow NN cord-010092-uftc8inx 4142 18 - - HYPH cord-010092-uftc8inx 4142 19 on on RP cord-010092-uftc8inx 4142 20 tests test NNS cord-010092-uftc8inx 4142 21 e.g. e.g. IN cord-010092-uftc8inx 4142 22 phenotyping phenotyping NN cord-010092-uftc8inx 4142 23 and and CC cord-010092-uftc8inx 4142 24 cells cell NNS cord-010092-uftc8inx 4142 25 for for IN cord-010092-uftc8inx 4142 26 antibody antibody NN cord-010092-uftc8inx 4142 27 confirmation confirmation NN cord-010092-uftc8inx 4142 28 / / SYM cord-010092-uftc8inx 4142 29 exclusion exclusion NN cord-010092-uftc8inx 4142 30 , , , cord-010092-uftc8inx 4142 31 broader broad JJR cord-010092-uftc8inx 4142 32 range range NN cord-010092-uftc8inx 4142 33 of of IN cord-010092-uftc8inx 4142 34 reaction reaction NN cord-010092-uftc8inx 4142 35 strength strength NN cord-010092-uftc8inx 4142 36 grading grading NN cord-010092-uftc8inx 4142 37 , , , cord-010092-uftc8inx 4142 38 and and CC cord-010092-uftc8inx 4142 39 official official JJ cord-010092-uftc8inx 4142 40 professional professional JJ cord-010092-uftc8inx 4142 41 CPD CPD NNP cord-010092-uftc8inx 4142 42 credits credit NNS cord-010092-uftc8inx 4142 43 . . . cord-010092-uftc8inx 4143 1 The the DT cord-010092-uftc8inx 4143 2 following follow VBG cord-010092-uftc8inx 4143 3 differences difference NNS cord-010092-uftc8inx 4143 4 were be VBD cord-010092-uftc8inx 4143 5 noted:-nomenclature noted:-nomenclature NN cord-010092-uftc8inx 4143 6 used use VBN cord-010092-uftc8inx 4143 7 , , , cord-010092-uftc8inx 4143 8 the the DT cord-010092-uftc8inx 4143 9 format format NN cord-010092-uftc8inx 4143 10 and and CC cord-010092-uftc8inx 4143 11 content content NN cord-010092-uftc8inx 4143 12 of of IN cord-010092-uftc8inx 4143 13 the the DT cord-010092-uftc8inx 4143 14 request request NN cord-010092-uftc8inx 4143 15 form form NN cord-010092-uftc8inx 4143 16 , , , cord-010092-uftc8inx 4143 17 use use NN cord-010092-uftc8inx 4143 18 of of IN cord-010092-uftc8inx 4143 19 English english JJ cord-010092-uftc8inx 4143 20 abbreviations abbreviation NNS cord-010092-uftc8inx 4143 21 of of IN cord-010092-uftc8inx 4143 22 patient patient JJ cord-010092-uftc8inx 4143 23 clinical clinical JJ cord-010092-uftc8inx 4143 24 details detail NNS cord-010092-uftc8inx 4143 25 , , , cord-010092-uftc8inx 4143 26 and and CC cord-010092-uftc8inx 4143 27 the the DT cord-010092-uftc8inx 4143 28 availability availability NN cord-010092-uftc8inx 4143 29 , , , cord-010092-uftc8inx 4143 30 provision provision NN cord-010092-uftc8inx 4143 31 and and CC cord-010092-uftc8inx 4143 32 specification specification NN cord-010092-uftc8inx 4143 33 of of IN cord-010092-uftc8inx 4143 34 blood blood NN cord-010092-uftc8inx 4143 35 components component NNS cord-010092-uftc8inx 4143 36 . . . cord-010092-uftc8inx 4144 1 Summary Summary NNP cord-010092-uftc8inx 4144 2 / / SYM cord-010092-uftc8inx 4144 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 4144 4 : : : cord-010092-uftc8inx 4145 1 This this DT cord-010092-uftc8inx 4145 2 analysis analysis NN cord-010092-uftc8inx 4145 3 has have VBZ cord-010092-uftc8inx 4145 4 shown show VBN cord-010092-uftc8inx 4145 5 very very RB cord-010092-uftc8inx 4145 6 few few JJ cord-010092-uftc8inx 4145 7 instances instance NNS cord-010092-uftc8inx 4145 8 where where WRB cord-010092-uftc8inx 4145 9 the the DT cord-010092-uftc8inx 4145 10 current current JJ cord-010092-uftc8inx 4145 11 TACT tact NN cord-010092-uftc8inx 4145 12 iteration iteration NN cord-010092-uftc8inx 4145 13 differs differ VBZ cord-010092-uftc8inx 4145 14 from from IN cord-010092-uftc8inx 4145 15 the the DT cord-010092-uftc8inx 4145 16 guidelines guideline NNS cord-010092-uftc8inx 4145 17 reviewed review VBN cord-010092-uftc8inx 4145 18 , , , cord-010092-uftc8inx 4145 19 and and CC cord-010092-uftc8inx 4145 20 that that IN cord-010092-uftc8inx 4145 21 it -PRON- PRP cord-010092-uftc8inx 4145 22 is be VBZ cord-010092-uftc8inx 4145 23 feasible feasible JJ cord-010092-uftc8inx 4145 24 to to TO cord-010092-uftc8inx 4145 25 expand expand VB cord-010092-uftc8inx 4145 26 the the DT cord-010092-uftc8inx 4145 27 use use NN cord-010092-uftc8inx 4145 28 of of IN cord-010092-uftc8inx 4145 29 TACT tact NN cord-010092-uftc8inx 4145 30 on on IN cord-010092-uftc8inx 4145 31 a a DT cord-010092-uftc8inx 4145 32 more more RBR cord-010092-uftc8inx 4145 33 international international JJ cord-010092-uftc8inx 4145 34 basis basis NN cord-010092-uftc8inx 4145 35 . . . cord-010092-uftc8inx 4146 1 The the DT cord-010092-uftc8inx 4146 2 current current JJ cord-010092-uftc8inx 4146 3 iteration iteration NN cord-010092-uftc8inx 4146 4 of of IN cord-010092-uftc8inx 4146 5 TACT TACT NNP cord-010092-uftc8inx 4146 6 has have VBZ cord-010092-uftc8inx 4146 7 been be VBN cord-010092-uftc8inx 4146 8 developed develop VBN cord-010092-uftc8inx 4146 9 to to TO cord-010092-uftc8inx 4146 10 represent represent VB cord-010092-uftc8inx 4146 11 an an DT cord-010092-uftc8inx 4146 12 abbreviated abbreviated JJ cord-010092-uftc8inx 4146 13 scope scope NN cord-010092-uftc8inx 4146 14 of of IN cord-010092-uftc8inx 4146 15 pre pre JJ cord-010092-uftc8inx 4146 16 - - JJ cord-010092-uftc8inx 4146 17 transfusion transfusion JJ cord-010092-uftc8inx 4146 18 testing testing NN cord-010092-uftc8inx 4146 19 practices practice NNS cord-010092-uftc8inx 4146 20 , , , cord-010092-uftc8inx 4146 21 which which WDT cord-010092-uftc8inx 4146 22 can can MD cord-010092-uftc8inx 4146 23 be be VB cord-010092-uftc8inx 4146 24 applied apply VBN cord-010092-uftc8inx 4146 25 to to IN cord-010092-uftc8inx 4146 26 laboratory laboratory NN cord-010092-uftc8inx 4146 27 practice practice NN cord-010092-uftc8inx 4146 28 outside outside IN cord-010092-uftc8inx 4146 29 of of IN cord-010092-uftc8inx 4146 30 the the DT cord-010092-uftc8inx 4146 31 UK UK NNP cord-010092-uftc8inx 4146 32 without without IN cord-010092-uftc8inx 4146 33 difficulty difficulty NN cord-010092-uftc8inx 4146 34 . . . cord-010092-uftc8inx 4147 1 Further further JJ cord-010092-uftc8inx 4147 2 work work NN cord-010092-uftc8inx 4147 3 is be VBZ cord-010092-uftc8inx 4147 4 required require VBN cord-010092-uftc8inx 4147 5 to to TO cord-010092-uftc8inx 4147 6 enable enable VB cord-010092-uftc8inx 4147 7 international international JJ cord-010092-uftc8inx 4147 8 users user NNS cord-010092-uftc8inx 4147 9 to to TO cord-010092-uftc8inx 4147 10 configure configure VB cord-010092-uftc8inx 4147 11 TACT tact NN cord-010092-uftc8inx 4147 12 such such JJ cord-010092-uftc8inx 4147 13 that that IN cord-010092-uftc8inx 4147 14 the the DT cord-010092-uftc8inx 4147 15 system system NN cord-010092-uftc8inx 4147 16 represents represent VBZ cord-010092-uftc8inx 4147 17 all all DT cord-010092-uftc8inx 4147 18 laboratory laboratory NN cord-010092-uftc8inx 4147 19 practice practice NN cord-010092-uftc8inx 4147 20 on on IN cord-010092-uftc8inx 4147 21 an an DT cord-010092-uftc8inx 4147 22 international international JJ cord-010092-uftc8inx 4147 23 basis basis NN cord-010092-uftc8inx 4147 24 . . . cord-010092-uftc8inx 4148 1 Aims aim VBZ cord-010092-uftc8inx 4148 2 : : : cord-010092-uftc8inx 4149 1 These these DT cord-010092-uftc8inx 4149 2 courses course NNS cord-010092-uftc8inx 4149 3 provide provide VBP cord-010092-uftc8inx 4149 4 education education NN cord-010092-uftc8inx 4149 5 to to IN cord-010092-uftc8inx 4149 6 clinicians clinician NNS cord-010092-uftc8inx 4149 7 on on IN cord-010092-uftc8inx 4149 8 patient patient JJ cord-010092-uftc8inx 4149 9 blood blood NN cord-010092-uftc8inx 4149 10 management management NN cord-010092-uftc8inx 4149 11 and and CC cord-010092-uftc8inx 4149 12 safe safe JJ cord-010092-uftc8inx 4149 13 transfusion transfusion NN cord-010092-uftc8inx 4149 14 in in IN cord-010092-uftc8inx 4149 15 neonatal neonatal JJ cord-010092-uftc8inx 4149 16 and and CC cord-010092-uftc8inx 4149 17 paediatric paediatric JJ cord-010092-uftc8inx 4149 18 settings setting NNS cord-010092-uftc8inx 4149 19 in in IN cord-010092-uftc8inx 4149 20 order order NN cord-010092-uftc8inx 4149 21 to to TO cord-010092-uftc8inx 4149 22 improve improve VB cord-010092-uftc8inx 4149 23 patient patient JJ cord-010092-uftc8inx 4149 24 outcomes outcome NNS cord-010092-uftc8inx 4149 25 and and CC cord-010092-uftc8inx 4149 26 increase increase VB cord-010092-uftc8inx 4149 27 awareness awareness NN cord-010092-uftc8inx 4149 28 of of IN cord-010092-uftc8inx 4149 29 the the DT cord-010092-uftc8inx 4149 30 national national JJ cord-010092-uftc8inx 4149 31 patient patient NN cord-010092-uftc8inx 4149 32 blood blood NN cord-010092-uftc8inx 4149 33 management management NN cord-010092-uftc8inx 4149 34 guidelines guideline NNS cord-010092-uftc8inx 4149 35 . . . cord-010092-uftc8inx 4150 1 This this DT cord-010092-uftc8inx 4150 2 analysis analysis NN cord-010092-uftc8inx 4150 3 aimed aim VBN cord-010092-uftc8inx 4150 4 to to TO cord-010092-uftc8inx 4150 5 investigate investigate VB cord-010092-uftc8inx 4150 6 the the DT cord-010092-uftc8inx 4150 7 uptake uptake NN cord-010092-uftc8inx 4150 8 , , , cord-010092-uftc8inx 4150 9 practical practical JJ cord-010092-uftc8inx 4150 10 use use NN cord-010092-uftc8inx 4150 11 , , , cord-010092-uftc8inx 4150 12 and and CC cord-010092-uftc8inx 4150 13 perceived perceive VBN cord-010092-uftc8inx 4150 14 value value NN cord-010092-uftc8inx 4150 15 of of IN cord-010092-uftc8inx 4150 16 the the DT cord-010092-uftc8inx 4150 17 courses course NNS cord-010092-uftc8inx 4150 18 by by IN cord-010092-uftc8inx 4150 19 learners learner NNS cord-010092-uftc8inx 4150 20 . . . cord-010092-uftc8inx 4151 1 Methods method NNS cord-010092-uftc8inx 4151 2 : : : cord-010092-uftc8inx 4152 1 A a DT cord-010092-uftc8inx 4152 2 retrospective retrospective JJ cord-010092-uftc8inx 4152 3 analysis analysis NN cord-010092-uftc8inx 4152 4 of of IN cord-010092-uftc8inx 4152 5 course course NN cord-010092-uftc8inx 4152 6 completion completion NN cord-010092-uftc8inx 4152 7 statistics statistic NNS cord-010092-uftc8inx 4152 8 and and CC cord-010092-uftc8inx 4152 9 course course NN cord-010092-uftc8inx 4152 10 evaluation evaluation NN cord-010092-uftc8inx 4152 11 data datum NNS cord-010092-uftc8inx 4152 12 . . . cord-010092-uftc8inx 4153 1 Results result NNS cord-010092-uftc8inx 4153 2 : : : cord-010092-uftc8inx 4154 1 There there EX cord-010092-uftc8inx 4154 2 have have VBP cord-010092-uftc8inx 4154 3 been be VBN cord-010092-uftc8inx 4154 4 2,376 2,376 CD cord-010092-uftc8inx 4154 5 paediatric paediatric JJ cord-010092-uftc8inx 4154 6 and and CC cord-010092-uftc8inx 4154 7 neonatal neonatal JJ cord-010092-uftc8inx 4154 8 courses course NNS cord-010092-uftc8inx 4154 9 completed complete VBN cord-010092-uftc8inx 4154 10 from from IN cord-010092-uftc8inx 4154 11 6 6 CD cord-010092-uftc8inx 4154 12 March March NNP cord-010092-uftc8inx 4154 13 2018 2018 CD cord-010092-uftc8inx 4154 14 to to IN cord-010092-uftc8inx 4154 15 28 28 CD cord-010092-uftc8inx 4154 16 February February NNP cord-010092-uftc8inx 4154 17 2019 2019 CD cord-010092-uftc8inx 4154 18 with with IN cord-010092-uftc8inx 4154 19 89.6 89.6 CD cord-010092-uftc8inx 4154 20 % % NN cord-010092-uftc8inx 4154 21 of of IN cord-010092-uftc8inx 4154 22 learners learner NNS cord-010092-uftc8inx 4154 23 being be VBG cord-010092-uftc8inx 4154 24 nurses nurse NNS cord-010092-uftc8inx 4154 25 and/or and/or CC cord-010092-uftc8inx 4154 26 midwives midwife NNS cord-010092-uftc8inx 4154 27 . . . cord-010092-uftc8inx 4155 1 Analysis analysis NN cord-010092-uftc8inx 4155 2 of of IN cord-010092-uftc8inx 4155 3 course course NN cord-010092-uftc8inx 4155 4 evaluation evaluation NN cord-010092-uftc8inx 4155 5 data datum NNS cord-010092-uftc8inx 4155 6 ( ( -LRB- cord-010092-uftc8inx 4155 7 n n NN cord-010092-uftc8inx 4155 8 = = SYM cord-010092-uftc8inx 4155 9 33 33 CD cord-010092-uftc8inx 4155 10 ) ) -RRB- cord-010092-uftc8inx 4155 11 showed show VBD cord-010092-uftc8inx 4155 12 that that IN cord-010092-uftc8inx 4155 13 these these DT cord-010092-uftc8inx 4155 14 courses course NNS cord-010092-uftc8inx 4155 15 : : : cord-010092-uftc8inx 4156 1 -Provide -Provide : cord-010092-uftc8inx 4156 2 knowledge knowledge NN cord-010092-uftc8inx 4156 3 ( ( -LRB- cord-010092-uftc8inx 4156 4 96.9 96.9 CD cord-010092-uftc8inx 4156 5 % % NN cord-010092-uftc8inx 4156 6 ) ) -RRB- cord-010092-uftc8inx 4157 1 -Improve -improve IN cord-010092-uftc8inx 4157 2 patient patient JJ cord-010092-uftc8inx 4157 3 safety safety NN cord-010092-uftc8inx 4157 4 and and CC cord-010092-uftc8inx 4157 5 outcomes outcome NNS cord-010092-uftc8inx 4157 6 ( ( -LRB- cord-010092-uftc8inx 4157 7 84.9 84.9 CD cord-010092-uftc8inx 4157 8 % % NN cord-010092-uftc8inx 4157 9 ) ) -RRB- cord-010092-uftc8inx 4158 1 -Result -Result : cord-010092-uftc8inx 4158 2 in in IN cord-010092-uftc8inx 4158 3 change change NN cord-010092-uftc8inx 4158 4 to to IN cord-010092-uftc8inx 4158 5 clinical clinical JJ cord-010092-uftc8inx 4158 6 practice practice NN cord-010092-uftc8inx 4158 7 ( ( -LRB- cord-010092-uftc8inx 4158 8 69.9 69.9 CD cord-010092-uftc8inx 4158 9 % % NN cord-010092-uftc8inx 4158 10 ) ) -RRB- cord-010092-uftc8inx 4158 11 -Are -Are : cord-010092-uftc8inx 4158 12 relevant relevant JJ cord-010092-uftc8inx 4158 13 to to IN cord-010092-uftc8inx 4158 14 clinical clinical JJ cord-010092-uftc8inx 4158 15 practice practice NN cord-010092-uftc8inx 4158 16 ( ( -LRB- cord-010092-uftc8inx 4158 17 70.9 70.9 CD cord-010092-uftc8inx 4158 18 % % NN cord-010092-uftc8inx 4158 19 ) ) -RRB- cord-010092-uftc8inx 4158 20 -Are -Are : cord-010092-uftc8inx 4158 21 easy easy JJ cord-010092-uftc8inx 4158 22 to to TO cord-010092-uftc8inx 4158 23 use use VB cord-010092-uftc8inx 4158 24 ( ( -LRB- cord-010092-uftc8inx 4158 25 67.7 67.7 CD cord-010092-uftc8inx 4158 26 % % NN cord-010092-uftc8inx 4158 27 ) ) -RRB- cord-010092-uftc8inx 4159 1 -Are -Are : cord-010092-uftc8inx 4159 2 readily readily RB cord-010092-uftc8inx 4159 3 accessible accessible JJ cord-010092-uftc8inx 4159 4 ( ( -LRB- cord-010092-uftc8inx 4159 5 58.1 58.1 CD cord-010092-uftc8inx 4159 6 % % NN cord-010092-uftc8inx 4159 7 ) ) -RRB- cord-010092-uftc8inx 4159 8 . . . cord-010092-uftc8inx 4160 1 Examples example NNS cord-010092-uftc8inx 4160 2 that that WDT cord-010092-uftc8inx 4160 3 learners learner NNS cord-010092-uftc8inx 4160 4 provided provide VBN cord-010092-uftc8inx 4160 5 of of IN cord-010092-uftc8inx 4160 6 how how WRB cord-010092-uftc8inx 4160 7 they -PRON- PRP cord-010092-uftc8inx 4160 8 can can MD cord-010092-uftc8inx 4160 9 apply apply VB cord-010092-uftc8inx 4160 10 this this DT cord-010092-uftc8inx 4160 11 learning learning NN cord-010092-uftc8inx 4160 12 to to IN cord-010092-uftc8inx 4160 13 their -PRON- PRP$ cord-010092-uftc8inx 4160 14 clinical clinical JJ cord-010092-uftc8inx 4160 15 practice practice NN cord-010092-uftc8inx 4160 16 include include VBP cord-010092-uftc8inx 4160 17 : : : cord-010092-uftc8inx 4161 1 -"[I -"[I NNP cord-010092-uftc8inx 4161 2 am be VBP cord-010092-uftc8inx 4161 3 now now RB cord-010092-uftc8inx 4161 4 ] ] -RRB- cord-010092-uftc8inx 4161 5 more more RBR cord-010092-uftc8inx 4161 6 aware aware JJ cord-010092-uftc8inx 4161 7 of of IN cord-010092-uftc8inx 4161 8 special special JJ cord-010092-uftc8inx 4161 9 requirements requirement NNS cord-010092-uftc8inx 4161 10 for for IN cord-010092-uftc8inx 4161 11 neonatal neonatal JJ cord-010092-uftc8inx 4161 12 blood blood NN cord-010092-uftc8inx 4161 13 transfusion transfusion NN cord-010092-uftc8inx 4161 14 " " '' cord-010092-uftc8inx 4162 1 -"[I -"[I -LRB- cord-010092-uftc8inx 4162 2 ] ] -RRB- cord-010092-uftc8inx 4162 3 feel feel VB cord-010092-uftc8inx 4162 4 more more RBR cord-010092-uftc8inx 4162 5 confident confident JJ cord-010092-uftc8inx 4162 6 especially especially RB cord-010092-uftc8inx 4162 7 when when WRB cord-010092-uftc8inx 4162 8 talking talk VBG cord-010092-uftc8inx 4162 9 with with IN cord-010092-uftc8inx 4162 10 parents parent NNS cord-010092-uftc8inx 4162 11 " " `` cord-010092-uftc8inx 4162 12 -"[I -"[I -LRB- cord-010092-uftc8inx 4162 13 will will MD cord-010092-uftc8inx 4162 14 now now RB cord-010092-uftc8inx 4162 15 be be VB cord-010092-uftc8inx 4162 16 ] ] -RRB- cord-010092-uftc8inx 4162 17 checking check VBG cord-010092-uftc8inx 4162 18 the the DT cord-010092-uftc8inx 4162 19 patient patient NN cord-010092-uftc8inx 4162 20 's 's POS cord-010092-uftc8inx 4162 21 blood blood NN cord-010092-uftc8inx 4162 22 results result NNS cord-010092-uftc8inx 4162 23 and and CC cord-010092-uftc8inx 4162 24 will will MD cord-010092-uftc8inx 4162 25 speak speak VB cord-010092-uftc8inx 4162 26 up up RP cord-010092-uftc8inx 4162 27 for for IN cord-010092-uftc8inx 4162 28 unnecessary unnecessary JJ cord-010092-uftc8inx 4162 29 blood blood NN cord-010092-uftc8inx 4162 30 sampling sampling NN cord-010092-uftc8inx 4162 31 " " '' cord-010092-uftc8inx 4162 32 -"[It -"[It : cord-010092-uftc8inx 4162 33 's 's POS cord-010092-uftc8inx 4162 34 good good JJ cord-010092-uftc8inx 4162 35 that that DT cord-010092-uftc8inx 4162 36 ] ] -RRB- cord-010092-uftc8inx 4162 37 when when WRB cord-010092-uftc8inx 4162 38 there there EX cord-010092-uftc8inx 4162 39 is be VBZ cord-010092-uftc8inx 4162 40 ambiguity ambiguity NN cord-010092-uftc8inx 4162 41 in in IN cord-010092-uftc8inx 4162 42 clinical clinical JJ cord-010092-uftc8inx 4162 43 practice practice NN cord-010092-uftc8inx 4162 44 [ [ -LRB- cord-010092-uftc8inx 4162 45 this this DT cord-010092-uftc8inx 4162 46 is be VBZ cord-010092-uftc8inx 4162 47 ] ] -RRB- cord-010092-uftc8inx 4162 48 very very RB cord-010092-uftc8inx 4162 49 well well RB cord-010092-uftc8inx 4162 50 shown show VBN cord-010092-uftc8inx 4162 51 by by IN cord-010092-uftc8inx 4162 52 explanation explanation NN cord-010092-uftc8inx 4162 53 from from IN cord-010092-uftc8inx 4162 54 experts expert NNS cord-010092-uftc8inx 4162 55 in in IN cord-010092-uftc8inx 4162 56 the the DT cord-010092-uftc8inx 4162 57 field field NN cord-010092-uftc8inx 4162 58 " " '' cord-010092-uftc8inx 4162 59 -"We -"We . cord-010092-uftc8inx 4162 60 do do VBP cord-010092-uftc8inx 4162 61 n't not RB cord-010092-uftc8inx 4162 62 do do VB cord-010092-uftc8inx 4162 63 a a DT cord-010092-uftc8inx 4162 64 lot lot NN cord-010092-uftc8inx 4162 65 of of IN cord-010092-uftc8inx 4162 66 transfusions transfusion NNS cord-010092-uftc8inx 4162 67 [ [ -LRB- cord-010092-uftc8inx 4162 68 and and CC cord-010092-uftc8inx 4162 69 this this DT cord-010092-uftc8inx 4162 70 is be VBZ cord-010092-uftc8inx 4162 71 ] ] -RRB- cord-010092-uftc8inx 4162 72 a a DT cord-010092-uftc8inx 4162 73 reminder reminder NN cord-010092-uftc8inx 4162 74 that that IN cord-010092-uftc8inx 4162 75 transfusions transfusion NNS cord-010092-uftc8inx 4162 76 are be VBP cord-010092-uftc8inx 4162 77 not not RB cord-010092-uftc8inx 4162 78 always always RB cord-010092-uftc8inx 4162 79 the the DT cord-010092-uftc8inx 4162 80 first first JJ cord-010092-uftc8inx 4162 81 answer answer NN cord-010092-uftc8inx 4162 82 to to IN cord-010092-uftc8inx 4162 83 the the DT cord-010092-uftc8inx 4162 84 baby baby NN cord-010092-uftc8inx 4162 85 's 's POS cord-010092-uftc8inx 4162 86 clinical clinical JJ cord-010092-uftc8inx 4162 87 picture picture NN cord-010092-uftc8inx 4162 88 " " '' cord-010092-uftc8inx 4162 89 . . . cord-010092-uftc8inx 4163 1 Summary Summary NNP cord-010092-uftc8inx 4163 2 / / SYM cord-010092-uftc8inx 4163 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 4163 4 : : : cord-010092-uftc8inx 4164 1 Analysis analysis NN cord-010092-uftc8inx 4164 2 of of IN cord-010092-uftc8inx 4164 3 course course NN cord-010092-uftc8inx 4164 4 and and CC cord-010092-uftc8inx 4164 5 user user NN cord-010092-uftc8inx 4164 6 evaluation evaluation NN cord-010092-uftc8inx 4164 7 data datum NNS cord-010092-uftc8inx 4164 8 demonstrates demonstrate VBZ cord-010092-uftc8inx 4164 9 that that IN cord-010092-uftc8inx 4164 10 these these DT cord-010092-uftc8inx 4164 11 courses course NNS cord-010092-uftc8inx 4164 12 are be VBP cord-010092-uftc8inx 4164 13 being be VBG cord-010092-uftc8inx 4164 14 used use VBN cord-010092-uftc8inx 4164 15 by by IN cord-010092-uftc8inx 4164 16 nurses nurse NNS cord-010092-uftc8inx 4164 17 and and CC cord-010092-uftc8inx 4164 18 doctors doctor NNS cord-010092-uftc8inx 4164 19 working work VBG cord-010092-uftc8inx 4164 20 in in IN cord-010092-uftc8inx 4164 21 the the DT cord-010092-uftc8inx 4164 22 neonatal neonatal JJ cord-010092-uftc8inx 4164 23 and and CC cord-010092-uftc8inx 4164 24 paediatric paediatric JJ cord-010092-uftc8inx 4164 25 settings setting NNS cord-010092-uftc8inx 4164 26 and and CC cord-010092-uftc8inx 4164 27 that that IN cord-010092-uftc8inx 4164 28 they -PRON- PRP cord-010092-uftc8inx 4164 29 provide provide VBP cord-010092-uftc8inx 4164 30 knowledge knowledge NN cord-010092-uftc8inx 4164 31 of of IN cord-010092-uftc8inx 4164 32 PBM PBM NNP cord-010092-uftc8inx 4164 33 that that WDT cord-010092-uftc8inx 4164 34 can can MD cord-010092-uftc8inx 4164 35 be be VB cord-010092-uftc8inx 4164 36 applied apply VBN cord-010092-uftc8inx 4164 37 to to IN cord-010092-uftc8inx 4164 38 clinical clinical JJ cord-010092-uftc8inx 4164 39 practice practice NN cord-010092-uftc8inx 4164 40 , , , cord-010092-uftc8inx 4164 41 thereby thereby RB cord-010092-uftc8inx 4164 42 contributing contribute VBG cord-010092-uftc8inx 4164 43 to to IN cord-010092-uftc8inx 4164 44 improved improved JJ cord-010092-uftc8inx 4164 45 patient patient JJ cord-010092-uftc8inx 4164 46 care care NN cord-010092-uftc8inx 4164 47 . . . cord-010092-uftc8inx 4165 1 Background background NN cord-010092-uftc8inx 4165 2 : : : cord-010092-uftc8inx 4166 1 Blood blood NN cord-010092-uftc8inx 4166 2 transfusion transfusion NN cord-010092-uftc8inx 4166 3 is be VBZ cord-010092-uftc8inx 4166 4 a a DT cord-010092-uftc8inx 4166 5 high high JJ cord-010092-uftc8inx 4166 6 - - HYPH cord-010092-uftc8inx 4166 7 risk risk NN cord-010092-uftc8inx 4166 8 clinical clinical JJ cord-010092-uftc8inx 4166 9 activity activity NN cord-010092-uftc8inx 4166 10 that that WDT cord-010092-uftc8inx 4166 11 must must MD cord-010092-uftc8inx 4166 12 be be VB cord-010092-uftc8inx 4166 13 mastered master VBN cord-010092-uftc8inx 4166 14 both both CC cord-010092-uftc8inx 4166 15 theoretically theoretically RB cord-010092-uftc8inx 4166 16 and and CC cord-010092-uftc8inx 4166 17 practically practically RB cord-010092-uftc8inx 4166 18 in in IN cord-010092-uftc8inx 4166 19 order order NN cord-010092-uftc8inx 4166 20 to to TO cord-010092-uftc8inx 4166 21 guarantee guarantee VB cord-010092-uftc8inx 4166 22 the the DT cord-010092-uftc8inx 4166 23 required require VBN cord-010092-uftc8inx 4166 24 result result NN cord-010092-uftc8inx 4166 25 without without IN cord-010092-uftc8inx 4166 26 any any DT cord-010092-uftc8inx 4166 27 incident incident NN cord-010092-uftc8inx 4166 28 or or CC cord-010092-uftc8inx 4166 29 complications complication NNS cord-010092-uftc8inx 4166 30 . . . cord-010092-uftc8inx 4167 1 The the DT cord-010092-uftc8inx 4167 2 mastery mastery NN cord-010092-uftc8inx 4167 3 of of IN cord-010092-uftc8inx 4167 4 transfusion transfusion NN cord-010092-uftc8inx 4167 5 knowledge knowledge NN cord-010092-uftc8inx 4167 6 among among IN cord-010092-uftc8inx 4167 7 nurses nurse NNS cord-010092-uftc8inx 4167 8 represents represent VBZ cord-010092-uftc8inx 4167 9 a a DT cord-010092-uftc8inx 4167 10 very very RB cord-010092-uftc8inx 4167 11 important important JJ cord-010092-uftc8inx 4167 12 link link NN cord-010092-uftc8inx 4167 13 in in IN cord-010092-uftc8inx 4167 14 the the DT cord-010092-uftc8inx 4167 15 transfusion transfusion NN cord-010092-uftc8inx 4167 16 chain chain NN cord-010092-uftc8inx 4167 17 . . . cord-010092-uftc8inx 4168 1 The the DT cord-010092-uftc8inx 4168 2 objective objective NN cord-010092-uftc8inx 4168 3 of of IN cord-010092-uftc8inx 4168 4 this this DT cord-010092-uftc8inx 4168 5 work work NN cord-010092-uftc8inx 4168 6 is be VBZ cord-010092-uftc8inx 4168 7 to to TO cord-010092-uftc8inx 4168 8 compare compare VB cord-010092-uftc8inx 4168 9 the the DT cord-010092-uftc8inx 4168 10 theoretical theoretical JJ cord-010092-uftc8inx 4168 11 and and CC cord-010092-uftc8inx 4168 12 practical practical JJ cord-010092-uftc8inx 4168 13 knowledge knowledge NN cord-010092-uftc8inx 4168 14 of of IN cord-010092-uftc8inx 4168 15 transfusion transfusion NN cord-010092-uftc8inx 4168 16 among among IN cord-010092-uftc8inx 4168 17 two two CD cord-010092-uftc8inx 4168 18 groups group NNS cord-010092-uftc8inx 4168 19 of of IN cord-010092-uftc8inx 4168 20 nurses nurse NNS cord-010092-uftc8inx 4168 21 divided divide VBN cord-010092-uftc8inx 4168 22 according accord VBG cord-010092-uftc8inx 4168 23 to to IN cord-010092-uftc8inx 4168 24 their -PRON- PRP$ cord-010092-uftc8inx 4168 25 seniority seniority NN cord-010092-uftc8inx 4168 26 . . . cord-010092-uftc8inx 4169 1 Aims aim VBZ cord-010092-uftc8inx 4169 2 : : : cord-010092-uftc8inx 4169 3 This this DT cord-010092-uftc8inx 4169 4 is be VBZ cord-010092-uftc8inx 4169 5 a a DT cord-010092-uftc8inx 4169 6 cross cross JJ cord-010092-uftc8inx 4169 7 - - JJ cord-010092-uftc8inx 4169 8 sectional sectional JJ cord-010092-uftc8inx 4169 9 descriptive descriptive JJ cord-010092-uftc8inx 4169 10 study study NN cord-010092-uftc8inx 4169 11 conducted conduct VBN cord-010092-uftc8inx 4169 12 over over IN cord-010092-uftc8inx 4169 13 a a DT cord-010092-uftc8inx 4169 14 period period NN cord-010092-uftc8inx 4169 15 of of IN cord-010092-uftc8inx 4169 16 1 1 CD cord-010092-uftc8inx 4169 17 month month NN cord-010092-uftc8inx 4170 1 [ [ -LRB- cord-010092-uftc8inx 4170 2 1 1 CD cord-010092-uftc8inx 4170 3 st st NNP cord-010092-uftc8inx 4170 4 April-30 April-30 NNP cord-010092-uftc8inx 4170 5 th th DT cord-010092-uftc8inx 4170 6 April April NNP cord-010092-uftc8inx 4170 7 ] ] -RRB- cord-010092-uftc8inx 4170 8 2017 2017 CD cord-010092-uftc8inx 4170 9 . . . cord-010092-uftc8inx 4171 1 We -PRON- PRP cord-010092-uftc8inx 4171 2 selected select VBD cord-010092-uftc8inx 4171 3 two two CD cord-010092-uftc8inx 4171 4 groups group NNS cord-010092-uftc8inx 4171 5 of of IN cord-010092-uftc8inx 4171 6 care care NN cord-010092-uftc8inx 4171 7 staff staff NN cord-010092-uftc8inx 4171 8 : : : cord-010092-uftc8inx 4172 1 the the DT cord-010092-uftc8inx 4172 2 1 1 CD cord-010092-uftc8inx 4172 3 st st NNP cord-010092-uftc8inx 4172 4 group group NNP cord-010092-uftc8inx 4172 5 consists consist VBZ cord-010092-uftc8inx 4172 6 of of IN cord-010092-uftc8inx 4172 7 50 50 CD cord-010092-uftc8inx 4172 8 students student NNS cord-010092-uftc8inx 4172 9 at at IN cord-010092-uftc8inx 4172 10 the the DT cord-010092-uftc8inx 4172 11 end end NN cord-010092-uftc8inx 4172 12 of of IN cord-010092-uftc8inx 4172 13 their -PRON- PRP$ cord-010092-uftc8inx 4172 14 training training NN cord-010092-uftc8inx 4172 15 at at IN cord-010092-uftc8inx 4172 16 the the DT cord-010092-uftc8inx 4172 17 higher high JJR cord-010092-uftc8inx 4172 18 Institute Institute NNP cord-010092-uftc8inx 4172 19 of of IN cord-010092-uftc8inx 4172 20 Nursing Nursing NNP cord-010092-uftc8inx 4172 21 Sciences Sciences NNPS cord-010092-uftc8inx 4172 22 . . . cord-010092-uftc8inx 4173 1 The the DT cord-010092-uftc8inx 4173 2 2 2 CD cord-010092-uftc8inx 4173 3 nd nd NNP cord-010092-uftc8inx 4173 4 is be VBZ cord-010092-uftc8inx 4173 5 made make VBN cord-010092-uftc8inx 4173 6 up up RP cord-010092-uftc8inx 4173 7 of of IN cord-010092-uftc8inx 4173 8 50 50 CD cord-010092-uftc8inx 4173 9 nurses nurse NNS cord-010092-uftc8inx 4173 10 working work VBG cord-010092-uftc8inx 4173 11 in in IN cord-010092-uftc8inx 4173 12 5 5 CD cord-010092-uftc8inx 4173 13 university university NN cord-010092-uftc8inx 4173 14 hospitals hospital NNS cord-010092-uftc8inx 4173 15 of of IN cord-010092-uftc8inx 4173 16 Tunis Tunis NNP cord-010092-uftc8inx 4173 17 , , , cord-010092-uftc8inx 4173 18 currently currently RB cord-010092-uftc8inx 4173 19 practicing practice VBG cord-010092-uftc8inx 4173 20 blood blood NN cord-010092-uftc8inx 4173 21 transfusion transfusion NN cord-010092-uftc8inx 4173 22 . . . cord-010092-uftc8inx 4174 1 The the DT cord-010092-uftc8inx 4174 2 evaluation evaluation NN cord-010092-uftc8inx 4174 3 's 's POS cord-010092-uftc8inx 4174 4 tool tool NN cord-010092-uftc8inx 4174 5 used use VBN cord-010092-uftc8inx 4174 6 was be VBD cord-010092-uftc8inx 4174 7 a a DT cord-010092-uftc8inx 4174 8 questionnaire questionnaire NN cord-010092-uftc8inx 4174 9 of of IN cord-010092-uftc8inx 4174 10 15 15 CD cord-010092-uftc8inx 4174 11 simple simple JJ cord-010092-uftc8inx 4174 12 or or CC cord-010092-uftc8inx 4174 13 multiple multiple JJ cord-010092-uftc8inx 4174 14 choice choice NN cord-010092-uftc8inx 4174 15 questions question NNS cord-010092-uftc8inx 4174 16 , , , cord-010092-uftc8inx 4174 17 7 7 CD cord-010092-uftc8inx 4174 18 were be VBD cord-010092-uftc8inx 4174 19 related relate VBN cord-010092-uftc8inx 4174 20 to to IN cord-010092-uftc8inx 4174 21 theoretical theoretical JJ cord-010092-uftc8inx 4174 22 knowledge knowledge NN cord-010092-uftc8inx 4174 23 of of IN cord-010092-uftc8inx 4174 24 labile labile JJ cord-010092-uftc8inx 4174 25 blood blood NN cord-010092-uftc8inx 4174 26 products product NNS cord-010092-uftc8inx 4174 27 and and CC cord-010092-uftc8inx 4174 28 8 8 CD cord-010092-uftc8inx 4174 29 to to IN cord-010092-uftc8inx 4174 30 transfusion transfusion NN cord-010092-uftc8inx 4174 31 practice practice NN cord-010092-uftc8inx 4174 32 . . . cord-010092-uftc8inx 4175 1 Ten ten CD cord-010092-uftc8inx 4175 2 questions question NNS cord-010092-uftc8inx 4175 3 were be VBD cord-010092-uftc8inx 4175 4 considered consider VBN cord-010092-uftc8inx 4175 5 " " `` cord-010092-uftc8inx 4175 6 life life NN cord-010092-uftc8inx 4175 7 - - HYPH cord-010092-uftc8inx 4175 8 threatening threaten VBG cord-010092-uftc8inx 4175 9 " " '' cord-010092-uftc8inx 4175 10 if if IN cord-010092-uftc8inx 4175 11 their -PRON- PRP$ cord-010092-uftc8inx 4175 12 answers answer NNS cord-010092-uftc8inx 4175 13 were be VBD cord-010092-uftc8inx 4175 14 false false JJ cord-010092-uftc8inx 4175 15 . . . cord-010092-uftc8inx 4176 1 A a DT cord-010092-uftc8inx 4176 2 comparative comparative JJ cord-010092-uftc8inx 4176 3 study study NN cord-010092-uftc8inx 4176 4 was be VBD cord-010092-uftc8inx 4176 5 made make VBN cord-010092-uftc8inx 4176 6 between between IN cord-010092-uftc8inx 4176 7 the the DT cord-010092-uftc8inx 4176 8 two two CD cord-010092-uftc8inx 4176 9 groups group NNS cord-010092-uftc8inx 4176 10 . . . cord-010092-uftc8inx 4177 1 Methods method NNS cord-010092-uftc8inx 4177 2 : : : cord-010092-uftc8inx 4177 3 This this DT cord-010092-uftc8inx 4177 4 is be VBZ cord-010092-uftc8inx 4177 5 a a DT cord-010092-uftc8inx 4177 6 cross cross JJ cord-010092-uftc8inx 4177 7 - - JJ cord-010092-uftc8inx 4177 8 sectional sectional JJ cord-010092-uftc8inx 4177 9 descriptive descriptive JJ cord-010092-uftc8inx 4177 10 study study NN cord-010092-uftc8inx 4177 11 conducted conduct VBN cord-010092-uftc8inx 4177 12 over over IN cord-010092-uftc8inx 4177 13 a a DT cord-010092-uftc8inx 4177 14 period period NN cord-010092-uftc8inx 4177 15 of of IN cord-010092-uftc8inx 4177 16 1 1 CD cord-010092-uftc8inx 4177 17 month month NN cord-010092-uftc8inx 4177 18 [ [ -LRB- cord-010092-uftc8inx 4177 19 1 1 CD cord-010092-uftc8inx 4177 20 st st NNP cord-010092-uftc8inx 4177 21 April-30 April-30 NNP cord-010092-uftc8inx 4177 22 th th DT cord-010092-uftc8inx 4177 23 April April NNP cord-010092-uftc8inx 4177 24 ] ] -RRB- cord-010092-uftc8inx 4177 25 2017 2017 CD cord-010092-uftc8inx 4177 26 . . . cord-010092-uftc8inx 4178 1 We -PRON- PRP cord-010092-uftc8inx 4178 2 selected select VBD cord-010092-uftc8inx 4178 3 two two CD cord-010092-uftc8inx 4178 4 groups group NNS cord-010092-uftc8inx 4178 5 of of IN cord-010092-uftc8inx 4178 6 care care NN cord-010092-uftc8inx 4178 7 staff staff NN cord-010092-uftc8inx 4178 8 : : : cord-010092-uftc8inx 4179 1 the the DT cord-010092-uftc8inx 4179 2 1 1 CD cord-010092-uftc8inx 4179 3 st st NNP cord-010092-uftc8inx 4179 4 group group NNP cord-010092-uftc8inx 4179 5 consists consist VBZ cord-010092-uftc8inx 4179 6 of of IN cord-010092-uftc8inx 4179 7 50 50 CD cord-010092-uftc8inx 4179 8 students student NNS cord-010092-uftc8inx 4179 9 at at IN cord-010092-uftc8inx 4179 10 the the DT cord-010092-uftc8inx 4179 11 end end NN cord-010092-uftc8inx 4179 12 of of IN cord-010092-uftc8inx 4179 13 their -PRON- PRP$ cord-010092-uftc8inx 4179 14 training training NN cord-010092-uftc8inx 4179 15 at at IN cord-010092-uftc8inx 4179 16 the the DT cord-010092-uftc8inx 4179 17 higher high JJR cord-010092-uftc8inx 4179 18 Institute Institute NNP cord-010092-uftc8inx 4179 19 of of IN cord-010092-uftc8inx 4179 20 Nursing Nursing NNP cord-010092-uftc8inx 4179 21 Sciences Sciences NNPS cord-010092-uftc8inx 4179 22 . . . cord-010092-uftc8inx 4180 1 The the DT cord-010092-uftc8inx 4180 2 2 2 CD cord-010092-uftc8inx 4180 3 nd nd NNP cord-010092-uftc8inx 4180 4 is be VBZ cord-010092-uftc8inx 4180 5 made make VBN cord-010092-uftc8inx 4180 6 up up RP cord-010092-uftc8inx 4180 7 of of IN cord-010092-uftc8inx 4180 8 50 50 CD cord-010092-uftc8inx 4180 9 nurses nurse NNS cord-010092-uftc8inx 4180 10 working work VBG cord-010092-uftc8inx 4180 11 in in IN cord-010092-uftc8inx 4180 12 5 5 CD cord-010092-uftc8inx 4180 13 university university NN cord-010092-uftc8inx 4180 14 hospitals hospital NNS cord-010092-uftc8inx 4180 15 of of IN cord-010092-uftc8inx 4180 16 Tunis Tunis NNP cord-010092-uftc8inx 4180 17 , , , cord-010092-uftc8inx 4180 18 currently currently RB cord-010092-uftc8inx 4180 19 practicing practice VBG cord-010092-uftc8inx 4180 20 blood blood NN cord-010092-uftc8inx 4180 21 transfusion transfusion NN cord-010092-uftc8inx 4180 22 . . . cord-010092-uftc8inx 4181 1 The the DT cord-010092-uftc8inx 4181 2 evaluation evaluation NN cord-010092-uftc8inx 4181 3 's 's POS cord-010092-uftc8inx 4181 4 tool tool NN cord-010092-uftc8inx 4181 5 used use VBN cord-010092-uftc8inx 4181 6 was be VBD cord-010092-uftc8inx 4181 7 a a DT cord-010092-uftc8inx 4181 8 questionnaire questionnaire NN cord-010092-uftc8inx 4181 9 of of IN cord-010092-uftc8inx 4181 10 15 15 CD cord-010092-uftc8inx 4181 11 simple simple JJ cord-010092-uftc8inx 4181 12 or or CC cord-010092-uftc8inx 4181 13 multiple multiple JJ cord-010092-uftc8inx 4181 14 choice choice NN cord-010092-uftc8inx 4181 15 questions question NNS cord-010092-uftc8inx 4181 16 , , , cord-010092-uftc8inx 4181 17 7 7 CD cord-010092-uftc8inx 4181 18 were be VBD cord-010092-uftc8inx 4181 19 related relate VBN cord-010092-uftc8inx 4181 20 to to IN cord-010092-uftc8inx 4181 21 theoretical theoretical JJ cord-010092-uftc8inx 4181 22 knowledge knowledge NN cord-010092-uftc8inx 4181 23 of of IN cord-010092-uftc8inx 4181 24 labile labile JJ cord-010092-uftc8inx 4181 25 blood blood NN cord-010092-uftc8inx 4181 26 products product NNS cord-010092-uftc8inx 4181 27 and and CC cord-010092-uftc8inx 4181 28 8 8 CD cord-010092-uftc8inx 4181 29 to to IN cord-010092-uftc8inx 4181 30 transfusion transfusion NN cord-010092-uftc8inx 4181 31 practice practice NN cord-010092-uftc8inx 4181 32 . . . cord-010092-uftc8inx 4182 1 Ten ten CD cord-010092-uftc8inx 4182 2 questions question NNS cord-010092-uftc8inx 4182 3 were be VBD cord-010092-uftc8inx 4182 4 considered consider VBN cord-010092-uftc8inx 4182 5 " " `` cord-010092-uftc8inx 4182 6 life life NN cord-010092-uftc8inx 4182 7 - - HYPH cord-010092-uftc8inx 4182 8 threatening threaten VBG cord-010092-uftc8inx 4182 9 " " '' cord-010092-uftc8inx 4182 10 if if IN cord-010092-uftc8inx 4182 11 their -PRON- PRP$ cord-010092-uftc8inx 4182 12 answers answer NNS cord-010092-uftc8inx 4182 13 were be VBD cord-010092-uftc8inx 4182 14 false false JJ cord-010092-uftc8inx 4182 15 . . . cord-010092-uftc8inx 4183 1 A a DT cord-010092-uftc8inx 4183 2 comparative comparative JJ cord-010092-uftc8inx 4183 3 study study NN cord-010092-uftc8inx 4183 4 was be VBD cord-010092-uftc8inx 4183 5 made make VBN cord-010092-uftc8inx 4183 6 between between IN cord-010092-uftc8inx 4183 7 the the DT cord-010092-uftc8inx 4183 8 two two CD cord-010092-uftc8inx 4183 9 groups group NNS cord-010092-uftc8inx 4183 10 . . . cord-010092-uftc8inx 4184 1 Results result NNS cord-010092-uftc8inx 4184 2 : : : cord-010092-uftc8inx 4185 1 The the DT cord-010092-uftc8inx 4185 2 participation participation NN cord-010092-uftc8inx 4185 3 rate rate NN cord-010092-uftc8inx 4185 4 in in IN cord-010092-uftc8inx 4185 5 the the DT cord-010092-uftc8inx 4185 6 survey survey NN cord-010092-uftc8inx 4185 7 was be VBD cord-010092-uftc8inx 4185 8 100 100 CD cord-010092-uftc8inx 4185 9 % % NN cord-010092-uftc8inx 4185 10 . . . cord-010092-uftc8inx 4186 1 The the DT cord-010092-uftc8inx 4186 2 2 2 CD cord-010092-uftc8inx 4186 3 nd nd NNP cord-010092-uftc8inx 4186 4 group group NN cord-010092-uftc8inx 4186 5 participants participant NNS cord-010092-uftc8inx 4186 6 had have VBD cord-010092-uftc8inx 4186 7 an an DT cord-010092-uftc8inx 4186 8 average average JJ cord-010092-uftc8inx 4186 9 seniority seniority NN cord-010092-uftc8inx 4186 10 of of IN cord-010092-uftc8inx 4186 11 9 9 CD cord-010092-uftc8inx 4186 12 years year NNS cord-010092-uftc8inx 4186 13 . . . cord-010092-uftc8inx 4187 1 More More JJR cord-010092-uftc8inx 4187 2 than than IN cord-010092-uftc8inx 4187 3 half half NN cord-010092-uftc8inx 4187 4 of of IN cord-010092-uftc8inx 4187 5 them -PRON- PRP cord-010092-uftc8inx 4187 6 ( ( -LRB- cord-010092-uftc8inx 4187 7 64 64 CD cord-010092-uftc8inx 4187 8 % % NN cord-010092-uftc8inx 4187 9 ) ) -RRB- cord-010092-uftc8inx 4187 10 had have VBD cord-010092-uftc8inx 4187 11 seniority seniority NN cord-010092-uftc8inx 4187 12 of of IN cord-010092-uftc8inx 4187 13 less less JJR cord-010092-uftc8inx 4187 14 than than IN cord-010092-uftc8inx 4187 15 10 10 CD cord-010092-uftc8inx 4187 16 years year NNS cord-010092-uftc8inx 4187 17 . . . cord-010092-uftc8inx 4188 1 Only only RB cord-010092-uftc8inx 4188 2 12 12 CD cord-010092-uftc8inx 4188 3 % % NN cord-010092-uftc8inx 4188 4 had have VBD cord-010092-uftc8inx 4188 5 more more JJR cord-010092-uftc8inx 4188 6 than than IN cord-010092-uftc8inx 4188 7 20 20 CD cord-010092-uftc8inx 4188 8 years year NNS cord-010092-uftc8inx 4188 9 of of IN cord-010092-uftc8inx 4188 10 experience experience NN cord-010092-uftc8inx 4188 11 . . . cord-010092-uftc8inx 4189 1 The the DT cord-010092-uftc8inx 4189 2 rate rate NN cord-010092-uftc8inx 4189 3 of of IN cord-010092-uftc8inx 4189 4 correct correct JJ cord-010092-uftc8inx 4189 5 answers answer NNS cord-010092-uftc8inx 4189 6 for for IN cord-010092-uftc8inx 4189 7 all all DT cord-010092-uftc8inx 4189 8 items item NNS cord-010092-uftc8inx 4189 9 combined combine VBN cord-010092-uftc8inx 4189 10 was be VBD cord-010092-uftc8inx 4189 11 44.4 44.4 CD cord-010092-uftc8inx 4189 12 % % NN cord-010092-uftc8inx 4189 13 for for IN cord-010092-uftc8inx 4189 14 students student NNS cord-010092-uftc8inx 4189 15 versus versus IN cord-010092-uftc8inx 4189 16 42.5 42.5 CD cord-010092-uftc8inx 4189 17 % % NN cord-010092-uftc8inx 4189 18 for for IN cord-010092-uftc8inx 4189 19 practicing practice VBG cord-010092-uftc8inx 4189 20 nurses nurse NNS cord-010092-uftc8inx 4189 21 . . . cord-010092-uftc8inx 4190 1 The the DT cord-010092-uftc8inx 4190 2 theoretical theoretical JJ cord-010092-uftc8inx 4190 3 knowledge knowledge NN cord-010092-uftc8inx 4190 4 part part NN cord-010092-uftc8inx 4190 5 was be VBD cord-010092-uftc8inx 4190 6 more more RBR cord-010092-uftc8inx 4190 7 mastered master VBN cord-010092-uftc8inx 4190 8 in in IN cord-010092-uftc8inx 4190 9 the the DT cord-010092-uftc8inx 4190 10 1 1 CD cord-010092-uftc8inx 4190 11 st st NNP cord-010092-uftc8inx 4190 12 group group NNP cord-010092-uftc8inx 4190 13 than than IN cord-010092-uftc8inx 4190 14 that that DT cord-010092-uftc8inx 4190 15 of of IN cord-010092-uftc8inx 4190 16 practicing practice VBG cord-010092-uftc8inx 4190 17 nurses nurse NNS cord-010092-uftc8inx 4190 18 ( ( -LRB- cord-010092-uftc8inx 4190 19 44.8 44.8 CD cord-010092-uftc8inx 4190 20 % % NN cord-010092-uftc8inx 4190 21 vs vs IN cord-010092-uftc8inx 4190 22 33.4 33.4 CD cord-010092-uftc8inx 4190 23 % % NN cord-010092-uftc8inx 4190 24 of of IN cord-010092-uftc8inx 4190 25 correct correct JJ cord-010092-uftc8inx 4190 26 answers answer NNS cord-010092-uftc8inx 4190 27 ) ) -RRB- cord-010092-uftc8inx 4190 28 . . . cord-010092-uftc8inx 4191 1 On on IN cord-010092-uftc8inx 4191 2 the the DT cord-010092-uftc8inx 4191 3 other other JJ cord-010092-uftc8inx 4191 4 hand hand NN cord-010092-uftc8inx 4191 5 , , , cord-010092-uftc8inx 4191 6 the the DT cord-010092-uftc8inx 4191 7 control control NN cord-010092-uftc8inx 4191 8 of of IN cord-010092-uftc8inx 4191 9 the the DT cord-010092-uftc8inx 4191 10 transfusion transfusion NN cord-010092-uftc8inx 4191 11 act act NN cord-010092-uftc8inx 4191 12 was be VBD cord-010092-uftc8inx 4191 13 better well JJR cord-010092-uftc8inx 4191 14 in in IN cord-010092-uftc8inx 4191 15 2 2 CD cord-010092-uftc8inx 4191 16 nd nd NNP cord-010092-uftc8inx 4191 17 group group NN cord-010092-uftc8inx 4191 18 ( ( -LRB- cord-010092-uftc8inx 4191 19 44 44 CD cord-010092-uftc8inx 4191 20 % % NN cord-010092-uftc8inx 4191 21 vs vs IN cord-010092-uftc8inx 4191 22 50.5 50.5 CD cord-010092-uftc8inx 4191 23 % % NN cord-010092-uftc8inx 4191 24 ) ) -RRB- cord-010092-uftc8inx 4191 25 . . . cord-010092-uftc8inx 4192 1 The the DT cord-010092-uftc8inx 4192 2 overall overall JJ cord-010092-uftc8inx 4192 3 " " `` cord-010092-uftc8inx 4192 4 dangerous dangerous JJ cord-010092-uftc8inx 4192 5 " " '' cord-010092-uftc8inx 4192 6 response response NN cord-010092-uftc8inx 4192 7 rate rate NN cord-010092-uftc8inx 4192 8 was be VBD cord-010092-uftc8inx 4192 9 47 47 CD cord-010092-uftc8inx 4192 10 % % NN cord-010092-uftc8inx 4192 11 for for IN cord-010092-uftc8inx 4192 12 students student NNS cord-010092-uftc8inx 4192 13 and and CC cord-010092-uftc8inx 4192 14 41.7 41.7 CD cord-010092-uftc8inx 4192 15 % % NN cord-010092-uftc8inx 4192 16 for for IN cord-010092-uftc8inx 4192 17 practicing practice VBG cord-010092-uftc8inx 4192 18 nurses nurse NNS cord-010092-uftc8inx 4192 19 . . . cord-010092-uftc8inx 4193 1 False false JJ cord-010092-uftc8inx 4193 2 practical practical JJ cord-010092-uftc8inx 4193 3 knowledge knowledge NN cord-010092-uftc8inx 4193 4 was be VBD cord-010092-uftc8inx 4193 5 more more RBR cord-010092-uftc8inx 4193 6 common common JJ cord-010092-uftc8inx 4193 7 in in IN cord-010092-uftc8inx 4193 8 group group NN cord-010092-uftc8inx 4193 9 1 1 CD cord-010092-uftc8inx 4193 10 ( ( -LRB- cord-010092-uftc8inx 4193 11 59.5 59.5 CD cord-010092-uftc8inx 4193 12 % % NN cord-010092-uftc8inx 4193 13 vs. vs. IN cord-010092-uftc8inx 4193 14 41.5 41.5 CD cord-010092-uftc8inx 4193 15 % % NN cord-010092-uftc8inx 4193 16 ) ) -RRB- cord-010092-uftc8inx 4193 17 . . . cord-010092-uftc8inx 4194 1 Summary Summary NNP cord-010092-uftc8inx 4194 2 / / SYM cord-010092-uftc8inx 4194 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 4194 4 : : : cord-010092-uftc8inx 4195 1 The the DT cord-010092-uftc8inx 4195 2 theoretical theoretical JJ cord-010092-uftc8inx 4195 3 as as RB cord-010092-uftc8inx 4195 4 well well RB cord-010092-uftc8inx 4195 5 as as IN cord-010092-uftc8inx 4195 6 the the DT cord-010092-uftc8inx 4195 7 practical practical JJ cord-010092-uftc8inx 4195 8 knowledge knowledge NN cord-010092-uftc8inx 4195 9 remains remain VBZ cord-010092-uftc8inx 4195 10 not not RB cord-010092-uftc8inx 4195 11 well well RB cord-010092-uftc8inx 4195 12 mastered master VBN cord-010092-uftc8inx 4195 13 by by IN cord-010092-uftc8inx 4195 14 the the DT cord-010092-uftc8inx 4195 15 care care NN cord-010092-uftc8inx 4195 16 staff staff NN cord-010092-uftc8inx 4195 17 . . . cord-010092-uftc8inx 4196 1 Our -PRON- PRP$ cord-010092-uftc8inx 4196 2 study study NN cord-010092-uftc8inx 4196 3 highlighted highlight VBD cord-010092-uftc8inx 4196 4 the the DT cord-010092-uftc8inx 4196 5 best good JJS cord-010092-uftc8inx 4196 6 theoretical theoretical JJ cord-010092-uftc8inx 4196 7 mastery mastery NN cord-010092-uftc8inx 4196 8 for for IN cord-010092-uftc8inx 4196 9 young young JJ cord-010092-uftc8inx 4196 10 students student NNS cord-010092-uftc8inx 4196 11 and and CC cord-010092-uftc8inx 4196 12 practical practical JJ cord-010092-uftc8inx 4196 13 for for IN cord-010092-uftc8inx 4196 14 practicing practice VBG cord-010092-uftc8inx 4196 15 nurses nurse NNS cord-010092-uftc8inx 4196 16 . . . cord-010092-uftc8inx 4197 1 This this DT cord-010092-uftc8inx 4197 2 could could MD cord-010092-uftc8inx 4197 3 be be VB cord-010092-uftc8inx 4197 4 explained explain VBN cord-010092-uftc8inx 4197 5 by by IN cord-010092-uftc8inx 4197 6 the the DT cord-010092-uftc8inx 4197 7 freshness freshness NN cord-010092-uftc8inx 4197 8 of of IN cord-010092-uftc8inx 4197 9 knowledge knowledge NN cord-010092-uftc8inx 4197 10 in in IN cord-010092-uftc8inx 4197 11 the the DT cord-010092-uftc8inx 4197 12 first first JJ cord-010092-uftc8inx 4197 13 group group NN cord-010092-uftc8inx 4197 14 and and CC cord-010092-uftc8inx 4197 15 the the DT cord-010092-uftc8inx 4197 16 daily daily JJ cord-010092-uftc8inx 4197 17 practice practice NN cord-010092-uftc8inx 4197 18 in in IN cord-010092-uftc8inx 4197 19 the the DT cord-010092-uftc8inx 4197 20 second second JJ cord-010092-uftc8inx 4197 21 group group NN cord-010092-uftc8inx 4197 22 . . . cord-010092-uftc8inx 4198 1 Background background NN cord-010092-uftc8inx 4198 2 : : : cord-010092-uftc8inx 4199 1 The the DT cord-010092-uftc8inx 4199 2 European European NNP cord-010092-uftc8inx 4199 3 Commission Commission NNP cord-010092-uftc8inx 4199 4 ( ( -LRB- cord-010092-uftc8inx 4199 5 EC EC NNP cord-010092-uftc8inx 4199 6 ) ) -RRB- cord-010092-uftc8inx 4199 7 Directive Directive NNP cord-010092-uftc8inx 4199 8 2004/33 2004/33 CD cord-010092-uftc8inx 4199 9 / / SYM cord-010092-uftc8inx 4199 10 EC EC NNP cord-010092-uftc8inx 4199 11 on on IN cord-010092-uftc8inx 4199 12 blood blood NN cord-010092-uftc8inx 4199 13 donor donor NN cord-010092-uftc8inx 4199 14 selection selection NN cord-010092-uftc8inx 4199 15 criteria criterion NNS cord-010092-uftc8inx 4199 16 is be VBZ cord-010092-uftc8inx 4199 17 15 15 CD cord-010092-uftc8inx 4199 18 years year NNS cord-010092-uftc8inx 4199 19 old old JJ cord-010092-uftc8inx 4199 20 . . . cord-010092-uftc8inx 4200 1 In in IN cord-010092-uftc8inx 4200 2 the the DT cord-010092-uftc8inx 4200 3 meantime meantime NN cord-010092-uftc8inx 4200 4 , , , cord-010092-uftc8inx 4200 5 knowledge knowledge NN cord-010092-uftc8inx 4200 6 on on IN cord-010092-uftc8inx 4200 7 risks risk NNS cord-010092-uftc8inx 4200 8 related relate VBN cord-010092-uftc8inx 4200 9 to to IN cord-010092-uftc8inx 4200 10 blood blood NN cord-010092-uftc8inx 4200 11 donor donor NN cord-010092-uftc8inx 4200 12 selection selection NN cord-010092-uftc8inx 4200 13 has have VBZ cord-010092-uftc8inx 4200 14 progressed progress VBN cord-010092-uftc8inx 4200 15 and and CC cord-010092-uftc8inx 4200 16 challenged challenge VBD cord-010092-uftc8inx 4200 17 several several JJ cord-010092-uftc8inx 4200 18 obligatory obligatory JJ cord-010092-uftc8inx 4200 19 rules rule NNS cord-010092-uftc8inx 4200 20 . . . cord-010092-uftc8inx 4201 1 TRANSPOSE transpose VB cord-010092-uftc8inx 4201 2 -TRANSfusion -transfusion NN cord-010092-uftc8inx 4201 3 and and CC cord-010092-uftc8inx 4201 4 transplantation transplantation NN cord-010092-uftc8inx 4201 5 : : : cord-010092-uftc8inx 4202 1 PrOtection PrOtection NNP cord-010092-uftc8inx 4202 2 and and CC cord-010092-uftc8inx 4202 3 SElection SElection NNP cord-010092-uftc8inx 4202 4 of of IN cord-010092-uftc8inx 4202 5 donors donor NNS cord-010092-uftc8inx 4202 6 , , , cord-010092-uftc8inx 4202 7 is be VBZ cord-010092-uftc8inx 4202 8 a a DT cord-010092-uftc8inx 4202 9 European European NNP cord-010092-uftc8inx 4202 10 Commission Commission NNP cord-010092-uftc8inx 4202 11 co co NNS cord-010092-uftc8inx 4202 12 - - JJ cord-010092-uftc8inx 4202 13 funded funded JJ cord-010092-uftc8inx 4202 14 project project NN cord-010092-uftc8inx 4202 15 with with IN cord-010092-uftc8inx 4202 16 participation participation NN cord-010092-uftc8inx 4202 17 of of IN cord-010092-uftc8inx 4202 18 more more JJR cord-010092-uftc8inx 4202 19 than than IN cord-010092-uftc8inx 4202 20 24 24 CD cord-010092-uftc8inx 4202 21 stakeholders stakeholder NNS cord-010092-uftc8inx 4202 22 from from IN cord-010092-uftc8inx 4202 23 both both DT cord-010092-uftc8inx 4202 24 not not RB cord-010092-uftc8inx 4202 25 - - HYPH cord-010092-uftc8inx 4202 26 for for IN cord-010092-uftc8inx 4202 27 - - HYPH cord-010092-uftc8inx 4202 28 profit profit NN cord-010092-uftc8inx 4202 29 and and CC cord-010092-uftc8inx 4202 30 private private JJ cord-010092-uftc8inx 4202 31 organizations organization NNS cord-010092-uftc8inx 4202 32 providing provide VBG cord-010092-uftc8inx 4202 33 substances substance NNS cord-010092-uftc8inx 4202 34 of of IN cord-010092-uftc8inx 4202 35 Human Human NNP cord-010092-uftc8inx 4202 36 Origin Origin NNP cord-010092-uftc8inx 4202 37 ( ( -LRB- cord-010092-uftc8inx 4202 38 SoHO SoHO NNP cord-010092-uftc8inx 4202 39 ) ) -RRB- cord-010092-uftc8inx 4202 40 . . . cord-010092-uftc8inx 4203 1 The the DT cord-010092-uftc8inx 4203 2 project project NN cord-010092-uftc8inx 4203 3 aims aim VBZ cord-010092-uftc8inx 4203 4 to to TO cord-010092-uftc8inx 4203 5 provide provide VB cord-010092-uftc8inx 4203 6 evidence evidence NN cord-010092-uftc8inx 4203 7 - - HYPH cord-010092-uftc8inx 4203 8 based base VBN cord-010092-uftc8inx 4203 9 donor donor NN cord-010092-uftc8inx 4203 10 selection selection NN cord-010092-uftc8inx 4203 11 criteria criterion NNS cord-010092-uftc8inx 4203 12 and and CC cord-010092-uftc8inx 4203 13 guiding guide VBG cord-010092-uftc8inx 4203 14 principles principle NNS cord-010092-uftc8inx 4203 15 for for IN cord-010092-uftc8inx 4203 16 risk risk NN cord-010092-uftc8inx 4203 17 assessment assessment NN cord-010092-uftc8inx 4203 18 of of IN cord-010092-uftc8inx 4203 19 threats threat NNS cord-010092-uftc8inx 4203 20 to to IN cord-010092-uftc8inx 4203 21 the the DT cord-010092-uftc8inx 4203 22 safety safety NN cord-010092-uftc8inx 4203 23 of of IN cord-010092-uftc8inx 4203 24 SoHO SoHO NNP cord-010092-uftc8inx 4203 25 . . . cord-010092-uftc8inx 4204 1 As as IN cord-010092-uftc8inx 4204 2 part part NN cord-010092-uftc8inx 4204 3 of of IN cord-010092-uftc8inx 4204 4 this this DT cord-010092-uftc8inx 4204 5 work work NN cord-010092-uftc8inx 4204 6 , , , cord-010092-uftc8inx 4204 7 an an DT cord-010092-uftc8inx 4204 8 inventory inventory NN cord-010092-uftc8inx 4204 9 of of IN cord-010092-uftc8inx 4204 10 current current JJ cord-010092-uftc8inx 4204 11 blood blood NN cord-010092-uftc8inx 4204 12 donor donor NN cord-010092-uftc8inx 4204 13 selection selection NN cord-010092-uftc8inx 4204 14 criteria criterion NNS cord-010092-uftc8inx 4204 15 in in IN cord-010092-uftc8inx 4204 16 Europe Europe NNP cord-010092-uftc8inx 4204 17 and and CC cord-010092-uftc8inx 4204 18 an an DT cord-010092-uftc8inx 4204 19 evaluation evaluation NN cord-010092-uftc8inx 4204 20 of of IN cord-010092-uftc8inx 4204 21 the the DT cord-010092-uftc8inx 4204 22 evidence evidence NN cord-010092-uftc8inx 4204 23 behind behind IN cord-010092-uftc8inx 4204 24 current current JJ cord-010092-uftc8inx 4204 25 practice practice NN cord-010092-uftc8inx 4204 26 was be VBD cord-010092-uftc8inx 4204 27 performed perform VBN cord-010092-uftc8inx 4204 28 by by IN cord-010092-uftc8inx 4204 29 experts expert NNS cord-010092-uftc8inx 4204 30 working work VBG cord-010092-uftc8inx 4204 31 on on IN cord-010092-uftc8inx 4204 32 this this DT cord-010092-uftc8inx 4204 33 project project NN cord-010092-uftc8inx 4204 34 . . . cord-010092-uftc8inx 4205 1 Aims aim VBZ cord-010092-uftc8inx 4205 2 : : : cord-010092-uftc8inx 4205 3 To to TO cord-010092-uftc8inx 4205 4 identify identify VB cord-010092-uftc8inx 4205 5 the the DT cord-010092-uftc8inx 4205 6 gap gap NN cord-010092-uftc8inx 4205 7 between between IN cord-010092-uftc8inx 4205 8 the the DT cord-010092-uftc8inx 4205 9 EC EC NNP cord-010092-uftc8inx 4205 10 Directive Directive NNP cord-010092-uftc8inx 4205 11 2004/33 2004/33 CD cord-010092-uftc8inx 4205 12 / / SYM cord-010092-uftc8inx 4205 13 EC EC NNP cord-010092-uftc8inx 4205 14 on on IN cord-010092-uftc8inx 4205 15 whole whole JJ cord-010092-uftc8inx 4205 16 blood blood NN cord-010092-uftc8inx 4205 17 donor donor NN cord-010092-uftc8inx 4205 18 selection selection NN cord-010092-uftc8inx 4205 19 criteria criterion NNS cord-010092-uftc8inx 4205 20 and and CC cord-010092-uftc8inx 4205 21 a a DT cord-010092-uftc8inx 4205 22 current current JJ cord-010092-uftc8inx 4205 23 evaluation evaluation NN cord-010092-uftc8inx 4205 24 of of IN cord-010092-uftc8inx 4205 25 the the DT cord-010092-uftc8inx 4205 26 clinical clinical JJ cord-010092-uftc8inx 4205 27 relevance relevance NN cord-010092-uftc8inx 4205 28 of of IN cord-010092-uftc8inx 4205 29 the the DT cord-010092-uftc8inx 4205 30 criteria criterion NNS cord-010092-uftc8inx 4205 31 based base VBN cord-010092-uftc8inx 4205 32 on on IN cord-010092-uftc8inx 4205 33 scientific scientific JJ cord-010092-uftc8inx 4205 34 literature literature NN cord-010092-uftc8inx 4205 35 by by IN cord-010092-uftc8inx 4205 36 a a DT cord-010092-uftc8inx 4205 37 panel panel NN cord-010092-uftc8inx 4205 38 of of IN cord-010092-uftc8inx 4205 39 European european JJ cord-010092-uftc8inx 4205 40 experts expert NNS cord-010092-uftc8inx 4205 41 within within IN cord-010092-uftc8inx 4205 42 the the DT cord-010092-uftc8inx 4205 43 Transpose transpose NN cord-010092-uftc8inx 4205 44 project project NN cord-010092-uftc8inx 4205 45 . . . cord-010092-uftc8inx 4206 1 Methods method NNS cord-010092-uftc8inx 4206 2 : : : cord-010092-uftc8inx 4207 1 In in IN cord-010092-uftc8inx 4207 2 2018 2018 CD cord-010092-uftc8inx 4207 3 , , , cord-010092-uftc8inx 4207 4 we -PRON- PRP cord-010092-uftc8inx 4207 5 performed perform VBD cord-010092-uftc8inx 4207 6 an an DT cord-010092-uftc8inx 4207 7 inventory inventory NN cord-010092-uftc8inx 4207 8 of of IN cord-010092-uftc8inx 4207 9 blood blood NN cord-010092-uftc8inx 4207 10 donor donor NN cord-010092-uftc8inx 4207 11 and and CC cord-010092-uftc8inx 4207 12 transfusion transfusion NN cord-010092-uftc8inx 4207 13 recipient recipient NN cord-010092-uftc8inx 4207 14 risks risk NNS cord-010092-uftc8inx 4207 15 in in IN cord-010092-uftc8inx 4207 16 participating participate VBG cord-010092-uftc8inx 4207 17 European european JJ cord-010092-uftc8inx 4207 18 countries country NNS cord-010092-uftc8inx 4207 19 . . . cord-010092-uftc8inx 4208 1 Project project NN cord-010092-uftc8inx 4208 2 members member NNS cord-010092-uftc8inx 4208 3 were be VBD cord-010092-uftc8inx 4208 4 asked ask VBN cord-010092-uftc8inx 4208 5 to to TO cord-010092-uftc8inx 4208 6 provide provide VB cord-010092-uftc8inx 4208 7 the the DT cord-010092-uftc8inx 4208 8 existing exist VBG cord-010092-uftc8inx 4208 9 donor donor NN cord-010092-uftc8inx 4208 10 selection selection NN cord-010092-uftc8inx 4208 11 criteria criterion NNS cord-010092-uftc8inx 4208 12 related relate VBN cord-010092-uftc8inx 4208 13 to to IN cord-010092-uftc8inx 4208 14 these these DT cord-010092-uftc8inx 4208 15 risks risk NNS cord-010092-uftc8inx 4208 16 and and CC cord-010092-uftc8inx 4208 17 to to TO cord-010092-uftc8inx 4208 18 carry carry VB cord-010092-uftc8inx 4208 19 out out RP cord-010092-uftc8inx 4208 20 a a DT cord-010092-uftc8inx 4208 21 risk risk NN cord-010092-uftc8inx 4208 22 - - HYPH cord-010092-uftc8inx 4208 23 based base VBN cord-010092-uftc8inx 4208 24 evaluation evaluation NN cord-010092-uftc8inx 4208 25 for for IN cord-010092-uftc8inx 4208 26 each each DT cord-010092-uftc8inx 4208 27 of of IN cord-010092-uftc8inx 4208 28 them -PRON- PRP cord-010092-uftc8inx 4208 29 . . . cord-010092-uftc8inx 4209 1 The the DT cord-010092-uftc8inx 4209 2 evaluation evaluation NN cord-010092-uftc8inx 4209 3 was be VBD cord-010092-uftc8inx 4209 4 based base VBN cord-010092-uftc8inx 4209 5 on on IN cord-010092-uftc8inx 4209 6 the the DT cord-010092-uftc8inx 4209 7 available available JJ cord-010092-uftc8inx 4209 8 scientific scientific JJ cord-010092-uftc8inx 4209 9 literature literature NN cord-010092-uftc8inx 4209 10 and and CC cord-010092-uftc8inx 4209 11 on on IN cord-010092-uftc8inx 4209 12 a a DT cord-010092-uftc8inx 4209 13 risk risk NN cord-010092-uftc8inx 4209 14 assessment assessment NN cord-010092-uftc8inx 4209 15 template template NN cord-010092-uftc8inx 4209 16 based base VBN cord-010092-uftc8inx 4209 17 on on IN cord-010092-uftc8inx 4209 18 the the DT cord-010092-uftc8inx 4209 19 ABO ABO NNP cord-010092-uftc8inx 4209 20 Risk Risk NNP cord-010092-uftc8inx 4209 21 - - HYPH cord-010092-uftc8inx 4209 22 Based Based NNP cord-010092-uftc8inx 4209 23 Decision decision NN cord-010092-uftc8inx 4209 24 - - HYPH cord-010092-uftc8inx 4209 25 Making Making NNP cord-010092-uftc8inx 4209 26 Framework Framework NNP cord-010092-uftc8inx 4209 27 , , , cord-010092-uftc8inx 4209 28 developed develop VBN cord-010092-uftc8inx 4209 29 by by IN cord-010092-uftc8inx 4209 30 Transpose transpose NN cord-010092-uftc8inx 4209 31 . . . cord-010092-uftc8inx 4210 1 All all DT cord-010092-uftc8inx 4210 2 risks risk NNS cord-010092-uftc8inx 4210 3 with with IN cord-010092-uftc8inx 4210 4 divergent divergent JJ cord-010092-uftc8inx 4210 5 assessments assessment NNS cord-010092-uftc8inx 4210 6 within within IN cord-010092-uftc8inx 4210 7 the the DT cord-010092-uftc8inx 4210 8 panel panel NN cord-010092-uftc8inx 4210 9 were be VBD cord-010092-uftc8inx 4210 10 resolved resolve VBN cord-010092-uftc8inx 4210 11 through through IN cord-010092-uftc8inx 4210 12 discussion discussion NN cord-010092-uftc8inx 4210 13 ; ; : cord-010092-uftc8inx 4210 14 in in IN cord-010092-uftc8inx 4210 15 all all DT cord-010092-uftc8inx 4210 16 cases case NNS cord-010092-uftc8inx 4210 17 an an DT cord-010092-uftc8inx 4210 18 expert expert JJ cord-010092-uftc8inx 4210 19 consensus consensus NN cord-010092-uftc8inx 4210 20 was be VBD cord-010092-uftc8inx 4210 21 established establish VBN cord-010092-uftc8inx 4210 22 . . . cord-010092-uftc8inx 4211 1 Subsequently subsequently RB cord-010092-uftc8inx 4211 2 we -PRON- PRP cord-010092-uftc8inx 4211 3 compared compare VBD cord-010092-uftc8inx 4211 4 the the DT cord-010092-uftc8inx 4211 5 results result NNS cord-010092-uftc8inx 4211 6 with with IN cord-010092-uftc8inx 4211 7 the the DT cord-010092-uftc8inx 4211 8 content content NN cord-010092-uftc8inx 4211 9 of of IN cord-010092-uftc8inx 4211 10 the the DT cord-010092-uftc8inx 4211 11 EC EC NNP cord-010092-uftc8inx 4211 12 Directive Directive NNP cord-010092-uftc8inx 4211 13 2004/33 2004/33 NNP cord-010092-uftc8inx 4211 14 / / SYM cord-010092-uftc8inx 4211 15 EC EC NNP cord-010092-uftc8inx 4211 16 for for IN cord-010092-uftc8inx 4211 17 every every DT cord-010092-uftc8inx 4211 18 risk risk NN cord-010092-uftc8inx 4211 19 , , , cord-010092-uftc8inx 4211 20 thereby thereby RB cord-010092-uftc8inx 4211 21 identifying identify VBG cord-010092-uftc8inx 4211 22 discrepancies discrepancy NNS cord-010092-uftc8inx 4211 23 and and CC cord-010092-uftc8inx 4211 24 missing miss VBG cord-010092-uftc8inx 4211 25 items item NNS cord-010092-uftc8inx 4211 26 in in IN cord-010092-uftc8inx 4211 27 the the DT cord-010092-uftc8inx 4211 28 Directive Directive NNP cord-010092-uftc8inx 4211 29 . . . cord-010092-uftc8inx 4212 1 Results result NNS cord-010092-uftc8inx 4212 2 : : : cord-010092-uftc8inx 4213 1 The the DT cord-010092-uftc8inx 4213 2 panel panel NN cord-010092-uftc8inx 4213 3 identified identify VBD cord-010092-uftc8inx 4213 4 64 64 CD cord-010092-uftc8inx 4213 5 risks risk NNS cord-010092-uftc8inx 4213 6 considered consider VBN cord-010092-uftc8inx 4213 7 to to TO cord-010092-uftc8inx 4213 8 be be VB cord-010092-uftc8inx 4213 9 significant significant JJ cord-010092-uftc8inx 4213 10 , , , cord-010092-uftc8inx 4213 11 distributed distribute VBN cord-010092-uftc8inx 4213 12 between between IN cord-010092-uftc8inx 4213 13 donors donor NNS cord-010092-uftc8inx 4213 14 and and CC cord-010092-uftc8inx 4213 15 recipients recipient NNS cord-010092-uftc8inx 4213 16 . . . cord-010092-uftc8inx 4214 1 For for IN cord-010092-uftc8inx 4214 2 35/64 35/64 CD cord-010092-uftc8inx 4214 3 ( ( -LRB- cord-010092-uftc8inx 4214 4 55 55 CD cord-010092-uftc8inx 4214 5 % % NN cord-010092-uftc8inx 4214 6 ) ) -RRB- cord-010092-uftc8inx 4214 7 of of IN cord-010092-uftc8inx 4214 8 them -PRON- PRP cord-010092-uftc8inx 4214 9 the the DT cord-010092-uftc8inx 4214 10 expert expert NN cord-010092-uftc8inx 4214 11 evaluation evaluation NN cord-010092-uftc8inx 4214 12 deviated deviate VBN cord-010092-uftc8inx 4214 13 from from IN cord-010092-uftc8inx 4214 14 the the DT cord-010092-uftc8inx 4214 15 content content NN cord-010092-uftc8inx 4214 16 of of IN cord-010092-uftc8inx 4214 17 the the DT cord-010092-uftc8inx 4214 18 EC EC NNP cord-010092-uftc8inx 4214 19 Directive Directive NNP cord-010092-uftc8inx 4214 20 , , , cord-010092-uftc8inx 4214 21 or or CC cord-010092-uftc8inx 4214 22 the the DT cord-010092-uftc8inx 4214 23 EC EC NNP cord-010092-uftc8inx 4214 24 Directive Directive NNP cord-010092-uftc8inx 4214 25 provided provide VBD cord-010092-uftc8inx 4214 26 no no DT cord-010092-uftc8inx 4214 27 information information NN cord-010092-uftc8inx 4214 28 about about IN cord-010092-uftc8inx 4214 29 the the DT cord-010092-uftc8inx 4214 30 decision decision NN cord-010092-uftc8inx 4214 31 making make VBG cord-010092-uftc8inx 4214 32 . . . cord-010092-uftc8inx 4215 1 In in IN cord-010092-uftc8inx 4215 2 particular particular JJ cord-010092-uftc8inx 4215 3 , , , cord-010092-uftc8inx 4215 4 a a DT cord-010092-uftc8inx 4215 5 discrepancy discrepancy NN cord-010092-uftc8inx 4215 6 was be VBD cord-010092-uftc8inx 4215 7 observed observe VBN cord-010092-uftc8inx 4215 8 for for IN cord-010092-uftc8inx 4215 9 9/20 9/20 CD cord-010092-uftc8inx 4215 10 criteria criterion NNS cord-010092-uftc8inx 4215 11 concerning concern VBG cord-010092-uftc8inx 4215 12 general general JJ cord-010092-uftc8inx 4215 13 health health NN cord-010092-uftc8inx 4215 14 and and CC cord-010092-uftc8inx 4215 15 medication medication NN cord-010092-uftc8inx 4215 16 , , , cord-010092-uftc8inx 4215 17 12/22 12/22 CD cord-010092-uftc8inx 4215 18 for for IN cord-010092-uftc8inx 4215 19 transfusion transfusion NN cord-010092-uftc8inx 4215 20 transmissible transmissible JJ cord-010092-uftc8inx 4215 21 infections infection NNS cord-010092-uftc8inx 4215 22 , , , cord-010092-uftc8inx 4215 23 10/13 10/13 CD cord-010092-uftc8inx 4215 24 for for IN cord-010092-uftc8inx 4215 25 high high JJ cord-010092-uftc8inx 4215 26 - - HYPH cord-010092-uftc8inx 4215 27 risk risk NN cord-010092-uftc8inx 4215 28 behaviour behaviour NN cord-010092-uftc8inx 4215 29 and and CC cord-010092-uftc8inx 4215 30 travel travel NN cord-010092-uftc8inx 4215 31 , , , cord-010092-uftc8inx 4215 32 and and CC cord-010092-uftc8inx 4215 33 4/9 4/9 CD cord-010092-uftc8inx 4215 34 for for IN cord-010092-uftc8inx 4215 35 other other JJ cord-010092-uftc8inx 4215 36 diseases disease NNS cord-010092-uftc8inx 4215 37 . . . cord-010092-uftc8inx 4216 1 Summary Summary NNP cord-010092-uftc8inx 4216 2 / / SYM cord-010092-uftc8inx 4216 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 4216 4 : : : cord-010092-uftc8inx 4217 1 Our -PRON- PRP$ cord-010092-uftc8inx 4217 2 results result NNS cord-010092-uftc8inx 4217 3 highlight highlight VBP cord-010092-uftc8inx 4217 4 a a DT cord-010092-uftc8inx 4217 5 significant significant JJ cord-010092-uftc8inx 4217 6 gap gap NN cord-010092-uftc8inx 4217 7 between between IN cord-010092-uftc8inx 4217 8 the the DT cord-010092-uftc8inx 4217 9 whole whole JJ cord-010092-uftc8inx 4217 10 blood blood NN cord-010092-uftc8inx 4217 11 donor donor NN cord-010092-uftc8inx 4217 12 selection selection NN cord-010092-uftc8inx 4217 13 criteria criterion NNS cord-010092-uftc8inx 4217 14 stated state VBN cord-010092-uftc8inx 4217 15 in in IN cord-010092-uftc8inx 4217 16 the the DT cord-010092-uftc8inx 4217 17 EC EC NNP cord-010092-uftc8inx 4217 18 Directive Directive NNP cord-010092-uftc8inx 4217 19 2004/33 2004/33 NNP cord-010092-uftc8inx 4217 20 / / SYM cord-010092-uftc8inx 4217 21 EC EC NNP cord-010092-uftc8inx 4217 22 and and CC cord-010092-uftc8inx 4217 23 the the DT cord-010092-uftc8inx 4217 24 scientific scientific JJ cord-010092-uftc8inx 4217 25 evaluation evaluation NN cord-010092-uftc8inx 4217 26 performed perform VBN cord-010092-uftc8inx 4217 27 by by IN cord-010092-uftc8inx 4217 28 a a DT cord-010092-uftc8inx 4217 29 panel panel NN cord-010092-uftc8inx 4217 30 of of IN cord-010092-uftc8inx 4217 31 Transpose transpose NN cord-010092-uftc8inx 4217 32 participating participate VBG cord-010092-uftc8inx 4217 33 experts expert NNS cord-010092-uftc8inx 4217 34 . . . cord-010092-uftc8inx 4218 1 This this DT cord-010092-uftc8inx 4218 2 gap gap NN cord-010092-uftc8inx 4218 3 includes include VBZ cord-010092-uftc8inx 4218 4 both both DT cord-010092-uftc8inx 4218 5 new new JJ cord-010092-uftc8inx 4218 6 risks risk NNS cord-010092-uftc8inx 4218 7 not not RB cord-010092-uftc8inx 4218 8 addressed address VBN cord-010092-uftc8inx 4218 9 in in IN cord-010092-uftc8inx 4218 10 the the DT cord-010092-uftc8inx 4218 11 EC EC NNP cord-010092-uftc8inx 4218 12 Directive Directive NNP cord-010092-uftc8inx 4218 13 and and CC cord-010092-uftc8inx 4218 14 addressed address VBD cord-010092-uftc8inx 4218 15 risks risk NNS cord-010092-uftc8inx 4218 16 that that WDT cord-010092-uftc8inx 4218 17 are be VBP cord-010092-uftc8inx 4218 18 however however RB cord-010092-uftc8inx 4218 19 evaluated evaluate VBN cord-010092-uftc8inx 4218 20 differently differently RB cord-010092-uftc8inx 4218 21 . . . cord-010092-uftc8inx 4219 1 This this DT cord-010092-uftc8inx 4219 2 involves involve VBZ cord-010092-uftc8inx 4219 3 both both CC cord-010092-uftc8inx 4219 4 blood blood NN cord-010092-uftc8inx 4219 5 donor donor NN cord-010092-uftc8inx 4219 6 and and CC cord-010092-uftc8inx 4219 7 transfusion transfusion NN cord-010092-uftc8inx 4219 8 recipient recipient NN cord-010092-uftc8inx 4219 9 safety safety NN cord-010092-uftc8inx 4219 10 , , , cord-010092-uftc8inx 4219 11 and and CC cord-010092-uftc8inx 4219 12 various various JJ cord-010092-uftc8inx 4219 13 medical medical JJ cord-010092-uftc8inx 4219 14 and and CC cord-010092-uftc8inx 4219 15 epidemiological epidemiological JJ cord-010092-uftc8inx 4219 16 topics topic NNS cord-010092-uftc8inx 4219 17 covering cover VBG cord-010092-uftc8inx 4219 18 several several JJ cord-010092-uftc8inx 4219 19 aspects aspect NNS cord-010092-uftc8inx 4219 20 of of IN cord-010092-uftc8inx 4219 21 the the DT cord-010092-uftc8inx 4219 22 blood blood NN cord-010092-uftc8inx 4219 23 donation donation NN cord-010092-uftc8inx 4219 24 criteria criterion NNS cord-010092-uftc8inx 4219 25 . . . cord-010092-uftc8inx 4220 1 We -PRON- PRP cord-010092-uftc8inx 4220 2 strongly strongly RB cord-010092-uftc8inx 4220 3 recommend recommend VBP cord-010092-uftc8inx 4220 4 a a DT cord-010092-uftc8inx 4220 5 change change NN cord-010092-uftc8inx 4220 6 in in IN cord-010092-uftc8inx 4220 7 the the DT cord-010092-uftc8inx 4220 8 European european JJ cord-010092-uftc8inx 4220 9 legislation legislation NN cord-010092-uftc8inx 4220 10 , , , cord-010092-uftc8inx 4220 11 allowing allow VBG cord-010092-uftc8inx 4220 12 a a DT cord-010092-uftc8inx 4220 13 procedure procedure NN cord-010092-uftc8inx 4220 14 to to TO cord-010092-uftc8inx 4220 15 guarantee guarantee VB cord-010092-uftc8inx 4220 16 that that IN cord-010092-uftc8inx 4220 17 blood blood NN cord-010092-uftc8inx 4220 18 donor donor NN cord-010092-uftc8inx 4220 19 selection selection NN cord-010092-uftc8inx 4220 20 criteria criterion NNS cord-010092-uftc8inx 4220 21 are be VBP cord-010092-uftc8inx 4220 22 updated update VBN cord-010092-uftc8inx 4220 23 regularly regularly RB cord-010092-uftc8inx 4220 24 within within IN cord-010092-uftc8inx 4220 25 the the DT cord-010092-uftc8inx 4220 26 framework framework NN cord-010092-uftc8inx 4220 27 of of IN cord-010092-uftc8inx 4220 28 the the DT cord-010092-uftc8inx 4220 29 European european JJ cord-010092-uftc8inx 4220 30 institutions institution NNS cord-010092-uftc8inx 4220 31 , , , cord-010092-uftc8inx 4220 32 to to TO cord-010092-uftc8inx 4220 33 keep keep VB cord-010092-uftc8inx 4220 34 aligned align VBN cord-010092-uftc8inx 4220 35 with with IN cord-010092-uftc8inx 4220 36 scientific scientific JJ cord-010092-uftc8inx 4220 37 progress progress NN cord-010092-uftc8inx 4220 38 , , , cord-010092-uftc8inx 4220 39 epidemiology epidemiology NN cord-010092-uftc8inx 4220 40 and and CC cord-010092-uftc8inx 4220 41 changes change NNS cord-010092-uftc8inx 4220 42 in in IN cord-010092-uftc8inx 4220 43 medical medical JJ cord-010092-uftc8inx 4220 44 practice practice NN cord-010092-uftc8inx 4220 45 , , , cord-010092-uftc8inx 4220 46 in in IN cord-010092-uftc8inx 4220 47 order order NN cord-010092-uftc8inx 4220 48 to to TO cord-010092-uftc8inx 4220 49 enable enable VB cord-010092-uftc8inx 4220 50 an an DT cord-010092-uftc8inx 4220 51 updated update VBN cord-010092-uftc8inx 4220 52 risk risk NN cord-010092-uftc8inx 4220 53 - - HYPH cord-010092-uftc8inx 4220 54 and and CC cord-010092-uftc8inx 4220 55 evidence evidence NN cord-010092-uftc8inx 4220 56 - - HYPH cord-010092-uftc8inx 4220 57 based base VBN cord-010092-uftc8inx 4220 58 framework framework NN cord-010092-uftc8inx 4220 59 for for IN cord-010092-uftc8inx 4220 60 donor donor NN cord-010092-uftc8inx 4220 61 selection selection NN cord-010092-uftc8inx 4220 62 criteria criterion NNS cord-010092-uftc8inx 4220 63 . . . cord-010092-uftc8inx 4221 1 The the DT cord-010092-uftc8inx 4221 2 risk risk NN cord-010092-uftc8inx 4221 3 - - HYPH cord-010092-uftc8inx 4221 4 assessment assessment NN cord-010092-uftc8inx 4221 5 method method NN cord-010092-uftc8inx 4221 6 elaborated elaborate VBN cord-010092-uftc8inx 4221 7 in in IN cord-010092-uftc8inx 4221 8 the the DT cord-010092-uftc8inx 4221 9 TRANSPOSE TRANSPOSE NNP cord-010092-uftc8inx 4221 10 Project Project NNP cord-010092-uftc8inx 4221 11 is be VBZ cord-010092-uftc8inx 4221 12 a a DT cord-010092-uftc8inx 4221 13 valuable valuable JJ cord-010092-uftc8inx 4221 14 instrument instrument NN cord-010092-uftc8inx 4221 15 for for IN cord-010092-uftc8inx 4221 16 this this DT cord-010092-uftc8inx 4221 17 purpose purpose NN cord-010092-uftc8inx 4221 18 . . . cord-010092-uftc8inx 4222 1 Background background NN cord-010092-uftc8inx 4222 2 : : : cord-010092-uftc8inx 4223 1 The the DT cord-010092-uftc8inx 4223 2 Brazilian Brazilian NNP cord-010092-uftc8inx 4223 3 Health Health NNP cord-010092-uftc8inx 4223 4 Regulatory Regulatory NNP cord-010092-uftc8inx 4223 5 Agency Agency NNP cord-010092-uftc8inx 4223 6 -Anvisa -anvisa NN cord-010092-uftc8inx 4223 7 has have VBZ cord-010092-uftc8inx 4223 8 developed develop VBN cord-010092-uftc8inx 4223 9 the the DT cord-010092-uftc8inx 4223 10 Method Method NNP cord-010092-uftc8inx 4223 11 for for IN cord-010092-uftc8inx 4223 12 Assessment Assessment NNP cord-010092-uftc8inx 4223 13 of of IN cord-010092-uftc8inx 4223 14 Potential Potential NNP cord-010092-uftc8inx 4223 15 Risk Risk NNP cord-010092-uftc8inx 4223 16 in in IN cord-010092-uftc8inx 4223 17 Hemotherapy Hemotherapy NNP cord-010092-uftc8inx 4223 18 Services Services NNP cord-010092-uftc8inx 4223 19 ( ( -LRB- cord-010092-uftc8inx 4223 20 MARPSH MARPSH NNP cord-010092-uftc8inx 4223 21 ) ) -RRB- cord-010092-uftc8inx 4223 22 which which WDT cord-010092-uftc8inx 4223 23 is be VBZ cord-010092-uftc8inx 4223 24 based base VBN cord-010092-uftc8inx 4223 25 on on IN cord-010092-uftc8inx 4223 26 the the DT cord-010092-uftc8inx 4223 27 data datum NNS cord-010092-uftc8inx 4223 28 collected collect VBN cord-010092-uftc8inx 4223 29 during during IN cord-010092-uftc8inx 4223 30 the the DT cord-010092-uftc8inx 4223 31 inspections inspection NNS cord-010092-uftc8inx 4223 32 of of IN cord-010092-uftc8inx 4223 33 blood blood NN cord-010092-uftc8inx 4223 34 services service NNS cord-010092-uftc8inx 4223 35 carried carry VBN cord-010092-uftc8inx 4223 36 out out RP cord-010092-uftc8inx 4223 37 by by IN cord-010092-uftc8inx 4223 38 regulatory regulatory JJ cord-010092-uftc8inx 4223 39 authorities authority NNS cord-010092-uftc8inx 4223 40 . . . cord-010092-uftc8inx 4224 1 Using use VBG cord-010092-uftc8inx 4224 2 MARPSH MARPSH NNP cord-010092-uftc8inx 4224 3 any any DT cord-010092-uftc8inx 4224 4 blood blood NN cord-010092-uftc8inx 4224 5 service service NN cord-010092-uftc8inx 4224 6 can can MD cord-010092-uftc8inx 4224 7 be be VB cord-010092-uftc8inx 4224 8 classified classify VBN cord-010092-uftc8inx 4224 9 in in IN cord-010092-uftc8inx 4224 10 one one CD cord-010092-uftc8inx 4224 11 of of IN cord-010092-uftc8inx 4224 12 5 5 CD cord-010092-uftc8inx 4224 13 possible possible JJ cord-010092-uftc8inx 4224 14 potential potential JJ cord-010092-uftc8inx 4224 15 risk risk NN cord-010092-uftc8inx 4224 16 categories category NNS cord-010092-uftc8inx 4224 17 : : : cord-010092-uftc8inx 4224 18 High high RB cord-010092-uftc8inx 4224 19 , , , cord-010092-uftc8inx 4224 20 Medium Medium NNP cord-010092-uftc8inx 4224 21 - - HYPH cord-010092-uftc8inx 4224 22 High High NNP cord-010092-uftc8inx 4224 23 , , , cord-010092-uftc8inx 4224 24 Medium Medium NNP cord-010092-uftc8inx 4224 25 , , , cord-010092-uftc8inx 4224 26 Medium Medium NNP cord-010092-uftc8inx 4224 27 - - HYPH cord-010092-uftc8inx 4224 28 Low Low NNP cord-010092-uftc8inx 4224 29 and and CC cord-010092-uftc8inx 4224 30 Low Low NNP cord-010092-uftc8inx 4224 31 Risk Risk NNP cord-010092-uftc8inx 4224 32 . . . cord-010092-uftc8inx 4225 1 Each each DT cord-010092-uftc8inx 4225 2 category category NN cord-010092-uftc8inx 4225 3 represents represent VBZ cord-010092-uftc8inx 4225 4 a a DT cord-010092-uftc8inx 4225 5 different different JJ cord-010092-uftc8inx 4225 6 potential potential JJ cord-010092-uftc8inx 4225 7 risk risk NN cord-010092-uftc8inx 4225 8 level level NN cord-010092-uftc8inx 4225 9 , , , cord-010092-uftc8inx 4225 10 according accord VBG cord-010092-uftc8inx 4225 11 to to IN cord-010092-uftc8inx 4225 12 the the DT cord-010092-uftc8inx 4225 13 proportion proportion NN cord-010092-uftc8inx 4225 14 of of IN cord-010092-uftc8inx 4225 15 compliance compliance NN cord-010092-uftc8inx 4225 16 with with IN cord-010092-uftc8inx 4225 17 the the DT cord-010092-uftc8inx 4225 18 established establish VBN cord-010092-uftc8inx 4225 19 regulatory regulatory JJ cord-010092-uftc8inx 4225 20 requirements requirement NNS cord-010092-uftc8inx 4225 21 . . . cord-010092-uftc8inx 4226 1 MARPSH MARPSH NNP cord-010092-uftc8inx 4226 2 has have VBZ cord-010092-uftc8inx 4226 3 been be VBN cord-010092-uftc8inx 4226 4 used use VBN cord-010092-uftc8inx 4226 5 since since IN cord-010092-uftc8inx 4226 6 2007 2007 CD cord-010092-uftc8inx 4226 7 , , , cord-010092-uftc8inx 4226 8 showing show VBG cord-010092-uftc8inx 4226 9 a a DT cord-010092-uftc8inx 4226 10 trend trend NN cord-010092-uftc8inx 4226 11 of of IN cord-010092-uftc8inx 4226 12 risk risk NN cord-010092-uftc8inx 4226 13 reduction reduction NN cord-010092-uftc8inx 4226 14 on on IN cord-010092-uftc8inx 4226 15 blood blood NN cord-010092-uftc8inx 4226 16 services service NNS cord-010092-uftc8inx 4226 17 evaluated evaluate VBD cord-010092-uftc8inx 4226 18 all all RB cord-010092-uftc8inx 4226 19 over over IN cord-010092-uftc8inx 4226 20 the the DT cord-010092-uftc8inx 4226 21 country country NN cord-010092-uftc8inx 4226 22 . . . cord-010092-uftc8inx 4227 1 Aims aim VBZ cord-010092-uftc8inx 4227 2 : : : cord-010092-uftc8inx 4228 1 This this DT cord-010092-uftc8inx 4228 2 work work NN cord-010092-uftc8inx 4228 3 aims aim VBZ cord-010092-uftc8inx 4228 4 to to TO cord-010092-uftc8inx 4228 5 describe describe VB cord-010092-uftc8inx 4228 6 the the DT cord-010092-uftc8inx 4228 7 utilization utilization NN cord-010092-uftc8inx 4228 8 of of IN cord-010092-uftc8inx 4228 9 MARPSH MARPSH NNP cord-010092-uftc8inx 4228 10 as as IN cord-010092-uftc8inx 4228 11 a a DT cord-010092-uftc8inx 4228 12 tool tool NN cord-010092-uftc8inx 4228 13 for for IN cord-010092-uftc8inx 4228 14 an an DT cord-010092-uftc8inx 4228 15 integrated integrated JJ cord-010092-uftc8inx 4228 16 risk risk NN cord-010092-uftc8inx 4228 17 management management NN cord-010092-uftc8inx 4228 18 model model NN cord-010092-uftc8inx 4228 19 . . . cord-010092-uftc8inx 4229 1 Also also RB cord-010092-uftc8inx 4229 2 , , , cord-010092-uftc8inx 4229 3 it -PRON- PRP cord-010092-uftc8inx 4229 4 shows show VBZ cord-010092-uftc8inx 4229 5 the the DT cord-010092-uftc8inx 4229 6 main main JJ cord-010092-uftc8inx 4229 7 results result NNS cord-010092-uftc8inx 4229 8 obtained obtain VBN cord-010092-uftc8inx 4229 9 after after IN cord-010092-uftc8inx 4229 10 10 10 CD cord-010092-uftc8inx 4229 11 years year NNS cord-010092-uftc8inx 4229 12 of of IN cord-010092-uftc8inx 4229 13 data datum NNS cord-010092-uftc8inx 4229 14 monitoring monitoring NN cord-010092-uftc8inx 4229 15 and and CC cord-010092-uftc8inx 4229 16 coordination coordination NN cord-010092-uftc8inx 4229 17 of of IN cord-010092-uftc8inx 4229 18 regulatory regulatory JJ cord-010092-uftc8inx 4229 19 actions action NNS cord-010092-uftc8inx 4229 20 and and CC cord-010092-uftc8inx 4229 21 policies policy NNS cord-010092-uftc8inx 4229 22 by by IN cord-010092-uftc8inx 4229 23 Anvisa Anvisa NNP cord-010092-uftc8inx 4229 24 , , , cord-010092-uftc8inx 4229 25 targeting target VBG cord-010092-uftc8inx 4229 26 quality quality NN cord-010092-uftc8inx 4229 27 and and CC cord-010092-uftc8inx 4229 28 safety safety NN cord-010092-uftc8inx 4229 29 of of IN cord-010092-uftc8inx 4229 30 blood blood NN cord-010092-uftc8inx 4229 31 products product NNS cord-010092-uftc8inx 4229 32 . . . cord-010092-uftc8inx 4230 1 Methods method NNS cord-010092-uftc8inx 4230 2 : : : cord-010092-uftc8inx 4230 3 The the DT cord-010092-uftc8inx 4230 4 utilization utilization NN cord-010092-uftc8inx 4230 5 of of IN cord-010092-uftc8inx 4230 6 MARPSH MARPSH NNP cord-010092-uftc8inx 4230 7 follows follow VBZ cord-010092-uftc8inx 4230 8 a a DT cord-010092-uftc8inx 4230 9 network network NN cord-010092-uftc8inx 4230 10 risk risk NN cord-010092-uftc8inx 4230 11 management management NN cord-010092-uftc8inx 4230 12 model model NN cord-010092-uftc8inx 4230 13 since since IN cord-010092-uftc8inx 4230 14 the the DT cord-010092-uftc8inx 4230 15 inspections inspection NNS cord-010092-uftc8inx 4230 16 are be VBP cord-010092-uftc8inx 4230 17 carried carry VBN cord-010092-uftc8inx 4230 18 out out RP cord-010092-uftc8inx 4230 19 by by IN cord-010092-uftc8inx 4230 20 decentralized decentralized JJ cord-010092-uftc8inx 4230 21 organs organ NNS cord-010092-uftc8inx 4230 22 in in IN cord-010092-uftc8inx 4230 23 all all DT cord-010092-uftc8inx 4230 24 27 27 CD cord-010092-uftc8inx 4230 25 states state NNS cord-010092-uftc8inx 4230 26 and and CC cord-010092-uftc8inx 4230 27 some some DT cord-010092-uftc8inx 4230 28 municipalities municipality NNS cord-010092-uftc8inx 4230 29 . . . cord-010092-uftc8inx 4231 1 The the DT cord-010092-uftc8inx 4231 2 inspectors inspector NNS cord-010092-uftc8inx 4231 3 fulfill fulfill VBP cord-010092-uftc8inx 4231 4 a a DT cord-010092-uftc8inx 4231 5 standardized standardized JJ cord-010092-uftc8inx 4231 6 inspection inspection NN cord-010092-uftc8inx 4231 7 guide guide NN cord-010092-uftc8inx 4231 8 containing contain VBG cord-010092-uftc8inx 4231 9 the the DT cord-010092-uftc8inx 4231 10 regulatory regulatory JJ cord-010092-uftc8inx 4231 11 requirements requirement NNS cord-010092-uftc8inx 4231 12 , , , cord-010092-uftc8inx 4231 13 where where WRB cord-010092-uftc8inx 4231 14 each each DT cord-010092-uftc8inx 4231 15 item item NN cord-010092-uftc8inx 4231 16 is be VBZ cord-010092-uftc8inx 4231 17 associated associate VBN cord-010092-uftc8inx 4231 18 with with IN cord-010092-uftc8inx 4231 19 a a DT cord-010092-uftc8inx 4231 20 level level NN cord-010092-uftc8inx 4231 21 of of IN cord-010092-uftc8inx 4231 22 risk risk NN cord-010092-uftc8inx 4231 23 , , , cord-010092-uftc8inx 4231 24 varying vary VBG cord-010092-uftc8inx 4231 25 from from IN cord-010092-uftc8inx 4231 26 I -PRON- PRP cord-010092-uftc8inx 4231 27 to to IN cord-010092-uftc8inx 4231 28 III III NNP cord-010092-uftc8inx 4231 29 as as IN cord-010092-uftc8inx 4231 30 the the DT cord-010092-uftc8inx 4231 31 risk risk NN cord-010092-uftc8inx 4231 32 increases increase VBZ cord-010092-uftc8inx 4231 33 . . . cord-010092-uftc8inx 4232 1 At at IN cord-010092-uftc8inx 4232 2 the the DT cord-010092-uftc8inx 4232 3 end end NN cord-010092-uftc8inx 4232 4 of of IN cord-010092-uftc8inx 4232 5 the the DT cord-010092-uftc8inx 4232 6 inspection inspection NN cord-010092-uftc8inx 4232 7 , , , cord-010092-uftc8inx 4232 8 after after IN cord-010092-uftc8inx 4232 9 a a DT cord-010092-uftc8inx 4232 10 statistical statistical JJ cord-010092-uftc8inx 4232 11 calculation calculation NN cord-010092-uftc8inx 4232 12 , , , cord-010092-uftc8inx 4232 13 the the DT cord-010092-uftc8inx 4232 14 service service NN cord-010092-uftc8inx 4232 15 is be VBZ cord-010092-uftc8inx 4232 16 categorized categorize VBN cord-010092-uftc8inx 4232 17 . . . cord-010092-uftc8inx 4233 1 This this DT cord-010092-uftc8inx 4233 2 classification classification NN cord-010092-uftc8inx 4233 3 gives give VBZ cord-010092-uftc8inx 4233 4 an an DT cord-010092-uftc8inx 4233 5 estimate estimate NN cord-010092-uftc8inx 4233 6 of of IN cord-010092-uftc8inx 4233 7 its -PRON- PRP$ cord-010092-uftc8inx 4233 8 quality quality NN cord-010092-uftc8inx 4233 9 profile profile NN cord-010092-uftc8inx 4233 10 , , , cord-010092-uftc8inx 4233 11 guiding guide VBG cord-010092-uftc8inx 4233 12 the the DT cord-010092-uftc8inx 4233 13 adoption adoption NN cord-010092-uftc8inx 4233 14 of of IN cord-010092-uftc8inx 4233 15 suitable suitable JJ cord-010092-uftc8inx 4233 16 measures measure NNS cord-010092-uftc8inx 4233 17 for for IN cord-010092-uftc8inx 4233 18 risk risk NN cord-010092-uftc8inx 4233 19 management management NN cord-010092-uftc8inx 4233 20 by by IN cord-010092-uftc8inx 4233 21 local local JJ cord-010092-uftc8inx 4233 22 authorities authority NNS cord-010092-uftc8inx 4233 23 and and CC cord-010092-uftc8inx 4233 24 services service NNS cord-010092-uftc8inx 4233 25 . . . cord-010092-uftc8inx 4234 1 These these DT cord-010092-uftc8inx 4234 2 data datum NNS cord-010092-uftc8inx 4234 3 are be VBP cord-010092-uftc8inx 4234 4 send send JJ cord-010092-uftc8inx 4234 5 to to IN cord-010092-uftc8inx 4234 6 the the DT cord-010092-uftc8inx 4234 7 states state NNS cord-010092-uftc8inx 4234 8 ( ( -LRB- cord-010092-uftc8inx 4234 9 if if IN cord-010092-uftc8inx 4234 10 realized realize VBN cord-010092-uftc8inx 4234 11 by by IN cord-010092-uftc8inx 4234 12 municipalities municipality NNS cord-010092-uftc8inx 4234 13 ) ) -RRB- cord-010092-uftc8inx 4234 14 and and CC cord-010092-uftc8inx 4234 15 to to IN cord-010092-uftc8inx 4234 16 Anvisa Anvisa NNP cord-010092-uftc8inx 4234 17 that that WDT cord-010092-uftc8inx 4234 18 perform perform VBP cord-010092-uftc8inx 4234 19 consolidation consolidation NN cord-010092-uftc8inx 4234 20 in in IN cord-010092-uftc8inx 4234 21 a a DT cord-010092-uftc8inx 4234 22 national national JJ cord-010092-uftc8inx 4234 23 level level NN cord-010092-uftc8inx 4234 24 . . . cord-010092-uftc8inx 4235 1 Either either DT cord-010092-uftc8inx 4235 2 states state NNS cord-010092-uftc8inx 4235 3 or or CC cord-010092-uftc8inx 4235 4 Anvisa Anvisa NNP cord-010092-uftc8inx 4235 5 use use VB cord-010092-uftc8inx 4235 6 data datum NNS cord-010092-uftc8inx 4235 7 to to TO cord-010092-uftc8inx 4235 8 coordinate coordinate VB cord-010092-uftc8inx 4235 9 risk risk NN cord-010092-uftc8inx 4235 10 management management NN cord-010092-uftc8inx 4235 11 measures measure NNS cord-010092-uftc8inx 4235 12 in in IN cord-010092-uftc8inx 4235 13 a a DT cord-010092-uftc8inx 4235 14 broader broad JJR cord-010092-uftc8inx 4235 15 spectrum spectrum NN cord-010092-uftc8inx 4235 16 . . . cord-010092-uftc8inx 4236 1 Data datum NNS cord-010092-uftc8inx 4236 2 are be VBP cord-010092-uftc8inx 4236 3 continuously continuously RB cord-010092-uftc8inx 4236 4 monitored monitor VBN cord-010092-uftc8inx 4236 5 by by IN cord-010092-uftc8inx 4236 6 Anvisa Anvisa NNP cord-010092-uftc8inx 4236 7 as as IN cord-010092-uftc8inx 4236 8 part part NN cord-010092-uftc8inx 4236 9 of of IN cord-010092-uftc8inx 4236 10 its -PRON- PRP$ cord-010092-uftc8inx 4236 11 strategical strategical JJ cord-010092-uftc8inx 4236 12 panel panel NN cord-010092-uftc8inx 4236 13 of of IN cord-010092-uftc8inx 4236 14 indicators indicator NNS cord-010092-uftc8inx 4236 15 . . . cord-010092-uftc8inx 4237 1 Anvisa Anvisa NNP cord-010092-uftc8inx 4237 2 follows follow VBZ cord-010092-uftc8inx 4237 3 up up RP cord-010092-uftc8inx 4237 4 specially specially RB cord-010092-uftc8inx 4237 5 blood blood NN cord-010092-uftc8inx 4237 6 services service NNS cord-010092-uftc8inx 4237 7 in in IN cord-010092-uftc8inx 4237 8 High High NNP cord-010092-uftc8inx 4237 9 and and CC cord-010092-uftc8inx 4237 10 Medium Medium NNP cord-010092-uftc8inx 4237 11 - - HYPH cord-010092-uftc8inx 4237 12 High high JJ cord-010092-uftc8inx 4237 13 Risk risk NN cord-010092-uftc8inx 4237 14 with with IN cord-010092-uftc8inx 4237 15 the the DT cord-010092-uftc8inx 4237 16 aim aim NN cord-010092-uftc8inx 4237 17 of of IN cord-010092-uftc8inx 4237 18 helping help VBG cord-010092-uftc8inx 4237 19 or or CC cord-010092-uftc8inx 4237 20 complementing complement VBG cord-010092-uftc8inx 4237 21 local local JJ cord-010092-uftc8inx 4237 22 authorities authority NNS cord-010092-uftc8inx 4237 23 ' ' POS cord-010092-uftc8inx 4237 24 actions action NNS cord-010092-uftc8inx 4237 25 . . . cord-010092-uftc8inx 4238 1 Additionally additionally RB cord-010092-uftc8inx 4238 2 , , , cord-010092-uftc8inx 4238 3 Anvisa Anvisa NNP cord-010092-uftc8inx 4238 4 periodically periodically RB cord-010092-uftc8inx 4238 5 sends send VBZ cord-010092-uftc8inx 4238 6 this this DT cord-010092-uftc8inx 4238 7 information information NN cord-010092-uftc8inx 4238 8 to to IN cord-010092-uftc8inx 4238 9 the the DT cord-010092-uftc8inx 4238 10 Brazilian Brazilian NNP cord-010092-uftc8inx 4238 11 Ministry Ministry NNP cord-010092-uftc8inx 4238 12 of of IN cord-010092-uftc8inx 4238 13 Health Health NNP cord-010092-uftc8inx 4238 14 and and CC cord-010092-uftc8inx 4238 15 local local JJ cord-010092-uftc8inx 4238 16 governmental governmental JJ cord-010092-uftc8inx 4238 17 organs organ NNS cord-010092-uftc8inx 4238 18 from from IN cord-010092-uftc8inx 4238 19 Brazilian brazilian JJ cord-010092-uftc8inx 4238 20 National National NNP cord-010092-uftc8inx 4238 21 Blood Blood NNP cord-010092-uftc8inx 4238 22 System System NNP cord-010092-uftc8inx 4238 23 that that WDT cord-010092-uftc8inx 4238 24 also also RB cord-010092-uftc8inx 4238 25 support support VBP cord-010092-uftc8inx 4238 26 actions action NNS cord-010092-uftc8inx 4238 27 to to TO cord-010092-uftc8inx 4238 28 improve improve VB cord-010092-uftc8inx 4238 29 quality quality NN cord-010092-uftc8inx 4238 30 in in IN cord-010092-uftc8inx 4238 31 their -PRON- PRP$ cord-010092-uftc8inx 4238 32 blood blood NN cord-010092-uftc8inx 4238 33 services service NNS cord-010092-uftc8inx 4238 34 networks network NNS cord-010092-uftc8inx 4238 35 . . . cord-010092-uftc8inx 4239 1 Results result NNS cord-010092-uftc8inx 4239 2 : : : cord-010092-uftc8inx 4240 1 Since since IN cord-010092-uftc8inx 4240 2 2007 2007 CD cord-010092-uftc8inx 4240 3 , , , cord-010092-uftc8inx 4240 4 when when WRB cord-010092-uftc8inx 4240 5 the the DT cord-010092-uftc8inx 4240 6 assessment assessment NN cord-010092-uftc8inx 4240 7 covered cover VBD cord-010092-uftc8inx 4240 8 109 109 CD cord-010092-uftc8inx 4240 9 blood blood NN cord-010092-uftc8inx 4240 10 services service NNS cord-010092-uftc8inx 4240 11 , , , cord-010092-uftc8inx 4240 12 MARPSH MARPSH NNP cord-010092-uftc8inx 4240 13 reached reach VBD cord-010092-uftc8inx 4240 14 1218 1218 CD cord-010092-uftc8inx 4240 15 blood blood NN cord-010092-uftc8inx 4240 16 services service NNS cord-010092-uftc8inx 4240 17 in in IN cord-010092-uftc8inx 4240 18 2017 2017 CD cord-010092-uftc8inx 4241 1 ( ( -LRB- cord-010092-uftc8inx 4241 2 57 57 CD cord-010092-uftc8inx 4241 3 % % NN cord-010092-uftc8inx 4241 4 of of IN cord-010092-uftc8inx 4241 5 the the DT cord-010092-uftc8inx 4241 6 blood blood NN cord-010092-uftc8inx 4241 7 services service NNS cord-010092-uftc8inx 4241 8 registered register VBD cord-010092-uftc8inx 4241 9 ) ) -RRB- cord-010092-uftc8inx 4241 10 what what WP cord-010092-uftc8inx 4241 11 corresponded correspond VBD cord-010092-uftc8inx 4241 12 to to IN cord-010092-uftc8inx 4241 13 almost almost RB cord-010092-uftc8inx 4241 14 100 100 CD cord-010092-uftc8inx 4241 15 % % NN cord-010092-uftc8inx 4241 16 of of IN cord-010092-uftc8inx 4241 17 the the DT cord-010092-uftc8inx 4241 18 inspection inspection NN cord-010092-uftc8inx 4241 19 cover cover NN cord-010092-uftc8inx 4241 20 in in IN cord-010092-uftc8inx 4241 21 this this DT cord-010092-uftc8inx 4241 22 year year NN cord-010092-uftc8inx 4241 23 . . . cord-010092-uftc8inx 4242 1 Over over IN cord-010092-uftc8inx 4242 2 this this DT cord-010092-uftc8inx 4242 3 period period NN cord-010092-uftc8inx 4242 4 ( ( -LRB- cord-010092-uftc8inx 4242 5 2007 2007 CD cord-010092-uftc8inx 4242 6 ) ) -RRB- cord-010092-uftc8inx 4242 7 ( ( -LRB- cord-010092-uftc8inx 4242 8 2008 2008 CD cord-010092-uftc8inx 4242 9 ) ) -RRB- cord-010092-uftc8inx 4242 10 ( ( -LRB- cord-010092-uftc8inx 4242 11 2009 2009 CD cord-010092-uftc8inx 4242 12 ) ) -RRB- cord-010092-uftc8inx 4242 13 ( ( -LRB- cord-010092-uftc8inx 4242 14 2010 2010 CD cord-010092-uftc8inx 4242 15 ) ) -RRB- cord-010092-uftc8inx 4242 16 ( ( -LRB- cord-010092-uftc8inx 4242 17 2011 2011 CD cord-010092-uftc8inx 4242 18 ) ) -RRB- cord-010092-uftc8inx 4242 19 ( ( -LRB- cord-010092-uftc8inx 4242 20 2012 2012 CD cord-010092-uftc8inx 4242 21 ) ) -RRB- cord-010092-uftc8inx 4242 22 ( ( -LRB- cord-010092-uftc8inx 4242 23 2013 2013 CD cord-010092-uftc8inx 4242 24 ) ) -RRB- cord-010092-uftc8inx 4242 25 ( ( -LRB- cord-010092-uftc8inx 4242 26 2014 2014 CD cord-010092-uftc8inx 4242 27 ) ) -RRB- cord-010092-uftc8inx 4242 28 ( ( -LRB- cord-010092-uftc8inx 4242 29 2015 2015 CD cord-010092-uftc8inx 4242 30 ) ) -RRB- cord-010092-uftc8inx 4242 31 ( ( -LRB- cord-010092-uftc8inx 4242 32 2016 2016 CD cord-010092-uftc8inx 4242 33 ) ) -RRB- cord-010092-uftc8inx 4242 34 ( ( -LRB- cord-010092-uftc8inx 4242 35 2017 2017 CD cord-010092-uftc8inx 4242 36 ) ) -RRB- cord-010092-uftc8inx 4242 37 it -PRON- PRP cord-010092-uftc8inx 4242 38 is be VBZ cord-010092-uftc8inx 4242 39 possible possible JJ cord-010092-uftc8inx 4242 40 to to TO cord-010092-uftc8inx 4242 41 notice notice VB cord-010092-uftc8inx 4242 42 a a DT cord-010092-uftc8inx 4242 43 dramatic dramatic JJ cord-010092-uftc8inx 4242 44 decreasing decreasing NN cord-010092-uftc8inx 4242 45 in in IN cord-010092-uftc8inx 4242 46 trend trend NN cord-010092-uftc8inx 4242 47 for for IN cord-010092-uftc8inx 4242 48 proportion proportion NN cord-010092-uftc8inx 4242 49 of of IN cord-010092-uftc8inx 4242 50 blood blood NN cord-010092-uftc8inx 4242 51 services service NNS cord-010092-uftc8inx 4242 52 classified classify VBN cord-010092-uftc8inx 4242 53 as as IN cord-010092-uftc8inx 4242 54 High High NNP cord-010092-uftc8inx 4242 55 and and CC cord-010092-uftc8inx 4242 56 Medium Medium NNP cord-010092-uftc8inx 4242 57 - - HYPH cord-010092-uftc8inx 4242 58 High high JJ cord-010092-uftc8inx 4242 59 Risk risk NN cord-010092-uftc8inx 4242 60 , , , cord-010092-uftc8inx 4242 61 varying vary VBG cord-010092-uftc8inx 4242 62 from from IN cord-010092-uftc8inx 4242 63 26 26 CD cord-010092-uftc8inx 4242 64 % % NN cord-010092-uftc8inx 4242 65 to to TO cord-010092-uftc8inx 4242 66 9 9 CD cord-010092-uftc8inx 4242 67 % % NN cord-010092-uftc8inx 4242 68 . . . cord-010092-uftc8inx 4243 1 Summary Summary NNP cord-010092-uftc8inx 4243 2 / / SYM cord-010092-uftc8inx 4243 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 4243 4 : : : cord-010092-uftc8inx 4244 1 MARPSH MARPSH NNP cord-010092-uftc8inx 4244 2 generates generate VBZ cord-010092-uftc8inx 4244 3 data datum NNS cord-010092-uftc8inx 4244 4 necessary necessary JJ cord-010092-uftc8inx 4244 5 to to IN cord-010092-uftc8inx 4244 6 the the DT cord-010092-uftc8inx 4244 7 categorization categorization NN cord-010092-uftc8inx 4244 8 of of IN cord-010092-uftc8inx 4244 9 blood blood NN cord-010092-uftc8inx 4244 10 services service NNS cord-010092-uftc8inx 4244 11 into into IN cord-010092-uftc8inx 4244 12 five five CD cord-010092-uftc8inx 4244 13 levels level NNS cord-010092-uftc8inx 4244 14 of of IN cord-010092-uftc8inx 4244 15 potential potential JJ cord-010092-uftc8inx 4244 16 risk risk NN cord-010092-uftc8inx 4244 17 . . . cord-010092-uftc8inx 4245 1 As as IN cord-010092-uftc8inx 4245 2 a a DT cord-010092-uftc8inx 4245 3 result result NN cord-010092-uftc8inx 4245 4 , , , cord-010092-uftc8inx 4245 5 the the DT cord-010092-uftc8inx 4245 6 regulatory regulatory JJ cord-010092-uftc8inx 4245 7 actions action NNS cord-010092-uftc8inx 4245 8 are be VBP cord-010092-uftc8inx 4245 9 applied apply VBN cord-010092-uftc8inx 4245 10 by by IN cord-010092-uftc8inx 4245 11 local local JJ cord-010092-uftc8inx 4245 12 organs organ NNS cord-010092-uftc8inx 4245 13 with with IN cord-010092-uftc8inx 4245 14 the the DT cord-010092-uftc8inx 4245 15 purpose purpose NN cord-010092-uftc8inx 4245 16 of of IN cord-010092-uftc8inx 4245 17 reducing reduce VBG cord-010092-uftc8inx 4245 18 or or CC cord-010092-uftc8inx 4245 19 eliminating eliminate VBG cord-010092-uftc8inx 4245 20 risks risk NNS cord-010092-uftc8inx 4245 21 involved involve VBN cord-010092-uftc8inx 4245 22 in in IN cord-010092-uftc8inx 4245 23 the the DT cord-010092-uftc8inx 4245 24 production production NN cord-010092-uftc8inx 4245 25 and and CC cord-010092-uftc8inx 4245 26 use use NN cord-010092-uftc8inx 4245 27 of of IN cord-010092-uftc8inx 4245 28 blood blood NN cord-010092-uftc8inx 4245 29 components component NNS cord-010092-uftc8inx 4245 30 . . . cord-010092-uftc8inx 4246 1 Data datum NNS cord-010092-uftc8inx 4246 2 have have VBP cord-010092-uftc8inx 4246 3 shown show VBN cord-010092-uftc8inx 4246 4 a a DT cord-010092-uftc8inx 4246 5 significant significant JJ cord-010092-uftc8inx 4246 6 risk risk NN cord-010092-uftc8inx 4246 7 reduction reduction NN cord-010092-uftc8inx 4246 8 over over IN cord-010092-uftc8inx 4246 9 10 10 CD cord-010092-uftc8inx 4246 10 years year NNS cord-010092-uftc8inx 4246 11 of of IN cord-010092-uftc8inx 4246 12 MARPSH MARPSH NNP cord-010092-uftc8inx 4246 13 's 's POS cord-010092-uftc8inx 4246 14 utilization utilization NN cord-010092-uftc8inx 4246 15 . . . cord-010092-uftc8inx 4247 1 Additionally additionally RB cord-010092-uftc8inx 4247 2 , , , cord-010092-uftc8inx 4247 3 monitoring monitoring NN cord-010092-uftc8inx 4247 4 of of IN cord-010092-uftc8inx 4247 5 this this DT cord-010092-uftc8inx 4247 6 data datum NNS cord-010092-uftc8inx 4247 7 at at IN cord-010092-uftc8inx 4247 8 a a DT cord-010092-uftc8inx 4247 9 national national JJ cord-010092-uftc8inx 4247 10 level level NN cord-010092-uftc8inx 4247 11 has have VBZ cord-010092-uftc8inx 4247 12 been be VBN cord-010092-uftc8inx 4247 13 permitting permit VBG cord-010092-uftc8inx 4247 14 appropriate appropriate JJ cord-010092-uftc8inx 4247 15 planning planning NN cord-010092-uftc8inx 4247 16 and and CC cord-010092-uftc8inx 4247 17 prioritization prioritization NN cord-010092-uftc8inx 4247 18 of of IN cord-010092-uftc8inx 4247 19 integrated integrate VBN cord-010092-uftc8inx 4247 20 strategies strategy NNS cord-010092-uftc8inx 4247 21 directed direct VBN cord-010092-uftc8inx 4247 22 to to IN cord-010092-uftc8inx 4247 23 risk risk VB cord-010092-uftc8inx 4247 24 management management NN cord-010092-uftc8inx 4247 25 and and CC cord-010092-uftc8inx 4247 26 strengthening strengthening NN cord-010092-uftc8inx 4247 27 of of IN cord-010092-uftc8inx 4247 28 blood blood NN cord-010092-uftc8inx 4247 29 services service NNS cord-010092-uftc8inx 4247 30 in in IN cord-010092-uftc8inx 4247 31 Brazil Brazil NNP cord-010092-uftc8inx 4247 32 . . . cord-010092-uftc8inx 4248 1 Background background NN cord-010092-uftc8inx 4248 2 : : : cord-010092-uftc8inx 4249 1 Sub sub JJ cord-010092-uftc8inx 4249 2 - - HYPH cord-010092-uftc8inx 4249 3 Saharan Saharan NNP cord-010092-uftc8inx 4249 4 Africa Africa NNP cord-010092-uftc8inx 4249 5 has have VBZ cord-010092-uftc8inx 4249 6 the the DT cord-010092-uftc8inx 4249 7 highest high JJS cord-010092-uftc8inx 4249 8 need need NN cord-010092-uftc8inx 4249 9 of of IN cord-010092-uftc8inx 4249 10 blood blood NN cord-010092-uftc8inx 4249 11 transfusion transfusion NN cord-010092-uftc8inx 4249 12 in in IN cord-010092-uftc8inx 4249 13 the the DT cord-010092-uftc8inx 4249 14 world world NN cord-010092-uftc8inx 4249 15 , , , cord-010092-uftc8inx 4249 16 mainly mainly RB cord-010092-uftc8inx 4249 17 for for IN cord-010092-uftc8inx 4249 18 childbearing childbeare VBG cord-010092-uftc8inx 4249 19 women woman NNS cord-010092-uftc8inx 4249 20 and and CC cord-010092-uftc8inx 4249 21 children child NNS cord-010092-uftc8inx 4249 22 suffering suffer VBG cord-010092-uftc8inx 4249 23 from from IN cord-010092-uftc8inx 4249 24 malaria malaria NN cord-010092-uftc8inx 4249 25 . . . cord-010092-uftc8inx 4250 1 Meeting meet VBG cord-010092-uftc8inx 4250 2 basic basic JJ cord-010092-uftc8inx 4250 3 quality quality NN cord-010092-uftc8inx 4250 4 and and CC cord-010092-uftc8inx 4250 5 operational operational JJ cord-010092-uftc8inx 4250 6 requirements requirement NNS cord-010092-uftc8inx 4250 7 to to TO cord-010092-uftc8inx 4250 8 provide provide VB cord-010092-uftc8inx 4250 9 patients patient NNS cord-010092-uftc8inx 4250 10 with with IN cord-010092-uftc8inx 4250 11 safe safe JJ cord-010092-uftc8inx 4250 12 blood blood NN cord-010092-uftc8inx 4250 13 remains remain VBZ cord-010092-uftc8inx 4250 14 a a DT cord-010092-uftc8inx 4250 15 challenge challenge NN cord-010092-uftc8inx 4250 16 in in IN cord-010092-uftc8inx 4250 17 these these DT cord-010092-uftc8inx 4250 18 settings setting NNS cord-010092-uftc8inx 4250 19 . . . cord-010092-uftc8inx 4251 1 Aims aim VBZ cord-010092-uftc8inx 4251 2 : : : cord-010092-uftc8inx 4252 1 The the DT cord-010092-uftc8inx 4252 2 aim aim NN cord-010092-uftc8inx 4252 3 was be VBD cord-010092-uftc8inx 4252 4 to to TO cord-010092-uftc8inx 4252 5 identify identify VB cord-010092-uftc8inx 4252 6 and and CC cord-010092-uftc8inx 4252 7 prioritize prioritize VB cord-010092-uftc8inx 4252 8 potential potential JJ cord-010092-uftc8inx 4252 9 hazards hazard NNS cord-010092-uftc8inx 4252 10 for for IN cord-010092-uftc8inx 4252 11 patients patient NNS cord-010092-uftc8inx 4252 12 in in IN cord-010092-uftc8inx 4252 13 blood blood NN cord-010092-uftc8inx 4252 14 bank bank NN cord-010092-uftc8inx 4252 15 practices practice NNS cord-010092-uftc8inx 4252 16 in in IN cord-010092-uftc8inx 4252 17 the the DT cord-010092-uftc8inx 4252 18 Democratic Democratic NNP cord-010092-uftc8inx 4252 19 Republic Republic NNP cord-010092-uftc8inx 4252 20 of of IN cord-010092-uftc8inx 4252 21 the the DT cord-010092-uftc8inx 4252 22 Congo Congo NNP cord-010092-uftc8inx 4252 23 ( ( -LRB- cord-010092-uftc8inx 4252 24 DRC DRC NNP cord-010092-uftc8inx 4252 25 ) ) -RRB- cord-010092-uftc8inx 4252 26 . . . cord-010092-uftc8inx 4253 1 We -PRON- PRP cord-010092-uftc8inx 4253 2 focused focus VBD cord-010092-uftc8inx 4253 3 on on IN cord-010092-uftc8inx 4253 4 two two CD cord-010092-uftc8inx 4253 5 subsets subset NNS cord-010092-uftc8inx 4253 6 : : : cord-010092-uftc8inx 4253 7 ( ( -LRB- cord-010092-uftc8inx 4253 8 i i NN cord-010092-uftc8inx 4253 9 ) ) -RRB- cord-010092-uftc8inx 4253 10 sensibilisation sensibilisation NN cord-010092-uftc8inx 4253 11 and and CC cord-010092-uftc8inx 4253 12 selection selection NN cord-010092-uftc8inx 4253 13 of of IN cord-010092-uftc8inx 4253 14 donors donor NNS cord-010092-uftc8inx 4253 15 , , , cord-010092-uftc8inx 4253 16 and and CC cord-010092-uftc8inx 4253 17 ( ( -LRB- cord-010092-uftc8inx 4253 18 ii ii NN cord-010092-uftc8inx 4253 19 ) ) -RRB- cord-010092-uftc8inx 4253 20 qualification qualification NN cord-010092-uftc8inx 4253 21 and and CC cord-010092-uftc8inx 4253 22 production production NN cord-010092-uftc8inx 4253 23 of of IN cord-010092-uftc8inx 4253 24 blood blood NN cord-010092-uftc8inx 4253 25 products product NNS cord-010092-uftc8inx 4253 26 , , , cord-010092-uftc8inx 4253 27 using use VBG cord-010092-uftc8inx 4253 28 Failure failure NN cord-010092-uftc8inx 4253 29 Mode Mode NNP cord-010092-uftc8inx 4253 30 Effect Effect NNP cord-010092-uftc8inx 4253 31 Analysis Analysis NNP cord-010092-uftc8inx 4253 32 ( ( -LRB- cord-010092-uftc8inx 4253 33 FMEA FMEA NNP cord-010092-uftc8inx 4253 34 ) ) -RRB- cord-010092-uftc8inx 4253 35 . . . cord-010092-uftc8inx 4254 1 Methods method NNS cord-010092-uftc8inx 4254 2 : : : cord-010092-uftc8inx 4255 1 Two two CD cord-010092-uftc8inx 4255 2 risk risk NN cord-010092-uftc8inx 4255 3 analysis analysis NN cord-010092-uftc8inx 4255 4 workshops workshop NNS cord-010092-uftc8inx 4255 5 were be VBD cord-010092-uftc8inx 4255 6 organized organize VBN cord-010092-uftc8inx 4255 7 at at IN cord-010092-uftc8inx 4255 8 the the DT cord-010092-uftc8inx 4255 9 National National NNP cord-010092-uftc8inx 4255 10 Blood Blood NNP cord-010092-uftc8inx 4255 11 Transfusion Transfusion NNP cord-010092-uftc8inx 4255 12 Centre Centre NNP cord-010092-uftc8inx 4255 13 in in IN cord-010092-uftc8inx 4255 14 Kinshasa Kinshasa NNP cord-010092-uftc8inx 4255 15 , , , cord-010092-uftc8inx 4255 16 the the DT cord-010092-uftc8inx 4255 17 Democratic Democratic NNP cord-010092-uftc8inx 4255 18 Republic Republic NNP cord-010092-uftc8inx 4255 19 of of IN cord-010092-uftc8inx 4255 20 the the DT cord-010092-uftc8inx 4255 21 Congo Congo NNP cord-010092-uftc8inx 4255 22 . . . cord-010092-uftc8inx 4256 1 In in IN cord-010092-uftc8inx 4256 2 both both DT cord-010092-uftc8inx 4256 3 workshops workshop NNS cord-010092-uftc8inx 4256 4 , , , cord-010092-uftc8inx 4256 5 a a DT cord-010092-uftc8inx 4256 6 multidisciplinary multidisciplinary JJ cord-010092-uftc8inx 4256 7 team team NN cord-010092-uftc8inx 4256 8 was be VBD cord-010092-uftc8inx 4256 9 invited invite VBN cord-010092-uftc8inx 4256 10 to to TO cord-010092-uftc8inx 4256 11 represent represent VB cord-010092-uftc8inx 4256 12 different different JJ cord-010092-uftc8inx 4256 13 hospitals hospital NNS cord-010092-uftc8inx 4256 14 and and CC cord-010092-uftc8inx 4256 15 profiles profile NNS cord-010092-uftc8inx 4256 16 in in IN cord-010092-uftc8inx 4256 17 transfusion transfusion NN cord-010092-uftc8inx 4256 18 management management NN cord-010092-uftc8inx 4256 19 in in IN cord-010092-uftc8inx 4256 20 DRC DRC NNP cord-010092-uftc8inx 4256 21 : : : cord-010092-uftc8inx 4256 22 quality quality NN cord-010092-uftc8inx 4256 23 coordinators coordinator NNS cord-010092-uftc8inx 4256 24 ( ( -LRB- cord-010092-uftc8inx 4256 25 n n NN cord-010092-uftc8inx 4256 26 = = SYM cord-010092-uftc8inx 4256 27 2 2 CD cord-010092-uftc8inx 4256 28 ) ) -RRB- cord-010092-uftc8inx 4256 29 , , , cord-010092-uftc8inx 4256 30 training training NN cord-010092-uftc8inx 4256 31 coordinator coordinator NN cord-010092-uftc8inx 4256 32 ( ( -LRB- cord-010092-uftc8inx 4256 33 n n NN cord-010092-uftc8inx 4256 34 = = SYM cord-010092-uftc8inx 4256 35 1 1 CD cord-010092-uftc8inx 4256 36 ) ) -RRB- cord-010092-uftc8inx 4256 37 , , , cord-010092-uftc8inx 4256 38 medical medical JJ cord-010092-uftc8inx 4256 39 doctor doctor NN cord-010092-uftc8inx 4256 40 for for IN cord-010092-uftc8inx 4256 41 donor donor NN cord-010092-uftc8inx 4256 42 selection selection NN cord-010092-uftc8inx 4256 43 ( ( -LRB- cord-010092-uftc8inx 4256 44 n n NN cord-010092-uftc8inx 4256 45 = = SYM cord-010092-uftc8inx 4256 46 2 2 CD cord-010092-uftc8inx 4256 47 ) ) -RRB- cord-010092-uftc8inx 4256 48 , , , cord-010092-uftc8inx 4256 49 hemovigilance hemovigilance NN cord-010092-uftc8inx 4256 50 officer officer NN cord-010092-uftc8inx 4256 51 ( ( -LRB- cord-010092-uftc8inx 4256 52 n n NN cord-010092-uftc8inx 4256 53 = = SYM cord-010092-uftc8inx 4256 54 1 1 CD cord-010092-uftc8inx 4256 55 ) ) -RRB- cord-010092-uftc8inx 4256 56 , , , cord-010092-uftc8inx 4256 57 laboratory laboratory NN cord-010092-uftc8inx 4256 58 technicians technician NNS cord-010092-uftc8inx 4256 59 performing perform VBG cord-010092-uftc8inx 4256 60 donor donor NN cord-010092-uftc8inx 4256 61 sampling sampling NN cord-010092-uftc8inx 4256 62 , , , cord-010092-uftc8inx 4256 63 blood blood NN cord-010092-uftc8inx 4256 64 qualification qualification NN cord-010092-uftc8inx 4256 65 and and CC cord-010092-uftc8inx 4256 66 production production NN cord-010092-uftc8inx 4256 67 ( ( -LRB- cord-010092-uftc8inx 4256 68 n n NN cord-010092-uftc8inx 4256 69 = = SYM cord-010092-uftc8inx 4256 70 7 7 CD cord-010092-uftc8inx 4256 71 ) ) -RRB- cord-010092-uftc8inx 4256 72 , , , cord-010092-uftc8inx 4256 73 biomedical biomedical JJ cord-010092-uftc8inx 4256 74 scientists scientist NNS cord-010092-uftc8inx 4256 75 ( ( -LRB- cord-010092-uftc8inx 4256 76 n n NN cord-010092-uftc8inx 4256 77 = = SYM cord-010092-uftc8inx 4256 78 3 3 CD cord-010092-uftc8inx 4256 79 ) ) -RRB- cord-010092-uftc8inx 4256 80 , , , cord-010092-uftc8inx 4256 81 microbiologist microbiologist NN cord-010092-uftc8inx 4256 82 ( ( -LRB- cord-010092-uftc8inx 4256 83 n n NN cord-010092-uftc8inx 4256 84 = = SYM cord-010092-uftc8inx 4256 85 1 1 CD cord-010092-uftc8inx 4256 86 ) ) -RRB- cord-010092-uftc8inx 4256 87 , , , cord-010092-uftc8inx 4256 88 clinical clinical JJ cord-010092-uftc8inx 4256 89 biologist biologist NN cord-010092-uftc8inx 4256 90 ( ( -LRB- cord-010092-uftc8inx 4256 91 n n NN cord-010092-uftc8inx 4256 92 = = SYM cord-010092-uftc8inx 4256 93 1 1 CD cord-010092-uftc8inx 4256 94 ) ) -RRB- cord-010092-uftc8inx 4256 95 , , , cord-010092-uftc8inx 4256 96 nurse nurse NN cord-010092-uftc8inx 4256 97 ( ( -LRB- cord-010092-uftc8inx 4256 98 n n NN cord-010092-uftc8inx 4256 99 = = SYM cord-010092-uftc8inx 4256 100 3 3 CD cord-010092-uftc8inx 4256 101 ) ) -RRB- cord-010092-uftc8inx 4256 102 . . . cord-010092-uftc8inx 4257 1 The the DT cord-010092-uftc8inx 4257 2 principle principle NN cord-010092-uftc8inx 4257 3 of of IN cord-010092-uftc8inx 4257 4 FMEA FMEA NNP cord-010092-uftc8inx 4257 5 was be VBD cord-010092-uftc8inx 4257 6 applied apply VBN cord-010092-uftc8inx 4257 7 , , , cord-010092-uftc8inx 4257 8 which which WDT cord-010092-uftc8inx 4257 9 implies imply VBZ cord-010092-uftc8inx 4257 10 identification identification NN cord-010092-uftc8inx 4257 11 of of IN cord-010092-uftc8inx 4257 12 possible possible JJ cord-010092-uftc8inx 4257 13 hazards hazard NNS cord-010092-uftc8inx 4257 14 ( ( -LRB- cord-010092-uftc8inx 4257 15 failures failure NNS cord-010092-uftc8inx 4257 16 ) ) -RRB- cord-010092-uftc8inx 4257 17 in in IN cord-010092-uftc8inx 4257 18 a a DT cord-010092-uftc8inx 4257 19 process process NN cord-010092-uftc8inx 4257 20 flow flow NN cord-010092-uftc8inx 4257 21 , , , cord-010092-uftc8inx 4257 22 followed follow VBN cord-010092-uftc8inx 4257 23 by by IN cord-010092-uftc8inx 4257 24 scoring score VBG cord-010092-uftc8inx 4257 25 each each DT cord-010092-uftc8inx 4257 26 hazard hazard NN cord-010092-uftc8inx 4257 27 according accord VBG cord-010092-uftc8inx 4257 28 to to IN cord-010092-uftc8inx 4257 29 their -PRON- PRP$ cord-010092-uftc8inx 4257 30 impact impact NN cord-010092-uftc8inx 4257 31 , , , cord-010092-uftc8inx 4257 32 probability probability NN cord-010092-uftc8inx 4257 33 , , , cord-010092-uftc8inx 4257 34 detection detection NN cord-010092-uftc8inx 4257 35 and and CC cord-010092-uftc8inx 4257 36 feasibility feasibility NN cord-010092-uftc8inx 4257 37 . . . cord-010092-uftc8inx 4258 1 In in IN cord-010092-uftc8inx 4258 2 the the DT cord-010092-uftc8inx 4258 3 both both DT cord-010092-uftc8inx 4258 4 workshops workshop NNS cord-010092-uftc8inx 4258 5 , , , cord-010092-uftc8inx 4258 6 participants participant NNS cord-010092-uftc8inx 4258 7 were be VBD cord-010092-uftc8inx 4258 8 guided guide VBN cord-010092-uftc8inx 4258 9 by by IN cord-010092-uftc8inx 4258 10 an an DT cord-010092-uftc8inx 4258 11 external external JJ cord-010092-uftc8inx 4258 12 facilitator facilitator NN cord-010092-uftc8inx 4258 13 who who WP cord-010092-uftc8inx 4258 14 guaranteed guarantee VBD cord-010092-uftc8inx 4258 15 common common JJ cord-010092-uftc8inx 4258 16 understanding understanding NN cord-010092-uftc8inx 4258 17 of of IN cord-010092-uftc8inx 4258 18 the the DT cord-010092-uftc8inx 4258 19 methodology methodology NN cord-010092-uftc8inx 4258 20 . . . cord-010092-uftc8inx 4259 1 Main main JJ cord-010092-uftc8inx 4259 2 focus focus NN cord-010092-uftc8inx 4259 3 of of IN cord-010092-uftc8inx 4259 4 the the DT cord-010092-uftc8inx 4259 5 risk risk NN cord-010092-uftc8inx 4259 6 analysis analysis NN cord-010092-uftc8inx 4259 7 was be VBD cord-010092-uftc8inx 4259 8 potential potential JJ cord-010092-uftc8inx 4259 9 harm harm NN cord-010092-uftc8inx 4259 10 to to IN cord-010092-uftc8inx 4259 11 the the DT cord-010092-uftc8inx 4259 12 transfused transfuse VBN cord-010092-uftc8inx 4259 13 patient patient NN cord-010092-uftc8inx 4259 14 in in IN cord-010092-uftc8inx 4259 15 the the DT cord-010092-uftc8inx 4259 16 process process NN cord-010092-uftc8inx 4259 17 of of IN cord-010092-uftc8inx 4259 18 ( ( -LRB- cord-010092-uftc8inx 4259 19 i i NN cord-010092-uftc8inx 4259 20 ) ) -RRB- cord-010092-uftc8inx 4259 21 sensibilisation sensibilisation NN cord-010092-uftc8inx 4259 22 and and CC cord-010092-uftc8inx 4259 23 selection selection NN cord-010092-uftc8inx 4259 24 of of IN cord-010092-uftc8inx 4259 25 donors donor NNS cord-010092-uftc8inx 4259 26 , , , cord-010092-uftc8inx 4259 27 and and CC cord-010092-uftc8inx 4259 28 ( ( -LRB- cord-010092-uftc8inx 4259 29 ii ii NN cord-010092-uftc8inx 4259 30 ) ) -RRB- cord-010092-uftc8inx 4259 31 qualification qualification NN cord-010092-uftc8inx 4259 32 and and CC cord-010092-uftc8inx 4259 33 production production NN cord-010092-uftc8inx 4259 34 of of IN cord-010092-uftc8inx 4259 35 blood blood NN cord-010092-uftc8inx 4259 36 products product NNS cord-010092-uftc8inx 4259 37 . . . cord-010092-uftc8inx 4260 1 All all DT cord-010092-uftc8inx 4260 2 ideas idea NNS cord-010092-uftc8inx 4260 3 were be VBD cord-010092-uftc8inx 4260 4 written write VBN cord-010092-uftc8inx 4260 5 on on IN cord-010092-uftc8inx 4260 6 coloured coloured JJ cord-010092-uftc8inx 4260 7 cards card NNS cord-010092-uftc8inx 4260 8 and and CC cord-010092-uftc8inx 4260 9 mapped map VBN cord-010092-uftc8inx 4260 10 on on IN cord-010092-uftc8inx 4260 11 a a DT cord-010092-uftc8inx 4260 12 chart chart NN cord-010092-uftc8inx 4260 13 according accord VBG cord-010092-uftc8inx 4260 14 to to IN cord-010092-uftc8inx 4260 15 their -PRON- PRP$ cord-010092-uftc8inx 4260 16 impact impact NN cord-010092-uftc8inx 4260 17 , , , cord-010092-uftc8inx 4260 18 probability probability NN cord-010092-uftc8inx 4260 19 , , , cord-010092-uftc8inx 4260 20 detection detection NN cord-010092-uftc8inx 4260 21 and and CC cord-010092-uftc8inx 4260 22 feasibility feasibility NN cord-010092-uftc8inx 4260 23 score score NN cord-010092-uftc8inx 4260 24 . . . cord-010092-uftc8inx 4261 1 Hazards hazard NNS cord-010092-uftc8inx 4261 2 were be VBD cord-010092-uftc8inx 4261 3 ranked rank VBN cord-010092-uftc8inx 4261 4 according accord VBG cord-010092-uftc8inx 4261 5 to to IN cord-010092-uftc8inx 4261 6 their -PRON- PRP$ cord-010092-uftc8inx 4261 7 final final JJ cord-010092-uftc8inx 4261 8 risk risk NN cord-010092-uftc8inx 4261 9 score score NN cord-010092-uftc8inx 4261 10 by by IN cord-010092-uftc8inx 4261 11 multiplying multiply VBG cord-010092-uftc8inx 4261 12 these these DT cord-010092-uftc8inx 4261 13 four four CD cord-010092-uftc8inx 4261 14 scores score NNS cord-010092-uftc8inx 4261 15 . . . cord-010092-uftc8inx 4262 1 Results result NNS cord-010092-uftc8inx 4262 2 : : : cord-010092-uftc8inx 4263 1 In in IN cord-010092-uftc8inx 4263 2 the the DT cord-010092-uftc8inx 4263 3 process process NN cord-010092-uftc8inx 4263 4 of of IN cord-010092-uftc8inx 4263 5 sensibilisation sensibilisation NN cord-010092-uftc8inx 4263 6 and and CC cord-010092-uftc8inx 4263 7 selection selection NN cord-010092-uftc8inx 4263 8 of of IN cord-010092-uftc8inx 4263 9 donors donor NNS cord-010092-uftc8inx 4263 10 , , , cord-010092-uftc8inx 4263 11 the the DT cord-010092-uftc8inx 4263 12 three three CD cord-010092-uftc8inx 4263 13 hazards hazard NNS cord-010092-uftc8inx 4263 14 with with IN cord-010092-uftc8inx 4263 15 the the DT cord-010092-uftc8inx 4263 16 highest high JJS cord-010092-uftc8inx 4263 17 final final JJ cord-010092-uftc8inx 4263 18 score score NN cord-010092-uftc8inx 4263 19 for for IN cord-010092-uftc8inx 4263 20 impact impact NN cord-010092-uftc8inx 4263 21 , , , cord-010092-uftc8inx 4263 22 probability probability NN cord-010092-uftc8inx 4263 23 , , , cord-010092-uftc8inx 4263 24 detection detection NN cord-010092-uftc8inx 4263 25 and and CC cord-010092-uftc8inx 4263 26 feasibility feasibility NN cord-010092-uftc8inx 4263 27 were be VBD cord-010092-uftc8inx 4263 28 : : : cord-010092-uftc8inx 4263 29 ( ( -LRB- cord-010092-uftc8inx 4264 1 i i PRP cord-010092-uftc8inx 4264 2 ) ) -RRB- cord-010092-uftc8inx 4264 3 a a DT cord-010092-uftc8inx 4264 4 paid pay VBN cord-010092-uftc8inx 4264 5 donor donor NN cord-010092-uftc8inx 4264 6 is be VBZ cord-010092-uftc8inx 4264 7 recruited recruit VBN cord-010092-uftc8inx 4264 8 after after IN cord-010092-uftc8inx 4264 9 sensibilisation sensibilisation NN cord-010092-uftc8inx 4264 10 by by IN cord-010092-uftc8inx 4264 11 family family NN cord-010092-uftc8inx 4264 12 members member NNS cord-010092-uftc8inx 4264 13 of of IN cord-010092-uftc8inx 4264 14 the the DT cord-010092-uftc8inx 4264 15 patient patient NN cord-010092-uftc8inx 4264 16 , , , cord-010092-uftc8inx 4264 17 ( ( -LRB- cord-010092-uftc8inx 4264 18 ii ii NN cord-010092-uftc8inx 4264 19 ) ) -RRB- cord-010092-uftc8inx 4264 20 donor donor NN cord-010092-uftc8inx 4264 21 selection selection NN cord-010092-uftc8inx 4264 22 staff staff NN cord-010092-uftc8inx 4264 23 approves approve VBZ cord-010092-uftc8inx 4264 24 a a DT cord-010092-uftc8inx 4264 25 non non JJ cord-010092-uftc8inx 4264 26 - - JJ cord-010092-uftc8inx 4264 27 eligible eligible JJ cord-010092-uftc8inx 4264 28 donor donor NN cord-010092-uftc8inx 4264 29 for for IN cord-010092-uftc8inx 4264 30 blood blood NN cord-010092-uftc8inx 4264 31 donation donation NN cord-010092-uftc8inx 4264 32 because because IN cord-010092-uftc8inx 4264 33 of of IN cord-010092-uftc8inx 4264 34 personal personal JJ cord-010092-uftc8inx 4264 35 / / SYM cord-010092-uftc8inx 4264 36 financial financial JJ cord-010092-uftc8inx 4264 37 motivation motivation NN cord-010092-uftc8inx 4264 38 , , , cord-010092-uftc8inx 4264 39 ( ( -LRB- cord-010092-uftc8inx 4264 40 iii iii NN cord-010092-uftc8inx 4264 41 ) ) -RRB- cord-010092-uftc8inx 4265 1 blood blood NN cord-010092-uftc8inx 4265 2 donors donor NNS cord-010092-uftc8inx 4265 3 are be VBP cord-010092-uftc8inx 4265 4 not not RB cord-010092-uftc8inx 4265 5 correctly correctly RB cord-010092-uftc8inx 4265 6 informed inform VBN cord-010092-uftc8inx 4265 7 about about IN cord-010092-uftc8inx 4265 8 blood blood NN cord-010092-uftc8inx 4265 9 donation donation NN cord-010092-uftc8inx 4265 10 during during IN cord-010092-uftc8inx 4265 11 sensibilisation sensibilisation NN cord-010092-uftc8inx 4265 12 by by IN cord-010092-uftc8inx 4265 13 family family NN cord-010092-uftc8inx 4265 14 members member NNS cord-010092-uftc8inx 4265 15 of of IN cord-010092-uftc8inx 4265 16 patients patient NNS cord-010092-uftc8inx 4265 17 . . . cord-010092-uftc8inx 4266 1 In in IN cord-010092-uftc8inx 4266 2 the the DT cord-010092-uftc8inx 4266 3 flow flow NN cord-010092-uftc8inx 4266 4 of of IN cord-010092-uftc8inx 4266 5 qualification qualification NN cord-010092-uftc8inx 4266 6 of of IN cord-010092-uftc8inx 4266 7 blood blood NN cord-010092-uftc8inx 4266 8 products product NNS cord-010092-uftc8inx 4266 9 , , , cord-010092-uftc8inx 4266 10 highest high JJS cord-010092-uftc8inx 4266 11 scores score NNS cord-010092-uftc8inx 4266 12 were be VBD cord-010092-uftc8inx 4266 13 made make VBN cord-010092-uftc8inx 4266 14 for for IN cord-010092-uftc8inx 4266 15 : : : cord-010092-uftc8inx 4266 16 ( ( -LRB- cord-010092-uftc8inx 4266 17 i i NN cord-010092-uftc8inx 4266 18 ) ) -RRB- cord-010092-uftc8inx 4267 1 no no DT cord-010092-uftc8inx 4267 2 double double JJ cord-010092-uftc8inx 4267 3 check check NN cord-010092-uftc8inx 4267 4 for for IN cord-010092-uftc8inx 4267 5 validation validation NN cord-010092-uftc8inx 4267 6 and and CC cord-010092-uftc8inx 4267 7 sorting sorting NN cord-010092-uftc8inx 4267 8 of of IN cord-010092-uftc8inx 4267 9 qualified qualified JJ cord-010092-uftc8inx 4267 10 blood blood NN cord-010092-uftc8inx 4267 11 products product NNS cord-010092-uftc8inx 4267 12 , , , cord-010092-uftc8inx 4267 13 ( ( -LRB- cord-010092-uftc8inx 4267 14 ii ii LS cord-010092-uftc8inx 4267 15 ) ) -RRB- cord-010092-uftc8inx 4267 16 stock stock NN cord-010092-uftc8inx 4267 17 - - HYPH cord-010092-uftc8inx 4267 18 out out NN cord-010092-uftc8inx 4267 19 of of IN cord-010092-uftc8inx 4267 20 reagents reagent NNS cord-010092-uftc8inx 4267 21 , , , cord-010092-uftc8inx 4267 22 ( ( -LRB- cord-010092-uftc8inx 4267 23 iii iii NN cord-010092-uftc8inx 4267 24 ) ) -RRB- cord-010092-uftc8inx 4268 1 no no DT cord-010092-uftc8inx 4268 2 check check NN cord-010092-uftc8inx 4268 3 for for IN cord-010092-uftc8inx 4268 4 match match NN cord-010092-uftc8inx 4268 5 between between IN cord-010092-uftc8inx 4268 6 registered registered JJ cord-010092-uftc8inx 4268 7 test test NN cord-010092-uftc8inx 4268 8 result result NN cord-010092-uftc8inx 4268 9 and and CC cord-010092-uftc8inx 4268 10 tested test VBN cord-010092-uftc8inx 4268 11 blood blood NN cord-010092-uftc8inx 4268 12 tube tube NN cord-010092-uftc8inx 4268 13 . . . cord-010092-uftc8inx 4269 1 Regarding regard VBG cord-010092-uftc8inx 4269 2 production production NN cord-010092-uftc8inx 4269 3 of of IN cord-010092-uftc8inx 4269 4 blood blood NN cord-010092-uftc8inx 4269 5 products product NNS cord-010092-uftc8inx 4269 6 , , , cord-010092-uftc8inx 4269 7 the the DT cord-010092-uftc8inx 4269 8 top top JJ cord-010092-uftc8inx 4269 9 three three CD cord-010092-uftc8inx 4269 10 consisted consisted NNS cord-010092-uftc8inx 4269 11 of of IN cord-010092-uftc8inx 4269 12 : : : cord-010092-uftc8inx 4269 13 ( ( -LRB- cord-010092-uftc8inx 4269 14 i i NN cord-010092-uftc8inx 4269 15 ) ) -RRB- cord-010092-uftc8inx 4269 16 transport transport NN cord-010092-uftc8inx 4269 17 time time NN cord-010092-uftc8inx 4269 18 between between IN cord-010092-uftc8inx 4269 19 blood blood NN cord-010092-uftc8inx 4269 20 collection collection NN cord-010092-uftc8inx 4269 21 and and CC cord-010092-uftc8inx 4269 22 processing processing NN cord-010092-uftc8inx 4269 23 is be VBZ cord-010092-uftc8inx 4269 24 > > NNP cord-010092-uftc8inx 4269 25 8 8 CD cord-010092-uftc8inx 4269 26 h h NN cord-010092-uftc8inx 4269 27 , , , cord-010092-uftc8inx 4269 28 ( ( -LRB- cord-010092-uftc8inx 4269 29 ii ii NN cord-010092-uftc8inx 4269 30 ) ) -RRB- cord-010092-uftc8inx 4269 31 storage storage NN cord-010092-uftc8inx 4269 32 of of IN cord-010092-uftc8inx 4269 33 qualified qualified JJ cord-010092-uftc8inx 4269 34 and and CC cord-010092-uftc8inx 4269 35 quarantined quarantine VBD cord-010092-uftc8inx 4269 36 blood blood NN cord-010092-uftc8inx 4269 37 products product NNS cord-010092-uftc8inx 4269 38 in in IN cord-010092-uftc8inx 4269 39 the the DT cord-010092-uftc8inx 4269 40 same same JJ cord-010092-uftc8inx 4269 41 fridge fridge NN cord-010092-uftc8inx 4269 42 ( ( -LRB- cord-010092-uftc8inx 4269 43 some some DT cord-010092-uftc8inx 4269 44 sites site NNS cord-010092-uftc8inx 4269 45 only only RB cord-010092-uftc8inx 4269 46 ) ) -RRB- cord-010092-uftc8inx 4269 47 , , , cord-010092-uftc8inx 4269 48 ( ( -LRB- cord-010092-uftc8inx 4269 49 iii iii NN cord-010092-uftc8inx 4269 50 ) ) -RRB- cord-010092-uftc8inx 4269 51 power power NN cord-010092-uftc8inx 4269 52 cuts cut NNS cord-010092-uftc8inx 4269 53 . . . cord-010092-uftc8inx 4270 1 Summary Summary NNP cord-010092-uftc8inx 4270 2 / / SYM cord-010092-uftc8inx 4270 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 4270 4 : : : cord-010092-uftc8inx 4271 1 The the DT cord-010092-uftc8inx 4271 2 risk risk NN cord-010092-uftc8inx 4271 3 analysis analysis NN cord-010092-uftc8inx 4271 4 resulted result VBD cord-010092-uftc8inx 4271 5 in in IN cord-010092-uftc8inx 4271 6 three three CD cord-010092-uftc8inx 4271 7 prioritized prioritize VBN cord-010092-uftc8inx 4271 8 hazards hazard NNS cord-010092-uftc8inx 4271 9 in in IN cord-010092-uftc8inx 4271 10 the the DT cord-010092-uftc8inx 4271 11 process process NN cord-010092-uftc8inx 4271 12 of of IN cord-010092-uftc8inx 4271 13 donor donor NN cord-010092-uftc8inx 4271 14 selection selection NN cord-010092-uftc8inx 4271 15 / / SYM cord-010092-uftc8inx 4271 16 sensibilisation sensibilisation NN cord-010092-uftc8inx 4271 17 and and CC cord-010092-uftc8inx 4271 18 blood blood NN cord-010092-uftc8inx 4271 19 product product NN cord-010092-uftc8inx 4271 20 qualification qualification NN cord-010092-uftc8inx 4271 21 / / SYM cord-010092-uftc8inx 4271 22 production production NN cord-010092-uftc8inx 4271 23 . . . cord-010092-uftc8inx 4272 1 Some some DT cord-010092-uftc8inx 4272 2 are be VBP cord-010092-uftc8inx 4272 3 very very RB cord-010092-uftc8inx 4272 4 specific specific JJ cord-010092-uftc8inx 4272 5 to to IN cord-010092-uftc8inx 4272 6 the the DT cord-010092-uftc8inx 4272 7 sub sub JJ cord-010092-uftc8inx 4272 8 - - JJ cord-010092-uftc8inx 4272 9 Saharan saharan JJ cord-010092-uftc8inx 4272 10 African african JJ cord-010092-uftc8inx 4272 11 setting set VBG cord-010092-uftc8inx 4272 12 and and CC cord-010092-uftc8inx 4272 13 have have VBP cord-010092-uftc8inx 4272 14 been be VBN cord-010092-uftc8inx 4272 15 described describe VBN cord-010092-uftc8inx 4272 16 before before IN cord-010092-uftc8inx 4272 17 ( ( -LRB- cord-010092-uftc8inx 4272 18 power power NN cord-010092-uftc8inx 4272 19 cut cut NN cord-010092-uftc8inx 4272 20 , , , cord-010092-uftc8inx 4272 21 family family NN cord-010092-uftc8inx 4272 22 and and CC cord-010092-uftc8inx 4272 23 paid pay VBD cord-010092-uftc8inx 4272 24 donors donor NNS cord-010092-uftc8inx 4272 25 , , , cord-010092-uftc8inx 4272 26 stock stock NN cord-010092-uftc8inx 4272 27 rupture rupture NN cord-010092-uftc8inx 4272 28 , , , cord-010092-uftc8inx 4272 29 . . . cord-010092-uftc8inx 4272 30 . . . cord-010092-uftc8inx 4272 31 . . . cord-010092-uftc8inx 4272 32 ) ) -RRB- cord-010092-uftc8inx 4272 33 . . . cord-010092-uftc8inx 4273 1 An an DT cord-010092-uftc8inx 4273 2 action action NN cord-010092-uftc8inx 4273 3 plan plan NN cord-010092-uftc8inx 4273 4 needs need VBZ cord-010092-uftc8inx 4273 5 to to TO cord-010092-uftc8inx 4273 6 be be VB cord-010092-uftc8inx 4273 7 put put VBN cord-010092-uftc8inx 4273 8 in in IN cord-010092-uftc8inx 4273 9 place place NN cord-010092-uftc8inx 4273 10 to to TO cord-010092-uftc8inx 4273 11 reduce reduce VB cord-010092-uftc8inx 4273 12 their -PRON- PRP$ cord-010092-uftc8inx 4273 13 final final JJ cord-010092-uftc8inx 4273 14 risk risk NN cord-010092-uftc8inx 4273 15 score score NN cord-010092-uftc8inx 4273 16 . . . cord-010092-uftc8inx 4274 1 The the DT cord-010092-uftc8inx 4274 2 risk risk NN cord-010092-uftc8inx 4274 3 analysis analysis NN cord-010092-uftc8inx 4274 4 needs need VBZ cord-010092-uftc8inx 4274 5 to to TO cord-010092-uftc8inx 4274 6 be be VB cord-010092-uftc8inx 4274 7 continued continue VBN cord-010092-uftc8inx 4274 8 for for IN cord-010092-uftc8inx 4274 9 the the DT cord-010092-uftc8inx 4274 10 remaining remain VBG cord-010092-uftc8inx 4274 11 blood blood NN cord-010092-uftc8inx 4274 12 transfusion transfusion NN cord-010092-uftc8inx 4274 13 flows flow NNS cord-010092-uftc8inx 4274 14 . . . cord-010092-uftc8inx 4275 1 Background background NN cord-010092-uftc8inx 4275 2 : : : cord-010092-uftc8inx 4276 1 19.3 19.3 CD cord-010092-uftc8inx 4276 2 million million CD cord-010092-uftc8inx 4276 3 of of IN cord-010092-uftc8inx 4276 4 Germany Germany NNP cord-010092-uftc8inx 4276 5 's 's POS cord-010092-uftc8inx 4276 6 population population NN cord-010092-uftc8inx 4276 7 , , , cord-010092-uftc8inx 4276 8 so so RB cord-010092-uftc8inx 4276 9 just just RB cord-010092-uftc8inx 4276 10 under under IN cord-010092-uftc8inx 4276 11 a a DT cord-010092-uftc8inx 4276 12 quarter quarter NN cord-010092-uftc8inx 4276 13 of of IN cord-010092-uftc8inx 4276 14 residents resident NNS cord-010092-uftc8inx 4276 15 , , , cord-010092-uftc8inx 4276 16 have have VBP cord-010092-uftc8inx 4276 17 a a DT cord-010092-uftc8inx 4276 18 migration migration NN cord-010092-uftc8inx 4276 19 background background NN cord-010092-uftc8inx 4276 20 . . . cord-010092-uftc8inx 4277 1 The the DT cord-010092-uftc8inx 4277 2 majority majority NN cord-010092-uftc8inx 4277 3 of of IN cord-010092-uftc8inx 4277 4 these these DT cord-010092-uftc8inx 4277 5 has have VBZ cord-010092-uftc8inx 4277 6 roots root NNS cord-010092-uftc8inx 4277 7 in in IN cord-010092-uftc8inx 4277 8 regions region NNS cord-010092-uftc8inx 4277 9 where where WRB cord-010092-uftc8inx 4277 10 the the DT cord-010092-uftc8inx 4277 11 population population NN cord-010092-uftc8inx 4277 12 has have VBZ cord-010092-uftc8inx 4277 13 a a DT cord-010092-uftc8inx 4277 14 distribution distribution NN cord-010092-uftc8inx 4277 15 pattern pattern NN cord-010092-uftc8inx 4277 16 of of IN cord-010092-uftc8inx 4277 17 blood blood NN cord-010092-uftc8inx 4277 18 group group NN cord-010092-uftc8inx 4277 19 and and CC cord-010092-uftc8inx 4277 20 HLA HLA NNP cord-010092-uftc8inx 4277 21 - - HYPH cord-010092-uftc8inx 4277 22 antigens antigen NNS cord-010092-uftc8inx 4277 23 that that WDT cord-010092-uftc8inx 4277 24 differs differ VBZ cord-010092-uftc8inx 4277 25 considerably considerably RB cord-010092-uftc8inx 4277 26 from from IN cord-010092-uftc8inx 4277 27 the the DT cord-010092-uftc8inx 4277 28 predominant predominant JJ cord-010092-uftc8inx 4277 29 one one NN cord-010092-uftc8inx 4277 30 in in IN cord-010092-uftc8inx 4277 31 the the DT cord-010092-uftc8inx 4277 32 German german JJ cord-010092-uftc8inx 4277 33 population population NN cord-010092-uftc8inx 4277 34 . . . cord-010092-uftc8inx 4278 1 Sufficient sufficient JJ cord-010092-uftc8inx 4278 2 supply supply NN cord-010092-uftc8inx 4278 3 of of IN cord-010092-uftc8inx 4278 4 these these DT cord-010092-uftc8inx 4278 5 individuals individual NNS cord-010092-uftc8inx 4278 6 with with IN cord-010092-uftc8inx 4278 7 red red JJ cord-010092-uftc8inx 4278 8 blood blood NN cord-010092-uftc8inx 4278 9 cell cell NN cord-010092-uftc8inx 4278 10 ( ( -LRB- cord-010092-uftc8inx 4278 11 RBC RBC NNP cord-010092-uftc8inx 4278 12 ) ) -RRB- cord-010092-uftc8inx 4278 13 and and CC cord-010092-uftc8inx 4278 14 platelet platelet NN cord-010092-uftc8inx 4278 15 concentrates concentrate NNS cord-010092-uftc8inx 4278 16 ( ( -LRB- cord-010092-uftc8inx 4278 17 TC TC NNP cord-010092-uftc8inx 4278 18 ) ) -RRB- cord-010092-uftc8inx 4278 19 will will MD cord-010092-uftc8inx 4278 20 continue continue VB cord-010092-uftc8inx 4278 21 to to TO cord-010092-uftc8inx 4278 22 be be VB cord-010092-uftc8inx 4278 23 a a DT cord-010092-uftc8inx 4278 24 major major JJ cord-010092-uftc8inx 4278 25 challenge challenge NN cord-010092-uftc8inx 4278 26 in in IN cord-010092-uftc8inx 4278 27 the the DT cord-010092-uftc8inx 4278 28 future future NN cord-010092-uftc8inx 4278 29 , , , cord-010092-uftc8inx 4278 30 as as IN cord-010092-uftc8inx 4278 31 blood blood NN cord-010092-uftc8inx 4278 32 donors donor NNS cord-010092-uftc8inx 4278 33 with with IN cord-010092-uftc8inx 4278 34 compatible compatible JJ cord-010092-uftc8inx 4278 35 blood blood NN cord-010092-uftc8inx 4278 36 group group NN cord-010092-uftc8inx 4278 37 antigens antigen NNS cord-010092-uftc8inx 4278 38 are be VBP cord-010092-uftc8inx 4278 39 dramatically dramatically RB cord-010092-uftc8inx 4278 40 underrepresented underrepresented JJ cord-010092-uftc8inx 4278 41 in in IN cord-010092-uftc8inx 4278 42 the the DT cord-010092-uftc8inx 4278 43 local local JJ cord-010092-uftc8inx 4278 44 donor donor NN cord-010092-uftc8inx 4278 45 pools pool NNS cord-010092-uftc8inx 4278 46 . . . cord-010092-uftc8inx 4279 1 Many many JJ cord-010092-uftc8inx 4279 2 migrants migrant NNS cord-010092-uftc8inx 4279 3 suffer suffer VBP cord-010092-uftc8inx 4279 4 from from IN cord-010092-uftc8inx 4279 5 severe severe JJ cord-010092-uftc8inx 4279 6 hematological hematological JJ cord-010092-uftc8inx 4279 7 disorders disorder NNS cord-010092-uftc8inx 4279 8 such such JJ cord-010092-uftc8inx 4279 9 as as IN cord-010092-uftc8inx 4279 10 b b NN cord-010092-uftc8inx 4279 11 - - HYPH cord-010092-uftc8inx 4279 12 thalassemia thalassemia NN cord-010092-uftc8inx 4279 13 or or CC cord-010092-uftc8inx 4279 14 sickle sickle NN cord-010092-uftc8inx 4279 15 cell cell NN cord-010092-uftc8inx 4279 16 disease disease NN cord-010092-uftc8inx 4279 17 and and CC cord-010092-uftc8inx 4279 18 will will MD cord-010092-uftc8inx 4279 19 not not RB cord-010092-uftc8inx 4279 20 only only RB cord-010092-uftc8inx 4279 21 need need VB cord-010092-uftc8inx 4279 22 compatible compatible JJ cord-010092-uftc8inx 4279 23 blood blood NN cord-010092-uftc8inx 4279 24 transfusions transfusion NNS cord-010092-uftc8inx 4279 25 , , , cord-010092-uftc8inx 4279 26 but but CC cord-010092-uftc8inx 4279 27 an an DT cord-010092-uftc8inx 4279 28 allogeneic allogeneic NN cord-010092-uftc8inx 4279 29 stem stem NN cord-010092-uftc8inx 4279 30 cell cell NN cord-010092-uftc8inx 4279 31 transplantation transplantation NN cord-010092-uftc8inx 4279 32 in in IN cord-010092-uftc8inx 4279 33 the the DT cord-010092-uftc8inx 4279 34 foreseeable foreseeable JJ cord-010092-uftc8inx 4279 35 future future NN cord-010092-uftc8inx 4279 36 . . . cord-010092-uftc8inx 4280 1 As as IN cord-010092-uftc8inx 4280 2 healthy healthy JJ cord-010092-uftc8inx 4280 3 family family NN cord-010092-uftc8inx 4280 4 donors donor NNS cord-010092-uftc8inx 4280 5 often often RB cord-010092-uftc8inx 4280 6 are be VBP cord-010092-uftc8inx 4280 7 not not RB cord-010092-uftc8inx 4280 8 available available JJ cord-010092-uftc8inx 4280 9 , , , cord-010092-uftc8inx 4280 10 at at IN cord-010092-uftc8inx 4280 11 present present JJ cord-010092-uftc8inx 4280 12 suitable suitable JJ cord-010092-uftc8inx 4280 13 stem stem NN cord-010092-uftc8inx 4280 14 cell cell NN cord-010092-uftc8inx 4280 15 donors donor NNS cord-010092-uftc8inx 4280 16 with with IN cord-010092-uftc8inx 4280 17 a a DT cord-010092-uftc8inx 4280 18 similar similar JJ cord-010092-uftc8inx 4280 19 genetic genetic JJ cord-010092-uftc8inx 4280 20 background background NN cord-010092-uftc8inx 4280 21 can can MD cord-010092-uftc8inx 4280 22 only only RB cord-010092-uftc8inx 4280 23 be be VB cord-010092-uftc8inx 4280 24 found find VBN cord-010092-uftc8inx 4280 25 in in IN cord-010092-uftc8inx 4280 26 international international JJ cord-010092-uftc8inx 4280 27 donor donor NN cord-010092-uftc8inx 4280 28 registries registry NNS cord-010092-uftc8inx 4280 29 . . . cord-010092-uftc8inx 4281 1 Aims aim VBZ cord-010092-uftc8inx 4281 2 : : : cord-010092-uftc8inx 4282 1 This this DT cord-010092-uftc8inx 4282 2 project project NN cord-010092-uftc8inx 4282 3 was be VBD cord-010092-uftc8inx 4282 4 initiated initiate VBN cord-010092-uftc8inx 4282 5 to to TO cord-010092-uftc8inx 4282 6 recruit recruit VB cord-010092-uftc8inx 4282 7 new new JJ cord-010092-uftc8inx 4282 8 donors donor NNS cord-010092-uftc8inx 4282 9 with with IN cord-010092-uftc8inx 4282 10 a a DT cord-010092-uftc8inx 4282 11 migration migration NN cord-010092-uftc8inx 4282 12 background background NN cord-010092-uftc8inx 4282 13 for for IN cord-010092-uftc8inx 4282 14 blood blood NN cord-010092-uftc8inx 4282 15 donation donation NN cord-010092-uftc8inx 4282 16 and and CC cord-010092-uftc8inx 4282 17 to to TO cord-010092-uftc8inx 4282 18 increase increase VB cord-010092-uftc8inx 4282 19 the the DT cord-010092-uftc8inx 4282 20 number number NN cord-010092-uftc8inx 4282 21 of of IN cord-010092-uftc8inx 4282 22 blood blood NN cord-010092-uftc8inx 4282 23 stem stem NN cord-010092-uftc8inx 4282 24 cell cell NN cord-010092-uftc8inx 4282 25 donors donor NNS cord-010092-uftc8inx 4282 26 among among IN cord-010092-uftc8inx 4282 27 this this DT cord-010092-uftc8inx 4282 28 group group NN cord-010092-uftc8inx 4282 29 . . . cord-010092-uftc8inx 4283 1 Methods method NNS cord-010092-uftc8inx 4283 2 : : : cord-010092-uftc8inx 4283 3 Serological serological JJ cord-010092-uftc8inx 4283 4 extended extended JJ cord-010092-uftc8inx 4283 5 blood blood NN cord-010092-uftc8inx 4283 6 group group NN cord-010092-uftc8inx 4283 7 phenotyping phenotyping NN cord-010092-uftc8inx 4283 8 was be VBD cord-010092-uftc8inx 4283 9 performed perform VBN cord-010092-uftc8inx 4283 10 by by IN cord-010092-uftc8inx 4283 11 automated automate VBN cord-010092-uftc8inx 4283 12 gel gel NN cord-010092-uftc8inx 4283 13 card card NN cord-010092-uftc8inx 4283 14 technique technique NN cord-010092-uftc8inx 4283 15 ( ( -LRB- cord-010092-uftc8inx 4283 16 Fa Fa NNP cord-010092-uftc8inx 4283 17 . . . cord-010092-uftc8inx 4284 1 Grifols Grifols NNP cord-010092-uftc8inx 4284 2 , , , cord-010092-uftc8inx 4284 3 Erytra Erytra NNP cord-010092-uftc8inx 4284 4 ) ) -RRB- cord-010092-uftc8inx 4284 5 and and CC cord-010092-uftc8inx 4284 6 included include VBD cord-010092-uftc8inx 4284 7 AB0 AB0 NNP cord-010092-uftc8inx 4284 8 , , , cord-010092-uftc8inx 4284 9 Rh Rh NNP cord-010092-uftc8inx 4284 10 ( ( -LRB- cord-010092-uftc8inx 4284 11 CcDEe CcDEe NNP cord-010092-uftc8inx 4284 12 ) ) -RRB- cord-010092-uftc8inx 4284 13 , , , cord-010092-uftc8inx 4284 14 Kk Kk NNP cord-010092-uftc8inx 4284 15 , , , cord-010092-uftc8inx 4284 16 Fy Fy NNP cord-010092-uftc8inx 4284 17 ( ( -LRB- cord-010092-uftc8inx 4284 18 ab ab NN cord-010092-uftc8inx 4284 19 ) ) -RRB- cord-010092-uftc8inx 4284 20 , , , cord-010092-uftc8inx 4284 21 Jk(ab Jk(ab NNP cord-010092-uftc8inx 4284 22 ) ) -RRB- cord-010092-uftc8inx 4284 23 , , , cord-010092-uftc8inx 4284 24 Lu(ab Lu(ab NNP cord-010092-uftc8inx 4284 25 ) ) -RRB- cord-010092-uftc8inx 4284 26 , , , cord-010092-uftc8inx 4284 27 M M NNP cord-010092-uftc8inx 4284 28 , , , cord-010092-uftc8inx 4284 29 N N NNP cord-010092-uftc8inx 4284 30 , , , cord-010092-uftc8inx 4284 31 S S NNP cord-010092-uftc8inx 4284 32 , , , cord-010092-uftc8inx 4284 33 s. s. NNP cord-010092-uftc8inx 4284 34 HLA HLA NNP cord-010092-uftc8inx 4284 35 typing type VBG cord-010092-uftc8inx 4284 36 for for IN cord-010092-uftc8inx 4284 37 HLA HLA NNP cord-010092-uftc8inx 4284 38 - - HYPH cord-010092-uftc8inx 4284 39 A A NNP cord-010092-uftc8inx 4284 40 , , , cord-010092-uftc8inx 4284 41 -B -b ADD cord-010092-uftc8inx 4284 42 , , , cord-010092-uftc8inx 4284 43 -C -C NNS cord-010092-uftc8inx 4284 44 , , , cord-010092-uftc8inx 4284 45 -DR -dr NN cord-010092-uftc8inx 4284 46 , , , cord-010092-uftc8inx 4284 47 -DQ -dq NN cord-010092-uftc8inx 4284 48 , , , cord-010092-uftc8inx 4284 49 and and CC cord-010092-uftc8inx 4284 50 -DP -DP NNS cord-010092-uftc8inx 4284 51 was be VBD cord-010092-uftc8inx 4284 52 performed perform VBN cord-010092-uftc8inx 4284 53 by by IN cord-010092-uftc8inx 4284 54 Next Next NNP cord-010092-uftc8inx 4284 55 Generation Generation NNP cord-010092-uftc8inx 4284 56 Sequencing Sequencing NNP cord-010092-uftc8inx 4284 57 . . . cord-010092-uftc8inx 4285 1 Allele allele NN cord-010092-uftc8inx 4285 2 frequencies frequency NNS cord-010092-uftc8inx 4285 3 were be VBD cord-010092-uftc8inx 4285 4 analysed analyse VBN cord-010092-uftc8inx 4285 5 using use VBG cord-010092-uftc8inx 4285 6 Genepop Genepop NNP cord-010092-uftc8inx 4285 7 Version Version NNP cord-010092-uftc8inx 4285 8 4.2 4.2 CD cord-010092-uftc8inx 4285 9 ; ; : cord-010092-uftc8inx 4285 10 the the DT cord-010092-uftc8inx 4285 11 rare rare JJ cord-010092-uftc8inx 4285 12 and and CC cord-010092-uftc8inx 4285 13 very very RB cord-010092-uftc8inx 4285 14 rare rare JJ cord-010092-uftc8inx 4285 15 alleles allele NNS cord-010092-uftc8inx 4285 16 were be VBD cord-010092-uftc8inx 4285 17 defined define VBN cord-010092-uftc8inx 4285 18 according accord VBG cord-010092-uftc8inx 4285 19 to to IN cord-010092-uftc8inx 4285 20 the the DT cord-010092-uftc8inx 4285 21 Allele Allele NNP cord-010092-uftc8inx 4285 22 Frequency Frequency NNP cord-010092-uftc8inx 4285 23 Database Database NNP cord-010092-uftc8inx 4285 24 ( ( -LRB- cord-010092-uftc8inx 4285 25 www.allelefrequencies.net www.allelefrequencies.net NN cord-010092-uftc8inx 4285 26 ) ) -RRB- cord-010092-uftc8inx 4285 27 RBC RBC NNP cord-010092-uftc8inx 4285 28 genotyping genotyping NN cord-010092-uftc8inx 4285 29 using use VBG cord-010092-uftc8inx 4285 30 Next Next NNP cord-010092-uftc8inx 4285 31 Generation Generation NNP cord-010092-uftc8inx 4285 32 Sequencing Sequencing NNP cord-010092-uftc8inx 4285 33 is be VBZ cord-010092-uftc8inx 4285 34 currently currently RB cord-010092-uftc8inx 4285 35 being be VBG cord-010092-uftc8inx 4285 36 established establish VBN cord-010092-uftc8inx 4285 37 and and CC cord-010092-uftc8inx 4285 38 will will MD cord-010092-uftc8inx 4285 39 include include VB cord-010092-uftc8inx 4285 40 additional additional JJ cord-010092-uftc8inx 4285 41 antigens antigen NNS cord-010092-uftc8inx 4285 42 with with IN cord-010092-uftc8inx 4285 43 the the DT cord-010092-uftc8inx 4285 44 most most RBS cord-010092-uftc8inx 4285 45 frequent frequent JJ cord-010092-uftc8inx 4285 46 distribution distribution NN cord-010092-uftc8inx 4285 47 pattern pattern NN cord-010092-uftc8inx 4285 48 differences difference NNS cord-010092-uftc8inx 4285 49 between between IN cord-010092-uftc8inx 4285 50 migrant migrant NN cord-010092-uftc8inx 4285 51 and and CC cord-010092-uftc8inx 4285 52 resident resident JJ cord-010092-uftc8inx 4285 53 populations population NNS cord-010092-uftc8inx 4285 54 according accord VBG cord-010092-uftc8inx 4285 55 to to IN cord-010092-uftc8inx 4285 56 literature literature NN cord-010092-uftc8inx 4285 57 . . . cord-010092-uftc8inx 4286 1 Results result NNS cord-010092-uftc8inx 4286 2 : : : cord-010092-uftc8inx 4287 1 So so RB cord-010092-uftc8inx 4287 2 far far RB cord-010092-uftc8inx 4287 3 , , , cord-010092-uftc8inx 4287 4 more more JJR cord-010092-uftc8inx 4287 5 than than IN cord-010092-uftc8inx 4287 6 8800 8800 CD cord-010092-uftc8inx 4287 7 blood blood NN cord-010092-uftc8inx 4287 8 donors donor NNS cord-010092-uftc8inx 4287 9 with with IN cord-010092-uftc8inx 4287 10 a a DT cord-010092-uftc8inx 4287 11 migration migration NN cord-010092-uftc8inx 4287 12 background background NN cord-010092-uftc8inx 4287 13 have have VBP cord-010092-uftc8inx 4287 14 been be VBN cord-010092-uftc8inx 4287 15 recruited recruit VBN cord-010092-uftc8inx 4287 16 for for IN cord-010092-uftc8inx 4287 17 a a DT cord-010092-uftc8inx 4287 18 blood blood NN cord-010092-uftc8inx 4287 19 donation donation NN cord-010092-uftc8inx 4287 20 in in IN cord-010092-uftc8inx 4287 21 this this DT cord-010092-uftc8inx 4287 22 project project NN cord-010092-uftc8inx 4287 23 . . . cord-010092-uftc8inx 4288 1 Amongst amongst IN cord-010092-uftc8inx 4288 2 this this DT cord-010092-uftc8inx 4288 3 group group NN cord-010092-uftc8inx 4288 4 , , , cord-010092-uftc8inx 4288 5 over over IN cord-010092-uftc8inx 4288 6 1000 1000 CD cord-010092-uftc8inx 4288 7 blood blood NN cord-010092-uftc8inx 4288 8 donors donor NNS cord-010092-uftc8inx 4288 9 from from IN cord-010092-uftc8inx 4288 10 more more JJR cord-010092-uftc8inx 4288 11 than than IN cord-010092-uftc8inx 4288 12 20 20 CD cord-010092-uftc8inx 4288 13 non non JJ cord-010092-uftc8inx 4288 14 - - JJ cord-010092-uftc8inx 4288 15 European european JJ cord-010092-uftc8inx 4288 16 countries country NNS cord-010092-uftc8inx 4288 17 enrolled enrol VBN cord-010092-uftc8inx 4288 18 as as IN cord-010092-uftc8inx 4288 19 potential potential JJ cord-010092-uftc8inx 4288 20 stem stem NN cord-010092-uftc8inx 4288 21 cell cell NN cord-010092-uftc8inx 4288 22 donors donor NNS cord-010092-uftc8inx 4288 23 . . . cord-010092-uftc8inx 4289 1 An an DT cord-010092-uftc8inx 4289 2 initial initial JJ cord-010092-uftc8inx 4289 3 evaluation evaluation NN cord-010092-uftc8inx 4289 4 of of IN cord-010092-uftc8inx 4289 5 the the DT cord-010092-uftc8inx 4289 6 data datum NNS cord-010092-uftc8inx 4289 7 revealed reveal VBD cord-010092-uftc8inx 4289 8 a a DT cord-010092-uftc8inx 4289 9 very very RB cord-010092-uftc8inx 4289 10 similar similar JJ cord-010092-uftc8inx 4289 11 distribution distribution NN cord-010092-uftc8inx 4289 12 of of IN cord-010092-uftc8inx 4289 13 blood blood NN cord-010092-uftc8inx 4289 14 groups group NNS cord-010092-uftc8inx 4289 15 compared compare VBN cord-010092-uftc8inx 4289 16 to to IN cord-010092-uftc8inx 4289 17 the the DT cord-010092-uftc8inx 4289 18 current current JJ cord-010092-uftc8inx 4289 19 blood blood NN cord-010092-uftc8inx 4289 20 donor donor NN cord-010092-uftc8inx 4289 21 population population NN cord-010092-uftc8inx 4289 22 in in IN cord-010092-uftc8inx 4289 23 North North NNP cord-010092-uftc8inx 4289 24 Rhine Rhine NNP cord-010092-uftc8inx 4289 25 - - HYPH cord-010092-uftc8inx 4289 26 Westphalia Westphalia NNP cord-010092-uftc8inx 4289 27 . . . cord-010092-uftc8inx 4290 1 Of of IN cord-010092-uftc8inx 4290 2 600 600 CD cord-010092-uftc8inx 4290 3 migrant migrant JJ cord-010092-uftc8inx 4290 4 donors donor NNS cord-010092-uftc8inx 4290 5 , , , cord-010092-uftc8inx 4290 6 ten ten CD cord-010092-uftc8inx 4290 7 Fy(a Fy(a NNP cord-010092-uftc8inx 4290 8 - - HYPH cord-010092-uftc8inx 4290 9 b- b- NNP cord-010092-uftc8inx 4290 10 ) ) -RRB- cord-010092-uftc8inx 4291 1 donors donor NNS cord-010092-uftc8inx 4291 2 were be VBD cord-010092-uftc8inx 4291 3 identified identify VBN cord-010092-uftc8inx 4291 4 , , , cord-010092-uftc8inx 4291 5 which which WDT cord-010092-uftc8inx 4291 6 corresponds correspond VBZ cord-010092-uftc8inx 4291 7 to to IN cord-010092-uftc8inx 4291 8 a a DT cord-010092-uftc8inx 4291 9 percentage percentage NN cord-010092-uftc8inx 4291 10 of of IN cord-010092-uftc8inx 4291 11 1.6 1.6 CD cord-010092-uftc8inx 4291 12 % % NN cord-010092-uftc8inx 4291 13 . . . cord-010092-uftc8inx 4292 1 Amongst amongst IN cord-010092-uftc8inx 4292 2 509 509 CD cord-010092-uftc8inx 4292 3 HLA HLA NNP cord-010092-uftc8inx 4292 4 - - HYPH cord-010092-uftc8inx 4292 5 typed type VBN cord-010092-uftc8inx 4292 6 potential potential JJ cord-010092-uftc8inx 4292 7 stem stem NN cord-010092-uftc8inx 4292 8 cell cell NN cord-010092-uftc8inx 4292 9 donors donor NNS cord-010092-uftc8inx 4292 10 , , , cord-010092-uftc8inx 4292 11 we -PRON- PRP cord-010092-uftc8inx 4292 12 found find VBD cord-010092-uftc8inx 4292 13 28 28 CD cord-010092-uftc8inx 4292 14 ( ( -LRB- cord-010092-uftc8inx 4292 15 5.5 5.5 CD cord-010092-uftc8inx 4292 16 % % NN cord-010092-uftc8inx 4292 17 ) ) -RRB- cord-010092-uftc8inx 4292 18 with with IN cord-010092-uftc8inx 4292 19 rare rare JJ cord-010092-uftc8inx 4292 20 and and CC cord-010092-uftc8inx 4292 21 very very RB cord-010092-uftc8inx 4292 22 rare rare JJ cord-010092-uftc8inx 4292 23 alleles allele NNS cord-010092-uftc8inx 4292 24 . . . cord-010092-uftc8inx 4293 1 Summary Summary NNP cord-010092-uftc8inx 4293 2 / / SYM cord-010092-uftc8inx 4293 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 4293 4 : : : cord-010092-uftc8inx 4294 1 Blood blood NN cord-010092-uftc8inx 4294 2 donors donor NNS cord-010092-uftc8inx 4294 3 with with IN cord-010092-uftc8inx 4294 4 rare rare JJ cord-010092-uftc8inx 4294 5 blood blood NN cord-010092-uftc8inx 4294 6 group group NN cord-010092-uftc8inx 4294 7 and and CC cord-010092-uftc8inx 4294 8 HLA HLA NNP cord-010092-uftc8inx 4294 9 phenotypes phenotype NNS cord-010092-uftc8inx 4294 10 ( ( -LRB- cord-010092-uftc8inx 4294 11 e.g. e.g. IN cord-010092-uftc8inx 4294 12 null null JJ cord-010092-uftc8inx 4294 13 types type NNS cord-010092-uftc8inx 4294 14 such such JJ cord-010092-uftc8inx 4294 15 as as IN cord-010092-uftc8inx 4294 16 Fy(a Fy(a NNP cord-010092-uftc8inx 4294 17 - - HYPH cord-010092-uftc8inx 4294 18 b- b- NNP cord-010092-uftc8inx 4294 19 ) ) -RRB- cord-010092-uftc8inx 4294 20 ) ) -RRB- cord-010092-uftc8inx 4294 21 , , , cord-010092-uftc8inx 4294 22 are be VBP cord-010092-uftc8inx 4294 23 in in IN cord-010092-uftc8inx 4294 24 demand demand NN cord-010092-uftc8inx 4294 25 for for IN cord-010092-uftc8inx 4294 26 adequate adequate JJ cord-010092-uftc8inx 4294 27 medical medical JJ cord-010092-uftc8inx 4294 28 care care NN cord-010092-uftc8inx 4294 29 of of IN cord-010092-uftc8inx 4294 30 people people NNS cord-010092-uftc8inx 4294 31 with with IN cord-010092-uftc8inx 4294 32 a a DT cord-010092-uftc8inx 4294 33 migration migration NN cord-010092-uftc8inx 4294 34 background background NN cord-010092-uftc8inx 4294 35 . . . cord-010092-uftc8inx 4295 1 The the DT cord-010092-uftc8inx 4295 2 technological technological JJ cord-010092-uftc8inx 4295 3 development development NN cord-010092-uftc8inx 4295 4 of of IN cord-010092-uftc8inx 4295 5 blood blood NN cord-010092-uftc8inx 4295 6 group group NN cord-010092-uftc8inx 4295 7 determination determination NN cord-010092-uftc8inx 4295 8 by by IN cord-010092-uftc8inx 4295 9 Next Next NNP cord-010092-uftc8inx 4295 10 Generation Generation NNP cord-010092-uftc8inx 4295 11 Sequencing Sequencing NNP cord-010092-uftc8inx 4295 12 will will MD cord-010092-uftc8inx 4295 13 significantly significantly RB cord-010092-uftc8inx 4295 14 improve improve VB cord-010092-uftc8inx 4295 15 the the DT cord-010092-uftc8inx 4295 16 supply supply NN cord-010092-uftc8inx 4295 17 for for IN cord-010092-uftc8inx 4295 18 all all DT cord-010092-uftc8inx 4295 19 blood blood NN cord-010092-uftc8inx 4295 20 transfusion transfusion NN cord-010092-uftc8inx 4295 21 recipients recipient NNS cord-010092-uftc8inx 4295 22 in in IN cord-010092-uftc8inx 4295 23 Germany Germany NNP cord-010092-uftc8inx 4295 24 . . . cord-010092-uftc8inx 4296 1 This this DT cord-010092-uftc8inx 4296 2 project project NN cord-010092-uftc8inx 4296 3 is be VBZ cord-010092-uftc8inx 4296 4 funded fund VBN cord-010092-uftc8inx 4296 5 by by IN cord-010092-uftc8inx 4296 6 the the DT cord-010092-uftc8inx 4296 7 European European NNP cord-010092-uftc8inx 4296 8 Development Development NNP cord-010092-uftc8inx 4296 9 Fund Fund NNP cord-010092-uftc8inx 4296 10 2014 2014 CD cord-010092-uftc8inx 4296 11 - - HYPH cord-010092-uftc8inx 4296 12 2020 2020 CD cord-010092-uftc8inx 4296 13 ( ( -LRB- cord-010092-uftc8inx 4296 14 ERDF ERDF NNP cord-010092-uftc8inx 4296 15 ) ) -RRB- cord-010092-uftc8inx 4296 16 and and CC cord-010092-uftc8inx 4296 17 the the DT cord-010092-uftc8inx 4296 18 European European NNP cord-010092-uftc8inx 4296 19 Union Union NNP cord-010092-uftc8inx 4296 20 . . . cord-010092-uftc8inx 4297 1 Background background NN cord-010092-uftc8inx 4297 2 : : : cord-010092-uftc8inx 4298 1 Mortality mortality NN cord-010092-uftc8inx 4298 2 due due IN cord-010092-uftc8inx 4298 3 to to IN cord-010092-uftc8inx 4298 4 uncontrolled uncontrolled JJ cord-010092-uftc8inx 4298 5 haemorrhage haemorrhage NN cord-010092-uftc8inx 4298 6 following follow VBG cord-010092-uftc8inx 4298 7 trauma trauma NN cord-010092-uftc8inx 4298 8 is be VBZ cord-010092-uftc8inx 4298 9 the the DT cord-010092-uftc8inx 4298 10 most most RBS cord-010092-uftc8inx 4298 11 important important JJ cord-010092-uftc8inx 4298 12 cause cause NN cord-010092-uftc8inx 4298 13 of of IN cord-010092-uftc8inx 4298 14 potentially potentially RB cord-010092-uftc8inx 4298 15 preventable preventable JJ cord-010092-uftc8inx 4298 16 deaths death NNS cord-010092-uftc8inx 4298 17 . . . cord-010092-uftc8inx 4299 1 Trauma trauma NN cord-010092-uftc8inx 4299 2 care care NN cord-010092-uftc8inx 4299 3 systems system NNS cord-010092-uftc8inx 4299 4 in in IN cord-010092-uftc8inx 4299 5 Low Low NNP cord-010092-uftc8inx 4299 6 and and CC cord-010092-uftc8inx 4299 7 Middle Middle NNP cord-010092-uftc8inx 4299 8 Income Income NNP cord-010092-uftc8inx 4299 9 countries country NNS cord-010092-uftc8inx 4299 10 like like IN cord-010092-uftc8inx 4299 11 India India NNP cord-010092-uftc8inx 4299 12 , , , cord-010092-uftc8inx 4299 13 are be VBP cord-010092-uftc8inx 4299 14 still still RB cord-010092-uftc8inx 4299 15 in in IN cord-010092-uftc8inx 4299 16 developing develop VBG cord-010092-uftc8inx 4299 17 phase phase NN cord-010092-uftc8inx 4299 18 . . . cord-010092-uftc8inx 4300 1 Also also RB cord-010092-uftc8inx 4300 2 , , , cord-010092-uftc8inx 4300 3 the the DT cord-010092-uftc8inx 4300 4 role role NN cord-010092-uftc8inx 4300 5 of of IN cord-010092-uftc8inx 4300 6 blood blood NN cord-010092-uftc8inx 4300 7 component component NN cord-010092-uftc8inx 4300 8 therapy therapy NN cord-010092-uftc8inx 4300 9 in in IN cord-010092-uftc8inx 4300 10 improving improve VBG cord-010092-uftc8inx 4300 11 patient patient JJ cord-010092-uftc8inx 4300 12 outcomes outcome NNS cord-010092-uftc8inx 4300 13 has have VBZ cord-010092-uftc8inx 4300 14 been be VBN cord-010092-uftc8inx 4300 15 mostly mostly RB cord-010092-uftc8inx 4300 16 derived derive VBN cord-010092-uftc8inx 4300 17 from from IN cord-010092-uftc8inx 4300 18 combat combat NN cord-010092-uftc8inx 4300 19 settings setting NNS cord-010092-uftc8inx 4300 20 . . . cord-010092-uftc8inx 4301 1 Application application NN cord-010092-uftc8inx 4301 2 of of IN cord-010092-uftc8inx 4301 3 these these DT cord-010092-uftc8inx 4301 4 protocols protocol NNS cord-010092-uftc8inx 4301 5 in in IN cord-010092-uftc8inx 4301 6 an an DT cord-010092-uftc8inx 4301 7 urban urban JJ cord-010092-uftc8inx 4301 8 setup setup NN cord-010092-uftc8inx 4301 9 has have VBZ cord-010092-uftc8inx 4301 10 not not RB cord-010092-uftc8inx 4301 11 been be VBN cord-010092-uftc8inx 4301 12 well well RB cord-010092-uftc8inx 4301 13 established establish VBN cord-010092-uftc8inx 4301 14 and and CC cord-010092-uftc8inx 4301 15 marked marked JJ cord-010092-uftc8inx 4301 16 variation variation NN cord-010092-uftc8inx 4301 17 in in IN cord-010092-uftc8inx 4301 18 practice practice NN cord-010092-uftc8inx 4301 19 exists exist VBZ cord-010092-uftc8inx 4301 20 . . . cord-010092-uftc8inx 4302 1 Hence hence RB cord-010092-uftc8inx 4302 2 this this DT cord-010092-uftc8inx 4302 3 study study NN cord-010092-uftc8inx 4302 4 aims aim VBZ cord-010092-uftc8inx 4302 5 to to TO cord-010092-uftc8inx 4302 6 identify identify VB cord-010092-uftc8inx 4302 7 the the DT cord-010092-uftc8inx 4302 8 key key JJ cord-010092-uftc8inx 4302 9 components component NNS cord-010092-uftc8inx 4302 10 of of IN cord-010092-uftc8inx 4302 11 transfusion transfusion NN cord-010092-uftc8inx 4302 12 practices practice NNS cord-010092-uftc8inx 4302 13 to to TO cord-010092-uftc8inx 4302 14 optimize optimize VB cord-010092-uftc8inx 4302 15 the the DT cord-010092-uftc8inx 4302 16 transfusion transfusion NN cord-010092-uftc8inx 4302 17 protocol protocol NN cord-010092-uftc8inx 4302 18 in in IN cord-010092-uftc8inx 4302 19 trauma trauma NN cord-010092-uftc8inx 4302 20 settings setting NNS cord-010092-uftc8inx 4302 21 . . . cord-010092-uftc8inx 4303 1 Aims aim VBZ cord-010092-uftc8inx 4303 2 : : : cord-010092-uftc8inx 4304 1 To to TO cord-010092-uftc8inx 4304 2 study study VB cord-010092-uftc8inx 4304 3 the the DT cord-010092-uftc8inx 4304 4 current current JJ cord-010092-uftc8inx 4304 5 transfusion transfusion NN cord-010092-uftc8inx 4304 6 practices practice NNS cord-010092-uftc8inx 4304 7 in in IN cord-010092-uftc8inx 4304 8 severely severely RB cord-010092-uftc8inx 4304 9 injured injure VBN cord-010092-uftc8inx 4304 10 trauma trauma NN cord-010092-uftc8inx 4304 11 patients patient NNS cord-010092-uftc8inx 4304 12 , , , cord-010092-uftc8inx 4304 13 admitted admit VBD cord-010092-uftc8inx 4304 14 to to IN cord-010092-uftc8inx 4304 15 the the DT cord-010092-uftc8inx 4304 16 red red JJ cord-010092-uftc8inx 4304 17 area area NN cord-010092-uftc8inx 4304 18 / / SYM cord-010092-uftc8inx 4304 19 resuscitation resuscitation NN cord-010092-uftc8inx 4304 20 bay bay NN cord-010092-uftc8inx 4304 21 after after IN cord-010092-uftc8inx 4304 22 initial initial JJ cord-010092-uftc8inx 4304 23 triage triage NN cord-010092-uftc8inx 4304 24 in in IN cord-010092-uftc8inx 4304 25 ED ED NNP cord-010092-uftc8inx 4304 26 Methods method NNS cord-010092-uftc8inx 4304 27 : : : cord-010092-uftc8inx 4304 28 This this DT cord-010092-uftc8inx 4304 29 prospective prospective JJ cord-010092-uftc8inx 4304 30 observational observational JJ cord-010092-uftc8inx 4304 31 study study NN cord-010092-uftc8inx 4304 32 was be VBD cord-010092-uftc8inx 4304 33 conducted conduct VBN cord-010092-uftc8inx 4304 34 over over IN cord-010092-uftc8inx 4304 35 a a DT cord-010092-uftc8inx 4304 36 period period NN cord-010092-uftc8inx 4304 37 of of IN cord-010092-uftc8inx 4304 38 1 1 CD cord-010092-uftc8inx 4304 39 year year NN cord-010092-uftc8inx 4304 40 starting start VBG cord-010092-uftc8inx 4304 41 from from IN cord-010092-uftc8inx 4304 42 June June NNP cord-010092-uftc8inx 4304 43 2017 2017 CD cord-010092-uftc8inx 4304 44 to to IN cord-010092-uftc8inx 4304 45 May May NNP cord-010092-uftc8inx 4304 46 2018 2018 CD cord-010092-uftc8inx 4304 47 at at IN cord-010092-uftc8inx 4304 48 the the DT cord-010092-uftc8inx 4304 49 Department Department NNP cord-010092-uftc8inx 4304 50 of of IN cord-010092-uftc8inx 4304 51 Transfusion Transfusion NNP cord-010092-uftc8inx 4304 52 medicine medicine NN cord-010092-uftc8inx 4304 53 in in IN cord-010092-uftc8inx 4304 54 collaboration collaboration NN cord-010092-uftc8inx 4304 55 with with IN cord-010092-uftc8inx 4304 56 Emergency Emergency NNP cord-010092-uftc8inx 4304 57 Department Department NNP cord-010092-uftc8inx 4304 58 at at IN cord-010092-uftc8inx 4304 59 JPNATC JPNATC NNP cord-010092-uftc8inx 4304 60 , , , cord-010092-uftc8inx 4304 61 AIIMS AIIMS NNP cord-010092-uftc8inx 4304 62 , , , cord-010092-uftc8inx 4304 63 New New NNP cord-010092-uftc8inx 4304 64 Delhi Delhi NNP cord-010092-uftc8inx 4304 65 . . . cord-010092-uftc8inx 4305 1 The the DT cord-010092-uftc8inx 4305 2 study study NN cord-010092-uftc8inx 4305 3 included include VBD cord-010092-uftc8inx 4305 4 severely severely RB cord-010092-uftc8inx 4305 5 injured injure VBN cord-010092-uftc8inx 4305 6 patients patient NNS cord-010092-uftc8inx 4305 7 ( ( -LRB- cord-010092-uftc8inx 4305 8 ISS ISS NNP cord-010092-uftc8inx 4305 9 ≥ ≥ NNP cord-010092-uftc8inx 4305 10 16 16 CD cord-010092-uftc8inx 4305 11 ) ) -RRB- cord-010092-uftc8inx 4305 12 that that WDT cord-010092-uftc8inx 4305 13 were be VBD cord-010092-uftc8inx 4305 14 admitted admit VBN cord-010092-uftc8inx 4305 15 within within IN cord-010092-uftc8inx 4305 16 24 24 CD cord-010092-uftc8inx 4305 17 h h NN cord-010092-uftc8inx 4305 18 to to IN cord-010092-uftc8inx 4305 19 the the DT cord-010092-uftc8inx 4305 20 red red JJ cord-010092-uftc8inx 4305 21 area area NN cord-010092-uftc8inx 4305 22 / / SYM cord-010092-uftc8inx 4305 23 resuscitation resuscitation NN cord-010092-uftc8inx 4305 24 bay bay NN cord-010092-uftc8inx 4305 25 after after IN cord-010092-uftc8inx 4305 26 triage triage NN cord-010092-uftc8inx 4305 27 . . . cord-010092-uftc8inx 4306 1 Data datum NNS cord-010092-uftc8inx 4306 2 collected collect VBN cord-010092-uftc8inx 4306 3 included include VBD cord-010092-uftc8inx 4306 4 the the DT cord-010092-uftc8inx 4306 5 demographics demographic NNS cord-010092-uftc8inx 4306 6 , , , cord-010092-uftc8inx 4306 7 injury injury NN cord-010092-uftc8inx 4306 8 , , , cord-010092-uftc8inx 4306 9 laboratory laboratory NN cord-010092-uftc8inx 4306 10 and and CC cord-010092-uftc8inx 4306 11 transfusion transfusion NN cord-010092-uftc8inx 4306 12 details detail NNS cord-010092-uftc8inx 4306 13 for for IN cord-010092-uftc8inx 4306 14 these these DT cord-010092-uftc8inx 4306 15 patients patient NNS cord-010092-uftc8inx 4306 16 Results result NNS cord-010092-uftc8inx 4306 17 : : : cord-010092-uftc8inx 4306 18 During during IN cord-010092-uftc8inx 4306 19 the the DT cord-010092-uftc8inx 4306 20 study study NN cord-010092-uftc8inx 4306 21 period period NN cord-010092-uftc8inx 4306 22 885 885 CD cord-010092-uftc8inx 4306 23 patients patient NNS cord-010092-uftc8inx 4306 24 ( ( -LRB- cord-010092-uftc8inx 4306 25 83.5 83.5 CD cord-010092-uftc8inx 4306 26 % % NN cord-010092-uftc8inx 4306 27 males male NNS cord-010092-uftc8inx 4306 28 ) ) -RRB- cord-010092-uftc8inx 4306 29 were be VBD cord-010092-uftc8inx 4306 30 enrolled enrol VBN cord-010092-uftc8inx 4306 31 . . . cord-010092-uftc8inx 4307 1 Mean mean JJ cord-010092-uftc8inx 4307 2 ISS ISS NNP cord-010092-uftc8inx 4307 3 scores score NNS cord-010092-uftc8inx 4307 4 was be VBD cord-010092-uftc8inx 4307 5 21.89 21.89 CD cord-010092-uftc8inx 4307 6 . . . cord-010092-uftc8inx 4308 1 Mean mean JJ cord-010092-uftc8inx 4308 2 time time NN cord-010092-uftc8inx 4308 3 to to IN cord-010092-uftc8inx 4308 4 hospital hospital NN cord-010092-uftc8inx 4308 5 admission admission NN cord-010092-uftc8inx 4308 6 after after IN cord-010092-uftc8inx 4308 7 injury injury NN cord-010092-uftc8inx 4308 8 was be VBD cord-010092-uftc8inx 4308 9 9:03 9:03 CD cord-010092-uftc8inx 4308 10 ( ( -LRB- cord-010092-uftc8inx 4308 11 IQR IQR NNP cord-010092-uftc8inx 4308 12 3.38 3.38 CD cord-010092-uftc8inx 4308 13 - - HYPH cord-010092-uftc8inx 4308 14 13:48 13:48 CD cord-010092-uftc8inx 4308 15 ) ) -RRB- cord-010092-uftc8inx 4308 16 hours hour NNS cord-010092-uftc8inx 4308 17 . . . cord-010092-uftc8inx 4309 1 Mean mean JJ cord-010092-uftc8inx 4309 2 time time NN cord-010092-uftc8inx 4309 3 to to IN cord-010092-uftc8inx 4309 4 first first JJ cord-010092-uftc8inx 4309 5 RBC RBC NNP cord-010092-uftc8inx 4309 6 transfusion transfusion NN cord-010092-uftc8inx 4309 7 following follow VBG cord-010092-uftc8inx 4309 8 admission admission NN cord-010092-uftc8inx 4309 9 was be VBD cord-010092-uftc8inx 4309 10 2:09 2:09 CD cord-010092-uftc8inx 4310 1 ( ( -LRB- cord-010092-uftc8inx 4310 2 IQR IQR NNP cord-010092-uftc8inx 4310 3 0:27 0:27 NNP cord-010092-uftc8inx 4310 4 - - HYPH cord-010092-uftc8inx 4310 5 2:45 2:45 CD cord-010092-uftc8inx 4310 6 ) ) -RRB- cord-010092-uftc8inx 4310 7 hours hour NNS cord-010092-uftc8inx 4310 8 . . . cord-010092-uftc8inx 4311 1 Approximately approximately RB cord-010092-uftc8inx 4311 2 49.3 49.3 CD cord-010092-uftc8inx 4311 3 % % NN cord-010092-uftc8inx 4311 4 ( ( -LRB- cord-010092-uftc8inx 4311 5 436 436 CD cord-010092-uftc8inx 4311 6 ) ) -RRB- cord-010092-uftc8inx 4311 7 patients patient NNS cord-010092-uftc8inx 4311 8 were be VBD cord-010092-uftc8inx 4311 9 in in IN cord-010092-uftc8inx 4311 10 shock shock NN cord-010092-uftc8inx 4311 11 ( ( -LRB- cord-010092-uftc8inx 4311 12 SBP SBP NNP cord-010092-uftc8inx 4311 13 < < XX cord-010092-uftc8inx 4311 14 90 90 CD cord-010092-uftc8inx 4311 15 mm mm CD cord-010092-uftc8inx 4311 16 Hg Hg NNP cord-010092-uftc8inx 4311 17 & & CC cord-010092-uftc8inx 4311 18 /or /or . cord-010092-uftc8inx 4311 19 pulse pulse NN cord-010092-uftc8inx 4311 20 rate rate NN cord-010092-uftc8inx 4311 21 > > XX cord-010092-uftc8inx 4311 22 110 110 CD cord-010092-uftc8inx 4311 23 / / SYM cord-010092-uftc8inx 4311 24 min min NN cord-010092-uftc8inx 4311 25 ) ) -RRB- cord-010092-uftc8inx 4311 26 . . . cord-010092-uftc8inx 4312 1 Whereas whereas IN cord-010092-uftc8inx 4312 2 , , , cord-010092-uftc8inx 4312 3 160 160 CD cord-010092-uftc8inx 4312 4 ( ( -LRB- cord-010092-uftc8inx 4312 5 18.1 18.1 CD cord-010092-uftc8inx 4312 6 % % NN cord-010092-uftc8inx 4312 7 ) ) -RRB- cord-010092-uftc8inx 4312 8 patients patient NNS cord-010092-uftc8inx 4312 9 were be VBD cord-010092-uftc8inx 4312 10 coagulopathic coagulopathic JJ cord-010092-uftc8inx 4312 11 ( ( -LRB- cord-010092-uftc8inx 4313 1 PT PT NNP cord-010092-uftc8inx 4313 2 ≥ ≥ CD cord-010092-uftc8inx 4313 3 1.5 1.5 CD cord-010092-uftc8inx 4313 4 times time NNS cord-010092-uftc8inx 4313 5 of of IN cord-010092-uftc8inx 4313 6 normal normal JJ cord-010092-uftc8inx 4313 7 ) ) -RRB- cord-010092-uftc8inx 4313 8 . . . cord-010092-uftc8inx 4314 1 During during IN cord-010092-uftc8inx 4314 2 initial initial JJ cord-010092-uftc8inx 4314 3 24 24 CD cord-010092-uftc8inx 4314 4 h h NN cord-010092-uftc8inx 4314 5 of of IN cord-010092-uftc8inx 4314 6 admission admission NN cord-010092-uftc8inx 4314 7 , , , cord-010092-uftc8inx 4314 8 these these DT cord-010092-uftc8inx 4314 9 patients patient NNS cord-010092-uftc8inx 4314 10 were be VBD cord-010092-uftc8inx 4314 11 transfused transfuse VBN cord-010092-uftc8inx 4314 12 with with IN cord-010092-uftc8inx 4314 13 2929 2929 CD cord-010092-uftc8inx 4314 14 ( ( -LRB- cord-010092-uftc8inx 4314 15 69.7 69.7 CD cord-010092-uftc8inx 4314 16 % % NN cord-010092-uftc8inx 4314 17 ) ) -RRB- cord-010092-uftc8inx 4315 1 RBC RBC NNP cord-010092-uftc8inx 4315 2 , , , cord-010092-uftc8inx 4315 3 1986 1986 CD cord-010092-uftc8inx 4315 4 ( ( -LRB- cord-010092-uftc8inx 4315 5 51.8 51.8 CD cord-010092-uftc8inx 4315 6 % % NN cord-010092-uftc8inx 4315 7 ) ) -RRB- cord-010092-uftc8inx 4315 8 FFP FFP NNP cord-010092-uftc8inx 4315 9 , , , cord-010092-uftc8inx 4315 10 2327 2327 CD cord-010092-uftc8inx 4315 11 ( ( -LRB- cord-010092-uftc8inx 4315 12 42.9 42.9 CD cord-010092-uftc8inx 4315 13 % % NN cord-010092-uftc8inx 4315 14 ) ) -RRB- cord-010092-uftc8inx 4316 1 RDP RDP NNP cord-010092-uftc8inx 4316 2 and and CC cord-010092-uftc8inx 4316 3 384 384 CD cord-010092-uftc8inx 4316 4 ( ( -LRB- cord-010092-uftc8inx 4316 5 81.5 81.5 CD cord-010092-uftc8inx 4316 6 % % NN cord-010092-uftc8inx 4316 7 ) ) -RRB- cord-010092-uftc8inx 4316 8 cryoprecipitate cryoprecipitate NNP cord-010092-uftc8inx 4316 9 of of IN cord-010092-uftc8inx 4316 10 total total JJ cord-010092-uftc8inx 4316 11 blood blood NN cord-010092-uftc8inx 4316 12 components component NNS cord-010092-uftc8inx 4316 13 utilized utilize VBN cord-010092-uftc8inx 4316 14 for for IN cord-010092-uftc8inx 4316 15 these these DT cord-010092-uftc8inx 4316 16 patients patient NNS cord-010092-uftc8inx 4316 17 . . . cord-010092-uftc8inx 4317 1 Massive massive JJ cord-010092-uftc8inx 4317 2 transfusion transfusion NN cord-010092-uftc8inx 4317 3 ( ( -LRB- cord-010092-uftc8inx 4317 4 defined define VBN cord-010092-uftc8inx 4317 5 as as IN cord-010092-uftc8inx 4317 6 transfusion transfusion NN cord-010092-uftc8inx 4317 7 of of IN cord-010092-uftc8inx 4317 8 ≥ ≥ CD cord-010092-uftc8inx 4317 9 5 5 CD cord-010092-uftc8inx 4317 10 units/4 units/4 NNP cord-010092-uftc8inx 4317 11 h h NN cord-010092-uftc8inx 4317 12 ) ) -RRB- cord-010092-uftc8inx 4317 13 was be VBD cord-010092-uftc8inx 4317 14 given give VBN cord-010092-uftc8inx 4317 15 to to IN cord-010092-uftc8inx 4317 16 190 190 CD cord-010092-uftc8inx 4317 17 ( ( -LRB- cord-010092-uftc8inx 4317 18 21.4 21.4 CD cord-010092-uftc8inx 4317 19 % % NN cord-010092-uftc8inx 4317 20 ) ) -RRB- cord-010092-uftc8inx 4317 21 patients patient NNS cord-010092-uftc8inx 4317 22 . . . cord-010092-uftc8inx 4318 1 Summary Summary NNP cord-010092-uftc8inx 4318 2 / / SYM cord-010092-uftc8inx 4318 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 4318 4 : : : cord-010092-uftc8inx 4319 1 Significant significant JJ cord-010092-uftc8inx 4319 2 quantity quantity NN cord-010092-uftc8inx 4319 3 of of IN cord-010092-uftc8inx 4319 4 blood blood NN cord-010092-uftc8inx 4319 5 components component NNS cord-010092-uftc8inx 4319 6 were be VBD cord-010092-uftc8inx 4319 7 required require VBN cord-010092-uftc8inx 4319 8 during during IN cord-010092-uftc8inx 4319 9 initial initial JJ cord-010092-uftc8inx 4319 10 resuscitation resuscitation NN cord-010092-uftc8inx 4319 11 in in IN cord-010092-uftc8inx 4319 12 severely severely RB cord-010092-uftc8inx 4319 13 injured injure VBN cord-010092-uftc8inx 4319 14 patients patient NNS cord-010092-uftc8inx 4319 15 . . . cord-010092-uftc8inx 4320 1 Pre pre JJ cord-010092-uftc8inx 4320 2 - - JJ cord-010092-uftc8inx 4320 3 hospital hospital JJ cord-010092-uftc8inx 4320 4 transfusion transfusion NN cord-010092-uftc8inx 4320 5 can can MD cord-010092-uftc8inx 4320 6 significantly significantly RB cord-010092-uftc8inx 4320 7 reduce reduce VB cord-010092-uftc8inx 4320 8 the the DT cord-010092-uftc8inx 4320 9 time time NN cord-010092-uftc8inx 4320 10 to to IN cord-010092-uftc8inx 4320 11 transfusion transfusion NN cord-010092-uftc8inx 4320 12 . . . cord-010092-uftc8inx 4321 1 Further further JJ cord-010092-uftc8inx 4321 2 studies study NNS cord-010092-uftc8inx 4321 3 are be VBP cord-010092-uftc8inx 4321 4 needed need VBN cord-010092-uftc8inx 4321 5 to to TO cord-010092-uftc8inx 4321 6 assess assess VB cord-010092-uftc8inx 4321 7 utility utility NN cord-010092-uftc8inx 4321 8 of of IN cord-010092-uftc8inx 4321 9 Pre pre JJ cord-010092-uftc8inx 4321 10 hospital hospital NN cord-010092-uftc8inx 4321 11 transfusion transfusion NN cord-010092-uftc8inx 4321 12 in in IN cord-010092-uftc8inx 4321 13 severely severely RB cord-010092-uftc8inx 4321 14 injured injure VBN cord-010092-uftc8inx 4321 15 patients patient NNS cord-010092-uftc8inx 4321 16 . . . cord-010092-uftc8inx 4322 1 Background background NN cord-010092-uftc8inx 4322 2 : : : cord-010092-uftc8inx 4323 1 Allogenic allogenic JJ cord-010092-uftc8inx 4323 2 stem stem NN cord-010092-uftc8inx 4323 3 cell cell NN cord-010092-uftc8inx 4323 4 transplantation transplantation NN cord-010092-uftc8inx 4323 5 recipients recipient NNS cord-010092-uftc8inx 4323 6 are be VBP cord-010092-uftc8inx 4323 7 known know VBN cord-010092-uftc8inx 4323 8 to to TO cord-010092-uftc8inx 4323 9 be be VB cord-010092-uftc8inx 4323 10 the the DT cord-010092-uftc8inx 4323 11 main main JJ cord-010092-uftc8inx 4323 12 consumers consumer NNS cord-010092-uftc8inx 4323 13 of of IN cord-010092-uftc8inx 4323 14 platelet platelet NN cord-010092-uftc8inx 4323 15 concentrates concentrate NNS cord-010092-uftc8inx 4323 16 ( ( -LRB- cord-010092-uftc8inx 4323 17 PC pc NN cord-010092-uftc8inx 4323 18 ) ) -RRB- cord-010092-uftc8inx 4323 19 . . . cord-010092-uftc8inx 4324 1 The the DT cord-010092-uftc8inx 4324 2 Geneva Geneva NNP cord-010092-uftc8inx 4324 3 university university NN cord-010092-uftc8inx 4324 4 hospital hospital NN cord-010092-uftc8inx 4324 5 is be VBZ cord-010092-uftc8inx 4324 6 one one CD cord-010092-uftc8inx 4324 7 of of IN cord-010092-uftc8inx 4324 8 the the DT cord-010092-uftc8inx 4324 9 three three CD cord-010092-uftc8inx 4324 10 allogeneic allogeneic NN cord-010092-uftc8inx 4324 11 hematopoietic hematopoietic JJ cord-010092-uftc8inx 4324 12 stem stem NN cord-010092-uftc8inx 4324 13 cell cell NN cord-010092-uftc8inx 4324 14 transplantation transplantation NN cord-010092-uftc8inx 4324 15 ( ( -LRB- cord-010092-uftc8inx 4324 16 HSCT HSCT NNP cord-010092-uftc8inx 4324 17 ) ) -RRB- cord-010092-uftc8inx 4324 18 centers center NNS cord-010092-uftc8inx 4324 19 in in IN cord-010092-uftc8inx 4324 20 Switzerland Switzerland NNP cord-010092-uftc8inx 4324 21 . . . cord-010092-uftc8inx 4325 1 Since since IN cord-010092-uftc8inx 4325 2 the the DT cord-010092-uftc8inx 4325 3 blood blood NN cord-010092-uftc8inx 4325 4 center center NN cord-010092-uftc8inx 4325 5 is be VBZ cord-010092-uftc8inx 4325 6 also also RB cord-010092-uftc8inx 4325 7 part part NN cord-010092-uftc8inx 4325 8 of of IN cord-010092-uftc8inx 4325 9 the the DT cord-010092-uftc8inx 4325 10 hospital hospital NN cord-010092-uftc8inx 4325 11 , , , cord-010092-uftc8inx 4325 12 data datum NNS cord-010092-uftc8inx 4325 13 of of IN cord-010092-uftc8inx 4325 14 PC pc NN cord-010092-uftc8inx 4325 15 consumption consumption NN cord-010092-uftc8inx 4325 16 are be VBP cord-010092-uftc8inx 4325 17 easily easily RB cord-010092-uftc8inx 4325 18 available available JJ cord-010092-uftc8inx 4325 19 . . . cord-010092-uftc8inx 4326 1 As as IN cord-010092-uftc8inx 4326 2 needs need NNS cord-010092-uftc8inx 4326 3 rose rise VBD cord-010092-uftc8inx 4326 4 steadily steadily RB cord-010092-uftc8inx 4326 5 since since IN cord-010092-uftc8inx 4326 6 several several JJ cord-010092-uftc8inx 4326 7 years year NNS cord-010092-uftc8inx 4326 8 , , , cord-010092-uftc8inx 4326 9 with with IN cord-010092-uftc8inx 4326 10 an an DT cord-010092-uftc8inx 4326 11 average average JJ cord-010092-uftc8inx 4326 12 increase increase NN cord-010092-uftc8inx 4326 13 of of IN cord-010092-uftc8inx 4326 14 9 9 CD cord-010092-uftc8inx 4326 15 % % NN cord-010092-uftc8inx 4326 16 per per IN cord-010092-uftc8inx 4326 17 year year NN cord-010092-uftc8inx 4326 18 , , , cord-010092-uftc8inx 4326 19 PC pc NN cord-010092-uftc8inx 4326 20 supply supply NN cord-010092-uftc8inx 4326 21 is be VBZ cord-010092-uftc8inx 4326 22 a a DT cord-010092-uftc8inx 4326 23 serious serious JJ cord-010092-uftc8inx 4326 24 concern concern NN cord-010092-uftc8inx 4326 25 for for IN cord-010092-uftc8inx 4326 26 our -PRON- PRP$ cord-010092-uftc8inx 4326 27 center center NN cord-010092-uftc8inx 4326 28 . . . cord-010092-uftc8inx 4327 1 Aims aim VBZ cord-010092-uftc8inx 4327 2 : : : cord-010092-uftc8inx 4328 1 In in IN cord-010092-uftc8inx 4328 2 this this DT cord-010092-uftc8inx 4328 3 study study NN cord-010092-uftc8inx 4328 4 we -PRON- PRP cord-010092-uftc8inx 4328 5 tried try VBD cord-010092-uftc8inx 4328 6 to to TO cord-010092-uftc8inx 4328 7 evaluate evaluate VB cord-010092-uftc8inx 4328 8 if if IN cord-010092-uftc8inx 4328 9 any any DT cord-010092-uftc8inx 4328 10 pre pre JJ cord-010092-uftc8inx 4328 11 - - JJ cord-010092-uftc8inx 4328 12 transplant transplant NN cord-010092-uftc8inx 4328 13 indicator indicator NN cord-010092-uftc8inx 4328 14 could could MD cord-010092-uftc8inx 4328 15 help help VB cord-010092-uftc8inx 4328 16 to to TO cord-010092-uftc8inx 4328 17 forecast forecast VB cord-010092-uftc8inx 4328 18 the the DT cord-010092-uftc8inx 4328 19 number number NN cord-010092-uftc8inx 4328 20 of of IN cord-010092-uftc8inx 4328 21 PC pc NN cord-010092-uftc8inx 4328 22 needed need VBN cord-010092-uftc8inx 4328 23 after after IN cord-010092-uftc8inx 4328 24 an an DT cord-010092-uftc8inx 4328 25 allogeneic allogeneic JJ cord-010092-uftc8inx 4328 26 hematopoietic hematopoietic JJ cord-010092-uftc8inx 4328 27 stem stem NN cord-010092-uftc8inx 4328 28 cell cell NN cord-010092-uftc8inx 4328 29 transplantation transplantation NN cord-010092-uftc8inx 4328 30 . . . cord-010092-uftc8inx 4329 1 Methods method NNS cord-010092-uftc8inx 4329 2 : : : cord-010092-uftc8inx 4329 3 This this DT cord-010092-uftc8inx 4329 4 observational observational JJ cord-010092-uftc8inx 4329 5 retrospective retrospective JJ cord-010092-uftc8inx 4329 6 study study NN cord-010092-uftc8inx 4329 7 was be VBD cord-010092-uftc8inx 4329 8 conducted conduct VBN cord-010092-uftc8inx 4329 9 in in IN cord-010092-uftc8inx 4329 10 Geneva Geneva NNP cord-010092-uftc8inx 4329 11 hospital hospital NN cord-010092-uftc8inx 4329 12 on on IN cord-010092-uftc8inx 4329 13 78 78 CD cord-010092-uftc8inx 4329 14 patients patient NNS cord-010092-uftc8inx 4329 15 suffering suffer VBG cord-010092-uftc8inx 4329 16 from from IN cord-010092-uftc8inx 4329 17 various various JJ cord-010092-uftc8inx 4329 18 inherited inherit VBN cord-010092-uftc8inx 4329 19 or or CC cord-010092-uftc8inx 4329 20 acquired acquire VBN cord-010092-uftc8inx 4329 21 disorders disorder NNS cord-010092-uftc8inx 4329 22 of of IN cord-010092-uftc8inx 4329 23 the the DT cord-010092-uftc8inx 4329 24 hematopoietic hematopoietic JJ cord-010092-uftc8inx 4329 25 system system NN cord-010092-uftc8inx 4329 26 who who WP cord-010092-uftc8inx 4329 27 were be VBD cord-010092-uftc8inx 4329 28 treated treat VBN cord-010092-uftc8inx 4329 29 by by IN cord-010092-uftc8inx 4329 30 HSCT HSCT NNP cord-010092-uftc8inx 4329 31 in in IN cord-010092-uftc8inx 4329 32 2016 2016 CD cord-010092-uftc8inx 4329 33 . . . cord-010092-uftc8inx 4330 1 PC pc NN cord-010092-uftc8inx 4330 2 consumption consumption NN cord-010092-uftc8inx 4330 3 was be VBD cord-010092-uftc8inx 4330 4 examined examine VBN cord-010092-uftc8inx 4330 5 from from IN cord-010092-uftc8inx 4330 6 January January NNP cord-010092-uftc8inx 4330 7 2016 2016 CD cord-010092-uftc8inx 4330 8 to to IN cord-010092-uftc8inx 4330 9 December December NNP cord-010092-uftc8inx 4330 10 2018 2018 CD cord-010092-uftc8inx 4330 11 . . . cord-010092-uftc8inx 4331 1 The the DT cord-010092-uftc8inx 4331 2 five five CD cord-010092-uftc8inx 4331 3 indicators indicator NNS cord-010092-uftc8inx 4331 4 were be VBD cord-010092-uftc8inx 4331 5 : : : cord-010092-uftc8inx 4331 6 gender gender NN cord-010092-uftc8inx 4331 7 , , , cord-010092-uftc8inx 4331 8 stem stem NN cord-010092-uftc8inx 4331 9 cell cell NN cord-010092-uftc8inx 4331 10 source source NN cord-010092-uftc8inx 4331 11 ( ( -LRB- cord-010092-uftc8inx 4331 12 Bone bone NN cord-010092-uftc8inx 4331 13 Marrow marrow NN cord-010092-uftc8inx 4331 14 ( ( -LRB- cord-010092-uftc8inx 4331 15 BM BM NNP cord-010092-uftc8inx 4331 16 ) ) -RRB- cord-010092-uftc8inx 4331 17 vs vs IN cord-010092-uftc8inx 4331 18 Peripheral Peripheral NNP cord-010092-uftc8inx 4331 19 Blood Blood NNP cord-010092-uftc8inx 4331 20 Stem Stem NNP cord-010092-uftc8inx 4331 21 Cell cell NN cord-010092-uftc8inx 4331 22 ( ( -LRB- cord-010092-uftc8inx 4331 23 PBSC PBSC NNP cord-010092-uftc8inx 4331 24 ) ) -RRB- cord-010092-uftc8inx 4331 25 ) ) -RRB- cord-010092-uftc8inx 4331 26 , , , cord-010092-uftc8inx 4331 27 donor donor NN cord-010092-uftc8inx 4331 28 type type NN cord-010092-uftc8inx 4331 29 ( ( -LRB- cord-010092-uftc8inx 4331 30 HLA HLA NNP cord-010092-uftc8inx 4331 31 matched match VBD cord-010092-uftc8inx 4331 32 ( ( -LRB- cord-010092-uftc8inx 4331 33 10 10 CD cord-010092-uftc8inx 4331 34 - - SYM cord-010092-uftc8inx 4331 35 8/10 8/10 CD cord-010092-uftc8inx 4331 36 ) ) -RRB- cord-010092-uftc8inx 4331 37 vs vs IN cord-010092-uftc8inx 4331 38 haploidentical haploidentical NNP cord-010092-uftc8inx 4331 39 ) ) -RRB- cord-010092-uftc8inx 4331 40 , , , cord-010092-uftc8inx 4331 41 conditioning conditioning NN cord-010092-uftc8inx 4331 42 regimen regimen NN cord-010092-uftc8inx 4331 43 ( ( -LRB- cord-010092-uftc8inx 4331 44 standard standard NN cord-010092-uftc8inx 4331 45 vs vs IN cord-010092-uftc8inx 4331 46 reduced reduced JJ cord-010092-uftc8inx 4331 47 intensity intensity NN cord-010092-uftc8inx 4331 48 ) ) -RRB- cord-010092-uftc8inx 4331 49 , , , cord-010092-uftc8inx 4331 50 and and CC cord-010092-uftc8inx 4331 51 CMV CMV NNP cord-010092-uftc8inx 4331 52 serology serology NN cord-010092-uftc8inx 4331 53 of of IN cord-010092-uftc8inx 4331 54 the the DT cord-010092-uftc8inx 4331 55 recipient recipient NN cord-010092-uftc8inx 4331 56 . . . cord-010092-uftc8inx 4332 1 Results result NNS cord-010092-uftc8inx 4332 2 : : : cord-010092-uftc8inx 4333 1 Data datum NNS cord-010092-uftc8inx 4333 2 for for IN cord-010092-uftc8inx 4333 3 a a DT cord-010092-uftc8inx 4333 4 total total NN cord-010092-uftc8inx 4333 5 of of IN cord-010092-uftc8inx 4333 6 78 78 CD cord-010092-uftc8inx 4333 7 patients patient NNS cord-010092-uftc8inx 4333 8 aged age VBN cord-010092-uftc8inx 4333 9 from from IN cord-010092-uftc8inx 4333 10 3 3 CD cord-010092-uftc8inx 4333 11 to to IN cord-010092-uftc8inx 4333 12 74 74 CD cord-010092-uftc8inx 4333 13 years year NNS cord-010092-uftc8inx 4333 14 were be VBD cord-010092-uftc8inx 4333 15 analyzed analyze VBN cord-010092-uftc8inx 4333 16 ; ; : cord-010092-uftc8inx 4333 17 48 48 CD cord-010092-uftc8inx 4333 18 ( ( -LRB- cord-010092-uftc8inx 4333 19 62 62 CD cord-010092-uftc8inx 4333 20 % % NN cord-010092-uftc8inx 4333 21 ) ) -RRB- cord-010092-uftc8inx 4333 22 were be VBD cord-010092-uftc8inx 4333 23 male male JJ cord-010092-uftc8inx 4333 24 and and CC cord-010092-uftc8inx 4333 25 30 30 CD cord-010092-uftc8inx 4333 26 ( ( -LRB- cord-010092-uftc8inx 4333 27 38 38 CD cord-010092-uftc8inx 4333 28 % % NN cord-010092-uftc8inx 4333 29 ) ) -RRB- cord-010092-uftc8inx 4333 30 female female JJ cord-010092-uftc8inx 4333 31 ; ; : cord-010092-uftc8inx 4333 32 35 35 CD cord-010092-uftc8inx 4333 33 ( ( -LRB- cord-010092-uftc8inx 4333 34 45 45 CD cord-010092-uftc8inx 4333 35 % % NN cord-010092-uftc8inx 4333 36 ) ) -RRB- cord-010092-uftc8inx 4333 37 were be VBD cord-010092-uftc8inx 4333 38 CMV CMV NNP cord-010092-uftc8inx 4333 39 - - HYPH cord-010092-uftc8inx 4333 40 negative negative JJ cord-010092-uftc8inx 4333 41 and and CC cord-010092-uftc8inx 4333 42 43 43 CD cord-010092-uftc8inx 4333 43 ( ( -LRB- cord-010092-uftc8inx 4333 44 55 55 CD cord-010092-uftc8inx 4333 45 % % NN cord-010092-uftc8inx 4333 46 ) ) -RRB- cord-010092-uftc8inx 4333 47 were be VBD cord-010092-uftc8inx 4333 48 CMV CMV NNP cord-010092-uftc8inx 4333 49 - - HYPH cord-010092-uftc8inx 4333 50 positive positive JJ cord-010092-uftc8inx 4333 51 . . . cord-010092-uftc8inx 4334 1 Out out IN cord-010092-uftc8inx 4334 2 of of IN cord-010092-uftc8inx 4334 3 a a DT cord-010092-uftc8inx 4334 4 total total NN cord-010092-uftc8inx 4334 5 of of IN cord-010092-uftc8inx 4334 6 78 78 CD cord-010092-uftc8inx 4334 7 transplants transplant NNS cord-010092-uftc8inx 4334 8 , , , cord-010092-uftc8inx 4334 9 14 14 CD cord-010092-uftc8inx 4334 10 ( ( -LRB- cord-010092-uftc8inx 4334 11 17.9 17.9 CD cord-010092-uftc8inx 4334 12 % % NN cord-010092-uftc8inx 4334 13 ) ) -RRB- cord-010092-uftc8inx 4334 14 were be VBD cord-010092-uftc8inx 4334 15 haploidentical haploidentical JJ cord-010092-uftc8inx 4334 16 and and CC cord-010092-uftc8inx 4334 17 64 64 CD cord-010092-uftc8inx 4334 18 ( ( -LRB- cord-010092-uftc8inx 4334 19 82.1 82.1 CD cord-010092-uftc8inx 4334 20 % % NN cord-010092-uftc8inx 4334 21 ) ) -RRB- cord-010092-uftc8inx 4335 1 HLA HLA NNP cord-010092-uftc8inx 4335 2 - - HYPH cord-010092-uftc8inx 4335 3 matched match VBN cord-010092-uftc8inx 4335 4 . . . cord-010092-uftc8inx 4336 1 According accord VBG cord-010092-uftc8inx 4336 2 to to IN cord-010092-uftc8inx 4336 3 the the DT cord-010092-uftc8inx 4336 4 stem stem NN cord-010092-uftc8inx 4336 5 cell cell NN cord-010092-uftc8inx 4336 6 source source NN cord-010092-uftc8inx 4336 7 , , , cord-010092-uftc8inx 4336 8 BM BM NNP cord-010092-uftc8inx 4336 9 was be VBD cord-010092-uftc8inx 4336 10 transplanted transplant VBN cord-010092-uftc8inx 4336 11 in in IN cord-010092-uftc8inx 4336 12 22 22 CD cord-010092-uftc8inx 4336 13 cases case NNS cord-010092-uftc8inx 4336 14 ( ( -LRB- cord-010092-uftc8inx 4336 15 28.2 28.2 CD cord-010092-uftc8inx 4336 16 % % NN cord-010092-uftc8inx 4336 17 ) ) -RRB- cord-010092-uftc8inx 4336 18 , , , cord-010092-uftc8inx 4336 19 and and CC cord-010092-uftc8inx 4336 20 PBSC PBSC NNP cord-010092-uftc8inx 4336 21 in in IN cord-010092-uftc8inx 4336 22 56 56 CD cord-010092-uftc8inx 4336 23 cases case NNS cord-010092-uftc8inx 4336 24 ( ( -LRB- cord-010092-uftc8inx 4336 25 71.8 71.8 CD cord-010092-uftc8inx 4336 26 % % NN cord-010092-uftc8inx 4336 27 ) ) -RRB- cord-010092-uftc8inx 4336 28 . . . cord-010092-uftc8inx 4337 1 Two two CD cord-010092-uftc8inx 4337 2 patients patient NNS cord-010092-uftc8inx 4337 3 also also RB cord-010092-uftc8inx 4337 4 received receive VBD cord-010092-uftc8inx 4337 5 a a DT cord-010092-uftc8inx 4337 6 CD34 CD34 NNP cord-010092-uftc8inx 4337 7 + + CC cord-010092-uftc8inx 4337 8 stem stem NN cord-010092-uftc8inx 4337 9 cell cell NN cord-010092-uftc8inx 4337 10 boost boost NN cord-010092-uftc8inx 4337 11 . . . cord-010092-uftc8inx 4338 1 Our -PRON- PRP$ cord-010092-uftc8inx 4338 2 analysis analysis NN cord-010092-uftc8inx 4338 3 showed show VBD cord-010092-uftc8inx 4338 4 that that IN cord-010092-uftc8inx 4338 5 , , , cord-010092-uftc8inx 4338 6 with with IN cord-010092-uftc8inx 4338 7 a a DT cord-010092-uftc8inx 4338 8 mean mean JJ cord-010092-uftc8inx 4338 9 follow follow NN cord-010092-uftc8inx 4338 10 - - HYPH cord-010092-uftc8inx 4338 11 up up NN cord-010092-uftc8inx 4338 12 of of IN cord-010092-uftc8inx 4338 13 652 652 CD cord-010092-uftc8inx 4338 14 days day NNS cord-010092-uftc8inx 4338 15 , , , cord-010092-uftc8inx 4338 16 the the DT cord-010092-uftc8inx 4338 17 number number NN cord-010092-uftc8inx 4338 18 of of IN cord-010092-uftc8inx 4338 19 PC pc NN cord-010092-uftc8inx 4338 20 transfused transfuse VBN cord-010092-uftc8inx 4338 21 to to IN cord-010092-uftc8inx 4338 22 our -PRON- PRP$ cord-010092-uftc8inx 4338 23 patients patient NNS cord-010092-uftc8inx 4338 24 treated treat VBN cord-010092-uftc8inx 4338 25 by by IN cord-010092-uftc8inx 4338 26 HSCT HSCT NNP cord-010092-uftc8inx 4338 27 ranged range VBD cord-010092-uftc8inx 4338 28 from from IN cord-010092-uftc8inx 4338 29 0 0 CD cord-010092-uftc8inx 4338 30 to to IN cord-010092-uftc8inx 4338 31 383 383 CD cord-010092-uftc8inx 4338 32 units unit NNS cord-010092-uftc8inx 4338 33 , , , cord-010092-uftc8inx 4338 34 with with IN cord-010092-uftc8inx 4338 35 an an DT cord-010092-uftc8inx 4338 36 average average NN cord-010092-uftc8inx 4338 37 of of IN cord-010092-uftc8inx 4338 38 37 37 CD cord-010092-uftc8inx 4338 39 and and CC cord-010092-uftc8inx 4338 40 a a DT cord-010092-uftc8inx 4338 41 median median NN cord-010092-uftc8inx 4338 42 of of IN cord-010092-uftc8inx 4338 43 15 15 CD cord-010092-uftc8inx 4338 44 , , , cord-010092-uftc8inx 4338 45 illustrating illustrate VBG cord-010092-uftc8inx 4338 46 a a DT cord-010092-uftc8inx 4338 47 high high JJ cord-010092-uftc8inx 4338 48 variability variability NN cord-010092-uftc8inx 4338 49 . . . cord-010092-uftc8inx 4339 1 The the DT cord-010092-uftc8inx 4339 2 results result NNS cord-010092-uftc8inx 4339 3 indicated indicate VBD cord-010092-uftc8inx 4339 4 that that IN cord-010092-uftc8inx 4339 5 gender gender NN cord-010092-uftc8inx 4339 6 , , , cord-010092-uftc8inx 4339 7 stem stem NN cord-010092-uftc8inx 4339 8 cell cell NN cord-010092-uftc8inx 4339 9 source source NN cord-010092-uftc8inx 4339 10 ( ( -LRB- cord-010092-uftc8inx 4339 11 BM BM NNP cord-010092-uftc8inx 4339 12 vs vs IN cord-010092-uftc8inx 4339 13 PBSC PBSC NNP cord-010092-uftc8inx 4339 14 ) ) -RRB- cord-010092-uftc8inx 4339 15 , , , cord-010092-uftc8inx 4339 16 conditioning conditioning NN cord-010092-uftc8inx 4339 17 regimen regimen NN cord-010092-uftc8inx 4339 18 ( ( -LRB- cord-010092-uftc8inx 4339 19 standard standard NN cord-010092-uftc8inx 4339 20 vs vs IN cord-010092-uftc8inx 4339 21 reduced reduced JJ cord-010092-uftc8inx 4339 22 intensity intensity NN cord-010092-uftc8inx 4339 23 ) ) -RRB- cord-010092-uftc8inx 4339 24 , , , cord-010092-uftc8inx 4339 25 and and CC cord-010092-uftc8inx 4339 26 CMV CMV NNP cord-010092-uftc8inx 4339 27 serology serology NN cord-010092-uftc8inx 4339 28 of of IN cord-010092-uftc8inx 4339 29 the the DT cord-010092-uftc8inx 4339 30 recipient recipient NN cord-010092-uftc8inx 4339 31 do do VBP cord-010092-uftc8inx 4339 32 not not RB cord-010092-uftc8inx 4339 33 have have VB cord-010092-uftc8inx 4339 34 any any DT cord-010092-uftc8inx 4339 35 statistical statistical JJ cord-010092-uftc8inx 4339 36 impact impact NN cord-010092-uftc8inx 4339 37 on on IN cord-010092-uftc8inx 4339 38 platelet platelet NN cord-010092-uftc8inx 4339 39 consumption consumption NN cord-010092-uftc8inx 4339 40 . . . cord-010092-uftc8inx 4340 1 However however RB cord-010092-uftc8inx 4340 2 , , , cord-010092-uftc8inx 4340 3 we -PRON- PRP cord-010092-uftc8inx 4340 4 observed observe VBD cord-010092-uftc8inx 4340 5 a a DT cord-010092-uftc8inx 4340 6 tendency tendency NN cord-010092-uftc8inx 4340 7 of of IN cord-010092-uftc8inx 4340 8 an an DT cord-010092-uftc8inx 4340 9 increased increase VBN cord-010092-uftc8inx 4340 10 need need NN cord-010092-uftc8inx 4340 11 for for IN cord-010092-uftc8inx 4340 12 platelet platelet NN cord-010092-uftc8inx 4340 13 transfusion transfusion NN cord-010092-uftc8inx 4340 14 when when WRB cord-010092-uftc8inx 4340 15 patients patient NNS cord-010092-uftc8inx 4340 16 were be VBD cord-010092-uftc8inx 4340 17 CMV CMV NNP cord-010092-uftc8inx 4340 18 positive positive JJ cord-010092-uftc8inx 4340 19 . . . cord-010092-uftc8inx 4341 1 Our -PRON- PRP$ cord-010092-uftc8inx 4341 2 results result NNS cord-010092-uftc8inx 4341 3 also also RB cord-010092-uftc8inx 4341 4 showed show VBD cord-010092-uftc8inx 4341 5 a a DT cord-010092-uftc8inx 4341 6 statistically statistically RB cord-010092-uftc8inx 4341 7 significant significant JJ cord-010092-uftc8inx 4341 8 ( ( -LRB- cord-010092-uftc8inx 4341 9 P p NN cord-010092-uftc8inx 4341 10 = = SYM cord-010092-uftc8inx 4341 11 0.034 0.034 CD cord-010092-uftc8inx 4341 12 ) ) -RRB- cord-010092-uftc8inx 4342 1 higher high JJR cord-010092-uftc8inx 4342 2 number number NN cord-010092-uftc8inx 4342 3 of of IN cord-010092-uftc8inx 4342 4 PC pc NN cord-010092-uftc8inx 4342 5 transfused transfuse VBN cord-010092-uftc8inx 4342 6 for for IN cord-010092-uftc8inx 4342 7 patients patient NNS cord-010092-uftc8inx 4342 8 treated treat VBN cord-010092-uftc8inx 4342 9 with with IN cord-010092-uftc8inx 4342 10 a a DT cord-010092-uftc8inx 4342 11 haploidentical haploidentical JJ cord-010092-uftc8inx 4342 12 ( ( -LRB- cord-010092-uftc8inx 4342 13 89 89 CD cord-010092-uftc8inx 4342 14 ) ) -RRB- cord-010092-uftc8inx 4342 15 versus versus IN cord-010092-uftc8inx 4342 16 HLA HLA NNP cord-010092-uftc8inx 4342 17 - - HYPH cord-010092-uftc8inx 4342 18 matched match VBN cord-010092-uftc8inx 4342 19 ( ( -LRB- cord-010092-uftc8inx 4342 20 26 26 CD cord-010092-uftc8inx 4342 21 ) ) -RRB- cord-010092-uftc8inx 4342 22 transplant transplant NN cord-010092-uftc8inx 4342 23 . . . cord-010092-uftc8inx 4343 1 Summary Summary NNP cord-010092-uftc8inx 4343 2 / / SYM cord-010092-uftc8inx 4343 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 4343 4 : : : cord-010092-uftc8inx 4344 1 This this DT cord-010092-uftc8inx 4344 2 study study NN cord-010092-uftc8inx 4344 3 points point VBZ cord-010092-uftc8inx 4344 4 out out RP cord-010092-uftc8inx 4344 5 the the DT cord-010092-uftc8inx 4344 6 high high JJ cord-010092-uftc8inx 4344 7 variability variability NN cord-010092-uftc8inx 4344 8 of of IN cord-010092-uftc8inx 4344 9 platelet platelet NN cord-010092-uftc8inx 4344 10 consumption consumption NN cord-010092-uftc8inx 4344 11 after after IN cord-010092-uftc8inx 4344 12 HSCT HSCT NNP cord-010092-uftc8inx 4344 13 , , , cord-010092-uftc8inx 4344 14 which which WDT cord-010092-uftc8inx 4344 15 limits limit VBZ cord-010092-uftc8inx 4344 16 the the DT cord-010092-uftc8inx 4344 17 forecast forecast NN cord-010092-uftc8inx 4344 18 of of IN cord-010092-uftc8inx 4344 19 platelet platelet NN cord-010092-uftc8inx 4344 20 production production NN cord-010092-uftc8inx 4344 21 needed need VBN cord-010092-uftc8inx 4344 22 to to TO cord-010092-uftc8inx 4344 23 support support VB cord-010092-uftc8inx 4344 24 allogeneic allogeneic NN cord-010092-uftc8inx 4344 25 HSCT HSCT NNP cord-010092-uftc8inx 4344 26 recipients recipient NNS cord-010092-uftc8inx 4344 27 . . . cord-010092-uftc8inx 4345 1 A a DT cord-010092-uftc8inx 4345 2 larger large JJR cord-010092-uftc8inx 4345 3 cohort cohort NN cord-010092-uftc8inx 4345 4 would would MD cord-010092-uftc8inx 4345 5 be be VB cord-010092-uftc8inx 4345 6 required require VBN cord-010092-uftc8inx 4345 7 to to TO cord-010092-uftc8inx 4345 8 confirm confirm VB cord-010092-uftc8inx 4345 9 a a DT cord-010092-uftc8inx 4345 10 potentially potentially RB cord-010092-uftc8inx 4345 11 higher high JJR cord-010092-uftc8inx 4345 12 platelet platelet NN cord-010092-uftc8inx 4345 13 consumption consumption NN cord-010092-uftc8inx 4345 14 in in IN cord-010092-uftc8inx 4345 15 CMV CMV NNP cord-010092-uftc8inx 4345 16 positive positive JJ cord-010092-uftc8inx 4345 17 patients patient NNS cord-010092-uftc8inx 4345 18 , , , cord-010092-uftc8inx 4345 19 and and CC cord-010092-uftc8inx 4345 20 to to TO cord-010092-uftc8inx 4345 21 consolidate consolidate VB cord-010092-uftc8inx 4345 22 our -PRON- PRP$ cord-010092-uftc8inx 4345 23 results result NNS cord-010092-uftc8inx 4345 24 showing show VBG cord-010092-uftc8inx 4345 25 a a DT cord-010092-uftc8inx 4345 26 higher high JJR cord-010092-uftc8inx 4345 27 PC pc NN cord-010092-uftc8inx 4345 28 consumption consumption NN cord-010092-uftc8inx 4345 29 for for IN cord-010092-uftc8inx 4345 30 patients patient NNS cord-010092-uftc8inx 4345 31 treated treat VBN cord-010092-uftc8inx 4345 32 with with IN cord-010092-uftc8inx 4345 33 haploidentical haploidentical JJ cord-010092-uftc8inx 4345 34 transplant transplant NN cord-010092-uftc8inx 4345 35 . . . cord-010092-uftc8inx 4346 1 Abstract Abstract NNP cord-010092-uftc8inx 4346 2 withdrawn withdraw VBN cord-010092-uftc8inx 4346 3 . . . cord-010092-uftc8inx 4347 1 Background background NN cord-010092-uftc8inx 4347 2 : : : cord-010092-uftc8inx 4348 1 Historically historically RB cord-010092-uftc8inx 4348 2 at at IN cord-010092-uftc8inx 4348 3 our -PRON- PRP$ cord-010092-uftc8inx 4348 4 institution institution NN cord-010092-uftc8inx 4348 5 , , , cord-010092-uftc8inx 4348 6 a a DT cord-010092-uftc8inx 4348 7 minimum minimum NN cord-010092-uftc8inx 4348 8 of of IN cord-010092-uftc8inx 4348 9 four four CD cord-010092-uftc8inx 4348 10 red red JJ cord-010092-uftc8inx 4348 11 blood blood NN cord-010092-uftc8inx 4348 12 cell cell NN cord-010092-uftc8inx 4348 13 ( ( -LRB- cord-010092-uftc8inx 4348 14 RBC RBC NNP cord-010092-uftc8inx 4348 15 ) ) -RRB- cord-010092-uftc8inx 4348 16 units unit NNS cord-010092-uftc8inx 4348 17 were be VBD cord-010092-uftc8inx 4348 18 crossmatched crossmatche VBN cord-010092-uftc8inx 4348 19 for for IN cord-010092-uftc8inx 4348 20 all all DT cord-010092-uftc8inx 4348 21 cardiac cardiac JJ cord-010092-uftc8inx 4348 22 surgery surgery NN cord-010092-uftc8inx 4348 23 cases case NNS cord-010092-uftc8inx 4348 24 regardless regardless RB cord-010092-uftc8inx 4348 25 of of IN cord-010092-uftc8inx 4348 26 surgical surgical JJ cord-010092-uftc8inx 4348 27 case case NN cord-010092-uftc8inx 4348 28 - - HYPH cord-010092-uftc8inx 4348 29 type type NN cord-010092-uftc8inx 4348 30 or or CC cord-010092-uftc8inx 4348 31 patient patient JJ cord-010092-uftc8inx 4348 32 characteristics characteristic NNS cord-010092-uftc8inx 4348 33 . . . cord-010092-uftc8inx 4349 1 Two two CD cord-010092-uftc8inx 4349 2 RBC RBC NNP cord-010092-uftc8inx 4349 3 units unit NNS cord-010092-uftc8inx 4349 4 were be VBD cord-010092-uftc8inx 4349 5 packed pack VBN cord-010092-uftc8inx 4349 6 in in IN cord-010092-uftc8inx 4349 7 validated validate VBN cord-010092-uftc8inx 4349 8 blood blood NN cord-010092-uftc8inx 4349 9 product product NN cord-010092-uftc8inx 4349 10 coolers cooler NNS cord-010092-uftc8inx 4349 11 and and CC cord-010092-uftc8inx 4349 12 brought bring VBN cord-010092-uftc8inx 4349 13 to to IN cord-010092-uftc8inx 4349 14 the the DT cord-010092-uftc8inx 4349 15 operating operating NN cord-010092-uftc8inx 4349 16 room room NN cord-010092-uftc8inx 4349 17 ( ( -LRB- cord-010092-uftc8inx 4349 18 OR or CC cord-010092-uftc8inx 4349 19 ) ) -RRB- cord-010092-uftc8inx 4349 20 ; ; : cord-010092-uftc8inx 4349 21 the the DT cord-010092-uftc8inx 4349 22 balance balance NN cord-010092-uftc8inx 4349 23 of of IN cord-010092-uftc8inx 4349 24 crossmatched crossmatched JJ cord-010092-uftc8inx 4349 25 units unit NNS cord-010092-uftc8inx 4349 26 remained remain VBD cord-010092-uftc8inx 4349 27 in in IN cord-010092-uftc8inx 4349 28 the the DT cord-010092-uftc8inx 4349 29 blood blood NN cord-010092-uftc8inx 4349 30 bank bank NN cord-010092-uftc8inx 4349 31 . . . cord-010092-uftc8inx 4350 1 A a DT cord-010092-uftc8inx 4350 2 retrospective retrospective JJ cord-010092-uftc8inx 4350 3 review review NN cord-010092-uftc8inx 4350 4 revealed reveal VBD cord-010092-uftc8inx 4350 5 that that IN cord-010092-uftc8inx 4350 6 very very RB cord-010092-uftc8inx 4350 7 few few JJ cord-010092-uftc8inx 4350 8 RBCs rbc NNS cord-010092-uftc8inx 4350 9 were be VBD cord-010092-uftc8inx 4350 10 transfused transfuse VBN cord-010092-uftc8inx 4350 11 ( ( -LRB- cord-010092-uftc8inx 4350 12 2016 2016 CD cord-010092-uftc8inx 4350 13 : : : cord-010092-uftc8inx 4350 14 20 20 CD cord-010092-uftc8inx 4350 15 % % NN cord-010092-uftc8inx 4350 16 ( ( -LRB- cord-010092-uftc8inx 4350 17 371/1813 371/1813 CD cord-010092-uftc8inx 4350 18 ) ) -RRB- cord-010092-uftc8inx 4350 19 , , , cord-010092-uftc8inx 4350 20 2017 2017 CD cord-010092-uftc8inx 4350 21 : : : cord-010092-uftc8inx 4350 22 19 19 CD cord-010092-uftc8inx 4350 23 % % NN cord-010092-uftc8inx 4350 24 ( ( -LRB- cord-010092-uftc8inx 4350 25 322/1742 322/1742 NN cord-010092-uftc8inx 4350 26 ) ) -RRB- cord-010092-uftc8inx 4350 27 ) ) -RRB- cord-010092-uftc8inx 4350 28 . . . cord-010092-uftc8inx 4351 1 Moreover moreover RB cord-010092-uftc8inx 4351 2 , , , cord-010092-uftc8inx 4351 3 approximately approximately RB cord-010092-uftc8inx 4351 4 8 8 CD cord-010092-uftc8inx 4351 5 products product NNS cord-010092-uftc8inx 4351 6 were be VBD cord-010092-uftc8inx 4351 7 wasted waste VBN cord-010092-uftc8inx 4351 8 each each DT cord-010092-uftc8inx 4351 9 month month NN cord-010092-uftc8inx 4351 10 as as IN cord-010092-uftc8inx 4351 11 a a DT cord-010092-uftc8inx 4351 12 direct direct JJ cord-010092-uftc8inx 4351 13 result result NN cord-010092-uftc8inx 4351 14 of of IN cord-010092-uftc8inx 4351 15 this this DT cord-010092-uftc8inx 4351 16 practice practice NN cord-010092-uftc8inx 4351 17 . . . cord-010092-uftc8inx 4352 1 Thus thus RB cord-010092-uftc8inx 4352 2 , , , cord-010092-uftc8inx 4352 3 we -PRON- PRP cord-010092-uftc8inx 4352 4 recognized recognize VBD cord-010092-uftc8inx 4352 5 an an DT cord-010092-uftc8inx 4352 6 opportunity opportunity NN cord-010092-uftc8inx 4352 7 to to TO cord-010092-uftc8inx 4352 8 improve improve VB cord-010092-uftc8inx 4352 9 inventory inventory NN cord-010092-uftc8inx 4352 10 management management NN cord-010092-uftc8inx 4352 11 in in IN cord-010092-uftc8inx 4352 12 terms term NNS cord-010092-uftc8inx 4352 13 of of IN cord-010092-uftc8inx 4352 14 personnel personnel NNS cord-010092-uftc8inx 4352 15 activities activity NNS cord-010092-uftc8inx 4352 16 and and CC cord-010092-uftc8inx 4352 17 blood blood NN cord-010092-uftc8inx 4352 18 component component NN cord-010092-uftc8inx 4352 19 utilization utilization NN cord-010092-uftc8inx 4352 20 . . . cord-010092-uftc8inx 4353 1 Aims aim VBZ cord-010092-uftc8inx 4353 2 : : : cord-010092-uftc8inx 4354 1 The the DT cord-010092-uftc8inx 4354 2 goal goal NN cord-010092-uftc8inx 4354 3 of of IN cord-010092-uftc8inx 4354 4 this this DT cord-010092-uftc8inx 4354 5 study study NN cord-010092-uftc8inx 4354 6 was be VBD cord-010092-uftc8inx 4354 7 to to TO cord-010092-uftc8inx 4354 8 reduce reduce VB cord-010092-uftc8inx 4354 9 advance advance NN cord-010092-uftc8inx 4354 10 preparation preparation NN cord-010092-uftc8inx 4354 11 of of IN cord-010092-uftc8inx 4354 12 coolers cooler NNS cord-010092-uftc8inx 4354 13 in in IN cord-010092-uftc8inx 4354 14 cardiac cardiac JJ cord-010092-uftc8inx 4354 15 surgery surgery NN cord-010092-uftc8inx 4354 16 cases case NNS cord-010092-uftc8inx 4354 17 without without IN cord-010092-uftc8inx 4354 18 compromising compromise VBG cord-010092-uftc8inx 4354 19 patient patient JJ cord-010092-uftc8inx 4354 20 care care NN cord-010092-uftc8inx 4354 21 and and CC cord-010092-uftc8inx 4354 22 safety safety NN cord-010092-uftc8inx 4354 23 . . . cord-010092-uftc8inx 4355 1 We -PRON- PRP cord-010092-uftc8inx 4355 2 limited limit VBD cord-010092-uftc8inx 4355 3 our -PRON- PRP$ cord-010092-uftc8inx 4355 4 intervention intervention NN cord-010092-uftc8inx 4355 5 to to IN cord-010092-uftc8inx 4355 6 those those DT cord-010092-uftc8inx 4355 7 patients patient NNS cord-010092-uftc8inx 4355 8 who who WP cord-010092-uftc8inx 4355 9 were be VBD cord-010092-uftc8inx 4355 10 eligible eligible JJ cord-010092-uftc8inx 4355 11 for for IN cord-010092-uftc8inx 4355 12 electronic electronic JJ cord-010092-uftc8inx 4355 13 crossmatch crossmatch NN cord-010092-uftc8inx 4355 14 . . . cord-010092-uftc8inx 4356 1 We -PRON- PRP cord-010092-uftc8inx 4356 2 maintained maintain VBD cord-010092-uftc8inx 4356 3 the the DT cord-010092-uftc8inx 4356 4 aforementioned aforementioned JJ cord-010092-uftc8inx 4356 5 historical historical JJ cord-010092-uftc8inx 4356 6 practice practice NN cord-010092-uftc8inx 4356 7 for for IN cord-010092-uftc8inx 4356 8 those those DT cord-010092-uftc8inx 4356 9 patients patient NNS cord-010092-uftc8inx 4356 10 with with IN cord-010092-uftc8inx 4356 11 history history NN cord-010092-uftc8inx 4356 12 of of IN cord-010092-uftc8inx 4356 13 and/ and/ CD cord-010092-uftc8inx 4356 14 or or CC cord-010092-uftc8inx 4356 15 those those DT cord-010092-uftc8inx 4356 16 who who WP cord-010092-uftc8inx 4356 17 currently currently RB cord-010092-uftc8inx 4356 18 demonstrated demonstrate VBD cord-010092-uftc8inx 4356 19 clinically clinically RB cord-010092-uftc8inx 4356 20 significant significant JJ cord-010092-uftc8inx 4356 21 red red JJ cord-010092-uftc8inx 4356 22 blood blood NN cord-010092-uftc8inx 4356 23 cell cell NN cord-010092-uftc8inx 4356 24 alloantibodies alloantibody NNS cord-010092-uftc8inx 4356 25 . . . cord-010092-uftc8inx 4357 1 Methods method NNS cord-010092-uftc8inx 4357 2 : : : cord-010092-uftc8inx 4358 1 A a DT cord-010092-uftc8inx 4358 2 multidisciplinary multidisciplinary JJ cord-010092-uftc8inx 4358 3 group group NN cord-010092-uftc8inx 4358 4 consisting consist VBG cord-010092-uftc8inx 4358 5 of of IN cord-010092-uftc8inx 4358 6 representatives representative NNS cord-010092-uftc8inx 4358 7 from from IN cord-010092-uftc8inx 4358 8 the the DT cord-010092-uftc8inx 4358 9 blood blood NN cord-010092-uftc8inx 4358 10 bank bank NN cord-010092-uftc8inx 4358 11 , , , cord-010092-uftc8inx 4358 12 cardiac cardiac JJ cord-010092-uftc8inx 4358 13 surgery surgery NN cord-010092-uftc8inx 4358 14 , , , cord-010092-uftc8inx 4358 15 cardiac cardiac JJ cord-010092-uftc8inx 4358 16 nursing nursing NN cord-010092-uftc8inx 4358 17 , , , cord-010092-uftc8inx 4358 18 cardiac cardiac JJ cord-010092-uftc8inx 4358 19 anesthesia anesthesia NN cord-010092-uftc8inx 4358 20 and and CC cord-010092-uftc8inx 4358 21 surgery surgery NN cord-010092-uftc8inx 4358 22 quality quality NNP cord-010092-uftc8inx 4358 23 department department NN cord-010092-uftc8inx 4358 24 was be VBD cord-010092-uftc8inx 4358 25 assembled assemble VBN cord-010092-uftc8inx 4358 26 in in IN cord-010092-uftc8inx 4358 27 October October NNP cord-010092-uftc8inx 4358 28 2017 2017 CD cord-010092-uftc8inx 4358 29 to to TO cord-010092-uftc8inx 4358 30 determine determine VB cord-010092-uftc8inx 4358 31 whether whether IN cord-010092-uftc8inx 4358 32 a a DT cord-010092-uftc8inx 4358 33 modification modification NN cord-010092-uftc8inx 4358 34 of of IN cord-010092-uftc8inx 4358 35 practice practice NN cord-010092-uftc8inx 4358 36 was be VBD cord-010092-uftc8inx 4358 37 reasonable reasonable JJ cord-010092-uftc8inx 4358 38 and and CC cord-010092-uftc8inx 4358 39 safe safe JJ cord-010092-uftc8inx 4358 40 . . . cord-010092-uftc8inx 4359 1 Group group NN cord-010092-uftc8inx 4359 2 members member NNS cord-010092-uftc8inx 4359 3 evaluated evaluate VBD cord-010092-uftc8inx 4359 4 site site NN cord-010092-uftc8inx 4359 5 specific specific JJ cord-010092-uftc8inx 4359 6 Society Society NNP cord-010092-uftc8inx 4359 7 of of IN cord-010092-uftc8inx 4359 8 Thoracic thoracic JJ cord-010092-uftc8inx 4359 9 Surgery surgery NN cord-010092-uftc8inx 4359 10 ( ( -LRB- cord-010092-uftc8inx 4359 11 STS STS NNP cord-010092-uftc8inx 4359 12 ) ) -RRB- cord-010092-uftc8inx 4359 13 cardiac cardiac JJ cord-010092-uftc8inx 4359 14 surgical surgical JJ cord-010092-uftc8inx 4359 15 data datum NNS cord-010092-uftc8inx 4359 16 between between IN cord-010092-uftc8inx 4359 17 July July NNP cord-010092-uftc8inx 4359 18 2014 2014 CD cord-010092-uftc8inx 4359 19 and and CC cord-010092-uftc8inx 4359 20 December December NNP cord-010092-uftc8inx 4359 21 2016 2016 CD cord-010092-uftc8inx 4359 22 to to TO cord-010092-uftc8inx 4359 23 establish establish VB cord-010092-uftc8inx 4359 24 intraoperative intraoperative JJ cord-010092-uftc8inx 4359 25 red red JJ cord-010092-uftc8inx 4359 26 cell cell NN cord-010092-uftc8inx 4359 27 transfusion transfusion NN cord-010092-uftc8inx 4359 28 rates rate NNS cord-010092-uftc8inx 4359 29 classified classify VBN cord-010092-uftc8inx 4359 30 by by IN cord-010092-uftc8inx 4359 31 type type NN cord-010092-uftc8inx 4359 32 and and CC cord-010092-uftc8inx 4359 33 urgency urgency NN cord-010092-uftc8inx 4359 34 of of IN cord-010092-uftc8inx 4359 35 surgery surgery NN cord-010092-uftc8inx 4359 36 . . . cord-010092-uftc8inx 4360 1 The the DT cord-010092-uftc8inx 4360 2 group group NN cord-010092-uftc8inx 4360 3 's 's POS cord-010092-uftc8inx 4360 4 main main JJ cord-010092-uftc8inx 4360 5 goal goal NN cord-010092-uftc8inx 4360 6 was be VBD cord-010092-uftc8inx 4360 7 to to TO cord-010092-uftc8inx 4360 8 discontinue discontinue VB cord-010092-uftc8inx 4360 9 preparation preparation NN cord-010092-uftc8inx 4360 10 of of IN cord-010092-uftc8inx 4360 11 default default NN cord-010092-uftc8inx 4360 12 coolers cooler NNS cord-010092-uftc8inx 4360 13 for for IN cord-010092-uftc8inx 4360 14 patients patient NNS cord-010092-uftc8inx 4360 15 eligible eligible JJ cord-010092-uftc8inx 4360 16 for for IN cord-010092-uftc8inx 4360 17 electronic electronic JJ cord-010092-uftc8inx 4360 18 crossmatch crossmatch NN cord-010092-uftc8inx 4360 19 who who WP cord-010092-uftc8inx 4360 20 were be VBD cord-010092-uftc8inx 4360 21 scheduled schedule VBN cord-010092-uftc8inx 4360 22 for for IN cord-010092-uftc8inx 4360 23 all all DT cord-010092-uftc8inx 4360 24 types type NNS cord-010092-uftc8inx 4360 25 of of IN cord-010092-uftc8inx 4360 26 non non JJ cord-010092-uftc8inx 4360 27 - - JJ cord-010092-uftc8inx 4360 28 emergency emergency JJ cord-010092-uftc8inx 4360 29 cardiac cardiac NN cord-010092-uftc8inx 4360 30 surgery surgery NN cord-010092-uftc8inx 4360 31 cases case NNS cord-010092-uftc8inx 4360 32 in in IN cord-010092-uftc8inx 4360 33 which which WDT cord-010092-uftc8inx 4360 34 ≤ ≤ NNP cord-010092-uftc8inx 4360 35 25 25 CD cord-010092-uftc8inx 4360 36 % % NN cord-010092-uftc8inx 4360 37 of of IN cord-010092-uftc8inx 4360 38 historical historical JJ cord-010092-uftc8inx 4360 39 cases case NNS cord-010092-uftc8inx 4360 40 required require VBN cord-010092-uftc8inx 4360 41 at at RB cord-010092-uftc8inx 4360 42 least least RBS cord-010092-uftc8inx 4360 43 one one CD cord-010092-uftc8inx 4360 44 red red JJ cord-010092-uftc8inx 4360 45 cell cell NN cord-010092-uftc8inx 4360 46 transfusion transfusion NN cord-010092-uftc8inx 4360 47 . . . cord-010092-uftc8inx 4361 1 Additionally additionally RB cord-010092-uftc8inx 4361 2 , , , cord-010092-uftc8inx 4361 3 team team NN cord-010092-uftc8inx 4361 4 members member NNS cord-010092-uftc8inx 4361 5 simulated simulate VBD cord-010092-uftc8inx 4361 6 the the DT cord-010092-uftc8inx 4361 7 multiple multiple JJ cord-010092-uftc8inx 4361 8 protocols protocol NNS cord-010092-uftc8inx 4361 9 by by IN cord-010092-uftc8inx 4361 10 which which WDT cord-010092-uftc8inx 4361 11 red red JJ cord-010092-uftc8inx 4361 12 blood blood NN cord-010092-uftc8inx 4361 13 cells cell NNS cord-010092-uftc8inx 4361 14 could could MD cord-010092-uftc8inx 4361 15 be be VB cord-010092-uftc8inx 4361 16 prepared prepare VBN cord-010092-uftc8inx 4361 17 and and CC cord-010092-uftc8inx 4361 18 delivered deliver VBN cord-010092-uftc8inx 4361 19 to to IN cord-010092-uftc8inx 4361 20 the the DT cord-010092-uftc8inx 4361 21 OR OR NNP cord-010092-uftc8inx 4361 22 and and CC cord-010092-uftc8inx 4361 23 estimated estimate VBD cord-010092-uftc8inx 4361 24 the the DT cord-010092-uftc8inx 4361 25 time time NN cord-010092-uftc8inx 4361 26 for for IN cord-010092-uftc8inx 4361 27 each each DT cord-010092-uftc8inx 4361 28 scenario scenario NN cord-010092-uftc8inx 4361 29 . . . cord-010092-uftc8inx 4362 1 Results result NNS cord-010092-uftc8inx 4362 2 : : : cord-010092-uftc8inx 4363 1 Review Review NNP cord-010092-uftc8inx 4363 2 of of IN cord-010092-uftc8inx 4363 3 STS STS NNP cord-010092-uftc8inx 4363 4 data datum NNS cord-010092-uftc8inx 4363 5 showed show VBD cord-010092-uftc8inx 4363 6 that that IN cord-010092-uftc8inx 4363 7 the the DT cord-010092-uftc8inx 4363 8 following follow VBG cord-010092-uftc8inx 4363 9 cases case NNS cord-010092-uftc8inx 4363 10 met meet VBD cord-010092-uftc8inx 4363 11 the the DT cord-010092-uftc8inx 4363 12 criteria criterion NNS cord-010092-uftc8inx 4363 13 of of IN cord-010092-uftc8inx 4363 14 ≤ ≤ $ cord-010092-uftc8inx 4363 15 25 25 CD cord-010092-uftc8inx 4363 16 % % NN cord-010092-uftc8inx 4363 17 : : : cord-010092-uftc8inx 4363 18 elective elective JJ cord-010092-uftc8inx 4363 19 primary primary JJ cord-010092-uftc8inx 4363 20 coronary coronary JJ cord-010092-uftc8inx 4363 21 artery artery NN cord-010092-uftc8inx 4363 22 bypass bypass NN cord-010092-uftc8inx 4363 23 graft graft NN cord-010092-uftc8inx 4363 24 ( ( -LRB- cord-010092-uftc8inx 4363 25 CABG CABG NNP cord-010092-uftc8inx 4363 26 ) ) -RRB- cord-010092-uftc8inx 4363 27 , , , cord-010092-uftc8inx 4363 28 urgent urgent JJ cord-010092-uftc8inx 4363 29 primary primary JJ cord-010092-uftc8inx 4363 30 CABG CABG NNP cord-010092-uftc8inx 4363 31 , , , cord-010092-uftc8inx 4363 32 elective elective JJ cord-010092-uftc8inx 4363 33 mitral mitral JJ cord-010092-uftc8inx 4363 34 valve valve NN cord-010092-uftc8inx 4363 35 repairs repair NNS cord-010092-uftc8inx 4363 36 , , , cord-010092-uftc8inx 4363 37 and and CC cord-010092-uftc8inx 4363 38 elective elective JJ cord-010092-uftc8inx 4363 39 aortic aortic JJ cord-010092-uftc8inx 4363 40 valve valve NN cord-010092-uftc8inx 4363 41 replacements replacement NNS cord-010092-uftc8inx 4363 42 . . . cord-010092-uftc8inx 4364 1 Simulation simulation NN cord-010092-uftc8inx 4364 2 showed show VBD cord-010092-uftc8inx 4364 3 that that IN cord-010092-uftc8inx 4364 4 , , , cord-010092-uftc8inx 4364 5 in in IN cord-010092-uftc8inx 4364 6 patients patient NNS cord-010092-uftc8inx 4364 7 eligible eligible JJ cord-010092-uftc8inx 4364 8 for for IN cord-010092-uftc8inx 4364 9 electronic electronic JJ cord-010092-uftc8inx 4364 10 crossmatch crossmatch NN cord-010092-uftc8inx 4364 11 , , , cord-010092-uftc8inx 4364 12 preparation preparation NN cord-010092-uftc8inx 4364 13 from from IN cord-010092-uftc8inx 4364 14 receipt receipt NN cord-010092-uftc8inx 4364 15 of of IN cord-010092-uftc8inx 4364 16 order order NN cord-010092-uftc8inx 4364 17 to to IN cord-010092-uftc8inx 4364 18 completion completion NN cord-010092-uftc8inx 4364 19 of of IN cord-010092-uftc8inx 4364 20 unit unit NN cord-010092-uftc8inx 4364 21 packing pack VBG cord-010092-uftc8inx 4364 22 for for IN cord-010092-uftc8inx 4364 23 delivery delivery NN cord-010092-uftc8inx 4364 24 took take VBD cord-010092-uftc8inx 4364 25 2.5 2.5 CD cord-010092-uftc8inx 4364 26 min min NN cord-010092-uftc8inx 4364 27 using use VBG cord-010092-uftc8inx 4364 28 the the DT cord-010092-uftc8inx 4364 29 pneumatic pneumatic JJ cord-010092-uftc8inx 4364 30 tube tube NN cord-010092-uftc8inx 4364 31 system system NN cord-010092-uftc8inx 4364 32 ( ( -LRB- cord-010092-uftc8inx 4364 33 maximum maximum NN cord-010092-uftc8inx 4364 34 of of IN cord-010092-uftc8inx 4364 35 2 2 CD cord-010092-uftc8inx 4364 36 units unit NNS cord-010092-uftc8inx 4364 37 per per IN cord-010092-uftc8inx 4364 38 tube tube NN cord-010092-uftc8inx 4364 39 ) ) -RRB- cord-010092-uftc8inx 4364 40 and and CC cord-010092-uftc8inx 4364 41 4.5 4.5 CD cord-010092-uftc8inx 4364 42 min min NN cord-010092-uftc8inx 4364 43 using use VBG cord-010092-uftc8inx 4364 44 delivery delivery NN cord-010092-uftc8inx 4364 45 of of IN cord-010092-uftc8inx 4364 46 a a DT cord-010092-uftc8inx 4364 47 cooler cooler NN cord-010092-uftc8inx 4364 48 using use VBG cord-010092-uftc8inx 4364 49 a a DT cord-010092-uftc8inx 4364 50 human human JJ cord-010092-uftc8inx 4364 51 courier courier NN cord-010092-uftc8inx 4364 52 . . . cord-010092-uftc8inx 4365 1 Summary Summary NNP cord-010092-uftc8inx 4365 2 / / SYM cord-010092-uftc8inx 4365 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 4365 4 : : : cord-010092-uftc8inx 4366 1 Based base VBN cord-010092-uftc8inx 4366 2 on on IN cord-010092-uftc8inx 4366 3 the the DT cord-010092-uftc8inx 4366 4 simulation simulation NN cord-010092-uftc8inx 4366 5 results result NNS cord-010092-uftc8inx 4366 6 , , , cord-010092-uftc8inx 4366 7 and and CC cord-010092-uftc8inx 4366 8 with with IN cord-010092-uftc8inx 4366 9 consensus consensus NN cord-010092-uftc8inx 4366 10 agreement agreement NN cord-010092-uftc8inx 4366 11 from from IN cord-010092-uftc8inx 4366 12 the the DT cord-010092-uftc8inx 4366 13 multidisciplinary multidisciplinary JJ cord-010092-uftc8inx 4366 14 group group NN cord-010092-uftc8inx 4366 15 , , , cord-010092-uftc8inx 4366 16 default default JJ cord-010092-uftc8inx 4366 17 cooler cool JJR cord-010092-uftc8inx 4366 18 preparation preparation NN cord-010092-uftc8inx 4366 19 for for IN cord-010092-uftc8inx 4366 20 elective elective JJ cord-010092-uftc8inx 4366 21 primary primary JJ cord-010092-uftc8inx 4366 22 CABG CABG NNP cord-010092-uftc8inx 4366 23 , , , cord-010092-uftc8inx 4366 24 urgent urgent JJ cord-010092-uftc8inx 4366 25 primary primary JJ cord-010092-uftc8inx 4366 26 CABG CABG NNP cord-010092-uftc8inx 4366 27 , , , cord-010092-uftc8inx 4366 28 elective elective JJ cord-010092-uftc8inx 4366 29 MVR MVR NNP cord-010092-uftc8inx 4366 30 , , , cord-010092-uftc8inx 4366 31 and and CC cord-010092-uftc8inx 4366 32 elective elective JJ cord-010092-uftc8inx 4366 33 AVR AVR NNP cord-010092-uftc8inx 4366 34 was be VBD cord-010092-uftc8inx 4366 35 discontinued discontinue VBN cord-010092-uftc8inx 4366 36 in in IN cord-010092-uftc8inx 4366 37 December December NNP cord-010092-uftc8inx 4366 38 2017 2017 CD cord-010092-uftc8inx 4366 39 . . . cord-010092-uftc8inx 4367 1 One one CD cord-010092-uftc8inx 4367 2 year year NN cord-010092-uftc8inx 4367 3 following follow VBG cord-010092-uftc8inx 4367 4 implementation implementation NN cord-010092-uftc8inx 4367 5 of of IN cord-010092-uftc8inx 4367 6 the the DT cord-010092-uftc8inx 4367 7 change change NN cord-010092-uftc8inx 4367 8 in in IN cord-010092-uftc8inx 4367 9 policy policy NN cord-010092-uftc8inx 4367 10 940 940 CD cord-010092-uftc8inx 4367 11 RBC RBC NNP cord-010092-uftc8inx 4367 12 units unit NNS cord-010092-uftc8inx 4367 13 were be VBD cord-010092-uftc8inx 4367 14 issued issue VBN cord-010092-uftc8inx 4367 15 to to IN cord-010092-uftc8inx 4367 16 the the DT cord-010092-uftc8inx 4367 17 OR OR NNP cord-010092-uftc8inx 4367 18 ( ( -LRB- cord-010092-uftc8inx 4367 19 a a DT cord-010092-uftc8inx 4367 20 54 54 CD cord-010092-uftc8inx 4367 21 % % NN cord-010092-uftc8inx 4367 22 reduction reduction NN cord-010092-uftc8inx 4367 23 ) ) -RRB- cord-010092-uftc8inx 4367 24 ; ; : cord-010092-uftc8inx 4367 25 38 38 CD cord-010092-uftc8inx 4367 26 % % NN cord-010092-uftc8inx 4367 27 ( ( -LRB- cord-010092-uftc8inx 4367 28 361 361 CD cord-010092-uftc8inx 4367 29 ) ) -RRB- cord-010092-uftc8inx 4367 30 were be VBD cord-010092-uftc8inx 4367 31 transfused transfuse VBN cord-010092-uftc8inx 4367 32 , , , cord-010092-uftc8inx 4367 33 compared compare VBN cord-010092-uftc8inx 4367 34 to to IN cord-010092-uftc8inx 4367 35 19 19 CD cord-010092-uftc8inx 4367 36 % % NN cord-010092-uftc8inx 4367 37 in in IN cord-010092-uftc8inx 4367 38 2017 2017 CD cord-010092-uftc8inx 4367 39 . . . cord-010092-uftc8inx 4368 1 Wastage wastage NN cord-010092-uftc8inx 4368 2 rates rate NNS cord-010092-uftc8inx 4368 3 decreased decrease VBD cord-010092-uftc8inx 4368 4 from from IN cord-010092-uftc8inx 4368 5 8 8 CD cord-010092-uftc8inx 4368 6 products product NNS cord-010092-uftc8inx 4368 7 a a DT cord-010092-uftc8inx 4368 8 month month NN cord-010092-uftc8inx 4368 9 to to IN cord-010092-uftc8inx 4368 10 1 1 CD cord-010092-uftc8inx 4368 11 per per IN cord-010092-uftc8inx 4368 12 month month NN cord-010092-uftc8inx 4368 13 on on IN cord-010092-uftc8inx 4368 14 average average JJ cord-010092-uftc8inx 4368 15 . . . cord-010092-uftc8inx 4369 1 Summary Summary NNP cord-010092-uftc8inx 4369 2 / / SYM cord-010092-uftc8inx 4369 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 4369 4 : : : cord-010092-uftc8inx 4370 1 The the DT cord-010092-uftc8inx 4370 2 most most RBS cord-010092-uftc8inx 4370 3 obvious obvious JJ cord-010092-uftc8inx 4370 4 drawback drawback NN cord-010092-uftc8inx 4370 5 of of IN cord-010092-uftc8inx 4370 6 PABD PABD NNP cord-010092-uftc8inx 4370 7 is be VBZ cord-010092-uftc8inx 4370 8 the the DT cord-010092-uftc8inx 4370 9 higher high JJR cord-010092-uftc8inx 4370 10 cost cost NN cord-010092-uftc8inx 4370 11 in in IN cord-010092-uftc8inx 4370 12 running run VBG cord-010092-uftc8inx 4370 13 the the DT cord-010092-uftc8inx 4370 14 program program NN cord-010092-uftc8inx 4370 15 in in IN cord-010092-uftc8inx 4370 16 comparison comparison NN cord-010092-uftc8inx 4370 17 with with IN cord-010092-uftc8inx 4370 18 collection collection NN cord-010092-uftc8inx 4370 19 of of IN cord-010092-uftc8inx 4370 20 allogeneic allogeneic NN cord-010092-uftc8inx 4370 21 blood blood NN cord-010092-uftc8inx 4370 22 in in IN cord-010092-uftc8inx 4370 23 the the DT cord-010092-uftc8inx 4370 24 areas area NNS cord-010092-uftc8inx 4370 25 of of IN cord-010092-uftc8inx 4370 26 additional additional JJ cord-010092-uftc8inx 4370 27 patient patient JJ cord-010092-uftc8inx 4370 28 attention attention NN cord-010092-uftc8inx 4370 29 and and CC cord-010092-uftc8inx 4370 30 clerical clerical JJ cord-010092-uftc8inx 4370 31 input input NN cord-010092-uftc8inx 4370 32 in in IN cord-010092-uftc8inx 4370 33 labeling labeling NN cord-010092-uftc8inx 4370 34 , , , cord-010092-uftc8inx 4370 35 separate separate JJ cord-010092-uftc8inx 4370 36 storage storage NN cord-010092-uftc8inx 4370 37 and and CC cord-010092-uftc8inx 4370 38 so so RB cord-010092-uftc8inx 4370 39 on on RB cord-010092-uftc8inx 4370 40 . . . cord-010092-uftc8inx 4371 1 In in IN cord-010092-uftc8inx 4371 2 this this DT cord-010092-uftc8inx 4371 3 audit audit NN cord-010092-uftc8inx 4371 4 , , , cord-010092-uftc8inx 4371 5 34 34 CD cord-010092-uftc8inx 4371 6 % % NN cord-010092-uftc8inx 4371 7 of of IN cord-010092-uftc8inx 4371 8 the the DT cord-010092-uftc8inx 4371 9 autologous autologous JJ cord-010092-uftc8inx 4371 10 blood blood NN cord-010092-uftc8inx 4371 11 components component NNS cord-010092-uftc8inx 4371 12 were be VBD cord-010092-uftc8inx 4371 13 not not RB cord-010092-uftc8inx 4371 14 transfused transfuse VBN cord-010092-uftc8inx 4371 15 into into IN cord-010092-uftc8inx 4371 16 the the DT cord-010092-uftc8inx 4371 17 intended intend VBN cord-010092-uftc8inx 4371 18 recipients recipient NNS cord-010092-uftc8inx 4371 19 and and CC cord-010092-uftc8inx 4371 20 wasted waste VBN cord-010092-uftc8inx 4371 21 ; ; : cord-010092-uftc8inx 4371 22 in in IN cord-010092-uftc8inx 4371 23 this this DT cord-010092-uftc8inx 4371 24 context context NN cord-010092-uftc8inx 4371 25 , , , cord-010092-uftc8inx 4371 26 the the DT cord-010092-uftc8inx 4371 27 PABD PABD NNP cord-010092-uftc8inx 4371 28 program program NN cord-010092-uftc8inx 4371 29 could could MD cord-010092-uftc8inx 4371 30 not not RB cord-010092-uftc8inx 4371 31 be be VB cord-010092-uftc8inx 4371 32 considered consider VBN cord-010092-uftc8inx 4371 33 as as IN cord-010092-uftc8inx 4371 34 a a DT cord-010092-uftc8inx 4371 35 cost cost NN cord-010092-uftc8inx 4371 36 - - HYPH cord-010092-uftc8inx 4371 37 effective effective JJ cord-010092-uftc8inx 4371 38 approach approach NN cord-010092-uftc8inx 4371 39 in in IN cord-010092-uftc8inx 4371 40 protecting protect VBG cord-010092-uftc8inx 4371 41 blood blood NN cord-010092-uftc8inx 4371 42 safety safety NN cord-010092-uftc8inx 4371 43 . . . cord-010092-uftc8inx 4372 1 Background background NN cord-010092-uftc8inx 4372 2 : : : cord-010092-uftc8inx 4373 1 The the DT cord-010092-uftc8inx 4373 2 National National NNP cord-010092-uftc8inx 4373 3 Blood Blood NNP cord-010092-uftc8inx 4373 4 Service Service NNP cord-010092-uftc8inx 4373 5 Zimbabwe Zimbabwe NNP cord-010092-uftc8inx 4373 6 ( ( -LRB- cord-010092-uftc8inx 4373 7 NBSZ NBSZ NNP cord-010092-uftc8inx 4373 8 ) ) -RRB- cord-010092-uftc8inx 4373 9 's 's POS cord-010092-uftc8inx 4373 10 Blood Blood NNP cord-010092-uftc8inx 4373 11 Supply Supply NNP cord-010092-uftc8inx 4373 12 Management Management NNP cord-010092-uftc8inx 4373 13 Status status NN cord-010092-uftc8inx 4373 14 ( ( -LRB- cord-010092-uftc8inx 4373 15 BSMS BSMS NNP cord-010092-uftc8inx 4373 16 ) ) -RRB- cord-010092-uftc8inx 4373 17 is be VBZ cord-010092-uftc8inx 4373 18 an an DT cord-010092-uftc8inx 4373 19 integral integral JJ cord-010092-uftc8inx 4373 20 process process NN cord-010092-uftc8inx 4373 21 of of IN cord-010092-uftc8inx 4373 22 ensuring ensure VBG cord-010092-uftc8inx 4373 23 the the DT cord-010092-uftc8inx 4373 24 availability availability NN cord-010092-uftc8inx 4373 25 of of IN cord-010092-uftc8inx 4373 26 a a DT cord-010092-uftc8inx 4373 27 safe safe JJ cord-010092-uftc8inx 4373 28 and and CC cord-010092-uftc8inx 4373 29 sufficient sufficient JJ cord-010092-uftc8inx 4373 30 blood blood NN cord-010092-uftc8inx 4373 31 supply supply NN cord-010092-uftc8inx 4373 32 provision provision NN cord-010092-uftc8inx 4373 33 . . . cord-010092-uftc8inx 4374 1 NBSZ NBSZ NNP cord-010092-uftc8inx 4374 2 introduced introduce VBD cord-010092-uftc8inx 4374 3 a a DT cord-010092-uftc8inx 4374 4 new new JJ cord-010092-uftc8inx 4374 5 daily daily JJ cord-010092-uftc8inx 4374 6 blood blood NN cord-010092-uftc8inx 4374 7 bank bank NN cord-010092-uftc8inx 4374 8 statement statement NN cord-010092-uftc8inx 4374 9 with with IN cord-010092-uftc8inx 4374 10 improved improved JJ cord-010092-uftc8inx 4374 11 metrics metric NNS cord-010092-uftc8inx 4374 12 from from IN cord-010092-uftc8inx 4374 13 1 1 CD cord-010092-uftc8inx 4374 14 May May NNP cord-010092-uftc8inx 4374 15 2018 2018 CD cord-010092-uftc8inx 4374 16 . . . cord-010092-uftc8inx 4375 1 The the DT cord-010092-uftc8inx 4375 2 new new JJ cord-010092-uftc8inx 4375 3 analytics analytic NNS cord-010092-uftc8inx 4375 4 approach approach NN cord-010092-uftc8inx 4375 5 focuses focus VBZ cord-010092-uftc8inx 4375 6 on on IN cord-010092-uftc8inx 4375 7 three three CD cord-010092-uftc8inx 4375 8 interactive interactive JJ cord-010092-uftc8inx 4375 9 components component NNS cord-010092-uftc8inx 4375 10 of of IN cord-010092-uftc8inx 4375 11 the the DT cord-010092-uftc8inx 4375 12 blood blood NN cord-010092-uftc8inx 4375 13 bank bank NN cord-010092-uftc8inx 4375 14 statement statement NN cord-010092-uftc8inx 4375 15 ; ; : cord-010092-uftc8inx 4375 16 the the DT cord-010092-uftc8inx 4375 17 available available JJ cord-010092-uftc8inx 4375 18 stock stock NN cord-010092-uftc8inx 4375 19 , , , cord-010092-uftc8inx 4375 20 quarantine quarantine NN cord-010092-uftc8inx 4375 21 stock stock NN cord-010092-uftc8inx 4375 22 ( ( -LRB- cord-010092-uftc8inx 4375 23 as as IN cord-010092-uftc8inx 4375 24 per per IN cord-010092-uftc8inx 4375 25 the the DT cord-010092-uftc8inx 4375 26 desired desire VBN cord-010092-uftc8inx 4375 27 5-days 5-days CD cord-010092-uftc8inx 4375 28 stocks stock NNS cord-010092-uftc8inx 4375 29 level level NN cord-010092-uftc8inx 4375 30 ) ) -RRB- cord-010092-uftc8inx 4375 31 , , , cord-010092-uftc8inx 4375 32 and and CC cord-010092-uftc8inx 4375 33 the the DT cord-010092-uftc8inx 4375 34 demand demand NN cord-010092-uftc8inx 4375 35 versus versus IN cord-010092-uftc8inx 4375 36 supply supply NN cord-010092-uftc8inx 4375 37 . . . cord-010092-uftc8inx 4376 1 It -PRON- PRP cord-010092-uftc8inx 4376 2 is be VBZ cord-010092-uftc8inx 4376 3 imperative imperative JJ cord-010092-uftc8inx 4376 4 to to TO cord-010092-uftc8inx 4376 5 have have VB cord-010092-uftc8inx 4376 6 a a DT cord-010092-uftc8inx 4376 7 closely closely RB cord-010092-uftc8inx 4376 8 monitored monitor VBN cord-010092-uftc8inx 4376 9 blood blood NN cord-010092-uftc8inx 4376 10 supply supply NN cord-010092-uftc8inx 4376 11 chain chain NN cord-010092-uftc8inx 4376 12 because because IN cord-010092-uftc8inx 4376 13 blood blood NN cord-010092-uftc8inx 4376 14 has have VBZ cord-010092-uftc8inx 4376 15 limited limit VBN cord-010092-uftc8inx 4376 16 shelf shelf NN cord-010092-uftc8inx 4376 17 life life NN cord-010092-uftc8inx 4376 18 with with IN cord-010092-uftc8inx 4376 19 uncertainties uncertainty NNS cord-010092-uftc8inx 4376 20 in in IN cord-010092-uftc8inx 4376 21 both both DT cord-010092-uftc8inx 4376 22 supply supply NN cord-010092-uftc8inx 4376 23 and and CC cord-010092-uftc8inx 4376 24 demand demand NN cord-010092-uftc8inx 4376 25 . . . cord-010092-uftc8inx 4377 1 The the DT cord-010092-uftc8inx 4377 2 ' ' `` cord-010092-uftc8inx 4377 3 blood blood NN cord-010092-uftc8inx 4377 4 - - HYPH cord-010092-uftc8inx 4377 5 for for IN cord-010092-uftc8inx 4377 6 - - HYPH cord-010092-uftc8inx 4377 7 free free JJ cord-010092-uftc8inx 4377 8 ' ' '' cord-010092-uftc8inx 4377 9 proclamation proclamation NN cord-010092-uftc8inx 4377 10 by by IN cord-010092-uftc8inx 4377 11 the the DT cord-010092-uftc8inx 4377 12 Government Government NNP cord-010092-uftc8inx 4377 13 of of IN cord-010092-uftc8inx 4377 14 Zimbabwe Zimbabwe NNP cord-010092-uftc8inx 4377 15 in in IN cord-010092-uftc8inx 4377 16 July July NNP cord-010092-uftc8inx 4377 17 2018 2018 CD cord-010092-uftc8inx 4377 18 set set VBD cord-010092-uftc8inx 4377 19 more more JJR cord-010092-uftc8inx 4377 20 pressure pressure NN cord-010092-uftc8inx 4377 21 on on IN cord-010092-uftc8inx 4377 22 the the DT cord-010092-uftc8inx 4377 23 blood blood NN cord-010092-uftc8inx 4377 24 demand demand NN cord-010092-uftc8inx 4377 25 . . . cord-010092-uftc8inx 4378 1 These these DT cord-010092-uftc8inx 4378 2 metric metric RB cord-010092-uftc8inx 4378 3 - - HYPH cord-010092-uftc8inx 4378 4 based base VBN cord-010092-uftc8inx 4378 5 analytics analytic NNS cord-010092-uftc8inx 4378 6 seek seek VBP cord-010092-uftc8inx 4378 7 to to TO cord-010092-uftc8inx 4378 8 assess assess VB cord-010092-uftc8inx 4378 9 if if IN cord-010092-uftc8inx 4378 10 the the DT cord-010092-uftc8inx 4378 11 NBSZ NBSZ NNP cord-010092-uftc8inx 4378 12 's 's POS cord-010092-uftc8inx 4378 13 improved improved JJ cord-010092-uftc8inx 4378 14 blood blood NN cord-010092-uftc8inx 4378 15 bank bank NN cord-010092-uftc8inx 4378 16 statement statement NN cord-010092-uftc8inx 4378 17 is be VBZ cord-010092-uftc8inx 4378 18 a a DT cord-010092-uftc8inx 4378 19 realistic realistic JJ cord-010092-uftc8inx 4378 20 model model NN cord-010092-uftc8inx 4378 21 for for IN cord-010092-uftc8inx 4378 22 the the DT cord-010092-uftc8inx 4378 23 BSMS BSMS NNP cord-010092-uftc8inx 4378 24 . . . cord-010092-uftc8inx 4379 1 Aims aim VBZ cord-010092-uftc8inx 4379 2 : : : cord-010092-uftc8inx 4380 1 To to TO cord-010092-uftc8inx 4380 2 assess assess VB cord-010092-uftc8inx 4380 3 the the DT cord-010092-uftc8inx 4380 4 use use NN cord-010092-uftc8inx 4380 5 of of IN cord-010092-uftc8inx 4380 6 the the DT cord-010092-uftc8inx 4380 7 interactive interactive JJ cord-010092-uftc8inx 4380 8 metrics metric NNS cord-010092-uftc8inx 4380 9 in in IN cord-010092-uftc8inx 4380 10 monitoring monitor VBG cord-010092-uftc8inx 4380 11 the the DT cord-010092-uftc8inx 4380 12 blood blood NN cord-010092-uftc8inx 4380 13 supply supply NN cord-010092-uftc8inx 4380 14 management management NN cord-010092-uftc8inx 4380 15 status status NN cord-010092-uftc8inx 4380 16 . . . cord-010092-uftc8inx 4381 1 Methods method NNS cord-010092-uftc8inx 4381 2 : : : cord-010092-uftc8inx 4382 1 A a DT cord-010092-uftc8inx 4382 2 prospective prospective JJ cord-010092-uftc8inx 4382 3 cross cross JJ cord-010092-uftc8inx 4382 4 - - JJ cord-010092-uftc8inx 4382 5 sectional sectional JJ cord-010092-uftc8inx 4382 6 study study NN cord-010092-uftc8inx 4382 7 was be VBD cord-010092-uftc8inx 4382 8 conducted conduct VBN cord-010092-uftc8inx 4382 9 . . . cord-010092-uftc8inx 4383 1 A a DT cord-010092-uftc8inx 4383 2 total total NN cord-010092-uftc8inx 4383 3 of of IN cord-010092-uftc8inx 4383 4 704 704 CD cord-010092-uftc8inx 4383 5 daily daily JJ cord-010092-uftc8inx 4383 6 blood blood NN cord-010092-uftc8inx 4383 7 bank bank NN cord-010092-uftc8inx 4383 8 statements statement NNS cord-010092-uftc8inx 4383 9 which which WDT cord-010092-uftc8inx 4383 10 were be VBD cord-010092-uftc8inx 4383 11 submitted submit VBN cord-010092-uftc8inx 4383 12 between between IN cord-010092-uftc8inx 4383 13 May May NNP cord-010092-uftc8inx 4383 14 and and CC cord-010092-uftc8inx 4383 15 December December NNP cord-010092-uftc8inx 4383 16 2018 2018 CD cord-010092-uftc8inx 4383 17 from from IN cord-010092-uftc8inx 4383 18 each each DT cord-010092-uftc8inx 4383 19 of of IN cord-010092-uftc8inx 4383 20 the the DT cord-010092-uftc8inx 4383 21 five five CD cord-010092-uftc8inx 4383 22 branches branch NNS cord-010092-uftc8inx 4383 23 were be VBD cord-010092-uftc8inx 4383 24 analyzed analyze VBN cord-010092-uftc8inx 4383 25 . . . cord-010092-uftc8inx 4384 1 The the DT cord-010092-uftc8inx 4384 2 BSMS BSMS NNP cord-010092-uftc8inx 4384 3 which which WDT cord-010092-uftc8inx 4384 4 is be VBZ cord-010092-uftc8inx 4384 5 calculated calculate VBN cord-010092-uftc8inx 4384 6 as as IN cord-010092-uftc8inx 4384 7 the the DT cord-010092-uftc8inx 4384 8 average average NN cord-010092-uftc8inx 4384 9 of of IN cord-010092-uftc8inx 4384 10 the the DT cord-010092-uftc8inx 4384 11 three three CD cord-010092-uftc8inx 4384 12 interactive interactive JJ cord-010092-uftc8inx 4384 13 measures measure NNS cord-010092-uftc8inx 4384 14 of of IN cord-010092-uftc8inx 4384 15 quarantine quarantine NN cord-010092-uftc8inx 4384 16 stock stock NN cord-010092-uftc8inx 4384 17 , , , cord-010092-uftc8inx 4384 18 available available JJ cord-010092-uftc8inx 4384 19 stock stock NN cord-010092-uftc8inx 4384 20 and and CC cord-010092-uftc8inx 4384 21 demand demand NN cord-010092-uftc8inx 4384 22 versus versus IN cord-010092-uftc8inx 4384 23 supply supply NN cord-010092-uftc8inx 4384 24 was be VBD cord-010092-uftc8inx 4384 25 determined determine VBN cord-010092-uftc8inx 4384 26 . . . cord-010092-uftc8inx 4385 1 Sub sub NN cord-010092-uftc8inx 4385 2 - - HYPH cord-010092-uftc8inx 4385 3 analysis analysis NN cord-010092-uftc8inx 4385 4 of of IN cord-010092-uftc8inx 4385 5 branches branch NNS cord-010092-uftc8inx 4385 6 was be VBD cord-010092-uftc8inx 4385 7 done do VBN cord-010092-uftc8inx 4385 8 to to TO cord-010092-uftc8inx 4385 9 determine determine VB cord-010092-uftc8inx 4385 10 individual individual JJ cord-010092-uftc8inx 4385 11 branch branch NN cord-010092-uftc8inx 4385 12 performance performance NN cord-010092-uftc8inx 4385 13 . . . cord-010092-uftc8inx 4386 1 Analysis analysis NN cord-010092-uftc8inx 4386 2 by by IN cord-010092-uftc8inx 4386 3 month month NN cord-010092-uftc8inx 4386 4 was be VBD cord-010092-uftc8inx 4386 5 done do VBN cord-010092-uftc8inx 4386 6 to to TO cord-010092-uftc8inx 4386 7 assess assess VB cord-010092-uftc8inx 4386 8 seasonal seasonal JJ cord-010092-uftc8inx 4386 9 variations variation NNS cord-010092-uftc8inx 4386 10 . . . cord-010092-uftc8inx 4387 1 Findings finding NNS cord-010092-uftc8inx 4387 2 and and CC cord-010092-uftc8inx 4387 3 recommendations recommendation NNS cord-010092-uftc8inx 4387 4 were be VBD cord-010092-uftc8inx 4387 5 shared share VBN cord-010092-uftc8inx 4387 6 among among IN cord-010092-uftc8inx 4387 7 key key JJ cord-010092-uftc8inx 4387 8 stakeholders stakeholder NNS cord-010092-uftc8inx 4387 9 to to TO cord-010092-uftc8inx 4387 10 validate validate VB cord-010092-uftc8inx 4387 11 the the DT cord-010092-uftc8inx 4387 12 BSMS BSMS NNP cord-010092-uftc8inx 4387 13 methodology methodology NN cord-010092-uftc8inx 4387 14 . . . cord-010092-uftc8inx 4388 1 Results result NNS cord-010092-uftc8inx 4388 2 : : : cord-010092-uftc8inx 4389 1 Overall overall RB cord-010092-uftc8inx 4389 2 the the DT cord-010092-uftc8inx 4389 3 quarantine quarantine NN cord-010092-uftc8inx 4389 4 stock stock NN cord-010092-uftc8inx 4389 5 average average NN cord-010092-uftc8inx 4389 6 was be VBD cord-010092-uftc8inx 4389 7 130.4 130.4 CD cord-010092-uftc8inx 4389 8 % % NN cord-010092-uftc8inx 4389 9 ( ( -LRB- cord-010092-uftc8inx 4389 10 SD sd NN cord-010092-uftc8inx 4389 11 + + CC cord-010092-uftc8inx 4389 12 /-101.6 /-101.6 NNS cord-010092-uftc8inx 4389 13 ) ) -RRB- cord-010092-uftc8inx 4389 14 , , , cord-010092-uftc8inx 4389 15 the the DT cord-010092-uftc8inx 4389 16 available available JJ cord-010092-uftc8inx 4389 17 stock stock NN cord-010092-uftc8inx 4389 18 was be VBD cord-010092-uftc8inx 4389 19 142.3 142.3 CD cord-010092-uftc8inx 4389 20 % % NN cord-010092-uftc8inx 4389 21 : : : cord-010092-uftc8inx 4390 1 ( ( -LRB- cord-010092-uftc8inx 4390 2 SD sd NN cord-010092-uftc8inx 4390 3 + + CC cord-010092-uftc8inx 4390 4 /-118.8 /-118.8 NN cord-010092-uftc8inx 4390 5 ) ) -RRB- cord-010092-uftc8inx 4390 6 and and CC cord-010092-uftc8inx 4391 1 the the DT cord-010092-uftc8inx 4391 2 demand demand NN cord-010092-uftc8inx 4391 3 versus versus IN cord-010092-uftc8inx 4391 4 supply supply NN cord-010092-uftc8inx 4391 5 was be VBD cord-010092-uftc8inx 4391 6 at at IN cord-010092-uftc8inx 4391 7 95.6 95.6 CD cord-010092-uftc8inx 4391 8 % % NN cord-010092-uftc8inx 4392 1 ( ( -LRB- cord-010092-uftc8inx 4392 2 SD SD NNP cord-010092-uftc8inx 4393 1 + + CC cord-010092-uftc8inx 4393 2 /-11.3).The /-11.3).The . cord-010092-uftc8inx 4393 3 overall overall JJ cord-010092-uftc8inx 4393 4 BSMS BSMS NNP cord-010092-uftc8inx 4393 5 was be VBD cord-010092-uftc8inx 4393 6 122.8 122.8 CD cord-010092-uftc8inx 4393 7 % % NN cord-010092-uftc8inx 4393 8 ; ; , cord-010092-uftc8inx 4393 9 ( ( -LRB- cord-010092-uftc8inx 4393 10 SD sd NN cord-010092-uftc8inx 4393 11 + + CC cord-010092-uftc8inx 4393 12 /-77.2 /-77.2 . cord-010092-uftc8inx 4393 13 ) ) -RRB- cord-010092-uftc8inx 4393 14 for for IN cord-010092-uftc8inx 4393 15 the the DT cord-010092-uftc8inx 4393 16 study study NN cord-010092-uftc8inx 4393 17 period period NN cord-010092-uftc8inx 4393 18 . . . cord-010092-uftc8inx 4394 1 Gweru Gweru NNP cord-010092-uftc8inx 4394 2 and and CC cord-010092-uftc8inx 4394 3 Masvingo Masvingo NNP cord-010092-uftc8inx 4394 4 nearly nearly RB cord-010092-uftc8inx 4394 5 supplied supply VBD cord-010092-uftc8inx 4394 6 all all PDT cord-010092-uftc8inx 4394 7 the the DT cord-010092-uftc8inx 4394 8 demanded demand VBN cord-010092-uftc8inx 4394 9 blood blood NN cord-010092-uftc8inx 4394 10 with with IN cord-010092-uftc8inx 4394 11 99.2 99.2 CD cord-010092-uftc8inx 4394 12 % % NN cord-010092-uftc8inx 4394 13 , , , cord-010092-uftc8inx 4394 14 overall overall JJ cord-010092-uftc8inx 4394 15 BSMS BSMS NNP cord-010092-uftc8inx 4394 16 of of IN cord-010092-uftc8inx 4394 17 118.1 118.1 CD cord-010092-uftc8inx 4394 18 % % NN cord-010092-uftc8inx 4394 19 and and CC cord-010092-uftc8inx 4394 20 99.7 99.7 CD cord-010092-uftc8inx 4394 21 % % NN cord-010092-uftc8inx 4394 22 , , , cord-010092-uftc8inx 4394 23 overall overall JJ cord-010092-uftc8inx 4394 24 BSMS BSMS NNP cord-010092-uftc8inx 4394 25 of of IN cord-010092-uftc8inx 4394 26 144.3 144.3 CD cord-010092-uftc8inx 4394 27 % % NN cord-010092-uftc8inx 4394 28 respectively respectively RB cord-010092-uftc8inx 4394 29 . . . cord-010092-uftc8inx 4395 1 Bulawayo Bulawayo NNP cord-010092-uftc8inx 4395 2 supplied supply VBD cord-010092-uftc8inx 4395 3 98.3 98.3 CD cord-010092-uftc8inx 4395 4 % % NN cord-010092-uftc8inx 4395 5 of of IN cord-010092-uftc8inx 4395 6 the the DT cord-010092-uftc8inx 4395 7 blood blood NN cord-010092-uftc8inx 4395 8 demanded demand VBD cord-010092-uftc8inx 4395 9 with with IN cord-010092-uftc8inx 4395 10 an an DT cord-010092-uftc8inx 4395 11 overall overall JJ cord-010092-uftc8inx 4395 12 BSMS BSMS NNP cord-010092-uftc8inx 4395 13 of of IN cord-010092-uftc8inx 4395 14 99.1 99.1 CD cord-010092-uftc8inx 4395 15 % % NN cord-010092-uftc8inx 4395 16 . . . cord-010092-uftc8inx 4396 1 Mutare Mutare NNP cord-010092-uftc8inx 4396 2 supplied supply VBD cord-010092-uftc8inx 4396 3 97.8 97.8 CD cord-010092-uftc8inx 4396 4 % % NN cord-010092-uftc8inx 4396 5 with with IN cord-010092-uftc8inx 4396 6 a a DT cord-010092-uftc8inx 4396 7 BSMS BSMS NNP cord-010092-uftc8inx 4396 8 of of IN cord-010092-uftc8inx 4396 9 180.1 180.1 CD cord-010092-uftc8inx 4396 10 % % NN cord-010092-uftc8inx 4396 11 and and CC cord-010092-uftc8inx 4396 12 Harare Harare NNP cord-010092-uftc8inx 4396 13 85.6 85.6 CD cord-010092-uftc8inx 4396 14 % % NN cord-010092-uftc8inx 4396 15 and and CC cord-010092-uftc8inx 4396 16 a a DT cord-010092-uftc8inx 4396 17 BSMS BSMS NNP cord-010092-uftc8inx 4396 18 of of IN cord-010092-uftc8inx 4396 19 78.0 78.0 CD cord-010092-uftc8inx 4396 20 % % NN cord-010092-uftc8inx 4396 21 . . . cord-010092-uftc8inx 4397 1 There there EX cord-010092-uftc8inx 4397 2 were be VBD cord-010092-uftc8inx 4397 3 monthly monthly JJ cord-010092-uftc8inx 4397 4 variations variation NNS cord-010092-uftc8inx 4397 5 but but CC cord-010092-uftc8inx 4397 6 the the DT cord-010092-uftc8inx 4397 7 Service Service NNP cord-010092-uftc8inx 4397 8 could could MD cord-010092-uftc8inx 4397 9 supply supply VB cord-010092-uftc8inx 4397 10 above above IN cord-010092-uftc8inx 4397 11 90 90 CD cord-010092-uftc8inx 4397 12 % % NN cord-010092-uftc8inx 4397 13 of of IN cord-010092-uftc8inx 4397 14 the the DT cord-010092-uftc8inx 4397 15 blood blood NN cord-010092-uftc8inx 4397 16 demand demand NN cord-010092-uftc8inx 4397 17 . . . cord-010092-uftc8inx 4398 1 In in IN cord-010092-uftc8inx 4398 2 the the DT cord-010092-uftc8inx 4398 3 Month Month NNP cord-010092-uftc8inx 4398 4 of of IN cord-010092-uftc8inx 4398 5 May May NNP cord-010092-uftc8inx 4398 6 the the DT cord-010092-uftc8inx 4398 7 Service Service NNP cord-010092-uftc8inx 4398 8 met meet VBD cord-010092-uftc8inx 4398 9 91.6 91.6 CD cord-010092-uftc8inx 4398 10 % % NN cord-010092-uftc8inx 4398 11 of of IN cord-010092-uftc8inx 4398 12 the the DT cord-010092-uftc8inx 4398 13 demand demand NN cord-010092-uftc8inx 4398 14 and and CC cord-010092-uftc8inx 4398 15 a a DT cord-010092-uftc8inx 4398 16 BSMS BSMS NNP cord-010092-uftc8inx 4398 17 of of IN cord-010092-uftc8inx 4398 18 87.8 87.8 CD cord-010092-uftc8inx 4398 19 % % NN cord-010092-uftc8inx 4398 20 . . . cord-010092-uftc8inx 4399 1 In in IN cord-010092-uftc8inx 4399 2 November November NNP cord-010092-uftc8inx 4399 3 and and CC cord-010092-uftc8inx 4399 4 December December NNP cord-010092-uftc8inx 4399 5 it -PRON- PRP cord-010092-uftc8inx 4399 6 supplied supply VBD cord-010092-uftc8inx 4399 7 92.6 92.6 CD cord-010092-uftc8inx 4399 8 % % NN cord-010092-uftc8inx 4399 9 , , , cord-010092-uftc8inx 4399 10 BSMS BSMS NNP cord-010092-uftc8inx 4399 11 of of IN cord-010092-uftc8inx 4399 12 100.8 100.8 CD cord-010092-uftc8inx 4399 13 % % NN cord-010092-uftc8inx 4399 14 and and CC cord-010092-uftc8inx 4399 15 92.8 92.8 CD cord-010092-uftc8inx 4399 16 % % NN cord-010092-uftc8inx 4399 17 , , , cord-010092-uftc8inx 4399 18 BSMS BSMS NNP cord-010092-uftc8inx 4399 19 131.8 131.8 CD cord-010092-uftc8inx 4399 20 % % NN cord-010092-uftc8inx 4399 21 respectively respectively RB cord-010092-uftc8inx 4399 22 . . . cord-010092-uftc8inx 4400 1 August August NNP cord-010092-uftc8inx 4400 2 also also RB cord-010092-uftc8inx 4400 3 had have VBD cord-010092-uftc8inx 4400 4 a a DT cord-010092-uftc8inx 4400 5 below below JJ cord-010092-uftc8inx 4400 6 average average JJ cord-010092-uftc8inx 4400 7 supply supply NN cord-010092-uftc8inx 4400 8 of of IN cord-010092-uftc8inx 4400 9 93 93 CD cord-010092-uftc8inx 4400 10 % % NN cord-010092-uftc8inx 4400 11 , , , cord-010092-uftc8inx 4400 12 BSMS BSMS NNP cord-010092-uftc8inx 4400 13 -98.2 -98.2 CD cord-010092-uftc8inx 4400 14 % % NN cord-010092-uftc8inx 4400 15 . . . cord-010092-uftc8inx 4401 1 June June NNP cord-010092-uftc8inx 4401 2 , , , cord-010092-uftc8inx 4401 3 October October NNP cord-010092-uftc8inx 4401 4 and and CC cord-010092-uftc8inx 4401 5 September September NNP cord-010092-uftc8inx 4401 6 recorded record VBD cord-010092-uftc8inx 4401 7 above above IN cord-010092-uftc8inx 4401 8 the the DT cord-010092-uftc8inx 4401 9 average average JJ cord-010092-uftc8inx 4401 10 values value NNS cord-010092-uftc8inx 4401 11 ; ; : cord-010092-uftc8inx 4401 12 97.3 97.3 CD cord-010092-uftc8inx 4401 13 % % NN cord-010092-uftc8inx 4401 14 , , , cord-010092-uftc8inx 4401 15 BSMS BSMS NNP cord-010092-uftc8inx 4401 16 of of IN cord-010092-uftc8inx 4401 17 126.8 126.8 CD cord-010092-uftc8inx 4401 18 % % NN cord-010092-uftc8inx 4401 19 and and CC cord-010092-uftc8inx 4401 20 98.7 98.7 CD cord-010092-uftc8inx 4401 21 % % NN cord-010092-uftc8inx 4401 22 , , , cord-010092-uftc8inx 4401 23 with with IN cord-010092-uftc8inx 4401 24 a a DT cord-010092-uftc8inx 4401 25 BSMS BSMS NNP cord-010092-uftc8inx 4401 26 of of IN cord-010092-uftc8inx 4401 27 117.2 117.2 CD cord-010092-uftc8inx 4401 28 % % NN cord-010092-uftc8inx 4401 29 respectively respectively RB cord-010092-uftc8inx 4401 30 . . . cord-010092-uftc8inx 4402 1 Summary Summary NNP cord-010092-uftc8inx 4402 2 / / SYM cord-010092-uftc8inx 4402 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 4402 4 : : : cord-010092-uftc8inx 4403 1 The the DT cord-010092-uftc8inx 4403 2 overall overall JJ cord-010092-uftc8inx 4403 3 BSMS BSMS NNP cord-010092-uftc8inx 4403 4 performance performance NN cord-010092-uftc8inx 4403 5 was be VBD cord-010092-uftc8inx 4403 6 satisfactory satisfactory JJ cord-010092-uftc8inx 4403 7 and and CC cord-010092-uftc8inx 4403 8 it -PRON- PRP cord-010092-uftc8inx 4403 9 was be VBD cord-010092-uftc8inx 4403 10 noted note VBN cord-010092-uftc8inx 4403 11 that that IN cord-010092-uftc8inx 4403 12 branches branch NNS cord-010092-uftc8inx 4403 13 capacitated capacitate VBN cord-010092-uftc8inx 4403 14 according accord VBG cord-010092-uftc8inx 4403 15 to to IN cord-010092-uftc8inx 4403 16 demand demand NN cord-010092-uftc8inx 4403 17 . . . cord-010092-uftc8inx 4404 1 The the DT cord-010092-uftc8inx 4404 2 new new JJ cord-010092-uftc8inx 4404 3 interactive interactive JJ cord-010092-uftc8inx 4404 4 analytics analytic NNS cord-010092-uftc8inx 4404 5 approach approach NN cord-010092-uftc8inx 4404 6 is be VBZ cord-010092-uftc8inx 4404 7 appropriate appropriate JJ cord-010092-uftc8inx 4404 8 for for IN cord-010092-uftc8inx 4404 9 showing show VBG cord-010092-uftc8inx 4404 10 the the DT cord-010092-uftc8inx 4404 11 blood blood NN cord-010092-uftc8inx 4404 12 bank bank NN cord-010092-uftc8inx 4404 13 status status NN cord-010092-uftc8inx 4404 14 and and CC cord-010092-uftc8inx 4404 15 assessing assess VBG cord-010092-uftc8inx 4404 16 the the DT cord-010092-uftc8inx 4404 17 performance performance NN cord-010092-uftc8inx 4404 18 of of IN cord-010092-uftc8inx 4404 19 the the DT cord-010092-uftc8inx 4404 20 branches branch NNS cord-010092-uftc8inx 4404 21 . . . cord-010092-uftc8inx 4405 1 This this DT cord-010092-uftc8inx 4405 2 new new JJ cord-010092-uftc8inx 4405 3 approach approach NN cord-010092-uftc8inx 4405 4 has have VBZ cord-010092-uftc8inx 4405 5 optimized optimize VBN cord-010092-uftc8inx 4405 6 the the DT cord-010092-uftc8inx 4405 7 decision decision NN cord-010092-uftc8inx 4405 8 - - HYPH cord-010092-uftc8inx 4405 9 making make VBG cord-010092-uftc8inx 4405 10 process process NN cord-010092-uftc8inx 4405 11 in in IN cord-010092-uftc8inx 4405 12 blood blood NN cord-010092-uftc8inx 4405 13 supply supply NN cord-010092-uftc8inx 4405 14 management management NN cord-010092-uftc8inx 4405 15 . . . cord-010092-uftc8inx 4406 1 The the DT cord-010092-uftc8inx 4406 2 metrics metric NNS cord-010092-uftc8inx 4406 3 are be VBP cord-010092-uftc8inx 4406 4 tracked track VBN cord-010092-uftc8inx 4406 5 using use VBG cord-010092-uftc8inx 4406 6 excel excel NNP cord-010092-uftc8inx 4406 7 based base VBN cord-010092-uftc8inx 4406 8 model model NN cord-010092-uftc8inx 4406 9 hence hence RB cord-010092-uftc8inx 4406 10 this this DT cord-010092-uftc8inx 4406 11 approach approach NN cord-010092-uftc8inx 4406 12 is be VBZ cord-010092-uftc8inx 4406 13 suitable suitable JJ cord-010092-uftc8inx 4406 14 for for IN cord-010092-uftc8inx 4406 15 resource resource NN cord-010092-uftc8inx 4406 16 constrained constrain VBN cord-010092-uftc8inx 4406 17 settings setting NNS cord-010092-uftc8inx 4406 18 with with IN cord-010092-uftc8inx 4406 19 limited limited JJ cord-010092-uftc8inx 4406 20 ICT ICT NNP cord-010092-uftc8inx 4406 21 infrastructure infrastructure NN cord-010092-uftc8inx 4406 22 . . . cord-010092-uftc8inx 4407 1 St St NNP cord-010092-uftc8inx 4407 2 Vincent Vincent NNP cord-010092-uftc8inx 4407 3 's 's POS cord-010092-uftc8inx 4407 4 Hospital Hospital NNP cord-010092-uftc8inx 4407 5 Melbourne Melbourne NNP cord-010092-uftc8inx 4407 6 ( ( -LRB- cord-010092-uftc8inx 4407 7 SVHM SVHM NNP cord-010092-uftc8inx 4407 8 ) ) -RRB- cord-010092-uftc8inx 4407 9 , , . cord-010092-uftc8inx 4408 1 a a DT cord-010092-uftc8inx 4408 2 tertiary tertiary JJ cord-010092-uftc8inx 4408 3 hospital hospital NN cord-010092-uftc8inx 4408 4 supporting support VBG cord-010092-uftc8inx 4408 5 medicine medicine NN cord-010092-uftc8inx 4408 6 , , , cord-010092-uftc8inx 4408 7 surgery surgery NN cord-010092-uftc8inx 4408 8 and and CC cord-010092-uftc8inx 4408 9 non non JJ cord-010092-uftc8inx 4408 10 - - JJ cord-010092-uftc8inx 4408 11 major major JJ cord-010092-uftc8inx 4408 12 trauma trauma NN cord-010092-uftc8inx 4408 13 emergency emergency NN cord-010092-uftc8inx 4408 14 and and CC cord-010092-uftc8inx 4408 15 ITU ITU NNP cord-010092-uftc8inx 4408 16 services service NNS cord-010092-uftc8inx 4408 17 implemented implement VBD cord-010092-uftc8inx 4408 18 a a DT cord-010092-uftc8inx 4408 19 MTP MTP NNP cord-010092-uftc8inx 4408 20 in in IN cord-010092-uftc8inx 4408 21 2008 2008 CD cord-010092-uftc8inx 4408 22 . . . cord-010092-uftc8inx 4409 1 Subsequent subsequent JJ cord-010092-uftc8inx 4409 2 MTP MTP NNP cord-010092-uftc8inx 4409 3 reassessment reassessment NN cord-010092-uftc8inx 4409 4 has have VBZ cord-010092-uftc8inx 4409 5 led lead VBN cord-010092-uftc8inx 4409 6 to to IN cord-010092-uftc8inx 4409 7 implementation implementation NN cord-010092-uftc8inx 4409 8 of of IN cord-010092-uftc8inx 4409 9 regular regular JJ cord-010092-uftc8inx 4409 10 multi multi JJ cord-010092-uftc8inx 4409 11 - - JJ cord-010092-uftc8inx 4409 12 disciplinary disciplinary JJ cord-010092-uftc8inx 4409 13 review review NN cord-010092-uftc8inx 4409 14 of of IN cord-010092-uftc8inx 4409 15 all all DT cord-010092-uftc8inx 4409 16 MTs mt NNS cord-010092-uftc8inx 4409 17 to to TO cord-010092-uftc8inx 4409 18 identify identify VB cord-010092-uftc8inx 4409 19 areas area NNS cord-010092-uftc8inx 4409 20 for for IN cord-010092-uftc8inx 4409 21 improvement improvement NN cord-010092-uftc8inx 4409 22 in in IN cord-010092-uftc8inx 4409 23 transfusion transfusion NN cord-010092-uftc8inx 4409 24 and and CC cord-010092-uftc8inx 4409 25 other other JJ cord-010092-uftc8inx 4409 26 aspects aspect NNS cord-010092-uftc8inx 4409 27 of of IN cord-010092-uftc8inx 4409 28 support support NN cord-010092-uftc8inx 4409 29 for for IN cord-010092-uftc8inx 4409 30 critically critically RB cord-010092-uftc8inx 4409 31 bleeding bleed VBG cord-010092-uftc8inx 4409 32 patients patient NNS cord-010092-uftc8inx 4409 33 . . . cord-010092-uftc8inx 4410 1 Aims aim VBZ cord-010092-uftc8inx 4410 2 : : : cord-010092-uftc8inx 4411 1 To to TO cord-010092-uftc8inx 4411 2 implement implement VB cord-010092-uftc8inx 4411 3 a a DT cord-010092-uftc8inx 4411 4 systematic systematic JJ cord-010092-uftc8inx 4411 5 service service NN cord-010092-uftc8inx 4411 6 - - HYPH cord-010092-uftc8inx 4411 7 wide wide JJ cord-010092-uftc8inx 4411 8 stakeholder stakeholder NN cord-010092-uftc8inx 4411 9 review review NN cord-010092-uftc8inx 4411 10 of of IN cord-010092-uftc8inx 4411 11 MT MT NNP cord-010092-uftc8inx 4411 12 events event NNS cord-010092-uftc8inx 4411 13 at at IN cord-010092-uftc8inx 4411 14 SVHM SVHM NNP cord-010092-uftc8inx 4411 15 aiming aim VBG cord-010092-uftc8inx 4411 16 to to TO cord-010092-uftc8inx 4411 17 identify identify VB cord-010092-uftc8inx 4411 18 deficiencies deficiency NNS cord-010092-uftc8inx 4411 19 and and CC cord-010092-uftc8inx 4411 20 implement implement VB cord-010092-uftc8inx 4411 21 improvements improvement NNS cord-010092-uftc8inx 4411 22 in in IN cord-010092-uftc8inx 4411 23 MT MT NNP cord-010092-uftc8inx 4411 24 management management NN cord-010092-uftc8inx 4411 25 . . . cord-010092-uftc8inx 4412 1 Methods method NNS cord-010092-uftc8inx 4412 2 : : : cord-010092-uftc8inx 4413 1 A a DT cord-010092-uftc8inx 4413 2 multi multi JJ cord-010092-uftc8inx 4413 3 - - JJ cord-010092-uftc8inx 4413 4 disciplinary disciplinary JJ cord-010092-uftc8inx 4413 5 MT MT NNP cord-010092-uftc8inx 4413 6 review review NN cord-010092-uftc8inx 4413 7 team team NN cord-010092-uftc8inx 4413 8 was be VBD cord-010092-uftc8inx 4413 9 established establish VBN cord-010092-uftc8inx 4413 10 as as IN cord-010092-uftc8inx 4413 11 a a DT cord-010092-uftc8inx 4413 12 subcommittee subcommittee NN cord-010092-uftc8inx 4413 13 of of IN cord-010092-uftc8inx 4413 14 the the DT cord-010092-uftc8inx 4413 15 hospital hospital NN cord-010092-uftc8inx 4413 16 Transfusion Transfusion NNP cord-010092-uftc8inx 4413 17 Committee Committee NNP cord-010092-uftc8inx 4413 18 ( ( -LRB- cord-010092-uftc8inx 4413 19 TC TC NNP cord-010092-uftc8inx 4413 20 ) ) -RRB- cord-010092-uftc8inx 4413 21 to to TO cord-010092-uftc8inx 4413 22 update update VB cord-010092-uftc8inx 4413 23 the the DT cord-010092-uftc8inx 4413 24 organisational organisational JJ cord-010092-uftc8inx 4413 25 MTP MTP NNP cord-010092-uftc8inx 4413 26 in in IN cord-010092-uftc8inx 4413 27 2016 2016 CD cord-010092-uftc8inx 4413 28 and and CC cord-010092-uftc8inx 4413 29 subsequently subsequently RB cord-010092-uftc8inx 4413 30 continued continue VBD cord-010092-uftc8inx 4413 31 to to TO cord-010092-uftc8inx 4413 32 meet meet VB cord-010092-uftc8inx 4413 33 quarterly quarterly RB cord-010092-uftc8inx 4413 34 as as IN cord-010092-uftc8inx 4413 35 the the DT cord-010092-uftc8inx 4413 36 MT MT NNP cord-010092-uftc8inx 4413 37 review review NN cord-010092-uftc8inx 4413 38 subcommittee subcommittee NN cord-010092-uftc8inx 4413 39 ( ( -LRB- cord-010092-uftc8inx 4413 40 MTRS MTRS NNP cord-010092-uftc8inx 4413 41 ) ) -RRB- cord-010092-uftc8inx 4413 42 of of IN cord-010092-uftc8inx 4413 43 the the DT cord-010092-uftc8inx 4413 44 TC TC NNP cord-010092-uftc8inx 4413 45 , , , cord-010092-uftc8inx 4413 46 systematically systematically RB cord-010092-uftc8inx 4413 47 reviewing review VBG cord-010092-uftc8inx 4413 48 all all DT cord-010092-uftc8inx 4413 49 aspects aspect NNS cord-010092-uftc8inx 4413 50 of of IN cord-010092-uftc8inx 4413 51 MTs MTs NNP cord-010092-uftc8inx 4413 52 at at IN cord-010092-uftc8inx 4413 53 SVHM SVHM NNP cord-010092-uftc8inx 4413 54 . . . cord-010092-uftc8inx 4414 1 Instances instance NNS cord-010092-uftc8inx 4414 2 where where WRB cord-010092-uftc8inx 4414 3 4 4 CD cord-010092-uftc8inx 4414 4 or or CC cord-010092-uftc8inx 4414 5 more more JJR cord-010092-uftc8inx 4414 6 red red JJ cord-010092-uftc8inx 4414 7 cell cell NN cord-010092-uftc8inx 4414 8 units unit NNS cord-010092-uftc8inx 4414 9 are be VBP cord-010092-uftc8inx 4414 10 transfused transfuse VBN cord-010092-uftc8inx 4414 11 in in IN cord-010092-uftc8inx 4414 12 < < NNP cord-010092-uftc8inx 4414 13 4 4 CD cord-010092-uftc8inx 4414 14 h h NNP cord-010092-uftc8inx 4414 15 are be VBP cord-010092-uftc8inx 4414 16 identified identify VBN cord-010092-uftc8inx 4414 17 from from IN cord-010092-uftc8inx 4414 18 the the DT cord-010092-uftc8inx 4414 19 laboratory laboratory NN cord-010092-uftc8inx 4414 20 information information NN cord-010092-uftc8inx 4414 21 system system NN cord-010092-uftc8inx 4414 22 and and CC cord-010092-uftc8inx 4414 23 reviewed review VBN cord-010092-uftc8inx 4414 24 by by IN cord-010092-uftc8inx 4414 25 the the DT cord-010092-uftc8inx 4414 26 MTRS MTRS NNP cord-010092-uftc8inx 4414 27 which which WDT cord-010092-uftc8inx 4414 28 includes include VBZ cord-010092-uftc8inx 4414 29 representatives representative NNS cord-010092-uftc8inx 4414 30 from from IN cord-010092-uftc8inx 4414 31 Accident Accident NNP cord-010092-uftc8inx 4414 32 and and CC cord-010092-uftc8inx 4414 33 Emergency Emergency NNP cord-010092-uftc8inx 4414 34 , , , cord-010092-uftc8inx 4414 35 Intensive Intensive NNP cord-010092-uftc8inx 4414 36 Care Care NNP cord-010092-uftc8inx 4414 37 , , , cord-010092-uftc8inx 4414 38 Operating Operating NNP cord-010092-uftc8inx 4414 39 Suite Suite NNP cord-010092-uftc8inx 4414 40 ( ( -LRB- cord-010092-uftc8inx 4414 41 OS OS NNP cord-010092-uftc8inx 4414 42 ) ) -RRB- cord-010092-uftc8inx 4414 43 and and CC cord-010092-uftc8inx 4414 44 Transfusion Transfusion NNP cord-010092-uftc8inx 4414 45 Laboratory Laboratory NNP cord-010092-uftc8inx 4414 46 staff staff NN cord-010092-uftc8inx 4414 47 ; ; : cord-010092-uftc8inx 4414 48 the the DT cord-010092-uftc8inx 4414 49 Head Head NNP cord-010092-uftc8inx 4414 50 of of IN cord-010092-uftc8inx 4414 51 the the DT cord-010092-uftc8inx 4414 52 patient patient NN cord-010092-uftc8inx 4414 53 's 's POS cord-010092-uftc8inx 4414 54 treating treat VBG cord-010092-uftc8inx 4414 55 unit unit NN cord-010092-uftc8inx 4414 56 is be VBZ cord-010092-uftc8inx 4414 57 also also RB cord-010092-uftc8inx 4414 58 invited invite VBN cord-010092-uftc8inx 4414 59 to to TO cord-010092-uftc8inx 4414 60 contribute contribute VB cord-010092-uftc8inx 4414 61 . . . cord-010092-uftc8inx 4415 1 Reviews review NNS cord-010092-uftc8inx 4415 2 include include VBP cord-010092-uftc8inx 4415 3 : : : cord-010092-uftc8inx 4415 4 demographics demographic NNS cord-010092-uftc8inx 4415 5 , , , cord-010092-uftc8inx 4415 6 clinical clinical JJ cord-010092-uftc8inx 4415 7 details detail NNS cord-010092-uftc8inx 4415 8 , , , cord-010092-uftc8inx 4415 9 comorbidities comorbiditie NNS cord-010092-uftc8inx 4415 10 , , , cord-010092-uftc8inx 4415 11 time time NN cord-010092-uftc8inx 4415 12 from from IN cord-010092-uftc8inx 4415 13 patient patient JJ cord-010092-uftc8inx 4415 14 arrival arrival NN cord-010092-uftc8inx 4415 15 to to TO cord-010092-uftc8inx 4415 16 pre pre JJ cord-010092-uftc8inx 4415 17 - - JJ cord-010092-uftc8inx 4415 18 transfusion transfusion JJ cord-010092-uftc8inx 4415 19 specimen specimen NN cord-010092-uftc8inx 4415 20 collection collection NN cord-010092-uftc8inx 4415 21 / / SYM cord-010092-uftc8inx 4415 22 receipt receipt NN cord-010092-uftc8inx 4415 23 , , , cord-010092-uftc8inx 4415 24 time time NN cord-010092-uftc8inx 4415 25 from from IN cord-010092-uftc8inx 4415 26 blood blood NN cord-010092-uftc8inx 4415 27 request request NN cord-010092-uftc8inx 4415 28 to to TO cord-010092-uftc8inx 4415 29 release release VB cord-010092-uftc8inx 4415 30 / / SYM cord-010092-uftc8inx 4415 31 transfusion transfusion NN cord-010092-uftc8inx 4415 32 , , , cord-010092-uftc8inx 4415 33 regularity regularity NN cord-010092-uftc8inx 4415 34 of of IN cord-010092-uftc8inx 4415 35 full full JJ cord-010092-uftc8inx 4415 36 blood blood NN cord-010092-uftc8inx 4415 37 examination examination NN cord-010092-uftc8inx 4415 38 ( ( -LRB- cord-010092-uftc8inx 4415 39 FBE)/coagulation FBE)/coagulation NNP cord-010092-uftc8inx 4415 40 ( ( -LRB- cord-010092-uftc8inx 4415 41 coag coag NN cord-010092-uftc8inx 4415 42 ) ) -RRB- cord-010092-uftc8inx 4415 43 testing testing NN cord-010092-uftc8inx 4415 44 , , , cord-010092-uftc8inx 4415 45 timing timing NN cord-010092-uftc8inx 4415 46 of of IN cord-010092-uftc8inx 4415 47 blood blood NN cord-010092-uftc8inx 4415 48 component component NN cord-010092-uftc8inx 4415 49 transfusion transfusion NN cord-010092-uftc8inx 4415 50 , , , cord-010092-uftc8inx 4415 51 total total JJ cord-010092-uftc8inx 4415 52 component component NN cord-010092-uftc8inx 4415 53 provision provision NN cord-010092-uftc8inx 4415 54 / / SYM cord-010092-uftc8inx 4415 55 ratios ratio NNS cord-010092-uftc8inx 4415 56 , , , cord-010092-uftc8inx 4415 57 component component NN cord-010092-uftc8inx 4415 58 waste waste NN cord-010092-uftc8inx 4415 59 , , , cord-010092-uftc8inx 4415 60 patient patient JJ cord-010092-uftc8inx 4415 61 outcome outcome NN cord-010092-uftc8inx 4415 62 , , , cord-010092-uftc8inx 4415 63 and and CC cord-010092-uftc8inx 4415 64 communication communication NN cord-010092-uftc8inx 4415 65 between between IN cord-010092-uftc8inx 4415 66 various various JJ cord-010092-uftc8inx 4415 67 clinical clinical JJ cord-010092-uftc8inx 4415 68 areas area NNS cord-010092-uftc8inx 4415 69 and and CC cord-010092-uftc8inx 4415 70 also also RB cord-010092-uftc8inx 4415 71 the the DT cord-010092-uftc8inx 4415 72 laboratory laboratory NN cord-010092-uftc8inx 4415 73 . . . cord-010092-uftc8inx 4416 1 A a DT cord-010092-uftc8inx 4416 2 discussion discussion NN cord-010092-uftc8inx 4416 3 summary summary NN cord-010092-uftc8inx 4416 4 with with IN cord-010092-uftc8inx 4416 5 actions/ actions/ NNP cord-010092-uftc8inx 4416 6 recommendations recommendation NNS cord-010092-uftc8inx 4416 7 is be VBZ cord-010092-uftc8inx 4416 8 provided provide VBN cord-010092-uftc8inx 4416 9 to to IN cord-010092-uftc8inx 4416 10 the the DT cord-010092-uftc8inx 4416 11 TC TC NNP cord-010092-uftc8inx 4416 12 and and CC cord-010092-uftc8inx 4416 13 some some DT cord-010092-uftc8inx 4416 14 cases case NNS cord-010092-uftc8inx 4416 15 referred refer VBN cord-010092-uftc8inx 4416 16 to to IN cord-010092-uftc8inx 4416 17 the the DT cord-010092-uftc8inx 4416 18 hospital hospital NN cord-010092-uftc8inx 4416 19 Mortality Mortality NNP cord-010092-uftc8inx 4416 20 / / SYM cord-010092-uftc8inx 4416 21 Clinical Clinical NNP cord-010092-uftc8inx 4416 22 Review Review NNP cord-010092-uftc8inx 4416 23 Committee Committee NNP cord-010092-uftc8inx 4416 24 . . . cord-010092-uftc8inx 4417 1 Results result NNS cord-010092-uftc8inx 4417 2 : : : cord-010092-uftc8inx 4417 3 Cases case NNS cord-010092-uftc8inx 4417 4 reviewed review VBD cord-010092-uftc8inx 4417 5 : : : cord-010092-uftc8inx 4417 6 65 65 CD cord-010092-uftc8inx 4417 7 from from IN cord-010092-uftc8inx 4417 8 10 10 CD cord-010092-uftc8inx 4417 9 treating treat VBG cord-010092-uftc8inx 4417 10 units unit NNS cord-010092-uftc8inx 4417 11 including include VBG cord-010092-uftc8inx 4417 12 Cardiothoracic cardiothoracic JJ cord-010092-uftc8inx 4417 13 surgery surgery NN cord-010092-uftc8inx 4417 14 ( ( -LRB- cord-010092-uftc8inx 4417 15 18 18 CD cord-010092-uftc8inx 4417 16 ) ) -RRB- cord-010092-uftc8inx 4418 1 Hepatobiliary Hepatobiliary NNP cord-010092-uftc8inx 4418 2 / / SYM cord-010092-uftc8inx 4418 3 Gastrointestinal Gastrointestinal NNP cord-010092-uftc8inx 4418 4 / / SYM cord-010092-uftc8inx 4418 5 Colorectal Colorectal NNP cord-010092-uftc8inx 4418 6 surgery surgery NN cord-010092-uftc8inx 4418 7 ( ( -LRB- cord-010092-uftc8inx 4418 8 24 24 CD cord-010092-uftc8inx 4418 9 ) ) -RRB- cord-010092-uftc8inx 4418 10 , , , cord-010092-uftc8inx 4418 11 Vascular vascular JJ cord-010092-uftc8inx 4418 12 surgery surgery NN cord-010092-uftc8inx 4418 13 ( ( -LRB- cord-010092-uftc8inx 4418 14 6 6 CD cord-010092-uftc8inx 4418 15 ) ) -RRB- cord-010092-uftc8inx 4418 16 , , , cord-010092-uftc8inx 4418 17 Neurosurgery Neurosurgery NNP cord-010092-uftc8inx 4418 18 ( ( -LRB- cord-010092-uftc8inx 4418 19 4 4 CD cord-010092-uftc8inx 4418 20 ) ) -RRB- cord-010092-uftc8inx 4418 21 , , , cord-010092-uftc8inx 4418 22 Orthopaedic Orthopaedic NNP cord-010092-uftc8inx 4418 23 surgery surgery NN cord-010092-uftc8inx 4418 24 ( ( -LRB- cord-010092-uftc8inx 4418 25 3 3 CD cord-010092-uftc8inx 4418 26 ) ) -RRB- cord-010092-uftc8inx 4418 27 , , , cord-010092-uftc8inx 4418 28 Endocrine endocrine NN cord-010092-uftc8inx 4418 29 ( ( -LRB- cord-010092-uftc8inx 4418 30 2 2 CD cord-010092-uftc8inx 4418 31 ) ) -RRB- cord-010092-uftc8inx 4418 32 and and CC cord-010092-uftc8inx 4418 33 " " `` cord-010092-uftc8inx 4418 34 other other JJ cord-010092-uftc8inx 4418 35 " " '' cord-010092-uftc8inx 4418 36 ( ( -LRB- cord-010092-uftc8inx 4418 37 encompassing encompass VBG cord-010092-uftc8inx 4418 38 General General NNP cord-010092-uftc8inx 4418 39 Surgery Surgery NNP cord-010092-uftc8inx 4418 40 , , , cord-010092-uftc8inx 4418 41 Urology Urology NNP cord-010092-uftc8inx 4418 42 , , , cord-010092-uftc8inx 4418 43 General General NNP cord-010092-uftc8inx 4418 44 Medicine Medicine NNP cord-010092-uftc8inx 4418 45 and and CC cord-010092-uftc8inx 4418 46 Oncology Oncology NNP cord-010092-uftc8inx 4418 47 -8 -8 NNP cord-010092-uftc8inx 4418 48 ) ) -RRB- cord-010092-uftc8inx 4418 49 . . . cord-010092-uftc8inx 4419 1 Areas area NNS cord-010092-uftc8inx 4419 2 for for IN cord-010092-uftc8inx 4419 3 monitoring monitor VBG cord-010092-uftc8inx 4419 4 / / SYM cord-010092-uftc8inx 4419 5 improvement improvement NN cord-010092-uftc8inx 4419 6 identified identify VBN cord-010092-uftc8inx 4419 7 : : : cord-010092-uftc8inx 4419 8 transfusion transfusion NN cord-010092-uftc8inx 4419 9 documentation documentation NN cord-010092-uftc8inx 4419 10 , , , cord-010092-uftc8inx 4419 11 regularity regularity NN cord-010092-uftc8inx 4419 12 of of IN cord-010092-uftc8inx 4419 13 FBE FBE NNP cord-010092-uftc8inx 4419 14 / / SYM cord-010092-uftc8inx 4419 15 coag coag NN cord-010092-uftc8inx 4419 16 specimen specimen NN cord-010092-uftc8inx 4419 17 submission submission NN cord-010092-uftc8inx 4419 18 , , , cord-010092-uftc8inx 4419 19 reducing reduce VBG cord-010092-uftc8inx 4419 20 time time NN cord-010092-uftc8inx 4419 21 between between IN cord-010092-uftc8inx 4419 22 patient patient JJ cord-010092-uftc8inx 4419 23 arrival arrival NN cord-010092-uftc8inx 4419 24 and and CC cord-010092-uftc8inx 4419 25 specimen specimen NN cord-010092-uftc8inx 4419 26 collection collection NN cord-010092-uftc8inx 4419 27 , , , cord-010092-uftc8inx 4419 28 reducing reduce VBG cord-010092-uftc8inx 4419 29 specimen specimen JJ cord-010092-uftc8inx 4419 30 transport transport NN cord-010092-uftc8inx 4419 31 time time NN cord-010092-uftc8inx 4419 32 , , , cord-010092-uftc8inx 4419 33 interfacing interface VBG cord-010092-uftc8inx 4419 34 point point NN cord-010092-uftc8inx 4419 35 of of IN cord-010092-uftc8inx 4419 36 care care NN cord-010092-uftc8inx 4419 37 bloodgas bloodgas NN cord-010092-uftc8inx 4419 38 analysers analyser NNS cord-010092-uftc8inx 4419 39 to to IN cord-010092-uftc8inx 4419 40 the the DT cord-010092-uftc8inx 4419 41 central central JJ cord-010092-uftc8inx 4419 42 pathology pathology NN cord-010092-uftc8inx 4419 43 result result NN cord-010092-uftc8inx 4419 44 management management NN cord-010092-uftc8inx 4419 45 system system NN cord-010092-uftc8inx 4419 46 as as RB cord-010092-uftc8inx 4419 47 well well RB cord-010092-uftc8inx 4419 48 as as IN cord-010092-uftc8inx 4419 49 component component NN cord-010092-uftc8inx 4419 50 management management NN cord-010092-uftc8inx 4419 51 / / SYM cord-010092-uftc8inx 4419 52 waste waste NN cord-010092-uftc8inx 4419 53 reduction reduction NN cord-010092-uftc8inx 4419 54 and and CC cord-010092-uftc8inx 4419 55 the the DT cord-010092-uftc8inx 4419 56 introduction introduction NN cord-010092-uftc8inx 4419 57 of of IN cord-010092-uftc8inx 4419 58 viscoelastometry viscoelastometry NN cord-010092-uftc8inx 4419 59 assessment assessment NN cord-010092-uftc8inx 4419 60 in in IN cord-010092-uftc8inx 4419 61 the the DT cord-010092-uftc8inx 4419 62 OS os NN cord-010092-uftc8inx 4419 63 . . . cord-010092-uftc8inx 4420 1 18 18 CD cord-010092-uftc8inx 4420 2 of of IN cord-010092-uftc8inx 4420 3 65 65 CD cord-010092-uftc8inx 4420 4 reviewed review VBN cord-010092-uftc8inx 4420 5 cases case NNS cord-010092-uftc8inx 4420 6 involved involve VBD cord-010092-uftc8inx 4420 7 the the DT cord-010092-uftc8inx 4420 8 transfusion transfusion NN cord-010092-uftc8inx 4420 9 of of IN cord-010092-uftc8inx 4420 10 emergency emergency NN cord-010092-uftc8inx 4420 11 uncrossmatched uncrossmatched JJ cord-010092-uftc8inx 4420 12 O o UH cord-010092-uftc8inx 4420 13 RhD rhd NN cord-010092-uftc8inx 4420 14 negative negative JJ cord-010092-uftc8inx 4420 15 red red JJ cord-010092-uftc8inx 4420 16 cell cell NN cord-010092-uftc8inx 4420 17 units unit NNS cord-010092-uftc8inx 4420 18 . . . cord-010092-uftc8inx 4421 1 The the DT cord-010092-uftc8inx 4421 2 appropriateness appropriateness NN cord-010092-uftc8inx 4421 3 of of IN cord-010092-uftc8inx 4421 4 the the DT cord-010092-uftc8inx 4421 5 use use NN cord-010092-uftc8inx 4421 6 of of IN cord-010092-uftc8inx 4421 7 this this DT cord-010092-uftc8inx 4421 8 precious precious JJ cord-010092-uftc8inx 4421 9 resource resource NN cord-010092-uftc8inx 4421 10 is be VBZ cord-010092-uftc8inx 4421 11 also also RB cord-010092-uftc8inx 4421 12 reviewed review VBN cord-010092-uftc8inx 4421 13 by by IN cord-010092-uftc8inx 4421 14 the the DT cord-010092-uftc8inx 4421 15 MTRS MTRS NNP cord-010092-uftc8inx 4421 16 . . . cord-010092-uftc8inx 4422 1 Summary Summary NNP cord-010092-uftc8inx 4422 2 / / SYM cord-010092-uftc8inx 4422 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 4422 4 : : : cord-010092-uftc8inx 4423 1 The the DT cord-010092-uftc8inx 4423 2 SVHM SVHM NNP cord-010092-uftc8inx 4423 3 MTRS MTRS NNP cord-010092-uftc8inx 4423 4 meets meet VBZ cord-010092-uftc8inx 4423 5 regularly regularly RB cord-010092-uftc8inx 4423 6 to to TO cord-010092-uftc8inx 4423 7 review review VB cord-010092-uftc8inx 4423 8 MT MT NNP cord-010092-uftc8inx 4423 9 events event NNS cord-010092-uftc8inx 4423 10 and and CC cord-010092-uftc8inx 4423 11 formalise formalise VB cord-010092-uftc8inx 4423 12 multidisciplinary multidisciplinary JJ cord-010092-uftc8inx 4423 13 collaboration collaboration NN cord-010092-uftc8inx 4423 14 in in IN cord-010092-uftc8inx 4423 15 identifying identify VBG cord-010092-uftc8inx 4423 16 possible possible JJ cord-010092-uftc8inx 4423 17 improvements improvement NNS cord-010092-uftc8inx 4423 18 to to TO cord-010092-uftc8inx 4423 19 support support VB cord-010092-uftc8inx 4423 20 these these DT cord-010092-uftc8inx 4423 21 often often RB cord-010092-uftc8inx 4423 22 critically critically RB cord-010092-uftc8inx 4423 23 ill ill JJ cord-010092-uftc8inx 4423 24 patients patient NNS cord-010092-uftc8inx 4423 25 . . . cord-010092-uftc8inx 4424 1 Matters matter NNS cord-010092-uftc8inx 4424 2 highlighted highlight VBN cord-010092-uftc8inx 4424 3 include include VBP cord-010092-uftc8inx 4424 4 communication communication NN cord-010092-uftc8inx 4424 5 issues issue NNS cord-010092-uftc8inx 4424 6 , , , cord-010092-uftc8inx 4424 7 delays delay NNS cord-010092-uftc8inx 4424 8 in in IN cord-010092-uftc8inx 4424 9 specimen specimen JJ cord-010092-uftc8inx 4424 10 delivery delivery NN cord-010092-uftc8inx 4424 11 and and CC cord-010092-uftc8inx 4424 12 blood blood NN cord-010092-uftc8inx 4424 13 component component NN cord-010092-uftc8inx 4424 14 waste waste NN cord-010092-uftc8inx 4424 15 minimisation minimisation NN cord-010092-uftc8inx 4424 16 . . . cord-010092-uftc8inx 4425 1 Areas area NNS cord-010092-uftc8inx 4425 2 for for IN cord-010092-uftc8inx 4425 3 further further JJ cord-010092-uftc8inx 4425 4 work work NN cord-010092-uftc8inx 4425 5 include include VBP cord-010092-uftc8inx 4425 6 minimising minimise VBG cord-010092-uftc8inx 4425 7 delay delay NN cord-010092-uftc8inx 4425 8 between between IN cord-010092-uftc8inx 4425 9 MT MT NNP cord-010092-uftc8inx 4425 10 events event NNS cord-010092-uftc8inx 4425 11 and and CC cord-010092-uftc8inx 4425 12 review review NN cord-010092-uftc8inx 4425 13 , , , cord-010092-uftc8inx 4425 14 and and CC cord-010092-uftc8inx 4425 15 formalisation formalisation NN cord-010092-uftc8inx 4425 16 of of IN cord-010092-uftc8inx 4425 17 key key JJ cord-010092-uftc8inx 4425 18 performance performance NN cord-010092-uftc8inx 4425 19 indicators indicator NNS cord-010092-uftc8inx 4425 20 for for IN cord-010092-uftc8inx 4425 21 MTs MTs NNP cord-010092-uftc8inx 4425 22 . . . cord-010092-uftc8inx 4426 1 Background background NN cord-010092-uftc8inx 4426 2 : : : cord-010092-uftc8inx 4427 1 The the DT cord-010092-uftc8inx 4427 2 use use NN cord-010092-uftc8inx 4427 3 of of IN cord-010092-uftc8inx 4427 4 Radio Radio NNP cord-010092-uftc8inx 4427 5 Frequency Frequency NNP cord-010092-uftc8inx 4427 6 Identification Identification NNP cord-010092-uftc8inx 4427 7 ( ( -LRB- cord-010092-uftc8inx 4427 8 RFID RFID NNP cord-010092-uftc8inx 4427 9 ) ) -RRB- cord-010092-uftc8inx 4427 10 technology technology NN cord-010092-uftc8inx 4427 11 to to TO cord-010092-uftc8inx 4427 12 manage manage VB cord-010092-uftc8inx 4427 13 the the DT cord-010092-uftc8inx 4427 14 blood blood NN cord-010092-uftc8inx 4427 15 supply supply NN cord-010092-uftc8inx 4427 16 chain chain NN cord-010092-uftc8inx 4427 17 is be VBZ cord-010092-uftc8inx 4427 18 recognized recognize VBN cord-010092-uftc8inx 4427 19 as as IN cord-010092-uftc8inx 4427 20 a a DT cord-010092-uftc8inx 4427 21 major major JJ cord-010092-uftc8inx 4427 22 enhancement enhancement NN cord-010092-uftc8inx 4427 23 to to IN cord-010092-uftc8inx 4427 24 the the DT cord-010092-uftc8inx 4427 25 operations operation NNS cord-010092-uftc8inx 4427 26 of of IN cord-010092-uftc8inx 4427 27 Blood Blood NNP cord-010092-uftc8inx 4427 28 Banks Banks NNPS cord-010092-uftc8inx 4427 29 and and CC cord-010092-uftc8inx 4427 30 Hospital Hospital NNP cord-010092-uftc8inx 4427 31 Transfusion Transfusion NNP cord-010092-uftc8inx 4427 32 services service NNS cord-010092-uftc8inx 4427 33 . . . cord-010092-uftc8inx 4428 1 To to TO cord-010092-uftc8inx 4428 2 facilitate facilitate VB cord-010092-uftc8inx 4428 3 optimal optimal JJ cord-010092-uftc8inx 4428 4 blood blood NN cord-010092-uftc8inx 4428 5 supply supply NN cord-010092-uftc8inx 4428 6 management management NN cord-010092-uftc8inx 4428 7 , , , cord-010092-uftc8inx 4428 8 it -PRON- PRP cord-010092-uftc8inx 4428 9 is be VBZ cord-010092-uftc8inx 4428 10 crucial crucial JJ cord-010092-uftc8inx 4428 11 to to TO cord-010092-uftc8inx 4428 12 guarantee guarantee VB cord-010092-uftc8inx 4428 13 the the DT cord-010092-uftc8inx 4428 14 integrity integrity NN cord-010092-uftc8inx 4428 15 of of IN cord-010092-uftc8inx 4428 16 RFID RFID NNP cord-010092-uftc8inx 4428 17 tags tag NNS cord-010092-uftc8inx 4428 18 throughout throughout IN cord-010092-uftc8inx 4428 19 the the DT cord-010092-uftc8inx 4428 20 transfusion transfusion NN cord-010092-uftc8inx 4428 21 chain chain NN cord-010092-uftc8inx 4428 22 . . . cord-010092-uftc8inx 4429 1 Since since IN cord-010092-uftc8inx 4429 2 RFID RFID NNP cord-010092-uftc8inx 4429 3 tags tag NNS cord-010092-uftc8inx 4429 4 can can MD cord-010092-uftc8inx 4429 5 be be VB cord-010092-uftc8inx 4429 6 affixed affix VBN cord-010092-uftc8inx 4429 7 to to IN cord-010092-uftc8inx 4429 8 blood blood NN cord-010092-uftc8inx 4429 9 products product NNS cord-010092-uftc8inx 4429 10 very very RB cord-010092-uftc8inx 4429 11 early early RB cord-010092-uftc8inx 4429 12 in in IN cord-010092-uftc8inx 4429 13 the the DT cord-010092-uftc8inx 4429 14 process process NN cord-010092-uftc8inx 4429 15 , , , cord-010092-uftc8inx 4429 16 these these DT cord-010092-uftc8inx 4429 17 tags tag NNS cord-010092-uftc8inx 4429 18 undergo undergo VBP cord-010092-uftc8inx 4429 19 the the DT cord-010092-uftc8inx 4429 20 same same JJ cord-010092-uftc8inx 4429 21 process process NN cord-010092-uftc8inx 4429 22 - - HYPH cord-010092-uftc8inx 4429 23 steps step NNS cord-010092-uftc8inx 4429 24 as as IN cord-010092-uftc8inx 4429 25 the the DT cord-010092-uftc8inx 4429 26 blood blood NN cord-010092-uftc8inx 4429 27 products product NNS cord-010092-uftc8inx 4429 28 themselves -PRON- PRP cord-010092-uftc8inx 4429 29 ( ( -LRB- cord-010092-uftc8inx 4429 30 e.g. e.g. RB cord-010092-uftc8inx 4429 31 centrifugation centrifugation NN cord-010092-uftc8inx 4429 32 , , , cord-010092-uftc8inx 4429 33 label label NN cord-010092-uftc8inx 4429 34 printing printing NN cord-010092-uftc8inx 4429 35 , , , cord-010092-uftc8inx 4429 36 shock shock NN cord-010092-uftc8inx 4429 37 - - HYPH cord-010092-uftc8inx 4429 38 freezing freezing NN cord-010092-uftc8inx 4429 39 and and CC cord-010092-uftc8inx 4429 40 irradiation irradiation NN cord-010092-uftc8inx 4429 41 ) ) -RRB- cord-010092-uftc8inx 4429 42 . . . cord-010092-uftc8inx 4430 1 Aims aim VBZ cord-010092-uftc8inx 4430 2 : : : cord-010092-uftc8inx 4431 1 The the DT cord-010092-uftc8inx 4431 2 goal goal NN cord-010092-uftc8inx 4431 3 of of IN cord-010092-uftc8inx 4431 4 this this DT cord-010092-uftc8inx 4431 5 study study NN cord-010092-uftc8inx 4431 6 was be VBD cord-010092-uftc8inx 4431 7 to to TO cord-010092-uftc8inx 4431 8 validate validate VB cord-010092-uftc8inx 4431 9 the the DT cord-010092-uftc8inx 4431 10 mechanical mechanical JJ cord-010092-uftc8inx 4431 11 and and CC cord-010092-uftc8inx 4431 12 functional functional JJ cord-010092-uftc8inx 4431 13 resistance resistance NN cord-010092-uftc8inx 4431 14 of of IN cord-010092-uftc8inx 4431 15 Biolog Biolog NNP cord-010092-uftc8inx 4431 16 - - HYPH cord-010092-uftc8inx 4431 17 id id NNP cord-010092-uftc8inx 4431 18 RFID RFID NNP cord-010092-uftc8inx 4431 19 tags tag NNS cord-010092-uftc8inx 4431 20 through through IN cord-010092-uftc8inx 4431 21 different different JJ cord-010092-uftc8inx 4431 22 blood blood NN cord-010092-uftc8inx 4431 23 related relate VBN cord-010092-uftc8inx 4431 24 processes process NNS cord-010092-uftc8inx 4431 25 : : : cord-010092-uftc8inx 4431 26 centrifugation centrifugation NN cord-010092-uftc8inx 4431 27 , , , cord-010092-uftc8inx 4431 28 label label NN cord-010092-uftc8inx 4431 29 printing printing NN cord-010092-uftc8inx 4431 30 , , , cord-010092-uftc8inx 4431 31 shock shock NN cord-010092-uftc8inx 4431 32 - - HYPH cord-010092-uftc8inx 4431 33 freezing freeze VBG cord-010092-uftc8inx 4431 34 , , , cord-010092-uftc8inx 4431 35 intensive intensive JJ cord-010092-uftc8inx 4431 36 reading reading NN cord-010092-uftc8inx 4431 37 at at IN cord-010092-uftc8inx 4431 38 À40 À40 NNP cord-010092-uftc8inx 4431 39 ° ° NN cord-010092-uftc8inx 4431 40 C c NN cord-010092-uftc8inx 4431 41 , , , cord-010092-uftc8inx 4431 42 and and CC cord-010092-uftc8inx 4431 43 irradiation irradiation NN cord-010092-uftc8inx 4431 44 . . . cord-010092-uftc8inx 4432 1 Biolog Biolog NNP cord-010092-uftc8inx 4432 2 - - HYPH cord-010092-uftc8inx 4432 3 id id NNP cord-010092-uftc8inx 4432 4 tags tag NNS cord-010092-uftc8inx 4432 5 are be VBP cord-010092-uftc8inx 4432 6 passive passive JJ cord-010092-uftc8inx 4432 7 HF HF NNP cord-010092-uftc8inx 4432 8 ( ( -LRB- cord-010092-uftc8inx 4432 9 13.56 13.56 CD cord-010092-uftc8inx 4432 10 MHz MHz NNPS cord-010092-uftc8inx 4432 11 ) ) -RRB- cord-010092-uftc8inx 4432 12 tags tag NNS cord-010092-uftc8inx 4432 13 . . . cord-010092-uftc8inx 4433 1 They -PRON- PRP cord-010092-uftc8inx 4433 2 are be VBP cord-010092-uftc8inx 4433 3 compliant compliant JJ cord-010092-uftc8inx 4433 4 with with IN cord-010092-uftc8inx 4433 5 IS0 IS0 NNP cord-010092-uftc8inx 4433 6 15693 15693 CD cord-010092-uftc8inx 4433 7 , , , cord-010092-uftc8inx 4433 8 ISO iso NN cord-010092-uftc8inx 4433 9 18000 18000 CD cord-010092-uftc8inx 4433 10 - - SYM cord-010092-uftc8inx 4433 11 3 3 CD cord-010092-uftc8inx 4433 12 and and CC cord-010092-uftc8inx 4433 13 follow follow VB cord-010092-uftc8inx 4433 14 the the DT cord-010092-uftc8inx 4433 15 Guidelines Guidelines NNPS cord-010092-uftc8inx 4433 16 for for IN cord-010092-uftc8inx 4433 17 the the DT cord-010092-uftc8inx 4433 18 Use Use NNP cord-010092-uftc8inx 4433 19 of of IN cord-010092-uftc8inx 4433 20 RFID RFID NNP cord-010092-uftc8inx 4433 21 Technology Technology NNP cord-010092-uftc8inx 4433 22 in in IN cord-010092-uftc8inx 4433 23 Transfusion Transfusion NNP cord-010092-uftc8inx 4433 24 Medicine Medicine NNP cord-010092-uftc8inx 4433 25 ( ( -LRB- cord-010092-uftc8inx 4433 26 Vox Vox NNP cord-010092-uftc8inx 4433 27 Sanguinis Sanguinis NNP cord-010092-uftc8inx 4433 28 , , , cord-010092-uftc8inx 4433 29 2010 2010 CD cord-010092-uftc8inx 4433 30 ) ) -RRB- cord-010092-uftc8inx 4433 31 . . . cord-010092-uftc8inx 4434 1 Methods method NNS cord-010092-uftc8inx 4434 2 : : : cord-010092-uftc8inx 4434 3 Biolog Biolog NNP cord-010092-uftc8inx 4434 4 - - HYPH cord-010092-uftc8inx 4434 5 id id NNP cord-010092-uftc8inx 4434 6 tags tag NNS cord-010092-uftc8inx 4434 7 were be VBD cord-010092-uftc8inx 4434 8 evaluated evaluate VBN cord-010092-uftc8inx 4434 9 using use VBG cord-010092-uftc8inx 4434 10 a a DT cord-010092-uftc8inx 4434 11 series series NN cord-010092-uftc8inx 4434 12 of of IN cord-010092-uftc8inx 4434 13 RFID RFID NNP cord-010092-uftc8inx 4434 14 encoding encoding NN cord-010092-uftc8inx 4434 15 and and CC cord-010092-uftc8inx 4434 16 reading reading NN cord-010092-uftc8inx 4434 17 tests test NNS cord-010092-uftc8inx 4434 18 . . . cord-010092-uftc8inx 4435 1 Before before IN cord-010092-uftc8inx 4435 2 each each DT cord-010092-uftc8inx 4435 3 of of IN cord-010092-uftc8inx 4435 4 the the DT cord-010092-uftc8inx 4435 5 processing processing NN cord-010092-uftc8inx 4435 6 steps step NNS cord-010092-uftc8inx 4435 7 , , , cord-010092-uftc8inx 4435 8 each each DT cord-010092-uftc8inx 4435 9 tag tag NN cord-010092-uftc8inx 4435 10 was be VBD cord-010092-uftc8inx 4435 11 encoded encode VBN cord-010092-uftc8inx 4435 12 with with IN cord-010092-uftc8inx 4435 13 Donation Donation NNP cord-010092-uftc8inx 4435 14 Number Number NNP cord-010092-uftc8inx 4435 15 , , , cord-010092-uftc8inx 4435 16 Site Site NNP cord-010092-uftc8inx 4435 17 ID ID NNP cord-010092-uftc8inx 4435 18 , , , cord-010092-uftc8inx 4435 19 Product Product NNP cord-010092-uftc8inx 4435 20 Code Code NNP cord-010092-uftc8inx 4435 21 , , , cord-010092-uftc8inx 4435 22 Blood Blood NNP cord-010092-uftc8inx 4435 23 Group Group NNP cord-010092-uftc8inx 4435 24 and and CC cord-010092-uftc8inx 4435 25 Expiry Expiry NNP cord-010092-uftc8inx 4435 26 Date Date NNP cord-010092-uftc8inx 4435 27 . . . cord-010092-uftc8inx 4436 1 The the DT cord-010092-uftc8inx 4436 2 data datum NNS cord-010092-uftc8inx 4436 3 was be VBD cord-010092-uftc8inx 4436 4 encoded encode VBN cord-010092-uftc8inx 4436 5 using use VBG cord-010092-uftc8inx 4436 6 the the DT cord-010092-uftc8inx 4436 7 ISBT ISBT NNP cord-010092-uftc8inx 4436 8 128 128 CD cord-010092-uftc8inx 4436 9 format format NN cord-010092-uftc8inx 4436 10 . . . cord-010092-uftc8inx 4437 1 The the DT cord-010092-uftc8inx 4437 2 different different JJ cord-010092-uftc8inx 4437 3 processing processing NN cord-010092-uftc8inx 4437 4 steps step NNS cord-010092-uftc8inx 4437 5 and and CC cord-010092-uftc8inx 4437 6 conditions condition NNS cord-010092-uftc8inx 4437 7 tested test VBN cord-010092-uftc8inx 4437 8 were be VBD cord-010092-uftc8inx 4437 9 : : : cord-010092-uftc8inx 4438 1 -Centrifugation -centrifugation NN cord-010092-uftc8inx 4438 2 : : : cord-010092-uftc8inx 4439 1 Quintuple quintuple VB cord-010092-uftc8inx 4439 2 whole whole JJ cord-010092-uftc8inx 4439 3 blood blood NN cord-010092-uftc8inx 4439 4 bags bag NNS cord-010092-uftc8inx 4439 5 , , , cord-010092-uftc8inx 4439 6 filled fill VBN cord-010092-uftc8inx 4439 7 with with IN cord-010092-uftc8inx 4439 8 450 450 CD cord-010092-uftc8inx 4439 9 ml ml NN cord-010092-uftc8inx 4439 10 water water NN cord-010092-uftc8inx 4439 11 . . . cord-010092-uftc8inx 4440 1 Centrifugation Centrifugation NNP cord-010092-uftc8inx 4440 2 at at IN cord-010092-uftc8inx 4440 3 4,500 4,500 CD cord-010092-uftc8inx 4440 4 rpm rpm NN cord-010092-uftc8inx 4440 5 for for IN cord-010092-uftc8inx 4440 6 10 10 CD cord-010092-uftc8inx 4440 7 min min NN cord-010092-uftc8inx 4440 8 . . . cord-010092-uftc8inx 4441 1 270 270 CD cord-010092-uftc8inx 4441 2 tags tag NNS cord-010092-uftc8inx 4441 3 processed process VBN cord-010092-uftc8inx 4441 4 , , , cord-010092-uftc8inx 4441 5 15 15 CD cord-010092-uftc8inx 4441 6 tags tag NNS cord-010092-uftc8inx 4441 7 per per IN cord-010092-uftc8inx 4441 8 kit kit NN cord-010092-uftc8inx 4441 9 affixed affix VBN cord-010092-uftc8inx 4441 10 at at IN cord-010092-uftc8inx 4441 11 different different JJ cord-010092-uftc8inx 4441 12 positions position NNS cord-010092-uftc8inx 4441 13 . . . cord-010092-uftc8inx 4442 1 -Shock -shock NN cord-010092-uftc8inx 4442 2 - - HYPH cord-010092-uftc8inx 4442 3 Freezing freeze VBG cord-010092-uftc8inx 4442 4 at at IN cord-010092-uftc8inx 4442 5 À80 À80 NNP cord-010092-uftc8inx 4442 6 ° ° NN cord-010092-uftc8inx 4443 1 C c NN cord-010092-uftc8inx 4443 2 : : : cord-010092-uftc8inx 4443 3 Shock shock NN cord-010092-uftc8inx 4443 4 - - HYPH cord-010092-uftc8inx 4443 5 freezer freezer NN cord-010092-uftc8inx 4443 6 ( ( -LRB- cord-010092-uftc8inx 4443 7 Angelantoni Angelantoni NNP cord-010092-uftc8inx 4443 8 , , , cord-010092-uftc8inx 4443 9 SF40 SF40 NNP cord-010092-uftc8inx 4443 10 ) ) -RRB- cord-010092-uftc8inx 4443 11 , , . cord-010092-uftc8inx 4444 1 50 50 CD cord-010092-uftc8inx 4444 2 units unit NNS cord-010092-uftc8inx 4444 3 processed process VBN cord-010092-uftc8inx 4444 4 , , , cord-010092-uftc8inx 4444 5 reading read VBG cord-010092-uftc8inx 4444 6 immediately immediately RB cord-010092-uftc8inx 4444 7 after after IN cord-010092-uftc8inx 4444 8 removal removal NN cord-010092-uftc8inx 4444 9 from from IN cord-010092-uftc8inx 4444 10 shock shock NN cord-010092-uftc8inx 4444 11 freezer freezer NN cord-010092-uftc8inx 4444 12 . . . cord-010092-uftc8inx 4445 1 water water NN cord-010092-uftc8inx 4445 2 , , , cord-010092-uftc8inx 4445 3 30 30 CD cord-010092-uftc8inx 4445 4 tags tag NNS cord-010092-uftc8inx 4445 5 irradiated irradiate VBN cord-010092-uftc8inx 4445 6 at at IN cord-010092-uftc8inx 4445 7 30 30 CD cord-010092-uftc8inx 4445 8 Gy Gy NNP cord-010092-uftc8inx 4445 9 and and CC cord-010092-uftc8inx 4445 10 30 30 CD cord-010092-uftc8inx 4445 11 tags tag NNS cord-010092-uftc8inx 4445 12 at at IN cord-010092-uftc8inx 4445 13 50 50 CD cord-010092-uftc8inx 4445 14 Gy Gy NNP cord-010092-uftc8inx 4445 15 Results result NNS cord-010092-uftc8inx 4445 16 : : : cord-010092-uftc8inx 4445 17 All all DT cord-010092-uftc8inx 4445 18 Biolog Biolog NNP cord-010092-uftc8inx 4445 19 - - HYPH cord-010092-uftc8inx 4445 20 id id NNP cord-010092-uftc8inx 4445 21 tags tag NNS cord-010092-uftc8inx 4445 22 were be VBD cord-010092-uftc8inx 4445 23 encoded encode VBN cord-010092-uftc8inx 4445 24 and and CC cord-010092-uftc8inx 4445 25 read read VBN cord-010092-uftc8inx 4445 26 with with IN cord-010092-uftc8inx 4445 27 a a DT cord-010092-uftc8inx 4445 28 100 100 CD cord-010092-uftc8inx 4445 29 % % NN cord-010092-uftc8inx 4445 30 success success NN cord-010092-uftc8inx 4445 31 rate rate NN cord-010092-uftc8inx 4445 32 in in IN cord-010092-uftc8inx 4445 33 all all DT cord-010092-uftc8inx 4445 34 series series NN cord-010092-uftc8inx 4445 35 of of IN cord-010092-uftc8inx 4445 36 tests test NNS cord-010092-uftc8inx 4445 37 . . . cord-010092-uftc8inx 4446 1 Summary Summary NNP cord-010092-uftc8inx 4446 2 / / SYM cord-010092-uftc8inx 4446 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 4446 4 : : : cord-010092-uftc8inx 4446 5 Biolog Biolog NNP cord-010092-uftc8inx 4446 6 - - HYPH cord-010092-uftc8inx 4446 7 id id NNP cord-010092-uftc8inx 4446 8 RFID RFID NNP cord-010092-uftc8inx 4446 9 tags tag NNS cord-010092-uftc8inx 4446 10 can can MD cord-010092-uftc8inx 4446 11 be be VB cord-010092-uftc8inx 4446 12 encoded encode VBN cord-010092-uftc8inx 4446 13 and and CC cord-010092-uftc8inx 4446 14 read read VBN cord-010092-uftc8inx 4446 15 through through IN cord-010092-uftc8inx 4446 16 common common JJ cord-010092-uftc8inx 4446 17 processes process NNS cord-010092-uftc8inx 4446 18 used use VBN cord-010092-uftc8inx 4446 19 throughout throughout IN cord-010092-uftc8inx 4446 20 the the DT cord-010092-uftc8inx 4446 21 blood blood NN cord-010092-uftc8inx 4446 22 transfusion transfusion NN cord-010092-uftc8inx 4446 23 chain chain NN cord-010092-uftc8inx 4446 24 . . . cord-010092-uftc8inx 4447 1 Their -PRON- PRP$ cord-010092-uftc8inx 4447 2 mechanical mechanical JJ cord-010092-uftc8inx 4447 3 and and CC cord-010092-uftc8inx 4447 4 functional functional JJ cord-010092-uftc8inx 4447 5 integrity integrity NN cord-010092-uftc8inx 4447 6 is be VBZ cord-010092-uftc8inx 4447 7 not not RB cord-010092-uftc8inx 4447 8 affected affect VBN cord-010092-uftc8inx 4447 9 by by IN cord-010092-uftc8inx 4447 10 centrifugation centrifugation NN cord-010092-uftc8inx 4447 11 , , , cord-010092-uftc8inx 4447 12 shock shock NN cord-010092-uftc8inx 4447 13 - - HYPH cord-010092-uftc8inx 4447 14 freezing freeze VBG cord-010092-uftc8inx 4447 15 , , , cord-010092-uftc8inx 4447 16 intensive intensive JJ cord-010092-uftc8inx 4447 17 reading reading NN cord-010092-uftc8inx 4447 18 at at IN cord-010092-uftc8inx 4447 19 À40 À40 NNP cord-010092-uftc8inx 4447 20 ° ° NN cord-010092-uftc8inx 4447 21 C c NN cord-010092-uftc8inx 4447 22 , , , cord-010092-uftc8inx 4447 23 printing printing NN cord-010092-uftc8inx 4447 24 , , , cord-010092-uftc8inx 4447 25 ETO ETO NNP cord-010092-uftc8inx 4447 26 sterilization sterilization NN cord-010092-uftc8inx 4447 27 and and CC cord-010092-uftc8inx 4447 28 irradiation irradiation NN cord-010092-uftc8inx 4447 29 . . . cord-010092-uftc8inx 4448 1 Background background NN cord-010092-uftc8inx 4448 2 : : : cord-010092-uftc8inx 4449 1 The the DT cord-010092-uftc8inx 4449 2 provisioning provisioning NN cord-010092-uftc8inx 4449 3 of of IN cord-010092-uftc8inx 4449 4 compatible compatible JJ cord-010092-uftc8inx 4449 5 red red JJ cord-010092-uftc8inx 4449 6 blood blood NN cord-010092-uftc8inx 4449 7 cells cell NNS cord-010092-uftc8inx 4449 8 by by IN cord-010092-uftc8inx 4449 9 international international JJ cord-010092-uftc8inx 4449 10 cooperation cooperation NN cord-010092-uftc8inx 4449 11 is be VBZ cord-010092-uftc8inx 4449 12 presented present VBN cord-010092-uftc8inx 4449 13 . . . cord-010092-uftc8inx 4450 1 The the DT cord-010092-uftc8inx 4450 2 units unit NNS cord-010092-uftc8inx 4450 3 were be VBD cord-010092-uftc8inx 4450 4 meant mean VBN cord-010092-uftc8inx 4450 5 for for IN cord-010092-uftc8inx 4450 6 an an DT cord-010092-uftc8inx 4450 7 18-year 18-year JJ cord-010092-uftc8inx 4450 8 old old JJ cord-010092-uftc8inx 4450 9 female female NN cord-010092-uftc8inx 4450 10 , , , cord-010092-uftc8inx 4450 11 with with IN cord-010092-uftc8inx 4450 12 homozygous homozygous JJ cord-010092-uftc8inx 4450 13 sickle sickle NN cord-010092-uftc8inx 4450 14 cell cell NN cord-010092-uftc8inx 4450 15 disease disease NN cord-010092-uftc8inx 4450 16 ( ( -LRB- cord-010092-uftc8inx 4450 17 SCD SCD NNP cord-010092-uftc8inx 4450 18 ) ) -RRB- cord-010092-uftc8inx 4450 19 and and CC cord-010092-uftc8inx 4450 20 multiple multiple JJ cord-010092-uftc8inx 4450 21 complications complication NNS cord-010092-uftc8inx 4450 22 . . . cord-010092-uftc8inx 4451 1 Patients patient NNS cord-010092-uftc8inx 4451 2 ' ' POS cord-010092-uftc8inx 4451 3 blood blood NN cord-010092-uftc8inx 4451 4 group group NN cord-010092-uftc8inx 4451 5 was be VBD cord-010092-uftc8inx 4451 6 A a DT cord-010092-uftc8inx 4451 7 positive positive JJ cord-010092-uftc8inx 4451 8 with with IN cord-010092-uftc8inx 4451 9 anti anti JJ cord-010092-uftc8inx 4451 10 - - JJ cord-010092-uftc8inx 4451 11 C c JJ cord-010092-uftc8inx 4451 12 , , , cord-010092-uftc8inx 4451 13 -e -e ADD cord-010092-uftc8inx 4451 14 , , , cord-010092-uftc8inx 4451 15 -Wr -Wr NNP cord-010092-uftc8inx 4451 16 a a NN cord-010092-uftc8inx 4451 17 and and CC cord-010092-uftc8inx 4451 18 an an DT cord-010092-uftc8inx 4451 19 antibody antibody NN cord-010092-uftc8inx 4451 20 to to IN cord-010092-uftc8inx 4451 21 a a DT cord-010092-uftc8inx 4451 22 high high JJ cord-010092-uftc8inx 4451 23 prevalence prevalence NN cord-010092-uftc8inx 4451 24 antigen antigen NN cord-010092-uftc8inx 4451 25 in in IN cord-010092-uftc8inx 4451 26 the the DT cord-010092-uftc8inx 4451 27 Rh Rh NNP cord-010092-uftc8inx 4451 28 system system NN cord-010092-uftc8inx 4451 29 , , , cord-010092-uftc8inx 4451 30 anti anti JJ cord-010092-uftc8inx 4451 31 - - JJ cord-010092-uftc8inx 4451 32 hr hr NN cord-010092-uftc8inx 4451 33 B b NN cord-010092-uftc8inx 4451 34 possibly possibly RB cord-010092-uftc8inx 4451 35 combined combine VBN cord-010092-uftc8inx 4451 36 with with IN cord-010092-uftc8inx 4451 37 anti anti JJ cord-010092-uftc8inx 4451 38 - - JJ cord-010092-uftc8inx 4451 39 Hr hr NN cord-010092-uftc8inx 4451 40 B b NN cord-010092-uftc8inx 4451 41 ( ( -LRB- cord-010092-uftc8inx 4451 42 Rh34 Rh34 NNP cord-010092-uftc8inx 4451 43 ) ) -RRB- cord-010092-uftc8inx 4451 44 . . . cord-010092-uftc8inx 4452 1 The the DT cord-010092-uftc8inx 4452 2 antibody antibody NN cord-010092-uftc8inx 4452 3 was be VBD cord-010092-uftc8inx 4452 4 not not RB cord-010092-uftc8inx 4452 5 reactive reactive JJ cord-010092-uftc8inx 4452 6 with with IN cord-010092-uftc8inx 4452 7 Rh Rh NNP cord-010092-uftc8inx 4452 8 null null NN cord-010092-uftc8inx 4452 9 , , , cord-010092-uftc8inx 4452 10 -D -d NN cord-010092-uftc8inx 4452 11 - - : cord-010092-uftc8inx 4452 12 or or CC cord-010092-uftc8inx 4452 13 Hr Hr NNP cord-010092-uftc8inx 4452 14 B B NNP cord-010092-uftc8inx 4452 15 negative negative JJ cord-010092-uftc8inx 4452 16 cells cell NNS cord-010092-uftc8inx 4452 17 . . . cord-010092-uftc8inx 4453 1 The the DT cord-010092-uftc8inx 4453 2 donor donor NN cord-010092-uftc8inx 4453 3 center center NN cord-010092-uftc8inx 4453 4 put put VBD cord-010092-uftc8inx 4453 5 out out RP cord-010092-uftc8inx 4453 6 an an DT cord-010092-uftc8inx 4453 7 international international JJ cord-010092-uftc8inx 4453 8 request request NN cord-010092-uftc8inx 4453 9 for for IN cord-010092-uftc8inx 4453 10 group group NN cord-010092-uftc8inx 4453 11 A A NNP cord-010092-uftc8inx 4453 12 or or CC cord-010092-uftc8inx 4453 13 O o UH cord-010092-uftc8inx 4453 14 , , , cord-010092-uftc8inx 4453 15 Rh Rh NNP cord-010092-uftc8inx 4453 16 null null NN cord-010092-uftc8inx 4453 17 or or CC cord-010092-uftc8inx 4453 18 -D -d NN cord-010092-uftc8inx 4453 19 - - HYPH cord-010092-uftc8inx 4453 20 units unit NNS cord-010092-uftc8inx 4453 21 lacking lack VBG cord-010092-uftc8inx 4454 1 Wr Wr NNP cord-010092-uftc8inx 4454 2 a a DT cord-010092-uftc8inx 4454 3 and and CC cord-010092-uftc8inx 4454 4 possibly possibly RB cord-010092-uftc8inx 4454 5 K k XX cord-010092-uftc8inx 4454 6 , , , cord-010092-uftc8inx 4455 1 Fy Fy NNP cord-010092-uftc8inx 4455 2 a a DT cord-010092-uftc8inx 4455 3 , , , cord-010092-uftc8inx 4456 1 Jk Jk NNP cord-010092-uftc8inx 4456 2 a a DT cord-010092-uftc8inx 4456 3 , , , cord-010092-uftc8inx 4456 4 Wr Wr NNP cord-010092-uftc8inx 4456 5 a a NNP cord-010092-uftc8inx 4456 6 , , , cord-010092-uftc8inx 4456 7 Do do VB cord-010092-uftc8inx 4456 8 a a DT cord-010092-uftc8inx 4456 9 and and CC cord-010092-uftc8inx 4456 10 S S NNP cord-010092-uftc8inx 4456 11 ( ( -LRB- cord-010092-uftc8inx 4456 12 the the DT cord-010092-uftc8inx 4456 13 latter latter JJ cord-010092-uftc8inx 4456 14 antigens antigen NNS cord-010092-uftc8inx 4456 15 for for IN cord-010092-uftc8inx 4456 16 prophylactic prophylactic JJ cord-010092-uftc8inx 4456 17 matching matching NN cord-010092-uftc8inx 4456 18 ) ) -RRB- cord-010092-uftc8inx 4456 19 . . . cord-010092-uftc8inx 4457 1 The the DT cord-010092-uftc8inx 4457 2 patient patient JJ cord-010092-uftc8inx 4457 3 sample sample NN cord-010092-uftc8inx 4457 4 had have VBD cord-010092-uftc8inx 4457 5 been be VBN cord-010092-uftc8inx 4457 6 genotyped genotype VBN cord-010092-uftc8inx 4457 7 for for IN cord-010092-uftc8inx 4457 8 RHD RHD NNP cord-010092-uftc8inx 4457 9 and and CC cord-010092-uftc8inx 4457 10 RHCE RHCE NNP cord-010092-uftc8inx 4457 11 using use VBG cord-010092-uftc8inx 4457 12 MLPA MLPA NNP cord-010092-uftc8inx 4457 13 and and CC cord-010092-uftc8inx 4457 14 Sanger Sanger NNP cord-010092-uftc8inx 4457 15 Sequencing Sequencing NNP cord-010092-uftc8inx 4457 16 and and CC cord-010092-uftc8inx 4457 17 the the DT cord-010092-uftc8inx 4457 18 patient patient NN cord-010092-uftc8inx 4457 19 was be VBD cord-010092-uftc8inx 4457 20 found find VBN cord-010092-uftc8inx 4457 21 to to TO cord-010092-uftc8inx 4457 22 carry carry VB cord-010092-uftc8inx 4457 23 RHD*01 rhd*01 CD cord-010092-uftc8inx 4457 24 / / SYM cord-010092-uftc8inx 4457 25 RHD*03N.01 rhd*03n.01 CD cord-010092-uftc8inx 4457 26 and and CC cord-010092-uftc8inx 4457 27 RHCE*ceVS.01/ RHCE*ceVS.01/ VBD cord-010092-uftc8inx 4457 28 RHCE*ceVS.03 RHCE*ceVS.03 NNP cord-010092-uftc8inx 4457 29 . . . cord-010092-uftc8inx 4458 1 Aims aim VBZ cord-010092-uftc8inx 4458 2 : : : cord-010092-uftc8inx 4459 1 The the DT cord-010092-uftc8inx 4459 2 request request NN cord-010092-uftc8inx 4459 3 was be VBD cord-010092-uftc8inx 4459 4 sent send VBN cord-010092-uftc8inx 4459 5 to to IN cord-010092-uftc8inx 4459 6 the the DT cord-010092-uftc8inx 4459 7 American American NNP cord-010092-uftc8inx 4459 8 Rare Rare NNP cord-010092-uftc8inx 4459 9 Donor Donor NNP cord-010092-uftc8inx 4459 10 Program Program NNP cord-010092-uftc8inx 4459 11 ( ( -LRB- cord-010092-uftc8inx 4459 12 ARDP ARDP NNP cord-010092-uftc8inx 4459 13 ) ) -RRB- cord-010092-uftc8inx 4459 14 . . . cord-010092-uftc8inx 4460 1 The the DT cord-010092-uftc8inx 4460 2 ARDP ARDP NNP cord-010092-uftc8inx 4460 3 working work VBG cord-010092-uftc8inx 4460 4 with with IN cord-010092-uftc8inx 4460 5 the the DT cord-010092-uftc8inx 4460 6 American American NNP cord-010092-uftc8inx 4460 7 Red Red NNP cord-010092-uftc8inx 4460 8 Cross Cross NNP cord-010092-uftc8inx 4460 9 National National NNP cord-010092-uftc8inx 4460 10 Molecular Molecular NNP cord-010092-uftc8inx 4460 11 Laboratory Laboratory NNP cord-010092-uftc8inx 4460 12 , , , cord-010092-uftc8inx 4460 13 used use VBD cord-010092-uftc8inx 4460 14 the the DT cord-010092-uftc8inx 4460 15 RH RH NNP cord-010092-uftc8inx 4460 16 genotype genotype NN cord-010092-uftc8inx 4460 17 information information NN cord-010092-uftc8inx 4460 18 to to TO cord-010092-uftc8inx 4460 19 identify identify VB cord-010092-uftc8inx 4460 20 donors donor NNS cord-010092-uftc8inx 4460 21 carrying carry VBG cord-010092-uftc8inx 4460 22 the the DT cord-010092-uftc8inx 4460 23 same same JJ cord-010092-uftc8inx 4460 24 or or CC cord-010092-uftc8inx 4460 25 similar similar JJ cord-010092-uftc8inx 4460 26 RH RH NNP cord-010092-uftc8inx 4460 27 variant variant NN cord-010092-uftc8inx 4460 28 alleles allele NNS cord-010092-uftc8inx 4460 29 using use VBG cord-010092-uftc8inx 4460 30 the the DT cord-010092-uftc8inx 4460 31 RH RH NNP cord-010092-uftc8inx 4460 32 allele allele NN cord-010092-uftc8inx 4460 33 matching matching NN cord-010092-uftc8inx 4460 34 approach approach NN cord-010092-uftc8inx 4460 35 described describe VBN cord-010092-uftc8inx 4460 36 previously previously RB cord-010092-uftc8inx 4460 37 ( ( -LRB- cord-010092-uftc8inx 4460 38 Keller Keller NNP cord-010092-uftc8inx 4460 39 et et NNP cord-010092-uftc8inx 4460 40 al al NNP cord-010092-uftc8inx 4460 41 . . . cord-010092-uftc8inx 4461 1 Transfusion transfusion NN cord-010092-uftc8inx 4461 2 2013 2013 CD cord-010092-uftc8inx 4461 3 53(2S):174A 53(2s):174a CD cord-010092-uftc8inx 4461 4 ) ) -RRB- cord-010092-uftc8inx 4461 5 . . . cord-010092-uftc8inx 4462 1 Methods method NNS cord-010092-uftc8inx 4462 2 : : : cord-010092-uftc8inx 4462 3 A a DT cord-010092-uftc8inx 4462 4 recent recent JJ cord-010092-uftc8inx 4462 5 blood blood NN cord-010092-uftc8inx 4462 6 sample sample NN cord-010092-uftc8inx 4462 7 was be VBD cord-010092-uftc8inx 4462 8 used use VBN cord-010092-uftc8inx 4462 9 to to TO cord-010092-uftc8inx 4462 10 confirm confirm VB cord-010092-uftc8inx 4462 11 anti anti NNP cord-010092-uftc8inx 4462 12 - - JJ cord-010092-uftc8inx 4462 13 hr hr NN cord-010092-uftc8inx 4462 14 B b NN cord-010092-uftc8inx 4463 1 ; ; : cord-010092-uftc8inx 4463 2 no no DT cord-010092-uftc8inx 4463 3 anti anti JJ cord-010092-uftc8inx 4463 4 - - JJ cord-010092-uftc8inx 4463 5 Hr Hr NNP cord-010092-uftc8inx 4463 6 B B NNP cord-010092-uftc8inx 4463 7 was be VBD cord-010092-uftc8inx 4463 8 detected detect VBN cord-010092-uftc8inx 4463 9 . . . cord-010092-uftc8inx 4464 1 The the DT cord-010092-uftc8inx 4464 2 patient patient JJ cord-010092-uftc8inx 4464 3 RHD RHD NNP cord-010092-uftc8inx 4464 4 and and CC cord-010092-uftc8inx 4464 5 RHCE RHCE NNP cord-010092-uftc8inx 4464 6 alleles allele NNS cord-010092-uftc8inx 4464 7 were be VBD cord-010092-uftc8inx 4464 8 used use VBN cord-010092-uftc8inx 4464 9 to to TO cord-010092-uftc8inx 4464 10 build build VB cord-010092-uftc8inx 4464 11 Punnett Punnett NNP cord-010092-uftc8inx 4464 12 squares square NNS cord-010092-uftc8inx 4464 13 for for IN cord-010092-uftc8inx 4464 14 both both DT cord-010092-uftc8inx 4464 15 genes gene NNS cord-010092-uftc8inx 4464 16 with with IN cord-010092-uftc8inx 4464 17 donors donor NNS cord-010092-uftc8inx 4464 18 carrying carry VBG cord-010092-uftc8inx 4464 19 the the DT cord-010092-uftc8inx 4464 20 same same JJ cord-010092-uftc8inx 4464 21 and and CC cord-010092-uftc8inx 4464 22 similar similar JJ cord-010092-uftc8inx 4464 23 alleles allele NNS cord-010092-uftc8inx 4464 24 that that WDT cord-010092-uftc8inx 4464 25 would would MD cord-010092-uftc8inx 4464 26 be be VB cord-010092-uftc8inx 4464 27 predicted predict VBN cord-010092-uftc8inx 4464 28 to to TO cord-010092-uftc8inx 4464 29 be be VB cord-010092-uftc8inx 4464 30 compatible compatible JJ cord-010092-uftc8inx 4464 31 . . . cord-010092-uftc8inx 4465 1 Tier tier NN cord-010092-uftc8inx 4465 2 1 1 CD cord-010092-uftc8inx 4465 3 donors donor NNS cord-010092-uftc8inx 4465 4 are be VBP cord-010092-uftc8inx 4465 5 those those DT cord-010092-uftc8inx 4465 6 predicted predict VBN cord-010092-uftc8inx 4465 7 to to TO cord-010092-uftc8inx 4465 8 carry carry VB cord-010092-uftc8inx 4465 9 the the DT cord-010092-uftc8inx 4465 10 same same JJ cord-010092-uftc8inx 4465 11 combination combination NN cord-010092-uftc8inx 4465 12 of of IN cord-010092-uftc8inx 4465 13 RHD RHD NNP cord-010092-uftc8inx 4465 14 and and CC cord-010092-uftc8inx 4465 15 RHCE RHCE NNP cord-010092-uftc8inx 4465 16 alleles allele NNS cord-010092-uftc8inx 4465 17 as as IN cord-010092-uftc8inx 4465 18 the the DT cord-010092-uftc8inx 4465 19 patient patient NN cord-010092-uftc8inx 4465 20 . . . cord-010092-uftc8inx 4466 1 Tier tier NN cord-010092-uftc8inx 4466 2 2 2 CD cord-010092-uftc8inx 4466 3 donors donor NNS cord-010092-uftc8inx 4466 4 are be VBP cord-010092-uftc8inx 4466 5 those those DT cord-010092-uftc8inx 4466 6 predicted predict VBN cord-010092-uftc8inx 4466 7 to to TO cord-010092-uftc8inx 4466 8 be be VB cord-010092-uftc8inx 4466 9 homozygous homozygous JJ cord-010092-uftc8inx 4466 10 for for IN cord-010092-uftc8inx 4466 11 one one CD cord-010092-uftc8inx 4466 12 of of IN cord-010092-uftc8inx 4466 13 the the DT cord-010092-uftc8inx 4466 14 allele allele NN cord-010092-uftc8inx 4466 15 combinations combination NNS cord-010092-uftc8inx 4466 16 carried carry VBN cord-010092-uftc8inx 4466 17 by by IN cord-010092-uftc8inx 4466 18 the the DT cord-010092-uftc8inx 4466 19 patient patient NN cord-010092-uftc8inx 4466 20 . . . cord-010092-uftc8inx 4467 1 Tier tier NN cord-010092-uftc8inx 4467 2 3 3 CD cord-010092-uftc8inx 4467 3 donors donor NNS cord-010092-uftc8inx 4467 4 are be VBP cord-010092-uftc8inx 4467 5 those those DT cord-010092-uftc8inx 4467 6 predicted predict VBN cord-010092-uftc8inx 4467 7 to to TO cord-010092-uftc8inx 4467 8 carry carry VB cord-010092-uftc8inx 4467 9 alleles allele NNS cord-010092-uftc8inx 4467 10 similar similar JJ cord-010092-uftc8inx 4467 11 ( ( -LRB- cord-010092-uftc8inx 4467 12 but but CC cord-010092-uftc8inx 4467 13 not not RB cord-010092-uftc8inx 4467 14 identical identical JJ cord-010092-uftc8inx 4467 15 ) ) -RRB- cord-010092-uftc8inx 4467 16 to to IN cord-010092-uftc8inx 4467 17 those those DT cord-010092-uftc8inx 4467 18 carried carry VBN cord-010092-uftc8inx 4467 19 by by IN cord-010092-uftc8inx 4467 20 the the DT cord-010092-uftc8inx 4467 21 patient patient NN cord-010092-uftc8inx 4467 22 , , , cord-010092-uftc8inx 4467 23 with with IN cord-010092-uftc8inx 4467 24 similar similar JJ cord-010092-uftc8inx 4467 25 predicted predict VBN cord-010092-uftc8inx 4467 26 phenotype phenotype NN cord-010092-uftc8inx 4467 27 . . . cord-010092-uftc8inx 4468 1 The the DT cord-010092-uftc8inx 4468 2 database database NN cord-010092-uftc8inx 4468 3 of of IN cord-010092-uftc8inx 4468 4 donors donor NNS cord-010092-uftc8inx 4468 5 in in IN cord-010092-uftc8inx 4468 6 the the DT cord-010092-uftc8inx 4468 7 ARDP ARDP NNP cord-010092-uftc8inx 4468 8 carrying carry VBG cord-010092-uftc8inx 4468 9 RH RH NNP cord-010092-uftc8inx 4468 10 variant variant NN cord-010092-uftc8inx 4468 11 alleles allele NNS cord-010092-uftc8inx 4468 12 was be VBD cord-010092-uftc8inx 4468 13 queried query VBN cord-010092-uftc8inx 4468 14 against against IN cord-010092-uftc8inx 4468 15 the the DT cord-010092-uftc8inx 4468 16 alleles allele NNS cord-010092-uftc8inx 4468 17 in in IN cord-010092-uftc8inx 4468 18 the the DT cord-010092-uftc8inx 4468 19 patient patient NN cord-010092-uftc8inx 4468 20 - - HYPH cord-010092-uftc8inx 4468 21 specific specific JJ cord-010092-uftc8inx 4468 22 Punnett Punnett NNP cord-010092-uftc8inx 4468 23 Square Square NNP cord-010092-uftc8inx 4468 24 . . . cord-010092-uftc8inx 4469 1 Results result NNS cord-010092-uftc8inx 4469 2 : : : cord-010092-uftc8inx 4469 3 Donors donor NNS cord-010092-uftc8inx 4469 4 of of IN cord-010092-uftc8inx 4469 5 group group NN cord-010092-uftc8inx 4469 6 A A NNP cord-010092-uftc8inx 4469 7 or or CC cord-010092-uftc8inx 4469 8 O o UH cord-010092-uftc8inx 4469 9 and and CC cord-010092-uftc8inx 4469 10 matched match VBN cord-010092-uftc8inx 4469 11 for for IN cord-010092-uftc8inx 4469 12 RH RH NNP cord-010092-uftc8inx 4469 13 alleles allele NNS cord-010092-uftc8inx 4469 14 were be VBD cord-010092-uftc8inx 4469 15 identified identify VBN cord-010092-uftc8inx 4469 16 as as IN cord-010092-uftc8inx 4469 17 follows follow VBZ cord-010092-uftc8inx 4469 18 : : : cord-010092-uftc8inx 4469 19 102 102 CD cord-010092-uftc8inx 4469 20 Tier Tier NNP cord-010092-uftc8inx 4469 21 1 1 CD cord-010092-uftc8inx 4469 22 , , , cord-010092-uftc8inx 4469 23 357 357 CD cord-010092-uftc8inx 4469 24 Tier Tier NNP cord-010092-uftc8inx 4469 25 2 2 CD cord-010092-uftc8inx 4469 26 and and CC cord-010092-uftc8inx 4469 27 100 100 CD cord-010092-uftc8inx 4469 28 tier tier NN cord-010092-uftc8inx 4469 29 3 3 CD cord-010092-uftc8inx 4469 30 donors donor NNS cord-010092-uftc8inx 4469 31 . . . cord-010092-uftc8inx 4470 1 After after IN cord-010092-uftc8inx 4470 2 the the DT cord-010092-uftc8inx 4470 3 clinical clinical JJ cord-010092-uftc8inx 4470 4 team team NN cord-010092-uftc8inx 4470 5 agreed agree VBD cord-010092-uftc8inx 4470 6 to to TO cord-010092-uftc8inx 4470 7 drop drop VB cord-010092-uftc8inx 4470 8 one one CD cord-010092-uftc8inx 4470 9 or or CC cord-010092-uftc8inx 4470 10 more more JJR cord-010092-uftc8inx 4470 11 of of IN cord-010092-uftc8inx 4470 12 the the DT cord-010092-uftc8inx 4470 13 prophylactic prophylactic JJ cord-010092-uftc8inx 4470 14 antigen antigen NN cord-010092-uftc8inx 4470 15 matches match NNS cord-010092-uftc8inx 4470 16 , , , cord-010092-uftc8inx 4470 17 one one CD cord-010092-uftc8inx 4470 18 tier tier NN cord-010092-uftc8inx 4470 19 2 2 CD cord-010092-uftc8inx 4470 20 unit unit NN cord-010092-uftc8inx 4470 21 lacking lack VBG cord-010092-uftc8inx 4470 22 S S NNP cord-010092-uftc8inx 4470 23 and and CC cord-010092-uftc8inx 4470 24 Jk Jk NNP cord-010092-uftc8inx 4471 1 a a DT cord-010092-uftc8inx 4471 2 was be VBD cord-010092-uftc8inx 4471 3 identified identify VBN cord-010092-uftc8inx 4471 4 at at IN cord-010092-uftc8inx 4471 5 the the DT cord-010092-uftc8inx 4471 6 American American NNP cord-010092-uftc8inx 4471 7 Red Red NNP cord-010092-uftc8inx 4471 8 Cross Cross NNP cord-010092-uftc8inx 4471 9 . . . cord-010092-uftc8inx 4472 1 While while IN cord-010092-uftc8inx 4472 2 the the DT cord-010092-uftc8inx 4472 3 request request NN cord-010092-uftc8inx 4472 4 was be VBD cord-010092-uftc8inx 4472 5 being be VBG cord-010092-uftc8inx 4472 6 processed process VBN cord-010092-uftc8inx 4472 7 , , , cord-010092-uftc8inx 4472 8 the the DT cord-010092-uftc8inx 4472 9 patient patient NN cord-010092-uftc8inx 4472 10 experienced experience VBD cord-010092-uftc8inx 4472 11 a a DT cord-010092-uftc8inx 4472 12 sickle sickle NN cord-010092-uftc8inx 4472 13 cell cell NN cord-010092-uftc8inx 4472 14 crisis crisis NN cord-010092-uftc8inx 4472 15 , , , cord-010092-uftc8inx 4472 16 red red JJ cord-010092-uftc8inx 4472 17 cell cell NN cord-010092-uftc8inx 4472 18 aplasia aplasia NNP cord-010092-uftc8inx 4472 19 and and CC cord-010092-uftc8inx 4472 20 recurrent recurrent JJ cord-010092-uftc8inx 4472 21 AIHA AIHA NNP cord-010092-uftc8inx 4472 22 and and CC cord-010092-uftc8inx 4472 23 her -PRON- PRP$ cord-010092-uftc8inx 4472 24 hemoglobin hemoglobin NN cord-010092-uftc8inx 4472 25 level level NN cord-010092-uftc8inx 4472 26 dropped drop VBD cord-010092-uftc8inx 4472 27 from from IN cord-010092-uftc8inx 4472 28 7 7 CD cord-010092-uftc8inx 4472 29 to to TO cord-010092-uftc8inx 4472 30 1.9 1.9 CD cord-010092-uftc8inx 4472 31 g g NN cord-010092-uftc8inx 4472 32 / / SYM cord-010092-uftc8inx 4472 33 dL. dl. NN cord-010092-uftc8inx 4473 1 At at IN cord-010092-uftc8inx 4473 2 that that DT cord-010092-uftc8inx 4473 3 time time NN cord-010092-uftc8inx 4473 4 , , , cord-010092-uftc8inx 4473 5 she -PRON- PRP cord-010092-uftc8inx 4473 6 was be VBD cord-010092-uftc8inx 4473 7 transfused transfuse VBN cord-010092-uftc8inx 4473 8 the the DT cord-010092-uftc8inx 4473 9 only only JJ cord-010092-uftc8inx 4473 10 compatible compatible JJ cord-010092-uftc8inx 4473 11 units unit NNS cord-010092-uftc8inx 4473 12 available available JJ cord-010092-uftc8inx 4473 13 -2 -2 CD cord-010092-uftc8inx 4473 14 of of IN cord-010092-uftc8inx 4473 15 the the DT cord-010092-uftc8inx 4473 16 rare rare JJ cord-010092-uftc8inx 4473 17 -Dphenotype -Dphenotype : cord-010092-uftc8inx 4473 18 and and CC cord-010092-uftc8inx 4473 19 her -PRON- PRP$ cord-010092-uftc8inx 4473 20 Hb Hb NNP cord-010092-uftc8inx 4473 21 increased increase VBD cord-010092-uftc8inx 4473 22 to to IN cord-010092-uftc8inx 4473 23 3.8 3.8 CD cord-010092-uftc8inx 4473 24 g g NN cord-010092-uftc8inx 4473 25 / / SYM cord-010092-uftc8inx 4473 26 dL dl NN cord-010092-uftc8inx 4473 27 and and CC cord-010092-uftc8inx 4473 28 eventually eventually RB cord-010092-uftc8inx 4473 29 to to IN cord-010092-uftc8inx 4473 30 7 7 CD cord-010092-uftc8inx 4473 31 g g NN cord-010092-uftc8inx 4473 32 / / SYM cord-010092-uftc8inx 4473 33 dL. dL. NNS cord-010092-uftc8inx 4474 1 The the DT cord-010092-uftc8inx 4474 2 Tier Tier NNP cord-010092-uftc8inx 4474 3 2 2 CD cord-010092-uftc8inx 4474 4 RH RH NNP cord-010092-uftc8inx 4474 5 allele allele NN cord-010092-uftc8inx 4474 6 matched match VBN cord-010092-uftc8inx 4474 7 unit unit NN cord-010092-uftc8inx 4474 8 was be VBD cord-010092-uftc8inx 4474 9 shipped ship VBN cord-010092-uftc8inx 4474 10 to to IN cord-010092-uftc8inx 4474 11 Amsterdam Amsterdam NNP cord-010092-uftc8inx 4474 12 where where WRB cord-010092-uftc8inx 4474 13 it -PRON- PRP cord-010092-uftc8inx 4474 14 was be VBD cord-010092-uftc8inx 4474 15 frozen frozen JJ cord-010092-uftc8inx 4474 16 , , , cord-010092-uftc8inx 4474 17 and and CC cord-010092-uftc8inx 4474 18 reserved reserve VBN cord-010092-uftc8inx 4474 19 for for IN cord-010092-uftc8inx 4474 20 the the DT cord-010092-uftc8inx 4474 21 transfusion transfusion NN cord-010092-uftc8inx 4474 22 care care NN cord-010092-uftc8inx 4474 23 of of IN cord-010092-uftc8inx 4474 24 this this DT cord-010092-uftc8inx 4474 25 patient patient NN cord-010092-uftc8inx 4474 26 . . . cord-010092-uftc8inx 4475 1 Summary Summary NNP cord-010092-uftc8inx 4475 2 / / SYM cord-010092-uftc8inx 4475 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 4475 4 : : : cord-010092-uftc8inx 4476 1 This this DT cord-010092-uftc8inx 4476 2 case case NN cord-010092-uftc8inx 4476 3 illustrates illustrate VBZ cord-010092-uftc8inx 4476 4 how how WRB cord-010092-uftc8inx 4476 5 RH RH NNP cord-010092-uftc8inx 4476 6 allele allele NN cord-010092-uftc8inx 4476 7 matched match VBD cord-010092-uftc8inx 4476 8 blood blood NN cord-010092-uftc8inx 4476 9 can can MD cord-010092-uftc8inx 4476 10 be be VB cord-010092-uftc8inx 4476 11 found find VBN cord-010092-uftc8inx 4476 12 for for IN cord-010092-uftc8inx 4476 13 a a DT cord-010092-uftc8inx 4476 14 highly highly RB cord-010092-uftc8inx 4476 15 Rh Rh NNP cord-010092-uftc8inx 4476 16 alloimmunized alloimmunize VBN cord-010092-uftc8inx 4476 17 patient patient NN cord-010092-uftc8inx 4476 18 , , , cord-010092-uftc8inx 4476 19 and and CC cord-010092-uftc8inx 4476 20 can can MD cord-010092-uftc8inx 4476 21 avoid avoid VB cord-010092-uftc8inx 4476 22 use use NN cord-010092-uftc8inx 4476 23 of of IN cord-010092-uftc8inx 4476 24 the the DT cord-010092-uftc8inx 4476 25 exquisitely exquisitely RB cord-010092-uftc8inx 4476 26 rare rare JJ cord-010092-uftc8inx 4476 27 -D -d NN cord-010092-uftc8inx 4476 28 - - : cord-010092-uftc8inx 4476 29 or or CC cord-010092-uftc8inx 4476 30 Rh Rh NNP cord-010092-uftc8inx 4476 31 null null JJ cord-010092-uftc8inx 4476 32 blood blood NN cord-010092-uftc8inx 4476 33 . . . cord-010092-uftc8inx 4477 1 Background background NN cord-010092-uftc8inx 4477 2 : : : cord-010092-uftc8inx 4478 1 Blood blood NN cord-010092-uftc8inx 4478 2 transfusion transfusion NN cord-010092-uftc8inx 4478 3 has have VBZ cord-010092-uftc8inx 4478 4 been be VBN cord-010092-uftc8inx 4478 5 a a DT cord-010092-uftc8inx 4478 6 complicated complicated JJ cord-010092-uftc8inx 4478 7 and and CC cord-010092-uftc8inx 4478 8 high high JJ cord-010092-uftc8inx 4478 9 - - HYPH cord-010092-uftc8inx 4478 10 risky risky JJ cord-010092-uftc8inx 4478 11 clinical clinical JJ cord-010092-uftc8inx 4478 12 procedure procedure NN cord-010092-uftc8inx 4478 13 . . . cord-010092-uftc8inx 4479 1 Any any DT cord-010092-uftc8inx 4479 2 error error NN cord-010092-uftc8inx 4479 3 could could MD cord-010092-uftc8inx 4479 4 cause cause VB cord-010092-uftc8inx 4479 5 serious serious JJ cord-010092-uftc8inx 4479 6 injuries injury NNS cord-010092-uftc8inx 4479 7 to to IN cord-010092-uftc8inx 4479 8 patients patient NNS cord-010092-uftc8inx 4479 9 . . . cord-010092-uftc8inx 4480 1 To to TO cord-010092-uftc8inx 4480 2 better better RB cord-010092-uftc8inx 4480 3 assure assure VB cord-010092-uftc8inx 4480 4 the the DT cord-010092-uftc8inx 4480 5 procedure procedure NN cord-010092-uftc8inx 4480 6 safety safety NN cord-010092-uftc8inx 4480 7 . . . cord-010092-uftc8inx 4481 1 Aims aim VBZ cord-010092-uftc8inx 4481 2 : : : cord-010092-uftc8inx 4481 3 We -PRON- PRP cord-010092-uftc8inx 4481 4 enhanced enhance VBD cord-010092-uftc8inx 4481 5 and and CC cord-010092-uftc8inx 4481 6 built build VBD cord-010092-uftc8inx 4481 7 a a DT cord-010092-uftc8inx 4481 8 blood blood NN cord-010092-uftc8inx 4481 9 transfusion transfusion NN cord-010092-uftc8inx 4481 10 database database NN cord-010092-uftc8inx 4481 11 platform platform NN cord-010092-uftc8inx 4481 12 and and CC cord-010092-uftc8inx 4481 13 develop develop VB cord-010092-uftc8inx 4481 14 inventory inventory NN cord-010092-uftc8inx 4481 15 management management NN cord-010092-uftc8inx 4481 16 strategies strategy NNS cord-010092-uftc8inx 4481 17 to to TO cord-010092-uftc8inx 4481 18 better better RB cord-010092-uftc8inx 4481 19 guarantee guarantee VB cord-010092-uftc8inx 4481 20 the the DT cord-010092-uftc8inx 4481 21 patient patient JJ cord-010092-uftc8inx 4481 22 transfusion transfusion NN cord-010092-uftc8inx 4481 23 safety safety NN cord-010092-uftc8inx 4481 24 . . . cord-010092-uftc8inx 4482 1 Methods method NNS cord-010092-uftc8inx 4482 2 : : : cord-010092-uftc8inx 4482 3 We -PRON- PRP cord-010092-uftc8inx 4482 4 designed design VBD cord-010092-uftc8inx 4482 5 six six CD cord-010092-uftc8inx 4482 6 new new JJ cord-010092-uftc8inx 4482 7 features feature NNS cord-010092-uftc8inx 4482 8 of of IN cord-010092-uftc8inx 4482 9 the the DT cord-010092-uftc8inx 4482 10 platform platform NN cord-010092-uftc8inx 4482 11 ( ( -LRB- cord-010092-uftc8inx 4482 12 1 1 LS cord-010092-uftc8inx 4482 13 ) ) -RRB- cord-010092-uftc8inx 4482 14 assuring assure VBG cord-010092-uftc8inx 4482 15 the the DT cord-010092-uftc8inx 4482 16 patient patient NN cord-010092-uftc8inx 4482 17 identification identification NN cord-010092-uftc8inx 4482 18 with with IN cord-010092-uftc8inx 4482 19 barcode barcode NN cord-010092-uftc8inx 4482 20 techniques technique NNS cord-010092-uftc8inx 4482 21 ; ; , cord-010092-uftc8inx 4482 22 ( ( -LRB- cord-010092-uftc8inx 4482 23 2 2 LS cord-010092-uftc8inx 4482 24 ) ) -RRB- cord-010092-uftc8inx 4482 25 designing design VBG cord-010092-uftc8inx 4482 26 a a DT cord-010092-uftc8inx 4482 27 structured structured JJ cord-010092-uftc8inx 4482 28 order order NN cord-010092-uftc8inx 4482 29 entry entry NN cord-010092-uftc8inx 4482 30 ; ; , cord-010092-uftc8inx 4482 31 ( ( -LRB- cord-010092-uftc8inx 4482 32 3 3 LS cord-010092-uftc8inx 4482 33 ) ) -RRB- cord-010092-uftc8inx 4482 34 proactively proactively RB cord-010092-uftc8inx 4482 35 reminding remind VBG cord-010092-uftc8inx 4482 36 the the DT cord-010092-uftc8inx 4482 37 physicians physician NNS cord-010092-uftc8inx 4482 38 with with IN cord-010092-uftc8inx 4482 39 patient patient NN cord-010092-uftc8inx 4482 40 's 's POS cord-010092-uftc8inx 4482 41 previous previous JJ cord-010092-uftc8inx 4482 42 blood blood NN cord-010092-uftc8inx 4482 43 transfusion transfusion NN cord-010092-uftc8inx 4482 44 reaction reaction NN cord-010092-uftc8inx 4482 45 with with IN cord-010092-uftc8inx 4482 46 related related JJ cord-010092-uftc8inx 4482 47 precautions precaution NNS cord-010092-uftc8inx 4482 48 including include VBG cord-010092-uftc8inx 4482 49 the the DT cord-010092-uftc8inx 4482 50 use use NN cord-010092-uftc8inx 4482 51 of of IN cord-010092-uftc8inx 4482 52 leukoreduction leukoreduction NN cord-010092-uftc8inx 4482 53 filter filter NN cord-010092-uftc8inx 4482 54 ; ; , cord-010092-uftc8inx 4482 55 ( ( -LRB- cord-010092-uftc8inx 4482 56 4 4 LS cord-010092-uftc8inx 4482 57 ) ) -RRB- cord-010092-uftc8inx 4482 58 automatically automatically RB cord-010092-uftc8inx 4482 59 reminding remind VBG cord-010092-uftc8inx 4482 60 physicians physician NNS cord-010092-uftc8inx 4482 61 the the DT cord-010092-uftc8inx 4482 62 happening happening NN cord-010092-uftc8inx 4482 63 of of IN cord-010092-uftc8inx 4482 64 reaction reaction NN cord-010092-uftc8inx 4482 65 and and CC cord-010092-uftc8inx 4482 66 suggesting suggest VBG cord-010092-uftc8inx 4482 67 relevant relevant JJ cord-010092-uftc8inx 4482 68 test test NN cord-010092-uftc8inx 4482 69 ; ; , cord-010092-uftc8inx 4482 70 ( ( -LRB- cord-010092-uftc8inx 4482 71 5 5 LS cord-010092-uftc8inx 4482 72 ) ) -RRB- cord-010092-uftc8inx 4482 73 building build VBG cord-010092-uftc8inx 4482 74 a a DT cord-010092-uftc8inx 4482 75 complete complete JJ cord-010092-uftc8inx 4482 76 traceability traceability NN cord-010092-uftc8inx 4482 77 log log NN cord-010092-uftc8inx 4482 78 system system NN cord-010092-uftc8inx 4482 79 ; ; : cord-010092-uftc8inx 4482 80 and and CC cord-010092-uftc8inx 4482 81 ( ( -LRB- cord-010092-uftc8inx 4482 82 6 6 LS cord-010092-uftc8inx 4482 83 ) ) -RRB- cord-010092-uftc8inx 4482 84 supporting support VBG cord-010092-uftc8inx 4482 85 data data NN cord-010092-uftc8inx 4482 86 analysis analysis NN cord-010092-uftc8inx 4482 87 . . . cord-010092-uftc8inx 4483 1 The the DT cord-010092-uftc8inx 4483 2 blood blood NN cord-010092-uftc8inx 4483 3 transfusion transfusion NN cord-010092-uftc8inx 4483 4 safety safety NN cord-010092-uftc8inx 4483 5 team team NN cord-010092-uftc8inx 4483 6 includes include VBZ cord-010092-uftc8inx 4483 7 medical medical JJ cord-010092-uftc8inx 4483 8 technologists technologist NNS cord-010092-uftc8inx 4483 9 , , , cord-010092-uftc8inx 4483 10 nurses nurse NNS cord-010092-uftc8inx 4483 11 , , , cord-010092-uftc8inx 4483 12 physicians physician NNS cord-010092-uftc8inx 4483 13 , , , cord-010092-uftc8inx 4483 14 system system NN cord-010092-uftc8inx 4483 15 analysts analyst NNS cord-010092-uftc8inx 4483 16 , , , cord-010092-uftc8inx 4483 17 and and CC cord-010092-uftc8inx 4483 18 blood blood NN cord-010092-uftc8inx 4483 19 transporter transporter NN cord-010092-uftc8inx 4483 20 and and CC cord-010092-uftc8inx 4483 21 the the DT cord-010092-uftc8inx 4483 22 whole whole JJ cord-010092-uftc8inx 4483 23 process process NN cord-010092-uftc8inx 4483 24 is be VBZ cord-010092-uftc8inx 4483 25 electronic electronic JJ cord-010092-uftc8inx 4483 26 management management NN cord-010092-uftc8inx 4483 27 . . . cord-010092-uftc8inx 4484 1 The the DT cord-010092-uftc8inx 4484 2 new new JJ cord-010092-uftc8inx 4484 3 blood blood NN cord-010092-uftc8inx 4484 4 transfusion transfusion NN cord-010092-uftc8inx 4484 5 platform platform NN cord-010092-uftc8inx 4484 6 integrated integrate VBD cord-010092-uftc8inx 4484 7 the the DT cord-010092-uftc8inx 4484 8 workflow workflow NN cord-010092-uftc8inx 4484 9 , , , cord-010092-uftc8inx 4484 10 reduced reduce VBD cord-010092-uftc8inx 4484 11 the the DT cord-010092-uftc8inx 4484 12 incidence incidence NN cord-010092-uftc8inx 4484 13 of of IN cord-010092-uftc8inx 4484 14 abnormal abnormal JJ cord-010092-uftc8inx 4484 15 blood blood NN cord-010092-uftc8inx 4484 16 samples sample NNS cord-010092-uftc8inx 4484 17 collected collect VBN cord-010092-uftc8inx 4484 18 ( ( -LRB- cord-010092-uftc8inx 4484 19 0 0 CD cord-010092-uftc8inx 4484 20 % % NN cord-010092-uftc8inx 4484 21 after after IN cord-010092-uftc8inx 4484 22 implementation implementation NN cord-010092-uftc8inx 4484 23 , , , cord-010092-uftc8inx 4484 24 P p NN cord-010092-uftc8inx 4484 25 < < XX cord-010092-uftc8inx 4484 26 0.01 0.01 CD cord-010092-uftc8inx 4484 27 ) ) -RRB- cord-010092-uftc8inx 4484 28 , , , cord-010092-uftc8inx 4484 29 reduced reduce VBD cord-010092-uftc8inx 4484 30 the the DT cord-010092-uftc8inx 4484 31 time time NN cord-010092-uftc8inx 4484 32 of of IN cord-010092-uftc8inx 4484 33 call call NN cord-010092-uftc8inx 4484 34 for for IN cord-010092-uftc8inx 4484 35 medical medical JJ cord-010092-uftc8inx 4484 36 technologists technologist NNS cord-010092-uftc8inx 4484 37 with with IN cord-010092-uftc8inx 4484 38 blood blood NN cord-010092-uftc8inx 4484 39 component component NN cord-010092-uftc8inx 4484 40 preparation preparation NN cord-010092-uftc8inx 4484 41 and and CC cord-010092-uftc8inx 4484 42 improved improve VBD cord-010092-uftc8inx 4484 43 the the DT cord-010092-uftc8inx 4484 44 achievement achievement NN cord-010092-uftc8inx 4484 45 rate rate NN cord-010092-uftc8inx 4484 46 of of IN cord-010092-uftc8inx 4484 47 emergency emergency NN cord-010092-uftc8inx 4484 48 30-min 30-min CD cord-010092-uftc8inx 4484 49 blood blood NN cord-010092-uftc8inx 4484 50 crossmatch crossmatch NN cord-010092-uftc8inx 4484 51 ( ( -LRB- cord-010092-uftc8inx 4484 52 98.1 98.1 CD cord-010092-uftc8inx 4484 53 % % NN cord-010092-uftc8inx 4484 54 after after IN cord-010092-uftc8inx 4484 55 implementation implementation NN cord-010092-uftc8inx 4484 56 , , , cord-010092-uftc8inx 4484 57 P p NN cord-010092-uftc8inx 4484 58 < < XX cord-010092-uftc8inx 4484 59 0.05 0.05 CD cord-010092-uftc8inx 4484 60 ) ) -RRB- cord-010092-uftc8inx 4484 61 . . . cord-010092-uftc8inx 4485 1 The the DT cord-010092-uftc8inx 4485 2 barcode barcode NN cord-010092-uftc8inx 4485 3 correctly correctly RB cord-010092-uftc8inx 4485 4 identified identify VBD cord-010092-uftc8inx 4485 5 patients patient NNS cord-010092-uftc8inx 4485 6 and and CC cord-010092-uftc8inx 4485 7 monitored monitor VBD cord-010092-uftc8inx 4485 8 the the DT cord-010092-uftc8inx 4485 9 entire entire JJ cord-010092-uftc8inx 4485 10 transfusion transfusion NN cord-010092-uftc8inx 4485 11 process process NN cord-010092-uftc8inx 4485 12 to to TO cord-010092-uftc8inx 4485 13 reduce reduce VB cord-010092-uftc8inx 4485 14 the the DT cord-010092-uftc8inx 4485 15 error error NN cord-010092-uftc8inx 4485 16 rate rate NN cord-010092-uftc8inx 4485 17 of of IN cord-010092-uftc8inx 4485 18 blood blood NN cord-010092-uftc8inx 4485 19 component component NN cord-010092-uftc8inx 4485 20 supply supply NN cord-010092-uftc8inx 4485 21 ( ( -LRB- cord-010092-uftc8inx 4485 22 0 0 CD cord-010092-uftc8inx 4485 23 % % NN cord-010092-uftc8inx 4485 24 after after IN cord-010092-uftc8inx 4485 25 implementation implementation NN cord-010092-uftc8inx 4485 26 , , , cord-010092-uftc8inx 4485 27 P p NN cord-010092-uftc8inx 4485 28 < < XX cord-010092-uftc8inx 4485 29 0.01 0.01 CD cord-010092-uftc8inx 4485 30 ) ) -RRB- cord-010092-uftc8inx 4485 31 . . . cord-010092-uftc8inx 4486 1 Summary Summary NNP cord-010092-uftc8inx 4486 2 / / SYM cord-010092-uftc8inx 4486 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 4486 4 : : : cord-010092-uftc8inx 4487 1 After after IN cord-010092-uftc8inx 4487 2 the the DT cord-010092-uftc8inx 4487 3 Transdisciplinary Transdisciplinary NNP cord-010092-uftc8inx 4487 4 Team Team NNP cord-010092-uftc8inx 4487 5 Approach Approach NNP cord-010092-uftc8inx 4487 6 with with IN cord-010092-uftc8inx 4487 7 E e NN cord-010092-uftc8inx 4487 8 - - NN cord-010092-uftc8inx 4487 9 monitoring monitoring NN cord-010092-uftc8inx 4487 10 and and CC cord-010092-uftc8inx 4487 11 a a DT cord-010092-uftc8inx 4487 12 better well JJR cord-010092-uftc8inx 4487 13 design design NN cord-010092-uftc8inx 4487 14 of of IN cord-010092-uftc8inx 4487 15 clinical clinical JJ cord-010092-uftc8inx 4487 16 decision decision NN cord-010092-uftc8inx 4487 17 support support NN cord-010092-uftc8inx 4487 18 module module NN cord-010092-uftc8inx 4487 19 with with IN cord-010092-uftc8inx 4487 20 barcode barcode NNP cord-010092-uftc8inx 4487 21 technology technology NN cord-010092-uftc8inx 4487 22 , , , cord-010092-uftc8inx 4487 23 blood blood NN cord-010092-uftc8inx 4487 24 transfusion transfusion NN cord-010092-uftc8inx 4487 25 database database NN cord-010092-uftc8inx 4487 26 platform platform NN cord-010092-uftc8inx 4487 27 improve improve VB cord-010092-uftc8inx 4487 28 the the DT cord-010092-uftc8inx 4487 29 blood blood NN cord-010092-uftc8inx 4487 30 supply supply NN cord-010092-uftc8inx 4487 31 efficiency efficiency NN cord-010092-uftc8inx 4487 32 and and CC cord-010092-uftc8inx 4487 33 assure assure VB cord-010092-uftc8inx 4487 34 blood blood NN cord-010092-uftc8inx 4487 35 transfusion transfusion NN cord-010092-uftc8inx 4487 36 safety safety NN cord-010092-uftc8inx 4487 37 . . . cord-010092-uftc8inx 4488 1 Background background NN cord-010092-uftc8inx 4488 2 : : : cord-010092-uftc8inx 4489 1 In in IN cord-010092-uftc8inx 4489 2 the the DT cord-010092-uftc8inx 4489 3 modern modern JJ cord-010092-uftc8inx 4489 4 world world NN cord-010092-uftc8inx 4489 5 , , , cord-010092-uftc8inx 4489 6 terrorist terrorist JJ cord-010092-uftc8inx 4489 7 acts act NNS cord-010092-uftc8inx 4489 8 are be VBP cord-010092-uftc8inx 4489 9 characterized characterize VBN cord-010092-uftc8inx 4489 10 by by IN cord-010092-uftc8inx 4489 11 a a DT cord-010092-uftc8inx 4489 12 multiplicity multiplicity NN cord-010092-uftc8inx 4489 13 of of IN cord-010092-uftc8inx 4489 14 combined combined JJ cord-010092-uftc8inx 4489 15 injuries injury NNS cord-010092-uftc8inx 4489 16 to to IN cord-010092-uftc8inx 4489 17 a a DT cord-010092-uftc8inx 4489 18 large large JJ cord-010092-uftc8inx 4489 19 number number NN cord-010092-uftc8inx 4489 20 of of IN cord-010092-uftc8inx 4489 21 victims victim NNS cord-010092-uftc8inx 4489 22 . . . cord-010092-uftc8inx 4490 1 Qualified qualified JJ cord-010092-uftc8inx 4490 2 medical medical JJ cord-010092-uftc8inx 4490 3 care care NN cord-010092-uftc8inx 4490 4 is be VBZ cord-010092-uftc8inx 4490 5 urgently urgently RB cord-010092-uftc8inx 4490 6 required require VBN cord-010092-uftc8inx 4490 7 for for IN cord-010092-uftc8inx 4490 8 a a DT cord-010092-uftc8inx 4490 9 large large JJ cord-010092-uftc8inx 4490 10 number number NN cord-010092-uftc8inx 4490 11 of of IN cord-010092-uftc8inx 4490 12 patients patient NNS cord-010092-uftc8inx 4490 13 in in IN cord-010092-uftc8inx 4490 14 one one CD cord-010092-uftc8inx 4490 15 locality locality NN cord-010092-uftc8inx 4490 16 at at IN cord-010092-uftc8inx 4490 17 the the DT cord-010092-uftc8inx 4490 18 same same JJ cord-010092-uftc8inx 4490 19 time time NN cord-010092-uftc8inx 4490 20 . . . cord-010092-uftc8inx 4491 1 It -PRON- PRP cord-010092-uftc8inx 4491 2 leads lead VBZ cord-010092-uftc8inx 4491 3 to to TO cord-010092-uftc8inx 4491 4 increase increase VB cord-010092-uftc8inx 4491 5 in in IN cord-010092-uftc8inx 4491 6 emergency emergency NN cord-010092-uftc8inx 4491 7 demand demand NN cord-010092-uftc8inx 4491 8 for for IN cord-010092-uftc8inx 4491 9 blood blood NN cord-010092-uftc8inx 4491 10 components component NNS cord-010092-uftc8inx 4491 11 , , , cord-010092-uftc8inx 4491 12 mostly mostly RB cord-010092-uftc8inx 4491 13 red red JJ cord-010092-uftc8inx 4491 14 blood blood NN cord-010092-uftc8inx 4491 15 cells cell NNS cord-010092-uftc8inx 4491 16 . . . cord-010092-uftc8inx 4492 1 The the DT cord-010092-uftc8inx 4492 2 desire desire NN cord-010092-uftc8inx 4492 3 to to TO cord-010092-uftc8inx 4492 4 donate donate VB cord-010092-uftc8inx 4492 5 blood blood NN cord-010092-uftc8inx 4492 6 to to IN cord-010092-uftc8inx 4492 7 the the DT cord-010092-uftc8inx 4492 8 victims victim NNS cord-010092-uftc8inx 4492 9 is be VBZ cord-010092-uftc8inx 4492 10 a a DT cord-010092-uftc8inx 4492 11 natural natural JJ cord-010092-uftc8inx 4492 12 manifestation manifestation NN cord-010092-uftc8inx 4492 13 of of IN cord-010092-uftc8inx 4492 14 society society NN cord-010092-uftc8inx 4492 15 's 's POS cord-010092-uftc8inx 4492 16 solidarity solidarity NN cord-010092-uftc8inx 4492 17 in in IN cord-010092-uftc8inx 4492 18 response response NN cord-010092-uftc8inx 4492 19 to to IN cord-010092-uftc8inx 4492 20 tragic tragic JJ cord-010092-uftc8inx 4492 21 events event NNS cord-010092-uftc8inx 4492 22 . . . cord-010092-uftc8inx 4493 1 However however RB cord-010092-uftc8inx 4493 2 , , , cord-010092-uftc8inx 4493 3 donor donor NN cord-010092-uftc8inx 4493 4 activity activity NN cord-010092-uftc8inx 4493 5 and and CC cord-010092-uftc8inx 4493 6 patient patient NN cord-010092-uftc8inx 4493 7 needs need NNS cord-010092-uftc8inx 4493 8 do do VBP cord-010092-uftc8inx 4493 9 not not RB cord-010092-uftc8inx 4493 10 always always RB cord-010092-uftc8inx 4493 11 correlate correlate VB cord-010092-uftc8inx 4493 12 . . . cord-010092-uftc8inx 4494 1 Aims aim VBZ cord-010092-uftc8inx 4494 2 : : : cord-010092-uftc8inx 4494 3 To to TO cord-010092-uftc8inx 4494 4 analyze analyze VB cord-010092-uftc8inx 4494 5 the the DT cord-010092-uftc8inx 4494 6 donor donor NN cord-010092-uftc8inx 4494 7 activity activity NN cord-010092-uftc8inx 4494 8 during during IN cord-010092-uftc8inx 4494 9 the the DT cord-010092-uftc8inx 4494 10 terrorist terrorist JJ cord-010092-uftc8inx 4494 11 attacks attack NNS cord-010092-uftc8inx 4494 12 . . . cord-010092-uftc8inx 4495 1 Methods method NNS cord-010092-uftc8inx 4495 2 : : : cord-010092-uftc8inx 4496 1 A a DT cord-010092-uftc8inx 4496 2 retrospective retrospective JJ cord-010092-uftc8inx 4496 3 analysis analysis NN cord-010092-uftc8inx 4496 4 of of IN cord-010092-uftc8inx 4496 5 donation donation NN cord-010092-uftc8inx 4496 6 activity activity NN cord-010092-uftc8inx 4496 7 in in IN cord-010092-uftc8inx 4496 8 periods period NNS cord-010092-uftc8inx 4496 9 of of IN cord-010092-uftc8inx 4496 10 terrorist terrorist JJ cord-010092-uftc8inx 4496 11 attacks attack NNS cord-010092-uftc8inx 4496 12 in in IN cord-010092-uftc8inx 4496 13 Moscow Moscow NNP cord-010092-uftc8inx 4496 14 ( ( -LRB- cord-010092-uftc8inx 4497 1 2004 2004 CD cord-010092-uftc8inx 4497 2 Moscow Moscow NNP cord-010092-uftc8inx 4497 3 ( ( -LRB- cord-010092-uftc8inx 4497 4 -2011 -2011 NN cord-010092-uftc8inx 4497 5 . . . cord-010092-uftc8inx 4498 1 The the DT cord-010092-uftc8inx 4498 2 average average JJ cord-010092-uftc8inx 4498 3 daily daily JJ cord-010092-uftc8inx 4498 4 blood blood NN cord-010092-uftc8inx 4498 5 donations donation NNS cord-010092-uftc8inx 4498 6 ' ' POS cord-010092-uftc8inx 4498 7 number number NN cord-010092-uftc8inx 4498 8 ( ( -LRB- cord-010092-uftc8inx 4498 9 DBDN DBDN NNP cord-010092-uftc8inx 4498 10 ) ) -RRB- cord-010092-uftc8inx 4498 11 before before IN cord-010092-uftc8inx 4498 12 TA TA NNP cord-010092-uftc8inx 4498 13 compared compare VBN cord-010092-uftc8inx 4498 14 with with IN cord-010092-uftc8inx 4498 15 the the DT cord-010092-uftc8inx 4498 16 number number NN cord-010092-uftc8inx 4498 17 of of IN cord-010092-uftc8inx 4498 18 donations donation NNS cord-010092-uftc8inx 4498 19 in in IN cord-010092-uftc8inx 4498 20 day day NN cord-010092-uftc8inx 4498 21 after after IN cord-010092-uftc8inx 4498 22 TA TA NNP cord-010092-uftc8inx 4498 23 and and CC cord-010092-uftc8inx 4498 24 with with IN cord-010092-uftc8inx 4498 25 the the DT cord-010092-uftc8inx 4498 26 DBDN DBDN NNP cord-010092-uftc8inx 4498 27 during during IN cord-010092-uftc8inx 4498 28 7 7 CD cord-010092-uftc8inx 4498 29 days day NNS cord-010092-uftc8inx 4498 30 after after IN cord-010092-uftc8inx 4498 31 TA TA NNP cord-010092-uftc8inx 4498 32 . . . cord-010092-uftc8inx 4499 1 Also also RB cord-010092-uftc8inx 4499 2 the the DT cord-010092-uftc8inx 4499 3 number number NN cord-010092-uftc8inx 4499 4 of of IN cord-010092-uftc8inx 4499 5 delivered deliver VBN cord-010092-uftc8inx 4499 6 RBC RBC NNP cord-010092-uftc8inx 4499 7 units unit NNS cord-010092-uftc8inx 4499 8 ( ( -LRB- cord-010092-uftc8inx 4499 9 D D NNP cord-010092-uftc8inx 4499 10 - - HYPH cord-010092-uftc8inx 4499 11 RBCU rbcu JJ cord-010092-uftc8inx 4499 12 ) ) -RRB- cord-010092-uftc8inx 4499 13 daily daily RB cord-010092-uftc8inx 4499 14 before before IN cord-010092-uftc8inx 4499 15 TA TA NNP cord-010092-uftc8inx 4499 16 and and CC cord-010092-uftc8inx 4499 17 daily daily RB cord-010092-uftc8inx 4499 18 in in IN cord-010092-uftc8inx 4499 19 7 7 CD cord-010092-uftc8inx 4499 20 days day NNS cord-010092-uftc8inx 4499 21 after after RB cord-010092-uftc8inx 4499 22 were be VBD cord-010092-uftc8inx 4499 23 compared compare VBN cord-010092-uftc8inx 4499 24 . . . cord-010092-uftc8inx 4500 1 Results result NNS cord-010092-uftc8inx 4500 2 : : : cord-010092-uftc8inx 4501 1 In in IN cord-010092-uftc8inx 4501 2 2004 2004 CD cord-010092-uftc8inx 4501 3 - - SYM cord-010092-uftc8inx 4501 4 2011 2011 CD cord-010092-uftc8inx 4501 5 , , , cord-010092-uftc8inx 4501 6 5 5 CD cord-010092-uftc8inx 4501 7 terrible terrible JJ cord-010092-uftc8inx 4501 8 TA TA NNP cord-010092-uftc8inx 4501 9 occurred occur VBD cord-010092-uftc8inx 4501 10 in in IN cord-010092-uftc8inx 4501 11 Moscow Moscow NNP cord-010092-uftc8inx 4501 12 : : : cord-010092-uftc8inx 4501 13 141 141 CD cord-010092-uftc8inx 4501 14 people people NNS cord-010092-uftc8inx 4501 15 died die VBD cord-010092-uftc8inx 4501 16 and and CC cord-010092-uftc8inx 4501 17 more more JJR cord-010092-uftc8inx 4501 18 than than IN cord-010092-uftc8inx 4501 19 629 629 CD cord-010092-uftc8inx 4501 20 were be VBD cord-010092-uftc8inx 4501 21 injured injure VBN cord-010092-uftc8inx 4501 22 . . . cord-010092-uftc8inx 4502 1 With with IN cord-010092-uftc8inx 4502 2 the the DT cord-010092-uftc8inx 4502 3 explosion explosion NN cord-010092-uftc8inx 4502 4 in in IN cord-010092-uftc8inx 4502 5 subway subway NN cord-010092-uftc8inx 4502 6 in in IN cord-010092-uftc8inx 4502 7 02/2004 02/2004 CD cord-010092-uftc8inx 4502 8 42 42 CD cord-010092-uftc8inx 4502 9 people people NNS cord-010092-uftc8inx 4502 10 died die VBD cord-010092-uftc8inx 4502 11 , , , cord-010092-uftc8inx 4502 12 250 250 CD cord-010092-uftc8inx 4502 13 were be VBD cord-010092-uftc8inx 4502 14 injured injure VBN cord-010092-uftc8inx 4502 15 . . . cord-010092-uftc8inx 4503 1 The the DT cord-010092-uftc8inx 4503 2 number number NN cord-010092-uftc8inx 4503 3 of of IN cord-010092-uftc8inx 4503 4 D d NN cord-010092-uftc8inx 4503 5 - - HYPH cord-010092-uftc8inx 4503 6 RBCUs rbcus NN cord-010092-uftc8inx 4503 7 increased increase VBN cord-010092-uftc8inx 4503 8 by by IN cord-010092-uftc8inx 4503 9 10 10 CD cord-010092-uftc8inx 4503 10 % % NN cord-010092-uftc8inx 4503 11 on on IN cord-010092-uftc8inx 4503 12 TA TA NNP cord-010092-uftc8inx 4503 13 - - HYPH cord-010092-uftc8inx 4503 14 day day NN cord-010092-uftc8inx 4503 15 , , , cord-010092-uftc8inx 4503 16 and and CC cord-010092-uftc8inx 4503 17 by by IN cord-010092-uftc8inx 4503 18 30 30 CD cord-010092-uftc8inx 4503 19 % % NN cord-010092-uftc8inx 4503 20 during during IN cord-010092-uftc8inx 4503 21 next next JJ cord-010092-uftc8inx 4503 22 7 7 CD cord-010092-uftc8inx 4503 23 days day NNS cord-010092-uftc8inx 4503 24 . . . cord-010092-uftc8inx 4504 1 DBDN DBDN NNP cord-010092-uftc8inx 4504 2 in in IN cord-010092-uftc8inx 4504 3 the the DT cord-010092-uftc8inx 4504 4 1st 1st JJ cord-010092-uftc8inx 4504 5 day day NN cord-010092-uftc8inx 4504 6 after after IN cord-010092-uftc8inx 4504 7 TA TA NNP cord-010092-uftc8inx 4504 8 increased increase VBD cord-010092-uftc8inx 4504 9 6,7 6,7 CD cord-010092-uftc8inx 4504 10 times time NNS cord-010092-uftc8inx 4504 11 , , , cord-010092-uftc8inx 4504 12 and and CC cord-010092-uftc8inx 4504 13 in in IN cord-010092-uftc8inx 4504 14 the the DT cord-010092-uftc8inx 4504 15 next next JJ cord-010092-uftc8inx 4504 16 7 7 CD cord-010092-uftc8inx 4504 17 days day NNS cord-010092-uftc8inx 4504 18 -1,6 -1,6 NNP cord-010092-uftc8inx 4504 19 times time NNS cord-010092-uftc8inx 4504 20 . . . cord-010092-uftc8inx 4505 1 Second second JJ cord-010092-uftc8inx 4505 2 explosion explosion NN cord-010092-uftc8inx 4505 3 in in IN cord-010092-uftc8inx 4505 4 subway subway NN cord-010092-uftc8inx 4505 5 in in IN cord-010092-uftc8inx 4505 6 08/2004 08/2004 CD cord-010092-uftc8inx 4505 7 resulted result VBD cord-010092-uftc8inx 4505 8 in in IN cord-010092-uftc8inx 4505 9 10 10 CD cord-010092-uftc8inx 4505 10 died die VBD cord-010092-uftc8inx 4505 11 , , , cord-010092-uftc8inx 4505 12 50 50 CD cord-010092-uftc8inx 4505 13 injured injure VBN cord-010092-uftc8inx 4505 14 . . . cord-010092-uftc8inx 4506 1 The the DT cord-010092-uftc8inx 4506 2 number number NN cord-010092-uftc8inx 4506 3 of of IN cord-010092-uftc8inx 4506 4 D d NN cord-010092-uftc8inx 4506 5 - - HYPH cord-010092-uftc8inx 4506 6 RBCUs rbcus NN cord-010092-uftc8inx 4506 7 increased increase VBN cord-010092-uftc8inx 4506 8 by by IN cord-010092-uftc8inx 4506 9 80 80 CD cord-010092-uftc8inx 4506 10 % % NN cord-010092-uftc8inx 4506 11 on on IN cord-010092-uftc8inx 4506 12 TA TA NNP cord-010092-uftc8inx 4506 13 - - HYPH cord-010092-uftc8inx 4506 14 day day NN cord-010092-uftc8inx 4506 15 , , , cord-010092-uftc8inx 4506 16 and and CC cord-010092-uftc8inx 4506 17 by by IN cord-010092-uftc8inx 4506 18 0 0 CD cord-010092-uftc8inx 4506 19 % % NN cord-010092-uftc8inx 4506 20 during during IN cord-010092-uftc8inx 4506 21 7 7 CD cord-010092-uftc8inx 4506 22 days day NNS cord-010092-uftc8inx 4506 23 . . . cord-010092-uftc8inx 4507 1 DBDN DBDN NNP cord-010092-uftc8inx 4507 2 in in IN cord-010092-uftc8inx 4507 3 the the DT cord-010092-uftc8inx 4507 4 1st 1st JJ cord-010092-uftc8inx 4507 5 day day NN cord-010092-uftc8inx 4507 6 after after IN cord-010092-uftc8inx 4507 7 TA TA NNP cord-010092-uftc8inx 4507 8 increased increase VBD cord-010092-uftc8inx 4507 9 1,1 1,1 CD cord-010092-uftc8inx 4507 10 times time NNS cord-010092-uftc8inx 4507 11 , , , cord-010092-uftc8inx 4507 12 and and CC cord-010092-uftc8inx 4507 13 in in IN cord-010092-uftc8inx 4507 14 the the DT cord-010092-uftc8inx 4507 15 next next JJ cord-010092-uftc8inx 4507 16 7 7 CD cord-010092-uftc8inx 4507 17 days day NNS cord-010092-uftc8inx 4507 18 -2,2 -2,2 VBP cord-010092-uftc8inx 4507 19 times time NNS cord-010092-uftc8inx 4507 20 . . . cord-010092-uftc8inx 4508 1 In in IN cord-010092-uftc8inx 4508 2 2006 2006 CD cord-010092-uftc8inx 4508 3 ( ( -LRB- cord-010092-uftc8inx 4508 4 explosion explosion NN cord-010092-uftc8inx 4508 5 on on IN cord-010092-uftc8inx 4508 6 market market NN cord-010092-uftc8inx 4508 7 ) ) -RRB- cord-010092-uftc8inx 4508 8 resulted result VBD cord-010092-uftc8inx 4508 9 in in IN cord-010092-uftc8inx 4508 10 14 14 CD cord-010092-uftc8inx 4508 11 died die VBD cord-010092-uftc8inx 4508 12 , , , cord-010092-uftc8inx 4508 13 61 61 CD cord-010092-uftc8inx 4508 14 injured injure VBN cord-010092-uftc8inx 4508 15 . . . cord-010092-uftc8inx 4509 1 D D NNP cord-010092-uftc8inx 4509 2 - - HYPH cord-010092-uftc8inx 4509 3 RBCUs rbcus NN cord-010092-uftc8inx 4509 4 delivery delivery NN cord-010092-uftc8inx 4509 5 increased increase VBN cord-010092-uftc8inx 4509 6 by by IN cord-010092-uftc8inx 4509 7 20 20 CD cord-010092-uftc8inx 4509 8 % % NN cord-010092-uftc8inx 4509 9 on on IN cord-010092-uftc8inx 4509 10 TA TA NNP cord-010092-uftc8inx 4509 11 - - HYPH cord-010092-uftc8inx 4509 12 day day NN cord-010092-uftc8inx 4509 13 , , , cord-010092-uftc8inx 4509 14 and and CC cord-010092-uftc8inx 4509 15 by by IN cord-010092-uftc8inx 4509 16 10 10 CD cord-010092-uftc8inx 4509 17 % % NN cord-010092-uftc8inx 4509 18 during during IN cord-010092-uftc8inx 4509 19 7 7 CD cord-010092-uftc8inx 4509 20 days day NNS cord-010092-uftc8inx 4509 21 . . . cord-010092-uftc8inx 4510 1 DBDN DBDN NNP cord-010092-uftc8inx 4510 2 in in IN cord-010092-uftc8inx 4510 3 the the DT cord-010092-uftc8inx 4510 4 1st 1st JJ cord-010092-uftc8inx 4510 5 day day NN cord-010092-uftc8inx 4510 6 increased increase VBD cord-010092-uftc8inx 4510 7 2,0 2,0 CD cord-010092-uftc8inx 4510 8 times time NNS cord-010092-uftc8inx 4510 9 , , , cord-010092-uftc8inx 4510 10 but but CC cord-010092-uftc8inx 4510 11 decreased decrease VBD cord-010092-uftc8inx 4510 12 to to IN cord-010092-uftc8inx 4510 13 0,6 0,6 CD cord-010092-uftc8inx 4510 14 times time NNS cord-010092-uftc8inx 4510 15 during during IN cord-010092-uftc8inx 4510 16 the the DT cord-010092-uftc8inx 4510 17 next next JJ cord-010092-uftc8inx 4510 18 week week NN cord-010092-uftc8inx 4510 19 . . . cord-010092-uftc8inx 4511 1 With with IN cord-010092-uftc8inx 4511 2 subway subway NN cord-010092-uftc8inx 4511 3 explosion explosion NN cord-010092-uftc8inx 4511 4 in in IN cord-010092-uftc8inx 4511 5 2010 2010 CD cord-010092-uftc8inx 4511 6 40 40 CD cord-010092-uftc8inx 4511 7 people people NNS cord-010092-uftc8inx 4511 8 died die VBD cord-010092-uftc8inx 4511 9 , , , cord-010092-uftc8inx 4511 10 88 88 CD cord-010092-uftc8inx 4511 11 were be VBD cord-010092-uftc8inx 4511 12 injured injure VBN cord-010092-uftc8inx 4511 13 . . . cord-010092-uftc8inx 4512 1 The the DT cord-010092-uftc8inx 4512 2 number number NN cord-010092-uftc8inx 4512 3 of of IN cord-010092-uftc8inx 4512 4 D d NN cord-010092-uftc8inx 4512 5 - - HYPH cord-010092-uftc8inx 4512 6 RBCUs rbcus NN cord-010092-uftc8inx 4512 7 increased increase VBN cord-010092-uftc8inx 4512 8 by by IN cord-010092-uftc8inx 4512 9 10 10 CD cord-010092-uftc8inx 4512 10 % % NN cord-010092-uftc8inx 4512 11 on on IN cord-010092-uftc8inx 4512 12 TA TA NNP cord-010092-uftc8inx 4512 13 - - HYPH cord-010092-uftc8inx 4512 14 day day NN cord-010092-uftc8inx 4512 15 , , , cord-010092-uftc8inx 4512 16 and and CC cord-010092-uftc8inx 4512 17 by by IN cord-010092-uftc8inx 4512 18 0 0 CD cord-010092-uftc8inx 4512 19 % % NN cord-010092-uftc8inx 4512 20 during during IN cord-010092-uftc8inx 4512 21 7 7 CD cord-010092-uftc8inx 4512 22 days day NNS cord-010092-uftc8inx 4512 23 . . . cord-010092-uftc8inx 4513 1 DBDN DBDN NNP cord-010092-uftc8inx 4513 2 in in IN cord-010092-uftc8inx 4513 3 the the DT cord-010092-uftc8inx 4513 4 1st 1st JJ cord-010092-uftc8inx 4513 5 day day NN cord-010092-uftc8inx 4513 6 after after IN cord-010092-uftc8inx 4513 7 TA TA NNP cord-010092-uftc8inx 4513 8 increased increase VBD cord-010092-uftc8inx 4513 9 6,5 6,5 CD cord-010092-uftc8inx 4513 10 times time NNS cord-010092-uftc8inx 4513 11 , , , cord-010092-uftc8inx 4513 12 and and CC cord-010092-uftc8inx 4513 13 in in IN cord-010092-uftc8inx 4513 14 the the DT cord-010092-uftc8inx 4513 15 next next JJ cord-010092-uftc8inx 4513 16 7 7 CD cord-010092-uftc8inx 4513 17 days day NNS cord-010092-uftc8inx 4513 18 -1,6 -1,6 NNP cord-010092-uftc8inx 4513 19 times time NNS cord-010092-uftc8inx 4513 20 . . . cord-010092-uftc8inx 4514 1 With with IN cord-010092-uftc8inx 4514 2 the the DT cord-010092-uftc8inx 4514 3 explosion explosion NN cord-010092-uftc8inx 4514 4 in in IN cord-010092-uftc8inx 4514 5 airport airport NN cord-010092-uftc8inx 4514 6 in in IN cord-010092-uftc8inx 4514 7 2011 2011 CD cord-010092-uftc8inx 4514 8 35 35 CD cord-010092-uftc8inx 4514 9 people people NNS cord-010092-uftc8inx 4514 10 died die VBD cord-010092-uftc8inx 4514 11 , , , cord-010092-uftc8inx 4514 12 180 180 CD cord-010092-uftc8inx 4514 13 were be VBD cord-010092-uftc8inx 4514 14 injured injure VBN cord-010092-uftc8inx 4514 15 . . . cord-010092-uftc8inx 4515 1 RBCUs RBCUs NNP cord-010092-uftc8inx 4515 2 delivery delivery NN cord-010092-uftc8inx 4515 3 increased increase VBD cord-010092-uftc8inx 4515 4 by by IN cord-010092-uftc8inx 4515 5 50 50 CD cord-010092-uftc8inx 4515 6 % % NN cord-010092-uftc8inx 4515 7 on on IN cord-010092-uftc8inx 4515 8 TA TA NNP cord-010092-uftc8inx 4515 9 - - HYPH cord-010092-uftc8inx 4515 10 day day NN cord-010092-uftc8inx 4515 11 , , , cord-010092-uftc8inx 4515 12 and and CC cord-010092-uftc8inx 4515 13 by by IN cord-010092-uftc8inx 4515 14 40 40 CD cord-010092-uftc8inx 4515 15 % % NN cord-010092-uftc8inx 4515 16 during during IN cord-010092-uftc8inx 4515 17 next next JJ cord-010092-uftc8inx 4515 18 7 7 CD cord-010092-uftc8inx 4515 19 days day NNS cord-010092-uftc8inx 4515 20 . . . cord-010092-uftc8inx 4516 1 DBDN DBDN NNP cord-010092-uftc8inx 4516 2 in in IN cord-010092-uftc8inx 4516 3 the the DT cord-010092-uftc8inx 4516 4 1st 1st JJ cord-010092-uftc8inx 4516 5 day day NN cord-010092-uftc8inx 4516 6 after after IN cord-010092-uftc8inx 4516 7 TA TA NNP cord-010092-uftc8inx 4516 8 increased increase VBD cord-010092-uftc8inx 4516 9 6,1 6,1 CD cord-010092-uftc8inx 4516 10 times time NNS cord-010092-uftc8inx 4516 11 , , , cord-010092-uftc8inx 4516 12 and and CC cord-010092-uftc8inx 4516 13 in in IN cord-010092-uftc8inx 4516 14 the the DT cord-010092-uftc8inx 4516 15 next next JJ cord-010092-uftc8inx 4516 16 7 7 CD cord-010092-uftc8inx 4516 17 days day NNS cord-010092-uftc8inx 4516 18 -2,0 -2,0 DT cord-010092-uftc8inx 4516 19 times time NNS cord-010092-uftc8inx 4516 20 . . . cord-010092-uftc8inx 4517 1 Summary Summary NNP cord-010092-uftc8inx 4517 2 / / SYM cord-010092-uftc8inx 4517 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 4517 4 : : : cord-010092-uftc8inx 4518 1 An an DT cord-010092-uftc8inx 4518 2 increase increase NN cord-010092-uftc8inx 4518 3 in in IN cord-010092-uftc8inx 4518 4 donor donor NN cord-010092-uftc8inx 4518 5 activity activity NN cord-010092-uftc8inx 4518 6 is be VBZ cord-010092-uftc8inx 4518 7 observed observe VBN cord-010092-uftc8inx 4518 8 already already RB cord-010092-uftc8inx 4518 9 the the DT cord-010092-uftc8inx 4518 10 next next JJ cord-010092-uftc8inx 4518 11 day day NN cord-010092-uftc8inx 4518 12 after after IN cord-010092-uftc8inx 4518 13 TA TA NNP cord-010092-uftc8inx 4518 14 and and CC cord-010092-uftc8inx 4518 15 usually usually RB cord-010092-uftc8inx 4518 16 lasts last VBZ cord-010092-uftc8inx 4518 17 for for IN cord-010092-uftc8inx 4518 18 7 7 CD cord-010092-uftc8inx 4518 19 days day NNS cord-010092-uftc8inx 4518 20 , , , cord-010092-uftc8inx 4518 21 but but CC cord-010092-uftc8inx 4518 22 does do VBZ cord-010092-uftc8inx 4518 23 not not RB cord-010092-uftc8inx 4518 24 correlate correlate VB cord-010092-uftc8inx 4518 25 with with IN cord-010092-uftc8inx 4518 26 the the DT cord-010092-uftc8inx 4518 27 number number NN cord-010092-uftc8inx 4518 28 of of IN cord-010092-uftc8inx 4518 29 victims victim NNS cord-010092-uftc8inx 4518 30 . . . cord-010092-uftc8inx 4519 1 The the DT cord-010092-uftc8inx 4519 2 RBCs rbc NNS cord-010092-uftc8inx 4519 3 ' ' POS cord-010092-uftc8inx 4519 4 delivery delivery NN cord-010092-uftc8inx 4519 5 from from IN cord-010092-uftc8inx 4519 6 blood blood NN cord-010092-uftc8inx 4519 7 bank bank NN cord-010092-uftc8inx 4519 8 increases increase NNS cord-010092-uftc8inx 4519 9 in in IN cord-010092-uftc8inx 4519 10 all all DT cord-010092-uftc8inx 4519 11 cases case NNS cord-010092-uftc8inx 4519 12 on on IN cord-010092-uftc8inx 4519 13 the the DT cord-010092-uftc8inx 4519 14 day day NN cord-010092-uftc8inx 4519 15 of of IN cord-010092-uftc8inx 4519 16 the the DT cord-010092-uftc8inx 4519 17 TA TA NNP cord-010092-uftc8inx 4519 18 . . . cord-010092-uftc8inx 4520 1 Therefore therefore RB cord-010092-uftc8inx 4520 2 , , , cord-010092-uftc8inx 4520 3 the the DT cord-010092-uftc8inx 4520 4 guarantee guarantee NN cord-010092-uftc8inx 4520 5 for for IN cord-010092-uftc8inx 4520 6 patients patient NNS cord-010092-uftc8inx 4520 7 is be VBZ cord-010092-uftc8inx 4520 8 the the DT cord-010092-uftc8inx 4520 9 maintenance maintenance NN cord-010092-uftc8inx 4520 10 of of IN cord-010092-uftc8inx 4520 11 RBCs rbc NNS cord-010092-uftc8inx 4520 12 ' ' POS cord-010092-uftc8inx 4520 13 stock stock NN cord-010092-uftc8inx 4520 14 , , , cord-010092-uftc8inx 4520 15 including include VBG cord-010092-uftc8inx 4520 16 cryopreserved cryopreserved JJ cord-010092-uftc8inx 4520 17 ones one NNS cord-010092-uftc8inx 4520 18 . . . cord-010092-uftc8inx 4521 1 It -PRON- PRP cord-010092-uftc8inx 4521 2 is be VBZ cord-010092-uftc8inx 4521 3 also also RB cord-010092-uftc8inx 4521 4 necessary necessary JJ cord-010092-uftc8inx 4521 5 to to TO cord-010092-uftc8inx 4521 6 promptly promptly RB cord-010092-uftc8inx 4521 7 send send VB cord-010092-uftc8inx 4521 8 excess excess NN cord-010092-uftc8inx 4521 9 of of IN cord-010092-uftc8inx 4521 10 red red JJ cord-010092-uftc8inx 4521 11 blood blood NN cord-010092-uftc8inx 4521 12 cells cell NNS cord-010092-uftc8inx 4521 13 harvested harvest VBN cord-010092-uftc8inx 4521 14 at at IN cord-010092-uftc8inx 4521 15 the the DT cord-010092-uftc8inx 4521 16 peak peak NN cord-010092-uftc8inx 4521 17 of of IN cord-010092-uftc8inx 4521 18 activity activity NN cord-010092-uftc8inx 4521 19 to to IN cord-010092-uftc8inx 4521 20 the the DT cord-010092-uftc8inx 4521 21 cryobank cryobank NN cord-010092-uftc8inx 4521 22 . . . cord-010092-uftc8inx 4522 1 Background background NN cord-010092-uftc8inx 4522 2 : : : cord-010092-uftc8inx 4523 1 Rh Rh NNP cord-010092-uftc8inx 4523 2 system system NN cord-010092-uftc8inx 4523 3 is be VBZ cord-010092-uftc8inx 4523 4 the the DT cord-010092-uftc8inx 4523 5 major major JJ cord-010092-uftc8inx 4523 6 blood blood NN cord-010092-uftc8inx 4523 7 group group NN cord-010092-uftc8inx 4523 8 system system NN cord-010092-uftc8inx 4523 9 besides besides IN cord-010092-uftc8inx 4523 10 ABO ABO NNP cord-010092-uftc8inx 4523 11 system system NN cord-010092-uftc8inx 4523 12 . . . cord-010092-uftc8inx 4524 1 Even even RB cord-010092-uftc8inx 4524 2 after after IN cord-010092-uftc8inx 4524 3 proper proper JJ cord-010092-uftc8inx 4524 4 blood blood NN cord-010092-uftc8inx 4524 5 grouping grouping NN cord-010092-uftc8inx 4524 6 and and CC cord-010092-uftc8inx 4524 7 cross cross NN cord-010092-uftc8inx 4524 8 matching matching NN cord-010092-uftc8inx 4524 9 there there EX cord-010092-uftc8inx 4524 10 is be VBZ cord-010092-uftc8inx 4524 11 a a DT cord-010092-uftc8inx 4524 12 possibility possibility NN cord-010092-uftc8inx 4524 13 of of IN cord-010092-uftc8inx 4524 14 alloimmunisation alloimmunisation NN cord-010092-uftc8inx 4524 15 in in IN cord-010092-uftc8inx 4524 16 recipients recipient NNS cord-010092-uftc8inx 4524 17 against against IN cord-010092-uftc8inx 4524 18 the the DT cord-010092-uftc8inx 4524 19 Rh Rh NNP cord-010092-uftc8inx 4524 20 or or CC cord-010092-uftc8inx 4524 21 minor minor JJ cord-010092-uftc8inx 4524 22 blood blood NN cord-010092-uftc8inx 4524 23 group group NN cord-010092-uftc8inx 4524 24 antigens antigen NNS cord-010092-uftc8inx 4524 25 like like IN cord-010092-uftc8inx 4524 26 Kell Kell NNP cord-010092-uftc8inx 4524 27 , , , cord-010092-uftc8inx 4524 28 MNSs mns NNS cord-010092-uftc8inx 4524 29 , , , cord-010092-uftc8inx 4524 30 Duffy Duffy NNP cord-010092-uftc8inx 4524 31 etc etc FW cord-010092-uftc8inx 4524 32 . . . cord-010092-uftc8inx 4525 1 In in IN cord-010092-uftc8inx 4525 2 medical medical JJ cord-010092-uftc8inx 4525 3 colleges college NNS cord-010092-uftc8inx 4525 4 which which WDT cord-010092-uftc8inx 4525 5 can can MD cord-010092-uftc8inx 4525 6 not not RB cord-010092-uftc8inx 4525 7 bear bear VB cord-010092-uftc8inx 4525 8 the the DT cord-010092-uftc8inx 4525 9 financial financial JJ cord-010092-uftc8inx 4525 10 burden burden NN cord-010092-uftc8inx 4525 11 of of IN cord-010092-uftc8inx 4525 12 complete complete JJ cord-010092-uftc8inx 4525 13 Phenotyping phenotyping NN cord-010092-uftc8inx 4525 14 of of IN cord-010092-uftc8inx 4525 15 patient patient NN cord-010092-uftc8inx 4525 16 and and CC cord-010092-uftc8inx 4525 17 donor donor NN cord-010092-uftc8inx 4525 18 , , , cord-010092-uftc8inx 4525 19 implementation implementation NN cord-010092-uftc8inx 4525 20 of of IN cord-010092-uftc8inx 4525 21 Rh Rh NNP cord-010092-uftc8inx 4525 22 & & CC cord-010092-uftc8inx 4525 23 Kell Kell NNP cord-010092-uftc8inx 4525 24 phenotypes phenotype NNS cord-010092-uftc8inx 4525 25 match match VBP cord-010092-uftc8inx 4525 26 blood blood NN cord-010092-uftc8inx 4525 27 transfusion transfusion NN cord-010092-uftc8inx 4525 28 can can MD cord-010092-uftc8inx 4525 29 play play VB cord-010092-uftc8inx 4525 30 a a DT cord-010092-uftc8inx 4525 31 major major JJ cord-010092-uftc8inx 4525 32 role role NN cord-010092-uftc8inx 4525 33 in in IN cord-010092-uftc8inx 4525 34 preventing prevent VBG cord-010092-uftc8inx 4525 35 alloimmunisation alloimmunisation NN cord-010092-uftc8inx 4525 36 and and CC cord-010092-uftc8inx 4525 37 adverse adverse JJ cord-010092-uftc8inx 4525 38 events event NNS cord-010092-uftc8inx 4525 39 in in IN cord-010092-uftc8inx 4525 40 multitransfusion multitransfusion NN cord-010092-uftc8inx 4525 41 patients patient NNS cord-010092-uftc8inx 4526 1 Aims aim VBZ cord-010092-uftc8inx 4526 2 : : : cord-010092-uftc8inx 4526 3 To to TO cord-010092-uftc8inx 4526 4 evaluate evaluate VB cord-010092-uftc8inx 4526 5 the the DT cord-010092-uftc8inx 4526 6 efficacy efficacy NN cord-010092-uftc8inx 4526 7 of of IN cord-010092-uftc8inx 4526 8 Rh Rh NNP cord-010092-uftc8inx 4526 9 & & CC cord-010092-uftc8inx 4526 10 Kell Kell NNP cord-010092-uftc8inx 4526 11 phenotyping phenotyping NN cord-010092-uftc8inx 4526 12 as as IN cord-010092-uftc8inx 4526 13 a a DT cord-010092-uftc8inx 4526 14 cost cost NN cord-010092-uftc8inx 4526 15 effective effective JJ cord-010092-uftc8inx 4526 16 measure measure NN cord-010092-uftc8inx 4526 17 instead instead RB cord-010092-uftc8inx 4526 18 of of IN cord-010092-uftc8inx 4526 19 extended extended JJ cord-010092-uftc8inx 4526 20 phenotyping phenotyping NN cord-010092-uftc8inx 4526 21 in in IN cord-010092-uftc8inx 4526 22 multitransfused multitransfuse VBN cord-010092-uftc8inx 4526 23 patients patient NNS cord-010092-uftc8inx 4526 24 Methods method NNS cord-010092-uftc8inx 4526 25 : : : cord-010092-uftc8inx 4526 26 Study Study NNP cord-010092-uftc8inx 4526 27 was be VBD cord-010092-uftc8inx 4526 28 carried carry VBN cord-010092-uftc8inx 4526 29 out out RP cord-010092-uftc8inx 4526 30 in in IN cord-010092-uftc8inx 4526 31 the the DT cord-010092-uftc8inx 4526 32 Department Department NNP cord-010092-uftc8inx 4526 33 of of IN cord-010092-uftc8inx 4526 34 Transfusion Transfusion NNP cord-010092-uftc8inx 4526 35 Medicine Medicine NNP cord-010092-uftc8inx 4526 36 , , , cord-010092-uftc8inx 4526 37 one one CD cord-010092-uftc8inx 4526 38 of of IN cord-010092-uftc8inx 4526 39 the the DT cord-010092-uftc8inx 4526 40 biggest big JJS cord-010092-uftc8inx 4526 41 blood blood NN cord-010092-uftc8inx 4526 42 bank bank NN cord-010092-uftc8inx 4526 43 of of IN cord-010092-uftc8inx 4526 44 the the DT cord-010092-uftc8inx 4526 45 country country NN cord-010092-uftc8inx 4526 46 with with IN cord-010092-uftc8inx 4526 47 annual annual JJ cord-010092-uftc8inx 4526 48 collection collection NN cord-010092-uftc8inx 4526 49 of of IN cord-010092-uftc8inx 4526 50 70,000 70,000 CD cord-010092-uftc8inx 4526 51 blood blood NN cord-010092-uftc8inx 4526 52 units unit NNS cord-010092-uftc8inx 4526 53 . . . cord-010092-uftc8inx 4527 1 2000 2000 CD cord-010092-uftc8inx 4527 2 patients patient NNS cord-010092-uftc8inx 4527 3 of of IN cord-010092-uftc8inx 4527 4 thalassemia thalassemia NN cord-010092-uftc8inx 4527 5 , , , cord-010092-uftc8inx 4527 6 aplastic aplastic JJ cord-010092-uftc8inx 4527 7 anemia anemia NN cord-010092-uftc8inx 4527 8 and and CC cord-010092-uftc8inx 4527 9 leukemia leukemia NN cord-010092-uftc8inx 4527 10 were be VBD cord-010092-uftc8inx 4527 11 taken take VBN cord-010092-uftc8inx 4527 12 who who WP cord-010092-uftc8inx 4527 13 required require VBD cord-010092-uftc8inx 4527 14 multiple multiple JJ cord-010092-uftc8inx 4527 15 transfusions transfusion NNS cord-010092-uftc8inx 4527 16 . . . cord-010092-uftc8inx 4528 1 Complete complete JJ cord-010092-uftc8inx 4528 2 Phenotyping phenotyping NN cord-010092-uftc8inx 4528 3 was be VBD cord-010092-uftc8inx 4528 4 done do VBN cord-010092-uftc8inx 4528 5 initially initially RB cord-010092-uftc8inx 4528 6 of of IN cord-010092-uftc8inx 4528 7 all all PDT cord-010092-uftc8inx 4528 8 the the DT cord-010092-uftc8inx 4528 9 patients patient NNS cord-010092-uftc8inx 4528 10 before before IN cord-010092-uftc8inx 4528 11 transfusion transfusion NN cord-010092-uftc8inx 4528 12 . . . cord-010092-uftc8inx 4529 1 1000 1000 CD cord-010092-uftc8inx 4529 2 patients patient NNS cord-010092-uftc8inx 4529 3 were be VBD cord-010092-uftc8inx 4529 4 taken take VBN cord-010092-uftc8inx 4529 5 as as IN cord-010092-uftc8inx 4529 6 control control NN cord-010092-uftc8inx 4529 7 and and CC cord-010092-uftc8inx 4529 8 the the DT cord-010092-uftc8inx 4529 9 other other JJ cord-010092-uftc8inx 4529 10 1000 1000 CD cord-010092-uftc8inx 4529 11 were be VBD cord-010092-uftc8inx 4529 12 taken take VBN cord-010092-uftc8inx 4529 13 as as IN cord-010092-uftc8inx 4529 14 cases case NNS cord-010092-uftc8inx 4529 15 . . . cord-010092-uftc8inx 4530 1 2482 2482 CD cord-010092-uftc8inx 4530 2 Blood blood NN cord-010092-uftc8inx 4530 3 units unit NNS cord-010092-uftc8inx 4530 4 of of IN cord-010092-uftc8inx 4530 5 healthy healthy JJ cord-010092-uftc8inx 4530 6 donors donor NNS cord-010092-uftc8inx 4530 7 were be VBD cord-010092-uftc8inx 4530 8 chosen choose VBN cord-010092-uftc8inx 4530 9 ( ( -LRB- cord-010092-uftc8inx 4530 10 2442 2442 CD cord-010092-uftc8inx 4530 11 were be VBD cord-010092-uftc8inx 4530 12 males male NNS cord-010092-uftc8inx 4530 13 and and CC cord-010092-uftc8inx 4530 14 40 40 CD cord-010092-uftc8inx 4530 15 were be VBD cord-010092-uftc8inx 4530 16 females female NNS cord-010092-uftc8inx 4530 17 ) ) -RRB- cord-010092-uftc8inx 4530 18 . . . cord-010092-uftc8inx 4531 1 In in IN cord-010092-uftc8inx 4531 2 all all PDT cord-010092-uftc8inx 4531 3 the the DT cord-010092-uftc8inx 4531 4 donor donor NN cord-010092-uftc8inx 4531 5 units unit NNS cord-010092-uftc8inx 4531 6 , , , cord-010092-uftc8inx 4531 7 identification identification NN cord-010092-uftc8inx 4531 8 of of IN cord-010092-uftc8inx 4531 9 Rh Rh NNP cord-010092-uftc8inx 4531 10 & & CC cord-010092-uftc8inx 4531 11 Kell Kell NNP cord-010092-uftc8inx 4531 12 Phenotyping Phenotyping NNP cord-010092-uftc8inx 4531 13 was be VBD cord-010092-uftc8inx 4531 14 done do VBN cord-010092-uftc8inx 4531 15 by by IN cord-010092-uftc8inx 4531 16 the the DT cord-010092-uftc8inx 4531 17 antigen antigen NN cord-010092-uftc8inx 4531 18 antibody antibody NN cord-010092-uftc8inx 4531 19 agglutination agglutination NN cord-010092-uftc8inx 4531 20 test test NN cord-010092-uftc8inx 4531 21 by by IN cord-010092-uftc8inx 4531 22 the the DT cord-010092-uftc8inx 4531 23 Erythrocyte Erythrocyte NNP cord-010092-uftc8inx 4531 24 Magnetize Magnetize NNP cord-010092-uftc8inx 4531 25 Technology Technology NNP cord-010092-uftc8inx 4531 26 on on IN cord-010092-uftc8inx 4531 27 fully fully RB cord-010092-uftc8inx 4531 28 automated automate VBN cord-010092-uftc8inx 4531 29 Immunohaematology immunohaematology NN cord-010092-uftc8inx 4531 30 analyzer analyzer NN cord-010092-uftc8inx 4531 31 Qwalys Qwalys NNP cord-010092-uftc8inx 4531 32 . . . cord-010092-uftc8inx 4532 1 These these DT cord-010092-uftc8inx 4532 2 blood blood NN cord-010092-uftc8inx 4532 3 units unit NNS cord-010092-uftc8inx 4532 4 were be VBD cord-010092-uftc8inx 4532 5 transfused transfuse VBN cord-010092-uftc8inx 4532 6 to to IN cord-010092-uftc8inx 4532 7 1000 1000 CD cord-010092-uftc8inx 4532 8 patients patient NNS cord-010092-uftc8inx 4532 9 who who WP cord-010092-uftc8inx 4532 10 had have VBD cord-010092-uftc8inx 4532 11 been be VBN cord-010092-uftc8inx 4532 12 selected select VBN cord-010092-uftc8inx 4532 13 as as IN cord-010092-uftc8inx 4532 14 cases case NNS cord-010092-uftc8inx 4532 15 . . . cord-010092-uftc8inx 4533 1 In in IN cord-010092-uftc8inx 4533 2 the the DT cord-010092-uftc8inx 4533 3 control control NN cord-010092-uftc8inx 4533 4 group group NN cord-010092-uftc8inx 4533 5 , , , cord-010092-uftc8inx 4533 6 patients patient NNS cord-010092-uftc8inx 4533 7 were be VBD cord-010092-uftc8inx 4533 8 transfused transfuse VBN cord-010092-uftc8inx 4533 9 blood blood NN cord-010092-uftc8inx 4533 10 units unit NNS cord-010092-uftc8inx 4533 11 which which WDT cord-010092-uftc8inx 4533 12 were be VBD cord-010092-uftc8inx 4533 13 not not RB cord-010092-uftc8inx 4533 14 phenotyped phenotype VBN cord-010092-uftc8inx 4533 15 for for IN cord-010092-uftc8inx 4533 16 Rh Rh NNP cord-010092-uftc8inx 4533 17 & & CC cord-010092-uftc8inx 4533 18 Kell Kell NNP cord-010092-uftc8inx 4533 19 but but CC cord-010092-uftc8inx 4533 20 gel gel NNP cord-010092-uftc8inx 4533 21 crossmatching crossmatching NN cord-010092-uftc8inx 4533 22 was be VBD cord-010092-uftc8inx 4533 23 done do VBN cord-010092-uftc8inx 4533 24 . . . cord-010092-uftc8inx 4534 1 Follow follow VB cord-010092-uftc8inx 4534 2 - - HYPH cord-010092-uftc8inx 4534 3 up up NN cord-010092-uftc8inx 4534 4 was be VBD cord-010092-uftc8inx 4534 5 done do VBN cord-010092-uftc8inx 4534 6 on on IN cord-010092-uftc8inx 4534 7 these these DT cord-010092-uftc8inx 4534 8 patients patient NNS cord-010092-uftc8inx 4534 9 for for IN cord-010092-uftc8inx 4534 10 transfusion transfusion NN cord-010092-uftc8inx 4534 11 reactions reaction NNS cord-010092-uftc8inx 4534 12 and and CC cord-010092-uftc8inx 4534 13 at at IN cord-010092-uftc8inx 4534 14 the the DT cord-010092-uftc8inx 4534 15 end end NN cord-010092-uftc8inx 4534 16 of of IN cord-010092-uftc8inx 4534 17 six six CD cord-010092-uftc8inx 4534 18 months month NNS cord-010092-uftc8inx 4534 19 they -PRON- PRP cord-010092-uftc8inx 4534 20 were be VBD cord-010092-uftc8inx 4534 21 evaluated evaluate VBN cord-010092-uftc8inx 4534 22 for for IN cord-010092-uftc8inx 4534 23 any any DT cord-010092-uftc8inx 4534 24 alloimmunisation alloimmunisation NN cord-010092-uftc8inx 4534 25 . . . cord-010092-uftc8inx 4535 1 Results result NNS cord-010092-uftc8inx 4535 2 : : : cord-010092-uftc8inx 4536 1 At at IN cord-010092-uftc8inx 4536 2 the the DT cord-010092-uftc8inx 4536 3 end end NN cord-010092-uftc8inx 4536 4 of of IN cord-010092-uftc8inx 4536 5 6 6 CD cord-010092-uftc8inx 4536 6 months month NNS cord-010092-uftc8inx 4536 7 , , , cord-010092-uftc8inx 4536 8 no no DT cord-010092-uftc8inx 4536 9 reactions reaction NNS cord-010092-uftc8inx 4536 10 were be VBD cord-010092-uftc8inx 4536 11 reported report VBN cord-010092-uftc8inx 4536 12 in in IN cord-010092-uftc8inx 4536 13 cases case NNS cord-010092-uftc8inx 4536 14 receiving receive VBG cord-010092-uftc8inx 4536 15 Rh Rh NNP cord-010092-uftc8inx 4536 16 & & CC cord-010092-uftc8inx 4536 17 Kell Kell NNP cord-010092-uftc8inx 4536 18 phenotype phenotype NN cord-010092-uftc8inx 4536 19 blood blood NN cord-010092-uftc8inx 4536 20 and and CC cord-010092-uftc8inx 4536 21 no no DT cord-010092-uftc8inx 4536 22 alloimmunisation alloimmunisation NN cord-010092-uftc8inx 4536 23 was be VBD cord-010092-uftc8inx 4536 24 seen see VBN cord-010092-uftc8inx 4536 25 on on IN cord-010092-uftc8inx 4536 26 repeat repeat NN cord-010092-uftc8inx 4536 27 phenotyping phenotyping NN cord-010092-uftc8inx 4536 28 . . . cord-010092-uftc8inx 4537 1 The the DT cord-010092-uftc8inx 4537 2 control control NN cord-010092-uftc8inx 4537 3 group group NN cord-010092-uftc8inx 4537 4 on on IN cord-010092-uftc8inx 4537 5 the the DT cord-010092-uftc8inx 4537 6 other other JJ cord-010092-uftc8inx 4537 7 hand hand NN cord-010092-uftc8inx 4537 8 reported report VBD cord-010092-uftc8inx 4537 9 reactions reaction NNS cord-010092-uftc8inx 4537 10 in in IN cord-010092-uftc8inx 4537 11 5 5 CD cord-010092-uftc8inx 4537 12 cases case NNS cord-010092-uftc8inx 4537 13 ( ( -LRB- cord-010092-uftc8inx 4537 14 0.5 0.5 CD cord-010092-uftc8inx 4537 15 % % NN cord-010092-uftc8inx 4537 16 ) ) -RRB- cord-010092-uftc8inx 4537 17 and and CC cord-010092-uftc8inx 4537 18 phenotype phenotype NN cord-010092-uftc8inx 4537 19 at at IN cord-010092-uftc8inx 4537 20 the the DT cord-010092-uftc8inx 4537 21 end end NN cord-010092-uftc8inx 4537 22 of of IN cord-010092-uftc8inx 4537 23 three three CD cord-010092-uftc8inx 4537 24 months month NNS cord-010092-uftc8inx 4537 25 showed show VBD cord-010092-uftc8inx 4537 26 alloimmunisation alloimmunisation NN cord-010092-uftc8inx 4537 27 with with IN cord-010092-uftc8inx 4537 28 ' ' `` cord-010092-uftc8inx 4537 29 E e NN cord-010092-uftc8inx 4537 30 ' ' '' cord-010092-uftc8inx 4537 31 antibody antibody NN cord-010092-uftc8inx 4537 32 . . . cord-010092-uftc8inx 4538 1 The the DT cord-010092-uftc8inx 4538 2 phenotypic phenotypic JJ cord-010092-uftc8inx 4538 3 frequencies frequency NNS cord-010092-uftc8inx 4538 4 of of IN cord-010092-uftc8inx 4538 5 Rh Rh NNP cord-010092-uftc8inx 4538 6 & & CC cord-010092-uftc8inx 4538 7 Kell Kell NNP cord-010092-uftc8inx 4538 8 blood blood NN cord-010092-uftc8inx 4538 9 groups group NNS cord-010092-uftc8inx 4538 10 in in IN cord-010092-uftc8inx 4538 11 the the DT cord-010092-uftc8inx 4538 12 population population NN cord-010092-uftc8inx 4538 13 were be VBD cord-010092-uftc8inx 4538 14 comparable comparable JJ cord-010092-uftc8inx 4538 15 with with IN cord-010092-uftc8inx 4538 16 other other JJ cord-010092-uftc8inx 4538 17 published publish VBN cord-010092-uftc8inx 4538 18 studies study NNS cord-010092-uftc8inx 4538 19 . . . cord-010092-uftc8inx 4539 1 Amongst amongst IN cord-010092-uftc8inx 4539 2 the the DT cord-010092-uftc8inx 4539 3 Rh Rh NNP cord-010092-uftc8inx 4539 4 antigens antigen NNS cord-010092-uftc8inx 4539 5 ( ( -LRB- cord-010092-uftc8inx 4539 6 e e NN cord-010092-uftc8inx 4539 7 ) ) -RRB- cord-010092-uftc8inx 4539 8 was be VBD cord-010092-uftc8inx 4539 9 the the DT cord-010092-uftc8inx 4539 10 most most RBS cord-010092-uftc8inx 4539 11 common common JJ cord-010092-uftc8inx 4539 12 ( ( -LRB- cord-010092-uftc8inx 4539 13 99.44 99.44 CD cord-010092-uftc8inx 4539 14 % % NN cord-010092-uftc8inx 4539 15 ) ) -RRB- cord-010092-uftc8inx 4539 16 followed follow VBN cord-010092-uftc8inx 4539 17 by by IN cord-010092-uftc8inx 4539 18 D D NNP cord-010092-uftc8inx 4539 19 ( ( -LRB- cord-010092-uftc8inx 4539 20 95.45 95.45 CD cord-010092-uftc8inx 4539 21 % % NN cord-010092-uftc8inx 4539 22 ) ) -RRB- cord-010092-uftc8inx 4539 23 , , , cord-010092-uftc8inx 4539 24 C C NNP cord-010092-uftc8inx 4539 25 ( ( -LRB- cord-010092-uftc8inx 4539 26 89.65 89.65 CD cord-010092-uftc8inx 4539 27 % % NN cord-010092-uftc8inx 4539 28 ) ) -RRB- cord-010092-uftc8inx 4539 29 , , , cord-010092-uftc8inx 4539 30 c c NN cord-010092-uftc8inx 4539 31 ( ( -LRB- cord-010092-uftc8inx 4539 32 53.1 53.1 CD cord-010092-uftc8inx 4539 33 % % NN cord-010092-uftc8inx 4539 34 ) ) -RRB- cord-010092-uftc8inx 4539 35 and and CC cord-010092-uftc8inx 4539 36 E e NN cord-010092-uftc8inx 4539 37 ( ( -LRB- cord-010092-uftc8inx 4539 38 17.65 17.65 CD cord-010092-uftc8inx 4539 39 % % NN cord-010092-uftc8inx 4539 40 ) ) -RRB- cord-010092-uftc8inx 4539 41 . . . cord-010092-uftc8inx 4540 1 Thus thus RB cord-010092-uftc8inx 4540 2 ' ' `` cord-010092-uftc8inx 4540 3 e e XX cord-010092-uftc8inx 4540 4 ' ' '' cord-010092-uftc8inx 4540 5 was be VBD cord-010092-uftc8inx 4540 6 the the DT cord-010092-uftc8inx 4540 7 most most RBS cord-010092-uftc8inx 4540 8 common common JJ cord-010092-uftc8inx 4540 9 and and CC cord-010092-uftc8inx 4540 10 E E NNP cord-010092-uftc8inx 4540 11 was be VBD cord-010092-uftc8inx 4540 12 the the DT cord-010092-uftc8inx 4540 13 least least JJS cord-010092-uftc8inx 4540 14 common common JJ cord-010092-uftc8inx 4540 15 of of IN cord-010092-uftc8inx 4540 16 all all PDT cord-010092-uftc8inx 4540 17 the the DT cord-010092-uftc8inx 4540 18 Rh Rh NNP cord-010092-uftc8inx 4540 19 types type NNS cord-010092-uftc8inx 4540 20 . . . cord-010092-uftc8inx 4541 1 Background background NN cord-010092-uftc8inx 4541 2 : : : cord-010092-uftc8inx 4542 1 The the DT cord-010092-uftc8inx 4542 2 prevalence prevalence NN cord-010092-uftc8inx 4542 3 of of IN cord-010092-uftc8inx 4542 4 a a DT cord-010092-uftc8inx 4542 5 particular particular JJ cord-010092-uftc8inx 4542 6 blood blood NN cord-010092-uftc8inx 4542 7 group group NN cord-010092-uftc8inx 4542 8 has have VBZ cord-010092-uftc8inx 4542 9 an an DT cord-010092-uftc8inx 4542 10 uneven uneven JJ cord-010092-uftc8inx 4542 11 distribution distribution NN cord-010092-uftc8inx 4542 12 in in IN cord-010092-uftc8inx 4542 13 different different JJ cord-010092-uftc8inx 4542 14 geographic geographic JJ cord-010092-uftc8inx 4542 15 areas area NNS cord-010092-uftc8inx 4542 16 and and CC cord-010092-uftc8inx 4542 17 is be VBZ cord-010092-uftc8inx 4542 18 largely largely RB cord-010092-uftc8inx 4542 19 determined determine VBN cord-010092-uftc8inx 4542 20 by by IN cord-010092-uftc8inx 4542 21 the the DT cord-010092-uftc8inx 4542 22 national national JJ cord-010092-uftc8inx 4542 23 composition composition NN cord-010092-uftc8inx 4542 24 of of IN cord-010092-uftc8inx 4542 25 the the DT cord-010092-uftc8inx 4542 26 population population NN cord-010092-uftc8inx 4542 27 . . . cord-010092-uftc8inx 4543 1 Moscow Moscow NNP cord-010092-uftc8inx 4543 2 is be VBZ cord-010092-uftc8inx 4543 3 one one CD cord-010092-uftc8inx 4543 4 of of IN cord-010092-uftc8inx 4543 5 the the DT cord-010092-uftc8inx 4543 6 largest large JJS cord-010092-uftc8inx 4543 7 city city NN cord-010092-uftc8inx 4543 8 of of IN cord-010092-uftc8inx 4543 9 Europe Europe NNP cord-010092-uftc8inx 4543 10 with with IN cord-010092-uftc8inx 4543 11 population population NN cord-010092-uftc8inx 4543 12 of of IN cord-010092-uftc8inx 4543 13 12.5 12.5 CD cord-010092-uftc8inx 4543 14 million million CD cord-010092-uftc8inx 4543 15 . . . cord-010092-uftc8inx 4544 1 The the DT cord-010092-uftc8inx 4544 2 understanding understanding NN cord-010092-uftc8inx 4544 3 of of IN cord-010092-uftc8inx 4544 4 prevalence prevalence NN cord-010092-uftc8inx 4544 5 of of IN cord-010092-uftc8inx 4544 6 red red JJ cord-010092-uftc8inx 4544 7 blood blood NN cord-010092-uftc8inx 4544 8 cells cell NNS cord-010092-uftc8inx 4544 9 antigens antigen NNS cord-010092-uftc8inx 4544 10 ( ( -LRB- cord-010092-uftc8inx 4544 11 RBC RBC NNP cord-010092-uftc8inx 4544 12 - - HYPH cord-010092-uftc8inx 4544 13 Ag Ag NNP cord-010092-uftc8inx 4544 14 ) ) -RRB- cord-010092-uftc8inx 4544 15 among among IN cord-010092-uftc8inx 4544 16 the the DT cord-010092-uftc8inx 4544 17 population population NN cord-010092-uftc8inx 4544 18 has have VBZ cord-010092-uftc8inx 4544 19 great great JJ cord-010092-uftc8inx 4544 20 importance importance NN cord-010092-uftc8inx 4544 21 for for IN cord-010092-uftc8inx 4544 22 blood blood NN cord-010092-uftc8inx 4544 23 banking banking NN cord-010092-uftc8inx 4544 24 planning planning NN cord-010092-uftc8inx 4544 25 . . . cord-010092-uftc8inx 4545 1 Aims aim VBZ cord-010092-uftc8inx 4545 2 : : : cord-010092-uftc8inx 4546 1 To to TO cord-010092-uftc8inx 4546 2 determine determine VB cord-010092-uftc8inx 4546 3 frequency frequency NN cord-010092-uftc8inx 4546 4 and and CC cord-010092-uftc8inx 4546 5 distribution distribution NN cord-010092-uftc8inx 4546 6 patterns pattern NNS cord-010092-uftc8inx 4546 7 of of IN cord-010092-uftc8inx 4546 8 transfusion transfusion NN cord-010092-uftc8inx 4546 9 - - HYPH cord-010092-uftc8inx 4546 10 significant significant JJ cord-010092-uftc8inx 4546 11 RBC RBC NNP cord-010092-uftc8inx 4546 12 - - HYPH cord-010092-uftc8inx 4546 13 Ag Ag NNP cord-010092-uftc8inx 4546 14 among among IN cord-010092-uftc8inx 4546 15 donors donor NNS cord-010092-uftc8inx 4546 16 in in IN cord-010092-uftc8inx 4546 17 the the DT cord-010092-uftc8inx 4546 18 Moscow Moscow NNP cord-010092-uftc8inx 4546 19 region region NN cord-010092-uftc8inx 4546 20 . . . cord-010092-uftc8inx 4547 1 Methods method NNS cord-010092-uftc8inx 4547 2 : : : cord-010092-uftc8inx 4548 1 The the DT cord-010092-uftc8inx 4548 2 results result NNS cord-010092-uftc8inx 4548 3 of of IN cord-010092-uftc8inx 4548 4 immunohematological immunohematological JJ cord-010092-uftc8inx 4548 5 studies study NNS cord-010092-uftc8inx 4548 6 on on IN cord-010092-uftc8inx 4548 7 AB0 AB0 NNP cord-010092-uftc8inx 4548 8 , , , cord-010092-uftc8inx 4548 9 Rhesus Rhesus NNP cord-010092-uftc8inx 4548 10 and and CC cord-010092-uftc8inx 4548 11 Kell Kell NNP cord-010092-uftc8inx 4548 12 systems system NNS cord-010092-uftc8inx 4548 13 were be VBD cord-010092-uftc8inx 4548 14 analyzed analyze VBN cord-010092-uftc8inx 4548 15 retrospectively retrospectively RB cord-010092-uftc8inx 4548 16 in in IN cord-010092-uftc8inx 4548 17 352362 352362 CD cord-010092-uftc8inx 4548 18 blood blood NN cord-010092-uftc8inx 4548 19 donors donor NNS cord-010092-uftc8inx 4548 20 for for IN cord-010092-uftc8inx 4548 21 14 14 CD cord-010092-uftc8inx 4548 22 years year NNS cord-010092-uftc8inx 4548 23 ( ( -LRB- cord-010092-uftc8inx 4548 24 2004 2004 CD cord-010092-uftc8inx 4548 25 ) ) -RRB- cord-010092-uftc8inx 4548 26 ( ( -LRB- cord-010092-uftc8inx 4548 27 2005 2005 CD cord-010092-uftc8inx 4548 28 ) ) -RRB- cord-010092-uftc8inx 4548 29 ( ( -LRB- cord-010092-uftc8inx 4548 30 2006 2006 CD cord-010092-uftc8inx 4548 31 ) ) -RRB- cord-010092-uftc8inx 4548 32 ( ( -LRB- cord-010092-uftc8inx 4548 33 2007 2007 CD cord-010092-uftc8inx 4548 34 ) ) -RRB- cord-010092-uftc8inx 4548 35 ( ( -LRB- cord-010092-uftc8inx 4548 36 2008 2008 CD cord-010092-uftc8inx 4548 37 ) ) -RRB- cord-010092-uftc8inx 4548 38 ( ( -LRB- cord-010092-uftc8inx 4548 39 2009 2009 CD cord-010092-uftc8inx 4548 40 ) ) -RRB- cord-010092-uftc8inx 4548 41 ( ( -LRB- cord-010092-uftc8inx 4548 42 2010 2010 CD cord-010092-uftc8inx 4548 43 ) ) -RRB- cord-010092-uftc8inx 4548 44 ( ( -LRB- cord-010092-uftc8inx 4548 45 2011 2011 CD cord-010092-uftc8inx 4548 46 ) ) -RRB- cord-010092-uftc8inx 4548 47 ( ( -LRB- cord-010092-uftc8inx 4548 48 2012 2012 CD cord-010092-uftc8inx 4548 49 ) ) -RRB- cord-010092-uftc8inx 4548 50 ( ( -LRB- cord-010092-uftc8inx 4548 51 2013 2013 CD cord-010092-uftc8inx 4548 52 ) ) -RRB- cord-010092-uftc8inx 4549 1 ( ( -LRB- cord-010092-uftc8inx 4549 2 2014 2014 CD cord-010092-uftc8inx 4549 3 ) ) -RRB- cord-010092-uftc8inx 4549 4 ( ( -LRB- cord-010092-uftc8inx 4549 5 2015 2015 CD cord-010092-uftc8inx 4549 6 ) ) -RRB- cord-010092-uftc8inx 4549 7 ( ( -LRB- cord-010092-uftc8inx 4549 8 2016 2016 CD cord-010092-uftc8inx 4549 9 ) ) -RRB- cord-010092-uftc8inx 4549 10 ( ( -LRB- cord-010092-uftc8inx 4549 11 2017 2017 CD cord-010092-uftc8inx 4549 12 ) ) -RRB- cord-010092-uftc8inx 4549 13 ( ( -LRB- cord-010092-uftc8inx 4549 14 2018 2018 CD cord-010092-uftc8inx 4549 15 ) ) -RRB- cord-010092-uftc8inx 4549 16 in in IN cord-010092-uftc8inx 4549 17 Moscow Moscow NNP cord-010092-uftc8inx 4549 18 . . . cord-010092-uftc8inx 4550 1 Data datum NNS cord-010092-uftc8inx 4550 2 collection collection NN cord-010092-uftc8inx 4550 3 and and CC cord-010092-uftc8inx 4550 4 processing processing NN cord-010092-uftc8inx 4550 5 was be VBD cord-010092-uftc8inx 4550 6 carried carry VBN cord-010092-uftc8inx 4550 7 out out RP cord-010092-uftc8inx 4550 8 using use VBG cord-010092-uftc8inx 4550 9 the the DT cord-010092-uftc8inx 4550 10 regional regional JJ cord-010092-uftc8inx 4550 11 information information NN cord-010092-uftc8inx 4550 12 system system NN cord-010092-uftc8inx 4550 13 for for IN cord-010092-uftc8inx 4550 14 transfusiology transfusiology NN cord-010092-uftc8inx 4550 15 . . . cord-010092-uftc8inx 4551 1 RBC RBC NNP cord-010092-uftc8inx 4551 2 - - HYPH cord-010092-uftc8inx 4551 3 Ag Ag NNP cord-010092-uftc8inx 4551 4 detection detection NN cord-010092-uftc8inx 4551 5 ( ( -LRB- cord-010092-uftc8inx 4551 6 AB0 AB0 NNP cord-010092-uftc8inx 4551 7 , , , cord-010092-uftc8inx 4551 8 Rh Rh NNP cord-010092-uftc8inx 4551 9 , , , cord-010092-uftc8inx 4551 10 Kell Kell NNP cord-010092-uftc8inx 4551 11 ) ) -RRB- cord-010092-uftc8inx 4551 12 systems system NNS cord-010092-uftc8inx 4551 13 was be VBD cord-010092-uftc8inx 4551 14 performed perform VBN cord-010092-uftc8inx 4551 15 using use VBG cord-010092-uftc8inx 4551 16 microplate microplate NN cord-010092-uftc8inx 4551 17 method method NN cord-010092-uftc8inx 4551 18 ( ( -LRB- cord-010092-uftc8inx 4551 19 automatic automatic JJ cord-010092-uftc8inx 4551 20 immunohematological immunohematological JJ cord-010092-uftc8inx 4551 21 analyzer analyzer NN cord-010092-uftc8inx 4551 22 " " `` cord-010092-uftc8inx 4551 23 Galileo Galileo NNP cord-010092-uftc8inx 4551 24 Neo Neo NNP cord-010092-uftc8inx 4551 25 " " '' cord-010092-uftc8inx 4551 26 ( ( -LRB- cord-010092-uftc8inx 4551 27 Immucor Immucor NNP cord-010092-uftc8inx 4551 28 , , , cord-010092-uftc8inx 4551 29 Inc. Inc. NNP cord-010092-uftc8inx 4551 30 , , , cord-010092-uftc8inx 4551 31 USA USA NNP cord-010092-uftc8inx 4551 32 ) ) -RRB- cord-010092-uftc8inx 4551 33 ) ) -RRB- cord-010092-uftc8inx 4551 34 and and CC cord-010092-uftc8inx 4551 35 " " `` cord-010092-uftc8inx 4551 36 IH-1000 ih-1000 NN cord-010092-uftc8inx 4551 37 " " '' cord-010092-uftc8inx 4551 38 ( ( -LRB- cord-010092-uftc8inx 4551 39 Bio Bio NNP cord-010092-uftc8inx 4551 40 - - HYPH cord-010092-uftc8inx 4551 41 Rad Rad NNP cord-010092-uftc8inx 4551 42 Laboratories Laboratories NNP cord-010092-uftc8inx 4551 43 , , , cord-010092-uftc8inx 4551 44 USA USA NNP cord-010092-uftc8inx 4551 45 ) ) -RRB- cord-010092-uftc8inx 4551 46 with with IN cord-010092-uftc8inx 4551 47 diagnostic diagnostic JJ cord-010092-uftc8inx 4551 48 cards card NNS cord-010092-uftc8inx 4551 49 . . . cord-010092-uftc8inx 4552 1 Results result NNS cord-010092-uftc8inx 4552 2 : : : cord-010092-uftc8inx 4553 1 The the DT cord-010092-uftc8inx 4553 2 most most RBS cord-010092-uftc8inx 4553 3 frequent frequent JJ cord-010092-uftc8inx 4553 4 blood blood NN cord-010092-uftc8inx 4553 5 group group NN cord-010092-uftc8inx 4553 6 is be VBZ cord-010092-uftc8inx 4553 7 A a DT cord-010092-uftc8inx 4553 8 ( ( -LRB- cord-010092-uftc8inx 4553 9 II II NNP cord-010092-uftc8inx 4553 10 ) ) -RRB- cord-010092-uftc8inx 4553 11 35.8 35.8 CD cord-010092-uftc8inx 4553 12 % % NN cord-010092-uftc8inx 4553 13 , , , cord-010092-uftc8inx 4553 14 0 0 NFP cord-010092-uftc8inx 4553 15 ( ( -LRB- cord-010092-uftc8inx 4553 16 I i NN cord-010092-uftc8inx 4553 17 ) ) -RRB- cord-010092-uftc8inx 4553 18 blood blood NN cord-010092-uftc8inx 4553 19 group group NN cord-010092-uftc8inx 4553 20 34.3 34.3 CD cord-010092-uftc8inx 4553 21 % % NN cord-010092-uftc8inx 4553 22 , , , cord-010092-uftc8inx 4553 23 B B NNP cord-010092-uftc8inx 4553 24 ( ( -LRB- cord-010092-uftc8inx 4553 25 III III NNP cord-010092-uftc8inx 4553 26 ) ) -RRB- cord-010092-uftc8inx 4553 27 21.3 21.3 CD cord-010092-uftc8inx 4553 28 % % NN cord-010092-uftc8inx 4553 29 , , , cord-010092-uftc8inx 4553 30 AB AB NNP cord-010092-uftc8inx 4553 31 ( ( -LRB- cord-010092-uftc8inx 4553 32 IV IV NNP cord-010092-uftc8inx 4553 33 ) ) -RRB- cord-010092-uftc8inx 4553 34 8.6 8.6 CD cord-010092-uftc8inx 4553 35 % % NN cord-010092-uftc8inx 4553 36 ( ( -LRB- cord-010092-uftc8inx 4553 37 n n NN cord-010092-uftc8inx 4553 38 = = SYM cord-010092-uftc8inx 4553 39 352362 352362 CD cord-010092-uftc8inx 4553 40 ) ) -RRB- cord-010092-uftc8inx 4553 41 . . . cord-010092-uftc8inx 4554 1 Rh(D+ Rh(D+ NNP cord-010092-uftc8inx 4554 2 ) ) -RRB- cord-010092-uftc8inx 4554 3 was be VBD cord-010092-uftc8inx 4554 4 established establish VBN cord-010092-uftc8inx 4554 5 as as IN cord-010092-uftc8inx 4554 6 positive positive JJ cord-010092-uftc8inx 4554 7 in in IN cord-010092-uftc8inx 4554 8 the the DT cord-010092-uftc8inx 4554 9 presence presence NN cord-010092-uftc8inx 4554 10 of of IN cord-010092-uftc8inx 4554 11 antigen antigen NNP cord-010092-uftc8inx 4554 12 D D NNP cord-010092-uftc8inx 4554 13 and and CC cord-010092-uftc8inx 4554 14 as as IN cord-010092-uftc8inx 4554 15 Rh(D- Rh(D- NNPS cord-010092-uftc8inx 4554 16 ) ) -RRB- cord-010092-uftc8inx 4554 17 negative negative JJ cord-010092-uftc8inx 4554 18 in in IN cord-010092-uftc8inx 4554 19 its -PRON- PRP$ cord-010092-uftc8inx 4554 20 absence absence NN cord-010092-uftc8inx 4554 21 . . . cord-010092-uftc8inx 4555 1 Donors donor NNS cord-010092-uftc8inx 4555 2 with with IN cord-010092-uftc8inx 4555 3 weak weak JJ cord-010092-uftc8inx 4555 4 variants variant NNS cord-010092-uftc8inx 4555 5 of of IN cord-010092-uftc8inx 4555 6 antigen antigen NN cord-010092-uftc8inx 4555 7 D D NNP cord-010092-uftc8inx 4555 8 ( ( -LRB- cord-010092-uftc8inx 4555 9 Du Du NNP cord-010092-uftc8inx 4555 10 ) ) -RRB- cord-010092-uftc8inx 4555 11 were be VBD cord-010092-uftc8inx 4555 12 determined determine VBN cord-010092-uftc8inx 4555 13 as as IN cord-010092-uftc8inx 4555 14 Rh Rh NNP cord-010092-uftc8inx 4555 15 ( ( -LRB- cord-010092-uftc8inx 4555 16 D+ D+ NNP cord-010092-uftc8inx 4555 17 ) ) -RRB- cord-010092-uftc8inx 4555 18 positive positive JJ cord-010092-uftc8inx 4555 19 . . . cord-010092-uftc8inx 4556 1 The the DT cord-010092-uftc8inx 4556 2 ratio ratio NN cord-010092-uftc8inx 4556 3 of of IN cord-010092-uftc8inx 4556 4 Rh Rh NNP cord-010092-uftc8inx 4556 5 ( ( -LRB- cord-010092-uftc8inx 4556 6 D+ D+ NNP cord-010092-uftc8inx 4556 7 ) ) -RRB- cord-010092-uftc8inx 4556 8 and and CC cord-010092-uftc8inx 4556 9 Rh Rh NNP cord-010092-uftc8inx 4556 10 ( ( -LRB- cord-010092-uftc8inx 4556 11 D- D- NNP cord-010092-uftc8inx 4556 12 ) ) -RRB- cord-010092-uftc8inx 4556 13 was be VBD cord-010092-uftc8inx 4556 14 82.8 82.8 CD cord-010092-uftc8inx 4556 15 % % NN cord-010092-uftc8inx 4556 16 and and CC cord-010092-uftc8inx 4556 17 17.2 17.2 CD cord-010092-uftc8inx 4556 18 % % NN cord-010092-uftc8inx 4556 19 , , , cord-010092-uftc8inx 4556 20 respectively respectively RB cord-010092-uftc8inx 4556 21 . . . cord-010092-uftc8inx 4557 1 Donor donor NN cord-010092-uftc8inx 4557 2 's 's POS cord-010092-uftc8inx 4557 3 phenotype phenotype NN cord-010092-uftc8inx 4557 4 detection detection NN cord-010092-uftc8inx 4557 5 was be VBD cord-010092-uftc8inx 4557 6 routinely routinely RB cord-010092-uftc8inx 4557 7 conducted conduct VBN cord-010092-uftc8inx 4557 8 from from IN cord-010092-uftc8inx 4557 9 the the DT cord-010092-uftc8inx 4557 10 2013 2013 CD cord-010092-uftc8inx 4557 11 year year NN cord-010092-uftc8inx 4557 12 , , , cord-010092-uftc8inx 4557 13 therefore therefore RB cord-010092-uftc8inx 4557 14 the the DT cord-010092-uftc8inx 4557 15 number number NN cord-010092-uftc8inx 4557 16 of of IN cord-010092-uftc8inx 4557 17 donors donor NNS cord-010092-uftc8inx 4557 18 was be VBD cord-010092-uftc8inx 4557 19 152883 152883 CD cord-010092-uftc8inx 4557 20 . . . cord-010092-uftc8inx 4558 1 The the DT cord-010092-uftc8inx 4558 2 most most RBS cord-010092-uftc8inx 4558 3 common common JJ cord-010092-uftc8inx 4558 4 phenotype phenotype NN cord-010092-uftc8inx 4558 5 among among IN cord-010092-uftc8inx 4558 6 donors donor NNS cord-010092-uftc8inx 4558 7 CcDee CcDee NNP cord-010092-uftc8inx 4558 8 ( ( -LRB- cord-010092-uftc8inx 4558 9 32.61 32.61 CD cord-010092-uftc8inx 4558 10 % % NN cord-010092-uftc8inx 4558 11 ) ) -RRB- cord-010092-uftc8inx 4558 12 , , , cord-010092-uftc8inx 4558 13 the the DT cord-010092-uftc8inx 4558 14 second second JJ cord-010092-uftc8inx 4558 15 in in IN cord-010092-uftc8inx 4558 16 frequency frequency NN cord-010092-uftc8inx 4558 17 CCDee CCDee NNP cord-010092-uftc8inx 4558 18 ( ( -LRB- cord-010092-uftc8inx 4558 19 19.33 19.33 CD cord-010092-uftc8inx 4558 20 % % NN cord-010092-uftc8inx 4558 21 ) ) -RRB- cord-010092-uftc8inx 4558 22 , , , cord-010092-uftc8inx 4558 23 the the DT cord-010092-uftc8inx 4558 24 third third JJ cord-010092-uftc8inx 4558 25 in in IN cord-010092-uftc8inx 4558 26 frequency frequency NN cord-010092-uftc8inx 4558 27 rhesus rhesu NNS cord-010092-uftc8inx 4558 28 negative negative JJ cord-010092-uftc8inx 4558 29 phenotype phenotype NN cord-010092-uftc8inx 4558 30 ccddee ccddee NNS cord-010092-uftc8inx 4558 31 ( ( -LRB- cord-010092-uftc8inx 4558 32 15.42 15.42 CD cord-010092-uftc8inx 4558 33 % % NN cord-010092-uftc8inx 4558 34 ) ) -RRB- cord-010092-uftc8inx 4558 35 in in IN cord-010092-uftc8inx 4558 36 the the DT cord-010092-uftc8inx 4558 37 studied study VBN cord-010092-uftc8inx 4558 38 population population NN cord-010092-uftc8inx 4558 39 . . . cord-010092-uftc8inx 4559 1 The the DT cord-010092-uftc8inx 4559 2 CcDEe ccdee NN cord-010092-uftc8inx 4559 3 and and CC cord-010092-uftc8inx 4559 4 ccDEe ccdee NN cord-010092-uftc8inx 4559 5 phenotypes phenotype NNS cord-010092-uftc8inx 4559 6 were be VBD cord-010092-uftc8inx 4559 7 14.04 14.04 CD cord-010092-uftc8inx 4559 8 % % NN cord-010092-uftc8inx 4559 9 and and CC cord-010092-uftc8inx 4559 10 12.17 12.17 CD cord-010092-uftc8inx 4559 11 % % NN cord-010092-uftc8inx 4559 12 , , , cord-010092-uftc8inx 4559 13 respectively respectively RB cord-010092-uftc8inx 4559 14 . . . cord-010092-uftc8inx 4560 1 The the DT cord-010092-uftc8inx 4560 2 most most RBS cord-010092-uftc8inx 4560 3 rare rare JJ cord-010092-uftc8inx 4560 4 are be VBP cord-010092-uftc8inx 4560 5 ccDEE ccdee JJ cord-010092-uftc8inx 4560 6 ( ( -LRB- cord-010092-uftc8inx 4560 7 2.65 2.65 CD cord-010092-uftc8inx 4560 8 % % NN cord-010092-uftc8inx 4560 9 ) ) -RRB- cord-010092-uftc8inx 4560 10 , , , cord-010092-uftc8inx 4560 11 ccDee ccDee NNP cord-010092-uftc8inx 4560 12 ( ( -LRB- cord-010092-uftc8inx 4560 13 1.86 1.86 CD cord-010092-uftc8inx 4560 14 % % NN cord-010092-uftc8inx 4560 15 ) ) -RRB- cord-010092-uftc8inx 4560 16 , , , cord-010092-uftc8inx 4560 17 Ccddee Ccddee NNP cord-010092-uftc8inx 4560 18 ( ( -LRB- cord-010092-uftc8inx 4560 19 1.54 1.54 CD cord-010092-uftc8inx 4560 20 % % NN cord-010092-uftc8inx 4560 21 ) ) -RRB- cord-010092-uftc8inx 4560 22 . . . cord-010092-uftc8inx 4561 1 Other other JJ cord-010092-uftc8inx 4561 2 options option NNS cord-010092-uftc8inx 4561 3 : : : cord-010092-uftc8inx 4561 4 ccddEe ccddee CD cord-010092-uftc8inx 4561 5 , , , cord-010092-uftc8inx 4561 6 CCDEe CCDEe NNS cord-010092-uftc8inx 4561 7 , , , cord-010092-uftc8inx 4561 8 CcDEE CcDEE NNP cord-010092-uftc8inx 4561 9 , , , cord-010092-uftc8inx 4561 10 CCddee CCddee NNP cord-010092-uftc8inx 4561 11 , , , cord-010092-uftc8inx 4561 12 CcddEe CcddEe NNP cord-010092-uftc8inx 4561 13 , , , cord-010092-uftc8inx 4561 14 CCDEE CCDEE NNP cord-010092-uftc8inx 4561 15 , , , cord-010092-uftc8inx 4562 1 CCddEe CCddEe NNP cord-010092-uftc8inx 4562 2 were be VBD cord-010092-uftc8inx 4562 3 detected detect VBN cord-010092-uftc8inx 4562 4 in in IN cord-010092-uftc8inx 4562 5 single single JJ cord-010092-uftc8inx 4562 6 cases case NNS cord-010092-uftc8inx 4562 7 and and CC cord-010092-uftc8inx 4562 8 amounted amount VBD cord-010092-uftc8inx 4562 9 to to IN cord-010092-uftc8inx 4562 10 a a DT cord-010092-uftc8inx 4562 11 total total NN cord-010092-uftc8inx 4562 12 of of IN cord-010092-uftc8inx 4562 13 0.37 0.37 CD cord-010092-uftc8inx 4562 14 % % NN cord-010092-uftc8inx 4562 15 ( ( -LRB- cord-010092-uftc8inx 4562 16 n n NN cord-010092-uftc8inx 4562 17 = = SYM cord-010092-uftc8inx 4562 18 152883 152883 CD cord-010092-uftc8inx 4562 19 ) ) -RRB- cord-010092-uftc8inx 4562 20 . . . cord-010092-uftc8inx 4563 1 Cw Cw NNP cord-010092-uftc8inx 4563 2 antigen antigen NNP cord-010092-uftc8inx 4563 3 was be VBD cord-010092-uftc8inx 4563 4 tested test VBN cord-010092-uftc8inx 4563 5 in in IN cord-010092-uftc8inx 4563 6 104230 104230 CD cord-010092-uftc8inx 4563 7 donors donor NNS cord-010092-uftc8inx 4563 8 and and CC cord-010092-uftc8inx 4563 9 was be VBD cord-010092-uftc8inx 4563 10 detected detect VBN cord-010092-uftc8inx 4563 11 in in IN cord-010092-uftc8inx 4563 12 5.28 5.28 CD cord-010092-uftc8inx 4563 13 % % NN cord-010092-uftc8inx 4563 14 . . . cord-010092-uftc8inx 4564 1 Cw Cw NNP cord-010092-uftc8inx 4564 2 is be VBZ cord-010092-uftc8inx 4564 3 most most RBS cord-010092-uftc8inx 4564 4 commonly commonly RB cord-010092-uftc8inx 4564 5 found find VBN cord-010092-uftc8inx 4564 6 in in IN cord-010092-uftc8inx 4564 7 donors donor NNS cord-010092-uftc8inx 4564 8 with with IN cord-010092-uftc8inx 4564 9 CCDDee ccddee JJ cord-010092-uftc8inx 4564 10 phenotypes phenotype NNS cord-010092-uftc8inx 4564 11 ( ( -LRB- cord-010092-uftc8inx 4564 12 2.36 2.36 CD cord-010092-uftc8inx 4564 13 % % NN cord-010092-uftc8inx 4564 14 ) ) -RRB- cord-010092-uftc8inx 4564 15 , , , cord-010092-uftc8inx 4564 16 CcDee CcDee NNP cord-010092-uftc8inx 4564 17 ( ( -LRB- cord-010092-uftc8inx 4564 18 2.03 2.03 CD cord-010092-uftc8inx 4564 19 % % NN cord-010092-uftc8inx 4564 20 ) ) -RRB- cord-010092-uftc8inx 4564 21 and and CC cord-010092-uftc8inx 4564 22 CcDEe CcDEe NNP cord-010092-uftc8inx 4564 23 ( ( -LRB- cord-010092-uftc8inx 4564 24 0.79 0.79 CD cord-010092-uftc8inx 4564 25 % % NN cord-010092-uftc8inx 4564 26 ) ) -RRB- cord-010092-uftc8inx 4564 27 , , , cord-010092-uftc8inx 4564 28 with with IN cord-010092-uftc8inx 4564 29 other other JJ cord-010092-uftc8inx 4564 30 variants variant NNS cord-010092-uftc8inx 4564 31 of of IN cord-010092-uftc8inx 4564 32 the the DT cord-010092-uftc8inx 4564 33 data data NN cord-010092-uftc8inx 4564 34 phenotype phenotype NN cord-010092-uftc8inx 4564 35 , , , cord-010092-uftc8inx 4564 36 the the DT cord-010092-uftc8inx 4564 37 antigen antigen NN cord-010092-uftc8inx 4564 38 was be VBD cord-010092-uftc8inx 4564 39 detected detect VBN cord-010092-uftc8inx 4564 40 in in IN cord-010092-uftc8inx 4564 41 0.1 0.1 CD cord-010092-uftc8inx 4564 42 % % NN cord-010092-uftc8inx 4564 43 of of IN cord-010092-uftc8inx 4564 44 the the DT cord-010092-uftc8inx 4564 45 examined examine VBN cord-010092-uftc8inx 4564 46 ( ( -LRB- cord-010092-uftc8inx 4564 47 n n NN cord-010092-uftc8inx 4564 48 = = SYM cord-010092-uftc8inx 4564 49 104230 104230 CD cord-010092-uftc8inx 4564 50 ) ) -RRB- cord-010092-uftc8inx 4564 51 . . . cord-010092-uftc8inx 4565 1 Antigen Antigen NNP cord-010092-uftc8inx 4565 2 K K NNP cord-010092-uftc8inx 4565 3 was be VBD cord-010092-uftc8inx 4565 4 detected detect VBN cord-010092-uftc8inx 4565 5 in in IN cord-010092-uftc8inx 4565 6 6.8 6.8 CD cord-010092-uftc8inx 4565 7 % % NN cord-010092-uftc8inx 4565 8 of of IN cord-010092-uftc8inx 4565 9 donors donor NNS cord-010092-uftc8inx 4565 10 , , , cord-010092-uftc8inx 4565 11 in in IN cord-010092-uftc8inx 4565 12 93.2 93.2 CD cord-010092-uftc8inx 4565 13 % % NN cord-010092-uftc8inx 4565 14 of of IN cord-010092-uftc8inx 4565 15 this this DT cord-010092-uftc8inx 4565 16 antigen antigen NN cord-010092-uftc8inx 4565 17 is be VBZ cord-010092-uftc8inx 4565 18 absent absent JJ cord-010092-uftc8inx 4565 19 ( ( -LRB- cord-010092-uftc8inx 4565 20 n n NN cord-010092-uftc8inx 4565 21 = = SYM cord-010092-uftc8inx 4565 22 352362 352362 CD cord-010092-uftc8inx 4565 23 ) ) -RRB- cord-010092-uftc8inx 4565 24 . . . cord-010092-uftc8inx 4566 1 Summary Summary NNP cord-010092-uftc8inx 4566 2 / / SYM cord-010092-uftc8inx 4566 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 4566 4 : : : cord-010092-uftc8inx 4567 1 The the DT cord-010092-uftc8inx 4567 2 study study NN cord-010092-uftc8inx 4567 3 of of IN cord-010092-uftc8inx 4567 4 transfusion transfusion NN cord-010092-uftc8inx 4567 5 - - HYPH cord-010092-uftc8inx 4567 6 relevant relevant JJ cord-010092-uftc8inx 4567 7 antigens antigen NNS cord-010092-uftc8inx 4567 8 distribution distribution NN cord-010092-uftc8inx 4567 9 in in IN cord-010092-uftc8inx 4567 10 population population NN cord-010092-uftc8inx 4567 11 is be VBZ cord-010092-uftc8inx 4567 12 necessary necessary JJ cord-010092-uftc8inx 4567 13 for for IN cord-010092-uftc8inx 4567 14 building building NN cord-010092-uftc8inx 4567 15 of of IN cord-010092-uftc8inx 4567 16 effective effective JJ cord-010092-uftc8inx 4567 17 and and CC cord-010092-uftc8inx 4567 18 flexible flexible JJ cord-010092-uftc8inx 4567 19 model model NN cord-010092-uftc8inx 4567 20 for for IN cord-010092-uftc8inx 4567 21 blood blood NN cord-010092-uftc8inx 4567 22 service service NN cord-010092-uftc8inx 4567 23 managing managing NN cord-010092-uftc8inx 4567 24 . . . cord-010092-uftc8inx 4568 1 A a DT cord-010092-uftc8inx 4568 2 differentiated differentiated JJ cord-010092-uftc8inx 4568 3 approach approach NN cord-010092-uftc8inx 4568 4 in in IN cord-010092-uftc8inx 4568 5 choosing choose VBG cord-010092-uftc8inx 4568 6 a a DT cord-010092-uftc8inx 4568 7 strategy strategy NN cord-010092-uftc8inx 4568 8 to to TO cord-010092-uftc8inx 4568 9 form form VB cord-010092-uftc8inx 4568 10 a a DT cord-010092-uftc8inx 4568 11 long long JJ cord-010092-uftc8inx 4568 12 - - HYPH cord-010092-uftc8inx 4568 13 term term NN cord-010092-uftc8inx 4568 14 bank bank NN cord-010092-uftc8inx 4568 15 for for IN cord-010092-uftc8inx 4568 16 storing store VBG cord-010092-uftc8inx 4568 17 blood blood NN cord-010092-uftc8inx 4568 18 components component NNS cord-010092-uftc8inx 4568 19 , , , cord-010092-uftc8inx 4568 20 taking take VBG cord-010092-uftc8inx 4568 21 into into IN cord-010092-uftc8inx 4568 22 account account NN cord-010092-uftc8inx 4568 23 the the DT cord-010092-uftc8inx 4568 24 frequency frequency NN cord-010092-uftc8inx 4568 25 of of IN cord-010092-uftc8inx 4568 26 various various JJ cord-010092-uftc8inx 4568 27 antigen antigen NN cord-010092-uftc8inx 4568 28 variants variant NNS cord-010092-uftc8inx 4568 29 , , , cord-010092-uftc8inx 4568 30 contributes contribute VBZ cord-010092-uftc8inx 4568 31 to to IN cord-010092-uftc8inx 4568 32 improving improve VBG cord-010092-uftc8inx 4568 33 the the DT cord-010092-uftc8inx 4568 34 quality quality NN cord-010092-uftc8inx 4568 35 , , , cord-010092-uftc8inx 4568 36 accessibility accessibility NN cord-010092-uftc8inx 4568 37 and and CC cord-010092-uftc8inx 4568 38 safety safety NN cord-010092-uftc8inx 4568 39 of of IN cord-010092-uftc8inx 4568 40 medical medical JJ cord-010092-uftc8inx 4568 41 care care NN cord-010092-uftc8inx 4568 42 . . . cord-010092-uftc8inx 4569 1 of of IN cord-010092-uftc8inx 4569 2 dislocated dislocate VBN cord-010092-uftc8inx 4569 3 division division NN cord-010092-uftc8inx 4569 4 of of IN cord-010092-uftc8inx 4569 5 our -PRON- PRP$ cord-010092-uftc8inx 4569 6 Blood blood NN cord-010092-uftc8inx 4569 7 establishment establishment NN cord-010092-uftc8inx 4569 8 in in IN cord-010092-uftc8inx 4569 9 Orthopaedic orthopaedic JJ cord-010092-uftc8inx 4569 10 hospital hospital NN cord-010092-uftc8inx 4569 11 Valdoltra Valdoltra NNP cord-010092-uftc8inx 4569 12 ( ( -LRB- cord-010092-uftc8inx 4569 13 OBV OBV NNP cord-010092-uftc8inx 4569 14 ) ) -RRB- cord-010092-uftc8inx 4569 15 in in IN cord-010092-uftc8inx 4569 16 2014 2014 CD cord-010092-uftc8inx 4569 17 the the DT cord-010092-uftc8inx 4569 18 number number NN cord-010092-uftc8inx 4569 19 of of IN cord-010092-uftc8inx 4569 20 outdated outdated JJ cord-010092-uftc8inx 4569 21 units unit NNS cord-010092-uftc8inx 4569 22 at at IN cord-010092-uftc8inx 4569 23 the the DT cord-010092-uftc8inx 4569 24 hospital hospital NN cord-010092-uftc8inx 4569 25 side side NN cord-010092-uftc8inx 4569 26 dropped drop VBD cord-010092-uftc8inx 4569 27 considerably considerably RB cord-010092-uftc8inx 4569 28 . . . cord-010092-uftc8inx 4570 1 Results result NNS cord-010092-uftc8inx 4570 2 : : : cord-010092-uftc8inx 4571 1 Since since IN cord-010092-uftc8inx 4571 2 2008 2008 CD cord-010092-uftc8inx 4571 3 when when WRB cord-010092-uftc8inx 4571 4 the the DT cord-010092-uftc8inx 4571 5 issued issue VBN cord-010092-uftc8inx 4571 6 number number NN cord-010092-uftc8inx 4571 7 of of IN cord-010092-uftc8inx 4571 8 red red JJ cord-010092-uftc8inx 4571 9 blood blood NN cord-010092-uftc8inx 4571 10 cell cell NN cord-010092-uftc8inx 4571 11 units unit NNS cord-010092-uftc8inx 4571 12 ( ( -LRB- cord-010092-uftc8inx 4571 13 RBC RBC NNP cord-010092-uftc8inx 4571 14 ) ) -RRB- cord-010092-uftc8inx 4571 15 was be VBD cord-010092-uftc8inx 4571 16 5170 5170 CD cord-010092-uftc8inx 4571 17 the the DT cord-010092-uftc8inx 4571 18 amount amount NN cord-010092-uftc8inx 4571 19 of of IN cord-010092-uftc8inx 4571 20 issued issue VBN cord-010092-uftc8inx 4571 21 units unit NNS cord-010092-uftc8inx 4571 22 rose rise VBD cord-010092-uftc8inx 4571 23 to to IN cord-010092-uftc8inx 4571 24 5678 5678 CD cord-010092-uftc8inx 4571 25 in in IN cord-010092-uftc8inx 4571 26 2011 2011 CD cord-010092-uftc8inx 4571 27 and and CC cord-010092-uftc8inx 4571 28 then then RB cord-010092-uftc8inx 4571 29 dropped drop VBD cord-010092-uftc8inx 4571 30 more more RBR cord-010092-uftc8inx 4571 31 or or CC cord-010092-uftc8inx 4571 32 less less RBR cord-010092-uftc8inx 4571 33 steadily steadily RB cord-010092-uftc8inx 4571 34 to to IN cord-010092-uftc8inx 4571 35 4850 4850 CD cord-010092-uftc8inx 4571 36 in in IN cord-010092-uftc8inx 4571 37 2018 2018 CD cord-010092-uftc8inx 4571 38 . . . cord-010092-uftc8inx 4572 1 In in IN cord-010092-uftc8inx 4572 2 this this DT cord-010092-uftc8inx 4572 3 period period NN cord-010092-uftc8inx 4572 4 the the DT cord-010092-uftc8inx 4572 5 hospitals hospital NNS cord-010092-uftc8inx 4572 6 ' ' POS cord-010092-uftc8inx 4572 7 programmes programme NNS cord-010092-uftc8inx 4572 8 rose rise VBD cord-010092-uftc8inx 4572 9 for for IN cord-010092-uftc8inx 4572 10 10 10 CD cord-010092-uftc8inx 4572 11 % % NN cord-010092-uftc8inx 4572 12 in in IN cord-010092-uftc8inx 4572 13 all all DT cord-010092-uftc8inx 4572 14 areas area NNS cord-010092-uftc8inx 4572 15 . . . cord-010092-uftc8inx 4573 1 Number number NN cord-010092-uftc8inx 4573 2 of of IN cord-010092-uftc8inx 4573 3 donated donate VBN cord-010092-uftc8inx 4573 4 units unit NNS cord-010092-uftc8inx 4573 5 declined decline VBD cord-010092-uftc8inx 4573 6 from from IN cord-010092-uftc8inx 4573 7 6330 6330 CD cord-010092-uftc8inx 4573 8 in in IN cord-010092-uftc8inx 4573 9 2011 2011 CD cord-010092-uftc8inx 4573 10 to to IN cord-010092-uftc8inx 4573 11 4820 4820 CD cord-010092-uftc8inx 4573 12 in in IN cord-010092-uftc8inx 4573 13 2018 2018 CD cord-010092-uftc8inx 4573 14 . . . cord-010092-uftc8inx 4574 1 After after IN cord-010092-uftc8inx 4574 2 reorganization reorganization NN cord-010092-uftc8inx 4574 3 in in IN cord-010092-uftc8inx 4574 4 2009 2009 CD cord-010092-uftc8inx 4574 5 the the DT cord-010092-uftc8inx 4574 6 number number NN cord-010092-uftc8inx 4574 7 of of IN cord-010092-uftc8inx 4574 8 outdated outdated JJ cord-010092-uftc8inx 4574 9 units unit NNS cord-010092-uftc8inx 4574 10 fell fall VBD cord-010092-uftc8inx 4574 11 from from IN cord-010092-uftc8inx 4574 12 3 3 CD cord-010092-uftc8inx 4574 13 % % NN cord-010092-uftc8inx 4574 14 of of IN cord-010092-uftc8inx 4574 15 stocked stock VBN cord-010092-uftc8inx 4574 16 units unit NNS cord-010092-uftc8inx 4574 17 to to IN cord-010092-uftc8inx 4574 18 1.5 1.5 CD cord-010092-uftc8inx 4574 19 % % NN cord-010092-uftc8inx 4574 20 . . . cord-010092-uftc8inx 4575 1 After after IN cord-010092-uftc8inx 4575 2 setting set VBG cord-010092-uftc8inx 4575 3 a a DT cord-010092-uftc8inx 4575 4 dislocated dislocate VBN cord-010092-uftc8inx 4575 5 unit unit NN cord-010092-uftc8inx 4575 6 of of IN cord-010092-uftc8inx 4575 7 CTDIZ CTDIZ NNP cord-010092-uftc8inx 4575 8 on on IN cord-010092-uftc8inx 4575 9 OBV OBV NNP cord-010092-uftc8inx 4575 10 location location NN cord-010092-uftc8inx 4575 11 the the DT cord-010092-uftc8inx 4575 12 number number NN cord-010092-uftc8inx 4575 13 of of IN cord-010092-uftc8inx 4575 14 discarded discard VBN cord-010092-uftc8inx 4575 15 RBC RBC NNP cord-010092-uftc8inx 4575 16 fell fall VBD cord-010092-uftc8inx 4575 17 from from IN cord-010092-uftc8inx 4575 18 397 397 CD cord-010092-uftc8inx 4575 19 to to IN cord-010092-uftc8inx 4575 20 41 41 CD cord-010092-uftc8inx 4575 21 in in IN cord-010092-uftc8inx 4575 22 2018 2018 CD cord-010092-uftc8inx 4575 23 . . . cord-010092-uftc8inx 4576 1 For for IN cord-010092-uftc8inx 4576 2 transfusion transfusion NN cord-010092-uftc8inx 4576 3 specialist specialist NN cord-010092-uftc8inx 4576 4 who who WP cord-010092-uftc8inx 4576 5 is be VBZ cord-010092-uftc8inx 4576 6 constantly constantly RB cord-010092-uftc8inx 4576 7 in in IN cord-010092-uftc8inx 4576 8 contact contact NN cord-010092-uftc8inx 4576 9 with with IN cord-010092-uftc8inx 4576 10 the the DT cord-010092-uftc8inx 4576 11 clinician clinician NN cord-010092-uftc8inx 4576 12 in in IN cord-010092-uftc8inx 4576 13 the the DT cord-010092-uftc8inx 4576 14 hospital hospital NN cord-010092-uftc8inx 4576 15 the the DT cord-010092-uftc8inx 4576 16 most most RBS cord-010092-uftc8inx 4576 17 important important JJ cord-010092-uftc8inx 4576 18 day day NN cord-010092-uftc8inx 4576 19 routine routine NN cord-010092-uftc8inx 4576 20 is be VBZ cord-010092-uftc8inx 4576 21 when when WRB cord-010092-uftc8inx 4576 22 the the DT cord-010092-uftc8inx 4576 23 stock stock NN cord-010092-uftc8inx 4576 24 availability availability NN cord-010092-uftc8inx 4576 25 is be VBZ cord-010092-uftc8inx 4576 26 displayed display VBN cord-010092-uftc8inx 4576 27 . . . cord-010092-uftc8inx 4577 1 It -PRON- PRP cord-010092-uftc8inx 4577 2 happens happen VBZ cord-010092-uftc8inx 4577 3 4 4 CD cord-010092-uftc8inx 4577 4 times time NNS cord-010092-uftc8inx 4577 5 a a DT cord-010092-uftc8inx 4577 6 day day NN cord-010092-uftc8inx 4577 7 ; ; : cord-010092-uftc8inx 4577 8 at at IN cord-010092-uftc8inx 4577 9 10 10 CD cord-010092-uftc8inx 4577 10 a.m. a.m. NN cord-010092-uftc8inx 4577 11 when when WRB cord-010092-uftc8inx 4577 12 the the DT cord-010092-uftc8inx 4577 13 previews preview NNS cord-010092-uftc8inx 4577 14 ' ' POS cord-010092-uftc8inx 4577 15 day day NN cord-010092-uftc8inx 4577 16 collection collection NN cord-010092-uftc8inx 4577 17 is be VBZ cord-010092-uftc8inx 4577 18 released release VBN cord-010092-uftc8inx 4577 19 and and CC cord-010092-uftc8inx 4577 20 another another DT cord-010092-uftc8inx 4577 21 three three CD cord-010092-uftc8inx 4577 22 times time NNS cord-010092-uftc8inx 4577 23 a a DT cord-010092-uftc8inx 4577 24 day day NN cord-010092-uftc8inx 4577 25 when when WRB cord-010092-uftc8inx 4577 26 the the DT cord-010092-uftc8inx 4577 27 updates update NNS cord-010092-uftc8inx 4577 28 occur occur VBP cord-010092-uftc8inx 4577 29 . . . cord-010092-uftc8inx 4578 1 The the DT cord-010092-uftc8inx 4578 2 central central JJ cord-010092-uftc8inx 4578 3 base base NN cord-010092-uftc8inx 4578 4 is be VBZ cord-010092-uftc8inx 4578 5 led lead VBN cord-010092-uftc8inx 4578 6 in in IN cord-010092-uftc8inx 4578 7 Ljubljana Ljubljana NNP cord-010092-uftc8inx 4578 8 ( ( -LRB- cord-010092-uftc8inx 4578 9 the the DT cord-010092-uftc8inx 4578 10 capital capital NN cord-010092-uftc8inx 4578 11 ) ) -RRB- cord-010092-uftc8inx 4578 12 and and CC cord-010092-uftc8inx 4578 13 all all DT cord-010092-uftc8inx 4578 14 centres centre NNS cord-010092-uftc8inx 4578 15 are be VBP cord-010092-uftc8inx 4578 16 able able JJ cord-010092-uftc8inx 4578 17 to to TO cord-010092-uftc8inx 4578 18 control control VB cord-010092-uftc8inx 4578 19 and and CC cord-010092-uftc8inx 4578 20 order order VB cord-010092-uftc8inx 4578 21 the the DT cord-010092-uftc8inx 4578 22 stock stock NN cord-010092-uftc8inx 4578 23 for for IN cord-010092-uftc8inx 4578 24 the the DT cord-010092-uftc8inx 4578 25 blood blood NN cord-010092-uftc8inx 4578 26 banking banking NN cord-010092-uftc8inx 4578 27 . . . cord-010092-uftc8inx 4579 1 Blood blood NN cord-010092-uftc8inx 4579 2 wastage wastage NN cord-010092-uftc8inx 4579 3 remained remain VBD cord-010092-uftc8inx 4579 4 low low JJ cord-010092-uftc8inx 4579 5 and and CC cord-010092-uftc8inx 4579 6 the the DT cord-010092-uftc8inx 4579 7 traceability traceability NN cord-010092-uftc8inx 4579 8 of of IN cord-010092-uftc8inx 4579 9 the the DT cord-010092-uftc8inx 4579 10 blood blood NN cord-010092-uftc8inx 4579 11 usage usage NN cord-010092-uftc8inx 4579 12 in in IN cord-010092-uftc8inx 4579 13 south south JJ cord-010092-uftc8inx 4579 14 - - HYPH cord-010092-uftc8inx 4579 15 western western JJ cord-010092-uftc8inx 4579 16 region region NN cord-010092-uftc8inx 4579 17 remains remain VBZ cord-010092-uftc8inx 4579 18 high high JJ cord-010092-uftc8inx 4579 19 ( ( -LRB- cord-010092-uftc8inx 4579 20 99 99 CD cord-010092-uftc8inx 4579 21 % % NN cord-010092-uftc8inx 4579 22 ) ) -RRB- cord-010092-uftc8inx 4579 23 . . . cord-010092-uftc8inx 4580 1 Though though IN cord-010092-uftc8inx 4580 2 it -PRON- PRP cord-010092-uftc8inx 4580 3 is be VBZ cord-010092-uftc8inx 4580 4 not not RB cord-010092-uftc8inx 4580 5 supported support VBN cord-010092-uftc8inx 4580 6 by by IN cord-010092-uftc8inx 4580 7 an an DT cord-010092-uftc8inx 4580 8 informational informational JJ cord-010092-uftc8inx 4580 9 system system NN cord-010092-uftc8inx 4580 10 the the DT cord-010092-uftc8inx 4580 11 traceability traceability NN cord-010092-uftc8inx 4580 12 form form NN cord-010092-uftc8inx 4580 13 the the DT cord-010092-uftc8inx 4580 14 blood blood NN cord-010092-uftc8inx 4580 15 bank bank NN cord-010092-uftc8inx 4580 16 to to IN cord-010092-uftc8inx 4580 17 the the DT cord-010092-uftc8inx 4580 18 patient patient NN cord-010092-uftc8inx 4580 19 is be VBZ cord-010092-uftc8inx 4580 20 done do VBN cord-010092-uftc8inx 4580 21 on on IN cord-010092-uftc8inx 4580 22 paper paper NN cord-010092-uftc8inx 4580 23 . . . cord-010092-uftc8inx 4581 1 This this DT cord-010092-uftc8inx 4581 2 issue issue NN cord-010092-uftc8inx 4581 3 demands demand VBZ cord-010092-uftc8inx 4581 4 a a DT cord-010092-uftc8inx 4581 5 big big JJ cord-010092-uftc8inx 4581 6 effort effort NN cord-010092-uftc8inx 4581 7 by by IN cord-010092-uftc8inx 4581 8 the the DT cord-010092-uftc8inx 4581 9 staff staff NN cord-010092-uftc8inx 4581 10 in in IN cord-010092-uftc8inx 4581 11 blood blood NN cord-010092-uftc8inx 4581 12 bank bank NN cord-010092-uftc8inx 4581 13 and and CC cord-010092-uftc8inx 4581 14 in in IN cord-010092-uftc8inx 4581 15 hospitals hospital NNS cord-010092-uftc8inx 4581 16 . . . cord-010092-uftc8inx 4582 1 Summary Summary NNP cord-010092-uftc8inx 4582 2 / / SYM cord-010092-uftc8inx 4582 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 4582 4 : : : cord-010092-uftc8inx 4583 1 Reorganization reorganization NN cord-010092-uftc8inx 4583 2 enabled enable VBD cord-010092-uftc8inx 4583 3 better well JJR cord-010092-uftc8inx 4583 4 stock stock NN cord-010092-uftc8inx 4583 5 utilization utilization NN cord-010092-uftc8inx 4583 6 and and CC cord-010092-uftc8inx 4583 7 traceability traceability NN cord-010092-uftc8inx 4583 8 of of IN cord-010092-uftc8inx 4583 9 issued issue VBN cord-010092-uftc8inx 4583 10 units unit NNS cord-010092-uftc8inx 4583 11 . . . cord-010092-uftc8inx 4584 1 Sometimes sometimes RB cord-010092-uftc8inx 4584 2 it -PRON- PRP cord-010092-uftc8inx 4584 3 is be VBZ cord-010092-uftc8inx 4584 4 impossible impossible JJ cord-010092-uftc8inx 4584 5 to to TO cord-010092-uftc8inx 4584 6 predict predict VB cord-010092-uftc8inx 4584 7 the the DT cord-010092-uftc8inx 4584 8 peak peak NN cord-010092-uftc8inx 4584 9 demand demand NN cord-010092-uftc8inx 4584 10 of of IN cord-010092-uftc8inx 4584 11 RBC RBC NNP cord-010092-uftc8inx 4584 12 especially especially RB cord-010092-uftc8inx 4584 13 during during IN cord-010092-uftc8inx 4584 14 the the DT cord-010092-uftc8inx 4584 15 summer summer NN cord-010092-uftc8inx 4584 16 season season NN cord-010092-uftc8inx 4584 17 when when WRB cord-010092-uftc8inx 4584 18 the the DT cord-010092-uftc8inx 4584 19 population population NN cord-010092-uftc8inx 4584 20 of of IN cord-010092-uftc8inx 4584 21 the the DT cord-010092-uftc8inx 4584 22 area area NN cord-010092-uftc8inx 4584 23 doubles double NNS cord-010092-uftc8inx 4584 24 and and CC cord-010092-uftc8inx 4584 25 car car NN cord-010092-uftc8inx 4584 26 accidents accident NNS cord-010092-uftc8inx 4584 27 as as RB cord-010092-uftc8inx 4584 28 well well RB cord-010092-uftc8inx 4584 29 . . . cord-010092-uftc8inx 4585 1 Transfusion transfusion NN cord-010092-uftc8inx 4585 2 specialist specialist NN cord-010092-uftc8inx 4585 3 's 's POS cord-010092-uftc8inx 4585 4 effort effort NN cord-010092-uftc8inx 4585 5 in in IN cord-010092-uftc8inx 4585 6 assuring assure VBG cord-010092-uftc8inx 4585 7 the the DT cord-010092-uftc8inx 4585 8 optimal optimal JJ cord-010092-uftc8inx 4585 9 blood blood NN cord-010092-uftc8inx 4585 10 stock stock NN cord-010092-uftc8inx 4585 11 represents represent VBZ cord-010092-uftc8inx 4585 12 the the DT cord-010092-uftc8inx 4585 13 crucial crucial JJ cord-010092-uftc8inx 4585 14 daily daily JJ cord-010092-uftc8inx 4585 15 routine routine NN cord-010092-uftc8inx 4585 16 . . . cord-010092-uftc8inx 4586 1 Blood Blood NNP cord-010092-uftc8inx 4586 2 Bank Bank NNP cord-010092-uftc8inx 4586 3 , , , cord-010092-uftc8inx 4586 4 Grande Grande NNP cord-010092-uftc8inx 4586 5 International International NNP cord-010092-uftc8inx 4586 6 Hospital Hospital NNP cord-010092-uftc8inx 4586 7 , , , cord-010092-uftc8inx 4586 8 Kathmandu Kathmandu NNP cord-010092-uftc8inx 4586 9 , , , cord-010092-uftc8inx 4586 10 Nepal Nepal NNP cord-010092-uftc8inx 4586 11 Background Background NNP cord-010092-uftc8inx 4586 12 : : : cord-010092-uftc8inx 4586 13 Voluntary voluntary JJ cord-010092-uftc8inx 4586 14 non non JJ cord-010092-uftc8inx 4586 15 - - JJ cord-010092-uftc8inx 4586 16 remunerated remunerated JJ cord-010092-uftc8inx 4586 17 blood blood NN cord-010092-uftc8inx 4586 18 donor donor NN cord-010092-uftc8inx 4586 19 consists consist VBZ cord-010092-uftc8inx 4586 20 of of IN cord-010092-uftc8inx 4586 21 78 78 CD cord-010092-uftc8inx 4586 22 % % NN cord-010092-uftc8inx 4586 23 blood blood NN cord-010092-uftc8inx 4586 24 donor donor NN cord-010092-uftc8inx 4586 25 's 's POS cord-010092-uftc8inx 4586 26 population population NN cord-010092-uftc8inx 4586 27 in in IN cord-010092-uftc8inx 4586 28 Nepal Nepal NNP cord-010092-uftc8inx 4586 29 . . . cord-010092-uftc8inx 4587 1 Therefore therefore RB cord-010092-uftc8inx 4587 2 demographic demographic JJ cord-010092-uftc8inx 4587 3 about about IN cord-010092-uftc8inx 4587 4 the the DT cord-010092-uftc8inx 4587 5 distribution distribution NN cord-010092-uftc8inx 4587 6 of of IN cord-010092-uftc8inx 4587 7 blood blood NN cord-010092-uftc8inx 4587 8 donors donor NNS cord-010092-uftc8inx 4587 9 according accord VBG cord-010092-uftc8inx 4587 10 to to IN cord-010092-uftc8inx 4587 11 the the DT cord-010092-uftc8inx 4587 12 age age NN cord-010092-uftc8inx 4587 13 group group NN cord-010092-uftc8inx 4587 14 is be VBZ cord-010092-uftc8inx 4587 15 important important JJ cord-010092-uftc8inx 4587 16 to to TO cord-010092-uftc8inx 4587 17 achieve achieve VB cord-010092-uftc8inx 4587 18 100 100 CD cord-010092-uftc8inx 4587 19 % % NN cord-010092-uftc8inx 4587 20 Voluntary voluntary JJ cord-010092-uftc8inx 4587 21 nonremunerated nonremunerate VBN cord-010092-uftc8inx 4587 22 blood blood NN cord-010092-uftc8inx 4587 23 donors donor NNS cord-010092-uftc8inx 4587 24 in in IN cord-010092-uftc8inx 4587 25 Nepal Nepal NNP cord-010092-uftc8inx 4587 26 . . . cord-010092-uftc8inx 4588 1 Aims aim VBZ cord-010092-uftc8inx 4588 2 : : : cord-010092-uftc8inx 4589 1 To to TO cord-010092-uftc8inx 4589 2 explore explore VB cord-010092-uftc8inx 4589 3 the the DT cord-010092-uftc8inx 4589 4 demographic demographic JJ cord-010092-uftc8inx 4589 5 distribution distribution NN cord-010092-uftc8inx 4589 6 of of IN cord-010092-uftc8inx 4589 7 the the DT cord-010092-uftc8inx 4589 8 blood blood NN cord-010092-uftc8inx 4589 9 donor donor NN cord-010092-uftc8inx 4589 10 in in IN cord-010092-uftc8inx 4589 11 different different JJ cord-010092-uftc8inx 4589 12 age age NN cord-010092-uftc8inx 4589 13 group group NN cord-010092-uftc8inx 4589 14 in in IN cord-010092-uftc8inx 4589 15 the the DT cord-010092-uftc8inx 4589 16 Kathmandu Kathmandu NNP cord-010092-uftc8inx 4589 17 Nepal Nepal NNP cord-010092-uftc8inx 4589 18 . . . cord-010092-uftc8inx 4590 1 Methods method NNS cord-010092-uftc8inx 4590 2 : : : cord-010092-uftc8inx 4590 3 This this DT cord-010092-uftc8inx 4590 4 is be VBZ cord-010092-uftc8inx 4590 5 retrospective retrospective JJ cord-010092-uftc8inx 4590 6 study study NN cord-010092-uftc8inx 4590 7 conducted conduct VBN cord-010092-uftc8inx 4590 8 at at IN cord-010092-uftc8inx 4590 9 Nepal Nepal NNP cord-010092-uftc8inx 4590 10 Red Red NNP cord-010092-uftc8inx 4590 11 Cross Cross NNP cord-010092-uftc8inx 4590 12 Society Society NNP cord-010092-uftc8inx 4590 13 Central Central NNP cord-010092-uftc8inx 4590 14 Blood Blood NNP cord-010092-uftc8inx 4590 15 Transfusion Transfusion NNP cord-010092-uftc8inx 4590 16 Service Service NNP cord-010092-uftc8inx 4590 17 . . . cord-010092-uftc8inx 4591 1 Data datum NNS cord-010092-uftc8inx 4591 2 from from IN cord-010092-uftc8inx 4591 3 January January NNP cord-010092-uftc8inx 4591 4 2013 2013 CD cord-010092-uftc8inx 4591 5 to to IN cord-010092-uftc8inx 4591 6 January January NNP cord-010092-uftc8inx 4591 7 2017 2017 CD cord-010092-uftc8inx 4591 8 were be VBD cord-010092-uftc8inx 4591 9 collected collect VBN cord-010092-uftc8inx 4591 10 from from IN cord-010092-uftc8inx 4591 11 donor donor NN cord-010092-uftc8inx 4591 12 management management NN cord-010092-uftc8inx 4591 13 software software NN cord-010092-uftc8inx 4591 14 . . . cord-010092-uftc8inx 4592 1 The the DT cord-010092-uftc8inx 4592 2 data data NN cord-010092-uftc8inx 4592 3 includes include VBZ cord-010092-uftc8inx 4592 4 socio socio JJ cord-010092-uftc8inx 4592 5 demographic demographic JJ cord-010092-uftc8inx 4592 6 data datum NNS cord-010092-uftc8inx 4592 7 . . . cord-010092-uftc8inx 4593 1 Data datum NNS cord-010092-uftc8inx 4593 2 has have VBZ cord-010092-uftc8inx 4593 3 been be VBN cord-010092-uftc8inx 4593 4 process process NN cord-010092-uftc8inx 4593 5 with with IN cord-010092-uftc8inx 4593 6 SPSS SPSS NNP cord-010092-uftc8inx 4593 7 version version NN cord-010092-uftc8inx 4593 8 -17 -17 : cord-010092-uftc8inx 4593 9 Results result NNS cord-010092-uftc8inx 4593 10 : : : cord-010092-uftc8inx 4593 11 During during IN cord-010092-uftc8inx 4593 12 4 4 CD cord-010092-uftc8inx 4593 13 years year NNS cord-010092-uftc8inx 4593 14 study study NN cord-010092-uftc8inx 4593 15 period period NN cord-010092-uftc8inx 4593 16 , , , cord-010092-uftc8inx 4593 17 total total NN cord-010092-uftc8inx 4593 18 of of IN cord-010092-uftc8inx 4593 19 276,290 276,290 CD cord-010092-uftc8inx 4593 20 Blood blood NN cord-010092-uftc8inx 4593 21 donation donation NN cord-010092-uftc8inx 4593 22 happened happen VBD cord-010092-uftc8inx 4593 23 from from IN cord-010092-uftc8inx 4593 24 both both CC cord-010092-uftc8inx 4593 25 mobile mobile JJ cord-010092-uftc8inx 4593 26 blood blood NN cord-010092-uftc8inx 4593 27 collection collection NN cord-010092-uftc8inx 4593 28 and and CC cord-010092-uftc8inx 4593 29 in in IN cord-010092-uftc8inx 4593 30 - - HYPH cord-010092-uftc8inx 4593 31 house house NN cord-010092-uftc8inx 4593 32 blood blood NN cord-010092-uftc8inx 4593 33 collection collection NN cord-010092-uftc8inx 4593 34 . . . cord-010092-uftc8inx 4594 1 Out out IN cord-010092-uftc8inx 4594 2 of of IN cord-010092-uftc8inx 4594 3 276,290 276,290 CD cord-010092-uftc8inx 4594 4 Collection Collection NNP cord-010092-uftc8inx 4594 5 , , , cord-010092-uftc8inx 4594 6 48351 48351 CD cord-010092-uftc8inx 4594 7 ( ( -LRB- cord-010092-uftc8inx 4594 8 17.5 17.5 CD cord-010092-uftc8inx 4594 9 % % NN cord-010092-uftc8inx 4594 10 ) ) -RRB- cord-010092-uftc8inx 4594 11 are be VBP cord-010092-uftc8inx 4594 12 from from IN cord-010092-uftc8inx 4594 13 18 18 CD cord-010092-uftc8inx 4594 14 - - SYM cord-010092-uftc8inx 4594 15 24 24 CD cord-010092-uftc8inx 4594 16 age age NN cord-010092-uftc8inx 4594 17 group group NN cord-010092-uftc8inx 4594 18 ; ; : cord-010092-uftc8inx 4594 19 106924 106924 CD cord-010092-uftc8inx 4594 20 ( ( -LRB- cord-010092-uftc8inx 4594 21 38.7 38.7 CD cord-010092-uftc8inx 4594 22 % % NN cord-010092-uftc8inx 4594 23 ) ) -RRB- cord-010092-uftc8inx 4594 24 are be VBP cord-010092-uftc8inx 4594 25 from from IN cord-010092-uftc8inx 4594 26 25 25 CD cord-010092-uftc8inx 4594 27 - - SYM cord-010092-uftc8inx 4594 28 31 31 CD cord-010092-uftc8inx 4594 29 age age NN cord-010092-uftc8inx 4594 30 group group NN cord-010092-uftc8inx 4594 31 53324 53324 CD cord-010092-uftc8inx 4594 32 ( ( -LRB- cord-010092-uftc8inx 4594 33 19.3 19.3 CD cord-010092-uftc8inx 4594 34 % % NN cord-010092-uftc8inx 4594 35 ) ) -RRB- cord-010092-uftc8inx 4594 36 are be VBP cord-010092-uftc8inx 4594 37 from from IN cord-010092-uftc8inx 4594 38 32 32 CD cord-010092-uftc8inx 4594 39 - - SYM cord-010092-uftc8inx 4594 40 38 38 CD cord-010092-uftc8inx 4594 41 age age NN cord-010092-uftc8inx 4594 42 group group NN cord-010092-uftc8inx 4594 43 ; ; : cord-010092-uftc8inx 4594 44 34536 34536 CD cord-010092-uftc8inx 4594 45 ( ( -LRB- cord-010092-uftc8inx 4594 46 12.5 12.5 CD cord-010092-uftc8inx 4594 47 % % NN cord-010092-uftc8inx 4594 48 ) ) -RRB- cord-010092-uftc8inx 4594 49 are be VBP cord-010092-uftc8inx 4594 50 from from IN cord-010092-uftc8inx 4594 51 group group NN cord-010092-uftc8inx 4594 52 39 39 CD cord-010092-uftc8inx 4594 53 - - SYM cord-010092-uftc8inx 4594 54 45 45 CD cord-010092-uftc8inx 4594 55 age age NN cord-010092-uftc8inx 4594 56 group group NN cord-010092-uftc8inx 4594 57 ; ; : cord-010092-uftc8inx 4595 1 23761 23761 CD cord-010092-uftc8inx 4595 2 ( ( -LRB- cord-010092-uftc8inx 4595 3 8.6 8.6 CD cord-010092-uftc8inx 4595 4 % % NN cord-010092-uftc8inx 4595 5 ) ) -RRB- cord-010092-uftc8inx 4595 6 are be VBP cord-010092-uftc8inx 4595 7 from from IN cord-010092-uftc8inx 4595 8 age age NN cord-010092-uftc8inx 4595 9 group group NN cord-010092-uftc8inx 4595 10 46 46 CD cord-010092-uftc8inx 4595 11 - - SYM cord-010092-uftc8inx 4595 12 52 52 CD cord-010092-uftc8inx 4595 13 and and CC cord-010092-uftc8inx 4595 14 9394 9394 CD cord-010092-uftc8inx 4595 15 ( ( -LRB- cord-010092-uftc8inx 4595 16 3.4 3.4 CD cord-010092-uftc8inx 4595 17 % % NN cord-010092-uftc8inx 4595 18 ) ) -RRB- cord-010092-uftc8inx 4595 19 from from IN cord-010092-uftc8inx 4595 20 age age NN cord-010092-uftc8inx 4595 21 group group NN cord-010092-uftc8inx 4595 22 above above IN cord-010092-uftc8inx 4595 23 53 53 CD cord-010092-uftc8inx 4595 24 respectively respectively RB cord-010092-uftc8inx 4595 25 . . . cord-010092-uftc8inx 4596 1 Summary Summary NNP cord-010092-uftc8inx 4596 2 / / SYM cord-010092-uftc8inx 4596 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 4596 4 : : : cord-010092-uftc8inx 4597 1 The the DT cord-010092-uftc8inx 4597 2 distribution distribution NN cord-010092-uftc8inx 4597 3 of of IN cord-010092-uftc8inx 4597 4 ABO ABO NNP cord-010092-uftc8inx 4597 5 blood blood NN cord-010092-uftc8inx 4597 6 group group NN cord-010092-uftc8inx 4597 7 varies vary VBZ cord-010092-uftc8inx 4597 8 regionally regionally RB cord-010092-uftc8inx 4597 9 and and CC cord-010092-uftc8inx 4597 10 from from IN cord-010092-uftc8inx 4597 11 one one CD cord-010092-uftc8inx 4597 12 population population NN cord-010092-uftc8inx 4597 13 to to IN cord-010092-uftc8inx 4597 14 another another DT cord-010092-uftc8inx 4597 15 . . . cord-010092-uftc8inx 4598 1 In in IN cord-010092-uftc8inx 4598 2 Kathmandu Kathmandu NNP cord-010092-uftc8inx 4598 3 , , , cord-010092-uftc8inx 4598 4 Nepal Nepal NNP cord-010092-uftc8inx 4598 5 18 18 CD cord-010092-uftc8inx 4598 6 - - SYM cord-010092-uftc8inx 4598 7 38 38 CD cord-010092-uftc8inx 4598 8 years year NNS cord-010092-uftc8inx 4598 9 age age NN cord-010092-uftc8inx 4598 10 group group NN cord-010092-uftc8inx 4598 11 is be VBZ cord-010092-uftc8inx 4598 12 the the DT cord-010092-uftc8inx 4598 13 most most RBS cord-010092-uftc8inx 4598 14 common common JJ cord-010092-uftc8inx 4598 15 age age NN cord-010092-uftc8inx 4598 16 group group NN cord-010092-uftc8inx 4598 17 encountered encounter VBD cord-010092-uftc8inx 4598 18 donating donate VBG cord-010092-uftc8inx 4598 19 blood blood NN cord-010092-uftc8inx 4598 20 . . . cord-010092-uftc8inx 4599 1 The the DT cord-010092-uftc8inx 4599 2 data datum NNS cord-010092-uftc8inx 4599 3 generated generate VBN cord-010092-uftc8inx 4599 4 in in IN cord-010092-uftc8inx 4599 5 the the DT cord-010092-uftc8inx 4599 6 present present JJ cord-010092-uftc8inx 4599 7 study study NN cord-010092-uftc8inx 4599 8 and and CC cord-010092-uftc8inx 4599 9 several several JJ cord-010092-uftc8inx 4599 10 other other JJ cord-010092-uftc8inx 4599 11 studies study NNS cord-010092-uftc8inx 4599 12 of of IN cord-010092-uftc8inx 4599 13 different different JJ cord-010092-uftc8inx 4599 14 geographical geographical JJ cord-010092-uftc8inx 4599 15 region region NN cord-010092-uftc8inx 4599 16 of of IN cord-010092-uftc8inx 4599 17 India India NNP cord-010092-uftc8inx 4599 18 will will MD cord-010092-uftc8inx 4599 19 be be VB cord-010092-uftc8inx 4599 20 useful useful JJ cord-010092-uftc8inx 4599 21 to to IN cord-010092-uftc8inx 4599 22 health health NN cord-010092-uftc8inx 4599 23 planners planner NNS cord-010092-uftc8inx 4599 24 and and CC cord-010092-uftc8inx 4599 25 future future JJ cord-010092-uftc8inx 4599 26 health health NN cord-010092-uftc8inx 4599 27 challenges challenge NNS cord-010092-uftc8inx 4599 28 in in IN cord-010092-uftc8inx 4599 29 the the DT cord-010092-uftc8inx 4599 30 region region NN cord-010092-uftc8inx 4599 31 . . . cord-010092-uftc8inx 4600 1 Background background NN cord-010092-uftc8inx 4600 2 : : : cord-010092-uftc8inx 4601 1 The the DT cord-010092-uftc8inx 4601 2 Information Information NNP cord-010092-uftc8inx 4601 3 System System NNP cord-010092-uftc8inx 4601 4 on on IN cord-010092-uftc8inx 4601 5 Hemovigilance Hemovigilance NNP cord-010092-uftc8inx 4601 6 SIHEVI SIHEVI NNP cord-010092-uftc8inx 4601 7 - - HYPH cord-010092-uftc8inx 4601 8 INS INS NNP cord-010092-uftc8inx 4601 9 © © NN cord-010092-uftc8inx 4601 10 , , , cord-010092-uftc8inx 4601 11 coordinated coordinate VBN cord-010092-uftc8inx 4601 12 by by IN cord-010092-uftc8inx 4601 13 the the DT cord-010092-uftc8inx 4601 14 National National NNP cord-010092-uftc8inx 4601 15 Health Health NNP cord-010092-uftc8inx 4601 16 Institute Institute NNP cord-010092-uftc8inx 4601 17 was be VBD cord-010092-uftc8inx 4601 18 available available JJ cord-010092-uftc8inx 4601 19 in in IN cord-010092-uftc8inx 4601 20 2018 2018 CD cord-010092-uftc8inx 4601 21 to to IN cord-010092-uftc8inx 4601 22 all all DT cord-010092-uftc8inx 4601 23 blood blood NN cord-010092-uftc8inx 4601 24 banks bank NNS cord-010092-uftc8inx 4601 25 in in IN cord-010092-uftc8inx 4601 26 the the DT cord-010092-uftc8inx 4601 27 country country NN cord-010092-uftc8inx 4601 28 . . . cord-010092-uftc8inx 4602 1 This this DT cord-010092-uftc8inx 4602 2 software software NN cord-010092-uftc8inx 4602 3 allows allow VBZ cord-010092-uftc8inx 4602 4 to to TO cord-010092-uftc8inx 4602 5 centralize centralize VB cord-010092-uftc8inx 4602 6 and and CC cord-010092-uftc8inx 4602 7 record record VB cord-010092-uftc8inx 4602 8 the the DT cord-010092-uftc8inx 4602 9 identification identification NN cord-010092-uftc8inx 4602 10 data datum NNS cord-010092-uftc8inx 4602 11 of of IN cord-010092-uftc8inx 4602 12 a a DT cord-010092-uftc8inx 4602 13 donor donor NN cord-010092-uftc8inx 4602 14 , , , cord-010092-uftc8inx 4602 15 its -PRON- PRP$ cord-010092-uftc8inx 4602 16 infectious infectious JJ cord-010092-uftc8inx 4602 17 and and CC cord-010092-uftc8inx 4602 18 immunohematological immunohematological JJ cord-010092-uftc8inx 4602 19 tests test NNS cord-010092-uftc8inx 4602 20 , , , cord-010092-uftc8inx 4602 21 as as RB cord-010092-uftc8inx 4602 22 well well RB cord-010092-uftc8inx 4602 23 as as IN cord-010092-uftc8inx 4602 24 the the DT cord-010092-uftc8inx 4602 25 fractionation fractionation NN cord-010092-uftc8inx 4602 26 and and CC cord-010092-uftc8inx 4602 27 final final JJ cord-010092-uftc8inx 4602 28 destination destination NN cord-010092-uftc8inx 4602 29 of of IN cord-010092-uftc8inx 4602 30 each each DT cord-010092-uftc8inx 4602 31 blood blood NN cord-010092-uftc8inx 4602 32 component component NN cord-010092-uftc8inx 4602 33 obtained obtain VBN cord-010092-uftc8inx 4602 34 from from IN cord-010092-uftc8inx 4602 35 a a DT cord-010092-uftc8inx 4602 36 donor donor NN cord-010092-uftc8inx 4602 37 . . . cord-010092-uftc8inx 4603 1 Aims aim VBZ cord-010092-uftc8inx 4603 2 : : : cord-010092-uftc8inx 4603 3 To to TO cord-010092-uftc8inx 4603 4 describe describe VB cord-010092-uftc8inx 4603 5 the the DT cord-010092-uftc8inx 4603 6 ABO ABO NNP cord-010092-uftc8inx 4603 7 and and CC cord-010092-uftc8inx 4603 8 RhD rhd NN cord-010092-uftc8inx 4603 9 typing typing NN cord-010092-uftc8inx 4603 10 discrepancies discrepancy NNS cord-010092-uftc8inx 4603 11 in in IN cord-010092-uftc8inx 4603 12 blood blood NN cord-010092-uftc8inx 4603 13 donors donor NNS cord-010092-uftc8inx 4603 14 found find VBN cord-010092-uftc8inx 4603 15 in in IN cord-010092-uftc8inx 4603 16 the the DT cord-010092-uftc8inx 4603 17 blood blood NN cord-010092-uftc8inx 4603 18 group group NN cord-010092-uftc8inx 4603 19 variables variable NNS cord-010092-uftc8inx 4603 20 registered register VBN cord-010092-uftc8inx 4603 21 by by IN cord-010092-uftc8inx 4603 22 each each DT cord-010092-uftc8inx 4603 23 blood blood NN cord-010092-uftc8inx 4603 24 bank bank NN cord-010092-uftc8inx 4603 25 to to IN cord-010092-uftc8inx 4603 26 SIHEVI SIHEVI NNP cord-010092-uftc8inx 4603 27 - - HYPH cord-010092-uftc8inx 4603 28 INS INS NNP cord-010092-uftc8inx 4603 29 © © NN cord-010092-uftc8inx 4603 30 . . . cord-010092-uftc8inx 4604 1 Methods method NNS cord-010092-uftc8inx 4604 2 : : : cord-010092-uftc8inx 4604 3 Retrospective retrospective JJ cord-010092-uftc8inx 4604 4 analysis analysis NN cord-010092-uftc8inx 4604 5 of of IN cord-010092-uftc8inx 4604 6 the the DT cord-010092-uftc8inx 4604 7 information information NN cord-010092-uftc8inx 4604 8 registered register VBN cord-010092-uftc8inx 4604 9 by by IN cord-010092-uftc8inx 4604 10 80 80 CD cord-010092-uftc8inx 4604 11 of of IN cord-010092-uftc8inx 4604 12 the the DT cord-010092-uftc8inx 4604 13 81 81 CD cord-010092-uftc8inx 4604 14 blood blood NN cord-010092-uftc8inx 4604 15 banks bank NNS cord-010092-uftc8inx 4604 16 authorized authorize VBN cord-010092-uftc8inx 4604 17 nationwide nationwide RB cord-010092-uftc8inx 4604 18 between between IN cord-010092-uftc8inx 4604 19 January January NNP cord-010092-uftc8inx 4604 20 and and CC cord-010092-uftc8inx 4604 21 December December NNP cord-010092-uftc8inx 4604 22 2018 2018 CD cord-010092-uftc8inx 4604 23 . . . cord-010092-uftc8inx 4605 1 Results result NNS cord-010092-uftc8inx 4605 2 : : : cord-010092-uftc8inx 4606 1 SIHEVI SIHEVI NNP cord-010092-uftc8inx 4606 2 - - HYPH cord-010092-uftc8inx 4606 3 INS INS NNP cord-010092-uftc8inx 4606 4 © © NN cord-010092-uftc8inx 4606 5 received receive VBD cord-010092-uftc8inx 4606 6 information information NN cord-010092-uftc8inx 4606 7 of of IN cord-010092-uftc8inx 4606 8 854,462 854,462 CD cord-010092-uftc8inx 4606 9 accepted accept VBN cord-010092-uftc8inx 4606 10 donors donor NNS cord-010092-uftc8inx 4606 11 , , , cord-010092-uftc8inx 4606 12 33 33 CD cord-010092-uftc8inx 4606 13 % % NN cord-010092-uftc8inx 4606 14 of of IN cord-010092-uftc8inx 4606 15 them -PRON- PRP cord-010092-uftc8inx 4606 16 with with IN cord-010092-uftc8inx 4606 17 more more JJR cord-010092-uftc8inx 4606 18 than than IN cord-010092-uftc8inx 4606 19 one one CD cord-010092-uftc8inx 4606 20 donation donation NN cord-010092-uftc8inx 4606 21 in in IN cord-010092-uftc8inx 4606 22 the the DT cord-010092-uftc8inx 4606 23 same same JJ cord-010092-uftc8inx 4606 24 blood blood NN cord-010092-uftc8inx 4606 25 bank bank NN cord-010092-uftc8inx 4606 26 in in IN cord-010092-uftc8inx 4606 27 a a DT cord-010092-uftc8inx 4606 28 period period NN cord-010092-uftc8inx 4606 29 of of IN cord-010092-uftc8inx 4606 30 12 12 CD cord-010092-uftc8inx 4606 31 months month NNS cord-010092-uftc8inx 4606 32 . . . cord-010092-uftc8inx 4607 1 A a DT cord-010092-uftc8inx 4607 2 total total NN cord-010092-uftc8inx 4607 3 of of IN cord-010092-uftc8inx 4607 4 72 72 CD cord-010092-uftc8inx 4607 5 ABO ABO NNP cord-010092-uftc8inx 4607 6 or or CC cord-010092-uftc8inx 4607 7 RhD rhd NN cord-010092-uftc8inx 4607 8 discrepancies discrepancy NNS cord-010092-uftc8inx 4607 9 were be VBD cord-010092-uftc8inx 4607 10 identified identify VBN cord-010092-uftc8inx 4607 11 in in IN cord-010092-uftc8inx 4607 12 69 69 CD cord-010092-uftc8inx 4607 13 people people NNS cord-010092-uftc8inx 4607 14 , , , cord-010092-uftc8inx 4607 15 who who WP cord-010092-uftc8inx 4607 16 made make VBD cord-010092-uftc8inx 4607 17 donations donation NNS cord-010092-uftc8inx 4607 18 in in IN cord-010092-uftc8inx 4607 19 20 20 CD cord-010092-uftc8inx 4607 20 blood blood NN cord-010092-uftc8inx 4607 21 banks bank NNS cord-010092-uftc8inx 4607 22 ( ( -LRB- cord-010092-uftc8inx 4607 23 estimated estimate VBN cord-010092-uftc8inx 4607 24 risk risk NN cord-010092-uftc8inx 4607 25 : : : cord-010092-uftc8inx 4608 1 one one CD cord-010092-uftc8inx 4608 2 discrepancy discrepancy NN cord-010092-uftc8inx 4608 3 per per IN cord-010092-uftc8inx 4608 4 11,876 11,876 CD cord-010092-uftc8inx 4608 5 accepted accept VBN cord-010092-uftc8inx 4608 6 donors donor NNS cord-010092-uftc8inx 4608 7 ) ) -RRB- cord-010092-uftc8inx 4608 8 . . . cord-010092-uftc8inx 4609 1 Five five CD cord-010092-uftc8inx 4609 2 of of IN cord-010092-uftc8inx 4609 3 the the DT cord-010092-uftc8inx 4609 4 blood blood NN cord-010092-uftc8inx 4609 5 banks bank NNS cord-010092-uftc8inx 4609 6 implicated implicate VBN cord-010092-uftc8inx 4609 7 in in IN cord-010092-uftc8inx 4609 8 these these DT cord-010092-uftc8inx 4609 9 discrepancies discrepancy NNS cord-010092-uftc8inx 4609 10 are be VBP cord-010092-uftc8inx 4609 11 hospital hospital NN cord-010092-uftc8inx 4609 12 - - HYPH cord-010092-uftc8inx 4609 13 based base VBN cord-010092-uftc8inx 4609 14 ( ( -LRB- cord-010092-uftc8inx 4609 15 annual annual JJ cord-010092-uftc8inx 4609 16 average average JJ cord-010092-uftc8inx 4609 17 collection collection NN cord-010092-uftc8inx 4609 18 of of IN cord-010092-uftc8inx 4609 19 6,086 6,086 CD cord-010092-uftc8inx 4609 20 AE AE NNP cord-010092-uftc8inx 4609 21 3,785 3,785 CD cord-010092-uftc8inx 4609 22 units unit NNS cord-010092-uftc8inx 4609 23 , , , cord-010092-uftc8inx 4609 24 representing represent VBG cord-010092-uftc8inx 4609 25 3.6 3.6 CD cord-010092-uftc8inx 4609 26 % % NN cord-010092-uftc8inx 4609 27 of of IN cord-010092-uftc8inx 4609 28 the the DT cord-010092-uftc8inx 4609 29 national national JJ cord-010092-uftc8inx 4609 30 collect collect NNP cord-010092-uftc8inx 4609 31 ) ) -RRB- cord-010092-uftc8inx 4609 32 . . . cord-010092-uftc8inx 4610 1 The the DT cord-010092-uftc8inx 4610 2 remaining remain VBG cord-010092-uftc8inx 4610 3 blood blood NN cord-010092-uftc8inx 4610 4 banks bank NNS cord-010092-uftc8inx 4610 5 are be VBP cord-010092-uftc8inx 4610 6 distributors distributor NNS cord-010092-uftc8inx 4610 7 ( ( -LRB- cord-010092-uftc8inx 4610 8 average average JJ cord-010092-uftc8inx 4610 9 collection collection NN cord-010092-uftc8inx 4610 10 : : : cord-010092-uftc8inx 4611 1 31,389 31,389 CD cord-010092-uftc8inx 4611 2 AE AE NNP cord-010092-uftc8inx 4611 3 25,704 25,704 CD cord-010092-uftc8inx 4611 4 units unit NNS cord-010092-uftc8inx 4611 5 per per IN cord-010092-uftc8inx 4611 6 year year NN cord-010092-uftc8inx 4611 7 , , , cord-010092-uftc8inx 4611 8 representing represent VBG cord-010092-uftc8inx 4611 9 44 44 CD cord-010092-uftc8inx 4611 10 % % NN cord-010092-uftc8inx 4611 11 of of IN cord-010092-uftc8inx 4611 12 the the DT cord-010092-uftc8inx 4611 13 national national JJ cord-010092-uftc8inx 4611 14 collect collect NNP cord-010092-uftc8inx 4611 15 ) ) -RRB- cord-010092-uftc8inx 4611 16 . . . cord-010092-uftc8inx 4612 1 75 75 CD cord-010092-uftc8inx 4612 2 % % NN cord-010092-uftc8inx 4612 3 of of IN cord-010092-uftc8inx 4612 4 blood blood NN cord-010092-uftc8inx 4612 5 group group NN cord-010092-uftc8inx 4612 6 typing type VBG cord-010092-uftc8inx 4612 7 discrepancies discrepancy NNS cord-010092-uftc8inx 4612 8 ( ( -LRB- cord-010092-uftc8inx 4612 9 n n NN cord-010092-uftc8inx 4612 10 = = SYM cord-010092-uftc8inx 4612 11 36 36 CD cord-010092-uftc8inx 4612 12 ) ) -RRB- cord-010092-uftc8inx 4612 13 were be VBD cord-010092-uftc8inx 4612 14 related relate VBN cord-010092-uftc8inx 4612 15 to to IN cord-010092-uftc8inx 4612 16 the the DT cord-010092-uftc8inx 4612 17 ABO ABO NNP cord-010092-uftc8inx 4612 18 group group NN cord-010092-uftc8inx 4612 19 . . . cord-010092-uftc8inx 4613 1 The the DT cord-010092-uftc8inx 4613 2 most most RBS cord-010092-uftc8inx 4613 3 common common JJ cord-010092-uftc8inx 4613 4 discrepancy discrepancy NN cord-010092-uftc8inx 4613 5 was be VBD cord-010092-uftc8inx 4613 6 between between IN cord-010092-uftc8inx 4613 7 A a DT cord-010092-uftc8inx 4613 8 typing typing NN cord-010092-uftc8inx 4613 9 group group NN cord-010092-uftc8inx 4613 10 and and CC cord-010092-uftc8inx 4613 11 AB AB NNP cord-010092-uftc8inx 4613 12 typing typing NN cord-010092-uftc8inx 4613 13 group group NN cord-010092-uftc8inx 4613 14 ( ( -LRB- cord-010092-uftc8inx 4613 15 67 67 CD cord-010092-uftc8inx 4613 16 % % NN cord-010092-uftc8inx 4613 17 ) ) -RRB- cord-010092-uftc8inx 4613 18 . . . cord-010092-uftc8inx 4614 1 In in IN cord-010092-uftc8inx 4614 2 25 25 CD cord-010092-uftc8inx 4614 3 % % NN cord-010092-uftc8inx 4614 4 of of IN cord-010092-uftc8inx 4614 5 the the DT cord-010092-uftc8inx 4614 6 cases case NNS cord-010092-uftc8inx 4614 7 , , , cord-010092-uftc8inx 4614 8 the the DT cord-010092-uftc8inx 4614 9 same same JJ cord-010092-uftc8inx 4614 10 blood blood NN cord-010092-uftc8inx 4614 11 bank bank NN cord-010092-uftc8inx 4614 12 initially initially RB cord-010092-uftc8inx 4614 13 registered register VBD cord-010092-uftc8inx 4614 14 in in IN cord-010092-uftc8inx 4614 15 the the DT cord-010092-uftc8inx 4614 16 same same JJ cord-010092-uftc8inx 4614 17 donor donor NN cord-010092-uftc8inx 4614 18 , , , cord-010092-uftc8inx 4614 19 an an DT cord-010092-uftc8inx 4614 20 O o NN cord-010092-uftc8inx 4614 21 blood blood NN cord-010092-uftc8inx 4614 22 type type NN cord-010092-uftc8inx 4614 23 donation donation NN cord-010092-uftc8inx 4614 24 and and CC cord-010092-uftc8inx 4614 25 later later RBR cord-010092-uftc8inx 4614 26 an an DT cord-010092-uftc8inx 4614 27 A a DT cord-010092-uftc8inx 4614 28 blood blood NN cord-010092-uftc8inx 4614 29 type type NN cord-010092-uftc8inx 4614 30 ( ( -LRB- cord-010092-uftc8inx 4614 31 n n NN cord-010092-uftc8inx 4614 32 = = SYM cord-010092-uftc8inx 4614 33 10 10 CD cord-010092-uftc8inx 4614 34 ) ) -RRB- cord-010092-uftc8inx 4614 35 or or CC cord-010092-uftc8inx 4614 36 B b NN cord-010092-uftc8inx 4614 37 type type NN cord-010092-uftc8inx 4614 38 ( ( -LRB- cord-010092-uftc8inx 4614 39 n n NN cord-010092-uftc8inx 4614 40 = = SYM cord-010092-uftc8inx 4614 41 4 4 CD cord-010092-uftc8inx 4614 42 ) ) -RRB- cord-010092-uftc8inx 4614 43 . . . cord-010092-uftc8inx 4615 1 RhD RhD NNP cord-010092-uftc8inx 4615 2 typing type VBG cord-010092-uftc8inx 4615 3 discrepancies discrepancy NNS cord-010092-uftc8inx 4615 4 account account VBP cord-010092-uftc8inx 4615 5 for for IN cord-010092-uftc8inx 4615 6 25 25 CD cord-010092-uftc8inx 4615 7 % % NN cord-010092-uftc8inx 4615 8 ( ( -LRB- cord-010092-uftc8inx 4615 9 n n NN cord-010092-uftc8inx 4615 10 = = SYM cord-010092-uftc8inx 4615 11 18 18 CD cord-010092-uftc8inx 4615 12 ) ) -RRB- cord-010092-uftc8inx 4615 13 of of IN cord-010092-uftc8inx 4615 14 the the DT cord-010092-uftc8inx 4615 15 total total NN cord-010092-uftc8inx 4615 16 . . . cord-010092-uftc8inx 4616 1 Additionally additionally RB cord-010092-uftc8inx 4616 2 , , , cord-010092-uftc8inx 4616 3 in in IN cord-010092-uftc8inx 4616 4 three three CD cord-010092-uftc8inx 4616 5 donors donor NNS cord-010092-uftc8inx 4616 6 , , , cord-010092-uftc8inx 4616 7 a a DT cord-010092-uftc8inx 4616 8 simultaneous simultaneous JJ cord-010092-uftc8inx 4616 9 discrepancy discrepancy NN cord-010092-uftc8inx 4616 10 between between IN cord-010092-uftc8inx 4616 11 ABO ABO NNP cord-010092-uftc8inx 4616 12 and and CC cord-010092-uftc8inx 4616 13 RhD RhD NNP cord-010092-uftc8inx 4616 14 typing typing NN cord-010092-uftc8inx 4616 15 was be VBD cord-010092-uftc8inx 4616 16 detected detect VBN cord-010092-uftc8inx 4616 17 in in IN cord-010092-uftc8inx 4616 18 the the DT cord-010092-uftc8inx 4616 19 same same JJ cord-010092-uftc8inx 4616 20 blood blood NN cord-010092-uftc8inx 4616 21 bank bank NN cord-010092-uftc8inx 4616 22 . . . cord-010092-uftc8inx 4617 1 The the DT cord-010092-uftc8inx 4617 2 results result NNS cord-010092-uftc8inx 4617 3 could could MD cord-010092-uftc8inx 4617 4 be be VB cord-010092-uftc8inx 4617 5 due due JJ cord-010092-uftc8inx 4617 6 to to IN cord-010092-uftc8inx 4617 7 : : : cord-010092-uftc8inx 4617 8 a a LS cord-010092-uftc8inx 4617 9 ) ) -RRB- cord-010092-uftc8inx 4617 10 failure failure NN cord-010092-uftc8inx 4617 11 in in IN cord-010092-uftc8inx 4617 12 the the DT cord-010092-uftc8inx 4617 13 warning warning NN cord-010092-uftc8inx 4617 14 mechanism mechanism NN cord-010092-uftc8inx 4617 15 before before IN cord-010092-uftc8inx 4617 16 the the DT cord-010092-uftc8inx 4617 17 release release NN cord-010092-uftc8inx 4617 18 of of IN cord-010092-uftc8inx 4617 19 the the DT cord-010092-uftc8inx 4617 20 blood blood NN cord-010092-uftc8inx 4617 21 component component NN cord-010092-uftc8inx 4617 22 ; ; : cord-010092-uftc8inx 4617 23 b b LS cord-010092-uftc8inx 4617 24 ) ) -RRB- cord-010092-uftc8inx 4617 25 errors error NNS cord-010092-uftc8inx 4617 26 in in IN cord-010092-uftc8inx 4617 27 typing type VBG cord-010092-uftc8inx 4617 28 the the DT cord-010092-uftc8inx 4617 29 information information NN cord-010092-uftc8inx 4617 30 of of IN cord-010092-uftc8inx 4617 31 the the DT cord-010092-uftc8inx 4617 32 donor donor NN cord-010092-uftc8inx 4617 33 registered register VBN cord-010092-uftc8inx 4617 34 in in IN cord-010092-uftc8inx 4617 35 the the DT cord-010092-uftc8inx 4617 36 system system NN cord-010092-uftc8inx 4617 37 or or CC cord-010092-uftc8inx 4617 38 c c NN cord-010092-uftc8inx 4617 39 ) ) -RRB- cord-010092-uftc8inx 4617 40 failures failure NNS cord-010092-uftc8inx 4617 41 in in IN cord-010092-uftc8inx 4617 42 the the DT cord-010092-uftc8inx 4617 43 identification identification NN cord-010092-uftc8inx 4617 44 of of IN cord-010092-uftc8inx 4617 45 the the DT cord-010092-uftc8inx 4617 46 donors donor NNS cord-010092-uftc8inx 4617 47 at at IN cord-010092-uftc8inx 4617 48 the the DT cord-010092-uftc8inx 4617 49 time time NN cord-010092-uftc8inx 4617 50 of of IN cord-010092-uftc8inx 4617 51 selection selection NN cord-010092-uftc8inx 4617 52 . . . cord-010092-uftc8inx 4618 1 The the DT cord-010092-uftc8inx 4618 2 above above JJ cord-010092-uftc8inx 4618 3 shows show VBZ cord-010092-uftc8inx 4618 4 risk risk NN cord-010092-uftc8inx 4618 5 in in IN cord-010092-uftc8inx 4618 6 the the DT cord-010092-uftc8inx 4618 7 process process NN cord-010092-uftc8inx 4618 8 of of IN cord-010092-uftc8inx 4618 9 control control NN cord-010092-uftc8inx 4618 10 of of IN cord-010092-uftc8inx 4618 11 blood blood NN cord-010092-uftc8inx 4618 12 components component NNS cord-010092-uftc8inx 4618 13 release release NN cord-010092-uftc8inx 4618 14 , , , cord-010092-uftc8inx 4618 15 which which WDT cord-010092-uftc8inx 4618 16 can can MD cord-010092-uftc8inx 4618 17 impact impact VB cord-010092-uftc8inx 4618 18 patient patient JJ cord-010092-uftc8inx 4618 19 safety safety NN cord-010092-uftc8inx 4618 20 unless unless IN cord-010092-uftc8inx 4618 21 ABO ABO NNP cord-010092-uftc8inx 4618 22 and and CC cord-010092-uftc8inx 4618 23 RhD rhd NN cord-010092-uftc8inx 4618 24 typing type VBG cord-010092-uftc8inx 4618 25 blood blood NN cord-010092-uftc8inx 4618 26 groups group NNS cord-010092-uftc8inx 4618 27 are be VBP cord-010092-uftc8inx 4618 28 systematically systematically RB cord-010092-uftc8inx 4618 29 verified verify VBN cord-010092-uftc8inx 4618 30 before before IN cord-010092-uftc8inx 4618 31 transfusion transfusion NN cord-010092-uftc8inx 4618 32 . . . cord-010092-uftc8inx 4619 1 Summary Summary NNP cord-010092-uftc8inx 4619 2 / / SYM cord-010092-uftc8inx 4619 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 4619 4 : : : cord-010092-uftc8inx 4620 1 Despite despite IN cord-010092-uftc8inx 4620 2 blood blood NN cord-010092-uftc8inx 4620 3 banks bank NNS cord-010092-uftc8inx 4620 4 have have VBP cord-010092-uftc8inx 4620 5 a a DT cord-010092-uftc8inx 4620 6 verification verification NN cord-010092-uftc8inx 4620 7 and and CC cord-010092-uftc8inx 4620 8 validation validation NN cord-010092-uftc8inx 4620 9 process process NN cord-010092-uftc8inx 4620 10 through through IN cord-010092-uftc8inx 4620 11 software software NN cord-010092-uftc8inx 4620 12 to to TO cord-010092-uftc8inx 4620 13 release release VB cord-010092-uftc8inx 4620 14 blood blood NN cord-010092-uftc8inx 4620 15 components component NNS cord-010092-uftc8inx 4620 16 , , , cord-010092-uftc8inx 4620 17 flaws flaw NNS cord-010092-uftc8inx 4620 18 were be VBD cord-010092-uftc8inx 4620 19 detected detect VBN cord-010092-uftc8inx 4620 20 . . . cord-010092-uftc8inx 4621 1 Although although IN cord-010092-uftc8inx 4621 2 SIHEVI SIHEVI NNP cord-010092-uftc8inx 4621 3 - - HYPH cord-010092-uftc8inx 4621 4 INS INS NNP cord-010092-uftc8inx 4621 5 © © NN cord-010092-uftc8inx 4621 6 is be VBZ cord-010092-uftc8inx 4621 7 not not RB cord-010092-uftc8inx 4621 8 a a DT cord-010092-uftc8inx 4621 9 software software NN cord-010092-uftc8inx 4621 10 to to TO cord-010092-uftc8inx 4621 11 validate validate VB cord-010092-uftc8inx 4621 12 the the DT cord-010092-uftc8inx 4621 13 information information NN cord-010092-uftc8inx 4621 14 before before IN cord-010092-uftc8inx 4621 15 the the DT cord-010092-uftc8inx 4621 16 release release NN cord-010092-uftc8inx 4621 17 of of IN cord-010092-uftc8inx 4621 18 blood blood NN cord-010092-uftc8inx 4621 19 components component NNS cord-010092-uftc8inx 4621 20 , , , cord-010092-uftc8inx 4621 21 it -PRON- PRP cord-010092-uftc8inx 4621 22 was be VBD cord-010092-uftc8inx 4621 23 through through IN cord-010092-uftc8inx 4621 24 this this DT cord-010092-uftc8inx 4621 25 program program NN cord-010092-uftc8inx 4621 26 that that IN cord-010092-uftc8inx 4621 27 ABO ABO NNP cord-010092-uftc8inx 4621 28 and and CC cord-010092-uftc8inx 4621 29 RhD rhd NN cord-010092-uftc8inx 4621 30 typing typing NN cord-010092-uftc8inx 4621 31 discrepancies discrepancy NNS cord-010092-uftc8inx 4621 32 were be VBD cord-010092-uftc8inx 4621 33 identified identify VBN cord-010092-uftc8inx 4621 34 in in IN cord-010092-uftc8inx 4621 35 donors donor NNS cord-010092-uftc8inx 4621 36 who who WP cord-010092-uftc8inx 4621 37 attended attend VBD cord-010092-uftc8inx 4621 38 the the DT cord-010092-uftc8inx 4621 39 same same JJ cord-010092-uftc8inx 4621 40 blood blood NN cord-010092-uftc8inx 4621 41 bank bank NN cord-010092-uftc8inx 4621 42 multiple multiple JJ cord-010092-uftc8inx 4621 43 times time NNS cord-010092-uftc8inx 4621 44 . . . cord-010092-uftc8inx 4622 1 This this DT cord-010092-uftc8inx 4622 2 finding finding NN cord-010092-uftc8inx 4622 3 implies imply VBZ cord-010092-uftc8inx 4622 4 increasing increase VBG cord-010092-uftc8inx 4622 5 the the DT cord-010092-uftc8inx 4622 6 controls control NNS cord-010092-uftc8inx 4622 7 that that WDT cord-010092-uftc8inx 4622 8 should should MD cord-010092-uftc8inx 4622 9 be be VB cord-010092-uftc8inx 4622 10 used use VBN cord-010092-uftc8inx 4622 11 in in IN cord-010092-uftc8inx 4622 12 each each DT cord-010092-uftc8inx 4622 13 blood blood NN cord-010092-uftc8inx 4622 14 bank bank NN cord-010092-uftc8inx 4622 15 , , , cord-010092-uftc8inx 4622 16 to to TO cord-010092-uftc8inx 4622 17 avoid avoid VB cord-010092-uftc8inx 4622 18 lose lose VB cord-010092-uftc8inx 4622 19 traceability traceability NN cord-010092-uftc8inx 4622 20 of of IN cord-010092-uftc8inx 4622 21 the the DT cord-010092-uftc8inx 4622 22 processes process NNS cord-010092-uftc8inx 4622 23 and and CC cord-010092-uftc8inx 4622 24 to to TO cord-010092-uftc8inx 4622 25 put put VB cord-010092-uftc8inx 4622 26 at at IN cord-010092-uftc8inx 4622 27 risk risk NN cord-010092-uftc8inx 4622 28 the the DT cord-010092-uftc8inx 4622 29 life life NN cord-010092-uftc8inx 4622 30 of of IN cord-010092-uftc8inx 4622 31 the the DT cord-010092-uftc8inx 4622 32 recipients recipient NNS cord-010092-uftc8inx 4622 33 . . . cord-010092-uftc8inx 4623 1 Blood blood NN cord-010092-uftc8inx 4623 2 donor donor NN cord-010092-uftc8inx 4623 3 testing testing NN cord-010092-uftc8inx 4623 4 department department NN cord-010092-uftc8inx 4623 5 , , , cord-010092-uftc8inx 4623 6 Blood Blood NNP cord-010092-uftc8inx 4623 7 transfusion transfusion NN cord-010092-uftc8inx 4623 8 institute institute NN cord-010092-uftc8inx 4623 9 of of IN cord-010092-uftc8inx 4623 10 Nis Nis NNP cord-010092-uftc8inx 4623 11 , , , cord-010092-uftc8inx 4623 12 Nis Nis NNP cord-010092-uftc8inx 4623 13 , , , cord-010092-uftc8inx 4624 1 Serbia Serbia NNP cord-010092-uftc8inx 4624 2 Background Background NNP cord-010092-uftc8inx 4624 3 : : : cord-010092-uftc8inx 4625 1 The the DT cord-010092-uftc8inx 4625 2 ability ability NN cord-010092-uftc8inx 4625 3 to to TO cord-010092-uftc8inx 4625 4 automate automate VB cord-010092-uftc8inx 4625 5 blood blood NN cord-010092-uftc8inx 4625 6 grouping grouping NN cord-010092-uftc8inx 4625 7 and and CC cord-010092-uftc8inx 4625 8 antibody antibody NN cord-010092-uftc8inx 4625 9 detection detection NN cord-010092-uftc8inx 4625 10 procedures procedure NNS cord-010092-uftc8inx 4625 11 is be VBZ cord-010092-uftc8inx 4625 12 a a DT cord-010092-uftc8inx 4625 13 requirement requirement NN cord-010092-uftc8inx 4625 14 for for IN cord-010092-uftc8inx 4625 15 blood blood NN cord-010092-uftc8inx 4625 16 donor donor NN cord-010092-uftc8inx 4625 17 testing testing NN cord-010092-uftc8inx 4625 18 laboratories laboratory NNS cord-010092-uftc8inx 4625 19 . . . cord-010092-uftc8inx 4626 1 Mistakes mistake NNS cord-010092-uftc8inx 4626 2 in in IN cord-010092-uftc8inx 4626 3 the the DT cord-010092-uftc8inx 4626 4 sample sample NN cord-010092-uftc8inx 4626 5 identification identification NN cord-010092-uftc8inx 4626 6 and and CC cord-010092-uftc8inx 4626 7 testing testing NN cord-010092-uftc8inx 4626 8 procedures procedure NNS cord-010092-uftc8inx 4626 9 could could MD cord-010092-uftc8inx 4626 10 be be VB cord-010092-uftc8inx 4626 11 prevented prevent VBN cord-010092-uftc8inx 4626 12 by by IN cord-010092-uftc8inx 4626 13 testing test VBG cord-010092-uftc8inx 4626 14 on on IN cord-010092-uftc8inx 4626 15 automated automate VBN cord-010092-uftc8inx 4626 16 immuno immuno JJ cord-010092-uftc8inx 4626 17 - - JJ cord-010092-uftc8inx 4626 18 hematology hematology JJ cord-010092-uftc8inx 4626 19 systems system NNS cord-010092-uftc8inx 4626 20 . . . cord-010092-uftc8inx 4627 1 Irregular irregular JJ cord-010092-uftc8inx 4627 2 antibody antibody NN cord-010092-uftc8inx 4627 3 screening screening NN cord-010092-uftc8inx 4627 4 and and CC cord-010092-uftc8inx 4627 5 ABO ABO NNP cord-010092-uftc8inx 4627 6 / / SYM cord-010092-uftc8inx 4627 7 RhD rhd NN cord-010092-uftc8inx 4627 8 grouping grouping NN cord-010092-uftc8inx 4627 9 of of IN cord-010092-uftc8inx 4627 10 blood blood NN cord-010092-uftc8inx 4627 11 donors donor NNS cord-010092-uftc8inx 4627 12 are be VBP cord-010092-uftc8inx 4627 13 tests test NNS cord-010092-uftc8inx 4627 14 performed perform VBN cord-010092-uftc8inx 4627 15 routinely routinely RB cord-010092-uftc8inx 4627 16 in in IN cord-010092-uftc8inx 4627 17 Blood Blood NNP cord-010092-uftc8inx 4627 18 transfusion transfusion NN cord-010092-uftc8inx 4627 19 institute institute NN cord-010092-uftc8inx 4627 20 of of IN cord-010092-uftc8inx 4627 21 Nis Nis NNP cord-010092-uftc8inx 4627 22 . . . cord-010092-uftc8inx 4628 1 NEO NEO NNP cord-010092-uftc8inx 4628 2 Iris Iris NNP cord-010092-uftc8inx 4628 3 ( ( -LRB- cord-010092-uftc8inx 4628 4 Immucor Immucor NNP cord-010092-uftc8inx 4628 5 , , , cord-010092-uftc8inx 4628 6 USA USA NNP cord-010092-uftc8inx 4628 7 ) ) -RRB- cord-010092-uftc8inx 4628 8 is be VBZ cord-010092-uftc8inx 4628 9 a a DT cord-010092-uftc8inx 4628 10 fully fully RB cord-010092-uftc8inx 4628 11 automated automate VBN cord-010092-uftc8inx 4628 12 instrument instrument NN cord-010092-uftc8inx 4628 13 for for IN cord-010092-uftc8inx 4628 14 the the DT cord-010092-uftc8inx 4628 15 ABO ABO NNP cord-010092-uftc8inx 4628 16 and and CC cord-010092-uftc8inx 4628 17 Rh Rh NNP cord-010092-uftc8inx 4628 18 D D NNP cord-010092-uftc8inx 4628 19 grouping grouping NN cord-010092-uftc8inx 4628 20 using use VBG cord-010092-uftc8inx 4628 21 microplate microplate NNP cord-010092-uftc8inx 4628 22 hemagglutination hemagglutination NN cord-010092-uftc8inx 4628 23 technique technique NN cord-010092-uftc8inx 4628 24 and and CC cord-010092-uftc8inx 4628 25 antibody antibody NN cord-010092-uftc8inx 4628 26 screening screening NN cord-010092-uftc8inx 4628 27 and and CC cord-010092-uftc8inx 4628 28 identification identification NN cord-010092-uftc8inx 4628 29 using use VBG cord-010092-uftc8inx 4628 30 Solid Solid NNP cord-010092-uftc8inx 4628 31 Phase Phase NNP cord-010092-uftc8inx 4628 32 Red red JJ cord-010092-uftc8inx 4628 33 Cell cell NN cord-010092-uftc8inx 4628 34 Adherence adherence NN cord-010092-uftc8inx 4628 35 ( ( -LRB- cord-010092-uftc8inx 4628 36 SPRCA SPRCA NNP cord-010092-uftc8inx 4628 37 ) ) -RRB- cord-010092-uftc8inx 4628 38 . . . cord-010092-uftc8inx 4629 1 Aims aim VBZ cord-010092-uftc8inx 4629 2 : : : cord-010092-uftc8inx 4629 3 Evaluation evaluation NN cord-010092-uftc8inx 4629 4 of of IN cord-010092-uftc8inx 4629 5 the the DT cord-010092-uftc8inx 4629 6 automated automate VBN cord-010092-uftc8inx 4629 7 NEO NEO NNP cord-010092-uftc8inx 4629 8 Iris Iris NNP cord-010092-uftc8inx 4629 9 system system NN cord-010092-uftc8inx 4629 10 for for IN cord-010092-uftc8inx 4629 11 ABO ABO NNP cord-010092-uftc8inx 4629 12 and and CC cord-010092-uftc8inx 4629 13 D D NNP cord-010092-uftc8inx 4629 14 grouping grouping NN cord-010092-uftc8inx 4629 15 and and CC cord-010092-uftc8inx 4629 16 irregular irregular JJ cord-010092-uftc8inx 4629 17 antibody antibody NN cord-010092-uftc8inx 4629 18 screening screening NN cord-010092-uftc8inx 4629 19 of of IN cord-010092-uftc8inx 4629 20 blood blood NN cord-010092-uftc8inx 4629 21 donors donor NNS cord-010092-uftc8inx 4629 22 in in IN cord-010092-uftc8inx 4629 23 Blood Blood NNP cord-010092-uftc8inx 4629 24 transfusion transfusion NN cord-010092-uftc8inx 4629 25 institute institute NN cord-010092-uftc8inx 4629 26 of of IN cord-010092-uftc8inx 4629 27 Nis Nis NNP cord-010092-uftc8inx 4629 28 . . . cord-010092-uftc8inx 4630 1 Methods method NNS cord-010092-uftc8inx 4630 2 : : : cord-010092-uftc8inx 4630 3 During during IN cord-010092-uftc8inx 4630 4 the the DT cord-010092-uftc8inx 4630 5 evaluation evaluation NN cord-010092-uftc8inx 4630 6 period period NN cord-010092-uftc8inx 4630 7 a a DT cord-010092-uftc8inx 4630 8 total total NN cord-010092-uftc8inx 4630 9 of of IN cord-010092-uftc8inx 4630 10 4417 4417 CD cord-010092-uftc8inx 4630 11 EDTA EDTA NNP cord-010092-uftc8inx 4630 12 - - HYPH cord-010092-uftc8inx 4630 13 anticoagulated anticoagulate VBN cord-010092-uftc8inx 4630 14 samples sample NNS cord-010092-uftc8inx 4630 15 for for IN cord-010092-uftc8inx 4630 16 ABO ABO NNP cord-010092-uftc8inx 4630 17 and and CC cord-010092-uftc8inx 4630 18 D D NNP cord-010092-uftc8inx 4630 19 forward forward RB cord-010092-uftc8inx 4630 20 and and CC cord-010092-uftc8inx 4630 21 reverse reverse VB cord-010092-uftc8inx 4630 22 grouping group VBG cord-010092-uftc8inx 4630 23 using use VBG cord-010092-uftc8inx 4630 24 microplate microplate NNP cord-010092-uftc8inx 4630 25 anti anti NNP cord-010092-uftc8inx 4630 26 - - NNP cord-010092-uftc8inx 4630 27 s s NNP cord-010092-uftc8inx 4630 28 , , , cord-010092-uftc8inx 4630 29 1 1 CD cord-010092-uftc8inx 4630 30 anti anti NNP cord-010092-uftc8inx 4630 31 - - NNP cord-010092-uftc8inx 4630 32 S S NNP cord-010092-uftc8inx 4630 33 , , , cord-010092-uftc8inx 4630 34 1 1 CD cord-010092-uftc8inx 4630 35 anti anti NNP cord-010092-uftc8inx 4630 36 - - NNP cord-010092-uftc8inx 4630 37 Jka Jka NNP cord-010092-uftc8inx 4630 38 and and CC cord-010092-uftc8inx 4630 39 6 6 CD cord-010092-uftc8inx 4630 40 anti anti JJ cord-010092-uftc8inx 4630 41 - - NNP cord-010092-uftc8inx 4630 42 K. K. NNP cord-010092-uftc8inx 4630 43 In in IN cord-010092-uftc8inx 4630 44 one one CD cord-010092-uftc8inx 4630 45 case case NN cord-010092-uftc8inx 4630 46 IH-1000 ih-1000 NN cord-010092-uftc8inx 4630 47 failed fail VBD cord-010092-uftc8inx 4630 48 to to TO cord-010092-uftc8inx 4630 49 identify identify VB cord-010092-uftc8inx 4630 50 anti anti JJ cord-010092-uftc8inx 4630 51 - - JJ cord-010092-uftc8inx 4630 52 C c JJ cord-010092-uftc8inx 4630 53 antibody antibody NN cord-010092-uftc8inx 4630 54 in in IN cord-010092-uftc8inx 4630 55 very very RB cord-010092-uftc8inx 4630 56 low low JJ cord-010092-uftc8inx 4630 57 titer titer NN cord-010092-uftc8inx 4630 58 in in IN cord-010092-uftc8inx 4630 59 sample sample NN cord-010092-uftc8inx 4630 60 with with IN cord-010092-uftc8inx 4630 61 anti anti JJ cord-010092-uftc8inx 4630 62 C+D C+D NNP cord-010092-uftc8inx 4630 63 antibody antibody NN cord-010092-uftc8inx 4630 64 presence presence NN cord-010092-uftc8inx 4630 65 . . . cord-010092-uftc8inx 4631 1 In in IN cord-010092-uftc8inx 4631 2 two two CD cord-010092-uftc8inx 4631 3 samples sample NNS cord-010092-uftc8inx 4631 4 ( ( -LRB- cord-010092-uftc8inx 4631 5 0.045 0.045 CD cord-010092-uftc8inx 4631 6 % % NN cord-010092-uftc8inx 4631 7 ) ) -RRB- cord-010092-uftc8inx 4631 8 false false JJ cord-010092-uftc8inx 4631 9 - - HYPH cord-010092-uftc8inx 4631 10 positive positive JJ cord-010092-uftc8inx 4631 11 result result NN cord-010092-uftc8inx 4631 12 were be VBD cord-010092-uftc8inx 4631 13 observed observe VBN cord-010092-uftc8inx 4631 14 both both CC cord-010092-uftc8inx 4631 15 on on IN cord-010092-uftc8inx 4631 16 IH-1000 IH-1000 NNP cord-010092-uftc8inx 4631 17 system system NN cord-010092-uftc8inx 4631 18 and and CC cord-010092-uftc8inx 4631 19 NEO NEO NNP cord-010092-uftc8inx 4631 20 Iris Iris NNP cord-010092-uftc8inx 4631 21 and and CC cord-010092-uftc8inx 4631 22 in in IN cord-010092-uftc8inx 4631 23 two two CD cord-010092-uftc8inx 4631 24 cases case NNS cord-010092-uftc8inx 4631 25 ( ( -LRB- cord-010092-uftc8inx 4631 26 0.09%)only 0.09%)only NN cord-010092-uftc8inx 4631 27 on on IN cord-010092-uftc8inx 4631 28 Neo Neo NNP cord-010092-uftc8inx 4631 29 Iris Iris NNP cord-010092-uftc8inx 4631 30 due due JJ cord-010092-uftc8inx 4631 31 to to IN cord-010092-uftc8inx 4631 32 nonspecific nonspecific JJ cord-010092-uftc8inx 4631 33 reasons reason NNS cord-010092-uftc8inx 4631 34 . . . cord-010092-uftc8inx 4632 1 Summary Summary NNP cord-010092-uftc8inx 4632 2 / / SYM cord-010092-uftc8inx 4632 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 4632 4 : : : cord-010092-uftc8inx 4633 1 ABO ABO NNP cord-010092-uftc8inx 4633 2 / / SYM cord-010092-uftc8inx 4633 3 RhD rhd NN cord-010092-uftc8inx 4633 4 grouping grouping NN cord-010092-uftc8inx 4633 5 results result NNS cord-010092-uftc8inx 4633 6 obtained obtain VBN cord-010092-uftc8inx 4633 7 on on IN cord-010092-uftc8inx 4633 8 NEO NEO NNP cord-010092-uftc8inx 4633 9 Iris Iris NNP cord-010092-uftc8inx 4633 10 system system NN cord-010092-uftc8inx 4633 11 , , , cord-010092-uftc8inx 4633 12 using use VBG cord-010092-uftc8inx 4633 13 microplate microplate NN cord-010092-uftc8inx 4633 14 method method NN cord-010092-uftc8inx 4633 15 , , , cord-010092-uftc8inx 4633 16 have have VBP cord-010092-uftc8inx 4633 17 a a DT cord-010092-uftc8inx 4633 18 good good JJ cord-010092-uftc8inx 4633 19 correlation correlation NN cord-010092-uftc8inx 4633 20 with with IN cord-010092-uftc8inx 4633 21 results result NNS cord-010092-uftc8inx 4633 22 on on IN cord-010092-uftc8inx 4633 23 IH-1000 ih-1000 NN cord-010092-uftc8inx 4633 24 system system NN cord-010092-uftc8inx 4633 25 as as IN cord-010092-uftc8inx 4633 26 our -PRON- PRP$ cord-010092-uftc8inx 4633 27 routine routine JJ cord-010092-uftc8inx 4633 28 column column NN cord-010092-uftc8inx 4633 29 agglutination agglutination NN cord-010092-uftc8inx 4633 30 method method NN cord-010092-uftc8inx 4633 31 . . . cord-010092-uftc8inx 4634 1 For for IN cord-010092-uftc8inx 4634 2 antibody antibody NN cord-010092-uftc8inx 4634 3 screening screening NN cord-010092-uftc8inx 4634 4 and and CC cord-010092-uftc8inx 4634 5 identification identification NN cord-010092-uftc8inx 4634 6 NEO NEO NNP cord-010092-uftc8inx 4634 7 Iris Iris NNP cord-010092-uftc8inx 4634 8 showed show VBD cord-010092-uftc8inx 4634 9 high high JJ cord-010092-uftc8inx 4634 10 sensitivity sensitivity NN cord-010092-uftc8inx 4634 11 for for IN cord-010092-uftc8inx 4634 12 detection detection NN cord-010092-uftc8inx 4634 13 of of IN cord-010092-uftc8inx 4634 14 clinically clinically RB cord-010092-uftc8inx 4634 15 significant significant JJ cord-010092-uftc8inx 4634 16 antibodies antibody NNS cord-010092-uftc8inx 4634 17 which which WDT cord-010092-uftc8inx 4634 18 is be VBZ cord-010092-uftc8inx 4634 19 important important JJ cord-010092-uftc8inx 4634 20 step step NN cord-010092-uftc8inx 4634 21 for for IN cord-010092-uftc8inx 4634 22 increasing increase VBG cord-010092-uftc8inx 4634 23 blood blood NN cord-010092-uftc8inx 4634 24 transfusion transfusion NN cord-010092-uftc8inx 4634 25 safety safety NN cord-010092-uftc8inx 4634 26 . . . cord-010092-uftc8inx 4635 1 Background background NN cord-010092-uftc8inx 4635 2 : : : cord-010092-uftc8inx 4636 1 Continuing continue VBG cord-010092-uftc8inx 4636 2 improvement improvement NN cord-010092-uftc8inx 4636 3 of of IN cord-010092-uftc8inx 4636 4 laboratory laboratory NN cord-010092-uftc8inx 4636 5 quality quality NN cord-010092-uftc8inx 4636 6 to to TO cord-010092-uftc8inx 4636 7 provide provide VB cord-010092-uftc8inx 4636 8 accuracy accuracy NN cord-010092-uftc8inx 4636 9 test test NN cord-010092-uftc8inx 4636 10 results result NNS cord-010092-uftc8inx 4636 11 for for IN cord-010092-uftc8inx 4636 12 precise precise JJ cord-010092-uftc8inx 4636 13 diagnosis diagnosis NN cord-010092-uftc8inx 4636 14 and and CC cord-010092-uftc8inx 4636 15 treatment treatment NN cord-010092-uftc8inx 4636 16 is be VBZ cord-010092-uftc8inx 4636 17 the the DT cord-010092-uftc8inx 4636 18 mission mission NN cord-010092-uftc8inx 4636 19 of of IN cord-010092-uftc8inx 4636 20 advanced advanced JJ cord-010092-uftc8inx 4636 21 laboratory laboratory NN cord-010092-uftc8inx 4636 22 . . . cord-010092-uftc8inx 4637 1 Immunogenetic immunogenetic JJ cord-010092-uftc8inx 4637 2 testing testing NN cord-010092-uftc8inx 4637 3 for for IN cord-010092-uftc8inx 4637 4 Histocompatibility Histocompatibility NNP cord-010092-uftc8inx 4637 5 including include VBG cord-010092-uftc8inx 4637 6 human human JJ cord-010092-uftc8inx 4637 7 leukocyte leukocyte NN cord-010092-uftc8inx 4637 8 antigen antigen NN cord-010092-uftc8inx 4637 9 ( ( -LRB- cord-010092-uftc8inx 4637 10 HLA HLA NNP cord-010092-uftc8inx 4637 11 ) ) -RRB- cord-010092-uftc8inx 4637 12 typing typing NN cord-010092-uftc8inx 4637 13 , , , cord-010092-uftc8inx 4637 14 HLA HLA NNP cord-010092-uftc8inx 4637 15 antibody antibody NN cord-010092-uftc8inx 4637 16 detection detection NN cord-010092-uftc8inx 4637 17 and and CC cord-010092-uftc8inx 4637 18 Cytotoxicity Cytotoxicity NNP cord-010092-uftc8inx 4637 19 test test NN cord-010092-uftc8inx 4637 20 is be VBZ cord-010092-uftc8inx 4637 21 critical critical JJ cord-010092-uftc8inx 4637 22 for for IN cord-010092-uftc8inx 4637 23 diagnosis diagnosis NN cord-010092-uftc8inx 4637 24 and and CC cord-010092-uftc8inx 4637 25 evaluation evaluation NN cord-010092-uftc8inx 4637 26 of of IN cord-010092-uftc8inx 4637 27 transplantation transplantation NN cord-010092-uftc8inx 4637 28 and and CC cord-010092-uftc8inx 4637 29 prognosis prognosis NN cord-010092-uftc8inx 4637 30 monitoring monitoring NN cord-010092-uftc8inx 4637 31 . . . cord-010092-uftc8inx 4638 1 In in IN cord-010092-uftc8inx 4638 2 order order NN cord-010092-uftc8inx 4638 3 to to TO cord-010092-uftc8inx 4638 4 improve improve VB cord-010092-uftc8inx 4638 5 the the DT cord-010092-uftc8inx 4638 6 quality quality NN cord-010092-uftc8inx 4638 7 of of IN cord-010092-uftc8inx 4638 8 experiment experiment NN cord-010092-uftc8inx 4638 9 competency competency NN cord-010092-uftc8inx 4638 10 , , , cord-010092-uftc8inx 4638 11 an an DT cord-010092-uftc8inx 4638 12 external external JJ cord-010092-uftc8inx 4638 13 quality quality NN cord-010092-uftc8inx 4638 14 assurance assurance NN cord-010092-uftc8inx 4638 15 schemes scheme NNS cord-010092-uftc8inx 4638 16 with with IN cord-010092-uftc8inx 4638 17 review review NN cord-010092-uftc8inx 4638 18 and and CC cord-010092-uftc8inx 4638 19 education education NN cord-010092-uftc8inx 4638 20 per per IN cord-010092-uftc8inx 4638 21 year year NN cord-010092-uftc8inx 4638 22 program program NN cord-010092-uftc8inx 4638 23 was be VBD cord-010092-uftc8inx 4638 24 established establish VBN cord-010092-uftc8inx 4638 25 and and CC cord-010092-uftc8inx 4638 26 performed perform VBN cord-010092-uftc8inx 4638 27 during during IN cord-010092-uftc8inx 4638 28 the the DT cord-010092-uftc8inx 4638 29 period period NN cord-010092-uftc8inx 4638 30 from from IN cord-010092-uftc8inx 4638 31 2017 2017 CD cord-010092-uftc8inx 4638 32 to to IN cord-010092-uftc8inx 4638 33 2018 2018 CD cord-010092-uftc8inx 4638 34 in in IN cord-010092-uftc8inx 4638 35 Taiwan Taiwan NNP cord-010092-uftc8inx 4638 36 . . . cord-010092-uftc8inx 4639 1 Aims aim VBZ cord-010092-uftc8inx 4639 2 : : : cord-010092-uftc8inx 4640 1 The the DT cord-010092-uftc8inx 4640 2 proficiency proficiency NN cord-010092-uftc8inx 4640 3 testing testing NN cord-010092-uftc8inx 4640 4 ( ( -LRB- cord-010092-uftc8inx 4640 5 PT pt NN cord-010092-uftc8inx 4640 6 ) ) -RRB- cord-010092-uftc8inx 4640 7 held hold VBN cord-010092-uftc8inx 4640 8 semiannually semiannually RB cord-010092-uftc8inx 4640 9 from from IN cord-010092-uftc8inx 4640 10 2017 2017 CD cord-010092-uftc8inx 4640 11 to to IN cord-010092-uftc8inx 4640 12 2018 2018 CD cord-010092-uftc8inx 4640 13 were be VBD cord-010092-uftc8inx 4640 14 reviewed review VBN cord-010092-uftc8inx 4640 15 to to TO cord-010092-uftc8inx 4640 16 investigate investigate VB cord-010092-uftc8inx 4640 17 the the DT cord-010092-uftc8inx 4640 18 outcome outcome NN cord-010092-uftc8inx 4640 19 of of IN cord-010092-uftc8inx 4640 20 competency competency NN cord-010092-uftc8inx 4640 21 improvement improvement NN cord-010092-uftc8inx 4640 22 of of IN cord-010092-uftc8inx 4640 23 laboratories laboratory NNS cord-010092-uftc8inx 4640 24 participated participate VBN cord-010092-uftc8inx 4640 25 in in IN cord-010092-uftc8inx 4640 26 the the DT cord-010092-uftc8inx 4640 27 program program NN cord-010092-uftc8inx 4640 28 . . . cord-010092-uftc8inx 4641 1 Methods method NNS cord-010092-uftc8inx 4641 2 : : : cord-010092-uftc8inx 4641 3 The the DT cord-010092-uftc8inx 4641 4 Test test NN cord-010092-uftc8inx 4641 5 items item NNS cord-010092-uftc8inx 4641 6 in in IN cord-010092-uftc8inx 4641 7 the the DT cord-010092-uftc8inx 4641 8 exercises exercise NNS cord-010092-uftc8inx 4641 9 were be VBD cord-010092-uftc8inx 4641 10 classified classify VBN cord-010092-uftc8inx 4641 11 into into IN cord-010092-uftc8inx 4641 12 4 4 CD cord-010092-uftc8inx 4641 13 groups group NNS cord-010092-uftc8inx 4641 14 , , , cord-010092-uftc8inx 4641 15 HLA HLA NNP cord-010092-uftc8inx 4641 16 genotyping genotyping NN cord-010092-uftc8inx 4641 17 ( ( -LRB- cord-010092-uftc8inx 4641 18 including include VBG cord-010092-uftc8inx 4641 19 pharmacogenetics pharmacogenetic NNS cord-010092-uftc8inx 4641 20 HLA HLA NNP cord-010092-uftc8inx 4641 21 typing typing NN cord-010092-uftc8inx 4641 22 ) ) -RRB- cord-010092-uftc8inx 4641 23 , , , cord-010092-uftc8inx 4641 24 Cytotoxicity Cytotoxicity NNP cord-010092-uftc8inx 4641 25 test test NN cord-010092-uftc8inx 4641 26 , , , cord-010092-uftc8inx 4641 27 HLA HLA NNP cord-010092-uftc8inx 4641 28 and and CC cord-010092-uftc8inx 4641 29 Platelet Platelet NNP cord-010092-uftc8inx 4641 30 antibody antibody NN cord-010092-uftc8inx 4641 31 . . . cord-010092-uftc8inx 4642 1 The the DT cord-010092-uftc8inx 4642 2 methods method NNS cord-010092-uftc8inx 4642 3 of of IN cord-010092-uftc8inx 4642 4 HLA HLA NNP cord-010092-uftc8inx 4642 5 genotyping genotyping NN cord-010092-uftc8inx 4642 6 include include VBP cord-010092-uftc8inx 4642 7 SSP SSP NNP cord-010092-uftc8inx 4642 8 ( ( -LRB- cord-010092-uftc8inx 4642 9 Sequence Sequence NNP cord-010092-uftc8inx 4642 10 Specific Specific NNP cord-010092-uftc8inx 4642 11 Primer Primer NNP cord-010092-uftc8inx 4642 12 ) ) -RRB- cord-010092-uftc8inx 4642 13 , , , cord-010092-uftc8inx 4642 14 SSO SSO NNP cord-010092-uftc8inx 4642 15 ( ( -LRB- cord-010092-uftc8inx 4642 16 Sequence sequence NN cord-010092-uftc8inx 4642 17 Specific Specific NNP cord-010092-uftc8inx 4642 18 Oligonucleotide Oligonucleotide NNP cord-010092-uftc8inx 4642 19 ) ) -RRB- cord-010092-uftc8inx 4642 20 , , , cord-010092-uftc8inx 4642 21 SBT SBT NNP cord-010092-uftc8inx 4642 22 ( ( -LRB- cord-010092-uftc8inx 4642 23 Sequence sequence NN cord-010092-uftc8inx 4642 24 Based Based NNP cord-010092-uftc8inx 4642 25 Typing Typing NNP cord-010092-uftc8inx 4642 26 ) ) -RRB- cord-010092-uftc8inx 4642 27 and and CC cord-010092-uftc8inx 4642 28 either either CC cord-010092-uftc8inx 4642 29 SSP+SSO ssp+sso JJ cord-010092-uftc8inx 4642 30 or or CC cord-010092-uftc8inx 4642 31 SSP+SBT ssp+sbt JJ cord-010092-uftc8inx 4642 32 were be VBD cord-010092-uftc8inx 4642 33 used use VBN cord-010092-uftc8inx 4642 34 , , , cord-010092-uftc8inx 4642 35 the the DT cord-010092-uftc8inx 4642 36 methods method NNS cord-010092-uftc8inx 4642 37 of of IN cord-010092-uftc8inx 4642 38 HLA HLA NNP cord-010092-uftc8inx 4642 39 antibody antibody NN cord-010092-uftc8inx 4642 40 including include VBG cord-010092-uftc8inx 4642 41 ELISA ELISA NNP cord-010092-uftc8inx 4642 42 , , , cord-010092-uftc8inx 4642 43 flow flow NN cord-010092-uftc8inx 4642 44 cytometry cytometry NN cord-010092-uftc8inx 4642 45 and and CC cord-010092-uftc8inx 4642 46 Luminex Luminex NNP cord-010092-uftc8inx 4642 47 were be VBD cord-010092-uftc8inx 4642 48 used use VBN cord-010092-uftc8inx 4642 49 and and CC cord-010092-uftc8inx 4642 50 the the DT cord-010092-uftc8inx 4642 51 methods method NNS cord-010092-uftc8inx 4642 52 of of IN cord-010092-uftc8inx 4642 53 Platelet platelet NN cord-010092-uftc8inx 4642 54 antibody antibody NN cord-010092-uftc8inx 4642 55 including include VBG cord-010092-uftc8inx 4642 56 SPRCA SPRCA NNP cord-010092-uftc8inx 4642 57 and and CC cord-010092-uftc8inx 4642 58 Elisa Elisa NNP cord-010092-uftc8inx 4642 59 were be VBD cord-010092-uftc8inx 4642 60 used use VBN cord-010092-uftc8inx 4642 61 . . . cord-010092-uftc8inx 4643 1 There there EX cord-010092-uftc8inx 4643 2 are be VBP cord-010092-uftc8inx 4643 3 four four CD cord-010092-uftc8inx 4643 4 shipments shipment NNS cord-010092-uftc8inx 4643 5 of of IN cord-010092-uftc8inx 4643 6 exercise exercise NN cord-010092-uftc8inx 4643 7 materials material NNS cord-010092-uftc8inx 4643 8 in in IN cord-010092-uftc8inx 4643 9 two two CD cord-010092-uftc8inx 4643 10 years year NNS cord-010092-uftc8inx 4643 11 and and CC cord-010092-uftc8inx 4643 12 each each DT cord-010092-uftc8inx 4643 13 shipment shipment NN cord-010092-uftc8inx 4643 14 include include VBP cord-010092-uftc8inx 4643 15 two two CD cord-010092-uftc8inx 4643 16 positive positive JJ cord-010092-uftc8inx 4643 17 and and CC cord-010092-uftc8inx 4643 18 one one CD cord-010092-uftc8inx 4643 19 negative negative JJ cord-010092-uftc8inx 4643 20 samples sample NNS cord-010092-uftc8inx 4643 21 for for IN cord-010092-uftc8inx 4643 22 antibody antibody NN cord-010092-uftc8inx 4643 23 detection detection NN cord-010092-uftc8inx 4643 24 , , , cord-010092-uftc8inx 4643 25 two two CD cord-010092-uftc8inx 4643 26 each each DT cord-010092-uftc8inx 4643 27 of of IN cord-010092-uftc8inx 4643 28 whole whole JJ cord-010092-uftc8inx 4643 29 blood blood NN cord-010092-uftc8inx 4643 30 and and CC cord-010092-uftc8inx 4643 31 serum serum NN cord-010092-uftc8inx 4643 32 for for IN cord-010092-uftc8inx 4643 33 cytotoxicity cytotoxicity NN cord-010092-uftc8inx 4643 34 of of IN cord-010092-uftc8inx 4643 35 T T NNP cord-010092-uftc8inx 4643 36 and and CC cord-010092-uftc8inx 4643 37 B B NNP cord-010092-uftc8inx 4643 38 cell cell NN cord-010092-uftc8inx 4643 39 and and CC cord-010092-uftc8inx 4643 40 three three CD cord-010092-uftc8inx 4643 41 whole whole JJ cord-010092-uftc8inx 4643 42 blood blood NN cord-010092-uftc8inx 4643 43 for for IN cord-010092-uftc8inx 4643 44 HLA HLA NNP cord-010092-uftc8inx 4643 45 genotyping genotyping NN cord-010092-uftc8inx 4643 46 . . . cord-010092-uftc8inx 4644 1 Aims aim VBZ cord-010092-uftc8inx 4644 2 : : : cord-010092-uftc8inx 4645 1 This this DT cord-010092-uftc8inx 4645 2 study study NN cord-010092-uftc8inx 4645 3 aims aim VBZ cord-010092-uftc8inx 4645 4 to to TO cord-010092-uftc8inx 4645 5 survey survey VB cord-010092-uftc8inx 4645 6 transfusion transfusion NN cord-010092-uftc8inx 4645 7 related relate VBN cord-010092-uftc8inx 4645 8 laboratory laboratory NN cord-010092-uftc8inx 4645 9 tests test NNS cord-010092-uftc8inx 4645 10 for for IN cord-010092-uftc8inx 4645 11 the the DT cord-010092-uftc8inx 4645 12 quality quality NN cord-010092-uftc8inx 4645 13 improvement improvement NN cord-010092-uftc8inx 4645 14 of of IN cord-010092-uftc8inx 4645 15 hospital hospital NN cord-010092-uftc8inx 4645 16 's 's POS cord-010092-uftc8inx 4645 17 blood blood NN cord-010092-uftc8inx 4645 18 bank bank NN cord-010092-uftc8inx 4645 19 management management NN cord-010092-uftc8inx 4645 20 . . . cord-010092-uftc8inx 4646 1 Methods method NNS cord-010092-uftc8inx 4646 2 : : : cord-010092-uftc8inx 4646 3 We -PRON- PRP cord-010092-uftc8inx 4646 4 analyzed analyze VBD cord-010092-uftc8inx 4646 5 survey survey NN cord-010092-uftc8inx 4646 6 results result NNS cord-010092-uftc8inx 4646 7 of of IN cord-010092-uftc8inx 4646 8 11 11 CD cord-010092-uftc8inx 4646 9 kinds kind NNS cord-010092-uftc8inx 4646 10 of of IN cord-010092-uftc8inx 4646 11 routine routine JJ cord-010092-uftc8inx 4646 12 work work NN cord-010092-uftc8inx 4646 13 categories category NNS cord-010092-uftc8inx 4646 14 of of IN cord-010092-uftc8inx 4646 15 841 841 CD cord-010092-uftc8inx 4646 16 blood blood NN cord-010092-uftc8inx 4646 17 banks bank NNS cord-010092-uftc8inx 4646 18 that that WDT cord-010092-uftc8inx 4646 19 were be VBD cord-010092-uftc8inx 4646 20 registered register VBN cord-010092-uftc8inx 4646 21 on on IN cord-010092-uftc8inx 4646 22 Korean korean JJ cord-010092-uftc8inx 4646 23 association association NN cord-010092-uftc8inx 4646 24 of of IN cord-010092-uftc8inx 4646 25 external external NNP cord-010092-uftc8inx 4646 26 quality quality NNP cord-010092-uftc8inx 4646 27 assessment assessment NN cord-010092-uftc8inx 4646 28 service service NN cord-010092-uftc8inx 4646 29 . . . cord-010092-uftc8inx 4647 1 Blood blood NN cord-010092-uftc8inx 4647 2 bank bank NN cord-010092-uftc8inx 4647 3 worker worker NN cord-010092-uftc8inx 4647 4 voluntarily voluntarily RB cord-010092-uftc8inx 4647 5 replied reply VBD cord-010092-uftc8inx 4647 6 this this DT cord-010092-uftc8inx 4647 7 electronic electronic JJ cord-010092-uftc8inx 4647 8 survey survey NN cord-010092-uftc8inx 4647 9 . . . cord-010092-uftc8inx 4648 1 The the DT cord-010092-uftc8inx 4648 2 11 11 CD cord-010092-uftc8inx 4648 3 categories category NNS cord-010092-uftc8inx 4648 4 were be VBD cord-010092-uftc8inx 4648 5 as as IN cord-010092-uftc8inx 4648 6 follows follow VBZ cord-010092-uftc8inx 4648 7 : : : cord-010092-uftc8inx 4648 8 1 1 LS cord-010092-uftc8inx 4648 9 . . . cord-010092-uftc8inx 4649 1 Characteristics characteristic NNS cord-010092-uftc8inx 4649 2 of of IN cord-010092-uftc8inx 4649 3 institution institution NN cord-010092-uftc8inx 4649 4 2 2 CD cord-010092-uftc8inx 4649 5 . . . cord-010092-uftc8inx 4650 1 The the DT cord-010092-uftc8inx 4650 2 equipment equipment NN cord-010092-uftc8inx 4650 3 of of IN cord-010092-uftc8inx 4650 4 blood blood NN cord-010092-uftc8inx 4650 5 bank bank NN cord-010092-uftc8inx 4650 6 3 3 CD cord-010092-uftc8inx 4650 7 . . . cord-010092-uftc8inx 4651 1 The the DT cord-010092-uftc8inx 4651 2 kinds kind NNS cord-010092-uftc8inx 4651 3 of of IN cord-010092-uftc8inx 4651 4 tube tube NN cord-010092-uftc8inx 4651 5 in in IN cord-010092-uftc8inx 4651 6 blood blood NN cord-010092-uftc8inx 4651 7 bank bank NN cord-010092-uftc8inx 4651 8 4 4 CD cord-010092-uftc8inx 4651 9 . . . cord-010092-uftc8inx 4652 1 The the DT cord-010092-uftc8inx 4652 2 present present JJ cord-010092-uftc8inx 4652 3 kinds kind NNS cord-010092-uftc8inx 4652 4 of of IN cord-010092-uftc8inx 4652 5 blood blood NN cord-010092-uftc8inx 4652 6 bank bank NN cord-010092-uftc8inx 4652 7 tests test NNS cord-010092-uftc8inx 4652 8 5 5 CD cord-010092-uftc8inx 4652 9 . . . cord-010092-uftc8inx 4653 1 ABO ABO NNP cord-010092-uftc8inx 4653 2 and and CC cord-010092-uftc8inx 4653 3 Rh Rh NNP cord-010092-uftc8inx 4653 4 type type NN cord-010092-uftc8inx 4653 5 tests test VBZ cord-010092-uftc8inx 4653 6 6 6 CD cord-010092-uftc8inx 4653 7 . . . cord-010092-uftc8inx 4654 1 The the DT cord-010092-uftc8inx 4654 2 cross cross NN cord-010092-uftc8inx 4654 3 - - JJ cord-010092-uftc8inx 4654 4 match match JJ cord-010092-uftc8inx 4654 5 tests test NNS cord-010092-uftc8inx 4654 6 7 7 CD cord-010092-uftc8inx 4654 7 . . . cord-010092-uftc8inx 4655 1 The the DT cord-010092-uftc8inx 4655 2 irregular irregular JJ cord-010092-uftc8inx 4655 3 antibody antibody NN cord-010092-uftc8inx 4655 4 tests test NNS cord-010092-uftc8inx 4655 5 8 8 CD cord-010092-uftc8inx 4655 6 . . . cord-010092-uftc8inx 4656 1 Hemovigilance hemovigilance NN cord-010092-uftc8inx 4656 2 system system NN cord-010092-uftc8inx 4656 3 9 9 CD cord-010092-uftc8inx 4656 4 . . . cord-010092-uftc8inx 4657 1 Other other JJ cord-010092-uftc8inx 4657 2 blood blood NN cord-010092-uftc8inx 4657 3 bank bank NN cord-010092-uftc8inx 4657 4 tests test VBZ cord-010092-uftc8inx 4657 5 10 10 CD cord-010092-uftc8inx 4657 6 . . . cord-010092-uftc8inx 4658 1 Massive massive JJ cord-010092-uftc8inx 4658 2 transfusion transfusion NN cord-010092-uftc8inx 4658 3 protocol protocol NN cord-010092-uftc8inx 4658 4 11 11 CD cord-010092-uftc8inx 4658 5 . . . cord-010092-uftc8inx 4659 1 Quality quality NN cord-010092-uftc8inx 4659 2 control control NN cord-010092-uftc8inx 4659 3 issues issue NNS cord-010092-uftc8inx 4659 4 We -PRON- PRP cord-010092-uftc8inx 4659 5 analyzed analyze VBD cord-010092-uftc8inx 4659 6 and and CC cord-010092-uftc8inx 4659 7 compared compare VBN cord-010092-uftc8inx 4659 8 each each DT cord-010092-uftc8inx 4659 9 category category NN cord-010092-uftc8inx 4659 10 data datum NNS cord-010092-uftc8inx 4659 11 according accord VBG cord-010092-uftc8inx 4659 12 to to IN cord-010092-uftc8inx 4659 13 considering consider VBG cord-010092-uftc8inx 4659 14 characteristics characteristic NNS cord-010092-uftc8inx 4659 15 of of IN cord-010092-uftc8inx 4659 16 hospitals hospital NNS cord-010092-uftc8inx 4659 17 . . . cord-010092-uftc8inx 4660 1 Results result NNS cord-010092-uftc8inx 4660 2 : : : cord-010092-uftc8inx 4661 1 There there EX cord-010092-uftc8inx 4661 2 were be VBD cord-010092-uftc8inx 4661 3 consensus consensus NN cord-010092-uftc8inx 4661 4 and and CC cord-010092-uftc8inx 4661 5 some some DT cord-010092-uftc8inx 4661 6 differences difference NNS cord-010092-uftc8inx 4661 7 of of IN cord-010092-uftc8inx 4661 8 current current JJ cord-010092-uftc8inx 4661 9 blood blood NN cord-010092-uftc8inx 4661 10 bank bank NN cord-010092-uftc8inx 4661 11 tests test NNS cord-010092-uftc8inx 4661 12 . . . cord-010092-uftc8inx 4662 1 We -PRON- PRP cord-010092-uftc8inx 4662 2 presents present VBZ cord-010092-uftc8inx 4662 3 the the DT cord-010092-uftc8inx 4662 4 result result NN cord-010092-uftc8inx 4662 5 of of IN cord-010092-uftc8inx 4662 6 a a DT cord-010092-uftc8inx 4662 7 pilot pilot NN cord-010092-uftc8inx 4662 8 survey survey NN cord-010092-uftc8inx 4662 9 . . . cord-010092-uftc8inx 4663 1 Especially especially RB cord-010092-uftc8inx 4663 2 the the DT cord-010092-uftc8inx 4663 3 cross cross NN cord-010092-uftc8inx 4663 4 - - JJ cord-010092-uftc8inx 4663 5 match match JJ cord-010092-uftc8inx 4663 6 tests test NNS cord-010092-uftc8inx 4663 7 were be VBD cord-010092-uftc8inx 4663 8 divided divide VBN cord-010092-uftc8inx 4663 9 by by IN cord-010092-uftc8inx 4663 10 saline saline NN cord-010092-uftc8inx 4663 11 phase phase NN cord-010092-uftc8inx 4663 12 method method NN cord-010092-uftc8inx 4663 13 added add VBN cord-010092-uftc8inx 4663 14 with with IN cord-010092-uftc8inx 4663 15 irregular irregular JJ cord-010092-uftc8inx 4663 16 antibody antibody NN cord-010092-uftc8inx 4663 17 tests test NNS cord-010092-uftc8inx 4663 18 or or CC cord-010092-uftc8inx 4663 19 completion completion NN cord-010092-uftc8inx 4663 20 of of IN cord-010092-uftc8inx 4663 21 3rd 3rd JJ cord-010092-uftc8inx 4663 22 step step NN cord-010092-uftc8inx 4663 23 anti anti JJ cord-010092-uftc8inx 4663 24 - - JJ cord-010092-uftc8inx 4663 25 human human JJ cord-010092-uftc8inx 4663 26 globulin globulin NN cord-010092-uftc8inx 4663 27 phase phase NN cord-010092-uftc8inx 4663 28 according accord VBG cord-010092-uftc8inx 4663 29 to to IN cord-010092-uftc8inx 4663 30 institutional institutional JJ cord-010092-uftc8inx 4663 31 environment environment NN cord-010092-uftc8inx 4663 32 . . . cord-010092-uftc8inx 4664 1 Automated automate VBN cord-010092-uftc8inx 4664 2 typing typing NN cord-010092-uftc8inx 4664 3 machines machine NNS cord-010092-uftc8inx 4664 4 or or CC cord-010092-uftc8inx 4664 5 automated automate VBN cord-010092-uftc8inx 4664 6 irregular irregular JJ cord-010092-uftc8inx 4664 7 antibody antibody NN cord-010092-uftc8inx 4664 8 test test NN cord-010092-uftc8inx 4664 9 devices device NNS cord-010092-uftc8inx 4664 10 were be VBD cord-010092-uftc8inx 4664 11 more more RBR cord-010092-uftc8inx 4664 12 increased increase VBN cord-010092-uftc8inx 4664 13 in in IN cord-010092-uftc8inx 4664 14 large large JJ cord-010092-uftc8inx 4664 15 - - HYPH cord-010092-uftc8inx 4664 16 scale scale NN cord-010092-uftc8inx 4664 17 hospitals hospital NNS cord-010092-uftc8inx 4664 18 than than IN cord-010092-uftc8inx 4664 19 small small JJ cord-010092-uftc8inx 4664 20 - - HYPH cord-010092-uftc8inx 4664 21 scale scale NN cord-010092-uftc8inx 4664 22 hospitals hospital NNS cord-010092-uftc8inx 4664 23 . . . cord-010092-uftc8inx 4665 1 Different different JJ cord-010092-uftc8inx 4665 2 kinds kind NNS cord-010092-uftc8inx 4665 3 of of IN cord-010092-uftc8inx 4665 4 tubes tube NNS cord-010092-uftc8inx 4665 5 were be VBD cord-010092-uftc8inx 4665 6 used use VBN cord-010092-uftc8inx 4665 7 such such JJ cord-010092-uftc8inx 4665 8 as as IN cord-010092-uftc8inx 4665 9 EDTA edta NN cord-010092-uftc8inx 4665 10 tube tube NN cord-010092-uftc8inx 4665 11 for for IN cord-010092-uftc8inx 4665 12 ABO ABO NNP cord-010092-uftc8inx 4665 13 and and CC cord-010092-uftc8inx 4665 14 Rh Rh NNP cord-010092-uftc8inx 4665 15 typing typing NN cord-010092-uftc8inx 4665 16 , , , cord-010092-uftc8inx 4665 17 plain plain JJ cord-010092-uftc8inx 4665 18 tube tube NN cord-010092-uftc8inx 4665 19 for for IN cord-010092-uftc8inx 4665 20 cross cross JJ cord-010092-uftc8inx 4665 21 - - JJ cord-010092-uftc8inx 4665 22 match match JJ cord-010092-uftc8inx 4665 23 test test NN cord-010092-uftc8inx 4665 24 . . . cord-010092-uftc8inx 4666 1 The the DT cord-010092-uftc8inx 4666 2 retention retention NN cord-010092-uftc8inx 4666 3 segments segment NNS cord-010092-uftc8inx 4666 4 of of IN cord-010092-uftc8inx 4666 5 RBC RBC NNP cord-010092-uftc8inx 4666 6 were be VBD cord-010092-uftc8inx 4666 7 reserved reserve VBN cord-010092-uftc8inx 4666 8 for for IN cord-010092-uftc8inx 4666 9 minimum minimum JJ cord-010092-uftc8inx 4666 10 7 7 CD cord-010092-uftc8inx 4666 11 days day NNS cord-010092-uftc8inx 4666 12 . . . cord-010092-uftc8inx 4667 1 Most Most JJS cord-010092-uftc8inx 4667 2 blood blood NN cord-010092-uftc8inx 4667 3 bank bank NN cord-010092-uftc8inx 4667 4 were be VBD cord-010092-uftc8inx 4667 5 registered register VBN cord-010092-uftc8inx 4667 6 and and CC cord-010092-uftc8inx 4667 7 regularly regularly RB cord-010092-uftc8inx 4667 8 listed list VBN cord-010092-uftc8inx 4667 9 up up RP cord-010092-uftc8inx 4667 10 transfusion transfusion NN cord-010092-uftc8inx 4667 11 events event NNS cord-010092-uftc8inx 4667 12 to to IN cord-010092-uftc8inx 4667 13 Korean korean JJ cord-010092-uftc8inx 4667 14 hemovigilance hemovigilance NN cord-010092-uftc8inx 4667 15 system system NN cord-010092-uftc8inx 4667 16 for for IN cord-010092-uftc8inx 4667 17 safety safety NN cord-010092-uftc8inx 4667 18 transfusion transfusion NN cord-010092-uftc8inx 4667 19 . . . cord-010092-uftc8inx 4668 1 Also also RB cord-010092-uftc8inx 4668 2 , , , cord-010092-uftc8inx 4668 3 a a DT cord-010092-uftc8inx 4668 4 lot lot NN cord-010092-uftc8inx 4668 5 of of IN cord-010092-uftc8inx 4668 6 institution institution NN cord-010092-uftc8inx 4668 7 have have VBP cord-010092-uftc8inx 4668 8 none none NN cord-010092-uftc8inx 4668 9 or or CC cord-010092-uftc8inx 4668 10 underdeveloped underdeveloped JJ cord-010092-uftc8inx 4668 11 massive massive JJ cord-010092-uftc8inx 4668 12 transfusion transfusion NN cord-010092-uftc8inx 4668 13 protocol protocol NN cord-010092-uftc8inx 4668 14 . . . cord-010092-uftc8inx 4669 1 More more RBR cord-010092-uftc8inx 4669 2 specific specific JJ cord-010092-uftc8inx 4669 3 survey survey NN cord-010092-uftc8inx 4669 4 results result NNS cord-010092-uftc8inx 4669 5 will will MD cord-010092-uftc8inx 4669 6 be be VB cord-010092-uftc8inx 4669 7 analyzed analyze VBN cord-010092-uftc8inx 4669 8 in in IN cord-010092-uftc8inx 4669 9 further further JJ cord-010092-uftc8inx 4669 10 poster poster NN cord-010092-uftc8inx 4669 11 presentation presentation NN cord-010092-uftc8inx 4669 12 . . . cord-010092-uftc8inx 4670 1 Summary Summary NNP cord-010092-uftc8inx 4670 2 / / SYM cord-010092-uftc8inx 4670 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 4670 4 : : : cord-010092-uftc8inx 4671 1 This this DT cord-010092-uftc8inx 4671 2 survey survey NN cord-010092-uftc8inx 4671 3 will will MD cord-010092-uftc8inx 4671 4 show show VB cord-010092-uftc8inx 4671 5 the the DT cord-010092-uftc8inx 4671 6 current current JJ cord-010092-uftc8inx 4671 7 status status NN cord-010092-uftc8inx 4671 8 of of IN cord-010092-uftc8inx 4671 9 transfusion transfusion NN cord-010092-uftc8inx 4671 10 related relate VBN cord-010092-uftc8inx 4671 11 blood blood NN cord-010092-uftc8inx 4671 12 bank bank NN cord-010092-uftc8inx 4671 13 test test NN cord-010092-uftc8inx 4671 14 . . . cord-010092-uftc8inx 4672 1 This this DT cord-010092-uftc8inx 4672 2 institutional institutional JJ cord-010092-uftc8inx 4672 3 blood blood NN cord-010092-uftc8inx 4672 4 bank bank NN cord-010092-uftc8inx 4672 5 comparison comparison NN cord-010092-uftc8inx 4672 6 will will MD cord-010092-uftc8inx 4672 7 be be VB cord-010092-uftc8inx 4672 8 helpful helpful JJ cord-010092-uftc8inx 4672 9 to to TO cord-010092-uftc8inx 4672 10 assess assess VB cord-010092-uftc8inx 4672 11 the the DT cord-010092-uftc8inx 4672 12 currency currency NN cord-010092-uftc8inx 4672 13 of of IN cord-010092-uftc8inx 4672 14 individual individual JJ cord-010092-uftc8inx 4672 15 blood blood NN cord-010092-uftc8inx 4672 16 bank bank NN cord-010092-uftc8inx 4672 17 environments environment NNS cord-010092-uftc8inx 4672 18 . . . cord-010092-uftc8inx 4673 1 Abstract Abstract NNP cord-010092-uftc8inx 4673 2 withdrawn withdraw VBN cord-010092-uftc8inx 4673 3 . . . cord-010092-uftc8inx 4674 1 Background background NN cord-010092-uftc8inx 4674 2 : : : cord-010092-uftc8inx 4675 1 We -PRON- PRP cord-010092-uftc8inx 4675 2 know know VBP cord-010092-uftc8inx 4675 3 that that IN cord-010092-uftc8inx 4675 4 quality quality NN cord-010092-uftc8inx 4675 5 management management NN cord-010092-uftc8inx 4675 6 is be VBZ cord-010092-uftc8inx 4675 7 a a DT cord-010092-uftc8inx 4675 8 continuous continuous JJ cord-010092-uftc8inx 4675 9 process process NN cord-010092-uftc8inx 4675 10 , , , cord-010092-uftc8inx 4675 11 involving involve VBG cord-010092-uftc8inx 4675 12 implementation implementation NN cord-010092-uftc8inx 4675 13 , , , cord-010092-uftc8inx 4675 14 maintenance maintenance NN cord-010092-uftc8inx 4675 15 and and CC cord-010092-uftc8inx 4675 16 improvement improvement NN cord-010092-uftc8inx 4675 17 . . . cord-010092-uftc8inx 4676 1 Aims aim VBZ cord-010092-uftc8inx 4676 2 : : : cord-010092-uftc8inx 4677 1 Our -PRON- PRP$ cord-010092-uftc8inx 4677 2 purpose purpose NN cord-010092-uftc8inx 4677 3 is be VBZ cord-010092-uftc8inx 4677 4 to to TO cord-010092-uftc8inx 4677 5 show show VB cord-010092-uftc8inx 4677 6 our -PRON- PRP$ cord-010092-uftc8inx 4677 7 experience experience NN cord-010092-uftc8inx 4677 8 in in IN cord-010092-uftc8inx 4677 9 implementing implement VBG cord-010092-uftc8inx 4677 10 the the DT cord-010092-uftc8inx 4677 11 quality quality NN cord-010092-uftc8inx 4677 12 management management NN cord-010092-uftc8inx 4677 13 system system NN cord-010092-uftc8inx 4677 14 in in IN cord-010092-uftc8inx 4677 15 the the DT cord-010092-uftc8inx 4677 16 whole whole JJ cord-010092-uftc8inx 4677 17 institution institution NN cord-010092-uftc8inx 4677 18 and and CC cord-010092-uftc8inx 4677 19 our -PRON- PRP$ cord-010092-uftc8inx 4677 20 first first JJ cord-010092-uftc8inx 4677 21 steps step NNS cord-010092-uftc8inx 4677 22 in in IN cord-010092-uftc8inx 4677 23 achieving achieve VBG cord-010092-uftc8inx 4677 24 the the DT cord-010092-uftc8inx 4677 25 JACIE JACIE NNP cord-010092-uftc8inx 4677 26 accreditation accreditation NN cord-010092-uftc8inx 4677 27 in in IN cord-010092-uftc8inx 4677 28 the the DT cord-010092-uftc8inx 4677 29 Stem Stem NNP cord-010092-uftc8inx 4677 30 Cell Cell NNP cord-010092-uftc8inx 4677 31 Collection Collection NNP cord-010092-uftc8inx 4677 32 Facility Facility NNP cord-010092-uftc8inx 4677 33 in in IN cord-010092-uftc8inx 4677 34 order order NN cord-010092-uftc8inx 4677 35 to to TO cord-010092-uftc8inx 4677 36 provide provide VB cord-010092-uftc8inx 4677 37 our -PRON- PRP$ cord-010092-uftc8inx 4677 38 patients patient NNS cord-010092-uftc8inx 4677 39 and and CC cord-010092-uftc8inx 4677 40 donors donor NNS cord-010092-uftc8inx 4677 41 the the DT cord-010092-uftc8inx 4677 42 best good JJS cord-010092-uftc8inx 4677 43 possible possible JJ cord-010092-uftc8inx 4677 44 care care NN cord-010092-uftc8inx 4677 45 . . . cord-010092-uftc8inx 4678 1 Methods method NNS cord-010092-uftc8inx 4678 2 : : : cord-010092-uftc8inx 4679 1 The the DT cord-010092-uftc8inx 4679 2 Institute Institute NNP cord-010092-uftc8inx 4679 3 for for IN cord-010092-uftc8inx 4679 4 Transfusion Transfusion NNP cord-010092-uftc8inx 4679 5 Medicine Medicine NNP cord-010092-uftc8inx 4679 6 of of IN cord-010092-uftc8inx 4679 7 the the DT cord-010092-uftc8inx 4679 8 Republic Republic NNP cord-010092-uftc8inx 4679 9 of of IN cord-010092-uftc8inx 4679 10 Macedonia Macedonia NNP cord-010092-uftc8inx 4679 11 ( ( -LRB- cord-010092-uftc8inx 4679 12 ITM ITM NNP cord-010092-uftc8inx 4679 13 ) ) -RRB- cord-010092-uftc8inx 4679 14 is be VBZ cord-010092-uftc8inx 4679 15 the the DT cord-010092-uftc8inx 4679 16 main main JJ cord-010092-uftc8inx 4679 17 institution institution NN cord-010092-uftc8inx 4679 18 in in IN cord-010092-uftc8inx 4679 19 charge charge NN cord-010092-uftc8inx 4679 20 of of IN cord-010092-uftc8inx 4679 21 Blood Blood NNP cord-010092-uftc8inx 4679 22 Transfusion Transfusion NNP cord-010092-uftc8inx 4679 23 Service Service NNP cord-010092-uftc8inx 4679 24 ( ( -LRB- cord-010092-uftc8inx 4679 25 BTS BTS NNP cord-010092-uftc8inx 4679 26 ) ) -RRB- cord-010092-uftc8inx 4679 27 in in IN cord-010092-uftc8inx 4679 28 the the DT cord-010092-uftc8inx 4679 29 whole whole JJ cord-010092-uftc8inx 4679 30 country country NN cord-010092-uftc8inx 4679 31 , , , cord-010092-uftc8inx 4679 32 which which WDT cord-010092-uftc8inx 4679 33 is be VBZ cord-010092-uftc8inx 4679 34 the the DT cord-010092-uftc8inx 4679 35 national national JJ cord-010092-uftc8inx 4679 36 unified unified JJ cord-010092-uftc8inx 4679 37 system system NN cord-010092-uftc8inx 4679 38 . . . cord-010092-uftc8inx 4680 1 The the DT cord-010092-uftc8inx 4680 2 Stem Stem NNP cord-010092-uftc8inx 4680 3 Cell Cell NNP cord-010092-uftc8inx 4680 4 Collection Collection NNP cord-010092-uftc8inx 4680 5 Facility Facility NNP cord-010092-uftc8inx 4680 6 is be VBZ cord-010092-uftc8inx 4680 7 a a DT cord-010092-uftc8inx 4680 8 part part NN cord-010092-uftc8inx 4680 9 of of IN cord-010092-uftc8inx 4680 10 the the DT cord-010092-uftc8inx 4680 11 ITM ITM NNP cord-010092-uftc8inx 4680 12 . . . cord-010092-uftc8inx 4681 1 This this DT cord-010092-uftc8inx 4681 2 Facility Facility NNP cord-010092-uftc8inx 4681 3 is be VBZ cord-010092-uftc8inx 4681 4 operational operational JJ cord-010092-uftc8inx 4681 5 since since IN cord-010092-uftc8inx 4681 6 2001 2001 CD cord-010092-uftc8inx 4681 7 year year NN cord-010092-uftc8inx 4681 8 with with IN cord-010092-uftc8inx 4681 9 844 844 CD cord-010092-uftc8inx 4681 10 collections collection NNS cord-010092-uftc8inx 4681 11 of of IN cord-010092-uftc8inx 4681 12 stem stem NN cord-010092-uftc8inx 4681 13 cells cell NNS cord-010092-uftc8inx 4681 14 ( ( -LRB- cord-010092-uftc8inx 4681 15 686 686 CD cord-010092-uftc8inx 4681 16 in in IN cord-010092-uftc8inx 4681 17 patients patient NNS cord-010092-uftc8inx 4681 18 and and CC cord-010092-uftc8inx 4681 19 159 159 CD cord-010092-uftc8inx 4681 20 collections collection NNS cord-010092-uftc8inx 4681 21 in in IN cord-010092-uftc8inx 4681 22 sibling sibling NN cord-010092-uftc8inx 4681 23 donors donor NNS cord-010092-uftc8inx 4681 24 ) ) -RRB- cord-010092-uftc8inx 4681 25 till till IN cord-010092-uftc8inx 4681 26 now now RB cord-010092-uftc8inx 4681 27 . . . cord-010092-uftc8inx 4682 1 We -PRON- PRP cord-010092-uftc8inx 4682 2 are be VBP cord-010092-uftc8inx 4682 3 obtaining obtain VBG cord-010092-uftc8inx 4682 4 the the DT cord-010092-uftc8inx 4682 5 implementation implementation NN cord-010092-uftc8inx 4682 6 and and CC cord-010092-uftc8inx 4682 7 maintenance maintenance NN cord-010092-uftc8inx 4682 8 of of IN cord-010092-uftc8inx 4682 9 QMS QMS NNP cord-010092-uftc8inx 4682 10 through through IN cord-010092-uftc8inx 4682 11 the the DT cord-010092-uftc8inx 4682 12 establishing establishing NN cord-010092-uftc8inx 4682 13 of of IN cord-010092-uftc8inx 4682 14 the the DT cord-010092-uftc8inx 4682 15 ISO iso NN cord-010092-uftc8inx 4682 16 standardization standardization NN cord-010092-uftc8inx 4682 17 for for IN cord-010092-uftc8inx 4682 18 the the DT cord-010092-uftc8inx 4682 19 whole whole JJ cord-010092-uftc8inx 4682 20 institution institution NN cord-010092-uftc8inx 4682 21 ( ( -LRB- cord-010092-uftc8inx 4682 22 ITM ITM NNP cord-010092-uftc8inx 4682 23 ) ) -RRB- cord-010092-uftc8inx 4682 24 , , , cord-010092-uftc8inx 4682 25 as as RB cord-010092-uftc8inx 4682 26 well well RB cord-010092-uftc8inx 4682 27 as as IN cord-010092-uftc8inx 4682 28 of of IN cord-010092-uftc8inx 4682 29 implementing implement VBG cord-010092-uftc8inx 4682 30 JACIE JACIE NNP cord-010092-uftc8inx 4682 31 standards standard NNS cord-010092-uftc8inx 4682 32 in in IN cord-010092-uftc8inx 4682 33 the the DT cord-010092-uftc8inx 4682 34 Stem Stem NNP cord-010092-uftc8inx 4682 35 Cell Cell NNP cord-010092-uftc8inx 4682 36 Collection Collection NNP cord-010092-uftc8inx 4682 37 Facility Facility NNP cord-010092-uftc8inx 4682 38 . . . cord-010092-uftc8inx 4683 1 The the DT cord-010092-uftc8inx 4683 2 two two CD cord-010092-uftc8inx 4683 3 of of IN cord-010092-uftc8inx 4683 4 our -PRON- PRP$ cord-010092-uftc8inx 4683 5 colleagues colleague NNS cord-010092-uftc8inx 4683 6 became become VBD cord-010092-uftc8inx 4683 7 the the DT cord-010092-uftc8inx 4683 8 JACIE JACIE NNP cord-010092-uftc8inx 4683 9 Inspectors Inspectors NNPS cord-010092-uftc8inx 4683 10 and and CC cord-010092-uftc8inx 4683 11 the the DT cord-010092-uftc8inx 4683 12 standard standard JJ cord-010092-uftc8inx 4683 13 operating operating NN cord-010092-uftc8inx 4683 14 procedures procedure NNS cord-010092-uftc8inx 4683 15 ( ( -LRB- cord-010092-uftc8inx 4683 16 SOPs sop NNS cord-010092-uftc8inx 4683 17 ) ) -RRB- cord-010092-uftc8inx 4683 18 were be VBD cord-010092-uftc8inx 4683 19 developed develop VBN cord-010092-uftc8inx 4683 20 , , , cord-010092-uftc8inx 4683 21 followed follow VBN cord-010092-uftc8inx 4683 22 by by IN cord-010092-uftc8inx 4683 23 regular regular JJ cord-010092-uftc8inx 4683 24 meetings meeting NNS cord-010092-uftc8inx 4683 25 , , , cord-010092-uftc8inx 4683 26 trainings training NNS cord-010092-uftc8inx 4683 27 and and CC cord-010092-uftc8inx 4683 28 self self NN cord-010092-uftc8inx 4683 29 - - HYPH cord-010092-uftc8inx 4683 30 evaluation evaluation NN cord-010092-uftc8inx 4683 31 of of IN cord-010092-uftc8inx 4683 32 the the DT cord-010092-uftc8inx 4683 33 personnel personnel NNS cord-010092-uftc8inx 4683 34 . . . cord-010092-uftc8inx 4684 1 We -PRON- PRP cord-010092-uftc8inx 4684 2 asked ask VBD cord-010092-uftc8inx 4684 3 for for IN cord-010092-uftc8inx 4684 4 the the DT cord-010092-uftc8inx 4684 5 orientation orientation NN cord-010092-uftc8inx 4684 6 visit visit NN cord-010092-uftc8inx 4684 7 from from IN cord-010092-uftc8inx 4684 8 the the DT cord-010092-uftc8inx 4684 9 independent independent JJ cord-010092-uftc8inx 4684 10 JACIE JACIE NNP cord-010092-uftc8inx 4684 11 inspector inspector NN cord-010092-uftc8inx 4684 12 in in IN cord-010092-uftc8inx 4684 13 order order NN cord-010092-uftc8inx 4684 14 to to TO cord-010092-uftc8inx 4684 15 come come VB cord-010092-uftc8inx 4684 16 one one CD cord-010092-uftc8inx 4684 17 step step NN cord-010092-uftc8inx 4684 18 closer close RBR cord-010092-uftc8inx 4684 19 to to IN cord-010092-uftc8inx 4684 20 the the DT cord-010092-uftc8inx 4684 21 JACIE JACIE NNP cord-010092-uftc8inx 4684 22 accreditation accreditation NN cord-010092-uftc8inx 4684 23 and and CC cord-010092-uftc8inx 4684 24 to to TO cord-010092-uftc8inx 4684 25 improve improve VB cord-010092-uftc8inx 4684 26 our -PRON- PRP$ cord-010092-uftc8inx 4684 27 overall overall JJ cord-010092-uftc8inx 4684 28 QMS QMS NNP cord-010092-uftc8inx 4684 29 . . . cord-010092-uftc8inx 4685 1 Results result NNS cord-010092-uftc8inx 4685 2 : : : cord-010092-uftc8inx 4686 1 The the DT cord-010092-uftc8inx 4686 2 Institute Institute NNP cord-010092-uftc8inx 4686 3 for for IN cord-010092-uftc8inx 4686 4 Transfusion Transfusion NNP cord-010092-uftc8inx 4686 5 Medicine Medicine NNP cord-010092-uftc8inx 4686 6 of of IN cord-010092-uftc8inx 4686 7 RM RM NNP cord-010092-uftc8inx 4686 8 was be VBD cord-010092-uftc8inx 4686 9 a a DT cord-010092-uftc8inx 4686 10 part part NN cord-010092-uftc8inx 4686 11 of of IN cord-010092-uftc8inx 4686 12 the the DT cord-010092-uftc8inx 4686 13 IPA IPA NNP cord-010092-uftc8inx 4686 14 project project NN cord-010092-uftc8inx 4686 15 " " `` cord-010092-uftc8inx 4686 16 Strengthening strengthen VBG cord-010092-uftc8inx 4686 17 the the DT cord-010092-uftc8inx 4686 18 Blood Blood NNP cord-010092-uftc8inx 4686 19 Supply Supply NNP cord-010092-uftc8inx 4686 20 System System NNP cord-010092-uftc8inx 4686 21 " " '' cord-010092-uftc8inx 4686 22 . . . cord-010092-uftc8inx 4687 1 This this DT cord-010092-uftc8inx 4687 2 project project NN cord-010092-uftc8inx 4687 3 aimed aim VBN cord-010092-uftc8inx 4687 4 to to TO cord-010092-uftc8inx 4687 5 ultimately ultimately RB cord-010092-uftc8inx 4687 6 bring bring VB cord-010092-uftc8inx 4687 7 the the DT cord-010092-uftc8inx 4687 8 Blood Blood NNP cord-010092-uftc8inx 4687 9 Transfusion Transfusion NNP cord-010092-uftc8inx 4687 10 Service Service NNP cord-010092-uftc8inx 4687 11 to to IN cord-010092-uftc8inx 4687 12 European European NNP cord-010092-uftc8inx 4687 13 Union Union NNP cord-010092-uftc8inx 4687 14 standards standard NNS cord-010092-uftc8inx 4687 15 allowing allow VBG cord-010092-uftc8inx 4687 16 the the DT cord-010092-uftc8inx 4687 17 exchange exchange NN cord-010092-uftc8inx 4687 18 of of IN cord-010092-uftc8inx 4687 19 blood blood NN cord-010092-uftc8inx 4687 20 components component NNS cord-010092-uftc8inx 4687 21 and and CC cord-010092-uftc8inx 4687 22 all all DT cord-010092-uftc8inx 4687 23 other other JJ cord-010092-uftc8inx 4687 24 types type NNS cord-010092-uftc8inx 4687 25 of of IN cord-010092-uftc8inx 4687 26 collaboration collaboration NN cord-010092-uftc8inx 4687 27 with with IN cord-010092-uftc8inx 4687 28 other other JJ cord-010092-uftc8inx 4687 29 European European NNP cord-010092-uftc8inx 4687 30 Union Union NNP cord-010092-uftc8inx 4687 31 countries country NNS cord-010092-uftc8inx 4687 32 in in IN cord-010092-uftc8inx 4687 33 future future NN cord-010092-uftc8inx 4687 34 . . . cord-010092-uftc8inx 4688 1 The the DT cord-010092-uftc8inx 4688 2 project project NN cord-010092-uftc8inx 4688 3 put put VBD cord-010092-uftc8inx 4688 4 the the DT cord-010092-uftc8inx 4688 5 basis basis NN cord-010092-uftc8inx 4688 6 for for IN cord-010092-uftc8inx 4688 7 unification unification NN cord-010092-uftc8inx 4688 8 of of IN cord-010092-uftc8inx 4688 9 blood blood NN cord-010092-uftc8inx 4688 10 transfusion transfusion NN cord-010092-uftc8inx 4688 11 standards standard NNS cord-010092-uftc8inx 4688 12 and and CC cord-010092-uftc8inx 4688 13 operating operating NN cord-010092-uftc8inx 4688 14 procedures procedure NNS cord-010092-uftc8inx 4688 15 in in IN cord-010092-uftc8inx 4688 16 the the DT cord-010092-uftc8inx 4688 17 whole whole JJ cord-010092-uftc8inx 4688 18 country country NN cord-010092-uftc8inx 4688 19 as as RB cord-010092-uftc8inx 4688 20 well well RB cord-010092-uftc8inx 4688 21 as as IN cord-010092-uftc8inx 4688 22 set set VBN cord-010092-uftc8inx 4688 23 up up RP cord-010092-uftc8inx 4688 24 essential essential JJ cord-010092-uftc8inx 4688 25 education education NN cord-010092-uftc8inx 4688 26 of of IN cord-010092-uftc8inx 4688 27 blood blood NN cord-010092-uftc8inx 4688 28 transfusion transfusion NN cord-010092-uftc8inx 4688 29 personnel personnel NNS cord-010092-uftc8inx 4688 30 . . . cord-010092-uftc8inx 4689 1 Although although IN cord-010092-uftc8inx 4689 2 a a DT cord-010092-uftc8inx 4689 3 lot lot NN cord-010092-uftc8inx 4689 4 of of IN cord-010092-uftc8inx 4689 5 strengths strength NNS cord-010092-uftc8inx 4689 6 were be VBD cord-010092-uftc8inx 4689 7 found find VBN cord-010092-uftc8inx 4689 8 during during IN cord-010092-uftc8inx 4689 9 the the DT cord-010092-uftc8inx 4689 10 orientation orientation NN cord-010092-uftc8inx 4689 11 visit visit NN cord-010092-uftc8inx 4689 12 from from IN cord-010092-uftc8inx 4689 13 JACIE JACIE NNP cord-010092-uftc8inx 4689 14 inspector inspector NN cord-010092-uftc8inx 4689 15 , , , cord-010092-uftc8inx 4689 16 there there EX cord-010092-uftc8inx 4689 17 are be VBP cord-010092-uftc8inx 4689 18 still still RB cord-010092-uftc8inx 4689 19 a a DT cord-010092-uftc8inx 4689 20 lot lot NN cord-010092-uftc8inx 4689 21 of of IN cord-010092-uftc8inx 4689 22 areas area NNS cord-010092-uftc8inx 4689 23 for for IN cord-010092-uftc8inx 4689 24 improvement improvement NN cord-010092-uftc8inx 4689 25 . . . cord-010092-uftc8inx 4690 1 Our -PRON- PRP$ cord-010092-uftc8inx 4690 2 strengths strength NNS cord-010092-uftc8inx 4690 3 are be VBP cord-010092-uftc8inx 4690 4 motivated motivate VBN cord-010092-uftc8inx 4690 5 team team NN cord-010092-uftc8inx 4690 6 and and CC cord-010092-uftc8inx 4690 7 supportive supportive JJ cord-010092-uftc8inx 4690 8 institutional institutional JJ cord-010092-uftc8inx 4690 9 leadership leadership NN cord-010092-uftc8inx 4690 10 including include VBG cord-010092-uftc8inx 4690 11 Macedonian Macedonian NNP cord-010092-uftc8inx 4690 12 Ministry Ministry NNP cord-010092-uftc8inx 4690 13 of of IN cord-010092-uftc8inx 4690 14 Health Health NNP cord-010092-uftc8inx 4690 15 . . . cord-010092-uftc8inx 4691 1 Areas area NNS cord-010092-uftc8inx 4691 2 for for IN cord-010092-uftc8inx 4691 3 improvement improvement NN cord-010092-uftc8inx 4691 4 are be VBP cord-010092-uftc8inx 4691 5 : : : cord-010092-uftc8inx 4691 6 labeling labeling NN cord-010092-uftc8inx 4691 7 of of IN cord-010092-uftc8inx 4691 8 cellular cellular JJ cord-010092-uftc8inx 4691 9 therapy therapy NN cord-010092-uftc8inx 4691 10 products product NNS cord-010092-uftc8inx 4691 11 and and CC cord-010092-uftc8inx 4691 12 lack lack NN cord-010092-uftc8inx 4691 13 of of IN cord-010092-uftc8inx 4691 14 laboratory laboratory NN cord-010092-uftc8inx 4691 15 for for IN cord-010092-uftc8inx 4691 16 quality quality NN cord-010092-uftc8inx 4691 17 control control NN cord-010092-uftc8inx 4691 18 . . . cord-010092-uftc8inx 4692 1 There there EX cord-010092-uftc8inx 4692 2 is be VBZ cord-010092-uftc8inx 4692 3 a a DT cord-010092-uftc8inx 4692 4 national national JJ cord-010092-uftc8inx 4692 5 regulatory regulatory JJ cord-010092-uftc8inx 4692 6 framework framework NN cord-010092-uftc8inx 4692 7 in in IN cord-010092-uftc8inx 4692 8 place place NN cord-010092-uftc8inx 4692 9 and and CC cord-010092-uftc8inx 4692 10 WHO who WP cord-010092-uftc8inx 4692 11 and and CC cord-010092-uftc8inx 4692 12 World World NNP cord-010092-uftc8inx 4692 13 Bank Bank NNP cord-010092-uftc8inx 4692 14 initiatives initiative NNS cord-010092-uftc8inx 4692 15 in in IN cord-010092-uftc8inx 4692 16 Macedonia Macedonia NNP cord-010092-uftc8inx 4692 17 which which WDT cord-010092-uftc8inx 4692 18 support support VBP cord-010092-uftc8inx 4692 19 quality quality NN cord-010092-uftc8inx 4692 20 in in IN cord-010092-uftc8inx 4692 21 health health NN cord-010092-uftc8inx 4692 22 care care NN cord-010092-uftc8inx 4692 23 and and CC cord-010092-uftc8inx 4692 24 accreditation accreditation NN cord-010092-uftc8inx 4692 25 . . . cord-010092-uftc8inx 4693 1 Summary Summary NNP cord-010092-uftc8inx 4693 2 / / SYM cord-010092-uftc8inx 4693 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 4693 4 : : : cord-010092-uftc8inx 4694 1 Our -PRON- PRP$ cord-010092-uftc8inx 4694 2 institution institution NN cord-010092-uftc8inx 4694 3 has have VBZ cord-010092-uftc8inx 4694 4 in in IN cord-010092-uftc8inx 4694 5 plan plan NN cord-010092-uftc8inx 4694 6 to to TO cord-010092-uftc8inx 4694 7 implement implement VB cord-010092-uftc8inx 4694 8 ISBT ISBT NNP cord-010092-uftc8inx 4694 9 128 128 CD cord-010092-uftc8inx 4694 10 standards standard NNS cord-010092-uftc8inx 4694 11 for for IN cord-010092-uftc8inx 4694 12 labeling labeling NN cord-010092-uftc8inx 4694 13 of of IN cord-010092-uftc8inx 4694 14 cellular cellular JJ cord-010092-uftc8inx 4694 15 therapy therapy NN cord-010092-uftc8inx 4694 16 products product NNS cord-010092-uftc8inx 4694 17 and and CC cord-010092-uftc8inx 4694 18 to to TO cord-010092-uftc8inx 4694 19 establish establish VB cord-010092-uftc8inx 4694 20 a a DT cord-010092-uftc8inx 4694 21 laboratory laboratory NN cord-010092-uftc8inx 4694 22 for for IN cord-010092-uftc8inx 4694 23 quality quality NN cord-010092-uftc8inx 4694 24 control control NN cord-010092-uftc8inx 4694 25 of of IN cord-010092-uftc8inx 4694 26 cellular cellular JJ cord-010092-uftc8inx 4694 27 therapy therapy NN cord-010092-uftc8inx 4694 28 , , , cord-010092-uftc8inx 4694 29 as as RB cord-010092-uftc8inx 4694 30 well well RB cord-010092-uftc8inx 4694 31 as as IN cord-010092-uftc8inx 4694 32 to to TO cord-010092-uftc8inx 4694 33 meet meet VB cord-010092-uftc8inx 4694 34 all all PDT cord-010092-uftc8inx 4694 35 the the DT cord-010092-uftc8inx 4694 36 requirements requirement NNS cord-010092-uftc8inx 4694 37 to to TO cord-010092-uftc8inx 4694 38 become become VB cord-010092-uftc8inx 4694 39 JACIE JACIE NNP cord-010092-uftc8inx 4694 40 accredited accredited JJ cord-010092-uftc8inx 4694 41 facility facility NN cord-010092-uftc8inx 4694 42 . . . cord-010092-uftc8inx 4695 1 Working work VBG cord-010092-uftc8inx 4695 2 by by IN cord-010092-uftc8inx 4695 3 standards standard NNS cord-010092-uftc8inx 4695 4 , , , cord-010092-uftc8inx 4695 5 following follow VBG cord-010092-uftc8inx 4695 6 the the DT cord-010092-uftc8inx 4695 7 rules rule NNS cord-010092-uftc8inx 4695 8 and and CC cord-010092-uftc8inx 4695 9 regular regular JJ cord-010092-uftc8inx 4695 10 self self NN cord-010092-uftc8inx 4695 11 - - HYPH cord-010092-uftc8inx 4695 12 evaluations evaluation NNS cord-010092-uftc8inx 4695 13 will will MD cord-010092-uftc8inx 4695 14 help help VB cord-010092-uftc8inx 4695 15 us -PRON- PRP cord-010092-uftc8inx 4695 16 to to TO cord-010092-uftc8inx 4695 17 maintain maintain VB cord-010092-uftc8inx 4695 18 the the DT cord-010092-uftc8inx 4695 19 strong strong JJ cord-010092-uftc8inx 4695 20 quality quality NN cord-010092-uftc8inx 4695 21 management management NN cord-010092-uftc8inx 4695 22 system system NN cord-010092-uftc8inx 4695 23 . . . cord-010092-uftc8inx 4696 1 Every every DT cord-010092-uftc8inx 4696 2 institution institution NN cord-010092-uftc8inx 4696 3 will will MD cord-010092-uftc8inx 4696 4 benefit benefit VB cord-010092-uftc8inx 4696 5 from from IN cord-010092-uftc8inx 4696 6 a a DT cord-010092-uftc8inx 4696 7 quality quality NN cord-010092-uftc8inx 4696 8 management management NN cord-010092-uftc8inx 4696 9 system system NN cord-010092-uftc8inx 4696 10 that that WDT cord-010092-uftc8inx 4696 11 brings bring VBZ cord-010092-uftc8inx 4696 12 you -PRON- PRP cord-010092-uftc8inx 4696 13 into into IN cord-010092-uftc8inx 4696 14 line line NN cord-010092-uftc8inx 4696 15 with with IN cord-010092-uftc8inx 4696 16 international international JJ cord-010092-uftc8inx 4696 17 standards standard NNS cord-010092-uftc8inx 4696 18 . . . cord-010092-uftc8inx 4697 1 Ensuring ensure VBG cord-010092-uftc8inx 4697 2 the the DT cord-010092-uftc8inx 4697 3 quality quality NN cord-010092-uftc8inx 4697 4 of of IN cord-010092-uftc8inx 4697 5 our -PRON- PRP$ cord-010092-uftc8inx 4697 6 services service NNS cord-010092-uftc8inx 4697 7 and and CC cord-010092-uftc8inx 4697 8 products product NNS cord-010092-uftc8inx 4697 9 is be VBZ cord-010092-uftc8inx 4697 10 essential essential JJ cord-010092-uftc8inx 4697 11 to to TO cord-010092-uftc8inx 4697 12 keep keep VB cord-010092-uftc8inx 4697 13 safe safe JJ cord-010092-uftc8inx 4697 14 and and CC cord-010092-uftc8inx 4697 15 strong strong JJ cord-010092-uftc8inx 4697 16 blood blood NN cord-010092-uftc8inx 4697 17 transfusion transfusion NN cord-010092-uftc8inx 4697 18 service service NN cord-010092-uftc8inx 4697 19 . . . cord-010092-uftc8inx 4698 1 Background background NN cord-010092-uftc8inx 4698 2 : : : cord-010092-uftc8inx 4699 1 Implementation implementation NN cord-010092-uftc8inx 4699 2 of of IN cord-010092-uftc8inx 4699 3 robust robust JJ cord-010092-uftc8inx 4699 4 quality quality NN cord-010092-uftc8inx 4699 5 assurance assurance NN cord-010092-uftc8inx 4699 6 program program NN cord-010092-uftc8inx 4699 7 is be VBZ cord-010092-uftc8inx 4699 8 key key JJ cord-010092-uftc8inx 4699 9 to to IN cord-010092-uftc8inx 4699 10 high high JJ cord-010092-uftc8inx 4699 11 performing perform VBG cord-010092-uftc8inx 4699 12 blood blood NN cord-010092-uftc8inx 4699 13 establishments establishment NNS cord-010092-uftc8inx 4699 14 . . . cord-010092-uftc8inx 4700 1 Quality quality NN cord-010092-uftc8inx 4700 2 control control NN cord-010092-uftc8inx 4700 3 and and CC cord-010092-uftc8inx 4700 4 quality quality NN cord-010092-uftc8inx 4700 5 assurance assurance NN cord-010092-uftc8inx 4700 6 systems system NNS cord-010092-uftc8inx 4700 7 together together RB cord-010092-uftc8inx 4700 8 constitute constitute VBP cord-010092-uftc8inx 4700 9 the the DT cord-010092-uftc8inx 4700 10 key key JJ cord-010092-uftc8inx 4700 11 quality quality NN cord-010092-uftc8inx 4700 12 systems system NNS cord-010092-uftc8inx 4700 13 and and CC cord-010092-uftc8inx 4700 14 are be VBP cord-010092-uftc8inx 4700 15 parts part NNS cord-010092-uftc8inx 4700 16 of of IN cord-010092-uftc8inx 4700 17 quality quality NN cord-010092-uftc8inx 4700 18 management management NN cord-010092-uftc8inx 4700 19 . . . cord-010092-uftc8inx 4701 1 Effective effective JJ cord-010092-uftc8inx 4701 2 and and CC cord-010092-uftc8inx 4701 3 efficient efficient JJ cord-010092-uftc8inx 4701 4 quality quality NN cord-010092-uftc8inx 4701 5 control control NN cord-010092-uftc8inx 4701 6 policies policy NNS cord-010092-uftc8inx 4701 7 not not RB cord-010092-uftc8inx 4701 8 only only RB cord-010092-uftc8inx 4701 9 provide provide VBP cord-010092-uftc8inx 4701 10 guidance guidance NN cord-010092-uftc8inx 4701 11 that that WDT cord-010092-uftc8inx 4701 12 help help VBP cord-010092-uftc8inx 4701 13 to to TO cord-010092-uftc8inx 4701 14 increase increase VB cord-010092-uftc8inx 4701 15 the the DT cord-010092-uftc8inx 4701 16 reliability reliability NN cord-010092-uftc8inx 4701 17 of of IN cord-010092-uftc8inx 4701 18 results result NNS cord-010092-uftc8inx 4701 19 but but CC cord-010092-uftc8inx 4701 20 also also RB cord-010092-uftc8inx 4701 21 maintains maintain VBZ cord-010092-uftc8inx 4701 22 the the DT cord-010092-uftc8inx 4701 23 laboratory laboratory NN cord-010092-uftc8inx 4701 24 's 's POS cord-010092-uftc8inx 4701 25 consistence consistence NN cord-010092-uftc8inx 4701 26 performance performance NN cord-010092-uftc8inx 4701 27 overtime overtime NN cord-010092-uftc8inx 4701 28 . . . cord-010092-uftc8inx 4702 1 Aims aim VBZ cord-010092-uftc8inx 4702 2 : : : cord-010092-uftc8inx 4703 1 Therefore therefore RB cord-010092-uftc8inx 4703 2 , , , cord-010092-uftc8inx 4703 3 we -PRON- PRP cord-010092-uftc8inx 4703 4 established establish VBD cord-010092-uftc8inx 4703 5 a a DT cord-010092-uftc8inx 4703 6 set set NN cord-010092-uftc8inx 4703 7 of of IN cord-010092-uftc8inx 4703 8 QC QC NNP cord-010092-uftc8inx 4703 9 limit limit NN cord-010092-uftc8inx 4703 10 using use VBG cord-010092-uftc8inx 4703 11 historical historical JJ cord-010092-uftc8inx 4703 12 data datum NNS cord-010092-uftc8inx 4703 13 which which WDT cord-010092-uftc8inx 4703 14 can can MD cord-010092-uftc8inx 4703 15 timely timely RB cord-010092-uftc8inx 4703 16 identify identify VB cord-010092-uftc8inx 4703 17 unexpected unexpected JJ cord-010092-uftc8inx 4703 18 variation variation NN cord-010092-uftc8inx 4703 19 in in IN cord-010092-uftc8inx 4703 20 the the DT cord-010092-uftc8inx 4703 21 testing testing NN cord-010092-uftc8inx 4703 22 systems system NNS cord-010092-uftc8inx 4703 23 and and CC cord-010092-uftc8inx 4703 24 trigger trigger VB cord-010092-uftc8inx 4703 25 a a DT cord-010092-uftc8inx 4703 26 review review NN cord-010092-uftc8inx 4703 27 of of IN cord-010092-uftc8inx 4703 28 test test NN cord-010092-uftc8inx 4703 29 processes process NNS cord-010092-uftc8inx 4703 30 in in IN cord-010092-uftc8inx 4703 31 blood blood NN cord-010092-uftc8inx 4703 32 screening screening NN cord-010092-uftc8inx 4703 33 laboratories laboratory NNS cord-010092-uftc8inx 4703 34 as as IN cord-010092-uftc8inx 4703 35 part part NN cord-010092-uftc8inx 4703 36 of of IN cord-010092-uftc8inx 4703 37 quality quality NN cord-010092-uftc8inx 4703 38 assurance assurance NN cord-010092-uftc8inx 4703 39 system system NN cord-010092-uftc8inx 4703 40 . . . cord-010092-uftc8inx 4704 1 Methods method NNS cord-010092-uftc8inx 4704 2 : : : cord-010092-uftc8inx 4705 1 Last last JJ cord-010092-uftc8inx 4705 2 two two CD cord-010092-uftc8inx 4705 3 consecutive consecutive JJ cord-010092-uftc8inx 4705 4 years year NNS cord-010092-uftc8inx 4705 5 ( ( -LRB- cord-010092-uftc8inx 4705 6 Jan Jan NNP cord-010092-uftc8inx 4705 7 , , , cord-010092-uftc8inx 4705 8 2017 2017 CD cord-010092-uftc8inx 4705 9 to to IN cord-010092-uftc8inx 4705 10 Dec Dec NNP cord-010092-uftc8inx 4705 11 , , , cord-010092-uftc8inx 4705 12 2018 2018 CD cord-010092-uftc8inx 4705 13 ) ) -RRB- cord-010092-uftc8inx 4706 1 QC QC NNP cord-010092-uftc8inx 4706 2 data datum NNS cord-010092-uftc8inx 4706 3 from from IN cord-010092-uftc8inx 4706 4 ARCHI ARCHI NNP cord-010092-uftc8inx 4706 5 - - HYPH cord-010092-uftc8inx 4706 6 TECT TECT NNP cord-010092-uftc8inx 4706 7 i2000SR i2000sr JJ cord-010092-uftc8inx 4706 8 ( ( -LRB- cord-010092-uftc8inx 4706 9 Abbott Abbott NNP cord-010092-uftc8inx 4706 10 Laboratories Laboratories NNP cord-010092-uftc8inx 4706 11 , , , cord-010092-uftc8inx 4706 12 Chicago Chicago NNP cord-010092-uftc8inx 4706 13 ) ) -RRB- cord-010092-uftc8inx 4706 14 was be VBD cord-010092-uftc8inx 4706 15 extracted extract VBN cord-010092-uftc8inx 4706 16 using use VBG cord-010092-uftc8inx 4706 17 AbbottLink AbbottLink NNP cord-010092-uftc8inx 4706 18 for for IN cord-010092-uftc8inx 4706 19 Philippines Philippines NNP cord-010092-uftc8inx 4706 20 Red Red NNP cord-010092-uftc8inx 4706 21 Cross Cross NNP cord-010092-uftc8inx 4706 22 Tower Tower NNP cord-010092-uftc8inx 4706 23 National National NNP cord-010092-uftc8inx 4706 24 Blood Blood NNP cord-010092-uftc8inx 4706 25 Center Center NNP cord-010092-uftc8inx 4706 26 Total Total NNP cord-010092-uftc8inx 4706 27 of of IN cord-010092-uftc8inx 4706 28 6532 6532 CD cord-010092-uftc8inx 4706 29 data data NN cord-010092-uftc8inx 4706 30 points point NNS cord-010092-uftc8inx 4706 31 ( ( -LRB- cord-010092-uftc8inx 4706 32 3523 3523 CD cord-010092-uftc8inx 4706 33 data data NN cord-010092-uftc8inx 4706 34 points point NNS cord-010092-uftc8inx 4706 35 in in IN cord-010092-uftc8inx 4706 36 2017 2017 CD cord-010092-uftc8inx 4706 37 & & CC cord-010092-uftc8inx 4706 38 3009 3009 CD cord-010092-uftc8inx 4706 39 data data NN cord-010092-uftc8inx 4706 40 points point NNS cord-010092-uftc8inx 4706 41 in in IN cord-010092-uftc8inx 4706 42 2018 2018 CD cord-010092-uftc8inx 4706 43 ) ) -RRB- cord-010092-uftc8inx 4706 44 were be VBD cord-010092-uftc8inx 4706 45 obtained obtain VBN cord-010092-uftc8inx 4706 46 for for IN cord-010092-uftc8inx 4706 47 10 10 CD cord-010092-uftc8inx 4706 48 different different JJ cord-010092-uftc8inx 4706 49 QC QC NNP cord-010092-uftc8inx 4706 50 levels level NNS cord-010092-uftc8inx 4706 51 for for IN cord-010092-uftc8inx 4706 52 four four CD cord-010092-uftc8inx 4706 53 serological serological JJ cord-010092-uftc8inx 4706 54 blood blood NN cord-010092-uftc8inx 4706 55 screening screening NN cord-010092-uftc8inx 4706 56 assays assay NNS cord-010092-uftc8inx 4706 57 ( ( -LRB- cord-010092-uftc8inx 4706 58 HIV HIV NNP cord-010092-uftc8inx 4706 59 combo combo NN cord-010092-uftc8inx 4706 60 , , , cord-010092-uftc8inx 4706 61 HBsAg hbsag ADD cord-010092-uftc8inx 4706 62 , , , cord-010092-uftc8inx 4706 63 anti anti JJ cord-010092-uftc8inx 4706 64 - - NNP cord-010092-uftc8inx 4706 65 HCV HCV NNP cord-010092-uftc8inx 4706 66 , , , cord-010092-uftc8inx 4706 67 Syphilis Syphilis NNP cord-010092-uftc8inx 4706 68 ) ) -RRB- cord-010092-uftc8inx 4706 69 . . . cord-010092-uftc8inx 4707 1 The the DT cord-010092-uftc8inx 4707 2 data datum NNS cord-010092-uftc8inx 4707 3 was be VBD cord-010092-uftc8inx 4707 4 sorted sort VBN cord-010092-uftc8inx 4707 5 for for IN cord-010092-uftc8inx 4707 6 each each DT cord-010092-uftc8inx 4707 7 assay assay NN cord-010092-uftc8inx 4707 8 / / NFP cord-010092-uftc8inx 4707 9 Lot Lot NNP cord-010092-uftc8inx 4707 10 and and CC cord-010092-uftc8inx 4707 11 QC QC NNP cord-010092-uftc8inx 4707 12 level level NN cord-010092-uftc8inx 4707 13 combination combination NN cord-010092-uftc8inx 4707 14 by by IN cord-010092-uftc8inx 4707 15 year year NN cord-010092-uftc8inx 4707 16 . . . cord-010092-uftc8inx 4708 1 QC QC NNP cord-010092-uftc8inx 4708 2 limits limit NNS cord-010092-uftc8inx 4708 3 were be VBD cord-010092-uftc8inx 4708 4 calculated calculate VBN cord-010092-uftc8inx 4708 5 using use VBG cord-010092-uftc8inx 4708 6 simple simple JJ cord-010092-uftc8inx 4708 7 mean mean NN cord-010092-uftc8inx 4708 8 , , , cord-010092-uftc8inx 4708 9 standard standard JJ cord-010092-uftc8inx 4708 10 deviation deviation NN cord-010092-uftc8inx 4708 11 ( ( -LRB- cord-010092-uftc8inx 4708 12 SD sd NN cord-010092-uftc8inx 4708 13 ) ) -RRB- cord-010092-uftc8inx 4708 14 and and CC cord-010092-uftc8inx 4708 15 coefficient coefficient NN cord-010092-uftc8inx 4708 16 of of IN cord-010092-uftc8inx 4708 17 variation variation NN cord-010092-uftc8inx 4708 18 ( ( -LRB- cord-010092-uftc8inx 4708 19 CV% CV% NNP cord-010092-uftc8inx 4708 20 ) ) -RRB- cord-010092-uftc8inx 4708 21 and and CC cord-010092-uftc8inx 4708 22 were be VBD cord-010092-uftc8inx 4708 23 validated validate VBN cord-010092-uftc8inx 4708 24 and and CC cord-010092-uftc8inx 4708 25 compared compare VBN cord-010092-uftc8inx 4708 26 with with IN cord-010092-uftc8inx 4708 27 manufacturer manufacturer NN cord-010092-uftc8inx 4708 28 's 's POS cord-010092-uftc8inx 4708 29 recommendation recommendation NN cord-010092-uftc8inx 4708 30 . . . cord-010092-uftc8inx 4709 1 Results result NNS cord-010092-uftc8inx 4709 2 : : : cord-010092-uftc8inx 4710 1 All all PDT cord-010092-uftc8inx 4710 2 the the DT cord-010092-uftc8inx 4710 3 six six CD cord-010092-uftc8inx 4710 4 positive positive JJ cord-010092-uftc8inx 4710 5 quality quality NN cord-010092-uftc8inx 4710 6 control control NN cord-010092-uftc8inx 4710 7 levels level NNS cord-010092-uftc8inx 4710 8 CV% CV% NNP cord-010092-uftc8inx 4711 1 ( ( -LRB- cord-010092-uftc8inx 4711 2 5.70 5.70 CD cord-010092-uftc8inx 4711 3 - - SYM cord-010092-uftc8inx 4711 4 12.05 12.05 CD cord-010092-uftc8inx 4711 5 ) ) -RRB- cord-010092-uftc8inx 4711 6 were be VBD cord-010092-uftc8inx 4711 7 within within IN cord-010092-uftc8inx 4711 8 manufacturer manufacturer NN cord-010092-uftc8inx 4711 9 's 's POS cord-010092-uftc8inx 4711 10 precision precision NN cord-010092-uftc8inx 4711 11 recommendation recommendation NN cord-010092-uftc8inx 4711 12 ( ( -LRB- cord-010092-uftc8inx 4711 13 within within IN cord-010092-uftc8inx 4711 14 lab lab NN cord-010092-uftc8inx 4711 15 precision precision NN cord-010092-uftc8inx 4711 16 HBsAg hbsag ADD cord-010092-uftc8inx 4711 17 ≤ ≤ NNP cord-010092-uftc8inx 4711 18 10 10 CD cord-010092-uftc8inx 4711 19 % % NN cord-010092-uftc8inx 4711 20 , , , cord-010092-uftc8inx 4711 21 Anti Anti NNP cord-010092-uftc8inx 4711 22 - - NNP cord-010092-uftc8inx 4711 23 HCV HCV NNP cord-010092-uftc8inx 4711 24 ≤ ≤ NNP cord-010092-uftc8inx 4711 25 15 15 CD cord-010092-uftc8inx 4711 26 % % NN cord-010092-uftc8inx 4711 27 , , , cord-010092-uftc8inx 4711 28 Syphilis Syphilis NNP cord-010092-uftc8inx 4711 29 ≤ ≤ NNP cord-010092-uftc8inx 4711 30 15 15 CD cord-010092-uftc8inx 4711 31 % % NN cord-010092-uftc8inx 4711 32 , , , cord-010092-uftc8inx 4711 33 HIV HIV NNP cord-010092-uftc8inx 4711 34 ≤ ≤ NNP cord-010092-uftc8inx 4711 35 14 14 CD cord-010092-uftc8inx 4711 36 % % NN cord-010092-uftc8inx 4711 37 ) ) -RRB- cord-010092-uftc8inx 4711 38 in in IN cord-010092-uftc8inx 4711 39 2018 2018 CD cord-010092-uftc8inx 4711 40 . . . cord-010092-uftc8inx 4712 1 Five five CD cord-010092-uftc8inx 4712 2 out out IN cord-010092-uftc8inx 4712 3 of of IN cord-010092-uftc8inx 4712 4 six six CD cord-010092-uftc8inx 4712 5 positive positive JJ cord-010092-uftc8inx 4712 6 quality quality NN cord-010092-uftc8inx 4712 7 control control NN cord-010092-uftc8inx 4712 8 levels level NNS cord-010092-uftc8inx 4712 9 CV% CV% NNP cord-010092-uftc8inx 4713 1 ( ( -LRB- cord-010092-uftc8inx 4713 2 5.72 5.72 CD cord-010092-uftc8inx 4713 3 - - SYM cord-010092-uftc8inx 4713 4 15.80 15.80 CD cord-010092-uftc8inx 4713 5 ) ) -RRB- cord-010092-uftc8inx 4713 6 showed show VBD cord-010092-uftc8inx 4713 7 within within IN cord-010092-uftc8inx 4713 8 manufacturer manufacturer NN cord-010092-uftc8inx 4713 9 's 's POS cord-010092-uftc8inx 4713 10 precision precision NN cord-010092-uftc8inx 4713 11 recommendation recommendation NN cord-010092-uftc8inx 4713 12 ( ( -LRB- cord-010092-uftc8inx 4713 13 within within IN cord-010092-uftc8inx 4713 14 lab lab NN cord-010092-uftc8inx 4713 15 precision precision NN cord-010092-uftc8inx 4713 16 HBsAg hbsag ADD cord-010092-uftc8inx 4713 17 ≤ ≤ NNP cord-010092-uftc8inx 4713 18 10 10 CD cord-010092-uftc8inx 4713 19 % % NN cord-010092-uftc8inx 4713 20 , , , cord-010092-uftc8inx 4713 21 Anti Anti NNP cord-010092-uftc8inx 4713 22 - - NNP cord-010092-uftc8inx 4713 23 HCV HCV NNP cord-010092-uftc8inx 4713 24 ≤ ≤ NNP cord-010092-uftc8inx 4713 25 15 15 CD cord-010092-uftc8inx 4713 26 % % NN cord-010092-uftc8inx 4713 27 , , , cord-010092-uftc8inx 4713 28 Syphilis Syphilis NNP cord-010092-uftc8inx 4713 29 ≤ ≤ NNP cord-010092-uftc8inx 4713 30 15 15 CD cord-010092-uftc8inx 4713 31 % % NN cord-010092-uftc8inx 4713 32 , , , cord-010092-uftc8inx 4713 33 HIV HIV NNP cord-010092-uftc8inx 4713 34 ≤ ≤ NNP cord-010092-uftc8inx 4713 35 14 14 CD cord-010092-uftc8inx 4713 36 % % NN cord-010092-uftc8inx 4713 37 ) ) -RRB- cord-010092-uftc8inx 4713 38 in in IN cord-010092-uftc8inx 4713 39 2017 2017 CD cord-010092-uftc8inx 4713 40 except except IN cord-010092-uftc8inx 4713 41 Syphilis Syphilis NNP cord-010092-uftc8inx 4713 42 TP TP NNP cord-010092-uftc8inx 4713 43 positive positive JJ cord-010092-uftc8inx 4713 44 control control NN cord-010092-uftc8inx 4713 45 ( ( -LRB- cord-010092-uftc8inx 4713 46 15.8 15.8 CD cord-010092-uftc8inx 4713 47 % % NN cord-010092-uftc8inx 4713 48 ) ) -RRB- cord-010092-uftc8inx 4713 49 . . . cord-010092-uftc8inx 4714 1 All all DT cord-010092-uftc8inx 4714 2 four four CD cord-010092-uftc8inx 4714 3 negative negative JJ cord-010092-uftc8inx 4714 4 quality quality NN cord-010092-uftc8inx 4714 5 control control NN cord-010092-uftc8inx 4714 6 levels level NNS cord-010092-uftc8inx 4714 7 showed show VBD cord-010092-uftc8inx 4714 8 the the DT cord-010092-uftc8inx 4714 9 SD sd NN cord-010092-uftc8inx 4714 10 values value NNS cord-010092-uftc8inx 4714 11 within within IN cord-010092-uftc8inx 4714 12 0.009 0.009 CD cord-010092-uftc8inx 4714 13 - - SYM cord-010092-uftc8inx 4714 14 0.41 0.41 CD cord-010092-uftc8inx 4714 15 in in IN cord-010092-uftc8inx 4714 16 2017 2017 CD cord-010092-uftc8inx 4714 17 and and CC cord-010092-uftc8inx 4714 18 0.009 0.009 CD cord-010092-uftc8inx 4714 19 - - SYM cord-010092-uftc8inx 4714 20 0.41 0.41 CD cord-010092-uftc8inx 4714 21 in in IN cord-010092-uftc8inx 4714 22 2018 2018 CD cord-010092-uftc8inx 4714 23 respectively respectively RB cord-010092-uftc8inx 4714 24 . . . cord-010092-uftc8inx 4715 1 Summary Summary NNP cord-010092-uftc8inx 4715 2 / / SYM cord-010092-uftc8inx 4715 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 4715 4 : : : cord-010092-uftc8inx 4716 1 Excellent excellent JJ cord-010092-uftc8inx 4716 2 QC QC NNP cord-010092-uftc8inx 4716 3 performance performance NN cord-010092-uftc8inx 4716 4 was be VBD cord-010092-uftc8inx 4716 5 observed observe VBN cord-010092-uftc8inx 4716 6 in in IN cord-010092-uftc8inx 4716 7 Philippines Philippines NNP cord-010092-uftc8inx 4716 8 Red Red NNP cord-010092-uftc8inx 4716 9 Cross Cross NNP cord-010092-uftc8inx 4716 10 Tower Tower NNP cord-010092-uftc8inx 4716 11 National National NNP cord-010092-uftc8inx 4716 12 Blood Blood NNP cord-010092-uftc8inx 4716 13 Center Center NNP cord-010092-uftc8inx 4716 14 blood blood NN cord-010092-uftc8inx 4716 15 screening screening NN cord-010092-uftc8inx 4716 16 laboratory laboratory NN cord-010092-uftc8inx 4716 17 based base VBN cord-010092-uftc8inx 4716 18 on on IN cord-010092-uftc8inx 4716 19 historical historical JJ cord-010092-uftc8inx 4716 20 data datum NNS cord-010092-uftc8inx 4716 21 and and CC cord-010092-uftc8inx 4716 22 evidence evidence NN cord-010092-uftc8inx 4716 23 - - HYPH cord-010092-uftc8inx 4716 24 based base VBN cord-010092-uftc8inx 4716 25 laboratory laboratory NN cord-010092-uftc8inx 4716 26 QC QC NNP cord-010092-uftc8inx 4716 27 limit limit NN cord-010092-uftc8inx 4716 28 for for IN cord-010092-uftc8inx 4716 29 blood blood NN cord-010092-uftc8inx 4716 30 screening screening NN cord-010092-uftc8inx 4716 31 assays assay NNS cord-010092-uftc8inx 4716 32 were be VBD cord-010092-uftc8inx 4716 33 established establish VBN cord-010092-uftc8inx 4716 34 using use VBG cord-010092-uftc8inx 4716 35 historical historical JJ cord-010092-uftc8inx 4716 36 data datum NNS cord-010092-uftc8inx 4716 37 which which WDT cord-010092-uftc8inx 4716 38 takes take VBZ cord-010092-uftc8inx 4716 39 into into IN cord-010092-uftc8inx 4716 40 account account NN cord-010092-uftc8inx 4716 41 total total JJ cord-010092-uftc8inx 4716 42 variation variation NN cord-010092-uftc8inx 4716 43 expected expect VBN cord-010092-uftc8inx 4716 44 in in IN cord-010092-uftc8inx 4716 45 a a DT cord-010092-uftc8inx 4716 46 test test NN cord-010092-uftc8inx 4716 47 system system NN cord-010092-uftc8inx 4716 48 and and CC cord-010092-uftc8inx 4716 49 offers offer VBZ cord-010092-uftc8inx 4716 50 a a DT cord-010092-uftc8inx 4716 51 more more RBR cord-010092-uftc8inx 4716 52 robust robust JJ cord-010092-uftc8inx 4716 53 and and CC cord-010092-uftc8inx 4716 54 meaningful meaningful JJ cord-010092-uftc8inx 4716 55 mechanism mechanism NN cord-010092-uftc8inx 4716 56 for for IN cord-010092-uftc8inx 4716 57 setting set VBG cord-010092-uftc8inx 4716 58 control control NN cord-010092-uftc8inx 4716 59 limits limit NNS cord-010092-uftc8inx 4716 60 , , , cord-010092-uftc8inx 4716 61 for for IN cord-010092-uftc8inx 4716 62 the the DT cord-010092-uftc8inx 4716 63 first first JJ cord-010092-uftc8inx 4716 64 time time NN cord-010092-uftc8inx 4716 65 . . . cord-010092-uftc8inx 4717 1 Background background NN cord-010092-uftc8inx 4717 2 : : : cord-010092-uftc8inx 4718 1 Quality Quality NNP cord-010092-uftc8inx 4718 2 Indicators Indicators NNP cord-010092-uftc8inx 4718 3 ( ( -LRB- cord-010092-uftc8inx 4718 4 QI QI NNP cord-010092-uftc8inx 4718 5 ) ) -RRB- cord-010092-uftc8inx 4718 6 in in IN cord-010092-uftc8inx 4718 7 Transfusion Transfusion NNP cord-010092-uftc8inx 4718 8 Medicine Medicine NNP cord-010092-uftc8inx 4718 9 ( ( -LRB- cord-010092-uftc8inx 4718 10 TM TM NNP cord-010092-uftc8inx 4718 11 ) ) -RRB- cord-010092-uftc8inx 4718 12 are be VBP cord-010092-uftc8inx 4718 13 ' ' `` cord-010092-uftc8inx 4718 14 Critically critically RB cord-010092-uftc8inx 4718 15 important important JJ cord-010092-uftc8inx 4718 16 aspects aspect NNS cord-010092-uftc8inx 4718 17 of of IN cord-010092-uftc8inx 4718 18 Transfusion Transfusion NNP cord-010092-uftc8inx 4718 19 Medicine Medicine NNP cord-010092-uftc8inx 4718 20 practice practice NN cord-010092-uftc8inx 4718 21 that that WDT cord-010092-uftc8inx 4718 22 are be VBP cord-010092-uftc8inx 4718 23 measured measure VBN cord-010092-uftc8inx 4718 24 and and CC cord-010092-uftc8inx 4718 25 utilized utilize VBN cord-010092-uftc8inx 4718 26 to to TO cord-010092-uftc8inx 4718 27 gain gain VB cord-010092-uftc8inx 4718 28 insight insight NN cord-010092-uftc8inx 4718 29 for for IN cord-010092-uftc8inx 4718 30 continuous continuous JJ cord-010092-uftc8inx 4718 31 quality quality NN cord-010092-uftc8inx 4718 32 improvement improvement NN cord-010092-uftc8inx 4718 33 , , , cord-010092-uftc8inx 4718 34 into into IN cord-010092-uftc8inx 4718 35 the the DT cord-010092-uftc8inx 4718 36 degree degree NN cord-010092-uftc8inx 4718 37 to to TO cord-010092-uftc8inx 4718 38 which which WDT cord-010092-uftc8inx 4718 39 the the DT cord-010092-uftc8inx 4718 40 TM TM NNP cord-010092-uftc8inx 4718 41 is be VBZ cord-010092-uftc8inx 4718 42 capable capable JJ cord-010092-uftc8inx 4718 43 of of IN cord-010092-uftc8inx 4718 44 providing provide VBG cord-010092-uftc8inx 4718 45 quality quality NN cord-010092-uftc8inx 4718 46 TM TM NNP cord-010092-uftc8inx 4718 47 care care NN cord-010092-uftc8inx 4718 48 , , , cord-010092-uftc8inx 4718 49 products product NNS cord-010092-uftc8inx 4718 50 or or CC cord-010092-uftc8inx 4718 51 services service NNS cord-010092-uftc8inx 4718 52 for for IN cord-010092-uftc8inx 4718 53 the the DT cord-010092-uftc8inx 4718 54 aspect aspect NN cord-010092-uftc8inx 4718 55 of of IN cord-010092-uftc8inx 4718 56 practice practice NN cord-010092-uftc8inx 4718 57 measured measure VBN cord-010092-uftc8inx 4718 58 following follow VBG cord-010092-uftc8inx 4718 59 comparison comparison NN cord-010092-uftc8inx 4718 60 of of IN cord-010092-uftc8inx 4718 61 the the DT cord-010092-uftc8inx 4718 62 measurement measurement NN cord-010092-uftc8inx 4718 63 against against IN cord-010092-uftc8inx 4718 64 acceptable acceptable JJ cord-010092-uftc8inx 4718 65 local local JJ cord-010092-uftc8inx 4718 66 or or CC cord-010092-uftc8inx 4718 67 international international JJ cord-010092-uftc8inx 4718 68 reference reference NN cord-010092-uftc8inx 4718 69 thresholds threshold NNS cord-010092-uftc8inx 4718 70 , , , cord-010092-uftc8inx 4718 71 benchmarks benchmark NNS cord-010092-uftc8inx 4718 72 , , , cord-010092-uftc8inx 4718 73 standards standard NNS cord-010092-uftc8inx 4718 74 , , , cord-010092-uftc8inx 4718 75 or or CC cord-010092-uftc8inx 4718 76 practice practice VB cord-010092-uftc8inx 4718 77 guidelines guideline NNS cord-010092-uftc8inx 4718 78 ' ' '' cord-010092-uftc8inx 4718 79 . . . cord-010092-uftc8inx 4719 1 The the DT cord-010092-uftc8inx 4719 2 critical critical JJ cord-010092-uftc8inx 4719 3 control control NN cord-010092-uftc8inx 4719 4 point point NN cord-010092-uftc8inx 4719 5 ( ( -LRB- cord-010092-uftc8inx 4719 6 CCP CCP NNP cord-010092-uftc8inx 4719 7 ) ) -RRB- cord-010092-uftc8inx 4719 8 selected select VBN cord-010092-uftc8inx 4719 9 for for IN cord-010092-uftc8inx 4719 10 this this DT cord-010092-uftc8inx 4719 11 study study NN cord-010092-uftc8inx 4719 12 is be VBZ cord-010092-uftc8inx 4719 13 ' ' `` cord-010092-uftc8inx 4719 14 Administration administration NN cord-010092-uftc8inx 4719 15 techniques technique NNS cord-010092-uftc8inx 4719 16 and and CC cord-010092-uftc8inx 4719 17 monitoring monitoring NN cord-010092-uftc8inx 4719 18 of of IN cord-010092-uftc8inx 4719 19 key key JJ cord-010092-uftc8inx 4719 20 elements element NNS cord-010092-uftc8inx 4719 21 ' ' '' cord-010092-uftc8inx 4719 22 . . . cord-010092-uftc8inx 4720 1 This this DT cord-010092-uftc8inx 4720 2 has have VBZ cord-010092-uftc8inx 4720 3 been be VBN cord-010092-uftc8inx 4720 4 selected select VBN cord-010092-uftc8inx 4720 5 since since IN cord-010092-uftc8inx 4720 6 the the DT cord-010092-uftc8inx 4720 7 clinical clinical JJ cord-010092-uftc8inx 4720 8 fraternity fraternity NN cord-010092-uftc8inx 4720 9 plays play VBZ cord-010092-uftc8inx 4720 10 a a DT cord-010092-uftc8inx 4720 11 larger large JJR cord-010092-uftc8inx 4720 12 role role NN cord-010092-uftc8inx 4720 13 in in IN cord-010092-uftc8inx 4720 14 ensuring ensure VBG cord-010092-uftc8inx 4720 15 quality quality NN cord-010092-uftc8inx 4720 16 services service NNS cord-010092-uftc8inx 4720 17 in in IN cord-010092-uftc8inx 4720 18 administration administration NN cord-010092-uftc8inx 4720 19 of of IN cord-010092-uftc8inx 4720 20 blood blood NN cord-010092-uftc8inx 4720 21 components component NNS cord-010092-uftc8inx 4720 22 . . . cord-010092-uftc8inx 4721 1 There there EX cord-010092-uftc8inx 4721 2 was be VBD cord-010092-uftc8inx 4721 3 a a DT cord-010092-uftc8inx 4721 4 need need NN cord-010092-uftc8inx 4721 5 to to TO cord-010092-uftc8inx 4721 6 follow follow VB cord-010092-uftc8inx 4721 7 up up RP cord-010092-uftc8inx 4721 8 compliance compliance NN cord-010092-uftc8inx 4721 9 to to IN cord-010092-uftc8inx 4721 10 standard standard JJ cord-010092-uftc8inx 4721 11 protocol protocol NN cord-010092-uftc8inx 4721 12 for for IN cord-010092-uftc8inx 4721 13 bedside bedside NN cord-010092-uftc8inx 4721 14 transfusion transfusion NN cord-010092-uftc8inx 4721 15 practices practice NNS cord-010092-uftc8inx 4721 16 hence hence RB cord-010092-uftc8inx 4721 17 was be VBD cord-010092-uftc8inx 4721 18 decided decide VBN cord-010092-uftc8inx 4721 19 to to TO cord-010092-uftc8inx 4721 20 study study VB cord-010092-uftc8inx 4721 21 the the DT cord-010092-uftc8inx 4721 22 same same JJ cord-010092-uftc8inx 4721 23 with with IN cord-010092-uftc8inx 4721 24 four four CD cord-010092-uftc8inx 4721 25 selected select VBN cord-010092-uftc8inx 4721 26 quality quality NN cord-010092-uftc8inx 4721 27 indicators indicator NNS cord-010092-uftc8inx 4721 28 and and CC cord-010092-uftc8inx 4721 29 introduce introduce VB cord-010092-uftc8inx 4721 30 corrective corrective JJ cord-010092-uftc8inx 4721 31 measures measure NNS cord-010092-uftc8inx 4721 32 if if IN cord-010092-uftc8inx 4721 33 necessary necessary JJ cord-010092-uftc8inx 4721 34 . . . cord-010092-uftc8inx 4722 1 Aims aim VBZ cord-010092-uftc8inx 4722 2 : : : cord-010092-uftc8inx 4722 3 1 1 LS cord-010092-uftc8inx 4722 4 . . . cord-010092-uftc8inx 4723 1 To to TO cord-010092-uftc8inx 4723 2 assess assess VB cord-010092-uftc8inx 4723 3 the the DT cord-010092-uftc8inx 4723 4 existing exist VBG cord-010092-uftc8inx 4723 5 transfusion transfusion NN cord-010092-uftc8inx 4723 6 practices practice NNS cord-010092-uftc8inx 4723 7 in in IN cord-010092-uftc8inx 4723 8 the the DT cord-010092-uftc8inx 4723 9 institute institute NN cord-010092-uftc8inx 4723 10 with with IN cord-010092-uftc8inx 4723 11 specific specific JJ cord-010092-uftc8inx 4723 12 quality quality NN cord-010092-uftc8inx 4723 13 indicators indicator NNS cord-010092-uftc8inx 4723 14 2 2 CD cord-010092-uftc8inx 4723 15 . . . cord-010092-uftc8inx 4724 1 To to TO cord-010092-uftc8inx 4724 2 introduce introduce VB cord-010092-uftc8inx 4724 3 corrective corrective JJ cord-010092-uftc8inx 4724 4 reforms reform NNS cord-010092-uftc8inx 4724 5 to to TO cord-010092-uftc8inx 4724 6 improve improve VB cord-010092-uftc8inx 4724 7 the the DT cord-010092-uftc8inx 4724 8 existing exist VBG cord-010092-uftc8inx 4724 9 practice practice NN cord-010092-uftc8inx 4724 10 3 3 CD cord-010092-uftc8inx 4724 11 . . . cord-010092-uftc8inx 4725 1 To to TO cord-010092-uftc8inx 4725 2 assess assess VB cord-010092-uftc8inx 4725 3 the the DT cord-010092-uftc8inx 4725 4 transfusion transfusion NN cord-010092-uftc8inx 4725 5 practices practice NNS cord-010092-uftc8inx 4725 6 after after IN cord-010092-uftc8inx 4725 7 interventions intervention NNS cord-010092-uftc8inx 4725 8 using use VBG cord-010092-uftc8inx 4725 9 the the DT cord-010092-uftc8inx 4725 10 same same JJ cord-010092-uftc8inx 4725 11 quality quality NN cord-010092-uftc8inx 4725 12 indicators indicator NNS cord-010092-uftc8inx 4725 13 Methods method NNS cord-010092-uftc8inx 4725 14 : : : cord-010092-uftc8inx 4726 1 To to TO cord-010092-uftc8inx 4726 2 assess assess VB cord-010092-uftc8inx 4726 3 the the DT cord-010092-uftc8inx 4726 4 existing exist VBG cord-010092-uftc8inx 4726 5 transfusion transfusion NN cord-010092-uftc8inx 4726 6 practices practice NNS cord-010092-uftc8inx 4726 7 in in IN cord-010092-uftc8inx 4726 8 our -PRON- PRP$ cord-010092-uftc8inx 4726 9 centre centre NN cord-010092-uftc8inx 4726 10 , , , cord-010092-uftc8inx 4726 11 295 295 CD cord-010092-uftc8inx 4726 12 transfusions transfusion NNS cord-010092-uftc8inx 4726 13 were be VBD cord-010092-uftc8inx 4726 14 prospectively prospectively RB cord-010092-uftc8inx 4726 15 followed follow VBN cord-010092-uftc8inx 4726 16 up up RP cord-010092-uftc8inx 4726 17 with with IN cord-010092-uftc8inx 4726 18 a a DT cord-010092-uftc8inx 4726 19 structured structured JJ cord-010092-uftc8inx 4726 20 checklist checklist NN cord-010092-uftc8inx 4726 21 . . . cord-010092-uftc8inx 4727 1 The the DT cord-010092-uftc8inx 4727 2 quality quality NN cord-010092-uftc8inx 4727 3 indicators indicator NNS cord-010092-uftc8inx 4727 4 used use VBN cord-010092-uftc8inx 4727 5 were be VBD cord-010092-uftc8inx 4727 6 ( ( -LRB- cord-010092-uftc8inx 4727 7 i i NN cord-010092-uftc8inx 4727 8 ) ) -RRB- cord-010092-uftc8inx 4727 9 Verification verification NN cord-010092-uftc8inx 4727 10 of of IN cord-010092-uftc8inx 4727 11 blood blood NN cord-010092-uftc8inx 4727 12 components component NNS cord-010092-uftc8inx 4727 13 prior prior RB cord-010092-uftc8inx 4727 14 to to IN cord-010092-uftc8inx 4727 15 transfusion transfusion NN cord-010092-uftc8inx 4728 1 ( ( -LRB- cord-010092-uftc8inx 4728 2 ii)Initiation ii)initiation NN cord-010092-uftc8inx 4728 3 of of IN cord-010092-uftc8inx 4728 4 transfusion transfusion NN cord-010092-uftc8inx 4728 5 within within IN cord-010092-uftc8inx 4728 6 30 30 CD cord-010092-uftc8inx 4728 7 min min NN cord-010092-uftc8inx 4728 8 of of IN cord-010092-uftc8inx 4728 9 release release NN cord-010092-uftc8inx 4728 10 from from IN cord-010092-uftc8inx 4728 11 the the DT cord-010092-uftc8inx 4728 12 blood blood NN cord-010092-uftc8inx 4728 13 bank bank NN cord-010092-uftc8inx 4728 14 ( ( -LRB- cord-010092-uftc8inx 4728 15 iii iii NN cord-010092-uftc8inx 4728 16 ) ) -RRB- cord-010092-uftc8inx 4729 1 Close close JJ cord-010092-uftc8inx 4729 2 observation observation NN cord-010092-uftc8inx 4729 3 of of IN cord-010092-uftc8inx 4729 4 transfusions transfusion NNS cord-010092-uftc8inx 4729 5 for for IN cord-010092-uftc8inx 4729 6 the the DT cord-010092-uftc8inx 4729 7 first first JJ cord-010092-uftc8inx 4729 8 15 15 CD cord-010092-uftc8inx 4729 9 min min NN cord-010092-uftc8inx 4729 10 ( ( -LRB- cord-010092-uftc8inx 4729 11 iv)Completion iv)completion NN cord-010092-uftc8inx 4729 12 of of IN cord-010092-uftc8inx 4729 13 transfusion transfusion NN cord-010092-uftc8inx 4729 14 within within IN cord-010092-uftc8inx 4729 15 the the DT cord-010092-uftc8inx 4729 16 right right JJ cord-010092-uftc8inx 4729 17 time time NN cord-010092-uftc8inx 4729 18 frame frame NN cord-010092-uftc8inx 4729 19 for for IN cord-010092-uftc8inx 4729 20 each each DT cord-010092-uftc8inx 4729 21 component component NN cord-010092-uftc8inx 4729 22 . . . cord-010092-uftc8inx 4730 1 As as IN cord-010092-uftc8inx 4730 2 a a DT cord-010092-uftc8inx 4730 3 corrective corrective JJ cord-010092-uftc8inx 4730 4 measure measure NN cord-010092-uftc8inx 4730 5 , , , cord-010092-uftc8inx 4730 6 a a DT cord-010092-uftc8inx 4730 7 Transfusion transfusion NN cord-010092-uftc8inx 4730 8 monitoring monitoring NN cord-010092-uftc8inx 4730 9 format format NN cord-010092-uftc8inx 4730 10 was be VBD cord-010092-uftc8inx 4730 11 designed design VBN cord-010092-uftc8inx 4730 12 which which WDT cord-010092-uftc8inx 4730 13 was be VBD cord-010092-uftc8inx 4730 14 distributed distribute VBN cord-010092-uftc8inx 4730 15 in in IN cord-010092-uftc8inx 4730 16 every every DT cord-010092-uftc8inx 4730 17 ward ward NN cord-010092-uftc8inx 4730 18 and and CC cord-010092-uftc8inx 4730 19 the the DT cord-010092-uftc8inx 4730 20 nursing nursing NN cord-010092-uftc8inx 4730 21 officers officer NNS cord-010092-uftc8inx 4730 22 were be VBD cord-010092-uftc8inx 4730 23 informed inform VBN cord-010092-uftc8inx 4730 24 to to TO cord-010092-uftc8inx 4730 25 monitor monitor VB cord-010092-uftc8inx 4730 26 and and CC cord-010092-uftc8inx 4730 27 document document NN cord-010092-uftc8inx 4730 28 transfusions transfusion NNS cord-010092-uftc8inx 4730 29 using use VBG cord-010092-uftc8inx 4730 30 that that DT cord-010092-uftc8inx 4730 31 . . . cord-010092-uftc8inx 4731 1 In in IN cord-010092-uftc8inx 4731 2 addition addition NN cord-010092-uftc8inx 4731 3 , , , cord-010092-uftc8inx 4731 4 the the DT cord-010092-uftc8inx 4731 5 blood blood NN cord-010092-uftc8inx 4731 6 bank bank NN cord-010092-uftc8inx 4731 7 staff staff NN cord-010092-uftc8inx 4731 8 was be VBD cord-010092-uftc8inx 4731 9 made make VBN cord-010092-uftc8inx 4731 10 to to TO cord-010092-uftc8inx 4731 11 call call VB cord-010092-uftc8inx 4731 12 up up RP cord-010092-uftc8inx 4731 13 the the DT cord-010092-uftc8inx 4731 14 wards ward NNS cord-010092-uftc8inx 4731 15 and and CC cord-010092-uftc8inx 4731 16 ensure ensure VB cord-010092-uftc8inx 4731 17 that that IN cord-010092-uftc8inx 4731 18 the the DT cord-010092-uftc8inx 4731 19 transfusions transfusion NNS cord-010092-uftc8inx 4731 20 of of IN cord-010092-uftc8inx 4731 21 every every DT cord-010092-uftc8inx 4731 22 component component NN cord-010092-uftc8inx 4731 23 had have VBD cord-010092-uftc8inx 4731 24 been be VBN cord-010092-uftc8inx 4731 25 initiated initiate VBN cord-010092-uftc8inx 4731 26 within within IN cord-010092-uftc8inx 4731 27 30 30 CD cord-010092-uftc8inx 4731 28 min min NN cord-010092-uftc8inx 4731 29 of of IN cord-010092-uftc8inx 4731 30 issue issue NN cord-010092-uftc8inx 4731 31 . . . cord-010092-uftc8inx 4732 1 Transfusion transfusion NN cord-010092-uftc8inx 4732 2 practices practice NNS cord-010092-uftc8inx 4732 3 were be VBD cord-010092-uftc8inx 4732 4 once once RB cord-010092-uftc8inx 4732 5 again again RB cord-010092-uftc8inx 4732 6 monitored monitor VBN cord-010092-uftc8inx 4732 7 by by IN cord-010092-uftc8inx 4732 8 following follow VBG cord-010092-uftc8inx 4732 9 up up RP cord-010092-uftc8inx 4732 10 306 306 CD cord-010092-uftc8inx 4732 11 transfusions transfusion NNS cord-010092-uftc8inx 4732 12 using use VBG cord-010092-uftc8inx 4732 13 the the DT cord-010092-uftc8inx 4732 14 same same JJ cord-010092-uftc8inx 4732 15 quality quality NN cord-010092-uftc8inx 4732 16 indicators indicator NNS cord-010092-uftc8inx 4732 17 . . . cord-010092-uftc8inx 4733 1 Results result NNS cord-010092-uftc8inx 4733 2 : : : cord-010092-uftc8inx 4734 1 There there EX cord-010092-uftc8inx 4734 2 was be VBD cord-010092-uftc8inx 4734 3 significant significant JJ cord-010092-uftc8inx 4734 4 difference difference NN cord-010092-uftc8inx 4734 5 in in IN cord-010092-uftc8inx 4734 6 all all PDT cord-010092-uftc8inx 4734 7 the the DT cord-010092-uftc8inx 4734 8 four four CD cord-010092-uftc8inx 4734 9 variables variable NNS cord-010092-uftc8inx 4734 10 between between IN cord-010092-uftc8inx 4734 11 the the DT cord-010092-uftc8inx 4734 12 two two CD cord-010092-uftc8inx 4734 13 phases phase NNS cord-010092-uftc8inx 4734 14 . . . cord-010092-uftc8inx 4735 1 57.3 57.3 CD cord-010092-uftc8inx 4735 2 % % NN cord-010092-uftc8inx 4735 3 transfusions transfusion NNS cord-010092-uftc8inx 4735 4 were be VBD cord-010092-uftc8inx 4735 5 verified verify VBN cord-010092-uftc8inx 4735 6 in in IN cord-010092-uftc8inx 4735 7 Phase phase NN cord-010092-uftc8inx 4735 8 I -PRON- PRP cord-010092-uftc8inx 4735 9 while while IN cord-010092-uftc8inx 4735 10 73.6 73.6 CD cord-010092-uftc8inx 4735 11 % % NN cord-010092-uftc8inx 4735 12 were be VBD cord-010092-uftc8inx 4735 13 verified verify VBN cord-010092-uftc8inx 4735 14 in in IN cord-010092-uftc8inx 4735 15 Phase Phase NNP cord-010092-uftc8inx 4735 16 II II NNP cord-010092-uftc8inx 4735 17 ( ( -LRB- cord-010092-uftc8inx 4735 18 P p NN cord-010092-uftc8inx 4735 19 < < XX cord-010092-uftc8inx 4735 20 0.001 0.001 CD cord-010092-uftc8inx 4735 21 ) ) -RRB- cord-010092-uftc8inx 4735 22 . . . cord-010092-uftc8inx 4736 1 69.5 69.5 CD cord-010092-uftc8inx 4736 2 % % NN cord-010092-uftc8inx 4736 3 transfusions transfusion NNS cord-010092-uftc8inx 4736 4 were be VBD cord-010092-uftc8inx 4736 5 started start VBN cord-010092-uftc8inx 4736 6 within within IN cord-010092-uftc8inx 4736 7 half half PDT cord-010092-uftc8inx 4736 8 an an DT cord-010092-uftc8inx 4736 9 hour hour NN cord-010092-uftc8inx 4736 10 of of IN cord-010092-uftc8inx 4736 11 issue issue NN cord-010092-uftc8inx 4736 12 while while IN cord-010092-uftc8inx 4736 13 in in IN cord-010092-uftc8inx 4736 14 the the DT cord-010092-uftc8inx 4736 15 second second JJ cord-010092-uftc8inx 4736 16 phase phase NN cord-010092-uftc8inx 4736 17 , , , cord-010092-uftc8inx 4736 18 it -PRON- PRP cord-010092-uftc8inx 4736 19 rose rise VBD cord-010092-uftc8inx 4736 20 to to IN cord-010092-uftc8inx 4736 21 83.1 83.1 CD cord-010092-uftc8inx 4736 22 % % NN cord-010092-uftc8inx 4736 23 ( ( -LRB- cord-010092-uftc8inx 4736 24 P p NN cord-010092-uftc8inx 4736 25 < < XX cord-010092-uftc8inx 4736 26 0.001 0.001 CD cord-010092-uftc8inx 4736 27 ) ) -RRB- cord-010092-uftc8inx 4736 28 . . . cord-010092-uftc8inx 4737 1 47.8 47.8 CD cord-010092-uftc8inx 4737 2 % % NN cord-010092-uftc8inx 4737 3 transfusions transfusion NNS cord-010092-uftc8inx 4737 4 were be VBD cord-010092-uftc8inx 4737 5 observed observe VBN cord-010092-uftc8inx 4737 6 in in IN cord-010092-uftc8inx 4737 7 the the DT cord-010092-uftc8inx 4737 8 first first JJ cord-010092-uftc8inx 4737 9 15 15 CD cord-010092-uftc8inx 4737 10 min min NN cord-010092-uftc8inx 4737 11 in in IN cord-010092-uftc8inx 4737 12 Phase phase NN cord-010092-uftc8inx 4737 13 I -PRON- PRP cord-010092-uftc8inx 4737 14 and and CC cord-010092-uftc8inx 4737 15 88.6 88.6 CD cord-010092-uftc8inx 4737 16 % % NN cord-010092-uftc8inx 4737 17 were be VBD cord-010092-uftc8inx 4737 18 observed observe VBN cord-010092-uftc8inx 4737 19 in in IN cord-010092-uftc8inx 4737 20 the the DT cord-010092-uftc8inx 4737 21 second second JJ cord-010092-uftc8inx 4737 22 phase phase NN cord-010092-uftc8inx 4737 23 ( ( -LRB- cord-010092-uftc8inx 4737 24 P p NN cord-010092-uftc8inx 4737 25 < < XX cord-010092-uftc8inx 4737 26 0.001 0.001 CD cord-010092-uftc8inx 4737 27 ) ) -RRB- cord-010092-uftc8inx 4737 28 . . . cord-010092-uftc8inx 4738 1 In in IN cord-010092-uftc8inx 4738 2 Phase phase NN cord-010092-uftc8inx 4738 3 I -PRON- PRP cord-010092-uftc8inx 4738 4 , , , cord-010092-uftc8inx 4738 5 54.6 54.6 CD cord-010092-uftc8inx 4738 6 % % NN cord-010092-uftc8inx 4738 7 transfusions transfusion NNS cord-010092-uftc8inx 4738 8 were be VBD cord-010092-uftc8inx 4738 9 completed complete VBN cord-010092-uftc8inx 4738 10 within within IN cord-010092-uftc8inx 4738 11 right right JJ cord-010092-uftc8inx 4738 12 time time NN cord-010092-uftc8inx 4738 13 while while IN cord-010092-uftc8inx 4738 14 the the DT cord-010092-uftc8inx 4738 15 same same JJ cord-010092-uftc8inx 4738 16 in in IN cord-010092-uftc8inx 4738 17 Phase Phase NNP cord-010092-uftc8inx 4738 18 II II NNP cord-010092-uftc8inx 4738 19 was be VBD cord-010092-uftc8inx 4738 20 73.9 73.9 CD cord-010092-uftc8inx 4738 21 % % NN cord-010092-uftc8inx 4738 22 ( ( -LRB- cord-010092-uftc8inx 4738 23 P p NN cord-010092-uftc8inx 4738 24 < < XX cord-010092-uftc8inx 4738 25 0.001 0.001 CD cord-010092-uftc8inx 4738 26 ) ) -RRB- cord-010092-uftc8inx 4738 27 . . . cord-010092-uftc8inx 4739 1 Summary Summary NNP cord-010092-uftc8inx 4739 2 / / SYM cord-010092-uftc8inx 4739 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 4739 4 : : : cord-010092-uftc8inx 4740 1 We -PRON- PRP cord-010092-uftc8inx 4740 2 recommend recommend VBP cord-010092-uftc8inx 4740 3 the the DT cord-010092-uftc8inx 4740 4 following follow VBG cord-010092-uftc8inx 4740 5 as as IN cord-010092-uftc8inx 4740 6 quality quality NN cord-010092-uftc8inx 4740 7 indicators indicator NNS cord-010092-uftc8inx 4740 8 for for IN cord-010092-uftc8inx 4740 9 bedside bedside JJ cord-010092-uftc8inx 4740 10 transfusion transfusion NN cord-010092-uftc8inx 4740 11 practices practice NNS cord-010092-uftc8inx 4740 12 : : : cord-010092-uftc8inx 4741 1 Background background NN cord-010092-uftc8inx 4741 2 : : : cord-010092-uftc8inx 4742 1 Antibody antibody NN cord-010092-uftc8inx 4742 2 titration titration NN cord-010092-uftc8inx 4742 3 consists consist VBZ cord-010092-uftc8inx 4742 4 in in IN cord-010092-uftc8inx 4742 5 performing perform VBG cord-010092-uftc8inx 4742 6 antibody antibody NN cord-010092-uftc8inx 4742 7 detection detection NN cord-010092-uftc8inx 4742 8 with with IN cord-010092-uftc8inx 4742 9 selected select VBN cord-010092-uftc8inx 4742 10 red red JJ cord-010092-uftc8inx 4742 11 cells cell NNS cord-010092-uftc8inx 4742 12 of of IN cord-010092-uftc8inx 4742 13 different different JJ cord-010092-uftc8inx 4742 14 sample sample NN cord-010092-uftc8inx 4742 15 dilutions dilution NNS cord-010092-uftc8inx 4742 16 . . . cord-010092-uftc8inx 4743 1 The the DT cord-010092-uftc8inx 4743 2 titer titer NN cord-010092-uftc8inx 4743 3 is be VBZ cord-010092-uftc8inx 4743 4 reported report VBN cord-010092-uftc8inx 4743 5 as as IN cord-010092-uftc8inx 4743 6 the the DT cord-010092-uftc8inx 4743 7 reciprocal reciprocal NN cord-010092-uftc8inx 4743 8 of of IN cord-010092-uftc8inx 4743 9 the the DT cord-010092-uftc8inx 4743 10 highest high JJS cord-010092-uftc8inx 4743 11 dilution dilution NN cord-010092-uftc8inx 4743 12 that that WDT cord-010092-uftc8inx 4743 13 induces induce VBZ cord-010092-uftc8inx 4743 14 macroscopic macroscopic JJ cord-010092-uftc8inx 4743 15 agglutination agglutination NN cord-010092-uftc8inx 4743 16 . . . cord-010092-uftc8inx 4744 1 The the DT cord-010092-uftc8inx 4744 2 usual usual JJ cord-010092-uftc8inx 4744 3 applications application NNS cord-010092-uftc8inx 4744 4 of of IN cord-010092-uftc8inx 4744 5 titration titration NN cord-010092-uftc8inx 4744 6 are be VBP cord-010092-uftc8inx 4744 7 prenatal prenatal JJ cord-010092-uftc8inx 4744 8 studies study NNS cord-010092-uftc8inx 4744 9 and and CC cord-010092-uftc8inx 4744 10 complex complex JJ cord-010092-uftc8inx 4744 11 antibodies antibody NNS cord-010092-uftc8inx 4744 12 identification identification NN cord-010092-uftc8inx 4744 13 . . . cord-010092-uftc8inx 4745 1 Some some DT cord-010092-uftc8inx 4745 2 publications publication NNS cord-010092-uftc8inx 4745 3 have have VBP cord-010092-uftc8inx 4745 4 demonstrated demonstrate VBN cord-010092-uftc8inx 4745 5 that that IN cord-010092-uftc8inx 4745 6 more more JJR cord-010092-uftc8inx 4745 7 variation variation NN cord-010092-uftc8inx 4745 8 in in IN cord-010092-uftc8inx 4745 9 antibody antibody NN cord-010092-uftc8inx 4745 10 titer titer NN cord-010092-uftc8inx 4745 11 and and CC cord-010092-uftc8inx 4745 12 titration titration NN cord-010092-uftc8inx 4745 13 score score NN cord-010092-uftc8inx 4745 14 are be VBP cord-010092-uftc8inx 4745 15 noted note VBN cord-010092-uftc8inx 4745 16 upon upon IN cord-010092-uftc8inx 4745 17 repeat repeat NN cord-010092-uftc8inx 4745 18 testing testing NN cord-010092-uftc8inx 4745 19 of of IN cord-010092-uftc8inx 4745 20 the the DT cord-010092-uftc8inx 4745 21 same same JJ cord-010092-uftc8inx 4745 22 sample sample NN cord-010092-uftc8inx 4745 23 when when WRB cord-010092-uftc8inx 4745 24 testing testing NN cord-010092-uftc8inx 4745 25 was be VBD cord-010092-uftc8inx 4745 26 performed perform VBN cord-010092-uftc8inx 4745 27 in in IN cord-010092-uftc8inx 4745 28 tubes tube NNS cord-010092-uftc8inx 4745 29 as as IN cord-010092-uftc8inx 4745 30 compared compare VBN cord-010092-uftc8inx 4745 31 to to TO cord-010092-uftc8inx 4745 32 repeat repeat VB cord-010092-uftc8inx 4745 33 testing testing NN cord-010092-uftc8inx 4745 34 in in IN cord-010092-uftc8inx 4745 35 gel gel NN cord-010092-uftc8inx 4745 36 . . . cord-010092-uftc8inx 4746 1 Aims aim VBZ cord-010092-uftc8inx 4746 2 : : : cord-010092-uftc8inx 4746 3 To to TO cord-010092-uftc8inx 4746 4 evaluate evaluate VB cord-010092-uftc8inx 4746 5 the the DT cord-010092-uftc8inx 4746 6 efficacy efficacy NN cord-010092-uftc8inx 4746 7 of of IN cord-010092-uftc8inx 4746 8 automated automate VBN cord-010092-uftc8inx 4746 9 antibody antibody NN cord-010092-uftc8inx 4746 10 titration titration NN cord-010092-uftc8inx 4746 11 versus versus IN cord-010092-uftc8inx 4746 12 manual manual JJ cord-010092-uftc8inx 4746 13 method method NN cord-010092-uftc8inx 4746 14 by by IN cord-010092-uftc8inx 4746 15 using use VBG cord-010092-uftc8inx 4746 16 gel gel NN cord-010092-uftc8inx 4746 17 microcolumn microcolumn NN cord-010092-uftc8inx 4746 18 technology technology NN cord-010092-uftc8inx 4746 19 . . . cord-010092-uftc8inx 4747 1 Methods method NNS cord-010092-uftc8inx 4747 2 : : : cord-010092-uftc8inx 4747 3 EDTA edta NN cord-010092-uftc8inx 4747 4 - - HYPH cord-010092-uftc8inx 4747 5 anticoagulated anticoagulate VBN cord-010092-uftc8inx 4747 6 whole whole JJ cord-010092-uftc8inx 4747 7 blood blood NN cord-010092-uftc8inx 4747 8 donors donor NNS cord-010092-uftc8inx 4747 9 ' ' POS cord-010092-uftc8inx 4747 10 and and CC cord-010092-uftc8inx 4747 11 plasma plasma NN cord-010092-uftc8inx 4747 12 frozen frozen JJ cord-010092-uftc8inx 4747 13 samples sample NNS cord-010092-uftc8inx 4747 14 containing contain VBG cord-010092-uftc8inx 4747 15 a a DT cord-010092-uftc8inx 4747 16 known know VBN cord-010092-uftc8inx 4747 17 irregular irregular JJ cord-010092-uftc8inx 4747 18 ( ( -LRB- cord-010092-uftc8inx 4747 19 Rh Rh NNP cord-010092-uftc8inx 4747 20 , , , cord-010092-uftc8inx 4747 21 Kidd Kidd NNP cord-010092-uftc8inx 4747 22 , , , cord-010092-uftc8inx 4747 23 Duffy Duffy NNP cord-010092-uftc8inx 4747 24 , , , cord-010092-uftc8inx 4747 25 MNS MNS NNP cord-010092-uftc8inx 4747 26 , , , cord-010092-uftc8inx 4747 27 etc etc FW cord-010092-uftc8inx 4747 28 . . . cord-010092-uftc8inx 4747 29 ) ) -RRB- cord-010092-uftc8inx 4747 30 and and CC cord-010092-uftc8inx 4747 31 regular regular JJ cord-010092-uftc8inx 4747 32 ( ( -LRB- cord-010092-uftc8inx 4747 33 A1 A1 NNP cord-010092-uftc8inx 4747 34 & & CC cord-010092-uftc8inx 4747 35 B B NNP cord-010092-uftc8inx 4747 36 ) ) -RRB- cord-010092-uftc8inx 4747 37 antibodies antibody NNS cord-010092-uftc8inx 4747 38 were be VBD cord-010092-uftc8inx 4747 39 selected select VBN cord-010092-uftc8inx 4747 40 . . . cord-010092-uftc8inx 4748 1 The the DT cord-010092-uftc8inx 4748 2 titers titer NNS cord-010092-uftc8inx 4748 3 of of IN cord-010092-uftc8inx 4748 4 126 126 CD cord-010092-uftc8inx 4748 5 samples sample NNS cord-010092-uftc8inx 4748 6 were be VBD cord-010092-uftc8inx 4748 7 determined determine VBN cord-010092-uftc8inx 4748 8 in in IN cord-010092-uftc8inx 4748 9 parallel parallel NN cord-010092-uftc8inx 4748 10 by by IN cord-010092-uftc8inx 4748 11 using use VBG cord-010092-uftc8inx 4748 12 Grifols Grifols NNP cord-010092-uftc8inx 4748 13 analyzers analyzer NNS cord-010092-uftc8inx 4748 14 ( ( -LRB- cord-010092-uftc8inx 4748 15 Erytra Erytra NNP cord-010092-uftc8inx 4748 16 and and CC cord-010092-uftc8inx 4748 17 Erytra Erytra NNP cord-010092-uftc8inx 4748 18 Eflexis Eflexis NNP cord-010092-uftc8inx 4748 19 ) ) -RRB- cord-010092-uftc8inx 4748 20 and and CC cord-010092-uftc8inx 4748 21 compared compare VBN cord-010092-uftc8inx 4748 22 versus versus IN cord-010092-uftc8inx 4748 23 Grifols Grifols NNP cord-010092-uftc8inx 4748 24 Gel Gel NNP cord-010092-uftc8inx 4748 25 manual manual JJ cord-010092-uftc8inx 4748 26 method method NN cord-010092-uftc8inx 4748 27 by by IN cord-010092-uftc8inx 4748 28 using use VBG cord-010092-uftc8inx 4748 29 Grifols Grifols NNP cord-010092-uftc8inx 4748 30 Gel Gel NNP cord-010092-uftc8inx 4748 31 microcolumn microcolumn NN cord-010092-uftc8inx 4748 32 technology technology NN cord-010092-uftc8inx 4748 33 and and CC cord-010092-uftc8inx 4748 34 Grifols Grifols NNP cord-010092-uftc8inx 4748 35 red red JJ cord-010092-uftc8inx 4748 36 blood blood NN cord-010092-uftc8inx 4748 37 cell cell NN cord-010092-uftc8inx 4748 38 reagents reagent NNS cord-010092-uftc8inx 4748 39 . . . cord-010092-uftc8inx 4749 1 Sixty sixty CD cord-010092-uftc8inx 4749 2 of of IN cord-010092-uftc8inx 4749 3 these these DT cord-010092-uftc8inx 4749 4 also also RB cord-010092-uftc8inx 4749 5 processed process VBN cord-010092-uftc8inx 4749 6 in in IN cord-010092-uftc8inx 4749 7 parallel parallel NN cord-010092-uftc8inx 4749 8 in in IN cord-010092-uftc8inx 4749 9 Erytra Erytra NNP cord-010092-uftc8inx 4749 10 and and CC cord-010092-uftc8inx 4749 11 Erytra Erytra NNP cord-010092-uftc8inx 4749 12 Eflexis Eflexis NNP cord-010092-uftc8inx 4749 13 analyzers analyzer NNS cord-010092-uftc8inx 4749 14 for for IN cord-010092-uftc8inx 4749 15 comparison comparison NN cord-010092-uftc8inx 4749 16 . . . cord-010092-uftc8inx 4750 1 For for IN cord-010092-uftc8inx 4750 2 the the DT cord-010092-uftc8inx 4750 3 precision precision NN cord-010092-uftc8inx 4750 4 study study NN cord-010092-uftc8inx 4750 5 , , , cord-010092-uftc8inx 4750 6 12 12 CD cord-010092-uftc8inx 4750 7 of of IN cord-010092-uftc8inx 4750 8 these these DT cord-010092-uftc8inx 4750 9 samples sample NNS cord-010092-uftc8inx 4750 10 were be VBD cord-010092-uftc8inx 4750 11 tested test VBN cord-010092-uftc8inx 4750 12 in in IN cord-010092-uftc8inx 4750 13 the the DT cord-010092-uftc8inx 4750 14 2 2 CD cord-010092-uftc8inx 4750 15 automated automate VBN cord-010092-uftc8inx 4750 16 systems system NNS cord-010092-uftc8inx 4750 17 for for IN cord-010092-uftc8inx 4750 18 5 5 CD cord-010092-uftc8inx 4750 19 times time NNS cord-010092-uftc8inx 4750 20 ( ( -LRB- cord-010092-uftc8inx 4750 21 120 120 CD cord-010092-uftc8inx 4750 22 datapoints datapoint NNS cord-010092-uftc8inx 4750 23 for for IN cord-010092-uftc8inx 4750 24 each each DT cord-010092-uftc8inx 4750 25 analyzer analyzer NN cord-010092-uftc8inx 4750 26 ) ) -RRB- cord-010092-uftc8inx 4750 27 on on IN cord-010092-uftc8inx 4750 28 different different JJ cord-010092-uftc8inx 4750 29 testing testing NN cord-010092-uftc8inx 4750 30 days day NNS cord-010092-uftc8inx 4750 31 . . . cord-010092-uftc8inx 4751 1 The the DT cord-010092-uftc8inx 4751 2 hands hand NNS cord-010092-uftc8inx 4751 3 - - HYPH cord-010092-uftc8inx 4751 4 on on RP cord-010092-uftc8inx 4751 5 ( ( -LRB- cord-010092-uftc8inx 4751 6 manual manual JJ cord-010092-uftc8inx 4751 7 intervention intervention NN cord-010092-uftc8inx 4751 8 ) ) -RRB- cord-010092-uftc8inx 4751 9 average average JJ cord-010092-uftc8inx 4751 10 time time NN cord-010092-uftc8inx 4751 11 required require VBN cord-010092-uftc8inx 4751 12 to to TO cord-010092-uftc8inx 4751 13 complete complete VB cord-010092-uftc8inx 4751 14 a a DT cord-010092-uftc8inx 4751 15 titration titration NN cord-010092-uftc8inx 4751 16 was be VBD cord-010092-uftc8inx 4751 17 measured measure VBN cord-010092-uftc8inx 4751 18 ( ( -LRB- cord-010092-uftc8inx 4751 19 3 3 CD cord-010092-uftc8inx 4751 20 expert expert NN cord-010092-uftc8inx 4751 21 technicians technician NNS cord-010092-uftc8inx 4751 22 ) ) -RRB- cord-010092-uftc8inx 4751 23 in in IN cord-010092-uftc8inx 4751 24 2 2 CD cord-010092-uftc8inx 4751 25 different different JJ cord-010092-uftc8inx 4751 26 sample sample NN cord-010092-uftc8inx 4751 27 workload workload NN cord-010092-uftc8inx 4751 28 ( ( -LRB- cord-010092-uftc8inx 4751 29 1 1 CD cord-010092-uftc8inx 4751 30 and and CC cord-010092-uftc8inx 4751 31 10 10 CD cord-010092-uftc8inx 4751 32 samples sample NNS cord-010092-uftc8inx 4751 33 testing test VBG cord-010092-uftc8inx 4751 34 ) ) -RRB- cord-010092-uftc8inx 4751 35 . . . cord-010092-uftc8inx 4752 1 These these DT cord-010092-uftc8inx 4752 2 results result NNS cord-010092-uftc8inx 4752 3 were be VBD cord-010092-uftc8inx 4752 4 compared compare VBN cord-010092-uftc8inx 4752 5 with with IN cord-010092-uftc8inx 4752 6 the the DT cord-010092-uftc8inx 4752 7 same same JJ cord-010092-uftc8inx 4752 8 number number NN cord-010092-uftc8inx 4752 9 of of IN cord-010092-uftc8inx 4752 10 independent independent JJ cord-010092-uftc8inx 4752 11 titrations titration NNS cord-010092-uftc8inx 4752 12 performed perform VBN cord-010092-uftc8inx 4752 13 in in IN cord-010092-uftc8inx 4752 14 Grifols Grifols NNP cord-010092-uftc8inx 4752 15 analyzers analyzer NNS cord-010092-uftc8inx 4752 16 . . . cord-010092-uftc8inx 4753 1 For for IN cord-010092-uftc8inx 4753 2 the the DT cord-010092-uftc8inx 4753 3 walk walk NN cord-010092-uftc8inx 4753 4 - - HYPH cord-010092-uftc8inx 4753 5 away away RP cord-010092-uftc8inx 4753 6 time time NN cord-010092-uftc8inx 4753 7 , , , cord-010092-uftc8inx 4753 8 2 2 CD cord-010092-uftc8inx 4753 9 different different JJ cord-010092-uftc8inx 4753 10 sample sample NN cord-010092-uftc8inx 4753 11 workload workload NN cord-010092-uftc8inx 4753 12 ( ( -LRB- cord-010092-uftc8inx 4753 13 1 1 CD cord-010092-uftc8inx 4753 14 and and CC cord-010092-uftc8inx 4753 15 10 10 CD cord-010092-uftc8inx 4753 16 samples sample NNS cord-010092-uftc8inx 4753 17 testing testing NN cord-010092-uftc8inx 4753 18 ) ) -RRB- cord-010092-uftc8inx 4753 19 were be VBD cord-010092-uftc8inx 4753 20 assessed assess VBN cord-010092-uftc8inx 4753 21 in in IN cord-010092-uftc8inx 4753 22 manual manual JJ cord-010092-uftc8inx 4753 23 method method NN cord-010092-uftc8inx 4753 24 ( ( -LRB- cord-010092-uftc8inx 4753 25 3 3 CD cord-010092-uftc8inx 4753 26 expert expert NN cord-010092-uftc8inx 4753 27 technicians technician NNS cord-010092-uftc8inx 4753 28 ) ) -RRB- cord-010092-uftc8inx 4753 29 and and CC cord-010092-uftc8inx 4753 30 compared compare VBN cord-010092-uftc8inx 4753 31 to to IN cord-010092-uftc8inx 4753 32 timings timing NNS cord-010092-uftc8inx 4753 33 obtained obtain VBN cord-010092-uftc8inx 4753 34 when when WRB cord-010092-uftc8inx 4753 35 reproduced reproduce VBN cord-010092-uftc8inx 4753 36 in in IN cord-010092-uftc8inx 4753 37 Grifols Grifols NNP cord-010092-uftc8inx 4753 38 analyzers analyzer NNS cord-010092-uftc8inx 4753 39 . . . cord-010092-uftc8inx 4754 1 Results result NNS cord-010092-uftc8inx 4754 2 provided provide VBN cord-010092-uftc8inx 4754 3 by by IN cord-010092-uftc8inx 4754 4 analyzers analyzer NNS cord-010092-uftc8inx 4754 5 were be VBD cord-010092-uftc8inx 4754 6 reviewed review VBN cord-010092-uftc8inx 4754 7 and and CC cord-010092-uftc8inx 4754 8 compared compare VBN cord-010092-uftc8inx 4754 9 to to IN cord-010092-uftc8inx 4754 10 manual manual JJ cord-010092-uftc8inx 4754 11 method method NN cord-010092-uftc8inx 4754 12 . . . cord-010092-uftc8inx 4755 1 Results result NNS cord-010092-uftc8inx 4755 2 : : : cord-010092-uftc8inx 4756 1 Titer titer NN cord-010092-uftc8inx 4756 2 obtained obtain VBN cord-010092-uftc8inx 4756 3 by by IN cord-010092-uftc8inx 4756 4 Erytra Erytra NNP cord-010092-uftc8inx 4756 5 or or CC cord-010092-uftc8inx 4756 6 Erytra Erytra NNP cord-010092-uftc8inx 4756 7 Eflexis Eflexis NNP cord-010092-uftc8inx 4756 8 was be VBD cord-010092-uftc8inx 4756 9 equivalent equivalent JJ cord-010092-uftc8inx 4756 10 to to IN cord-010092-uftc8inx 4756 11 the the DT cord-010092-uftc8inx 4756 12 titer titer NN cord-010092-uftc8inx 4756 13 obtained obtain VBN cord-010092-uftc8inx 4756 14 manually manually RB cord-010092-uftc8inx 4757 1 ( ( -LRB- cord-010092-uftc8inx 4757 2 differences difference NNS cord-010092-uftc8inx 4757 3 ≤ ≤ NNP cord-010092-uftc8inx 4757 4 1 1 CD cord-010092-uftc8inx 4757 5 titer titer NN cord-010092-uftc8inx 4757 6 : : : cord-010092-uftc8inx 4757 7 73 73 CD cord-010092-uftc8inx 4757 8 % % NN cord-010092-uftc8inx 4757 9 ≤0.5 ≤0.5 NNP cord-010092-uftc8inx 4757 10 titer titer NN cord-010092-uftc8inx 4757 11 ) ) -RRB- cord-010092-uftc8inx 4757 12 . . . cord-010092-uftc8inx 4758 1 The the DT cord-010092-uftc8inx 4758 2 results result NNS cord-010092-uftc8inx 4758 3 proved prove VBD cord-010092-uftc8inx 4758 4 that that IN cord-010092-uftc8inx 4758 5 both both DT cord-010092-uftc8inx 4758 6 instruments instrument NNS cord-010092-uftc8inx 4758 7 were be VBD cord-010092-uftc8inx 4758 8 equivalent equivalent JJ cord-010092-uftc8inx 4758 9 in in IN cord-010092-uftc8inx 4758 10 performing perform VBG cord-010092-uftc8inx 4758 11 titration titration NN cord-010092-uftc8inx 4758 12 ( ( -LRB- cord-010092-uftc8inx 4758 13 differences difference NNS cord-010092-uftc8inx 4758 14 ≤ ≤ NNP cord-010092-uftc8inx 4758 15 1 1 CD cord-010092-uftc8inx 4758 16 titer titer NN cord-010092-uftc8inx 4758 17 ; ; : cord-010092-uftc8inx 4758 18 85 85 CD cord-010092-uftc8inx 4758 19 % % NN cord-010092-uftc8inx 4758 20 ≤0.5 ≤0.5 NNP cord-010092-uftc8inx 4758 21 titer titer NN cord-010092-uftc8inx 4758 22 ) ) -RRB- cord-010092-uftc8inx 4758 23 . . . cord-010092-uftc8inx 4759 1 The the DT cord-010092-uftc8inx 4759 2 precision precision NN cord-010092-uftc8inx 4759 3 results result NNS cord-010092-uftc8inx 4759 4 showed show VBD cord-010092-uftc8inx 4759 5 no no DT cord-010092-uftc8inx 4759 6 difference difference NN cord-010092-uftc8inx 4759 7 between between IN cord-010092-uftc8inx 4759 8 titers titer NNS cord-010092-uftc8inx 4759 9 obtained obtain VBN cord-010092-uftc8inx 4759 10 through through IN cord-010092-uftc8inx 4759 11 the the DT cord-010092-uftc8inx 4759 12 100 100 CD cord-010092-uftc8inx 4759 13 % % NN cord-010092-uftc8inx 4759 14 of of IN cord-010092-uftc8inx 4759 15 the the DT cord-010092-uftc8inx 4759 16 runs run NNS cord-010092-uftc8inx 4759 17 performed perform VBN cord-010092-uftc8inx 4759 18 with with IN cord-010092-uftc8inx 4759 19 the the DT cord-010092-uftc8inx 4759 20 Grifols Grifols NNP cord-010092-uftc8inx 4759 21 analyzers analyzer NNS cord-010092-uftc8inx 4759 22 ( ( -LRB- cord-010092-uftc8inx 4760 1 differences difference NNS cord-010092-uftc8inx 4760 2 ≤ ≤ NNP cord-010092-uftc8inx 4760 3 1 1 CD cord-010092-uftc8inx 4760 4 titer titer NN cord-010092-uftc8inx 4760 5 : : : cord-010092-uftc8inx 4760 6 75 75 CD cord-010092-uftc8inx 4760 7 % % NN cord-010092-uftc8inx 4760 8 ≤0.5 ≤0.5 NNP cord-010092-uftc8inx 4760 9 titer titer NN cord-010092-uftc8inx 4760 10 ) ) -RRB- cord-010092-uftc8inx 4760 11 . . . cord-010092-uftc8inx 4761 1 The the DT cord-010092-uftc8inx 4761 2 manual manual JJ cord-010092-uftc8inx 4761 3 hands hand NNS cord-010092-uftc8inx 4761 4 - - HYPH cord-010092-uftc8inx 4761 5 on on RP cord-010092-uftc8inx 4761 6 in in IN cord-010092-uftc8inx 4761 7 automated automated JJ cord-010092-uftc8inx 4761 8 system system NN cord-010092-uftc8inx 4761 9 was be VBD cord-010092-uftc8inx 4761 10 reduced reduce VBN cord-010092-uftc8inx 4761 11 in in IN cord-010092-uftc8inx 4761 12 a a DT cord-010092-uftc8inx 4761 13 15 15 CD cord-010092-uftc8inx 4761 14 % % NN cord-010092-uftc8inx 4761 15 compared compare VBN cord-010092-uftc8inx 4761 16 to to IN cord-010092-uftc8inx 4761 17 manual manual JJ cord-010092-uftc8inx 4761 18 method method NN cord-010092-uftc8inx 4761 19 for for IN cord-010092-uftc8inx 4761 20 1 1 CD cord-010092-uftc8inx 4761 21 sample sample NN cord-010092-uftc8inx 4761 22 . . . cord-010092-uftc8inx 4762 1 When when WRB cord-010092-uftc8inx 4762 2 the the DT cord-010092-uftc8inx 4762 3 number number NN cord-010092-uftc8inx 4762 4 of of IN cord-010092-uftc8inx 4762 5 samples sample NNS cord-010092-uftc8inx 4762 6 was be VBD cord-010092-uftc8inx 4762 7 increased increase VBN cord-010092-uftc8inx 4762 8 ( ( -LRB- cord-010092-uftc8inx 4762 9 10 10 CD cord-010092-uftc8inx 4762 10 samples sample NNS cord-010092-uftc8inx 4762 11 ) ) -RRB- cord-010092-uftc8inx 4762 12 , , , cord-010092-uftc8inx 4762 13 the the DT cord-010092-uftc8inx 4762 14 difference difference NN cord-010092-uftc8inx 4762 15 in in IN cord-010092-uftc8inx 4762 16 hands hand NNS cord-010092-uftc8inx 4762 17 - - HYPH cord-010092-uftc8inx 4762 18 on on RP cord-010092-uftc8inx 4762 19 in in IN cord-010092-uftc8inx 4762 20 was be VBD cord-010092-uftc8inx 4762 21 even even RB cord-010092-uftc8inx 4762 22 more more RBR cord-010092-uftc8inx 4762 23 reduced reduce VBN cord-010092-uftc8inx 4762 24 ( ( -LRB- cord-010092-uftc8inx 4762 25 65 65 CD cord-010092-uftc8inx 4762 26 % % NN cord-010092-uftc8inx 4762 27 ) ) -RRB- cord-010092-uftc8inx 4762 28 . . . cord-010092-uftc8inx 4763 1 In in IN cord-010092-uftc8inx 4763 2 addition addition NN cord-010092-uftc8inx 4763 3 , , , cord-010092-uftc8inx 4763 4 the the DT cord-010092-uftc8inx 4763 5 walk walk NN cord-010092-uftc8inx 4763 6 - - HYPH cord-010092-uftc8inx 4763 7 away away NN cord-010092-uftc8inx 4763 8 was be VBD cord-010092-uftc8inx 4763 9 46 46 CD cord-010092-uftc8inx 4763 10 % % NN cord-010092-uftc8inx 4763 11 higher high JJR cord-010092-uftc8inx 4763 12 in in IN cord-010092-uftc8inx 4763 13 automated automate VBN cord-010092-uftc8inx 4763 14 system system NN cord-010092-uftc8inx 4763 15 compared compare VBN cord-010092-uftc8inx 4763 16 to to IN cord-010092-uftc8inx 4763 17 manual manual JJ cord-010092-uftc8inx 4763 18 method method NN cord-010092-uftc8inx 4763 19 . . . cord-010092-uftc8inx 4764 1 Furthermore furthermore RB cord-010092-uftc8inx 4764 2 , , , cord-010092-uftc8inx 4764 3 when when WRB cord-010092-uftc8inx 4764 4 the the DT cord-010092-uftc8inx 4764 5 number number NN cord-010092-uftc8inx 4764 6 of of IN cord-010092-uftc8inx 4764 7 samples sample NNS cord-010092-uftc8inx 4764 8 was be VBD cord-010092-uftc8inx 4764 9 increased increase VBN cord-010092-uftc8inx 4764 10 ( ( -LRB- cord-010092-uftc8inx 4764 11 10 10 CD cord-010092-uftc8inx 4764 12 samples sample NNS cord-010092-uftc8inx 4764 13 ) ) -RRB- cord-010092-uftc8inx 4764 14 , , , cord-010092-uftc8inx 4764 15 the the DT cord-010092-uftc8inx 4764 16 walk walk NN cord-010092-uftc8inx 4764 17 - - HYPH cord-010092-uftc8inx 4764 18 away away RP cord-010092-uftc8inx 4764 19 difference difference NN cord-010092-uftc8inx 4764 20 was be VBD cord-010092-uftc8inx 4764 21 increased increase VBN cord-010092-uftc8inx 4764 22 even even RB cord-010092-uftc8inx 4764 23 more more RBR cord-010092-uftc8inx 4764 24 ( ( -LRB- cord-010092-uftc8inx 4764 25 78 78 CD cord-010092-uftc8inx 4764 26 % % NN cord-010092-uftc8inx 4764 27 ) ) -RRB- cord-010092-uftc8inx 4764 28 . . . cord-010092-uftc8inx 4765 1 Finally finally RB cord-010092-uftc8inx 4765 2 , , , cord-010092-uftc8inx 4765 3 automated automated JJ cord-010092-uftc8inx 4765 4 system system NN cord-010092-uftc8inx 4765 5 software software NN cord-010092-uftc8inx 4765 6 demonstrated demonstrate VBD cord-010092-uftc8inx 4765 7 to to TO cord-010092-uftc8inx 4765 8 increase increase VB cord-010092-uftc8inx 4765 9 the the DT cord-010092-uftc8inx 4765 10 standardization standardization NN cord-010092-uftc8inx 4765 11 of of IN cord-010092-uftc8inx 4765 12 the the DT cord-010092-uftc8inx 4765 13 test test NN cord-010092-uftc8inx 4765 14 as as IN cord-010092-uftc8inx 4765 15 all all DT cord-010092-uftc8inx 4765 16 samples sample NNS cord-010092-uftc8inx 4765 17 , , , cord-010092-uftc8inx 4765 18 results result NNS cord-010092-uftc8inx 4765 19 and and CC cord-010092-uftc8inx 4765 20 reagents reagent NNS cord-010092-uftc8inx 4765 21 traceability traceability NN cord-010092-uftc8inx 4765 22 were be VBD cord-010092-uftc8inx 4765 23 automatically automatically RB cord-010092-uftc8inx 4765 24 managed manage VBN cord-010092-uftc8inx 4765 25 . . . cord-010092-uftc8inx 4766 1 Summary Summary NNP cord-010092-uftc8inx 4766 2 / / SYM cord-010092-uftc8inx 4766 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 4766 4 : : : cord-010092-uftc8inx 4767 1 Grifols Grifols NNP cord-010092-uftc8inx 4767 2 Gel Gel NNP cord-010092-uftc8inx 4767 3 System System NNP cord-010092-uftc8inx 4767 4 including include VBG cord-010092-uftc8inx 4767 5 Erytra Erytra NNP cord-010092-uftc8inx 4767 6 and and CC cord-010092-uftc8inx 4767 7 Erytra Erytra NNP cord-010092-uftc8inx 4767 8 Eflexis Eflexis NNP cord-010092-uftc8inx 4767 9 analyzers analyzer NNS cord-010092-uftc8inx 4767 10 provided provide VBD cord-010092-uftc8inx 4767 11 a a DT cord-010092-uftc8inx 4767 12 scalable scalable JJ cord-010092-uftc8inx 4767 13 and and CC cord-010092-uftc8inx 4767 14 efficient efficient JJ cord-010092-uftc8inx 4767 15 solution solution NN cord-010092-uftc8inx 4767 16 to to TO cord-010092-uftc8inx 4767 17 perform perform VB cord-010092-uftc8inx 4767 18 standardized standardized JJ cord-010092-uftc8inx 4767 19 titrations titration NNS cord-010092-uftc8inx 4767 20 in in IN cord-010092-uftc8inx 4767 21 the the DT cord-010092-uftc8inx 4767 22 immunohematology immunohematology NN cord-010092-uftc8inx 4767 23 lab lab NN cord-010092-uftc8inx 4767 24 . . . cord-010092-uftc8inx 4768 1 The the DT cord-010092-uftc8inx 4768 2 study study NN cord-010092-uftc8inx 4768 3 proved prove VBD cord-010092-uftc8inx 4768 4 that that IN cord-010092-uftc8inx 4768 5 using use VBG cord-010092-uftc8inx 4768 6 Grifols Grifols NNP cord-010092-uftc8inx 4768 7 Gel Gel NNP cord-010092-uftc8inx 4768 8 System System NNP cord-010092-uftc8inx 4768 9 , , , cord-010092-uftc8inx 4768 10 titrations titration NNS cord-010092-uftc8inx 4768 11 can can MD cord-010092-uftc8inx 4768 12 be be VB cord-010092-uftc8inx 4768 13 run run VBN cord-010092-uftc8inx 4768 14 in in IN cord-010092-uftc8inx 4768 15 an an DT cord-010092-uftc8inx 4768 16 automated automated JJ cord-010092-uftc8inx 4768 17 reliable reliable JJ cord-010092-uftc8inx 4768 18 way way NN cord-010092-uftc8inx 4768 19 ( ( -LRB- cord-010092-uftc8inx 4768 20 less less JJR cord-010092-uftc8inx 4768 21 than than IN cord-010092-uftc8inx 4768 22 one one CD cord-010092-uftc8inx 4768 23 - - HYPH cord-010092-uftc8inx 4768 24 fold fold VB cord-010092-uftc8inx 4768 25 differences difference NNS cord-010092-uftc8inx 4768 26 versus versus IN cord-010092-uftc8inx 4768 27 manual manual JJ cord-010092-uftc8inx 4768 28 gel gel NN cord-010092-uftc8inx 4768 29 ) ) -RRB- cord-010092-uftc8inx 4768 30 , , , cord-010092-uftc8inx 4768 31 thus thus RB cord-010092-uftc8inx 4768 32 reducing reduce VBG cord-010092-uftc8inx 4768 33 at at RB cord-010092-uftc8inx 4768 34 least least RBS cord-010092-uftc8inx 4768 35 15 15 CD cord-010092-uftc8inx 4768 36 % % NN cord-010092-uftc8inx 4768 37 the the DT cord-010092-uftc8inx 4768 38 hands hand NNS cord-010092-uftc8inx 4768 39 - - HYPH cord-010092-uftc8inx 4768 40 on on RP cord-010092-uftc8inx 4768 41 , , , cord-010092-uftc8inx 4768 42 increasing increase VBG cord-010092-uftc8inx 4768 43 at at RB cord-010092-uftc8inx 4768 44 least least RBS cord-010092-uftc8inx 4768 45 46 46 CD cord-010092-uftc8inx 4768 46 % % NN cord-010092-uftc8inx 4768 47 the the DT cord-010092-uftc8inx 4768 48 walk walk NN cord-010092-uftc8inx 4768 49 - - HYPH cord-010092-uftc8inx 4768 50 away away RB cord-010092-uftc8inx 4768 51 , , , cord-010092-uftc8inx 4768 52 rising rise VBG cord-010092-uftc8inx 4768 53 the the DT cord-010092-uftc8inx 4768 54 standardization standardization NN cord-010092-uftc8inx 4768 55 and and CC cord-010092-uftc8inx 4768 56 automating automate VBG cord-010092-uftc8inx 4768 57 all all DT cord-010092-uftc8inx 4768 58 testing test VBG cord-010092-uftc8inx 4768 59 traceability traceability NN cord-010092-uftc8inx 4768 60 . . . cord-010092-uftc8inx 4769 1 , , , cord-010092-uftc8inx 4769 2 and and CC cord-010092-uftc8inx 4769 3 fourth fourth JJ cord-010092-uftc8inx 4769 4 case case NN cord-010092-uftc8inx 4769 5 of of IN cord-010092-uftc8inx 4769 6 use use NN cord-010092-uftc8inx 4769 7 ( ( -LRB- cord-010092-uftc8inx 4769 8 Results result NNS cord-010092-uftc8inx 4769 9 ) ) -RRB- cord-010092-uftc8inx 4769 10 scenarios scenario NNS cord-010092-uftc8inx 4769 11 , , , cord-010092-uftc8inx 4769 12 tasks task NNS cord-010092-uftc8inx 4769 13 were be VBD cord-010092-uftc8inx 4769 14 considered consider VBN cord-010092-uftc8inx 4769 15 " " `` cord-010092-uftc8inx 4769 16 very very RB cord-010092-uftc8inx 4769 17 easy easy JJ cord-010092-uftc8inx 4769 18 " " '' cord-010092-uftc8inx 4769 19 by by IN cord-010092-uftc8inx 4769 20 30%>50 30%>50 CD cord-010092-uftc8inx 4769 21 % % NN cord-010092-uftc8inx 4769 22 of of IN cord-010092-uftc8inx 4769 23 users user NNS cord-010092-uftc8inx 4769 24 and and CC cord-010092-uftc8inx 4769 25 " " `` cord-010092-uftc8inx 4769 26 easy easy JJ cord-010092-uftc8inx 4769 27 " " '' cord-010092-uftc8inx 4769 28 and and CC cord-010092-uftc8inx 4769 29 by by IN cord-010092-uftc8inx 4769 30 50 50 CD cord-010092-uftc8inx 4769 31 - - SYM cord-010092-uftc8inx 4769 32 80 80 CD cord-010092-uftc8inx 4769 33 % % NN cord-010092-uftc8inx 4769 34 of of IN cord-010092-uftc8inx 4769 35 users user NNS cord-010092-uftc8inx 4769 36 ; ; : cord-010092-uftc8inx 4769 37 90%>100 90%>100 CD cord-010092-uftc8inx 4769 38 % % NN cord-010092-uftc8inx 4769 39 of of IN cord-010092-uftc8inx 4769 40 the the DT cord-010092-uftc8inx 4769 41 users user NNS cord-010092-uftc8inx 4769 42 considered consider VBN cord-010092-uftc8inx 4769 43 " " `` cord-010092-uftc8inx 4769 44 sufficient sufficient JJ cord-010092-uftc8inx 4769 45 " " '' cord-010092-uftc8inx 4769 46 the the DT cord-010092-uftc8inx 4769 47 design design NN cord-010092-uftc8inx 4769 48 to to TO cord-010092-uftc8inx 4769 49 ease ease VB cord-010092-uftc8inx 4769 50 the the DT cord-010092-uftc8inx 4769 51 interaction interaction NN cord-010092-uftc8inx 4769 52 ; ; : cord-010092-uftc8inx 4769 53 and and CC cord-010092-uftc8inx 4769 54 60%>80 60%>80 CD cord-010092-uftc8inx 4769 55 % % NN cord-010092-uftc8inx 4769 56 of of IN cord-010092-uftc8inx 4769 57 users user NNS cord-010092-uftc8inx 4769 58 never never RB cord-010092-uftc8inx 4769 59 founding found VBG cord-010092-uftc8inx 4769 60 any any DT cord-010092-uftc8inx 4769 61 situation situation NN cord-010092-uftc8inx 4769 62 of of IN cord-010092-uftc8inx 4769 63 not not RB cord-010092-uftc8inx 4769 64 knowing know VBG cord-010092-uftc8inx 4769 65 how how WRB cord-010092-uftc8inx 4769 66 to to TO cord-010092-uftc8inx 4769 67 proceed proceed VB cord-010092-uftc8inx 4769 68 . . . cord-010092-uftc8inx 4770 1 For for IN cord-010092-uftc8inx 4770 2 the the DT cord-010092-uftc8inx 4770 3 fifth fifth JJ cord-010092-uftc8inx 4770 4 case case NN cord-010092-uftc8inx 4770 5 of of IN cord-010092-uftc8inx 4770 6 use use NN cord-010092-uftc8inx 4770 7 ( ( -LRB- cord-010092-uftc8inx 4770 8 User User NNP cord-010092-uftc8inx 4770 9 roles role NNS cord-010092-uftc8inx 4770 10 ) ) -RRB- cord-010092-uftc8inx 4770 11 , , , cord-010092-uftc8inx 4770 12 40 40 CD cord-010092-uftc8inx 4770 13 % % NN cord-010092-uftc8inx 4770 14 of of IN cord-010092-uftc8inx 4770 15 users user NNS cord-010092-uftc8inx 4770 16 considered consider VBN cord-010092-uftc8inx 4770 17 tasks task NNS cord-010092-uftc8inx 4770 18 " " `` cord-010092-uftc8inx 4770 19 very very RB cord-010092-uftc8inx 4770 20 easy easy JJ cord-010092-uftc8inx 4770 21 " " '' cord-010092-uftc8inx 4770 22 or or CC cord-010092-uftc8inx 4770 23 " " `` cord-010092-uftc8inx 4770 24 easy easy JJ cord-010092-uftc8inx 4770 25 " " '' cord-010092-uftc8inx 4770 26 ; ; : cord-010092-uftc8inx 4770 27 40 40 CD cord-010092-uftc8inx 4770 28 % % NN cord-010092-uftc8inx 4770 29 of of IN cord-010092-uftc8inx 4770 30 users user NNS cord-010092-uftc8inx 4770 31 considered consider VBN cord-010092-uftc8inx 4770 32 " " `` cord-010092-uftc8inx 4770 33 sufficient sufficient JJ cord-010092-uftc8inx 4770 34 " " '' cord-010092-uftc8inx 4770 35 the the DT cord-010092-uftc8inx 4770 36 design design NN cord-010092-uftc8inx 4770 37 to to TO cord-010092-uftc8inx 4770 38 ease ease VB cord-010092-uftc8inx 4770 39 the the DT cord-010092-uftc8inx 4770 40 interaction interaction NN cord-010092-uftc8inx 4770 41 ; ; : cord-010092-uftc8inx 4770 42 and and CC cord-010092-uftc8inx 4770 43 40 40 CD cord-010092-uftc8inx 4770 44 % % NN cord-010092-uftc8inx 4770 45 of of IN cord-010092-uftc8inx 4770 46 users user NNS cord-010092-uftc8inx 4770 47 never never RB cord-010092-uftc8inx 4770 48 found find VBD cord-010092-uftc8inx 4770 49 any any DT cord-010092-uftc8inx 4770 50 situation situation NN cord-010092-uftc8inx 4770 51 of of IN cord-010092-uftc8inx 4770 52 not not RB cord-010092-uftc8inx 4770 53 knowing know VBG cord-010092-uftc8inx 4770 54 how how WRB cord-010092-uftc8inx 4770 55 to to TO cord-010092-uftc8inx 4770 56 proceed proceed VB cord-010092-uftc8inx 4770 57 . . . cord-010092-uftc8inx 4771 1 For for IN cord-010092-uftc8inx 4771 2 the the DT cord-010092-uftc8inx 4771 3 sixth sixth JJ cord-010092-uftc8inx 4771 4 case case NN cord-010092-uftc8inx 4771 5 of of IN cord-010092-uftc8inx 4771 6 use use NN cord-010092-uftc8inx 4771 7 ( ( -LRB- cord-010092-uftc8inx 4771 8 Maintenance Maintenance NNP cord-010092-uftc8inx 4771 9 Plan Plan NNP cord-010092-uftc8inx 4771 10 ) ) -RRB- cord-010092-uftc8inx 4771 11 , , , cord-010092-uftc8inx 4771 12 100 100 CD cord-010092-uftc8inx 4771 13 % % NN cord-010092-uftc8inx 4771 14 of of IN cord-010092-uftc8inx 4771 15 users user NNS cord-010092-uftc8inx 4771 16 considered consider VBN cord-010092-uftc8inx 4771 17 tasks task NNS cord-010092-uftc8inx 4771 18 considered consider VBN cord-010092-uftc8inx 4771 19 " " `` cord-010092-uftc8inx 4771 20 very very RB cord-010092-uftc8inx 4771 21 easy easy JJ cord-010092-uftc8inx 4771 22 " " '' cord-010092-uftc8inx 4771 23 or or CC cord-010092-uftc8inx 4771 24 " " `` cord-010092-uftc8inx 4771 25 easy easy JJ cord-010092-uftc8inx 4771 26 " " '' cord-010092-uftc8inx 4771 27 ; ; : cord-010092-uftc8inx 4771 28 90 90 CD cord-010092-uftc8inx 4771 29 % % NN cord-010092-uftc8inx 4771 30 of of IN cord-010092-uftc8inx 4771 31 users user NNS cord-010092-uftc8inx 4771 32 never never RB cord-010092-uftc8inx 4771 33 found find VBD cord-010092-uftc8inx 4771 34 any any DT cord-010092-uftc8inx 4771 35 situation situation NN cord-010092-uftc8inx 4771 36 of of IN cord-010092-uftc8inx 4771 37 not not RB cord-010092-uftc8inx 4771 38 knowing know VBG cord-010092-uftc8inx 4771 39 how how WRB cord-010092-uftc8inx 4771 40 to to TO cord-010092-uftc8inx 4771 41 proceed proceed VB cord-010092-uftc8inx 4771 42 ; ; : cord-010092-uftc8inx 4771 43 and and CC cord-010092-uftc8inx 4771 44 100 100 CD cord-010092-uftc8inx 4771 45 % % NN cord-010092-uftc8inx 4771 46 of of IN cord-010092-uftc8inx 4771 47 users user NNS cord-010092-uftc8inx 4771 48 considered consider VBN cord-010092-uftc8inx 4771 49 the the DT cord-010092-uftc8inx 4771 50 maintenance maintenance NN cord-010092-uftc8inx 4771 51 Plan Plan NNP cord-010092-uftc8inx 4771 52 similar similar JJ cord-010092-uftc8inx 4771 53 or or CC cord-010092-uftc8inx 4771 54 better well JJR cord-010092-uftc8inx 4771 55 than than IN cord-010092-uftc8inx 4771 56 other other JJ cord-010092-uftc8inx 4771 57 instruments instrument NNS cord-010092-uftc8inx 4771 58 . . . cord-010092-uftc8inx 4772 1 Reliability reliability NN cord-010092-uftc8inx 4772 2 analysis analysis NN cord-010092-uftc8inx 4773 1 ( ( -LRB- cord-010092-uftc8inx 4773 2 Background background NN cord-010092-uftc8inx 4773 3 : : : cord-010092-uftc8inx 4773 4 Quality quality NN cord-010092-uftc8inx 4773 5 control control NN cord-010092-uftc8inx 4773 6 procedures procedure NNS cord-010092-uftc8inx 4773 7 in in IN cord-010092-uftc8inx 4773 8 blood blood NN cord-010092-uftc8inx 4773 9 group group NN cord-010092-uftc8inx 4773 10 serology serology NN cord-010092-uftc8inx 4773 11 for for IN cord-010092-uftc8inx 4773 12 reagents reagent NNS cord-010092-uftc8inx 4773 13 , , , cord-010092-uftc8inx 4773 14 techniques technique NNS cord-010092-uftc8inx 4773 15 , , , cord-010092-uftc8inx 4773 16 personnel personnel NNS cord-010092-uftc8inx 4773 17 working work VBG cord-010092-uftc8inx 4773 18 and and CC cord-010092-uftc8inx 4773 19 automated automated JJ cord-010092-uftc8inx 4773 20 equipment equipment NN cord-010092-uftc8inx 4773 21 are be VBP cord-010092-uftc8inx 4773 22 essential essential JJ cord-010092-uftc8inx 4773 23 for for IN cord-010092-uftc8inx 4773 24 the the DT cord-010092-uftc8inx 4773 25 accuracy accuracy NN cord-010092-uftc8inx 4773 26 of of IN cord-010092-uftc8inx 4773 27 the the DT cord-010092-uftc8inx 4773 28 laboratory laboratory NN cord-010092-uftc8inx 4773 29 results result NNS cord-010092-uftc8inx 4773 30 . . . cord-010092-uftc8inx 4774 1 The the DT cord-010092-uftc8inx 4774 2 observation observation NN cord-010092-uftc8inx 4774 3 of of IN cord-010092-uftc8inx 4774 4 high high JJ cord-010092-uftc8inx 4774 5 number number NN cord-010092-uftc8inx 4774 6 of of IN cord-010092-uftc8inx 4774 7 uninterpreted uninterpreted JJ cord-010092-uftc8inx 4774 8 results result NNS cord-010092-uftc8inx 4774 9 during during IN cord-010092-uftc8inx 4774 10 blood blood NN cord-010092-uftc8inx 4774 11 donor donor NN cord-010092-uftc8inx 4774 12 grouping grouping NN cord-010092-uftc8inx 4774 13 was be VBD cord-010092-uftc8inx 4774 14 a a DT cord-010092-uftc8inx 4774 15 motive motive NN cord-010092-uftc8inx 4774 16 for for IN cord-010092-uftc8inx 4774 17 investigation investigation NN cord-010092-uftc8inx 4774 18 and and CC cord-010092-uftc8inx 4774 19 possible possible JJ cord-010092-uftc8inx 4774 20 targeting target VBG cord-010092-uftc8inx 4774 21 the the DT cord-010092-uftc8inx 4774 22 problem problem NN cord-010092-uftc8inx 4774 23 . . . cord-010092-uftc8inx 4775 1 Aims aim VBZ cord-010092-uftc8inx 4775 2 : : : cord-010092-uftc8inx 4775 3 To to TO cord-010092-uftc8inx 4775 4 identify identify VB cord-010092-uftc8inx 4775 5 blood blood NN cord-010092-uftc8inx 4775 6 group group NN cord-010092-uftc8inx 4775 7 interpretation interpretation NN cord-010092-uftc8inx 4775 8 problems problem NNS cord-010092-uftc8inx 4775 9 by by IN cord-010092-uftc8inx 4775 10 analyzing analyze VBG cord-010092-uftc8inx 4775 11 the the DT cord-010092-uftc8inx 4775 12 testing testing NN cord-010092-uftc8inx 4775 13 results result NNS cord-010092-uftc8inx 4775 14 obtained obtain VBN cord-010092-uftc8inx 4775 15 with with IN cord-010092-uftc8inx 4775 16 the the DT cord-010092-uftc8inx 4775 17 commercial commercial JJ cord-010092-uftc8inx 4775 18 quality quality NN cord-010092-uftc8inx 4775 19 control control NN cord-010092-uftc8inx 4775 20 samples sample NNS cord-010092-uftc8inx 4775 21 routinely routinely RB cord-010092-uftc8inx 4775 22 used use VBN cord-010092-uftc8inx 4775 23 during during IN cord-010092-uftc8inx 4775 24 blood blood NN cord-010092-uftc8inx 4775 25 grouping grouping NN cord-010092-uftc8inx 4775 26 . . . cord-010092-uftc8inx 4776 1 Methods method NNS cord-010092-uftc8inx 4776 2 : : : cord-010092-uftc8inx 4777 1 A a DT cord-010092-uftc8inx 4777 2 microplate microplate NN cord-010092-uftc8inx 4777 3 ( ( -LRB- cord-010092-uftc8inx 4777 4 MP MP NNP cord-010092-uftc8inx 4777 5 ) ) -RRB- cord-010092-uftc8inx 4777 6 system system NN cord-010092-uftc8inx 4777 7 for for IN cord-010092-uftc8inx 4777 8 performing perform VBG cord-010092-uftc8inx 4777 9 ABO ABO NNP cord-010092-uftc8inx 4777 10 and and CC cord-010092-uftc8inx 4777 11 RhD RhD NNP cord-010092-uftc8inx 4777 12 , , , cord-010092-uftc8inx 4777 13 as as RB cord-010092-uftc8inx 4777 14 well well RB cord-010092-uftc8inx 4777 15 as as IN cord-010092-uftc8inx 4778 1 Rh Rh NNP cord-010092-uftc8inx 4778 2 phenotype phenotype NN cord-010092-uftc8inx 4778 3 and and CC cord-010092-uftc8inx 4778 4 Kell Kell NNP cord-010092-uftc8inx 4778 5 blood blood NN cord-010092-uftc8inx 4778 6 group group NN cord-010092-uftc8inx 4778 7 determination determination NN cord-010092-uftc8inx 4778 8 with with IN cord-010092-uftc8inx 4778 9 two two CD cord-010092-uftc8inx 4778 10 automated automate VBN cord-010092-uftc8inx 4778 11 analyzers analyzer NNS cord-010092-uftc8inx 4778 12 Techno Techno NNP cord-010092-uftc8inx 4778 13 ( ( -LRB- cord-010092-uftc8inx 4778 14 1 1 CD cord-010092-uftc8inx 4778 15 and and CC cord-010092-uftc8inx 4778 16 2 2 CD cord-010092-uftc8inx 4778 17 ) ) -RRB- cord-010092-uftc8inx 4778 18 and and CC cord-010092-uftc8inx 4778 19 correspondent correspondent NN cord-010092-uftc8inx 4778 20 two two CD cord-010092-uftc8inx 4778 21 MP MP NNP cord-010092-uftc8inx 4778 22 - - HYPH cord-010092-uftc8inx 4778 23 readers reader NNS cord-010092-uftc8inx 4778 24 Lyra Lyra NNP cord-010092-uftc8inx 4778 25 ( ( -LRB- cord-010092-uftc8inx 4778 26 1 1 CD cord-010092-uftc8inx 4778 27 and and CC cord-010092-uftc8inx 4778 28 2 2 LS cord-010092-uftc8inx 4778 29 ) ) -RRB- cord-010092-uftc8inx 4778 30 using use VBG cord-010092-uftc8inx 4778 31 Maestro Maestro NNP cord-010092-uftc8inx 4778 32 software software NN cord-010092-uftc8inx 4778 33 from from IN cord-010092-uftc8inx 4778 34 DiaMed DiaMed NNP cord-010092-uftc8inx 4778 35 is be VBZ cord-010092-uftc8inx 4778 36 currently currently RB cord-010092-uftc8inx 4778 37 in in IN cord-010092-uftc8inx 4778 38 use use NN cord-010092-uftc8inx 4778 39 for for IN cord-010092-uftc8inx 4778 40 blood blood NN cord-010092-uftc8inx 4778 41 donor donor NN cord-010092-uftc8inx 4778 42 typing typing NN cord-010092-uftc8inx 4778 43 . . . cord-010092-uftc8inx 4779 1 Three three CD cord-010092-uftc8inx 4779 2 types type NNS cord-010092-uftc8inx 4779 3 of of IN cord-010092-uftc8inx 4779 4 MP MP NNP cord-010092-uftc8inx 4779 5 are be VBP cord-010092-uftc8inx 4779 6 being be VBG cord-010092-uftc8inx 4779 7 used use VBN cord-010092-uftc8inx 4779 8 such such JJ cord-010092-uftc8inx 4779 9 as as IN cord-010092-uftc8inx 4779 10 : : : cord-010092-uftc8inx 4779 11 A a NN cord-010092-uftc8inx 4779 12 , , , cord-010092-uftc8inx 4779 13 B b NN cord-010092-uftc8inx 4779 14 , , , cord-010092-uftc8inx 4779 15 AB AB NNP cord-010092-uftc8inx 4779 16 , , , cord-010092-uftc8inx 4779 17 DVI- DVI- NNP cord-010092-uftc8inx 4779 18 , , , cord-010092-uftc8inx 4779 19 DVI+ DVI+ NNP cord-010092-uftc8inx 4779 20 , , , cord-010092-uftc8inx 4779 21 ctl ctl NNP cord-010092-uftc8inx 4779 22 / / SYM cord-010092-uftc8inx 4779 23 A1 A1 NNP cord-010092-uftc8inx 4779 24 , , , cord-010092-uftc8inx 4779 25 B B NNP cord-010092-uftc8inx 4779 26 profile profile NN cord-010092-uftc8inx 4779 27 for for IN cord-010092-uftc8inx 4779 28 first first JJ cord-010092-uftc8inx 4779 29 time time NN cord-010092-uftc8inx 4779 30 donors donor NNS cord-010092-uftc8inx 4779 31 , , , cord-010092-uftc8inx 4779 32 then then RB cord-010092-uftc8inx 4779 33 A a NN cord-010092-uftc8inx 4779 34 , , , cord-010092-uftc8inx 4779 35 B B NNP cord-010092-uftc8inx 4779 36 , , , cord-010092-uftc8inx 4779 37 D D NNP cord-010092-uftc8inx 4779 38 ctl ctl NNP cord-010092-uftc8inx 4779 39 for for IN cord-010092-uftc8inx 4779 40 repeat repeat NN cord-010092-uftc8inx 4779 41 donors donor NNS cord-010092-uftc8inx 4779 42 and and CC cord-010092-uftc8inx 4779 43 finally finally RB cord-010092-uftc8inx 4779 44 , , , cord-010092-uftc8inx 4779 45 the the DT cord-010092-uftc8inx 4779 46 C C NNP cord-010092-uftc8inx 4779 47 , , , cord-010092-uftc8inx 4779 48 c c NNP cord-010092-uftc8inx 4779 49 , , , cord-010092-uftc8inx 4779 50 E E NNP cord-010092-uftc8inx 4779 51 , , , cord-010092-uftc8inx 4779 52 e e NNP cord-010092-uftc8inx 4779 53 , , , cord-010092-uftc8inx 4779 54 K K NNP cord-010092-uftc8inx 4779 55 , , , cord-010092-uftc8inx 4779 56 ctl ctl NNP cord-010092-uftc8inx 4779 57 profile profile NN cord-010092-uftc8inx 4779 58 . . . cord-010092-uftc8inx 4780 1 The the DT cord-010092-uftc8inx 4780 2 accuracy accuracy NN cord-010092-uftc8inx 4780 3 and and CC cord-010092-uftc8inx 4780 4 safety safety NN cord-010092-uftc8inx 4780 5 of of IN cord-010092-uftc8inx 4780 6 the the DT cord-010092-uftc8inx 4780 7 blood blood NN cord-010092-uftc8inx 4780 8 grouping grouping NN cord-010092-uftc8inx 4780 9 results result NNS cord-010092-uftc8inx 4780 10 is be VBZ cord-010092-uftc8inx 4780 11 ensured ensure VBN cord-010092-uftc8inx 4780 12 by by IN cord-010092-uftc8inx 4780 13 using use VBG cord-010092-uftc8inx 4780 14 the the DT cord-010092-uftc8inx 4780 15 DiaMed DiaMed NNP cord-010092-uftc8inx 4780 16 Q.C. Q.C. NNP cord-010092-uftc8inx 4780 17 System System NNP cord-010092-uftc8inx 4780 18 which which WDT cord-010092-uftc8inx 4780 19 consists consist VBZ cord-010092-uftc8inx 4780 20 of of IN cord-010092-uftc8inx 4780 21 4 4 CD cord-010092-uftc8inx 4780 22 + + SYM cord-010092-uftc8inx 4780 23 2 2 CD cord-010092-uftc8inx 4780 24 tubes tube NNS cord-010092-uftc8inx 4780 25 of of IN cord-010092-uftc8inx 4780 26 whole whole JJ cord-010092-uftc8inx 4780 27 blood blood NN cord-010092-uftc8inx 4780 28 and and CC cord-010092-uftc8inx 4780 29 2 2 CD cord-010092-uftc8inx 4780 30 tubes tube NNS cord-010092-uftc8inx 4780 31 containing contain VBG cord-010092-uftc8inx 4780 32 serum serum NN cord-010092-uftc8inx 4780 33 with with IN cord-010092-uftc8inx 4780 34 known know VBN cord-010092-uftc8inx 4780 35 specific specific JJ cord-010092-uftc8inx 4780 36 antibodies antibody NNS cord-010092-uftc8inx 4780 37 . . . cord-010092-uftc8inx 4781 1 We -PRON- PRP cord-010092-uftc8inx 4781 2 analyzed analyze VBD cord-010092-uftc8inx 4781 3 and and CC cord-010092-uftc8inx 4781 4 compared compare VBD cord-010092-uftc8inx 4781 5 the the DT cord-010092-uftc8inx 4781 6 interpretation interpretation NN cord-010092-uftc8inx 4781 7 of of IN cord-010092-uftc8inx 4781 8 the the DT cord-010092-uftc8inx 4781 9 Q.C. Q.C. NNP cord-010092-uftc8inx 4781 10 whole whole JJ cord-010092-uftc8inx 4781 11 blood blood NN cord-010092-uftc8inx 4781 12 samples sample NNS cord-010092-uftc8inx 4781 13 ' ' POS cord-010092-uftc8inx 4781 14 results result NNS cord-010092-uftc8inx 4781 15 from from IN cord-010092-uftc8inx 4781 16 both both DT cord-010092-uftc8inx 4781 17 of of IN cord-010092-uftc8inx 4781 18 the the DT cord-010092-uftc8inx 4781 19 analyzers analyzer NNS cord-010092-uftc8inx 4781 20 after after IN cord-010092-uftc8inx 4781 21 a a DT cord-010092-uftc8inx 4781 22 new new JJ cord-010092-uftc8inx 4781 23 optic optic JJ cord-010092-uftc8inx 4781 24 camera camera NN cord-010092-uftc8inx 4781 25 was be VBD cord-010092-uftc8inx 4781 26 installed instal VBN cord-010092-uftc8inx 4781 27 on on IN cord-010092-uftc8inx 4781 28 the the DT cord-010092-uftc8inx 4781 29 Techno Techno NNP cord-010092-uftc8inx 4781 30 1 1 CD cord-010092-uftc8inx 4781 31 / / SYM cord-010092-uftc8inx 4781 32 Lyra Lyra NNP cord-010092-uftc8inx 4781 33 1 1 CD cord-010092-uftc8inx 4781 34 system system NN cord-010092-uftc8inx 4781 35 . . . cord-010092-uftc8inx 4782 1 Ward Ward NNP cord-010092-uftc8inx 4782 2 to to IN cord-010092-uftc8inx 4782 3 Ward Ward NNP cord-010092-uftc8inx 4782 4 . . . cord-010092-uftc8inx 4783 1 Methods method NNS cord-010092-uftc8inx 4783 2 : : : cord-010092-uftc8inx 4783 3 A a DT cord-010092-uftc8inx 4783 4 prospective prospective JJ cord-010092-uftc8inx 4783 5 observational observational JJ cord-010092-uftc8inx 4783 6 pilot pilot NN cord-010092-uftc8inx 4783 7 study study NN cord-010092-uftc8inx 4783 8 was be VBD cord-010092-uftc8inx 4783 9 done do VBN cord-010092-uftc8inx 4783 10 for for IN cord-010092-uftc8inx 4783 11 around around IN cord-010092-uftc8inx 4783 12 140 140 CD cord-010092-uftc8inx 4783 13 PRBC PRBC NNP cord-010092-uftc8inx 4783 14 unit unit NN cord-010092-uftc8inx 4783 15 issues issue NNS cord-010092-uftc8inx 4783 16 which which WDT cord-010092-uftc8inx 4783 17 were be VBD cord-010092-uftc8inx 4783 18 followed follow VBN cord-010092-uftc8inx 4783 19 in in IN cord-010092-uftc8inx 4783 20 real real JJ cord-010092-uftc8inx 4783 21 time time NN cord-010092-uftc8inx 4783 22 for for IN cord-010092-uftc8inx 4783 23 understanding understand VBG cord-010092-uftc8inx 4783 24 the the DT cord-010092-uftc8inx 4783 25 TAT tat NN cord-010092-uftc8inx 4783 26 within within IN cord-010092-uftc8inx 4783 27 blood blood NN cord-010092-uftc8inx 4783 28 bank bank NNP cord-010092-uftc8inx 4783 29 & & CC cord-010092-uftc8inx 4783 30 from from IN cord-010092-uftc8inx 4783 31 ward ward NNP cord-010092-uftc8inx 4783 32 to to IN cord-010092-uftc8inx 4783 33 ward ward NNP cord-010092-uftc8inx 4783 34 . . . cord-010092-uftc8inx 4784 1 As as IN cord-010092-uftc8inx 4784 2 per per IN cord-010092-uftc8inx 4784 3 the the DT cord-010092-uftc8inx 4784 4 definitions definition NNS cord-010092-uftc8inx 4784 5 , , , cord-010092-uftc8inx 4784 6 the the DT cord-010092-uftc8inx 4784 7 areas area NNS cord-010092-uftc8inx 4784 8 where where WRB cord-010092-uftc8inx 4784 9 the the DT cord-010092-uftc8inx 4784 10 times time NNS cord-010092-uftc8inx 4784 11 are be VBP cord-010092-uftc8inx 4784 12 documented document VBN cord-010092-uftc8inx 4784 13 perfectly perfectly RB cord-010092-uftc8inx 4784 14 are be VBP cord-010092-uftc8inx 4784 15 understood understand VBN cord-010092-uftc8inx 4784 16 and and CC cord-010092-uftc8inx 4784 17 considered consider VBN cord-010092-uftc8inx 4784 18 for for IN cord-010092-uftc8inx 4784 19 calculations calculation NNS cord-010092-uftc8inx 4784 20 . . . cord-010092-uftc8inx 4785 1 Based base VBN cord-010092-uftc8inx 4785 2 on on IN cord-010092-uftc8inx 4785 3 the the DT cord-010092-uftc8inx 4785 4 conclusions conclusion NNS cord-010092-uftc8inx 4785 5 of of IN cord-010092-uftc8inx 4785 6 pilot pilot NN cord-010092-uftc8inx 4785 7 study study NN cord-010092-uftc8inx 4785 8 a a DT cord-010092-uftc8inx 4785 9 monitoring monitoring NN cord-010092-uftc8inx 4785 10 form form NN cord-010092-uftc8inx 4785 11 has have VBZ cord-010092-uftc8inx 4785 12 been be VBN cord-010092-uftc8inx 4785 13 designed design VBN cord-010092-uftc8inx 4785 14 and and CC cord-010092-uftc8inx 4785 15 utilised utilise VBN cord-010092-uftc8inx 4785 16 to to TO cord-010092-uftc8inx 4785 17 monitor monitor VB cord-010092-uftc8inx 4785 18 the the DT cord-010092-uftc8inx 4785 19 TAT tat NN cord-010092-uftc8inx 4785 20 within within IN cord-010092-uftc8inx 4785 21 BB BB NNP cord-010092-uftc8inx 4785 22 & & CC cord-010092-uftc8inx 4785 23 WTW WTW NNP cord-010092-uftc8inx 4785 24 . . . cord-010092-uftc8inx 4786 1 The the DT cord-010092-uftc8inx 4786 2 data datum NNS cord-010092-uftc8inx 4786 3 is be VBZ cord-010092-uftc8inx 4786 4 analysed analyse VBN cord-010092-uftc8inx 4786 5 monthly monthly JJ cord-010092-uftc8inx 4786 6 and and CC cord-010092-uftc8inx 4786 7 an an DT cord-010092-uftc8inx 4786 8 avg avg NN cord-010092-uftc8inx 4786 9 TAT TAT NNP cord-010092-uftc8inx 4786 10 for for IN cord-010092-uftc8inx 4786 11 BB BB NNP cord-010092-uftc8inx 4786 12 & & CC cord-010092-uftc8inx 4786 13 WTW WTW NNP cord-010092-uftc8inx 4786 14 is be VBZ cord-010092-uftc8inx 4786 15 calculated calculate VBN cord-010092-uftc8inx 4786 16 . . . cord-010092-uftc8inx 4787 1 The the DT cord-010092-uftc8inx 4787 2 common common JJ cord-010092-uftc8inx 4787 3 causes cause NNS cord-010092-uftc8inx 4787 4 of of IN cord-010092-uftc8inx 4787 5 delay delay NN cord-010092-uftc8inx 4787 6 in in IN cord-010092-uftc8inx 4787 7 providing provide VBG cord-010092-uftc8inx 4787 8 the the DT cord-010092-uftc8inx 4787 9 blood blood NN cord-010092-uftc8inx 4787 10 components component NNS cord-010092-uftc8inx 4787 11 were be VBD cord-010092-uftc8inx 4787 12 analysed analyse VBN cord-010092-uftc8inx 4787 13 and and CC cord-010092-uftc8inx 4787 14 strengthened strengthen VBN cord-010092-uftc8inx 4787 15 to to IN cord-010092-uftc8inx 4787 16 both both DT cord-010092-uftc8inx 4787 17 reduce reduce VB cord-010092-uftc8inx 4787 18 & & CC cord-010092-uftc8inx 4787 19 control control VBP cord-010092-uftc8inx 4787 20 the the DT cord-010092-uftc8inx 4787 21 TAT tat NN cord-010092-uftc8inx 4787 22 . . . cord-010092-uftc8inx 4788 1 Results result NNS cord-010092-uftc8inx 4788 2 : : : cord-010092-uftc8inx 4789 1 In in IN cord-010092-uftc8inx 4789 2 pilot pilot NN cord-010092-uftc8inx 4789 3 study study NN cord-010092-uftc8inx 4789 4 , , , cord-010092-uftc8inx 4789 5 total total JJ cord-010092-uftc8inx 4789 6 WTW WTW NNP cord-010092-uftc8inx 4789 7 TAT TAT NNP cord-010092-uftc8inx 4789 8 averaged average VBD cord-010092-uftc8inx 4789 9 to to IN cord-010092-uftc8inx 4789 10 90 90 CD cord-010092-uftc8inx 4789 11 min min NN cord-010092-uftc8inx 4789 12 , , , cord-010092-uftc8inx 4789 13 with with IN cord-010092-uftc8inx 4789 14 highest high JJS cord-010092-uftc8inx 4789 15 time time NN cord-010092-uftc8inx 4789 16 taken take VBN cord-010092-uftc8inx 4789 17 795 795 CD cord-010092-uftc8inx 4789 18 min min NN cord-010092-uftc8inx 4789 19 , , , cord-010092-uftc8inx 4789 20 where where WRB cord-010092-uftc8inx 4789 21 there there EX cord-010092-uftc8inx 4789 22 were be VBD cord-010092-uftc8inx 4789 23 additional additional JJ cord-010092-uftc8inx 4789 24 processings processing NNS cord-010092-uftc8inx 4789 25 like like IN cord-010092-uftc8inx 4789 26 leukodepletion leukodepletion NN cord-010092-uftc8inx 4789 27 , , , cord-010092-uftc8inx 4789 28 irradiation irradiation NN cord-010092-uftc8inx 4789 29 , , , cord-010092-uftc8inx 4789 30 Saline Saline NNP cord-010092-uftc8inx 4789 31 washing washing NN cord-010092-uftc8inx 4789 32 of of IN cord-010092-uftc8inx 4789 33 red red JJ cord-010092-uftc8inx 4789 34 cells cell NNS cord-010092-uftc8inx 4789 35 and and CC cord-010092-uftc8inx 4789 36 holding hold VBG cord-010092-uftc8inx 4789 37 the the DT cord-010092-uftc8inx 4789 38 transfusion transfusion NN cord-010092-uftc8inx 4789 39 . . . cord-010092-uftc8inx 4790 1 Lowest low JJS cord-010092-uftc8inx 4790 2 WTW WTW NNP cord-010092-uftc8inx 4790 3 TAT TAT NNP cord-010092-uftc8inx 4790 4 was be VBD cord-010092-uftc8inx 4790 5 found find VBN cord-010092-uftc8inx 4790 6 to to TO cord-010092-uftc8inx 4790 7 be be VB cord-010092-uftc8inx 4790 8 10 10 CD cord-010092-uftc8inx 4790 9 min min NN cord-010092-uftc8inx 4790 10 where where WRB cord-010092-uftc8inx 4790 11 there there EX cord-010092-uftc8inx 4790 12 was be VBD cord-010092-uftc8inx 4790 13 a a DT cord-010092-uftc8inx 4790 14 prior prior JJ cord-010092-uftc8inx 4790 15 information information NN cord-010092-uftc8inx 4790 16 for for IN cord-010092-uftc8inx 4790 17 crossmatch crossmatch NN cord-010092-uftc8inx 4790 18 . . . cord-010092-uftc8inx 4791 1 After after IN cord-010092-uftc8inx 4791 2 the the DT cord-010092-uftc8inx 4791 3 surveillance surveillance NN cord-010092-uftc8inx 4791 4 form form NN cord-010092-uftc8inx 4791 5 has have VBZ cord-010092-uftc8inx 4791 6 been be VBN cord-010092-uftc8inx 4791 7 started start VBN cord-010092-uftc8inx 4791 8 , , , cord-010092-uftc8inx 4791 9 the the DT cord-010092-uftc8inx 4791 10 average average JJ cord-010092-uftc8inx 4791 11 time time NN cord-010092-uftc8inx 4791 12 taken take VBN cord-010092-uftc8inx 4791 13 for for IN cord-010092-uftc8inx 4791 14 WTW WTW NNP cord-010092-uftc8inx 4791 15 TAT TAT NNP cord-010092-uftc8inx 4791 16 came come VBD cord-010092-uftc8inx 4791 17 down down RP cord-010092-uftc8inx 4791 18 to to IN cord-010092-uftc8inx 4791 19 70 70 CD cord-010092-uftc8inx 4791 20 min min NN cord-010092-uftc8inx 4791 21 , , , cord-010092-uftc8inx 4791 22 maximum maximum JJ cord-010092-uftc8inx 4791 23 being being NN cord-010092-uftc8inx 4791 24 310 310 CD cord-010092-uftc8inx 4791 25 min min NN cord-010092-uftc8inx 4791 26 ( ( -LRB- cord-010092-uftc8inx 4791 27 Jan Jan NNP cord-010092-uftc8inx 4791 28 2019 2019 CD cord-010092-uftc8inx 4791 29 ) ) -RRB- cord-010092-uftc8inx 4791 30 , , , cord-010092-uftc8inx 4791 31 The the DT cord-010092-uftc8inx 4791 32 areas area NNS cord-010092-uftc8inx 4791 33 where where WRB cord-010092-uftc8inx 4791 34 delay delay NN cord-010092-uftc8inx 4791 35 happened happen VBD cord-010092-uftc8inx 4791 36 were be VBD cord-010092-uftc8inx 4791 37 identified identify VBN cord-010092-uftc8inx 4791 38 as as IN cord-010092-uftc8inx 4791 39 internal internal JJ cord-010092-uftc8inx 4791 40 courier courier NN cord-010092-uftc8inx 4791 41 delays delay NNS cord-010092-uftc8inx 4791 42 , , , cord-010092-uftc8inx 4791 43 Technician technician NN cord-010092-uftc8inx 4791 44 delays delay NNS cord-010092-uftc8inx 4791 45 , , , cord-010092-uftc8inx 4791 46 billing bill VBG cord-010092-uftc8inx 4791 47 & & CC cord-010092-uftc8inx 4791 48 other other JJ cord-010092-uftc8inx 4791 49 logistics logistic NNS cord-010092-uftc8inx 4791 50 delay delay NN cord-010092-uftc8inx 4791 51 . . . cord-010092-uftc8inx 4792 1 The the DT cord-010092-uftc8inx 4792 2 concerned concerned JJ cord-010092-uftc8inx 4792 3 staff staff NN cord-010092-uftc8inx 4792 4 are be VBP cord-010092-uftc8inx 4792 5 put put VBN cord-010092-uftc8inx 4792 6 on on IN cord-010092-uftc8inx 4792 7 regular regular JJ cord-010092-uftc8inx 4792 8 training training NN cord-010092-uftc8inx 4792 9 to to TO cord-010092-uftc8inx 4792 10 maintain maintain VB cord-010092-uftc8inx 4792 11 the the DT cord-010092-uftc8inx 4792 12 TAT tat NN cord-010092-uftc8inx 4792 13 . . . cord-010092-uftc8inx 4793 1 Summary Summary NNP cord-010092-uftc8inx 4793 2 / / SYM cord-010092-uftc8inx 4793 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 4793 4 : : : cord-010092-uftc8inx 4794 1 Although although IN cord-010092-uftc8inx 4794 2 ethically ethically RB cord-010092-uftc8inx 4794 3 all all PDT cord-010092-uftc8inx 4794 4 the the DT cord-010092-uftc8inx 4794 5 staff staff NN cord-010092-uftc8inx 4794 6 work work NN cord-010092-uftc8inx 4794 7 for for IN cord-010092-uftc8inx 4794 8 providing provide VBG cord-010092-uftc8inx 4794 9 better well JJR cord-010092-uftc8inx 4794 10 care care NN cord-010092-uftc8inx 4794 11 for for IN cord-010092-uftc8inx 4794 12 patients patient NNS cord-010092-uftc8inx 4794 13 , , , cord-010092-uftc8inx 4794 14 there there EX cord-010092-uftc8inx 4794 15 will will MD cord-010092-uftc8inx 4794 16 be be VB cord-010092-uftc8inx 4794 17 few few JJ cord-010092-uftc8inx 4794 18 areas area NNS cord-010092-uftc8inx 4794 19 that that WDT cord-010092-uftc8inx 4794 20 delay delay VBP cord-010092-uftc8inx 4794 21 the the DT cord-010092-uftc8inx 4794 22 life life NN cord-010092-uftc8inx 4794 23 supporting support VBG cord-010092-uftc8inx 4794 24 blood blood NN cord-010092-uftc8inx 4794 25 transfusion transfusion NN cord-010092-uftc8inx 4794 26 . . . cord-010092-uftc8inx 4795 1 Monitoring monitor VBG cord-010092-uftc8inx 4795 2 using use VBG cord-010092-uftc8inx 4795 3 TAT tat NN cord-010092-uftc8inx 4795 4 surveillance surveillance NN cord-010092-uftc8inx 4795 5 forms form NNS cord-010092-uftc8inx 4795 6 help help NN cord-010092-uftc8inx 4795 7 in in IN cord-010092-uftc8inx 4795 8 avoiding avoid VBG cord-010092-uftc8inx 4795 9 the the DT cord-010092-uftc8inx 4795 10 delays delay NNS cord-010092-uftc8inx 4795 11 and and CC cord-010092-uftc8inx 4795 12 hence hence RB cord-010092-uftc8inx 4795 13 provide provide VB cord-010092-uftc8inx 4795 14 better well JJR cord-010092-uftc8inx 4795 15 & & CC cord-010092-uftc8inx 4795 16 timely timely JJ cord-010092-uftc8inx 4795 17 transfusion transfusion NN cord-010092-uftc8inx 4795 18 support support NN cord-010092-uftc8inx 4795 19 . . . cord-010092-uftc8inx 4796 1 Blood blood NN cord-010092-uftc8inx 4796 2 donation donation NN cord-010092-uftc8inx 4797 1 -Blood -Blood : cord-010092-uftc8inx 4797 2 donor donor NN cord-010092-uftc8inx 4797 3 recruitment recruitment NN cord-010092-uftc8inx 4797 4 P-059 p-059 IN cord-010092-uftc8inx 4797 5 HEMATOLOGICAL HEMATOLOGICAL NNP cord-010092-uftc8inx 4797 6 AND and CC cord-010092-uftc8inx 4797 7 PHYSIOLOGICAL physiological JJ cord-010092-uftc8inx 4797 8 CHARACTERISTICS characteristic NNS cord-010092-uftc8inx 4797 9 OF of IN cord-010092-uftc8inx 4797 10 REGULAR regular JJ cord-010092-uftc8inx 4797 11 BLOOD blood NN cord-010092-uftc8inx 4797 12 DONORS donor NNS cord-010092-uftc8inx 4797 13 WITH with IN cord-010092-uftc8inx 4797 14 BETA BETA NNP cord-010092-uftc8inx 4797 15 - - HYPH cord-010092-uftc8inx 4797 16 THALASSEMIA THALASSEMIA NNP cord-010092-uftc8inx 4797 17 TRAITS TRAITS NNP cord-010092-uftc8inx 4797 18 Background background NN cord-010092-uftc8inx 4797 19 : : : cord-010092-uftc8inx 4798 1 According accord VBG cord-010092-uftc8inx 4798 2 to to IN cord-010092-uftc8inx 4798 3 recent recent JJ cord-010092-uftc8inx 4798 4 evidence evidence NN cord-010092-uftc8inx 4798 5 , , , cord-010092-uftc8inx 4798 6 the the DT cord-010092-uftc8inx 4798 7 physiological physiological JJ cord-010092-uftc8inx 4798 8 variability variability NN cord-010092-uftc8inx 4798 9 observed observe VBN cord-010092-uftc8inx 4798 10 in in IN cord-010092-uftc8inx 4798 11 the the DT cord-010092-uftc8inx 4798 12 hematological hematological JJ cord-010092-uftc8inx 4798 13 characteristics characteristic NNS cord-010092-uftc8inx 4798 14 of of IN cord-010092-uftc8inx 4798 15 regular regular JJ cord-010092-uftc8inx 4798 16 blood blood NN cord-010092-uftc8inx 4798 17 donors donor NNS cord-010092-uftc8inx 4798 18 ( ( -LRB- cord-010092-uftc8inx 4798 19 linked link VBN cord-010092-uftc8inx 4798 20 -in -in : cord-010092-uftc8inx 4798 21 certain certain JJ cord-010092-uftc8inx 4798 22 caseswith caseswith JJ cord-010092-uftc8inx 4798 23 genetic genetic JJ cord-010092-uftc8inx 4798 24 factors factor NNS cord-010092-uftc8inx 4798 25 or or CC cord-010092-uftc8inx 4798 26 the the DT cord-010092-uftc8inx 4798 27 donor donor NN cord-010092-uftc8inx 4798 28 's 's POS cord-010092-uftc8inx 4798 29 lifestyle lifestyle NN cord-010092-uftc8inx 4798 30 ) ) -RRB- cord-010092-uftc8inx 4798 31 may may MD cord-010092-uftc8inx 4798 32 affect affect VB cord-010092-uftc8inx 4798 33 red red JJ cord-010092-uftc8inx 4798 34 blood blood NN cord-010092-uftc8inx 4798 35 cell cell NN cord-010092-uftc8inx 4798 36 ( ( -LRB- cord-010092-uftc8inx 4798 37 RBC RBC NNP cord-010092-uftc8inx 4798 38 ) ) -RRB- cord-010092-uftc8inx 4798 39 storage storage NN cord-010092-uftc8inx 4798 40 lesion lesion NN cord-010092-uftc8inx 4798 41 . . . cord-010092-uftc8inx 4799 1 Beta beta JJ cord-010092-uftc8inx 4799 2 - - HYPH cord-010092-uftc8inx 4799 3 thalassemia thalassemia NN cord-010092-uftc8inx 4799 4 heterozygous heterozygous NN cord-010092-uftc8inx 4799 5 ( ( -LRB- cord-010092-uftc8inx 4799 6 b b NNP cord-010092-uftc8inx 4799 7 - - HYPH cord-010092-uftc8inx 4799 8 thal thal NNP cord-010092-uftc8inx 4799 9 - - HYPH cord-010092-uftc8inx 4799 10 het het NNP cord-010092-uftc8inx 4799 11 ) ) -RRB- cord-010092-uftc8inx 4799 12 blood blood NN cord-010092-uftc8inx 4799 13 donors donor NNS cord-010092-uftc8inx 4799 14 represent represent VBP cord-010092-uftc8inx 4799 15 a a DT cord-010092-uftc8inx 4799 16 group group NN cord-010092-uftc8inx 4799 17 of of IN cord-010092-uftc8inx 4799 18 particular particular JJ cord-010092-uftc8inx 4799 19 interest interest NN cord-010092-uftc8inx 4799 20 because because IN cord-010092-uftc8inx 4799 21 of of IN cord-010092-uftc8inx 4799 22 a a DT cord-010092-uftc8inx 4799 23 ) ) -RRB- cord-010092-uftc8inx 4800 1 the the DT cord-010092-uftc8inx 4800 2 high high JJ cord-010092-uftc8inx 4800 3 frequency frequency NN cord-010092-uftc8inx 4800 4 of of IN cord-010092-uftc8inx 4800 5 thalassemia thalassemia NN cord-010092-uftc8inx 4800 6 mutations mutation NNS cord-010092-uftc8inx 4800 7 in in IN cord-010092-uftc8inx 4800 8 specific specific JJ cord-010092-uftc8inx 4800 9 geographical geographical JJ cord-010092-uftc8inx 4800 10 areas area NNS cord-010092-uftc8inx 4800 11 b b LS cord-010092-uftc8inx 4800 12 ) ) -RRB- cord-010092-uftc8inx 4801 1 the the DT cord-010092-uftc8inx 4801 2 physiology physiology NN cord-010092-uftc8inx 4801 3 of of IN cord-010092-uftc8inx 4801 4 the the DT cord-010092-uftc8inx 4801 5 b b NNP cord-010092-uftc8inx 4801 6 - - HYPH cord-010092-uftc8inx 4801 7 thal thal NNP cord-010092-uftc8inx 4801 8 - - HYPH cord-010092-uftc8inx 4801 9 het het NNP cord-010092-uftc8inx 4801 10 RBCs rbc NNS cord-010092-uftc8inx 4801 11 , , , cord-010092-uftc8inx 4801 12 which which WDT cord-010092-uftc8inx 4801 13 predisposes predispose VBZ cord-010092-uftc8inx 4801 14 towards towards IN cord-010092-uftc8inx 4801 15 more more JJR cord-010092-uftc8inx 4801 16 effective effective JJ cord-010092-uftc8inx 4801 17 management management NN cord-010092-uftc8inx 4801 18 of of IN cord-010092-uftc8inx 4801 19 storage storage NN cord-010092-uftc8inx 4801 20 - - HYPH cord-010092-uftc8inx 4801 21 associated associate VBN cord-010092-uftc8inx 4801 22 stress stress NN cord-010092-uftc8inx 4801 23 . . . cord-010092-uftc8inx 4802 1 Aims aim VBZ cord-010092-uftc8inx 4802 2 : : : cord-010092-uftc8inx 4803 1 The the DT cord-010092-uftc8inx 4803 2 goal goal NN cord-010092-uftc8inx 4803 3 of of IN cord-010092-uftc8inx 4803 4 the the DT cord-010092-uftc8inx 4803 5 present present JJ cord-010092-uftc8inx 4803 6 study study NN cord-010092-uftc8inx 4803 7 was be VBD cord-010092-uftc8inx 4803 8 the the DT cord-010092-uftc8inx 4803 9 comparative comparative JJ cord-010092-uftc8inx 4803 10 examination examination NN cord-010092-uftc8inx 4803 11 of of IN cord-010092-uftc8inx 4803 12 the the DT cord-010092-uftc8inx 4803 13 hematological hematological JJ cord-010092-uftc8inx 4803 14 and and CC cord-010092-uftc8inx 4803 15 RBC RBC NNP cord-010092-uftc8inx 4803 16 physiological physiological JJ cord-010092-uftc8inx 4803 17 features feature NNS cord-010092-uftc8inx 4803 18 of of IN cord-010092-uftc8inx 4803 19 regular regular JJ cord-010092-uftc8inx 4803 20 blood blood NN cord-010092-uftc8inx 4803 21 donors donor NNS cord-010092-uftc8inx 4803 22 with with IN cord-010092-uftc8inx 4803 23 or or CC cord-010092-uftc8inx 4803 24 without without IN cord-010092-uftc8inx 4803 25 beta beta NN cord-010092-uftc8inx 4803 26 - - HYPH cord-010092-uftc8inx 4803 27 thalassemia thalassemia NN cord-010092-uftc8inx 4803 28 traits trait NNS cord-010092-uftc8inx 4803 29 before before IN cord-010092-uftc8inx 4803 30 blood blood NN cord-010092-uftc8inx 4803 31 processing processing NN cord-010092-uftc8inx 4803 32 for for IN cord-010092-uftc8inx 4803 33 transfusion transfusion NN cord-010092-uftc8inx 4803 34 purposes purpose NNS cord-010092-uftc8inx 4803 35 . . . cord-010092-uftc8inx 4804 1 Methods method NNS cord-010092-uftc8inx 4804 2 : : : cord-010092-uftc8inx 4804 3 204 204 CD cord-010092-uftc8inx 4804 4 healthy healthy JJ cord-010092-uftc8inx 4804 5 blood blood NN cord-010092-uftc8inx 4804 6 donors donor NNS cord-010092-uftc8inx 4804 7 of of IN cord-010092-uftc8inx 4804 8 Greek greek JJ cord-010092-uftc8inx 4804 9 origin origin NN cord-010092-uftc8inx 4804 10 ( ( -LRB- cord-010092-uftc8inx 4804 11 18 18 CD cord-010092-uftc8inx 4804 12 - - SYM cord-010092-uftc8inx 4804 13 24 24 CD cord-010092-uftc8inx 4804 14 years year NNS cord-010092-uftc8inx 4804 15 old old JJ cord-010092-uftc8inx 4804 16 ) ) -RRB- cord-010092-uftc8inx 4804 17 , , , cord-010092-uftc8inx 4804 18 who who WP cord-010092-uftc8inx 4804 19 met meet VBD cord-010092-uftc8inx 4804 20 the the DT cord-010092-uftc8inx 4804 21 blood blood NN cord-010092-uftc8inx 4804 22 donation donation NN cord-010092-uftc8inx 4804 23 criteria criterion NNS cord-010092-uftc8inx 4804 24 were be VBD cord-010092-uftc8inx 4804 25 recruited recruit VBN cord-010092-uftc8inx 4804 26 in in IN cord-010092-uftc8inx 4804 27 this this DT cord-010092-uftc8inx 4804 28 study study NN cord-010092-uftc8inx 4804 29 . . . cord-010092-uftc8inx 4805 1 Plasma plasma NN cord-010092-uftc8inx 4805 2 / / SYM cord-010092-uftc8inx 4805 3 serum serum NN cord-010092-uftc8inx 4805 4 ( ( -LRB- cord-010092-uftc8inx 4805 5 uric uric NN cord-010092-uftc8inx 4805 6 acid acid NN cord-010092-uftc8inx 4805 7 , , , cord-010092-uftc8inx 4805 8 electrolytes electrolyte NNS cord-010092-uftc8inx 4805 9 , , , cord-010092-uftc8inx 4805 10 extracellular extracellular JJ cord-010092-uftc8inx 4805 11 hemoglobin hemoglobin NN cord-010092-uftc8inx 4805 12 , , , cord-010092-uftc8inx 4805 13 antioxidant antioxidant NN cord-010092-uftc8inx 4805 14 capacity capacity NN cord-010092-uftc8inx 4805 15 ) ) -RRB- cord-010092-uftc8inx 4805 16 , , , cord-010092-uftc8inx 4805 17 cellular cellular JJ cord-010092-uftc8inx 4805 18 ( ( -LRB- cord-010092-uftc8inx 4805 19 RBC RBC NNP cord-010092-uftc8inx 4805 20 indices index NNS cord-010092-uftc8inx 4805 21 ) ) -RRB- cord-010092-uftc8inx 4805 22 and and CC cord-010092-uftc8inx 4805 23 biological biological JJ cord-010092-uftc8inx 4805 24 parameters parameter NNS cord-010092-uftc8inx 4805 25 ( ( -LRB- cord-010092-uftc8inx 4805 26 corpuscular corpuscular JJ cord-010092-uftc8inx 4805 27 fragility fragility NN cord-010092-uftc8inx 4805 28 , , , cord-010092-uftc8inx 4805 29 proteasomal proteasomal JJ cord-010092-uftc8inx 4805 30 activity activity NN cord-010092-uftc8inx 4805 31 etc etc FW cord-010092-uftc8inx 4805 32 ) ) -RRB- cord-010092-uftc8inx 4805 33 were be VBD cord-010092-uftc8inx 4805 34 measured measure VBN cord-010092-uftc8inx 4805 35 . . . cord-010092-uftc8inx 4806 1 The the DT cord-010092-uftc8inx 4806 2 results result NNS cord-010092-uftc8inx 4806 3 were be VBD cord-010092-uftc8inx 4806 4 statistically statistically RB cord-010092-uftc8inx 4806 5 analyzed analyze VBN cord-010092-uftc8inx 4806 6 and and CC cord-010092-uftc8inx 4806 7 topologically topologically RB cord-010092-uftc8inx 4806 8 represented represent VBN cord-010092-uftc8inx 4806 9 in in IN cord-010092-uftc8inx 4806 10 biological biological JJ cord-010092-uftc8inx 4806 11 networks network NNS cord-010092-uftc8inx 4806 12 for for IN cord-010092-uftc8inx 4806 13 both both DT cord-010092-uftc8inx 4806 14 donor donor NN cord-010092-uftc8inx 4806 15 groups group NNS cord-010092-uftc8inx 4806 16 ( ( -LRB- cord-010092-uftc8inx 4806 17 + + CC cord-010092-uftc8inx 4806 18 /-b /-b . cord-010092-uftc8inx 4806 19 - - HYPH cord-010092-uftc8inx 4806 20 thal thal NNP cord-010092-uftc8inx 4806 21 - - HYPH cord-010092-uftc8inx 4806 22 het het NNP cord-010092-uftc8inx 4806 23 ) ) -RRB- cord-010092-uftc8inx 4806 24 . . . cord-010092-uftc8inx 4807 1 Significance significance NN cord-010092-uftc8inx 4807 2 was be VBD cord-010092-uftc8inx 4807 3 accepted accept VBN cord-010092-uftc8inx 4807 4 at at IN cord-010092-uftc8inx 4807 5 P p NN cord-010092-uftc8inx 4807 6 < < XX cord-010092-uftc8inx 4807 7 0.05 0.05 CD cord-010092-uftc8inx 4807 8 . . . cord-010092-uftc8inx 4808 1 Results result NNS cord-010092-uftc8inx 4808 2 : : : cord-010092-uftc8inx 4809 1 b b LS cord-010092-uftc8inx 4809 2 - - : cord-010092-uftc8inx 4809 3 thal thal NNP cord-010092-uftc8inx 4809 4 - - HYPH cord-010092-uftc8inx 4809 5 het het NNP cord-010092-uftc8inx 4809 6 represented represent VBD cord-010092-uftc8inx 4809 7 9 9 CD cord-010092-uftc8inx 4809 8 % % NN cord-010092-uftc8inx 4809 9 of of IN cord-010092-uftc8inx 4809 10 the the DT cord-010092-uftc8inx 4809 11 donor donor NN cord-010092-uftc8inx 4809 12 cohort cohort NN cord-010092-uftc8inx 4809 13 . . . cord-010092-uftc8inx 4810 1 No no DT cord-010092-uftc8inx 4810 2 differences difference NNS cord-010092-uftc8inx 4810 3 in in IN cord-010092-uftc8inx 4810 4 lifestyle lifestyle NN cord-010092-uftc8inx 4810 5 ( ( -LRB- cord-010092-uftc8inx 4810 6 smoking smoking NN cord-010092-uftc8inx 4810 7 , , , cord-010092-uftc8inx 4810 8 alcohol alcohol NN cord-010092-uftc8inx 4810 9 consumption consumption NN cord-010092-uftc8inx 4810 10 , , , cord-010092-uftc8inx 4810 11 physical physical JJ cord-010092-uftc8inx 4810 12 exercise exercise NN cord-010092-uftc8inx 4810 13 ) ) -RRB- cord-010092-uftc8inx 4810 14 were be VBD cord-010092-uftc8inx 4810 15 observed observe VBN cord-010092-uftc8inx 4810 16 between between IN cord-010092-uftc8inx 4810 17 the the DT cord-010092-uftc8inx 4810 18 two two CD cord-010092-uftc8inx 4810 19 groups group NNS cord-010092-uftc8inx 4810 20 . . . cord-010092-uftc8inx 4811 1 Nevertheless nevertheless RB cord-010092-uftc8inx 4811 2 , , , cord-010092-uftc8inx 4811 3 regardless regardless RB cord-010092-uftc8inx 4811 4 of of IN cord-010092-uftc8inx 4811 5 sex sex NN cord-010092-uftc8inx 4811 6 and and CC cord-010092-uftc8inx 4811 7 sex sex NN cord-010092-uftc8inx 4811 8 - - HYPH cord-010092-uftc8inx 4811 9 dependent dependent JJ cord-010092-uftc8inx 4811 10 parameters parameter NNS cord-010092-uftc8inx 4811 11 ( ( -LRB- cord-010092-uftc8inx 4811 12 e.g. e.g. RB cord-010092-uftc8inx 4811 13 Hct Hct NNP cord-010092-uftc8inx 4811 14 , , , cord-010092-uftc8inx 4811 15 Hb Hb NNP cord-010092-uftc8inx 4811 16 concentration concentration NN cord-010092-uftc8inx 4811 17 ) ) -RRB- cord-010092-uftc8inx 4811 18 , , , cord-010092-uftc8inx 4811 19 b b NNP cord-010092-uftc8inx 4811 20 - - HYPH cord-010092-uftc8inx 4811 21 thal thal NNP cord-010092-uftc8inx 4811 22 - - HYPH cord-010092-uftc8inx 4811 23 het het NNP cord-010092-uftc8inx 4811 24 demonstrated demonstrate VBD cord-010092-uftc8inx 4811 25 : : : cord-010092-uftc8inx 4811 26 a a LS cord-010092-uftc8inx 4811 27 ) ) -RRB- cord-010092-uftc8inx 4811 28 reduced reduce VBN cord-010092-uftc8inx 4811 29 Hct Hct NNP cord-010092-uftc8inx 4811 30 , , , cord-010092-uftc8inx 4811 31 MCV MCV NNP cord-010092-uftc8inx 4811 32 and and CC cord-010092-uftc8inx 4811 33 MCH MCH NNP cord-010092-uftc8inx 4811 34 ( ( -LRB- cord-010092-uftc8inx 4811 35 11 11 CD cord-010092-uftc8inx 4811 36 % % NN cord-010092-uftc8inx 4811 37 P p NN cord-010092-uftc8inx 4811 38 = = SYM cord-010092-uftc8inx 4811 39 0.039 0.039 CD cord-010092-uftc8inx 4811 40 , , , cord-010092-uftc8inx 4811 41 26 26 CD cord-010092-uftc8inx 4811 42 % % NN cord-010092-uftc8inx 4811 43 P p NN cord-010092-uftc8inx 4811 44 = = SYM cord-010092-uftc8inx 4811 45 0.008 0.008 CD cord-010092-uftc8inx 4811 46 and and CC cord-010092-uftc8inx 4811 47 30 30 CD cord-010092-uftc8inx 4811 48 % % NN cord-010092-uftc8inx 4811 49 P p NN cord-010092-uftc8inx 4811 50 = = SYM cord-010092-uftc8inx 4811 51 0.006 0.006 CD cord-010092-uftc8inx 4811 52 , , , cord-010092-uftc8inx 4811 53 respectively respectively RB cord-010092-uftc8inx 4811 54 ) ) -RRB- cord-010092-uftc8inx 4811 55 and and CC cord-010092-uftc8inx 4811 56 b b LS cord-010092-uftc8inx 4811 57 ) ) -RRB- cord-010092-uftc8inx 4811 58 increased increase VBD cord-010092-uftc8inx 4811 59 RBC RBC NNP cord-010092-uftc8inx 4811 60 count count NN cord-010092-uftc8inx 4811 61 ( ( -LRB- cord-010092-uftc8inx 4811 62 20 20 CD cord-010092-uftc8inx 4811 63 % % NN cord-010092-uftc8inx 4811 64 , , , cord-010092-uftc8inx 4811 65 P p NN cord-010092-uftc8inx 4811 66 = = SYM cord-010092-uftc8inx 4811 67 0.042 0.042 CD cord-010092-uftc8inx 4811 68 ) ) -RRB- cord-010092-uftc8inx 4811 69 compared compare VBN cord-010092-uftc8inx 4811 70 to to IN cord-010092-uftc8inx 4811 71 the the DT cord-010092-uftc8inx 4811 72 average average JJ cord-010092-uftc8inx 4811 73 donors donor NNS cord-010092-uftc8inx 4811 74 . . . cord-010092-uftc8inx 4812 1 Moreover moreover RB cord-010092-uftc8inx 4812 2 , , , cord-010092-uftc8inx 4812 3 MPV MPV NNP cord-010092-uftc8inx 4812 4 platelet platelet NN cord-010092-uftc8inx 4812 5 index index NN cord-010092-uftc8inx 4812 6 was be VBD cord-010092-uftc8inx 4812 7 found find VBN cord-010092-uftc8inx 4812 8 slightly slightly RB cord-010092-uftc8inx 4812 9 elevated elevate VBN cord-010092-uftc8inx 4812 10 ( ( -LRB- cord-010092-uftc8inx 4812 11 P p NN cord-010092-uftc8inx 4812 12 = = SYM cord-010092-uftc8inx 4812 13 0.053 0.053 CD cord-010092-uftc8inx 4812 14 ) ) -RRB- cord-010092-uftc8inx 4812 15 and and CC cord-010092-uftc8inx 4812 16 serum serum JJ cord-010092-uftc8inx 4812 17 total total JJ cord-010092-uftc8inx 4812 18 protein protein NN cord-010092-uftc8inx 4812 19 concentration concentration NN cord-010092-uftc8inx 4812 20 slightly slightly RB cord-010092-uftc8inx 4812 21 reduced reduce VBN cord-010092-uftc8inx 4812 22 ( ( -LRB- cord-010092-uftc8inx 4812 23 P p NN cord-010092-uftc8inx 4812 24 = = SYM cord-010092-uftc8inx 4812 25 0.054 0.054 CD cord-010092-uftc8inx 4812 26 ) ) -RRB- cord-010092-uftc8inx 4812 27 in in IN cord-010092-uftc8inx 4812 28 the the DT cord-010092-uftc8inx 4812 29 same same JJ cord-010092-uftc8inx 4812 30 group group NN cord-010092-uftc8inx 4812 31 . . . cord-010092-uftc8inx 4813 1 A a DT cord-010092-uftc8inx 4813 2 trend trend NN cord-010092-uftc8inx 4813 3 for for IN cord-010092-uftc8inx 4813 4 higher high JJR cord-010092-uftc8inx 4813 5 plasma plasma NN cord-010092-uftc8inx 4813 6 antioxidant antioxidant NN cord-010092-uftc8inx 4813 7 capacity capacity NN cord-010092-uftc8inx 4813 8 ( ( -LRB- cord-010092-uftc8inx 4813 9 P p NN cord-010092-uftc8inx 4813 10 = = SYM cord-010092-uftc8inx 4813 11 0.052 0.052 CD cord-010092-uftc8inx 4813 12 ) ) -RRB- cord-010092-uftc8inx 4813 13 was be VBD cord-010092-uftc8inx 4813 14 evident evident JJ cord-010092-uftc8inx 4813 15 in in IN cord-010092-uftc8inx 4813 16 the the DT cord-010092-uftc8inx 4813 17 group group NN cord-010092-uftc8inx 4813 18 of of IN cord-010092-uftc8inx 4813 19 b b NNP cord-010092-uftc8inx 4813 20 - - HYPH cord-010092-uftc8inx 4813 21 thal thal NNP cord-010092-uftc8inx 4813 22 - - HYPH cord-010092-uftc8inx 4813 23 het het NNP cord-010092-uftc8inx 4813 24 , , , cord-010092-uftc8inx 4813 25 in in IN cord-010092-uftc8inx 4813 26 addition addition NN cord-010092-uftc8inx 4813 27 to to IN cord-010092-uftc8inx 4813 28 statistically statistically RB cord-010092-uftc8inx 4813 29 significant significant JJ cord-010092-uftc8inx 4813 30 lower low JJR cord-010092-uftc8inx 4813 31 levels level NNS cord-010092-uftc8inx 4813 32 of of IN cord-010092-uftc8inx 4813 33 osmotic osmotic JJ cord-010092-uftc8inx 4813 34 fragility fragility NN cord-010092-uftc8inx 4813 35 ( ( -LRB- cord-010092-uftc8inx 4813 36 by by IN cord-010092-uftc8inx 4813 37 13 13 CD cord-010092-uftc8inx 4813 38 % % NN cord-010092-uftc8inx 4813 39 , , , cord-010092-uftc8inx 4813 40 P p NN cord-010092-uftc8inx 4813 41 = = SYM cord-010092-uftc8inx 4813 42 0.022 0.022 CD cord-010092-uftc8inx 4813 43 ) ) -RRB- cord-010092-uftc8inx 4813 44 and and CC cord-010092-uftc8inx 4813 45 hemolysis hemolysis NN cord-010092-uftc8inx 4813 46 ( ( -LRB- cord-010092-uftc8inx 4813 47 by by IN cord-010092-uftc8inx 4813 48 41 41 CD cord-010092-uftc8inx 4813 49 % % NN cord-010092-uftc8inx 4813 50 , , , cord-010092-uftc8inx 4813 51 P p NN cord-010092-uftc8inx 4813 52 = = SYM cord-010092-uftc8inx 4813 53 0.001 0.001 CD cord-010092-uftc8inx 4813 54 ) ) -RRB- cord-010092-uftc8inx 4813 55 compared compare VBN cord-010092-uftc8inx 4813 56 to to IN cord-010092-uftc8inx 4813 57 controls control NNS cord-010092-uftc8inx 4813 58 . . . cord-010092-uftc8inx 4814 1 Finally finally RB cord-010092-uftc8inx 4814 2 , , , cord-010092-uftc8inx 4814 3 analysis analysis NN cord-010092-uftc8inx 4814 4 of of IN cord-010092-uftc8inx 4814 5 the the DT cord-010092-uftc8inx 4814 6 three three CD cord-010092-uftc8inx 4814 7 proteasome proteasome NN cord-010092-uftc8inx 4814 8 - - HYPH cord-010092-uftc8inx 4814 9 associated associate VBN cord-010092-uftc8inx 4814 10 enzymatic enzymatic JJ cord-010092-uftc8inx 4814 11 activities activity NNS cord-010092-uftc8inx 4814 12 ( ( -LRB- cord-010092-uftc8inx 4814 13 N n NN cord-010092-uftc8inx 4814 14 = = SYM cord-010092-uftc8inx 4814 15 10 10 CD cord-010092-uftc8inx 4814 16 per per IN cord-010092-uftc8inx 4814 17 group group NN cord-010092-uftc8inx 4814 18 ) ) -RRB- cord-010092-uftc8inx 4814 19 in in IN cord-010092-uftc8inx 4814 20 the the DT cord-010092-uftc8inx 4814 21 RBC RBC NNP cord-010092-uftc8inx 4814 22 cytosol cytosol NN cord-010092-uftc8inx 4814 23 and and CC cord-010092-uftc8inx 4814 24 the the DT cord-010092-uftc8inx 4814 25 membrane membrane NN cord-010092-uftc8inx 4814 26 , , , cord-010092-uftc8inx 4814 27 revealed reveal VBD cord-010092-uftc8inx 4814 28 similar similar JJ cord-010092-uftc8inx 4814 29 levels level NNS cord-010092-uftc8inx 4814 30 in in IN cord-010092-uftc8inx 4814 31 the the DT cord-010092-uftc8inx 4814 32 two two CD cord-010092-uftc8inx 4814 33 groups group NNS cord-010092-uftc8inx 4814 34 ( ( -LRB- cord-010092-uftc8inx 4814 35 P p NN cord-010092-uftc8inx 4814 36 > > XX cord-010092-uftc8inx 4814 37 0.05 0.05 CD cord-010092-uftc8inx 4814 38 ) ) -RRB- cord-010092-uftc8inx 4814 39 . . . cord-010092-uftc8inx 4815 1 The the DT cord-010092-uftc8inx 4815 2 b b NN cord-010092-uftc8inx 4815 3 - - HYPH cord-010092-uftc8inx 4815 4 thalhet thalhet NN cord-010092-uftc8inx 4815 5 and and CC cord-010092-uftc8inx 4815 6 control control VB cord-010092-uftc8inx 4815 7 biological biological JJ cord-010092-uftc8inx 4815 8 networks network NNS cord-010092-uftc8inx 4815 9 showed show VBD cord-010092-uftc8inx 4815 10 insignificant insignificant JJ cord-010092-uftc8inx 4815 11 variations variation NNS cord-010092-uftc8inx 4815 12 in in IN cord-010092-uftc8inx 4815 13 respect respect NN cord-010092-uftc8inx 4815 14 to to IN cord-010092-uftc8inx 4815 15 the the DT cord-010092-uftc8inx 4815 16 amount amount NN cord-010092-uftc8inx 4815 17 of of IN cord-010092-uftc8inx 4815 18 connections connection NNS cord-010092-uftc8inx 4815 19 and and CC cord-010092-uftc8inx 4815 20 their -PRON- PRP$ cord-010092-uftc8inx 4815 21 hub hub NN cord-010092-uftc8inx 4815 22 profiles profile NNS cord-010092-uftc8inx 4815 23 . . . cord-010092-uftc8inx 4816 1 However however RB cord-010092-uftc8inx 4816 2 , , , cord-010092-uftc8inx 4816 3 differences difference NNS cord-010092-uftc8inx 4816 4 were be VBD cord-010092-uftc8inx 4816 5 observed observe VBN cord-010092-uftc8inx 4816 6 regarding regard VBG cord-010092-uftc8inx 4816 7 the the DT cord-010092-uftc8inx 4816 8 number number NN cord-010092-uftc8inx 4816 9 or or CC cord-010092-uftc8inx 4816 10 type type NN cord-010092-uftc8inx 4816 11 of of IN cord-010092-uftc8inx 4816 12 connections connection NNS cord-010092-uftc8inx 4816 13 , , , cord-010092-uftc8inx 4816 14 or or CC cord-010092-uftc8inx 4816 15 even even RB cord-010092-uftc8inx 4816 16 their -PRON- PRP$ cord-010092-uftc8inx 4816 17 topology topology NN cord-010092-uftc8inx 4816 18 in in IN cord-010092-uftc8inx 4816 19 the the DT cord-010092-uftc8inx 4816 20 network network NN cord-010092-uftc8inx 4816 21 , , , cord-010092-uftc8inx 4816 22 in in IN cord-010092-uftc8inx 4816 23 the the DT cord-010092-uftc8inx 4816 24 cluster cluster NN cord-010092-uftc8inx 4816 25 of of IN cord-010092-uftc8inx 4816 26 lipids lipid NNS cord-010092-uftc8inx 4816 27 ( ( -LRB- cord-010092-uftc8inx 4816 28 triglycerides triglyceride NNS cord-010092-uftc8inx 4816 29 , , , cord-010092-uftc8inx 4816 30 LDL LDL NNP cord-010092-uftc8inx 4816 31 etc etc FW cord-010092-uftc8inx 4816 32 ) ) -RRB- cord-010092-uftc8inx 4816 33 , , , cord-010092-uftc8inx 4816 34 nitric nitric JJ cord-010092-uftc8inx 4816 35 oxide oxide NN cord-010092-uftc8inx 4816 36 , , , cord-010092-uftc8inx 4816 37 clusterin clusterin NNP cord-010092-uftc8inx 4816 38 , , , cord-010092-uftc8inx 4816 39 carbonylated carbonylated JJ cord-010092-uftc8inx 4816 40 plasma plasma NN cord-010092-uftc8inx 4816 41 proteins protein NNS cord-010092-uftc8inx 4816 42 and and CC cord-010092-uftc8inx 4816 43 RBC RBC NNP cord-010092-uftc8inx 4816 44 osmotic osmotic JJ cord-010092-uftc8inx 4816 45 fragility fragility NN cord-010092-uftc8inx 4816 46 ( ( -LRB- cord-010092-uftc8inx 4816 47 correlated correlate VBN cord-010092-uftc8inx 4816 48 with with IN cord-010092-uftc8inx 4816 49 the the DT cord-010092-uftc8inx 4816 50 concentration concentration NN cord-010092-uftc8inx 4816 51 of of IN cord-010092-uftc8inx 4816 52 electrolytes electrolyte NNS cord-010092-uftc8inx 4816 53 selectively selectively RB cord-010092-uftc8inx 4816 54 in in IN cord-010092-uftc8inx 4816 55 b b NNP cord-010092-uftc8inx 4816 56 - - HYPH cord-010092-uftc8inx 4816 57 thal thal NNP cord-010092-uftc8inx 4816 58 - - HYPH cord-010092-uftc8inx 4816 59 het het NNP cord-010092-uftc8inx 4816 60 donors donor NNS cord-010092-uftc8inx 4816 61 ) ) -RRB- cord-010092-uftc8inx 4816 62 between between IN cord-010092-uftc8inx 4816 63 the the DT cord-010092-uftc8inx 4816 64 two two CD cord-010092-uftc8inx 4816 65 groups group NNS cord-010092-uftc8inx 4816 66 . . . cord-010092-uftc8inx 4817 1 Summary Summary NNP cord-010092-uftc8inx 4817 2 / / SYM cord-010092-uftc8inx 4817 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 4817 4 : : : cord-010092-uftc8inx 4818 1 b b LS cord-010092-uftc8inx 4818 2 - - : cord-010092-uftc8inx 4818 3 thal thal NNP cord-010092-uftc8inx 4818 4 - - HYPH cord-010092-uftc8inx 4818 5 het het NNP cord-010092-uftc8inx 4818 6 who who WP cord-010092-uftc8inx 4818 7 meet meet VBP cord-010092-uftc8inx 4818 8 the the DT cord-010092-uftc8inx 4818 9 criteria criterion NNS cord-010092-uftc8inx 4818 10 for for IN cord-010092-uftc8inx 4818 11 blood blood NN cord-010092-uftc8inx 4818 12 donation donation NN cord-010092-uftc8inx 4818 13 are be VBP cord-010092-uftc8inx 4818 14 a a DT cord-010092-uftc8inx 4818 15 non non JJ cord-010092-uftc8inx 4818 16 - - JJ cord-010092-uftc8inx 4818 17 negligible negligible JJ cord-010092-uftc8inx 4818 18 sub sub NN cord-010092-uftc8inx 4818 19 - - JJ cord-010092-uftc8inx 4818 20 group group NN cord-010092-uftc8inx 4818 21 of of IN cord-010092-uftc8inx 4818 22 the the DT cord-010092-uftc8inx 4818 23 total total JJ cord-010092-uftc8inx 4818 24 donor donor NN cord-010092-uftc8inx 4818 25 population population NN cord-010092-uftc8inx 4818 26 in in IN cord-010092-uftc8inx 4818 27 Greece Greece NNP cord-010092-uftc8inx 4818 28 . . . cord-010092-uftc8inx 4819 1 They -PRON- PRP cord-010092-uftc8inx 4819 2 exhibit exhibit VBP cord-010092-uftc8inx 4819 3 several several JJ cord-010092-uftc8inx 4819 4 similarities similarity NNS cord-010092-uftc8inx 4819 5 to to IN cord-010092-uftc8inx 4819 6 the the DT cord-010092-uftc8inx 4819 7 general general JJ cord-010092-uftc8inx 4819 8 cohort cohort NN cord-010092-uftc8inx 4819 9 , , , cord-010092-uftc8inx 4819 10 but but CC cord-010092-uftc8inx 4819 11 differ differ VBP cord-010092-uftc8inx 4819 12 in in IN cord-010092-uftc8inx 4819 13 fine fine JJ cord-010092-uftc8inx 4819 14 characteristics characteristic NNS cord-010092-uftc8inx 4819 15 of of IN cord-010092-uftc8inx 4819 16 RBC RBC NNP cord-010092-uftc8inx 4819 17 physiology physiology NN cord-010092-uftc8inx 4819 18 , , , cord-010092-uftc8inx 4819 19 including include VBG cord-010092-uftc8inx 4819 20 resistance resistance NN cord-010092-uftc8inx 4819 21 to to IN cord-010092-uftc8inx 4819 22 hemolysis hemolysis NN cord-010092-uftc8inx 4819 23 and and CC cord-010092-uftc8inx 4819 24 extracellular extracellular JJ cord-010092-uftc8inx 4819 25 antioxidant antioxidant JJ cord-010092-uftc8inx 4819 26 capacity capacity NN cord-010092-uftc8inx 4819 27 . . . cord-010092-uftc8inx 4820 1 The the DT cord-010092-uftc8inx 4820 2 differential differential JJ cord-010092-uftc8inx 4820 3 network network NN cord-010092-uftc8inx 4820 4 profile profile NN cord-010092-uftc8inx 4820 5 of of IN cord-010092-uftc8inx 4820 6 hematological hematological JJ cord-010092-uftc8inx 4820 7 and and CC cord-010092-uftc8inx 4820 8 redox redox JJ cord-010092-uftc8inx 4820 9 parameters parameter NNS cord-010092-uftc8inx 4820 10 may may MD cord-010092-uftc8inx 4820 11 be be VB cord-010092-uftc8inx 4820 12 important important JJ cord-010092-uftc8inx 4820 13 in in IN cord-010092-uftc8inx 4820 14 respect respect NN cord-010092-uftc8inx 4820 15 to to IN cord-010092-uftc8inx 4820 16 the the DT cord-010092-uftc8inx 4820 17 subsequent subsequent JJ cord-010092-uftc8inx 4820 18 blood blood NN cord-010092-uftc8inx 4820 19 processing processing NN cord-010092-uftc8inx 4820 20 and and CC cord-010092-uftc8inx 4820 21 storage storage NN cord-010092-uftc8inx 4820 22 of of IN cord-010092-uftc8inx 4820 23 b b NN cord-010092-uftc8inx 4820 24 - - HYPH cord-010092-uftc8inx 4820 25 thal thal NNP cord-010092-uftc8inx 4820 26 - - HYPH cord-010092-uftc8inx 4820 27 het het NNP cord-010092-uftc8inx 4820 28 erythrocytes erythrocyte NNS cord-010092-uftc8inx 4820 29 for for IN cord-010092-uftc8inx 4820 30 transfusion transfusion NN cord-010092-uftc8inx 4820 31 purposes purpose NNS cord-010092-uftc8inx 4820 32 . . . cord-010092-uftc8inx 4821 1 Background background NN cord-010092-uftc8inx 4821 2 : : : cord-010092-uftc8inx 4822 1 Blood blood NN cord-010092-uftc8inx 4822 2 service service NN cord-010092-uftc8inx 4822 3 in in IN cord-010092-uftc8inx 4822 4 Poland Poland NNP cord-010092-uftc8inx 4822 5 is be VBZ cord-010092-uftc8inx 4822 6 based base VBN cord-010092-uftc8inx 4822 7 on on IN cord-010092-uftc8inx 4822 8 voluntary voluntary JJ cord-010092-uftc8inx 4822 9 and and CC cord-010092-uftc8inx 4822 10 non non JJ cord-010092-uftc8inx 4822 11 - - JJ cord-010092-uftc8inx 4822 12 remunerated remunerated JJ cord-010092-uftc8inx 4822 13 donations donation NNS cord-010092-uftc8inx 4822 14 . . . cord-010092-uftc8inx 4823 1 Regional Regional NNP cord-010092-uftc8inx 4823 2 Blood Blood NNP cord-010092-uftc8inx 4823 3 Donor Donor NNP cord-010092-uftc8inx 4823 4 Centre Centre NNP cord-010092-uftc8inx 4823 5 in in IN cord-010092-uftc8inx 4823 6 Poznan Poznan NNP cord-010092-uftc8inx 4823 7 as as RB cord-010092-uftc8inx 4823 8 well well RB cord-010092-uftc8inx 4823 9 as as IN cord-010092-uftc8inx 4823 10 other other JJ cord-010092-uftc8inx 4823 11 regional regional JJ cord-010092-uftc8inx 4823 12 centres centre NNS cord-010092-uftc8inx 4823 13 ( ( -LRB- cord-010092-uftc8inx 4823 14 total total NN cord-010092-uftc8inx 4823 15 of of IN cord-010092-uftc8inx 4823 16 23 23 CD cord-010092-uftc8inx 4823 17 ) ) -RRB- cord-010092-uftc8inx 4823 18 are be VBP cord-010092-uftc8inx 4823 19 the the DT cord-010092-uftc8inx 4823 20 only only JJ cord-010092-uftc8inx 4823 21 entities entity NNS cord-010092-uftc8inx 4823 22 authorized authorize VBN cord-010092-uftc8inx 4823 23 to to TO cord-010092-uftc8inx 4823 24 collect collect VB cord-010092-uftc8inx 4823 25 , , , cord-010092-uftc8inx 4823 26 process process NN cord-010092-uftc8inx 4823 27 , , , cord-010092-uftc8inx 4823 28 store store VB cord-010092-uftc8inx 4823 29 and and CC cord-010092-uftc8inx 4823 30 distribute distribute VB cord-010092-uftc8inx 4823 31 blood blood NN cord-010092-uftc8inx 4823 32 and and CC cord-010092-uftc8inx 4823 33 its -PRON- PRP$ cord-010092-uftc8inx 4823 34 components component NNS cord-010092-uftc8inx 4823 35 to to IN cord-010092-uftc8inx 4823 36 hospitals hospital NNS cord-010092-uftc8inx 4823 37 in in IN cord-010092-uftc8inx 4823 38 the the DT cord-010092-uftc8inx 4823 39 region region NN cord-010092-uftc8inx 4823 40 of of IN cord-010092-uftc8inx 4823 41 their -PRON- PRP$ cord-010092-uftc8inx 4823 42 activity activity NN cord-010092-uftc8inx 4823 43 but but CC cord-010092-uftc8inx 4823 44 they -PRON- PRP cord-010092-uftc8inx 4823 45 are be VBP cord-010092-uftc8inx 4823 46 also also RB cord-010092-uftc8inx 4823 47 responsible responsible JJ cord-010092-uftc8inx 4823 48 to to TO cord-010092-uftc8inx 4823 49 provide provide VB cord-010092-uftc8inx 4823 50 sufficient sufficient JJ cord-010092-uftc8inx 4823 51 amounts amount NNS cord-010092-uftc8inx 4823 52 of of IN cord-010092-uftc8inx 4823 53 blood blood NN cord-010092-uftc8inx 4823 54 and and CC cord-010092-uftc8inx 4823 55 its -PRON- PRP$ cord-010092-uftc8inx 4823 56 components component NNS cord-010092-uftc8inx 4823 57 . . . cord-010092-uftc8inx 4824 1 Regional Regional NNP cord-010092-uftc8inx 4824 2 Blood Blood NNP cord-010092-uftc8inx 4824 3 Donor Donor NNP cord-010092-uftc8inx 4824 4 Centre Centre NNP cord-010092-uftc8inx 4824 5 in in IN cord-010092-uftc8inx 4824 6 Poznan Poznan NNP cord-010092-uftc8inx 4824 7 is be VBZ cord-010092-uftc8inx 4824 8 one one CD cord-010092-uftc8inx 4824 9 of of IN cord-010092-uftc8inx 4824 10 the the DT cord-010092-uftc8inx 4824 11 largest large JJS cord-010092-uftc8inx 4824 12 blood blood NN cord-010092-uftc8inx 4824 13 centers center NNS cord-010092-uftc8inx 4824 14 in in IN cord-010092-uftc8inx 4824 15 Poland Poland NNP cord-010092-uftc8inx 4824 16 with with IN cord-010092-uftc8inx 4824 17 the the DT cord-010092-uftc8inx 4824 18 total total JJ cord-010092-uftc8inx 4824 19 number number NN cord-010092-uftc8inx 4824 20 of of IN cord-010092-uftc8inx 4824 21 donations donation NNS cord-010092-uftc8inx 4824 22 exceeding exceed VBG cord-010092-uftc8inx 4824 23 100,000 100,000 CD cord-010092-uftc8inx 4824 24 per per IN cord-010092-uftc8inx 4824 25 year year NN cord-010092-uftc8inx 4824 26 . . . cord-010092-uftc8inx 4825 1 In in IN cord-010092-uftc8inx 4825 2 the the DT cord-010092-uftc8inx 4825 3 recent recent JJ cord-010092-uftc8inx 4825 4 years year NNS cord-010092-uftc8inx 4825 5 we -PRON- PRP cord-010092-uftc8inx 4825 6 have have VBP cord-010092-uftc8inx 4825 7 observed observe VBN cord-010092-uftc8inx 4825 8 a a DT cord-010092-uftc8inx 4825 9 growing grow VBG cord-010092-uftc8inx 4825 10 popularity popularity NN cord-010092-uftc8inx 4825 11 of of IN cord-010092-uftc8inx 4825 12 tattoos tattoo NNS cord-010092-uftc8inx 4825 13 among among IN cord-010092-uftc8inx 4825 14 various various JJ cord-010092-uftc8inx 4825 15 age age NN cord-010092-uftc8inx 4825 16 groups group NNS cord-010092-uftc8inx 4825 17 as as RB cord-010092-uftc8inx 4825 18 well well RB cord-010092-uftc8inx 4825 19 as as IN cord-010092-uftc8inx 4825 20 among among IN cord-010092-uftc8inx 4825 21 people people NNS cord-010092-uftc8inx 4825 22 registering register VBG cord-010092-uftc8inx 4825 23 to to TO cord-010092-uftc8inx 4825 24 donate donate VB cord-010092-uftc8inx 4825 25 blood blood NN cord-010092-uftc8inx 4825 26 ( ( -LRB- cord-010092-uftc8inx 4825 27 first first JJ cord-010092-uftc8inx 4825 28 time time NN cord-010092-uftc8inx 4825 29 and and CC cord-010092-uftc8inx 4825 30 repeat repeat VB cord-010092-uftc8inx 4825 31 donors donor NNS cord-010092-uftc8inx 4825 32 ) ) -RRB- cord-010092-uftc8inx 4826 1 hence hence RB cord-010092-uftc8inx 4826 2 , , , cord-010092-uftc8inx 4826 3 it -PRON- PRP cord-010092-uftc8inx 4826 4 is be VBZ cord-010092-uftc8inx 4826 5 critical critical JJ cord-010092-uftc8inx 4826 6 to to TO cord-010092-uftc8inx 4826 7 introduce introduce VB cord-010092-uftc8inx 4826 8 suitable suitable JJ cord-010092-uftc8inx 4826 9 measures measure NNS cord-010092-uftc8inx 4826 10 to to TO cord-010092-uftc8inx 4826 11 ensure ensure VB cord-010092-uftc8inx 4826 12 the the DT cord-010092-uftc8inx 4826 13 safety safety NN cord-010092-uftc8inx 4826 14 of of IN cord-010092-uftc8inx 4826 15 blood blood NN cord-010092-uftc8inx 4826 16 and and CC cord-010092-uftc8inx 4826 17 its -PRON- PRP$ cord-010092-uftc8inx 4826 18 components component NNS cord-010092-uftc8inx 4826 19 . . . cord-010092-uftc8inx 4827 1 Aims aim VBZ cord-010092-uftc8inx 4827 2 : : : cord-010092-uftc8inx 4828 1 The the DT cord-010092-uftc8inx 4828 2 aim aim NN cord-010092-uftc8inx 4828 3 was be VBD cord-010092-uftc8inx 4828 4 to to TO cord-010092-uftc8inx 4828 5 analyse analyse VB cord-010092-uftc8inx 4828 6 the the DT cord-010092-uftc8inx 4828 7 correlation correlation NN cord-010092-uftc8inx 4828 8 between between IN cord-010092-uftc8inx 4828 9 the the DT cord-010092-uftc8inx 4828 10 increasing increase VBG cord-010092-uftc8inx 4828 11 number number NN cord-010092-uftc8inx 4828 12 of of IN cord-010092-uftc8inx 4828 13 donors donor NNS cord-010092-uftc8inx 4828 14 deferred defer VBN cord-010092-uftc8inx 4828 15 from from IN cord-010092-uftc8inx 4828 16 donating donate VBG cord-010092-uftc8inx 4828 17 blood blood NN cord-010092-uftc8inx 4828 18 due due IN cord-010092-uftc8inx 4828 19 to to IN cord-010092-uftc8inx 4828 20 having have VBG cord-010092-uftc8inx 4828 21 tattoos tattoo NNS cord-010092-uftc8inx 4828 22 made make VBN cord-010092-uftc8inx 4828 23 and and CC cord-010092-uftc8inx 4828 24 the the DT cord-010092-uftc8inx 4828 25 number number NN cord-010092-uftc8inx 4828 26 of of IN cord-010092-uftc8inx 4828 27 recorded record VBN cord-010092-uftc8inx 4828 28 confirmed confirm VBN cord-010092-uftc8inx 4828 29 HCV HCV NNP cord-010092-uftc8inx 4828 30 infections infection NNS cord-010092-uftc8inx 4828 31 and and CC cord-010092-uftc8inx 4828 32 the the DT cord-010092-uftc8inx 4828 33 effect effect NN cord-010092-uftc8inx 4828 34 it -PRON- PRP cord-010092-uftc8inx 4828 35 may may MD cord-010092-uftc8inx 4828 36 have have VB cord-010092-uftc8inx 4828 37 on on IN cord-010092-uftc8inx 4828 38 the the DT cord-010092-uftc8inx 4828 39 safety safety NN cord-010092-uftc8inx 4828 40 of of IN cord-010092-uftc8inx 4828 41 blood blood NN cord-010092-uftc8inx 4828 42 and and CC cord-010092-uftc8inx 4828 43 its -PRON- PRP$ cord-010092-uftc8inx 4828 44 components component NNS cord-010092-uftc8inx 4828 45 . . . cord-010092-uftc8inx 4829 1 Methods method NNS cord-010092-uftc8inx 4829 2 : : : cord-010092-uftc8inx 4829 3 The the DT cord-010092-uftc8inx 4829 4 analysis analysis NN cord-010092-uftc8inx 4829 5 was be VBD cord-010092-uftc8inx 4829 6 made make VBN cord-010092-uftc8inx 4829 7 using use VBG cord-010092-uftc8inx 4829 8 the the DT cord-010092-uftc8inx 4829 9 data datum NNS cord-010092-uftc8inx 4829 10 for for IN cord-010092-uftc8inx 4829 11 the the DT cord-010092-uftc8inx 4829 12 years year NNS cord-010092-uftc8inx 4829 13 2010 2010 CD cord-010092-uftc8inx 4829 14 - - SYM cord-010092-uftc8inx 4829 15 2017 2017 CD cord-010092-uftc8inx 4829 16 obtained obtain VBN cord-010092-uftc8inx 4829 17 from from IN cord-010092-uftc8inx 4829 18 the the DT cord-010092-uftc8inx 4829 19 computer computer NN cord-010092-uftc8inx 4829 20 system system NN cord-010092-uftc8inx 4829 21 ' ' '' cord-010092-uftc8inx 4829 22 Blood Blood NNP cord-010092-uftc8inx 4829 23 Bank Bank NNP cord-010092-uftc8inx 4829 24 ' ' '' cord-010092-uftc8inx 4829 25 which which WDT cord-010092-uftc8inx 4829 26 is be VBZ cord-010092-uftc8inx 4829 27 in in IN cord-010092-uftc8inx 4829 28 operation operation NN cord-010092-uftc8inx 4829 29 in in IN cord-010092-uftc8inx 4829 30 Regional Regional NNP cord-010092-uftc8inx 4829 31 Blood Blood NNP cord-010092-uftc8inx 4829 32 Centre Centre NNP cord-010092-uftc8inx 4829 33 in in IN cord-010092-uftc8inx 4829 34 Poznan Poznan NNP cord-010092-uftc8inx 4829 35 , , , cord-010092-uftc8inx 4829 36 Poland Poland NNP cord-010092-uftc8inx 4829 37 . . . cord-010092-uftc8inx 4830 1 We -PRON- PRP cord-010092-uftc8inx 4830 2 have have VBP cord-010092-uftc8inx 4830 3 analysed analyse VBN cord-010092-uftc8inx 4830 4 the the DT cord-010092-uftc8inx 4830 5 total total JJ cord-010092-uftc8inx 4830 6 number number NN cord-010092-uftc8inx 4830 7 of of IN cord-010092-uftc8inx 4830 8 deferrals deferral NNS cord-010092-uftc8inx 4830 9 of of IN cord-010092-uftc8inx 4830 10 donors donor NNS cord-010092-uftc8inx 4830 11 due due JJ cord-010092-uftc8inx 4830 12 to to IN cord-010092-uftc8inx 4830 13 recently recently RB cord-010092-uftc8inx 4830 14 acquired acquire VBN cord-010092-uftc8inx 4830 15 tattoo tattoo NN cord-010092-uftc8inx 4830 16 and and CC cord-010092-uftc8inx 4830 17 the the DT cord-010092-uftc8inx 4830 18 total total JJ cord-010092-uftc8inx 4830 19 number number NN cord-010092-uftc8inx 4830 20 of of IN cord-010092-uftc8inx 4830 21 recorded record VBN cord-010092-uftc8inx 4830 22 confirmed confirm VBN cord-010092-uftc8inx 4830 23 hepatitis hepatitis NN cord-010092-uftc8inx 4830 24 C C NNP cord-010092-uftc8inx 4830 25 infections infection NNS cord-010092-uftc8inx 4830 26 . . . cord-010092-uftc8inx 4831 1 We -PRON- PRP cord-010092-uftc8inx 4831 2 must must MD cord-010092-uftc8inx 4831 3 note note VB cord-010092-uftc8inx 4831 4 that that IN cord-010092-uftc8inx 4831 5 the the DT cord-010092-uftc8inx 4831 6 category category NN cord-010092-uftc8inx 4831 7 of of IN cord-010092-uftc8inx 4831 8 temporary temporary JJ cord-010092-uftc8inx 4831 9 deferrals deferral NNS cord-010092-uftc8inx 4831 10 due due JJ cord-010092-uftc8inx 4831 11 to to IN cord-010092-uftc8inx 4831 12 tattoos tattoo NNS cord-010092-uftc8inx 4831 13 is be VBZ cord-010092-uftc8inx 4831 14 a a DT cord-010092-uftc8inx 4831 15 broad broad JJ cord-010092-uftc8inx 4831 16 one one NN cord-010092-uftc8inx 4831 17 : : : cord-010092-uftc8inx 4831 18 it -PRON- PRP cord-010092-uftc8inx 4831 19 includes include VBZ cord-010092-uftc8inx 4831 20 so so RB cord-010092-uftc8inx 4831 21 called call VBN cord-010092-uftc8inx 4831 22 regular regular JJ cord-010092-uftc8inx 4831 23 ' ' `` cord-010092-uftc8inx 4831 24 artistic artistic JJ cord-010092-uftc8inx 4831 25 ' ' '' cord-010092-uftc8inx 4831 26 tattoos tattoo NNS cord-010092-uftc8inx 4831 27 , , , cord-010092-uftc8inx 4831 28 permanent permanent JJ cord-010092-uftc8inx 4831 29 make make VB cord-010092-uftc8inx 4831 30 - - HYPH cord-010092-uftc8inx 4831 31 up up RP cord-010092-uftc8inx 4831 32 procedures procedure NNS cord-010092-uftc8inx 4831 33 as as RB cord-010092-uftc8inx 4831 34 well well RB cord-010092-uftc8inx 4831 35 as as IN cord-010092-uftc8inx 4831 36 medical medical JJ cord-010092-uftc8inx 4831 37 tattoos tattoo NNS cord-010092-uftc8inx 4831 38 . . . cord-010092-uftc8inx 4832 1 Results result NNS cord-010092-uftc8inx 4832 2 : : : cord-010092-uftc8inx 4833 1 We -PRON- PRP cord-010092-uftc8inx 4833 2 have have VBP cord-010092-uftc8inx 4833 3 recorded record VBN cord-010092-uftc8inx 4833 4 a a DT cord-010092-uftc8inx 4833 5 significant significant JJ cord-010092-uftc8inx 4833 6 increase increase NN cord-010092-uftc8inx 4833 7 in in IN cord-010092-uftc8inx 4833 8 number number NN cord-010092-uftc8inx 4833 9 of of IN cord-010092-uftc8inx 4833 10 deferrals deferral NNS cord-010092-uftc8inx 4833 11 due due JJ cord-010092-uftc8inx 4833 12 to to IN cord-010092-uftc8inx 4833 13 tattoos tattoo NNS cord-010092-uftc8inx 4833 14 from from IN cord-010092-uftc8inx 4833 15 400 400 CD cord-010092-uftc8inx 4833 16 in in IN cord-010092-uftc8inx 4833 17 2010 2010 CD cord-010092-uftc8inx 4833 18 to to IN cord-010092-uftc8inx 4833 19 716 716 CD cord-010092-uftc8inx 4833 20 in in IN cord-010092-uftc8inx 4833 21 2017 2017 CD cord-010092-uftc8inx 4833 22 ( ( -LRB- cord-010092-uftc8inx 4833 23 +79 +79 CD cord-010092-uftc8inx 4833 24 % % NN cord-010092-uftc8inx 4833 25 ) ) -RRB- cord-010092-uftc8inx 4833 26 . . . cord-010092-uftc8inx 4834 1 In in IN cord-010092-uftc8inx 4834 2 the the DT cord-010092-uftc8inx 4834 3 group group NN cord-010092-uftc8inx 4834 4 of of IN cord-010092-uftc8inx 4834 5 male male JJ cord-010092-uftc8inx 4834 6 donors donor NNS cord-010092-uftc8inx 4834 7 this this DT cord-010092-uftc8inx 4834 8 trend trend NN cord-010092-uftc8inx 4834 9 remained remain VBD cord-010092-uftc8inx 4834 10 rather rather RB cord-010092-uftc8inx 4834 11 stable stable JJ cord-010092-uftc8inx 4834 12 with with IN cord-010092-uftc8inx 4834 13 a a DT cord-010092-uftc8inx 4834 14 slight slight JJ cord-010092-uftc8inx 4834 15 decrease decrease NN cord-010092-uftc8inx 4834 16 : : : cord-010092-uftc8inx 4834 17 from from IN cord-010092-uftc8inx 4834 18 181 181 CD cord-010092-uftc8inx 4834 19 in in IN cord-010092-uftc8inx 4834 20 2011 2011 CD cord-010092-uftc8inx 4834 21 to to IN cord-010092-uftc8inx 4834 22 151 151 CD cord-010092-uftc8inx 4834 23 in in IN cord-010092-uftc8inx 4834 24 2017 2017 CD cord-010092-uftc8inx 4834 25 ( ( -LRB- cord-010092-uftc8inx 4834 26 À16.6 à16.6 CD cord-010092-uftc8inx 4834 27 % % NN cord-010092-uftc8inx 4834 28 ) ) -RRB- cord-010092-uftc8inx 4834 29 . . . cord-010092-uftc8inx 4835 1 In in IN cord-010092-uftc8inx 4835 2 the the DT cord-010092-uftc8inx 4835 3 group group NN cord-010092-uftc8inx 4835 4 of of IN cord-010092-uftc8inx 4835 5 female female JJ cord-010092-uftc8inx 4835 6 donors donor NNS cord-010092-uftc8inx 4835 7 the the DT cord-010092-uftc8inx 4835 8 growth growth NN cord-010092-uftc8inx 4835 9 was be VBD cord-010092-uftc8inx 4835 10 more more RBR cord-010092-uftc8inx 4835 11 prominent prominent JJ cord-010092-uftc8inx 4835 12 : : : cord-010092-uftc8inx 4835 13 from from IN cord-010092-uftc8inx 4835 14 219 219 CD cord-010092-uftc8inx 4835 15 in in IN cord-010092-uftc8inx 4835 16 2010 2010 CD cord-010092-uftc8inx 4835 17 to to IN cord-010092-uftc8inx 4835 18 565 565 CD cord-010092-uftc8inx 4835 19 in in IN cord-010092-uftc8inx 4835 20 2017 2017 CD cord-010092-uftc8inx 4835 21 ( ( -LRB- cord-010092-uftc8inx 4835 22 +158 +158 CD cord-010092-uftc8inx 4835 23 % % NN cord-010092-uftc8inx 4835 24 ) ) -RRB- cord-010092-uftc8inx 4835 25 . . . cord-010092-uftc8inx 4836 1 In in IN cord-010092-uftc8inx 4836 2 terms term NNS cord-010092-uftc8inx 4836 3 of of IN cord-010092-uftc8inx 4836 4 the the DT cord-010092-uftc8inx 4836 5 recorded record VBN cord-010092-uftc8inx 4836 6 confirmed confirm VBD cord-010092-uftc8inx 4836 7 HCV HCV NNP cord-010092-uftc8inx 4836 8 infections infection NNS cord-010092-uftc8inx 4836 9 a a DT cord-010092-uftc8inx 4836 10 downward downward JJ cord-010092-uftc8inx 4836 11 trend trend NN cord-010092-uftc8inx 4836 12 can can MD cord-010092-uftc8inx 4836 13 be be VB cord-010092-uftc8inx 4836 14 observed observe VBN cord-010092-uftc8inx 4836 15 : : : cord-010092-uftc8inx 4836 16 from from IN cord-010092-uftc8inx 4836 17 63 63 CD cord-010092-uftc8inx 4836 18 in in IN cord-010092-uftc8inx 4836 19 2010 2010 CD cord-010092-uftc8inx 4836 20 to to IN cord-010092-uftc8inx 4836 21 16 16 CD cord-010092-uftc8inx 4836 22 in in IN cord-010092-uftc8inx 4836 23 2017 2017 CD cord-010092-uftc8inx 4836 24 ( ( -LRB- cord-010092-uftc8inx 4836 25 À74.6 à74.6 CD cord-010092-uftc8inx 4836 26 % % NN cord-010092-uftc8inx 4836 27 ) ) -RRB- cord-010092-uftc8inx 4836 28 . . . cord-010092-uftc8inx 4837 1 In in IN cord-010092-uftc8inx 4837 2 the the DT cord-010092-uftc8inx 4837 3 group group NN cord-010092-uftc8inx 4837 4 of of IN cord-010092-uftc8inx 4837 5 male male JJ cord-010092-uftc8inx 4837 6 donors donor NNS cord-010092-uftc8inx 4837 7 from from IN cord-010092-uftc8inx 4837 8 43 43 CD cord-010092-uftc8inx 4837 9 in in IN cord-010092-uftc8inx 4837 10 2019 2019 CD cord-010092-uftc8inx 4837 11 to to IN cord-010092-uftc8inx 4837 12 12 12 CD cord-010092-uftc8inx 4837 13 in in IN cord-010092-uftc8inx 4837 14 2017 2017 CD cord-010092-uftc8inx 4837 15 ( ( -LRB- cord-010092-uftc8inx 4837 16 À72 À72 NNP cord-010092-uftc8inx 4837 17 % % NN cord-010092-uftc8inx 4837 18 ) ) -RRB- cord-010092-uftc8inx 4837 19 , , , cord-010092-uftc8inx 4837 20 in in IN cord-010092-uftc8inx 4837 21 the the DT cord-010092-uftc8inx 4837 22 group group NN cord-010092-uftc8inx 4837 23 of of IN cord-010092-uftc8inx 4837 24 female female JJ cord-010092-uftc8inx 4837 25 donors donor NNS cord-010092-uftc8inx 4837 26 from from IN cord-010092-uftc8inx 4837 27 20 20 CD cord-010092-uftc8inx 4837 28 in in IN cord-010092-uftc8inx 4837 29 2010 2010 CD cord-010092-uftc8inx 4837 30 to to IN cord-010092-uftc8inx 4837 31 4 4 CD cord-010092-uftc8inx 4837 32 in in IN cord-010092-uftc8inx 4837 33 2017 2017 CD cord-010092-uftc8inx 4837 34 ( ( -LRB- cord-010092-uftc8inx 4837 35 À80 À80 NNP cord-010092-uftc8inx 4837 36 % % NN cord-010092-uftc8inx 4837 37 ) ) -RRB- cord-010092-uftc8inx 4837 38 . . . cord-010092-uftc8inx 4838 1 Summary Summary NNP cord-010092-uftc8inx 4838 2 / / SYM cord-010092-uftc8inx 4838 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 4838 4 : : : cord-010092-uftc8inx 4839 1 As as IN cord-010092-uftc8inx 4839 2 we -PRON- PRP cord-010092-uftc8inx 4839 3 can can MD cord-010092-uftc8inx 4839 4 conclude conclude VB cord-010092-uftc8inx 4839 5 from from IN cord-010092-uftc8inx 4839 6 the the DT cord-010092-uftc8inx 4839 7 analysis analysis NN cord-010092-uftc8inx 4839 8 the the DT cord-010092-uftc8inx 4839 9 applied apply VBN cord-010092-uftc8inx 4839 10 policy policy NN cord-010092-uftc8inx 4839 11 of of IN cord-010092-uftc8inx 4839 12 temporary temporary JJ cord-010092-uftc8inx 4839 13 deferrals deferral NNS cord-010092-uftc8inx 4839 14 of of IN cord-010092-uftc8inx 4839 15 donors donor NNS cord-010092-uftc8inx 4839 16 with with IN cord-010092-uftc8inx 4839 17 recently recently RB cord-010092-uftc8inx 4839 18 acquired acquire VBN cord-010092-uftc8inx 4839 19 tattoos tattoo NNS cord-010092-uftc8inx 4839 20 ( ( -LRB- cord-010092-uftc8inx 4839 21 in in IN cord-010092-uftc8inx 4839 22 the the DT cord-010092-uftc8inx 4839 23 last last JJ cord-010092-uftc8inx 4839 24 6 6 CD cord-010092-uftc8inx 4839 25 months month NNS cord-010092-uftc8inx 4839 26 ) ) -RRB- cord-010092-uftc8inx 4839 27 proves prove VBZ cord-010092-uftc8inx 4839 28 to to TO cord-010092-uftc8inx 4839 29 be be VB cord-010092-uftc8inx 4839 30 a a DT cord-010092-uftc8inx 4839 31 reliable reliable JJ cord-010092-uftc8inx 4839 32 method method NN cord-010092-uftc8inx 4839 33 of of IN cord-010092-uftc8inx 4839 34 increasing increase VBG cord-010092-uftc8inx 4839 35 the the DT cord-010092-uftc8inx 4839 36 safety safety NN cord-010092-uftc8inx 4839 37 of of IN cord-010092-uftc8inx 4839 38 blood blood NN cord-010092-uftc8inx 4839 39 and and CC cord-010092-uftc8inx 4839 40 its -PRON- PRP$ cord-010092-uftc8inx 4839 41 components component NNS cord-010092-uftc8inx 4839 42 . . . cord-010092-uftc8inx 4840 1 Nevertheless nevertheless RB cord-010092-uftc8inx 4840 2 , , , cord-010092-uftc8inx 4840 3 the the DT cord-010092-uftc8inx 4840 4 current current JJ cord-010092-uftc8inx 4840 5 conduct conduct NN cord-010092-uftc8inx 4840 6 of of IN cord-010092-uftc8inx 4840 7 the the DT cord-010092-uftc8inx 4840 8 qualification qualification NN cord-010092-uftc8inx 4840 9 of of IN cord-010092-uftc8inx 4840 10 the the DT cord-010092-uftc8inx 4840 11 donors donor NNS cord-010092-uftc8inx 4840 12 which which WDT cord-010092-uftc8inx 4840 13 requires require VBZ cord-010092-uftc8inx 4840 14 a a DT cord-010092-uftc8inx 4840 15 6 6 CD cord-010092-uftc8inx 4840 16 month month NN cord-010092-uftc8inx 4840 17 deferral deferral NN cord-010092-uftc8inx 4840 18 following follow VBG cord-010092-uftc8inx 4840 19 the the DT cord-010092-uftc8inx 4840 20 new new JJ cord-010092-uftc8inx 4840 21 tattoo tattoo NN cord-010092-uftc8inx 4840 22 must must MD cord-010092-uftc8inx 4840 23 be be VB cord-010092-uftc8inx 4840 24 complemented complement VBN cord-010092-uftc8inx 4840 25 by by IN cord-010092-uftc8inx 4840 26 various various JJ cord-010092-uftc8inx 4840 27 and and CC cord-010092-uftc8inx 4840 28 numerous numerous JJ cord-010092-uftc8inx 4840 29 educational educational JJ cord-010092-uftc8inx 4840 30 activities activity NNS cord-010092-uftc8inx 4840 31 regarding regard VBG cord-010092-uftc8inx 4840 32 the the DT cord-010092-uftc8inx 4840 33 means mean NNS cord-010092-uftc8inx 4840 34 of of IN cord-010092-uftc8inx 4840 35 HCV HCV NNP cord-010092-uftc8inx 4840 36 transmission transmission NN cord-010092-uftc8inx 4840 37 ( ( -LRB- cord-010092-uftc8inx 4840 38 and and CC cord-010092-uftc8inx 4840 39 other other JJ cord-010092-uftc8inx 4840 40 bloodborne bloodborne JJ cord-010092-uftc8inx 4840 41 viruses virus NNS cord-010092-uftc8inx 4840 42 such such JJ cord-010092-uftc8inx 4840 43 as as IN cord-010092-uftc8inx 4840 44 HBV HBV NNP cord-010092-uftc8inx 4840 45 , , , cord-010092-uftc8inx 4840 46 HIV HIV NNP cord-010092-uftc8inx 4840 47 ) ) -RRB- cord-010092-uftc8inx 4840 48 and and CC cord-010092-uftc8inx 4840 49 ways way NNS cord-010092-uftc8inx 4840 50 of of IN cord-010092-uftc8inx 4840 51 protection protection NN cord-010092-uftc8inx 4840 52 from from IN cord-010092-uftc8inx 4840 53 possible possible JJ cord-010092-uftc8inx 4840 54 infections infection NNS cord-010092-uftc8inx 4840 55 . . . cord-010092-uftc8inx 4841 1 Special special JJ cord-010092-uftc8inx 4841 2 emphasis emphasis NN cord-010092-uftc8inx 4841 3 must must MD cord-010092-uftc8inx 4841 4 be be VB cord-010092-uftc8inx 4841 5 put put VBN cord-010092-uftc8inx 4841 6 on on IN cord-010092-uftc8inx 4841 7 the the DT cord-010092-uftc8inx 4841 8 group group NN cord-010092-uftc8inx 4841 9 of of IN cord-010092-uftc8inx 4841 10 female female JJ cord-010092-uftc8inx 4841 11 donors donor NNS cord-010092-uftc8inx 4841 12 as as IN cord-010092-uftc8inx 4841 13 the the DT cord-010092-uftc8inx 4841 14 growth growth NN cord-010092-uftc8inx 4841 15 of of IN cord-010092-uftc8inx 4841 16 deferrals deferral NNS cord-010092-uftc8inx 4841 17 was be VBD cord-010092-uftc8inx 4841 18 more more RBR cord-010092-uftc8inx 4841 19 prominent prominent JJ cord-010092-uftc8inx 4841 20 among among IN cord-010092-uftc8inx 4841 21 them -PRON- PRP cord-010092-uftc8inx 4841 22 . . . cord-010092-uftc8inx 4842 1 At at IN cord-010092-uftc8inx 4842 2 the the DT cord-010092-uftc8inx 4842 3 same same JJ cord-010092-uftc8inx 4842 4 time time NN cord-010092-uftc8inx 4842 5 it -PRON- PRP cord-010092-uftc8inx 4842 6 is be VBZ cord-010092-uftc8inx 4842 7 vital vital JJ cord-010092-uftc8inx 4842 8 to to TO cord-010092-uftc8inx 4842 9 ensure ensure VB cord-010092-uftc8inx 4842 10 for for IN cord-010092-uftc8inx 4842 11 constant constant JJ cord-010092-uftc8inx 4842 12 availability availability NN cord-010092-uftc8inx 4842 13 for for IN cord-010092-uftc8inx 4842 14 all all DT cord-010092-uftc8inx 4842 15 donors donor NNS cord-010092-uftc8inx 4842 16 of of IN cord-010092-uftc8inx 4842 17 well well RB cord-010092-uftc8inx 4842 18 designed design VBN cord-010092-uftc8inx 4842 19 , , , cord-010092-uftc8inx 4842 20 concise concise JJ cord-010092-uftc8inx 4842 21 educational educational JJ cord-010092-uftc8inx 4842 22 materials material NNS cord-010092-uftc8inx 4842 23 ( ( -LRB- cord-010092-uftc8inx 4842 24 hard hard JJ cord-010092-uftc8inx 4842 25 copies copy NNS cord-010092-uftc8inx 4842 26 on on IN cord-010092-uftc8inx 4842 27 the the DT cord-010092-uftc8inx 4842 28 premises premise NNS cord-010092-uftc8inx 4842 29 , , , cord-010092-uftc8inx 4842 30 articles article NNS cord-010092-uftc8inx 4842 31 , , , cord-010092-uftc8inx 4842 32 infographics infographic NNS cord-010092-uftc8inx 4842 33 , , , cord-010092-uftc8inx 4842 34 downloadables downloadable NNS cord-010092-uftc8inx 4842 35 etc etc FW cord-010092-uftc8inx 4842 36 . . . cord-010092-uftc8inx 4843 1 on on IN cord-010092-uftc8inx 4843 2 the the DT cord-010092-uftc8inx 4843 3 website website NN cord-010092-uftc8inx 4843 4 ) ) -RRB- cord-010092-uftc8inx 4843 5 . . . cord-010092-uftc8inx 4844 1 Background background NN cord-010092-uftc8inx 4844 2 : : : cord-010092-uftc8inx 4845 1 A a DT cord-010092-uftc8inx 4845 2 temporary temporary JJ cord-010092-uftc8inx 4845 3 deferral deferral NN cord-010092-uftc8inx 4845 4 has have VBZ cord-010092-uftc8inx 4845 5 a a DT cord-010092-uftc8inx 4845 6 negative negative JJ cord-010092-uftc8inx 4845 7 impact impact NN cord-010092-uftc8inx 4845 8 on on IN cord-010092-uftc8inx 4845 9 donor donor NN cord-010092-uftc8inx 4845 10 retention retention NN cord-010092-uftc8inx 4845 11 , , , cord-010092-uftc8inx 4845 12 with with IN cord-010092-uftc8inx 4845 13 many many JJ cord-010092-uftc8inx 4845 14 donors donor NNS cord-010092-uftc8inx 4845 15 failing fail VBG cord-010092-uftc8inx 4845 16 to to TO cord-010092-uftc8inx 4845 17 return return VB cord-010092-uftc8inx 4845 18 at at IN cord-010092-uftc8inx 4845 19 the the DT cord-010092-uftc8inx 4845 20 end end NN cord-010092-uftc8inx 4845 21 of of IN cord-010092-uftc8inx 4845 22 their -PRON- PRP$ cord-010092-uftc8inx 4845 23 deferral deferral NN cord-010092-uftc8inx 4845 24 period period NN cord-010092-uftc8inx 4845 25 . . . cord-010092-uftc8inx 4846 1 Anecdotal anecdotal JJ cord-010092-uftc8inx 4846 2 evidence evidence NN cord-010092-uftc8inx 4846 3 collected collect VBN cord-010092-uftc8inx 4846 4 by by IN cord-010092-uftc8inx 4846 5 the the DT cord-010092-uftc8inx 4846 6 Australian Australian NNP cord-010092-uftc8inx 4846 7 Red Red NNP cord-010092-uftc8inx 4846 8 Cross Cross NNP cord-010092-uftc8inx 4846 9 Blood Blood NNP cord-010092-uftc8inx 4846 10 Service Service NNP cord-010092-uftc8inx 4846 11 suggested suggest VBD cord-010092-uftc8inx 4846 12 that that IN cord-010092-uftc8inx 4846 13 many many JJ cord-010092-uftc8inx 4846 14 donors donor NNS cord-010092-uftc8inx 4846 15 do do VBP cord-010092-uftc8inx 4846 16 not not RB cord-010092-uftc8inx 4846 17 know know VB cord-010092-uftc8inx 4846 18 when when WRB cord-010092-uftc8inx 4846 19 they -PRON- PRP cord-010092-uftc8inx 4846 20 are be VBP cord-010092-uftc8inx 4846 21 eligible eligible JJ cord-010092-uftc8inx 4846 22 to to TO cord-010092-uftc8inx 4846 23 return return VB cord-010092-uftc8inx 4846 24 to to TO cord-010092-uftc8inx 4846 25 donate donate VB cord-010092-uftc8inx 4846 26 , , , cord-010092-uftc8inx 4846 27 suggesting suggest VBG cord-010092-uftc8inx 4846 28 that that IN cord-010092-uftc8inx 4846 29 a a DT cord-010092-uftc8inx 4846 30 reminder reminder JJ cord-010092-uftc8inx 4846 31 message message NN cord-010092-uftc8inx 4846 32 may may MD cord-010092-uftc8inx 4846 33 be be VB cord-010092-uftc8inx 4846 34 effective effective JJ cord-010092-uftc8inx 4846 35 at at IN cord-010092-uftc8inx 4846 36 promoting promote VBG cord-010092-uftc8inx 4846 37 donor donor NN cord-010092-uftc8inx 4846 38 return return NN cord-010092-uftc8inx 4846 39 once once IN cord-010092-uftc8inx 4846 40 the the DT cord-010092-uftc8inx 4846 41 deferral deferral NN cord-010092-uftc8inx 4846 42 has have VBZ cord-010092-uftc8inx 4846 43 ended end VBN cord-010092-uftc8inx 4846 44 . . . cord-010092-uftc8inx 4847 1 Aims aim VBZ cord-010092-uftc8inx 4847 2 : : : cord-010092-uftc8inx 4848 1 The the DT cord-010092-uftc8inx 4848 2 aim aim NN cord-010092-uftc8inx 4848 3 of of IN cord-010092-uftc8inx 4848 4 this this DT cord-010092-uftc8inx 4848 5 study study NN cord-010092-uftc8inx 4848 6 is be VBZ cord-010092-uftc8inx 4848 7 to to TO cord-010092-uftc8inx 4848 8 evaluate evaluate VB cord-010092-uftc8inx 4848 9 the the DT cord-010092-uftc8inx 4848 10 effectiveness effectiveness NN cord-010092-uftc8inx 4848 11 of of IN cord-010092-uftc8inx 4848 12 a a DT cord-010092-uftc8inx 4848 13 reminder reminder JJ cord-010092-uftc8inx 4848 14 message message NN cord-010092-uftc8inx 4848 15 on on IN cord-010092-uftc8inx 4848 16 the the DT cord-010092-uftc8inx 4848 17 return return NN cord-010092-uftc8inx 4848 18 rates rate NNS cord-010092-uftc8inx 4848 19 of of IN cord-010092-uftc8inx 4848 20 deferred deferred JJ cord-010092-uftc8inx 4848 21 donors donor NNS cord-010092-uftc8inx 4848 22 at at IN cord-010092-uftc8inx 4848 23 the the DT cord-010092-uftc8inx 4848 24 end end NN cord-010092-uftc8inx 4848 25 of of IN cord-010092-uftc8inx 4848 26 their -PRON- PRP$ cord-010092-uftc8inx 4848 27 deferral deferral NN cord-010092-uftc8inx 4848 28 period period NN cord-010092-uftc8inx 4848 29 . . . cord-010092-uftc8inx 4849 1 This this DT cord-010092-uftc8inx 4849 2 reminder reminder JJ cord-010092-uftc8inx 4849 3 message message NN cord-010092-uftc8inx 4849 4 notified notify VBD cord-010092-uftc8inx 4849 5 donors donor NNS cord-010092-uftc8inx 4849 6 that that IN cord-010092-uftc8inx 4849 7 their -PRON- PRP$ cord-010092-uftc8inx 4849 8 deferral deferral NN cord-010092-uftc8inx 4849 9 period period NN cord-010092-uftc8inx 4849 10 was be VBD cord-010092-uftc8inx 4849 11 ending end VBG cord-010092-uftc8inx 4849 12 and and CC cord-010092-uftc8inx 4849 13 encouraged encourage VBD cord-010092-uftc8inx 4849 14 them -PRON- PRP cord-010092-uftc8inx 4849 15 to to TO cord-010092-uftc8inx 4849 16 make make VB cord-010092-uftc8inx 4849 17 an an DT cord-010092-uftc8inx 4849 18 appointment appointment NN cord-010092-uftc8inx 4849 19 to to TO cord-010092-uftc8inx 4849 20 donate donate VB cord-010092-uftc8inx 4849 21 . . . cord-010092-uftc8inx 4850 1 This this DT cord-010092-uftc8inx 4850 2 study study NN cord-010092-uftc8inx 4850 3 also also RB cord-010092-uftc8inx 4850 4 aimed aim VBD cord-010092-uftc8inx 4850 5 to to TO cord-010092-uftc8inx 4850 6 determine determine VB cord-010092-uftc8inx 4850 7 the the DT cord-010092-uftc8inx 4850 8 most most RBS cord-010092-uftc8inx 4850 9 effective effective JJ cord-010092-uftc8inx 4850 10 time time NN cord-010092-uftc8inx 4850 11 to to TO cord-010092-uftc8inx 4850 12 send send VB cord-010092-uftc8inx 4850 13 the the DT cord-010092-uftc8inx 4850 14 message message NN cord-010092-uftc8inx 4850 15 , , , cord-010092-uftc8inx 4850 16 message message NN cord-010092-uftc8inx 4850 17 content content NN cord-010092-uftc8inx 4850 18 , , , cord-010092-uftc8inx 4850 19 and and CC cord-010092-uftc8inx 4850 20 mode mode NN cord-010092-uftc8inx 4850 21 of of IN cord-010092-uftc8inx 4850 22 communication communication NN cord-010092-uftc8inx 4850 23 ( ( -LRB- cord-010092-uftc8inx 4850 24 SMS SMS NNP cord-010092-uftc8inx 4850 25 vs vs IN cord-010092-uftc8inx 4850 26 email email NN cord-010092-uftc8inx 4850 27 ) ) -RRB- cord-010092-uftc8inx 4850 28 in in IN cord-010092-uftc8inx 4850 29 optimising optimise VBG cord-010092-uftc8inx 4850 30 donor donor NN cord-010092-uftc8inx 4850 31 retention retention NN cord-010092-uftc8inx 4850 32 post post NN cord-010092-uftc8inx 4850 33 deferral deferral NN cord-010092-uftc8inx 4850 34 . . . cord-010092-uftc8inx 4851 1 Methods method NNS cord-010092-uftc8inx 4851 2 : : : cord-010092-uftc8inx 4851 3 Three three CD cord-010092-uftc8inx 4851 4 separate separate JJ cord-010092-uftc8inx 4851 5 randomised randomised JJ cord-010092-uftc8inx 4851 6 controlled control VBN cord-010092-uftc8inx 4851 7 trials trial NNS cord-010092-uftc8inx 4851 8 were be VBD cord-010092-uftc8inx 4851 9 conducted conduct VBN cord-010092-uftc8inx 4851 10 to to TO cord-010092-uftc8inx 4851 11 answer answer VB cord-010092-uftc8inx 4851 12 these these DT cord-010092-uftc8inx 4851 13 questions question NNS cord-010092-uftc8inx 4851 14 . . . cord-010092-uftc8inx 4852 1 Data datum NNS cord-010092-uftc8inx 4852 2 on on IN cord-010092-uftc8inx 4852 3 donors donor NNS cord-010092-uftc8inx 4852 4 ' ' POS cord-010092-uftc8inx 4852 5 attempted attempt VBD cord-010092-uftc8inx 4852 6 return return NN cord-010092-uftc8inx 4852 7 behaviour behaviour NN cord-010092-uftc8inx 4852 8 and and CC cord-010092-uftc8inx 4852 9 subsequent subsequent JJ cord-010092-uftc8inx 4852 10 deferrals deferral NNS cord-010092-uftc8inx 4852 11 , , , cord-010092-uftc8inx 4852 12 appointments appointment NNS cord-010092-uftc8inx 4852 13 and and CC cord-010092-uftc8inx 4852 14 donations donation NNS cord-010092-uftc8inx 4852 15 made make VBD cord-010092-uftc8inx 4852 16 one one CD cord-010092-uftc8inx 4852 17 month month NN cord-010092-uftc8inx 4852 18 after after IN cord-010092-uftc8inx 4852 19 the the DT cord-010092-uftc8inx 4852 20 deferral deferral NN cord-010092-uftc8inx 4852 21 end end NN cord-010092-uftc8inx 4852 22 date date NN cord-010092-uftc8inx 4852 23 were be VBD cord-010092-uftc8inx 4852 24 collected collect VBN cord-010092-uftc8inx 4852 25 and and CC cord-010092-uftc8inx 4852 26 analysed analyse VBN cord-010092-uftc8inx 4852 27 . . . cord-010092-uftc8inx 4853 1 Results result NNS cord-010092-uftc8inx 4853 2 : : : cord-010092-uftc8inx 4854 1 Overall overall RB cord-010092-uftc8inx 4854 2 , , , cord-010092-uftc8inx 4854 3 18.3 18.3 CD cord-010092-uftc8inx 4854 4 % % NN cord-010092-uftc8inx 4854 5 of of IN cord-010092-uftc8inx 4854 6 donors donor NNS cord-010092-uftc8inx 4854 7 who who WP cord-010092-uftc8inx 4854 8 received receive VBD cord-010092-uftc8inx 4854 9 a a DT cord-010092-uftc8inx 4854 10 reminder reminder JJ cord-010092-uftc8inx 4854 11 message message NN cord-010092-uftc8inx 4854 12 attempted attempt VBD cord-010092-uftc8inx 4854 13 to to TO cord-010092-uftc8inx 4854 14 return return VB cord-010092-uftc8inx 4854 15 compared compare VBN cord-010092-uftc8inx 4854 16 to to IN cord-010092-uftc8inx 4854 17 12.8 12.8 CD cord-010092-uftc8inx 4854 18 % % NN cord-010092-uftc8inx 4854 19 of of IN cord-010092-uftc8inx 4854 20 donors donor NNS cord-010092-uftc8inx 4854 21 in in IN cord-010092-uftc8inx 4854 22 the the DT cord-010092-uftc8inx 4854 23 control control NN cord-010092-uftc8inx 4854 24 group group NN cord-010092-uftc8inx 4854 25 ( ( -LRB- cord-010092-uftc8inx 4854 26 P p NN cord-010092-uftc8inx 4854 27 < < XX cord-010092-uftc8inx 4854 28 0.05 0.05 CD cord-010092-uftc8inx 4854 29 ) ) -RRB- cord-010092-uftc8inx 4854 30 . . . cord-010092-uftc8inx 4855 1 Looking look VBG cord-010092-uftc8inx 4855 2 at at IN cord-010092-uftc8inx 4855 3 each each DT cord-010092-uftc8inx 4855 4 time time NN cord-010092-uftc8inx 4855 5 point point NN cord-010092-uftc8inx 4855 6 , , , cord-010092-uftc8inx 4855 7 donors donor NNS cord-010092-uftc8inx 4855 8 who who WP cord-010092-uftc8inx 4855 9 received receive VBD cord-010092-uftc8inx 4855 10 the the DT cord-010092-uftc8inx 4855 11 message message NN cord-010092-uftc8inx 4855 12 1 1 CD cord-010092-uftc8inx 4855 13 week week NN cord-010092-uftc8inx 4855 14 before before IN cord-010092-uftc8inx 4855 15 their -PRON- PRP$ cord-010092-uftc8inx 4855 16 deferral deferral NN cord-010092-uftc8inx 4855 17 ended end VBD cord-010092-uftc8inx 4855 18 were be VBD cord-010092-uftc8inx 4855 19 64 64 CD cord-010092-uftc8inx 4855 20 % % NN cord-010092-uftc8inx 4855 21 more more RBR cord-010092-uftc8inx 4855 22 likely likely JJ cord-010092-uftc8inx 4855 23 to to TO cord-010092-uftc8inx 4855 24 attempt attempt VB cord-010092-uftc8inx 4855 25 to to TO cord-010092-uftc8inx 4855 26 return return VB cord-010092-uftc8inx 4855 27 compared compare VBN cord-010092-uftc8inx 4855 28 to to IN cord-010092-uftc8inx 4855 29 the the DT cord-010092-uftc8inx 4855 30 control control NN cord-010092-uftc8inx 4855 31 group group NN cord-010092-uftc8inx 4855 32 ( ( -LRB- cord-010092-uftc8inx 4855 33 P p NN cord-010092-uftc8inx 4855 34 < < XX cord-010092-uftc8inx 4855 35 0.05 0.05 CD cord-010092-uftc8inx 4855 36 ) ) -RRB- cord-010092-uftc8inx 4855 37 . . . cord-010092-uftc8inx 4856 1 The the DT cord-010092-uftc8inx 4856 2 1 1 CD cord-010092-uftc8inx 4856 3 week week NN cord-010092-uftc8inx 4856 4 prior prior JJ cord-010092-uftc8inx 4856 5 reminder reminder NN cord-010092-uftc8inx 4856 6 message message NN cord-010092-uftc8inx 4856 7 was be VBD cord-010092-uftc8inx 4856 8 particularly particularly RB cord-010092-uftc8inx 4856 9 effective effective JJ cord-010092-uftc8inx 4856 10 with with IN cord-010092-uftc8inx 4856 11 males male NNS cord-010092-uftc8inx 4856 12 , , , cord-010092-uftc8inx 4856 13 with with IN cord-010092-uftc8inx 4856 14 30.3 30.3 CD cord-010092-uftc8inx 4856 15 % % NN cord-010092-uftc8inx 4856 16 attempting attempt VBG cord-010092-uftc8inx 4856 17 to to TO cord-010092-uftc8inx 4856 18 return return VB cord-010092-uftc8inx 4856 19 to to TO cord-010092-uftc8inx 4856 20 donate donate VB cord-010092-uftc8inx 4856 21 , , , cord-010092-uftc8inx 4856 22 compared compare VBN cord-010092-uftc8inx 4856 23 with with IN cord-010092-uftc8inx 4856 24 25.2 25.2 CD cord-010092-uftc8inx 4856 25 % % NN cord-010092-uftc8inx 4856 26 of of IN cord-010092-uftc8inx 4856 27 females female NNS cord-010092-uftc8inx 4856 28 ( ( -LRB- cord-010092-uftc8inx 4856 29 P p NN cord-010092-uftc8inx 4856 30 < < XX cord-010092-uftc8inx 4856 31 0.05 0.05 CD cord-010092-uftc8inx 4856 32 ) ) -RRB- cord-010092-uftc8inx 4856 33 . . . cord-010092-uftc8inx 4857 1 There there EX cord-010092-uftc8inx 4857 2 were be VBD cord-010092-uftc8inx 4857 3 no no DT cord-010092-uftc8inx 4857 4 significant significant JJ cord-010092-uftc8inx 4857 5 differences difference NNS cord-010092-uftc8inx 4857 6 in in IN cord-010092-uftc8inx 4857 7 the the DT cord-010092-uftc8inx 4857 8 return return NN cord-010092-uftc8inx 4857 9 rates rate NNS cord-010092-uftc8inx 4857 10 of of IN cord-010092-uftc8inx 4857 11 donors donor NNS cord-010092-uftc8inx 4857 12 who who WP cord-010092-uftc8inx 4857 13 received receive VBD cord-010092-uftc8inx 4857 14 the the DT cord-010092-uftc8inx 4857 15 recipient recipient NN cord-010092-uftc8inx 4857 16 versus versus IN cord-010092-uftc8inx 4857 17 non non JJ cord-010092-uftc8inx 4857 18 - - JJ cord-010092-uftc8inx 4857 19 recipient recipient JJ cord-010092-uftc8inx 4857 20 focused focus VBD cord-010092-uftc8inx 4857 21 message message NN cord-010092-uftc8inx 4857 22 , , , cord-010092-uftc8inx 4857 23 or or CC cord-010092-uftc8inx 4857 24 donors donor NNS cord-010092-uftc8inx 4857 25 who who WP cord-010092-uftc8inx 4857 26 received receive VBD cord-010092-uftc8inx 4857 27 the the DT cord-010092-uftc8inx 4857 28 message message NN cord-010092-uftc8inx 4857 29 via via IN cord-010092-uftc8inx 4857 30 email email NN cord-010092-uftc8inx 4857 31 or or CC cord-010092-uftc8inx 4857 32 SMS sms NN cord-010092-uftc8inx 4857 33 . . . cord-010092-uftc8inx 4858 1 Summary Summary NNP cord-010092-uftc8inx 4858 2 / / SYM cord-010092-uftc8inx 4858 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 4858 4 : : : cord-010092-uftc8inx 4859 1 A a DT cord-010092-uftc8inx 4859 2 reminder reminder JJ cord-010092-uftc8inx 4859 3 message message NN cord-010092-uftc8inx 4859 4 sent send VBN cord-010092-uftc8inx 4859 5 to to IN cord-010092-uftc8inx 4859 6 deferred deferred JJ cord-010092-uftc8inx 4859 7 donors donor NNS cord-010092-uftc8inx 4859 8 at at IN cord-010092-uftc8inx 4859 9 the the DT cord-010092-uftc8inx 4859 10 end end NN cord-010092-uftc8inx 4859 11 of of IN cord-010092-uftc8inx 4859 12 their -PRON- PRP$ cord-010092-uftc8inx 4859 13 deferral deferral NN cord-010092-uftc8inx 4859 14 period period NN cord-010092-uftc8inx 4859 15 is be VBZ cord-010092-uftc8inx 4859 16 a a DT cord-010092-uftc8inx 4859 17 simple simple JJ cord-010092-uftc8inx 4859 18 , , , cord-010092-uftc8inx 4859 19 cost cost NN cord-010092-uftc8inx 4859 20 - - HYPH cord-010092-uftc8inx 4859 21 effective effective JJ cord-010092-uftc8inx 4859 22 way way NN cord-010092-uftc8inx 4859 23 to to TO cord-010092-uftc8inx 4859 24 promote promote VB cord-010092-uftc8inx 4859 25 donor donor NN cord-010092-uftc8inx 4859 26 retention retention NN cord-010092-uftc8inx 4859 27 , , , cord-010092-uftc8inx 4859 28 providing provide VBG cord-010092-uftc8inx 4859 29 clear clear JJ cord-010092-uftc8inx 4859 30 information information NN cord-010092-uftc8inx 4859 31 regarding regard VBG cord-010092-uftc8inx 4859 32 the the DT cord-010092-uftc8inx 4859 33 date date NN cord-010092-uftc8inx 4859 34 on on IN cord-010092-uftc8inx 4859 35 which which WDT cord-010092-uftc8inx 4859 36 the the DT cord-010092-uftc8inx 4859 37 donors donor NNS cord-010092-uftc8inx 4859 38 can can MD cord-010092-uftc8inx 4859 39 return return VB cord-010092-uftc8inx 4859 40 to to TO cord-010092-uftc8inx 4859 41 donate donate VB cord-010092-uftc8inx 4859 42 as as RB cord-010092-uftc8inx 4859 43 well well RB cord-010092-uftc8inx 4859 44 as as IN cord-010092-uftc8inx 4859 45 a a DT cord-010092-uftc8inx 4859 46 prompt prompt NN cord-010092-uftc8inx 4859 47 to to TO cord-010092-uftc8inx 4859 48 make make VB cord-010092-uftc8inx 4859 49 an an DT cord-010092-uftc8inx 4859 50 appointment appointment NN cord-010092-uftc8inx 4859 51 Background background NN cord-010092-uftc8inx 4859 52 : : : cord-010092-uftc8inx 4859 53 Our -PRON- PRP$ cord-010092-uftc8inx 4859 54 challenge challenge NN cord-010092-uftc8inx 4859 55 is be VBZ cord-010092-uftc8inx 4859 56 to to TO cord-010092-uftc8inx 4859 57 provide provide VB cord-010092-uftc8inx 4859 58 100 100 CD cord-010092-uftc8inx 4859 59 % % NN cord-010092-uftc8inx 4859 60 voluntary voluntary JJ cord-010092-uftc8inx 4859 61 donation donation NN cord-010092-uftc8inx 4859 62 for for IN cord-010092-uftc8inx 4859 63 safe safe JJ cord-010092-uftc8inx 4859 64 blood blood NN cord-010092-uftc8inx 4859 65 , , , cord-010092-uftc8inx 4859 66 thus thus RB cord-010092-uftc8inx 4859 67 taking take VBG cord-010092-uftc8inx 4859 68 into into IN cord-010092-uftc8inx 4859 69 account account NN cord-010092-uftc8inx 4859 70 the the DT cord-010092-uftc8inx 4859 71 current current JJ cord-010092-uftc8inx 4859 72 history history NN cord-010092-uftc8inx 4859 73 of of IN cord-010092-uftc8inx 4859 74 family family NN cord-010092-uftc8inx 4859 75 donation donation NN cord-010092-uftc8inx 4859 76 , , , cord-010092-uftc8inx 4859 77 promotion promotion NN cord-010092-uftc8inx 4859 78 of of IN cord-010092-uftc8inx 4859 79 blood blood NN cord-010092-uftc8inx 4859 80 donation donation NN cord-010092-uftc8inx 4859 81 , , , cord-010092-uftc8inx 4859 82 level level NN cord-010092-uftc8inx 4859 83 of of IN cord-010092-uftc8inx 4859 84 awareness awareness NN cord-010092-uftc8inx 4859 85 and and CC cord-010092-uftc8inx 4859 86 voluntary voluntary JJ cord-010092-uftc8inx 4859 87 donations donation NNS cord-010092-uftc8inx 4859 88 from from IN cord-010092-uftc8inx 4859 89 various various JJ cord-010092-uftc8inx 4859 90 institutions institution NNS cord-010092-uftc8inx 4859 91 , , , cord-010092-uftc8inx 4859 92 the the DT cord-010092-uftc8inx 4859 93 opinion opinion NN cord-010092-uftc8inx 4859 94 of of IN cord-010092-uftc8inx 4859 95 1000 1000 CD cord-010092-uftc8inx 4859 96 interviewees interviewee NNS cord-010092-uftc8inx 4859 97 will will MD cord-010092-uftc8inx 4859 98 give give VB cord-010092-uftc8inx 4859 99 us -PRON- PRP cord-010092-uftc8inx 4859 100 a a DT cord-010092-uftc8inx 4859 101 clearer clear JJR cord-010092-uftc8inx 4859 102 idea idea NN cord-010092-uftc8inx 4859 103 of of IN cord-010092-uftc8inx 4859 104 what what WP cord-010092-uftc8inx 4859 105 we -PRON- PRP cord-010092-uftc8inx 4859 106 want want VBP cord-010092-uftc8inx 4859 107 to to TO cord-010092-uftc8inx 4859 108 achieve achieve VB cord-010092-uftc8inx 4859 109 and and CC cord-010092-uftc8inx 4859 110 what what WP cord-010092-uftc8inx 4859 111 needs need VBZ cord-010092-uftc8inx 4859 112 to to TO cord-010092-uftc8inx 4859 113 be be VB cord-010092-uftc8inx 4859 114 improved improve VBN cord-010092-uftc8inx 4859 115 in in IN cord-010092-uftc8inx 4859 116 the the DT cord-010092-uftc8inx 4859 117 future future NN cord-010092-uftc8inx 4859 118 . . . cord-010092-uftc8inx 4860 1 Aims aim VBZ cord-010092-uftc8inx 4860 2 : : : cord-010092-uftc8inx 4860 3 1 1 LS cord-010092-uftc8inx 4860 4 . . . cord-010092-uftc8inx 4861 1 Provide provide VB cord-010092-uftc8inx 4861 2 100 100 CD cord-010092-uftc8inx 4861 3 % % NN cord-010092-uftc8inx 4861 4 voluntary voluntary JJ cord-010092-uftc8inx 4861 5 donation donation NN cord-010092-uftc8inx 4861 6 for for IN cord-010092-uftc8inx 4861 7 safe safe JJ cord-010092-uftc8inx 4861 8 blood blood NN cord-010092-uftc8inx 4861 9 . . . cord-010092-uftc8inx 4862 1 2 2 LS cord-010092-uftc8inx 4862 2 . . . cord-010092-uftc8inx 4863 1 Establishing establish VBG cord-010092-uftc8inx 4863 2 a a DT cord-010092-uftc8inx 4863 3 special special JJ cord-010092-uftc8inx 4863 4 department department NN cord-010092-uftc8inx 4863 5 within within IN cord-010092-uftc8inx 4863 6 the the DT cord-010092-uftc8inx 4863 7 National National NNP cord-010092-uftc8inx 4863 8 Blood Blood NNP cord-010092-uftc8inx 4863 9 Transfusion Transfusion NNP cord-010092-uftc8inx 4863 10 Center Center NNP cord-010092-uftc8inx 4863 11 responsible responsible JJ cord-010092-uftc8inx 4863 12 for for IN cord-010092-uftc8inx 4863 13 marketing marketing NN cord-010092-uftc8inx 4863 14 and and CC cord-010092-uftc8inx 4863 15 promotion promotion NN cord-010092-uftc8inx 4863 16 of of IN cord-010092-uftc8inx 4863 17 voluntary voluntary JJ cord-010092-uftc8inx 4863 18 blood blood NN cord-010092-uftc8inx 4863 19 donation donation NN cord-010092-uftc8inx 4863 20 . . . cord-010092-uftc8inx 4864 1 Methods method NNS cord-010092-uftc8inx 4864 2 : : : cord-010092-uftc8inx 4865 1 This this DT cord-010092-uftc8inx 4865 2 study study NN cord-010092-uftc8inx 4865 3 was be VBD cord-010092-uftc8inx 4865 4 conducted conduct VBN cord-010092-uftc8inx 4865 5 as as IN cord-010092-uftc8inx 4865 6 a a DT cord-010092-uftc8inx 4865 7 combination combination NN cord-010092-uftc8inx 4865 8 of of IN cord-010092-uftc8inx 4865 9 qualitative qualitative JJ cord-010092-uftc8inx 4865 10 and and CC cord-010092-uftc8inx 4865 11 quantitative quantitative JJ cord-010092-uftc8inx 4865 12 methods method NNS cord-010092-uftc8inx 4865 13 . . . cord-010092-uftc8inx 4866 1 The the DT cord-010092-uftc8inx 4866 2 study study NN cord-010092-uftc8inx 4866 3 was be VBD cord-010092-uftc8inx 4866 4 a a DT cord-010092-uftc8inx 4866 5 combination combination NN cord-010092-uftc8inx 4866 6 and and CC cord-010092-uftc8inx 4866 7 identification identification NN cord-010092-uftc8inx 4866 8 of of IN cord-010092-uftc8inx 4866 9 existing exist VBG cord-010092-uftc8inx 4866 10 data datum NNS cord-010092-uftc8inx 4866 11 , , , cord-010092-uftc8inx 4866 12 direct direct JJ cord-010092-uftc8inx 4866 13 interviews interview NNS cord-010092-uftc8inx 4866 14 with with IN cord-010092-uftc8inx 4866 15 persons person NNS cord-010092-uftc8inx 4866 16 of of IN cord-010092-uftc8inx 4866 17 different different JJ cord-010092-uftc8inx 4866 18 age age NN cord-010092-uftc8inx 4866 19 groups group NNS cord-010092-uftc8inx 4866 20 , , , cord-010092-uftc8inx 4866 21 preparation preparation NN cord-010092-uftc8inx 4866 22 and and CC cord-010092-uftc8inx 4866 23 dissemination dissemination NN cord-010092-uftc8inx 4866 24 of of IN cord-010092-uftc8inx 4866 25 questionnaires questionnaire NNS cord-010092-uftc8inx 4866 26 and and CC cord-010092-uftc8inx 4866 27 analytical analytical JJ cord-010092-uftc8inx 4866 28 processing processing NN cord-010092-uftc8inx 4866 29 of of IN cord-010092-uftc8inx 4866 30 the the DT cord-010092-uftc8inx 4866 31 collected collect VBN cord-010092-uftc8inx 4866 32 information information NN cord-010092-uftc8inx 4866 33 . . . cord-010092-uftc8inx 4867 1 The the DT cord-010092-uftc8inx 4867 2 study study NN cord-010092-uftc8inx 4867 3 questionnaire questionnaire NN cord-010092-uftc8inx 4867 4 with with IN cord-010092-uftc8inx 4867 5 60 60 CD cord-010092-uftc8inx 4867 6 questions question NNS cord-010092-uftc8inx 4867 7 in in IN cord-010092-uftc8inx 4867 8 total total NN cord-010092-uftc8inx 4867 9 was be VBD cord-010092-uftc8inx 4867 10 divided divide VBN cord-010092-uftc8inx 4867 11 into into IN cord-010092-uftc8inx 4867 12 6 6 CD cord-010092-uftc8inx 4867 13 sections section NNS cord-010092-uftc8inx 4867 14 out out IN cord-010092-uftc8inx 4867 15 of of IN cord-010092-uftc8inx 4867 16 which which WDT cord-010092-uftc8inx 4867 17 14 14 CD cord-010092-uftc8inx 4867 18 questions question NNS cord-010092-uftc8inx 4867 19 on on IN cord-010092-uftc8inx 4867 20 blood blood NN cord-010092-uftc8inx 4867 21 practices practice NNS cord-010092-uftc8inx 4867 22 were be VBD cord-010092-uftc8inx 4867 23 answered answer VBN cord-010092-uftc8inx 4867 24 by by IN cord-010092-uftc8inx 4867 25 all all DT cord-010092-uftc8inx 4867 26 1000 1000 CD cord-010092-uftc8inx 4867 27 interviewees interviewee NNS cord-010092-uftc8inx 4867 28 . . . cord-010092-uftc8inx 4868 1 416 416 CD cord-010092-uftc8inx 4868 2 people people NNS cord-010092-uftc8inx 4868 3 answered answer VBD cord-010092-uftc8inx 4868 4 9 9 CD cord-010092-uftc8inx 4868 5 questions question NNS cord-010092-uftc8inx 4868 6 on on IN cord-010092-uftc8inx 4868 7 the the DT cord-010092-uftc8inx 4868 8 blood blood NN cord-010092-uftc8inx 4868 9 transfusion transfusion NN cord-010092-uftc8inx 4868 10 service service NN cord-010092-uftc8inx 4868 11 . . . cord-010092-uftc8inx 4869 1 5 5 CD cord-010092-uftc8inx 4869 2 questions question NNS cord-010092-uftc8inx 4869 3 on on IN cord-010092-uftc8inx 4869 4 blood blood NN cord-010092-uftc8inx 4869 5 knowledge knowledge NN cord-010092-uftc8inx 4869 6 were be VBD cord-010092-uftc8inx 4869 7 answered answer VBN cord-010092-uftc8inx 4869 8 by by IN cord-010092-uftc8inx 4869 9 270 270 CD cord-010092-uftc8inx 4869 10 people people NNS cord-010092-uftc8inx 4869 11 . . . cord-010092-uftc8inx 4870 1 5 5 CD cord-010092-uftc8inx 4870 2 questions question NNS cord-010092-uftc8inx 4870 3 on on IN cord-010092-uftc8inx 4870 4 the the DT cord-010092-uftc8inx 4870 5 knowledge knowledge NN cord-010092-uftc8inx 4870 6 of of IN cord-010092-uftc8inx 4870 7 the the DT cord-010092-uftc8inx 4870 8 blood blood NN cord-010092-uftc8inx 4870 9 transfusion transfusion NN cord-010092-uftc8inx 4870 10 were be VBD cord-010092-uftc8inx 4870 11 answered answer VBN cord-010092-uftc8inx 4870 12 by by IN cord-010092-uftc8inx 4870 13 220 220 CD cord-010092-uftc8inx 4870 14 people people NNS cord-010092-uftc8inx 4870 15 , , , cord-010092-uftc8inx 4870 16 17 17 CD cord-010092-uftc8inx 4870 17 questions question NNS cord-010092-uftc8inx 4870 18 on on IN cord-010092-uftc8inx 4870 19 blood blood NN cord-010092-uftc8inx 4870 20 donation donation NN cord-010092-uftc8inx 4870 21 were be VBD cord-010092-uftc8inx 4870 22 answered answer VBN cord-010092-uftc8inx 4870 23 by by IN cord-010092-uftc8inx 4870 24 420 420 CD cord-010092-uftc8inx 4870 25 people people NNS cord-010092-uftc8inx 4870 26 and and CC cord-010092-uftc8inx 4870 27 10 10 CD cord-010092-uftc8inx 4870 28 questions question NNS cord-010092-uftc8inx 4870 29 on on IN cord-010092-uftc8inx 4870 30 the the DT cord-010092-uftc8inx 4870 31 communication communication NN cord-010092-uftc8inx 4870 32 channels channel NNS cord-010092-uftc8inx 4870 33 were be VBD cord-010092-uftc8inx 4870 34 answered answer VBN cord-010092-uftc8inx 4870 35 by by IN cord-010092-uftc8inx 4870 36 500 500 CD cord-010092-uftc8inx 4870 37 people people NNS cord-010092-uftc8inx 4870 38 . . . cord-010092-uftc8inx 4871 1 Results result NNS cord-010092-uftc8inx 4871 2 : : : cord-010092-uftc8inx 4872 1 Out out IN cord-010092-uftc8inx 4872 2 of of IN cord-010092-uftc8inx 4872 3 1000 1000 CD cord-010092-uftc8inx 4872 4 interviewees interviewee NNS cord-010092-uftc8inx 4872 5 , , , cord-010092-uftc8inx 4872 6 19 19 CD cord-010092-uftc8inx 4872 7 % % NN cord-010092-uftc8inx 4872 8 have have VBP cord-010092-uftc8inx 4872 9 never never RB cord-010092-uftc8inx 4872 10 donated donate VBN cord-010092-uftc8inx 4872 11 and and CC cord-010092-uftc8inx 4872 12 did do VBD cord-010092-uftc8inx 4872 13 not not RB cord-010092-uftc8inx 4872 14 intend intend VB cord-010092-uftc8inx 4872 15 to to TO cord-010092-uftc8inx 4872 16 donate donate VB cord-010092-uftc8inx 4872 17 , , , cord-010092-uftc8inx 4872 18 due due IN cord-010092-uftc8inx 4872 19 to to IN cord-010092-uftc8inx 4872 20 the the DT cord-010092-uftc8inx 4872 21 fact fact NN cord-010092-uftc8inx 4872 22 that that IN cord-010092-uftc8inx 4872 23 most most JJS cord-010092-uftc8inx 4872 24 of of IN cord-010092-uftc8inx 4872 25 them -PRON- PRP cord-010092-uftc8inx 4872 26 were be VBD cord-010092-uftc8inx 4872 27 afraid afraid JJ cord-010092-uftc8inx 4872 28 of of IN cord-010092-uftc8inx 4872 29 needles needle NNS cord-010092-uftc8inx 4872 30 and and CC cord-010092-uftc8inx 4872 31 infections infection NNS cord-010092-uftc8inx 4872 32 , , , cord-010092-uftc8inx 4872 33 while while IN cord-010092-uftc8inx 4872 34 the the DT cord-010092-uftc8inx 4872 35 smallest small JJS cord-010092-uftc8inx 4872 36 part part NN cord-010092-uftc8inx 4872 37 did do VBD cord-010092-uftc8inx 4872 38 n't not RB cord-010092-uftc8inx 4872 39 donate donate VB cord-010092-uftc8inx 4872 40 blood blood NN cord-010092-uftc8inx 4872 41 because because IN cord-010092-uftc8inx 4872 42 it -PRON- PRP cord-010092-uftc8inx 4872 43 was be VBD cord-010092-uftc8inx 4872 44 not not RB cord-010092-uftc8inx 4872 45 allowed allow VBN cord-010092-uftc8inx 4872 46 by by IN cord-010092-uftc8inx 4872 47 the the DT cord-010092-uftc8inx 4872 48 religion religion NN cord-010092-uftc8inx 4872 49 , , , cord-010092-uftc8inx 4872 50 40 40 CD cord-010092-uftc8inx 4872 51 % % NN cord-010092-uftc8inx 4872 52 did do VBD cord-010092-uftc8inx 4872 53 not not RB cord-010092-uftc8inx 4872 54 donate donate VB cord-010092-uftc8inx 4872 55 , , , cord-010092-uftc8inx 4872 56 but but CC cord-010092-uftc8inx 4872 57 expressed express VBD cord-010092-uftc8inx 4872 58 the the DT cord-010092-uftc8inx 4872 59 readiness readiness NN cord-010092-uftc8inx 4872 60 to to TO cord-010092-uftc8inx 4872 61 donate donate VB cord-010092-uftc8inx 4872 62 in in IN cord-010092-uftc8inx 4872 63 the the DT cord-010092-uftc8inx 4872 64 future future NN cord-010092-uftc8inx 4872 65 , , , cord-010092-uftc8inx 4872 66 10 10 CD cord-010092-uftc8inx 4872 67 % % NN cord-010092-uftc8inx 4872 68 have have VBP cord-010092-uftc8inx 4872 69 donated donate VBN cord-010092-uftc8inx 4872 70 voluntarily voluntarily RB cord-010092-uftc8inx 4872 71 only only RB cord-010092-uftc8inx 4872 72 once once RB cord-010092-uftc8inx 4872 73 , , , cord-010092-uftc8inx 4872 74 24 24 CD cord-010092-uftc8inx 4872 75 % % NN cord-010092-uftc8inx 4872 76 were be VBD cord-010092-uftc8inx 4872 77 family family NN cord-010092-uftc8inx 4872 78 donors donor NNS cord-010092-uftc8inx 4872 79 , , , cord-010092-uftc8inx 4872 80 3 3 CD cord-010092-uftc8inx 4872 81 % % NN cord-010092-uftc8inx 4872 82 regular regular JJ cord-010092-uftc8inx 4872 83 volunteer volunteer NN cord-010092-uftc8inx 4872 84 donors donor NNS cord-010092-uftc8inx 4872 85 , , , cord-010092-uftc8inx 4872 86 and and CC cord-010092-uftc8inx 4872 87 4 4 CD cord-010092-uftc8inx 4872 88 % % NN cord-010092-uftc8inx 4872 89 have have VBP cord-010092-uftc8inx 4872 90 donated donate VBN cord-010092-uftc8inx 4872 91 voluntarily voluntarily RB cord-010092-uftc8inx 4872 92 several several JJ cord-010092-uftc8inx 4872 93 times time NNS cord-010092-uftc8inx 4872 94 and and CC cord-010092-uftc8inx 4872 95 did do VBD cord-010092-uftc8inx 4872 96 not not RB cord-010092-uftc8inx 4872 97 want want VB cord-010092-uftc8inx 4872 98 to to TO cord-010092-uftc8inx 4872 99 donate donate VB cord-010092-uftc8inx 4872 100 anymore anymore RB cord-010092-uftc8inx 4872 101 . . . cord-010092-uftc8inx 4873 1 From from IN cord-010092-uftc8inx 4873 2 those those DT cord-010092-uftc8inx 4873 3 who who WP cord-010092-uftc8inx 4873 4 have have VBP cord-010092-uftc8inx 4873 5 donated donate VBN cord-010092-uftc8inx 4873 6 , , , cord-010092-uftc8inx 4873 7 59 59 CD cord-010092-uftc8inx 4873 8 % % NN cord-010092-uftc8inx 4873 9 have have VBP cord-010092-uftc8inx 4873 10 donated donate VBN cord-010092-uftc8inx 4873 11 for for IN cord-010092-uftc8inx 4873 12 one one CD cord-010092-uftc8inx 4873 13 of of IN cord-010092-uftc8inx 4873 14 their -PRON- PRP$ cord-010092-uftc8inx 4873 15 relatives relative NNS cord-010092-uftc8inx 4873 16 , , , cord-010092-uftc8inx 4873 17 28 28 CD cord-010092-uftc8inx 4873 18 % % NN cord-010092-uftc8inx 4873 19 have have VBP cord-010092-uftc8inx 4873 20 donated donate VBN cord-010092-uftc8inx 4873 21 for for IN cord-010092-uftc8inx 4873 22 thalassemic thalassemic NNP cord-010092-uftc8inx 4873 23 children child NNS cord-010092-uftc8inx 4873 24 , , , cord-010092-uftc8inx 4873 25 10 10 CD cord-010092-uftc8inx 4873 26 % % NN cord-010092-uftc8inx 4873 27 have have VBP cord-010092-uftc8inx 4873 28 donated donate VBN cord-010092-uftc8inx 4873 29 to to TO cord-010092-uftc8inx 4873 30 benefit benefit VB cord-010092-uftc8inx 4873 31 free free JJ cord-010092-uftc8inx 4873 32 check check NN cord-010092-uftc8inx 4873 33 - - HYPH cord-010092-uftc8inx 4873 34 up up NN cord-010092-uftc8inx 4873 35 and and CC cord-010092-uftc8inx 4873 36 3 3 CD cord-010092-uftc8inx 4873 37 % % NN cord-010092-uftc8inx 4873 38 have have VBP cord-010092-uftc8inx 4873 39 donated donate VBN cord-010092-uftc8inx 4873 40 because because IN cord-010092-uftc8inx 4873 41 it -PRON- PRP cord-010092-uftc8inx 4873 42 was be VBD cord-010092-uftc8inx 4873 43 valuable valuable JJ cord-010092-uftc8inx 4873 44 for for IN cord-010092-uftc8inx 4873 45 their -PRON- PRP$ cord-010092-uftc8inx 4873 46 health health NN cord-010092-uftc8inx 4873 47 . . . cord-010092-uftc8inx 4874 1 The the DT cord-010092-uftc8inx 4874 2 question question NN cord-010092-uftc8inx 4874 3 as as IN cord-010092-uftc8inx 4874 4 to to IN cord-010092-uftc8inx 4874 5 whether whether IN cord-010092-uftc8inx 4874 6 they -PRON- PRP cord-010092-uftc8inx 4874 7 would would MD cord-010092-uftc8inx 4874 8 voluntarily voluntarily RB cord-010092-uftc8inx 4874 9 donate donate VB cord-010092-uftc8inx 4874 10 again again RB cord-010092-uftc8inx 4874 11 , , , cord-010092-uftc8inx 4874 12 57 57 CD cord-010092-uftc8inx 4874 13 % % NN cord-010092-uftc8inx 4874 14 have have VBP cord-010092-uftc8inx 4874 15 answered answer VBN cord-010092-uftc8inx 4874 16 yes yes UH cord-010092-uftc8inx 4874 17 , , , cord-010092-uftc8inx 4874 18 22 22 CD cord-010092-uftc8inx 4874 19 % % NN cord-010092-uftc8inx 4875 1 no no UH cord-010092-uftc8inx 4875 2 and and CC cord-010092-uftc8inx 4875 3 21 21 CD cord-010092-uftc8inx 4875 4 % % NN cord-010092-uftc8inx 4875 5 were be VBD cord-010092-uftc8inx 4875 6 still still RB cord-010092-uftc8inx 4875 7 not not RB cord-010092-uftc8inx 4875 8 sure sure JJ cord-010092-uftc8inx 4875 9 . . . cord-010092-uftc8inx 4876 1 This this DT cord-010092-uftc8inx 4876 2 means mean VBZ cord-010092-uftc8inx 4876 3 that that IN cord-010092-uftc8inx 4876 4 donation donation NN cord-010092-uftc8inx 4876 5 of of IN cord-010092-uftc8inx 4876 6 those those DT cord-010092-uftc8inx 4876 7 who who WP cord-010092-uftc8inx 4876 8 have have VBP cord-010092-uftc8inx 4876 9 donated donate VBN cord-010092-uftc8inx 4876 10 once once RB cord-010092-uftc8inx 4876 11 did do VBD cord-010092-uftc8inx 4876 12 not not RB cord-010092-uftc8inx 4876 13 leave leave VB cord-010092-uftc8inx 4876 14 a a DT cord-010092-uftc8inx 4876 15 positive positive JJ cord-010092-uftc8inx 4876 16 impression impression NN cord-010092-uftc8inx 4876 17 , , , cord-010092-uftc8inx 4876 18 did do VBD cord-010092-uftc8inx 4876 19 not not RB cord-010092-uftc8inx 4876 20 increase increase VB cord-010092-uftc8inx 4876 21 the the DT cord-010092-uftc8inx 4876 22 desire desire NN cord-010092-uftc8inx 4876 23 to to TO cord-010092-uftc8inx 4876 24 repeat repeat VB cord-010092-uftc8inx 4876 25 the the DT cord-010092-uftc8inx 4876 26 donation donation NN cord-010092-uftc8inx 4876 27 once once RB cord-010092-uftc8inx 4876 28 again again RB cord-010092-uftc8inx 4876 29 , , , cord-010092-uftc8inx 4876 30 rather rather RB cord-010092-uftc8inx 4876 31 it -PRON- PRP cord-010092-uftc8inx 4876 32 has have VBZ cord-010092-uftc8inx 4876 33 restrained restrain VBN cord-010092-uftc8inx 4876 34 or or CC cord-010092-uftc8inx 4876 35 made make VBN cord-010092-uftc8inx 4876 36 it -PRON- PRP cord-010092-uftc8inx 4876 37 unsafe unsafe JJ cord-010092-uftc8inx 4876 38 for for IN cord-010092-uftc8inx 4876 39 them -PRON- PRP cord-010092-uftc8inx 4876 40 to to TO cord-010092-uftc8inx 4876 41 repeat repeat VB cord-010092-uftc8inx 4876 42 donation donation NN cord-010092-uftc8inx 4876 43 . . . cord-010092-uftc8inx 4877 1 Among among IN cord-010092-uftc8inx 4877 2 the the DT cord-010092-uftc8inx 4877 3 causes cause NNS cord-010092-uftc8inx 4877 4 mentioned mention VBN cord-010092-uftc8inx 4877 5 by by IN cord-010092-uftc8inx 4877 6 the the DT cord-010092-uftc8inx 4877 7 interviewees interviewee NNS cord-010092-uftc8inx 4877 8 were be VBD cord-010092-uftc8inx 4877 9 bad bad JJ cord-010092-uftc8inx 4877 10 conditions condition NNS cord-010092-uftc8inx 4877 11 in in IN cord-010092-uftc8inx 4877 12 the the DT cord-010092-uftc8inx 4877 13 donation donation NN cord-010092-uftc8inx 4877 14 facilities facility NNS cord-010092-uftc8inx 4877 15 , , , cord-010092-uftc8inx 4877 16 staff staff NN cord-010092-uftc8inx 4877 17 behavior behavior NN cord-010092-uftc8inx 4877 18 , , , cord-010092-uftc8inx 4877 19 inadequate inadequate JJ cord-010092-uftc8inx 4877 20 treatment treatment NN cord-010092-uftc8inx 4877 21 , , , cord-010092-uftc8inx 4877 22 they -PRON- PRP cord-010092-uftc8inx 4877 23 did do VBD cord-010092-uftc8inx 4877 24 not not RB cord-010092-uftc8inx 4877 25 feel feel VB cord-010092-uftc8inx 4877 26 good good JJ cord-010092-uftc8inx 4877 27 after after IN cord-010092-uftc8inx 4877 28 donation donation NN cord-010092-uftc8inx 4877 29 and and CC cord-010092-uftc8inx 4877 30 had have VBD cord-010092-uftc8inx 4877 31 hematoma hematoma NN cord-010092-uftc8inx 4877 32 at at IN cord-010092-uftc8inx 4877 33 the the DT cord-010092-uftc8inx 4877 34 venipuncture venipuncture NN cord-010092-uftc8inx 4877 35 . . . cord-010092-uftc8inx 4878 1 Summary Summary NNP cord-010092-uftc8inx 4878 2 / / SYM cord-010092-uftc8inx 4878 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 4878 4 : : : cord-010092-uftc8inx 4879 1 Based base VBN cord-010092-uftc8inx 4879 2 on on IN cord-010092-uftc8inx 4879 3 the the DT cord-010092-uftc8inx 4879 4 results result NNS cord-010092-uftc8inx 4879 5 obtained obtain VBN cord-010092-uftc8inx 4879 6 from from IN cord-010092-uftc8inx 4879 7 the the DT cord-010092-uftc8inx 4879 8 study study NN cord-010092-uftc8inx 4879 9 , , , cord-010092-uftc8inx 4879 10 the the DT cord-010092-uftc8inx 4879 11 National National NNP cord-010092-uftc8inx 4879 12 Blood Blood NNP cord-010092-uftc8inx 4879 13 Transfusion Transfusion NNP cord-010092-uftc8inx 4879 14 Center Center NNP cord-010092-uftc8inx 4879 15 needs need VBZ cord-010092-uftc8inx 4879 16 the the DT cord-010092-uftc8inx 4879 17 establishment establishment NN cord-010092-uftc8inx 4879 18 of of IN cord-010092-uftc8inx 4879 19 a a DT cord-010092-uftc8inx 4879 20 genuine genuine JJ cord-010092-uftc8inx 4879 21 promotion promotion NN cord-010092-uftc8inx 4879 22 department department NN cord-010092-uftc8inx 4879 23 where where WRB cord-010092-uftc8inx 4879 24 there there EX cord-010092-uftc8inx 4879 25 is be VBZ cord-010092-uftc8inx 4879 26 a a DT cord-010092-uftc8inx 4879 27 need need NN cord-010092-uftc8inx 4879 28 for for IN cord-010092-uftc8inx 4879 29 a a DT cord-010092-uftc8inx 4879 30 transfusion transfusion NN cord-010092-uftc8inx 4879 31 doctor doctor NN cord-010092-uftc8inx 4879 32 who who WP cord-010092-uftc8inx 4879 33 should should MD cord-010092-uftc8inx 4879 34 be be VB cord-010092-uftc8inx 4879 35 an an DT cord-010092-uftc8inx 4879 36 active active JJ cord-010092-uftc8inx 4879 37 part part NN cord-010092-uftc8inx 4879 38 of of IN cord-010092-uftc8inx 4879 39 it -PRON- PRP cord-010092-uftc8inx 4879 40 . . . cord-010092-uftc8inx 4880 1 The the DT cord-010092-uftc8inx 4880 2 National National NNP cord-010092-uftc8inx 4880 3 Blood Blood NNP cord-010092-uftc8inx 4880 4 Transfusion Transfusion NNP cord-010092-uftc8inx 4880 5 Center Center NNP cord-010092-uftc8inx 4880 6 should should MD cord-010092-uftc8inx 4880 7 build build VB cord-010092-uftc8inx 4880 8 up up RP cord-010092-uftc8inx 4880 9 and and CC cord-010092-uftc8inx 4880 10 implement implement VB cord-010092-uftc8inx 4880 11 a a DT cord-010092-uftc8inx 4880 12 rigorous rigorous JJ cord-010092-uftc8inx 4880 13 retention retention NN cord-010092-uftc8inx 4880 14 policy policy NN cord-010092-uftc8inx 4880 15 for for IN cord-010092-uftc8inx 4880 16 voluntary voluntary JJ cord-010092-uftc8inx 4880 17 blood blood NN cord-010092-uftc8inx 4880 18 donors donor NNS cord-010092-uftc8inx 4880 19 , , , cord-010092-uftc8inx 4880 20 as as IN cord-010092-uftc8inx 4880 21 the the DT cord-010092-uftc8inx 4880 22 study study NN cord-010092-uftc8inx 4880 23 found find VBD cord-010092-uftc8inx 4880 24 out out RP cord-010092-uftc8inx 4880 25 that that IN cord-010092-uftc8inx 4880 26 around around RB cord-010092-uftc8inx 4880 27 60 60 CD cord-010092-uftc8inx 4880 28 % % NN cord-010092-uftc8inx 4880 29 of of IN cord-010092-uftc8inx 4880 30 donors donor NNS cord-010092-uftc8inx 4880 31 who who WP cord-010092-uftc8inx 4880 32 have have VBP cord-010092-uftc8inx 4880 33 donated donate VBN cord-010092-uftc8inx 4880 34 once once RB cord-010092-uftc8inx 4880 35 would would MD cord-010092-uftc8inx 4880 36 like like VB cord-010092-uftc8inx 4880 37 to to TO cord-010092-uftc8inx 4880 38 donate donate VB cord-010092-uftc8inx 4880 39 again again RB cord-010092-uftc8inx 4880 40 . . . cord-010092-uftc8inx 4881 1 Their -PRON- PRP$ cord-010092-uftc8inx 4881 2 attraction attraction NN cord-010092-uftc8inx 4881 3 through through IN cord-010092-uftc8inx 4881 4 a a DT cord-010092-uftc8inx 4881 5 donor donor NN cord-010092-uftc8inx 4881 6 retention retention NN cord-010092-uftc8inx 4881 7 policy policy NN cord-010092-uftc8inx 4881 8 will will MD cord-010092-uftc8inx 4881 9 surely surely RB cord-010092-uftc8inx 4881 10 lead lead VB cord-010092-uftc8inx 4881 11 to to IN cord-010092-uftc8inx 4881 12 self self NN cord-010092-uftc8inx 4881 13 - - HYPH cord-010092-uftc8inx 4881 14 sufficiency sufficiency NN cord-010092-uftc8inx 4881 15 with with IN cord-010092-uftc8inx 4881 16 safe safe JJ cord-010092-uftc8inx 4881 17 blood blood NN cord-010092-uftc8inx 4881 18 . . . cord-010092-uftc8inx 4882 1 The the DT cord-010092-uftc8inx 4882 2 safe safe JJ cord-010092-uftc8inx 4882 3 blood blood NN cord-010092-uftc8inx 4882 4 is be VBZ cord-010092-uftc8inx 4882 5 a a DT cord-010092-uftc8inx 4882 6 public public JJ cord-010092-uftc8inx 4882 7 good good NN cord-010092-uftc8inx 4882 8 and and CC cord-010092-uftc8inx 4882 9 for for IN cord-010092-uftc8inx 4882 10 this this DT cord-010092-uftc8inx 4882 11 reason reason NN cord-010092-uftc8inx 4882 12 it -PRON- PRP cord-010092-uftc8inx 4882 13 is be VBZ cord-010092-uftc8inx 4882 14 the the DT cord-010092-uftc8inx 4882 15 duty duty NN cord-010092-uftc8inx 4882 16 of of IN cord-010092-uftc8inx 4882 17 all all DT cord-010092-uftc8inx 4882 18 state state NN cord-010092-uftc8inx 4882 19 instances instance NNS cord-010092-uftc8inx 4882 20 , , , cord-010092-uftc8inx 4882 21 the the DT cord-010092-uftc8inx 4882 22 media medium NNS cord-010092-uftc8inx 4882 23 and and CC cord-010092-uftc8inx 4882 24 non non JJ cord-010092-uftc8inx 4882 25 - - JJ cord-010092-uftc8inx 4882 26 governmental governmental JJ cord-010092-uftc8inx 4882 27 organizations organization NNS cord-010092-uftc8inx 4882 28 to to TO cord-010092-uftc8inx 4882 29 give give VB cord-010092-uftc8inx 4882 30 their -PRON- PRP$ cord-010092-uftc8inx 4882 31 support support NN cord-010092-uftc8inx 4882 32 in in IN cord-010092-uftc8inx 4882 33 the the DT cord-010092-uftc8inx 4882 34 promotion promotion NN cord-010092-uftc8inx 4882 35 of of IN cord-010092-uftc8inx 4882 36 voluntary voluntary JJ cord-010092-uftc8inx 4882 37 blood blood NN cord-010092-uftc8inx 4882 38 donation donation NN cord-010092-uftc8inx 4882 39 . . . cord-010092-uftc8inx 4883 1 Background background NN cord-010092-uftc8inx 4883 2 : : : cord-010092-uftc8inx 4884 1 Smoking smoking NN cord-010092-uftc8inx 4884 2 , , , cord-010092-uftc8inx 4884 3 unhealthy unhealthy JJ cord-010092-uftc8inx 4884 4 diet diet NN cord-010092-uftc8inx 4884 5 , , , cord-010092-uftc8inx 4884 6 sedentary sedentary JJ cord-010092-uftc8inx 4884 7 behavior behavior NN cord-010092-uftc8inx 4884 8 and and CC cord-010092-uftc8inx 4884 9 inability inability NN cord-010092-uftc8inx 4884 10 to to TO cord-010092-uftc8inx 4884 11 maintain maintain VB cord-010092-uftc8inx 4884 12 adequate adequate JJ cord-010092-uftc8inx 4884 13 exercise exercise NN cord-010092-uftc8inx 4884 14 have have VBP cord-010092-uftc8inx 4884 15 significant significant JJ cord-010092-uftc8inx 4884 16 consequences consequence NNS cord-010092-uftc8inx 4884 17 for for IN cord-010092-uftc8inx 4884 18 several several JJ cord-010092-uftc8inx 4884 19 chronic chronic JJ cord-010092-uftc8inx 4884 20 disorders disorder NNS cord-010092-uftc8inx 4884 21 , , , cord-010092-uftc8inx 4884 22 including include VBG cord-010092-uftc8inx 4884 23 obesity obesity NN cord-010092-uftc8inx 4884 24 . . . cord-010092-uftc8inx 4885 1 A a DT cord-010092-uftc8inx 4885 2 balanced balanced JJ cord-010092-uftc8inx 4885 3 and and CC cord-010092-uftc8inx 4885 4 equilibrate equilibrate VB cord-010092-uftc8inx 4885 5 nutrition nutrition NN cord-010092-uftc8inx 4885 6 may may MD cord-010092-uftc8inx 4885 7 prevent prevent VB cord-010092-uftc8inx 4885 8 the the DT cord-010092-uftc8inx 4885 9 negative negative JJ cord-010092-uftc8inx 4885 10 consequences consequence NNS cord-010092-uftc8inx 4885 11 associated associate VBN cord-010092-uftc8inx 4885 12 to to IN cord-010092-uftc8inx 4885 13 the the DT cord-010092-uftc8inx 4885 14 status status NN cord-010092-uftc8inx 4885 15 of of IN cord-010092-uftc8inx 4885 16 obesity obesity NN cord-010092-uftc8inx 4885 17 . . . cord-010092-uftc8inx 4886 1 In in IN cord-010092-uftc8inx 4886 2 Italy Italy NNP cord-010092-uftc8inx 4886 3 , , , cord-010092-uftc8inx 4886 4 overweight overweight NN cord-010092-uftc8inx 4886 5 and and CC cord-010092-uftc8inx 4886 6 obesity obesity NN cord-010092-uftc8inx 4886 7 is be VBZ cord-010092-uftc8inx 4886 8 increasing increase VBG cord-010092-uftc8inx 4886 9 with with IN cord-010092-uftc8inx 4886 10 3 3 CD cord-010092-uftc8inx 4886 11 adults adult NNS cord-010092-uftc8inx 4886 12 of of IN cord-010092-uftc8inx 4886 13 10 10 CD cord-010092-uftc8inx 4886 14 overweight overweight NN cord-010092-uftc8inx 4886 15 and and CC cord-010092-uftc8inx 4886 16 1 1 CD cord-010092-uftc8inx 4886 17 of of IN cord-010092-uftc8inx 4886 18 10 10 CD cord-010092-uftc8inx 4886 19 obese obese JJ cord-010092-uftc8inx 4886 20 in in IN cord-010092-uftc8inx 4886 21 2017 2017 CD cord-010092-uftc8inx 4886 22 with with IN cord-010092-uftc8inx 4886 23 a a DT cord-010092-uftc8inx 4886 24 higher high JJR cord-010092-uftc8inx 4886 25 frequency frequency NN cord-010092-uftc8inx 4886 26 in in IN cord-010092-uftc8inx 4886 27 the the DT cord-010092-uftc8inx 4886 28 South South NNP cord-010092-uftc8inx 4886 29 . . . cord-010092-uftc8inx 4887 1 Blood blood NN cord-010092-uftc8inx 4887 2 centers center NNS cord-010092-uftc8inx 4887 3 can can MD cord-010092-uftc8inx 4887 4 play play VB cord-010092-uftc8inx 4887 5 a a DT cord-010092-uftc8inx 4887 6 public public JJ cord-010092-uftc8inx 4887 7 health health NN cord-010092-uftc8inx 4887 8 role role NN cord-010092-uftc8inx 4887 9 in in IN cord-010092-uftc8inx 4887 10 obesity obesity NN cord-010092-uftc8inx 4887 11 surveillance surveillance NN cord-010092-uftc8inx 4887 12 and and CC cord-010092-uftc8inx 4887 13 interventions intervention NNS cord-010092-uftc8inx 4887 14 . . . cord-010092-uftc8inx 4888 1 Aims aim VBZ cord-010092-uftc8inx 4888 2 : : : cord-010092-uftc8inx 4889 1 Since since IN cord-010092-uftc8inx 4889 2 the the DT cord-010092-uftc8inx 4889 3 quality quality NN cord-010092-uftc8inx 4889 4 of of IN cord-010092-uftc8inx 4889 5 life life NN cord-010092-uftc8inx 4889 6 , , , cord-010092-uftc8inx 4889 7 self self NN cord-010092-uftc8inx 4889 8 - - HYPH cord-010092-uftc8inx 4889 9 reported report VBN cord-010092-uftc8inx 4889 10 by by IN cord-010092-uftc8inx 4889 11 the the DT cord-010092-uftc8inx 4889 12 patient patient NN cord-010092-uftc8inx 4889 13 , , , cord-010092-uftc8inx 4889 14 related relate VBN cord-010092-uftc8inx 4889 15 to to IN cord-010092-uftc8inx 4889 16 health health NN cord-010092-uftc8inx 4889 17 and and CC cord-010092-uftc8inx 4889 18 adequate adequate JJ cord-010092-uftc8inx 4889 19 quali quali JJ cord-010092-uftc8inx 4889 20 - - HYPH cord-010092-uftc8inx 4889 21 quantitative quantitative JJ cord-010092-uftc8inx 4889 22 nutrition nutrition NN cord-010092-uftc8inx 4889 23 , , , cord-010092-uftc8inx 4889 24 are be VBP cord-010092-uftc8inx 4889 25 becoming become VBG cord-010092-uftc8inx 4889 26 necessary necessary JJ cord-010092-uftc8inx 4889 27 and and CC cord-010092-uftc8inx 4889 28 relevant relevant JJ cord-010092-uftc8inx 4889 29 in in IN cord-010092-uftc8inx 4889 30 the the DT cord-010092-uftc8inx 4889 31 field field NN cord-010092-uftc8inx 4889 32 of of IN cord-010092-uftc8inx 4889 33 nutrition nutrition NN cord-010092-uftc8inx 4889 34 , , , cord-010092-uftc8inx 4889 35 we -PRON- PRP cord-010092-uftc8inx 4889 36 conducted conduct VBD cord-010092-uftc8inx 4889 37 a a DT cord-010092-uftc8inx 4889 38 demographic demographic JJ cord-010092-uftc8inx 4889 39 study study NN cord-010092-uftc8inx 4889 40 to to TO cord-010092-uftc8inx 4889 41 evaluate evaluate VB cord-010092-uftc8inx 4889 42 the the DT cord-010092-uftc8inx 4889 43 health health NN cord-010092-uftc8inx 4889 44 status status NN cord-010092-uftc8inx 4889 45 of of IN cord-010092-uftc8inx 4889 46 the the DT cord-010092-uftc8inx 4889 47 blood blood NN cord-010092-uftc8inx 4889 48 donors donor NNS cord-010092-uftc8inx 4889 49 by by IN cord-010092-uftc8inx 4889 50 monitoring monitor VBG cord-010092-uftc8inx 4889 51 the the DT cord-010092-uftc8inx 4889 52 nutritional nutritional JJ cord-010092-uftc8inx 4889 53 habits habit NNS cord-010092-uftc8inx 4889 54 and and CC cord-010092-uftc8inx 4889 55 lifestyle lifestyle NN cord-010092-uftc8inx 4889 56 . . . cord-010092-uftc8inx 4890 1 Methods method NNS cord-010092-uftc8inx 4890 2 : : : cord-010092-uftc8inx 4891 1 A a DT cord-010092-uftc8inx 4891 2 descriptive descriptive JJ cord-010092-uftc8inx 4891 3 cross cross JJ cord-010092-uftc8inx 4891 4 - - JJ cord-010092-uftc8inx 4891 5 sectional sectional JJ cord-010092-uftc8inx 4891 6 face face NN cord-010092-uftc8inx 4891 7 - - HYPH cord-010092-uftc8inx 4891 8 to to IN cord-010092-uftc8inx 4891 9 - - HYPH cord-010092-uftc8inx 4891 10 face face NN cord-010092-uftc8inx 4891 11 questionnaire questionnaire NN cord-010092-uftc8inx 4891 12 was be VBD cord-010092-uftc8inx 4891 13 developed develop VBN cord-010092-uftc8inx 4891 14 . . . cord-010092-uftc8inx 4892 1 It -PRON- PRP cord-010092-uftc8inx 4892 2 included include VBD cord-010092-uftc8inx 4892 3 a a DT cord-010092-uftc8inx 4892 4 41 41 CD cord-010092-uftc8inx 4892 5 item item NN cord-010092-uftc8inx 4892 6 dietary dietary JJ cord-010092-uftc8inx 4892 7 assessment assessment NN cord-010092-uftc8inx 4892 8 , , , cord-010092-uftc8inx 4892 9 reporting report VBG cord-010092-uftc8inx 4892 10 semi semi JJ cord-010092-uftc8inx 4892 11 - - JJ cord-010092-uftc8inx 4892 12 quantitative quantitative JJ cord-010092-uftc8inx 4892 13 food food NN cord-010092-uftc8inx 4892 14 frequency frequency NN cord-010092-uftc8inx 4892 15 , , , cord-010092-uftc8inx 4892 16 dietary dietary JJ cord-010092-uftc8inx 4892 17 behavior behavior NN cord-010092-uftc8inx 4892 18 and and CC cord-010092-uftc8inx 4892 19 questions question NNS cord-010092-uftc8inx 4892 20 on on IN cord-010092-uftc8inx 4892 21 self self NN cord-010092-uftc8inx 4892 22 - - HYPH cord-010092-uftc8inx 4892 23 rated rate VBN cord-010092-uftc8inx 4892 24 health health NN cord-010092-uftc8inx 4892 25 status status NN cord-010092-uftc8inx 4892 26 . . . cord-010092-uftc8inx 4893 1 Normal normal JJ cord-010092-uftc8inx 4893 2 weight weight NN cord-010092-uftc8inx 4893 3 was be VBD cord-010092-uftc8inx 4893 4 established establish VBN cord-010092-uftc8inx 4893 5 with with IN cord-010092-uftc8inx 4893 6 BMI BMI NNP cord-010092-uftc8inx 4893 7 < < XX cord-010092-uftc8inx 4893 8 25 25 CD cord-010092-uftc8inx 4893 9 kg kg NNS cord-010092-uftc8inx 4893 10 / / SYM cord-010092-uftc8inx 4893 11 m m NN cord-010092-uftc8inx 4893 12 2 2 CD cord-010092-uftc8inx 4893 13 , , , cord-010092-uftc8inx 4893 14 overweight overweight JJ cord-010092-uftc8inx 4893 15 with with IN cord-010092-uftc8inx 4893 16 a a DT cord-010092-uftc8inx 4893 17 BMI BMI NNP cord-010092-uftc8inx 4893 18 ≥ ≥ NNP cord-010092-uftc8inx 4893 19 25 25 CD cord-010092-uftc8inx 4893 20 and and CC cord-010092-uftc8inx 4893 21 < < NNP cord-010092-uftc8inx 4893 22 30 30 CD cord-010092-uftc8inx 4893 23 kg kg NN cord-010092-uftc8inx 4893 24 / / SYM cord-010092-uftc8inx 4893 25 m m NN cord-010092-uftc8inx 4893 26 2 2 CD cord-010092-uftc8inx 4893 27 , , , cord-010092-uftc8inx 4893 28 and and CC cord-010092-uftc8inx 4893 29 obesity obesity NN cord-010092-uftc8inx 4893 30 with with IN cord-010092-uftc8inx 4893 31 BMI BMI NNP cord-010092-uftc8inx 4893 32 ≥ ≥ NNP cord-010092-uftc8inx 4893 33 30 30 CD cord-010092-uftc8inx 4893 34 kg kg NN cord-010092-uftc8inx 4893 35 / / SYM cord-010092-uftc8inx 4893 36 m m NN cord-010092-uftc8inx 4893 37 2 2 CD cord-010092-uftc8inx 4893 38 . . . cord-010092-uftc8inx 4894 1 Obesity obesity NN cord-010092-uftc8inx 4894 2 prevalence prevalence NN cord-010092-uftc8inx 4894 3 was be VBD cord-010092-uftc8inx 4894 4 standardized standardize VBN cord-010092-uftc8inx 4894 5 by by IN cord-010092-uftc8inx 4894 6 sex sex NN cord-010092-uftc8inx 4894 7 . . . cord-010092-uftc8inx 4895 1 Donors donor NNS cord-010092-uftc8inx 4895 2 were be VBD cord-010092-uftc8inx 4895 3 repeat repeat VB cord-010092-uftc8inx 4895 4 blood blood NN cord-010092-uftc8inx 4895 5 donors donor NNS cord-010092-uftc8inx 4895 6 , , , cord-010092-uftc8inx 4895 7 who who WP cord-010092-uftc8inx 4895 8 had have VBD cord-010092-uftc8inx 4895 9 made make VBN cord-010092-uftc8inx 4895 10 at at IN cord-010092-uftc8inx 4895 11 least least JJS cord-010092-uftc8inx 4895 12 3 3 CD cord-010092-uftc8inx 4895 13 donations donation NNS cord-010092-uftc8inx 4895 14 in in IN cord-010092-uftc8inx 4895 15 the the DT cord-010092-uftc8inx 4895 16 last last JJ cord-010092-uftc8inx 4895 17 2 2 CD cord-010092-uftc8inx 4895 18 years year NNS cord-010092-uftc8inx 4895 19 , , , cord-010092-uftc8inx 4895 20 and and CC cord-010092-uftc8inx 4895 21 were be VBD cord-010092-uftc8inx 4895 22 eligible eligible JJ cord-010092-uftc8inx 4895 23 to to TO cord-010092-uftc8inx 4895 24 donate donate VB cord-010092-uftc8inx 4895 25 . . . cord-010092-uftc8inx 4896 1 Results result NNS cord-010092-uftc8inx 4896 2 : : : cord-010092-uftc8inx 4897 1 Of of IN cord-010092-uftc8inx 4897 2 the the DT cord-010092-uftc8inx 4897 3 2468 2468 CD cord-010092-uftc8inx 4897 4 blood blood NN cord-010092-uftc8inx 4897 5 donors donor NNS cord-010092-uftc8inx 4897 6 enrolled enrol VBN cord-010092-uftc8inx 4897 7 between between IN cord-010092-uftc8inx 4897 8 July July NNP cord-010092-uftc8inx 4897 9 2017 2017 CD cord-010092-uftc8inx 4897 10 and and CC cord-010092-uftc8inx 4897 11 January January NNP cord-010092-uftc8inx 4897 12 2018 2018 CD cord-010092-uftc8inx 4897 13 , , , cord-010092-uftc8inx 4897 14 1390 1390 CD cord-010092-uftc8inx 4897 15 were be VBD cord-010092-uftc8inx 4897 16 regular regular JJ cord-010092-uftc8inx 4897 17 repeat repeat NN cord-010092-uftc8inx 4897 18 donors donor NNS cord-010092-uftc8inx 4897 19 , , , cord-010092-uftc8inx 4897 20 1102 1102 CD cord-010092-uftc8inx 4897 21 did do VBD cord-010092-uftc8inx 4897 22 not not RB cord-010092-uftc8inx 4897 23 wish wish VB cord-010092-uftc8inx 4897 24 or or CC cord-010092-uftc8inx 4897 25 chose choose VBD cord-010092-uftc8inx 4897 26 not not RB cord-010092-uftc8inx 4897 27 to to TO cord-010092-uftc8inx 4897 28 respond respond VB cord-010092-uftc8inx 4897 29 at at IN cord-010092-uftc8inx 4897 30 survey survey NN cord-010092-uftc8inx 4897 31 for for IN cord-010092-uftc8inx 4897 32 several several JJ cord-010092-uftc8inx 4897 33 reasons reason NNS cord-010092-uftc8inx 4897 34 ( ( -LRB- cord-010092-uftc8inx 4897 35 i.e. i.e. FW cord-010092-uftc8inx 4897 36 lack lack NN cord-010092-uftc8inx 4897 37 of of IN cord-010092-uftc8inx 4897 38 time time NN cord-010092-uftc8inx 4897 39 or or CC cord-010092-uftc8inx 4897 40 privacy privacy NN cord-010092-uftc8inx 4897 41 ) ) -RRB- cord-010092-uftc8inx 4897 42 and and CC cord-010092-uftc8inx 4897 43 288 288 CD cord-010092-uftc8inx 4897 44 accepted accept VBD cord-010092-uftc8inx 4897 45 , , , cord-010092-uftc8inx 4897 46 of of IN cord-010092-uftc8inx 4897 47 which which WDT cord-010092-uftc8inx 4897 48 83 83 CD cord-010092-uftc8inx 4897 49 were be VBD cord-010092-uftc8inx 4897 50 deferred defer VBN cord-010092-uftc8inx 4897 51 from from IN cord-010092-uftc8inx 4897 52 blood blood NN cord-010092-uftc8inx 4897 53 donation donation NN cord-010092-uftc8inx 4897 54 and and CC cord-010092-uftc8inx 4897 55 were be VBD cord-010092-uftc8inx 4897 56 excluded exclude VBN cord-010092-uftc8inx 4897 57 from from IN cord-010092-uftc8inx 4897 58 the the DT cord-010092-uftc8inx 4897 59 analysis analysis NN cord-010092-uftc8inx 4897 60 . . . cord-010092-uftc8inx 4898 1 Among among IN cord-010092-uftc8inx 4898 2 the the DT cord-010092-uftc8inx 4898 3 205 205 CD cord-010092-uftc8inx 4898 4 included include VBD cord-010092-uftc8inx 4898 5 participants participant NNS cord-010092-uftc8inx 4898 6 68.3 68.3 CD cord-010092-uftc8inx 4898 7 % % NN cord-010092-uftc8inx 4898 8 ( ( -LRB- cord-010092-uftc8inx 4898 9 n n NN cord-010092-uftc8inx 4898 10 = = SYM cord-010092-uftc8inx 4898 11 140 140 CD cord-010092-uftc8inx 4898 12 ) ) -RRB- cord-010092-uftc8inx 4898 13 were be VBD cord-010092-uftc8inx 4898 14 male male JJ cord-010092-uftc8inx 4898 15 , , , cord-010092-uftc8inx 4898 16 age age NN cord-010092-uftc8inx 4898 17 ranged range VBD cord-010092-uftc8inx 4898 18 from from IN cord-010092-uftc8inx 4898 19 19 19 CD cord-010092-uftc8inx 4898 20 - - SYM cord-010092-uftc8inx 4898 21 61 61 CD cord-010092-uftc8inx 4898 22 years year NNS cord-010092-uftc8inx 4898 23 with with IN cord-010092-uftc8inx 4898 24 a a DT cord-010092-uftc8inx 4898 25 mean mean JJ cord-010092-uftc8inx 4898 26 age age NN cord-010092-uftc8inx 4898 27 of of IN cord-010092-uftc8inx 4898 28 39.8 39.8 CD cord-010092-uftc8inx 4898 29 AE AE NNP cord-010092-uftc8inx 4898 30 11.1 11.1 CD cord-010092-uftc8inx 4898 31 SD sd NN cord-010092-uftc8inx 4898 32 and and CC cord-010092-uftc8inx 4898 33 31.7 31.7 CD cord-010092-uftc8inx 4898 34 % % NN cord-010092-uftc8inx 4898 35 ( ( -LRB- cord-010092-uftc8inx 4898 36 n n NN cord-010092-uftc8inx 4898 37 = = SYM cord-010092-uftc8inx 4898 38 65 65 CD cord-010092-uftc8inx 4898 39 ) ) -RRB- cord-010092-uftc8inx 4898 40 were be VBD cord-010092-uftc8inx 4898 41 female female JJ cord-010092-uftc8inx 4898 42 age age NN cord-010092-uftc8inx 4898 43 ranged range VBD cord-010092-uftc8inx 4898 44 from from IN cord-010092-uftc8inx 4898 45 20 20 CD cord-010092-uftc8inx 4898 46 - - SYM cord-010092-uftc8inx 4898 47 62 62 CD cord-010092-uftc8inx 4898 48 years year NNS cord-010092-uftc8inx 4898 49 with with IN cord-010092-uftc8inx 4898 50 a a DT cord-010092-uftc8inx 4898 51 mean mean JJ cord-010092-uftc8inx 4898 52 age age NN cord-010092-uftc8inx 4898 53 of of IN cord-010092-uftc8inx 4898 54 37.7 37.7 CD cord-010092-uftc8inx 4898 55 AE AE NNP cord-010092-uftc8inx 4898 56 11.0 11.0 CD cord-010092-uftc8inx 4898 57 SD sd NN cord-010092-uftc8inx 4898 58 . . . cord-010092-uftc8inx 4899 1 Data datum NNS cord-010092-uftc8inx 4899 2 showed show VBD cord-010092-uftc8inx 4899 3 that that IN cord-010092-uftc8inx 4899 4 donors donor NNS cord-010092-uftc8inx 4899 5 followed follow VBD cord-010092-uftc8inx 4899 6 mainly mainly RB cord-010092-uftc8inx 4899 7 a a DT cord-010092-uftc8inx 4899 8 Mediterranean Mediterranean NNP cord-010092-uftc8inx 4899 9 diet diet NN cord-010092-uftc8inx 4899 10 and and CC cord-010092-uftc8inx 4899 11 had have VBD cord-010092-uftc8inx 4899 12 more more JJR cord-010092-uftc8inx 4899 13 awareness awareness NN cord-010092-uftc8inx 4899 14 to to IN cord-010092-uftc8inx 4899 15 lifestyle lifestyle NN cord-010092-uftc8inx 4899 16 , , , cord-010092-uftc8inx 4899 17 women woman NNS cord-010092-uftc8inx 4899 18 more more JJR cord-010092-uftc8inx 4899 19 than than IN cord-010092-uftc8inx 4899 20 men man NNS cord-010092-uftc8inx 4899 21 , , , cord-010092-uftc8inx 4899 22 in in IN cord-010092-uftc8inx 4899 23 comparison comparison NN cord-010092-uftc8inx 4899 24 with with IN cord-010092-uftc8inx 4899 25 general general JJ cord-010092-uftc8inx 4899 26 population population NN cord-010092-uftc8inx 4899 27 . . . cord-010092-uftc8inx 4900 1 The the DT cord-010092-uftc8inx 4900 2 prevalence prevalence NN cord-010092-uftc8inx 4900 3 of of IN cord-010092-uftc8inx 4900 4 overweight overweight NN cord-010092-uftc8inx 4900 5 was be VBD cord-010092-uftc8inx 4900 6 found find VBN cord-010092-uftc8inx 4900 7 50.7 50.7 CD cord-010092-uftc8inx 4900 8 % % NN cord-010092-uftc8inx 4900 9 in in IN cord-010092-uftc8inx 4900 10 men man NNS cord-010092-uftc8inx 4900 11 and and CC cord-010092-uftc8inx 4900 12 16.9 16.9 CD cord-010092-uftc8inx 4900 13 % % NN cord-010092-uftc8inx 4900 14 in in IN cord-010092-uftc8inx 4900 15 women woman NNS cord-010092-uftc8inx 4900 16 . . . cord-010092-uftc8inx 4901 1 Our -PRON- PRP$ cord-010092-uftc8inx 4901 2 survey survey NN cord-010092-uftc8inx 4901 3 showed show VBD cord-010092-uftc8inx 4901 4 that that IN cord-010092-uftc8inx 4901 5 84.4 84.4 CD cord-010092-uftc8inx 4901 6 % % NN cord-010092-uftc8inx 4901 7 of of IN cord-010092-uftc8inx 4901 8 the the DT cord-010092-uftc8inx 4901 9 participants participant NNS cord-010092-uftc8inx 4901 10 evaluated evaluate VBD cord-010092-uftc8inx 4901 11 their -PRON- PRP$ cord-010092-uftc8inx 4901 12 health health NN cord-010092-uftc8inx 4901 13 as as IN cord-010092-uftc8inx 4901 14 " " `` cord-010092-uftc8inx 4901 15 good good JJ cord-010092-uftc8inx 4901 16 " " '' cord-010092-uftc8inx 4901 17 , , , cord-010092-uftc8inx 4901 18 without without IN cord-010092-uftc8inx 4901 19 gender gender NN cord-010092-uftc8inx 4901 20 difference difference NN cord-010092-uftc8inx 4901 21 ( ( -LRB- cord-010092-uftc8inx 4901 22 men man NNS cord-010092-uftc8inx 4901 23 , , , cord-010092-uftc8inx 4901 24 86.4 86.4 CD cord-010092-uftc8inx 4901 25 % % NN cord-010092-uftc8inx 4901 26 vs vs IN cord-010092-uftc8inx 4901 27 women woman NNS cord-010092-uftc8inx 4901 28 , , , cord-010092-uftc8inx 4901 29 80.0 80.0 CD cord-010092-uftc8inx 4901 30 % % NN cord-010092-uftc8inx 4901 31 ) ) -RRB- cord-010092-uftc8inx 4901 32 . . . cord-010092-uftc8inx 4902 1 Besides besides RB cord-010092-uftc8inx 4902 2 , , , cord-010092-uftc8inx 4902 3 14.6 14.6 CD cord-010092-uftc8inx 4902 4 % % NN cord-010092-uftc8inx 4902 5 reported report VBD cord-010092-uftc8inx 4902 6 their -PRON- PRP$ cord-010092-uftc8inx 4902 7 health health NN cord-010092-uftc8inx 4902 8 as as IN cord-010092-uftc8inx 4902 9 " " `` cord-010092-uftc8inx 4902 10 very very RB cord-010092-uftc8inx 4902 11 good good JJ cord-010092-uftc8inx 4902 12 " " '' cord-010092-uftc8inx 4902 13 . . . cord-010092-uftc8inx 4903 1 Summary Summary NNP cord-010092-uftc8inx 4903 2 / / SYM cord-010092-uftc8inx 4903 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 4903 4 : : : cord-010092-uftc8inx 4904 1 Overweight overweight JJ cord-010092-uftc8inx 4904 2 and and CC cord-010092-uftc8inx 4904 3 obesity obesity NN cord-010092-uftc8inx 4904 4 are be VBP cord-010092-uftc8inx 4904 5 common common JJ cord-010092-uftc8inx 4904 6 among among IN cord-010092-uftc8inx 4904 7 regular regular JJ cord-010092-uftc8inx 4904 8 blood blood NN cord-010092-uftc8inx 4904 9 donors donor NNS cord-010092-uftc8inx 4904 10 and and CC cord-010092-uftc8inx 4904 11 it -PRON- PRP cord-010092-uftc8inx 4904 12 is be VBZ cord-010092-uftc8inx 4904 13 more more RBR cord-010092-uftc8inx 4904 14 frequent frequent JJ cord-010092-uftc8inx 4904 15 in in IN cord-010092-uftc8inx 4904 16 men man NNS cord-010092-uftc8inx 4904 17 than than IN cord-010092-uftc8inx 4904 18 women woman NNS cord-010092-uftc8inx 4904 19 . . . cord-010092-uftc8inx 4905 1 Our -PRON- PRP$ cord-010092-uftc8inx 4905 2 preliminary preliminary JJ cord-010092-uftc8inx 4905 3 data datum NNS cord-010092-uftc8inx 4905 4 showed show VBD cord-010092-uftc8inx 4905 5 that that IN cord-010092-uftc8inx 4905 6 women woman NNS cord-010092-uftc8inx 4905 7 have have VBP cord-010092-uftc8inx 4905 8 a a DT cord-010092-uftc8inx 4905 9 better well JJR cord-010092-uftc8inx 4905 10 knowledge knowledge NN cord-010092-uftc8inx 4905 11 of of IN cord-010092-uftc8inx 4905 12 the the DT cord-010092-uftc8inx 4905 13 nutritional nutritional JJ cord-010092-uftc8inx 4905 14 properties property NNS cord-010092-uftc8inx 4905 15 of of IN cord-010092-uftc8inx 4905 16 food food NN cord-010092-uftc8inx 4905 17 and and CC cord-010092-uftc8inx 4905 18 consequently consequently RB cord-010092-uftc8inx 4905 19 adopt adopt VB cord-010092-uftc8inx 4905 20 a a DT cord-010092-uftc8inx 4905 21 more more RBR cord-010092-uftc8inx 4905 22 balanced balanced JJ cord-010092-uftc8inx 4905 23 and and CC cord-010092-uftc8inx 4905 24 proper proper JJ cord-010092-uftc8inx 4905 25 diet diet NN cord-010092-uftc8inx 4905 26 . . . cord-010092-uftc8inx 4906 1 Furthermore furthermore RB cord-010092-uftc8inx 4906 2 , , , cord-010092-uftc8inx 4906 3 it -PRON- PRP cord-010092-uftc8inx 4906 4 is be VBZ cord-010092-uftc8inx 4906 5 clear clear JJ cord-010092-uftc8inx 4906 6 that that IN cord-010092-uftc8inx 4906 7 they -PRON- PRP cord-010092-uftc8inx 4906 8 are be VBP cord-010092-uftc8inx 4906 9 aware aware JJ cord-010092-uftc8inx 4906 10 about about IN cord-010092-uftc8inx 4906 11 the the DT cord-010092-uftc8inx 4906 12 relationship relationship NN cord-010092-uftc8inx 4906 13 between between IN cord-010092-uftc8inx 4906 14 lifestyle lifestyle NN cord-010092-uftc8inx 4906 15 and and CC cord-010092-uftc8inx 4906 16 health health NN cord-010092-uftc8inx 4906 17 putting put VBG cord-010092-uftc8inx 4906 18 into into IN cord-010092-uftc8inx 4906 19 practice practice NN cord-010092-uftc8inx 4906 20 their -PRON- PRP$ cord-010092-uftc8inx 4906 21 information information NN cord-010092-uftc8inx 4906 22 . . . cord-010092-uftc8inx 4907 1 Unfortunately unfortunately RB cord-010092-uftc8inx 4907 2 , , , cord-010092-uftc8inx 4907 3 the the DT cord-010092-uftc8inx 4907 4 survey survey NN cord-010092-uftc8inx 4907 5 structure structure NN cord-010092-uftc8inx 4907 6 , , , cord-010092-uftc8inx 4907 7 of of IN cord-010092-uftc8inx 4907 8 observational observational JJ cord-010092-uftc8inx 4907 9 nature nature NN cord-010092-uftc8inx 4907 10 , , , cord-010092-uftc8inx 4907 11 does do VBZ cord-010092-uftc8inx 4907 12 not not RB cord-010092-uftc8inx 4907 13 make make VB cord-010092-uftc8inx 4907 14 it -PRON- PRP cord-010092-uftc8inx 4907 15 possible possible JJ cord-010092-uftc8inx 4907 16 to to TO cord-010092-uftc8inx 4907 17 establish establish VB cord-010092-uftc8inx 4907 18 whether whether IN cord-010092-uftc8inx 4907 19 women woman NNS cord-010092-uftc8inx 4907 20 are be VBP cord-010092-uftc8inx 4907 21 more more RBR cord-010092-uftc8inx 4907 22 alert alert JJ cord-010092-uftc8inx 4907 23 to to IN cord-010092-uftc8inx 4907 24 health health NN cord-010092-uftc8inx 4907 25 to to TO cord-010092-uftc8inx 4907 26 participate participate VB cord-010092-uftc8inx 4907 27 more more RBR cord-010092-uftc8inx 4907 28 in in IN cord-010092-uftc8inx 4907 29 donation donation NN cord-010092-uftc8inx 4907 30 programs program NNS cord-010092-uftc8inx 4907 31 or or CC cord-010092-uftc8inx 4907 32 if if IN cord-010092-uftc8inx 4907 33 , , , cord-010092-uftc8inx 4907 34 on on IN cord-010092-uftc8inx 4907 35 the the DT cord-010092-uftc8inx 4907 36 contrary contrary NN cord-010092-uftc8inx 4907 37 , , , cord-010092-uftc8inx 4907 38 the the DT cord-010092-uftc8inx 4907 39 status status NN cord-010092-uftc8inx 4907 40 of of IN cord-010092-uftc8inx 4907 41 regular regular JJ cord-010092-uftc8inx 4907 42 donor donor NN cord-010092-uftc8inx 4907 43 could could MD cord-010092-uftc8inx 4907 44 help help VB cord-010092-uftc8inx 4907 45 the the DT cord-010092-uftc8inx 4907 46 improvement improvement NN cord-010092-uftc8inx 4907 47 of of IN cord-010092-uftc8inx 4907 48 knowledge knowledge NN cord-010092-uftc8inx 4907 49 and and CC cord-010092-uftc8inx 4907 50 healthy healthy JJ cord-010092-uftc8inx 4907 51 lifestyle lifestyle NN cord-010092-uftc8inx 4907 52 . . . cord-010092-uftc8inx 4908 1 Background background NN cord-010092-uftc8inx 4908 2 : : : cord-010092-uftc8inx 4909 1 Donor donor NN cord-010092-uftc8inx 4909 2 recruitment recruitment NN cord-010092-uftc8inx 4909 3 pose pose VBP cord-010092-uftc8inx 4909 4 an an DT cord-010092-uftc8inx 4909 5 ongoing ongoing JJ cord-010092-uftc8inx 4909 6 challenge challenge NN cord-010092-uftc8inx 4909 7 to to IN cord-010092-uftc8inx 4909 8 blood blood NN cord-010092-uftc8inx 4909 9 banks bank NNS cord-010092-uftc8inx 4909 10 worldwide worldwide RB cord-010092-uftc8inx 4909 11 . . . cord-010092-uftc8inx 4910 1 One one CD cord-010092-uftc8inx 4910 2 approach approach NN cord-010092-uftc8inx 4910 3 to to TO cord-010092-uftc8inx 4910 4 improve improve VB cord-010092-uftc8inx 4910 5 the the DT cord-010092-uftc8inx 4910 6 effectiveness effectiveness NN cord-010092-uftc8inx 4910 7 of of IN cord-010092-uftc8inx 4910 8 donor donor NN cord-010092-uftc8inx 4910 9 recruitment recruitment NN cord-010092-uftc8inx 4910 10 is be VBZ cord-010092-uftc8inx 4910 11 to to TO cord-010092-uftc8inx 4910 12 target target VB cord-010092-uftc8inx 4910 13 influencing influence VBG cord-010092-uftc8inx 4910 14 factors factor NNS cord-010092-uftc8inx 4910 15 . . . cord-010092-uftc8inx 4911 1 A a DT cord-010092-uftc8inx 4911 2 yearly yearly JJ cord-010092-uftc8inx 4911 3 league league NN cord-010092-uftc8inx 4911 4 is be VBZ cord-010092-uftc8inx 4911 5 conducted conduct VBN cord-010092-uftc8inx 4911 6 at at IN cord-010092-uftc8inx 4911 7 the the DT cord-010092-uftc8inx 4911 8 Sultan Sultan NNP cord-010092-uftc8inx 4911 9 Qaboos Qaboos NNP cord-010092-uftc8inx 4911 10 University University NNP cord-010092-uftc8inx 4911 11 ( ( -LRB- cord-010092-uftc8inx 4911 12 SQU SQU NNP cord-010092-uftc8inx 4911 13 ) ) -RRB- cord-010092-uftc8inx 4911 14 to to TO cord-010092-uftc8inx 4911 15 encourage encourage VB cord-010092-uftc8inx 4911 16 university university NN cord-010092-uftc8inx 4911 17 students student NNS cord-010092-uftc8inx 4911 18 and and CC cord-010092-uftc8inx 4911 19 faculty faculty NN cord-010092-uftc8inx 4911 20 to to TO cord-010092-uftc8inx 4911 21 donate donate VB cord-010092-uftc8inx 4911 22 blood blood NN cord-010092-uftc8inx 4911 23 . . . cord-010092-uftc8inx 4912 1 During during IN cord-010092-uftc8inx 4912 2 this this DT cord-010092-uftc8inx 4912 3 , , , cord-010092-uftc8inx 4912 4 the the DT cord-010092-uftc8inx 4912 5 colleges college NNS cord-010092-uftc8inx 4912 6 are be VBP cord-010092-uftc8inx 4912 7 evaluated evaluate VBN cord-010092-uftc8inx 4912 8 based base VBN cord-010092-uftc8inx 4912 9 on on IN cord-010092-uftc8inx 4912 10 different different JJ cord-010092-uftc8inx 4912 11 measures measure NNS cord-010092-uftc8inx 4912 12 including include VBG cord-010092-uftc8inx 4912 13 the the DT cord-010092-uftc8inx 4912 14 number number NN cord-010092-uftc8inx 4912 15 of of IN cord-010092-uftc8inx 4912 16 donors donor NNS cord-010092-uftc8inx 4912 17 recruited recruit VBN cord-010092-uftc8inx 4912 18 from from IN cord-010092-uftc8inx 4912 19 each each DT cord-010092-uftc8inx 4912 20 college college NN cord-010092-uftc8inx 4912 21 and and CC cord-010092-uftc8inx 4912 22 the the DT cord-010092-uftc8inx 4912 23 efforts effort NNS cord-010092-uftc8inx 4912 24 made make VBN cord-010092-uftc8inx 4912 25 by by IN cord-010092-uftc8inx 4912 26 the the DT cord-010092-uftc8inx 4912 27 students student NNS cord-010092-uftc8inx 4912 28 in in IN cord-010092-uftc8inx 4912 29 increasing increase VBG cord-010092-uftc8inx 4912 30 the the DT cord-010092-uftc8inx 4912 31 awareness awareness NN cord-010092-uftc8inx 4912 32 of of IN cord-010092-uftc8inx 4912 33 blood blood NN cord-010092-uftc8inx 4912 34 donation donation NN cord-010092-uftc8inx 4912 35 in in IN cord-010092-uftc8inx 4912 36 the the DT cord-010092-uftc8inx 4912 37 colleges college NNS cord-010092-uftc8inx 4912 38 and and CC cord-010092-uftc8inx 4912 39 in in IN cord-010092-uftc8inx 4912 40 the the DT cord-010092-uftc8inx 4912 41 society society NN cord-010092-uftc8inx 4912 42 via via IN cord-010092-uftc8inx 4912 43 different different JJ cord-010092-uftc8inx 4912 44 means mean NNS cord-010092-uftc8inx 4912 45 including include VBG cord-010092-uftc8inx 4912 46 the the DT cord-010092-uftc8inx 4912 47 utilization utilization NN cord-010092-uftc8inx 4912 48 of of IN cord-010092-uftc8inx 4912 49 the the DT cord-010092-uftc8inx 4912 50 social social JJ cord-010092-uftc8inx 4912 51 media medium NNS cord-010092-uftc8inx 4912 52 . . . cord-010092-uftc8inx 4913 1 The the DT cord-010092-uftc8inx 4913 2 whole whole JJ cord-010092-uftc8inx 4913 3 competition competition NN cord-010092-uftc8inx 4913 4 is be VBZ cord-010092-uftc8inx 4913 5 organized organize VBN cord-010092-uftc8inx 4913 6 and and CC cord-010092-uftc8inx 4913 7 ran run VBD cord-010092-uftc8inx 4913 8 by by IN cord-010092-uftc8inx 4913 9 an an DT cord-010092-uftc8inx 4913 10 independent independent JJ cord-010092-uftc8inx 4913 11 group group NN cord-010092-uftc8inx 4913 12 of of IN cord-010092-uftc8inx 4913 13 students student NNS cord-010092-uftc8inx 4913 14 . . . cord-010092-uftc8inx 4914 1 Aims aim VBZ cord-010092-uftc8inx 4914 2 : : : cord-010092-uftc8inx 4915 1 This this DT cord-010092-uftc8inx 4915 2 study study NN cord-010092-uftc8inx 4915 3 aims aim VBZ cord-010092-uftc8inx 4915 4 at at IN cord-010092-uftc8inx 4915 5 studying study VBG cord-010092-uftc8inx 4915 6 the the DT cord-010092-uftc8inx 4915 7 impact impact NN cord-010092-uftc8inx 4915 8 of of IN cord-010092-uftc8inx 4915 9 the the DT cord-010092-uftc8inx 4915 10 yearly yearly JJ cord-010092-uftc8inx 4915 11 SQU SQU NNP cord-010092-uftc8inx 4915 12 college college NN cord-010092-uftc8inx 4915 13 competition competition NN cord-010092-uftc8inx 4915 14 on on IN cord-010092-uftc8inx 4915 15 the the DT cord-010092-uftc8inx 4915 16 perception perception NN cord-010092-uftc8inx 4915 17 of of IN cord-010092-uftc8inx 4915 18 blood blood NN cord-010092-uftc8inx 4915 19 donation donation NN cord-010092-uftc8inx 4915 20 among among IN cord-010092-uftc8inx 4915 21 SQU SQU NNP cord-010092-uftc8inx 4915 22 students student NNS cord-010092-uftc8inx 4915 23 . . . cord-010092-uftc8inx 4916 1 Methods method NNS cord-010092-uftc8inx 4916 2 : : : cord-010092-uftc8inx 4917 1 A a DT cord-010092-uftc8inx 4917 2 comprehensive comprehensive JJ cord-010092-uftc8inx 4917 3 anonymous anonymous JJ cord-010092-uftc8inx 4917 4 voluntary voluntary JJ cord-010092-uftc8inx 4917 5 survey survey NN cord-010092-uftc8inx 4917 6 was be VBD cord-010092-uftc8inx 4917 7 developed develop VBN cord-010092-uftc8inx 4917 8 and and CC cord-010092-uftc8inx 4917 9 used use VBN cord-010092-uftc8inx 4917 10 to to TO cord-010092-uftc8inx 4917 11 assess assess VB cord-010092-uftc8inx 4917 12 perception perception NN cord-010092-uftc8inx 4917 13 of of IN cord-010092-uftc8inx 4917 14 students student NNS cord-010092-uftc8inx 4917 15 aged age VBN cord-010092-uftc8inx 4917 16 18 18 CD cord-010092-uftc8inx 4917 17 - - SYM cord-010092-uftc8inx 4917 18 25 25 CD cord-010092-uftc8inx 4917 19 attending attend VBG cord-010092-uftc8inx 4917 20 SQU SQU NNP cord-010092-uftc8inx 4917 21 and and CC cord-010092-uftc8inx 4917 22 other other JJ cord-010092-uftc8inx 4917 23 universities university NNS cord-010092-uftc8inx 4917 24 ( ( -LRB- cord-010092-uftc8inx 4917 25 non non JJ cord-010092-uftc8inx 4917 26 - - JJ cord-010092-uftc8inx 4917 27 SQU SQU NNP cord-010092-uftc8inx 4917 28 ) ) -RRB- cord-010092-uftc8inx 4917 29 over over IN cord-010092-uftc8inx 4917 30 a a DT cord-010092-uftc8inx 4917 31 two two CD cord-010092-uftc8inx 4917 32 years year NNS cord-010092-uftc8inx 4917 33 ' ' POS cord-010092-uftc8inx 4917 34 period period NN cord-010092-uftc8inx 4917 35 . . . cord-010092-uftc8inx 4918 1 Analysis analysis NN cord-010092-uftc8inx 4918 2 was be VBD cord-010092-uftc8inx 4918 3 performed perform VBN cord-010092-uftc8inx 4918 4 using use VBG cord-010092-uftc8inx 4918 5 IBM IBM NNP cord-010092-uftc8inx 4918 6 SPSS SPSS NNP cord-010092-uftc8inx 4918 7 Statistics Statistics NNP cord-010092-uftc8inx 4918 8 22.0 22.0 CD cord-010092-uftc8inx 4918 9 . . . cord-010092-uftc8inx 4919 1 Categorized categorize VBN cord-010092-uftc8inx 4919 2 variables variable NNS cord-010092-uftc8inx 4919 3 were be VBD cord-010092-uftc8inx 4919 4 presented present VBN cord-010092-uftc8inx 4919 5 in in IN cord-010092-uftc8inx 4919 6 numbers number NNS cord-010092-uftc8inx 4919 7 with with IN cord-010092-uftc8inx 4919 8 percentages percentage NNS cord-010092-uftc8inx 4919 9 and and CC cord-010092-uftc8inx 4919 10 associations association NNS cord-010092-uftc8inx 4919 11 between between IN cord-010092-uftc8inx 4919 12 the the DT cord-010092-uftc8inx 4919 13 groups group NNS cord-010092-uftc8inx 4919 14 were be VBD cord-010092-uftc8inx 4919 15 analyzed analyze VBN cord-010092-uftc8inx 4919 16 using use VBG cord-010092-uftc8inx 4919 17 Chi Chi NNP cord-010092-uftc8inx 4919 18 - - HYPH cord-010092-uftc8inx 4919 19 square square JJ cord-010092-uftc8inx 4919 20 test test NN cord-010092-uftc8inx 4919 21 . . . cord-010092-uftc8inx 4920 1 A a DT cord-010092-uftc8inx 4920 2 P p NN cord-010092-uftc8inx 4920 3 - - HYPH cord-010092-uftc8inx 4920 4 value value NN cord-010092-uftc8inx 4920 5 of of IN cord-010092-uftc8inx 4920 6 < < NNP cord-010092-uftc8inx 4920 7 0.05 0.05 CD cord-010092-uftc8inx 4920 8 was be VBD cord-010092-uftc8inx 4920 9 considered consider VBN cord-010092-uftc8inx 4920 10 statistically statistically RB cord-010092-uftc8inx 4920 11 significant significant JJ cord-010092-uftc8inx 4920 12 . . . cord-010092-uftc8inx 4921 1 Results result NNS cord-010092-uftc8inx 4921 2 : : : cord-010092-uftc8inx 4922 1 A a DT cord-010092-uftc8inx 4922 2 total total NN cord-010092-uftc8inx 4922 3 of of IN cord-010092-uftc8inx 4922 4 600 600 CD cord-010092-uftc8inx 4922 5 students student NNS cord-010092-uftc8inx 4922 6 were be VBD cord-010092-uftc8inx 4922 7 surveyed survey VBN cord-010092-uftc8inx 4922 8 ( ( -LRB- cord-010092-uftc8inx 4922 9 300 300 CD cord-010092-uftc8inx 4922 10 SQU SQU NNP cord-010092-uftc8inx 4922 11 , , , cord-010092-uftc8inx 4922 12 300 300 CD cord-010092-uftc8inx 4922 13 non non JJ cord-010092-uftc8inx 4922 14 - - JJ cord-010092-uftc8inx 4922 15 SQU SQU NNP cord-010092-uftc8inx 4922 16 ) ) -RRB- cord-010092-uftc8inx 4922 17 . . . cord-010092-uftc8inx 4923 1 There there EX cord-010092-uftc8inx 4923 2 was be VBD cord-010092-uftc8inx 4923 3 no no DT cord-010092-uftc8inx 4923 4 statistical statistical JJ cord-010092-uftc8inx 4923 5 difference difference NN cord-010092-uftc8inx 4923 6 between between IN cord-010092-uftc8inx 4923 7 SQU SQU NNP cord-010092-uftc8inx 4923 8 and and CC cord-010092-uftc8inx 4923 9 non non JJ cord-010092-uftc8inx 4923 10 - - JJ cord-010092-uftc8inx 4923 11 SQU squ JJ cord-010092-uftc8inx 4923 12 students student NNS cord-010092-uftc8inx 4923 13 with with IN cord-010092-uftc8inx 4923 14 regard regard NN cord-010092-uftc8inx 4923 15 to to IN cord-010092-uftc8inx 4923 16 past past JJ cord-010092-uftc8inx 4923 17 history history NN cord-010092-uftc8inx 4923 18 of of IN cord-010092-uftc8inx 4923 19 blood blood NN cord-010092-uftc8inx 4923 20 donation donation NN cord-010092-uftc8inx 4923 21 and and CC cord-010092-uftc8inx 4923 22 the the DT cord-010092-uftc8inx 4923 23 number number NN cord-010092-uftc8inx 4923 24 of of IN cord-010092-uftc8inx 4923 25 donations donation NNS cord-010092-uftc8inx 4923 26 made make VBN cord-010092-uftc8inx 4923 27 . . . cord-010092-uftc8inx 4924 1 When when WRB cord-010092-uftc8inx 4924 2 comparing compare VBG cord-010092-uftc8inx 4924 3 between between IN cord-010092-uftc8inx 4924 4 both both DT cord-010092-uftc8inx 4924 5 cohorts cohort NNS cord-010092-uftc8inx 4924 6 , , , cord-010092-uftc8inx 4924 7 73 73 CD cord-010092-uftc8inx 4924 8 % % NN cord-010092-uftc8inx 4924 9 of of IN cord-010092-uftc8inx 4924 10 the the DT cord-010092-uftc8inx 4924 11 SQU SQU NNP cord-010092-uftc8inx 4924 12 and and CC cord-010092-uftc8inx 4924 13 25 25 CD cord-010092-uftc8inx 4924 14 % % NN cord-010092-uftc8inx 4924 15 of of IN cord-010092-uftc8inx 4924 16 non non JJ cord-010092-uftc8inx 4924 17 - - JJ cord-010092-uftc8inx 4924 18 SQU squ JJ cord-010092-uftc8inx 4924 19 students student NNS cord-010092-uftc8inx 4924 20 reported report VBD cord-010092-uftc8inx 4924 21 the the DT cord-010092-uftc8inx 4924 22 university university NN cord-010092-uftc8inx 4924 23 as as IN cord-010092-uftc8inx 4924 24 the the DT cord-010092-uftc8inx 4924 25 main main JJ cord-010092-uftc8inx 4924 26 source source NN cord-010092-uftc8inx 4924 27 for for IN cord-010092-uftc8inx 4924 28 information information NN cord-010092-uftc8inx 4924 29 ( ( -LRB- cord-010092-uftc8inx 4924 30 P p NN cord-010092-uftc8inx 4924 31 < < XX cord-010092-uftc8inx 4924 32 0.001 0.001 CD cord-010092-uftc8inx 4924 33 ) ) -RRB- cord-010092-uftc8inx 4924 34 , , , cord-010092-uftc8inx 4924 35 while while IN cord-010092-uftc8inx 4924 36 56 56 CD cord-010092-uftc8inx 4924 37 % % NN cord-010092-uftc8inx 4924 38 of of IN cord-010092-uftc8inx 4924 39 SQU SQU NNP cord-010092-uftc8inx 4924 40 and and CC cord-010092-uftc8inx 4924 41 45 45 CD cord-010092-uftc8inx 4924 42 % % NN cord-010092-uftc8inx 4924 43 of of IN cord-010092-uftc8inx 4924 44 non non JJ cord-010092-uftc8inx 4924 45 - - JJ cord-010092-uftc8inx 4924 46 SQU squ JJ cord-010092-uftc8inx 4924 47 students student NNS cord-010092-uftc8inx 4924 48 reported report VBD cord-010092-uftc8inx 4924 49 that that IN cord-010092-uftc8inx 4924 50 the the DT cord-010092-uftc8inx 4924 51 social social JJ cord-010092-uftc8inx 4924 52 media medium NNS cord-010092-uftc8inx 4924 53 was be VBD cord-010092-uftc8inx 4924 54 the the DT cord-010092-uftc8inx 4924 55 main main JJ cord-010092-uftc8inx 4924 56 source source NN cord-010092-uftc8inx 4924 57 respectively respectively RB cord-010092-uftc8inx 4924 58 ( ( -LRB- cord-010092-uftc8inx 4924 59 P p NN cord-010092-uftc8inx 4924 60 = = SYM cord-010092-uftc8inx 4924 61 0.048 0.048 CD cord-010092-uftc8inx 4924 62 ) ) -RRB- cord-010092-uftc8inx 4924 63 . . . cord-010092-uftc8inx 4925 1 There there EX cord-010092-uftc8inx 4925 2 was be VBD cord-010092-uftc8inx 4925 3 no no DT cord-010092-uftc8inx 4925 4 statistical statistical JJ cord-010092-uftc8inx 4925 5 difference difference NN cord-010092-uftc8inx 4925 6 between between IN cord-010092-uftc8inx 4925 7 male male JJ cord-010092-uftc8inx 4925 8 and and CC cord-010092-uftc8inx 4925 9 female female JJ cord-010092-uftc8inx 4925 10 donors donor NNS cord-010092-uftc8inx 4925 11 on on IN cord-010092-uftc8inx 4925 12 their -PRON- PRP$ cord-010092-uftc8inx 4925 13 perception perception NN cord-010092-uftc8inx 4925 14 of of IN cord-010092-uftc8inx 4925 15 level level NN cord-010092-uftc8inx 4925 16 of of IN cord-010092-uftc8inx 4925 17 self self NN cord-010092-uftc8inx 4925 18 - - HYPH cord-010092-uftc8inx 4925 19 knowledge knowledge NN cord-010092-uftc8inx 4925 20 on on IN cord-010092-uftc8inx 4925 21 blood blood NN cord-010092-uftc8inx 4925 22 donation donation NN cord-010092-uftc8inx 4925 23 ( ( -LRB- cord-010092-uftc8inx 4925 24 P p NN cord-010092-uftc8inx 4925 25 = = SYM cord-010092-uftc8inx 4925 26 0.868 0.868 CD cord-010092-uftc8inx 4925 27 ) ) -RRB- cord-010092-uftc8inx 4925 28 . . . cord-010092-uftc8inx 4926 1 About about RB cord-010092-uftc8inx 4926 2 84 84 CD cord-010092-uftc8inx 4926 3 % % NN cord-010092-uftc8inx 4926 4 of of IN cord-010092-uftc8inx 4926 5 the the DT cord-010092-uftc8inx 4926 6 youth youth NN cord-010092-uftc8inx 4926 7 agreed agree VBD cord-010092-uftc8inx 4926 8 that that IN cord-010092-uftc8inx 4926 9 blood blood NN cord-010092-uftc8inx 4926 10 donation donation NN cord-010092-uftc8inx 4926 11 is be VBZ cord-010092-uftc8inx 4926 12 one one CD cord-010092-uftc8inx 4926 13 of of IN cord-010092-uftc8inx 4926 14 the the DT cord-010092-uftc8inx 4926 15 duties duty NNS cord-010092-uftc8inx 4926 16 toward toward IN cord-010092-uftc8inx 4926 17 the the DT cord-010092-uftc8inx 4926 18 community community NN cord-010092-uftc8inx 4926 19 . . . cord-010092-uftc8inx 4927 1 SQU SQU NNP cord-010092-uftc8inx 4927 2 students student NNS cord-010092-uftc8inx 4927 3 reported report VBD cord-010092-uftc8inx 4927 4 higher high JJR cord-010092-uftc8inx 4927 5 rates rate NNS cord-010092-uftc8inx 4927 6 of of IN cord-010092-uftc8inx 4927 7 respond respond NNS cord-010092-uftc8inx 4927 8 to to IN cord-010092-uftc8inx 4927 9 specific specific JJ cord-010092-uftc8inx 4927 10 requests request NNS cord-010092-uftc8inx 4927 11 for for IN cord-010092-uftc8inx 4927 12 blood blood NN cord-010092-uftc8inx 4927 13 donation donation NN cord-010092-uftc8inx 4927 14 ( ( -LRB- cord-010092-uftc8inx 4927 15 44.3 44.3 CD cord-010092-uftc8inx 4927 16 % % NN cord-010092-uftc8inx 4927 17 vs vs IN cord-010092-uftc8inx 4927 18 29.7 29.7 CD cord-010092-uftc8inx 4927 19 % % NN cord-010092-uftc8inx 4927 20 , , , cord-010092-uftc8inx 4927 21 P p NN cord-010092-uftc8inx 4927 22 < < XX cord-010092-uftc8inx 4927 23 0.001 0.001 CD cord-010092-uftc8inx 4927 24 ) ) -RRB- cord-010092-uftc8inx 4927 25 . . . cord-010092-uftc8inx 4928 1 SQU SQU NNP cord-010092-uftc8inx 4928 2 students student NNS cord-010092-uftc8inx 4928 3 reported report VBD cord-010092-uftc8inx 4928 4 greater great JJR cord-010092-uftc8inx 4928 5 influence influence NN cord-010092-uftc8inx 4928 6 of of IN cord-010092-uftc8inx 4928 7 peers peer NNS cord-010092-uftc8inx 4928 8 ( ( -LRB- cord-010092-uftc8inx 4928 9 84 84 CD cord-010092-uftc8inx 4928 10 % % NN cord-010092-uftc8inx 4928 11 vs vs IN cord-010092-uftc8inx 4928 12 60.7 60.7 CD cord-010092-uftc8inx 4928 13 % % NN cord-010092-uftc8inx 4928 14 , , , cord-010092-uftc8inx 4928 15 P p NN cord-010092-uftc8inx 4928 16 < < XX cord-010092-uftc8inx 4928 17 0.001 0.001 CD cord-010092-uftc8inx 4928 18 ) ) -RRB- cord-010092-uftc8inx 4928 19 , , , cord-010092-uftc8inx 4928 20 personal personal JJ cord-010092-uftc8inx 4928 21 knowledge knowledge NN cord-010092-uftc8inx 4928 22 ( ( -LRB- cord-010092-uftc8inx 4928 23 82 82 CD cord-010092-uftc8inx 4928 24 % % NN cord-010092-uftc8inx 4928 25 vs vs IN cord-010092-uftc8inx 4928 26 74.7 74.7 CD cord-010092-uftc8inx 4928 27 % % NN cord-010092-uftc8inx 4928 28 , , , cord-010092-uftc8inx 4928 29 P p NN cord-010092-uftc8inx 4928 30 = = SYM cord-010092-uftc8inx 4928 31 0.029 0.029 CD cord-010092-uftc8inx 4928 32 ) ) -RRB- cord-010092-uftc8inx 4928 33 and and CC cord-010092-uftc8inx 4928 34 personal personal JJ cord-010092-uftc8inx 4928 35 experience experience NN cord-010092-uftc8inx 4928 36 ( ( -LRB- cord-010092-uftc8inx 4928 37 79.3 79.3 CD cord-010092-uftc8inx 4928 38 % % NN cord-010092-uftc8inx 4928 39 vs vs IN cord-010092-uftc8inx 4928 40 69 69 CD cord-010092-uftc8inx 4928 41 % % NN cord-010092-uftc8inx 4928 42 , , , cord-010092-uftc8inx 4928 43 P p NN cord-010092-uftc8inx 4928 44 = = SYM cord-010092-uftc8inx 4928 45 0.005 0.005 CD cord-010092-uftc8inx 4928 46 ) ) -RRB- cord-010092-uftc8inx 4928 47 when when WRB cord-010092-uftc8inx 4928 48 compared compare VBN cord-010092-uftc8inx 4928 49 to to IN cord-010092-uftc8inx 4928 50 non non JJ cord-010092-uftc8inx 4928 51 - - JJ cord-010092-uftc8inx 4928 52 SQU squ JJ cord-010092-uftc8inx 4928 53 students student NNS cord-010092-uftc8inx 4928 54 . . . cord-010092-uftc8inx 4929 1 They -PRON- PRP cord-010092-uftc8inx 4929 2 also also RB cord-010092-uftc8inx 4929 3 reported report VBD cord-010092-uftc8inx 4929 4 more more JJR cord-010092-uftc8inx 4929 5 feeling feeling NN cord-010092-uftc8inx 4929 6 of of IN cord-010092-uftc8inx 4929 7 commitment commitment NN cord-010092-uftc8inx 4929 8 to to IN cord-010092-uftc8inx 4929 9 the the DT cord-010092-uftc8inx 4929 10 society society NN cord-010092-uftc8inx 4929 11 ( ( -LRB- cord-010092-uftc8inx 4929 12 90.3 90.3 CD cord-010092-uftc8inx 4929 13 % % NN cord-010092-uftc8inx 4929 14 vs vs IN cord-010092-uftc8inx 4929 15 78 78 CD cord-010092-uftc8inx 4929 16 % % NN cord-010092-uftc8inx 4929 17 , , , cord-010092-uftc8inx 4929 18 P p NN cord-010092-uftc8inx 4929 19 < < XX cord-010092-uftc8inx 4929 20 0.001 0.001 CD cord-010092-uftc8inx 4929 21 ) ) -RRB- cord-010092-uftc8inx 4929 22 . . . cord-010092-uftc8inx 4930 1 SQU SQU NNP cord-010092-uftc8inx 4930 2 students student NNS cord-010092-uftc8inx 4930 3 reported report VBD cord-010092-uftc8inx 4930 4 lower low JJR cord-010092-uftc8inx 4930 5 influence influence NN cord-010092-uftc8inx 4930 6 of of IN cord-010092-uftc8inx 4930 7 parents parent NNS cord-010092-uftc8inx 4930 8 ( ( -LRB- cord-010092-uftc8inx 4930 9 53 53 CD cord-010092-uftc8inx 4930 10 % % NN cord-010092-uftc8inx 4930 11 vs vs IN cord-010092-uftc8inx 4930 12 65 65 CD cord-010092-uftc8inx 4930 13 % % NN cord-010092-uftc8inx 4930 14 , , , cord-010092-uftc8inx 4930 15 P p NN cord-010092-uftc8inx 4930 16 = = SYM cord-010092-uftc8inx 4930 17 0.005 0.005 CD cord-010092-uftc8inx 4930 18 ) ) -RRB- cord-010092-uftc8inx 4930 19 , , , cord-010092-uftc8inx 4930 20 lower low JJR cord-010092-uftc8inx 4930 21 rates rate NNS cord-010092-uftc8inx 4930 22 of of IN cord-010092-uftc8inx 4930 23 fear fear NN cord-010092-uftc8inx 4930 24 from from IN cord-010092-uftc8inx 4930 25 needles needle NNS cord-010092-uftc8inx 4930 26 ( ( -LRB- cord-010092-uftc8inx 4930 27 18 18 CD cord-010092-uftc8inx 4930 28 % % NN cord-010092-uftc8inx 4930 29 vs vs IN cord-010092-uftc8inx 4930 30 32 32 CD cord-010092-uftc8inx 4930 31 % % NN cord-010092-uftc8inx 4930 32 , , , cord-010092-uftc8inx 4930 33 P p NN cord-010092-uftc8inx 4930 34 < < XX cord-010092-uftc8inx 4930 35 0.001 0.001 CD cord-010092-uftc8inx 4930 36 ) ) -RRB- cord-010092-uftc8inx 4930 37 and and CC cord-010092-uftc8inx 4930 38 lower low JJR cord-010092-uftc8inx 4930 39 rates rate NNS cord-010092-uftc8inx 4930 40 of of IN cord-010092-uftc8inx 4930 41 fear fear NN cord-010092-uftc8inx 4930 42 from from IN cord-010092-uftc8inx 4930 43 blood blood NN cord-010092-uftc8inx 4930 44 ( ( -LRB- cord-010092-uftc8inx 4930 45 16 16 CD cord-010092-uftc8inx 4930 46 % % NN cord-010092-uftc8inx 4930 47 vs vs IN cord-010092-uftc8inx 4930 48 29 29 CD cord-010092-uftc8inx 4930 49 % % NN cord-010092-uftc8inx 4930 50 , , , cord-010092-uftc8inx 4930 51 P p NN cord-010092-uftc8inx 4930 52 < < XX cord-010092-uftc8inx 4930 53 0.001 0.001 CD cord-010092-uftc8inx 4930 54 ) ) -RRB- cord-010092-uftc8inx 4930 55 . . . cord-010092-uftc8inx 4931 1 There there EX cord-010092-uftc8inx 4931 2 was be VBD cord-010092-uftc8inx 4931 3 no no DT cord-010092-uftc8inx 4931 4 difference difference NN cord-010092-uftc8inx 4931 5 between between IN cord-010092-uftc8inx 4931 6 male male JJ cord-010092-uftc8inx 4931 7 and and CC cord-010092-uftc8inx 4931 8 female female JJ cord-010092-uftc8inx 4931 9 genders gender NNS cord-010092-uftc8inx 4931 10 in in IN cord-010092-uftc8inx 4931 11 any any DT cord-010092-uftc8inx 4931 12 of of IN cord-010092-uftc8inx 4931 13 the the DT cord-010092-uftc8inx 4931 14 discouraging discouraging JJ cord-010092-uftc8inx 4931 15 factors factor NNS cord-010092-uftc8inx 4931 16 . . . cord-010092-uftc8inx 4932 1 Summary Summary NNP cord-010092-uftc8inx 4932 2 / / SYM cord-010092-uftc8inx 4932 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 4932 4 : : : cord-010092-uftc8inx 4933 1 These these DT cord-010092-uftc8inx 4933 2 results result NNS cord-010092-uftc8inx 4933 3 highlighted highlight VBD cord-010092-uftc8inx 4933 4 the the DT cord-010092-uftc8inx 4933 5 positive positive JJ cord-010092-uftc8inx 4933 6 impact impact NN cord-010092-uftc8inx 4933 7 and and CC cord-010092-uftc8inx 4933 8 important important JJ cord-010092-uftc8inx 4933 9 rule rule NN cord-010092-uftc8inx 4933 10 of of IN cord-010092-uftc8inx 4933 11 the the DT cord-010092-uftc8inx 4933 12 youth youth NN cord-010092-uftc8inx 4933 13 in in IN cord-010092-uftc8inx 4933 14 the the DT cord-010092-uftc8inx 4933 15 promoting promote VBG cord-010092-uftc8inx 4933 16 blood blood NN cord-010092-uftc8inx 4933 17 donations donation NNS cord-010092-uftc8inx 4933 18 among among IN cord-010092-uftc8inx 4933 19 themselves -PRON- PRP cord-010092-uftc8inx 4933 20 through through IN cord-010092-uftc8inx 4933 21 this this DT cord-010092-uftc8inx 4933 22 yearly yearly JJ cord-010092-uftc8inx 4933 23 college college NN cord-010092-uftc8inx 4933 24 competition competition NN cord-010092-uftc8inx 4933 25 ; ; : cord-010092-uftc8inx 4933 26 in in IN cord-010092-uftc8inx 4933 27 recruiting recruit VBG cord-010092-uftc8inx 4933 28 blood blood NN cord-010092-uftc8inx 4933 29 donors donor NNS cord-010092-uftc8inx 4933 30 and and CC cord-010092-uftc8inx 4933 31 in in IN cord-010092-uftc8inx 4933 32 the the DT cord-010092-uftc8inx 4933 33 dissemination dissemination NN cord-010092-uftc8inx 4933 34 of of IN cord-010092-uftc8inx 4933 35 the the DT cord-010092-uftc8inx 4933 36 knowledge knowledge NN cord-010092-uftc8inx 4933 37 of of IN cord-010092-uftc8inx 4933 38 blood blood NN cord-010092-uftc8inx 4933 39 donation donation NN cord-010092-uftc8inx 4933 40 . . . cord-010092-uftc8inx 4934 1 Distinct distinct JJ cord-010092-uftc8inx 4934 2 promotion promotion NN cord-010092-uftc8inx 4934 3 strategies strategy NNS cord-010092-uftc8inx 4934 4 should should MD cord-010092-uftc8inx 4934 5 be be VB cord-010092-uftc8inx 4934 6 adopted adopt VBN cord-010092-uftc8inx 4934 7 to to IN cord-010092-uftc8inx 4934 8 increased increase VBN cord-010092-uftc8inx 4934 9 first first JJ cord-010092-uftc8inx 4934 10 time time NN cord-010092-uftc8inx 4934 11 and and CC cord-010092-uftc8inx 4934 12 repeated repeat VBD cord-010092-uftc8inx 4934 13 blood blood NN cord-010092-uftc8inx 4934 14 donation donation NN cord-010092-uftc8inx 4934 15 among among IN cord-010092-uftc8inx 4934 16 the the DT cord-010092-uftc8inx 4934 17 youth youth NN cord-010092-uftc8inx 4934 18 . . . cord-010092-uftc8inx 4935 1 We -PRON- PRP cord-010092-uftc8inx 4935 2 advocate advocate VBP cord-010092-uftc8inx 4935 3 for for IN cord-010092-uftc8inx 4935 4 similar similar JJ cord-010092-uftc8inx 4935 5 initiatives initiative NNS cord-010092-uftc8inx 4935 6 in in IN cord-010092-uftc8inx 4935 7 encouraging encourage VBG cord-010092-uftc8inx 4935 8 blood blood NN cord-010092-uftc8inx 4935 9 donation donation NN cord-010092-uftc8inx 4935 10 and and CC cord-010092-uftc8inx 4935 11 disseminate disseminate VB cord-010092-uftc8inx 4935 12 knowledge knowledge NN cord-010092-uftc8inx 4935 13 among among IN cord-010092-uftc8inx 4935 14 individuals individual NNS cord-010092-uftc8inx 4935 15 in in IN cord-010092-uftc8inx 4935 16 the the DT cord-010092-uftc8inx 4935 17 community community NN cord-010092-uftc8inx 4935 18 . . . cord-010092-uftc8inx 4936 1 Dubai Dubai NNP cord-010092-uftc8inx 4936 2 Blood Blood NNP cord-010092-uftc8inx 4936 3 Donation Donation NNP cord-010092-uftc8inx 4936 4 Center Center NNP cord-010092-uftc8inx 4936 5 , , , cord-010092-uftc8inx 4936 6 Dubai Dubai NNP cord-010092-uftc8inx 4936 7 Health Health NNP cord-010092-uftc8inx 4936 8 Authority Authority NNP cord-010092-uftc8inx 4936 9 , , , cord-010092-uftc8inx 4936 10 Dubai Dubai NNP cord-010092-uftc8inx 4936 11 , , , cord-010092-uftc8inx 4936 12 United United NNP cord-010092-uftc8inx 4936 13 Arab Arab NNP cord-010092-uftc8inx 4936 14 Emirates Emirates NNP cord-010092-uftc8inx 4936 15 Background Background NNP cord-010092-uftc8inx 4936 16 : : : cord-010092-uftc8inx 4937 1 Dubai Dubai NNP cord-010092-uftc8inx 4937 2 is be VBZ cord-010092-uftc8inx 4937 3 multicultural multicultural JJ cord-010092-uftc8inx 4937 4 city city NN cord-010092-uftc8inx 4937 5 in in IN cord-010092-uftc8inx 4937 6 United United NNP cord-010092-uftc8inx 4937 7 Arab Arab NNP cord-010092-uftc8inx 4937 8 Emirates Emirates NNPS cord-010092-uftc8inx 4937 9 . . . cord-010092-uftc8inx 4938 1 Only only RB cord-010092-uftc8inx 4938 2 about about IN cord-010092-uftc8inx 4938 3 15 15 CD cord-010092-uftc8inx 4938 4 % % NN cord-010092-uftc8inx 4938 5 of of IN cord-010092-uftc8inx 4938 6 the the DT cord-010092-uftc8inx 4938 7 population population NN cord-010092-uftc8inx 4938 8 consists consist VBZ cord-010092-uftc8inx 4938 9 of of IN cord-010092-uftc8inx 4938 10 UAE UAE NNP cord-010092-uftc8inx 4938 11 nationals national NNS cord-010092-uftc8inx 4938 12 with with IN cord-010092-uftc8inx 4938 13 the the DT cord-010092-uftc8inx 4938 14 rest rest NN cord-010092-uftc8inx 4938 15 comprising comprise VBG cord-010092-uftc8inx 4938 16 expatriates expatriate NNS cord-010092-uftc8inx 4938 17 from from IN cord-010092-uftc8inx 4938 18 various various JJ cord-010092-uftc8inx 4938 19 countries country NNS cord-010092-uftc8inx 4938 20 all all RB cord-010092-uftc8inx 4938 21 over over IN cord-010092-uftc8inx 4938 22 the the DT cord-010092-uftc8inx 4938 23 world world NN cord-010092-uftc8inx 4938 24 . . . cord-010092-uftc8inx 4939 1 Approximately approximately RB cord-010092-uftc8inx 4939 2 85 85 CD cord-010092-uftc8inx 4939 3 % % NN cord-010092-uftc8inx 4939 4 of of IN cord-010092-uftc8inx 4939 5 the the DT cord-010092-uftc8inx 4939 6 expatriate expatriate JJ cord-010092-uftc8inx 4939 7 population population NN cord-010092-uftc8inx 4939 8 ( ( -LRB- cord-010092-uftc8inx 4939 9 and and CC cord-010092-uftc8inx 4939 10 71 71 CD cord-010092-uftc8inx 4939 11 % % NN cord-010092-uftc8inx 4939 12 of of IN cord-010092-uftc8inx 4939 13 the the DT cord-010092-uftc8inx 4939 14 emirate emirate NN cord-010092-uftc8inx 4939 15 's 's POS cord-010092-uftc8inx 4939 16 total total JJ cord-010092-uftc8inx 4939 17 population population NN cord-010092-uftc8inx 4939 18 ) ) -RRB- cord-010092-uftc8inx 4939 19 are be VBP cord-010092-uftc8inx 4939 20 Asian asian JJ cord-010092-uftc8inx 4939 21 , , , cord-010092-uftc8inx 4939 22 chiefly chiefly RB cord-010092-uftc8inx 4939 23 Indian indian JJ cord-010092-uftc8inx 4939 24 ( ( -LRB- cord-010092-uftc8inx 4939 25 51 51 CD cord-010092-uftc8inx 4939 26 % % NN cord-010092-uftc8inx 4939 27 ) ) -RRB- cord-010092-uftc8inx 4939 28 and and CC cord-010092-uftc8inx 4939 29 Pakistani pakistani JJ cord-010092-uftc8inx 4939 30 ( ( -LRB- cord-010092-uftc8inx 4939 31 16 16 CD cord-010092-uftc8inx 4939 32 % % NN cord-010092-uftc8inx 4939 33 ) ) -RRB- cord-010092-uftc8inx 4939 34 . . . cord-010092-uftc8inx 4940 1 Dubai Dubai NNP cord-010092-uftc8inx 4940 2 Blood Blood NNP cord-010092-uftc8inx 4940 3 Donation Donation NNP cord-010092-uftc8inx 4940 4 centre centre NN cord-010092-uftc8inx 4940 5 is be VBZ cord-010092-uftc8inx 4940 6 the the DT cord-010092-uftc8inx 4940 7 only only JJ cord-010092-uftc8inx 4940 8 centre centre NN cord-010092-uftc8inx 4940 9 providing provide VBG cord-010092-uftc8inx 4940 10 blood blood NN cord-010092-uftc8inx 4940 11 donation donation NN cord-010092-uftc8inx 4940 12 services service NNS cord-010092-uftc8inx 4940 13 in in IN cord-010092-uftc8inx 4940 14 Dubai Dubai NNP cord-010092-uftc8inx 4940 15 . . . cord-010092-uftc8inx 4941 1 Arabic Arabic NNP cord-010092-uftc8inx 4941 2 is be VBZ cord-010092-uftc8inx 4942 1 the the DT cord-010092-uftc8inx 4942 2 national national JJ cord-010092-uftc8inx 4942 3 and and CC cord-010092-uftc8inx 4942 4 official official JJ cord-010092-uftc8inx 4942 5 language language NN cord-010092-uftc8inx 4942 6 and and CC cord-010092-uftc8inx 4942 7 English English NNP cord-010092-uftc8inx 4942 8 is be VBZ cord-010092-uftc8inx 4942 9 used use VBN cord-010092-uftc8inx 4942 10 as as IN cord-010092-uftc8inx 4942 11 a a DT cord-010092-uftc8inx 4942 12 second second JJ cord-010092-uftc8inx 4942 13 language language NN cord-010092-uftc8inx 4942 14 . . . cord-010092-uftc8inx 4943 1 In in IN cord-010092-uftc8inx 4943 2 order order NN cord-010092-uftc8inx 4943 3 to to TO cord-010092-uftc8inx 4943 4 have have VB cord-010092-uftc8inx 4943 5 good good JJ cord-010092-uftc8inx 4943 6 quality quality NN cord-010092-uftc8inx 4943 7 screening screening NN cord-010092-uftc8inx 4943 8 , , , cord-010092-uftc8inx 4943 9 it -PRON- PRP cord-010092-uftc8inx 4943 10 is be VBZ cord-010092-uftc8inx 4943 11 important important JJ cord-010092-uftc8inx 4943 12 that that IN cord-010092-uftc8inx 4943 13 blood blood NN cord-010092-uftc8inx 4943 14 donors donor NNS cord-010092-uftc8inx 4943 15 understand understand VBP cord-010092-uftc8inx 4943 16 the the DT cord-010092-uftc8inx 4943 17 educational educational JJ cord-010092-uftc8inx 4943 18 material material NN cord-010092-uftc8inx 4943 19 and and CC cord-010092-uftc8inx 4943 20 questionnaire questionnaire NN cord-010092-uftc8inx 4943 21 properly properly RB cord-010092-uftc8inx 4943 22 . . . cord-010092-uftc8inx 4944 1 Aims aim VBZ cord-010092-uftc8inx 4944 2 : : : cord-010092-uftc8inx 4945 1 Dubai Dubai NNP cord-010092-uftc8inx 4945 2 Blood Blood NNP cord-010092-uftc8inx 4945 3 Donation Donation NNP cord-010092-uftc8inx 4945 4 Centre Centre NNP cord-010092-uftc8inx 4945 5 receives receive VBZ cord-010092-uftc8inx 4945 6 donors donor NNS cord-010092-uftc8inx 4945 7 ( ( -LRB- cord-010092-uftc8inx 4945 8 Nationals Nationals NNPS cord-010092-uftc8inx 4945 9 , , , cord-010092-uftc8inx 4945 10 Residents Residents NNPS cord-010092-uftc8inx 4945 11 and and CC cord-010092-uftc8inx 4945 12 GCC GCC NNP cord-010092-uftc8inx 4945 13 card card NN cord-010092-uftc8inx 4945 14 holders holder NNS cord-010092-uftc8inx 4945 15 ) ) -RRB- cord-010092-uftc8inx 4945 16 from from IN cord-010092-uftc8inx 4945 17 various various JJ cord-010092-uftc8inx 4945 18 countries country NNS cord-010092-uftc8inx 4945 19 . . . cord-010092-uftc8inx 4946 1 The the DT cord-010092-uftc8inx 4946 2 aim aim NN cord-010092-uftc8inx 4946 3 of of IN cord-010092-uftc8inx 4946 4 this this DT cord-010092-uftc8inx 4946 5 study study NN cord-010092-uftc8inx 4946 6 is be VBZ cord-010092-uftc8inx 4946 7 to to TO cord-010092-uftc8inx 4946 8 analyze analyze VB cord-010092-uftc8inx 4946 9 the the DT cord-010092-uftc8inx 4946 10 multinational multinational JJ cord-010092-uftc8inx 4946 11 profile profile NN cord-010092-uftc8inx 4946 12 of of IN cord-010092-uftc8inx 4946 13 donors donor NNS cord-010092-uftc8inx 4946 14 and and CC cord-010092-uftc8inx 4946 15 to to TO cord-010092-uftc8inx 4946 16 find find VB cord-010092-uftc8inx 4946 17 out out RP cord-010092-uftc8inx 4946 18 the the DT cord-010092-uftc8inx 4946 19 need need NN cord-010092-uftc8inx 4946 20 to to TO cord-010092-uftc8inx 4946 21 add add VB cord-010092-uftc8inx 4946 22 any any DT cord-010092-uftc8inx 4946 23 third third JJ cord-010092-uftc8inx 4946 24 language language NN cord-010092-uftc8inx 4946 25 to to TO cord-010092-uftc8inx 4946 26 meet meet VB cord-010092-uftc8inx 4946 27 the the DT cord-010092-uftc8inx 4946 28 customer customer NN cord-010092-uftc8inx 4946 29 needs need NNS cord-010092-uftc8inx 4946 30 and and CC cord-010092-uftc8inx 4946 31 expectations expectation NNS cord-010092-uftc8inx 4946 32 . . . cord-010092-uftc8inx 4947 1 Methods method NNS cord-010092-uftc8inx 4947 2 : : : cord-010092-uftc8inx 4948 1 A a DT cord-010092-uftc8inx 4948 2 cross cross JJ cord-010092-uftc8inx 4948 3 - - JJ cord-010092-uftc8inx 4948 4 sectional sectional JJ cord-010092-uftc8inx 4948 5 study study NN cord-010092-uftc8inx 4948 6 of of IN cord-010092-uftc8inx 4948 7 blood blood NN cord-010092-uftc8inx 4948 8 donors donor NNS cord-010092-uftc8inx 4948 9 was be VBD cord-010092-uftc8inx 4948 10 conducted conduct VBN cord-010092-uftc8inx 4948 11 in in IN cord-010092-uftc8inx 4948 12 Dubai Dubai NNP cord-010092-uftc8inx 4948 13 Blood Blood NNP cord-010092-uftc8inx 4948 14 Donation Donation NNP cord-010092-uftc8inx 4948 15 Centre Centre NNP cord-010092-uftc8inx 4948 16 in in IN cord-010092-uftc8inx 4948 17 2019 2019 CD cord-010092-uftc8inx 4948 18 . . . cord-010092-uftc8inx 4949 1 The the DT cord-010092-uftc8inx 4949 2 donors donor NNS cord-010092-uftc8inx 4949 3 were be VBD cord-010092-uftc8inx 4949 4 asked ask VBN cord-010092-uftc8inx 4949 5 about about IN cord-010092-uftc8inx 4949 6 their -PRON- PRP$ cord-010092-uftc8inx 4949 7 country country NN cord-010092-uftc8inx 4949 8 of of IN cord-010092-uftc8inx 4949 9 origin origin NN cord-010092-uftc8inx 4949 10 , , , cord-010092-uftc8inx 4949 11 languages language NNS cord-010092-uftc8inx 4949 12 which which WDT cord-010092-uftc8inx 4949 13 they -PRON- PRP cord-010092-uftc8inx 4949 14 can can MD cord-010092-uftc8inx 4949 15 read read VB cord-010092-uftc8inx 4949 16 & & CC cord-010092-uftc8inx 4949 17 understand understand VB cord-010092-uftc8inx 4949 18 and and CC cord-010092-uftc8inx 4949 19 about about IN cord-010092-uftc8inx 4949 20 the the DT cord-010092-uftc8inx 4949 21 preferred preferred JJ cord-010092-uftc8inx 4949 22 mode mode NN cord-010092-uftc8inx 4949 23 of of IN cord-010092-uftc8inx 4949 24 communication communication NN cord-010092-uftc8inx 4949 25 . . . cord-010092-uftc8inx 4950 1 Results result NNS cord-010092-uftc8inx 4950 2 : : : cord-010092-uftc8inx 4951 1 A a DT cord-010092-uftc8inx 4951 2 total total NN cord-010092-uftc8inx 4951 3 of of IN cord-010092-uftc8inx 4951 4 1080 1080 CD cord-010092-uftc8inx 4951 5 donors donor NNS cord-010092-uftc8inx 4951 6 were be VBD cord-010092-uftc8inx 4951 7 surveyed survey VBN cord-010092-uftc8inx 4951 8 and and CC cord-010092-uftc8inx 4951 9 asked ask VBN cord-010092-uftc8inx 4951 10 about about IN cord-010092-uftc8inx 4951 11 the the DT cord-010092-uftc8inx 4951 12 languages language NNS cord-010092-uftc8inx 4951 13 which which WDT cord-010092-uftc8inx 4951 14 they -PRON- PRP cord-010092-uftc8inx 4951 15 can can MD cord-010092-uftc8inx 4951 16 read read VB cord-010092-uftc8inx 4951 17 and and CC cord-010092-uftc8inx 4951 18 understand understand VB cord-010092-uftc8inx 4951 19 and and CC cord-010092-uftc8inx 4951 20 1860 1860 CD cord-010092-uftc8inx 4951 21 responses response NNS cord-010092-uftc8inx 4951 22 were be VBD cord-010092-uftc8inx 4951 23 obtained obtain VBN cord-010092-uftc8inx 4951 24 . . . cord-010092-uftc8inx 4952 1 The the DT cord-010092-uftc8inx 4952 2 most most RBS cord-010092-uftc8inx 4952 3 common common JJ cord-010092-uftc8inx 4952 4 languages language NNS cord-010092-uftc8inx 4952 5 which which WDT cord-010092-uftc8inx 4952 6 can can MD cord-010092-uftc8inx 4952 7 be be VB cord-010092-uftc8inx 4952 8 read read VBN cord-010092-uftc8inx 4952 9 and and CC cord-010092-uftc8inx 4952 10 understood understand VBN cord-010092-uftc8inx 4952 11 by by IN cord-010092-uftc8inx 4952 12 blood blood NN cord-010092-uftc8inx 4952 13 donors donor NNS cord-010092-uftc8inx 4952 14 in in IN cord-010092-uftc8inx 4952 15 DBDC DBDC NNP cord-010092-uftc8inx 4952 16 are be VBP cord-010092-uftc8inx 4952 17 English English NNP cord-010092-uftc8inx 4952 18 ( ( -LRB- cord-010092-uftc8inx 4952 19 N n NN cord-010092-uftc8inx 4952 20 = = SYM cord-010092-uftc8inx 4952 21 760 760 CD cord-010092-uftc8inx 4952 22 ; ; : cord-010092-uftc8inx 4952 23 41 41 CD cord-010092-uftc8inx 4952 24 % % NN cord-010092-uftc8inx 4952 25 ) ) -RRB- cord-010092-uftc8inx 4952 26 , , , cord-010092-uftc8inx 4952 27 Arabic arabic JJ cord-010092-uftc8inx 4952 28 ( ( -LRB- cord-010092-uftc8inx 4952 29 N n NN cord-010092-uftc8inx 4952 30 = = SYM cord-010092-uftc8inx 4952 31 272 272 CD cord-010092-uftc8inx 4952 32 ; ; : cord-010092-uftc8inx 4952 33 14.6 14.6 CD cord-010092-uftc8inx 4952 34 % % NN cord-010092-uftc8inx 4952 35 ) ) -RRB- cord-010092-uftc8inx 4952 36 , , , cord-010092-uftc8inx 4952 37 Hindi Hindi NNP cord-010092-uftc8inx 4952 38 ( ( -LRB- cord-010092-uftc8inx 4952 39 N n NN cord-010092-uftc8inx 4952 40 = = SYM cord-010092-uftc8inx 4952 41 268 268 CD cord-010092-uftc8inx 4952 42 ; ; : cord-010092-uftc8inx 4952 43 14.4 14.4 CD cord-010092-uftc8inx 4952 44 % % NN cord-010092-uftc8inx 4952 45 ) ) -RRB- cord-010092-uftc8inx 4952 46 and and CC cord-010092-uftc8inx 4952 47 Malayalam Malayalam NNP cord-010092-uftc8inx 4952 48 ( ( -LRB- cord-010092-uftc8inx 4952 49 N n NN cord-010092-uftc8inx 4952 50 = = SYM cord-010092-uftc8inx 4952 51 233 233 CD cord-010092-uftc8inx 4952 52 ; ; : cord-010092-uftc8inx 4952 53 12.3 12.3 CD cord-010092-uftc8inx 4952 54 % % NN cord-010092-uftc8inx 4952 55 ) ) -RRB- cord-010092-uftc8inx 4952 56 . . . cord-010092-uftc8inx 4953 1 The the DT cord-010092-uftc8inx 4953 2 donors donor NNS cord-010092-uftc8inx 4953 3 come come VBP cord-010092-uftc8inx 4953 4 from from IN cord-010092-uftc8inx 4953 5 different different JJ cord-010092-uftc8inx 4953 6 countries country NNS cord-010092-uftc8inx 4953 7 , , , cord-010092-uftc8inx 4953 8 most most RBS cord-010092-uftc8inx 4953 9 common common JJ cord-010092-uftc8inx 4953 10 591 591 CD cord-010092-uftc8inx 4953 11 ( ( -LRB- cord-010092-uftc8inx 4953 12 54.7 54.7 CD cord-010092-uftc8inx 4953 13 % % NN cord-010092-uftc8inx 4953 14 ) ) -RRB- cord-010092-uftc8inx 4954 1 donors donor NNS cord-010092-uftc8inx 4954 2 are be VBP cord-010092-uftc8inx 4954 3 Indian indian JJ cord-010092-uftc8inx 4954 4 and and CC cord-010092-uftc8inx 4954 5 73 73 CD cord-010092-uftc8inx 4954 6 ( ( -LRB- cord-010092-uftc8inx 4954 7 6.8 6.8 CD cord-010092-uftc8inx 4954 8 % % NN cord-010092-uftc8inx 4954 9 ) ) -RRB- cord-010092-uftc8inx 4954 10 are be VBP cord-010092-uftc8inx 4954 11 from from IN cord-010092-uftc8inx 4954 12 UAE UAE NNP cord-010092-uftc8inx 4954 13 . . . cord-010092-uftc8inx 4955 1 It -PRON- PRP cord-010092-uftc8inx 4955 2 was be VBD cord-010092-uftc8inx 4955 3 found find VBN cord-010092-uftc8inx 4955 4 that that IN cord-010092-uftc8inx 4955 5 45 45 CD cord-010092-uftc8inx 4955 6 % % NN cord-010092-uftc8inx 4955 7 donors donor NNS cord-010092-uftc8inx 4955 8 can can MD cord-010092-uftc8inx 4955 9 read read VB cord-010092-uftc8inx 4955 10 and and CC cord-010092-uftc8inx 4955 11 understand understand VB cord-010092-uftc8inx 4955 12 only only RB cord-010092-uftc8inx 4955 13 one one CD cord-010092-uftc8inx 4955 14 language language NN cord-010092-uftc8inx 4955 15 . . . cord-010092-uftc8inx 4956 1 Majority majority NN cord-010092-uftc8inx 4956 2 884 884 CD cord-010092-uftc8inx 4956 3 ( ( -LRB- cord-010092-uftc8inx 4956 4 81.9 81.9 CD cord-010092-uftc8inx 4956 5 % % NN cord-010092-uftc8inx 4956 6 ) ) -RRB- cord-010092-uftc8inx 4957 1 donors donor NNS cord-010092-uftc8inx 4957 2 can can MD cord-010092-uftc8inx 4957 3 read read VB cord-010092-uftc8inx 4957 4 and and CC cord-010092-uftc8inx 4957 5 understand understand VB cord-010092-uftc8inx 4957 6 either either DT cord-010092-uftc8inx 4957 7 of of IN cord-010092-uftc8inx 4957 8 the the DT cord-010092-uftc8inx 4957 9 official official JJ cord-010092-uftc8inx 4957 10 languages language NNS cord-010092-uftc8inx 4957 11 Arabic arabic JJ cord-010092-uftc8inx 4957 12 or or CC cord-010092-uftc8inx 4957 13 English English NNP cord-010092-uftc8inx 4957 14 . . . cord-010092-uftc8inx 4958 1 However however RB cord-010092-uftc8inx 4958 2 , , , cord-010092-uftc8inx 4958 3 196 196 CD cord-010092-uftc8inx 4958 4 ( ( -LRB- cord-010092-uftc8inx 4958 5 18.1 18.1 CD cord-010092-uftc8inx 4958 6 % % NN cord-010092-uftc8inx 4958 7 ) ) -RRB- cord-010092-uftc8inx 4958 8 donors donor NNS cord-010092-uftc8inx 4958 9 ca can MD cord-010092-uftc8inx 4958 10 n't not RB cord-010092-uftc8inx 4958 11 read read VB cord-010092-uftc8inx 4958 12 and and CC cord-010092-uftc8inx 4958 13 understand understand VB cord-010092-uftc8inx 4958 14 these these DT cord-010092-uftc8inx 4958 15 two two CD cord-010092-uftc8inx 4958 16 official official JJ cord-010092-uftc8inx 4958 17 languages language NNS cord-010092-uftc8inx 4958 18 , , , cord-010092-uftc8inx 4958 19 the the DT cord-010092-uftc8inx 4958 20 other other JJ cord-010092-uftc8inx 4958 21 common common JJ cord-010092-uftc8inx 4958 22 languages language NNS cord-010092-uftc8inx 4958 23 being be VBG cord-010092-uftc8inx 4958 24 Hindi Hindi NNP cord-010092-uftc8inx 4958 25 and and CC cord-010092-uftc8inx 4958 26 Malayalam Malayalam NNP cord-010092-uftc8inx 4958 27 . . . cord-010092-uftc8inx 4959 1 The the DT cord-010092-uftc8inx 4959 2 donors donor NNS cord-010092-uftc8inx 4959 3 were be VBD cord-010092-uftc8inx 4959 4 asked ask VBN cord-010092-uftc8inx 4959 5 about about IN cord-010092-uftc8inx 4959 6 the the DT cord-010092-uftc8inx 4959 7 preferred preferred JJ cord-010092-uftc8inx 4959 8 mode mode NN cord-010092-uftc8inx 4959 9 of of IN cord-010092-uftc8inx 4959 10 communication communication NN cord-010092-uftc8inx 4959 11 , , , cord-010092-uftc8inx 4959 12 1290 1290 CD cord-010092-uftc8inx 4959 13 responses response NNS cord-010092-uftc8inx 4959 14 were be VBD cord-010092-uftc8inx 4959 15 obtained obtain VBN cord-010092-uftc8inx 4959 16 . . . cord-010092-uftc8inx 4960 1 The the DT cord-010092-uftc8inx 4960 2 most most RBS cord-010092-uftc8inx 4960 3 common common JJ cord-010092-uftc8inx 4960 4 mode mode NN cord-010092-uftc8inx 4960 5 of of IN cord-010092-uftc8inx 4960 6 communication communication NN cord-010092-uftc8inx 4960 7 were be VBD cord-010092-uftc8inx 4960 8 SMS SMS NNP cord-010092-uftc8inx 4960 9 and and CC cord-010092-uftc8inx 4960 10 Telephone Telephone NNP cord-010092-uftc8inx 4960 11 ( ( -LRB- cord-010092-uftc8inx 4960 12 85 85 CD cord-010092-uftc8inx 4960 13 % % NN cord-010092-uftc8inx 4960 14 together together RB cord-010092-uftc8inx 4960 15 ) ) -RRB- cord-010092-uftc8inx 4960 16 . . . cord-010092-uftc8inx 4961 1 Summary Summary NNP cord-010092-uftc8inx 4961 2 / / SYM cord-010092-uftc8inx 4961 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 4961 4 : : : cord-010092-uftc8inx 4962 1 Based base VBN cord-010092-uftc8inx 4962 2 on on IN cord-010092-uftc8inx 4962 3 the the DT cord-010092-uftc8inx 4962 4 above above JJ cord-010092-uftc8inx 4962 5 findings finding NNS cord-010092-uftc8inx 4962 6 , , , cord-010092-uftc8inx 4962 7 it -PRON- PRP cord-010092-uftc8inx 4962 8 can can MD cord-010092-uftc8inx 4962 9 be be VB cord-010092-uftc8inx 4962 10 concluded conclude VBN cord-010092-uftc8inx 4962 11 that that IN cord-010092-uftc8inx 4962 12 the the DT cord-010092-uftc8inx 4962 13 blood blood NN cord-010092-uftc8inx 4962 14 donor donor NN cord-010092-uftc8inx 4962 15 profile profile NN cord-010092-uftc8inx 4962 16 in in IN cord-010092-uftc8inx 4962 17 our -PRON- PRP$ cord-010092-uftc8inx 4962 18 centre centre NN cord-010092-uftc8inx 4962 19 is be VBZ cord-010092-uftc8inx 4962 20 multinational multinational JJ cord-010092-uftc8inx 4962 21 which which WDT cord-010092-uftc8inx 4962 22 is be VBZ cord-010092-uftc8inx 4962 23 a a DT cord-010092-uftc8inx 4962 24 unique unique JJ cord-010092-uftc8inx 4962 25 and and CC cord-010092-uftc8inx 4962 26 almost almost RB cord-010092-uftc8inx 4962 27 similar similar JJ cord-010092-uftc8inx 4962 28 to to IN cord-010092-uftc8inx 4962 29 the the DT cord-010092-uftc8inx 4962 30 population population NN cord-010092-uftc8inx 4962 31 profile profile NN cord-010092-uftc8inx 4962 32 of of IN cord-010092-uftc8inx 4962 33 Dubai Dubai NNP cord-010092-uftc8inx 4962 34 . . . cord-010092-uftc8inx 4963 1 As as IN cord-010092-uftc8inx 4963 2 18.1 18.1 CD cord-010092-uftc8inx 4963 3 % % NN cord-010092-uftc8inx 4963 4 donors donor NNS cord-010092-uftc8inx 4963 5 ca can MD cord-010092-uftc8inx 4963 6 n't not RB cord-010092-uftc8inx 4963 7 read read VB cord-010092-uftc8inx 4963 8 and and CC cord-010092-uftc8inx 4963 9 understand understand VB cord-010092-uftc8inx 4963 10 Arabic arabic JJ cord-010092-uftc8inx 4963 11 and and CC cord-010092-uftc8inx 4963 12 English English NNP cord-010092-uftc8inx 4963 13 , , , cord-010092-uftc8inx 4963 14 so so CC cord-010092-uftc8inx 4963 15 it -PRON- PRP cord-010092-uftc8inx 4963 16 has have VBZ cord-010092-uftc8inx 4963 17 been be VBN cord-010092-uftc8inx 4963 18 decided decide VBN cord-010092-uftc8inx 4963 19 that that IN cord-010092-uftc8inx 4963 20 the the DT cord-010092-uftc8inx 4963 21 educational educational JJ cord-010092-uftc8inx 4963 22 material material NN cord-010092-uftc8inx 4963 23 and and CC cord-010092-uftc8inx 4963 24 questionnaire questionnaire NN cord-010092-uftc8inx 4963 25 need need VB cord-010092-uftc8inx 4963 26 to to TO cord-010092-uftc8inx 4963 27 be be VB cord-010092-uftc8inx 4963 28 prepared prepare VBN cord-010092-uftc8inx 4963 29 in in IN cord-010092-uftc8inx 4963 30 one one CD cord-010092-uftc8inx 4963 31 more more JJR cord-010092-uftc8inx 4963 32 language language NN cord-010092-uftc8inx 4963 33 . . . cord-010092-uftc8inx 4964 1 Hindi Hindi NNP cord-010092-uftc8inx 4964 2 has have VBZ cord-010092-uftc8inx 4964 3 been be VBN cord-010092-uftc8inx 4964 4 decided decide VBN cord-010092-uftc8inx 4964 5 as as IN cord-010092-uftc8inx 4964 6 the the DT cord-010092-uftc8inx 4964 7 third third JJ cord-010092-uftc8inx 4964 8 language language NN cord-010092-uftc8inx 4964 9 in in IN cord-010092-uftc8inx 4964 10 the the DT cord-010092-uftc8inx 4964 11 centre centre NN cord-010092-uftc8inx 4964 12 and and CC cord-010092-uftc8inx 4964 13 donor donor NN cord-010092-uftc8inx 4964 14 questionnaire questionnaire NN cord-010092-uftc8inx 4964 15 and and CC cord-010092-uftc8inx 4964 16 educational educational JJ cord-010092-uftc8inx 4964 17 materials material NNS cord-010092-uftc8inx 4964 18 in in IN cord-010092-uftc8inx 4964 19 Hindi Hindi NNP cord-010092-uftc8inx 4964 20 will will MD cord-010092-uftc8inx 4964 21 also also RB cord-010092-uftc8inx 4964 22 be be VB cord-010092-uftc8inx 4964 23 made make VBN cord-010092-uftc8inx 4964 24 available available JJ cord-010092-uftc8inx 4964 25 to to IN cord-010092-uftc8inx 4964 26 the the DT cord-010092-uftc8inx 4964 27 donors donor NNS cord-010092-uftc8inx 4964 28 . . . cord-010092-uftc8inx 4965 1 Further further RB cord-010092-uftc8inx 4965 2 , , , cord-010092-uftc8inx 4965 3 the the DT cord-010092-uftc8inx 4965 4 donors donor NNS cord-010092-uftc8inx 4965 5 will will MD cord-010092-uftc8inx 4965 6 be be VB cord-010092-uftc8inx 4965 7 communicated communicate VBN cord-010092-uftc8inx 4965 8 through through IN cord-010092-uftc8inx 4965 9 SMS sms NN cord-010092-uftc8inx 4965 10 for for IN cord-010092-uftc8inx 4965 11 routine routine JJ cord-010092-uftc8inx 4965 12 messaging messaging NN cord-010092-uftc8inx 4965 13 and and CC cord-010092-uftc8inx 4965 14 disease disease NN cord-010092-uftc8inx 4965 15 notification notification NN cord-010092-uftc8inx 4965 16 while while IN cord-010092-uftc8inx 4965 17 telephonic telephonic JJ cord-010092-uftc8inx 4965 18 calls call NNS cord-010092-uftc8inx 4965 19 will will MD cord-010092-uftc8inx 4965 20 be be VB cord-010092-uftc8inx 4965 21 done do VBN cord-010092-uftc8inx 4965 22 only only RB cord-010092-uftc8inx 4965 23 when when WRB cord-010092-uftc8inx 4965 24 the the DT cord-010092-uftc8inx 4965 25 blood blood NN cord-010092-uftc8inx 4965 26 is be VBZ cord-010092-uftc8inx 4965 27 urgently urgently RB cord-010092-uftc8inx 4965 28 required require VBN cord-010092-uftc8inx 4965 29 . . . cord-010092-uftc8inx 4966 1 Background background NN cord-010092-uftc8inx 4966 2 : : : cord-010092-uftc8inx 4967 1 Metabolic metabolic JJ cord-010092-uftc8inx 4967 2 disorders disorder NNS cord-010092-uftc8inx 4967 3 ( ( -LRB- cord-010092-uftc8inx 4967 4 MetDs MetDs NNP cord-010092-uftc8inx 4967 5 ) ) -RRB- cord-010092-uftc8inx 4967 6 , , , cord-010092-uftc8inx 4967 7 including include VBG cord-010092-uftc8inx 4967 8 hypertension hypertension NN cord-010092-uftc8inx 4967 9 , , , cord-010092-uftc8inx 4967 10 dyslipidemia dyslipidemia NN cord-010092-uftc8inx 4967 11 , , , cord-010092-uftc8inx 4967 12 hyperglycemia hyperglycemia NN cord-010092-uftc8inx 4967 13 , , , cord-010092-uftc8inx 4967 14 and and CC cord-010092-uftc8inx 4967 15 central central JJ cord-010092-uftc8inx 4967 16 obesity obesity NN cord-010092-uftc8inx 4967 17 , , , cord-010092-uftc8inx 4967 18 are be VBP cord-010092-uftc8inx 4967 19 tightly tightly RB cord-010092-uftc8inx 4967 20 associated associate VBN cord-010092-uftc8inx 4967 21 with with IN cord-010092-uftc8inx 4967 22 cardiovascular cardiovascular JJ cord-010092-uftc8inx 4967 23 diseases disease NNS cord-010092-uftc8inx 4967 24 and and CC cord-010092-uftc8inx 4967 25 type type NN cord-010092-uftc8inx 4967 26 2 2 CD cord-010092-uftc8inx 4967 27 diabetes diabetes NN cord-010092-uftc8inx 4967 28 mellitus mellitus NN cord-010092-uftc8inx 4967 29 . . . cord-010092-uftc8inx 4968 1 Due due IN cord-010092-uftc8inx 4968 2 to to IN cord-010092-uftc8inx 4968 3 the the DT cord-010092-uftc8inx 4968 4 sedentary sedentary JJ cord-010092-uftc8inx 4968 5 lifestyle lifestyle NN cord-010092-uftc8inx 4968 6 and and CC cord-010092-uftc8inx 4968 7 increased increase VBN cord-010092-uftc8inx 4968 8 consumption consumption NN cord-010092-uftc8inx 4968 9 of of IN cord-010092-uftc8inx 4968 10 high high JJ cord-010092-uftc8inx 4968 11 - - HYPH cord-010092-uftc8inx 4968 12 calorie calorie NN cord-010092-uftc8inx 4968 13 diet diet NN cord-010092-uftc8inx 4968 14 in in IN cord-010092-uftc8inx 4968 15 modern modern JJ cord-010092-uftc8inx 4968 16 society society NN cord-010092-uftc8inx 4968 17 , , , cord-010092-uftc8inx 4968 18 MetDs MetDs NNP cord-010092-uftc8inx 4968 19 have have VBP cord-010092-uftc8inx 4968 20 become become VBN cord-010092-uftc8inx 4968 21 serious serious JJ cord-010092-uftc8inx 4968 22 health health NN cord-010092-uftc8inx 4968 23 problems problem NNS cord-010092-uftc8inx 4968 24 worldwide worldwide RB cord-010092-uftc8inx 4968 25 . . . cord-010092-uftc8inx 4969 1 To to TO cord-010092-uftc8inx 4969 2 have have VB cord-010092-uftc8inx 4969 3 a a DT cord-010092-uftc8inx 4969 4 better well JJR cord-010092-uftc8inx 4969 5 understanding understanding NN cord-010092-uftc8inx 4969 6 and and CC cord-010092-uftc8inx 4969 7 possible possible JJ cord-010092-uftc8inx 4969 8 improvement improvement NN cord-010092-uftc8inx 4969 9 on on IN cord-010092-uftc8inx 4969 10 blood blood NN cord-010092-uftc8inx 4969 11 donors donor NNS cord-010092-uftc8inx 4969 12 ' ' POS cord-010092-uftc8inx 4969 13 health health NN cord-010092-uftc8inx 4969 14 condition condition NN cord-010092-uftc8inx 4969 15 , , , cord-010092-uftc8inx 4969 16 we -PRON- PRP cord-010092-uftc8inx 4969 17 conducted conduct VBD cord-010092-uftc8inx 4969 18 a a DT cord-010092-uftc8inx 4969 19 survey survey NN cord-010092-uftc8inx 4969 20 of of IN cord-010092-uftc8inx 4969 21 the the DT cord-010092-uftc8inx 4969 22 prevalence prevalence NN cord-010092-uftc8inx 4969 23 of of IN cord-010092-uftc8inx 4969 24 MetDs metds NN cord-010092-uftc8inx 4969 25 among among IN cord-010092-uftc8inx 4969 26 blood blood NN cord-010092-uftc8inx 4969 27 donors donor NNS cord-010092-uftc8inx 4969 28 in in IN cord-010092-uftc8inx 4969 29 a a DT cord-010092-uftc8inx 4969 30 blood blood NN cord-010092-uftc8inx 4969 31 donation donation NN cord-010092-uftc8inx 4969 32 station station NN cord-010092-uftc8inx 4969 33 located locate VBN cord-010092-uftc8inx 4969 34 in in IN cord-010092-uftc8inx 4969 35 the the DT cord-010092-uftc8inx 4969 36 Hsinchu Hsinchu NNP cord-010092-uftc8inx 4969 37 Science Science NNP cord-010092-uftc8inx 4969 38 Park Park NNP cord-010092-uftc8inx 4969 39 in in IN cord-010092-uftc8inx 4969 40 Taiwan Taiwan NNP cord-010092-uftc8inx 4969 41 . . . cord-010092-uftc8inx 4970 1 Participants participant NNS cord-010092-uftc8inx 4970 2 with with IN cord-010092-uftc8inx 4970 3 MetDs MetDs NNP cord-010092-uftc8inx 4970 4 will will MD cord-010092-uftc8inx 4970 5 be be VB cord-010092-uftc8inx 4970 6 provided provide VBN cord-010092-uftc8inx 4970 7 with with IN cord-010092-uftc8inx 4970 8 health health NN cord-010092-uftc8inx 4970 9 education education NN cord-010092-uftc8inx 4970 10 materials material NNS cord-010092-uftc8inx 4970 11 about about IN cord-010092-uftc8inx 4970 12 metabolic metabolic JJ cord-010092-uftc8inx 4970 13 risk risk NN cord-010092-uftc8inx 4970 14 reduction reduction NN cord-010092-uftc8inx 4970 15 , , , cord-010092-uftc8inx 4970 16 in in IN cord-010092-uftc8inx 4970 17 order order NN cord-010092-uftc8inx 4970 18 to to TO cord-010092-uftc8inx 4970 19 prevent prevent VB cord-010092-uftc8inx 4970 20 the the DT cord-010092-uftc8inx 4970 21 development development NN cord-010092-uftc8inx 4970 22 of of IN cord-010092-uftc8inx 4970 23 future future JJ cord-010092-uftc8inx 4970 24 complications complication NNS cord-010092-uftc8inx 4970 25 . . . cord-010092-uftc8inx 4971 1 Aims aim VBZ cord-010092-uftc8inx 4971 2 : : : cord-010092-uftc8inx 4972 1 The the DT cord-010092-uftc8inx 4972 2 aims aim NNS cord-010092-uftc8inx 4972 3 of of IN cord-010092-uftc8inx 4972 4 this this DT cord-010092-uftc8inx 4972 5 study study NN cord-010092-uftc8inx 4972 6 were be VBD cord-010092-uftc8inx 4972 7 to to TO cord-010092-uftc8inx 4972 8 determine determine VB cord-010092-uftc8inx 4972 9 the the DT cord-010092-uftc8inx 4972 10 prevalence prevalence NN cord-010092-uftc8inx 4972 11 of of IN cord-010092-uftc8inx 4972 12 metabolic metabolic JJ cord-010092-uftc8inx 4972 13 disorders disorder NNS cord-010092-uftc8inx 4972 14 among among IN cord-010092-uftc8inx 4972 15 blood blood NN cord-010092-uftc8inx 4972 16 donors donor NNS cord-010092-uftc8inx 4972 17 , , , cord-010092-uftc8inx 4972 18 and and CC cord-010092-uftc8inx 4972 19 to to TO cord-010092-uftc8inx 4972 20 calculate calculate VB cord-010092-uftc8inx 4972 21 how how WRB cord-010092-uftc8inx 4972 22 much much JJ cord-010092-uftc8inx 4972 23 money money NN cord-010092-uftc8inx 4972 24 would would MD cord-010092-uftc8inx 4972 25 be be VB cord-010092-uftc8inx 4972 26 paid pay VBN cord-010092-uftc8inx 4972 27 to to TO cord-010092-uftc8inx 4972 28 identify identify VB cord-010092-uftc8inx 4972 29 a a DT cord-010092-uftc8inx 4972 30 case case NN cord-010092-uftc8inx 4972 31 of of IN cord-010092-uftc8inx 4972 32 hyperglycemia hyperglycemia NN cord-010092-uftc8inx 4972 33 , , , cord-010092-uftc8inx 4972 34 hyperlipidemia hyperlipidemia NN cord-010092-uftc8inx 4972 35 , , , cord-010092-uftc8inx 4972 36 or or CC cord-010092-uftc8inx 4972 37 undiagnosed undiagnosed JJ cord-010092-uftc8inx 4972 38 diabetes diabetes NN cord-010092-uftc8inx 4972 39 . . . cord-010092-uftc8inx 4973 1 Methods method NNS cord-010092-uftc8inx 4973 2 : : : cord-010092-uftc8inx 4973 3 This this DT cord-010092-uftc8inx 4973 4 study study NN cord-010092-uftc8inx 4973 5 was be VBD cord-010092-uftc8inx 4973 6 approved approve VBN cord-010092-uftc8inx 4973 7 by by IN cord-010092-uftc8inx 4973 8 the the DT cord-010092-uftc8inx 4973 9 institutional institutional NNP cord-010092-uftc8inx 4973 10 review review NNP cord-010092-uftc8inx 4973 11 board board NN cord-010092-uftc8inx 4973 12 of of IN cord-010092-uftc8inx 4973 13 Taiwan Taiwan NNP cord-010092-uftc8inx 4973 14 Blood Blood NNP cord-010092-uftc8inx 4973 15 Services Services NNP cord-010092-uftc8inx 4973 16 Foundation Foundation NNP cord-010092-uftc8inx 4973 17 ( ( -LRB- cord-010092-uftc8inx 4973 18 TBSF TBSF NNP cord-010092-uftc8inx 4973 19 ) ) -RRB- cord-010092-uftc8inx 4973 20 . . . cord-010092-uftc8inx 4974 1 The the DT cord-010092-uftc8inx 4974 2 body body NN cord-010092-uftc8inx 4974 3 weight weight NN cord-010092-uftc8inx 4974 4 , , , cord-010092-uftc8inx 4974 5 body body NN cord-010092-uftc8inx 4974 6 height height NN cord-010092-uftc8inx 4974 7 , , , cord-010092-uftc8inx 4974 8 waist waist NN cord-010092-uftc8inx 4974 9 circumference circumference NN cord-010092-uftc8inx 4974 10 ( ( -LRB- cord-010092-uftc8inx 4974 11 WC WC NNP cord-010092-uftc8inx 4974 12 ) ) -RRB- cord-010092-uftc8inx 4974 13 and and CC cord-010092-uftc8inx 4974 14 blood blood NN cord-010092-uftc8inx 4974 15 pressure pressure NN cord-010092-uftc8inx 4974 16 ( ( -LRB- cord-010092-uftc8inx 4974 17 BP BP NNP cord-010092-uftc8inx 4974 18 ) ) -RRB- cord-010092-uftc8inx 4974 19 of of IN cord-010092-uftc8inx 4974 20 participants participant NNS cord-010092-uftc8inx 4974 21 were be VBD cord-010092-uftc8inx 4974 22 measured measure VBN cord-010092-uftc8inx 4974 23 . . . cord-010092-uftc8inx 4975 1 Blood blood NN cord-010092-uftc8inx 4975 2 samples sample NNS cord-010092-uftc8inx 4975 3 were be VBD cord-010092-uftc8inx 4975 4 obtained obtain VBN cord-010092-uftc8inx 4975 5 to to TO cord-010092-uftc8inx 4975 6 determine determine VB cord-010092-uftc8inx 4975 7 the the DT cord-010092-uftc8inx 4975 8 values value NNS cord-010092-uftc8inx 4975 9 of of IN cord-010092-uftc8inx 4975 10 hemoglobin hemoglobin NN cord-010092-uftc8inx 4975 11 A1c A1c NNP cord-010092-uftc8inx 4975 12 ( ( -LRB- cord-010092-uftc8inx 4975 13 HbA1c HbA1c NNP cord-010092-uftc8inx 4975 14 ) ) -RRB- cord-010092-uftc8inx 4975 15 Background background NN cord-010092-uftc8inx 4975 16 : : : cord-010092-uftc8inx 4976 1 The the DT cord-010092-uftc8inx 4976 2 law law NN cord-010092-uftc8inx 4976 3 on on IN cord-010092-uftc8inx 4976 4 blood blood NN cord-010092-uftc8inx 4976 5 donation donation NN cord-010092-uftc8inx 4976 6 supports support VBZ cord-010092-uftc8inx 4976 7 the the DT cord-010092-uftc8inx 4976 8 development development NN cord-010092-uftc8inx 4976 9 of of IN cord-010092-uftc8inx 4976 10 the the DT cord-010092-uftc8inx 4976 11 blood blood NN cord-010092-uftc8inx 4976 12 service service NN cord-010092-uftc8inx 4976 13 and and CC cord-010092-uftc8inx 4976 14 guarantees guarantee VBZ cord-010092-uftc8inx 4976 15 the the DT cord-010092-uftc8inx 4976 16 protection protection NN cord-010092-uftc8inx 4976 17 of of IN cord-010092-uftc8inx 4976 18 the the DT cord-010092-uftc8inx 4976 19 donor donor NN cord-010092-uftc8inx 4976 20 's 's POS cord-010092-uftc8inx 4976 21 rights right NNS cord-010092-uftc8inx 4976 22 and and CC cord-010092-uftc8inx 4976 23 the the DT cord-010092-uftc8inx 4976 24 maintenance maintenance NN cord-010092-uftc8inx 4976 25 of of IN cord-010092-uftc8inx 4976 26 health health NN cord-010092-uftc8inx 4976 27 during during IN cord-010092-uftc8inx 4976 28 blood blood NN cord-010092-uftc8inx 4976 29 donation donation NN cord-010092-uftc8inx 4976 30 in in IN cord-010092-uftc8inx 4976 31 the the DT cord-010092-uftc8inx 4976 32 Russian Russian NNP cord-010092-uftc8inx 4976 33 Federation Federation NNP cord-010092-uftc8inx 4976 34 . . . cord-010092-uftc8inx 4977 1 National national JJ cord-010092-uftc8inx 4977 2 criteria criterion NNS cord-010092-uftc8inx 4977 3 for for IN cord-010092-uftc8inx 4977 4 donor donor NN cord-010092-uftc8inx 4977 5 selection selection NN cord-010092-uftc8inx 4977 6 for for IN cord-010092-uftc8inx 4977 7 blood blood NN cord-010092-uftc8inx 4977 8 donation donation NN cord-010092-uftc8inx 4977 9 are be VBP cord-010092-uftc8inx 4977 10 used use VBN cord-010092-uftc8inx 4977 11 in in IN cord-010092-uftc8inx 4977 12 the the DT cord-010092-uftc8inx 4977 13 activities activity NNS cord-010092-uftc8inx 4977 14 of of IN cord-010092-uftc8inx 4977 15 blood blood NN cord-010092-uftc8inx 4977 16 service service NN cord-010092-uftc8inx 4977 17 establishments establishment NNS cord-010092-uftc8inx 4977 18 and and CC cord-010092-uftc8inx 4977 19 are be VBP cord-010092-uftc8inx 4977 20 aimed aim VBN cord-010092-uftc8inx 4977 21 at at IN cord-010092-uftc8inx 4977 22 ensuring ensure VBG cord-010092-uftc8inx 4977 23 the the DT cord-010092-uftc8inx 4977 24 blood blood NN cord-010092-uftc8inx 4977 25 products product NNS cord-010092-uftc8inx 4977 26 safety safety NN cord-010092-uftc8inx 4977 27 . . . cord-010092-uftc8inx 4978 1 The the DT cord-010092-uftc8inx 4978 2 study study NN cord-010092-uftc8inx 4978 3 of of IN cord-010092-uftc8inx 4978 4 the the DT cord-010092-uftc8inx 4978 5 characteristics characteristic NNS cord-010092-uftc8inx 4978 6 of of IN cord-010092-uftc8inx 4978 7 blood blood NN cord-010092-uftc8inx 4978 8 donors donor NNS cord-010092-uftc8inx 4978 9 allows allow VBZ cord-010092-uftc8inx 4978 10 to to TO cord-010092-uftc8inx 4978 11 predict predict VB cord-010092-uftc8inx 4978 12 the the DT cord-010092-uftc8inx 4978 13 development development NN cord-010092-uftc8inx 4978 14 of of IN cord-010092-uftc8inx 4978 15 blood blood NN cord-010092-uftc8inx 4978 16 service service NN cord-010092-uftc8inx 4978 17 and and CC cord-010092-uftc8inx 4978 18 to to TO cord-010092-uftc8inx 4978 19 plan plan VB cord-010092-uftc8inx 4978 20 the the DT cord-010092-uftc8inx 4978 21 volume volume NN cord-010092-uftc8inx 4978 22 of of IN cord-010092-uftc8inx 4978 23 blood blood NN cord-010092-uftc8inx 4978 24 products product NNS cord-010092-uftc8inx 4978 25 for for IN cord-010092-uftc8inx 4978 26 transfusion transfusion NN cord-010092-uftc8inx 4978 27 and and CC cord-010092-uftc8inx 4978 28 plasma plasma NN cord-010092-uftc8inx 4978 29 fractionation fractionation NN cord-010092-uftc8inx 4978 30 . . . cord-010092-uftc8inx 4979 1 Aims aim VBZ cord-010092-uftc8inx 4979 2 : : : cord-010092-uftc8inx 4980 1 The the DT cord-010092-uftc8inx 4980 2 aim aim NN cord-010092-uftc8inx 4980 3 of of IN cord-010092-uftc8inx 4980 4 this this DT cord-010092-uftc8inx 4980 5 work work NN cord-010092-uftc8inx 4980 6 was be VBD cord-010092-uftc8inx 4980 7 to to TO cord-010092-uftc8inx 4980 8 study study VB cord-010092-uftc8inx 4980 9 the the DT cord-010092-uftc8inx 4980 10 characteristics characteristic NNS cord-010092-uftc8inx 4980 11 of of IN cord-010092-uftc8inx 4980 12 whole whole JJ cord-010092-uftc8inx 4980 13 blood blood NN cord-010092-uftc8inx 4980 14 and and CC cord-010092-uftc8inx 4980 15 apheresis apheresis NN cord-010092-uftc8inx 4980 16 donors donor NNS cord-010092-uftc8inx 4980 17 in in IN cord-010092-uftc8inx 4980 18 the the DT cord-010092-uftc8inx 4980 19 blood blood NN cord-010092-uftc8inx 4980 20 service service NN cord-010092-uftc8inx 4980 21 in in IN cord-010092-uftc8inx 4980 22 the the DT cord-010092-uftc8inx 4980 23 Russian Russian NNP cord-010092-uftc8inx 4980 24 Federation Federation NNP cord-010092-uftc8inx 4980 25 . . . cord-010092-uftc8inx 4981 1 Methods method NNS cord-010092-uftc8inx 4981 2 : : : cord-010092-uftc8inx 4981 3 Indicators indicator NNS cord-010092-uftc8inx 4981 4 of of IN cord-010092-uftc8inx 4981 5 activity activity NN cord-010092-uftc8inx 4981 6 in in IN cord-010092-uftc8inx 4981 7 the the DT cord-010092-uftc8inx 4981 8 blood blood NN cord-010092-uftc8inx 4981 9 service service NN cord-010092-uftc8inx 4981 10 establishments establishment NNS cord-010092-uftc8inx 4981 11 in in IN cord-010092-uftc8inx 4981 12 the the DT cord-010092-uftc8inx 4981 13 Russian Russian NNP cord-010092-uftc8inx 4981 14 Federation Federation NNP cord-010092-uftc8inx 4981 15 in in IN cord-010092-uftc8inx 4981 16 sectoral sectoral JJ cord-010092-uftc8inx 4981 17 statistical statistical JJ cord-010092-uftc8inx 4981 18 observations observation NNS cord-010092-uftc8inx 4981 19 over over IN cord-010092-uftc8inx 4981 20 the the DT cord-010092-uftc8inx 4981 21 period period NN cord-010092-uftc8inx 4981 22 2015 2015 CD cord-010092-uftc8inx 4981 23 - - SYM cord-010092-uftc8inx 4981 24 2017 2017 CD cord-010092-uftc8inx 4981 25 and and CC cord-010092-uftc8inx 4981 26 the the DT cord-010092-uftc8inx 4981 27 calculation calculation NN cord-010092-uftc8inx 4981 28 of of IN cord-010092-uftc8inx 4981 29 indices index NNS cord-010092-uftc8inx 4981 30 characterizing characterize VBG cord-010092-uftc8inx 4981 31 the the DT cord-010092-uftc8inx 4981 32 whole whole JJ cord-010092-uftc8inx 4981 33 blood blood NN cord-010092-uftc8inx 4981 34 and and CC cord-010092-uftc8inx 4981 35 apheresis apheresis NN cord-010092-uftc8inx 4981 36 donors donor NNS cord-010092-uftc8inx 4981 37 were be VBD cord-010092-uftc8inx 4981 38 analyzed analyze VBN cord-010092-uftc8inx 4981 39 . . . cord-010092-uftc8inx 4982 1 Data datum NNS cord-010092-uftc8inx 4982 2 are be VBP cord-010092-uftc8inx 4982 3 presented present VBN cord-010092-uftc8inx 4982 4 according accord VBG cord-010092-uftc8inx 4982 5 to to IN cord-010092-uftc8inx 4982 6 the the DT cord-010092-uftc8inx 4982 7 administrative administrative JJ cord-010092-uftc8inx 4982 8 division division NN cord-010092-uftc8inx 4982 9 of of IN cord-010092-uftc8inx 4982 10 Russian Russian NNP cord-010092-uftc8inx 4982 11 Federation Federation NNP cord-010092-uftc8inx 4982 12 into into IN cord-010092-uftc8inx 4982 13 federal federal JJ cord-010092-uftc8inx 4982 14 districts district NNS cord-010092-uftc8inx 4982 15 ( ( -LRB- cord-010092-uftc8inx 4982 16 FD FD NNP cord-010092-uftc8inx 4982 17 ) ) -RRB- cord-010092-uftc8inx 4982 18 . . . cord-010092-uftc8inx 4983 1 Results result NNS cord-010092-uftc8inx 4983 2 : : : cord-010092-uftc8inx 4984 1 The the DT cord-010092-uftc8inx 4984 2 proportion proportion NN cord-010092-uftc8inx 4984 3 of of IN cord-010092-uftc8inx 4984 4 whole whole JJ cord-010092-uftc8inx 4984 5 blood blood NN cord-010092-uftc8inx 4984 6 donors donor NNS cord-010092-uftc8inx 4984 7 was be VBD cord-010092-uftc8inx 4984 8 83.7 83.7 CD cord-010092-uftc8inx 4984 9 % % NN cord-010092-uftc8inx 4984 10 , , , cord-010092-uftc8inx 4984 11 plasmapheresis plasmapheresis NN cord-010092-uftc8inx 4984 12 donors donor NNS cord-010092-uftc8inx 4984 13 -13.2 -13.2 IN cord-010092-uftc8inx 4984 14 % % NN cord-010092-uftc8inx 4984 15 , , , cord-010092-uftc8inx 4984 16 blood blood NN cord-010092-uftc8inx 4984 17 cell cell NN cord-010092-uftc8inx 4984 18 apheresis apheresis NN cord-010092-uftc8inx 4984 19 , , , cord-010092-uftc8inx 4984 20 including include VBG cord-010092-uftc8inx 4984 21 plateletapheresis plateletapheresis NNP cord-010092-uftc8inx 4984 22 , , , cord-010092-uftc8inx 4984 23 donors donor NNS cord-010092-uftc8inx 4984 24 -3.1 -3.1 NNP cord-010092-uftc8inx 4984 25 % % NN cord-010092-uftc8inx 4984 26 . . . cord-010092-uftc8inx 4985 1 For for IN cord-010092-uftc8inx 4985 2 the the DT cord-010092-uftc8inx 4985 3 period period NN cord-010092-uftc8inx 4985 4 2015 2015 CD cord-010092-uftc8inx 4985 5 - - SYM cord-010092-uftc8inx 4985 6 2017 2017 CD cord-010092-uftc8inx 4985 7 , , , cord-010092-uftc8inx 4985 8 the the DT cord-010092-uftc8inx 4985 9 percentage percentage NN cord-010092-uftc8inx 4985 10 of of IN cord-010092-uftc8inx 4985 11 repeated repeat VBN cord-010092-uftc8inx 4985 12 and and CC cord-010092-uftc8inx 4985 13 regular regular JJ cord-010092-uftc8inx 4985 14 whole whole JJ cord-010092-uftc8inx 4985 15 blood blood NN cord-010092-uftc8inx 4985 16 and and CC cord-010092-uftc8inx 4985 17 apheresis apheresis NN cord-010092-uftc8inx 4985 18 donors donor NNS cord-010092-uftc8inx 4985 19 increased increase VBD cord-010092-uftc8inx 4985 20 from from IN cord-010092-uftc8inx 4985 21 66.2 66.2 CD cord-010092-uftc8inx 4985 22 % % NN cord-010092-uftc8inx 4985 23 to to IN cord-010092-uftc8inx 4985 24 72.2 72.2 CD cord-010092-uftc8inx 4985 25 % % NN cord-010092-uftc8inx 4985 26 . . . cord-010092-uftc8inx 4986 1 The the DT cord-010092-uftc8inx 4986 2 percentage percentage NN cord-010092-uftc8inx 4986 3 of of IN cord-010092-uftc8inx 4986 4 first first JJ cord-010092-uftc8inx 4986 5 - - HYPH cord-010092-uftc8inx 4986 6 time time NN cord-010092-uftc8inx 4986 7 donors donor NNS cord-010092-uftc8inx 4986 8 ranged range VBD cord-010092-uftc8inx 4986 9 from from IN cord-010092-uftc8inx 4986 10 27.8 27.8 CD cord-010092-uftc8inx 4986 11 % % NN cord-010092-uftc8inx 4986 12 to to IN cord-010092-uftc8inx 4986 13 33.8 33.8 CD cord-010092-uftc8inx 4986 14 % % NN cord-010092-uftc8inx 4986 15 . . . cord-010092-uftc8inx 4987 1 The the DT cord-010092-uftc8inx 4987 2 largest large JJS cord-010092-uftc8inx 4987 3 proportion proportion NN cord-010092-uftc8inx 4987 4 of of IN cord-010092-uftc8inx 4987 5 plasmapheresis plasmapheresis NN cord-010092-uftc8inx 4987 6 donors donor NNS cord-010092-uftc8inx 4987 7 was be VBD cord-010092-uftc8inx 4987 8 observed observe VBN cord-010092-uftc8inx 4987 9 in in IN cord-010092-uftc8inx 4987 10 the the DT cord-010092-uftc8inx 4987 11 Volga Volga NNP cord-010092-uftc8inx 4987 12 FD FD NNP cord-010092-uftc8inx 4987 13 ( ( -LRB- cord-010092-uftc8inx 4987 14 22.0 22.0 CD cord-010092-uftc8inx 4987 15 % % NN cord-010092-uftc8inx 4987 16 ) ) -RRB- cord-010092-uftc8inx 4987 17 . . . cord-010092-uftc8inx 4988 1 About about RB cord-010092-uftc8inx 4988 2 28.9 28.9 CD cord-010092-uftc8inx 4988 3 % % NN cord-010092-uftc8inx 4988 4 of of IN cord-010092-uftc8inx 4988 5 the the DT cord-010092-uftc8inx 4988 6 total total JJ cord-010092-uftc8inx 4988 7 plasma plasma NN cord-010092-uftc8inx 4988 8 was be VBD cord-010092-uftc8inx 4988 9 collected collect VBN cord-010092-uftc8inx 4988 10 by by IN cord-010092-uftc8inx 4988 11 apheresis apheresis NN cord-010092-uftc8inx 4988 12 from from IN cord-010092-uftc8inx 4988 13 donors donor NNS cord-010092-uftc8inx 4988 14 . . . cord-010092-uftc8inx 4989 1 The the DT cord-010092-uftc8inx 4989 2 percentage percentage NN cord-010092-uftc8inx 4989 3 of of IN cord-010092-uftc8inx 4989 4 plateletapheresis plateletapheresis NN cord-010092-uftc8inx 4989 5 donors donor NNS cord-010092-uftc8inx 4989 6 increased increase VBD cord-010092-uftc8inx 4989 7 from from IN cord-010092-uftc8inx 4989 8 1.9 1.9 CD cord-010092-uftc8inx 4989 9 % % NN cord-010092-uftc8inx 4989 10 to to IN cord-010092-uftc8inx 4989 11 2.3 2.3 CD cord-010092-uftc8inx 4989 12 % % NN cord-010092-uftc8inx 4989 13 . . . cord-010092-uftc8inx 4990 1 The the DT cord-010092-uftc8inx 4990 2 largest large JJS cord-010092-uftc8inx 4990 3 percentage percentage NN cord-010092-uftc8inx 4990 4 of of IN cord-010092-uftc8inx 4990 5 plateletapheresis plateletapheresis NN cord-010092-uftc8inx 4990 6 donors donor NNS cord-010092-uftc8inx 4990 7 was be VBD cord-010092-uftc8inx 4990 8 observed observe VBN cord-010092-uftc8inx 4990 9 in in IN cord-010092-uftc8inx 4990 10 the the DT cord-010092-uftc8inx 4990 11 Central Central NNP cord-010092-uftc8inx 4990 12 FD FD NNP cord-010092-uftc8inx 4990 13 ( ( -LRB- cord-010092-uftc8inx 4990 14 2.9 2.9 CD cord-010092-uftc8inx 4990 15 % % NN cord-010092-uftc8inx 4990 16 ) ) -RRB- cord-010092-uftc8inx 4990 17 , , , cord-010092-uftc8inx 4990 18 where where WRB cord-010092-uftc8inx 4990 19 a a DT cord-010092-uftc8inx 4990 20 significant significant JJ cord-010092-uftc8inx 4990 21 part part NN cord-010092-uftc8inx 4990 22 of of IN cord-010092-uftc8inx 4990 23 medical medical JJ cord-010092-uftc8inx 4990 24 centers center NNS cord-010092-uftc8inx 4990 25 of of IN cord-010092-uftc8inx 4990 26 cardiac cardiac JJ cord-010092-uftc8inx 4990 27 surgery surgery NN cord-010092-uftc8inx 4990 28 , , , cord-010092-uftc8inx 4990 29 hematology hematology NN cord-010092-uftc8inx 4990 30 and and CC cord-010092-uftc8inx 4990 31 bone bone NN cord-010092-uftc8inx 4990 32 marrow marrow NN cord-010092-uftc8inx 4990 33 transplantation transplantation NN cord-010092-uftc8inx 4990 34 are be VBP cord-010092-uftc8inx 4990 35 located locate VBN cord-010092-uftc8inx 4990 36 . . . cord-010092-uftc8inx 4991 1 The the DT cord-010092-uftc8inx 4991 2 proportion proportion NN cord-010092-uftc8inx 4991 3 of of IN cord-010092-uftc8inx 4991 4 platelet platelet NN cord-010092-uftc8inx 4991 5 concentrate concentrate NN cord-010092-uftc8inx 4991 6 collected collect VBN cord-010092-uftc8inx 4991 7 by by IN cord-010092-uftc8inx 4991 8 apheresis apheresis NN cord-010092-uftc8inx 4991 9 increased increase VBD cord-010092-uftc8inx 4991 10 to to IN cord-010092-uftc8inx 4991 11 69.9 69.9 CD cord-010092-uftc8inx 4991 12 % % NN cord-010092-uftc8inx 4991 13 in in IN cord-010092-uftc8inx 4991 14 2017 2017 CD cord-010092-uftc8inx 4991 15 . . . cord-010092-uftc8inx 4992 1 Actions action NNS cord-010092-uftc8inx 4992 2 to to TO cord-010092-uftc8inx 4992 3 recruit recruit VB cord-010092-uftc8inx 4992 4 young young JJ cord-010092-uftc8inx 4992 5 donors donor NNS cord-010092-uftc8inx 4992 6 for for IN cord-010092-uftc8inx 4992 7 blood blood NN cord-010092-uftc8inx 4992 8 donation donation NN cord-010092-uftc8inx 4992 9 and and CC cord-010092-uftc8inx 4992 10 its -PRON- PRP$ cord-010092-uftc8inx 4992 11 components component NNS cord-010092-uftc8inx 4992 12 were be VBD cord-010092-uftc8inx 4992 13 regularly regularly RB cord-010092-uftc8inx 4992 14 carried carry VBN cord-010092-uftc8inx 4992 15 out out RP cord-010092-uftc8inx 4992 16 in in IN cord-010092-uftc8inx 4992 17 all all DT cord-010092-uftc8inx 4992 18 federal federal JJ cord-010092-uftc8inx 4992 19 districts district NNS cord-010092-uftc8inx 4992 20 . . . cord-010092-uftc8inx 4993 1 Summary Summary NNP cord-010092-uftc8inx 4993 2 / / SYM cord-010092-uftc8inx 4993 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 4993 4 : : : cord-010092-uftc8inx 4994 1 In in IN cord-010092-uftc8inx 4994 2 the the DT cord-010092-uftc8inx 4994 3 Russian Russian NNP cord-010092-uftc8inx 4994 4 Federation Federation NNP cord-010092-uftc8inx 4994 5 , , , cord-010092-uftc8inx 4994 6 the the DT cord-010092-uftc8inx 4994 7 structure structure NN cord-010092-uftc8inx 4994 8 of of IN cord-010092-uftc8inx 4994 9 donation donation NN cord-010092-uftc8inx 4994 10 is be VBZ cord-010092-uftc8inx 4994 11 characterized characterize VBN cord-010092-uftc8inx 4994 12 by by IN cord-010092-uftc8inx 4994 13 an an DT cord-010092-uftc8inx 4994 14 increase increase NN cord-010092-uftc8inx 4994 15 in in IN cord-010092-uftc8inx 4994 16 the the DT cord-010092-uftc8inx 4994 17 proportion proportion NN cord-010092-uftc8inx 4994 18 of of IN cord-010092-uftc8inx 4994 19 plateletapheresis plateletapheresis NN cord-010092-uftc8inx 4994 20 donors donor NNS cord-010092-uftc8inx 4994 21 , , , cord-010092-uftc8inx 4994 22 stabilization stabilization NN cord-010092-uftc8inx 4994 23 of of IN cord-010092-uftc8inx 4994 24 the the DT cord-010092-uftc8inx 4994 25 percentage percentage NN cord-010092-uftc8inx 4994 26 of of IN cord-010092-uftc8inx 4994 27 plasmapheresis plasmapheresis NN cord-010092-uftc8inx 4994 28 donors donor NNS cord-010092-uftc8inx 4994 29 and and CC cord-010092-uftc8inx 4994 30 an an DT cord-010092-uftc8inx 4994 31 increase increase NN cord-010092-uftc8inx 4994 32 in in IN cord-010092-uftc8inx 4994 33 the the DT cord-010092-uftc8inx 4994 34 proportion proportion NN cord-010092-uftc8inx 4994 35 of of IN cord-010092-uftc8inx 4994 36 repeated repeat VBN cord-010092-uftc8inx 4994 37 and and CC cord-010092-uftc8inx 4994 38 regular regular JJ cord-010092-uftc8inx 4994 39 whole whole JJ cord-010092-uftc8inx 4994 40 blood blood NN cord-010092-uftc8inx 4994 41 and and CC cord-010092-uftc8inx 4994 42 apheresis apheresis NN cord-010092-uftc8inx 4994 43 donors donor NNS cord-010092-uftc8inx 4994 44 . . . cord-010092-uftc8inx 4995 1 There there EX cord-010092-uftc8inx 4995 2 are be VBP cord-010092-uftc8inx 4995 3 significant significant JJ cord-010092-uftc8inx 4995 4 regional regional JJ cord-010092-uftc8inx 4995 5 variations variation NNS cord-010092-uftc8inx 4995 6 of of IN cord-010092-uftc8inx 4995 7 donor donor NN cord-010092-uftc8inx 4995 8 's 's POS cord-010092-uftc8inx 4995 9 characteristics characteristic NNS cord-010092-uftc8inx 4995 10 in in IN cord-010092-uftc8inx 4995 11 the the DT cord-010092-uftc8inx 4995 12 federal federal JJ cord-010092-uftc8inx 4995 13 districts district NNS cord-010092-uftc8inx 4995 14 . . . cord-010092-uftc8inx 4996 1 Background background NN cord-010092-uftc8inx 4996 2 : : : cord-010092-uftc8inx 4997 1 Shortage shortage NN cord-010092-uftc8inx 4997 2 of of IN cord-010092-uftc8inx 4997 3 blood blood NN cord-010092-uftc8inx 4997 4 supply supply NN cord-010092-uftc8inx 4997 5 despite despite IN cord-010092-uftc8inx 4997 6 continuous continuous JJ cord-010092-uftc8inx 4997 7 blood blood NN cord-010092-uftc8inx 4997 8 donation donation NN cord-010092-uftc8inx 4997 9 campaigns campaign NNS cord-010092-uftc8inx 4997 10 especially especially RB cord-010092-uftc8inx 4997 11 during during IN cord-010092-uftc8inx 4997 12 local local JJ cord-010092-uftc8inx 4997 13 festive festive JJ cord-010092-uftc8inx 4997 14 seasons season NNS cord-010092-uftc8inx 4997 15 has have VBZ cord-010092-uftc8inx 4997 16 been be VBN cord-010092-uftc8inx 4997 17 a a DT cord-010092-uftc8inx 4997 18 major major JJ cord-010092-uftc8inx 4997 19 issue issue NN cord-010092-uftc8inx 4997 20 in in IN cord-010092-uftc8inx 4997 21 our -PRON- PRP$ cord-010092-uftc8inx 4997 22 country country NN cord-010092-uftc8inx 4997 23 . . . cord-010092-uftc8inx 4998 1 Thus thus RB cord-010092-uftc8inx 4998 2 , , , cord-010092-uftc8inx 4998 3 our -PRON- PRP$ cord-010092-uftc8inx 4998 4 faculty faculty NN cord-010092-uftc8inx 4998 5 initiated initiate VBD cord-010092-uftc8inx 4998 6 blood blood NN cord-010092-uftc8inx 4998 7 donation donation NN cord-010092-uftc8inx 4998 8 drives drive VBZ cord-010092-uftc8inx 4998 9 in in IN cord-010092-uftc8inx 4998 10 collaboration collaboration NN cord-010092-uftc8inx 4998 11 with with IN cord-010092-uftc8inx 4998 12 National National NNP cord-010092-uftc8inx 4998 13 Blood Blood NNP cord-010092-uftc8inx 4998 14 Centre Centre NNP cord-010092-uftc8inx 4998 15 in in IN cord-010092-uftc8inx 4998 16 order order NN cord-010092-uftc8inx 4998 17 meet meet VB cord-010092-uftc8inx 4998 18 the the DT cord-010092-uftc8inx 4998 19 demand demand NN cord-010092-uftc8inx 4998 20 for for IN cord-010092-uftc8inx 4998 21 the the DT cord-010092-uftc8inx 4998 22 blood blood NN cord-010092-uftc8inx 4998 23 requirements requirement NNS cord-010092-uftc8inx 4998 24 . . . cord-010092-uftc8inx 4999 1 However however RB cord-010092-uftc8inx 4999 2 , , , cord-010092-uftc8inx 4999 3 the the DT cord-010092-uftc8inx 4999 4 pre pre JJ cord-010092-uftc8inx 4999 5 - - JJ cord-010092-uftc8inx 4999 6 donation donation NN cord-010092-uftc8inx 4999 7 deferral deferral NN cord-010092-uftc8inx 4999 8 rate rate NN cord-010092-uftc8inx 4999 9 was be VBD cord-010092-uftc8inx 4999 10 relatively relatively RB cord-010092-uftc8inx 4999 11 high high JJ cord-010092-uftc8inx 4999 12 among among IN cord-010092-uftc8inx 4999 13 our -PRON- PRP$ cord-010092-uftc8inx 4999 14 young young JJ cord-010092-uftc8inx 4999 15 blood blood NN cord-010092-uftc8inx 4999 16 donors donor NNS cord-010092-uftc8inx 4999 17 leading lead VBG cord-010092-uftc8inx 4999 18 to to IN cord-010092-uftc8inx 4999 19 loss loss NN cord-010092-uftc8inx 4999 20 of of IN cord-010092-uftc8inx 4999 21 valuable valuable JJ cord-010092-uftc8inx 4999 22 blood blood NN cord-010092-uftc8inx 4999 23 units unit NNS cord-010092-uftc8inx 4999 24 . . . cord-010092-uftc8inx 5000 1 Understanding understand VBG cord-010092-uftc8inx 5000 2 the the DT cord-010092-uftc8inx 5000 3 causes cause NNS cord-010092-uftc8inx 5000 4 of of IN cord-010092-uftc8inx 5000 5 donor donor NN cord-010092-uftc8inx 5000 6 deferral deferral NN cord-010092-uftc8inx 5000 7 provides provide VBZ cord-010092-uftc8inx 5000 8 direction direction NN cord-010092-uftc8inx 5000 9 on on IN cord-010092-uftc8inx 5000 10 strategies strategy NNS cord-010092-uftc8inx 5000 11 for for IN cord-010092-uftc8inx 5000 12 young young JJ cord-010092-uftc8inx 5000 13 donor donor NN cord-010092-uftc8inx 5000 14 recruitment recruitment NN cord-010092-uftc8inx 5000 15 and and CC cord-010092-uftc8inx 5000 16 retention retention NN cord-010092-uftc8inx 5000 17 of of IN cord-010092-uftc8inx 5000 18 future future JJ cord-010092-uftc8inx 5000 19 blood blood NN cord-010092-uftc8inx 5000 20 donation donation NN cord-010092-uftc8inx 5000 21 . . . cord-010092-uftc8inx 5001 1 Aims aim VBZ cord-010092-uftc8inx 5001 2 : : : cord-010092-uftc8inx 5002 1 The the DT cord-010092-uftc8inx 5002 2 aim aim NN cord-010092-uftc8inx 5002 3 of of IN cord-010092-uftc8inx 5002 4 this this DT cord-010092-uftc8inx 5002 5 study study NN cord-010092-uftc8inx 5002 6 is be VBZ cord-010092-uftc8inx 5002 7 to to TO cord-010092-uftc8inx 5002 8 evaluate evaluate VB cord-010092-uftc8inx 5002 9 the the DT cord-010092-uftc8inx 5002 10 young young JJ cord-010092-uftc8inx 5002 11 donor donor NN cord-010092-uftc8inx 5002 12 deferral deferral NN cord-010092-uftc8inx 5002 13 pattern pattern NN cord-010092-uftc8inx 5002 14 and and CC cord-010092-uftc8inx 5002 15 to to TO cord-010092-uftc8inx 5002 16 identify identify VB cord-010092-uftc8inx 5002 17 factors factor NNS cord-010092-uftc8inx 5002 18 which which WDT cord-010092-uftc8inx 5002 19 could could MD cord-010092-uftc8inx 5002 20 help help VB cord-010092-uftc8inx 5002 21 in in IN cord-010092-uftc8inx 5002 22 minimizing minimize VBG cord-010092-uftc8inx 5002 23 the the DT cord-010092-uftc8inx 5002 24 preventable preventable JJ cord-010092-uftc8inx 5002 25 deferrals deferral NNS cord-010092-uftc8inx 5002 26 . . . cord-010092-uftc8inx 5003 1 Methods method NNS cord-010092-uftc8inx 5003 2 : : : cord-010092-uftc8inx 5003 3 This this DT cord-010092-uftc8inx 5003 4 is be VBZ cord-010092-uftc8inx 5003 5 a a DT cord-010092-uftc8inx 5003 6 retrospective retrospective JJ cord-010092-uftc8inx 5003 7 study study NN cord-010092-uftc8inx 5003 8 of of IN cord-010092-uftc8inx 5003 9 voluntary voluntary JJ cord-010092-uftc8inx 5003 10 young young JJ cord-010092-uftc8inx 5003 11 blood blood NN cord-010092-uftc8inx 5003 12 donors donor NNS cord-010092-uftc8inx 5003 13 age age NN cord-010092-uftc8inx 5003 14 between between IN cord-010092-uftc8inx 5003 15 20 20 CD cord-010092-uftc8inx 5003 16 to to TO cord-010092-uftc8inx 5003 17 23 23 CD cord-010092-uftc8inx 5003 18 years year NNS cord-010092-uftc8inx 5003 19 old old JJ cord-010092-uftc8inx 5003 20 recruited recruit VBN cord-010092-uftc8inx 5003 21 during during IN cord-010092-uftc8inx 5003 22 mobile mobile JJ cord-010092-uftc8inx 5003 23 blood blood NN cord-010092-uftc8inx 5003 24 donation donation NN cord-010092-uftc8inx 5003 25 in in IN cord-010092-uftc8inx 5003 26 Faculty Faculty NNP cord-010092-uftc8inx 5003 27 of of IN cord-010092-uftc8inx 5003 28 Medicine Medicine NNP cord-010092-uftc8inx 5003 29 , , , cord-010092-uftc8inx 5003 30 Universiti Universiti NNP cord-010092-uftc8inx 5003 31 Teknologi Teknologi NNP cord-010092-uftc8inx 5003 32 MARA MARA NNP cord-010092-uftc8inx 5003 33 , , , cord-010092-uftc8inx 5003 34 Malaysia Malaysia NNP cord-010092-uftc8inx 5003 35 . . . cord-010092-uftc8inx 5004 1 The the DT cord-010092-uftc8inx 5004 2 study study NN cord-010092-uftc8inx 5004 3 was be VBD cord-010092-uftc8inx 5004 4 conducted conduct VBN cord-010092-uftc8inx 5004 5 between between IN cord-010092-uftc8inx 5004 6 January January NNP cord-010092-uftc8inx 5004 7 2016 2016 CD cord-010092-uftc8inx 5004 8 to to IN cord-010092-uftc8inx 5004 9 December December NNP cord-010092-uftc8inx 5004 10 2018 2018 CD cord-010092-uftc8inx 5004 11 . . . cord-010092-uftc8inx 5005 1 The the DT cord-010092-uftc8inx 5005 2 data datum NNS cord-010092-uftc8inx 5005 3 were be VBD cord-010092-uftc8inx 5005 4 retrieved retrieve VBN cord-010092-uftc8inx 5005 5 from from IN cord-010092-uftc8inx 5005 6 the the DT cord-010092-uftc8inx 5005 7 official official JJ cord-010092-uftc8inx 5005 8 reports report NNS cord-010092-uftc8inx 5005 9 of of IN cord-010092-uftc8inx 5005 10 each each DT cord-010092-uftc8inx 5005 11 mobile mobile JJ cord-010092-uftc8inx 5005 12 blood blood NN cord-010092-uftc8inx 5005 13 donation donation NN cord-010092-uftc8inx 5005 14 . . . cord-010092-uftc8inx 5006 1 Results result NNS cord-010092-uftc8inx 5006 2 : : : cord-010092-uftc8inx 5007 1 A a DT cord-010092-uftc8inx 5007 2 total total NN cord-010092-uftc8inx 5007 3 of of IN cord-010092-uftc8inx 5007 4 828 828 CD cord-010092-uftc8inx 5007 5 young young JJ cord-010092-uftc8inx 5007 6 blood blood NN cord-010092-uftc8inx 5007 7 donors donor NNS cord-010092-uftc8inx 5007 8 had have VBD cord-010092-uftc8inx 5007 9 attended attend VBN cord-010092-uftc8inx 5007 10 mobile mobile JJ cord-010092-uftc8inx 5007 11 blood blood NN cord-010092-uftc8inx 5007 12 donation donation NN cord-010092-uftc8inx 5007 13 during during IN cord-010092-uftc8inx 5007 14 the the DT cord-010092-uftc8inx 5007 15 study study NN cord-010092-uftc8inx 5007 16 period period NN cord-010092-uftc8inx 5007 17 . . . cord-010092-uftc8inx 5008 1 The the DT cord-010092-uftc8inx 5008 2 overall overall JJ cord-010092-uftc8inx 5008 3 pre pre JJ cord-010092-uftc8inx 5008 4 - - JJ cord-010092-uftc8inx 5008 5 donation donation NN cord-010092-uftc8inx 5008 6 deferral deferral NN cord-010092-uftc8inx 5008 7 rate rate NN cord-010092-uftc8inx 5008 8 is be VBZ cord-010092-uftc8inx 5008 9 25.6 25.6 CD cord-010092-uftc8inx 5008 10 % % NN cord-010092-uftc8inx 5008 11 . . . cord-010092-uftc8inx 5009 1 The the DT cord-010092-uftc8inx 5009 2 main main JJ cord-010092-uftc8inx 5009 3 causes cause NNS cord-010092-uftc8inx 5009 4 of of IN cord-010092-uftc8inx 5009 5 deferral deferral NN cord-010092-uftc8inx 5009 6 are be VBP cord-010092-uftc8inx 5009 7 low low JJ cord-010092-uftc8inx 5009 8 haemoglobin haemoglobin NN cord-010092-uftc8inx 5009 9 ( ( -LRB- cord-010092-uftc8inx 5009 10 Hb Hb NNP cord-010092-uftc8inx 5009 11 ) ) -RRB- cord-010092-uftc8inx 5009 12 level level NN cord-010092-uftc8inx 5009 13 ( ( -LRB- cord-010092-uftc8inx 5009 14 20.8 20.8 CD cord-010092-uftc8inx 5009 15 % % NN cord-010092-uftc8inx 5009 16 ) ) -RRB- cord-010092-uftc8inx 5009 17 followed follow VBN cord-010092-uftc8inx 5009 18 by by IN cord-010092-uftc8inx 5009 19 low low JJ cord-010092-uftc8inx 5009 20 blood blood NN cord-010092-uftc8inx 5009 21 pressure pressure NN cord-010092-uftc8inx 5009 22 ( ( -LRB- cord-010092-uftc8inx 5009 23 16.0 16.0 CD cord-010092-uftc8inx 5009 24 % % NN cord-010092-uftc8inx 5009 25 ) ) -RRB- cord-010092-uftc8inx 5009 26 , , , cord-010092-uftc8inx 5009 27 upper upper JJ cord-010092-uftc8inx 5009 28 respiratory respiratory JJ cord-010092-uftc8inx 5009 29 tract tract NN cord-010092-uftc8inx 5009 30 infection infection NN cord-010092-uftc8inx 5009 31 ( ( -LRB- cord-010092-uftc8inx 5009 32 11.3 11.3 CD cord-010092-uftc8inx 5009 33 % % NN cord-010092-uftc8inx 5009 34 ) ) -RRB- cord-010092-uftc8inx 5009 35 and and CC cord-010092-uftc8inx 5009 36 sleep sleep VB cord-010092-uftc8inx 5009 37 less less JJR cord-010092-uftc8inx 5009 38 than than IN cord-010092-uftc8inx 5009 39 5 5 CD cord-010092-uftc8inx 5009 40 h h NN cord-010092-uftc8inx 5009 41 ( ( -LRB- cord-010092-uftc8inx 5009 42 9.4 9.4 CD cord-010092-uftc8inx 5009 43 % % NN cord-010092-uftc8inx 5009 44 ) ) -RRB- cord-010092-uftc8inx 5009 45 . . . cord-010092-uftc8inx 5010 1 Summary Summary NNP cord-010092-uftc8inx 5010 2 / / SYM cord-010092-uftc8inx 5010 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 5010 4 : : : cord-010092-uftc8inx 5011 1 Low low JJ cord-010092-uftc8inx 5011 2 haemoglobin haemoglobin NN cord-010092-uftc8inx 5011 3 and and CC cord-010092-uftc8inx 5011 4 low low JJ cord-010092-uftc8inx 5011 5 blood blood NN cord-010092-uftc8inx 5011 6 pressure pressure NN cord-010092-uftc8inx 5011 7 are be VBP cord-010092-uftc8inx 5011 8 the the DT cord-010092-uftc8inx 5011 9 two two CD cord-010092-uftc8inx 5011 10 common common JJ cord-010092-uftc8inx 5011 11 reasons reason NNS cord-010092-uftc8inx 5011 12 for for IN cord-010092-uftc8inx 5011 13 blood blood NN cord-010092-uftc8inx 5011 14 donation donation NN cord-010092-uftc8inx 5011 15 deferral deferral NN cord-010092-uftc8inx 5011 16 among among IN cord-010092-uftc8inx 5011 17 our -PRON- PRP$ cord-010092-uftc8inx 5011 18 young young JJ cord-010092-uftc8inx 5011 19 blood blood NN cord-010092-uftc8inx 5011 20 donors donor NNS cord-010092-uftc8inx 5011 21 . . . cord-010092-uftc8inx 5012 1 In in IN cord-010092-uftc8inx 5012 2 our -PRON- PRP$ cord-010092-uftc8inx 5012 3 study study NN cord-010092-uftc8inx 5012 4 a a DT cord-010092-uftc8inx 5012 5 significant significant JJ cord-010092-uftc8inx 5012 6 proportion proportion NN cord-010092-uftc8inx 5012 7 of of IN cord-010092-uftc8inx 5012 8 deferrals deferral NNS cord-010092-uftc8inx 5012 9 are be VBP cord-010092-uftc8inx 5012 10 due due JJ cord-010092-uftc8inx 5012 11 to to TO cord-010092-uftc8inx 5012 12 sleep sleep VB cord-010092-uftc8inx 5012 13 less less JJR cord-010092-uftc8inx 5012 14 than than IN cord-010092-uftc8inx 5012 15 5 5 CD cord-010092-uftc8inx 5012 16 h h NN cord-010092-uftc8inx 5012 17 whereby whereby WRB cord-010092-uftc8inx 5012 18 this this DT cord-010092-uftc8inx 5012 19 could could MD cord-010092-uftc8inx 5012 20 be be VB cord-010092-uftc8inx 5012 21 prevented prevent VBN cord-010092-uftc8inx 5012 22 if if IN cord-010092-uftc8inx 5012 23 the the DT cord-010092-uftc8inx 5012 24 donors donor NNS cord-010092-uftc8inx 5012 25 are be VBP cord-010092-uftc8inx 5012 26 aware aware JJ cord-010092-uftc8inx 5012 27 of of IN cord-010092-uftc8inx 5012 28 the the DT cord-010092-uftc8inx 5012 29 donor donor NN cord-010092-uftc8inx 5012 30 selection selection NN cord-010092-uftc8inx 5012 31 criteria criterion NNS cord-010092-uftc8inx 5012 32 . . . cord-010092-uftc8inx 5013 1 Strategies strategy NNS cord-010092-uftc8inx 5013 2 to to TO cord-010092-uftc8inx 5013 3 mitigate mitigate VB cord-010092-uftc8inx 5013 4 preventable preventable JJ cord-010092-uftc8inx 5013 5 deferrals deferral NNS cord-010092-uftc8inx 5013 6 and and CC cord-010092-uftc8inx 5013 7 improve improve VB cord-010092-uftc8inx 5013 8 blood blood NN cord-010092-uftc8inx 5013 9 donor donor NN cord-010092-uftc8inx 5013 10 retention retention NN cord-010092-uftc8inx 5013 11 particularly particularly RB cord-010092-uftc8inx 5013 12 young young JJ cord-010092-uftc8inx 5013 13 blood blood NN cord-010092-uftc8inx 5013 14 donors donor NNS cord-010092-uftc8inx 5013 15 as as IN cord-010092-uftc8inx 5013 16 source source NN cord-010092-uftc8inx 5013 17 of of IN cord-010092-uftc8inx 5013 18 motivation motivation NN cord-010092-uftc8inx 5013 19 for for IN cord-010092-uftc8inx 5013 20 future future JJ cord-010092-uftc8inx 5013 21 blood blood NN cord-010092-uftc8inx 5013 22 donation donation NN cord-010092-uftc8inx 5013 23 are be VBP cord-010092-uftc8inx 5013 24 urged urge VBN cord-010092-uftc8inx 5013 25 to to TO cord-010092-uftc8inx 5013 26 avoid avoid VB cord-010092-uftc8inx 5013 27 additional additional JJ cord-010092-uftc8inx 5013 28 stress stress NN cord-010092-uftc8inx 5013 29 on on IN cord-010092-uftc8inx 5013 30 the the DT cord-010092-uftc8inx 5013 31 blood blood NN cord-010092-uftc8inx 5013 32 supply supply NN cord-010092-uftc8inx 5013 33 . . . cord-010092-uftc8inx 5014 1 Background background NN cord-010092-uftc8inx 5014 2 : : : cord-010092-uftc8inx 5015 1 In in IN cord-010092-uftc8inx 5015 2 the the DT cord-010092-uftc8inx 5015 3 modern modern JJ cord-010092-uftc8inx 5015 4 world world NN cord-010092-uftc8inx 5015 5 , , , cord-010092-uftc8inx 5015 6 donating donate VBG cord-010092-uftc8inx 5015 7 blood blood NN cord-010092-uftc8inx 5015 8 has have VBZ cord-010092-uftc8inx 5015 9 become become VBN cord-010092-uftc8inx 5015 10 a a DT cord-010092-uftc8inx 5015 11 humane humane JJ cord-010092-uftc8inx 5015 12 manner manner NN cord-010092-uftc8inx 5015 13 for for IN cord-010092-uftc8inx 5015 14 saving saving NN cord-010092-uftc8inx 5015 15 of of IN cord-010092-uftc8inx 5015 16 patients patient NNS cord-010092-uftc8inx 5015 17 life life NN cord-010092-uftc8inx 5015 18 . . . cord-010092-uftc8inx 5016 1 But but CC cord-010092-uftc8inx 5016 2 there there EX cord-010092-uftc8inx 5016 3 are be VBP cord-010092-uftc8inx 5016 4 barriers barrier NNS cord-010092-uftc8inx 5016 5 to to IN cord-010092-uftc8inx 5016 6 blood blood NN cord-010092-uftc8inx 5016 7 donation donation NN cord-010092-uftc8inx 5016 8 which which WDT cord-010092-uftc8inx 5016 9 are be VBP cord-010092-uftc8inx 5016 10 designed design VBN cord-010092-uftc8inx 5016 11 to to TO cord-010092-uftc8inx 5016 12 ensure ensure VB cord-010092-uftc8inx 5016 13 both both DT cord-010092-uftc8inx 5016 14 donor donor NN cord-010092-uftc8inx 5016 15 and and CC cord-010092-uftc8inx 5016 16 blood blood NN cord-010092-uftc8inx 5016 17 recipients recipient NNS cord-010092-uftc8inx 5016 18 ' ' POS cord-010092-uftc8inx 5016 19 safety safety NN cord-010092-uftc8inx 5016 20 . . . cord-010092-uftc8inx 5017 1 Anemia anemia NN cord-010092-uftc8inx 5017 2 is be VBZ cord-010092-uftc8inx 5017 3 one one CD cord-010092-uftc8inx 5017 4 of of IN cord-010092-uftc8inx 5017 5 the the DT cord-010092-uftc8inx 5017 6 most most RBS cord-010092-uftc8inx 5017 7 common common JJ cord-010092-uftc8inx 5017 8 health health NN cord-010092-uftc8inx 5017 9 problems problem NNS cord-010092-uftc8inx 5017 10 in in IN cord-010092-uftc8inx 5017 11 the the DT cord-010092-uftc8inx 5017 12 world world NN cord-010092-uftc8inx 5017 13 . . . cord-010092-uftc8inx 5018 1 Based base VBN cord-010092-uftc8inx 5018 2 on on IN cord-010092-uftc8inx 5018 3 the the DT cord-010092-uftc8inx 5018 4 WHO WHO NNP cord-010092-uftc8inx 5018 5 estimation estimation NN cord-010092-uftc8inx 5018 6 , , , cord-010092-uftc8inx 5018 7 nearly nearly RB cord-010092-uftc8inx 5018 8 a a DT cord-010092-uftc8inx 5018 9 quarter quarter NN cord-010092-uftc8inx 5018 10 of of IN cord-010092-uftc8inx 5018 11 the the DT cord-010092-uftc8inx 5018 12 world world NN cord-010092-uftc8inx 5018 13 's 's POS cord-010092-uftc8inx 5018 14 population population NN cord-010092-uftc8inx 5018 15 are be VBP cord-010092-uftc8inx 5018 16 suffering suffer VBG cord-010092-uftc8inx 5018 17 from from IN cord-010092-uftc8inx 5018 18 anemia anemia NN cord-010092-uftc8inx 5018 19 , , , cord-010092-uftc8inx 5018 20 its -PRON- PRP$ cord-010092-uftc8inx 5018 21 prevalence prevalence NN cord-010092-uftc8inx 5018 22 varies vary VBZ cord-010092-uftc8inx 5018 23 among among IN cord-010092-uftc8inx 5018 24 the the DT cord-010092-uftc8inx 5018 25 populations population NNS cord-010092-uftc8inx 5018 26 and and CC cord-010092-uftc8inx 5018 27 age age NN cord-010092-uftc8inx 5018 28 groups group NNS cord-010092-uftc8inx 5018 29 . . . cord-010092-uftc8inx 5019 1 The the DT cord-010092-uftc8inx 5019 2 prevalence prevalence NN cord-010092-uftc8inx 5019 3 of of IN cord-010092-uftc8inx 5019 4 anemia anemia NN cord-010092-uftc8inx 5019 5 among among IN cord-010092-uftc8inx 5019 6 men man NNS cord-010092-uftc8inx 5019 7 is be VBZ cord-010092-uftc8inx 5019 8 12.7 12.7 CD cord-010092-uftc8inx 5019 9 % % NN cord-010092-uftc8inx 5019 10 and and CC cord-010092-uftc8inx 5019 11 in in IN cord-010092-uftc8inx 5019 12 non non JJ cord-010092-uftc8inx 5019 13 - - JJ cord-010092-uftc8inx 5019 14 pregnant pregnant JJ cord-010092-uftc8inx 5019 15 women woman NNS cord-010092-uftc8inx 5019 16 is be VBZ cord-010092-uftc8inx 5019 17 30.2 30.2 CD cord-010092-uftc8inx 5019 18 % % NN cord-010092-uftc8inx 5019 19 . . . cord-010092-uftc8inx 5020 1 Aims aim VBZ cord-010092-uftc8inx 5020 2 : : : cord-010092-uftc8inx 5021 1 The the DT cord-010092-uftc8inx 5021 2 aim aim NN cord-010092-uftc8inx 5021 3 of of IN cord-010092-uftc8inx 5021 4 this this DT cord-010092-uftc8inx 5021 5 study study NN cord-010092-uftc8inx 5021 6 was be VBD cord-010092-uftc8inx 5021 7 to to TO cord-010092-uftc8inx 5021 8 determine determine VB cord-010092-uftc8inx 5021 9 the the DT cord-010092-uftc8inx 5021 10 status status NN cord-010092-uftc8inx 5021 11 of of IN cord-010092-uftc8inx 5021 12 hemoglobin hemoglobin NN cord-010092-uftc8inx 5021 13 in in IN cord-010092-uftc8inx 5021 14 volunteer volunteer NN cord-010092-uftc8inx 5021 15 blood blood NN cord-010092-uftc8inx 5021 16 donors donor NNS cord-010092-uftc8inx 5021 17 referring refer VBG cord-010092-uftc8inx 5021 18 to to IN cord-010092-uftc8inx 5021 19 Fars Fars NNP cord-010092-uftc8inx 5021 20 province province NN cord-010092-uftc8inx 5021 21 Blood Blood NNP cord-010092-uftc8inx 5021 22 Transfusion Transfusion NNP cord-010092-uftc8inx 5021 23 service service NN cord-010092-uftc8inx 5021 24 and and CC cord-010092-uftc8inx 5021 25 to to TO cord-010092-uftc8inx 5021 26 determine determine VB cord-010092-uftc8inx 5021 27 the the DT cord-010092-uftc8inx 5021 28 demographic demographic JJ cord-010092-uftc8inx 5021 29 status status NN cord-010092-uftc8inx 5021 30 of of IN cord-010092-uftc8inx 5021 31 them -PRON- PRP cord-010092-uftc8inx 5021 32 during during IN cord-010092-uftc8inx 5021 33 the the DT cord-010092-uftc8inx 5021 34 last last JJ cord-010092-uftc8inx 5021 35 two two CD cord-010092-uftc8inx 5021 36 years year NNS cord-010092-uftc8inx 5021 37 . . . cord-010092-uftc8inx 5022 1 Our -PRON- PRP$ cord-010092-uftc8inx 5022 2 study study NN cord-010092-uftc8inx 5022 3 included include VBD cord-010092-uftc8inx 5022 4 blood blood NN cord-010092-uftc8inx 5022 5 donors donor NNS cord-010092-uftc8inx 5022 6 for for IN cord-010092-uftc8inx 5022 7 all all DT cord-010092-uftc8inx 5022 8 blood blood NN cord-010092-uftc8inx 5022 9 donors donor NNS cord-010092-uftc8inx 5022 10 during during IN cord-010092-uftc8inx 5022 11 the the DT cord-010092-uftc8inx 5022 12 last last JJ cord-010092-uftc8inx 5022 13 two two CD cord-010092-uftc8inx 5022 14 years year NNS cord-010092-uftc8inx 5022 15 . . . cord-010092-uftc8inx 5023 1 Methods method NNS cord-010092-uftc8inx 5023 2 : : : cord-010092-uftc8inx 5023 3 The the DT cord-010092-uftc8inx 5023 4 study study NN cord-010092-uftc8inx 5023 5 is be VBZ cord-010092-uftc8inx 5023 6 descriptive descriptive JJ cord-010092-uftc8inx 5023 7 cross cross JJ cord-010092-uftc8inx 5023 8 - - JJ cord-010092-uftc8inx 5023 9 sectional sectional JJ cord-010092-uftc8inx 5023 10 and and CC cord-010092-uftc8inx 5023 11 our -PRON- PRP$ cord-010092-uftc8inx 5023 12 sampling sampling NN cord-010092-uftc8inx 5023 13 was be VBD cord-010092-uftc8inx 5023 14 non non JJ cord-010092-uftc8inx 5023 15 - - JJ cord-010092-uftc8inx 5023 16 random random JJ cord-010092-uftc8inx 5023 17 and and CC cord-010092-uftc8inx 5023 18 simple simple JJ cord-010092-uftc8inx 5023 19 sampling sampling NN cord-010092-uftc8inx 5023 20 method method NN cord-010092-uftc8inx 5023 21 . . . cord-010092-uftc8inx 5024 1 All all DT cord-010092-uftc8inx 5024 2 parameters parameter NNS cord-010092-uftc8inx 5024 3 related relate VBN cord-010092-uftc8inx 5024 4 to to IN cord-010092-uftc8inx 5024 5 the the DT cord-010092-uftc8inx 5024 6 donors donor NNS cord-010092-uftc8inx 5024 7 , , , cord-010092-uftc8inx 5024 8 including include VBG cord-010092-uftc8inx 5024 9 age age NN cord-010092-uftc8inx 5024 10 , , , cord-010092-uftc8inx 5024 11 sex sex NN cord-010092-uftc8inx 5024 12 and and CC cord-010092-uftc8inx 5024 13 type type NN cord-010092-uftc8inx 5024 14 of of IN cord-010092-uftc8inx 5024 15 donation donation NN cord-010092-uftc8inx 5024 16 were be VBD cord-010092-uftc8inx 5024 17 investigated investigate VBN cord-010092-uftc8inx 5024 18 and and CC cord-010092-uftc8inx 5024 19 analyzed analyze VBN cord-010092-uftc8inx 5024 20 in in IN cord-010092-uftc8inx 5024 21 SPSS SPSS NNP cord-010092-uftc8inx 5024 22 software software NN cord-010092-uftc8inx 5024 23 . . . cord-010092-uftc8inx 5025 1 Results result NNS cord-010092-uftc8inx 5025 2 : : : cord-010092-uftc8inx 5026 1 The the DT cord-010092-uftc8inx 5026 2 total total JJ cord-010092-uftc8inx 5026 3 number number NN cord-010092-uftc8inx 5026 4 of of IN cord-010092-uftc8inx 5026 5 referrals referral NNS cord-010092-uftc8inx 5026 6 for for IN cord-010092-uftc8inx 5026 7 blood blood NN cord-010092-uftc8inx 5026 8 donation donation NN cord-010092-uftc8inx 5026 9 was be VBD cord-010092-uftc8inx 5026 10 454913 454913 CD cord-010092-uftc8inx 5026 11 . . . cord-010092-uftc8inx 5027 1 Repeated repeat VBN cord-010092-uftc8inx 5027 2 blood blood NN cord-010092-uftc8inx 5027 3 donors donor NNS cord-010092-uftc8inx 5027 4 was be VBD cord-010092-uftc8inx 5027 5 44.8 44.8 CD cord-010092-uftc8inx 5027 6 % % NN cord-010092-uftc8inx 5027 7 of of IN cord-010092-uftc8inx 5027 8 total total JJ cord-010092-uftc8inx 5027 9 population population NN cord-010092-uftc8inx 5027 10 and and CC cord-010092-uftc8inx 5027 11 had have VBD cord-010092-uftc8inx 5027 12 the the DT cord-010092-uftc8inx 5027 13 highest high JJS cord-010092-uftc8inx 5027 14 number number NN cord-010092-uftc8inx 5027 15 of of IN cord-010092-uftc8inx 5027 16 referrals referral NNS cord-010092-uftc8inx 5027 17 , , , cord-010092-uftc8inx 5027 18 followed follow VBN cord-010092-uftc8inx 5027 19 by by IN cord-010092-uftc8inx 5027 20 first first JJ cord-010092-uftc8inx 5027 21 and and CC cord-010092-uftc8inx 5027 22 lapsed lapse VBN cord-010092-uftc8inx 5027 23 donors donor NNS cord-010092-uftc8inx 5027 24 with with IN cord-010092-uftc8inx 5027 25 31.2 31.2 CD cord-010092-uftc8inx 5027 26 % % NN cord-010092-uftc8inx 5027 27 and and CC cord-010092-uftc8inx 5027 28 24 24 CD cord-010092-uftc8inx 5027 29 % % NN cord-010092-uftc8inx 5027 30 respectively respectively RB cord-010092-uftc8inx 5027 31 . . . cord-010092-uftc8inx 5028 1 In in IN cord-010092-uftc8inx 5028 2 terms term NNS cord-010092-uftc8inx 5028 3 of of IN cord-010092-uftc8inx 5028 4 gender gender NN cord-010092-uftc8inx 5028 5 distribution distribution NN cord-010092-uftc8inx 5028 6 , , , cord-010092-uftc8inx 5028 7 6.2 6.2 CD cord-010092-uftc8inx 5028 8 % % NN cord-010092-uftc8inx 5028 9 were be VBD cord-010092-uftc8inx 5028 10 female female JJ cord-010092-uftc8inx 5028 11 and and CC cord-010092-uftc8inx 5028 12 93.8 93.8 CD cord-010092-uftc8inx 5028 13 % % NN cord-010092-uftc8inx 5028 14 were be VBD cord-010092-uftc8inx 5028 15 male male JJ cord-010092-uftc8inx 5028 16 . . . cord-010092-uftc8inx 5029 1 The the DT cord-010092-uftc8inx 5029 2 highest high JJS cord-010092-uftc8inx 5029 3 rate rate NN cord-010092-uftc8inx 5029 4 of of IN cord-010092-uftc8inx 5029 5 hemoglobin hemoglobin NN cord-010092-uftc8inx 5029 6 level level NN cord-010092-uftc8inx 5030 1 less less JJR cord-010092-uftc8inx 5030 2 than than IN cord-010092-uftc8inx 5030 3 12.5 12.5 CD cord-010092-uftc8inx 5030 4 g g NN cord-010092-uftc8inx 5030 5 / / SYM cord-010092-uftc8inx 5030 6 dl dl NNP cord-010092-uftc8inx 5030 7 was be VBD cord-010092-uftc8inx 5030 8 found find VBN cord-010092-uftc8inx 5030 9 in in IN cord-010092-uftc8inx 5030 10 first first JJ cord-010092-uftc8inx 5030 11 - - HYPH cord-010092-uftc8inx 5030 12 time time NN cord-010092-uftc8inx 5030 13 donors donor NNS cord-010092-uftc8inx 5030 14 with with IN cord-010092-uftc8inx 5030 15 51.6 51.6 CD cord-010092-uftc8inx 5030 16 % % NN cord-010092-uftc8inx 5030 17 and and CC cord-010092-uftc8inx 5030 18 the the DT cord-010092-uftc8inx 5030 19 lowest low JJS cord-010092-uftc8inx 5030 20 prevalence prevalence NN cord-010092-uftc8inx 5030 21 was be VBD cord-010092-uftc8inx 5030 22 observed observe VBN cord-010092-uftc8inx 5030 23 in in IN cord-010092-uftc8inx 5030 24 lapsed lapsed JJ cord-010092-uftc8inx 5030 25 donors donor NNS cord-010092-uftc8inx 5030 26 , , , cord-010092-uftc8inx 5030 27 followed follow VBN cord-010092-uftc8inx 5030 28 by by IN cord-010092-uftc8inx 5030 29 repeated repeat VBN cord-010092-uftc8inx 5030 30 donors donor NNS cord-010092-uftc8inx 5030 31 with with IN cord-010092-uftc8inx 5030 32 24.7 24.7 CD cord-010092-uftc8inx 5030 33 % % NN cord-010092-uftc8inx 5030 34 . . . cord-010092-uftc8inx 5031 1 44.8 44.8 CD cord-010092-uftc8inx 5031 2 % % NN cord-010092-uftc8inx 5031 3 of of IN cord-010092-uftc8inx 5031 4 the the DT cord-010092-uftc8inx 5031 5 repeated repeat VBN cord-010092-uftc8inx 5031 6 blood blood NN cord-010092-uftc8inx 5031 7 donors donor NNS cord-010092-uftc8inx 5031 8 have have VBP cord-010092-uftc8inx 5031 9 hemoglobin hemoglobin NN cord-010092-uftc8inx 5031 10 higher high JJR cord-010092-uftc8inx 5031 11 than than IN cord-010092-uftc8inx 5031 12 16.5 16.5 CD cord-010092-uftc8inx 5031 13 . . . cord-010092-uftc8inx 5032 1 There there EX cord-010092-uftc8inx 5032 2 was be VBD cord-010092-uftc8inx 5032 3 a a DT cord-010092-uftc8inx 5032 4 significant significant JJ cord-010092-uftc8inx 5032 5 difference difference NN cord-010092-uftc8inx 5032 6 between between IN cord-010092-uftc8inx 5032 7 blood blood NN cord-010092-uftc8inx 5032 8 donation donation NN cord-010092-uftc8inx 5032 9 type type NN cord-010092-uftc8inx 5032 10 and and CC cord-010092-uftc8inx 5032 11 hemoglobin hemoglobin NN cord-010092-uftc8inx 5032 12 level level NN cord-010092-uftc8inx 5032 13 . . . cord-010092-uftc8inx 5033 1 Summary Summary NNP cord-010092-uftc8inx 5033 2 / / SYM cord-010092-uftc8inx 5033 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 5033 4 : : : cord-010092-uftc8inx 5034 1 According accord VBG cord-010092-uftc8inx 5034 2 to to IN cord-010092-uftc8inx 5034 3 our -PRON- PRP$ cord-010092-uftc8inx 5034 4 findings finding NNS cord-010092-uftc8inx 5034 5 , , , cord-010092-uftc8inx 5034 6 low low JJ cord-010092-uftc8inx 5034 7 hemoglobin hemoglobin NN cord-010092-uftc8inx 5034 8 levels level NNS cord-010092-uftc8inx 5034 9 are be VBP cord-010092-uftc8inx 5034 10 more more RBR cord-010092-uftc8inx 5034 11 common common JJ cord-010092-uftc8inx 5034 12 among among IN cord-010092-uftc8inx 5034 13 first first JJ cord-010092-uftc8inx 5034 14 - - HYPH cord-010092-uftc8inx 5034 15 time time NN cord-010092-uftc8inx 5034 16 and and CC cord-010092-uftc8inx 5034 17 female female JJ cord-010092-uftc8inx 5034 18 donors donor NNS cord-010092-uftc8inx 5034 19 , , , cord-010092-uftc8inx 5034 20 and and CC cord-010092-uftc8inx 5034 21 this this DT cord-010092-uftc8inx 5034 22 requires require VBZ cord-010092-uftc8inx 5034 23 a a DT cord-010092-uftc8inx 5034 24 special special JJ cord-010092-uftc8inx 5034 25 training training NN cord-010092-uftc8inx 5034 26 among among IN cord-010092-uftc8inx 5034 27 these these DT cord-010092-uftc8inx 5034 28 groups group NNS cord-010092-uftc8inx 5034 29 . . . cord-010092-uftc8inx 5035 1 Because because IN cord-010092-uftc8inx 5035 2 the the DT cord-010092-uftc8inx 5035 3 high high JJ cord-010092-uftc8inx 5035 4 share share NN cord-010092-uftc8inx 5035 5 of of IN cord-010092-uftc8inx 5035 6 first first JJ cord-010092-uftc8inx 5035 7 time time NN cord-010092-uftc8inx 5035 8 donors donor NNS cord-010092-uftc8inx 5035 9 in in IN cord-010092-uftc8inx 5035 10 blood blood NN cord-010092-uftc8inx 5035 11 supply supply NN cord-010092-uftc8inx 5035 12 and and CC cord-010092-uftc8inx 5035 13 the the DT cord-010092-uftc8inx 5035 14 positive positive JJ cord-010092-uftc8inx 5035 15 impact impact NN cord-010092-uftc8inx 5035 16 of of IN cord-010092-uftc8inx 5035 17 female female JJ cord-010092-uftc8inx 5035 18 donors donor NNS cord-010092-uftc8inx 5035 19 on on IN cord-010092-uftc8inx 5035 20 the the DT cord-010092-uftc8inx 5035 21 blood blood NN cord-010092-uftc8inx 5035 22 safety safety NN cord-010092-uftc8inx 5035 23 , , , cord-010092-uftc8inx 5035 24 corrective corrective JJ cord-010092-uftc8inx 5035 25 action action NN cord-010092-uftc8inx 5035 26 for for IN cord-010092-uftc8inx 5035 27 that that DT cord-010092-uftc8inx 5035 28 groups group NNS cord-010092-uftc8inx 5035 29 is be VBZ cord-010092-uftc8inx 5035 30 recommended recommend VBN cord-010092-uftc8inx 5035 31 . . . cord-010092-uftc8inx 5036 1 FINNISH finnish JJ cord-010092-uftc8inx 5036 2 BLOOD blood NN cord-010092-uftc8inx 5036 3 DONOR donor NN cord-010092-uftc8inx 5036 4 BIOBANK BIOBANK NNP cord-010092-uftc8inx 5036 5 J J NNP cord-010092-uftc8inx 5036 6 Partanen Partanen NNP cord-010092-uftc8inx 5036 7 , , , cord-010092-uftc8inx 5036 8 T T NNP cord-010092-uftc8inx 5036 9 Wahlfors Wahlfors NNP cord-010092-uftc8inx 5036 10 , , , cord-010092-uftc8inx 5036 11 M M NNP cord-010092-uftc8inx 5036 12 Arvas Arvas NNP cord-010092-uftc8inx 5036 13 , , , cord-010092-uftc8inx 5036 14 J J NNP cord-010092-uftc8inx 5036 15 Clancy Clancy NNP cord-010092-uftc8inx 5036 16 , , , cord-010092-uftc8inx 5036 17 K K NNP cord-010092-uftc8inx 5036 18 L€ L€ NNP cord-010092-uftc8inx 5036 19 ahteenm€ ahteenm€ . cord-010092-uftc8inx 5037 1 aki aki NNP cord-010092-uftc8inx 5037 2 , , , cord-010092-uftc8inx 5037 3 E E NNP cord-010092-uftc8inx 5037 4 Palokangas Palokangas NNP cord-010092-uftc8inx 5037 5 and and CC cord-010092-uftc8inx 5037 6 N n CD cord-010092-uftc8inx 5037 7 Nikiforow Nikiforow NNP cord-010092-uftc8inx 5037 8 Background Background NNP cord-010092-uftc8inx 5037 9 : : : cord-010092-uftc8inx 5038 1 The the DT cord-010092-uftc8inx 5038 2 increasing increase VBG cord-010092-uftc8inx 5038 3 need need NN cord-010092-uftc8inx 5038 4 for for IN cord-010092-uftc8inx 5038 5 large large JJ cord-010092-uftc8inx 5038 6 , , , cord-010092-uftc8inx 5038 7 well well RB cord-010092-uftc8inx 5038 8 - - HYPH cord-010092-uftc8inx 5038 9 characterized characterize VBN cord-010092-uftc8inx 5038 10 cohorts cohort NNS cord-010092-uftc8inx 5038 11 of of IN cord-010092-uftc8inx 5038 12 healthy healthy JJ cord-010092-uftc8inx 5038 13 individuals individual NNS cord-010092-uftc8inx 5038 14 for for IN cord-010092-uftc8inx 5038 15 modern modern JJ cord-010092-uftc8inx 5038 16 biomedical biomedical JJ cord-010092-uftc8inx 5038 17 research research NN cord-010092-uftc8inx 5038 18 , , , cord-010092-uftc8inx 5038 19 such such JJ cord-010092-uftc8inx 5038 20 as as IN cord-010092-uftc8inx 5038 21 genomics genomic NNS cord-010092-uftc8inx 5038 22 or or CC cord-010092-uftc8inx 5038 23 phenomics phenomic NNS cord-010092-uftc8inx 5038 24 studies study NNS cord-010092-uftc8inx 5038 25 typically typically RB cord-010092-uftc8inx 5038 26 including include VBG cord-010092-uftc8inx 5038 27 tens ten NNS cord-010092-uftc8inx 5038 28 or or CC cord-010092-uftc8inx 5038 29 even even RB cord-010092-uftc8inx 5038 30 hundreds hundred NNS cord-010092-uftc8inx 5038 31 of of IN cord-010092-uftc8inx 5038 32 thousands thousand NNS cord-010092-uftc8inx 5038 33 of of IN cord-010092-uftc8inx 5038 34 subjects subject NNS cord-010092-uftc8inx 5038 35 , , , cord-010092-uftc8inx 5038 36 has have VBZ cord-010092-uftc8inx 5038 37 posed pose VBN cord-010092-uftc8inx 5038 38 the the DT cord-010092-uftc8inx 5038 39 possibility possibility NN cord-010092-uftc8inx 5038 40 of of IN cord-010092-uftc8inx 5038 41 using use VBG cord-010092-uftc8inx 5038 42 blood blood NN cord-010092-uftc8inx 5038 43 services service NNS cord-010092-uftc8inx 5038 44 as as IN cord-010092-uftc8inx 5038 45 an an DT cord-010092-uftc8inx 5038 46 option option NN cord-010092-uftc8inx 5038 47 for for IN cord-010092-uftc8inx 5038 48 collecting collect VBG cord-010092-uftc8inx 5038 49 samples sample NNS cord-010092-uftc8inx 5038 50 and and CC cord-010092-uftc8inx 5038 51 related related JJ cord-010092-uftc8inx 5038 52 data datum NNS cord-010092-uftc8inx 5038 53 . . . cord-010092-uftc8inx 5039 1 The the DT cord-010092-uftc8inx 5039 2 possibility possibility NN cord-010092-uftc8inx 5039 3 to to TO cord-010092-uftc8inx 5039 4 re re VB cord-010092-uftc8inx 5039 5 - - VB cord-010092-uftc8inx 5039 6 contact contact JJ cord-010092-uftc8inx 5039 7 blood blood NN cord-010092-uftc8inx 5039 8 donors donor NNS cord-010092-uftc8inx 5039 9 for for IN cord-010092-uftc8inx 5039 10 repeated repeat VBN cord-010092-uftc8inx 5039 11 sampling sampling NN cord-010092-uftc8inx 5039 12 or or CC cord-010092-uftc8inx 5039 13 asking ask VBG cord-010092-uftc8inx 5039 14 for for IN cord-010092-uftc8inx 5039 15 additional additional JJ cord-010092-uftc8inx 5039 16 data datum NNS cord-010092-uftc8inx 5039 17 has have VBZ cord-010092-uftc8inx 5039 18 further further RB cord-010092-uftc8inx 5039 19 increased increase VBN cord-010092-uftc8inx 5039 20 interest interest NN cord-010092-uftc8inx 5039 21 in in IN cord-010092-uftc8inx 5039 22 collecting collect VBG cord-010092-uftc8inx 5039 23 large large JJ cord-010092-uftc8inx 5039 24 biobanks biobank NNS cord-010092-uftc8inx 5039 25 from from IN cord-010092-uftc8inx 5039 26 blood blood NN cord-010092-uftc8inx 5039 27 donors donor NNS cord-010092-uftc8inx 5039 28 . . . cord-010092-uftc8inx 5040 1 There there EX cord-010092-uftc8inx 5040 2 is be VBZ cord-010092-uftc8inx 5040 3 also also RB cord-010092-uftc8inx 5040 4 a a DT cord-010092-uftc8inx 5040 5 need need NN cord-010092-uftc8inx 5040 6 to to TO cord-010092-uftc8inx 5040 7 study study VB cord-010092-uftc8inx 5040 8 more more RBR cord-010092-uftc8inx 5040 9 thoroughly thoroughly RB cord-010092-uftc8inx 5040 10 the the DT cord-010092-uftc8inx 5040 11 effects effect NNS cord-010092-uftc8inx 5040 12 of of IN cord-010092-uftc8inx 5040 13 blood blood NN cord-010092-uftc8inx 5040 14 donation donation NN cord-010092-uftc8inx 5040 15 on on IN cord-010092-uftc8inx 5040 16 donor donor NN cord-010092-uftc8inx 5040 17 health health NN cord-010092-uftc8inx 5040 18 . . . cord-010092-uftc8inx 5041 1 Aims aim VBZ cord-010092-uftc8inx 5041 2 : : : cord-010092-uftc8inx 5042 1 The the DT cord-010092-uftc8inx 5042 2 first first JJ cord-010092-uftc8inx 5042 3 - - HYPH cord-010092-uftc8inx 5042 4 phase phase NN cord-010092-uftc8inx 5042 5 goal goal NN cord-010092-uftc8inx 5042 6 is be VBZ cord-010092-uftc8inx 5042 7 to to TO cord-010092-uftc8inx 5042 8 recruit recruit VB cord-010092-uftc8inx 5042 9 50,000 50,000 CD cord-010092-uftc8inx 5042 10 blood blood NN cord-010092-uftc8inx 5042 11 donors donor NNS cord-010092-uftc8inx 5042 12 with with IN cord-010092-uftc8inx 5042 13 broad broad JJ cord-010092-uftc8inx 5042 14 biobank biobank NNP cord-010092-uftc8inx 5042 15 consent consent NN cord-010092-uftc8inx 5042 16 for for IN cord-010092-uftc8inx 5042 17 the the DT cord-010092-uftc8inx 5042 18 FinnGen FinnGen NNP cord-010092-uftc8inx 5042 19 ( ( -LRB- cord-010092-uftc8inx 5042 20 https://www.finngen.fi/ https://www.finngen.fi/ NNP cord-010092-uftc8inx 5042 21 ) ) -RRB- cord-010092-uftc8inx 5042 22 project project NN cord-010092-uftc8inx 5042 23 , , , cord-010092-uftc8inx 5042 24 a a DT cord-010092-uftc8inx 5042 25 large large JJ cord-010092-uftc8inx 5042 26 publicprivate publicprivate NN cord-010092-uftc8inx 5042 27 effort effort NN cord-010092-uftc8inx 5042 28 aiming aim VBG cord-010092-uftc8inx 5042 29 to to TO cord-010092-uftc8inx 5042 30 collect collect VB cord-010092-uftc8inx 5042 31 genome genome NN cord-010092-uftc8inx 5042 32 and and CC cord-010092-uftc8inx 5042 33 health health NN cord-010092-uftc8inx 5042 34 - - HYPH cord-010092-uftc8inx 5042 35 related relate VBN cord-010092-uftc8inx 5042 36 registry registry NN cord-010092-uftc8inx 5042 37 data datum NNS cord-010092-uftc8inx 5042 38 of of IN cord-010092-uftc8inx 5042 39 10 10 CD cord-010092-uftc8inx 5042 40 % % NN cord-010092-uftc8inx 5042 41 ( ( -LRB- cord-010092-uftc8inx 5042 42 500,000 500,000 CD cord-010092-uftc8inx 5042 43 ) ) -RRB- cord-010092-uftc8inx 5042 44 of of IN cord-010092-uftc8inx 5042 45 the the DT cord-010092-uftc8inx 5042 46 Finnish finnish JJ cord-010092-uftc8inx 5042 47 population population NN cord-010092-uftc8inx 5042 48 . . . cord-010092-uftc8inx 5043 1 ( ( -LRB- cord-010092-uftc8inx 5043 2 11.58 11.58 CD cord-010092-uftc8inx 5043 3 % % NN cord-010092-uftc8inx 5043 4 ) ) -RRB- cord-010092-uftc8inx 5043 5 , , , cord-010092-uftc8inx 5043 6 dental dental JJ cord-010092-uftc8inx 5043 7 examination examination NN cord-010092-uftc8inx 5043 8 10(3.32 10(3.32 CD cord-010092-uftc8inx 5043 9 % % NN cord-010092-uftc8inx 5043 10 ) ) -RRB- cord-010092-uftc8inx 5043 11 and and CC cord-010092-uftc8inx 5043 12 medication medication NN cord-010092-uftc8inx 5043 13 history history NN cord-010092-uftc8inx 5043 14 6(1.98 6(1.98 CD cord-010092-uftc8inx 5043 15 % % NN cord-010092-uftc8inx 5043 16 ) ) -RRB- cord-010092-uftc8inx 5043 17 . . . cord-010092-uftc8inx 5044 1 Permanent permanent JJ cord-010092-uftc8inx 5044 2 deferral deferral NN cord-010092-uftc8inx 5044 3 namely namely RB cord-010092-uftc8inx 5044 4 , , , cord-010092-uftc8inx 5044 5 risk risk NN cord-010092-uftc8inx 5044 6 factor factor NN cord-010092-uftc8inx 5044 7 involving involve VBG cord-010092-uftc8inx 5044 8 transfusion transfusion NN cord-010092-uftc8inx 5044 9 transmitted transmit VBN cord-010092-uftc8inx 5044 10 infections infection NNS cord-010092-uftc8inx 5044 11 and and CC cord-010092-uftc8inx 5044 12 chronic chronic JJ cord-010092-uftc8inx 5044 13 disease disease NN cord-010092-uftc8inx 5044 14 were be VBD cord-010092-uftc8inx 5044 15 5(1.65 5(1.65 CD cord-010092-uftc8inx 5044 16 % % NN cord-010092-uftc8inx 5044 17 ) ) -RRB- cord-010092-uftc8inx 5044 18 and and CC cord-010092-uftc8inx 5044 19 8(2.64 8(2.64 CD cord-010092-uftc8inx 5044 20 % % NN cord-010092-uftc8inx 5044 21 ) ) -RRB- cord-010092-uftc8inx 5044 22 respectively respectively RB cord-010092-uftc8inx 5044 23 . . . cord-010092-uftc8inx 5045 1 The the DT cord-010092-uftc8inx 5045 2 prime prime JJ cord-010092-uftc8inx 5045 3 cause cause NN cord-010092-uftc8inx 5045 4 of of IN cord-010092-uftc8inx 5045 5 permanent permanent JJ cord-010092-uftc8inx 5045 6 deferral deferral NN cord-010092-uftc8inx 5045 7 was be VBD cord-010092-uftc8inx 5045 8 risk risk NN cord-010092-uftc8inx 5045 9 factor factor NN cord-010092-uftc8inx 5045 10 involving involve VBG cord-010092-uftc8inx 5045 11 transfusion transfusion NN cord-010092-uftc8inx 5045 12 transmitted transmit VBN cord-010092-uftc8inx 5045 13 infections infection NNS cord-010092-uftc8inx 5045 14 while while IN cord-010092-uftc8inx 5045 15 the the DT cord-010092-uftc8inx 5045 16 temporary temporary JJ cord-010092-uftc8inx 5045 17 deferral deferral NN cord-010092-uftc8inx 5045 18 was be VBD cord-010092-uftc8inx 5045 19 bed bed NN cord-010092-uftc8inx 5045 20 side side NN cord-010092-uftc8inx 5045 21 hypertension hypertension NN cord-010092-uftc8inx 5045 22 . . . cord-010092-uftc8inx 5046 1 Gender gender NN cord-010092-uftc8inx 5046 2 wise wise JJ cord-010092-uftc8inx 5046 3 , , , cord-010092-uftc8inx 5046 4 the the DT cord-010092-uftc8inx 5046 5 leading lead VBG cord-010092-uftc8inx 5046 6 cause cause NN cord-010092-uftc8inx 5046 7 of of IN cord-010092-uftc8inx 5046 8 donor donor NN cord-010092-uftc8inx 5046 9 deferral deferral NN cord-010092-uftc8inx 5046 10 in in IN cord-010092-uftc8inx 5046 11 male male NN cord-010092-uftc8inx 5046 12 was be VBD cord-010092-uftc8inx 5047 1 bed bed NN cord-010092-uftc8inx 5047 2 side side NN cord-010092-uftc8inx 5047 3 hypertension hypertension NN cord-010092-uftc8inx 5047 4 and and CC cord-010092-uftc8inx 5047 5 anaemia anaemia NN cord-010092-uftc8inx 5047 6 was be VBD cord-010092-uftc8inx 5047 7 the the DT cord-010092-uftc8inx 5047 8 major major JJ cord-010092-uftc8inx 5047 9 cause cause NN cord-010092-uftc8inx 5047 10 in in IN cord-010092-uftc8inx 5047 11 female female NN cord-010092-uftc8inx 5047 12 . . . cord-010092-uftc8inx 5048 1 Summary Summary NNP cord-010092-uftc8inx 5048 2 / / SYM cord-010092-uftc8inx 5048 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 5048 4 : : : cord-010092-uftc8inx 5049 1 The the DT cord-010092-uftc8inx 5049 2 findings finding NNS cord-010092-uftc8inx 5049 3 of of IN cord-010092-uftc8inx 5049 4 the the DT cord-010092-uftc8inx 5049 5 survey survey NN cord-010092-uftc8inx 5049 6 aid aid NN cord-010092-uftc8inx 5049 7 to to TO cord-010092-uftc8inx 5049 8 evaluate evaluate VB cord-010092-uftc8inx 5049 9 the the DT cord-010092-uftc8inx 5049 10 significant significant JJ cord-010092-uftc8inx 5049 11 causes cause NNS cord-010092-uftc8inx 5049 12 of of IN cord-010092-uftc8inx 5049 13 blood blood NN cord-010092-uftc8inx 5049 14 donor donor NN cord-010092-uftc8inx 5049 15 deferral deferral NN cord-010092-uftc8inx 5049 16 . . . cord-010092-uftc8inx 5050 1 This this DT cord-010092-uftc8inx 5050 2 study study NN cord-010092-uftc8inx 5050 3 suggests suggest VBZ cord-010092-uftc8inx 5050 4 that that IN cord-010092-uftc8inx 5050 5 the the DT cord-010092-uftc8inx 5050 6 restrictive restrictive JJ cord-010092-uftc8inx 5050 7 criteria criterion NNS cord-010092-uftc8inx 5050 8 can can MD cord-010092-uftc8inx 5050 9 be be VB cord-010092-uftc8inx 5050 10 used use VBN cord-010092-uftc8inx 5050 11 for for IN cord-010092-uftc8inx 5050 12 blood blood NN cord-010092-uftc8inx 5050 13 donor donor NN cord-010092-uftc8inx 5050 14 selection selection NN cord-010092-uftc8inx 5050 15 . . . cord-010092-uftc8inx 5051 1 This this DT cord-010092-uftc8inx 5051 2 will will MD cord-010092-uftc8inx 5051 3 in in IN cord-010092-uftc8inx 5051 4 turn turn NN cord-010092-uftc8inx 5051 5 increase increase VB cord-010092-uftc8inx 5051 6 the the DT cord-010092-uftc8inx 5051 7 blood blood NN cord-010092-uftc8inx 5051 8 supply supply NN cord-010092-uftc8inx 5051 9 of of IN cord-010092-uftc8inx 5051 10 tertiary tertiary JJ cord-010092-uftc8inx 5051 11 care care NN cord-010092-uftc8inx 5051 12 hospital hospital NN cord-010092-uftc8inx 5051 13 . . . cord-010092-uftc8inx 5052 1 Background background NN cord-010092-uftc8inx 5052 2 : : : cord-010092-uftc8inx 5053 1 Donor donor NN cord-010092-uftc8inx 5053 2 selection selection NN cord-010092-uftc8inx 5053 3 is be VBZ cord-010092-uftc8inx 5053 4 the the DT cord-010092-uftc8inx 5053 5 first first JJ cord-010092-uftc8inx 5053 6 step step NN cord-010092-uftc8inx 5053 7 towards towards IN cord-010092-uftc8inx 5053 8 safe safe JJ cord-010092-uftc8inx 5053 9 blood blood NN cord-010092-uftc8inx 5053 10 but but CC cord-010092-uftc8inx 5053 11 retaining retain VBG cord-010092-uftc8inx 5053 12 blood blood NN cord-010092-uftc8inx 5053 13 donors donor NNS cord-010092-uftc8inx 5053 14 is be VBZ cord-010092-uftc8inx 5053 15 also also RB cord-010092-uftc8inx 5053 16 very very RB cord-010092-uftc8inx 5053 17 important important JJ cord-010092-uftc8inx 5053 18 for for IN cord-010092-uftc8inx 5053 19 the the DT cord-010092-uftc8inx 5053 20 blood blood NN cord-010092-uftc8inx 5053 21 supply supply NN cord-010092-uftc8inx 5053 22 . . . cord-010092-uftc8inx 5054 1 Donor donor NN cord-010092-uftc8inx 5054 2 questionnaire questionnaire NN cord-010092-uftc8inx 5054 3 and and CC cord-010092-uftc8inx 5054 4 the the DT cord-010092-uftc8inx 5054 5 medical medical JJ cord-010092-uftc8inx 5054 6 interview interview NN cord-010092-uftc8inx 5054 7 should should MD cord-010092-uftc8inx 5054 8 provide provide VB cord-010092-uftc8inx 5054 9 optimal optimal JJ cord-010092-uftc8inx 5054 10 doctor doctor NN cord-010092-uftc8inx 5054 11 deferral deferral NN cord-010092-uftc8inx 5054 12 . . . cord-010092-uftc8inx 5055 1 Aims aim VBZ cord-010092-uftc8inx 5055 2 : : : cord-010092-uftc8inx 5055 3 To to TO cord-010092-uftc8inx 5055 4 evaluate evaluate VB cord-010092-uftc8inx 5055 5 deferral deferral NN cord-010092-uftc8inx 5055 6 rate rate NN cord-010092-uftc8inx 5055 7 in in IN cord-010092-uftc8inx 5055 8 blood blood NN cord-010092-uftc8inx 5055 9 donors donor NNS cord-010092-uftc8inx 5055 10 in in IN cord-010092-uftc8inx 5055 11 order order NN cord-010092-uftc8inx 5055 12 to to TO cord-010092-uftc8inx 5055 13 identify identify VB cord-010092-uftc8inx 5055 14 the the DT cord-010092-uftc8inx 5055 15 main main JJ cord-010092-uftc8inx 5055 16 reasons reason NNS cord-010092-uftc8inx 5055 17 and and CC cord-010092-uftc8inx 5055 18 to to TO cord-010092-uftc8inx 5055 19 target target VB cord-010092-uftc8inx 5055 20 eventual eventual JJ cord-010092-uftc8inx 5055 21 corrective corrective JJ cord-010092-uftc8inx 5055 22 activities activity NNS cord-010092-uftc8inx 5055 23 . . . cord-010092-uftc8inx 5056 1 Methods method NNS cord-010092-uftc8inx 5056 2 : : : cord-010092-uftc8inx 5056 3 We -PRON- PRP cord-010092-uftc8inx 5056 4 analysed analyse VBD cord-010092-uftc8inx 5056 5 the the DT cord-010092-uftc8inx 5056 6 data datum NNS cord-010092-uftc8inx 5056 7 concerning concern VBG cord-010092-uftc8inx 5056 8 blood blood NN cord-010092-uftc8inx 5056 9 donors donor NNS cord-010092-uftc8inx 5056 10 who who WP cord-010092-uftc8inx 5056 11 were be VBD cord-010092-uftc8inx 5056 12 registered register VBN cord-010092-uftc8inx 5056 13 in in IN cord-010092-uftc8inx 5056 14 the the DT cord-010092-uftc8inx 5056 15 period period NN cord-010092-uftc8inx 5056 16 of of IN cord-010092-uftc8inx 5056 17 three three CD cord-010092-uftc8inx 5056 18 years year NNS cord-010092-uftc8inx 5056 19 ( ( -LRB- cord-010092-uftc8inx 5056 20 2016 2016 CD cord-010092-uftc8inx 5056 21 - - SYM cord-010092-uftc8inx 5056 22 2018 2018 CD cord-010092-uftc8inx 5056 23 ) ) -RRB- cord-010092-uftc8inx 5056 24 . . . cord-010092-uftc8inx 5057 1 We -PRON- PRP cord-010092-uftc8inx 5057 2 used use VBD cord-010092-uftc8inx 5057 3 data datum NNS cord-010092-uftc8inx 5057 4 from from IN cord-010092-uftc8inx 5057 5 the the DT cord-010092-uftc8inx 5057 6 information information NN cord-010092-uftc8inx 5057 7 system system NN cord-010092-uftc8inx 5057 8 e e NNP cord-010092-uftc8inx 5057 9 - - : cord-010092-uftc8inx 5057 10 Delphyn Delphyn NNP cord-010092-uftc8inx 5057 11 . . . cord-010092-uftc8inx 5058 1 Background background NN cord-010092-uftc8inx 5058 2 : : : cord-010092-uftc8inx 5059 1 Iron iron NN cord-010092-uftc8inx 5059 2 deficiency deficiency NN cord-010092-uftc8inx 5059 3 ( ( -LRB- cord-010092-uftc8inx 5059 4 ID ID NNP cord-010092-uftc8inx 5059 5 ) ) -RRB- cord-010092-uftc8inx 5059 6 in in IN cord-010092-uftc8inx 5059 7 blood blood NN cord-010092-uftc8inx 5059 8 donors donor NNS cord-010092-uftc8inx 5059 9 is be VBZ cord-010092-uftc8inx 5059 10 an an DT cord-010092-uftc8inx 5059 11 underestimated underestimated JJ cord-010092-uftc8inx 5059 12 issue issue NN cord-010092-uftc8inx 5059 13 in in IN cord-010092-uftc8inx 5059 14 many many JJ cord-010092-uftc8inx 5059 15 countries country NNS cord-010092-uftc8inx 5059 16 and and CC cord-010092-uftc8inx 5059 17 may may MD cord-010092-uftc8inx 5059 18 cause cause VB cord-010092-uftc8inx 5059 19 symptoms symptom NNS cord-010092-uftc8inx 5059 20 to to IN cord-010092-uftc8inx 5059 21 blood blood NN cord-010092-uftc8inx 5059 22 donors donor NNS cord-010092-uftc8inx 5059 23 even even RB cord-010092-uftc8inx 5059 24 without without IN cord-010092-uftc8inx 5059 25 anemia anemia NN cord-010092-uftc8inx 5059 26 . . . cord-010092-uftc8inx 5060 1 ID ID NNP cord-010092-uftc8inx 5060 2 prevention prevention NN cord-010092-uftc8inx 5060 3 is be VBZ cord-010092-uftc8inx 5060 4 mainly mainly RB cord-010092-uftc8inx 5060 5 based base VBN cord-010092-uftc8inx 5060 6 on on IN cord-010092-uftc8inx 5060 7 the the DT cord-010092-uftc8inx 5060 8 prevention prevention NN cord-010092-uftc8inx 5060 9 of of IN cord-010092-uftc8inx 5060 10 anemia anemia NN cord-010092-uftc8inx 5060 11 in in IN cord-010092-uftc8inx 5060 12 whole whole JJ cord-010092-uftc8inx 5060 13 blood blood NN cord-010092-uftc8inx 5060 14 donors donor NNS cord-010092-uftc8inx 5060 15 , , , cord-010092-uftc8inx 5060 16 which which WDT cord-010092-uftc8inx 5060 17 is be VBZ cord-010092-uftc8inx 5060 18 done do VBN cord-010092-uftc8inx 5060 19 by by IN cord-010092-uftc8inx 5060 20 deferring defer VBG cord-010092-uftc8inx 5060 21 donors donor NNS cord-010092-uftc8inx 5060 22 whose whose WP$ cord-010092-uftc8inx 5060 23 haemoglobin haemoglobin NN cord-010092-uftc8inx 5060 24 level level NN cord-010092-uftc8inx 5060 25 is be VBZ cord-010092-uftc8inx 5060 26 under under IN cord-010092-uftc8inx 5060 27 defined define VBN cord-010092-uftc8inx 5060 28 threshold threshold NN cord-010092-uftc8inx 5060 29 ( ( -LRB- cord-010092-uftc8inx 5060 30 120 120 CD cord-010092-uftc8inx 5060 31 g g NN cord-010092-uftc8inx 5060 32 / / SYM cord-010092-uftc8inx 5060 33 L l NN cord-010092-uftc8inx 5060 34 in in IN cord-010092-uftc8inx 5060 35 women woman NNS cord-010092-uftc8inx 5060 36 , , , cord-010092-uftc8inx 5060 37 130 130 CD cord-010092-uftc8inx 5060 38 g g NN cord-010092-uftc8inx 5060 39 / / SYM cord-010092-uftc8inx 5060 40 L l NN cord-010092-uftc8inx 5060 41 in in IN cord-010092-uftc8inx 5060 42 men man NNS cord-010092-uftc8inx 5060 43 in in IN cord-010092-uftc8inx 5060 44 France France NNP cord-010092-uftc8inx 5060 45 ) ) -RRB- cord-010092-uftc8inx 5060 46 . . . cord-010092-uftc8inx 5061 1 EFS EFS NNP cord-010092-uftc8inx 5061 2 ( ( -LRB- cord-010092-uftc8inx 5061 3 French french JJ cord-010092-uftc8inx 5061 4 blood blood NN cord-010092-uftc8inx 5061 5 establishment establishment NN cord-010092-uftc8inx 5061 6 ) ) -RRB- cord-010092-uftc8inx 5061 7 studies study NNS cord-010092-uftc8inx 5061 8 has have VBZ cord-010092-uftc8inx 5061 9 observed observe VBN cord-010092-uftc8inx 5061 10 that that IN cord-010092-uftc8inx 5061 11 the the DT cord-010092-uftc8inx 5061 12 rate rate NN cord-010092-uftc8inx 5061 13 of of IN cord-010092-uftc8inx 5061 14 deferral deferral NN cord-010092-uftc8inx 5061 15 for for IN cord-010092-uftc8inx 5061 16 anemia anemia NN cord-010092-uftc8inx 5061 17 is be VBZ cord-010092-uftc8inx 5061 18 significantly significantly RB cord-010092-uftc8inx 5061 19 higher high JJR cord-010092-uftc8inx 5061 20 in in IN cord-010092-uftc8inx 5061 21 women woman NNS cord-010092-uftc8inx 5061 22 than than IN cord-010092-uftc8inx 5061 23 in in IN cord-010092-uftc8inx 5061 24 men man NNS cord-010092-uftc8inx 5061 25 , , , cord-010092-uftc8inx 5061 26 either either CC cord-010092-uftc8inx 5061 27 in in IN cord-010092-uftc8inx 5061 28 French french JJ cord-010092-uftc8inx 5061 29 West West NNP cord-010092-uftc8inx 5061 30 Indies Indies NNPS cord-010092-uftc8inx 5061 31 ( ( -LRB- cord-010092-uftc8inx 5061 32 15.9 15.9 CD cord-010092-uftc8inx 5061 33 % % NN cord-010092-uftc8inx 5061 34 versus versus IN cord-010092-uftc8inx 5061 35 3.4 3.4 CD cord-010092-uftc8inx 5061 36 % % NN cord-010092-uftc8inx 5061 37 ) ) -RRB- cord-010092-uftc8inx 5061 38 or or CC cord-010092-uftc8inx 5061 39 in in IN cord-010092-uftc8inx 5061 40 continental continental JJ cord-010092-uftc8inx 5061 41 France France NNP cord-010092-uftc8inx 5061 42 ( ( -LRB- cord-010092-uftc8inx 5061 43 2.9 2.9 CD cord-010092-uftc8inx 5061 44 % % NN cord-010092-uftc8inx 5061 45 and and CC cord-010092-uftc8inx 5061 46 0.8 0.8 CD cord-010092-uftc8inx 5061 47 % % NN cord-010092-uftc8inx 5061 48 ) ) -RRB- cord-010092-uftc8inx 5061 49 . . . cord-010092-uftc8inx 5062 1 Assessing assess VBG cord-010092-uftc8inx 5062 2 the the DT cord-010092-uftc8inx 5062 3 prevalence prevalence NN cord-010092-uftc8inx 5062 4 of of IN cord-010092-uftc8inx 5062 5 ID ID NNP cord-010092-uftc8inx 5062 6 is be VBZ cord-010092-uftc8inx 5062 7 of of IN cord-010092-uftc8inx 5062 8 great great JJ cord-010092-uftc8inx 5062 9 interest interest NN cord-010092-uftc8inx 5062 10 since since IN cord-010092-uftc8inx 5062 11 strategies strategy NNS cord-010092-uftc8inx 5062 12 to to TO cord-010092-uftc8inx 5062 13 counteract counteract VB cord-010092-uftc8inx 5062 14 it -PRON- PRP cord-010092-uftc8inx 5062 15 must must MD cord-010092-uftc8inx 5062 16 deal deal VB cord-010092-uftc8inx 5062 17 with with IN cord-010092-uftc8inx 5062 18 donor donor NN cord-010092-uftc8inx 5062 19 health health NN cord-010092-uftc8inx 5062 20 and and CC cord-010092-uftc8inx 5062 21 self self NN cord-010092-uftc8inx 5062 22 - - HYPH cord-010092-uftc8inx 5062 23 supply supply NN cord-010092-uftc8inx 5062 24 . . . cord-010092-uftc8inx 5063 1 However however RB cord-010092-uftc8inx 5063 2 , , , cord-010092-uftc8inx 5063 3 data datum NNS cord-010092-uftc8inx 5063 4 on on IN cord-010092-uftc8inx 5063 5 ID ID NNP cord-010092-uftc8inx 5063 6 are be VBP cord-010092-uftc8inx 5063 7 missing miss VBG cord-010092-uftc8inx 5063 8 in in IN cord-010092-uftc8inx 5063 9 France France NNP cord-010092-uftc8inx 5063 10 . . . cord-010092-uftc8inx 5064 1 Aims aim VBZ cord-010092-uftc8inx 5064 2 : : : cord-010092-uftc8inx 5065 1 To to TO cord-010092-uftc8inx 5065 2 estimate estimate VB cord-010092-uftc8inx 5065 3 the the DT cord-010092-uftc8inx 5065 4 prevalence prevalence NN cord-010092-uftc8inx 5065 5 of of IN cord-010092-uftc8inx 5065 6 ID ID NNP cord-010092-uftc8inx 5065 7 in in IN cord-010092-uftc8inx 5065 8 French french JJ cord-010092-uftc8inx 5065 9 whole whole JJ cord-010092-uftc8inx 5065 10 blood blood NN cord-010092-uftc8inx 5065 11 donors donor NNS cord-010092-uftc8inx 5065 12 and and CC cord-010092-uftc8inx 5065 13 to to TO cord-010092-uftc8inx 5065 14 identify identify VB cord-010092-uftc8inx 5065 15 risk risk NN cord-010092-uftc8inx 5065 16 factors factor NNS cord-010092-uftc8inx 5065 17 associated associate VBN cord-010092-uftc8inx 5065 18 with with IN cord-010092-uftc8inx 5065 19 ID ID NNP cord-010092-uftc8inx 5065 20 . . . cord-010092-uftc8inx 5066 1 Methods method NNS cord-010092-uftc8inx 5066 2 : : : cord-010092-uftc8inx 5066 3 This this DT cord-010092-uftc8inx 5066 4 non non JJ cord-010092-uftc8inx 5066 5 - - JJ cord-010092-uftc8inx 5066 6 interventional interventional JJ cord-010092-uftc8inx 5066 7 , , , cord-010092-uftc8inx 5066 8 cross cross JJ cord-010092-uftc8inx 5066 9 - - JJ cord-010092-uftc8inx 5066 10 sectional sectional JJ cord-010092-uftc8inx 5066 11 , , , cord-010092-uftc8inx 5066 12 multicenter multicenter JJ cord-010092-uftc8inx 5066 13 study study NN cord-010092-uftc8inx 5066 14 is be VBZ cord-010092-uftc8inx 5066 15 performed perform VBN cord-010092-uftc8inx 5066 16 in in IN cord-010092-uftc8inx 5066 17 blood blood NN cord-010092-uftc8inx 5066 18 donors donor NNS cord-010092-uftc8inx 5066 19 of of IN cord-010092-uftc8inx 5066 20 EFS EFS NNP cord-010092-uftc8inx 5066 21 and and CC cord-010092-uftc8inx 5066 22 CTSA CTSA NNP cord-010092-uftc8inx 5067 1 ( ( -LRB- cord-010092-uftc8inx 5067 2 Blood Blood NNP cord-010092-uftc8inx 5067 3 Center Center NNP cord-010092-uftc8inx 5067 4 of of IN cord-010092-uftc8inx 5067 5 the the DT cord-010092-uftc8inx 5067 6 French French NNP cord-010092-uftc8inx 5067 7 Military Military NNP cord-010092-uftc8inx 5067 8 Health Health NNP cord-010092-uftc8inx 5067 9 Service Service NNP cord-010092-uftc8inx 5067 10 ) ) -RRB- cord-010092-uftc8inx 5067 11 . . . cord-010092-uftc8inx 5068 1 All all DT cord-010092-uftc8inx 5068 2 whole whole JJ cord-010092-uftc8inx 5068 3 blood blood NN cord-010092-uftc8inx 5068 4 donors donor NNS cord-010092-uftc8inx 5068 5 who who WP cord-010092-uftc8inx 5068 6 met meet VBD cord-010092-uftc8inx 5068 7 selection selection NN cord-010092-uftc8inx 5068 8 criteria criterion NNS cord-010092-uftc8inx 5068 9 are be VBP cord-010092-uftc8inx 5068 10 potentially potentially RB cord-010092-uftc8inx 5068 11 included include VBN cord-010092-uftc8inx 5068 12 . . . cord-010092-uftc8inx 5069 1 Donors donor NNS cord-010092-uftc8inx 5069 2 coming come VBG cord-010092-uftc8inx 5069 3 for for IN cord-010092-uftc8inx 5069 4 bloodletting bloodletting NN cord-010092-uftc8inx 5069 5 and and CC cord-010092-uftc8inx 5069 6 donors donor NNS cord-010092-uftc8inx 5069 7 who who WP cord-010092-uftc8inx 5069 8 refuse refuse VBP cord-010092-uftc8inx 5069 9 to to TO cord-010092-uftc8inx 5069 10 participate participate VB cord-010092-uftc8inx 5069 11 to to IN cord-010092-uftc8inx 5069 12 the the DT cord-010092-uftc8inx 5069 13 study study NN cord-010092-uftc8inx 5069 14 are be VBP cord-010092-uftc8inx 5069 15 excluded exclude VBN cord-010092-uftc8inx 5069 16 . . . cord-010092-uftc8inx 5070 1 No no DT cord-010092-uftc8inx 5070 2 additional additional JJ cord-010092-uftc8inx 5070 3 sample sample NN cord-010092-uftc8inx 5070 4 is be VBZ cord-010092-uftc8inx 5070 5 taken take VBN cord-010092-uftc8inx 5070 6 for for IN cord-010092-uftc8inx 5070 7 the the DT cord-010092-uftc8inx 5070 8 study study NN cord-010092-uftc8inx 5070 9 , , , cord-010092-uftc8inx 5070 10 ferritin ferritin NN cord-010092-uftc8inx 5070 11 is be VBZ cord-010092-uftc8inx 5070 12 tested test VBN cord-010092-uftc8inx 5070 13 after after IN cord-010092-uftc8inx 5070 14 blood blood NN cord-010092-uftc8inx 5070 15 qualification qualification NN cord-010092-uftc8inx 5070 16 on on IN cord-010092-uftc8inx 5070 17 surplus surplus NN cord-010092-uftc8inx 5070 18 amount amount NN cord-010092-uftc8inx 5070 19 . . . cord-010092-uftc8inx 5071 1 Samples sample NNS cord-010092-uftc8inx 5071 2 are be VBP cord-010092-uftc8inx 5071 3 selected select VBN cord-010092-uftc8inx 5071 4 at at IN cord-010092-uftc8inx 5071 5 random random JJ cord-010092-uftc8inx 5071 6 within within IN cord-010092-uftc8inx 5071 7 all all PDT cord-010092-uftc8inx 5071 8 the the DT cord-010092-uftc8inx 5071 9 geographical geographical JJ cord-010092-uftc8inx 5071 10 areas area NNS cord-010092-uftc8inx 5071 11 and and CC cord-010092-uftc8inx 5071 12 all all DT cord-010092-uftc8inx 5071 13 mobile mobile JJ cord-010092-uftc8inx 5071 14 blood blood NN cord-010092-uftc8inx 5071 15 drives drive NNS cord-010092-uftc8inx 5071 16 and and CC cord-010092-uftc8inx 5071 17 blood blood NN cord-010092-uftc8inx 5071 18 centers center NNS cord-010092-uftc8inx 5071 19 between between IN cord-010092-uftc8inx 5071 20 March March NNP cord-010092-uftc8inx 5071 21 11 11 CD cord-010092-uftc8inx 5071 22 and and CC cord-010092-uftc8inx 5071 23 March March NNP cord-010092-uftc8inx 5071 24 28 28 CD cord-010092-uftc8inx 5071 25 , , , cord-010092-uftc8inx 5071 26 2019 2019 CD cord-010092-uftc8inx 5071 27 . . . cord-010092-uftc8inx 5072 1 Results result NNS cord-010092-uftc8inx 5072 2 : : : cord-010092-uftc8inx 5073 1 This this DT cord-010092-uftc8inx 5073 2 study study NN cord-010092-uftc8inx 5073 3 FERRIDON FERRIDON NNP cord-010092-uftc8inx 5073 4 has have VBZ cord-010092-uftc8inx 5073 5 been be VBN cord-010092-uftc8inx 5073 6 approved approve VBN cord-010092-uftc8inx 5073 7 by by IN cord-010092-uftc8inx 5073 8 ethical ethical JJ cord-010092-uftc8inx 5073 9 research research NN cord-010092-uftc8inx 5073 10 committee committee NN cord-010092-uftc8inx 5073 11 . . . cord-010092-uftc8inx 5074 1 Nine nine CD cord-010092-uftc8inx 5074 2 thousand thousand CD cord-010092-uftc8inx 5074 3 ( ( -LRB- cord-010092-uftc8inx 5074 4 9000 9000 CD cord-010092-uftc8inx 5074 5 ) ) -RRB- cord-010092-uftc8inx 5075 1 whole whole JJ cord-010092-uftc8inx 5075 2 blood blood NN cord-010092-uftc8inx 5075 3 donors donor NNS cord-010092-uftc8inx 5075 4 will will MD cord-010092-uftc8inx 5075 5 be be VB cord-010092-uftc8inx 5075 6 included include VBN cord-010092-uftc8inx 5075 7 in in IN cord-010092-uftc8inx 5075 8 EFS EFS NNP cord-010092-uftc8inx 5075 9 centers center NNS cord-010092-uftc8inx 5075 10 in in IN cord-010092-uftc8inx 5075 11 continental continental JJ cord-010092-uftc8inx 5075 12 France France NNP cord-010092-uftc8inx 5075 13 . . . cord-010092-uftc8inx 5076 1 To to TO cord-010092-uftc8inx 5076 2 have have VB cord-010092-uftc8inx 5076 3 information information NN cord-010092-uftc8inx 5076 4 on on IN cord-010092-uftc8inx 5076 5 donors donor NNS cord-010092-uftc8inx 5076 6 of of IN cord-010092-uftc8inx 5076 7 Afro Afro NNP cord-010092-uftc8inx 5076 8 - - HYPH cord-010092-uftc8inx 5076 9 Caribbean caribbean JJ cord-010092-uftc8inx 5076 10 origin origin NN cord-010092-uftc8inx 5076 11 and and CC cord-010092-uftc8inx 5076 12 Comoros Comoros NNP cord-010092-uftc8inx 5076 13 origin origin NN cord-010092-uftc8inx 5076 14 , , , cord-010092-uftc8inx 5076 15 150 150 CD cord-010092-uftc8inx 5076 16 donations donation NNS cord-010092-uftc8inx 5076 17 should should MD cord-010092-uftc8inx 5076 18 be be VB cord-010092-uftc8inx 5076 19 included include VBN cord-010092-uftc8inx 5076 20 in in IN cord-010092-uftc8inx 5076 21 the the DT cord-010092-uftc8inx 5076 22 French french JJ cord-010092-uftc8inx 5076 23 West West NNP cord-010092-uftc8inx 5076 24 Indies Indies NNPS cord-010092-uftc8inx 5076 25 and and CC cord-010092-uftc8inx 5076 26 120 120 CD cord-010092-uftc8inx 5076 27 in in IN cord-010092-uftc8inx 5076 28 Reunion Reunion NNP cord-010092-uftc8inx 5076 29 Island Island NNP cord-010092-uftc8inx 5076 30 . . . cord-010092-uftc8inx 5077 1 Additionally additionally RB cord-010092-uftc8inx 5077 2 , , , cord-010092-uftc8inx 5077 3 1500 1500 CD cord-010092-uftc8inx 5077 4 whole whole JJ cord-010092-uftc8inx 5077 5 blood blood NN cord-010092-uftc8inx 5077 6 donors donor NNS cord-010092-uftc8inx 5077 7 will will MD cord-010092-uftc8inx 5077 8 be be VB cord-010092-uftc8inx 5077 9 included include VBN cord-010092-uftc8inx 5077 10 in in IN cord-010092-uftc8inx 5077 11 CTSA CTSA NNP cord-010092-uftc8inx 5077 12 centers center NNS cord-010092-uftc8inx 5077 13 . . . cord-010092-uftc8inx 5078 1 In in IN cord-010092-uftc8inx 5078 2 this this DT cord-010092-uftc8inx 5078 3 study study NN cord-010092-uftc8inx 5078 4 , , , cord-010092-uftc8inx 5078 5 ID ID NNP cord-010092-uftc8inx 5078 6 is be VBZ cord-010092-uftc8inx 5078 7 defined define VBN cord-010092-uftc8inx 5078 8 by by IN cord-010092-uftc8inx 5078 9 ferritin ferritin NN cord-010092-uftc8inx 5078 10 lower low JJR cord-010092-uftc8inx 5078 11 than than IN cord-010092-uftc8inx 5078 12 26 26 CD cord-010092-uftc8inx 5078 13 ng ng NN cord-010092-uftc8inx 5078 14 / / SYM cord-010092-uftc8inx 5078 15 mL ml NN cord-010092-uftc8inx 5078 16 and and CC cord-010092-uftc8inx 5078 17 iron iron NN cord-010092-uftc8inx 5078 18 overload overload NN cord-010092-uftc8inx 5078 19 is be VBZ cord-010092-uftc8inx 5078 20 defined define VBN cord-010092-uftc8inx 5078 21 by by IN cord-010092-uftc8inx 5078 22 ferritin ferritin NN cord-010092-uftc8inx 5078 23 higher high JJR cord-010092-uftc8inx 5078 24 than than IN cord-010092-uftc8inx 5078 25 300 300 CD cord-010092-uftc8inx 5078 26 ng ng NN cord-010092-uftc8inx 5078 27 / / SYM cord-010092-uftc8inx 5078 28 mL. ml. NN cord-010092-uftc8inx 5079 1 All all DT cord-010092-uftc8inx 5079 2 donors donor NNS cord-010092-uftc8inx 5079 3 with with IN cord-010092-uftc8inx 5079 4 iron iron NN cord-010092-uftc8inx 5079 5 deficiency deficiency NN cord-010092-uftc8inx 5079 6 or or CC cord-010092-uftc8inx 5079 7 overload overload NN cord-010092-uftc8inx 5079 8 will will MD cord-010092-uftc8inx 5079 9 received receive VBN cord-010092-uftc8inx 5079 10 a a DT cord-010092-uftc8inx 5079 11 letter letter NN cord-010092-uftc8inx 5079 12 advising advise VBG cord-010092-uftc8inx 5079 13 to to TO cord-010092-uftc8inx 5079 14 consult consult VB cord-010092-uftc8inx 5079 15 their -PRON- PRP$ cord-010092-uftc8inx 5079 16 general general JJ cord-010092-uftc8inx 5079 17 practitioner practitioner NN cord-010092-uftc8inx 5079 18 . . . cord-010092-uftc8inx 5080 1 Weights weight NNS cord-010092-uftc8inx 5080 2 will will MD cord-010092-uftc8inx 5080 3 be be VB cord-010092-uftc8inx 5080 4 calibrated calibrate VBN cord-010092-uftc8inx 5080 5 on on IN cord-010092-uftc8inx 5080 6 age age NN cord-010092-uftc8inx 5080 7 , , , cord-010092-uftc8inx 5080 8 sex sex NN cord-010092-uftc8inx 5080 9 and and CC cord-010092-uftc8inx 5080 10 geographical geographical JJ cord-010092-uftc8inx 5080 11 area area NN cord-010092-uftc8inx 5081 1 so so IN cord-010092-uftc8inx 5081 2 the the DT cord-010092-uftc8inx 5081 3 sample sample NN cord-010092-uftc8inx 5081 4 will will MD cord-010092-uftc8inx 5081 5 be be VB cord-010092-uftc8inx 5081 6 representative representative JJ cord-010092-uftc8inx 5081 7 of of IN cord-010092-uftc8inx 5081 8 the the DT cord-010092-uftc8inx 5081 9 French french JJ cord-010092-uftc8inx 5081 10 whole whole JJ cord-010092-uftc8inx 5081 11 blood blood NN cord-010092-uftc8inx 5081 12 donors donor NNS cord-010092-uftc8inx 5081 13 . . . cord-010092-uftc8inx 5082 1 Estimation estimation NN cord-010092-uftc8inx 5082 2 of of IN cord-010092-uftc8inx 5082 3 ID ID NNP cord-010092-uftc8inx 5082 4 prevalence prevalence NN cord-010092-uftc8inx 5082 5 will will MD cord-010092-uftc8inx 5082 6 take take VB cord-010092-uftc8inx 5082 7 into into IN cord-010092-uftc8inx 5082 8 account account NN cord-010092-uftc8inx 5082 9 the the DT cord-010092-uftc8inx 5082 10 weights weight NNS cord-010092-uftc8inx 5082 11 and and CC cord-010092-uftc8inx 5082 12 logistic logistic JJ cord-010092-uftc8inx 5082 13 regression regression NN cord-010092-uftc8inx 5082 14 model model NN cord-010092-uftc8inx 5082 15 will will MD cord-010092-uftc8inx 5082 16 be be VB cord-010092-uftc8inx 5082 17 used use VBN cord-010092-uftc8inx 5082 18 to to TO cord-010092-uftc8inx 5082 19 analyze analyze VB cord-010092-uftc8inx 5082 20 risk risk NN cord-010092-uftc8inx 5082 21 factors factor NNS cord-010092-uftc8inx 5082 22 associated associate VBN cord-010092-uftc8inx 5082 23 with with IN cord-010092-uftc8inx 5082 24 ID ID NNP cord-010092-uftc8inx 5082 25 . . . cord-010092-uftc8inx 5083 1 Data datum NNS cord-010092-uftc8inx 5083 2 will will MD cord-010092-uftc8inx 5083 3 be be VB cord-010092-uftc8inx 5083 4 analyzed analyze VBN cord-010092-uftc8inx 5083 5 during during IN cord-010092-uftc8inx 5083 6 April April NNP cord-010092-uftc8inx 5083 7 and and CC cord-010092-uftc8inx 5083 8 May May NNP cord-010092-uftc8inx 5083 9 2019 2019 CD cord-010092-uftc8inx 5083 10 to to TO cord-010092-uftc8inx 5083 11 get get VB cord-010092-uftc8inx 5083 12 result result NN cord-010092-uftc8inx 5083 13 at at IN cord-010092-uftc8inx 5083 14 the the DT cord-010092-uftc8inx 5083 15 end end NN cord-010092-uftc8inx 5083 16 of of IN cord-010092-uftc8inx 5083 17 May. May NNP cord-010092-uftc8inx 5083 18 Summary Summary NNP cord-010092-uftc8inx 5083 19 / / SYM cord-010092-uftc8inx 5083 20 Conclusions conclusion NNS cord-010092-uftc8inx 5083 21 : : : cord-010092-uftc8inx 5083 22 FERRIDON FERRIDON NNP cord-010092-uftc8inx 5083 23 will will MD cord-010092-uftc8inx 5083 24 be be VB cord-010092-uftc8inx 5083 25 the the DT cord-010092-uftc8inx 5083 26 first first JJ cord-010092-uftc8inx 5083 27 study study NN cord-010092-uftc8inx 5083 28 on on IN cord-010092-uftc8inx 5083 29 ID ID NNP cord-010092-uftc8inx 5083 30 in in IN cord-010092-uftc8inx 5083 31 the the DT cord-010092-uftc8inx 5083 32 French french JJ cord-010092-uftc8inx 5083 33 blood blood NN cord-010092-uftc8inx 5083 34 donors donor NNS cord-010092-uftc8inx 5083 35 . . . cord-010092-uftc8inx 5084 1 Considering consider VBG cord-010092-uftc8inx 5084 2 the the DT cord-010092-uftc8inx 5084 3 French french JJ cord-010092-uftc8inx 5084 4 health health NN cord-010092-uftc8inx 5084 5 care care NN cord-010092-uftc8inx 5084 6 system system NN cord-010092-uftc8inx 5084 7 and and CC cord-010092-uftc8inx 5084 8 diet diet NN cord-010092-uftc8inx 5084 9 , , , cord-010092-uftc8inx 5084 10 it -PRON- PRP cord-010092-uftc8inx 5084 11 will will MD cord-010092-uftc8inx 5084 12 be be VB cord-010092-uftc8inx 5084 13 interesting interesting JJ cord-010092-uftc8inx 5084 14 to to TO cord-010092-uftc8inx 5084 15 compare compare VB cord-010092-uftc8inx 5084 16 those those DT cord-010092-uftc8inx 5084 17 results result NNS cord-010092-uftc8inx 5084 18 to to IN cord-010092-uftc8inx 5084 19 results result NNS cord-010092-uftc8inx 5084 20 from from IN cord-010092-uftc8inx 5084 21 other other JJ cord-010092-uftc8inx 5084 22 countries country NNS cord-010092-uftc8inx 5084 23 . . . cord-010092-uftc8inx 5085 1 Mostly mostly RB cord-010092-uftc8inx 5085 2 this this DT cord-010092-uftc8inx 5085 3 study study NN cord-010092-uftc8inx 5085 4 will will MD cord-010092-uftc8inx 5085 5 allow allow VB cord-010092-uftc8inx 5085 6 to to TO cord-010092-uftc8inx 5085 7 consider consider VB cord-010092-uftc8inx 5085 8 various various JJ cord-010092-uftc8inx 5085 9 strategies strategy NNS cord-010092-uftc8inx 5085 10 dealing deal VBG cord-010092-uftc8inx 5085 11 both both CC cord-010092-uftc8inx 5085 12 with with IN cord-010092-uftc8inx 5085 13 donor donor NN cord-010092-uftc8inx 5085 14 safety safety NN cord-010092-uftc8inx 5085 15 and and CC cord-010092-uftc8inx 5085 16 self self NN cord-010092-uftc8inx 5085 17 - - HYPH cord-010092-uftc8inx 5085 18 supply supply NN cord-010092-uftc8inx 5085 19 . . . cord-010092-uftc8inx 5086 1 Background background NN cord-010092-uftc8inx 5086 2 : : : cord-010092-uftc8inx 5087 1 In in IN cord-010092-uftc8inx 5087 2 Portugal Portugal NNP cord-010092-uftc8inx 5087 3 , , , cord-010092-uftc8inx 5087 4 with with IN cord-010092-uftc8inx 5087 5 an an DT cord-010092-uftc8inx 5087 6 aging age VBG cord-010092-uftc8inx 5087 7 population population NN cord-010092-uftc8inx 5087 8 of of IN cord-010092-uftc8inx 5087 9 around around RB cord-010092-uftc8inx 5087 10 10 10 CD cord-010092-uftc8inx 5087 11 million million CD cord-010092-uftc8inx 5087 12 people people NNS cord-010092-uftc8inx 5087 13 , , , cord-010092-uftc8inx 5087 14 only only RB cord-010092-uftc8inx 5087 15 3.8 3.8 CD cord-010092-uftc8inx 5087 16 % % NN cord-010092-uftc8inx 5087 17 are be VBP cord-010092-uftc8inx 5087 18 blood blood NN cord-010092-uftc8inx 5087 19 donors donor NNS cord-010092-uftc8inx 5087 20 . . . cord-010092-uftc8inx 5088 1 The the DT cord-010092-uftc8inx 5088 2 country country NN cord-010092-uftc8inx 5088 3 has have VBZ cord-010092-uftc8inx 5088 4 a a DT cord-010092-uftc8inx 5088 5 national national JJ cord-010092-uftc8inx 5088 6 center center NN cord-010092-uftc8inx 5088 7 of of IN cord-010092-uftc8inx 5088 8 blood blood NN cord-010092-uftc8inx 5088 9 supply supply NN cord-010092-uftc8inx 5088 10 and and CC cord-010092-uftc8inx 5088 11 some some DT cord-010092-uftc8inx 5088 12 central central JJ cord-010092-uftc8inx 5088 13 hospitals hospital NNS cord-010092-uftc8inx 5088 14 with with IN cord-010092-uftc8inx 5088 15 a a DT cord-010092-uftc8inx 5088 16 blood blood NN cord-010092-uftc8inx 5088 17 donation donation NN cord-010092-uftc8inx 5088 18 center center NN cord-010092-uftc8inx 5088 19 . . . cord-010092-uftc8inx 5089 1 Despite despite IN cord-010092-uftc8inx 5089 2 the the DT cord-010092-uftc8inx 5089 3 growing grow VBG cord-010092-uftc8inx 5089 4 practice practice NN cord-010092-uftc8inx 5089 5 of of IN cord-010092-uftc8inx 5089 6 the the DT cord-010092-uftc8inx 5089 7 excellent excellent JJ cord-010092-uftc8inx 5089 8 concepts concept NNS cord-010092-uftc8inx 5089 9 of of IN cord-010092-uftc8inx 5089 10 patient patient JJ cord-010092-uftc8inx 5089 11 blood blood NN cord-010092-uftc8inx 5089 12 management management NN cord-010092-uftc8inx 5089 13 , , , cord-010092-uftc8inx 5089 14 it -PRON- PRP cord-010092-uftc8inx 5089 15 is be VBZ cord-010092-uftc8inx 5089 16 imperious imperious JJ cord-010092-uftc8inx 5089 17 to to TO cord-010092-uftc8inx 5089 18 attract attract VB cord-010092-uftc8inx 5089 19 new new JJ cord-010092-uftc8inx 5089 20 donors donor NNS cord-010092-uftc8inx 5089 21 . . . cord-010092-uftc8inx 5090 1 This this DT cord-010092-uftc8inx 5090 2 need need NN cord-010092-uftc8inx 5090 3 has have VBZ cord-010092-uftc8inx 5090 4 been be VBN cord-010092-uftc8inx 5090 5 our -PRON- PRP$ cord-010092-uftc8inx 5090 6 inspiration inspiration NN cord-010092-uftc8inx 5090 7 to to TO cord-010092-uftc8inx 5090 8 use use VB cord-010092-uftc8inx 5090 9 new new JJ cord-010092-uftc8inx 5090 10 approaches approach NNS cord-010092-uftc8inx 5090 11 towards towards IN cord-010092-uftc8inx 5090 12 people people NNS cord-010092-uftc8inx 5090 13 , , , cord-010092-uftc8inx 5090 14 in in IN cord-010092-uftc8inx 5090 15 a a DT cord-010092-uftc8inx 5090 16 constant constant JJ cord-010092-uftc8inx 5090 17 work work NN cord-010092-uftc8inx 5090 18 of of IN cord-010092-uftc8inx 5090 19 promotion promotion NN cord-010092-uftc8inx 5090 20 . . . cord-010092-uftc8inx 5091 1 Aims aim VBZ cord-010092-uftc8inx 5091 2 : : : cord-010092-uftc8inx 5092 1 Reach reach VB cord-010092-uftc8inx 5092 2 the the DT cord-010092-uftc8inx 5092 3 majority majority NN cord-010092-uftc8inx 5092 4 of of IN cord-010092-uftc8inx 5092 5 our -PRON- PRP$ cord-010092-uftc8inx 5092 6 local local JJ cord-010092-uftc8inx 5092 7 population population NN cord-010092-uftc8inx 5092 8 using use VBG cord-010092-uftc8inx 5092 9 radio radio NN cord-010092-uftc8inx 5092 10 and and CC cord-010092-uftc8inx 5092 11 telecommunication telecommunication NN cord-010092-uftc8inx 5092 12 as as RB cord-010092-uftc8inx 5092 13 well well RB cord-010092-uftc8inx 5092 14 as as IN cord-010092-uftc8inx 5092 15 social social JJ cord-010092-uftc8inx 5092 16 networks network NNS cord-010092-uftc8inx 5092 17 in in IN cord-010092-uftc8inx 5092 18 an an DT cord-010092-uftc8inx 5092 19 attempt attempt NN cord-010092-uftc8inx 5092 20 to to TO cord-010092-uftc8inx 5092 21 raise raise VB cord-010092-uftc8inx 5092 22 the the DT cord-010092-uftc8inx 5092 23 number number NN cord-010092-uftc8inx 5092 24 of of IN cord-010092-uftc8inx 5092 25 new new JJ cord-010092-uftc8inx 5092 26 blood blood NN cord-010092-uftc8inx 5092 27 donors donor NNS cord-010092-uftc8inx 5092 28 in in IN cord-010092-uftc8inx 5092 29 a a DT cord-010092-uftc8inx 5092 30 central central JJ cord-010092-uftc8inx 5092 31 hospital hospital NN cord-010092-uftc8inx 5092 32 of of IN cord-010092-uftc8inx 5092 33 the the DT cord-010092-uftc8inx 5092 34 north north NN cord-010092-uftc8inx 5092 35 of of IN cord-010092-uftc8inx 5092 36 Portugal Portugal NNP cord-010092-uftc8inx 5092 37 . . . cord-010092-uftc8inx 5093 1 Methods method NNS cord-010092-uftc8inx 5093 2 : : : cord-010092-uftc8inx 5093 3 Active active JJ cord-010092-uftc8inx 5093 4 communication communication NN cord-010092-uftc8inx 5093 5 with with IN cord-010092-uftc8inx 5093 6 the the DT cord-010092-uftc8inx 5093 7 population population NN cord-010092-uftc8inx 5093 8 of of IN cord-010092-uftc8inx 5093 9 our -PRON- PRP$ cord-010092-uftc8inx 5093 10 reference reference NN cord-010092-uftc8inx 5093 11 area area NN cord-010092-uftc8inx 5093 12 , , , cord-010092-uftc8inx 5093 13 via via IN cord-010092-uftc8inx 5093 14 the the DT cord-010092-uftc8inx 5093 15 social social JJ cord-010092-uftc8inx 5093 16 networks network NNS cord-010092-uftc8inx 5093 17 Facebook Facebook NNP cord-010092-uftc8inx 5093 18 TM TM NNP cord-010092-uftc8inx 5093 19 and and CC cord-010092-uftc8inx 5093 20 Instagram Instagram NNP cord-010092-uftc8inx 5093 21 TM TM NNP cord-010092-uftc8inx 5093 22 , , , cord-010092-uftc8inx 5093 23 through through IN cord-010092-uftc8inx 5093 24 educational educational JJ cord-010092-uftc8inx 5093 25 digital digital JJ cord-010092-uftc8inx 5093 26 posters poster NNS cord-010092-uftc8inx 5093 27 and and CC cord-010092-uftc8inx 5093 28 messenger messenger NN cord-010092-uftc8inx 5093 29 service service NN cord-010092-uftc8inx 5093 30 to to TO cord-010092-uftc8inx 5093 31 answer answer VB cord-010092-uftc8inx 5093 32 any any DT cord-010092-uftc8inx 5093 33 kind kind NN cord-010092-uftc8inx 5093 34 of of IN cord-010092-uftc8inx 5093 35 questions question NNS cord-010092-uftc8inx 5093 36 . . . cord-010092-uftc8inx 5094 1 Establish establish VB cord-010092-uftc8inx 5094 2 contact contact NN cord-010092-uftc8inx 5094 3 with with IN cord-010092-uftc8inx 5094 4 radio radio NN cord-010092-uftc8inx 5094 5 and and CC cord-010092-uftc8inx 5094 6 television television NN cord-010092-uftc8inx 5094 7 stations station NNS cord-010092-uftc8inx 5094 8 as as RB cord-010092-uftc8inx 5094 9 well well RB cord-010092-uftc8inx 5094 10 as as IN cord-010092-uftc8inx 5094 11 with with IN cord-010092-uftc8inx 5094 12 the the DT cord-010092-uftc8inx 5094 13 mayor mayor NN cord-010092-uftc8inx 5094 14 of of IN cord-010092-uftc8inx 5094 15 the the DT cord-010092-uftc8inx 5094 16 city city NN cord-010092-uftc8inx 5094 17 , , , cord-010092-uftc8inx 5094 18 journalists journalist NNS cord-010092-uftc8inx 5094 19 , , , cord-010092-uftc8inx 5094 20 schools school NNS cord-010092-uftc8inx 5094 21 , , , cord-010092-uftc8inx 5094 22 town town NN cord-010092-uftc8inx 5094 23 hall hall NN cord-010092-uftc8inx 5094 24 deputies deputy NNS cord-010092-uftc8inx 5094 25 and and CC cord-010092-uftc8inx 5094 26 celebrities celebrity NNS cord-010092-uftc8inx 5094 27 , , , cord-010092-uftc8inx 5094 28 through through IN cord-010092-uftc8inx 5094 29 email email NN cord-010092-uftc8inx 5094 30 and and CC cord-010092-uftc8inx 5094 31 telephone telephone NN cord-010092-uftc8inx 5094 32 calls call NNS cord-010092-uftc8inx 5094 33 . . . cord-010092-uftc8inx 5095 1 Design design NN cord-010092-uftc8inx 5095 2 posters poster NNS cord-010092-uftc8inx 5095 3 , , , cord-010092-uftc8inx 5095 4 flyers flyer NNS cord-010092-uftc8inx 5095 5 and and CC cord-010092-uftc8inx 5095 6 public public JJ cord-010092-uftc8inx 5095 7 advertising advertising NN cord-010092-uftc8inx 5095 8 to to TO cord-010092-uftc8inx 5095 9 distribute distribute VB cord-010092-uftc8inx 5095 10 in in IN cord-010092-uftc8inx 5095 11 the the DT cord-010092-uftc8inx 5095 12 city city NN cord-010092-uftc8inx 5095 13 . . . cord-010092-uftc8inx 5096 1 Results result NNS cord-010092-uftc8inx 5096 2 : : : cord-010092-uftc8inx 5097 1 Through through IN cord-010092-uftc8inx 5097 2 the the DT cord-010092-uftc8inx 5097 3 social social JJ cord-010092-uftc8inx 5097 4 networks network NNS cord-010092-uftc8inx 5097 5 it -PRON- PRP cord-010092-uftc8inx 5097 6 has have VBZ cord-010092-uftc8inx 5097 7 been be VBN cord-010092-uftc8inx 5097 8 possible possible JJ cord-010092-uftc8inx 5097 9 to to TO cord-010092-uftc8inx 5097 10 reach reach VB cord-010092-uftc8inx 5097 11 a a DT cord-010092-uftc8inx 5097 12 population population NN cord-010092-uftc8inx 5097 13 of of IN cord-010092-uftc8inx 5097 14 dozens dozen NNS cord-010092-uftc8inx 5097 15 of of IN cord-010092-uftc8inx 5097 16 thousands thousand NNS cord-010092-uftc8inx 5097 17 in in IN cord-010092-uftc8inx 5097 18 our -PRON- PRP$ cord-010092-uftc8inx 5097 19 city city NN cord-010092-uftc8inx 5097 20 , , , cord-010092-uftc8inx 5097 21 in in IN cord-010092-uftc8inx 5097 22 a a DT cord-010092-uftc8inx 5097 23 daily daily JJ cord-010092-uftc8inx 5097 24 basis basis NN cord-010092-uftc8inx 5097 25 . . . cord-010092-uftc8inx 5098 1 The the DT cord-010092-uftc8inx 5098 2 national national JJ cord-010092-uftc8inx 5098 3 and and CC cord-010092-uftc8inx 5098 4 world world NN cord-010092-uftc8inx 5098 5 donor donor NN cord-010092-uftc8inx 5098 6 days day NNS cord-010092-uftc8inx 5098 7 were be VBD cord-010092-uftc8inx 5098 8 celebrated celebrate VBN cord-010092-uftc8inx 5098 9 with with IN cord-010092-uftc8inx 5098 10 success success NN cord-010092-uftc8inx 5098 11 , , , cord-010092-uftc8inx 5098 12 in in IN cord-010092-uftc8inx 5098 13 our -PRON- PRP$ cord-010092-uftc8inx 5098 14 health health NN cord-010092-uftc8inx 5098 15 facility facility NN cord-010092-uftc8inx 5098 16 , , , cord-010092-uftc8inx 5098 17 with with IN cord-010092-uftc8inx 5098 18 city city NN cord-010092-uftc8inx 5098 19 mayor mayor NN cord-010092-uftc8inx 5098 20 and and CC cord-010092-uftc8inx 5098 21 journalists journalist NNS cord-010092-uftc8inx 5098 22 , , , cord-010092-uftc8inx 5098 23 and and CC cord-010092-uftc8inx 5098 24 also also RB cord-010092-uftc8inx 5098 25 in in IN cord-010092-uftc8inx 5098 26 three three CD cord-010092-uftc8inx 5098 27 television television NN cord-010092-uftc8inx 5098 28 stations station NNS cord-010092-uftc8inx 5098 29 with with IN cord-010092-uftc8inx 5098 30 national national JJ cord-010092-uftc8inx 5098 31 broadcast broadcast NN cord-010092-uftc8inx 5098 32 , , , cord-010092-uftc8inx 5098 33 reaching reach VBG cord-010092-uftc8inx 5098 34 millions million NNS cord-010092-uftc8inx 5098 35 of of IN cord-010092-uftc8inx 5098 36 people people NNS cord-010092-uftc8inx 5098 37 . . . cord-010092-uftc8inx 5099 1 Celebrities celebrity NNS cord-010092-uftc8inx 5099 2 ( ( -LRB- cord-010092-uftc8inx 5099 3 sport sport NN cord-010092-uftc8inx 5099 4 , , , cord-010092-uftc8inx 5099 5 television television NN cord-010092-uftc8inx 5099 6 , , , cord-010092-uftc8inx 5099 7 music music NN cord-010092-uftc8inx 5099 8 , , , cord-010092-uftc8inx 5099 9 stand stand VB cord-010092-uftc8inx 5099 10 - - HYPH cord-010092-uftc8inx 5099 11 up up RP cord-010092-uftc8inx 5099 12 comedy comedy NN cord-010092-uftc8inx 5099 13 , , , cord-010092-uftc8inx 5099 14 journalists journalist NNS cord-010092-uftc8inx 5099 15 and and CC cord-010092-uftc8inx 5099 16 a a DT cord-010092-uftc8inx 5099 17 magician magician NN cord-010092-uftc8inx 5099 18 ) ) -RRB- cord-010092-uftc8inx 5099 19 have have VBP cord-010092-uftc8inx 5099 20 accepted accept VBN cord-010092-uftc8inx 5099 21 our -PRON- PRP$ cord-010092-uftc8inx 5099 22 challenge challenge NN cord-010092-uftc8inx 5099 23 through through IN cord-010092-uftc8inx 5099 24 videos video NNS cord-010092-uftc8inx 5099 25 or or CC cord-010092-uftc8inx 5099 26 donating donate VBG cord-010092-uftc8inx 5099 27 blood blood NN cord-010092-uftc8inx 5099 28 , , , cord-010092-uftc8inx 5099 29 appealing appeal VBG cord-010092-uftc8inx 5099 30 to to IN cord-010092-uftc8inx 5099 31 blood blood NN cord-010092-uftc8inx 5099 32 donation donation NN cord-010092-uftc8inx 5099 33 and and CC cord-010092-uftc8inx 5099 34 sponsoring sponsor VBG cord-010092-uftc8inx 5099 35 our -PRON- PRP$ cord-010092-uftc8inx 5099 36 cause cause NN cord-010092-uftc8inx 5099 37 . . . cord-010092-uftc8inx 5100 1 These these DT cord-010092-uftc8inx 5100 2 projects project NNS cord-010092-uftc8inx 5100 3 and and CC cord-010092-uftc8inx 5100 4 continuous continuous JJ cord-010092-uftc8inx 5100 5 availability availability NN cord-010092-uftc8inx 5100 6 to to TO cord-010092-uftc8inx 5100 7 innovate innovate VB cord-010092-uftc8inx 5100 8 have have VB cord-010092-uftc8inx 5100 9 given give VBN cord-010092-uftc8inx 5100 10 our -PRON- PRP$ cord-010092-uftc8inx 5100 11 hospital hospital NN cord-010092-uftc8inx 5100 12 a a DT cord-010092-uftc8inx 5100 13 self self NN cord-010092-uftc8inx 5100 14 - - HYPH cord-010092-uftc8inx 5100 15 sufficiency sufficiency NN cord-010092-uftc8inx 5100 16 of of IN cord-010092-uftc8inx 5100 17 95 95 CD cord-010092-uftc8inx 5100 18 % % NN cord-010092-uftc8inx 5100 19 in in IN cord-010092-uftc8inx 5100 20 2018 2018 CD cord-010092-uftc8inx 5100 21 , , , cord-010092-uftc8inx 5100 22 instead instead RB cord-010092-uftc8inx 5100 23 of of IN cord-010092-uftc8inx 5100 24 80 80 CD cord-010092-uftc8inx 5100 25 % % NN cord-010092-uftc8inx 5100 26 in in IN cord-010092-uftc8inx 5100 27 2016 2016 CD cord-010092-uftc8inx 5100 28 , , , cord-010092-uftc8inx 5100 29 which which WDT cord-010092-uftc8inx 5100 30 implied imply VBD cord-010092-uftc8inx 5100 31 receiving receive VBG cord-010092-uftc8inx 5100 32 less less JJR cord-010092-uftc8inx 5100 33 blood blood NN cord-010092-uftc8inx 5100 34 unities unity NNS cord-010092-uftc8inx 5100 35 from from IN cord-010092-uftc8inx 5100 36 the the DT cord-010092-uftc8inx 5100 37 national national JJ cord-010092-uftc8inx 5100 38 center center NN cord-010092-uftc8inx 5100 39 of of IN cord-010092-uftc8inx 5100 40 blood blood NN cord-010092-uftc8inx 5100 41 supply supply NN cord-010092-uftc8inx 5100 42 . . . cord-010092-uftc8inx 5101 1 Our -PRON- PRP$ cord-010092-uftc8inx 5101 2 most most RBS cord-010092-uftc8inx 5101 3 recent recent JJ cord-010092-uftc8inx 5101 4 project project NN cord-010092-uftc8inx 5101 5 involves involve VBZ cord-010092-uftc8inx 5101 6 high high JJ cord-010092-uftc8inx 5101 7 schools school NNS cord-010092-uftc8inx 5101 8 , , , cord-010092-uftc8inx 5101 9 in in IN cord-010092-uftc8inx 5101 10 an an DT cord-010092-uftc8inx 5101 11 attempt attempt NN cord-010092-uftc8inx 5101 12 to to TO cord-010092-uftc8inx 5101 13 educate educate VB cord-010092-uftc8inx 5101 14 our -PRON- PRP$ cord-010092-uftc8inx 5101 15 next next JJ cord-010092-uftc8inx 5101 16 generation generation NN cord-010092-uftc8inx 5101 17 of of IN cord-010092-uftc8inx 5101 18 donors donor NNS cord-010092-uftc8inx 5101 19 , , , cord-010092-uftc8inx 5101 20 with with IN cord-010092-uftc8inx 5101 21 meetings meeting NNS cord-010092-uftc8inx 5101 22 in in IN cord-010092-uftc8inx 5101 23 the the DT cord-010092-uftc8inx 5101 24 town town NN cord-010092-uftc8inx 5101 25 hall hall NN cord-010092-uftc8inx 5101 26 with with IN cord-010092-uftc8inx 5101 27 deputies deputy NNS cord-010092-uftc8inx 5101 28 and and CC cord-010092-uftc8inx 5101 29 district district NN cord-010092-uftc8inx 5101 30 school school NN cord-010092-uftc8inx 5101 31 delegates delegate NNS cord-010092-uftc8inx 5101 32 . . . cord-010092-uftc8inx 5102 1 Summary Summary NNP cord-010092-uftc8inx 5102 2 / / SYM cord-010092-uftc8inx 5102 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 5102 4 : : : cord-010092-uftc8inx 5103 1 The the DT cord-010092-uftc8inx 5103 2 aging age VBG cord-010092-uftc8inx 5103 3 population population NN cord-010092-uftc8inx 5103 4 and and CC cord-010092-uftc8inx 5103 5 the the DT cord-010092-uftc8inx 5103 6 low low JJ cord-010092-uftc8inx 5103 7 percentage percentage NN cord-010092-uftc8inx 5103 8 of of IN cord-010092-uftc8inx 5103 9 blood blood NN cord-010092-uftc8inx 5103 10 donors donor NNS cord-010092-uftc8inx 5103 11 are be VBP cord-010092-uftc8inx 5103 12 an an DT cord-010092-uftc8inx 5103 13 important important JJ cord-010092-uftc8inx 5103 14 issue issue NN cord-010092-uftc8inx 5103 15 concerning concern VBG cord-010092-uftc8inx 5103 16 public public JJ cord-010092-uftc8inx 5103 17 health health NN cord-010092-uftc8inx 5103 18 . . . cord-010092-uftc8inx 5104 1 Nevertheless nevertheless RB cord-010092-uftc8inx 5104 2 , , , cord-010092-uftc8inx 5104 3 the the DT cord-010092-uftc8inx 5104 4 good good JJ cord-010092-uftc8inx 5104 5 will will NN cord-010092-uftc8inx 5104 6 and and CC cord-010092-uftc8inx 5104 7 continuous continuous JJ cord-010092-uftc8inx 5104 8 advertising advertising NN cord-010092-uftc8inx 5104 9 and and CC cord-010092-uftc8inx 5104 10 educative educative JJ cord-010092-uftc8inx 5104 11 work work NN cord-010092-uftc8inx 5104 12 towards towards IN cord-010092-uftc8inx 5104 13 the the DT cord-010092-uftc8inx 5104 14 population population NN cord-010092-uftc8inx 5104 15 , , , cord-010092-uftc8inx 5104 16 appealing appeal VBG cord-010092-uftc8inx 5104 17 to to IN cord-010092-uftc8inx 5104 18 the the DT cord-010092-uftc8inx 5104 19 ethical ethical JJ cord-010092-uftc8inx 5104 20 and and CC cord-010092-uftc8inx 5104 21 civil civil JJ cord-010092-uftc8inx 5104 22 responsibility responsibility NN cord-010092-uftc8inx 5104 23 since since IN cord-010092-uftc8inx 5104 24 young young JJ cord-010092-uftc8inx 5104 25 ages age NNS cord-010092-uftc8inx 5104 26 have have VBP cord-010092-uftc8inx 5104 27 shown show VBN cord-010092-uftc8inx 5104 28 to to TO cord-010092-uftc8inx 5104 29 improve improve VB cord-010092-uftc8inx 5104 30 our -PRON- PRP$ cord-010092-uftc8inx 5104 31 capacity capacity NN cord-010092-uftc8inx 5104 32 of of IN cord-010092-uftc8inx 5104 33 response response NN cord-010092-uftc8inx 5104 34 as as IN cord-010092-uftc8inx 5104 35 a a DT cord-010092-uftc8inx 5104 36 central central JJ cord-010092-uftc8inx 5104 37 hospital hospital NN cord-010092-uftc8inx 5104 38 , , , cord-010092-uftc8inx 5104 39 increasing increase VBG cord-010092-uftc8inx 5104 40 the the DT cord-010092-uftc8inx 5104 41 auto auto NN cord-010092-uftc8inx 5104 42 - - HYPH cord-010092-uftc8inx 5104 43 sufficiency sufficiency NN cord-010092-uftc8inx 5104 44 of of IN cord-010092-uftc8inx 5104 45 blood blood NN cord-010092-uftc8inx 5104 46 unities unity NNS cord-010092-uftc8inx 5104 47 and and CC cord-010092-uftc8inx 5104 48 the the DT cord-010092-uftc8inx 5104 49 interest interest NN cord-010092-uftc8inx 5104 50 of of IN cord-010092-uftc8inx 5104 51 younger young JJR cord-010092-uftc8inx 5104 52 donors donor NNS cord-010092-uftc8inx 5104 53 . . . cord-010092-uftc8inx 5105 1 It -PRON- PRP cord-010092-uftc8inx 5105 2 is be VBZ cord-010092-uftc8inx 5105 3 of of IN cord-010092-uftc8inx 5105 4 the the DT cord-010092-uftc8inx 5105 5 utmost utmost JJ cord-010092-uftc8inx 5105 6 importance importance NN cord-010092-uftc8inx 5105 7 to to TO cord-010092-uftc8inx 5105 8 understand understand VB cord-010092-uftc8inx 5105 9 that that IN cord-010092-uftc8inx 5105 10 this this DT cord-010092-uftc8inx 5105 11 is be VBZ cord-010092-uftc8inx 5105 12 a a DT cord-010092-uftc8inx 5105 13 continuous continuous JJ cord-010092-uftc8inx 5105 14 and and CC cord-010092-uftc8inx 5105 15 a a DT cord-010092-uftc8inx 5105 16 hard hard JJ cord-010092-uftc8inx 5105 17 work work NN cord-010092-uftc8inx 5105 18 of of IN cord-010092-uftc8inx 5105 19 the the DT cord-010092-uftc8inx 5105 20 professional professional JJ cord-010092-uftc8inx 5105 21 team team NN cord-010092-uftc8inx 5105 22 of of IN cord-010092-uftc8inx 5105 23 our -PRON- PRP$ cord-010092-uftc8inx 5105 24 hospital hospital NN cord-010092-uftc8inx 5105 25 , , , cord-010092-uftc8inx 5105 26 involving involve VBG cord-010092-uftc8inx 5105 27 countless countless JJ cord-010092-uftc8inx 5105 28 calls call NNS cord-010092-uftc8inx 5105 29 , , , cord-010092-uftc8inx 5105 30 emails email NNS cord-010092-uftc8inx 5105 31 and and CC cord-010092-uftc8inx 5105 32 hours hour NNS cord-010092-uftc8inx 5105 33 to to TO cord-010092-uftc8inx 5105 34 obtain obtain VB cord-010092-uftc8inx 5105 35 some some DT cord-010092-uftc8inx 5105 36 positive positive JJ cord-010092-uftc8inx 5105 37 response response NN cord-010092-uftc8inx 5105 38 , , , cord-010092-uftc8inx 5105 39 in in IN cord-010092-uftc8inx 5105 40 an an DT cord-010092-uftc8inx 5105 41 endless endless JJ cord-010092-uftc8inx 5105 42 job job NN cord-010092-uftc8inx 5105 43 . . . cord-010092-uftc8inx 5106 1 [ [ -LRB- cord-010092-uftc8inx 5106 2 1 1 CD cord-010092-uftc8inx 5106 3 ] ] -RRB- cord-010092-uftc8inx 5106 4 [ [ -LRB- cord-010092-uftc8inx 5106 5 2 2 CD cord-010092-uftc8inx 5106 6 ] ] -RRB- cord-010092-uftc8inx 5106 7 [ [ -LRB- cord-010092-uftc8inx 5106 8 3 3 CD cord-010092-uftc8inx 5106 9 ] ] -RRB- cord-010092-uftc8inx 5106 10 [ [ -LRB- cord-010092-uftc8inx 5106 11 4 4 CD cord-010092-uftc8inx 5106 12 ] ] -RRB- cord-010092-uftc8inx 5106 13 [ [ -LRB- cord-010092-uftc8inx 5106 14 5 5 CD cord-010092-uftc8inx 5106 15 ] ] -RRB- cord-010092-uftc8inx 5106 16 [ [ -LRB- cord-010092-uftc8inx 5106 17 6 6 CD cord-010092-uftc8inx 5106 18 ] ] -RRB- cord-010092-uftc8inx 5106 19 [ [ -LRB- cord-010092-uftc8inx 5106 20 7 7 CD cord-010092-uftc8inx 5106 21 ] ] -RRB- cord-010092-uftc8inx 5107 1 [ [ -LRB- cord-010092-uftc8inx 5107 2 8 8 CD cord-010092-uftc8inx 5107 3 ] ] -RRB- cord-010092-uftc8inx 5107 4 [ [ -LRB- cord-010092-uftc8inx 5107 5 9 9 CD cord-010092-uftc8inx 5107 6 ] ] -RRB- cord-010092-uftc8inx 5107 7 [ [ -LRB- cord-010092-uftc8inx 5107 8 10 10 CD cord-010092-uftc8inx 5107 9 ] ] -RRB- cord-010092-uftc8inx 5108 1 [ [ -LRB- cord-010092-uftc8inx 5108 2 11 11 CD cord-010092-uftc8inx 5108 3 ] ] -RRB- cord-010092-uftc8inx 5108 4 [ [ -LRB- cord-010092-uftc8inx 5108 5 12 12 CD cord-010092-uftc8inx 5108 6 ] ] -RRB- cord-010092-uftc8inx 5108 7 . . . cord-010092-uftc8inx 5109 1 The the DT cord-010092-uftc8inx 5109 2 mean mean JJ cord-010092-uftc8inx 5109 3 interval interval NN cord-010092-uftc8inx 5109 4 between between IN cord-010092-uftc8inx 5109 5 donations donation NNS cord-010092-uftc8inx 5109 6 is be VBZ cord-010092-uftc8inx 5109 7 shorter short JJR cord-010092-uftc8inx 5109 8 for for IN cord-010092-uftc8inx 5109 9 former former JJ cord-010092-uftc8inx 5109 10 regular regular JJ cord-010092-uftc8inx 5109 11 donors donor NNS cord-010092-uftc8inx 5109 12 ( ( -LRB- cord-010092-uftc8inx 5109 13 4.9 4.9 CD cord-010092-uftc8inx 5109 14 months month NNS cord-010092-uftc8inx 5109 15 , , , cord-010092-uftc8inx 5109 16 P p NN cord-010092-uftc8inx 5109 17 < < XX cord-010092-uftc8inx 5109 18 0.01 0.01 CD cord-010092-uftc8inx 5109 19 ) ) -RRB- cord-010092-uftc8inx 5109 20 whereas whereas IN cord-010092-uftc8inx 5109 21 donors donor NNS cord-010092-uftc8inx 5109 22 with with IN cord-010092-uftc8inx 5109 23 an an DT cord-010092-uftc8inx 5109 24 interval interval NN cord-010092-uftc8inx 5109 25 of of IN cord-010092-uftc8inx 5109 26 9 9 CD cord-010092-uftc8inx 5109 27 to to TO cord-010092-uftc8inx 5109 28 12 12 CD cord-010092-uftc8inx 5109 29 months month NNS cord-010092-uftc8inx 5109 30 are be VBP cord-010092-uftc8inx 5109 31 more more RBR cord-010092-uftc8inx 5109 32 likely likely JJ cord-010092-uftc8inx 5109 33 to to TO cord-010092-uftc8inx 5109 34 be be VB cord-010092-uftc8inx 5109 35 regular regular JJ cord-010092-uftc8inx 5109 36 ( ( -LRB- cord-010092-uftc8inx 5109 37 aOR aor NN cord-010092-uftc8inx 5109 38 16 16 CD cord-010092-uftc8inx 5109 39 ; ; : cord-010092-uftc8inx 5109 40 95 95 CD cord-010092-uftc8inx 5109 41 % % NN cord-010092-uftc8inx 5109 42 CI CI NNP cord-010092-uftc8inx 5109 43 1.6 1.6 CD cord-010092-uftc8inx 5109 44 - - SYM cord-010092-uftc8inx 5109 45 164 164 CD cord-010092-uftc8inx 5109 46 ) ) -RRB- cord-010092-uftc8inx 5109 47 . . . cord-010092-uftc8inx 5110 1 Summary Summary NNP cord-010092-uftc8inx 5110 2 / / SYM cord-010092-uftc8inx 5110 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 5110 4 : : : cord-010092-uftc8inx 5111 1 At at IN cord-010092-uftc8inx 5111 2 the the DT cord-010092-uftc8inx 5111 3 Provincial Provincial NNP cord-010092-uftc8inx 5111 4 Blood Blood NNP cord-010092-uftc8inx 5111 5 Transfusion Transfusion NNP cord-010092-uftc8inx 5111 6 Centre Centre NNP cord-010092-uftc8inx 5111 7 of of IN cord-010092-uftc8inx 5111 8 Bukavu Bukavu NNP cord-010092-uftc8inx 5111 9 , , , cord-010092-uftc8inx 5111 10 the the DT cord-010092-uftc8inx 5111 11 percentage percentage NN cord-010092-uftc8inx 5111 12 of of IN cord-010092-uftc8inx 5111 13 regular regular JJ cord-010092-uftc8inx 5111 14 donors donor NNS cord-010092-uftc8inx 5111 15 is be VBZ cord-010092-uftc8inx 5111 16 low low JJ cord-010092-uftc8inx 5111 17 and and CC cord-010092-uftc8inx 5111 18 there there EX cord-010092-uftc8inx 5111 19 is be VBZ cord-010092-uftc8inx 5111 20 a a DT cord-010092-uftc8inx 5111 21 substantial substantial JJ cord-010092-uftc8inx 5111 22 loss loss NN cord-010092-uftc8inx 5111 23 of of IN cord-010092-uftc8inx 5111 24 former former JJ cord-010092-uftc8inx 5111 25 regular regular JJ cord-010092-uftc8inx 5111 26 donors donor NNS cord-010092-uftc8inx 5111 27 . . . cord-010092-uftc8inx 5112 1 Some some DT cord-010092-uftc8inx 5112 2 factors factor NNS cord-010092-uftc8inx 5112 3 identified identify VBN cord-010092-uftc8inx 5112 4 to to TO cord-010092-uftc8inx 5112 5 be be VB cord-010092-uftc8inx 5112 6 linked link VBN cord-010092-uftc8inx 5112 7 to to IN cord-010092-uftc8inx 5112 8 fidelity fidelity NN cord-010092-uftc8inx 5112 9 are be VBP cord-010092-uftc8inx 5112 10 unique unique JJ cord-010092-uftc8inx 5112 11 to to IN cord-010092-uftc8inx 5112 12 our -PRON- PRP$ cord-010092-uftc8inx 5112 13 study study NN cord-010092-uftc8inx 5112 14 : : : cord-010092-uftc8inx 5112 15 female female JJ cord-010092-uftc8inx 5112 16 gender gender NN cord-010092-uftc8inx 5112 17 and and CC cord-010092-uftc8inx 5112 18 a a DT cord-010092-uftc8inx 5112 19 longer long JJR cord-010092-uftc8inx 5112 20 interdonation interdonation NN cord-010092-uftc8inx 5112 21 interval interval NN cord-010092-uftc8inx 5112 22 . . . cord-010092-uftc8inx 5113 1 Other other JJ cord-010092-uftc8inx 5113 2 factors factor NNS cord-010092-uftc8inx 5113 3 that that WDT cord-010092-uftc8inx 5113 4 are be VBP cord-010092-uftc8inx 5113 5 similar similar JJ cord-010092-uftc8inx 5113 6 to to IN cord-010092-uftc8inx 5113 7 those those DT cord-010092-uftc8inx 5113 8 found find VBN cord-010092-uftc8inx 5113 9 elsewhere elsewhere RB cord-010092-uftc8inx 5113 10 have have VBP cord-010092-uftc8inx 5113 11 a a DT cord-010092-uftc8inx 5113 12 particular particular JJ cord-010092-uftc8inx 5113 13 significance significance NN cord-010092-uftc8inx 5113 14 in in IN cord-010092-uftc8inx 5113 15 our -PRON- PRP$ cord-010092-uftc8inx 5113 16 donor donor NN cord-010092-uftc8inx 5113 17 population population NN cord-010092-uftc8inx 5113 18 which which WDT cord-010092-uftc8inx 5113 19 consists consist VBZ cord-010092-uftc8inx 5113 20 mainly mainly RB cord-010092-uftc8inx 5113 21 of of IN cord-010092-uftc8inx 5113 22 young young JJ cord-010092-uftc8inx 5113 23 people people NNS cord-010092-uftc8inx 5113 24 and and CC cord-010092-uftc8inx 5113 25 people people NNS cord-010092-uftc8inx 5113 26 without without IN cord-010092-uftc8inx 5113 27 income income NN cord-010092-uftc8inx 5113 28 . . . cord-010092-uftc8inx 5114 1 Efforts effort NNS cord-010092-uftc8inx 5114 2 must must MD cord-010092-uftc8inx 5114 3 be be VB cord-010092-uftc8inx 5114 4 undertaken undertake VBN cord-010092-uftc8inx 5114 5 to to TO cord-010092-uftc8inx 5114 6 ensure ensure VB cord-010092-uftc8inx 5114 7 a a DT cord-010092-uftc8inx 5114 8 supply supply NN cord-010092-uftc8inx 5114 9 from from IN cord-010092-uftc8inx 5114 10 voluntary voluntary JJ cord-010092-uftc8inx 5114 11 donations donation NNS cord-010092-uftc8inx 5114 12 ; ; : cord-010092-uftc8inx 5114 13 recruitment recruitment NN cord-010092-uftc8inx 5114 14 strategies strategy NNS cord-010092-uftc8inx 5114 15 and and CC cord-010092-uftc8inx 5114 16 target target NN cord-010092-uftc8inx 5114 17 groups group NNS cord-010092-uftc8inx 5114 18 must must MD cord-010092-uftc8inx 5114 19 be be VB cord-010092-uftc8inx 5114 20 refined refine VBN cord-010092-uftc8inx 5114 21 . . . cord-010092-uftc8inx 5115 1 Future future JJ cord-010092-uftc8inx 5115 2 qualitative qualitative JJ cord-010092-uftc8inx 5115 3 studies study NNS cord-010092-uftc8inx 5115 4 are be VBP cord-010092-uftc8inx 5115 5 needed need VBN cord-010092-uftc8inx 5115 6 to to TO cord-010092-uftc8inx 5115 7 explain explain VB cord-010092-uftc8inx 5115 8 the the DT cord-010092-uftc8inx 5115 9 various various JJ cord-010092-uftc8inx 5115 10 associated associate VBN cord-010092-uftc8inx 5115 11 factors factor NNS cord-010092-uftc8inx 5115 12 and and CC cord-010092-uftc8inx 5115 13 better well RBR cord-010092-uftc8inx 5115 14 understand understand VB cord-010092-uftc8inx 5115 15 the the DT cord-010092-uftc8inx 5115 16 motivations motivation NNS cord-010092-uftc8inx 5115 17 of of IN cord-010092-uftc8inx 5115 18 regular regular JJ cord-010092-uftc8inx 5115 19 and and CC cord-010092-uftc8inx 5115 20 non non JJ cord-010092-uftc8inx 5115 21 - - JJ cord-010092-uftc8inx 5115 22 regular regular JJ cord-010092-uftc8inx 5115 23 donors donor NNS cord-010092-uftc8inx 5115 24 to to TO cord-010092-uftc8inx 5115 25 improve improve VB cord-010092-uftc8inx 5115 26 donor donor NN cord-010092-uftc8inx 5115 27 retention retention NN cord-010092-uftc8inx 5115 28 . . . cord-010092-uftc8inx 5116 1 Results result NNS cord-010092-uftc8inx 5116 2 : : : cord-010092-uftc8inx 5117 1 In in IN cord-010092-uftc8inx 5117 2 Kazakhstan Kazakhstan NNP cord-010092-uftc8inx 5117 3 , , , cord-010092-uftc8inx 5117 4 the the DT cord-010092-uftc8inx 5117 5 proportion proportion NN cord-010092-uftc8inx 5117 6 of of IN cord-010092-uftc8inx 5117 7 donors donor NNS cord-010092-uftc8inx 5117 8 is be VBZ cord-010092-uftc8inx 5117 9 higher high JJR cord-010092-uftc8inx 5117 10 , , , cord-010092-uftc8inx 5117 11 especially especially RB cord-010092-uftc8inx 5117 12 primary primary JJ cord-010092-uftc8inx 5117 13 . . . cord-010092-uftc8inx 5118 1 The the DT cord-010092-uftc8inx 5118 2 number number NN cord-010092-uftc8inx 5118 3 of of IN cord-010092-uftc8inx 5118 4 blood blood NN cord-010092-uftc8inx 5118 5 and and CC cord-010092-uftc8inx 5118 6 especially especially RB cord-010092-uftc8inx 5118 7 plasma plasma NN cord-010092-uftc8inx 5118 8 donations donation NNS cord-010092-uftc8inx 5118 9 is be VBZ cord-010092-uftc8inx 5118 10 higher high JJR cord-010092-uftc8inx 5118 11 , , , cord-010092-uftc8inx 5118 12 which which WDT cord-010092-uftc8inx 5118 13 can can MD cord-010092-uftc8inx 5118 14 be be VB cord-010092-uftc8inx 5118 15 explained explain VBN cord-010092-uftc8inx 5118 16 by by IN cord-010092-uftc8inx 5118 17 the the DT cord-010092-uftc8inx 5118 18 presence presence NN cord-010092-uftc8inx 5118 19 of of IN cord-010092-uftc8inx 5118 20 several several JJ cord-010092-uftc8inx 5118 21 albumin albumin NN cord-010092-uftc8inx 5118 22 and and CC cord-010092-uftc8inx 5118 23 immunoglobulin immunoglobulin NN cord-010092-uftc8inx 5118 24 production production NN cord-010092-uftc8inx 5118 25 sites site NNS cord-010092-uftc8inx 5118 26 . . . cord-010092-uftc8inx 5119 1 Increased increase VBN cord-010092-uftc8inx 5119 2 evidence evidence NN cord-010092-uftc8inx 5119 3 of of IN cord-010092-uftc8inx 5119 4 blood blood NN cord-010092-uftc8inx 5119 5 transfusion transfusion NN cord-010092-uftc8inx 5119 6 rules rule NNS cord-010092-uftc8inx 5119 7 , , , cord-010092-uftc8inx 5119 8 the the DT cord-010092-uftc8inx 5119 9 development development NN cord-010092-uftc8inx 5119 10 of of IN cord-010092-uftc8inx 5119 11 a a DT cord-010092-uftc8inx 5119 12 patient patient NN cord-010092-uftc8inx 5119 13 's 's POS cord-010092-uftc8inx 5119 14 blood blood NN cord-010092-uftc8inx 5119 15 management management NN cord-010092-uftc8inx 5119 16 in in IN cord-010092-uftc8inx 5119 17 combination combination NN cord-010092-uftc8inx 5119 18 with with IN cord-010092-uftc8inx 5119 19 an an DT cord-010092-uftc8inx 5119 20 increase increase NN cord-010092-uftc8inx 5119 21 in in IN cord-010092-uftc8inx 5119 22 the the DT cord-010092-uftc8inx 5119 23 quality quality NN cord-010092-uftc8inx 5119 24 of of IN cord-010092-uftc8inx 5119 25 blood blood NN cord-010092-uftc8inx 5119 26 components component NNS cord-010092-uftc8inx 5119 27 cause cause VBP cord-010092-uftc8inx 5119 28 a a DT cord-010092-uftc8inx 5119 29 reduction reduction NN cord-010092-uftc8inx 5119 30 in in IN cord-010092-uftc8inx 5119 31 clinical clinical JJ cord-010092-uftc8inx 5119 32 need need NN cord-010092-uftc8inx 5119 33 for for IN cord-010092-uftc8inx 5119 34 red red JJ cord-010092-uftc8inx 5119 35 blood blood NN cord-010092-uftc8inx 5119 36 cells cell NNS cord-010092-uftc8inx 5119 37 and and CC cord-010092-uftc8inx 5119 38 plasma plasma NN cord-010092-uftc8inx 5119 39 for for IN cord-010092-uftc8inx 5119 40 transfusion transfusion NN cord-010092-uftc8inx 5119 41 . . . cord-010092-uftc8inx 5120 1 At at IN cord-010092-uftc8inx 5120 2 the the DT cord-010092-uftc8inx 5120 3 same same JJ cord-010092-uftc8inx 5120 4 time time NN cord-010092-uftc8inx 5120 5 , , , cord-010092-uftc8inx 5120 6 the the DT cord-010092-uftc8inx 5120 7 need need NN cord-010092-uftc8inx 5120 8 for for IN cord-010092-uftc8inx 5120 9 platelets platelet NNS cord-010092-uftc8inx 5120 10 is be VBZ cord-010092-uftc8inx 5120 11 growing grow VBG cord-010092-uftc8inx 5120 12 . . . cord-010092-uftc8inx 5121 1 It -PRON- PRP cord-010092-uftc8inx 5121 2 is be VBZ cord-010092-uftc8inx 5121 3 difficult difficult JJ cord-010092-uftc8inx 5121 4 to to TO cord-010092-uftc8inx 5121 5 assess assess VB cord-010092-uftc8inx 5121 6 the the DT cord-010092-uftc8inx 5121 7 correctness correctness NN cord-010092-uftc8inx 5121 8 of of IN cord-010092-uftc8inx 5121 9 comparing compare VBG cord-010092-uftc8inx 5121 10 the the DT cord-010092-uftc8inx 5121 11 amount amount NN cord-010092-uftc8inx 5121 12 of of IN cord-010092-uftc8inx 5121 13 banked bank VBN cord-010092-uftc8inx 5121 14 whole whole JJ cord-010092-uftc8inx 5121 15 blood blood NN cord-010092-uftc8inx 5121 16 . . . cord-010092-uftc8inx 5122 1 It -PRON- PRP cord-010092-uftc8inx 5122 2 is be VBZ cord-010092-uftc8inx 5122 3 equally equally RB cord-010092-uftc8inx 5122 4 difficult difficult JJ cord-010092-uftc8inx 5122 5 to to TO cord-010092-uftc8inx 5122 6 compare compare VB cord-010092-uftc8inx 5122 7 the the DT cord-010092-uftc8inx 5122 8 number number NN cord-010092-uftc8inx 5122 9 of of IN cord-010092-uftc8inx 5122 10 received receive VBN cord-010092-uftc8inx 5122 11 and and CC cord-010092-uftc8inx 5122 12 distributed distribute VBN cord-010092-uftc8inx 5122 13 donor donor NN cord-010092-uftc8inx 5122 14 red red JJ cord-010092-uftc8inx 5122 15 blood blood NN cord-010092-uftc8inx 5122 16 cells cell NNS cord-010092-uftc8inx 5122 17 and and CC cord-010092-uftc8inx 5122 18 plasma plasma NN cord-010092-uftc8inx 5122 19 : : : cord-010092-uftc8inx 5123 1 in in IN cord-010092-uftc8inx 5123 2 Russia Russia NNP cord-010092-uftc8inx 5123 3 they -PRON- PRP cord-010092-uftc8inx 5123 4 are be VBP cord-010092-uftc8inx 5123 5 measured measure VBN cord-010092-uftc8inx 5123 6 in in IN cord-010092-uftc8inx 5123 7 liters liter NNS cord-010092-uftc8inx 5123 8 , , , cord-010092-uftc8inx 5123 9 and and CC cord-010092-uftc8inx 5123 10 in in IN cord-010092-uftc8inx 5123 11 Kazakhstan Kazakhstan NNP cord-010092-uftc8inx 5123 12 in in IN cord-010092-uftc8inx 5123 13 doses dose NNS cord-010092-uftc8inx 5123 14 . . . cord-010092-uftc8inx 5124 1 With with IN cord-010092-uftc8inx 5124 2 a a DT cord-010092-uftc8inx 5124 3 certain certain JJ cord-010092-uftc8inx 5124 4 degree degree NN cord-010092-uftc8inx 5124 5 of of IN cord-010092-uftc8inx 5124 6 conditionality conditionality NN cord-010092-uftc8inx 5124 7 platelet platelet NN cord-010092-uftc8inx 5124 8 extraction extraction NN cord-010092-uftc8inx 5124 9 can can MD cord-010092-uftc8inx 5124 10 be be VB cord-010092-uftc8inx 5124 11 compared compare VBN cord-010092-uftc8inx 5124 12 . . . cord-010092-uftc8inx 5125 1 In in IN cord-010092-uftc8inx 5125 2 Russia Russia NNP cord-010092-uftc8inx 5125 3 , , , cord-010092-uftc8inx 5125 4 they -PRON- PRP cord-010092-uftc8inx 5125 5 are be VBP cord-010092-uftc8inx 5125 6 counted count VBN cord-010092-uftc8inx 5125 7 in in IN cord-010092-uftc8inx 5125 8 equivalent equivalent JJ cord-010092-uftc8inx 5125 9 doses dose NNS cord-010092-uftc8inx 5125 10 isolated isolate VBN cord-010092-uftc8inx 5125 11 from from IN cord-010092-uftc8inx 5125 12 a a DT cord-010092-uftc8inx 5125 13 dose dose NN cord-010092-uftc8inx 5125 14 of of IN cord-010092-uftc8inx 5125 15 whole whole JJ cord-010092-uftc8inx 5125 16 blood blood NN cord-010092-uftc8inx 5125 17 ( ( -LRB- cord-010092-uftc8inx 5125 18 at at RB cord-010092-uftc8inx 5125 19 least least JJS cord-010092-uftc8inx 5125 20 60 60 CD cord-010092-uftc8inx 5125 21 9 9 CD cord-010092-uftc8inx 5125 22 10 10 CD cord-010092-uftc8inx 5125 23 9 9 CD cord-010092-uftc8inx 5125 24 cells cell NNS cord-010092-uftc8inx 5125 25 per per IN cord-010092-uftc8inx 5125 26 dose dose NN cord-010092-uftc8inx 5125 27 ) ) -RRB- cord-010092-uftc8inx 5125 28 , , , cord-010092-uftc8inx 5125 29 and and CC cord-010092-uftc8inx 5125 30 in in IN cord-010092-uftc8inx 5125 31 Kazakhstanin Kazakhstanin NNP cord-010092-uftc8inx 5125 32 therapeutic therapeutic JJ cord-010092-uftc8inx 5125 33 doses dose NNS cord-010092-uftc8inx 5125 34 ( ( -LRB- cord-010092-uftc8inx 5125 35 at at RB cord-010092-uftc8inx 5125 36 least least RBS cord-010092-uftc8inx 5125 37 200 200 CD cord-010092-uftc8inx 5125 38 9 9 CD cord-010092-uftc8inx 5125 39 10 10 CD cord-010092-uftc8inx 5125 40 9 9 CD cord-010092-uftc8inx 5125 41 cells cell NNS cord-010092-uftc8inx 5125 42 per per IN cord-010092-uftc8inx 5125 43 dose dose NN cord-010092-uftc8inx 5125 44 ) ) -RRB- cord-010092-uftc8inx 5125 45 . . . cord-010092-uftc8inx 5126 1 In in IN cord-010092-uftc8inx 5126 2 2017 2017 CD cord-010092-uftc8inx 5126 3 , , , cord-010092-uftc8inx 5126 4 the the DT cord-010092-uftc8inx 5126 5 estimated estimate VBN cord-010092-uftc8inx 5126 6 consumption consumption NN cord-010092-uftc8inx 5126 7 of of IN cord-010092-uftc8inx 5126 8 platelets platelet NNS cord-010092-uftc8inx 5126 9 in in IN cord-010092-uftc8inx 5126 10 Kazakhstan Kazakhstan NNP cord-010092-uftc8inx 5126 11 exceeded exceed VBD cord-010092-uftc8inx 5126 12 the the DT cord-010092-uftc8inx 5126 13 Russian russian JJ cord-010092-uftc8inx 5126 14 indicator indicator NN cord-010092-uftc8inx 5126 15 by by IN cord-010092-uftc8inx 5126 16 28.0 28.0 CD cord-010092-uftc8inx 5126 17 % % NN cord-010092-uftc8inx 5126 18 . . . cord-010092-uftc8inx 5127 1 86 86 CD cord-010092-uftc8inx 5127 2 % % NN cord-010092-uftc8inx 5127 3 of of IN cord-010092-uftc8inx 5127 4 platelets platelet NNS cord-010092-uftc8inx 5127 5 in in IN cord-010092-uftc8inx 5127 6 Kazakhstan Kazakhstan NNP cord-010092-uftc8inx 5127 7 and and CC cord-010092-uftc8inx 5127 8 69.9 69.9 CD cord-010092-uftc8inx 5127 9 % % NN cord-010092-uftc8inx 5127 10 in in IN cord-010092-uftc8inx 5127 11 Russia Russia NNP cord-010092-uftc8inx 5127 12 are be VBP cord-010092-uftc8inx 5127 13 harvested harvest VBN cord-010092-uftc8inx 5127 14 by by IN cord-010092-uftc8inx 5127 15 the the DT cord-010092-uftc8inx 5127 16 apheresis apheresis NN cord-010092-uftc8inx 5127 17 method method NN cord-010092-uftc8inx 5127 18 . . . cord-010092-uftc8inx 5128 1 Inactivation inactivation NN cord-010092-uftc8inx 5128 2 of of IN cord-010092-uftc8inx 5128 3 pathogens pathogen NNS cord-010092-uftc8inx 5128 4 is be VBZ cord-010092-uftc8inx 5128 5 performed perform VBN cord-010092-uftc8inx 5128 6 in in IN cord-010092-uftc8inx 5128 7 92 92 CD cord-010092-uftc8inx 5128 8 % % NN cord-010092-uftc8inx 5128 9 of of IN cord-010092-uftc8inx 5128 10 platelets platelet NNS cord-010092-uftc8inx 5128 11 in in IN cord-010092-uftc8inx 5128 12 Kazakhstan Kazakhstan NNP cord-010092-uftc8inx 5128 13 and and CC cord-010092-uftc8inx 5128 14 in in IN cord-010092-uftc8inx 5128 15 15.4 15.4 CD cord-010092-uftc8inx 5128 16 % % NN cord-010092-uftc8inx 5128 17 in in IN cord-010092-uftc8inx 5128 18 Russia Russia NNP cord-010092-uftc8inx 5128 19 . . . cord-010092-uftc8inx 5129 1 Pathogen pathogen NN cord-010092-uftc8inx 5129 2 inactivation inactivation NN cord-010092-uftc8inx 5129 3 with with IN cord-010092-uftc8inx 5129 4 amotosalen amotosalen NNP cord-010092-uftc8inx 5129 5 allows allow VBZ cord-010092-uftc8inx 5129 6 us -PRON- PRP cord-010092-uftc8inx 5129 7 to to TO cord-010092-uftc8inx 5129 8 abandon abandon VB cord-010092-uftc8inx 5129 9 the the DT cord-010092-uftc8inx 5129 10 examination examination NN cord-010092-uftc8inx 5129 11 of of IN cord-010092-uftc8inx 5129 12 donors donor NNS cord-010092-uftc8inx 5129 13 for for IN cord-010092-uftc8inx 5129 14 cytomegalovirus cytomegalovirus NN cord-010092-uftc8inx 5129 15 and and CC cord-010092-uftc8inx 5129 16 irradiation irradiation NN cord-010092-uftc8inx 5129 17 of of IN cord-010092-uftc8inx 5129 18 platelet platelet NN cord-010092-uftc8inx 5129 19 concentrate concentrate NN cord-010092-uftc8inx 5129 20 . . . cord-010092-uftc8inx 5130 1 The the DT cord-010092-uftc8inx 5130 2 main main JJ cord-010092-uftc8inx 5130 3 modern modern JJ cord-010092-uftc8inx 5130 4 trend trend NN cord-010092-uftc8inx 5130 5 in in IN cord-010092-uftc8inx 5130 6 the the DT cord-010092-uftc8inx 5130 7 use use NN cord-010092-uftc8inx 5130 8 of of IN cord-010092-uftc8inx 5130 9 cryoprecipitate cryoprecipitate NNP cord-010092-uftc8inx 5130 10 is be VBZ cord-010092-uftc8inx 5130 11 using use VBG cord-010092-uftc8inx 5130 12 it -PRON- PRP cord-010092-uftc8inx 5130 13 as as IN cord-010092-uftc8inx 5130 14 a a DT cord-010092-uftc8inx 5130 15 source source NN cord-010092-uftc8inx 5130 16 of of IN cord-010092-uftc8inx 5130 17 fibrinogen fibrinogen NN cord-010092-uftc8inx 5130 18 , , , cord-010092-uftc8inx 5130 19 a a DT cord-010092-uftc8inx 5130 20 blood blood NN cord-010092-uftc8inx 5130 21 coagulation coagulation NN cord-010092-uftc8inx 5130 22 factor factor NN cord-010092-uftc8inx 5130 23 that that WDT cord-010092-uftc8inx 5130 24 is be VBZ cord-010092-uftc8inx 5130 25 first first RB cord-010092-uftc8inx 5130 26 depleted deplete VBN cord-010092-uftc8inx 5130 27 in in IN cord-010092-uftc8inx 5130 28 coagulopathy coagulopathy NN cord-010092-uftc8inx 5130 29 associated associate VBN cord-010092-uftc8inx 5130 30 with with IN cord-010092-uftc8inx 5130 31 injury injury NN cord-010092-uftc8inx 5130 32 and and CC cord-010092-uftc8inx 5130 33 massive massive JJ cord-010092-uftc8inx 5130 34 bleeding bleeding NN cord-010092-uftc8inx 5130 35 . . . cord-010092-uftc8inx 5131 1 Its -PRON- PRP$ cord-010092-uftc8inx 5131 2 production production NN cord-010092-uftc8inx 5131 3 is be VBZ cord-010092-uftc8inx 5131 4 growing grow VBG cord-010092-uftc8inx 5131 5 in in IN cord-010092-uftc8inx 5131 6 both both DT cord-010092-uftc8inx 5131 7 countries country NNS cord-010092-uftc8inx 5131 8 , , , cord-010092-uftc8inx 5131 9 endowment endowment NN cord-010092-uftc8inx 5131 10 in in IN cord-010092-uftc8inx 5131 11 Kazakhstan Kazakhstan NNP cord-010092-uftc8inx 5131 12 in in IN cord-010092-uftc8inx 5131 13 2017 2017 CD cord-010092-uftc8inx 5131 14 exceeded exceed VBD cord-010092-uftc8inx 5131 15 the the DT cord-010092-uftc8inx 5131 16 Russian russian JJ cord-010092-uftc8inx 5131 17 indicator indicator NN cord-010092-uftc8inx 5131 18 by by IN cord-010092-uftc8inx 5131 19 141.4 141.4 CD cord-010092-uftc8inx 5131 20 % % NN cord-010092-uftc8inx 5131 21 . . . cord-010092-uftc8inx 5132 1 A a DT cord-010092-uftc8inx 5132 2 significant significant JJ cord-010092-uftc8inx 5132 3 plasma plasma NN cord-010092-uftc8inx 5132 4 percentage percentage NN cord-010092-uftc8inx 5132 5 in in IN cord-010092-uftc8inx 5132 6 both both DT cord-010092-uftc8inx 5132 7 countries country NNS cord-010092-uftc8inx 5132 8 does do VBZ cord-010092-uftc8inx 5132 9 not not RB cord-010092-uftc8inx 5132 10 pass pass VB cord-010092-uftc8inx 5132 11 quarantine quarantine NN cord-010092-uftc8inx 5132 12 due due JJ cord-010092-uftc8inx 5132 13 to to IN cord-010092-uftc8inx 5132 14 repeated repeat VBN cord-010092-uftc8inx 5132 15 non non JJ cord-010092-uftc8inx 5132 16 - - JJ cord-010092-uftc8inx 5132 17 appearance appearance NN cord-010092-uftc8inx 5132 18 of of IN cord-010092-uftc8inx 5132 19 the the DT cord-010092-uftc8inx 5132 20 donor donor NN cord-010092-uftc8inx 5132 21 and and CC cord-010092-uftc8inx 5132 22 is be VBZ cord-010092-uftc8inx 5132 23 subject subject JJ cord-010092-uftc8inx 5132 24 to to IN cord-010092-uftc8inx 5132 25 destruction destruction NN cord-010092-uftc8inx 5132 26 . . . cord-010092-uftc8inx 5133 1 Inactivation inactivation NN cord-010092-uftc8inx 5133 2 of of IN cord-010092-uftc8inx 5133 3 pathogens pathogen NNS cord-010092-uftc8inx 5133 4 is be VBZ cord-010092-uftc8inx 5133 5 performed perform VBN cord-010092-uftc8inx 5133 6 in in IN cord-010092-uftc8inx 5133 7 10 10 CD cord-010092-uftc8inx 5133 8 % % NN cord-010092-uftc8inx 5133 9 of of IN cord-010092-uftc8inx 5133 10 plasma plasma NN cord-010092-uftc8inx 5133 11 in in IN cord-010092-uftc8inx 5133 12 Kazakhstan Kazakhstan NNP cord-010092-uftc8inx 5133 13 and and CC cord-010092-uftc8inx 5133 14 in in IN cord-010092-uftc8inx 5133 15 3.6 3.6 CD cord-010092-uftc8inx 5133 16 % % NN cord-010092-uftc8inx 5133 17 in in IN cord-010092-uftc8inx 5133 18 Russia Russia NNP cord-010092-uftc8inx 5133 19 . . . cord-010092-uftc8inx 5134 1 Despite despite IN cord-010092-uftc8inx 5134 2 the the DT cord-010092-uftc8inx 5134 3 instruction instruction NN cord-010092-uftc8inx 5134 4 and and CC cord-010092-uftc8inx 5134 5 selection selection NN cord-010092-uftc8inx 5134 6 of of IN cord-010092-uftc8inx 5134 7 donors donor NNS cord-010092-uftc8inx 5134 8 , , , cord-010092-uftc8inx 5134 9 laboratory laboratory NN cord-010092-uftc8inx 5134 10 screening screening NN cord-010092-uftc8inx 5134 11 of of IN cord-010092-uftc8inx 5134 12 infection infection NN cord-010092-uftc8inx 5134 13 markers marker NNS cord-010092-uftc8inx 5134 14 remains remain VBZ cord-010092-uftc8inx 5134 15 effective effective JJ cord-010092-uftc8inx 5134 16 : : : cord-010092-uftc8inx 5134 17 Russia Russia NNP cord-010092-uftc8inx 5134 18 more more RBR cord-010092-uftc8inx 5134 19 often often RB cord-010092-uftc8inx 5134 20 identifies identify VBZ cord-010092-uftc8inx 5134 21 HIV HIV NNP cord-010092-uftc8inx 5134 22 and and CC cord-010092-uftc8inx 5134 23 viral viral JJ cord-010092-uftc8inx 5134 24 hepatitis hepatitis NN cord-010092-uftc8inx 5134 25 C c NN cord-010092-uftc8inx 5134 26 from from IN cord-010092-uftc8inx 5134 27 potential potential JJ cord-010092-uftc8inx 5134 28 donors donor NNS cord-010092-uftc8inx 5134 29 , , , cord-010092-uftc8inx 5134 30 and and CC cord-010092-uftc8inx 5134 31 viral viral JJ cord-010092-uftc8inx 5134 32 hepatitis hepatitis NN cord-010092-uftc8inx 5134 33 B b NN cord-010092-uftc8inx 5134 34 and and CC cord-010092-uftc8inx 5134 35 syphilis syphili NNS cord-010092-uftc8inx 5134 36 are be VBP cord-010092-uftc8inx 5134 37 detected detect VBN cord-010092-uftc8inx 5134 38 in in IN cord-010092-uftc8inx 5134 39 Kazakhstan Kazakhstan NNP cord-010092-uftc8inx 5134 40 . . . cord-010092-uftc8inx 5135 1 0.7 0.7 CD cord-010092-uftc8inx 5135 2 % % NN cord-010092-uftc8inx 5135 3 of of IN cord-010092-uftc8inx 5135 4 donors donor NNS cord-010092-uftc8inx 5135 5 in in IN cord-010092-uftc8inx 5135 6 Kazakhstan Kazakhstan NNP cord-010092-uftc8inx 5135 7 are be VBP cord-010092-uftc8inx 5135 8 exempted exempt VBN cord-010092-uftc8inx 5135 9 due due IN cord-010092-uftc8inx 5135 10 to to IN cord-010092-uftc8inx 5135 11 the the DT cord-010092-uftc8inx 5135 12 results result NNS cord-010092-uftc8inx 5135 13 of of IN cord-010092-uftc8inx 5135 14 multiplex multiplex NN cord-010092-uftc8inx 5135 15 screening screening NN cord-010092-uftc8inx 5135 16 of of IN cord-010092-uftc8inx 5135 17 nucleic nucleic JJ cord-010092-uftc8inx 5135 18 acids acid NNS cord-010092-uftc8inx 5135 19 of of IN cord-010092-uftc8inx 5135 20 three three CD cord-010092-uftc8inx 5135 21 hemotransmissive hemotransmissive NN cord-010092-uftc8inx 5135 22 viruses virus NNS cord-010092-uftc8inx 5135 23 . . . cord-010092-uftc8inx 5136 1 Summary Summary NNP cord-010092-uftc8inx 5136 2 / / SYM cord-010092-uftc8inx 5136 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 5136 4 : : : cord-010092-uftc8inx 5137 1 The the DT cord-010092-uftc8inx 5137 2 blood blood NN cord-010092-uftc8inx 5137 3 services service NNS cord-010092-uftc8inx 5137 4 of of IN cord-010092-uftc8inx 5137 5 Russia Russia NNP cord-010092-uftc8inx 5137 6 and and CC cord-010092-uftc8inx 5137 7 Kazakhstan Kazakhstan NNP cord-010092-uftc8inx 5137 8 perform perform VBP cord-010092-uftc8inx 5137 9 tasks task NNS cord-010092-uftc8inx 5137 10 to to TO cord-010092-uftc8inx 5137 11 provide provide VB cord-010092-uftc8inx 5137 12 medical medical JJ cord-010092-uftc8inx 5137 13 organizations organization NNS cord-010092-uftc8inx 5137 14 with with IN cord-010092-uftc8inx 5137 15 effective effective JJ cord-010092-uftc8inx 5137 16 blood blood NN cord-010092-uftc8inx 5137 17 components component NNS cord-010092-uftc8inx 5137 18 . . . cord-010092-uftc8inx 5138 1 In in IN cord-010092-uftc8inx 5138 2 conditions condition NNS cord-010092-uftc8inx 5138 3 of of IN cord-010092-uftc8inx 5138 4 decreasing decrease VBG cord-010092-uftc8inx 5138 5 demand demand NN cord-010092-uftc8inx 5138 6 for for IN cord-010092-uftc8inx 5138 7 red red JJ cord-010092-uftc8inx 5138 8 blood blood NN cord-010092-uftc8inx 5138 9 cells cell NNS cord-010092-uftc8inx 5138 10 and and CC cord-010092-uftc8inx 5138 11 plasma plasma NN cord-010092-uftc8inx 5138 12 , , , cord-010092-uftc8inx 5138 13 it -PRON- PRP cord-010092-uftc8inx 5138 14 is be VBZ cord-010092-uftc8inx 5138 15 advisable advisable JJ cord-010092-uftc8inx 5138 16 to to TO cord-010092-uftc8inx 5138 17 focus focus VB cord-010092-uftc8inx 5138 18 on on IN cord-010092-uftc8inx 5138 19 the the DT cord-010092-uftc8inx 5138 20 efficiency efficiency NN cord-010092-uftc8inx 5138 21 of of IN cord-010092-uftc8inx 5138 22 resource resource NN cord-010092-uftc8inx 5138 23 use use NN cord-010092-uftc8inx 5138 24 and and CC cord-010092-uftc8inx 5138 25 improving improve VBG cord-010092-uftc8inx 5138 26 the the DT cord-010092-uftc8inx 5138 27 quality quality NN cord-010092-uftc8inx 5138 28 of of IN cord-010092-uftc8inx 5138 29 blood blood NN cord-010092-uftc8inx 5138 30 components component NNS cord-010092-uftc8inx 5138 31 produced produce VBN cord-010092-uftc8inx 5138 32 . . . cord-010092-uftc8inx 5139 1 Blood blood NN cord-010092-uftc8inx 5139 2 collection collection NN cord-010092-uftc8inx 5139 3 including include VBG cord-010092-uftc8inx 5139 4 apheresis apheresis NN cord-010092-uftc8inx 5139 5 P-091 p-091 NN cord-010092-uftc8inx 5139 6 Finnish Finnish NNP cord-010092-uftc8inx 5139 7 Red Red NNP cord-010092-uftc8inx 5139 8 Cross Cross NNP cord-010092-uftc8inx 5139 9 Blood Blood NNP cord-010092-uftc8inx 5139 10 Service Service NNP cord-010092-uftc8inx 5139 11 , , , cord-010092-uftc8inx 5139 12 Helsinki Helsinki NNP cord-010092-uftc8inx 5139 13 , , , cord-010092-uftc8inx 5139 14 Finland Finland NNP cord-010092-uftc8inx 5139 15 Background Background NNP cord-010092-uftc8inx 5139 16 : : : cord-010092-uftc8inx 5140 1 Skin skin NN cord-010092-uftc8inx 5140 2 disinfectant disinfectant NN cord-010092-uftc8inx 5140 3 must must MD cord-010092-uftc8inx 5140 4 effectively effectively RB cord-010092-uftc8inx 5140 5 reduce reduce VB cord-010092-uftc8inx 5140 6 microbes microbe NNS cord-010092-uftc8inx 5140 7 from from IN cord-010092-uftc8inx 5140 8 the the DT cord-010092-uftc8inx 5140 9 arm arm NN cord-010092-uftc8inx 5140 10 of of IN cord-010092-uftc8inx 5140 11 the the DT cord-010092-uftc8inx 5140 12 donor donor NN cord-010092-uftc8inx 5140 13 . . . cord-010092-uftc8inx 5141 1 As as IN cord-010092-uftc8inx 5141 2 a a DT cord-010092-uftc8inx 5141 3 result result NN cord-010092-uftc8inx 5141 4 of of IN cord-010092-uftc8inx 5141 5 poor poor JJ cord-010092-uftc8inx 5141 6 disinfecting disinfect VBG cord-010092-uftc8inx 5141 7 microbes microbe NNS cord-010092-uftc8inx 5141 8 may may MD cord-010092-uftc8inx 5141 9 be be VB cord-010092-uftc8inx 5141 10 transferred transfer VBN cord-010092-uftc8inx 5141 11 from from IN cord-010092-uftc8inx 5141 12 skin skin NN cord-010092-uftc8inx 5141 13 via via IN cord-010092-uftc8inx 5141 14 venepuncture venepuncture NN cord-010092-uftc8inx 5141 15 to to IN cord-010092-uftc8inx 5141 16 the the DT cord-010092-uftc8inx 5141 17 collected collect VBN cord-010092-uftc8inx 5141 18 blood blood NN cord-010092-uftc8inx 5141 19 and and CC cord-010092-uftc8inx 5141 20 contaminate contaminate VB cord-010092-uftc8inx 5141 21 the the DT cord-010092-uftc8inx 5141 22 blood blood NN cord-010092-uftc8inx 5141 23 components component NNS cord-010092-uftc8inx 5141 24 . . . cord-010092-uftc8inx 5142 1 Aims aim VBZ cord-010092-uftc8inx 5142 2 : : : cord-010092-uftc8inx 5143 1 To to TO cord-010092-uftc8inx 5143 2 ensure ensure VB cord-010092-uftc8inx 5143 3 the the DT cord-010092-uftc8inx 5143 4 efficiency efficiency NN cord-010092-uftc8inx 5143 5 of of IN cord-010092-uftc8inx 5143 6 the the DT cord-010092-uftc8inx 5143 7 skin skin NN cord-010092-uftc8inx 5143 8 disinfectant disinfectant NN cord-010092-uftc8inx 5143 9 used use VBN cord-010092-uftc8inx 5143 10 for for IN cord-010092-uftc8inx 5143 11 donor donor NN cord-010092-uftc8inx 5143 12 arm arm NN cord-010092-uftc8inx 5143 13 disinfecting disinfect VBG cord-010092-uftc8inx 5143 14 by by IN cord-010092-uftc8inx 5143 15 validation validation NN cord-010092-uftc8inx 5143 16 . . . cord-010092-uftc8inx 5144 1 The the DT cord-010092-uftc8inx 5144 2 validation validation NN cord-010092-uftc8inx 5144 3 has have VBZ cord-010092-uftc8inx 5144 4 two two CD cord-010092-uftc8inx 5144 5 criteria criterion NNS cord-010092-uftc8inx 5144 6 which which WDT cord-010092-uftc8inx 5144 7 the the DT cord-010092-uftc8inx 5144 8 post post JJ cord-010092-uftc8inx 5144 9 - - JJ cord-010092-uftc8inx 5144 10 disinfection disinfection JJ cord-010092-uftc8inx 5144 11 samples sample NNS cord-010092-uftc8inx 5144 12 must must MD cord-010092-uftc8inx 5144 13 achieve achieve VB cord-010092-uftc8inx 5144 14 : : : cord-010092-uftc8inx 5144 15 1 1 CD cord-010092-uftc8inx 5144 16 . . . cord-010092-uftc8inx 5145 1 No no DT cord-010092-uftc8inx 5145 2 bacteria bacteria NNS cord-010092-uftc8inx 5145 3 growth growth NN cord-010092-uftc8inx 5145 4 near near IN cord-010092-uftc8inx 5145 5 the the DT cord-010092-uftc8inx 5145 6 puncture puncture NN cord-010092-uftc8inx 5145 7 spot spot NN cord-010092-uftc8inx 5145 8 ( ( -LRB- cord-010092-uftc8inx 5145 9 result result NN cord-010092-uftc8inx 5145 10 0 0 CD cord-010092-uftc8inx 5145 11 CFU CFU NNP cord-010092-uftc8inx 5145 12 ) ) -RRB- cord-010092-uftc8inx 5145 13 in in IN cord-010092-uftc8inx 5145 14 ≥ ≥ CD cord-010092-uftc8inx 5145 15 90 90 CD cord-010092-uftc8inx 5145 16 % % NN cord-010092-uftc8inx 5145 17 of of IN cord-010092-uftc8inx 5145 18 the the DT cord-010092-uftc8inx 5145 19 samples sample NNS cord-010092-uftc8inx 5145 20 . . . cord-010092-uftc8inx 5146 1 2 2 LS cord-010092-uftc8inx 5146 2 . . . cord-010092-uftc8inx 5147 1 Total total JJ cord-010092-uftc8inx 5147 2 amount amount NN cord-010092-uftc8inx 5147 3 of of IN cord-010092-uftc8inx 5147 4 bacteria bacteria NNS cord-010092-uftc8inx 5147 5 on on IN cord-010092-uftc8inx 5147 6 average average JJ cord-010092-uftc8inx 5147 7 is be VBZ cord-010092-uftc8inx 5147 8 at at IN cord-010092-uftc8inx 5147 9 most most JJS cord-010092-uftc8inx 5147 10 2 2 CD cord-010092-uftc8inx 5147 11 CFU/25 cfu/25 NN cord-010092-uftc8inx 5147 12 cm cm NNS cord-010092-uftc8inx 5147 13 2 2 CD cord-010092-uftc8inx 5147 14 . . . cord-010092-uftc8inx 5148 1 At at IN cord-010092-uftc8inx 5148 2 most most RBS cord-010092-uftc8inx 5148 3 10 10 CD cord-010092-uftc8inx 5148 4 % % NN cord-010092-uftc8inx 5148 5 of of IN cord-010092-uftc8inx 5148 6 samples sample NNS cord-010092-uftc8inx 5148 7 are be VBP cord-010092-uftc8inx 5148 8 allowed allow VBN cord-010092-uftc8inx 5148 9 to to TO cord-010092-uftc8inx 5148 10 have have VB cord-010092-uftc8inx 5148 11 2 2 CD cord-010092-uftc8inx 5148 12 - - SYM cord-010092-uftc8inx 5148 13 10 10 CD cord-010092-uftc8inx 5148 14 CFU/25 CFU/25 NNS cord-010092-uftc8inx 5148 15 cm cm NNS cord-010092-uftc8inx 5148 16 2 2 CD cord-010092-uftc8inx 5148 17 . . . cord-010092-uftc8inx 5149 1 Methods method NNS cord-010092-uftc8inx 5149 2 : : : cord-010092-uftc8inx 5149 3 Microbiological microbiological JJ cord-010092-uftc8inx 5149 4 samples sample NNS cord-010092-uftc8inx 5149 5 were be VBD cord-010092-uftc8inx 5149 6 taken take VBN cord-010092-uftc8inx 5149 7 with with IN cord-010092-uftc8inx 5149 8 contact contact NN cord-010092-uftc8inx 5149 9 plates plate NNS cord-010092-uftc8inx 5149 10 from from IN cord-010092-uftc8inx 5149 11 30 30 CD cord-010092-uftc8inx 5149 12 voluntary voluntary JJ cord-010092-uftc8inx 5149 13 persons person NNS cord-010092-uftc8inx 5149 14 ' ' POS cord-010092-uftc8inx 5149 15 elbow elbow NN cord-010092-uftc8inx 5149 16 folds fold NNS cord-010092-uftc8inx 5149 17 before before RB cord-010092-uftc8inx 5149 18 and and CC cord-010092-uftc8inx 5149 19 after after IN cord-010092-uftc8inx 5149 20 skin skin NN cord-010092-uftc8inx 5149 21 disinfection disinfection NN cord-010092-uftc8inx 5149 22 . . . cord-010092-uftc8inx 5150 1 The the DT cord-010092-uftc8inx 5150 2 disinfecting disinfecting NN cord-010092-uftc8inx 5150 3 was be VBD cord-010092-uftc8inx 5150 4 performed perform VBN cord-010092-uftc8inx 5150 5 according accord VBG cord-010092-uftc8inx 5150 6 to to IN cord-010092-uftc8inx 5150 7 normal normal JJ cord-010092-uftc8inx 5150 8 procedure procedure NN cord-010092-uftc8inx 5150 9 by by IN cord-010092-uftc8inx 5150 10 five five CD cord-010092-uftc8inx 5150 11 nurses nurse NNS cord-010092-uftc8inx 5150 12 altogether altogether RB cord-010092-uftc8inx 5150 13 with with IN cord-010092-uftc8inx 5150 14 ethanol ethanol NN cord-010092-uftc8inx 5150 15 based base VBN cord-010092-uftc8inx 5150 16 disinfectant disinfectant NN cord-010092-uftc8inx 5150 17 used use VBN cord-010092-uftc8inx 5150 18 in in IN cord-010092-uftc8inx 5150 19 blood blood NN cord-010092-uftc8inx 5150 20 donation donation NN cord-010092-uftc8inx 5150 21 . . . cord-010092-uftc8inx 5151 1 On on IN cord-010092-uftc8inx 5151 2 the the DT cord-010092-uftc8inx 5151 3 sample sample NN cord-010092-uftc8inx 5151 4 plates plate VBZ cord-010092-uftc8inx 5151 5 an an DT cord-010092-uftc8inx 5151 6 X x NN cord-010092-uftc8inx 5151 7 was be VBD cord-010092-uftc8inx 5151 8 marked mark VBN cord-010092-uftc8inx 5151 9 and and CC cord-010092-uftc8inx 5151 10 this this DT cord-010092-uftc8inx 5151 11 was be VBD cord-010092-uftc8inx 5151 12 directed direct VBN cord-010092-uftc8inx 5151 13 to to IN cord-010092-uftc8inx 5151 14 the the DT cord-010092-uftc8inx 5151 15 puncture puncture NN cord-010092-uftc8inx 5151 16 spot spot NN cord-010092-uftc8inx 5151 17 pointed point VBN cord-010092-uftc8inx 5151 18 by by IN cord-010092-uftc8inx 5151 19 nurse nurse NN cord-010092-uftc8inx 5151 20 . . . cord-010092-uftc8inx 5152 1 Post post JJ cord-010092-uftc8inx 5152 2 - - JJ cord-010092-uftc8inx 5152 3 disinfection disinfection JJ cord-010092-uftc8inx 5152 4 sample sample NN cord-010092-uftc8inx 5152 5 was be VBD cord-010092-uftc8inx 5152 6 taken take VBN cord-010092-uftc8inx 5152 7 at at IN cord-010092-uftc8inx 5152 8 the the DT cord-010092-uftc8inx 5152 9 moment moment NN cord-010092-uftc8inx 5152 10 the the DT cord-010092-uftc8inx 5152 11 skin skin NN cord-010092-uftc8inx 5152 12 would would MD cord-010092-uftc8inx 5152 13 be be VB cord-010092-uftc8inx 5152 14 punctured puncture VBN cord-010092-uftc8inx 5152 15 with with IN cord-010092-uftc8inx 5152 16 needle needle NN cord-010092-uftc8inx 5152 17 . . . cord-010092-uftc8inx 5153 1 Results result NNS cord-010092-uftc8inx 5153 2 : : : cord-010092-uftc8inx 5154 1 The the DT cord-010092-uftc8inx 5154 2 amount amount NN cord-010092-uftc8inx 5154 3 of of IN cord-010092-uftc8inx 5154 4 bacteria bacteria NNS cord-010092-uftc8inx 5154 5 varied varied JJ cord-010092-uftc8inx 5154 6 from from IN cord-010092-uftc8inx 5154 7 20 20 CD cord-010092-uftc8inx 5154 8 to to IN cord-010092-uftc8inx 5154 9 above above IN cord-010092-uftc8inx 5154 10 500 500 CD cord-010092-uftc8inx 5154 11 CFU/25 CFU/25 NNS cord-010092-uftc8inx 5154 12 cm cm NNS cord-010092-uftc8inx 5154 13 2 2 CD cord-010092-uftc8inx 5154 14 in in IN cord-010092-uftc8inx 5154 15 the the DT cord-010092-uftc8inx 5154 16 pre pre JJ cord-010092-uftc8inx 5154 17 - - JJ cord-010092-uftc8inx 5154 18 disinfection disinfection JJ cord-010092-uftc8inx 5154 19 samples sample NNS cord-010092-uftc8inx 5154 20 . . . cord-010092-uftc8inx 5155 1 Disinfection disinfection NN cord-010092-uftc8inx 5155 2 reduced reduce VBN cord-010092-uftc8inx 5155 3 bacteria bacteria NNS cord-010092-uftc8inx 5155 4 very very RB cord-010092-uftc8inx 5155 5 well well RB cord-010092-uftc8inx 5155 6 ; ; : cord-010092-uftc8inx 5155 7 the the DT cord-010092-uftc8inx 5155 8 critical critical JJ cord-010092-uftc8inx 5155 9 puncture puncture NN cord-010092-uftc8inx 5155 10 spot spot NN cord-010092-uftc8inx 5155 11 was be VBD cord-010092-uftc8inx 5155 12 totally totally RB cord-010092-uftc8inx 5155 13 clean clean JJ cord-010092-uftc8inx 5155 14 ( ( -LRB- cord-010092-uftc8inx 5155 15 0 0 CD cord-010092-uftc8inx 5155 16 CFU/25 cfu/25 NN cord-010092-uftc8inx 5155 17 cm cm NNS cord-010092-uftc8inx 5155 18 2 2 CD cord-010092-uftc8inx 5155 19 ) ) -RRB- cord-010092-uftc8inx 5155 20 in in IN cord-010092-uftc8inx 5155 21 93.3 93.3 CD cord-010092-uftc8inx 5155 22 % % NN cord-010092-uftc8inx 5155 23 of of IN cord-010092-uftc8inx 5155 24 the the DT cord-010092-uftc8inx 5155 25 samples sample NNS cord-010092-uftc8inx 5155 26 and and CC cord-010092-uftc8inx 5155 27 86.7 86.7 CD cord-010092-uftc8inx 5155 28 % % NN cord-010092-uftc8inx 5155 29 of of IN cord-010092-uftc8inx 5155 30 the the DT cord-010092-uftc8inx 5155 31 samples sample NNS cord-010092-uftc8inx 5155 32 had have VBD cord-010092-uftc8inx 5155 33 0 0 CD cord-010092-uftc8inx 5155 34 or or CC cord-010092-uftc8inx 5155 35 only only RB cord-010092-uftc8inx 5155 36 1 1 CD cord-010092-uftc8inx 5155 37 CFU/25 cfu/25 NN cord-010092-uftc8inx 5155 38 cm cm NNS cord-010092-uftc8inx 5155 39 2 2 CD cord-010092-uftc8inx 5155 40 . . . cord-010092-uftc8inx 5156 1 The the DT cord-010092-uftc8inx 5156 2 average average JJ cord-010092-uftc8inx 5156 3 number number NN cord-010092-uftc8inx 5156 4 of of IN cord-010092-uftc8inx 5156 5 bacteria bacteria NNS cord-010092-uftc8inx 5156 6 after after IN cord-010092-uftc8inx 5156 7 disinfection disinfection NN cord-010092-uftc8inx 5156 8 was be VBD cord-010092-uftc8inx 5156 9 0,6 0,6 CD cord-010092-uftc8inx 5156 10 CFU/25 CFU/25 NNP cord-010092-uftc8inx 5156 11 cm cm NNP cord-010092-uftc8inx 5156 12 2 2 CD cord-010092-uftc8inx 5156 13 and and CC cord-010092-uftc8inx 5156 14 the the DT cord-010092-uftc8inx 5156 15 maximum maximum JJ cord-010092-uftc8inx 5156 16 number number NN cord-010092-uftc8inx 5156 17 was be VBD cord-010092-uftc8inx 5156 18 4 4 CD cord-010092-uftc8inx 5156 19 CFU/25 cfu/25 NN cord-010092-uftc8inx 5156 20 cm cm NNS cord-010092-uftc8inx 5156 21 2 2 CD cord-010092-uftc8inx 5156 22 . . . cord-010092-uftc8inx 5157 1 Most Most JJS cord-010092-uftc8inx 5157 2 of of IN cord-010092-uftc8inx 5157 3 the the DT cord-010092-uftc8inx 5157 4 remaining remain VBG cord-010092-uftc8inx 5157 5 bacteria bacteria NNS cord-010092-uftc8inx 5157 6 were be VBD cord-010092-uftc8inx 5157 7 single single JJ cord-010092-uftc8inx 5157 8 colonies colony NNS cord-010092-uftc8inx 5157 9 at at IN cord-010092-uftc8inx 5157 10 the the DT cord-010092-uftc8inx 5157 11 edges edge NNS cord-010092-uftc8inx 5157 12 of of IN cord-010092-uftc8inx 5157 13 the the DT cord-010092-uftc8inx 5157 14 plates plate NNS cord-010092-uftc8inx 5157 15 . . . cord-010092-uftc8inx 5158 1 Summary Summary NNP cord-010092-uftc8inx 5158 2 / / SYM cord-010092-uftc8inx 5158 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 5158 4 : : : cord-010092-uftc8inx 5159 1 Both both DT cord-010092-uftc8inx 5159 2 main main JJ cord-010092-uftc8inx 5159 3 criteria criterion NNS cord-010092-uftc8inx 5159 4 are be VBP cord-010092-uftc8inx 5159 5 fulfilled fulfil VBN cord-010092-uftc8inx 5159 6 . . . cord-010092-uftc8inx 5160 1 The the DT cord-010092-uftc8inx 5160 2 sub sub JJ cord-010092-uftc8inx 5160 3 criteria criterion NNS cord-010092-uftc8inx 5160 4 of of IN cord-010092-uftc8inx 5160 5 the the DT cord-010092-uftc8inx 5160 6 second second JJ cord-010092-uftc8inx 5160 7 main main JJ cord-010092-uftc8inx 5160 8 criteria criterion NNS cord-010092-uftc8inx 5160 9 is be VBZ cord-010092-uftc8inx 5160 10 also also RB cord-010092-uftc8inx 5160 11 full full JJ cord-010092-uftc8inx 5160 12 filled fill VBN cord-010092-uftc8inx 5160 13 if if IN cord-010092-uftc8inx 5160 14 the the DT cord-010092-uftc8inx 5160 15 not not RB cord-010092-uftc8inx 5160 16 so so RB cord-010092-uftc8inx 5160 17 critical critical JJ cord-010092-uftc8inx 5160 18 colonies colony NNS cord-010092-uftc8inx 5160 19 at at IN cord-010092-uftc8inx 5160 20 the the DT cord-010092-uftc8inx 5160 21 edges edge NNS cord-010092-uftc8inx 5160 22 of of IN cord-010092-uftc8inx 5160 23 the the DT cord-010092-uftc8inx 5160 24 plates plate NNS cord-010092-uftc8inx 5160 25 are be VBP cord-010092-uftc8inx 5160 26 not not RB cord-010092-uftc8inx 5160 27 taken take VBN cord-010092-uftc8inx 5160 28 into into IN cord-010092-uftc8inx 5160 29 account account NN cord-010092-uftc8inx 5160 30 . . . cord-010092-uftc8inx 5161 1 The the DT cord-010092-uftc8inx 5161 2 skin skin NN cord-010092-uftc8inx 5161 3 disinfectant disinfectant NN cord-010092-uftc8inx 5161 4 in in IN cord-010092-uftc8inx 5161 5 question question NN cord-010092-uftc8inx 5161 6 is be VBZ cord-010092-uftc8inx 5161 7 shown show VBN cord-010092-uftc8inx 5161 8 to to TO cord-010092-uftc8inx 5161 9 be be VB cord-010092-uftc8inx 5161 10 effective effective JJ cord-010092-uftc8inx 5161 11 and and CC cord-010092-uftc8inx 5161 12 can can MD cord-010092-uftc8inx 5161 13 still still RB cord-010092-uftc8inx 5161 14 be be VB cord-010092-uftc8inx 5161 15 used use VBN cord-010092-uftc8inx 5161 16 in in IN cord-010092-uftc8inx 5161 17 blood blood NN cord-010092-uftc8inx 5161 18 donation donation NN cord-010092-uftc8inx 5161 19 paying pay VBG cord-010092-uftc8inx 5161 20 attention attention NN cord-010092-uftc8inx 5161 21 to to IN cord-010092-uftc8inx 5161 22 thorough thorough JJ cord-010092-uftc8inx 5161 23 procedure procedure NN cord-010092-uftc8inx 5161 24 performance performance NN cord-010092-uftc8inx 5161 25 according accord VBG cord-010092-uftc8inx 5161 26 to to IN cord-010092-uftc8inx 5161 27 the the DT cord-010092-uftc8inx 5161 28 instructions instruction NNS cord-010092-uftc8inx 5161 29 and and CC cord-010092-uftc8inx 5161 30 sufficient sufficient JJ cord-010092-uftc8inx 5161 31 drying drying NN cord-010092-uftc8inx 5161 32 time time NN cord-010092-uftc8inx 5161 33 of of IN cord-010092-uftc8inx 5161 34 the the DT cord-010092-uftc8inx 5161 35 disinfectant disinfectant NN cord-010092-uftc8inx 5161 36 . . . cord-010092-uftc8inx 5162 1 Background background NN cord-010092-uftc8inx 5162 2 : : : cord-010092-uftc8inx 5163 1 Research research NN cord-010092-uftc8inx 5163 2 questions question NNS cord-010092-uftc8inx 5163 3 involving involve VBG cord-010092-uftc8inx 5163 4 blood blood NN cord-010092-uftc8inx 5163 5 donation donation NN cord-010092-uftc8inx 5163 6 and and CC cord-010092-uftc8inx 5163 7 recipient recipient NN cord-010092-uftc8inx 5163 8 data datum NNS cord-010092-uftc8inx 5163 9 often often RB cord-010092-uftc8inx 5163 10 require require VBP cord-010092-uftc8inx 5163 11 advanced advanced JJ cord-010092-uftc8inx 5163 12 statistical statistical JJ cord-010092-uftc8inx 5163 13 methodologies methodology NNS cord-010092-uftc8inx 5163 14 . . . cord-010092-uftc8inx 5164 1 While while IN cord-010092-uftc8inx 5164 2 such such JJ cord-010092-uftc8inx 5164 3 methodologies methodology NNS cord-010092-uftc8inx 5164 4 may may MD cord-010092-uftc8inx 5164 5 appear appear VB cord-010092-uftc8inx 5164 6 in in IN cord-010092-uftc8inx 5164 7 other other JJ cord-010092-uftc8inx 5164 8 medical medical JJ cord-010092-uftc8inx 5164 9 research research NN cord-010092-uftc8inx 5164 10 areas area NNS cord-010092-uftc8inx 5164 11 , , , cord-010092-uftc8inx 5164 12 specific specific JJ cord-010092-uftc8inx 5164 13 tailor tailor NN cord-010092-uftc8inx 5164 14 - - HYPH cord-010092-uftc8inx 5164 15 made make VBN cord-010092-uftc8inx 5164 16 statistical statistical JJ cord-010092-uftc8inx 5164 17 tools tool NNS cord-010092-uftc8inx 5164 18 and and CC cord-010092-uftc8inx 5164 19 approaches approach NNS cord-010092-uftc8inx 5164 20 are be VBP cord-010092-uftc8inx 5164 21 required require VBN cord-010092-uftc8inx 5164 22 for for IN cord-010092-uftc8inx 5164 23 the the DT cord-010092-uftc8inx 5164 24 analysis analysis NN cord-010092-uftc8inx 5164 25 of of IN cord-010092-uftc8inx 5164 26 blood blood NN cord-010092-uftc8inx 5164 27 - - HYPH cord-010092-uftc8inx 5164 28 related relate VBN cord-010092-uftc8inx 5164 29 data datum NNS cord-010092-uftc8inx 5164 30 . . . cord-010092-uftc8inx 5165 1 These these DT cord-010092-uftc8inx 5165 2 toolkits toolkit NNS cord-010092-uftc8inx 5165 3 , , , cord-010092-uftc8inx 5165 4 which which WDT cord-010092-uftc8inx 5165 5 often often RB cord-010092-uftc8inx 5165 6 require require VBP cord-010092-uftc8inx 5165 7 collaboration collaboration NN cord-010092-uftc8inx 5165 8 , , , cord-010092-uftc8inx 5165 9 are be VBP cord-010092-uftc8inx 5165 10 not not RB cord-010092-uftc8inx 5165 11 always always RB cord-010092-uftc8inx 5165 12 readily readily RB cord-010092-uftc8inx 5165 13 available available JJ cord-010092-uftc8inx 5165 14 to to IN cord-010092-uftc8inx 5165 15 blood blood NN cord-010092-uftc8inx 5165 16 services service NNS cord-010092-uftc8inx 5165 17 , , , cord-010092-uftc8inx 5165 18 especially especially RB cord-010092-uftc8inx 5165 19 so so RB cord-010092-uftc8inx 5165 20 in in IN cord-010092-uftc8inx 5165 21 resource resource NN cord-010092-uftc8inx 5165 22 - - HYPH cord-010092-uftc8inx 5165 23 limited limit VBN cord-010092-uftc8inx 5165 24 settings setting NNS cord-010092-uftc8inx 5165 25 . . . cord-010092-uftc8inx 5166 1 An an DT cord-010092-uftc8inx 5166 2 international international JJ cord-010092-uftc8inx 5166 3 network network NN cord-010092-uftc8inx 5166 4 of of IN cord-010092-uftc8inx 5166 5 statisticians statistician NNS cord-010092-uftc8inx 5166 6 , , , cord-010092-uftc8inx 5166 7 epidemiologists epidemiologist NNS cord-010092-uftc8inx 5166 8 and and CC cord-010092-uftc8inx 5166 9 clinical clinical JJ cord-010092-uftc8inx 5166 10 researchers researcher NNS cord-010092-uftc8inx 5166 11 has have VBZ cord-010092-uftc8inx 5166 12 been be VBN cord-010092-uftc8inx 5166 13 established establish VBN cord-010092-uftc8inx 5166 14 for for IN cord-010092-uftc8inx 5166 15 this this DT cord-010092-uftc8inx 5166 16 purpose purpose NN cord-010092-uftc8inx 5166 17 , , , cord-010092-uftc8inx 5166 18 which which WDT cord-010092-uftc8inx 5166 19 started start VBD cord-010092-uftc8inx 5166 20 with with IN cord-010092-uftc8inx 5166 21 an an DT cord-010092-uftc8inx 5166 22 Invited Invited NNP cord-010092-uftc8inx 5166 23 Session session NN cord-010092-uftc8inx 5166 24 at at IN cord-010092-uftc8inx 5166 25 the the DT cord-010092-uftc8inx 5166 26 2018 2018 CD cord-010092-uftc8inx 5166 27 meetings meeting NNS cord-010092-uftc8inx 5166 28 of of IN cord-010092-uftc8inx 5166 29 the the DT cord-010092-uftc8inx 5166 30 International International NNP cord-010092-uftc8inx 5166 31 Biometric Biometric NNP cord-010092-uftc8inx 5166 32 Society Society NNP cord-010092-uftc8inx 5166 33 . . . cord-010092-uftc8inx 5167 1 Aims aim VBZ cord-010092-uftc8inx 5167 2 : : : cord-010092-uftc8inx 5168 1 To to TO cord-010092-uftc8inx 5168 2 exchange exchange VB cord-010092-uftc8inx 5168 3 ideas idea NNS cord-010092-uftc8inx 5168 4 , , , cord-010092-uftc8inx 5168 5 experience experience NN cord-010092-uftc8inx 5168 6 and and CC cord-010092-uftc8inx 5168 7 knowledge knowledge NN cord-010092-uftc8inx 5168 8 to to TO cord-010092-uftc8inx 5168 9 further further RB cord-010092-uftc8inx 5168 10 improve improve VB cord-010092-uftc8inx 5168 11 the the DT cord-010092-uftc8inx 5168 12 quality quality NN cord-010092-uftc8inx 5168 13 of of IN cord-010092-uftc8inx 5168 14 blood blood NN cord-010092-uftc8inx 5168 15 sector sector NN cord-010092-uftc8inx 5168 16 research research NN cord-010092-uftc8inx 5168 17 . . . cord-010092-uftc8inx 5169 1 Methods method NNS cord-010092-uftc8inx 5169 2 : : : cord-010092-uftc8inx 5169 3 Currently currently RB cord-010092-uftc8inx 5169 4 our -PRON- PRP$ cord-010092-uftc8inx 5169 5 network network NN cord-010092-uftc8inx 5169 6 covers cover VBZ cord-010092-uftc8inx 5169 7 four four CD cord-010092-uftc8inx 5169 8 major major JJ cord-010092-uftc8inx 5169 9 blood blood NN cord-010092-uftc8inx 5169 10 services service NNS cord-010092-uftc8inx 5169 11 and and CC cord-010092-uftc8inx 5169 12 members member NNS cord-010092-uftc8inx 5169 13 from from IN cord-010092-uftc8inx 5169 14 five five CD cord-010092-uftc8inx 5169 15 different different JJ cord-010092-uftc8inx 5169 16 countries country NNS cord-010092-uftc8inx 5169 17 . . . cord-010092-uftc8inx 5170 1 The the DT cord-010092-uftc8inx 5170 2 network network NN cord-010092-uftc8inx 5170 3 has have VBZ cord-010092-uftc8inx 5170 4 monthly monthly JJ cord-010092-uftc8inx 5170 5 conference conference NN cord-010092-uftc8inx 5170 6 calls call NNS cord-010092-uftc8inx 5170 7 about about IN cord-010092-uftc8inx 5170 8 past past JJ cord-010092-uftc8inx 5170 9 and and CC cord-010092-uftc8inx 5170 10 current current JJ cord-010092-uftc8inx 5170 11 research research NN cord-010092-uftc8inx 5170 12 topics topic NNS cord-010092-uftc8inx 5170 13 . . . cord-010092-uftc8inx 5171 1 We -PRON- PRP cord-010092-uftc8inx 5171 2 wish wish VBP cord-010092-uftc8inx 5171 3 to to TO cord-010092-uftc8inx 5171 4 extend extend VB cord-010092-uftc8inx 5171 5 this this DT cord-010092-uftc8inx 5171 6 network network NN cord-010092-uftc8inx 5171 7 further far RBR cord-010092-uftc8inx 5171 8 , , , cord-010092-uftc8inx 5171 9 and and CC cord-010092-uftc8inx 5171 10 establish establish VB cord-010092-uftc8inx 5171 11 a a DT cord-010092-uftc8inx 5171 12 subcommittee subcommittee NN cord-010092-uftc8inx 5171 13 on on IN cord-010092-uftc8inx 5171 14 statistical statistical JJ cord-010092-uftc8inx 5171 15 and and CC cord-010092-uftc8inx 5171 16 epidemiological epidemiological JJ cord-010092-uftc8inx 5171 17 methodology methodology NN cord-010092-uftc8inx 5171 18 with with IN cord-010092-uftc8inx 5171 19 regular regular JJ cord-010092-uftc8inx 5171 20 face face NN cord-010092-uftc8inx 5171 21 - - HYPH cord-010092-uftc8inx 5171 22 toface toface NN cord-010092-uftc8inx 5171 23 meetings meeting NNS cord-010092-uftc8inx 5171 24 at at IN cord-010092-uftc8inx 5171 25 an an DT cord-010092-uftc8inx 5171 26 international international JJ cord-010092-uftc8inx 5171 27 organization organization NN cord-010092-uftc8inx 5171 28 such such JJ cord-010092-uftc8inx 5171 29 as as IN cord-010092-uftc8inx 5171 30 ISBT ISBT NNP cord-010092-uftc8inx 5171 31 . . . cord-010092-uftc8inx 5172 1 Results result NNS cord-010092-uftc8inx 5172 2 : : : cord-010092-uftc8inx 5173 1 The the DT cord-010092-uftc8inx 5173 2 monthly monthly JJ cord-010092-uftc8inx 5173 3 meetings meeting NNS cord-010092-uftc8inx 5173 4 have have VBP cord-010092-uftc8inx 5173 5 already already RB cord-010092-uftc8inx 5173 6 demonstrated demonstrate VBN cord-010092-uftc8inx 5173 7 that that IN cord-010092-uftc8inx 5173 8 the the DT cord-010092-uftc8inx 5173 9 members member NNS cord-010092-uftc8inx 5173 10 share share VBP cord-010092-uftc8inx 5173 11 common common JJ cord-010092-uftc8inx 5173 12 problems problem NNS cord-010092-uftc8inx 5173 13 and and CC cord-010092-uftc8inx 5173 14 interests interest NNS cord-010092-uftc8inx 5173 15 . . . cord-010092-uftc8inx 5174 1 For for IN cord-010092-uftc8inx 5174 2 example example NN cord-010092-uftc8inx 5174 3 , , , cord-010092-uftc8inx 5174 4 we -PRON- PRP cord-010092-uftc8inx 5174 5 are be VBP cord-010092-uftc8inx 5174 6 discussing discuss VBG cord-010092-uftc8inx 5174 7 techniques technique NNS cord-010092-uftc8inx 5174 8 to to TO cord-010092-uftc8inx 5174 9 analyze analyze VB cord-010092-uftc8inx 5174 10 data datum NNS cord-010092-uftc8inx 5174 11 with with IN cord-010092-uftc8inx 5174 12 repeated repeat VBN cord-010092-uftc8inx 5174 13 measurements measurement NNS cord-010092-uftc8inx 5174 14 , , , cord-010092-uftc8inx 5174 15 e.g. e.g. RB cord-010092-uftc8inx 5174 16 eligibility eligibility NN cord-010092-uftc8inx 5174 17 haemoglobin haemoglobin NN cord-010092-uftc8inx 5174 18 tests test NNS cord-010092-uftc8inx 5174 19 , , , cord-010092-uftc8inx 5174 20 ways way NNS cord-010092-uftc8inx 5174 21 to to TO cord-010092-uftc8inx 5174 22 assess assess VB cord-010092-uftc8inx 5174 23 the the DT cord-010092-uftc8inx 5174 24 healthy healthy JJ cord-010092-uftc8inx 5174 25 donor donor NN cord-010092-uftc8inx 5174 26 effect effect NN cord-010092-uftc8inx 5174 27 , , , cord-010092-uftc8inx 5174 28 e.g. e.g. IN cord-010092-uftc8inx 5174 29 determining determine VBG cord-010092-uftc8inx 5174 30 appropriate appropriate JJ cord-010092-uftc8inx 5174 31 controls control NNS cord-010092-uftc8inx 5174 32 groups group NNS cord-010092-uftc8inx 5174 33 , , , cord-010092-uftc8inx 5174 34 and and CC cord-010092-uftc8inx 5174 35 predictive predictive JJ cord-010092-uftc8inx 5174 36 models model NNS cord-010092-uftc8inx 5174 37 of of IN cord-010092-uftc8inx 5174 38 blood blood NN cord-010092-uftc8inx 5174 39 supply supply NN cord-010092-uftc8inx 5174 40 and and CC cord-010092-uftc8inx 5174 41 demand demand NN cord-010092-uftc8inx 5174 42 , , , cord-010092-uftc8inx 5174 43 e.g. e.g. IN cord-010092-uftc8inx 5174 44 stochastic stochastic JJ cord-010092-uftc8inx 5174 45 processes process NNS cord-010092-uftc8inx 5174 46 and and CC cord-010092-uftc8inx 5174 47 queuing queuing NN cord-010092-uftc8inx 5174 48 models model NNS cord-010092-uftc8inx 5174 49 . . . cord-010092-uftc8inx 5175 1 The the DT cord-010092-uftc8inx 5175 2 network network NN cord-010092-uftc8inx 5175 3 also also RB cord-010092-uftc8inx 5175 4 aims aim VBZ cord-010092-uftc8inx 5175 5 to to TO cord-010092-uftc8inx 5175 6 organize organize VB cord-010092-uftc8inx 5175 7 training training NN cord-010092-uftc8inx 5175 8 sessions session NNS cord-010092-uftc8inx 5175 9 in in IN cord-010092-uftc8inx 5175 10 methodology methodology NN cord-010092-uftc8inx 5175 11 either either CC cord-010092-uftc8inx 5175 12 on on IN cord-010092-uftc8inx 5175 13 site site NN cord-010092-uftc8inx 5175 14 and/or and/or CC cord-010092-uftc8inx 5175 15 by by IN cord-010092-uftc8inx 5175 16 developing develop VBG cord-010092-uftc8inx 5175 17 web web NN cord-010092-uftc8inx 5175 18 lectures lecture NNS cord-010092-uftc8inx 5175 19 . . . cord-010092-uftc8inx 5176 1 Summary Summary NNP cord-010092-uftc8inx 5176 2 / / SYM cord-010092-uftc8inx 5176 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 5176 4 : : : cord-010092-uftc8inx 5177 1 An an DT cord-010092-uftc8inx 5177 2 international international JJ cord-010092-uftc8inx 5177 3 network network NN cord-010092-uftc8inx 5177 4 on on IN cord-010092-uftc8inx 5177 5 statistical statistical JJ cord-010092-uftc8inx 5177 6 methodology methodology NN cord-010092-uftc8inx 5177 7 for for IN cord-010092-uftc8inx 5177 8 the the DT cord-010092-uftc8inx 5177 9 analysis analysis NN cord-010092-uftc8inx 5177 10 of of IN cord-010092-uftc8inx 5177 11 blood blood NN cord-010092-uftc8inx 5177 12 donation donation NN cord-010092-uftc8inx 5177 13 and and CC cord-010092-uftc8inx 5177 14 recipient recipient NN cord-010092-uftc8inx 5177 15 data datum NNS cord-010092-uftc8inx 5177 16 will will MD cord-010092-uftc8inx 5177 17 improve improve VB cord-010092-uftc8inx 5177 18 the the DT cord-010092-uftc8inx 5177 19 quality quality NN cord-010092-uftc8inx 5177 20 of of IN cord-010092-uftc8inx 5177 21 research research NN cord-010092-uftc8inx 5177 22 in in IN cord-010092-uftc8inx 5177 23 the the DT cord-010092-uftc8inx 5177 24 field field NN cord-010092-uftc8inx 5177 25 of of IN cord-010092-uftc8inx 5177 26 transfusion transfusion NN cord-010092-uftc8inx 5177 27 medicine medicine NN cord-010092-uftc8inx 5177 28 research research NN cord-010092-uftc8inx 5177 29 . . . cord-010092-uftc8inx 5178 1 Expanding expand VBG cord-010092-uftc8inx 5178 2 the the DT cord-010092-uftc8inx 5178 3 network network NN cord-010092-uftc8inx 5178 4 to to TO cord-010092-uftc8inx 5178 5 include include VB cord-010092-uftc8inx 5178 6 countries country NNS cord-010092-uftc8inx 5178 7 and and CC cord-010092-uftc8inx 5178 8 blood blood NN cord-010092-uftc8inx 5178 9 services service NNS cord-010092-uftc8inx 5178 10 in in IN cord-010092-uftc8inx 5178 11 research research NN cord-010092-uftc8inx 5178 12 limited limited JJ cord-010092-uftc8inx 5178 13 settings setting NNS cord-010092-uftc8inx 5178 14 needs need VBZ cord-010092-uftc8inx 5178 15 to to TO cord-010092-uftc8inx 5178 16 be be VB cord-010092-uftc8inx 5178 17 actively actively RB cord-010092-uftc8inx 5178 18 pursued pursue VBN cord-010092-uftc8inx 5178 19 . . . cord-010092-uftc8inx 5179 1 Background background NN cord-010092-uftc8inx 5179 2 : : : cord-010092-uftc8inx 5180 1 Blood blood NN cord-010092-uftc8inx 5180 2 donor donor NN cord-010092-uftc8inx 5180 3 hemoglobin hemoglobin NN cord-010092-uftc8inx 5180 4 concentration concentration NN cord-010092-uftc8inx 5180 5 ( ( -LRB- cord-010092-uftc8inx 5180 6 Hb Hb NNP cord-010092-uftc8inx 5180 7 ) ) -RRB- cord-010092-uftc8inx 5180 8 is be VBZ cord-010092-uftc8inx 5180 9 commonly commonly RB cord-010092-uftc8inx 5180 10 measured measure VBN cord-010092-uftc8inx 5180 11 from from IN cord-010092-uftc8inx 5180 12 a a DT cord-010092-uftc8inx 5180 13 skin skin NN cord-010092-uftc8inx 5180 14 - - HYPH cord-010092-uftc8inx 5180 15 prick prick NN cord-010092-uftc8inx 5180 16 sample sample NN cord-010092-uftc8inx 5180 17 at at IN cord-010092-uftc8inx 5180 18 the the DT cord-010092-uftc8inx 5180 19 donation donation NN cord-010092-uftc8inx 5180 20 site site NN cord-010092-uftc8inx 5180 21 , , , cord-010092-uftc8inx 5180 22 and and CC cord-010092-uftc8inx 5180 23 low low JJ cord-010092-uftc8inx 5180 24 Hb Hb NNP cord-010092-uftc8inx 5180 25 is be VBZ cord-010092-uftc8inx 5180 26 the the DT cord-010092-uftc8inx 5180 27 most most RBS cord-010092-uftc8inx 5180 28 common common JJ cord-010092-uftc8inx 5180 29 reason reason NN cord-010092-uftc8inx 5180 30 for for IN cord-010092-uftc8inx 5180 31 temporary temporary JJ cord-010092-uftc8inx 5180 32 donor donor NN cord-010092-uftc8inx 5180 33 deferral deferral NN cord-010092-uftc8inx 5180 34 . . . cord-010092-uftc8inx 5181 1 While while IN cord-010092-uftc8inx 5181 2 a a DT cord-010092-uftc8inx 5181 3 proportion proportion NN cord-010092-uftc8inx 5181 4 of of IN cord-010092-uftc8inx 5181 5 the the DT cord-010092-uftc8inx 5181 6 deferrals deferral NNS cord-010092-uftc8inx 5181 7 do do VBP cord-010092-uftc8inx 5181 8 reflect reflect VB cord-010092-uftc8inx 5181 9 true true JJ cord-010092-uftc8inx 5181 10 low low JJ cord-010092-uftc8inx 5181 11 Hb Hb NNP cord-010092-uftc8inx 5181 12 , , , cord-010092-uftc8inx 5182 1 the the DT cord-010092-uftc8inx 5182 2 skin skin NN cord-010092-uftc8inx 5182 3 - - HYPH cord-010092-uftc8inx 5182 4 prick prick NN cord-010092-uftc8inx 5182 5 sample sample NN cord-010092-uftc8inx 5182 6 is be VBZ cord-010092-uftc8inx 5182 7 prone prone JJ cord-010092-uftc8inx 5182 8 to to IN cord-010092-uftc8inx 5182 9 preanalytical preanalytical JJ cord-010092-uftc8inx 5182 10 error error NN cord-010092-uftc8inx 5182 11 and and CC cord-010092-uftc8inx 5182 12 variation variation NN cord-010092-uftc8inx 5182 13 resulting result VBG cord-010092-uftc8inx 5182 14 in in IN cord-010092-uftc8inx 5182 15 false false JJ cord-010092-uftc8inx 5182 16 deferrals deferral NNS cord-010092-uftc8inx 5182 17 . . . cord-010092-uftc8inx 5183 1 Aims aim VBZ cord-010092-uftc8inx 5183 2 : : : cord-010092-uftc8inx 5184 1 We -PRON- PRP cord-010092-uftc8inx 5184 2 assessed assess VBD cord-010092-uftc8inx 5184 3 the the DT cord-010092-uftc8inx 5184 4 applicability applicability NN cord-010092-uftc8inx 5184 5 of of IN cord-010092-uftc8inx 5184 6 a a DT cord-010092-uftc8inx 5184 7 venous venous JJ cord-010092-uftc8inx 5184 8 blood blood NN cord-010092-uftc8inx 5184 9 sample sample NN cord-010092-uftc8inx 5184 10 for for IN cord-010092-uftc8inx 5184 11 second second JJ cord-010092-uftc8inx 5184 12 - - HYPH cord-010092-uftc8inx 5184 13 line line NN cord-010092-uftc8inx 5184 14 Hb Hb NNP cord-010092-uftc8inx 5184 15 screening screening NN cord-010092-uftc8inx 5184 16 in in IN cord-010092-uftc8inx 5184 17 blood blood NN cord-010092-uftc8inx 5184 18 donors donor NNS cord-010092-uftc8inx 5184 19 failing fail VBG cord-010092-uftc8inx 5184 20 the the DT cord-010092-uftc8inx 5184 21 initial initial JJ cord-010092-uftc8inx 5184 22 skin skin NN cord-010092-uftc8inx 5184 23 - - HYPH cord-010092-uftc8inx 5184 24 prick prick NN cord-010092-uftc8inx 5184 25 test test NN cord-010092-uftc8inx 5184 26 . . . cord-010092-uftc8inx 5185 1 Methods method NNS cord-010092-uftc8inx 5185 2 : : : cord-010092-uftc8inx 5186 1 Initial initial JJ cord-010092-uftc8inx 5186 2 Hb Hb NNP cord-010092-uftc8inx 5186 3 was be VBD cord-010092-uftc8inx 5186 4 measured measure VBN cord-010092-uftc8inx 5186 5 from from IN cord-010092-uftc8inx 5186 6 a a DT cord-010092-uftc8inx 5186 7 skin skin NN cord-010092-uftc8inx 5186 8 - - HYPH cord-010092-uftc8inx 5186 9 prick prick NN cord-010092-uftc8inx 5186 10 sample sample NN cord-010092-uftc8inx 5186 11 with with IN cord-010092-uftc8inx 5186 12 the the DT cord-010092-uftc8inx 5186 13 HemoCue HemoCue NNP cord-010092-uftc8inx 5186 14 Hb201 Hb201 NNS cord-010092-uftc8inx 5186 15 + + CC cord-010092-uftc8inx 5186 16 ( ( -LRB- cord-010092-uftc8inx 5186 17 HemoCue HemoCue NNP cord-010092-uftc8inx 5186 18 AB AB NNP cord-010092-uftc8inx 5186 19 ) ) -RRB- cord-010092-uftc8inx 5186 20 point point NN cord-010092-uftc8inx 5186 21 - - HYPH cord-010092-uftc8inx 5186 22 of of IN cord-010092-uftc8inx 5186 23 - - HYPH cord-010092-uftc8inx 5186 24 care care NN cord-010092-uftc8inx 5186 25 ( ( -LRB- cord-010092-uftc8inx 5186 26 POC poc NN cord-010092-uftc8inx 5186 27 ) ) -RRB- cord-010092-uftc8inx 5186 28 device device NN cord-010092-uftc8inx 5186 29 . . . cord-010092-uftc8inx 5187 1 Donors donor NNS cord-010092-uftc8inx 5187 2 with with IN cord-010092-uftc8inx 5187 3 Hb Hb NNP cord-010092-uftc8inx 5187 4 < < XX cord-010092-uftc8inx 5187 5 125 125 CD cord-010092-uftc8inx 5187 6 g g NN cord-010092-uftc8inx 5187 7 / / SYM cord-010092-uftc8inx 5187 8 l l NN cord-010092-uftc8inx 5187 9 for for IN cord-010092-uftc8inx 5187 10 females female NNS cord-010092-uftc8inx 5187 11 or or CC cord-010092-uftc8inx 5187 12 < < XX cord-010092-uftc8inx 5187 13 135 135 CD cord-010092-uftc8inx 5187 14 g g NN cord-010092-uftc8inx 5187 15 / / SYM cord-010092-uftc8inx 5187 16 l l NN cord-010092-uftc8inx 5187 17 for for IN cord-010092-uftc8inx 5187 18 males male NNS cord-010092-uftc8inx 5187 19 or or CC cord-010092-uftc8inx 5187 20 with with IN cord-010092-uftc8inx 5187 21 a a DT cord-010092-uftc8inx 5187 22 decrease decrease NN cord-010092-uftc8inx 5187 23 > > XX cord-010092-uftc8inx 5188 1 20 20 CD cord-010092-uftc8inx 5188 2 g g NN cord-010092-uftc8inx 5188 3 / / SYM cord-010092-uftc8inx 5188 4 l l NN cord-010092-uftc8inx 5188 5 from from IN cord-010092-uftc8inx 5188 6 latest late JJS cord-010092-uftc8inx 5188 7 donation donation NN cord-010092-uftc8inx 5188 8 were be VBD cord-010092-uftc8inx 5188 9 included include VBN cord-010092-uftc8inx 5188 10 in in IN cord-010092-uftc8inx 5188 11 the the DT cord-010092-uftc8inx 5188 12 study study NN cord-010092-uftc8inx 5188 13 . . . cord-010092-uftc8inx 5189 1 In in IN cord-010092-uftc8inx 5189 2 the the DT cord-010092-uftc8inx 5189 3 study study NN cord-010092-uftc8inx 5189 4 group group NN cord-010092-uftc8inx 5189 5 , , , cord-010092-uftc8inx 5189 6 a a DT cord-010092-uftc8inx 5189 7 venous venous JJ cord-010092-uftc8inx 5189 8 blood blood NN cord-010092-uftc8inx 5189 9 sample sample NN cord-010092-uftc8inx 5189 10 was be VBD cord-010092-uftc8inx 5189 11 collected collect VBN cord-010092-uftc8inx 5189 12 for for IN cord-010092-uftc8inx 5189 13 Hb Hb NNP cord-010092-uftc8inx 5189 14 measurement measurement NN cord-010092-uftc8inx 5189 15 with with IN cord-010092-uftc8inx 5189 16 the the DT cord-010092-uftc8inx 5189 17 POC POC NNP cord-010092-uftc8inx 5189 18 device device NN cord-010092-uftc8inx 5189 19 at at IN cord-010092-uftc8inx 5189 20 the the DT cord-010092-uftc8inx 5189 21 donation donation NN cord-010092-uftc8inx 5189 22 site site NN cord-010092-uftc8inx 5189 23 . . . cord-010092-uftc8inx 5190 1 Donation donation NN cord-010092-uftc8inx 5190 2 eligibility eligibility NN cord-010092-uftc8inx 5190 3 was be VBD cord-010092-uftc8inx 5190 4 based base VBN cord-010092-uftc8inx 5190 5 on on IN cord-010092-uftc8inx 5190 6 this this DT cord-010092-uftc8inx 5190 7 Hb Hb NNP cord-010092-uftc8inx 5190 8 result result NN cord-010092-uftc8inx 5190 9 . . . cord-010092-uftc8inx 5191 1 Venous venous JJ cord-010092-uftc8inx 5191 2 Hb Hb NNP cord-010092-uftc8inx 5191 3 was be VBD cord-010092-uftc8inx 5191 4 also also RB cord-010092-uftc8inx 5191 5 determined determine VBN cord-010092-uftc8inx 5191 6 with with IN cord-010092-uftc8inx 5191 7 a a DT cord-010092-uftc8inx 5191 8 hematology hematology NN cord-010092-uftc8inx 5191 9 analyzer analyzer NN cord-010092-uftc8inx 5191 10 ( ( -LRB- cord-010092-uftc8inx 5191 11 Sysmex Sysmex NNP cord-010092-uftc8inx 5191 12 XN XN NNP cord-010092-uftc8inx 5191 13 , , , cord-010092-uftc8inx 5191 14 Sysmex Sysmex NNP cord-010092-uftc8inx 5191 15 Co. Co. NNP cord-010092-uftc8inx 5191 16 ) ) -RRB- cord-010092-uftc8inx 5191 17 . . . cord-010092-uftc8inx 5192 1 The the DT cord-010092-uftc8inx 5192 2 Blood Blood NNP cord-010092-uftc8inx 5192 3 Service Service NNP cord-010092-uftc8inx 5192 4 's 's POS cord-010092-uftc8inx 5192 5 current current JJ cord-010092-uftc8inx 5192 6 workflow workflow NN cord-010092-uftc8inx 5192 7 served serve VBD cord-010092-uftc8inx 5192 8 as as IN cord-010092-uftc8inx 5192 9 the the DT cord-010092-uftc8inx 5192 10 control control NN cord-010092-uftc8inx 5192 11 group group NN cord-010092-uftc8inx 5192 12 : : : cord-010092-uftc8inx 5192 13 two two CD cord-010092-uftc8inx 5192 14 more more JJR cord-010092-uftc8inx 5192 15 skin skin NN cord-010092-uftc8inx 5192 16 - - HYPH cord-010092-uftc8inx 5192 17 prick prick NN cord-010092-uftc8inx 5192 18 samples sample NNS cord-010092-uftc8inx 5192 19 were be VBD cord-010092-uftc8inx 5192 20 collected collect VBN cord-010092-uftc8inx 5192 21 and and CC cord-010092-uftc8inx 5192 22 the the DT cord-010092-uftc8inx 5192 23 donor donor NN cord-010092-uftc8inx 5192 24 's 's POS cord-010092-uftc8inx 5192 25 final final JJ cord-010092-uftc8inx 5192 26 Hb Hb NNP cord-010092-uftc8inx 5192 27 and and CC cord-010092-uftc8inx 5192 28 donation donation NN cord-010092-uftc8inx 5192 29 eligibility eligibility NN cord-010092-uftc8inx 5192 30 assessed assess VBN cord-010092-uftc8inx 5192 31 with with IN cord-010092-uftc8inx 5192 32 an an DT cord-010092-uftc8inx 5192 33 algorithm algorithm NN cord-010092-uftc8inx 5192 34 based base VBN cord-010092-uftc8inx 5192 35 on on IN cord-010092-uftc8inx 5192 36 all all DT cord-010092-uftc8inx 5192 37 three three CD cord-010092-uftc8inx 5192 38 skin skin NN cord-010092-uftc8inx 5192 39 - - HYPH cord-010092-uftc8inx 5192 40 prick prick NN cord-010092-uftc8inx 5192 41 Hb Hb NNP cord-010092-uftc8inx 5192 42 results result NNS cord-010092-uftc8inx 5192 43 . . . cord-010092-uftc8inx 5193 1 Results result NNS cord-010092-uftc8inx 5193 2 : : : cord-010092-uftc8inx 5194 1 In in IN cord-010092-uftc8inx 5194 2 the the DT cord-010092-uftc8inx 5194 3 study study NN cord-010092-uftc8inx 5194 4 ( ( -LRB- cord-010092-uftc8inx 5194 5 n n NN cord-010092-uftc8inx 5194 6 = = SYM cord-010092-uftc8inx 5194 7 305 305 CD cord-010092-uftc8inx 5194 8 ) ) -RRB- cord-010092-uftc8inx 5194 9 and and CC cord-010092-uftc8inx 5194 10 control control NN cord-010092-uftc8inx 5194 11 ( ( -LRB- cord-010092-uftc8inx 5194 12 n n NN cord-010092-uftc8inx 5194 13 = = SYM cord-010092-uftc8inx 5194 14 331 331 CD cord-010092-uftc8inx 5194 15 ) ) -RRB- cord-010092-uftc8inx 5194 16 groups group NNS cord-010092-uftc8inx 5194 17 , , , cord-010092-uftc8inx 5194 18 the the DT cord-010092-uftc8inx 5194 19 proportion proportion NN cord-010092-uftc8inx 5194 20 of of IN cord-010092-uftc8inx 5194 21 male male JJ cord-010092-uftc8inx 5194 22 donors donor NNS cord-010092-uftc8inx 5194 23 ( ( -LRB- cord-010092-uftc8inx 5194 24 27 27 CD cord-010092-uftc8inx 5194 25 % % NN cord-010092-uftc8inx 5194 26 and and CC cord-010092-uftc8inx 5194 27 26 26 CD cord-010092-uftc8inx 5194 28 % % NN cord-010092-uftc8inx 5194 29 ) ) -RRB- cord-010092-uftc8inx 5194 30 and and CC cord-010092-uftc8inx 5194 31 the the DT cord-010092-uftc8inx 5194 32 mean mean JJ cord-010092-uftc8inx 5194 33 initial initial JJ cord-010092-uftc8inx 5194 34 skin skin NN cord-010092-uftc8inx 5194 35 - - HYPH cord-010092-uftc8inx 5194 36 prick prick NN cord-010092-uftc8inx 5194 37 Hb Hb NNP cord-010092-uftc8inx 5194 38 ( ( -LRB- cord-010092-uftc8inx 5194 39 122 122 CD cord-010092-uftc8inx 5194 40 g g NN cord-010092-uftc8inx 5194 41 / / SYM cord-010092-uftc8inx 5194 42 l l NN cord-010092-uftc8inx 5194 43 and and CC cord-010092-uftc8inx 5194 44 123 123 CD cord-010092-uftc8inx 5194 45 g g NN cord-010092-uftc8inx 5194 46 / / SYM cord-010092-uftc8inx 5194 47 l l NN cord-010092-uftc8inx 5194 48 ) ) -RRB- cord-010092-uftc8inx 5194 49 were be VBD cord-010092-uftc8inx 5194 50 similar similar JJ cord-010092-uftc8inx 5194 51 . . . cord-010092-uftc8inx 5195 1 Significantly significantly RB cord-010092-uftc8inx 5195 2 less less JJR cord-010092-uftc8inx 5195 3 donors donor NNS cord-010092-uftc8inx 5195 4 were be VBD cord-010092-uftc8inx 5195 5 deferred defer VBN cord-010092-uftc8inx 5195 6 from from IN cord-010092-uftc8inx 5195 7 donation donation NN cord-010092-uftc8inx 5195 8 in in IN cord-010092-uftc8inx 5195 9 the the DT cord-010092-uftc8inx 5195 10 study study NN cord-010092-uftc8inx 5195 11 group group NN cord-010092-uftc8inx 5195 12 ( ( -LRB- cord-010092-uftc8inx 5195 13 40 40 CD cord-010092-uftc8inx 5195 14 % % NN cord-010092-uftc8inx 5195 15 ) ) -RRB- cord-010092-uftc8inx 5195 16 than than IN cord-010092-uftc8inx 5195 17 in in IN cord-010092-uftc8inx 5195 18 the the DT cord-010092-uftc8inx 5195 19 control control NN cord-010092-uftc8inx 5195 20 group group NN cord-010092-uftc8inx 5195 21 ( ( -LRB- cord-010092-uftc8inx 5195 22 51 51 CD cord-010092-uftc8inx 5195 23 % % NN cord-010092-uftc8inx 5195 24 ; ; : cord-010092-uftc8inx 5195 25 Chi Chi NNP cord-010092-uftc8inx 5195 26 - - HYPH cord-010092-uftc8inx 5195 27 square square JJ cord-010092-uftc8inx 5195 28 test test NN cord-010092-uftc8inx 5195 29 P p NN cord-010092-uftc8inx 5195 30 = = SYM cord-010092-uftc8inx 5195 31 0.004 0.004 CD cord-010092-uftc8inx 5195 32 ) ) -RRB- cord-010092-uftc8inx 5195 33 . . . cord-010092-uftc8inx 5196 1 The the DT cord-010092-uftc8inx 5196 2 mean mean JJ cord-010092-uftc8inx 5196 3 difference difference NN cord-010092-uftc8inx 5196 4 in in IN cord-010092-uftc8inx 5196 5 venous venous JJ cord-010092-uftc8inx 5196 6 Hb Hb NNP cord-010092-uftc8inx 5196 7 with with IN cord-010092-uftc8inx 5196 8 the the DT cord-010092-uftc8inx 5196 9 POC POC NNP cord-010092-uftc8inx 5196 10 device device NN cord-010092-uftc8inx 5196 11 versus versus IN cord-010092-uftc8inx 5196 12 the the DT cord-010092-uftc8inx 5196 13 hematology hematology NN cord-010092-uftc8inx 5196 14 analyzer analyzer NN cord-010092-uftc8inx 5196 15 was be VBD cord-010092-uftc8inx 5196 16 À3 à3 CD cord-010092-uftc8inx 5196 17 g g NN cord-010092-uftc8inx 5196 18 / / SYM cord-010092-uftc8inx 5196 19 l l NN cord-010092-uftc8inx 5196 20 ( ( -LRB- cord-010092-uftc8inx 5196 21 range range NNP cord-010092-uftc8inx 5196 22 À12 À12 NNP cord-010092-uftc8inx 5196 23 to to IN cord-010092-uftc8inx 5196 24 + + SYM cord-010092-uftc8inx 5196 25 6 6 CD cord-010092-uftc8inx 5196 26 g g NN cord-010092-uftc8inx 5196 27 / / SYM cord-010092-uftc8inx 5196 28 l l NN cord-010092-uftc8inx 5196 29 ) ) -RRB- cord-010092-uftc8inx 5196 30 . . . cord-010092-uftc8inx 5197 1 Two two CD cord-010092-uftc8inx 5197 2 donors donor NNS cord-010092-uftc8inx 5197 3 were be VBD cord-010092-uftc8inx 5197 4 incorrectly incorrectly RB cord-010092-uftc8inx 5197 5 accepted accept VBN cord-010092-uftc8inx 5197 6 based base VBN cord-010092-uftc8inx 5197 7 on on IN cord-010092-uftc8inx 5197 8 venous venous JJ cord-010092-uftc8inx 5197 9 sample sample NN cord-010092-uftc8inx 5197 10 POC poc NN cord-010092-uftc8inx 5197 11 result result NN cord-010092-uftc8inx 5197 12 ; ; : cord-010092-uftc8inx 5197 13 however however RB cord-010092-uftc8inx 5197 14 , , , cord-010092-uftc8inx 5197 15 in in IN cord-010092-uftc8inx 5197 16 both both DT cord-010092-uftc8inx 5197 17 , , , cord-010092-uftc8inx 5197 18 Hb Hb NNP cord-010092-uftc8inx 5197 19 measured measure VBD cord-010092-uftc8inx 5197 20 with with IN cord-010092-uftc8inx 5197 21 the the DT cord-010092-uftc8inx 5197 22 hematology hematology NN cord-010092-uftc8inx 5197 23 analyzer analyzer NN cord-010092-uftc8inx 5197 24 was be VBD cord-010092-uftc8inx 5197 25 only only RB cord-010092-uftc8inx 5197 26 1 1 CD cord-010092-uftc8inx 5197 27 g g NN cord-010092-uftc8inx 5197 28 / / SYM cord-010092-uftc8inx 5197 29 l l NN cord-010092-uftc8inx 5197 30 below below IN cord-010092-uftc8inx 5197 31 the the DT cord-010092-uftc8inx 5197 32 limit limit NN cord-010092-uftc8inx 5197 33 of of IN cord-010092-uftc8inx 5197 34 donation donation NN cord-010092-uftc8inx 5197 35 eligibility eligibility NN cord-010092-uftc8inx 5197 36 ( ( -LRB- cord-010092-uftc8inx 5197 37 124 124 CD cord-010092-uftc8inx 5197 38 g g NN cord-010092-uftc8inx 5197 39 / / SYM cord-010092-uftc8inx 5197 40 l l NN cord-010092-uftc8inx 5197 41 for for IN cord-010092-uftc8inx 5197 42 a a DT cord-010092-uftc8inx 5197 43 female female NN cord-010092-uftc8inx 5197 44 and and CC cord-010092-uftc8inx 5197 45 134 134 CD cord-010092-uftc8inx 5197 46 g g NN cord-010092-uftc8inx 5197 47 / / SYM cord-010092-uftc8inx 5197 48 l l NN cord-010092-uftc8inx 5197 49 for for IN cord-010092-uftc8inx 5197 50 a a DT cord-010092-uftc8inx 5197 51 male male NN cord-010092-uftc8inx 5197 52 ) ) -RRB- cord-010092-uftc8inx 5197 53 . . . cord-010092-uftc8inx 5198 1 Interestingly interestingly RB cord-010092-uftc8inx 5198 2 , , , cord-010092-uftc8inx 5198 3 a a DT cord-010092-uftc8inx 5198 4 further further JJ cord-010092-uftc8inx 5198 5 33 33 CD cord-010092-uftc8inx 5198 6 donors donor NNS cord-010092-uftc8inx 5198 7 ( ( -LRB- cord-010092-uftc8inx 5198 8 27 27 CD cord-010092-uftc8inx 5198 9 % % NN cord-010092-uftc8inx 5198 10 of of IN cord-010092-uftc8inx 5198 11 all all DT cord-010092-uftc8inx 5198 12 deferred defer VBN cord-010092-uftc8inx 5198 13 in in IN cord-010092-uftc8inx 5198 14 the the DT cord-010092-uftc8inx 5198 15 study study NN cord-010092-uftc8inx 5198 16 group group NN cord-010092-uftc8inx 5198 17 ) ) -RRB- cord-010092-uftc8inx 5198 18 would would MD cord-010092-uftc8inx 5198 19 have have VB cord-010092-uftc8inx 5198 20 been be VBN cord-010092-uftc8inx 5198 21 eligible eligible JJ cord-010092-uftc8inx 5198 22 for for IN cord-010092-uftc8inx 5198 23 donation donation NN cord-010092-uftc8inx 5198 24 based base VBN cord-010092-uftc8inx 5198 25 on on IN cord-010092-uftc8inx 5198 26 the the DT cord-010092-uftc8inx 5198 27 hematology hematology NN cord-010092-uftc8inx 5198 28 analyzer analyzer NN cord-010092-uftc8inx 5198 29 result result NN cord-010092-uftc8inx 5198 30 . . . cord-010092-uftc8inx 5199 1 Summary Summary NNP cord-010092-uftc8inx 5199 2 / / SYM cord-010092-uftc8inx 5199 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 5199 4 : : : cord-010092-uftc8inx 5200 1 Utilizing utilize VBG cord-010092-uftc8inx 5200 2 a a DT cord-010092-uftc8inx 5200 3 venous venous JJ cord-010092-uftc8inx 5200 4 blood blood NN cord-010092-uftc8inx 5200 5 sample sample NN cord-010092-uftc8inx 5200 6 for for IN cord-010092-uftc8inx 5200 7 second second JJ cord-010092-uftc8inx 5200 8 - - HYPH cord-010092-uftc8inx 5200 9 line line NN cord-010092-uftc8inx 5200 10 screening screening NN cord-010092-uftc8inx 5200 11 of of IN cord-010092-uftc8inx 5200 12 donors donor NNS cord-010092-uftc8inx 5200 13 failing fail VBG cord-010092-uftc8inx 5200 14 the the DT cord-010092-uftc8inx 5200 15 initial initial JJ cord-010092-uftc8inx 5200 16 skin skin NN cord-010092-uftc8inx 5200 17 - - HYPH cord-010092-uftc8inx 5200 18 prick prick NN cord-010092-uftc8inx 5200 19 Hb Hb NNP cord-010092-uftc8inx 5200 20 test test NN cord-010092-uftc8inx 5200 21 significantly significantly RB cord-010092-uftc8inx 5200 22 decreased decrease VBD cord-010092-uftc8inx 5200 23 low low JJ cord-010092-uftc8inx 5200 24 Hb Hb NNP cord-010092-uftc8inx 5200 25 deferrals deferral NNS cord-010092-uftc8inx 5200 26 without without IN cord-010092-uftc8inx 5200 27 compromising compromise VBG cord-010092-uftc8inx 5200 28 donor donor NN cord-010092-uftc8inx 5200 29 health health NN cord-010092-uftc8inx 5200 30 . . . cord-010092-uftc8inx 5201 1 Blood blood NN cord-010092-uftc8inx 5201 2 donors donor NNS cord-010092-uftc8inx 5201 3 ' ' POS cord-010092-uftc8inx 5201 4 and and CC cord-010092-uftc8inx 5201 5 Blood Blood NNP cord-010092-uftc8inx 5201 6 Service Service NNP cord-010092-uftc8inx 5201 7 nurses nurse NNS cord-010092-uftc8inx 5201 8 ' ' POS cord-010092-uftc8inx 5201 9 reactions reaction NNS cord-010092-uftc8inx 5201 10 to to IN cord-010092-uftc8inx 5201 11 the the DT cord-010092-uftc8inx 5201 12 new new JJ cord-010092-uftc8inx 5201 13 workflow workflow NN cord-010092-uftc8inx 5201 14 have have VBP cord-010092-uftc8inx 5201 15 been be VBN cord-010092-uftc8inx 5201 16 favorable favorable JJ cord-010092-uftc8inx 5201 17 . . . cord-010092-uftc8inx 5202 1 We -PRON- PRP cord-010092-uftc8inx 5202 2 conclude conclude VBP cord-010092-uftc8inx 5202 3 that that IN cord-010092-uftc8inx 5202 4 valuable valuable JJ cord-010092-uftc8inx 5202 5 donations donation NNS cord-010092-uftc8inx 5202 6 can can MD cord-010092-uftc8inx 5202 7 be be VB cord-010092-uftc8inx 5202 8 recovered recover VBN cord-010092-uftc8inx 5202 9 and and CC cord-010092-uftc8inx 5202 10 donor donor NN cord-010092-uftc8inx 5202 11 satisfaction satisfaction NN cord-010092-uftc8inx 5202 12 increased increase VBN cord-010092-uftc8inx 5202 13 by by IN cord-010092-uftc8inx 5202 14 implementing implement VBG cord-010092-uftc8inx 5202 15 a a DT cord-010092-uftc8inx 5202 16 second second JJ cord-010092-uftc8inx 5202 17 - - HYPH cord-010092-uftc8inx 5202 18 line line NN cord-010092-uftc8inx 5202 19 Hb Hb NNP cord-010092-uftc8inx 5202 20 screening screening NN cord-010092-uftc8inx 5202 21 model model NN cord-010092-uftc8inx 5202 22 utilizing utilize VBG cord-010092-uftc8inx 5202 23 venous venous JJ cord-010092-uftc8inx 5202 24 sample sample NN cord-010092-uftc8inx 5202 25 analysis analysis NN cord-010092-uftc8inx 5202 26 at at IN cord-010092-uftc8inx 5202 27 the the DT cord-010092-uftc8inx 5202 28 donation donation NN cord-010092-uftc8inx 5202 29 site site NN cord-010092-uftc8inx 5202 30 . . . cord-010092-uftc8inx 5203 1 Background background NN cord-010092-uftc8inx 5203 2 : : : cord-010092-uftc8inx 5204 1 There there EX cord-010092-uftc8inx 5204 2 is be VBZ cord-010092-uftc8inx 5204 3 a a DT cord-010092-uftc8inx 5204 4 paucity paucity NN cord-010092-uftc8inx 5204 5 of of IN cord-010092-uftc8inx 5204 6 literature literature NN cord-010092-uftc8inx 5204 7 on on IN cord-010092-uftc8inx 5204 8 haemoglobin haemoglobin NN cord-010092-uftc8inx 5204 9 ( ( -LRB- cord-010092-uftc8inx 5204 10 Hb Hb NNP cord-010092-uftc8inx 5204 11 ) ) -RRB- cord-010092-uftc8inx 5204 12 reference reference NN cord-010092-uftc8inx 5204 13 values value NNS cord-010092-uftc8inx 5204 14 for for IN cord-010092-uftc8inx 5204 15 adults adult NNS cord-010092-uftc8inx 5204 16 above above IN cord-010092-uftc8inx 5204 17 60 60 CD cord-010092-uftc8inx 5204 18 years year NNS cord-010092-uftc8inx 5204 19 of of IN cord-010092-uftc8inx 5204 20 age age NN cord-010092-uftc8inx 5204 21 . . . cord-010092-uftc8inx 5205 1 This this DT cord-010092-uftc8inx 5205 2 age age NN cord-010092-uftc8inx 5205 3 group group NN cord-010092-uftc8inx 5205 4 has have VBZ cord-010092-uftc8inx 5205 5 been be VBN cord-010092-uftc8inx 5205 6 reported report VBN cord-010092-uftc8inx 5205 7 to to TO cord-010092-uftc8inx 5205 8 use use VB cord-010092-uftc8inx 5205 9 up up RP cord-010092-uftc8inx 5205 10 to to TO cord-010092-uftc8inx 5205 11 50 50 CD cord-010092-uftc8inx 5205 12 % % NN cord-010092-uftc8inx 5205 13 the the DT cord-010092-uftc8inx 5205 14 blood blood NN cord-010092-uftc8inx 5205 15 supply supply NN cord-010092-uftc8inx 5205 16 . . . cord-010092-uftc8inx 5206 1 Some some DT cord-010092-uftc8inx 5206 2 studies study NNS cord-010092-uftc8inx 5206 3 report report VBP cord-010092-uftc8inx 5206 4 a a DT cord-010092-uftc8inx 5206 5 decline decline NN cord-010092-uftc8inx 5206 6 of of IN cord-010092-uftc8inx 5206 7 mean mean JJ cord-010092-uftc8inx 5206 8 Hb Hb NNP cord-010092-uftc8inx 5206 9 with with IN cord-010092-uftc8inx 5206 10 age age NN cord-010092-uftc8inx 5206 11 , , , cord-010092-uftc8inx 5206 12 but but CC cord-010092-uftc8inx 5206 13 others other NNS cord-010092-uftc8inx 5206 14 have have VBP cord-010092-uftc8inx 5206 15 found find VBN cord-010092-uftc8inx 5206 16 no no DT cord-010092-uftc8inx 5206 17 change change NN cord-010092-uftc8inx 5206 18 with with IN cord-010092-uftc8inx 5206 19 age age NN cord-010092-uftc8inx 5206 20 . . . cord-010092-uftc8inx 5207 1 Conflicting conflicting JJ cord-010092-uftc8inx 5207 2 findings finding NNS cord-010092-uftc8inx 5207 3 of of IN cord-010092-uftc8inx 5207 4 Hb Hb NNP cord-010092-uftc8inx 5207 5 levels level NNS cord-010092-uftc8inx 5207 6 in in IN cord-010092-uftc8inx 5207 7 the the DT cord-010092-uftc8inx 5207 8 healthy healthy JJ cord-010092-uftc8inx 5207 9 elderly elderly JJ cord-010092-uftc8inx 5207 10 population population NN cord-010092-uftc8inx 5207 11 may may MD cord-010092-uftc8inx 5207 12 be be VB cord-010092-uftc8inx 5207 13 associated associate VBN cord-010092-uftc8inx 5207 14 with with IN cord-010092-uftc8inx 5207 15 challenges challenge NNS cord-010092-uftc8inx 5207 16 in in IN cord-010092-uftc8inx 5207 17 accessing access VBG cord-010092-uftc8inx 5207 18 data datum NNS cord-010092-uftc8inx 5207 19 from from IN cord-010092-uftc8inx 5207 20 healthy healthy JJ cord-010092-uftc8inx 5207 21 older old JJR cord-010092-uftc8inx 5207 22 adults adult NNS cord-010092-uftc8inx 5207 23 , , , cord-010092-uftc8inx 5207 24 small small JJ cord-010092-uftc8inx 5207 25 sample sample NN cord-010092-uftc8inx 5207 26 sizes size NNS cord-010092-uftc8inx 5207 27 , , , cord-010092-uftc8inx 5207 28 selection selection NN cord-010092-uftc8inx 5207 29 bias bias NN cord-010092-uftc8inx 5207 30 and and CC cord-010092-uftc8inx 5207 31 recent recent JJ cord-010092-uftc8inx 5207 32 health health NN cord-010092-uftc8inx 5207 33 population population NN cord-010092-uftc8inx 5207 34 data datum NNS cord-010092-uftc8inx 5207 35 . . . cord-010092-uftc8inx 5208 1 To to TO cord-010092-uftc8inx 5208 2 donate donate VB cord-010092-uftc8inx 5208 3 blood blood NN cord-010092-uftc8inx 5208 4 , , , cord-010092-uftc8inx 5208 5 each each DT cord-010092-uftc8inx 5208 6 individual individual NN cord-010092-uftc8inx 5208 7 is be VBZ cord-010092-uftc8inx 5208 8 assessed assess VBN cord-010092-uftc8inx 5208 9 as as IN cord-010092-uftc8inx 5208 10 ' ' `` cord-010092-uftc8inx 5208 11 healthy healthy JJ cord-010092-uftc8inx 5208 12 ' ' '' cord-010092-uftc8inx 5208 13 and and CC cord-010092-uftc8inx 5208 14 must must MD cord-010092-uftc8inx 5208 15 meet meet VB cord-010092-uftc8inx 5208 16 the the DT cord-010092-uftc8inx 5208 17 minimum minimum JJ cord-010092-uftc8inx 5208 18 Hb Hb NNP cord-010092-uftc8inx 5208 19 criteria criterion NNS cord-010092-uftc8inx 5208 20 . . . cord-010092-uftc8inx 5209 1 However however RB cord-010092-uftc8inx 5209 2 , , , cord-010092-uftc8inx 5209 3 the the DT cord-010092-uftc8inx 5209 4 Hb Hb NNP cord-010092-uftc8inx 5209 5 criteria criterion NNS cord-010092-uftc8inx 5209 6 across across IN cord-010092-uftc8inx 5209 7 countries country NNS cord-010092-uftc8inx 5209 8 vary vary VBP cord-010092-uftc8inx 5209 9 and and CC cord-010092-uftc8inx 5209 10 many many JJ cord-010092-uftc8inx 5209 11 blood blood NN cord-010092-uftc8inx 5209 12 collection collection NN cord-010092-uftc8inx 5209 13 services service NNS cord-010092-uftc8inx 5209 14 have have VBP cord-010092-uftc8inx 5209 15 an an DT cord-010092-uftc8inx 5209 16 upper upper JJ cord-010092-uftc8inx 5209 17 age age NN cord-010092-uftc8inx 5209 18 limit limit NN cord-010092-uftc8inx 5209 19 for for IN cord-010092-uftc8inx 5209 20 donors donor NNS cord-010092-uftc8inx 5209 21 . . . cord-010092-uftc8inx 5210 1 As as IN cord-010092-uftc8inx 5210 2 many many JJ cord-010092-uftc8inx 5210 3 populations population NNS cord-010092-uftc8inx 5210 4 around around IN cord-010092-uftc8inx 5210 5 world world NN cord-010092-uftc8inx 5210 6 are be VBP cord-010092-uftc8inx 5210 7 aging age VBG cord-010092-uftc8inx 5210 8 , , , cord-010092-uftc8inx 5210 9 restricting restrict VBG cord-010092-uftc8inx 5210 10 the the DT cord-010092-uftc8inx 5210 11 upper upper JJ cord-010092-uftc8inx 5210 12 age age NN cord-010092-uftc8inx 5210 13 limit limit NN cord-010092-uftc8inx 5210 14 for for IN cord-010092-uftc8inx 5210 15 blood blood NN cord-010092-uftc8inx 5210 16 donation donation NN cord-010092-uftc8inx 5210 17 may may MD cord-010092-uftc8inx 5210 18 potentially potentially RB cord-010092-uftc8inx 5210 19 affect affect VB cord-010092-uftc8inx 5210 20 the the DT cord-010092-uftc8inx 5210 21 size size NN cord-010092-uftc8inx 5210 22 of of IN cord-010092-uftc8inx 5210 23 the the DT cord-010092-uftc8inx 5210 24 donor donor NN cord-010092-uftc8inx 5210 25 pool pool NN cord-010092-uftc8inx 5210 26 and and CC cord-010092-uftc8inx 5210 27 consequently consequently RB cord-010092-uftc8inx 5210 28 the the DT cord-010092-uftc8inx 5210 29 nation nation NN cord-010092-uftc8inx 5210 30 's 's POS cord-010092-uftc8inx 5210 31 blood blood NN cord-010092-uftc8inx 5210 32 supply supply NN cord-010092-uftc8inx 5210 33 . . . cord-010092-uftc8inx 5211 1 Aims aim VBZ cord-010092-uftc8inx 5211 2 : : : cord-010092-uftc8inx 5212 1 To to TO cord-010092-uftc8inx 5212 2 explore explore VB cord-010092-uftc8inx 5212 3 the the DT cord-010092-uftc8inx 5212 4 Hb Hb NNP cord-010092-uftc8inx 5212 5 levels level NNS cord-010092-uftc8inx 5212 6 of of IN cord-010092-uftc8inx 5212 7 healthy healthy JJ cord-010092-uftc8inx 5212 8 older old JJR cord-010092-uftc8inx 5212 9 adults adult NNS cord-010092-uftc8inx 5212 10 , , , cord-010092-uftc8inx 5212 11 through through IN cord-010092-uftc8inx 5212 12 a a DT cord-010092-uftc8inx 5212 13 multi multi JJ cord-010092-uftc8inx 5212 14 - - JJ cord-010092-uftc8inx 5212 15 centre centre JJ cord-010092-uftc8inx 5212 16 retrospective retrospective JJ cord-010092-uftc8inx 5212 17 observational observational JJ cord-010092-uftc8inx 5212 18 study study NN cord-010092-uftc8inx 5212 19 of of IN cord-010092-uftc8inx 5212 20 blood blood NN cord-010092-uftc8inx 5212 21 donors donor NNS cord-010092-uftc8inx 5212 22 aged age VBN cord-010092-uftc8inx 5212 23 60 60 CD cord-010092-uftc8inx 5212 24 years year NNS cord-010092-uftc8inx 5212 25 or or CC cord-010092-uftc8inx 5212 26 older old JJR cord-010092-uftc8inx 5212 27 . . . cord-010092-uftc8inx 5213 1 Methods method NNS cord-010092-uftc8inx 5213 2 : : : cord-010092-uftc8inx 5213 3 Over over IN cord-010092-uftc8inx 5213 4 a a DT cord-010092-uftc8inx 5213 5 one one CD cord-010092-uftc8inx 5213 6 - - HYPH cord-010092-uftc8inx 5213 7 year year NN cord-010092-uftc8inx 5213 8 period period NN cord-010092-uftc8inx 5213 9 , , , cord-010092-uftc8inx 5213 10 Hb Hb NNP cord-010092-uftc8inx 5213 11 values value NNS cord-010092-uftc8inx 5213 12 were be VBD cord-010092-uftc8inx 5213 13 collected collect VBN cord-010092-uftc8inx 5213 14 from from IN cord-010092-uftc8inx 5213 15 blood blood NN cord-010092-uftc8inx 5213 16 donors donor NNS cord-010092-uftc8inx 5213 17 aged age VBN cord-010092-uftc8inx 5213 18 ≥ ≥ CD cord-010092-uftc8inx 5213 19 60 60 CD cord-010092-uftc8inx 5213 20 years year NNS cord-010092-uftc8inx 5213 21 from from IN cord-010092-uftc8inx 5213 22 blood blood NN cord-010092-uftc8inx 5213 23 centres centre NNS cord-010092-uftc8inx 5213 24 of of IN cord-010092-uftc8inx 5213 25 four four CD cord-010092-uftc8inx 5213 26 countries country NNS cord-010092-uftc8inx 5213 27 . . . cord-010092-uftc8inx 5214 1 The the DT cord-010092-uftc8inx 5214 2 estimated estimate VBN cord-010092-uftc8inx 5214 3 proportion proportion NN cord-010092-uftc8inx 5214 4 of of IN cord-010092-uftc8inx 5214 5 blood blood NN cord-010092-uftc8inx 5214 6 donors donor NNS cord-010092-uftc8inx 5214 7 aged age VBN cord-010092-uftc8inx 5214 8 ≥ ≥ CD cord-010092-uftc8inx 5214 9 60 60 CD cord-010092-uftc8inx 5214 10 years year NNS cord-010092-uftc8inx 5214 11 old old JJ cord-010092-uftc8inx 5214 12 for for IN cord-010092-uftc8inx 5214 13 each each DT cord-010092-uftc8inx 5214 14 country country NN cord-010092-uftc8inx 5214 15 was be VBD cord-010092-uftc8inx 5214 16 0.81 0.81 CD cord-010092-uftc8inx 5214 17 % % NN cord-010092-uftc8inx 5214 18 in in IN cord-010092-uftc8inx 5214 19 South South NNP cord-010092-uftc8inx 5214 20 Korea Korea NNP cord-010092-uftc8inx 5214 21 ( ( -LRB- cord-010092-uftc8inx 5214 22 SK SK NNP cord-010092-uftc8inx 5214 23 ) ) -RRB- cord-010092-uftc8inx 5214 24 ; ; : cord-010092-uftc8inx 5214 25 2.57 2.57 CD cord-010092-uftc8inx 5214 26 % % NN cord-010092-uftc8inx 5214 27 in in IN cord-010092-uftc8inx 5214 28 Hong Hong NNP cord-010092-uftc8inx 5214 29 Kong Kong NNP cord-010092-uftc8inx 5214 30 ( ( -LRB- cord-010092-uftc8inx 5214 31 HK HK NNP cord-010092-uftc8inx 5214 32 ) ) -RRB- cord-010092-uftc8inx 5214 33 , , , cord-010092-uftc8inx 5214 34 < < NNP cord-010092-uftc8inx 5214 35 3.18 3.18 CD cord-010092-uftc8inx 5214 36 % % NN cord-010092-uftc8inx 5214 37 Indonesia Indonesia NNP cord-010092-uftc8inx 5214 38 ( ( -LRB- cord-010092-uftc8inx 5214 39 INDO INDO NNP cord-010092-uftc8inx 5214 40 ) ) -RRB- cord-010092-uftc8inx 5214 41 and and CC cord-010092-uftc8inx 5214 42 9 9 CD cord-010092-uftc8inx 5214 43 % % NN cord-010092-uftc8inx 5214 44 in in IN cord-010092-uftc8inx 5214 45 Japan Japan NNP cord-010092-uftc8inx 5214 46 ( ( -LRB- cord-010092-uftc8inx 5214 47 JAP JAP NNP cord-010092-uftc8inx 5214 48 ) ) -RRB- cord-010092-uftc8inx 5214 49 . . . cord-010092-uftc8inx 5215 1 The the DT cord-010092-uftc8inx 5215 2 minimum minimum JJ cord-010092-uftc8inx 5215 3 Hb Hb NNP cord-010092-uftc8inx 5215 4 criteria criterion NNS cord-010092-uftc8inx 5215 5 varied varied JJ cord-010092-uftc8inx 5215 6 between between IN cord-010092-uftc8inx 5215 7 each each DT cord-010092-uftc8inx 5215 8 country country NN cord-010092-uftc8inx 5215 9 and and CC cord-010092-uftc8inx 5215 10 ranged range VBD cord-010092-uftc8inx 5215 11 from from IN cord-010092-uftc8inx 5215 12 11.5 11.5 CD cord-010092-uftc8inx 5215 13 - - SYM cord-010092-uftc8inx 5215 14 12.5 12.5 CD cord-010092-uftc8inx 5215 15 g g NN cord-010092-uftc8inx 5215 16 / / SYM cord-010092-uftc8inx 5215 17 dL dl NN cord-010092-uftc8inx 5215 18 for for IN cord-010092-uftc8inx 5215 19 women woman NNS cord-010092-uftc8inx 5215 20 and and CC cord-010092-uftc8inx 5215 21 12.5 12.5 CD cord-010092-uftc8inx 5215 22 - - HYPH cord-010092-uftc8inx 5215 23 13.0 13.0 CD cord-010092-uftc8inx 5215 24 g g NN cord-010092-uftc8inx 5215 25 / / SYM cord-010092-uftc8inx 5215 26 dL dl NN cord-010092-uftc8inx 5215 27 for for IN cord-010092-uftc8inx 5215 28 men man NNS cord-010092-uftc8inx 5215 29 . . . cord-010092-uftc8inx 5216 1 Hb Hb NNP cord-010092-uftc8inx 5216 2 levels level NNS cord-010092-uftc8inx 5216 3 were be VBD cord-010092-uftc8inx 5216 4 determined determine VBN cord-010092-uftc8inx 5216 5 using use VBG cord-010092-uftc8inx 5216 6 point point NN cord-010092-uftc8inx 5216 7 of of IN cord-010092-uftc8inx 5216 8 care care NN cord-010092-uftc8inx 5216 9 testing testing NN cord-010092-uftc8inx 5216 10 ( ( -LRB- cord-010092-uftc8inx 5216 11 Hemocue Hemocue NNP cord-010092-uftc8inx 5216 12 , , , cord-010092-uftc8inx 5216 13 Compolab Compolab NNP cord-010092-uftc8inx 5216 14 , , , cord-010092-uftc8inx 5216 15 Hemcontrol Hemcontrol NNP cord-010092-uftc8inx 5216 16 ) ) -RRB- cord-010092-uftc8inx 5216 17 or or CC cord-010092-uftc8inx 5216 18 the the DT cord-010092-uftc8inx 5216 19 XE-2100D XE-2100D NNP cord-010092-uftc8inx 5216 20 Sysmex Sysmex NNP cord-010092-uftc8inx 5216 21 dependant dependant JJ cord-010092-uftc8inx 5216 22 on on IN cord-010092-uftc8inx 5216 23 the the DT cord-010092-uftc8inx 5216 24 country country NN cord-010092-uftc8inx 5216 25 of of IN cord-010092-uftc8inx 5216 26 origin origin NN cord-010092-uftc8inx 5216 27 . . . cord-010092-uftc8inx 5217 1 Statistical statistical JJ cord-010092-uftc8inx 5217 2 analysis analysis NN cord-010092-uftc8inx 5217 3 of of IN cord-010092-uftc8inx 5217 4 the the DT cord-010092-uftc8inx 5217 5 mean mean JJ cord-010092-uftc8inx 5217 6 , , , cord-010092-uftc8inx 5217 7 standard standard JJ cord-010092-uftc8inx 5217 8 deviation deviation NN cord-010092-uftc8inx 5217 9 and and CC cord-010092-uftc8inx 5217 10 cumulative cumulative JJ cord-010092-uftc8inx 5217 11 distribution distribution NN cord-010092-uftc8inx 5217 12 of of IN cord-010092-uftc8inx 5217 13 Hb Hb NNP cord-010092-uftc8inx 5217 14 were be VBD cord-010092-uftc8inx 5217 15 determined determine VBN cord-010092-uftc8inx 5217 16 by by IN cord-010092-uftc8inx 5217 17 gender gender NN cord-010092-uftc8inx 5217 18 and and CC cord-010092-uftc8inx 5217 19 age age NN cord-010092-uftc8inx 5217 20 . . . cord-010092-uftc8inx 5218 1 Background background NN cord-010092-uftc8inx 5218 2 : : : cord-010092-uftc8inx 5219 1 Medication medication NN cord-010092-uftc8inx 5219 2 usage usage NN cord-010092-uftc8inx 5219 3 is be VBZ cord-010092-uftc8inx 5219 4 assessed assess VBN cord-010092-uftc8inx 5219 5 to to TO cord-010092-uftc8inx 5219 6 determine determine VB cord-010092-uftc8inx 5219 7 donor donor NN cord-010092-uftc8inx 5219 8 eligibility eligibility NN cord-010092-uftc8inx 5219 9 from from IN cord-010092-uftc8inx 5219 10 the the DT cord-010092-uftc8inx 5219 11 perspective perspective NN cord-010092-uftc8inx 5219 12 of of IN cord-010092-uftc8inx 5219 13 both both DT cord-010092-uftc8inx 5219 14 recipient recipient NN cord-010092-uftc8inx 5219 15 and and CC cord-010092-uftc8inx 5219 16 donor donor NN cord-010092-uftc8inx 5219 17 safety safety NN cord-010092-uftc8inx 5219 18 . . . cord-010092-uftc8inx 5220 1 Different different JJ cord-010092-uftc8inx 5220 2 time time NN cord-010092-uftc8inx 5220 3 frames frame NNS cord-010092-uftc8inx 5220 4 since since IN cord-010092-uftc8inx 5220 5 last last JJ cord-010092-uftc8inx 5220 6 taken take VBN cord-010092-uftc8inx 5220 7 apply apply VBP cord-010092-uftc8inx 5220 8 to to IN cord-010092-uftc8inx 5220 9 different different JJ cord-010092-uftc8inx 5220 10 medications medication NNS cord-010092-uftc8inx 5220 11 . . . cord-010092-uftc8inx 5221 1 Assessment assessment NN cord-010092-uftc8inx 5221 2 of of IN cord-010092-uftc8inx 5221 3 medication medication NN cord-010092-uftc8inx 5221 4 use use NN cord-010092-uftc8inx 5221 5 varies vary VBZ cord-010092-uftc8inx 5221 6 by by IN cord-010092-uftc8inx 5221 7 jurisdiction jurisdiction NN cord-010092-uftc8inx 5221 8 , , , cord-010092-uftc8inx 5221 9 but but CC cord-010092-uftc8inx 5221 10 most most JJS cord-010092-uftc8inx 5221 11 European european JJ cord-010092-uftc8inx 5221 12 centres centre NNS cord-010092-uftc8inx 5221 13 use use VBP cord-010092-uftc8inx 5221 14 multiple multiple JJ cord-010092-uftc8inx 5221 15 questions question NNS cord-010092-uftc8inx 5221 16 . . . cord-010092-uftc8inx 5222 1 These these DT cord-010092-uftc8inx 5222 2 often often RB cord-010092-uftc8inx 5222 3 include include VBP cord-010092-uftc8inx 5222 4 a a DT cord-010092-uftc8inx 5222 5 general general JJ cord-010092-uftc8inx 5222 6 question question NN cord-010092-uftc8inx 5222 7 about about IN cord-010092-uftc8inx 5222 8 recent recent JJ cord-010092-uftc8inx 5222 9 medication medication NN cord-010092-uftc8inx 5222 10 use use NN cord-010092-uftc8inx 5222 11 whereas whereas IN cord-010092-uftc8inx 5222 12 the the DT cord-010092-uftc8inx 5222 13 USA USA NNP cord-010092-uftc8inx 5222 14 does do VBZ cord-010092-uftc8inx 5222 15 not not RB cord-010092-uftc8inx 5222 16 . . . cord-010092-uftc8inx 5223 1 At at IN cord-010092-uftc8inx 5223 2 Canadian Canadian NNP cord-010092-uftc8inx 5223 3 Blood Blood NNP cord-010092-uftc8inx 5223 4 Services Services NNPS cord-010092-uftc8inx 5223 5 there there EX cord-010092-uftc8inx 5223 6 are be VBP cord-010092-uftc8inx 5223 7 6 6 CD cord-010092-uftc8inx 5223 8 medication medication NN cord-010092-uftc8inx 5223 9 questions question NNS cord-010092-uftc8inx 5223 10 on on IN cord-010092-uftc8inx 5223 11 the the DT cord-010092-uftc8inx 5223 12 Donor Donor NNP cord-010092-uftc8inx 5223 13 History history NN cord-010092-uftc8inx 5223 14 Questionnaire Questionnaire NNP cord-010092-uftc8inx 5223 15 ( ( -LRB- cord-010092-uftc8inx 5223 16 DHQ DHQ NNP cord-010092-uftc8inx 5223 17 ) ) -RRB- cord-010092-uftc8inx 5223 18 , , , cord-010092-uftc8inx 5223 19 including include VBG cord-010092-uftc8inx 5223 20 any any DT cord-010092-uftc8inx 5223 21 medication medication NN cord-010092-uftc8inx 5223 22 use use NN cord-010092-uftc8inx 5223 23 in in IN cord-010092-uftc8inx 5223 24 the the DT cord-010092-uftc8inx 5223 25 last last JJ cord-010092-uftc8inx 5223 26 3 3 CD cord-010092-uftc8inx 5223 27 days day NNS cord-010092-uftc8inx 5223 28 , , , cord-010092-uftc8inx 5223 29 vaccination vaccination NN cord-010092-uftc8inx 5223 30 and and CC cord-010092-uftc8inx 5223 31 specific specific JJ cord-010092-uftc8inx 5223 32 medications medication NNS cord-010092-uftc8inx 5223 33 over over IN cord-010092-uftc8inx 5223 34 different different JJ cord-010092-uftc8inx 5223 35 time time NN cord-010092-uftc8inx 5223 36 frames frame NNS cord-010092-uftc8inx 5223 37 ( ( -LRB- cord-010092-uftc8inx 5223 38 high high JJ cord-010092-uftc8inx 5223 39 teratogenicity teratogenicity NN cord-010092-uftc8inx 5223 40 medications medication NNS cord-010092-uftc8inx 5223 41 ) ) -RRB- cord-010092-uftc8inx 5223 42 . . . cord-010092-uftc8inx 5224 1 The the DT cord-010092-uftc8inx 5224 2 name name NN cord-010092-uftc8inx 5224 3 of of IN cord-010092-uftc8inx 5224 4 each each DT cord-010092-uftc8inx 5224 5 medication medication NN cord-010092-uftc8inx 5224 6 taken take VBN cord-010092-uftc8inx 5224 7 and and CC cord-010092-uftc8inx 5224 8 reason reason NN cord-010092-uftc8inx 5224 9 for for IN cord-010092-uftc8inx 5224 10 use use NN cord-010092-uftc8inx 5224 11 are be VBP cord-010092-uftc8inx 5224 12 documented document VBN cord-010092-uftc8inx 5224 13 by by IN cord-010092-uftc8inx 5224 14 staff staff NN cord-010092-uftc8inx 5224 15 at at IN cord-010092-uftc8inx 5224 16 each each DT cord-010092-uftc8inx 5224 17 donation donation NN cord-010092-uftc8inx 5224 18 attempt attempt NN cord-010092-uftc8inx 5224 19 . . . cord-010092-uftc8inx 5225 1 Assessment assessment NN cord-010092-uftc8inx 5225 2 of of IN cord-010092-uftc8inx 5225 3 the the DT cord-010092-uftc8inx 5225 4 frequency frequency NN cord-010092-uftc8inx 5225 5 with with IN cord-010092-uftc8inx 5225 6 which which WDT cord-010092-uftc8inx 5225 7 this this DT cord-010092-uftc8inx 5225 8 process process NN cord-010092-uftc8inx 5225 9 occurs occur VBZ cord-010092-uftc8inx 5225 10 is be VBZ cord-010092-uftc8inx 5225 11 the the DT cord-010092-uftc8inx 5225 12 first first JJ cord-010092-uftc8inx 5225 13 step step NN cord-010092-uftc8inx 5225 14 in in IN cord-010092-uftc8inx 5225 15 improving improve VBG cord-010092-uftc8inx 5225 16 efficiency efficiency NN cord-010092-uftc8inx 5225 17 of of IN cord-010092-uftc8inx 5225 18 this this DT cord-010092-uftc8inx 5225 19 aspect aspect NN cord-010092-uftc8inx 5225 20 of of IN cord-010092-uftc8inx 5225 21 donor donor NN cord-010092-uftc8inx 5225 22 screening screening NN cord-010092-uftc8inx 5225 23 . . . cord-010092-uftc8inx 5226 1 Aims aim VBZ cord-010092-uftc8inx 5226 2 : : : cord-010092-uftc8inx 5226 3 To to TO cord-010092-uftc8inx 5226 4 determine determine VB cord-010092-uftc8inx 5226 5 the the DT cord-010092-uftc8inx 5226 6 percentages percentage NNS cord-010092-uftc8inx 5226 7 donors donor NNS cord-010092-uftc8inx 5226 8 answering answer VBG cord-010092-uftc8inx 5226 9 yes yes UH cord-010092-uftc8inx 5226 10 to to IN cord-010092-uftc8inx 5226 11 medication medication NN cord-010092-uftc8inx 5226 12 questions question NNS cord-010092-uftc8inx 5226 13 by by IN cord-010092-uftc8inx 5226 14 demographic demographic JJ cord-010092-uftc8inx 5226 15 variables variable NNS cord-010092-uftc8inx 5226 16 . . . cord-010092-uftc8inx 5227 1 Methods method NNS cord-010092-uftc8inx 5227 2 : : : cord-010092-uftc8inx 5228 1 All all DT cord-010092-uftc8inx 5228 2 whole whole JJ cord-010092-uftc8inx 5228 3 blood blood NN cord-010092-uftc8inx 5228 4 donors donor NNS cord-010092-uftc8inx 5228 5 who who WP cord-010092-uftc8inx 5228 6 completed complete VBD cord-010092-uftc8inx 5228 7 the the DT cord-010092-uftc8inx 5228 8 DHQ dhq NN cord-010092-uftc8inx 5228 9 ( ( -LRB- cord-010092-uftc8inx 5228 10 full full JJ cord-010092-uftc8inx 5228 11 length length NN cord-010092-uftc8inx 5228 12 or or CC cord-010092-uftc8inx 5228 13 abbreviated abbreviate VBN cord-010092-uftc8inx 5228 14 ) ) -RRB- cord-010092-uftc8inx 5228 15 in in IN cord-010092-uftc8inx 5228 16 2017 2017 CD cord-010092-uftc8inx 5228 17 were be VBD cord-010092-uftc8inx 5228 18 included include VBN cord-010092-uftc8inx 5228 19 in in IN cord-010092-uftc8inx 5228 20 the the DT cord-010092-uftc8inx 5228 21 analysis analysis NN cord-010092-uftc8inx 5228 22 . . . cord-010092-uftc8inx 5229 1 Donors donor NNS cord-010092-uftc8inx 5229 2 ' ' POS cord-010092-uftc8inx 5229 3 answers answer NNS cord-010092-uftc8inx 5229 4 to to IN cord-010092-uftc8inx 5229 5 each each DT cord-010092-uftc8inx 5229 6 of of IN cord-010092-uftc8inx 5229 7 the the DT cord-010092-uftc8inx 5229 8 6 6 CD cord-010092-uftc8inx 5229 9 medication medication NN cord-010092-uftc8inx 5229 10 questions question NNS cord-010092-uftc8inx 5229 11 were be VBD cord-010092-uftc8inx 5229 12 extracted extract VBN cord-010092-uftc8inx 5229 13 from from IN cord-010092-uftc8inx 5229 14 the the DT cord-010092-uftc8inx 5229 15 National National NNP cord-010092-uftc8inx 5229 16 Epidemiology Epidemiology NNP cord-010092-uftc8inx 5229 17 Donor Donor NNP cord-010092-uftc8inx 5229 18 Database Database NNP cord-010092-uftc8inx 5229 19 , , , cord-010092-uftc8inx 5229 20 as as RB cord-010092-uftc8inx 5229 21 well well RB cord-010092-uftc8inx 5229 22 as as IN cord-010092-uftc8inx 5229 23 sex sex NN cord-010092-uftc8inx 5229 24 and and CC cord-010092-uftc8inx 5229 25 age age NN cord-010092-uftc8inx 5229 26 . . . cord-010092-uftc8inx 5230 1 The the DT cord-010092-uftc8inx 5230 2 number number NN cord-010092-uftc8inx 5230 3 and and CC cord-010092-uftc8inx 5230 4 percentage percentage NN cord-010092-uftc8inx 5230 5 of of IN cord-010092-uftc8inx 5230 6 donation donation NN cord-010092-uftc8inx 5230 7 attempts attempt NNS cord-010092-uftc8inx 5230 8 in in IN cord-010092-uftc8inx 5230 9 which which WDT cord-010092-uftc8inx 5230 10 a a DT cord-010092-uftc8inx 5230 11 donor donor NN cord-010092-uftc8inx 5230 12 answered answer VBD cord-010092-uftc8inx 5230 13 yes yes UH cord-010092-uftc8inx 5230 14 to to IN cord-010092-uftc8inx 5230 15 each each DT cord-010092-uftc8inx 5230 16 medication medication NN cord-010092-uftc8inx 5230 17 question question NN cord-010092-uftc8inx 5230 18 were be VBD cord-010092-uftc8inx 5230 19 calculated calculate VBN cord-010092-uftc8inx 5230 20 . . . cord-010092-uftc8inx 5231 1 Donors donor NNS cord-010092-uftc8inx 5231 2 who who WP cord-010092-uftc8inx 5231 3 answered answer VBD cord-010092-uftc8inx 5231 4 yes yes UH cord-010092-uftc8inx 5231 5 to to IN cord-010092-uftc8inx 5231 6 any any DT cord-010092-uftc8inx 5231 7 medication medication NN cord-010092-uftc8inx 5231 8 question question NN cord-010092-uftc8inx 5231 9 were be VBD cord-010092-uftc8inx 5231 10 sorted sort VBN cord-010092-uftc8inx 5231 11 by by IN cord-010092-uftc8inx 5231 12 sex sex NN cord-010092-uftc8inx 5231 13 and and CC cord-010092-uftc8inx 5231 14 by by IN cord-010092-uftc8inx 5231 15 age age NN cord-010092-uftc8inx 5231 16 group group NN cord-010092-uftc8inx 5231 17 , , , cord-010092-uftc8inx 5231 18 the the DT cord-010092-uftc8inx 5231 19 totals total NNS cord-010092-uftc8inx 5231 20 and and CC cord-010092-uftc8inx 5231 21 percentages percentage NNS cord-010092-uftc8inx 5231 22 calculated calculate VBN cord-010092-uftc8inx 5231 23 . . . cord-010092-uftc8inx 5232 1 Results result NNS cord-010092-uftc8inx 5232 2 : : : cord-010092-uftc8inx 5233 1 There there EX cord-010092-uftc8inx 5233 2 were be VBD cord-010092-uftc8inx 5233 3 975,067 975,067 CD cord-010092-uftc8inx 5233 4 donation donation NN cord-010092-uftc8inx 5233 5 attempts attempt NNS cord-010092-uftc8inx 5233 6 with with IN cord-010092-uftc8inx 5233 7 a a DT cord-010092-uftc8inx 5233 8 completed complete VBN cord-010092-uftc8inx 5233 9 DHQ dhq NN cord-010092-uftc8inx 5233 10 . . . cord-010092-uftc8inx 5234 1 Overall overall RB cord-010092-uftc8inx 5234 2 , , , cord-010092-uftc8inx 5234 3 34 34 CD cord-010092-uftc8inx 5234 4 % % NN cord-010092-uftc8inx 5234 5 of of IN cord-010092-uftc8inx 5234 6 donors donor NNS cord-010092-uftc8inx 5234 7 answered answer VBD cord-010092-uftc8inx 5234 8 yes yes UH cord-010092-uftc8inx 5234 9 to to IN cord-010092-uftc8inx 5234 10 medications medication NNS cord-010092-uftc8inx 5234 11 in in IN cord-010092-uftc8inx 5234 12 the the DT cord-010092-uftc8inx 5234 13 last last JJ cord-010092-uftc8inx 5234 14 3 3 CD cord-010092-uftc8inx 5234 15 days day NNS cord-010092-uftc8inx 5234 16 , , , cord-010092-uftc8inx 5234 17 8 8 CD cord-010092-uftc8inx 5234 18 % % NN cord-010092-uftc8inx 5234 19 to to IN cord-010092-uftc8inx 5234 20 vaccination vaccination NN cord-010092-uftc8inx 5234 21 , , , cord-010092-uftc8inx 5234 22 and and CC cord-010092-uftc8inx 5234 23 less less JJR cord-010092-uftc8inx 5234 24 than than IN cord-010092-uftc8inx 5234 25 0.1 0.1 CD cord-010092-uftc8inx 5234 26 % % NN cord-010092-uftc8inx 5234 27 to to IN cord-010092-uftc8inx 5234 28 others other NNS cord-010092-uftc8inx 5234 29 ( ( -LRB- cord-010092-uftc8inx 5234 30 38 38 CD cord-010092-uftc8inx 5234 31 % % NN cord-010092-uftc8inx 5234 32 any any DT cord-010092-uftc8inx 5234 33 ) ) -RRB- cord-010092-uftc8inx 5234 34 . . . cord-010092-uftc8inx 5235 1 Slightly slightly RB cord-010092-uftc8inx 5235 2 more more JJR cord-010092-uftc8inx 5235 3 were be VBD cord-010092-uftc8inx 5235 4 female female JJ cord-010092-uftc8inx 5235 5 ( ( -LRB- cord-010092-uftc8inx 5235 6 42 42 CD cord-010092-uftc8inx 5235 7 vs vs IN cord-010092-uftc8inx 5235 8 36 36 CD cord-010092-uftc8inx 5235 9 % % NN cord-010092-uftc8inx 5235 10 ) ) -RRB- cord-010092-uftc8inx 5235 11 of of IN cord-010092-uftc8inx 5235 12 those those DT cord-010092-uftc8inx 5235 13 who who WP cord-010092-uftc8inx 5235 14 answered answer VBD cord-010092-uftc8inx 5235 15 yes yes UH cord-010092-uftc8inx 5235 16 to to IN cord-010092-uftc8inx 5235 17 any any DT cord-010092-uftc8inx 5235 18 medication medication NN cord-010092-uftc8inx 5235 19 question question NN cord-010092-uftc8inx 5235 20 , , , cord-010092-uftc8inx 5235 21 as as RB cord-010092-uftc8inx 5235 22 well well RB cord-010092-uftc8inx 5235 23 as as IN cord-010092-uftc8inx 5235 24 by by IN cord-010092-uftc8inx 5235 25 individual individual JJ cord-010092-uftc8inx 5235 26 question question NN cord-010092-uftc8inx 5235 27 . . . cord-010092-uftc8inx 5236 1 The the DT cord-010092-uftc8inx 5236 2 percentage percentage NN cord-010092-uftc8inx 5236 3 of of IN cord-010092-uftc8inx 5236 4 donors donor NNS cord-010092-uftc8inx 5236 5 answering answer VBG cord-010092-uftc8inx 5236 6 yes yes UH cord-010092-uftc8inx 5236 7 to to IN cord-010092-uftc8inx 5236 8 any any DT cord-010092-uftc8inx 5236 9 medication medication NN cord-010092-uftc8inx 5236 10 question question NN cord-010092-uftc8inx 5236 11 increased increase VBD cord-010092-uftc8inx 5236 12 progressively progressively RB cord-010092-uftc8inx 5236 13 in in IN cord-010092-uftc8inx 5236 14 each each DT cord-010092-uftc8inx 5236 15 age age NN cord-010092-uftc8inx 5236 16 group group NN cord-010092-uftc8inx 5236 17 from from IN cord-010092-uftc8inx 5236 18 24 24 CD cord-010092-uftc8inx 5236 19 % % NN cord-010092-uftc8inx 5236 20 of of IN cord-010092-uftc8inx 5236 21 17 17 CD cord-010092-uftc8inx 5236 22 - - SYM cord-010092-uftc8inx 5236 23 19 19 CD cord-010092-uftc8inx 5236 24 year year NN cord-010092-uftc8inx 5236 25 olds old NNS cord-010092-uftc8inx 5236 26 to to IN cord-010092-uftc8inx 5236 27 57 57 CD cord-010092-uftc8inx 5236 28 % % NN cord-010092-uftc8inx 5236 29 aged age VBN cord-010092-uftc8inx 5237 1 60 60 CD cord-010092-uftc8inx 5237 2 + + CC cord-010092-uftc8inx 5238 1 ( ( -LRB- cord-010092-uftc8inx 5238 2 P p NN cord-010092-uftc8inx 5238 3 < < XX cord-010092-uftc8inx 5238 4 0.0001 0.0001 CD cord-010092-uftc8inx 5238 5 for for IN cord-010092-uftc8inx 5238 6 trend trend NN cord-010092-uftc8inx 5238 7 ) ) -RRB- cord-010092-uftc8inx 5238 8 . . . cord-010092-uftc8inx 5239 1 Summary Summary NNP cord-010092-uftc8inx 5239 2 / / SYM cord-010092-uftc8inx 5239 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 5239 4 : : : cord-010092-uftc8inx 5240 1 More More JJR cord-010092-uftc8inx 5240 2 than than IN cord-010092-uftc8inx 5240 3 one one CD cord-010092-uftc8inx 5240 4 third third NN cord-010092-uftc8inx 5240 5 of of IN cord-010092-uftc8inx 5240 6 all all DT cord-010092-uftc8inx 5240 7 donation donation NN cord-010092-uftc8inx 5240 8 attempts attempt NNS cord-010092-uftc8inx 5240 9 answer answer VBP cord-010092-uftc8inx 5240 10 yes yes UH cord-010092-uftc8inx 5240 11 to to IN cord-010092-uftc8inx 5240 12 a a DT cord-010092-uftc8inx 5240 13 medication medication NN cord-010092-uftc8inx 5240 14 question question NN cord-010092-uftc8inx 5240 15 and and CC cord-010092-uftc8inx 5240 16 require require VB cord-010092-uftc8inx 5240 17 further further JJ cord-010092-uftc8inx 5240 18 questioning questioning NN cord-010092-uftc8inx 5240 19 and and CC cord-010092-uftc8inx 5240 20 documentation documentation NN cord-010092-uftc8inx 5240 21 . . . cord-010092-uftc8inx 5241 1 This this DT cord-010092-uftc8inx 5241 2 is be VBZ cord-010092-uftc8inx 5241 3 more more RBR cord-010092-uftc8inx 5241 4 common common JJ cord-010092-uftc8inx 5241 5 in in IN cord-010092-uftc8inx 5241 6 older old JJR cord-010092-uftc8inx 5241 7 donors donor NNS cord-010092-uftc8inx 5241 8 and and CC cord-010092-uftc8inx 5241 9 follows follow VBZ cord-010092-uftc8inx 5241 10 a a DT cord-010092-uftc8inx 5241 11 similar similar JJ cord-010092-uftc8inx 5241 12 trend trend NN cord-010092-uftc8inx 5241 13 to to IN cord-010092-uftc8inx 5241 14 general general JJ cord-010092-uftc8inx 5241 15 population population NN cord-010092-uftc8inx 5241 16 medication medication NN cord-010092-uftc8inx 5241 17 use use NN cord-010092-uftc8inx 5241 18 . . . cord-010092-uftc8inx 5242 1 Comparison comparison NN cord-010092-uftc8inx 5242 2 of of IN cord-010092-uftc8inx 5242 3 ways way NNS cord-010092-uftc8inx 5242 4 of of IN cord-010092-uftc8inx 5242 5 assessing assess VBG cord-010092-uftc8inx 5242 6 medication medication NN cord-010092-uftc8inx 5242 7 use use NN cord-010092-uftc8inx 5242 8 in in IN cord-010092-uftc8inx 5242 9 different different JJ cord-010092-uftc8inx 5242 10 countries country NNS cord-010092-uftc8inx 5242 11 may may MD cord-010092-uftc8inx 5242 12 help help VB cord-010092-uftc8inx 5242 13 identify identify VB cord-010092-uftc8inx 5242 14 effective effective JJ cord-010092-uftc8inx 5242 15 but but CC cord-010092-uftc8inx 5242 16 more more RBR cord-010092-uftc8inx 5242 17 efficient efficient JJ cord-010092-uftc8inx 5242 18 approaches approach NNS cord-010092-uftc8inx 5242 19 . . . cord-010092-uftc8inx 5243 1 In in IN cord-010092-uftc8inx 5243 2 addition addition NN cord-010092-uftc8inx 5243 3 , , , cord-010092-uftc8inx 5243 4 the the DT cord-010092-uftc8inx 5243 5 contribution contribution NN cord-010092-uftc8inx 5243 6 to to IN cord-010092-uftc8inx 5243 7 donor donor NN cord-010092-uftc8inx 5243 8 and and CC cord-010092-uftc8inx 5243 9 recipient recipient NN cord-010092-uftc8inx 5243 10 safety safety NN cord-010092-uftc8inx 5243 11 of of IN cord-010092-uftc8inx 5243 12 assessing assess VBG cord-010092-uftc8inx 5243 13 all all DT cord-010092-uftc8inx 5243 14 medications medication NNS cord-010092-uftc8inx 5243 15 should should MD cord-010092-uftc8inx 5243 16 be be VB cord-010092-uftc8inx 5243 17 assessed assess VBN cord-010092-uftc8inx 5243 18 . . . cord-010092-uftc8inx 5244 1 BLOOD blood NN cord-010092-uftc8inx 5244 2 CENTER center NN cord-010092-uftc8inx 5244 3 EXPERIENCE experience NN cord-010092-uftc8inx 5244 4 WITH with IN cord-010092-uftc8inx 5244 5 TRIMA TRIMA NNP cord-010092-uftc8inx 5244 6 ACCEL ACCEL NNP cord-010092-uftc8inx 5244 7 7 7 CD cord-010092-uftc8inx 5244 8 AND and CC cord-010092-uftc8inx 5245 1 TOMES TOMES NNP cord-010092-uftc8inx 5245 2 SOFTWARE software NN cord-010092-uftc8inx 5245 3 J J NNP cord-010092-uftc8inx 5245 4 Schreier Schreier NNP cord-010092-uftc8inx 5245 5 1 1 CD cord-010092-uftc8inx 5245 6 , , , cord-010092-uftc8inx 5245 7 A A NNP cord-010092-uftc8inx 5245 8 Davison Davison NNP cord-010092-uftc8inx 5245 9 1 1 CD cord-010092-uftc8inx 5245 10 , , , cord-010092-uftc8inx 5245 11 J J NNP cord-010092-uftc8inx 5245 12 Gambarte Gambarte NNP cord-010092-uftc8inx 5245 13 2 2 CD cord-010092-uftc8inx 5245 14 , , , cord-010092-uftc8inx 5245 15 Y Y NNP cord-010092-uftc8inx 5245 16 L L NNP cord-010092-uftc8inx 5245 17 opez opez NNP cord-010092-uftc8inx 5245 18 2 2 CD cord-010092-uftc8inx 5245 19 , , , cord-010092-uftc8inx 5245 20 C C NNP cord-010092-uftc8inx 5245 21 Calonge Calonge NNP cord-010092-uftc8inx 5245 22 2 2 CD cord-010092-uftc8inx 5245 23 and and CC cord-010092-uftc8inx 5245 24 E E NNP cord-010092-uftc8inx 5245 25 Herranz Herranz NNP cord-010092-uftc8inx 5246 1 2 2 LS cord-010092-uftc8inx 5246 2 1 1 CD cord-010092-uftc8inx 5246 3 Terumo Terumo NNP cord-010092-uftc8inx 5246 4 BCT BCT NNP cord-010092-uftc8inx 5246 5 , , , cord-010092-uftc8inx 5246 6 Lakewood Lakewood NNP cord-010092-uftc8inx 5246 7 , , , cord-010092-uftc8inx 5246 8 United United NNP cord-010092-uftc8inx 5246 9 States States NNP cord-010092-uftc8inx 5246 10 2 2 CD cord-010092-uftc8inx 5246 11 Centro Centro NNP cord-010092-uftc8inx 5246 12 de de NNP cord-010092-uftc8inx 5246 13 Transfusi Transfusi NNP cord-010092-uftc8inx 5246 14 on on IN cord-010092-uftc8inx 5246 15 de de NNP cord-010092-uftc8inx 5246 16 la la FW cord-010092-uftc8inx 5246 17 Comunidad Comunidad NNP cord-010092-uftc8inx 5246 18 de de NNP cord-010092-uftc8inx 5246 19 Madrid Madrid NNP cord-010092-uftc8inx 5246 20 , , , cord-010092-uftc8inx 5246 21 Madrid Madrid NNP cord-010092-uftc8inx 5247 1 , , , cord-010092-uftc8inx 5247 2 Spain Spain NNP cord-010092-uftc8inx 5247 3 Background Background NNP cord-010092-uftc8inx 5247 4 : : : cord-010092-uftc8inx 5248 1 In in IN cord-010092-uftc8inx 5248 2 the the DT cord-010092-uftc8inx 5248 3 Madrid Madrid NNP cord-010092-uftc8inx 5248 4 community community NN cord-010092-uftc8inx 5248 5 , , , cord-010092-uftc8inx 5248 6 more more JJR cord-010092-uftc8inx 5248 7 than than IN cord-010092-uftc8inx 5248 8 4000 4000 CD cord-010092-uftc8inx 5248 9 apheresis apheresis NN cord-010092-uftc8inx 5248 10 platelet platelet NN cord-010092-uftc8inx 5248 11 collections collection NNS cord-010092-uftc8inx 5248 12 were be VBD cord-010092-uftc8inx 5248 13 completed complete VBN cord-010092-uftc8inx 5248 14 in in IN cord-010092-uftc8inx 5248 15 2018 2018 CD cord-010092-uftc8inx 5248 16 , , , cord-010092-uftc8inx 5248 17 of of IN cord-010092-uftc8inx 5248 18 which which WDT cord-010092-uftc8inx 5248 19 almost almost RB cord-010092-uftc8inx 5248 20 3000 3000 CD cord-010092-uftc8inx 5248 21 were be VBD cord-010092-uftc8inx 5248 22 completed complete VBN cord-010092-uftc8inx 5248 23 in in IN cord-010092-uftc8inx 5248 24 the the DT cord-010092-uftc8inx 5248 25 blood blood NN cord-010092-uftc8inx 5248 26 transfusion transfusion NN cord-010092-uftc8inx 5248 27 center center NN cord-010092-uftc8inx 5248 28 and and CC cord-010092-uftc8inx 5248 29 the the DT cord-010092-uftc8inx 5248 30 remainder remainder NN cord-010092-uftc8inx 5248 31 in in IN cord-010092-uftc8inx 5248 32 several several JJ cord-010092-uftc8inx 5248 33 hospitals hospital NNS cord-010092-uftc8inx 5248 34 in in IN cord-010092-uftc8inx 5248 35 the the DT cord-010092-uftc8inx 5248 36 region region NN cord-010092-uftc8inx 5248 37 . . . cord-010092-uftc8inx 5249 1 Trima Trima NNP cord-010092-uftc8inx 5249 2 Accel Accel NNP cord-010092-uftc8inx 5249 3 7 7 CD cord-010092-uftc8inx 5249 4 was be VBD cord-010092-uftc8inx 5249 5 implemented implement VBN cord-010092-uftc8inx 5249 6 to to TO cord-010092-uftc8inx 5249 7 meet meet VB cord-010092-uftc8inx 5249 8 the the DT cord-010092-uftc8inx 5249 9 productivity productivity NN cord-010092-uftc8inx 5249 10 needs need NNS cord-010092-uftc8inx 5249 11 of of IN cord-010092-uftc8inx 5249 12 the the DT cord-010092-uftc8inx 5249 13 blood blood NN cord-010092-uftc8inx 5249 14 transfusion transfusion NN cord-010092-uftc8inx 5249 15 center center NN cord-010092-uftc8inx 5249 16 while while IN cord-010092-uftc8inx 5249 17 improving improve VBG cord-010092-uftc8inx 5249 18 the the DT cord-010092-uftc8inx 5249 19 donation donation NN cord-010092-uftc8inx 5249 20 experience experience NN cord-010092-uftc8inx 5249 21 . . . cord-010092-uftc8inx 5250 1 TOMEs TOMEs NNPS cord-010092-uftc8inx 5250 2 ( ( -LRB- cord-010092-uftc8inx 5250 3 Terumo Terumo NNP cord-010092-uftc8inx 5250 4 Operational Operational NNP cord-010092-uftc8inx 5250 5 Medical Medical NNP cord-010092-uftc8inx 5250 6 Equipment Equipment NNP cord-010092-uftc8inx 5250 7 Software Software NNP cord-010092-uftc8inx 5250 8 ) ) -RRB- cord-010092-uftc8inx 5250 9 , , , cord-010092-uftc8inx 5250 10 which which WDT cord-010092-uftc8inx 5250 11 enables enable VBZ cord-010092-uftc8inx 5250 12 bidirectional bidirectional JJ cord-010092-uftc8inx 5250 13 communication communication NN cord-010092-uftc8inx 5250 14 with with IN cord-010092-uftc8inx 5250 15 Trima Trima NNP cord-010092-uftc8inx 5250 16 Accel Accel NNP cord-010092-uftc8inx 5250 17 devices device NNS cord-010092-uftc8inx 5250 18 , , , cord-010092-uftc8inx 5250 19 was be VBD cord-010092-uftc8inx 5250 20 used use VBN cord-010092-uftc8inx 5250 21 to to TO cord-010092-uftc8inx 5250 22 connect connect VB cord-010092-uftc8inx 5250 23 and and CC cord-010092-uftc8inx 5250 24 centrally centrally RB cord-010092-uftc8inx 5250 25 manage manage VB cord-010092-uftc8inx 5250 26 all all DT cord-010092-uftc8inx 5250 27 Trima Trima NNP cord-010092-uftc8inx 5250 28 Accel Accel NNP cord-010092-uftc8inx 5250 29 7 7 CD cord-010092-uftc8inx 5250 30 devices device NNS cord-010092-uftc8inx 5250 31 with with IN cord-010092-uftc8inx 5250 32 automated automate VBN cord-010092-uftc8inx 5250 33 data data NN cord-010092-uftc8inx 5250 34 capture capture NN cord-010092-uftc8inx 5250 35 and and CC cord-010092-uftc8inx 5250 36 reporting reporting NN cord-010092-uftc8inx 5250 37 . . . cord-010092-uftc8inx 5251 1 Aims aim VBZ cord-010092-uftc8inx 5251 2 : : : cord-010092-uftc8inx 5252 1 The the DT cord-010092-uftc8inx 5252 2 aim aim NN cord-010092-uftc8inx 5252 3 of of IN cord-010092-uftc8inx 5252 4 this this DT cord-010092-uftc8inx 5252 5 study study NN cord-010092-uftc8inx 5252 6 was be VBD cord-010092-uftc8inx 5252 7 to to TO cord-010092-uftc8inx 5252 8 evaluate evaluate VB cord-010092-uftc8inx 5252 9 operational operational JJ cord-010092-uftc8inx 5252 10 improvements improvement NNS cord-010092-uftc8inx 5252 11 using use VBG cord-010092-uftc8inx 5252 12 Trima Trima NNP cord-010092-uftc8inx 5252 13 Accel Accel NNP cord-010092-uftc8inx 5252 14 7 7 CD cord-010092-uftc8inx 5252 15 with with IN cord-010092-uftc8inx 5252 16 TOMEs TOMEs NNPS cord-010092-uftc8inx 5252 17 compared compare VBN cord-010092-uftc8inx 5252 18 to to IN cord-010092-uftc8inx 5252 19 Trima Trima NNP cord-010092-uftc8inx 5252 20 Accel Accel NNP cord-010092-uftc8inx 5252 21 Version Version NNP cord-010092-uftc8inx 5252 22 6 6 CD cord-010092-uftc8inx 5252 23 . . . cord-010092-uftc8inx 5253 1 Methods method NNS cord-010092-uftc8inx 5253 2 : : : cord-010092-uftc8inx 5253 3 This this DT cord-010092-uftc8inx 5253 4 was be VBD cord-010092-uftc8inx 5253 5 a a DT cord-010092-uftc8inx 5253 6 retrospective retrospective JJ cord-010092-uftc8inx 5253 7 study study NN cord-010092-uftc8inx 5253 8 analyzing analyze VBG cord-010092-uftc8inx 5253 9 1372 1372 CD cord-010092-uftc8inx 5253 10 apheresis apheresis NN cord-010092-uftc8inx 5253 11 procedures procedure NNS cord-010092-uftc8inx 5253 12 on on IN cord-010092-uftc8inx 5253 13 Trima Trima NNP cord-010092-uftc8inx 5253 14 Accel Accel NNP cord-010092-uftc8inx 5253 15 Version Version NNP cord-010092-uftc8inx 5253 16 6 6 CD cord-010092-uftc8inx 5253 17 during during IN cord-010092-uftc8inx 5253 18 the the DT cord-010092-uftc8inx 5253 19 control control NN cord-010092-uftc8inx 5253 20 period period NN cord-010092-uftc8inx 5253 21 from from IN cord-010092-uftc8inx 5253 22 2 2 CD cord-010092-uftc8inx 5253 23 January January NNP cord-010092-uftc8inx 5253 24 2018 2018 CD cord-010092-uftc8inx 5253 25 to to IN cord-010092-uftc8inx 5253 26 10 10 CD cord-010092-uftc8inx 5253 27 September September NNP cord-010092-uftc8inx 5253 28 2018 2018 CD cord-010092-uftc8inx 5253 29 compared compare VBN cord-010092-uftc8inx 5253 30 to to IN cord-010092-uftc8inx 5253 31 541 541 CD cord-010092-uftc8inx 5253 32 apheresis apheresis NN cord-010092-uftc8inx 5253 33 procedures procedure NNS cord-010092-uftc8inx 5253 34 on on IN cord-010092-uftc8inx 5253 35 Trima Trima NNP cord-010092-uftc8inx 5253 36 Accel Accel NNP cord-010092-uftc8inx 5253 37 7 7 CD cord-010092-uftc8inx 5253 38 during during IN cord-010092-uftc8inx 5253 39 the the DT cord-010092-uftc8inx 5253 40 test test NN cord-010092-uftc8inx 5253 41 period period NN cord-010092-uftc8inx 5253 42 from from IN cord-010092-uftc8inx 5253 43 11 11 CD cord-010092-uftc8inx 5253 44 September September NNP cord-010092-uftc8inx 5253 45 2018 2018 CD cord-010092-uftc8inx 5253 46 to to IN cord-010092-uftc8inx 5253 47 28 28 CD cord-010092-uftc8inx 5253 48 December December NNP cord-010092-uftc8inx 5253 49 2018 2018 CD cord-010092-uftc8inx 5253 50 . . . cord-010092-uftc8inx 5254 1 This this DT cord-010092-uftc8inx 5254 2 was be VBD cord-010092-uftc8inx 5254 3 not not RB cord-010092-uftc8inx 5254 4 a a DT cord-010092-uftc8inx 5254 5 paired paired JJ cord-010092-uftc8inx 5254 6 study study NN cord-010092-uftc8inx 5254 7 . . . cord-010092-uftc8inx 5255 1 Operator operator NN cord-010092-uftc8inx 5255 2 interventions intervention NNS cord-010092-uftc8inx 5255 3 , , , cord-010092-uftc8inx 5255 4 and and CC cord-010092-uftc8inx 5255 5 completed complete VBN cord-010092-uftc8inx 5255 6 procedure procedure NN cord-010092-uftc8inx 5255 7 rate rate NN cord-010092-uftc8inx 5255 8 comparisons comparison NNS cord-010092-uftc8inx 5255 9 , , , cord-010092-uftc8inx 5255 10 were be VBD cord-010092-uftc8inx 5255 11 analyzed analyze VBN cord-010092-uftc8inx 5255 12 using use VBG cord-010092-uftc8inx 5255 13 a a DT cord-010092-uftc8inx 5255 14 2-proportions 2-proportions CD cord-010092-uftc8inx 5255 15 test test NN cord-010092-uftc8inx 5255 16 , , , cord-010092-uftc8inx 5255 17 whereas whereas IN cord-010092-uftc8inx 5255 18 donor donor NN cord-010092-uftc8inx 5255 19 demographic demographic JJ cord-010092-uftc8inx 5255 20 data datum NNS cord-010092-uftc8inx 5255 21 were be VBD cord-010092-uftc8inx 5255 22 analyzed analyze VBN cord-010092-uftc8inx 5255 23 using use VBG cord-010092-uftc8inx 5255 24 a a DT cord-010092-uftc8inx 5255 25 2-sample 2-sample CD cord-010092-uftc8inx 5255 26 t t NN cord-010092-uftc8inx 5255 27 - - HYPH cord-010092-uftc8inx 5255 28 test test NN cord-010092-uftc8inx 5255 29 . . . cord-010092-uftc8inx 5256 1 Results result NNS cord-010092-uftc8inx 5256 2 : : : cord-010092-uftc8inx 5257 1 Trima Trima NNP cord-010092-uftc8inx 5257 2 Accel Accel NNP cord-010092-uftc8inx 5257 3 was be VBD cord-010092-uftc8inx 5257 4 used use VBN cord-010092-uftc8inx 5257 5 to to TO cord-010092-uftc8inx 5257 6 collect collect VB cord-010092-uftc8inx 5257 7 single single JJ cord-010092-uftc8inx 5257 8 and and CC cord-010092-uftc8inx 5257 9 double double JJ cord-010092-uftc8inx 5257 10 platelet platelet NN cord-010092-uftc8inx 5257 11 products product NNS cord-010092-uftc8inx 5257 12 stored store VBN cord-010092-uftc8inx 5257 13 in in IN cord-010092-uftc8inx 5257 14 platelet platelet NN cord-010092-uftc8inx 5257 15 additive additive NN cord-010092-uftc8inx 5257 16 solution solution NN cord-010092-uftc8inx 5257 17 . . . cord-010092-uftc8inx 5258 1 Operators operator NNS cord-010092-uftc8inx 5258 2 selected select VBD cord-010092-uftc8inx 5258 3 either either CC cord-010092-uftc8inx 5258 4 a a DT cord-010092-uftc8inx 5258 5 single single JJ cord-010092-uftc8inx 5258 6 ( ( -LRB- cord-010092-uftc8inx 5258 7 target target NN cord-010092-uftc8inx 5258 8 platelet platelet NN cord-010092-uftc8inx 5258 9 yield yield NN cord-010092-uftc8inx 5258 10 = = SYM cord-010092-uftc8inx 5258 11 3.0 3.0 CD cord-010092-uftc8inx 5258 12 or or CC cord-010092-uftc8inx 5258 13 3.5 3.5 CD cord-010092-uftc8inx 5258 14 9 9 CD cord-010092-uftc8inx 5258 15 10 10 CD cord-010092-uftc8inx 5258 16 11 11 CD cord-010092-uftc8inx 5258 17 ) ) -RRB- cord-010092-uftc8inx 5258 18 or or CC cord-010092-uftc8inx 5258 19 double double JJ cord-010092-uftc8inx 5258 20 ( ( -LRB- cord-010092-uftc8inx 5258 21 target target NN cord-010092-uftc8inx 5258 22 platelet platelet NN cord-010092-uftc8inx 5258 23 yield yield NN cord-010092-uftc8inx 5258 24 = = SYM cord-010092-uftc8inx 5258 25 6.0 6.0 CD cord-010092-uftc8inx 5258 26 9 9 CD cord-010092-uftc8inx 5258 27 10 10 CD cord-010092-uftc8inx 5258 28 11 11 CD cord-010092-uftc8inx 5258 29 ) ) -RRB- cord-010092-uftc8inx 5258 30 platelet platelet NN cord-010092-uftc8inx 5258 31 donation donation NN cord-010092-uftc8inx 5258 32 based base VBN cord-010092-uftc8inx 5258 33 on on IN cord-010092-uftc8inx 5258 34 desired desire VBN cord-010092-uftc8inx 5258 35 procedure procedure NN cord-010092-uftc8inx 5258 36 time time NN cord-010092-uftc8inx 5258 37 not not RB cord-010092-uftc8inx 5258 38 the the DT cord-010092-uftc8inx 5258 39 maximum maximum JJ cord-010092-uftc8inx 5258 40 number number NN cord-010092-uftc8inx 5258 41 of of IN cord-010092-uftc8inx 5258 42 products product NNS cord-010092-uftc8inx 5258 43 that that WDT cord-010092-uftc8inx 5258 44 could could MD cord-010092-uftc8inx 5258 45 have have VB cord-010092-uftc8inx 5258 46 been be VBN cord-010092-uftc8inx 5258 47 collected collect VBN cord-010092-uftc8inx 5258 48 per per IN cord-010092-uftc8inx 5258 49 donor donor NN cord-010092-uftc8inx 5258 50 . . . cord-010092-uftc8inx 5259 1 No no DT cord-010092-uftc8inx 5259 2 statistically statistically RB cord-010092-uftc8inx 5259 3 significant significant JJ cord-010092-uftc8inx 5259 4 differences difference NNS cord-010092-uftc8inx 5259 5 were be VBD cord-010092-uftc8inx 5259 6 observed observe VBN cord-010092-uftc8inx 5259 7 for for IN cord-010092-uftc8inx 5259 8 donors donor NNS cord-010092-uftc8inx 5259 9 in in IN cord-010092-uftc8inx 5259 10 the the DT cord-010092-uftc8inx 5259 11 test test NN cord-010092-uftc8inx 5259 12 arm arm NN cord-010092-uftc8inx 5259 13 compared compare VBN cord-010092-uftc8inx 5259 14 to to IN cord-010092-uftc8inx 5259 15 donors donor NNS cord-010092-uftc8inx 5259 16 in in IN cord-010092-uftc8inx 5259 17 the the DT cord-010092-uftc8inx 5259 18 control control NN cord-010092-uftc8inx 5259 19 arm arm NN cord-010092-uftc8inx 5259 20 for for IN cord-010092-uftc8inx 5259 21 total total JJ cord-010092-uftc8inx 5259 22 blood blood NN cord-010092-uftc8inx 5259 23 volume volume NN cord-010092-uftc8inx 5259 24 ( ( -LRB- cord-010092-uftc8inx 5259 25 control control NN cord-010092-uftc8inx 5259 26 = = SYM cord-010092-uftc8inx 5259 27 5148 5148 CD cord-010092-uftc8inx 5259 28 mL ml NN cord-010092-uftc8inx 5259 29 , , , cord-010092-uftc8inx 5259 30 test test NN cord-010092-uftc8inx 5259 31 = = NFP cord-010092-uftc8inx 5260 1 5124 5124 CD cord-010092-uftc8inx 5260 2 mL ml NN cord-010092-uftc8inx 5260 3 , , , cord-010092-uftc8inx 5260 4 P p NN cord-010092-uftc8inx 5260 5 = = SYM cord-010092-uftc8inx 5260 6 0.545 0.545 CD cord-010092-uftc8inx 5260 7 ) ) -RRB- cord-010092-uftc8inx 5260 8 , , , cord-010092-uftc8inx 5260 9 hematocrit hematocrit NN cord-010092-uftc8inx 5260 10 ( ( -LRB- cord-010092-uftc8inx 5260 11 control control NN cord-010092-uftc8inx 5260 12 = = SYM cord-010092-uftc8inx 5260 13 43.7 43.7 CD cord-010092-uftc8inx 5260 14 % % NN cord-010092-uftc8inx 5260 15 , , , cord-010092-uftc8inx 5260 16 test test NN cord-010092-uftc8inx 5260 17 = = SYM cord-010092-uftc8inx 5260 18 43.6 43.6 CD cord-010092-uftc8inx 5260 19 % % NN cord-010092-uftc8inx 5260 20 , , , cord-010092-uftc8inx 5260 21 P p NN cord-010092-uftc8inx 5260 22 = = SYM cord-010092-uftc8inx 5260 23 0.233 0.233 CD cord-010092-uftc8inx 5260 24 ) ) -RRB- cord-010092-uftc8inx 5260 25 , , , cord-010092-uftc8inx 5260 26 or or CC cord-010092-uftc8inx 5260 27 platelet platelet NN cord-010092-uftc8inx 5260 28 pre pre JJ cord-010092-uftc8inx 5260 29 - - NN cord-010092-uftc8inx 5260 30 count count VB cord-010092-uftc8inx 5260 31 ( ( -LRB- cord-010092-uftc8inx 5260 32 control control NN cord-010092-uftc8inx 5260 33 = = SYM cord-010092-uftc8inx 5260 34 249 249 CD cord-010092-uftc8inx 5260 35 9 9 CD cord-010092-uftc8inx 5260 36 10 10 CD cord-010092-uftc8inx 5260 37 3 3 CD cord-010092-uftc8inx 5261 1 / / SYM cord-010092-uftc8inx 5261 2 lL lL NNP cord-010092-uftc8inx 5261 3 , , , cord-010092-uftc8inx 5261 4 test test NN cord-010092-uftc8inx 5261 5 = = SYM cord-010092-uftc8inx 5261 6 253 253 CD cord-010092-uftc8inx 5261 7 9 9 CD cord-010092-uftc8inx 5261 8 10 10 CD cord-010092-uftc8inx 5261 9 3 3 CD cord-010092-uftc8inx 5262 1 /lL /lL NFP cord-010092-uftc8inx 5262 2 , , , cord-010092-uftc8inx 5262 3 P p NN cord-010092-uftc8inx 5262 4 = = SYM cord-010092-uftc8inx 5262 5 0.091 0.091 CD cord-010092-uftc8inx 5262 6 ) ) -RRB- cord-010092-uftc8inx 5262 7 . . . cord-010092-uftc8inx 5263 1 Females female NNS cord-010092-uftc8inx 5263 2 represented represent VBD cord-010092-uftc8inx 5263 3 21 21 CD cord-010092-uftc8inx 5263 4 % % NN cord-010092-uftc8inx 5263 5 of of IN cord-010092-uftc8inx 5263 6 donors donor NNS cord-010092-uftc8inx 5263 7 in in IN cord-010092-uftc8inx 5263 8 the the DT cord-010092-uftc8inx 5263 9 Control Control NNP cord-010092-uftc8inx 5263 10 arm arm NN cord-010092-uftc8inx 5263 11 compared compare VBN cord-010092-uftc8inx 5263 12 to to IN cord-010092-uftc8inx 5263 13 23 23 CD cord-010092-uftc8inx 5263 14 % % NN cord-010092-uftc8inx 5263 15 of of IN cord-010092-uftc8inx 5263 16 donors donor NNS cord-010092-uftc8inx 5263 17 in in IN cord-010092-uftc8inx 5263 18 the the DT cord-010092-uftc8inx 5263 19 Test test NN cord-010092-uftc8inx 5263 20 arm arm NN cord-010092-uftc8inx 5263 21 . . . cord-010092-uftc8inx 5264 1 Platelet platelet NN cord-010092-uftc8inx 5264 2 split split NN cord-010092-uftc8inx 5264 3 rate rate NN cord-010092-uftc8inx 5264 4 ( ( -LRB- cord-010092-uftc8inx 5264 5 platelet platelet NN cord-010092-uftc8inx 5264 6 products product NNS cord-010092-uftc8inx 5264 7 per per IN cord-010092-uftc8inx 5264 8 procedure procedure NN cord-010092-uftc8inx 5264 9 ) ) -RRB- cord-010092-uftc8inx 5264 10 increased increase VBD cord-010092-uftc8inx 5264 11 from from IN cord-010092-uftc8inx 5264 12 1.15 1.15 CD cord-010092-uftc8inx 5264 13 with with IN cord-010092-uftc8inx 5264 14 Trima Trima NNP cord-010092-uftc8inx 5264 15 Accel Accel NNP cord-010092-uftc8inx 5264 16 Version Version NNP cord-010092-uftc8inx 5264 17 6 6 CD cord-010092-uftc8inx 5264 18 to to IN cord-010092-uftc8inx 5264 19 1.18 1.18 CD cord-010092-uftc8inx 5264 20 with with IN cord-010092-uftc8inx 5264 21 Trima Trima NNP cord-010092-uftc8inx 5264 22 Accel Accel NNP cord-010092-uftc8inx 5264 23 7 7 CD cord-010092-uftc8inx 5264 24 ; ; , cord-010092-uftc8inx 5264 25 procedure procedure NN cord-010092-uftc8inx 5264 26 time time NN cord-010092-uftc8inx 5264 27 decreased decrease VBD cord-010092-uftc8inx 5264 28 from from IN cord-010092-uftc8inx 5264 29 55.7 55.7 CD cord-010092-uftc8inx 5264 30 min min NN cord-010092-uftc8inx 5264 31 to to IN cord-010092-uftc8inx 5264 32 53.3 53.3 CD cord-010092-uftc8inx 5264 33 min min NN cord-010092-uftc8inx 5264 34 for for IN cord-010092-uftc8inx 5264 35 single single JJ cord-010092-uftc8inx 5264 36 collections collection NNS cord-010092-uftc8inx 5264 37 and and CC cord-010092-uftc8inx 5264 38 from from IN cord-010092-uftc8inx 5264 39 63.0 63.0 CD cord-010092-uftc8inx 5264 40 min min NN cord-010092-uftc8inx 5264 41 to to IN cord-010092-uftc8inx 5264 42 60.9 60.9 CD cord-010092-uftc8inx 5264 43 min min NN cord-010092-uftc8inx 5264 44 for for IN cord-010092-uftc8inx 5264 45 double double JJ cord-010092-uftc8inx 5264 46 collections collection NNS cord-010092-uftc8inx 5264 47 with with IN cord-010092-uftc8inx 5264 48 Trima Trima NNP cord-010092-uftc8inx 5264 49 Accel Accel NNP cord-010092-uftc8inx 5264 50 7 7 CD cord-010092-uftc8inx 5264 51 ( ( -LRB- cord-010092-uftc8inx 5264 52 these these DT cord-010092-uftc8inx 5264 53 differences difference NNS cord-010092-uftc8inx 5264 54 were be VBD cord-010092-uftc8inx 5264 55 not not RB cord-010092-uftc8inx 5264 56 statistically statistically RB cord-010092-uftc8inx 5264 57 significant significant JJ cord-010092-uftc8inx 5264 58 ) ) -RRB- cord-010092-uftc8inx 5264 59 . . . cord-010092-uftc8inx 5265 1 The the DT cord-010092-uftc8inx 5265 2 percentage percentage NN cord-010092-uftc8inx 5265 3 of of IN cord-010092-uftc8inx 5265 4 procedures procedure NNS cord-010092-uftc8inx 5265 5 that that WDT cord-010092-uftc8inx 5265 6 completed complete VBD cord-010092-uftc8inx 5265 7 with with IN cord-010092-uftc8inx 5265 8 no no DT cord-010092-uftc8inx 5265 9 operator operator NN cord-010092-uftc8inx 5265 10 interventions intervention NNS cord-010092-uftc8inx 5265 11 due due JJ cord-010092-uftc8inx 5265 12 to to IN cord-010092-uftc8inx 5265 13 access access NN cord-010092-uftc8inx 5265 14 alerts alert NNS cord-010092-uftc8inx 5265 15 increased increase VBD cord-010092-uftc8inx 5265 16 from from IN cord-010092-uftc8inx 5265 17 62.4 62.4 CD cord-010092-uftc8inx 5265 18 % % NN cord-010092-uftc8inx 5265 19 to to IN cord-010092-uftc8inx 5265 20 84.8 84.8 CD cord-010092-uftc8inx 5265 21 % % NN cord-010092-uftc8inx 5265 22 ( ( -LRB- cord-010092-uftc8inx 5265 23 P p NN cord-010092-uftc8inx 5265 24 < < XX cord-010092-uftc8inx 5265 25 0.001 0.001 CD cord-010092-uftc8inx 5265 26 ) ) -RRB- cord-010092-uftc8inx 5265 27 and and CC cord-010092-uftc8inx 5265 28 the the DT cord-010092-uftc8inx 5265 29 rate rate NN cord-010092-uftc8inx 5265 30 of of IN cord-010092-uftc8inx 5265 31 completed complete VBN cord-010092-uftc8inx 5265 32 apheresis apheresis NN cord-010092-uftc8inx 5265 33 procedures procedure NNS cord-010092-uftc8inx 5265 34 increased increase VBD cord-010092-uftc8inx 5265 35 from from IN cord-010092-uftc8inx 5265 36 89.8 89.8 CD cord-010092-uftc8inx 5265 37 % % NN cord-010092-uftc8inx 5265 38 to to IN cord-010092-uftc8inx 5265 39 92.4 92.4 CD cord-010092-uftc8inx 5265 40 % % NN cord-010092-uftc8inx 5265 41 ( ( -LRB- cord-010092-uftc8inx 5265 42 P p NN cord-010092-uftc8inx 5265 43 = = SYM cord-010092-uftc8inx 5265 44 0.083 0.083 CD cord-010092-uftc8inx 5265 45 ) ) -RRB- cord-010092-uftc8inx 5265 46 with with IN cord-010092-uftc8inx 5265 47 Trima Trima NNP cord-010092-uftc8inx 5265 48 Accel Accel NNP cord-010092-uftc8inx 5265 49 7 7 CD cord-010092-uftc8inx 5265 50 . . . cord-010092-uftc8inx 5266 1 Manual manual JJ cord-010092-uftc8inx 5266 2 transcription transcription NN cord-010092-uftc8inx 5266 3 of of IN cord-010092-uftc8inx 5266 4 data datum NNS cord-010092-uftc8inx 5266 5 during during IN cord-010092-uftc8inx 5266 6 the the DT cord-010092-uftc8inx 5266 7 procedure procedure NN cord-010092-uftc8inx 5266 8 was be VBD cord-010092-uftc8inx 5266 9 discontinued discontinue VBN cord-010092-uftc8inx 5266 10 with with IN cord-010092-uftc8inx 5266 11 the the DT cord-010092-uftc8inx 5266 12 implementation implementation NN cord-010092-uftc8inx 5266 13 of of IN cord-010092-uftc8inx 5266 14 Trima Trima NNP cord-010092-uftc8inx 5266 15 Accel Accel NNP cord-010092-uftc8inx 5266 16 7 7 CD cord-010092-uftc8inx 5266 17 with with IN cord-010092-uftc8inx 5266 18 TOMEs TOMEs NNPS cord-010092-uftc8inx 5266 19 . . . cord-010092-uftc8inx 5267 1 TOMEs TOMEs NNP cord-010092-uftc8inx 5267 2 captured capture VBD cord-010092-uftc8inx 5267 3 procedural procedural JJ cord-010092-uftc8inx 5267 4 data datum NNS cord-010092-uftc8inx 5267 5 and and CC cord-010092-uftc8inx 5267 6 operator operator NN cord-010092-uftc8inx 5267 7 steps step NNS cord-010092-uftc8inx 5267 8 with with IN cord-010092-uftc8inx 5267 9 barcode barcode NN cord-010092-uftc8inx 5267 10 scanning scanning NN cord-010092-uftc8inx 5267 11 and and CC cord-010092-uftc8inx 5267 12 tracking tracking NN cord-010092-uftc8inx 5267 13 of of IN cord-010092-uftc8inx 5267 14 configured configured JJ cord-010092-uftc8inx 5267 15 events event NNS cord-010092-uftc8inx 5267 16 . . . cord-010092-uftc8inx 5268 1 This this DT cord-010092-uftc8inx 5268 2 information information NN cord-010092-uftc8inx 5268 3 was be VBD cord-010092-uftc8inx 5268 4 transferred transfer VBN cord-010092-uftc8inx 5268 5 to to IN cord-010092-uftc8inx 5268 6 TOMEs TOMEs NNP cord-010092-uftc8inx 5268 7 post post NN cord-010092-uftc8inx 5268 8 procedure procedure NN cord-010092-uftc8inx 5268 9 and and CC cord-010092-uftc8inx 5268 10 printed print VBN cord-010092-uftc8inx 5268 11 as as IN cord-010092-uftc8inx 5268 12 a a DT cord-010092-uftc8inx 5268 13 final final JJ cord-010092-uftc8inx 5268 14 report report NN cord-010092-uftc8inx 5268 15 . . . cord-010092-uftc8inx 5269 1 Summary Summary NNP cord-010092-uftc8inx 5269 2 / / SYM cord-010092-uftc8inx 5269 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 5269 4 : : : cord-010092-uftc8inx 5270 1 Trima Trima NNP cord-010092-uftc8inx 5270 2 Accel Accel NNP cord-010092-uftc8inx 5270 3 7 7 CD cord-010092-uftc8inx 5270 4 significantly significantly RB cord-010092-uftc8inx 5270 5 decreased decrease VBD cord-010092-uftc8inx 5270 6 operator operator NN cord-010092-uftc8inx 5270 7 interventions intervention NNS cord-010092-uftc8inx 5270 8 , , , cord-010092-uftc8inx 5270 9 and and CC cord-010092-uftc8inx 5270 10 automated automate VBN cord-010092-uftc8inx 5270 11 data datum NNS cord-010092-uftc8inx 5270 12 capture capture NN cord-010092-uftc8inx 5270 13 with with IN cord-010092-uftc8inx 5270 14 TOMEs TOMEs NNPS cord-010092-uftc8inx 5270 15 eliminated eliminate VBN cord-010092-uftc8inx 5270 16 manual manual JJ cord-010092-uftc8inx 5270 17 transcription transcription NN cord-010092-uftc8inx 5270 18 of of IN cord-010092-uftc8inx 5270 19 data datum NNS cord-010092-uftc8inx 5270 20 . . . cord-010092-uftc8inx 5271 1 Both both DT cord-010092-uftc8inx 5271 2 outcomes outcome NNS cord-010092-uftc8inx 5271 3 freed free VBD cord-010092-uftc8inx 5271 4 operators operator NNS cord-010092-uftc8inx 5271 5 to to TO cord-010092-uftc8inx 5271 6 complete complete VB cord-010092-uftc8inx 5271 7 other other JJ cord-010092-uftc8inx 5271 8 tasks task NNS cord-010092-uftc8inx 5271 9 and and CC cord-010092-uftc8inx 5271 10 focus focus VB cord-010092-uftc8inx 5271 11 on on IN cord-010092-uftc8inx 5271 12 donor donor NN cord-010092-uftc8inx 5271 13 well well RB cord-010092-uftc8inx 5271 14 - - HYPH cord-010092-uftc8inx 5271 15 being being NN cord-010092-uftc8inx 5271 16 . . . cord-010092-uftc8inx 5272 1 Background background NN cord-010092-uftc8inx 5272 2 : : : cord-010092-uftc8inx 5273 1 The the DT cord-010092-uftc8inx 5273 2 European European NNP cord-010092-uftc8inx 5273 3 Committee Committee NNP cord-010092-uftc8inx 5273 4 ( ( -LRB- cord-010092-uftc8inx 5273 5 Partial Partial NNP cord-010092-uftc8inx 5273 6 Agreement Agreement NNP cord-010092-uftc8inx 5273 7 ) ) -RRB- cord-010092-uftc8inx 5273 8 on on IN cord-010092-uftc8inx 5273 9 Blood Blood NNP cord-010092-uftc8inx 5273 10 Transfusion Transfusion NNP cord-010092-uftc8inx 5273 11 ( ( -LRB- cord-010092-uftc8inx 5273 12 CD cd NN cord-010092-uftc8inx 5273 13 - - HYPH cord-010092-uftc8inx 5273 14 P p NN cord-010092-uftc8inx 5273 15 - - HYPH cord-010092-uftc8inx 5273 16 TS TS NNP cord-010092-uftc8inx 5273 17 ) ) -RRB- cord-010092-uftc8inx 5273 18 of of IN cord-010092-uftc8inx 5273 19 the the DT cord-010092-uftc8inx 5273 20 Council Council NNP cord-010092-uftc8inx 5273 21 of of IN cord-010092-uftc8inx 5273 22 Europe Europe NNP cord-010092-uftc8inx 5273 23 ( ( -LRB- cord-010092-uftc8inx 5273 24 CoE CoE NNP cord-010092-uftc8inx 5273 25 ) ) -RRB- cord-010092-uftc8inx 5273 26 has have VBZ cord-010092-uftc8inx 5273 27 appointed appoint VBN cord-010092-uftc8inx 5273 28 a a DT cord-010092-uftc8inx 5273 29 working work VBG cord-010092-uftc8inx 5273 30 group group NN cord-010092-uftc8inx 5273 31 ( ( -LRB- cord-010092-uftc8inx 5273 32 WG WG NNP cord-010092-uftc8inx 5273 33 ) ) -RRB- cord-010092-uftc8inx 5273 34 to to TO cord-010092-uftc8inx 5273 35 focus focus VB cord-010092-uftc8inx 5273 36 on on IN cord-010092-uftc8inx 5273 37 issues issue NNS cord-010092-uftc8inx 5273 38 with with IN cord-010092-uftc8inx 5273 39 plasma plasma NN cord-010092-uftc8inx 5273 40 supply supply NN cord-010092-uftc8inx 5273 41 management management NN cord-010092-uftc8inx 5273 42 ( ( -LRB- cord-010092-uftc8inx 5273 43 PSM PSM NNP cord-010092-uftc8inx 5273 44 ) ) -RRB- cord-010092-uftc8inx 5273 45 . . . cord-010092-uftc8inx 5274 1 The the DT cord-010092-uftc8inx 5274 2 task task NN cord-010092-uftc8inx 5274 3 of of IN cord-010092-uftc8inx 5274 4 the the DT cord-010092-uftc8inx 5274 5 WG WG NNP cord-010092-uftc8inx 5274 6 is be VBZ cord-010092-uftc8inx 5274 7 , , , cord-010092-uftc8inx 5274 8 among among IN cord-010092-uftc8inx 5274 9 others other NNS cord-010092-uftc8inx 5274 10 , , , cord-010092-uftc8inx 5274 11 to to TO cord-010092-uftc8inx 5274 12 collect collect VB cord-010092-uftc8inx 5274 13 and and CC cord-010092-uftc8inx 5274 14 analyze analyze VB cord-010092-uftc8inx 5274 15 data datum NNS cord-010092-uftc8inx 5274 16 in in IN cord-010092-uftc8inx 5274 17 order order NN cord-010092-uftc8inx 5274 18 to to TO cord-010092-uftc8inx 5274 19 fill fill VB cord-010092-uftc8inx 5274 20 knowledge knowledge NN cord-010092-uftc8inx 5274 21 gaps gap NNS cord-010092-uftc8inx 5274 22 concerning concern VBG cord-010092-uftc8inx 5274 23 donor donor NN cord-010092-uftc8inx 5274 24 safety safety NN cord-010092-uftc8inx 5274 25 in in IN cord-010092-uftc8inx 5274 26 plasmapheresis plasmapheresis NN cord-010092-uftc8inx 5274 27 . . . cord-010092-uftc8inx 5275 1 In in IN cord-010092-uftc8inx 5275 2 doing do VBG cord-010092-uftc8inx 5275 3 so so RB cord-010092-uftc8inx 5275 4 , , , cord-010092-uftc8inx 5275 5 the the DT cord-010092-uftc8inx 5275 6 working work VBG cord-010092-uftc8inx 5275 7 group group NN cord-010092-uftc8inx 5275 8 will will MD cord-010092-uftc8inx 5275 9 gather gather VB cord-010092-uftc8inx 5275 10 evidence evidence NN cord-010092-uftc8inx 5275 11 base base NN cord-010092-uftc8inx 5275 12 data datum NNS cord-010092-uftc8inx 5275 13 to to TO cord-010092-uftc8inx 5275 14 support support VB cord-010092-uftc8inx 5275 15 the the DT cord-010092-uftc8inx 5275 16 upcoming upcoming JJ cord-010092-uftc8inx 5275 17 revision revision NN cord-010092-uftc8inx 5275 18 of of IN cord-010092-uftc8inx 5275 19 the the DT cord-010092-uftc8inx 5275 20 19 19 CD cord-010092-uftc8inx 5275 21 th th XX cord-010092-uftc8inx 5275 22 edition edition NN cord-010092-uftc8inx 5275 23 of of IN cord-010092-uftc8inx 5275 24 CoE CoE NNP cord-010092-uftc8inx 5275 25 's 's POS cord-010092-uftc8inx 5275 26 " " `` cord-010092-uftc8inx 5275 27 Guide Guide NNP cord-010092-uftc8inx 5275 28 to to IN cord-010092-uftc8inx 5275 29 the the DT cord-010092-uftc8inx 5275 30 preparation preparation NN cord-010092-uftc8inx 5275 31 , , , cord-010092-uftc8inx 5275 32 use use NN cord-010092-uftc8inx 5275 33 and and CC cord-010092-uftc8inx 5275 34 quality quality NN cord-010092-uftc8inx 5275 35 assurance assurance NN cord-010092-uftc8inx 5275 36 of of IN cord-010092-uftc8inx 5275 37 blood blood NN cord-010092-uftc8inx 5275 38 components component NNS cord-010092-uftc8inx 5275 39 " " '' cord-010092-uftc8inx 5275 40 , , , cord-010092-uftc8inx 5275 41 the the DT cord-010092-uftc8inx 5275 42 Blood Blood NNP cord-010092-uftc8inx 5275 43 Guide Guide NNP cord-010092-uftc8inx 5275 44 . . . cord-010092-uftc8inx 5276 1 An an DT cord-010092-uftc8inx 5276 2 international international JJ cord-010092-uftc8inx 5276 3 survey survey NN cord-010092-uftc8inx 5276 4 was be VBD cord-010092-uftc8inx 5276 5 conducted conduct VBN cord-010092-uftc8inx 5276 6 Sept Sept NNP cord-010092-uftc8inx 5276 7 - - HYPH cord-010092-uftc8inx 5276 8 Dec Dec NNP cord-010092-uftc8inx 5276 9 2017 2017 CD cord-010092-uftc8inx 5276 10 , , , cord-010092-uftc8inx 5276 11 distributed distribute VBN cord-010092-uftc8inx 5276 12 to to IN cord-010092-uftc8inx 5276 13 blood blood NN cord-010092-uftc8inx 5276 14 establishments establishment NNS cord-010092-uftc8inx 5276 15 ( ( -LRB- cord-010092-uftc8inx 5276 16 BEs be NNS cord-010092-uftc8inx 5276 17 ) ) -RRB- cord-010092-uftc8inx 5276 18 by by IN cord-010092-uftc8inx 5276 19 the the DT cord-010092-uftc8inx 5276 20 CD CD NNP cord-010092-uftc8inx 5276 21 - - HYPH cord-010092-uftc8inx 5276 22 P p NN cord-010092-uftc8inx 5276 23 - - HYPH cord-010092-uftc8inx 5276 24 TS TS NNP cord-010092-uftc8inx 5276 25 representatives representative NNS cord-010092-uftc8inx 5276 26 to to IN cord-010092-uftc8inx 5276 27 CoE CoE NNP cord-010092-uftc8inx 5276 28 's 's POS cord-010092-uftc8inx 5276 29 member member NN cord-010092-uftc8inx 5276 30 and and CC cord-010092-uftc8inx 5276 31 observer observer NN cord-010092-uftc8inx 5276 32 states state NNS cord-010092-uftc8inx 5276 33 . . . cord-010092-uftc8inx 5277 1 The the DT cord-010092-uftc8inx 5277 2 questionnaire questionnaire NN cord-010092-uftc8inx 5277 3 included include VBD cord-010092-uftc8inx 5277 4 sections section NNS cord-010092-uftc8inx 5277 5 covering cover VBG cord-010092-uftc8inx 5277 6 collection collection NN cord-010092-uftc8inx 5277 7 practices practice NNS cord-010092-uftc8inx 5277 8 ( ( -LRB- cord-010092-uftc8inx 5277 9 volume volume NN cord-010092-uftc8inx 5277 10 and and CC cord-010092-uftc8inx 5277 11 frequency frequency NN cord-010092-uftc8inx 5277 12 ) ) -RRB- cord-010092-uftc8inx 5277 13 , , , cord-010092-uftc8inx 5277 14 management management NN cord-010092-uftc8inx 5277 15 of of IN cord-010092-uftc8inx 5277 16 red red JJ cord-010092-uftc8inx 5277 17 cell cell NN cord-010092-uftc8inx 5277 18 loss loss NN cord-010092-uftc8inx 5277 19 , , , cord-010092-uftc8inx 5277 20 donor donor NN cord-010092-uftc8inx 5277 21 panel panel NN cord-010092-uftc8inx 5277 22 demographics demographic NNS cord-010092-uftc8inx 5277 23 and and CC cord-010092-uftc8inx 5277 24 data datum NNS cord-010092-uftc8inx 5277 25 on on IN cord-010092-uftc8inx 5277 26 donor donor NN cord-010092-uftc8inx 5277 27 adverse adverse JJ cord-010092-uftc8inx 5277 28 events event NNS cord-010092-uftc8inx 5277 29 . . . cord-010092-uftc8inx 5278 1 Aims aim VBZ cord-010092-uftc8inx 5278 2 : : : cord-010092-uftc8inx 5279 1 The the DT cord-010092-uftc8inx 5279 2 aim aim NN cord-010092-uftc8inx 5279 3 of of IN cord-010092-uftc8inx 5279 4 this this DT cord-010092-uftc8inx 5279 5 study study NN cord-010092-uftc8inx 5279 6 was be VBD cord-010092-uftc8inx 5279 7 to to TO cord-010092-uftc8inx 5279 8 investigate investigate VB cord-010092-uftc8inx 5279 9 whether whether IN cord-010092-uftc8inx 5279 10 collection collection NN cord-010092-uftc8inx 5279 11 practices practice NNS cord-010092-uftc8inx 5279 12 following follow VBG cord-010092-uftc8inx 5279 13 the the DT cord-010092-uftc8inx 5279 14 recommendations recommendation NNS cord-010092-uftc8inx 5279 15 published publish VBN cord-010092-uftc8inx 5279 16 in in IN cord-010092-uftc8inx 5279 17 the the DT cord-010092-uftc8inx 5279 18 Blood Blood NNP cord-010092-uftc8inx 5279 19 Guide Guide NNP cord-010092-uftc8inx 5279 20 for for IN cord-010092-uftc8inx 5279 21 maximal maximal JJ cord-010092-uftc8inx 5279 22 collection collection NN cord-010092-uftc8inx 5279 23 volumes volume NNS cord-010092-uftc8inx 5279 24 and and CC cord-010092-uftc8inx 5279 25 number number NN cord-010092-uftc8inx 5279 26 of of IN cord-010092-uftc8inx 5279 27 donations donation NNS cord-010092-uftc8inx 5279 28 per per IN cord-010092-uftc8inx 5279 29 year year NN cord-010092-uftc8inx 5279 30 were be VBD cord-010092-uftc8inx 5279 31 indeed indeed RB cord-010092-uftc8inx 5279 32 associated associate VBN cord-010092-uftc8inx 5279 33 with with IN cord-010092-uftc8inx 5279 34 higher high JJR cord-010092-uftc8inx 5279 35 levels level NNS cord-010092-uftc8inx 5279 36 of of IN cord-010092-uftc8inx 5279 37 donor donor NN cord-010092-uftc8inx 5279 38 safety safety NN cord-010092-uftc8inx 5279 39 and and CC cord-010092-uftc8inx 5279 40 improved improved JJ cord-010092-uftc8inx 5279 41 donor donor NN cord-010092-uftc8inx 5279 42 base base NN cord-010092-uftc8inx 5279 43 sustainability sustainability NN cord-010092-uftc8inx 5279 44 . . . cord-010092-uftc8inx 5280 1 Methods method NNS cord-010092-uftc8inx 5280 2 : : : cord-010092-uftc8inx 5280 3 From from IN cord-010092-uftc8inx 5280 4 the the DT cord-010092-uftc8inx 5280 5 total total NN cord-010092-uftc8inx 5280 6 of of IN cord-010092-uftc8inx 5280 7 36 36 CD cord-010092-uftc8inx 5280 8 respondents respondent NNS cord-010092-uftc8inx 5280 9 , , , cord-010092-uftc8inx 5280 10 24 24 CD cord-010092-uftc8inx 5280 11 BEs be NNS cord-010092-uftc8inx 5280 12 collected collect VBD cord-010092-uftc8inx 5280 13 plasma plasma NN cord-010092-uftc8inx 5280 14 for for IN cord-010092-uftc8inx 5280 15 fractionation fractionation NN cord-010092-uftc8inx 5280 16 ( ( -LRB- cord-010092-uftc8inx 5280 17 PfF pff NN cord-010092-uftc8inx 5280 18 ) ) -RRB- cord-010092-uftc8inx 5280 19 by by IN cord-010092-uftc8inx 5280 20 apheresis apheresis NN cord-010092-uftc8inx 5280 21 and and CC cord-010092-uftc8inx 5280 22 the the DT cord-010092-uftc8inx 5280 23 study study NN cord-010092-uftc8inx 5280 24 had have VBD cord-010092-uftc8inx 5280 25 a a DT cord-010092-uftc8inx 5280 26 dataset dataset NN cord-010092-uftc8inx 5280 27 covering cover VBG cord-010092-uftc8inx 5280 28 2,888,390 2,888,390 CD cord-010092-uftc8inx 5280 29 plasma plasma NN cord-010092-uftc8inx 5280 30 donations donation NNS cord-010092-uftc8inx 5280 31 in in IN cord-010092-uftc8inx 5280 32 the the DT cord-010092-uftc8inx 5280 33 latest late JJS cord-010092-uftc8inx 5280 34 fiscal fiscal JJ cord-010092-uftc8inx 5280 35 year year NN cord-010092-uftc8inx 5280 36 ( ( -LRB- cord-010092-uftc8inx 5280 37 LFY LFY NNP cord-010092-uftc8inx 5280 38 ) ) -RRB- cord-010092-uftc8inx 5280 39 . . . cord-010092-uftc8inx 5281 1 The the DT cord-010092-uftc8inx 5281 2 parameter parameter NN cord-010092-uftc8inx 5281 3 used use VBN cord-010092-uftc8inx 5281 4 as as IN cord-010092-uftc8inx 5281 5 marker marker NN cord-010092-uftc8inx 5281 6 of of IN cord-010092-uftc8inx 5281 7 donor donor NN cord-010092-uftc8inx 5281 8 safety safety NN cord-010092-uftc8inx 5281 9 was be VBD cord-010092-uftc8inx 5281 10 the the DT cord-010092-uftc8inx 5281 11 rate rate NN cord-010092-uftc8inx 5281 12 of of IN cord-010092-uftc8inx 5281 13 immediate immediate JJ cord-010092-uftc8inx 5281 14 vasovagal vasovagal JJ cord-010092-uftc8inx 5281 15 reactions reaction NNS cord-010092-uftc8inx 5281 16 with with IN cord-010092-uftc8inx 5281 17 loss loss NN cord-010092-uftc8inx 5281 18 of of IN cord-010092-uftc8inx 5281 19 consciousness consciousness NN cord-010092-uftc8inx 5281 20 ( ( -LRB- cord-010092-uftc8inx 5281 21 VVR vvr NN cord-010092-uftc8inx 5281 22 with with IN cord-010092-uftc8inx 5281 23 LOC LOC NNP cord-010092-uftc8inx 5281 24 ) ) -RRB- cord-010092-uftc8inx 5281 25 per per IN cord-010092-uftc8inx 5281 26 10,000 10,000 CD cord-010092-uftc8inx 5281 27 plasma plasma NN cord-010092-uftc8inx 5281 28 collections collection NNS cord-010092-uftc8inx 5281 29 . . . cord-010092-uftc8inx 5282 1 The the DT cord-010092-uftc8inx 5282 2 parameter parameter NN cord-010092-uftc8inx 5282 3 used use VBN cord-010092-uftc8inx 5282 4 as as IN cord-010092-uftc8inx 5282 5 marker marker NN cord-010092-uftc8inx 5282 6 of of IN cord-010092-uftc8inx 5282 7 donor donor NN cord-010092-uftc8inx 5282 8 base base NN cord-010092-uftc8inx 5282 9 sustainability sustainability NN cord-010092-uftc8inx 5282 10 was be VBD cord-010092-uftc8inx 5282 11 the the DT cord-010092-uftc8inx 5282 12 retention retention NN cord-010092-uftc8inx 5282 13 rate rate NN cord-010092-uftc8inx 5282 14 of of IN cord-010092-uftc8inx 5282 15 donors donor NNS cord-010092-uftc8inx 5282 16 , , , cord-010092-uftc8inx 5282 17 ie ie LS cord-010092-uftc8inx 5282 18 % % NN cord-010092-uftc8inx 5282 19 donors donor NNS cord-010092-uftc8inx 5282 20 active active JJ cord-010092-uftc8inx 5282 21 in in IN cord-010092-uftc8inx 5282 22 the the DT cord-010092-uftc8inx 5282 23 previous previous JJ cord-010092-uftc8inx 5282 24 year year NN cord-010092-uftc8inx 5282 25 returning return VBG cord-010092-uftc8inx 5282 26 to to TO cord-010092-uftc8inx 5282 27 make make VB cord-010092-uftc8inx 5282 28 a a DT cord-010092-uftc8inx 5282 29 donation donation NN cord-010092-uftc8inx 5282 30 in in IN cord-010092-uftc8inx 5282 31 the the DT cord-010092-uftc8inx 5282 32 LFY LFY NNP cord-010092-uftc8inx 5282 33 . . . cord-010092-uftc8inx 5283 1 Results result NNS cord-010092-uftc8inx 5283 2 : : : cord-010092-uftc8inx 5284 1 In in IN cord-010092-uftc8inx 5284 2 the the DT cord-010092-uftc8inx 5284 3 Blood Blood NNP cord-010092-uftc8inx 5284 4 Guide Guide NNP cord-010092-uftc8inx 5284 5 , , , cord-010092-uftc8inx 5284 6 the the DT cord-010092-uftc8inx 5284 7 collection collection NN cord-010092-uftc8inx 5284 8 volume volume NN cord-010092-uftc8inx 5284 9 per per IN cord-010092-uftc8inx 5284 10 apheresis apheresis NN cord-010092-uftc8inx 5284 11 is be VBZ cord-010092-uftc8inx 5284 12 limited limit VBN cord-010092-uftc8inx 5284 13 to to IN cord-010092-uftc8inx 5284 14 16 16 CD cord-010092-uftc8inx 5284 15 % % NN cord-010092-uftc8inx 5284 16 of of IN cord-010092-uftc8inx 5284 17 the the DT cord-010092-uftc8inx 5284 18 estimated estimate VBN cord-010092-uftc8inx 5284 19 total total JJ cord-010092-uftc8inx 5284 20 blood blood NN cord-010092-uftc8inx 5284 21 volume volume NN cord-010092-uftc8inx 5284 22 but but CC cord-010092-uftc8inx 5284 23 maximally maximally RB cord-010092-uftc8inx 5284 24 750 750 CD cord-010092-uftc8inx 5284 25 mL ml NN cord-010092-uftc8inx 5284 26 , , , cord-010092-uftc8inx 5284 27 including include VBG cord-010092-uftc8inx 5284 28 anticoagulant anticoagulant NN cord-010092-uftc8inx 5284 29 . . . cord-010092-uftc8inx 5285 1 Respondents respondent NNS cord-010092-uftc8inx 5285 2 had have VBD cord-010092-uftc8inx 5285 3 differing differ VBG cord-010092-uftc8inx 5285 4 practices practice NNS cord-010092-uftc8inx 5285 5 and and CC cord-010092-uftc8inx 5285 6 scale scale NN cord-010092-uftc8inx 5285 7 of of IN cord-010092-uftc8inx 5285 8 collection collection NN cord-010092-uftc8inx 5285 9 program program NN cord-010092-uftc8inx 5285 10 15 15 CD cord-010092-uftc8inx 5285 11 BE be NN cord-010092-uftc8inx 5285 12 were be VBD cord-010092-uftc8inx 5285 13 aligned align VBN cord-010092-uftc8inx 5285 14 or or CC cord-010092-uftc8inx 5285 15 lower low JJR cord-010092-uftc8inx 5285 16 , , , cord-010092-uftc8inx 5285 17 and and CC cord-010092-uftc8inx 5285 18 9 9 CD cord-010092-uftc8inx 5285 19 BE be VB cord-010092-uftc8inx 5285 20 had have VBD cord-010092-uftc8inx 5285 21 higher high JJR cord-010092-uftc8inx 5285 22 collection collection NN cord-010092-uftc8inx 5285 23 volumes volume NNS cord-010092-uftc8inx 5285 24 . . . cord-010092-uftc8inx 5286 1 Altogether altogether RB cord-010092-uftc8inx 5286 2 14 14 CD cord-010092-uftc8inx 5286 3 reported report VBD cord-010092-uftc8inx 5286 4 the the DT cord-010092-uftc8inx 5286 5 immediate immediate JJ cord-010092-uftc8inx 5286 6 VVR vvr NN cord-010092-uftc8inx 5286 7 with with IN cord-010092-uftc8inx 5286 8 LOC loc NN cord-010092-uftc8inx 5286 9 rate rate NN cord-010092-uftc8inx 5286 10 , , , cord-010092-uftc8inx 5286 11 which which WDT cord-010092-uftc8inx 5286 12 mainly mainly RB cord-010092-uftc8inx 5286 13 was be VBD cord-010092-uftc8inx 5286 14 lower low JJR cord-010092-uftc8inx 5286 15 than than IN cord-010092-uftc8inx 5286 16 10/10000 10/10000 CD cord-010092-uftc8inx 5286 17 collections collection NNS cord-010092-uftc8inx 5286 18 . . . cord-010092-uftc8inx 5287 1 There there EX cord-010092-uftc8inx 5287 2 was be VBD cord-010092-uftc8inx 5287 3 a a DT cord-010092-uftc8inx 5287 4 small small JJ cord-010092-uftc8inx 5287 5 trend trend NN cord-010092-uftc8inx 5287 6 towards towards IN cord-010092-uftc8inx 5287 7 reduced reduce VBN cord-010092-uftc8inx 5287 8 rate rate NN cord-010092-uftc8inx 5287 9 with with IN cord-010092-uftc8inx 5287 10 larger large JJR cord-010092-uftc8inx 5287 11 collection collection NN cord-010092-uftc8inx 5287 12 volumes volume NNS cord-010092-uftc8inx 5287 13 than than IN cord-010092-uftc8inx 5287 14 allowed allow VBN cord-010092-uftc8inx 5287 15 by by IN cord-010092-uftc8inx 5287 16 the the DT cord-010092-uftc8inx 5287 17 current current JJ cord-010092-uftc8inx 5287 18 Blood Blood NNP cord-010092-uftc8inx 5287 19 Guide Guide NNP cord-010092-uftc8inx 5287 20 . . . cord-010092-uftc8inx 5288 1 Saline saline NN cord-010092-uftc8inx 5288 2 compensation compensation NN cord-010092-uftc8inx 5288 3 during during IN cord-010092-uftc8inx 5288 4 or or CC cord-010092-uftc8inx 5288 5 after after IN cord-010092-uftc8inx 5288 6 collection collection NN cord-010092-uftc8inx 5288 7 did do VBD cord-010092-uftc8inx 5288 8 not not RB cord-010092-uftc8inx 5288 9 affect affect VB cord-010092-uftc8inx 5288 10 the the DT cord-010092-uftc8inx 5288 11 rate rate NN cord-010092-uftc8inx 5288 12 of of IN cord-010092-uftc8inx 5288 13 VVR vvr NN cord-010092-uftc8inx 5288 14 with with IN cord-010092-uftc8inx 5288 15 LOC LOC NNP cord-010092-uftc8inx 5288 16 . . . cord-010092-uftc8inx 5289 1 No no DT cord-010092-uftc8inx 5289 2 correlation correlation NN cord-010092-uftc8inx 5289 3 was be VBD cord-010092-uftc8inx 5289 4 observed observe VBN cord-010092-uftc8inx 5289 5 between between IN cord-010092-uftc8inx 5289 6 the the DT cord-010092-uftc8inx 5289 7 annual annual JJ cord-010092-uftc8inx 5289 8 donor donor NN cord-010092-uftc8inx 5289 9 retention retention NN cord-010092-uftc8inx 5289 10 rate rate NN cord-010092-uftc8inx 5289 11 and and CC cord-010092-uftc8inx 5289 12 the the DT cord-010092-uftc8inx 5289 13 rate rate NN cord-010092-uftc8inx 5289 14 of of IN cord-010092-uftc8inx 5289 15 VVR vvr NN cord-010092-uftc8inx 5289 16 with with IN cord-010092-uftc8inx 5289 17 LOC LOC NNP cord-010092-uftc8inx 5289 18 or or CC cord-010092-uftc8inx 5289 19 saline saline NN cord-010092-uftc8inx 5289 20 compensation compensation NN cord-010092-uftc8inx 5289 21 practices practice NNS cord-010092-uftc8inx 5289 22 , , , cord-010092-uftc8inx 5289 23 as as IN cord-010092-uftc8inx 5289 24 reported report VBN cord-010092-uftc8inx 5289 25 by by IN cord-010092-uftc8inx 5289 26 16 16 CD cord-010092-uftc8inx 5289 27 respondents respondent NNS cord-010092-uftc8inx 5289 28 . . . cord-010092-uftc8inx 5290 1 The the DT cord-010092-uftc8inx 5290 2 retention retention NN cord-010092-uftc8inx 5290 3 rate rate NN cord-010092-uftc8inx 5290 4 banded band VBN cord-010092-uftc8inx 5290 5 in in IN cord-010092-uftc8inx 5290 6 the the DT cord-010092-uftc8inx 5290 7 range range NN cord-010092-uftc8inx 5290 8 of of IN cord-010092-uftc8inx 5290 9 50%>80 50%>80 CD cord-010092-uftc8inx 5290 10 % % NN cord-010092-uftc8inx 5290 11 ( ( -LRB- cord-010092-uftc8inx 5290 12 mean mean UH cord-010092-uftc8inx 5290 13 = = SYM cord-010092-uftc8inx 5290 14 60 60 CD cord-010092-uftc8inx 5290 15 % % NN cord-010092-uftc8inx 5290 16 , , , cord-010092-uftc8inx 5290 17 min min NN cord-010092-uftc8inx 5290 18 = = SYM cord-010092-uftc8inx 5290 19 25 25 CD cord-010092-uftc8inx 5290 20 % % NN cord-010092-uftc8inx 5290 21 , , , cord-010092-uftc8inx 5290 22 interquartile interquartile JJ cord-010092-uftc8inx 5290 23 range range NN cord-010092-uftc8inx 5290 24 = = SYM cord-010092-uftc8inx 5290 25 14 14 CD cord-010092-uftc8inx 5290 26 % % NN cord-010092-uftc8inx 5290 27 , , , cord-010092-uftc8inx 5290 28 max max NNP cord-010092-uftc8inx 5290 29 = = SYM cord-010092-uftc8inx 5290 30 90 90 CD cord-010092-uftc8inx 5290 31 % % NN cord-010092-uftc8inx 5290 32 ) ) -RRB- cord-010092-uftc8inx 5290 33 . . . cord-010092-uftc8inx 5291 1 The the DT cord-010092-uftc8inx 5291 2 association association NN cord-010092-uftc8inx 5291 3 between between IN cord-010092-uftc8inx 5291 4 maximum maximum JJ cord-010092-uftc8inx 5291 5 allowed allow VBN cord-010092-uftc8inx 5291 6 yearly yearly JJ cord-010092-uftc8inx 5291 7 plasma plasma NN cord-010092-uftc8inx 5291 8 collection collection NN cord-010092-uftc8inx 5291 9 ( ( -LRB- cord-010092-uftc8inx 5291 10 25 25 CD cord-010092-uftc8inx 5291 11 L l NN cord-010092-uftc8inx 5291 12 ) ) -RRB- cord-010092-uftc8inx 5291 13 appears appear VBZ cord-010092-uftc8inx 5291 14 to to TO cord-010092-uftc8inx 5291 15 be be VB cord-010092-uftc8inx 5291 16 reasonably reasonably RB cord-010092-uftc8inx 5291 17 constant constant JJ cord-010092-uftc8inx 5291 18 and and CC cord-010092-uftc8inx 5291 19 showed show VBD cord-010092-uftc8inx 5291 20 no no DT cord-010092-uftc8inx 5291 21 clear clear JJ cord-010092-uftc8inx 5291 22 association association NN cord-010092-uftc8inx 5291 23 with with IN cord-010092-uftc8inx 5291 24 the the DT cord-010092-uftc8inx 5291 25 donor donor NN cord-010092-uftc8inx 5291 26 retention retention NN cord-010092-uftc8inx 5291 27 rate rate NN cord-010092-uftc8inx 5291 28 . . . cord-010092-uftc8inx 5292 1 Summary Summary NNP cord-010092-uftc8inx 5292 2 / / SYM cord-010092-uftc8inx 5292 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 5292 4 : : : cord-010092-uftc8inx 5293 1 Restricting restrict VBG cord-010092-uftc8inx 5293 2 the the DT cord-010092-uftc8inx 5293 3 maximum maximum JJ cord-010092-uftc8inx 5293 4 collection collection NN cord-010092-uftc8inx 5293 5 limit limit NN cord-010092-uftc8inx 5293 6 according accord VBG cord-010092-uftc8inx 5293 7 to to IN cord-010092-uftc8inx 5293 8 the the DT cord-010092-uftc8inx 5293 9 current current JJ cord-010092-uftc8inx 5293 10 Blood Blood NNP cord-010092-uftc8inx 5293 11 Guide Guide NNP cord-010092-uftc8inx 5293 12 was be VBD cord-010092-uftc8inx 5293 13 not not RB cord-010092-uftc8inx 5293 14 associated associate VBN cord-010092-uftc8inx 5293 15 with with IN cord-010092-uftc8inx 5293 16 either either DT cord-010092-uftc8inx 5293 17 lower low JJR cord-010092-uftc8inx 5293 18 VVR vvr NN cord-010092-uftc8inx 5293 19 with with IN cord-010092-uftc8inx 5293 20 LOC LOC NNP cord-010092-uftc8inx 5293 21 or or CC cord-010092-uftc8inx 5293 22 with with IN cord-010092-uftc8inx 5293 23 higher high JJR cord-010092-uftc8inx 5293 24 donor donor NN cord-010092-uftc8inx 5293 25 retention retention NN cord-010092-uftc8inx 5293 26 rate rate NN cord-010092-uftc8inx 5293 27 . . . cord-010092-uftc8inx 5294 1 This this DT cord-010092-uftc8inx 5294 2 study study NN cord-010092-uftc8inx 5294 3 supports support VBZ cord-010092-uftc8inx 5294 4 reassessment reassessment NN cord-010092-uftc8inx 5294 5 of of IN cord-010092-uftc8inx 5294 6 current current JJ cord-010092-uftc8inx 5294 7 Blood Blood NNP cord-010092-uftc8inx 5294 8 Guide Guide NNP cord-010092-uftc8inx 5294 9 0 0 NFP cord-010092-uftc8inx 5294 10 s s POS cord-010092-uftc8inx 5294 11 limits limit NNS cord-010092-uftc8inx 5294 12 for for IN cord-010092-uftc8inx 5294 13 collection collection NN cord-010092-uftc8inx 5294 14 volume volume NN cord-010092-uftc8inx 5294 15 of of IN cord-010092-uftc8inx 5294 16 maximum maximum NN cord-010092-uftc8inx 5294 17 of of IN cord-010092-uftc8inx 5294 18 750 750 CD cord-010092-uftc8inx 5294 19 mL ml NN cord-010092-uftc8inx 5294 20 per per IN cord-010092-uftc8inx 5294 21 donation donation NN cord-010092-uftc8inx 5294 22 and and CC cord-010092-uftc8inx 5294 23 25 25 CD cord-010092-uftc8inx 5294 24 L l NN cord-010092-uftc8inx 5294 25 per per IN cord-010092-uftc8inx 5294 26 year year NN cord-010092-uftc8inx 5294 27 per per IN cord-010092-uftc8inx 5294 28 donor donor NN cord-010092-uftc8inx 5294 29 . . . cord-010092-uftc8inx 5295 1 Methods method NNS cord-010092-uftc8inx 5295 2 : : : cord-010092-uftc8inx 5296 1 Serum serum NN cord-010092-uftc8inx 5296 2 ferritin ferritin NN cord-010092-uftc8inx 5296 3 concentrations concentration NNS cord-010092-uftc8inx 5296 4 were be VBD cord-010092-uftc8inx 5296 5 established establish VBN cord-010092-uftc8inx 5296 6 from from IN cord-010092-uftc8inx 5296 7 sera sera NNP cord-010092-uftc8inx 5296 8 stored store VBN cord-010092-uftc8inx 5296 9 at at IN cord-010092-uftc8inx 5296 10 À30 À30 NNP cord-010092-uftc8inx 5296 11 ° ° NN cord-010092-uftc8inx 5296 12 C C NNP cord-010092-uftc8inx 5296 13 from from IN cord-010092-uftc8inx 5296 14 repetitive repetitive JJ cord-010092-uftc8inx 5296 15 platelet platelet NN cord-010092-uftc8inx 5296 16 donors donor NNS cord-010092-uftc8inx 5296 17 between between IN cord-010092-uftc8inx 5296 18 2014 2014 CD cord-010092-uftc8inx 5296 19 and and CC cord-010092-uftc8inx 5296 20 2016 2016 CD cord-010092-uftc8inx 5296 21 , , , cord-010092-uftc8inx 5296 22 using use VBG cord-010092-uftc8inx 5296 23 ARCHITECT ARCHITECT NNP cord-010092-uftc8inx 5296 24 â â CD cord-010092-uftc8inx 5296 25 Ferritin ferritin NN cord-010092-uftc8inx 5296 26 assay assay NN cord-010092-uftc8inx 5296 27 Chemiluminescent Chemiluminescent NNP cord-010092-uftc8inx 5296 28 Microparticle Microparticle NNP cord-010092-uftc8inx 5296 29 Immunoassay Immunoassay NNP cord-010092-uftc8inx 5296 30 ( ( -LRB- cord-010092-uftc8inx 5296 31 CMIA CMIA NNP cord-010092-uftc8inx 5296 32 ) ) -RRB- cord-010092-uftc8inx 5296 33 . . . cord-010092-uftc8inx 5297 1 The the DT cord-010092-uftc8inx 5297 2 hematimetric hematimetric NN cord-010092-uftc8inx 5297 3 parameters parameter NNS cord-010092-uftc8inx 5297 4 were be VBD cord-010092-uftc8inx 5297 5 evaluated evaluate VBN cord-010092-uftc8inx 5297 6 in in IN cord-010092-uftc8inx 5297 7 a a DT cord-010092-uftc8inx 5297 8 total total JJ cord-010092-uftc8inx 5297 9 blood blood NN cord-010092-uftc8inx 5297 10 sample sample NN cord-010092-uftc8inx 5297 11 using use VBG cord-010092-uftc8inx 5297 12 the the DT cord-010092-uftc8inx 5297 13 Celldyn Celldyn NNP cord-010092-uftc8inx 5297 14 1800 1800 CD cord-010092-uftc8inx 5297 15 â â NN cord-010092-uftc8inx 5297 16 . . . cord-010092-uftc8inx 5298 1 Sixteen sixteen CD cord-010092-uftc8inx 5298 2 samples sample NNS cord-010092-uftc8inx 5298 3 were be VBD cord-010092-uftc8inx 5298 4 obtained obtain VBN cord-010092-uftc8inx 5298 5 from from IN cord-010092-uftc8inx 5298 6 women woman NNS cord-010092-uftc8inx 5298 7 ( ( -LRB- cord-010092-uftc8inx 5298 8 age age NN cord-010092-uftc8inx 5298 9 : : : cord-010092-uftc8inx 5298 10 35.3 35.3 CD cord-010092-uftc8inx 5298 11 AE AE NNP cord-010092-uftc8inx 5298 12 12.4 12.4 CD cord-010092-uftc8inx 5298 13 years year NNS cord-010092-uftc8inx 5298 14 , , , cord-010092-uftc8inx 5298 15 range range NN cord-010092-uftc8inx 5298 16 : : : cord-010092-uftc8inx 5298 17 18 18 CD cord-010092-uftc8inx 5298 18 - - SYM cord-010092-uftc8inx 5298 19 61 61 CD cord-010092-uftc8inx 5298 20 ) ) -RRB- cord-010092-uftc8inx 5298 21 and and CC cord-010092-uftc8inx 5298 22 35 35 CD cord-010092-uftc8inx 5298 23 samples sample NNS cord-010092-uftc8inx 5298 24 from from IN cord-010092-uftc8inx 5298 25 men man NNS cord-010092-uftc8inx 5298 26 ( ( -LRB- cord-010092-uftc8inx 5298 27 age age NN cord-010092-uftc8inx 5298 28 : : : cord-010092-uftc8inx 5298 29 36.2 36.2 CD cord-010092-uftc8inx 5298 30 AE AE NNP cord-010092-uftc8inx 5298 31 9.4 9.4 CD cord-010092-uftc8inx 5298 32 years year NNS cord-010092-uftc8inx 5298 33 , , , cord-010092-uftc8inx 5298 34 range range VBP cord-010092-uftc8inx 5298 35 20 20 CD cord-010092-uftc8inx 5298 36 - - SYM cord-010092-uftc8inx 5298 37 61 61 CD cord-010092-uftc8inx 5298 38 ) ) -RRB- cord-010092-uftc8inx 5298 39 , , , cord-010092-uftc8inx 5298 40 corresponding correspond VBG cord-010092-uftc8inx 5298 41 to to IN cord-010092-uftc8inx 5298 42 55.2 55.2 CD cord-010092-uftc8inx 5298 43 % % NN cord-010092-uftc8inx 5298 44 and and CC cord-010092-uftc8inx 5298 45 37.2 37.2 CD cord-010092-uftc8inx 5298 46 % % NN cord-010092-uftc8inx 5298 47 of of IN cord-010092-uftc8inx 5298 48 the the DT cord-010092-uftc8inx 5298 49 total total JJ cord-010092-uftc8inx 5298 50 female female JJ cord-010092-uftc8inx 5298 51 and and CC cord-010092-uftc8inx 5298 52 male male JJ cord-010092-uftc8inx 5298 53 repetitive repetitive JJ cord-010092-uftc8inx 5298 54 donors donor NNS cord-010092-uftc8inx 5298 55 of of IN cord-010092-uftc8inx 5298 56 platelets platelet NNS cord-010092-uftc8inx 5298 57 by by IN cord-010092-uftc8inx 5298 58 apheresis apheresis NN cord-010092-uftc8inx 5298 59 using use VBG cord-010092-uftc8inx 5298 60 Trima Trima NNP cord-010092-uftc8inx 5298 61 Accel Accel NNP cord-010092-uftc8inx 5299 1 â â LS cord-010092-uftc8inx 5299 2 Terumo Terumo NNP cord-010092-uftc8inx 5299 3 - - HYPH cord-010092-uftc8inx 5299 4 BCT BCT NNP cord-010092-uftc8inx 5299 5 and and CC cord-010092-uftc8inx 5299 6 Amicus Amicus NNP cord-010092-uftc8inx 5299 7 TM TM NNP cord-010092-uftc8inx 5299 8 Fresenius Fresenius NNP cord-010092-uftc8inx 5299 9 - - HYPH cord-010092-uftc8inx 5299 10 Kabi Kabi NNP cord-010092-uftc8inx 5299 11 . . . cord-010092-uftc8inx 5300 1 The the DT cord-010092-uftc8inx 5300 2 difference difference NN cord-010092-uftc8inx 5300 3 in in IN cord-010092-uftc8inx 5300 4 the the DT cord-010092-uftc8inx 5300 5 concentration concentration NN cord-010092-uftc8inx 5300 6 of of IN cord-010092-uftc8inx 5300 7 serum serum NN cord-010092-uftc8inx 5300 8 ferritin ferritin NN cord-010092-uftc8inx 5300 9 between between IN cord-010092-uftc8inx 5300 10 the the DT cord-010092-uftc8inx 5300 11 last last JJ cord-010092-uftc8inx 5300 12 and and CC cord-010092-uftc8inx 5300 13 first first JJ cord-010092-uftc8inx 5300 14 donation donation NN cord-010092-uftc8inx 5300 15 was be VBD cord-010092-uftc8inx 5300 16 established establish VBN cord-010092-uftc8inx 5300 17 , , , cord-010092-uftc8inx 5300 18 as as RB cord-010092-uftc8inx 5300 19 well well RB cord-010092-uftc8inx 5300 20 as as IN cord-010092-uftc8inx 5300 21 the the DT cord-010092-uftc8inx 5300 22 change change NN cord-010092-uftc8inx 5300 23 in in IN cord-010092-uftc8inx 5300 24 the the DT cord-010092-uftc8inx 5300 25 predonation predonation NN cord-010092-uftc8inx 5300 26 platelet platelet NN cord-010092-uftc8inx 5300 27 count count NN cord-010092-uftc8inx 5300 28 between between IN cord-010092-uftc8inx 5300 29 the the DT cord-010092-uftc8inx 5300 30 last last JJ cord-010092-uftc8inx 5300 31 and and CC cord-010092-uftc8inx 5300 32 first first JJ cord-010092-uftc8inx 5300 33 event event NN cord-010092-uftc8inx 5300 34 . . . cord-010092-uftc8inx 5301 1 Results result NNS cord-010092-uftc8inx 5301 2 : : : cord-010092-uftc8inx 5302 1 In in IN cord-010092-uftc8inx 5302 2 the the DT cord-010092-uftc8inx 5302 3 study study NN cord-010092-uftc8inx 5302 4 population population NN cord-010092-uftc8inx 5302 5 , , , cord-010092-uftc8inx 5302 6 43.8 43.8 CD cord-010092-uftc8inx 5302 7 % % NN cord-010092-uftc8inx 5302 8 of of IN cord-010092-uftc8inx 5302 9 women woman NNS cord-010092-uftc8inx 5302 10 and and CC cord-010092-uftc8inx 5302 11 40 40 CD cord-010092-uftc8inx 5302 12 % % NN cord-010092-uftc8inx 5302 13 of of IN cord-010092-uftc8inx 5302 14 men man NNS cord-010092-uftc8inx 5302 15 performed perform VBD cord-010092-uftc8inx 5302 16 repetitive repetitive JJ cord-010092-uftc8inx 5302 17 donations donation NNS cord-010092-uftc8inx 5302 18 of of IN cord-010092-uftc8inx 5302 19 platelets platelet NNS cord-010092-uftc8inx 5302 20 by by IN cord-010092-uftc8inx 5302 21 apheresis apheresis NN cord-010092-uftc8inx 5302 22 with with IN cord-010092-uftc8inx 5302 23 an an DT cord-010092-uftc8inx 5302 24 interval interval NN cord-010092-uftc8inx 5302 25 of of IN cord-010092-uftc8inx 5302 26 less less JJR cord-010092-uftc8inx 5302 27 than than IN cord-010092-uftc8inx 5302 28 three three CD cord-010092-uftc8inx 5302 29 months month NNS cord-010092-uftc8inx 5302 30 . . . cord-010092-uftc8inx 5303 1 The the DT cord-010092-uftc8inx 5303 2 change change NN cord-010092-uftc8inx 5303 3 in in IN cord-010092-uftc8inx 5303 4 ferritin ferritin NN cord-010092-uftc8inx 5303 5 concentration concentration NN cord-010092-uftc8inx 5303 6 was be VBD cord-010092-uftc8inx 5303 7 evaluated evaluate VBN cord-010092-uftc8inx 5303 8 according accord VBG cord-010092-uftc8inx 5303 9 to to IN cord-010092-uftc8inx 5303 10 the the DT cord-010092-uftc8inx 5303 11 interval interval NN cord-010092-uftc8inx 5303 12 between between IN cord-010092-uftc8inx 5303 13 donations donation NNS cord-010092-uftc8inx 5303 14 . . . cord-010092-uftc8inx 5304 1 In in IN cord-010092-uftc8inx 5304 2 women woman NNS cord-010092-uftc8inx 5304 3 ferritin ferritin NN cord-010092-uftc8inx 5304 4 delta delta NNP cord-010092-uftc8inx 5304 5 was be VBD cord-010092-uftc8inx 5304 6 À38.4 à38.4 CD cord-010092-uftc8inx 5304 7 AE AE NNP cord-010092-uftc8inx 5304 8 52.2 52.2 CD cord-010092-uftc8inx 5304 9 ng ng NNP cord-010092-uftc8inx 5304 10 / / SYM cord-010092-uftc8inx 5304 11 ml ml XX cord-010092-uftc8inx 5304 12 when when WRB cord-010092-uftc8inx 5304 13 the the DT cord-010092-uftc8inx 5304 14 donations donation NNS cord-010092-uftc8inx 5304 15 had have VBD cord-010092-uftc8inx 5304 16 an an DT cord-010092-uftc8inx 5304 17 interval interval NN cord-010092-uftc8inx 5304 18 less less JJR cord-010092-uftc8inx 5304 19 than than IN cord-010092-uftc8inx 5304 20 three three CD cord-010092-uftc8inx 5304 21 months month NNS cord-010092-uftc8inx 5304 22 , , , cord-010092-uftc8inx 5304 23 vs vs IN cord-010092-uftc8inx 5304 24 3.3 3.3 CD cord-010092-uftc8inx 5304 25 AE AE NNP cord-010092-uftc8inx 5304 26 13.0 13.0 CD cord-010092-uftc8inx 5304 27 ng ng NN cord-010092-uftc8inx 5304 28 / / SYM cord-010092-uftc8inx 5304 29 ml ml XX cord-010092-uftc8inx 5304 30 when when WRB cord-010092-uftc8inx 5304 31 the the DT cord-010092-uftc8inx 5304 32 time time NN cord-010092-uftc8inx 5304 33 between between IN cord-010092-uftc8inx 5304 34 donations donation NNS cord-010092-uftc8inx 5304 35 was be VBD cord-010092-uftc8inx 5304 36 higher high JJR cord-010092-uftc8inx 5304 37 ( ( -LRB- cord-010092-uftc8inx 5304 38 P p NN cord-010092-uftc8inx 5304 39 = = SYM cord-010092-uftc8inx 5304 40 0.046 0.046 CD cord-010092-uftc8inx 5304 41 ) ) -RRB- cord-010092-uftc8inx 5304 42 . . . cord-010092-uftc8inx 5305 1 In in IN cord-010092-uftc8inx 5305 2 men man NNS cord-010092-uftc8inx 5305 3 the the DT cord-010092-uftc8inx 5305 4 change change NN cord-010092-uftc8inx 5305 5 in in IN cord-010092-uftc8inx 5305 6 the the DT cord-010092-uftc8inx 5305 7 ferritin ferritin NN cord-010092-uftc8inx 5305 8 levels level NNS cord-010092-uftc8inx 5305 9 was be VBD cord-010092-uftc8inx 5305 10 À38.5 à38.5 JJ cord-010092-uftc8inx 5305 11 AE AE NNP cord-010092-uftc8inx 5305 12 61.2 61.2 CD cord-010092-uftc8inx 5305 13 ng ng NNP cord-010092-uftc8inx 5305 14 / / SYM cord-010092-uftc8inx 5305 15 ml ml XX cord-010092-uftc8inx 5305 16 with with IN cord-010092-uftc8inx 5305 17 donation donation NN cord-010092-uftc8inx 5305 18 times time NNS cord-010092-uftc8inx 5305 19 less less JJR cord-010092-uftc8inx 5305 20 than than IN cord-010092-uftc8inx 5305 21 three three CD cord-010092-uftc8inx 5305 22 months month NNS cord-010092-uftc8inx 5305 23 vs vs IN cord-010092-uftc8inx 5305 24 © © NN cord-010092-uftc8inx 5305 25 2019 2019 CD cord-010092-uftc8inx 5306 1 The the DT cord-010092-uftc8inx 5306 2 Authors author NNS cord-010092-uftc8inx 5306 3 Vox Vox NNP cord-010092-uftc8inx 5306 4 Sanguinis Sanguinis NNP cord-010092-uftc8inx 5306 5 © © NN cord-010092-uftc8inx 5307 1 2019 2019 CD cord-010092-uftc8inx 5307 2 International International NNP cord-010092-uftc8inx 5307 3 Society Society NNP cord-010092-uftc8inx 5307 4 of of IN cord-010092-uftc8inx 5307 5 Blood Blood NNP cord-010092-uftc8inx 5307 6 Transfusion Transfusion NNP cord-010092-uftc8inx 5307 7 Vox Vox NNP cord-010092-uftc8inx 5307 8 Sanguinis Sanguinis NNP cord-010092-uftc8inx 5307 9 ( ( -LRB- cord-010092-uftc8inx 5307 10 2019 2019 CD cord-010092-uftc8inx 5307 11 ) ) -RRB- cord-010092-uftc8inx 5307 12 114 114 CD cord-010092-uftc8inx 5308 1 ( ( -LRB- cord-010092-uftc8inx 5308 2 Suppl Suppl NNP cord-010092-uftc8inx 5308 3 . . . cord-010092-uftc8inx 5309 1 1 1 LS cord-010092-uftc8inx 5309 2 ) ) -RRB- cord-010092-uftc8inx 5309 3 , , , cord-010092-uftc8inx 5309 4 5 5 CD cord-010092-uftc8inx 5309 5 - - SYM cord-010092-uftc8inx 5309 6 240 240 CD cord-010092-uftc8inx 5309 7 À3.3 À3.3 NNP cord-010092-uftc8inx 5309 8 AE AE NNP cord-010092-uftc8inx 5309 9 38.9 38.9 CD cord-010092-uftc8inx 5309 10 ng ng NN cord-010092-uftc8inx 5309 11 / / SYM cord-010092-uftc8inx 5309 12 ml ml XX cord-010092-uftc8inx 5309 13 with with IN cord-010092-uftc8inx 5309 14 prolonged prolonged JJ cord-010092-uftc8inx 5309 15 donation donation NN cord-010092-uftc8inx 5309 16 times time NNS cord-010092-uftc8inx 5309 17 ( ( -LRB- cord-010092-uftc8inx 5309 18 P p NN cord-010092-uftc8inx 5309 19 = = SYM cord-010092-uftc8inx 5309 20 0.042 0.042 CD cord-010092-uftc8inx 5309 21 ) ) -RRB- cord-010092-uftc8inx 5309 22 . . . cord-010092-uftc8inx 5310 1 In in IN cord-010092-uftc8inx 5310 2 women woman NNS cord-010092-uftc8inx 5310 3 , , , cord-010092-uftc8inx 5310 4 the the DT cord-010092-uftc8inx 5310 5 change change NN cord-010092-uftc8inx 5310 6 in in IN cord-010092-uftc8inx 5310 7 platelet platelet NN cord-010092-uftc8inx 5310 8 count count NN cord-010092-uftc8inx 5310 9 was be VBD cord-010092-uftc8inx 5310 10 À2 À2 NNP cord-010092-uftc8inx 5310 11 AE AE NNP cord-010092-uftc8inx 5310 12 46.2 46.2 CD cord-010092-uftc8inx 5310 13 9 9 CD cord-010092-uftc8inx 5310 14 10 10 CD cord-010092-uftc8inx 5310 15 3 3 CD cord-010092-uftc8inx 5311 1 /ul /ul NFP cord-010092-uftc8inx 5311 2 , , , cord-010092-uftc8inx 5311 3 when when WRB cord-010092-uftc8inx 5311 4 the the DT cord-010092-uftc8inx 5311 5 donations donation NNS cord-010092-uftc8inx 5311 6 had have VBD cord-010092-uftc8inx 5311 7 an an DT cord-010092-uftc8inx 5311 8 interval interval NN cord-010092-uftc8inx 5311 9 less less JJR cord-010092-uftc8inx 5311 10 than than IN cord-010092-uftc8inx 5311 11 three three CD cord-010092-uftc8inx 5311 12 months month NNS cord-010092-uftc8inx 5311 13 vs vs IN cord-010092-uftc8inx 5311 14 À22 À22 NNP cord-010092-uftc8inx 5311 15 AE AE NNP cord-010092-uftc8inx 5311 16 45.3 45.3 CD cord-010092-uftc8inx 5312 1 9 9 CD cord-010092-uftc8inx 5312 2 10 10 CD cord-010092-uftc8inx 5312 3 3 3 CD cord-010092-uftc8inx 5312 4 /ul /ul . cord-010092-uftc8inx 5313 1 when when WRB cord-010092-uftc8inx 5313 2 the the DT cord-010092-uftc8inx 5313 3 time time NN cord-010092-uftc8inx 5313 4 between between IN cord-010092-uftc8inx 5313 5 donations donation NNS cord-010092-uftc8inx 5313 6 was be VBD cord-010092-uftc8inx 5313 7 greater great JJR cord-010092-uftc8inx 5313 8 ( ( -LRB- cord-010092-uftc8inx 5313 9 P p NN cord-010092-uftc8inx 5313 10 = = SYM cord-010092-uftc8inx 5313 11 0.43 0.43 CD cord-010092-uftc8inx 5313 12 ) ) -RRB- cord-010092-uftc8inx 5313 13 . . . cord-010092-uftc8inx 5314 1 In in IN cord-010092-uftc8inx 5314 2 men man NNS cord-010092-uftc8inx 5314 3 , , , cord-010092-uftc8inx 5314 4 the the DT cord-010092-uftc8inx 5314 5 delta delta NN cord-010092-uftc8inx 5314 6 of of IN cord-010092-uftc8inx 5314 7 the the DT cord-010092-uftc8inx 5314 8 platelet platelet NN cord-010092-uftc8inx 5314 9 count count NN cord-010092-uftc8inx 5314 10 was be VBD cord-010092-uftc8inx 5314 11 À12 À12 NNP cord-010092-uftc8inx 5314 12 AE AE NNP cord-010092-uftc8inx 5315 1 37.0 37.0 CD cord-010092-uftc8inx 5315 2 9 9 CD cord-010092-uftc8inx 5315 3 10 10 CD cord-010092-uftc8inx 5315 4 3 3 CD cord-010092-uftc8inx 5315 5 /ul /ul . cord-010092-uftc8inx 5316 1 in in IN cord-010092-uftc8inx 5316 2 donation donation NN cord-010092-uftc8inx 5316 3 times time NNS cord-010092-uftc8inx 5316 4 less less JJR cord-010092-uftc8inx 5316 5 than than IN cord-010092-uftc8inx 5316 6 three three CD cord-010092-uftc8inx 5316 7 months month NNS cord-010092-uftc8inx 5316 8 vs vs IN cord-010092-uftc8inx 5316 9 À13 À13 NNP cord-010092-uftc8inx 5316 10 AE AE NNP cord-010092-uftc8inx 5316 11 26.6 26.6 CD cord-010092-uftc8inx 5316 12 with with IN cord-010092-uftc8inx 5316 13 higher high JJR cord-010092-uftc8inx 5316 14 donation donation NN cord-010092-uftc8inx 5316 15 times time NNS cord-010092-uftc8inx 5316 16 ( ( -LRB- cord-010092-uftc8inx 5316 17 P p NN cord-010092-uftc8inx 5316 18 = = SYM cord-010092-uftc8inx 5316 19 0.93 0.93 CD cord-010092-uftc8inx 5316 20 ) ) -RRB- cord-010092-uftc8inx 5316 21 . . . cord-010092-uftc8inx 5317 1 No no DT cord-010092-uftc8inx 5317 2 correlation correlation NN cord-010092-uftc8inx 5317 3 was be VBD cord-010092-uftc8inx 5317 4 found find VBN cord-010092-uftc8inx 5317 5 between between IN cord-010092-uftc8inx 5317 6 the the DT cord-010092-uftc8inx 5317 7 concentrations concentration NNS cord-010092-uftc8inx 5317 8 of of IN cord-010092-uftc8inx 5317 9 serum serum NN cord-010092-uftc8inx 5317 10 ferritin ferritin NN cord-010092-uftc8inx 5317 11 and and CC cord-010092-uftc8inx 5317 12 the the DT cord-010092-uftc8inx 5317 13 platelet platelet NN cord-010092-uftc8inx 5317 14 count count NN cord-010092-uftc8inx 5317 15 ( ( -LRB- cord-010092-uftc8inx 5317 16 r r NN cord-010092-uftc8inx 5317 17 = = SYM cord-010092-uftc8inx 5317 18 0.05 0.05 CD cord-010092-uftc8inx 5317 19 , , , cord-010092-uftc8inx 5317 20 q q NN cord-010092-uftc8inx 5317 21 = = SYM cord-010092-uftc8inx 5317 22 0.75 0.75 CD cord-010092-uftc8inx 5317 23 for for IN cord-010092-uftc8inx 5317 24 males male NNS cord-010092-uftc8inx 5317 25 , , , cord-010092-uftc8inx 5317 26 and and CC cord-010092-uftc8inx 5317 27 r r NN cord-010092-uftc8inx 5317 28 = = SYM cord-010092-uftc8inx 5317 29 0.34 0.34 CD cord-010092-uftc8inx 5317 30 , , , cord-010092-uftc8inx 5317 31 q q NNP cord-010092-uftc8inx 5317 32 = = VBZ cord-010092-uftc8inx 5317 33 0.22 0.22 CD cord-010092-uftc8inx 5317 34 for for IN cord-010092-uftc8inx 5317 35 females female NNS cord-010092-uftc8inx 5317 36 ) ) -RRB- cord-010092-uftc8inx 5317 37 . . . cord-010092-uftc8inx 5318 1 Summary Summary NNP cord-010092-uftc8inx 5318 2 / / SYM cord-010092-uftc8inx 5318 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 5318 4 : : : cord-010092-uftc8inx 5319 1 The the DT cord-010092-uftc8inx 5319 2 data datum NNS cord-010092-uftc8inx 5319 3 obtained obtain VBD cord-010092-uftc8inx 5319 4 suggest suggest VBP cord-010092-uftc8inx 5319 5 that that IN cord-010092-uftc8inx 5319 6 repetitive repetitive JJ cord-010092-uftc8inx 5319 7 donation donation NN cord-010092-uftc8inx 5319 8 of of IN cord-010092-uftc8inx 5319 9 platelets platelet NNS cord-010092-uftc8inx 5319 10 by by IN cord-010092-uftc8inx 5319 11 apheresis apheresis NN cord-010092-uftc8inx 5319 12 with with IN cord-010092-uftc8inx 5319 13 intervals interval NNS cord-010092-uftc8inx 5319 14 between between IN cord-010092-uftc8inx 5319 15 donations donation NNS cord-010092-uftc8inx 5319 16 of of IN cord-010092-uftc8inx 5319 17 less less JJR cord-010092-uftc8inx 5319 18 than than IN cord-010092-uftc8inx 5319 19 three three CD cord-010092-uftc8inx 5319 20 months month NNS cord-010092-uftc8inx 5319 21 , , , cord-010092-uftc8inx 5319 22 significantly significantly RB cord-010092-uftc8inx 5319 23 reduce reduce VBP cord-010092-uftc8inx 5319 24 serum serum NN cord-010092-uftc8inx 5319 25 ferritin ferritin NN cord-010092-uftc8inx 5319 26 concentrations concentration NNS cord-010092-uftc8inx 5319 27 in in IN cord-010092-uftc8inx 5319 28 women woman NNS cord-010092-uftc8inx 5319 29 and and CC cord-010092-uftc8inx 5319 30 men man NNS cord-010092-uftc8inx 5319 31 , , , cord-010092-uftc8inx 5319 32 although although IN cord-010092-uftc8inx 5319 33 normal normal JJ cord-010092-uftc8inx 5319 34 levels level NNS cord-010092-uftc8inx 5319 35 were be VBD cord-010092-uftc8inx 5319 36 maintained maintain VBN cord-010092-uftc8inx 5319 37 in in IN cord-010092-uftc8inx 5319 38 both both DT cord-010092-uftc8inx 5319 39 groups group NNS cord-010092-uftc8inx 5319 40 . . . cord-010092-uftc8inx 5320 1 There there EX cord-010092-uftc8inx 5320 2 was be VBD cord-010092-uftc8inx 5320 3 no no DT cord-010092-uftc8inx 5320 4 correlation correlation NN cord-010092-uftc8inx 5320 5 with with IN cord-010092-uftc8inx 5320 6 platelet platelet NN cord-010092-uftc8inx 5320 7 count count NN cord-010092-uftc8inx 5320 8 . . . cord-010092-uftc8inx 5321 1 Therefore therefore RB cord-010092-uftc8inx 5321 2 , , , cord-010092-uftc8inx 5321 3 it -PRON- PRP cord-010092-uftc8inx 5321 4 is be VBZ cord-010092-uftc8inx 5321 5 proposed propose VBN cord-010092-uftc8inx 5321 6 to to TO cord-010092-uftc8inx 5321 7 develop develop VB cord-010092-uftc8inx 5321 8 prospective prospective JJ cord-010092-uftc8inx 5321 9 studies study NNS cord-010092-uftc8inx 5321 10 to to TO cord-010092-uftc8inx 5321 11 establish establish VB cord-010092-uftc8inx 5321 12 the the DT cord-010092-uftc8inx 5321 13 minimum minimum JJ cord-010092-uftc8inx 5321 14 time time NN cord-010092-uftc8inx 5321 15 interval interval NN cord-010092-uftc8inx 5321 16 safety safety NN cord-010092-uftc8inx 5321 17 for for IN cord-010092-uftc8inx 5321 18 platelet platelet NN cord-010092-uftc8inx 5321 19 apheresis apheresis NN cord-010092-uftc8inx 5321 20 donor donor NN cord-010092-uftc8inx 5321 21 procedures procedure NNS cord-010092-uftc8inx 5321 22 . . . cord-010092-uftc8inx 5322 1 Background background NN cord-010092-uftc8inx 5322 2 : : : cord-010092-uftc8inx 5323 1 The the DT cord-010092-uftc8inx 5323 2 demand demand NN cord-010092-uftc8inx 5323 3 for for IN cord-010092-uftc8inx 5323 4 platelets platelet NNS cord-010092-uftc8inx 5323 5 concentrates concentrate VBZ cord-010092-uftc8inx 5323 6 is be VBZ cord-010092-uftc8inx 5323 7 increasing increase VBG cord-010092-uftc8inx 5323 8 continuously continuously RB cord-010092-uftc8inx 5323 9 and and CC cord-010092-uftc8inx 5323 10 becomes become VBZ cord-010092-uftc8inx 5323 11 a a DT cord-010092-uftc8inx 5323 12 challenge challenge NN cord-010092-uftc8inx 5323 13 for for IN cord-010092-uftc8inx 5323 14 the the DT cord-010092-uftc8inx 5323 15 blood blood NN cord-010092-uftc8inx 5323 16 establishments establishment NNS cord-010092-uftc8inx 5323 17 . . . cord-010092-uftc8inx 5324 1 Apheresis apheresis NN cord-010092-uftc8inx 5324 2 platelet platelet NN cord-010092-uftc8inx 5324 3 collections collection NNS cord-010092-uftc8inx 5324 4 may may MD cord-010092-uftc8inx 5324 5 be be VB cord-010092-uftc8inx 5324 6 a a DT cord-010092-uftc8inx 5324 7 solution solution NN cord-010092-uftc8inx 5324 8 for for IN cord-010092-uftc8inx 5324 9 this this DT cord-010092-uftc8inx 5324 10 challenge challenge NN cord-010092-uftc8inx 5324 11 . . . cord-010092-uftc8inx 5325 1 Improving improve VBG cord-010092-uftc8inx 5325 2 apheresis apheresis NN cord-010092-uftc8inx 5325 3 collection collection NN cord-010092-uftc8inx 5325 4 efficiency efficiency NN cord-010092-uftc8inx 5325 5 while while IN cord-010092-uftc8inx 5325 6 maintaining maintain VBG cord-010092-uftc8inx 5325 7 blood blood NN cord-010092-uftc8inx 5325 8 donor donor NN cord-010092-uftc8inx 5325 9 safety safety NN cord-010092-uftc8inx 5325 10 is be VBZ cord-010092-uftc8inx 5325 11 an an DT cord-010092-uftc8inx 5325 12 important important JJ cord-010092-uftc8inx 5325 13 goal goal NN cord-010092-uftc8inx 5325 14 for for IN cord-010092-uftc8inx 5325 15 the the DT cord-010092-uftc8inx 5325 16 Service Service NNP cord-010092-uftc8inx 5325 17 du du NNP cord-010092-uftc8inx 5325 18 Sang Sang NNP cord-010092-uftc8inx 5325 19 of of IN cord-010092-uftc8inx 5325 20 the the DT cord-010092-uftc8inx 5325 21 Belgian belgian JJ cord-010092-uftc8inx 5325 22 Red Red NNP cord-010092-uftc8inx 5325 23 Cross Cross NNP cord-010092-uftc8inx 5325 24 . . . cord-010092-uftc8inx 5326 1 Aims aim VBZ cord-010092-uftc8inx 5326 2 : : : cord-010092-uftc8inx 5326 3 Our -PRON- PRP$ cord-010092-uftc8inx 5326 4 establishment establishment NN cord-010092-uftc8inx 5326 5 evaluated evaluate VBD cord-010092-uftc8inx 5326 6 the the DT cord-010092-uftc8inx 5326 7 improvements improvement NNS cord-010092-uftc8inx 5326 8 of of IN cord-010092-uftc8inx 5326 9 the the DT cord-010092-uftc8inx 5326 10 Trima Trima NNP cord-010092-uftc8inx 5326 11 Accel Accel NNP cord-010092-uftc8inx 5326 12 Automated Automated NNP cord-010092-uftc8inx 5326 13 Blood Blood NNP cord-010092-uftc8inx 5326 14 Collection Collection NNP cord-010092-uftc8inx 5326 15 System System NNP cord-010092-uftc8inx 5326 16 Version Version NNP cord-010092-uftc8inx 5326 17 7 7 CD cord-010092-uftc8inx 5326 18 ( ( -LRB- cord-010092-uftc8inx 5326 19 TA7 TA7 NNP cord-010092-uftc8inx 5326 20 ) ) -RRB- cord-010092-uftc8inx 5326 21 by by IN cord-010092-uftc8inx 5326 22 comparing compare VBG cord-010092-uftc8inx 5326 23 its -PRON- PRP$ cord-010092-uftc8inx 5326 24 routine routine JJ cord-010092-uftc8inx 5326 25 performance performance NN cord-010092-uftc8inx 5326 26 with with IN cord-010092-uftc8inx 5326 27 that that DT cord-010092-uftc8inx 5326 28 of of IN cord-010092-uftc8inx 5326 29 the the DT cord-010092-uftc8inx 5326 30 previous previous JJ cord-010092-uftc8inx 5326 31 software software NN cord-010092-uftc8inx 5326 32 version version NN cord-010092-uftc8inx 5326 33 6.06 6.06 CD cord-010092-uftc8inx 5326 34 ( ( -LRB- cord-010092-uftc8inx 5326 35 TA6 TA6 NNP cord-010092-uftc8inx 5326 36 ) ) -RRB- cord-010092-uftc8inx 5326 37 . . . cord-010092-uftc8inx 5327 1 Methods method NNS cord-010092-uftc8inx 5327 2 : : : cord-010092-uftc8inx 5327 3 Prospective prospective JJ cord-010092-uftc8inx 5327 4 , , , cord-010092-uftc8inx 5327 5 multi multi JJ cord-010092-uftc8inx 5327 6 - - NN cord-010092-uftc8inx 5327 7 site site NN cord-010092-uftc8inx 5327 8 , , , cord-010092-uftc8inx 5327 9 controlled control VBN cord-010092-uftc8inx 5327 10 , , , cord-010092-uftc8inx 5327 11 non non JJ cord-010092-uftc8inx 5327 12 - - JJ cord-010092-uftc8inx 5327 13 randomized randomized JJ cord-010092-uftc8inx 5327 14 trial trial NN cord-010092-uftc8inx 5327 15 . . . cord-010092-uftc8inx 5328 1 Apheresis apheresis NN cord-010092-uftc8inx 5328 2 collections collection NNS cord-010092-uftc8inx 5328 3 were be VBD cord-010092-uftc8inx 5328 4 performed perform VBN cord-010092-uftc8inx 5328 5 in in IN cord-010092-uftc8inx 5328 6 three three CD cord-010092-uftc8inx 5328 7 SFS SFS NNP cord-010092-uftc8inx 5328 8 sites site NNS cord-010092-uftc8inx 5328 9 : : : cord-010092-uftc8inx 5328 10 Liege Liege NNP cord-010092-uftc8inx 5328 11 , , , cord-010092-uftc8inx 5328 12 Mons Mons NNP cord-010092-uftc8inx 5328 13 and and CC cord-010092-uftc8inx 5328 14 Namur Namur NNP cord-010092-uftc8inx 5328 15 using use VBG cord-010092-uftc8inx 5328 16 the the DT cord-010092-uftc8inx 5328 17 two two CD cord-010092-uftc8inx 5328 18 Trima Trima NNP cord-010092-uftc8inx 5328 19 software software NN cord-010092-uftc8inx 5328 20 versions version NNS cord-010092-uftc8inx 5328 21 TA6 TA6 NNP cord-010092-uftc8inx 5328 22 and and CC cord-010092-uftc8inx 5328 23 TA7 ta7 NN cord-010092-uftc8inx 5328 24 sequentially sequentially RB cord-010092-uftc8inx 5328 25 . . . cord-010092-uftc8inx 5329 1 Data datum NNS cord-010092-uftc8inx 5329 2 were be VBD cord-010092-uftc8inx 5329 3 collected collect VBN cord-010092-uftc8inx 5329 4 from from IN cord-010092-uftc8inx 5329 5 December December NNP cord-010092-uftc8inx 5329 6 2017 2017 CD cord-010092-uftc8inx 5329 7 to to IN cord-010092-uftc8inx 5329 8 April April NNP cord-010092-uftc8inx 5329 9 2018 2018 CD cord-010092-uftc8inx 5329 10 on on IN cord-010092-uftc8inx 5329 11 TA6 TA6 NNP cord-010092-uftc8inx 5329 12 and and CC cord-010092-uftc8inx 5329 13 from from IN cord-010092-uftc8inx 5329 14 June June NNP cord-010092-uftc8inx 5329 15 to to IN cord-010092-uftc8inx 5329 16 July July NNP cord-010092-uftc8inx 5329 17 2018 2018 CD cord-010092-uftc8inx 5329 18 on on IN cord-010092-uftc8inx 5329 19 TA7 TA7 NNP cord-010092-uftc8inx 5329 20 . . . cord-010092-uftc8inx 5330 1 Simple simple JJ cord-010092-uftc8inx 5330 2 and and CC cord-010092-uftc8inx 5330 3 double double JJ cord-010092-uftc8inx 5330 4 doses dose NNS cord-010092-uftc8inx 5330 5 of of IN cord-010092-uftc8inx 5330 6 platelets platelet NNS cord-010092-uftc8inx 5330 7 ( ( -LRB- cord-010092-uftc8inx 5330 8 respectively respectively RB cord-010092-uftc8inx 5330 9 5.0 5.0 CD cord-010092-uftc8inx 5330 10 9 9 CD cord-010092-uftc8inx 5330 11 10 10 CD cord-010092-uftc8inx 5330 12 11 11 CD cord-010092-uftc8inx 5330 13 , , , cord-010092-uftc8inx 5330 14 5.5 5.5 CD cord-010092-uftc8inx 5330 15 9 9 CD cord-010092-uftc8inx 5330 16 10 10 CD cord-010092-uftc8inx 5330 17 11 11 CD cord-010092-uftc8inx 5330 18 and and CC cord-010092-uftc8inx 5330 19 8.0 8.0 CD cord-010092-uftc8inx 5330 20 9 9 CD cord-010092-uftc8inx 5330 21 10 10 CD cord-010092-uftc8inx 5330 22 11 11 CD cord-010092-uftc8inx 5330 23 , , , cord-010092-uftc8inx 5330 24 9.0 9.0 CD cord-010092-uftc8inx 5330 25 9 9 CD cord-010092-uftc8inx 5330 26 10 10 CD cord-010092-uftc8inx 5330 27 11 11 CD cord-010092-uftc8inx 5330 28 ) ) -RRB- cord-010092-uftc8inx 5330 29 were be VBD cord-010092-uftc8inx 5330 30 collected collect VBN cord-010092-uftc8inx 5330 31 in in IN cord-010092-uftc8inx 5330 32 platelet platelet NN cord-010092-uftc8inx 5330 33 additive additive NN cord-010092-uftc8inx 5330 34 solution solution NN cord-010092-uftc8inx 5330 35 ( ( -LRB- cord-010092-uftc8inx 5330 36 SSP+ SSP+ NNP cord-010092-uftc8inx 5330 37 , , , cord-010092-uftc8inx 5330 38 MacoPharma MacoPharma NNP cord-010092-uftc8inx 5330 39 ) ) -RRB- cord-010092-uftc8inx 5330 40 with with IN cord-010092-uftc8inx 5330 41 concurrent concurrent JJ cord-010092-uftc8inx 5330 42 plasma plasma NN cord-010092-uftc8inx 5330 43 from from IN cord-010092-uftc8inx 5330 44 the the DT cord-010092-uftc8inx 5330 45 same same JJ cord-010092-uftc8inx 5330 46 cohort cohort NN cord-010092-uftc8inx 5330 47 of of IN cord-010092-uftc8inx 5330 48 donors donor NNS cord-010092-uftc8inx 5330 49 in in IN cord-010092-uftc8inx 5330 50 accordance accordance NN cord-010092-uftc8inx 5330 51 to to IN cord-010092-uftc8inx 5330 52 donor donor NN cord-010092-uftc8inx 5330 53 's 's POS cord-010092-uftc8inx 5330 54 eligibility eligibility NN cord-010092-uftc8inx 5330 55 and and CC cord-010092-uftc8inx 5330 56 preferences preference NNS cord-010092-uftc8inx 5330 57 . . . cord-010092-uftc8inx 5331 1 In in IN cord-010092-uftc8inx 5331 2 order order NN cord-010092-uftc8inx 5331 3 to to TO cord-010092-uftc8inx 5331 4 maintain maintain VB cord-010092-uftc8inx 5331 5 the the DT cord-010092-uftc8inx 5331 6 same same JJ cord-010092-uftc8inx 5331 7 final final JJ cord-010092-uftc8inx 5331 8 platelets platelet NNS cord-010092-uftc8inx 5331 9 content content NN cord-010092-uftc8inx 5331 10 in in IN cord-010092-uftc8inx 5331 11 Platelets platelet NNS cord-010092-uftc8inx 5331 12 Concentrates concentrate VBZ cord-010092-uftc8inx 5331 13 , , , cord-010092-uftc8inx 5331 14 the the DT cord-010092-uftc8inx 5331 15 Trima Trima NNP cord-010092-uftc8inx 5331 16 Accel Accel NNP cord-010092-uftc8inx 5331 17 's 's POS cord-010092-uftc8inx 5331 18 tool tool NN cord-010092-uftc8inx 5331 19 Yield yield NN cord-010092-uftc8inx 5331 20 Scaling Scaling NNP cord-010092-uftc8inx 5331 21 Factor Factor NNP cord-010092-uftc8inx 5331 22 ( ( -LRB- cord-010092-uftc8inx 5331 23 YSF YSF NNP cord-010092-uftc8inx 5331 24 ) ) -RRB- cord-010092-uftc8inx 5331 25 was be VBD cord-010092-uftc8inx 5331 26 subsequently subsequently RB cord-010092-uftc8inx 5331 27 adjusted adjust VBN cord-010092-uftc8inx 5331 28 from from IN cord-010092-uftc8inx 5331 29 1.06 1.06 CD cord-010092-uftc8inx 5331 30 ( ( -LRB- cord-010092-uftc8inx 5331 31 TA6 TA6 NNP cord-010092-uftc8inx 5331 32 ) ) -RRB- cord-010092-uftc8inx 5331 33 to to IN cord-010092-uftc8inx 5331 34 1 1 CD cord-010092-uftc8inx 5331 35 ( ( -LRB- cord-010092-uftc8inx 5331 36 TA7 TA7 NNP cord-010092-uftc8inx 5331 37 ) ) -RRB- cord-010092-uftc8inx 5331 38 . . . cord-010092-uftc8inx 5332 1 Platelet platelet NN cord-010092-uftc8inx 5332 2 yield yield NN cord-010092-uftc8inx 5332 3 , , , cord-010092-uftc8inx 5332 4 duration duration NN cord-010092-uftc8inx 5332 5 of of IN cord-010092-uftc8inx 5332 6 procedure procedure NN cord-010092-uftc8inx 5332 7 , , , cord-010092-uftc8inx 5332 8 number number NN cord-010092-uftc8inx 5332 9 of of IN cord-010092-uftc8inx 5332 10 alarms alarm NNS cord-010092-uftc8inx 5332 11 requiring require VBG cord-010092-uftc8inx 5332 12 operators operator NNS cord-010092-uftc8inx 5332 13 ' ' POS cord-010092-uftc8inx 5332 14 interventions intervention NNS cord-010092-uftc8inx 5332 15 were be VBD cord-010092-uftc8inx 5332 16 recorded record VBN cord-010092-uftc8inx 5332 17 and and CC cord-010092-uftc8inx 5332 18 evaluated evaluate VBN cord-010092-uftc8inx 5332 19 . . . cord-010092-uftc8inx 5333 1 Donor donor NN cord-010092-uftc8inx 5333 2 's 's POS cord-010092-uftc8inx 5333 3 hypocalcemia hypocalcemia NN cord-010092-uftc8inx 5333 4 was be VBD cord-010092-uftc8inx 5333 5 avoided avoid VBN cord-010092-uftc8inx 5333 6 by by IN cord-010092-uftc8inx 5333 7 giving give VBG cord-010092-uftc8inx 5333 8 preventively preventively RB cord-010092-uftc8inx 5333 9 oral oral JJ cord-010092-uftc8inx 5333 10 or or CC cord-010092-uftc8inx 5333 11 intravenous intravenous JJ cord-010092-uftc8inx 5333 12 calcium calcium NN cord-010092-uftc8inx 5333 13 which which WDT cord-010092-uftc8inx 5333 14 was be VBD cord-010092-uftc8inx 5333 15 documented document VBN cord-010092-uftc8inx 5333 16 by by IN cord-010092-uftc8inx 5333 17 the the DT cord-010092-uftc8inx 5333 18 operators operator NNS cord-010092-uftc8inx 5333 19 . . . cord-010092-uftc8inx 5334 1 Results result NNS cord-010092-uftc8inx 5334 2 : : : cord-010092-uftc8inx 5335 1 Five five CD cord-010092-uftc8inx 5335 2 hundred hundred CD cord-010092-uftc8inx 5335 3 ninety ninety CD cord-010092-uftc8inx 5335 4 ( ( -LRB- cord-010092-uftc8inx 5335 5 590 590 CD cord-010092-uftc8inx 5335 6 ) ) -RRB- cord-010092-uftc8inx 5335 7 collections collection NNS cord-010092-uftc8inx 5335 8 with with IN cord-010092-uftc8inx 5335 9 TA6 TA6 NNP cord-010092-uftc8inx 5335 10 and and CC cord-010092-uftc8inx 5335 11 607 607 CD cord-010092-uftc8inx 5335 12 with with IN cord-010092-uftc8inx 5335 13 TA7 TA7 NNP cord-010092-uftc8inx 5335 14 were be VBD cord-010092-uftc8inx 5335 15 recorded record VBN cord-010092-uftc8inx 5335 16 , , , cord-010092-uftc8inx 5335 17 with with IN cord-010092-uftc8inx 5335 18 92 92 CD cord-010092-uftc8inx 5335 19 % % NN cord-010092-uftc8inx 5335 20 and and CC cord-010092-uftc8inx 5335 21 95 95 CD cord-010092-uftc8inx 5335 22 % % NN cord-010092-uftc8inx 5335 23 complete complete JJ cord-010092-uftc8inx 5335 24 procedures procedure NNS cord-010092-uftc8inx 5335 25 respectively respectively RB cord-010092-uftc8inx 5335 26 . . . cord-010092-uftc8inx 5336 1 Mean mean JJ cord-010092-uftc8inx 5336 2 duration duration NN cord-010092-uftc8inx 5336 3 of of IN cord-010092-uftc8inx 5336 4 procedures procedure NNS cord-010092-uftc8inx 5336 5 was be VBD cord-010092-uftc8inx 5336 6 70 70 CD cord-010092-uftc8inx 5336 7 min min NN cord-010092-uftc8inx 5336 8 on on IN cord-010092-uftc8inx 5336 9 TA6 TA6 NNP cord-010092-uftc8inx 5336 10 against against IN cord-010092-uftc8inx 5336 11 72 72 CD cord-010092-uftc8inx 5336 12 min min NN cord-010092-uftc8inx 5336 13 on on IN cord-010092-uftc8inx 5336 14 TA7 ta7 NN cord-010092-uftc8inx 5336 15 , , , cord-010092-uftc8inx 5336 16 P p NN cord-010092-uftc8inx 5336 17 < < XX cord-010092-uftc8inx 5336 18 0.05 0.05 CD cord-010092-uftc8inx 5336 19 . . . cord-010092-uftc8inx 5337 1 The the DT cord-010092-uftc8inx 5337 2 mean mean JJ cord-010092-uftc8inx 5337 3 alerts alert VBZ cord-010092-uftc8inx 5337 4 number number NN cord-010092-uftc8inx 5337 5 per per IN cord-010092-uftc8inx 5337 6 procedure procedure NN cord-010092-uftc8inx 5337 7 on on IN cord-010092-uftc8inx 5337 8 TA6 TA6 NNP cord-010092-uftc8inx 5337 9 was be VBD cord-010092-uftc8inx 5337 10 4.1 4.1 CD cord-010092-uftc8inx 5337 11 against against IN cord-010092-uftc8inx 5337 12 0.5 0.5 CD cord-010092-uftc8inx 5337 13 on on IN cord-010092-uftc8inx 5337 14 TA7 ta7 NN cord-010092-uftc8inx 5337 15 , , , cord-010092-uftc8inx 5337 16 P p NN cord-010092-uftc8inx 5337 17 < < XX cord-010092-uftc8inx 5337 18 0.05 0.05 CD cord-010092-uftc8inx 5337 19 whereas whereas IN cord-010092-uftc8inx 5337 20 the the DT cord-010092-uftc8inx 5337 21 maximum maximum JJ cord-010092-uftc8inx 5337 22 alerts alert NNS cord-010092-uftc8inx 5337 23 number number NN cord-010092-uftc8inx 5337 24 per per IN cord-010092-uftc8inx 5337 25 procedure procedure NN cord-010092-uftc8inx 5337 26 was be VBD cord-010092-uftc8inx 5337 27 57 57 CD cord-010092-uftc8inx 5337 28 and and CC cord-010092-uftc8inx 5337 29 12 12 CD cord-010092-uftc8inx 5337 30 respectively respectively RB cord-010092-uftc8inx 5337 31 . . . cord-010092-uftc8inx 5338 1 On on IN cord-010092-uftc8inx 5338 2 TA7 TA7 NNP cord-010092-uftc8inx 5338 3 , , , cord-010092-uftc8inx 5338 4 76 76 CD cord-010092-uftc8inx 5338 5 % % NN cord-010092-uftc8inx 5338 6 procedures procedure NNS cord-010092-uftc8inx 5338 7 did do VBD cord-010092-uftc8inx 5338 8 not not RB cord-010092-uftc8inx 5338 9 require require VB cord-010092-uftc8inx 5338 10 operator operator NN cord-010092-uftc8inx 5338 11 's 's POS cord-010092-uftc8inx 5338 12 intervention intervention NN cord-010092-uftc8inx 5338 13 against against IN cord-010092-uftc8inx 5338 14 40 40 CD cord-010092-uftc8inx 5338 15 % % NN cord-010092-uftc8inx 5338 16 on on IN cord-010092-uftc8inx 5338 17 TA6 TA6 NNP cord-010092-uftc8inx 5338 18 , , , cord-010092-uftc8inx 5338 19 . . . cord-010092-uftc8inx 5339 1 With with IN cord-010092-uftc8inx 5339 2 TA7 TA7 NNP cord-010092-uftc8inx 5339 3 the the DT cord-010092-uftc8inx 5339 4 inlet inlet NN cord-010092-uftc8inx 5339 5 flowrate flowrate NN cord-010092-uftc8inx 5339 6 was be VBD cord-010092-uftc8inx 5339 7 automatically automatically RB cord-010092-uftc8inx 5339 8 adjusted adjust VBN cord-010092-uftc8inx 5339 9 in in IN cord-010092-uftc8inx 5339 10 97.2 97.2 CD cord-010092-uftc8inx 5339 11 % % NN cord-010092-uftc8inx 5339 12 procedures procedure NNS cord-010092-uftc8inx 5339 13 . . . cord-010092-uftc8inx 5340 1 The the DT cord-010092-uftc8inx 5340 2 inlet inlet NN cord-010092-uftc8inx 5340 3 flowrate flowrate NN cord-010092-uftc8inx 5340 4 was be VBD cord-010092-uftc8inx 5340 5 increased increase VBN cord-010092-uftc8inx 5340 6 in in IN cord-010092-uftc8inx 5340 7 response response NN cord-010092-uftc8inx 5340 8 to to TO cord-010092-uftc8inx 5340 9 access access VB cord-010092-uftc8inx 5340 10 pressure pressure NN cord-010092-uftc8inx 5340 11 in in IN cord-010092-uftc8inx 5340 12 45.6 45.6 CD cord-010092-uftc8inx 5340 13 % % NN cord-010092-uftc8inx 5340 14 of of IN cord-010092-uftc8inx 5340 15 procedures procedure NNS cord-010092-uftc8inx 5340 16 , , , cord-010092-uftc8inx 5340 17 for for IN cord-010092-uftc8inx 5340 18 3 3 CD cord-010092-uftc8inx 5340 19 % % NN cord-010092-uftc8inx 5340 20 of of IN cord-010092-uftc8inx 5340 21 the the DT cord-010092-uftc8inx 5340 22 procedures procedure NNS cord-010092-uftc8inx 5340 23 the the DT cord-010092-uftc8inx 5340 24 inlet inlet NN cord-010092-uftc8inx 5340 25 flowrate flowrate NN cord-010092-uftc8inx 5340 26 was be VBD cord-010092-uftc8inx 5340 27 decreased decrease VBN cord-010092-uftc8inx 5340 28 and and CC cord-010092-uftc8inx 5340 29 for for IN cord-010092-uftc8inx 5340 30 48.6 48.6 CD cord-010092-uftc8inx 5340 31 % % NN cord-010092-uftc8inx 5340 32 of of IN cord-010092-uftc8inx 5340 33 the the DT cord-010092-uftc8inx 5340 34 procedures procedure NNS cord-010092-uftc8inx 5340 35 the the DT cord-010092-uftc8inx 5340 36 inlet inlet NN cord-010092-uftc8inx 5340 37 flowrate flowrate NN cord-010092-uftc8inx 5340 38 was be VBD cord-010092-uftc8inx 5340 39 increase increase NN cord-010092-uftc8inx 5340 40 and and CC cord-010092-uftc8inx 5340 41 decreased decrease VBD cord-010092-uftc8inx 5340 42 on on IN cord-010092-uftc8inx 5340 43 the the DT cord-010092-uftc8inx 5340 44 same same JJ cord-010092-uftc8inx 5340 45 procedure procedure NN cord-010092-uftc8inx 5340 46 by by IN cord-010092-uftc8inx 5340 47 the the DT cord-010092-uftc8inx 5340 48 TA7 TA7 NNP cord-010092-uftc8inx 5340 49 autoflow autoflow NN cord-010092-uftc8inx 5340 50 system system NN cord-010092-uftc8inx 5340 51 . . . cord-010092-uftc8inx 5341 1 Summary Summary NNP cord-010092-uftc8inx 5341 2 / / SYM cord-010092-uftc8inx 5341 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 5341 4 : : : cord-010092-uftc8inx 5342 1 TA7 TA7 NNP cord-010092-uftc8inx 5342 2 with with IN cord-010092-uftc8inx 5342 3 its -PRON- PRP$ cord-010092-uftc8inx 5342 4 Autoflow Autoflow NNP cord-010092-uftc8inx 5342 5 function function NN cord-010092-uftc8inx 5342 6 improves improve VBZ cord-010092-uftc8inx 5342 7 apheresis apheresis NN cord-010092-uftc8inx 5342 8 donors donor NNS cord-010092-uftc8inx 5342 9 experience experience NN cord-010092-uftc8inx 5342 10 while while IN cord-010092-uftc8inx 5342 11 decreasing decrease VBG cord-010092-uftc8inx 5342 12 operator operator NN cord-010092-uftc8inx 5342 13 ' ' '' cord-010092-uftc8inx 5342 14 interventions intervention NNS cord-010092-uftc8inx 5342 15 through through IN cord-010092-uftc8inx 5342 16 a a DT cord-010092-uftc8inx 5342 17 significant significant JJ cord-010092-uftc8inx 5342 18 reduction reduction NN cord-010092-uftc8inx 5342 19 of of IN cord-010092-uftc8inx 5342 20 access access NN cord-010092-uftc8inx 5342 21 draw draw NN cord-010092-uftc8inx 5342 22 alerts alert NNS cord-010092-uftc8inx 5342 23 . . . cord-010092-uftc8inx 5343 1 As as IN cord-010092-uftc8inx 5343 2 expected expect VBN cord-010092-uftc8inx 5343 3 from from IN cord-010092-uftc8inx 5343 4 the the DT cord-010092-uftc8inx 5343 5 Trima Trima NNP cord-010092-uftc8inx 5343 6 Accel Accel NNP cord-010092-uftc8inx 5343 7 platform platform NN cord-010092-uftc8inx 5343 8 , , , cord-010092-uftc8inx 5343 9 post post JJ cord-010092-uftc8inx 5343 10 - - JJ cord-010092-uftc8inx 5343 11 donation donation JJ cord-010092-uftc8inx 5343 12 safety safety NN cord-010092-uftc8inx 5343 13 remains remain VBZ cord-010092-uftc8inx 5343 14 high high JJ cord-010092-uftc8inx 5343 15 . . . cord-010092-uftc8inx 5344 1 A a DT cord-010092-uftc8inx 5344 2 weak weak JJ cord-010092-uftc8inx 5344 3 increase increase NN cord-010092-uftc8inx 5344 4 in in IN cord-010092-uftc8inx 5344 5 procedure procedure NN cord-010092-uftc8inx 5344 6 duration duration NN cord-010092-uftc8inx 5344 7 was be VBD cord-010092-uftc8inx 5344 8 observed observe VBN cord-010092-uftc8inx 5344 9 for for IN cord-010092-uftc8inx 5344 10 the the DT cord-010092-uftc8inx 5344 11 same same JJ cord-010092-uftc8inx 5344 12 platelet platelet NN cord-010092-uftc8inx 5344 13 yield yield NN cord-010092-uftc8inx 5344 14 which which WDT cord-010092-uftc8inx 5344 15 may may MD cord-010092-uftc8inx 5344 16 be be VB cord-010092-uftc8inx 5344 17 resolved resolve VBN cord-010092-uftc8inx 5344 18 with with IN cord-010092-uftc8inx 5344 19 further further JJ cord-010092-uftc8inx 5344 20 adjustments adjustment NNS cord-010092-uftc8inx 5344 21 . . . cord-010092-uftc8inx 5345 1 Background background NN cord-010092-uftc8inx 5345 2 : : : cord-010092-uftc8inx 5346 1 Trima Trima NNP cord-010092-uftc8inx 5346 2 Accel Accel NNP cord-010092-uftc8inx 5346 3 system system NN cord-010092-uftc8inx 5346 4 is be VBZ cord-010092-uftc8inx 5346 5 an an DT cord-010092-uftc8inx 5346 6 apheresis apheresis NN cord-010092-uftc8inx 5346 7 platform platform NN cord-010092-uftc8inx 5346 8 relying rely VBG cord-010092-uftc8inx 5346 9 on on IN cord-010092-uftc8inx 5346 10 continuous continuous JJ cord-010092-uftc8inx 5346 11 flow flow NN cord-010092-uftc8inx 5346 12 centrifugation centrifugation NN cord-010092-uftc8inx 5346 13 to to TO cord-010092-uftc8inx 5346 14 collect collect VB cord-010092-uftc8inx 5346 15 from from IN cord-010092-uftc8inx 5346 16 a a DT cord-010092-uftc8inx 5346 17 donor donor NN cord-010092-uftc8inx 5346 18 platelets platelet NNS cord-010092-uftc8inx 5346 19 , , , cord-010092-uftc8inx 5346 20 plasma plasma NN cord-010092-uftc8inx 5346 21 or or CC cord-010092-uftc8inx 5346 22 RBCs rbc NNS cord-010092-uftc8inx 5346 23 based base VBN cord-010092-uftc8inx 5346 24 on on IN cord-010092-uftc8inx 5346 25 donor donor NN cord-010092-uftc8inx 5346 26 qualification qualification NN cord-010092-uftc8inx 5346 27 . . . cord-010092-uftc8inx 5347 1 The the DT cord-010092-uftc8inx 5347 2 latest late JJS cord-010092-uftc8inx 5347 3 software software NN cord-010092-uftc8inx 5347 4 version version NN cord-010092-uftc8inx 5347 5 -Trima -Trima . cord-010092-uftc8inx 5347 6 Accel Accel NNP cord-010092-uftc8inx 5347 7 7 7 CD cord-010092-uftc8inx 5347 8 ( ( -LRB- cord-010092-uftc8inx 5347 9 TA7 TA7 NNP cord-010092-uftc8inx 5347 10 ) ) -RRB- cord-010092-uftc8inx 5347 11 introduced introduce VBD cord-010092-uftc8inx 5347 12 the the DT cord-010092-uftc8inx 5347 13 AutoFlow AutoFlow NNP cord-010092-uftc8inx 5347 14 feature feature NN cord-010092-uftc8inx 5347 15 which which WDT cord-010092-uftc8inx 5347 16 allows allow VBZ cord-010092-uftc8inx 5347 17 for for IN cord-010092-uftc8inx 5347 18 automated automate VBN cord-010092-uftc8inx 5347 19 flow flow NN cord-010092-uftc8inx 5347 20 rate rate NN cord-010092-uftc8inx 5347 21 adjustments adjustment NNS cord-010092-uftc8inx 5347 22 . . . cord-010092-uftc8inx 5348 1 Moreover moreover RB cord-010092-uftc8inx 5348 2 , , , cord-010092-uftc8inx 5348 3 TA7 TA7 NNP cord-010092-uftc8inx 5348 4 leverages leverage VBZ cord-010092-uftc8inx 5348 5 the the DT cord-010092-uftc8inx 5348 6 mobilization mobilization NN cord-010092-uftc8inx 5348 7 capacity capacity NN cord-010092-uftc8inx 5348 8 of of IN cord-010092-uftc8inx 5348 9 the the DT cord-010092-uftc8inx 5348 10 spleen spleen NN cord-010092-uftc8inx 5348 11 increasing increase VBG cord-010092-uftc8inx 5348 12 potential potential JJ cord-010092-uftc8inx 5348 13 platelet platelet NN cord-010092-uftc8inx 5348 14 productivity productivity NN cord-010092-uftc8inx 5348 15 while while IN cord-010092-uftc8inx 5348 16 maintaining maintain VBG cord-010092-uftc8inx 5348 17 high high JJ cord-010092-uftc8inx 5348 18 post post JJ cord-010092-uftc8inx 5348 19 - - JJ cord-010092-uftc8inx 5348 20 donation donation JJ cord-010092-uftc8inx 5348 21 safety safety NN cord-010092-uftc8inx 5348 22 standards standard NNS cord-010092-uftc8inx 5348 23 characteristic characteristic NN cord-010092-uftc8inx 5348 24 of of IN cord-010092-uftc8inx 5348 25 Trima Trima NNP cord-010092-uftc8inx 5348 26 Accel Accel NNP cord-010092-uftc8inx 5348 27 . . . cord-010092-uftc8inx 5349 1 Aims aim VBZ cord-010092-uftc8inx 5349 2 : : : cord-010092-uftc8inx 5350 1 The the DT cord-010092-uftc8inx 5350 2 objective objective NN cord-010092-uftc8inx 5350 3 of of IN cord-010092-uftc8inx 5350 4 this this DT cord-010092-uftc8inx 5350 5 evaluation evaluation NN cord-010092-uftc8inx 5350 6 was be VBD cord-010092-uftc8inx 5350 7 to to TO cord-010092-uftc8inx 5350 8 assess assess VB cord-010092-uftc8inx 5350 9 the the DT cord-010092-uftc8inx 5350 10 impact impact NN cord-010092-uftc8inx 5350 11 of of IN cord-010092-uftc8inx 5350 12 TA7 TA7 NNP cord-010092-uftc8inx 5350 13 software software NN cord-010092-uftc8inx 5350 14 by by IN cord-010092-uftc8inx 5350 15 retrospective retrospective JJ cord-010092-uftc8inx 5350 16 comparison comparison NN cord-010092-uftc8inx 5350 17 of of IN cord-010092-uftc8inx 5350 18 procedure procedure NN cord-010092-uftc8inx 5350 19 data datum NNS cord-010092-uftc8inx 5350 20 and and CC cord-010092-uftc8inx 5350 21 potential potential NN cord-010092-uftc8inx 5350 22 for for IN cord-010092-uftc8inx 5350 23 increased increase VBN cord-010092-uftc8inx 5350 24 productivity productivity NN cord-010092-uftc8inx 5350 25 with with IN cord-010092-uftc8inx 5350 26 those those DT cord-010092-uftc8inx 5350 27 of of IN cord-010092-uftc8inx 5350 28 Trima Trima NNP cord-010092-uftc8inx 5350 29 Accel Accel NNP cord-010092-uftc8inx 5350 30 version version NN cord-010092-uftc8inx 5350 31 6 6 CD cord-010092-uftc8inx 5350 32 ( ( -LRB- cord-010092-uftc8inx 5350 33 TA6 TA6 NNP cord-010092-uftc8inx 5350 34 ) ) -RRB- cord-010092-uftc8inx 5350 35 in in IN cord-010092-uftc8inx 5350 36 the the DT cord-010092-uftc8inx 5350 37 same same JJ cord-010092-uftc8inx 5350 38 cohort cohort NN cord-010092-uftc8inx 5350 39 of of IN cord-010092-uftc8inx 5350 40 platelet platelet NN cord-010092-uftc8inx 5350 41 donors donor NNS cord-010092-uftc8inx 5350 42 . . . cord-010092-uftc8inx 5351 1 Methods method NNS cord-010092-uftc8inx 5351 2 : : : cord-010092-uftc8inx 5352 1 Eight eight CD cord-010092-uftc8inx 5352 2 hundred hundred CD cord-010092-uftc8inx 5353 1 twenty twenty CD cord-010092-uftc8inx 5353 2 one one CD cord-010092-uftc8inx 5353 3 procedures procedure NNS cord-010092-uftc8inx 5353 4 , , , cord-010092-uftc8inx 5353 5 started start VBD cord-010092-uftc8inx 5353 6 on on IN cord-010092-uftc8inx 5353 7 TA6 TA6 NNP cord-010092-uftc8inx 5353 8 from from IN cord-010092-uftc8inx 5353 9 4th 4th JJ cord-010092-uftc8inx 5353 10 January January NNP cord-010092-uftc8inx 5353 11 2016 2016 CD cord-010092-uftc8inx 5353 12 to to IN cord-010092-uftc8inx 5353 13 10th 10th JJ cord-010092-uftc8inx 5353 14 October October NNP cord-010092-uftc8inx 5353 15 2017 2017 CD cord-010092-uftc8inx 5353 16 were be VBD cord-010092-uftc8inx 5353 17 compared compare VBN cord-010092-uftc8inx 5353 18 to to IN cord-010092-uftc8inx 5353 19 995 995 CD cord-010092-uftc8inx 5353 20 procedures procedure NNS cord-010092-uftc8inx 5353 21 , , , cord-010092-uftc8inx 5353 22 started start VBD cord-010092-uftc8inx 5353 23 on on IN cord-010092-uftc8inx 5353 24 TA7 TA7 NNP cord-010092-uftc8inx 5353 25 from from IN cord-010092-uftc8inx 5353 26 18th 18th JJ cord-010092-uftc8inx 5353 27 October October NNP cord-010092-uftc8inx 5353 28 2017 2017 CD cord-010092-uftc8inx 5353 29 to to IN cord-010092-uftc8inx 5353 30 31 31 CD cord-010092-uftc8inx 5353 31 st st NNP cord-010092-uftc8inx 5353 32 December December NNP cord-010092-uftc8inx 5353 33 2018 2018 CD cord-010092-uftc8inx 5353 34 . . . cord-010092-uftc8inx 5354 1 Procedural procedural JJ cord-010092-uftc8inx 5354 2 data datum NNS cord-010092-uftc8inx 5354 3 from from IN cord-010092-uftc8inx 5354 4 the the DT cord-010092-uftc8inx 5354 5 Trima Trima NNP cord-010092-uftc8inx 5354 6 devices device NNS cord-010092-uftc8inx 5354 7 were be VBD cord-010092-uftc8inx 5354 8 captured capture VBN cord-010092-uftc8inx 5354 9 using use VBG cord-010092-uftc8inx 5354 10 the the DT cord-010092-uftc8inx 5354 11 Cadence Cadence NNP cord-010092-uftc8inx 5354 12 System System NNP cord-010092-uftc8inx 5354 13 ( ( -LRB- cord-010092-uftc8inx 5354 14 Terumo Terumo NNP cord-010092-uftc8inx 5354 15 BCT BCT NNP cord-010092-uftc8inx 5354 16 , , , cord-010092-uftc8inx 5354 17 Lakewood Lakewood NNP cord-010092-uftc8inx 5354 18 CO CO NNP cord-010092-uftc8inx 5354 19 ) ) -RRB- cord-010092-uftc8inx 5354 20 . . . cord-010092-uftc8inx 5355 1 Parameters parameter NNS cord-010092-uftc8inx 5355 2 investigated investigate VBN cord-010092-uftc8inx 5355 3 were be VBD cord-010092-uftc8inx 5355 4 the the DT cord-010092-uftc8inx 5355 5 number number NN cord-010092-uftc8inx 5355 6 of of IN cord-010092-uftc8inx 5355 7 machine machine NN cord-010092-uftc8inx 5355 8 access access NN cord-010092-uftc8inx 5355 9 pressure pressure NN cord-010092-uftc8inx 5355 10 alerts alert NNS cord-010092-uftc8inx 5355 11 per per IN cord-010092-uftc8inx 5355 12 procedure procedure NN cord-010092-uftc8inx 5355 13 , , , cord-010092-uftc8inx 5355 14 the the DT cord-010092-uftc8inx 5355 15 potential potential NN cord-010092-uftc8inx 5355 16 for for IN cord-010092-uftc8inx 5355 17 higher high JJR cord-010092-uftc8inx 5355 18 platelet platelet NN cord-010092-uftc8inx 5355 19 yield yield NN cord-010092-uftc8inx 5355 20 collections collection NNS cord-010092-uftc8inx 5355 21 and and CC cord-010092-uftc8inx 5355 22 the the DT cord-010092-uftc8inx 5355 23 actual actual JJ cord-010092-uftc8inx 5355 24 collected collect VBD cord-010092-uftc8inx 5355 25 yields yield NNS cord-010092-uftc8inx 5355 26 within within IN cord-010092-uftc8inx 5355 27 the the DT cord-010092-uftc8inx 5355 28 same same JJ cord-010092-uftc8inx 5355 29 cohort cohort NN cord-010092-uftc8inx 5355 30 of of IN cord-010092-uftc8inx 5355 31 platelet platelet NN cord-010092-uftc8inx 5355 32 donors donor NNS cord-010092-uftc8inx 5355 33 . . . cord-010092-uftc8inx 5356 1 Results result NNS cord-010092-uftc8inx 5356 2 : : : cord-010092-uftc8inx 5357 1 Both both DT cord-010092-uftc8inx 5357 2 donor donor NN cord-010092-uftc8inx 5357 3 populations population NNS cord-010092-uftc8inx 5357 4 ( ( -LRB- cord-010092-uftc8inx 5357 5 TA6 TA6 NNP cord-010092-uftc8inx 5357 6 vs. vs. FW cord-010092-uftc8inx 5357 7 TA7 ta7 NN cord-010092-uftc8inx 5357 8 respectively respectively RB cord-010092-uftc8inx 5357 9 ) ) -RRB- cord-010092-uftc8inx 5357 10 were be VBD cord-010092-uftc8inx 5357 11 comparable comparable JJ cord-010092-uftc8inx 5357 12 and and CC cord-010092-uftc8inx 5357 13 were be VBD cord-010092-uftc8inx 5357 14 characterized characterize VBN cord-010092-uftc8inx 5357 15 by by IN cord-010092-uftc8inx 5357 16 : : : cord-010092-uftc8inx 5358 1 TBV tbv NN cord-010092-uftc8inx 5358 2 -5207 -5207 : cord-010092-uftc8inx 5358 3 vs. vs. NN cord-010092-uftc8inx 5358 4 5344 5344 CD cord-010092-uftc8inx 5358 5 mL ml NN cord-010092-uftc8inx 5358 6 ; ; : cord-010092-uftc8inx 5358 7 platelet platelet NN cord-010092-uftc8inx 5358 8 count count NN cord-010092-uftc8inx 5358 9 pre pre JJ cord-010092-uftc8inx 5358 10 - - JJ cord-010092-uftc8inx 5358 11 procedure procedure JJ cord-010092-uftc8inx 5358 12 -252 -252 NN cord-010092-uftc8inx 5359 1 9 9 CD cord-010092-uftc8inx 5359 2 10³/lL 10³/ll CD cord-010092-uftc8inx 5359 3 vs. vs. IN cord-010092-uftc8inx 5359 4 252 252 CD cord-010092-uftc8inx 5359 5 9 9 CD cord-010092-uftc8inx 5359 6 10³/lL 10³/ll CD cord-010092-uftc8inx 5359 7 ; ; : cord-010092-uftc8inx 5359 8 hematocrit hematocrit NN cord-010092-uftc8inx 5359 9 pre pre JJ cord-010092-uftc8inx 5359 10 - - JJ cord-010092-uftc8inx 5359 11 procedure procedure JJ cord-010092-uftc8inx 5359 12 -44 -44 NN cord-010092-uftc8inx 5359 13 % % NN cord-010092-uftc8inx 5359 14 vs. vs. IN cord-010092-uftc8inx 5359 15 44 44 CD cord-010092-uftc8inx 5359 16 % % NN cord-010092-uftc8inx 5359 17 . . . cord-010092-uftc8inx 5360 1 Gender gender NN cord-010092-uftc8inx 5360 2 distribution distribution NN cord-010092-uftc8inx 5360 3 was be VBD cord-010092-uftc8inx 5360 4 11 11 CD cord-010092-uftc8inx 5360 5 % % NN cord-010092-uftc8inx 5360 6 female female NN cord-010092-uftc8inx 5360 7 with with IN cord-010092-uftc8inx 5360 8 TA6 TA6 NNP cord-010092-uftc8inx 5360 9 vs. vs. IN cord-010092-uftc8inx 5360 10 2 2 CD cord-010092-uftc8inx 5360 11 % % NN cord-010092-uftc8inx 5360 12 with with IN cord-010092-uftc8inx 5360 13 TA7 TA7 NNP cord-010092-uftc8inx 5360 14 . . . cord-010092-uftc8inx 5361 1 Venous venous JJ cord-010092-uftc8inx 5361 2 access access NN cord-010092-uftc8inx 5361 3 pressure pressure NN cord-010092-uftc8inx 5361 4 alerts alert NNS cord-010092-uftc8inx 5361 5 were be VBD cord-010092-uftc8inx 5361 6 significantly significantly RB cord-010092-uftc8inx 5361 7 improved improve VBN cord-010092-uftc8inx 5361 8 by by IN cord-010092-uftc8inx 5361 9 TA7 TA7 NNP cord-010092-uftc8inx 5361 10 with with IN cord-010092-uftc8inx 5361 11 an an DT cord-010092-uftc8inx 5361 12 average average NN cord-010092-uftc8inx 5361 13 of of IN cord-010092-uftc8inx 5361 14 0.2 0.2 CD cord-010092-uftc8inx 5361 15 alerts alert NNS cord-010092-uftc8inx 5361 16 per per IN cord-010092-uftc8inx 5361 17 procedure procedure NN cord-010092-uftc8inx 5361 18 as as IN cord-010092-uftc8inx 5361 19 compared compare VBN cord-010092-uftc8inx 5361 20 to to IN cord-010092-uftc8inx 5361 21 2.0 2.0 CD cord-010092-uftc8inx 5361 22 with with IN cord-010092-uftc8inx 5361 23 TA6 TA6 NNP cord-010092-uftc8inx 5361 24 , , , cord-010092-uftc8inx 5361 25 i.e. i.e. FW cord-010092-uftc8inx 5361 26 92 92 CD cord-010092-uftc8inx 5361 27 % % NN cord-010092-uftc8inx 5361 28 decrease decrease NN cord-010092-uftc8inx 5361 29 . . . cord-010092-uftc8inx 5362 1 This this DT cord-010092-uftc8inx 5362 2 decrease decrease NN cord-010092-uftc8inx 5362 3 went go VBD cord-010092-uftc8inx 5362 4 down down RB cord-010092-uftc8inx 5362 5 to to IN cord-010092-uftc8inx 5362 6 91 91 CD cord-010092-uftc8inx 5362 7 % % NN cord-010092-uftc8inx 5362 8 if if IN cord-010092-uftc8inx 5362 9 only only RB cord-010092-uftc8inx 5362 10 male male JJ cord-010092-uftc8inx 5362 11 procedures procedure NNS cord-010092-uftc8inx 5362 12 were be VBD cord-010092-uftc8inx 5362 13 analyzed analyze VBN cord-010092-uftc8inx 5362 14 . . . cord-010092-uftc8inx 5363 1 The the DT cord-010092-uftc8inx 5363 2 maximum maximum JJ cord-010092-uftc8inx 5363 3 number number NN cord-010092-uftc8inx 5363 4 of of IN cord-010092-uftc8inx 5363 5 pressure pressure NN cord-010092-uftc8inx 5363 6 alerts alert NNS cord-010092-uftc8inx 5363 7 went go VBD cord-010092-uftc8inx 5363 8 down down RB cord-010092-uftc8inx 5363 9 by by IN cord-010092-uftc8inx 5363 10 84 84 CD cord-010092-uftc8inx 5363 11 % % NN cord-010092-uftc8inx 5363 12 from from IN cord-010092-uftc8inx 5363 13 90 90 CD cord-010092-uftc8inx 5363 14 alerts alert NNS cord-010092-uftc8inx 5363 15 in in IN cord-010092-uftc8inx 5363 16 one one CD cord-010092-uftc8inx 5363 17 particular particular JJ cord-010092-uftc8inx 5363 18 run run NN cord-010092-uftc8inx 5363 19 in in IN cord-010092-uftc8inx 5363 20 the the DT cord-010092-uftc8inx 5363 21 TA6 TA6 NNP cord-010092-uftc8inx 5363 22 cohort cohort NN cord-010092-uftc8inx 5363 23 to to IN cord-010092-uftc8inx 5363 24 14 14 CD cord-010092-uftc8inx 5363 25 alerts alert NNS cord-010092-uftc8inx 5363 26 in in IN cord-010092-uftc8inx 5363 27 one one CD cord-010092-uftc8inx 5363 28 TA7 TA7 NNP cord-010092-uftc8inx 5363 29 procedure procedure NN cord-010092-uftc8inx 5363 30 . . . cord-010092-uftc8inx 5364 1 Procedure procedure NN cord-010092-uftc8inx 5364 2 time time NN cord-010092-uftc8inx 5364 3 for for IN cord-010092-uftc8inx 5364 4 single single JJ cord-010092-uftc8inx 5364 5 platelet platelet NN cord-010092-uftc8inx 5364 6 products product NNS cord-010092-uftc8inx 5364 7 was be VBD cord-010092-uftc8inx 5364 8 reduced reduce VBN cord-010092-uftc8inx 5364 9 from from IN cord-010092-uftc8inx 5364 10 51 51 CD cord-010092-uftc8inx 5364 11 to to TO cord-010092-uftc8inx 5364 12 49 49 CD cord-010092-uftc8inx 5364 13 min min NN cord-010092-uftc8inx 5364 14 and and CC cord-010092-uftc8inx 5364 15 for for IN cord-010092-uftc8inx 5364 16 double double JJ cord-010092-uftc8inx 5364 17 platelet platelet NN cord-010092-uftc8inx 5364 18 products product NNS cord-010092-uftc8inx 5364 19 from from IN cord-010092-uftc8inx 5364 20 59 59 CD cord-010092-uftc8inx 5364 21 to to TO cord-010092-uftc8inx 5364 22 54 54 CD cord-010092-uftc8inx 5364 23 min min NN cord-010092-uftc8inx 5364 24 ( ( -LRB- cord-010092-uftc8inx 5364 25 TA6 TA6 NNP cord-010092-uftc8inx 5364 26 and and CC cord-010092-uftc8inx 5364 27 TA7 TA7 NNP cord-010092-uftc8inx 5364 28 respectively respectively RB cord-010092-uftc8inx 5364 29 ) ) -RRB- cord-010092-uftc8inx 5364 30 . . . cord-010092-uftc8inx 5365 1 Donor donor NN cord-010092-uftc8inx 5365 2 qualification qualification NN cord-010092-uftc8inx 5365 3 possible possible JJ cord-010092-uftc8inx 5365 4 was be VBD cord-010092-uftc8inx 5365 5 52 52 CD cord-010092-uftc8inx 5365 6 % % NN cord-010092-uftc8inx 5365 7 of of IN cord-010092-uftc8inx 5365 8 procedures procedure NNS cord-010092-uftc8inx 5365 9 yielding yield VBG cord-010092-uftc8inx 5365 10 single single JJ cord-010092-uftc8inx 5365 11 products product NNS cord-010092-uftc8inx 5365 12 and and CC cord-010092-uftc8inx 5365 13 48 48 CD cord-010092-uftc8inx 5365 14 % % NN cord-010092-uftc8inx 5365 15 of of IN cord-010092-uftc8inx 5365 16 procedures procedure NNS cord-010092-uftc8inx 5365 17 yielding yield VBG cord-010092-uftc8inx 5365 18 double double JJ cord-010092-uftc8inx 5365 19 products product NNS cord-010092-uftc8inx 5365 20 with with IN cord-010092-uftc8inx 5365 21 TA6 TA6 NNP cord-010092-uftc8inx 5365 22 . . . cord-010092-uftc8inx 5366 1 The the DT cord-010092-uftc8inx 5366 2 percentage percentage NN cord-010092-uftc8inx 5366 3 of of IN cord-010092-uftc8inx 5366 4 procedures procedure NNS cord-010092-uftc8inx 5366 5 qualifying qualify VBG cord-010092-uftc8inx 5366 6 for for IN cord-010092-uftc8inx 5366 7 doubles double NNS cord-010092-uftc8inx 5366 8 increased increase VBD cord-010092-uftc8inx 5366 9 to to IN cord-010092-uftc8inx 5366 10 91 91 CD cord-010092-uftc8inx 5366 11 % % NN cord-010092-uftc8inx 5366 12 with with IN cord-010092-uftc8inx 5366 13 TA7 TA7 NNP cord-010092-uftc8inx 5366 14 . . . cord-010092-uftc8inx 5367 1 In in IN cord-010092-uftc8inx 5367 2 terms term NNS cord-010092-uftc8inx 5367 3 of of IN cord-010092-uftc8inx 5367 4 split split NN cord-010092-uftc8inx 5367 5 rates rate NNS cord-010092-uftc8inx 5367 6 , , , cord-010092-uftc8inx 5367 7 i.e. i.e. FW cord-010092-uftc8inx 5367 8 how how WRB cord-010092-uftc8inx 5367 9 many many JJ cord-010092-uftc8inx 5367 10 platelet platelet NN cord-010092-uftc8inx 5367 11 doses dose NNS cord-010092-uftc8inx 5367 12 could could MD cord-010092-uftc8inx 5367 13 be be VB cord-010092-uftc8inx 5367 14 produced produce VBN cord-010092-uftc8inx 5367 15 per per IN cord-010092-uftc8inx 5367 16 apheresis apheresis NN cord-010092-uftc8inx 5367 17 collection collection NN cord-010092-uftc8inx 5367 18 , , , cord-010092-uftc8inx 5367 19 potential potential JJ cord-010092-uftc8inx 5367 20 split split NN cord-010092-uftc8inx 5367 21 rates rate NNS cord-010092-uftc8inx 5367 22 increased increase VBD cord-010092-uftc8inx 5367 23 from from IN cord-010092-uftc8inx 5367 24 1.48 1.48 CD cord-010092-uftc8inx 5367 25 to to IN cord-010092-uftc8inx 5367 26 1.91 1.91 CD cord-010092-uftc8inx 5367 27 from from IN cord-010092-uftc8inx 5367 28 TA6 TA6 NNP cord-010092-uftc8inx 5367 29 to to IN cord-010092-uftc8inx 5367 30 TA7 TA7 NNP cord-010092-uftc8inx 5367 31 , , , cord-010092-uftc8inx 5367 32 respectively respectively RB cord-010092-uftc8inx 5367 33 . . . cord-010092-uftc8inx 5368 1 In in IN cord-010092-uftc8inx 5368 2 fact fact NN cord-010092-uftc8inx 5368 3 , , , cord-010092-uftc8inx 5368 4 the the DT cord-010092-uftc8inx 5368 5 observed observed JJ cord-010092-uftc8inx 5368 6 split split NN cord-010092-uftc8inx 5368 7 rate rate NN cord-010092-uftc8inx 5368 8 rose rise VBD cord-010092-uftc8inx 5368 9 modestly modestly RB cord-010092-uftc8inx 5368 10 from from IN cord-010092-uftc8inx 5368 11 1.01 1.01 CD cord-010092-uftc8inx 5368 12 to to IN cord-010092-uftc8inx 5368 13 1.05 1.05 CD cord-010092-uftc8inx 5368 14 , , , cord-010092-uftc8inx 5368 15 as as IN cord-010092-uftc8inx 5368 16 shorter short JJR cord-010092-uftc8inx 5368 17 procedures procedure NNS cord-010092-uftc8inx 5368 18 were be VBD cord-010092-uftc8inx 5368 19 generally generally RB cord-010092-uftc8inx 5368 20 selected select VBN cord-010092-uftc8inx 5368 21 according accord VBG cord-010092-uftc8inx 5368 22 to to IN cord-010092-uftc8inx 5368 23 donors donor NNS cord-010092-uftc8inx 5368 24 ' ' POS cord-010092-uftc8inx 5368 25 preferences preference NNS cord-010092-uftc8inx 5368 26 . . . cord-010092-uftc8inx 5369 1 Summary Summary NNP cord-010092-uftc8inx 5369 2 / / SYM cord-010092-uftc8inx 5369 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 5369 4 : : : cord-010092-uftc8inx 5370 1 In in IN cord-010092-uftc8inx 5370 2 comparable comparable JJ cord-010092-uftc8inx 5370 3 donor donor NN cord-010092-uftc8inx 5370 4 populations population NNS cord-010092-uftc8inx 5370 5 , , , cord-010092-uftc8inx 5370 6 implementation implementation NN cord-010092-uftc8inx 5370 7 of of IN cord-010092-uftc8inx 5370 8 TA7 ta7 NN cord-010092-uftc8inx 5370 9 decreased decrease VBD cord-010092-uftc8inx 5370 10 the the DT cord-010092-uftc8inx 5370 11 number number NN cord-010092-uftc8inx 5370 12 of of IN cord-010092-uftc8inx 5370 13 access access NN cord-010092-uftc8inx 5370 14 pressure pressure NN cord-010092-uftc8inx 5370 15 alerts alert NNS cord-010092-uftc8inx 5370 16 significantly significantly RB cord-010092-uftc8inx 5370 17 compared compare VBN cord-010092-uftc8inx 5370 18 to to IN cord-010092-uftc8inx 5370 19 previous previous JJ cord-010092-uftc8inx 5370 20 Trima Trima NNP cord-010092-uftc8inx 5370 21 versions version NNS cord-010092-uftc8inx 5370 22 . . . cord-010092-uftc8inx 5371 1 The the DT cord-010092-uftc8inx 5371 2 average average JJ cord-010092-uftc8inx 5371 3 procedure procedure NN cord-010092-uftc8inx 5371 4 duration duration NN cord-010092-uftc8inx 5371 5 was be VBD cord-010092-uftc8inx 5371 6 also also RB cord-010092-uftc8inx 5371 7 found find VBN cord-010092-uftc8inx 5371 8 to to TO cord-010092-uftc8inx 5371 9 be be VB cord-010092-uftc8inx 5371 10 slightly slightly RB cord-010092-uftc8inx 5371 11 reduced reduce VBN cord-010092-uftc8inx 5371 12 . . . cord-010092-uftc8inx 5372 1 Implementation implementation NN cord-010092-uftc8inx 5372 2 of of IN cord-010092-uftc8inx 5372 3 TA7 TA7 NNP cord-010092-uftc8inx 5372 4 has have VBZ cord-010092-uftc8inx 5372 5 the the DT cord-010092-uftc8inx 5372 6 potential potential NN cord-010092-uftc8inx 5372 7 to to TO cord-010092-uftc8inx 5372 8 increase increase VB cord-010092-uftc8inx 5372 9 productivity productivity NN cord-010092-uftc8inx 5372 10 significantly significantly RB cord-010092-uftc8inx 5372 11 . . . cord-010092-uftc8inx 5373 1 The the DT cord-010092-uftc8inx 5373 2 observed observed JJ cord-010092-uftc8inx 5373 3 modest modest JJ cord-010092-uftc8inx 5373 4 actual actual JJ cord-010092-uftc8inx 5373 5 rise rise NN cord-010092-uftc8inx 5373 6 in in IN cord-010092-uftc8inx 5373 7 split split NN cord-010092-uftc8inx 5373 8 rate rate NN cord-010092-uftc8inx 5373 9 suggested suggest VBD cord-010092-uftc8inx 5373 10 that that IN cord-010092-uftc8inx 5373 11 factors factor NNS cord-010092-uftc8inx 5373 12 related relate VBN cord-010092-uftc8inx 5373 13 to to IN cord-010092-uftc8inx 5373 14 donor donor NN cord-010092-uftc8inx 5373 15 and and CC cord-010092-uftc8inx 5373 16 inventory inventory NN cord-010092-uftc8inx 5373 17 management management NN cord-010092-uftc8inx 5373 18 will will MD cord-010092-uftc8inx 5373 19 determine determine VB cord-010092-uftc8inx 5373 20 at at IN cord-010092-uftc8inx 5373 21 which which WDT cord-010092-uftc8inx 5373 22 extent extent NN cord-010092-uftc8inx 5373 23 the the DT cord-010092-uftc8inx 5373 24 potential potential NN cord-010092-uftc8inx 5373 25 of of IN cord-010092-uftc8inx 5373 26 the the DT cord-010092-uftc8inx 5373 27 new new JJ cord-010092-uftc8inx 5373 28 software software NN cord-010092-uftc8inx 5373 29 will will MD cord-010092-uftc8inx 5373 30 be be VB cord-010092-uftc8inx 5373 31 used use VBN cord-010092-uftc8inx 5373 32 . . . cord-010092-uftc8inx 5374 1 DONOR donor NN cord-010092-uftc8inx 5374 2 COMPARED compared IN cord-010092-uftc8inx 5374 3 EXPERIENCE experience NN cord-010092-uftc8inx 5374 4 ON on IN cord-010092-uftc8inx 5374 5 TRIMA TRIMA NNP cord-010092-uftc8inx 5374 6 ACCEL ACCEL NNP cord-010092-uftc8inx 5374 7 7 7 CD cord-010092-uftc8inx 5374 8 TO to IN cord-010092-uftc8inx 5374 9 TRIMA TRIMA NNP cord-010092-uftc8inx 5374 10 ACCEL ACCEL NNP cord-010092-uftc8inx 5374 11 VERSION version NN cord-010092-uftc8inx 5374 12 6 6 CD cord-010092-uftc8inx 5374 13 August August NNP cord-010092-uftc8inx 5374 14 11 11 CD cord-010092-uftc8inx 5374 15 2017 2017 CD cord-010092-uftc8inx 5374 16 to to IN cord-010092-uftc8inx 5374 17 October October NNP cord-010092-uftc8inx 5374 18 17 17 CD cord-010092-uftc8inx 5374 19 2017 2017 CD cord-010092-uftc8inx 5374 20 or or CC cord-010092-uftc8inx 5374 21 Trima Trima NNP cord-010092-uftc8inx 5374 22 Accel Accel NNP cord-010092-uftc8inx 5374 23 7 7 CD cord-010092-uftc8inx 5374 24 during during IN cord-010092-uftc8inx 5374 25 the the DT cord-010092-uftc8inx 5374 26 Test test NN cord-010092-uftc8inx 5374 27 period period NN cord-010092-uftc8inx 5374 28 from from IN cord-010092-uftc8inx 5374 29 November November NNP cord-010092-uftc8inx 5374 30 28 28 CD cord-010092-uftc8inx 5374 31 2017 2017 CD cord-010092-uftc8inx 5374 32 to to IN cord-010092-uftc8inx 5374 33 January January NNP cord-010092-uftc8inx 5374 34 9 9 CD cord-010092-uftc8inx 5374 35 2018 2018 CD cord-010092-uftc8inx 5374 36 . . . cord-010092-uftc8inx 5375 1 This this DT cord-010092-uftc8inx 5375 2 was be VBD cord-010092-uftc8inx 5375 3 not not RB cord-010092-uftc8inx 5375 4 a a DT cord-010092-uftc8inx 5375 5 paired paired JJ cord-010092-uftc8inx 5375 6 study study NN cord-010092-uftc8inx 5375 7 . . . cord-010092-uftc8inx 5376 1 Donors donor NNS cord-010092-uftc8inx 5376 2 completed complete VBD cord-010092-uftc8inx 5376 3 the the DT cord-010092-uftc8inx 5376 4 survey survey NN cord-010092-uftc8inx 5376 5 while while IN cord-010092-uftc8inx 5376 6 recovering recover VBG cord-010092-uftc8inx 5376 7 from from IN cord-010092-uftc8inx 5376 8 the the DT cord-010092-uftc8inx 5376 9 apheresis apheresis NN cord-010092-uftc8inx 5376 10 procedure procedure NN cord-010092-uftc8inx 5376 11 in in IN cord-010092-uftc8inx 5376 12 the the DT cord-010092-uftc8inx 5376 13 cantina cantina NN cord-010092-uftc8inx 5376 14 . . . cord-010092-uftc8inx 5377 1 Results result NNS cord-010092-uftc8inx 5377 2 from from IN cord-010092-uftc8inx 5377 3 the the DT cord-010092-uftc8inx 5377 4 paper paper NN cord-010092-uftc8inx 5377 5 survey survey NN cord-010092-uftc8inx 5377 6 were be VBD cord-010092-uftc8inx 5377 7 transcribed transcribe VBN cord-010092-uftc8inx 5377 8 into into IN cord-010092-uftc8inx 5377 9 EXCEL EXCEL NNP cord-010092-uftc8inx 5377 10 for for IN cord-010092-uftc8inx 5377 11 analysis analysis NN cord-010092-uftc8inx 5377 12 . . . cord-010092-uftc8inx 5378 1 Results result NNS cord-010092-uftc8inx 5378 2 : : : cord-010092-uftc8inx 5379 1 63 63 CD cord-010092-uftc8inx 5379 2 donors donor NNS cord-010092-uftc8inx 5379 3 completed complete VBD cord-010092-uftc8inx 5379 4 the the DT cord-010092-uftc8inx 5379 5 survey survey NN cord-010092-uftc8inx 5379 6 during during IN cord-010092-uftc8inx 5379 7 the the DT cord-010092-uftc8inx 5379 8 Control Control NNP cord-010092-uftc8inx 5379 9 period period NN cord-010092-uftc8inx 5379 10 whereas whereas IN cord-010092-uftc8inx 5379 11 86 86 CD cord-010092-uftc8inx 5379 12 donors donor NNS cord-010092-uftc8inx 5379 13 completed complete VBD cord-010092-uftc8inx 5379 14 the the DT cord-010092-uftc8inx 5379 15 survey survey NN cord-010092-uftc8inx 5379 16 during during IN cord-010092-uftc8inx 5379 17 the the DT cord-010092-uftc8inx 5379 18 Test Test NNP cord-010092-uftc8inx 5379 19 period period NN cord-010092-uftc8inx 5379 20 . . . cord-010092-uftc8inx 5380 1 The the DT cord-010092-uftc8inx 5380 2 mean mean JJ cord-010092-uftc8inx 5380 3 number number NN cord-010092-uftc8inx 5380 4 of of IN cord-010092-uftc8inx 5380 5 previous previous JJ cord-010092-uftc8inx 5380 6 donations donation NNS cord-010092-uftc8inx 5380 7 for for IN cord-010092-uftc8inx 5380 8 the the DT cord-010092-uftc8inx 5380 9 Control Control NNP cord-010092-uftc8inx 5380 10 period period NN cord-010092-uftc8inx 5380 11 was be VBD cord-010092-uftc8inx 5380 12 3.0 3.0 CD cord-010092-uftc8inx 5380 13 ( ( -LRB- cord-010092-uftc8inx 5380 14 min min NNP cord-010092-uftc8inx 5380 15 1 1 CD cord-010092-uftc8inx 5380 16 max max NNP cord-010092-uftc8inx 5380 17 6 6 CD cord-010092-uftc8inx 5380 18 ) ) -RRB- cord-010092-uftc8inx 5380 19 and and CC cord-010092-uftc8inx 5380 20 for for IN cord-010092-uftc8inx 5380 21 the the DT cord-010092-uftc8inx 5380 22 Test test NN cord-010092-uftc8inx 5380 23 period period NN cord-010092-uftc8inx 5380 24 was be VBD cord-010092-uftc8inx 5380 25 3.2 3.2 CD cord-010092-uftc8inx 5380 26 ( ( -LRB- cord-010092-uftc8inx 5380 27 min min NN cord-010092-uftc8inx 5380 28 0 0 CD cord-010092-uftc8inx 5380 29 max max NNP cord-010092-uftc8inx 5380 30 7 7 CD cord-010092-uftc8inx 5380 31 ) ) -RRB- cord-010092-uftc8inx 5380 32 . . . cord-010092-uftc8inx 5381 1 There there EX cord-010092-uftc8inx 5381 2 were be VBD cord-010092-uftc8inx 5381 3 no no DT cord-010092-uftc8inx 5381 4 first first JJ cord-010092-uftc8inx 5381 5 time time NN cord-010092-uftc8inx 5381 6 donors donor NNS cord-010092-uftc8inx 5381 7 during during IN cord-010092-uftc8inx 5381 8 the the DT cord-010092-uftc8inx 5381 9 Control Control NNP cord-010092-uftc8inx 5381 10 period period NN cord-010092-uftc8inx 5381 11 and and CC cord-010092-uftc8inx 5381 12 20 20 CD cord-010092-uftc8inx 5381 13 first first JJ cord-010092-uftc8inx 5381 14 time time NN cord-010092-uftc8inx 5381 15 donors donor NNS cord-010092-uftc8inx 5381 16 during during IN cord-010092-uftc8inx 5381 17 the the DT cord-010092-uftc8inx 5381 18 Test test NN cord-010092-uftc8inx 5381 19 period period NN cord-010092-uftc8inx 5381 20 . . . cord-010092-uftc8inx 5382 1 91 91 CD cord-010092-uftc8inx 5382 2 % % NN cord-010092-uftc8inx 5382 3 of of IN cord-010092-uftc8inx 5382 4 donors donor NNS cord-010092-uftc8inx 5382 5 rated rate VBD cord-010092-uftc8inx 5382 6 their -PRON- PRP$ cord-010092-uftc8inx 5382 7 overall overall JJ cord-010092-uftc8inx 5382 8 donation donation NN cord-010092-uftc8inx 5382 9 experience experience NN cord-010092-uftc8inx 5382 10 as as RB cord-010092-uftc8inx 5382 11 good good JJ cord-010092-uftc8inx 5382 12 on on IN cord-010092-uftc8inx 5382 13 Trima Trima NNP cord-010092-uftc8inx 5382 14 Accel Accel NNP cord-010092-uftc8inx 5382 15 7 7 CD cord-010092-uftc8inx 5382 16 compared compare VBD cord-010092-uftc8inx 5382 17 to to IN cord-010092-uftc8inx 5382 18 90 90 CD cord-010092-uftc8inx 5382 19 % % NN cord-010092-uftc8inx 5382 20 on on IN cord-010092-uftc8inx 5382 21 Trima Trima NNP cord-010092-uftc8inx 5382 22 Accel Accel NNP cord-010092-uftc8inx 5382 23 Version Version NNP cord-010092-uftc8inx 5382 24 6 6 CD cord-010092-uftc8inx 5382 25 . . . cord-010092-uftc8inx 5383 1 Zero zero CD cord-010092-uftc8inx 5384 1 ( ( -LRB- cord-010092-uftc8inx 5384 2 0 0 NFP cord-010092-uftc8inx 5384 3 ) ) -RRB- cord-010092-uftc8inx 5384 4 donor donor NN cord-010092-uftc8inx 5384 5 rated rate VBD cord-010092-uftc8inx 5384 6 their -PRON- PRP$ cord-010092-uftc8inx 5384 7 experience experience NN cord-010092-uftc8inx 5384 8 on on IN cord-010092-uftc8inx 5384 9 either either CC cord-010092-uftc8inx 5384 10 Trima Trima NNP cord-010092-uftc8inx 5384 11 Accel Accel NNP cord-010092-uftc8inx 5384 12 device device NN cord-010092-uftc8inx 5384 13 as as IN cord-010092-uftc8inx 5384 14 poor poor JJ cord-010092-uftc8inx 5384 15 . . . cord-010092-uftc8inx 5385 1 100 100 CD cord-010092-uftc8inx 5385 2 % % NN cord-010092-uftc8inx 5385 3 of of IN cord-010092-uftc8inx 5385 4 donors donor NNS cord-010092-uftc8inx 5385 5 who who WP cord-010092-uftc8inx 5385 6 responded respond VBD cord-010092-uftc8inx 5385 7 to to IN cord-010092-uftc8inx 5385 8 the the DT cord-010092-uftc8inx 5385 9 question question NN cord-010092-uftc8inx 5385 10 said say VBD cord-010092-uftc8inx 5385 11 they -PRON- PRP cord-010092-uftc8inx 5385 12 would would MD cord-010092-uftc8inx 5385 13 donate donate VB cord-010092-uftc8inx 5385 14 on on IN cord-010092-uftc8inx 5385 15 Trima Trima NNP cord-010092-uftc8inx 5385 16 Accel Accel NNP cord-010092-uftc8inx 5385 17 7 7 CD cord-010092-uftc8inx 5385 18 again again RB cord-010092-uftc8inx 5385 19 . . . cord-010092-uftc8inx 5386 1 Summary Summary NNP cord-010092-uftc8inx 5386 2 / / SYM cord-010092-uftc8inx 5386 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 5386 4 : : : cord-010092-uftc8inx 5387 1 No no DT cord-010092-uftc8inx 5387 2 significant significant JJ cord-010092-uftc8inx 5387 3 difference difference NN cord-010092-uftc8inx 5387 4 was be VBD cord-010092-uftc8inx 5387 5 observed observe VBN cord-010092-uftc8inx 5387 6 in in IN cord-010092-uftc8inx 5387 7 donor donor NN cord-010092-uftc8inx 5387 8 experience experience NN cord-010092-uftc8inx 5387 9 between between IN cord-010092-uftc8inx 5387 10 Trima Trima NNP cord-010092-uftc8inx 5387 11 Accel Accel NNP cord-010092-uftc8inx 5387 12 Version Version NNP cord-010092-uftc8inx 5387 13 6 6 CD cord-010092-uftc8inx 5387 14 and and CC cord-010092-uftc8inx 5387 15 Trima Trima NNP cord-010092-uftc8inx 5387 16 Accel Accel NNP cord-010092-uftc8inx 5387 17 7 7 CD cord-010092-uftc8inx 5387 18 as as IN cord-010092-uftc8inx 5387 19 both both DT cord-010092-uftc8inx 5387 20 versions version NNS cord-010092-uftc8inx 5387 21 receive receive VBP cord-010092-uftc8inx 5387 22 high high JJ cord-010092-uftc8inx 5387 23 marks mark NNS cord-010092-uftc8inx 5387 24 . . . cord-010092-uftc8inx 5388 1 Background background NN cord-010092-uftc8inx 5388 2 : : : cord-010092-uftc8inx 5389 1 The the DT cord-010092-uftc8inx 5389 2 trend trend NN cord-010092-uftc8inx 5389 3 on on IN cord-010092-uftc8inx 5389 4 growth growth NN cord-010092-uftc8inx 5389 5 of of IN cord-010092-uftc8inx 5389 6 query query NN cord-010092-uftc8inx 5389 7 for for IN cord-010092-uftc8inx 5390 1 donor donor NN cord-010092-uftc8inx 5390 2 platelet platelet NN cord-010092-uftc8inx 5390 3 concentrates concentrate VBZ cord-010092-uftc8inx 5390 4 is be VBZ cord-010092-uftc8inx 5390 5 observed observe VBN cord-010092-uftc8inx 5390 6 in in IN cord-010092-uftc8inx 5390 7 Russia Russia NNP cord-010092-uftc8inx 5390 8 for for IN cord-010092-uftc8inx 5390 9 past past JJ cord-010092-uftc8inx 5390 10 few few JJ cord-010092-uftc8inx 5390 11 years year NNS cord-010092-uftc8inx 5390 12 . . . cord-010092-uftc8inx 5391 1 As as IN cord-010092-uftc8inx 5391 2 reported report VBN cord-010092-uftc8inx 5391 3 by by IN cord-010092-uftc8inx 5391 4 EDQM EDQM NNP cord-010092-uftc8inx 5391 5 in in IN cord-010092-uftc8inx 5391 6 2014 2014 CD cord-010092-uftc8inx 5391 7 , , , cord-010092-uftc8inx 5391 8 a a DT cord-010092-uftc8inx 5391 9 higher high JJR cord-010092-uftc8inx 5391 10 number number NN cord-010092-uftc8inx 5391 11 of of IN cord-010092-uftc8inx 5391 12 the the DT cord-010092-uftc8inx 5391 13 platelets platelet NNS cord-010092-uftc8inx 5391 14 was be VBD cord-010092-uftc8inx 5391 15 consumed consume VBN cord-010092-uftc8inx 5391 16 compare compare VBP cord-010092-uftc8inx 5391 17 to to IN cord-010092-uftc8inx 5391 18 2011 2011 CD cord-010092-uftc8inx 5391 19 by by IN cord-010092-uftc8inx 5391 20 7.8 7.8 CD cord-010092-uftc8inx 5391 21 % % NN cord-010092-uftc8inx 5391 22 . . . cord-010092-uftc8inx 5392 1 Patients patient NNS cord-010092-uftc8inx 5392 2 ' ' POS cord-010092-uftc8inx 5392 3 with with IN cord-010092-uftc8inx 5392 4 hematological hematological JJ cord-010092-uftc8inx 5392 5 malignancies malignancy NNS cord-010092-uftc8inx 5392 6 treatment treatment NN cord-010092-uftc8inx 5392 7 requires require VBZ cord-010092-uftc8inx 5392 8 platelet platelet NN cord-010092-uftc8inx 5392 9 concentrates concentrate VBZ cord-010092-uftc8inx 5392 10 transfusions transfusion NNS cord-010092-uftc8inx 5392 11 during during IN cord-010092-uftc8inx 5392 12 chemotherapy chemotherapy NN cord-010092-uftc8inx 5392 13 , , , cord-010092-uftc8inx 5392 14 immunotherapy immunotherapy NN cord-010092-uftc8inx 5392 15 and and CC cord-010092-uftc8inx 5392 16 hematopoietic hematopoietic JJ cord-010092-uftc8inx 5392 17 stem stem NN cord-010092-uftc8inx 5392 18 cells cell NNS cord-010092-uftc8inx 5392 19 transplantation transplantation NN cord-010092-uftc8inx 5392 20 . . . cord-010092-uftc8inx 5393 1 According accord VBG cord-010092-uftc8inx 5393 2 to to IN cord-010092-uftc8inx 5393 3 the the DT cord-010092-uftc8inx 5393 4 data datum NNS cord-010092-uftc8inx 5393 5 collected collect VBN cord-010092-uftc8inx 5393 6 in in IN cord-010092-uftc8inx 5393 7 National National NNP cord-010092-uftc8inx 5393 8 Research Research NNP cord-010092-uftc8inx 5393 9 Center Center NNP cord-010092-uftc8inx 5393 10 for for IN cord-010092-uftc8inx 5393 11 Hematology Hematology NNP cord-010092-uftc8inx 5393 12 ( ( -LRB- cord-010092-uftc8inx 5393 13 NRCH NRCH NNP cord-010092-uftc8inx 5393 14 ) ) -RRB- cord-010092-uftc8inx 5393 15 in in IN cord-010092-uftc8inx 5393 16 2018 2018 CD cord-010092-uftc8inx 5393 17 , , , cord-010092-uftc8inx 5393 18 635 635 CD cord-010092-uftc8inx 5393 19 ( ( -LRB- cord-010092-uftc8inx 5393 20 8.6 8.6 CD cord-010092-uftc8inx 5393 21 % % NN cord-010092-uftc8inx 5393 22 ) ) -RRB- cord-010092-uftc8inx 5393 23 of of IN cord-010092-uftc8inx 5393 24 the the DT cord-010092-uftc8inx 5393 25 7,371 7,371 CD cord-010092-uftc8inx 5393 26 patients patient NNS cord-010092-uftc8inx 5393 27 , , , cord-010092-uftc8inx 5393 28 treated treat VBN cord-010092-uftc8inx 5393 29 within within IN cord-010092-uftc8inx 5393 30 facility facility NN cord-010092-uftc8inx 5393 31 , , , cord-010092-uftc8inx 5393 32 received receive VBD cord-010092-uftc8inx 5393 33 platelet platelet NN cord-010092-uftc8inx 5393 34 transfusions transfusion NNS cord-010092-uftc8inx 5393 35 as as IN cord-010092-uftc8inx 5393 36 transfusion transfusion NN cord-010092-uftc8inx 5393 37 therapy therapy NN cord-010092-uftc8inx 5393 38 . . . cord-010092-uftc8inx 5394 1 The the DT cord-010092-uftc8inx 5394 2 total total JJ cord-010092-uftc8inx 5394 3 number number NN cord-010092-uftc8inx 5394 4 transfused transfuse VBN cord-010092-uftc8inx 5394 5 units unit NNS cord-010092-uftc8inx 5394 6 is be VBZ cord-010092-uftc8inx 5394 7 14,292 14,292 CD cord-010092-uftc8inx 5394 8 , , , cord-010092-uftc8inx 5394 9 which which WDT cord-010092-uftc8inx 5394 10 is be VBZ cord-010092-uftc8inx 5394 11 668 668 CD cord-010092-uftc8inx 5394 12 higher high JJR cord-010092-uftc8inx 5394 13 ( ( -LRB- cord-010092-uftc8inx 5394 14 by by IN cord-010092-uftc8inx 5394 15 4.9 4.9 CD cord-010092-uftc8inx 5394 16 % % NN cord-010092-uftc8inx 5394 17 ) ) -RRB- cord-010092-uftc8inx 5394 18 comparing compare VBG cord-010092-uftc8inx 5394 19 to to IN cord-010092-uftc8inx 5394 20 2017 2017 CD cord-010092-uftc8inx 5394 21 . . . cord-010092-uftc8inx 5395 1 Platelet platelet NN cord-010092-uftc8inx 5395 2 concentrates concentrate VBZ cord-010092-uftc8inx 5395 3 production production NN cord-010092-uftc8inx 5395 4 can can MD cord-010092-uftc8inx 5395 5 be be VB cord-010092-uftc8inx 5395 6 performed perform VBN cord-010092-uftc8inx 5395 7 either either CC cord-010092-uftc8inx 5395 8 by by IN cord-010092-uftc8inx 5395 9 apheresis apheresis NN cord-010092-uftc8inx 5395 10 process process NN cord-010092-uftc8inx 5395 11 or or CC cord-010092-uftc8inx 5395 12 by by IN cord-010092-uftc8inx 5395 13 pooling pool VBG cord-010092-uftc8inx 5395 14 individual individual JJ cord-010092-uftc8inx 5395 15 units unit NNS cord-010092-uftc8inx 5395 16 recovered recover VBN cord-010092-uftc8inx 5395 17 from from IN cord-010092-uftc8inx 5395 18 the the DT cord-010092-uftc8inx 5395 19 whole whole JJ cord-010092-uftc8inx 5395 20 blood blood NN cord-010092-uftc8inx 5395 21 . . . cord-010092-uftc8inx 5396 1 Taking take VBG cord-010092-uftc8inx 5396 2 into into IN cord-010092-uftc8inx 5396 3 account account NN cord-010092-uftc8inx 5396 4 that that IN cord-010092-uftc8inx 5396 5 the the DT cord-010092-uftc8inx 5396 6 NRCH NRCH NNP cord-010092-uftc8inx 5396 7 produces produce VBZ cord-010092-uftc8inx 5396 8 blood blood NN cord-010092-uftc8inx 5396 9 units unit NNS cord-010092-uftc8inx 5396 10 for for IN cord-010092-uftc8inx 5396 11 its -PRON- PRP$ cord-010092-uftc8inx 5396 12 own own JJ cord-010092-uftc8inx 5396 13 needs need NNS cord-010092-uftc8inx 5396 14 , , , cord-010092-uftc8inx 5396 15 the the DT cord-010092-uftc8inx 5396 16 pooling pooling NN cord-010092-uftc8inx 5396 17 is be VBZ cord-010092-uftc8inx 5396 18 not not RB cord-010092-uftc8inx 5396 19 suitable suitable JJ cord-010092-uftc8inx 5396 20 method method NN cord-010092-uftc8inx 5396 21 for for IN cord-010092-uftc8inx 5396 22 production production NN cord-010092-uftc8inx 5396 23 because because IN cord-010092-uftc8inx 5396 24 its -PRON- PRP$ cord-010092-uftc8inx 5396 25 implementation implementation NN cord-010092-uftc8inx 5396 26 does do VBZ cord-010092-uftc8inx 5396 27 n't not RB cord-010092-uftc8inx 5396 28 cover cover VB cord-010092-uftc8inx 5396 29 require require JJ cord-010092-uftc8inx 5396 30 for for IN cord-010092-uftc8inx 5396 31 platelets platelet NNS cord-010092-uftc8inx 5396 32 and and CC cord-010092-uftc8inx 5396 33 overproduces overproduce VBZ cord-010092-uftc8inx 5396 34 RBCs rbc NNS cord-010092-uftc8inx 5396 35 . . . cord-010092-uftc8inx 5397 1 That that DT cord-010092-uftc8inx 5397 2 is be VBZ cord-010092-uftc8inx 5397 3 why why WRB cord-010092-uftc8inx 5397 4 platelet platelet NN cord-010092-uftc8inx 5397 5 concentrates concentrate VBZ cord-010092-uftc8inx 5397 6 in in IN cord-010092-uftc8inx 5397 7 NRCH NRCH NNP cord-010092-uftc8inx 5397 8 are be VBP cord-010092-uftc8inx 5397 9 obtained obtain VBN cord-010092-uftc8inx 5397 10 by by IN cord-010092-uftc8inx 5397 11 apheresis apheresis NN cord-010092-uftc8inx 5397 12 only only RB cord-010092-uftc8inx 5397 13 . . . cord-010092-uftc8inx 5398 1 In in IN cord-010092-uftc8inx 5398 2 summary summary NN cord-010092-uftc8inx 5398 3 , , , cord-010092-uftc8inx 5398 4 the the DT cord-010092-uftc8inx 5398 5 growth growth NN cord-010092-uftc8inx 5398 6 on on IN cord-010092-uftc8inx 5398 7 requirement requirement NN cord-010092-uftc8inx 5398 8 for for IN cord-010092-uftc8inx 5398 9 platelet platelet NN cord-010092-uftc8inx 5398 10 concentrates concentrate NNS cord-010092-uftc8inx 5398 11 and and CC cord-010092-uftc8inx 5398 12 their -PRON- PRP$ cord-010092-uftc8inx 5398 13 safeness safeness NN cord-010092-uftc8inx 5398 14 explains explain VBZ cord-010092-uftc8inx 5398 15 the the DT cord-010092-uftc8inx 5398 16 need need NN cord-010092-uftc8inx 5398 17 for for IN cord-010092-uftc8inx 5398 18 a a DT cord-010092-uftc8inx 5398 19 comparative comparative JJ cord-010092-uftc8inx 5398 20 study study NN cord-010092-uftc8inx 5398 21 for for IN cord-010092-uftc8inx 5398 22 effectiveness effectiveness NN cord-010092-uftc8inx 5398 23 of of IN cord-010092-uftc8inx 5398 24 platelet platelet NN cord-010092-uftc8inx 5398 25 production production NN cord-010092-uftc8inx 5398 26 using use VBG cord-010092-uftc8inx 5398 27 various various JJ cord-010092-uftc8inx 5398 28 apheresis apheresis NN cord-010092-uftc8inx 5398 29 systems system NNS cord-010092-uftc8inx 5398 30 . . . cord-010092-uftc8inx 5399 1 Aims aim VBZ cord-010092-uftc8inx 5399 2 : : : cord-010092-uftc8inx 5400 1 The the DT cord-010092-uftc8inx 5400 2 aim aim NN cord-010092-uftc8inx 5400 3 of of IN cord-010092-uftc8inx 5400 4 the the DT cord-010092-uftc8inx 5400 5 study study NN cord-010092-uftc8inx 5400 6 is be VBZ cord-010092-uftc8inx 5400 7 to to TO cord-010092-uftc8inx 5400 8 compare compare VB cord-010092-uftc8inx 5400 9 effectiveness effectiveness NN cord-010092-uftc8inx 5400 10 of of IN cord-010092-uftc8inx 5400 11 platelet platelet NN cord-010092-uftc8inx 5400 12 concentrate concentrate NN cord-010092-uftc8inx 5400 13 production production NN cord-010092-uftc8inx 5400 14 using use VBG cord-010092-uftc8inx 5400 15 MCS MCS NNP cord-010092-uftc8inx 5400 16 + + SYM cord-010092-uftc8inx 5400 17 9000 9000 CD cord-010092-uftc8inx 5400 18 ( ( -LRB- cord-010092-uftc8inx 5400 19 Haemonetics Haemonetics NNP cord-010092-uftc8inx 5400 20 ) ) -RRB- cord-010092-uftc8inx 5400 21 , , , cord-010092-uftc8inx 5400 22 UPP UPP NNP cord-010092-uftc8inx 5400 23 and and CC cord-010092-uftc8inx 5400 24 Trima Trima NNP cord-010092-uftc8inx 5400 25 Accel Accel NNP cord-010092-uftc8inx 5401 1 ( ( -LRB- cord-010092-uftc8inx 5401 2 Terumo Terumo NNP cord-010092-uftc8inx 5401 3 BCT BCT NNP cord-010092-uftc8inx 5401 4 ) ) -RRB- cord-010092-uftc8inx 5401 5 version version NN cord-010092-uftc8inx 5401 6 6.0 6.0 CD cord-010092-uftc8inx 5401 7 protocols protocol NNS cord-010092-uftc8inx 5401 8 . . . cord-010092-uftc8inx 5402 1 Methods method NNS cord-010092-uftc8inx 5402 2 : : : cord-010092-uftc8inx 5402 3 The the DT cord-010092-uftc8inx 5402 4 data datum NNS cord-010092-uftc8inx 5402 5 for for IN cord-010092-uftc8inx 5402 6 4868 4868 CD cord-010092-uftc8inx 5402 7 protocols protocol NNS cord-010092-uftc8inx 5402 8 of of IN cord-010092-uftc8inx 5402 9 platelet platelet NN cord-010092-uftc8inx 5402 10 donations donation NNS cord-010092-uftc8inx 5402 11 performed perform VBN cord-010092-uftc8inx 5402 12 in in IN cord-010092-uftc8inx 5402 13 2018 2018 CD cord-010092-uftc8inx 5402 14 were be VBD cord-010092-uftc8inx 5402 15 analyzed analyze VBN cord-010092-uftc8inx 5402 16 : : : cord-010092-uftc8inx 5402 17 2773 2773 CD cord-010092-uftc8inx 5402 18 on on IN cord-010092-uftc8inx 5402 19 Trima Trima NNP cord-010092-uftc8inx 5402 20 Accel Accel NNP cord-010092-uftc8inx 5402 21 and and CC cord-010092-uftc8inx 5402 22 2095 2095 CD cord-010092-uftc8inx 5402 23 on on IN cord-010092-uftc8inx 5402 24 MSC MSC NNP cord-010092-uftc8inx 5402 25 + + CC cord-010092-uftc8inx 5402 26 9000 9000 CD cord-010092-uftc8inx 5402 27 . . . cord-010092-uftc8inx 5403 1 All all DT cord-010092-uftc8inx 5403 2 donors donor NNS cord-010092-uftc8inx 5403 3 were be VBD cord-010092-uftc8inx 5403 4 voluntary voluntary JJ cord-010092-uftc8inx 5403 5 and and CC cord-010092-uftc8inx 5403 6 non non JJ cord-010092-uftc8inx 5403 7 - - JJ cord-010092-uftc8inx 5403 8 paid pay VBN cord-010092-uftc8inx 5403 9 donors donor NNS cord-010092-uftc8inx 5403 10 with with IN cord-010092-uftc8inx 5403 11 previous previous JJ cord-010092-uftc8inx 5403 12 experience experience NN cord-010092-uftc8inx 5403 13 of of IN cord-010092-uftc8inx 5403 14 blood blood NN cord-010092-uftc8inx 5403 15 donations donation NNS cord-010092-uftc8inx 5403 16 . . . cord-010092-uftc8inx 5404 1 The the DT cord-010092-uftc8inx 5404 2 choice choice NN cord-010092-uftc8inx 5404 3 of of IN cord-010092-uftc8inx 5404 4 the the DT cord-010092-uftc8inx 5404 5 platelet platelet NN cord-010092-uftc8inx 5404 6 collection collection NN cord-010092-uftc8inx 5404 7 device device NN cord-010092-uftc8inx 5404 8 was be VBD cord-010092-uftc8inx 5404 9 random random JJ cord-010092-uftc8inx 5404 10 ; ; : cord-010092-uftc8inx 5404 11 analysis analysis NN cord-010092-uftc8inx 5404 12 of of IN cord-010092-uftc8inx 5404 13 the the DT cord-010092-uftc8inx 5404 14 main main JJ cord-010092-uftc8inx 5404 15 characteristics characteristic NNS cord-010092-uftc8inx 5404 16 of of IN cord-010092-uftc8inx 5404 17 donors donor NNS cord-010092-uftc8inx 5404 18 did do VBD cord-010092-uftc8inx 5404 19 not not RB cord-010092-uftc8inx 5404 20 reveal reveal VB cord-010092-uftc8inx 5404 21 any any DT cord-010092-uftc8inx 5404 22 significant significant JJ cord-010092-uftc8inx 5404 23 differences difference NNS cord-010092-uftc8inx 5404 24 between between IN cord-010092-uftc8inx 5404 25 the the DT cord-010092-uftc8inx 5404 26 groups group NNS cord-010092-uftc8inx 5404 27 . . . cord-010092-uftc8inx 5405 1 The the DT cord-010092-uftc8inx 5405 2 median median JJ cord-010092-uftc8inx 5405 3 age age NN cord-010092-uftc8inx 5405 4 of of IN cord-010092-uftc8inx 5405 5 the the DT cord-010092-uftc8inx 5405 6 donor donor NN cord-010092-uftc8inx 5405 7 was be VBD cord-010092-uftc8inx 5405 8 32 32 CD cord-010092-uftc8inx 5405 9 years year NNS cord-010092-uftc8inx 5405 10 old old JJ cord-010092-uftc8inx 5405 11 , , , cord-010092-uftc8inx 5405 12 height height NN cord-010092-uftc8inx 5405 13 -175 -175 NNP cord-010092-uftc8inx 5405 14 cm cm NNP cord-010092-uftc8inx 5405 15 , , , cord-010092-uftc8inx 5406 1 weight weight NN cord-010092-uftc8inx 5406 2 -76 -76 NNP cord-010092-uftc8inx 5406 3 kg kg NNS cord-010092-uftc8inx 5406 4 , , , cord-010092-uftc8inx 5406 5 platelet platelet NN cord-010092-uftc8inx 5406 6 count count NN cord-010092-uftc8inx 5406 7 before before IN cord-010092-uftc8inx 5406 8 donation donation NN cord-010092-uftc8inx 5406 9 -254 -254 NN cord-010092-uftc8inx 5406 10 9 9 CD cord-010092-uftc8inx 5406 11 10 10 CD cord-010092-uftc8inx 5406 12 9 9 CD cord-010092-uftc8inx 5406 13 /L /l CD cord-010092-uftc8inx 5406 14 , , , cord-010092-uftc8inx 5406 15 hematocrit hematocrit NN cord-010092-uftc8inx 5406 16 -42 -42 JJR cord-010092-uftc8inx 5406 17 % % NN cord-010092-uftc8inx 5406 18 . . . cord-010092-uftc8inx 5407 1 Detailed detailed JJ cord-010092-uftc8inx 5407 2 data datum NNS cord-010092-uftc8inx 5407 3 are be VBP cord-010092-uftc8inx 5407 4 presented present VBN cord-010092-uftc8inx 5407 5 in in IN cord-010092-uftc8inx 5407 6 Table Table NNP cord-010092-uftc8inx 5407 7 1 1 CD cord-010092-uftc8inx 5407 8 . . . cord-010092-uftc8inx 5408 1 Student student NN cord-010092-uftc8inx 5408 2 's 's POS cord-010092-uftc8inx 5408 3 t t NN cord-010092-uftc8inx 5408 4 - - HYPH cord-010092-uftc8inx 5408 5 test test NN cord-010092-uftc8inx 5408 6 for for IN cord-010092-uftc8inx 5408 7 unrelated unrelated JJ cord-010092-uftc8inx 5408 8 sets set NNS cord-010092-uftc8inx 5408 9 was be VBD cord-010092-uftc8inx 5408 10 used use VBN cord-010092-uftc8inx 5408 11 for for IN cord-010092-uftc8inx 5408 12 statistical statistical JJ cord-010092-uftc8inx 5408 13 analysis analysis NN cord-010092-uftc8inx 5408 14 of of IN cord-010092-uftc8inx 5408 15 the the DT cord-010092-uftc8inx 5408 16 data datum NNS cord-010092-uftc8inx 5408 17 . . . cord-010092-uftc8inx 5409 1 A a DT cord-010092-uftc8inx 5409 2 value value NN cord-010092-uftc8inx 5409 3 P p NN cord-010092-uftc8inx 5409 4 of of IN cord-010092-uftc8inx 5409 5 less less JJR cord-010092-uftc8inx 5409 6 than than IN cord-010092-uftc8inx 5409 7 0.05 0.05 CD cord-010092-uftc8inx 5409 8 was be VBD cord-010092-uftc8inx 5409 9 considered consider VBN cord-010092-uftc8inx 5409 10 as as RB cord-010092-uftc8inx 5409 11 significant significant JJ cord-010092-uftc8inx 5409 12 . . . cord-010092-uftc8inx 5410 1 Results result NNS cord-010092-uftc8inx 5410 2 : : : cord-010092-uftc8inx 5411 1 The the DT cord-010092-uftc8inx 5411 2 data datum NNS cord-010092-uftc8inx 5411 3 obtained obtain VBD cord-010092-uftc8inx 5411 4 showed show VBD cord-010092-uftc8inx 5411 5 significant significant JJ cord-010092-uftc8inx 5411 6 difference difference NN cord-010092-uftc8inx 5411 7 ( ( -LRB- cord-010092-uftc8inx 5411 8 P p NN cord-010092-uftc8inx 5411 9 < < XX cord-010092-uftc8inx 5411 10 0.01 0.01 CD cord-010092-uftc8inx 5411 11 ) ) -RRB- cord-010092-uftc8inx 5411 12 between between IN cord-010092-uftc8inx 5411 13 average average JJ cord-010092-uftc8inx 5411 14 number number NN cord-010092-uftc8inx 5411 15 of of IN cord-010092-uftc8inx 5411 16 platelets platelet NNS cord-010092-uftc8inx 5411 17 collected collect VBN cord-010092-uftc8inx 5411 18 on on IN cord-010092-uftc8inx 5411 19 Trima Trima NNP cord-010092-uftc8inx 5411 20 Accel Accel NNP cord-010092-uftc8inx 5411 21 ( ( -LRB- cord-010092-uftc8inx 5411 22 6.3 6.3 CD cord-010092-uftc8inx 5411 23 AE AE NNP cord-010092-uftc8inx 5411 24 1.06 1.06 CD cord-010092-uftc8inx 5411 25 9 9 CD cord-010092-uftc8inx 5411 26 10 10 CD cord-010092-uftc8inx 5411 27 11 11 CD cord-010092-uftc8inx 5411 28 /L /L . cord-010092-uftc8inx 5411 29 ) ) -RRB- cord-010092-uftc8inx 5411 30 and and CC cord-010092-uftc8inx 5411 31 on on IN cord-010092-uftc8inx 5411 32 MCS MCS NNP cord-010092-uftc8inx 5411 33 + + CC cord-010092-uftc8inx 5411 34 9000 9000 CD cord-010092-uftc8inx 5411 35 ( ( -LRB- cord-010092-uftc8inx 5411 36 5.09 5.09 CD cord-010092-uftc8inx 5411 37 AE AE NNP cord-010092-uftc8inx 5411 38 0.78 0.78 CD cord-010092-uftc8inx 5411 39 9 9 CD cord-010092-uftc8inx 5411 40 10 10 CD cord-010092-uftc8inx 5411 41 11 11 CD cord-010092-uftc8inx 5411 42 /L /L . cord-010092-uftc8inx 5411 43 ) ) -RRB- cord-010092-uftc8inx 5411 44 . . . cord-010092-uftc8inx 5412 1 While while IN cord-010092-uftc8inx 5412 2 cost cost NN cord-010092-uftc8inx 5412 3 of of IN cord-010092-uftc8inx 5412 4 consumables consumable NNS cord-010092-uftc8inx 5412 5 are be VBP cord-010092-uftc8inx 5412 6 comparable comparable JJ cord-010092-uftc8inx 5412 7 , , , cord-010092-uftc8inx 5412 8 Trima Trima NNP cord-010092-uftc8inx 5412 9 Accel Accel NNP cord-010092-uftc8inx 5412 10 demonstrated demonstrate VBD cord-010092-uftc8inx 5412 11 23.7 23.7 CD cord-010092-uftc8inx 5412 12 % % NN cord-010092-uftc8inx 5412 13 higher high JJR cord-010092-uftc8inx 5412 14 efficiency efficiency NN cord-010092-uftc8inx 5412 15 . . . cord-010092-uftc8inx 5413 1 Procedure procedure NN cord-010092-uftc8inx 5413 2 duration duration NN cord-010092-uftc8inx 5413 3 also also RB cord-010092-uftc8inx 5413 4 was be VBD cord-010092-uftc8inx 5413 5 comparable comparable JJ cord-010092-uftc8inx 5413 6 and and CC cord-010092-uftc8inx 5413 7 averaged average VBD cord-010092-uftc8inx 5413 8 within within IN cord-010092-uftc8inx 5413 9 94 94 CD cord-010092-uftc8inx 5413 10 min min NN cord-010092-uftc8inx 5413 11 for for IN cord-010092-uftc8inx 5413 12 both both DT cord-010092-uftc8inx 5413 13 devices device NNS cord-010092-uftc8inx 5413 14 . . . cord-010092-uftc8inx 5414 1 Detailed detailed JJ cord-010092-uftc8inx 5414 2 data datum NNS cord-010092-uftc8inx 5414 3 are be VBP cord-010092-uftc8inx 5414 4 presented present VBN cord-010092-uftc8inx 5414 5 in in IN cord-010092-uftc8inx 5414 6 Table Table NNP cord-010092-uftc8inx 5414 7 2 2 CD cord-010092-uftc8inx 5414 8 . . . cord-010092-uftc8inx 5415 1 It -PRON- PRP cord-010092-uftc8inx 5415 2 is be VBZ cord-010092-uftc8inx 5415 3 crucial crucial JJ cord-010092-uftc8inx 5415 4 to to TO cord-010092-uftc8inx 5415 5 mention mention VB cord-010092-uftc8inx 5415 6 that that IN cord-010092-uftc8inx 5415 7 proportion proportion NN cord-010092-uftc8inx 5415 8 of of IN cord-010092-uftc8inx 5415 9 Trima Trima NNP cord-010092-uftc8inx 5415 10 Accel Accel NNP cord-010092-uftc8inx 5415 11 's 's POS cord-010092-uftc8inx 5415 12 donations donation NNS cord-010092-uftc8inx 5415 13 was be VBD cord-010092-uftc8inx 5415 14 significantly significantly RB cord-010092-uftc8inx 5415 15 increased increase VBN cord-010092-uftc8inx 5415 16 in in IN cord-010092-uftc8inx 5415 17 NRCH NRCH NNP cord-010092-uftc8inx 5415 18 during during IN cord-010092-uftc8inx 5415 19 2018 2018 CD cord-010092-uftc8inx 5415 20 and and CC cord-010092-uftc8inx 5415 21 reached reach VBD cord-010092-uftc8inx 5415 22 56 56 CD cord-010092-uftc8inx 5415 23 , , , cord-010092-uftc8inx 5415 24 7 7 CD cord-010092-uftc8inx 5415 25 % % NN cord-010092-uftc8inx 5415 26 in in IN cord-010092-uftc8inx 5415 27 total total JJ cord-010092-uftc8inx 5415 28 ( ( -LRB- cord-010092-uftc8inx 5415 29 2017 2017 CD cord-010092-uftc8inx 5415 30 - - SYM cord-010092-uftc8inx 5415 31 19.4 19.4 CD cord-010092-uftc8inx 5415 32 % % NN cord-010092-uftc8inx 5415 33 ) ) -RRB- cord-010092-uftc8inx 5415 34 . . . cord-010092-uftc8inx 5416 1 A a DT cord-010092-uftc8inx 5416 2 flexible flexible JJ cord-010092-uftc8inx 5416 3 usage usage NN cord-010092-uftc8inx 5416 4 of of IN cord-010092-uftc8inx 5416 5 Trima Trima NNP cord-010092-uftc8inx 5416 6 Accel Accel NNP cord-010092-uftc8inx 5416 7 's 's POS cord-010092-uftc8inx 5416 8 consumables consumable NNS cord-010092-uftc8inx 5416 9 for for IN cord-010092-uftc8inx 5416 10 different different JJ cord-010092-uftc8inx 5416 11 procedures procedure NNS cord-010092-uftc8inx 5416 12 ( ( -LRB- cord-010092-uftc8inx 5416 13 regular regular JJ cord-010092-uftc8inx 5416 14 platelet platelet NN cord-010092-uftc8inx 5416 15 collection collection NN cord-010092-uftc8inx 5416 16 and and CC cord-010092-uftc8inx 5416 17 collection collection NN cord-010092-uftc8inx 5416 18 in in IN cord-010092-uftc8inx 5416 19 PAS pas NN cord-010092-uftc8inx 5416 20 ) ) -RRB- cord-010092-uftc8inx 5416 21 allowed allow VBN cord-010092-uftc8inx 5416 22 to to TO cord-010092-uftc8inx 5416 23 change change VB cord-010092-uftc8inx 5416 24 the the DT cord-010092-uftc8inx 5416 25 PAS pas NN cord-010092-uftc8inx 5416 26 / / SYM cord-010092-uftc8inx 5416 27 regular regular JJ cord-010092-uftc8inx 5416 28 platelets platelet NNS cord-010092-uftc8inx 5416 29 collection collection NN cord-010092-uftc8inx 5416 30 ratio ratio NN cord-010092-uftc8inx 5416 31 from from IN cord-010092-uftc8inx 5416 32 7.64 7.64 CD cord-010092-uftc8inx 5416 33 % % NN cord-010092-uftc8inx 5416 34 up up IN cord-010092-uftc8inx 5416 35 to to TO cord-010092-uftc8inx 5416 36 43.7 43.7 CD cord-010092-uftc8inx 5416 37 % % NN cord-010092-uftc8inx 5416 38 . . . cord-010092-uftc8inx 5417 1 Summary Summary NNP cord-010092-uftc8inx 5417 2 / / SYM cord-010092-uftc8inx 5417 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 5417 4 : : : cord-010092-uftc8inx 5418 1 Obtained obtain VBN cord-010092-uftc8inx 5418 2 results result NNS cord-010092-uftc8inx 5418 3 proved prove VBD cord-010092-uftc8inx 5418 4 the the DT cord-010092-uftc8inx 5418 5 effectiveness effectiveness NN cord-010092-uftc8inx 5418 6 of of IN cord-010092-uftc8inx 5418 7 the the DT cord-010092-uftc8inx 5418 8 Trima Trima NNP cord-010092-uftc8inx 5418 9 Accel Accel NNP cord-010092-uftc8inx 5418 10 's 's POS cord-010092-uftc8inx 5418 11 use use NN cord-010092-uftc8inx 5418 12 for for IN cord-010092-uftc8inx 5418 13 platelets platelet NNS cord-010092-uftc8inx 5418 14 concentrates concentrate VBZ cord-010092-uftc8inx 5418 15 production production NN cord-010092-uftc8inx 5418 16 . . . cord-010092-uftc8inx 5419 1 It -PRON- PRP cord-010092-uftc8inx 5419 2 allowed allow VBD cord-010092-uftc8inx 5419 3 to to TO cord-010092-uftc8inx 5419 4 increase increase VB cord-010092-uftc8inx 5419 5 the the DT cord-010092-uftc8inx 5419 6 average average JJ cord-010092-uftc8inx 5419 7 count count NN cord-010092-uftc8inx 5419 8 of of IN cord-010092-uftc8inx 5419 9 platelets platelet NNS cord-010092-uftc8inx 5419 10 obtained obtain VBN cord-010092-uftc8inx 5419 11 for for IN cord-010092-uftc8inx 5419 12 one one CD cord-010092-uftc8inx 5419 13 procedure procedure NN cord-010092-uftc8inx 5419 14 by by IN cord-010092-uftc8inx 5419 15 23.7 23.7 CD cord-010092-uftc8inx 5419 16 % % NN cord-010092-uftc8inx 5419 17 compared compare VBN cord-010092-uftc8inx 5419 18 to to IN cord-010092-uftc8inx 5419 19 MCS MCS NNP cord-010092-uftc8inx 5419 20 + + CC cord-010092-uftc8inx 5419 21 9000 9000 CD cord-010092-uftc8inx 5419 22 while while IN cord-010092-uftc8inx 5419 23 the the DT cord-010092-uftc8inx 5419 24 cost cost NN cord-010092-uftc8inx 5419 25 of of IN cord-010092-uftc8inx 5419 26 consumables consumable NNS cord-010092-uftc8inx 5419 27 and and CC cord-010092-uftc8inx 5419 28 procedure procedure NN cord-010092-uftc8inx 5419 29 duration duration NN cord-010092-uftc8inx 5419 30 are be VBP cord-010092-uftc8inx 5419 31 comparable comparable JJ cord-010092-uftc8inx 5419 32 . . . cord-010092-uftc8inx 5420 1 The the DT cord-010092-uftc8inx 5420 2 donor donor NN cord-010092-uftc8inx 5420 3 's 's POS cord-010092-uftc8inx 5420 4 comfort comfort NN cord-010092-uftc8inx 5420 5 during during IN cord-010092-uftc8inx 5420 6 procedure procedure NN cord-010092-uftc8inx 5420 7 did do VBD cord-010092-uftc8inx 5420 8 not not RB cord-010092-uftc8inx 5420 9 affect affect VB cord-010092-uftc8inx 5420 10 either either RB cord-010092-uftc8inx 5420 11 . . . cord-010092-uftc8inx 5421 1 In in IN cord-010092-uftc8inx 5421 2 long long JJ cord-010092-uftc8inx 5421 3 terms term NNS cord-010092-uftc8inx 5421 4 increasing increase VBG cord-010092-uftc8inx 5421 5 of of IN cord-010092-uftc8inx 5421 6 number number NN cord-010092-uftc8inx 5421 7 of of IN cord-010092-uftc8inx 5421 8 platelets platelet NNS cord-010092-uftc8inx 5421 9 collected collect VBN cord-010092-uftc8inx 5421 10 is be VBZ cord-010092-uftc8inx 5421 11 reducing reduce VBG cord-010092-uftc8inx 5421 12 the the DT cord-010092-uftc8inx 5421 13 cost cost NN cord-010092-uftc8inx 5421 14 of of IN cord-010092-uftc8inx 5421 15 platelet platelet NN cord-010092-uftc8inx 5421 16 concentrates concentrate VBZ cord-010092-uftc8inx 5421 17 production production NN cord-010092-uftc8inx 5421 18 . . . cord-010092-uftc8inx 5422 1 Abstract Abstract NNP cord-010092-uftc8inx 5422 2 withdrawn withdraw VBN cord-010092-uftc8inx 5422 3 . . . cord-010092-uftc8inx 5423 1 Background background NN cord-010092-uftc8inx 5423 2 : : : cord-010092-uftc8inx 5424 1 Apheresis Apheresis NNP cord-010092-uftc8inx 5424 2 collected collect VBD cord-010092-uftc8inx 5424 3 platelet platelet NN cord-010092-uftc8inx 5424 4 concentrate concentrate NN cord-010092-uftc8inx 5424 5 is be VBZ cord-010092-uftc8inx 5424 6 preferable preferable JJ cord-010092-uftc8inx 5424 7 in in IN cord-010092-uftc8inx 5424 8 terms term NNS cord-010092-uftc8inx 5424 9 of of IN cord-010092-uftc8inx 5424 10 reducing reduce VBG cord-010092-uftc8inx 5424 11 the the DT cord-010092-uftc8inx 5424 12 risks risk NNS cord-010092-uftc8inx 5424 13 of of IN cord-010092-uftc8inx 5424 14 adverse adverse JJ cord-010092-uftc8inx 5424 15 reactions reaction NNS cord-010092-uftc8inx 5424 16 in in IN cord-010092-uftc8inx 5424 17 platelet platelet NN cord-010092-uftc8inx 5424 18 transfusion transfusion NN cord-010092-uftc8inx 5424 19 when when WRB cord-010092-uftc8inx 5424 20 compared compare VBN cord-010092-uftc8inx 5424 21 to to IN cord-010092-uftc8inx 5424 22 random random JJ cord-010092-uftc8inx 5424 23 donor donor NN cord-010092-uftc8inx 5424 24 platelet platelet NN cord-010092-uftc8inx 5424 25 concentrates concentrate VBZ cord-010092-uftc8inx 5424 26 . . . cord-010092-uftc8inx 5425 1 Aims aim VBZ cord-010092-uftc8inx 5425 2 : : : cord-010092-uftc8inx 5426 1 The the DT cord-010092-uftc8inx 5426 2 aim aim NN cord-010092-uftc8inx 5426 3 of of IN cord-010092-uftc8inx 5426 4 our -PRON- PRP$ cord-010092-uftc8inx 5426 5 study study NN cord-010092-uftc8inx 5426 6 is be VBZ cord-010092-uftc8inx 5426 7 to to TO cord-010092-uftc8inx 5426 8 present present VB cord-010092-uftc8inx 5426 9 our -PRON- PRP$ cord-010092-uftc8inx 5426 10 experience experience NN cord-010092-uftc8inx 5426 11 in in IN cord-010092-uftc8inx 5426 12 collection collection NN cord-010092-uftc8inx 5426 13 donation donation NN cord-010092-uftc8inx 5426 14 of of IN cord-010092-uftc8inx 5426 15 single single JJ cord-010092-uftc8inx 5426 16 donor donor NN cord-010092-uftc8inx 5426 17 platelets platelet NNS cord-010092-uftc8inx 5426 18 with with IN cord-010092-uftc8inx 5426 19 apheresis apheresis NN cord-010092-uftc8inx 5426 20 . . . cord-010092-uftc8inx 5427 1 Methods method NNS cord-010092-uftc8inx 5427 2 : : : cord-010092-uftc8inx 5427 3 This this DT cord-010092-uftc8inx 5427 4 is be VBZ cord-010092-uftc8inx 5427 5 a a DT cord-010092-uftc8inx 5427 6 retrospective retrospective JJ cord-010092-uftc8inx 5427 7 study study NN cord-010092-uftc8inx 5427 8 performed perform VBN cord-010092-uftc8inx 5427 9 in in IN cord-010092-uftc8inx 5427 10 the the DT cord-010092-uftc8inx 5427 11 Institute Institute NNP cord-010092-uftc8inx 5427 12 for for IN cord-010092-uftc8inx 5427 13 Transfusion Transfusion NNP cord-010092-uftc8inx 5427 14 Medicine Medicine NNP cord-010092-uftc8inx 5427 15 from from IN cord-010092-uftc8inx 5427 16 2010 2010 CD cord-010092-uftc8inx 5427 17 till till IN cord-010092-uftc8inx 5427 18 2019 2019 CD cord-010092-uftc8inx 5427 19 . . . cord-010092-uftc8inx 5428 1 All all DT cord-010092-uftc8inx 5428 2 donors donor NNS cord-010092-uftc8inx 5428 3 were be VBD cord-010092-uftc8inx 5428 4 fully fully RB cord-010092-uftc8inx 5428 5 informed inform VBN cord-010092-uftc8inx 5428 6 on on IN cord-010092-uftc8inx 5428 7 the the DT cord-010092-uftc8inx 5428 8 donation donation NN cord-010092-uftc8inx 5428 9 procedure procedure NN cord-010092-uftc8inx 5428 10 and and CC cord-010092-uftc8inx 5428 11 signed sign VBD cord-010092-uftc8inx 5428 12 an an DT cord-010092-uftc8inx 5428 13 informed informed JJ cord-010092-uftc8inx 5428 14 consent consent NN cord-010092-uftc8inx 5428 15 for for IN cord-010092-uftc8inx 5428 16 donation donation NN cord-010092-uftc8inx 5428 17 . . . cord-010092-uftc8inx 5429 1 The the DT cord-010092-uftc8inx 5429 2 optimal optimal JJ cord-010092-uftc8inx 5429 3 platelet platelet NN cord-010092-uftc8inx 5429 4 count count NN cord-010092-uftc8inx 5429 5 that that IN cord-010092-uftc8inx 5429 6 we -PRON- PRP cord-010092-uftc8inx 5429 7 want want VBP cord-010092-uftc8inx 5429 8 to to TO cord-010092-uftc8inx 5429 9 achieve achieve VB cord-010092-uftc8inx 5429 10 was be VBD cord-010092-uftc8inx 5429 11 ≥ ≥ NNP cord-010092-uftc8inx 5429 12 3.0 3.0 CD cord-010092-uftc8inx 5429 13 9 9 CD cord-010092-uftc8inx 5429 14 10 10 CD cord-010092-uftc8inx 5429 15 11 11 CD cord-010092-uftc8inx 5429 16 equal equal JJ cord-010092-uftc8inx 5429 17 to to IN cord-010092-uftc8inx 5429 18 12 12 CD cord-010092-uftc8inx 5429 19 random random JJ cord-010092-uftc8inx 5429 20 donor donor NN cord-010092-uftc8inx 5429 21 platelet platelet NN cord-010092-uftc8inx 5429 22 doses dose NNS cord-010092-uftc8inx 5429 23 . . . cord-010092-uftc8inx 5430 1 Minimum minimum JJ cord-010092-uftc8inx 5430 2 preapheresis preapheresis NN cord-010092-uftc8inx 5430 3 platelet platelet NN cord-010092-uftc8inx 5430 4 count count NN cord-010092-uftc8inx 5430 5 in in IN cord-010092-uftc8inx 5430 6 donors donor NNS cord-010092-uftc8inx 5430 7 requested request VBD cord-010092-uftc8inx 5430 8 to to TO cord-010092-uftc8inx 5430 9 start start VB cord-010092-uftc8inx 5430 10 the the DT cord-010092-uftc8inx 5430 11 apheresis apheresis NN cord-010092-uftc8inx 5430 12 collection collection NN cord-010092-uftc8inx 5430 13 was be VBD cord-010092-uftc8inx 5430 14 150.000 150.000 CD cord-010092-uftc8inx 5431 1 /ll /ll NFP cord-010092-uftc8inx 5431 2 . . . cord-010092-uftc8inx 5432 1 Platelet platelet NN cord-010092-uftc8inx 5432 2 collection collection NN cord-010092-uftc8inx 5432 3 was be VBD cord-010092-uftc8inx 5432 4 performed perform VBN cord-010092-uftc8inx 5432 5 using use VBG cord-010092-uftc8inx 5432 6 flow flow NN cord-010092-uftc8inx 5432 7 cell cell NN cord-010092-uftc8inx 5432 8 separators separator NNS cord-010092-uftc8inx 5432 9 Haemonetics Haemonetics NNP cord-010092-uftc8inx 5432 10 MCS+ MCS+ NNP cord-010092-uftc8inx 5432 11 and and CC cord-010092-uftc8inx 5432 12 Trima Trima NNP cord-010092-uftc8inx 5432 13 Accel Accel NNP cord-010092-uftc8inx 5432 14 . . . cord-010092-uftc8inx 5433 1 Acid Acid NNP cord-010092-uftc8inx 5433 2 Citrate Citrate NNP cord-010092-uftc8inx 5434 1 Dextrose dextrose NN cord-010092-uftc8inx 5434 2 formula formula NN cord-010092-uftc8inx 5434 3 A A NNP cord-010092-uftc8inx 5434 4 was be VBD cord-010092-uftc8inx 5434 5 used use VBN cord-010092-uftc8inx 5434 6 for for IN cord-010092-uftc8inx 5434 7 anticoagulation anticoagulation NN cord-010092-uftc8inx 5434 8 . . . cord-010092-uftc8inx 5435 1 Median median JJ cord-010092-uftc8inx 5435 2 precollection precollection NN cord-010092-uftc8inx 5435 3 platelet platelet NN cord-010092-uftc8inx 5435 4 count count NN cord-010092-uftc8inx 5435 5 of of IN cord-010092-uftc8inx 5435 6 donors donor NNS cord-010092-uftc8inx 5435 7 was be VBD cord-010092-uftc8inx 5436 1 273.000 273.000 CD cord-010092-uftc8inx 5436 2 / / SYM cord-010092-uftc8inx 5436 3 ll ll UH cord-010092-uftc8inx 5436 4 , , , cord-010092-uftc8inx 5436 5 with with IN cord-010092-uftc8inx 5436 6 range range NN cord-010092-uftc8inx 5436 7 from from IN cord-010092-uftc8inx 5436 8 182.000 182.000 CD cord-010092-uftc8inx 5436 9 / / SYM cord-010092-uftc8inx 5436 10 ll ll VBP cord-010092-uftc8inx 5436 11 to to IN cord-010092-uftc8inx 5436 12 397.000 397.000 CD cord-010092-uftc8inx 5436 13 / / SYM cord-010092-uftc8inx 5436 14 ll ll VB cord-010092-uftc8inx 5436 15 . . . cord-010092-uftc8inx 5437 1 Male male NN cord-010092-uftc8inx 5437 2 were be VBD cord-010092-uftc8inx 5437 3 77 77 CD cord-010092-uftc8inx 5437 4 % % NN cord-010092-uftc8inx 5437 5 of of IN cord-010092-uftc8inx 5437 6 the the DT cord-010092-uftc8inx 5437 7 donors donor NNS cord-010092-uftc8inx 5437 8 and and CC cord-010092-uftc8inx 5437 9 females female NNS cord-010092-uftc8inx 5437 10 were be VBD cord-010092-uftc8inx 5437 11 23 23 CD cord-010092-uftc8inx 5437 12 % % NN cord-010092-uftc8inx 5437 13 . . . cord-010092-uftc8inx 5438 1 The the DT cord-010092-uftc8inx 5438 2 single single JJ cord-010092-uftc8inx 5438 3 procedure procedure NN cord-010092-uftc8inx 5438 4 usually usually RB cord-010092-uftc8inx 5438 5 took take VBD cord-010092-uftc8inx 5438 6 45 45 CD cord-010092-uftc8inx 5438 7 - - SYM cord-010092-uftc8inx 5438 8 70 70 CD cord-010092-uftc8inx 5438 9 min min NN cord-010092-uftc8inx 5438 10 . . . cord-010092-uftc8inx 5439 1 The the DT cord-010092-uftc8inx 5439 2 median median JJ cord-010092-uftc8inx 5439 3 platelet platelet NN cord-010092-uftc8inx 5439 4 count count NN cord-010092-uftc8inx 5439 5 collected collect VBD cord-010092-uftc8inx 5439 6 was be VBD cord-010092-uftc8inx 5439 7 4.0 4.0 CD cord-010092-uftc8inx 5439 8 9 9 CD cord-010092-uftc8inx 5439 9 10 10 CD cord-010092-uftc8inx 5439 10 11 11 CD cord-010092-uftc8inx 5439 11 , , , cord-010092-uftc8inx 5440 1 range range NNP cord-010092-uftc8inx 5440 2 2 2 CD cord-010092-uftc8inx 5440 3 - - SYM cord-010092-uftc8inx 5440 4 6.5 6.5 CD cord-010092-uftc8inx 5440 5 9 9 CD cord-010092-uftc8inx 5440 6 10 10 CD cord-010092-uftc8inx 5440 7 11 11 CD cord-010092-uftc8inx 5440 8 . . . cord-010092-uftc8inx 5441 1 The the DT cord-010092-uftc8inx 5441 2 median median NN cord-010092-uftc8inx 5441 3 processed process VBN cord-010092-uftc8inx 5441 4 blood blood NN cord-010092-uftc8inx 5441 5 volume volume NN cord-010092-uftc8inx 5441 6 was be VBD cord-010092-uftc8inx 5441 7 3215 3215 CD cord-010092-uftc8inx 5441 8 ml ml NNS cord-010092-uftc8inx 5441 9 and and CC cord-010092-uftc8inx 5441 10 median median NN cord-010092-uftc8inx 5442 1 used use VBN cord-010092-uftc8inx 5442 2 ACD ACD NNP cord-010092-uftc8inx 5442 3 - - HYPH cord-010092-uftc8inx 5442 4 A A NNP cord-010092-uftc8inx 5442 5 was be VBD cord-010092-uftc8inx 5442 6 352 352 CD cord-010092-uftc8inx 5442 7 ml ml NN cord-010092-uftc8inx 5442 8 . . . cord-010092-uftc8inx 5443 1 Mean mean JJ cord-010092-uftc8inx 5443 2 total total JJ cord-010092-uftc8inx 5443 3 volume volume NN cord-010092-uftc8inx 5443 4 of of IN cord-010092-uftc8inx 5443 5 collected collect VBN cord-010092-uftc8inx 5443 6 product product NN cord-010092-uftc8inx 5443 7 was be VBD cord-010092-uftc8inx 5443 8 312 312 CD cord-010092-uftc8inx 5443 9 ml ml NN cord-010092-uftc8inx 5443 10 . . . cord-010092-uftc8inx 5444 1 The the DT cord-010092-uftc8inx 5444 2 adverse adverse JJ cord-010092-uftc8inx 5444 3 effects effect NNS cord-010092-uftc8inx 5444 4 included include VBD cord-010092-uftc8inx 5444 5 vein vein NN cord-010092-uftc8inx 5444 6 perforation perforation NN cord-010092-uftc8inx 5444 7 and and CC cord-010092-uftc8inx 5444 8 the the DT cord-010092-uftc8inx 5444 9 numbness numbness NN cord-010092-uftc8inx 5444 10 of of IN cord-010092-uftc8inx 5444 11 the the DT cord-010092-uftc8inx 5444 12 extremities extremity NNS cord-010092-uftc8inx 5444 13 as as IN cord-010092-uftc8inx 5444 14 reaction reaction NN cord-010092-uftc8inx 5444 15 of of IN cord-010092-uftc8inx 5444 16 ACD ACD NNP cord-010092-uftc8inx 5444 17 - - HYPH cord-010092-uftc8inx 5444 18 A a NN cord-010092-uftc8inx 5444 19 ( ( -LRB- cord-010092-uftc8inx 5444 20 hypocalcemia hypocalcemia NN cord-010092-uftc8inx 5444 21 ) ) -RRB- cord-010092-uftc8inx 5444 22 , , , cord-010092-uftc8inx 5444 23 which which WDT cord-010092-uftc8inx 5444 24 occur occur VBP cord-010092-uftc8inx 5444 25 rarely rarely RB cord-010092-uftc8inx 5444 26 and and CC cord-010092-uftc8inx 5444 27 was be VBD cord-010092-uftc8inx 5444 28 very very RB cord-010092-uftc8inx 5444 29 mild mild JJ cord-010092-uftc8inx 5444 30 . . . cord-010092-uftc8inx 5445 1 Summary Summary NNP cord-010092-uftc8inx 5445 2 / / SYM cord-010092-uftc8inx 5445 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 5445 4 : : : cord-010092-uftc8inx 5446 1 The the DT cord-010092-uftc8inx 5446 2 collected collect VBN cord-010092-uftc8inx 5446 3 platelet platelet NN cord-010092-uftc8inx 5446 4 count count NN cord-010092-uftc8inx 5446 5 was be VBD cord-010092-uftc8inx 5446 6 more more JJR cord-010092-uftc8inx 5446 7 than than IN cord-010092-uftc8inx 5446 8 the the DT cord-010092-uftc8inx 5446 9 wanted want VBN cord-010092-uftc8inx 5446 10 optimum optimum JJ cord-010092-uftc8inx 5446 11 platelet platelet NN cord-010092-uftc8inx 5446 12 count count NN cord-010092-uftc8inx 5446 13 . . . cord-010092-uftc8inx 5447 1 The the DT cord-010092-uftc8inx 5447 2 number number NN cord-010092-uftc8inx 5447 3 of of IN cord-010092-uftc8inx 5447 4 apheresis apheresis NN cord-010092-uftc8inx 5447 5 donors donor NNS cord-010092-uftc8inx 5447 6 is be VBZ cord-010092-uftc8inx 5447 7 increasing increase VBG cord-010092-uftc8inx 5447 8 and and CC cord-010092-uftc8inx 5447 9 we -PRON- PRP cord-010092-uftc8inx 5447 10 are be VBP cord-010092-uftc8inx 5447 11 working work VBG cord-010092-uftc8inx 5447 12 on on IN cord-010092-uftc8inx 5447 13 expanding expand VBG cord-010092-uftc8inx 5447 14 our -PRON- PRP$ cord-010092-uftc8inx 5447 15 Voluntary Voluntary NNP cord-010092-uftc8inx 5447 16 Platelet Platelet NNP cord-010092-uftc8inx 5447 17 Donors Donors NNPS cord-010092-uftc8inx 5447 18 Registry Registry NNP cord-010092-uftc8inx 5447 19 and and CC cord-010092-uftc8inx 5447 20 increasing increase VBG cord-010092-uftc8inx 5447 21 the the DT cord-010092-uftc8inx 5447 22 number number NN cord-010092-uftc8inx 5447 23 of of IN cord-010092-uftc8inx 5447 24 typed type VBN cord-010092-uftc8inx 5447 25 donors donor NNS cord-010092-uftc8inx 5447 26 in in IN cord-010092-uftc8inx 5447 27 the the DT cord-010092-uftc8inx 5447 28 Registry Registry NNP cord-010092-uftc8inx 5447 29 . . . cord-010092-uftc8inx 5448 1 Background background NN cord-010092-uftc8inx 5448 2 : : : cord-010092-uftc8inx 5449 1 To to TO cord-010092-uftc8inx 5449 2 determine determine VB cord-010092-uftc8inx 5449 3 value value NN cord-010092-uftc8inx 5449 4 of of IN cord-010092-uftc8inx 5449 5 hemoglobin hemoglobin NN cord-010092-uftc8inx 5449 6 in in IN cord-010092-uftc8inx 5449 7 blood blood NN cord-010092-uftc8inx 5449 8 donors donor NNS cord-010092-uftc8inx 5449 9 , , , cord-010092-uftc8inx 5449 10 there there EX cord-010092-uftc8inx 5449 11 are be VBP cord-010092-uftc8inx 5449 12 some some DT cord-010092-uftc8inx 5449 13 tools tool NNS cord-010092-uftc8inx 5449 14 or or CC cord-010092-uftc8inx 5449 15 methods method NNS cord-010092-uftc8inx 5449 16 used use VBN cord-010092-uftc8inx 5449 17 , , , cord-010092-uftc8inx 5449 18 such such JJ cord-010092-uftc8inx 5449 19 as as IN cord-010092-uftc8inx 5449 20 : : : cord-010092-uftc8inx 5449 21 Cyanmethemoglobin Cyanmethemoglobin NNP cord-010092-uftc8inx 5449 22 method method NN cord-010092-uftc8inx 5449 23 that that WDT cord-010092-uftc8inx 5449 24 can can MD cord-010092-uftc8inx 5449 25 detect detect VB cord-010092-uftc8inx 5449 26 of of IN cord-010092-uftc8inx 5449 27 hemoglobin hemoglobin NN cord-010092-uftc8inx 5449 28 quantitative quantitative JJ cord-010092-uftc8inx 5449 29 and and CC cord-010092-uftc8inx 5449 30 methods method NNS cord-010092-uftc8inx 5449 31 Cupric Cupric NNP cord-010092-uftc8inx 5449 32 Sulfate Sulfate NNP cord-010092-uftc8inx 5449 33 solutions solution NNS cord-010092-uftc8inx 5449 34 ( ( -LRB- cord-010092-uftc8inx 5449 35 CuSO4 CuSO4 NNP cord-010092-uftc8inx 5449 36 ) ) -RRB- cord-010092-uftc8inx 5449 37 can can MD cord-010092-uftc8inx 5449 38 detect detect VB cord-010092-uftc8inx 5449 39 of of IN cord-010092-uftc8inx 5449 40 hemoglobin hemoglobin NN cord-010092-uftc8inx 5449 41 qualitative qualitative JJ cord-010092-uftc8inx 5449 42 . . . cord-010092-uftc8inx 5450 1 According accord VBG cord-010092-uftc8inx 5450 2 to to IN cord-010092-uftc8inx 5450 3 WHO who WP cord-010092-uftc8inx 5450 4 ( ( -LRB- cord-010092-uftc8inx 5450 5 World World NNP cord-010092-uftc8inx 5450 6 Health Health NNP cord-010092-uftc8inx 5450 7 Organization Organization NNP cord-010092-uftc8inx 5450 8 ) ) -RRB- cord-010092-uftc8inx 5450 9 to to TO cord-010092-uftc8inx 5450 10 determine determine VB cord-010092-uftc8inx 5450 11 the the DT cord-010092-uftc8inx 5450 12 level level NN cord-010092-uftc8inx 5450 13 of of IN cord-010092-uftc8inx 5450 14 hemoglobin hemoglobin NN cord-010092-uftc8inx 5450 15 in in IN cord-010092-uftc8inx 5450 16 blood blood NN cord-010092-uftc8inx 5450 17 donors donor NNS cord-010092-uftc8inx 5450 18 enough enough RB cord-010092-uftc8inx 5450 19 used use VBD cord-010092-uftc8inx 5450 20 CuSO4 cuso4 NN cord-010092-uftc8inx 5450 21 solutions solution NNS cord-010092-uftc8inx 5450 22 with with IN cord-010092-uftc8inx 5450 23 specific specific JJ cord-010092-uftc8inx 5450 24 weight weight NN cord-010092-uftc8inx 5450 25 ( ( -LRB- cord-010092-uftc8inx 5450 26 y y NN cord-010092-uftc8inx 5450 27 ) ) -RRB- cord-010092-uftc8inx 5450 28 1.053 1.053 CD cord-010092-uftc8inx 5450 29 can can MD cord-010092-uftc8inx 5450 30 to to TO cord-010092-uftc8inx 5450 31 detect detect VB cord-010092-uftc8inx 5450 32 value value NN cord-010092-uftc8inx 5450 33 of of IN cord-010092-uftc8inx 5450 34 hemoglobin hemoglobin NN cord-010092-uftc8inx 5450 35 above above IN cord-010092-uftc8inx 5450 36 or or CC cord-010092-uftc8inx 5450 37 same same JJ cord-010092-uftc8inx 5450 38 with with IN cord-010092-uftc8inx 5450 39 12.5 12.5 CD cord-010092-uftc8inx 5450 40 gr gr NNP cord-010092-uftc8inx 5450 41 / / SYM cord-010092-uftc8inx 5450 42 dL. dL. NNP cord-010092-uftc8inx 5451 1 But but CC cord-010092-uftc8inx 5451 2 , , , cord-010092-uftc8inx 5451 3 CuSO4 cuso4 NN cord-010092-uftc8inx 5451 4 solution solution NN cord-010092-uftc8inx 5451 5 specific specific JJ cord-010092-uftc8inx 5451 6 weight weight NN cord-010092-uftc8inx 5451 7 1.053 1.053 CD cord-010092-uftc8inx 5451 8 can can MD cord-010092-uftc8inx 5451 9 not not RB cord-010092-uftc8inx 5451 10 to to TO cord-010092-uftc8inx 5451 11 detect detect VB cord-010092-uftc8inx 5451 12 and and CC cord-010092-uftc8inx 5451 13 elimination elimination NN cord-010092-uftc8inx 5451 14 value value NN cord-010092-uftc8inx 5451 15 of of IN cord-010092-uftc8inx 5451 16 hemoglobin hemoglobin NN cord-010092-uftc8inx 5451 17 above above IN cord-010092-uftc8inx 5451 18 17 17 CD cord-010092-uftc8inx 5451 19 gr gr NNP cord-010092-uftc8inx 5451 20 / / SYM cord-010092-uftc8inx 5451 21 dL dl NN cord-010092-uftc8inx 5451 22 or or CC cord-010092-uftc8inx 5451 23 polycythemia polycythemia NN cord-010092-uftc8inx 5451 24 sick sick JJ cord-010092-uftc8inx 5451 25 . . . cord-010092-uftc8inx 5452 1 Because because IN cord-010092-uftc8inx 5452 2 it -PRON- PRP cord-010092-uftc8inx 5452 3 , , , cord-010092-uftc8inx 5452 4 Central Central NNP cord-010092-uftc8inx 5452 5 Blood Blood NNP cord-010092-uftc8inx 5452 6 Transfusion Transfusion NNP cord-010092-uftc8inx 5452 7 Unit Unit NNP cord-010092-uftc8inx 5452 8 ( ( -LRB- cord-010092-uftc8inx 5452 9 UTDP UTDP NNP cord-010092-uftc8inx 5452 10 ) ) -RRB- cord-010092-uftc8inx 5452 11 as as IN cord-010092-uftc8inx 5452 12 the the DT cord-010092-uftc8inx 5452 13 central central NN cord-010092-uftc8inx 5452 14 of of IN cord-010092-uftc8inx 5452 15 blood blood NN cord-010092-uftc8inx 5452 16 service service NN cord-010092-uftc8inx 5452 17 in in IN cord-010092-uftc8inx 5452 18 Indonesia Indonesia NNP cord-010092-uftc8inx 5452 19 to to TO cord-010092-uftc8inx 5452 20 manufacture manufacture VB cord-010092-uftc8inx 5452 21 Cupric Cupric NNP cord-010092-uftc8inx 5452 22 Sulfate Sulfate NNP cord-010092-uftc8inx 5452 23 solution solution NN cord-010092-uftc8inx 5452 24 ( ( -LRB- cord-010092-uftc8inx 5452 25 CuSO4 CuSO4 NNP cord-010092-uftc8inx 5452 26 ) ) -RRB- cord-010092-uftc8inx 5452 27 with with IN cord-010092-uftc8inx 5452 28 a a DT cord-010092-uftc8inx 5452 29 specific specific JJ cord-010092-uftc8inx 5452 30 weight weight NN cord-010092-uftc8inx 5452 31 ( ( -LRB- cord-010092-uftc8inx 5452 32 y y NN cord-010092-uftc8inx 5452 33 ) ) -RRB- cord-010092-uftc8inx 5452 34 1062 1062 CD cord-010092-uftc8inx 5452 35 to to TO cord-010092-uftc8inx 5452 36 detect detect VB cord-010092-uftc8inx 5452 37 value value NN cord-010092-uftc8inx 5452 38 of of IN cord-010092-uftc8inx 5452 39 hemoglobin hemoglobin NN cord-010092-uftc8inx 5452 40 below below IN cord-010092-uftc8inx 5452 41 17gr/ 17gr/ CD cord-010092-uftc8inx 5452 42 dL dl NN cord-010092-uftc8inx 5452 43 and and CC cord-010092-uftc8inx 5452 44 determine determine VB cord-010092-uftc8inx 5452 45 value value NN cord-010092-uftc8inx 5452 46 of of IN cord-010092-uftc8inx 5452 47 hemoglobin hemoglobin NN cord-010092-uftc8inx 5452 48 above above IN cord-010092-uftc8inx 5452 49 17 17 CD cord-010092-uftc8inx 5452 50 gr gr NNP cord-010092-uftc8inx 5452 51 / / SYM cord-010092-uftc8inx 5452 52 dL. dL. NNP cord-010092-uftc8inx 5453 1 Because because IN cord-010092-uftc8inx 5453 2 it -PRON- PRP cord-010092-uftc8inx 5453 3 , , , cord-010092-uftc8inx 5453 4 do do VB cord-010092-uftc8inx 5453 5 the the DT cord-010092-uftc8inx 5453 6 testing testing NN cord-010092-uftc8inx 5453 7 the the DT cord-010092-uftc8inx 5453 8 accuracy accuracy NN cord-010092-uftc8inx 5453 9 of of IN cord-010092-uftc8inx 5453 10 the the DT cord-010092-uftc8inx 5453 11 solution solution NN cord-010092-uftc8inx 5453 12 Cupric Cupric NNP cord-010092-uftc8inx 5453 13 Sulfate Sulfate NNP cord-010092-uftc8inx 5453 14 in in IN cord-010092-uftc8inx 5453 15 detecting detect VBG cord-010092-uftc8inx 5453 16 and and CC cord-010092-uftc8inx 5453 17 eliminating eliminate VBG cord-010092-uftc8inx 5453 18 donor donor NN cord-010092-uftc8inx 5453 19 with with IN cord-010092-uftc8inx 5453 20 value value NN cord-010092-uftc8inx 5453 21 of of IN cord-010092-uftc8inx 5453 22 hemoglobin hemoglobin NN cord-010092-uftc8inx 5453 23 above above IN cord-010092-uftc8inx 5453 24 17gr 17gr NN cord-010092-uftc8inx 5453 25 / / SYM cord-010092-uftc8inx 5453 26 dL dl NN cord-010092-uftc8inx 5453 27 with with IN cord-010092-uftc8inx 5453 28 the the DT cord-010092-uftc8inx 5453 29 test test NN cord-010092-uftc8inx 5453 30 of of IN cord-010092-uftc8inx 5453 31 35 35 CD cord-010092-uftc8inx 5453 32 samples sample NNS cord-010092-uftc8inx 5453 33 . . . cord-010092-uftc8inx 5454 1 Aims aim VBZ cord-010092-uftc8inx 5454 2 : : : cord-010092-uftc8inx 5454 3 To to TO cord-010092-uftc8inx 5454 4 determine determine VB cord-010092-uftc8inx 5454 5 accuracy accuracy NN cord-010092-uftc8inx 5454 6 and and CC cord-010092-uftc8inx 5454 7 effectiveness effectiveness NN cord-010092-uftc8inx 5454 8 by by IN cord-010092-uftc8inx 5454 9 Blood Blood NNP cord-010092-uftc8inx 5454 10 Donors Donors NNPS cord-010092-uftc8inx 5454 11 Unit Unit NNP cord-010092-uftc8inx 5454 12 in in IN cord-010092-uftc8inx 5454 13 Indonesia Indonesia NNP cord-010092-uftc8inx 5454 14 Red Red NNP cord-010092-uftc8inx 5454 15 Cross Cross NNP cord-010092-uftc8inx 5454 16 to to TO cord-010092-uftc8inx 5454 17 use use VB cord-010092-uftc8inx 5454 18 CuSO4 cuso4 NN cord-010092-uftc8inx 5454 19 solution solution NN cord-010092-uftc8inx 5454 20 with with IN cord-010092-uftc8inx 5454 21 specific specific JJ cord-010092-uftc8inx 5454 22 weight weight NN cord-010092-uftc8inx 5454 23 1.062 1.062 CD cord-010092-uftc8inx 5454 24 in in IN cord-010092-uftc8inx 5454 25 to to TO cord-010092-uftc8inx 5454 26 detect detect VB cord-010092-uftc8inx 5454 27 and and CC cord-010092-uftc8inx 5454 28 elimination elimination NN cord-010092-uftc8inx 5454 29 value value NN cord-010092-uftc8inx 5454 30 of of IN cord-010092-uftc8inx 5454 31 hemoglobin hemoglobin NN cord-010092-uftc8inx 5454 32 donors donor NNS cord-010092-uftc8inx 5454 33 above above IN cord-010092-uftc8inx 5454 34 17 17 CD cord-010092-uftc8inx 5454 35 gr gr NNP cord-010092-uftc8inx 5454 36 / / SYM cord-010092-uftc8inx 5454 37 dL. dL. NNS cord-010092-uftc8inx 5454 38 Methods method NNS cord-010092-uftc8inx 5454 39 : : : cord-010092-uftc8inx 5454 40 Used use VBN cord-010092-uftc8inx 5454 41 The the DT cord-010092-uftc8inx 5454 42 method method NN cord-010092-uftc8inx 5454 43 Cyanmethemoglobin Cyanmethemoglobin NNP cord-010092-uftc8inx 5454 44 and and CC cord-010092-uftc8inx 5454 45 CuSO4 CuSO4 NNP cord-010092-uftc8inx 5454 46 ( ( -LRB- cord-010092-uftc8inx 5454 47 y y NNP cord-010092-uftc8inx 5454 48 ) ) -RRB- cord-010092-uftc8inx 5454 49 1.062 1.062 CD cord-010092-uftc8inx 5454 50 determination determination NN cord-010092-uftc8inx 5454 51 value value NN cord-010092-uftc8inx 5454 52 of of IN cord-010092-uftc8inx 5454 53 hemoglobin hemoglobin NN cord-010092-uftc8inx 5454 54 donor donor NN cord-010092-uftc8inx 5454 55 . . . cord-010092-uftc8inx 5455 1 Test test NN cord-010092-uftc8inx 5455 2 results result NNS cord-010092-uftc8inx 5455 3 were be VBD cord-010092-uftc8inx 5455 4 analyzed analyze VBN cord-010092-uftc8inx 5455 5 with with IN cord-010092-uftc8inx 5455 6 SPSS SPSS NNP cord-010092-uftc8inx 5455 7 software software NN cord-010092-uftc8inx 5455 8 version version NN cord-010092-uftc8inx 5455 9 23 23 CD cord-010092-uftc8inx 5455 10 using use VBG cord-010092-uftc8inx 5455 11 nonparametric nonparametric JJ cord-010092-uftc8inx 5455 12 analysis analysis NN cord-010092-uftc8inx 5455 13 Wilcoxon Wilcoxon NNP cord-010092-uftc8inx 5455 14 test test NN cord-010092-uftc8inx 5455 15 . . . cord-010092-uftc8inx 5456 1 Results result NNS cord-010092-uftc8inx 5456 2 : : : cord-010092-uftc8inx 5457 1 This this DT cord-010092-uftc8inx 5457 2 research research NN cord-010092-uftc8inx 5457 3 testing test VBG cord-010092-uftc8inx 5457 4 the the DT cord-010092-uftc8inx 5457 5 accuracy accuracy NN cord-010092-uftc8inx 5457 6 and and CC cord-010092-uftc8inx 5457 7 effectiveness effectiveness NN cord-010092-uftc8inx 5457 8 of of IN cord-010092-uftc8inx 5457 9 using use VBG cord-010092-uftc8inx 5457 10 a a DT cord-010092-uftc8inx 5457 11 CuSO4 cuso4 NN cord-010092-uftc8inx 5457 12 solution solution NN cord-010092-uftc8inx 5457 13 with with IN cord-010092-uftc8inx 5457 14 specific specific JJ cord-010092-uftc8inx 5457 15 weight weight NN cord-010092-uftc8inx 5457 16 ( ( -LRB- cord-010092-uftc8inx 5457 17 y y NN cord-010092-uftc8inx 5457 18 ) ) -RRB- cord-010092-uftc8inx 5457 19 : : : cord-010092-uftc8inx 5457 20 1.062 1.062 CD cord-010092-uftc8inx 5457 21 in in IN cord-010092-uftc8inx 5457 22 detecting detect VBG cord-010092-uftc8inx 5457 23 and and CC cord-010092-uftc8inx 5457 24 eliminating eliminate VBG cord-010092-uftc8inx 5457 25 hemoglobin hemoglobin NN cord-010092-uftc8inx 5457 26 value value NN cord-010092-uftc8inx 5457 27 donors donor NNS cord-010092-uftc8inx 5457 28 above above IN cord-010092-uftc8inx 5457 29 17gr 17gr NNP cord-010092-uftc8inx 5458 1 /dL. /dL. . cord-010092-uftc8inx 5459 1 From from IN cord-010092-uftc8inx 5459 2 data datum NNS cord-010092-uftc8inx 5459 3 processing processing NN cord-010092-uftc8inx 5459 4 using use VBG cord-010092-uftc8inx 5459 5 SPSS SPSS NNP cord-010092-uftc8inx 5459 6 with with IN cord-010092-uftc8inx 5459 7 the the DT cord-010092-uftc8inx 5459 8 Wilcoxon Wilcoxon NNP cord-010092-uftc8inx 5459 9 test test NN cord-010092-uftc8inx 5459 10 P p NN cord-010092-uftc8inx 5459 11 value value NN cord-010092-uftc8inx 5459 12 0.02 0.02 CD cord-010092-uftc8inx 5459 13 . . . cord-010092-uftc8inx 5460 1 Summary Summary NNP cord-010092-uftc8inx 5460 2 / / SYM cord-010092-uftc8inx 5460 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 5460 4 : : : cord-010092-uftc8inx 5461 1 It -PRON- PRP cord-010092-uftc8inx 5461 2 was be VBD cord-010092-uftc8inx 5461 3 found find VBN cord-010092-uftc8inx 5461 4 that that IN cord-010092-uftc8inx 5461 5 the the DT cord-010092-uftc8inx 5461 6 CuSO4 CuSO4 NNP cord-010092-uftc8inx 5461 7 solution solution NN cord-010092-uftc8inx 5461 8 ( ( -LRB- cord-010092-uftc8inx 5461 9 y y NN cord-010092-uftc8inx 5461 10 ) ) -RRB- cord-010092-uftc8inx 5461 11 : : : cord-010092-uftc8inx 5461 12 1062 1062 CD cord-010092-uftc8inx 5461 13 can can MD cord-010092-uftc8inx 5461 14 detect detect VB cord-010092-uftc8inx 5461 15 hemoglobins hemoglobin NNS cord-010092-uftc8inx 5461 16 value value NN cord-010092-uftc8inx 5461 17 above above IN cord-010092-uftc8inx 5461 18 17gr 17gr NN cord-010092-uftc8inx 5461 19 / / SYM cord-010092-uftc8inx 5461 20 dL dl NN cord-010092-uftc8inx 5461 21 and and CC cord-010092-uftc8inx 5461 22 more more RBR cord-010092-uftc8inx 5461 23 effective effective JJ cord-010092-uftc8inx 5461 24 in in IN cord-010092-uftc8inx 5461 25 checking check VBG cord-010092-uftc8inx 5461 26 the the DT cord-010092-uftc8inx 5461 27 hemoglobin hemoglobin NN cord-010092-uftc8inx 5461 28 in in IN cord-010092-uftc8inx 5461 29 blood blood NN cord-010092-uftc8inx 5461 30 donors donor NNS cord-010092-uftc8inx 5461 31 . . . cord-010092-uftc8inx 5462 1 It -PRON- PRP cord-010092-uftc8inx 5462 2 can can MD cord-010092-uftc8inx 5462 3 be be VB cord-010092-uftc8inx 5462 4 seen see VBN cord-010092-uftc8inx 5462 5 from from IN cord-010092-uftc8inx 5462 6 the the DT cord-010092-uftc8inx 5462 7 data data NN cord-010092-uftc8inx 5462 8 processing processing NN cord-010092-uftc8inx 5462 9 with with IN cord-010092-uftc8inx 5462 10 SPSS SPSS NNP cord-010092-uftc8inx 5462 11 version version NN cord-010092-uftc8inx 5462 12 23 23 CD cord-010092-uftc8inx 5462 13 with with IN cord-010092-uftc8inx 5462 14 the the DT cord-010092-uftc8inx 5462 15 Wilcoxon Wilcoxon NNP cord-010092-uftc8inx 5462 16 test test NN cord-010092-uftc8inx 5462 17 P p NN cord-010092-uftc8inx 5462 18 value value NN cord-010092-uftc8inx 5462 19 < < XX cord-010092-uftc8inx 5462 20 0.05 0.05 CD cord-010092-uftc8inx 5462 21 . . . cord-010092-uftc8inx 5463 1 It -PRON- PRP cord-010092-uftc8inx 5463 2 is be VBZ cord-010092-uftc8inx 5463 3 important important JJ cord-010092-uftc8inx 5463 4 to to TO cord-010092-uftc8inx 5463 5 monitor monitor VB cord-010092-uftc8inx 5463 6 the the DT cord-010092-uftc8inx 5463 7 precise precise JJ cord-010092-uftc8inx 5463 8 course course NN cord-010092-uftc8inx 5463 9 by by IN cord-010092-uftc8inx 5463 10 which which WDT cord-010092-uftc8inx 5463 11 repeated repeat VBD cord-010092-uftc8inx 5463 12 blood blood NN cord-010092-uftc8inx 5463 13 donation donation NN cord-010092-uftc8inx 5463 14 affects affect VBZ cord-010092-uftc8inx 5463 15 Hb Hb NNP cord-010092-uftc8inx 5463 16 and and CC cord-010092-uftc8inx 5463 17 the the DT cord-010092-uftc8inx 5463 18 probability probability NN cord-010092-uftc8inx 5463 19 of of IN cord-010092-uftc8inx 5463 20 low low JJ cord-010092-uftc8inx 5463 21 Hb Hb NNP cord-010092-uftc8inx 5463 22 deferral deferral NN cord-010092-uftc8inx 5463 23 . . . cord-010092-uftc8inx 5464 1 Zinc Zinc NNP cord-010092-uftc8inx 5464 2 protoporphyrin protoporphyrin NNP cord-010092-uftc8inx 5464 3 ( ( -LRB- cord-010092-uftc8inx 5464 4 ZPP ZPP NNP cord-010092-uftc8inx 5464 5 ) ) -RRB- cord-010092-uftc8inx 5464 6 is be VBZ cord-010092-uftc8inx 5464 7 a a DT cord-010092-uftc8inx 5464 8 functional functional JJ cord-010092-uftc8inx 5464 9 indicator indicator NN cord-010092-uftc8inx 5464 10 of of IN cord-010092-uftc8inx 5464 11 body body NN cord-010092-uftc8inx 5464 12 iron iron NN cord-010092-uftc8inx 5464 13 levels level NNS cord-010092-uftc8inx 5464 14 and and CC cord-010092-uftc8inx 5464 15 is be VBZ cord-010092-uftc8inx 5464 16 hypothesized hypothesize VBN cord-010092-uftc8inx 5464 17 to to TO cord-010092-uftc8inx 5464 18 predict predict VB cord-010092-uftc8inx 5464 19 Hb Hb NNP cord-010092-uftc8inx 5464 20 levels level NNS cord-010092-uftc8inx 5464 21 among among IN cord-010092-uftc8inx 5464 22 blood blood NN cord-010092-uftc8inx 5464 23 donors donor NNS cord-010092-uftc8inx 5464 24 . . . cord-010092-uftc8inx 5465 1 Advanced advanced JJ cord-010092-uftc8inx 5465 2 statistical statistical JJ cord-010092-uftc8inx 5465 3 methods method NNS cord-010092-uftc8inx 5465 4 are be VBP cord-010092-uftc8inx 5465 5 necessary necessary JJ cord-010092-uftc8inx 5465 6 to to TO cord-010092-uftc8inx 5465 7 properly properly RB cord-010092-uftc8inx 5465 8 analyze analyze VB cord-010092-uftc8inx 5465 9 the the DT cord-010092-uftc8inx 5465 10 longitudinal longitudinal JJ cord-010092-uftc8inx 5465 11 associations association NNS cord-010092-uftc8inx 5465 12 between between IN cord-010092-uftc8inx 5465 13 ZPP ZPP NNP cord-010092-uftc8inx 5465 14 and and CC cord-010092-uftc8inx 5465 15 Hb Hb NNP cord-010092-uftc8inx 5465 16 in in IN cord-010092-uftc8inx 5465 17 data datum NNS cord-010092-uftc8inx 5465 18 with with IN cord-010092-uftc8inx 5465 19 repeated repeat VBN cord-010092-uftc8inx 5465 20 donations donation NNS cord-010092-uftc8inx 5465 21 per per IN cord-010092-uftc8inx 5465 22 donor donor NN cord-010092-uftc8inx 5465 23 . . . cord-010092-uftc8inx 5466 1 Aims aim VBZ cord-010092-uftc8inx 5466 2 : : : cord-010092-uftc8inx 5467 1 To to TO cord-010092-uftc8inx 5467 2 determine determine VB cord-010092-uftc8inx 5467 3 whether whether IN cord-010092-uftc8inx 5467 4 predictions prediction NNS cord-010092-uftc8inx 5467 5 of of IN cord-010092-uftc8inx 5467 6 future future JJ cord-010092-uftc8inx 5467 7 Hb Hb NNP cord-010092-uftc8inx 5467 8 levels level NNS cord-010092-uftc8inx 5467 9 using use VBG cord-010092-uftc8inx 5467 10 current current JJ cord-010092-uftc8inx 5467 11 Hb Hb NNP cord-010092-uftc8inx 5467 12 levels level NNS cord-010092-uftc8inx 5467 13 can can MD cord-010092-uftc8inx 5467 14 be be VB cord-010092-uftc8inx 5467 15 improved improve VBN cord-010092-uftc8inx 5467 16 by by IN cord-010092-uftc8inx 5467 17 taking take VBG cord-010092-uftc8inx 5467 18 ZPP ZPP NNP cord-010092-uftc8inx 5467 19 levels level NNS cord-010092-uftc8inx 5467 20 into into IN cord-010092-uftc8inx 5467 21 account account NN cord-010092-uftc8inx 5467 22 , , , cord-010092-uftc8inx 5467 23 and and CC cord-010092-uftc8inx 5467 24 to to TO cord-010092-uftc8inx 5467 25 illustrate illustrate VB cord-010092-uftc8inx 5467 26 the the DT cord-010092-uftc8inx 5467 27 use use NN cord-010092-uftc8inx 5467 28 of of IN cord-010092-uftc8inx 5467 29 statistical statistical JJ cord-010092-uftc8inx 5467 30 models model NNS cord-010092-uftc8inx 5467 31 for for IN cord-010092-uftc8inx 5467 32 repeated repeat VBN cord-010092-uftc8inx 5467 33 measurements measurement NNS cord-010092-uftc8inx 5467 34 of of IN cord-010092-uftc8inx 5467 35 blood blood NN cord-010092-uftc8inx 5467 36 donors donor NNS cord-010092-uftc8inx 5467 37 . . . cord-010092-uftc8inx 5468 1 Methods method NNS cord-010092-uftc8inx 5468 2 : : : cord-010092-uftc8inx 5469 1 We -PRON- PRP cord-010092-uftc8inx 5469 2 used use VBD cord-010092-uftc8inx 5469 3 data datum NNS cord-010092-uftc8inx 5469 4 from from IN cord-010092-uftc8inx 5469 5 the the DT cord-010092-uftc8inx 5469 6 ZPP ZPP NNP cord-010092-uftc8inx 5469 7 and and CC cord-010092-uftc8inx 5469 8 Iron Iron NNP cord-010092-uftc8inx 5469 9 in in IN cord-010092-uftc8inx 5469 10 the the DT cord-010092-uftc8inx 5469 11 Netherlands Netherlands NNP cord-010092-uftc8inx 5469 12 Cohort Cohort NNP cord-010092-uftc8inx 5469 13 ( ( -LRB- cord-010092-uftc8inx 5469 14 ZINC ZINC NNP cord-010092-uftc8inx 5469 15 ) ) -RRB- cord-010092-uftc8inx 5469 16 study study NN cord-010092-uftc8inx 5469 17 . . . cord-010092-uftc8inx 5470 1 We -PRON- PRP cord-010092-uftc8inx 5470 2 identified identify VBD cord-010092-uftc8inx 5470 3 previous previous JJ cord-010092-uftc8inx 5470 4 ZPP ZPP NNP cord-010092-uftc8inx 5470 5 levels level NNS cord-010092-uftc8inx 5470 6 ( ( -LRB- cord-010092-uftc8inx 5470 7 log log NN cord-010092-uftc8inx 5470 8 - - HYPH cord-010092-uftc8inx 5470 9 transformed transform VBN cord-010092-uftc8inx 5470 10 ) ) -RRB- cord-010092-uftc8inx 5470 11 as as IN cord-010092-uftc8inx 5470 12 the the DT cord-010092-uftc8inx 5470 13 main main JJ cord-010092-uftc8inx 5470 14 predictor predictor NN cord-010092-uftc8inx 5470 15 and and CC cord-010092-uftc8inx 5470 16 adjusted adjust VBN cord-010092-uftc8inx 5470 17 for for IN cord-010092-uftc8inx 5470 18 previous previous JJ cord-010092-uftc8inx 5470 19 Hb Hb NNP cord-010092-uftc8inx 5470 20 level level NN cord-010092-uftc8inx 5470 21 , , , cord-010092-uftc8inx 5470 22 age age NN cord-010092-uftc8inx 5470 23 , , , cord-010092-uftc8inx 5470 24 day day NN cord-010092-uftc8inx 5470 25 and and CC cord-010092-uftc8inx 5470 26 time time NN cord-010092-uftc8inx 5470 27 of of IN cord-010092-uftc8inx 5470 28 donation donation NN cord-010092-uftc8inx 5470 29 , , , cord-010092-uftc8inx 5470 30 donation donation NN cord-010092-uftc8inx 5470 31 history history NN cord-010092-uftc8inx 5470 32 , , , cord-010092-uftc8inx 5470 33 BMI BMI NNP cord-010092-uftc8inx 5470 34 , , , cord-010092-uftc8inx 5470 35 blood blood NN cord-010092-uftc8inx 5470 36 volume volume NN cord-010092-uftc8inx 5470 37 and and CC cord-010092-uftc8inx 5470 38 blood blood NN cord-010092-uftc8inx 5470 39 pressure pressure NN cord-010092-uftc8inx 5470 40 . . . cord-010092-uftc8inx 5471 1 We -PRON- PRP cord-010092-uftc8inx 5471 2 used use VBD cord-010092-uftc8inx 5471 3 linear linear JJ cord-010092-uftc8inx 5471 4 mixed mixed JJ cord-010092-uftc8inx 5471 5 models model NNS cord-010092-uftc8inx 5471 6 , , , cord-010092-uftc8inx 5471 7 which which WDT cord-010092-uftc8inx 5471 8 take take VBP cord-010092-uftc8inx 5471 9 into into IN cord-010092-uftc8inx 5471 10 account account NN cord-010092-uftc8inx 5471 11 missing miss VBG cord-010092-uftc8inx 5471 12 data datum NNS cord-010092-uftc8inx 5471 13 in in IN cord-010092-uftc8inx 5471 14 the the DT cord-010092-uftc8inx 5471 15 outcome outcome NN cord-010092-uftc8inx 5471 16 and and CC cord-010092-uftc8inx 5471 17 associations association NNS cord-010092-uftc8inx 5471 18 between between IN cord-010092-uftc8inx 5471 19 repeated repeat VBN cord-010092-uftc8inx 5471 20 measurements measurement NNS cord-010092-uftc8inx 5471 21 , , , cord-010092-uftc8inx 5471 22 to to TO cord-010092-uftc8inx 5471 23 investigate investigate VB cord-010092-uftc8inx 5471 24 the the DT cord-010092-uftc8inx 5471 25 longitudinal longitudinal JJ cord-010092-uftc8inx 5471 26 association association NN cord-010092-uftc8inx 5471 27 between between IN cord-010092-uftc8inx 5471 28 previous previous JJ cord-010092-uftc8inx 5471 29 ZPP ZPP NNP cord-010092-uftc8inx 5471 30 and and CC cord-010092-uftc8inx 5471 31 current current JJ cord-010092-uftc8inx 5471 32 Hb Hb NNP cord-010092-uftc8inx 5471 33 levels level NNS cord-010092-uftc8inx 5471 34 . . . cord-010092-uftc8inx 5472 1 The the DT cord-010092-uftc8inx 5472 2 longitudinal longitudinal JJ cord-010092-uftc8inx 5472 3 analysis analysis NN cord-010092-uftc8inx 5472 4 with with IN cord-010092-uftc8inx 5472 5 linear linear JJ cord-010092-uftc8inx 5472 6 mixed mixed JJ cord-010092-uftc8inx 5472 7 models model NNS cord-010092-uftc8inx 5472 8 was be VBD cord-010092-uftc8inx 5472 9 contrasted contrast VBN cord-010092-uftc8inx 5472 10 with with IN cord-010092-uftc8inx 5472 11 a a DT cord-010092-uftc8inx 5472 12 simpler simple JJR cord-010092-uftc8inx 5472 13 analysis analysis NN cord-010092-uftc8inx 5472 14 based base VBN cord-010092-uftc8inx 5472 15 on on IN cord-010092-uftc8inx 5472 16 the the DT cord-010092-uftc8inx 5472 17 area area NN cord-010092-uftc8inx 5472 18 under under IN cord-010092-uftc8inx 5472 19 the the DT cord-010092-uftc8inx 5472 20 receiver receiver NN cord-010092-uftc8inx 5472 21 - - HYPH cord-010092-uftc8inx 5472 22 operating operating NN cord-010092-uftc8inx 5472 23 - - HYPH cord-010092-uftc8inx 5472 24 characteristic characteristic NN cord-010092-uftc8inx 5472 25 ( ( -LRB- cord-010092-uftc8inx 5472 26 ROC ROC NNP cord-010092-uftc8inx 5472 27 ) ) -RRB- cord-010092-uftc8inx 5472 28 curve curve NN cord-010092-uftc8inx 5472 29 for for IN cord-010092-uftc8inx 5472 30 the the DT cord-010092-uftc8inx 5472 31 probability probability NN cord-010092-uftc8inx 5472 32 of of IN cord-010092-uftc8inx 5472 33 low low JJ cord-010092-uftc8inx 5472 34 Hb Hb NNP cord-010092-uftc8inx 5472 35 deferral deferral NN cord-010092-uftc8inx 5472 36 . . . cord-010092-uftc8inx 5473 1 Results result NNS cord-010092-uftc8inx 5473 2 : : : cord-010092-uftc8inx 5474 1 In in IN cord-010092-uftc8inx 5474 2 total total NN cord-010092-uftc8inx 5474 3 , , , cord-010092-uftc8inx 5474 4 8194 8194 CD cord-010092-uftc8inx 5474 5 whole whole JJ cord-010092-uftc8inx 5474 6 blood blood NN cord-010092-uftc8inx 5474 7 donors donor NNS cord-010092-uftc8inx 5474 8 ( ( -LRB- cord-010092-uftc8inx 5474 9 20,864 20,864 CD cord-010092-uftc8inx 5474 10 whole whole JJ cord-010092-uftc8inx 5474 11 - - HYPH cord-010092-uftc8inx 5474 12 blood blood NN cord-010092-uftc8inx 5474 13 donations donation NNS cord-010092-uftc8inx 5474 14 ) ) -RRB- cord-010092-uftc8inx 5474 15 were be VBD cord-010092-uftc8inx 5474 16 included include VBN cord-010092-uftc8inx 5474 17 in in IN cord-010092-uftc8inx 5474 18 the the DT cord-010092-uftc8inx 5474 19 ZINC zinc NN cord-010092-uftc8inx 5474 20 study study NN cord-010092-uftc8inx 5474 21 , , , cord-010092-uftc8inx 5474 22 63 63 CD cord-010092-uftc8inx 5474 23 % % NN cord-010092-uftc8inx 5474 24 being be VBG cord-010092-uftc8inx 5474 25 female female JJ cord-010092-uftc8inx 5474 26 donors donor NNS cord-010092-uftc8inx 5474 27 . . . cord-010092-uftc8inx 5475 1 Previous previous JJ cord-010092-uftc8inx 5475 2 ZPP ZPP NNP cord-010092-uftc8inx 5475 3 showed show VBD cord-010092-uftc8inx 5475 4 a a DT cord-010092-uftc8inx 5475 5 statistically statistically RB cord-010092-uftc8inx 5475 6 significant significant JJ cord-010092-uftc8inx 5475 7 association association NN cord-010092-uftc8inx 5475 8 ( ( -LRB- cord-010092-uftc8inx 5475 9 P p NN cord-010092-uftc8inx 5475 10 < < XX cord-010092-uftc8inx 5475 11 0.001 0.001 CD cord-010092-uftc8inx 5475 12 ) ) -RRB- cord-010092-uftc8inx 5475 13 with with IN cord-010092-uftc8inx 5475 14 Hb Hb NNP cord-010092-uftc8inx 5475 15 levels level NNS cord-010092-uftc8inx 5475 16 in in IN cord-010092-uftc8inx 5475 17 females female NNS cord-010092-uftc8inx 5475 18 , , , cord-010092-uftc8inx 5475 19 but but CC cord-010092-uftc8inx 5475 20 the the DT cord-010092-uftc8inx 5475 21 size size NN cord-010092-uftc8inx 5475 22 of of IN cord-010092-uftc8inx 5475 23 the the DT cord-010092-uftc8inx 5475 24 association association NN cord-010092-uftc8inx 5475 25 was be VBD cord-010092-uftc8inx 5475 26 quite quite RB cord-010092-uftc8inx 5475 27 small small JJ cord-010092-uftc8inx 5475 28 ( ( -LRB- cord-010092-uftc8inx 5475 29 regression regression NN cord-010092-uftc8inx 5475 30 coefficient coefficient NN cord-010092-uftc8inx 5475 31 , , , cord-010092-uftc8inx 5475 32 B b NN cord-010092-uftc8inx 5475 33 = = SYM cord-010092-uftc8inx 5475 34 À0.17 À0.17 NNPS cord-010092-uftc8inx 5475 35 , , , cord-010092-uftc8inx 5475 36 95 95 CD cord-010092-uftc8inx 5475 37 % % NN cord-010092-uftc8inx 5475 38 confidence confidence NN cord-010092-uftc8inx 5475 39 interval interval NN cord-010092-uftc8inx 5475 40 À0.22 À0.22 NNP cord-010092-uftc8inx 5475 41 to to IN cord-010092-uftc8inx 5475 42 À0.11 À0.11 NNP cord-010092-uftc8inx 5475 43 ) ) -RRB- cord-010092-uftc8inx 5475 44 . . . cord-010092-uftc8inx 5476 1 The the DT cord-010092-uftc8inx 5476 2 same same JJ cord-010092-uftc8inx 5476 3 was be VBD cord-010092-uftc8inx 5476 4 true true JJ cord-010092-uftc8inx 5476 5 for for IN cord-010092-uftc8inx 5476 6 males male NNS cord-010092-uftc8inx 5476 7 , , , cord-010092-uftc8inx 5476 8 but but CC cord-010092-uftc8inx 5476 9 the the DT cord-010092-uftc8inx 5476 10 size size NN cord-010092-uftc8inx 5476 11 of of IN cord-010092-uftc8inx 5476 12 the the DT cord-010092-uftc8inx 5476 13 association association NN cord-010092-uftc8inx 5476 14 was be VBD cord-010092-uftc8inx 5476 15 even even RB cord-010092-uftc8inx 5476 16 smaller small JJR cord-010092-uftc8inx 5476 17 . . . cord-010092-uftc8inx 5477 1 Blood blood NN cord-010092-uftc8inx 5477 2 volume volume NN cord-010092-uftc8inx 5477 3 and and CC cord-010092-uftc8inx 5477 4 age age NN cord-010092-uftc8inx 5477 5 for for IN cord-010092-uftc8inx 5477 6 women woman NNS cord-010092-uftc8inx 5477 7 were be VBD cord-010092-uftc8inx 5477 8 significant significant JJ cord-010092-uftc8inx 5477 9 secondary secondary JJ cord-010092-uftc8inx 5477 10 predictor predictor NN cord-010092-uftc8inx 5477 11 variables variable NNS cord-010092-uftc8inx 5477 12 ; ; : cord-010092-uftc8inx 5477 13 blood blood NN cord-010092-uftc8inx 5477 14 volume volume NN cord-010092-uftc8inx 5477 15 , , , cord-010092-uftc8inx 5477 16 age age NN cord-010092-uftc8inx 5477 17 and and CC cord-010092-uftc8inx 5477 18 donation donation NN cord-010092-uftc8inx 5477 19 interval interval NN cord-010092-uftc8inx 5477 20 for for IN cord-010092-uftc8inx 5477 21 men man NNS cord-010092-uftc8inx 5477 22 . . . cord-010092-uftc8inx 5478 1 By by IN cord-010092-uftc8inx 5478 2 comparison comparison NN cord-010092-uftc8inx 5478 3 , , , cord-010092-uftc8inx 5478 4 the the DT cord-010092-uftc8inx 5478 5 ROC ROC NNP cord-010092-uftc8inx 5478 6 analyses analysis NNS cord-010092-uftc8inx 5478 7 showed show VBD cord-010092-uftc8inx 5478 8 relatively relatively RB cord-010092-uftc8inx 5478 9 larger large JJR cord-010092-uftc8inx 5478 10 , , , cord-010092-uftc8inx 5478 11 but but CC cord-010092-uftc8inx 5478 12 less less RBR cord-010092-uftc8inx 5478 13 statistically statistically RB cord-010092-uftc8inx 5478 14 significant significant JJ cord-010092-uftc8inx 5478 15 predictive predictive JJ cord-010092-uftc8inx 5478 16 effects effect NNS cord-010092-uftc8inx 5478 17 of of IN cord-010092-uftc8inx 5478 18 ZPP ZPP NNP cord-010092-uftc8inx 5478 19 on on IN cord-010092-uftc8inx 5478 20 Hb Hb NNP cord-010092-uftc8inx 5478 21 . . . cord-010092-uftc8inx 5479 1 Summary Summary NNP cord-010092-uftc8inx 5479 2 / / SYM cord-010092-uftc8inx 5479 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 5479 4 : : : cord-010092-uftc8inx 5480 1 ZPP ZPP NNP cord-010092-uftc8inx 5480 2 is be VBZ cord-010092-uftc8inx 5480 3 a a DT cord-010092-uftc8inx 5480 4 statistically statistically RB cord-010092-uftc8inx 5480 5 significant significant JJ cord-010092-uftc8inx 5480 6 predictor predictor NN cord-010092-uftc8inx 5480 7 of of IN cord-010092-uftc8inx 5480 8 Hb Hb NNP cord-010092-uftc8inx 5480 9 levels level NNS cord-010092-uftc8inx 5480 10 , , , cord-010092-uftc8inx 5480 11 but but CC cord-010092-uftc8inx 5480 12 the the DT cord-010092-uftc8inx 5480 13 size size NN cord-010092-uftc8inx 5480 14 of of IN cord-010092-uftc8inx 5480 15 the the DT cord-010092-uftc8inx 5480 16 effect effect NN cord-010092-uftc8inx 5480 17 after after IN cord-010092-uftc8inx 5480 18 adjustment adjustment NN cord-010092-uftc8inx 5480 19 for for IN cord-010092-uftc8inx 5480 20 previous previous JJ cord-010092-uftc8inx 5480 21 Hb Hb NNP cord-010092-uftc8inx 5480 22 and and CC cord-010092-uftc8inx 5480 23 other other JJ cord-010092-uftc8inx 5480 24 variables variable NNS cord-010092-uftc8inx 5480 25 is be VBZ cord-010092-uftc8inx 5480 26 small small JJ cord-010092-uftc8inx 5480 27 . . . cord-010092-uftc8inx 5481 1 The the DT cord-010092-uftc8inx 5481 2 results result NNS cord-010092-uftc8inx 5481 3 cast cast VBD cord-010092-uftc8inx 5481 4 doubt doubt NN cord-010092-uftc8inx 5481 5 on on IN cord-010092-uftc8inx 5481 6 whether whether IN cord-010092-uftc8inx 5481 7 ZPP ZPP NNP cord-010092-uftc8inx 5481 8 is be VBZ cord-010092-uftc8inx 5481 9 an an DT cord-010092-uftc8inx 5481 10 effective effective JJ cord-010092-uftc8inx 5481 11 predictive predictive JJ cord-010092-uftc8inx 5481 12 marker marker NN cord-010092-uftc8inx 5481 13 for for IN cord-010092-uftc8inx 5481 14 Hb Hb NNP cord-010092-uftc8inx 5481 15 level level NN cord-010092-uftc8inx 5481 16 and and CC cord-010092-uftc8inx 5481 17 low low JJ cord-010092-uftc8inx 5481 18 Hb Hb NNP cord-010092-uftc8inx 5481 19 deferral deferral NN cord-010092-uftc8inx 5481 20 , , , cord-010092-uftc8inx 5481 21 and and CC cord-010092-uftc8inx 5481 22 suggest suggest VBP cord-010092-uftc8inx 5481 23 that that IN cord-010092-uftc8inx 5481 24 ZPP ZPP NNP cord-010092-uftc8inx 5481 25 should should MD cord-010092-uftc8inx 5481 26 not not RB cord-010092-uftc8inx 5481 27 be be VB cord-010092-uftc8inx 5481 28 included include VBN cord-010092-uftc8inx 5481 29 in in IN cord-010092-uftc8inx 5481 30 prediction prediction NN cord-010092-uftc8inx 5481 31 models model NNS cord-010092-uftc8inx 5481 32 for for IN cord-010092-uftc8inx 5481 33 Hb Hb NNP cord-010092-uftc8inx 5481 34 levels level NNS cord-010092-uftc8inx 5481 35 . . . cord-010092-uftc8inx 5482 1 By by IN cord-010092-uftc8inx 5482 2 properly properly RB cord-010092-uftc8inx 5482 3 adjusting adjust VBG cord-010092-uftc8inx 5482 4 for for IN cord-010092-uftc8inx 5482 5 associations association NNS cord-010092-uftc8inx 5482 6 between between IN cord-010092-uftc8inx 5482 7 repeated repeated JJ cord-010092-uftc8inx 5482 8 measurements measurement NNS cord-010092-uftc8inx 5482 9 and and CC cord-010092-uftc8inx 5482 10 by by IN cord-010092-uftc8inx 5482 11 using use VBG cord-010092-uftc8inx 5482 12 all all DT cord-010092-uftc8inx 5482 13 available available JJ cord-010092-uftc8inx 5482 14 data datum NNS cord-010092-uftc8inx 5482 15 , , , cord-010092-uftc8inx 5482 16 longitudinal longitudinal JJ cord-010092-uftc8inx 5482 17 models model NNS cord-010092-uftc8inx 5482 18 provide provide VBP cord-010092-uftc8inx 5482 19 less less RBR cord-010092-uftc8inx 5482 20 biased biased JJ cord-010092-uftc8inx 5482 21 and and CC cord-010092-uftc8inx 5482 22 more more RBR cord-010092-uftc8inx 5482 23 precise precise JJ cord-010092-uftc8inx 5482 24 estimates estimate NNS cord-010092-uftc8inx 5482 25 than than IN cord-010092-uftc8inx 5482 26 simpler simple JJR cord-010092-uftc8inx 5482 27 cross cross JJ cord-010092-uftc8inx 5482 28 - - JJ cord-010092-uftc8inx 5482 29 sectional sectional JJ cord-010092-uftc8inx 5482 30 analyses analysis NNS cord-010092-uftc8inx 5482 31 . . . cord-010092-uftc8inx 5483 1 Background background NN cord-010092-uftc8inx 5483 2 : : : cord-010092-uftc8inx 5484 1 Finnish Finnish NNP cord-010092-uftc8inx 5484 2 Red Red NNP cord-010092-uftc8inx 5484 3 Cross Cross NNP cord-010092-uftc8inx 5484 4 Blood Blood NNP cord-010092-uftc8inx 5484 5 Service Service NNP cord-010092-uftc8inx 5484 6 ( ( -LRB- cord-010092-uftc8inx 5484 7 FRCBS FRCBS NNP cord-010092-uftc8inx 5484 8 ) ) -RRB- cord-010092-uftc8inx 5484 9 is be VBZ cord-010092-uftc8inx 5484 10 a a DT cord-010092-uftc8inx 5484 11 national national JJ cord-010092-uftc8inx 5484 12 blood blood NN cord-010092-uftc8inx 5484 13 service service NN cord-010092-uftc8inx 5484 14 and and CC cord-010092-uftc8inx 5484 15 is be VBZ cord-010092-uftc8inx 5484 16 responsible responsible JJ cord-010092-uftc8inx 5484 17 for for IN cord-010092-uftc8inx 5484 18 all all DT cord-010092-uftc8inx 5484 19 blood blood NN cord-010092-uftc8inx 5484 20 collection collection NN cord-010092-uftc8inx 5484 21 and and CC cord-010092-uftc8inx 5484 22 component component NN cord-010092-uftc8inx 5484 23 production production NN cord-010092-uftc8inx 5484 24 in in IN cord-010092-uftc8inx 5484 25 Finland Finland NNP cord-010092-uftc8inx 5484 26 . . . cord-010092-uftc8inx 5485 1 The the DT cord-010092-uftc8inx 5485 2 highest high JJS cord-010092-uftc8inx 5485 3 age age NN cord-010092-uftc8inx 5485 4 for for IN cord-010092-uftc8inx 5485 5 blood blood NN cord-010092-uftc8inx 5485 6 donors donor NNS cord-010092-uftc8inx 5485 7 was be VBD cord-010092-uftc8inx 5485 8 66 66 CD cord-010092-uftc8inx 5485 9 years year NNS cord-010092-uftc8inx 5485 10 until until IN cord-010092-uftc8inx 5485 11 the the DT cord-010092-uftc8inx 5485 12 end end NN cord-010092-uftc8inx 5485 13 of of IN cord-010092-uftc8inx 5485 14 year year NN cord-010092-uftc8inx 5485 15 2013 2013 CD cord-010092-uftc8inx 5485 16 and and CC cord-010092-uftc8inx 5485 17 since since IN cord-010092-uftc8inx 5485 18 beginning beginning NN cord-010092-uftc8inx 5485 19 of of IN cord-010092-uftc8inx 5485 20 2014 2014 CD cord-010092-uftc8inx 5485 21 donors donor NNS cord-010092-uftc8inx 5485 22 between between IN cord-010092-uftc8inx 5485 23 66 66 CD cord-010092-uftc8inx 5485 24 and and CC cord-010092-uftc8inx 5485 25 70 70 CD cord-010092-uftc8inx 5485 26 years year NNS cord-010092-uftc8inx 5485 27 have have VBP cord-010092-uftc8inx 5485 28 been be VBN cord-010092-uftc8inx 5485 29 able able JJ cord-010092-uftc8inx 5485 30 to to TO cord-010092-uftc8inx 5485 31 donate donate VB cord-010092-uftc8inx 5485 32 blood blood NN cord-010092-uftc8inx 5485 33 . . . cord-010092-uftc8inx 5486 1 Blood blood NN cord-010092-uftc8inx 5486 2 donation donation NN cord-010092-uftc8inx 5486 3 after after IN cord-010092-uftc8inx 5486 4 the the DT cord-010092-uftc8inx 5486 5 age age NN cord-010092-uftc8inx 5486 6 66 66 CD cord-010092-uftc8inx 5486 7 is be VBZ cord-010092-uftc8inx 5486 8 possible possible JJ cord-010092-uftc8inx 5486 9 if if IN cord-010092-uftc8inx 5486 10 the the DT cord-010092-uftc8inx 5486 11 donor donor NN cord-010092-uftc8inx 5486 12 has have VBZ cord-010092-uftc8inx 5486 13 donated donate VBN cord-010092-uftc8inx 5486 14 within within IN cord-010092-uftc8inx 5486 15 the the DT cord-010092-uftc8inx 5486 16 last last JJ cord-010092-uftc8inx 5486 17 24 24 CD cord-010092-uftc8inx 5486 18 months month NNS cord-010092-uftc8inx 5486 19 . . . cord-010092-uftc8inx 5487 1 The the DT cord-010092-uftc8inx 5487 2 upper upper JJ cord-010092-uftc8inx 5487 3 age age NN cord-010092-uftc8inx 5487 4 limit limit NN cord-010092-uftc8inx 5487 5 was be VBD cord-010092-uftc8inx 5487 6 raised raise VBN cord-010092-uftc8inx 5487 7 up up RP cord-010092-uftc8inx 5487 8 based base VBN cord-010092-uftc8inx 5487 9 on on IN cord-010092-uftc8inx 5487 10 adverse adverse JJ cord-010092-uftc8inx 5487 11 event event NN cord-010092-uftc8inx 5487 12 data datum NNS cord-010092-uftc8inx 5487 13 from from IN cord-010092-uftc8inx 5487 14 FRCBS FRCBS NNP cord-010092-uftc8inx 5487 15 donors donor NNS cord-010092-uftc8inx 5487 16 up up IN cord-010092-uftc8inx 5487 17 to to IN cord-010092-uftc8inx 5487 18 66 66 CD cord-010092-uftc8inx 5487 19 years year NNS cord-010092-uftc8inx 5487 20 and and CC cord-010092-uftc8inx 5487 21 on on IN cord-010092-uftc8inx 5487 22 published publish VBN cord-010092-uftc8inx 5487 23 data datum NNS cord-010092-uftc8inx 5487 24 from from IN cord-010092-uftc8inx 5487 25 other other JJ cord-010092-uftc8inx 5487 26 Blood blood NN cord-010092-uftc8inx 5487 27 Establishments establishment NNS cord-010092-uftc8inx 5487 28 . . . cord-010092-uftc8inx 5488 1 Aims aim VBZ cord-010092-uftc8inx 5488 2 : : : cord-010092-uftc8inx 5489 1 The the DT cord-010092-uftc8inx 5489 2 aim aim NN cord-010092-uftc8inx 5489 3 of of IN cord-010092-uftc8inx 5489 4 this this DT cord-010092-uftc8inx 5489 5 study study NN cord-010092-uftc8inx 5489 6 is be VBZ cord-010092-uftc8inx 5489 7 to to TO cord-010092-uftc8inx 5489 8 find find VB cord-010092-uftc8inx 5489 9 out out RP cord-010092-uftc8inx 5489 10 if if IN cord-010092-uftc8inx 5489 11 the the DT cord-010092-uftc8inx 5489 12 new new JJ cord-010092-uftc8inx 5489 13 policy policy NN cord-010092-uftc8inx 5489 14 from from IN cord-010092-uftc8inx 5489 15 2013 2013 CD cord-010092-uftc8inx 5489 16 with with IN cord-010092-uftc8inx 5489 17 upper upper JJ cord-010092-uftc8inx 5489 18 age age NN cord-010092-uftc8inx 5489 19 limit limit NN cord-010092-uftc8inx 5489 20 of of IN cord-010092-uftc8inx 5489 21 71 71 CD cord-010092-uftc8inx 5489 22 years year NNS cord-010092-uftc8inx 5489 23 is be VBZ cord-010092-uftc8inx 5489 24 safe safe JJ cord-010092-uftc8inx 5489 25 . . . cord-010092-uftc8inx 5490 1 Therefore therefore RB cord-010092-uftc8inx 5490 2 donor donor NN cord-010092-uftc8inx 5490 3 adverse adverse JJ cord-010092-uftc8inx 5490 4 event event NN cord-010092-uftc8inx 5490 5 data datum NNS cord-010092-uftc8inx 5490 6 was be VBD cord-010092-uftc8inx 5490 7 analyzed analyze VBN cord-010092-uftc8inx 5490 8 in in IN cord-010092-uftc8inx 5490 9 order order NN cord-010092-uftc8inx 5490 10 to to TO cord-010092-uftc8inx 5490 11 evaluate evaluate VB cord-010092-uftc8inx 5490 12 if if IN cord-010092-uftc8inx 5490 13 the the DT cord-010092-uftc8inx 5490 14 blood blood NN cord-010092-uftc8inx 5490 15 donors donor NNS cord-010092-uftc8inx 5490 16 older old JJR cord-010092-uftc8inx 5490 17 than than IN cord-010092-uftc8inx 5490 18 66 66 CD cord-010092-uftc8inx 5490 19 years year NNS cord-010092-uftc8inx 5490 20 have have VBP cord-010092-uftc8inx 5490 21 more more RBR cord-010092-uftc8inx 5490 22 adverse adverse JJ cord-010092-uftc8inx 5490 23 events event NNS cord-010092-uftc8inx 5490 24 compared compare VBN cord-010092-uftc8inx 5490 25 to to IN cord-010092-uftc8inx 5490 26 other other JJ cord-010092-uftc8inx 5490 27 donors donor NNS cord-010092-uftc8inx 5490 28 . . . cord-010092-uftc8inx 5491 1 The the DT cord-010092-uftc8inx 5491 2 most most RBS cord-010092-uftc8inx 5491 3 common common JJ cord-010092-uftc8inx 5491 4 donor donor NN cord-010092-uftc8inx 5491 5 adverse adverse JJ cord-010092-uftc8inx 5491 6 event event NN cord-010092-uftc8inx 5491 7 for for IN cord-010092-uftc8inx 5491 8 donors donor NNS cord-010092-uftc8inx 5491 9 over over IN cord-010092-uftc8inx 5491 10 66 66 CD cord-010092-uftc8inx 5491 11 years year NNS cord-010092-uftc8inx 5491 12 , , , cord-010092-uftc8inx 5491 13 haematoma haematoma NN cord-010092-uftc8inx 5491 14 , , , cord-010092-uftc8inx 5491 15 was be VBD cord-010092-uftc8inx 5491 16 registered register VBN cord-010092-uftc8inx 5491 17 211 211 CD cord-010092-uftc8inx 5491 18 times time NNS cord-010092-uftc8inx 5491 19 ( ( -LRB- cord-010092-uftc8inx 5491 20 0.05 0.05 CD cord-010092-uftc8inx 5491 21 % % NN cord-010092-uftc8inx 5491 22 ) ) -RRB- cord-010092-uftc8inx 5491 23 . . . cord-010092-uftc8inx 5492 1 In in IN cord-010092-uftc8inx 5492 2 the the DT cord-010092-uftc8inx 5492 3 other other JJ cord-010092-uftc8inx 5492 4 age age NN cord-010092-uftc8inx 5492 5 groups group NNS cord-010092-uftc8inx 5492 6 haematoma haematoma NN cord-010092-uftc8inx 5492 7 was be VBD cord-010092-uftc8inx 5492 8 registered register VBN cord-010092-uftc8inx 5492 9 4408 4408 CD cord-010092-uftc8inx 5492 10 times time NNS cord-010092-uftc8inx 5492 11 ( ( -LRB- cord-010092-uftc8inx 5492 12 0.56 0.56 CD cord-010092-uftc8inx 5492 13 % % NN cord-010092-uftc8inx 5492 14 ) ) -RRB- cord-010092-uftc8inx 5492 15 and and CC cord-010092-uftc8inx 5492 16 the the DT cord-010092-uftc8inx 5492 17 difference difference NN cord-010092-uftc8inx 5492 18 between between IN cord-010092-uftc8inx 5492 19 the the DT cord-010092-uftc8inx 5492 20 oldest old JJS cord-010092-uftc8inx 5492 21 age age NN cord-010092-uftc8inx 5492 22 group group NN cord-010092-uftc8inx 5492 23 compared compare VBN cord-010092-uftc8inx 5492 24 to to IN cord-010092-uftc8inx 5492 25 all all DT cord-010092-uftc8inx 5492 26 other other JJ cord-010092-uftc8inx 5492 27 donors donor NNS cord-010092-uftc8inx 5492 28 was be VBD cord-010092-uftc8inx 5492 29 statistically statistically RB cord-010092-uftc8inx 5492 30 not not RB cord-010092-uftc8inx 5492 31 significant significant JJ cord-010092-uftc8inx 5492 32 ( ( -LRB- cord-010092-uftc8inx 5492 33 Chi2 Chi2 NNP cord-010092-uftc8inx 5492 34 , , , cord-010092-uftc8inx 5492 35 P p NN cord-010092-uftc8inx 5492 36 = = SYM cord-010092-uftc8inx 5492 37 0.012 0.012 CD cord-010092-uftc8inx 5492 38 ) ) -RRB- cord-010092-uftc8inx 5492 39 . . . cord-010092-uftc8inx 5493 1 VVRs VVRs NNP cord-010092-uftc8inx 5493 2 with with IN cord-010092-uftc8inx 5493 3 LOC LOC NNP cord-010092-uftc8inx 5493 4 were be VBD cord-010092-uftc8inx 5493 5 registered register VBN cord-010092-uftc8inx 5493 6 21 21 CD cord-010092-uftc8inx 5493 7 times time NNS cord-010092-uftc8inx 5493 8 ( ( -LRB- cord-010092-uftc8inx 5493 9 0.05 0.05 CD cord-010092-uftc8inx 5493 10 % % NN cord-010092-uftc8inx 5493 11 ) ) -RRB- cord-010092-uftc8inx 5493 12 , , , cord-010092-uftc8inx 5493 13 VVRs vvrs NN cord-010092-uftc8inx 5493 14 without without IN cord-010092-uftc8inx 5493 15 LOC LOC NNP cord-010092-uftc8inx 5493 16 25 25 CD cord-010092-uftc8inx 5493 17 times time NNS cord-010092-uftc8inx 5493 18 ( ( -LRB- cord-010092-uftc8inx 5493 19 0.06 0.06 CD cord-010092-uftc8inx 5493 20 ) ) -RRB- cord-010092-uftc8inx 5493 21 , , , cord-010092-uftc8inx 5493 22 and and CC cord-010092-uftc8inx 5493 23 the the DT cord-010092-uftc8inx 5493 24 total total JJ cord-010092-uftc8inx 5493 25 number number NN cord-010092-uftc8inx 5493 26 of of IN cord-010092-uftc8inx 5493 27 all all DT cord-010092-uftc8inx 5493 28 DAEs dae NNS cord-010092-uftc8inx 5493 29 was be VBD cord-010092-uftc8inx 5493 30 293 293 CD cord-010092-uftc8inx 5493 31 ( ( -LRB- cord-010092-uftc8inx 5493 32 0.65 0.65 CD cord-010092-uftc8inx 5493 33 % % NN cord-010092-uftc8inx 5493 34 ) ) -RRB- cord-010092-uftc8inx 5493 35 in in IN cord-010092-uftc8inx 5493 36 the the DT cord-010092-uftc8inx 5493 37 age age NN cord-010092-uftc8inx 5493 38 group group NN cord-010092-uftc8inx 5493 39 66 66 CD cord-010092-uftc8inx 5493 40 years year NNS cord-010092-uftc8inx 5493 41 or or CC cord-010092-uftc8inx 5493 42 older old JJR cord-010092-uftc8inx 5493 43 . . . cord-010092-uftc8inx 5494 1 The the DT cord-010092-uftc8inx 5494 2 respective respective JJ cord-010092-uftc8inx 5494 3 numbers number NNS cord-010092-uftc8inx 5494 4 in in IN cord-010092-uftc8inx 5494 5 the the DT cord-010092-uftc8inx 5494 6 other other JJ cord-010092-uftc8inx 5494 7 age age NN cord-010092-uftc8inx 5494 8 group group NN cord-010092-uftc8inx 5494 9 were be VBD cord-010092-uftc8inx 5494 10 : : : cord-010092-uftc8inx 5494 11 1152 1152 CD cord-010092-uftc8inx 5494 12 , , , cord-010092-uftc8inx 5494 13 0.15 0.15 CD cord-010092-uftc8inx 5494 14 % % NN cord-010092-uftc8inx 5494 15 ; ; : cord-010092-uftc8inx 5494 16 11055 11055 CD cord-010092-uftc8inx 5494 17 , , , cord-010092-uftc8inx 5494 18 1.41 1.41 CD cord-010092-uftc8inx 5494 19 % % NN cord-010092-uftc8inx 5494 20 ; ; : cord-010092-uftc8inx 5494 21 17550 17550 CD cord-010092-uftc8inx 5494 22 ( ( -LRB- cord-010092-uftc8inx 5494 23 2.23 2.23 CD cord-010092-uftc8inx 5494 24 % % NN cord-010092-uftc8inx 5494 25 ) ) -RRB- cord-010092-uftc8inx 5494 26 . . . cord-010092-uftc8inx 5495 1 The the DT cord-010092-uftc8inx 5495 2 number number NN cord-010092-uftc8inx 5495 3 of of IN cord-010092-uftc8inx 5495 4 VVRs vvrs NN cord-010092-uftc8inx 5495 5 with with IN cord-010092-uftc8inx 5495 6 and and CC cord-010092-uftc8inx 5495 7 without without IN cord-010092-uftc8inx 5495 8 LOC LOC NNP cord-010092-uftc8inx 5495 9 , , , cord-010092-uftc8inx 5495 10 and and CC cord-010092-uftc8inx 5495 11 total total JJ cord-010092-uftc8inx 5495 12 number number NN cord-010092-uftc8inx 5495 13 of of IN cord-010092-uftc8inx 5495 14 all all DT cord-010092-uftc8inx 5495 15 DAEs dae NNS cord-010092-uftc8inx 5495 16 in in IN cord-010092-uftc8inx 5495 17 the the DT cord-010092-uftc8inx 5495 18 age age NN cord-010092-uftc8inx 5495 19 group group NN cord-010092-uftc8inx 5495 20 66 66 CD cord-010092-uftc8inx 5495 21 years year NNS cord-010092-uftc8inx 5495 22 and and CC cord-010092-uftc8inx 5495 23 older old JJR cord-010092-uftc8inx 5495 24 was be VBD cord-010092-uftc8inx 5495 25 smaller small JJR cord-010092-uftc8inx 5495 26 than than IN cord-010092-uftc8inx 5495 27 in in IN cord-010092-uftc8inx 5495 28 the the DT cord-010092-uftc8inx 5495 29 other other JJ cord-010092-uftc8inx 5495 30 groups group NNS cord-010092-uftc8inx 5495 31 and and CC cord-010092-uftc8inx 5495 32 the the DT cord-010092-uftc8inx 5495 33 difference difference NN cord-010092-uftc8inx 5495 34 between between IN cord-010092-uftc8inx 5495 35 these these DT cord-010092-uftc8inx 5495 36 groups group NNS cord-010092-uftc8inx 5495 37 was be VBD cord-010092-uftc8inx 5495 38 statistical statistical JJ cord-010092-uftc8inx 5495 39 significant significant JJ cord-010092-uftc8inx 5495 40 ( ( -LRB- cord-010092-uftc8inx 5495 41 Chi2 Chi2 NNP cord-010092-uftc8inx 5495 42 , , , cord-010092-uftc8inx 5495 43 P p NN cord-010092-uftc8inx 5495 44 < < XX cord-010092-uftc8inx 5495 45 0.0001 0.0001 CD cord-010092-uftc8inx 5495 46 ) ) -RRB- cord-010092-uftc8inx 5495 47 . . . cord-010092-uftc8inx 5496 1 Summary Summary NNP cord-010092-uftc8inx 5496 2 / / SYM cord-010092-uftc8inx 5496 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 5496 4 : : : cord-010092-uftc8inx 5497 1 Donors donor NNS cord-010092-uftc8inx 5497 2 over over IN cord-010092-uftc8inx 5497 3 the the DT cord-010092-uftc8inx 5497 4 age age NN cord-010092-uftc8inx 5497 5 of of IN cord-010092-uftc8inx 5497 6 66 66 CD cord-010092-uftc8inx 5497 7 years year NNS cord-010092-uftc8inx 5497 8 have have VBP cord-010092-uftc8inx 5497 9 less less JJR cord-010092-uftc8inx 5497 10 donor donor NN cord-010092-uftc8inx 5497 11 adverse adverse JJ cord-010092-uftc8inx 5497 12 events event NNS cord-010092-uftc8inx 5497 13 than than IN cord-010092-uftc8inx 5497 14 other other JJ cord-010092-uftc8inx 5497 15 age age NN cord-010092-uftc8inx 5497 16 groups group NNS cord-010092-uftc8inx 5497 17 . . . cord-010092-uftc8inx 5498 1 Decision decision NN cord-010092-uftc8inx 5498 2 to to TO cord-010092-uftc8inx 5498 3 raise raise VB cord-010092-uftc8inx 5498 4 the the DT cord-010092-uftc8inx 5498 5 age age NN cord-010092-uftc8inx 5498 6 limit limit NN cord-010092-uftc8inx 5498 7 from from IN cord-010092-uftc8inx 5498 8 66 66 CD cord-010092-uftc8inx 5498 9 to to IN cord-010092-uftc8inx 5498 10 71 71 CD cord-010092-uftc8inx 5498 11 seems seem VBZ cord-010092-uftc8inx 5498 12 proven prove VBN cord-010092-uftc8inx 5498 13 to to TO cord-010092-uftc8inx 5498 14 be be VB cord-010092-uftc8inx 5498 15 right right JJ cord-010092-uftc8inx 5498 16 as as IN cord-010092-uftc8inx 5498 17 the the DT cord-010092-uftc8inx 5498 18 older old JJR cord-010092-uftc8inx 5498 19 age age NN cord-010092-uftc8inx 5498 20 group group NN cord-010092-uftc8inx 5498 21 has have VBZ cord-010092-uftc8inx 5498 22 even even RB cord-010092-uftc8inx 5498 23 less less JJR cord-010092-uftc8inx 5498 24 donor donor NN cord-010092-uftc8inx 5498 25 adverse adverse JJ cord-010092-uftc8inx 5498 26 events event NNS cord-010092-uftc8inx 5498 27 than than IN cord-010092-uftc8inx 5498 28 other other JJ cord-010092-uftc8inx 5498 29 donors donor NNS cord-010092-uftc8inx 5498 30 . . . cord-010092-uftc8inx 5499 1 Background background NN cord-010092-uftc8inx 5499 2 : : : cord-010092-uftc8inx 5500 1 Deep Deep NNP cord-010092-uftc8inx 5500 2 Vein Vein NNP cord-010092-uftc8inx 5500 3 Thrombosis Thrombosis NNP cord-010092-uftc8inx 5500 4 ( ( -LRB- cord-010092-uftc8inx 5500 5 DVT DVT NNP cord-010092-uftc8inx 5500 6 ) ) -RRB- cord-010092-uftc8inx 5500 7 of of IN cord-010092-uftc8inx 5500 8 the the DT cord-010092-uftc8inx 5500 9 donor donor NN cord-010092-uftc8inx 5500 10 's 's POS cord-010092-uftc8inx 5500 11 phlebotomy phlebotomy NN cord-010092-uftc8inx 5500 12 arm arm NN cord-010092-uftc8inx 5500 13 is be VBZ cord-010092-uftc8inx 5500 14 a a DT cord-010092-uftc8inx 5500 15 rare rare JJ cord-010092-uftc8inx 5500 16 , , , cord-010092-uftc8inx 5500 17 but but CC cord-010092-uftc8inx 5500 18 serious serious JJ cord-010092-uftc8inx 5500 19 complication complication NN cord-010092-uftc8inx 5500 20 of of IN cord-010092-uftc8inx 5500 21 blood blood NN cord-010092-uftc8inx 5500 22 donation donation NN cord-010092-uftc8inx 5500 23 that that WDT cord-010092-uftc8inx 5500 24 needs need VBZ cord-010092-uftc8inx 5500 25 to to TO cord-010092-uftc8inx 5500 26 be be VB cord-010092-uftc8inx 5500 27 recognised recognise VBN cord-010092-uftc8inx 5500 28 and and CC cord-010092-uftc8inx 5500 29 managed manage VBN cord-010092-uftc8inx 5500 30 appropriately appropriately RB cord-010092-uftc8inx 5500 31 in in IN cord-010092-uftc8inx 5500 32 a a DT cord-010092-uftc8inx 5500 33 timely timely JJ cord-010092-uftc8inx 5500 34 manner manner NN cord-010092-uftc8inx 5500 35 . . . cord-010092-uftc8inx 5501 1 Post post JJ cord-010092-uftc8inx 5501 2 donation donation NN cord-010092-uftc8inx 5501 3 DVT DVT NNP cord-010092-uftc8inx 5501 4 will will MD cord-010092-uftc8inx 5501 5 be be VB cord-010092-uftc8inx 5501 6 classed class VBN cord-010092-uftc8inx 5501 7 as as IN cord-010092-uftc8inx 5501 8 a a DT cord-010092-uftc8inx 5501 9 ' ' `` cord-010092-uftc8inx 5501 10 Serious serious JJ cord-010092-uftc8inx 5501 11 adverse adverse JJ cord-010092-uftc8inx 5501 12 events event NNS cord-010092-uftc8inx 5501 13 of of IN cord-010092-uftc8inx 5501 14 donation donation NN cord-010092-uftc8inx 5501 15 ' ' '' cord-010092-uftc8inx 5501 16 ( ( -LRB- cord-010092-uftc8inx 5501 17 SAEDs)these SAEDs)these NNP cord-010092-uftc8inx 5501 18 are be VBP cord-010092-uftc8inx 5501 19 events event NNS cord-010092-uftc8inx 5501 20 that that WDT cord-010092-uftc8inx 5501 21 either either DT cord-010092-uftc8inx 5501 22 result result VBP cord-010092-uftc8inx 5501 23 in in IN cord-010092-uftc8inx 5501 24 donor donor NN cord-010092-uftc8inx 5501 25 death death NN cord-010092-uftc8inx 5501 26 , , , cord-010092-uftc8inx 5501 27 hospitalisation hospitalisation NN cord-010092-uftc8inx 5501 28 , , , cord-010092-uftc8inx 5501 29 intervention intervention NN cord-010092-uftc8inx 5501 30 or or CC cord-010092-uftc8inx 5501 31 significant significant JJ cord-010092-uftc8inx 5501 32 symptoms symptom NNS cord-010092-uftc8inx 5501 33 persisting persist VBG cord-010092-uftc8inx 5501 34 for for IN cord-010092-uftc8inx 5501 35 more more JJR cord-010092-uftc8inx 5501 36 than than IN cord-010092-uftc8inx 5501 37 one one CD cord-010092-uftc8inx 5501 38 - - HYPH cord-010092-uftc8inx 5501 39 year year NN cord-010092-uftc8inx 5501 40 post post NN cord-010092-uftc8inx 5501 41 donation donation NN cord-010092-uftc8inx 5501 42 . . . cord-010092-uftc8inx 5502 1 Aims aim VBZ cord-010092-uftc8inx 5502 2 : : : cord-010092-uftc8inx 5503 1 To to TO cord-010092-uftc8inx 5503 2 review review VB cord-010092-uftc8inx 5503 3 cases case NNS cord-010092-uftc8inx 5503 4 of of IN cord-010092-uftc8inx 5503 5 DVT DVT NNP cord-010092-uftc8inx 5503 6 post post NN cord-010092-uftc8inx 5503 7 donation donation NN cord-010092-uftc8inx 5503 8 reported report VBN cord-010092-uftc8inx 5503 9 in in IN cord-010092-uftc8inx 5503 10 UK UK NNP cord-010092-uftc8inx 5503 11 in in IN cord-010092-uftc8inx 5503 12 2016 2016 CD cord-010092-uftc8inx 5503 13 - - SYM cord-010092-uftc8inx 5503 14 2018 2018 CD cord-010092-uftc8inx 5503 15 years year NNS cord-010092-uftc8inx 5503 16 and and CC cord-010092-uftc8inx 5503 17 identify identify VB cord-010092-uftc8inx 5503 18 any any DT cord-010092-uftc8inx 5503 19 common common JJ cord-010092-uftc8inx 5503 20 themes theme NNS cord-010092-uftc8inx 5503 21 for for IN cord-010092-uftc8inx 5503 22 improving improve VBG cord-010092-uftc8inx 5503 23 practice practice NN cord-010092-uftc8inx 5503 24 Methods method NNS cord-010092-uftc8inx 5503 25 : : : cord-010092-uftc8inx 5503 26 All all DT cord-010092-uftc8inx 5503 27 data datum NNS cord-010092-uftc8inx 5503 28 relating relate VBG cord-010092-uftc8inx 5503 29 to to IN cord-010092-uftc8inx 5503 30 SAEDs saed NNS cord-010092-uftc8inx 5503 31 from from IN cord-010092-uftc8inx 5503 32 the the DT cord-010092-uftc8inx 5503 33 four four CD cord-010092-uftc8inx 5503 34 UK UK NNP cord-010092-uftc8inx 5503 35 Blood Blood NNP cord-010092-uftc8inx 5503 36 Services Services NNPS cord-010092-uftc8inx 5503 37 reported report VBD cord-010092-uftc8inx 5503 38 to to IN cord-010092-uftc8inx 5503 39 SHOT shot NN cord-010092-uftc8inx 5503 40 in in IN cord-010092-uftc8inx 5503 41 the the DT cord-010092-uftc8inx 5503 42 last last JJ cord-010092-uftc8inx 5503 43 3 3 CD cord-010092-uftc8inx 5503 44 years year NNS cord-010092-uftc8inx 5503 45 ( ( -LRB- cord-010092-uftc8inx 5503 46 2016 2016 CD cord-010092-uftc8inx 5503 47 - - SYM cord-010092-uftc8inx 5503 48 2018 2018 CD cord-010092-uftc8inx 5503 49 inclusive inclusive JJ cord-010092-uftc8inx 5503 50 ) ) -RRB- cord-010092-uftc8inx 5503 51 were be VBD cord-010092-uftc8inx 5503 52 reviewed review VBN cord-010092-uftc8inx 5503 53 to to TO cord-010092-uftc8inx 5503 54 look look VB cord-010092-uftc8inx 5503 55 for for IN cord-010092-uftc8inx 5503 56 reports report NNS cord-010092-uftc8inx 5503 57 of of IN cord-010092-uftc8inx 5503 58 DVT DVT NNP cord-010092-uftc8inx 5503 59 post post NN cord-010092-uftc8inx 5503 60 donation donation NN cord-010092-uftc8inx 5503 61 Results result NNS cord-010092-uftc8inx 5503 62 : : : cord-010092-uftc8inx 5503 63 A a DT cord-010092-uftc8inx 5503 64 total total NN cord-010092-uftc8inx 5503 65 of of IN cord-010092-uftc8inx 5503 66 135 135 CD cord-010092-uftc8inx 5503 67 SAEDs saed NNS cord-010092-uftc8inx 5503 68 were be VBD cord-010092-uftc8inx 5503 69 reported report VBN cord-010092-uftc8inx 5503 70 in in IN cord-010092-uftc8inx 5503 71 UK UK NNP cord-010092-uftc8inx 5503 72 from from IN cord-010092-uftc8inx 5503 73 approximately approximately RB cord-010092-uftc8inx 5503 74 5.8 5.8 CD cord-010092-uftc8inx 5503 75 million million CD cord-010092-uftc8inx 5503 76 donations donation NNS cord-010092-uftc8inx 5503 77 ( ( -LRB- cord-010092-uftc8inx 5503 78 whole whole JJ cord-010092-uftc8inx 5503 79 blood blood NN cord-010092-uftc8inx 5503 80 and and CC cord-010092-uftc8inx 5503 81 apheresis apheresis NN cord-010092-uftc8inx 5503 82 ) ) -RRB- cord-010092-uftc8inx 5503 83 collected collect VBN cord-010092-uftc8inx 5503 84 during during IN cord-010092-uftc8inx 5503 85 this this DT cord-010092-uftc8inx 5503 86 period period NN cord-010092-uftc8inx 5503 87 . . . cord-010092-uftc8inx 5504 1 Three three CD cord-010092-uftc8inx 5504 2 cases case NNS cord-010092-uftc8inx 5504 3 of of IN cord-010092-uftc8inx 5504 4 upper upper JJ cord-010092-uftc8inx 5504 5 limb limb NN cord-010092-uftc8inx 5504 6 DVT DVT NNP cord-010092-uftc8inx 5504 7 were be VBD cord-010092-uftc8inx 5504 8 reported report VBN cord-010092-uftc8inx 5504 9 during during IN cord-010092-uftc8inx 5504 10 this this DT cord-010092-uftc8inx 5504 11 time time NN cord-010092-uftc8inx 5504 12 accounting account VBG cord-010092-uftc8inx 5504 13 for for IN cord-010092-uftc8inx 5504 14 2 2 CD cord-010092-uftc8inx 5504 15 % % NN cord-010092-uftc8inx 5504 16 of of IN cord-010092-uftc8inx 5504 17 the the DT cord-010092-uftc8inx 5504 18 SAEDs SAEDs NNPS cord-010092-uftc8inx 5504 19 reported report VBN cord-010092-uftc8inx 5504 20 and and CC cord-010092-uftc8inx 5504 21 rate rate NN cord-010092-uftc8inx 5504 22 of of IN cord-010092-uftc8inx 5504 23 DVT DVT NNP cord-010092-uftc8inx 5504 24 of of IN cord-010092-uftc8inx 5504 25 1 1 CD cord-010092-uftc8inx 5504 26 in in IN cord-010092-uftc8inx 5504 27 1.9 1.9 CD cord-010092-uftc8inx 5504 28 million million CD cord-010092-uftc8inx 5504 29 donations donation NNS cord-010092-uftc8inx 5504 30 collected collect VBN cord-010092-uftc8inx 5504 31 . . . cord-010092-uftc8inx 5505 1 -Case -case NN cord-010092-uftc8inx 5505 2 1 1 CD cord-010092-uftc8inx 5505 3 : : : cord-010092-uftc8inx 5505 4 A a DT cord-010092-uftc8inx 5505 5 regular regular JJ cord-010092-uftc8inx 5505 6 male male JJ cord-010092-uftc8inx 5505 7 whole whole JJ cord-010092-uftc8inx 5505 8 blood blood NN cord-010092-uftc8inx 5505 9 donor donor NN cord-010092-uftc8inx 5505 10 in in IN cord-010092-uftc8inx 5505 11 his -PRON- PRP$ cord-010092-uftc8inx 5505 12 early early JJ cord-010092-uftc8inx 5505 13 30s 30 NNS cord-010092-uftc8inx 5505 14 reported report VBD cord-010092-uftc8inx 5505 15 worsening worsen VBG cord-010092-uftc8inx 5505 16 arm arm NN cord-010092-uftc8inx 5505 17 pain pain NN cord-010092-uftc8inx 5505 18 12 12 CD cord-010092-uftc8inx 5505 19 days day NNS cord-010092-uftc8inx 5505 20 following follow VBG cord-010092-uftc8inx 5505 21 blood blood NN cord-010092-uftc8inx 5505 22 donation donation NN cord-010092-uftc8inx 5505 23 , , , cord-010092-uftc8inx 5505 24 had have VBD cord-010092-uftc8inx 5505 25 a a DT cord-010092-uftc8inx 5505 26 painful painful JJ cord-010092-uftc8inx 5505 27 venepuncture venepuncture NN cord-010092-uftc8inx 5505 28 and and CC cord-010092-uftc8inx 5505 29 a a DT cord-010092-uftc8inx 5505 30 small small JJ cord-010092-uftc8inx 5505 31 bruise bruise NN cord-010092-uftc8inx 5505 32 at at IN cord-010092-uftc8inx 5505 33 site site NN cord-010092-uftc8inx 5505 34 of of IN cord-010092-uftc8inx 5505 35 donation donation NN cord-010092-uftc8inx 5505 36 . . . cord-010092-uftc8inx 5506 1 He -PRON- PRP cord-010092-uftc8inx 5506 2 was be VBD cord-010092-uftc8inx 5506 3 diagnosed diagnose VBN cord-010092-uftc8inx 5506 4 to to TO cord-010092-uftc8inx 5506 5 have have VB cord-010092-uftc8inx 5506 6 an an DT cord-010092-uftc8inx 5506 7 upper upper JJ cord-010092-uftc8inx 5506 8 limb limb NN cord-010092-uftc8inx 5506 9 DVT DVT NNP cord-010092-uftc8inx 5506 10 extending extend VBG cord-010092-uftc8inx 5506 11 to to IN cord-010092-uftc8inx 5506 12 the the DT cord-010092-uftc8inx 5506 13 subclavian subclavian JJ cord-010092-uftc8inx 5506 14 and and CC cord-010092-uftc8inx 5506 15 brachiocephalic brachiocephalic NNP cord-010092-uftc8inx 5506 16 vein vein NN cord-010092-uftc8inx 5506 17 and and CC cord-010092-uftc8inx 5506 18 started start VBD cord-010092-uftc8inx 5506 19 on on IN cord-010092-uftc8inx 5506 20 oral oral JJ cord-010092-uftc8inx 5506 21 anticoagulants anticoagulant NNS cord-010092-uftc8inx 5506 22 . . . cord-010092-uftc8inx 5507 1 No no DT cord-010092-uftc8inx 5507 2 other other JJ cord-010092-uftc8inx 5507 3 contributory contributory JJ cord-010092-uftc8inx 5507 4 factor factor NN cord-010092-uftc8inx 5507 5 was be VBD cord-010092-uftc8inx 5507 6 obvious obvious JJ cord-010092-uftc8inx 5507 7 -Case -Case NNP cord-010092-uftc8inx 5507 8 2 2 CD cord-010092-uftc8inx 5507 9 : : : cord-010092-uftc8inx 5508 1 A a DT cord-010092-uftc8inx 5508 2 female female JJ cord-010092-uftc8inx 5508 3 donor donor NN cord-010092-uftc8inx 5508 4 in in IN cord-010092-uftc8inx 5508 5 her -PRON- PRP$ cord-010092-uftc8inx 5508 6 mid-40s mid-40 NNS cord-010092-uftc8inx 5508 7 gave give VBD cord-010092-uftc8inx 5508 8 her -PRON- PRP$ cord-010092-uftc8inx 5508 9 sixth sixth JJ cord-010092-uftc8inx 5508 10 whole whole JJ cord-010092-uftc8inx 5508 11 blood blood NN cord-010092-uftc8inx 5508 12 donation donation NN cord-010092-uftc8inx 5508 13 without without IN cord-010092-uftc8inx 5508 14 event event NN cord-010092-uftc8inx 5508 15 . . . cord-010092-uftc8inx 5509 1 11 11 CD cord-010092-uftc8inx 5509 2 days day NNS cord-010092-uftc8inx 5509 3 after after IN cord-010092-uftc8inx 5509 4 donation donation NN cord-010092-uftc8inx 5509 5 , , , cord-010092-uftc8inx 5509 6 she -PRON- PRP cord-010092-uftc8inx 5509 7 developed develop VBD cord-010092-uftc8inx 5509 8 worsening worsen VBG cord-010092-uftc8inx 5509 9 arm arm NN cord-010092-uftc8inx 5509 10 pain pain NN cord-010092-uftc8inx 5509 11 in in IN cord-010092-uftc8inx 5509 12 the the DT cord-010092-uftc8inx 5509 13 donation donation NN cord-010092-uftc8inx 5509 14 arm arm NN cord-010092-uftc8inx 5509 15 and and CC cord-010092-uftc8inx 5509 16 was be VBD cord-010092-uftc8inx 5509 17 diagnosed diagnose VBN cord-010092-uftc8inx 5509 18 with with IN cord-010092-uftc8inx 5509 19 an an DT cord-010092-uftc8inx 5509 20 upper upper JJ cord-010092-uftc8inx 5509 21 limb limb NN cord-010092-uftc8inx 5509 22 DVT DVT NNP cord-010092-uftc8inx 5509 23 and and CC cord-010092-uftc8inx 5509 24 commenced commence VBD cord-010092-uftc8inx 5509 25 oral oral JJ cord-010092-uftc8inx 5509 26 anticoagulation anticoagulation NN cord-010092-uftc8inx 5509 27 . . . cord-010092-uftc8inx 5510 1 There there EX cord-010092-uftc8inx 5510 2 was be VBD cord-010092-uftc8inx 5510 3 no no DT cord-010092-uftc8inx 5510 4 other other JJ cord-010092-uftc8inx 5510 5 identifiable identifiable JJ cord-010092-uftc8inx 5510 6 risk risk NN cord-010092-uftc8inx 5510 7 factor factor NN cord-010092-uftc8inx 5510 8 for for IN cord-010092-uftc8inx 5510 9 the the DT cord-010092-uftc8inx 5510 10 thrombosis thrombosis NN cord-010092-uftc8inx 5510 11 -Case -Case NNP cord-010092-uftc8inx 5510 12 3 3 CD cord-010092-uftc8inx 5510 13 : : : cord-010092-uftc8inx 5510 14 A a DT cord-010092-uftc8inx 5510 15 female female JJ cord-010092-uftc8inx 5510 16 donor donor NN cord-010092-uftc8inx 5510 17 in in IN cord-010092-uftc8inx 5510 18 her -PRON- PRP$ cord-010092-uftc8inx 5510 19 20s 20 NNS cord-010092-uftc8inx 5510 20 developed develop VBD cord-010092-uftc8inx 5510 21 pain pain NN cord-010092-uftc8inx 5510 22 , , , cord-010092-uftc8inx 5510 23 swelling swelling NN cord-010092-uftc8inx 5510 24 , , , cord-010092-uftc8inx 5510 25 redness redness NN cord-010092-uftc8inx 5510 26 and and CC cord-010092-uftc8inx 5510 27 itchiness itchiness NN cord-010092-uftc8inx 5510 28 in in IN cord-010092-uftc8inx 5510 29 her -PRON- PRP$ cord-010092-uftc8inx 5510 30 donation donation NN cord-010092-uftc8inx 5510 31 arm arm NN cord-010092-uftc8inx 5510 32 and and CC cord-010092-uftc8inx 5510 33 chest chest NN cord-010092-uftc8inx 5510 34 wall wall NN cord-010092-uftc8inx 5510 35 two two CD cord-010092-uftc8inx 5510 36 days day NNS cord-010092-uftc8inx 5510 37 after after IN cord-010092-uftc8inx 5510 38 donation donation NN cord-010092-uftc8inx 5510 39 . . . cord-010092-uftc8inx 5511 1 She -PRON- PRP cord-010092-uftc8inx 5511 2 also also RB cord-010092-uftc8inx 5511 3 described describe VBD cord-010092-uftc8inx 5511 4 prominent prominent JJ cord-010092-uftc8inx 5511 5 veins vein NNS cord-010092-uftc8inx 5511 6 on on IN cord-010092-uftc8inx 5511 7 the the DT cord-010092-uftc8inx 5511 8 affected affected JJ cord-010092-uftc8inx 5511 9 side side NN cord-010092-uftc8inx 5511 10 compared compare VBN cord-010092-uftc8inx 5511 11 to to IN cord-010092-uftc8inx 5511 12 her -PRON- PRP$ cord-010092-uftc8inx 5511 13 other other JJ cord-010092-uftc8inx 5511 14 arm arm NN cord-010092-uftc8inx 5511 15 . . . cord-010092-uftc8inx 5512 1 She -PRON- PRP cord-010092-uftc8inx 5512 2 contacted contact VBD cord-010092-uftc8inx 5512 3 the the DT cord-010092-uftc8inx 5512 4 transfusion transfusion NN cord-010092-uftc8inx 5512 5 service service NN cord-010092-uftc8inx 5512 6 one one CD cord-010092-uftc8inx 5512 7 week week NN cord-010092-uftc8inx 5512 8 after after IN cord-010092-uftc8inx 5512 9 donation donation NN cord-010092-uftc8inx 5512 10 ; ; : cord-010092-uftc8inx 5512 11 by by IN cord-010092-uftc8inx 5512 12 this this DT cord-010092-uftc8inx 5512 13 time time NN cord-010092-uftc8inx 5512 14 she -PRON- PRP cord-010092-uftc8inx 5512 15 was be VBD cord-010092-uftc8inx 5512 16 also also RB cord-010092-uftc8inx 5512 17 breathless breathless JJ cord-010092-uftc8inx 5512 18 on on IN cord-010092-uftc8inx 5512 19 minimal minimal JJ cord-010092-uftc8inx 5512 20 exertion exertion NN cord-010092-uftc8inx 5512 21 . . . cord-010092-uftc8inx 5513 1 She -PRON- PRP cord-010092-uftc8inx 5513 2 was be VBD cord-010092-uftc8inx 5513 3 admitted admit VBN cord-010092-uftc8inx 5513 4 to to IN cord-010092-uftc8inx 5513 5 hospital hospital NN cord-010092-uftc8inx 5513 6 and and CC cord-010092-uftc8inx 5513 7 commenced commence VBD cord-010092-uftc8inx 5513 8 on on IN cord-010092-uftc8inx 5513 9 anticoagulant anticoagulant JJ cord-010092-uftc8inx 5513 10 therapy therapy NN cord-010092-uftc8inx 5513 11 . . . cord-010092-uftc8inx 5514 1 A a DT cord-010092-uftc8inx 5514 2 diagnosis diagnosis NN cord-010092-uftc8inx 5514 3 of of IN cord-010092-uftc8inx 5514 4 DVT DVT NNP cord-010092-uftc8inx 5514 5 and and CC cord-010092-uftc8inx 5514 6 associated associated JJ cord-010092-uftc8inx 5514 7 pulmonary pulmonary JJ cord-010092-uftc8inx 5514 8 embolus embolus NN cord-010092-uftc8inx 5514 9 was be VBD cord-010092-uftc8inx 5514 10 confirmed confirm VBN cord-010092-uftc8inx 5514 11 . . . cord-010092-uftc8inx 5515 1 The the DT cord-010092-uftc8inx 5515 2 donor donor NN cord-010092-uftc8inx 5515 3 's 's POS cord-010092-uftc8inx 5515 4 only only JJ cord-010092-uftc8inx 5515 5 risk risk NN cord-010092-uftc8inx 5515 6 factor factor NN cord-010092-uftc8inx 5515 7 for for IN cord-010092-uftc8inx 5515 8 thrombosis thrombosis NN cord-010092-uftc8inx 5515 9 was be VBD cord-010092-uftc8inx 5515 10 use use NN cord-010092-uftc8inx 5515 11 of of IN cord-010092-uftc8inx 5515 12 the the DT cord-010092-uftc8inx 5515 13 oral oral JJ cord-010092-uftc8inx 5515 14 contraceptive contraceptive JJ cord-010092-uftc8inx 5515 15 pill pill NN cord-010092-uftc8inx 5515 16 . . . cord-010092-uftc8inx 5516 1 Summary Summary NNP cord-010092-uftc8inx 5516 2 / / SYM cord-010092-uftc8inx 5516 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 5516 4 : : : cord-010092-uftc8inx 5517 1 Rare rare JJ cord-010092-uftc8inx 5517 2 complications complication NNS cord-010092-uftc8inx 5517 3 of of IN cord-010092-uftc8inx 5517 4 blood blood NN cord-010092-uftc8inx 5517 5 donation donation NN cord-010092-uftc8inx 5517 6 , , , cord-010092-uftc8inx 5517 7 like like IN cord-010092-uftc8inx 5517 8 DVT DVT NNP cord-010092-uftc8inx 5517 9 , , , cord-010092-uftc8inx 5517 10 can can MD cord-010092-uftc8inx 5517 11 occur occur VB cord-010092-uftc8inx 5517 12 . . . cord-010092-uftc8inx 5518 1 Superficial superficial JJ cord-010092-uftc8inx 5518 2 venous venous JJ cord-010092-uftc8inx 5518 3 thrombosis thrombosis NN cord-010092-uftc8inx 5518 4 may may MD cord-010092-uftc8inx 5518 5 occasionally occasionally RB cord-010092-uftc8inx 5518 6 progress progress VB cord-010092-uftc8inx 5518 7 into into IN cord-010092-uftc8inx 5518 8 the the DT cord-010092-uftc8inx 5518 9 deeper deep JJR cord-010092-uftc8inx 5518 10 veins vein NNS cord-010092-uftc8inx 5518 11 of of IN cord-010092-uftc8inx 5518 12 the the DT cord-010092-uftc8inx 5518 13 donor donor NN cord-010092-uftc8inx 5518 14 's 's POS cord-010092-uftc8inx 5518 15 arm arm NN cord-010092-uftc8inx 5518 16 but but CC cord-010092-uftc8inx 5518 17 DVT DVT NNP cord-010092-uftc8inx 5518 18 can can MD cord-010092-uftc8inx 5518 19 also also RB cord-010092-uftc8inx 5518 20 occur occur VB cord-010092-uftc8inx 5518 21 without without IN cord-010092-uftc8inx 5518 22 signs sign NNS cord-010092-uftc8inx 5518 23 and and CC cord-010092-uftc8inx 5518 24 symptoms symptom NNS cord-010092-uftc8inx 5518 25 of of IN cord-010092-uftc8inx 5518 26 superficial superficial JJ cord-010092-uftc8inx 5518 27 thrombosis thrombosis NN cord-010092-uftc8inx 5518 28 . . . cord-010092-uftc8inx 5519 1 None none NN cord-010092-uftc8inx 5519 2 of of IN cord-010092-uftc8inx 5519 3 our -PRON- PRP$ cord-010092-uftc8inx 5519 4 patients patient NNS cord-010092-uftc8inx 5519 5 had have VBD cord-010092-uftc8inx 5519 6 any any DT cord-010092-uftc8inx 5519 7 overt overt JJ cord-010092-uftc8inx 5519 8 evidence evidence NN cord-010092-uftc8inx 5519 9 of of IN cord-010092-uftc8inx 5519 10 superficial superficial JJ cord-010092-uftc8inx 5519 11 thrombosis thrombosis NN cord-010092-uftc8inx 5519 12 . . . cord-010092-uftc8inx 5520 1 One one CD cord-010092-uftc8inx 5520 2 patient patient NN cord-010092-uftc8inx 5520 3 in in IN cord-010092-uftc8inx 5520 4 our -PRON- PRP$ cord-010092-uftc8inx 5520 5 series series NN cord-010092-uftc8inx 5520 6 reported report VBD cord-010092-uftc8inx 5520 7 using use VBG cord-010092-uftc8inx 5520 8 oral oral JJ cord-010092-uftc8inx 5520 9 contraceptive contraceptive JJ cord-010092-uftc8inx 5520 10 pill pill NN cord-010092-uftc8inx 5520 11 . . . cord-010092-uftc8inx 5521 1 No no DT cord-010092-uftc8inx 5521 2 other other JJ cord-010092-uftc8inx 5521 3 risk risk NN cord-010092-uftc8inx 5521 4 factors factor NNS cord-010092-uftc8inx 5521 5 for for IN cord-010092-uftc8inx 5521 6 thrombosis thrombosis NN cord-010092-uftc8inx 5521 7 was be VBD cord-010092-uftc8inx 5521 8 forthcoming forthcoming JJ cord-010092-uftc8inx 5521 9 . . . cord-010092-uftc8inx 5522 1 Transfusion transfusion NN cord-010092-uftc8inx 5522 2 services service NNS cord-010092-uftc8inx 5522 3 should should MD cord-010092-uftc8inx 5522 4 encourage encourage VB cord-010092-uftc8inx 5522 5 donors donor NNS cord-010092-uftc8inx 5522 6 to to TO cord-010092-uftc8inx 5522 7 make make VB cord-010092-uftc8inx 5522 8 early early JJ cord-010092-uftc8inx 5522 9 contact contact NN cord-010092-uftc8inx 5522 10 with with IN cord-010092-uftc8inx 5522 11 the the DT cord-010092-uftc8inx 5522 12 Blood Blood NNP cord-010092-uftc8inx 5522 13 service service NN cord-010092-uftc8inx 5522 14 if if IN cord-010092-uftc8inx 5522 15 they -PRON- PRP cord-010092-uftc8inx 5522 16 experience experience VBP cord-010092-uftc8inx 5522 17 arm arm VBP cord-010092-uftc8inx 5522 18 complications complication NNS cord-010092-uftc8inx 5522 19 so so IN cord-010092-uftc8inx 5522 20 that that IN cord-010092-uftc8inx 5522 21 they -PRON- PRP cord-010092-uftc8inx 5522 22 can can MD cord-010092-uftc8inx 5522 23 be be VB cord-010092-uftc8inx 5522 24 investigated investigate VBN cord-010092-uftc8inx 5522 25 and and CC cord-010092-uftc8inx 5522 26 managed manage VBN cord-010092-uftc8inx 5522 27 in in IN cord-010092-uftc8inx 5522 28 a a DT cord-010092-uftc8inx 5522 29 timely timely JJ cord-010092-uftc8inx 5522 30 manner manner NN cord-010092-uftc8inx 5522 31 . . . cord-010092-uftc8inx 5523 1 Staff staff NN cord-010092-uftc8inx 5523 2 dealing deal VBG cord-010092-uftc8inx 5523 3 with with IN cord-010092-uftc8inx 5523 4 such such JJ cord-010092-uftc8inx 5523 5 donors donor NNS cord-010092-uftc8inx 5523 6 must must MD cord-010092-uftc8inx 5523 7 recognise recognise VB cord-010092-uftc8inx 5523 8 the the DT cord-010092-uftc8inx 5523 9 possibility possibility NN cord-010092-uftc8inx 5523 10 of of IN cord-010092-uftc8inx 5523 11 this this DT cord-010092-uftc8inx 5523 12 rare rare JJ cord-010092-uftc8inx 5523 13 complication complication NN cord-010092-uftc8inx 5523 14 , , , cord-010092-uftc8inx 5523 15 explore explore VB cord-010092-uftc8inx 5523 16 other other JJ cord-010092-uftc8inx 5523 17 additional additional JJ cord-010092-uftc8inx 5523 18 contributory contributory JJ cord-010092-uftc8inx 5523 19 factors factor NNS cord-010092-uftc8inx 5523 20 and and CC cord-010092-uftc8inx 5523 21 initiate initiate VB cord-010092-uftc8inx 5523 22 prompt prompt JJ cord-010092-uftc8inx 5523 23 and and CC cord-010092-uftc8inx 5523 24 appropriate appropriate JJ cord-010092-uftc8inx 5523 25 management management NN cord-010092-uftc8inx 5523 26 . . . cord-010092-uftc8inx 5524 1 Background background NN cord-010092-uftc8inx 5524 2 : : : cord-010092-uftc8inx 5525 1 Voluntary voluntary JJ cord-010092-uftc8inx 5525 2 blood blood NN cord-010092-uftc8inx 5525 3 donation donation NN cord-010092-uftc8inx 5525 4 is be VBZ cord-010092-uftc8inx 5525 5 widely widely RB cord-010092-uftc8inx 5525 6 considered consider VBN cord-010092-uftc8inx 5525 7 to to TO cord-010092-uftc8inx 5525 8 be be VB cord-010092-uftc8inx 5525 9 safe safe JJ cord-010092-uftc8inx 5525 10 with with IN cord-010092-uftc8inx 5525 11 very very RB cord-010092-uftc8inx 5525 12 minimum minimum JJ cord-010092-uftc8inx 5525 13 chance chance NN cord-010092-uftc8inx 5525 14 of of IN cord-010092-uftc8inx 5525 15 adverse adverse JJ cord-010092-uftc8inx 5525 16 reaction reaction NN cord-010092-uftc8inx 5525 17 , , , cord-010092-uftc8inx 5525 18 which which WDT cord-010092-uftc8inx 5525 19 may may MD cord-010092-uftc8inx 5525 20 occur occur VB cord-010092-uftc8inx 5525 21 during during IN cord-010092-uftc8inx 5525 22 or or CC cord-010092-uftc8inx 5525 23 after after IN cord-010092-uftc8inx 5525 24 the the DT cord-010092-uftc8inx 5525 25 end end NN cord-010092-uftc8inx 5525 26 of of IN cord-010092-uftc8inx 5525 27 phlebotomy phlebotomy NN cord-010092-uftc8inx 5525 28 procedure procedure NN cord-010092-uftc8inx 5525 29 . . . cord-010092-uftc8inx 5526 1 Aims aim VBZ cord-010092-uftc8inx 5526 2 : : : cord-010092-uftc8inx 5527 1 To to TO cord-010092-uftc8inx 5527 2 find find VB cord-010092-uftc8inx 5527 3 the the DT cord-010092-uftc8inx 5527 4 adverse adverse JJ cord-010092-uftc8inx 5527 5 blood blood NN cord-010092-uftc8inx 5527 6 donor donor NN cord-010092-uftc8inx 5527 7 reaction reaction NN cord-010092-uftc8inx 5527 8 among among IN cord-010092-uftc8inx 5527 9 voluntary voluntary JJ cord-010092-uftc8inx 5527 10 blood blood NN cord-010092-uftc8inx 5527 11 donors donor NNS cord-010092-uftc8inx 5527 12 in in IN cord-010092-uftc8inx 5527 13 tertiary tertiary JJ cord-010092-uftc8inx 5527 14 care care NN cord-010092-uftc8inx 5527 15 hospital hospital NN cord-010092-uftc8inx 5527 16 in in IN cord-010092-uftc8inx 5527 17 Kathmandu Kathmandu NNP cord-010092-uftc8inx 5527 18 Methods Methods NNPS cord-010092-uftc8inx 5527 19 : : : cord-010092-uftc8inx 5527 20 This this DT cord-010092-uftc8inx 5527 21 is be VBZ cord-010092-uftc8inx 5527 22 a a DT cord-010092-uftc8inx 5527 23 prospective prospective JJ cord-010092-uftc8inx 5527 24 study study NN cord-010092-uftc8inx 5527 25 done do VBN cord-010092-uftc8inx 5527 26 among among IN cord-010092-uftc8inx 5527 27 voluntary voluntary JJ cord-010092-uftc8inx 5527 28 blood blood NN cord-010092-uftc8inx 5527 29 donors donor NNS cord-010092-uftc8inx 5527 30 at at IN cord-010092-uftc8inx 5527 31 Grande Grande NNP cord-010092-uftc8inx 5527 32 International International NNP cord-010092-uftc8inx 5527 33 Hospital Hospital NNP cord-010092-uftc8inx 5527 34 , , , cord-010092-uftc8inx 5527 35 Kathmandu Kathmandu NNP cord-010092-uftc8inx 5527 36 , , , cord-010092-uftc8inx 5527 37 Nepal Nepal NNP cord-010092-uftc8inx 5527 38 from from IN cord-010092-uftc8inx 5527 39 February February NNP cord-010092-uftc8inx 5527 40 2013 2013 CD cord-010092-uftc8inx 5527 41 to to IN cord-010092-uftc8inx 5527 42 March March NNP cord-010092-uftc8inx 5527 43 2015 2015 CD cord-010092-uftc8inx 5527 44 . . . cord-010092-uftc8inx 5528 1 The the DT cord-010092-uftc8inx 5528 2 outlines outline NNS cord-010092-uftc8inx 5528 3 of of IN cord-010092-uftc8inx 5528 4 reported report VBN cord-010092-uftc8inx 5528 5 and and CC cord-010092-uftc8inx 5528 6 communicated communicate VBD cord-010092-uftc8inx 5528 7 adverse adverse JJ cord-010092-uftc8inx 5528 8 donor donor NN cord-010092-uftc8inx 5528 9 reaction reaction NN cord-010092-uftc8inx 5528 10 were be VBD cord-010092-uftc8inx 5528 11 also also RB cord-010092-uftc8inx 5528 12 collected collect VBN cord-010092-uftc8inx 5528 13 after after IN cord-010092-uftc8inx 5528 14 the the DT cord-010092-uftc8inx 5528 15 blood blood NN cord-010092-uftc8inx 5528 16 donation donation NN cord-010092-uftc8inx 5528 17 from from IN cord-010092-uftc8inx 5528 18 voluntary voluntary JJ cord-010092-uftc8inx 5528 19 blood blood NN cord-010092-uftc8inx 5528 20 donors donor NNS cord-010092-uftc8inx 5528 21 in in IN cord-010092-uftc8inx 5528 22 different different JJ cord-010092-uftc8inx 5528 23 locations location NNS cord-010092-uftc8inx 5528 24 including include VBG cord-010092-uftc8inx 5528 25 outdoor outdoor JJ cord-010092-uftc8inx 5528 26 and and CC cord-010092-uftc8inx 5528 27 in in IN cord-010092-uftc8inx 5528 28 - - HYPH cord-010092-uftc8inx 5528 29 house house NN cord-010092-uftc8inx 5528 30 blood blood NN cord-010092-uftc8inx 5528 31 donation donation NN cord-010092-uftc8inx 5528 32 drive drive NN cord-010092-uftc8inx 5528 33 Results result NNS cord-010092-uftc8inx 5528 34 : : : cord-010092-uftc8inx 5528 35 In in IN cord-010092-uftc8inx 5528 36 the the DT cord-010092-uftc8inx 5528 37 present present JJ cord-010092-uftc8inx 5528 38 study study NN cord-010092-uftc8inx 5528 39 6,955 6,955 CD cord-010092-uftc8inx 5528 40 whole whole JJ cord-010092-uftc8inx 5528 41 blood blood NN cord-010092-uftc8inx 5528 42 donors donor NNS cord-010092-uftc8inx 5528 43 were be VBD cord-010092-uftc8inx 5528 44 included include VBN cord-010092-uftc8inx 5528 45 , , , cord-010092-uftc8inx 5528 46 during during IN cord-010092-uftc8inx 5528 47 the the DT cord-010092-uftc8inx 5528 48 period period NN cord-010092-uftc8inx 5528 49 of of IN cord-010092-uftc8inx 5528 50 2 2 CD cord-010092-uftc8inx 5528 51 years year NNS cord-010092-uftc8inx 5528 52 , , , cord-010092-uftc8inx 5528 53 105 105 CD cord-010092-uftc8inx 5528 54 ( ( -LRB- cord-010092-uftc8inx 5528 55 1.50 1.50 CD cord-010092-uftc8inx 5528 56 % % NN cord-010092-uftc8inx 5528 57 ) ) -RRB- cord-010092-uftc8inx 5528 58 adverse adverse JJ cord-010092-uftc8inx 5528 59 donor donor NN cord-010092-uftc8inx 5528 60 reactions reaction NNS cord-010092-uftc8inx 5528 61 were be VBD cord-010092-uftc8inx 5528 62 reported report VBN cord-010092-uftc8inx 5528 63 . . . cord-010092-uftc8inx 5529 1 Majority majority NN cord-010092-uftc8inx 5529 2 89 89 CD cord-010092-uftc8inx 5529 3 ( ( -LRB- cord-010092-uftc8inx 5529 4 84.76 84.76 CD cord-010092-uftc8inx 5529 5 % % NN cord-010092-uftc8inx 5529 6 ) ) -RRB- cord-010092-uftc8inx 5529 7 of of IN cord-010092-uftc8inx 5529 8 adverse adverse JJ cord-010092-uftc8inx 5529 9 donor donor NN cord-010092-uftc8inx 5529 10 reactions reaction NNS cord-010092-uftc8inx 5529 11 were be VBD cord-010092-uftc8inx 5529 12 mild mild JJ cord-010092-uftc8inx 5529 13 in in IN cord-010092-uftc8inx 5529 14 nature nature NN cord-010092-uftc8inx 5529 15 such such JJ cord-010092-uftc8inx 5529 16 as as IN cord-010092-uftc8inx 5529 17 , , , cord-010092-uftc8inx 5529 18 sweating sweat VBG cord-010092-uftc8inx 5529 19 ; ; : cord-010092-uftc8inx 5529 20 27 27 CD cord-010092-uftc8inx 5529 21 ( ( -LRB- cord-010092-uftc8inx 5529 22 25.72 25.72 CD cord-010092-uftc8inx 5529 23 % % NN cord-010092-uftc8inx 5529 24 ) ) -RRB- cord-010092-uftc8inx 5529 25 , , , cord-010092-uftc8inx 5529 26 Light light JJ cord-010092-uftc8inx 5529 27 headedness headedness NN cord-010092-uftc8inx 5529 28 ; ; : cord-010092-uftc8inx 5529 29 19(18.09 19(18.09 CD cord-010092-uftc8inx 5529 30 % % NN cord-010092-uftc8inx 5529 31 ) ) -RRB- cord-010092-uftc8inx 5529 32 , , , cord-010092-uftc8inx 5529 33 nausea nausea NN cord-010092-uftc8inx 5529 34 and and CC cord-010092-uftc8inx 5529 35 vomiting vomiting NN cord-010092-uftc8inx 5529 36 ; ; : cord-010092-uftc8inx 5529 37 15(14.28 15(14.28 LS cord-010092-uftc8inx 5529 38 ) ) -RRB- cord-010092-uftc8inx 5529 39 , , , cord-010092-uftc8inx 5529 40 allergy allergy NN cord-010092-uftc8inx 5529 41 and and CC cord-010092-uftc8inx 5529 42 bruises bruise NNS cord-010092-uftc8inx 5529 43 ; ; : cord-010092-uftc8inx 5529 44 11(10.47 11(10.47 CD cord-010092-uftc8inx 5529 45 % % NN cord-010092-uftc8inx 5529 46 ) ) -RRB- cord-010092-uftc8inx 5529 47 , , , cord-010092-uftc8inx 5529 48 sore sore JJ cord-010092-uftc8inx 5529 49 arm arm NN cord-010092-uftc8inx 5529 50 ; ; : cord-010092-uftc8inx 5529 51 9(8.58 9(8.58 CD cord-010092-uftc8inx 5529 52 % % NN cord-010092-uftc8inx 5529 53 ) ) -RRB- cord-010092-uftc8inx 5529 54 and and CC cord-010092-uftc8inx 5529 55 hematoma hematoma NN cord-010092-uftc8inx 5529 56 ; ; : cord-010092-uftc8inx 5529 57 8(7.62 8(7.62 CD cord-010092-uftc8inx 5529 58 % % NN cord-010092-uftc8inx 5529 59 ) ) -RRB- cord-010092-uftc8inx 5529 60 while while IN cord-010092-uftc8inx 5529 61 16 16 CD cord-010092-uftc8inx 5529 62 ( ( -LRB- cord-010092-uftc8inx 5529 63 15.24 15.24 CD cord-010092-uftc8inx 5529 64 % % NN cord-010092-uftc8inx 5529 65 ) ) -RRB- cord-010092-uftc8inx 5529 66 were be VBD cord-010092-uftc8inx 5529 67 severe severe JJ cord-010092-uftc8inx 5529 68 adverse adverse JJ cord-010092-uftc8inx 5529 69 reactions reaction NNS cord-010092-uftc8inx 5529 70 similarly similarly RB cord-010092-uftc8inx 5529 71 , , , cord-010092-uftc8inx 5529 72 anaphylaxis anaphylaxis NN cord-010092-uftc8inx 5529 73 ; ; : cord-010092-uftc8inx 5529 74 11(10.49 11(10.49 CD cord-010092-uftc8inx 5529 75 % % NN cord-010092-uftc8inx 5529 76 ) ) -RRB- cord-010092-uftc8inx 5529 77 , , , cord-010092-uftc8inx 5529 78 loss loss NN cord-010092-uftc8inx 5529 79 of of IN cord-010092-uftc8inx 5529 80 consciousness consciousness NN cord-010092-uftc8inx 5529 81 ; ; : cord-010092-uftc8inx 5529 82 3(2.85 3(2.85 CD cord-010092-uftc8inx 5529 83 % % NN cord-010092-uftc8inx 5529 84 ) ) -RRB- cord-010092-uftc8inx 5529 85 and and CC cord-010092-uftc8inx 5529 86 convulsive convulsive JJ cord-010092-uftc8inx 5529 87 syncope syncope NN cord-010092-uftc8inx 5529 88 ; ; : cord-010092-uftc8inx 5529 89 2(1.90 2(1.90 CD cord-010092-uftc8inx 5529 90 % % NN cord-010092-uftc8inx 5529 91 ) ) -RRB- cord-010092-uftc8inx 5529 92 . . . cord-010092-uftc8inx 5530 1 Markers marker NNS cord-010092-uftc8inx 5530 2 of of IN cord-010092-uftc8inx 5530 3 the the DT cord-010092-uftc8inx 5530 4 adverse adverse JJ cord-010092-uftc8inx 5530 5 donor donor NN cord-010092-uftc8inx 5530 6 reaction reaction NN cord-010092-uftc8inx 5530 7 were be VBD cord-010092-uftc8inx 5530 8 age age NN cord-010092-uftc8inx 5530 9 , , , cord-010092-uftc8inx 5530 10 sex sex NN cord-010092-uftc8inx 5530 11 , , , cord-010092-uftc8inx 5530 12 pulse pulse NN cord-010092-uftc8inx 5530 13 , , , cord-010092-uftc8inx 5530 14 weight weight NN cord-010092-uftc8inx 5530 15 , , , cord-010092-uftc8inx 5530 16 blood blood NN cord-010092-uftc8inx 5530 17 pressure pressure NN cord-010092-uftc8inx 5530 18 and and CC cord-010092-uftc8inx 5530 19 donation donation NN cord-010092-uftc8inx 5530 20 status status NN cord-010092-uftc8inx 5530 21 . . . cord-010092-uftc8inx 5531 1 Age age NN cord-010092-uftc8inx 5531 2 and and CC cord-010092-uftc8inx 5531 3 first first JJ cord-010092-uftc8inx 5531 4 time time NN cord-010092-uftc8inx 5531 5 status status NN cord-010092-uftc8inx 5531 6 were be VBD cord-010092-uftc8inx 5531 7 related relate VBN cord-010092-uftc8inx 5531 8 with with IN cord-010092-uftc8inx 5531 9 significantly significantly RB cord-010092-uftc8inx 5531 10 higher high JJR cord-010092-uftc8inx 5531 11 risk risk NN cord-010092-uftc8inx 5531 12 of of IN cord-010092-uftc8inx 5531 13 adverse adverse JJ cord-010092-uftc8inx 5531 14 reaction reaction NN cord-010092-uftc8inx 5531 15 with with IN cord-010092-uftc8inx 5531 16 18 18 CD cord-010092-uftc8inx 5531 17 - - SYM cord-010092-uftc8inx 5531 18 23 23 CD cord-010092-uftc8inx 5531 19 years year NNS cord-010092-uftc8inx 5531 20 old old JJ cord-010092-uftc8inx 5531 21 at at IN cord-010092-uftc8inx 5531 22 higher high JJR cord-010092-uftc8inx 5531 23 risk risk NN cord-010092-uftc8inx 5531 24 compared compare VBN cord-010092-uftc8inx 5531 25 to to IN cord-010092-uftc8inx 5531 26 24 24 CD cord-010092-uftc8inx 5531 27 - - SYM cord-010092-uftc8inx 5531 28 55 55 CD cord-010092-uftc8inx 5531 29 years year NNS cord-010092-uftc8inx 5531 30 old old JJ cord-010092-uftc8inx 5531 31 . . . cord-010092-uftc8inx 5532 1 First first JJ cord-010092-uftc8inx 5532 2 time time NN cord-010092-uftc8inx 5532 3 donors donor NNS cord-010092-uftc8inx 5532 4 were be VBD cord-010092-uftc8inx 5532 5 at at IN cord-010092-uftc8inx 5532 6 higher high JJR cord-010092-uftc8inx 5532 7 risk risk NN cord-010092-uftc8inx 5532 8 compared compare VBN cord-010092-uftc8inx 5532 9 to to IN cord-010092-uftc8inx 5532 10 repeated repeat VBN cord-010092-uftc8inx 5532 11 volunteer volunteer NN cord-010092-uftc8inx 5532 12 donors donor NNS cord-010092-uftc8inx 5532 13 . . . cord-010092-uftc8inx 5533 1 Summary Summary NNP cord-010092-uftc8inx 5533 2 / / SYM cord-010092-uftc8inx 5533 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 5533 4 : : : cord-010092-uftc8inx 5534 1 The the DT cord-010092-uftc8inx 5534 2 results result NNS cord-010092-uftc8inx 5534 3 of of IN cord-010092-uftc8inx 5534 4 the the DT cord-010092-uftc8inx 5534 5 study study NN cord-010092-uftc8inx 5534 6 are be VBP cord-010092-uftc8inx 5534 7 helpful helpful JJ cord-010092-uftc8inx 5534 8 to to TO cord-010092-uftc8inx 5534 9 identify identify VB cord-010092-uftc8inx 5534 10 and and CC cord-010092-uftc8inx 5534 11 understand understand VB cord-010092-uftc8inx 5534 12 the the DT cord-010092-uftc8inx 5534 13 complication complication NN cord-010092-uftc8inx 5534 14 of of IN cord-010092-uftc8inx 5534 15 adverse adverse JJ cord-010092-uftc8inx 5534 16 donor donor NN cord-010092-uftc8inx 5534 17 reactions reaction NNS cord-010092-uftc8inx 5534 18 though though IN cord-010092-uftc8inx 5534 19 the the DT cord-010092-uftc8inx 5534 20 incidence incidence NN cord-010092-uftc8inx 5534 21 of of IN cord-010092-uftc8inx 5534 22 reactions reaction NNS cord-010092-uftc8inx 5534 23 in in IN cord-010092-uftc8inx 5534 24 the the DT cord-010092-uftc8inx 5534 25 blood blood NN cord-010092-uftc8inx 5534 26 donors donor NNS cord-010092-uftc8inx 5534 27 is be VBZ cord-010092-uftc8inx 5534 28 lower low JJR cord-010092-uftc8inx 5534 29 than than IN cord-010092-uftc8inx 5534 30 in in IN cord-010092-uftc8inx 5534 31 other other JJ cord-010092-uftc8inx 5534 32 studies study NNS cord-010092-uftc8inx 5534 33 . . . cord-010092-uftc8inx 5535 1 Donor donor NN cord-010092-uftc8inx 5535 2 age age NN cord-010092-uftc8inx 5535 3 and and CC cord-010092-uftc8inx 5535 4 donation donation NN cord-010092-uftc8inx 5535 5 status status NN cord-010092-uftc8inx 5535 6 were be VBD cord-010092-uftc8inx 5535 7 strong strong JJ cord-010092-uftc8inx 5535 8 possibilities possibility NNS cord-010092-uftc8inx 5535 9 of of IN cord-010092-uftc8inx 5535 10 complications complication NNS cord-010092-uftc8inx 5535 11 . . . cord-010092-uftc8inx 5536 1 Background background NN cord-010092-uftc8inx 5536 2 : : : cord-010092-uftc8inx 5537 1 Blood blood NN cord-010092-uftc8inx 5537 2 donors donor NNS cord-010092-uftc8inx 5537 3 with with IN cord-010092-uftc8inx 5537 4 pollen pollen NN cord-010092-uftc8inx 5537 5 - - HYPH cord-010092-uftc8inx 5537 6 induced induce VBN cord-010092-uftc8inx 5537 7 allergy allergy NN cord-010092-uftc8inx 5537 8 and and CC cord-010092-uftc8inx 5537 9 asthma asthma NN cord-010092-uftc8inx 5537 10 must must MD cord-010092-uftc8inx 5537 11 often often RB cord-010092-uftc8inx 5537 12 refrain refrain VB cord-010092-uftc8inx 5537 13 from from IN cord-010092-uftc8inx 5537 14 donation donation NN cord-010092-uftc8inx 5537 15 in in IN cord-010092-uftc8inx 5537 16 pollen pollen NN cord-010092-uftc8inx 5537 17 season season NN cord-010092-uftc8inx 5537 18 despite despite IN cord-010092-uftc8inx 5537 19 medication medication NN cord-010092-uftc8inx 5537 20 , , , cord-010092-uftc8inx 5537 21 because because IN cord-010092-uftc8inx 5537 22 of of IN cord-010092-uftc8inx 5537 23 symptom symptom NN cord-010092-uftc8inx 5537 24 severity severity NN cord-010092-uftc8inx 5537 25 or or CC cord-010092-uftc8inx 5537 26 similarity similarity NN cord-010092-uftc8inx 5537 27 to to IN cord-010092-uftc8inx 5537 28 airways airway NNS cord-010092-uftc8inx 5537 29 infection infection NN cord-010092-uftc8inx 5537 30 . . . cord-010092-uftc8inx 5538 1 Extracts extract NNS cord-010092-uftc8inx 5538 2 of of IN cord-010092-uftc8inx 5538 3 the the DT cord-010092-uftc8inx 5538 4 medicinal medicinal JJ cord-010092-uftc8inx 5538 5 mushroom mushroom NN cord-010092-uftc8inx 5538 6 Agaricus Agaricus NNP cord-010092-uftc8inx 5538 7 blazei blazei NN cord-010092-uftc8inx 5538 8 Murill Murill NNP cord-010092-uftc8inx 5538 9 ( ( -LRB- cord-010092-uftc8inx 5538 10 AbM AbM NNP cord-010092-uftc8inx 5538 11 ) ) -RRB- cord-010092-uftc8inx 5538 12 given give VBN cord-010092-uftc8inx 5538 13 orally orally RB cord-010092-uftc8inx 5538 14 have have VBP cord-010092-uftc8inx 5538 15 been be VBN cord-010092-uftc8inx 5538 16 found find VBN cord-010092-uftc8inx 5538 17 to to TO cord-010092-uftc8inx 5538 18 reduce reduce VB cord-010092-uftc8inx 5538 19 IgE IgE NNP cord-010092-uftc8inx 5538 20 anti anti JJ cord-010092-uftc8inx 5538 21 - - JJ cord-010092-uftc8inx 5538 22 ovalbumin ovalbumin JJ cord-010092-uftc8inx 5538 23 levels level NNS cord-010092-uftc8inx 5538 24 and and CC cord-010092-uftc8inx 5538 25 ameliorate ameliorate VB cord-010092-uftc8inx 5538 26 the the DT cord-010092-uftc8inx 5538 27 skewed skewed JJ cord-010092-uftc8inx 5538 28 Th1 th1 NN cord-010092-uftc8inx 5538 29 / / SYM cord-010092-uftc8inx 5538 30 Th2 th2 CD cord-010092-uftc8inx 5538 31 cytokine cytokine NN cord-010092-uftc8inx 5538 32 balance balance NN cord-010092-uftc8inx 5538 33 in in IN cord-010092-uftc8inx 5538 34 mice mouse NNS cord-010092-uftc8inx 5538 35 sensitized sensitize VBN cord-010092-uftc8inx 5538 36 to to IN cord-010092-uftc8inx 5538 37 ovalbumin ovalbumin FW cord-010092-uftc8inx 5538 38 ( ( -LRB- cord-010092-uftc8inx 5538 39 Takimoto Takimoto NNP cord-010092-uftc8inx 5538 40 , , , cord-010092-uftc8inx 5538 41 Immunopharm Immunopharm NNP cord-010092-uftc8inx 5538 42 Immunotox Immunotox NNP cord-010092-uftc8inx 5538 43 , , , cord-010092-uftc8inx 5538 44 2008 2008 CD cord-010092-uftc8inx 5538 45 ; ; : cord-010092-uftc8inx 5538 46 Ellertsen Ellertsen NNP cord-010092-uftc8inx 5538 47 & & CC cord-010092-uftc8inx 5538 48 Hetland Hetland NNP cord-010092-uftc8inx 5538 49 , , , cord-010092-uftc8inx 5538 50 Clin Clin NNP cord-010092-uftc8inx 5538 51 Mol Mol NNP cord-010092-uftc8inx 5538 52 Allergy allergy NN cord-010092-uftc8inx 5538 53 , , , cord-010092-uftc8inx 5538 54 2009 2009 CD cord-010092-uftc8inx 5538 55 ) ) -RRB- cord-010092-uftc8inx 5538 56 . . . cord-010092-uftc8inx 5539 1 Aims aim VBZ cord-010092-uftc8inx 5539 2 : : : cord-010092-uftc8inx 5540 1 The the DT cord-010092-uftc8inx 5540 2 objective objective NN cord-010092-uftc8inx 5540 3 was be VBD cord-010092-uftc8inx 5540 4 now now RB cord-010092-uftc8inx 5540 5 to to TO cord-010092-uftc8inx 5540 6 examine examine VB cord-010092-uftc8inx 5540 7 whether whether IN cord-010092-uftc8inx 5540 8 supplementation supplementation NN cord-010092-uftc8inx 5540 9 with with IN cord-010092-uftc8inx 5540 10 the the DT cord-010092-uftc8inx 5540 11 AbMbased AbMbased NNP cord-010092-uftc8inx 5540 12 extract extract NN cord-010092-uftc8inx 5540 13 that that IN cord-010092-uftc8inx 5540 14 we -PRON- PRP cord-010092-uftc8inx 5540 15 used use VBD cord-010092-uftc8inx 5540 16 in in IN cord-010092-uftc8inx 5540 17 the the DT cord-010092-uftc8inx 5540 18 mouse mouse NN cord-010092-uftc8inx 5540 19 model model NN cord-010092-uftc8inx 5540 20 for for IN cord-010092-uftc8inx 5540 21 allergy allergy NN cord-010092-uftc8inx 5540 22 , , , cord-010092-uftc8inx 5540 23 could could MD cord-010092-uftc8inx 5540 24 alleviate alleviate VB cord-010092-uftc8inx 5540 25 allergy allergy NN cord-010092-uftc8inx 5540 26 and and CC cord-010092-uftc8inx 5540 27 asthma asthma NN cord-010092-uftc8inx 5540 28 in in IN cord-010092-uftc8inx 5540 29 blood blood NN cord-010092-uftc8inx 5540 30 donors donor NNS cord-010092-uftc8inx 5540 31 by by IN cord-010092-uftc8inx 5540 32 reducing reduce VBG cord-010092-uftc8inx 5540 33 specific specific JJ cord-010092-uftc8inx 5540 34 IgE IgE NNP cord-010092-uftc8inx 5540 35 levels level NNS cord-010092-uftc8inx 5540 36 and and CC cord-010092-uftc8inx 5540 37 basophil basophil NNP cord-010092-uftc8inx 5540 38 sensitization sensitization NN cord-010092-uftc8inx 5540 39 . . . cord-010092-uftc8inx 5541 1 Methods method NNS cord-010092-uftc8inx 5541 2 : : : cord-010092-uftc8inx 5541 3 Sixty sixty CD cord-010092-uftc8inx 5541 4 donors donor NNS cord-010092-uftc8inx 5541 5 at at IN cord-010092-uftc8inx 5541 6 Oslo Oslo NNP cord-010092-uftc8inx 5541 7 Blood Blood NNP cord-010092-uftc8inx 5541 8 Bank Bank NNP cord-010092-uftc8inx 5541 9 with with IN cord-010092-uftc8inx 5541 10 self self NN cord-010092-uftc8inx 5541 11 - - HYPH cord-010092-uftc8inx 5541 12 reported report VBN cord-010092-uftc8inx 5541 13 birch birch NN cord-010092-uftc8inx 5541 14 pollen pollen NN cord-010092-uftc8inx 5541 15 allergy allergy NN cord-010092-uftc8inx 5541 16 and/or and/or CC cord-010092-uftc8inx 5541 17 asthma asthma NN cord-010092-uftc8inx 5541 18 were be VBD cord-010092-uftc8inx 5541 19 recruited recruit VBN cord-010092-uftc8inx 5541 20 and and CC cord-010092-uftc8inx 5541 21 randomized randomize VBN cord-010092-uftc8inx 5541 22 in in IN cord-010092-uftc8inx 5541 23 a a DT cord-010092-uftc8inx 5541 24 double double RB cord-010092-uftc8inx 5541 25 - - HYPH cord-010092-uftc8inx 5541 26 blinded blinded JJ cord-010092-uftc8inx 5541 27 , , , cord-010092-uftc8inx 5541 28 placebo placebo NN cord-010092-uftc8inx 5541 29 - - HYPH cord-010092-uftc8inx 5541 30 controlled control VBN cord-010092-uftc8inx 5541 31 study study NN cord-010092-uftc8inx 5541 32 with with IN cord-010092-uftc8inx 5541 33 oral oral JJ cord-010092-uftc8inx 5541 34 supplementation supplementation NN cord-010092-uftc8inx 5541 35 for for IN cord-010092-uftc8inx 5541 36 7 7 CD cord-010092-uftc8inx 5541 37 weeks week NNS cord-010092-uftc8inx 5541 38 before before IN cord-010092-uftc8inx 5541 39 the the DT cord-010092-uftc8inx 5541 40 birch birch NN cord-010092-uftc8inx 5541 41 pollen pollen NN cord-010092-uftc8inx 5541 42 season season NN cord-010092-uftc8inx 5541 43 with with IN cord-010092-uftc8inx 5541 44 the the DT cord-010092-uftc8inx 5541 45 AbM AbM NNP cord-010092-uftc8inx 5541 46 - - HYPH cord-010092-uftc8inx 5541 47 based base VBN cord-010092-uftc8inx 5541 48 extract extract NN cord-010092-uftc8inx 5541 49 Andosan Andosan NNP cord-010092-uftc8inx 5541 50 TM TM NNP cord-010092-uftc8inx 5541 51 ( ( -LRB- cord-010092-uftc8inx 5541 52 Immunopharma Immunopharma NNP cord-010092-uftc8inx 5541 53 , , , cord-010092-uftc8inx 5541 54 Oslo Oslo NNP cord-010092-uftc8inx 5541 55 , , , cord-010092-uftc8inx 5541 56 Norway Norway NNP cord-010092-uftc8inx 5541 57 ) ) -RRB- cord-010092-uftc8inx 5541 58 . . . cord-010092-uftc8inx 5542 1 This this DT cord-010092-uftc8inx 5542 2 is be VBZ cord-010092-uftc8inx 5542 3 a a DT cord-010092-uftc8inx 5542 4 water water NN cord-010092-uftc8inx 5542 5 extract extract NN cord-010092-uftc8inx 5542 6 of of IN cord-010092-uftc8inx 5542 7 the the DT cord-010092-uftc8inx 5542 8 Bacidomycetes Bacidomycetes NNP cord-010092-uftc8inx 5542 9 mushrooms mushroom NNS cord-010092-uftc8inx 5542 10 AbM AbM NNP cord-010092-uftc8inx 5542 11 ( ( -LRB- cord-010092-uftc8inx 5542 12 82 82 CD cord-010092-uftc8inx 5542 13 % % NN cord-010092-uftc8inx 5542 14 ) ) -RRB- cord-010092-uftc8inx 5542 15 , , , cord-010092-uftc8inx 5542 16 Hericeum Hericeum NNP cord-010092-uftc8inx 5542 17 erinaceus erinaceus NN cord-010092-uftc8inx 5542 18 and and CC cord-010092-uftc8inx 5542 19 Grifola Grifola NNP cord-010092-uftc8inx 5542 20 frondosa frondosa NNP cord-010092-uftc8inx 5542 21 . . . cord-010092-uftc8inx 5543 1 The the DT cord-010092-uftc8inx 5543 2 participants participant NNS cord-010092-uftc8inx 5543 3 filled fill VBN cord-010092-uftc8inx 5543 4 in in IN cord-010092-uftc8inx 5543 5 questionnaires questionnaire NNS cord-010092-uftc8inx 5543 6 for for IN cord-010092-uftc8inx 5543 7 allergic allergic JJ cord-010092-uftc8inx 5543 8 conjunctivitis conjunctivitis NN cord-010092-uftc8inx 5543 9 & & CC cord-010092-uftc8inx 5543 10 rhinitis rhinitis NN cord-010092-uftc8inx 5543 11 , , , cord-010092-uftc8inx 5543 12 asthma asthma NN cord-010092-uftc8inx 5543 13 and and CC cord-010092-uftc8inx 5543 14 medication medication NN cord-010092-uftc8inx 5543 15 . . . cord-010092-uftc8inx 5544 1 Serum serum NN cord-010092-uftc8inx 5544 2 IgE IgE NNP cord-010092-uftc8inx 5544 3 ( ( -LRB- cord-010092-uftc8inx 5544 4 ImmunoCAP ImmunoCAP NNP cord-010092-uftc8inx 5544 5 â â , cord-010092-uftc8inx 5544 6 , , , cord-010092-uftc8inx 5544 7 ImmunoDiagnostics ImmunoDiagnostics NNP cord-010092-uftc8inx 5544 8 , , , cord-010092-uftc8inx 5544 9 Sweden Sweden NNP cord-010092-uftc8inx 5544 10 ) ) -RRB- cord-010092-uftc8inx 5544 11 and and CC cord-010092-uftc8inx 5545 1 Bet bet VB cord-010092-uftc8inx 5546 1 v v LS cord-010092-uftc8inx 5546 2 1-induced 1-induced CD cord-010092-uftc8inx 5546 3 basophil basophil NNP cord-010092-uftc8inx 5546 4 activation activation NN cord-010092-uftc8inx 5546 5 in in IN cord-010092-uftc8inx 5546 6 whole whole JJ cord-010092-uftc8inx 5546 7 blood blood NN cord-010092-uftc8inx 5546 8 determined determine VBN cord-010092-uftc8inx 5546 9 by by IN cord-010092-uftc8inx 5546 10 CD63 CD63 NNP cord-010092-uftc8inx 5546 11 expression expression NN cord-010092-uftc8inx 5546 12 in in IN cord-010092-uftc8inx 5546 13 a a DT cord-010092-uftc8inx 5546 14 flow flow NN cord-010092-uftc8inx 5546 15 cytometer cytometer NN cord-010092-uftc8inx 5546 16 ( ( -LRB- cord-010092-uftc8inx 5546 17 Flow flow JJ cord-010092-uftc8inx 5546 18 CAST cast NN cord-010092-uftc8inx 5546 19 â â NN cord-010092-uftc8inx 5546 20 , , , cord-010092-uftc8inx 5546 21 B€ B€ NNP cord-010092-uftc8inx 5546 22 uhlmann uhlmann NNP cord-010092-uftc8inx 5546 23 Lab Lab NNP cord-010092-uftc8inx 5546 24 AG AG NNP cord-010092-uftc8inx 5546 25 , , , cord-010092-uftc8inx 5546 26 Switzerland Switzerland NNP cord-010092-uftc8inx 5546 27 ) ) -RRB- cord-010092-uftc8inx 5546 28 , , , cord-010092-uftc8inx 5546 29 were be VBD cord-010092-uftc8inx 5546 30 analyzed analyze VBN cord-010092-uftc8inx 5546 31 before before IN cord-010092-uftc8inx 5546 32 and and CC cord-010092-uftc8inx 5546 33 after after IN cord-010092-uftc8inx 5546 34 the the DT cord-010092-uftc8inx 5546 35 pollen pollen NN cord-010092-uftc8inx 5546 36 season season NN cord-010092-uftc8inx 5546 37 . . . cord-010092-uftc8inx 5547 1 ( ( -LRB- cord-010092-uftc8inx 5547 2 Trial trial NN cord-010092-uftc8inx 5547 3 record record NN cord-010092-uftc8inx 5547 4 : : : cord-010092-uftc8inx 5548 1 NCT03198455 NCT03198455 NNP cord-010092-uftc8inx 5548 2 , , , cord-010092-uftc8inx 5548 3 Clinical.Trials.gov Clinical.Trials.gov NNP cord-010092-uftc8inx 5548 4 ) ) -RRB- cord-010092-uftc8inx 5548 5 . . . cord-010092-uftc8inx 5549 1 Results result NNS cord-010092-uftc8inx 5549 2 : : : cord-010092-uftc8inx 5550 1 There there EX cord-010092-uftc8inx 5550 2 was be VBD cord-010092-uftc8inx 5550 3 significant significant JJ cord-010092-uftc8inx 5550 4 reduction reduction NN cord-010092-uftc8inx 5550 5 in in IN cord-010092-uftc8inx 5550 6 allover allover NN cord-010092-uftc8inx 5550 7 allergy allergy NN cord-010092-uftc8inx 5550 8 - - HYPH cord-010092-uftc8inx 5550 9 related relate VBN cord-010092-uftc8inx 5550 10 ailments ailment NNS cord-010092-uftc8inx 5550 11 and and CC cord-010092-uftc8inx 5550 12 types type NNS cord-010092-uftc8inx 5550 13 of of IN cord-010092-uftc8inx 5550 14 allergy allergy NN cord-010092-uftc8inx 5550 15 medication medication NN cord-010092-uftc8inx 5550 16 used use VBN cord-010092-uftc8inx 5550 17 in in IN cord-010092-uftc8inx 5550 18 the the DT cord-010092-uftc8inx 5550 19 AbM abm JJ cord-010092-uftc8inx 5550 20 extract extract NN cord-010092-uftc8inx 5550 21 compared compare VBN cord-010092-uftc8inx 5550 22 with with IN cord-010092-uftc8inx 5550 23 placebo placebo NN cord-010092-uftc8inx 5550 24 group group NN cord-010092-uftc8inx 5550 25 during during IN cord-010092-uftc8inx 5550 26 the the DT cord-010092-uftc8inx 5550 27 pollen pollen NN cord-010092-uftc8inx 5550 28 season season NN cord-010092-uftc8inx 5550 29 and and CC cord-010092-uftc8inx 5550 30 no no DT cord-010092-uftc8inx 5550 31 side side NN cord-010092-uftc8inx 5550 32 effects effect NNS cord-010092-uftc8inx 5550 33 . . . cord-010092-uftc8inx 5551 1 Also also RB cord-010092-uftc8inx 5551 2 , , , cord-010092-uftc8inx 5551 3 AbM AbM NNP cord-010092-uftc8inx 5551 4 treated treat VBN cord-010092-uftc8inx 5551 5 asthmatics asthmatic NNS cord-010092-uftc8inx 5551 6 had have VBD cord-010092-uftc8inx 5551 7 fewer few JJR cord-010092-uftc8inx 5551 8 symptoms symptom NNS cord-010092-uftc8inx 5551 9 and and CC cord-010092-uftc8inx 5551 10 used use VBD cord-010092-uftc8inx 5551 11 less less JJR cord-010092-uftc8inx 5551 12 medication medication NN cord-010092-uftc8inx 5551 13 than than IN cord-010092-uftc8inx 5551 14 controls control NNS cord-010092-uftc8inx 5551 15 . . . cord-010092-uftc8inx 5552 1 In in IN cord-010092-uftc8inx 5552 2 the the DT cord-010092-uftc8inx 5552 3 AbM AbM NNP cord-010092-uftc8inx 5552 4 group group NN cord-010092-uftc8inx 5552 5 , , , cord-010092-uftc8inx 5552 6 serum serum NN cord-010092-uftc8inx 5552 7 levels level NNS cord-010092-uftc8inx 5552 8 of of IN cord-010092-uftc8inx 5552 9 specific specific JJ cord-010092-uftc8inx 5552 10 IgE IgE NNP cord-010092-uftc8inx 5552 11 anti anti NNP cord-010092-uftc8inx 5552 12 - - JJ cord-010092-uftc8inx 5552 13 Bet Bet NNP cord-010092-uftc8inx 5552 14 v v NN cord-010092-uftc8inx 5552 15 1 1 CD cord-010092-uftc8inx 5552 16 and and CC cord-010092-uftc8inx 5552 17 anti anti JJ cord-010092-uftc8inx 5552 18 - - NNP cord-010092-uftc8inx 5552 19 t3 t3 NNP cord-010092-uftc8inx 5552 20 , , , cord-010092-uftc8inx 5552 21 were be VBD cord-010092-uftc8inx 5552 22 significantly significantly RB cord-010092-uftc8inx 5552 23 reduced reduce VBN cord-010092-uftc8inx 5552 24 during during IN cord-010092-uftc8inx 5552 25 the the DT cord-010092-uftc8inx 5552 26 pollen pollen NN cord-010092-uftc8inx 5552 27 season season NN cord-010092-uftc8inx 5552 28 as as IN cord-010092-uftc8inx 5552 29 compared compare VBN cord-010092-uftc8inx 5552 30 with with IN cord-010092-uftc8inx 5552 31 levels level NNS cord-010092-uftc8inx 5552 32 in in IN cord-010092-uftc8inx 5552 33 the the DT cord-010092-uftc8inx 5552 34 placebo placebo NN cord-010092-uftc8inx 5552 35 group group NN cord-010092-uftc8inx 5552 36 . . . cord-010092-uftc8inx 5553 1 Whereas whereas IN cord-010092-uftc8inx 5553 2 the the DT cord-010092-uftc8inx 5553 3 maximal maximal JJ cord-010092-uftc8inx 5553 4 allergen allergen NN cord-010092-uftc8inx 5553 5 concentrations concentration NNS cord-010092-uftc8inx 5553 6 needed need VBN cord-010092-uftc8inx 5553 7 for for IN cord-010092-uftc8inx 5553 8 eliciting elicit VBG cord-010092-uftc8inx 5553 9 basophil basophil NNP cord-010092-uftc8inx 5553 10 activation activation NN cord-010092-uftc8inx 5553 11 before before IN cord-010092-uftc8inx 5553 12 the the DT cord-010092-uftc8inx 5553 13 season season NN cord-010092-uftc8inx 5553 14 changed change VBD cord-010092-uftc8inx 5553 15 significantly significantly RB cord-010092-uftc8inx 5553 16 to to TO cord-010092-uftc8inx 5553 17 lower lower VB cord-010092-uftc8inx 5553 18 concentrations concentration NNS cord-010092-uftc8inx 5553 19 ( ( -LRB- cord-010092-uftc8inx 5553 20 i.e. i.e. FW cord-010092-uftc8inx 5553 21 enhanced enhanced JJ cord-010092-uftc8inx 5553 22 sensitization sensitization NN cord-010092-uftc8inx 5553 23 ) ) -RRB- cord-010092-uftc8inx 5553 24 after after IN cord-010092-uftc8inx 5553 25 the the DT cord-010092-uftc8inx 5553 26 season season NN cord-010092-uftc8inx 5553 27 in in IN cord-010092-uftc8inx 5553 28 the the DT cord-010092-uftc8inx 5553 29 placebo placebo NN cord-010092-uftc8inx 5553 30 group group NN cord-010092-uftc8inx 5553 31 , , , cord-010092-uftc8inx 5553 32 these these DT cord-010092-uftc8inx 5553 33 concentrations concentration NNS cord-010092-uftc8inx 5553 34 remained remain VBD cord-010092-uftc8inx 5553 35 similar similar JJ cord-010092-uftc8inx 5553 36 in in IN cord-010092-uftc8inx 5553 37 the the DT cord-010092-uftc8inx 5553 38 group group NN cord-010092-uftc8inx 5553 39 given give VBN cord-010092-uftc8inx 5553 40 the the DT cord-010092-uftc8inx 5553 41 mushroom mushroom NN cord-010092-uftc8inx 5553 42 extract extract NN cord-010092-uftc8inx 5553 43 . . . cord-010092-uftc8inx 5554 1 Summary Summary NNP cord-010092-uftc8inx 5554 2 / / SYM cord-010092-uftc8inx 5554 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 5554 4 : : : cord-010092-uftc8inx 5555 1 Oral oral JJ cord-010092-uftc8inx 5555 2 pre pre JJ cord-010092-uftc8inx 5555 3 - - JJ cord-010092-uftc8inx 5555 4 seasonal seasonal JJ cord-010092-uftc8inx 5555 5 supplementation supplementation NN cord-010092-uftc8inx 5555 6 with with IN cord-010092-uftc8inx 5555 7 an an DT cord-010092-uftc8inx 5555 8 AbM abm NN cord-010092-uftc8inx 5555 9 - - HYPH cord-010092-uftc8inx 5555 10 based base VBN cord-010092-uftc8inx 5555 11 extract extract NN cord-010092-uftc8inx 5555 12 for for IN cord-010092-uftc8inx 5555 13 2 2 CD cord-010092-uftc8inx 5555 14 months month NNS cord-010092-uftc8inx 5555 15 reduced reduce VBN cord-010092-uftc8inx 5555 16 general general JJ cord-010092-uftc8inx 5555 17 allergy allergy NN cord-010092-uftc8inx 5555 18 ailments ailment NNS cord-010092-uftc8inx 5555 19 , , , cord-010092-uftc8inx 5555 20 asthma asthma NN cord-010092-uftc8inx 5555 21 symptoms symptom NNS cord-010092-uftc8inx 5555 22 and and CC cord-010092-uftc8inx 5555 23 medication medication NN cord-010092-uftc8inx 5555 24 in in IN cord-010092-uftc8inx 5555 25 blood blood NN cord-010092-uftc8inx 5555 26 donors donor NNS cord-010092-uftc8inx 5555 27 with with IN cord-010092-uftc8inx 5555 28 birch birch NN cord-010092-uftc8inx 5555 29 pollen pollen NN cord-010092-uftc8inx 5555 30 - - HYPH cord-010092-uftc8inx 5555 31 induced induce VBN cord-010092-uftc8inx 5555 32 allergy allergy NN cord-010092-uftc8inx 5555 33 and and CC cord-010092-uftc8inx 5555 34 asthma asthma NN cord-010092-uftc8inx 5555 35 during during IN cord-010092-uftc8inx 5555 36 the the DT cord-010092-uftc8inx 5555 37 pollen pollen NN cord-010092-uftc8inx 5555 38 season season NN cord-010092-uftc8inx 5555 39 . . . cord-010092-uftc8inx 5556 1 This this DT cord-010092-uftc8inx 5556 2 was be VBD cord-010092-uftc8inx 5556 3 due due JJ cord-010092-uftc8inx 5556 4 to to IN cord-010092-uftc8inx 5556 5 reduced reduce VBN cord-010092-uftc8inx 5556 6 specific specific JJ cord-010092-uftc8inx 5556 7 IgE ige JJ cord-010092-uftc8inx 5556 8 levels level NNS cord-010092-uftc8inx 5556 9 and and CC cord-010092-uftc8inx 5556 10 basophils basophil NNS cord-010092-uftc8inx 5556 11 rendered render VBN cord-010092-uftc8inx 5556 12 less less RBR cord-010092-uftc8inx 5556 13 sensitive sensitive JJ cord-010092-uftc8inx 5556 14 to to IN cord-010092-uftc8inx 5556 15 allergen allergen NN cord-010092-uftc8inx 5556 16 activation activation NN cord-010092-uftc8inx 5556 17 . . . cord-010092-uftc8inx 5557 1 The the DT cord-010092-uftc8inx 5557 2 study study NN cord-010092-uftc8inx 5557 3 suggests suggest VBZ cord-010092-uftc8inx 5557 4 that that IN cord-010092-uftc8inx 5557 5 supplementation supplementation NN cord-010092-uftc8inx 5557 6 with with IN cord-010092-uftc8inx 5557 7 AbM AbM NNP cord-010092-uftc8inx 5557 8 mushroom mushroom NN cord-010092-uftc8inx 5557 9 extract extract NN cord-010092-uftc8inx 5557 10 can can MD cord-010092-uftc8inx 5557 11 have have VB cord-010092-uftc8inx 5557 12 prophylactic prophylactic JJ cord-010092-uftc8inx 5557 13 effect effect NN cord-010092-uftc8inx 5557 14 on on IN cord-010092-uftc8inx 5557 15 aeroallergen aeroallergen NN cord-010092-uftc8inx 5557 16 - - HYPH cord-010092-uftc8inx 5557 17 induced induce VBN cord-010092-uftc8inx 5557 18 allergy allergy NN cord-010092-uftc8inx 5557 19 and and CC cord-010092-uftc8inx 5557 20 asthma asthma NN cord-010092-uftc8inx 5557 21 in in IN cord-010092-uftc8inx 5557 22 blood blood NN cord-010092-uftc8inx 5557 23 donors donor NNS cord-010092-uftc8inx 5557 24 . . . cord-010092-uftc8inx 5558 1 It -PRON- PRP cord-010092-uftc8inx 5558 2 may may MD cord-010092-uftc8inx 5558 3 therefore therefore RB cord-010092-uftc8inx 5558 4 reduce reduce VB cord-010092-uftc8inx 5558 5 such such JJ cord-010092-uftc8inx 5558 6 ailments ailment NNS cord-010092-uftc8inx 5558 7 in in IN cord-010092-uftc8inx 5558 8 affected affect VBN cord-010092-uftc8inx 5558 9 blood blood NN cord-010092-uftc8inx 5558 10 donors donor NNS cord-010092-uftc8inx 5558 11 and and CC cord-010092-uftc8inx 5558 12 impact impact NN cord-010092-uftc8inx 5558 13 blood blood NN cord-010092-uftc8inx 5558 14 donations donation NNS cord-010092-uftc8inx 5558 15 in in IN cord-010092-uftc8inx 5558 16 the the DT cord-010092-uftc8inx 5558 17 pollen pollen NN cord-010092-uftc8inx 5558 18 season season NN cord-010092-uftc8inx 5558 19 . . . cord-010092-uftc8inx 5559 1 Results result NNS cord-010092-uftc8inx 5559 2 : : : cord-010092-uftc8inx 5560 1 DHV DHV NNP cord-010092-uftc8inx 5560 2 started start VBD cord-010092-uftc8inx 5560 3 in in IN cord-010092-uftc8inx 5560 4 20/9/2014 20/9/2014 CD cord-010092-uftc8inx 5560 5 . . . cord-010092-uftc8inx 5561 1 The the DT cord-010092-uftc8inx 5561 2 data datum NNS cord-010092-uftc8inx 5561 3 presented present VBN cord-010092-uftc8inx 5561 4 in in IN cord-010092-uftc8inx 5561 5 this this DT cord-010092-uftc8inx 5561 6 abstract abstract NN cord-010092-uftc8inx 5561 7 is be VBZ cord-010092-uftc8inx 5561 8 till till IN cord-010092-uftc8inx 5561 9 28/2/ 28/2/ CD cord-010092-uftc8inx 5561 10 2019 2019 CD cord-010092-uftc8inx 5561 11 . . . cord-010092-uftc8inx 5562 1 Data Data NNP cord-010092-uftc8inx 5562 2 is be VBZ cord-010092-uftc8inx 5562 3 collected collect VBN cord-010092-uftc8inx 5562 4 from from IN cord-010092-uftc8inx 5562 5 total total NN cord-010092-uftc8inx 5562 6 of of IN cord-010092-uftc8inx 5562 7 114475 114475 CD cord-010092-uftc8inx 5562 8 blood blood NN cord-010092-uftc8inx 5562 9 donors donor NNS cord-010092-uftc8inx 5562 10 ( ( -LRB- cord-010092-uftc8inx 5562 11 86.67 86.67 CD cord-010092-uftc8inx 5562 12 % % NN cord-010092-uftc8inx 5562 13 male male JJ cord-010092-uftc8inx 5562 14 donors donor NNS cord-010092-uftc8inx 5562 15 and and CC cord-010092-uftc8inx 5562 16 13.33 13.33 CD cord-010092-uftc8inx 5562 17 % % NN cord-010092-uftc8inx 5562 18 female female JJ cord-010092-uftc8inx 5562 19 donors donor NNS cord-010092-uftc8inx 5562 20 ) ) -RRB- cord-010092-uftc8inx 5562 21 . . . cord-010092-uftc8inx 5563 1 Repeat repeat NN cord-010092-uftc8inx 5563 2 donors donor NNS cord-010092-uftc8inx 5563 3 accounted account VBD cord-010092-uftc8inx 5563 4 for for IN cord-010092-uftc8inx 5563 5 59.34 59.34 CD cord-010092-uftc8inx 5563 6 % % NN cord-010092-uftc8inx 5563 7 against against IN cord-010092-uftc8inx 5563 8 40.66 40.66 CD cord-010092-uftc8inx 5563 9 % % NN cord-010092-uftc8inx 5563 10 of of IN cord-010092-uftc8inx 5563 11 first first JJ cord-010092-uftc8inx 5563 12 time time NN cord-010092-uftc8inx 5563 13 donors donor NNS cord-010092-uftc8inx 5563 14 . . . cord-010092-uftc8inx 5564 1 Of of IN cord-010092-uftc8inx 5564 2 the the DT cord-010092-uftc8inx 5564 3 total total JJ cord-010092-uftc8inx 5564 4 number number NN cord-010092-uftc8inx 5564 5 of of IN cord-010092-uftc8inx 5564 6 donor donor NN cord-010092-uftc8inx 5564 7 adverse adverse JJ cord-010092-uftc8inx 5564 8 events event NNS cord-010092-uftc8inx 5564 9 recorded record VBN cord-010092-uftc8inx 5564 10 , , , cord-010092-uftc8inx 5564 11 2.73 2.73 CD cord-010092-uftc8inx 5564 12 % % NN cord-010092-uftc8inx 5564 13 ( ( -LRB- cord-010092-uftc8inx 5564 14 2633 2633 CD cord-010092-uftc8inx 5564 15 ) ) -RRB- cord-010092-uftc8inx 5564 16 reported report VBD cord-010092-uftc8inx 5564 17 for for IN cord-010092-uftc8inx 5564 18 male male JJ cord-010092-uftc8inx 5564 19 donors donor NNS cord-010092-uftc8inx 5564 20 and and CC cord-010092-uftc8inx 5564 21 6.97 6.97 CD cord-010092-uftc8inx 5564 22 % % NN cord-010092-uftc8inx 5564 23 ( ( -LRB- cord-010092-uftc8inx 5564 24 1063 1063 CD cord-010092-uftc8inx 5564 25 ) ) -RRB- cord-010092-uftc8inx 5564 26 for for IN cord-010092-uftc8inx 5564 27 female female JJ cord-010092-uftc8inx 5564 28 donors donor NNS cord-010092-uftc8inx 5564 29 When when WRB cord-010092-uftc8inx 5564 30 the the DT cord-010092-uftc8inx 5564 31 donor donor NN cord-010092-uftc8inx 5564 32 adverse adverse JJ cord-010092-uftc8inx 5564 33 events event NNS cord-010092-uftc8inx 5564 34 stratified stratify VBN cord-010092-uftc8inx 5564 35 age age NN cord-010092-uftc8inx 5564 36 - - HYPH cord-010092-uftc8inx 5564 37 wise wise RB cord-010092-uftc8inx 5564 38 , , , cord-010092-uftc8inx 5564 39 the the DT cord-010092-uftc8inx 5564 40 highest high JJS cord-010092-uftc8inx 5564 41 incidence incidence NN cord-010092-uftc8inx 5564 42 reported report VBN cord-010092-uftc8inx 5564 43 in in IN cord-010092-uftc8inx 5564 44 age age NN cord-010092-uftc8inx 5564 45 group group NN cord-010092-uftc8inx 5564 46 18 18 CD cord-010092-uftc8inx 5564 47 - - SYM cord-010092-uftc8inx 5564 48 24 24 CD cord-010092-uftc8inx 5564 49 years year NNS cord-010092-uftc8inx 5564 50 ( ( -LRB- cord-010092-uftc8inx 5564 51 male male JJ cord-010092-uftc8inx 5564 52 5.45 5.45 CD cord-010092-uftc8inx 5564 53 % % NN cord-010092-uftc8inx 5564 54 and and CC cord-010092-uftc8inx 5564 55 female female JJ cord-010092-uftc8inx 5564 56 13 13 CD cord-010092-uftc8inx 5564 57 % % NN cord-010092-uftc8inx 5564 58 ) ) -RRB- cord-010092-uftc8inx 5564 59 . . . cord-010092-uftc8inx 5565 1 Among among IN cord-010092-uftc8inx 5565 2 age age NN cord-010092-uftc8inx 5565 3 group group NN cord-010092-uftc8inx 5565 4 25 25 CD cord-010092-uftc8inx 5565 5 - - SYM cord-010092-uftc8inx 5565 6 40 40 CD cord-010092-uftc8inx 5565 7 years year NNS cord-010092-uftc8inx 5565 8 , , , cord-010092-uftc8inx 5565 9 ( ( -LRB- cord-010092-uftc8inx 5565 10 male male JJ cord-010092-uftc8inx 5565 11 2.4 2.4 CD cord-010092-uftc8inx 5565 12 % % NN cord-010092-uftc8inx 5565 13 and and CC cord-010092-uftc8inx 5565 14 female female JJ cord-010092-uftc8inx 5565 15 4.02 4.02 CD cord-010092-uftc8inx 5565 16 % % NN cord-010092-uftc8inx 5565 17 ) ) -RRB- cord-010092-uftc8inx 5565 18 , , , cord-010092-uftc8inx 5565 19 whereas whereas IN cord-010092-uftc8inx 5565 20 in in IN cord-010092-uftc8inx 5565 21 age age NN cord-010092-uftc8inx 5565 22 group group NN cord-010092-uftc8inx 5565 23 41 41 CD cord-010092-uftc8inx 5565 24 - - SYM cord-010092-uftc8inx 5565 25 65 65 CD cord-010092-uftc8inx 5565 26 years year NNS cord-010092-uftc8inx 5565 27 , , , cord-010092-uftc8inx 5565 28 ( ( -LRB- cord-010092-uftc8inx 5565 29 male male JJ cord-010092-uftc8inx 5565 30 1.52 1.52 CD cord-010092-uftc8inx 5565 31 % % NN cord-010092-uftc8inx 5565 32 and and CC cord-010092-uftc8inx 5565 33 female female JJ cord-010092-uftc8inx 5565 34 2.11 2.11 CD cord-010092-uftc8inx 5565 35 % % NN cord-010092-uftc8inx 5565 36 ) ) -RRB- cord-010092-uftc8inx 5565 37 Data data NN cord-010092-uftc8inx 5565 38 analysis analysis NN cord-010092-uftc8inx 5565 39 of of IN cord-010092-uftc8inx 5565 40 total total JJ cord-010092-uftc8inx 5565 41 6226 6226 CD cord-010092-uftc8inx 5565 42 reported report VBD cord-010092-uftc8inx 5565 43 and and CC cord-010092-uftc8inx 5565 44 registered registered JJ cord-010092-uftc8inx 5565 45 donor donor NN cord-010092-uftc8inx 5565 46 adverse adverse JJ cord-010092-uftc8inx 5565 47 events event NNS cord-010092-uftc8inx 5565 48 , , , cord-010092-uftc8inx 5565 49 are be VBP cord-010092-uftc8inx 5565 50 categorized categorize VBN cord-010092-uftc8inx 5565 51 as as IN cord-010092-uftc8inx 5565 52 Hyperventilation hyperventilation NN cord-010092-uftc8inx 5565 53 ( ( -LRB- cord-010092-uftc8inx 5565 54 864 864 CD cord-010092-uftc8inx 5565 55 ) ) -RRB- cord-010092-uftc8inx 5565 56 , , , cord-010092-uftc8inx 5565 57 Sweating sweating NN cord-010092-uftc8inx 5565 58 ( ( -LRB- cord-010092-uftc8inx 5565 59 1458 1458 CD cord-010092-uftc8inx 5565 60 ) ) -RRB- cord-010092-uftc8inx 5565 61 , , , cord-010092-uftc8inx 5565 62 Dizziness dizziness NN cord-010092-uftc8inx 5565 63 ( ( -LRB- cord-010092-uftc8inx 5565 64 pre pre JJ cord-010092-uftc8inx 5565 65 - - JJ cord-010092-uftc8inx 5565 66 syncopal syncopal JJ cord-010092-uftc8inx 5565 67 3160 3160 CD cord-010092-uftc8inx 5565 68 ) ) -RRB- cord-010092-uftc8inx 5565 69 , , , cord-010092-uftc8inx 5565 70 Loss loss NN cord-010092-uftc8inx 5565 71 of of IN cord-010092-uftc8inx 5565 72 consciousness consciousness NN cord-010092-uftc8inx 5565 73 ( ( -LRB- cord-010092-uftc8inx 5565 74 416 416 CD cord-010092-uftc8inx 5565 75 ) ) -RRB- cord-010092-uftc8inx 5565 76 , , , cord-010092-uftc8inx 5565 77 Vomiting vomiting NN cord-010092-uftc8inx 5565 78 ( ( -LRB- cord-010092-uftc8inx 5565 79 108 108 CD cord-010092-uftc8inx 5565 80 ) ) -RRB- cord-010092-uftc8inx 5565 81 , , , cord-010092-uftc8inx 5565 82 Convulsions convulsion NNS cord-010092-uftc8inx 5565 83 ( ( -LRB- cord-010092-uftc8inx 5565 84 220 220 CD cord-010092-uftc8inx 5565 85 ) ) -RRB- cord-010092-uftc8inx 5565 86 , , , cord-010092-uftc8inx 5565 87 Hematomas Hematomas NNP cord-010092-uftc8inx 5565 88 with with IN cord-010092-uftc8inx 5565 89 Re re NN cord-010092-uftc8inx 5565 90 - - NN cord-010092-uftc8inx 5565 91 bleed bleed JJ cord-010092-uftc8inx 5565 92 ( ( -LRB- cord-010092-uftc8inx 5565 93 255 255 CD cord-010092-uftc8inx 5565 94 ) ) -RRB- cord-010092-uftc8inx 5565 95 , , , cord-010092-uftc8inx 5565 96 Nerve nerve NN cord-010092-uftc8inx 5565 97 irritation irritation NN cord-010092-uftc8inx 5565 98 ( ( -LRB- cord-010092-uftc8inx 5565 99 8) 8) NN cord-010092-uftc8inx 5565 100 and and CC cord-010092-uftc8inx 5566 1 Off off IN cord-010092-uftc8inx 5566 2 - - HYPH cord-010092-uftc8inx 5566 3 site site NN cord-010092-uftc8inx 5566 4 reactions reaction NNS cord-010092-uftc8inx 5566 5 ( ( -LRB- cord-010092-uftc8inx 5566 6 333 333 CD cord-010092-uftc8inx 5566 7 ) ) -RRB- cord-010092-uftc8inx 5566 8 . . . cord-010092-uftc8inx 5567 1 Many many JJ cord-010092-uftc8inx 5567 2 donors donor NNS cord-010092-uftc8inx 5567 3 showed show VBD cord-010092-uftc8inx 5567 4 multiple multiple JJ cord-010092-uftc8inx 5567 5 forms form NNS cord-010092-uftc8inx 5567 6 of of IN cord-010092-uftc8inx 5567 7 reactions reaction NNS cord-010092-uftc8inx 5567 8 . . . cord-010092-uftc8inx 5568 1 Summary Summary NNP cord-010092-uftc8inx 5568 2 / / SYM cord-010092-uftc8inx 5568 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 5568 4 : : : cord-010092-uftc8inx 5569 1 Evaluation evaluation NN cord-010092-uftc8inx 5569 2 of of IN cord-010092-uftc8inx 5569 3 donor donor NN cord-010092-uftc8inx 5569 4 side side NN cord-010092-uftc8inx 5569 5 effects effect NNS cord-010092-uftc8inx 5569 6 helps help VBZ cord-010092-uftc8inx 5569 7 to to TO cord-010092-uftc8inx 5569 8 improve improve VB cord-010092-uftc8inx 5569 9 donation donation NN cord-010092-uftc8inx 5569 10 process process NN cord-010092-uftc8inx 5569 11 and and CC cord-010092-uftc8inx 5569 12 donor donor NN cord-010092-uftc8inx 5569 13 compliance compliance NN cord-010092-uftc8inx 5569 14 . . . cord-010092-uftc8inx 5570 1 Most most RBS cord-010092-uftc8inx 5570 2 frequently frequently RB cord-010092-uftc8inx 5570 3 recorded record VBN cord-010092-uftc8inx 5570 4 reaction reaction NN cord-010092-uftc8inx 5570 5 remains remain VBZ cord-010092-uftc8inx 5570 6 dizziness dizziness NN cord-010092-uftc8inx 5570 7 ( ( -LRB- cord-010092-uftc8inx 5570 8 pre pre JJ cord-010092-uftc8inx 5570 9 - - JJ cord-010092-uftc8inx 5570 10 syncopal syncopal JJ cord-010092-uftc8inx 5570 11 ) ) -RRB- cord-010092-uftc8inx 5570 12 . . . cord-010092-uftc8inx 5571 1 Our -PRON- PRP$ cord-010092-uftc8inx 5571 2 donor donor NN cord-010092-uftc8inx 5571 3 vigilance vigilance NN cord-010092-uftc8inx 5571 4 data datum NNS cord-010092-uftc8inx 5571 5 show show NN cord-010092-uftc8inx 5571 6 reactions reaction NNS cord-010092-uftc8inx 5571 7 occurred occur VBD cord-010092-uftc8inx 5571 8 more more RBR cord-010092-uftc8inx 5571 9 frequently frequently RB cord-010092-uftc8inx 5571 10 in in IN cord-010092-uftc8inx 5571 11 younger young JJR cord-010092-uftc8inx 5571 12 age age NN cord-010092-uftc8inx 5571 13 , , , cord-010092-uftc8inx 5571 14 female female JJ cord-010092-uftc8inx 5571 15 and and CC cord-010092-uftc8inx 5571 16 first first JJ cord-010092-uftc8inx 5571 17 time time NN cord-010092-uftc8inx 5571 18 donors donor NNS cord-010092-uftc8inx 5571 19 . . . cord-010092-uftc8inx 5572 1 Repeat repeat VB cord-010092-uftc8inx 5572 2 donation donation NN cord-010092-uftc8inx 5572 3 and and CC cord-010092-uftc8inx 5572 4 age age NN cord-010092-uftc8inx 5572 5 are be VBP cord-010092-uftc8inx 5572 6 predictors predictor NNS cord-010092-uftc8inx 5572 7 for for IN cord-010092-uftc8inx 5572 8 low low JJ cord-010092-uftc8inx 5572 9 rates rate NNS cord-010092-uftc8inx 5572 10 of of IN cord-010092-uftc8inx 5572 11 adverse adverse JJ cord-010092-uftc8inx 5572 12 events event NNS cord-010092-uftc8inx 5572 13 . . . cord-010092-uftc8inx 5573 1 Participation participation NN cord-010092-uftc8inx 5573 2 in in IN cord-010092-uftc8inx 5573 3 DHV DHV NNP cord-010092-uftc8inx 5573 4 implies imply VBZ cord-010092-uftc8inx 5573 5 an an DT cord-010092-uftc8inx 5573 6 effort effort NN cord-010092-uftc8inx 5573 7 to to TO cord-010092-uftc8inx 5573 8 improve improve VB cord-010092-uftc8inx 5573 9 donor donor NN cord-010092-uftc8inx 5573 10 care care NN cord-010092-uftc8inx 5573 11 and and CC cord-010092-uftc8inx 5573 12 safety safety NN cord-010092-uftc8inx 5573 13 infrastructure infrastructure NN cord-010092-uftc8inx 5573 14 and and CC cord-010092-uftc8inx 5573 15 a a DT cord-010092-uftc8inx 5573 16 desire desire NN cord-010092-uftc8inx 5573 17 for for IN cord-010092-uftc8inx 5573 18 national national JJ cord-010092-uftc8inx 5573 19 and and CC cord-010092-uftc8inx 5573 20 international international JJ cord-010092-uftc8inx 5573 21 comparisons comparison NNS cord-010092-uftc8inx 5573 22 to to TO cord-010092-uftc8inx 5573 23 determine determine VB cord-010092-uftc8inx 5573 24 best good JJS cord-010092-uftc8inx 5573 25 practices practice NNS cord-010092-uftc8inx 5573 26 and and CC cord-010092-uftc8inx 5573 27 also also RB cord-010092-uftc8inx 5573 28 to to TO cord-010092-uftc8inx 5573 29 look look VB cord-010092-uftc8inx 5573 30 into into IN cord-010092-uftc8inx 5573 31 effectiveness effectiveness NN cord-010092-uftc8inx 5573 32 of of IN cord-010092-uftc8inx 5573 33 risk risk NN cord-010092-uftc8inx 5573 34 reduction reduction NN cord-010092-uftc8inx 5573 35 strategies strategy NNS cord-010092-uftc8inx 5573 36 and and CC cord-010092-uftc8inx 5573 37 follow follow VB cord-010092-uftc8inx 5573 38 - - HYPH cord-010092-uftc8inx 5573 39 up up RP cord-010092-uftc8inx 5573 40 trends trend NNS cord-010092-uftc8inx 5573 41 . . . cord-010092-uftc8inx 5574 1 Pre pre JJ cord-010092-uftc8inx 5574 2 - - JJ cord-010092-uftc8inx 5574 3 donation donation NN cord-010092-uftc8inx 5574 4 hydration hydration NN cord-010092-uftc8inx 5574 5 was be VBD cord-010092-uftc8inx 5574 6 implemented implement VBN cord-010092-uftc8inx 5574 7 as as IN cord-010092-uftc8inx 5574 8 an an DT cord-010092-uftc8inx 5574 9 interventional interventional JJ cord-010092-uftc8inx 5574 10 tool tool NN cord-010092-uftc8inx 5574 11 to to TO cord-010092-uftc8inx 5574 12 test test VB cord-010092-uftc8inx 5574 13 the the DT cord-010092-uftc8inx 5574 14 effects effect NNS cord-010092-uftc8inx 5574 15 of of IN cord-010092-uftc8inx 5574 16 hydration hydration NN cord-010092-uftc8inx 5574 17 on on IN cord-010092-uftc8inx 5574 18 pre pre JJ cord-010092-uftc8inx 5574 19 - - JJ cord-010092-uftc8inx 5574 20 syncopal syncopal JJ cord-010092-uftc8inx 5574 21 reactions reaction NNS cord-010092-uftc8inx 5574 22 to to IN cord-010092-uftc8inx 5574 23 blood blood NN cord-010092-uftc8inx 5574 24 donation donation NN cord-010092-uftc8inx 5574 25 , , , cord-010092-uftc8inx 5574 26 specifically specifically RB cord-010092-uftc8inx 5574 27 targeting target VBG cord-010092-uftc8inx 5574 28 those those DT cord-010092-uftc8inx 5574 29 at at IN cord-010092-uftc8inx 5574 30 highest high JJS cord-010092-uftc8inx 5574 31 risk risk NN cord-010092-uftc8inx 5574 32 such such JJ cord-010092-uftc8inx 5574 33 as as IN cord-010092-uftc8inx 5574 34 female female JJ cord-010092-uftc8inx 5574 35 , , , cord-010092-uftc8inx 5574 36 first first JJ cord-010092-uftc8inx 5574 37 - - HYPH cord-010092-uftc8inx 5574 38 time time NN cord-010092-uftc8inx 5574 39 , , , cord-010092-uftc8inx 5574 40 high high JJ cord-010092-uftc8inx 5574 41 school school NN cord-010092-uftc8inx 5574 42 donors donor NNS cord-010092-uftc8inx 5574 43 . . . cord-010092-uftc8inx 5575 1 The the DT cord-010092-uftc8inx 5575 2 results result NNS cord-010092-uftc8inx 5575 3 are be VBP cord-010092-uftc8inx 5575 4 awaited await VBN cord-010092-uftc8inx 5575 5 . . . cord-010092-uftc8inx 5576 1 Background background NN cord-010092-uftc8inx 5576 2 : : : cord-010092-uftc8inx 5577 1 Descriptions description NNS cord-010092-uftc8inx 5577 2 of of IN cord-010092-uftc8inx 5577 3 deferral deferral NN cord-010092-uftc8inx 5577 4 categories category NNS cord-010092-uftc8inx 5577 5 and and CC cord-010092-uftc8inx 5577 6 a a DT cord-010092-uftc8inx 5577 7 knowledge knowledge NN cord-010092-uftc8inx 5577 8 in in IN cord-010092-uftc8inx 5577 9 the the DT cord-010092-uftc8inx 5577 10 percentage percentage NN cord-010092-uftc8inx 5577 11 of of IN cord-010092-uftc8inx 5577 12 deferrals deferral NNS cord-010092-uftc8inx 5577 13 in in IN cord-010092-uftc8inx 5577 14 each each DT cord-010092-uftc8inx 5577 15 category category NN cord-010092-uftc8inx 5577 16 are be VBP cord-010092-uftc8inx 5577 17 of of IN cord-010092-uftc8inx 5577 18 value value NN cord-010092-uftc8inx 5577 19 in in IN cord-010092-uftc8inx 5577 20 formulating formulate VBG cord-010092-uftc8inx 5577 21 recruitment recruitment NN cord-010092-uftc8inx 5577 22 and and CC cord-010092-uftc8inx 5577 23 retention retention NN cord-010092-uftc8inx 5577 24 strategies strategy NNS cord-010092-uftc8inx 5577 25 . . . cord-010092-uftc8inx 5578 1 This this DT cord-010092-uftc8inx 5578 2 can can MD cord-010092-uftc8inx 5578 3 also also RB cord-010092-uftc8inx 5578 4 help help VB cord-010092-uftc8inx 5578 5 in in IN cord-010092-uftc8inx 5578 6 planning plan VBG cord-010092-uftc8inx 5578 7 more more RBR cord-010092-uftc8inx 5578 8 efficient efficient JJ cord-010092-uftc8inx 5578 9 recruitment recruitment NN cord-010092-uftc8inx 5578 10 strategies strategy NNS cord-010092-uftc8inx 5578 11 and and CC cord-010092-uftc8inx 5578 12 thereby thereby RB cord-010092-uftc8inx 5578 13 assist assist VB cord-010092-uftc8inx 5578 14 in in IN cord-010092-uftc8inx 5578 15 reducing reduce VBG cord-010092-uftc8inx 5578 16 the the DT cord-010092-uftc8inx 5578 17 shortage shortage NN cord-010092-uftc8inx 5578 18 in in IN cord-010092-uftc8inx 5578 19 blood blood NN cord-010092-uftc8inx 5578 20 supply supply NN cord-010092-uftc8inx 5578 21 . . . cord-010092-uftc8inx 5579 1 Aims aim VBZ cord-010092-uftc8inx 5579 2 : : : cord-010092-uftc8inx 5580 1 The the DT cord-010092-uftc8inx 5580 2 aim aim NN cord-010092-uftc8inx 5580 3 of of IN cord-010092-uftc8inx 5580 4 the the DT cord-010092-uftc8inx 5580 5 study study NN cord-010092-uftc8inx 5580 6 is be VBZ cord-010092-uftc8inx 5580 7 to to TO cord-010092-uftc8inx 5580 8 categorize categorize VB cord-010092-uftc8inx 5580 9 all all DT cord-010092-uftc8inx 5580 10 donors donor NNS cord-010092-uftc8inx 5580 11 who who WP cord-010092-uftc8inx 5580 12 were be VBD cord-010092-uftc8inx 5580 13 deferred defer VBN cord-010092-uftc8inx 5580 14 during during IN cord-010092-uftc8inx 5580 15 medical medical JJ cord-010092-uftc8inx 5580 16 checkup checkup NN cord-010092-uftc8inx 5580 17 and and CC cord-010092-uftc8inx 5580 18 find find VB cord-010092-uftc8inx 5580 19 out out RP cord-010092-uftc8inx 5580 20 the the DT cord-010092-uftc8inx 5580 21 donor donor NN cord-010092-uftc8inx 5580 22 deferral deferral NN cord-010092-uftc8inx 5580 23 rate rate NN cord-010092-uftc8inx 5580 24 in in IN cord-010092-uftc8inx 5580 25 Dubai Dubai NNP cord-010092-uftc8inx 5580 26 Blood Blood NNP cord-010092-uftc8inx 5580 27 Donation Donation NNP cord-010092-uftc8inx 5580 28 Center Center NNP cord-010092-uftc8inx 5580 29 from from IN cord-010092-uftc8inx 5580 30 January January NNP cord-010092-uftc8inx 5580 31 1 1 CD cord-010092-uftc8inx 5580 32 st st NNP cord-010092-uftc8inx 5580 33 2016 2016 CD cord-010092-uftc8inx 5580 34 to to IN cord-010092-uftc8inx 5580 35 December December NNP cord-010092-uftc8inx 5580 36 31 31 CD cord-010092-uftc8inx 5580 37 st st NNP cord-010092-uftc8inx 5580 38 2018 2018 CD cord-010092-uftc8inx 5580 39 and and CC cord-010092-uftc8inx 5580 40 also also RB cord-010092-uftc8inx 5580 41 to to TO cord-010092-uftc8inx 5580 42 find find VB cord-010092-uftc8inx 5580 43 out out RP cord-010092-uftc8inx 5580 44 whether whether IN cord-010092-uftc8inx 5580 45 there there EX cord-010092-uftc8inx 5580 46 is be VBZ cord-010092-uftc8inx 5580 47 any any DT cord-010092-uftc8inx 5580 48 yearly yearly JJ cord-010092-uftc8inx 5580 49 or or CC cord-010092-uftc8inx 5580 50 seasonal seasonal JJ cord-010092-uftc8inx 5580 51 trend trend NN cord-010092-uftc8inx 5580 52 in in IN cord-010092-uftc8inx 5580 53 any any DT cord-010092-uftc8inx 5580 54 of of IN cord-010092-uftc8inx 5580 55 the the DT cord-010092-uftc8inx 5580 56 categories category NNS cord-010092-uftc8inx 5580 57 of of IN cord-010092-uftc8inx 5580 58 deferral deferral NN cord-010092-uftc8inx 5580 59 criteria criterion NNS cord-010092-uftc8inx 5580 60 's 's POS cord-010092-uftc8inx 5580 61 which which WDT cord-010092-uftc8inx 5580 62 can can MD cord-010092-uftc8inx 5580 63 aid aid VB cord-010092-uftc8inx 5580 64 in in IN cord-010092-uftc8inx 5580 65 forecasting forecasting NN cord-010092-uftc8inx 5580 66 and and CC cord-010092-uftc8inx 5580 67 managing manage VBG cord-010092-uftc8inx 5580 68 donor donor NN cord-010092-uftc8inx 5580 69 pool pool NN cord-010092-uftc8inx 5580 70 . . . cord-010092-uftc8inx 5581 1 Methods method NNS cord-010092-uftc8inx 5581 2 : : : cord-010092-uftc8inx 5582 1 A a DT cord-010092-uftc8inx 5582 2 retrospective retrospective JJ cord-010092-uftc8inx 5582 3 study study NN cord-010092-uftc8inx 5582 4 of of IN cord-010092-uftc8inx 5582 5 donors donor NNS cord-010092-uftc8inx 5582 6 deferred defer VBN cord-010092-uftc8inx 5582 7 during during IN cord-010092-uftc8inx 5582 8 last last JJ cord-010092-uftc8inx 5582 9 three three CD cord-010092-uftc8inx 5582 10 years year NNS cord-010092-uftc8inx 5582 11 from from IN cord-010092-uftc8inx 5582 12 January January NNP cord-010092-uftc8inx 5582 13 1 1 CD cord-010092-uftc8inx 5582 14 st st NNP cord-010092-uftc8inx 5582 15 2016 2016 CD cord-010092-uftc8inx 5582 16 to to IN cord-010092-uftc8inx 5582 17 December December NNP cord-010092-uftc8inx 5582 18 31 31 CD cord-010092-uftc8inx 5582 19 st st NNP cord-010092-uftc8inx 5582 20 2018 2018 CD cord-010092-uftc8inx 5582 21 was be VBD cord-010092-uftc8inx 5582 22 done do VBN cord-010092-uftc8inx 5582 23 in in IN cord-010092-uftc8inx 5582 24 Dubai Dubai NNP cord-010092-uftc8inx 5582 25 Blood Blood NNP cord-010092-uftc8inx 5582 26 Donation Donation NNP cord-010092-uftc8inx 5582 27 Centre Centre NNP cord-010092-uftc8inx 5582 28 . . . cord-010092-uftc8inx 5583 1 The the DT cord-010092-uftc8inx 5583 2 donors donor NNS cord-010092-uftc8inx 5583 3 deferred defer VBD cord-010092-uftc8inx 5583 4 during during IN cord-010092-uftc8inx 5583 5 pre pre JJ cord-010092-uftc8inx 5583 6 - - JJ cord-010092-uftc8inx 5583 7 donation donation JJ cord-010092-uftc8inx 5583 8 medical medical JJ cord-010092-uftc8inx 5583 9 check check NN cord-010092-uftc8inx 5583 10 - - HYPH cord-010092-uftc8inx 5583 11 up up NN cord-010092-uftc8inx 5583 12 were be VBD cord-010092-uftc8inx 5583 13 categorized categorize VBN cord-010092-uftc8inx 5583 14 into into IN cord-010092-uftc8inx 5583 15 8 8 CD cord-010092-uftc8inx 5583 16 categories category NNS cord-010092-uftc8inx 5583 17 including include VBG cord-010092-uftc8inx 5583 18 low low JJ cord-010092-uftc8inx 5583 19 Hemoglobin hemoglobin NN cord-010092-uftc8inx 5583 20 , , , cord-010092-uftc8inx 5583 21 High high JJ cord-010092-uftc8inx 5583 22 and and CC cord-010092-uftc8inx 5583 23 low low JJ cord-010092-uftc8inx 5583 24 BP BP NNP cord-010092-uftc8inx 5583 25 , , , cord-010092-uftc8inx 5583 26 intake intake NN cord-010092-uftc8inx 5583 27 of of IN cord-010092-uftc8inx 5583 28 antibiotic antibiotic NN cord-010092-uftc8inx 5583 29 , , , cord-010092-uftc8inx 5583 30 fever fever NN cord-010092-uftc8inx 5583 31 and and CC cord-010092-uftc8inx 5583 32 flu flu NN cord-010092-uftc8inx 5583 33 , , , cord-010092-uftc8inx 5583 34 taking take VBG cord-010092-uftc8inx 5583 35 other other JJ cord-010092-uftc8inx 5583 36 medications medication NNS cord-010092-uftc8inx 5583 37 , , , cord-010092-uftc8inx 5583 38 travel travel NN cord-010092-uftc8inx 5583 39 history history NN cord-010092-uftc8inx 5583 40 etc etc FW cord-010092-uftc8inx 5583 41 . . . cord-010092-uftc8inx 5584 1 The the DT cord-010092-uftc8inx 5584 2 deferrals deferral NNS cord-010092-uftc8inx 5584 3 were be VBD cord-010092-uftc8inx 5584 4 analyzed analyze VBN cord-010092-uftc8inx 5584 5 monthly monthly JJ cord-010092-uftc8inx 5584 6 and and CC cord-010092-uftc8inx 5584 7 yearly yearly JJ cord-010092-uftc8inx 5584 8 and and CC cord-010092-uftc8inx 5584 9 then then RB cord-010092-uftc8inx 5584 10 were be VBD cord-010092-uftc8inx 5584 11 compiled compile VBN cord-010092-uftc8inx 5584 12 to to TO cord-010092-uftc8inx 5584 13 find find VB cord-010092-uftc8inx 5584 14 any any DT cord-010092-uftc8inx 5584 15 yearly yearly JJ cord-010092-uftc8inx 5584 16 trend trend NN cord-010092-uftc8inx 5584 17 or or CC cord-010092-uftc8inx 5584 18 seasonal seasonal JJ cord-010092-uftc8inx 5584 19 trend trend NN cord-010092-uftc8inx 5584 20 in in IN cord-010092-uftc8inx 5584 21 the the DT cord-010092-uftc8inx 5584 22 donor donor NN cord-010092-uftc8inx 5584 23 deferral deferral NN cord-010092-uftc8inx 5584 24 rate rate NN cord-010092-uftc8inx 5584 25 in in IN cord-010092-uftc8inx 5584 26 any any DT cord-010092-uftc8inx 5584 27 of of IN cord-010092-uftc8inx 5584 28 the the DT cord-010092-uftc8inx 5584 29 categories category NNS cord-010092-uftc8inx 5584 30 . . . cord-010092-uftc8inx 5585 1 The the DT cord-010092-uftc8inx 5585 2 data datum NNS cord-010092-uftc8inx 5585 3 were be VBD cord-010092-uftc8inx 5585 4 analyzed analyze VBN cord-010092-uftc8inx 5585 5 using use VBG cord-010092-uftc8inx 5585 6 the the DT cord-010092-uftc8inx 5585 7 SPSS SPSS NNP cord-010092-uftc8inx 5585 8 software software NN cord-010092-uftc8inx 5585 9 and and CC cord-010092-uftc8inx 5585 10 a a DT cord-010092-uftc8inx 5585 11 P p NN cord-010092-uftc8inx 5585 12 value value NN cord-010092-uftc8inx 5585 13 of of IN cord-010092-uftc8inx 5585 14 < < NNP cord-010092-uftc8inx 5585 15 0.05 0.05 CD cord-010092-uftc8inx 5585 16 was be VBD cord-010092-uftc8inx 5585 17 considered consider VBN cord-010092-uftc8inx 5585 18 significant significant JJ cord-010092-uftc8inx 5585 19 . . . cord-010092-uftc8inx 5586 1 The the DT cord-010092-uftc8inx 5586 2 assessment assessment NN cord-010092-uftc8inx 5586 3 of of IN cord-010092-uftc8inx 5586 4 donor donor NN cord-010092-uftc8inx 5586 5 suitability suitability NN cord-010092-uftc8inx 5586 6 is be VBZ cord-010092-uftc8inx 5586 7 in in IN cord-010092-uftc8inx 5586 8 accordance accordance NN cord-010092-uftc8inx 5586 9 with with IN cord-010092-uftc8inx 5586 10 AABB AABB NNP cord-010092-uftc8inx 5586 11 standards standard NNS cord-010092-uftc8inx 5586 12 and and CC cord-010092-uftc8inx 5586 13 is be VBZ cord-010092-uftc8inx 5586 14 consistently consistently RB cord-010092-uftc8inx 5586 15 applied apply VBN cord-010092-uftc8inx 5586 16 in in IN cord-010092-uftc8inx 5586 17 every every DT cord-010092-uftc8inx 5586 18 blood blood NN cord-010092-uftc8inx 5586 19 donation donation NN cord-010092-uftc8inx 5586 20 setting set VBG cord-010092-uftc8inx 5586 21 on on IN cord-010092-uftc8inx 5586 22 each each DT cord-010092-uftc8inx 5586 23 occasion occasion NN cord-010092-uftc8inx 5586 24 of of IN cord-010092-uftc8inx 5586 25 donation donation NN cord-010092-uftc8inx 5586 26 to to IN cord-010092-uftc8inx 5586 27 all all DT cord-010092-uftc8inx 5586 28 blood blood NN cord-010092-uftc8inx 5586 29 donors donor NNS cord-010092-uftc8inx 5586 30 . . . cord-010092-uftc8inx 5587 1 Results result NNS cord-010092-uftc8inx 5587 2 : : : cord-010092-uftc8inx 5588 1 During during IN cord-010092-uftc8inx 5588 2 this this DT cord-010092-uftc8inx 5588 3 study study NN cord-010092-uftc8inx 5588 4 , , , cord-010092-uftc8inx 5588 5 193,228 193,228 CD cord-010092-uftc8inx 5588 6 donors donor NNS cord-010092-uftc8inx 5588 7 were be VBD cord-010092-uftc8inx 5588 8 registered register VBN cord-010092-uftc8inx 5588 9 from from IN cord-010092-uftc8inx 5588 10 January January NNP cord-010092-uftc8inx 5588 11 1 1 CD cord-010092-uftc8inx 5588 12 st st NNP cord-010092-uftc8inx 5588 13 2016 2016 CD cord-010092-uftc8inx 5588 14 to to IN cord-010092-uftc8inx 5588 15 December December NNP cord-010092-uftc8inx 5588 16 31 31 CD cord-010092-uftc8inx 5588 17 st st NNP cord-010092-uftc8inx 5588 18 2018 2018 CD cord-010092-uftc8inx 5588 19 and and CC cord-010092-uftc8inx 5588 20 41,037 41,037 CD cord-010092-uftc8inx 5588 21 ( ( -LRB- cord-010092-uftc8inx 5588 22 21.24 21.24 CD cord-010092-uftc8inx 5588 23 % % NN cord-010092-uftc8inx 5588 24 ) ) -RRB- cord-010092-uftc8inx 5588 25 donors donor NNS cord-010092-uftc8inx 5588 26 were be VBD cord-010092-uftc8inx 5588 27 deferred defer VBN cord-010092-uftc8inx 5588 28 . . . cord-010092-uftc8inx 5589 1 The the DT cord-010092-uftc8inx 5589 2 common common JJ cord-010092-uftc8inx 5589 3 reasons reason NNS cord-010092-uftc8inx 5589 4 of of IN cord-010092-uftc8inx 5589 5 deferral deferral NN cord-010092-uftc8inx 5589 6 were be VBD cord-010092-uftc8inx 5589 7 low low JJ cord-010092-uftc8inx 5589 8 Hb Hb NNP cord-010092-uftc8inx 5589 9 , , , cord-010092-uftc8inx 5589 10 High High NNP cord-010092-uftc8inx 5589 11 BP BP NNP cord-010092-uftc8inx 5589 12 , , , cord-010092-uftc8inx 5589 13 Travel Travel NNP cord-010092-uftc8inx 5589 14 history history NN cord-010092-uftc8inx 5589 15 , , , cord-010092-uftc8inx 5589 16 intake intake NN cord-010092-uftc8inx 5589 17 of of IN cord-010092-uftc8inx 5589 18 antibiotics antibiotic NNS cord-010092-uftc8inx 5589 19 and and CC cord-010092-uftc8inx 5589 20 cough cough NN cord-010092-uftc8inx 5589 21 / / SYM cord-010092-uftc8inx 5589 22 flu flu NN cord-010092-uftc8inx 5589 23 symptoms symptom NNS cord-010092-uftc8inx 5589 24 . . . cord-010092-uftc8inx 5590 1 There there EX cord-010092-uftc8inx 5590 2 was be VBD cord-010092-uftc8inx 5590 3 a a DT cord-010092-uftc8inx 5590 4 significant significant JJ cord-010092-uftc8inx 5590 5 decrease decrease NN cord-010092-uftc8inx 5590 6 in in IN cord-010092-uftc8inx 5590 7 deferral deferral NN cord-010092-uftc8inx 5590 8 rate rate NN cord-010092-uftc8inx 5590 9 from from IN cord-010092-uftc8inx 5590 10 24.07 24.07 CD cord-010092-uftc8inx 5590 11 % % NN cord-010092-uftc8inx 5590 12 ( ( -LRB- cord-010092-uftc8inx 5590 13 15302/63563 15302/63563 CD cord-010092-uftc8inx 5590 14 ) ) -RRB- cord-010092-uftc8inx 5590 15 in in IN cord-010092-uftc8inx 5590 16 2016 2016 CD cord-010092-uftc8inx 5590 17 to to IN cord-010092-uftc8inx 5590 18 20.79 20.79 CD cord-010092-uftc8inx 5590 19 % % NN cord-010092-uftc8inx 5590 20 ( ( -LRB- cord-010092-uftc8inx 5590 21 13180/63394)in 13180/63394)in CD cord-010092-uftc8inx 5590 22 2017 2017 CD cord-010092-uftc8inx 5590 23 and and CC cord-010092-uftc8inx 5590 24 further further RB cord-010092-uftc8inx 5590 25 to to IN cord-010092-uftc8inx 5590 26 18.74 18.74 CD cord-010092-uftc8inx 5590 27 % % NN cord-010092-uftc8inx 5590 28 ( ( -LRB- cord-010092-uftc8inx 5590 29 12419/66271 12419/66271 CD cord-010092-uftc8inx 5590 30 ) ) -RRB- cord-010092-uftc8inx 5590 31 in in IN cord-010092-uftc8inx 5590 32 2018 2018 CD cord-010092-uftc8inx 5590 33 ( ( -LRB- cord-010092-uftc8inx 5590 34 P p NN cord-010092-uftc8inx 5590 35 < < XX cord-010092-uftc8inx 5590 36 0.05 0.05 CD cord-010092-uftc8inx 5590 37 ) ) -RRB- cord-010092-uftc8inx 5590 38 . . . cord-010092-uftc8inx 5591 1 The the DT cord-010092-uftc8inx 5591 2 specific specific JJ cord-010092-uftc8inx 5591 3 deferral deferral NN cord-010092-uftc8inx 5591 4 rate rate NN cord-010092-uftc8inx 5591 5 due due IN cord-010092-uftc8inx 5591 6 to to IN cord-010092-uftc8inx 5591 7 low low JJ cord-010092-uftc8inx 5591 8 Hb Hb NNP cord-010092-uftc8inx 5591 9 also also RB cord-010092-uftc8inx 5591 10 significantly significantly RB cord-010092-uftc8inx 5591 11 ( ( -LRB- cord-010092-uftc8inx 5591 12 P p NN cord-010092-uftc8inx 5591 13 decreased decrease VBD cord-010092-uftc8inx 5591 14 during during IN cord-010092-uftc8inx 5591 15 these these DT cord-010092-uftc8inx 5591 16 three three CD cord-010092-uftc8inx 5591 17 years year NNS cord-010092-uftc8inx 5591 18 ( ( -LRB- cord-010092-uftc8inx 5591 19 86/1000 86/1000 CD cord-010092-uftc8inx 5591 20 in in IN cord-010092-uftc8inx 5591 21 2016 2016 CD cord-010092-uftc8inx 5591 22 , , , cord-010092-uftc8inx 5591 23 68/1000 68/1000 CD cord-010092-uftc8inx 5591 24 in in IN cord-010092-uftc8inx 5591 25 2017 2017 CD cord-010092-uftc8inx 5591 26 , , , cord-010092-uftc8inx 5591 27 58/1000 58/1000 CD cord-010092-uftc8inx 5591 28 in in IN cord-010092-uftc8inx 5591 29 2018 2018 CD cord-010092-uftc8inx 5591 30 ) ) -RRB- cord-010092-uftc8inx 5591 31 , , , cord-010092-uftc8inx 5591 32 though though IN cord-010092-uftc8inx 5591 33 no no DT cord-010092-uftc8inx 5591 34 change change NN cord-010092-uftc8inx 5591 35 was be VBD cord-010092-uftc8inx 5591 36 seen see VBN cord-010092-uftc8inx 5591 37 in in IN cord-010092-uftc8inx 5591 38 the the DT cord-010092-uftc8inx 5591 39 deferral deferral NN cord-010092-uftc8inx 5591 40 due due IN cord-010092-uftc8inx 5591 41 to to IN cord-010092-uftc8inx 5591 42 other other JJ cord-010092-uftc8inx 5591 43 reasons reason NNS cord-010092-uftc8inx 5591 44 . . . cord-010092-uftc8inx 5592 1 The the DT cord-010092-uftc8inx 5592 2 reduction reduction NN cord-010092-uftc8inx 5592 3 in in IN cord-010092-uftc8inx 5592 4 the the DT cord-010092-uftc8inx 5592 5 rate rate NN cord-010092-uftc8inx 5592 6 of of IN cord-010092-uftc8inx 5592 7 deferral deferral NN cord-010092-uftc8inx 5592 8 due due IN cord-010092-uftc8inx 5592 9 to to IN cord-010092-uftc8inx 5592 10 low low JJ cord-010092-uftc8inx 5592 11 hemoglobin hemoglobin NN cord-010092-uftc8inx 5592 12 may may MD cord-010092-uftc8inx 5592 13 - - HYPH cord-010092-uftc8inx 5592 14 be be VB cord-010092-uftc8inx 5592 15 linked link VBN cord-010092-uftc8inx 5592 16 to to IN cord-010092-uftc8inx 5592 17 the the DT cord-010092-uftc8inx 5592 18 change change NN cord-010092-uftc8inx 5592 19 in in IN cord-010092-uftc8inx 5592 20 the the DT cord-010092-uftc8inx 5592 21 staff staff NN cord-010092-uftc8inx 5592 22 performing perform VBG cord-010092-uftc8inx 5592 23 the the DT cord-010092-uftc8inx 5592 24 hemoglobin hemoglobin NN cord-010092-uftc8inx 5592 25 testing testing NN cord-010092-uftc8inx 5592 26 in in IN cord-010092-uftc8inx 5592 27 DBDC DBDC NNP cord-010092-uftc8inx 5592 28 ( ( -LRB- cord-010092-uftc8inx 5592 29 nurses nurse NNS cord-010092-uftc8inx 5592 30 instead instead RB cord-010092-uftc8inx 5592 31 of of IN cord-010092-uftc8inx 5592 32 phlebotomist phlebotomist NN cord-010092-uftc8inx 5592 33 were be VBD cord-010092-uftc8inx 5592 34 assigned assign VBN cord-010092-uftc8inx 5592 35 to to TO cord-010092-uftc8inx 5592 36 perform perform VB cord-010092-uftc8inx 5592 37 Hb Hb NNP cord-010092-uftc8inx 5592 38 estimation estimation NN cord-010092-uftc8inx 5592 39 of of IN cord-010092-uftc8inx 5592 40 donors donor NNS cord-010092-uftc8inx 5592 41 ) ) -RRB- cord-010092-uftc8inx 5592 42 . . . cord-010092-uftc8inx 5593 1 There there EX cord-010092-uftc8inx 5593 2 was be VBD cord-010092-uftc8inx 5593 3 a a DT cord-010092-uftc8inx 5593 4 seasonal seasonal JJ cord-010092-uftc8inx 5593 5 variation variation NN cord-010092-uftc8inx 5593 6 in in IN cord-010092-uftc8inx 5593 7 the the DT cord-010092-uftc8inx 5593 8 deferral deferral NN cord-010092-uftc8inx 5593 9 rate rate NN cord-010092-uftc8inx 5593 10 in in IN cord-010092-uftc8inx 5593 11 all all PDT cord-010092-uftc8inx 5593 12 the the DT cord-010092-uftc8inx 5593 13 three three CD cord-010092-uftc8inx 5593 14 years year NNS cord-010092-uftc8inx 5593 15 - - , cord-010092-uftc8inx 5593 16 lowest low JJS cord-010092-uftc8inx 5593 17 in in IN cord-010092-uftc8inx 5593 18 June June NNP cord-010092-uftc8inx 5593 19 ( ( -LRB- cord-010092-uftc8inx 5593 20 6/1000 6/1000 CD cord-010092-uftc8inx 5593 21 ) ) -RRB- cord-010092-uftc8inx 5593 22 and and CC cord-010092-uftc8inx 5593 23 then then RB cord-010092-uftc8inx 5593 24 increasing increase VBG cord-010092-uftc8inx 5593 25 with with IN cord-010092-uftc8inx 5593 26 a a DT cord-010092-uftc8inx 5593 27 peak peak NN cord-010092-uftc8inx 5593 28 in in IN cord-010092-uftc8inx 5593 29 October October NNP cord-010092-uftc8inx 5593 30 ( ( -LRB- cord-010092-uftc8inx 5593 31 19/1000 19/1000 CD cord-010092-uftc8inx 5593 32 ) ) -RRB- cord-010092-uftc8inx 5593 33 and and CC cord-010092-uftc8inx 5593 34 plateauing plateaue VBG cord-010092-uftc8inx 5593 35 till till IN cord-010092-uftc8inx 5593 36 January January NNP cord-010092-uftc8inx 5593 37 . . . cord-010092-uftc8inx 5594 1 This this DT cord-010092-uftc8inx 5594 2 pattern pattern NN cord-010092-uftc8inx 5594 3 of of IN cord-010092-uftc8inx 5594 4 deferral deferral NN cord-010092-uftc8inx 5594 5 corroborated corroborate VBN cord-010092-uftc8inx 5594 6 with with IN cord-010092-uftc8inx 5594 7 the the DT cord-010092-uftc8inx 5594 8 rate rate NN cord-010092-uftc8inx 5594 9 of of IN cord-010092-uftc8inx 5594 10 deferral deferral NN cord-010092-uftc8inx 5594 11 due due IN cord-010092-uftc8inx 5594 12 to to IN cord-010092-uftc8inx 5594 13 flu flu NN cord-010092-uftc8inx 5594 14 / / SYM cord-010092-uftc8inx 5594 15 fever fever NN cord-010092-uftc8inx 5594 16 and and CC cord-010092-uftc8inx 5594 17 cough cough NN cord-010092-uftc8inx 5594 18 and and CC cord-010092-uftc8inx 5594 19 antibiotics antibiotic NNS cord-010092-uftc8inx 5594 20 with with IN cord-010092-uftc8inx 5594 21 an an DT cord-010092-uftc8inx 5594 22 average average NN cord-010092-uftc8inx 5594 23 of of IN cord-010092-uftc8inx 5594 24 4/1000 4/1000 CD cord-010092-uftc8inx 5594 25 in in IN cord-010092-uftc8inx 5594 26 June June NNP cord-010092-uftc8inx 5594 27 and and CC cord-010092-uftc8inx 5594 28 increasing increase VBG cord-010092-uftc8inx 5594 29 to to IN cord-010092-uftc8inx 5594 30 10/1000 10/1000 CD cord-010092-uftc8inx 5594 31 in in IN cord-010092-uftc8inx 5594 32 October October NNP cord-010092-uftc8inx 5594 33 ( ( -LRB- cord-010092-uftc8inx 5594 34 P p NN cord-010092-uftc8inx 5594 35 < < XX cord-010092-uftc8inx 5594 36 0.05 0.05 CD cord-010092-uftc8inx 5594 37 ) ) -RRB- cord-010092-uftc8inx 5594 38 . . . cord-010092-uftc8inx 5595 1 Summary Summary NNP cord-010092-uftc8inx 5595 2 / / SYM cord-010092-uftc8inx 5595 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 5595 4 : : : cord-010092-uftc8inx 5596 1 Staff staff NN cord-010092-uftc8inx 5596 2 competency competency NN cord-010092-uftc8inx 5596 3 is be VBZ cord-010092-uftc8inx 5596 4 pertinent pertinent JJ cord-010092-uftc8inx 5596 5 in in IN cord-010092-uftc8inx 5596 6 accurately accurately RB cord-010092-uftc8inx 5596 7 deferring defer VBG cord-010092-uftc8inx 5596 8 donors donor NNS cord-010092-uftc8inx 5596 9 . . . cord-010092-uftc8inx 5597 1 There there EX cord-010092-uftc8inx 5597 2 is be VBZ cord-010092-uftc8inx 5597 3 also also RB cord-010092-uftc8inx 5597 4 a a DT cord-010092-uftc8inx 5597 5 significant significant JJ cord-010092-uftc8inx 5597 6 seasonal seasonal JJ cord-010092-uftc8inx 5597 7 pattern pattern NN cord-010092-uftc8inx 5597 8 in in IN cord-010092-uftc8inx 5597 9 flu flu NN cord-010092-uftc8inx 5597 10 / / SYM cord-010092-uftc8inx 5597 11 fever fever NN cord-010092-uftc8inx 5597 12 and and CC cord-010092-uftc8inx 5597 13 intake intake NN cord-010092-uftc8inx 5597 14 of of IN cord-010092-uftc8inx 5597 15 antibiotics antibiotic NNS cord-010092-uftc8inx 5597 16 deferral deferral NN cord-010092-uftc8inx 5597 17 rate rate NN cord-010092-uftc8inx 5597 18 that that WDT cord-010092-uftc8inx 5597 19 is be VBZ cord-010092-uftc8inx 5597 20 reflected reflect VBN cord-010092-uftc8inx 5597 21 in in IN cord-010092-uftc8inx 5597 22 the the DT cord-010092-uftc8inx 5597 23 total total JJ cord-010092-uftc8inx 5597 24 donor donor NN cord-010092-uftc8inx 5597 25 deferral deferral NN cord-010092-uftc8inx 5597 26 pattern pattern NN cord-010092-uftc8inx 5597 27 . . . cord-010092-uftc8inx 5598 1 Seasonal seasonal JJ cord-010092-uftc8inx 5598 2 variation variation NN cord-010092-uftc8inx 5598 3 of of IN cord-010092-uftc8inx 5598 4 specific specific JJ cord-010092-uftc8inx 5598 5 category category NN cord-010092-uftc8inx 5598 6 of of IN cord-010092-uftc8inx 5598 7 donor donor NN cord-010092-uftc8inx 5598 8 deferral deferral NN cord-010092-uftc8inx 5598 9 should should MD cord-010092-uftc8inx 5598 10 be be VB cord-010092-uftc8inx 5598 11 taken take VBN cord-010092-uftc8inx 5598 12 into into IN cord-010092-uftc8inx 5598 13 account account NN cord-010092-uftc8inx 5598 14 for for IN cord-010092-uftc8inx 5598 15 donor donor NN cord-010092-uftc8inx 5598 16 recruitment recruitment NN cord-010092-uftc8inx 5598 17 and and CC cord-010092-uftc8inx 5598 18 retention retention NN cord-010092-uftc8inx 5598 19 efforts effort NNS cord-010092-uftc8inx 5598 20 . . . cord-010092-uftc8inx 5599 1 Background background NN cord-010092-uftc8inx 5599 2 : : : cord-010092-uftc8inx 5600 1 West West NNP cord-010092-uftc8inx 5600 2 Nile Nile NNP cord-010092-uftc8inx 5600 3 Virus Virus NNP cord-010092-uftc8inx 5600 4 ( ( -LRB- cord-010092-uftc8inx 5600 5 WNV WNV NNP cord-010092-uftc8inx 5600 6 ) ) -RRB- cord-010092-uftc8inx 5600 7 is be VBZ cord-010092-uftc8inx 5600 8 a a DT cord-010092-uftc8inx 5600 9 mosquito mosquito NN cord-010092-uftc8inx 5600 10 transmissible transmissible JJ cord-010092-uftc8inx 5600 11 flavivirus flavivirus NNP cord-010092-uftc8inx 5600 12 . . . cord-010092-uftc8inx 5601 1 It -PRON- PRP cord-010092-uftc8inx 5601 2 has have VBZ cord-010092-uftc8inx 5601 3 been be VBN cord-010092-uftc8inx 5601 4 shown show VBN cord-010092-uftc8inx 5601 5 ( ( -LRB- cord-010092-uftc8inx 5601 6 Vogels Vogels NNP cord-010092-uftc8inx 5601 7 2017 2017 CD cord-010092-uftc8inx 5601 8 Thesis Thesis NNP cord-010092-uftc8inx 5601 9 ) ) -RRB- cord-010092-uftc8inx 5601 10 that that IN cord-010092-uftc8inx 5601 11 the the DT cord-010092-uftc8inx 5601 12 common common JJ cord-010092-uftc8inx 5601 13 mosquito mosquito NN cord-010092-uftc8inx 5601 14 in in IN cord-010092-uftc8inx 5601 15 the the DT cord-010092-uftc8inx 5601 16 Netherlands Netherlands NNP cord-010092-uftc8inx 5601 17 can can MD cord-010092-uftc8inx 5601 18 transmit transmit VB cord-010092-uftc8inx 5601 19 WNV WNV NNP cord-010092-uftc8inx 5601 20 in in IN cord-010092-uftc8inx 5601 21 laboratory laboratory NN cord-010092-uftc8inx 5601 22 circumstances circumstance NNS cord-010092-uftc8inx 5601 23 but but CC cord-010092-uftc8inx 5601 24 presently presently RB cord-010092-uftc8inx 5601 25 does do VBZ cord-010092-uftc8inx 5601 26 not not RB cord-010092-uftc8inx 5601 27 lead lead VB cord-010092-uftc8inx 5601 28 to to IN cord-010092-uftc8inx 5601 29 effective effective JJ cord-010092-uftc8inx 5601 30 transmission transmission NN cord-010092-uftc8inx 5601 31 . . . cord-010092-uftc8inx 5602 1 However however RB cord-010092-uftc8inx 5602 2 , , , cord-010092-uftc8inx 5602 3 the the DT cord-010092-uftc8inx 5602 4 number number NN cord-010092-uftc8inx 5602 5 of of IN cord-010092-uftc8inx 5602 6 outbreaks outbreak NNS cord-010092-uftc8inx 5602 7 of of IN cord-010092-uftc8inx 5602 8 WNV WNV NNP cord-010092-uftc8inx 5602 9 is be VBZ cord-010092-uftc8inx 5602 10 increasing increase VBG cord-010092-uftc8inx 5602 11 and and CC cord-010092-uftc8inx 5602 12 moving move VBG cord-010092-uftc8inx 5602 13 from from IN cord-010092-uftc8inx 5602 14 the the DT cord-010092-uftc8inx 5602 15 Eastern eastern JJ cord-010092-uftc8inx 5602 16 and and CC cord-010092-uftc8inx 5602 17 Southern southern JJ cord-010092-uftc8inx 5602 18 European european JJ cord-010092-uftc8inx 5602 19 borders border NNS cord-010092-uftc8inx 5602 20 towards towards IN cord-010092-uftc8inx 5602 21 the the DT cord-010092-uftc8inx 5602 22 traditionally traditionally RB cord-010092-uftc8inx 5602 23 more more RBR cord-010092-uftc8inx 5602 24 colder cold JJR cord-010092-uftc8inx 5602 25 Western western JJ cord-010092-uftc8inx 5602 26 and and CC cord-010092-uftc8inx 5602 27 Northern northern JJ cord-010092-uftc8inx 5602 28 parts part NNS cord-010092-uftc8inx 5602 29 of of IN cord-010092-uftc8inx 5602 30 Europe Europe NNP cord-010092-uftc8inx 5602 31 . . . cord-010092-uftc8inx 5603 1 In in IN cord-010092-uftc8inx 5603 2 order order NN cord-010092-uftc8inx 5603 3 to to TO cord-010092-uftc8inx 5603 4 prevent prevent VB cord-010092-uftc8inx 5603 5 WNV WNV NNP cord-010092-uftc8inx 5603 6 transmission transmission NN cord-010092-uftc8inx 5603 7 to to IN cord-010092-uftc8inx 5603 8 blood blood NN cord-010092-uftc8inx 5603 9 transfusion transfusion NN cord-010092-uftc8inx 5603 10 recipients recipient NNS cord-010092-uftc8inx 5603 11 , , , cord-010092-uftc8inx 5603 12 Dutch dutch JJ cord-010092-uftc8inx 5603 13 donors donor NNS cord-010092-uftc8inx 5603 14 that that WDT cord-010092-uftc8inx 5603 15 travelled travel VBD cord-010092-uftc8inx 5603 16 to to IN cord-010092-uftc8inx 5603 17 regions region NNS cord-010092-uftc8inx 5603 18 with with IN cord-010092-uftc8inx 5603 19 WNV WNV NNP cord-010092-uftc8inx 5603 20 risk risk NN cord-010092-uftc8inx 5603 21 are be VBP cord-010092-uftc8inx 5603 22 deferred defer VBN cord-010092-uftc8inx 5603 23 for for IN cord-010092-uftc8inx 5603 24 a a DT cord-010092-uftc8inx 5603 25 period period NN cord-010092-uftc8inx 5603 26 of of IN cord-010092-uftc8inx 5603 27 28 28 CD cord-010092-uftc8inx 5603 28 days day NNS cord-010092-uftc8inx 5603 29 for for IN cord-010092-uftc8inx 5603 30 whole whole JJ cord-010092-uftc8inx 5603 31 blood blood NN cord-010092-uftc8inx 5603 32 , , , cord-010092-uftc8inx 5603 33 platelet platelet NN cord-010092-uftc8inx 5603 34 donations donation NNS cord-010092-uftc8inx 5603 35 and and CC cord-010092-uftc8inx 5603 36 quarantine quarantine NN cord-010092-uftc8inx 5603 37 plasma plasma NN cord-010092-uftc8inx 5603 38 in in IN cord-010092-uftc8inx 5603 39 order order NN cord-010092-uftc8inx 5603 40 to to TO cord-010092-uftc8inx 5603 41 exclude exclude VB cord-010092-uftc8inx 5603 42 potentially potentially RB cord-010092-uftc8inx 5603 43 infected infected JJ cord-010092-uftc8inx 5603 44 asymptomatic asymptomatic JJ cord-010092-uftc8inx 5603 45 donors donor NNS cord-010092-uftc8inx 5603 46 . . . cord-010092-uftc8inx 5604 1 Aims aim VBZ cord-010092-uftc8inx 5604 2 : : : cord-010092-uftc8inx 5605 1 To to TO cord-010092-uftc8inx 5605 2 assess assess VB cord-010092-uftc8inx 5605 3 numbers number NNS cord-010092-uftc8inx 5605 4 of of IN cord-010092-uftc8inx 5605 5 Dutch dutch JJ cord-010092-uftc8inx 5605 6 donors donor NNS cord-010092-uftc8inx 5605 7 who who WP cord-010092-uftc8inx 5605 8 are be VBP cord-010092-uftc8inx 5605 9 deferred defer VBN cord-010092-uftc8inx 5605 10 for for IN cord-010092-uftc8inx 5605 11 travelling travel VBG cord-010092-uftc8inx 5605 12 to to IN cord-010092-uftc8inx 5605 13 WNV WNV NNP cord-010092-uftc8inx 5605 14 risk risk NN cord-010092-uftc8inx 5605 15 areas area NNS cord-010092-uftc8inx 5605 16 within within IN cord-010092-uftc8inx 5605 17 Europe Europe NNP cord-010092-uftc8inx 5605 18 , , , cord-010092-uftc8inx 5605 19 and and CC cord-010092-uftc8inx 5605 20 the the DT cord-010092-uftc8inx 5605 21 return return NN cord-010092-uftc8inx 5605 22 after after IN cord-010092-uftc8inx 5605 23 onsite onsite JJ cord-010092-uftc8inx 5605 24 and and CC cord-010092-uftc8inx 5605 25 offsite offsite JJ cord-010092-uftc8inx 5605 26 deferrals deferral NNS cord-010092-uftc8inx 5605 27 of of IN cord-010092-uftc8inx 5605 28 donors donor NNS cord-010092-uftc8inx 5605 29 . . . cord-010092-uftc8inx 5606 1 Methods method NNS cord-010092-uftc8inx 5606 2 : : : cord-010092-uftc8inx 5606 3 Data datum NNS cord-010092-uftc8inx 5606 4 from from IN cord-010092-uftc8inx 5606 5 2015 2015 CD cord-010092-uftc8inx 5606 6 to to IN cord-010092-uftc8inx 5606 7 2018 2018 CD cord-010092-uftc8inx 5606 8 on on IN cord-010092-uftc8inx 5606 9 donation donation NN cord-010092-uftc8inx 5606 10 attempts attempt NNS cord-010092-uftc8inx 5606 11 and and CC cord-010092-uftc8inx 5606 12 deferral deferral NN cord-010092-uftc8inx 5606 13 were be VBD cord-010092-uftc8inx 5606 14 retrieved retrieve VBN cord-010092-uftc8inx 5606 15 from from IN cord-010092-uftc8inx 5606 16 eProgesa eProgesa NNP cord-010092-uftc8inx 5606 17 , , , cord-010092-uftc8inx 5606 18 the the DT cord-010092-uftc8inx 5606 19 blood blood NN cord-010092-uftc8inx 5606 20 bank bank NN cord-010092-uftc8inx 5606 21 information information NN cord-010092-uftc8inx 5606 22 system system NN cord-010092-uftc8inx 5606 23 . . . cord-010092-uftc8inx 5607 1 Onsite onsite JJ cord-010092-uftc8inx 5607 2 deferral deferral NN cord-010092-uftc8inx 5607 3 is be VBZ cord-010092-uftc8inx 5607 4 defined define VBN cord-010092-uftc8inx 5607 5 as as IN cord-010092-uftc8inx 5607 6 a a DT cord-010092-uftc8inx 5607 7 donation donation NN cord-010092-uftc8inx 5607 8 that that WDT cord-010092-uftc8inx 5607 9 was be VBD cord-010092-uftc8inx 5607 10 attempted attempt VBN cord-010092-uftc8inx 5607 11 in in IN cord-010092-uftc8inx 5607 12 the the DT cord-010092-uftc8inx 5607 13 deferral deferral NN cord-010092-uftc8inx 5607 14 period period NN cord-010092-uftc8inx 5607 15 or or CC cord-010092-uftc8inx 5607 16 in in IN cord-010092-uftc8inx 5607 17 the the DT cord-010092-uftc8inx 5607 18 7 7 CD cord-010092-uftc8inx 5607 19 days day NNS cord-010092-uftc8inx 5607 20 prior prior RB cord-010092-uftc8inx 5607 21 to to IN cord-010092-uftc8inx 5607 22 deferral deferral NN cord-010092-uftc8inx 5607 23 , , , cord-010092-uftc8inx 5607 24 all all DT cord-010092-uftc8inx 5607 25 other other JJ cord-010092-uftc8inx 5607 26 deferrals deferral NNS cord-010092-uftc8inx 5607 27 are be VBP cord-010092-uftc8inx 5607 28 considered consider VBN cord-010092-uftc8inx 5607 29 as as IN cord-010092-uftc8inx 5607 30 offsite offsite JJ cord-010092-uftc8inx 5607 31 . . . cord-010092-uftc8inx 5608 1 A a DT cord-010092-uftc8inx 5608 2 Generalized generalized JJ cord-010092-uftc8inx 5608 3 Estimating Estimating NNP cord-010092-uftc8inx 5608 4 Equation Equation NNP cord-010092-uftc8inx 5608 5 model model NN cord-010092-uftc8inx 5608 6 was be VBD cord-010092-uftc8inx 5608 7 used use VBN cord-010092-uftc8inx 5608 8 to to TO cord-010092-uftc8inx 5608 9 assess assess VB cord-010092-uftc8inx 5608 10 the the DT cord-010092-uftc8inx 5608 11 association association NN cord-010092-uftc8inx 5608 12 between between IN cord-010092-uftc8inx 5608 13 onsite onsite JJ cord-010092-uftc8inx 5608 14 versus versus IN cord-010092-uftc8inx 5608 15 offsite offsite JJ cord-010092-uftc8inx 5608 16 WNV WNV NNP cord-010092-uftc8inx 5608 17 risk risk NN cord-010092-uftc8inx 5608 18 deferrals deferral NNS cord-010092-uftc8inx 5608 19 in in IN cord-010092-uftc8inx 5608 20 2015 2015 CD cord-010092-uftc8inx 5608 21 - - SYM cord-010092-uftc8inx 5608 22 2016 2016 CD cord-010092-uftc8inx 5608 23 and and CC cord-010092-uftc8inx 5608 24 subsequent subsequent JJ cord-010092-uftc8inx 5608 25 return return NN cord-010092-uftc8inx 5608 26 rates rate NNS cord-010092-uftc8inx 5608 27 within within IN cord-010092-uftc8inx 5608 28 two two CD cord-010092-uftc8inx 5608 29 years year NNS cord-010092-uftc8inx 5608 30 ( ( -LRB- cord-010092-uftc8inx 5608 31 after after IN cord-010092-uftc8inx 5608 32 which which WDT cord-010092-uftc8inx 5608 33 a a DT cord-010092-uftc8inx 5608 34 donor donor NN cord-010092-uftc8inx 5608 35 is be VBZ cord-010092-uftc8inx 5608 36 inactive inactive JJ cord-010092-uftc8inx 5608 37 according accord VBG cord-010092-uftc8inx 5608 38 to to IN cord-010092-uftc8inx 5608 39 DOMAINE DOMAINE NNP cord-010092-uftc8inx 5608 40 ) ) -RRB- cord-010092-uftc8inx 5608 41 . . . cord-010092-uftc8inx 5609 1 Results result NNS cord-010092-uftc8inx 5609 2 : : : cord-010092-uftc8inx 5610 1 In in IN cord-010092-uftc8inx 5610 2 2015 2015 CD cord-010092-uftc8inx 5610 3 - - SYM cord-010092-uftc8inx 5610 4 2018 2018 CD cord-010092-uftc8inx 5610 5 , , , cord-010092-uftc8inx 5610 6 16,400 16,400 CD cord-010092-uftc8inx 5610 7 donation donation NN cord-010092-uftc8inx 5610 8 attempts attempt NNS cord-010092-uftc8inx 5610 9 led lead VBN cord-010092-uftc8inx 5610 10 to to IN cord-010092-uftc8inx 5610 11 onsite onsite JJ cord-010092-uftc8inx 5610 12 deferral deferral NN cord-010092-uftc8inx 5610 13 for for IN cord-010092-uftc8inx 5610 14 WNV WNV NNP cord-010092-uftc8inx 5610 15 risk risk NN cord-010092-uftc8inx 5610 16 ; ; : cord-010092-uftc8inx 5610 17 87 87 CD cord-010092-uftc8inx 5610 18 % % NN cord-010092-uftc8inx 5610 19 at at IN cord-010092-uftc8inx 5610 20 whole whole JJ cord-010092-uftc8inx 5610 21 blood blood NN cord-010092-uftc8inx 5610 22 donation donation NN cord-010092-uftc8inx 5610 23 attempts attempt NNS cord-010092-uftc8inx 5610 24 , , , cord-010092-uftc8inx 5610 25 13 13 CD cord-010092-uftc8inx 5610 26 % % NN cord-010092-uftc8inx 5610 27 at at IN cord-010092-uftc8inx 5610 28 new new JJ cord-010092-uftc8inx 5610 29 donor donor NN cord-010092-uftc8inx 5610 30 examinations examination NNS cord-010092-uftc8inx 5610 31 . . . cord-010092-uftc8inx 5611 1 In in IN cord-010092-uftc8inx 5611 2 total total JJ cord-010092-uftc8inx 5611 3 19,624 19,624 CD cord-010092-uftc8inx 5611 4 offsite offsite JJ cord-010092-uftc8inx 5611 5 deferrals deferral NNS cord-010092-uftc8inx 5611 6 could could MD cord-010092-uftc8inx 5611 7 not not RB cord-010092-uftc8inx 5611 8 be be VB cord-010092-uftc8inx 5611 9 traced trace VBN cord-010092-uftc8inx 5611 10 directly directly RB cord-010092-uftc8inx 5611 11 to to IN cord-010092-uftc8inx 5611 12 a a DT cord-010092-uftc8inx 5611 13 donation donation NN cord-010092-uftc8inx 5611 14 , , , cord-010092-uftc8inx 5611 15 but but CC cord-010092-uftc8inx 5611 16 based base VBN cord-010092-uftc8inx 5611 17 on on IN cord-010092-uftc8inx 5611 18 the the DT cord-010092-uftc8inx 5611 19 next next JJ cord-010092-uftc8inx 5611 20 donation donation NN cord-010092-uftc8inx 5611 21 more more JJR cord-010092-uftc8inx 5611 22 than than IN cord-010092-uftc8inx 5611 23 90 90 CD cord-010092-uftc8inx 5611 24 % % NN cord-010092-uftc8inx 5611 25 were be VBD cord-010092-uftc8inx 5611 26 probably probably RB cord-010092-uftc8inx 5611 27 whole whole JJ cord-010092-uftc8inx 5611 28 blood blood NN cord-010092-uftc8inx 5611 29 donors donor NNS cord-010092-uftc8inx 5611 30 . . . cord-010092-uftc8inx 5612 1 The the DT cord-010092-uftc8inx 5612 2 number number NN cord-010092-uftc8inx 5612 3 of of IN cord-010092-uftc8inx 5612 4 deferrals deferral NNS cord-010092-uftc8inx 5612 5 peaks peak NNS cord-010092-uftc8inx 5612 6 each each DT cord-010092-uftc8inx 5612 7 year year NN cord-010092-uftc8inx 5612 8 during during IN cord-010092-uftc8inx 5612 9 August August NNP cord-010092-uftc8inx 5612 10 , , , cord-010092-uftc8inx 5612 11 the the DT cord-010092-uftc8inx 5612 12 major major JJ cord-010092-uftc8inx 5612 13 holiday holiday NN cord-010092-uftc8inx 5612 14 period period NN cord-010092-uftc8inx 5612 15 in in IN cord-010092-uftc8inx 5612 16 the the DT cord-010092-uftc8inx 5612 17 Netherlands Netherlands NNP cord-010092-uftc8inx 5612 18 , , , cord-010092-uftc8inx 5612 19 and and CC cord-010092-uftc8inx 5612 20 increased increase VBD cord-010092-uftc8inx 5612 21 from from IN cord-010092-uftc8inx 5612 22 920 920 CD cord-010092-uftc8inx 5612 23 in in IN cord-010092-uftc8inx 5612 24 August August NNP cord-010092-uftc8inx 5612 25 2015 2015 CD cord-010092-uftc8inx 5612 26 to to IN cord-010092-uftc8inx 5612 27 1711 1711 CD cord-010092-uftc8inx 5612 28 in in IN cord-010092-uftc8inx 5612 29 August August NNP cord-010092-uftc8inx 5612 30 2018 2018 CD cord-010092-uftc8inx 5612 31 . . . cord-010092-uftc8inx 5613 1 This this DT cord-010092-uftc8inx 5613 2 increase increase NN cord-010092-uftc8inx 5613 3 is be VBZ cord-010092-uftc8inx 5613 4 probably probably RB cord-010092-uftc8inx 5613 5 caused cause VBN cord-010092-uftc8inx 5613 6 by by IN cord-010092-uftc8inx 5613 7 the the DT cord-010092-uftc8inx 5613 8 expansion expansion NN cord-010092-uftc8inx 5613 9 of of IN cord-010092-uftc8inx 5613 10 WNV WNV NNP cord-010092-uftc8inx 5613 11 risk risk NN cord-010092-uftc8inx 5613 12 regions region NNS cord-010092-uftc8inx 5613 13 . . . cord-010092-uftc8inx 5614 1 The the DT cord-010092-uftc8inx 5614 2 return return NN cord-010092-uftc8inx 5614 3 rate rate NN cord-010092-uftc8inx 5614 4 of of IN cord-010092-uftc8inx 5614 5 WNV WNV NNP cord-010092-uftc8inx 5614 6 deferred defer VBD cord-010092-uftc8inx 5614 7 whole whole JJ cord-010092-uftc8inx 5614 8 blood blood NN cord-010092-uftc8inx 5614 9 donors donor NNS cord-010092-uftc8inx 5614 10 is be VBZ cord-010092-uftc8inx 5614 11 slightly slightly RB cord-010092-uftc8inx 5614 12 lower low JJR cord-010092-uftc8inx 5614 13 than than IN cord-010092-uftc8inx 5614 14 for for IN cord-010092-uftc8inx 5614 15 donors donor NNS cord-010092-uftc8inx 5614 16 who who WP cord-010092-uftc8inx 5614 17 are be VBP cord-010092-uftc8inx 5614 18 not not RB cord-010092-uftc8inx 5614 19 deferred defer VBN cord-010092-uftc8inx 5614 20 ( ( -LRB- cord-010092-uftc8inx 5614 21 92 92 CD cord-010092-uftc8inx 5614 22 % % NN cord-010092-uftc8inx 5614 23 versus versus IN cord-010092-uftc8inx 5614 24 95 95 CD cord-010092-uftc8inx 5614 25 % % NN cord-010092-uftc8inx 5614 26 ) ) -RRB- cord-010092-uftc8inx 5614 27 ; ; : cord-010092-uftc8inx 5614 28 for for IN cord-010092-uftc8inx 5614 29 WNV WNV NNP cord-010092-uftc8inx 5614 30 deferred defer VBD cord-010092-uftc8inx 5614 31 new new JJ cord-010092-uftc8inx 5614 32 donors donor NNS cord-010092-uftc8inx 5615 1 the the DT cord-010092-uftc8inx 5615 2 return return NN cord-010092-uftc8inx 5615 3 rate rate NN cord-010092-uftc8inx 5615 4 is be VBZ cord-010092-uftc8inx 5615 5 75 75 CD cord-010092-uftc8inx 5615 6 % % NN cord-010092-uftc8inx 5615 7 ( ( -LRB- cord-010092-uftc8inx 5615 8 versus versus IN cord-010092-uftc8inx 5615 9 87 87 CD cord-010092-uftc8inx 5615 10 % % NN cord-010092-uftc8inx 5615 11 for for IN cord-010092-uftc8inx 5615 12 no no DT cord-010092-uftc8inx 5615 13 deferral deferral NN cord-010092-uftc8inx 5615 14 ) ) -RRB- cord-010092-uftc8inx 5615 15 . . . cord-010092-uftc8inx 5616 1 Thus thus RB cord-010092-uftc8inx 5616 2 WNV WNV NNP cord-010092-uftc8inx 5616 3 deferral deferral NN cord-010092-uftc8inx 5616 4 resulted result VBD cord-010092-uftc8inx 5616 5 in in IN cord-010092-uftc8inx 5616 6 approximately approximately RB cord-010092-uftc8inx 5616 7 400 400 CD cord-010092-uftc8inx 5616 8 - - SYM cord-010092-uftc8inx 5616 9 500 500 CD cord-010092-uftc8inx 5616 10 extra extra JJ cord-010092-uftc8inx 5616 11 lapsing lapse VBG cord-010092-uftc8inx 5616 12 donors donor NNS cord-010092-uftc8inx 5616 13 during during IN cord-010092-uftc8inx 5616 14 these these DT cord-010092-uftc8inx 5616 15 2 2 CD cord-010092-uftc8inx 5616 16 years year NNS cord-010092-uftc8inx 5616 17 . . . cord-010092-uftc8inx 5617 1 However however RB cord-010092-uftc8inx 5617 2 WNV WNV NNP cord-010092-uftc8inx 5617 3 deferred defer VBN cord-010092-uftc8inx 5617 4 donors donor NNS cord-010092-uftc8inx 5617 5 , , , cord-010092-uftc8inx 5617 6 that that WDT cord-010092-uftc8inx 5617 7 are be VBP cord-010092-uftc8inx 5617 8 older old JJR cord-010092-uftc8inx 5617 9 ( ( -LRB- cord-010092-uftc8inx 5617 10 odds odd NNS cord-010092-uftc8inx 5617 11 ratio ratio NN cord-010092-uftc8inx 5617 12 ( ( -LRB- cord-010092-uftc8inx 5617 13 OR OR NNP cord-010092-uftc8inx 5617 14 ) ) -RRB- cord-010092-uftc8inx 5617 15 1.03 1.03 CD cord-010092-uftc8inx 5617 16 ; ; : cord-010092-uftc8inx 5617 17 95 95 CD cord-010092-uftc8inx 5617 18 % % NN cord-010092-uftc8inx 5617 19 Confidence confidence NN cord-010092-uftc8inx 5617 20 Interval interval NN cord-010092-uftc8inx 5617 21 ( ( -LRB- cord-010092-uftc8inx 5617 22 95 95 CD cord-010092-uftc8inx 5617 23 % % NN cord-010092-uftc8inx 5617 24 CI ci NN cord-010092-uftc8inx 5617 25 ) ) -RRB- cord-010092-uftc8inx 5618 1 1.02 1.02 CD cord-010092-uftc8inx 5618 2 - - SYM cord-010092-uftc8inx 5618 3 1.03 1.03 CD cord-010092-uftc8inx 5618 4 ) ) -RRB- cord-010092-uftc8inx 5618 5 , , , cord-010092-uftc8inx 5618 6 of of IN cord-010092-uftc8inx 5618 7 male male JJ cord-010092-uftc8inx 5618 8 sex sex NN cord-010092-uftc8inx 5618 9 ( ( -LRB- cord-010092-uftc8inx 5618 10 OR or CC cord-010092-uftc8inx 5618 11 1.16 1.16 CD cord-010092-uftc8inx 5618 12 ; ; : cord-010092-uftc8inx 5618 13 95 95 CD cord-010092-uftc8inx 5618 14 % % NN cord-010092-uftc8inx 5618 15 CI CI NNP cord-010092-uftc8inx 5618 16 1.03 1.03 CD cord-010092-uftc8inx 5618 17 - - SYM cord-010092-uftc8inx 5618 18 1.31 1.31 CD cord-010092-uftc8inx 5618 19 ) ) -RRB- cord-010092-uftc8inx 5618 20 and and CC cord-010092-uftc8inx 5618 21 whole whole JJ cord-010092-uftc8inx 5618 22 blood blood NN cord-010092-uftc8inx 5618 23 donors donor NNS cord-010092-uftc8inx 5618 24 as as IN cord-010092-uftc8inx 5618 25 opposed oppose VBN cord-010092-uftc8inx 5618 26 to to IN cord-010092-uftc8inx 5618 27 new new JJ cord-010092-uftc8inx 5618 28 donors donor NNS cord-010092-uftc8inx 5618 29 ( ( -LRB- cord-010092-uftc8inx 5618 30 OR or CC cord-010092-uftc8inx 5618 31 2.01 2.01 CD cord-010092-uftc8inx 5618 32 ; ; : cord-010092-uftc8inx 5618 33 95 95 CD cord-010092-uftc8inx 5618 34 % % NN cord-010092-uftc8inx 5618 35 CI CI NNP cord-010092-uftc8inx 5618 36 1.70 1.70 CD cord-010092-uftc8inx 5618 37 - - HYPH cord-010092-uftc8inx 5618 38 2.38 2.38 CD cord-010092-uftc8inx 5618 39 ) ) -RRB- cord-010092-uftc8inx 5618 40 were be VBD cord-010092-uftc8inx 5618 41 more more RBR cord-010092-uftc8inx 5618 42 likely likely JJ cord-010092-uftc8inx 5618 43 to to TO cord-010092-uftc8inx 5618 44 return return VB cord-010092-uftc8inx 5618 45 to to TO cord-010092-uftc8inx 5618 46 donate donate VB cord-010092-uftc8inx 5618 47 . . . cord-010092-uftc8inx 5619 1 There there EX cord-010092-uftc8inx 5619 2 was be VBD cord-010092-uftc8inx 5619 3 no no DT cord-010092-uftc8inx 5619 4 difference difference NN cord-010092-uftc8inx 5619 5 in in IN cord-010092-uftc8inx 5619 6 return return NN cord-010092-uftc8inx 5619 7 rate rate NN cord-010092-uftc8inx 5619 8 by by IN cord-010092-uftc8inx 5619 9 offsite offsite JJ cord-010092-uftc8inx 5619 10 and and CC cord-010092-uftc8inx 5619 11 onsite onsite JJ cord-010092-uftc8inx 5619 12 deferral deferral NN cord-010092-uftc8inx 5619 13 . . . cord-010092-uftc8inx 5620 1 Summary Summary NNP cord-010092-uftc8inx 5620 2 / / SYM cord-010092-uftc8inx 5620 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 5620 4 : : : cord-010092-uftc8inx 5621 1 Travel travel NN cord-010092-uftc8inx 5621 2 - - HYPH cord-010092-uftc8inx 5621 3 related relate VBN cord-010092-uftc8inx 5621 4 WNV WNV NNP cord-010092-uftc8inx 5621 5 deferrals deferral NNS cord-010092-uftc8inx 5621 6 are be VBP cord-010092-uftc8inx 5621 7 increasing increase VBG cord-010092-uftc8inx 5621 8 with with IN cord-010092-uftc8inx 5621 9 expanding expand VBG cord-010092-uftc8inx 5621 10 risk risk NN cord-010092-uftc8inx 5621 11 regions region NNS cord-010092-uftc8inx 5621 12 , , , cord-010092-uftc8inx 5621 13 especially especially RB cord-010092-uftc8inx 5621 14 in in IN cord-010092-uftc8inx 5621 15 the the DT cord-010092-uftc8inx 5621 16 holiday holiday NN cord-010092-uftc8inx 5621 17 season season NN cord-010092-uftc8inx 5621 18 where where WRB cord-010092-uftc8inx 5621 19 the the DT cord-010092-uftc8inx 5621 20 availability availability NN cord-010092-uftc8inx 5621 21 of of IN cord-010092-uftc8inx 5621 22 donors donor NNS cord-010092-uftc8inx 5621 23 is be VBZ cord-010092-uftc8inx 5621 24 already already RB cord-010092-uftc8inx 5621 25 low low JJ cord-010092-uftc8inx 5621 26 . . . cord-010092-uftc8inx 5622 1 Although although IN cord-010092-uftc8inx 5622 2 the the DT cord-010092-uftc8inx 5622 3 numbers number NNS cord-010092-uftc8inx 5622 4 of of IN cord-010092-uftc8inx 5622 5 donors donor NNS cord-010092-uftc8inx 5622 6 who who WP cord-010092-uftc8inx 5622 7 are be VBP cord-010092-uftc8inx 5622 8 permanently permanently RB cord-010092-uftc8inx 5622 9 lost lose VBN cord-010092-uftc8inx 5622 10 after after IN cord-010092-uftc8inx 5622 11 WNV WNV NNP cord-010092-uftc8inx 5622 12 deferral deferral NN cord-010092-uftc8inx 5622 13 are be VBP cord-010092-uftc8inx 5622 14 limited limit VBN cord-010092-uftc8inx 5622 15 , , , cord-010092-uftc8inx 5622 16 the the DT cord-010092-uftc8inx 5622 17 increasing increase VBG cord-010092-uftc8inx 5622 18 numbers number NNS cord-010092-uftc8inx 5622 19 of of IN cord-010092-uftc8inx 5622 20 lost lose VBN cord-010092-uftc8inx 5622 21 donations donation NNS cord-010092-uftc8inx 5622 22 make make VBP cord-010092-uftc8inx 5622 23 it -PRON- PRP cord-010092-uftc8inx 5622 24 important important JJ cord-010092-uftc8inx 5622 25 to to TO cord-010092-uftc8inx 5622 26 consider consider VB cord-010092-uftc8inx 5622 27 alternatives alternative NNS cord-010092-uftc8inx 5622 28 to to IN cord-010092-uftc8inx 5622 29 donor donor NN cord-010092-uftc8inx 5622 30 deferral deferral NN cord-010092-uftc8inx 5622 31 such such JJ cord-010092-uftc8inx 5622 32 as as IN cord-010092-uftc8inx 5622 33 WNV WNV NNP cord-010092-uftc8inx 5622 34 NAT NAT NNP cord-010092-uftc8inx 5622 35 testing testing NN cord-010092-uftc8inx 5622 36 . . . cord-010092-uftc8inx 5623 1 Background background NN cord-010092-uftc8inx 5623 2 : : : cord-010092-uftc8inx 5624 1 Low low JJ cord-010092-uftc8inx 5624 2 haemoglobin haemoglobin NN cord-010092-uftc8inx 5624 3 due due JJ cord-010092-uftc8inx 5624 4 to to IN cord-010092-uftc8inx 5624 5 iron iron NN cord-010092-uftc8inx 5624 6 deficiency deficiency NN cord-010092-uftc8inx 5624 7 is be VBZ cord-010092-uftc8inx 5624 8 increasingly increasingly RB cord-010092-uftc8inx 5624 9 recognized recognize VBN cord-010092-uftc8inx 5624 10 as as IN cord-010092-uftc8inx 5624 11 a a DT cord-010092-uftc8inx 5624 12 serious serious JJ cord-010092-uftc8inx 5624 13 problem problem NN cord-010092-uftc8inx 5624 14 in in IN cord-010092-uftc8inx 5624 15 many many JJ cord-010092-uftc8inx 5624 16 blood blood NN cord-010092-uftc8inx 5624 17 centers center NNS cord-010092-uftc8inx 5624 18 . . . cord-010092-uftc8inx 5625 1 Donor donor NN cord-010092-uftc8inx 5625 2 education education NN cord-010092-uftc8inx 5625 3 , , , cord-010092-uftc8inx 5625 4 iron iron NN cord-010092-uftc8inx 5625 5 supplementation supplementation NN cord-010092-uftc8inx 5625 6 , , , cord-010092-uftc8inx 5625 7 ferritin ferritin NN cord-010092-uftc8inx 5625 8 monitoring monitoring NN cord-010092-uftc8inx 5625 9 , , , cord-010092-uftc8inx 5625 10 and and CC cord-010092-uftc8inx 5625 11 lengthening lengthening NN cord-010092-uftc8inx 5625 12 of of IN cord-010092-uftc8inx 5625 13 inter inter JJ cord-010092-uftc8inx 5625 14 - - JJ cord-010092-uftc8inx 5625 15 donation donation NN cord-010092-uftc8inx 5625 16 interval interval NN cord-010092-uftc8inx 5625 17 are be VBP cord-010092-uftc8inx 5625 18 currently currently RB cord-010092-uftc8inx 5625 19 the the DT cord-010092-uftc8inx 5625 20 main main JJ cord-010092-uftc8inx 5625 21 mitigation mitigation NN cord-010092-uftc8inx 5625 22 measures measure NNS cord-010092-uftc8inx 5625 23 . . . cord-010092-uftc8inx 5626 1 However however RB cord-010092-uftc8inx 5626 2 , , , cord-010092-uftc8inx 5626 3 a a DT cord-010092-uftc8inx 5626 4 number number NN cord-010092-uftc8inx 5626 5 of of IN cord-010092-uftc8inx 5626 6 factors factor NNS cord-010092-uftc8inx 5626 7 in in IN cord-010092-uftc8inx 5626 8 particular particular JJ cord-010092-uftc8inx 5626 9 donor donor NN cord-010092-uftc8inx 5626 10 knowledge knowledge NN cord-010092-uftc8inx 5626 11 could could MD cord-010092-uftc8inx 5626 12 impact impact VB cord-010092-uftc8inx 5626 13 their -PRON- PRP$ cord-010092-uftc8inx 5626 14 success success NN cord-010092-uftc8inx 5626 15 . . . cord-010092-uftc8inx 5627 1 Locally locally RB cord-010092-uftc8inx 5627 2 , , , cord-010092-uftc8inx 5627 3 iron iron NN cord-010092-uftc8inx 5627 4 supplementation supplementation NN cord-010092-uftc8inx 5627 5 programme programme NN cord-010092-uftc8inx 5627 6 was be VBD cord-010092-uftc8inx 5627 7 implemented implement VBN cord-010092-uftc8inx 5627 8 since since IN cord-010092-uftc8inx 5627 9 2012 2012 CD cord-010092-uftc8inx 5627 10 with with IN cord-010092-uftc8inx 5627 11 target target NN cord-010092-uftc8inx 5627 12 group group NN cord-010092-uftc8inx 5627 13 of of IN cord-010092-uftc8inx 5627 14 donors donor NNS cord-010092-uftc8inx 5627 15 who who WP cord-010092-uftc8inx 5627 16 have have VBP cord-010092-uftc8inx 5627 17 given give VBN cord-010092-uftc8inx 5627 18 blood blood NN cord-010092-uftc8inx 5627 19 within within IN cord-010092-uftc8inx 5627 20 the the DT cord-010092-uftc8inx 5627 21 last last JJ cord-010092-uftc8inx 5627 22 six six CD cord-010092-uftc8inx 5627 23 months month NNS cord-010092-uftc8inx 5627 24 . . . cord-010092-uftc8inx 5628 1 Aims aim VBZ cord-010092-uftc8inx 5628 2 : : : cord-010092-uftc8inx 5629 1 Here here RB cord-010092-uftc8inx 5629 2 we -PRON- PRP cord-010092-uftc8inx 5629 3 look look VBP cord-010092-uftc8inx 5629 4 at at IN cord-010092-uftc8inx 5629 5 an an DT cord-010092-uftc8inx 5629 6 online online JJ cord-010092-uftc8inx 5629 7 donor donor NN cord-010092-uftc8inx 5629 8 survey survey NN cord-010092-uftc8inx 5629 9 to to TO cord-010092-uftc8inx 5629 10 gain gain VB cord-010092-uftc8inx 5629 11 insight insight NN cord-010092-uftc8inx 5629 12 on on IN cord-010092-uftc8inx 5629 13 their -PRON- PRP$ cord-010092-uftc8inx 5629 14 view view NN cord-010092-uftc8inx 5629 15 of of IN cord-010092-uftc8inx 5629 16 the the DT cord-010092-uftc8inx 5629 17 programme programme NN cord-010092-uftc8inx 5629 18 and and CC cord-010092-uftc8inx 5629 19 knowledge knowledge NN cord-010092-uftc8inx 5629 20 . . . cord-010092-uftc8inx 5630 1 Methods method NNS cord-010092-uftc8inx 5630 2 : : : cord-010092-uftc8inx 5630 3 Donors donor NNS cord-010092-uftc8inx 5630 4 with with IN cord-010092-uftc8inx 5630 5 successful successful JJ cord-010092-uftc8inx 5630 6 blood blood NN cord-010092-uftc8inx 5630 7 donation donation NN cord-010092-uftc8inx 5630 8 in in IN cord-010092-uftc8inx 5630 9 the the DT cord-010092-uftc8inx 5630 10 past past JJ cord-010092-uftc8inx 5630 11 six six CD cord-010092-uftc8inx 5630 12 months month NNS cord-010092-uftc8inx 5630 13 would would MD cord-010092-uftc8inx 5630 14 be be VB cord-010092-uftc8inx 5630 15 given give VBN cord-010092-uftc8inx 5630 16 14 14 CD cord-010092-uftc8inx 5630 17 days day NNS cord-010092-uftc8inx 5630 18 of of IN cord-010092-uftc8inx 5630 19 one one CD cord-010092-uftc8inx 5630 20 tablet tablet NN cord-010092-uftc8inx 5630 21 of of IN cord-010092-uftc8inx 5630 22 iron iron NN cord-010092-uftc8inx 5630 23 supplementation supplementation NN cord-010092-uftc8inx 5630 24 ( ( -LRB- cord-010092-uftc8inx 5630 25 100 100 CD cord-010092-uftc8inx 5630 26 mg mg NNP cord-010092-uftc8inx 5630 27 elemental elemental JJ cord-010092-uftc8inx 5630 28 iron iron NN cord-010092-uftc8inx 5630 29 ) ) -RRB- cord-010092-uftc8inx 5630 30 since since IN cord-010092-uftc8inx 5630 31 2012 2012 CD cord-010092-uftc8inx 5630 32 . . . cord-010092-uftc8inx 5631 1 An an DT cord-010092-uftc8inx 5631 2 electronic electronic JJ cord-010092-uftc8inx 5631 3 questionnaire questionnaire NN cord-010092-uftc8inx 5631 4 was be VBD cord-010092-uftc8inx 5631 5 sent send VBN cord-010092-uftc8inx 5631 6 to to IN cord-010092-uftc8inx 5631 7 blood blood NN cord-010092-uftc8inx 5631 8 donors donor NNS cord-010092-uftc8inx 5631 9 in in IN cord-010092-uftc8inx 5631 10 2017 2017 CD cord-010092-uftc8inx 5631 11 to to TO cord-010092-uftc8inx 5631 12 assess assess VB cord-010092-uftc8inx 5631 13 their -PRON- PRP$ cord-010092-uftc8inx 5631 14 view view NN cord-010092-uftc8inx 5631 15 on on IN cord-010092-uftc8inx 5631 16 the the DT cord-010092-uftc8inx 5631 17 programme programme NN cord-010092-uftc8inx 5631 18 and and CC cord-010092-uftc8inx 5631 19 knowledge knowledge NN cord-010092-uftc8inx 5631 20 which which WDT cord-010092-uftc8inx 5631 21 focused focus VBD cord-010092-uftc8inx 5631 22 on on IN cord-010092-uftc8inx 5631 23 iron iron NN cord-010092-uftc8inx 5631 24 store store NN cord-010092-uftc8inx 5631 25 and and CC cord-010092-uftc8inx 5631 26 absorption absorption NN cord-010092-uftc8inx 5631 27 , , , cord-010092-uftc8inx 5631 28 compliance compliance NN cord-010092-uftc8inx 5631 29 and and CC cord-010092-uftc8inx 5631 30 any any DT cord-010092-uftc8inx 5631 31 side side NN cord-010092-uftc8inx 5631 32 effects effect NNS cord-010092-uftc8inx 5631 33 occurred occur VBD cord-010092-uftc8inx 5631 34 . . . cord-010092-uftc8inx 5632 1 Results result NNS cord-010092-uftc8inx 5632 2 : : : cord-010092-uftc8inx 5633 1 3212 3212 CD cord-010092-uftc8inx 5633 2 donors donor NNS cord-010092-uftc8inx 5633 3 ( ( -LRB- cord-010092-uftc8inx 5633 4 male male JJ cord-010092-uftc8inx 5633 5 to to IN cord-010092-uftc8inx 5633 6 female female JJ cord-010092-uftc8inx 5633 7 was be VBD cord-010092-uftc8inx 5633 8 1:1.9 1:1.9 CD cord-010092-uftc8inx 5633 9 ) ) -RRB- cord-010092-uftc8inx 5634 1 replied reply VBD cord-010092-uftc8inx 5634 2 to to IN cord-010092-uftc8inx 5634 3 the the DT cord-010092-uftc8inx 5634 4 questionnaire questionnaire NN cord-010092-uftc8inx 5634 5 . . . cord-010092-uftc8inx 5635 1 Of of IN cord-010092-uftc8inx 5635 2 them -PRON- PRP cord-010092-uftc8inx 5635 3 , , , cord-010092-uftc8inx 5635 4 594 594 CD cord-010092-uftc8inx 5635 5 received receive VBD cord-010092-uftc8inx 5635 6 iron iron NN cord-010092-uftc8inx 5635 7 supplementation supplementation NN cord-010092-uftc8inx 5635 8 ( ( -LRB- cord-010092-uftc8inx 5635 9 male male JJ cord-010092-uftc8inx 5635 10 to to IN cord-010092-uftc8inx 5635 11 female female JJ cord-010092-uftc8inx 5635 12 was be VBD cord-010092-uftc8inx 5635 13 1:1.6 1:1.6 CD cord-010092-uftc8inx 5635 14 ) ) -RRB- cord-010092-uftc8inx 5635 15 . . . cord-010092-uftc8inx 5636 1 Most Most JJS cord-010092-uftc8inx 5636 2 of of IN cord-010092-uftc8inx 5636 3 the the DT cord-010092-uftc8inx 5636 4 respondents respondent NNS cord-010092-uftc8inx 5636 5 ( ( -LRB- cord-010092-uftc8inx 5636 6 94 94 CD cord-010092-uftc8inx 5636 7 % % NN cord-010092-uftc8inx 5636 8 ) ) -RRB- cord-010092-uftc8inx 5636 9 had have VBD cord-010092-uftc8inx 5636 10 one one CD cord-010092-uftc8inx 5636 11 or or CC cord-010092-uftc8inx 5636 12 more more JJR cord-010092-uftc8inx 5636 13 donations donation NNS cord-010092-uftc8inx 5636 14 in in IN cord-010092-uftc8inx 5636 15 the the DT cord-010092-uftc8inx 5636 16 preceding precede VBG cord-010092-uftc8inx 5636 17 12 12 CD cord-010092-uftc8inx 5636 18 months month NNS cord-010092-uftc8inx 5636 19 . . . cord-010092-uftc8inx 5637 1 Of of IN cord-010092-uftc8inx 5637 2 the the DT cord-010092-uftc8inx 5637 3 594 594 CD cord-010092-uftc8inx 5637 4 donors donor NNS cord-010092-uftc8inx 5637 5 received receive VBD cord-010092-uftc8inx 5637 6 iron iron NN cord-010092-uftc8inx 5637 7 tablets tablet NNS cord-010092-uftc8inx 5637 8 , , , cord-010092-uftc8inx 5637 9 only only RB cord-010092-uftc8inx 5637 10 246 246 CD cord-010092-uftc8inx 5637 11 ( ( -LRB- cord-010092-uftc8inx 5637 12 41 41 CD cord-010092-uftc8inx 5637 13 % % NN cord-010092-uftc8inx 5637 14 ) ) -RRB- cord-010092-uftc8inx 5637 15 took take VBD cord-010092-uftc8inx 5637 16 all all DT cord-010092-uftc8inx 5637 17 ; ; : cord-010092-uftc8inx 5637 18 69 69 CD cord-010092-uftc8inx 5637 19 ( ( -LRB- cord-010092-uftc8inx 5637 20 12 12 CD cord-010092-uftc8inx 5637 21 % % NN cord-010092-uftc8inx 5637 22 ) ) -RRB- cord-010092-uftc8inx 5637 23 took take VBD cord-010092-uftc8inx 5637 24 more more JJR cord-010092-uftc8inx 5637 25 than than IN cord-010092-uftc8inx 5637 26 50 50 CD cord-010092-uftc8inx 5637 27 % % NN cord-010092-uftc8inx 5637 28 but but CC cord-010092-uftc8inx 5637 29 not not RB cord-010092-uftc8inx 5637 30 all all DT cord-010092-uftc8inx 5637 31 ; ; : cord-010092-uftc8inx 5637 32 130 130 CD cord-010092-uftc8inx 5637 33 ( ( -LRB- cord-010092-uftc8inx 5637 34 22 22 CD cord-010092-uftc8inx 5637 35 % % NN cord-010092-uftc8inx 5637 36 ) ) -RRB- cord-010092-uftc8inx 5637 37 took take VBD cord-010092-uftc8inx 5637 38 some some DT cord-010092-uftc8inx 5637 39 but but CC cord-010092-uftc8inx 5637 40 less less JJR cord-010092-uftc8inx 5637 41 than than IN cord-010092-uftc8inx 5637 42 50 50 CD cord-010092-uftc8inx 5637 43 % % NN cord-010092-uftc8inx 5637 44 and and CC cord-010092-uftc8inx 5637 45 149 149 CD cord-010092-uftc8inx 5637 46 ( ( -LRB- cord-010092-uftc8inx 5637 47 25 25 CD cord-010092-uftc8inx 5637 48 % % NN cord-010092-uftc8inx 5637 49 ) ) -RRB- cord-010092-uftc8inx 5637 50 did do VBD cord-010092-uftc8inx 5637 51 not not RB cord-010092-uftc8inx 5637 52 take take VB cord-010092-uftc8inx 5637 53 any any DT cord-010092-uftc8inx 5637 54 . . . cord-010092-uftc8inx 5638 1 Gastrointestinal gastrointestinal JJ cord-010092-uftc8inx 5638 2 upset upset NN cord-010092-uftc8inx 5638 3 was be VBD cord-010092-uftc8inx 5638 4 reported report VBN cord-010092-uftc8inx 5638 5 in in IN cord-010092-uftc8inx 5638 6 113 113 CD cord-010092-uftc8inx 5638 7 ( ( -LRB- cord-010092-uftc8inx 5638 8 25 25 CD cord-010092-uftc8inx 5638 9 % % NN cord-010092-uftc8inx 5638 10 ) ) -RRB- cord-010092-uftc8inx 5638 11 donors donor NNS cord-010092-uftc8inx 5638 12 and and CC cord-010092-uftc8inx 5638 13 constipation constipation NN cord-010092-uftc8inx 5638 14 seen see VBN cord-010092-uftc8inx 5638 15 in in IN cord-010092-uftc8inx 5638 16 193 193 CD cord-010092-uftc8inx 5638 17 ( ( -LRB- cord-010092-uftc8inx 5638 18 43 43 CD cord-010092-uftc8inx 5638 19 % % NN cord-010092-uftc8inx 5638 20 ) ) -RRB- cord-010092-uftc8inx 5638 21 among among IN cord-010092-uftc8inx 5638 22 those those DT cord-010092-uftc8inx 5638 23 who who WP cord-010092-uftc8inx 5638 24 took take VBD cord-010092-uftc8inx 5638 25 at at IN cord-010092-uftc8inx 5638 26 least least JJS cord-010092-uftc8inx 5638 27 some some DT cord-010092-uftc8inx 5638 28 of of IN cord-010092-uftc8inx 5638 29 the the DT cord-010092-uftc8inx 5638 30 iron iron NN cord-010092-uftc8inx 5638 31 supplementation supplementation NN cord-010092-uftc8inx 5638 32 . . . cord-010092-uftc8inx 5639 1 Most Most JJS cord-010092-uftc8inx 5639 2 respondents respondent NNS cord-010092-uftc8inx 5639 3 answered answer VBD cord-010092-uftc8inx 5639 4 correctly correctly RB cord-010092-uftc8inx 5639 5 to to IN cord-010092-uftc8inx 5639 6 the the DT cord-010092-uftc8inx 5639 7 questions question NNS cord-010092-uftc8inx 5639 8 on on IN cord-010092-uftc8inx 5639 9 the the DT cord-010092-uftc8inx 5639 10 knowledge knowledge NN cord-010092-uftc8inx 5639 11 on on IN cord-010092-uftc8inx 5639 12 iron iron NN cord-010092-uftc8inx 5639 13 store store NN cord-010092-uftc8inx 5639 14 and and CC cord-010092-uftc8inx 5639 15 absorption absorption NN cord-010092-uftc8inx 5639 16 . . . cord-010092-uftc8inx 5640 1 When when WRB cord-010092-uftc8inx 5640 2 comparing compare VBG cord-010092-uftc8inx 5640 3 those those DT cord-010092-uftc8inx 5640 4 with with IN cord-010092-uftc8inx 5640 5 better well JJR cord-010092-uftc8inx 5640 6 compliance compliance NN cord-010092-uftc8inx 5640 7 ( ( -LRB- cord-010092-uftc8inx 5640 8 took take VBD cord-010092-uftc8inx 5640 9 more more JJR cord-010092-uftc8inx 5640 10 than than IN cord-010092-uftc8inx 5640 11 50 50 CD cord-010092-uftc8inx 5640 12 % % NN cord-010092-uftc8inx 5640 13 ) ) -RRB- cord-010092-uftc8inx 5640 14 to to IN cord-010092-uftc8inx 5640 15 those those DT cord-010092-uftc8inx 5640 16 who who WP cord-010092-uftc8inx 5640 17 did do VBD cord-010092-uftc8inx 5640 18 not not RB cord-010092-uftc8inx 5640 19 ( ( -LRB- cord-010092-uftc8inx 5640 20 took take VBD cord-010092-uftc8inx 5640 21 less less JJR cord-010092-uftc8inx 5640 22 than than IN cord-010092-uftc8inx 5640 23 50 50 CD cord-010092-uftc8inx 5640 24 % % NN cord-010092-uftc8inx 5640 25 ) ) -RRB- cord-010092-uftc8inx 5640 26 , , , cord-010092-uftc8inx 5640 27 significantly significantly RB cord-010092-uftc8inx 5640 28 more more JJR cord-010092-uftc8inx 5640 29 donors donor NNS cord-010092-uftc8inx 5640 30 in in IN cord-010092-uftc8inx 5640 31 the the DT cord-010092-uftc8inx 5640 32 former former JJ cord-010092-uftc8inx 5640 33 knew know VBD cord-010092-uftc8inx 5640 34 vitamin vitamin NN cord-010092-uftc8inx 5640 35 C C NNP cord-010092-uftc8inx 5640 36 could could MD cord-010092-uftc8inx 5640 37 enhance enhance VB cord-010092-uftc8inx 5640 38 iron iron NN cord-010092-uftc8inx 5640 39 absorption absorption NN cord-010092-uftc8inx 5640 40 ( ( -LRB- cord-010092-uftc8inx 5640 41 P p NN cord-010092-uftc8inx 5640 42 < < XX cord-010092-uftc8inx 5640 43 0.05 0.05 CD cord-010092-uftc8inx 5640 44 ) ) -RRB- cord-010092-uftc8inx 5640 45 . . . cord-010092-uftc8inx 5641 1 On on IN cord-010092-uftc8inx 5641 2 the the DT cord-010092-uftc8inx 5641 3 other other JJ cord-010092-uftc8inx 5641 4 hand hand NN cord-010092-uftc8inx 5641 5 , , , cord-010092-uftc8inx 5641 6 no no DT cord-010092-uftc8inx 5641 7 difference difference NN cord-010092-uftc8inx 5641 8 was be VBD cord-010092-uftc8inx 5641 9 seen see VBN cord-010092-uftc8inx 5641 10 when when WRB cord-010092-uftc8inx 5641 11 they -PRON- PRP cord-010092-uftc8inx 5641 12 were be VBD cord-010092-uftc8inx 5641 13 asked ask VBN cord-010092-uftc8inx 5641 14 if if IN cord-010092-uftc8inx 5641 15 1 1 CD cord-010092-uftc8inx 5641 16 ) ) -RRB- cord-010092-uftc8inx 5641 17 Iron iron NN cord-010092-uftc8inx 5641 18 can can MD cord-010092-uftc8inx 5641 19 only only RB cord-010092-uftc8inx 5641 20 be be VB cord-010092-uftc8inx 5641 21 absorbed absorb VBN cord-010092-uftc8inx 5641 22 from from IN cord-010092-uftc8inx 5641 23 meat meat NN cord-010092-uftc8inx 5641 24 ; ; : cord-010092-uftc8inx 5641 25 2 2 LS cord-010092-uftc8inx 5641 26 ) ) -RRB- cord-010092-uftc8inx 5641 27 Tea tea NN cord-010092-uftc8inx 5641 28 and and CC cord-010092-uftc8inx 5641 29 coffee coffee NN cord-010092-uftc8inx 5641 30 consumed consume VBN cord-010092-uftc8inx 5641 31 during during IN cord-010092-uftc8inx 5641 32 meal meal NN cord-010092-uftc8inx 5641 33 can can MD cord-010092-uftc8inx 5641 34 enhance enhance VB cord-010092-uftc8inx 5641 35 iron iron NN cord-010092-uftc8inx 5641 36 absorption absorption NN cord-010092-uftc8inx 5641 37 ; ; : cord-010092-uftc8inx 5641 38 3 3 LS cord-010092-uftc8inx 5641 39 ) ) -RRB- cord-010092-uftc8inx 5641 40 Everyone everyone NN cord-010092-uftc8inx 5641 41 can can MD cord-010092-uftc8inx 5641 42 take take VB cord-010092-uftc8inx 5641 43 iron iron NN cord-010092-uftc8inx 5641 44 supplementation supplementation NN cord-010092-uftc8inx 5641 45 on on IN cord-010092-uftc8inx 5641 46 their -PRON- PRP$ cord-010092-uftc8inx 5641 47 own own JJ cord-010092-uftc8inx 5641 48 ; ; : cord-010092-uftc8inx 5641 49 and and CC cord-010092-uftc8inx 5641 50 4 4 LS cord-010092-uftc8inx 5641 51 ) ) -RRB- cord-010092-uftc8inx 5641 52 Iron iron NN cord-010092-uftc8inx 5641 53 store store NN cord-010092-uftc8inx 5641 54 in in IN cord-010092-uftc8inx 5641 55 male male NN cord-010092-uftc8inx 5641 56 is be VBZ cord-010092-uftc8inx 5641 57 always always RB cord-010092-uftc8inx 5641 58 more more JJR cord-010092-uftc8inx 5641 59 than than IN cord-010092-uftc8inx 5641 60 female female JJ cord-010092-uftc8inx 5641 61 . . . cord-010092-uftc8inx 5642 1 Summary Summary NNP cord-010092-uftc8inx 5642 2 / / SYM cord-010092-uftc8inx 5642 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 5642 4 : : : cord-010092-uftc8inx 5643 1 The the DT cord-010092-uftc8inx 5643 2 results result NNS cord-010092-uftc8inx 5643 3 suggested suggest VBD cord-010092-uftc8inx 5643 4 that that IN cord-010092-uftc8inx 5643 5 there there EX cord-010092-uftc8inx 5643 6 is be VBZ cord-010092-uftc8inx 5643 7 definitely definitely RB cord-010092-uftc8inx 5643 8 more more JJR cord-010092-uftc8inx 5643 9 room room NN cord-010092-uftc8inx 5643 10 to to TO cord-010092-uftc8inx 5643 11 enhance enhance VB cord-010092-uftc8inx 5643 12 the the DT cord-010092-uftc8inx 5643 13 blood blood NN cord-010092-uftc8inx 5643 14 donors donor NNS cord-010092-uftc8inx 5643 15 ' ' POS cord-010092-uftc8inx 5643 16 knowledge knowledge NN cord-010092-uftc8inx 5643 17 on on IN cord-010092-uftc8inx 5643 18 iron iron NN cord-010092-uftc8inx 5643 19 store store NN cord-010092-uftc8inx 5643 20 and and CC cord-010092-uftc8inx 5643 21 absorption absorption NN cord-010092-uftc8inx 5643 22 in in IN cord-010092-uftc8inx 5643 23 order order NN cord-010092-uftc8inx 5643 24 to to TO cord-010092-uftc8inx 5643 25 improve improve VB cord-010092-uftc8inx 5643 26 the the DT cord-010092-uftc8inx 5643 27 effectiveness effectiveness NN cord-010092-uftc8inx 5643 28 of of IN cord-010092-uftc8inx 5643 29 iron iron NN cord-010092-uftc8inx 5643 30 supplementation supplementation NN cord-010092-uftc8inx 5643 31 programme programme NN cord-010092-uftc8inx 5643 32 . . . cord-010092-uftc8inx 5644 1 Besides besides RB cord-010092-uftc8inx 5644 2 , , , cord-010092-uftc8inx 5644 3 the the DT cord-010092-uftc8inx 5644 4 side side NN cord-010092-uftc8inx 5644 5 effects effect NNS cord-010092-uftc8inx 5644 6 reported report VBN cord-010092-uftc8inx 5644 7 by by IN cord-010092-uftc8inx 5644 8 the the DT cord-010092-uftc8inx 5644 9 donors donor NNS cord-010092-uftc8inx 5644 10 could could MD cord-010092-uftc8inx 5644 11 be be VB cord-010092-uftc8inx 5644 12 an an DT cord-010092-uftc8inx 5644 13 important important JJ cord-010092-uftc8inx 5644 14 limiting limit VBG cord-010092-uftc8inx 5644 15 factor factor NN cord-010092-uftc8inx 5644 16 that that WDT cord-010092-uftc8inx 5644 17 better well JJR cord-010092-uftc8inx 5644 18 alternatives alternative NNS cord-010092-uftc8inx 5644 19 should should MD cord-010092-uftc8inx 5644 20 be be VB cord-010092-uftc8inx 5644 21 explored explore VBN cord-010092-uftc8inx 5644 22 and and CC cord-010092-uftc8inx 5644 23 considered consider VBN cord-010092-uftc8inx 5644 24 . . . cord-010092-uftc8inx 5645 1 Background background NN cord-010092-uftc8inx 5645 2 : : : cord-010092-uftc8inx 5646 1 Vasovagal vasovagal JJ cord-010092-uftc8inx 5646 2 reactions reaction NNS cord-010092-uftc8inx 5646 3 ( ( -LRB- cord-010092-uftc8inx 5646 4 VVR vvr NN cord-010092-uftc8inx 5646 5 ) ) -RRB- cord-010092-uftc8inx 5646 6 are be VBP cord-010092-uftc8inx 5646 7 a a DT cord-010092-uftc8inx 5646 8 well well RB cord-010092-uftc8inx 5646 9 - - HYPH cord-010092-uftc8inx 5646 10 established establish VBN cord-010092-uftc8inx 5646 11 deterrent deterrent NN cord-010092-uftc8inx 5646 12 to to IN cord-010092-uftc8inx 5646 13 donor donor NN cord-010092-uftc8inx 5646 14 return return NN cord-010092-uftc8inx 5646 15 . . . cord-010092-uftc8inx 5647 1 However however RB cord-010092-uftc8inx 5647 2 , , , cord-010092-uftc8inx 5647 3 the the DT cord-010092-uftc8inx 5647 4 correspondence correspondence NN cord-010092-uftc8inx 5647 5 between between IN cord-010092-uftc8inx 5647 6 VVR vvr NN cord-010092-uftc8inx 5647 7 experience experience NN cord-010092-uftc8inx 5647 8 and and CC cord-010092-uftc8inx 5647 9 donor donor NN cord-010092-uftc8inx 5647 10 lapse lapse NN cord-010092-uftc8inx 5647 11 is be VBZ cord-010092-uftc8inx 5647 12 not not RB cord-010092-uftc8inx 5647 13 perfect perfect JJ cord-010092-uftc8inx 5647 14 . . . cord-010092-uftc8inx 5648 1 In in IN cord-010092-uftc8inx 5648 2 Australia Australia NNP cord-010092-uftc8inx 5648 3 , , , cord-010092-uftc8inx 5648 4 for for IN cord-010092-uftc8inx 5648 5 example example NN cord-010092-uftc8inx 5648 6 , , , cord-010092-uftc8inx 5648 7 VVRs vvr NNS cord-010092-uftc8inx 5648 8 only only RB cord-010092-uftc8inx 5648 9 reduce reduce VB cord-010092-uftc8inx 5648 10 two two CD cord-010092-uftc8inx 5648 11 - - HYPH cord-010092-uftc8inx 5648 12 year year NN cord-010092-uftc8inx 5648 13 return return NN cord-010092-uftc8inx 5648 14 rates rate NNS cord-010092-uftc8inx 5648 15 by by IN cord-010092-uftc8inx 5648 16 27 27 CD cord-010092-uftc8inx 5648 17 % % NN cord-010092-uftc8inx 5648 18 for for IN cord-010092-uftc8inx 5648 19 whole whole JJ cord-010092-uftc8inx 5648 20 blood blood NN cord-010092-uftc8inx 5648 21 donors donor NNS cord-010092-uftc8inx 5648 22 and and CC cord-010092-uftc8inx 5648 23 22 22 CD cord-010092-uftc8inx 5648 24 % % NN cord-010092-uftc8inx 5648 25 for for IN cord-010092-uftc8inx 5648 26 plasma plasma NN cord-010092-uftc8inx 5648 27 donors donor NNS cord-010092-uftc8inx 5648 28 . . . cord-010092-uftc8inx 5649 1 The the DT cord-010092-uftc8inx 5649 2 elements element NNS cord-010092-uftc8inx 5649 3 of of IN cord-010092-uftc8inx 5649 4 a a DT cord-010092-uftc8inx 5649 5 VVR vvr NN cord-010092-uftc8inx 5649 6 and and CC cord-010092-uftc8inx 5649 7 the the DT cord-010092-uftc8inx 5649 8 donor donor NN cord-010092-uftc8inx 5649 9 's 's POS cord-010092-uftc8inx 5649 10 interpretation interpretation NN cord-010092-uftc8inx 5649 11 of of IN cord-010092-uftc8inx 5649 12 this this DT cord-010092-uftc8inx 5649 13 event event NN cord-010092-uftc8inx 5649 14 that that WDT cord-010092-uftc8inx 5649 15 protect protect VBP cord-010092-uftc8inx 5649 16 against against IN cord-010092-uftc8inx 5649 17 or or CC cord-010092-uftc8inx 5649 18 encourage encourage VB cord-010092-uftc8inx 5649 19 lapse lapse NN cord-010092-uftc8inx 5649 20 have have VBP cord-010092-uftc8inx 5649 21 not not RB cord-010092-uftc8inx 5649 22 yet yet RB cord-010092-uftc8inx 5649 23 been be VBN cord-010092-uftc8inx 5649 24 identified identify VBN cord-010092-uftc8inx 5649 25 . . . cord-010092-uftc8inx 5650 1 Aims aim VBZ cord-010092-uftc8inx 5650 2 : : : cord-010092-uftc8inx 5651 1 In in IN cord-010092-uftc8inx 5651 2 this this DT cord-010092-uftc8inx 5651 3 study study NN cord-010092-uftc8inx 5651 4 we -PRON- PRP cord-010092-uftc8inx 5651 5 explored explore VBD cord-010092-uftc8inx 5651 6 the the DT cord-010092-uftc8inx 5651 7 views view NNS cord-010092-uftc8inx 5651 8 of of IN cord-010092-uftc8inx 5651 9 donors donor NNS cord-010092-uftc8inx 5651 10 on on IN cord-010092-uftc8inx 5651 11 donating donate VBG cord-010092-uftc8inx 5651 12 following follow VBG cord-010092-uftc8inx 5651 13 a a DT cord-010092-uftc8inx 5651 14 VVR vvr NN cord-010092-uftc8inx 5651 15 , , , cord-010092-uftc8inx 5651 16 with with IN cord-010092-uftc8inx 5651 17 a a DT cord-010092-uftc8inx 5651 18 particular particular JJ cord-010092-uftc8inx 5651 19 interest interest NN cord-010092-uftc8inx 5651 20 in in IN cord-010092-uftc8inx 5651 21 their -PRON- PRP$ cord-010092-uftc8inx 5651 22 emotional emotional JJ cord-010092-uftc8inx 5651 23 reaction reaction NN cord-010092-uftc8inx 5651 24 to to IN cord-010092-uftc8inx 5651 25 the the DT cord-010092-uftc8inx 5651 26 VVR vvr NN cord-010092-uftc8inx 5651 27 , , , cord-010092-uftc8inx 5651 28 their -PRON- PRP$ cord-010092-uftc8inx 5651 29 understanding understanding NN cord-010092-uftc8inx 5651 30 of of IN cord-010092-uftc8inx 5651 31 what what WP cord-010092-uftc8inx 5651 32 caused cause VBD cord-010092-uftc8inx 5651 33 the the DT cord-010092-uftc8inx 5651 34 reaction reaction NN cord-010092-uftc8inx 5651 35 , , , cord-010092-uftc8inx 5651 36 and and CC cord-010092-uftc8inx 5651 37 their -PRON- PRP$ cord-010092-uftc8inx 5651 38 intentions intention NNS cord-010092-uftc8inx 5651 39 to to TO cord-010092-uftc8inx 5651 40 return return VB cord-010092-uftc8inx 5651 41 . . . cord-010092-uftc8inx 5652 1 Methods method NNS cord-010092-uftc8inx 5652 2 : : : cord-010092-uftc8inx 5652 3 Semi semi JJ cord-010092-uftc8inx 5652 4 - - JJ cord-010092-uftc8inx 5652 5 structured structured JJ cord-010092-uftc8inx 5652 6 telephone telephone NN cord-010092-uftc8inx 5652 7 interviews interview NNS cord-010092-uftc8inx 5652 8 were be VBD cord-010092-uftc8inx 5652 9 conducted conduct VBN cord-010092-uftc8inx 5652 10 with with IN cord-010092-uftc8inx 5652 11 36 36 CD cord-010092-uftc8inx 5652 12 whole whole JJ cord-010092-uftc8inx 5652 13 blood blood NN cord-010092-uftc8inx 5652 14 and and CC cord-010092-uftc8inx 5652 15 plasma plasma NN cord-010092-uftc8inx 5652 16 donors donor NNS cord-010092-uftc8inx 5652 17 who who WP cord-010092-uftc8inx 5652 18 had have VBD cord-010092-uftc8inx 5652 19 a a DT cord-010092-uftc8inx 5652 20 recent recent JJ cord-010092-uftc8inx 5652 21 VVR vvr NN cord-010092-uftc8inx 5652 22 experience experience NN cord-010092-uftc8inx 5652 23 . . . cord-010092-uftc8inx 5653 1 Data datum NNS cord-010092-uftc8inx 5653 2 were be VBD cord-010092-uftc8inx 5653 3 analysed analyse VBN cord-010092-uftc8inx 5653 4 using use VBG cord-010092-uftc8inx 5653 5 the the DT cord-010092-uftc8inx 5653 6 Framework Framework NNP cord-010092-uftc8inx 5653 7 approach approach NN cord-010092-uftc8inx 5653 8 . . . cord-010092-uftc8inx 5654 1 Results result NNS cord-010092-uftc8inx 5654 2 : : : cord-010092-uftc8inx 5655 1 Donors donor NNS cord-010092-uftc8inx 5655 2 are be VBP cord-010092-uftc8inx 5655 3 generally generally RB cord-010092-uftc8inx 5655 4 motivated motivated JJ cord-010092-uftc8inx 5655 5 to to TO cord-010092-uftc8inx 5655 6 give give VB cord-010092-uftc8inx 5655 7 blood blood NN cord-010092-uftc8inx 5655 8 to to TO cord-010092-uftc8inx 5655 9 help help VB cord-010092-uftc8inx 5655 10 others other NNS cord-010092-uftc8inx 5655 11 and and CC cord-010092-uftc8inx 5655 12 to to TO cord-010092-uftc8inx 5655 13 positively positively RB cord-010092-uftc8inx 5655 14 impact impact VB cord-010092-uftc8inx 5655 15 on on IN cord-010092-uftc8inx 5655 16 those those DT cord-010092-uftc8inx 5655 17 in in IN cord-010092-uftc8inx 5655 18 their -PRON- PRP$ cord-010092-uftc8inx 5655 19 communities community NNS cord-010092-uftc8inx 5655 20 . . . cord-010092-uftc8inx 5656 1 They -PRON- PRP cord-010092-uftc8inx 5656 2 anticipate anticipate VBP cord-010092-uftc8inx 5656 3 feeling feel VBG cord-010092-uftc8inx 5656 4 good good JJ cord-010092-uftc8inx 5656 5 after after IN cord-010092-uftc8inx 5656 6 their -PRON- PRP$ cord-010092-uftc8inx 5656 7 donation donation NN cord-010092-uftc8inx 5656 8 but but CC cord-010092-uftc8inx 5656 9 in in IN cord-010092-uftc8inx 5656 10 contrast contrast NN cord-010092-uftc8inx 5656 11 , , , cord-010092-uftc8inx 5656 12 for for IN cord-010092-uftc8inx 5656 13 many many JJ cord-010092-uftc8inx 5656 14 , , , cord-010092-uftc8inx 5656 15 a a DT cord-010092-uftc8inx 5656 16 VVR vvr NN cord-010092-uftc8inx 5656 17 leaves leave VBZ cord-010092-uftc8inx 5656 18 them -PRON- PRP cord-010092-uftc8inx 5656 19 feeling feel VBG cord-010092-uftc8inx 5656 20 anxious anxious JJ cord-010092-uftc8inx 5656 21 , , , cord-010092-uftc8inx 5656 22 embarrassed embarrassed JJ cord-010092-uftc8inx 5656 23 , , , cord-010092-uftc8inx 5656 24 and and CC cord-010092-uftc8inx 5656 25 disappointed disappointed JJ cord-010092-uftc8inx 5656 26 . . . cord-010092-uftc8inx 5657 1 For for IN cord-010092-uftc8inx 5657 2 donors donor NNS cord-010092-uftc8inx 5657 3 , , , cord-010092-uftc8inx 5657 4 the the DT cord-010092-uftc8inx 5657 5 experience experience NN cord-010092-uftc8inx 5657 6 of of IN cord-010092-uftc8inx 5657 7 a a DT cord-010092-uftc8inx 5657 8 VVR vvr NN cord-010092-uftc8inx 5657 9 negatively negatively RB cord-010092-uftc8inx 5657 10 influences influence VBZ cord-010092-uftc8inx 5657 11 their -PRON- PRP$ cord-010092-uftc8inx 5657 12 perceived perceive VBN cord-010092-uftc8inx 5657 13 ability ability NN cord-010092-uftc8inx 5657 14 to to TO cord-010092-uftc8inx 5657 15 donate donate VB cord-010092-uftc8inx 5657 16 successfully successfully RB cord-010092-uftc8inx 5657 17 , , , cord-010092-uftc8inx 5657 18 and and CC cord-010092-uftc8inx 5657 19 many many JJ cord-010092-uftc8inx 5657 20 fear fear VBP cord-010092-uftc8inx 5657 21 it -PRON- PRP cord-010092-uftc8inx 5657 22 will will MD cord-010092-uftc8inx 5657 23 happen happen VB cord-010092-uftc8inx 5657 24 again again RB cord-010092-uftc8inx 5657 25 . . . cord-010092-uftc8inx 5658 1 However however RB cord-010092-uftc8inx 5658 2 , , , cord-010092-uftc8inx 5658 3 this this DT cord-010092-uftc8inx 5658 4 effect effect NN cord-010092-uftc8inx 5658 5 appears appear VBZ cord-010092-uftc8inx 5658 6 minimised minimise VBN cord-010092-uftc8inx 5658 7 among among IN cord-010092-uftc8inx 5658 8 donors donor NNS cord-010092-uftc8inx 5658 9 who who WP cord-010092-uftc8inx 5658 10 at at IN cord-010092-uftc8inx 5658 11 least least JJS cord-010092-uftc8inx 5658 12 partially partially RB cord-010092-uftc8inx 5658 13 attributed attribute VBN cord-010092-uftc8inx 5658 14 their -PRON- PRP$ cord-010092-uftc8inx 5658 15 reaction reaction NN cord-010092-uftc8inx 5658 16 to to IN cord-010092-uftc8inx 5658 17 their -PRON- PRP$ cord-010092-uftc8inx 5658 18 own own JJ cord-010092-uftc8inx 5658 19 behaviour behaviour NN cord-010092-uftc8inx 5658 20 , , , cord-010092-uftc8inx 5658 21 such such JJ cord-010092-uftc8inx 5658 22 as as IN cord-010092-uftc8inx 5658 23 poor poor JJ cord-010092-uftc8inx 5658 24 hydration hydration NN cord-010092-uftc8inx 5658 25 . . . cord-010092-uftc8inx 5659 1 For for IN cord-010092-uftc8inx 5659 2 donors donor NNS cord-010092-uftc8inx 5659 3 already already RB cord-010092-uftc8inx 5659 4 juggling juggle VBG cord-010092-uftc8inx 5659 5 multiple multiple JJ cord-010092-uftc8inx 5659 6 demands demand NNS cord-010092-uftc8inx 5659 7 , , , cord-010092-uftc8inx 5659 8 a a DT cord-010092-uftc8inx 5659 9 VVR vvr NN cord-010092-uftc8inx 5659 10 may may MD cord-010092-uftc8inx 5659 11 tip tip VB cord-010092-uftc8inx 5659 12 the the DT cord-010092-uftc8inx 5659 13 balance balance NN cord-010092-uftc8inx 5659 14 with with IN cord-010092-uftc8inx 5659 15 donating donate VBG cord-010092-uftc8inx 5659 16 becoming become VBG cord-010092-uftc8inx 5659 17 too too RB cord-010092-uftc8inx 5659 18 much much JJ cord-010092-uftc8inx 5659 19 of of IN cord-010092-uftc8inx 5659 20 an an DT cord-010092-uftc8inx 5659 21 effort effort NN cord-010092-uftc8inx 5659 22 and and CC cord-010092-uftc8inx 5659 23 perceived perceive VBN cord-010092-uftc8inx 5659 24 risk risk NN cord-010092-uftc8inx 5659 25 . . . cord-010092-uftc8inx 5660 1 However however RB cord-010092-uftc8inx 5660 2 , , , cord-010092-uftc8inx 5660 3 donors donor NNS cord-010092-uftc8inx 5660 4 appeared appear VBD cord-010092-uftc8inx 5660 5 more more RBR cord-010092-uftc8inx 5660 6 confident confident JJ cord-010092-uftc8inx 5660 7 to to TO cord-010092-uftc8inx 5660 8 return return VB cord-010092-uftc8inx 5660 9 if if IN cord-010092-uftc8inx 5660 10 they -PRON- PRP cord-010092-uftc8inx 5660 11 felt feel VBD cord-010092-uftc8inx 5660 12 supported support VBN cord-010092-uftc8inx 5660 13 by by IN cord-010092-uftc8inx 5660 14 staff staff NN cord-010092-uftc8inx 5660 15 or or CC cord-010092-uftc8inx 5660 16 if if IN cord-010092-uftc8inx 5660 17 they -PRON- PRP cord-010092-uftc8inx 5660 18 could could MD cord-010092-uftc8inx 5660 19 donate donate VB cord-010092-uftc8inx 5660 20 with with IN cord-010092-uftc8inx 5660 21 family family NN cord-010092-uftc8inx 5660 22 or or CC cord-010092-uftc8inx 5660 23 friends friend NNS cord-010092-uftc8inx 5660 24 . . . cord-010092-uftc8inx 5661 1 Summary Summary NNP cord-010092-uftc8inx 5661 2 / / SYM cord-010092-uftc8inx 5661 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 5661 4 : : : cord-010092-uftc8inx 5662 1 This this DT cord-010092-uftc8inx 5662 2 study study NN cord-010092-uftc8inx 5662 3 provides provide VBZ cord-010092-uftc8inx 5662 4 valuable valuable JJ cord-010092-uftc8inx 5662 5 insight insight NN cord-010092-uftc8inx 5662 6 into into IN cord-010092-uftc8inx 5662 7 the the DT cord-010092-uftc8inx 5662 8 VVR vvr NN cord-010092-uftc8inx 5662 9 experience experience NN cord-010092-uftc8inx 5662 10 , , , cord-010092-uftc8inx 5662 11 which which WDT cord-010092-uftc8inx 5662 12 will will MD cord-010092-uftc8inx 5662 13 aid aid VB cord-010092-uftc8inx 5662 14 in in IN cord-010092-uftc8inx 5662 15 the the DT cord-010092-uftc8inx 5662 16 improvement improvement NN cord-010092-uftc8inx 5662 17 of of IN cord-010092-uftc8inx 5662 18 donor donor NN cord-010092-uftc8inx 5662 19 safety safety NN cord-010092-uftc8inx 5662 20 and and CC cord-010092-uftc8inx 5662 21 retention retention NN cord-010092-uftc8inx 5662 22 . . . cord-010092-uftc8inx 5663 1 The the DT cord-010092-uftc8inx 5663 2 findings finding NNS cord-010092-uftc8inx 5663 3 highlight highlight VBP cord-010092-uftc8inx 5663 4 the the DT cord-010092-uftc8inx 5663 5 need need NN cord-010092-uftc8inx 5663 6 to to TO cord-010092-uftc8inx 5663 7 improve improve VB cord-010092-uftc8inx 5663 8 communication communication NN cord-010092-uftc8inx 5663 9 at at IN cord-010092-uftc8inx 5663 10 the the DT cord-010092-uftc8inx 5663 11 time time NN cord-010092-uftc8inx 5663 12 of of IN cord-010092-uftc8inx 5663 13 and and CC cord-010092-uftc8inx 5663 14 following follow VBG cord-010092-uftc8inx 5663 15 a a DT cord-010092-uftc8inx 5663 16 VVR vvr NN cord-010092-uftc8inx 5663 17 , , , cord-010092-uftc8inx 5663 18 to to TO cord-010092-uftc8inx 5663 19 educate educate VB cord-010092-uftc8inx 5663 20 donors donor NNS cord-010092-uftc8inx 5663 21 on on IN cord-010092-uftc8inx 5663 22 how how WRB cord-010092-uftc8inx 5663 23 to to TO cord-010092-uftc8inx 5663 24 reduce reduce VB cord-010092-uftc8inx 5663 25 their -PRON- PRP$ cord-010092-uftc8inx 5663 26 VVR vvr NN cord-010092-uftc8inx 5663 27 risk risk NN cord-010092-uftc8inx 5663 28 , , , cord-010092-uftc8inx 5663 29 and and CC cord-010092-uftc8inx 5663 30 to to TO cord-010092-uftc8inx 5663 31 intervene intervene VB cord-010092-uftc8inx 5663 32 to to TO cord-010092-uftc8inx 5663 33 help help VB cord-010092-uftc8inx 5663 34 donors donor NNS cord-010092-uftc8inx 5663 35 maintain maintain VB cord-010092-uftc8inx 5663 36 their -PRON- PRP$ cord-010092-uftc8inx 5663 37 perceived perceive VBN cord-010092-uftc8inx 5663 38 ability ability NN cord-010092-uftc8inx 5663 39 to to TO cord-010092-uftc8inx 5663 40 give give VB cord-010092-uftc8inx 5663 41 blood blood NN cord-010092-uftc8inx 5663 42 in in IN cord-010092-uftc8inx 5663 43 order order NN cord-010092-uftc8inx 5663 44 to to TO cord-010092-uftc8inx 5663 45 maximise maximise VB cord-010092-uftc8inx 5663 46 retention retention NN cord-010092-uftc8inx 5663 47 following follow VBG cord-010092-uftc8inx 5663 48 a a DT cord-010092-uftc8inx 5663 49 VVR vvr NN cord-010092-uftc8inx 5663 50 . . . cord-010092-uftc8inx 5664 1 Background background NN cord-010092-uftc8inx 5664 2 : : : cord-010092-uftc8inx 5665 1 Frequent frequent JJ cord-010092-uftc8inx 5665 2 blood blood NN cord-010092-uftc8inx 5665 3 donation donation NN cord-010092-uftc8inx 5665 4 depletes deplete VBZ cord-010092-uftc8inx 5665 5 the the DT cord-010092-uftc8inx 5665 6 iron iron NN cord-010092-uftc8inx 5665 7 stores store NNS cord-010092-uftc8inx 5665 8 of of IN cord-010092-uftc8inx 5665 9 blood blood NN cord-010092-uftc8inx 5665 10 donors donor NNS cord-010092-uftc8inx 5665 11 . . . cord-010092-uftc8inx 5666 1 Iron iron NN cord-010092-uftc8inx 5666 2 depletion depletion NN cord-010092-uftc8inx 5666 3 might may MD cord-010092-uftc8inx 5666 4 have have VB cord-010092-uftc8inx 5666 5 negative negative JJ cord-010092-uftc8inx 5666 6 effects effect NNS cord-010092-uftc8inx 5666 7 on on IN cord-010092-uftc8inx 5666 8 the the DT cord-010092-uftc8inx 5666 9 health health NN cord-010092-uftc8inx 5666 10 of of IN cord-010092-uftc8inx 5666 11 the the DT cord-010092-uftc8inx 5666 12 general general JJ cord-010092-uftc8inx 5666 13 population population NN cord-010092-uftc8inx 5666 14 , , , cord-010092-uftc8inx 5666 15 but but CC cord-010092-uftc8inx 5666 16 its -PRON- PRP$ cord-010092-uftc8inx 5666 17 effect effect NN cord-010092-uftc8inx 5666 18 on on IN cord-010092-uftc8inx 5666 19 the the DT cord-010092-uftc8inx 5666 20 blood blood NN cord-010092-uftc8inx 5666 21 donor donor NN cord-010092-uftc8inx 5666 22 population population NN cord-010092-uftc8inx 5666 23 is be VBZ cord-010092-uftc8inx 5666 24 not not RB cord-010092-uftc8inx 5666 25 well well RB cord-010092-uftc8inx 5666 26 known known JJ cord-010092-uftc8inx 5666 27 . . . cord-010092-uftc8inx 5667 1 Aims aim VBZ cord-010092-uftc8inx 5667 2 : : : cord-010092-uftc8inx 5668 1 To to TO cord-010092-uftc8inx 5668 2 investigate investigate VB cord-010092-uftc8inx 5668 3 the the DT cord-010092-uftc8inx 5668 4 iron iron NN cord-010092-uftc8inx 5668 5 status status NN cord-010092-uftc8inx 5668 6 of of IN cord-010092-uftc8inx 5668 7 Finnish finnish JJ cord-010092-uftc8inx 5668 8 blood blood NN cord-010092-uftc8inx 5668 9 donor donor NN cord-010092-uftc8inx 5668 10 population population NN cord-010092-uftc8inx 5668 11 and and CC cord-010092-uftc8inx 5668 12 how how WRB cord-010092-uftc8inx 5668 13 it -PRON- PRP cord-010092-uftc8inx 5668 14 relates relate VBZ cord-010092-uftc8inx 5668 15 to to IN cord-010092-uftc8inx 5668 16 donor donor NN cord-010092-uftc8inx 5668 17 health health NN cord-010092-uftc8inx 5668 18 , , , cord-010092-uftc8inx 5668 19 the the DT cord-010092-uftc8inx 5668 20 Finnish Finnish NNP cord-010092-uftc8inx 5668 21 Red Red NNP cord-010092-uftc8inx 5668 22 Cross Cross NNP cord-010092-uftc8inx 5668 23 Blood Blood NNP cord-010092-uftc8inx 5668 24 Service Service NNP cord-010092-uftc8inx 5668 25 set set VBD cord-010092-uftc8inx 5668 26 up up RP cord-010092-uftc8inx 5668 27 the the DT cord-010092-uftc8inx 5668 28 FinDonor FinDonor NNP cord-010092-uftc8inx 5668 29 10,000 10,000 CD cord-010092-uftc8inx 5668 30 study study NN cord-010092-uftc8inx 5668 31 in in IN cord-010092-uftc8inx 5668 32 2015 2015 CD cord-010092-uftc8inx 5668 33 . . . cord-010092-uftc8inx 5669 1 We -PRON- PRP cord-010092-uftc8inx 5669 2 investigated investigate VBD cord-010092-uftc8inx 5669 3 whether whether IN cord-010092-uftc8inx 5669 4 there there EX cord-010092-uftc8inx 5669 5 were be VBD cord-010092-uftc8inx 5669 6 changes change NNS cord-010092-uftc8inx 5669 7 in in IN cord-010092-uftc8inx 5669 8 donors donor NNS cord-010092-uftc8inx 5669 9 ' ' POS cord-010092-uftc8inx 5669 10 selfrated selfrated JJ cord-010092-uftc8inx 5669 11 health health NN cord-010092-uftc8inx 5669 12 and and CC cord-010092-uftc8inx 5669 13 if if IN cord-010092-uftc8inx 5669 14 these these DT cord-010092-uftc8inx 5669 15 possible possible JJ cord-010092-uftc8inx 5669 16 changes change NNS cord-010092-uftc8inx 5669 17 could could MD cord-010092-uftc8inx 5669 18 be be VB cord-010092-uftc8inx 5669 19 associated associate VBN cord-010092-uftc8inx 5669 20 with with IN cord-010092-uftc8inx 5669 21 differences difference NNS cord-010092-uftc8inx 5669 22 in in IN cord-010092-uftc8inx 5669 23 iron iron NN cord-010092-uftc8inx 5669 24 biomarkers biomarker NNS cord-010092-uftc8inx 5669 25 ( ( -LRB- cord-010092-uftc8inx 5669 26 Ferritin ferritin NN cord-010092-uftc8inx 5669 27 and and CC cord-010092-uftc8inx 5669 28 soluble soluble JJ cord-010092-uftc8inx 5669 29 transferrin transferrin NN cord-010092-uftc8inx 5669 30 receptor receptor NN cord-010092-uftc8inx 5669 31 -sTfR -sTfR : cord-010092-uftc8inx 5669 32 ) ) -RRB- cord-010092-uftc8inx 5669 33 or or CC cord-010092-uftc8inx 5669 34 hemoglobin hemoglobin NN cord-010092-uftc8inx 5669 35 levels level NNS cord-010092-uftc8inx 5669 36 during during IN cord-010092-uftc8inx 5669 37 the the DT cord-010092-uftc8inx 5669 38 first first JJ cord-010092-uftc8inx 5669 39 study study NN cord-010092-uftc8inx 5669 40 visit visit NN cord-010092-uftc8inx 5669 41 . . . cord-010092-uftc8inx 5670 1 Methods method NNS cord-010092-uftc8inx 5670 2 : : : cord-010092-uftc8inx 5670 3 Participants participant NNS cord-010092-uftc8inx 5670 4 were be VBD cord-010092-uftc8inx 5670 5 recruited recruit VBN cord-010092-uftc8inx 5670 6 in in IN cord-010092-uftc8inx 5670 7 three three CD cord-010092-uftc8inx 5670 8 donation donation NN cord-010092-uftc8inx 5670 9 sites site NNS cord-010092-uftc8inx 5670 10 in in IN cord-010092-uftc8inx 5670 11 the the DT cord-010092-uftc8inx 5670 12 capital capital NN cord-010092-uftc8inx 5670 13 region region NN cord-010092-uftc8inx 5670 14 of of IN cord-010092-uftc8inx 5670 15 Finland Finland NNP cord-010092-uftc8inx 5670 16 between between IN cord-010092-uftc8inx 5670 17 May May NNP cord-010092-uftc8inx 5670 18 2015 2015 CD cord-010092-uftc8inx 5670 19 and and CC cord-010092-uftc8inx 5670 20 December December NNP cord-010092-uftc8inx 5670 21 2017 2017 CD cord-010092-uftc8inx 5670 22 . . . cord-010092-uftc8inx 5671 1 Participants participant NNS cord-010092-uftc8inx 5671 2 filled fill VBD cord-010092-uftc8inx 5671 3 out out RP cord-010092-uftc8inx 5671 4 an an DT cord-010092-uftc8inx 5671 5 electronic electronic JJ cord-010092-uftc8inx 5671 6 questionnaire questionnaire NN cord-010092-uftc8inx 5671 7 about about IN cord-010092-uftc8inx 5671 8 their -PRON- PRP$ cord-010092-uftc8inx 5671 9 health health NN cord-010092-uftc8inx 5671 10 and and CC cord-010092-uftc8inx 5671 11 lifestyle lifestyle NN cord-010092-uftc8inx 5671 12 at at IN cord-010092-uftc8inx 5671 13 the the DT cord-010092-uftc8inx 5671 14 donation donation NN cord-010092-uftc8inx 5671 15 site site NN cord-010092-uftc8inx 5671 16 during during IN cord-010092-uftc8inx 5671 17 their -PRON- PRP$ cord-010092-uftc8inx 5671 18 enrollment enrollment NN cord-010092-uftc8inx 5671 19 visit visit NN cord-010092-uftc8inx 5671 20 . . . cord-010092-uftc8inx 5672 1 Participants participant NNS cord-010092-uftc8inx 5672 2 were be VBD cord-010092-uftc8inx 5672 3 asked ask VBN cord-010092-uftc8inx 5672 4 by by IN cord-010092-uftc8inx 5672 5 letter letter NN cord-010092-uftc8inx 5672 6 to to TO cord-010092-uftc8inx 5672 7 fill fill VB cord-010092-uftc8inx 5672 8 out out RP cord-010092-uftc8inx 5672 9 the the DT cord-010092-uftc8inx 5672 10 same same JJ cord-010092-uftc8inx 5672 11 questionnaire questionnaire NN cord-010092-uftc8inx 5672 12 electronically electronically RB cord-010092-uftc8inx 5672 13 during during IN cord-010092-uftc8inx 5672 14 the the DT cord-010092-uftc8inx 5672 15 summer summer NN cord-010092-uftc8inx 5672 16 2018 2018 CD cord-010092-uftc8inx 5672 17 . . . cord-010092-uftc8inx 5673 1 We -PRON- PRP cord-010092-uftc8inx 5673 2 included include VBD cord-010092-uftc8inx 5673 3 the the DT cord-010092-uftc8inx 5673 4 1435 1435 CD cord-010092-uftc8inx 5673 5 participants participant NNS cord-010092-uftc8inx 5673 6 ( ( -LRB- cord-010092-uftc8inx 5673 7 596 596 CD cord-010092-uftc8inx 5673 8 men man NNS cord-010092-uftc8inx 5673 9 and and CC cord-010092-uftc8inx 5673 10 480 480 CD cord-010092-uftc8inx 5673 11 premenopausal premenopausal JJ cord-010092-uftc8inx 5673 12 and and CC cord-010092-uftc8inx 5673 13 359 359 CD cord-010092-uftc8inx 5673 14 postmenopausal postmenopausal JJ cord-010092-uftc8inx 5673 15 women woman NNS cord-010092-uftc8inx 5673 16 ) ) -RRB- cord-010092-uftc8inx 5673 17 who who WP cord-010092-uftc8inx 5673 18 completed complete VBD cord-010092-uftc8inx 5673 19 both both DT cord-010092-uftc8inx 5673 20 health health NN cord-010092-uftc8inx 5673 21 questionnaires questionnaire NNS cord-010092-uftc8inx 5673 22 . . . cord-010092-uftc8inx 5674 1 To to TO cord-010092-uftc8inx 5674 2 evaluate evaluate VB cord-010092-uftc8inx 5674 3 self self NN cord-010092-uftc8inx 5674 4 - - HYPH cord-010092-uftc8inx 5674 5 rated rate VBN cord-010092-uftc8inx 5674 6 health health NN cord-010092-uftc8inx 5674 7 we -PRON- PRP cord-010092-uftc8inx 5674 8 used use VBD cord-010092-uftc8inx 5674 9 the the DT cord-010092-uftc8inx 5674 10 well well RB cord-010092-uftc8inx 5674 11 - - HYPH cord-010092-uftc8inx 5674 12 validated validate VBN cord-010092-uftc8inx 5674 13 single single JJ cord-010092-uftc8inx 5674 14 question question NN cord-010092-uftc8inx 5674 15 : : : cord-010092-uftc8inx 5674 16 " " `` cord-010092-uftc8inx 5674 17 How how WRB cord-010092-uftc8inx 5674 18 would would MD cord-010092-uftc8inx 5674 19 you -PRON- PRP cord-010092-uftc8inx 5674 20 rate rate VB cord-010092-uftc8inx 5674 21 your -PRON- PRP$ cord-010092-uftc8inx 5674 22 health health NN cord-010092-uftc8inx 5674 23 in in IN cord-010092-uftc8inx 5674 24 general general JJ cord-010092-uftc8inx 5674 25 ? ? . cord-010092-uftc8inx 5674 26 " " '' cord-010092-uftc8inx 5674 27 . . . cord-010092-uftc8inx 5675 1 Participants participant NNS cord-010092-uftc8inx 5675 2 were be VBD cord-010092-uftc8inx 5675 3 able able JJ cord-010092-uftc8inx 5675 4 to to TO cord-010092-uftc8inx 5675 5 evaluate evaluate VB cord-010092-uftc8inx 5675 6 their -PRON- PRP$ cord-010092-uftc8inx 5675 7 health health NN cord-010092-uftc8inx 5675 8 status status NN cord-010092-uftc8inx 5675 9 on on IN cord-010092-uftc8inx 5675 10 a a DT cord-010092-uftc8inx 5675 11 five five CD cord-010092-uftc8inx 5675 12 - - HYPH cord-010092-uftc8inx 5675 13 point point NN cord-010092-uftc8inx 5675 14 scale scale NN cord-010092-uftc8inx 5675 15 : : : cord-010092-uftc8inx 5675 16 excellent excellent JJ cord-010092-uftc8inx 5675 17 , , , cord-010092-uftc8inx 5675 18 very very RB cord-010092-uftc8inx 5675 19 good good JJ cord-010092-uftc8inx 5675 20 , , , cord-010092-uftc8inx 5675 21 good good JJ cord-010092-uftc8inx 5675 22 , , , cord-010092-uftc8inx 5675 23 moderate moderate JJ cord-010092-uftc8inx 5675 24 , , , cord-010092-uftc8inx 5675 25 and and CC cord-010092-uftc8inx 5675 26 poor poor JJ cord-010092-uftc8inx 5675 27 . . . cord-010092-uftc8inx 5676 1 Iron iron NN cord-010092-uftc8inx 5676 2 biomarkers biomarker NNS cord-010092-uftc8inx 5676 3 and and CC cord-010092-uftc8inx 5676 4 venous venous JJ cord-010092-uftc8inx 5676 5 hemoglobin hemoglobin NN cord-010092-uftc8inx 5676 6 were be VBD cord-010092-uftc8inx 5676 7 measured measure VBN cord-010092-uftc8inx 5676 8 from from IN cord-010092-uftc8inx 5676 9 blood blood NN cord-010092-uftc8inx 5676 10 samples sample NNS cord-010092-uftc8inx 5676 11 collected collect VBN cord-010092-uftc8inx 5676 12 at at IN cord-010092-uftc8inx 5676 13 the the DT cord-010092-uftc8inx 5676 14 first first JJ cord-010092-uftc8inx 5676 15 study study NN cord-010092-uftc8inx 5676 16 visit visit NN cord-010092-uftc8inx 5676 17 . . . cord-010092-uftc8inx 5677 1 We -PRON- PRP cord-010092-uftc8inx 5677 2 first first RB cord-010092-uftc8inx 5677 3 computed compute VBD cord-010092-uftc8inx 5677 4 the the DT cord-010092-uftc8inx 5677 5 odds odd NNS cord-010092-uftc8inx 5677 6 - - : cord-010092-uftc8inx 5677 7 ratios ratio NNS cord-010092-uftc8inx 5677 8 of of IN cord-010092-uftc8inx 5677 9 reporting report VBG cord-010092-uftc8inx 5677 10 poorer poor JJR cord-010092-uftc8inx 5677 11 health health NN cord-010092-uftc8inx 5677 12 depending depend VBG cord-010092-uftc8inx 5677 13 on on IN cord-010092-uftc8inx 5677 14 demographic demographic JJ cord-010092-uftc8inx 5677 15 group group NN cord-010092-uftc8inx 5677 16 . . . cord-010092-uftc8inx 5678 1 We -PRON- PRP cord-010092-uftc8inx 5678 2 then then RB cord-010092-uftc8inx 5678 3 compared compare VBD cord-010092-uftc8inx 5678 4 iron iron NN cord-010092-uftc8inx 5678 5 biomarker biomarker NN cord-010092-uftc8inx 5678 6 and and CC cord-010092-uftc8inx 5678 7 hemoglobin hemoglobin NN cord-010092-uftc8inx 5678 8 levels level NNS cord-010092-uftc8inx 5678 9 between between IN cord-010092-uftc8inx 5678 10 donors donor NNS cord-010092-uftc8inx 5678 11 who who WP cord-010092-uftc8inx 5678 12 reported report VBD cord-010092-uftc8inx 5678 13 improved improve VBN cord-010092-uftc8inx 5678 14 , , , cord-010092-uftc8inx 5678 15 similar similar JJ cord-010092-uftc8inx 5678 16 or or CC cord-010092-uftc8inx 5678 17 poorer poor JJR cord-010092-uftc8inx 5678 18 health health NN cord-010092-uftc8inx 5678 19 rating rating NN cord-010092-uftc8inx 5678 20 . . . cord-010092-uftc8inx 5679 1 Results result NNS cord-010092-uftc8inx 5679 2 : : : cord-010092-uftc8inx 5679 3 Donors donor NNS cord-010092-uftc8inx 5679 4 who who WP cord-010092-uftc8inx 5679 5 rated rate VBD cord-010092-uftc8inx 5679 6 their -PRON- PRP$ cord-010092-uftc8inx 5679 7 health health NN cord-010092-uftc8inx 5679 8 in in IN cord-010092-uftc8inx 5679 9 the the DT cord-010092-uftc8inx 5679 10 first first JJ cord-010092-uftc8inx 5679 11 questionnaire questionnaire NN cord-010092-uftc8inx 5679 12 as as IN cord-010092-uftc8inx 5679 13 Moderate Moderate NNP cord-010092-uftc8inx 5679 14 ( ( -LRB- cord-010092-uftc8inx 5679 15 N n NN cord-010092-uftc8inx 5679 16 = = SYM cord-010092-uftc8inx 5679 17 31 31 CD cord-010092-uftc8inx 5679 18 ) ) -RRB- cord-010092-uftc8inx 5679 19 , , , cord-010092-uftc8inx 5679 20 Good good JJ cord-010092-uftc8inx 5679 21 ( ( -LRB- cord-010092-uftc8inx 5679 22 N n NN cord-010092-uftc8inx 5679 23 = = SYM cord-010092-uftc8inx 5679 24 483 483 CD cord-010092-uftc8inx 5679 25 ) ) -RRB- cord-010092-uftc8inx 5679 26 , , , cord-010092-uftc8inx 5679 27 Very very RB cord-010092-uftc8inx 5679 28 Good good JJ cord-010092-uftc8inx 5679 29 ( ( -LRB- cord-010092-uftc8inx 5679 30 N n NN cord-010092-uftc8inx 5679 31 = = SYM cord-010092-uftc8inx 5679 32 684 684 CD cord-010092-uftc8inx 5679 33 ) ) -RRB- cord-010092-uftc8inx 5679 34 or or CC cord-010092-uftc8inx 5679 35 Excellent Excellent NNP cord-010092-uftc8inx 5680 1 ( ( -LRB- cord-010092-uftc8inx 5680 2 N n NN cord-010092-uftc8inx 5680 3 = = SYM cord-010092-uftc8inx 5680 4 237 237 CD cord-010092-uftc8inx 5680 5 ) ) -RRB- cord-010092-uftc8inx 5680 6 health health NN cord-010092-uftc8inx 5680 7 tended tend VBD cord-010092-uftc8inx 5680 8 to to TO cord-010092-uftc8inx 5680 9 report report VB cord-010092-uftc8inx 5680 10 improved improve VBN cord-010092-uftc8inx 5680 11 ( ( -LRB- cord-010092-uftc8inx 5680 12 58 58 CD cord-010092-uftc8inx 5680 13 % % NN cord-010092-uftc8inx 5680 14 ) ) -RRB- cord-010092-uftc8inx 5680 15 , , , cord-010092-uftc8inx 5680 16 similar similar JJ cord-010092-uftc8inx 5680 17 ( ( -LRB- cord-010092-uftc8inx 5680 18 63 63 CD cord-010092-uftc8inx 5680 19 % % NN cord-010092-uftc8inx 5680 20 ) ) -RRB- cord-010092-uftc8inx 5680 21 , , , cord-010092-uftc8inx 5680 22 similar similar JJ cord-010092-uftc8inx 5680 23 ( ( -LRB- cord-010092-uftc8inx 5680 24 55 55 CD cord-010092-uftc8inx 5680 25 % % NN cord-010092-uftc8inx 5680 26 ) ) -RRB- cord-010092-uftc8inx 5680 27 or or CC cord-010092-uftc8inx 5680 28 poorer poor JJR cord-010092-uftc8inx 5680 29 ( ( -LRB- cord-010092-uftc8inx 5680 30 55 55 CD cord-010092-uftc8inx 5680 31 % % NN cord-010092-uftc8inx 5680 32 ) ) -RRB- cord-010092-uftc8inx 5680 33 health health NN cord-010092-uftc8inx 5680 34 ratings rating NNS cord-010092-uftc8inx 5680 35 respectively respectively RB cord-010092-uftc8inx 5680 36 in in IN cord-010092-uftc8inx 5680 37 the the DT cord-010092-uftc8inx 5680 38 second second JJ cord-010092-uftc8inx 5680 39 questionnaire questionnaire NN cord-010092-uftc8inx 5680 40 . . . cord-010092-uftc8inx 5681 1 Pre pre JJ cord-010092-uftc8inx 5681 2 - - JJ cord-010092-uftc8inx 5681 3 menopausal menopausal JJ cord-010092-uftc8inx 5681 4 women woman NNS cord-010092-uftc8inx 5681 5 reported report VBD cord-010092-uftc8inx 5681 6 their -PRON- PRP$ cord-010092-uftc8inx 5681 7 health health NN cord-010092-uftc8inx 5681 8 poorer poor JJR cord-010092-uftc8inx 5681 9 in in IN cord-010092-uftc8inx 5681 10 the the DT cord-010092-uftc8inx 5681 11 second second JJ cord-010092-uftc8inx 5681 12 questionnaire questionnaire NN cord-010092-uftc8inx 5681 13 compared compare VBN cord-010092-uftc8inx 5681 14 to to IN cord-010092-uftc8inx 5681 15 the the DT cord-010092-uftc8inx 5681 16 first first JJ cord-010092-uftc8inx 5681 17 questionnaire questionnaire NN cord-010092-uftc8inx 5681 18 more more RBR cord-010092-uftc8inx 5681 19 often often RB cord-010092-uftc8inx 5681 20 than than IN cord-010092-uftc8inx 5681 21 post post JJ cord-010092-uftc8inx 5681 22 - - JJ cord-010092-uftc8inx 5681 23 menopausal menopausal JJ cord-010092-uftc8inx 5681 24 women woman NNS cord-010092-uftc8inx 5681 25 ( ( -LRB- cord-010092-uftc8inx 5681 26 pre pre JJ cord-010092-uftc8inx 5681 27 - - JJ cord-010092-uftc8inx 5681 28 menopausal menopausal JJ cord-010092-uftc8inx 5681 29 51 51 CD cord-010092-uftc8inx 5681 30 % % NN cord-010092-uftc8inx 5681 31 , , , cord-010092-uftc8inx 5681 32 post post JJ cord-010092-uftc8inx 5681 33 - - JJ cord-010092-uftc8inx 5681 34 menopausal menopausal JJ cord-010092-uftc8inx 5681 35 women woman NNS cord-010092-uftc8inx 5681 36 38 38 CD cord-010092-uftc8inx 5681 37 % % NN cord-010092-uftc8inx 5681 38 ) ) -RRB- cord-010092-uftc8inx 5681 39 , , , cord-010092-uftc8inx 5681 40 OR or CC cord-010092-uftc8inx 5681 41 = = SYM cord-010092-uftc8inx 5681 42 1.37 1.37 CD cord-010092-uftc8inx 5681 43 95 95 CD cord-010092-uftc8inx 5681 44 % % NN cord-010092-uftc8inx 5681 45 CI CI NNP cord-010092-uftc8inx 5681 46 1.02 1.02 CD cord-010092-uftc8inx 5681 47 - - SYM cord-010092-uftc8inx 5681 48 1.85 1.85 CD cord-010092-uftc8inx 5681 49 ) ) -RRB- cord-010092-uftc8inx 5681 50 . . . cord-010092-uftc8inx 5682 1 There there EX cord-010092-uftc8inx 5682 2 were be VBD cord-010092-uftc8inx 5682 3 no no DT cord-010092-uftc8inx 5682 4 differences difference NNS cord-010092-uftc8inx 5682 5 between between IN cord-010092-uftc8inx 5682 6 other other JJ cord-010092-uftc8inx 5682 7 groups group NNS cord-010092-uftc8inx 5682 8 . . . cord-010092-uftc8inx 5683 1 There there EX cord-010092-uftc8inx 5683 2 were be VBD cord-010092-uftc8inx 5683 3 no no DT cord-010092-uftc8inx 5683 4 significant significant JJ cord-010092-uftc8inx 5683 5 differences difference NNS cord-010092-uftc8inx 5683 6 in in IN cord-010092-uftc8inx 5683 7 iron iron NN cord-010092-uftc8inx 5683 8 biomarkers biomarker NNS cord-010092-uftc8inx 5683 9 levels level NNS cord-010092-uftc8inx 5683 10 ( ( -LRB- cord-010092-uftc8inx 5683 11 ferritin ferritin NN cord-010092-uftc8inx 5683 12 and and CC cord-010092-uftc8inx 5683 13 sTfR sTfR NNP cord-010092-uftc8inx 5683 14 ) ) -RRB- cord-010092-uftc8inx 5683 15 or or CC cord-010092-uftc8inx 5683 16 hemoglobin hemoglobin NN cord-010092-uftc8inx 5683 17 levels level NNS cord-010092-uftc8inx 5683 18 between between IN cord-010092-uftc8inx 5683 19 donors donor NNS cord-010092-uftc8inx 5683 20 whose whose WP$ cord-010092-uftc8inx 5683 21 health health NN cord-010092-uftc8inx 5683 22 ratings rating NNS cord-010092-uftc8inx 5683 23 were be VBD cord-010092-uftc8inx 5683 24 improved improve VBN cord-010092-uftc8inx 5683 25 , , , cord-010092-uftc8inx 5683 26 similar similar JJ cord-010092-uftc8inx 5683 27 or or CC cord-010092-uftc8inx 5683 28 poorer poor JJR cord-010092-uftc8inx 5683 29 . . . cord-010092-uftc8inx 5684 1 Summary Summary NNP cord-010092-uftc8inx 5684 2 / / SYM cord-010092-uftc8inx 5684 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 5684 4 : : : cord-010092-uftc8inx 5685 1 In in IN cord-010092-uftc8inx 5685 2 this this DT cord-010092-uftc8inx 5685 3 cohort cohort NN cord-010092-uftc8inx 5685 4 , , , cord-010092-uftc8inx 5685 5 pre pre JJ cord-010092-uftc8inx 5685 6 - - JJ cord-010092-uftc8inx 5685 7 menopausal menopausal JJ cord-010092-uftc8inx 5685 8 women woman NNS cord-010092-uftc8inx 5685 9 rated rate VBD cord-010092-uftc8inx 5685 10 their -PRON- PRP$ cord-010092-uftc8inx 5685 11 health health NN cord-010092-uftc8inx 5685 12 poorer poor JJR cord-010092-uftc8inx 5685 13 at at IN cord-010092-uftc8inx 5685 14 the the DT cord-010092-uftc8inx 5685 15 end end NN cord-010092-uftc8inx 5685 16 than than IN cord-010092-uftc8inx 5685 17 at at IN cord-010092-uftc8inx 5685 18 the the DT cord-010092-uftc8inx 5685 19 beginning beginning NN cord-010092-uftc8inx 5685 20 of of IN cord-010092-uftc8inx 5685 21 the the DT cord-010092-uftc8inx 5685 22 study study NN cord-010092-uftc8inx 5685 23 more more RBR cord-010092-uftc8inx 5685 24 often often RB cord-010092-uftc8inx 5685 25 than than IN cord-010092-uftc8inx 5685 26 post post JJ cord-010092-uftc8inx 5685 27 - - JJ cord-010092-uftc8inx 5685 28 menopausal menopausal JJ cord-010092-uftc8inx 5685 29 women woman NNS cord-010092-uftc8inx 5685 30 . . . cord-010092-uftc8inx 5686 1 No no DT cord-010092-uftc8inx 5686 2 association association NN cord-010092-uftc8inx 5686 3 was be VBD cord-010092-uftc8inx 5686 4 found find VBN cord-010092-uftc8inx 5686 5 between between IN cord-010092-uftc8inx 5686 6 changes change NNS cord-010092-uftc8inx 5686 7 in in IN cord-010092-uftc8inx 5686 8 self self NN cord-010092-uftc8inx 5686 9 - - HYPH cord-010092-uftc8inx 5686 10 rated rate VBN cord-010092-uftc8inx 5686 11 health health NN cord-010092-uftc8inx 5686 12 and and CC cord-010092-uftc8inx 5686 13 iron iron NN cord-010092-uftc8inx 5686 14 levels level NNS cord-010092-uftc8inx 5686 15 ( ( -LRB- cord-010092-uftc8inx 5686 16 ferritin ferritin NN cord-010092-uftc8inx 5686 17 , , , cord-010092-uftc8inx 5686 18 sTfR sTfR NNP cord-010092-uftc8inx 5686 19 ) ) -RRB- cord-010092-uftc8inx 5686 20 or or CC cord-010092-uftc8inx 5686 21 hemoglobin hemoglobin NN cord-010092-uftc8inx 5686 22 levels level NNS cord-010092-uftc8inx 5686 23 . . . cord-010092-uftc8inx 5687 1 Further further JJ cord-010092-uftc8inx 5687 2 studies study NNS cord-010092-uftc8inx 5687 3 about about IN cord-010092-uftc8inx 5687 4 the the DT cord-010092-uftc8inx 5687 5 factors factor NNS cord-010092-uftc8inx 5687 6 relating relate VBG cord-010092-uftc8inx 5687 7 to to IN cord-010092-uftc8inx 5687 8 blood blood NN cord-010092-uftc8inx 5687 9 donors donor NNS cord-010092-uftc8inx 5687 10 ' ' POS cord-010092-uftc8inx 5687 11 self self NN cord-010092-uftc8inx 5687 12 - - HYPH cord-010092-uftc8inx 5687 13 rated rate VBN cord-010092-uftc8inx 5687 14 health health NN cord-010092-uftc8inx 5687 15 need need NN cord-010092-uftc8inx 5687 16 to to TO cord-010092-uftc8inx 5687 17 be be VB cord-010092-uftc8inx 5687 18 carried carry VBN cord-010092-uftc8inx 5687 19 out out RP cord-010092-uftc8inx 5687 20 . . . cord-010092-uftc8inx 5688 1 Background background NN cord-010092-uftc8inx 5688 2 : : : cord-010092-uftc8inx 5689 1 In in IN cord-010092-uftc8inx 5689 2 recent recent JJ cord-010092-uftc8inx 5689 3 years year NNS cord-010092-uftc8inx 5689 4 , , , cord-010092-uftc8inx 5689 5 the the DT cord-010092-uftc8inx 5689 6 blood blood NN cord-010092-uftc8inx 5689 7 donation donation NN cord-010092-uftc8inx 5689 8 business business NN cord-010092-uftc8inx 5689 9 has have VBZ cord-010092-uftc8inx 5689 10 made make VBN cord-010092-uftc8inx 5689 11 great great JJ cord-010092-uftc8inx 5689 12 achievements achievement NNS cord-010092-uftc8inx 5689 13 , , , cord-010092-uftc8inx 5689 14 but but CC cord-010092-uftc8inx 5689 15 it -PRON- PRP cord-010092-uftc8inx 5689 16 still still RB cord-010092-uftc8inx 5689 17 can can MD cord-010092-uftc8inx 5689 18 not not RB cord-010092-uftc8inx 5689 19 avoid avoid VB cord-010092-uftc8inx 5689 20 the the DT cord-010092-uftc8inx 5689 21 occurrence occurrence NN cord-010092-uftc8inx 5689 22 of of IN cord-010092-uftc8inx 5689 23 adverse adverse JJ cord-010092-uftc8inx 5689 24 reactions reaction NNS cord-010092-uftc8inx 5689 25 to to IN cord-010092-uftc8inx 5689 26 blood blood NN cord-010092-uftc8inx 5689 27 donation donation NN cord-010092-uftc8inx 5689 28 which which WDT cord-010092-uftc8inx 5689 29 not not RB cord-010092-uftc8inx 5689 30 only only RB cord-010092-uftc8inx 5689 31 brings bring VBZ cord-010092-uftc8inx 5689 32 certain certain JJ cord-010092-uftc8inx 5689 33 obstacles obstacle NNS cord-010092-uftc8inx 5689 34 to to IN cord-010092-uftc8inx 5689 35 the the DT cord-010092-uftc8inx 5689 36 blood blood NN cord-010092-uftc8inx 5689 37 donation donation NN cord-010092-uftc8inx 5689 38 work work NN cord-010092-uftc8inx 5689 39 , , , cord-010092-uftc8inx 5689 40 but but CC cord-010092-uftc8inx 5689 41 also also RB cord-010092-uftc8inx 5689 42 affects affect VBZ cord-010092-uftc8inx 5689 43 the the DT cord-010092-uftc8inx 5689 44 enthusiasm enthusiasm NN cord-010092-uftc8inx 5689 45 of of IN cord-010092-uftc8inx 5689 46 blood blood NN cord-010092-uftc8inx 5689 47 donors donor NNS cord-010092-uftc8inx 5689 48 . . . cord-010092-uftc8inx 5690 1 Aims aim VBZ cord-010092-uftc8inx 5690 2 : : : cord-010092-uftc8inx 5691 1 To to TO cord-010092-uftc8inx 5691 2 understood understand VBD cord-010092-uftc8inx 5691 3 the the DT cord-010092-uftc8inx 5691 4 causes cause NNS cord-010092-uftc8inx 5691 5 and and CC cord-010092-uftc8inx 5691 6 other other JJ cord-010092-uftc8inx 5691 7 relevant relevant JJ cord-010092-uftc8inx 5691 8 factors factor NNS cord-010092-uftc8inx 5691 9 of of IN cord-010092-uftc8inx 5691 10 adverse adverse JJ cord-010092-uftc8inx 5691 11 reaction reaction NN cord-010092-uftc8inx 5691 12 among among IN cord-010092-uftc8inx 5691 13 blood blood NN cord-010092-uftc8inx 5691 14 donors donor NNS cord-010092-uftc8inx 5691 15 , , , cord-010092-uftc8inx 5691 16 the the DT cord-010092-uftc8inx 5691 17 information information NN cord-010092-uftc8inx 5691 18 of of IN cord-010092-uftc8inx 5691 19 blood blood NN cord-010092-uftc8inx 5691 20 donors donor NNS cord-010092-uftc8inx 5691 21 at at IN cord-010092-uftc8inx 5691 22 Dai Dai NNP cord-010092-uftc8inx 5691 23 Autonomous Autonomous NNP cord-010092-uftc8inx 5691 24 Prefecture Prefecture NNP cord-010092-uftc8inx 5691 25 of of IN cord-010092-uftc8inx 5691 26 Xishuangbanna Xishuangbanna NNP cord-010092-uftc8inx 5691 27 were be VBD cord-010092-uftc8inx 5691 28 analyzed analyze VBN cord-010092-uftc8inx 5691 29 in in IN cord-010092-uftc8inx 5691 30 2018 2018 CD cord-010092-uftc8inx 5691 31 . . . cord-010092-uftc8inx 5692 1 Methods method NNS cord-010092-uftc8inx 5692 2 : : : cord-010092-uftc8inx 5693 1 The the DT cord-010092-uftc8inx 5693 2 data datum NNS cord-010092-uftc8inx 5693 3 of of IN cord-010092-uftc8inx 5693 4 volunteers volunteer NNS cord-010092-uftc8inx 5693 5 from from IN cord-010092-uftc8inx 5693 6 January January NNP cord-010092-uftc8inx 5693 7 to to IN cord-010092-uftc8inx 5693 8 December December NNP cord-010092-uftc8inx 5693 9 2018 2018 CD cord-010092-uftc8inx 5693 10 were be VBD cord-010092-uftc8inx 5693 11 analyzed analyze VBN cord-010092-uftc8inx 5693 12 . . . cord-010092-uftc8inx 5694 1 The the DT cord-010092-uftc8inx 5694 2 causes cause NNS cord-010092-uftc8inx 5694 3 of of IN cord-010092-uftc8inx 5694 4 adverse adverse JJ cord-010092-uftc8inx 5694 5 reactions reaction NNS cord-010092-uftc8inx 5694 6 were be VBD cord-010092-uftc8inx 5694 7 classified classify VBN cord-010092-uftc8inx 5694 8 , , , cord-010092-uftc8inx 5694 9 and and CC cord-010092-uftc8inx 5694 10 the the DT cord-010092-uftc8inx 5694 11 incidence incidence NN cord-010092-uftc8inx 5694 12 of of IN cord-010092-uftc8inx 5694 13 adverse adverse JJ cord-010092-uftc8inx 5694 14 reactions reaction NNS cord-010092-uftc8inx 5694 15 was be VBD cord-010092-uftc8inx 5694 16 compared compare VBN cord-010092-uftc8inx 5694 17 in in IN cord-010092-uftc8inx 5694 18 terms term NNS cord-010092-uftc8inx 5694 19 of of IN cord-010092-uftc8inx 5694 20 gender gender NN cord-010092-uftc8inx 5694 21 , , , cord-010092-uftc8inx 5694 22 frequency frequency NN cord-010092-uftc8inx 5694 23 , , , cord-010092-uftc8inx 5694 24 age age NN cord-010092-uftc8inx 5694 25 and and CC cord-010092-uftc8inx 5694 26 blood blood NN cord-010092-uftc8inx 5694 27 type type NN cord-010092-uftc8inx 5694 28 of of IN cord-010092-uftc8inx 5694 29 blood blood NN cord-010092-uftc8inx 5694 30 donors donor NNS cord-010092-uftc8inx 5694 31 . . . cord-010092-uftc8inx 5695 1 Results result NNS cord-010092-uftc8inx 5695 2 : : : cord-010092-uftc8inx 5696 1 There there EX cord-010092-uftc8inx 5696 2 were be VBD cord-010092-uftc8inx 5696 3 9081 9081 CD cord-010092-uftc8inx 5696 4 blood blood NN cord-010092-uftc8inx 5696 5 donors donor NNS cord-010092-uftc8inx 5696 6 in in IN cord-010092-uftc8inx 5696 7 2018 2018 CD cord-010092-uftc8inx 5696 8 , , , cord-010092-uftc8inx 5696 9 69 69 CD cord-010092-uftc8inx 5696 10 ( ( -LRB- cord-010092-uftc8inx 5696 11 0.76 0.76 CD cord-010092-uftc8inx 5696 12 % % NN cord-010092-uftc8inx 5696 13 ) ) -RRB- cord-010092-uftc8inx 5696 14 of of IN cord-010092-uftc8inx 5696 15 whom whom WP cord-010092-uftc8inx 5696 16 had have VBD cord-010092-uftc8inx 5696 17 adverse adverse JJ cord-010092-uftc8inx 5696 18 reactions reaction NNS cord-010092-uftc8inx 5696 19 and and CC cord-010092-uftc8inx 5696 20 9 9 CD cord-010092-uftc8inx 5696 21 causes cause NNS cord-010092-uftc8inx 5696 22 were be VBD cord-010092-uftc8inx 5696 23 induced induce VBN cord-010092-uftc8inx 5696 24 , , , cord-010092-uftc8inx 5696 25 among among IN cord-010092-uftc8inx 5696 26 which which WDT cord-010092-uftc8inx 5696 27 mental mental JJ cord-010092-uftc8inx 5696 28 stress stress NN cord-010092-uftc8inx 5696 29 was be VBD cord-010092-uftc8inx 5696 30 the the DT cord-010092-uftc8inx 5696 31 most most RBS cord-010092-uftc8inx 5696 32 common common JJ cord-010092-uftc8inx 5696 33 factor factor NN cord-010092-uftc8inx 5696 34 that that WDT cord-010092-uftc8inx 5696 35 accounted account VBD cord-010092-uftc8inx 5696 36 for for IN cord-010092-uftc8inx 5696 37 78.26 78.26 CD cord-010092-uftc8inx 5696 38 % % NN cord-010092-uftc8inx 5696 39 ( ( -LRB- cord-010092-uftc8inx 5696 40 54 54 CD cord-010092-uftc8inx 5696 41 cases case NNS cord-010092-uftc8inx 5696 42 ) ) -RRB- cord-010092-uftc8inx 5696 43 . . . cord-010092-uftc8inx 5697 1 There there EX cord-010092-uftc8inx 5697 2 was be VBD cord-010092-uftc8inx 5697 3 no no DT cord-010092-uftc8inx 5697 4 significant significant JJ cord-010092-uftc8inx 5697 5 difference difference NN cord-010092-uftc8inx 5697 6 in in IN cord-010092-uftc8inx 5697 7 the the DT cord-010092-uftc8inx 5697 8 incidence incidence NN cord-010092-uftc8inx 5697 9 of of IN cord-010092-uftc8inx 5697 10 adverse adverse JJ cord-010092-uftc8inx 5697 11 reactions reaction NNS cord-010092-uftc8inx 5697 12 between between IN cord-010092-uftc8inx 5697 13 men man NNS cord-010092-uftc8inx 5697 14 and and CC cord-010092-uftc8inx 5697 15 female female JJ cord-010092-uftc8inx 5697 16 ( ( -LRB- cord-010092-uftc8inx 5697 17 P p NN cord-010092-uftc8inx 5697 18 > > XX cord-010092-uftc8inx 5697 19 0.05 0.05 CD cord-010092-uftc8inx 5697 20 ) ) -RRB- cord-010092-uftc8inx 5697 21 . . . cord-010092-uftc8inx 5698 1 From from IN cord-010092-uftc8inx 5698 2 the the DT cord-010092-uftc8inx 5698 3 frequency frequency NN cord-010092-uftc8inx 5698 4 of of IN cord-010092-uftc8inx 5698 5 blood blood NN cord-010092-uftc8inx 5698 6 donation donation NN cord-010092-uftc8inx 5698 7 , , , cord-010092-uftc8inx 5698 8 the the DT cord-010092-uftc8inx 5698 9 incidence incidence NN cord-010092-uftc8inx 5698 10 in in IN cord-010092-uftc8inx 5698 11 the the DT cord-010092-uftc8inx 5698 12 first first JJ cord-010092-uftc8inx 5698 13 donor donor NN cord-010092-uftc8inx 5698 14 was be VBD cord-010092-uftc8inx 5698 15 significantly significantly RB cord-010092-uftc8inx 5698 16 higher high JJR cord-010092-uftc8inx 5698 17 than than IN cord-010092-uftc8inx 5698 18 that that DT cord-010092-uftc8inx 5698 19 in in IN cord-010092-uftc8inx 5698 20 the the DT cord-010092-uftc8inx 5698 21 second second JJ cord-010092-uftc8inx 5698 22 donor donor NN cord-010092-uftc8inx 5698 23 ( ( -LRB- cord-010092-uftc8inx 5698 24 P p NN cord-010092-uftc8inx 5698 25 < < XX cord-010092-uftc8inx 5698 26 0.01 0.01 CD cord-010092-uftc8inx 5698 27 ) ) -RRB- cord-010092-uftc8inx 5698 28 . . . cord-010092-uftc8inx 5699 1 When when WRB cord-010092-uftc8inx 5699 2 it -PRON- PRP cord-010092-uftc8inx 5699 3 comes come VBZ cord-010092-uftc8inx 5699 4 to to IN cord-010092-uftc8inx 5699 5 age age NN cord-010092-uftc8inx 5699 6 , , , cord-010092-uftc8inx 5699 7 the the DT cord-010092-uftc8inx 5699 8 incidence incidence NN cord-010092-uftc8inx 5699 9 was be VBD cord-010092-uftc8inx 5699 10 different different JJ cord-010092-uftc8inx 5699 11 and and CC cord-010092-uftc8inx 5699 12 the the DT cord-010092-uftc8inx 5699 13 18 18 CD cord-010092-uftc8inx 5699 14 - - SYM cord-010092-uftc8inx 5699 15 25 25 CD cord-010092-uftc8inx 5699 16 age age NN cord-010092-uftc8inx 5699 17 group group NN cord-010092-uftc8inx 5699 18 was be VBD cord-010092-uftc8inx 5699 19 the the DT cord-010092-uftc8inx 5699 20 highest high JJS cord-010092-uftc8inx 5699 21 ( ( -LRB- cord-010092-uftc8inx 5699 22 1.61 1.61 CD cord-010092-uftc8inx 5699 23 % % NN cord-010092-uftc8inx 5699 24 ) ) -RRB- cord-010092-uftc8inx 5699 25 . . . cord-010092-uftc8inx 5700 1 Among among IN cord-010092-uftc8inx 5700 2 different different JJ cord-010092-uftc8inx 5700 3 blood blood NN cord-010092-uftc8inx 5700 4 group group NN cord-010092-uftc8inx 5700 5 donations donation NNS cord-010092-uftc8inx 5700 6 , , , cord-010092-uftc8inx 5700 7 there there EX cord-010092-uftc8inx 5700 8 was be VBD cord-010092-uftc8inx 5700 9 no no DT cord-010092-uftc8inx 5700 10 significant significant JJ cord-010092-uftc8inx 5700 11 difference difference NN cord-010092-uftc8inx 5700 12 ( ( -LRB- cord-010092-uftc8inx 5700 13 P p NN cord-010092-uftc8inx 5700 14 > > XX cord-010092-uftc8inx 5700 15 0.05 0.05 CD cord-010092-uftc8inx 5700 16 ) ) -RRB- cord-010092-uftc8inx 5700 17 . . . cord-010092-uftc8inx 5701 1 Summary Summary NNP cord-010092-uftc8inx 5701 2 / / SYM cord-010092-uftc8inx 5701 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 5701 4 : : : cord-010092-uftc8inx 5702 1 Adverse adverse JJ cord-010092-uftc8inx 5702 2 reactions reaction NNS cord-010092-uftc8inx 5702 3 of of IN cord-010092-uftc8inx 5702 4 blood blood NN cord-010092-uftc8inx 5702 5 donation donation NN cord-010092-uftc8inx 5702 6 is be VBZ cord-010092-uftc8inx 5702 7 closely closely RB cord-010092-uftc8inx 5702 8 related related JJ cord-010092-uftc8inx 5702 9 to to IN cord-010092-uftc8inx 5702 10 the the DT cord-010092-uftc8inx 5702 11 psychological psychological JJ cord-010092-uftc8inx 5702 12 state state NN cord-010092-uftc8inx 5702 13 and and CC cord-010092-uftc8inx 5702 14 age age NN cord-010092-uftc8inx 5702 15 of of IN cord-010092-uftc8inx 5702 16 the the DT cord-010092-uftc8inx 5702 17 blood blood NN cord-010092-uftc8inx 5702 18 donors donor NNS cord-010092-uftc8inx 5702 19 . . . cord-010092-uftc8inx 5703 1 The the DT cord-010092-uftc8inx 5703 2 staff staff NN cord-010092-uftc8inx 5703 3 of of IN cord-010092-uftc8inx 5703 4 the the DT cord-010092-uftc8inx 5703 5 blood blood NN cord-010092-uftc8inx 5703 6 center center NN cord-010092-uftc8inx 5703 7 should should MD cord-010092-uftc8inx 5703 8 further further RB cord-010092-uftc8inx 5703 9 optimize optimize VB cord-010092-uftc8inx 5703 10 the the DT cord-010092-uftc8inx 5703 11 service service NN cord-010092-uftc8inx 5703 12 , , , cord-010092-uftc8inx 5703 13 strengthen strengthen VB cord-010092-uftc8inx 5703 14 the the DT cord-010092-uftc8inx 5703 15 communication communication NN cord-010092-uftc8inx 5703 16 and and CC cord-010092-uftc8inx 5703 17 publicize publicize VB cord-010092-uftc8inx 5703 18 the the DT cord-010092-uftc8inx 5703 19 knowledge knowledge NN cord-010092-uftc8inx 5703 20 of of IN cord-010092-uftc8inx 5703 21 blood blood NN cord-010092-uftc8inx 5703 22 donation donation NN cord-010092-uftc8inx 5703 23 . . . cord-010092-uftc8inx 5704 1 The the DT cord-010092-uftc8inx 5704 2 ultimate ultimate JJ cord-010092-uftc8inx 5704 3 goal goal NN cord-010092-uftc8inx 5704 4 is be VBZ cord-010092-uftc8inx 5704 5 to to TO cord-010092-uftc8inx 5704 6 increase increase VB cord-010092-uftc8inx 5704 7 the the DT cord-010092-uftc8inx 5704 8 blood blood NN cord-010092-uftc8inx 5704 9 donation donation NN cord-010092-uftc8inx 5704 10 rate rate NN cord-010092-uftc8inx 5704 11 on on IN cord-010092-uftc8inx 5704 12 the the DT cord-010092-uftc8inx 5704 13 basis basis NN cord-010092-uftc8inx 5704 14 of of IN cord-010092-uftc8inx 5704 15 reducing reduce VBG cord-010092-uftc8inx 5704 16 adverse adverse JJ cord-010092-uftc8inx 5704 17 reactions reaction NNS cord-010092-uftc8inx 5704 18 . . . cord-010092-uftc8inx 5705 1 Background background NN cord-010092-uftc8inx 5705 2 : : : cord-010092-uftc8inx 5706 1 Blood blood NN cord-010092-uftc8inx 5706 2 loss loss NN cord-010092-uftc8inx 5706 3 due due JJ cord-010092-uftc8inx 5706 4 to to IN cord-010092-uftc8inx 5706 5 repeated repeat VBN cord-010092-uftc8inx 5706 6 blood blood NN cord-010092-uftc8inx 5706 7 donation donation NN cord-010092-uftc8inx 5706 8 can can MD cord-010092-uftc8inx 5706 9 lead lead VB cord-010092-uftc8inx 5706 10 to to IN cord-010092-uftc8inx 5706 11 iron iron NN cord-010092-uftc8inx 5706 12 deficiency deficiency NN cord-010092-uftc8inx 5706 13 or or CC cord-010092-uftc8inx 5706 14 anemia anemia NN cord-010092-uftc8inx 5706 15 , , , cord-010092-uftc8inx 5706 16 but but CC cord-010092-uftc8inx 5706 17 currently currently RB cord-010092-uftc8inx 5706 18 there there EX cord-010092-uftc8inx 5706 19 is be VBZ cord-010092-uftc8inx 5706 20 no no DT cord-010092-uftc8inx 5706 21 management management NN cord-010092-uftc8inx 5706 22 plan plan NN cord-010092-uftc8inx 5706 23 for for IN cord-010092-uftc8inx 5706 24 the the DT cord-010092-uftc8inx 5706 25 prevention prevention NN cord-010092-uftc8inx 5706 26 of of IN cord-010092-uftc8inx 5706 27 iron iron NN cord-010092-uftc8inx 5706 28 deficiency deficiency NN cord-010092-uftc8inx 5706 29 in in IN cord-010092-uftc8inx 5706 30 Korean korean JJ cord-010092-uftc8inx 5706 31 blood blood NN cord-010092-uftc8inx 5706 32 donors donor NNS cord-010092-uftc8inx 5706 33 . . . cord-010092-uftc8inx 5707 1 Female female JJ cord-010092-uftc8inx 5707 2 and and CC cord-010092-uftc8inx 5707 3 male male JJ cord-010092-uftc8inx 5707 4 donors donor NNS cord-010092-uftc8inx 5707 5 are be VBP cord-010092-uftc8inx 5707 6 required require VBN cord-010092-uftc8inx 5707 7 to to TO cord-010092-uftc8inx 5707 8 wait wait VB cord-010092-uftc8inx 5707 9 at at RB cord-010092-uftc8inx 5707 10 least least JJS cord-010092-uftc8inx 5707 11 8 8 CD cord-010092-uftc8inx 5707 12 weeks week NNS cord-010092-uftc8inx 5707 13 between between IN cord-010092-uftc8inx 5707 14 blood blood NN cord-010092-uftc8inx 5707 15 donations donation NNS cord-010092-uftc8inx 5707 16 in in IN cord-010092-uftc8inx 5707 17 Korea Korea NNP cord-010092-uftc8inx 5707 18 , , , cord-010092-uftc8inx 5707 19 which which WDT cord-010092-uftc8inx 5707 20 is be VBZ cord-010092-uftc8inx 5707 21 the the DT cord-010092-uftc8inx 5707 22 shortest short JJS cord-010092-uftc8inx 5707 23 period period NN cord-010092-uftc8inx 5707 24 among among IN cord-010092-uftc8inx 5707 25 all all DT cord-010092-uftc8inx 5707 26 northeast northeast JJ cord-010092-uftc8inx 5707 27 Asian asian JJ cord-010092-uftc8inx 5707 28 countries country NNS cord-010092-uftc8inx 5707 29 . . . cord-010092-uftc8inx 5708 1 Female female JJ cord-010092-uftc8inx 5708 2 and and CC cord-010092-uftc8inx 5708 3 male male JJ cord-010092-uftc8inx 5708 4 donors donor NNS cord-010092-uftc8inx 5708 5 are be VBP cord-010092-uftc8inx 5708 6 allowed allow VBN cord-010092-uftc8inx 5708 7 to to TO cord-010092-uftc8inx 5708 8 donate donate VB cord-010092-uftc8inx 5708 9 whole whole JJ cord-010092-uftc8inx 5708 10 blood blood NN cord-010092-uftc8inx 5708 11 up up IN cord-010092-uftc8inx 5708 12 to to TO cord-010092-uftc8inx 5708 13 five five CD cord-010092-uftc8inx 5708 14 times time NNS cord-010092-uftc8inx 5708 15 per per IN cord-010092-uftc8inx 5708 16 year year NN cord-010092-uftc8inx 5708 17 and and CC cord-010092-uftc8inx 5708 18 platelets platelet NNS cord-010092-uftc8inx 5708 19 up up IN cord-010092-uftc8inx 5708 20 to to TO cord-010092-uftc8inx 5708 21 24 24 CD cord-010092-uftc8inx 5708 22 times time NNS cord-010092-uftc8inx 5708 23 per per IN cord-010092-uftc8inx 5708 24 year year NN cord-010092-uftc8inx 5708 25 ( ( -LRB- cord-010092-uftc8inx 5708 26 if if IN cord-010092-uftc8inx 5708 27 spaced space VBN cord-010092-uftc8inx 5708 28 more more JJR cord-010092-uftc8inx 5708 29 than than IN cord-010092-uftc8inx 5708 30 14 14 CD cord-010092-uftc8inx 5708 31 days day NNS cord-010092-uftc8inx 5708 32 apart apart RB cord-010092-uftc8inx 5708 33 for for IN cord-010092-uftc8inx 5708 34 the the DT cord-010092-uftc8inx 5708 35 latter latter JJ cord-010092-uftc8inx 5708 36 ) ) -RRB- cord-010092-uftc8inx 5708 37 due due IN cord-010092-uftc8inx 5708 38 to to IN cord-010092-uftc8inx 5708 39 the the DT cord-010092-uftc8inx 5708 40 chronic chronic JJ cord-010092-uftc8inx 5708 41 blood blood NN cord-010092-uftc8inx 5708 42 supply supply NN cord-010092-uftc8inx 5708 43 shortage shortage NN cord-010092-uftc8inx 5708 44 . . . cord-010092-uftc8inx 5709 1 These these DT cord-010092-uftc8inx 5709 2 facts fact NNS cord-010092-uftc8inx 5709 3 induce induce VBP cord-010092-uftc8inx 5709 4 concern concern NN cord-010092-uftc8inx 5709 5 about about IN cord-010092-uftc8inx 5709 6 the the DT cord-010092-uftc8inx 5709 7 impact impact NN cord-010092-uftc8inx 5709 8 of of IN cord-010092-uftc8inx 5709 9 blood blood NN cord-010092-uftc8inx 5709 10 donations donation NNS cord-010092-uftc8inx 5709 11 on on IN cord-010092-uftc8inx 5709 12 the the DT cord-010092-uftc8inx 5709 13 donors donor NNS cord-010092-uftc8inx 5709 14 ' ' POS cord-010092-uftc8inx 5709 15 iron iron NN cord-010092-uftc8inx 5709 16 status status NN cord-010092-uftc8inx 5709 17 . . . cord-010092-uftc8inx 5710 1 Aims aim VBZ cord-010092-uftc8inx 5710 2 : : : cord-010092-uftc8inx 5711 1 This this DT cord-010092-uftc8inx 5711 2 study study NN cord-010092-uftc8inx 5711 3 aimed aim VBD cord-010092-uftc8inx 5711 4 to to TO cord-010092-uftc8inx 5711 5 evaluate evaluate VB cord-010092-uftc8inx 5711 6 the the DT cord-010092-uftc8inx 5711 7 effect effect NN cord-010092-uftc8inx 5711 8 of of IN cord-010092-uftc8inx 5711 9 oral oral JJ cord-010092-uftc8inx 5711 10 iron iron NN cord-010092-uftc8inx 5711 11 supplementation supplementation NN cord-010092-uftc8inx 5711 12 in in IN cord-010092-uftc8inx 5711 13 repeat repeat NN cord-010092-uftc8inx 5711 14 donors donor NNS cord-010092-uftc8inx 5711 15 based base VBN cord-010092-uftc8inx 5711 16 solely solely RB cord-010092-uftc8inx 5711 17 on on IN cord-010092-uftc8inx 5711 18 donation donation NN cord-010092-uftc8inx 5711 19 history history NN cord-010092-uftc8inx 5711 20 . . . cord-010092-uftc8inx 5712 1 Methods method NNS cord-010092-uftc8inx 5712 2 : : : cord-010092-uftc8inx 5712 3 The the DT cord-010092-uftc8inx 5712 4 high high JJ cord-010092-uftc8inx 5712 5 - - HYPH cord-010092-uftc8inx 5712 6 risk risk NN cord-010092-uftc8inx 5712 7 group group NN cord-010092-uftc8inx 5712 8 included include VBD cord-010092-uftc8inx 5712 9 male male JJ cord-010092-uftc8inx 5712 10 donors donor NNS cord-010092-uftc8inx 5712 11 with with IN cord-010092-uftc8inx 5712 12 ≥4 ≥4 JJ cord-010092-uftc8inx 5712 13 whole whole JJ cord-010092-uftc8inx 5712 14 blood blood NN cord-010092-uftc8inx 5712 15 donations donation NNS cord-010092-uftc8inx 5712 16 or or CC cord-010092-uftc8inx 5712 17 16 16 CD cord-010092-uftc8inx 5712 18 plasmapheresis plasmapheresis NN cord-010092-uftc8inx 5712 19 or or CC cord-010092-uftc8inx 5712 20 plateletpheresis plateletpheresis NN cord-010092-uftc8inx 5712 21 donations donation NNS cord-010092-uftc8inx 5712 22 , , , cord-010092-uftc8inx 5712 23 and and CC cord-010092-uftc8inx 5712 24 female female JJ cord-010092-uftc8inx 5712 25 donors donor NNS cord-010092-uftc8inx 5712 26 with with IN cord-010092-uftc8inx 5712 27 ≥3 ≥3 DT cord-010092-uftc8inx 5712 28 whole whole JJ cord-010092-uftc8inx 5712 29 blood blood NN cord-010092-uftc8inx 5712 30 donations donation NNS cord-010092-uftc8inx 5712 31 or or CC cord-010092-uftc8inx 5712 32 12 12 CD cord-010092-uftc8inx 5712 33 component component NN cord-010092-uftc8inx 5712 34 donations donation NNS cord-010092-uftc8inx 5712 35 , , , cord-010092-uftc8inx 5712 36 both both CC cord-010092-uftc8inx 5712 37 within within IN cord-010092-uftc8inx 5712 38 the the DT cord-010092-uftc8inx 5712 39 previous previous JJ cord-010092-uftc8inx 5712 40 year year NN cord-010092-uftc8inx 5712 41 . . . cord-010092-uftc8inx 5713 1 The the DT cord-010092-uftc8inx 5713 2 control control NN cord-010092-uftc8inx 5713 3 group group NN cord-010092-uftc8inx 5713 4 consisted consist VBD cord-010092-uftc8inx 5713 5 of of IN cord-010092-uftc8inx 5713 6 first first JJ cord-010092-uftc8inx 5713 7 - - HYPH cord-010092-uftc8inx 5713 8 time time NN cord-010092-uftc8inx 5713 9 or or CC cord-010092-uftc8inx 5713 10 reactivated reactivate VBN cord-010092-uftc8inx 5713 11 ( ( -LRB- cord-010092-uftc8inx 5713 12 FT FT NNP cord-010092-uftc8inx 5713 13 - - HYPH cord-010092-uftc8inx 5713 14 RA RA NNP cord-010092-uftc8inx 5713 15 ) ) -RRB- cord-010092-uftc8inx 5713 16 donors donor NNS cord-010092-uftc8inx 5713 17 who who WP cord-010092-uftc8inx 5713 18 had have VBD cord-010092-uftc8inx 5713 19 no no DT cord-010092-uftc8inx 5713 20 history history NN cord-010092-uftc8inx 5713 21 of of IN cord-010092-uftc8inx 5713 22 blood blood NN cord-010092-uftc8inx 5713 23 donation donation NN cord-010092-uftc8inx 5713 24 in in IN cord-010092-uftc8inx 5713 25 the the DT cord-010092-uftc8inx 5713 26 past past JJ cord-010092-uftc8inx 5713 27 2 2 CD cord-010092-uftc8inx 5713 28 years year NNS cord-010092-uftc8inx 5713 29 . . . cord-010092-uftc8inx 5714 1 The the DT cord-010092-uftc8inx 5714 2 hemoglobin hemoglobin NN cord-010092-uftc8inx 5714 3 ( ( -LRB- cord-010092-uftc8inx 5714 4 Hb Hb NNP cord-010092-uftc8inx 5714 5 ) ) -RRB- cord-010092-uftc8inx 5714 6 level level NN cord-010092-uftc8inx 5714 7 , , , cord-010092-uftc8inx 5714 8 ferritin ferritin NN cord-010092-uftc8inx 5714 9 level level NN cord-010092-uftc8inx 5714 10 , , , cord-010092-uftc8inx 5714 11 total total JJ cord-010092-uftc8inx 5714 12 iron iron NN cord-010092-uftc8inx 5714 13 binding binding NN cord-010092-uftc8inx 5714 14 capacity capacity NN cord-010092-uftc8inx 5714 15 ( ( -LRB- cord-010092-uftc8inx 5714 16 TIBC TIBC NNP cord-010092-uftc8inx 5714 17 ) ) -RRB- cord-010092-uftc8inx 5714 18 , , , cord-010092-uftc8inx 5714 19 transferrin transferrin NN cord-010092-uftc8inx 5714 20 saturation saturation NN cord-010092-uftc8inx 5714 21 , , , cord-010092-uftc8inx 5714 22 and and CC cord-010092-uftc8inx 5714 23 soluble soluble JJ cord-010092-uftc8inx 5714 24 transferrin transferrin NN cord-010092-uftc8inx 5714 25 receptor receptor NN cord-010092-uftc8inx 5714 26 ( ( -LRB- cord-010092-uftc8inx 5714 27 sTfR sTfR NNP cord-010092-uftc8inx 5714 28 ) ) -RRB- cord-010092-uftc8inx 5714 29 of of IN cord-010092-uftc8inx 5714 30 repeat repeat NN cord-010092-uftc8inx 5714 31 donors donor NNS cord-010092-uftc8inx 5714 32 at at IN cord-010092-uftc8inx 5714 33 high high JJ cord-010092-uftc8inx 5714 34 risk risk NN cord-010092-uftc8inx 5714 35 for for IN cord-010092-uftc8inx 5714 36 iron iron NN cord-010092-uftc8inx 5714 37 deficiency deficiency NN cord-010092-uftc8inx 5714 38 were be VBD cord-010092-uftc8inx 5714 39 compared compare VBN cord-010092-uftc8inx 5714 40 to to IN cord-010092-uftc8inx 5714 41 those those DT cord-010092-uftc8inx 5714 42 of of IN cord-010092-uftc8inx 5714 43 FT FT NNP cord-010092-uftc8inx 5714 44 - - HYPH cord-010092-uftc8inx 5714 45 RA RA NNP cord-010092-uftc8inx 5714 46 donors donor NNS cord-010092-uftc8inx 5714 47 . . . cord-010092-uftc8inx 5715 1 Iron iron NN cord-010092-uftc8inx 5715 2 deficient deficient JJ cord-010092-uftc8inx 5715 3 erythropoiesis erythropoiesis NN cord-010092-uftc8inx 5715 4 ( ( -LRB- cord-010092-uftc8inx 5715 5 IDE IDE NNP cord-010092-uftc8inx 5715 6 ) ) -RRB- cord-010092-uftc8inx 5715 7 is be VBZ cord-010092-uftc8inx 5715 8 defined define VBN cord-010092-uftc8inx 5715 9 as as IN cord-010092-uftc8inx 5715 10 present present JJ cord-010092-uftc8inx 5715 11 if if IN cord-010092-uftc8inx 5715 12 the the DT cord-010092-uftc8inx 5715 13 log log NN cord-010092-uftc8inx 5715 14 of of IN cord-010092-uftc8inx 5715 15 the the DT cord-010092-uftc8inx 5715 16 ratio ratio NN cord-010092-uftc8inx 5715 17 of of IN cord-010092-uftc8inx 5715 18 soluble soluble JJ cord-010092-uftc8inx 5715 19 transferrin transferrin NN cord-010092-uftc8inx 5715 20 receptor receptor NN cord-010092-uftc8inx 5715 21 to to IN cord-010092-uftc8inx 5715 22 ferritin ferritin NN cord-010092-uftc8inx 5715 23 was be VBD cord-010092-uftc8inx 5715 24 ≥ ≥ CD cord-010092-uftc8inx 5715 25 2.07 2.07 CD cord-010092-uftc8inx 5715 26 . . . cord-010092-uftc8inx 5716 1 The the DT cord-010092-uftc8inx 5716 2 repeat repeat NN cord-010092-uftc8inx 5716 3 donors donor NNS cord-010092-uftc8inx 5716 4 took take VBD cord-010092-uftc8inx 5716 5 iron iron NN cord-010092-uftc8inx 5716 6 supplements supplement NNS cord-010092-uftc8inx 5716 7 for for IN cord-010092-uftc8inx 5716 8 4 4 CD cord-010092-uftc8inx 5716 9 weeks week NNS cord-010092-uftc8inx 5716 10 and and CC cord-010092-uftc8inx 5716 11 the the DT cord-010092-uftc8inx 5716 12 same same JJ cord-010092-uftc8inx 5716 13 tests test NNS cord-010092-uftc8inx 5716 14 were be VBD cord-010092-uftc8inx 5716 15 repeated repeat VBN cord-010092-uftc8inx 5716 16 after after IN cord-010092-uftc8inx 5716 17 2 2 CD cord-010092-uftc8inx 5716 18 and and CC cord-010092-uftc8inx 5716 19 4 4 CD cord-010092-uftc8inx 5716 20 weeks week NNS cord-010092-uftc8inx 5716 21 to to TO cord-010092-uftc8inx 5716 22 evaluate evaluate VB cord-010092-uftc8inx 5716 23 their -PRON- PRP$ cord-010092-uftc8inx 5716 24 effects effect NNS cord-010092-uftc8inx 5716 25 and and CC cord-010092-uftc8inx 5716 26 the the DT cord-010092-uftc8inx 5716 27 side side NN cord-010092-uftc8inx 5716 28 effect effect NN cord-010092-uftc8inx 5716 29 and and CC cord-010092-uftc8inx 5716 30 compliance compliance NN cord-010092-uftc8inx 5716 31 was be VBD cord-010092-uftc8inx 5716 32 assessed assess VBN cord-010092-uftc8inx 5716 33 . . . cord-010092-uftc8inx 5717 1 Results result NNS cord-010092-uftc8inx 5717 2 : : : cord-010092-uftc8inx 5718 1 A a DT cord-010092-uftc8inx 5718 2 total total NN cord-010092-uftc8inx 5718 3 of of IN cord-010092-uftc8inx 5718 4 53 53 CD cord-010092-uftc8inx 5718 5 male male NN cord-010092-uftc8inx 5718 6 and and CC cord-010092-uftc8inx 5718 7 57 57 CD cord-010092-uftc8inx 5718 8 female female JJ cord-010092-uftc8inx 5718 9 repeat repeat NN cord-010092-uftc8inx 5718 10 donors donor NNS cord-010092-uftc8inx 5718 11 were be VBD cord-010092-uftc8inx 5718 12 recruited recruit VBN cord-010092-uftc8inx 5718 13 , , , cord-010092-uftc8inx 5718 14 and and CC cord-010092-uftc8inx 5718 15 30 30 CD cord-010092-uftc8inx 5718 16 each each DT cord-010092-uftc8inx 5718 17 male male JJ cord-010092-uftc8inx 5718 18 and and CC cord-010092-uftc8inx 5718 19 female female JJ cord-010092-uftc8inx 5718 20 FT FT NNP cord-010092-uftc8inx 5718 21 - - HYPH cord-010092-uftc8inx 5718 22 RA RA NNP cord-010092-uftc8inx 5718 23 donors donor NNS cord-010092-uftc8inx 5718 24 were be VBD cord-010092-uftc8inx 5718 25 recruited recruit VBN cord-010092-uftc8inx 5718 26 to to IN cord-010092-uftc8inx 5718 27 the the DT cord-010092-uftc8inx 5718 28 control control NN cord-010092-uftc8inx 5718 29 group group NN cord-010092-uftc8inx 5718 30 . . . cord-010092-uftc8inx 5719 1 After after IN cord-010092-uftc8inx 5719 2 4week 4week CD cord-010092-uftc8inx 5719 3 iron iron NN cord-010092-uftc8inx 5719 4 supplementation supplementation NN cord-010092-uftc8inx 5719 5 , , , cord-010092-uftc8inx 5719 6 among among IN cord-010092-uftc8inx 5719 7 male male JJ cord-010092-uftc8inx 5719 8 donors donor NNS cord-010092-uftc8inx 5719 9 , , , cord-010092-uftc8inx 5719 10 the the DT cord-010092-uftc8inx 5719 11 prevalence prevalence NN cord-010092-uftc8inx 5719 12 of of IN cord-010092-uftc8inx 5719 13 : : : cord-010092-uftc8inx 5719 14 low low JJ cord-010092-uftc8inx 5719 15 Hb Hb NNP cord-010092-uftc8inx 5719 16 level level NN cord-010092-uftc8inx 5719 17 ( ( -LRB- cord-010092-uftc8inx 5719 18 < < XX cord-010092-uftc8inx 5719 19 13.0 13.0 CD cord-010092-uftc8inx 5719 20 g g NN cord-010092-uftc8inx 5719 21 / / SYM cord-010092-uftc8inx 5719 22 dL dl NN cord-010092-uftc8inx 5719 23 ) ) -RRB- cord-010092-uftc8inx 5719 24 decreased decrease VBD cord-010092-uftc8inx 5719 25 from from IN cord-010092-uftc8inx 5719 26 24.5 24.5 CD cord-010092-uftc8inx 5719 27 % % NN cord-010092-uftc8inx 5719 28 to to IN cord-010092-uftc8inx 5719 29 1.9 1.9 CD cord-010092-uftc8inx 5719 30 % % NN cord-010092-uftc8inx 5719 31 ; ; , cord-010092-uftc8inx 5719 32 low low JJ cord-010092-uftc8inx 5719 33 ferritin ferritin NN cord-010092-uftc8inx 5719 34 level level NN cord-010092-uftc8inx 5719 35 ( ( -LRB- cord-010092-uftc8inx 5719 36 < < XX cord-010092-uftc8inx 5719 37 15.0 15.0 CD cord-010092-uftc8inx 5719 38 ng ng NNP cord-010092-uftc8inx 5719 39 / / SYM cord-010092-uftc8inx 5719 40 mL ml NN cord-010092-uftc8inx 5719 41 ) ) -RRB- cord-010092-uftc8inx 5719 42 decreased decrease VBD cord-010092-uftc8inx 5719 43 from from IN cord-010092-uftc8inx 5719 44 58.5 58.5 CD cord-010092-uftc8inx 5719 45 % % NN cord-010092-uftc8inx 5719 46 to to IN cord-010092-uftc8inx 5719 47 3.8 3.8 CD cord-010092-uftc8inx 5719 48 % % NN cord-010092-uftc8inx 5719 49 ; ; , cord-010092-uftc8inx 5719 50 high high JJ cord-010092-uftc8inx 5719 51 TIBC TIBC NNP cord-010092-uftc8inx 5719 52 level level NN cord-010092-uftc8inx 5719 53 ( ( -LRB- cord-010092-uftc8inx 5719 54 > > NFP cord-010092-uftc8inx 5719 55 380 380 CD cord-010092-uftc8inx 5719 56 lg lg NNP cord-010092-uftc8inx 5719 57 / / SYM cord-010092-uftc8inx 5719 58 dL dl NN cord-010092-uftc8inx 5719 59 ) ) -RRB- cord-010092-uftc8inx 5719 60 decreased decrease VBD cord-010092-uftc8inx 5719 61 from from IN cord-010092-uftc8inx 5719 62 66.0 66.0 CD cord-010092-uftc8inx 5719 63 % % NN cord-010092-uftc8inx 5719 64 to to IN cord-010092-uftc8inx 5719 65 37.5 37.5 CD cord-010092-uftc8inx 5719 66 % % NN cord-010092-uftc8inx 5719 67 ; ; , cord-010092-uftc8inx 5719 68 low low JJ cord-010092-uftc8inx 5719 69 transferrin transferrin NN cord-010092-uftc8inx 5719 70 saturation saturation NN cord-010092-uftc8inx 5719 71 ( ( -LRB- cord-010092-uftc8inx 5719 72 < < NNP cord-010092-uftc8inx 5719 73 20.0 20.0 CD cord-010092-uftc8inx 5719 74 % % NN cord-010092-uftc8inx 5719 75 ) ) -RRB- cord-010092-uftc8inx 5719 76 decreased decrease VBD cord-010092-uftc8inx 5719 77 from from IN cord-010092-uftc8inx 5719 78 58.5 58.5 CD cord-010092-uftc8inx 5719 79 % % NN cord-010092-uftc8inx 5719 80 to to IN cord-010092-uftc8inx 5719 81 35.4 35.4 CD cord-010092-uftc8inx 5719 82 % % NN cord-010092-uftc8inx 5719 83 ; ; , cord-010092-uftc8inx 5719 84 and and CC cord-010092-uftc8inx 5719 85 IDE IDE NNP cord-010092-uftc8inx 5719 86 ( ( -LRB- cord-010092-uftc8inx 5719 87 sTfR sTfR NNP cord-010092-uftc8inx 5719 88 / / SYM cord-010092-uftc8inx 5719 89 ferritin ferritin NN cord-010092-uftc8inx 5719 90 ≥ ≥ CD cord-010092-uftc8inx 5719 91 2.07 2.07 CD cord-010092-uftc8inx 5719 92 ) ) -RRB- cord-010092-uftc8inx 5719 93 decreased decrease VBD cord-010092-uftc8inx 5719 94 from from IN cord-010092-uftc8inx 5719 95 28.3 28.3 CD cord-010092-uftc8inx 5719 96 % % NN cord-010092-uftc8inx 5719 97 to to IN cord-010092-uftc8inx 5719 98 2.3 2.3 CD cord-010092-uftc8inx 5719 99 % % NN cord-010092-uftc8inx 5719 100 . . . cord-010092-uftc8inx 5720 1 Among among IN cord-010092-uftc8inx 5720 2 female female JJ cord-010092-uftc8inx 5720 3 donors donor NNS cord-010092-uftc8inx 5720 4 , , , cord-010092-uftc8inx 5720 5 the the DT cord-010092-uftc8inx 5720 6 percentage percentage NN cord-010092-uftc8inx 5720 7 of of IN cord-010092-uftc8inx 5720 8 : : : cord-010092-uftc8inx 5720 9 low low JJ cord-010092-uftc8inx 5720 10 Hb Hb NNP cord-010092-uftc8inx 5720 11 level level NN cord-010092-uftc8inx 5720 12 ( ( -LRB- cord-010092-uftc8inx 5720 13 < < XX cord-010092-uftc8inx 5720 14 12.0 12.0 CD cord-010092-uftc8inx 5720 15 g g NN cord-010092-uftc8inx 5720 16 / / SYM cord-010092-uftc8inx 5720 17 dL dl NN cord-010092-uftc8inx 5720 18 ) ) -RRB- cord-010092-uftc8inx 5720 19 decreased decrease VBD cord-010092-uftc8inx 5720 20 from from IN cord-010092-uftc8inx 5720 21 43.9 43.9 CD cord-010092-uftc8inx 5720 22 % % NN cord-010092-uftc8inx 5720 23 to to IN cord-010092-uftc8inx 5720 24 9.8 9.8 CD cord-010092-uftc8inx 5720 25 % % NN cord-010092-uftc8inx 5720 26 ; ; , cord-010092-uftc8inx 5720 27 low low JJ cord-010092-uftc8inx 5720 28 ferritin ferritin NN cord-010092-uftc8inx 5720 29 level level NN cord-010092-uftc8inx 5720 30 ( ( -LRB- cord-010092-uftc8inx 5720 31 < < XX cord-010092-uftc8inx 5720 32 15.0 15.0 CD cord-010092-uftc8inx 5720 33 ng ng NNP cord-010092-uftc8inx 5720 34 / / SYM cord-010092-uftc8inx 5720 35 mL ml NN cord-010092-uftc8inx 5720 36 ) ) -RRB- cord-010092-uftc8inx 5720 37 decreased decrease VBD cord-010092-uftc8inx 5720 38 from from IN cord-010092-uftc8inx 5720 39 78.9 78.9 CD cord-010092-uftc8inx 5720 40 % % NN cord-010092-uftc8inx 5720 41 to to IN cord-010092-uftc8inx 5720 42 11.8 11.8 CD cord-010092-uftc8inx 5720 43 % % NN cord-010092-uftc8inx 5720 44 ; ; , cord-010092-uftc8inx 5720 45 high high JJ cord-010092-uftc8inx 5720 46 TIBC TIBC NNP cord-010092-uftc8inx 5720 47 level level NN cord-010092-uftc8inx 5720 48 ( ( -LRB- cord-010092-uftc8inx 5720 49 > > NFP cord-010092-uftc8inx 5720 50 380 380 CD cord-010092-uftc8inx 5720 51 lg lg NNP cord-010092-uftc8inx 5720 52 / / SYM cord-010092-uftc8inx 5720 53 dL dl NN cord-010092-uftc8inx 5720 54 ) ) -RRB- cord-010092-uftc8inx 5720 55 decreased decrease VBD cord-010092-uftc8inx 5720 56 from from IN cord-010092-uftc8inx 5720 57 68.4 68.4 CD cord-010092-uftc8inx 5720 58 % % NN cord-010092-uftc8inx 5720 59 to to IN cord-010092-uftc8inx 5720 60 24.5 24.5 CD cord-010092-uftc8inx 5720 61 % % NN cord-010092-uftc8inx 5720 62 ; ; , cord-010092-uftc8inx 5720 63 low low JJ cord-010092-uftc8inx 5720 64 transferrin transferrin NN cord-010092-uftc8inx 5720 65 saturation saturation NN cord-010092-uftc8inx 5720 66 level level NN cord-010092-uftc8inx 5720 67 ( ( -LRB- cord-010092-uftc8inx 5720 68 < < NNP cord-010092-uftc8inx 5720 69 20.0 20.0 CD cord-010092-uftc8inx 5720 70 % % NN cord-010092-uftc8inx 5720 71 ) ) -RRB- cord-010092-uftc8inx 5720 72 decreased decrease VBD cord-010092-uftc8inx 5720 73 from from IN cord-010092-uftc8inx 5720 74 70.2 70.2 CD cord-010092-uftc8inx 5720 75 % % NN cord-010092-uftc8inx 5720 76 to to IN cord-010092-uftc8inx 5720 77 22.4 22.4 CD cord-010092-uftc8inx 5720 78 % % NN cord-010092-uftc8inx 5720 79 ; ; , cord-010092-uftc8inx 5720 80 and and CC cord-010092-uftc8inx 5720 81 IDE IDE NNP cord-010092-uftc8inx 5720 82 ( ( -LRB- cord-010092-uftc8inx 5720 83 sTfR sTfR NNP cord-010092-uftc8inx 5720 84 / / SYM cord-010092-uftc8inx 5720 85 ferritin ferritin NN cord-010092-uftc8inx 5720 86 ≥ ≥ CD cord-010092-uftc8inx 5720 87 2.07 2.07 CD cord-010092-uftc8inx 5720 88 ) ) -RRB- cord-010092-uftc8inx 5720 89 decreased decrease VBD cord-010092-uftc8inx 5720 90 from from IN cord-010092-uftc8inx 5720 91 94.7 94.7 CD cord-010092-uftc8inx 5720 92 % % NN cord-010092-uftc8inx 5720 93 to to IN cord-010092-uftc8inx 5720 94 44.4 44.4 CD cord-010092-uftc8inx 5720 95 % % NN cord-010092-uftc8inx 5720 96 . . . cord-010092-uftc8inx 5721 1 In in IN cord-010092-uftc8inx 5721 2 total total JJ cord-010092-uftc8inx 5721 3 , , , cord-010092-uftc8inx 5721 4 15 15 CD cord-010092-uftc8inx 5721 5 male male NN cord-010092-uftc8inx 5721 6 ( ( -LRB- cord-010092-uftc8inx 5721 7 28.3 28.3 CD cord-010092-uftc8inx 5721 8 % % NN cord-010092-uftc8inx 5721 9 ) ) -RRB- cord-010092-uftc8inx 5721 10 and and CC cord-010092-uftc8inx 5721 11 29 29 CD cord-010092-uftc8inx 5721 12 female female JJ cord-010092-uftc8inx 5721 13 ( ( -LRB- cord-010092-uftc8inx 5721 14 56.9 56.9 CD cord-010092-uftc8inx 5721 15 % % NN cord-010092-uftc8inx 5721 16 ) ) -RRB- cord-010092-uftc8inx 5721 17 blood blood NN cord-010092-uftc8inx 5721 18 donors donor NNS cord-010092-uftc8inx 5721 19 reported report VBD cord-010092-uftc8inx 5721 20 undesirable undesirable JJ cord-010092-uftc8inx 5721 21 side side NN cord-010092-uftc8inx 5721 22 effects effect NNS cord-010092-uftc8inx 5721 23 related relate VBN cord-010092-uftc8inx 5721 24 to to IN cord-010092-uftc8inx 5721 25 iron iron NN cord-010092-uftc8inx 5721 26 supplementation supplementation NN cord-010092-uftc8inx 5721 27 . . . cord-010092-uftc8inx 5722 1 A a DT cord-010092-uftc8inx 5722 2 total total NN cord-010092-uftc8inx 5722 3 of of IN cord-010092-uftc8inx 5722 4 38 38 CD cord-010092-uftc8inx 5722 5 male male NN cord-010092-uftc8inx 5722 6 ( ( -LRB- cord-010092-uftc8inx 5722 7 71.7 71.7 CD cord-010092-uftc8inx 5722 8 % % NN cord-010092-uftc8inx 5722 9 ) ) -RRB- cord-010092-uftc8inx 5722 10 and and CC cord-010092-uftc8inx 5722 11 36 36 CD cord-010092-uftc8inx 5722 12 female female JJ cord-010092-uftc8inx 5722 13 ( ( -LRB- cord-010092-uftc8inx 5722 14 70.8 70.8 CD cord-010092-uftc8inx 5722 15 % % NN cord-010092-uftc8inx 5722 16 ) ) -RRB- cord-010092-uftc8inx 5723 1 blood blood NN cord-010092-uftc8inx 5723 2 donors donor NNS cord-010092-uftc8inx 5723 3 were be VBD cord-010092-uftc8inx 5723 4 administered administer VBN cord-010092-uftc8inx 5723 5 iron iron NN cord-010092-uftc8inx 5723 6 supplementations supplementation NNS cord-010092-uftc8inx 5723 7 for for IN cord-010092-uftc8inx 5723 8 28 28 CD cord-010092-uftc8inx 5723 9 days day NNS cord-010092-uftc8inx 5723 10 . . . cord-010092-uftc8inx 5724 1 89 89 CD cord-010092-uftc8inx 5724 2 participants participant NNS cord-010092-uftc8inx 5724 3 ( ( -LRB- cord-010092-uftc8inx 5724 4 85.6 85.6 CD cord-010092-uftc8inx 5724 5 % % NN cord-010092-uftc8inx 5724 6 ) ) -RRB- cord-010092-uftc8inx 5724 7 answered answer VBD cord-010092-uftc8inx 5724 8 that that IN cord-010092-uftc8inx 5724 9 they -PRON- PRP cord-010092-uftc8inx 5724 10 were be VBD cord-010092-uftc8inx 5724 11 willing willing JJ cord-010092-uftc8inx 5724 12 to to TO cord-010092-uftc8inx 5724 13 take take VB cord-010092-uftc8inx 5724 14 a a DT cord-010092-uftc8inx 5724 15 complimentary complimentary JJ cord-010092-uftc8inx 5724 16 iron iron NN cord-010092-uftc8inx 5724 17 supplementation supplementation NN cord-010092-uftc8inx 5724 18 . . . cord-010092-uftc8inx 5725 1 Summary Summary NNP cord-010092-uftc8inx 5725 2 / / SYM cord-010092-uftc8inx 5725 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 5725 4 : : : cord-010092-uftc8inx 5726 1 Ferritin ferritin NN cord-010092-uftc8inx 5726 2 level level NN cord-010092-uftc8inx 5726 3 , , , cord-010092-uftc8inx 5726 4 considered consider VBD cord-010092-uftc8inx 5726 5 a a DT cord-010092-uftc8inx 5726 6 reliable reliable JJ cord-010092-uftc8inx 5726 7 indicator indicator NN cord-010092-uftc8inx 5726 8 of of IN cord-010092-uftc8inx 5726 9 iron iron NN cord-010092-uftc8inx 5726 10 status status NN cord-010092-uftc8inx 5726 11 , , , cord-010092-uftc8inx 5726 12 increased increase VBN cord-010092-uftc8inx 5726 13 and and CC cord-010092-uftc8inx 5726 14 IDE IDE NNP cord-010092-uftc8inx 5726 15 decreased decrease VBD cord-010092-uftc8inx 5726 16 significantly significantly RB cord-010092-uftc8inx 5726 17 after after IN cord-010092-uftc8inx 5726 18 iron iron NN cord-010092-uftc8inx 5726 19 supplementation supplementation NN cord-010092-uftc8inx 5726 20 in in IN cord-010092-uftc8inx 5726 21 female female JJ cord-010092-uftc8inx 5726 22 donor donor NN cord-010092-uftc8inx 5726 23 group group NN cord-010092-uftc8inx 5726 24 , , , cord-010092-uftc8inx 5726 25 but but CC cord-010092-uftc8inx 5726 26 not not RB cord-010092-uftc8inx 5726 27 in in IN cord-010092-uftc8inx 5726 28 male male JJ cord-010092-uftc8inx 5726 29 donor donor NN cord-010092-uftc8inx 5726 30 group group NN cord-010092-uftc8inx 5726 31 , , , cord-010092-uftc8inx 5726 32 compared compare VBN cord-010092-uftc8inx 5726 33 to to IN cord-010092-uftc8inx 5726 34 the the DT cord-010092-uftc8inx 5726 35 ferritin ferritin NN cord-010092-uftc8inx 5726 36 levels level NNS cord-010092-uftc8inx 5726 37 and and CC cord-010092-uftc8inx 5726 38 IDE ide NN cord-010092-uftc8inx 5726 39 of of IN cord-010092-uftc8inx 5726 40 control control NN cord-010092-uftc8inx 5726 41 donors donor NNS cord-010092-uftc8inx 5726 42 . . . cord-010092-uftc8inx 5727 1 Iron iron NN cord-010092-uftc8inx 5727 2 supplementation supplementation NN cord-010092-uftc8inx 5727 3 in in IN cord-010092-uftc8inx 5727 4 repeat repeat NN cord-010092-uftc8inx 5727 5 donors donor NNS cord-010092-uftc8inx 5727 6 at at IN cord-010092-uftc8inx 5727 7 a a DT cord-010092-uftc8inx 5727 8 high high JJ cord-010092-uftc8inx 5727 9 risk risk NN cord-010092-uftc8inx 5727 10 of of IN cord-010092-uftc8inx 5727 11 iron iron NN cord-010092-uftc8inx 5727 12 deficiency deficiency NN cord-010092-uftc8inx 5727 13 was be VBD cord-010092-uftc8inx 5727 14 shown show VBN cord-010092-uftc8inx 5727 15 to to TO cord-010092-uftc8inx 5727 16 reduce reduce VB cord-010092-uftc8inx 5727 17 their -PRON- PRP$ cord-010092-uftc8inx 5727 18 risk risk NN cord-010092-uftc8inx 5727 19 of of IN cord-010092-uftc8inx 5727 20 iron iron NN cord-010092-uftc8inx 5727 21 deficiency deficiency NN cord-010092-uftc8inx 5727 22 or or CC cord-010092-uftc8inx 5727 23 anemia anemia NN cord-010092-uftc8inx 5727 24 irrespective irrespective RB cord-010092-uftc8inx 5727 25 of of IN cord-010092-uftc8inx 5727 26 gender gender NN cord-010092-uftc8inx 5727 27 ; ; : cord-010092-uftc8inx 5727 28 however however RB cord-010092-uftc8inx 5727 29 , , , cord-010092-uftc8inx 5727 30 4-week 4-week CD cord-010092-uftc8inx 5727 31 oral oral JJ cord-010092-uftc8inx 5727 32 iron iron NN cord-010092-uftc8inx 5727 33 supplement supplement NN cord-010092-uftc8inx 5727 34 was be VBD cord-010092-uftc8inx 5727 35 not not RB cord-010092-uftc8inx 5727 36 enough enough JJ cord-010092-uftc8inx 5727 37 to to TO cord-010092-uftc8inx 5727 38 restore restore VB cord-010092-uftc8inx 5727 39 iron iron NN cord-010092-uftc8inx 5727 40 storage storage NN cord-010092-uftc8inx 5727 41 level level NN cord-010092-uftc8inx 5727 42 in in IN cord-010092-uftc8inx 5727 43 the the DT cord-010092-uftc8inx 5727 44 male male JJ cord-010092-uftc8inx 5727 45 donor donor NN cord-010092-uftc8inx 5727 46 group group NN cord-010092-uftc8inx 5727 47 . . . cord-010092-uftc8inx 5728 1 Background background NN cord-010092-uftc8inx 5728 2 : : : cord-010092-uftc8inx 5729 1 C C NNP cord-010092-uftc8inx 5729 2 - - HYPH cord-010092-uftc8inx 5729 3 reactive reactive JJ cord-010092-uftc8inx 5729 4 protein protein NN cord-010092-uftc8inx 5729 5 ( ( -LRB- cord-010092-uftc8inx 5729 6 CRP CRP NNP cord-010092-uftc8inx 5729 7 ) ) -RRB- cord-010092-uftc8inx 5729 8 is be VBZ cord-010092-uftc8inx 5729 9 an an DT cord-010092-uftc8inx 5729 10 acute acute JJ cord-010092-uftc8inx 5729 11 - - HYPH cord-010092-uftc8inx 5729 12 phase phase NN cord-010092-uftc8inx 5729 13 protein protein NN cord-010092-uftc8inx 5729 14 and and CC cord-010092-uftc8inx 5729 15 a a DT cord-010092-uftc8inx 5729 16 non non JJ cord-010092-uftc8inx 5729 17 - - JJ cord-010092-uftc8inx 5729 18 specific specific JJ cord-010092-uftc8inx 5729 19 maker maker NN cord-010092-uftc8inx 5729 20 of of IN cord-010092-uftc8inx 5729 21 inflammation inflammation NN cord-010092-uftc8inx 5729 22 and and CC cord-010092-uftc8inx 5729 23 tissue tissue NN cord-010092-uftc8inx 5729 24 damage damage NN cord-010092-uftc8inx 5729 25 produced produce VBN cord-010092-uftc8inx 5729 26 by by IN cord-010092-uftc8inx 5729 27 the the DT cord-010092-uftc8inx 5729 28 liver liver NN cord-010092-uftc8inx 5729 29 . . . cord-010092-uftc8inx 5730 1 Several several JJ cord-010092-uftc8inx 5730 2 prospective prospective JJ cord-010092-uftc8inx 5730 3 epidemiologic epidemiologic JJ cord-010092-uftc8inx 5730 4 studies study NNS cord-010092-uftc8inx 5730 5 have have VBP cord-010092-uftc8inx 5730 6 demonstrated demonstrate VBN cord-010092-uftc8inx 5730 7 that that IN cord-010092-uftc8inx 5730 8 high high JJ cord-010092-uftc8inx 5730 9 - - HYPH cord-010092-uftc8inx 5730 10 sensitivity sensitivity NN cord-010092-uftc8inx 5730 11 C c NN cord-010092-uftc8inx 5730 12 - - HYPH cord-010092-uftc8inx 5730 13 reactive reactive JJ cord-010092-uftc8inx 5730 14 protein protein NN cord-010092-uftc8inx 5730 15 ( ( -LRB- cord-010092-uftc8inx 5730 16 hs hs NNP cord-010092-uftc8inx 5730 17 - - NNP cord-010092-uftc8inx 5730 18 CRP CRP NNP cord-010092-uftc8inx 5730 19 ) ) -RRB- cord-010092-uftc8inx 5730 20 is be VBZ cord-010092-uftc8inx 5730 21 a a DT cord-010092-uftc8inx 5730 22 predictor predictor NN cord-010092-uftc8inx 5730 23 of of IN cord-010092-uftc8inx 5730 24 future future JJ cord-010092-uftc8inx 5730 25 coronary coronary JJ cord-010092-uftc8inx 5730 26 events event NNS cord-010092-uftc8inx 5730 27 among among IN cord-010092-uftc8inx 5730 28 apparently apparently RB cord-010092-uftc8inx 5730 29 healthy healthy JJ cord-010092-uftc8inx 5730 30 men man NNS cord-010092-uftc8inx 5730 31 and and CC cord-010092-uftc8inx 5730 32 women woman NNS cord-010092-uftc8inx 5730 33 , , , cord-010092-uftc8inx 5730 34 hs hs NNP cord-010092-uftc8inx 5730 35 - - HYPH cord-010092-uftc8inx 5730 36 CRP CRP NNP cord-010092-uftc8inx 5730 37 level level NN cord-010092-uftc8inx 5730 38 greater great JJR cord-010092-uftc8inx 5730 39 than than IN cord-010092-uftc8inx 5730 40 3 3 CD cord-010092-uftc8inx 5730 41 mg mg NNP cord-010092-uftc8inx 5730 42 / / SYM cord-010092-uftc8inx 5730 43 L L NNP cord-010092-uftc8inx 5730 44 has have VBZ cord-010092-uftc8inx 5730 45 been be VBN cord-010092-uftc8inx 5730 46 independently independently RB cord-010092-uftc8inx 5730 47 associated associate VBN cord-010092-uftc8inx 5730 48 with with IN cord-010092-uftc8inx 5730 49 a a DT cord-010092-uftc8inx 5730 50 60 60 CD cord-010092-uftc8inx 5730 51 % % NN cord-010092-uftc8inx 5730 52 excess excess JJ cord-010092-uftc8inx 5730 53 risk risk NN cord-010092-uftc8inx 5730 54 in in IN cord-010092-uftc8inx 5730 55 incident incident NN cord-010092-uftc8inx 5730 56 of of IN cord-010092-uftc8inx 5730 57 coronary coronary JJ cord-010092-uftc8inx 5730 58 heart heart NN cord-010092-uftc8inx 5730 59 disease disease NN cord-010092-uftc8inx 5730 60 ( ( -LRB- cord-010092-uftc8inx 5730 61 CHD CHD NNP cord-010092-uftc8inx 5730 62 ) ) -RRB- cord-010092-uftc8inx 5730 63 as as IN cord-010092-uftc8inx 5730 64 compared compare VBN cord-010092-uftc8inx 5730 65 with with IN cord-010092-uftc8inx 5730 66 levels level NNS cord-010092-uftc8inx 5730 67 less less JJR cord-010092-uftc8inx 5730 68 than than IN cord-010092-uftc8inx 5730 69 1 1 CD cord-010092-uftc8inx 5730 70 mg mg NNP cord-010092-uftc8inx 5730 71 / / SYM cord-010092-uftc8inx 5730 72 L. L. NNP cord-010092-uftc8inx 5730 73 Frequent frequent JJ cord-010092-uftc8inx 5730 74 blood blood NN cord-010092-uftc8inx 5730 75 donation donation NN cord-010092-uftc8inx 5730 76 has have VBZ cord-010092-uftc8inx 5730 77 been be VBN cord-010092-uftc8inx 5730 78 associated associate VBN cord-010092-uftc8inx 5730 79 with with IN cord-010092-uftc8inx 5730 80 a a DT cord-010092-uftc8inx 5730 81 lower low JJR cord-010092-uftc8inx 5730 82 incidence incidence NN cord-010092-uftc8inx 5730 83 of of IN cord-010092-uftc8inx 5730 84 Coronary coronary JJ cord-010092-uftc8inx 5730 85 artery artery NN cord-010092-uftc8inx 5730 86 disease disease NN cord-010092-uftc8inx 5730 87 ( ( -LRB- cord-010092-uftc8inx 5730 88 CAD CAD NNP cord-010092-uftc8inx 5730 89 ) ) -RRB- cord-010092-uftc8inx 5730 90 ; ; : cord-010092-uftc8inx 5730 91 however however RB cord-010092-uftc8inx 5730 92 , , , cord-010092-uftc8inx 5730 93 there there EX cord-010092-uftc8inx 5730 94 is be VBZ cord-010092-uftc8inx 5730 95 a a DT cord-010092-uftc8inx 5730 96 dearth dearth NN cord-010092-uftc8inx 5730 97 of of IN cord-010092-uftc8inx 5730 98 information information NN cord-010092-uftc8inx 5730 99 on on IN cord-010092-uftc8inx 5730 100 serum serum NN cord-010092-uftc8inx 5730 101 levels level NNS cord-010092-uftc8inx 5730 102 of of IN cord-010092-uftc8inx 5730 103 CRP crp NN cord-010092-uftc8inx 5730 104 in in IN cord-010092-uftc8inx 5730 105 the the DT cord-010092-uftc8inx 5730 106 Nigerian nigerian JJ cord-010092-uftc8inx 5730 107 donor donor NN cord-010092-uftc8inx 5730 108 population population NN cord-010092-uftc8inx 5730 109 . . . cord-010092-uftc8inx 5731 1 Aims aim VBZ cord-010092-uftc8inx 5731 2 : : : cord-010092-uftc8inx 5732 1 To to TO cord-010092-uftc8inx 5732 2 investigate investigate VB cord-010092-uftc8inx 5732 3 whether whether IN cord-010092-uftc8inx 5732 4 regular regular JJ cord-010092-uftc8inx 5732 5 blood blood NN cord-010092-uftc8inx 5732 6 donation donation NN cord-010092-uftc8inx 5732 7 is be VBZ cord-010092-uftc8inx 5732 8 associated associate VBN cord-010092-uftc8inx 5732 9 with with IN cord-010092-uftc8inx 5732 10 lower low JJR cord-010092-uftc8inx 5732 11 serum serum NN cord-010092-uftc8inx 5732 12 hs hs JJ cord-010092-uftc8inx 5732 13 - - HYPH cord-010092-uftc8inx 5732 14 CRP crp JJ cord-010092-uftc8inx 5732 15 level level NN cord-010092-uftc8inx 5732 16 in in IN cord-010092-uftc8inx 5732 17 Nigerian nigerian JJ cord-010092-uftc8inx 5732 18 blood blood NN cord-010092-uftc8inx 5732 19 donors donor NNS cord-010092-uftc8inx 5732 20 . . . cord-010092-uftc8inx 5733 1 Methods method NNS cord-010092-uftc8inx 5733 2 : : : cord-010092-uftc8inx 5734 1 A a DT cord-010092-uftc8inx 5734 2 descriptive descriptive JJ cord-010092-uftc8inx 5734 3 cross cross JJ cord-010092-uftc8inx 5734 4 - - JJ cord-010092-uftc8inx 5734 5 sectional sectional JJ cord-010092-uftc8inx 5734 6 study study NN cord-010092-uftc8inx 5734 7 carried carry VBD cord-010092-uftc8inx 5734 8 out out RP cord-010092-uftc8inx 5734 9 to to TO cord-010092-uftc8inx 5734 10 measure measure VB cord-010092-uftc8inx 5734 11 serum serum NN cord-010092-uftc8inx 5734 12 levels level NNS cord-010092-uftc8inx 5734 13 of of IN cord-010092-uftc8inx 5734 14 high high JJ cord-010092-uftc8inx 5734 15 sensitive sensitive JJ cord-010092-uftc8inx 5734 16 C c NN cord-010092-uftc8inx 5734 17 - - HYPH cord-010092-uftc8inx 5734 18 reactive reactive JJ cord-010092-uftc8inx 5734 19 protein protein NN cord-010092-uftc8inx 5734 20 ( ( -LRB- cord-010092-uftc8inx 5734 21 hs hs NNP cord-010092-uftc8inx 5734 22 - - NNP cord-010092-uftc8inx 5734 23 CRP CRP NNP cord-010092-uftc8inx 5734 24 ) ) -RRB- cord-010092-uftc8inx 5734 25 and and CC cord-010092-uftc8inx 5734 26 ferritin ferritin NN cord-010092-uftc8inx 5734 27 among among IN cord-010092-uftc8inx 5734 28 blood blood NN cord-010092-uftc8inx 5734 29 donors donor NNS cord-010092-uftc8inx 5734 30 attending attend VBG cord-010092-uftc8inx 5734 31 the the DT cord-010092-uftc8inx 5734 32 donors donor NNS cord-010092-uftc8inx 5734 33 ' ' POS cord-010092-uftc8inx 5734 34 clinic clinic NN cord-010092-uftc8inx 5734 35 in in IN cord-010092-uftc8inx 5734 36 Lagos Lagos NNP cord-010092-uftc8inx 5734 37 University University NNP cord-010092-uftc8inx 5734 38 Teaching Teaching NNP cord-010092-uftc8inx 5734 39 Hospital Hospital NNP cord-010092-uftc8inx 5734 40 ( ( -LRB- cord-010092-uftc8inx 5734 41 LUTH LUTH NNP cord-010092-uftc8inx 5734 42 ) ) -RRB- cord-010092-uftc8inx 5734 43 . . . cord-010092-uftc8inx 5735 1 Subjects subject NNS cord-010092-uftc8inx 5735 2 who who WP cord-010092-uftc8inx 5735 3 did do VBD cord-010092-uftc8inx 5735 4 not not RB cord-010092-uftc8inx 5735 5 meet meet VB cord-010092-uftc8inx 5735 6 criteria criterion NNS cord-010092-uftc8inx 5735 7 for for IN cord-010092-uftc8inx 5735 8 blood blood NN cord-010092-uftc8inx 5735 9 donation donation NN cord-010092-uftc8inx 5735 10 were be VBD cord-010092-uftc8inx 5735 11 excluded exclude VBN cord-010092-uftc8inx 5735 12 . . . cord-010092-uftc8inx 5736 1 Additional additional JJ cord-010092-uftc8inx 5736 2 data datum NNS cord-010092-uftc8inx 5736 3 on on IN cord-010092-uftc8inx 5736 4 sociodemographic sociodemographic JJ cord-010092-uftc8inx 5736 5 characteristics characteristic NNS cord-010092-uftc8inx 5736 6 was be VBD cord-010092-uftc8inx 5736 7 collected collect VBN cord-010092-uftc8inx 5736 8 using use VBG cord-010092-uftc8inx 5736 9 interviewer interviewer NN cord-010092-uftc8inx 5736 10 - - HYPH cord-010092-uftc8inx 5736 11 administered administer VBN cord-010092-uftc8inx 5736 12 questionnaire questionnaire NN cord-010092-uftc8inx 5736 13 . . . cord-010092-uftc8inx 5737 1 Serum serum NN cord-010092-uftc8inx 5737 2 ferritin ferritin NN cord-010092-uftc8inx 5737 3 was be VBD cord-010092-uftc8inx 5737 4 analysed analyse VBN cord-010092-uftc8inx 5737 5 using use VBG cord-010092-uftc8inx 5737 6 chemiluminescent chemiluminescent NN cord-010092-uftc8inx 5737 7 microparticle microparticle NNP cord-010092-uftc8inx 5737 8 immunoassay immunoassay NNP cord-010092-uftc8inx 5737 9 performed perform VBN cord-010092-uftc8inx 5737 10 on on IN cord-010092-uftc8inx 5737 11 the the DT cord-010092-uftc8inx 5737 12 Abbott Abbott NNP cord-010092-uftc8inx 5737 13 Architect Architect NNP cord-010092-uftc8inx 5737 14 ci4100 ci4100 NNP cord-010092-uftc8inx 5737 15 ( ( -LRB- cord-010092-uftc8inx 5737 16 Abbott Abbott NNP cord-010092-uftc8inx 5737 17 Laboratories Laboratories NNP cord-010092-uftc8inx 5737 18 , , , cord-010092-uftc8inx 5737 19 Abbott Abbott NNP cord-010092-uftc8inx 5737 20 Park Park NNP cord-010092-uftc8inx 5737 21 , , , cord-010092-uftc8inx 5737 22 IL IL NNP cord-010092-uftc8inx 5737 23 , , , cord-010092-uftc8inx 5737 24 USA USA NNP cord-010092-uftc8inx 5737 25 ) ) -RRB- cord-010092-uftc8inx 5737 26 . . . cord-010092-uftc8inx 5738 1 Serum serum NN cord-010092-uftc8inx 5738 2 concentration concentration NN cord-010092-uftc8inx 5738 3 of of IN cord-010092-uftc8inx 5738 4 hsCRP hscrp NN cord-010092-uftc8inx 5738 5 was be VBD cord-010092-uftc8inx 5738 6 estimated estimate VBN cord-010092-uftc8inx 5738 7 by by IN cord-010092-uftc8inx 5738 8 immunoturbidimetry immunoturbidimetry NNP cord-010092-uftc8inx 5738 9 method method NN cord-010092-uftc8inx 5738 10 using use VBG cord-010092-uftc8inx 5738 11 analytical analytical JJ cord-010092-uftc8inx 5738 12 kits kit NNS cord-010092-uftc8inx 5738 13 from from IN cord-010092-uftc8inx 5738 14 Erba Erba NNP cord-010092-uftc8inx 5738 15 Diagnostics Diagnostics NNP cord-010092-uftc8inx 5738 16 Mannheim Mannheim NNP cord-010092-uftc8inx 5738 17 GmbH GmbH NNP cord-010092-uftc8inx 5738 18 in in IN cord-010092-uftc8inx 5738 19 semi semi JJ cord-010092-uftc8inx 5738 20 - - JJ cord-010092-uftc8inx 5738 21 autoanalyzer autoanalyzer JJ cord-010092-uftc8inx 5738 22 ( ( -LRB- cord-010092-uftc8inx 5738 23 XL XL NNP cord-010092-uftc8inx 5738 24 180 180 CD cord-010092-uftc8inx 5738 25 , , , cord-010092-uftc8inx 5738 26 Erba Erba NNP cord-010092-uftc8inx 5738 27 Mannheim Mannheim NNP cord-010092-uftc8inx 5738 28 ) ) -RRB- cord-010092-uftc8inx 5738 29 . . . cord-010092-uftc8inx 5739 1 Data datum NNS cord-010092-uftc8inx 5739 2 was be VBD cord-010092-uftc8inx 5739 3 analysed analyse VBN cord-010092-uftc8inx 5739 4 using use VBG cord-010092-uftc8inx 5739 5 Stata Stata NNP cord-010092-uftc8inx 5739 6 version version NN cord-010092-uftc8inx 5739 7 15 15 CD cord-010092-uftc8inx 5739 8 ( ( -LRB- cord-010092-uftc8inx 5739 9 Stata Stata NNP cord-010092-uftc8inx 5739 10 Corp Corp NNP cord-010092-uftc8inx 5739 11 ) ) -RRB- cord-010092-uftc8inx 5739 12 statistical statistical JJ cord-010092-uftc8inx 5739 13 software software NN cord-010092-uftc8inx 5739 14 . . . cord-010092-uftc8inx 5740 1 Results result NNS cord-010092-uftc8inx 5740 2 : : : cord-010092-uftc8inx 5741 1 In in IN cord-010092-uftc8inx 5741 2 total total NN cord-010092-uftc8inx 5741 3 of of IN cord-010092-uftc8inx 5741 4 313 313 CD cord-010092-uftc8inx 5741 5 blood blood NN cord-010092-uftc8inx 5741 6 donors donor NNS cord-010092-uftc8inx 5741 7 , , , cord-010092-uftc8inx 5741 8 278(90.8 278(90.8 CD cord-010092-uftc8inx 5741 9 % % NN cord-010092-uftc8inx 5741 10 ) ) -RRB- cord-010092-uftc8inx 5741 11 were be VBD cord-010092-uftc8inx 5741 12 males male NNS cord-010092-uftc8inx 5741 13 and and CC cord-010092-uftc8inx 5741 14 28(9.2 28(9.2 CD cord-010092-uftc8inx 5741 15 % % NN cord-010092-uftc8inx 5741 16 ) ) -RRB- cord-010092-uftc8inx 5741 17 were be VBD cord-010092-uftc8inx 5741 18 females female NNS cord-010092-uftc8inx 5741 19 , , , cord-010092-uftc8inx 5741 20 the the DT cord-010092-uftc8inx 5741 21 mean mean JJ cord-010092-uftc8inx 5741 22 age age NN cord-010092-uftc8inx 5741 23 was be VBD cord-010092-uftc8inx 5741 24 32.3 32.3 CD cord-010092-uftc8inx 5741 25 AE AE NNP cord-010092-uftc8inx 5741 26 9.3 9.3 CD cord-010092-uftc8inx 5741 27 years year NNS cord-010092-uftc8inx 5741 28 . . . cord-010092-uftc8inx 5742 1 Two two CD cord-010092-uftc8inx 5742 2 hundred hundred CD cord-010092-uftc8inx 5742 3 and and CC cord-010092-uftc8inx 5742 4 thirty thirty CD cord-010092-uftc8inx 5742 5 four four CD cord-010092-uftc8inx 5742 6 ( ( -LRB- cord-010092-uftc8inx 5742 7 74.8 74.8 CD cord-010092-uftc8inx 5742 8 % % NN cord-010092-uftc8inx 5742 9 ) ) -RRB- cord-010092-uftc8inx 5742 10 were be VBD cord-010092-uftc8inx 5742 11 first first JJ cord-010092-uftc8inx 5742 12 time time NN cord-010092-uftc8inx 5742 13 donors donor NNS cord-010092-uftc8inx 5742 14 and and CC cord-010092-uftc8inx 5742 15 79(25.2 79(25.2 CD cord-010092-uftc8inx 5742 16 % % NN cord-010092-uftc8inx 5742 17 ) ) -RRB- cord-010092-uftc8inx 5742 18 were be VBD cord-010092-uftc8inx 5742 19 regular regular JJ cord-010092-uftc8inx 5742 20 donors donor NNS cord-010092-uftc8inx 5742 21 , , , cord-010092-uftc8inx 5742 22 serum serum NN cord-010092-uftc8inx 5742 23 levels level NNS cord-010092-uftc8inx 5742 24 of of IN cord-010092-uftc8inx 5742 25 hs hs NNP cord-010092-uftc8inx 5742 26 - - NNP cord-010092-uftc8inx 5742 27 CRP CRP NNP cord-010092-uftc8inx 5742 28 was be VBD cord-010092-uftc8inx 5742 29 slightly slightly RB cord-010092-uftc8inx 5742 30 higher high JJR cord-010092-uftc8inx 5742 31 in in IN cord-010092-uftc8inx 5742 32 regular regular JJ cord-010092-uftc8inx 5742 33 donors donor NNS cord-010092-uftc8inx 5742 34 compared compare VBN cord-010092-uftc8inx 5742 35 to to IN cord-010092-uftc8inx 5742 36 first first JJ cord-010092-uftc8inx 5742 37 time time NN cord-010092-uftc8inx 5742 38 donors donor NNS cord-010092-uftc8inx 5742 39 ( ( -LRB- cord-010092-uftc8inx 5742 40 0.95 0.95 CD cord-010092-uftc8inx 5742 41 AE AE NNP cord-010092-uftc8inx 5742 42 3.7 3.7 CD cord-010092-uftc8inx 5742 43 vs vs IN cord-010092-uftc8inx 5742 44 0.35 0.35 CD cord-010092-uftc8inx 5742 45 AE AE NNP cord-010092-uftc8inx 5742 46 1.7 1.7 CD cord-010092-uftc8inx 5742 47 mg mg NNP cord-010092-uftc8inx 5742 48 / / SYM cord-010092-uftc8inx 5742 49 L L NNP cord-010092-uftc8inx 5742 50 , , , cord-010092-uftc8inx 5742 51 P p NN cord-010092-uftc8inx 5742 52 = = SYM cord-010092-uftc8inx 5742 53 0.06 0.06 CD cord-010092-uftc8inx 5742 54 ) ) -RRB- cord-010092-uftc8inx 5742 55 though though IN cord-010092-uftc8inx 5742 56 the the DT cord-010092-uftc8inx 5742 57 difference difference NN cord-010092-uftc8inx 5742 58 was be VBD cord-010092-uftc8inx 5742 59 not not RB cord-010092-uftc8inx 5742 60 significant significant JJ cord-010092-uftc8inx 5742 61 . . . cord-010092-uftc8inx 5743 1 Serum serum NN cord-010092-uftc8inx 5743 2 levels level NNS cord-010092-uftc8inx 5743 3 of of IN cord-010092-uftc8inx 5743 4 ferritin ferritin NN cord-010092-uftc8inx 5743 5 was be VBD cord-010092-uftc8inx 5743 6 significantly significantly RB cord-010092-uftc8inx 5743 7 higher high JJR cord-010092-uftc8inx 5743 8 in in IN cord-010092-uftc8inx 5743 9 first first JJ cord-010092-uftc8inx 5743 10 time time NN cord-010092-uftc8inx 5743 11 donors donor NNS cord-010092-uftc8inx 5743 12 compared compare VBN cord-010092-uftc8inx 5743 13 to to IN cord-010092-uftc8inx 5743 14 regular regular JJ cord-010092-uftc8inx 5743 15 donors donor NNS cord-010092-uftc8inx 5743 16 ( ( -LRB- cord-010092-uftc8inx 5743 17 87.56 87.56 CD cord-010092-uftc8inx 5743 18 AE AE NNP cord-010092-uftc8inx 5743 19 23.9 23.9 CD cord-010092-uftc8inx 5743 20 vs vs IN cord-010092-uftc8inx 5743 21 46.44 46.44 CD cord-010092-uftc8inx 5743 22 AE AE NNP cord-010092-uftc8inx 5743 23 31.4 31.4 CD cord-010092-uftc8inx 5743 24 ng ng NNP cord-010092-uftc8inx 5743 25 / / SYM cord-010092-uftc8inx 5743 26 mL mL NNP cord-010092-uftc8inx 5743 27 , , , cord-010092-uftc8inx 5743 28 P p NN cord-010092-uftc8inx 5743 29 = = SYM cord-010092-uftc8inx 5743 30 0.02 0.02 CD cord-010092-uftc8inx 5743 31 ) ) -RRB- cord-010092-uftc8inx 5743 32 . . . cord-010092-uftc8inx 5744 1 Interestingly interestingly RB cord-010092-uftc8inx 5744 2 , , , cord-010092-uftc8inx 5744 3 levels level NNS cord-010092-uftc8inx 5744 4 of of IN cord-010092-uftc8inx 5744 5 serum serum NN cord-010092-uftc8inx 5744 6 hs hs NNP cord-010092-uftc8inx 5744 7 - - HYPH cord-010092-uftc8inx 5744 8 CRP CRP NNP cord-010092-uftc8inx 5744 9 were be VBD cord-010092-uftc8inx 5744 10 significantly significantly RB cord-010092-uftc8inx 5744 11 higher high JJR cord-010092-uftc8inx 5744 12 in in IN cord-010092-uftc8inx 5744 13 male male NN cord-010092-uftc8inx 5744 14 than than IN cord-010092-uftc8inx 5744 15 female female JJ cord-010092-uftc8inx 5744 16 population population NN cord-010092-uftc8inx 5744 17 ( ( -LRB- cord-010092-uftc8inx 5744 18 0.52 0.52 CD cord-010092-uftc8inx 5744 19 AE AE NNP cord-010092-uftc8inx 5744 20 2.4 2.4 CD cord-010092-uftc8inx 5744 21 vs vs IN cord-010092-uftc8inx 5744 22 0.17 0.17 CD cord-010092-uftc8inx 5744 23 AE AE NNP cord-010092-uftc8inx 5744 24 0.2 0.2 CD cord-010092-uftc8inx 5744 25 mg mg NNP cord-010092-uftc8inx 5744 26 / / SYM cord-010092-uftc8inx 5744 27 L L NNP cord-010092-uftc8inx 5744 28 , , , cord-010092-uftc8inx 5744 29 P p NN cord-010092-uftc8inx 5744 30 < < XX cord-010092-uftc8inx 5744 31 0.03 0.03 CD cord-010092-uftc8inx 5744 32 ) ) -RRB- cord-010092-uftc8inx 5744 33 and and CC cord-010092-uftc8inx 5744 34 smokers smoker NNS cord-010092-uftc8inx 5744 35 than than IN cord-010092-uftc8inx 5744 36 non non JJ cord-010092-uftc8inx 5744 37 - - NNS cord-010092-uftc8inx 5744 38 smokers smoker NNS cord-010092-uftc8inx 5744 39 ( ( -LRB- cord-010092-uftc8inx 5745 1 1.4 1.4 CD cord-010092-uftc8inx 5745 2 AE AE NNP cord-010092-uftc8inx 5745 3 4.6 4.6 CD cord-010092-uftc8inx 5745 4 mg mg NNP cord-010092-uftc8inx 5745 5 / / SYM cord-010092-uftc8inx 5745 6 L L NNP cord-010092-uftc8inx 5745 7 vs vs IN cord-010092-uftc8inx 5745 8 0.4 0.4 CD cord-010092-uftc8inx 5746 1 AE AE NNP cord-010092-uftc8inx 5746 2 1.9 1.9 CD cord-010092-uftc8inx 5746 3 mg mg NNP cord-010092-uftc8inx 5746 4 / / SYM cord-010092-uftc8inx 5746 5 L L NNP cord-010092-uftc8inx 5746 6 , , , cord-010092-uftc8inx 5746 7 P p NN cord-010092-uftc8inx 5746 8 = = SYM cord-010092-uftc8inx 5746 9 0.02 0.02 CD cord-010092-uftc8inx 5746 10 ) ) -RRB- cord-010092-uftc8inx 5746 11 . . . cord-010092-uftc8inx 5747 1 Correlation correlation NN cord-010092-uftc8inx 5747 2 analysis analysis NN cord-010092-uftc8inx 5747 3 showed show VBD cord-010092-uftc8inx 5747 4 no no DT cord-010092-uftc8inx 5747 5 correlation correlation NN cord-010092-uftc8inx 5747 6 between between IN cord-010092-uftc8inx 5747 7 serum serum NN cord-010092-uftc8inx 5747 8 hsCRP hscrp NN cord-010092-uftc8inx 5747 9 and and CC cord-010092-uftc8inx 5747 10 serum serum NN cord-010092-uftc8inx 5747 11 ferritin ferritin NN cord-010092-uftc8inx 5747 12 levels level NNS cord-010092-uftc8inx 5747 13 in in IN cord-010092-uftc8inx 5747 14 both both DT cord-010092-uftc8inx 5747 15 categories category NNS cord-010092-uftc8inx 5747 16 of of IN cord-010092-uftc8inx 5747 17 donors donor NNS cord-010092-uftc8inx 5747 18 while while IN cord-010092-uftc8inx 5747 19 there there EX cord-010092-uftc8inx 5747 20 was be VBD cord-010092-uftc8inx 5747 21 a a DT cord-010092-uftc8inx 5747 22 weak weak JJ cord-010092-uftc8inx 5747 23 positive positive JJ cord-010092-uftc8inx 5747 24 correlation correlation NN cord-010092-uftc8inx 5747 25 between between IN cord-010092-uftc8inx 5747 26 hs hs NNP cord-010092-uftc8inx 5747 27 - - JJ cord-010092-uftc8inx 5747 28 CRP CRP NNP cord-010092-uftc8inx 5747 29 levels level NNS cord-010092-uftc8inx 5747 30 and and CC cord-010092-uftc8inx 5747 31 White White NNP cord-010092-uftc8inx 5747 32 Blood Blood NNP cord-010092-uftc8inx 5747 33 Cells cell NNS cord-010092-uftc8inx 5747 34 among among IN cord-010092-uftc8inx 5747 35 the the DT cord-010092-uftc8inx 5747 36 first first JJ cord-010092-uftc8inx 5747 37 time time NN cord-010092-uftc8inx 5747 38 donors donor NNS cord-010092-uftc8inx 5747 39 . . . cord-010092-uftc8inx 5748 1 Summary Summary NNP cord-010092-uftc8inx 5748 2 / / SYM cord-010092-uftc8inx 5748 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 5748 4 : : : cord-010092-uftc8inx 5749 1 This this DT cord-010092-uftc8inx 5749 2 present present JJ cord-010092-uftc8inx 5749 3 study study NN cord-010092-uftc8inx 5749 4 did do VBD cord-010092-uftc8inx 5749 5 not not RB cord-010092-uftc8inx 5749 6 reveal reveal VB cord-010092-uftc8inx 5749 7 any any DT cord-010092-uftc8inx 5749 8 decrease decrease NN cord-010092-uftc8inx 5749 9 in in IN cord-010092-uftc8inx 5749 10 baseline baseline JJ cord-010092-uftc8inx 5749 11 levels level NNS cord-010092-uftc8inx 5749 12 of of IN cord-010092-uftc8inx 5749 13 serum serum NN cord-010092-uftc8inx 5749 14 hs hs NNP cord-010092-uftc8inx 5749 15 - - HYPH cord-010092-uftc8inx 5749 16 CRP CRP NNP cord-010092-uftc8inx 5749 17 with with IN cord-010092-uftc8inx 5749 18 regular regular JJ cord-010092-uftc8inx 5749 19 blood blood NN cord-010092-uftc8inx 5749 20 donation donation NN cord-010092-uftc8inx 5749 21 ; ; : cord-010092-uftc8inx 5749 22 smoking smoke VBG cord-010092-uftc8inx 5749 23 status status NN cord-010092-uftc8inx 5749 24 and and CC cord-010092-uftc8inx 5749 25 gender gender NN cord-010092-uftc8inx 5749 26 were be VBD cord-010092-uftc8inx 5749 27 however however RB cord-010092-uftc8inx 5749 28 associated associate VBN cord-010092-uftc8inx 5749 29 with with IN cord-010092-uftc8inx 5749 30 an an DT cord-010092-uftc8inx 5749 31 increase increase NN cord-010092-uftc8inx 5749 32 in in IN cord-010092-uftc8inx 5749 33 baseline baseline JJ cord-010092-uftc8inx 5749 34 hsCRP hscrp NN cord-010092-uftc8inx 5749 35 . . . cord-010092-uftc8inx 5750 1 This this DT cord-010092-uftc8inx 5750 2 finding finding NN cord-010092-uftc8inx 5750 3 suggests suggest VBZ cord-010092-uftc8inx 5750 4 that that IN cord-010092-uftc8inx 5750 5 hs hs NNP cord-010092-uftc8inx 5750 6 - - HYPH cord-010092-uftc8inx 5750 7 CRP CRP NNP cord-010092-uftc8inx 5750 8 level level NN cord-010092-uftc8inx 5750 9 might may MD cord-010092-uftc8inx 5750 10 not not RB cord-010092-uftc8inx 5750 11 be be VB cord-010092-uftc8inx 5750 12 a a DT cord-010092-uftc8inx 5750 13 useful useful JJ cord-010092-uftc8inx 5750 14 marker marker NN cord-010092-uftc8inx 5750 15 of of IN cord-010092-uftc8inx 5750 16 future future JJ cord-010092-uftc8inx 5750 17 coronary coronary JJ cord-010092-uftc8inx 5750 18 events event NNS cord-010092-uftc8inx 5750 19 in in IN cord-010092-uftc8inx 5750 20 healthy healthy JJ cord-010092-uftc8inx 5750 21 blood blood NN cord-010092-uftc8inx 5750 22 donors donor NNS cord-010092-uftc8inx 5750 23 in in IN cord-010092-uftc8inx 5750 24 Nigeria Nigeria NNP cord-010092-uftc8inx 5750 25 . . . cord-010092-uftc8inx 5751 1 Background background NN cord-010092-uftc8inx 5751 2 : : : cord-010092-uftc8inx 5752 1 Because because IN cord-010092-uftc8inx 5752 2 the the DT cord-010092-uftc8inx 5752 3 blood blood NN cord-010092-uftc8inx 5752 4 donation donation NN cord-010092-uftc8inx 5752 5 removes remove VBZ cord-010092-uftc8inx 5752 6 250 250 CD cord-010092-uftc8inx 5752 7 mg mg NN cord-010092-uftc8inx 5752 8 of of IN cord-010092-uftc8inx 5752 9 iron iron NN cord-010092-uftc8inx 5752 10 from from IN cord-010092-uftc8inx 5752 11 the the DT cord-010092-uftc8inx 5752 12 donor donor NN cord-010092-uftc8inx 5752 13 , , , cord-010092-uftc8inx 5752 14 iron iron NN cord-010092-uftc8inx 5752 15 deficiency deficiency NN cord-010092-uftc8inx 5752 16 , , , cord-010092-uftc8inx 5752 17 frequently frequently RB cord-010092-uftc8inx 5752 18 occurs occur VBZ cord-010092-uftc8inx 5752 19 in in IN cord-010092-uftc8inx 5752 20 regular regular JJ cord-010092-uftc8inx 5752 21 blood blood NN cord-010092-uftc8inx 5752 22 donors donor NNS cord-010092-uftc8inx 5752 23 leading lead VBG cord-010092-uftc8inx 5752 24 at at IN cord-010092-uftc8inx 5752 25 a a DT cord-010092-uftc8inx 5752 26 long long JJ cord-010092-uftc8inx 5752 27 term term NN cord-010092-uftc8inx 5752 28 to to IN cord-010092-uftc8inx 5752 29 the the DT cord-010092-uftc8inx 5752 30 anemia anemia NN cord-010092-uftc8inx 5752 31 . . . cord-010092-uftc8inx 5753 1 Aims aim VBZ cord-010092-uftc8inx 5753 2 : : : cord-010092-uftc8inx 5753 3 To to TO cord-010092-uftc8inx 5753 4 determine determine VB cord-010092-uftc8inx 5753 5 the the DT cord-010092-uftc8inx 5753 6 effect effect NN cord-010092-uftc8inx 5753 7 of of IN cord-010092-uftc8inx 5753 8 blood blood NN cord-010092-uftc8inx 5753 9 donations donation NNS cord-010092-uftc8inx 5753 10 on on IN cord-010092-uftc8inx 5753 11 ferritin ferritin NN cord-010092-uftc8inx 5753 12 levels level NNS cord-010092-uftc8inx 5753 13 in in IN cord-010092-uftc8inx 5753 14 regular regular JJ cord-010092-uftc8inx 5753 15 blood blood NN cord-010092-uftc8inx 5753 16 donors donor NNS cord-010092-uftc8inx 5753 17 . . . cord-010092-uftc8inx 5754 1 Methods method NNS cord-010092-uftc8inx 5754 2 : : : cord-010092-uftc8inx 5755 1 All all DT cord-010092-uftc8inx 5755 2 prospective prospective JJ cord-010092-uftc8inx 5755 3 donors donor NNS cord-010092-uftc8inx 5755 4 have have VBP cord-010092-uftc8inx 5755 5 been be VBN cord-010092-uftc8inx 5755 6 submitted submit VBN cord-010092-uftc8inx 5755 7 to to IN cord-010092-uftc8inx 5755 8 a a DT cord-010092-uftc8inx 5755 9 physical physical JJ cord-010092-uftc8inx 5755 10 examination examination NN cord-010092-uftc8inx 5755 11 and and CC cord-010092-uftc8inx 5755 12 a a DT cord-010092-uftc8inx 5755 13 health health NN cord-010092-uftc8inx 5755 14 history history NN cord-010092-uftc8inx 5755 15 assessment assessment NN cord-010092-uftc8inx 5755 16 intended intend VBN cord-010092-uftc8inx 5755 17 to to TO cord-010092-uftc8inx 5755 18 ensure ensure VB cord-010092-uftc8inx 5755 19 that that IN cord-010092-uftc8inx 5755 20 the the DT cord-010092-uftc8inx 5755 21 prospective prospective JJ cord-010092-uftc8inx 5755 22 donor donor NN cord-010092-uftc8inx 5755 23 is be VBZ cord-010092-uftc8inx 5755 24 in in IN cord-010092-uftc8inx 5755 25 a a DT cord-010092-uftc8inx 5755 26 good good JJ cord-010092-uftc8inx 5755 27 general general JJ cord-010092-uftc8inx 5755 28 health health NN cord-010092-uftc8inx 5755 29 and and CC cord-010092-uftc8inx 5755 30 eligible eligible JJ cord-010092-uftc8inx 5755 31 to to TO cord-010092-uftc8inx 5755 32 donate donate VB cord-010092-uftc8inx 5755 33 blood blood NN cord-010092-uftc8inx 5755 34 . . . cord-010092-uftc8inx 5756 1 The the DT cord-010092-uftc8inx 5756 2 acceptance acceptance NN cord-010092-uftc8inx 5756 3 criteria criterion NNS cord-010092-uftc8inx 5756 4 are be VBP cord-010092-uftc8inx 5756 5 : : : cord-010092-uftc8inx 5756 6 • • . cord-010092-uftc8inx 5757 1 Hemoglobin hemoglobin NN cord-010092-uftc8inx 5757 2 > > NFP cord-010092-uftc8inx 5757 3 or or CC cord-010092-uftc8inx 5757 4 = = SYM cord-010092-uftc8inx 5757 5 13.5 13.5 CD cord-010092-uftc8inx 5757 6 g g NN cord-010092-uftc8inx 5757 7 / / SYM cord-010092-uftc8inx 5757 8 dl dl NNP cord-010092-uftc8inx 5757 9 for for IN cord-010092-uftc8inx 5757 10 male male NN cord-010092-uftc8inx 5757 11 and and CC cord-010092-uftc8inx 5757 12 > > XX cord-010092-uftc8inx 5757 13 or or CC cord-010092-uftc8inx 5757 14 = = SYM cord-010092-uftc8inx 5757 15 12.5 12.5 CD cord-010092-uftc8inx 5757 16 g g NN cord-010092-uftc8inx 5757 17 / / SYM cord-010092-uftc8inx 5757 18 dl dl NN cord-010092-uftc8inx 5757 19 for for IN cord-010092-uftc8inx 5757 20 female female NN cord-010092-uftc8inx 5758 1 • • NNP cord-010092-uftc8inx 5759 1 Inter Inter NNP cord-010092-uftc8inx 5759 2 donation donation NN cord-010092-uftc8inx 5759 3 interval interval NN cord-010092-uftc8inx 5759 4 = = NFP cord-010092-uftc8inx 5760 1 56 56 CD cord-010092-uftc8inx 5760 2 days day NNS cord-010092-uftc8inx 5760 3 • • NNS cord-010092-uftc8inx 5760 4 5 5 CD cord-010092-uftc8inx 5760 5 donations donation NNS cord-010092-uftc8inx 5760 6 / / SYM cord-010092-uftc8inx 5760 7 year year NN cord-010092-uftc8inx 5760 8 for for IN cord-010092-uftc8inx 5760 9 male male NN cord-010092-uftc8inx 5760 10 and and CC cord-010092-uftc8inx 5760 11 3 3 CD cord-010092-uftc8inx 5760 12 / / SYM cord-010092-uftc8inx 5760 13 year year NN cord-010092-uftc8inx 5760 14 for for IN cord-010092-uftc8inx 5760 15 female female JJ cord-010092-uftc8inx 5760 16 All all DT cord-010092-uftc8inx 5760 17 eligible eligible JJ cord-010092-uftc8inx 5760 18 donors donor NNS cord-010092-uftc8inx 5760 19 and and CC cord-010092-uftc8inx 5760 20 deferred deferred JJ cord-010092-uftc8inx 5760 21 donors donor NNS cord-010092-uftc8inx 5760 22 for for IN cord-010092-uftc8inx 5760 23 all all DT cord-010092-uftc8inx 5760 24 reasons reason NNS cord-010092-uftc8inx 5760 25 except except IN cord-010092-uftc8inx 5760 26 for for IN cord-010092-uftc8inx 5760 27 low low JJ cord-010092-uftc8inx 5760 28 hemoglobin hemoglobin NN cord-010092-uftc8inx 5760 29 who who WP cord-010092-uftc8inx 5760 30 accepted accept VBD cord-010092-uftc8inx 5760 31 to to TO cord-010092-uftc8inx 5760 32 enroll enroll VB cord-010092-uftc8inx 5760 33 in in IN cord-010092-uftc8inx 5760 34 this this DT cord-010092-uftc8inx 5760 35 study study NN cord-010092-uftc8inx 5760 36 and and CC cord-010092-uftc8inx 5760 37 signed sign VBD cord-010092-uftc8inx 5760 38 a a DT cord-010092-uftc8inx 5760 39 consent consent NN cord-010092-uftc8inx 5760 40 . . . cord-010092-uftc8inx 5761 1 In in IN cord-010092-uftc8inx 5761 2 addition addition NN cord-010092-uftc8inx 5761 3 to to IN cord-010092-uftc8inx 5761 4 the the DT cord-010092-uftc8inx 5761 5 medical medical JJ cord-010092-uftc8inx 5761 6 exam exam NN cord-010092-uftc8inx 5761 7 , , , cord-010092-uftc8inx 5761 8 two two CD cord-010092-uftc8inx 5761 9 samples sample NNS cord-010092-uftc8inx 5761 10 have have VBP cord-010092-uftc8inx 5761 11 been be VBN cord-010092-uftc8inx 5761 12 collected collect VBN cord-010092-uftc8inx 5761 13 one one CD cord-010092-uftc8inx 5761 14 for for IN cord-010092-uftc8inx 5761 15 CBC CBC NNP cord-010092-uftc8inx 5761 16 and and CC cord-010092-uftc8inx 5761 17 another another DT cord-010092-uftc8inx 5761 18 for for IN cord-010092-uftc8inx 5761 19 Ferritin ferritin NN cord-010092-uftc8inx 5761 20 . . . cord-010092-uftc8inx 5762 1 Donation donation NN cord-010092-uftc8inx 5762 2 history history NN cord-010092-uftc8inx 5762 3 , , , cord-010092-uftc8inx 5762 4 sex sex NN cord-010092-uftc8inx 5762 5 , , , cord-010092-uftc8inx 5762 6 age age NN cord-010092-uftc8inx 5762 7 and and CC cord-010092-uftc8inx 5762 8 weight weight NN cord-010092-uftc8inx 5762 9 have have VBP cord-010092-uftc8inx 5762 10 been be VBN cord-010092-uftc8inx 5762 11 documented document VBN cord-010092-uftc8inx 5762 12 . . . cord-010092-uftc8inx 5763 1 Results result NNS cord-010092-uftc8inx 5763 2 : : : cord-010092-uftc8inx 5764 1 1056 1056 CD cord-010092-uftc8inx 5764 2 first first JJ cord-010092-uftc8inx 5764 3 time time NN cord-010092-uftc8inx 5764 4 and and CC cord-010092-uftc8inx 5764 5 regular regular JJ cord-010092-uftc8inx 5764 6 donors donor NNS cord-010092-uftc8inx 5764 7 accepted accept VBN cord-010092-uftc8inx 5764 8 to to TO cord-010092-uftc8inx 5764 9 enroll enroll VB cord-010092-uftc8inx 5764 10 in in IN cord-010092-uftc8inx 5764 11 this this DT cord-010092-uftc8inx 5764 12 study study NN cord-010092-uftc8inx 5764 13 . . . cord-010092-uftc8inx 5765 1 Only only RB cord-010092-uftc8inx 5765 2 38 38 CD cord-010092-uftc8inx 5765 3 female female JJ cord-010092-uftc8inx 5765 4 donors donor NNS cord-010092-uftc8inx 5765 5 ( ( -LRB- cord-010092-uftc8inx 5765 6 3.6 3.6 CD cord-010092-uftc8inx 5765 7 % % NN cord-010092-uftc8inx 5765 8 ) ) -RRB- cord-010092-uftc8inx 5765 9 participated participate VBD cord-010092-uftc8inx 5765 10 to to IN cord-010092-uftc8inx 5765 11 this this DT cord-010092-uftc8inx 5765 12 study study NN cord-010092-uftc8inx 5765 13 . . . cord-010092-uftc8inx 5766 1 11.3 11.3 CD cord-010092-uftc8inx 5766 2 % % NN cord-010092-uftc8inx 5766 3 of of IN cord-010092-uftc8inx 5766 4 the the DT cord-010092-uftc8inx 5766 5 participants participant NNS cord-010092-uftc8inx 5766 6 were be VBD cord-010092-uftc8inx 5766 7 first first JJ cord-010092-uftc8inx 5766 8 time time NN cord-010092-uftc8inx 5766 9 donor donor NN cord-010092-uftc8inx 5766 10 . . . cord-010092-uftc8inx 5767 1 21 21 CD cord-010092-uftc8inx 5767 2 % % NN cord-010092-uftc8inx 5767 3 of of IN cord-010092-uftc8inx 5767 4 male male NN cord-010092-uftc8inx 5767 5 and and CC cord-010092-uftc8inx 5767 6 26 26 CD cord-010092-uftc8inx 5767 7 % % NN cord-010092-uftc8inx 5767 8 of of IN cord-010092-uftc8inx 5767 9 female female JJ cord-010092-uftc8inx 5767 10 frequent frequent JJ cord-010092-uftc8inx 5767 11 donors donor NNS cord-010092-uftc8inx 5767 12 are be VBP cord-010092-uftc8inx 5767 13 iron iron NN cord-010092-uftc8inx 5767 14 deficient deficient JJ cord-010092-uftc8inx 5767 15 173 173 CD cord-010092-uftc8inx 5767 16 out out IN cord-010092-uftc8inx 5767 17 of of IN cord-010092-uftc8inx 5767 18 1018 1018 CD cord-010092-uftc8inx 5767 19 male male JJ cord-010092-uftc8inx 5767 20 blood blood NN cord-010092-uftc8inx 5767 21 donors donor NNS cord-010092-uftc8inx 5767 22 were be VBD cord-010092-uftc8inx 5767 23 iron iron NN cord-010092-uftc8inx 5767 24 deficient deficient JJ cord-010092-uftc8inx 5767 25 ( ( -LRB- cord-010092-uftc8inx 5767 26 17 17 CD cord-010092-uftc8inx 5767 27 % % NN cord-010092-uftc8inx 5767 28 ) ) -RRB- cord-010092-uftc8inx 5767 29 with with IN cord-010092-uftc8inx 5767 30 serum serum NN cord-010092-uftc8inx 5767 31 ferritin ferritin NN cord-010092-uftc8inx 5767 32 < < XX cord-010092-uftc8inx 5767 33 30 30 CD cord-010092-uftc8inx 5768 1 ng ng NNP cord-010092-uftc8inx 5768 2 / / SYM cord-010092-uftc8inx 5768 3 ml ml NN cord-010092-uftc8inx 5768 4 . . . cord-010092-uftc8inx 5769 1 98.8 98.8 CD cord-010092-uftc8inx 5769 2 % % NN cord-010092-uftc8inx 5769 3 were be VBD cord-010092-uftc8inx 5769 4 repeat repeat NN cord-010092-uftc8inx 5769 5 donors donor NNS cord-010092-uftc8inx 5769 6 . . . cord-010092-uftc8inx 5770 1 7 7 CD cord-010092-uftc8inx 5770 2 out out IN cord-010092-uftc8inx 5770 3 of of IN cord-010092-uftc8inx 5770 4 38 38 CD cord-010092-uftc8inx 5770 5 female female JJ cord-010092-uftc8inx 5770 6 donors donor NNS cord-010092-uftc8inx 5770 7 were be VBD cord-010092-uftc8inx 5770 8 iron iron NN cord-010092-uftc8inx 5770 9 deficient deficient JJ cord-010092-uftc8inx 5770 10 ( ( -LRB- cord-010092-uftc8inx 5770 11 18.4 18.4 CD cord-010092-uftc8inx 5770 12 % % NN cord-010092-uftc8inx 5770 13 ) ) -RRB- cord-010092-uftc8inx 5770 14 with with IN cord-010092-uftc8inx 5770 15 serum serum NN cord-010092-uftc8inx 5770 16 ferritin ferritin NN cord-010092-uftc8inx 5771 1 < < NNP cord-010092-uftc8inx 5771 2 13 13 CD cord-010092-uftc8inx 5771 3 ng/ ng/ NNP cord-010092-uftc8inx 5771 4 ml ml NNP cord-010092-uftc8inx 5771 5 , , , cord-010092-uftc8inx 5771 6 all all DT cord-010092-uftc8inx 5771 7 were be VBD cord-010092-uftc8inx 5771 8 repeat repeat NN cord-010092-uftc8inx 5771 9 donors donor NNS cord-010092-uftc8inx 5771 10 . . . cord-010092-uftc8inx 5772 1 19.2 19.2 CD cord-010092-uftc8inx 5772 2 % % NN cord-010092-uftc8inx 5772 3 of of IN cord-010092-uftc8inx 5772 4 repeat repeat NN cord-010092-uftc8inx 5772 5 donors donor NNS cord-010092-uftc8inx 5772 6 were be VBD cord-010092-uftc8inx 5772 7 iron iron NN cord-010092-uftc8inx 5772 8 deficient deficient JJ cord-010092-uftc8inx 5772 9 3/180 3/180 CD cord-010092-uftc8inx 5772 10 of of IN cord-010092-uftc8inx 5772 11 the the DT cord-010092-uftc8inx 5772 12 deplete deplete JJ cord-010092-uftc8inx 5772 13 donors donor NNS cord-010092-uftc8inx 5772 14 were be VBD cord-010092-uftc8inx 5772 15 first first JJ cord-010092-uftc8inx 5772 16 time time NN cord-010092-uftc8inx 5772 17 donors donor NNS cord-010092-uftc8inx 5772 18 Summary Summary NNP cord-010092-uftc8inx 5772 19 / / SYM cord-010092-uftc8inx 5772 20 Conclusions Conclusions NNPS cord-010092-uftc8inx 5772 21 : : : cord-010092-uftc8inx 5773 1 Frequent frequent JJ cord-010092-uftc8inx 5773 2 blood blood NN cord-010092-uftc8inx 5773 3 donors donor NNS cord-010092-uftc8inx 5773 4 have have VBP cord-010092-uftc8inx 5773 5 higher high JJR cord-010092-uftc8inx 5773 6 prevalence prevalence NN cord-010092-uftc8inx 5773 7 of of IN cord-010092-uftc8inx 5773 8 iron iron NN cord-010092-uftc8inx 5773 9 deficiency deficiency NN cord-010092-uftc8inx 5773 10 than than IN cord-010092-uftc8inx 5773 11 first first JJ cord-010092-uftc8inx 5773 12 time time NN cord-010092-uftc8inx 5773 13 donors donor NNS cord-010092-uftc8inx 5773 14 . . . cord-010092-uftc8inx 5774 1 Female female JJ cord-010092-uftc8inx 5774 2 donors donor NNS cord-010092-uftc8inx 5774 3 have have VBP cord-010092-uftc8inx 5774 4 a a DT cord-010092-uftc8inx 5774 5 slightly slightly RB cord-010092-uftc8inx 5774 6 higher high JJR cord-010092-uftc8inx 5774 7 prevalence prevalence NN cord-010092-uftc8inx 5774 8 of of IN cord-010092-uftc8inx 5774 9 iron iron NN cord-010092-uftc8inx 5774 10 deficiency deficiency NN cord-010092-uftc8inx 5774 11 than than IN cord-010092-uftc8inx 5774 12 male male JJ cord-010092-uftc8inx 5774 13 donors donor NNS cord-010092-uftc8inx 5774 14 . . . cord-010092-uftc8inx 5775 1 Prevalence prevalence NN cord-010092-uftc8inx 5775 2 of of IN cord-010092-uftc8inx 5775 3 iron iron NN cord-010092-uftc8inx 5775 4 deficiency deficiency NN cord-010092-uftc8inx 5775 5 in in IN cord-010092-uftc8inx 5775 6 Abu Abu NNP cord-010092-uftc8inx 5775 7 Dhabi Dhabi NNP cord-010092-uftc8inx 5775 8 donor donor NN cord-010092-uftc8inx 5775 9 population population NN cord-010092-uftc8inx 5775 10 is be VBZ cord-010092-uftc8inx 5775 11 lower low JJR cord-010092-uftc8inx 5775 12 than than IN cord-010092-uftc8inx 5775 13 the the DT cord-010092-uftc8inx 5775 14 published publish VBN cord-010092-uftc8inx 5775 15 data datum NNS cord-010092-uftc8inx 5775 16 . . . cord-010092-uftc8inx 5776 1 Changes change NNS cord-010092-uftc8inx 5776 2 need need VBP cord-010092-uftc8inx 5776 3 to to TO cord-010092-uftc8inx 5776 4 be be VB cord-010092-uftc8inx 5776 5 done do VBN cord-010092-uftc8inx 5776 6 on on IN cord-010092-uftc8inx 5776 7 : : : cord-010092-uftc8inx 5777 1 Increase increase VB cord-010092-uftc8inx 5777 2 inter inter JJ cord-010092-uftc8inx 5777 3 donation donation NN cord-010092-uftc8inx 5777 4 interval interval NN cord-010092-uftc8inx 5777 5 OR or CC cord-010092-uftc8inx 5777 6 restrict restrict VB cord-010092-uftc8inx 5777 7 the the DT cord-010092-uftc8inx 5777 8 total total JJ cord-010092-uftc8inx 5777 9 number number NN cord-010092-uftc8inx 5777 10 of of IN cord-010092-uftc8inx 5777 11 allowable allowable JJ cord-010092-uftc8inx 5777 12 donations donation NNS cord-010092-uftc8inx 5777 13 in in IN cord-010092-uftc8inx 5777 14 a a DT cord-010092-uftc8inx 5777 15 12-month 12-month JJ cord-010092-uftc8inx 5777 16 period period NN cord-010092-uftc8inx 5777 17 for for IN cord-010092-uftc8inx 5777 18 whole whole JJ cord-010092-uftc8inx 5777 19 blood blood NN cord-010092-uftc8inx 5777 20 and and CC cord-010092-uftc8inx 5777 21 red red JJ cord-010092-uftc8inx 5777 22 cells cell NNS cord-010092-uftc8inx 5777 23 Modifying modify VBG cord-010092-uftc8inx 5777 24 donor donor NN cord-010092-uftc8inx 5777 25 Hemoglobin hemoglobin NN cord-010092-uftc8inx 5777 26 requirements requirement NNS cord-010092-uftc8inx 5777 27 Testing test VBG cord-010092-uftc8inx 5777 28 for for IN cord-010092-uftc8inx 5777 29 serum serum NN cord-010092-uftc8inx 5777 30 ferritin ferritin NN cord-010092-uftc8inx 5778 1 Iron iron NN cord-010092-uftc8inx 5778 2 supplementation supplementation NN cord-010092-uftc8inx 5778 3 Donor Donor NNP cord-010092-uftc8inx 5778 4 education education NN cord-010092-uftc8inx 5778 5 Abstract Abstract NNP cord-010092-uftc8inx 5778 6 withdrawn withdraw VBD cord-010092-uftc8inx 5778 7 . . . cord-010092-uftc8inx 5779 1 Background background NN cord-010092-uftc8inx 5779 2 : : : cord-010092-uftc8inx 5780 1 Haemovigilance Haemovigilance NNP cord-010092-uftc8inx 5780 2 procedures procedure NNS cord-010092-uftc8inx 5780 3 aim aim VBP cord-010092-uftc8inx 5780 4 to to TO cord-010092-uftc8inx 5780 5 guarantee guarantee VB cord-010092-uftc8inx 5780 6 not not RB cord-010092-uftc8inx 5780 7 only only RB cord-010092-uftc8inx 5780 8 the the DT cord-010092-uftc8inx 5780 9 safety safety NN cord-010092-uftc8inx 5780 10 of of IN cord-010092-uftc8inx 5780 11 the the DT cord-010092-uftc8inx 5780 12 recipients recipient NNS cord-010092-uftc8inx 5780 13 of of IN cord-010092-uftc8inx 5780 14 blood blood NN cord-010092-uftc8inx 5780 15 and and CC cord-010092-uftc8inx 5780 16 its -PRON- PRP$ cord-010092-uftc8inx 5780 17 components component NNS cord-010092-uftc8inx 5780 18 but but CC cord-010092-uftc8inx 5780 19 the the DT cord-010092-uftc8inx 5780 20 safety safety NN cord-010092-uftc8inx 5780 21 of of IN cord-010092-uftc8inx 5780 22 the the DT cord-010092-uftc8inx 5780 23 donors donor NNS cord-010092-uftc8inx 5780 24 as as RB cord-010092-uftc8inx 5780 25 well well RB cord-010092-uftc8inx 5780 26 . . . cord-010092-uftc8inx 5781 1 Every every DT cord-010092-uftc8inx 5781 2 adverse adverse JJ cord-010092-uftc8inx 5781 3 reaction reaction NN cord-010092-uftc8inx 5781 4 that that WDT cord-010092-uftc8inx 5781 5 occurs occur VBZ cord-010092-uftc8inx 5781 6 during during IN cord-010092-uftc8inx 5781 7 the the DT cord-010092-uftc8inx 5781 8 donation donation NN cord-010092-uftc8inx 5781 9 of of IN cord-010092-uftc8inx 5781 10 blood blood NN cord-010092-uftc8inx 5781 11 or or CC cord-010092-uftc8inx 5781 12 its -PRON- PRP$ cord-010092-uftc8inx 5781 13 components component NNS cord-010092-uftc8inx 5781 14 can can MD cord-010092-uftc8inx 5781 15 potentially potentially RB cord-010092-uftc8inx 5781 16 be be VB cord-010092-uftc8inx 5781 17 a a DT cord-010092-uftc8inx 5781 18 threat threat NN cord-010092-uftc8inx 5781 19 to to IN cord-010092-uftc8inx 5781 20 the the DT cord-010092-uftc8inx 5781 21 health health NN cord-010092-uftc8inx 5781 22 of of IN cord-010092-uftc8inx 5781 23 the the DT cord-010092-uftc8inx 5781 24 donor donor NN cord-010092-uftc8inx 5781 25 which which WDT cord-010092-uftc8inx 5781 26 can can MD cord-010092-uftc8inx 5781 27 subsequently subsequently RB cord-010092-uftc8inx 5781 28 lead lead VB cord-010092-uftc8inx 5781 29 to to IN cord-010092-uftc8inx 5781 30 the the DT cord-010092-uftc8inx 5781 31 decision decision NN cord-010092-uftc8inx 5781 32 of of IN cord-010092-uftc8inx 5781 33 the the DT cord-010092-uftc8inx 5781 34 donor donor NN cord-010092-uftc8inx 5781 35 to to TO cord-010092-uftc8inx 5781 36 resign resign VB cord-010092-uftc8inx 5781 37 from from IN cord-010092-uftc8inx 5781 38 donating donate VBG cord-010092-uftc8inx 5781 39 blood blood NN cord-010092-uftc8inx 5781 40 . . . cord-010092-uftc8inx 5782 1 Aims aim VBZ cord-010092-uftc8inx 5782 2 : : : cord-010092-uftc8inx 5783 1 The the DT cord-010092-uftc8inx 5783 2 aim aim NN cord-010092-uftc8inx 5783 3 is be VBZ cord-010092-uftc8inx 5783 4 to to TO cord-010092-uftc8inx 5783 5 analyse analyse VB cord-010092-uftc8inx 5783 6 the the DT cord-010092-uftc8inx 5783 7 type type NN cord-010092-uftc8inx 5783 8 and and CC cord-010092-uftc8inx 5783 9 the the DT cord-010092-uftc8inx 5783 10 frequency frequency NN cord-010092-uftc8inx 5783 11 of of IN cord-010092-uftc8inx 5783 12 occurrence occurrence NN cord-010092-uftc8inx 5783 13 of of IN cord-010092-uftc8inx 5783 14 adverse adverse JJ cord-010092-uftc8inx 5783 15 reactions reaction NNS cord-010092-uftc8inx 5783 16 among among IN cord-010092-uftc8inx 5783 17 the the DT cord-010092-uftc8inx 5783 18 donors donor NNS cord-010092-uftc8inx 5783 19 donating donate VBG cord-010092-uftc8inx 5783 20 blood blood NN cord-010092-uftc8inx 5783 21 or or CC cord-010092-uftc8inx 5783 22 its -PRON- PRP$ cord-010092-uftc8inx 5783 23 components component NNS cord-010092-uftc8inx 5783 24 independently independently RB cord-010092-uftc8inx 5783 25 of of IN cord-010092-uftc8inx 5783 26 the the DT cord-010092-uftc8inx 5783 27 method method NN cord-010092-uftc8inx 5783 28 of of IN cord-010092-uftc8inx 5783 29 the the DT cord-010092-uftc8inx 5783 30 donation donation NN cord-010092-uftc8inx 5783 31 . . . cord-010092-uftc8inx 5784 1 Methods method NNS cord-010092-uftc8inx 5784 2 : : : cord-010092-uftc8inx 5784 3 We -PRON- PRP cord-010092-uftc8inx 5784 4 have have VBP cord-010092-uftc8inx 5784 5 analysed analyse VBN cord-010092-uftc8inx 5784 6 the the DT cord-010092-uftc8inx 5784 7 number number NN cord-010092-uftc8inx 5784 8 of of IN cord-010092-uftc8inx 5784 9 collected collect VBN cord-010092-uftc8inx 5784 10 donations donation NNS cord-010092-uftc8inx 5784 11 and and CC cord-010092-uftc8inx 5784 12 the the DT cord-010092-uftc8inx 5784 13 number number NN cord-010092-uftc8inx 5784 14 of of IN cord-010092-uftc8inx 5784 15 adverse adverse JJ cord-010092-uftc8inx 5784 16 reactions reaction NNS cord-010092-uftc8inx 5784 17 in in IN cord-010092-uftc8inx 5784 18 the the DT cord-010092-uftc8inx 5784 19 years year NNS cord-010092-uftc8inx 5784 20 2014 2014 CD cord-010092-uftc8inx 5784 21 - - SYM cord-010092-uftc8inx 5784 22 2018 2018 CD cord-010092-uftc8inx 5784 23 in in IN cord-010092-uftc8inx 5784 24 the the DT cord-010092-uftc8inx 5784 25 group group NN cord-010092-uftc8inx 5784 26 donors donor NNS cord-010092-uftc8inx 5784 27 of of IN cord-010092-uftc8inx 5784 28 aged aged JJ cord-010092-uftc8inx 5784 29 18 18 CD cord-010092-uftc8inx 5784 30 - - SYM cord-010092-uftc8inx 5784 31 24 24 CD cord-010092-uftc8inx 5784 32 . . . cord-010092-uftc8inx 5785 1 We -PRON- PRP cord-010092-uftc8inx 5785 2 have have VBP cord-010092-uftc8inx 5785 3 specified specify VBN cord-010092-uftc8inx 5785 4 following follow VBG cord-010092-uftc8inx 5785 5 adverse adverse JJ cord-010092-uftc8inx 5785 6 reactions reaction NNS cord-010092-uftc8inx 5785 7 : : : cord-010092-uftc8inx 5785 8 vasovagal vasovagal JJ cord-010092-uftc8inx 5785 9 response response NN cord-010092-uftc8inx 5785 10 without without IN cord-010092-uftc8inx 5785 11 fainting faint VBG cord-010092-uftc8inx 5785 12 , , , cord-010092-uftc8inx 5785 13 vasovagal vasovagal JJ cord-010092-uftc8inx 5785 14 response response NN cord-010092-uftc8inx 5785 15 with with IN cord-010092-uftc8inx 5785 16 fainting fainting NN cord-010092-uftc8inx 5785 17 , , , cord-010092-uftc8inx 5785 18 vascular vascular JJ cord-010092-uftc8inx 5785 19 reactions reaction NNS cord-010092-uftc8inx 5785 20 ( ( -LRB- cord-010092-uftc8inx 5785 21 bruises bruise NNS cord-010092-uftc8inx 5785 22 ) ) -RRB- cord-010092-uftc8inx 5785 23 and and CC cord-010092-uftc8inx 5785 24 other other JJ cord-010092-uftc8inx 5785 25 ( ( -LRB- cord-010092-uftc8inx 5785 26 e.g. e.g. RB cord-010092-uftc8inx 5785 27 allergic allergic JJ cord-010092-uftc8inx 5785 28 reaction reaction NN cord-010092-uftc8inx 5785 29 to to IN cord-010092-uftc8inx 5785 30 the the DT cord-010092-uftc8inx 5785 31 anticoagulant anticoagulant NN cord-010092-uftc8inx 5785 32 , , , cord-010092-uftc8inx 5785 33 loss loss NN cord-010092-uftc8inx 5785 34 of of IN cord-010092-uftc8inx 5785 35 blood blood NN cord-010092-uftc8inx 5785 36 pressure pressure NN cord-010092-uftc8inx 5785 37 due due IN cord-010092-uftc8inx 5785 38 to to IN cord-010092-uftc8inx 5785 39 hypovolemia hypovolemia NN cord-010092-uftc8inx 5785 40 ) ) -RRB- cord-010092-uftc8inx 5785 41 . . . cord-010092-uftc8inx 5786 1 The the DT cord-010092-uftc8inx 5786 2 analysis analysis NN cord-010092-uftc8inx 5786 3 was be VBD cord-010092-uftc8inx 5786 4 made make VBN cord-010092-uftc8inx 5786 5 using use VBG cord-010092-uftc8inx 5786 6 data datum NNS cord-010092-uftc8inx 5786 7 obtained obtain VBN cord-010092-uftc8inx 5786 8 from from IN cord-010092-uftc8inx 5786 9 computer computer NN cord-010092-uftc8inx 5786 10 system system NN cord-010092-uftc8inx 5786 11 Blood Blood NNP cord-010092-uftc8inx 5786 12 Bank Bank NNP cord-010092-uftc8inx 5786 13 which which WDT cord-010092-uftc8inx 5786 14 is be VBZ cord-010092-uftc8inx 5786 15 in in IN cord-010092-uftc8inx 5786 16 operation operation NN cord-010092-uftc8inx 5786 17 in in IN cord-010092-uftc8inx 5786 18 Blood Blood NNP cord-010092-uftc8inx 5786 19 Center Center NNP cord-010092-uftc8inx 5786 20 in in IN cord-010092-uftc8inx 5786 21 Pozna Pozna NNP cord-010092-uftc8inx 5786 22 n n NNP cord-010092-uftc8inx 5786 23 , , , cord-010092-uftc8inx 5786 24 Poland Poland NNP cord-010092-uftc8inx 5786 25 . . . cord-010092-uftc8inx 5787 1 Results result NNS cord-010092-uftc8inx 5787 2 : : : cord-010092-uftc8inx 5788 1 In in IN cord-010092-uftc8inx 5788 2 years year NNS cord-010092-uftc8inx 5788 3 2014 2014 CD cord-010092-uftc8inx 5788 4 - - SYM cord-010092-uftc8inx 5788 5 2018 2018 CD cord-010092-uftc8inx 5788 6 the the DT cord-010092-uftc8inx 5788 7 total total JJ cord-010092-uftc8inx 5788 8 number number NN cord-010092-uftc8inx 5788 9 of of IN cord-010092-uftc8inx 5788 10 1904 1904 CD cord-010092-uftc8inx 5788 11 adverse adverse JJ cord-010092-uftc8inx 5788 12 reactions reaction NNS cord-010092-uftc8inx 5788 13 among among IN cord-010092-uftc8inx 5788 14 the the DT cord-010092-uftc8inx 5788 15 donors donor NNS cord-010092-uftc8inx 5788 16 was be VBD cord-010092-uftc8inx 5788 17 recorded record VBN cord-010092-uftc8inx 5788 18 which which WDT cord-010092-uftc8inx 5788 19 is be VBZ cord-010092-uftc8inx 5788 20 0.39 0.39 CD cord-010092-uftc8inx 5788 21 % % NN cord-010092-uftc8inx 5788 22 of of IN cord-010092-uftc8inx 5788 23 the the DT cord-010092-uftc8inx 5788 24 total total JJ cord-010092-uftc8inx 5788 25 number number NN cord-010092-uftc8inx 5788 26 of of IN cord-010092-uftc8inx 5788 27 collected collect VBN cord-010092-uftc8inx 5788 28 donations donation NNS cord-010092-uftc8inx 5788 29 . . . cord-010092-uftc8inx 5789 1 50 50 CD cord-010092-uftc8inx 5789 2 % % NN cord-010092-uftc8inx 5789 3 of of IN cord-010092-uftc8inx 5789 4 the the DT cord-010092-uftc8inx 5789 5 adverse adverse JJ cord-010092-uftc8inx 5789 6 reactions reaction NNS cord-010092-uftc8inx 5789 7 occurred occur VBD cord-010092-uftc8inx 5789 8 in in IN cord-010092-uftc8inx 5789 9 the the DT cord-010092-uftc8inx 5789 10 group group NN cord-010092-uftc8inx 5789 11 of of IN cord-010092-uftc8inx 5789 12 donors donor NNS cord-010092-uftc8inx 5789 13 aged age VBN cord-010092-uftc8inx 5789 14 18 18 CD cord-010092-uftc8inx 5789 15 - - SYM cord-010092-uftc8inx 5789 16 24 24 CD cord-010092-uftc8inx 5789 17 . . . cord-010092-uftc8inx 5790 1 Vasovagal vasovagal JJ cord-010092-uftc8inx 5790 2 response response NN cord-010092-uftc8inx 5790 3 without without IN cord-010092-uftc8inx 5790 4 fainting fainting NN cord-010092-uftc8inx 5790 5 was be VBD cord-010092-uftc8inx 5790 6 the the DT cord-010092-uftc8inx 5790 7 most most RBS cord-010092-uftc8inx 5790 8 common common JJ cord-010092-uftc8inx 5790 9 adverse adverse JJ cord-010092-uftc8inx 5790 10 reaction reaction NN cord-010092-uftc8inx 5790 11 in in IN cord-010092-uftc8inx 5790 12 the the DT cord-010092-uftc8inx 5790 13 total total JJ cord-010092-uftc8inx 5790 14 number number NN cord-010092-uftc8inx 5790 15 of of IN cord-010092-uftc8inx 5790 16 reactions reaction NNS cord-010092-uftc8inx 5790 17 and and CC cord-010092-uftc8inx 5790 18 totalled total VBD cord-010092-uftc8inx 5790 19 50.2 50.2 CD cord-010092-uftc8inx 5790 20 % % NN cord-010092-uftc8inx 5790 21 of of IN cord-010092-uftc8inx 5790 22 all all DT cord-010092-uftc8inx 5790 23 adverse adverse JJ cord-010092-uftc8inx 5790 24 reactions reaction NNS cord-010092-uftc8inx 5790 25 . . . cord-010092-uftc8inx 5791 1 In in IN cord-010092-uftc8inx 5791 2 the the DT cord-010092-uftc8inx 5791 3 group group NN cord-010092-uftc8inx 5791 4 of of IN cord-010092-uftc8inx 5791 5 donors donor NNS cord-010092-uftc8inx 5791 6 ages age NNS cord-010092-uftc8inx 5791 7 18 18 CD cord-010092-uftc8inx 5791 8 - - SYM cord-010092-uftc8inx 5791 9 24 24 CD cord-010092-uftc8inx 5791 10 it -PRON- PRP cord-010092-uftc8inx 5791 11 totalled total VBD cord-010092-uftc8inx 5791 12 27 27 CD cord-010092-uftc8inx 5791 13 % % NN cord-010092-uftc8inx 5791 14 of of IN cord-010092-uftc8inx 5791 15 all all DT cord-010092-uftc8inx 5791 16 adverse adverse JJ cord-010092-uftc8inx 5791 17 reactions reaction NNS cord-010092-uftc8inx 5791 18 . . . cord-010092-uftc8inx 5792 1 The the DT cord-010092-uftc8inx 5792 2 second second JJ cord-010092-uftc8inx 5792 3 most most RBS cord-010092-uftc8inx 5792 4 common common JJ cord-010092-uftc8inx 5792 5 type type NN cord-010092-uftc8inx 5792 6 of of IN cord-010092-uftc8inx 5792 7 adverse adverse JJ cord-010092-uftc8inx 5792 8 reactions reaction NNS cord-010092-uftc8inx 5792 9 was be VBD cord-010092-uftc8inx 5792 10 vasovagal vasovagal JJ cord-010092-uftc8inx 5792 11 syncope syncope NN cord-010092-uftc8inx 5792 12 that that WDT cord-010092-uftc8inx 5792 13 totalled total VBD cord-010092-uftc8inx 5792 14 29.8 29.8 CD cord-010092-uftc8inx 5792 15 % % NN cord-010092-uftc8inx 5792 16 , , , cord-010092-uftc8inx 5792 17 in in IN cord-010092-uftc8inx 5792 18 the the DT cord-010092-uftc8inx 5792 19 analysed analyse VBN cord-010092-uftc8inx 5792 20 group group NN cord-010092-uftc8inx 5792 21 of of IN cord-010092-uftc8inx 5792 22 donors donor NNS cord-010092-uftc8inx 5792 23 15.96 15.96 CD cord-010092-uftc8inx 5792 24 % % NN cord-010092-uftc8inx 5792 25 . . . cord-010092-uftc8inx 5793 1 Vascular vascular JJ cord-010092-uftc8inx 5793 2 reactions reaction NNS cord-010092-uftc8inx 5793 3 ( ( -LRB- cord-010092-uftc8inx 5793 4 bruises bruise NNS cord-010092-uftc8inx 5793 5 ) ) -RRB- cord-010092-uftc8inx 5793 6 totalled total VBD cord-010092-uftc8inx 5793 7 10.2 10.2 CD cord-010092-uftc8inx 5793 8 % % NN cord-010092-uftc8inx 5793 9 of of IN cord-010092-uftc8inx 5793 10 all all DT cord-010092-uftc8inx 5793 11 adverse adverse JJ cord-010092-uftc8inx 5793 12 reaction reaction NN cord-010092-uftc8inx 5793 13 , , , cord-010092-uftc8inx 5793 14 in in IN cord-010092-uftc8inx 5793 15 the the DT cord-010092-uftc8inx 5793 16 analysed analyse VBN cord-010092-uftc8inx 5793 17 group group NN cord-010092-uftc8inx 5793 18 5.6 5.6 CD cord-010092-uftc8inx 5793 19 % % NN cord-010092-uftc8inx 5793 20 . . . cord-010092-uftc8inx 5794 1 The the DT cord-010092-uftc8inx 5794 2 remaining remain VBG cord-010092-uftc8inx 5794 3 adverse adverse JJ cord-010092-uftc8inx 5794 4 reactions reaction NNS cord-010092-uftc8inx 5794 5 totalled total VBD cord-010092-uftc8inx 5794 6 9.8 9.8 CD cord-010092-uftc8inx 5794 7 % % NN cord-010092-uftc8inx 5794 8 . . . cord-010092-uftc8inx 5795 1 Summary Summary NNP cord-010092-uftc8inx 5795 2 / / SYM cord-010092-uftc8inx 5795 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 5795 4 : : : cord-010092-uftc8inx 5795 5 1 1 CD cord-010092-uftc8inx 5795 6 . . . cord-010092-uftc8inx 5796 1 Vasovagal vasovagal JJ cord-010092-uftc8inx 5796 2 reactions reaction NNS cord-010092-uftc8inx 5796 3 ( ( -LRB- cord-010092-uftc8inx 5796 4 with with IN cord-010092-uftc8inx 5796 5 and and CC cord-010092-uftc8inx 5796 6 without without IN cord-010092-uftc8inx 5796 7 fainting fainting NN cord-010092-uftc8inx 5796 8 ) ) -RRB- cord-010092-uftc8inx 5796 9 were be VBD cord-010092-uftc8inx 5796 10 proved prove VBN cord-010092-uftc8inx 5796 11 to to TO cord-010092-uftc8inx 5796 12 be be VB cord-010092-uftc8inx 5796 13 2 2 CD cord-010092-uftc8inx 5796 14 most most RBS cord-010092-uftc8inx 5796 15 common common JJ cord-010092-uftc8inx 5796 16 adverse adverse JJ cord-010092-uftc8inx 5796 17 reactions reaction NNS cord-010092-uftc8inx 5796 18 in in IN cord-010092-uftc8inx 5796 19 the the DT cord-010092-uftc8inx 5796 20 group group NN cord-010092-uftc8inx 5796 21 of of IN cord-010092-uftc8inx 5796 22 donors donor NNS cord-010092-uftc8inx 5796 23 aged age VBN cord-010092-uftc8inx 5796 24 18 18 CD cord-010092-uftc8inx 5796 25 - - SYM cord-010092-uftc8inx 5796 26 24 24 CD cord-010092-uftc8inx 5796 27 i.e. i.e. FW cord-010092-uftc8inx 5796 28 in in IN cord-010092-uftc8inx 5796 29 the the DT cord-010092-uftc8inx 5796 30 groups group NNS cord-010092-uftc8inx 5796 31 of of IN cord-010092-uftc8inx 5796 32 donors donor NNS cord-010092-uftc8inx 5796 33 just just RB cord-010092-uftc8inx 5796 34 starting start VBG cord-010092-uftc8inx 5796 35 to to TO cord-010092-uftc8inx 5796 36 donate donate VB cord-010092-uftc8inx 5796 37 blood blood NN cord-010092-uftc8inx 5796 38 . . . cord-010092-uftc8inx 5797 1 It -PRON- PRP cord-010092-uftc8inx 5797 2 seems seem VBZ cord-010092-uftc8inx 5797 3 reasonable reasonable JJ cord-010092-uftc8inx 5797 4 to to TO cord-010092-uftc8inx 5797 5 continue continue VB cord-010092-uftc8inx 5797 6 with with IN cord-010092-uftc8inx 5797 7 further further JJ cord-010092-uftc8inx 5797 8 research research NN cord-010092-uftc8inx 5797 9 into into IN cord-010092-uftc8inx 5797 10 the the DT cord-010092-uftc8inx 5797 11 reasons reason NNS cord-010092-uftc8inx 5797 12 for for IN cord-010092-uftc8inx 5797 13 the the DT cord-010092-uftc8inx 5797 14 occurrence occurrence NN cord-010092-uftc8inx 5797 15 of of IN cord-010092-uftc8inx 5797 16 this this DT cord-010092-uftc8inx 5797 17 psychosomatic psychosomatic JJ cord-010092-uftc8inx 5797 18 reactions reaction NNS cord-010092-uftc8inx 5797 19 . . . cord-010092-uftc8inx 5798 1 2 2 LS cord-010092-uftc8inx 5798 2 . . . cord-010092-uftc8inx 5799 1 It -PRON- PRP cord-010092-uftc8inx 5799 2 seems seem VBZ cord-010092-uftc8inx 5799 3 beneficial beneficial JJ cord-010092-uftc8inx 5799 4 to to TO cord-010092-uftc8inx 5799 5 provide provide VB cord-010092-uftc8inx 5799 6 constant constant JJ cord-010092-uftc8inx 5799 7 educational educational JJ cord-010092-uftc8inx 5799 8 activities activity NNS cord-010092-uftc8inx 5799 9 of of IN cord-010092-uftc8inx 5799 10 young young JJ cord-010092-uftc8inx 5799 11 donors donor NNS cord-010092-uftc8inx 5799 12 regarding regard VBG cord-010092-uftc8inx 5799 13 the the DT cord-010092-uftc8inx 5799 14 preparation preparation NN cord-010092-uftc8inx 5799 15 for for IN cord-010092-uftc8inx 5799 16 the the DT cord-010092-uftc8inx 5799 17 process process NN cord-010092-uftc8inx 5799 18 of of IN cord-010092-uftc8inx 5799 19 donation donation NN cord-010092-uftc8inx 5799 20 of of IN cord-010092-uftc8inx 5799 21 blood blood NN cord-010092-uftc8inx 5799 22 and and CC cord-010092-uftc8inx 5799 23 its -PRON- PRP$ cord-010092-uftc8inx 5799 24 components component NNS cord-010092-uftc8inx 5799 25 ( ( -LRB- cord-010092-uftc8inx 5799 26 proper proper JJ cord-010092-uftc8inx 5799 27 nourishment nourishment NN cord-010092-uftc8inx 5799 28 , , , cord-010092-uftc8inx 5799 29 hydration hydration NN cord-010092-uftc8inx 5799 30 as as RB cord-010092-uftc8inx 5799 31 well well RB cord-010092-uftc8inx 5799 32 as as IN cord-010092-uftc8inx 5799 33 planning plan VBG cord-010092-uftc8inx 5799 34 the the DT cord-010092-uftc8inx 5799 35 time time NN cord-010092-uftc8inx 5799 36 for for IN cord-010092-uftc8inx 5799 37 scheduled schedule VBN cord-010092-uftc8inx 5799 38 donation donation NN cord-010092-uftc8inx 5799 39 long long RB cord-010092-uftc8inx 5799 40 enough enough RB cord-010092-uftc8inx 5799 41 for for IN cord-010092-uftc8inx 5799 42 a a DT cord-010092-uftc8inx 5799 43 safe safe JJ cord-010092-uftc8inx 5799 44 and and CC cord-010092-uftc8inx 5799 45 pleasant pleasant JJ cord-010092-uftc8inx 5799 46 procedure procedure NN cord-010092-uftc8inx 5799 47 . . . cord-010092-uftc8inx 5800 1 3 3 LS cord-010092-uftc8inx 5800 2 . . . cord-010092-uftc8inx 5801 1 It -PRON- PRP cord-010092-uftc8inx 5801 2 seems seem VBZ cord-010092-uftc8inx 5801 3 beneficial beneficial JJ cord-010092-uftc8inx 5801 4 to to TO cord-010092-uftc8inx 5801 5 provide provide VB cord-010092-uftc8inx 5801 6 constant constant JJ cord-010092-uftc8inx 5801 7 training training NN cord-010092-uftc8inx 5801 8 for for IN cord-010092-uftc8inx 5801 9 the the DT cord-010092-uftc8inx 5801 10 medical medical JJ cord-010092-uftc8inx 5801 11 staff staff NN cord-010092-uftc8inx 5801 12 involved involve VBN cord-010092-uftc8inx 5801 13 in in IN cord-010092-uftc8inx 5801 14 the the DT cord-010092-uftc8inx 5801 15 process process NN cord-010092-uftc8inx 5801 16 of of IN cord-010092-uftc8inx 5801 17 donation donation NN cord-010092-uftc8inx 5801 18 regarding regard VBG cord-010092-uftc8inx 5801 19 active active JJ cord-010092-uftc8inx 5801 20 observation observation NN cord-010092-uftc8inx 5801 21 of of IN cord-010092-uftc8inx 5801 22 donors donor NNS cord-010092-uftc8inx 5801 23 , , , cord-010092-uftc8inx 5801 24 proper proper JJ cord-010092-uftc8inx 5801 25 conduct conduct NN cord-010092-uftc8inx 5801 26 in in IN cord-010092-uftc8inx 5801 27 the the DT cord-010092-uftc8inx 5801 28 situation situation NN cord-010092-uftc8inx 5801 29 when when WRB cord-010092-uftc8inx 5801 30 the the DT cord-010092-uftc8inx 5801 31 adverse adverse JJ cord-010092-uftc8inx 5801 32 reactions reaction NNS cord-010092-uftc8inx 5801 33 occur occur VBP cord-010092-uftc8inx 5801 34 during during IN cord-010092-uftc8inx 5801 35 the the DT cord-010092-uftc8inx 5801 36 blood blood NN cord-010092-uftc8inx 5801 37 donation donation NN cord-010092-uftc8inx 5801 38 , , , cord-010092-uftc8inx 5801 39 ways way NNS cord-010092-uftc8inx 5801 40 to to TO cord-010092-uftc8inx 5801 41 minimize minimize VB cord-010092-uftc8inx 5801 42 the the DT cord-010092-uftc8inx 5801 43 fear fear NN cord-010092-uftc8inx 5801 44 of of IN cord-010092-uftc8inx 5801 45 donors donor NNS cord-010092-uftc8inx 5801 46 , , , cord-010092-uftc8inx 5801 47 effective effective JJ cord-010092-uftc8inx 5801 48 communication communication NN cord-010092-uftc8inx 5801 49 with with IN cord-010092-uftc8inx 5801 50 the the DT cord-010092-uftc8inx 5801 51 donors donor NNS cord-010092-uftc8inx 5801 52 ( ( -LRB- cord-010092-uftc8inx 5801 53 explaining explain VBG cord-010092-uftc8inx 5801 54 the the DT cord-010092-uftc8inx 5801 55 process process NN cord-010092-uftc8inx 5801 56 of of IN cord-010092-uftc8inx 5801 57 blood blood NN cord-010092-uftc8inx 5801 58 donation donation NN cord-010092-uftc8inx 5801 59 , , , cord-010092-uftc8inx 5801 60 proper proper JJ cord-010092-uftc8inx 5801 61 behaviour behaviour NN cord-010092-uftc8inx 5801 62 after after IN cord-010092-uftc8inx 5801 63 the the DT cord-010092-uftc8inx 5801 64 donation donation NN cord-010092-uftc8inx 5801 65 e.g. e.g. RB cord-010092-uftc8inx 5801 66 avoiding avoid VBG cord-010092-uftc8inx 5801 67 physical physical JJ cord-010092-uftc8inx 5801 68 exercise exercise NN cord-010092-uftc8inx 5801 69 or or CC cord-010092-uftc8inx 5801 70 straining strain VBG cord-010092-uftc8inx 5801 71 the the DT cord-010092-uftc8inx 5801 72 arm arm NN cord-010092-uftc8inx 5801 73 ) ) -RRB- cord-010092-uftc8inx 5801 74 . . . cord-010092-uftc8inx 5802 1 Blood blood NN cord-010092-uftc8inx 5802 2 products product NNS cord-010092-uftc8inx 5802 3 -Blood -blood NN cord-010092-uftc8inx 5802 4 processing processing NN cord-010092-uftc8inx 5802 5 , , , cord-010092-uftc8inx 5802 6 storage storage NN cord-010092-uftc8inx 5802 7 and and CC cord-010092-uftc8inx 5802 8 release release NN cord-010092-uftc8inx 5802 9 Background background NN cord-010092-uftc8inx 5802 10 : : : cord-010092-uftc8inx 5803 1 The the DT cord-010092-uftc8inx 5803 2 accumulation accumulation NN cord-010092-uftc8inx 5803 3 of of IN cord-010092-uftc8inx 5803 4 microvesicles microvesicle NNS cord-010092-uftc8inx 5803 5 ( ( -LRB- cord-010092-uftc8inx 5803 6 MVs MVs NNPS cord-010092-uftc8inx 5803 7 ) ) -RRB- cord-010092-uftc8inx 5803 8 in in IN cord-010092-uftc8inx 5803 9 RBC RBC NNP cord-010092-uftc8inx 5803 10 concentrates concentrate VBZ cord-010092-uftc8inx 5803 11 during during IN cord-010092-uftc8inx 5803 12 storage storage NN cord-010092-uftc8inx 5803 13 may may MD cord-010092-uftc8inx 5803 14 be be VB cord-010092-uftc8inx 5803 15 responsible responsible JJ cord-010092-uftc8inx 5803 16 for for IN cord-010092-uftc8inx 5803 17 clinical clinical JJ cord-010092-uftc8inx 5803 18 symptoms symptom NNS cord-010092-uftc8inx 5803 19 such such JJ cord-010092-uftc8inx 5803 20 as as IN cord-010092-uftc8inx 5803 21 inflammation inflammation NN cord-010092-uftc8inx 5803 22 , , , cord-010092-uftc8inx 5803 23 coagulation coagulation NN cord-010092-uftc8inx 5803 24 , , , cord-010092-uftc8inx 5803 25 and and CC cord-010092-uftc8inx 5803 26 immunization immunization NN cord-010092-uftc8inx 5803 27 . . . cord-010092-uftc8inx 5804 1 Aims aim VBZ cord-010092-uftc8inx 5804 2 : : : cord-010092-uftc8inx 5805 1 Our -PRON- PRP$ cord-010092-uftc8inx 5805 2 aims aim NNS cord-010092-uftc8inx 5805 3 was be VBD cord-010092-uftc8inx 5805 4 to to TO cord-010092-uftc8inx 5805 5 determine determine VB cord-010092-uftc8inx 5805 6 whether whether IN cord-010092-uftc8inx 5805 7 any any DT cord-010092-uftc8inx 5805 8 of of IN cord-010092-uftc8inx 5805 9 CD cd NN cord-010092-uftc8inx 5805 10 molecules molecule NNS cord-010092-uftc8inx 5805 11 responsible responsible JJ cord-010092-uftc8inx 5805 12 for for IN cord-010092-uftc8inx 5805 13 important important JJ cord-010092-uftc8inx 5805 14 functions function NNS cord-010092-uftc8inx 5805 15 are be VBP cord-010092-uftc8inx 5805 16 present present JJ cord-010092-uftc8inx 5805 17 on on IN cord-010092-uftc8inx 5805 18 the the DT cord-010092-uftc8inx 5805 19 microvesicles microvesicle NNS cord-010092-uftc8inx 5805 20 , , , cord-010092-uftc8inx 5805 21 and and CC cord-010092-uftc8inx 5805 22 if if IN cord-010092-uftc8inx 5805 23 their -PRON- PRP$ cord-010092-uftc8inx 5805 24 expression expression NN cord-010092-uftc8inx 5805 25 level level NN cord-010092-uftc8inx 5805 26 is be VBZ cord-010092-uftc8inx 5805 27 dependent dependent JJ cord-010092-uftc8inx 5805 28 on on IN cord-010092-uftc8inx 5805 29 the the DT cord-010092-uftc8inx 5805 30 storage storage NN cord-010092-uftc8inx 5805 31 period period NN cord-010092-uftc8inx 5805 32 of of IN cord-010092-uftc8inx 5805 33 RBC RBC NNP cord-010092-uftc8inx 5805 34 units unit NNS cord-010092-uftc8inx 5805 35 . . . cord-010092-uftc8inx 5806 1 Additionally additionally RB cord-010092-uftc8inx 5806 2 , , , cord-010092-uftc8inx 5806 3 by by IN cord-010092-uftc8inx 5806 4 using use VBG cord-010092-uftc8inx 5806 5 cytometric cytometric NN cord-010092-uftc8inx 5806 6 analysis analysis NN cord-010092-uftc8inx 5806 7 and and CC cord-010092-uftc8inx 5806 8 phagocytosis phagocytosis NN cord-010092-uftc8inx 5806 9 visualization visualization NN cord-010092-uftc8inx 5806 10 in in IN cord-010092-uftc8inx 5806 11 a a DT cord-010092-uftc8inx 5806 12 confocal confocal JJ cord-010092-uftc8inx 5806 13 microscope microscope NN cord-010092-uftc8inx 5806 14 , , , cord-010092-uftc8inx 5806 15 we -PRON- PRP cord-010092-uftc8inx 5806 16 examined examine VBD cord-010092-uftc8inx 5806 17 the the DT cord-010092-uftc8inx 5806 18 interactions interaction NNS cord-010092-uftc8inx 5806 19 of of IN cord-010092-uftc8inx 5806 20 donor donor NN cord-010092-uftc8inx 5806 21 monocytes monocyte NNS cord-010092-uftc8inx 5806 22 with with IN cord-010092-uftc8inx 5806 23 erythrocyte erythrocyte NN cord-010092-uftc8inx 5806 24 microvesicles microvesicle NNS cord-010092-uftc8inx 5806 25 , , , cord-010092-uftc8inx 5806 26 depending depend VBG cord-010092-uftc8inx 5806 27 on on IN cord-010092-uftc8inx 5806 28 their -PRON- PRP$ cord-010092-uftc8inx 5806 29 time time NN cord-010092-uftc8inx 5806 30 of of IN cord-010092-uftc8inx 5806 31 storage storage NN cord-010092-uftc8inx 5806 32 . . . cord-010092-uftc8inx 5807 1 Methods method NNS cord-010092-uftc8inx 5807 2 : : : cord-010092-uftc8inx 5808 1 Erythrocyte Erythrocyte NNP cord-010092-uftc8inx 5808 2 microvesicles microvesicle NNS cord-010092-uftc8inx 5808 3 were be VBD cord-010092-uftc8inx 5808 4 isolated isolate VBN cord-010092-uftc8inx 5808 5 from from IN cord-010092-uftc8inx 5808 6 " " `` cord-010092-uftc8inx 5808 7 fresh fresh JJ cord-010092-uftc8inx 5808 8 " " '' cord-010092-uftc8inx 5808 9 ( ( -LRB- cord-010092-uftc8inx 5808 10 2 2 CD cord-010092-uftc8inx 5808 11 nd nd NNP cord-010092-uftc8inx 5808 12 day day NNP cord-010092-uftc8inx 5808 13 ) ) -RRB- cord-010092-uftc8inx 5808 14 and and CC cord-010092-uftc8inx 5808 15 " " `` cord-010092-uftc8inx 5808 16 old old JJ cord-010092-uftc8inx 5808 17 " " '' cord-010092-uftc8inx 5808 18 ( ( -LRB- cord-010092-uftc8inx 5808 19 42 42 CD cord-010092-uftc8inx 5808 20 nd nd NNP cord-010092-uftc8inx 5808 21 day day NN cord-010092-uftc8inx 5808 22 ) ) -RRB- cord-010092-uftc8inx 5808 23 stored store VBD cord-010092-uftc8inx 5808 24 RBC RBC NNP cord-010092-uftc8inx 5808 25 units unit NNS cord-010092-uftc8inx 5808 26 . . . cord-010092-uftc8inx 5809 1 Qualitative qualitative JJ cord-010092-uftc8inx 5809 2 and and CC cord-010092-uftc8inx 5809 3 quantitative quantitative JJ cord-010092-uftc8inx 5809 4 cytometric cytometric NN cord-010092-uftc8inx 5809 5 analysis analysis NN cord-010092-uftc8inx 5809 6 of of IN cord-010092-uftc8inx 5809 7 these these DT cord-010092-uftc8inx 5809 8 membrane membrane NN cord-010092-uftc8inx 5809 9 structures structure NNS cord-010092-uftc8inx 5809 10 was be VBD cord-010092-uftc8inx 5809 11 performed perform VBN cord-010092-uftc8inx 5809 12 using use VBG cord-010092-uftc8inx 5809 13 the the DT cord-010092-uftc8inx 5809 14 annexin annexin NNP cord-010092-uftc8inx 5809 15 V V NNP cord-010092-uftc8inx 5809 16 - - HYPH cord-010092-uftc8inx 5809 17 FITC FITC NNP cord-010092-uftc8inx 5809 18 , , , cord-010092-uftc8inx 5809 19 anti anti JJ cord-010092-uftc8inx 5809 20 - - NNP cord-010092-uftc8inx 5809 21 CD235a CD235a NNP cord-010092-uftc8inx 5809 22 - - HYPH cord-010092-uftc8inx 5809 23 PE PE NNP cord-010092-uftc8inx 5809 24 antibody antibody NN cord-010092-uftc8inx 5809 25 , , , cord-010092-uftc8inx 5809 26 and and CC cord-010092-uftc8inx 5809 27 calibrated calibrate VBN cord-010092-uftc8inx 5809 28 beads bead NNS cord-010092-uftc8inx 5809 29 . . . cord-010092-uftc8inx 5810 1 The the DT cord-010092-uftc8inx 5810 2 microvesicles microvesicle NNS cord-010092-uftc8inx 5810 3 were be VBD cord-010092-uftc8inx 5810 4 also also RB cord-010092-uftc8inx 5810 5 visualized visualize VBN cord-010092-uftc8inx 5810 6 under under IN cord-010092-uftc8inx 5810 7 a a DT cord-010092-uftc8inx 5810 8 confocal confocal JJ cord-010092-uftc8inx 5810 9 microscope microscope NN cord-010092-uftc8inx 5810 10 . . . cord-010092-uftc8inx 5811 1 The the DT cord-010092-uftc8inx 5811 2 expression expression NN cord-010092-uftc8inx 5811 3 of of IN cord-010092-uftc8inx 5811 4 the the DT cord-010092-uftc8inx 5811 5 molecules molecule NNS cord-010092-uftc8inx 5811 6 CD235a CD235a NNP cord-010092-uftc8inx 5811 7 , , , cord-010092-uftc8inx 5811 8 CD44 CD44 NNP cord-010092-uftc8inx 5811 9 , , , cord-010092-uftc8inx 5811 10 CD47 CD47 NNP cord-010092-uftc8inx 5811 11 , , , cord-010092-uftc8inx 5811 12 CD55 CD55 NNP cord-010092-uftc8inx 5811 13 , , , cord-010092-uftc8inx 5811 14 CD59 CD59 NNP cord-010092-uftc8inx 5811 15 , , , cord-010092-uftc8inx 5811 16 and and CC cord-010092-uftc8inx 5811 17 of of IN cord-010092-uftc8inx 5811 18 phosphatidylserine phosphatidylserine NN cord-010092-uftc8inx 5811 19 was be VBD cord-010092-uftc8inx 5811 20 analysed analyse VBN cord-010092-uftc8inx 5811 21 using use VBG cord-010092-uftc8inx 5811 22 flow flow NN cord-010092-uftc8inx 5811 23 cytometry cytometry NN cord-010092-uftc8inx 5811 24 . . . cord-010092-uftc8inx 5812 1 Measurements measurement NNS cord-010092-uftc8inx 5812 2 of of IN cord-010092-uftc8inx 5812 3 microvesicle microvesicle NNP cord-010092-uftc8inx 5812 4 phagocytosis phagocytosis NN cord-010092-uftc8inx 5812 5 by by IN cord-010092-uftc8inx 5812 6 human human JJ cord-010092-uftc8inx 5812 7 monocytes monocyte NNS cord-010092-uftc8inx 5812 8 were be VBD cord-010092-uftc8inx 5812 9 carried carry VBN cord-010092-uftc8inx 5812 10 out out RP cord-010092-uftc8inx 5812 11 using use VBG cord-010092-uftc8inx 5812 12 a a DT cord-010092-uftc8inx 5812 13 flow flow NN cord-010092-uftc8inx 5812 14 cytometer cytometer NN cord-010092-uftc8inx 5812 15 and and CC cord-010092-uftc8inx 5812 16 a a DT cord-010092-uftc8inx 5812 17 confocal confocal JJ cord-010092-uftc8inx 5812 18 microscope microscope NN cord-010092-uftc8inx 5812 19 . . . cord-010092-uftc8inx 5813 1 Results result NNS cord-010092-uftc8inx 5813 2 : : : cord-010092-uftc8inx 5814 1 The the DT cord-010092-uftc8inx 5814 2 analysis analysis NN cord-010092-uftc8inx 5814 3 of of IN cord-010092-uftc8inx 5814 4 the the DT cord-010092-uftc8inx 5814 5 microvesicles microvesicle NNS cord-010092-uftc8inx 5814 6 with with IN cord-010092-uftc8inx 5814 7 calibration calibration NN cord-010092-uftc8inx 5814 8 beads bead NNS cord-010092-uftc8inx 5814 9 allowed allow VBD cord-010092-uftc8inx 5814 10 us -PRON- PRP cord-010092-uftc8inx 5814 11 to to TO cord-010092-uftc8inx 5814 12 identify identify VB cord-010092-uftc8inx 5814 13 these these DT cord-010092-uftc8inx 5814 14 structures structure NNS cord-010092-uftc8inx 5814 15 with with IN cord-010092-uftc8inx 5814 16 a a DT cord-010092-uftc8inx 5814 17 diameter diameter NN cord-010092-uftc8inx 5814 18 of of IN cord-010092-uftc8inx 5814 19 about about RB cord-010092-uftc8inx 5814 20 0.5 0.5 CD cord-010092-uftc8inx 5814 21 lm lm XX cord-010092-uftc8inx 5814 22 in in IN cord-010092-uftc8inx 5814 23 the the DT cord-010092-uftc8inx 5814 24 " " `` cord-010092-uftc8inx 5814 25 fresh fresh JJ cord-010092-uftc8inx 5814 26 " " '' cord-010092-uftc8inx 5814 27 and and CC cord-010092-uftc8inx 5814 28 " " `` cord-010092-uftc8inx 5814 29 old old JJ cord-010092-uftc8inx 5814 30 " " '' cord-010092-uftc8inx 5814 31 blood blood NN cord-010092-uftc8inx 5814 32 samples sample NNS cord-010092-uftc8inx 5814 33 . . . cord-010092-uftc8inx 5815 1 We -PRON- PRP cord-010092-uftc8inx 5815 2 observed observe VBD cord-010092-uftc8inx 5815 3 a a DT cord-010092-uftc8inx 5815 4 statistically statistically RB cord-010092-uftc8inx 5815 5 significant significant JJ cord-010092-uftc8inx 5815 6 increase increase NN cord-010092-uftc8inx 5815 7 in in IN cord-010092-uftc8inx 5815 8 the the DT cord-010092-uftc8inx 5815 9 number number NN cord-010092-uftc8inx 5815 10 of of IN cord-010092-uftc8inx 5815 11 microvesicles microvesicle NNS cord-010092-uftc8inx 5815 12 in in IN cord-010092-uftc8inx 5815 13 the the DT cord-010092-uftc8inx 5815 14 " " `` cord-010092-uftc8inx 5815 15 old old JJ cord-010092-uftc8inx 5815 16 " " '' cord-010092-uftc8inx 5815 17 units unit NNS cord-010092-uftc8inx 5815 18 ( ( -LRB- cord-010092-uftc8inx 5815 19 201 201 CD cord-010092-uftc8inx 5815 20 AE AE NNP cord-010092-uftc8inx 5815 21 139 139 CD cord-010092-uftc8inx 5815 22 MVs mv NNS cord-010092-uftc8inx 5815 23 per per IN cord-010092-uftc8inx 5815 24 1 1 CD cord-010092-uftc8inx 5815 25 ll will NN cord-010092-uftc8inx 5815 26 ) ) -RRB- cord-010092-uftc8inx 5815 27 , , , cord-010092-uftc8inx 5815 28 as as IN cord-010092-uftc8inx 5815 29 compared compare VBN cord-010092-uftc8inx 5815 30 to to IN cord-010092-uftc8inx 5815 31 the the DT cord-010092-uftc8inx 5815 32 microvesicles microvesicle NNS cord-010092-uftc8inx 5815 33 in in IN cord-010092-uftc8inx 5815 34 the the DT cord-010092-uftc8inx 5815 35 " " `` cord-010092-uftc8inx 5815 36 fresh fresh JJ cord-010092-uftc8inx 5815 37 " " '' cord-010092-uftc8inx 5815 38 ( ( -LRB- cord-010092-uftc8inx 5815 39 67 67 CD cord-010092-uftc8inx 5815 40 AE AE NNP cord-010092-uftc8inx 5815 41 53 53 CD cord-010092-uftc8inx 5815 42 MVs mv NNS cord-010092-uftc8inx 5815 43 per per IN cord-010092-uftc8inx 5815 44 1 1 CD cord-010092-uftc8inx 5815 45 ll will NN cord-010092-uftc8inx 5815 46 ) ) -RRB- cord-010092-uftc8inx 5815 47 . . . cord-010092-uftc8inx 5816 1 At at IN cord-010092-uftc8inx 5816 2 day day NN cord-010092-uftc8inx 5816 3 2 2 CD cord-010092-uftc8inx 5816 4 , , , cord-010092-uftc8inx 5816 5 the the DT cord-010092-uftc8inx 5816 6 microvesicles microvesicle NNS cord-010092-uftc8inx 5816 7 had have VBD cord-010092-uftc8inx 5816 8 elevated elevate VBN cord-010092-uftc8inx 5816 9 expression expression NN cord-010092-uftc8inx 5816 10 levels level NNS cord-010092-uftc8inx 5816 11 of of IN cord-010092-uftc8inx 5816 12 CD47 CD47 NNP cord-010092-uftc8inx 5816 13 and and CC cord-010092-uftc8inx 5816 14 reduced reduce VBN cord-010092-uftc8inx 5816 15 expression expression NN cord-010092-uftc8inx 5816 16 levels level NNS cord-010092-uftc8inx 5816 17 of of IN cord-010092-uftc8inx 5816 18 phosphatidylserine phosphatidylserine NN cord-010092-uftc8inx 5816 19 . . . cord-010092-uftc8inx 5817 1 Significant significant JJ cord-010092-uftc8inx 5817 2 changes change NNS cord-010092-uftc8inx 5817 3 were be VBD cord-010092-uftc8inx 5817 4 also also RB cord-010092-uftc8inx 5817 5 observed observe VBN cord-010092-uftc8inx 5817 6 in in IN cord-010092-uftc8inx 5817 7 the the DT cord-010092-uftc8inx 5817 8 case case NN cord-010092-uftc8inx 5817 9 of of IN cord-010092-uftc8inx 5817 10 CD55 CD55 NNP cord-010092-uftc8inx 5817 11 and and CC cord-010092-uftc8inx 5817 12 CD59 CD59 NNP cord-010092-uftc8inx 5817 13 molecules molecule NNS cord-010092-uftc8inx 5817 14 . . . cord-010092-uftc8inx 5818 1 The the DT cord-010092-uftc8inx 5818 2 expression expression NN cord-010092-uftc8inx 5818 3 of of IN cord-010092-uftc8inx 5818 4 these these DT cord-010092-uftc8inx 5818 5 molecules molecule NNS cord-010092-uftc8inx 5818 6 of of IN cord-010092-uftc8inx 5818 7 vesicles vesicle NNS cord-010092-uftc8inx 5818 8 isolated isolate VBN cord-010092-uftc8inx 5818 9 from from IN cord-010092-uftc8inx 5818 10 " " `` cord-010092-uftc8inx 5818 11 fresh fresh JJ cord-010092-uftc8inx 5818 12 " " '' cord-010092-uftc8inx 5818 13 RBCs rbc NNS cord-010092-uftc8inx 5818 14 was be VBD cord-010092-uftc8inx 5818 15 lower low JJR cord-010092-uftc8inx 5818 16 than than IN cord-010092-uftc8inx 5818 17 in in IN cord-010092-uftc8inx 5818 18 the the DT cord-010092-uftc8inx 5818 19 case case NN cord-010092-uftc8inx 5818 20 of of IN cord-010092-uftc8inx 5818 21 42-day 42-day CD cord-010092-uftc8inx 5818 22 vesicles vesicle NNS cord-010092-uftc8inx 5818 23 . . . cord-010092-uftc8inx 5819 1 The the DT cord-010092-uftc8inx 5819 2 phagocytosis phagocytosis NN cord-010092-uftc8inx 5819 3 index index NN cord-010092-uftc8inx 5819 4 was be VBD cord-010092-uftc8inx 5819 5 significantly significantly RB cord-010092-uftc8inx 5819 6 higher high JJR cord-010092-uftc8inx 5819 7 ( ( -LRB- cord-010092-uftc8inx 5819 8 28.44 28.44 CD cord-010092-uftc8inx 5819 9 % % NN cord-010092-uftc8inx 5819 10 ) ) -RRB- cord-010092-uftc8inx 5819 11 for for IN cord-010092-uftc8inx 5819 12 the the DT cord-010092-uftc8inx 5819 13 microvesicles microvesicle NNS cord-010092-uftc8inx 5819 14 isolated isolate VBN cord-010092-uftc8inx 5819 15 from from IN cord-010092-uftc8inx 5819 16 42-day 42-day CD cord-010092-uftc8inx 5819 17 stored store VBN cord-010092-uftc8inx 5819 18 RBCs rbc NNS cord-010092-uftc8inx 5819 19 than than IN cord-010092-uftc8inx 5819 20 for for IN cord-010092-uftc8inx 5819 21 microvesicles microvesicle NNS cord-010092-uftc8inx 5819 22 from from IN cord-010092-uftc8inx 5819 23 the the DT cord-010092-uftc8inx 5819 24 2- 2- CD cord-010092-uftc8inx 5819 25 Background background NN cord-010092-uftc8inx 5819 26 : : : cord-010092-uftc8inx 5819 27 Platelet platelet NN cord-010092-uftc8inx 5819 28 concentrates concentrate NNS cord-010092-uftc8inx 5819 29 ( ( -LRB- cord-010092-uftc8inx 5819 30 PCs pc NNS cord-010092-uftc8inx 5819 31 ) ) -RRB- cord-010092-uftc8inx 5819 32 are be VBP cord-010092-uftc8inx 5819 33 conventionally conventionally RB cord-010092-uftc8inx 5819 34 stored store VBN cord-010092-uftc8inx 5819 35 at at IN cord-010092-uftc8inx 5819 36 room room NN cord-010092-uftc8inx 5819 37 temperature temperature NN cord-010092-uftc8inx 5819 38 with with IN cord-010092-uftc8inx 5819 39 a a DT cord-010092-uftc8inx 5819 40 limited limited JJ cord-010092-uftc8inx 5819 41 shelf shelf NN cord-010092-uftc8inx 5819 42 - - HYPH cord-010092-uftc8inx 5819 43 life life NN cord-010092-uftc8inx 5819 44 of of IN cord-010092-uftc8inx 5819 45 5 5 CD cord-010092-uftc8inx 5819 46 - - SYM cord-010092-uftc8inx 5819 47 7 7 CD cord-010092-uftc8inx 5819 48 days day NNS cord-010092-uftc8inx 5819 49 . . . cord-010092-uftc8inx 5820 1 Alternative alternative JJ cord-010092-uftc8inx 5820 2 storage storage NN cord-010092-uftc8inx 5820 3 methods method NNS cord-010092-uftc8inx 5820 4 , , , cord-010092-uftc8inx 5820 5 such such JJ cord-010092-uftc8inx 5820 6 as as IN cord-010092-uftc8inx 5820 7 cold cold JJ cord-010092-uftc8inx 5820 8 storage storage NN cord-010092-uftc8inx 5820 9 and and CC cord-010092-uftc8inx 5820 10 cryopreservation cryopreservation NN cord-010092-uftc8inx 5820 11 are be VBP cord-010092-uftc8inx 5820 12 attractive attractive JJ cord-010092-uftc8inx 5820 13 options option NNS cord-010092-uftc8inx 5820 14 due due IN cord-010092-uftc8inx 5820 15 to to IN cord-010092-uftc8inx 5820 16 the the DT cord-010092-uftc8inx 5820 17 potential potential NN cord-010092-uftc8inx 5820 18 for for IN cord-010092-uftc8inx 5820 19 extended extended JJ cord-010092-uftc8inx 5820 20 storage storage NN cord-010092-uftc8inx 5820 21 , , , cord-010092-uftc8inx 5820 22 reduced reduce VBN cord-010092-uftc8inx 5820 23 bacterial bacterial JJ cord-010092-uftc8inx 5820 24 growth growth NN cord-010092-uftc8inx 5820 25 and and CC cord-010092-uftc8inx 5820 26 improved improved JJ cord-010092-uftc8inx 5820 27 hemostatic hemostatic JJ cord-010092-uftc8inx 5820 28 function function NN cord-010092-uftc8inx 5820 29 . . . cord-010092-uftc8inx 5821 1 Cryopreservation cryopreservation NN cord-010092-uftc8inx 5821 2 of of IN cord-010092-uftc8inx 5821 3 human human JJ cord-010092-uftc8inx 5821 4 PCs pc NNS cord-010092-uftc8inx 5821 5 has have VBZ cord-010092-uftc8inx 5821 6 been be VBN cord-010092-uftc8inx 5821 7 associated associate VBN cord-010092-uftc8inx 5821 8 with with IN cord-010092-uftc8inx 5821 9 formation formation NN cord-010092-uftc8inx 5821 10 of of IN cord-010092-uftc8inx 5821 11 more more JJR cord-010092-uftc8inx 5821 12 microparticles microparticle NNS cord-010092-uftc8inx 5821 13 and and CC cord-010092-uftc8inx 5821 14 elevated elevate VBN cord-010092-uftc8inx 5821 15 procoagulant procoagulant NN cord-010092-uftc8inx 5821 16 activity activity NN cord-010092-uftc8inx 5821 17 compared compare VBN cord-010092-uftc8inx 5821 18 to to IN cord-010092-uftc8inx 5821 19 liquid liquid NN cord-010092-uftc8inx 5821 20 - - HYPH cord-010092-uftc8inx 5821 21 stored store VBN cord-010092-uftc8inx 5821 22 ( ( -LRB- cord-010092-uftc8inx 5821 23 room room NN cord-010092-uftc8inx 5821 24 temperature temperature NN cord-010092-uftc8inx 5821 25 - - : cord-010092-uftc8inx 5821 26 and and CC cord-010092-uftc8inx 5821 27 cold cold NN cord-010092-uftc8inx 5821 28 - - HYPH cord-010092-uftc8inx 5821 29 stored store VBN cord-010092-uftc8inx 5821 30 ) ) -RRB- cord-010092-uftc8inx 5821 31 PCs pc NNS cord-010092-uftc8inx 5821 32 . . . cord-010092-uftc8inx 5822 1 Microparticles microparticle NNS cord-010092-uftc8inx 5822 2 are be VBP cord-010092-uftc8inx 5822 3 submicron submicron NN cord-010092-uftc8inx 5822 4 plasma plasma NN cord-010092-uftc8inx 5822 5 membrane membrane NN cord-010092-uftc8inx 5822 6 particles particle NNS cord-010092-uftc8inx 5822 7 that that WDT cord-010092-uftc8inx 5822 8 have have VBP cord-010092-uftc8inx 5822 9 been be VBN cord-010092-uftc8inx 5822 10 postulated postulate VBN cord-010092-uftc8inx 5822 11 as as IN cord-010092-uftc8inx 5822 12 potential potential JJ cord-010092-uftc8inx 5822 13 mediators mediator NNS cord-010092-uftc8inx 5822 14 of of IN cord-010092-uftc8inx 5822 15 adverse adverse JJ cord-010092-uftc8inx 5822 16 transfusion transfusion NN cord-010092-uftc8inx 5822 17 outcomes outcome NNS cord-010092-uftc8inx 5822 18 . . . cord-010092-uftc8inx 5823 1 Similarities similarity NNS cord-010092-uftc8inx 5823 2 in in IN cord-010092-uftc8inx 5823 3 the the DT cord-010092-uftc8inx 5823 4 size size NN cord-010092-uftc8inx 5823 5 and and CC cord-010092-uftc8inx 5823 6 storage storage NN cord-010092-uftc8inx 5823 7 - - HYPH cord-010092-uftc8inx 5823 8 related relate VBN cord-010092-uftc8inx 5823 9 changes change NNS cord-010092-uftc8inx 5823 10 up up IN cord-010092-uftc8inx 5823 11 to to TO cord-010092-uftc8inx 5823 12 7 7 CD cord-010092-uftc8inx 5823 13 days day NNS cord-010092-uftc8inx 5823 14 suggest suggest VBP cord-010092-uftc8inx 5823 15 that that IN cord-010092-uftc8inx 5823 16 sheep sheep NN cord-010092-uftc8inx 5823 17 may may MD cord-010092-uftc8inx 5823 18 be be VB cord-010092-uftc8inx 5823 19 a a DT cord-010092-uftc8inx 5823 20 suitable suitable JJ cord-010092-uftc8inx 5823 21 model model NN cord-010092-uftc8inx 5823 22 in in IN cord-010092-uftc8inx 5823 23 which which WDT cord-010092-uftc8inx 5823 24 to to TO cord-010092-uftc8inx 5823 25 investigate investigate VB cord-010092-uftc8inx 5823 26 the the DT cord-010092-uftc8inx 5823 27 effects effect NNS cord-010092-uftc8inx 5823 28 of of IN cord-010092-uftc8inx 5823 29 PC pc NN cord-010092-uftc8inx 5823 30 transfusion transfusion NN cord-010092-uftc8inx 5823 31 . . . cord-010092-uftc8inx 5824 1 Previous previous JJ cord-010092-uftc8inx 5824 2 research research NN cord-010092-uftc8inx 5824 3 has have VBZ cord-010092-uftc8inx 5824 4 established establish VBN cord-010092-uftc8inx 5824 5 that that DT cord-010092-uftc8inx 5824 6 room room NN cord-010092-uftc8inx 5824 7 temperature temperature NN cord-010092-uftc8inx 5824 8 stored store VBD cord-010092-uftc8inx 5824 9 sheep sheep NN cord-010092-uftc8inx 5824 10 PCs pc NNS cord-010092-uftc8inx 5824 11 contain contain VBP cord-010092-uftc8inx 5824 12 fewer few JJR cord-010092-uftc8inx 5824 13 microparticles microparticle NNS cord-010092-uftc8inx 5824 14 than than IN cord-010092-uftc8inx 5824 15 human human JJ cord-010092-uftc8inx 5824 16 PCs pc NNS cord-010092-uftc8inx 5824 17 . . . cord-010092-uftc8inx 5825 1 However however RB cord-010092-uftc8inx 5825 2 , , , cord-010092-uftc8inx 5825 3 nothing nothing NN cord-010092-uftc8inx 5825 4 is be VBZ cord-010092-uftc8inx 5825 5 known know VBN cord-010092-uftc8inx 5825 6 of of IN cord-010092-uftc8inx 5825 7 the the DT cord-010092-uftc8inx 5825 8 effect effect NN cord-010092-uftc8inx 5825 9 of of IN cord-010092-uftc8inx 5825 10 other other JJ cord-010092-uftc8inx 5825 11 storage storage NN cord-010092-uftc8inx 5825 12 conditions condition NNS cord-010092-uftc8inx 5825 13 . . . cord-010092-uftc8inx 5826 1 Aims aim VBZ cord-010092-uftc8inx 5826 2 : : : cord-010092-uftc8inx 5827 1 This this DT cord-010092-uftc8inx 5827 2 study study NN cord-010092-uftc8inx 5827 3 aimed aim VBD cord-010092-uftc8inx 5827 4 to to TO cord-010092-uftc8inx 5827 5 determine determine VB cord-010092-uftc8inx 5827 6 whether whether IN cord-010092-uftc8inx 5827 7 cold cold JJ cord-010092-uftc8inx 5827 8 storage storage NN cord-010092-uftc8inx 5827 9 and and CC cord-010092-uftc8inx 5827 10 cryopreservation cryopreservation NN cord-010092-uftc8inx 5827 11 contribute contribute VBP cord-010092-uftc8inx 5827 12 to to IN cord-010092-uftc8inx 5827 13 variation variation NN cord-010092-uftc8inx 5827 14 in in IN cord-010092-uftc8inx 5827 15 concentration concentration NN cord-010092-uftc8inx 5827 16 and and CC cord-010092-uftc8inx 5827 17 size size NN cord-010092-uftc8inx 5827 18 of of IN cord-010092-uftc8inx 5827 19 sheep sheep NN cord-010092-uftc8inx 5827 20 platelet platelet NN cord-010092-uftc8inx 5827 21 derived derive VBD cord-010092-uftc8inx 5827 22 microparticles microparticle NNS cord-010092-uftc8inx 5827 23 compared compare VBN cord-010092-uftc8inx 5827 24 to to IN cord-010092-uftc8inx 5827 25 conventionally conventionally RB cord-010092-uftc8inx 5827 26 stored store VBN cord-010092-uftc8inx 5827 27 sheep sheep NN cord-010092-uftc8inx 5827 28 PCs pc NNS cord-010092-uftc8inx 5827 29 . . . cord-010092-uftc8inx 5828 1 Methods method NNS cord-010092-uftc8inx 5828 2 : : : cord-010092-uftc8inx 5829 1 Sheep Sheep NNP cord-010092-uftc8inx 5829 2 buffy buffy NNP cord-010092-uftc8inx 5829 3 coat coat NN cord-010092-uftc8inx 5829 4 derived derive VBD cord-010092-uftc8inx 5829 5 PCs pc NNS cord-010092-uftc8inx 5829 6 in in IN cord-010092-uftc8inx 5829 7 30 30 CD cord-010092-uftc8inx 5829 8 % % NN cord-010092-uftc8inx 5829 9 plasma/70 plasma/70 NNP cord-010092-uftc8inx 5829 10 % % NN cord-010092-uftc8inx 5829 11 SSP+ SSP+ NNP cord-010092-uftc8inx 5829 12 were be VBD cord-010092-uftc8inx 5829 13 prepared prepare VBN cord-010092-uftc8inx 5829 14 with with IN cord-010092-uftc8inx 5829 15 minor minor JJ cord-010092-uftc8inx 5829 16 modifications modification NNS cord-010092-uftc8inx 5829 17 to to IN cord-010092-uftc8inx 5829 18 standard standard JJ cord-010092-uftc8inx 5829 19 procedures procedure NNS cord-010092-uftc8inx 5829 20 for for IN cord-010092-uftc8inx 5829 21 preparation preparation NN cord-010092-uftc8inx 5829 22 of of IN cord-010092-uftc8inx 5829 23 human human JJ cord-010092-uftc8inx 5829 24 PCs pc NNS cord-010092-uftc8inx 5829 25 . . . cord-010092-uftc8inx 5830 1 Sheep sheep NN cord-010092-uftc8inx 5830 2 PCs pc NNS cord-010092-uftc8inx 5830 3 were be VBD cord-010092-uftc8inx 5830 4 split split VBN cord-010092-uftc8inx 5830 5 into into IN cord-010092-uftc8inx 5830 6 3 3 CD cord-010092-uftc8inx 5830 7 units unit NNS cord-010092-uftc8inx 5830 8 ( ( -LRB- cord-010092-uftc8inx 5830 9 n n NN cord-010092-uftc8inx 5830 10 = = SYM cord-010092-uftc8inx 5830 11 6 6 CD cord-010092-uftc8inx 5830 12 of of IN cord-010092-uftc8inx 5830 13 each each DT cord-010092-uftc8inx 5830 14 ) ) -RRB- cord-010092-uftc8inx 5830 15 on on IN cord-010092-uftc8inx 5830 16 day day NN cord-010092-uftc8inx 5830 17 2 2 CD cord-010092-uftc8inx 5830 18 and and CC cord-010092-uftc8inx 5830 19 stored store VBN cord-010092-uftc8inx 5830 20 either either CC cord-010092-uftc8inx 5830 21 at at IN cord-010092-uftc8inx 5830 22 room room NN cord-010092-uftc8inx 5830 23 temperature temperature NN cord-010092-uftc8inx 5830 24 ( ( -LRB- cord-010092-uftc8inx 5830 25 RT RT NNP cord-010092-uftc8inx 5830 26 ; ; : cord-010092-uftc8inx 5830 27 20 20 CD cord-010092-uftc8inx 5830 28 - - SYM cord-010092-uftc8inx 5830 29 24 24 CD cord-010092-uftc8inx 5830 30 ° ° NN cord-010092-uftc8inx 5830 31 C c NN cord-010092-uftc8inx 5830 32 with with IN cord-010092-uftc8inx 5830 33 agitation agitation NN cord-010092-uftc8inx 5830 34 ) ) -RRB- cord-010092-uftc8inx 5830 35 for for IN cord-010092-uftc8inx 5830 36 5 5 CD cord-010092-uftc8inx 5830 37 days day NNS cord-010092-uftc8inx 5830 38 , , , cord-010092-uftc8inx 5830 39 cold cold JJ cord-010092-uftc8inx 5830 40 stored store VBN cord-010092-uftc8inx 5830 41 for for IN cord-010092-uftc8inx 5830 42 21 21 CD cord-010092-uftc8inx 5830 43 days day NNS cord-010092-uftc8inx 5830 44 ( ( -LRB- cord-010092-uftc8inx 5830 45 2 2 CD cord-010092-uftc8inx 5830 46 - - SYM cord-010092-uftc8inx 5830 47 6 6 CD cord-010092-uftc8inx 5830 48 ° ° NN cord-010092-uftc8inx 5830 49 C c NN cord-010092-uftc8inx 5830 50 no no DT cord-010092-uftc8inx 5830 51 agitation agitation NN cord-010092-uftc8inx 5830 52 ) ) -RRB- cord-010092-uftc8inx 5830 53 or or CC cord-010092-uftc8inx 5830 54 cryopreserved cryopreserve VBN cord-010092-uftc8inx 5830 55 ( ( -LRB- cord-010092-uftc8inx 5830 56 À80 À80 NNP cord-010092-uftc8inx 5830 57 ° ° NN cord-010092-uftc8inx 5830 58 C c NN cord-010092-uftc8inx 5830 59 with with IN cord-010092-uftc8inx 5830 60 the the DT cord-010092-uftc8inx 5830 61 addition addition NN cord-010092-uftc8inx 5830 62 of of IN cord-010092-uftc8inx 5830 63 5 5 CD cord-010092-uftc8inx 5830 64 - - SYM cord-010092-uftc8inx 5830 65 6 6 CD cord-010092-uftc8inx 5830 66 % % NN cord-010092-uftc8inx 5830 67 dimethyl dimethyl NN cord-010092-uftc8inx 5830 68 sulfoxide sulfoxide NN cord-010092-uftc8inx 5830 69 ) ) -RRB- cord-010092-uftc8inx 5830 70 for for IN cord-010092-uftc8inx 5830 71 33 33 CD cord-010092-uftc8inx 5830 72 - - SYM cord-010092-uftc8inx 5830 73 109 109 CD cord-010092-uftc8inx 5830 74 days day NNS cord-010092-uftc8inx 5830 75 and and CC cord-010092-uftc8inx 5830 76 sampled sample VBN cord-010092-uftc8inx 5830 77 post post NN cord-010092-uftc8inx 5830 78 - - NN cord-010092-uftc8inx 5830 79 thaw thaw NN cord-010092-uftc8inx 5830 80 . . . cord-010092-uftc8inx 5831 1 Platelet platelet NN cord-010092-uftc8inx 5831 2 supernatant supernatant JJ cord-010092-uftc8inx 5831 3 , , , cord-010092-uftc8inx 5831 4 prepared prepare VBN cord-010092-uftc8inx 5831 5 by by IN cord-010092-uftc8inx 5831 6 double double JJ cord-010092-uftc8inx 5831 7 centrifugation centrifugation NN cord-010092-uftc8inx 5831 8 , , , cord-010092-uftc8inx 5831 9 was be VBD cord-010092-uftc8inx 5831 10 stored store VBN cord-010092-uftc8inx 5831 11 at at IN cord-010092-uftc8inx 5831 12 À80 À80 NNP cord-010092-uftc8inx 5831 13 ° ° NN cord-010092-uftc8inx 5831 14 C C NNP cord-010092-uftc8inx 5831 15 . . . cord-010092-uftc8inx 5832 1 The the DT cord-010092-uftc8inx 5832 2 mean mean JJ cord-010092-uftc8inx 5832 3 size size NN cord-010092-uftc8inx 5832 4 and and CC cord-010092-uftc8inx 5832 5 concentration concentration NN cord-010092-uftc8inx 5832 6 of of IN cord-010092-uftc8inx 5832 7 microparticles microparticle NNS cord-010092-uftc8inx 5832 8 were be VBD cord-010092-uftc8inx 5832 9 measured measure VBN cord-010092-uftc8inx 5832 10 using use VBG cord-010092-uftc8inx 5832 11 Nanosight Nanosight NNP cord-010092-uftc8inx 5832 12 NS300 NS300 NNP cord-010092-uftc8inx 5832 13 nanoparticle nanoparticle NN cord-010092-uftc8inx 5832 14 tracking tracking NN cord-010092-uftc8inx 5832 15 analysis analysis NN cord-010092-uftc8inx 5832 16 system system NN cord-010092-uftc8inx 5832 17 ( ( -LRB- cord-010092-uftc8inx 5832 18 Malvern Malvern NNP cord-010092-uftc8inx 5832 19 Instrument Instrument NNP cord-010092-uftc8inx 5832 20 ) ) -RRB- cord-010092-uftc8inx 5832 21 . . . cord-010092-uftc8inx 5833 1 Results result NNS cord-010092-uftc8inx 5833 2 are be VBP cord-010092-uftc8inx 5833 3 mean mean JJ cord-010092-uftc8inx 5833 4 AE AE NNP cord-010092-uftc8inx 5833 5 standard standard JJ cord-010092-uftc8inx 5833 6 deviation deviation NN cord-010092-uftc8inx 5833 7 . . . cord-010092-uftc8inx 5834 1 Storage storage NN cord-010092-uftc8inx 5834 2 associated associate VBD cord-010092-uftc8inx 5834 3 changes change VBZ cord-010092-uftc8inx 5834 4 overtime overtime NN cord-010092-uftc8inx 5834 5 were be VBD cord-010092-uftc8inx 5834 6 determined determine VBN cord-010092-uftc8inx 5834 7 using use VBG cord-010092-uftc8inx 5834 8 a a DT cord-010092-uftc8inx 5834 9 one one CD cord-010092-uftc8inx 5834 10 - - HYPH cord-010092-uftc8inx 5834 11 way way NN cord-010092-uftc8inx 5834 12 analysis analysis NN cord-010092-uftc8inx 5834 13 of of IN cord-010092-uftc8inx 5834 14 variance variance NN cord-010092-uftc8inx 5834 15 with with IN cord-010092-uftc8inx 5834 16 Bonferroni Bonferroni NNP cord-010092-uftc8inx 5834 17 's 's POS cord-010092-uftc8inx 5834 18 post post JJ cord-010092-uftc8inx 5834 19 - - JJ cord-010092-uftc8inx 5834 20 test test NN cord-010092-uftc8inx 5834 21 . . . cord-010092-uftc8inx 5835 1 Paired paired JJ cord-010092-uftc8inx 5835 2 t t NN cord-010092-uftc8inx 5835 3 - - HYPH cord-010092-uftc8inx 5835 4 tests test NNS cord-010092-uftc8inx 5835 5 were be VBD cord-010092-uftc8inx 5835 6 applied apply VBN cord-010092-uftc8inx 5835 7 to to TO cord-010092-uftc8inx 5835 8 determine determine VB cord-010092-uftc8inx 5835 9 the the DT cord-010092-uftc8inx 5835 10 effect effect NN cord-010092-uftc8inx 5835 11 of of IN cord-010092-uftc8inx 5835 12 cryopreservation cryopreservation NN cord-010092-uftc8inx 5835 13 . . . cord-010092-uftc8inx 5836 1 A a DT cord-010092-uftc8inx 5836 2 P p NN cord-010092-uftc8inx 5836 3 - - HYPH cord-010092-uftc8inx 5836 4 value value NN cord-010092-uftc8inx 5836 5 of of IN cord-010092-uftc8inx 5836 6 < < NNP cord-010092-uftc8inx 5836 7 0.05 0.05 CD cord-010092-uftc8inx 5836 8 was be VBD cord-010092-uftc8inx 5836 9 considered consider VBN cord-010092-uftc8inx 5836 10 significant significant JJ cord-010092-uftc8inx 5836 11 . . . cord-010092-uftc8inx 5837 1 Results result NNS cord-010092-uftc8inx 5837 2 : : : cord-010092-uftc8inx 5838 1 At at IN cord-010092-uftc8inx 5838 2 day day NN cord-010092-uftc8inx 5838 3 2 2 CD cord-010092-uftc8inx 5838 4 , , , cord-010092-uftc8inx 5838 5 sheep sheep NN cord-010092-uftc8inx 5838 6 PCs pc NNS cord-010092-uftc8inx 5838 7 had have VBD cord-010092-uftc8inx 5838 8 a a DT cord-010092-uftc8inx 5838 9 microparticle microparticle NNP cord-010092-uftc8inx 5838 10 concentration concentration NN cord-010092-uftc8inx 5838 11 of of IN cord-010092-uftc8inx 5838 12 3.77 3.77 CD cord-010092-uftc8inx 5838 13 9 9 CD cord-010092-uftc8inx 5838 14 10 10 CD cord-010092-uftc8inx 5838 15 10 10 CD cord-010092-uftc8inx 5838 16 AE0.84 AE0.84 NNPS cord-010092-uftc8inx 5838 17 9 9 CD cord-010092-uftc8inx 5838 18 10 10 CD cord-010092-uftc8inx 5838 19 10 10 CD cord-010092-uftc8inx 5838 20 microparticles microparticle NNS cord-010092-uftc8inx 5839 1 /mL /mL NFP cord-010092-uftc8inx 5839 2 with with IN cord-010092-uftc8inx 5839 3 a a DT cord-010092-uftc8inx 5839 4 mean mean JJ cord-010092-uftc8inx 5839 5 size size NN cord-010092-uftc8inx 5839 6 of of IN cord-010092-uftc8inx 5839 7 156.6 156.6 CD cord-010092-uftc8inx 5839 8 AE16.7 ae16.7 NN cord-010092-uftc8inx 5839 9 nm nm NN cord-010092-uftc8inx 5839 10 . . . cord-010092-uftc8inx 5840 1 Storage storage NN cord-010092-uftc8inx 5840 2 duration duration NN cord-010092-uftc8inx 5840 3 at at IN cord-010092-uftc8inx 5840 4 RT RT NNP cord-010092-uftc8inx 5840 5 sheep sheep NN cord-010092-uftc8inx 5840 6 PCs pc NNS cord-010092-uftc8inx 5840 7 was be VBD cord-010092-uftc8inx 5840 8 not not RB cord-010092-uftc8inx 5840 9 associated associate VBN cord-010092-uftc8inx 5840 10 with with IN cord-010092-uftc8inx 5840 11 significant significant JJ cord-010092-uftc8inx 5840 12 changes change NNS cord-010092-uftc8inx 5840 13 to to IN cord-010092-uftc8inx 5840 14 microparticle microparticle NNP cord-010092-uftc8inx 5840 15 concentration concentration NN cord-010092-uftc8inx 5840 16 or or CC cord-010092-uftc8inx 5840 17 size size NN cord-010092-uftc8inx 5840 18 . . . cord-010092-uftc8inx 5841 1 Cryopreservation cryopreservation NN cord-010092-uftc8inx 5841 2 of of IN cord-010092-uftc8inx 5841 3 sheep sheep NN cord-010092-uftc8inx 5841 4 PCs pc NNS cord-010092-uftc8inx 5841 5 significantly significantly RB cord-010092-uftc8inx 5841 6 increased increase VBD cord-010092-uftc8inx 5841 7 the the DT cord-010092-uftc8inx 5841 8 concentration concentration NN cord-010092-uftc8inx 5841 9 ( ( -LRB- cord-010092-uftc8inx 5841 10 4.39 4.39 CD cord-010092-uftc8inx 5841 11 9 9 CD cord-010092-uftc8inx 5841 12 10 10 CD cord-010092-uftc8inx 5841 13 10 10 CD cord-010092-uftc8inx 5841 14 AE0.81 AE0.81 NNP cord-010092-uftc8inx 5841 15 9 9 CD cord-010092-uftc8inx 5841 16 10 10 CD cord-010092-uftc8inx 5841 17 10 10 CD cord-010092-uftc8inx 5841 18 microparticles/ microparticles/ CD cord-010092-uftc8inx 5841 19 mL ml NN cord-010092-uftc8inx 5841 20 ; ; : cord-010092-uftc8inx 5841 21 P p NN cord-010092-uftc8inx 5841 22 = = SYM cord-010092-uftc8inx 5841 23 0.0087 0.0087 CD cord-010092-uftc8inx 5841 24 ) ) -RRB- cord-010092-uftc8inx 5841 25 and and CC cord-010092-uftc8inx 5841 26 the the DT cord-010092-uftc8inx 5841 27 mean mean JJ cord-010092-uftc8inx 5841 28 size size NN cord-010092-uftc8inx 5841 29 ( ( -LRB- cord-010092-uftc8inx 5841 30 170.9AE 170.9ae CD cord-010092-uftc8inx 5841 31 20.5 20.5 CD cord-010092-uftc8inx 5841 32 nm nm NN cord-010092-uftc8inx 5841 33 ; ; : cord-010092-uftc8inx 5841 34 P p NN cord-010092-uftc8inx 5841 35 = = SYM cord-010092-uftc8inx 5841 36 0.0008 0.0008 CD cord-010092-uftc8inx 5841 37 ) ) -RRB- cord-010092-uftc8inx 5841 38 of of IN cord-010092-uftc8inx 5841 39 microparticles microparticle NNS cord-010092-uftc8inx 5841 40 post post NN cord-010092-uftc8inx 5841 41 - - NN cord-010092-uftc8inx 5841 42 thaw thaw NN cord-010092-uftc8inx 5841 43 . . . cord-010092-uftc8inx 5842 1 The the DT cord-010092-uftc8inx 5842 2 mean mean JJ cord-010092-uftc8inx 5842 3 size size NN cord-010092-uftc8inx 5842 4 and and CC cord-010092-uftc8inx 5842 5 concentration concentration NN cord-010092-uftc8inx 5842 6 of of IN cord-010092-uftc8inx 5842 7 microparticles microparticle NNS cord-010092-uftc8inx 5842 8 in in IN cord-010092-uftc8inx 5842 9 the the DT cord-010092-uftc8inx 5842 10 cold cold NN cord-010092-uftc8inx 5842 11 - - HYPH cord-010092-uftc8inx 5842 12 stored store VBN cord-010092-uftc8inx 5842 13 PCs pc NNS cord-010092-uftc8inx 5842 14 at at IN cord-010092-uftc8inx 5842 15 day day NN cord-010092-uftc8inx 5842 16 21 21 CD cord-010092-uftc8inx 5842 17 was be VBD cord-010092-uftc8inx 5842 18 comparable comparable JJ cord-010092-uftc8inx 5842 19 to to IN cord-010092-uftc8inx 5842 20 room room NN cord-010092-uftc8inx 5842 21 temperature temperature NN cord-010092-uftc8inx 5842 22 PCs pc NNS cord-010092-uftc8inx 5842 23 stored store VBN cord-010092-uftc8inx 5842 24 for for IN cord-010092-uftc8inx 5842 25 5 5 CD cord-010092-uftc8inx 5842 26 days day NNS cord-010092-uftc8inx 5842 27 ( ( -LRB- cord-010092-uftc8inx 5842 28 165.4 165.4 CD cord-010092-uftc8inx 5842 29 AE17.5 ae17.5 NN cord-010092-uftc8inx 5842 30 nm nm NN cord-010092-uftc8inx 5842 31 vs. vs. IN cord-010092-uftc8inx 5842 32 163.6 163.6 CD cord-010092-uftc8inx 5842 33 AE20.9 AE20.9 NNS cord-010092-uftc8inx 5842 34 nm nm NN cord-010092-uftc8inx 5842 35 ; ; : cord-010092-uftc8inx 5842 36 P p NN cord-010092-uftc8inx 5842 37 = = SYM cord-010092-uftc8inx 5842 38 0.4081 0.4081 CD cord-010092-uftc8inx 5842 39 and and CC cord-010092-uftc8inx 5842 40 4.11 4.11 CD cord-010092-uftc8inx 5842 41 9 9 CD cord-010092-uftc8inx 5842 42 10 10 CD cord-010092-uftc8inx 5842 43 10 10 CD cord-010092-uftc8inx 5843 1 AE AE NNP cord-010092-uftc8inx 5843 2 0.54 0.54 CD cord-010092-uftc8inx 5843 3 9 9 CD cord-010092-uftc8inx 5843 4 10 10 CD cord-010092-uftc8inx 5843 5 10 10 CD cord-010092-uftc8inx 5843 6 microparticles microparticle NNS cord-010092-uftc8inx 5843 7 / / SYM cord-010092-uftc8inx 5843 8 mL ml NN cord-010092-uftc8inx 5844 1 vs. vs. FW cord-010092-uftc8inx 5844 2 3.82 3.82 CD cord-010092-uftc8inx 5844 3 9 9 CD cord-010092-uftc8inx 5844 4 10 10 CD cord-010092-uftc8inx 5844 5 10 10 CD cord-010092-uftc8inx 5844 6 AE0.71 AE0.71 NNP cord-010092-uftc8inx 5844 7 9 9 CD cord-010092-uftc8inx 5844 8 10 10 CD cord-010092-uftc8inx 5844 9 10 10 CD cord-010092-uftc8inx 5844 10 microparticles microparticle NNS cord-010092-uftc8inx 5844 11 / / SYM cord-010092-uftc8inx 5844 12 mL ml NN cord-010092-uftc8inx 5844 13 ; ; : cord-010092-uftc8inx 5844 14 P p NN cord-010092-uftc8inx 5844 15 = = SYM cord-010092-uftc8inx 5844 16 0.16 0.16 CD cord-010092-uftc8inx 5844 17 respectively respectively RB cord-010092-uftc8inx 5844 18 ) ) -RRB- cord-010092-uftc8inx 5844 19 . . . cord-010092-uftc8inx 5845 1 Summary Summary NNP cord-010092-uftc8inx 5845 2 / / SYM cord-010092-uftc8inx 5845 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 5845 4 : : : cord-010092-uftc8inx 5846 1 Cold cold JJ cord-010092-uftc8inx 5846 2 storage storage NN cord-010092-uftc8inx 5846 3 of of IN cord-010092-uftc8inx 5846 4 sheep sheep NN cord-010092-uftc8inx 5846 5 PCs pc NNS cord-010092-uftc8inx 5846 6 did do VBD cord-010092-uftc8inx 5846 7 not not RB cord-010092-uftc8inx 5846 8 impact impact VB cord-010092-uftc8inx 5846 9 formation formation NN cord-010092-uftc8inx 5846 10 of of IN cord-010092-uftc8inx 5846 11 microparticles microparticle NNS cord-010092-uftc8inx 5846 12 over over IN cord-010092-uftc8inx 5846 13 the the DT cord-010092-uftc8inx 5846 14 21 21 CD cord-010092-uftc8inx 5846 15 days day NNS cord-010092-uftc8inx 5846 16 storage storage NN cord-010092-uftc8inx 5846 17 period period NN cord-010092-uftc8inx 5846 18 ; ; : cord-010092-uftc8inx 5846 19 however however RB cord-010092-uftc8inx 5846 20 , , , cord-010092-uftc8inx 5846 21 cryopreservation cryopreservation NN cord-010092-uftc8inx 5846 22 increased increase VBD cord-010092-uftc8inx 5846 23 microparticle microparticle NNP cord-010092-uftc8inx 5846 24 concentration concentration NN cord-010092-uftc8inx 5846 25 and and CC cord-010092-uftc8inx 5846 26 the the DT cord-010092-uftc8inx 5846 27 size size NN cord-010092-uftc8inx 5846 28 post post NN cord-010092-uftc8inx 5846 29 - - NN cord-010092-uftc8inx 5846 30 thaw thaw NN cord-010092-uftc8inx 5846 31 . . . cord-010092-uftc8inx 5847 1 Further further JJ cord-010092-uftc8inx 5847 2 investigation investigation NN cord-010092-uftc8inx 5847 3 is be VBZ cord-010092-uftc8inx 5847 4 required require VBN cord-010092-uftc8inx 5847 5 to to TO cord-010092-uftc8inx 5847 6 determine determine VB cord-010092-uftc8inx 5847 7 whether whether IN cord-010092-uftc8inx 5847 8 these these DT cord-010092-uftc8inx 5847 9 findings finding NNS cord-010092-uftc8inx 5847 10 are be VBP cord-010092-uftc8inx 5847 11 influence influence NN cord-010092-uftc8inx 5847 12 hemostatic hemostatic JJ cord-010092-uftc8inx 5847 13 function function NN cord-010092-uftc8inx 5847 14 . . . cord-010092-uftc8inx 5848 1 A a DT cord-010092-uftc8inx 5848 2 pre pre JJ cord-010092-uftc8inx 5848 3 - - JJ cord-010092-uftc8inx 5848 4 clinical clinical JJ cord-010092-uftc8inx 5848 5 sheep sheep NN cord-010092-uftc8inx 5848 6 model model NN cord-010092-uftc8inx 5848 7 of of IN cord-010092-uftc8inx 5848 8 cold cold NN cord-010092-uftc8inx 5848 9 - - HYPH cord-010092-uftc8inx 5848 10 stored store VBN cord-010092-uftc8inx 5848 11 and and CC cord-010092-uftc8inx 5848 12 cryopreserved cryopreserved JJ cord-010092-uftc8inx 5848 13 PC pc NN cord-010092-uftc8inx 5848 14 transfusions transfusion NNS cord-010092-uftc8inx 5848 15 can can MD cord-010092-uftc8inx 5848 16 facilitate facilitate VB cord-010092-uftc8inx 5848 17 mechanistic mechanistic JJ cord-010092-uftc8inx 5848 18 studies study NNS cord-010092-uftc8inx 5848 19 and and CC cord-010092-uftc8inx 5848 20 complement complement VB cord-010092-uftc8inx 5848 21 clinical clinical JJ cord-010092-uftc8inx 5848 22 trials trial NNS cord-010092-uftc8inx 5848 23 . . . cord-010092-uftc8inx 5849 1 Background background NN cord-010092-uftc8inx 5849 2 : : : cord-010092-uftc8inx 5850 1 During during IN cord-010092-uftc8inx 5850 2 storage storage NN cord-010092-uftc8inx 5850 3 , , , cord-010092-uftc8inx 5850 4 the the DT cord-010092-uftc8inx 5850 5 properties property NNS cord-010092-uftc8inx 5850 6 of of IN cord-010092-uftc8inx 5850 7 RBC RBC NNP cord-010092-uftc8inx 5850 8 in in IN cord-010092-uftc8inx 5850 9 storage storage NN cord-010092-uftc8inx 5850 10 solution solution NN cord-010092-uftc8inx 5850 11 change change NN cord-010092-uftc8inx 5850 12 ( ( -LRB- cord-010092-uftc8inx 5850 13 " " `` cord-010092-uftc8inx 5850 14 storage storage NN cord-010092-uftc8inx 5850 15 lesion lesion NN cord-010092-uftc8inx 5850 16 " " '' cord-010092-uftc8inx 5850 17 ) ) -RRB- cord-010092-uftc8inx 5850 18 . . . cord-010092-uftc8inx 5851 1 For for IN cord-010092-uftc8inx 5851 2 instance instance NN cord-010092-uftc8inx 5851 3 , , , cord-010092-uftc8inx 5851 4 pH pH NNP cord-010092-uftc8inx 5851 5 , , , cord-010092-uftc8inx 5851 6 ATP ATP NNP cord-010092-uftc8inx 5851 7 and and CC cord-010092-uftc8inx 5851 8 2,3-DPG 2,3-dpg CD cord-010092-uftc8inx 5851 9 concentrations concentration NNS cord-010092-uftc8inx 5851 10 decrease decrease VBP cord-010092-uftc8inx 5851 11 upon upon IN cord-010092-uftc8inx 5851 12 prolonged prolong VBN cord-010092-uftc8inx 5851 13 storage storage NN cord-010092-uftc8inx 5851 14 . . . cord-010092-uftc8inx 5852 1 These these DT cord-010092-uftc8inx 5852 2 changes change NNS cord-010092-uftc8inx 5852 3 can can MD cord-010092-uftc8inx 5852 4 affect affect VB cord-010092-uftc8inx 5852 5 oxygen oxygen NN cord-010092-uftc8inx 5852 6 delivery delivery NN cord-010092-uftc8inx 5852 7 by by IN cord-010092-uftc8inx 5852 8 the the DT cord-010092-uftc8inx 5852 9 cells cell NNS cord-010092-uftc8inx 5852 10 . . . cord-010092-uftc8inx 5853 1 The the DT cord-010092-uftc8inx 5853 2 capacity capacity NN cord-010092-uftc8inx 5853 3 to to TO cord-010092-uftc8inx 5853 4 deliver deliver VB cord-010092-uftc8inx 5853 5 oxygen oxygen NN cord-010092-uftc8inx 5853 6 is be VBZ cord-010092-uftc8inx 5853 7 defined define VBN cord-010092-uftc8inx 5853 8 as as IN cord-010092-uftc8inx 5853 9 p50 p50 NN cord-010092-uftc8inx 5853 10 : : : cord-010092-uftc8inx 5853 11 the the DT cord-010092-uftc8inx 5853 12 oxygen oxygen NN cord-010092-uftc8inx 5853 13 tension tension NN cord-010092-uftc8inx 5853 14 ( ( -LRB- cord-010092-uftc8inx 5853 15 pO2 pO2 NNP cord-010092-uftc8inx 5853 16 ) ) -RRB- cord-010092-uftc8inx 5853 17 at at IN cord-010092-uftc8inx 5853 18 which which WDT cord-010092-uftc8inx 5853 19 50 50 CD cord-010092-uftc8inx 5853 20 % % NN cord-010092-uftc8inx 5853 21 of of IN cord-010092-uftc8inx 5853 22 the the DT cord-010092-uftc8inx 5853 23 hemoglobin hemoglobin NN cord-010092-uftc8inx 5853 24 is be VBZ cord-010092-uftc8inx 5853 25 saturated saturate VBN cord-010092-uftc8inx 5853 26 with with IN cord-010092-uftc8inx 5853 27 O2 o2 NN cord-010092-uftc8inx 5853 28 . . . cord-010092-uftc8inx 5854 1 An an DT cord-010092-uftc8inx 5854 2 oxygen oxygen NN cord-010092-uftc8inx 5854 3 dissociation dissociation NN cord-010092-uftc8inx 5854 4 curve curve NN cord-010092-uftc8inx 5854 5 ( ( -LRB- cord-010092-uftc8inx 5854 6 ODC ODC NNP cord-010092-uftc8inx 5854 7 ) ) -RRB- cord-010092-uftc8inx 5854 8 represents represent VBZ cord-010092-uftc8inx 5854 9 the the DT cord-010092-uftc8inx 5854 10 non non JJ cord-010092-uftc8inx 5854 11 - - JJ cord-010092-uftc8inx 5854 12 linear linear JJ cord-010092-uftc8inx 5854 13 relationship relationship NN cord-010092-uftc8inx 5854 14 between between IN cord-010092-uftc8inx 5854 15 saturated saturated JJ cord-010092-uftc8inx 5854 16 hemoglobin hemoglobin NN cord-010092-uftc8inx 5854 17 and and CC cord-010092-uftc8inx 5854 18 pO2 po2 NN cord-010092-uftc8inx 5854 19 . . . cord-010092-uftc8inx 5855 1 This this DT cord-010092-uftc8inx 5855 2 relationship relationship NN cord-010092-uftc8inx 5855 3 is be VBZ cord-010092-uftc8inx 5855 4 dependent dependent JJ cord-010092-uftc8inx 5855 5 on on IN cord-010092-uftc8inx 5855 6 temperature temperature NN cord-010092-uftc8inx 5855 7 , , , cord-010092-uftc8inx 5855 8 pH pH NNP cord-010092-uftc8inx 5855 9 , , , cord-010092-uftc8inx 5855 10 pCO2 pCO2 NNP cord-010092-uftc8inx 5855 11 and and CC cord-010092-uftc8inx 5855 12 2,3-DPG 2,3-dpg CD cord-010092-uftc8inx 5855 13 . . . cord-010092-uftc8inx 5856 1 Due due IN cord-010092-uftc8inx 5856 2 to to IN cord-010092-uftc8inx 5856 3 changes change NNS cord-010092-uftc8inx 5856 4 in in IN cord-010092-uftc8inx 5856 5 these these DT cord-010092-uftc8inx 5856 6 factors factor NNS cord-010092-uftc8inx 5856 7 , , , cord-010092-uftc8inx 5856 8 the the DT cord-010092-uftc8inx 5856 9 curve curve NN cord-010092-uftc8inx 5856 10 will will MD cord-010092-uftc8inx 5856 11 shift shift VB cord-010092-uftc8inx 5856 12 along along IN cord-010092-uftc8inx 5856 13 the the DT cord-010092-uftc8inx 5856 14 x x NN cord-010092-uftc8inx 5856 15 - - HYPH cord-010092-uftc8inx 5856 16 axis axis NN cord-010092-uftc8inx 5856 17 . . . cord-010092-uftc8inx 5857 1 In in IN cord-010092-uftc8inx 5857 2 whole whole JJ cord-010092-uftc8inx 5857 3 blood blood NN cord-010092-uftc8inx 5857 4 , , , cord-010092-uftc8inx 5857 5 p50 p50 NN cord-010092-uftc8inx 5857 6 is be VBZ cord-010092-uftc8inx 5857 7 at at IN cord-010092-uftc8inx 5857 8 a a DT cord-010092-uftc8inx 5857 9 pO2 po2 NN cord-010092-uftc8inx 5857 10 of of IN cord-010092-uftc8inx 5858 1 about about RB cord-010092-uftc8inx 5858 2 26 26 CD cord-010092-uftc8inx 5858 3 mm mm CD cord-010092-uftc8inx 5858 4 Hg Hg NNS cord-010092-uftc8inx 5858 5 . . . cord-010092-uftc8inx 5859 1 Not not RB cord-010092-uftc8inx 5859 2 much much JJ cord-010092-uftc8inx 5859 3 is be VBZ cord-010092-uftc8inx 5859 4 known know VBN cord-010092-uftc8inx 5859 5 about about IN cord-010092-uftc8inx 5859 6 p50 p50 NN cord-010092-uftc8inx 5859 7 of of IN cord-010092-uftc8inx 5859 8 RBCs rbc NNS cord-010092-uftc8inx 5859 9 in in IN cord-010092-uftc8inx 5859 10 storage storage NN cord-010092-uftc8inx 5859 11 solution solution NN cord-010092-uftc8inx 5859 12 , , , cord-010092-uftc8inx 5859 13 and and CC cord-010092-uftc8inx 5859 14 the the DT cord-010092-uftc8inx 5859 15 changes change NNS cord-010092-uftc8inx 5859 16 during during IN cord-010092-uftc8inx 5859 17 storage storage NN cord-010092-uftc8inx 5859 18 . . . cord-010092-uftc8inx 5860 1 Aims aim VBZ cord-010092-uftc8inx 5860 2 : : : cord-010092-uftc8inx 5860 3 To to TO cord-010092-uftc8inx 5860 4 determine determine VB cord-010092-uftc8inx 5860 5 the the DT cord-010092-uftc8inx 5860 6 oxygen oxygen NN cord-010092-uftc8inx 5860 7 dissociation dissociation NN cord-010092-uftc8inx 5860 8 of of IN cord-010092-uftc8inx 5860 9 RBCs rbc NNS cord-010092-uftc8inx 5860 10 stored store VBN cord-010092-uftc8inx 5860 11 in in IN cord-010092-uftc8inx 5860 12 standard standard JJ cord-010092-uftc8inx 5860 13 red red JJ cord-010092-uftc8inx 5860 14 cell cell NN cord-010092-uftc8inx 5860 15 additive additive NN cord-010092-uftc8inx 5860 16 solution solution NN cord-010092-uftc8inx 5860 17 SAGM SAGM NNP cord-010092-uftc8inx 5860 18 and and CC cord-010092-uftc8inx 5860 19 in in IN cord-010092-uftc8inx 5860 20 PAGGGM PAGGGM NNP cord-010092-uftc8inx 5860 21 ( ( -LRB- cord-010092-uftc8inx 5860 22 an an DT cord-010092-uftc8inx 5860 23 experimental experimental JJ cord-010092-uftc8inx 5860 24 red red JJ cord-010092-uftc8inx 5860 25 cell cell NN cord-010092-uftc8inx 5860 26 additive additive NN cord-010092-uftc8inx 5860 27 solution solution NN cord-010092-uftc8inx 5860 28 , , , cord-010092-uftc8inx 5860 29 Transfusion Transfusion NNP cord-010092-uftc8inx 5860 30 . . . cord-010092-uftc8inx 5861 1 2010;50:2386 2010;50:2386 CD cord-010092-uftc8inx 5861 2 - - SYM cord-010092-uftc8inx 5861 3 92 92 CD cord-010092-uftc8inx 5861 4 ) ) -RRB- cord-010092-uftc8inx 5861 5 . . . cord-010092-uftc8inx 5862 1 Methods method NNS cord-010092-uftc8inx 5862 2 : : : cord-010092-uftc8inx 5863 1 RBCs rbc NNS cord-010092-uftc8inx 5863 2 were be VBD cord-010092-uftc8inx 5863 3 prepared prepare VBN cord-010092-uftc8inx 5863 4 in in IN cord-010092-uftc8inx 5863 5 SAGM SAGM NNP cord-010092-uftc8inx 5863 6 ( ( -LRB- cord-010092-uftc8inx 5863 7 n n NN cord-010092-uftc8inx 5863 8 = = SYM cord-010092-uftc8inx 5863 9 3 3 CD cord-010092-uftc8inx 5863 10 ) ) -RRB- cord-010092-uftc8inx 5863 11 or or CC cord-010092-uftc8inx 5863 12 PAGGGM PAGGGM NNP cord-010092-uftc8inx 5863 13 ( ( -LRB- cord-010092-uftc8inx 5863 14 n n NN cord-010092-uftc8inx 5863 15 = = SYM cord-010092-uftc8inx 5863 16 3 3 CD cord-010092-uftc8inx 5863 17 ) ) -RRB- cord-010092-uftc8inx 5863 18 . . . cord-010092-uftc8inx 5864 1 PAGGGM PAGGGM NNP cord-010092-uftc8inx 5864 2 is be VBZ cord-010092-uftc8inx 5864 3 designed design VBN cord-010092-uftc8inx 5864 4 to to TO cord-010092-uftc8inx 5864 5 better well RBR cord-010092-uftc8inx 5864 6 maintain maintain VB cord-010092-uftc8inx 5864 7 both both DT cord-010092-uftc8inx 5864 8 ATP ATP NNP cord-010092-uftc8inx 5864 9 and and CC cord-010092-uftc8inx 5864 10 2,3-DPG 2,3-dpg CD cord-010092-uftc8inx 5864 11 during during IN cord-010092-uftc8inx 5864 12 storage storage NN cord-010092-uftc8inx 5864 13 . . . cord-010092-uftc8inx 5865 1 RBCs rbc NNS cord-010092-uftc8inx 5865 2 were be VBD cord-010092-uftc8inx 5865 3 stored store VBN cord-010092-uftc8inx 5865 4 at at IN cord-010092-uftc8inx 5865 5 2 2 CD cord-010092-uftc8inx 5865 6 - - SYM cord-010092-uftc8inx 5865 7 6 6 CD cord-010092-uftc8inx 5865 8 ° ° NN cord-010092-uftc8inx 5865 9 C c NN cord-010092-uftc8inx 5865 10 and and CC cord-010092-uftc8inx 5865 11 sampled sample VBN cord-010092-uftc8inx 5865 12 on on IN cord-010092-uftc8inx 5865 13 day day NN cord-010092-uftc8inx 5865 14 1 1 CD cord-010092-uftc8inx 5865 15 , , , cord-010092-uftc8inx 5865 16 35 35 CD cord-010092-uftc8inx 5865 17 and and CC cord-010092-uftc8inx 5865 18 56 56 CD cord-010092-uftc8inx 5865 19 for for IN cord-010092-uftc8inx 5865 20 ( ( -LRB- cord-010092-uftc8inx 5865 21 internal internal JJ cord-010092-uftc8inx 5865 22 ) ) -RRB- cord-010092-uftc8inx 5865 23 pH pH NNP cord-010092-uftc8inx 5865 24 , , , cord-010092-uftc8inx 5865 25 ATP ATP NNP cord-010092-uftc8inx 5865 26 , , , cord-010092-uftc8inx 5865 27 2,3-DPG 2,3-dpg CD cord-010092-uftc8inx 5865 28 and and CC cord-010092-uftc8inx 5865 29 p50 p50 NN cord-010092-uftc8inx 5865 30 . . . cord-010092-uftc8inx 5866 1 p50 p50 NNP cord-010092-uftc8inx 5866 2 was be VBD cord-010092-uftc8inx 5866 3 determined determine VBN cord-010092-uftc8inx 5866 4 by by IN cord-010092-uftc8inx 5866 5 Hemox Hemox NNP cord-010092-uftc8inx 5866 6 analyzer analyzer NN cord-010092-uftc8inx 5866 7 ( ( -LRB- cord-010092-uftc8inx 5866 8 TCS TCS NNP cord-010092-uftc8inx 5866 9 Scientific Scientific NNP cord-010092-uftc8inx 5866 10 Corp. Corp. NNP cord-010092-uftc8inx 5866 11 ) ) -RRB- cord-010092-uftc8inx 5866 12 . . . cord-010092-uftc8inx 5867 1 The the DT cord-010092-uftc8inx 5867 2 principle principle NN cord-010092-uftc8inx 5867 3 of of IN cord-010092-uftc8inx 5867 4 the the DT cord-010092-uftc8inx 5867 5 Hemox Hemox NNP cord-010092-uftc8inx 5867 6 is be VBZ cord-010092-uftc8inx 5867 7 based base VBN cord-010092-uftc8inx 5867 8 on on IN cord-010092-uftc8inx 5867 9 the the DT cord-010092-uftc8inx 5867 10 measurement measurement NN cord-010092-uftc8inx 5867 11 of of IN cord-010092-uftc8inx 5867 12 spectrophotometric spectrophotometric JJ cord-010092-uftc8inx 5867 13 properties property NNS cord-010092-uftc8inx 5867 14 of of IN cord-010092-uftc8inx 5867 15 hemoglobin hemoglobin NN cord-010092-uftc8inx 5867 16 at at IN cord-010092-uftc8inx 5867 17 different different JJ cord-010092-uftc8inx 5867 18 oxygen oxygen NN cord-010092-uftc8inx 5867 19 pressure pressure NN cord-010092-uftc8inx 5867 20 . . . cord-010092-uftc8inx 5868 1 RBC RBC NNP cord-010092-uftc8inx 5868 2 samples sample NNS cord-010092-uftc8inx 5868 3 were be VBD cord-010092-uftc8inx 5868 4 brought bring VBN cord-010092-uftc8inx 5868 5 from from IN cord-010092-uftc8inx 5868 6 oxygen oxygen NN cord-010092-uftc8inx 5868 7 - - HYPH cord-010092-uftc8inx 5868 8 rich rich JJ cord-010092-uftc8inx 5868 9 environment environment NN cord-010092-uftc8inx 5868 10 to to IN cord-010092-uftc8inx 5868 11 oxygen oxygen NN cord-010092-uftc8inx 5868 12 - - HYPH cord-010092-uftc8inx 5868 13 poor poor JJ cord-010092-uftc8inx 5868 14 environment environment NN cord-010092-uftc8inx 5868 15 ( ( -LRB- cord-010092-uftc8inx 5868 16 2 2 CD cord-010092-uftc8inx 5868 17 % % NN cord-010092-uftc8inx 5868 18 ) ) -RRB- cord-010092-uftc8inx 5868 19 using use VBG cord-010092-uftc8inx 5868 20 N2 N2 NNP cord-010092-uftc8inx 5868 21 gas gas NN cord-010092-uftc8inx 5868 22 . . . cord-010092-uftc8inx 5869 1 p50 p50 NNP cord-010092-uftc8inx 5869 2 was be VBD cord-010092-uftc8inx 5869 3 determined determine VBN cord-010092-uftc8inx 5869 4 from from IN cord-010092-uftc8inx 5869 5 the the DT cord-010092-uftc8inx 5869 6 obtained obtain VBN cord-010092-uftc8inx 5869 7 ODC ODC NNP cord-010092-uftc8inx 5869 8 . . . cord-010092-uftc8inx 5870 1 Results result NNS cord-010092-uftc8inx 5870 2 : : : cord-010092-uftc8inx 5871 1 The the DT cord-010092-uftc8inx 5871 2 whole whole JJ cord-010092-uftc8inx 5871 3 storage storage NN cord-010092-uftc8inx 5871 4 period period NN cord-010092-uftc8inx 5871 5 , , , cord-010092-uftc8inx 5871 6 pH pH NNP cord-010092-uftc8inx 5872 1 i i PRP cord-010092-uftc8inx 5872 2 of of IN cord-010092-uftc8inx 5872 3 PAGGGM PAGGGM NNP cord-010092-uftc8inx 5872 4 - - HYPH cord-010092-uftc8inx 5872 5 RBCs rbc NNS cord-010092-uftc8inx 5872 6 was be VBD cord-010092-uftc8inx 5872 7 higher high JJR cord-010092-uftc8inx 5872 8 compared compare VBN cord-010092-uftc8inx 5872 9 to to IN cord-010092-uftc8inx 5872 10 SAGM SAGM NNP cord-010092-uftc8inx 5872 11 - - HYPH cord-010092-uftc8inx 5872 12 RBCs rbc NNS cord-010092-uftc8inx 5872 13 . . . cord-010092-uftc8inx 5873 1 2,3-DPG 2,3-dpg CD cord-010092-uftc8inx 5873 2 content content NN cord-010092-uftc8inx 5873 3 of of IN cord-010092-uftc8inx 5873 4 SAGM SAGM NNP cord-010092-uftc8inx 5873 5 - - HYPH cord-010092-uftc8inx 5873 6 RBCs rbc NNS cord-010092-uftc8inx 5873 7 decreased decrease VBD cord-010092-uftc8inx 5873 8 during during IN cord-010092-uftc8inx 5873 9 storage storage NN cord-010092-uftc8inx 5873 10 and and CC cord-010092-uftc8inx 5873 11 was be VBD cord-010092-uftc8inx 5873 12 below below IN cord-010092-uftc8inx 5873 13 the the DT cord-010092-uftc8inx 5873 14 detection detection NN cord-010092-uftc8inx 5873 15 limit limit NN cord-010092-uftc8inx 5873 16 after after IN cord-010092-uftc8inx 5873 17 day day NN cord-010092-uftc8inx 5873 18 14 14 CD cord-010092-uftc8inx 5873 19 . . . cord-010092-uftc8inx 5874 1 2,3-DPG 2,3-dpg CD cord-010092-uftc8inx 5874 2 content content NN cord-010092-uftc8inx 5874 3 of of IN cord-010092-uftc8inx 5874 4 the the DT cord-010092-uftc8inx 5874 5 PAGGGM PAGGGM NNP cord-010092-uftc8inx 5874 6 - - HYPH cord-010092-uftc8inx 5874 7 RBCs rbc NNS cord-010092-uftc8inx 5874 8 increased increase VBD cord-010092-uftc8inx 5874 9 the the DT cord-010092-uftc8inx 5874 10 first first JJ cord-010092-uftc8inx 5874 11 days day NNS cord-010092-uftc8inx 5874 12 of of IN cord-010092-uftc8inx 5874 13 storage storage NN cord-010092-uftc8inx 5874 14 and and CC cord-010092-uftc8inx 5874 15 slowly slowly RB cord-010092-uftc8inx 5874 16 decreased decrease VBD cord-010092-uftc8inx 5874 17 from from IN cord-010092-uftc8inx 5874 18 Day Day NNP cord-010092-uftc8inx 5874 19 7 7 CD cord-010092-uftc8inx 5874 20 on on RB cord-010092-uftc8inx 5874 21 . . . cord-010092-uftc8inx 5875 1 At at IN cord-010092-uftc8inx 5875 2 day day NN cord-010092-uftc8inx 5875 3 56 56 CD cord-010092-uftc8inx 5875 4 , , , cord-010092-uftc8inx 5875 5 PAGGGM PAGGGM NNP cord-010092-uftc8inx 5875 6 - - HYPH cord-010092-uftc8inx 5875 7 RBCs rbc NNS cord-010092-uftc8inx 5875 8 still still RB cord-010092-uftc8inx 5875 9 contained contain VBD cord-010092-uftc8inx 5875 10 2.3-DPG 2.3-dpg JJ cord-010092-uftc8inx 5875 11 ( ( -LRB- cord-010092-uftc8inx 5875 12 2.2 2.2 CD cord-010092-uftc8inx 5875 13 lmol lmol JJ cord-010092-uftc8inx 5875 14 / / , cord-010092-uftc8inx 5875 15 g g NNP cord-010092-uftc8inx 5875 16 Hb Hb NNP cord-010092-uftc8inx 5875 17 ) ) -RRB- cord-010092-uftc8inx 5875 18 . . . cord-010092-uftc8inx 5876 1 p50 p50 NN cord-010092-uftc8inx 5876 2 values value NNS cord-010092-uftc8inx 5876 3 decreased decrease VBD cord-010092-uftc8inx 5876 4 during during IN cord-010092-uftc8inx 5876 5 storage storage NN cord-010092-uftc8inx 5876 6 from from IN cord-010092-uftc8inx 5876 7 26 26 CD cord-010092-uftc8inx 5876 8 mmHg mmHg NNS cord-010092-uftc8inx 5876 9 at at IN cord-010092-uftc8inx 5876 10 day day NN cord-010092-uftc8inx 5876 11 1 1 CD cord-010092-uftc8inx 5876 12 to to TO cord-010092-uftc8inx 5876 13 20 20 CD cord-010092-uftc8inx 5876 14 mmHg mmHg NNS cord-010092-uftc8inx 5876 15 at at IN cord-010092-uftc8inx 5876 16 day day NN cord-010092-uftc8inx 5876 17 56 56 CD cord-010092-uftc8inx 5876 18 for for IN cord-010092-uftc8inx 5876 19 SAGM SAGM NNP cord-010092-uftc8inx 5876 20 - - HYPH cord-010092-uftc8inx 5876 21 RBC RBC NNP cord-010092-uftc8inx 5876 22 and and CC cord-010092-uftc8inx 5876 23 from from IN cord-010092-uftc8inx 5876 24 31 31 CD cord-010092-uftc8inx 5876 25 mmHg mmHg NNS cord-010092-uftc8inx 5876 26 to to IN cord-010092-uftc8inx 5876 27 26 26 CD cord-010092-uftc8inx 5876 28 mmHg mmHg NNS cord-010092-uftc8inx 5876 29 for for IN cord-010092-uftc8inx 5876 30 PAGGGM PAGGGM NNP cord-010092-uftc8inx 5876 31 - - HYPH cord-010092-uftc8inx 5876 32 RBC RBC NNP cord-010092-uftc8inx 5876 33 . . . cord-010092-uftc8inx 5877 1 p50 p50 NN cord-010092-uftc8inx 5877 2 values value NNS cord-010092-uftc8inx 5877 3 of of IN cord-010092-uftc8inx 5877 4 PAGGGM PAGGGM NNP cord-010092-uftc8inx 5877 5 - - HYPH cord-010092-uftc8inx 5877 6 RBCs rbc NNS cord-010092-uftc8inx 5877 7 were be VBD cord-010092-uftc8inx 5877 8 higher high JJR cord-010092-uftc8inx 5877 9 during during IN cord-010092-uftc8inx 5877 10 the the DT cord-010092-uftc8inx 5877 11 entire entire JJ cord-010092-uftc8inx 5877 12 storage storage NN cord-010092-uftc8inx 5877 13 period period NN cord-010092-uftc8inx 5877 14 . . . cord-010092-uftc8inx 5878 1 Summary Summary NNP cord-010092-uftc8inx 5878 2 / / SYM cord-010092-uftc8inx 5878 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 5878 4 : : : cord-010092-uftc8inx 5879 1 During during IN cord-010092-uftc8inx 5879 2 storage storage NN cord-010092-uftc8inx 5879 3 , , , cord-010092-uftc8inx 5879 4 the the DT cord-010092-uftc8inx 5879 5 p50 p50 NN cord-010092-uftc8inx 5879 6 decreased decrease VBD cord-010092-uftc8inx 5879 7 in in IN cord-010092-uftc8inx 5879 8 all all DT cord-010092-uftc8inx 5879 9 RBCs rbc NNS cord-010092-uftc8inx 5879 10 . . . cord-010092-uftc8inx 5880 1 The the DT cord-010092-uftc8inx 5880 2 p50 p50 NN cord-010092-uftc8inx 5880 3 was be VBD cord-010092-uftc8inx 5880 4 higher high JJR cord-010092-uftc8inx 5880 5 for for IN cord-010092-uftc8inx 5880 6 the the DT cord-010092-uftc8inx 5880 7 PAGGGM PAGGGM NNP cord-010092-uftc8inx 5880 8 - - HYPH cord-010092-uftc8inx 5880 9 RBCs rbc NNS cord-010092-uftc8inx 5880 10 during during IN cord-010092-uftc8inx 5880 11 the the DT cord-010092-uftc8inx 5880 12 whole whole JJ cord-010092-uftc8inx 5880 13 storage storage NN cord-010092-uftc8inx 5880 14 period period NN cord-010092-uftc8inx 5880 15 . . . cord-010092-uftc8inx 5881 1 The the DT cord-010092-uftc8inx 5881 2 higher high JJR cord-010092-uftc8inx 5881 3 p50 p50 NN cord-010092-uftc8inx 5881 4 in in IN cord-010092-uftc8inx 5881 5 PAGGGM PAGGGM NNP cord-010092-uftc8inx 5881 6 - - HYPH cord-010092-uftc8inx 5881 7 RBCS RBCS NNP cord-010092-uftc8inx 5881 8 seems seem VBZ cord-010092-uftc8inx 5881 9 to to TO cord-010092-uftc8inx 5881 10 correlate correlate VB cord-010092-uftc8inx 5881 11 with with IN cord-010092-uftc8inx 5881 12 the the DT cord-010092-uftc8inx 5881 13 higher high JJR cord-010092-uftc8inx 5881 14 2,3-DPG 2,3-dpg CD cord-010092-uftc8inx 5881 15 content content NN cord-010092-uftc8inx 5881 16 in in IN cord-010092-uftc8inx 5881 17 these these DT cord-010092-uftc8inx 5881 18 cells cell NNS cord-010092-uftc8inx 5881 19 . . . cord-010092-uftc8inx 5882 1 Background background NN cord-010092-uftc8inx 5882 2 : : : cord-010092-uftc8inx 5883 1 In in IN cord-010092-uftc8inx 5883 2 Belgium Belgium NNP cord-010092-uftc8inx 5883 3 100 100 CD cord-010092-uftc8inx 5883 4 % % NN cord-010092-uftc8inx 5883 5 of of IN cord-010092-uftc8inx 5883 6 the the DT cord-010092-uftc8inx 5883 7 platelets platelet NNS cord-010092-uftc8inx 5883 8 are be VBP cord-010092-uftc8inx 5883 9 pathogen pathogen NN cord-010092-uftc8inx 5883 10 inactivated inactivate VBN cord-010092-uftc8inx 5883 11 ( ( -LRB- cord-010092-uftc8inx 5883 12 PI PI NNP cord-010092-uftc8inx 5883 13 ) ) -RRB- cord-010092-uftc8inx 5883 14 and and CC cord-010092-uftc8inx 5883 15 legislation legislation NN cord-010092-uftc8inx 5883 16 requires require VBZ cord-010092-uftc8inx 5883 17 a a DT cord-010092-uftc8inx 5883 18 minimum minimum JJ cord-010092-uftc8inx 5883 19 platelet platelet NN cord-010092-uftc8inx 5883 20 content content NN cord-010092-uftc8inx 5883 21 of of IN cord-010092-uftc8inx 5883 22 3.0 3.0 CD cord-010092-uftc8inx 5883 23 9 9 CD cord-010092-uftc8inx 5883 24 10 10 CD cord-010092-uftc8inx 5883 25 11 11 CD cord-010092-uftc8inx 5883 26 per per IN cord-010092-uftc8inx 5883 27 Platelet platelet NN cord-010092-uftc8inx 5883 28 Concentrates concentrate NNS cord-010092-uftc8inx 5883 29 ( ( -LRB- cord-010092-uftc8inx 5883 30 PC pc NN cord-010092-uftc8inx 5883 31 ) ) -RRB- cord-010092-uftc8inx 5883 32 . . . cord-010092-uftc8inx 5884 1 Therefore therefore RB cord-010092-uftc8inx 5884 2 routine routine JJ cord-010092-uftc8inx 5884 3 pools pool NNS cord-010092-uftc8inx 5884 4 are be VBP cord-010092-uftc8inx 5884 5 produced produce VBN cord-010092-uftc8inx 5884 6 with with IN cord-010092-uftc8inx 5884 7 6 6 CD cord-010092-uftc8inx 5884 8 buffy buffy NNP cord-010092-uftc8inx 5884 9 - - HYPH cord-010092-uftc8inx 5884 10 coats coat NNS cord-010092-uftc8inx 5884 11 ( ( -LRB- cord-010092-uftc8inx 5884 12 BC BC NNP cord-010092-uftc8inx 5884 13 ) ) -RRB- cord-010092-uftc8inx 5884 14 . . . cord-010092-uftc8inx 5885 1 Facing face VBG cord-010092-uftc8inx 5885 2 increased increase VBN cord-010092-uftc8inx 5885 3 demand demand NN cord-010092-uftc8inx 5885 4 of of IN cord-010092-uftc8inx 5885 5 PC pc NN cord-010092-uftc8inx 5885 6 and and CC cord-010092-uftc8inx 5885 7 stable stable JJ cord-010092-uftc8inx 5885 8 to to IN cord-010092-uftc8inx 5885 9 slightly slightly RB cord-010092-uftc8inx 5885 10 declining decline VBG cord-010092-uftc8inx 5885 11 Red Red NNP cord-010092-uftc8inx 5885 12 Blood Blood NNP cord-010092-uftc8inx 5885 13 Cells Cells NNPS cord-010092-uftc8inx 5885 14 ( ( -LRB- cord-010092-uftc8inx 5885 15 RBC RBC NNP cord-010092-uftc8inx 5885 16 ) ) -RRB- cord-010092-uftc8inx 5885 17 demand demand NN cord-010092-uftc8inx 5885 18 , , , cord-010092-uftc8inx 5885 19 production production NN cord-010092-uftc8inx 5885 20 of of IN cord-010092-uftc8inx 5885 21 whole whole JJ cord-010092-uftc8inx 5885 22 blood blood NN cord-010092-uftc8inx 5885 23 ( ( -LRB- cord-010092-uftc8inx 5885 24 WB WB NNP cord-010092-uftc8inx 5885 25 ) ) -RRB- cord-010092-uftc8inx 5886 1 derived derived JJ cord-010092-uftc8inx 5886 2 platelets platelet NNS cord-010092-uftc8inx 5886 3 must must MD cord-010092-uftc8inx 5886 4 be be VB cord-010092-uftc8inx 5886 5 adapted adapt VBN cord-010092-uftc8inx 5886 6 to to TO cord-010092-uftc8inx 5886 7 switch switch VB cord-010092-uftc8inx 5886 8 flexibly flexibly RB cord-010092-uftc8inx 5886 9 from from IN cord-010092-uftc8inx 5886 10 6 6 CD cord-010092-uftc8inx 5886 11 to to IN cord-010092-uftc8inx 5886 12 5 5 CD cord-010092-uftc8inx 5886 13 BC BC NNP cord-010092-uftc8inx 5886 14 per per IN cord-010092-uftc8inx 5886 15 pool pool NN cord-010092-uftc8inx 5886 16 . . . cord-010092-uftc8inx 5887 1 This this DT cord-010092-uftc8inx 5887 2 dual dual JJ cord-010092-uftc8inx 5887 3 pooling pooling NN cord-010092-uftc8inx 5887 4 strategy strategy NN cord-010092-uftc8inx 5887 5 should should MD cord-010092-uftc8inx 5887 6 allow allow VB cord-010092-uftc8inx 5887 7 alignment alignment NN cord-010092-uftc8inx 5887 8 between between IN cord-010092-uftc8inx 5887 9 WB WB NNP cord-010092-uftc8inx 5887 10 collection collection NN cord-010092-uftc8inx 5887 11 forecast forecast NN cord-010092-uftc8inx 5887 12 , , , cord-010092-uftc8inx 5887 13 PC pc NN cord-010092-uftc8inx 5887 14 inventory inventory NN cord-010092-uftc8inx 5887 15 , , , cord-010092-uftc8inx 5887 16 PC pc NN cord-010092-uftc8inx 5887 17 demand demand NN cord-010092-uftc8inx 5887 18 and and CC cord-010092-uftc8inx 5887 19 PC pc NN cord-010092-uftc8inx 5887 20 production production NN cord-010092-uftc8inx 5887 21 . . . cord-010092-uftc8inx 5888 1 Aims aim VBZ cord-010092-uftc8inx 5888 2 : : : cord-010092-uftc8inx 5889 1 First first RB cord-010092-uftc8inx 5889 2 develop develop VB cord-010092-uftc8inx 5889 3 a a DT cord-010092-uftc8inx 5889 4 pooling pooling NN cord-010092-uftc8inx 5889 5 procedure procedure NN cord-010092-uftc8inx 5889 6 with with IN cord-010092-uftc8inx 5889 7 5 5 CD cord-010092-uftc8inx 5889 8 BC BC NNP cord-010092-uftc8inx 5889 9 and and CC cord-010092-uftc8inx 5889 10 250 250 CD cord-010092-uftc8inx 5889 11 ml ml NNS cord-010092-uftc8inx 5889 12 Platelets platelets NN cord-010092-uftc8inx 5889 13 Additive Additive NNP cord-010092-uftc8inx 5889 14 Solution Solution NNP cord-010092-uftc8inx 5889 15 ( ( -LRB- cord-010092-uftc8inx 5889 16 PAS pas NN cord-010092-uftc8inx 5889 17 ) ) -RRB- cord-010092-uftc8inx 5889 18 instead instead RB cord-010092-uftc8inx 5889 19 of of IN cord-010092-uftc8inx 5889 20 280 280 CD cord-010092-uftc8inx 5889 21 ml ml NNS cord-010092-uftc8inx 5889 22 for for IN cord-010092-uftc8inx 5889 23 6 6 CD cord-010092-uftc8inx 5889 24 BC BC NNP cord-010092-uftc8inx 5889 25 , , , cord-010092-uftc8inx 5889 26 without without IN cord-010092-uftc8inx 5889 27 changing change VBG cord-010092-uftc8inx 5889 28 the the DT cord-010092-uftc8inx 5889 29 settings setting NNS cord-010092-uftc8inx 5889 30 of of IN cord-010092-uftc8inx 5889 31 our -PRON- PRP$ cord-010092-uftc8inx 5889 32 WB WB NNP cord-010092-uftc8inx 5889 33 separators separator NNS cord-010092-uftc8inx 5889 34 and and CC cord-010092-uftc8inx 5889 35 platelets platelet NNS cord-010092-uftc8inx 5889 36 separators separator NNS cord-010092-uftc8inx 5889 37 . . . cord-010092-uftc8inx 5890 1 Maintain maintain VB cord-010092-uftc8inx 5890 2 a a DT cord-010092-uftc8inx 5890 3 content content NN cord-010092-uftc8inx 5890 4 of of IN cord-010092-uftc8inx 5890 5 ≥ ≥ CD cord-010092-uftc8inx 5890 6 3.0 3.0 CD cord-010092-uftc8inx 5890 7 9 9 CD cord-010092-uftc8inx 5890 8 10 10 CD cord-010092-uftc8inx 5890 9 11 11 CD cord-010092-uftc8inx 5890 10 platelets platelet NNS cord-010092-uftc8inx 5890 11 with with IN cord-010092-uftc8inx 5890 12 a a DT cord-010092-uftc8inx 5890 13 ratio ratio NN cord-010092-uftc8inx 5890 14 plasma plasma NN cord-010092-uftc8inx 5890 15 / / SYM cord-010092-uftc8inx 5890 16 PAS pas NN cord-010092-uftc8inx 5890 17 between between IN cord-010092-uftc8inx 5890 18 32 32 CD cord-010092-uftc8inx 5890 19 to to TO cord-010092-uftc8inx 5890 20 47 47 CD cord-010092-uftc8inx 5890 21 % % NN cord-010092-uftc8inx 5890 22 required require VBN cord-010092-uftc8inx 5890 23 for for IN cord-010092-uftc8inx 5890 24 PI PI NNP cord-010092-uftc8inx 5890 25 . . . cord-010092-uftc8inx 5891 1 After after IN cord-010092-uftc8inx 5891 2 validation validation NN cord-010092-uftc8inx 5891 3 , , , cord-010092-uftc8inx 5891 4 deploy deploy VB cord-010092-uftc8inx 5891 5 a a DT cord-010092-uftc8inx 5891 6 dual dual JJ cord-010092-uftc8inx 5891 7 pooling pooling NN cord-010092-uftc8inx 5891 8 strategy strategy NN cord-010092-uftc8inx 5891 9 ( ( -LRB- cord-010092-uftc8inx 5891 10 5 5 CD cord-010092-uftc8inx 5891 11 or or CC cord-010092-uftc8inx 5891 12 6 6 CD cord-010092-uftc8inx 5891 13 BC BC NNP cord-010092-uftc8inx 5891 14 / / SYM cord-010092-uftc8inx 5891 15 pool pool NN cord-010092-uftc8inx 5891 16 ) ) -RRB- cord-010092-uftc8inx 5891 17 . . . cord-010092-uftc8inx 5892 1 Methods method NNS cord-010092-uftc8inx 5892 2 : : : cord-010092-uftc8inx 5893 1 WB WB NNP cord-010092-uftc8inx 5893 2 is be VBZ cord-010092-uftc8inx 5893 3 collected collect VBN cord-010092-uftc8inx 5893 4 with with IN cord-010092-uftc8inx 5893 5 Top Top NNP cord-010092-uftc8inx 5893 6 and and CC cord-010092-uftc8inx 5893 7 Bottom bottom JJ cord-010092-uftc8inx 5893 8 Kit kit NN cord-010092-uftc8inx 5893 9 ( ( -LRB- cord-010092-uftc8inx 5893 10 COMPOSELECT COMPOSELECT NNP cord-010092-uftc8inx 5893 11 ; ; : cord-010092-uftc8inx 5893 12 FRESENIUS FRESENIUS NNP cord-010092-uftc8inx 5893 13 KABI KABI NNP cord-010092-uftc8inx 5893 14 ) ) -RRB- cord-010092-uftc8inx 5893 15 and and CC cord-010092-uftc8inx 5893 16 separated separate VBD cord-010092-uftc8inx 5893 17 ( ( -LRB- cord-010092-uftc8inx 5893 18 MACOPRESS MACOPRESS NNP cord-010092-uftc8inx 5893 19 ; ; : cord-010092-uftc8inx 5893 20 MACOPHARMA MACOPHARMA NNP cord-010092-uftc8inx 5893 21 ) ) -RRB- cord-010092-uftc8inx 5893 22 to to TO cord-010092-uftc8inx 5893 23 produce produce VB cord-010092-uftc8inx 5893 24 44 44 CD cord-010092-uftc8inx 5893 25 ml ml NN cord-010092-uftc8inx 5893 26 BC BC NNP cord-010092-uftc8inx 5893 27 with with IN cord-010092-uftc8inx 5893 28 40 40 CD cord-010092-uftc8inx 5893 29 % % NN cord-010092-uftc8inx 5893 30 haematocrit haematocrit NNP cord-010092-uftc8inx 5893 31 ( ( -LRB- cord-010092-uftc8inx 5893 32 Htc Htc NNP cord-010092-uftc8inx 5893 33 ) ) -RRB- cord-010092-uftc8inx 5893 34 and and CC cord-010092-uftc8inx 5893 35 > > XX cord-010092-uftc8inx 5893 36 90 90 CD cord-010092-uftc8inx 5893 37 % % NN cord-010092-uftc8inx 5893 38 platelets platelet NNS cord-010092-uftc8inx 5893 39 recovery recovery NN cord-010092-uftc8inx 5893 40 with with IN cord-010092-uftc8inx 5893 41 average average JJ cord-010092-uftc8inx 5893 42 platelets platelet NNS cord-010092-uftc8inx 5893 43 content content NN cord-010092-uftc8inx 5893 44 of of IN cord-010092-uftc8inx 5893 45 1 1 CD cord-010092-uftc8inx 5893 46 9 9 CD cord-010092-uftc8inx 5893 47 10 10 CD cord-010092-uftc8inx 5893 48 11 11 CD cord-010092-uftc8inx 5893 49 . . . cord-010092-uftc8inx 5894 1 5 5 CD cord-010092-uftc8inx 5894 2 random random JJ cord-010092-uftc8inx 5894 3 BC BC NNP cord-010092-uftc8inx 5894 4 are be VBP cord-010092-uftc8inx 5894 5 pooled pool VBN cord-010092-uftc8inx 5894 6 with with IN cord-010092-uftc8inx 5894 7 250 250 CD cord-010092-uftc8inx 5894 8 ml ml NNS cord-010092-uftc8inx 5894 9 or or CC cord-010092-uftc8inx 5894 10 6 6 CD cord-010092-uftc8inx 5894 11 BC BC NNP cord-010092-uftc8inx 5894 12 are be VBP cord-010092-uftc8inx 5894 13 pooled pool VBN cord-010092-uftc8inx 5894 14 with with IN cord-010092-uftc8inx 5894 15 280 280 CD cord-010092-uftc8inx 5894 16 ml ml NNS cord-010092-uftc8inx 5894 17 of of IN cord-010092-uftc8inx 5894 18 PAS pas NN cord-010092-uftc8inx 5894 19 - - HYPH cord-010092-uftc8inx 5894 20 E e NN cord-010092-uftc8inx 5894 21 , , , cord-010092-uftc8inx 5894 22 platelets platelet NNS cord-010092-uftc8inx 5894 23 are be VBP cord-010092-uftc8inx 5894 24 then then RB cord-010092-uftc8inx 5894 25 extracted extract VBN cord-010092-uftc8inx 5894 26 on on IN cord-010092-uftc8inx 5894 27 TACSI TACSI NNP cord-010092-uftc8inx 5894 28 PL PL NNP cord-010092-uftc8inx 5894 29 ( ( -LRB- cord-010092-uftc8inx 5894 30 TERUMO TERUMO NNP cord-010092-uftc8inx 5894 31 BCT BCT NNP cord-010092-uftc8inx 5894 32 ) ) -RRB- cord-010092-uftc8inx 5894 33 and and CC cord-010092-uftc8inx 5894 34 PC pc NN cord-010092-uftc8inx 5894 35 are be VBP cord-010092-uftc8inx 5894 36 treated treat VBN cord-010092-uftc8inx 5894 37 for for IN cord-010092-uftc8inx 5894 38 PI pi NN cord-010092-uftc8inx 5894 39 ( ( -LRB- cord-010092-uftc8inx 5894 40 INTERCEPT intercept VB cord-010092-uftc8inx 5894 41 BLOOD blood NN cord-010092-uftc8inx 5894 42 SYSTEM system NN cord-010092-uftc8inx 5894 43 ; ; : cord-010092-uftc8inx 5894 44 CERUS CERUS NNP cord-010092-uftc8inx 5894 45 ) ) -RRB- cord-010092-uftc8inx 5894 46 . . . cord-010092-uftc8inx 5895 1 Each each DT cord-010092-uftc8inx 5895 2 PC pc NN cord-010092-uftc8inx 5895 3 is be VBZ cord-010092-uftc8inx 5895 4 sampled sample VBN cord-010092-uftc8inx 5895 5 and and CC cord-010092-uftc8inx 5895 6 platelet platelet NN cord-010092-uftc8inx 5895 7 content content NN cord-010092-uftc8inx 5895 8 is be VBZ cord-010092-uftc8inx 5895 9 determined determine VBN cord-010092-uftc8inx 5895 10 ( ( -LRB- cord-010092-uftc8inx 5895 11 ABX ABX NNP cord-010092-uftc8inx 5895 12 PENTRA PENTRA NNS cord-010092-uftc8inx 5895 13 XL XL NNP cord-010092-uftc8inx 5895 14 80 80 CD cord-010092-uftc8inx 5895 15 ; ; : cord-010092-uftc8inx 5895 16 HORIBA HORIBA NNP cord-010092-uftc8inx 5895 17 ) ) -RRB- cord-010092-uftc8inx 5895 18 . . . cord-010092-uftc8inx 5896 1 Results result NNS cord-010092-uftc8inx 5896 2 : : : cord-010092-uftc8inx 5897 1 During during IN cord-010092-uftc8inx 5897 2 the the DT cord-010092-uftc8inx 5897 3 study study NN cord-010092-uftc8inx 5897 4 45594 45594 CD cord-010092-uftc8inx 5897 5 BC BC NNP cord-010092-uftc8inx 5897 6 were be VBD cord-010092-uftc8inx 5897 7 processed process VBN cord-010092-uftc8inx 5897 8 into into IN cord-010092-uftc8inx 5897 9 8225 8225 CD cord-010092-uftc8inx 5897 10 pools pool NNS cord-010092-uftc8inx 5897 11 ( ( -LRB- cord-010092-uftc8inx 5897 12 3756 3756 CD cord-010092-uftc8inx 5897 13 ( ( -LRB- cord-010092-uftc8inx 5897 14 45.7 45.7 CD cord-010092-uftc8inx 5897 15 % % NN cord-010092-uftc8inx 5897 16 ) ) -RRB- cord-010092-uftc8inx 5897 17 with with IN cord-010092-uftc8inx 5897 18 5 5 CD cord-010092-uftc8inx 5897 19 BC BC NNP cord-010092-uftc8inx 5897 20 and and CC cord-010092-uftc8inx 5897 21 4469 4469 CD cord-010092-uftc8inx 5897 22 ( ( -LRB- cord-010092-uftc8inx 5897 23 54.3 54.3 CD cord-010092-uftc8inx 5897 24 % % NN cord-010092-uftc8inx 5897 25 ) ) -RRB- cord-010092-uftc8inx 5897 26 with with IN cord-010092-uftc8inx 5897 27 6 6 CD cord-010092-uftc8inx 5897 28 BC BC NNP cord-010092-uftc8inx 5897 29 ) ) -RRB- cord-010092-uftc8inx 5897 30 . . . cord-010092-uftc8inx 5898 1 Before before IN cord-010092-uftc8inx 5898 2 TACSI TACSI NNP cord-010092-uftc8inx 5898 3 separation separation NN cord-010092-uftc8inx 5898 4 , , , cord-010092-uftc8inx 5898 5 BC BC NNP cord-010092-uftc8inx 5898 6 mixture mixture NN cord-010092-uftc8inx 5898 7 with with IN cord-010092-uftc8inx 5898 8 PAS pas NN cord-010092-uftc8inx 5898 9 - - HYPH cord-010092-uftc8inx 5898 10 E E NNP cord-010092-uftc8inx 5898 11 had have VBD cord-010092-uftc8inx 5898 12 volumes volume NNS cord-010092-uftc8inx 5898 13 of of IN cord-010092-uftc8inx 5898 14 421 421 CD cord-010092-uftc8inx 5898 15 AE AE NNP cord-010092-uftc8inx 5898 16 9 9 CD cord-010092-uftc8inx 5898 17 ml ml NN cord-010092-uftc8inx 5898 18 ( ( -LRB- cord-010092-uftc8inx 5898 19 5 5 CD cord-010092-uftc8inx 5898 20 BC BC NNP cord-010092-uftc8inx 5898 21 ) ) -RRB- cord-010092-uftc8inx 5898 22 and and CC cord-010092-uftc8inx 5898 23 491 491 CD cord-010092-uftc8inx 5898 24 AE AE NNP cord-010092-uftc8inx 5898 25 8 8 CD cord-010092-uftc8inx 5898 26 ml ml NN cord-010092-uftc8inx 5898 27 ( ( -LRB- cord-010092-uftc8inx 5898 28 6 6 CD cord-010092-uftc8inx 5898 29 BC BC NNP cord-010092-uftc8inx 5898 30 ) ) -RRB- cord-010092-uftc8inx 5898 31 with with IN cord-010092-uftc8inx 5898 32 respectively respectively RB cord-010092-uftc8inx 5898 33 Htc Htc NNP cord-010092-uftc8inx 5898 34 of of IN cord-010092-uftc8inx 5898 35 19 19 CD cord-010092-uftc8inx 5898 36 AE AE NNP cord-010092-uftc8inx 5898 37 1 1 CD cord-010092-uftc8inx 5898 38 % % NN cord-010092-uftc8inx 5898 39 and and CC cord-010092-uftc8inx 5898 40 20 20 CD cord-010092-uftc8inx 5898 41 AE AE NNP cord-010092-uftc8inx 5898 42 2 2 CD cord-010092-uftc8inx 5898 43 % % NN cord-010092-uftc8inx 5898 44 . . . cord-010092-uftc8inx 5899 1 The the DT cord-010092-uftc8inx 5899 2 plasma/ plasma/ NNP cord-010092-uftc8inx 5899 3 PAS pas NN cord-010092-uftc8inx 5899 4 ratio ratio NN cord-010092-uftc8inx 5899 5 was be VBD cord-010092-uftc8inx 5899 6 37 37 CD cord-010092-uftc8inx 5899 7 AE AE NNP cord-010092-uftc8inx 5899 8 1 1 CD cord-010092-uftc8inx 5899 9 % % NN cord-010092-uftc8inx 5899 10 in in IN cord-010092-uftc8inx 5899 11 both both DT cord-010092-uftc8inx 5899 12 cases case NNS cord-010092-uftc8inx 5899 13 . . . cord-010092-uftc8inx 5900 1 TACSI TACSI NNP cord-010092-uftc8inx 5900 2 separation separation NN cord-010092-uftc8inx 5900 3 was be VBD cord-010092-uftc8inx 5900 4 performed perform VBN cord-010092-uftc8inx 5900 5 with with IN cord-010092-uftc8inx 5900 6 one one CD cord-010092-uftc8inx 5900 7 same same JJ cord-010092-uftc8inx 5900 8 program program NN cord-010092-uftc8inx 5900 9 for for IN cord-010092-uftc8inx 5900 10 both both DT cord-010092-uftc8inx 5900 11 types type NNS cord-010092-uftc8inx 5900 12 of of IN cord-010092-uftc8inx 5900 13 pools pool NNS cord-010092-uftc8inx 5900 14 . . . cord-010092-uftc8inx 5901 1 After after IN cord-010092-uftc8inx 5901 2 PI PI NNP cord-010092-uftc8inx 5901 3 , , , cord-010092-uftc8inx 5901 4 platelets platelet NNS cord-010092-uftc8inx 5901 5 content content NN cord-010092-uftc8inx 5901 6 of of IN cord-010092-uftc8inx 5901 7 the the DT cord-010092-uftc8inx 5901 8 pools pool NNS cord-010092-uftc8inx 5901 9 was be VBD cord-010092-uftc8inx 5901 10 3.8 3.8 CD cord-010092-uftc8inx 5901 11 9 9 CD cord-010092-uftc8inx 5901 12 10 10 CD cord-010092-uftc8inx 5901 13 11 11 CD cord-010092-uftc8inx 5901 14 AE AE NNP cord-010092-uftc8inx 5901 15 0.5 0.5 CD cord-010092-uftc8inx 5901 16 with with IN cord-010092-uftc8inx 5901 17 5 5 CD cord-010092-uftc8inx 5901 18 BC BC NNP cord-010092-uftc8inx 5901 19 and and CC cord-010092-uftc8inx 5901 20 4.7 4.7 CD cord-010092-uftc8inx 5901 21 9 9 CD cord-010092-uftc8inx 5901 22 10 10 CD cord-010092-uftc8inx 5901 23 11 11 CD cord-010092-uftc8inx 5901 24 AE AE NNP cord-010092-uftc8inx 5901 25 0.5 0.5 CD cord-010092-uftc8inx 5901 26 with with IN cord-010092-uftc8inx 5901 27 6 6 CD cord-010092-uftc8inx 5901 28 BC BC NNP cord-010092-uftc8inx 5901 29 ( ( -LRB- cord-010092-uftc8inx 5901 30 Average average JJ cord-010092-uftc8inx 5901 31 AE AE NNP cord-010092-uftc8inx 5901 32 Standard Standard NNP cord-010092-uftc8inx 5901 33 Deviation Deviation NNP cord-010092-uftc8inx 5901 34 ) ) -RRB- cord-010092-uftc8inx 5901 35 . . . cord-010092-uftc8inx 5902 1 Pools pool NNS cord-010092-uftc8inx 5902 2 below below IN cord-010092-uftc8inx 5902 3 the the DT cord-010092-uftc8inx 5902 4 limit limit NN cord-010092-uftc8inx 5902 5 of of IN cord-010092-uftc8inx 5902 6 < < NNP cord-010092-uftc8inx 5902 7 3.0 3.0 CD cord-010092-uftc8inx 5902 8 9 9 CD cord-010092-uftc8inx 5902 9 10 10 CD cord-010092-uftc8inx 5902 10 11 11 CD cord-010092-uftc8inx 5902 11 were be VBD cord-010092-uftc8inx 5902 12 139/3756 139/3756 CD cord-010092-uftc8inx 5902 13 ( ( -LRB- cord-010092-uftc8inx 5902 14 3.7 3.7 CD cord-010092-uftc8inx 5902 15 % % NN cord-010092-uftc8inx 5902 16 ) ) -RRB- cord-010092-uftc8inx 5902 17 with with IN cord-010092-uftc8inx 5902 18 5 5 CD cord-010092-uftc8inx 5902 19 BC BC NNP cord-010092-uftc8inx 5902 20 and and CC cord-010092-uftc8inx 5902 21 1/4469 1/4469 CD cord-010092-uftc8inx 5902 22 ( ( -LRB- cord-010092-uftc8inx 5902 23 0.02 0.02 CD cord-010092-uftc8inx 5902 24 % % NN cord-010092-uftc8inx 5902 25 ) ) -RRB- cord-010092-uftc8inx 5902 26 with with IN cord-010092-uftc8inx 5902 27 6 6 CD cord-010092-uftc8inx 5902 28 BC BC NNP cord-010092-uftc8inx 5902 29 . . . cord-010092-uftc8inx 5903 1 The the DT cord-010092-uftc8inx 5903 2 platelets platelet NNS cord-010092-uftc8inx 5903 3 concentrations concentration NNS cord-010092-uftc8inx 5903 4 ( ( -LRB- cord-010092-uftc8inx 5903 5 10 10 CD cord-010092-uftc8inx 5903 6 3 3 CD cord-010092-uftc8inx 5903 7 /lL /lL . cord-010092-uftc8inx 5903 8 ) ) -RRB- cord-010092-uftc8inx 5903 9 were be VBD cord-010092-uftc8inx 5903 10 1395 1395 CD cord-010092-uftc8inx 5903 11 AE AE NNP cord-010092-uftc8inx 5903 12 167 167 CD cord-010092-uftc8inx 5903 13 ( ( -LRB- cord-010092-uftc8inx 5903 14 5 5 CD cord-010092-uftc8inx 5903 15 BC BC NNP cord-010092-uftc8inx 5903 16 ) ) -RRB- cord-010092-uftc8inx 5903 17 and and CC cord-010092-uftc8inx 5903 18 1491 1491 CD cord-010092-uftc8inx 5903 19 AE AE NNP cord-010092-uftc8inx 5903 20 155 155 CD cord-010092-uftc8inx 5903 21 ( ( -LRB- cord-010092-uftc8inx 5903 22 6 6 CD cord-010092-uftc8inx 5903 23 BC BC NNP cord-010092-uftc8inx 5903 24 ) ) -RRB- cord-010092-uftc8inx 5903 25 . . . cord-010092-uftc8inx 5904 1 Platelets platelet NNS cord-010092-uftc8inx 5904 2 recovery recovery NN cord-010092-uftc8inx 5904 3 was be VBD cord-010092-uftc8inx 5904 4 85 85 CD cord-010092-uftc8inx 5904 5 % % NN cord-010092-uftc8inx 5904 6 AE5 AE5 NNP cord-010092-uftc8inx 5904 7 for for IN cord-010092-uftc8inx 5904 8 5 5 CD cord-010092-uftc8inx 5904 9 BC BC NNP cord-010092-uftc8inx 5904 10 and and CC cord-010092-uftc8inx 5904 11 86 86 CD cord-010092-uftc8inx 5904 12 % % NN cord-010092-uftc8inx 5904 13 AE AE NNP cord-010092-uftc8inx 5904 14 6 6 CD cord-010092-uftc8inx 5904 15 for for IN cord-010092-uftc8inx 5904 16 6 6 CD cord-010092-uftc8inx 5904 17 BC BC NNP cord-010092-uftc8inx 5904 18 . . . cord-010092-uftc8inx 5905 1 Summary Summary NNP cord-010092-uftc8inx 5905 2 / / SYM cord-010092-uftc8inx 5905 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 5905 4 : : : cord-010092-uftc8inx 5906 1 45594 45594 CD cord-010092-uftc8inx 5906 2 BC BC NNP cord-010092-uftc8inx 5906 3 could could MD cord-010092-uftc8inx 5906 4 theoretically theoretically RB cord-010092-uftc8inx 5906 5 produce produce VB cord-010092-uftc8inx 5906 6 7599 7599 CD cord-010092-uftc8inx 5906 7 pools pool NNS cord-010092-uftc8inx 5906 8 of of IN cord-010092-uftc8inx 5906 9 6 6 CD cord-010092-uftc8inx 5906 10 BC BC NNP cord-010092-uftc8inx 5906 11 or or CC cord-010092-uftc8inx 5906 12 9118 9118 CD cord-010092-uftc8inx 5906 13 pools pool NNS cord-010092-uftc8inx 5906 14 of of IN cord-010092-uftc8inx 5906 15 5 5 CD cord-010092-uftc8inx 5906 16 BC BC NNP cord-010092-uftc8inx 5906 17 . . . cord-010092-uftc8inx 5907 1 This this DT cord-010092-uftc8inx 5907 2 means mean VBZ cord-010092-uftc8inx 5907 3 a a DT cord-010092-uftc8inx 5907 4 maximum maximum JJ cord-010092-uftc8inx 5907 5 potential potential JJ cord-010092-uftc8inx 5907 6 gain gain NN cord-010092-uftc8inx 5907 7 of of IN cord-010092-uftc8inx 5907 8 + + SYM cord-010092-uftc8inx 5907 9 20 20 CD cord-010092-uftc8inx 5907 10 % % NN cord-010092-uftc8inx 5907 11 PC pc NN cord-010092-uftc8inx 5907 12 . . . cord-010092-uftc8inx 5908 1 In in IN cord-010092-uftc8inx 5908 2 practice practice NN cord-010092-uftc8inx 5908 3 during during IN cord-010092-uftc8inx 5908 4 shortage shortage NN cord-010092-uftc8inx 5908 5 periods period NNS cord-010092-uftc8inx 5908 6 we -PRON- PRP cord-010092-uftc8inx 5908 7 switched switch VBD cord-010092-uftc8inx 5908 8 from from IN cord-010092-uftc8inx 5908 9 6 6 CD cord-010092-uftc8inx 5908 10 to to IN cord-010092-uftc8inx 5908 11 5 5 CD cord-010092-uftc8inx 5908 12 BC BC NNP cord-010092-uftc8inx 5908 13 when when WRB cord-010092-uftc8inx 5908 14 dictated dictate VBN cord-010092-uftc8inx 5908 15 by by IN cord-010092-uftc8inx 5908 16 the the DT cord-010092-uftc8inx 5908 17 actual actual JJ cord-010092-uftc8inx 5908 18 inventory inventory NN cord-010092-uftc8inx 5908 19 levels level NNS cord-010092-uftc8inx 5908 20 and and CC cord-010092-uftc8inx 5908 21 hospital hospital NN cord-010092-uftc8inx 5908 22 needs need NNS cord-010092-uftc8inx 5908 23 . . . cord-010092-uftc8inx 5909 1 The the DT cord-010092-uftc8inx 5909 2 advantage advantage NN cord-010092-uftc8inx 5909 3 of of IN cord-010092-uftc8inx 5909 4 this this DT cord-010092-uftc8inx 5909 5 dual dual JJ cord-010092-uftc8inx 5909 6 pooling pooling NN cord-010092-uftc8inx 5909 7 strategy strategy NN cord-010092-uftc8inx 5909 8 was be VBD cord-010092-uftc8inx 5909 9 a a DT cord-010092-uftc8inx 5909 10 gain gain NN cord-010092-uftc8inx 5909 11 in in IN cord-010092-uftc8inx 5909 12 production production NN cord-010092-uftc8inx 5909 13 capacity capacity NN cord-010092-uftc8inx 5909 14 to to TO cord-010092-uftc8inx 5909 15 cover cover VB cord-010092-uftc8inx 5909 16 these these DT cord-010092-uftc8inx 5909 17 shortage shortage NN cord-010092-uftc8inx 5909 18 periods period NNS cord-010092-uftc8inx 5909 19 ( ( -LRB- cord-010092-uftc8inx 5909 20 626 626 CD cord-010092-uftc8inx 5909 21 PC pc NN cord-010092-uftc8inx 5909 22 , , , cord-010092-uftc8inx 5909 23 +8 +8 CD cord-010092-uftc8inx 5909 24 % % NN cord-010092-uftc8inx 5909 25 ) ) -RRB- cord-010092-uftc8inx 5909 26 . . . cord-010092-uftc8inx 5910 1 The the DT cord-010092-uftc8inx 5910 2 disadvantage disadvantage NN cord-010092-uftc8inx 5910 3 of of IN cord-010092-uftc8inx 5910 4 pooling pool VBG cord-010092-uftc8inx 5910 5 randomly randomly RB cord-010092-uftc8inx 5910 6 5 5 CD cord-010092-uftc8inx 5910 7 BC BC NNP cord-010092-uftc8inx 5910 8 is be VBZ cord-010092-uftc8inx 5910 9 that that IN cord-010092-uftc8inx 5910 10 139 139 CD cord-010092-uftc8inx 5910 11 pools pool NNS cord-010092-uftc8inx 5910 12 contained contain VBD cord-010092-uftc8inx 5910 13 less less JJR cord-010092-uftc8inx 5910 14 than than IN cord-010092-uftc8inx 5910 15 3.0 3.0 CD cord-010092-uftc8inx 5910 16 9 9 CD cord-010092-uftc8inx 5910 17 10 10 CD cord-010092-uftc8inx 5910 18 11 11 CD cord-010092-uftc8inx 5910 19 platelets platelet NNS cord-010092-uftc8inx 5910 20 per per IN cord-010092-uftc8inx 5910 21 pool pool NN cord-010092-uftc8inx 5910 22 potentially potentially RB cord-010092-uftc8inx 5910 23 limiting limit VBG cord-010092-uftc8inx 5910 24 their -PRON- PRP$ cord-010092-uftc8inx 5910 25 usage usage NN cord-010092-uftc8inx 5910 26 to to IN cord-010092-uftc8inx 5910 27 low low JJ cord-010092-uftc8inx 5910 28 weight weight NN cord-010092-uftc8inx 5910 29 or or CC cord-010092-uftc8inx 5910 30 paediatric paediatric JJ cord-010092-uftc8inx 5910 31 patients patient NNS cord-010092-uftc8inx 5910 32 . . . cord-010092-uftc8inx 5911 1 A a DT cord-010092-uftc8inx 5911 2 preselection preselection NN cord-010092-uftc8inx 5911 3 of of IN cord-010092-uftc8inx 5911 4 the the DT cord-010092-uftc8inx 5911 5 BC BC NNP cord-010092-uftc8inx 5911 6 based base VBN cord-010092-uftc8inx 5911 7 on on IN cord-010092-uftc8inx 5911 8 platelet platelet NN cord-010092-uftc8inx 5911 9 count count NN cord-010092-uftc8inx 5911 10 could could MD cord-010092-uftc8inx 5911 11 optimize optimize VB cord-010092-uftc8inx 5911 12 the the DT cord-010092-uftc8inx 5911 13 5 5 CD cord-010092-uftc8inx 5911 14 BC BC NNP cord-010092-uftc8inx 5911 15 pooling pooling NN cord-010092-uftc8inx 5911 16 procedure procedure NN cord-010092-uftc8inx 5911 17 . . . cord-010092-uftc8inx 5912 1 Background background NN cord-010092-uftc8inx 5912 2 : : : cord-010092-uftc8inx 5913 1 Apheresis Apheresis NNP cord-010092-uftc8inx 5913 2 - - HYPH cord-010092-uftc8inx 5913 3 derived derive VBN cord-010092-uftc8inx 5913 4 platelet platelet NN cord-010092-uftc8inx 5913 5 concentrates concentrate VBZ cord-010092-uftc8inx 5913 6 ( ( -LRB- cord-010092-uftc8inx 5913 7 APCs apc NNS cord-010092-uftc8inx 5913 8 ) ) -RRB- cord-010092-uftc8inx 5913 9 is be VBZ cord-010092-uftc8inx 5913 10 a a DT cord-010092-uftc8inx 5913 11 standard standard JJ cord-010092-uftc8inx 5913 12 medical medical JJ cord-010092-uftc8inx 5913 13 therapy therapy NN cord-010092-uftc8inx 5913 14 indispensable indispensable JJ cord-010092-uftc8inx 5913 15 to to IN cord-010092-uftc8inx 5913 16 contrast contrast NN cord-010092-uftc8inx 5913 17 bleeding bleeding NN cord-010092-uftc8inx 5913 18 or or CC cord-010092-uftc8inx 5913 19 hemorrhage hemorrhage NN cord-010092-uftc8inx 5913 20 . . . cord-010092-uftc8inx 5914 1 However however RB cord-010092-uftc8inx 5914 2 , , , cord-010092-uftc8inx 5914 3 bacterial bacterial JJ cord-010092-uftc8inx 5914 4 infection infection NN cord-010092-uftc8inx 5914 5 caused cause VBN cord-010092-uftc8inx 5914 6 by by IN cord-010092-uftc8inx 5914 7 storage storage NN cord-010092-uftc8inx 5914 8 at at IN cord-010092-uftc8inx 5914 9 room room NN cord-010092-uftc8inx 5914 10 temperature temperature NN cord-010092-uftc8inx 5914 11 ( ( -LRB- cord-010092-uftc8inx 5914 12 RT RT NNP cord-010092-uftc8inx 5914 13 ) ) -RRB- cord-010092-uftc8inx 5914 14 still still RB cord-010092-uftc8inx 5914 15 remains remain VBZ cord-010092-uftc8inx 5914 16 the the DT cord-010092-uftc8inx 5914 17 major major JJ cord-010092-uftc8inx 5914 18 drawback drawback NN cord-010092-uftc8inx 5914 19 . . . cord-010092-uftc8inx 5915 1 Recently recently RB cord-010092-uftc8inx 5915 2 , , , cord-010092-uftc8inx 5915 3 we -PRON- PRP cord-010092-uftc8inx 5915 4 showed show VBD cord-010092-uftc8inx 5915 5 that that IN cord-010092-uftc8inx 5915 6 cold cold NN cord-010092-uftc8inx 5915 7 - - HYPH cord-010092-uftc8inx 5915 8 stored store VBN cord-010092-uftc8inx 5915 9 APCs apc NNS cord-010092-uftc8inx 5915 10 are be VBP cord-010092-uftc8inx 5915 11 associated associate VBN cord-010092-uftc8inx 5915 12 with with IN cord-010092-uftc8inx 5915 13 better well JJR cord-010092-uftc8inx 5915 14 PLT PLT NNP cord-010092-uftc8inx 5915 15 functionality functionality NN cord-010092-uftc8inx 5915 16 but but CC cord-010092-uftc8inx 5915 17 with with IN cord-010092-uftc8inx 5915 18 accelerated accelerated JJ cord-010092-uftc8inx 5915 19 clearance clearance NN cord-010092-uftc8inx 5915 20 ( ( -LRB- cord-010092-uftc8inx 5915 21 Haematologica Haematologica NNP cord-010092-uftc8inx 5915 22 2018 2018 CD cord-010092-uftc8inx 5915 23 , , , cord-010092-uftc8inx 5915 24 PMID PMID NNP cord-010092-uftc8inx 5915 25 : : : cord-010092-uftc8inx 5915 26 30115655 30115655 CD cord-010092-uftc8inx 5915 27 ) ) -RRB- cord-010092-uftc8inx 5915 28 . . . cord-010092-uftc8inx 5916 1 Cold cold JJ cord-010092-uftc8inx 5916 2 - - HYPH cord-010092-uftc8inx 5916 3 induced induce VBN cord-010092-uftc8inx 5916 4 apoptosis apoptosis NN cord-010092-uftc8inx 5916 5 was be VBD cord-010092-uftc8inx 5916 6 identified identify VBN cord-010092-uftc8inx 5916 7 as as IN cord-010092-uftc8inx 5916 8 a a DT cord-010092-uftc8inx 5916 9 potential potential JJ cord-010092-uftc8inx 5916 10 mechanism mechanism NN cord-010092-uftc8inx 5916 11 of of IN cord-010092-uftc8inx 5916 12 the the DT cord-010092-uftc8inx 5916 13 shorter short JJR cord-010092-uftc8inx 5916 14 PLT PLT NNP cord-010092-uftc8inx 5916 15 survival survival NN cord-010092-uftc8inx 5916 16 Aims aim VBZ cord-010092-uftc8inx 5916 17 : : : cord-010092-uftc8inx 5916 18 To to TO cord-010092-uftc8inx 5916 19 investigate investigate VB cord-010092-uftc8inx 5916 20 the the DT cord-010092-uftc8inx 5916 21 protective protective JJ cord-010092-uftc8inx 5916 22 effect effect NN cord-010092-uftc8inx 5916 23 of of IN cord-010092-uftc8inx 5916 24 apoptotic apoptotic JJ cord-010092-uftc8inx 5916 25 inhibitors inhibitor NNS cord-010092-uftc8inx 5916 26 during during IN cord-010092-uftc8inx 5916 27 cold cold JJ cord-010092-uftc8inx 5916 28 storage storage NN cord-010092-uftc8inx 5916 29 of of IN cord-010092-uftc8inx 5916 30 APCs apc NNS cord-010092-uftc8inx 5916 31 Methods method NNS cord-010092-uftc8inx 5916 32 : : : cord-010092-uftc8inx 5916 33 APCs apc NNS cord-010092-uftc8inx 5916 34 were be VBD cord-010092-uftc8inx 5916 35 collected collect VBN cord-010092-uftc8inx 5916 36 and and CC cord-010092-uftc8inx 5916 37 stored store VBN cord-010092-uftc8inx 5916 38 at at IN cord-010092-uftc8inx 5916 39 RT RT NNP cord-010092-uftc8inx 5916 40 and and CC cord-010092-uftc8inx 5916 41 4 4 CD cord-010092-uftc8inx 5916 42 ° ° NN cord-010092-uftc8inx 5916 43 C c NN cord-010092-uftc8inx 5916 44 in in IN cord-010092-uftc8inx 5916 45 the the DT cord-010092-uftc8inx 5916 46 presence presence NN cord-010092-uftc8inx 5916 47 or or CC cord-010092-uftc8inx 5916 48 in in IN cord-010092-uftc8inx 5916 49 the the DT cord-010092-uftc8inx 5916 50 absence absence NN cord-010092-uftc8inx 5916 51 of of IN cord-010092-uftc8inx 5916 52 caspase-3 caspase-3 NNP cord-010092-uftc8inx 5916 53 inhibitor inhibitor NN cord-010092-uftc8inx 5916 54 . . . cord-010092-uftc8inx 5917 1 The the DT cord-010092-uftc8inx 5917 2 phosphatidylserine phosphatidylserine NN cord-010092-uftc8inx 5917 3 exposure exposure NN cord-010092-uftc8inx 5917 4 and and CC cord-010092-uftc8inx 5917 5 the the DT cord-010092-uftc8inx 5917 6 mitochondrial mitochondrial JJ cord-010092-uftc8inx 5917 7 membrane membrane NN cord-010092-uftc8inx 5917 8 potential potential NN cord-010092-uftc8inx 5917 9 ( ( -LRB- cord-010092-uftc8inx 5917 10 MMP MMP NNP cord-010092-uftc8inx 5917 11 ) ) -RRB- cord-010092-uftc8inx 5917 12 ( ( -LRB- cord-010092-uftc8inx 5917 13 tetramethylrhodamine tetramethylrhodamine NNP cord-010092-uftc8inx 5917 14 ethyl ethyl NNP cord-010092-uftc8inx 5917 15 ester ester NN cord-010092-uftc8inx 5917 16 perchlorate perchlorate NN cord-010092-uftc8inx 5917 17 [ [ -LRB- cord-010092-uftc8inx 5917 18 TMRE TMRE NNP cord-010092-uftc8inx 5917 19 ] ] -RRB- cord-010092-uftc8inx 5917 20 staining stain VBG cord-010092-uftc8inx 5917 21 ) ) -RRB- cord-010092-uftc8inx 5917 22 were be VBD cord-010092-uftc8inx 5917 23 measured measure VBN cord-010092-uftc8inx 5917 24 using use VBG cord-010092-uftc8inx 5917 25 flow flow NN cord-010092-uftc8inx 5917 26 cytometry cytometry NN cord-010092-uftc8inx 5917 27 . . . cord-010092-uftc8inx 5918 1 The the DT cord-010092-uftc8inx 5918 2 protein protein NN cord-010092-uftc8inx 5918 3 expression expression NN cord-010092-uftc8inx 5918 4 was be VBD cord-010092-uftc8inx 5918 5 quantified quantify VBN cord-010092-uftc8inx 5918 6 by by IN cord-010092-uftc8inx 5918 7 western western JJ cord-010092-uftc8inx 5918 8 blot blot NN cord-010092-uftc8inx 5918 9 Results result NNS cord-010092-uftc8inx 5918 10 : : : cord-010092-uftc8inx 5918 11 A a DT cord-010092-uftc8inx 5918 12 higher high JJR cord-010092-uftc8inx 5918 13 expression expression NN cord-010092-uftc8inx 5918 14 of of IN cord-010092-uftc8inx 5918 15 the the DT cord-010092-uftc8inx 5918 16 apoptotic apoptotic JJ cord-010092-uftc8inx 5918 17 marker marker NN cord-010092-uftc8inx 5918 18 phosphatidylserine phosphatidylserine NN cord-010092-uftc8inx 5918 19 was be VBD cord-010092-uftc8inx 5918 20 detected detect VBN cord-010092-uftc8inx 5918 21 in in IN cord-010092-uftc8inx 5918 22 cold cold NN cord-010092-uftc8inx 5918 23 - - HYPH cord-010092-uftc8inx 5918 24 stored store VBN cord-010092-uftc8inx 5918 25 APC APC NNP cord-010092-uftc8inx 5918 26 compared compare VBN cord-010092-uftc8inx 5918 27 to to IN cord-010092-uftc8inx 5918 28 RT RT NNP cord-010092-uftc8inx 5918 29 ( ( -LRB- cord-010092-uftc8inx 5918 30 % % NN cord-010092-uftc8inx 5918 31 apoptotic apoptotic JJ cord-010092-uftc8inx 5918 32 events event NNS cord-010092-uftc8inx 5919 1 meanAESEM meanAESEM NNP cord-010092-uftc8inx 5919 2 : : : cord-010092-uftc8inx 5920 1 13 13 CD cord-010092-uftc8inx 5920 2 AE AE NNP cord-010092-uftc8inx 5920 3 1 1 CD cord-010092-uftc8inx 5920 4 % % NN cord-010092-uftc8inx 5920 5 vs. vs. NN cord-010092-uftc8inx 5920 6 5 5 CD cord-010092-uftc8inx 5920 7 AE AE NNP cord-010092-uftc8inx 5920 8 1 1 CD cord-010092-uftc8inx 5920 9 % % NN cord-010092-uftc8inx 5920 10 P p NN cord-010092-uftc8inx 5920 11 = = SYM cord-010092-uftc8inx 5920 12 0.018 0.018 CD cord-010092-uftc8inx 5920 13 ) ) -RRB- cord-010092-uftc8inx 5920 14 . . . cord-010092-uftc8inx 5921 1 To to TO cord-010092-uftc8inx 5921 2 verify verify VB cord-010092-uftc8inx 5921 3 if if IN cord-010092-uftc8inx 5921 4 the the DT cord-010092-uftc8inx 5921 5 apoptotic apoptotic JJ cord-010092-uftc8inx 5921 6 signal signal NN cord-010092-uftc8inx 5921 7 , , , cord-010092-uftc8inx 5921 8 observed observe VBN cord-010092-uftc8inx 5921 9 with with IN cord-010092-uftc8inx 5921 10 phosphatidylserine phosphatidylserine NN cord-010092-uftc8inx 5921 11 , , , cord-010092-uftc8inx 5921 12 specifically specifically RB cord-010092-uftc8inx 5921 13 involved involve VBD cord-010092-uftc8inx 5921 14 the the DT cord-010092-uftc8inx 5921 15 intrinsic intrinsic JJ cord-010092-uftc8inx 5921 16 pathway pathway NN cord-010092-uftc8inx 5921 17 , , , cord-010092-uftc8inx 5921 18 the the DT cord-010092-uftc8inx 5921 19 MMP MMP NNP cord-010092-uftc8inx 5921 20 was be VBD cord-010092-uftc8inx 5921 21 analyzed analyze VBN cord-010092-uftc8inx 5921 22 as as IN cord-010092-uftc8inx 5921 23 a a DT cord-010092-uftc8inx 5921 24 marker marker NN cord-010092-uftc8inx 5921 25 of of IN cord-010092-uftc8inx 5921 26 alive alive JJ cord-010092-uftc8inx 5921 27 cells cell NNS cord-010092-uftc8inx 5921 28 . . . cord-010092-uftc8inx 5922 1 Interestingly interestingly RB cord-010092-uftc8inx 5922 2 , , , cord-010092-uftc8inx 5922 3 after after IN cord-010092-uftc8inx 5922 4 cold cold JJ cord-010092-uftc8inx 5922 5 storage storage NN cord-010092-uftc8inx 5922 6 a a DT cord-010092-uftc8inx 5922 7 decrease decrease NN cord-010092-uftc8inx 5922 8 of of IN cord-010092-uftc8inx 5922 9 the the DT cord-010092-uftc8inx 5922 10 MMP MMP NNP cord-010092-uftc8inx 5922 11 was be VBD cord-010092-uftc8inx 5922 12 observed observe VBN cord-010092-uftc8inx 5922 13 compared compare VBN cord-010092-uftc8inx 5922 14 to to IN cord-010092-uftc8inx 5922 15 RT RT NNP cord-010092-uftc8inx 5922 16 indicating indicate VBG cord-010092-uftc8inx 5922 17 the the DT cord-010092-uftc8inx 5922 18 activation activation NN cord-010092-uftc8inx 5922 19 of of IN cord-010092-uftc8inx 5922 20 the the DT cord-010092-uftc8inx 5922 21 intrinsic intrinsic JJ cord-010092-uftc8inx 5922 22 pathway pathway NN cord-010092-uftc8inx 5922 23 ( ( -LRB- cord-010092-uftc8inx 5922 24 Mean mean JJ cord-010092-uftc8inx 5922 25 fluorescence fluorescence NN cord-010092-uftc8inx 5922 26 intensity intensity NN cord-010092-uftc8inx 5922 27 TMRE TMRE NNP cord-010092-uftc8inx 5922 28 MeanAESEM MeanAESEM NNP cord-010092-uftc8inx 5922 29 : : : cord-010092-uftc8inx 5922 30 6.13 6.13 CD cord-010092-uftc8inx 5922 31 AE AE NNP cord-010092-uftc8inx 5922 32 1.89 1.89 CD cord-010092-uftc8inx 5922 33 vs. vs. NN cord-010092-uftc8inx 5922 34 18.53 18.53 CD cord-010092-uftc8inx 5922 35 AE AE NNP cord-010092-uftc8inx 5922 36 3.64 3.64 CD cord-010092-uftc8inx 5922 37 , , , cord-010092-uftc8inx 5922 38 P p NN cord-010092-uftc8inx 5922 39 = = SYM cord-010092-uftc8inx 5922 40 0.038 0.038 CD cord-010092-uftc8inx 5922 41 ) ) -RRB- cord-010092-uftc8inx 5922 42 . . . cord-010092-uftc8inx 5923 1 Accordingly accordingly RB cord-010092-uftc8inx 5923 2 , , , cord-010092-uftc8inx 5923 3 a a DT cord-010092-uftc8inx 5923 4 decrease decrease NN cord-010092-uftc8inx 5923 5 of of IN cord-010092-uftc8inx 5923 6 the the DT cord-010092-uftc8inx 5923 7 procaspase-3 procaspase-3 NNP cord-010092-uftc8inx 5923 8 level level NN cord-010092-uftc8inx 5923 9 after after IN cord-010092-uftc8inx 5923 10 cold cold JJ cord-010092-uftc8inx 5923 11 storage storage NN cord-010092-uftc8inx 5923 12 was be VBD cord-010092-uftc8inx 5923 13 detected detect VBN cord-010092-uftc8inx 5923 14 by by IN cord-010092-uftc8inx 5923 15 western western JJ cord-010092-uftc8inx 5923 16 blot blot NN cord-010092-uftc8inx 5923 17 analysis analysis NN cord-010092-uftc8inx 5923 18 . . . cord-010092-uftc8inx 5924 1 However however RB cord-010092-uftc8inx 5924 2 , , , cord-010092-uftc8inx 5924 3 when when WRB cord-010092-uftc8inx 5924 4 PLTs plt NNS cord-010092-uftc8inx 5924 5 were be VBD cord-010092-uftc8inx 5924 6 stored store VBN cord-010092-uftc8inx 5924 7 in in IN cord-010092-uftc8inx 5924 8 the the DT cord-010092-uftc8inx 5924 9 presence presence NN cord-010092-uftc8inx 5924 10 of of IN cord-010092-uftc8inx 5924 11 caspase-3 caspase-3 NNP cord-010092-uftc8inx 5924 12 inhibitor inhibitor NN cord-010092-uftc8inx 5924 13 a a DT cord-010092-uftc8inx 5924 14 significant significant JJ cord-010092-uftc8inx 5924 15 rescue rescue NN cord-010092-uftc8inx 5924 16 of of IN cord-010092-uftc8inx 5924 17 the the DT cord-010092-uftc8inx 5924 18 cold cold NN cord-010092-uftc8inx 5924 19 - - HYPH cord-010092-uftc8inx 5924 20 stored store VBN cord-010092-uftc8inx 5924 21 cells cell NNS cord-010092-uftc8inx 5924 22 viability viability NN cord-010092-uftc8inx 5924 23 was be VBD cord-010092-uftc8inx 5924 24 observed observe VBN cord-010092-uftc8inx 5924 25 ( ( -LRB- cord-010092-uftc8inx 5924 26 TMRE TMRE NNP cord-010092-uftc8inx 5924 27 staining stain VBG cord-010092-uftc8inx 5924 28 : : : cord-010092-uftc8inx 5924 29 % % NN cord-010092-uftc8inx 5924 30 alive alive JJ cord-010092-uftc8inx 5924 31 cells cell NNS cord-010092-uftc8inx 5925 1 meanAESEM meanAESEM NNP cord-010092-uftc8inx 5925 2 : : : cord-010092-uftc8inx 5926 1 74 74 CD cord-010092-uftc8inx 5926 2 AE AE NNP cord-010092-uftc8inx 5926 3 3 3 CD cord-010092-uftc8inx 5926 4 % % NN cord-010092-uftc8inx 5926 5 vs. vs. IN cord-010092-uftc8inx 5926 6 22 22 CD cord-010092-uftc8inx 5926 7 AE AE NNP cord-010092-uftc8inx 5926 8 3 3 CD cord-010092-uftc8inx 5926 9 % % NN cord-010092-uftc8inx 5926 10 , , , cord-010092-uftc8inx 5926 11 caspase caspase NN cord-010092-uftc8inx 5926 12 3 3 CD cord-010092-uftc8inx 5926 13 inhibitor inhibitor NN cord-010092-uftc8inx 5926 14 vs. vs. IN cord-010092-uftc8inx 5926 15 ionomycin ionomycin NN cord-010092-uftc8inx 5926 16 , , , cord-010092-uftc8inx 5926 17 P p NN cord-010092-uftc8inx 5926 18 = = SYM cord-010092-uftc8inx 5926 19 0.005 0.005 CD cord-010092-uftc8inx 5926 20 ) ) -RRB- cord-010092-uftc8inx 5926 21 . . . cord-010092-uftc8inx 5927 1 This this DT cord-010092-uftc8inx 5927 2 indicates indicate VBZ cord-010092-uftc8inx 5927 3 that that IN cord-010092-uftc8inx 5927 4 the the DT cord-010092-uftc8inx 5927 5 activation activation NN cord-010092-uftc8inx 5927 6 of of IN cord-010092-uftc8inx 5927 7 the the DT cord-010092-uftc8inx 5927 8 apoptotic apoptotic JJ cord-010092-uftc8inx 5927 9 pathway pathway NN cord-010092-uftc8inx 5927 10 , , , cord-010092-uftc8inx 5927 11 induced induce VBN cord-010092-uftc8inx 5927 12 during during IN cord-010092-uftc8inx 5927 13 cold cold JJ cord-010092-uftc8inx 5927 14 storage storage NN cord-010092-uftc8inx 5927 15 , , , cord-010092-uftc8inx 5927 16 can can MD cord-010092-uftc8inx 5927 17 be be VB cord-010092-uftc8inx 5927 18 prevented prevent VBN cord-010092-uftc8inx 5927 19 using use VBG cord-010092-uftc8inx 5927 20 caspase caspase NN cord-010092-uftc8inx 5927 21 inhibitor inhibitor NN cord-010092-uftc8inx 5927 22 Summary Summary NNP cord-010092-uftc8inx 5927 23 / / SYM cord-010092-uftc8inx 5927 24 Conclusions Conclusions NNPS cord-010092-uftc8inx 5927 25 : : : cord-010092-uftc8inx 5928 1 Our -PRON- PRP$ cord-010092-uftc8inx 5928 2 results result NNS cord-010092-uftc8inx 5928 3 show show VBP cord-010092-uftc8inx 5928 4 that that IN cord-010092-uftc8inx 5928 5 the the DT cord-010092-uftc8inx 5928 6 reduction reduction NN cord-010092-uftc8inx 5928 7 of of IN cord-010092-uftc8inx 5928 8 cold cold NN cord-010092-uftc8inx 5928 9 - - HYPH cord-010092-uftc8inx 5928 10 stored store VBN cord-010092-uftc8inx 5928 11 PLT PLT NNP cord-010092-uftc8inx 5928 12 viability viability NN cord-010092-uftc8inx 5928 13 can can MD cord-010092-uftc8inx 5928 14 be be VB cord-010092-uftc8inx 5928 15 prevented prevent VBN cord-010092-uftc8inx 5928 16 by by IN cord-010092-uftc8inx 5928 17 a a DT cord-010092-uftc8inx 5928 18 specific specific JJ cord-010092-uftc8inx 5928 19 caspase caspase JJ cord-010092-uftc8inx 5928 20 inhibitor inhibitor NN cord-010092-uftc8inx 5928 21 . . . cord-010092-uftc8inx 5929 1 Consequently consequently RB cord-010092-uftc8inx 5929 2 , , , cord-010092-uftc8inx 5929 3 cold cold JJ cord-010092-uftc8inx 5929 4 storage storage NN cord-010092-uftc8inx 5929 5 , , , cord-010092-uftc8inx 5929 6 associated associate VBN cord-010092-uftc8inx 5929 7 with with IN cord-010092-uftc8inx 5929 8 a a DT cord-010092-uftc8inx 5929 9 better well JJR cord-010092-uftc8inx 5929 10 PLT PLT NNP cord-010092-uftc8inx 5929 11 functionality functionality NN cord-010092-uftc8inx 5929 12 , , , cord-010092-uftc8inx 5929 13 may may MD cord-010092-uftc8inx 5929 14 become become VB cord-010092-uftc8inx 5929 15 an an DT cord-010092-uftc8inx 5929 16 efficient efficient JJ cord-010092-uftc8inx 5929 17 strategy strategy NN cord-010092-uftc8inx 5929 18 for for IN cord-010092-uftc8inx 5929 19 APC APC NNP cord-010092-uftc8inx 5929 20 storage storage NN cord-010092-uftc8inx 5929 21 in in IN cord-010092-uftc8inx 5929 22 combination combination NN cord-010092-uftc8inx 5929 23 with with IN cord-010092-uftc8inx 5929 24 apoptotic apoptotic JJ cord-010092-uftc8inx 5929 25 inhibitors inhibitor NNS cord-010092-uftc8inx 5930 1 Background background NN cord-010092-uftc8inx 5930 2 : : : cord-010092-uftc8inx 5931 1 Gamma gamma NN cord-010092-uftc8inx 5931 2 - - HYPH cord-010092-uftc8inx 5931 3 irradiation irradiation NN cord-010092-uftc8inx 5931 4 is be VBZ cord-010092-uftc8inx 5931 5 used use VBN cord-010092-uftc8inx 5931 6 to to TO cord-010092-uftc8inx 5931 7 treat treat VB cord-010092-uftc8inx 5931 8 red red JJ cord-010092-uftc8inx 5931 9 blood blood NN cord-010092-uftc8inx 5931 10 cell cell NN cord-010092-uftc8inx 5931 11 ( ( -LRB- cord-010092-uftc8inx 5931 12 RBC RBC NNP cord-010092-uftc8inx 5931 13 ) ) -RRB- cord-010092-uftc8inx 5931 14 concentrates concentrate VBZ cord-010092-uftc8inx 5931 15 ( ( -LRB- cord-010092-uftc8inx 5931 16 RCCs rccs NN cord-010092-uftc8inx 5931 17 ) ) -RRB- cord-010092-uftc8inx 5931 18 for for IN cord-010092-uftc8inx 5931 19 patients patient NNS cord-010092-uftc8inx 5931 20 who who WP cord-010092-uftc8inx 5931 21 are be VBP cord-010092-uftc8inx 5931 22 immunosuppressed immunosuppressed JJ cord-010092-uftc8inx 5931 23 . . . cord-010092-uftc8inx 5932 1 This this DT cord-010092-uftc8inx 5932 2 treatment treatment NN cord-010092-uftc8inx 5932 3 is be VBZ cord-010092-uftc8inx 5932 4 known know VBN cord-010092-uftc8inx 5932 5 to to TO cord-010092-uftc8inx 5932 6 damage damage VB cord-010092-uftc8inx 5932 7 RBCs rbc NNS cord-010092-uftc8inx 5932 8 and and CC cord-010092-uftc8inx 5932 9 to to TO cord-010092-uftc8inx 5932 10 increase increase VB cord-010092-uftc8inx 5932 11 storage storage NN cord-010092-uftc8inx 5932 12 lesions lesion NNS cord-010092-uftc8inx 5932 13 . . . cord-010092-uftc8inx 5933 1 One one CD cord-010092-uftc8inx 5933 2 of of IN cord-010092-uftc8inx 5933 3 the the DT cord-010092-uftc8inx 5933 4 causes cause NNS cord-010092-uftc8inx 5933 5 of of IN cord-010092-uftc8inx 5933 6 the the DT cord-010092-uftc8inx 5933 7 storage storage NN cord-010092-uftc8inx 5933 8 lesions lesion NNS cord-010092-uftc8inx 5933 9 is be VBZ cord-010092-uftc8inx 5933 10 the the DT cord-010092-uftc8inx 5933 11 presence presence NN cord-010092-uftc8inx 5933 12 of of IN cord-010092-uftc8inx 5933 13 oxygen oxygen NN cord-010092-uftc8inx 5933 14 . . . cord-010092-uftc8inx 5934 1 Several several JJ cord-010092-uftc8inx 5934 2 studies study NNS cord-010092-uftc8inx 5934 3 have have VBP cord-010092-uftc8inx 5934 4 shown show VBN cord-010092-uftc8inx 5934 5 , , , cord-010092-uftc8inx 5934 6 based base VBN cord-010092-uftc8inx 5934 7 on on IN cord-010092-uftc8inx 5934 8 different different JJ cord-010092-uftc8inx 5934 9 strategies strategy NNS cord-010092-uftc8inx 5934 10 to to TO cord-010092-uftc8inx 5934 11 reduce reduce VB cord-010092-uftc8inx 5934 12 O o CD cord-010092-uftc8inx 5934 13 2 2 CD cord-010092-uftc8inx 5934 14 , , , cord-010092-uftc8inx 5934 15 a a DT cord-010092-uftc8inx 5934 16 reduction reduction NN cord-010092-uftc8inx 5934 17 of of IN cord-010092-uftc8inx 5934 18 storage storage NN cord-010092-uftc8inx 5934 19 lesions lesion NNS cord-010092-uftc8inx 5934 20 related relate VBN cord-010092-uftc8inx 5934 21 to to IN cord-010092-uftc8inx 5934 22 metabolism metabolism NN cord-010092-uftc8inx 5934 23 , , , cord-010092-uftc8inx 5934 24 protein protein NN cord-010092-uftc8inx 5934 25 modifications modification NNS cord-010092-uftc8inx 5934 26 and and CC cord-010092-uftc8inx 5934 27 cell cell NN cord-010092-uftc8inx 5934 28 morphology morphology NN cord-010092-uftc8inx 5934 29 . . . cord-010092-uftc8inx 5935 1 Aims aim VBZ cord-010092-uftc8inx 5935 2 : : : cord-010092-uftc8inx 5936 1 The the DT cord-010092-uftc8inx 5936 2 present present JJ cord-010092-uftc8inx 5936 3 research research NN cord-010092-uftc8inx 5936 4 work work NN cord-010092-uftc8inx 5936 5 investigated investigate VBD cord-010092-uftc8inx 5936 6 the the DT cord-010092-uftc8inx 5936 7 effect effect NN cord-010092-uftc8inx 5936 8 of of IN cord-010092-uftc8inx 5936 9 gamma gamma NN cord-010092-uftc8inx 5936 10 - - HYPH cord-010092-uftc8inx 5936 11 irradiation irradiation NN cord-010092-uftc8inx 5936 12 on on IN cord-010092-uftc8inx 5936 13 RCCs rcc NNS cord-010092-uftc8inx 5936 14 stored store VBN cord-010092-uftc8inx 5936 15 under under IN cord-010092-uftc8inx 5936 16 normal normal JJ cord-010092-uftc8inx 5936 17 condition condition NN cord-010092-uftc8inx 5936 18 and and CC cord-010092-uftc8inx 5936 19 hypoxia hypoxia NN cord-010092-uftc8inx 5936 20 / / SYM cord-010092-uftc8inx 5936 21 hypocapnia hypocapnia NNS cord-010092-uftc8inx 5936 22 . . . cord-010092-uftc8inx 5937 1 Methods method NNS cord-010092-uftc8inx 5937 2 : : : cord-010092-uftc8inx 5937 3 Saturation saturation NN cord-010092-uftc8inx 5937 4 of of IN cord-010092-uftc8inx 5937 5 O o NN cord-010092-uftc8inx 5937 6 2 2 CD cord-010092-uftc8inx 5937 7 ( ( -LRB- cord-010092-uftc8inx 5937 8 sO so RB cord-010092-uftc8inx 5937 9 2 2 CD cord-010092-uftc8inx 5937 10 ) ) -RRB- cord-010092-uftc8inx 5938 1 -and -and : cord-010092-uftc8inx 5938 2 ABO ABO NNP cord-010092-uftc8inx 5938 3 - - HYPH cord-010092-uftc8inx 5938 4 matched match VBN cord-010092-uftc8inx 5938 5 RCCs rccs NN cord-010092-uftc8inx 5938 6 from from IN cord-010092-uftc8inx 5938 7 whole whole JJ cord-010092-uftc8inx 5938 8 blood blood NN cord-010092-uftc8inx 5938 9 donations donation NNS cord-010092-uftc8inx 5938 10 , , , cord-010092-uftc8inx 5938 11 leukoreduced leukoreduce VBN cord-010092-uftc8inx 5938 12 and and CC cord-010092-uftc8inx 5938 13 prepared prepare VBN cord-010092-uftc8inx 5938 14 in in IN cord-010092-uftc8inx 5938 15 PAGGSM PAGGSM NNP cord-010092-uftc8inx 5938 16 ( ( -LRB- cord-010092-uftc8inx 5938 17 Macopharma Macopharma NNP cord-010092-uftc8inx 5938 18 , , , cord-010092-uftc8inx 5938 19 France France NNP cord-010092-uftc8inx 5938 20 ) ) -RRB- cord-010092-uftc8inx 5938 21 were be VBD cord-010092-uftc8inx 5938 22 pooled pool VBN cord-010092-uftc8inx 5938 23 and and CC cord-010092-uftc8inx 5938 24 split split VBD cord-010092-uftc8inx 5938 25 in in IN cord-010092-uftc8inx 5938 26 two two CD cord-010092-uftc8inx 5938 27 identical identical JJ cord-010092-uftc8inx 5938 28 RCCs rcc NNS cord-010092-uftc8inx 5938 29 within within IN cord-010092-uftc8inx 5938 30 24 24 CD cord-010092-uftc8inx 5938 31 h h NN cord-010092-uftc8inx 5938 32 post post NN cord-010092-uftc8inx 5938 33 - - NN cord-010092-uftc8inx 5938 34 donation donation NN cord-010092-uftc8inx 5938 35 . . . cord-010092-uftc8inx 5939 1 One one CD cord-010092-uftc8inx 5939 2 bag bag NN cord-010092-uftc8inx 5939 3 ( ( -LRB- cord-010092-uftc8inx 5939 4 treated treat VBN cord-010092-uftc8inx 5939 5 ) ) -RRB- cord-010092-uftc8inx 5939 6 was be VBD cord-010092-uftc8inx 5939 7 submitted submit VBN cord-010092-uftc8inx 5939 8 to to IN cord-010092-uftc8inx 5939 9 oxygen oxygen NN cord-010092-uftc8inx 5939 10 and and CC cord-010092-uftc8inx 5939 11 carbon carbon NN cord-010092-uftc8inx 5939 12 dioxide dioxide NN cord-010092-uftc8inx 5939 13 adsorption adsorption NN cord-010092-uftc8inx 5939 14 ( ( -LRB- cord-010092-uftc8inx 5939 15 oxygen oxygen NN cord-010092-uftc8inx 5939 16 reduction reduction NN cord-010092-uftc8inx 5939 17 bag bag NN cord-010092-uftc8inx 5939 18 , , , cord-010092-uftc8inx 5939 19 Hemanext Hemanext NNP cord-010092-uftc8inx 5939 20 , , , cord-010092-uftc8inx 5939 21 USA USA NNP cord-010092-uftc8inx 5939 22 ) ) -RRB- cord-010092-uftc8inx 5939 23 for for IN cord-010092-uftc8inx 5939 24 3 3 CD cord-010092-uftc8inx 5939 25 h h NN cord-010092-uftc8inx 5939 26 on on IN cord-010092-uftc8inx 5939 27 an an DT cord-010092-uftc8inx 5939 28 orbital orbital JJ cord-010092-uftc8inx 5939 29 shaker shaker NN cord-010092-uftc8inx 5939 30 ( ( -LRB- cord-010092-uftc8inx 5939 31 50 50 CD cord-010092-uftc8inx 5939 32 rpm rpm NN cord-010092-uftc8inx 5939 33 ) ) -RRB- cord-010092-uftc8inx 5939 34 at at IN cord-010092-uftc8inx 5939 35 22 22 CD cord-010092-uftc8inx 5939 36 ° ° NN cord-010092-uftc8inx 5939 37 CAE2 CAE2 NNP cord-010092-uftc8inx 5939 38 and and CC cord-010092-uftc8inx 5939 39 then then RB cord-010092-uftc8inx 5939 40 transferred transfer VBD cord-010092-uftc8inx 5939 41 to to IN cord-010092-uftc8inx 5939 42 a a DT cord-010092-uftc8inx 5939 43 storage storage NN cord-010092-uftc8inx 5939 44 bag bag NN cord-010092-uftc8inx 5939 45 impermeable impermeable JJ cord-010092-uftc8inx 5939 46 to to IN cord-010092-uftc8inx 5939 47 gas gas NN cord-010092-uftc8inx 5939 48 . . . cord-010092-uftc8inx 5940 1 The the DT cord-010092-uftc8inx 5940 2 other other JJ cord-010092-uftc8inx 5940 3 one one NN cord-010092-uftc8inx 5940 4 ( ( -LRB- cord-010092-uftc8inx 5940 5 control control NN cord-010092-uftc8inx 5940 6 ) ) -RRB- cord-010092-uftc8inx 5940 7 was be VBD cord-010092-uftc8inx 5940 8 left leave VBN cord-010092-uftc8inx 5940 9 as as IN cord-010092-uftc8inx 5940 10 it -PRON- PRP cord-010092-uftc8inx 5940 11 is be VBZ cord-010092-uftc8inx 5940 12 . . . cord-010092-uftc8inx 5941 1 The the DT cord-010092-uftc8inx 5941 2 two two CD cord-010092-uftc8inx 5941 3 bags bag NNS cord-010092-uftc8inx 5941 4 were be VBD cord-010092-uftc8inx 5941 5 then then RB cord-010092-uftc8inx 5941 6 stored store VBN cord-010092-uftc8inx 5941 7 at at IN cord-010092-uftc8inx 5941 8 4 4 CD cord-010092-uftc8inx 5941 9 ° ° NN cord-010092-uftc8inx 5941 10 C c NN cord-010092-uftc8inx 5941 11 . . . cord-010092-uftc8inx 5942 1 A a DT cord-010092-uftc8inx 5942 2 g g NN cord-010092-uftc8inx 5942 3 - - HYPH cord-010092-uftc8inx 5942 4 irradiation irradiation NN cord-010092-uftc8inx 5942 5 treatment treatment NN cord-010092-uftc8inx 5942 6 ( ( -LRB- cord-010092-uftc8inx 5942 7 25 25 CD cord-010092-uftc8inx 5942 8 Gy Gy NNP cord-010092-uftc8inx 5942 9 , , , cord-010092-uftc8inx 5942 10 Gammacell Gammacell NNP cord-010092-uftc8inx 5942 11 3000 3000 CD cord-010092-uftc8inx 5942 12 Elan Elan NNP cord-010092-uftc8inx 5942 13 , , , cord-010092-uftc8inx 5942 14 Theratronics Theratronics NNP cord-010092-uftc8inx 5942 15 ) ) -RRB- cord-010092-uftc8inx 5942 16 was be VBD cord-010092-uftc8inx 5942 17 applied apply VBN cord-010092-uftc8inx 5942 18 at at IN cord-010092-uftc8inx 5942 19 day day NN cord-010092-uftc8inx 5942 20 2 2 CD cord-010092-uftc8inx 5942 21 or or CC cord-010092-uftc8inx 5942 22 14 14 CD cord-010092-uftc8inx 5942 23 and and CC cord-010092-uftc8inx 5942 24 the the DT cord-010092-uftc8inx 5942 25 RCCs rccs NN cord-010092-uftc8inx 5942 26 ( ( -LRB- cord-010092-uftc8inx 5942 27 expiry expiry NN cord-010092-uftc8inx 5942 28 dates date NNS cord-010092-uftc8inx 5942 29 at at IN cord-010092-uftc8inx 5942 30 day day NN cord-010092-uftc8inx 5942 31 16 16 CD cord-010092-uftc8inx 5942 32 or or CC cord-010092-uftc8inx 5942 33 day day NN cord-010092-uftc8inx 5942 34 28 28 CD cord-010092-uftc8inx 5942 35 , , , cord-010092-uftc8inx 5942 36 respectively respectively RB cord-010092-uftc8inx 5942 37 ) ) -RRB- cord-010092-uftc8inx 5942 38 were be VBD cord-010092-uftc8inx 5942 39 stored store VBN cord-010092-uftc8inx 5942 40 until until IN cord-010092-uftc8inx 5942 41 day day NN cord-010092-uftc8inx 5942 42 43 43 CD cord-010092-uftc8inx 5942 43 . . . cord-010092-uftc8inx 5943 1 Hematological Hematological NNP cord-010092-uftc8inx 5943 2 parameters parameter NNS cord-010092-uftc8inx 5943 3 , , , cord-010092-uftc8inx 5943 4 glycolytic glycolytic JJ cord-010092-uftc8inx 5943 5 metabolites metabolite NNS cord-010092-uftc8inx 5943 6 , , , cord-010092-uftc8inx 5943 7 extracellular extracellular JJ cord-010092-uftc8inx 5943 8 potassium potassium NN cord-010092-uftc8inx 5943 9 level level NN cord-010092-uftc8inx 5943 10 , , , cord-010092-uftc8inx 5943 11 antioxidant antioxidant JJ cord-010092-uftc8inx 5943 12 power power NN cord-010092-uftc8inx 5943 13 , , , cord-010092-uftc8inx 5943 14 morphology morphology NN cord-010092-uftc8inx 5943 15 and and CC cord-010092-uftc8inx 5943 16 deformability deformability NN cord-010092-uftc8inx 5943 17 were be VBD cord-010092-uftc8inx 5943 18 measured measure VBN cord-010092-uftc8inx 5943 19 . . . cord-010092-uftc8inx 5944 1 Results result NNS cord-010092-uftc8inx 5944 2 : : : cord-010092-uftc8inx 5945 1 Starting start VBG cord-010092-uftc8inx 5945 2 sO so RB cord-010092-uftc8inx 5945 3 2 2 CD cord-010092-uftc8inx 5945 4 values value NNS cord-010092-uftc8inx 5945 5 were be VBD cord-010092-uftc8inx 5945 6 of of IN cord-010092-uftc8inx 5945 7 63.7%AE18.4 63.7%ae18.4 CD cord-010092-uftc8inx 5946 1 ( ( -LRB- cord-010092-uftc8inx 5946 2 n n NN cord-010092-uftc8inx 5946 3 = = SYM cord-010092-uftc8inx 5946 4 12 12 CD cord-010092-uftc8inx 5946 5 ) ) -RRB- cord-010092-uftc8inx 5946 6 in in IN cord-010092-uftc8inx 5946 7 control control NN cord-010092-uftc8inx 5946 8 and and CC cord-010092-uftc8inx 5946 9 of of IN cord-010092-uftc8inx 5946 10 20.8%AE9.8 20.8%ae9.8 CD cord-010092-uftc8inx 5946 11 ( ( -LRB- cord-010092-uftc8inx 5946 12 n n NN cord-010092-uftc8inx 5946 13 = = SYM cord-010092-uftc8inx 5946 14 12 12 CD cord-010092-uftc8inx 5946 15 ) ) -RRB- cord-010092-uftc8inx 5946 16 in in IN cord-010092-uftc8inx 5946 17 treated treat VBN cord-010092-uftc8inx 5946 18 bags bag NNS cord-010092-uftc8inx 5946 19 , , , cord-010092-uftc8inx 5946 20 and and CC cord-010092-uftc8inx 5946 21 reached reach VBD cord-010092-uftc8inx 5946 22 90.8%AE9.1 90.8%ae9.1 CD cord-010092-uftc8inx 5946 23 and and CC cord-010092-uftc8inx 5946 24 6.6%AE5.9 6.6%ae5.9 CD cord-010092-uftc8inx 5946 25 at at IN cord-010092-uftc8inx 5946 26 day day NN cord-010092-uftc8inx 5946 27 43 43 CD cord-010092-uftc8inx 5946 28 , , , cord-010092-uftc8inx 5946 29 respectively respectively RB cord-010092-uftc8inx 5946 30 . . . cord-010092-uftc8inx 5947 1 As as IN cord-010092-uftc8inx 5947 2 expected expect VBN cord-010092-uftc8inx 5947 3 , , , cord-010092-uftc8inx 5947 4 an an DT cord-010092-uftc8inx 5947 5 increase increase NN cord-010092-uftc8inx 5947 6 in in IN cord-010092-uftc8inx 5947 7 glycolysis glycolysis NN cord-010092-uftc8inx 5947 8 rate rate NN cord-010092-uftc8inx 5947 9 was be VBD cord-010092-uftc8inx 5947 10 observed observe VBN cord-010092-uftc8inx 5947 11 during during IN cord-010092-uftc8inx 5947 12 deoxygenation deoxygenation NN cord-010092-uftc8inx 5947 13 without without IN cord-010092-uftc8inx 5947 14 any any DT cord-010092-uftc8inx 5947 15 influence influence NN cord-010092-uftc8inx 5947 16 from from IN cord-010092-uftc8inx 5947 17 the the DT cord-010092-uftc8inx 5947 18 irradiation irradiation NN cord-010092-uftc8inx 5947 19 . . . cord-010092-uftc8inx 5948 1 Potassium potassium NN cord-010092-uftc8inx 5948 2 levels level NNS cord-010092-uftc8inx 5948 3 were be VBD cord-010092-uftc8inx 5948 4 identical identical JJ cord-010092-uftc8inx 5948 5 in in IN cord-010092-uftc8inx 5948 6 treated treat VBN cord-010092-uftc8inx 5948 7 and and CC cord-010092-uftc8inx 5948 8 control control NN cord-010092-uftc8inx 5948 9 , , , cord-010092-uftc8inx 5948 10 and and CC cord-010092-uftc8inx 5948 11 reached reach VBD cord-010092-uftc8inx 5948 12 around around RB cord-010092-uftc8inx 5948 13 70 70 CD cord-010092-uftc8inx 5948 14 mM mm CD cord-010092-uftc8inx 5948 15 at at IN cord-010092-uftc8inx 5948 16 expiry expiry NN cord-010092-uftc8inx 5948 17 with with IN cord-010092-uftc8inx 5948 18 an an DT cord-010092-uftc8inx 5948 19 irradiation irradiation NN cord-010092-uftc8inx 5948 20 - - HYPH cord-010092-uftc8inx 5948 21 dependent dependent JJ cord-010092-uftc8inx 5948 22 kinetic kinetic JJ cord-010092-uftc8inx 5948 23 release release NN cord-010092-uftc8inx 5948 24 . . . cord-010092-uftc8inx 5949 1 Antioxidant antioxidant JJ cord-010092-uftc8inx 5949 2 power power NN cord-010092-uftc8inx 5949 3 and and CC cord-010092-uftc8inx 5949 4 deformability deformability NN cord-010092-uftc8inx 5949 5 were be VBD cord-010092-uftc8inx 5949 6 identical identical JJ cord-010092-uftc8inx 5949 7 in in IN cord-010092-uftc8inx 5949 8 both both DT cord-010092-uftc8inx 5949 9 conditions condition NNS cord-010092-uftc8inx 5949 10 . . . cord-010092-uftc8inx 5950 1 No no DT cord-010092-uftc8inx 5950 2 difference difference NN cord-010092-uftc8inx 5950 3 in in IN cord-010092-uftc8inx 5950 4 hemolysis hemolysis NN cord-010092-uftc8inx 5950 5 was be VBD cord-010092-uftc8inx 5950 6 observed observe VBN cord-010092-uftc8inx 5950 7 after after IN cord-010092-uftc8inx 5950 8 irradiation irradiation NN cord-010092-uftc8inx 5950 9 on on IN cord-010092-uftc8inx 5950 10 day day NN cord-010092-uftc8inx 5950 11 2 2 CD cord-010092-uftc8inx 5950 12 and and CC cord-010092-uftc8inx 5950 13 the the DT cord-010092-uftc8inx 5950 14 values value NNS cord-010092-uftc8inx 5950 15 stayed stay VBD cord-010092-uftc8inx 5950 16 equivalent equivalent JJ cord-010092-uftc8inx 5950 17 through through IN cord-010092-uftc8inx 5950 18 end end NN cord-010092-uftc8inx 5950 19 of of IN cord-010092-uftc8inx 5950 20 storage storage NN cord-010092-uftc8inx 5950 21 ( ( -LRB- cord-010092-uftc8inx 5950 22 at at IN cord-010092-uftc8inx 5950 23 day day NN cord-010092-uftc8inx 5950 24 16 16 CD cord-010092-uftc8inx 5950 25 , , , cord-010092-uftc8inx 5950 26 hemolysis hemolysis NN cord-010092-uftc8inx 5950 27 ( ( -LRB- cord-010092-uftc8inx 5950 28 control control NN cord-010092-uftc8inx 5950 29 ) ) -RRB- cord-010092-uftc8inx 5950 30 = = NFP cord-010092-uftc8inx 5951 1 0.37%AE0.24 0.37%AE0.24 NNP cord-010092-uftc8inx 5951 2 , , , cord-010092-uftc8inx 5951 3 hemolysis hemolysis NN cord-010092-uftc8inx 5951 4 ( ( -LRB- cord-010092-uftc8inx 5951 5 treated treat VBN cord-010092-uftc8inx 5951 6 ) ) -RRB- cord-010092-uftc8inx 5951 7 = = . cord-010092-uftc8inx 5952 1 0.34%AE 0.34%ae CD cord-010092-uftc8inx 5952 2 0.15 0.15 CD cord-010092-uftc8inx 5952 3 , , , cord-010092-uftc8inx 5953 1 P p NN cord-010092-uftc8inx 5953 2 - - HYPH cord-010092-uftc8inx 5953 3 value value NN cord-010092-uftc8inx 5953 4 > > XX cord-010092-uftc8inx 5953 5 0.9999 0.9999 CD cord-010092-uftc8inx 5953 6 ) ) -RRB- cord-010092-uftc8inx 5953 7 . . . cord-010092-uftc8inx 5954 1 When when WRB cord-010092-uftc8inx 5954 2 irradiated irradiate VBN cord-010092-uftc8inx 5954 3 at at IN cord-010092-uftc8inx 5954 4 day day NN cord-010092-uftc8inx 5954 5 14 14 CD cord-010092-uftc8inx 5954 6 , , , cord-010092-uftc8inx 5954 7 hemolysis hemolysis NN cord-010092-uftc8inx 5954 8 was be VBD cord-010092-uftc8inx 5954 9 lower low JJR cord-010092-uftc8inx 5955 1 ( ( -LRB- cord-010092-uftc8inx 5955 2 P p NN cord-010092-uftc8inx 5955 3 - - HYPH cord-010092-uftc8inx 5955 4 value value NN cord-010092-uftc8inx 5955 5 = = SYM cord-010092-uftc8inx 5955 6 0.033 0.033 CD cord-010092-uftc8inx 5955 7 ) ) -RRB- cord-010092-uftc8inx 5955 8 in in IN cord-010092-uftc8inx 5955 9 treated treat VBN cord-010092-uftc8inx 5955 10 RCCs rcc NNS cord-010092-uftc8inx 5955 11 at at IN cord-010092-uftc8inx 5955 12 the the DT cord-010092-uftc8inx 5955 13 end end NN cord-010092-uftc8inx 5955 14 of of IN cord-010092-uftc8inx 5955 15 storage storage NN cord-010092-uftc8inx 5955 16 ( ( -LRB- cord-010092-uftc8inx 5955 17 day day NN cord-010092-uftc8inx 5955 18 28 28 CD cord-010092-uftc8inx 5955 19 , , , cord-010092-uftc8inx 5955 20 0.67%AE0.16 0.67%ae0.16 CD cord-010092-uftc8inx 5955 21 ) ) -RRB- cord-010092-uftc8inx 5955 22 compared compare VBN cord-010092-uftc8inx 5955 23 to to IN cord-010092-uftc8inx 5955 24 control control NN cord-010092-uftc8inx 5955 25 ( ( -LRB- cord-010092-uftc8inx 5955 26 1.06%AE0.33 1.06%ae0.33 CD cord-010092-uftc8inx 5955 27 ) ) -RRB- cord-010092-uftc8inx 5955 28 . . . cord-010092-uftc8inx 5956 1 Seven seven CD cord-010092-uftc8inx 5956 2 days day NNS cord-010092-uftc8inx 5956 3 post post NN cord-010092-uftc8inx 5956 4 - - NN cord-010092-uftc8inx 5956 5 irradiation irradiation NN cord-010092-uftc8inx 5956 6 , , , cord-010092-uftc8inx 5956 7 two two CD cord-010092-uftc8inx 5956 8 - - HYPH cord-010092-uftc8inx 5956 9 third third NN cord-010092-uftc8inx 5956 10 of of IN cord-010092-uftc8inx 5956 11 the the DT cord-010092-uftc8inx 5956 12 control control NN cord-010092-uftc8inx 5956 13 RCCs rccs NN cord-010092-uftc8inx 5956 14 were be VBD cord-010092-uftc8inx 5956 15 above above IN cord-010092-uftc8inx 5956 16 the the DT cord-010092-uftc8inx 5956 17 limit limit NN cord-010092-uftc8inx 5956 18 of of IN cord-010092-uftc8inx 5956 19 0.8 0.8 CD cord-010092-uftc8inx 5956 20 % % NN cord-010092-uftc8inx 5956 21 whereas whereas IN cord-010092-uftc8inx 5956 22 all all PDT cord-010092-uftc8inx 5956 23 the the DT cord-010092-uftc8inx 5956 24 treated treat VBN cord-010092-uftc8inx 5956 25 RCCs rcc NNS cord-010092-uftc8inx 5956 26 remain remain VBP cord-010092-uftc8inx 5956 27 below below IN cord-010092-uftc8inx 5956 28 the the DT cord-010092-uftc8inx 5956 29 limit limit NN cord-010092-uftc8inx 5956 30 . . . cord-010092-uftc8inx 5957 1 Quantification quantification NN cord-010092-uftc8inx 5957 2 of of IN cord-010092-uftc8inx 5957 3 microvesicles microvesicle NNS cord-010092-uftc8inx 5957 4 and and CC cord-010092-uftc8inx 5957 5 morphological morphological JJ cord-010092-uftc8inx 5957 6 analysis analysis NN cord-010092-uftc8inx 5957 7 confirmed confirm VBD cord-010092-uftc8inx 5957 8 these these DT cord-010092-uftc8inx 5957 9 data datum NNS cord-010092-uftc8inx 5957 10 . . . cord-010092-uftc8inx 5958 1 Summary Summary NNP cord-010092-uftc8inx 5958 2 / / SYM cord-010092-uftc8inx 5958 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 5958 4 : : : cord-010092-uftc8inx 5959 1 The the DT cord-010092-uftc8inx 5959 2 storage storage NN cord-010092-uftc8inx 5959 3 under under IN cord-010092-uftc8inx 5959 4 hypoxia hypoxia NN cord-010092-uftc8inx 5959 5 has have VBZ cord-010092-uftc8inx 5959 6 a a DT cord-010092-uftc8inx 5959 7 beneficial beneficial JJ cord-010092-uftc8inx 5959 8 effect effect NN cord-010092-uftc8inx 5959 9 on on IN cord-010092-uftc8inx 5959 10 RBC RBC NNP cord-010092-uftc8inx 5959 11 storage storage NN cord-010092-uftc8inx 5959 12 thanks thank NNS cord-010092-uftc8inx 5959 13 to to IN cord-010092-uftc8inx 5959 14 a a DT cord-010092-uftc8inx 5959 15 decrease decrease NN cord-010092-uftc8inx 5959 16 in in IN cord-010092-uftc8inx 5959 17 O o NN cord-010092-uftc8inx 5959 18 2 2 CD cord-010092-uftc8inx 5959 19 content content NN cord-010092-uftc8inx 5959 20 and and CC cord-010092-uftc8inx 5959 21 to to IN cord-010092-uftc8inx 5959 22 an an DT cord-010092-uftc8inx 5959 23 improvement improvement NN cord-010092-uftc8inx 5959 24 of of IN cord-010092-uftc8inx 5959 25 metabolism metabolism NN cord-010092-uftc8inx 5959 26 . . . cord-010092-uftc8inx 5960 1 This this DT cord-010092-uftc8inx 5960 2 benefit benefit NN cord-010092-uftc8inx 5960 3 provided provide VBD cord-010092-uftc8inx 5960 4 equivalent equivalent JJ cord-010092-uftc8inx 5960 5 storage storage NN cord-010092-uftc8inx 5960 6 when when WRB cord-010092-uftc8inx 5960 7 RCCs rcc NNS cord-010092-uftc8inx 5960 8 were be VBD cord-010092-uftc8inx 5960 9 irradiated irradiate VBN cord-010092-uftc8inx 5960 10 at at IN cord-010092-uftc8inx 5960 11 day day NN cord-010092-uftc8inx 5960 12 2 2 CD cord-010092-uftc8inx 5960 13 and and CC cord-010092-uftc8inx 5960 14 was be VBD cord-010092-uftc8inx 5960 15 an an DT cord-010092-uftc8inx 5960 16 advantage advantage NN cord-010092-uftc8inx 5960 17 when when WRB cord-010092-uftc8inx 5960 18 irradiated irradiate VBN cord-010092-uftc8inx 5960 19 at at IN cord-010092-uftc8inx 5960 20 day day NN cord-010092-uftc8inx 5960 21 14 14 CD cord-010092-uftc8inx 5960 22 . . . cord-010092-uftc8inx 5961 1 Importantly importantly RB cord-010092-uftc8inx 5961 2 , , , cord-010092-uftc8inx 5961 3 the the DT cord-010092-uftc8inx 5961 4 results result NNS cord-010092-uftc8inx 5961 5 show show VBP cord-010092-uftc8inx 5961 6 that that IN cord-010092-uftc8inx 5961 7 combining combine VBG cord-010092-uftc8inx 5961 8 irradiation irradiation NN cord-010092-uftc8inx 5961 9 with with IN cord-010092-uftc8inx 5961 10 hypoxia hypoxia NN cord-010092-uftc8inx 5961 11 / / SYM cord-010092-uftc8inx 5961 12 hypocapnia hypocapnia NNP cord-010092-uftc8inx 5961 13 retained retain VBD cord-010092-uftc8inx 5961 14 the the DT cord-010092-uftc8inx 5961 15 improved improved JJ cord-010092-uftc8inx 5961 16 hemolysis hemolysis NN cord-010092-uftc8inx 5961 17 profile profile NN cord-010092-uftc8inx 5961 18 of of IN cord-010092-uftc8inx 5961 19 O o NN cord-010092-uftc8inx 5961 20 2 2 CD cord-010092-uftc8inx 5961 21 depleted deplete VBD cord-010092-uftc8inx 5961 22 RBC RBC NNP cord-010092-uftc8inx 5961 23 . . . cord-010092-uftc8inx 5962 1 In in IN cord-010092-uftc8inx 5962 2 summary summary NN cord-010092-uftc8inx 5962 3 , , , cord-010092-uftc8inx 5962 4 the the DT cord-010092-uftc8inx 5962 5 reduction reduction NN cord-010092-uftc8inx 5962 6 of of IN cord-010092-uftc8inx 5962 7 O o NN cord-010092-uftc8inx 5962 8 2 2 CD cord-010092-uftc8inx 5962 9 level level NN cord-010092-uftc8inx 5962 10 in in IN cord-010092-uftc8inx 5962 11 RCCs rccs NN cord-010092-uftc8inx 5962 12 enables enable VBZ cord-010092-uftc8inx 5962 13 a a DT cord-010092-uftc8inx 5962 14 better well JJR cord-010092-uftc8inx 5962 15 storage storage NN cord-010092-uftc8inx 5962 16 of of IN cord-010092-uftc8inx 5962 17 RCC RCC NNP cord-010092-uftc8inx 5962 18 when when WRB cord-010092-uftc8inx 5962 19 a a DT cord-010092-uftc8inx 5962 20 late late JJ cord-010092-uftc8inx 5962 21 irradiation irradiation NN cord-010092-uftc8inx 5962 22 is be VBZ cord-010092-uftc8inx 5962 23 applied apply VBN cord-010092-uftc8inx 5962 24 . . . cord-010092-uftc8inx 5963 1 Background background NN cord-010092-uftc8inx 5963 2 : : : cord-010092-uftc8inx 5964 1 In in IN cord-010092-uftc8inx 5964 2 vitro vitro FW cord-010092-uftc8inx 5964 3 blood blood NNP cord-010092-uftc8inx 5964 4 circuit circuit NN cord-010092-uftc8inx 5964 5 machines machine NNS cord-010092-uftc8inx 5964 6 require require VBP cord-010092-uftc8inx 5964 7 a a DT cord-010092-uftc8inx 5964 8 constant constant JJ cord-010092-uftc8inx 5964 9 monitoring monitoring NN cord-010092-uftc8inx 5964 10 of of IN cord-010092-uftc8inx 5964 11 blood blood NN cord-010092-uftc8inx 5964 12 flow flow NN cord-010092-uftc8inx 5964 13 rate rate NN cord-010092-uftc8inx 5964 14 which which WDT cord-010092-uftc8inx 5964 15 have have VBP cord-010092-uftc8inx 5964 16 to to TO cord-010092-uftc8inx 5964 17 be be VB cord-010092-uftc8inx 5964 18 maintained maintain VBN cord-010092-uftc8inx 5964 19 at at IN cord-010092-uftc8inx 5964 20 a a DT cord-010092-uftc8inx 5964 21 constant constant JJ cord-010092-uftc8inx 5964 22 value value NN cord-010092-uftc8inx 5964 23 . . . cord-010092-uftc8inx 5965 1 Also also RB cord-010092-uftc8inx 5965 2 , , , cord-010092-uftc8inx 5965 3 measuring measure VBG cord-010092-uftc8inx 5965 4 the the DT cord-010092-uftc8inx 5965 5 hematocrit hematocrit NN cord-010092-uftc8inx 5965 6 of of IN cord-010092-uftc8inx 5965 7 flowing flow VBG cord-010092-uftc8inx 5965 8 blood blood NN cord-010092-uftc8inx 5965 9 in in IN cord-010092-uftc8inx 5965 10 such such JJ cord-010092-uftc8inx 5965 11 machines machine NNS cord-010092-uftc8inx 5965 12 is be VBZ cord-010092-uftc8inx 5965 13 essential essential JJ cord-010092-uftc8inx 5965 14 for for IN cord-010092-uftc8inx 5965 15 performing perform VBG cord-010092-uftc8inx 5965 16 real real JJ cord-010092-uftc8inx 5965 17 - - HYPH cord-010092-uftc8inx 5965 18 time time NN cord-010092-uftc8inx 5965 19 diagnostics diagnostic NNS cord-010092-uftc8inx 5965 20 . . . cord-010092-uftc8inx 5966 1 Recently recently RB cord-010092-uftc8inx 5966 2 , , , cord-010092-uftc8inx 5966 3 acoustophoresis acoustophoresis NNP cord-010092-uftc8inx 5966 4 has have VBZ cord-010092-uftc8inx 5966 5 emerged emerge VBN cord-010092-uftc8inx 5966 6 has have VBZ cord-010092-uftc8inx 5966 7 a a DT cord-010092-uftc8inx 5966 8 promising promising JJ cord-010092-uftc8inx 5966 9 blood blood NN cord-010092-uftc8inx 5966 10 separation separation NN cord-010092-uftc8inx 5966 11 technology technology NN cord-010092-uftc8inx 5966 12 capable capable JJ cord-010092-uftc8inx 5966 13 of of IN cord-010092-uftc8inx 5966 14 replacing replace VBG cord-010092-uftc8inx 5966 15 centrifugation centrifugation NN cord-010092-uftc8inx 5966 16 for for IN cord-010092-uftc8inx 5966 17 the the DT cord-010092-uftc8inx 5966 18 preparation preparation NN cord-010092-uftc8inx 5966 19 of of IN cord-010092-uftc8inx 5966 20 platelet platelet NN cord-010092-uftc8inx 5966 21 concentrate concentrate NN cord-010092-uftc8inx 5966 22 . . . cord-010092-uftc8inx 5967 1 To to TO cord-010092-uftc8inx 5967 2 avoid avoid VB cord-010092-uftc8inx 5967 3 damaging damaging JJ cord-010092-uftc8inx 5967 4 blood blood NN cord-010092-uftc8inx 5967 5 cells cell NNS cord-010092-uftc8inx 5967 6 , , , cord-010092-uftc8inx 5967 7 the the DT cord-010092-uftc8inx 5967 8 technique technique NN cord-010092-uftc8inx 5967 9 is be VBZ cord-010092-uftc8inx 5967 10 used use VBN cord-010092-uftc8inx 5967 11 without without IN cord-010092-uftc8inx 5967 12 infusing infuse VBG cord-010092-uftc8inx 5967 13 pumps pump NNS cord-010092-uftc8inx 5967 14 thus thus RB cord-010092-uftc8inx 5967 15 increasing increase VBG cord-010092-uftc8inx 5967 16 the the DT cord-010092-uftc8inx 5967 17 need need NN cord-010092-uftc8inx 5967 18 of of IN cord-010092-uftc8inx 5967 19 flow flow NN cord-010092-uftc8inx 5967 20 monitoring monitoring NN cord-010092-uftc8inx 5967 21 . . . cord-010092-uftc8inx 5968 1 However however RB cord-010092-uftc8inx 5968 2 , , , cord-010092-uftc8inx 5968 3 acoustophoresis acoustophoresis NN cord-010092-uftc8inx 5968 4 chips chip NNS cord-010092-uftc8inx 5968 5 performs perform VBZ cord-010092-uftc8inx 5968 6 at at IN cord-010092-uftc8inx 5968 7 low low JJ cord-010092-uftc8inx 5968 8 flow flow NN cord-010092-uftc8inx 5968 9 rates rate NNS cord-010092-uftc8inx 5968 10 , , , cord-010092-uftc8inx 5968 11 outside outside IN cord-010092-uftc8inx 5968 12 the the DT cord-010092-uftc8inx 5968 13 range range NN cord-010092-uftc8inx 5968 14 of of IN cord-010092-uftc8inx 5968 15 available available JJ cord-010092-uftc8inx 5968 16 commercial commercial JJ cord-010092-uftc8inx 5968 17 flow flow NN cord-010092-uftc8inx 5968 18 meters meter NNS cord-010092-uftc8inx 5968 19 . . . cord-010092-uftc8inx 5969 1 In in IN cord-010092-uftc8inx 5969 2 addition addition NN cord-010092-uftc8inx 5969 3 , , , cord-010092-uftc8inx 5969 4 hematocrit hematocrit NN cord-010092-uftc8inx 5969 5 measurement measurement NN cord-010092-uftc8inx 5969 6 is be VBZ cord-010092-uftc8inx 5969 7 of of IN cord-010092-uftc8inx 5969 8 a a DT cord-010092-uftc8inx 5969 9 particular particular JJ cord-010092-uftc8inx 5969 10 interest interest NN cord-010092-uftc8inx 5969 11 for for IN cord-010092-uftc8inx 5969 12 acoustophoresis acoustophoresis NN cord-010092-uftc8inx 5969 13 since since IN cord-010092-uftc8inx 5969 14 it -PRON- PRP cord-010092-uftc8inx 5969 15 is be VBZ cord-010092-uftc8inx 5969 16 a a DT cord-010092-uftc8inx 5969 17 direct direct JJ cord-010092-uftc8inx 5969 18 indicator indicator NN cord-010092-uftc8inx 5969 19 of of IN cord-010092-uftc8inx 5969 20 the the DT cord-010092-uftc8inx 5969 21 separation separation NN cord-010092-uftc8inx 5969 22 efficiency efficiency NN cord-010092-uftc8inx 5969 23 . . . cord-010092-uftc8inx 5970 1 Aims aim VBZ cord-010092-uftc8inx 5970 2 : : : cord-010092-uftc8inx 5971 1 In in IN cord-010092-uftc8inx 5971 2 this this DT cord-010092-uftc8inx 5971 3 study study NN cord-010092-uftc8inx 5971 4 , , , cord-010092-uftc8inx 5971 5 we -PRON- PRP cord-010092-uftc8inx 5971 6 present present VBP cord-010092-uftc8inx 5971 7 a a DT cord-010092-uftc8inx 5971 8 straightforward straightforward JJ cord-010092-uftc8inx 5971 9 Doppler Doppler NNP cord-010092-uftc8inx 5971 10 ultrasound ultrasound NN cord-010092-uftc8inx 5971 11 system system NN cord-010092-uftc8inx 5971 12 designed design VBN cord-010092-uftc8inx 5971 13 for for IN cord-010092-uftc8inx 5971 14 measuring measure VBG cord-010092-uftc8inx 5971 15 blood blood NN cord-010092-uftc8inx 5971 16 flow flow NN cord-010092-uftc8inx 5971 17 rate rate NN cord-010092-uftc8inx 5971 18 and and CC cord-010092-uftc8inx 5971 19 hematocrit hematocrit NN cord-010092-uftc8inx 5971 20 in in IN cord-010092-uftc8inx 5971 21 an an DT cord-010092-uftc8inx 5971 22 acoustophoresis acoustophoresis NN cord-010092-uftc8inx 5971 23 chip chip NN cord-010092-uftc8inx 5971 24 [ [ -LRB- cord-010092-uftc8inx 5971 25 Bohec Bohec NNP cord-010092-uftc8inx 5971 26 et et NNP cord-010092-uftc8inx 5971 27 al al NNP cord-010092-uftc8inx 5971 28 , , , cord-010092-uftc8inx 5971 29 Platelets platelet NNS cord-010092-uftc8inx 5971 30 , , , cord-010092-uftc8inx 5971 31 2017 2017 CD cord-010092-uftc8inx 5971 32 ] ] -RRB- cord-010092-uftc8inx 5971 33 . . . cord-010092-uftc8inx 5972 1 We -PRON- PRP cord-010092-uftc8inx 5972 2 show show VBP cord-010092-uftc8inx 5972 3 that that IN cord-010092-uftc8inx 5972 4 the the DT cord-010092-uftc8inx 5972 5 stability stability NN cord-010092-uftc8inx 5972 6 of of IN cord-010092-uftc8inx 5972 7 the the DT cord-010092-uftc8inx 5972 8 in in FW cord-010092-uftc8inx 5972 9 vitro vitro FW cord-010092-uftc8inx 5972 10 environment environment NN cord-010092-uftc8inx 5972 11 can can MD cord-010092-uftc8inx 5972 12 be be VB cord-010092-uftc8inx 5972 13 used use VBN cord-010092-uftc8inx 5972 14 to to TO cord-010092-uftc8inx 5972 15 obtain obtain VB cord-010092-uftc8inx 5972 16 high high JJ cord-010092-uftc8inx 5972 17 level level NN cord-010092-uftc8inx 5972 18 of of IN cord-010092-uftc8inx 5972 19 accuracy accuracy NN cord-010092-uftc8inx 5972 20 of of IN cord-010092-uftc8inx 5972 21 the the DT cord-010092-uftc8inx 5972 22 Doppler Doppler NNP cord-010092-uftc8inx 5972 23 method method NN cord-010092-uftc8inx 5972 24 using use VBG cord-010092-uftc8inx 5972 25 a a DT cord-010092-uftc8inx 5972 26 basic basic JJ cord-010092-uftc8inx 5972 27 and and CC cord-010092-uftc8inx 5972 28 low low JJ cord-010092-uftc8inx 5972 29 - - HYPH cord-010092-uftc8inx 5972 30 cost cost NN cord-010092-uftc8inx 5972 31 experimental experimental JJ cord-010092-uftc8inx 5972 32 set set NN cord-010092-uftc8inx 5972 33 - - HYPH cord-010092-uftc8inx 5972 34 up up NN cord-010092-uftc8inx 5972 35 . . . cord-010092-uftc8inx 5973 1 This this DT cord-010092-uftc8inx 5973 2 improvement improvement NN cord-010092-uftc8inx 5973 3 allows allow VBZ cord-010092-uftc8inx 5973 4 a a DT cord-010092-uftc8inx 5973 5 precise precise JJ cord-010092-uftc8inx 5973 6 measurement measurement NN cord-010092-uftc8inx 5973 7 of of IN cord-010092-uftc8inx 5973 8 flow flow NN cord-010092-uftc8inx 5973 9 rates rate NNS cord-010092-uftc8inx 5973 10 as as RB cord-010092-uftc8inx 5973 11 low low JJ cord-010092-uftc8inx 5973 12 as as IN cord-010092-uftc8inx 5973 13 0.5 0.5 CD cord-010092-uftc8inx 5973 14 ml ml NNS cord-010092-uftc8inx 5973 15 / / SYM cord-010092-uftc8inx 5973 16 min min NN cord-010092-uftc8inx 5973 17 in in IN cord-010092-uftc8inx 5973 18 sub sub JJ cord-010092-uftc8inx 5973 19 - - JJ cord-010092-uftc8inx 5973 20 millimeter millimeter JJ cord-010092-uftc8inx 5973 21 tubing tubing NN cord-010092-uftc8inx 5973 22 . . . cord-010092-uftc8inx 5974 1 Furthermore furthermore RB cord-010092-uftc8inx 5974 2 we -PRON- PRP cord-010092-uftc8inx 5974 3 evaluate evaluate VBP cord-010092-uftc8inx 5974 4 the the DT cord-010092-uftc8inx 5974 5 capability capability NN cord-010092-uftc8inx 5974 6 of of IN cord-010092-uftc8inx 5974 7 the the DT cord-010092-uftc8inx 5974 8 system system NN cord-010092-uftc8inx 5974 9 to to TO cord-010092-uftc8inx 5974 10 measure measure VB cord-010092-uftc8inx 5974 11 hematocrit hematocrit NN cord-010092-uftc8inx 5974 12 of of IN cord-010092-uftc8inx 5974 13 human human JJ cord-010092-uftc8inx 5974 14 blood blood NN cord-010092-uftc8inx 5974 15 samples sample NNS cord-010092-uftc8inx 5974 16 coming come VBG cord-010092-uftc8inx 5974 17 from from IN cord-010092-uftc8inx 5974 18 different different JJ cord-010092-uftc8inx 5974 19 donors donor NNS cord-010092-uftc8inx 5974 20 . . . cord-010092-uftc8inx 5975 1 Methods method NNS cord-010092-uftc8inx 5975 2 : : : cord-010092-uftc8inx 5976 1 The the DT cord-010092-uftc8inx 5976 2 experimental experimental JJ cord-010092-uftc8inx 5976 3 set set NN cord-010092-uftc8inx 5976 4 - - HYPH cord-010092-uftc8inx 5976 5 up up NN cord-010092-uftc8inx 5976 6 was be VBD cord-010092-uftc8inx 5976 7 constituted constitute VBN cord-010092-uftc8inx 5976 8 of of IN cord-010092-uftc8inx 5976 9 an an DT cord-010092-uftc8inx 5976 10 ultrasonic ultrasonic JJ cord-010092-uftc8inx 5976 11 Continuous Continuous NNP cord-010092-uftc8inx 5976 12 Wave Wave NNP cord-010092-uftc8inx 5976 13 Doppler Doppler NNP cord-010092-uftc8inx 5976 14 probe probe NN cord-010092-uftc8inx 5976 15 mounted mount VBD cord-010092-uftc8inx 5976 16 on on IN cord-010092-uftc8inx 5976 17 a a DT cord-010092-uftc8inx 5976 18 3D 3d JJ cord-010092-uftc8inx 5976 19 printed print VBN cord-010092-uftc8inx 5976 20 support support NN cord-010092-uftc8inx 5976 21 . . . cord-010092-uftc8inx 5977 1 The the DT cord-010092-uftc8inx 5977 2 accuracy accuracy NN cord-010092-uftc8inx 5977 3 of of IN cord-010092-uftc8inx 5977 4 flow flow NN cord-010092-uftc8inx 5977 5 rate rate NN cord-010092-uftc8inx 5977 6 measurements measurement NNS cord-010092-uftc8inx 5977 7 between between IN cord-010092-uftc8inx 5977 8 0.5 0.5 CD cord-010092-uftc8inx 5977 9 ml ml NNS cord-010092-uftc8inx 5977 10 / / SYM cord-010092-uftc8inx 5977 11 min min NN cord-010092-uftc8inx 5977 12 and and CC cord-010092-uftc8inx 5977 13 1.5 1.5 CD cord-010092-uftc8inx 5977 14 ml ml NNS cord-010092-uftc8inx 5977 15 / / SYM cord-010092-uftc8inx 5977 16 min min NNP cord-010092-uftc8inx 5977 17 was be VBD cord-010092-uftc8inx 5977 18 evaluated evaluate VBN cord-010092-uftc8inx 5977 19 as as RB cord-010092-uftc8inx 5977 20 well well RB cord-010092-uftc8inx 5977 21 as as IN cord-010092-uftc8inx 5977 22 the the DT cord-010092-uftc8inx 5977 23 optimal optimal JJ cord-010092-uftc8inx 5977 24 measurement measurement NN cord-010092-uftc8inx 5977 25 time time NN cord-010092-uftc8inx 5977 26 . . . cord-010092-uftc8inx 5978 1 For for IN cord-010092-uftc8inx 5978 2 4 4 CD cord-010092-uftc8inx 5978 3 different different JJ cord-010092-uftc8inx 5978 4 blood blood NN cord-010092-uftc8inx 5978 5 bags bag NNS cord-010092-uftc8inx 5978 6 , , , cord-010092-uftc8inx 5978 7 the the DT cord-010092-uftc8inx 5978 8 relationship relationship NN cord-010092-uftc8inx 5978 9 linking link VBG cord-010092-uftc8inx 5978 10 the the DT cord-010092-uftc8inx 5978 11 total total JJ cord-010092-uftc8inx 5978 12 energy energy NN cord-010092-uftc8inx 5978 13 of of IN cord-010092-uftc8inx 5978 14 Doppler Doppler NNP cord-010092-uftc8inx 5978 15 signals signal NNS cord-010092-uftc8inx 5978 16 and and CC cord-010092-uftc8inx 5978 17 hematocrit hematocrit NN cord-010092-uftc8inx 5978 18 was be VBD cord-010092-uftc8inx 5978 19 derived derive VBN cord-010092-uftc8inx 5978 20 . . . cord-010092-uftc8inx 5979 1 Hematocrit hematocrit NN cord-010092-uftc8inx 5979 2 in in IN cord-010092-uftc8inx 5979 3 a a DT cord-010092-uftc8inx 5979 4 range range NN cord-010092-uftc8inx 5979 5 under under IN cord-010092-uftc8inx 5979 6 8 8 CD cord-010092-uftc8inx 5979 7 % % NN cord-010092-uftc8inx 5979 8 was be VBD cord-010092-uftc8inx 5979 9 estimated estimate VBN cord-010092-uftc8inx 5979 10 from from IN cord-010092-uftc8inx 5979 11 Doppler Doppler NNP cord-010092-uftc8inx 5979 12 signals signal NNS cord-010092-uftc8inx 5979 13 for for IN cord-010092-uftc8inx 5979 14 each each DT cord-010092-uftc8inx 5979 15 blood blood NN cord-010092-uftc8inx 5979 16 bag bag NN cord-010092-uftc8inx 5979 17 . . . cord-010092-uftc8inx 5980 1 Results result NNS cord-010092-uftc8inx 5980 2 : : : cord-010092-uftc8inx 5981 1 The the DT cord-010092-uftc8inx 5981 2 system system NN cord-010092-uftc8inx 5981 3 is be VBZ cord-010092-uftc8inx 5981 4 able able JJ cord-010092-uftc8inx 5981 5 to to TO cord-010092-uftc8inx 5981 6 acquire acquire VB cord-010092-uftc8inx 5981 7 exploitable exploitable JJ cord-010092-uftc8inx 5981 8 Doppler Doppler NNP cord-010092-uftc8inx 5981 9 signals signal NNS cord-010092-uftc8inx 5981 10 for for IN cord-010092-uftc8inx 5981 11 the the DT cord-010092-uftc8inx 5981 12 whole whole JJ cord-010092-uftc8inx 5981 13 flow flow NN cord-010092-uftc8inx 5981 14 rate rate NN cord-010092-uftc8inx 5981 15 and and CC cord-010092-uftc8inx 5981 16 hematocrit hematocrit NN cord-010092-uftc8inx 5981 17 range range NN cord-010092-uftc8inx 5981 18 . . . cord-010092-uftc8inx 5982 1 Flow flow NN cord-010092-uftc8inx 5982 2 rate rate NN cord-010092-uftc8inx 5982 3 estimation estimation NN cord-010092-uftc8inx 5982 4 from from IN cord-010092-uftc8inx 5982 5 the the DT cord-010092-uftc8inx 5982 6 signals signal NNS cord-010092-uftc8inx 5982 7 shows show VBZ cord-010092-uftc8inx 5982 8 a a DT cord-010092-uftc8inx 5982 9 high high JJ cord-010092-uftc8inx 5982 10 accuracy accuracy NN cord-010092-uftc8inx 5982 11 with with IN cord-010092-uftc8inx 5982 12 a a DT cord-010092-uftc8inx 5982 13 mean mean JJ cord-010092-uftc8inx 5982 14 measurement measurement NN cord-010092-uftc8inx 5982 15 error error NN cord-010092-uftc8inx 5982 16 under under IN cord-010092-uftc8inx 5982 17 3 3 CD cord-010092-uftc8inx 5982 18 % % NN cord-010092-uftc8inx 5982 19 for for IN cord-010092-uftc8inx 5982 20 a a DT cord-010092-uftc8inx 5982 21 measurement measurement JJ cord-010092-uftc8inx 5982 22 time time NN cord-010092-uftc8inx 5982 23 of of IN cord-010092-uftc8inx 5982 24 2s 2s CD cord-010092-uftc8inx 5982 25 . . . cord-010092-uftc8inx 5983 1 The the DT cord-010092-uftc8inx 5983 2 mean mean JJ cord-010092-uftc8inx 5983 3 error error NN cord-010092-uftc8inx 5983 4 is be VBZ cord-010092-uftc8inx 5983 5 still still RB cord-010092-uftc8inx 5983 6 under under IN cord-010092-uftc8inx 5983 7 5 5 CD cord-010092-uftc8inx 5983 8 % % NN cord-010092-uftc8inx 5983 9 for for IN cord-010092-uftc8inx 5983 10 a a DT cord-010092-uftc8inx 5983 11 measurement measurement JJ cord-010092-uftc8inx 5983 12 time time NN cord-010092-uftc8inx 5983 13 of of IN cord-010092-uftc8inx 5983 14 0.5s 0.5s CD cord-010092-uftc8inx 5983 15 . . . cord-010092-uftc8inx 5984 1 Hematocrit hematocrit NN cord-010092-uftc8inx 5984 2 estimation estimation NN cord-010092-uftc8inx 5984 3 from from IN cord-010092-uftc8inx 5984 4 Doppler Doppler NNP cord-010092-uftc8inx 5984 5 signals signal NNS cord-010092-uftc8inx 5984 6 shows show VBZ cord-010092-uftc8inx 5984 7 a a DT cord-010092-uftc8inx 5984 8 good good JJ cord-010092-uftc8inx 5984 9 linear linear JJ cord-010092-uftc8inx 5984 10 correlation correlation NN cord-010092-uftc8inx 5984 11 with with IN cord-010092-uftc8inx 5984 12 reference reference NN cord-010092-uftc8inx 5984 13 measurements measurement NNS cord-010092-uftc8inx 5984 14 for for IN cord-010092-uftc8inx 5984 15 bags bag NNS cord-010092-uftc8inx 5984 16 2 2 CD cord-010092-uftc8inx 5984 17 , , , cord-010092-uftc8inx 5984 18 3 3 CD cord-010092-uftc8inx 5984 19 and and CC cord-010092-uftc8inx 5984 20 4 4 CD cord-010092-uftc8inx 5984 21 . . . cord-010092-uftc8inx 5985 1 Hematocrit hematocrit NN cord-010092-uftc8inx 5985 2 estimation estimation NN cord-010092-uftc8inx 5985 3 for for IN cord-010092-uftc8inx 5985 4 bag bag NN cord-010092-uftc8inx 5985 5 1 1 CD cord-010092-uftc8inx 5985 6 diverges diverge VBZ cord-010092-uftc8inx 5985 7 from from IN cord-010092-uftc8inx 5985 8 reference reference NN cord-010092-uftc8inx 5985 9 for for IN cord-010092-uftc8inx 5985 10 values value NNS cord-010092-uftc8inx 5985 11 above above IN cord-010092-uftc8inx 5985 12 6 6 CD cord-010092-uftc8inx 5985 13 % % NN cord-010092-uftc8inx 5985 14 . . . cord-010092-uftc8inx 5986 1 Summary Summary NNP cord-010092-uftc8inx 5986 2 / / SYM cord-010092-uftc8inx 5986 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 5986 4 : : : cord-010092-uftc8inx 5987 1 The the DT cord-010092-uftc8inx 5987 2 proposed propose VBN cord-010092-uftc8inx 5987 3 Doppler doppler NN cord-010092-uftc8inx 5987 4 ultrasound ultrasound NN cord-010092-uftc8inx 5987 5 system system NN cord-010092-uftc8inx 5987 6 is be VBZ cord-010092-uftc8inx 5987 7 capable capable JJ cord-010092-uftc8inx 5987 8 of of IN cord-010092-uftc8inx 5987 9 measuring measure VBG cord-010092-uftc8inx 5987 10 low low JJ cord-010092-uftc8inx 5987 11 blood blood NN cord-010092-uftc8inx 5987 12 flow flow NN cord-010092-uftc8inx 5987 13 rate rate NN cord-010092-uftc8inx 5987 14 in in IN cord-010092-uftc8inx 5987 15 narrow narrow JJ cord-010092-uftc8inx 5987 16 medical medical JJ cord-010092-uftc8inx 5987 17 tubing tubing NN cord-010092-uftc8inx 5987 18 with with IN cord-010092-uftc8inx 5987 19 a a DT cord-010092-uftc8inx 5987 20 high high JJ cord-010092-uftc8inx 5987 21 accuracy accuracy NN cord-010092-uftc8inx 5987 22 . . . cord-010092-uftc8inx 5988 1 It -PRON- PRP cord-010092-uftc8inx 5988 2 is be VBZ cord-010092-uftc8inx 5988 3 particularly particularly RB cord-010092-uftc8inx 5988 4 suited suited JJ cord-010092-uftc8inx 5988 5 for for IN cord-010092-uftc8inx 5988 6 an an DT cord-010092-uftc8inx 5988 7 acoustophoresis acoustophoresis NN cord-010092-uftc8inx 5988 8 device device NN cord-010092-uftc8inx 5988 9 but but CC cord-010092-uftc8inx 5988 10 the the DT cord-010092-uftc8inx 5988 11 versatility versatility NN cord-010092-uftc8inx 5988 12 of of IN cord-010092-uftc8inx 5988 13 the the DT cord-010092-uftc8inx 5988 14 system system NN cord-010092-uftc8inx 5988 15 makes make VBZ cord-010092-uftc8inx 5988 16 it -PRON- PRP cord-010092-uftc8inx 5988 17 easily easily RB cord-010092-uftc8inx 5988 18 applicable applicable JJ cord-010092-uftc8inx 5988 19 to to IN cord-010092-uftc8inx 5988 20 any any DT cord-010092-uftc8inx 5988 21 in in FW cord-010092-uftc8inx 5988 22 vitro vitro FW cord-010092-uftc8inx 5988 23 blood blood NN cord-010092-uftc8inx 5988 24 circuit circuit NN cord-010092-uftc8inx 5988 25 . . . cord-010092-uftc8inx 5989 1 We -PRON- PRP cord-010092-uftc8inx 5989 2 furthermore furthermore RB cord-010092-uftc8inx 5989 3 demonstrated demonstrate VBD cord-010092-uftc8inx 5989 4 that that IN cord-010092-uftc8inx 5989 5 the the DT cord-010092-uftc8inx 5989 6 system system NN cord-010092-uftc8inx 5989 7 can can MD cord-010092-uftc8inx 5989 8 be be VB cord-010092-uftc8inx 5989 9 used use VBN cord-010092-uftc8inx 5989 10 for for IN cord-010092-uftc8inx 5989 11 measuring measure VBG cord-010092-uftc8inx 5989 12 hematocrit hematocrit NN cord-010092-uftc8inx 5989 13 under under IN cord-010092-uftc8inx 5989 14 8 8 CD cord-010092-uftc8inx 5989 15 % % NN cord-010092-uftc8inx 5989 16 without without IN cord-010092-uftc8inx 5989 17 additional additional JJ cord-010092-uftc8inx 5989 18 developments development NNS cord-010092-uftc8inx 5989 19 . . . cord-010092-uftc8inx 5990 1 This this DT cord-010092-uftc8inx 5990 2 finds find VBZ cord-010092-uftc8inx 5990 3 interesting interesting JJ cord-010092-uftc8inx 5990 4 applications application NNS cord-010092-uftc8inx 5990 5 in in IN cord-010092-uftc8inx 5990 6 blood blood NN cord-010092-uftc8inx 5990 7 sorting sorting NN cord-010092-uftc8inx 5990 8 technologies technology NNS cord-010092-uftc8inx 5990 9 but but CC cord-010092-uftc8inx 5990 10 also also RB cord-010092-uftc8inx 5990 11 demonstrates demonstrate VBZ cord-010092-uftc8inx 5990 12 that that IN cord-010092-uftc8inx 5990 13 Doppler Doppler NNP cord-010092-uftc8inx 5990 14 ultrasound ultrasound NN cord-010092-uftc8inx 5990 15 is be VBZ cord-010092-uftc8inx 5990 16 a a DT cord-010092-uftc8inx 5990 17 potential potential JJ cord-010092-uftc8inx 5990 18 simple simple JJ cord-010092-uftc8inx 5990 19 and and CC cord-010092-uftc8inx 5990 20 low low JJ cord-010092-uftc8inx 5990 21 cost cost NN cord-010092-uftc8inx 5990 22 method method NN cord-010092-uftc8inx 5990 23 for for IN cord-010092-uftc8inx 5990 24 measuring measure VBG cord-010092-uftc8inx 5990 25 hematocrit hematocrit NN cord-010092-uftc8inx 5990 26 of of IN cord-010092-uftc8inx 5990 27 flowing flow VBG cord-010092-uftc8inx 5990 28 blood blood NN cord-010092-uftc8inx 5990 29 in in IN cord-010092-uftc8inx 5990 30 vitro vitro FW cord-010092-uftc8inx 5990 31 . . . cord-010092-uftc8inx 5991 1 Background background NN cord-010092-uftc8inx 5991 2 : : : cord-010092-uftc8inx 5992 1 Hereditary hereditary JJ cord-010092-uftc8inx 5992 2 hemochromatosis hemochromatosis NN cord-010092-uftc8inx 5992 3 ( ( -LRB- cord-010092-uftc8inx 5992 4 HH HH NNP cord-010092-uftc8inx 5992 5 ) ) -RRB- cord-010092-uftc8inx 5992 6 is be VBZ cord-010092-uftc8inx 5992 7 the the DT cord-010092-uftc8inx 5992 8 most most RBS cord-010092-uftc8inx 5992 9 common common JJ cord-010092-uftc8inx 5992 10 genetic genetic JJ cord-010092-uftc8inx 5992 11 disorder disorder NN cord-010092-uftc8inx 5992 12 in in IN cord-010092-uftc8inx 5992 13 populations population NNS cord-010092-uftc8inx 5992 14 of of IN cord-010092-uftc8inx 5992 15 Northern northern JJ cord-010092-uftc8inx 5992 16 European european JJ cord-010092-uftc8inx 5992 17 descent descent NN cord-010092-uftc8inx 5992 18 manifesting manifest VBG cord-010092-uftc8inx 5992 19 with with IN cord-010092-uftc8inx 5992 20 high high JJ cord-010092-uftc8inx 5992 21 levels level NNS cord-010092-uftc8inx 5992 22 of of IN cord-010092-uftc8inx 5992 23 storage storage NN cord-010092-uftc8inx 5992 24 iron iron NN cord-010092-uftc8inx 5992 25 ( ( -LRB- cord-010092-uftc8inx 5992 26 ferritin ferritin NN cord-010092-uftc8inx 5992 27 ) ) -RRB- cord-010092-uftc8inx 5992 28 in in IN cord-010092-uftc8inx 5992 29 blood blood NN cord-010092-uftc8inx 5992 30 and and CC cord-010092-uftc8inx 5992 31 tissues tissue NNS cord-010092-uftc8inx 5992 32 . . . cord-010092-uftc8inx 5993 1 The the DT cord-010092-uftc8inx 5993 2 standard standard JJ cord-010092-uftc8inx 5993 3 treatment treatment NN cord-010092-uftc8inx 5993 4 is be VBZ cord-010092-uftc8inx 5993 5 serial serial JJ cord-010092-uftc8inx 5993 6 therapeutic therapeutic JJ cord-010092-uftc8inx 5993 7 phlebotomy phlebotomy NN cord-010092-uftc8inx 5993 8 to to TO cord-010092-uftc8inx 5993 9 decrease decrease VB cord-010092-uftc8inx 5993 10 iron iron NN cord-010092-uftc8inx 5993 11 overload overload NN cord-010092-uftc8inx 5993 12 . . . cord-010092-uftc8inx 5994 1 The the DT cord-010092-uftc8inx 5994 2 collected collect VBN cord-010092-uftc8inx 5994 3 blood blood NN cord-010092-uftc8inx 5994 4 is be VBZ cord-010092-uftc8inx 5994 5 frequently frequently RB cord-010092-uftc8inx 5994 6 discarded discard VBN cord-010092-uftc8inx 5994 7 but but CC cord-010092-uftc8inx 5994 8 some some DT cord-010092-uftc8inx 5994 9 blood blood NN cord-010092-uftc8inx 5994 10 banks bank NNS cord-010092-uftc8inx 5994 11 allow allow VBP cord-010092-uftc8inx 5994 12 " " `` cord-010092-uftc8inx 5994 13 healthy healthy JJ cord-010092-uftc8inx 5994 14 " " '' cord-010092-uftc8inx 5994 15 HH hh NN cord-010092-uftc8inx 5994 16 patients patient NNS cord-010092-uftc8inx 5994 17 to to TO cord-010092-uftc8inx 5994 18 donate donate VB cord-010092-uftc8inx 5994 19 blood blood NN cord-010092-uftc8inx 5994 20 for for IN cord-010092-uftc8inx 5994 21 patient patient JJ cord-010092-uftc8inx 5994 22 use use NN cord-010092-uftc8inx 5994 23 . . . cord-010092-uftc8inx 5995 1 Red red JJ cord-010092-uftc8inx 5995 2 cell cell NN cord-010092-uftc8inx 5995 3 concentrates concentrate VBZ cord-010092-uftc8inx 5995 4 from from IN cord-010092-uftc8inx 5995 5 HH HH NNP cord-010092-uftc8inx 5995 6 donors donor NNS cord-010092-uftc8inx 5995 7 have have VBP cord-010092-uftc8inx 5995 8 been be VBN cord-010092-uftc8inx 5995 9 reported report VBN cord-010092-uftc8inx 5995 10 safe safe JJ cord-010092-uftc8inx 5995 11 for for IN cord-010092-uftc8inx 5995 12 transfusion transfusion NN cord-010092-uftc8inx 5995 13 , , , cord-010092-uftc8inx 5995 14 but but CC cord-010092-uftc8inx 5995 15 little little JJ cord-010092-uftc8inx 5995 16 or or CC cord-010092-uftc8inx 5995 17 no no DT cord-010092-uftc8inx 5995 18 data data NN cord-010092-uftc8inx 5995 19 is be VBZ cord-010092-uftc8inx 5995 20 available available JJ cord-010092-uftc8inx 5995 21 on on IN cord-010092-uftc8inx 5995 22 platelet platelet NN cord-010092-uftc8inx 5995 23 concentrates concentrate VBZ cord-010092-uftc8inx 5995 24 from from IN cord-010092-uftc8inx 5995 25 HH HH NNP cord-010092-uftc8inx 5995 26 donors donor NNS cord-010092-uftc8inx 5995 27 , , , cord-010092-uftc8inx 5995 28 including include VBG cord-010092-uftc8inx 5995 29 the the DT cord-010092-uftc8inx 5995 30 potential potential JJ cord-010092-uftc8inx 5995 31 contribution contribution NN cord-010092-uftc8inx 5995 32 of of IN cord-010092-uftc8inx 5995 33 surplus surplus JJ cord-010092-uftc8inx 5995 34 iron iron NN cord-010092-uftc8inx 5995 35 to to IN cord-010092-uftc8inx 5995 36 the the DT cord-010092-uftc8inx 5995 37 " " `` cord-010092-uftc8inx 5995 38 platelet platelet NN cord-010092-uftc8inx 5995 39 storage storage NN cord-010092-uftc8inx 5995 40 lesion lesion NN cord-010092-uftc8inx 5995 41 " " '' cord-010092-uftc8inx 5995 42 . . . cord-010092-uftc8inx 5996 1 Aims aim VBZ cord-010092-uftc8inx 5996 2 : : : cord-010092-uftc8inx 5997 1 The the DT cord-010092-uftc8inx 5997 2 aim aim NN cord-010092-uftc8inx 5997 3 of of IN cord-010092-uftc8inx 5997 4 this this DT cord-010092-uftc8inx 5997 5 study study NN cord-010092-uftc8inx 5997 6 was be VBD cord-010092-uftc8inx 5997 7 to to TO cord-010092-uftc8inx 5997 8 compare compare VB cord-010092-uftc8inx 5997 9 platelet platelet NN cord-010092-uftc8inx 5997 10 quality quality NN cord-010092-uftc8inx 5997 11 , , , cord-010092-uftc8inx 5997 12 activation activation NN cord-010092-uftc8inx 5997 13 and and CC cord-010092-uftc8inx 5997 14 aggregation aggregation NN cord-010092-uftc8inx 5997 15 over over IN cord-010092-uftc8inx 5997 16 seven seven CD cord-010092-uftc8inx 5997 17 - - HYPH cord-010092-uftc8inx 5997 18 day day NN cord-010092-uftc8inx 5997 19 storage storage NN cord-010092-uftc8inx 5997 20 in in IN cord-010092-uftc8inx 5997 21 platelet platelet NN cord-010092-uftc8inx 5997 22 - - HYPH cord-010092-uftc8inx 5997 23 rich rich JJ cord-010092-uftc8inx 5997 24 plasma plasma NN cord-010092-uftc8inx 5997 25 from from IN cord-010092-uftc8inx 5997 26 patients patient NNS cord-010092-uftc8inx 5997 27 with with IN cord-010092-uftc8inx 5997 28 newly newly RB cord-010092-uftc8inx 5997 29 diagnosed diagnose VBN cord-010092-uftc8inx 5997 30 HH HH NNP cord-010092-uftc8inx 5997 31 and and CC cord-010092-uftc8inx 5997 32 from from IN cord-010092-uftc8inx 5997 33 healthy healthy JJ cord-010092-uftc8inx 5997 34 controls control NNS cord-010092-uftc8inx 5997 35 . . . cord-010092-uftc8inx 5998 1 Methods method NNS cord-010092-uftc8inx 5998 2 : : : cord-010092-uftc8inx 5998 3 Whole whole JJ cord-010092-uftc8inx 5998 4 blood blood NN cord-010092-uftc8inx 5998 5 ( ( -LRB- cord-010092-uftc8inx 5998 6 450 450 CD cord-010092-uftc8inx 5998 7 mL ml NN cord-010092-uftc8inx 5998 8 ) ) -RRB- cord-010092-uftc8inx 5998 9 was be VBD cord-010092-uftc8inx 5998 10 drawn draw VBN cord-010092-uftc8inx 5998 11 into into IN cord-010092-uftc8inx 5998 12 CompoFlow CompoFlow NNP cord-010092-uftc8inx 5998 13 blood blood NN cord-010092-uftc8inx 5998 14 bags bag NNS cord-010092-uftc8inx 5998 15 containing contain VBG cord-010092-uftc8inx 5998 16 CPD CPD NNP cord-010092-uftc8inx 5998 17 and and CC cord-010092-uftc8inx 5998 18 SAG SAG NNP cord-010092-uftc8inx 5998 19 - - HYPH cord-010092-uftc8inx 5998 20 M M NNP cord-010092-uftc8inx 5998 21 from from IN cord-010092-uftc8inx 5998 22 10 10 CD cord-010092-uftc8inx 5998 23 healthy healthy JJ cord-010092-uftc8inx 5998 24 controls control NNS cord-010092-uftc8inx 5998 25 and and CC cord-010092-uftc8inx 5998 26 10 10 CD cord-010092-uftc8inx 5998 27 newly newly RB cord-010092-uftc8inx 5998 28 diagnosed diagnose VBN cord-010092-uftc8inx 5998 29 HH HH NNP cord-010092-uftc8inx 5998 30 patients patient NNS cord-010092-uftc8inx 5998 31 . . . cord-010092-uftc8inx 5999 1 Platelet platelet NN cord-010092-uftc8inx 5999 2 - - HYPH cord-010092-uftc8inx 5999 3 rich rich JJ cord-010092-uftc8inx 5999 4 plasma plasma NN cord-010092-uftc8inx 5999 5 ( ( -LRB- cord-010092-uftc8inx 5999 6 PRP PRP NNP cord-010092-uftc8inx 5999 7 ) ) -RRB- cord-010092-uftc8inx 5999 8 was be VBD cord-010092-uftc8inx 5999 9 prepared prepare VBN cord-010092-uftc8inx 5999 10 from from IN cord-010092-uftc8inx 5999 11 whole whole JJ cord-010092-uftc8inx 5999 12 blood blood NN cord-010092-uftc8inx 5999 13 and and CC cord-010092-uftc8inx 5999 14 split split VBD cord-010092-uftc8inx 5999 15 into into IN cord-010092-uftc8inx 5999 16 four four CD cord-010092-uftc8inx 5999 17 Compo Compo NNP cord-010092-uftc8inx 5999 18 - - HYPH cord-010092-uftc8inx 5999 19 Flex Flex NNP cord-010092-uftc8inx 5999 20 bags bag NNS cord-010092-uftc8inx 5999 21 each each DT cord-010092-uftc8inx 5999 22 containing contain VBG cord-010092-uftc8inx 5999 23 20 20 CD cord-010092-uftc8inx 5999 24 mL ml NN cord-010092-uftc8inx 5999 25 PRP prp NN cord-010092-uftc8inx 5999 26 ( ( -LRB- cord-010092-uftc8inx 5999 27 range range VBP cord-010092-uftc8inx 5999 28 270 270 CD cord-010092-uftc8inx 5999 29 - - SYM cord-010092-uftc8inx 5999 30 320 320 CD cord-010092-uftc8inx 5999 31 9 9 CD cord-010092-uftc8inx 5999 32 10 10 CD cord-010092-uftc8inx 5999 33 9 9 CD cord-010092-uftc8inx 5999 34 platelets platelet NNS cord-010092-uftc8inx 5999 35 / / SYM cord-010092-uftc8inx 5999 36 L l NN cord-010092-uftc8inx 5999 37 ) ) -RRB- cord-010092-uftc8inx 5999 38 . . . cord-010092-uftc8inx 6000 1 Platelet platelet NN cord-010092-uftc8inx 6000 2 quality quality NN cord-010092-uftc8inx 6000 3 tests test NNS cord-010092-uftc8inx 6000 4 were be VBD cord-010092-uftc8inx 6000 5 performed perform VBN cord-010092-uftc8inx 6000 6 on on IN cord-010092-uftc8inx 6000 7 days day NNS cord-010092-uftc8inx 6000 8 0 0 CD cord-010092-uftc8inx 6000 9 , , , cord-010092-uftc8inx 6000 10 1 1 CD cord-010092-uftc8inx 6000 11 , , , cord-010092-uftc8inx 6000 12 3 3 CD cord-010092-uftc8inx 6000 13 , , , cord-010092-uftc8inx 6000 14 5 5 CD cord-010092-uftc8inx 6000 15 and and CC cord-010092-uftc8inx 6000 16 7 7 CD cord-010092-uftc8inx 6000 17 of of IN cord-010092-uftc8inx 6000 18 storage storage NN cord-010092-uftc8inx 6000 19 . . . cord-010092-uftc8inx 6001 1 Platelet platelet NN cord-010092-uftc8inx 6001 2 aggregation aggregation NN cord-010092-uftc8inx 6001 3 was be VBD cord-010092-uftc8inx 6001 4 tested test VBN cord-010092-uftc8inx 6001 5 using use VBG cord-010092-uftc8inx 6001 6 a a DT cord-010092-uftc8inx 6001 7 Chrono Chrono NNP cord-010092-uftc8inx 6001 8 - - HYPH cord-010092-uftc8inx 6001 9 Log Log NNP cord-010092-uftc8inx 6001 10 aggregometer aggregometer NN cord-010092-uftc8inx 6001 11 and and CC cord-010092-uftc8inx 6001 12 four four CD cord-010092-uftc8inx 6001 13 agonists agonist NNS cord-010092-uftc8inx 6001 14 ( ( -LRB- cord-010092-uftc8inx 6001 15 ADP ADP NNP cord-010092-uftc8inx 6001 16 , , , cord-010092-uftc8inx 6001 17 arachidonic arachidonic JJ cord-010092-uftc8inx 6001 18 acid acid NN cord-010092-uftc8inx 6001 19 , , , cord-010092-uftc8inx 6001 20 collagen collagen NN cord-010092-uftc8inx 6001 21 , , , cord-010092-uftc8inx 6001 22 and and CC cord-010092-uftc8inx 6001 23 epinephrine epinephrine NN cord-010092-uftc8inx 6001 24 ) ) -RRB- cord-010092-uftc8inx 6001 25 . . . cord-010092-uftc8inx 6002 1 Platelet platelet NN cord-010092-uftc8inx 6002 2 expression expression NN cord-010092-uftc8inx 6002 3 of of IN cord-010092-uftc8inx 6002 4 CD41 CD41 NNP cord-010092-uftc8inx 6002 5 , , , cord-010092-uftc8inx 6002 6 CD42b CD42b NNP cord-010092-uftc8inx 6002 7 , , , cord-010092-uftc8inx 6002 8 and and CC cord-010092-uftc8inx 6002 9 CD62P CD62P NNP cord-010092-uftc8inx 6002 10 was be VBD cord-010092-uftc8inx 6002 11 measured measure VBN cord-010092-uftc8inx 6002 12 with with IN cord-010092-uftc8inx 6002 13 flow flow NN cord-010092-uftc8inx 6002 14 cytometry cytometry NN cord-010092-uftc8inx 6002 15 while while IN cord-010092-uftc8inx 6002 16 pH ph NN cord-010092-uftc8inx 6002 17 and and CC cord-010092-uftc8inx 6002 18 metabolites metabolite NNS cord-010092-uftc8inx 6002 19 were be VBD cord-010092-uftc8inx 6002 20 measured measure VBN cord-010092-uftc8inx 6002 21 with with IN cord-010092-uftc8inx 6002 22 a a DT cord-010092-uftc8inx 6002 23 blood blood NN cord-010092-uftc8inx 6002 24 gas gas NN cord-010092-uftc8inx 6002 25 analyzer analyzer NN cord-010092-uftc8inx 6002 26 . . . cord-010092-uftc8inx 6003 1 sCD40L sCD40L NNP cord-010092-uftc8inx 6003 2 and and CC cord-010092-uftc8inx 6003 3 sCD62p scd62p NN cord-010092-uftc8inx 6003 4 in in IN cord-010092-uftc8inx 6003 5 the the DT cord-010092-uftc8inx 6003 6 supernatant supernatant NN cord-010092-uftc8inx 6003 7 were be VBD cord-010092-uftc8inx 6003 8 quantified quantify VBN cord-010092-uftc8inx 6003 9 using use VBG cord-010092-uftc8inx 6003 10 enzyme enzyme NN cord-010092-uftc8inx 6003 11 - - HYPH cord-010092-uftc8inx 6003 12 linked link VBN cord-010092-uftc8inx 6003 13 immunosorbent immunosorbent JJ cord-010092-uftc8inx 6003 14 assays assay NNS cord-010092-uftc8inx 6003 15 . . . cord-010092-uftc8inx 6004 1 Results result NNS cord-010092-uftc8inx 6004 2 : : : cord-010092-uftc8inx 6005 1 Both both DT cord-010092-uftc8inx 6005 2 HH hh NN cord-010092-uftc8inx 6005 3 and and CC cord-010092-uftc8inx 6005 4 control control NN cord-010092-uftc8inx 6005 5 groups group NNS cord-010092-uftc8inx 6005 6 included include VBD cord-010092-uftc8inx 6005 7 7 7 CD cord-010092-uftc8inx 6005 8 males male NNS cord-010092-uftc8inx 6005 9 and and CC cord-010092-uftc8inx 6005 10 3 3 CD cord-010092-uftc8inx 6005 11 females female NNS cord-010092-uftc8inx 6005 12 . . . cord-010092-uftc8inx 6006 1 The the DT cord-010092-uftc8inx 6006 2 mean mean JJ cord-010092-uftc8inx 6006 3 age age NN cord-010092-uftc8inx 6006 4 was be VBD cord-010092-uftc8inx 6006 5 significantly significantly RB cord-010092-uftc8inx 6006 6 lower low JJR cord-010092-uftc8inx 6006 7 in in IN cord-010092-uftc8inx 6006 8 the the DT cord-010092-uftc8inx 6006 9 control control NN cord-010092-uftc8inx 6006 10 group group NN cord-010092-uftc8inx 6006 11 , , , cord-010092-uftc8inx 6006 12 35 35 CD cord-010092-uftc8inx 6006 13 years year NNS cord-010092-uftc8inx 6006 14 ( ( -LRB- cord-010092-uftc8inx 6006 15 22 22 CD cord-010092-uftc8inx 6006 16 - - SYM cord-010092-uftc8inx 6006 17 55 55 CD cord-010092-uftc8inx 6006 18 years year NNS cord-010092-uftc8inx 6006 19 ) ) -RRB- cord-010092-uftc8inx 6006 20 , , , cord-010092-uftc8inx 6006 21 than than IN cord-010092-uftc8inx 6006 22 in in IN cord-010092-uftc8inx 6006 23 the the DT cord-010092-uftc8inx 6006 24 HH HH NNP cord-010092-uftc8inx 6006 25 group group NN cord-010092-uftc8inx 6006 26 , , , cord-010092-uftc8inx 6006 27 55.7 55.7 CD cord-010092-uftc8inx 6006 28 years year NNS cord-010092-uftc8inx 6006 29 ( ( -LRB- cord-010092-uftc8inx 6006 30 29 29 CD cord-010092-uftc8inx 6006 31 - - SYM cord-010092-uftc8inx 6006 32 77 77 CD cord-010092-uftc8inx 6006 33 years year NNS cord-010092-uftc8inx 6006 34 ) ) -RRB- cord-010092-uftc8inx 6007 1 ( ( -LRB- cord-010092-uftc8inx 6007 2 P p NN cord-010092-uftc8inx 6007 3 = = SYM cord-010092-uftc8inx 6007 4 0.004 0.004 CD cord-010092-uftc8inx 6007 5 ) ) -RRB- cord-010092-uftc8inx 6007 6 while while IN cord-010092-uftc8inx 6007 7 ferritin ferritin NN cord-010092-uftc8inx 6007 8 levels level NNS cord-010092-uftc8inx 6007 9 were be VBD cord-010092-uftc8inx 6007 10 significantly significantly RB cord-010092-uftc8inx 6007 11 higher high JJR cord-010092-uftc8inx 6007 12 in in IN cord-010092-uftc8inx 6007 13 HH HH NNP cord-010092-uftc8inx 6007 14 patients patient NNS cord-010092-uftc8inx 6007 15 ( ( -LRB- cord-010092-uftc8inx 6007 16 median median NN cord-010092-uftc8inx 6007 17 847.5 847.5 CD cord-010092-uftc8inx 6007 18 , , , cord-010092-uftc8inx 6007 19 range range VBP cord-010092-uftc8inx 6007 20 498 498 CD cord-010092-uftc8inx 6007 21 - - HYPH cord-010092-uftc8inx 6007 22 1889 1889 CD cord-010092-uftc8inx 6007 23 ) ) -RRB- cord-010092-uftc8inx 6007 24 than than IN cord-010092-uftc8inx 6007 25 in in IN cord-010092-uftc8inx 6007 26 controls control NNS cord-010092-uftc8inx 6007 27 ( ( -LRB- cord-010092-uftc8inx 6007 28 median median NN cord-010092-uftc8inx 6007 29 45.8 45.8 CD cord-010092-uftc8inx 6007 30 ng ng NN cord-010092-uftc8inx 6007 31 / / SYM cord-010092-uftc8inx 6007 32 mL ml NN cord-010092-uftc8inx 6007 33 , , , cord-010092-uftc8inx 6007 34 range range VBP cord-010092-uftc8inx 6007 35 9.28 9.28 CD cord-010092-uftc8inx 6007 36 - - SYM cord-010092-uftc8inx 6007 37 97 97 CD cord-010092-uftc8inx 6007 38 ng ng NN cord-010092-uftc8inx 6007 39 / / SYM cord-010092-uftc8inx 6007 40 mL ml NN cord-010092-uftc8inx 6007 41 ) ) -RRB- cord-010092-uftc8inx 6008 1 ( ( -LRB- cord-010092-uftc8inx 6008 2 P p NN cord-010092-uftc8inx 6008 3 < < XX cord-010092-uftc8inx 6008 4 0.001 0.001 CD cord-010092-uftc8inx 6008 5 ) ) -RRB- cord-010092-uftc8inx 6008 6 . . . cord-010092-uftc8inx 6009 1 In in IN cord-010092-uftc8inx 6009 2 the the DT cord-010092-uftc8inx 6009 3 HH HH NNP cord-010092-uftc8inx 6009 4 group group NN cord-010092-uftc8inx 6009 5 , , , cord-010092-uftc8inx 6009 6 5 5 CD cord-010092-uftc8inx 6009 7 each each DT cord-010092-uftc8inx 6009 8 had have VBD cord-010092-uftc8inx 6009 9 the the DT cord-010092-uftc8inx 6009 10 C282Y C282Y NNP cord-010092-uftc8inx 6009 11 / / SYM cord-010092-uftc8inx 6009 12 C282Y C282Y NNP cord-010092-uftc8inx 6009 13 and and CC cord-010092-uftc8inx 6009 14 C282Y C282Y NNP cord-010092-uftc8inx 6009 15 / / SYM cord-010092-uftc8inx 6009 16 H63D h63d NN cord-010092-uftc8inx 6009 17 genotypes genotype NNS cord-010092-uftc8inx 6009 18 . . . cord-010092-uftc8inx 6010 1 Results result NNS cord-010092-uftc8inx 6010 2 of of IN cord-010092-uftc8inx 6010 3 PRP PRP NNP cord-010092-uftc8inx 6010 4 quality quality NN cord-010092-uftc8inx 6010 5 control control NN cord-010092-uftc8inx 6010 6 tests test NNS cord-010092-uftc8inx 6010 7 were be VBD cord-010092-uftc8inx 6010 8 comparable comparable JJ cord-010092-uftc8inx 6010 9 between between IN cord-010092-uftc8inx 6010 10 the the DT cord-010092-uftc8inx 6010 11 two two CD cord-010092-uftc8inx 6010 12 study study NN cord-010092-uftc8inx 6010 13 groups group NNS cord-010092-uftc8inx 6010 14 over over IN cord-010092-uftc8inx 6010 15 seven seven CD cord-010092-uftc8inx 6010 16 days day NNS cord-010092-uftc8inx 6010 17 of of IN cord-010092-uftc8inx 6010 18 storage storage NN cord-010092-uftc8inx 6010 19 ( ( -LRB- cord-010092-uftc8inx 6010 20 P p NN cord-010092-uftc8inx 6010 21 < < XX cord-010092-uftc8inx 6010 22 0.05 0.05 CD cord-010092-uftc8inx 6010 23 ) ) -RRB- cord-010092-uftc8inx 6010 24 with with IN cord-010092-uftc8inx 6010 25 the the DT cord-010092-uftc8inx 6010 26 exception exception NN cord-010092-uftc8inx 6010 27 of of IN cord-010092-uftc8inx 6010 28 glucose glucose NN cord-010092-uftc8inx 6010 29 ( ( -LRB- cord-010092-uftc8inx 6010 30 higher high JJR cord-010092-uftc8inx 6010 31 in in IN cord-010092-uftc8inx 6010 32 HH HH NNP cord-010092-uftc8inx 6010 33 patients patient NNS cord-010092-uftc8inx 6010 34 on on IN cord-010092-uftc8inx 6010 35 all all DT cord-010092-uftc8inx 6010 36 time time NN cord-010092-uftc8inx 6010 37 points point NNS cord-010092-uftc8inx 6010 38 , , , cord-010092-uftc8inx 6010 39 P p NN cord-010092-uftc8inx 6010 40 < < XX cord-010092-uftc8inx 6010 41 0.05 0.05 CD cord-010092-uftc8inx 6010 42 ) ) -RRB- cord-010092-uftc8inx 6010 43 . . . cord-010092-uftc8inx 6011 1 Platelet platelet NN cord-010092-uftc8inx 6011 2 aggregation aggregation NN cord-010092-uftc8inx 6011 3 and and CC cord-010092-uftc8inx 6011 4 the the DT cord-010092-uftc8inx 6011 5 expression expression NN cord-010092-uftc8inx 6011 6 of of IN cord-010092-uftc8inx 6011 7 activation activation NN cord-010092-uftc8inx 6011 8 markers marker NNS cord-010092-uftc8inx 6011 9 ( ( -LRB- cord-010092-uftc8inx 6011 10 CD62p CD62p NNP cord-010092-uftc8inx 6011 11 and and CC cord-010092-uftc8inx 6011 12 CD42b CD42b NNP cord-010092-uftc8inx 6011 13 ) ) -RRB- cord-010092-uftc8inx 6011 14 on on IN cord-010092-uftc8inx 6011 15 platelets platelet NNS cord-010092-uftc8inx 6011 16 and and CC cord-010092-uftc8inx 6011 17 in in IN cord-010092-uftc8inx 6011 18 the the DT cord-010092-uftc8inx 6011 19 supernatant supernatant NN cord-010092-uftc8inx 6011 20 ( ( -LRB- cord-010092-uftc8inx 6011 21 sCD62P sCD62P NNS cord-010092-uftc8inx 6011 22 and and CC cord-010092-uftc8inx 6011 23 CD40L cd40l NN cord-010092-uftc8inx 6011 24 ) ) -RRB- cord-010092-uftc8inx 6011 25 were be VBD cord-010092-uftc8inx 6011 26 comparable comparable JJ cord-010092-uftc8inx 6011 27 between between IN cord-010092-uftc8inx 6011 28 HH hh NN cord-010092-uftc8inx 6011 29 and and CC cord-010092-uftc8inx 6011 30 control control NN cord-010092-uftc8inx 6011 31 PRP PRP NNP cord-010092-uftc8inx 6011 32 units unit NNS cord-010092-uftc8inx 6011 33 over over IN cord-010092-uftc8inx 6011 34 all all DT cord-010092-uftc8inx 6011 35 seven seven CD cord-010092-uftc8inx 6011 36 days day NNS cord-010092-uftc8inx 6011 37 of of IN cord-010092-uftc8inx 6011 38 storage storage NN cord-010092-uftc8inx 6011 39 . . . cord-010092-uftc8inx 6012 1 The the DT cord-010092-uftc8inx 6012 2 analysis analysis NN cord-010092-uftc8inx 6012 3 revealed reveal VBD cord-010092-uftc8inx 6012 4 comparable comparable JJ cord-010092-uftc8inx 6012 5 and and CC cord-010092-uftc8inx 6012 6 expected expect VBN cord-010092-uftc8inx 6012 7 alterations alteration NNS cord-010092-uftc8inx 6012 8 in in IN cord-010092-uftc8inx 6012 9 metabolic metabolic JJ cord-010092-uftc8inx 6012 10 and and CC cord-010092-uftc8inx 6012 11 platelet platelet NN cord-010092-uftc8inx 6012 12 activation activation NN cord-010092-uftc8inx 6012 13 markers marker NNS cord-010092-uftc8inx 6012 14 over over IN cord-010092-uftc8inx 6012 15 seven seven CD cord-010092-uftc8inx 6012 16 - - HYPH cord-010092-uftc8inx 6012 17 day day NN cord-010092-uftc8inx 6012 18 storage storage NN cord-010092-uftc8inx 6012 19 in in IN cord-010092-uftc8inx 6012 20 both both DT cord-010092-uftc8inx 6012 21 groups group NNS cord-010092-uftc8inx 6012 22 . . . cord-010092-uftc8inx 6013 1 pH pH NNP cord-010092-uftc8inx 6013 2 increased increase VBD cord-010092-uftc8inx 6013 3 , , , cord-010092-uftc8inx 6013 4 glucose glucose NN cord-010092-uftc8inx 6013 5 decreased decrease VBD cord-010092-uftc8inx 6013 6 , , , cord-010092-uftc8inx 6013 7 and and CC cord-010092-uftc8inx 6013 8 lactate lactate NN cord-010092-uftc8inx 6013 9 increased increase VBD cord-010092-uftc8inx 6013 10 over over IN cord-010092-uftc8inx 6013 11 time time NN cord-010092-uftc8inx 6013 12 while while IN cord-010092-uftc8inx 6013 13 CD42b CD42b NNP cord-010092-uftc8inx 6013 14 expression expression NN cord-010092-uftc8inx 6013 15 decreased decrease VBD cord-010092-uftc8inx 6013 16 and and CC cord-010092-uftc8inx 6013 17 CD62p CD62p NNP cord-010092-uftc8inx 6013 18 increased increase VBD cord-010092-uftc8inx 6013 19 . . . cord-010092-uftc8inx 6014 1 Platelet platelet NN cord-010092-uftc8inx 6014 2 aggregation aggregation NN cord-010092-uftc8inx 6014 3 responses response NNS cord-010092-uftc8inx 6014 4 decreased decrease VBD cord-010092-uftc8inx 6014 5 during during IN cord-010092-uftc8inx 6014 6 storage storage NN cord-010092-uftc8inx 6014 7 but but CC cord-010092-uftc8inx 6014 8 to to IN cord-010092-uftc8inx 6014 9 a a DT cord-010092-uftc8inx 6014 10 varying vary VBG cord-010092-uftc8inx 6014 11 degree degree NN cord-010092-uftc8inx 6014 12 depending depend VBG cord-010092-uftc8inx 6014 13 on on IN cord-010092-uftc8inx 6014 14 the the DT cord-010092-uftc8inx 6014 15 agonist agonist NN cord-010092-uftc8inx 6014 16 , , , cord-010092-uftc8inx 6014 17 however however RB cord-010092-uftc8inx 6014 18 , , , cord-010092-uftc8inx 6014 19 the the DT cord-010092-uftc8inx 6014 20 decrease decrease NN cord-010092-uftc8inx 6014 21 was be VBD cord-010092-uftc8inx 6014 22 comparable comparable JJ cord-010092-uftc8inx 6014 23 in in IN cord-010092-uftc8inx 6014 24 cases case NNS cord-010092-uftc8inx 6014 25 and and CC cord-010092-uftc8inx 6014 26 controls control NNS cord-010092-uftc8inx 6014 27 . . . cord-010092-uftc8inx 6015 1 Summary Summary NNP cord-010092-uftc8inx 6015 2 / / SYM cord-010092-uftc8inx 6015 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 6015 4 : : : cord-010092-uftc8inx 6016 1 These these DT cord-010092-uftc8inx 6016 2 results result NNS cord-010092-uftc8inx 6016 3 suggest suggest VBP cord-010092-uftc8inx 6016 4 that that IN cord-010092-uftc8inx 6016 5 high high JJ cord-010092-uftc8inx 6016 6 iron iron NN cord-010092-uftc8inx 6016 7 stores store NNS cord-010092-uftc8inx 6016 8 in in IN cord-010092-uftc8inx 6016 9 HH HH NNP cord-010092-uftc8inx 6016 10 do do VBP cord-010092-uftc8inx 6016 11 not not RB cord-010092-uftc8inx 6016 12 adversely adversely RB cord-010092-uftc8inx 6016 13 affect affect VB cord-010092-uftc8inx 6016 14 the the DT cord-010092-uftc8inx 6016 15 quality quality NN cord-010092-uftc8inx 6016 16 of of IN cord-010092-uftc8inx 6016 17 platelet platelet NN cord-010092-uftc8inx 6016 18 units unit NNS cord-010092-uftc8inx 6016 19 produced produce VBN cord-010092-uftc8inx 6016 20 from from IN cord-010092-uftc8inx 6016 21 HH HH NNP cord-010092-uftc8inx 6016 22 patients patient NNS cord-010092-uftc8inx 6016 23 . . . cord-010092-uftc8inx 6017 1 Furthermore furthermore RB cord-010092-uftc8inx 6017 2 , , , cord-010092-uftc8inx 6017 3 the the DT cord-010092-uftc8inx 6017 4 data datum NNS cord-010092-uftc8inx 6017 5 also also RB cord-010092-uftc8inx 6017 6 suggest suggest VBP cord-010092-uftc8inx 6017 7 that that DT cord-010092-uftc8inx 6017 8 blood blood NN cord-010092-uftc8inx 6017 9 from from IN cord-010092-uftc8inx 6017 10 HH HH NNP cord-010092-uftc8inx 6017 11 patients patient NNS cord-010092-uftc8inx 6017 12 , , , cord-010092-uftc8inx 6017 13 including include VBG cord-010092-uftc8inx 6017 14 platelets platelet NNS cord-010092-uftc8inx 6017 15 , , , cord-010092-uftc8inx 6017 16 can can MD cord-010092-uftc8inx 6017 17 be be VB cord-010092-uftc8inx 6017 18 donated donate VBN cord-010092-uftc8inx 6017 19 for for IN cord-010092-uftc8inx 6017 20 patient patient JJ cord-010092-uftc8inx 6017 21 use use NN cord-010092-uftc8inx 6017 22 . . . cord-010092-uftc8inx 6018 1 Background background NN cord-010092-uftc8inx 6018 2 : : : cord-010092-uftc8inx 6019 1 Platelets platelet NNS cord-010092-uftc8inx 6019 2 are be VBP cord-010092-uftc8inx 6019 3 often often RB cord-010092-uftc8inx 6019 4 shipped ship VBN cord-010092-uftc8inx 6019 5 over over IN cord-010092-uftc8inx 6019 6 long long JJ cord-010092-uftc8inx 6019 7 distances distance NNS cord-010092-uftc8inx 6019 8 from from IN cord-010092-uftc8inx 6019 9 collection collection NN cord-010092-uftc8inx 6019 10 centres centre NNS cord-010092-uftc8inx 6019 11 to to IN cord-010092-uftc8inx 6019 12 blood blood NN cord-010092-uftc8inx 6019 13 processing processing NN cord-010092-uftc8inx 6019 14 centres centre NNS cord-010092-uftc8inx 6019 15 and and CC cord-010092-uftc8inx 6019 16 subsequently subsequently RB cord-010092-uftc8inx 6019 17 to to IN cord-010092-uftc8inx 6019 18 hospitals hospital NNS cord-010092-uftc8inx 6019 19 . . . cord-010092-uftc8inx 6020 1 Platelet platelet NN cord-010092-uftc8inx 6020 2 agitation agitation NN cord-010092-uftc8inx 6020 3 facilitates facilitate VBZ cord-010092-uftc8inx 6020 4 oxygen oxygen NN cord-010092-uftc8inx 6020 5 transfer transfer NN cord-010092-uftc8inx 6020 6 , , , cord-010092-uftc8inx 6020 7 thus thus RB cord-010092-uftc8inx 6020 8 promoting promote VBG cord-010092-uftc8inx 6020 9 aerobic aerobic JJ cord-010092-uftc8inx 6020 10 metabolism metabolism NN cord-010092-uftc8inx 6020 11 , , , cord-010092-uftc8inx 6020 12 and and CC cord-010092-uftc8inx 6020 13 maintaining maintain VBG cord-010092-uftc8inx 6020 14 platelet platelet NN cord-010092-uftc8inx 6020 15 pH. ph. NN cord-010092-uftc8inx 6021 1 During during IN cord-010092-uftc8inx 6021 2 shipment shipment NN cord-010092-uftc8inx 6021 3 , , , cord-010092-uftc8inx 6021 4 platelets platelet NNS cord-010092-uftc8inx 6021 5 can can MD cord-010092-uftc8inx 6021 6 not not RB cord-010092-uftc8inx 6021 7 be be VB cord-010092-uftc8inx 6021 8 agitated agitate VBN cord-010092-uftc8inx 6021 9 continuously continuously RB cord-010092-uftc8inx 6021 10 , , , cord-010092-uftc8inx 6021 11 which which WDT cord-010092-uftc8inx 6021 12 may may MD cord-010092-uftc8inx 6021 13 promote promote VB cord-010092-uftc8inx 6021 14 anaerobic anaerobic JJ cord-010092-uftc8inx 6021 15 metabolism metabolism NN cord-010092-uftc8inx 6021 16 . . . cord-010092-uftc8inx 6022 1 Previous previous JJ cord-010092-uftc8inx 6022 2 studies study NNS cord-010092-uftc8inx 6022 3 have have VBP cord-010092-uftc8inx 6022 4 examined examine VBN cord-010092-uftc8inx 6022 5 the the DT cord-010092-uftc8inx 6022 6 effects effect NNS cord-010092-uftc8inx 6022 7 of of IN cord-010092-uftc8inx 6022 8 prolonged prolong VBN cord-010092-uftc8inx 6022 9 periods period NNS cord-010092-uftc8inx 6022 10 without without IN cord-010092-uftc8inx 6022 11 agitation agitation NN cord-010092-uftc8inx 6022 12 on on IN cord-010092-uftc8inx 6022 13 apheresis apheresis NN cord-010092-uftc8inx 6022 14 platelets platelet NNS cord-010092-uftc8inx 6022 15 collected collect VBN cord-010092-uftc8inx 6022 16 in in IN cord-010092-uftc8inx 6022 17 plasma plasma NN cord-010092-uftc8inx 6022 18 , , , cord-010092-uftc8inx 6022 19 but but CC cord-010092-uftc8inx 6022 20 not not RB cord-010092-uftc8inx 6022 21 platelets platelet NNS cord-010092-uftc8inx 6022 22 in in IN cord-010092-uftc8inx 6022 23 platelet platelet NN cord-010092-uftc8inx 6022 24 additive additive NN cord-010092-uftc8inx 6022 25 solution solution NN cord-010092-uftc8inx 6022 26 ( ( -LRB- cord-010092-uftc8inx 6022 27 PAS pas NN cord-010092-uftc8inx 6022 28 ) ) -RRB- cord-010092-uftc8inx 6022 29 . . . cord-010092-uftc8inx 6023 1 It -PRON- PRP cord-010092-uftc8inx 6023 2 is be VBZ cord-010092-uftc8inx 6023 3 therefore therefore RB cord-010092-uftc8inx 6023 4 important important JJ cord-010092-uftc8inx 6023 5 to to TO cord-010092-uftc8inx 6023 6 determine determine VB cord-010092-uftc8inx 6023 7 whether whether IN cord-010092-uftc8inx 6023 8 platelet platelet NN cord-010092-uftc8inx 6023 9 quality quality NN cord-010092-uftc8inx 6023 10 and and CC cord-010092-uftc8inx 6023 11 function function NN cord-010092-uftc8inx 6023 12 are be VBP cord-010092-uftc8inx 6023 13 maintained maintain VBN cord-010092-uftc8inx 6023 14 during during IN cord-010092-uftc8inx 6023 15 prolonged prolonged JJ cord-010092-uftc8inx 6023 16 transport transport NN cord-010092-uftc8inx 6023 17 or or CC cord-010092-uftc8inx 6023 18 hold hold VB cord-010092-uftc8inx 6023 19 time time NN cord-010092-uftc8inx 6023 20 in in IN cord-010092-uftc8inx 6023 21 a a DT cord-010092-uftc8inx 6023 22 shipper shipper NN cord-010092-uftc8inx 6023 23 . . . cord-010092-uftc8inx 6024 1 Aims aim VBZ cord-010092-uftc8inx 6024 2 : : : cord-010092-uftc8inx 6025 1 The the DT cord-010092-uftc8inx 6025 2 aim aim NN cord-010092-uftc8inx 6025 3 of of IN cord-010092-uftc8inx 6025 4 this this DT cord-010092-uftc8inx 6025 5 study study NN cord-010092-uftc8inx 6025 6 was be VBD cord-010092-uftc8inx 6025 7 to to TO cord-010092-uftc8inx 6025 8 evaluate evaluate VB cord-010092-uftc8inx 6025 9 the the DT cord-010092-uftc8inx 6025 10 effects effect NNS cord-010092-uftc8inx 6025 11 of of IN cord-010092-uftc8inx 6025 12 prolonged prolonged JJ cord-010092-uftc8inx 6025 13 storage storage NN cord-010092-uftc8inx 6025 14 without without IN cord-010092-uftc8inx 6025 15 agitation agitation NN cord-010092-uftc8inx 6025 16 on on IN cord-010092-uftc8inx 6025 17 the the DT cord-010092-uftc8inx 6025 18 in in FW cord-010092-uftc8inx 6025 19 vitro vitro FW cord-010092-uftc8inx 6025 20 quality quality NN cord-010092-uftc8inx 6025 21 of of IN cord-010092-uftc8inx 6025 22 apheresis apheresis NN cord-010092-uftc8inx 6025 23 platelets platelet NNS cord-010092-uftc8inx 6025 24 in in IN cord-010092-uftc8inx 6025 25 PAS pas NN cord-010092-uftc8inx 6025 26 . . . cord-010092-uftc8inx 6026 1 Methods method NNS cord-010092-uftc8inx 6026 2 : : : cord-010092-uftc8inx 6027 1 Triple triple JJ cord-010092-uftc8inx 6027 2 dose dose NN cord-010092-uftc8inx 6027 3 apheresis apheresis NN cord-010092-uftc8inx 6027 4 platelets platelet NNS cord-010092-uftc8inx 6028 1 ( ( -LRB- cord-010092-uftc8inx 6028 2 n n NN cord-010092-uftc8inx 6028 3 = = SYM cord-010092-uftc8inx 6028 4 16 16 CD cord-010092-uftc8inx 6028 5 ) ) -RRB- cord-010092-uftc8inx 6028 6 were be VBD cord-010092-uftc8inx 6028 7 collected collect VBN cord-010092-uftc8inx 6028 8 using use VBG cord-010092-uftc8inx 6028 9 a a DT cord-010092-uftc8inx 6028 10 TRIMA TRIMA NNP cord-010092-uftc8inx 6028 11 Accel Accel NNP cord-010092-uftc8inx 6028 12 platform platform NN cord-010092-uftc8inx 6028 13 in in IN cord-010092-uftc8inx 6028 14 40 40 CD cord-010092-uftc8inx 6028 15 % % NN cord-010092-uftc8inx 6028 16 plasma/60 plasma/60 NN cord-010092-uftc8inx 6028 17 % % NN cord-010092-uftc8inx 6028 18 PAS pas NN cord-010092-uftc8inx 6028 19 ( ( -LRB- cord-010092-uftc8inx 6028 20 SSP+ SSP+ NNP cord-010092-uftc8inx 6028 21 ) ) -RRB- cord-010092-uftc8inx 6028 22 . . . cord-010092-uftc8inx 6029 1 After after IN cord-010092-uftc8inx 6029 2 resting rest VBG cord-010092-uftc8inx 6029 3 for for IN cord-010092-uftc8inx 6029 4 1 1 CD cord-010092-uftc8inx 6029 5 h h NN cord-010092-uftc8inx 6029 6 , , , cord-010092-uftc8inx 6029 7 platelets platelet NNS cord-010092-uftc8inx 6029 8 were be VBD cord-010092-uftc8inx 6029 9 split split VBN cord-010092-uftc8inx 6029 10 equally equally RB cord-010092-uftc8inx 6029 11 into into IN cord-010092-uftc8inx 6029 12 three three CD cord-010092-uftc8inx 6029 13 components component NNS cord-010092-uftc8inx 6029 14 , , , cord-010092-uftc8inx 6029 15 packed pack VBN cord-010092-uftc8inx 6029 16 into into IN cord-010092-uftc8inx 6029 17 a a DT cord-010092-uftc8inx 6029 18 shipper shipper NN cord-010092-uftc8inx 6029 19 and and CC cord-010092-uftc8inx 6029 20 transported transport VBD cord-010092-uftc8inx 6029 21 immediately immediately RB cord-010092-uftc8inx 6029 22 to to IN cord-010092-uftc8inx 6029 23 the the DT cord-010092-uftc8inx 6029 24 blood blood NN cord-010092-uftc8inx 6029 25 centre centre NN cord-010092-uftc8inx 6029 26 . . . cord-010092-uftc8inx 6030 1 Upon upon IN cord-010092-uftc8inx 6030 2 arrival arrival NN cord-010092-uftc8inx 6030 3 , , , cord-010092-uftc8inx 6030 4 one one CD cord-010092-uftc8inx 6030 5 of of IN cord-010092-uftc8inx 6030 6 the the DT cord-010092-uftc8inx 6030 7 platelet platelet NN cord-010092-uftc8inx 6030 8 components component NNS cord-010092-uftc8inx 6030 9 was be VBD cord-010092-uftc8inx 6030 10 removed remove VBN cord-010092-uftc8inx 6030 11 ( ( -LRB- cord-010092-uftc8inx 6030 12 < < NNP cord-010092-uftc8inx 6030 13 6 6 CD cord-010092-uftc8inx 6030 14 h h NN cord-010092-uftc8inx 6030 15 ; ; : cord-010092-uftc8inx 6030 16 T0 T0 NNP cord-010092-uftc8inx 6030 17 ) ) -RRB- cord-010092-uftc8inx 6030 18 , , , cord-010092-uftc8inx 6030 19 and and CC cord-010092-uftc8inx 6030 20 the the DT cord-010092-uftc8inx 6030 21 others other NNS cord-010092-uftc8inx 6030 22 remained remain VBD cord-010092-uftc8inx 6030 23 within within IN cord-010092-uftc8inx 6030 24 the the DT cord-010092-uftc8inx 6030 25 shipper shipper NN cord-010092-uftc8inx 6030 26 , , , cord-010092-uftc8inx 6030 27 without without IN cord-010092-uftc8inx 6030 28 agitation agitation NN cord-010092-uftc8inx 6030 29 . . . cord-010092-uftc8inx 6031 1 The the DT cord-010092-uftc8inx 6031 2 second second JJ cord-010092-uftc8inx 6031 3 component component NN cord-010092-uftc8inx 6031 4 was be VBD cord-010092-uftc8inx 6031 5 removed remove VBN cord-010092-uftc8inx 6031 6 at at IN cord-010092-uftc8inx 6031 7 6 6 CD cord-010092-uftc8inx 6031 8 h h NN cord-010092-uftc8inx 6031 9 post post NN cord-010092-uftc8inx 6031 10 - - NN cord-010092-uftc8inx 6031 11 collection collection JJ cord-010092-uftc8inx 6031 12 ( ( -LRB- cord-010092-uftc8inx 6031 13 T6 T6 NNP cord-010092-uftc8inx 6031 14 ) ) -RRB- cord-010092-uftc8inx 6031 15 , , , cord-010092-uftc8inx 6031 16 and and CC cord-010092-uftc8inx 6031 17 the the DT cord-010092-uftc8inx 6031 18 third third JJ cord-010092-uftc8inx 6031 19 was be VBD cord-010092-uftc8inx 6031 20 removed remove VBN cord-010092-uftc8inx 6031 21 at at IN cord-010092-uftc8inx 6031 22 23.5 23.5 CD cord-010092-uftc8inx 6031 23 h h NNP cord-010092-uftc8inx 6031 24 post post NN cord-010092-uftc8inx 6031 25 - - NN cord-010092-uftc8inx 6031 26 collection collection JJ cord-010092-uftc8inx 6031 27 ( ( -LRB- cord-010092-uftc8inx 6031 28 rounded round VBN cord-010092-uftc8inx 6031 29 up up RP cord-010092-uftc8inx 6031 30 to to IN cord-010092-uftc8inx 6031 31 24 24 CD cord-010092-uftc8inx 6031 32 h h NN cord-010092-uftc8inx 6031 33 ; ; : cord-010092-uftc8inx 6031 34 T24 T24 NNP cord-010092-uftc8inx 6031 35 ) ) -RRB- cord-010092-uftc8inx 6031 36 . . . cord-010092-uftc8inx 6032 1 Platelets platelet NNS cord-010092-uftc8inx 6032 2 were be VBD cord-010092-uftc8inx 6032 3 tested test VBN cord-010092-uftc8inx 6032 4 on on IN cord-010092-uftc8inx 6032 5 day day NN cord-010092-uftc8inx 6032 6 1 1 CD cord-010092-uftc8inx 6032 7 , , , cord-010092-uftc8inx 6032 8 5 5 CD cord-010092-uftc8inx 6032 9 and and CC cord-010092-uftc8inx 6032 10 7 7 CD cord-010092-uftc8inx 6032 11 post post NN cord-010092-uftc8inx 6032 12 - - NN cord-010092-uftc8inx 6032 13 collection collection JJ cord-010092-uftc8inx 6032 14 and and CC cord-010092-uftc8inx 6032 15 in in IN cord-010092-uftc8inx 6032 16 vitro vitro FW cord-010092-uftc8inx 6032 17 quality quality NN cord-010092-uftc8inx 6032 18 and and CC cord-010092-uftc8inx 6032 19 function function NN cord-010092-uftc8inx 6032 20 were be VBD cord-010092-uftc8inx 6032 21 monitored monitor VBN cord-010092-uftc8inx 6032 22 . . . cord-010092-uftc8inx 6033 1 Data datum NNS cord-010092-uftc8inx 6033 2 were be VBD cord-010092-uftc8inx 6033 3 analysed analyse VBN cord-010092-uftc8inx 6033 4 using use VBG cord-010092-uftc8inx 6033 5 a a DT cord-010092-uftc8inx 6033 6 two two CD cord-010092-uftc8inx 6033 7 - - HYPH cord-010092-uftc8inx 6033 8 way way NN cord-010092-uftc8inx 6033 9 repeated repeat VBN cord-010092-uftc8inx 6033 10 measures measure NNS cord-010092-uftc8inx 6033 11 ANOVA ANOVA NNP cord-010092-uftc8inx 6033 12 , , , cord-010092-uftc8inx 6033 13 where where WRB cord-010092-uftc8inx 6033 14 a a DT cord-010092-uftc8inx 6033 15 P p NN cord-010092-uftc8inx 6033 16 - - HYPH cord-010092-uftc8inx 6033 17 value value NN cord-010092-uftc8inx 6033 18 of of IN cord-010092-uftc8inx 6033 19 < < NNP cord-010092-uftc8inx 6033 20 0.01 0.01 CD cord-010092-uftc8inx 6033 21 was be VBD cord-010092-uftc8inx 6033 22 considered consider VBN cord-010092-uftc8inx 6033 23 significant significant JJ cord-010092-uftc8inx 6033 24 . . . cord-010092-uftc8inx 6034 1 Results result NNS cord-010092-uftc8inx 6034 2 : : : cord-010092-uftc8inx 6034 3 Platelets platelet NNS cord-010092-uftc8inx 6034 4 held hold VBD cord-010092-uftc8inx 6034 5 without without IN cord-010092-uftc8inx 6034 6 agitation agitation NN cord-010092-uftc8inx 6034 7 for for IN cord-010092-uftc8inx 6034 8 24 24 CD cord-010092-uftc8inx 6034 9 h h NN cord-010092-uftc8inx 6034 10 consumed consume VBD cord-010092-uftc8inx 6034 11 significantly significantly RB cord-010092-uftc8inx 6034 12 more more JJR cord-010092-uftc8inx 6034 13 glucose glucose NN cord-010092-uftc8inx 6034 14 than than IN cord-010092-uftc8inx 6034 15 those those DT cord-010092-uftc8inx 6034 16 removed remove VBN cord-010092-uftc8inx 6034 17 at at IN cord-010092-uftc8inx 6034 18 6 6 CD cord-010092-uftc8inx 6034 19 h h NN cord-010092-uftc8inx 6034 20 or or CC cord-010092-uftc8inx 6034 21 immediately immediately RB cord-010092-uftc8inx 6034 22 upon upon IN cord-010092-uftc8inx 6034 23 arrival arrival NN cord-010092-uftc8inx 6034 24 ( ( -LRB- cord-010092-uftc8inx 6034 25 P p NN cord-010092-uftc8inx 6034 26 < < XX cord-010092-uftc8inx 6034 27 0.0001 0.0001 CD cord-010092-uftc8inx 6034 28 ) ) -RRB- cord-010092-uftc8inx 6034 29 , , , cord-010092-uftc8inx 6034 30 even even RB cord-010092-uftc8inx 6034 31 on on IN cord-010092-uftc8inx 6034 32 day day NN cord-010092-uftc8inx 6034 33 1 1 CD cord-010092-uftc8inx 6034 34 post post NN cord-010092-uftc8inx 6034 35 - - NN cord-010092-uftc8inx 6034 36 collection collection NN cord-010092-uftc8inx 6034 37 . . . cord-010092-uftc8inx 6035 1 This this DT cord-010092-uftc8inx 6035 2 was be VBD cord-010092-uftc8inx 6035 3 accompanied accompany VBN cord-010092-uftc8inx 6035 4 by by IN cord-010092-uftc8inx 6035 5 increased increase VBN cord-010092-uftc8inx 6035 6 lactate lactate NN cord-010092-uftc8inx 6035 7 production production NN cord-010092-uftc8inx 6035 8 ( ( -LRB- cord-010092-uftc8inx 6035 9 P p NN cord-010092-uftc8inx 6035 10 < < XX cord-010092-uftc8inx 6035 11 0.0001 0.0001 CD cord-010092-uftc8inx 6035 12 ) ) -RRB- cord-010092-uftc8inx 6035 13 , , , cord-010092-uftc8inx 6035 14 indicating indicate VBG cord-010092-uftc8inx 6035 15 increased increase VBN cord-010092-uftc8inx 6035 16 anaerobic anaerobic JJ cord-010092-uftc8inx 6035 17 glycolysis glycolysis NN cord-010092-uftc8inx 6035 18 . . . cord-010092-uftc8inx 6036 1 Consequently consequently RB cord-010092-uftc8inx 6036 2 , , , cord-010092-uftc8inx 6036 3 the the DT cord-010092-uftc8inx 6036 4 pH pH NNP cord-010092-uftc8inx 6036 5 was be VBD cord-010092-uftc8inx 6036 6 significantly significantly RB cord-010092-uftc8inx 6036 7 lower low JJR cord-010092-uftc8inx 6036 8 in in IN cord-010092-uftc8inx 6036 9 T24 T24 NNP cord-010092-uftc8inx 6036 10 platelets platelet NNS cord-010092-uftc8inx 6036 11 ( ( -LRB- cord-010092-uftc8inx 6036 12 P p NN cord-010092-uftc8inx 6036 13 < < XX cord-010092-uftc8inx 6036 14 0.0001 0.0001 CD cord-010092-uftc8inx 6036 15 ) ) -RRB- cord-010092-uftc8inx 6036 16 , , , cord-010092-uftc8inx 6036 17 and and CC cord-010092-uftc8inx 6036 18 on on IN cord-010092-uftc8inx 6036 19 average average JJ cord-010092-uftc8inx 6036 20 it -PRON- PRP cord-010092-uftc8inx 6036 21 was be VBD cord-010092-uftc8inx 6036 22 0.4 0.4 CD cord-010092-uftc8inx 6036 23 pH ph NN cord-010092-uftc8inx 6036 24 units unit NNS cord-010092-uftc8inx 6036 25 lower low JJR cord-010092-uftc8inx 6036 26 than than IN cord-010092-uftc8inx 6036 27 in in IN cord-010092-uftc8inx 6036 28 platelets platelet NNS cord-010092-uftc8inx 6036 29 held hold VBN cord-010092-uftc8inx 6036 30 in in IN cord-010092-uftc8inx 6036 31 the the DT cord-010092-uftc8inx 6036 32 shipper shipper NN cord-010092-uftc8inx 6036 33 for for IN cord-010092-uftc8inx 6036 34 6 6 CD cord-010092-uftc8inx 6036 35 h h NN cord-010092-uftc8inx 6036 36 or or CC cord-010092-uftc8inx 6036 37 less less JJR cord-010092-uftc8inx 6036 38 . . . cord-010092-uftc8inx 6037 1 However however RB cord-010092-uftc8inx 6037 2 , , , cord-010092-uftc8inx 6037 3 the the DT cord-010092-uftc8inx 6037 4 pH pH NNP cord-010092-uftc8inx 6037 5 remained remain VBD cord-010092-uftc8inx 6037 6 above above IN cord-010092-uftc8inx 6037 7 6.9 6.9 CD cord-010092-uftc8inx 6037 8 in in IN cord-010092-uftc8inx 6037 9 all all DT cord-010092-uftc8inx 6037 10 components component NNS cord-010092-uftc8inx 6037 11 . . . cord-010092-uftc8inx 6038 1 Mean mean JJ cord-010092-uftc8inx 6038 2 platelet platelet NN cord-010092-uftc8inx 6038 3 volume volume NN cord-010092-uftc8inx 6038 4 was be VBD cord-010092-uftc8inx 6038 5 also also RB cord-010092-uftc8inx 6038 6 reduced reduce VBN cord-010092-uftc8inx 6038 7 in in IN cord-010092-uftc8inx 6038 8 T24 T24 NNP cord-010092-uftc8inx 6038 9 platelets platelet NNS cord-010092-uftc8inx 6038 10 ( ( -LRB- cord-010092-uftc8inx 6038 11 P p NN cord-010092-uftc8inx 6038 12 < < XX cord-010092-uftc8inx 6038 13 0.0001 0.0001 CD cord-010092-uftc8inx 6038 14 ) ) -RRB- cord-010092-uftc8inx 6038 15 , , , cord-010092-uftc8inx 6038 16 suggesting suggest VBG cord-010092-uftc8inx 6038 17 acceleration acceleration NN cord-010092-uftc8inx 6038 18 of of IN cord-010092-uftc8inx 6038 19 the the DT cord-010092-uftc8inx 6038 20 platelet platelet NN cord-010092-uftc8inx 6038 21 storage storage NN cord-010092-uftc8inx 6038 22 lesion lesion NN cord-010092-uftc8inx 6038 23 . . . cord-010092-uftc8inx 6039 1 Phosphatidylserine phosphatidylserine NN cord-010092-uftc8inx 6039 2 exposure exposure NN cord-010092-uftc8inx 6039 3 , , , cord-010092-uftc8inx 6039 4 surface surface NN cord-010092-uftc8inx 6039 5 expression expression NN cord-010092-uftc8inx 6039 6 of of IN cord-010092-uftc8inx 6039 7 CD62P CD62P NNP cord-010092-uftc8inx 6039 8 and and CC cord-010092-uftc8inx 6039 9 microparticle microparticle NNP cord-010092-uftc8inx 6039 10 generation generation NN cord-010092-uftc8inx 6039 11 were be VBD cord-010092-uftc8inx 6039 12 significantly significantly RB cord-010092-uftc8inx 6039 13 higher high JJR cord-010092-uftc8inx 6039 14 in in IN cord-010092-uftc8inx 6039 15 the the DT cord-010092-uftc8inx 6039 16 T24 T24 NNP cord-010092-uftc8inx 6039 17 platelets platelet NNS cord-010092-uftc8inx 6039 18 throughout throughout IN cord-010092-uftc8inx 6039 19 the the DT cord-010092-uftc8inx 6039 20 storage storage NN cord-010092-uftc8inx 6039 21 period period NN cord-010092-uftc8inx 6039 22 ( ( -LRB- cord-010092-uftc8inx 6039 23 all all DT cord-010092-uftc8inx 6039 24 P p NN cord-010092-uftc8inx 6039 25 < < XX cord-010092-uftc8inx 6039 26 0.0001 0.0001 CD cord-010092-uftc8inx 6039 27 ) ) -RRB- cord-010092-uftc8inx 6039 28 , , , cord-010092-uftc8inx 6039 29 suggesting suggest VBG cord-010092-uftc8inx 6039 30 platelet platelet NN cord-010092-uftc8inx 6039 31 activation activation NN cord-010092-uftc8inx 6039 32 . . . cord-010092-uftc8inx 6040 1 Release release NN cord-010092-uftc8inx 6040 2 of of IN cord-010092-uftc8inx 6040 3 sCD62P sCD62P NNP cord-010092-uftc8inx 6040 4 was be VBD cord-010092-uftc8inx 6040 5 also also RB cord-010092-uftc8inx 6040 6 increased increase VBN cord-010092-uftc8inx 6040 7 in in IN cord-010092-uftc8inx 6040 8 T24 T24 NNP cord-010092-uftc8inx 6040 9 platelets platelet NNS cord-010092-uftc8inx 6040 10 ( ( -LRB- cord-010092-uftc8inx 6040 11 P p NN cord-010092-uftc8inx 6040 12 = = SYM cord-010092-uftc8inx 6040 13 0.0006 0.0006 CD cord-010092-uftc8inx 6040 14 ) ) -RRB- cord-010092-uftc8inx 6040 15 , , , cord-010092-uftc8inx 6040 16 whereas whereas IN cord-010092-uftc8inx 6040 17 extended extended JJ cord-010092-uftc8inx 6040 18 storage storage NN cord-010092-uftc8inx 6040 19 in in IN cord-010092-uftc8inx 6040 20 a a DT cord-010092-uftc8inx 6040 21 shipper shipper NN cord-010092-uftc8inx 6040 22 did do VBD cord-010092-uftc8inx 6040 23 not not RB cord-010092-uftc8inx 6040 24 affect affect VB cord-010092-uftc8inx 6040 25 release release NN cord-010092-uftc8inx 6040 26 of of IN cord-010092-uftc8inx 6040 27 RANTES RANTES NNP cord-010092-uftc8inx 6040 28 ( ( -LRB- cord-010092-uftc8inx 6040 29 P p NN cord-010092-uftc8inx 6040 30 = = SYM cord-010092-uftc8inx 6040 31 0.4488 0.4488 CD cord-010092-uftc8inx 6040 32 ) ) -RRB- cord-010092-uftc8inx 6040 33 . . . cord-010092-uftc8inx 6041 1 ADP ADP NNP cord-010092-uftc8inx 6041 2 - - HYPH cord-010092-uftc8inx 6041 3 induced induce VBN cord-010092-uftc8inx 6041 4 activation activation NN cord-010092-uftc8inx 6041 5 of of IN cord-010092-uftc8inx 6041 6 glycoprotein glycoprotein NN cord-010092-uftc8inx 6041 7 IIb IIb NNP cord-010092-uftc8inx 6041 8 / / SYM cord-010092-uftc8inx 6041 9 IIIa IIIa NNS cord-010092-uftc8inx 6041 10 , , , cord-010092-uftc8inx 6041 11 measured measure VBN cord-010092-uftc8inx 6041 12 by by IN cord-010092-uftc8inx 6041 13 PAC-1 PAC-1 NNS cord-010092-uftc8inx 6041 14 binding bind VBG cord-010092-uftc8inx 6041 15 , , , cord-010092-uftc8inx 6041 16 was be VBD cord-010092-uftc8inx 6041 17 decreased decrease VBN cord-010092-uftc8inx 6041 18 in in IN cord-010092-uftc8inx 6041 19 T24 T24 NNP cord-010092-uftc8inx 6041 20 platelets platelet NNS cord-010092-uftc8inx 6041 21 ( ( -LRB- cord-010092-uftc8inx 6041 22 P p NN cord-010092-uftc8inx 6041 23 < < XX cord-010092-uftc8inx 6041 24 0.0001 0.0001 CD cord-010092-uftc8inx 6041 25 ) ) -RRB- cord-010092-uftc8inx 6041 26 , , , cord-010092-uftc8inx 6041 27 indicating indicate VBG cord-010092-uftc8inx 6041 28 reduced reduce VBN cord-010092-uftc8inx 6041 29 platelet platelet NN cord-010092-uftc8inx 6041 30 responsiveness responsiveness NN cord-010092-uftc8inx 6041 31 to to IN cord-010092-uftc8inx 6041 32 agonist agonist JJ cord-010092-uftc8inx 6041 33 stimulation stimulation NN cord-010092-uftc8inx 6041 34 . . . cord-010092-uftc8inx 6042 1 Additionally additionally RB cord-010092-uftc8inx 6042 2 aggregation aggregation NN cord-010092-uftc8inx 6042 3 in in IN cord-010092-uftc8inx 6042 4 response response NN cord-010092-uftc8inx 6042 5 to to IN cord-010092-uftc8inx 6042 6 collagen collagen NN cord-010092-uftc8inx 6042 7 ( ( -LRB- cord-010092-uftc8inx 6042 8 P p NN cord-010092-uftc8inx 6042 9 = = SYM cord-010092-uftc8inx 6042 10 0.0001 0.0001 CD cord-010092-uftc8inx 6042 11 ) ) -RRB- cord-010092-uftc8inx 6042 12 and and CC cord-010092-uftc8inx 6042 13 ADP ADP NNP cord-010092-uftc8inx 6042 14 ( ( -LRB- cord-010092-uftc8inx 6042 15 P p NN cord-010092-uftc8inx 6042 16 = = SYM cord-010092-uftc8inx 6042 17 0.003 0.003 CD cord-010092-uftc8inx 6042 18 ) ) -RRB- cord-010092-uftc8inx 6042 19 were be VBD cord-010092-uftc8inx 6042 20 significantly significantly RB cord-010092-uftc8inx 6042 21 lower low JJR cord-010092-uftc8inx 6042 22 in in IN cord-010092-uftc8inx 6042 23 T24 T24 NNP cord-010092-uftc8inx 6042 24 platelets platelet NNS cord-010092-uftc8inx 6042 25 , , , cord-010092-uftc8inx 6042 26 suggesting suggest VBG cord-010092-uftc8inx 6042 27 a a DT cord-010092-uftc8inx 6042 28 decrement decrement NN cord-010092-uftc8inx 6042 29 in in IN cord-010092-uftc8inx 6042 30 platelet platelet NN cord-010092-uftc8inx 6042 31 function function NN cord-010092-uftc8inx 6042 32 after after IN cord-010092-uftc8inx 6042 33 prolonged prolong VBN cord-010092-uftc8inx 6042 34 storage storage NN cord-010092-uftc8inx 6042 35 without without IN cord-010092-uftc8inx 6042 36 agitation agitation NN cord-010092-uftc8inx 6042 37 . . . cord-010092-uftc8inx 6043 1 Summary Summary NNP cord-010092-uftc8inx 6043 2 / / SYM cord-010092-uftc8inx 6043 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 6043 4 : : : cord-010092-uftc8inx 6044 1 Significant significant JJ cord-010092-uftc8inx 6044 2 in in IN cord-010092-uftc8inx 6044 3 vitro vitro FW cord-010092-uftc8inx 6044 4 changes change NNS cord-010092-uftc8inx 6044 5 were be VBD cord-010092-uftc8inx 6044 6 observed observe VBN cord-010092-uftc8inx 6044 7 in in IN cord-010092-uftc8inx 6044 8 platelets platelet NNS cord-010092-uftc8inx 6044 9 held hold VBN cord-010092-uftc8inx 6044 10 without without IN cord-010092-uftc8inx 6044 11 agitation agitation NN cord-010092-uftc8inx 6044 12 for for IN cord-010092-uftc8inx 6044 13 24 24 CD cord-010092-uftc8inx 6044 14 h. h. NN cord-010092-uftc8inx 6045 1 These these DT cord-010092-uftc8inx 6045 2 results result NNS cord-010092-uftc8inx 6045 3 suggest suggest VBP cord-010092-uftc8inx 6045 4 that that IN cord-010092-uftc8inx 6045 5 the the DT cord-010092-uftc8inx 6045 6 length length NN cord-010092-uftc8inx 6045 7 of of IN cord-010092-uftc8inx 6045 8 time time NN cord-010092-uftc8inx 6045 9 that that WDT cord-010092-uftc8inx 6045 10 platelets platelet NNS cord-010092-uftc8inx 6045 11 are be VBP cord-010092-uftc8inx 6045 12 held hold VBN cord-010092-uftc8inx 6045 13 in in IN cord-010092-uftc8inx 6045 14 a a DT cord-010092-uftc8inx 6045 15 shipper shipper NN cord-010092-uftc8inx 6045 16 should should MD cord-010092-uftc8inx 6045 17 be be VB cord-010092-uftc8inx 6045 18 minimised minimise VBN cord-010092-uftc8inx 6045 19 where where WRB cord-010092-uftc8inx 6045 20 possible possible JJ cord-010092-uftc8inx 6045 21 . . . cord-010092-uftc8inx 6045 22 _SP cord-010092-uftc8inx 6046 1 Background background NN cord-010092-uftc8inx 6046 2 : : : cord-010092-uftc8inx 6047 1 The the DT cord-010092-uftc8inx 6047 2 shelf shelf NN cord-010092-uftc8inx 6047 3 - - HYPH cord-010092-uftc8inx 6047 4 life life NN cord-010092-uftc8inx 6047 5 for for IN cord-010092-uftc8inx 6047 6 platelet platelet NN cord-010092-uftc8inx 6047 7 products product NNS cord-010092-uftc8inx 6047 8 has have VBZ cord-010092-uftc8inx 6047 9 been be VBN cord-010092-uftc8inx 6047 10 restricted restrict VBN cord-010092-uftc8inx 6047 11 to to IN cord-010092-uftc8inx 6047 12 5 5 CD cord-010092-uftc8inx 6047 13 days day NNS cord-010092-uftc8inx 6047 14 . . . cord-010092-uftc8inx 6048 1 This this DT cord-010092-uftc8inx 6048 2 very very RB cord-010092-uftc8inx 6048 3 limited limited JJ cord-010092-uftc8inx 6048 4 window window NN cord-010092-uftc8inx 6048 5 of of IN cord-010092-uftc8inx 6048 6 time time NN cord-010092-uftc8inx 6048 7 is be VBZ cord-010092-uftc8inx 6048 8 intended intend VBN cord-010092-uftc8inx 6048 9 to to TO cord-010092-uftc8inx 6048 10 sustain sustain VB cord-010092-uftc8inx 6048 11 the the DT cord-010092-uftc8inx 6048 12 quality quality NN cord-010092-uftc8inx 6048 13 of of IN cord-010092-uftc8inx 6048 14 platelet platelet NN cord-010092-uftc8inx 6048 15 and and CC cord-010092-uftc8inx 6048 16 to to TO cord-010092-uftc8inx 6048 17 reduce reduce VB cord-010092-uftc8inx 6048 18 the the DT cord-010092-uftc8inx 6048 19 risk risk NN cord-010092-uftc8inx 6048 20 of of IN cord-010092-uftc8inx 6048 21 bacterial bacterial JJ cord-010092-uftc8inx 6048 22 growth growth NN cord-010092-uftc8inx 6048 23 . . . cord-010092-uftc8inx 6049 1 We -PRON- PRP cord-010092-uftc8inx 6049 2 have have VBP cord-010092-uftc8inx 6049 3 recently recently RB cord-010092-uftc8inx 6049 4 demonstrated demonstrate VBN cord-010092-uftc8inx 6049 5 that that IN cord-010092-uftc8inx 6049 6 in in IN cord-010092-uftc8inx 6049 7 suitable suitable JJ cord-010092-uftc8inx 6049 8 platelet platelet NN cord-010092-uftc8inx 6049 9 bags bag NNS cord-010092-uftc8inx 6049 10 , , , cord-010092-uftc8inx 6049 11 the the DT cord-010092-uftc8inx 6049 12 platelet platelet NN cord-010092-uftc8inx 6049 13 product product NN cord-010092-uftc8inx 6049 14 quality quality NN cord-010092-uftc8inx 6049 15 remains remain VBZ cord-010092-uftc8inx 6049 16 high high JJ cord-010092-uftc8inx 6049 17 after after IN cord-010092-uftc8inx 6049 18 5 5 CD cord-010092-uftc8inx 6049 19 days day NNS cord-010092-uftc8inx 6049 20 of of IN cord-010092-uftc8inx 6049 21 storage storage NN cord-010092-uftc8inx 6049 22 . . . cord-010092-uftc8inx 6050 1 This this DT cord-010092-uftc8inx 6050 2 was be VBD cord-010092-uftc8inx 6050 3 proved prove VBN cord-010092-uftc8inx 6050 4 by by IN cord-010092-uftc8inx 6050 5 examining examine VBG cord-010092-uftc8inx 6050 6 in in IN cord-010092-uftc8inx 6050 7 vitro vitro FW cord-010092-uftc8inx 6050 8 , , , cord-010092-uftc8inx 6050 9 the the DT cord-010092-uftc8inx 6050 10 quality quality NN cord-010092-uftc8inx 6050 11 parameters parameter NNS cord-010092-uftc8inx 6050 12 of of IN cord-010092-uftc8inx 6050 13 platelets platelet NNS cord-010092-uftc8inx 6050 14 such such JJ cord-010092-uftc8inx 6050 15 as as IN cord-010092-uftc8inx 6050 16 platelet platelet NN cord-010092-uftc8inx 6050 17 concentration concentration NN cord-010092-uftc8inx 6050 18 , , , cord-010092-uftc8inx 6050 19 glucose glucose NN cord-010092-uftc8inx 6050 20 , , , cord-010092-uftc8inx 6050 21 LDH LDH NNP cord-010092-uftc8inx 6050 22 , , , cord-010092-uftc8inx 6050 23 and and CC cord-010092-uftc8inx 6050 24 pH pH NNP cord-010092-uftc8inx 6051 1 ( ( -LRB- cord-010092-uftc8inx 6051 2 Alexopoulos Alexopoulos NNP cord-010092-uftc8inx 6051 3 K. K. NNP cord-010092-uftc8inx 6051 4 et et NNP cord-010092-uftc8inx 6051 5 al al NNP cord-010092-uftc8inx 6051 6 . . . cord-010092-uftc8inx 6052 1 , , , cord-010092-uftc8inx 6052 2 Haema Haema NNP cord-010092-uftc8inx 6052 3 , , , cord-010092-uftc8inx 6052 4 9 9 CD cord-010092-uftc8inx 6052 5 , , , cord-010092-uftc8inx 6052 6 2018 2018 CD cord-010092-uftc8inx 6052 7 ) ) -RRB- cord-010092-uftc8inx 6052 8 . . . cord-010092-uftc8inx 6053 1 Our -PRON- PRP$ cord-010092-uftc8inx 6053 2 new new JJ cord-010092-uftc8inx 6053 3 target target NN cord-010092-uftc8inx 6053 4 is be VBZ cord-010092-uftc8inx 6053 5 to to TO cord-010092-uftc8inx 6053 6 extend extend VB cord-010092-uftc8inx 6053 7 this this DT cord-010092-uftc8inx 6053 8 research research NN cord-010092-uftc8inx 6053 9 in in IN cord-010092-uftc8inx 6053 10 2 2 CD cord-010092-uftc8inx 6053 11 extra extra JJ cord-010092-uftc8inx 6053 12 days day NNS cord-010092-uftc8inx 6053 13 of of IN cord-010092-uftc8inx 6053 14 storage storage NN cord-010092-uftc8inx 6053 15 . . . cord-010092-uftc8inx 6054 1 We -PRON- PRP cord-010092-uftc8inx 6054 2 also also RB cord-010092-uftc8inx 6054 3 want want VBP cord-010092-uftc8inx 6054 4 to to TO cord-010092-uftc8inx 6054 5 determine determine VB cord-010092-uftc8inx 6054 6 if if IN cord-010092-uftc8inx 6054 7 there there EX cord-010092-uftc8inx 6054 8 is be VBZ cord-010092-uftc8inx 6054 9 any any DT cord-010092-uftc8inx 6054 10 bacterial bacterial JJ cord-010092-uftc8inx 6054 11 development development NN cord-010092-uftc8inx 6054 12 in in IN cord-010092-uftc8inx 6054 13 this this DT cord-010092-uftc8inx 6054 14 period period NN cord-010092-uftc8inx 6054 15 . . . cord-010092-uftc8inx 6055 1 Aims aim VBZ cord-010092-uftc8inx 6055 2 : : : cord-010092-uftc8inx 6056 1 The the DT cord-010092-uftc8inx 6056 2 goal goal NN cord-010092-uftc8inx 6056 3 is be VBZ cord-010092-uftc8inx 6056 4 to to TO cord-010092-uftc8inx 6056 5 investigate investigate VB cord-010092-uftc8inx 6056 6 the the DT cord-010092-uftc8inx 6056 7 capability capability NN cord-010092-uftc8inx 6056 8 of of IN cord-010092-uftc8inx 6056 9 storage storage NN cord-010092-uftc8inx 6056 10 period period NN cord-010092-uftc8inx 6056 11 for for IN cord-010092-uftc8inx 6056 12 platelet platelet NN cord-010092-uftc8inx 6056 13 units unit NNS cord-010092-uftc8inx 6056 14 , , , cord-010092-uftc8inx 6056 15 from from IN cord-010092-uftc8inx 6056 16 5 5 CD cord-010092-uftc8inx 6056 17 to to TO cord-010092-uftc8inx 6056 18 7 7 CD cord-010092-uftc8inx 6056 19 days day NNS cord-010092-uftc8inx 6056 20 . . . cord-010092-uftc8inx 6057 1 Methods method NNS cord-010092-uftc8inx 6057 2 : : : cord-010092-uftc8inx 6057 3 In in IN cord-010092-uftc8inx 6057 4 this this DT cord-010092-uftc8inx 6057 5 study study NN cord-010092-uftc8inx 6057 6 , , , cord-010092-uftc8inx 6057 7 platelets platelet NNS cord-010092-uftc8inx 6057 8 were be VBD cord-010092-uftc8inx 6057 9 collected collect VBN cord-010092-uftc8inx 6057 10 from from IN cord-010092-uftc8inx 6057 11 11 11 CD cord-010092-uftc8inx 6057 12 normal normal JJ cord-010092-uftc8inx 6057 13 blood blood NN cord-010092-uftc8inx 6057 14 donors donor NNS cord-010092-uftc8inx 6057 15 in in IN cord-010092-uftc8inx 6057 16 the the DT cord-010092-uftc8inx 6057 17 Blood Blood NNP cord-010092-uftc8inx 6057 18 Bank Bank NNP cord-010092-uftc8inx 6057 19 Department Department NNP cord-010092-uftc8inx 6057 20 of of IN cord-010092-uftc8inx 6057 21 General General NNP cord-010092-uftc8inx 6057 22 Hospital Hospital NNP cord-010092-uftc8inx 6057 23 of of IN cord-010092-uftc8inx 6057 24 Patras Patras NNP cord-010092-uftc8inx 6057 25 " " `` cord-010092-uftc8inx 6057 26 Agios Agios NNP cord-010092-uftc8inx 6057 27 Andreas Andreas NNP cord-010092-uftc8inx 6057 28 " " '' cord-010092-uftc8inx 6057 29 . . . cord-010092-uftc8inx 6058 1 A a DT cord-010092-uftc8inx 6058 2 total total NN cord-010092-uftc8inx 6058 3 of of IN cord-010092-uftc8inx 6058 4 450 450 CD cord-010092-uftc8inx 6058 5 AE AE NNP cord-010092-uftc8inx 6058 6 10 10 CD cord-010092-uftc8inx 6058 7 mL mL NNS cord-010092-uftc8inx 6058 8 of of IN cord-010092-uftc8inx 6058 9 whole whole JJ cord-010092-uftc8inx 6058 10 blood blood NN cord-010092-uftc8inx 6058 11 was be VBD cord-010092-uftc8inx 6058 12 drawn draw VBN cord-010092-uftc8inx 6058 13 into into IN cord-010092-uftc8inx 6058 14 triple triple JJ cord-010092-uftc8inx 6058 15 CPD CPD NNP cord-010092-uftc8inx 6058 16 / / SYM cord-010092-uftc8inx 6058 17 SAG SAG NNP cord-010092-uftc8inx 6058 18 - - HYPH cord-010092-uftc8inx 6058 19 M M NNP cord-010092-uftc8inx 6058 20 top top JJ cord-010092-uftc8inx 6058 21 - - HYPH cord-010092-uftc8inx 6058 22 top top NN cord-010092-uftc8inx 6058 23 bags bag NNS cord-010092-uftc8inx 6058 24 blood blood NN cord-010092-uftc8inx 6058 25 container container NN cord-010092-uftc8inx 6058 26 systems system NNS cord-010092-uftc8inx 6058 27 , , , cord-010092-uftc8inx 6058 28 Lmb Lmb NNP cord-010092-uftc8inx 6058 29 Technologie Technologie NNP cord-010092-uftc8inx 6058 30 ( ( -LRB- cord-010092-uftc8inx 6058 31 GmbH GmbH NNP cord-010092-uftc8inx 6058 32 ) ) -RRB- cord-010092-uftc8inx 6058 33 . . . cord-010092-uftc8inx 6059 1 The the DT cord-010092-uftc8inx 6059 2 platelet platelet NN cord-010092-uftc8inx 6059 3 concentrates concentrate VBZ cord-010092-uftc8inx 6059 4 were be VBD cord-010092-uftc8inx 6059 5 prepared prepare VBN cord-010092-uftc8inx 6059 6 by by IN cord-010092-uftc8inx 6059 7 platelet platelet NN cord-010092-uftc8inx 6059 8 rich rich JJ cord-010092-uftc8inx 6059 9 plasma plasma NN cord-010092-uftc8inx 6059 10 ( ( -LRB- cord-010092-uftc8inx 6059 11 PRP prp NN cord-010092-uftc8inx 6059 12 ) ) -RRB- cord-010092-uftc8inx 6059 13 method method NN cord-010092-uftc8inx 6060 1 and and CC cord-010092-uftc8inx 6060 2 then then RB cord-010092-uftc8inx 6060 3 they -PRON- PRP cord-010092-uftc8inx 6060 4 were be VBD cord-010092-uftc8inx 6060 5 placed place VBN cord-010092-uftc8inx 6060 6 in in IN cord-010092-uftc8inx 6060 7 a a DT cord-010092-uftc8inx 6060 8 platelet platelet NN cord-010092-uftc8inx 6060 9 incubator incubator NN cord-010092-uftc8inx 6060 10 with with IN cord-010092-uftc8inx 6060 11 agitator agitator NN cord-010092-uftc8inx 6060 12 ( ( -LRB- cord-010092-uftc8inx 6060 13 Helmer Helmer NNP cord-010092-uftc8inx 6060 14 PC pc NN cord-010092-uftc8inx 6060 15 1200 1200 CD cord-010092-uftc8inx 6060 16 ) ) -RRB- cord-010092-uftc8inx 6060 17 . . . cord-010092-uftc8inx 6061 1 Samples sample NNS cord-010092-uftc8inx 6061 2 were be VBD cord-010092-uftc8inx 6061 3 drawn draw VBN cord-010092-uftc8inx 6061 4 aseptically aseptically RB cord-010092-uftc8inx 6061 5 with with IN cord-010092-uftc8inx 6061 6 a a DT cord-010092-uftc8inx 6061 7 needless needless JJ cord-010092-uftc8inx 6061 8 access access NN cord-010092-uftc8inx 6061 9 coupler coupler NN cord-010092-uftc8inx 6061 10 ( ( -LRB- cord-010092-uftc8inx 6061 11 CAIR CAIR NNP cord-010092-uftc8inx 6061 12 - - HYPH cord-010092-uftc8inx 6061 13 LGL LGL NNP cord-010092-uftc8inx 6061 14 ) ) -RRB- cord-010092-uftc8inx 6061 15 on on IN cord-010092-uftc8inx 6061 16 days day NNS cord-010092-uftc8inx 6061 17 1 1 CD cord-010092-uftc8inx 6061 18 , , , cord-010092-uftc8inx 6061 19 5 5 CD cord-010092-uftc8inx 6061 20 , , , cord-010092-uftc8inx 6061 21 and and CC cord-010092-uftc8inx 6061 22 7 7 CD cord-010092-uftc8inx 6061 23 . . . cord-010092-uftc8inx 6062 1 Platelet platelet NN cord-010092-uftc8inx 6062 2 count count NN cord-010092-uftc8inx 6062 3 was be VBD cord-010092-uftc8inx 6062 4 done do VBN cord-010092-uftc8inx 6062 5 by by IN cord-010092-uftc8inx 6062 6 CEELDYN CEELDYN NNP cord-010092-uftc8inx 6062 7 Ruby Ruby NNP cord-010092-uftc8inx 6063 1 ( ( -LRB- cord-010092-uftc8inx 6063 2 ABBOTT ABBOTT NNP cord-010092-uftc8inx 6063 3 All all DT cord-010092-uftc8inx 6063 4 data datum NNS cord-010092-uftc8inx 6063 5 shown show VBN cord-010092-uftc8inx 6063 6 are be VBP cord-010092-uftc8inx 6063 7 reported report VBN cord-010092-uftc8inx 6063 8 as as IN cord-010092-uftc8inx 6063 9 mean mean JJ cord-010092-uftc8inx 6063 10 AE AE NNP cord-010092-uftc8inx 6063 11 standard standard JJ cord-010092-uftc8inx 6063 12 deviation deviation NN cord-010092-uftc8inx 6063 13 ( ( -LRB- cord-010092-uftc8inx 6063 14 SD sd NN cord-010092-uftc8inx 6063 15 ) ) -RRB- cord-010092-uftc8inx 6063 16 . . . cord-010092-uftc8inx 6064 1 The the DT cord-010092-uftc8inx 6064 2 swirling swirling JJ cord-010092-uftc8inx 6064 3 effect effect NN cord-010092-uftc8inx 6064 4 remained remain VBD cord-010092-uftc8inx 6064 5 positive positive JJ cord-010092-uftc8inx 6064 6 ( ( -LRB- cord-010092-uftc8inx 6064 7 + + CC cord-010092-uftc8inx 6064 8 ) ) -RRB- cord-010092-uftc8inx 6064 9 during during IN cord-010092-uftc8inx 6064 10 the the DT cord-010092-uftc8inx 6064 11 seven seven CD cord-010092-uftc8inx 6064 12 days day NNS cord-010092-uftc8inx 6064 13 storage storage NN cord-010092-uftc8inx 6064 14 period period NN cord-010092-uftc8inx 6064 15 . . . cord-010092-uftc8inx 6065 1 The the DT cord-010092-uftc8inx 6065 2 bacterial bacterial JJ cord-010092-uftc8inx 6065 3 screening screening NN cord-010092-uftc8inx 6065 4 was be VBD cord-010092-uftc8inx 6065 5 found find VBN cord-010092-uftc8inx 6065 6 negative negative JJ cord-010092-uftc8inx 6065 7 . . . cord-010092-uftc8inx 6066 1 Summary Summary NNP cord-010092-uftc8inx 6066 2 / / SYM cord-010092-uftc8inx 6066 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 6066 4 : : : cord-010092-uftc8inx 6067 1 Platelet platelet NN cord-010092-uftc8inx 6067 2 concentration concentration NN cord-010092-uftc8inx 6067 3 in in IN cord-010092-uftc8inx 6067 4 the the DT cord-010092-uftc8inx 6067 5 bag bag NN cord-010092-uftc8inx 6067 6 remained remain VBD cord-010092-uftc8inx 6067 7 constant constant JJ cord-010092-uftc8inx 6067 8 between between IN cord-010092-uftc8inx 6067 9 day day NN cord-010092-uftc8inx 6067 10 5 5 CD cord-010092-uftc8inx 6067 11 and and CC cord-010092-uftc8inx 6067 12 day day NN cord-010092-uftc8inx 6067 13 7 7 CD cord-010092-uftc8inx 6067 14 , , , cord-010092-uftc8inx 6067 15 maintaining maintain VBG cord-010092-uftc8inx 6067 16 platelet platelet NN cord-010092-uftc8inx 6067 17 yield yield NN cord-010092-uftc8inx 6067 18 . . . cord-010092-uftc8inx 6068 1 The the DT cord-010092-uftc8inx 6068 2 decrease decrease NN cord-010092-uftc8inx 6068 3 in in IN cord-010092-uftc8inx 6068 4 glucose glucose NN cord-010092-uftc8inx 6068 5 and and CC cord-010092-uftc8inx 6068 6 increase increase NN cord-010092-uftc8inx 6068 7 in in IN cord-010092-uftc8inx 6068 8 lactate lactate NN cord-010092-uftc8inx 6068 9 , , , cord-010092-uftc8inx 6068 10 along along IN cord-010092-uftc8inx 6068 11 with with IN cord-010092-uftc8inx 6068 12 the the DT cord-010092-uftc8inx 6068 13 decreased decrease VBN cord-010092-uftc8inx 6068 14 pH ph NN cord-010092-uftc8inx 6068 15 , , , cord-010092-uftc8inx 6068 16 show show VBP cord-010092-uftc8inx 6068 17 that that IN cord-010092-uftc8inx 6068 18 the the DT cord-010092-uftc8inx 6068 19 platelets platelet NNS cord-010092-uftc8inx 6068 20 remain remain VBP cord-010092-uftc8inx 6068 21 metabolically metabolically RB cord-010092-uftc8inx 6068 22 active active JJ cord-010092-uftc8inx 6068 23 between between IN cord-010092-uftc8inx 6068 24 days day NNS cord-010092-uftc8inx 6068 25 5 5 CD cord-010092-uftc8inx 6068 26 and and CC cord-010092-uftc8inx 6068 27 7 7 CD cord-010092-uftc8inx 6068 28 of of IN cord-010092-uftc8inx 6068 29 storage storage NN cord-010092-uftc8inx 6068 30 . . . cord-010092-uftc8inx 6069 1 The the DT cord-010092-uftc8inx 6069 2 pH ph NN cord-010092-uftc8inx 6069 3 remained remain VBD cord-010092-uftc8inx 6069 4 well well RB cord-010092-uftc8inx 6069 5 within within IN cord-010092-uftc8inx 6069 6 the the DT cord-010092-uftc8inx 6069 7 acceptable acceptable JJ cord-010092-uftc8inx 6069 8 range range NN cord-010092-uftc8inx 6069 9 . . . cord-010092-uftc8inx 6070 1 No no DT cord-010092-uftc8inx 6070 2 bacterial bacterial JJ cord-010092-uftc8inx 6070 3 contamination contamination NN cord-010092-uftc8inx 6070 4 was be VBD cord-010092-uftc8inx 6070 5 reported report VBN cord-010092-uftc8inx 6070 6 . . . cord-010092-uftc8inx 6071 1 Thus thus RB cord-010092-uftc8inx 6071 2 , , , cord-010092-uftc8inx 6071 3 we -PRON- PRP cord-010092-uftc8inx 6071 4 conclude conclude VBP cord-010092-uftc8inx 6071 5 that that IN cord-010092-uftc8inx 6071 6 platelet platelet NN cord-010092-uftc8inx 6071 7 concentrates concentrate VBZ cord-010092-uftc8inx 6071 8 in in IN cord-010092-uftc8inx 6071 9 these these DT cord-010092-uftc8inx 6071 10 specific specific JJ cord-010092-uftc8inx 6071 11 bags bag NNS cord-010092-uftc8inx 6071 12 may may MD cord-010092-uftc8inx 6071 13 be be VB cord-010092-uftc8inx 6071 14 used use VBN cord-010092-uftc8inx 6071 15 with with IN cord-010092-uftc8inx 6071 16 an an DT cord-010092-uftc8inx 6071 17 extended extended JJ cord-010092-uftc8inx 6071 18 shelf shelf NN cord-010092-uftc8inx 6071 19 life life NN cord-010092-uftc8inx 6071 20 of of IN cord-010092-uftc8inx 6071 21 7 7 CD cord-010092-uftc8inx 6071 22 days day NNS cord-010092-uftc8inx 6071 23 . . . cord-010092-uftc8inx 6072 1 Further further JJ cord-010092-uftc8inx 6072 2 studies study NNS cord-010092-uftc8inx 6072 3 are be VBP cord-010092-uftc8inx 6072 4 needed need VBN cord-010092-uftc8inx 6072 5 with with IN cord-010092-uftc8inx 6072 6 other other JJ cord-010092-uftc8inx 6072 7 platelet platelet NN cord-010092-uftc8inx 6072 8 bags bag NNS cord-010092-uftc8inx 6072 9 to to TO cord-010092-uftc8inx 6072 10 confirm confirm VB cord-010092-uftc8inx 6072 11 our -PRON- PRP$ cord-010092-uftc8inx 6072 12 hypothesis hypothesis NN cord-010092-uftc8inx 6072 13 . . . cord-010092-uftc8inx 6073 1 Abstract Abstract NNP cord-010092-uftc8inx 6073 2 withdrawn withdraw VBN cord-010092-uftc8inx 6073 3 . . . cord-010092-uftc8inx 6074 1 Aims aim VBZ cord-010092-uftc8inx 6074 2 : : : cord-010092-uftc8inx 6074 3 We -PRON- PRP cord-010092-uftc8inx 6074 4 introduce introduce VBP cord-010092-uftc8inx 6074 5 RT RT NNP cord-010092-uftc8inx 6074 6 - - HYPH cord-010092-uftc8inx 6074 7 DC DC NNP cord-010092-uftc8inx 6074 8 as as IN cord-010092-uftc8inx 6074 9 a a DT cord-010092-uftc8inx 6074 10 fast fast JJ cord-010092-uftc8inx 6074 11 , , , cord-010092-uftc8inx 6074 12 robust robust JJ cord-010092-uftc8inx 6074 13 and and CC cord-010092-uftc8inx 6074 14 unbiased unbiased JJ cord-010092-uftc8inx 6074 15 quality quality NN cord-010092-uftc8inx 6074 16 control control NN cord-010092-uftc8inx 6074 17 tool tool NN cord-010092-uftc8inx 6074 18 for for IN cord-010092-uftc8inx 6074 19 PC pc NN cord-010092-uftc8inx 6074 20 , , , cord-010092-uftc8inx 6074 21 RCC RCC NNP cord-010092-uftc8inx 6074 22 and and CC cord-010092-uftc8inx 6074 23 HPSC HPSC NNP cord-010092-uftc8inx 6074 24 . . . cord-010092-uftc8inx 6075 1 Utilizing utilize VBG cord-010092-uftc8inx 6075 2 the the DT cord-010092-uftc8inx 6075 3 interdependency interdependency NN cord-010092-uftc8inx 6075 4 between between IN cord-010092-uftc8inx 6075 5 cell cell NN cord-010092-uftc8inx 6075 6 deformation deformation NN cord-010092-uftc8inx 6075 7 and and CC cord-010092-uftc8inx 6075 8 the the DT cord-010092-uftc8inx 6075 9 molecular molecular JJ cord-010092-uftc8inx 6075 10 state state NN cord-010092-uftc8inx 6075 11 of of IN cord-010092-uftc8inx 6075 12 the the DT cord-010092-uftc8inx 6075 13 cytoskeleton cytoskeleton NN cord-010092-uftc8inx 6075 14 , , , cord-010092-uftc8inx 6075 15 we -PRON- PRP cord-010092-uftc8inx 6075 16 demonstrate demonstrate VBP cord-010092-uftc8inx 6075 17 that that IN cord-010092-uftc8inx 6075 18 RT RT NNP cord-010092-uftc8inx 6075 19 - - HYPH cord-010092-uftc8inx 6075 20 DC DC NNP cord-010092-uftc8inx 6075 21 is be VBZ cord-010092-uftc8inx 6075 22 capable capable JJ cord-010092-uftc8inx 6075 23 to to TO cord-010092-uftc8inx 6075 24 assess assess VB cord-010092-uftc8inx 6075 25 the the DT cord-010092-uftc8inx 6075 26 quality quality NN cord-010092-uftc8inx 6075 27 of of IN cord-010092-uftc8inx 6075 28 blood blood NN cord-010092-uftc8inx 6075 29 products product NNS cord-010092-uftc8inx 6075 30 . . . cord-010092-uftc8inx 6076 1 Methods method NNS cord-010092-uftc8inx 6076 2 : : : cord-010092-uftc8inx 6076 3 By by IN cord-010092-uftc8inx 6076 4 RT RT NNP cord-010092-uftc8inx 6076 5 - - HYPH cord-010092-uftc8inx 6076 6 DC DC NNP cord-010092-uftc8inx 6076 7 we -PRON- PRP cord-010092-uftc8inx 6076 8 assessed assess VBD cord-010092-uftc8inx 6076 9 : : : cord-010092-uftc8inx 6076 10 i i NN cord-010092-uftc8inx 6076 11 ) ) -RRB- cord-010092-uftc8inx 6076 12 platelets platelet NNS cord-010092-uftc8inx 6076 13 after after IN cord-010092-uftc8inx 6076 14 storage storage NN cord-010092-uftc8inx 6076 15 at at IN cord-010092-uftc8inx 6076 16 4 4 CD cord-010092-uftc8inx 6076 17 ° ° NN cord-010092-uftc8inx 6076 18 C c NN cord-010092-uftc8inx 6076 19 or or CC cord-010092-uftc8inx 6076 20 room room NN cord-010092-uftc8inx 6076 21 temperature temperature NN cord-010092-uftc8inx 6076 22 ( ( -LRB- cord-010092-uftc8inx 6076 23 RT RT NNP cord-010092-uftc8inx 6076 24 ) ) -RRB- cord-010092-uftc8inx 6076 25 over over IN cord-010092-uftc8inx 6076 26 10 10 CD cord-010092-uftc8inx 6076 27 days day NNS cord-010092-uftc8inx 6076 28 for for IN cord-010092-uftc8inx 6076 29 4 4 CD cord-010092-uftc8inx 6076 30 apheresis apheresis NN cord-010092-uftc8inx 6076 31 PCs pc NNS cord-010092-uftc8inx 6076 32 in in IN cord-010092-uftc8inx 6076 33 addition addition NN cord-010092-uftc8inx 6076 34 to to IN cord-010092-uftc8inx 6076 35 standard standard NN cord-010092-uftc8inx 6076 36 in in IN cord-010092-uftc8inx 6076 37 vitro vitro FW cord-010092-uftc8inx 6076 38 platelet platelet NN cord-010092-uftc8inx 6076 39 function function NN cord-010092-uftc8inx 6076 40 assays assay NNS cord-010092-uftc8inx 6076 41 ; ; : cord-010092-uftc8inx 6076 42 ii ii LS cord-010092-uftc8inx 6076 43 ) ) -RRB- cord-010092-uftc8inx 6076 44 . . . cord-010092-uftc8inx 6077 1 red red JJ cord-010092-uftc8inx 6077 2 blood blood NN cord-010092-uftc8inx 6077 3 cells cell NNS cord-010092-uftc8inx 6077 4 before before IN cord-010092-uftc8inx 6077 5 and and CC cord-010092-uftc8inx 6077 6 after after IN cord-010092-uftc8inx 6077 7 gamma gamma NN cord-010092-uftc8inx 6077 8 irradiation irradiation NN cord-010092-uftc8inx 6077 9 in in IN cord-010092-uftc8inx 6077 10 addition addition NN cord-010092-uftc8inx 6077 11 to to IN cord-010092-uftc8inx 6077 12 hemolysis hemolysis NN cord-010092-uftc8inx 6077 13 ; ; : cord-010092-uftc8inx 6077 14 and and CC cord-010092-uftc8inx 6077 15 iii iii LS cord-010092-uftc8inx 6077 16 ) ) -RRB- cord-010092-uftc8inx 6077 17 HPSC hpsc NN cord-010092-uftc8inx 6077 18 after after IN cord-010092-uftc8inx 6077 19 cryopreservation cryopreservation NN cord-010092-uftc8inx 6077 20 with with IN cord-010092-uftc8inx 6077 21 5 5 CD cord-010092-uftc8inx 6077 22 % % NN cord-010092-uftc8inx 6077 23 or or CC cord-010092-uftc8inx 6077 24 10 10 CD cord-010092-uftc8inx 6077 25 % % NN cord-010092-uftc8inx 6077 26 DMSO DMSO NNP cord-010092-uftc8inx 6077 27 in in IN cord-010092-uftc8inx 6077 28 addition addition NN cord-010092-uftc8inx 6077 29 to to IN cord-010092-uftc8inx 6077 30 cell cell NN cord-010092-uftc8inx 6077 31 count count NN cord-010092-uftc8inx 6077 32 , , , cord-010092-uftc8inx 6077 33 and and CC cord-010092-uftc8inx 6077 34 in in IN cord-010092-uftc8inx 6077 35 vitro vitro FW cord-010092-uftc8inx 6077 36 viability viability NN cord-010092-uftc8inx 6077 37 . . . cord-010092-uftc8inx 6078 1 In in IN cord-010092-uftc8inx 6078 2 addition addition NN cord-010092-uftc8inx 6078 3 we -PRON- PRP cord-010092-uftc8inx 6078 4 compared compare VBD cord-010092-uftc8inx 6078 5 the the DT cord-010092-uftc8inx 6078 6 regeneration regeneration NN cord-010092-uftc8inx 6078 7 time time NN cord-010092-uftc8inx 6078 8 of of IN cord-010092-uftc8inx 6078 9 patients patient NNS cord-010092-uftc8inx 6078 10 ' ' POS cord-010092-uftc8inx 6078 11 platelets platelet NNS cord-010092-uftc8inx 6078 12 and and CC cord-010092-uftc8inx 6078 13 leukocytes leukocyte NNS cord-010092-uftc8inx 6078 14 after after IN cord-010092-uftc8inx 6078 15 transplantation transplantation NN cord-010092-uftc8inx 6078 16 of of IN cord-010092-uftc8inx 6078 17 HPSC HPSC NNP cord-010092-uftc8inx 6078 18 products product NNS cord-010092-uftc8inx 6078 19 containing contain VBG cord-010092-uftc8inx 6078 20 either either CC cord-010092-uftc8inx 6078 21 5 5 CD cord-010092-uftc8inx 6078 22 % % NN cord-010092-uftc8inx 6078 23 or or CC cord-010092-uftc8inx 6078 24 10 10 CD cord-010092-uftc8inx 6078 25 % % NN cord-010092-uftc8inx 6078 26 DMSO DMSO NNP cord-010092-uftc8inx 6078 27 . . . cord-010092-uftc8inx 6079 1 Results result NNS cord-010092-uftc8inx 6079 2 : : : cord-010092-uftc8inx 6080 1 For for IN cord-010092-uftc8inx 6080 2 PCs pc NNS cord-010092-uftc8inx 6080 3 standard standard JJ cord-010092-uftc8inx 6080 4 quality quality NN cord-010092-uftc8inx 6080 5 assurance assurance NN cord-010092-uftc8inx 6080 6 tests test NNS cord-010092-uftc8inx 6080 7 did do VBD cord-010092-uftc8inx 6080 8 not not RB cord-010092-uftc8inx 6080 9 show show VB cord-010092-uftc8inx 6080 10 a a DT cord-010092-uftc8inx 6080 11 major major JJ cord-010092-uftc8inx 6080 12 difference difference NN cord-010092-uftc8inx 6080 13 between between IN cord-010092-uftc8inx 6080 14 4 4 CD cord-010092-uftc8inx 6080 15 ° ° NN cord-010092-uftc8inx 6080 16 C c NN cord-010092-uftc8inx 6080 17 and and CC cord-010092-uftc8inx 6080 18 room room NN cord-010092-uftc8inx 6080 19 temperature temperature NN cord-010092-uftc8inx 6080 20 storage storage NN cord-010092-uftc8inx 6080 21 while while IN cord-010092-uftc8inx 6080 22 RT RT NNP cord-010092-uftc8inx 6080 23 - - HYPH cord-010092-uftc8inx 6080 24 DC DC NNP cord-010092-uftc8inx 6080 25 showed show VBD cord-010092-uftc8inx 6080 26 a a DT cord-010092-uftc8inx 6080 27 highly highly RB cord-010092-uftc8inx 6080 28 significant significant JJ cord-010092-uftc8inx 6080 29 difference difference NN cord-010092-uftc8inx 6080 30 between between IN cord-010092-uftc8inx 6080 31 both both DT cord-010092-uftc8inx 6080 32 start start NN cord-010092-uftc8inx 6080 33 conditions condition NNS cord-010092-uftc8inx 6080 34 ( ( -LRB- cord-010092-uftc8inx 6080 35 day day NN cord-010092-uftc8inx 6080 36 1 1 CD cord-010092-uftc8inx 6080 37 - - SYM cord-010092-uftc8inx 6080 38 7 7 CD cord-010092-uftc8inx 6080 39 , , , cord-010092-uftc8inx 6080 40 P p NN cord-010092-uftc8inx 6080 41 < < XX cord-010092-uftc8inx 6080 42 0.001 0.001 CD cord-010092-uftc8inx 6080 43 and and CC cord-010092-uftc8inx 6080 44 day day NN cord-010092-uftc8inx 6080 45 10 10 CD cord-010092-uftc8inx 6080 46 , , , cord-010092-uftc8inx 6080 47 P p NN cord-010092-uftc8inx 6080 48 < < XX cord-010092-uftc8inx 6080 49 0.02 0.02 CD cord-010092-uftc8inx 6080 50 ) ) -RRB- cord-010092-uftc8inx 6080 51 . . . cord-010092-uftc8inx 6081 1 For for IN cord-010092-uftc8inx 6081 2 red red JJ cord-010092-uftc8inx 6081 3 cells cell NNS cord-010092-uftc8inx 6081 4 , , , cord-010092-uftc8inx 6081 5 we -PRON- PRP cord-010092-uftc8inx 6081 6 found find VBD cord-010092-uftc8inx 6081 7 by by IN cord-010092-uftc8inx 6081 8 RT RT NNP cord-010092-uftc8inx 6081 9 - - HYPH cord-010092-uftc8inx 6081 10 DC DC NNP cord-010092-uftc8inx 6081 11 no no DT cord-010092-uftc8inx 6081 12 impact impact NN cord-010092-uftc8inx 6081 13 of of IN cord-010092-uftc8inx 6081 14 gamma gamma NN cord-010092-uftc8inx 6081 15 irradiation irradiation NN cord-010092-uftc8inx 6081 16 with with IN cord-010092-uftc8inx 6081 17 30 30 CD cord-010092-uftc8inx 6081 18 Gy Gy NNS cord-010092-uftc8inx 6081 19 over over IN cord-010092-uftc8inx 6081 20 the the DT cord-010092-uftc8inx 6081 21 entire entire JJ cord-010092-uftc8inx 6081 22 storage storage NN cord-010092-uftc8inx 6081 23 period period NN cord-010092-uftc8inx 6081 24 of of IN cord-010092-uftc8inx 6081 25 42 42 CD cord-010092-uftc8inx 6081 26 days day NNS cord-010092-uftc8inx 6081 27 assessing assess VBG cord-010092-uftc8inx 6081 28 3 3 CD cord-010092-uftc8inx 6081 29 different different JJ cord-010092-uftc8inx 6081 30 RCC RCC NNP cord-010092-uftc8inx 6081 31 . . . cord-010092-uftc8inx 6082 1 For for IN cord-010092-uftc8inx 6082 2 HPSC HPSC NNP cord-010092-uftc8inx 6082 3 , , , cord-010092-uftc8inx 6082 4 RT RT NNP cord-010092-uftc8inx 6082 5 - - HYPH cord-010092-uftc8inx 6082 6 DC DC NNP cord-010092-uftc8inx 6082 7 showed show VBD cord-010092-uftc8inx 6082 8 that that IN cord-010092-uftc8inx 6082 9 cryopreservation cryopreservation NN cord-010092-uftc8inx 6082 10 in in IN cord-010092-uftc8inx 6082 11 liquid liquid JJ cord-010092-uftc8inx 6082 12 nitrogen nitrogen NN cord-010092-uftc8inx 6082 13 resulted result VBD cord-010092-uftc8inx 6082 14 in in IN cord-010092-uftc8inx 6082 15 a a DT cord-010092-uftc8inx 6082 16 significant significant JJ cord-010092-uftc8inx 6082 17 increase increase NN cord-010092-uftc8inx 6082 18 in in IN cord-010092-uftc8inx 6082 19 deformation deformation NN cord-010092-uftc8inx 6082 20 ( ( -LRB- cord-010092-uftc8inx 6082 21 0.052 0.052 CD cord-010092-uftc8inx 6082 22 for for IN cord-010092-uftc8inx 6082 23 5 5 CD cord-010092-uftc8inx 6082 24 % % NN cord-010092-uftc8inx 6082 25 DMSO DMSO NNP cord-010092-uftc8inx 6082 26 versus versus IN cord-010092-uftc8inx 6082 27 0.034 0.034 CD cord-010092-uftc8inx 6082 28 for for IN cord-010092-uftc8inx 6082 29 the the DT cord-010092-uftc8inx 6082 30 control control NN cord-010092-uftc8inx 6082 31 without without IN cord-010092-uftc8inx 6082 32 DMSO DMSO NNP cord-010092-uftc8inx 6082 33 ; ; : cord-010092-uftc8inx 6082 34 P p NN cord-010092-uftc8inx 6082 35 < < XX cord-010092-uftc8inx 6082 36 0.00004 0.00004 CD cord-010092-uftc8inx 6082 37 ) ) -RRB- cord-010092-uftc8inx 6082 38 . . . cord-010092-uftc8inx 6083 1 However however RB cord-010092-uftc8inx 6083 2 , , , cord-010092-uftc8inx 6083 3 this this DT cord-010092-uftc8inx 6083 4 did do VBD cord-010092-uftc8inx 6083 5 not not RB cord-010092-uftc8inx 6083 6 differ differ VB cord-010092-uftc8inx 6083 7 to to IN cord-010092-uftc8inx 6083 8 high high JJ cord-010092-uftc8inx 6083 9 extent extent NN cord-010092-uftc8inx 6083 10 whether whether IN cord-010092-uftc8inx 6083 11 5 5 CD cord-010092-uftc8inx 6083 12 % % NN cord-010092-uftc8inx 6083 13 or or CC cord-010092-uftc8inx 6083 14 10 10 CD cord-010092-uftc8inx 6083 15 % % NN cord-010092-uftc8inx 6083 16 DMSO DMSO NNP cord-010092-uftc8inx 6083 17 were be VBD cord-010092-uftc8inx 6083 18 used use VBN cord-010092-uftc8inx 6083 19 for for IN cord-010092-uftc8inx 6083 20 cryopreservation cryopreservation NN cord-010092-uftc8inx 6083 21 ( ( -LRB- cord-010092-uftc8inx 6083 22 0.035 0.035 CD cord-010092-uftc8inx 6083 23 and and CC cord-010092-uftc8inx 6083 24 0.041 0.041 CD cord-010092-uftc8inx 6083 25 , , , cord-010092-uftc8inx 6083 26 respectively respectively RB cord-010092-uftc8inx 6083 27 ; ; : cord-010092-uftc8inx 6083 28 P p NN cord-010092-uftc8inx 6083 29 < < XX cord-010092-uftc8inx 6083 30 0.02 0.02 CD cord-010092-uftc8inx 6083 31 ) ) -RRB- cord-010092-uftc8inx 6083 32 . . . cord-010092-uftc8inx 6084 1 HPSC HPSC NNP cord-010092-uftc8inx 6084 2 viability viability NN cord-010092-uftc8inx 6084 3 was be VBD cord-010092-uftc8inx 6084 4 lower low JJR cord-010092-uftc8inx 6084 5 after after IN cord-010092-uftc8inx 6084 6 cryopreservation cryopreservation NN cord-010092-uftc8inx 6084 7 using use VBG cord-010092-uftc8inx 6084 8 10 10 CD cord-010092-uftc8inx 6084 9 % % NN cord-010092-uftc8inx 6084 10 DMSO DMSO NNP cord-010092-uftc8inx 6084 11 in in IN cord-010092-uftc8inx 6084 12 comparison comparison NN cord-010092-uftc8inx 6084 13 to to IN cord-010092-uftc8inx 6084 14 using use VBG cord-010092-uftc8inx 6084 15 5 5 CD cord-010092-uftc8inx 6084 16 % % NN cord-010092-uftc8inx 6084 17 DMSO DMSO NNP cord-010092-uftc8inx 6084 18 . . . cord-010092-uftc8inx 6085 1 Overall overall RB cord-010092-uftc8inx 6085 2 , , , cord-010092-uftc8inx 6085 3 blood blood NN cord-010092-uftc8inx 6085 4 cell cell NN cord-010092-uftc8inx 6085 5 regeneration regeneration NN cord-010092-uftc8inx 6085 6 is be VBZ cord-010092-uftc8inx 6085 7 comparable comparable JJ cord-010092-uftc8inx 6085 8 between between IN cord-010092-uftc8inx 6085 9 5 5 CD cord-010092-uftc8inx 6085 10 % % NN cord-010092-uftc8inx 6085 11 and and CC cord-010092-uftc8inx 6085 12 10 10 CD cord-010092-uftc8inx 6085 13 % % NN cord-010092-uftc8inx 6085 14 DMSO DMSO NNP cord-010092-uftc8inx 6085 15 . . . cord-010092-uftc8inx 6086 1 Summary Summary NNP cord-010092-uftc8inx 6086 2 / / SYM cord-010092-uftc8inx 6086 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 6086 4 : : : cord-010092-uftc8inx 6087 1 Studying study VBG cord-010092-uftc8inx 6087 2 platelet platelet NN cord-010092-uftc8inx 6087 3 and and CC cord-010092-uftc8inx 6087 4 red red JJ cord-010092-uftc8inx 6087 5 blood blood NN cord-010092-uftc8inx 6087 6 cell cell NN cord-010092-uftc8inx 6087 7 concentrates concentrate VBZ cord-010092-uftc8inx 6087 8 as as RB cord-010092-uftc8inx 6087 9 well well RB cord-010092-uftc8inx 6087 10 as as IN cord-010092-uftc8inx 6087 11 hematopoietic hematopoietic JJ cord-010092-uftc8inx 6087 12 stem stem NN cord-010092-uftc8inx 6087 13 cells cell NNS cord-010092-uftc8inx 6087 14 under under IN cord-010092-uftc8inx 6087 15 different different JJ cord-010092-uftc8inx 6087 16 , , , cord-010092-uftc8inx 6087 17 clinically clinically RB cord-010092-uftc8inx 6087 18 relevant relevant JJ cord-010092-uftc8inx 6087 19 , , , cord-010092-uftc8inx 6087 20 storage storage NN cord-010092-uftc8inx 6087 21 conditions condition NNS cord-010092-uftc8inx 6088 1 our -PRON- PRP$ cord-010092-uftc8inx 6088 2 results result NNS cord-010092-uftc8inx 6088 3 demonstrate demonstrate VBP cord-010092-uftc8inx 6088 4 that that IN cord-010092-uftc8inx 6088 5 intrinsic intrinsic JJ cord-010092-uftc8inx 6088 6 material material NN cord-010092-uftc8inx 6088 7 properties property NNS cord-010092-uftc8inx 6088 8 reveal reveal VBP cord-010092-uftc8inx 6088 9 insights insight NNS cord-010092-uftc8inx 6088 10 into into IN cord-010092-uftc8inx 6088 11 cell cell NN cord-010092-uftc8inx 6088 12 function function NN cord-010092-uftc8inx 6088 13 and and CC cord-010092-uftc8inx 6088 14 allow allow VB cord-010092-uftc8inx 6088 15 to to TO cord-010092-uftc8inx 6088 16 predict predict VB cord-010092-uftc8inx 6088 17 cellular cellular JJ cord-010092-uftc8inx 6088 18 state state NN cord-010092-uftc8inx 6088 19 in in IN cord-010092-uftc8inx 6088 20 a a DT cord-010092-uftc8inx 6088 21 robust robust JJ cord-010092-uftc8inx 6088 22 way way NN cord-010092-uftc8inx 6088 23 and and CC cord-010092-uftc8inx 6088 24 using use VBG cord-010092-uftc8inx 6088 25 small small JJ cord-010092-uftc8inx 6088 26 sample sample NN cord-010092-uftc8inx 6088 27 volumes volume NNS cord-010092-uftc8inx 6088 28 . . . cord-010092-uftc8inx 6089 1 In in IN cord-010092-uftc8inx 6089 2 order order NN cord-010092-uftc8inx 6089 3 to to TO cord-010092-uftc8inx 6089 4 offer offer VB cord-010092-uftc8inx 6089 5 more more JJR cord-010092-uftc8inx 6089 6 flexibility flexibility NN cord-010092-uftc8inx 6089 7 to to IN cord-010092-uftc8inx 6089 8 the the DT cord-010092-uftc8inx 6089 9 production production NN cord-010092-uftc8inx 6089 10 process process NN cord-010092-uftc8inx 6089 11 , , , cord-010092-uftc8inx 6089 12 the the DT cord-010092-uftc8inx 6089 13 storage storage NN cord-010092-uftc8inx 6089 14 of of IN cord-010092-uftc8inx 6089 15 BCs BCs NNP cord-010092-uftc8inx 6089 16 overnight overnight RB cord-010092-uftc8inx 6089 17 ( ( -LRB- cord-010092-uftc8inx 6089 18 16 16 CD cord-010092-uftc8inx 6089 19 h h NN cord-010092-uftc8inx 6089 20 ) ) -RRB- cord-010092-uftc8inx 6089 21 has have VBZ cord-010092-uftc8inx 6089 22 been be VBN cord-010092-uftc8inx 6089 23 validated validate VBN cord-010092-uftc8inx 6089 24 in in IN cord-010092-uftc8inx 6089 25 our -PRON- PRP$ cord-010092-uftc8inx 6089 26 blood blood NN cord-010092-uftc8inx 6089 27 center center NN cord-010092-uftc8inx 6089 28 . . . cord-010092-uftc8inx 6090 1 Aims aim VBZ cord-010092-uftc8inx 6090 2 : : : cord-010092-uftc8inx 6091 1 The the DT cord-010092-uftc8inx 6091 2 aim aim NN cord-010092-uftc8inx 6091 3 of of IN cord-010092-uftc8inx 6091 4 the the DT cord-010092-uftc8inx 6091 5 study study NN cord-010092-uftc8inx 6091 6 was be VBD cord-010092-uftc8inx 6091 7 to to TO cord-010092-uftc8inx 6091 8 assess assess VB cord-010092-uftc8inx 6091 9 the the DT cord-010092-uftc8inx 6091 10 platelet platelet NN cord-010092-uftc8inx 6091 11 quality quality NN cord-010092-uftc8inx 6091 12 in in IN cord-010092-uftc8inx 6091 13 Platelet platelet NN cord-010092-uftc8inx 6091 14 Concentrates concentrate VBZ cord-010092-uftc8inx 6091 15 derived derive VBN cord-010092-uftc8inx 6091 16 from from IN cord-010092-uftc8inx 6091 17 overnight overnight RB cord-010092-uftc8inx 6091 18 stored store VBN cord-010092-uftc8inx 6091 19 Buffy Buffy NNP cord-010092-uftc8inx 6091 20 Coats Coats NNP cord-010092-uftc8inx 6091 21 . . . cord-010092-uftc8inx 6092 1 Methods method NNS cord-010092-uftc8inx 6092 2 : : : cord-010092-uftc8inx 6093 1 Whole whole JJ cord-010092-uftc8inx 6093 2 blood blood NN cord-010092-uftc8inx 6093 3 collected collect VBN cord-010092-uftc8inx 6093 4 at at IN cord-010092-uftc8inx 6093 5 day day NN cord-010092-uftc8inx 6093 6 0 0 NFP cord-010092-uftc8inx 6093 7 was be VBD cord-010092-uftc8inx 6093 8 separated separate VBN cord-010092-uftc8inx 6093 9 into into IN cord-010092-uftc8inx 6093 10 plasma plasma NN cord-010092-uftc8inx 6093 11 , , , cord-010092-uftc8inx 6093 12 BC BC NNP cord-010092-uftc8inx 6093 13 and and CC cord-010092-uftc8inx 6093 14 Red Red NNP cord-010092-uftc8inx 6093 15 Cell Cell NNP cord-010092-uftc8inx 6093 16 Concentrates concentrate VBZ cord-010092-uftc8inx 6093 17 either either CC cord-010092-uftc8inx 6093 18 at at IN cord-010092-uftc8inx 6093 19 day day NN cord-010092-uftc8inx 6093 20 0 0 CD cord-010092-uftc8inx 6093 21 or or CC cord-010092-uftc8inx 6093 22 at at IN cord-010092-uftc8inx 6093 23 day day NN cord-010092-uftc8inx 6093 24 1 1 CD cord-010092-uftc8inx 6093 25 . . . cord-010092-uftc8inx 6094 1 BCs BCs NNP cord-010092-uftc8inx 6094 2 were be VBD cord-010092-uftc8inx 6094 3 then then RB cord-010092-uftc8inx 6094 4 stored store VBN cord-010092-uftc8inx 6094 5 until until IN cord-010092-uftc8inx 6094 6 the the DT cord-010092-uftc8inx 6094 7 pooling pooling NN cord-010092-uftc8inx 6094 8 step step NN cord-010092-uftc8inx 6094 9 at at IN cord-010092-uftc8inx 6094 10 20 20 CD cord-010092-uftc8inx 6094 11 ° ° NN cord-010092-uftc8inx 6094 12 C c NN cord-010092-uftc8inx 6094 13 without without IN cord-010092-uftc8inx 6094 14 agitation agitation NN cord-010092-uftc8inx 6094 15 and and CC cord-010092-uftc8inx 6094 16 PCs pc NNS cord-010092-uftc8inx 6094 17 were be VBD cord-010092-uftc8inx 6094 18 prepared prepare VBN cord-010092-uftc8inx 6094 19 at at IN cord-010092-uftc8inx 6094 20 day day NN cord-010092-uftc8inx 6094 21 1 1 CD cord-010092-uftc8inx 6094 22 by by IN cord-010092-uftc8inx 6094 23 pooling pool VBG cord-010092-uftc8inx 6094 24 5 5 CD cord-010092-uftc8inx 6094 25 isogroup isogroup NNP cord-010092-uftc8inx 6094 26 BCs BCs NNP cord-010092-uftc8inx 6094 27 . . . cord-010092-uftc8inx 6095 1 Seven seven CD cord-010092-uftc8inx 6095 2 " " `` cord-010092-uftc8inx 6095 3 16 16 CD cord-010092-uftc8inx 6095 4 h h NN cord-010092-uftc8inx 6095 5 - - HYPH cord-010092-uftc8inx 6095 6 PCs pc NNS cord-010092-uftc8inx 6095 7 " " '' cord-010092-uftc8inx 6095 8 were be VBD cord-010092-uftc8inx 6095 9 prepared prepare VBN cord-010092-uftc8inx 6095 10 from from IN cord-010092-uftc8inx 6095 11 BCs BCs NNP cord-010092-uftc8inx 6095 12 stored store VBD cord-010092-uftc8inx 6095 13 for for IN cord-010092-uftc8inx 6095 14 16 16 CD cord-010092-uftc8inx 6095 15 h h NN cord-010092-uftc8inx 6095 16 ( ( -LRB- cord-010092-uftc8inx 6095 17 whole whole JJ cord-010092-uftc8inx 6095 18 blood blood NN cord-010092-uftc8inx 6095 19 separation separation NN cord-010092-uftc8inx 6095 20 at at IN cord-010092-uftc8inx 6095 21 day day NN cord-010092-uftc8inx 6095 22 0 0 CD cord-010092-uftc8inx 6095 23 ) ) -RRB- cord-010092-uftc8inx 6095 24 and and CC cord-010092-uftc8inx 6095 25 six six CD cord-010092-uftc8inx 6095 26 " " `` cord-010092-uftc8inx 6095 27 90 90 CD cord-010092-uftc8inx 6095 28 min min NN cord-010092-uftc8inx 6095 29 - - HYPH cord-010092-uftc8inx 6095 30 PCs pc NNS cord-010092-uftc8inx 6095 31 " " '' cord-010092-uftc8inx 6095 32 from from IN cord-010092-uftc8inx 6095 33 BCs BCs NNP cord-010092-uftc8inx 6095 34 stored store VBD cord-010092-uftc8inx 6095 35 for for IN cord-010092-uftc8inx 6095 36 90 90 CD cord-010092-uftc8inx 6095 37 min min NN cord-010092-uftc8inx 6095 38 ( ( -LRB- cord-010092-uftc8inx 6095 39 whole whole JJ cord-010092-uftc8inx 6095 40 blood blood NN cord-010092-uftc8inx 6095 41 separation separation NN cord-010092-uftc8inx 6095 42 at at IN cord-010092-uftc8inx 6095 43 day day NN cord-010092-uftc8inx 6095 44 1 1 CD cord-010092-uftc8inx 6095 45 ) ) -RRB- cord-010092-uftc8inx 6095 46 . . . cord-010092-uftc8inx 6096 1 Standard standard JJ cord-010092-uftc8inx 6096 2 quality quality NN cord-010092-uftc8inx 6096 3 control control NN cord-010092-uftc8inx 6096 4 measurements measurement NNS cord-010092-uftc8inx 6096 5 were be VBD cord-010092-uftc8inx 6096 6 performed perform VBN cord-010092-uftc8inx 6096 7 during during IN cord-010092-uftc8inx 6096 8 the the DT cord-010092-uftc8inx 6096 9 process process NN cord-010092-uftc8inx 6096 10 and and CC cord-010092-uftc8inx 6096 11 the the DT cord-010092-uftc8inx 6096 12 storage storage NN cord-010092-uftc8inx 6096 13 . . . cord-010092-uftc8inx 6097 1 In in IN cord-010092-uftc8inx 6097 2 addition addition NN cord-010092-uftc8inx 6097 3 , , , cord-010092-uftc8inx 6097 4 the the DT cord-010092-uftc8inx 6097 5 quality quality NN cord-010092-uftc8inx 6097 6 of of IN cord-010092-uftc8inx 6097 7 the the DT cord-010092-uftc8inx 6097 8 platelets platelet NNS cord-010092-uftc8inx 6097 9 into into IN cord-010092-uftc8inx 6097 10 the the DT cord-010092-uftc8inx 6097 11 prepared prepared JJ cord-010092-uftc8inx 6097 12 PCs pc NNS cord-010092-uftc8inx 6097 13 was be VBD cord-010092-uftc8inx 6097 14 assessed assess VBN cord-010092-uftc8inx 6097 15 throughout throughout IN cord-010092-uftc8inx 6097 16 the the DT cord-010092-uftc8inx 6097 17 period period NN cord-010092-uftc8inx 6097 18 of of IN cord-010092-uftc8inx 6097 19 storage storage NN cord-010092-uftc8inx 6097 20 by by IN cord-010092-uftc8inx 6097 21 measuring measure VBG cord-010092-uftc8inx 6097 22 the the DT cord-010092-uftc8inx 6097 23 hypotonic hypotonic JJ cord-010092-uftc8inx 6097 24 shock shock NN cord-010092-uftc8inx 6097 25 response response NN cord-010092-uftc8inx 6097 26 ( ( -LRB- cord-010092-uftc8inx 6097 27 HSR HSR NNP cord-010092-uftc8inx 6097 28 ) ) -RRB- cord-010092-uftc8inx 6097 29 and and CC cord-010092-uftc8inx 6097 30 by by IN cord-010092-uftc8inx 6097 31 measuring measure VBG cord-010092-uftc8inx 6097 32 by by IN cord-010092-uftc8inx 6097 33 flow flow NN cord-010092-uftc8inx 6097 34 cytometry cytometry NN cord-010092-uftc8inx 6097 35 the the DT cord-010092-uftc8inx 6097 36 proportions proportion NNS cord-010092-uftc8inx 6097 37 of of IN cord-010092-uftc8inx 6097 38 platelets platelet NNS cord-010092-uftc8inx 6097 39 in in IN cord-010092-uftc8inx 6097 40 apoptosis apoptosis NN cord-010092-uftc8inx 6097 41 ( ( -LRB- cord-010092-uftc8inx 6097 42 marked mark VBN cord-010092-uftc8inx 6097 43 with with IN cord-010092-uftc8inx 6097 44 Annexin Annexin NNP cord-010092-uftc8inx 6097 45 V V NNP cord-010092-uftc8inx 6097 46 ) ) -RRB- cord-010092-uftc8inx 6097 47 , , , cord-010092-uftc8inx 6097 48 of of IN cord-010092-uftc8inx 6097 49 functional functional JJ cord-010092-uftc8inx 6097 50 platelets platelet NNS cord-010092-uftc8inx 6097 51 ( ( -LRB- cord-010092-uftc8inx 6097 52 marked mark VBN cord-010092-uftc8inx 6097 53 with with IN cord-010092-uftc8inx 6097 54 CD42 CD42 NNP cord-010092-uftc8inx 6097 55 ) ) -RRB- cord-010092-uftc8inx 6097 56 and and CC cord-010092-uftc8inx 6097 57 of of IN cord-010092-uftc8inx 6097 58 activated activate VBN cord-010092-uftc8inx 6097 59 platelets platelet NNS cord-010092-uftc8inx 6097 60 ( ( -LRB- cord-010092-uftc8inx 6097 61 marked mark VBN cord-010092-uftc8inx 6097 62 with with IN cord-010092-uftc8inx 6097 63 CD62 CD62 NNP cord-010092-uftc8inx 6098 1 The the DT cord-010092-uftc8inx 6098 2 changes change NNS cord-010092-uftc8inx 6098 3 observed observe VBD cord-010092-uftc8inx 6098 4 during during IN cord-010092-uftc8inx 6098 5 the the DT cord-010092-uftc8inx 6098 6 8-h 8-h CD cord-010092-uftc8inx 6098 7 storage storage NN cord-010092-uftc8inx 6098 8 period period NN cord-010092-uftc8inx 6098 9 appear appear VBP cord-010092-uftc8inx 6098 10 to to TO cord-010092-uftc8inx 6098 11 be be VB cord-010092-uftc8inx 6098 12 limited limited JJ cord-010092-uftc8inx 6098 13 and and CC cord-010092-uftc8inx 6098 14 compatible compatible JJ cord-010092-uftc8inx 6098 15 with with IN cord-010092-uftc8inx 6098 16 a a DT cord-010092-uftc8inx 6098 17 further further JJ cord-010092-uftc8inx 6098 18 PR pr NN cord-010092-uftc8inx 6098 19 process process NN cord-010092-uftc8inx 6098 20 using use VBG cord-010092-uftc8inx 6098 21 a a DT cord-010092-uftc8inx 6098 22 photochemical photochemical JJ cord-010092-uftc8inx 6098 23 treatment treatment NN cord-010092-uftc8inx 6098 24 ( ( -LRB- cord-010092-uftc8inx 6098 25 amotosalen amotosalen NNP cord-010092-uftc8inx 6098 26 and and CC cord-010092-uftc8inx 6098 27 UVA UVA NNP cord-010092-uftc8inx 6098 28 ) ) -RRB- cord-010092-uftc8inx 6098 29 with with IN cord-010092-uftc8inx 6098 30 INTERCEPT INTERCEPT NNP cord-010092-uftc8inx 6098 31 . . . cord-010092-uftc8inx 6099 1 Summary Summary NNP cord-010092-uftc8inx 6099 2 / / SYM cord-010092-uftc8inx 6099 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 6099 4 : : : cord-010092-uftc8inx 6100 1 Leukocyte Leukocyte NNP cord-010092-uftc8inx 6100 2 - - HYPH cord-010092-uftc8inx 6100 3 depleted deplete VBN cord-010092-uftc8inx 6100 4 " " `` cord-010092-uftc8inx 6100 5 double double JJ cord-010092-uftc8inx 6100 6 dose dose NN cord-010092-uftc8inx 6100 7 " " `` cord-010092-uftc8inx 6100 8 buffy buffy NNP cord-010092-uftc8inx 6100 9 coat coat NN cord-010092-uftc8inx 6100 10 platelets platelet NNS cord-010092-uftc8inx 6100 11 with with IN cord-010092-uftc8inx 6100 12 a a DT cord-010092-uftc8inx 6100 13 high high JJ cord-010092-uftc8inx 6100 14 platelet platelet NN cord-010092-uftc8inx 6100 15 content content NN cord-010092-uftc8inx 6100 16 and and CC cord-010092-uftc8inx 6100 17 ready ready JJ cord-010092-uftc8inx 6100 18 for for IN cord-010092-uftc8inx 6100 19 pathogen pathogen NN cord-010092-uftc8inx 6100 20 reduction reduction NN cord-010092-uftc8inx 6100 21 can can MD cord-010092-uftc8inx 6100 22 be be VB cord-010092-uftc8inx 6100 23 obtained obtain VBN cord-010092-uftc8inx 6100 24 with with IN cord-010092-uftc8inx 6100 25 the the DT cord-010092-uftc8inx 6100 26 IPP IPP NNP cord-010092-uftc8inx 6100 27 pooling pooling NN cord-010092-uftc8inx 6100 28 and and CC cord-010092-uftc8inx 6100 29 leukodepletion leukodepletion NN cord-010092-uftc8inx 6100 30 set set VBN cord-010092-uftc8inx 6100 31 developed develop VBN cord-010092-uftc8inx 6100 32 by by IN cord-010092-uftc8inx 6100 33 Kansuk Kansuk NNP cord-010092-uftc8inx 6100 34 . . . cord-010092-uftc8inx 6101 1 A a DT cord-010092-uftc8inx 6101 2 storage storage NN cord-010092-uftc8inx 6101 3 period period NN cord-010092-uftc8inx 6101 4 of of IN cord-010092-uftc8inx 6101 5 8 8 CD cord-010092-uftc8inx 6101 6 h h NN cord-010092-uftc8inx 6101 7 before before IN cord-010092-uftc8inx 6101 8 applying apply VBG cord-010092-uftc8inx 6101 9 the the DT cord-010092-uftc8inx 6101 10 photochemical photochemical JJ cord-010092-uftc8inx 6101 11 treatment treatment NN cord-010092-uftc8inx 6101 12 is be VBZ cord-010092-uftc8inx 6101 13 feasible feasible JJ cord-010092-uftc8inx 6101 14 without without IN cord-010092-uftc8inx 6101 15 significantly significantly RB cord-010092-uftc8inx 6101 16 altering alter VBG cord-010092-uftc8inx 6101 17 the the DT cord-010092-uftc8inx 6101 18 biological biological JJ cord-010092-uftc8inx 6101 19 quality quality NN cord-010092-uftc8inx 6101 20 of of IN cord-010092-uftc8inx 6101 21 platelets platelet NNS cord-010092-uftc8inx 6101 22 . . . cord-010092-uftc8inx 6102 1 Methods method NNS cord-010092-uftc8inx 6102 2 : : : cord-010092-uftc8inx 6102 3 32 32 CD cord-010092-uftc8inx 6102 4 DD DD NNP cord-010092-uftc8inx 6102 5 - - HYPH cord-010092-uftc8inx 6102 6 BC BC NNP cord-010092-uftc8inx 6102 7 - - HYPH cord-010092-uftc8inx 6102 8 PC PC NNP cord-010092-uftc8inx 6102 9 were be VBD cord-010092-uftc8inx 6102 10 prepared prepare VBN cord-010092-uftc8inx 6102 11 with with IN cord-010092-uftc8inx 6102 12 8 8 CD cord-010092-uftc8inx 6102 13 BC BC NNP cord-010092-uftc8inx 6102 14 and and CC cord-010092-uftc8inx 6102 15 280 280 CD cord-010092-uftc8inx 6102 16 ml ml NNS cord-010092-uftc8inx 6102 17 of of IN cord-010092-uftc8inx 6102 18 PAS pas NN cord-010092-uftc8inx 6102 19 ( ( -LRB- cord-010092-uftc8inx 6102 20 InterSol InterSol NNP cord-010092-uftc8inx 6102 21 , , , cord-010092-uftc8inx 6102 22 Fresenius Fresenius NNP cord-010092-uftc8inx 6102 23 Kabi Kabi NNP cord-010092-uftc8inx 6102 24 ( ( -LRB- cord-010092-uftc8inx 6102 25 Germany Germany NNP cord-010092-uftc8inx 6102 26 ) ) -RRB- cord-010092-uftc8inx 6102 27 are be VBP cord-010092-uftc8inx 6102 28 sterile sterile JJ cord-010092-uftc8inx 6102 29 docked dock VBN cord-010092-uftc8inx 6102 30 to to IN cord-010092-uftc8inx 6102 31 the the DT cord-010092-uftc8inx 6102 32 Octopus Octopus NNP cord-010092-uftc8inx 6102 33 harness harness NN cord-010092-uftc8inx 6102 34 and and CC cord-010092-uftc8inx 6102 35 combined combine VBD cord-010092-uftc8inx 6102 36 into into IN cord-010092-uftc8inx 6102 37 a a DT cord-010092-uftc8inx 6102 38 600 600 CD cord-010092-uftc8inx 6102 39 ml ml NN cord-010092-uftc8inx 6102 40 pooling pooling NN cord-010092-uftc8inx 6102 41 bag bag NN cord-010092-uftc8inx 6102 42 . . . cord-010092-uftc8inx 6103 1 The the DT cord-010092-uftc8inx 6103 2 pool pool NN cord-010092-uftc8inx 6103 3 is be VBZ cord-010092-uftc8inx 6103 4 centrifuged centrifuge VBN cord-010092-uftc8inx 6103 5 and and CC cord-010092-uftc8inx 6103 6 the the DT cord-010092-uftc8inx 6103 7 PC pc NN cord-010092-uftc8inx 6103 8 supernatant supernatant NN cord-010092-uftc8inx 6103 9 expressed express VBN cord-010092-uftc8inx 6103 10 through through IN cord-010092-uftc8inx 6103 11 a a DT cord-010092-uftc8inx 6103 12 Bioflex Bioflex NNP cord-010092-uftc8inx 6103 13 CS CS NNP cord-010092-uftc8inx 6103 14 leukodepletion leukodepletion NN cord-010092-uftc8inx 6103 15 filter filter NN cord-010092-uftc8inx 6103 16 into into IN cord-010092-uftc8inx 6103 17 a a DT cord-010092-uftc8inx 6103 18 temporary temporary JJ cord-010092-uftc8inx 6103 19 platelet platelet NN cord-010092-uftc8inx 6103 20 storage storage NN cord-010092-uftc8inx 6103 21 container container NN cord-010092-uftc8inx 6103 22 . . . cord-010092-uftc8inx 6104 1 The the DT cord-010092-uftc8inx 6104 2 obtained obtain VBN cord-010092-uftc8inx 6104 3 DD DD NNP cord-010092-uftc8inx 6104 4 - - HYPH cord-010092-uftc8inx 6104 5 BC BC NNP cord-010092-uftc8inx 6104 6 - - HYPH cord-010092-uftc8inx 6104 7 PC PC NNP cord-010092-uftc8inx 6104 8 were be VBD cord-010092-uftc8inx 6104 9 tested test VBN cord-010092-uftc8inx 6104 10 within within IN cord-010092-uftc8inx 6104 11 1 1 CD cord-010092-uftc8inx 6104 12 h h NN cord-010092-uftc8inx 6104 13 of of IN cord-010092-uftc8inx 6104 14 preparation preparation NN cord-010092-uftc8inx 6104 15 and and CC cord-010092-uftc8inx 6104 16 after after IN cord-010092-uftc8inx 6104 17 storage storage NN cord-010092-uftc8inx 6104 18 for for IN cord-010092-uftc8inx 6104 19 8 8 CD cord-010092-uftc8inx 6104 20 h h NN cord-010092-uftc8inx 6104 21 in in IN cord-010092-uftc8inx 6104 22 the the DT cord-010092-uftc8inx 6104 23 platelet platelet NN cord-010092-uftc8inx 6104 24 storage storage NN cord-010092-uftc8inx 6104 25 container container NN cord-010092-uftc8inx 6104 26 for for IN cord-010092-uftc8inx 6104 27 volume volume NN cord-010092-uftc8inx 6104 28 , , , cord-010092-uftc8inx 6104 29 platelet platelet NN cord-010092-uftc8inx 6104 30 content content NN cord-010092-uftc8inx 6104 31 , , , cord-010092-uftc8inx 6104 32 residual residual JJ cord-010092-uftc8inx 6104 33 leukocytes leukocyte NNS cord-010092-uftc8inx 6104 34 ( ( -LRB- cord-010092-uftc8inx 6104 35 WBC WBC NNP cord-010092-uftc8inx 6104 36 ) ) -RRB- cord-010092-uftc8inx 6104 37 , , , cord-010092-uftc8inx 6104 38 plasma plasma NN cord-010092-uftc8inx 6104 39 ratio ratio NN cord-010092-uftc8inx 6104 40 and and CC cord-010092-uftc8inx 6104 41 biological biological JJ cord-010092-uftc8inx 6104 42 parameters parameter NNS cord-010092-uftc8inx 6104 43 , , , cord-010092-uftc8inx 6104 44 pH ph NN cord-010092-uftc8inx 6104 45 , , , cord-010092-uftc8inx 6104 46 pO pO NNP cord-010092-uftc8inx 6104 47 2 2 CD cord-010092-uftc8inx 6104 48 , , , cord-010092-uftc8inx 6104 49 pCO pco CD cord-010092-uftc8inx 6104 50 2 2 CD cord-010092-uftc8inx 6104 51 , , , cord-010092-uftc8inx 6104 52 glucose glucose NN cord-010092-uftc8inx 6104 53 , , , cord-010092-uftc8inx 6104 54 lactate lactate NN cord-010092-uftc8inx 6104 55 , , , cord-010092-uftc8inx 6104 56 MPV MPV NNP cord-010092-uftc8inx 6104 57 , , , cord-010092-uftc8inx 6104 58 LDH LDH NNP cord-010092-uftc8inx 6104 59 , , , cord-010092-uftc8inx 6104 60 p p NN cord-010092-uftc8inx 6104 61 - - HYPH cord-010092-uftc8inx 6104 62 selectin selectin NN cord-010092-uftc8inx 6104 63 and and CC cord-010092-uftc8inx 6104 64 swirling swirl VBG cord-010092-uftc8inx 6104 65 . . . cord-010092-uftc8inx 6105 1 Results result NNS cord-010092-uftc8inx 6105 2 : : : cord-010092-uftc8inx 6106 1 The the DT cord-010092-uftc8inx 6106 2 platelet platelet NN cord-010092-uftc8inx 6106 3 content content NN cord-010092-uftc8inx 6106 4 of of IN cord-010092-uftc8inx 6106 5 DD DD NNP cord-010092-uftc8inx 6106 6 - - HYPH cord-010092-uftc8inx 6106 7 BC BC NNP cord-010092-uftc8inx 6106 8 - - HYPH cord-010092-uftc8inx 6106 9 PC PC NNP cord-010092-uftc8inx 6106 10 ( ( -LRB- cord-010092-uftc8inx 6106 11 n n NN cord-010092-uftc8inx 6106 12 = = SYM cord-010092-uftc8inx 6106 13 32 32 CD cord-010092-uftc8inx 6106 14 ) ) -RRB- cord-010092-uftc8inx 6106 15 was be VBD cord-010092-uftc8inx 6106 16 on on IN cord-010092-uftc8inx 6106 17 average average JJ cord-010092-uftc8inx 6106 18 6.9 6.9 CD cord-010092-uftc8inx 6106 19 AE AE NNP cord-010092-uftc8inx 6106 20 0.3.10 0.3.10 CD cord-010092-uftc8inx 6106 21 11 11 CD cord-010092-uftc8inx 6106 22 in in IN cord-010092-uftc8inx 6106 23 a a DT cord-010092-uftc8inx 6106 24 volume volume NN cord-010092-uftc8inx 6106 25 of of IN cord-010092-uftc8inx 6106 26 393 393 CD cord-010092-uftc8inx 6106 27 AE AE NNP cord-010092-uftc8inx 6106 28 6 6 CD cord-010092-uftc8inx 6106 29 ml ml NN cord-010092-uftc8inx 6106 30 . . . cord-010092-uftc8inx 6107 1 The the DT cord-010092-uftc8inx 6107 2 mean mean NN cord-010092-uftc8inx 6107 3 of of IN cord-010092-uftc8inx 6107 4 plasma plasma NN cord-010092-uftc8inx 6107 5 ratio ratio NN cord-010092-uftc8inx 6107 6 was be VBD cord-010092-uftc8inx 6107 7 42 42 CD cord-010092-uftc8inx 6107 8 % % NN cord-010092-uftc8inx 6107 9 [ [ -LRB- cord-010092-uftc8inx 6107 10 min min NN cord-010092-uftc8inx 6107 11 : : : cord-010092-uftc8inx 6107 12 39.3max 39.3max CD cord-010092-uftc8inx 6107 13 : : : cord-010092-uftc8inx 6107 14 43.9 43.9 CD cord-010092-uftc8inx 6107 15 ] ] -RRB- cord-010092-uftc8inx 6107 16 . . . cord-010092-uftc8inx 6108 1 All all DT cord-010092-uftc8inx 6108 2 PC pc NN cord-010092-uftc8inx 6108 3 contain contain VBP cord-010092-uftc8inx 6108 4 < < NNP cord-010092-uftc8inx 6108 5 1.10 1.10 CD cord-010092-uftc8inx 6108 6 6 6 CD cord-010092-uftc8inx 6108 7 WBC WBC NNP cord-010092-uftc8inx 6108 8 [ [ -LRB- cord-010092-uftc8inx 6108 9 min min NN cord-010092-uftc8inx 6108 10 : : : cord-010092-uftc8inx 6108 11 < < XX cord-010092-uftc8inx 6108 12 LQ LQ NNP cord-010092-uftc8inx 6108 13 ; ; : cord-010092-uftc8inx 6108 14 max max NNP cord-010092-uftc8inx 6108 15 : : : cord-010092-uftc8inx 6108 16 0.38 0.38 CD cord-010092-uftc8inx 6108 17 ] ] -RRB- cord-010092-uftc8inx 6108 18 . . . cord-010092-uftc8inx 6109 1 pO po NN cord-010092-uftc8inx 6109 2 2 2 CD cord-010092-uftc8inx 6109 3 decreased decrease VBD cord-010092-uftc8inx 6109 4 from from IN cord-010092-uftc8inx 6109 5 166 166 CD cord-010092-uftc8inx 6109 6 AE AE NNP cord-010092-uftc8inx 6109 7 12 12 CD cord-010092-uftc8inx 6109 8 mmHg mmHg NNS cord-010092-uftc8inx 6109 9 after after IN cord-010092-uftc8inx 6109 10 separation separation NN cord-010092-uftc8inx 6109 11 ( ( -LRB- cord-010092-uftc8inx 6109 12 1 1 CD cord-010092-uftc8inx 6109 13 h h NN cord-010092-uftc8inx 6109 14 ) ) -RRB- cord-010092-uftc8inx 6109 15 to to IN cord-010092-uftc8inx 6109 16 44 44 CD cord-010092-uftc8inx 6109 17 AE AE NNP cord-010092-uftc8inx 6109 18 18 18 CD cord-010092-uftc8inx 6109 19 mmHg mmHg NNS cord-010092-uftc8inx 6109 20 after after IN cord-010092-uftc8inx 6109 21 8 8 CD cord-010092-uftc8inx 6109 22 h h NN cord-010092-uftc8inx 6109 23 , , , cord-010092-uftc8inx 6109 24 pH pH NNP cord-010092-uftc8inx 6109 25 ( ( -LRB- cord-010092-uftc8inx 6109 26 +22 +22 IN cord-010092-uftc8inx 6109 27 ° ° NNP cord-010092-uftc8inx 6109 28 C C NNP cord-010092-uftc8inx 6109 29 ) ) -RRB- cord-010092-uftc8inx 6109 30 and and CC cord-010092-uftc8inx 6109 31 pCO pco CD cord-010092-uftc8inx 6109 32 2 2 CD cord-010092-uftc8inx 6109 33 was be VBD cord-010092-uftc8inx 6109 34 stable stable JJ cord-010092-uftc8inx 6109 35 during during IN cord-010092-uftc8inx 6109 36 the the DT cord-010092-uftc8inx 6109 37 same same JJ cord-010092-uftc8inx 6109 38 time time NN cord-010092-uftc8inx 6109 39 period period NN cord-010092-uftc8inx 6109 40 . . . cord-010092-uftc8inx 6110 1 Glucose glucose NN cord-010092-uftc8inx 6110 2 decreased decrease VBD cord-010092-uftc8inx 6110 3 from from IN cord-010092-uftc8inx 6110 4 9.0 9.0 CD cord-010092-uftc8inx 6110 5 AE AE NNP cord-010092-uftc8inx 6110 6 0.3 0.3 CD cord-010092-uftc8inx 6110 7 mmol mmol JJ cord-010092-uftc8inx 6110 8 / / SYM cord-010092-uftc8inx 6110 9 l l NN cord-010092-uftc8inx 6110 10 ( ( -LRB- cord-010092-uftc8inx 6110 11 1 1 CD cord-010092-uftc8inx 6110 12 h h NN cord-010092-uftc8inx 6110 13 ) ) -RRB- cord-010092-uftc8inx 6110 14 to to IN cord-010092-uftc8inx 6110 15 8.7 8.7 CD cord-010092-uftc8inx 6110 16 AE AE NNP cord-010092-uftc8inx 6110 17 0.3 0.3 CD cord-010092-uftc8inx 6110 18 mmol mmol NN cord-010092-uftc8inx 6110 19 / / SYM cord-010092-uftc8inx 6110 20 l l NN cord-010092-uftc8inx 6110 21 ( ( -LRB- cord-010092-uftc8inx 6110 22 8 8 CD cord-010092-uftc8inx 6110 23 h h NN cord-010092-uftc8inx 6110 24 ) ) -RRB- cord-010092-uftc8inx 6110 25 while while IN cord-010092-uftc8inx 6110 26 Lactate Lactate NNP cord-010092-uftc8inx 6110 27 increased increase VBD cord-010092-uftc8inx 6110 28 from from IN cord-010092-uftc8inx 6110 29 6.07 6.07 CD cord-010092-uftc8inx 6110 30 AE AE NNP cord-010092-uftc8inx 6110 31 0.46 0.46 CD cord-010092-uftc8inx 6110 32 mmol mmol NNP cord-010092-uftc8inx 6110 33 / / SYM cord-010092-uftc8inx 6110 34 l l NN cord-010092-uftc8inx 6110 35 ( ( -LRB- cord-010092-uftc8inx 6110 36 1 1 CD cord-010092-uftc8inx 6110 37 h h NN cord-010092-uftc8inx 6110 38 ) ) -RRB- cord-010092-uftc8inx 6110 39 to to IN cord-010092-uftc8inx 6110 40 6.57 6.57 CD cord-010092-uftc8inx 6110 41 AE AE NNP cord-010092-uftc8inx 6110 42 0.54 0.54 CD cord-010092-uftc8inx 6110 43 mmol mmol NNP cord-010092-uftc8inx 6110 44 / / SYM cord-010092-uftc8inx 6110 45 l l NN cord-010092-uftc8inx 6110 46 ( ( -LRB- cord-010092-uftc8inx 6110 47 8 8 CD cord-010092-uftc8inx 6110 48 h h NN cord-010092-uftc8inx 6110 49 ) ) -RRB- cord-010092-uftc8inx 6110 50 . . . cord-010092-uftc8inx 6111 1 The the DT cord-010092-uftc8inx 6111 2 VPM VPM NNP cord-010092-uftc8inx 6111 3 was be VBD cord-010092-uftc8inx 6111 4 stable stable JJ cord-010092-uftc8inx 6111 5 with with IN cord-010092-uftc8inx 6111 6 7.6 7.6 CD cord-010092-uftc8inx 6111 7 AE AE NNP cord-010092-uftc8inx 6111 8 0.2 0.2 CD cord-010092-uftc8inx 6111 9 at at IN cord-010092-uftc8inx 6111 10 1 1 CD cord-010092-uftc8inx 6111 11 h h NN cord-010092-uftc8inx 6111 12 and and CC cord-010092-uftc8inx 6112 1 8 8 CD cord-010092-uftc8inx 6112 2 h. h. NNP cord-010092-uftc8inx 6112 3 LDH LDH NNP cord-010092-uftc8inx 6112 4 increased increase VBD cord-010092-uftc8inx 6112 5 from from IN cord-010092-uftc8inx 6112 6 120.4 120.4 CD cord-010092-uftc8inx 6112 7 AE AE NNP cord-010092-uftc8inx 6112 8 8.6 8.6 CD cord-010092-uftc8inx 6112 9 U u NN cord-010092-uftc8inx 6112 10 / / SYM cord-010092-uftc8inx 6112 11 l l NN cord-010092-uftc8inx 6112 12 at at IN cord-010092-uftc8inx 6112 13 1 1 CD cord-010092-uftc8inx 6112 14 h h NN cord-010092-uftc8inx 6112 15 and and CC cord-010092-uftc8inx 6112 16 125.8 125.8 CD cord-010092-uftc8inx 6112 17 AE AE NNP cord-010092-uftc8inx 6112 18 10.3 10.3 CD cord-010092-uftc8inx 6112 19 U U NNP cord-010092-uftc8inx 6112 20 / / SYM cord-010092-uftc8inx 6112 21 l l NN cord-010092-uftc8inx 6112 22 at at IN cord-010092-uftc8inx 6112 23 8 8 CD cord-010092-uftc8inx 6112 24 h h NN cord-010092-uftc8inx 6112 25 as as IN cord-010092-uftc8inx 6112 26 p p NN cord-010092-uftc8inx 6112 27 - - : cord-010092-uftc8inx 6112 28 selectin selectin NNP cord-010092-uftc8inx 6112 29 45.7 45.7 CD cord-010092-uftc8inx 6112 30 AE AE NNP cord-010092-uftc8inx 6112 31 7.6 7.6 CD cord-010092-uftc8inx 6112 32 ng ng NN cord-010092-uftc8inx 6112 33 / / SYM cord-010092-uftc8inx 6112 34 mL ml NN cord-010092-uftc8inx 6112 35 at at IN cord-010092-uftc8inx 6112 36 1 1 CD cord-010092-uftc8inx 6112 37 h h NN cord-010092-uftc8inx 6112 38 and and CC cord-010092-uftc8inx 6112 39 57.7 57.7 CD cord-010092-uftc8inx 6112 40 AE AE NNP cord-010092-uftc8inx 6113 1 7.0 7.0 CD cord-010092-uftc8inx 6113 2 ng/ ng/ NNP cord-010092-uftc8inx 6113 3 mL. mL. NNS cord-010092-uftc8inx 6113 4 All all DT cord-010092-uftc8inx 6113 5 units unit NNS cord-010092-uftc8inx 6113 6 have have VBP cord-010092-uftc8inx 6113 7 maintained maintain VBN cord-010092-uftc8inx 6113 8 swirling swirl VBG cord-010092-uftc8inx 6113 9 . . . cord-010092-uftc8inx 6114 1 The the DT cord-010092-uftc8inx 6114 2 changes change NNS cord-010092-uftc8inx 6114 3 observed observe VBD cord-010092-uftc8inx 6114 4 during during IN cord-010092-uftc8inx 6114 5 the the DT cord-010092-uftc8inx 6114 6 8-h 8-h CD cord-010092-uftc8inx 6114 7 storage storage NN cord-010092-uftc8inx 6114 8 period period NN cord-010092-uftc8inx 6114 9 appear appear VBP cord-010092-uftc8inx 6114 10 to to TO cord-010092-uftc8inx 6114 11 be be VB cord-010092-uftc8inx 6114 12 limited limited JJ cord-010092-uftc8inx 6114 13 and and CC cord-010092-uftc8inx 6114 14 compatible compatible JJ cord-010092-uftc8inx 6114 15 with with IN cord-010092-uftc8inx 6114 16 a a DT cord-010092-uftc8inx 6114 17 further further JJ cord-010092-uftc8inx 6114 18 PR pr NN cord-010092-uftc8inx 6114 19 process process NN cord-010092-uftc8inx 6114 20 using use VBG cord-010092-uftc8inx 6114 21 a a DT cord-010092-uftc8inx 6114 22 photochemical photochemical JJ cord-010092-uftc8inx 6114 23 treatment treatment NN cord-010092-uftc8inx 6114 24 with with IN cord-010092-uftc8inx 6114 25 INTERCEPT INTERCEPT NNP cord-010092-uftc8inx 6114 26 . . . cord-010092-uftc8inx 6115 1 Summary Summary NNP cord-010092-uftc8inx 6115 2 / / SYM cord-010092-uftc8inx 6115 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 6115 4 : : : cord-010092-uftc8inx 6116 1 Leukocyte Leukocyte NNP cord-010092-uftc8inx 6116 2 - - HYPH cord-010092-uftc8inx 6116 3 depleted deplete VBN cord-010092-uftc8inx 6116 4 " " `` cord-010092-uftc8inx 6116 5 double double JJ cord-010092-uftc8inx 6116 6 dose dose NN cord-010092-uftc8inx 6116 7 " " `` cord-010092-uftc8inx 6116 8 buffy buffy NNP cord-010092-uftc8inx 6116 9 coat coat NN cord-010092-uftc8inx 6116 10 platelets platelet NNS cord-010092-uftc8inx 6116 11 with with IN cord-010092-uftc8inx 6116 12 a a DT cord-010092-uftc8inx 6116 13 high high JJ cord-010092-uftc8inx 6116 14 platelet platelet NN cord-010092-uftc8inx 6116 15 content content NN cord-010092-uftc8inx 6116 16 and and CC cord-010092-uftc8inx 6116 17 ready ready JJ cord-010092-uftc8inx 6116 18 for for IN cord-010092-uftc8inx 6116 19 pathogen pathogen NN cord-010092-uftc8inx 6116 20 reduction reduction NN cord-010092-uftc8inx 6116 21 can can MD cord-010092-uftc8inx 6116 22 be be VB cord-010092-uftc8inx 6116 23 obtained obtain VBN cord-010092-uftc8inx 6116 24 with with IN cord-010092-uftc8inx 6116 25 the the DT cord-010092-uftc8inx 6116 26 platelet platelet NN cord-010092-uftc8inx 6116 27 pooling pooling NN cord-010092-uftc8inx 6116 28 and and CC cord-010092-uftc8inx 6116 29 leukodepletion leukodepletion NN cord-010092-uftc8inx 6116 30 set set VBN cord-010092-uftc8inx 6116 31 developed develop VBN cord-010092-uftc8inx 6116 32 by by IN cord-010092-uftc8inx 6116 33 Fresenius Fresenius NNP cord-010092-uftc8inx 6116 34 . . . cord-010092-uftc8inx 6117 1 A a DT cord-010092-uftc8inx 6117 2 storage storage NN cord-010092-uftc8inx 6117 3 period period NN cord-010092-uftc8inx 6117 4 of of IN cord-010092-uftc8inx 6117 5 8 8 CD cord-010092-uftc8inx 6117 6 h h NN cord-010092-uftc8inx 6117 7 before before IN cord-010092-uftc8inx 6117 8 applying apply VBG cord-010092-uftc8inx 6117 9 the the DT cord-010092-uftc8inx 6117 10 photochemical photochemical JJ cord-010092-uftc8inx 6117 11 treatment treatment NN cord-010092-uftc8inx 6117 12 is be VBZ cord-010092-uftc8inx 6117 13 feasible feasible JJ cord-010092-uftc8inx 6117 14 without without IN cord-010092-uftc8inx 6117 15 significantly significantly RB cord-010092-uftc8inx 6117 16 altering alter VBG cord-010092-uftc8inx 6117 17 the the DT cord-010092-uftc8inx 6117 18 biological biological JJ cord-010092-uftc8inx 6117 19 quality quality NN cord-010092-uftc8inx 6117 20 of of IN cord-010092-uftc8inx 6117 21 platelets platelet NNS cord-010092-uftc8inx 6117 22 . . . cord-010092-uftc8inx 6118 1 Background background NN cord-010092-uftc8inx 6118 2 : : : cord-010092-uftc8inx 6119 1 The the DT cord-010092-uftc8inx 6119 2 Irish Irish NNP cord-010092-uftc8inx 6119 3 Blood Blood NNP cord-010092-uftc8inx 6119 4 Transfusion Transfusion NNP cord-010092-uftc8inx 6119 5 Service Service NNP cord-010092-uftc8inx 6119 6 ( ( -LRB- cord-010092-uftc8inx 6119 7 IBTS IBTS NNP cord-010092-uftc8inx 6119 8 ) ) -RRB- cord-010092-uftc8inx 6119 9 is be VBZ cord-010092-uftc8inx 6119 10 the the DT cord-010092-uftc8inx 6119 11 statutory statutory JJ cord-010092-uftc8inx 6119 12 body body NN cord-010092-uftc8inx 6119 13 with with IN cord-010092-uftc8inx 6119 14 the the DT cord-010092-uftc8inx 6119 15 responsibility responsibility NN cord-010092-uftc8inx 6119 16 for for IN cord-010092-uftc8inx 6119 17 Ireland Ireland NNP cord-010092-uftc8inx 6119 18 's 's POS cord-010092-uftc8inx 6119 19 national national JJ cord-010092-uftc8inx 6119 20 blood blood NN cord-010092-uftc8inx 6119 21 supply supply NN cord-010092-uftc8inx 6119 22 . . . cord-010092-uftc8inx 6120 1 In in IN cord-010092-uftc8inx 6120 2 2018 2018 CD cord-010092-uftc8inx 6120 3 the the DT cord-010092-uftc8inx 6120 4 IBTS IBTS NNP cord-010092-uftc8inx 6120 5 collected collect VBD cord-010092-uftc8inx 6120 6 130,183 130,183 CD cord-010092-uftc8inx 6120 7 whole whole JJ cord-010092-uftc8inx 6120 8 blood blood NN cord-010092-uftc8inx 6120 9 units unit NNS cord-010092-uftc8inx 6120 10 and and CC cord-010092-uftc8inx 6120 11 performed perform VBD cord-010092-uftc8inx 6120 12 9,654 9,654 CD cord-010092-uftc8inx 6120 13 platelet platelet NN cord-010092-uftc8inx 6120 14 apheresis apheresis NN cord-010092-uftc8inx 6120 15 procedures procedure NNS cord-010092-uftc8inx 6120 16 . . . cord-010092-uftc8inx 6121 1 Blood blood NN cord-010092-uftc8inx 6121 2 is be VBZ cord-010092-uftc8inx 6121 3 collected collect VBN cord-010092-uftc8inx 6121 4 in in IN cord-010092-uftc8inx 6121 5 three three CD cord-010092-uftc8inx 6121 6 fixed fix VBN cord-010092-uftc8inx 6121 7 and and CC cord-010092-uftc8inx 6121 8 six six CD cord-010092-uftc8inx 6121 9 mobile mobile JJ cord-010092-uftc8inx 6121 10 sites site NNS cord-010092-uftc8inx 6121 11 and and CC cord-010092-uftc8inx 6121 12 is be VBZ cord-010092-uftc8inx 6121 13 returned return VBN cord-010092-uftc8inx 6121 14 overnight overnight RB cord-010092-uftc8inx 6121 15 in in IN cord-010092-uftc8inx 6121 16 temperature temperature NN cord-010092-uftc8inx 6121 17 controlled control VBN cord-010092-uftc8inx 6121 18 vans van NNS cord-010092-uftc8inx 6121 19 to to IN cord-010092-uftc8inx 6121 20 a a DT cord-010092-uftc8inx 6121 21 single single JJ cord-010092-uftc8inx 6121 22 processing processing NN cord-010092-uftc8inx 6121 23 site site NN cord-010092-uftc8inx 6121 24 . . . cord-010092-uftc8inx 6122 1 In in IN cord-010092-uftc8inx 6122 2 September September NNP cord-010092-uftc8inx 6122 3 2017 2017 CD cord-010092-uftc8inx 6122 4 , , , cord-010092-uftc8inx 6122 5 the the DT cord-010092-uftc8inx 6122 6 IBTS IBTS NNP cord-010092-uftc8inx 6122 7 implemented implement VBD cord-010092-uftc8inx 6122 8 the the DT cord-010092-uftc8inx 6122 9 TACSI TACSI NNP cord-010092-uftc8inx 6122 10 automated automate VBN cord-010092-uftc8inx 6122 11 system system NN cord-010092-uftc8inx 6122 12 for for IN cord-010092-uftc8inx 6122 13 the the DT cord-010092-uftc8inx 6122 14 preparation preparation NN cord-010092-uftc8inx 6122 15 of of IN cord-010092-uftc8inx 6122 16 buffy buffy NNP cord-010092-uftc8inx 6122 17 - - HYPH cord-010092-uftc8inx 6122 18 coat coat NN cord-010092-uftc8inx 6122 19 derived derive VBD cord-010092-uftc8inx 6122 20 platelets platelet NNS cord-010092-uftc8inx 6122 21 as as IN cord-010092-uftc8inx 6122 22 an an DT cord-010092-uftc8inx 6122 23 alternative alternative NN cord-010092-uftc8inx 6122 24 to to IN cord-010092-uftc8inx 6122 25 the the DT cord-010092-uftc8inx 6122 26 OrbiSac OrbiSac NNP cord-010092-uftc8inx 6122 27 system system NN cord-010092-uftc8inx 6122 28 . . . cord-010092-uftc8inx 6123 1 Aims aim VBZ cord-010092-uftc8inx 6123 2 : : : cord-010092-uftc8inx 6124 1 The the DT cord-010092-uftc8inx 6124 2 aim aim NN cord-010092-uftc8inx 6124 3 of of IN cord-010092-uftc8inx 6124 4 this this DT cord-010092-uftc8inx 6124 5 study study NN cord-010092-uftc8inx 6124 6 is be VBZ cord-010092-uftc8inx 6124 7 to to TO cord-010092-uftc8inx 6124 8 compare compare VB cord-010092-uftc8inx 6124 9 operational operational JJ cord-010092-uftc8inx 6124 10 aspects aspect NNS cord-010092-uftc8inx 6124 11 and and CC cord-010092-uftc8inx 6124 12 quality quality NN cord-010092-uftc8inx 6124 13 data datum NNS cord-010092-uftc8inx 6124 14 of of IN cord-010092-uftc8inx 6124 15 buffy buffy NNP cord-010092-uftc8inx 6124 16 - - HYPH cord-010092-uftc8inx 6124 17 coat coat NN cord-010092-uftc8inx 6124 18 derived derive VBD cord-010092-uftc8inx 6124 19 platelets platelet NNS cord-010092-uftc8inx 6124 20 prepared prepare VBN cord-010092-uftc8inx 6124 21 by by IN cord-010092-uftc8inx 6124 22 the the DT cord-010092-uftc8inx 6124 23 TACSI TACSI NNP cord-010092-uftc8inx 6124 24 ( ( -LRB- cord-010092-uftc8inx 6124 25 T T NNP cord-010092-uftc8inx 6124 26 - - HYPH cord-010092-uftc8inx 6124 27 PCs pc NNS cord-010092-uftc8inx 6124 28 ) ) -RRB- cord-010092-uftc8inx 6125 1 and and CC cord-010092-uftc8inx 6125 2 OrbiSac OrbiSac NNP cord-010092-uftc8inx 6125 3 ( ( -LRB- cord-010092-uftc8inx 6125 4 O o NN cord-010092-uftc8inx 6125 5 - - HYPH cord-010092-uftc8inx 6125 6 PCs pc NNS cord-010092-uftc8inx 6125 7 ) ) -RRB- cord-010092-uftc8inx 6125 8 automated automate VBN cord-010092-uftc8inx 6125 9 systems system NNS cord-010092-uftc8inx 6125 10 . . . cord-010092-uftc8inx 6126 1 Methods method NNS cord-010092-uftc8inx 6126 2 : : : cord-010092-uftc8inx 6126 3 QC QC NNP cord-010092-uftc8inx 6126 4 data datum NNS cord-010092-uftc8inx 6126 5 of of IN cord-010092-uftc8inx 6126 6 T T NNP cord-010092-uftc8inx 6126 7 - - HYPH cord-010092-uftc8inx 6126 8 PCs pc NNS cord-010092-uftc8inx 6126 9 and and CC cord-010092-uftc8inx 6126 10 O O NNS cord-010092-uftc8inx 6126 11 - - HYPH cord-010092-uftc8inx 6126 12 PCs pc NNS cord-010092-uftc8inx 6126 13 from from IN cord-010092-uftc8inx 6126 14 years year NNS cord-010092-uftc8inx 6126 15 2016 2016 CD cord-010092-uftc8inx 6126 16 to to IN cord-010092-uftc8inx 6126 17 2018 2018 CD cord-010092-uftc8inx 6126 18 were be VBD cord-010092-uftc8inx 6126 19 analyzed analyze VBN cord-010092-uftc8inx 6126 20 . . . cord-010092-uftc8inx 6127 1 In in IN cord-010092-uftc8inx 6127 2 2016 2016 CD cord-010092-uftc8inx 6127 3 , , , cord-010092-uftc8inx 6127 4 the the DT cord-010092-uftc8inx 6127 5 IBTS IBTS NNP cord-010092-uftc8inx 6127 6 prepared prepare VBD cord-010092-uftc8inx 6127 7 5,609 5,609 CD cord-010092-uftc8inx 6127 8 OrbiSac OrbiSac NNP cord-010092-uftc8inx 6127 9 platelet platelet NN cord-010092-uftc8inx 6127 10 pools pool NNS cord-010092-uftc8inx 6128 1 of of IN cord-010092-uftc8inx 6128 2 which which WDT cord-010092-uftc8inx 6128 3 5,477 5,477 CD cord-010092-uftc8inx 6128 4 were be VBD cord-010092-uftc8inx 6128 5 QC QC NNP cord-010092-uftc8inx 6128 6 tested test VBN cord-010092-uftc8inx 6128 7 . . . cord-010092-uftc8inx 6129 1 In in IN cord-010092-uftc8inx 6129 2 2017 2017 CD cord-010092-uftc8inx 6129 3 5,031 5,031 CD cord-010092-uftc8inx 6129 4 OrbiSac OrbiSac NNP cord-010092-uftc8inx 6129 5 and and CC cord-010092-uftc8inx 6129 6 1,625 1,625 CD cord-010092-uftc8inx 6129 7 TACSI TACSI NNP cord-010092-uftc8inx 6129 8 platelet platelet NN cord-010092-uftc8inx 6129 9 pools pool NNS cord-010092-uftc8inx 6129 10 were be VBD cord-010092-uftc8inx 6129 11 prepared prepare VBN cord-010092-uftc8inx 6129 12 and and CC cord-010092-uftc8inx 6129 13 tested test VBN cord-010092-uftc8inx 6129 14 . . . cord-010092-uftc8inx 6130 1 In in IN cord-010092-uftc8inx 6130 2 2018 2018 CD cord-010092-uftc8inx 6130 3 6,783 6,783 CD cord-010092-uftc8inx 6130 4 TACSI TACSI NNP cord-010092-uftc8inx 6130 5 platelet platelet NN cord-010092-uftc8inx 6130 6 pools pool NNS cord-010092-uftc8inx 6130 7 were be VBD cord-010092-uftc8inx 6130 8 prepared prepare VBN cord-010092-uftc8inx 6130 9 of of IN cord-010092-uftc8inx 6130 10 which which WDT cord-010092-uftc8inx 6130 11 4671 4671 CD cord-010092-uftc8inx 6130 12 were be VBD cord-010092-uftc8inx 6130 13 QC QC NNP cord-010092-uftc8inx 6130 14 tested test VBN cord-010092-uftc8inx 6130 15 . . . cord-010092-uftc8inx 6131 1 QC QC NNP cord-010092-uftc8inx 6131 2 data datum NNS cord-010092-uftc8inx 6131 3 comprised comprise VBD cord-010092-uftc8inx 6131 4 PC pc NN cord-010092-uftc8inx 6131 5 volume volume NN cord-010092-uftc8inx 6131 6 , , , cord-010092-uftc8inx 6131 7 platelet platelet NN cord-010092-uftc8inx 6131 8 content content NN cord-010092-uftc8inx 6131 9 ( ( -LRB- cord-010092-uftc8inx 6131 10 10 10 CD cord-010092-uftc8inx 6131 11 9 9 CD cord-010092-uftc8inx 6131 12 /unit /unit . cord-010092-uftc8inx 6131 13 ) ) -RRB- cord-010092-uftc8inx 6131 14 , , , cord-010092-uftc8inx 6131 15 residual residual JJ cord-010092-uftc8inx 6131 16 leucocyte leucocyte NNP cord-010092-uftc8inx 6131 17 content content NN cord-010092-uftc8inx 6131 18 ( ( -LRB- cord-010092-uftc8inx 6131 19 10 10 CD cord-010092-uftc8inx 6131 20 6 6 CD cord-010092-uftc8inx 6131 21 /unit /unit . cord-010092-uftc8inx 6131 22 ) ) -RRB- cord-010092-uftc8inx 6131 23 and and CC cord-010092-uftc8inx 6131 24 pH ph NN cord-010092-uftc8inx 6131 25 at at IN cord-010092-uftc8inx 6131 26 expiry expiry NN cord-010092-uftc8inx 6131 27 . . . cord-010092-uftc8inx 6132 1 Feedback Feedback NNS cord-010092-uftc8inx 6132 2 from from IN cord-010092-uftc8inx 6132 3 the the DT cord-010092-uftc8inx 6132 4 processing processing NN cord-010092-uftc8inx 6132 5 laboratory laboratory NN cord-010092-uftc8inx 6132 6 operators operator NNS cord-010092-uftc8inx 6132 7 was be VBD cord-010092-uftc8inx 6132 8 collected collect VBN cord-010092-uftc8inx 6132 9 comparing compare VBG cord-010092-uftc8inx 6132 10 operational operational JJ cord-010092-uftc8inx 6132 11 aspects aspect NNS cord-010092-uftc8inx 6132 12 of of IN cord-010092-uftc8inx 6132 13 preparation preparation NN cord-010092-uftc8inx 6132 14 of of IN cord-010092-uftc8inx 6132 15 T T NNP cord-010092-uftc8inx 6132 16 - - HYPH cord-010092-uftc8inx 6132 17 PCs pc NNS cord-010092-uftc8inx 6132 18 and and CC cord-010092-uftc8inx 6132 19 O O NNS cord-010092-uftc8inx 6132 20 - - HYPH cord-010092-uftc8inx 6132 21 PCs pc NNS cord-010092-uftc8inx 6132 22 . . . cord-010092-uftc8inx 6133 1 Results result NNS cord-010092-uftc8inx 6133 2 : : : cord-010092-uftc8inx 6134 1 From from IN cord-010092-uftc8inx 6134 2 the the DT cord-010092-uftc8inx 6134 3 10,508 10,508 CD cord-010092-uftc8inx 6134 4 O o NN cord-010092-uftc8inx 6134 5 - - HYPH cord-010092-uftc8inx 6134 6 PCs pc NNS cord-010092-uftc8inx 6134 7 tested test VBN cord-010092-uftc8inx 6134 8 in in IN cord-010092-uftc8inx 6134 9 2016 2016 CD cord-010092-uftc8inx 6134 10 and and CC cord-010092-uftc8inx 6134 11 2017 2017 CD cord-010092-uftc8inx 6134 12 , , , cord-010092-uftc8inx 6134 13 mean mean JJ cord-010092-uftc8inx 6134 14 PC pc NN cord-010092-uftc8inx 6134 15 volume volume NN cord-010092-uftc8inx 6134 16 was be VBD cord-010092-uftc8inx 6134 17 292 292 CD cord-010092-uftc8inx 6134 18 AE AE NNP cord-010092-uftc8inx 6134 19 9 9 CD cord-010092-uftc8inx 6134 20 ml ml NN cord-010092-uftc8inx 6134 21 . . . cord-010092-uftc8inx 6135 1 Initially initially RB cord-010092-uftc8inx 6135 2 the the DT cord-010092-uftc8inx 6135 3 T T NNP cord-010092-uftc8inx 6135 4 - - HYPH cord-010092-uftc8inx 6135 5 PCs pc NNS cord-010092-uftc8inx 6135 6 mean mean VBP cord-010092-uftc8inx 6135 7 volume volume NN cord-010092-uftc8inx 6135 8 was be VBD cord-010092-uftc8inx 6135 9 273 273 CD cord-010092-uftc8inx 6135 10 AE AE NNP cord-010092-uftc8inx 6135 11 13 13 CD cord-010092-uftc8inx 6135 12 ml ml NN cord-010092-uftc8inx 6136 1 but but CC cord-010092-uftc8inx 6136 2 more more RBR cord-010092-uftc8inx 6136 3 recently recently RB cord-010092-uftc8inx 6136 4 the the DT cord-010092-uftc8inx 6136 5 volumes volume NNS cord-010092-uftc8inx 6136 6 were be VBD cord-010092-uftc8inx 6136 7 increased increase VBN cord-010092-uftc8inx 6136 8 by by IN cord-010092-uftc8inx 6136 9 addition addition NN cord-010092-uftc8inx 6136 10 of of IN cord-010092-uftc8inx 6136 11 a a DT cord-010092-uftc8inx 6136 12 larger large JJR cord-010092-uftc8inx 6136 13 volume volume NN cord-010092-uftc8inx 6136 14 of of IN cord-010092-uftc8inx 6136 15 additive additive NN cord-010092-uftc8inx 6136 16 solution solution NN cord-010092-uftc8inx 6136 17 to to IN cord-010092-uftc8inx 6136 18 303 303 CD cord-010092-uftc8inx 6136 19 AE AE NNP cord-010092-uftc8inx 6136 20 13 13 CD cord-010092-uftc8inx 6136 21 ml ml NNS cord-010092-uftc8inx 6136 22 . . . cord-010092-uftc8inx 6137 1 Platelet platelet NN cord-010092-uftc8inx 6137 2 content content NN cord-010092-uftc8inx 6137 3 ( ( -LRB- cord-010092-uftc8inx 6137 4 10 10 CD cord-010092-uftc8inx 6137 5 9 9 CD cord-010092-uftc8inx 6137 6 /unit /unit . cord-010092-uftc8inx 6137 7 ) ) -RRB- cord-010092-uftc8inx 6137 8 was be VBD cord-010092-uftc8inx 6137 9 significantly significantly RB cord-010092-uftc8inx 6137 10 improved improve VBN cord-010092-uftc8inx 6137 11 in in IN cord-010092-uftc8inx 6137 12 T T NNP cord-010092-uftc8inx 6137 13 - - HYPH cord-010092-uftc8inx 6137 14 PCs pc NNS cord-010092-uftc8inx 6137 15 ( ( -LRB- cord-010092-uftc8inx 6137 16 384 384 CD cord-010092-uftc8inx 6137 17 AE AE NNP cord-010092-uftc8inx 6137 18 47 47 CD cord-010092-uftc8inx 6137 19 ) ) -RRB- cord-010092-uftc8inx 6137 20 compared compare VBN cord-010092-uftc8inx 6137 21 to to IN cord-010092-uftc8inx 6137 22 O o NN cord-010092-uftc8inx 6137 23 - - HYPH cord-010092-uftc8inx 6137 24 PCs pc NNS cord-010092-uftc8inx 6137 25 ( ( -LRB- cord-010092-uftc8inx 6137 26 356 356 CD cord-010092-uftc8inx 6137 27 AE AE NNP cord-010092-uftc8inx 6137 28 50 50 CD cord-010092-uftc8inx 6137 29 ) ) -RRB- cord-010092-uftc8inx 6138 1 [ [ -LRB- cord-010092-uftc8inx 6138 2 P p NN cord-010092-uftc8inx 6138 3 < < XX cord-010092-uftc8inx 6138 4 0.01 0.01 CD cord-010092-uftc8inx 6138 5 ] ] -RRB- cord-010092-uftc8inx 6138 6 as as RB cord-010092-uftc8inx 6138 7 well well RB cord-010092-uftc8inx 6138 8 as as IN cord-010092-uftc8inx 6138 9 residual residual JJ cord-010092-uftc8inx 6138 10 leucocyte leucocyte NNP cord-010092-uftc8inx 6138 11 content content NN cord-010092-uftc8inx 6138 12 ( ( -LRB- cord-010092-uftc8inx 6138 13 10 10 CD cord-010092-uftc8inx 6138 14 6 6 CD cord-010092-uftc8inx 6138 15 /unit /unit . cord-010092-uftc8inx 6138 16 ) ) -RRB- cord-010092-uftc8inx 6138 17 which which WDT cord-010092-uftc8inx 6138 18 was be VBD cord-010092-uftc8inx 6138 19 lower low JJR cord-010092-uftc8inx 6138 20 in in IN cord-010092-uftc8inx 6138 21 T T NNP cord-010092-uftc8inx 6138 22 - - HYPH cord-010092-uftc8inx 6138 23 PCs pc NNS cord-010092-uftc8inx 6138 24 ( ( -LRB- cord-010092-uftc8inx 6138 25 0.05 0.05 CD cord-010092-uftc8inx 6138 26 AE AE NNP cord-010092-uftc8inx 6138 27 0.04 0.04 CD cord-010092-uftc8inx 6138 28 ) ) -RRB- cord-010092-uftc8inx 6138 29 compared compare VBN cord-010092-uftc8inx 6138 30 to to IN cord-010092-uftc8inx 6138 31 O o NN cord-010092-uftc8inx 6138 32 - - HYPH cord-010092-uftc8inx 6138 33 PCs pc NNS cord-010092-uftc8inx 6138 34 ( ( -LRB- cord-010092-uftc8inx 6138 35 0.1 0.1 CD cord-010092-uftc8inx 6138 36 AE AE NNP cord-010092-uftc8inx 6138 37 0.2 0.2 CD cord-010092-uftc8inx 6138 38 ) ) -RRB- cord-010092-uftc8inx 6139 1 [ [ -LRB- cord-010092-uftc8inx 6139 2 P p NN cord-010092-uftc8inx 6139 3 < < XX cord-010092-uftc8inx 6139 4 0.01 0.01 CD cord-010092-uftc8inx 6139 5 ] ] -RRB- cord-010092-uftc8inx 6139 6 . . . cord-010092-uftc8inx 6140 1 pH pH NNP cord-010092-uftc8inx 6140 2 at at IN cord-010092-uftc8inx 6140 3 expiry expiry NN cord-010092-uftc8inx 6140 4 was be VBD cord-010092-uftc8inx 6140 5 lower low JJR cord-010092-uftc8inx 6140 6 in in IN cord-010092-uftc8inx 6140 7 T T NNP cord-010092-uftc8inx 6140 8 - - HYPH cord-010092-uftc8inx 6140 9 PCs pc NNS cord-010092-uftc8inx 6140 10 ( ( -LRB- cord-010092-uftc8inx 6140 11 7.32 7.32 CD cord-010092-uftc8inx 6140 12 AE AE NNP cord-010092-uftc8inx 6140 13 0.07 0.07 CD cord-010092-uftc8inx 6140 14 ) ) -RRB- cord-010092-uftc8inx 6140 15 compared compare VBN cord-010092-uftc8inx 6140 16 to to IN cord-010092-uftc8inx 6140 17 0-PCs 0-pcs CD cord-010092-uftc8inx 6140 18 ( ( -LRB- cord-010092-uftc8inx 6140 19 7.38 7.38 CD cord-010092-uftc8inx 6140 20 AE AE NNP cord-010092-uftc8inx 6140 21 0.06 0.06 CD cord-010092-uftc8inx 6140 22 ) ) -RRB- cord-010092-uftc8inx 6140 23 but but CC cord-010092-uftc8inx 6140 24 remained remain VBD cord-010092-uftc8inx 6140 25 within within IN cord-010092-uftc8inx 6140 26 the the DT cord-010092-uftc8inx 6140 27 quality quality NN cord-010092-uftc8inx 6140 28 requirements requirement NNS cord-010092-uftc8inx 6140 29 . . . cord-010092-uftc8inx 6141 1 From from IN cord-010092-uftc8inx 6141 2 an an DT cord-010092-uftc8inx 6141 3 operational operational JJ cord-010092-uftc8inx 6141 4 perspective perspective NN cord-010092-uftc8inx 6141 5 with with IN cord-010092-uftc8inx 6141 6 two two CD cord-010092-uftc8inx 6141 7 TACSI TACSI NNP cord-010092-uftc8inx 6141 8 devices device NNS cord-010092-uftc8inx 6141 9 , , , cord-010092-uftc8inx 6141 10 five five CD cord-010092-uftc8inx 6141 11 operators operator NNS cord-010092-uftc8inx 6141 12 produce produce VBP cord-010092-uftc8inx 6141 13 approximately approximately RB cord-010092-uftc8inx 6141 14 48 48 CD cord-010092-uftc8inx 6141 15 T t NN cord-010092-uftc8inx 6141 16 - - HYPH cord-010092-uftc8inx 6141 17 PCs pc NNS cord-010092-uftc8inx 6141 18 per per IN cord-010092-uftc8inx 6141 19 hour hour NN cord-010092-uftc8inx 6141 20 compared compare VBN cord-010092-uftc8inx 6141 21 to to IN cord-010092-uftc8inx 6141 22 a a DT cord-010092-uftc8inx 6141 23 lower low JJR cord-010092-uftc8inx 6141 24 throughput throughput NN cord-010092-uftc8inx 6141 25 of of IN cord-010092-uftc8inx 6141 26 20 20 CD cord-010092-uftc8inx 6141 27 O o NN cord-010092-uftc8inx 6141 28 - - HYPH cord-010092-uftc8inx 6141 29 PCs pc NNS cord-010092-uftc8inx 6141 30 per per IN cord-010092-uftc8inx 6141 31 hour hour NN cord-010092-uftc8inx 6141 32 with with IN cord-010092-uftc8inx 6141 33 five five CD cord-010092-uftc8inx 6141 34 OrbiSac OrbiSac NNP cord-010092-uftc8inx 6141 35 devices device NNS cord-010092-uftc8inx 6141 36 . . . cord-010092-uftc8inx 6142 1 The the DT cord-010092-uftc8inx 6142 2 TACSI TACSI NNP cord-010092-uftc8inx 6142 3 system system NN cord-010092-uftc8inx 6142 4 is be VBZ cord-010092-uftc8inx 6142 5 more more RBR cord-010092-uftc8inx 6142 6 compatible compatible JJ cord-010092-uftc8inx 6142 7 with with IN cord-010092-uftc8inx 6142 8 batch batch NN cord-010092-uftc8inx 6142 9 processing processing NN cord-010092-uftc8inx 6142 10 which which WDT cord-010092-uftc8inx 6142 11 aligns align VBZ cord-010092-uftc8inx 6142 12 with with IN cord-010092-uftc8inx 6142 13 our -PRON- PRP$ cord-010092-uftc8inx 6142 14 staffing staffing NN cord-010092-uftc8inx 6142 15 arrangements arrangement NNS cord-010092-uftc8inx 6142 16 in in IN cord-010092-uftc8inx 6142 17 routine routine JJ cord-010092-uftc8inx 6142 18 production production NN cord-010092-uftc8inx 6142 19 and and CC cord-010092-uftc8inx 6142 20 has have VBZ cord-010092-uftc8inx 6142 21 resulted result VBN cord-010092-uftc8inx 6142 22 in in IN cord-010092-uftc8inx 6142 23 greater great JJR cord-010092-uftc8inx 6142 24 productivity productivity NN cord-010092-uftc8inx 6142 25 since since IN cord-010092-uftc8inx 6142 26 its -PRON- PRP$ cord-010092-uftc8inx 6142 27 introduction introduction NN cord-010092-uftc8inx 6142 28 . . . cord-010092-uftc8inx 6143 1 With with IN cord-010092-uftc8inx 6143 2 TACSI TACSI NNP cord-010092-uftc8inx 6143 3 implementation implementation NN cord-010092-uftc8inx 6143 4 , , , cord-010092-uftc8inx 6143 5 we -PRON- PRP cord-010092-uftc8inx 6143 6 reverted revert VBD cord-010092-uftc8inx 6143 7 to to IN cord-010092-uftc8inx 6143 8 manual manual JJ cord-010092-uftc8inx 6143 9 pooling pooling NN cord-010092-uftc8inx 6143 10 of of IN cord-010092-uftc8inx 6143 11 buffy buffy NNP cord-010092-uftc8inx 6143 12 coats coat NNS cord-010092-uftc8inx 6143 13 and and CC cord-010092-uftc8inx 6143 14 new new JJ cord-010092-uftc8inx 6143 15 staff staff NN cord-010092-uftc8inx 6143 16 had have VBD cord-010092-uftc8inx 6143 17 to to TO cord-010092-uftc8inx 6143 18 undergo undergo VB cord-010092-uftc8inx 6143 19 training training NN cord-010092-uftc8inx 6143 20 to to TO cord-010092-uftc8inx 6143 21 achieve achieve VB cord-010092-uftc8inx 6143 22 optimal optimal JJ cord-010092-uftc8inx 6143 23 platelet platelet NN cord-010092-uftc8inx 6143 24 recovery recovery NN cord-010092-uftc8inx 6143 25 . . . cord-010092-uftc8inx 6144 1 Once once RB cord-010092-uftc8inx 6144 2 staff staff NN cord-010092-uftc8inx 6144 3 were be VBD cord-010092-uftc8inx 6144 4 trained train VBN cord-010092-uftc8inx 6144 5 during during IN cord-010092-uftc8inx 6144 6 validation validation NN cord-010092-uftc8inx 6144 7 , , , cord-010092-uftc8inx 6144 8 we -PRON- PRP cord-010092-uftc8inx 6144 9 observed observe VBD cord-010092-uftc8inx 6144 10 a a DT cord-010092-uftc8inx 6144 11 10 10 CD cord-010092-uftc8inx 6144 12 % % NN cord-010092-uftc8inx 6144 13 increase increase NN cord-010092-uftc8inx 6144 14 in in IN cord-010092-uftc8inx 6144 15 platelet platelet NN cord-010092-uftc8inx 6144 16 recovery recovery NN cord-010092-uftc8inx 6144 17 . . . cord-010092-uftc8inx 6145 1 Processing process VBG cord-010092-uftc8inx 6145 2 laboratory laboratory NN cord-010092-uftc8inx 6145 3 staff staff NN cord-010092-uftc8inx 6145 4 indicated indicate VBD cord-010092-uftc8inx 6145 5 that that IN cord-010092-uftc8inx 6145 6 TACSI TACSI NNP cord-010092-uftc8inx 6145 7 devices device NNS cord-010092-uftc8inx 6145 8 were be VBD cord-010092-uftc8inx 6145 9 easier easy JJR cord-010092-uftc8inx 6145 10 and and CC cord-010092-uftc8inx 6145 11 simpler simple JJR cord-010092-uftc8inx 6145 12 to to TO cord-010092-uftc8inx 6145 13 maintain maintain VB cord-010092-uftc8inx 6145 14 in in IN cord-010092-uftc8inx 6145 15 comparison comparison NN cord-010092-uftc8inx 6145 16 to to IN cord-010092-uftc8inx 6145 17 OrbiSac OrbiSac NNP cord-010092-uftc8inx 6145 18 , , , cord-010092-uftc8inx 6145 19 but but CC cord-010092-uftc8inx 6145 20 highlighted highlight VBD cord-010092-uftc8inx 6145 21 that that IN cord-010092-uftc8inx 6145 22 some some DT cord-010092-uftc8inx 6145 23 improvements improvement NNS cord-010092-uftc8inx 6145 24 to to IN cord-010092-uftc8inx 6145 25 TACSI TACSI NNP cord-010092-uftc8inx 6145 26 system system NN cord-010092-uftc8inx 6145 27 boxes box NNS cord-010092-uftc8inx 6145 28 could could MD cord-010092-uftc8inx 6145 29 be be VB cord-010092-uftc8inx 6145 30 made make VBN cord-010092-uftc8inx 6145 31 to to TO cord-010092-uftc8inx 6145 32 make make VB cord-010092-uftc8inx 6145 33 the the DT cord-010092-uftc8inx 6145 34 system system NN cord-010092-uftc8inx 6145 35 more more RBR cord-010092-uftc8inx 6145 36 robust robust JJ cord-010092-uftc8inx 6145 37 . . . cord-010092-uftc8inx 6146 1 Summary Summary NNP cord-010092-uftc8inx 6146 2 / / SYM cord-010092-uftc8inx 6146 3 Conclusions conclusion NNS cord-010092-uftc8inx 6146 4 : : : cord-010092-uftc8inx 6146 5 PCs pc NNS cord-010092-uftc8inx 6146 6 prepared prepare VBN cord-010092-uftc8inx 6146 7 with with IN cord-010092-uftc8inx 6146 8 TACSI TACSI NNP cord-010092-uftc8inx 6146 9 and and CC cord-010092-uftc8inx 6146 10 OrbiSac OrbiSac NNP cord-010092-uftc8inx 6146 11 automated automate VBN cord-010092-uftc8inx 6146 12 systems system NNS cord-010092-uftc8inx 6147 1 both both DT cord-010092-uftc8inx 6147 2 met meet VBD cord-010092-uftc8inx 6147 3 national national JJ cord-010092-uftc8inx 6147 4 and and CC cord-010092-uftc8inx 6147 5 European european JJ cord-010092-uftc8inx 6147 6 quality quality NN cord-010092-uftc8inx 6147 7 requirements requirement NNS cord-010092-uftc8inx 6147 8 , , , cord-010092-uftc8inx 6147 9 however however RB cord-010092-uftc8inx 6147 10 we -PRON- PRP cord-010092-uftc8inx 6147 11 observed observe VBD cord-010092-uftc8inx 6147 12 a a DT cord-010092-uftc8inx 6147 13 significant significant JJ cord-010092-uftc8inx 6147 14 improvement improvement NN cord-010092-uftc8inx 6147 15 in in IN cord-010092-uftc8inx 6147 16 quality quality NN cord-010092-uftc8inx 6147 17 markers marker NNS cord-010092-uftc8inx 6147 18 of of IN cord-010092-uftc8inx 6147 19 PCs pc NNS cord-010092-uftc8inx 6147 20 prepared prepare VBN cord-010092-uftc8inx 6147 21 with with IN cord-010092-uftc8inx 6147 22 TACSI TACSI NNP cord-010092-uftc8inx 6147 23 . . . cord-010092-uftc8inx 6148 1 Processing processing NN cord-010092-uftc8inx 6148 2 staff staff NN cord-010092-uftc8inx 6148 3 reported report VBD cord-010092-uftc8inx 6148 4 easier easy JJR cord-010092-uftc8inx 6148 5 maintenance maintenance NN cord-010092-uftc8inx 6148 6 and and CC cord-010092-uftc8inx 6148 7 processing processing NN cord-010092-uftc8inx 6148 8 with with IN cord-010092-uftc8inx 6148 9 TACSI TACSI NNP cord-010092-uftc8inx 6148 10 compared compare VBN cord-010092-uftc8inx 6148 11 to to IN cord-010092-uftc8inx 6148 12 OrbiSac OrbiSac NNP cord-010092-uftc8inx 6148 13 . . . cord-010092-uftc8inx 6149 1 Throughput Throughput NNP cord-010092-uftc8inx 6149 2 is be VBZ cord-010092-uftc8inx 6149 3 higher high JJR cord-010092-uftc8inx 6149 4 with with IN cord-010092-uftc8inx 6149 5 TACSI TACSI NNP cord-010092-uftc8inx 6149 6 and and CC cord-010092-uftc8inx 6149 7 there there EX cord-010092-uftc8inx 6149 8 is be VBZ cord-010092-uftc8inx 6149 9 greater great JJR cord-010092-uftc8inx 6149 10 additional additional JJ cord-010092-uftc8inx 6149 11 capacity capacity NN cord-010092-uftc8inx 6149 12 to to TO cord-010092-uftc8inx 6149 13 increase increase VB cord-010092-uftc8inx 6149 14 production production NN cord-010092-uftc8inx 6149 15 in in IN cord-010092-uftc8inx 6149 16 the the DT cord-010092-uftc8inx 6149 17 future future NN cord-010092-uftc8inx 6149 18 if if IN cord-010092-uftc8inx 6149 19 required require VBN cord-010092-uftc8inx 6149 20 . . . cord-010092-uftc8inx 6150 1 A a DT cord-010092-uftc8inx 6150 2 Perez Perez NNP cord-010092-uftc8inx 6150 3 Aliaga Aliaga NNP cord-010092-uftc8inx 6150 4 1 1 CD cord-010092-uftc8inx 6150 5 , , , cord-010092-uftc8inx 6150 6 F F NNP cord-010092-uftc8inx 6150 7 Puente Puente NNP cord-010092-uftc8inx 6150 8 1 1 CD cord-010092-uftc8inx 6150 9 , , , cord-010092-uftc8inx 6150 10 A a DT cord-010092-uftc8inx 6150 11 Aranda Aranda NNP cord-010092-uftc8inx 6150 12 1 1 CD cord-010092-uftc8inx 6150 13 , , , cord-010092-uftc8inx 6150 14 J J NNP cord-010092-uftc8inx 6150 15 Domingo Domingo NNP cord-010092-uftc8inx 6150 16 1 1 CD cord-010092-uftc8inx 6151 1 , , , cord-010092-uftc8inx 6151 2 L L NNP cord-010092-uftc8inx 6151 3 Call Call NNP cord-010092-uftc8inx 6151 4 en en NNP cord-010092-uftc8inx 6151 5 1 1 CD cord-010092-uftc8inx 6151 6 and and CC cord-010092-uftc8inx 6151 7 A a DT cord-010092-uftc8inx 6151 8 Bah bah NN cord-010092-uftc8inx 6151 9 2 2 CD cord-010092-uftc8inx 6151 10 1 1 CD cord-010092-uftc8inx 6151 11 Banco Banco NNP cord-010092-uftc8inx 6151 12 de de NNP cord-010092-uftc8inx 6151 13 Sangre Sangre NNP cord-010092-uftc8inx 6151 14 y y NNP cord-010092-uftc8inx 6151 15 Tejidos Tejidos NNP cord-010092-uftc8inx 6151 16 de de NNP cord-010092-uftc8inx 6151 17 Arag Arag NNP cord-010092-uftc8inx 6151 18 on on IN cord-010092-uftc8inx 6151 19 , , , cord-010092-uftc8inx 6151 20 Aragon Aragon NNP cord-010092-uftc8inx 6151 21 , , , cord-010092-uftc8inx 6151 22 Spain Spain NNP cord-010092-uftc8inx 6151 23 2 2 CD cord-010092-uftc8inx 6151 24 Terumo Terumo NNP cord-010092-uftc8inx 6151 25 BCT BCT NNP cord-010092-uftc8inx 6151 26 Europe Europe NNP cord-010092-uftc8inx 6151 27 N.V. N.V. NNP cord-010092-uftc8inx 6151 28 , , , cord-010092-uftc8inx 6151 29 Zaventem Zaventem NNP cord-010092-uftc8inx 6151 30 , , , cord-010092-uftc8inx 6152 1 Belgium Belgium NNP cord-010092-uftc8inx 6152 2 Background Background NNP cord-010092-uftc8inx 6152 3 : : : cord-010092-uftc8inx 6153 1 The the DT cord-010092-uftc8inx 6153 2 Blood Blood NNP cord-010092-uftc8inx 6153 3 Bank Bank NNP cord-010092-uftc8inx 6153 4 and and CC cord-010092-uftc8inx 6153 5 Tissues Tissues NNPS cord-010092-uftc8inx 6153 6 of of IN cord-010092-uftc8inx 6153 7 Arag Arag NNP cord-010092-uftc8inx 6153 8 on on IN cord-010092-uftc8inx 6153 9 ( ( -LRB- cord-010092-uftc8inx 6153 10 BSTA BSTA NNP cord-010092-uftc8inx 6153 11 ) ) -RRB- cord-010092-uftc8inx 6153 12 is be VBZ cord-010092-uftc8inx 6153 13 responsible responsible JJ cord-010092-uftc8inx 6153 14 for for IN cord-010092-uftc8inx 6153 15 the the DT cord-010092-uftc8inx 6153 16 collection collection NN cord-010092-uftc8inx 6153 17 , , , cord-010092-uftc8inx 6153 18 processing processing NN cord-010092-uftc8inx 6153 19 and and CC cord-010092-uftc8inx 6153 20 distribution distribution NN cord-010092-uftc8inx 6153 21 of of IN cord-010092-uftc8inx 6153 22 blood blood NN cord-010092-uftc8inx 6153 23 in in IN cord-010092-uftc8inx 6153 24 the the DT cord-010092-uftc8inx 6153 25 region region NN cord-010092-uftc8inx 6153 26 of of IN cord-010092-uftc8inx 6153 27 Aragon Aragon NNP cord-010092-uftc8inx 6153 28 in in IN cord-010092-uftc8inx 6153 29 Spain Spain NNP cord-010092-uftc8inx 6153 30 . . . cord-010092-uftc8inx 6154 1 With with IN cord-010092-uftc8inx 6154 2 five five CD cord-010092-uftc8inx 6154 3 fixed fix VBN cord-010092-uftc8inx 6154 4 and and CC cord-010092-uftc8inx 6154 5 five five CD cord-010092-uftc8inx 6154 6 mobile mobile JJ cord-010092-uftc8inx 6154 7 sites site NNS cord-010092-uftc8inx 6154 8 , , , cord-010092-uftc8inx 6154 9 the the DT cord-010092-uftc8inx 6154 10 BSTA BSTA NNP cord-010092-uftc8inx 6154 11 collects collect VBZ cord-010092-uftc8inx 6154 12 and and CC cord-010092-uftc8inx 6154 13 processes process VBZ cord-010092-uftc8inx 6154 14 44,000 44,000 CD cord-010092-uftc8inx 6154 15 whole whole JJ cord-010092-uftc8inx 6154 16 blood blood NN cord-010092-uftc8inx 6154 17 units unit NNS cord-010092-uftc8inx 6154 18 per per IN cord-010092-uftc8inx 6154 19 year year NN cord-010092-uftc8inx 6154 20 . . . cord-010092-uftc8inx 6155 1 To to TO cord-010092-uftc8inx 6155 2 improve improve VB cord-010092-uftc8inx 6155 3 quality quality NN cord-010092-uftc8inx 6155 4 of of IN cord-010092-uftc8inx 6155 5 processed process VBN cord-010092-uftc8inx 6155 6 units unit NNS cord-010092-uftc8inx 6155 7 and and CC cord-010092-uftc8inx 6155 8 working working NN cord-010092-uftc8inx 6155 9 conditions condition NNS cord-010092-uftc8inx 6155 10 of of IN cord-010092-uftc8inx 6155 11 personnel personnel NNS cord-010092-uftc8inx 6155 12 , , , cord-010092-uftc8inx 6155 13 the the DT cord-010092-uftc8inx 6155 14 BSTA BSTA NNP cord-010092-uftc8inx 6155 15 decided decide VBD cord-010092-uftc8inx 6155 16 to to TO cord-010092-uftc8inx 6155 17 implement implement VB cord-010092-uftc8inx 6155 18 the the DT cord-010092-uftc8inx 6155 19 Reveos Reveos NNP cord-010092-uftc8inx 6155 20 automated automate VBN cord-010092-uftc8inx 6155 21 system system NN cord-010092-uftc8inx 6155 22 . . . cord-010092-uftc8inx 6156 1 Validation validation NN cord-010092-uftc8inx 6156 2 studies study NNS cord-010092-uftc8inx 6156 3 were be VBD cord-010092-uftc8inx 6156 4 carried carry VBN cord-010092-uftc8inx 6156 5 out out RP cord-010092-uftc8inx 6156 6 in in IN cord-010092-uftc8inx 6156 7 November November NNP cord-010092-uftc8inx 6156 8 2012 2012 CD cord-010092-uftc8inx 6156 9 and and CC cord-010092-uftc8inx 6156 10 routine routine JJ cord-010092-uftc8inx 6156 11 use use NN cord-010092-uftc8inx 6156 12 started start VBD cord-010092-uftc8inx 6156 13 in in IN cord-010092-uftc8inx 6156 14 July July NNP cord-010092-uftc8inx 6156 15 2013 2013 CD cord-010092-uftc8inx 6156 16 . . . cord-010092-uftc8inx 6157 1 In in IN cord-010092-uftc8inx 6157 2 parallel parallel NN cord-010092-uftc8inx 6157 3 , , , cord-010092-uftc8inx 6157 4 the the DT cord-010092-uftc8inx 6157 5 BSTA BSTA NNP cord-010092-uftc8inx 6157 6 initiated initiate VBD cord-010092-uftc8inx 6157 7 pathogen pathogen NN cord-010092-uftc8inx 6157 8 inactivation inactivation NN cord-010092-uftc8inx 6157 9 of of IN cord-010092-uftc8inx 6157 10 platelet platelet NN cord-010092-uftc8inx 6157 11 concentrates concentrate NNS cord-010092-uftc8inx 6157 12 ( ( -LRB- cord-010092-uftc8inx 6157 13 PC pc NN cord-010092-uftc8inx 6157 14 ) ) -RRB- cord-010092-uftc8inx 6157 15 in in IN cord-010092-uftc8inx 6157 16 November November NNP cord-010092-uftc8inx 6157 17 2012 2012 CD cord-010092-uftc8inx 6157 18 to to TO cord-010092-uftc8inx 6157 19 improve improve VB cord-010092-uftc8inx 6157 20 transfusion transfusion NN cord-010092-uftc8inx 6157 21 safety safety NN cord-010092-uftc8inx 6157 22 . . . cord-010092-uftc8inx 6158 1 In in IN cord-010092-uftc8inx 6158 2 November November NNP cord-010092-uftc8inx 6158 3 2015 2015 CD cord-010092-uftc8inx 6158 4 , , , cord-010092-uftc8inx 6158 5 the the DT cord-010092-uftc8inx 6158 6 Mirasol Mirasol NNP cord-010092-uftc8inx 6158 7 PRT PRT NNP cord-010092-uftc8inx 6158 8 system system NN cord-010092-uftc8inx 6158 9 was be VBD cord-010092-uftc8inx 6158 10 implemented implement VBN cord-010092-uftc8inx 6158 11 due due IN cord-010092-uftc8inx 6158 12 to to IN cord-010092-uftc8inx 6158 13 simplicity simplicity NN cord-010092-uftc8inx 6158 14 of of IN cord-010092-uftc8inx 6158 15 this this DT cord-010092-uftc8inx 6158 16 platform platform NN cord-010092-uftc8inx 6158 17 . . . cord-010092-uftc8inx 6159 1 Aims aim VBZ cord-010092-uftc8inx 6159 2 : : : cord-010092-uftc8inx 6160 1 The the DT cord-010092-uftc8inx 6160 2 aim aim NN cord-010092-uftc8inx 6160 3 of of IN cord-010092-uftc8inx 6160 4 this this DT cord-010092-uftc8inx 6160 5 abstract abstract NN cord-010092-uftc8inx 6160 6 is be VBZ cord-010092-uftc8inx 6160 7 to to IN cord-010092-uftc8inx 6160 8 ( ( -LRB- cord-010092-uftc8inx 6160 9 i i NN cord-010092-uftc8inx 6160 10 ) ) -RRB- cord-010092-uftc8inx 6160 11 describe describe VBP cord-010092-uftc8inx 6160 12 the the DT cord-010092-uftc8inx 6160 13 results result NNS cord-010092-uftc8inx 6160 14 of of IN cord-010092-uftc8inx 6160 15 the the DT cord-010092-uftc8inx 6160 16 validation validation NN cord-010092-uftc8inx 6160 17 studies study NNS cord-010092-uftc8inx 6160 18 carried carry VBN cord-010092-uftc8inx 6160 19 out out RP cord-010092-uftc8inx 6160 20 during during IN cord-010092-uftc8inx 6160 21 Reveos Reveos NNP cord-010092-uftc8inx 6160 22 implementation implementation NN cord-010092-uftc8inx 6160 23 ( ( -LRB- cord-010092-uftc8inx 6160 24 ii ii NN cord-010092-uftc8inx 6160 25 ) ) -RRB- cord-010092-uftc8inx 6160 26 present present JJ cord-010092-uftc8inx 6160 27 routine routine JJ cord-010092-uftc8inx 6160 28 use use NN cord-010092-uftc8inx 6160 29 data datum NNS cord-010092-uftc8inx 6160 30 of of IN cord-010092-uftc8inx 6160 31 products product NNS cord-010092-uftc8inx 6160 32 processed process VBN cord-010092-uftc8inx 6160 33 with with IN cord-010092-uftc8inx 6160 34 Reveos Reveos NNP cord-010092-uftc8inx 6160 35 and and CC cord-010092-uftc8inx 6160 36 ( ( -LRB- cord-010092-uftc8inx 6160 37 iii iii LS cord-010092-uftc8inx 6160 38 ) ) -RRB- cord-010092-uftc8inx 6160 39 provide provide VB cord-010092-uftc8inx 6160 40 information information NN cord-010092-uftc8inx 6160 41 on on IN cord-010092-uftc8inx 6160 42 Mirasol Mirasol NNP cord-010092-uftc8inx 6160 43 implementation implementation NN cord-010092-uftc8inx 6160 44 . . . cord-010092-uftc8inx 6161 1 Methods method NNS cord-010092-uftc8inx 6161 2 : : : cord-010092-uftc8inx 6161 3 In in IN cord-010092-uftc8inx 6161 4 2012 2012 CD cord-010092-uftc8inx 6161 5 , , , cord-010092-uftc8inx 6161 6 369 369 CD cord-010092-uftc8inx 6161 7 whole whole JJ cord-010092-uftc8inx 6161 8 blood blood NN cord-010092-uftc8inx 6161 9 units unit NNS cord-010092-uftc8inx 6161 10 were be VBD cord-010092-uftc8inx 6161 11 processed process VBN cord-010092-uftc8inx 6161 12 using use VBG cord-010092-uftc8inx 6161 13 Reveos Reveos NNP cord-010092-uftc8inx 6161 14 . . . cord-010092-uftc8inx 6162 1 Quality quality NN cord-010092-uftc8inx 6162 2 parameters parameter NNS cord-010092-uftc8inx 6162 3 for for IN cord-010092-uftc8inx 6162 4 red red JJ cord-010092-uftc8inx 6162 5 cell cell NN cord-010092-uftc8inx 6162 6 concentrates concentrate VBZ cord-010092-uftc8inx 6162 7 ( ( -LRB- cord-010092-uftc8inx 6162 8 RCC RCC NNP cord-010092-uftc8inx 6162 9 ) ) -RRB- cord-010092-uftc8inx 6162 10 , , , cord-010092-uftc8inx 6162 11 such such JJ cord-010092-uftc8inx 6162 12 as as IN cord-010092-uftc8inx 6162 13 : : : cord-010092-uftc8inx 6162 14 hemoglobin hemoglobin NN cord-010092-uftc8inx 6162 15 ( ( -LRB- cord-010092-uftc8inx 6162 16 Hb Hb NNP cord-010092-uftc8inx 6162 17 ) ) -RRB- cord-010092-uftc8inx 6162 18 , , , cord-010092-uftc8inx 6162 19 hematocrit hematocrit NN cord-010092-uftc8inx 6162 20 ( ( -LRB- cord-010092-uftc8inx 6162 21 Hct Hct NNP cord-010092-uftc8inx 6162 22 ) ) -RRB- cord-010092-uftc8inx 6162 23 and and CC cord-010092-uftc8inx 6162 24 volume volume NN cord-010092-uftc8inx 6162 25 ; ; : cord-010092-uftc8inx 6162 26 plasma plasma NN cord-010092-uftc8inx 6162 27 : : : cord-010092-uftc8inx 6162 28 volume volume NN cord-010092-uftc8inx 6162 29 and and CC cord-010092-uftc8inx 6162 30 residual residual JJ cord-010092-uftc8inx 6162 31 platelet platelet NN cord-010092-uftc8inx 6162 32 content content NN cord-010092-uftc8inx 6162 33 ; ; : cord-010092-uftc8inx 6162 34 and and CC cord-010092-uftc8inx 6162 35 PCs pc NNS cord-010092-uftc8inx 6162 36 : : : cord-010092-uftc8inx 6162 37 volume volume NN cord-010092-uftc8inx 6162 38 and and CC cord-010092-uftc8inx 6162 39 yield yield NN cord-010092-uftc8inx 6162 40 , , , cord-010092-uftc8inx 6162 41 were be VBD cord-010092-uftc8inx 6162 42 analyzed analyze VBN cord-010092-uftc8inx 6162 43 . . . cord-010092-uftc8inx 6163 1 A a DT cord-010092-uftc8inx 6163 2 control control NN cord-010092-uftc8inx 6163 3 group group NN cord-010092-uftc8inx 6163 4 consisting consist VBG cord-010092-uftc8inx 6163 5 of of IN cord-010092-uftc8inx 6163 6 units unit NNS cord-010092-uftc8inx 6163 7 processed process VBN cord-010092-uftc8inx 6163 8 with with IN cord-010092-uftc8inx 6163 9 a a DT cord-010092-uftc8inx 6163 10 semiautomated semiautomated JJ cord-010092-uftc8inx 6163 11 platform platform NN cord-010092-uftc8inx 6163 12 was be VBD cord-010092-uftc8inx 6163 13 used use VBN cord-010092-uftc8inx 6163 14 as as IN cord-010092-uftc8inx 6163 15 comparison comparison NN cord-010092-uftc8inx 6163 16 . . . cord-010092-uftc8inx 6164 1 A a DT cord-010092-uftc8inx 6164 2 survey survey NN cord-010092-uftc8inx 6164 3 was be VBD cord-010092-uftc8inx 6164 4 sent send VBN cord-010092-uftc8inx 6164 5 to to IN cord-010092-uftc8inx 6164 6 the the DT cord-010092-uftc8inx 6164 7 collection collection NN cord-010092-uftc8inx 6164 8 and and CC cord-010092-uftc8inx 6164 9 processing processing NN cord-010092-uftc8inx 6164 10 staff staff NN cord-010092-uftc8inx 6164 11 for for IN cord-010092-uftc8inx 6164 12 feedback feedback NN cord-010092-uftc8inx 6164 13 on on IN cord-010092-uftc8inx 6164 14 operational operational JJ cord-010092-uftc8inx 6164 15 aspects aspect NNS cord-010092-uftc8inx 6164 16 of of IN cord-010092-uftc8inx 6164 17 the the DT cord-010092-uftc8inx 6164 18 use use NN cord-010092-uftc8inx 6164 19 of of IN cord-010092-uftc8inx 6164 20 Reveos Reveos NNP cord-010092-uftc8inx 6164 21 . . . cord-010092-uftc8inx 6165 1 From from IN cord-010092-uftc8inx 6165 2 2013 2013 CD cord-010092-uftc8inx 6165 3 to to IN cord-010092-uftc8inx 6165 4 2018 2018 CD cord-010092-uftc8inx 6165 5 , , , cord-010092-uftc8inx 6165 6 QC QC NNP cord-010092-uftc8inx 6165 7 data datum NNS cord-010092-uftc8inx 6165 8 of of IN cord-010092-uftc8inx 6165 9 RCCs RCCs NNP cord-010092-uftc8inx 6165 10 ( ( -LRB- cord-010092-uftc8inx 6165 11 n n NN cord-010092-uftc8inx 6165 12 = = SYM cord-010092-uftc8inx 6165 13 3025 3025 CD cord-010092-uftc8inx 6165 14 ) ) -RRB- cord-010092-uftc8inx 6165 15 , , , cord-010092-uftc8inx 6165 16 plasma plasma NN cord-010092-uftc8inx 6165 17 ( ( -LRB- cord-010092-uftc8inx 6165 18 n n NN cord-010092-uftc8inx 6165 19 = = SYM cord-010092-uftc8inx 6165 20 660 660 CD cord-010092-uftc8inx 6165 21 ) ) -RRB- cord-010092-uftc8inx 6165 22 and and CC cord-010092-uftc8inx 6165 23 PCs pc NNS cord-010092-uftc8inx 6165 24 ( ( -LRB- cord-010092-uftc8inx 6165 25 n n NN cord-010092-uftc8inx 6165 26 = = SYM cord-010092-uftc8inx 6165 27 660 660 CD cord-010092-uftc8inx 6165 28 ) ) -RRB- cord-010092-uftc8inx 6165 29 processed process VBN cord-010092-uftc8inx 6165 30 with with IN cord-010092-uftc8inx 6165 31 Reveos Reveos NNP cord-010092-uftc8inx 6165 32 were be VBD cord-010092-uftc8inx 6165 33 collected collect VBN cord-010092-uftc8inx 6165 34 . . . cord-010092-uftc8inx 6166 1 Number number NN cord-010092-uftc8inx 6166 2 of of IN cord-010092-uftc8inx 6166 3 Mirasol Mirasol NNP cord-010092-uftc8inx 6166 4 treated treat VBD cord-010092-uftc8inx 6166 5 PCs pc NNS cord-010092-uftc8inx 6166 6 and and CC cord-010092-uftc8inx 6166 7 hemovigilance hemovigilance NN cord-010092-uftc8inx 6166 8 data datum NNS cord-010092-uftc8inx 6166 9 from from IN cord-010092-uftc8inx 6166 10 2015 2015 CD cord-010092-uftc8inx 6166 11 to to IN cord-010092-uftc8inx 6166 12 2018 2018 CD cord-010092-uftc8inx 6166 13 were be VBD cord-010092-uftc8inx 6166 14 collected collect VBN cord-010092-uftc8inx 6166 15 . . . cord-010092-uftc8inx 6167 1 Results result NNS cord-010092-uftc8inx 6167 2 : : : cord-010092-uftc8inx 6167 3 Volume volume NN cord-010092-uftc8inx 6167 4 , , , cord-010092-uftc8inx 6167 5 Hb Hb NNP cord-010092-uftc8inx 6167 6 and and CC cord-010092-uftc8inx 6167 7 Hct Hct NNP cord-010092-uftc8inx 6167 8 of of IN cord-010092-uftc8inx 6167 9 RCCs rcc NNS cord-010092-uftc8inx 6167 10 processed process VBN cord-010092-uftc8inx 6167 11 with with IN cord-010092-uftc8inx 6167 12 Reveos Reveos NNP cord-010092-uftc8inx 6167 13 were be VBD cord-010092-uftc8inx 6167 14 significantly significantly RB cord-010092-uftc8inx 6167 15 higher high JJR cord-010092-uftc8inx 6167 16 compared compare VBN cord-010092-uftc8inx 6167 17 to to IN cord-010092-uftc8inx 6167 18 control control NN cord-010092-uftc8inx 6167 19 RCCs RCCs . cord-010092-uftc8inx 6167 20 ( ( -LRB- cord-010092-uftc8inx 6167 21 Volume volume NN cord-010092-uftc8inx 6167 22 : : : cord-010092-uftc8inx 6167 23 296 296 CD cord-010092-uftc8inx 6167 24 AE AE NNP cord-010092-uftc8inx 6167 25 21 21 CD cord-010092-uftc8inx 6167 26 ml ml NNS cord-010092-uftc8inx 6167 27 vs vs IN cord-010092-uftc8inx 6167 28 251 251 CD cord-010092-uftc8inx 6167 29 AE AE NNP cord-010092-uftc8inx 6167 30 19 19 CD cord-010092-uftc8inx 6167 31 ml ml NNS cord-010092-uftc8inx 6167 32 ; ; : cord-010092-uftc8inx 6167 33 Hb Hb NNP cord-010092-uftc8inx 6167 34 : : : cord-010092-uftc8inx 6167 35 59.9 59.9 CD cord-010092-uftc8inx 6167 36 AE AE NNP cord-010092-uftc8inx 6167 37 6.2 6.2 CD cord-010092-uftc8inx 6167 38 g/ g/ JJ cord-010092-uftc8inx 6167 39 unit unit NN cord-010092-uftc8inx 6167 40 vs vs IN cord-010092-uftc8inx 6167 41 49.2 49.2 CD cord-010092-uftc8inx 6167 42 AE AE NNP cord-010092-uftc8inx 6167 43 7.8 7.8 CD cord-010092-uftc8inx 6167 44 g g NN cord-010092-uftc8inx 6167 45 / / SYM cord-010092-uftc8inx 6167 46 unit unit NN cord-010092-uftc8inx 6167 47 ; ; : cord-010092-uftc8inx 6167 48 Hct hct NN cord-010092-uftc8inx 6167 49 : : : cord-010092-uftc8inx 6167 50 59.5 59.5 CD cord-010092-uftc8inx 6167 51 AE AE NNP cord-010092-uftc8inx 6167 52 2.7 2.7 CD cord-010092-uftc8inx 6167 53 % % NN cord-010092-uftc8inx 6167 54 vs vs IN cord-010092-uftc8inx 6167 55 56.1 56.1 CD cord-010092-uftc8inx 6167 56 AE AE NNP cord-010092-uftc8inx 6167 57 6.3 6.3 CD cord-010092-uftc8inx 6167 58 % % NN cord-010092-uftc8inx 6167 59 ) ) -RRB- cord-010092-uftc8inx 6167 60 . . . cord-010092-uftc8inx 6168 1 Control control NN cord-010092-uftc8inx 6168 2 plasma plasma NN cord-010092-uftc8inx 6168 3 units unit NNS cord-010092-uftc8inx 6168 4 had have VBD cord-010092-uftc8inx 6168 5 higher high JJR cord-010092-uftc8inx 6168 6 volume volume NN cord-010092-uftc8inx 6168 7 ( ( -LRB- cord-010092-uftc8inx 6168 8 280 280 CD cord-010092-uftc8inx 6168 9 AE AE NNP cord-010092-uftc8inx 6168 10 17 17 CD cord-010092-uftc8inx 6168 11 ml ml NNS cord-010092-uftc8inx 6168 12 ) ) -RRB- cord-010092-uftc8inx 6168 13 and and CC cord-010092-uftc8inx 6168 14 lower low JJR cord-010092-uftc8inx 6168 15 residual residual JJ cord-010092-uftc8inx 6168 16 platelet platelet NN cord-010092-uftc8inx 6168 17 content content NN cord-010092-uftc8inx 6168 18 ( ( -LRB- cord-010092-uftc8inx 6168 19 9 9 CD cord-010092-uftc8inx 6168 20 AE AE NNP cord-010092-uftc8inx 6168 21 7 7 CD cord-010092-uftc8inx 6168 22 10 10 CD cord-010092-uftc8inx 6168 23 9 9 CD cord-010092-uftc8inx 6168 24 /l /l NN cord-010092-uftc8inx 6168 25 ) ) -RRB- cord-010092-uftc8inx 6168 26 compared compare VBN cord-010092-uftc8inx 6168 27 to to IN cord-010092-uftc8inx 6168 28 Reveos Reveos NNP cord-010092-uftc8inx 6168 29 plasma plasma NN cord-010092-uftc8inx 6168 30 units unit NNS cord-010092-uftc8inx 6168 31 ( ( -LRB- cord-010092-uftc8inx 6168 32 volume volume NN cord-010092-uftc8inx 6168 33 : : : cord-010092-uftc8inx 6168 34 249 249 CD cord-010092-uftc8inx 6168 35 AE AE NNP cord-010092-uftc8inx 6168 36 23 23 CD cord-010092-uftc8inx 6168 37 ml ml NNS cord-010092-uftc8inx 6168 38 ; ; : cord-010092-uftc8inx 6168 39 residual residual JJ cord-010092-uftc8inx 6168 40 platelet platelet NN cord-010092-uftc8inx 6168 41 content content NN cord-010092-uftc8inx 6168 42 19 19 CD cord-010092-uftc8inx 6168 43 AE AE NNP cord-010092-uftc8inx 6168 44 13 13 CD cord-010092-uftc8inx 6168 45 10 10 CD cord-010092-uftc8inx 6168 46 9 9 CD cord-010092-uftc8inx 6168 47 /l /l NN cord-010092-uftc8inx 6168 48 ) ) -RRB- cord-010092-uftc8inx 6168 49 . . . cord-010092-uftc8inx 6169 1 For for IN cord-010092-uftc8inx 6169 2 PCs pc NNS cord-010092-uftc8inx 6169 3 , , , cord-010092-uftc8inx 6169 4 volume volume NN cord-010092-uftc8inx 6169 5 was be VBD cord-010092-uftc8inx 6169 6 higher high JJR cord-010092-uftc8inx 6169 7 for for IN cord-010092-uftc8inx 6169 8 units unit NNS cord-010092-uftc8inx 6169 9 processed process VBN cord-010092-uftc8inx 6169 10 with with IN cord-010092-uftc8inx 6169 11 Reveos Reveos NNP cord-010092-uftc8inx 6169 12 compared compare VBN cord-010092-uftc8inx 6169 13 to to IN cord-010092-uftc8inx 6169 14 control control NN cord-010092-uftc8inx 6169 15 ( ( -LRB- cord-010092-uftc8inx 6169 16 350 350 CD cord-010092-uftc8inx 6169 17 AE AE NNP cord-010092-uftc8inx 6169 18 20 20 CD cord-010092-uftc8inx 6169 19 ml ml NNS cord-010092-uftc8inx 6169 20 vs vs IN cord-010092-uftc8inx 6169 21 310 310 CD cord-010092-uftc8inx 6169 22 AE AE NNP cord-010092-uftc8inx 6169 23 10 10 CD cord-010092-uftc8inx 6169 24 ) ) -RRB- cord-010092-uftc8inx 6169 25 , , , cord-010092-uftc8inx 6169 26 but but CC cord-010092-uftc8inx 6169 27 no no DT cord-010092-uftc8inx 6169 28 statistical statistical JJ cord-010092-uftc8inx 6169 29 difference difference NN cord-010092-uftc8inx 6169 30 was be VBD cord-010092-uftc8inx 6169 31 observed observe VBN cord-010092-uftc8inx 6169 32 in in IN cord-010092-uftc8inx 6169 33 platelet platelet NN cord-010092-uftc8inx 6169 34 content content NN cord-010092-uftc8inx 6170 1 ( ( -LRB- cord-010092-uftc8inx 6170 2 Reveos Reveos NNP cord-010092-uftc8inx 6170 3 : : : cord-010092-uftc8inx 6170 4 361 361 CD cord-010092-uftc8inx 6170 5 AE AE NNP cord-010092-uftc8inx 6170 6 60 60 CD cord-010092-uftc8inx 6170 7 9 9 CD cord-010092-uftc8inx 6170 8 10 10 CD cord-010092-uftc8inx 6170 9 9 9 CD cord-010092-uftc8inx 6170 10 /unit /unit , cord-010092-uftc8inx 6170 11 ; ; : cord-010092-uftc8inx 6170 12 Control control NN cord-010092-uftc8inx 6170 13 : : : cord-010092-uftc8inx 6170 14 386 386 CD cord-010092-uftc8inx 6170 15 AE AE NNP cord-010092-uftc8inx 6170 16 80.10 80.10 CD cord-010092-uftc8inx 6170 17 9 9 CD cord-010092-uftc8inx 6170 18 /unit /unit . cord-010092-uftc8inx 6170 19 ) ) -RRB- cord-010092-uftc8inx 6170 20 . . . cord-010092-uftc8inx 6171 1 We -PRON- PRP cord-010092-uftc8inx 6171 2 observed observe VBD cord-010092-uftc8inx 6171 3 either either CC cord-010092-uftc8inx 6171 4 an an DT cord-010092-uftc8inx 6171 5 increase increase NN cord-010092-uftc8inx 6171 6 or or CC cord-010092-uftc8inx 6171 7 stabilization stabilization NN cord-010092-uftc8inx 6171 8 in in IN cord-010092-uftc8inx 6171 9 QC QC NNP cord-010092-uftc8inx 6171 10 parameters parameter NNS cord-010092-uftc8inx 6171 11 of of IN cord-010092-uftc8inx 6171 12 RCCs rccs NN cord-010092-uftc8inx 6171 13 , , , cord-010092-uftc8inx 6171 14 plasma plasma NN cord-010092-uftc8inx 6171 15 and and CC cord-010092-uftc8inx 6171 16 PCs pc NNS cord-010092-uftc8inx 6171 17 during during IN cord-010092-uftc8inx 6171 18 the the DT cord-010092-uftc8inx 6171 19 5 5 CD cord-010092-uftc8inx 6171 20 years year NNS cord-010092-uftc8inx 6171 21 routine routine JJ cord-010092-uftc8inx 6171 22 use use NN cord-010092-uftc8inx 6171 23 of of IN cord-010092-uftc8inx 6171 24 Reveos Reveos NNP cord-010092-uftc8inx 6171 25 . . . cord-010092-uftc8inx 6172 1 For for IN cord-010092-uftc8inx 6172 2 example example NN cord-010092-uftc8inx 6172 3 , , , cord-010092-uftc8inx 6172 4 percentage percentage NN cord-010092-uftc8inx 6172 5 of of IN cord-010092-uftc8inx 6172 6 RCCs rccs NN cord-010092-uftc8inx 6172 7 units unit NNS cord-010092-uftc8inx 6172 8 hemolyzed hemolyze VBN cord-010092-uftc8inx 6172 9 dropped drop VBD cord-010092-uftc8inx 6172 10 from from IN cord-010092-uftc8inx 6172 11 4 4 CD cord-010092-uftc8inx 6172 12 % % NN cord-010092-uftc8inx 6172 13 to to IN cord-010092-uftc8inx 6172 14 0 0 CD cord-010092-uftc8inx 6172 15 % % NN cord-010092-uftc8inx 6172 16 between between IN cord-010092-uftc8inx 6172 17 2013 2013 CD cord-010092-uftc8inx 6172 18 and and CC cord-010092-uftc8inx 6172 19 2018 2018 CD cord-010092-uftc8inx 6172 20 and and CC cord-010092-uftc8inx 6172 21 platelet platelet NN cord-010092-uftc8inx 6172 22 content content NN cord-010092-uftc8inx 6172 23 in in IN cord-010092-uftc8inx 6172 24 PCs pc NNS cord-010092-uftc8inx 6172 25 increased increase VBD cord-010092-uftc8inx 6172 26 from from IN cord-010092-uftc8inx 6172 27 370 370 CD cord-010092-uftc8inx 6172 28 9 9 CD cord-010092-uftc8inx 6172 29 10 10 CD cord-010092-uftc8inx 6172 30 9 9 CD cord-010092-uftc8inx 6172 31 /unit /unit . cord-010092-uftc8inx 6172 32 ( ( -LRB- cord-010092-uftc8inx 6172 33 first first JJ cord-010092-uftc8inx 6172 34 six six CD cord-010092-uftc8inx 6172 35 months month NNS cord-010092-uftc8inx 6172 36 in in IN cord-010092-uftc8inx 6172 37 routine routine NN cord-010092-uftc8inx 6172 38 ) ) -RRB- cord-010092-uftc8inx 6172 39 to to IN cord-010092-uftc8inx 6172 40 390 390 CD cord-010092-uftc8inx 6172 41 9 9 CD cord-010092-uftc8inx 6172 42 10 10 CD cord-010092-uftc8inx 6172 43 9 9 CD cord-010092-uftc8inx 6172 44 /unit /unit . cord-010092-uftc8inx 6172 45 . . . cord-010092-uftc8inx 6173 1 Plasma plasma NN cord-010092-uftc8inx 6173 2 volume volume NN cord-010092-uftc8inx 6173 3 increased increase VBD cord-010092-uftc8inx 6173 4 from from IN cord-010092-uftc8inx 6173 5 249 249 CD cord-010092-uftc8inx 6173 6 ml ml NNS cord-010092-uftc8inx 6173 7 during during IN cord-010092-uftc8inx 6173 8 validation validation NN cord-010092-uftc8inx 6173 9 to to IN cord-010092-uftc8inx 6173 10 267 267 CD cord-010092-uftc8inx 6173 11 ml ml NNS cord-010092-uftc8inx 6173 12 in in IN cord-010092-uftc8inx 6173 13 2018 2018 CD cord-010092-uftc8inx 6173 14 . . . cord-010092-uftc8inx 6174 1 Survey survey NN cord-010092-uftc8inx 6174 2 results result VBZ cord-010092-uftc8inx 6174 3 from from IN cord-010092-uftc8inx 6174 4 staff staff NN cord-010092-uftc8inx 6174 5 highlighted highlight VBD cord-010092-uftc8inx 6174 6 the the DT cord-010092-uftc8inx 6174 7 user user NN cord-010092-uftc8inx 6174 8 friendliness friendliness NN cord-010092-uftc8inx 6174 9 of of IN cord-010092-uftc8inx 6174 10 the the DT cord-010092-uftc8inx 6174 11 Reveos Reveos NNP cord-010092-uftc8inx 6174 12 device device NN cord-010092-uftc8inx 6174 13 . . . cord-010092-uftc8inx 6175 1 Number number NN cord-010092-uftc8inx 6175 2 of of IN cord-010092-uftc8inx 6175 3 Mirasol Mirasol NNP cord-010092-uftc8inx 6175 4 treated treat VBD cord-010092-uftc8inx 6175 5 PCs pc NNS cord-010092-uftc8inx 6175 6 increased increase VBD cord-010092-uftc8inx 6175 7 from from IN cord-010092-uftc8inx 6175 8 10 10 CD cord-010092-uftc8inx 6175 9 % % NN cord-010092-uftc8inx 6175 10 in in IN cord-010092-uftc8inx 6175 11 2015 2015 CD cord-010092-uftc8inx 6175 12 to to IN cord-010092-uftc8inx 6175 13 59.7 59.7 CD cord-010092-uftc8inx 6175 14 % % NN cord-010092-uftc8inx 6175 15 in in IN cord-010092-uftc8inx 6175 16 2018 2018 CD cord-010092-uftc8inx 6175 17 with with IN cord-010092-uftc8inx 6175 18 no no DT cord-010092-uftc8inx 6175 19 pathogen pathogen NN cord-010092-uftc8inx 6175 20 transmission transmission NN cord-010092-uftc8inx 6175 21 nor nor CC cord-010092-uftc8inx 6175 22 serious serious JJ cord-010092-uftc8inx 6175 23 adverse adverse JJ cord-010092-uftc8inx 6175 24 events event NNS cord-010092-uftc8inx 6175 25 reported report VBD cord-010092-uftc8inx 6175 26 following follow VBG cord-010092-uftc8inx 6175 27 transfusion transfusion NN cord-010092-uftc8inx 6175 28 of of IN cord-010092-uftc8inx 6175 29 these these DT cord-010092-uftc8inx 6175 30 products product NNS cord-010092-uftc8inx 6175 31 . . . cord-010092-uftc8inx 6176 1 Summary Summary NNP cord-010092-uftc8inx 6176 2 / / SYM cord-010092-uftc8inx 6176 3 Conclusions conclusion NNS cord-010092-uftc8inx 6176 4 : : : cord-010092-uftc8inx 6176 5 With with IN cord-010092-uftc8inx 6176 6 implementation implementation NN cord-010092-uftc8inx 6176 7 of of IN cord-010092-uftc8inx 6176 8 two two CD cord-010092-uftc8inx 6176 9 user user NN cord-010092-uftc8inx 6176 10 - - HYPH cord-010092-uftc8inx 6176 11 friendly friendly JJ cord-010092-uftc8inx 6176 12 systems system NNS cord-010092-uftc8inx 6176 13 , , , cord-010092-uftc8inx 6176 14 the the DT cord-010092-uftc8inx 6176 15 Reveos Reveos NNP cord-010092-uftc8inx 6176 16 whole whole JJ cord-010092-uftc8inx 6176 17 blood blood NN cord-010092-uftc8inx 6176 18 automation automation NN cord-010092-uftc8inx 6176 19 system system NN cord-010092-uftc8inx 6176 20 and and CC cord-010092-uftc8inx 6176 21 Mirasol Mirasol NNP cord-010092-uftc8inx 6176 22 PRT PRT NNP cord-010092-uftc8inx 6176 23 system system NN cord-010092-uftc8inx 6176 24 , , , cord-010092-uftc8inx 6176 25 we -PRON- PRP cord-010092-uftc8inx 6176 26 observed observe VBD cord-010092-uftc8inx 6176 27 an an DT cord-010092-uftc8inx 6176 28 increased increase VBN cord-010092-uftc8inx 6176 29 standardization standardization NN cord-010092-uftc8inx 6176 30 of of IN cord-010092-uftc8inx 6176 31 our -PRON- PRP$ cord-010092-uftc8inx 6176 32 processes process NNS cord-010092-uftc8inx 6176 33 enabling enable VBG cord-010092-uftc8inx 6176 34 us -PRON- PRP cord-010092-uftc8inx 6176 35 to to TO cord-010092-uftc8inx 6176 36 provide provide VB cord-010092-uftc8inx 6176 37 higher high JJR cord-010092-uftc8inx 6176 38 quality quality NN cord-010092-uftc8inx 6176 39 and and CC cord-010092-uftc8inx 6176 40 safer safe JJR cord-010092-uftc8inx 6176 41 blood blood NN cord-010092-uftc8inx 6176 42 products product NNS cord-010092-uftc8inx 6176 43 to to IN cord-010092-uftc8inx 6176 44 hospitals hospital NNS cord-010092-uftc8inx 6176 45 and and CC cord-010092-uftc8inx 6176 46 the the DT cord-010092-uftc8inx 6176 47 patients patient NNS cord-010092-uftc8inx 6176 48 they -PRON- PRP cord-010092-uftc8inx 6176 49 serve serve VBP cord-010092-uftc8inx 6176 50 . . . cord-010092-uftc8inx 6177 1 Background background NN cord-010092-uftc8inx 6177 2 : : : cord-010092-uftc8inx 6178 1 White white JJ cord-010092-uftc8inx 6178 2 blood blood NN cord-010092-uftc8inx 6178 3 cells cell NNS cord-010092-uftc8inx 6178 4 ( ( -LRB- cord-010092-uftc8inx 6178 5 WBC WBC NNP cord-010092-uftc8inx 6178 6 ) ) -RRB- cord-010092-uftc8inx 6178 7 may may MD cord-010092-uftc8inx 6178 8 be be VB cord-010092-uftc8inx 6178 9 regarded regard VBN cord-010092-uftc8inx 6178 10 as as IN cord-010092-uftc8inx 6178 11 contaminants contaminant NNS cord-010092-uftc8inx 6178 12 in in IN cord-010092-uftc8inx 6178 13 blood blood NN cord-010092-uftc8inx 6178 14 components component NNS cord-010092-uftc8inx 6178 15 and and CC cord-010092-uftc8inx 6178 16 potentially potentially RB cord-010092-uftc8inx 6178 17 reduce reduce VB cord-010092-uftc8inx 6178 18 transfusion transfusion NN cord-010092-uftc8inx 6178 19 safety safety NN cord-010092-uftc8inx 6178 20 . . . cord-010092-uftc8inx 6179 1 There there EX cord-010092-uftc8inx 6179 2 is be VBZ cord-010092-uftc8inx 6179 3 currently currently RB cord-010092-uftc8inx 6179 4 enough enough JJ cord-010092-uftc8inx 6179 5 evidence evidence NN cord-010092-uftc8inx 6179 6 showing show VBG cord-010092-uftc8inx 6179 7 that that IN cord-010092-uftc8inx 6179 8 WBC WBC NNP cord-010092-uftc8inx 6179 9 reduction reduction NN cord-010092-uftc8inx 6179 10 through through IN cord-010092-uftc8inx 6179 11 pre pre JJ cord-010092-uftc8inx 6179 12 - - JJ cord-010092-uftc8inx 6179 13 storage storage JJ cord-010092-uftc8inx 6179 14 filtration filtration NN cord-010092-uftc8inx 6179 15 reduces reduce VBZ cord-010092-uftc8inx 6179 16 the the DT cord-010092-uftc8inx 6179 17 incidence incidence NN cord-010092-uftc8inx 6179 18 of of IN cord-010092-uftc8inx 6179 19 three three CD cord-010092-uftc8inx 6179 20 major major JJ cord-010092-uftc8inx 6179 21 complications complication NNS cord-010092-uftc8inx 6179 22 of of IN cord-010092-uftc8inx 6179 23 allogeneic allogeneic NN cord-010092-uftc8inx 6179 24 blood blood NN cord-010092-uftc8inx 6179 25 transfusions transfusion NNS cord-010092-uftc8inx 6179 26 : : : cord-010092-uftc8inx 6179 27 febrile febrile JJ cord-010092-uftc8inx 6179 28 nonhemolytic nonhemolytic JJ cord-010092-uftc8inx 6179 29 transfusion transfusion NN cord-010092-uftc8inx 6179 30 reactions reaction NNS cord-010092-uftc8inx 6179 31 ( ( -LRB- cord-010092-uftc8inx 6179 32 FNHTR FNHTR NNP cord-010092-uftc8inx 6179 33 ) ) -RRB- cord-010092-uftc8inx 6179 34 , , , cord-010092-uftc8inx 6179 35 refractoriness refractoriness VBP cord-010092-uftc8inx 6179 36 to to IN cord-010092-uftc8inx 6179 37 random random JJ cord-010092-uftc8inx 6179 38 - - HYPH cord-010092-uftc8inx 6179 39 donor donor NN cord-010092-uftc8inx 6179 40 platelet platelet NN cord-010092-uftc8inx 6179 41 transfusions transfusion NNS cord-010092-uftc8inx 6179 42 and and CC cord-010092-uftc8inx 6179 43 transmission transmission NN cord-010092-uftc8inx 6179 44 of of IN cord-010092-uftc8inx 6179 45 CMV CMV NNP cord-010092-uftc8inx 6179 46 . . . cord-010092-uftc8inx 6180 1 Leukodepletion leukodepletion NN cord-010092-uftc8inx 6180 2 is be VBZ cord-010092-uftc8inx 6180 3 now now RB cord-010092-uftc8inx 6180 4 mandatory mandatory JJ cord-010092-uftc8inx 6180 5 in in IN cord-010092-uftc8inx 6180 6 Canada Canada NNP cord-010092-uftc8inx 6180 7 and and CC cord-010092-uftc8inx 6180 8 several several JJ cord-010092-uftc8inx 6180 9 European european JJ cord-010092-uftc8inx 6180 10 countries country NNS cord-010092-uftc8inx 6180 11 . . . cord-010092-uftc8inx 6181 1 Aims aim VBZ cord-010092-uftc8inx 6181 2 : : : cord-010092-uftc8inx 6182 1 The the DT cord-010092-uftc8inx 6182 2 aim aim NN cord-010092-uftc8inx 6182 3 of of IN cord-010092-uftc8inx 6182 4 this this DT cord-010092-uftc8inx 6182 5 study study NN cord-010092-uftc8inx 6182 6 was be VBD cord-010092-uftc8inx 6182 7 to to TO cord-010092-uftc8inx 6182 8 evaluate evaluate VB cord-010092-uftc8inx 6182 9 leukoreduction leukoreduction NN cord-010092-uftc8inx 6182 10 performance performance NN cord-010092-uftc8inx 6182 11 and and CC cord-010092-uftc8inx 6182 12 the the DT cord-010092-uftc8inx 6182 13 quality quality NN cord-010092-uftc8inx 6182 14 of of IN cord-010092-uftc8inx 6182 15 the the DT cord-010092-uftc8inx 6182 16 resulting result VBG cord-010092-uftc8inx 6182 17 red red JJ cord-010092-uftc8inx 6182 18 blood blood NN cord-010092-uftc8inx 6182 19 cell cell NN cord-010092-uftc8inx 6182 20 concentrate concentrate NN cord-010092-uftc8inx 6182 21 ( ( -LRB- cord-010092-uftc8inx 6182 22 RBC RBC NNP cord-010092-uftc8inx 6182 23 ) ) -RRB- cord-010092-uftc8inx 6182 24 produced produce VBN cord-010092-uftc8inx 6182 25 with with IN cord-010092-uftc8inx 6182 26 new new JJ cord-010092-uftc8inx 6182 27 quadruple quadruple JJ cord-010092-uftc8inx 6182 28 system system NN cord-010092-uftc8inx 6182 29 Top Top NNP cord-010092-uftc8inx 6182 30 & & CC cord-010092-uftc8inx 6182 31 Bottom Bottom NNP cord-010092-uftc8inx 6182 32 IMUFLEX IMUFLEX NNP cord-010092-uftc8inx 6182 33 CRC CRC NNP cord-010092-uftc8inx 6182 34 with with IN cord-010092-uftc8inx 6182 35 an an DT cord-010092-uftc8inx 6182 36 integrated integrated JJ cord-010092-uftc8inx 6182 37 Red Red NNP cord-010092-uftc8inx 6182 38 Blood Blood NNP cord-010092-uftc8inx 6182 39 Cells Cells NNP cord-010092-uftc8inx 6182 40 filter filter NN cord-010092-uftc8inx 6182 41 which which WDT cord-010092-uftc8inx 6182 42 was be VBD cord-010092-uftc8inx 6182 43 used use VBN cord-010092-uftc8inx 6182 44 in in IN cord-010092-uftc8inx 6182 45 whole whole JJ cord-010092-uftc8inx 6182 46 blood blood NN cord-010092-uftc8inx 6182 47 fractionation fractionation NN cord-010092-uftc8inx 6182 48 under under IN cord-010092-uftc8inx 6182 49 routine routine JJ cord-010092-uftc8inx 6182 50 conditions condition NNS cord-010092-uftc8inx 6182 51 of of IN cord-010092-uftc8inx 6182 52 San San NNP cord-010092-uftc8inx 6182 53 Paolo Paolo NNP cord-010092-uftc8inx 6182 54 Asl Asl NNP cord-010092-uftc8inx 6182 55 blood blood NN cord-010092-uftc8inx 6182 56 bank bank NN cord-010092-uftc8inx 6182 57 Methods method NNS cord-010092-uftc8inx 6182 58 : : : cord-010092-uftc8inx 6183 1 Twenty twenty CD cord-010092-uftc8inx 6183 2 - - HYPH cord-010092-uftc8inx 6183 3 seven seven CD cord-010092-uftc8inx 6183 4 whole whole JJ cord-010092-uftc8inx 6183 5 blood blood NN cord-010092-uftc8inx 6183 6 donations donation NNS cord-010092-uftc8inx 6183 7 ( ( -LRB- cord-010092-uftc8inx 6183 8 450 450 CD cord-010092-uftc8inx 6183 9 ml ml NNS cord-010092-uftc8inx 6183 10 ) ) -RRB- cord-010092-uftc8inx 6183 11 were be VBD cord-010092-uftc8inx 6183 12 collected collect VBN cord-010092-uftc8inx 6183 13 with with IN cord-010092-uftc8inx 6183 14 using use VBG cord-010092-uftc8inx 6183 15 quadruple quadruple JJ cord-010092-uftc8inx 6183 16 blood blood NN cord-010092-uftc8inx 6183 17 bags bag NNS cord-010092-uftc8inx 6183 18 Top top JJ cord-010092-uftc8inx 6183 19 & & CC cord-010092-uftc8inx 6183 20 Bottom Bottom NNP cord-010092-uftc8inx 6183 21 system system NN cord-010092-uftc8inx 6183 22 with with IN cord-010092-uftc8inx 6183 23 an an DT cord-010092-uftc8inx 6183 24 integrated integrate VBN cord-010092-uftc8inx 6183 25 RBC RBC NNP cord-010092-uftc8inx 6183 26 filter filter NN cord-010092-uftc8inx 6183 27 ( ( -LRB- cord-010092-uftc8inx 6183 28 IMUFLEX IMUFLEX NNP cord-010092-uftc8inx 6183 29 CRC CRC NNP cord-010092-uftc8inx 6183 30 , , , cord-010092-uftc8inx 6183 31 Terumo Terumo NNP cord-010092-uftc8inx 6183 32 BCT BCT NNP cord-010092-uftc8inx 6183 33 ) ) -RRB- cord-010092-uftc8inx 6183 34 . . . cord-010092-uftc8inx 6184 1 Centrifugation Centrifugation NNP cord-010092-uftc8inx 6184 2 and and CC cord-010092-uftc8inx 6184 3 processing processing NN cord-010092-uftc8inx 6184 4 ( ( -LRB- cord-010092-uftc8inx 6184 5 using use VBG cord-010092-uftc8inx 6184 6 T T NNP cord-010092-uftc8inx 6184 7 - - HYPH cord-010092-uftc8inx 6184 8 ACE ace NN cord-010092-uftc8inx 6184 9 II ii NN cord-010092-uftc8inx 6185 1 + + CC cord-010092-uftc8inx 6185 2 -Terumo -Terumo . cord-010092-uftc8inx 6185 3 BCT BCT NNP cord-010092-uftc8inx 6185 4 ) ) -RRB- cord-010092-uftc8inx 6185 5 of of IN cord-010092-uftc8inx 6185 6 whole whole JJ cord-010092-uftc8inx 6185 7 blood blood NN cord-010092-uftc8inx 6185 8 units unit NNS cord-010092-uftc8inx 6185 9 followed follow VBD cord-010092-uftc8inx 6185 10 the the DT cord-010092-uftc8inx 6185 11 blood blood NN cord-010092-uftc8inx 6185 12 bank bank NN cord-010092-uftc8inx 6185 13 SOP sop NN cord-010092-uftc8inx 6185 14 to to TO cord-010092-uftc8inx 6185 15 obtain obtain VB cord-010092-uftc8inx 6185 16 RBCs rbc NNS cord-010092-uftc8inx 6185 17 , , , cord-010092-uftc8inx 6185 18 Plasma Plasma NNP cord-010092-uftc8inx 6185 19 and and CC cord-010092-uftc8inx 6185 20 Buffy Buffy NNP cord-010092-uftc8inx 6185 21 Coat Coat NNP cord-010092-uftc8inx 6185 22 . . . cord-010092-uftc8inx 6186 1 RBCs rbc NNS cord-010092-uftc8inx 6186 2 were be VBD cord-010092-uftc8inx 6186 3 diluted dilute VBN cord-010092-uftc8inx 6186 4 with with IN cord-010092-uftc8inx 6186 5 SAGM SAGM NNP cord-010092-uftc8inx 6186 6 ( ( -LRB- cord-010092-uftc8inx 6186 7 100 100 CD cord-010092-uftc8inx 6186 8 ml ml NNS cord-010092-uftc8inx 6186 9 ) ) -RRB- cord-010092-uftc8inx 6186 10 and and CC cord-010092-uftc8inx 6186 11 then then RB cord-010092-uftc8inx 6186 12 filtered filter VBN cord-010092-uftc8inx 6186 13 by by IN cord-010092-uftc8inx 6186 14 gravity gravity NN cord-010092-uftc8inx 6186 15 in in IN cord-010092-uftc8inx 6186 16 average average JJ cord-010092-uftc8inx 6186 17 2 2 CD cord-010092-uftc8inx 6186 18 - - SYM cord-010092-uftc8inx 6186 19 3 3 CD cord-010092-uftc8inx 6186 20 h h NN cord-010092-uftc8inx 6186 21 after after IN cord-010092-uftc8inx 6186 22 blood blood NN cord-010092-uftc8inx 6186 23 collection collection NN cord-010092-uftc8inx 6186 24 to to TO cord-010092-uftc8inx 6186 25 obtain obtain VB cord-010092-uftc8inx 6186 26 leukoreduced leukoreduce VBN cord-010092-uftc8inx 6186 27 RBC RBC NNP cord-010092-uftc8inx 6186 28 . . . cord-010092-uftc8inx 6187 1 Average average JJ cord-010092-uftc8inx 6187 2 temperature temperature NN cord-010092-uftc8inx 6187 3 during during IN cord-010092-uftc8inx 6187 4 filtration filtration NN cord-010092-uftc8inx 6187 5 was be VBD cord-010092-uftc8inx 6187 6 26 26 CD cord-010092-uftc8inx 6187 7 ° ° NN cord-010092-uftc8inx 6187 8 C c NN cord-010092-uftc8inx 6187 9 . . . cord-010092-uftc8inx 6188 1 Samples sample NNS cord-010092-uftc8inx 6188 2 were be VBD cord-010092-uftc8inx 6188 3 collected collect VBN cord-010092-uftc8inx 6188 4 before before RB cord-010092-uftc8inx 6188 5 and and CC cord-010092-uftc8inx 6188 6 after after IN cord-010092-uftc8inx 6188 7 leukoreduction leukoreduction NN cord-010092-uftc8inx 6188 8 for for IN cord-010092-uftc8inx 6188 9 calculation calculation NN cord-010092-uftc8inx 6188 10 of of IN cord-010092-uftc8inx 6188 11 hemoglobin hemoglobin NN cord-010092-uftc8inx 6188 12 loss loss NN cord-010092-uftc8inx 6188 13 through through IN cord-010092-uftc8inx 6188 14 the the DT cord-010092-uftc8inx 6188 15 filtration filtration NN cord-010092-uftc8inx 6188 16 process process NN cord-010092-uftc8inx 6188 17 . . . cord-010092-uftc8inx 6189 1 Filtration filtration NN cord-010092-uftc8inx 6189 2 time time NN cord-010092-uftc8inx 6189 3 was be VBD cord-010092-uftc8inx 6189 4 recorded record VBN cord-010092-uftc8inx 6189 5 . . . cord-010092-uftc8inx 6190 1 Final final JJ cord-010092-uftc8inx 6190 2 Hb Hb NNP cord-010092-uftc8inx 6190 3 , , , cord-010092-uftc8inx 6190 4 hematocrit hematocrit NN cord-010092-uftc8inx 6190 5 ( ( -LRB- cord-010092-uftc8inx 6190 6 Hct Hct NNP cord-010092-uftc8inx 6190 7 ) ) -RRB- cord-010092-uftc8inx 6190 8 , , , cord-010092-uftc8inx 6190 9 residual residual JJ cord-010092-uftc8inx 6190 10 platelets platelet NNS cord-010092-uftc8inx 6190 11 and and CC cord-010092-uftc8inx 6190 12 white white JJ cord-010092-uftc8inx 6190 13 blood blood NN cord-010092-uftc8inx 6190 14 cells cell NNS cord-010092-uftc8inx 6190 15 were be VBD cord-010092-uftc8inx 6190 16 determined determine VBN cord-010092-uftc8inx 6190 17 after after IN cord-010092-uftc8inx 6190 18 filtration filtration NN cord-010092-uftc8inx 6190 19 using use VBG cord-010092-uftc8inx 6190 20 standard standard JJ cord-010092-uftc8inx 6190 21 laboratory laboratory NN cord-010092-uftc8inx 6190 22 methods method NNS cord-010092-uftc8inx 6190 23 ( ( -LRB- cord-010092-uftc8inx 6190 24 blood blood NN cord-010092-uftc8inx 6190 25 cell cell NN cord-010092-uftc8inx 6190 26 counter counter NN cord-010092-uftc8inx 6190 27 ) ) -RRB- cord-010092-uftc8inx 6190 28 Results result NNS cord-010092-uftc8inx 6190 29 : : : cord-010092-uftc8inx 6190 30 WB WB NNP cord-010092-uftc8inx 6190 31 donations donation NNS cord-010092-uftc8inx 6190 32 ( ( -LRB- cord-010092-uftc8inx 6190 33 n n NN cord-010092-uftc8inx 6190 34 = = SYM cord-010092-uftc8inx 6190 35 27 27 CD cord-010092-uftc8inx 6190 36 ) ) -RRB- cord-010092-uftc8inx 6190 37 were be VBD cord-010092-uftc8inx 6190 38 performed perform VBN cord-010092-uftc8inx 6190 39 . . . cord-010092-uftc8inx 6191 1 RBC RBC NNP cord-010092-uftc8inx 6191 2 characteristics characteristic NNS cord-010092-uftc8inx 6191 3 post post NN cord-010092-uftc8inx 6191 4 - - JJ cord-010092-uftc8inx 6191 5 filtration filtration NN cord-010092-uftc8inx 6191 6 and and CC cord-010092-uftc8inx 6191 7 separation separation NN cord-010092-uftc8inx 6191 8 were be VBD cord-010092-uftc8inx 6191 9 as as IN cord-010092-uftc8inx 6191 10 follows follow VBZ cord-010092-uftc8inx 6191 11 : : : cord-010092-uftc8inx 6191 12 volume volume NN cord-010092-uftc8inx 6191 13 ( ( -LRB- cord-010092-uftc8inx 6191 14 266.8 266.8 CD cord-010092-uftc8inx 6191 15 AE AE NNP cord-010092-uftc8inx 6191 16 17.1 17.1 CD cord-010092-uftc8inx 6191 17 ml ml NNP cord-010092-uftc8inx 6191 18 ) ) -RRB- cord-010092-uftc8inx 6191 19 , , , cord-010092-uftc8inx 6191 20 hematocrit hematocrit NN cord-010092-uftc8inx 6191 21 ( ( -LRB- cord-010092-uftc8inx 6191 22 57.8 57.8 CD cord-010092-uftc8inx 6191 23 AE AE NNP cord-010092-uftc8inx 6191 24 2.1 2.1 CD cord-010092-uftc8inx 6191 25 % % NN cord-010092-uftc8inx 6191 26 ) ) -RRB- cord-010092-uftc8inx 6191 27 hemoglobin hemoglobin NN cord-010092-uftc8inx 6191 28 ( ( -LRB- cord-010092-uftc8inx 6191 29 19.8 19.8 CD cord-010092-uftc8inx 6191 30 AE AE NNP cord-010092-uftc8inx 6191 31 1.1 1.1 CD cord-010092-uftc8inx 6191 32 g g NN cord-010092-uftc8inx 6191 33 / / SYM cord-010092-uftc8inx 6191 34 dL dl NN cord-010092-uftc8inx 6191 35 ) ) -RRB- cord-010092-uftc8inx 6191 36 and and CC cord-010092-uftc8inx 6191 37 hemoglobin hemoglobin NN cord-010092-uftc8inx 6191 38 per per IN cord-010092-uftc8inx 6191 39 unit unit NN cord-010092-uftc8inx 6191 40 ( ( -LRB- cord-010092-uftc8inx 6191 41 53.0 53.0 CD cord-010092-uftc8inx 6191 42 AE AE NNP cord-010092-uftc8inx 6191 43 5.4 5.4 CD cord-010092-uftc8inx 6191 44 g g NN cord-010092-uftc8inx 6191 45 ) ) -RRB- cord-010092-uftc8inx 6191 46 ; ; , cord-010092-uftc8inx 6191 47 residual residual JJ cord-010092-uftc8inx 6191 48 platelets platelet NNS cord-010092-uftc8inx 6191 49 ( ( -LRB- cord-010092-uftc8inx 6191 50 11.7 11.7 CD cord-010092-uftc8inx 6191 51 AE AE NNP cord-010092-uftc8inx 6191 52 2.2 2.2 CD cord-010092-uftc8inx 6191 53 x10³/lL x10³/ll CD cord-010092-uftc8inx 6191 54 ) ) -RRB- cord-010092-uftc8inx 6191 55 ; ; , cord-010092-uftc8inx 6191 56 residual residual JJ cord-010092-uftc8inx 6191 57 WBCs wbc NNS cord-010092-uftc8inx 6191 58 ( ( -LRB- cord-010092-uftc8inx 6191 59 0 0 CD cord-010092-uftc8inx 6191 60 À à NN cord-010092-uftc8inx 6191 61 0.004 0.004 CD cord-010092-uftc8inx 6191 62 9 9 CD cord-010092-uftc8inx 6191 63 10³/lL 10³/ll CD cord-010092-uftc8inx 6191 64 ) ) -RRB- cord-010092-uftc8inx 6191 65 . . . cord-010092-uftc8inx 6192 1 The the DT cord-010092-uftc8inx 6192 2 mean mean JJ cord-010092-uftc8inx 6192 3 filtration filtration NN cord-010092-uftc8inx 6192 4 time time NN cord-010092-uftc8inx 6192 5 was be VBD cord-010092-uftc8inx 6192 6 19 19 CD cord-010092-uftc8inx 6192 7 AE AE NNP cord-010092-uftc8inx 6192 8 3 3 CD cord-010092-uftc8inx 6192 9 min min NN cord-010092-uftc8inx 6192 10 and and CC cord-010092-uftc8inx 6192 11 no no DT cord-010092-uftc8inx 6192 12 filter filter NN cord-010092-uftc8inx 6192 13 blocks block NNS cord-010092-uftc8inx 6192 14 were be VBD cord-010092-uftc8inx 6192 15 observed observe VBN cord-010092-uftc8inx 6193 1 Summary Summary NNP cord-010092-uftc8inx 6193 2 / / SYM cord-010092-uftc8inx 6193 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 6193 4 : : : cord-010092-uftc8inx 6194 1 The the DT cord-010092-uftc8inx 6194 2 usability usability NN cord-010092-uftc8inx 6194 3 and and CC cord-010092-uftc8inx 6194 4 performance performance NN cord-010092-uftc8inx 6194 5 of of IN cord-010092-uftc8inx 6194 6 the the DT cord-010092-uftc8inx 6194 7 new new JJ cord-010092-uftc8inx 6194 8 quadruple quadruple JJ cord-010092-uftc8inx 6194 9 system system NN cord-010092-uftc8inx 6194 10 Top Top NNP cord-010092-uftc8inx 6194 11 & & CC cord-010092-uftc8inx 6194 12 Bottom Bottom NNP cord-010092-uftc8inx 6194 13 IMUFLEX IMUFLEX NNP cord-010092-uftc8inx 6194 14 â â HYPH cord-010092-uftc8inx 6194 15 CRC CRC NNP cord-010092-uftc8inx 6194 16 with with IN cord-010092-uftc8inx 6194 17 integrated integrate VBN cord-010092-uftc8inx 6194 18 RBC RBC NNP cord-010092-uftc8inx 6194 19 filter filter NN cord-010092-uftc8inx 6194 20 was be VBD cord-010092-uftc8inx 6194 21 evaluated evaluate VBN cord-010092-uftc8inx 6194 22 . . . cord-010092-uftc8inx 6195 1 All all DT cord-010092-uftc8inx 6195 2 quality quality NN cord-010092-uftc8inx 6195 3 parameters parameter NNS cord-010092-uftc8inx 6195 4 complied comply VBD cord-010092-uftc8inx 6195 5 with with IN cord-010092-uftc8inx 6195 6 Italian italian JJ cord-010092-uftc8inx 6195 7 and and CC cord-010092-uftc8inx 6195 8 European european JJ cord-010092-uftc8inx 6195 9 guidelines guideline NNS cord-010092-uftc8inx 6195 10 and and CC cord-010092-uftc8inx 6195 11 requirements requirement NNS cord-010092-uftc8inx 6195 12 . . . cord-010092-uftc8inx 6196 1 In in IN cord-010092-uftc8inx 6196 2 conclusion conclusion NN cord-010092-uftc8inx 6196 3 , , , cord-010092-uftc8inx 6196 4 the the DT cord-010092-uftc8inx 6196 5 set set NN cord-010092-uftc8inx 6196 6 was be VBD cord-010092-uftc8inx 6196 7 found find VBN cord-010092-uftc8inx 6196 8 to to TO cord-010092-uftc8inx 6196 9 be be VB cord-010092-uftc8inx 6196 10 a a DT cord-010092-uftc8inx 6196 11 reliable reliable JJ cord-010092-uftc8inx 6196 12 and and CC cord-010092-uftc8inx 6196 13 efficient efficient JJ cord-010092-uftc8inx 6196 14 collection collection NN cord-010092-uftc8inx 6196 15 and and CC cord-010092-uftc8inx 6196 16 separation separation NN cord-010092-uftc8inx 6196 17 system system NN cord-010092-uftc8inx 6196 18 that that WDT cord-010092-uftc8inx 6196 19 performs perform VBZ cord-010092-uftc8inx 6196 20 consistently consistently RB cord-010092-uftc8inx 6197 1 Background background NN cord-010092-uftc8inx 6197 2 : : : cord-010092-uftc8inx 6198 1 Novel novel JJ cord-010092-uftc8inx 6198 2 devices device NNS cord-010092-uftc8inx 6198 3 for for IN cord-010092-uftc8inx 6198 4 automated automated JJ cord-010092-uftc8inx 6198 5 whole whole JJ cord-010092-uftc8inx 6198 6 blood blood NN cord-010092-uftc8inx 6198 7 processing processing NN cord-010092-uftc8inx 6198 8 ( ( -LRB- cord-010092-uftc8inx 6198 9 Reveos Reveos NNP cord-010092-uftc8inx 6198 10 TM TM NNP cord-010092-uftc8inx 6198 11 Terumo Terumo NNP cord-010092-uftc8inx 6198 12 BCT BCT NNP cord-010092-uftc8inx 6198 13 ) ) -RRB- cord-010092-uftc8inx 6198 14 have have VBP cord-010092-uftc8inx 6198 15 been be VBN cord-010092-uftc8inx 6198 16 installed instal VBN cord-010092-uftc8inx 6198 17 in in IN cord-010092-uftc8inx 6198 18 Regional Regional NNP cord-010092-uftc8inx 6198 19 Center Center NNP cord-010092-uftc8inx 6198 20 for for IN cord-010092-uftc8inx 6198 21 Blood Blood NNP cord-010092-uftc8inx 6198 22 Donation Donation NNP cord-010092-uftc8inx 6198 23 and and CC cord-010092-uftc8inx 6198 24 Blood Blood NNP cord-010092-uftc8inx 6198 25 Treatment Treatment NNP cord-010092-uftc8inx 6198 26 in in IN cord-010092-uftc8inx 6198 27 Katowice Katowice NNP cord-010092-uftc8inx 6198 28 to to TO cord-010092-uftc8inx 6198 29 modernize modernize VB cord-010092-uftc8inx 6198 30 and and CC cord-010092-uftc8inx 6198 31 automate automate VB cord-010092-uftc8inx 6198 32 production production NN cord-010092-uftc8inx 6198 33 of of IN cord-010092-uftc8inx 6198 34 blood blood NN cord-010092-uftc8inx 6198 35 components component NNS cord-010092-uftc8inx 6198 36 . . . cord-010092-uftc8inx 6199 1 This this DT cord-010092-uftc8inx 6199 2 system system NN cord-010092-uftc8inx 6199 3 allows allow VBZ cord-010092-uftc8inx 6199 4 to to IN cord-010092-uftc8inx 6199 5 separation separation NN cord-010092-uftc8inx 6199 6 of of IN cord-010092-uftc8inx 6199 7 four four CD cord-010092-uftc8inx 6199 8 whole whole JJ cord-010092-uftc8inx 6199 9 blood blood NN cord-010092-uftc8inx 6199 10 units unit NNS cord-010092-uftc8inx 6199 11 into into IN cord-010092-uftc8inx 6200 1 four four CD cord-010092-uftc8inx 6200 2 buffy buffy NNP cord-010092-uftc8inx 6200 3 coat coat NN cord-010092-uftc8inx 6200 4 depleted deplete VBD cord-010092-uftc8inx 6200 5 red red JJ cord-010092-uftc8inx 6200 6 blood blood NN cord-010092-uftc8inx 6200 7 cell cell NN cord-010092-uftc8inx 6200 8 concentrates concentrate VBZ cord-010092-uftc8inx 6200 9 ( ( -LRB- cord-010092-uftc8inx 6200 10 RBC RBC NNP cord-010092-uftc8inx 6200 11 ) ) -RRB- cord-010092-uftc8inx 6200 12 , , , cord-010092-uftc8inx 6200 13 four four CD cord-010092-uftc8inx 6200 14 units unit NNS cord-010092-uftc8inx 6200 15 of of IN cord-010092-uftc8inx 6200 16 plasma plasma NN cord-010092-uftc8inx 6200 17 and and CC cord-010092-uftc8inx 6200 18 four four CD cord-010092-uftc8inx 6200 19 interim interim JJ cord-010092-uftc8inx 6200 20 platelet platelet NN cord-010092-uftc8inx 6200 21 concentrate concentrate NN cord-010092-uftc8inx 6200 22 ( ( -LRB- cord-010092-uftc8inx 6200 23 IPU IPU NNP cord-010092-uftc8inx 6200 24 ) ) -RRB- cord-010092-uftc8inx 6200 25 units unit NNS cord-010092-uftc8inx 6200 26 in in IN cord-010092-uftc8inx 6200 27 one one CD cord-010092-uftc8inx 6200 28 automatic automatic JJ cord-010092-uftc8inx 6200 29 cycle cycle NN cord-010092-uftc8inx 6200 30 . . . cord-010092-uftc8inx 6201 1 An an DT cord-010092-uftc8inx 6201 2 IPU IPU NNP cord-010092-uftc8inx 6201 3 is be VBZ cord-010092-uftc8inx 6201 4 the the DT cord-010092-uftc8inx 6201 5 starting start VBG cord-010092-uftc8inx 6201 6 blood blood NN cord-010092-uftc8inx 6201 7 component component NN cord-010092-uftc8inx 6201 8 for for IN cord-010092-uftc8inx 6201 9 the the DT cord-010092-uftc8inx 6201 10 production production NN cord-010092-uftc8inx 6201 11 of of IN cord-010092-uftc8inx 6201 12 pooled pool VBN cord-010092-uftc8inx 6201 13 , , , cord-010092-uftc8inx 6201 14 leucoreduced leucoreduced JJ cord-010092-uftc8inx 6201 15 platelet platelet NN cord-010092-uftc8inx 6201 16 concentrates concentrate VBZ cord-010092-uftc8inx 6201 17 ( ( -LRB- cord-010092-uftc8inx 6201 18 LPC LPC NNP cord-010092-uftc8inx 6201 19 ) ) -RRB- cord-010092-uftc8inx 6201 20 . . . cord-010092-uftc8inx 6202 1 Residual residual JJ cord-010092-uftc8inx 6202 2 leukocytes leukocyte NNS cord-010092-uftc8inx 6202 3 ( ( -LRB- cord-010092-uftc8inx 6202 4 WBC WBC NNP cord-010092-uftc8inx 6202 5 ) ) -RRB- cord-010092-uftc8inx 6202 6 are be VBP cord-010092-uftc8inx 6202 7 obtained obtain VBN cord-010092-uftc8inx 6202 8 as as IN cord-010092-uftc8inx 6202 9 a a DT cord-010092-uftc8inx 6202 10 byproduct byproduct NN cord-010092-uftc8inx 6202 11 and and CC cord-010092-uftc8inx 6202 12 discarded discard VBN cord-010092-uftc8inx 6202 13 . . . cord-010092-uftc8inx 6203 1 The the DT cord-010092-uftc8inx 6203 2 use use NN cord-010092-uftc8inx 6203 3 of of IN cord-010092-uftc8inx 6203 4 this this DT cord-010092-uftc8inx 6203 5 system system NN cord-010092-uftc8inx 6203 6 shortens shorten VBZ cord-010092-uftc8inx 6203 7 production production NN cord-010092-uftc8inx 6203 8 time time NN cord-010092-uftc8inx 6203 9 because because IN cord-010092-uftc8inx 6203 10 it -PRON- PRP cord-010092-uftc8inx 6203 11 combines combine VBZ cord-010092-uftc8inx 6203 12 otherwise otherwise RB cord-010092-uftc8inx 6203 13 two two CD cord-010092-uftc8inx 6203 14 separate separate JJ cord-010092-uftc8inx 6203 15 steps step NNS cord-010092-uftc8inx 6203 16 : : : cord-010092-uftc8inx 6203 17 centrifugation centrifugation NN cord-010092-uftc8inx 6203 18 and and CC cord-010092-uftc8inx 6203 19 blood blood NN cord-010092-uftc8inx 6203 20 separation separation NN cord-010092-uftc8inx 6203 21 in in IN cord-010092-uftc8inx 6203 22 press press NN cord-010092-uftc8inx 6203 23 . . . cord-010092-uftc8inx 6204 1 Aims aim VBZ cord-010092-uftc8inx 6204 2 : : : cord-010092-uftc8inx 6204 3 To to TO cord-010092-uftc8inx 6204 4 evaluate evaluate VB cord-010092-uftc8inx 6204 5 the the DT cord-010092-uftc8inx 6204 6 quality quality NN cord-010092-uftc8inx 6204 7 of of IN cord-010092-uftc8inx 6204 8 the the DT cord-010092-uftc8inx 6204 9 blood blood NN cord-010092-uftc8inx 6204 10 components component NNS cord-010092-uftc8inx 6204 11 obtained obtain VBN cord-010092-uftc8inx 6204 12 with with IN cord-010092-uftc8inx 6204 13 the the DT cord-010092-uftc8inx 6204 14 newly newly RB cord-010092-uftc8inx 6204 15 developed develop VBN cord-010092-uftc8inx 6204 16 Reveos Reveos NNP cord-010092-uftc8inx 6204 17 NLR NLR NNP cord-010092-uftc8inx 6204 18 kits kit NNS cord-010092-uftc8inx 6204 19 , , , cord-010092-uftc8inx 6204 20 which which WDT cord-010092-uftc8inx 6204 21 are be VBP cord-010092-uftc8inx 6204 22 a a DT cord-010092-uftc8inx 6204 23 whole whole JJ cord-010092-uftc8inx 6204 24 blood blood NN cord-010092-uftc8inx 6204 25 collection collection NN cord-010092-uftc8inx 6204 26 kits kit NNS cord-010092-uftc8inx 6204 27 containing contain VBG cord-010092-uftc8inx 6204 28 no no DT cord-010092-uftc8inx 6204 29 leucocyte leucocyte NNP cord-010092-uftc8inx 6204 30 reduction reduction NN cord-010092-uftc8inx 6204 31 filter filter NN cord-010092-uftc8inx 6204 32 for for IN cord-010092-uftc8inx 6204 33 the the DT cord-010092-uftc8inx 6204 34 RBCs rbc NNS cord-010092-uftc8inx 6204 35 . . . cord-010092-uftc8inx 6205 1 Methods method NNS cord-010092-uftc8inx 6205 2 : : : cord-010092-uftc8inx 6206 1 Blood blood NN cord-010092-uftc8inx 6206 2 [ [ -LRB- cord-010092-uftc8inx 6206 3 WB WB NNP cord-010092-uftc8inx 6206 4 ] ] -RRB- cord-010092-uftc8inx 6206 5 was be VBD cord-010092-uftc8inx 6206 6 collected collect VBN cord-010092-uftc8inx 6206 7 into into IN cord-010092-uftc8inx 6206 8 NLR NLR NNP cord-010092-uftc8inx 6206 9 Reveos Reveos NNP cord-010092-uftc8inx 6206 10 set set VBD cord-010092-uftc8inx 6206 11 ( ( -LRB- cord-010092-uftc8inx 6206 12 Terumo Terumo NNP cord-010092-uftc8inx 6206 13 BCT BCT NNP cord-010092-uftc8inx 6206 14 ) ) -RRB- cord-010092-uftc8inx 6206 15 , , , cord-010092-uftc8inx 6206 16 and and CC cord-010092-uftc8inx 6206 17 processed process VBN cord-010092-uftc8inx 6206 18 between between IN cord-010092-uftc8inx 6206 19 2 2 CD cord-010092-uftc8inx 6206 20 and and CC cord-010092-uftc8inx 6206 21 8 8 CD cord-010092-uftc8inx 6206 22 h h NN cord-010092-uftc8inx 6206 23 from from IN cord-010092-uftc8inx 6206 24 collection collection NN cord-010092-uftc8inx 6206 25 using use VBG cord-010092-uftc8inx 6206 26 the the DT cord-010092-uftc8inx 6206 27 3C 3C NNP cord-010092-uftc8inx 6206 28 protocol protocol NNP cord-010092-uftc8inx 6206 29 . . . cord-010092-uftc8inx 6207 1 Quality quality NN cord-010092-uftc8inx 6207 2 control control NN cord-010092-uftc8inx 6207 3 was be VBD cord-010092-uftc8inx 6207 4 performed perform VBN cord-010092-uftc8inx 6207 5 on on IN cord-010092-uftc8inx 6207 6 RBC RBC NNP cord-010092-uftc8inx 6207 7 , , , cord-010092-uftc8inx 6207 8 plasma plasma NN cord-010092-uftc8inx 6207 9 and and CC cord-010092-uftc8inx 6207 10 IPU IPU NNP cord-010092-uftc8inx 6207 11 . . . cord-010092-uftc8inx 6208 1 RBC RBC NNP cord-010092-uftc8inx 6208 2 were be VBD cord-010092-uftc8inx 6208 3 tested test VBN cord-010092-uftc8inx 6208 4 for for IN cord-010092-uftc8inx 6208 5 hemoglobin hemoglobin NN cord-010092-uftc8inx 6208 6 ( ( -LRB- cord-010092-uftc8inx 6208 7 Hb Hb NNP cord-010092-uftc8inx 6208 8 ) ) -RRB- cord-010092-uftc8inx 6208 9 content content NN cord-010092-uftc8inx 6208 10 , , , cord-010092-uftc8inx 6208 11 hematocrit hematocrit NN cord-010092-uftc8inx 6208 12 ( ( -LRB- cord-010092-uftc8inx 6208 13 Ht Ht NNP cord-010092-uftc8inx 6208 14 ) ) -RRB- cord-010092-uftc8inx 6208 15 , , , cord-010092-uftc8inx 6208 16 residual residual JJ cord-010092-uftc8inx 6208 17 white white JJ cord-010092-uftc8inx 6208 18 blood blood NN cord-010092-uftc8inx 6208 19 cells cell NNS cord-010092-uftc8inx 6208 20 ( ( -LRB- cord-010092-uftc8inx 6208 21 WBC WBC NNP cord-010092-uftc8inx 6208 22 ) ) -RRB- cord-010092-uftc8inx 6208 23 , , , cord-010092-uftc8inx 6208 24 volume volume NN cord-010092-uftc8inx 6208 25 and and CC cord-010092-uftc8inx 6208 26 hemolysis hemolysis NN cord-010092-uftc8inx 6208 27 level level NN cord-010092-uftc8inx 6208 28 on on IN cord-010092-uftc8inx 6208 29 the the DT cord-010092-uftc8inx 6208 30 last last JJ cord-010092-uftc8inx 6208 31 day day NN cord-010092-uftc8inx 6208 32 ( ( -LRB- cord-010092-uftc8inx 6208 33 42 42 CD cord-010092-uftc8inx 6208 34 nd nd NNP cord-010092-uftc8inx 6208 35 day day NN cord-010092-uftc8inx 6208 36 ) ) -RRB- cord-010092-uftc8inx 6208 37 of of IN cord-010092-uftc8inx 6208 38 storage storage NN cord-010092-uftc8inx 6208 39 . . . cord-010092-uftc8inx 6209 1 The the DT cord-010092-uftc8inx 6209 2 content content NN cord-010092-uftc8inx 6209 3 of of IN cord-010092-uftc8inx 6209 4 WBC WBC NNP cord-010092-uftc8inx 6209 5 and and CC cord-010092-uftc8inx 6209 6 platelet platelet NN cord-010092-uftc8inx 6209 7 count count NN cord-010092-uftc8inx 6209 8 ( ( -LRB- cord-010092-uftc8inx 6209 9 PLT PLT NNP cord-010092-uftc8inx 6209 10 ) ) -RRB- cord-010092-uftc8inx 6209 11 , , , cord-010092-uftc8inx 6209 12 protein protein NN cord-010092-uftc8inx 6209 13 , , , cord-010092-uftc8inx 6209 14 factor factor NN cord-010092-uftc8inx 6209 15 VIII VIII NNP cord-010092-uftc8inx 6209 16 on on IN cord-010092-uftc8inx 6209 17 the the DT cord-010092-uftc8inx 6209 18 day day NN cord-010092-uftc8inx 6209 19 of of IN cord-010092-uftc8inx 6209 20 production production NN cord-010092-uftc8inx 6209 21 and and CC cord-010092-uftc8inx 6209 22 after after IN cord-010092-uftc8inx 6209 23 one one CD cord-010092-uftc8inx 6209 24 month month NN cord-010092-uftc8inx 6209 25 of of IN cord-010092-uftc8inx 6209 26 storage storage NN cord-010092-uftc8inx 6209 27 were be VBD cord-010092-uftc8inx 6209 28 determined determine VBN cord-010092-uftc8inx 6209 29 in in IN cord-010092-uftc8inx 6209 30 plasma plasma NN cord-010092-uftc8inx 6209 31 . . . cord-010092-uftc8inx 6210 1 For for IN cord-010092-uftc8inx 6210 2 IPU IPU NNP cord-010092-uftc8inx 6210 3 , , , cord-010092-uftc8inx 6210 4 platelet platelet NN cord-010092-uftc8inx 6210 5 and and CC cord-010092-uftc8inx 6210 6 leucocyte leucocyte NN cord-010092-uftc8inx 6210 7 counts count NNS cord-010092-uftc8inx 6210 8 , , , cord-010092-uftc8inx 6210 9 volume volume NN cord-010092-uftc8inx 6210 10 and and CC cord-010092-uftc8inx 6210 11 average average JJ cord-010092-uftc8inx 6210 12 platelet platelet NN cord-010092-uftc8inx 6210 13 yield yield NN cord-010092-uftc8inx 6210 14 index index NN cord-010092-uftc8inx 6210 15 ( ( -LRB- cord-010092-uftc8inx 6210 16 PYI PYI NNP cord-010092-uftc8inx 6210 17 ) ) -RRB- cord-010092-uftc8inx 6210 18 were be VBD cord-010092-uftc8inx 6210 19 displayed display VBN cord-010092-uftc8inx 6210 20 at at IN cord-010092-uftc8inx 6210 21 the the DT cord-010092-uftc8inx 6210 22 device device NN cord-010092-uftc8inx 6210 23 after after IN cord-010092-uftc8inx 6210 24 processing processing NN cord-010092-uftc8inx 6210 25 was be VBD cord-010092-uftc8inx 6210 26 recorded record VBN cord-010092-uftc8inx 6210 27 . . . cord-010092-uftc8inx 6211 1 Furthermore furthermore RB cord-010092-uftc8inx 6211 2 , , , cord-010092-uftc8inx 6211 3 a a DT cord-010092-uftc8inx 6211 4 comparison comparison NN cord-010092-uftc8inx 6211 5 between between IN cord-010092-uftc8inx 6211 6 fully fully RB cord-010092-uftc8inx 6211 7 automated automate VBN cord-010092-uftc8inx 6211 8 and and CC cord-010092-uftc8inx 6211 9 semi semi RB cord-010092-uftc8inx 6211 10 - - JJ cord-010092-uftc8inx 6211 11 automated automated JJ cord-010092-uftc8inx 6211 12 whole whole JJ cord-010092-uftc8inx 6211 13 blood blood NN cord-010092-uftc8inx 6211 14 processing processing NN cord-010092-uftc8inx 6211 15 was be VBD cord-010092-uftc8inx 6211 16 done do VBN cord-010092-uftc8inx 6211 17 , , , cord-010092-uftc8inx 6211 18 by by IN cord-010092-uftc8inx 6211 19 comparing compare VBG cord-010092-uftc8inx 6211 20 the the DT cord-010092-uftc8inx 6211 21 amount amount NN cord-010092-uftc8inx 6211 22 of of IN cord-010092-uftc8inx 6211 23 time time NN cord-010092-uftc8inx 6211 24 necessary necessary JJ cord-010092-uftc8inx 6211 25 to to TO cord-010092-uftc8inx 6211 26 fractionate fractionate VB cord-010092-uftc8inx 6211 27 4 4 CD cord-010092-uftc8inx 6211 28 whole whole JJ cord-010092-uftc8inx 6211 29 blood blood NN cord-010092-uftc8inx 6211 30 units unit NNS cord-010092-uftc8inx 6211 31 using use VBG cord-010092-uftc8inx 6211 32 the the DT cord-010092-uftc8inx 6211 33 two two CD cord-010092-uftc8inx 6211 34 different different JJ cord-010092-uftc8inx 6211 35 processes process NNS cord-010092-uftc8inx 6211 36 . . . cord-010092-uftc8inx 6212 1 Background background NN cord-010092-uftc8inx 6212 2 : : : cord-010092-uftc8inx 6213 1 Direct direct JJ cord-010092-uftc8inx 6213 2 , , , cord-010092-uftc8inx 6213 3 single single JJ cord-010092-uftc8inx 6213 4 step step NN cord-010092-uftc8inx 6213 5 automatic automatic JJ cord-010092-uftc8inx 6213 6 blood blood NN cord-010092-uftc8inx 6213 7 separation separation NN cord-010092-uftc8inx 6213 8 devices device NNS cord-010092-uftc8inx 6213 9 ( ( -LRB- cord-010092-uftc8inx 6213 10 Reveos Reveos NNP cord-010092-uftc8inx 6213 11 TM TM NNP cord-010092-uftc8inx 6213 12 Terumo Terumo NNP cord-010092-uftc8inx 6213 13 BCT BCT NNP cord-010092-uftc8inx 6213 14 ) ) -RRB- cord-010092-uftc8inx 6213 15 was be VBD cord-010092-uftc8inx 6213 16 installed instal VBN cord-010092-uftc8inx 6213 17 in in IN cord-010092-uftc8inx 6213 18 Regional Regional NNP cord-010092-uftc8inx 6213 19 Center Center NNP cord-010092-uftc8inx 6213 20 in in IN cord-010092-uftc8inx 6213 21 Katowice Katowice NNP cord-010092-uftc8inx 6213 22 in in IN cord-010092-uftc8inx 6213 23 2018 2018 CD cord-010092-uftc8inx 6213 24 . . . cord-010092-uftc8inx 6214 1 The the DT cord-010092-uftc8inx 6214 2 system system NN cord-010092-uftc8inx 6214 3 allows allow VBZ cord-010092-uftc8inx 6214 4 for for IN cord-010092-uftc8inx 6214 5 full full JJ cord-010092-uftc8inx 6214 6 automation automation NN cord-010092-uftc8inx 6214 7 of of IN cord-010092-uftc8inx 6214 8 whole whole JJ cord-010092-uftc8inx 6214 9 blood blood NN cord-010092-uftc8inx 6214 10 fractionation fractionation NN cord-010092-uftc8inx 6214 11 . . . cord-010092-uftc8inx 6215 1 One one CD cord-010092-uftc8inx 6215 2 of of IN cord-010092-uftc8inx 6215 3 produced produce VBN cord-010092-uftc8inx 6215 4 blood blood NN cord-010092-uftc8inx 6215 5 components component NNS cord-010092-uftc8inx 6215 6 is be VBZ cord-010092-uftc8inx 6215 7 an an DT cord-010092-uftc8inx 6215 8 interim interim JJ cord-010092-uftc8inx 6215 9 platelet platelet NN cord-010092-uftc8inx 6215 10 unit unit NN cord-010092-uftc8inx 6215 11 ( ( -LRB- cord-010092-uftc8inx 6215 12 IPU IPU NNP cord-010092-uftc8inx 6215 13 ) ) -RRB- cord-010092-uftc8inx 6215 14 , , , cord-010092-uftc8inx 6215 15 containing contain VBG cord-010092-uftc8inx 6215 16 most most JJS cord-010092-uftc8inx 6215 17 of of IN cord-010092-uftc8inx 6215 18 the the DT cord-010092-uftc8inx 6215 19 platelets platelet NNS cord-010092-uftc8inx 6215 20 and and CC cord-010092-uftc8inx 6215 21 limited limit VBN cord-010092-uftc8inx 6215 22 of of IN cord-010092-uftc8inx 6215 23 white white JJ cord-010092-uftc8inx 6215 24 blood blood NN cord-010092-uftc8inx 6215 25 cells cell NNS cord-010092-uftc8inx 6215 26 ( ( -LRB- cord-010092-uftc8inx 6215 27 WBCs wbc NNS cord-010092-uftc8inx 6215 28 ) ) -RRB- cord-010092-uftc8inx 6215 29 . . . cord-010092-uftc8inx 6216 1 It -PRON- PRP cord-010092-uftc8inx 6216 2 is be VBZ cord-010092-uftc8inx 6216 3 then then RB cord-010092-uftc8inx 6216 4 pooled pool VBN cord-010092-uftc8inx 6216 5 through through IN cord-010092-uftc8inx 6216 6 a a DT cord-010092-uftc8inx 6216 7 filter filter NN cord-010092-uftc8inx 6216 8 to to TO cord-010092-uftc8inx 6216 9 form form VB cord-010092-uftc8inx 6216 10 a a DT cord-010092-uftc8inx 6216 11 therapeutic therapeutic JJ cord-010092-uftc8inx 6216 12 unit unit NN cord-010092-uftc8inx 6216 13 of of IN cord-010092-uftc8inx 6216 14 leucoreduced leucoreduced JJ cord-010092-uftc8inx 6216 15 platelet platelet NN cord-010092-uftc8inx 6216 16 concentrate concentrate NN cord-010092-uftc8inx 6216 17 ( ( -LRB- cord-010092-uftc8inx 6216 18 LPC LPC NNP cord-010092-uftc8inx 6216 19 ) ) -RRB- cord-010092-uftc8inx 6216 20 . . . cord-010092-uftc8inx 6217 1 A a DT cord-010092-uftc8inx 6217 2 rough rough JJ cord-010092-uftc8inx 6217 3 estimate estimate NN cord-010092-uftc8inx 6217 4 of of IN cord-010092-uftc8inx 6217 5 the the DT cord-010092-uftc8inx 6217 6 platelet platelet NN cord-010092-uftc8inx 6217 7 yield yield NN cord-010092-uftc8inx 6217 8 in in IN cord-010092-uftc8inx 6217 9 the the DT cord-010092-uftc8inx 6217 10 IPU IPU NNP cord-010092-uftc8inx 6217 11 , , , cord-010092-uftc8inx 6217 12 the the DT cord-010092-uftc8inx 6217 13 so so RB cord-010092-uftc8inx 6217 14 - - HYPH cord-010092-uftc8inx 6217 15 called call VBN cord-010092-uftc8inx 6217 16 platelet platelet NN cord-010092-uftc8inx 6217 17 yield yield NN cord-010092-uftc8inx 6217 18 index index NN cord-010092-uftc8inx 6217 19 ( ( -LRB- cord-010092-uftc8inx 6217 20 PYI PYI NNP cord-010092-uftc8inx 6217 21 ) ) -RRB- cord-010092-uftc8inx 6217 22 is be VBZ cord-010092-uftc8inx 6217 23 calculated calculate VBN cord-010092-uftc8inx 6217 24 and and CC cord-010092-uftc8inx 6217 25 displayed display VBN cord-010092-uftc8inx 6217 26 by by IN cord-010092-uftc8inx 6217 27 the the DT cord-010092-uftc8inx 6217 28 device device NN cord-010092-uftc8inx 6217 29 after after IN cord-010092-uftc8inx 6217 30 the the DT cord-010092-uftc8inx 6217 31 end end NN cord-010092-uftc8inx 6217 32 of of IN cord-010092-uftc8inx 6217 33 the the DT cord-010092-uftc8inx 6217 34 separation separation NN cord-010092-uftc8inx 6217 35 phase phase NN cord-010092-uftc8inx 6217 36 . . . cord-010092-uftc8inx 6218 1 It -PRON- PRP cord-010092-uftc8inx 6218 2 is be VBZ cord-010092-uftc8inx 6218 3 a a DT cord-010092-uftc8inx 6218 4 useful useful JJ cord-010092-uftc8inx 6218 5 tool tool NN cord-010092-uftc8inx 6218 6 to to TO cord-010092-uftc8inx 6218 7 optimize optimize VB cord-010092-uftc8inx 6218 8 selection selection NN cord-010092-uftc8inx 6218 9 of of IN cord-010092-uftc8inx 6218 10 IPU IPU NNP cord-010092-uftc8inx 6218 11 for for IN cord-010092-uftc8inx 6218 12 pools pool NNS cord-010092-uftc8inx 6218 13 to to TO cord-010092-uftc8inx 6218 14 produce produce VB cord-010092-uftc8inx 6218 15 LPC LPC NNP cord-010092-uftc8inx 6218 16 . . . cord-010092-uftc8inx 6219 1 Aims aim VBZ cord-010092-uftc8inx 6219 2 : : : cord-010092-uftc8inx 6219 3 To to TO cord-010092-uftc8inx 6219 4 determine determine VB cord-010092-uftc8inx 6219 5 the the DT cord-010092-uftc8inx 6219 6 quality quality NN cord-010092-uftc8inx 6219 7 of of IN cord-010092-uftc8inx 6219 8 polled poll VBN cord-010092-uftc8inx 6219 9 LPC LPC NNP cord-010092-uftc8inx 6219 10 obtained obtain VBD cord-010092-uftc8inx 6219 11 on on IN cord-010092-uftc8inx 6219 12 the the DT cord-010092-uftc8inx 6219 13 basis basis NN cord-010092-uftc8inx 6219 14 of of IN cord-010092-uftc8inx 6219 15 IPU IPU NNP cord-010092-uftc8inx 6219 16 from from IN cord-010092-uftc8inx 6219 17 whole whole JJ cord-010092-uftc8inx 6219 18 blood blood NN cord-010092-uftc8inx 6219 19 processed process VBN cord-010092-uftc8inx 6219 20 up up RP cord-010092-uftc8inx 6219 21 to to TO cord-010092-uftc8inx 6219 22 8 8 CD cord-010092-uftc8inx 6219 23 h h NN cord-010092-uftc8inx 6219 24 after after IN cord-010092-uftc8inx 6219 25 collection collection NN cord-010092-uftc8inx 6219 26 and and CC cord-010092-uftc8inx 6219 27 the the DT cord-010092-uftc8inx 6219 28 usefulness usefulness NN cord-010092-uftc8inx 6219 29 of of IN cord-010092-uftc8inx 6219 30 this this DT cord-010092-uftc8inx 6219 31 method method NN cord-010092-uftc8inx 6219 32 in in IN cord-010092-uftc8inx 6219 33 daily daily JJ cord-010092-uftc8inx 6219 34 practice practice NN cord-010092-uftc8inx 6219 35 . . . cord-010092-uftc8inx 6220 1 Methods method NNS cord-010092-uftc8inx 6220 2 : : : cord-010092-uftc8inx 6220 3 IPUs ipu NNS cord-010092-uftc8inx 6220 4 used use VBN cord-010092-uftc8inx 6220 5 for for IN cord-010092-uftc8inx 6220 6 production production NN cord-010092-uftc8inx 6220 7 of of IN cord-010092-uftc8inx 6220 8 LPC LPC NNP cord-010092-uftc8inx 6220 9 were be VBD cord-010092-uftc8inx 6220 10 obtained obtain VBN cord-010092-uftc8inx 6220 11 using use VBG cord-010092-uftc8inx 6220 12 fully fully RB cord-010092-uftc8inx 6220 13 automated automate VBN cord-010092-uftc8inx 6220 14 whole whole JJ cord-010092-uftc8inx 6220 15 blood blood NN cord-010092-uftc8inx 6220 16 processing process VBG cord-010092-uftc8inx 6220 17 single single JJ cord-010092-uftc8inx 6220 18 step step NN cord-010092-uftc8inx 6220 19 system system NN cord-010092-uftc8inx 6220 20 -Reveos -Reveos . cord-010092-uftc8inx 6221 1 TM TM NNP cord-010092-uftc8inx 6221 2 ( ( -LRB- cord-010092-uftc8inx 6221 3 Terumo Terumo NNP cord-010092-uftc8inx 6221 4 BCT BCT NNP cord-010092-uftc8inx 6221 5 ) ) -RRB- cord-010092-uftc8inx 6221 6 . . . cord-010092-uftc8inx 6222 1 From from IN cord-010092-uftc8inx 6222 2 the the DT cord-010092-uftc8inx 6222 3 beginning beginning NN cord-010092-uftc8inx 6222 4 of of IN cord-010092-uftc8inx 6222 5 the the DT cord-010092-uftc8inx 6222 6 application application NN cord-010092-uftc8inx 6222 7 of of IN cord-010092-uftc8inx 6222 8 the the DT cord-010092-uftc8inx 6222 9 method method NN cord-010092-uftc8inx 6222 10 , , , cord-010092-uftc8inx 6222 11 1005 1005 CD cord-010092-uftc8inx 6222 12 therapeutic therapeutic JJ cord-010092-uftc8inx 6222 13 units unit NNS cord-010092-uftc8inx 6222 14 of of IN cord-010092-uftc8inx 6222 15 LPCs lpc NNS cord-010092-uftc8inx 6222 16 were be VBD cord-010092-uftc8inx 6222 17 produced produce VBN cord-010092-uftc8inx 6222 18 after after IN cord-010092-uftc8inx 6222 19 overnight overnight JJ cord-010092-uftc8inx 6222 20 hold hold NN cord-010092-uftc8inx 6222 21 : : : cord-010092-uftc8inx 6222 22 38 38 CD cord-010092-uftc8inx 6222 23 pools pool NNS cord-010092-uftc8inx 6222 24 of of IN cord-010092-uftc8inx 6222 25 4 4 CD cord-010092-uftc8inx 6222 26 IPUs ipu NNS cord-010092-uftc8inx 6222 27 and and CC cord-010092-uftc8inx 6222 28 966 966 CD cord-010092-uftc8inx 6222 29 of of IN cord-010092-uftc8inx 6222 30 5 5 CD cord-010092-uftc8inx 6222 31 IPUs ipu NNS cord-010092-uftc8inx 6222 32 were be VBD cord-010092-uftc8inx 6222 33 made make VBN cord-010092-uftc8inx 6222 34 using use VBG cord-010092-uftc8inx 6222 35 Platelet platelet NN cord-010092-uftc8inx 6222 36 Pooling Pooling NNP cord-010092-uftc8inx 6222 37 Set Set NNP cord-010092-uftc8inx 6222 38 ( ( -LRB- cord-010092-uftc8inx 6222 39 Terumo Terumo NNP cord-010092-uftc8inx 6222 40 BCT BCT NNP cord-010092-uftc8inx 6222 41 ) ) -RRB- cord-010092-uftc8inx 6222 42 , , , cord-010092-uftc8inx 6222 43 using use VBG cord-010092-uftc8inx 6222 44 250 250 CD cord-010092-uftc8inx 6222 45 ml ml NN cord-010092-uftc8inx 6222 46 SSP+ ssp+ NN cord-010092-uftc8inx 6222 47 solution solution NN cord-010092-uftc8inx 6222 48 ( ( -LRB- cord-010092-uftc8inx 6222 49 MacoPharma MacoPharma NNP cord-010092-uftc8inx 6222 50 ) ) -RRB- cord-010092-uftc8inx 6222 51 . . . cord-010092-uftc8inx 6223 1 Results result NNS cord-010092-uftc8inx 6223 2 : : : cord-010092-uftc8inx 6223 3 42 42 CD cord-010092-uftc8inx 6223 4 therapeutic therapeutic JJ cord-010092-uftc8inx 6223 5 units unit NNS cord-010092-uftc8inx 6223 6 of of IN cord-010092-uftc8inx 6223 7 LPC LPC NNP cord-010092-uftc8inx 6223 8 were be VBD cord-010092-uftc8inx 6223 9 analyzed analyze VBN cord-010092-uftc8inx 6223 10 . . . cord-010092-uftc8inx 6224 1 The the DT cord-010092-uftc8inx 6224 2 mean mean JJ cord-010092-uftc8inx 6224 3 volume volume NN cord-010092-uftc8inx 6224 4 of of IN cord-010092-uftc8inx 6224 5 LPC LPC NNP cord-010092-uftc8inx 6224 6 was be VBD cord-010092-uftc8inx 6224 7 387 387 CD cord-010092-uftc8inx 6224 8 AE AE NNP cord-010092-uftc8inx 6224 9 13 13 CD cord-010092-uftc8inx 6224 10 ml ml NNS cord-010092-uftc8inx 6224 11 , , , cord-010092-uftc8inx 6224 12 platelet platelet NN cord-010092-uftc8inx 6224 13 content content NN cord-010092-uftc8inx 6224 14 was be VBD cord-010092-uftc8inx 6224 15 3.67 3.67 CD cord-010092-uftc8inx 6224 16 AE AE NNP cord-010092-uftc8inx 6224 17 0.46 0.46 CD cord-010092-uftc8inx 6224 18 x10 x10 CD cord-010092-uftc8inx 6224 19 11 11 CD cord-010092-uftc8inx 6224 20 , , , cord-010092-uftc8inx 6224 21 and and CC cord-010092-uftc8inx 6224 22 white white JJ cord-010092-uftc8inx 6224 23 blood blood NN cord-010092-uftc8inx 6224 24 cells cell NNS cord-010092-uftc8inx 6224 25 ( ( -LRB- cord-010092-uftc8inx 6224 26 WBC WBC NNP cord-010092-uftc8inx 6224 27 ) ) -RRB- cord-010092-uftc8inx 6224 28 count count NN cord-010092-uftc8inx 6224 29 was be VBD cord-010092-uftc8inx 6224 30 0.15 0.15 CD cord-010092-uftc8inx 6224 31 AE AE NNP cord-010092-uftc8inx 6224 32 0.13 0.13 CD cord-010092-uftc8inx 6224 33 x10 x10 CD cord-010092-uftc8inx 6224 34 6 6 CD cord-010092-uftc8inx 6224 35 , , , cord-010092-uftc8inx 6224 36 100 100 CD cord-010092-uftc8inx 6224 37 % % NN cord-010092-uftc8inx 6225 1 all all DT cord-010092-uftc8inx 6225 2 LPCs lpc NNS cord-010092-uftc8inx 6225 3 had have VBD cord-010092-uftc8inx 6225 4 WBC WBC NNP cord-010092-uftc8inx 6225 5 below below IN cord-010092-uftc8inx 6225 6 1 1 CD cord-010092-uftc8inx 6225 7 9 9 CD cord-010092-uftc8inx 6225 8 10 10 CD cord-010092-uftc8inx 6225 9 6 6 CD cord-010092-uftc8inx 6225 10 . . . cord-010092-uftc8inx 6226 1 pH pH NNP cord-010092-uftc8inx 6226 2 measurements measurement NNS cord-010092-uftc8inx 6226 3 were be VBD cord-010092-uftc8inx 6226 4 made make VBN cord-010092-uftc8inx 6226 5 on on IN cord-010092-uftc8inx 6226 6 the the DT cord-010092-uftc8inx 6226 7 fifth fifth JJ cord-010092-uftc8inx 6226 8 day day NN cord-010092-uftc8inx 6226 9 of of IN cord-010092-uftc8inx 6226 10 storage storage NN cord-010092-uftc8inx 6226 11 , , , cord-010092-uftc8inx 6226 12 the the DT cord-010092-uftc8inx 6226 13 pH pH NNP cord-010092-uftc8inx 6226 14 was be VBD cord-010092-uftc8inx 6226 15 determined determine VBN cord-010092-uftc8inx 6226 16 in in IN cord-010092-uftc8inx 6226 17 15 15 CD cord-010092-uftc8inx 6226 18 units unit NNS cord-010092-uftc8inx 6226 19 of of IN cord-010092-uftc8inx 6226 20 LPC LPC NNP cord-010092-uftc8inx 6226 21 and and CC cord-010092-uftc8inx 6226 22 was be VBD cord-010092-uftc8inx 6226 23 7.2 7.2 CD cord-010092-uftc8inx 6226 24 AE AE NNP cord-010092-uftc8inx 6226 25 0.04 0.04 CD cord-010092-uftc8inx 6226 26 . . . cord-010092-uftc8inx 6227 1 Summary Summary NNP cord-010092-uftc8inx 6227 2 / / SYM cord-010092-uftc8inx 6227 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 6227 4 : : : cord-010092-uftc8inx 6228 1 The the DT cord-010092-uftc8inx 6228 2 use use NN cord-010092-uftc8inx 6228 3 of of IN cord-010092-uftc8inx 6228 4 interim interim JJ cord-010092-uftc8inx 6228 5 platelet platelet NN cord-010092-uftc8inx 6228 6 units unit NNS cord-010092-uftc8inx 6228 7 in in IN cord-010092-uftc8inx 6228 8 daily daily JJ cord-010092-uftc8inx 6228 9 practice practice NN cord-010092-uftc8inx 6228 10 increases increase VBZ cord-010092-uftc8inx 6228 11 the the DT cord-010092-uftc8inx 6228 12 possibility possibility NN cord-010092-uftc8inx 6228 13 of of IN cord-010092-uftc8inx 6228 14 producing produce VBG cord-010092-uftc8inx 6228 15 high high JJ cord-010092-uftc8inx 6228 16 quality quality NN cord-010092-uftc8inx 6228 17 blood blood NN cord-010092-uftc8inx 6228 18 components component NNS cord-010092-uftc8inx 6228 19 for for IN cord-010092-uftc8inx 6228 20 patients patient NNS cord-010092-uftc8inx 6228 21 and and CC cord-010092-uftc8inx 6228 22 is be VBZ cord-010092-uftc8inx 6228 23 a a DT cord-010092-uftc8inx 6228 24 great great JJ cord-010092-uftc8inx 6228 25 alternative alternative NN cord-010092-uftc8inx 6228 26 to to IN cord-010092-uftc8inx 6228 27 the the DT cord-010092-uftc8inx 6228 28 laborintensive laborintensive JJ cord-010092-uftc8inx 6228 29 manual manual JJ cord-010092-uftc8inx 6228 30 methods method NNS cord-010092-uftc8inx 6228 31 of of IN cord-010092-uftc8inx 6228 32 LPC LPC NNP cord-010092-uftc8inx 6228 33 's 's POS cord-010092-uftc8inx 6228 34 production production NN cord-010092-uftc8inx 6228 35 . . . cord-010092-uftc8inx 6229 1 Background background NN cord-010092-uftc8inx 6229 2 : : : cord-010092-uftc8inx 6230 1 The the DT cord-010092-uftc8inx 6230 2 development development NN cord-010092-uftc8inx 6230 3 of of IN cord-010092-uftc8inx 6230 4 cold cold JJ cord-010092-uftc8inx 6230 5 - - HYPH cord-010092-uftc8inx 6230 6 stored store VBN cord-010092-uftc8inx 6230 7 platelets platelet NNS cord-010092-uftc8inx 6230 8 has have VBZ cord-010092-uftc8inx 6230 9 been be VBN cord-010092-uftc8inx 6230 10 hampered hamper VBN cord-010092-uftc8inx 6230 11 by by IN cord-010092-uftc8inx 6230 12 the the DT cord-010092-uftc8inx 6230 13 rapid rapid JJ cord-010092-uftc8inx 6230 14 removal removal NN cord-010092-uftc8inx 6230 15 of of IN cord-010092-uftc8inx 6230 16 blood blood NN cord-010092-uftc8inx 6230 17 after after IN cord-010092-uftc8inx 6230 18 transfusion transfusion NN cord-010092-uftc8inx 6230 19 by by IN cord-010092-uftc8inx 6230 20 apoptosis apoptosis NN cord-010092-uftc8inx 6230 21 and and CC cord-010092-uftc8inx 6230 22 desialylation desialylation NN cord-010092-uftc8inx 6230 23 due due IN cord-010092-uftc8inx 6230 24 to to IN cord-010092-uftc8inx 6230 25 platelet platelet NN cord-010092-uftc8inx 6230 26 storage storage NN cord-010092-uftc8inx 6230 27 lesions lesion NNS cord-010092-uftc8inx 6230 28 caused cause VBN cord-010092-uftc8inx 6230 29 by by IN cord-010092-uftc8inx 6230 30 refrigeration refrigeration NN cord-010092-uftc8inx 6230 31 . . . cord-010092-uftc8inx 6231 1 Previous previous JJ cord-010092-uftc8inx 6231 2 studies study NNS cord-010092-uftc8inx 6231 3 have have VBP cord-010092-uftc8inx 6231 4 shown show VBN cord-010092-uftc8inx 6231 5 that that IN cord-010092-uftc8inx 6231 6 antioxidants antioxidant NNS cord-010092-uftc8inx 6231 7 inhibited inhibit VBD cord-010092-uftc8inx 6231 8 the the DT cord-010092-uftc8inx 6231 9 activation activation NN cord-010092-uftc8inx 6231 10 and and CC cord-010092-uftc8inx 6231 11 desialylation desialylation NN cord-010092-uftc8inx 6231 12 of of IN cord-010092-uftc8inx 6231 13 cold cold NN cord-010092-uftc8inx 6231 14 - - HYPH cord-010092-uftc8inx 6231 15 stored store VBN cord-010092-uftc8inx 6231 16 platelets platelet NNS cord-010092-uftc8inx 6231 17 for for IN cord-010092-uftc8inx 6231 18 5 5 CD cord-010092-uftc8inx 6231 19 days day NNS cord-010092-uftc8inx 6231 20 and and CC cord-010092-uftc8inx 6231 21 also also RB cord-010092-uftc8inx 6231 22 inhibited inhibit VBN cord-010092-uftc8inx 6231 23 rapid rapid JJ cord-010092-uftc8inx 6231 24 elimination elimination NN cord-010092-uftc8inx 6231 25 after after IN cord-010092-uftc8inx 6231 26 transfusion transfusion NN cord-010092-uftc8inx 6231 27 in in IN cord-010092-uftc8inx 6231 28 animal animal NN cord-010092-uftc8inx 6231 29 models model NNS cord-010092-uftc8inx 6231 30 . . . cord-010092-uftc8inx 6232 1 Aims aim VBZ cord-010092-uftc8inx 6232 2 : : : cord-010092-uftc8inx 6232 3 It -PRON- PRP cord-010092-uftc8inx 6232 4 was be VBD cord-010092-uftc8inx 6232 5 tried try VBN cord-010092-uftc8inx 6232 6 whether whether IN cord-010092-uftc8inx 6232 7 in in IN cord-010092-uftc8inx 6232 8 long long JJ cord-010092-uftc8inx 6232 9 - - HYPH cord-010092-uftc8inx 6232 10 term term NN cord-010092-uftc8inx 6232 11 ( ( -LRB- cord-010092-uftc8inx 6232 12 10 10 CD cord-010092-uftc8inx 6232 13 days day NNS cord-010092-uftc8inx 6232 14 or or CC cord-010092-uftc8inx 6232 15 longer long JJR cord-010092-uftc8inx 6232 16 ) ) -RRB- cord-010092-uftc8inx 6232 17 storage storage NN cord-010092-uftc8inx 6232 18 conditions condition NNS cord-010092-uftc8inx 6232 19 , , , cord-010092-uftc8inx 6232 20 antioxidants antioxidant NNS cord-010092-uftc8inx 6232 21 showed show VBD cord-010092-uftc8inx 6232 22 similar similar JJ cord-010092-uftc8inx 6232 23 effects effect NNS cord-010092-uftc8inx 6232 24 inhibiting inhibit VBG cord-010092-uftc8inx 6232 25 the the DT cord-010092-uftc8inx 6232 26 activation activation NN cord-010092-uftc8inx 6232 27 and and CC cord-010092-uftc8inx 6232 28 desialylation desialylation NN cord-010092-uftc8inx 6232 29 of of IN cord-010092-uftc8inx 6232 30 cold cold NN cord-010092-uftc8inx 6232 31 - - HYPH cord-010092-uftc8inx 6232 32 stored store VBN cord-010092-uftc8inx 6232 33 platelets platelet NNS cord-010092-uftc8inx 6232 34 . . . cord-010092-uftc8inx 6233 1 Methods method NNS cord-010092-uftc8inx 6233 2 : : : cord-010092-uftc8inx 6233 3 Platelet platelet NN cord-010092-uftc8inx 6233 4 - - HYPH cord-010092-uftc8inx 6233 5 rich rich JJ cord-010092-uftc8inx 6233 6 plasma plasma NN cord-010092-uftc8inx 6233 7 ( ( -LRB- cord-010092-uftc8inx 6233 8 about about RB cord-010092-uftc8inx 6233 9 250 250 CD cord-010092-uftc8inx 6233 10 mL ml NN cord-010092-uftc8inx 6233 11 ) ) -RRB- cord-010092-uftc8inx 6233 12 were be VBD cord-010092-uftc8inx 6233 13 obtained obtain VBN cord-010092-uftc8inx 6233 14 from from IN cord-010092-uftc8inx 6233 15 a a DT cord-010092-uftc8inx 6233 16 healthy healthy JJ cord-010092-uftc8inx 6233 17 blood blood NN cord-010092-uftc8inx 6233 18 donors donor NNS cord-010092-uftc8inx 6233 19 of of IN cord-010092-uftc8inx 6233 20 type type NN cord-010092-uftc8inx 6233 21 O o UH cord-010092-uftc8inx 6233 22 blood blood NN cord-010092-uftc8inx 6233 23 group group NN cord-010092-uftc8inx 6233 24 and and CC cord-010092-uftc8inx 6233 25 divided divide VBD cord-010092-uftc8inx 6233 26 into into IN cord-010092-uftc8inx 6233 27 a a DT cord-010092-uftc8inx 6233 28 30 30 CD cord-010092-uftc8inx 6233 29 mL ml NN cord-010092-uftc8inx 6233 30 platelet platelet NN cord-010092-uftc8inx 6233 31 storage storage NN cord-010092-uftc8inx 6233 32 bag bag NN cord-010092-uftc8inx 6233 33 manufactured manufacture VBN cord-010092-uftc8inx 6233 34 by by IN cord-010092-uftc8inx 6233 35 the the DT cord-010092-uftc8inx 6233 36 manufacturer manufacturer NN cord-010092-uftc8inx 6233 37 , , , cord-010092-uftc8inx 6233 38 and and CC cord-010092-uftc8inx 6233 39 the the DT cord-010092-uftc8inx 6233 40 conditions condition NNS cord-010092-uftc8inx 6233 41 including include VBG cord-010092-uftc8inx 6233 42 room room NN cord-010092-uftc8inx 6233 43 temperature temperature NN cord-010092-uftc8inx 6233 44 and and CC cord-010092-uftc8inx 6233 45 refrigerated refrigerated JJ cord-010092-uftc8inx 6233 46 condition condition NN cord-010092-uftc8inx 6233 47 and and CC cord-010092-uftc8inx 6233 48 various various JJ cord-010092-uftc8inx 6233 49 kinds kind NNS cord-010092-uftc8inx 6233 50 of of IN cord-010092-uftc8inx 6233 51 antioxidants antioxidant NNS cord-010092-uftc8inx 6233 52 were be VBD cord-010092-uftc8inx 6233 53 prepared prepare VBN cord-010092-uftc8inx 6233 54 , , , cord-010092-uftc8inx 6233 55 ( ( -LRB- cord-010092-uftc8inx 6233 56 PH PH NNP cord-010092-uftc8inx 6233 57 , , , cord-010092-uftc8inx 6233 58 glucose glucose NN cord-010092-uftc8inx 6233 59 , , , cord-010092-uftc8inx 6233 60 lactic lactic JJ cord-010092-uftc8inx 6233 61 acid acid NN cord-010092-uftc8inx 6233 62 ) ) -RRB- cord-010092-uftc8inx 6233 63 and and CC cord-010092-uftc8inx 6233 64 activation activation NN cord-010092-uftc8inx 6233 65 index index NN cord-010092-uftc8inx 6233 66 ( ( -LRB- cord-010092-uftc8inx 6233 67 CD62P CD62P NNP cord-010092-uftc8inx 6233 68 , , , cord-010092-uftc8inx 6233 69 GPIba GPIba NNP cord-010092-uftc8inx 6233 70 ( ( -LRB- cord-010092-uftc8inx 6233 71 CD42b CD42b NNP cord-010092-uftc8inx 6233 72 ) ) -RRB- cord-010092-uftc8inx 6233 73 , , , cord-010092-uftc8inx 6233 74 Annexin Annexin NNP cord-010092-uftc8inx 6233 75 V V NNP cord-010092-uftc8inx 6233 76 ) ) -RRB- cord-010092-uftc8inx 6233 77 , , , cord-010092-uftc8inx 6233 78 degree degree NN cord-010092-uftc8inx 6233 79 of of IN cord-010092-uftc8inx 6233 80 reactive reactive JJ cord-010092-uftc8inx 6233 81 oxygen oxygen NN cord-010092-uftc8inx 6233 82 species specie NNS cord-010092-uftc8inx 6233 83 and and CC cord-010092-uftc8inx 6233 84 sialidase sialidase NN cord-010092-uftc8inx 6233 85 activity activity NN cord-010092-uftc8inx 6233 86 on on IN cord-010092-uftc8inx 6233 87 the the DT cord-010092-uftc8inx 6233 88 7th 7th JJ cord-010092-uftc8inx 6233 89 , , , cord-010092-uftc8inx 6233 90 10th 10th JJ cord-010092-uftc8inx 6233 91 and and CC cord-010092-uftc8inx 6233 92 12th 12th JJ cord-010092-uftc8inx 6233 93 day day NN cord-010092-uftc8inx 6233 94 , , , cord-010092-uftc8inx 6233 95 and and CC cord-010092-uftc8inx 6233 96 phagocytosis phagocytosis NN cord-010092-uftc8inx 6233 97 using use VBG cord-010092-uftc8inx 6233 98 the the DT cord-010092-uftc8inx 6233 99 HEPG2 HEPG2 NNP cord-010092-uftc8inx 6233 100 cell cell NN cord-010092-uftc8inx 6233 101 line line NN cord-010092-uftc8inx 6233 102 And and CC cord-010092-uftc8inx 6233 103 platelet platelet NN cord-010092-uftc8inx 6233 104 recovery recovery NN cord-010092-uftc8inx 6233 105 after after IN cord-010092-uftc8inx 6233 106 in in IN cord-010092-uftc8inx 6233 107 vivo vivo NN cord-010092-uftc8inx 6233 108 transfusion transfusion NN cord-010092-uftc8inx 6233 109 using use VBG cord-010092-uftc8inx 6233 110 SCID SCID NNP cord-010092-uftc8inx 6233 111 mice mouse NNS cord-010092-uftc8inx 6233 112 were be VBD cord-010092-uftc8inx 6233 113 compared compare VBN cord-010092-uftc8inx 6233 114 and and CC cord-010092-uftc8inx 6233 115 compared compare VBN cord-010092-uftc8inx 6233 116 . . . cord-010092-uftc8inx 6234 1 Results result NNS cord-010092-uftc8inx 6234 2 : : : cord-010092-uftc8inx 6235 1 Cold cold JJ cord-010092-uftc8inx 6235 2 - - HYPH cord-010092-uftc8inx 6235 3 stored store VBN cord-010092-uftc8inx 6235 4 platelets platelet NNS cord-010092-uftc8inx 6235 5 showed show VBD cord-010092-uftc8inx 6235 6 autoaggregation autoaggregation NN cord-010092-uftc8inx 6235 7 on on IN cord-010092-uftc8inx 6235 8 the the DT cord-010092-uftc8inx 6235 9 2nd 2nd JJ cord-010092-uftc8inx 6235 10 day day NN cord-010092-uftc8inx 6235 11 of of IN cord-010092-uftc8inx 6235 12 storage storage NN cord-010092-uftc8inx 6235 13 , , , cord-010092-uftc8inx 6235 14 and and CC cord-010092-uftc8inx 6235 15 apparent apparent JJ cord-010092-uftc8inx 6235 16 aggregation aggregation NN cord-010092-uftc8inx 6235 17 on on IN cord-010092-uftc8inx 6235 18 the the DT cord-010092-uftc8inx 6235 19 fifth fifth JJ cord-010092-uftc8inx 6235 20 day day NN cord-010092-uftc8inx 6235 21 of of IN cord-010092-uftc8inx 6235 22 visual visual JJ cord-010092-uftc8inx 6235 23 observation observation NN cord-010092-uftc8inx 6235 24 but but CC cord-010092-uftc8inx 6235 25 not not RB cord-010092-uftc8inx 6235 26 in in IN cord-010092-uftc8inx 6235 27 the the DT cord-010092-uftc8inx 6235 28 antioxidanttreated antioxidanttreated JJ cord-010092-uftc8inx 6235 29 group group NN cord-010092-uftc8inx 6235 30 . . . cord-010092-uftc8inx 6236 1 As as IN cord-010092-uftc8inx 6236 2 expected expect VBN cord-010092-uftc8inx 6236 3 , , , cord-010092-uftc8inx 6236 4 the the DT cord-010092-uftc8inx 6236 5 pH ph NN cord-010092-uftc8inx 6236 6 , , , cord-010092-uftc8inx 6236 7 glucose glucose NN cord-010092-uftc8inx 6236 8 and and CC cord-010092-uftc8inx 6236 9 lactate lactate NN cord-010092-uftc8inx 6236 10 levels level NNS cord-010092-uftc8inx 6236 11 of of IN cord-010092-uftc8inx 6236 12 the the DT cord-010092-uftc8inx 6236 13 cold cold JJ cord-010092-uftc8inx 6236 14 platelets platelet NNS cord-010092-uftc8inx 6236 15 were be VBD cord-010092-uftc8inx 6236 16 maintained maintain VBN cord-010092-uftc8inx 6236 17 and and CC cord-010092-uftc8inx 6236 18 the the DT cord-010092-uftc8inx 6236 19 platelets platelet NNS cord-010092-uftc8inx 6236 20 at at IN cord-010092-uftc8inx 6236 21 room room NN cord-010092-uftc8inx 6236 22 temperature temperature NN cord-010092-uftc8inx 6236 23 changed change VBD cord-010092-uftc8inx 6236 24 significantly significantly RB cord-010092-uftc8inx 6236 25 . . . cord-010092-uftc8inx 6237 1 NAC NAC NNP cord-010092-uftc8inx 6237 2 ( ( -LRB- cord-010092-uftc8inx 6237 3 N n CD cord-010092-uftc8inx 6237 4 - - HYPH cord-010092-uftc8inx 6237 5 acetylcysteine acetylcysteine NN cord-010092-uftc8inx 6237 6 ) ) -RRB- cord-010092-uftc8inx 6238 1 -treated -treated JJ cord-010092-uftc8inx 6238 2 platelets platelet NNS cord-010092-uftc8inx 6238 3 were be VBD cord-010092-uftc8inx 6238 4 less less RBR cord-010092-uftc8inx 6238 5 active active JJ cord-010092-uftc8inx 6238 6 on on IN cord-010092-uftc8inx 6238 7 day day NN cord-010092-uftc8inx 6238 8 12 12 CD cord-010092-uftc8inx 6238 9 and and CC cord-010092-uftc8inx 6238 10 sialidase sialidase NN cord-010092-uftc8inx 6238 11 activity activity NN cord-010092-uftc8inx 6238 12 was be VBD cord-010092-uftc8inx 6238 13 maintained maintain VBN cord-010092-uftc8inx 6238 14 lower low JJR cord-010092-uftc8inx 6238 15 than than IN cord-010092-uftc8inx 6238 16 that that DT cord-010092-uftc8inx 6238 17 of of IN cord-010092-uftc8inx 6238 18 control control NN cord-010092-uftc8inx 6238 19 group group NN cord-010092-uftc8inx 6238 20 on on IN cord-010092-uftc8inx 6238 21 day day NN cord-010092-uftc8inx 6238 22 12 12 CD cord-010092-uftc8inx 6238 23 . . . cord-010092-uftc8inx 6239 1 The the DT cord-010092-uftc8inx 6239 2 degree degree NN cord-010092-uftc8inx 6239 3 of of IN cord-010092-uftc8inx 6239 4 phagocytosis phagocytosis NN cord-010092-uftc8inx 6239 5 by by IN cord-010092-uftc8inx 6239 6 the the DT cord-010092-uftc8inx 6239 7 HEPG2 HEPG2 NNP cord-010092-uftc8inx 6239 8 cell cell NN cord-010092-uftc8inx 6239 9 line line NN cord-010092-uftc8inx 6239 10 remained remain VBD cord-010092-uftc8inx 6239 11 at at IN cord-010092-uftc8inx 6239 12 the the DT cord-010092-uftc8inx 6239 13 same same JJ cord-010092-uftc8inx 6239 14 level level NN cord-010092-uftc8inx 6239 15 during during IN cord-010092-uftc8inx 6239 16 the the DT cord-010092-uftc8inx 6239 17 storage storage NN cord-010092-uftc8inx 6239 18 period period NN cord-010092-uftc8inx 6239 19 , , , cord-010092-uftc8inx 6239 20 and and CC cord-010092-uftc8inx 6239 21 the the DT cord-010092-uftc8inx 6239 22 in in IN cord-010092-uftc8inx 6239 23 vivo vivo NN cord-010092-uftc8inx 6239 24 recovery recovery NN cord-010092-uftc8inx 6239 25 rate rate NN cord-010092-uftc8inx 6239 26 in in IN cord-010092-uftc8inx 6239 27 the the DT cord-010092-uftc8inx 6239 28 animal animal NN cord-010092-uftc8inx 6239 29 model model NN cord-010092-uftc8inx 6239 30 was be VBD cord-010092-uftc8inx 6239 31 superior superior JJ cord-010092-uftc8inx 6239 32 to to IN cord-010092-uftc8inx 6239 33 that that DT cord-010092-uftc8inx 6239 34 of of IN cord-010092-uftc8inx 6239 35 the the DT cord-010092-uftc8inx 6239 36 antioxidanttreated antioxidanttreated JJ cord-010092-uftc8inx 6239 37 cold cold JJ cord-010092-uftc8inx 6239 38 platelets platelet NNS cord-010092-uftc8inx 6239 39 for for IN cord-010092-uftc8inx 6239 40 2 2 CD cord-010092-uftc8inx 6239 41 h h NN cord-010092-uftc8inx 6239 42 and and CC cord-010092-uftc8inx 6239 43 24 24 CD cord-010092-uftc8inx 6239 44 h h NN cord-010092-uftc8inx 6239 45 after after IN cord-010092-uftc8inx 6239 46 transfusion transfusion NN cord-010092-uftc8inx 6239 47 . . . cord-010092-uftc8inx 6240 1 Summary Summary NNP cord-010092-uftc8inx 6240 2 / / SYM cord-010092-uftc8inx 6240 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 6240 4 : : : cord-010092-uftc8inx 6241 1 Cold cold JJ cord-010092-uftc8inx 6241 2 platelets platelet NNS cord-010092-uftc8inx 6241 3 could could MD cord-010092-uftc8inx 6241 4 be be VB cord-010092-uftc8inx 6241 5 developed develop VBN cord-010092-uftc8inx 6241 6 as as IN cord-010092-uftc8inx 6241 7 clinically clinically RB cord-010092-uftc8inx 6241 8 effective effective JJ cord-010092-uftc8inx 6241 9 agents agent NNS cord-010092-uftc8inx 6241 10 for for IN cord-010092-uftc8inx 6241 11 up up IN cord-010092-uftc8inx 6241 12 to to TO cord-010092-uftc8inx 6241 13 two two CD cord-010092-uftc8inx 6241 14 weeks week NNS cord-010092-uftc8inx 6241 15 if if IN cord-010092-uftc8inx 6241 16 appropriate appropriate JJ cord-010092-uftc8inx 6241 17 preservatives preservative NNS cord-010092-uftc8inx 6241 18 were be VBD cord-010092-uftc8inx 6241 19 added add VBN cord-010092-uftc8inx 6241 20 , , , cord-010092-uftc8inx 6241 21 and and CC cord-010092-uftc8inx 6241 22 antioxidants antioxidant NNS cord-010092-uftc8inx 6241 23 , , , cord-010092-uftc8inx 6241 24 especially especially RB cord-010092-uftc8inx 6241 25 N n NN cord-010092-uftc8inx 6241 26 - - HYPH cord-010092-uftc8inx 6241 27 acetylcysteine acetylcysteine NN cord-010092-uftc8inx 6241 28 , , , cord-010092-uftc8inx 6241 29 were be VBD cord-010092-uftc8inx 6241 30 effective effective JJ cord-010092-uftc8inx 6241 31 . . . cord-010092-uftc8inx 6242 1 Background background NN cord-010092-uftc8inx 6242 2 : : : cord-010092-uftc8inx 6243 1 The the DT cord-010092-uftc8inx 6243 2 Reveos Reveos NNP cord-010092-uftc8inx 6243 3 3C 3c NN cord-010092-uftc8inx 6243 4 procedure procedure NN cord-010092-uftc8inx 6243 5 produces produce VBZ cord-010092-uftc8inx 6243 6 the the DT cord-010092-uftc8inx 6243 7 following following JJ cord-010092-uftc8inx 6243 8 three three CD cord-010092-uftc8inx 6243 9 blood blood NN cord-010092-uftc8inx 6243 10 components component NNS cord-010092-uftc8inx 6243 11 for for IN cord-010092-uftc8inx 6243 12 transfusion transfusion NN cord-010092-uftc8inx 6243 13 : : : cord-010092-uftc8inx 6243 14 plasma plasma NN cord-010092-uftc8inx 6243 15 , , , cord-010092-uftc8inx 6243 16 RBCs rbc NNS cord-010092-uftc8inx 6243 17 , , , cord-010092-uftc8inx 6243 18 and and CC cord-010092-uftc8inx 6243 19 a a DT cord-010092-uftc8inx 6243 20 single single JJ cord-010092-uftc8inx 6243 21 interim interim JJ cord-010092-uftc8inx 6243 22 platelet platelet NN cord-010092-uftc8inx 6243 23 unit unit NN cord-010092-uftc8inx 6243 24 ( ( -LRB- cord-010092-uftc8inx 6243 25 IPU IPU NNP cord-010092-uftc8inx 6243 26 ) ) -RRB- cord-010092-uftc8inx 6243 27 . . . cord-010092-uftc8inx 6244 1 Whole whole JJ cord-010092-uftc8inx 6244 2 blood blood NN cord-010092-uftc8inx 6244 3 is be VBZ cord-010092-uftc8inx 6244 4 collected collect VBN cord-010092-uftc8inx 6244 5 into into IN cord-010092-uftc8inx 6244 6 the the DT cord-010092-uftc8inx 6244 7 Reveos Reveos NNP cord-010092-uftc8inx 6244 8 Blood Blood NNP cord-010092-uftc8inx 6244 9 Bag Bag NNP cord-010092-uftc8inx 6244 10 Set Set NNP cord-010092-uftc8inx 6244 11 and and CC cord-010092-uftc8inx 6244 12 held hold VBN cord-010092-uftc8inx 6244 13 at at IN cord-010092-uftc8inx 6244 14 room room NN cord-010092-uftc8inx 6244 15 temperature temperature NN cord-010092-uftc8inx 6244 16 a a DT cord-010092-uftc8inx 6244 17 minimum minimum NN cord-010092-uftc8inx 6244 18 of of IN cord-010092-uftc8inx 6244 19 2 2 CD cord-010092-uftc8inx 6244 20 h h NN cord-010092-uftc8inx 6244 21 before before IN cord-010092-uftc8inx 6244 22 processing process VBG cord-010092-uftc8inx 6244 23 on on IN cord-010092-uftc8inx 6244 24 the the DT cord-010092-uftc8inx 6244 25 device device NN cord-010092-uftc8inx 6244 26 . . . cord-010092-uftc8inx 6245 1 After after IN cord-010092-uftc8inx 6245 2 processing process VBG cord-010092-uftc8inx 6245 3 on on IN cord-010092-uftc8inx 6245 4 the the DT cord-010092-uftc8inx 6245 5 Reveos Reveos NNP cord-010092-uftc8inx 6245 6 device device NN cord-010092-uftc8inx 6245 7 , , , cord-010092-uftc8inx 6245 8 the the DT cord-010092-uftc8inx 6245 9 plasma plasma NN cord-010092-uftc8inx 6245 10 product product NN cord-010092-uftc8inx 6245 11 is be VBZ cord-010092-uftc8inx 6245 12 ready ready JJ cord-010092-uftc8inx 6245 13 to to TO cord-010092-uftc8inx 6245 14 freeze freeze VB cord-010092-uftc8inx 6245 15 . . . cord-010092-uftc8inx 6246 1 The the DT cord-010092-uftc8inx 6246 2 RBC RBC NNP cord-010092-uftc8inx 6246 3 product product NN cord-010092-uftc8inx 6246 4 is be VBZ cord-010092-uftc8inx 6246 5 ready ready JJ cord-010092-uftc8inx 6246 6 to to TO cord-010092-uftc8inx 6246 7 combine combine VB cord-010092-uftc8inx 6246 8 with with IN cord-010092-uftc8inx 6246 9 SAG SAG NNP cord-010092-uftc8inx 6246 10 - - HYPH cord-010092-uftc8inx 6246 11 M M NNP cord-010092-uftc8inx 6246 12 additive additive NN cord-010092-uftc8inx 6246 13 solution solution NN cord-010092-uftc8inx 6246 14 and and CC cord-010092-uftc8inx 6246 15 leukoreduce leukoreduce NN cord-010092-uftc8inx 6246 16 using use VBG cord-010092-uftc8inx 6246 17 the the DT cord-010092-uftc8inx 6246 18 integrated integrate VBN cord-010092-uftc8inx 6246 19 leukoreduction leukoreduction NN cord-010092-uftc8inx 6246 20 filter filter NN cord-010092-uftc8inx 6246 21 . . . cord-010092-uftc8inx 6247 1 The the DT cord-010092-uftc8inx 6247 2 IPUs ipu NNS cord-010092-uftc8inx 6247 3 are be VBP cord-010092-uftc8inx 6247 4 rested rest VBN cord-010092-uftc8inx 6247 5 and and CC cord-010092-uftc8inx 6247 6 agitated agitate VBN cord-010092-uftc8inx 6247 7 for for IN cord-010092-uftc8inx 6247 8 the the DT cord-010092-uftc8inx 6247 9 recommended recommend VBN cord-010092-uftc8inx 6247 10 time time NN cord-010092-uftc8inx 6247 11 . . . cord-010092-uftc8inx 6248 1 For for IN cord-010092-uftc8inx 6248 2 example example NN cord-010092-uftc8inx 6248 3 , , , cord-010092-uftc8inx 6248 4 when when WRB cord-010092-uftc8inx 6248 5 whole whole JJ cord-010092-uftc8inx 6248 6 blood blood NN cord-010092-uftc8inx 6248 7 is be VBZ cord-010092-uftc8inx 6248 8 processed process VBN cord-010092-uftc8inx 6248 9 within within IN cord-010092-uftc8inx 6248 10 8 8 CD cord-010092-uftc8inx 6248 11 h h NN cord-010092-uftc8inx 6248 12 of of IN cord-010092-uftc8inx 6248 13 collection collection NN cord-010092-uftc8inx 6248 14 , , , cord-010092-uftc8inx 6248 15 the the DT cord-010092-uftc8inx 6248 16 IPU IPU NNP cord-010092-uftc8inx 6248 17 is be VBZ cord-010092-uftc8inx 6248 18 agitated agitate VBN cord-010092-uftc8inx 6248 19 overnight overnight RB cord-010092-uftc8inx 6248 20 before before IN cord-010092-uftc8inx 6248 21 pooling pool VBG cord-010092-uftc8inx 6248 22 . . . cord-010092-uftc8inx 6249 1 Because because IN cord-010092-uftc8inx 6249 2 the the DT cord-010092-uftc8inx 6249 3 IPU IPU NNP cord-010092-uftc8inx 6249 4 is be VBZ cord-010092-uftc8inx 6249 5 made make VBN cord-010092-uftc8inx 6249 6 from from IN cord-010092-uftc8inx 6249 7 one one CD cord-010092-uftc8inx 6249 8 unit unit NN cord-010092-uftc8inx 6249 9 of of IN cord-010092-uftc8inx 6249 10 whole whole JJ cord-010092-uftc8inx 6249 11 blood blood NN cord-010092-uftc8inx 6249 12 , , , cord-010092-uftc8inx 6249 13 approximately approximately RB cord-010092-uftc8inx 6249 14 4 4 CD cord-010092-uftc8inx 6249 15 to to TO cord-010092-uftc8inx 6249 16 6 6 CD cord-010092-uftc8inx 6249 17 IPUs ipu NNS cord-010092-uftc8inx 6249 18 are be VBP cord-010092-uftc8inx 6249 19 pooled pool VBN cord-010092-uftc8inx 6249 20 together together RB cord-010092-uftc8inx 6249 21 and and CC cord-010092-uftc8inx 6249 22 leukoreduced leukoreduce VBN cord-010092-uftc8inx 6249 23 by by IN cord-010092-uftc8inx 6249 24 filtration filtration NN cord-010092-uftc8inx 6249 25 prior prior RB cord-010092-uftc8inx 6249 26 to to IN cord-010092-uftc8inx 6249 27 storage storage NN cord-010092-uftc8inx 6249 28 in in IN cord-010092-uftc8inx 6249 29 a a DT cord-010092-uftc8inx 6249 30 platelet platelet NN cord-010092-uftc8inx 6249 31 storage storage NN cord-010092-uftc8inx 6249 32 bag bag NN cord-010092-uftc8inx 6249 33 . . . cord-010092-uftc8inx 6250 1 This this DT cord-010092-uftc8inx 6250 2 leukoreduced leukoreduced JJ cord-010092-uftc8inx 6250 3 platelet platelet NN cord-010092-uftc8inx 6250 4 pool pool NN cord-010092-uftc8inx 6250 5 ( ( -LRB- cord-010092-uftc8inx 6250 6 4 4 CD cord-010092-uftc8inx 6250 7 units unit NNS cord-010092-uftc8inx 6250 8 ) ) -RRB- cord-010092-uftc8inx 6250 9 can can MD cord-010092-uftc8inx 6250 10 be be VB cord-010092-uftc8inx 6250 11 supplied supply VBN cord-010092-uftc8inx 6250 12 to to IN cord-010092-uftc8inx 6250 13 the the DT cord-010092-uftc8inx 6250 14 demand demand NN cord-010092-uftc8inx 6250 15 of of IN cord-010092-uftc8inx 6250 16 hospitals hospital NNS cord-010092-uftc8inx 6250 17 like like IN cord-010092-uftc8inx 6250 18 a a DT cord-010092-uftc8inx 6250 19 Platelet platelet NN cord-010092-uftc8inx 6250 20 apheresis apheresis NN cord-010092-uftc8inx 6250 21 product product NN cord-010092-uftc8inx 6250 22 . . . cord-010092-uftc8inx 6251 1 Aims aim VBZ cord-010092-uftc8inx 6251 2 : : : cord-010092-uftc8inx 6251 3 To to TO cord-010092-uftc8inx 6251 4 assess assess VB cord-010092-uftc8inx 6251 5 the the DT cord-010092-uftc8inx 6251 6 usability usability NN cord-010092-uftc8inx 6251 7 of of IN cord-010092-uftc8inx 6251 8 the the DT cord-010092-uftc8inx 6251 9 Reveos Reveos NNP cord-010092-uftc8inx 6251 10 Automated Automated NNP cord-010092-uftc8inx 6251 11 Blood Blood NNP cord-010092-uftc8inx 6251 12 Processing Processing NNP cord-010092-uftc8inx 6251 13 System System NNP cord-010092-uftc8inx 6251 14 to to TO cord-010092-uftc8inx 6251 15 collect collect VB cord-010092-uftc8inx 6251 16 units unit NNS cord-010092-uftc8inx 6251 17 of of IN cord-010092-uftc8inx 6251 18 whole whole JJ cord-010092-uftc8inx 6251 19 blood blood NN cord-010092-uftc8inx 6251 20 and and CC cord-010092-uftc8inx 6251 21 to to TO cord-010092-uftc8inx 6251 22 process process VB cord-010092-uftc8inx 6251 23 the the DT cord-010092-uftc8inx 6251 24 units unit NNS cord-010092-uftc8inx 6251 25 on on IN cord-010092-uftc8inx 6251 26 the the DT cord-010092-uftc8inx 6251 27 Reveos Reveos NNP cord-010092-uftc8inx 6251 28 device device NN cord-010092-uftc8inx 6251 29 , , , cord-010092-uftc8inx 6251 30 producing produce VBG cord-010092-uftc8inx 6251 31 blood blood NN cord-010092-uftc8inx 6251 32 components component NNS cord-010092-uftc8inx 6251 33 that that WDT cord-010092-uftc8inx 6251 34 meet meet VBP cord-010092-uftc8inx 6251 35 product product NN cord-010092-uftc8inx 6251 36 quality quality NN cord-010092-uftc8inx 6251 37 specifications specification NNS cord-010092-uftc8inx 6251 38 . . . cord-010092-uftc8inx 6252 1 Methods method NNS cord-010092-uftc8inx 6252 2 : : : cord-010092-uftc8inx 6252 3 This this DT cord-010092-uftc8inx 6252 4 study study NN cord-010092-uftc8inx 6252 5 will will MD cord-010092-uftc8inx 6252 6 evaluate evaluate VB cord-010092-uftc8inx 6252 7 approximately approximately RB cord-010092-uftc8inx 6252 8 19 19 CD cord-010092-uftc8inx 6252 9 units unit NNS cord-010092-uftc8inx 6252 10 of of IN cord-010092-uftc8inx 6252 11 whole whole JJ cord-010092-uftc8inx 6252 12 blood blood NN cord-010092-uftc8inx 6252 13 using use VBG cord-010092-uftc8inx 6252 14 the the DT cord-010092-uftc8inx 6252 15 Reveos Reveos NNP cord-010092-uftc8inx 6252 16 system system NN cord-010092-uftc8inx 6252 17 and and CC cord-010092-uftc8inx 6252 18 approximately approximately RB cord-010092-uftc8inx 6252 19 4 4 CD cord-010092-uftc8inx 6252 20 units unit NNS cord-010092-uftc8inx 6252 21 of of IN cord-010092-uftc8inx 6252 22 pooled pool VBN cord-010092-uftc8inx 6252 23 platelet platelet NN cord-010092-uftc8inx 6252 24 products product NNS cord-010092-uftc8inx 6252 25 . . . cord-010092-uftc8inx 6253 1 A a DT cord-010092-uftc8inx 6253 2 total total NN cord-010092-uftc8inx 6253 3 of of IN cord-010092-uftc8inx 6253 4 19 19 CD cord-010092-uftc8inx 6253 5 units unit NNS cord-010092-uftc8inx 6253 6 of of IN cord-010092-uftc8inx 6253 7 whole whole JJ cord-010092-uftc8inx 6253 8 blood blood NN cord-010092-uftc8inx 6253 9 ( ( -LRB- cord-010092-uftc8inx 6253 10 WB WB NNP cord-010092-uftc8inx 6253 11 ) ) -RRB- cord-010092-uftc8inx 6253 12 have have VBP cord-010092-uftc8inx 6253 13 been be VBN cord-010092-uftc8inx 6253 14 collected collect VBN cord-010092-uftc8inx 6253 15 into into IN cord-010092-uftc8inx 6253 16 the the DT cord-010092-uftc8inx 6253 17 Reveos Reveos NNP cord-010092-uftc8inx 6253 18 blood blood NN cord-010092-uftc8inx 6253 19 bag bag NN cord-010092-uftc8inx 6253 20 set set VBN cord-010092-uftc8inx 6253 21 and and CC cord-010092-uftc8inx 6253 22 then then RB cord-010092-uftc8inx 6253 23 held hold VBN cord-010092-uftc8inx 6253 24 at at IN cord-010092-uftc8inx 6253 25 room room NN cord-010092-uftc8inx 6253 26 temperature temperature NN cord-010092-uftc8inx 6253 27 without without IN cord-010092-uftc8inx 6253 28 the the DT cord-010092-uftc8inx 6253 29 use use NN cord-010092-uftc8inx 6253 30 of of IN cord-010092-uftc8inx 6253 31 an an DT cord-010092-uftc8inx 6253 32 active active JJ cord-010092-uftc8inx 6253 33 cooling cooling NN cord-010092-uftc8inx 6253 34 system system NN cord-010092-uftc8inx 6253 35 ( ( -LRB- cord-010092-uftc8inx 6253 36 or or CC cord-010092-uftc8inx 6253 37 temperature temperature NN cord-010092-uftc8inx 6253 38 control control NN cord-010092-uftc8inx 6253 39 system system NN cord-010092-uftc8inx 6253 40 ) ) -RRB- cord-010092-uftc8inx 6253 41 , , , cord-010092-uftc8inx 6253 42 such such JJ cord-010092-uftc8inx 6253 43 as as IN cord-010092-uftc8inx 6253 44 cooling cool VBG cord-010092-uftc8inx 6253 45 plates plate NNS cord-010092-uftc8inx 6253 46 , , , cord-010092-uftc8inx 6253 47 or or CC cord-010092-uftc8inx 6253 48 in in IN cord-010092-uftc8inx 6253 49 this this DT cord-010092-uftc8inx 6253 50 case case NN cord-010092-uftc8inx 6253 51 , , , cord-010092-uftc8inx 6253 52 ice ice NN cord-010092-uftc8inx 6253 53 packs pack NNS cord-010092-uftc8inx 6253 54 . . . cord-010092-uftc8inx 6254 1 Of of IN cord-010092-uftc8inx 6254 2 the the DT cord-010092-uftc8inx 6254 3 19 19 CD cord-010092-uftc8inx 6254 4 units unit NNS cord-010092-uftc8inx 6254 5 , , , cord-010092-uftc8inx 6254 6 10 10 CD cord-010092-uftc8inx 6254 7 units unit NNS cord-010092-uftc8inx 6254 8 have have VBP cord-010092-uftc8inx 6254 9 been be VBN cord-010092-uftc8inx 6254 10 processed process VBN cord-010092-uftc8inx 6254 11 on on IN cord-010092-uftc8inx 6254 12 the the DT cord-010092-uftc8inx 6254 13 Reveos Reveos NNP cord-010092-uftc8inx 6254 14 device device NN cord-010092-uftc8inx 6254 15 using use VBG cord-010092-uftc8inx 6254 16 the the DT cord-010092-uftc8inx 6254 17 fresh fresh JJ cord-010092-uftc8inx 6254 18 procedure procedure NN cord-010092-uftc8inx 6254 19 ( ( -LRB- cord-010092-uftc8inx 6254 20 within within IN cord-010092-uftc8inx 6254 21 8 8 CD cord-010092-uftc8inx 6254 22 h h NN cord-010092-uftc8inx 6254 23 of of IN cord-010092-uftc8inx 6254 24 collection collection NN cord-010092-uftc8inx 6254 25 ) ) -RRB- cord-010092-uftc8inx 6254 26 . . . cord-010092-uftc8inx 6255 1 Nine nine CD cord-010092-uftc8inx 6255 2 units unit NNS cord-010092-uftc8inx 6255 3 have have VBP cord-010092-uftc8inx 6255 4 been be VBN cord-010092-uftc8inx 6255 5 processed process VBN cord-010092-uftc8inx 6255 6 using use VBG cord-010092-uftc8inx 6255 7 the the DT cord-010092-uftc8inx 6255 8 overnight overnight JJ cord-010092-uftc8inx 6255 9 WBhold wbhold JJ cord-010092-uftc8inx 6255 10 procedure procedure NN cord-010092-uftc8inx 6255 11 . . . cord-010092-uftc8inx 6256 1 All all DT cord-010092-uftc8inx 6256 2 units unit NNS cord-010092-uftc8inx 6256 3 have have VBP cord-010092-uftc8inx 6256 4 processed process VBN cord-010092-uftc8inx 6256 5 successfully successfully RB cord-010092-uftc8inx 6256 6 without without IN cord-010092-uftc8inx 6256 7 alarms alarm NNS cord-010092-uftc8inx 6256 8 , , , cord-010092-uftc8inx 6256 9 resulting result VBG cord-010092-uftc8inx 6256 10 in in IN cord-010092-uftc8inx 6256 11 three three CD cord-010092-uftc8inx 6256 12 components component NNS cord-010092-uftc8inx 6256 13 ( ( -LRB- cord-010092-uftc8inx 6256 14 RBCs rbc NNS cord-010092-uftc8inx 6256 15 , , , cord-010092-uftc8inx 6256 16 Plasma plasma NN cord-010092-uftc8inx 6256 17 , , , cord-010092-uftc8inx 6256 18 Platelets Platelets NNP cord-010092-uftc8inx 6256 19 ) ) -RRB- cord-010092-uftc8inx 6256 20 . . . cord-010092-uftc8inx 6257 1 We -PRON- PRP cord-010092-uftc8inx 6257 2 also also RB cord-010092-uftc8inx 6257 3 evaluated evaluate VBD cord-010092-uftc8inx 6257 4 four four CD cord-010092-uftc8inx 6257 5 platelet platelet NN cord-010092-uftc8inx 6257 6 pools pool NNS cord-010092-uftc8inx 6257 7 created create VBN cord-010092-uftc8inx 6257 8 from from IN cord-010092-uftc8inx 6257 9 eighteen eighteen CD cord-010092-uftc8inx 6257 10 interim interim JJ cord-010092-uftc8inx 6257 11 platelet platelet NN cord-010092-uftc8inx 6257 12 units unit NNS cord-010092-uftc8inx 6257 13 ( ( -LRB- cord-010092-uftc8inx 6257 14 IPUs ipu NNS cord-010092-uftc8inx 6257 15 ) ) -RRB- cord-010092-uftc8inx 6257 16 . . . cord-010092-uftc8inx 6258 1 One one CD cord-010092-uftc8inx 6258 2 IPU IPU NNP cord-010092-uftc8inx 6258 3 has have VBZ cord-010092-uftc8inx 6258 4 been be VBN cord-010092-uftc8inx 6258 5 discarded discard VBN cord-010092-uftc8inx 6258 6 due due IN cord-010092-uftc8inx 6258 7 to to IN cord-010092-uftc8inx 6258 8 a a DT cord-010092-uftc8inx 6258 9 22-min 22-min CD cord-010092-uftc8inx 6258 10 whole whole JJ cord-010092-uftc8inx 6258 11 blood blood NN cord-010092-uftc8inx 6258 12 collection collection NN cord-010092-uftc8inx 6258 13 time time NN cord-010092-uftc8inx 6258 14 . . . cord-010092-uftc8inx 6259 1 The the DT cord-010092-uftc8inx 6259 2 leukocyte leukocyte NN cord-010092-uftc8inx 6259 3 count count NN cord-010092-uftc8inx 6259 4 on on IN cord-010092-uftc8inx 6259 5 all all DT cord-010092-uftc8inx 6259 6 component component NN cord-010092-uftc8inx 6259 7 using use VBG cord-010092-uftc8inx 6259 8 the the DT cord-010092-uftc8inx 6259 9 automatic automatic JJ cord-010092-uftc8inx 6259 10 Sysmex Sysmex NNP cord-010092-uftc8inx 6259 11 - - HYPH cord-010092-uftc8inx 6259 12 XN XN NNP cord-010092-uftc8inx 6259 13 2000 2000 CD cord-010092-uftc8inx 6259 14 cell cell NN cord-010092-uftc8inx 6259 15 blood blood NN cord-010092-uftc8inx 6259 16 counter counter NN cord-010092-uftc8inx 6259 17 . . . cord-010092-uftc8inx 6260 1 Results result NNS cord-010092-uftc8inx 6260 2 : : : cord-010092-uftc8inx 6261 1 The the DT cord-010092-uftc8inx 6261 2 Red Red NNP cord-010092-uftc8inx 6261 3 Blood Blood NNP cord-010092-uftc8inx 6261 4 Cells cell NNS cord-010092-uftc8inx 6261 5 meet meet VBP cord-010092-uftc8inx 6261 6 the the DT cord-010092-uftc8inx 6261 7 criteria criterion NNS cord-010092-uftc8inx 6261 8 for for IN cord-010092-uftc8inx 6261 9 hematocrit hematocrit NN cord-010092-uftc8inx 6261 10 , , , cord-010092-uftc8inx 6261 11 hemoglobin hemoglobin NN cord-010092-uftc8inx 6261 12 and and CC cord-010092-uftc8inx 6261 13 residual residual JJ cord-010092-uftc8inx 6261 14 WBC WBC NNP cord-010092-uftc8inx 6261 15 counts count NNS cord-010092-uftc8inx 6261 16 are be VBP cord-010092-uftc8inx 6261 17 less less JJR cord-010092-uftc8inx 6261 18 than than IN cord-010092-uftc8inx 6261 19 1 1 CD cord-010092-uftc8inx 6261 20 million million CD cord-010092-uftc8inx 6261 21 per per IN cord-010092-uftc8inx 6261 22 unit unit NN cord-010092-uftc8inx 6261 23 . . . cord-010092-uftc8inx 6262 1 The the DT cord-010092-uftc8inx 6262 2 Plasma Plasma NNP cord-010092-uftc8inx 6262 3 units unit NNS cord-010092-uftc8inx 6262 4 meet meet VBP cord-010092-uftc8inx 6262 5 the the DT cord-010092-uftc8inx 6262 6 criteria criterion NNS cord-010092-uftc8inx 6262 7 for for IN cord-010092-uftc8inx 6262 8 displayed display VBN cord-010092-uftc8inx 6262 9 volume volume NN cord-010092-uftc8inx 6262 10 accuracy accuracy NN cord-010092-uftc8inx 6262 11 compared compare VBN cord-010092-uftc8inx 6262 12 to to IN cord-010092-uftc8inx 6262 13 measured measure VBN cord-010092-uftc8inx 6262 14 volume volume NN cord-010092-uftc8inx 6262 15 and and CC cord-010092-uftc8inx 6262 16 also also RB cord-010092-uftc8inx 6262 17 for for IN cord-010092-uftc8inx 6262 18 Factor factor NN cord-010092-uftc8inx 6262 19 VIII VIII NNP cord-010092-uftc8inx 6262 20 levels level NNS cord-010092-uftc8inx 6262 21 . . . cord-010092-uftc8inx 6263 1 The the DT cord-010092-uftc8inx 6263 2 average average JJ cord-010092-uftc8inx 6263 3 residual residual JJ cord-010092-uftc8inx 6263 4 platelets platelet NNS cord-010092-uftc8inx 6263 5 in in IN cord-010092-uftc8inx 6263 6 plasma plasma NN cord-010092-uftc8inx 6263 7 levels level NNS cord-010092-uftc8inx 6263 8 meet meet VBP cord-010092-uftc8inx 6263 9 the the DT cord-010092-uftc8inx 6263 10 criteria criterion NNS cord-010092-uftc8inx 6263 11 . . . cord-010092-uftc8inx 6264 1 The the DT cord-010092-uftc8inx 6264 2 platelet platelet NN cord-010092-uftc8inx 6264 3 pools pool NNS cord-010092-uftc8inx 6264 4 meet meet VBP cord-010092-uftc8inx 6264 5 the the DT cord-010092-uftc8inx 6264 6 acceptance acceptance NN cord-010092-uftc8inx 6264 7 criteria criterion NNS cord-010092-uftc8inx 6264 8 for for IN cord-010092-uftc8inx 6264 9 platelet platelet NN cord-010092-uftc8inx 6264 10 yield yield NN cord-010092-uftc8inx 6264 11 and and CC cord-010092-uftc8inx 6264 12 volume volume NN cord-010092-uftc8inx 6264 13 . . . cord-010092-uftc8inx 6265 1 Limited limited JJ cord-010092-uftc8inx 6265 2 data datum NNS cord-010092-uftc8inx 6265 3 ( ( -LRB- cord-010092-uftc8inx 6265 4 n n NN cord-010092-uftc8inx 6265 5 = = SYM cord-010092-uftc8inx 6265 6 4 4 CD cord-010092-uftc8inx 6265 7 ) ) -RRB- cord-010092-uftc8inx 6265 8 suggests suggest VBZ cord-010092-uftc8inx 6265 9 that that IN cord-010092-uftc8inx 6265 10 this this DT cord-010092-uftc8inx 6265 11 criteria criterion NNS cord-010092-uftc8inx 6265 12 will will MD cord-010092-uftc8inx 6265 13 be be VB cord-010092-uftc8inx 6265 14 easily easily RB cord-010092-uftc8inx 6265 15 met meet VBN cord-010092-uftc8inx 6265 16 , , , cord-010092-uftc8inx 6265 17 provided provide VBN cord-010092-uftc8inx 6265 18 that that IN cord-010092-uftc8inx 6265 19 WB WB NNP cord-010092-uftc8inx 6265 20 hold hold NN cord-010092-uftc8inx 6265 21 conditions condition NNS cord-010092-uftc8inx 6265 22 are be VBP cord-010092-uftc8inx 6265 23 suitable suitable JJ cord-010092-uftc8inx 6265 24 for for IN cord-010092-uftc8inx 6265 25 platelets platelet NNS cord-010092-uftc8inx 6265 26 . . . cord-010092-uftc8inx 6266 1 Summary Summary NNP cord-010092-uftc8inx 6266 2 / / SYM cord-010092-uftc8inx 6266 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 6266 4 : : : cord-010092-uftc8inx 6267 1 Final final JJ cord-010092-uftc8inx 6267 2 results result NNS cord-010092-uftc8inx 6267 3 indicate indicate VBP cord-010092-uftc8inx 6267 4 that that IN cord-010092-uftc8inx 6267 5 products product NNS cord-010092-uftc8inx 6267 6 produced produce VBN cord-010092-uftc8inx 6267 7 from from IN cord-010092-uftc8inx 6267 8 the the DT cord-010092-uftc8inx 6267 9 Reveos Reveos NNP cord-010092-uftc8inx 6267 10 system system NN cord-010092-uftc8inx 6267 11 meet meet VBP cord-010092-uftc8inx 6267 12 or or CC cord-010092-uftc8inx 6267 13 exceed exceed VBP cord-010092-uftc8inx 6267 14 product product NN cord-010092-uftc8inx 6267 15 quality quality NN cord-010092-uftc8inx 6267 16 expectations expectation NNS cord-010092-uftc8inx 6267 17 . . . cord-010092-uftc8inx 6268 1 Staff staff NN cord-010092-uftc8inx 6268 2 report report VBP cord-010092-uftc8inx 6268 3 that that IN cord-010092-uftc8inx 6268 4 the the DT cord-010092-uftc8inx 6268 5 Reveos Reveos NNP cord-010092-uftc8inx 6268 6 system system NN cord-010092-uftc8inx 6268 7 is be VBZ cord-010092-uftc8inx 6268 8 very very RB cord-010092-uftc8inx 6268 9 easy easy JJ cord-010092-uftc8inx 6268 10 to to TO cord-010092-uftc8inx 6268 11 use use VB cord-010092-uftc8inx 6268 12 . . . cord-010092-uftc8inx 6269 1 Abstract Abstract NNP cord-010092-uftc8inx 6269 2 withdrawn withdraw VBN cord-010092-uftc8inx 6269 3 . . . cord-010092-uftc8inx 6270 1 Background background NN cord-010092-uftc8inx 6270 2 : : : cord-010092-uftc8inx 6271 1 Thorough thorough JJ cord-010092-uftc8inx 6271 2 manual manual JJ cord-010092-uftc8inx 6271 3 mixing mixing NN cord-010092-uftc8inx 6271 4 of of IN cord-010092-uftc8inx 6271 5 overnight overnight RB cord-010092-uftc8inx 6271 6 - - HYPH cord-010092-uftc8inx 6271 7 held hold VBN cord-010092-uftc8inx 6271 8 whole whole JJ cord-010092-uftc8inx 6271 9 blood blood NN cord-010092-uftc8inx 6271 10 ( ( -LRB- cord-010092-uftc8inx 6271 11 WB WB NNP cord-010092-uftc8inx 6271 12 ) ) -RRB- cord-010092-uftc8inx 6271 13 units unit NNS cord-010092-uftc8inx 6271 14 prior prior RB cord-010092-uftc8inx 6271 15 to to IN cord-010092-uftc8inx 6271 16 centrifugation centrifugation NN cord-010092-uftc8inx 6271 17 to to IN cord-010092-uftc8inx 6271 18 separate separate JJ cord-010092-uftc8inx 6271 19 red red JJ cord-010092-uftc8inx 6271 20 cell cell NN cord-010092-uftc8inx 6271 21 ( ( -LRB- cord-010092-uftc8inx 6271 22 RC RC NNP cord-010092-uftc8inx 6271 23 ) ) -RRB- cord-010092-uftc8inx 6271 24 from from IN cord-010092-uftc8inx 6271 25 platelet platelet NN cord-010092-uftc8inx 6271 26 - - HYPH cord-010092-uftc8inx 6271 27 rich rich JJ cord-010092-uftc8inx 6271 28 - - HYPH cord-010092-uftc8inx 6271 29 plasma plasma NN cord-010092-uftc8inx 6271 30 ( ( -LRB- cord-010092-uftc8inx 6271 31 PRP prp NN cord-010092-uftc8inx 6271 32 ) ) -RRB- cord-010092-uftc8inx 6271 33 is be VBZ cord-010092-uftc8inx 6271 34 currently currently RB cord-010092-uftc8inx 6271 35 practised practise VBN cord-010092-uftc8inx 6271 36 at at IN cord-010092-uftc8inx 6271 37 the the DT cord-010092-uftc8inx 6271 38 Hong Hong NNP cord-010092-uftc8inx 6271 39 Kong Kong NNP cord-010092-uftc8inx 6271 40 Red Red NNP cord-010092-uftc8inx 6271 41 Cross Cross NNP cord-010092-uftc8inx 6271 42 Blood Blood NNP cord-010092-uftc8inx 6271 43 Transfusion Transfusion NNP cord-010092-uftc8inx 6271 44 Service Service NNP cord-010092-uftc8inx 6271 45 ( ( -LRB- cord-010092-uftc8inx 6271 46 HKRCBTS HKRCBTS NNP cord-010092-uftc8inx 6271 47 ) ) -RRB- cord-010092-uftc8inx 6271 48 . . . cord-010092-uftc8inx 6272 1 The the DT cord-010092-uftc8inx 6272 2 mixing mix VBG cord-010092-uftc8inx 6272 3 step step NN cord-010092-uftc8inx 6272 4 is be VBZ cord-010092-uftc8inx 6272 5 crucial crucial JJ cord-010092-uftc8inx 6272 6 to to TO cord-010092-uftc8inx 6272 7 maximise maximise VB cord-010092-uftc8inx 6272 8 platelet platelet NN cord-010092-uftc8inx 6272 9 yield yield NN cord-010092-uftc8inx 6272 10 but but CC cord-010092-uftc8inx 6272 11 laborious laborious JJ cord-010092-uftc8inx 6272 12 , , , cord-010092-uftc8inx 6272 13 and and CC cord-010092-uftc8inx 6272 14 may may MD cord-010092-uftc8inx 6272 15 cause cause VB cord-010092-uftc8inx 6272 16 elbow elbow NN cord-010092-uftc8inx 6272 17 and and CC cord-010092-uftc8inx 6272 18 wrist wrist NN cord-010092-uftc8inx 6272 19 injuries injury NNS cord-010092-uftc8inx 6272 20 in in IN cord-010092-uftc8inx 6272 21 operators operator NNS cord-010092-uftc8inx 6272 22 . . . cord-010092-uftc8inx 6273 1 A a DT cord-010092-uftc8inx 6273 2 laboratory laboratory NN cord-010092-uftc8inx 6273 3 shaker shaker NN cord-010092-uftc8inx 6273 4 , , , cord-010092-uftc8inx 6273 5 Reax Reax NNP cord-010092-uftc8inx 6273 6 20 20 CD cord-010092-uftc8inx 6274 1 ( ( -LRB- cord-010092-uftc8inx 6274 2 Heidolph Heidolph NNP cord-010092-uftc8inx 6274 3 Instruments Instruments NNP cord-010092-uftc8inx 6274 4 , , , cord-010092-uftc8inx 6274 5 Schwabach Schwabach NNP cord-010092-uftc8inx 6274 6 , , , cord-010092-uftc8inx 6274 7 Germany Germany NNP cord-010092-uftc8inx 6274 8 ) ) -RRB- cord-010092-uftc8inx 6274 9 , , , cord-010092-uftc8inx 6274 10 originally originally RB cord-010092-uftc8inx 6274 11 designed design VBN cord-010092-uftc8inx 6274 12 for for IN cord-010092-uftc8inx 6274 13 mixing mix VBG cord-010092-uftc8inx 6274 14 solvents solvent NNS cord-010092-uftc8inx 6274 15 , , , cord-010092-uftc8inx 6274 16 was be VBD cord-010092-uftc8inx 6274 17 modified modify VBN cord-010092-uftc8inx 6274 18 to to TO cord-010092-uftc8inx 6274 19 allow allow VB cord-010092-uftc8inx 6274 20 mixing mix VBG cord-010092-uftc8inx 6274 21 source source NN cord-010092-uftc8inx 6274 22 WB WB NNP cord-010092-uftc8inx 6274 23 units unit NNS cord-010092-uftc8inx 6274 24 by by IN cord-010092-uftc8inx 6274 25 the the DT cord-010092-uftc8inx 6274 26 supplier supplier NN cord-010092-uftc8inx 6274 27 . . . cord-010092-uftc8inx 6275 1 To to TO cord-010092-uftc8inx 6275 2 enhance enhance VB cord-010092-uftc8inx 6275 3 the the DT cord-010092-uftc8inx 6275 4 well well RB cord-010092-uftc8inx 6275 5 - - HYPH cord-010092-uftc8inx 6275 6 being being NN cord-010092-uftc8inx 6275 7 of of IN cord-010092-uftc8inx 6275 8 the the DT cord-010092-uftc8inx 6275 9 operators operator NNS cord-010092-uftc8inx 6275 10 in in IN cord-010092-uftc8inx 6275 11 the the DT cord-010092-uftc8inx 6275 12 context context NN cord-010092-uftc8inx 6275 13 of of IN cord-010092-uftc8inx 6275 14 occupation occupation NN cord-010092-uftc8inx 6275 15 health health NN cord-010092-uftc8inx 6275 16 and and CC cord-010092-uftc8inx 6275 17 safety safety NN cord-010092-uftc8inx 6275 18 ( ( -LRB- cord-010092-uftc8inx 6275 19 OH&S OH&S NNP cord-010092-uftc8inx 6275 20 ) ) -RRB- cord-010092-uftc8inx 6275 21 management management NN cord-010092-uftc8inx 6275 22 , , , cord-010092-uftc8inx 6275 23 feasibility feasibility NN cord-010092-uftc8inx 6275 24 of of IN cord-010092-uftc8inx 6275 25 the the DT cord-010092-uftc8inx 6275 26 application application NN cord-010092-uftc8inx 6275 27 of of IN cord-010092-uftc8inx 6275 28 such such JJ cord-010092-uftc8inx 6275 29 blood blood NN cord-010092-uftc8inx 6275 30 mixer mixer NN cord-010092-uftc8inx 6275 31 to to TO cord-010092-uftc8inx 6275 32 replace replace VB cord-010092-uftc8inx 6275 33 the the DT cord-010092-uftc8inx 6275 34 manual manual JJ cord-010092-uftc8inx 6275 35 mixing mix VBG cord-010092-uftc8inx 6275 36 steps step NNS cord-010092-uftc8inx 6275 37 in in IN cord-010092-uftc8inx 6275 38 blood blood NN cord-010092-uftc8inx 6275 39 component component NN cord-010092-uftc8inx 6275 40 preparation preparation NN cord-010092-uftc8inx 6275 41 was be VBD cord-010092-uftc8inx 6275 42 explored explore VBN cord-010092-uftc8inx 6275 43 . . . cord-010092-uftc8inx 6276 1 Aims aim VBZ cord-010092-uftc8inx 6276 2 : : : cord-010092-uftc8inx 6276 3 To to TO cord-010092-uftc8inx 6276 4 evaluate evaluate VB cord-010092-uftc8inx 6276 5 the the DT cord-010092-uftc8inx 6276 6 in in FW cord-010092-uftc8inx 6276 7 vitro vitro FW cord-010092-uftc8inx 6276 8 quality quality NN cord-010092-uftc8inx 6276 9 control control NN cord-010092-uftc8inx 6276 10 ( ( -LRB- cord-010092-uftc8inx 6276 11 QC QC NNP cord-010092-uftc8inx 6276 12 ) ) -RRB- cord-010092-uftc8inx 6276 13 parameters parameter NNS cord-010092-uftc8inx 6276 14 of of IN cord-010092-uftc8inx 6276 15 the the DT cord-010092-uftc8inx 6276 16 blood blood NN cord-010092-uftc8inx 6276 17 components component NNS cord-010092-uftc8inx 6276 18 prepared prepare VBN cord-010092-uftc8inx 6276 19 with with IN cord-010092-uftc8inx 6276 20 the the DT cord-010092-uftc8inx 6276 21 use use NN cord-010092-uftc8inx 6276 22 of of IN cord-010092-uftc8inx 6276 23 the the DT cord-010092-uftc8inx 6276 24 modified modify VBN cord-010092-uftc8inx 6276 25 mixer mixer NN cord-010092-uftc8inx 6276 26 . . . cord-010092-uftc8inx 6277 1 Methods method NNS cord-010092-uftc8inx 6277 2 : : : cord-010092-uftc8inx 6277 3 Fifty fifty CD cord-010092-uftc8inx 6277 4 - - HYPH cord-010092-uftc8inx 6277 5 eight eight CD cord-010092-uftc8inx 6277 6 WB WB NNP cord-010092-uftc8inx 6277 7 collections collection NNS cord-010092-uftc8inx 6277 8 , , , cord-010092-uftc8inx 6277 9 including include VBG cord-010092-uftc8inx 6277 10 40 40 CD cord-010092-uftc8inx 6277 11 units unit NNS cord-010092-uftc8inx 6277 12 in in IN cord-010092-uftc8inx 6277 13 450 450 CD cord-010092-uftc8inx 6277 14 mL ml NN cord-010092-uftc8inx 6277 15 quadruple quadruple JJ cord-010092-uftc8inx 6277 16 bags bag NNS cord-010092-uftc8inx 6277 17 ( ( -LRB- cord-010092-uftc8inx 6277 18 450Q 450q CD cord-010092-uftc8inx 6277 19 ) ) -RRB- cord-010092-uftc8inx 6277 20 with with IN cord-010092-uftc8inx 6277 21 / / SYM cord-010092-uftc8inx 6277 22 without without IN cord-010092-uftc8inx 6277 23 integrated integrate VBN cord-010092-uftc8inx 6277 24 leucofilter leucofilter NN cord-010092-uftc8inx 6277 25 and and CC cord-010092-uftc8inx 6277 26 18 18 CD cord-010092-uftc8inx 6277 27 units unit NNS cord-010092-uftc8inx 6277 28 in in IN cord-010092-uftc8inx 6277 29 350 350 CD cord-010092-uftc8inx 6277 30 mL ml NN cord-010092-uftc8inx 6277 31 quadruple quadruple JJ cord-010092-uftc8inx 6277 32 bags bag NNS cord-010092-uftc8inx 6277 33 ( ( -LRB- cord-010092-uftc8inx 6277 34 350Q 350Q NNP cord-010092-uftc8inx 6277 35 ) ) -RRB- cord-010092-uftc8inx 6277 36 , , , cord-010092-uftc8inx 6277 37 were be VBD cord-010092-uftc8inx 6277 38 processed process VBN cord-010092-uftc8inx 6277 39 in in IN cord-010092-uftc8inx 6277 40 accordance accordance NN cord-010092-uftc8inx 6277 41 with with IN cord-010092-uftc8inx 6277 42 HKRCBTS HKRCBTS NNP cord-010092-uftc8inx 6277 43 ' ' POS cord-010092-uftc8inx 6277 44 prevailing prevail VBG cord-010092-uftc8inx 6277 45 component component NN cord-010092-uftc8inx 6277 46 processing processing NN cord-010092-uftc8inx 6277 47 protocols protocol NNS cord-010092-uftc8inx 6277 48 except except IN cord-010092-uftc8inx 6277 49 using use VBG cord-010092-uftc8inx 6277 50 the the DT cord-010092-uftc8inx 6277 51 motor motor NN cord-010092-uftc8inx 6277 52 - - HYPH cord-010092-uftc8inx 6277 53 driven drive VBN cord-010092-uftc8inx 6277 54 mixer mixer NN cord-010092-uftc8inx 6277 55 in in IN cord-010092-uftc8inx 6277 56 lieu lieu NN cord-010092-uftc8inx 6277 57 of of IN cord-010092-uftc8inx 6277 58 manual manual JJ cord-010092-uftc8inx 6277 59 mixing mixing NN cord-010092-uftc8inx 6277 60 . . . cord-010092-uftc8inx 6278 1 WB WB NNP cord-010092-uftc8inx 6278 2 collections collection NNS cord-010092-uftc8inx 6278 3 were be VBD cord-010092-uftc8inx 6278 4 divided divide VBN cord-010092-uftc8inx 6278 5 into into IN cord-010092-uftc8inx 6278 6 2 2 CD cord-010092-uftc8inx 6278 7 groups group NNS cord-010092-uftc8inx 6278 8 , , , cord-010092-uftc8inx 6278 9 mixed mix VBN cord-010092-uftc8inx 6278 10 at at IN cord-010092-uftc8inx 6278 11 2 2 CD cord-010092-uftc8inx 6278 12 revolutions revolution NNS cord-010092-uftc8inx 6278 13 per per IN cord-010092-uftc8inx 6278 14 minute minute NN cord-010092-uftc8inx 6278 15 ( ( -LRB- cord-010092-uftc8inx 6278 16 rpm rpm NN cord-010092-uftc8inx 6278 17 ) ) -RRB- cord-010092-uftc8inx 6278 18 for for IN cord-010092-uftc8inx 6278 19 2 2 CD cord-010092-uftc8inx 6278 20 min min NN cord-010092-uftc8inx 6278 21 ( ( -LRB- cord-010092-uftc8inx 6278 22 n n NN cord-010092-uftc8inx 6278 23 = = SYM cord-010092-uftc8inx 6278 24 30 30 CD cord-010092-uftc8inx 6278 25 ) ) -RRB- cord-010092-uftc8inx 6278 26 and and CC cord-010092-uftc8inx 6278 27 30 30 CD cord-010092-uftc8inx 6278 28 min min NN cord-010092-uftc8inx 6278 29 ( ( -LRB- cord-010092-uftc8inx 6278 30 n n NN cord-010092-uftc8inx 6278 31 = = SYM cord-010092-uftc8inx 6278 32 28 28 CD cord-010092-uftc8inx 6278 33 ) ) -RRB- cord-010092-uftc8inx 6278 34 , , , cord-010092-uftc8inx 6278 35 then then RB cord-010092-uftc8inx 6278 36 processed process VBN cord-010092-uftc8inx 6278 37 into into IN cord-010092-uftc8inx 6278 38 RC RC NNP cord-010092-uftc8inx 6278 39 , , , cord-010092-uftc8inx 6278 40 PRP PRP NNP cord-010092-uftc8inx 6278 41 platelet platelet NN cord-010092-uftc8inx 6278 42 and and CC cord-010092-uftc8inx 6278 43 plasma plasma NN cord-010092-uftc8inx 6278 44 components component NNS cord-010092-uftc8inx 6278 45 . . . cord-010092-uftc8inx 6279 1 In in IN cord-010092-uftc8inx 6279 2 vitro vitro FW cord-010092-uftc8inx 6279 3 QC QC NNP cord-010092-uftc8inx 6279 4 assessments assessment NNS cord-010092-uftc8inx 6279 5 including include VBG cord-010092-uftc8inx 6279 6 haematocrit haematocrit NNP cord-010092-uftc8inx 6279 7 ( ( -LRB- cord-010092-uftc8inx 6279 8 Hct Hct NNP cord-010092-uftc8inx 6279 9 ) ) -RRB- cord-010092-uftc8inx 6279 10 , , , cord-010092-uftc8inx 6279 11 haemoglobulin haemoglobulin NNP cord-010092-uftc8inx 6279 12 ( ( -LRB- cord-010092-uftc8inx 6279 13 Hb Hb NNP cord-010092-uftc8inx 6279 14 ) ) -RRB- cord-010092-uftc8inx 6279 15 and and CC cord-010092-uftc8inx 6279 16 haemolysis haemolysis NN cord-010092-uftc8inx 6279 17 at at IN cord-010092-uftc8inx 6279 18 expiry expiry NN cord-010092-uftc8inx 6279 19 for for IN cord-010092-uftc8inx 6279 20 RC rc NN cord-010092-uftc8inx 6279 21 ; ; : cord-010092-uftc8inx 6279 22 absolute absolute JJ cord-010092-uftc8inx 6279 23 platelet platelet NN cord-010092-uftc8inx 6279 24 count count NN cord-010092-uftc8inx 6279 25 and and CC cord-010092-uftc8inx 6279 26 pH ph NN cord-010092-uftc8inx 6279 27 for for IN cord-010092-uftc8inx 6279 28 platelet platelet NN cord-010092-uftc8inx 6279 29 concentrates concentrate NNS cord-010092-uftc8inx 6279 30 ( ( -LRB- cord-010092-uftc8inx 6279 31 PLT PLT NNP cord-010092-uftc8inx 6279 32 ) ) -RRB- cord-010092-uftc8inx 6279 33 ; ; : cord-010092-uftc8inx 6279 34 volume volume NN cord-010092-uftc8inx 6279 35 and and CC cord-010092-uftc8inx 6279 36 residual residual JJ cord-010092-uftc8inx 6279 37 platelet platelet NN cord-010092-uftc8inx 6279 38 count count NN cord-010092-uftc8inx 6279 39 for for IN cord-010092-uftc8inx 6279 40 plasma plasma NN cord-010092-uftc8inx 6279 41 units unit NNS cord-010092-uftc8inx 6279 42 were be VBD cord-010092-uftc8inx 6279 43 evaluated evaluate VBN cord-010092-uftc8inx 6279 44 and and CC cord-010092-uftc8inx 6279 45 compared compare VBN cord-010092-uftc8inx 6279 46 . . . cord-010092-uftc8inx 6280 1 Results result NNS cord-010092-uftc8inx 6280 2 : : : cord-010092-uftc8inx 6281 1 All all DT cord-010092-uftc8inx 6281 2 components component NNS cord-010092-uftc8inx 6281 3 derived derive VBN cord-010092-uftc8inx 6281 4 from from IN cord-010092-uftc8inx 6281 5 both both DT cord-010092-uftc8inx 6281 6 450Q 450q CD cord-010092-uftc8inx 6281 7 and and CC cord-010092-uftc8inx 6281 8 350Q 350q CD cord-010092-uftc8inx 6281 9 processed process VBN cord-010092-uftc8inx 6281 10 with with IN cord-010092-uftc8inx 6281 11 the the DT cord-010092-uftc8inx 6281 12 blood blood NN cord-010092-uftc8inx 6281 13 mixer mixer NN cord-010092-uftc8inx 6281 14 fulfilled fulfil VBD cord-010092-uftc8inx 6281 15 the the DT cord-010092-uftc8inx 6281 16 QC QC NNP cord-010092-uftc8inx 6281 17 requirements requirement NNS cord-010092-uftc8inx 6281 18 stipulated stipulate VBN cord-010092-uftc8inx 6281 19 by by IN cord-010092-uftc8inx 6281 20 AABB AABB NNP cord-010092-uftc8inx 6281 21 Standards Standards NNPS cord-010092-uftc8inx 6281 22 and and CC cord-010092-uftc8inx 6281 23 Council Council NNP cord-010092-uftc8inx 6281 24 of of IN cord-010092-uftc8inx 6281 25 Europe Europe NNP cord-010092-uftc8inx 6281 26 ( ( -LRB- cord-010092-uftc8inx 6281 27 CoE CoE NNP cord-010092-uftc8inx 6281 28 ) ) -RRB- cord-010092-uftc8inx 6281 29 Guidelines Guidelines NNPS cord-010092-uftc8inx 6281 30 . . . cord-010092-uftc8inx 6282 1 There there EX cord-010092-uftc8inx 6282 2 were be VBD cord-010092-uftc8inx 6282 3 no no DT cord-010092-uftc8inx 6282 4 significant significant JJ cord-010092-uftc8inx 6282 5 differences difference NNS cord-010092-uftc8inx 6282 6 for for IN cord-010092-uftc8inx 6282 7 all all PDT cord-010092-uftc8inx 6282 8 the the DT cord-010092-uftc8inx 6282 9 QC QC NNP cord-010092-uftc8inx 6282 10 parameters parameter NNS cord-010092-uftc8inx 6282 11 in in IN cord-010092-uftc8inx 6282 12 RC rc NN cord-010092-uftc8inx 6282 13 and and CC cord-010092-uftc8inx 6282 14 plasma plasma NN cord-010092-uftc8inx 6282 15 components component NNS cord-010092-uftc8inx 6282 16 produced produce VBN cord-010092-uftc8inx 6282 17 when when WRB cord-010092-uftc8inx 6282 18 mixed mix VBN cord-010092-uftc8inx 6282 19 for for IN cord-010092-uftc8inx 6282 20 2 2 CD cord-010092-uftc8inx 6282 21 or or CC cord-010092-uftc8inx 6282 22 30 30 CD cord-010092-uftc8inx 6282 23 min min NN cord-010092-uftc8inx 6282 24 . . . cord-010092-uftc8inx 6283 1 Summary Summary NNP cord-010092-uftc8inx 6283 2 / / SYM cord-010092-uftc8inx 6283 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 6283 4 : : : cord-010092-uftc8inx 6284 1 The the DT cord-010092-uftc8inx 6284 2 overall overall JJ cord-010092-uftc8inx 6284 3 performance performance NN cord-010092-uftc8inx 6284 4 of of IN cord-010092-uftc8inx 6284 5 blood blood NN cord-010092-uftc8inx 6284 6 components component NNS cord-010092-uftc8inx 6284 7 processed process VBN cord-010092-uftc8inx 6284 8 with with IN cord-010092-uftc8inx 6284 9 the the DT cord-010092-uftc8inx 6284 10 motor motor NN cord-010092-uftc8inx 6284 11 - - HYPH cord-010092-uftc8inx 6284 12 driven drive VBN cord-010092-uftc8inx 6284 13 mixer mixer NN cord-010092-uftc8inx 6284 14 met meet VBD cord-010092-uftc8inx 6284 15 the the DT cord-010092-uftc8inx 6284 16 acceptance acceptance NN cord-010092-uftc8inx 6284 17 criteria criterion NNS cord-010092-uftc8inx 6284 18 at at IN cord-010092-uftc8inx 6284 19 the the DT cord-010092-uftc8inx 6284 20 HKRCBTS HKRCBTS NNP cord-010092-uftc8inx 6284 21 in in IN cord-010092-uftc8inx 6284 22 accordance accordance NN cord-010092-uftc8inx 6284 23 with with IN cord-010092-uftc8inx 6284 24 the the DT cord-010092-uftc8inx 6284 25 AABB AABB NNP cord-010092-uftc8inx 6284 26 and and CC cord-010092-uftc8inx 6284 27 CoE CoE NNP cord-010092-uftc8inx 6284 28 standards standards NNPS cord-010092-uftc8inx 6284 29 . . . cord-010092-uftc8inx 6285 1 Higher high JJR cord-010092-uftc8inx 6285 2 platelet platelet NN cord-010092-uftc8inx 6285 3 yield yield NN cord-010092-uftc8inx 6285 4 was be VBD cord-010092-uftc8inx 6285 5 observed observe VBN cord-010092-uftc8inx 6285 6 with with IN cord-010092-uftc8inx 6285 7 prolonged prolong VBN cord-010092-uftc8inx 6285 8 mixing mixing NN cord-010092-uftc8inx 6285 9 for for IN cord-010092-uftc8inx 6285 10 30 30 CD cord-010092-uftc8inx 6285 11 min min NN cord-010092-uftc8inx 6285 12 . . . cord-010092-uftc8inx 6286 1 However however RB cord-010092-uftc8inx 6286 2 , , , cord-010092-uftc8inx 6286 3 prolonged prolong VBN cord-010092-uftc8inx 6286 4 mixing mixing NN cord-010092-uftc8inx 6286 5 will will MD cord-010092-uftc8inx 6286 6 much much JJ cord-010092-uftc8inx 6286 7 delay delay VB cord-010092-uftc8inx 6286 8 routine routine JJ cord-010092-uftc8inx 6286 9 component component NN cord-010092-uftc8inx 6286 10 processing processing NN cord-010092-uftc8inx 6286 11 . . . cord-010092-uftc8inx 6287 1 Further further JJ cord-010092-uftc8inx 6287 2 evaluation evaluation NN cord-010092-uftc8inx 6287 3 on on IN cord-010092-uftc8inx 6287 4 intermediate intermediate JJ cord-010092-uftc8inx 6287 5 mixing mix VBG cord-010092-uftc8inx 6287 6 time time NN cord-010092-uftc8inx 6287 7 such such JJ cord-010092-uftc8inx 6287 8 as as IN cord-010092-uftc8inx 6287 9 3 3 CD cord-010092-uftc8inx 6287 10 , , , cord-010092-uftc8inx 6287 11 5 5 CD cord-010092-uftc8inx 6287 12 or or CC cord-010092-uftc8inx 6287 13 10 10 CD cord-010092-uftc8inx 6287 14 min min NN cord-010092-uftc8inx 6287 15 may may MD cord-010092-uftc8inx 6287 16 help help VB cord-010092-uftc8inx 6287 17 determine determine VB cord-010092-uftc8inx 6287 18 an an DT cord-010092-uftc8inx 6287 19 optimal optimal JJ cord-010092-uftc8inx 6287 20 mixing mix VBG cord-010092-uftc8inx 6287 21 duration duration NN cord-010092-uftc8inx 6287 22 to to TO cord-010092-uftc8inx 6287 23 maximise maximise VB cord-010092-uftc8inx 6287 24 platelet platelet NN cord-010092-uftc8inx 6287 25 yield yield NN cord-010092-uftc8inx 6287 26 without without IN cord-010092-uftc8inx 6287 27 compromising compromise VBG cord-010092-uftc8inx 6287 28 processing processing NN cord-010092-uftc8inx 6287 29 workflow workflow NN cord-010092-uftc8inx 6287 30 . . . cord-010092-uftc8inx 6288 1 To to TO cord-010092-uftc8inx 6288 2 conclude conclude VB cord-010092-uftc8inx 6288 3 , , , cord-010092-uftc8inx 6288 4 using use VBG cord-010092-uftc8inx 6288 5 the the DT cord-010092-uftc8inx 6288 6 modified modify VBN cord-010092-uftc8inx 6288 7 blood blood NN cord-010092-uftc8inx 6288 8 mixer mixer NN cord-010092-uftc8inx 6288 9 to to TO cord-010092-uftc8inx 6288 10 replace replace VB cord-010092-uftc8inx 6288 11 laborious laborious JJ cord-010092-uftc8inx 6288 12 manual manual JJ cord-010092-uftc8inx 6288 13 mixing mix VBG cord-010092-uftc8inx 6288 14 in in IN cord-010092-uftc8inx 6288 15 components component NNS cord-010092-uftc8inx 6288 16 preparation preparation NN cord-010092-uftc8inx 6288 17 is be VBZ cord-010092-uftc8inx 6288 18 promising promise VBG cord-010092-uftc8inx 6288 19 to to TO cord-010092-uftc8inx 6288 20 improve improve VB cord-010092-uftc8inx 6288 21 the the DT cord-010092-uftc8inx 6288 22 OH&S OH&S NNP cord-010092-uftc8inx 6288 23 for for IN cord-010092-uftc8inx 6288 24 blood blood NN cord-010092-uftc8inx 6288 25 component component NN cord-010092-uftc8inx 6288 26 preparation preparation NN cord-010092-uftc8inx 6288 27 operators operator NNS cord-010092-uftc8inx 6288 28 . . . cord-010092-uftc8inx 6289 1 Background background NN cord-010092-uftc8inx 6289 2 : : : cord-010092-uftc8inx 6290 1 Leukocyte Leukocyte NNP cord-010092-uftc8inx 6290 2 reduction reduction NN cord-010092-uftc8inx 6290 3 is be VBZ cord-010092-uftc8inx 6290 4 widely widely RB cord-010092-uftc8inx 6290 5 used use VBN cord-010092-uftc8inx 6290 6 to to TO cord-010092-uftc8inx 6290 7 reduce reduce VB cord-010092-uftc8inx 6290 8 the the DT cord-010092-uftc8inx 6290 9 risk risk NN cord-010092-uftc8inx 6290 10 of of IN cord-010092-uftc8inx 6290 11 non non JJ cord-010092-uftc8inx 6290 12 - - JJ cord-010092-uftc8inx 6290 13 hemolytic hemolytic JJ cord-010092-uftc8inx 6290 14 febrile febrile JJ cord-010092-uftc8inx 6290 15 transfusion transfusion NN cord-010092-uftc8inx 6290 16 reactions reaction NNS cord-010092-uftc8inx 6290 17 and and CC cord-010092-uftc8inx 6290 18 alloimmunization alloimmunization NN cord-010092-uftc8inx 6290 19 by by IN cord-010092-uftc8inx 6290 20 multiple multiple JJ cord-010092-uftc8inx 6290 21 blood blood NN cord-010092-uftc8inx 6290 22 transfusions transfusion NNS cord-010092-uftc8inx 6290 23 . . . cord-010092-uftc8inx 6291 1 Around around RB cord-010092-uftc8inx 6291 2 and and CC cord-010092-uftc8inx 6291 3 after after IN cord-010092-uftc8inx 6291 4 year year NN cord-010092-uftc8inx 6291 5 2000 2000 CD cord-010092-uftc8inx 6291 6 , , , cord-010092-uftc8inx 6291 7 universal universal JJ cord-010092-uftc8inx 6291 8 leukocyte leukocyte NN cord-010092-uftc8inx 6291 9 reduction reduction NN cord-010092-uftc8inx 6291 10 was be VBD cord-010092-uftc8inx 6291 11 adopted adopt VBN cord-010092-uftc8inx 6291 12 in in IN cord-010092-uftc8inx 6291 13 many many JJ cord-010092-uftc8inx 6291 14 developed develop VBN cord-010092-uftc8inx 6291 15 countries country NNS cord-010092-uftc8inx 6291 16 . . . cord-010092-uftc8inx 6292 1 There there EX cord-010092-uftc8inx 6292 2 are be VBP cord-010092-uftc8inx 6292 3 mainly mainly RB cord-010092-uftc8inx 6292 4 two two CD cord-010092-uftc8inx 6292 5 types type NNS cord-010092-uftc8inx 6292 6 of of IN cord-010092-uftc8inx 6292 7 filter filter NN cord-010092-uftc8inx 6292 8 , , , cord-010092-uftc8inx 6292 9 one one CD cord-010092-uftc8inx 6292 10 to to TO cord-010092-uftc8inx 6292 11 filter filter VB cord-010092-uftc8inx 6292 12 whole whole JJ cord-010092-uftc8inx 6292 13 blood blood NN cord-010092-uftc8inx 6292 14 and and CC cord-010092-uftc8inx 6292 15 the the DT cord-010092-uftc8inx 6292 16 other other JJ cord-010092-uftc8inx 6292 17 to to TO cord-010092-uftc8inx 6292 18 filter filter VB cord-010092-uftc8inx 6292 19 red red JJ cord-010092-uftc8inx 6292 20 cell cell NN cord-010092-uftc8inx 6292 21 concentrate concentrate NN cord-010092-uftc8inx 6292 22 ( ( -LRB- cord-010092-uftc8inx 6292 23 RCC RCC NNP cord-010092-uftc8inx 6292 24 ) ) -RRB- cord-010092-uftc8inx 6292 25 used use VBN cord-010092-uftc8inx 6292 26 during during IN cord-010092-uftc8inx 6292 27 pre pre JJ cord-010092-uftc8inx 6292 28 - - JJ cord-010092-uftc8inx 6292 29 storage storage JJ cord-010092-uftc8inx 6292 30 blood blood NN cord-010092-uftc8inx 6292 31 processing processing NN cord-010092-uftc8inx 6292 32 . . . cord-010092-uftc8inx 6293 1 Aims aim VBZ cord-010092-uftc8inx 6293 2 : : : cord-010092-uftc8inx 6294 1 In in IN cord-010092-uftc8inx 6294 2 this this DT cord-010092-uftc8inx 6294 3 study study NN cord-010092-uftc8inx 6294 4 , , , cord-010092-uftc8inx 6294 5 we -PRON- PRP cord-010092-uftc8inx 6294 6 conducted conduct VBD cord-010092-uftc8inx 6294 7 the the DT cord-010092-uftc8inx 6294 8 filtration filtration NN cord-010092-uftc8inx 6294 9 tests test NNS cord-010092-uftc8inx 6294 10 with with IN cord-010092-uftc8inx 6294 11 Sepacell Sepacell NNP cord-010092-uftc8inx 6294 12 TM TM NNP cord-010092-uftc8inx 6294 13 RS2 rs2 NN cord-010092-uftc8inx 6294 14 for for IN cord-010092-uftc8inx 6294 15 RCC RCC NNP cord-010092-uftc8inx 6294 16 in in IN cord-010092-uftc8inx 6294 17 comparison comparison NN cord-010092-uftc8inx 6294 18 with with IN cord-010092-uftc8inx 6294 19 Sepacell Sepacell NNP cord-010092-uftc8inx 6294 20 TM TM NNP cord-010092-uftc8inx 6294 21 R R NNP cord-010092-uftc8inx 6294 22 - - HYPH cord-010092-uftc8inx 6294 23 S11 S11 NNP cord-010092-uftc8inx 6294 24 and and CC cord-010092-uftc8inx 6294 25 Sepacell Sepacell NNP cord-010092-uftc8inx 6295 1 TM TM NNP cord-010092-uftc8inx 6295 2 Pure Pure NNP cord-010092-uftc8inx 6295 3 RC RC NNP cord-010092-uftc8inx 6295 4 widely widely RB cord-010092-uftc8inx 6295 5 used use VBN cord-010092-uftc8inx 6295 6 in in IN cord-010092-uftc8inx 6295 7 the the DT cord-010092-uftc8inx 6295 8 world world NN cord-010092-uftc8inx 6295 9 . . . cord-010092-uftc8inx 6296 1 Background background NN cord-010092-uftc8inx 6296 2 : : : cord-010092-uftc8inx 6297 1 The the DT cord-010092-uftc8inx 6297 2 Cardarelli Cardarelli NNP cord-010092-uftc8inx 6297 3 Hospital Hospital NNP cord-010092-uftc8inx 6297 4 Blood Blood NNP cord-010092-uftc8inx 6297 5 Bank Bank NNP cord-010092-uftc8inx 6297 6 processes process VBZ cord-010092-uftc8inx 6297 7 over over IN cord-010092-uftc8inx 6297 8 40,000 40,000 CD cord-010092-uftc8inx 6297 9 whole whole JJ cord-010092-uftc8inx 6297 10 blood blood NN cord-010092-uftc8inx 6297 11 units unit NNS cord-010092-uftc8inx 6297 12 yearly yearly RB cord-010092-uftc8inx 6297 13 . . . cord-010092-uftc8inx 6298 1 In in IN cord-010092-uftc8inx 6298 2 order order NN cord-010092-uftc8inx 6298 3 to to TO cord-010092-uftc8inx 6298 4 constantly constantly RB cord-010092-uftc8inx 6298 5 cope cope VB cord-010092-uftc8inx 6298 6 with with IN cord-010092-uftc8inx 6298 7 the the DT cord-010092-uftc8inx 6298 8 huge huge JJ cord-010092-uftc8inx 6298 9 demand demand NN cord-010092-uftc8inx 6298 10 for for IN cord-010092-uftc8inx 6298 11 platelets platelet NNS cord-010092-uftc8inx 6298 12 from from IN cord-010092-uftc8inx 6298 13 Oncohematology Oncohematology NNP cord-010092-uftc8inx 6298 14 and and CC cord-010092-uftc8inx 6298 15 Intensive Intensive NNP cord-010092-uftc8inx 6298 16 Care Care NNP cord-010092-uftc8inx 6298 17 departments department NNS cord-010092-uftc8inx 6298 18 , , , cord-010092-uftc8inx 6298 19 a a DT cord-010092-uftc8inx 6298 20 progressive progressive JJ cord-010092-uftc8inx 6298 21 review review NN cord-010092-uftc8inx 6298 22 of of IN cord-010092-uftc8inx 6298 23 the the DT cord-010092-uftc8inx 6298 24 processing processing NN cord-010092-uftc8inx 6298 25 protocols protocol NNS cord-010092-uftc8inx 6298 26 for for IN cord-010092-uftc8inx 6298 27 platelet platelet NN cord-010092-uftc8inx 6298 28 concentrates concentrate NNS cord-010092-uftc8inx 6298 29 ( ( -LRB- cord-010092-uftc8inx 6298 30 PC pc NN cord-010092-uftc8inx 6298 31 ) ) -RRB- cord-010092-uftc8inx 6298 32 from from IN cord-010092-uftc8inx 6298 33 buffy buffy NNP cord-010092-uftc8inx 6298 34 - - HYPH cord-010092-uftc8inx 6298 35 coat coat NN cord-010092-uftc8inx 6298 36 ( ( -LRB- cord-010092-uftc8inx 6298 37 BC BC NNP cord-010092-uftc8inx 6298 38 ) ) -RRB- cord-010092-uftc8inx 6298 39 pools pool NNS cord-010092-uftc8inx 6298 40 has have VBZ cord-010092-uftc8inx 6298 41 recently recently RB cord-010092-uftc8inx 6298 42 been be VBN cord-010092-uftc8inx 6298 43 implemented implement VBN cord-010092-uftc8inx 6298 44 to to TO cord-010092-uftc8inx 6298 45 reduce reduce VB cord-010092-uftc8inx 6298 46 the the DT cord-010092-uftc8inx 6298 47 number number NN cord-010092-uftc8inx 6298 48 of of IN cord-010092-uftc8inx 6298 49 units unit NNS cord-010092-uftc8inx 6298 50 assembled assemble VBN cord-010092-uftc8inx 6298 51 , , , cord-010092-uftc8inx 6298 52 from from IN cord-010092-uftc8inx 6298 53 5 5 CD cord-010092-uftc8inx 6298 54 ( ( -LRB- cord-010092-uftc8inx 6298 55 routine routine NN cord-010092-uftc8inx 6298 56 in in IN cord-010092-uftc8inx 6298 57 Italy Italy NNP cord-010092-uftc8inx 6298 58 ) ) -RRB- cord-010092-uftc8inx 6298 59 to to IN cord-010092-uftc8inx 6298 60 4 4 CD cord-010092-uftc8inx 6298 61 . . . cord-010092-uftc8inx 6299 1 The the DT cord-010092-uftc8inx 6299 2 4-BC 4-bc CD cord-010092-uftc8inx 6299 3 PC pc NN cord-010092-uftc8inx 6299 4 units unit NNS cord-010092-uftc8inx 6299 5 have have VBP cord-010092-uftc8inx 6299 6 slightly slightly RB cord-010092-uftc8inx 6299 7 lower low JJR cord-010092-uftc8inx 6299 8 volume volume NN cord-010092-uftc8inx 6299 9 and and CC cord-010092-uftc8inx 6299 10 plasma plasma NN cord-010092-uftc8inx 6299 11 content content NN cord-010092-uftc8inx 6299 12 , , , cord-010092-uftc8inx 6299 13 factors factor NNS cord-010092-uftc8inx 6299 14 that that WDT cord-010092-uftc8inx 6299 15 further further RB cord-010092-uftc8inx 6299 16 limit limit VBP cord-010092-uftc8inx 6299 17 the the DT cord-010092-uftc8inx 6299 18 transfusion transfusion NN cord-010092-uftc8inx 6299 19 risk risk NN cord-010092-uftc8inx 6299 20 . . . cord-010092-uftc8inx 6300 1 In in IN cord-010092-uftc8inx 6300 2 addition addition NN cord-010092-uftc8inx 6300 3 , , , cord-010092-uftc8inx 6300 4 the the DT cord-010092-uftc8inx 6300 5 4-BC 4-bc CD cord-010092-uftc8inx 6300 6 assembly assembly NN cord-010092-uftc8inx 6300 7 allows allow VBZ cord-010092-uftc8inx 6300 8 to to TO cord-010092-uftc8inx 6300 9 facilitate facilitate VB cord-010092-uftc8inx 6300 10 the the DT cord-010092-uftc8inx 6300 11 production production NN cord-010092-uftc8inx 6300 12 of of IN cord-010092-uftc8inx 6300 13 the the DT cord-010092-uftc8inx 6300 14 PC pc NN cord-010092-uftc8inx 6300 15 units unit NNS cord-010092-uftc8inx 6300 16 obtained obtain VBN cord-010092-uftc8inx 6300 17 from from IN cord-010092-uftc8inx 6300 18 the the DT cord-010092-uftc8inx 6300 19 same same JJ cord-010092-uftc8inx 6300 20 blood blood NN cord-010092-uftc8inx 6300 21 type type NN cord-010092-uftc8inx 6300 22 , , , cord-010092-uftc8inx 6300 23 in in IN cord-010092-uftc8inx 6300 24 order order NN cord-010092-uftc8inx 6300 25 to to TO cord-010092-uftc8inx 6300 26 minimize minimize VB cord-010092-uftc8inx 6300 27 both both CC cord-010092-uftc8inx 6300 28 the the DT cord-010092-uftc8inx 6300 29 adverse adverse JJ cord-010092-uftc8inx 6300 30 reactions reaction NNS cord-010092-uftc8inx 6300 31 related relate VBN cord-010092-uftc8inx 6300 32 to to IN cord-010092-uftc8inx 6300 33 the the DT cord-010092-uftc8inx 6300 34 ABO ABO NNP cord-010092-uftc8inx 6300 35 / / SYM cord-010092-uftc8inx 6300 36 Rh Rh NNP cord-010092-uftc8inx 6300 37 incompatibility incompatibility NN cord-010092-uftc8inx 6300 38 and and CC cord-010092-uftc8inx 6300 39 the the DT cord-010092-uftc8inx 6300 40 amount amount NN cord-010092-uftc8inx 6300 41 of of IN cord-010092-uftc8inx 6300 42 BCs BCs NNP cord-010092-uftc8inx 6300 43 not not RB cord-010092-uftc8inx 6300 44 used use VBD cord-010092-uftc8inx 6300 45 . . . cord-010092-uftc8inx 6301 1 Finally finally RB cord-010092-uftc8inx 6301 2 , , , cord-010092-uftc8inx 6301 3 the the DT cord-010092-uftc8inx 6301 4 described describe VBN cord-010092-uftc8inx 6301 5 innovation innovation NN cord-010092-uftc8inx 6301 6 also also RB cord-010092-uftc8inx 6301 7 impacts impact VBZ cord-010092-uftc8inx 6301 8 on on IN cord-010092-uftc8inx 6301 9 the the DT cord-010092-uftc8inx 6301 10 workload workload NN cord-010092-uftc8inx 6301 11 , , , cord-010092-uftc8inx 6301 12 with with IN cord-010092-uftc8inx 6301 13 reduction reduction NN cord-010092-uftc8inx 6301 14 of of IN cord-010092-uftc8inx 6301 15 assembly assembly NN cord-010092-uftc8inx 6301 16 , , , cord-010092-uftc8inx 6301 17 centrifugation centrifugation NN cord-010092-uftc8inx 6301 18 and and CC cord-010092-uftc8inx 6301 19 separation separation NN cord-010092-uftc8inx 6301 20 time time NN cord-010092-uftc8inx 6301 21 . . . cord-010092-uftc8inx 6302 1 Aims aim VBZ cord-010092-uftc8inx 6302 2 : : : cord-010092-uftc8inx 6303 1 The the DT cord-010092-uftc8inx 6303 2 aim aim NN cord-010092-uftc8inx 6303 3 of of IN cord-010092-uftc8inx 6303 4 this this DT cord-010092-uftc8inx 6303 5 work work NN cord-010092-uftc8inx 6303 6 is be VBZ cord-010092-uftc8inx 6303 7 to to TO cord-010092-uftc8inx 6303 8 define define VB cord-010092-uftc8inx 6303 9 an an DT cord-010092-uftc8inx 6303 10 optimized optimize VBN cord-010092-uftc8inx 6303 11 protocol protocol NN cord-010092-uftc8inx 6303 12 for for IN cord-010092-uftc8inx 6303 13 the the DT cord-010092-uftc8inx 6303 14 preparation preparation NN cord-010092-uftc8inx 6303 15 of of IN cord-010092-uftc8inx 6303 16 PC pc NN cord-010092-uftc8inx 6303 17 units unit NNS cord-010092-uftc8inx 6303 18 from from IN cord-010092-uftc8inx 6303 19 4-BC 4-bc CD cord-010092-uftc8inx 6303 20 pools pool NNS cord-010092-uftc8inx 6303 21 , , , cord-010092-uftc8inx 6303 22 so so IN cord-010092-uftc8inx 6303 23 that that IN cord-010092-uftc8inx 6303 24 the the DT cord-010092-uftc8inx 6303 25 platelet platelet NN cord-010092-uftc8inx 6303 26 yield yield NN cord-010092-uftc8inx 6303 27 is be VBZ cord-010092-uftc8inx 6303 28 always always RB cord-010092-uftc8inx 6303 29 higher high JJR cord-010092-uftc8inx 6303 30 than than IN cord-010092-uftc8inx 6303 31 the the DT cord-010092-uftc8inx 6303 32 minimum minimum JJ cord-010092-uftc8inx 6303 33 value value NN cord-010092-uftc8inx 6303 34 required require VBN cord-010092-uftc8inx 6303 35 by by IN cord-010092-uftc8inx 6303 36 current current JJ cord-010092-uftc8inx 6303 37 regulatory regulatory JJ cord-010092-uftc8inx 6303 38 ( ( -LRB- cord-010092-uftc8inx 6303 39 2.0 2.0 CD cord-010092-uftc8inx 6303 40 9 9 CD cord-010092-uftc8inx 6303 41 10 10 CD cord-010092-uftc8inx 6303 42 11 11 CD cord-010092-uftc8inx 6303 43 cells cell NNS cord-010092-uftc8inx 6303 44 / / SYM cord-010092-uftc8inx 6303 45 unit unit NN cord-010092-uftc8inx 6303 46 ) ) -RRB- cord-010092-uftc8inx 6303 47 . . . cord-010092-uftc8inx 6304 1 Background background NN cord-010092-uftc8inx 6304 2 : : : cord-010092-uftc8inx 6305 1 Blood blood NN cord-010092-uftc8inx 6305 2 is be VBZ cord-010092-uftc8inx 6305 3 a a DT cord-010092-uftc8inx 6305 4 basic basic JJ cord-010092-uftc8inx 6305 5 component component NN cord-010092-uftc8inx 6305 6 for for IN cord-010092-uftc8inx 6305 7 human human JJ cord-010092-uftc8inx 6305 8 life life NN cord-010092-uftc8inx 6305 9 and and CC cord-010092-uftc8inx 6305 10 hence hence RB cord-010092-uftc8inx 6305 11 blood blood NN cord-010092-uftc8inx 6305 12 transfusion transfusion NN cord-010092-uftc8inx 6305 13 is be VBZ cord-010092-uftc8inx 6305 14 an an DT cord-010092-uftc8inx 6305 15 integral integral JJ cord-010092-uftc8inx 6305 16 intervention intervention NN cord-010092-uftc8inx 6305 17 in in IN cord-010092-uftc8inx 6305 18 the the DT cord-010092-uftc8inx 6305 19 treatment treatment NN cord-010092-uftc8inx 6305 20 of of IN cord-010092-uftc8inx 6305 21 patients patient NNS cord-010092-uftc8inx 6305 22 . . . cord-010092-uftc8inx 6306 1 The the DT cord-010092-uftc8inx 6306 2 need need NN cord-010092-uftc8inx 6306 3 of of IN cord-010092-uftc8inx 6306 4 blood blood NN cord-010092-uftc8inx 6306 5 transfusion transfusion NN cord-010092-uftc8inx 6306 6 is be VBZ cord-010092-uftc8inx 6306 7 increasing increase VBG cord-010092-uftc8inx 6306 8 with with IN cord-010092-uftc8inx 6306 9 decreasing decrease VBG cord-010092-uftc8inx 6306 10 blood blood NN cord-010092-uftc8inx 6306 11 supply supply NN cord-010092-uftc8inx 6306 12 due due JJ cord-010092-uftc8inx 6306 13 to to IN cord-010092-uftc8inx 6306 14 limited limited JJ cord-010092-uftc8inx 6306 15 blood blood NN cord-010092-uftc8inx 6306 16 donations donation NNS cord-010092-uftc8inx 6306 17 . . . cord-010092-uftc8inx 6307 1 Conversely conversely RB cord-010092-uftc8inx 6307 2 wastage wastage NN cord-010092-uftc8inx 6307 3 of of IN cord-010092-uftc8inx 6307 4 blood blood NN cord-010092-uftc8inx 6307 5 products product NNS cord-010092-uftc8inx 6307 6 is be VBZ cord-010092-uftc8inx 6307 7 also also RB cord-010092-uftc8inx 6307 8 a a DT cord-010092-uftc8inx 6307 9 topic topic NN cord-010092-uftc8inx 6307 10 for for IN cord-010092-uftc8inx 6307 11 discussion discussion NN cord-010092-uftc8inx 6307 12 . . . cord-010092-uftc8inx 6308 1 To to TO cord-010092-uftc8inx 6308 2 ensure ensure VB cord-010092-uftc8inx 6308 3 the the DT cord-010092-uftc8inx 6308 4 availability availability NN cord-010092-uftc8inx 6308 5 of of IN cord-010092-uftc8inx 6308 6 blood blood NN cord-010092-uftc8inx 6308 7 products product NNS cord-010092-uftc8inx 6308 8 when when WRB cord-010092-uftc8inx 6308 9 they -PRON- PRP cord-010092-uftc8inx 6308 10 are be VBP cord-010092-uftc8inx 6308 11 needed need VBN cord-010092-uftc8inx 6308 12 , , , cord-010092-uftc8inx 6308 13 wastage wastage NN cord-010092-uftc8inx 6308 14 of of IN cord-010092-uftc8inx 6308 15 blood blood NN cord-010092-uftc8inx 6308 16 products product NNS cord-010092-uftc8inx 6308 17 should should MD cord-010092-uftc8inx 6308 18 be be VB cord-010092-uftc8inx 6308 19 controlled control VBN cord-010092-uftc8inx 6308 20 and and CC cord-010092-uftc8inx 6308 21 minimized minimize VBN cord-010092-uftc8inx 6308 22 . . . cord-010092-uftc8inx 6309 1 Aims aim VBZ cord-010092-uftc8inx 6309 2 : : : cord-010092-uftc8inx 6310 1 The the DT cord-010092-uftc8inx 6310 2 study study NN cord-010092-uftc8inx 6310 3 was be VBD cord-010092-uftc8inx 6310 4 designed design VBN cord-010092-uftc8inx 6310 5 to to TO cord-010092-uftc8inx 6310 6 investigate investigate VB cord-010092-uftc8inx 6310 7 the the DT cord-010092-uftc8inx 6310 8 quantity quantity NN cord-010092-uftc8inx 6310 9 and and CC cord-010092-uftc8inx 6310 10 reasons reason NNS cord-010092-uftc8inx 6310 11 of of IN cord-010092-uftc8inx 6310 12 wastage wastage NN cord-010092-uftc8inx 6310 13 of of IN cord-010092-uftc8inx 6310 14 blood blood NN cord-010092-uftc8inx 6310 15 products product NNS cord-010092-uftc8inx 6310 16 at at IN cord-010092-uftc8inx 6310 17 our -PRON- PRP$ cord-010092-uftc8inx 6310 18 hospital hospital NN cord-010092-uftc8inx 6310 19 . . . cord-010092-uftc8inx 6311 1 Methods method NNS cord-010092-uftc8inx 6311 2 : : : cord-010092-uftc8inx 6311 3 This this DT cord-010092-uftc8inx 6311 4 was be VBD cord-010092-uftc8inx 6311 5 an an DT cord-010092-uftc8inx 6311 6 observational observational JJ cord-010092-uftc8inx 6311 7 study study NN cord-010092-uftc8inx 6311 8 based base VBN cord-010092-uftc8inx 6311 9 on on IN cord-010092-uftc8inx 6311 10 the the DT cord-010092-uftc8inx 6311 11 statistical statistical JJ cord-010092-uftc8inx 6311 12 data datum NNS cord-010092-uftc8inx 6311 13 available available JJ cord-010092-uftc8inx 6311 14 from from IN cord-010092-uftc8inx 6311 15 blood blood NN cord-010092-uftc8inx 6311 16 bank bank NN cord-010092-uftc8inx 6311 17 department department NN cord-010092-uftc8inx 6311 18 of of IN cord-010092-uftc8inx 6311 19 NIBD NIBD NNP cord-010092-uftc8inx 6311 20 and and CC cord-010092-uftc8inx 6311 21 BMT BMT NNP cord-010092-uftc8inx 6311 22 , , , cord-010092-uftc8inx 6311 23 PECHS PECHS NNP cord-010092-uftc8inx 6311 24 campus campus NN cord-010092-uftc8inx 6311 25 , , , cord-010092-uftc8inx 6311 26 Karachi Karachi NNP cord-010092-uftc8inx 6311 27 , , , cord-010092-uftc8inx 6311 28 Pakistan Pakistan NNP cord-010092-uftc8inx 6311 29 . . . cord-010092-uftc8inx 6312 1 The the DT cord-010092-uftc8inx 6312 2 study study NN cord-010092-uftc8inx 6312 3 period period NN cord-010092-uftc8inx 6312 4 was be VBD cord-010092-uftc8inx 6312 5 from from IN cord-010092-uftc8inx 6312 6 February February NNP cord-010092-uftc8inx 6312 7 2018 2018 CD cord-010092-uftc8inx 6312 8 to to IN cord-010092-uftc8inx 6312 9 February February NNP cord-010092-uftc8inx 6312 10 2019 2019 CD cord-010092-uftc8inx 6312 11 . . . cord-010092-uftc8inx 6313 1 Study study NN cord-010092-uftc8inx 6313 2 was be VBD cord-010092-uftc8inx 6313 3 approved approve VBN cord-010092-uftc8inx 6313 4 from from IN cord-010092-uftc8inx 6313 5 institutional institutional JJ cord-010092-uftc8inx 6313 6 review review NNP cord-010092-uftc8inx 6313 7 board board NN cord-010092-uftc8inx 6313 8 . . . cord-010092-uftc8inx 6314 1 For for IN cord-010092-uftc8inx 6314 2 all all PDT cord-010092-uftc8inx 6314 3 the the DT cord-010092-uftc8inx 6314 4 blood blood NN cord-010092-uftc8inx 6314 5 products product NNS cord-010092-uftc8inx 6314 6 wastage wastage NN cord-010092-uftc8inx 6314 7 and and CC cord-010092-uftc8inx 6314 8 reasons reason NNS cord-010092-uftc8inx 6314 9 of of IN cord-010092-uftc8inx 6314 10 wastage wastage NN cord-010092-uftc8inx 6314 11 were be VBD cord-010092-uftc8inx 6314 12 evaluated evaluate VBN cord-010092-uftc8inx 6314 13 . . . cord-010092-uftc8inx 6315 1 Frequencies frequency NNS cord-010092-uftc8inx 6315 2 were be VBD cord-010092-uftc8inx 6315 3 calculated calculate VBN cord-010092-uftc8inx 6315 4 by by IN cord-010092-uftc8inx 6315 5 using use VBG cord-010092-uftc8inx 6315 6 SPSS SPSS NNP cord-010092-uftc8inx 6315 7 version version NN cord-010092-uftc8inx 6315 8 23.0 23.0 CD cord-010092-uftc8inx 6315 9 Results result NNS cord-010092-uftc8inx 6315 10 : : : cord-010092-uftc8inx 6315 11 A a DT cord-010092-uftc8inx 6315 12 total total NN cord-010092-uftc8inx 6315 13 of of IN cord-010092-uftc8inx 6315 14 2880 2880 CD cord-010092-uftc8inx 6315 15 blood blood NN cord-010092-uftc8inx 6315 16 products product NNS cord-010092-uftc8inx 6315 17 were be VBD cord-010092-uftc8inx 6315 18 available available JJ cord-010092-uftc8inx 6315 19 at at IN cord-010092-uftc8inx 6315 20 our -PRON- PRP$ cord-010092-uftc8inx 6315 21 institute institute NN cord-010092-uftc8inx 6315 22 including include VBG cord-010092-uftc8inx 6315 23 960 960 CD cord-010092-uftc8inx 6315 24 each each DT cord-010092-uftc8inx 6315 25 of of IN cord-010092-uftc8inx 6315 26 platelets platelet NNS cord-010092-uftc8inx 6315 27 , , , cord-010092-uftc8inx 6315 28 pack pack VBP cord-010092-uftc8inx 6315 29 red red JJ cord-010092-uftc8inx 6315 30 cells cell NNS cord-010092-uftc8inx 6315 31 and and CC cord-010092-uftc8inx 6315 32 fresh fresh JJ cord-010092-uftc8inx 6315 33 frozen frozen JJ cord-010092-uftc8inx 6315 34 plasma(FFP plasma(ffp CD cord-010092-uftc8inx 6315 35 ) ) -RRB- cord-010092-uftc8inx 6315 36 . . . cord-010092-uftc8inx 6316 1 The the DT cord-010092-uftc8inx 6316 2 overall overall JJ cord-010092-uftc8inx 6316 3 wastage wastage NN cord-010092-uftc8inx 6316 4 rate rate NN cord-010092-uftc8inx 6316 5 was be VBD cord-010092-uftc8inx 6316 6 3.5 3.5 CD cord-010092-uftc8inx 6316 7 % % NN cord-010092-uftc8inx 6316 8 . . . cord-010092-uftc8inx 6317 1 Pack pack VB cord-010092-uftc8inx 6317 2 red red JJ cord-010092-uftc8inx 6317 3 cells cell NNS cord-010092-uftc8inx 6317 4 and and CC cord-010092-uftc8inx 6317 5 platelets platelet NNS cord-010092-uftc8inx 6317 6 were be VBD cord-010092-uftc8inx 6317 7 fully fully RB cord-010092-uftc8inx 6317 8 consumed consume VBN cord-010092-uftc8inx 6317 9 yet yet CC cord-010092-uftc8inx 6317 10 shortage shortage NN cord-010092-uftc8inx 6317 11 of of IN cord-010092-uftc8inx 6317 12 supply supply NN cord-010092-uftc8inx 6317 13 was be VBD cord-010092-uftc8inx 6317 14 observed observe VBN cord-010092-uftc8inx 6317 15 . . . cord-010092-uftc8inx 6318 1 However however RB cord-010092-uftc8inx 6318 2 , , , cord-010092-uftc8inx 6318 3 highest high JJS cord-010092-uftc8inx 6318 4 wastage wastage NN cord-010092-uftc8inx 6318 5 was be VBD cord-010092-uftc8inx 6318 6 observed observe VBN cord-010092-uftc8inx 6318 7 in in IN cord-010092-uftc8inx 6318 8 FFP FFP NNP cord-010092-uftc8inx 6318 9 in in IN cord-010092-uftc8inx 6318 10 our -PRON- PRP$ cord-010092-uftc8inx 6318 11 blood blood NN cord-010092-uftc8inx 6318 12 bank bank NN cord-010092-uftc8inx 6318 13 i.e. i.e. FW cord-010092-uftc8inx 6318 14 102(10 102(10 CD cord-010092-uftc8inx 6318 15 % % NN cord-010092-uftc8inx 6318 16 ) ) -RRB- cord-010092-uftc8inx 6318 17 . . . cord-010092-uftc8inx 6319 1 Results result NNS cord-010092-uftc8inx 6319 2 of of IN cord-010092-uftc8inx 6319 3 investigating investigate VBG cord-010092-uftc8inx 6319 4 the the DT cord-010092-uftc8inx 6319 5 common common JJ cord-010092-uftc8inx 6319 6 causes cause NNS cord-010092-uftc8inx 6319 7 of of IN cord-010092-uftc8inx 6319 8 blood blood NN cord-010092-uftc8inx 6319 9 product product NN cord-010092-uftc8inx 6319 10 wastage wastage NN cord-010092-uftc8inx 6319 11 at at IN cord-010092-uftc8inx 6319 12 the the DT cord-010092-uftc8inx 6319 13 hospital hospital NN cord-010092-uftc8inx 6319 14 revealed reveal VBD cord-010092-uftc8inx 6319 15 that that IN cord-010092-uftc8inx 6319 16 it -PRON- PRP cord-010092-uftc8inx 6319 17 was be VBD cord-010092-uftc8inx 6319 18 highly highly RB cord-010092-uftc8inx 6319 19 associated associate VBN cord-010092-uftc8inx 6319 20 with with IN cord-010092-uftc8inx 6319 21 02 02 CD cord-010092-uftc8inx 6319 22 common common JJ cord-010092-uftc8inx 6319 23 causes cause NNS cord-010092-uftc8inx 6319 24 , , , cord-010092-uftc8inx 6319 25 including include VBG cord-010092-uftc8inx 6319 26 the the DT cord-010092-uftc8inx 6319 27 expiry expiry NN cord-010092-uftc8inx 6319 28 of of IN cord-010092-uftc8inx 6319 29 unused unused JJ cord-010092-uftc8inx 6319 30 products product NNS cord-010092-uftc8inx 6319 31 60(59 60(59 CD cord-010092-uftc8inx 6319 32 % % NN cord-010092-uftc8inx 6319 33 ) ) -RRB- cord-010092-uftc8inx 6319 34 followed follow VBN cord-010092-uftc8inx 6319 35 by by IN cord-010092-uftc8inx 6319 36 broken broken JJ cord-010092-uftc8inx 6319 37 bags bag NNS cord-010092-uftc8inx 6319 38 30(29 30(29 CD cord-010092-uftc8inx 6319 39 % % NN cord-010092-uftc8inx 6319 40 ) ) -RRB- cord-010092-uftc8inx 6319 41 . . . cord-010092-uftc8inx 6320 1 Summary Summary NNP cord-010092-uftc8inx 6320 2 / / SYM cord-010092-uftc8inx 6320 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 6320 4 : : : cord-010092-uftc8inx 6321 1 This this DT cord-010092-uftc8inx 6321 2 study study NN cord-010092-uftc8inx 6321 3 showed show VBD cord-010092-uftc8inx 6321 4 over over IN cord-010092-uftc8inx 6321 5 all all DT cord-010092-uftc8inx 6321 6 diminutive diminutive JJ cord-010092-uftc8inx 6321 7 wastage wastage NN cord-010092-uftc8inx 6321 8 rate rate NN cord-010092-uftc8inx 6321 9 . . . cord-010092-uftc8inx 6322 1 FFP ffp NN cord-010092-uftc8inx 6322 2 wastage wastage NN cord-010092-uftc8inx 6322 3 was be VBD cord-010092-uftc8inx 6322 4 highest high JJS cord-010092-uftc8inx 6322 5 among among IN cord-010092-uftc8inx 6322 6 all all PDT cord-010092-uftc8inx 6322 7 the the DT cord-010092-uftc8inx 6322 8 blood blood NN cord-010092-uftc8inx 6322 9 products product NNS cord-010092-uftc8inx 6322 10 . . . cord-010092-uftc8inx 6323 1 Wastage wastage NN cord-010092-uftc8inx 6323 2 of of IN cord-010092-uftc8inx 6323 3 blood blood NN cord-010092-uftc8inx 6323 4 products product NNS cord-010092-uftc8inx 6323 5 is be VBZ cord-010092-uftc8inx 6323 6 a a DT cord-010092-uftc8inx 6323 7 genuine genuine JJ cord-010092-uftc8inx 6323 8 issue issue NN cord-010092-uftc8inx 6323 9 in in IN cord-010092-uftc8inx 6323 10 a a DT cord-010092-uftc8inx 6323 11 hospital hospital NN cord-010092-uftc8inx 6323 12 setup setup NN cord-010092-uftc8inx 6323 13 , , , cord-010092-uftc8inx 6323 14 strategies strategy NNS cord-010092-uftc8inx 6323 15 and and CC cord-010092-uftc8inx 6323 16 plan plan NN cord-010092-uftc8inx 6323 17 of of IN cord-010092-uftc8inx 6323 18 action action NN cord-010092-uftc8inx 6323 19 should should MD cord-010092-uftc8inx 6323 20 be be VB cord-010092-uftc8inx 6323 21 discussed discuss VBN cord-010092-uftc8inx 6323 22 and and CC cord-010092-uftc8inx 6323 23 implemented implement VBN cord-010092-uftc8inx 6323 24 including include VBG cord-010092-uftc8inx 6323 25 enhanced enhanced JJ cord-010092-uftc8inx 6323 26 collaboration collaboration NN cord-010092-uftc8inx 6323 27 with with IN cord-010092-uftc8inx 6323 28 other other JJ cord-010092-uftc8inx 6323 29 centres centre NNS cord-010092-uftc8inx 6323 30 to to TO cord-010092-uftc8inx 6323 31 outsource outsource VB cord-010092-uftc8inx 6323 32 the the DT cord-010092-uftc8inx 6323 33 blood blood NN cord-010092-uftc8inx 6323 34 products product NNS cord-010092-uftc8inx 6323 35 or or CC cord-010092-uftc8inx 6323 36 even even RB cord-010092-uftc8inx 6323 37 donate donate VB cord-010092-uftc8inx 6323 38 at at IN cord-010092-uftc8inx 6323 39 times time NNS cord-010092-uftc8inx 6323 40 , , , cord-010092-uftc8inx 6323 41 education education NN cord-010092-uftc8inx 6323 42 and and CC cord-010092-uftc8inx 6323 43 training training NN cord-010092-uftc8inx 6323 44 of of IN cord-010092-uftc8inx 6323 45 staff staff NN cord-010092-uftc8inx 6323 46 for for IN cord-010092-uftc8inx 6323 47 better well JJR cord-010092-uftc8inx 6323 48 clinical clinical JJ cord-010092-uftc8inx 6323 49 use use NN cord-010092-uftc8inx 6323 50 of of IN cord-010092-uftc8inx 6323 51 blood blood NN cord-010092-uftc8inx 6323 52 products product NNS cord-010092-uftc8inx 6323 53 and and CC cord-010092-uftc8inx 6323 54 ensure ensure VB cord-010092-uftc8inx 6323 55 the the DT cord-010092-uftc8inx 6323 56 availability availability NN cord-010092-uftc8inx 6323 57 when when WRB cord-010092-uftc8inx 6323 58 and and CC cord-010092-uftc8inx 6323 59 where where WRB cord-010092-uftc8inx 6323 60 they -PRON- PRP cord-010092-uftc8inx 6323 61 are be VBP cord-010092-uftc8inx 6323 62 needed need VBN cord-010092-uftc8inx 6323 63 most most RBS cord-010092-uftc8inx 6323 64 . . . cord-010092-uftc8inx 6324 1 Background background NN cord-010092-uftc8inx 6324 2 : : : cord-010092-uftc8inx 6325 1 In in IN cord-010092-uftc8inx 6325 2 the the DT cord-010092-uftc8inx 6325 3 early early JJ cord-010092-uftc8inx 6325 4 2000s 2000 NNS cord-010092-uftc8inx 6325 5 , , , cord-010092-uftc8inx 6325 6 the the DT cord-010092-uftc8inx 6325 7 blood blood NN cord-010092-uftc8inx 6325 8 service service NN cord-010092-uftc8inx 6325 9 of of IN cord-010092-uftc8inx 6325 10 the the DT cord-010092-uftc8inx 6325 11 Republic Republic NNP cord-010092-uftc8inx 6325 12 of of IN cord-010092-uftc8inx 6325 13 Kazakhstan Kazakhstan NNP cord-010092-uftc8inx 6325 14 functioned function VBD cord-010092-uftc8inx 6325 15 along along IN cord-010092-uftc8inx 6325 16 the the DT cord-010092-uftc8inx 6325 17 lines line NNS cord-010092-uftc8inx 6325 18 of of IN cord-010092-uftc8inx 6325 19 the the DT cord-010092-uftc8inx 6325 20 Soviet soviet JJ cord-010092-uftc8inx 6325 21 period period NN cord-010092-uftc8inx 6325 22 : : : cord-010092-uftc8inx 6325 23 donation donation NN cord-010092-uftc8inx 6325 24 of of IN cord-010092-uftc8inx 6325 25 blood blood NN cord-010092-uftc8inx 6325 26 was be VBD cord-010092-uftc8inx 6325 27 approached approach VBN cord-010092-uftc8inx 6325 28 to to IN cord-010092-uftc8inx 6325 29 the the DT cord-010092-uftc8inx 6325 30 place place NN cord-010092-uftc8inx 6325 31 of of IN cord-010092-uftc8inx 6325 32 its -PRON- PRP$ cord-010092-uftc8inx 6325 33 use use NN cord-010092-uftc8inx 6325 34 ( ( -LRB- cord-010092-uftc8inx 6325 35 carried carry VBN cord-010092-uftc8inx 6325 36 out out RP cord-010092-uftc8inx 6325 37 at at IN cord-010092-uftc8inx 6325 38 hospitals hospital NNS cord-010092-uftc8inx 6325 39 ) ) -RRB- cord-010092-uftc8inx 6325 40 , , , cord-010092-uftc8inx 6325 41 screening screening NN cord-010092-uftc8inx 6325 42 of of IN cord-010092-uftc8inx 6325 43 donor donor NN cord-010092-uftc8inx 6325 44 blood blood NN cord-010092-uftc8inx 6325 45 was be VBD cord-010092-uftc8inx 6325 46 carried carry VBN cord-010092-uftc8inx 6325 47 out out RP cord-010092-uftc8inx 6325 48 at at IN cord-010092-uftc8inx 6325 49 one one CD cord-010092-uftc8inx 6325 50 stage stage NN cord-010092-uftc8inx 6325 51 ( ( -LRB- cord-010092-uftc8inx 6325 52 enzyme enzyme NN cord-010092-uftc8inx 6325 53 immunoassay immunoassay NN cord-010092-uftc8inx 6325 54 ) ) -RRB- cord-010092-uftc8inx 6325 55 on on IN cord-010092-uftc8inx 6325 56 analyzers analyzer NNS cord-010092-uftc8inx 6325 57 of of IN cord-010092-uftc8inx 6325 58 semi semi JJ cord-010092-uftc8inx 6325 59 - - JJ cord-010092-uftc8inx 6325 60 automatic automatic JJ cord-010092-uftc8inx 6325 61 type type NN cord-010092-uftc8inx 6325 62 , , , cord-010092-uftc8inx 6325 63 there there EX cord-010092-uftc8inx 6325 64 was be VBD cord-010092-uftc8inx 6325 65 no no DT cord-010092-uftc8inx 6325 66 mechanism mechanism NN cord-010092-uftc8inx 6325 67 calculating calculate VBG cord-010092-uftc8inx 6325 68 the the DT cord-010092-uftc8inx 6325 69 cost cost NN cord-010092-uftc8inx 6325 70 of of IN cord-010092-uftc8inx 6325 71 blood blood NN cord-010092-uftc8inx 6325 72 components component NNS cord-010092-uftc8inx 6325 73 , , , cord-010092-uftc8inx 6325 74 the the DT cord-010092-uftc8inx 6325 75 activity activity NN cord-010092-uftc8inx 6325 76 of of IN cord-010092-uftc8inx 6325 77 blood blood NN cord-010092-uftc8inx 6325 78 centers center NNS cord-010092-uftc8inx 6325 79 was be VBD cord-010092-uftc8inx 6325 80 funded fund VBN cord-010092-uftc8inx 6325 81 at at IN cord-010092-uftc8inx 6325 82 the the DT cord-010092-uftc8inx 6325 83 rate rate NN cord-010092-uftc8inx 6325 84 of of IN cord-010092-uftc8inx 6325 85 1 1 CD cord-010092-uftc8inx 6325 86 liter liter NN cord-010092-uftc8inx 6325 87 of of IN cord-010092-uftc8inx 6325 88 whole whole JJ cord-010092-uftc8inx 6325 89 blood blood NN cord-010092-uftc8inx 6325 90 . . . cord-010092-uftc8inx 6326 1 Donation donation NN cord-010092-uftc8inx 6326 2 was be VBD cord-010092-uftc8inx 6326 3 not not RB cord-010092-uftc8inx 6326 4 popular popular JJ cord-010092-uftc8inx 6326 5 in in IN cord-010092-uftc8inx 6326 6 society society NN cord-010092-uftc8inx 6326 7 , , , cord-010092-uftc8inx 6326 8 household household NN cord-010092-uftc8inx 6326 9 fears fear NNS cord-010092-uftc8inx 6326 10 of of IN cord-010092-uftc8inx 6326 11 infection infection NN cord-010092-uftc8inx 6326 12 were be VBD cord-010092-uftc8inx 6326 13 common common JJ cord-010092-uftc8inx 6326 14 when when WRB cord-010092-uftc8inx 6326 15 donated donate VBN cord-010092-uftc8inx 6326 16 . . . cord-010092-uftc8inx 6327 1 Aims aim VBZ cord-010092-uftc8inx 6327 2 : : : cord-010092-uftc8inx 6328 1 Research research NN cord-010092-uftc8inx 6328 2 objective objective NN cord-010092-uftc8inx 6328 3 is be VBZ cord-010092-uftc8inx 6328 4 to to TO cord-010092-uftc8inx 6328 5 study study VB cord-010092-uftc8inx 6328 6 the the DT cord-010092-uftc8inx 6328 7 main main JJ cord-010092-uftc8inx 6328 8 stages stage NNS cord-010092-uftc8inx 6328 9 of of IN cord-010092-uftc8inx 6328 10 reforming reform VBG cord-010092-uftc8inx 6328 11 of of IN cord-010092-uftc8inx 6328 12 blood blood NN cord-010092-uftc8inx 6328 13 services service NNS cord-010092-uftc8inx 6328 14 of of IN cord-010092-uftc8inx 6328 15 the the DT cord-010092-uftc8inx 6328 16 Republic Republic NNP cord-010092-uftc8inx 6328 17 of of IN cord-010092-uftc8inx 6328 18 Kazakhstan Kazakhstan NNP cord-010092-uftc8inx 6328 19 ( ( -LRB- cord-010092-uftc8inx 6328 20 RoK RoK NNP cord-010092-uftc8inx 6328 21 ) ) -RRB- cord-010092-uftc8inx 6328 22 . . . cord-010092-uftc8inx 6329 1 The the DT cord-010092-uftc8inx 6329 2 research research NN cord-010092-uftc8inx 6329 3 methods method NNS cord-010092-uftc8inx 6329 4 are be VBP cord-010092-uftc8inx 6329 5 based base VBN cord-010092-uftc8inx 6329 6 on on IN cord-010092-uftc8inx 6329 7 the the DT cord-010092-uftc8inx 6329 8 system system NN cord-010092-uftc8inx 6329 9 analysis analysis NN cord-010092-uftc8inx 6329 10 of of IN cord-010092-uftc8inx 6329 11 the the DT cord-010092-uftc8inx 6329 12 condition condition NN cord-010092-uftc8inx 6329 13 of of IN cord-010092-uftc8inx 6329 14 the the DT cord-010092-uftc8inx 6329 15 RoK RoK NNP cord-010092-uftc8inx 6329 16 's 's POS cord-010092-uftc8inx 6329 17 blood blood NN cord-010092-uftc8inx 6329 18 services service NNS cord-010092-uftc8inx 6329 19 based base VBN cord-010092-uftc8inx 6329 20 on on IN cord-010092-uftc8inx 6329 21 the the DT cord-010092-uftc8inx 6329 22 indicators indicator NNS cord-010092-uftc8inx 6329 23 of of IN cord-010092-uftc8inx 6329 24 production production NN cord-010092-uftc8inx 6329 25 activity activity NN cord-010092-uftc8inx 6329 26 for for IN cord-010092-uftc8inx 6329 27 the the DT cord-010092-uftc8inx 6329 28 period period NN cord-010092-uftc8inx 6329 29 of of IN cord-010092-uftc8inx 6329 30 2010 2010 CD cord-010092-uftc8inx 6329 31 - - SYM cord-010092-uftc8inx 6329 32 2017 2017 CD cord-010092-uftc8inx 6329 33 . . . cord-010092-uftc8inx 6330 1 Results result NNS cord-010092-uftc8inx 6330 2 : : : cord-010092-uftc8inx 6331 1 In in IN cord-010092-uftc8inx 6331 2 order order NN cord-010092-uftc8inx 6331 3 to to TO cord-010092-uftc8inx 6331 4 effectively effectively RB cord-010092-uftc8inx 6331 5 reform reform VB cord-010092-uftc8inx 6331 6 the the DT cord-010092-uftc8inx 6331 7 blood blood NN cord-010092-uftc8inx 6331 8 services service NNS cord-010092-uftc8inx 6331 9 , , , cord-010092-uftc8inx 6331 10 the the DT cord-010092-uftc8inx 6331 11 following following JJ cord-010092-uftc8inx 6331 12 steps step NNS cord-010092-uftc8inx 6331 13 were be VBD cord-010092-uftc8inx 6331 14 taken take VBN cord-010092-uftc8inx 6331 15 . . . cord-010092-uftc8inx 6332 1 The the DT cord-010092-uftc8inx 6332 2 blood blood NN cord-010092-uftc8inx 6332 3 supply supply NN cord-010092-uftc8inx 6332 4 was be VBD cord-010092-uftc8inx 6332 5 centralized centralize VBN cord-010092-uftc8inx 6332 6 and and CC cord-010092-uftc8inx 6332 7 optimized optimize VBN cord-010092-uftc8inx 6332 8 . . . cord-010092-uftc8inx 6333 1 Blood blood NN cord-010092-uftc8inx 6333 2 collection collection NN cord-010092-uftc8inx 6333 3 at at IN cord-010092-uftc8inx 6333 4 hospitals hospital NNS cord-010092-uftc8inx 6333 5 was be VBD cord-010092-uftc8inx 6333 6 terminated terminate VBN cord-010092-uftc8inx 6333 7 , , , cord-010092-uftc8inx 6333 8 more more JJR cord-010092-uftc8inx 6333 9 than than IN cord-010092-uftc8inx 6333 10 200 200 CD cord-010092-uftc8inx 6333 11 blood blood NN cord-010092-uftc8inx 6333 12 collection collection NN cord-010092-uftc8inx 6333 13 subjects subject NNS cord-010092-uftc8inx 6333 14 were be VBD cord-010092-uftc8inx 6333 15 closed close VBN cord-010092-uftc8inx 6333 16 . . . cord-010092-uftc8inx 6334 1 The the DT cord-010092-uftc8inx 6334 2 result result NN cord-010092-uftc8inx 6334 3 was be VBD cord-010092-uftc8inx 6334 4 a a DT cord-010092-uftc8inx 6334 5 more more RBR cord-010092-uftc8inx 6334 6 efficient efficient JJ cord-010092-uftc8inx 6334 7 use use NN cord-010092-uftc8inx 6334 8 of of IN cord-010092-uftc8inx 6334 9 technical technical JJ cord-010092-uftc8inx 6334 10 , , , cord-010092-uftc8inx 6334 11 human human JJ cord-010092-uftc8inx 6334 12 and and CC cord-010092-uftc8inx 6334 13 financial financial JJ cord-010092-uftc8inx 6334 14 resources resource NNS cord-010092-uftc8inx 6334 15 , , , cord-010092-uftc8inx 6334 16 as as RB cord-010092-uftc8inx 6334 17 well well RB cord-010092-uftc8inx 6334 18 as as IN cord-010092-uftc8inx 6334 19 ensuring ensure VBG cord-010092-uftc8inx 6334 20 the the DT cord-010092-uftc8inx 6334 21 high high JJ cord-010092-uftc8inx 6334 22 quality quality NN cord-010092-uftc8inx 6334 23 of of IN cord-010092-uftc8inx 6334 24 the the DT cord-010092-uftc8inx 6334 25 blood blood NN cord-010092-uftc8inx 6334 26 components component NNS cord-010092-uftc8inx 6334 27 produced produce VBN cord-010092-uftc8inx 6334 28 . . . cord-010092-uftc8inx 6335 1 Today today NN cord-010092-uftc8inx 6335 2 , , , cord-010092-uftc8inx 6335 3 there there EX cord-010092-uftc8inx 6335 4 are be VBP cord-010092-uftc8inx 6335 5 18 18 CD cord-010092-uftc8inx 6335 6 blood blood NN cord-010092-uftc8inx 6335 7 centers center NNS cord-010092-uftc8inx 6335 8 in in IN cord-010092-uftc8inx 6335 9 the the DT cord-010092-uftc8inx 6335 10 republicone republicone NN cord-010092-uftc8inx 6335 11 for for IN cord-010092-uftc8inx 6335 12 each each DT cord-010092-uftc8inx 6335 13 of of IN cord-010092-uftc8inx 6335 14 the the DT cord-010092-uftc8inx 6335 15 18 18 CD cord-010092-uftc8inx 6335 16 administrative administrative JJ cord-010092-uftc8inx 6335 17 territorial territorial JJ cord-010092-uftc8inx 6335 18 units unit NNS cord-010092-uftc8inx 6335 19 of of IN cord-010092-uftc8inx 6335 20 the the DT cord-010092-uftc8inx 6335 21 republic republic NN cord-010092-uftc8inx 6335 22 . . . cord-010092-uftc8inx 6336 1 The the DT cord-010092-uftc8inx 6336 2 screening screening NN cord-010092-uftc8inx 6336 3 of of IN cord-010092-uftc8inx 6336 4 donor donor NN cord-010092-uftc8inx 6336 5 blood blood NN cord-010092-uftc8inx 6336 6 for for IN cord-010092-uftc8inx 6336 7 transfusion transfusion NN cord-010092-uftc8inx 6336 8 infection infection NN cord-010092-uftc8inx 6336 9 markers marker NNS cord-010092-uftc8inx 6336 10 has have VBZ cord-010092-uftc8inx 6336 11 been be VBN cord-010092-uftc8inx 6336 12 transferred transfer VBN cord-010092-uftc8inx 6336 13 into into IN cord-010092-uftc8inx 6336 14 a a DT cord-010092-uftc8inx 6336 15 two two CD cord-010092-uftc8inx 6336 16 - - HYPH cord-010092-uftc8inx 6336 17 step step NN cord-010092-uftc8inx 6336 18 principleimmunological principleimmunological JJ cord-010092-uftc8inx 6336 19 analysis analysis NN cord-010092-uftc8inx 6336 20 and and CC cord-010092-uftc8inx 6336 21 NAT NAT NNP cord-010092-uftc8inx 6336 22 testing testing NN cord-010092-uftc8inx 6336 23 . . . cord-010092-uftc8inx 6337 1 A a DT cord-010092-uftc8inx 6337 2 fully fully RB cord-010092-uftc8inx 6337 3 automated automate VBN cord-010092-uftc8inx 6337 4 analytical analytical JJ cord-010092-uftc8inx 6337 5 equipment equipment NN cord-010092-uftc8inx 6337 6 of of IN cord-010092-uftc8inx 6337 7 a a DT cord-010092-uftc8inx 6337 8 closed closed JJ cord-010092-uftc8inx 6337 9 type type NN cord-010092-uftc8inx 6337 10 is be VBZ cord-010092-uftc8inx 6337 11 used use VBN cord-010092-uftc8inx 6337 12 for for IN cord-010092-uftc8inx 6337 13 screening screening NN cord-010092-uftc8inx 6337 14 , , , cord-010092-uftc8inx 6337 15 unified unify VBN cord-010092-uftc8inx 6337 16 for for IN cord-010092-uftc8inx 6337 17 all all DT cord-010092-uftc8inx 6337 18 blood blood NN cord-010092-uftc8inx 6337 19 centers center NNS cord-010092-uftc8inx 6337 20 of of IN cord-010092-uftc8inx 6337 21 the the DT cord-010092-uftc8inx 6337 22 republic republic NN cord-010092-uftc8inx 6337 23 . . . cord-010092-uftc8inx 6338 1 Unification unification NN cord-010092-uftc8inx 6338 2 of of IN cord-010092-uftc8inx 6338 3 the the DT cord-010092-uftc8inx 6338 4 equipment equipment NN cord-010092-uftc8inx 6338 5 choice choice NN cord-010092-uftc8inx 6338 6 allowed allow VBN cord-010092-uftc8inx 6338 7 to to TO cord-010092-uftc8inx 6338 8 provide provide VB cord-010092-uftc8inx 6338 9 centralized centralized JJ cord-010092-uftc8inx 6338 10 service service NN cord-010092-uftc8inx 6338 11 maintenance maintenance NN cord-010092-uftc8inx 6338 12 of of IN cord-010092-uftc8inx 6338 13 complex complex JJ cord-010092-uftc8inx 6338 14 equipment equipment NN cord-010092-uftc8inx 6338 15 and and CC cord-010092-uftc8inx 6338 16 its -PRON- PRP$ cord-010092-uftc8inx 6338 17 uninterrupted uninterrupted JJ cord-010092-uftc8inx 6338 18 operation operation NN cord-010092-uftc8inx 6338 19 . . . cord-010092-uftc8inx 6339 1 Since since IN cord-010092-uftc8inx 6339 2 2012 2012 CD cord-010092-uftc8inx 6339 3 , , , cord-010092-uftc8inx 6339 4 the the DT cord-010092-uftc8inx 6339 5 national national NNP cord-010092-uftc8inx 6339 6 reference reference NN cord-010092-uftc8inx 6339 7 laboratory laboratory NN cord-010092-uftc8inx 6339 8 has have VBZ cord-010092-uftc8inx 6339 9 been be VBN cord-010092-uftc8inx 6339 10 operating operate VBG cord-010092-uftc8inx 6339 11 in in IN cord-010092-uftc8inx 6339 12 the the DT cord-010092-uftc8inx 6339 13 blood blood NN cord-010092-uftc8inx 6339 14 service service NN cord-010092-uftc8inx 6339 15 , , , cord-010092-uftc8inx 6339 16 which which WDT cord-010092-uftc8inx 6339 17 conducts conduct VBZ cord-010092-uftc8inx 6339 18 an an DT cord-010092-uftc8inx 6339 19 external external JJ cord-010092-uftc8inx 6339 20 assessment assessment NN cord-010092-uftc8inx 6339 21 of of IN cord-010092-uftc8inx 6339 22 the the DT cord-010092-uftc8inx 6339 23 quality quality NN cord-010092-uftc8inx 6339 24 of of IN cord-010092-uftc8inx 6339 25 laboratory laboratory NN cord-010092-uftc8inx 6339 26 research research NN cord-010092-uftc8inx 6339 27 in in IN cord-010092-uftc8inx 6339 28 blood blood NN cord-010092-uftc8inx 6339 29 centers center NNS cord-010092-uftc8inx 6339 30 , , , cord-010092-uftc8inx 6339 31 as as RB cord-010092-uftc8inx 6339 32 well well RB cord-010092-uftc8inx 6339 33 as as IN cord-010092-uftc8inx 6339 34 research research NN cord-010092-uftc8inx 6339 35 in in IN cord-010092-uftc8inx 6339 36 controversial controversial JJ cord-010092-uftc8inx 6339 37 and and CC cord-010092-uftc8inx 6339 38 complex complex JJ cord-010092-uftc8inx 6339 39 cases case NNS cord-010092-uftc8inx 6339 40 . . . cord-010092-uftc8inx 6340 1 Introduced introduce VBN cord-010092-uftc8inx 6340 2 pathogen pathogen NN cord-010092-uftc8inx 6340 3 inactivation inactivation NN cord-010092-uftc8inx 6340 4 of of IN cord-010092-uftc8inx 6340 5 platelet platelet NN cord-010092-uftc8inx 6340 6 concentrates concentrate VBZ cord-010092-uftc8inx 6340 7 in in IN cord-010092-uftc8inx 6340 8 100 100 CD cord-010092-uftc8inx 6340 9 % % NN cord-010092-uftc8inx 6340 10 of of IN cord-010092-uftc8inx 6340 11 cases case NNS cord-010092-uftc8inx 6340 12 of of IN cord-010092-uftc8inx 6340 13 platelets platelet NNS cord-010092-uftc8inx 6340 14 . . . cord-010092-uftc8inx 6341 1 Erythrocytes erythrocyte NNS cord-010092-uftc8inx 6341 2 are be VBP cord-010092-uftc8inx 6341 3 used use VBN cord-010092-uftc8inx 6341 4 only only RB cord-010092-uftc8inx 6341 5 in in IN cord-010092-uftc8inx 6341 6 the the DT cord-010092-uftc8inx 6341 7 weighing weighing NN cord-010092-uftc8inx 6341 8 solution solution NN cord-010092-uftc8inx 6341 9 and and CC cord-010092-uftc8inx 6341 10 only only RB cord-010092-uftc8inx 6341 11 after after IN cord-010092-uftc8inx 6341 12 leukoreduction leukoreduction NN cord-010092-uftc8inx 6341 13 . . . cord-010092-uftc8inx 6342 1 The the DT cord-010092-uftc8inx 6342 2 use use NN cord-010092-uftc8inx 6342 3 of of IN cord-010092-uftc8inx 6342 4 resource resource NN cord-010092-uftc8inx 6342 5 - - HYPH cord-010092-uftc8inx 6342 6 saving save VBG cord-010092-uftc8inx 6342 7 blood blood NN cord-010092-uftc8inx 6342 8 harvesting harvesting NN cord-010092-uftc8inx 6342 9 technologies technology NNS cord-010092-uftc8inx 6342 10 , , , cord-010092-uftc8inx 6342 11 as as RB cord-010092-uftc8inx 6342 12 well well RB cord-010092-uftc8inx 6342 13 as as IN cord-010092-uftc8inx 6342 14 methods method NNS cord-010092-uftc8inx 6342 15 to to TO cord-010092-uftc8inx 6342 16 further further RB cord-010092-uftc8inx 6342 17 enhance enhance VB cord-010092-uftc8inx 6342 18 the the DT cord-010092-uftc8inx 6342 19 infectious infectious JJ cord-010092-uftc8inx 6342 20 and and CC cord-010092-uftc8inx 6342 21 immunological immunological JJ cord-010092-uftc8inx 6342 22 safety safety NN cord-010092-uftc8inx 6342 23 of of IN cord-010092-uftc8inx 6342 24 components component NNS cord-010092-uftc8inx 6342 25 , , , cord-010092-uftc8inx 6342 26 are be VBP cord-010092-uftc8inx 6342 27 expanding expand VBG cord-010092-uftc8inx 6342 28 annually annually RB cord-010092-uftc8inx 6342 29 . . . cord-010092-uftc8inx 6343 1 The the DT cord-010092-uftc8inx 6343 2 foundations foundation NNS cord-010092-uftc8inx 6343 3 for for IN cord-010092-uftc8inx 6343 4 the the DT cord-010092-uftc8inx 6343 5 development development NN cord-010092-uftc8inx 6343 6 of of IN cord-010092-uftc8inx 6343 7 applied applied JJ cord-010092-uftc8inx 6343 8 scientific scientific JJ cord-010092-uftc8inx 6343 9 research research NN cord-010092-uftc8inx 6343 10 in in IN cord-010092-uftc8inx 6343 11 the the DT cord-010092-uftc8inx 6343 12 field field NN cord-010092-uftc8inx 6343 13 of of IN cord-010092-uftc8inx 6343 14 transfusion transfusion NN cord-010092-uftc8inx 6343 15 medicine medicine NN cord-010092-uftc8inx 6343 16 were be VBD cord-010092-uftc8inx 6343 17 laid lay VBN cord-010092-uftc8inx 6343 18 , , , cord-010092-uftc8inx 6343 19 and and CC cord-010092-uftc8inx 6343 20 an an DT cord-010092-uftc8inx 6343 21 own own JJ cord-010092-uftc8inx 6343 22 school school NN cord-010092-uftc8inx 6343 23 of of IN cord-010092-uftc8inx 6343 24 transfusiologists transfusiologist NNS cord-010092-uftc8inx 6343 25 was be VBD cord-010092-uftc8inx 6343 26 created create VBN cord-010092-uftc8inx 6343 27 . . . cord-010092-uftc8inx 6344 1 As as IN cord-010092-uftc8inx 6344 2 a a DT cord-010092-uftc8inx 6344 3 result result NN cord-010092-uftc8inx 6344 4 of of IN cord-010092-uftc8inx 6344 5 reforming reform VBG cord-010092-uftc8inx 6344 6 the the DT cord-010092-uftc8inx 6344 7 blood blood NN cord-010092-uftc8inx 6344 8 services service NNS cord-010092-uftc8inx 6344 9 , , , cord-010092-uftc8inx 6344 10 the the DT cord-010092-uftc8inx 6344 11 mechanisms mechanism NNS cord-010092-uftc8inx 6344 12 of of IN cord-010092-uftc8inx 6344 13 reimbursement reimbursement NN cord-010092-uftc8inx 6344 14 of of IN cord-010092-uftc8inx 6344 15 blood blood NN cord-010092-uftc8inx 6344 16 services service NNS cord-010092-uftc8inx 6344 17 costs cost NNS cord-010092-uftc8inx 6344 18 from from IN cord-010092-uftc8inx 6344 19 the the DT cord-010092-uftc8inx 6344 20 budget budget NN cord-010092-uftc8inx 6344 21 of of IN cord-010092-uftc8inx 6344 22 the the DT cord-010092-uftc8inx 6344 23 republic republic NN cord-010092-uftc8inx 6344 24 have have VBP cord-010092-uftc8inx 6344 25 been be VBN cord-010092-uftc8inx 6344 26 changed change VBN cord-010092-uftc8inx 6344 27 , , , cord-010092-uftc8inx 6344 28 uniform uniform JJ cord-010092-uftc8inx 6344 29 tariffs tariff NNS cord-010092-uftc8inx 6344 30 have have VBP cord-010092-uftc8inx 6344 31 been be VBN cord-010092-uftc8inx 6344 32 defined define VBN cord-010092-uftc8inx 6344 33 by by IN cord-010092-uftc8inx 6344 34 type type NN cord-010092-uftc8inx 6344 35 of of IN cord-010092-uftc8inx 6344 36 blood blood NN cord-010092-uftc8inx 6344 37 components component NNS cord-010092-uftc8inx 6344 38 for for IN cord-010092-uftc8inx 6344 39 all all DT cord-010092-uftc8inx 6344 40 blood blood NN cord-010092-uftc8inx 6344 41 components component NNS cord-010092-uftc8inx 6344 42 suppliers supplier NNS cord-010092-uftc8inx 6344 43 in in IN cord-010092-uftc8inx 6344 44 the the DT cord-010092-uftc8inx 6344 45 country country NN cord-010092-uftc8inx 6344 46 . . . cord-010092-uftc8inx 6345 1 Summary Summary NNP cord-010092-uftc8inx 6345 2 / / SYM cord-010092-uftc8inx 6345 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 6345 4 : : : cord-010092-uftc8inx 6346 1 The the DT cord-010092-uftc8inx 6346 2 transformations transformation NNS cord-010092-uftc8inx 6346 3 made make VBD cord-010092-uftc8inx 6346 4 it -PRON- PRP cord-010092-uftc8inx 6346 5 possible possible JJ cord-010092-uftc8inx 6346 6 to to TO cord-010092-uftc8inx 6346 7 create create VB cord-010092-uftc8inx 6346 8 a a DT cord-010092-uftc8inx 6346 9 blood blood NN cord-010092-uftc8inx 6346 10 service service NN cord-010092-uftc8inx 6346 11 in in IN cord-010092-uftc8inx 6346 12 Kazakhstan Kazakhstan NNP cord-010092-uftc8inx 6346 13 that that WDT cord-010092-uftc8inx 6346 14 corresponds correspond VBZ cord-010092-uftc8inx 6346 15 to to IN cord-010092-uftc8inx 6346 16 the the DT cord-010092-uftc8inx 6346 17 best good JJS cord-010092-uftc8inx 6346 18 international international JJ cord-010092-uftc8inx 6346 19 practice practice NN cord-010092-uftc8inx 6346 20 and and CC cord-010092-uftc8inx 6346 21 ensures ensure VBZ cord-010092-uftc8inx 6346 22 the the DT cord-010092-uftc8inx 6346 23 quality quality NN cord-010092-uftc8inx 6346 24 , , , cord-010092-uftc8inx 6346 25 efficacy efficacy NN cord-010092-uftc8inx 6346 26 and and CC cord-010092-uftc8inx 6346 27 safety safety NN cord-010092-uftc8inx 6346 28 of of IN cord-010092-uftc8inx 6346 29 transfusion transfusion NN cord-010092-uftc8inx 6346 30 therapy therapy NN cord-010092-uftc8inx 6346 31 . . . cord-010092-uftc8inx 6347 1 Further further JJ cord-010092-uftc8inx 6347 2 development development NN cord-010092-uftc8inx 6347 3 of of IN cord-010092-uftc8inx 6347 4 the the DT cord-010092-uftc8inx 6347 5 blood blood NN cord-010092-uftc8inx 6347 6 service service NN cord-010092-uftc8inx 6347 7 is be VBZ cord-010092-uftc8inx 6347 8 aimed aim VBN cord-010092-uftc8inx 6347 9 at at IN cord-010092-uftc8inx 6347 10 deepening deepen VBG cord-010092-uftc8inx 6347 11 reforms reform NNS cord-010092-uftc8inx 6347 12 , , , cord-010092-uftc8inx 6347 13 studying study VBG cord-010092-uftc8inx 6347 14 and and CC cord-010092-uftc8inx 6347 15 developing develop VBG cord-010092-uftc8inx 6347 16 cellular cellular JJ cord-010092-uftc8inx 6347 17 technologies technology NNS cord-010092-uftc8inx 6347 18 , , , cord-010092-uftc8inx 6347 19 new new JJ cord-010092-uftc8inx 6347 20 properties property NNS cord-010092-uftc8inx 6347 21 of of IN cord-010092-uftc8inx 6347 22 plasma plasma NN cord-010092-uftc8inx 6347 23 blood blood NN cord-010092-uftc8inx 6347 24 components component NNS cord-010092-uftc8inx 6347 25 , , , cord-010092-uftc8inx 6347 26 and and CC cord-010092-uftc8inx 6347 27 improving improve VBG cord-010092-uftc8inx 6347 28 the the DT cord-010092-uftc8inx 6347 29 clinical clinical JJ cord-010092-uftc8inx 6347 30 practice practice NN cord-010092-uftc8inx 6347 31 of of IN cord-010092-uftc8inx 6347 32 using use VBG cord-010092-uftc8inx 6347 33 donor donor NN cord-010092-uftc8inx 6347 34 blood blood NN cord-010092-uftc8inx 6347 35 components component NNS cord-010092-uftc8inx 6347 36 . . . cord-010092-uftc8inx 6348 1 Background background NN cord-010092-uftc8inx 6348 2 : : : cord-010092-uftc8inx 6349 1 Reconstituted reconstitute VBN cord-010092-uftc8inx 6349 2 platelet platelet NN cord-010092-uftc8inx 6349 3 concentrate concentrate NN cord-010092-uftc8inx 6349 4 ( ( -LRB- cord-010092-uftc8inx 6349 5 RPC RPC NNP cord-010092-uftc8inx 6349 6 ) ) -RRB- cord-010092-uftc8inx 6349 7 is be VBZ cord-010092-uftc8inx 6349 8 a a DT cord-010092-uftc8inx 6349 9 component component NN cord-010092-uftc8inx 6349 10 that that WDT cord-010092-uftc8inx 6349 11 contains contain VBZ cord-010092-uftc8inx 6349 12 platelets platelet NNS cord-010092-uftc8inx 6349 13 ( ( -LRB- cord-010092-uftc8inx 6349 14 thrombocytes thrombocytes NNP cord-010092-uftc8inx 6349 15 ) ) -RRB- cord-010092-uftc8inx 6349 16 resuspended resuspend VBD cord-010092-uftc8inx 6349 17 in in IN cord-010092-uftc8inx 6349 18 plasma plasma NN cord-010092-uftc8inx 6349 19 that that WDT cord-010092-uftc8inx 6349 20 is be VBZ cord-010092-uftc8inx 6349 21 blood blood NN cord-010092-uftc8inx 6349 22 group group NN cord-010092-uftc8inx 6349 23 compatible compatible JJ cord-010092-uftc8inx 6349 24 with with IN cord-010092-uftc8inx 6349 25 the the DT cord-010092-uftc8inx 6349 26 recipient recipient NN cord-010092-uftc8inx 6349 27 . . . cord-010092-uftc8inx 6350 1 It -PRON- PRP cord-010092-uftc8inx 6350 2 is be VBZ cord-010092-uftc8inx 6350 3 used use VBN cord-010092-uftc8inx 6350 4 when when WRB cord-010092-uftc8inx 6350 5 transfusion transfusion NN cord-010092-uftc8inx 6350 6 of of IN cord-010092-uftc8inx 6350 7 platelet platelet NN cord-010092-uftc8inx 6350 8 concentrate concentrate NN cord-010092-uftc8inx 6350 9 is be VBZ cord-010092-uftc8inx 6350 10 necessary necessary JJ cord-010092-uftc8inx 6350 11 but but CC cord-010092-uftc8inx 6350 12 the the DT cord-010092-uftc8inx 6350 13 fresh fresh JJ cord-010092-uftc8inx 6350 14 platelet platelet NN cord-010092-uftc8inx 6350 15 concentrates concentrate VBZ cord-010092-uftc8inx 6350 16 of of IN cord-010092-uftc8inx 6350 17 the the DT cord-010092-uftc8inx 6350 18 specific specific JJ cord-010092-uftc8inx 6350 19 blood blood NN cord-010092-uftc8inx 6350 20 group group NN cord-010092-uftc8inx 6350 21 are be VBP cord-010092-uftc8inx 6350 22 not not RB cord-010092-uftc8inx 6350 23 available available JJ cord-010092-uftc8inx 6350 24 . . . cord-010092-uftc8inx 6351 1 Group group NN cord-010092-uftc8inx 6351 2 0 0 CD cord-010092-uftc8inx 6351 3 Rh-(negative Rh-(negative NNP cord-010092-uftc8inx 6351 4 ) ) -RRB- cord-010092-uftc8inx 6352 1 platelets platelet NNS cord-010092-uftc8inx 6352 2 resuspended resuspend VBD cord-010092-uftc8inx 6352 3 in in IN cord-010092-uftc8inx 6352 4 the the DT cord-010092-uftc8inx 6352 5 AB AB NNP cord-010092-uftc8inx 6352 6 group group NN cord-010092-uftc8inx 6352 7 plasma plasma NN cord-010092-uftc8inx 6352 8 are be VBP cord-010092-uftc8inx 6352 9 of of IN cord-010092-uftc8inx 6352 10 universal universal JJ cord-010092-uftc8inx 6352 11 use use NN cord-010092-uftc8inx 6352 12 as as IN cord-010092-uftc8inx 6352 13 such such JJ cord-010092-uftc8inx 6352 14 components component NNS cord-010092-uftc8inx 6352 15 can can MD cord-010092-uftc8inx 6352 16 be be VB cord-010092-uftc8inx 6352 17 used use VBN cord-010092-uftc8inx 6352 18 for for IN cord-010092-uftc8inx 6352 19 all all DT cord-010092-uftc8inx 6352 20 recipients recipient NNS cord-010092-uftc8inx 6352 21 independently independently RB cord-010092-uftc8inx 6352 22 of of IN cord-010092-uftc8inx 6352 23 their -PRON- PRP$ cord-010092-uftc8inx 6352 24 blood blood NN cord-010092-uftc8inx 6352 25 group group NN cord-010092-uftc8inx 6352 26 . . . cord-010092-uftc8inx 6353 1 In in IN cord-010092-uftc8inx 6353 2 the the DT cord-010092-uftc8inx 6353 3 area area NN cord-010092-uftc8inx 6353 4 of of IN cord-010092-uftc8inx 6353 5 activity activity NN cord-010092-uftc8inx 6353 6 of of IN cord-010092-uftc8inx 6353 7 Regional Regional NNP cord-010092-uftc8inx 6353 8 Blood Blood NNP cord-010092-uftc8inx 6353 9 Center Center NNP cord-010092-uftc8inx 6353 10 in in IN cord-010092-uftc8inx 6353 11 Poznan Poznan NNP cord-010092-uftc8inx 6353 12 RPC RPC NNP cord-010092-uftc8inx 6353 13 is be VBZ cord-010092-uftc8inx 6353 14 used use VBN cord-010092-uftc8inx 6353 15 most most RBS cord-010092-uftc8inx 6353 16 often often RB cord-010092-uftc8inx 6353 17 for for IN cord-010092-uftc8inx 6353 18 patients patient NNS cord-010092-uftc8inx 6353 19 after after IN cord-010092-uftc8inx 6353 20 stem stem NN cord-010092-uftc8inx 6353 21 cell cell NN cord-010092-uftc8inx 6353 22 transplant transplant NN cord-010092-uftc8inx 6353 23 incompatible incompatible JJ cord-010092-uftc8inx 6353 24 with with IN cord-010092-uftc8inx 6353 25 their -PRON- PRP$ cord-010092-uftc8inx 6353 26 blood blood NN cord-010092-uftc8inx 6353 27 group group NN cord-010092-uftc8inx 6353 28 . . . cord-010092-uftc8inx 6354 1 Aims aim VBZ cord-010092-uftc8inx 6354 2 : : : cord-010092-uftc8inx 6355 1 The the DT cord-010092-uftc8inx 6355 2 aim aim NN cord-010092-uftc8inx 6355 3 of of IN cord-010092-uftc8inx 6355 4 the the DT cord-010092-uftc8inx 6355 5 analysis analysis NN cord-010092-uftc8inx 6355 6 is be VBZ cord-010092-uftc8inx 6355 7 to to TO cord-010092-uftc8inx 6355 8 evaluate evaluate VB cord-010092-uftc8inx 6355 9 the the DT cord-010092-uftc8inx 6355 10 loss loss NN cord-010092-uftc8inx 6355 11 in in IN cord-010092-uftc8inx 6355 12 the the DT cord-010092-uftc8inx 6355 13 number number NN cord-010092-uftc8inx 6355 14 of of IN cord-010092-uftc8inx 6355 15 platelets platelet NNS cord-010092-uftc8inx 6355 16 in in IN cord-010092-uftc8inx 6355 17 the the DT cord-010092-uftc8inx 6355 18 reconstituted reconstitute VBN cord-010092-uftc8inx 6355 19 platelet platelet NN cord-010092-uftc8inx 6355 20 concentrates concentrate VBZ cord-010092-uftc8inx 6355 21 in in IN cord-010092-uftc8inx 6355 22 order order NN cord-010092-uftc8inx 6355 23 to to TO cord-010092-uftc8inx 6355 24 determine determine VB cord-010092-uftc8inx 6355 25 their -PRON- PRP$ cord-010092-uftc8inx 6355 26 quality quality NN cord-010092-uftc8inx 6355 27 and and CC cord-010092-uftc8inx 6355 28 usage usage NN cord-010092-uftc8inx 6355 29 . . . cord-010092-uftc8inx 6356 1 Methods method NNS cord-010092-uftc8inx 6356 2 : : : cord-010092-uftc8inx 6357 1 We -PRON- PRP cord-010092-uftc8inx 6357 2 used use VBD cord-010092-uftc8inx 6357 3 for for IN cord-010092-uftc8inx 6357 4 the the DT cord-010092-uftc8inx 6357 5 analysis analysis NN cord-010092-uftc8inx 6357 6 30 30 CD cord-010092-uftc8inx 6357 7 units unit NNS cord-010092-uftc8inx 6357 8 of of IN cord-010092-uftc8inx 6357 9 pooled pool VBN cord-010092-uftc8inx 6357 10 platelet platelet NN cord-010092-uftc8inx 6357 11 concentrate concentrate NN cord-010092-uftc8inx 6357 12 derived derive VBN cord-010092-uftc8inx 6357 13 from from IN cord-010092-uftc8inx 6357 14 buffy buffy NNP cord-010092-uftc8inx 6357 15 coats coat NNS cord-010092-uftc8inx 6357 16 and and CC cord-010092-uftc8inx 6357 17 30 30 CD cord-010092-uftc8inx 6357 18 units unit NNS cord-010092-uftc8inx 6357 19 of of IN cord-010092-uftc8inx 6357 20 pooled pool VBN cord-010092-uftc8inx 6357 21 platelet platelet NN cord-010092-uftc8inx 6357 22 concentrate concentrate NN cord-010092-uftc8inx 6357 23 derived derive VBN cord-010092-uftc8inx 6357 24 from from IN cord-010092-uftc8inx 6357 25 the the DT cord-010092-uftc8inx 6357 26 apheresis apheresis NN cord-010092-uftc8inx 6357 27 . . . cord-010092-uftc8inx 6358 1 For for IN cord-010092-uftc8inx 6358 2 the the DT cord-010092-uftc8inx 6358 3 reconstitution reconstitution NN cord-010092-uftc8inx 6358 4 group group NN cord-010092-uftc8inx 6358 5 AB AB NNP cord-010092-uftc8inx 6358 6 plasma plasma NN cord-010092-uftc8inx 6358 7 was be VBD cord-010092-uftc8inx 6358 8 used use VBN cord-010092-uftc8inx 6358 9 . . . cord-010092-uftc8inx 6359 1 We -PRON- PRP cord-010092-uftc8inx 6359 2 investigated investigate VBD cord-010092-uftc8inx 6359 3 the the DT cord-010092-uftc8inx 6359 4 number number NN cord-010092-uftc8inx 6359 5 of of IN cord-010092-uftc8inx 6359 6 platelets platelet NNS cord-010092-uftc8inx 6359 7 prior prior RB cord-010092-uftc8inx 6359 8 to to IN cord-010092-uftc8inx 6359 9 and and CC cord-010092-uftc8inx 6359 10 after after IN cord-010092-uftc8inx 6359 11 the the DT cord-010092-uftc8inx 6359 12 reconstitution reconstitution NN cord-010092-uftc8inx 6359 13 . . . cord-010092-uftc8inx 6360 1 Following follow VBG cord-010092-uftc8inx 6360 2 measures measure NNS cord-010092-uftc8inx 6360 3 were be VBD cord-010092-uftc8inx 6360 4 calculated calculate VBN cord-010092-uftc8inx 6360 5 : : : cord-010092-uftc8inx 6360 6 number number NN cord-010092-uftc8inx 6360 7 of of IN cord-010092-uftc8inx 6360 8 platelets platelet NNS cord-010092-uftc8inx 6360 9 in in IN cord-010092-uftc8inx 6360 10 pooled pool VBN cord-010092-uftc8inx 6360 11 platelet platelet NN cord-010092-uftc8inx 6360 12 concentrates concentrate VBZ cord-010092-uftc8inx 6360 13 derived derive VBN cord-010092-uftc8inx 6360 14 from from IN cord-010092-uftc8inx 6360 15 buffy buffy NNP cord-010092-uftc8inx 6360 16 coats coat NNS cord-010092-uftc8inx 6360 17 , , , cord-010092-uftc8inx 6360 18 number number NN cord-010092-uftc8inx 6360 19 of of IN cord-010092-uftc8inx 6360 20 platelets platelet NNS cord-010092-uftc8inx 6360 21 in in IN cord-010092-uftc8inx 6360 22 pooled pool VBN cord-010092-uftc8inx 6360 23 platelet platelet NN cord-010092-uftc8inx 6360 24 concentrates concentrate VBZ cord-010092-uftc8inx 6360 25 derived derive VBN cord-010092-uftc8inx 6360 26 from from IN cord-010092-uftc8inx 6360 27 apheresis apheresis NN cord-010092-uftc8inx 6360 28 ; ; : cord-010092-uftc8inx 6360 29 average average JJ cord-010092-uftc8inx 6360 30 values value NNS cord-010092-uftc8inx 6360 31 and and CC cord-010092-uftc8inx 6360 32 the the DT cord-010092-uftc8inx 6360 33 standard standard JJ cord-010092-uftc8inx 6360 34 deviation deviation NN cord-010092-uftc8inx 6360 35 as as RB cord-010092-uftc8inx 6360 36 well well RB cord-010092-uftc8inx 6360 37 as as IN cord-010092-uftc8inx 6360 38 the the DT cord-010092-uftc8inx 6360 39 loss loss NN cord-010092-uftc8inx 6360 40 in in IN cord-010092-uftc8inx 6360 41 number number NN cord-010092-uftc8inx 6360 42 of of IN cord-010092-uftc8inx 6360 43 platelets platelet NNS cord-010092-uftc8inx 6360 44 due due IN cord-010092-uftc8inx 6360 45 to to IN cord-010092-uftc8inx 6360 46 the the DT cord-010092-uftc8inx 6360 47 reconstitution reconstitution NN cord-010092-uftc8inx 6360 48 . . . cord-010092-uftc8inx 6361 1 The the DT cord-010092-uftc8inx 6361 2 number number NN cord-010092-uftc8inx 6361 3 of of IN cord-010092-uftc8inx 6361 4 platelets platelet NNS cord-010092-uftc8inx 6361 5 was be VBD cord-010092-uftc8inx 6361 6 calculated calculate VBN cord-010092-uftc8inx 6361 7 with with IN cord-010092-uftc8inx 6361 8 impedance impedance NN cord-010092-uftc8inx 6361 9 method method NN cord-010092-uftc8inx 6361 10 using use VBG cord-010092-uftc8inx 6361 11 Horiba Horiba NNP cord-010092-uftc8inx 6361 12 Pentra Pentra NNP cord-010092-uftc8inx 6361 13 XL XL NNP cord-010092-uftc8inx 6361 14 80 80 CD cord-010092-uftc8inx 6361 15 analyser analyser NN cord-010092-uftc8inx 6361 16 . . . cord-010092-uftc8inx 6362 1 1 1 LS cord-010092-uftc8inx 6362 2 . . . cord-010092-uftc8inx 6363 1 Pooled pool VBN cord-010092-uftc8inx 6363 2 platelet platelet NN cord-010092-uftc8inx 6363 3 concentrates concentrate VBZ cord-010092-uftc8inx 6363 4 derived derive VBN cord-010092-uftc8inx 6363 5 from from IN cord-010092-uftc8inx 6363 6 buffy buffy NNP cord-010092-uftc8inx 6363 7 coats coat VBZ cord-010092-uftc8inx 6363 8 the the DT cord-010092-uftc8inx 6363 9 number number NN cord-010092-uftc8inx 6363 10 of of IN cord-010092-uftc8inx 6363 11 platelets platelet NNS cord-010092-uftc8inx 6363 12 before before IN cord-010092-uftc8inx 6363 13 the the DT cord-010092-uftc8inx 6363 14 reconstitution reconstitution NN cord-010092-uftc8inx 6363 15 : : : cord-010092-uftc8inx 6363 16 4.12 4.12 CD cord-010092-uftc8inx 6363 17 9 9 CD cord-010092-uftc8inx 6363 18 10 10 CD cord-010092-uftc8inx 6363 19 11 11 CD cord-010092-uftc8inx 6363 20 /unit /unit . cord-010092-uftc8inx 6363 21 AE AE NNP cord-010092-uftc8inx 6363 22 0.50 0.50 CD cord-010092-uftc8inx 6363 23 the the DT cord-010092-uftc8inx 6363 24 number number NN cord-010092-uftc8inx 6363 25 of of IN cord-010092-uftc8inx 6363 26 platelets platelet NNS cord-010092-uftc8inx 6363 27 after after IN cord-010092-uftc8inx 6363 28 the the DT cord-010092-uftc8inx 6363 29 reconstitution reconstitution NN cord-010092-uftc8inx 6363 30 : : : cord-010092-uftc8inx 6363 31 3.40 3.40 CD cord-010092-uftc8inx 6363 32 9 9 CD cord-010092-uftc8inx 6363 33 10 10 CD cord-010092-uftc8inx 6363 34 11 11 CD cord-010092-uftc8inx 6363 35 /unit /unit . cord-010092-uftc8inx 6363 36 AE AE NNP cord-010092-uftc8inx 6363 37 0.50 0.50 CD cord-010092-uftc8inx 6363 38 the the DT cord-010092-uftc8inx 6363 39 loss loss NN cord-010092-uftc8inx 6363 40 in in IN cord-010092-uftc8inx 6363 41 the the DT cord-010092-uftc8inx 6363 42 number number NN cord-010092-uftc8inx 6363 43 of of IN cord-010092-uftc8inx 6363 44 platelets platelet NNS cord-010092-uftc8inx 6363 45 : : : cord-010092-uftc8inx 6363 46 17.5 17.5 CD cord-010092-uftc8inx 6363 47 % % NN cord-010092-uftc8inx 6363 48 2 2 CD cord-010092-uftc8inx 6363 49 . . . cord-010092-uftc8inx 6364 1 Platelet platelet NN cord-010092-uftc8inx 6364 2 concentrates concentrate VBZ cord-010092-uftc8inx 6364 3 derived derive VBN cord-010092-uftc8inx 6364 4 from from IN cord-010092-uftc8inx 6364 5 apheresis apheresis NN cord-010092-uftc8inx 6364 6 the the DT cord-010092-uftc8inx 6364 7 number number NN cord-010092-uftc8inx 6364 8 of of IN cord-010092-uftc8inx 6364 9 platelets platelet NNS cord-010092-uftc8inx 6364 10 before before IN cord-010092-uftc8inx 6364 11 the the DT cord-010092-uftc8inx 6364 12 reconstitution reconstitution NN cord-010092-uftc8inx 6364 13 : : : cord-010092-uftc8inx 6364 14 3.68 3.68 CD cord-010092-uftc8inx 6364 15 9 9 CD cord-010092-uftc8inx 6364 16 10 10 CD cord-010092-uftc8inx 6364 17 11 11 CD cord-010092-uftc8inx 6364 18 /unit /unit . cord-010092-uftc8inx 6364 19 AE AE NNP cord-010092-uftc8inx 6364 20 0.55 0.55 CD cord-010092-uftc8inx 6364 21 the the DT cord-010092-uftc8inx 6364 22 number number NN cord-010092-uftc8inx 6364 23 of of IN cord-010092-uftc8inx 6364 24 platelets platelet NNS cord-010092-uftc8inx 6364 25 after after IN cord-010092-uftc8inx 6364 26 the the DT cord-010092-uftc8inx 6364 27 reconstitution reconstitution NN cord-010092-uftc8inx 6364 28 : : : cord-010092-uftc8inx 6364 29 2.91 2.91 CD cord-010092-uftc8inx 6364 30 9 9 CD cord-010092-uftc8inx 6364 31 10 10 CD cord-010092-uftc8inx 6364 32 11 11 CD cord-010092-uftc8inx 6364 33 /unit /unit . cord-010092-uftc8inx 6364 34 AE AE NNP cord-010092-uftc8inx 6364 35 0.49 0.49 CD cord-010092-uftc8inx 6365 1 the the DT cord-010092-uftc8inx 6365 2 loss loss NN cord-010092-uftc8inx 6365 3 in in IN cord-010092-uftc8inx 6365 4 the the DT cord-010092-uftc8inx 6365 5 number number NN cord-010092-uftc8inx 6365 6 of of IN cord-010092-uftc8inx 6365 7 platelets platelet NNS cord-010092-uftc8inx 6365 8 : : : cord-010092-uftc8inx 6365 9 20.7 20.7 CD cord-010092-uftc8inx 6365 10 % % NN cord-010092-uftc8inx 6365 11 Summary Summary NNP cord-010092-uftc8inx 6365 12 / / SYM cord-010092-uftc8inx 6365 13 Conclusions Conclusions NNPS cord-010092-uftc8inx 6365 14 : : : cord-010092-uftc8inx 6365 15 1 1 CD cord-010092-uftc8inx 6365 16 . . . cord-010092-uftc8inx 6366 1 Reconstitution reconstitution NN cord-010092-uftc8inx 6366 2 results result NNS cord-010092-uftc8inx 6366 3 in in IN cord-010092-uftc8inx 6366 4 the the DT cord-010092-uftc8inx 6366 5 loss loss NN cord-010092-uftc8inx 6366 6 of of IN cord-010092-uftc8inx 6366 7 17.5 17.5 CD cord-010092-uftc8inx 6366 8 % % NN cord-010092-uftc8inx 6366 9 of of IN cord-010092-uftc8inx 6366 10 platelets platelet NNS cord-010092-uftc8inx 6366 11 in in IN cord-010092-uftc8inx 6366 12 comparison comparison NN cord-010092-uftc8inx 6366 13 to to IN cord-010092-uftc8inx 6366 14 the the DT cord-010092-uftc8inx 6366 15 initial initial JJ cord-010092-uftc8inx 6366 16 value value NN cord-010092-uftc8inx 6366 17 of of IN cord-010092-uftc8inx 6366 18 pooled pool VBN cord-010092-uftc8inx 6366 19 platelet platelet NN cord-010092-uftc8inx 6366 20 concentrate concentrate NN cord-010092-uftc8inx 6366 21 derived derive VBN cord-010092-uftc8inx 6366 22 from from IN cord-010092-uftc8inx 6366 23 buffy buffy NNP cord-010092-uftc8inx 6366 24 coats coat NNS cord-010092-uftc8inx 6366 25 . . . cord-010092-uftc8inx 6367 1 2 2 LS cord-010092-uftc8inx 6367 2 . . . cord-010092-uftc8inx 6368 1 The the DT cord-010092-uftc8inx 6368 2 average average JJ cord-010092-uftc8inx 6368 3 number number NN cord-010092-uftc8inx 6368 4 of of IN cord-010092-uftc8inx 6368 5 platelets platelet NNS cord-010092-uftc8inx 6368 6 after after IN cord-010092-uftc8inx 6368 7 the the DT cord-010092-uftc8inx 6368 8 reconstitution reconstitution NN cord-010092-uftc8inx 6368 9 is be VBZ cord-010092-uftc8inx 6368 10 3.4 3.4 CD cord-010092-uftc8inx 6368 11 9 9 CD cord-010092-uftc8inx 6368 12 10 10 CD cord-010092-uftc8inx 6368 13 11 11 CD cord-010092-uftc8inx 6368 14 /unit /unit , cord-010092-uftc8inx 6368 15 , , , cord-010092-uftc8inx 6368 16 which which WDT cord-010092-uftc8inx 6368 17 fulfils fulfil VBZ cord-010092-uftc8inx 6368 18 the the DT cord-010092-uftc8inx 6368 19 quality quality NN cord-010092-uftc8inx 6368 20 requirements requirement NNS cord-010092-uftc8inx 6368 21 . . . cord-010092-uftc8inx 6369 1 3 3 LS cord-010092-uftc8inx 6369 2 . . . cord-010092-uftc8inx 6370 1 Reconstitution reconstitution NN cord-010092-uftc8inx 6370 2 results result NNS cord-010092-uftc8inx 6370 3 in in IN cord-010092-uftc8inx 6370 4 the the DT cord-010092-uftc8inx 6370 5 loss loss NN cord-010092-uftc8inx 6370 6 of of IN cord-010092-uftc8inx 6370 7 20.7 20.7 CD cord-010092-uftc8inx 6370 8 % % NN cord-010092-uftc8inx 6370 9 of of IN cord-010092-uftc8inx 6370 10 platelets platelet NNS cord-010092-uftc8inx 6370 11 in in IN cord-010092-uftc8inx 6370 12 comparison comparison NN cord-010092-uftc8inx 6370 13 to to IN cord-010092-uftc8inx 6370 14 the the DT cord-010092-uftc8inx 6370 15 initial initial JJ cord-010092-uftc8inx 6370 16 value value NN cord-010092-uftc8inx 6370 17 of of IN cord-010092-uftc8inx 6370 18 pooled pool VBN cord-010092-uftc8inx 6370 19 platelet platelet NN cord-010092-uftc8inx 6370 20 concentrate concentrate NN cord-010092-uftc8inx 6370 21 derived derive VBN cord-010092-uftc8inx 6370 22 from from IN cord-010092-uftc8inx 6370 23 apheresis apheresis NN cord-010092-uftc8inx 6370 24 . . . cord-010092-uftc8inx 6371 1 4 4 LS cord-010092-uftc8inx 6371 2 . . . cord-010092-uftc8inx 6372 1 The the DT cord-010092-uftc8inx 6372 2 average average JJ cord-010092-uftc8inx 6372 3 number number NN cord-010092-uftc8inx 6372 4 of of IN cord-010092-uftc8inx 6372 5 platelets platelet NNS cord-010092-uftc8inx 6372 6 after after IN cord-010092-uftc8inx 6372 7 the the DT cord-010092-uftc8inx 6372 8 reconstitution reconstitution NN cord-010092-uftc8inx 6372 9 is be VBZ cord-010092-uftc8inx 6372 10 2.9 2.9 CD cord-010092-uftc8inx 6372 11 9 9 CD cord-010092-uftc8inx 6372 12 10 10 CD cord-010092-uftc8inx 6372 13 11 11 CD cord-010092-uftc8inx 6372 14 /unit /unit , cord-010092-uftc8inx 6372 15 , , , cord-010092-uftc8inx 6372 16 which which WDT cord-010092-uftc8inx 6372 17 slightly slightly RB cord-010092-uftc8inx 6372 18 deviates deviate VBZ cord-010092-uftc8inx 6372 19 from from IN cord-010092-uftc8inx 6372 20 the the DT cord-010092-uftc8inx 6372 21 quality quality NN cord-010092-uftc8inx 6372 22 requirements requirement NNS cord-010092-uftc8inx 6372 23 . . . cord-010092-uftc8inx 6373 1 5 5 LS cord-010092-uftc8inx 6373 2 . . . cord-010092-uftc8inx 6374 1 The the DT cord-010092-uftc8inx 6374 2 results result NNS cord-010092-uftc8inx 6374 3 that that WDT cord-010092-uftc8inx 6374 4 we -PRON- PRP cord-010092-uftc8inx 6374 5 obtained obtain VBD cord-010092-uftc8inx 6374 6 show show VBP cord-010092-uftc8inx 6374 7 that that IN cord-010092-uftc8inx 6374 8 the the DT cord-010092-uftc8inx 6374 9 process process NN cord-010092-uftc8inx 6374 10 of of IN cord-010092-uftc8inx 6374 11 reconstitution reconstitution NN cord-010092-uftc8inx 6374 12 always always RB cord-010092-uftc8inx 6374 13 results result VBZ cord-010092-uftc8inx 6374 14 in in IN cord-010092-uftc8inx 6374 15 the the DT cord-010092-uftc8inx 6374 16 loss loss NN cord-010092-uftc8inx 6374 17 of of IN cord-010092-uftc8inx 6374 18 number number NN cord-010092-uftc8inx 6374 19 of of IN cord-010092-uftc8inx 6374 20 platelets platelet NNS cord-010092-uftc8inx 6374 21 and and CC cord-010092-uftc8inx 6374 22 that that IN cord-010092-uftc8inx 6374 23 the the DT cord-010092-uftc8inx 6374 24 quality quality NN cord-010092-uftc8inx 6374 25 of of IN cord-010092-uftc8inx 6374 26 platelet platelet NN cord-010092-uftc8inx 6374 27 concentrates concentrate VBZ cord-010092-uftc8inx 6374 28 that that WDT cord-010092-uftc8inx 6374 29 have have VBP cord-010092-uftc8inx 6374 30 not not RB cord-010092-uftc8inx 6374 31 been be VBN cord-010092-uftc8inx 6374 32 reprocessed reprocess VBN cord-010092-uftc8inx 6374 33 is be VBZ cord-010092-uftc8inx 6374 34 always always RB cord-010092-uftc8inx 6374 35 higher high JJR cord-010092-uftc8inx 6374 36 . . . cord-010092-uftc8inx 6375 1 Because because IN cord-010092-uftc8inx 6375 2 of of IN cord-010092-uftc8inx 6375 3 that that DT cord-010092-uftc8inx 6375 4 we -PRON- PRP cord-010092-uftc8inx 6375 5 recommend recommend VBP cord-010092-uftc8inx 6375 6 that that IN cord-010092-uftc8inx 6375 7 the the DT cord-010092-uftc8inx 6375 8 reconstitution reconstitution NN cord-010092-uftc8inx 6375 9 should should MD cord-010092-uftc8inx 6375 10 only only RB cord-010092-uftc8inx 6375 11 be be VB cord-010092-uftc8inx 6375 12 performed perform VBN cord-010092-uftc8inx 6375 13 in in IN cord-010092-uftc8inx 6375 14 special special JJ cord-010092-uftc8inx 6375 15 cases case NNS cord-010092-uftc8inx 6375 16 such such JJ cord-010092-uftc8inx 6375 17 as as IN cord-010092-uftc8inx 6375 18 for for IN cord-010092-uftc8inx 6375 19 patients patient NNS cord-010092-uftc8inx 6375 20 after after IN cord-010092-uftc8inx 6375 21 stem stem NN cord-010092-uftc8inx 6375 22 cell cell NN cord-010092-uftc8inx 6375 23 transplant transplant NN cord-010092-uftc8inx 6375 24 incompatible incompatible JJ cord-010092-uftc8inx 6375 25 with with IN cord-010092-uftc8inx 6375 26 their -PRON- PRP$ cord-010092-uftc8inx 6375 27 blood blood NN cord-010092-uftc8inx 6375 28 group group NN cord-010092-uftc8inx 6375 29 and and CC cord-010092-uftc8inx 6375 30 that that IN cord-010092-uftc8inx 6375 31 hospitals hospital NNS cord-010092-uftc8inx 6375 32 should should MD cord-010092-uftc8inx 6375 33 be be VB cord-010092-uftc8inx 6375 34 supplied supply VBN cord-010092-uftc8inx 6375 35 with with IN cord-010092-uftc8inx 6375 36 platelet platelet NN cord-010092-uftc8inx 6375 37 concentrates concentrate VBZ cord-010092-uftc8inx 6375 38 derived derive VBN cord-010092-uftc8inx 6375 39 from from IN cord-010092-uftc8inx 6375 40 buffy buffy NNP cord-010092-uftc8inx 6375 41 coats coat NNS cord-010092-uftc8inx 6375 42 and and CC cord-010092-uftc8inx 6375 43 apheresis apheresis NN cord-010092-uftc8inx 6375 44 . . . cord-010092-uftc8inx 6376 1 Methods method NNS cord-010092-uftc8inx 6376 2 : : : cord-010092-uftc8inx 6376 3 PF4 pf4 NN cord-010092-uftc8inx 6376 4 was be VBD cord-010092-uftc8inx 6376 5 extracted extract VBN cord-010092-uftc8inx 6376 6 from from IN cord-010092-uftc8inx 6376 7 human human JJ cord-010092-uftc8inx 6376 8 PCs pc NNS cord-010092-uftc8inx 6376 9 by by IN cord-010092-uftc8inx 6376 10 using use VBG cord-010092-uftc8inx 6376 11 immunoaffinity immunoaffinity NN cord-010092-uftc8inx 6376 12 chromatography chromatography NN cord-010092-uftc8inx 6376 13 and and CC cord-010092-uftc8inx 6376 14 specific specific JJ cord-010092-uftc8inx 6376 15 anti anti JJ cord-010092-uftc8inx 6376 16 - - JJ cord-010092-uftc8inx 6376 17 PF4 pf4 JJ cord-010092-uftc8inx 6376 18 antibody antibody NN cord-010092-uftc8inx 6376 19 on on IN cord-010092-uftc8inx 6376 20 the the DT cord-010092-uftc8inx 6376 21 column column NN cord-010092-uftc8inx 6376 22 . . . cord-010092-uftc8inx 6377 1 Hereafter hereafter RB cord-010092-uftc8inx 6377 2 , , , cord-010092-uftc8inx 6377 3 PF4 pf4 NN cord-010092-uftc8inx 6377 4 was be VBD cord-010092-uftc8inx 6377 5 purified purify VBN cord-010092-uftc8inx 6377 6 with with IN cord-010092-uftc8inx 6377 7 concentration concentration NN cord-010092-uftc8inx 6377 8 tubes tube NNS cord-010092-uftc8inx 6377 9 having have VBG cord-010092-uftc8inx 6377 10 5 5 CD cord-010092-uftc8inx 6377 11 kDa kDa NNP cord-010092-uftc8inx 6377 12 molecular molecular JJ cord-010092-uftc8inx 6377 13 weight weight NN cord-010092-uftc8inx 6377 14 cut cut NN cord-010092-uftc8inx 6377 15 - - HYPH cord-010092-uftc8inx 6377 16 off off NN cord-010092-uftc8inx 6377 17 and and CC cord-010092-uftc8inx 6377 18 dialyzed dialyze VBN cord-010092-uftc8inx 6377 19 via via IN cord-010092-uftc8inx 6377 20 dialysis dialysis NN cord-010092-uftc8inx 6377 21 tubing tubing NN cord-010092-uftc8inx 6377 22 with with IN cord-010092-uftc8inx 6377 23 3.5 3.5 CD cord-010092-uftc8inx 6377 24 kDa kDa NNS cord-010092-uftc8inx 6377 25 cut cut VBN cord-010092-uftc8inx 6377 26 - - HYPH cord-010092-uftc8inx 6377 27 off off NN cord-010092-uftc8inx 6377 28 . . . cord-010092-uftc8inx 6378 1 PF4 pf4 JJ cord-010092-uftc8inx 6378 2 concentration concentration NN cord-010092-uftc8inx 6378 3 was be VBD cord-010092-uftc8inx 6378 4 measured measure VBN cord-010092-uftc8inx 6378 5 by by IN cord-010092-uftc8inx 6378 6 Bradford Bradford NNP cord-010092-uftc8inx 6378 7 method method NN cord-010092-uftc8inx 6378 8 . . . cord-010092-uftc8inx 6379 1 Specific specific JJ cord-010092-uftc8inx 6379 2 enzyme enzyme NN cord-010092-uftc8inx 6379 3 - - HYPH cord-010092-uftc8inx 6379 4 linked link VBN cord-010092-uftc8inx 6379 5 immunosorbent immunosorbent JJ cord-010092-uftc8inx 6379 6 assay assay NN cord-010092-uftc8inx 6379 7 ( ( -LRB- cord-010092-uftc8inx 6379 8 ELISA ELISA NNP cord-010092-uftc8inx 6379 9 ) ) -RRB- cord-010092-uftc8inx 6379 10 and and CC cord-010092-uftc8inx 6379 11 dot dot NN cord-010092-uftc8inx 6379 12 blot blot NN cord-010092-uftc8inx 6379 13 analysis analysis NN cord-010092-uftc8inx 6379 14 were be VBD cord-010092-uftc8inx 6379 15 used use VBN cord-010092-uftc8inx 6379 16 to to TO cord-010092-uftc8inx 6379 17 determine determine VB cord-010092-uftc8inx 6379 18 the the DT cord-010092-uftc8inx 6379 19 PF4 pf4 JJ cord-010092-uftc8inx 6379 20 specificity specificity NN cord-010092-uftc8inx 6379 21 . . . cord-010092-uftc8inx 6380 1 Molecular molecular JJ cord-010092-uftc8inx 6380 2 weight weight NN cord-010092-uftc8inx 6380 3 of of IN cord-010092-uftc8inx 6380 4 obtained obtain VBN cord-010092-uftc8inx 6380 5 PF4 PF4 NNP cord-010092-uftc8inx 6380 6 was be VBD cord-010092-uftc8inx 6380 7 determined determine VBN cord-010092-uftc8inx 6380 8 by by IN cord-010092-uftc8inx 6380 9 polyacrylamide polyacrylamide NN cord-010092-uftc8inx 6380 10 gel gel NN cord-010092-uftc8inx 6380 11 electrophoresis electrophoresis NN cord-010092-uftc8inx 6380 12 ( ( -LRB- cord-010092-uftc8inx 6380 13 PAGE page NN cord-010092-uftc8inx 6380 14 ) ) -RRB- cord-010092-uftc8inx 6380 15 . . . cord-010092-uftc8inx 6381 1 Results result NNS cord-010092-uftc8inx 6381 2 : : : cord-010092-uftc8inx 6382 1 Our -PRON- PRP$ cord-010092-uftc8inx 6382 2 data datum NNS cord-010092-uftc8inx 6382 3 confirmed confirm VBD cord-010092-uftc8inx 6382 4 clearly clearly RB cord-010092-uftc8inx 6382 5 that that WDT cord-010092-uftc8inx 6382 6 separated separate VBD cord-010092-uftc8inx 6382 7 PF4 PF4 NNP cord-010092-uftc8inx 6382 8 had have VBD cord-010092-uftc8inx 6382 9 30 30 CD cord-010092-uftc8inx 6382 10 kDa kDa NNP cord-010092-uftc8inx 6382 11 molecular molecular JJ cord-010092-uftc8inx 6382 12 weight weight NN cord-010092-uftc8inx 6382 13 which which WDT cord-010092-uftc8inx 6382 14 is be VBZ cord-010092-uftc8inx 6382 15 corresponding correspond VBG cord-010092-uftc8inx 6382 16 with with IN cord-010092-uftc8inx 6382 17 a a DT cord-010092-uftc8inx 6382 18 tetramer tetramer NN cord-010092-uftc8inx 6382 19 PF4 pf4 NN cord-010092-uftc8inx 6382 20 . . . cord-010092-uftc8inx 6383 1 In in IN cord-010092-uftc8inx 6383 2 addition addition NN cord-010092-uftc8inx 6383 3 , , , cord-010092-uftc8inx 6383 4 ELISA ELISA NNP cord-010092-uftc8inx 6383 5 showed show VBD cord-010092-uftc8inx 6383 6 that that IN cord-010092-uftc8inx 6383 7 the the DT cord-010092-uftc8inx 6383 8 PF4 pf4 RB cord-010092-uftc8inx 6383 9 qualified qualified JJ cord-010092-uftc8inx 6383 10 true true JJ cord-010092-uftc8inx 6383 11 antigenicity antigenicity NN cord-010092-uftc8inx 6383 12 . . . cord-010092-uftc8inx 6384 1 Dot dot NN cord-010092-uftc8inx 6384 2 blot blot NN cord-010092-uftc8inx 6384 3 analysis analysis NN cord-010092-uftc8inx 6384 4 helped help VBD cord-010092-uftc8inx 6384 5 us -PRON- PRP cord-010092-uftc8inx 6384 6 to to TO cord-010092-uftc8inx 6384 7 assure assure VB cord-010092-uftc8inx 6384 8 the the DT cord-010092-uftc8inx 6384 9 specificity specificity NN cord-010092-uftc8inx 6384 10 of of IN cord-010092-uftc8inx 6384 11 PF4 pf4 NN cord-010092-uftc8inx 6384 12 . . . cord-010092-uftc8inx 6385 1 Summary Summary NNP cord-010092-uftc8inx 6385 2 / / SYM cord-010092-uftc8inx 6385 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 6385 4 : : : cord-010092-uftc8inx 6386 1 We -PRON- PRP cord-010092-uftc8inx 6386 2 used use VBD cord-010092-uftc8inx 6386 3 and and CC cord-010092-uftc8inx 6386 4 optimized optimize VBD cord-010092-uftc8inx 6386 5 a a DT cord-010092-uftc8inx 6386 6 homemade homemade JJ cord-010092-uftc8inx 6386 7 protocol protocol NN cord-010092-uftc8inx 6386 8 to to TO cord-010092-uftc8inx 6386 9 isolate isolate VB cord-010092-uftc8inx 6386 10 and and CC cord-010092-uftc8inx 6386 11 purify purify VB cord-010092-uftc8inx 6386 12 the the DT cord-010092-uftc8inx 6386 13 PF4 pf4 NN cord-010092-uftc8inx 6386 14 . . . cord-010092-uftc8inx 6387 1 Nevertheless nevertheless RB cord-010092-uftc8inx 6387 2 , , , cord-010092-uftc8inx 6387 3 there there EX cord-010092-uftc8inx 6387 4 was be VBD cord-010092-uftc8inx 6387 5 no no DT cord-010092-uftc8inx 6387 6 any any DT cord-010092-uftc8inx 6387 7 scientific scientific JJ cord-010092-uftc8inx 6387 8 report report NN cord-010092-uftc8inx 6387 9 among among IN cord-010092-uftc8inx 6387 10 the the DT cord-010092-uftc8inx 6387 11 databases database NNS cord-010092-uftc8inx 6387 12 that that WDT cord-010092-uftc8inx 6387 13 utilized utilize VBD cord-010092-uftc8inx 6387 14 the the DT cord-010092-uftc8inx 6387 15 similar similar JJ cord-010092-uftc8inx 6387 16 purification purification NN cord-010092-uftc8inx 6387 17 method method NN cord-010092-uftc8inx 6387 18 . . . cord-010092-uftc8inx 6388 1 Recombinant recombinant JJ cord-010092-uftc8inx 6388 2 PF4 pf4 NN cord-010092-uftc8inx 6388 3 is be VBZ cord-010092-uftc8inx 6388 4 more more RBR cord-010092-uftc8inx 6388 5 feasible feasible JJ cord-010092-uftc8inx 6388 6 and and CC cord-010092-uftc8inx 6388 7 ready ready JJ cord-010092-uftc8inx 6388 8 - - HYPH cord-010092-uftc8inx 6388 9 to to IN cord-010092-uftc8inx 6388 10 - - HYPH cord-010092-uftc8inx 6388 11 use use NN cord-010092-uftc8inx 6388 12 , , , cord-010092-uftc8inx 6388 13 but but CC cord-010092-uftc8inx 6388 14 its -PRON- PRP$ cord-010092-uftc8inx 6388 15 price price NN cord-010092-uftc8inx 6388 16 may may MD cord-010092-uftc8inx 6388 17 discourage discourage VB cord-010092-uftc8inx 6388 18 the the DT cord-010092-uftc8inx 6388 19 researchers researcher NNS cord-010092-uftc8inx 6388 20 to to TO cord-010092-uftc8inx 6388 21 study study VB cord-010092-uftc8inx 6388 22 the the DT cord-010092-uftc8inx 6388 23 biology biology NN cord-010092-uftc8inx 6388 24 of of IN cord-010092-uftc8inx 6388 25 PF4 pf4 NN cord-010092-uftc8inx 6388 26 . . . cord-010092-uftc8inx 6389 1 Unused unused JJ cord-010092-uftc8inx 6389 2 human human JJ cord-010092-uftc8inx 6389 3 PCs pc NNS cord-010092-uftc8inx 6389 4 and and CC cord-010092-uftc8inx 6389 5 specific specific JJ cord-010092-uftc8inx 6389 6 anti anti JJ cord-010092-uftc8inx 6389 7 - - JJ cord-010092-uftc8inx 6389 8 PF4 pf4 JJ cord-010092-uftc8inx 6389 9 antibody antibody NN cord-010092-uftc8inx 6389 10 can can MD cord-010092-uftc8inx 6389 11 considered consider VBN cord-010092-uftc8inx 6389 12 as as IN cord-010092-uftc8inx 6389 13 an an DT cord-010092-uftc8inx 6389 14 alternative alternative NN cord-010092-uftc8inx 6389 15 to to TO cord-010092-uftc8inx 6389 16 separate separate VB cord-010092-uftc8inx 6389 17 the the DT cord-010092-uftc8inx 6389 18 PF4 pf4 NN cord-010092-uftc8inx 6389 19 particularly particularly RB cord-010092-uftc8inx 6389 20 in in IN cord-010092-uftc8inx 6389 21 labs lab NNS cord-010092-uftc8inx 6389 22 with with IN cord-010092-uftc8inx 6389 23 the the DT cord-010092-uftc8inx 6389 24 shortage shortage NN cord-010092-uftc8inx 6389 25 of of IN cord-010092-uftc8inx 6389 26 resources resource NNS cord-010092-uftc8inx 6389 27 . . . cord-010092-uftc8inx 6390 1 Background background NN cord-010092-uftc8inx 6390 2 : : : cord-010092-uftc8inx 6391 1 Whole whole JJ cord-010092-uftc8inx 6391 2 blood blood NN cord-010092-uftc8inx 6391 3 is be VBZ cord-010092-uftc8inx 6391 4 increasingly increasingly RB cord-010092-uftc8inx 6391 5 used use VBN cord-010092-uftc8inx 6391 6 in in IN cord-010092-uftc8inx 6391 7 civilian civilian JJ cord-010092-uftc8inx 6391 8 hospitals hospital NNS cord-010092-uftc8inx 6391 9 as as IN cord-010092-uftc8inx 6391 10 an an DT cord-010092-uftc8inx 6391 11 alternative alternative NN cord-010092-uftc8inx 6391 12 to to IN cord-010092-uftc8inx 6391 13 blood blood NN cord-010092-uftc8inx 6391 14 components component NNS cord-010092-uftc8inx 6391 15 in in IN cord-010092-uftc8inx 6391 16 trauma trauma NN cord-010092-uftc8inx 6391 17 resuscitation resuscitation NN cord-010092-uftc8inx 6391 18 with with IN cord-010092-uftc8inx 6391 19 massive massive JJ cord-010092-uftc8inx 6391 20 bleeding bleeding NN cord-010092-uftc8inx 6391 21 . . . cord-010092-uftc8inx 6392 1 However however RB cord-010092-uftc8inx 6392 2 , , , cord-010092-uftc8inx 6392 3 the the DT cord-010092-uftc8inx 6392 4 hemostatic hemostatic JJ cord-010092-uftc8inx 6392 5 effect effect NN cord-010092-uftc8inx 6392 6 of of IN cord-010092-uftc8inx 6392 7 whole whole JJ cord-010092-uftc8inx 6392 8 blood blood NN cord-010092-uftc8inx 6392 9 depends depend VBZ cord-010092-uftc8inx 6392 10 on on IN cord-010092-uftc8inx 6392 11 the the DT cord-010092-uftc8inx 6392 12 initial initial JJ cord-010092-uftc8inx 6392 13 platelet platelet NN cord-010092-uftc8inx 6392 14 content content NN cord-010092-uftc8inx 6392 15 and and CC cord-010092-uftc8inx 6392 16 decreases decrease VBZ cord-010092-uftc8inx 6392 17 rapidly rapidly RB cord-010092-uftc8inx 6392 18 within within IN cord-010092-uftc8inx 6392 19 the the DT cord-010092-uftc8inx 6392 20 first first JJ cord-010092-uftc8inx 6392 21 2 2 CD cord-010092-uftc8inx 6392 22 weeks week NNS cord-010092-uftc8inx 6392 23 of of IN cord-010092-uftc8inx 6392 24 storage storage NN cord-010092-uftc8inx 6392 25 at at IN cord-010092-uftc8inx 6392 26 4 4 CD cord-010092-uftc8inx 6392 27 ° ° NN cord-010092-uftc8inx 6392 28 C c NN cord-010092-uftc8inx 6392 29 . . . cord-010092-uftc8inx 6393 1 Consequently consequently RB cord-010092-uftc8inx 6393 2 the the DT cord-010092-uftc8inx 6393 3 problem problem NN cord-010092-uftc8inx 6393 4 arises arise VBZ cord-010092-uftc8inx 6393 5 of of IN cord-010092-uftc8inx 6393 6 how how WRB cord-010092-uftc8inx 6393 7 to to TO cord-010092-uftc8inx 6393 8 provide provide VB cord-010092-uftc8inx 6393 9 WB WB NNP cord-010092-uftc8inx 6393 10 to to IN cord-010092-uftc8inx 6393 11 trauma trauma NN cord-010092-uftc8inx 6393 12 centers center NNS cord-010092-uftc8inx 6393 13 without without IN cord-010092-uftc8inx 6393 14 losing lose VBG cord-010092-uftc8inx 6393 15 valuable valuable JJ cord-010092-uftc8inx 6393 16 low low JJ cord-010092-uftc8inx 6393 17 titer titer NN cord-010092-uftc8inx 6393 18 group group NN cord-010092-uftc8inx 6393 19 O o NN cord-010092-uftc8inx 6393 20 units unit NNS cord-010092-uftc8inx 6393 21 if if IN cord-010092-uftc8inx 6393 22 the the DT cord-010092-uftc8inx 6393 23 units unit NNS cord-010092-uftc8inx 6393 24 are be VBP cord-010092-uftc8inx 6393 25 not not RB cord-010092-uftc8inx 6393 26 used use VBN cord-010092-uftc8inx 6393 27 within within IN cord-010092-uftc8inx 6393 28 the the DT cord-010092-uftc8inx 6393 29 expiry expiry NN cord-010092-uftc8inx 6393 30 date date NN cord-010092-uftc8inx 6393 31 of of IN cord-010092-uftc8inx 6393 32 use use NN cord-010092-uftc8inx 6393 33 . . . cord-010092-uftc8inx 6394 1 Aims aim VBZ cord-010092-uftc8inx 6394 2 : : : cord-010092-uftc8inx 6394 3 To to TO cord-010092-uftc8inx 6394 4 assess assess VB cord-010092-uftc8inx 6394 5 the the DT cord-010092-uftc8inx 6394 6 in in IN cord-010092-uftc8inx 6394 7 - - HYPH cord-010092-uftc8inx 6394 8 vitro vitro FW cord-010092-uftc8inx 6394 9 quality quality NN cord-010092-uftc8inx 6394 10 of of IN cord-010092-uftc8inx 6394 11 Red Red NNP cord-010092-uftc8inx 6394 12 Cell Cell NNP cord-010092-uftc8inx 6394 13 Concentrates concentrate VBZ cord-010092-uftc8inx 6394 14 ( ( -LRB- cord-010092-uftc8inx 6394 15 RCC RCC NNP cord-010092-uftc8inx 6394 16 ) ) -RRB- cord-010092-uftc8inx 6394 17 produced produce VBD cord-010092-uftc8inx 6394 18 from from IN cord-010092-uftc8inx 6394 19 7 7 CD cord-010092-uftc8inx 6394 20 days day NNS cord-010092-uftc8inx 6394 21 cold cold JJ cord-010092-uftc8inx 6394 22 stored store VBN cord-010092-uftc8inx 6394 23 leucodepleted leucodepleted JJ cord-010092-uftc8inx 6394 24 whole whole JJ cord-010092-uftc8inx 6394 25 blood blood NN cord-010092-uftc8inx 6394 26 units unit NNS cord-010092-uftc8inx 6394 27 filtered filter VBN cord-010092-uftc8inx 6394 28 with with IN cord-010092-uftc8inx 6394 29 a a DT cord-010092-uftc8inx 6394 30 platelet platelet NN cord-010092-uftc8inx 6394 31 - - HYPH cord-010092-uftc8inx 6394 32 sparing spare VBG cord-010092-uftc8inx 6394 33 whole whole JJ cord-010092-uftc8inx 6394 34 blood blood NN cord-010092-uftc8inx 6394 35 filtration filtration NN cord-010092-uftc8inx 6394 36 filter filter NN cord-010092-uftc8inx 6394 37 in in IN cord-010092-uftc8inx 6394 38 order order NN cord-010092-uftc8inx 6394 39 to to TO cord-010092-uftc8inx 6394 40 save save VB cord-010092-uftc8inx 6394 41 the the DT cord-010092-uftc8inx 6394 42 RCC RCC NNP cord-010092-uftc8inx 6394 43 once once IN cord-010092-uftc8inx 6394 44 the the DT cord-010092-uftc8inx 6394 45 WB WB NNP cord-010092-uftc8inx 6394 46 units unit NNS cord-010092-uftc8inx 6394 47 has have VBZ cord-010092-uftc8inx 6394 48 reached reach VBN cord-010092-uftc8inx 6394 49 the the DT cord-010092-uftc8inx 6394 50 expiry expiry NN cord-010092-uftc8inx 6394 51 date date NN cord-010092-uftc8inx 6394 52 . . . cord-010092-uftc8inx 6395 1 Methods method NNS cord-010092-uftc8inx 6395 2 : : : cord-010092-uftc8inx 6395 3 34 34 CD cord-010092-uftc8inx 6395 4 units unit NNS cord-010092-uftc8inx 6395 5 of of IN cord-010092-uftc8inx 6395 6 whole whole JJ cord-010092-uftc8inx 6395 7 blood blood NN cord-010092-uftc8inx 6395 8 were be VBD cord-010092-uftc8inx 6395 9 leucodepleted leucodeplete VBN cord-010092-uftc8inx 6395 10 within within IN cord-010092-uftc8inx 6395 11 24 24 CD cord-010092-uftc8inx 6395 12 h h NN cord-010092-uftc8inx 6395 13 using use VBG cord-010092-uftc8inx 6395 14 a a DT cord-010092-uftc8inx 6395 15 platelet platelet NN cord-010092-uftc8inx 6395 16 sparing spare VBG cord-010092-uftc8inx 6395 17 filter filter NN cord-010092-uftc8inx 6395 18 ( ( -LRB- cord-010092-uftc8inx 6395 19 Imuflex Imuflex NNP cord-010092-uftc8inx 6395 20 WB WB NNP cord-010092-uftc8inx 6395 21 - - HYPH cord-010092-uftc8inx 6395 22 SP SP NNP cord-010092-uftc8inx 6395 23 / / SYM cord-010092-uftc8inx 6395 24 Terumo Terumo NNP cord-010092-uftc8inx 6395 25 BCT BCT NNP cord-010092-uftc8inx 6395 26 ) ) -RRB- cord-010092-uftc8inx 6395 27 and and CC cord-010092-uftc8inx 6395 28 stored store VBN cord-010092-uftc8inx 6395 29 for for IN cord-010092-uftc8inx 6395 30 7 7 CD cord-010092-uftc8inx 6395 31 days day NNS cord-010092-uftc8inx 6395 32 at at IN cord-010092-uftc8inx 6395 33 4 4 CD cord-010092-uftc8inx 6395 34 AE AE NNP cord-010092-uftc8inx 6395 35 2 2 CD cord-010092-uftc8inx 6395 36 ° ° NN cord-010092-uftc8inx 6395 37 C c NN cord-010092-uftc8inx 6395 38 . . . cord-010092-uftc8inx 6396 1 On on IN cord-010092-uftc8inx 6396 2 the the DT cord-010092-uftc8inx 6396 3 8 8 CD cord-010092-uftc8inx 6396 4 th th CD cord-010092-uftc8inx 6396 5 day day NN cord-010092-uftc8inx 6396 6 of of IN cord-010092-uftc8inx 6396 7 storage storage NN cord-010092-uftc8inx 6396 8 , , , cord-010092-uftc8inx 6396 9 units unit NNS cord-010092-uftc8inx 6396 10 are be VBP cord-010092-uftc8inx 6396 11 centrifuged centrifuge VBN cord-010092-uftc8inx 6396 12 and and CC cord-010092-uftc8inx 6396 13 the the DT cord-010092-uftc8inx 6396 14 RCC RCC NNP cord-010092-uftc8inx 6396 15 is be VBZ cord-010092-uftc8inx 6396 16 supplemented supplement VBN cord-010092-uftc8inx 6396 17 with with IN cord-010092-uftc8inx 6396 18 SAG SAG NNP cord-010092-uftc8inx 6396 19 - - HYPH cord-010092-uftc8inx 6396 20 M M NNP cord-010092-uftc8inx 6396 21 additive additive NN cord-010092-uftc8inx 6396 22 solution solution NN cord-010092-uftc8inx 6396 23 for for IN cord-010092-uftc8inx 6396 24 an an DT cord-010092-uftc8inx 6396 25 additional additional JJ cord-010092-uftc8inx 6396 26 storage storage NN cord-010092-uftc8inx 6396 27 of of IN cord-010092-uftc8inx 6396 28 35 35 CD cord-010092-uftc8inx 6396 29 days day NNS cord-010092-uftc8inx 6396 30 at at IN cord-010092-uftc8inx 6396 31 4 4 CD cord-010092-uftc8inx 6396 32 AE AE NNP cord-010092-uftc8inx 6396 33 2 2 CD cord-010092-uftc8inx 6396 34 ° ° NN cord-010092-uftc8inx 6396 35 C c NN cord-010092-uftc8inx 6396 36 . . . cord-010092-uftc8inx 6397 1 In in IN cord-010092-uftc8inx 6397 2 vitro vitro FW cord-010092-uftc8inx 6397 3 parameters parameter NNS cord-010092-uftc8inx 6397 4 such such JJ cord-010092-uftc8inx 6397 5 as as IN cord-010092-uftc8inx 6397 6 hemoglobin hemoglobin NN cord-010092-uftc8inx 6397 7 , , , cord-010092-uftc8inx 6397 8 hematocrit hematocrit NN cord-010092-uftc8inx 6397 9 , , , cord-010092-uftc8inx 6397 10 residual residual JJ cord-010092-uftc8inx 6397 11 leucocytes leucocyte NNS cord-010092-uftc8inx 6397 12 , , , cord-010092-uftc8inx 6397 13 platelet platelet NN cord-010092-uftc8inx 6397 14 content content NN cord-010092-uftc8inx 6397 15 , , , cord-010092-uftc8inx 6397 16 hemolysis hemolysis NN cord-010092-uftc8inx 6397 17 , , , cord-010092-uftc8inx 6397 18 glucose glucose NN cord-010092-uftc8inx 6397 19 , , , cord-010092-uftc8inx 6397 20 lactate lactate NN cord-010092-uftc8inx 6397 21 , , , cord-010092-uftc8inx 6397 22 ATP ATP NNP cord-010092-uftc8inx 6397 23 , , , cord-010092-uftc8inx 6397 24 2.3 2.3 CD cord-010092-uftc8inx 6397 25 DPG DPG NNP cord-010092-uftc8inx 6397 26 were be VBD cord-010092-uftc8inx 6397 27 tested test VBN cord-010092-uftc8inx 6397 28 during during IN cord-010092-uftc8inx 6397 29 storage storage NN cord-010092-uftc8inx 6397 30 . . . cord-010092-uftc8inx 6398 1 Results result NNS cord-010092-uftc8inx 6398 2 : : : cord-010092-uftc8inx 6399 1 The the DT cord-010092-uftc8inx 6399 2 Imuflex Imuflex NNP cord-010092-uftc8inx 6399 3 WB WB NNP cord-010092-uftc8inx 6399 4 - - HYPH cord-010092-uftc8inx 6399 5 SP SP NNP cord-010092-uftc8inx 6399 6 provided provide VBD cord-010092-uftc8inx 6399 7 satisfying satisfy VBG cord-010092-uftc8inx 6399 8 leucodepletion leucodepletion NN cord-010092-uftc8inx 6399 9 of of IN cord-010092-uftc8inx 6399 10 the the DT cord-010092-uftc8inx 6399 11 WB WB NNP cord-010092-uftc8inx 6399 12 units unit NNS cord-010092-uftc8inx 6399 13 ( ( -LRB- cord-010092-uftc8inx 6399 14 0.23 0.23 CD cord-010092-uftc8inx 6399 15 AE AE NNP cord-010092-uftc8inx 6399 16 0.2.10e6 0.2.10e6 CD cord-010092-uftc8inx 6399 17 / / SYM cord-010092-uftc8inx 6399 18 U U NNP cord-010092-uftc8inx 6399 19 ) ) -RRB- cord-010092-uftc8inx 6399 20 ) ) -RRB- cord-010092-uftc8inx 6399 21 while while IN cord-010092-uftc8inx 6399 22 maintaining maintain VBG cord-010092-uftc8inx 6399 23 80 80 CD cord-010092-uftc8inx 6399 24 % % NN cord-010092-uftc8inx 6399 25 of of IN cord-010092-uftc8inx 6399 26 the the DT cord-010092-uftc8inx 6399 27 initial initial JJ cord-010092-uftc8inx 6399 28 platelet platelet NN cord-010092-uftc8inx 6399 29 content content NN cord-010092-uftc8inx 6399 30 ( ( -LRB- cord-010092-uftc8inx 6399 31 85 85 CD cord-010092-uftc8inx 6399 32 AE AE NNP cord-010092-uftc8inx 6399 33 20.10e9 20.10e9 CD cord-010092-uftc8inx 6399 34 / / SYM cord-010092-uftc8inx 6399 35 U U NNP cord-010092-uftc8inx 6399 36 ) ) -RRB- cord-010092-uftc8inx 6399 37 . . . cord-010092-uftc8inx 6400 1 Mean mean JJ cord-010092-uftc8inx 6400 2 volume volume NN cord-010092-uftc8inx 6400 3 ( ( -LRB- cord-010092-uftc8inx 6400 4 464 464 CD cord-010092-uftc8inx 6400 5 AE AE NNP cord-010092-uftc8inx 6400 6 24 24 CD cord-010092-uftc8inx 6400 7 mL ml NN cord-010092-uftc8inx 6400 8 ) ) -RRB- cord-010092-uftc8inx 6400 9 , , , cord-010092-uftc8inx 6400 10 hemoglobin hemoglobin NN cord-010092-uftc8inx 6400 11 content content NN cord-010092-uftc8inx 6400 12 ( ( -LRB- cord-010092-uftc8inx 6400 13 54 54 CD cord-010092-uftc8inx 6400 14 AE AE NNP cord-010092-uftc8inx 6400 15 6 6 CD cord-010092-uftc8inx 6400 16 g g NN cord-010092-uftc8inx 6400 17 / / SYM cord-010092-uftc8inx 6400 18 U U NNP cord-010092-uftc8inx 6400 19 ) ) -RRB- cord-010092-uftc8inx 6400 20 and and CC cord-010092-uftc8inx 6400 21 hematocrit hematocrit NN cord-010092-uftc8inx 6400 22 ( ( -LRB- cord-010092-uftc8inx 6400 23 36 36 CD cord-010092-uftc8inx 6400 24 AE AE NNP cord-010092-uftc8inx 6400 25 3 3 CD cord-010092-uftc8inx 6400 26 % % NN cord-010092-uftc8inx 6400 27 ) ) -RRB- cord-010092-uftc8inx 6400 28 was be VBD cord-010092-uftc8inx 6400 29 within within IN cord-010092-uftc8inx 6400 30 conformance conformance NN cord-010092-uftc8inx 6400 31 range range NN cord-010092-uftc8inx 6400 32 . . . cord-010092-uftc8inx 6401 1 After after IN cord-010092-uftc8inx 6401 2 7 7 CD cord-010092-uftc8inx 6401 3 days day NNS cord-010092-uftc8inx 6401 4 of of IN cord-010092-uftc8inx 6401 5 storage storage NN cord-010092-uftc8inx 6401 6 , , , cord-010092-uftc8inx 6401 7 50 50 CD cord-010092-uftc8inx 6401 8 % % NN cord-010092-uftc8inx 6401 9 of of IN cord-010092-uftc8inx 6401 10 the the DT cord-010092-uftc8inx 6401 11 initial initial JJ cord-010092-uftc8inx 6401 12 platelet platelet NN cord-010092-uftc8inx 6401 13 content content NN cord-010092-uftc8inx 6401 14 at at IN cord-010092-uftc8inx 6401 15 collection collection NN cord-010092-uftc8inx 6401 16 is be VBZ cord-010092-uftc8inx 6401 17 maintained maintain VBN cord-010092-uftc8inx 6401 18 and and CC cord-010092-uftc8inx 6401 19 mean mean JJ cord-010092-uftc8inx 6401 20 hemolysis hemolysis NN cord-010092-uftc8inx 6401 21 is be VBZ cord-010092-uftc8inx 6401 22 0.27 0.27 CD cord-010092-uftc8inx 6401 23 AE AE NNP cord-010092-uftc8inx 6401 24 0.15 0.15 CD cord-010092-uftc8inx 6401 25 % % NN cord-010092-uftc8inx 6401 26 . . . cord-010092-uftc8inx 6402 1 RCC RCC NNP cord-010092-uftc8inx 6402 2 processing process VBG cord-010092-uftc8inx 6402 3 at at IN cord-010092-uftc8inx 6402 4 day day NN cord-010092-uftc8inx 6402 5 8 8 CD cord-010092-uftc8inx 6402 6 was be VBD cord-010092-uftc8inx 6402 7 uneventful uneventful JJ cord-010092-uftc8inx 6402 8 , , , cord-010092-uftc8inx 6402 9 without without IN cord-010092-uftc8inx 6402 10 loss loss NN cord-010092-uftc8inx 6402 11 of of IN cord-010092-uftc8inx 6402 12 hemoglobin hemoglobin NN cord-010092-uftc8inx 6402 13 or or CC cord-010092-uftc8inx 6402 14 noticeable noticeable JJ cord-010092-uftc8inx 6402 15 hemolysis hemolysis NN cord-010092-uftc8inx 6402 16 . . . cord-010092-uftc8inx 6403 1 Mean mean JJ cord-010092-uftc8inx 6403 2 volume volume NN cord-010092-uftc8inx 6403 3 ( ( -LRB- cord-010092-uftc8inx 6403 4 266 266 CD cord-010092-uftc8inx 6403 5 AE AE NNP cord-010092-uftc8inx 6403 6 20 20 CD cord-010092-uftc8inx 6403 7 mL ml NN cord-010092-uftc8inx 6403 8 ) ) -RRB- cord-010092-uftc8inx 6403 9 , , , cord-010092-uftc8inx 6403 10 hematocrit hematocrit NN cord-010092-uftc8inx 6403 11 ( ( -LRB- cord-010092-uftc8inx 6403 12 56 56 CD cord-010092-uftc8inx 6403 13 AE AE NNP cord-010092-uftc8inx 6403 14 3 3 CD cord-010092-uftc8inx 6403 15 % % NN cord-010092-uftc8inx 6403 16 ) ) -RRB- cord-010092-uftc8inx 6403 17 , , , cord-010092-uftc8inx 6403 18 hemolysis hemolysis NN cord-010092-uftc8inx 6403 19 ( ( -LRB- cord-010092-uftc8inx 6403 20 0.18 0.18 CD cord-010092-uftc8inx 6403 21 AE AE NNP cord-010092-uftc8inx 6403 22 0.19 0.19 CD cord-010092-uftc8inx 6403 23 % % NN cord-010092-uftc8inx 6403 24 ) ) -RRB- cord-010092-uftc8inx 6403 25 were be VBD cord-010092-uftc8inx 6403 26 in in IN cord-010092-uftc8inx 6403 27 conformance conformance NN cord-010092-uftc8inx 6403 28 with with IN cord-010092-uftc8inx 6403 29 mandatory mandatory JJ cord-010092-uftc8inx 6403 30 standards standard NNS cord-010092-uftc8inx 6403 31 at at IN cord-010092-uftc8inx 6403 32 day day NN cord-010092-uftc8inx 6403 33 8 8 CD cord-010092-uftc8inx 6403 34 . . . cord-010092-uftc8inx 6404 1 After after IN cord-010092-uftc8inx 6404 2 7 7 CD cord-010092-uftc8inx 6404 3 days day NNS cord-010092-uftc8inx 6404 4 of of IN cord-010092-uftc8inx 6404 5 storage storage NN cord-010092-uftc8inx 6404 6 ( ( -LRB- cord-010092-uftc8inx 6404 7 i.e. i.e. FW cord-010092-uftc8inx 6404 8 day day NN cord-010092-uftc8inx 6404 9 14 14 CD cord-010092-uftc8inx 6404 10 after after IN cord-010092-uftc8inx 6404 11 collection collection NN cord-010092-uftc8inx 6404 12 ) ) -RRB- cord-010092-uftc8inx 6404 13 , , , cord-010092-uftc8inx 6404 14 RCC RCC NNP cord-010092-uftc8inx 6404 15 quality quality NN cord-010092-uftc8inx 6404 16 parameters parameter NNS cord-010092-uftc8inx 6404 17 were be VBD cord-010092-uftc8inx 6404 18 maintained maintain VBN cord-010092-uftc8inx 6404 19 with with IN cord-010092-uftc8inx 6404 20 however however RB cord-010092-uftc8inx 6404 21 an an DT cord-010092-uftc8inx 6404 22 increase increase NN cord-010092-uftc8inx 6404 23 in in IN cord-010092-uftc8inx 6404 24 hemolysis hemolysis NN cord-010092-uftc8inx 6404 25 ( ( -LRB- cord-010092-uftc8inx 6404 26 0.34 0.34 CD cord-010092-uftc8inx 6404 27 AE AE NNP cord-010092-uftc8inx 6404 28 0.36 0.36 CD cord-010092-uftc8inx 6404 29 % % NN cord-010092-uftc8inx 6404 30 ) ) -RRB- cord-010092-uftc8inx 6404 31 which which WDT cord-010092-uftc8inx 6404 32 was be VBD cord-010092-uftc8inx 6404 33 above above IN cord-010092-uftc8inx 6404 34 usual usual JJ cord-010092-uftc8inx 6404 35 values value NNS cord-010092-uftc8inx 6404 36 routinely routinely RB cord-010092-uftc8inx 6404 37 observed observe VBD cord-010092-uftc8inx 6404 38 with with IN cord-010092-uftc8inx 6404 39 RCC RCC NNP cord-010092-uftc8inx 6404 40 produced produce VBD cord-010092-uftc8inx 6404 41 from from IN cord-010092-uftc8inx 6404 42 day day NN cord-010092-uftc8inx 6404 43 1 1 CD cord-010092-uftc8inx 6404 44 processed process VBN cord-010092-uftc8inx 6404 45 units unit NNS cord-010092-uftc8inx 6404 46 . . . cord-010092-uftc8inx 6405 1 3 3 CD cord-010092-uftc8inx 6405 2 RCC RCC NNP cord-010092-uftc8inx 6405 3 out out IN cord-010092-uftc8inx 6405 4 of of IN cord-010092-uftc8inx 6405 5 34 34 CD cord-010092-uftc8inx 6405 6 were be VBD cord-010092-uftc8inx 6405 7 above above IN cord-010092-uftc8inx 6405 8 the the DT cord-010092-uftc8inx 6405 9 maximum maximum JJ cord-010092-uftc8inx 6405 10 limit limit NN cord-010092-uftc8inx 6405 11 of of IN cord-010092-uftc8inx 6405 12 0.8 0.8 CD cord-010092-uftc8inx 6405 13 % % NN cord-010092-uftc8inx 6405 14 at at IN cord-010092-uftc8inx 6405 15 day day NN cord-010092-uftc8inx 6405 16 14 14 CD cord-010092-uftc8inx 6405 17 after after IN cord-010092-uftc8inx 6405 18 collection collection NN cord-010092-uftc8inx 6406 1 Such such JJ cord-010092-uftc8inx 6406 2 increased increase VBN cord-010092-uftc8inx 6406 3 hemolysis hemolysis NN cord-010092-uftc8inx 6406 4 was be VBD cord-010092-uftc8inx 6406 5 more more RBR cord-010092-uftc8inx 6406 6 pronounced pronounce VBN cord-010092-uftc8inx 6406 7 at at IN cord-010092-uftc8inx 6406 8 day day NN cord-010092-uftc8inx 6406 9 28 28 CD cord-010092-uftc8inx 6406 10 after after IN cord-010092-uftc8inx 6406 11 collection collection NN cord-010092-uftc8inx 6406 12 ( ( -LRB- cord-010092-uftc8inx 6406 13 0.70 0.70 CD cord-010092-uftc8inx 6406 14 AE AE NNP cord-010092-uftc8inx 6406 15 0.45 0.45 CD cord-010092-uftc8inx 6406 16 % % NN cord-010092-uftc8inx 6406 17 ) ) -RRB- cord-010092-uftc8inx 6406 18 with with IN cord-010092-uftc8inx 6406 19 a a DT cord-010092-uftc8inx 6406 20 proportion proportion NN cord-010092-uftc8inx 6406 21 of of IN cord-010092-uftc8inx 6406 22 RCC RCC NNP cord-010092-uftc8inx 6406 23 with with IN cord-010092-uftc8inx 6406 24 a a DT cord-010092-uftc8inx 6406 25 non non JJ cord-010092-uftc8inx 6406 26 - - JJ cord-010092-uftc8inx 6406 27 conforming conforming JJ cord-010092-uftc8inx 6406 28 hemolysis hemolysis NN cord-010092-uftc8inx 6406 29 ratio ratio NN cord-010092-uftc8inx 6406 30 above above IN cord-010092-uftc8inx 6406 31 the the DT cord-010092-uftc8inx 6406 32 accepted accept VBN cord-010092-uftc8inx 6406 33 threshold threshold NN cord-010092-uftc8inx 6406 34 ( ( -LRB- cord-010092-uftc8inx 6406 35 20 20 CD cord-010092-uftc8inx 6406 36 % % NN cord-010092-uftc8inx 6406 37 of of IN cord-010092-uftc8inx 6406 38 the the DT cord-010092-uftc8inx 6406 39 tested test VBN cord-010092-uftc8inx 6406 40 units unit NNS cord-010092-uftc8inx 6406 41 ) ) -RRB- cord-010092-uftc8inx 6406 42 . . . cord-010092-uftc8inx 6407 1 Summary Summary NNP cord-010092-uftc8inx 6407 2 / / SYM cord-010092-uftc8inx 6407 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 6407 4 : : : cord-010092-uftc8inx 6408 1 RCC RCC NNP cord-010092-uftc8inx 6408 2 units unit NNS cord-010092-uftc8inx 6408 3 can can MD cord-010092-uftc8inx 6408 4 be be VB cord-010092-uftc8inx 6408 5 readily readily RB cord-010092-uftc8inx 6408 6 obtained obtain VBN cord-010092-uftc8inx 6408 7 from from IN cord-010092-uftc8inx 6408 8 leucodepleted leucodepleted JJ cord-010092-uftc8inx 6408 9 WB WB NNP cord-010092-uftc8inx 6408 10 units unit NNS cord-010092-uftc8inx 6408 11 with with IN cord-010092-uftc8inx 6408 12 spared spared JJ cord-010092-uftc8inx 6408 13 platelet platelet NN cord-010092-uftc8inx 6408 14 contents content NNS cord-010092-uftc8inx 6408 15 after after IN cord-010092-uftc8inx 6408 16 7 7 CD cord-010092-uftc8inx 6408 17 days day NNS cord-010092-uftc8inx 6408 18 of of IN cord-010092-uftc8inx 6408 19 cold cold JJ cord-010092-uftc8inx 6408 20 storage storage NN cord-010092-uftc8inx 6408 21 . . . cord-010092-uftc8inx 6409 1 In in IN cord-010092-uftc8inx 6409 2 vitro vitro FW cord-010092-uftc8inx 6409 3 quality quality NN cord-010092-uftc8inx 6409 4 attributes attribute NNS cord-010092-uftc8inx 6409 5 of of IN cord-010092-uftc8inx 6409 6 such such JJ cord-010092-uftc8inx 6409 7 RCC RCC NNP cord-010092-uftc8inx 6409 8 are be VBP cord-010092-uftc8inx 6409 9 within within IN cord-010092-uftc8inx 6409 10 conforming conform VBG cord-010092-uftc8inx 6409 11 ranges range NNS cord-010092-uftc8inx 6409 12 for for IN cord-010092-uftc8inx 6409 13 hemoglobin hemoglobin NN cord-010092-uftc8inx 6409 14 , , , cord-010092-uftc8inx 6409 15 hematocrit hematocrit NN cord-010092-uftc8inx 6409 16 , , , cord-010092-uftc8inx 6409 17 volume volume NN cord-010092-uftc8inx 6409 18 and and CC cord-010092-uftc8inx 6409 19 hemolysis hemolysis NN cord-010092-uftc8inx 6409 20 . . . cord-010092-uftc8inx 6410 1 Hemolysis Hemolysis NNP cord-010092-uftc8inx 6410 2 increases increase VBZ cord-010092-uftc8inx 6410 3 more more RBR cord-010092-uftc8inx 6410 4 rapidly rapidly RB cord-010092-uftc8inx 6410 5 than than IN cord-010092-uftc8inx 6410 6 in in IN cord-010092-uftc8inx 6410 7 standard standard JJ cord-010092-uftc8inx 6410 8 RCC RCC NNP cord-010092-uftc8inx 6410 9 , , , cord-010092-uftc8inx 6410 10 thus thus RB cord-010092-uftc8inx 6410 11 limiting limit VBG cord-010092-uftc8inx 6410 12 the the DT cord-010092-uftc8inx 6410 13 possibility possibility NN cord-010092-uftc8inx 6410 14 of of IN cord-010092-uftc8inx 6410 15 use use NN cord-010092-uftc8inx 6410 16 within within IN cord-010092-uftc8inx 6410 17 21 21 CD cord-010092-uftc8inx 6410 18 days day NNS cord-010092-uftc8inx 6410 19 after after IN cord-010092-uftc8inx 6410 20 collection collection NN cord-010092-uftc8inx 6410 21 . . . cord-010092-uftc8inx 6411 1 Additional additional JJ cord-010092-uftc8inx 6411 2 studies study NNS cord-010092-uftc8inx 6411 3 are be VBP cord-010092-uftc8inx 6411 4 being be VBG cord-010092-uftc8inx 6411 5 initiated initiate VBN cord-010092-uftc8inx 6411 6 to to TO cord-010092-uftc8inx 6411 7 reduce reduce VB cord-010092-uftc8inx 6411 8 hemolysis hemolysis NN cord-010092-uftc8inx 6411 9 during during IN cord-010092-uftc8inx 6411 10 storage storage NN cord-010092-uftc8inx 6411 11 . . . cord-010092-uftc8inx 6412 1 G G NNP cord-010092-uftc8inx 6412 2 Hetland Hetland NNP cord-010092-uftc8inx 6412 3 1,2 1,2 CD cord-010092-uftc8inx 6412 4 , , , cord-010092-uftc8inx 6412 5 F F NNP cord-010092-uftc8inx 6412 6 Mahmood Mahmood NNP cord-010092-uftc8inx 6412 7 3 3 CD cord-010092-uftc8inx 6412 8 , , , cord-010092-uftc8inx 6412 9 L L NNP cord-010092-uftc8inx 6412 10 Nissen Nissen NNP cord-010092-uftc8inx 6412 11 - - HYPH cord-010092-uftc8inx 6412 12 Meyer Meyer NNP cord-010092-uftc8inx 6412 13 1 1 CD cord-010092-uftc8inx 6412 14 and and CC cord-010092-uftc8inx 6412 15 I -PRON- PRP cord-010092-uftc8inx 6412 16 Nentwich Nentwich NNP cord-010092-uftc8inx 6412 17 1 1 CD cord-010092-uftc8inx 6412 18 1 1 CD cord-010092-uftc8inx 6412 19 Immunology Immunology NNP cord-010092-uftc8inx 6412 20 and and CC cord-010092-uftc8inx 6412 21 Transfusion Transfusion NNP cord-010092-uftc8inx 6412 22 Medicine Medicine NNP cord-010092-uftc8inx 6412 23 , , , cord-010092-uftc8inx 6412 24 Oslo Oslo NNP cord-010092-uftc8inx 6412 25 University University NNP cord-010092-uftc8inx 6412 26 Hospital Hospital NNP cord-010092-uftc8inx 6412 27 2 2 CD cord-010092-uftc8inx 6412 28 Immunology Immunology NNP cord-010092-uftc8inx 6412 29 , , , cord-010092-uftc8inx 6412 30 University University NNP cord-010092-uftc8inx 6412 31 of of IN cord-010092-uftc8inx 6412 32 Oslo Oslo NNP cord-010092-uftc8inx 6412 33 , , , cord-010092-uftc8inx 6412 34 Oslo Oslo NNP cord-010092-uftc8inx 6412 35 3 3 CD cord-010092-uftc8inx 6412 36 Immunology Immunology NNP cord-010092-uftc8inx 6412 37 and and CC cord-010092-uftc8inx 6412 38 Transfusion Transfusion NNP cord-010092-uftc8inx 6412 39 Medicine Medicine NNP cord-010092-uftc8inx 6412 40 , , , cord-010092-uftc8inx 6412 41 Akershus Akershus NNP cord-010092-uftc8inx 6412 42 University University NNP cord-010092-uftc8inx 6412 43 Hospital Hospital NNP cord-010092-uftc8inx 6412 44 , , , cord-010092-uftc8inx 6412 45 Lørenskog Lørenskog NNP cord-010092-uftc8inx 6412 46 , , , cord-010092-uftc8inx 6412 47 Norway Norway NNP cord-010092-uftc8inx 6412 48 Background Background NNP cord-010092-uftc8inx 6412 49 : : : cord-010092-uftc8inx 6412 50 Allergen allergen NN cord-010092-uftc8inx 6412 51 - - HYPH cord-010092-uftc8inx 6412 52 specific specific JJ cord-010092-uftc8inx 6412 53 IgE IgE NNP cord-010092-uftc8inx 6412 54 in in IN cord-010092-uftc8inx 6412 55 donors donor NNS cord-010092-uftc8inx 6412 56 ' ' POS cord-010092-uftc8inx 6412 57 plasma plasma NN cord-010092-uftc8inx 6412 58 can can MD cord-010092-uftc8inx 6412 59 be be VB cord-010092-uftc8inx 6412 60 transferred transfer VBN cord-010092-uftc8inx 6412 61 from from IN cord-010092-uftc8inx 6412 62 blood blood NN cord-010092-uftc8inx 6412 63 donors donor NNS cord-010092-uftc8inx 6412 64 to to IN cord-010092-uftc8inx 6412 65 recipients recipient NNS cord-010092-uftc8inx 6412 66 via via IN cord-010092-uftc8inx 6412 67 plasma plasma NN cord-010092-uftc8inx 6412 68 - - HYPH cord-010092-uftc8inx 6412 69 containing contain VBG cord-010092-uftc8inx 6412 70 products product NNS cord-010092-uftc8inx 6412 71 and and CC cord-010092-uftc8inx 6412 72 consequently consequently RB cord-010092-uftc8inx 6412 73 sensitize sensitize VB cord-010092-uftc8inx 6412 74 recipient recipient NN cord-010092-uftc8inx 6412 75 's 's POS cord-010092-uftc8inx 6412 76 effector effector NN cord-010092-uftc8inx 6412 77 cells cell NNS cord-010092-uftc8inx 6412 78 bearing bear VBG cord-010092-uftc8inx 6412 79 receptors receptor NNS cord-010092-uftc8inx 6412 80 for for IN cord-010092-uftc8inx 6412 81 IgE IgE NNP cord-010092-uftc8inx 6412 82 ( ( -LRB- cord-010092-uftc8inx 6412 83 mast mast NN cord-010092-uftc8inx 6412 84 cells cell NNS cord-010092-uftc8inx 6412 85 , , , cord-010092-uftc8inx 6413 1 basophils basophil NNS cord-010092-uftc8inx 6413 2 , , , cord-010092-uftc8inx 6413 3 thrombocytes thrombocyte NNS cord-010092-uftc8inx 6413 4 etc etc FW cord-010092-uftc8inx 6413 5 . . . cord-010092-uftc8inx 6413 6 ) ) -RRB- cord-010092-uftc8inx 6413 7 . . . cord-010092-uftc8inx 6414 1 These these DT cord-010092-uftc8inx 6414 2 cells cell NNS cord-010092-uftc8inx 6414 3 can can MD cord-010092-uftc8inx 6414 4 then then RB cord-010092-uftc8inx 6414 5 degranulate degranulate VB cord-010092-uftc8inx 6414 6 after after IN cord-010092-uftc8inx 6414 7 exposure exposure NN cord-010092-uftc8inx 6414 8 to to IN cord-010092-uftc8inx 6414 9 allergen allergen NN cord-010092-uftc8inx 6414 10 . . . cord-010092-uftc8inx 6415 1 This this DT cord-010092-uftc8inx 6415 2 can can MD cord-010092-uftc8inx 6415 3 cause cause VB cord-010092-uftc8inx 6415 4 allergy allergy NN cord-010092-uftc8inx 6415 5 symptoms symptom NNS cord-010092-uftc8inx 6415 6 of of IN cord-010092-uftc8inx 6415 7 various various JJ cord-010092-uftc8inx 6415 8 degrees degree NNS cord-010092-uftc8inx 6415 9 ( ( -LRB- cord-010092-uftc8inx 6415 10 Johansson Johansson NNP cord-010092-uftc8inx 6415 11 , , , cord-010092-uftc8inx 6415 12 Allergy allergy NN cord-010092-uftc8inx 6415 13 , , , cord-010092-uftc8inx 6415 14 2005 2005 CD cord-010092-uftc8inx 6415 15 ) ) -RRB- cord-010092-uftc8inx 6415 16 . . . cord-010092-uftc8inx 6416 1 Food food NN cord-010092-uftc8inx 6416 2 allergen allergen NN cord-010092-uftc8inx 6416 3 - - HYPH cord-010092-uftc8inx 6416 4 specific specific JJ cord-010092-uftc8inx 6416 5 IgE IgE NNP cord-010092-uftc8inx 6416 6 antibodies antibody NNS cord-010092-uftc8inx 6416 7 , , , cord-010092-uftc8inx 6416 8 although although IN cord-010092-uftc8inx 6416 9 causing cause VBG cord-010092-uftc8inx 6416 10 mild mild JJ cord-010092-uftc8inx 6416 11 or or CC cord-010092-uftc8inx 6416 12 no no DT cord-010092-uftc8inx 6416 13 symptoms symptom NNS cord-010092-uftc8inx 6416 14 in in IN cord-010092-uftc8inx 6416 15 blood blood NN cord-010092-uftc8inx 6416 16 donors donor NNS cord-010092-uftc8inx 6416 17 , , , cord-010092-uftc8inx 6416 18 can can MD cord-010092-uftc8inx 6416 19 be be VB cord-010092-uftc8inx 6416 20 of of IN cord-010092-uftc8inx 6416 21 clinical clinical JJ cord-010092-uftc8inx 6416 22 importance importance NN cord-010092-uftc8inx 6416 23 to to IN cord-010092-uftc8inx 6416 24 plasma plasma NN cord-010092-uftc8inx 6416 25 recipients recipient NNS cord-010092-uftc8inx 6416 26 due due JJ cord-010092-uftc8inx 6416 27 to to IN cord-010092-uftc8inx 6416 28 varying vary VBG cord-010092-uftc8inx 6416 29 sensitization sensitization NN cord-010092-uftc8inx 6416 30 and and CC cord-010092-uftc8inx 6416 31 activation activation NN cord-010092-uftc8inx 6416 32 grade grade NN cord-010092-uftc8inx 6416 33 of of IN cord-010092-uftc8inx 6416 34 recipients recipient NNS cord-010092-uftc8inx 6416 35 ' ' POS cord-010092-uftc8inx 6416 36 effector effector NN cord-010092-uftc8inx 6416 37 cells cell NNS cord-010092-uftc8inx 6416 38 . . . cord-010092-uftc8inx 6417 1 Aims aim VBZ cord-010092-uftc8inx 6417 2 : : : cord-010092-uftc8inx 6418 1 The the DT cord-010092-uftc8inx 6418 2 aims aim NNS cord-010092-uftc8inx 6418 3 of of IN cord-010092-uftc8inx 6418 4 the the DT cord-010092-uftc8inx 6418 5 study study NN cord-010092-uftc8inx 6418 6 were be VBD cord-010092-uftc8inx 6418 7 1 1 CD cord-010092-uftc8inx 6418 8 ) ) -RRB- cord-010092-uftc8inx 6418 9 to to TO cord-010092-uftc8inx 6418 10 assess assess VB cord-010092-uftc8inx 6418 11 sensitization sensitization NN cord-010092-uftc8inx 6418 12 profiles profile NNS cord-010092-uftc8inx 6418 13 against against IN cord-010092-uftc8inx 6418 14 an an DT cord-010092-uftc8inx 6418 15 array array NN cord-010092-uftc8inx 6418 16 of of IN cord-010092-uftc8inx 6418 17 55 55 CD cord-010092-uftc8inx 6418 18 allergens allergen NNS cord-010092-uftc8inx 6418 19 in in IN cord-010092-uftc8inx 6418 20 100 100 CD cord-010092-uftc8inx 6418 21 randomly randomly RB cord-010092-uftc8inx 6418 22 selected select VBN cord-010092-uftc8inx 6418 23 blood blood NN cord-010092-uftc8inx 6418 24 donors donor NNS cord-010092-uftc8inx 6418 25 and and CC cord-010092-uftc8inx 6418 26 2 2 LS cord-010092-uftc8inx 6418 27 ) ) -RRB- cord-010092-uftc8inx 6418 28 to to TO cord-010092-uftc8inx 6418 29 identify identify VB cord-010092-uftc8inx 6418 30 donors donor NNS cord-010092-uftc8inx 6418 31 with with IN cord-010092-uftc8inx 6418 32 high high JJ cord-010092-uftc8inx 6418 33 concentrations concentration NNS cord-010092-uftc8inx 6418 34 of of IN cord-010092-uftc8inx 6418 35 food food NN cord-010092-uftc8inx 6418 36 - - HYPH cord-010092-uftc8inx 6418 37 specific specific JJ cord-010092-uftc8inx 6418 38 IgE IgE NNP cord-010092-uftc8inx 6418 39 antibodies antibody NNS cord-010092-uftc8inx 6418 40 that that WDT cord-010092-uftc8inx 6418 41 could could MD cord-010092-uftc8inx 6418 42 bear bear VB cord-010092-uftc8inx 6418 43 risk risk NN cord-010092-uftc8inx 6418 44 of of IN cord-010092-uftc8inx 6418 45 clinically clinically RB cord-010092-uftc8inx 6418 46 important important JJ cord-010092-uftc8inx 6418 47 sensitization sensitization NN cord-010092-uftc8inx 6418 48 of of IN cord-010092-uftc8inx 6418 49 plasma plasma NN cord-010092-uftc8inx 6418 50 product product NN cord-010092-uftc8inx 6418 51 recipients recipient NNS cord-010092-uftc8inx 6418 52 . . . cord-010092-uftc8inx 6419 1 Methods method NNS cord-010092-uftc8inx 6419 2 : : : cord-010092-uftc8inx 6419 3 We -PRON- PRP cord-010092-uftc8inx 6419 4 tested test VBD cord-010092-uftc8inx 6419 5 serum serum NN cord-010092-uftc8inx 6419 6 samples sample NNS cord-010092-uftc8inx 6419 7 from from IN cord-010092-uftc8inx 6419 8 100 100 CD cord-010092-uftc8inx 6419 9 blood blood NN cord-010092-uftc8inx 6419 10 donors donor NNS cord-010092-uftc8inx 6419 11 randomly randomly RB cord-010092-uftc8inx 6419 12 selected select VBN cord-010092-uftc8inx 6419 13 on on IN cord-010092-uftc8inx 6419 14 one one CD cord-010092-uftc8inx 6419 15 donation donation NN cord-010092-uftc8inx 6419 16 day day NN cord-010092-uftc8inx 6419 17 outside outside IN cord-010092-uftc8inx 6419 18 the the DT cord-010092-uftc8inx 6419 19 pollen pollen NN cord-010092-uftc8inx 6419 20 season season NN cord-010092-uftc8inx 6419 21 . . . cord-010092-uftc8inx 6420 1 We -PRON- PRP cord-010092-uftc8inx 6420 2 used use VBD cord-010092-uftc8inx 6420 3 300 300 CD cord-010092-uftc8inx 6420 4 ll will NN cord-010092-uftc8inx 6420 5 serum serum VB cord-010092-uftc8inx 6420 6 per per IN cord-010092-uftc8inx 6420 7 sample sample NN cord-010092-uftc8inx 6420 8 in in IN cord-010092-uftc8inx 6420 9 a a DT cord-010092-uftc8inx 6420 10 multiplex multiplex JJ cord-010092-uftc8inx 6420 11 IgE ige NN cord-010092-uftc8inx 6420 12 line line NN cord-010092-uftc8inx 6420 13 - - HYPH cord-010092-uftc8inx 6420 14 blot blot NN cord-010092-uftc8inx 6420 15 enzymoimmunoassay enzymoimmunoassay NN cord-010092-uftc8inx 6420 16 for for IN cord-010092-uftc8inx 6420 17 55 55 CD cord-010092-uftc8inx 6420 18 analytes analyte NNS cord-010092-uftc8inx 6420 19 ( ( -LRB- cord-010092-uftc8inx 6420 20 Euroline Euroline NNP cord-010092-uftc8inx 6420 21 Atopy Atopy NNP cord-010092-uftc8inx 6420 22 Screen Screen NNP cord-010092-uftc8inx 6420 23 , , , cord-010092-uftc8inx 6420 24 Euroimmun Euroimmun NNP cord-010092-uftc8inx 6420 25 , , , cord-010092-uftc8inx 6420 26 Germany Germany NNP cord-010092-uftc8inx 6420 27 ) ) -RRB- cord-010092-uftc8inx 6420 28 , , , cord-010092-uftc8inx 6420 29 which which WDT cord-010092-uftc8inx 6420 30 comprised comprise VBD cord-010092-uftc8inx 6420 31 28 28 CD cord-010092-uftc8inx 6420 32 food food NN cord-010092-uftc8inx 6420 33 allergen allergen NN cord-010092-uftc8inx 6420 34 extracts extract NNS cord-010092-uftc8inx 6420 35 and and CC cord-010092-uftc8inx 6420 36 single single JJ cord-010092-uftc8inx 6420 37 allergens allergen NNS cord-010092-uftc8inx 6420 38 , , , cord-010092-uftc8inx 6420 39 24 24 CD cord-010092-uftc8inx 6420 40 inhalant inhalant NN cord-010092-uftc8inx 6420 41 allergen allergen NN cord-010092-uftc8inx 6420 42 extracts extract NNS cord-010092-uftc8inx 6420 43 , , , cord-010092-uftc8inx 6420 44 2 2 CD cord-010092-uftc8inx 6420 45 insect insect NN cord-010092-uftc8inx 6420 46 venom venom NN cord-010092-uftc8inx 6420 47 extracts extract NNS cord-010092-uftc8inx 6420 48 and and CC cord-010092-uftc8inx 6420 49 one one CD cord-010092-uftc8inx 6420 50 carbohydrate carbohydrate NN cord-010092-uftc8inx 6420 51 allergen allergen NN cord-010092-uftc8inx 6420 52 CCD ccd NN cord-010092-uftc8inx 6420 53 . . . cord-010092-uftc8inx 6421 1 This this DT cord-010092-uftc8inx 6421 2 high high JJ cord-010092-uftc8inx 6421 3 - - HYPH cord-010092-uftc8inx 6421 4 throughput throughput NN cord-010092-uftc8inx 6421 5 method method NN cord-010092-uftc8inx 6421 6 enables enable VBZ cord-010092-uftc8inx 6421 7 scanning scanning NN cord-010092-uftc8inx 6421 8 of of IN cord-010092-uftc8inx 6421 9 44 44 CD cord-010092-uftc8inx 6421 10 serum serum NN cord-010092-uftc8inx 6421 11 samples sample NNS cord-010092-uftc8inx 6421 12 for for IN cord-010092-uftc8inx 6421 13 IgE IgE NNP cord-010092-uftc8inx 6421 14 against against IN cord-010092-uftc8inx 6421 15 55 55 CD cord-010092-uftc8inx 6421 16 allergens allergen NNS cord-010092-uftc8inx 6421 17 in in IN cord-010092-uftc8inx 6421 18 less less JJR cord-010092-uftc8inx 6421 19 than than IN cord-010092-uftc8inx 6421 20 3 3 CD cord-010092-uftc8inx 6421 21 h. h. NN cord-010092-uftc8inx 6421 22 Results result NNS cord-010092-uftc8inx 6421 23 are be VBP cord-010092-uftc8inx 6421 24 expressed express VBN cord-010092-uftc8inx 6421 25 as as IN cord-010092-uftc8inx 6421 26 EAST EAST NNP cord-010092-uftc8inx 6421 27 ( ( -LRB- cord-010092-uftc8inx 6421 28 enzymoimmunoassay enzymoimmunoassay NNP cord-010092-uftc8inx 6421 29 ) ) -RRB- cord-010092-uftc8inx 6421 30 classes class NNS cord-010092-uftc8inx 6421 31 : : : cord-010092-uftc8inx 6421 32 class class NN cord-010092-uftc8inx 6421 33 0 0 CD cord-010092-uftc8inx 6421 34 ( ( -LRB- cord-010092-uftc8inx 6421 35 no no DT cord-010092-uftc8inx 6421 36 sensitization sensitization NN cord-010092-uftc8inx 6421 37 ) ) -RRB- cord-010092-uftc8inx 6421 38 , , , cord-010092-uftc8inx 6421 39 1 1 CD cord-010092-uftc8inx 6421 40 - - SYM cord-010092-uftc8inx 6421 41 2 2 CD cord-010092-uftc8inx 6421 42 ( ( -LRB- cord-010092-uftc8inx 6421 43 weak weak JJ cord-010092-uftc8inx 6421 44 sensitization sensitization NN cord-010092-uftc8inx 6421 45 ) ) -RRB- cord-010092-uftc8inx 6421 46 , , , cord-010092-uftc8inx 6421 47 3 3 LS cord-010092-uftc8inx 6421 48 ( ( -LRB- cord-010092-uftc8inx 6421 49 moderate moderate JJ cord-010092-uftc8inx 6421 50 sensitization sensitization NN cord-010092-uftc8inx 6421 51 ) ) -RRB- cord-010092-uftc8inx 6421 52 , , , cord-010092-uftc8inx 6421 53 4 4 CD cord-010092-uftc8inx 6421 54 - - SYM cord-010092-uftc8inx 6421 55 5 5 CD cord-010092-uftc8inx 6421 56 ( ( -LRB- cord-010092-uftc8inx 6421 57 strong strong JJ cord-010092-uftc8inx 6421 58 and and CC cord-010092-uftc8inx 6421 59 very very RB cord-010092-uftc8inx 6421 60 strong strong JJ cord-010092-uftc8inx 6421 61 sensitization sensitization NN cord-010092-uftc8inx 6421 62 ) ) -RRB- cord-010092-uftc8inx 6421 63 . . . cord-010092-uftc8inx 6422 1 Results result NNS cord-010092-uftc8inx 6422 2 : : : cord-010092-uftc8inx 6423 1 EAST EAST NNP cord-010092-uftc8inx 6423 2 class class NN cord-010092-uftc8inx 6423 3 , , , cord-010092-uftc8inx 6423 4 allergen allergen NN cord-010092-uftc8inx 6423 5 , , , cord-010092-uftc8inx 6423 6 number number NN cord-010092-uftc8inx 6423 7 of of IN cord-010092-uftc8inx 6423 8 samples sample NNS cord-010092-uftc8inx 6423 9 . . . cord-010092-uftc8inx 6424 1 Food food NN cord-010092-uftc8inx 6424 2 allergens allergen NNS cord-010092-uftc8inx 6424 3 : : : cord-010092-uftc8inx 6424 4 class class NN cord-010092-uftc8inx 6424 5 5none 5none CD cord-010092-uftc8inx 6424 6 detected detect VBD cord-010092-uftc8inx 6424 7 . . . cord-010092-uftc8inx 6425 1 Class class NN cord-010092-uftc8inx 6425 2 4 4 CD cord-010092-uftc8inx 6425 3 , , , cord-010092-uftc8inx 6425 4 sesame sesame NN cord-010092-uftc8inx 6425 5 seed seed NN cord-010092-uftc8inx 6425 6 : : : cord-010092-uftc8inx 6425 7 1 1 CD cord-010092-uftc8inx 6425 8 . . . cord-010092-uftc8inx 6426 1 Class class NN cord-010092-uftc8inx 6426 2 3 3 CD cord-010092-uftc8inx 6426 3 , , , cord-010092-uftc8inx 6426 4 apple apple NNP cord-010092-uftc8inx 6426 5 1 1 CD cord-010092-uftc8inx 6426 6 ; ; : cord-010092-uftc8inx 6426 7 hazelnut hazelnut NNP cord-010092-uftc8inx 6426 8 2 2 CD cord-010092-uftc8inx 6426 9 . . . cord-010092-uftc8inx 6427 1 Class class NN cord-010092-uftc8inx 6427 2 2 2 CD cord-010092-uftc8inx 6427 3 , , , cord-010092-uftc8inx 6427 4 apple apple NNP cord-010092-uftc8inx 6427 5 1 1 CD cord-010092-uftc8inx 6427 6 ; ; : cord-010092-uftc8inx 6427 7 almond almond NNP cord-010092-uftc8inx 6427 8 2 2 CD cord-010092-uftc8inx 6427 9 ; ; : cord-010092-uftc8inx 6427 10 hazelnut hazelnut NNP cord-010092-uftc8inx 6427 11 1 1 CD cord-010092-uftc8inx 6427 12 ; ; : cord-010092-uftc8inx 6427 13 sesame sesame NNP cord-010092-uftc8inx 6427 14 seed seed NN cord-010092-uftc8inx 6427 15 1 1 CD cord-010092-uftc8inx 6427 16 ; ; : cord-010092-uftc8inx 6427 17 soybean soybean NN cord-010092-uftc8inx 6427 18 1 1 CD cord-010092-uftc8inx 6427 19 ; ; : cord-010092-uftc8inx 6427 20 cow cow NN cord-010092-uftc8inx 6427 21 milk milk NN cord-010092-uftc8inx 6427 22 alpha alpha NN cord-010092-uftc8inx 6427 23 - - HYPH cord-010092-uftc8inx 6427 24 lactalbumin lactalbumin JJ cord-010092-uftc8inx 6427 25 3 3 CD cord-010092-uftc8inx 6427 26 . . . cord-010092-uftc8inx 6428 1 Class class NN cord-010092-uftc8inx 6428 2 1 1 CD cord-010092-uftc8inx 6428 3 : : : cord-010092-uftc8inx 6429 1 26 26 CD cord-010092-uftc8inx 6429 2 donors donor NNS cord-010092-uftc8inx 6429 3 weakly weakly RB cord-010092-uftc8inx 6429 4 sensitized sensitize VBN cord-010092-uftc8inx 6429 5 to to IN cord-010092-uftc8inx 6429 6 one one CD cord-010092-uftc8inx 6429 7 or or CC cord-010092-uftc8inx 6429 8 more more JJR cord-010092-uftc8inx 6429 9 allergens allergen NNS cord-010092-uftc8inx 6429 10 as as IN cord-010092-uftc8inx 6429 11 kiwi kiwi NN cord-010092-uftc8inx 6429 12 , , , cord-010092-uftc8inx 6429 13 apple apple NNP cord-010092-uftc8inx 6429 14 , , , cord-010092-uftc8inx 6429 15 almond almond NN cord-010092-uftc8inx 6429 16 , , , cord-010092-uftc8inx 6429 17 hazelnut hazelnut NN cord-010092-uftc8inx 6429 18 , , , cord-010092-uftc8inx 6429 19 sesame sesame NN cord-010092-uftc8inx 6429 20 , , , cord-010092-uftc8inx 6429 21 soybean soybean NN cord-010092-uftc8inx 6429 22 , , , cord-010092-uftc8inx 6429 23 wheat wheat NN cord-010092-uftc8inx 6429 24 , , , cord-010092-uftc8inx 6429 25 mutton mutton NN cord-010092-uftc8inx 6429 26 , , , cord-010092-uftc8inx 6429 27 beef beef NN cord-010092-uftc8inx 6429 28 , , , cord-010092-uftc8inx 6429 29 cow cow NN cord-010092-uftc8inx 6429 30 milk milk NN cord-010092-uftc8inx 6429 31 beta beta NN cord-010092-uftc8inx 6429 32 - - : cord-010092-uftc8inx 6429 33 lactoglobulin lactoglobulin NN cord-010092-uftc8inx 6429 34 and and CC cord-010092-uftc8inx 6429 35 alpha alpha NN cord-010092-uftc8inx 6429 36 - - HYPH cord-010092-uftc8inx 6429 37 lactalbumin lactalbumin JJ cord-010092-uftc8inx 6429 38 . . . cord-010092-uftc8inx 6430 1 We -PRON- PRP cord-010092-uftc8inx 6430 2 did do VBD cord-010092-uftc8inx 6430 3 not not RB cord-010092-uftc8inx 6430 4 find find VB cord-010092-uftc8inx 6430 5 any any DT cord-010092-uftc8inx 6430 6 donors donor NNS cord-010092-uftc8inx 6430 7 sensitized sensitize VBN cord-010092-uftc8inx 6430 8 to to IN cord-010092-uftc8inx 6430 9 apricot apricot NN cord-010092-uftc8inx 6430 10 , , , cord-010092-uftc8inx 6430 11 peanut peanut NN cord-010092-uftc8inx 6430 12 , , , cord-010092-uftc8inx 6430 13 rice rice NN cord-010092-uftc8inx 6430 14 , , , cord-010092-uftc8inx 6430 15 rye rye NN cord-010092-uftc8inx 6430 16 , , , cord-010092-uftc8inx 6430 17 yeast yeast NN cord-010092-uftc8inx 6430 18 , , , cord-010092-uftc8inx 6430 19 cow cow NN cord-010092-uftc8inx 6430 20 milk milk NN cord-010092-uftc8inx 6430 21 casein casein NN cord-010092-uftc8inx 6430 22 and and CC cord-010092-uftc8inx 6430 23 carbohydrate carbohydrate NN cord-010092-uftc8inx 6430 24 allergen allergen NN cord-010092-uftc8inx 6430 25 CCD ccd NN cord-010092-uftc8inx 6430 26 . . . cord-010092-uftc8inx 6431 1 Insect insect NN cord-010092-uftc8inx 6431 2 venoms venom NNS cord-010092-uftc8inx 6431 3 : : : cord-010092-uftc8inx 6431 4 Class class NN cord-010092-uftc8inx 6431 5 5 5 CD cord-010092-uftc8inx 6431 6 , , , cord-010092-uftc8inx 6431 7 4 4 CD cord-010092-uftc8inx 6431 8 and and CC cord-010092-uftc8inx 6431 9 3 3 CD cord-010092-uftc8inx 6431 10 none none NN cord-010092-uftc8inx 6431 11 , , , cord-010092-uftc8inx 6431 12 class class NN cord-010092-uftc8inx 6431 13 2 2 CD cord-010092-uftc8inx 6431 14 , , , cord-010092-uftc8inx 6431 15 wasp wasp NN cord-010092-uftc8inx 6431 16 venom venom NN cord-010092-uftc8inx 6431 17 7 7 CD cord-010092-uftc8inx 6431 18 ; ; : cord-010092-uftc8inx 6431 19 honey honey NN cord-010092-uftc8inx 6431 20 bee bee NN cord-010092-uftc8inx 6431 21 2 2 CD cord-010092-uftc8inx 6431 22 . . . cord-010092-uftc8inx 6432 1 Lower low JJR cord-010092-uftc8inx 6432 2 classes class NNS cord-010092-uftc8inx 6432 3 ( ( -LRB- cord-010092-uftc8inx 6432 4 0 0 CD cord-010092-uftc8inx 6432 5 - - SYM cord-010092-uftc8inx 6432 6 1 1 CD cord-010092-uftc8inx 6432 7 ) ) -RRB- cord-010092-uftc8inx 6432 8 not not RB cord-010092-uftc8inx 6432 9 reported report VBN cord-010092-uftc8inx 6432 10 in in IN cord-010092-uftc8inx 6432 11 this this DT cord-010092-uftc8inx 6432 12 abstract abstract NN cord-010092-uftc8inx 6432 13 . . . cord-010092-uftc8inx 6433 1 Summary Summary NNP cord-010092-uftc8inx 6433 2 / / SYM cord-010092-uftc8inx 6433 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 6433 4 : : : cord-010092-uftc8inx 6434 1 We -PRON- PRP cord-010092-uftc8inx 6434 2 found find VBD cord-010092-uftc8inx 6434 3 considerable considerable JJ cord-010092-uftc8inx 6434 4 sensitization sensitization NN cord-010092-uftc8inx 6434 5 to to IN cord-010092-uftc8inx 6434 6 inhalant inhalant JJ cord-010092-uftc8inx 6434 7 allergens allergen NNS cord-010092-uftc8inx 6434 8 but but CC cord-010092-uftc8inx 6434 9 such such JJ cord-010092-uftc8inx 6434 10 sensitization sensitization NN cord-010092-uftc8inx 6434 11 probably probably RB cord-010092-uftc8inx 6434 12 represents represent VBZ cord-010092-uftc8inx 6434 13 low low JJ cord-010092-uftc8inx 6434 14 risk risk NN cord-010092-uftc8inx 6434 15 of of IN cord-010092-uftc8inx 6434 16 clinical clinical JJ cord-010092-uftc8inx 6434 17 allergies allergy NNS cord-010092-uftc8inx 6434 18 due due JJ cord-010092-uftc8inx 6434 19 to to IN cord-010092-uftc8inx 6434 20 passive passive JJ cord-010092-uftc8inx 6434 21 transfer transfer NN cord-010092-uftc8inx 6434 22 of of IN cord-010092-uftc8inx 6434 23 antibodies antibody NNS cord-010092-uftc8inx 6434 24 . . . cord-010092-uftc8inx 6435 1 Sensitization sensitization NN cord-010092-uftc8inx 6435 2 to to TO cord-010092-uftc8inx 6435 3 insect insect NN cord-010092-uftc8inx 6435 4 venoms venom NNS cord-010092-uftc8inx 6435 5 was be VBD cord-010092-uftc8inx 6435 6 negligible negligible JJ cord-010092-uftc8inx 6435 7 . . . cord-010092-uftc8inx 6436 1 We -PRON- PRP cord-010092-uftc8inx 6436 2 disclosed disclose VBD cord-010092-uftc8inx 6436 3 only only RB cord-010092-uftc8inx 6436 4 one one CD cord-010092-uftc8inx 6436 5 blood blood NN cord-010092-uftc8inx 6436 6 donor donor NN cord-010092-uftc8inx 6436 7 ( ( -LRB- cord-010092-uftc8inx 6436 8 1 1 CD cord-010092-uftc8inx 6436 9 % % NN cord-010092-uftc8inx 6436 10 ) ) -RRB- cord-010092-uftc8inx 6436 11 with with IN cord-010092-uftc8inx 6436 12 high high JJ cord-010092-uftc8inx 6436 13 IgE IgE NNP cord-010092-uftc8inx 6436 14 to to IN cord-010092-uftc8inx 6436 15 sesame sesame NNP cord-010092-uftc8inx 6436 16 seed seed NN cord-010092-uftc8inx 6436 17 with with IN cord-010092-uftc8inx 6436 18 a a DT cord-010092-uftc8inx 6436 19 potential potential NN cord-010092-uftc8inx 6436 20 to to TO cord-010092-uftc8inx 6436 21 transfer transfer VB cord-010092-uftc8inx 6436 22 clinically clinically RB cord-010092-uftc8inx 6436 23 relevant relevant JJ cord-010092-uftc8inx 6436 24 IgE IgE NNP cord-010092-uftc8inx 6436 25 antibodies antibody NNS cord-010092-uftc8inx 6436 26 via via IN cord-010092-uftc8inx 6436 27 plasma plasma NN cord-010092-uftc8inx 6436 28 products product NNS cord-010092-uftc8inx 6436 29 . . . cord-010092-uftc8inx 6437 1 The the DT cord-010092-uftc8inx 6437 2 need need NN cord-010092-uftc8inx 6437 3 for for IN cord-010092-uftc8inx 6437 4 a a DT cord-010092-uftc8inx 6437 5 broad broad JJ cord-010092-uftc8inx 6437 6 screening screening NN cord-010092-uftc8inx 6437 7 of of IN cord-010092-uftc8inx 6437 8 donors donor NNS cord-010092-uftc8inx 6437 9 for for IN cord-010092-uftc8inx 6437 10 IgE IgE NNP cord-010092-uftc8inx 6437 11 sensitization sensitization NN cord-010092-uftc8inx 6437 12 remains remain VBZ cord-010092-uftc8inx 6437 13 still still RB cord-010092-uftc8inx 6437 14 questionable questionable JJ cord-010092-uftc8inx 6437 15 . . . cord-010092-uftc8inx 6438 1 Background background NN cord-010092-uftc8inx 6438 2 : : : cord-010092-uftc8inx 6439 1 The the DT cord-010092-uftc8inx 6439 2 platelet platelet NN cord-010092-uftc8inx 6439 3 storage storage NN cord-010092-uftc8inx 6439 4 lesion lesion NN cord-010092-uftc8inx 6439 5 ( ( -LRB- cord-010092-uftc8inx 6439 6 PSL PSL NNP cord-010092-uftc8inx 6439 7 ) ) -RRB- cord-010092-uftc8inx 6439 8 is be VBZ cord-010092-uftc8inx 6439 9 one one CD cord-010092-uftc8inx 6439 10 of of IN cord-010092-uftc8inx 6439 11 the the DT cord-010092-uftc8inx 6439 12 key key JJ cord-010092-uftc8inx 6439 13 factors factor NNS cord-010092-uftc8inx 6439 14 that that WDT cord-010092-uftc8inx 6439 15 limit limit VBP cord-010092-uftc8inx 6439 16 the the DT cord-010092-uftc8inx 6439 17 platelet platelet NN cord-010092-uftc8inx 6439 18 shelf shelf NN cord-010092-uftc8inx 6439 19 - - HYPH cord-010092-uftc8inx 6439 20 life life NN cord-010092-uftc8inx 6439 21 to to IN cord-010092-uftc8inx 6439 22 5 5 CD cord-010092-uftc8inx 6439 23 days day NNS cord-010092-uftc8inx 6439 24 . . . cord-010092-uftc8inx 6440 1 The the DT cord-010092-uftc8inx 6440 2 mechanisms mechanism NNS cord-010092-uftc8inx 6440 3 mediating mediate VBG cord-010092-uftc8inx 6440 4 the the DT cord-010092-uftc8inx 6440 5 PSL PSL NNP cord-010092-uftc8inx 6440 6 are be VBP cord-010092-uftc8inx 6440 7 not not RB cord-010092-uftc8inx 6440 8 well well RB cord-010092-uftc8inx 6440 9 understood understand VBN cord-010092-uftc8inx 6440 10 , , , cord-010092-uftc8inx 6440 11 but but CC cord-010092-uftc8inx 6440 12 it -PRON- PRP cord-010092-uftc8inx 6440 13 is be VBZ cord-010092-uftc8inx 6440 14 becoming become VBG cord-010092-uftc8inx 6440 15 increasingly increasingly RB cord-010092-uftc8inx 6440 16 evident evident JJ cord-010092-uftc8inx 6440 17 that that IN cord-010092-uftc8inx 6440 18 platelets platelet NNS cord-010092-uftc8inx 6440 19 from from IN cord-010092-uftc8inx 6440 20 some some DT cord-010092-uftc8inx 6440 21 donors donor NNS cord-010092-uftc8inx 6440 22 do do VBP cord-010092-uftc8inx 6440 23 not not RB cord-010092-uftc8inx 6440 24 store store VB cord-010092-uftc8inx 6440 25 as as RB cord-010092-uftc8inx 6440 26 well well RB cord-010092-uftc8inx 6440 27 as as IN cord-010092-uftc8inx 6440 28 others other NNS cord-010092-uftc8inx 6440 29 . . . cord-010092-uftc8inx 6441 1 Similarly similarly RB cord-010092-uftc8inx 6441 2 , , , cord-010092-uftc8inx 6441 3 assessment assessment NN cord-010092-uftc8inx 6441 4 of of IN cord-010092-uftc8inx 6441 5 many many JJ cord-010092-uftc8inx 6441 6 in in IN cord-010092-uftc8inx 6441 7 vitro vitro FW cord-010092-uftc8inx 6441 8 quality quality NN cord-010092-uftc8inx 6441 9 parameters parameter NNS cord-010092-uftc8inx 6441 10 has have VBZ cord-010092-uftc8inx 6441 11 been be VBN cord-010092-uftc8inx 6441 12 used use VBN cord-010092-uftc8inx 6441 13 to to TO cord-010092-uftc8inx 6441 14 predict predict VB cord-010092-uftc8inx 6441 15 transfusion transfusion NN cord-010092-uftc8inx 6441 16 outcomes outcome NNS cord-010092-uftc8inx 6441 17 , , , cord-010092-uftc8inx 6441 18 with with IN cord-010092-uftc8inx 6441 19 varying vary VBG cord-010092-uftc8inx 6441 20 degrees degree NNS cord-010092-uftc8inx 6441 21 of of IN cord-010092-uftc8inx 6441 22 success success NN cord-010092-uftc8inx 6441 23 . . . cord-010092-uftc8inx 6442 1 Donor donor NN cord-010092-uftc8inx 6442 2 attributes attribute NNS cord-010092-uftc8inx 6442 3 such such JJ cord-010092-uftc8inx 6442 4 as as IN cord-010092-uftc8inx 6442 5 age age NN cord-010092-uftc8inx 6442 6 , , , cord-010092-uftc8inx 6442 7 and and CC cord-010092-uftc8inx 6442 8 body body NN cord-010092-uftc8inx 6442 9 mass mass NN cord-010092-uftc8inx 6442 10 index index NN cord-010092-uftc8inx 6442 11 ( ( -LRB- cord-010092-uftc8inx 6442 12 BMI BMI NNP cord-010092-uftc8inx 6442 13 ) ) -RRB- cord-010092-uftc8inx 6442 14 may may MD cord-010092-uftc8inx 6442 15 contribute contribute VB cord-010092-uftc8inx 6442 16 to to IN cord-010092-uftc8inx 6442 17 these these DT cord-010092-uftc8inx 6442 18 differences difference NNS cord-010092-uftc8inx 6442 19 . . . cord-010092-uftc8inx 6443 1 Aims aim VBZ cord-010092-uftc8inx 6443 2 : : : cord-010092-uftc8inx 6443 3 To to TO cord-010092-uftc8inx 6443 4 characterise characterise VB cord-010092-uftc8inx 6443 5 the the DT cord-010092-uftc8inx 6443 6 variability variability NN cord-010092-uftc8inx 6443 7 in in IN cord-010092-uftc8inx 6443 8 the the DT cord-010092-uftc8inx 6443 9 quality quality NN cord-010092-uftc8inx 6443 10 and and CC cord-010092-uftc8inx 6443 11 function function NN cord-010092-uftc8inx 6443 12 of of IN cord-010092-uftc8inx 6443 13 apheresis apheresis NN cord-010092-uftc8inx 6443 14 platelet platelet NN cord-010092-uftc8inx 6443 15 donations donation NNS cord-010092-uftc8inx 6443 16 and and CC cord-010092-uftc8inx 6443 17 to to TO cord-010092-uftc8inx 6443 18 examine examine VB cord-010092-uftc8inx 6443 19 associations association NNS cord-010092-uftc8inx 6443 20 between between IN cord-010092-uftc8inx 6443 21 donor donor NN cord-010092-uftc8inx 6443 22 attributes attribute NNS cord-010092-uftc8inx 6443 23 and and CC cord-010092-uftc8inx 6443 24 platelet platelet NN cord-010092-uftc8inx 6443 25 characteristics characteristic NNS cord-010092-uftc8inx 6443 26 . . . cord-010092-uftc8inx 6444 1 Methods method NNS cord-010092-uftc8inx 6444 2 : : : cord-010092-uftc8inx 6444 3 Apheresis Apheresis NNP cord-010092-uftc8inx 6444 4 platelets platelet NNS cord-010092-uftc8inx 6444 5 ( ( -LRB- cord-010092-uftc8inx 6444 6 n n NN cord-010092-uftc8inx 6444 7 = = SYM cord-010092-uftc8inx 6444 8 53 53 CD cord-010092-uftc8inx 6444 9 ) ) -RRB- cord-010092-uftc8inx 6444 10 were be VBD cord-010092-uftc8inx 6444 11 collected collect VBN cord-010092-uftc8inx 6444 12 , , , cord-010092-uftc8inx 6444 13 stored store VBN cord-010092-uftc8inx 6444 14 at at IN cord-010092-uftc8inx 6444 15 22 22 CD cord-010092-uftc8inx 6444 16 ° ° NN cord-010092-uftc8inx 6444 17 C c NN cord-010092-uftc8inx 6444 18 with with IN cord-010092-uftc8inx 6444 19 agitation agitation NN cord-010092-uftc8inx 6444 20 , , , cord-010092-uftc8inx 6444 21 and and CC cord-010092-uftc8inx 6444 22 tested test VBN cord-010092-uftc8inx 6444 23 at at IN cord-010092-uftc8inx 6444 24 day day NN cord-010092-uftc8inx 6444 25 1 1 CD cord-010092-uftc8inx 6444 26 , , , cord-010092-uftc8inx 6444 27 day day NN cord-010092-uftc8inx 6444 28 5 5 CD cord-010092-uftc8inx 6444 29 and and CC cord-010092-uftc8inx 6444 30 7 7 CD cord-010092-uftc8inx 6444 31 post post NN cord-010092-uftc8inx 6444 32 - - NN cord-010092-uftc8inx 6444 33 collection collection NN cord-010092-uftc8inx 6444 34 . . . cord-010092-uftc8inx 6445 1 VWF VWF NNP cord-010092-uftc8inx 6445 2 and and CC cord-010092-uftc8inx 6445 3 fibrinogen fibrinogen NN cord-010092-uftc8inx 6445 4 binding bind VBG cord-010092-uftc8inx 6445 5 ( ( -LRB- cord-010092-uftc8inx 6445 6 indicators indicator NNS cord-010092-uftc8inx 6445 7 of of IN cord-010092-uftc8inx 6445 8 platelet platelet NN cord-010092-uftc8inx 6445 9 adhesion adhesion NN cord-010092-uftc8inx 6445 10 ; ; : cord-010092-uftc8inx 6445 11 AE AE NNP cord-010092-uftc8inx 6445 12 ristocetin ristocetin JJ cord-010092-uftc8inx 6445 13 stimulation stimulation NN cord-010092-uftc8inx 6445 14 ) ) -RRB- cord-010092-uftc8inx 6445 15 , , , cord-010092-uftc8inx 6445 16 phosphatidylserine phosphatidylserine NN cord-010092-uftc8inx 6445 17 ( ( -LRB- cord-010092-uftc8inx 6445 18 PS PS NNP cord-010092-uftc8inx 6445 19 ) ) -RRB- cord-010092-uftc8inx 6445 20 exposure exposure NN cord-010092-uftc8inx 6445 21 ( ( -LRB- cord-010092-uftc8inx 6445 22 annexin annexin NNP cord-010092-uftc8inx 6445 23 V V NNP cord-010092-uftc8inx 6445 24 binding binding NN cord-010092-uftc8inx 6445 25 ) ) -RRB- cord-010092-uftc8inx 6445 26 and and CC cord-010092-uftc8inx 6445 27 microparticles microparticle NNS cord-010092-uftc8inx 6445 28 ( ( -LRB- cord-010092-uftc8inx 6445 29 CD61 CD61 NNP cord-010092-uftc8inx 6445 30 + + CC cord-010092-uftc8inx 6445 31 /annexin /annexin . cord-010092-uftc8inx 6445 32 - - HYPH cord-010092-uftc8inx 6445 33 V v NN cord-010092-uftc8inx 6445 34 + + NN cord-010092-uftc8inx 6445 35 ) ) -RRB- cord-010092-uftc8inx 6445 36 were be VBD cord-010092-uftc8inx 6445 37 measured measure VBN cord-010092-uftc8inx 6445 38 by by IN cord-010092-uftc8inx 6445 39 flow flow NN cord-010092-uftc8inx 6445 40 cytometry cytometry NN cord-010092-uftc8inx 6445 41 . . . cord-010092-uftc8inx 6446 1 Platelet platelet NN cord-010092-uftc8inx 6446 2 aggregation aggregation NN cord-010092-uftc8inx 6446 3 was be VBD cord-010092-uftc8inx 6446 4 initiated initiate VBN cord-010092-uftc8inx 6446 5 with with IN cord-010092-uftc8inx 6446 6 collagen collagen NN cord-010092-uftc8inx 6446 7 , , , cord-010092-uftc8inx 6446 8 thrombin thrombin NN cord-010092-uftc8inx 6446 9 or or CC cord-010092-uftc8inx 6446 10 arachidonic arachidonic JJ cord-010092-uftc8inx 6446 11 acid acid NN cord-010092-uftc8inx 6446 12 . . . cord-010092-uftc8inx 6447 1 Thromboxane Thromboxane NNP cord-010092-uftc8inx 6447 2 A a DT cord-010092-uftc8inx 6447 3 2 2 CD cord-010092-uftc8inx 6447 4 ( ( -LRB- cord-010092-uftc8inx 6447 5 TxA TxA NNP cord-010092-uftc8inx 6447 6 2 2 CD cord-010092-uftc8inx 6447 7 ) ) -RRB- cord-010092-uftc8inx 6447 8 was be VBD cord-010092-uftc8inx 6447 9 measured measure VBN cord-010092-uftc8inx 6447 10 by by IN cord-010092-uftc8inx 6447 11 ELISA ELISA NNP cord-010092-uftc8inx 6447 12 . . . cord-010092-uftc8inx 6448 1 The the DT cord-010092-uftc8inx 6448 2 proportion proportion NN cord-010092-uftc8inx 6448 3 of of IN cord-010092-uftc8inx 6448 4 procoagulant procoagulant NN cord-010092-uftc8inx 6448 5 platelets platelet NNS cord-010092-uftc8inx 6448 6 ( ( -LRB- cord-010092-uftc8inx 6448 7 % % NN cord-010092-uftc8inx 6448 8 COATED COATED NNP cord-010092-uftc8inx 6448 9 platelets platelet NNS cord-010092-uftc8inx 6448 10 ) ) -RRB- cord-010092-uftc8inx 6448 11 was be VBD cord-010092-uftc8inx 6448 12 assessed assess VBN cord-010092-uftc8inx 6448 13 by by IN cord-010092-uftc8inx 6448 14 fibrinogen fibrinogen NN cord-010092-uftc8inx 6448 15 binding binding NN cord-010092-uftc8inx 6448 16 following follow VBG cord-010092-uftc8inx 6449 1 collagen collagen NN cord-010092-uftc8inx 6449 2 / / SYM cord-010092-uftc8inx 6449 3 thrombin thrombin JJ cord-010092-uftc8inx 6449 4 stimulation stimulation NN cord-010092-uftc8inx 6449 5 . . . cord-010092-uftc8inx 6450 1 Platelet platelet NN cord-010092-uftc8inx 6450 2 - - HYPH cord-010092-uftc8inx 6450 3 attached attach VBN cord-010092-uftc8inx 6450 4 glycans glycan NNS cord-010092-uftc8inx 6450 5 were be VBD cord-010092-uftc8inx 6450 6 measured measure VBN cord-010092-uftc8inx 6450 7 using use VBG cord-010092-uftc8inx 6450 8 flow flow NN cord-010092-uftc8inx 6450 9 cytometry cytometry NN cord-010092-uftc8inx 6450 10 and and CC cord-010092-uftc8inx 6450 11 lectins lectin NNS cord-010092-uftc8inx 6450 12 Ricinus Ricinus NNP cord-010092-uftc8inx 6450 13 Communis Communis NNP cord-010092-uftc8inx 6451 1 Agglutinin-1 Agglutinin-1 NNP cord-010092-uftc8inx 6452 1 ( ( -LRB- cord-010092-uftc8inx 6452 2 RCA-1 rca-1 RB cord-010092-uftc8inx 6452 3 ; ; : cord-010092-uftc8inx 6452 4 detecting detect VBG cord-010092-uftc8inx 6452 5 galactose galactose NN cord-010092-uftc8inx 6452 6 - - HYPH cord-010092-uftc8inx 6452 7 residues residue NNS cord-010092-uftc8inx 6452 8 ) ) -RRB- cord-010092-uftc8inx 6452 9 and and CC cord-010092-uftc8inx 6452 10 Wheat Wheat NNP cord-010092-uftc8inx 6452 11 Germ Germ NNP cord-010092-uftc8inx 6452 12 Agglutinin Agglutinin NNP cord-010092-uftc8inx 6452 13 ( ( -LRB- cord-010092-uftc8inx 6452 14 WGA WGA NNP cord-010092-uftc8inx 6452 15 ; ; : cord-010092-uftc8inx 6452 16 detecting detect VBG cord-010092-uftc8inx 6452 17 sialic sialic JJ cord-010092-uftc8inx 6452 18 acid acid NN cord-010092-uftc8inx 6452 19 and and CC cord-010092-uftc8inx 6452 20 Nacetyl Nacetyl NNP cord-010092-uftc8inx 6452 21 - - HYPH cord-010092-uftc8inx 6452 22 D D NNP cord-010092-uftc8inx 6452 23 - - HYPH cord-010092-uftc8inx 6452 24 glucosamine glucosamine NN cord-010092-uftc8inx 6452 25 , , , cord-010092-uftc8inx 6452 26 GlcNAc glcnac NN cord-010092-uftc8inx 6452 27 - - HYPH cord-010092-uftc8inx 6452 28 residues residue NNS cord-010092-uftc8inx 6452 29 ) ) -RRB- cord-010092-uftc8inx 6453 1 AE AE NNP cord-010092-uftc8inx 6453 2 stimulation stimulation NN cord-010092-uftc8inx 6453 3 with with IN cord-010092-uftc8inx 6453 4 ristocetin ristocetin NNP cord-010092-uftc8inx 6453 5 . . . cord-010092-uftc8inx 6454 1 Donation donation NN cord-010092-uftc8inx 6454 2 time time NN cord-010092-uftc8inx 6454 3 , , , cord-010092-uftc8inx 6454 4 donor donor NN cord-010092-uftc8inx 6454 5 age age NN cord-010092-uftc8inx 6454 6 , , , cord-010092-uftc8inx 6454 7 blood blood NN cord-010092-uftc8inx 6454 8 pressure pressure NN cord-010092-uftc8inx 6454 9 ( ( -LRB- cord-010092-uftc8inx 6454 10 BP BP NNP cord-010092-uftc8inx 6454 11 ) ) -RRB- cord-010092-uftc8inx 6454 12 and and CC cord-010092-uftc8inx 6454 13 BMI BMI NNP cord-010092-uftc8inx 6454 14 were be VBD cord-010092-uftc8inx 6454 15 recorded record VBN cord-010092-uftc8inx 6454 16 . . . cord-010092-uftc8inx 6455 1 Linear linear JJ cord-010092-uftc8inx 6455 2 regression regression NN cord-010092-uftc8inx 6455 3 was be VBD cord-010092-uftc8inx 6455 4 performed perform VBN cord-010092-uftc8inx 6455 5 using use VBG cord-010092-uftc8inx 6455 6 GraphPad GraphPad NNP cord-010092-uftc8inx 6455 7 Prism Prism NNP cord-010092-uftc8inx 6455 8 software software NN cord-010092-uftc8inx 6455 9 . . . cord-010092-uftc8inx 6456 1 Results result NNS cord-010092-uftc8inx 6456 2 : : : cord-010092-uftc8inx 6457 1 For for IN cord-010092-uftc8inx 6457 2 many many JJ cord-010092-uftc8inx 6457 3 of of IN cord-010092-uftc8inx 6457 4 the the DT cord-010092-uftc8inx 6457 5 parameters parameter NNS cord-010092-uftc8inx 6457 6 measured measure VBN cord-010092-uftc8inx 6457 7 , , , cord-010092-uftc8inx 6457 8 there there EX cord-010092-uftc8inx 6457 9 was be VBD cord-010092-uftc8inx 6457 10 high high JJ cord-010092-uftc8inx 6457 11 inter inter JJ cord-010092-uftc8inx 6457 12 - - JJ cord-010092-uftc8inx 6457 13 donor donor JJ cord-010092-uftc8inx 6457 14 variability variability NN cord-010092-uftc8inx 6457 15 . . . cord-010092-uftc8inx 6458 1 Platelets platelet NNS cord-010092-uftc8inx 6458 2 from from IN cord-010092-uftc8inx 6458 3 subsets subset NNS cord-010092-uftc8inx 6458 4 of of IN cord-010092-uftc8inx 6458 5 donors donor NNS cord-010092-uftc8inx 6458 6 showed show VBD cord-010092-uftc8inx 6458 7 up up RP cord-010092-uftc8inx 6458 8 to to TO cord-010092-uftc8inx 6458 9 4-fold 4-fold CD cord-010092-uftc8inx 6458 10 higher high JJR cord-010092-uftc8inx 6458 11 VWF vwf NN cord-010092-uftc8inx 6458 12 and and CC cord-010092-uftc8inx 6458 13 fibrinogen fibrinogen NN cord-010092-uftc8inx 6458 14 binding binding NN cord-010092-uftc8inx 6458 15 , , , cord-010092-uftc8inx 6458 16 formation formation NN cord-010092-uftc8inx 6458 17 of of IN cord-010092-uftc8inx 6458 18 COATED coated JJ cord-010092-uftc8inx 6458 19 platelets platelet NNS cord-010092-uftc8inx 6458 20 and and CC cord-010092-uftc8inx 6458 21 microparticle microparticle NNP cord-010092-uftc8inx 6458 22 numbers number NNS cord-010092-uftc8inx 6458 23 . . . cord-010092-uftc8inx 6459 1 Binding bind VBG cord-010092-uftc8inx 6459 2 of of IN cord-010092-uftc8inx 6459 3 lectins lectin NNS cord-010092-uftc8inx 6459 4 was be VBD cord-010092-uftc8inx 6459 5 also also RB cord-010092-uftc8inx 6459 6 highly highly RB cord-010092-uftc8inx 6459 7 variable variable JJ cord-010092-uftc8inx 6459 8 between between IN cord-010092-uftc8inx 6459 9 the the DT cord-010092-uftc8inx 6459 10 donors donor NNS cord-010092-uftc8inx 6459 11 , , , cord-010092-uftc8inx 6459 12 indicating indicate VBG cord-010092-uftc8inx 6459 13 variability variability NN cord-010092-uftc8inx 6459 14 in in IN cord-010092-uftc8inx 6459 15 sugar sugar NN cord-010092-uftc8inx 6459 16 cleavage cleavage NN cord-010092-uftc8inx 6459 17 . . . cord-010092-uftc8inx 6460 1 Following follow VBG cord-010092-uftc8inx 6460 2 ristocetin ristocetin JJ cord-010092-uftc8inx 6460 3 stimulation stimulation NN cord-010092-uftc8inx 6460 4 , , , cord-010092-uftc8inx 6460 5 binding binding NN cord-010092-uftc8inx 6460 6 of of IN cord-010092-uftc8inx 6460 7 all all DT cord-010092-uftc8inx 6460 8 lectins lectin NNS cord-010092-uftc8inx 6460 9 increased increase VBD cord-010092-uftc8inx 6460 10 , , , cord-010092-uftc8inx 6460 11 and and CC cord-010092-uftc8inx 6460 12 again again RB cord-010092-uftc8inx 6460 13 there there EX cord-010092-uftc8inx 6460 14 was be VBD cord-010092-uftc8inx 6460 15 high high JJ cord-010092-uftc8inx 6460 16 variability variability NN cord-010092-uftc8inx 6460 17 in in IN cord-010092-uftc8inx 6460 18 the the DT cord-010092-uftc8inx 6460 19 responses response NNS cord-010092-uftc8inx 6460 20 , , , cord-010092-uftc8inx 6460 21 with with IN cord-010092-uftc8inx 6460 22 up up IN cord-010092-uftc8inx 6460 23 to to TO cord-010092-uftc8inx 6460 24 4-fold 4-fold CD cord-010092-uftc8inx 6460 25 higher high JJR cord-010092-uftc8inx 6460 26 binding binding NN cord-010092-uftc8inx 6460 27 in in IN cord-010092-uftc8inx 6460 28 platelets platelet NNS cord-010092-uftc8inx 6460 29 from from IN cord-010092-uftc8inx 6460 30 a a DT cord-010092-uftc8inx 6460 31 subset subset NN cord-010092-uftc8inx 6460 32 of of IN cord-010092-uftc8inx 6460 33 donors donor NNS cord-010092-uftc8inx 6460 34 . . . cord-010092-uftc8inx 6461 1 Of of IN cord-010092-uftc8inx 6461 2 particular particular JJ cord-010092-uftc8inx 6461 3 interest interest NN cord-010092-uftc8inx 6461 4 , , , cord-010092-uftc8inx 6461 5 aggregation aggregation NN cord-010092-uftc8inx 6461 6 in in IN cord-010092-uftc8inx 6461 7 response response NN cord-010092-uftc8inx 6461 8 to to IN cord-010092-uftc8inx 6461 9 arachidonic arachidonic JJ cord-010092-uftc8inx 6461 10 acid acid NN cord-010092-uftc8inx 6461 11 was be VBD cord-010092-uftc8inx 6461 12 observed observe VBN cord-010092-uftc8inx 6461 13 in in IN cord-010092-uftc8inx 6461 14 only only RB cord-010092-uftc8inx 6461 15 27 27 CD cord-010092-uftc8inx 6461 16 % % NN cord-010092-uftc8inx 6461 17 of of IN cord-010092-uftc8inx 6461 18 platelet platelet NN cord-010092-uftc8inx 6461 19 donations donation NNS cord-010092-uftc8inx 6461 20 tested test VBN cord-010092-uftc8inx 6461 21 ; ; : cord-010092-uftc8inx 6461 22 although although IN cord-010092-uftc8inx 6461 23 platelets platelet NNS cord-010092-uftc8inx 6461 24 from from IN cord-010092-uftc8inx 6461 25 non non JJ cord-010092-uftc8inx 6461 26 - - NNS cord-010092-uftc8inx 6461 27 responders responder NNS cord-010092-uftc8inx 6461 28 aggregated aggregate VBN cord-010092-uftc8inx 6461 29 in in IN cord-010092-uftc8inx 6461 30 response response NN cord-010092-uftc8inx 6461 31 to to IN cord-010092-uftc8inx 6461 32 the the DT cord-010092-uftc8inx 6461 33 collagen collagen NN cord-010092-uftc8inx 6461 34 and and CC cord-010092-uftc8inx 6461 35 thrombin thrombin NN cord-010092-uftc8inx 6461 36 . . . cord-010092-uftc8inx 6462 1 TxA TxA NNP cord-010092-uftc8inx 6462 2 2 2 CD cord-010092-uftc8inx 6462 3 was be VBD cord-010092-uftc8inx 6462 4 also also RB cord-010092-uftc8inx 6462 5 higher high JJR cord-010092-uftc8inx 6462 6 in in IN cord-010092-uftc8inx 6462 7 the the DT cord-010092-uftc8inx 6462 8 arachidonic arachidonic JJ cord-010092-uftc8inx 6462 9 acid acid JJ cord-010092-uftc8inx 6462 10 responders responder NNS cord-010092-uftc8inx 6462 11 ( ( -LRB- cord-010092-uftc8inx 6462 12 P p NN cord-010092-uftc8inx 6462 13 = = SYM cord-010092-uftc8inx 6462 14 0.027 0.027 CD cord-010092-uftc8inx 6462 15 ) ) -RRB- cord-010092-uftc8inx 6462 16 . . . cord-010092-uftc8inx 6463 1 There there EX cord-010092-uftc8inx 6463 2 were be VBD cord-010092-uftc8inx 6463 3 few few JJ cord-010092-uftc8inx 6463 4 associations association NNS cord-010092-uftc8inx 6463 5 between between IN cord-010092-uftc8inx 6463 6 platelet platelet NN cord-010092-uftc8inx 6463 7 parameters parameter NNS cord-010092-uftc8inx 6463 8 and and CC cord-010092-uftc8inx 6463 9 donor donor NN cord-010092-uftc8inx 6463 10 attributes attribute NNS cord-010092-uftc8inx 6463 11 , , , cord-010092-uftc8inx 6463 12 and and CC cord-010092-uftc8inx 6463 13 these these DT cord-010092-uftc8inx 6463 14 associations association NNS cord-010092-uftc8inx 6463 15 were be VBD cord-010092-uftc8inx 6463 16 typically typically RB cord-010092-uftc8inx 6463 17 weak weak JJ cord-010092-uftc8inx 6463 18 . . . cord-010092-uftc8inx 6464 1 pH pH NNP cord-010092-uftc8inx 6464 2 at at IN cord-010092-uftc8inx 6464 3 day day NN cord-010092-uftc8inx 6464 4 5 5 CD cord-010092-uftc8inx 6464 5 was be VBD cord-010092-uftc8inx 6464 6 weakly weakly RB cord-010092-uftc8inx 6464 7 associated associate VBN cord-010092-uftc8inx 6464 8 with with IN cord-010092-uftc8inx 6464 9 donor donor NN cord-010092-uftc8inx 6464 10 age age NN cord-010092-uftc8inx 6464 11 ( ( -LRB- cord-010092-uftc8inx 6464 12 P p NN cord-010092-uftc8inx 6464 13 = = SYM cord-010092-uftc8inx 6464 14 0.009 0.009 CD cord-010092-uftc8inx 6464 15 , , , cord-010092-uftc8inx 6464 16 R r NN cord-010092-uftc8inx 6464 17 2 2 CD cord-010092-uftc8inx 6464 18 = = SYM cord-010092-uftc8inx 6464 19 0.2613 0.2613 CD cord-010092-uftc8inx 6464 20 ) ) -RRB- cord-010092-uftc8inx 6464 21 but but CC cord-010092-uftc8inx 6464 22 not not RB cord-010092-uftc8inx 6464 23 BMI BMI NNP cord-010092-uftc8inx 6464 24 ( ( -LRB- cord-010092-uftc8inx 6464 25 P p NN cord-010092-uftc8inx 6464 26 = = SYM cord-010092-uftc8inx 6464 27 0.9143 0.9143 CD cord-010092-uftc8inx 6464 28 , , , cord-010092-uftc8inx 6464 29 R r NN cord-010092-uftc8inx 6464 30 2 2 CD cord-010092-uftc8inx 6464 31 < < XX cord-010092-uftc8inx 6464 32 0.001 0.001 CD cord-010092-uftc8inx 6464 33 ) ) -RRB- cord-010092-uftc8inx 6464 34 , , , cord-010092-uftc8inx 6464 35 with with IN cord-010092-uftc8inx 6464 36 a a DT cord-010092-uftc8inx 6464 37 trend trend NN cord-010092-uftc8inx 6464 38 towards towards IN cord-010092-uftc8inx 6464 39 lower low JJR cord-010092-uftc8inx 6464 40 pH ph NN cord-010092-uftc8inx 6464 41 in in IN cord-010092-uftc8inx 6464 42 younger young JJR cord-010092-uftc8inx 6464 43 donors donor NNS cord-010092-uftc8inx 6464 44 . . . cord-010092-uftc8inx 6465 1 Summary Summary NNP cord-010092-uftc8inx 6465 2 / / SYM cord-010092-uftc8inx 6465 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 6465 4 : : : cord-010092-uftc8inx 6466 1 These these DT cord-010092-uftc8inx 6466 2 data datum NNS cord-010092-uftc8inx 6466 3 indicate indicate VBP cord-010092-uftc8inx 6466 4 that that IN cord-010092-uftc8inx 6466 5 apheresis apheresis NN cord-010092-uftc8inx 6466 6 platelet platelet NN cord-010092-uftc8inx 6466 7 products product NNS cord-010092-uftc8inx 6466 8 are be VBP cord-010092-uftc8inx 6466 9 highly highly RB cord-010092-uftc8inx 6466 10 variable variable JJ cord-010092-uftc8inx 6466 11 . . . cord-010092-uftc8inx 6467 1 Whilst whilst IN cord-010092-uftc8inx 6467 2 donor donor NN cord-010092-uftc8inx 6467 3 characteristics characteristic NNS cord-010092-uftc8inx 6467 4 may may MD cord-010092-uftc8inx 6467 5 have have VB cord-010092-uftc8inx 6467 6 some some DT cord-010092-uftc8inx 6467 7 influence influence NN cord-010092-uftc8inx 6467 8 on on IN cord-010092-uftc8inx 6467 9 the the DT cord-010092-uftc8inx 6467 10 quality quality NN cord-010092-uftc8inx 6467 11 of of IN cord-010092-uftc8inx 6467 12 the the DT cord-010092-uftc8inx 6467 13 donated donate VBN cord-010092-uftc8inx 6467 14 platelet platelet NN cord-010092-uftc8inx 6467 15 product product NN cord-010092-uftc8inx 6467 16 , , , cord-010092-uftc8inx 6467 17 there there EX cord-010092-uftc8inx 6467 18 is be VBZ cord-010092-uftc8inx 6467 19 a a DT cord-010092-uftc8inx 6467 20 high high JJ cord-010092-uftc8inx 6467 21 level level NN cord-010092-uftc8inx 6467 22 of of IN cord-010092-uftc8inx 6467 23 inherent inherent JJ cord-010092-uftc8inx 6467 24 inter inter JJ cord-010092-uftc8inx 6467 25 - - JJ cord-010092-uftc8inx 6467 26 donor donor JJ cord-010092-uftc8inx 6467 27 biological biological JJ cord-010092-uftc8inx 6467 28 variability variability NN cord-010092-uftc8inx 6467 29 . . . cord-010092-uftc8inx 6468 1 A a DT cord-010092-uftc8inx 6468 2 much much RB cord-010092-uftc8inx 6468 3 larger large JJR cord-010092-uftc8inx 6468 4 sample sample NN cord-010092-uftc8inx 6468 5 size size NN cord-010092-uftc8inx 6468 6 is be VBZ cord-010092-uftc8inx 6468 7 required require VBN cord-010092-uftc8inx 6468 8 to to TO cord-010092-uftc8inx 6468 9 confirm confirm VB cord-010092-uftc8inx 6468 10 these these DT cord-010092-uftc8inx 6468 11 findings finding NNS cord-010092-uftc8inx 6468 12 , , , cord-010092-uftc8inx 6468 13 and and CC cord-010092-uftc8inx 6468 14 determine determine VB cord-010092-uftc8inx 6468 15 whether whether IN cord-010092-uftc8inx 6468 16 they -PRON- PRP cord-010092-uftc8inx 6468 17 have have VBP cord-010092-uftc8inx 6468 18 clinical clinical JJ cord-010092-uftc8inx 6468 19 implications implication NNS cord-010092-uftc8inx 6468 20 . . . cord-010092-uftc8inx 6469 1 Background background NN cord-010092-uftc8inx 6469 2 : : : cord-010092-uftc8inx 6470 1 The the DT cord-010092-uftc8inx 6470 2 frequency frequency NN cord-010092-uftc8inx 6470 3 of of IN cord-010092-uftc8inx 6470 4 beta beta NN cord-010092-uftc8inx 6470 5 thalassemia thalassemia NN cord-010092-uftc8inx 6470 6 mutations mutation NNS cord-010092-uftc8inx 6470 7 , , , cord-010092-uftc8inx 6470 8 and and CC cord-010092-uftc8inx 6470 9 thus thus RB cord-010092-uftc8inx 6470 10 , , , cord-010092-uftc8inx 6470 11 of of IN cord-010092-uftc8inx 6470 12 beta beta JJ cord-010092-uftc8inx 6470 13 thalassemia thalassemia NN cord-010092-uftc8inx 6470 14 heterozygotes heterozygote NNS cord-010092-uftc8inx 6470 15 ( ( -LRB- cord-010092-uftc8inx 6470 16 b b NNP cord-010092-uftc8inx 6470 17 - - HYPH cord-010092-uftc8inx 6470 18 thal thal NNP cord-010092-uftc8inx 6470 19 - - HYPH cord-010092-uftc8inx 6470 20 het het NNP cord-010092-uftc8inx 6470 21 ) ) -RRB- cord-010092-uftc8inx 6470 22 is be VBZ cord-010092-uftc8inx 6470 23 particularly particularly RB cord-010092-uftc8inx 6470 24 high high JJ cord-010092-uftc8inx 6470 25 in in IN cord-010092-uftc8inx 6470 26 certain certain JJ cord-010092-uftc8inx 6470 27 geographical geographical JJ cord-010092-uftc8inx 6470 28 regions region NNS cord-010092-uftc8inx 6470 29 . . . cord-010092-uftc8inx 6471 1 It -PRON- PRP cord-010092-uftc8inx 6471 2 has have VBZ cord-010092-uftc8inx 6471 3 been be VBN cord-010092-uftc8inx 6471 4 reported report VBN cord-010092-uftc8inx 6471 5 that that IN cord-010092-uftc8inx 6471 6 a a DT cord-010092-uftc8inx 6471 7 significant significant JJ cord-010092-uftc8inx 6471 8 proportion proportion NN cord-010092-uftc8inx 6471 9 of of IN cord-010092-uftc8inx 6471 10 donors donor NNS cord-010092-uftc8inx 6471 11 ( ( -LRB- cord-010092-uftc8inx 6471 12 occasionally occasionally RB cord-010092-uftc8inx 6471 13 more more JJR cord-010092-uftc8inx 6471 14 than than IN cord-010092-uftc8inx 6471 15 10 10 CD cord-010092-uftc8inx 6471 16 % % NN cord-010092-uftc8inx 6471 17 ) ) -RRB- cord-010092-uftc8inx 6471 18 are be VBP cord-010092-uftc8inx 6471 19 b b NN cord-010092-uftc8inx 6471 20 - - HYPH cord-010092-uftc8inx 6471 21 thal thal NNP cord-010092-uftc8inx 6471 22 - - HYPH cord-010092-uftc8inx 6471 23 het het NNP cord-010092-uftc8inx 6471 24 that that WDT cord-010092-uftc8inx 6471 25 meet meet VBP cord-010092-uftc8inx 6471 26 the the DT cord-010092-uftc8inx 6471 27 criteria criterion NNS cord-010092-uftc8inx 6471 28 for for IN cord-010092-uftc8inx 6471 29 blood blood NN cord-010092-uftc8inx 6471 30 donation donation NN cord-010092-uftc8inx 6471 31 ( ( -LRB- cord-010092-uftc8inx 6472 1 Hb Hb NNP cord-010092-uftc8inx 6472 2 > > XX cord-010092-uftc8inx 6472 3 13.5 13.5 CD cord-010092-uftc8inx 6472 4 g/ g/ JJ cord-010092-uftc8inx 6472 5 dL dl NN cord-010092-uftc8inx 6472 6 ) ) -RRB- cord-010092-uftc8inx 6472 7 . . . cord-010092-uftc8inx 6473 1 Red red JJ cord-010092-uftc8inx 6473 2 blood blood NN cord-010092-uftc8inx 6473 3 cells cell NNS cord-010092-uftc8inx 6473 4 ( ( -LRB- cord-010092-uftc8inx 6473 5 RBCs rbc NNS cord-010092-uftc8inx 6473 6 ) ) -RRB- cord-010092-uftc8inx 6473 7 of of IN cord-010092-uftc8inx 6473 8 b b NNP cord-010092-uftc8inx 6473 9 - - HYPH cord-010092-uftc8inx 6473 10 thal thal NNP cord-010092-uftc8inx 6473 11 - - HYPH cord-010092-uftc8inx 6473 12 het het NNP cord-010092-uftc8inx 6473 13 donors donor NNS cord-010092-uftc8inx 6473 14 are be VBP cord-010092-uftc8inx 6473 15 characterized characterize VBN cord-010092-uftc8inx 6473 16 , , , cord-010092-uftc8inx 6473 17 in in IN cord-010092-uftc8inx 6473 18 vivo vivo NN cord-010092-uftc8inx 6473 19 , , , cord-010092-uftc8inx 6473 20 by by IN cord-010092-uftc8inx 6473 21 particular particular JJ cord-010092-uftc8inx 6473 22 geometry geometry NN cord-010092-uftc8inx 6473 23 and and CC cord-010092-uftc8inx 6473 24 redox redox NN cord-010092-uftc8inx 6473 25 status status NN cord-010092-uftc8inx 6473 26 . . . cord-010092-uftc8inx 6474 1 Despite despite IN cord-010092-uftc8inx 6474 2 sporadic sporadic JJ cord-010092-uftc8inx 6474 3 indications indication NNS cord-010092-uftc8inx 6474 4 that that IN cord-010092-uftc8inx 6474 5 the the DT cord-010092-uftc8inx 6474 6 RBC RBC NNP cord-010092-uftc8inx 6474 7 storage storage NN cord-010092-uftc8inx 6474 8 lesion lesion NN cord-010092-uftc8inx 6474 9 may may MD cord-010092-uftc8inx 6474 10 be be VB cord-010092-uftc8inx 6474 11 milder mild JJR cord-010092-uftc8inx 6474 12 in in IN cord-010092-uftc8inx 6474 13 b b NNP cord-010092-uftc8inx 6474 14 - - HYPH cord-010092-uftc8inx 6474 15 thal thal NNP cord-010092-uftc8inx 6474 16 - - HYPH cord-010092-uftc8inx 6474 17 het het NNP cord-010092-uftc8inx 6474 18 , , , cord-010092-uftc8inx 6474 19 targeted target VBD cord-010092-uftc8inx 6474 20 research research NN cord-010092-uftc8inx 6474 21 on on IN cord-010092-uftc8inx 6474 22 this this DT cord-010092-uftc8inx 6474 23 donor donor NN cord-010092-uftc8inx 6474 24 group group NN cord-010092-uftc8inx 6474 25 is be VBZ cord-010092-uftc8inx 6474 26 still still RB cord-010092-uftc8inx 6474 27 missing miss VBG cord-010092-uftc8inx 6474 28 . . . cord-010092-uftc8inx 6475 1 Aims aim VBZ cord-010092-uftc8inx 6475 2 : : : cord-010092-uftc8inx 6476 1 The the DT cord-010092-uftc8inx 6476 2 aim aim NN cord-010092-uftc8inx 6476 3 of of IN cord-010092-uftc8inx 6476 4 this this DT cord-010092-uftc8inx 6476 5 study study NN cord-010092-uftc8inx 6476 6 was be VBD cord-010092-uftc8inx 6476 7 to to TO cord-010092-uftc8inx 6476 8 investigate investigate VB cord-010092-uftc8inx 6476 9 whether whether IN cord-010092-uftc8inx 6476 10 b b NN cord-010092-uftc8inx 6476 11 - - HYPH cord-010092-uftc8inx 6476 12 thal thal NNP cord-010092-uftc8inx 6476 13 - - HYPH cord-010092-uftc8inx 6476 14 het het NNP cord-010092-uftc8inx 6476 15 RBCs rbc NNS cord-010092-uftc8inx 6476 16 storage storage NN cord-010092-uftc8inx 6476 17 at at IN cord-010092-uftc8inx 6476 18 blood blood NN cord-010092-uftc8inx 6476 19 banks bank NNS cord-010092-uftc8inx 6476 20 leads lead VBZ cord-010092-uftc8inx 6476 21 to to IN cord-010092-uftc8inx 6476 22 a a DT cord-010092-uftc8inx 6476 23 distinctive distinctive JJ cord-010092-uftc8inx 6476 24 hemolytic hemolytic JJ cord-010092-uftc8inx 6476 25 , , , cord-010092-uftc8inx 6476 26 physiological physiological JJ cord-010092-uftc8inx 6476 27 and and CC cord-010092-uftc8inx 6476 28 redox redox JJ cord-010092-uftc8inx 6476 29 profile profile NN cord-010092-uftc8inx 6476 30 , , , cord-010092-uftc8inx 6476 31 thus thus RB cord-010092-uftc8inx 6476 32 , , , cord-010092-uftc8inx 6476 33 making make VBG cord-010092-uftc8inx 6476 34 b b NN cord-010092-uftc8inx 6476 35 - - HYPH cord-010092-uftc8inx 6476 36 thal thal NNP cord-010092-uftc8inx 6476 37 - - HYPH cord-010092-uftc8inx 6476 38 het het NNP cord-010092-uftc8inx 6476 39 a a DT cord-010092-uftc8inx 6476 40 unique unique JJ cord-010092-uftc8inx 6476 41 blood blood NN cord-010092-uftc8inx 6476 42 donor donor NN cord-010092-uftc8inx 6476 43 group group NN cord-010092-uftc8inx 6476 44 . . . cord-010092-uftc8inx 6477 1 Methods method NNS cord-010092-uftc8inx 6477 2 : : : cord-010092-uftc8inx 6477 3 Blood blood NN cord-010092-uftc8inx 6477 4 samples sample NNS cord-010092-uftc8inx 6477 5 from from IN cord-010092-uftc8inx 6477 6 10 10 CD cord-010092-uftc8inx 6477 7 healthy healthy JJ cord-010092-uftc8inx 6477 8 non non JJ cord-010092-uftc8inx 6477 9 - - JJ cord-010092-uftc8inx 6477 10 smoker smoker JJ cord-010092-uftc8inx 6477 11 donors donor NNS cord-010092-uftc8inx 6477 12 ( ( -LRB- cord-010092-uftc8inx 6477 13 5 5 CD cord-010092-uftc8inx 6477 14 b b NNP cord-010092-uftc8inx 6477 15 - - HYPH cord-010092-uftc8inx 6477 16 thal thal NNP cord-010092-uftc8inx 6477 17 - - HYPH cord-010092-uftc8inx 6477 18 het het NNP cord-010092-uftc8inx 6477 19 carriers carrier NNS cord-010092-uftc8inx 6477 20 and and CC cord-010092-uftc8inx 6477 21 5 5 CD cord-010092-uftc8inx 6477 22 controls control NNS cord-010092-uftc8inx 6477 23 ) ) -RRB- cord-010092-uftc8inx 6477 24 were be VBD cord-010092-uftc8inx 6477 25 analyzed analyze VBN cord-010092-uftc8inx 6477 26 before before IN cord-010092-uftc8inx 6477 27 and and CC cord-010092-uftc8inx 6477 28 after after IN cord-010092-uftc8inx 6477 29 preparation preparation NN cord-010092-uftc8inx 6477 30 and and CC cord-010092-uftc8inx 6477 31 storage storage NN cord-010092-uftc8inx 6477 32 of of IN cord-010092-uftc8inx 6477 33 leukoreduced leukoreduced JJ cord-010092-uftc8inx 6477 34 packed pack VBN cord-010092-uftc8inx 6477 35 RBC RBC NNP cord-010092-uftc8inx 6477 36 units unit NNS cord-010092-uftc8inx 6477 37 in in IN cord-010092-uftc8inx 6477 38 CPD CPD NNP cord-010092-uftc8inx 6477 39 / / SYM cord-010092-uftc8inx 6477 40 SAGM SAGM NNP cord-010092-uftc8inx 6477 41 at at IN cord-010092-uftc8inx 6477 42 various various JJ cord-010092-uftc8inx 6477 43 time time NN cord-010092-uftc8inx 6477 44 intervals interval NNS cord-010092-uftc8inx 6477 45 . . . cord-010092-uftc8inx 6478 1 Susceptibility susceptibility NN cord-010092-uftc8inx 6478 2 in in IN cord-010092-uftc8inx 6478 3 hemolysis hemolysis NN cord-010092-uftc8inx 6478 4 ( ( -LRB- cord-010092-uftc8inx 6478 5 in in IN cord-010092-uftc8inx 6478 6 the the DT cord-010092-uftc8inx 6478 7 presence presence NN cord-010092-uftc8inx 6478 8 / / SYM cord-010092-uftc8inx 6478 9 absence absence NN cord-010092-uftc8inx 6478 10 of of IN cord-010092-uftc8inx 6478 11 oxidative oxidative NN cord-010092-uftc8inx 6478 12 , , , cord-010092-uftc8inx 6478 13 mechanic mechanic NN cord-010092-uftc8inx 6478 14 and and CC cord-010092-uftc8inx 6478 15 osmotic osmotic JJ cord-010092-uftc8inx 6478 16 stimuli stimulus NNS cord-010092-uftc8inx 6478 17 ) ) -RRB- cord-010092-uftc8inx 6478 18 , , , cord-010092-uftc8inx 6478 19 redox redox NN cord-010092-uftc8inx 6478 20 status status NN cord-010092-uftc8inx 6478 21 ( ( -LRB- cord-010092-uftc8inx 6478 22 lipid lipid NN cord-010092-uftc8inx 6478 23 peroxidation peroxidation NN cord-010092-uftc8inx 6478 24 , , , cord-010092-uftc8inx 6478 25 reactive reactive JJ cord-010092-uftc8inx 6478 26 oxygen oxygen NN cord-010092-uftc8inx 6478 27 species specie NNS cord-010092-uftc8inx 6478 28 ( ( -LRB- cord-010092-uftc8inx 6478 29 ROS ROS NNP cord-010092-uftc8inx 6478 30 ) ) -RRB- cord-010092-uftc8inx 6478 31 accumulation accumulation NN cord-010092-uftc8inx 6478 32 , , , cord-010092-uftc8inx 6478 33 antioxidant antioxidant NN cord-010092-uftc8inx 6478 34 capacity capacity NN cord-010092-uftc8inx 6478 35 ) ) -RRB- cord-010092-uftc8inx 6478 36 , , . cord-010092-uftc8inx 6479 1 intracellular intracellular JJ cord-010092-uftc8inx 6480 1 Ca ca NN cord-010092-uftc8inx 6480 2 2 2 CD cord-010092-uftc8inx 6480 3 + + SYM cord-010092-uftc8inx 6480 4 and and CC cord-010092-uftc8inx 6480 5 proteasomal proteasomal JJ cord-010092-uftc8inx 6480 6 activities activity NNS cord-010092-uftc8inx 6480 7 were be VBD cord-010092-uftc8inx 6480 8 determined determine VBN cord-010092-uftc8inx 6480 9 . . . cord-010092-uftc8inx 6481 1 For for IN cord-010092-uftc8inx 6481 2 statistical statistical JJ cord-010092-uftc8inx 6481 3 analysis analysis NN cord-010092-uftc8inx 6481 4 , , , cord-010092-uftc8inx 6481 5 significance significance NN cord-010092-uftc8inx 6481 6 was be VBD cord-010092-uftc8inx 6481 7 accepted accept VBN cord-010092-uftc8inx 6481 8 at at IN cord-010092-uftc8inx 6481 9 P p NN cord-010092-uftc8inx 6481 10 < < XX cord-010092-uftc8inx 6481 11 0.05 0.05 CD cord-010092-uftc8inx 6481 12 . . . cord-010092-uftc8inx 6482 1 samples sample NNS cord-010092-uftc8inx 6482 2 from from IN cord-010092-uftc8inx 6482 3 the the DT cord-010092-uftc8inx 6482 4 red red JJ cord-010092-uftc8inx 6482 5 cell cell NN cord-010092-uftc8inx 6482 6 units unit NNS cord-010092-uftc8inx 6482 7 were be VBD cord-010092-uftc8inx 6482 8 collected collect VBN cord-010092-uftc8inx 6482 9 aseptically aseptically RB cord-010092-uftc8inx 6482 10 , , , cord-010092-uftc8inx 6482 11 processed process VBN cord-010092-uftc8inx 6482 12 ( ( -LRB- cord-010092-uftc8inx 6482 13 dual dual JJ cord-010092-uftc8inx 6482 14 centrifugation centrifugation NN cord-010092-uftc8inx 6482 15 at at IN cord-010092-uftc8inx 6482 16 3,000 3,000 CD cord-010092-uftc8inx 6482 17 g g NN cord-010092-uftc8inx 6482 18 for for IN cord-010092-uftc8inx 6482 19 15 15 CD cord-010092-uftc8inx 6482 20 min min NN cord-010092-uftc8inx 6482 21 ) ) -RRB- cord-010092-uftc8inx 6482 22 and and CC cord-010092-uftc8inx 6482 23 stored store VBN cord-010092-uftc8inx 6482 24 at at IN cord-010092-uftc8inx 6482 25 À80 À80 NNP cord-010092-uftc8inx 6482 26 ° ° NN cord-010092-uftc8inx 6482 27 C C NNP cord-010092-uftc8inx 6482 28 . . . cord-010092-uftc8inx 6483 1 Processed process VBN cord-010092-uftc8inx 6483 2 samples sample NNS cord-010092-uftc8inx 6483 3 were be VBD cord-010092-uftc8inx 6483 4 thawed thaw VBN cord-010092-uftc8inx 6483 5 , , , cord-010092-uftc8inx 6483 6 and and CC cord-010092-uftc8inx 6483 7 then then RB cord-010092-uftc8inx 6483 8 analysed analyse VBD cord-010092-uftc8inx 6483 9 using use VBG cord-010092-uftc8inx 6483 10 the the DT cord-010092-uftc8inx 6483 11 Nanosight Nanosight NNP cord-010092-uftc8inx 6483 12 NS300 NS300 NNP cord-010092-uftc8inx 6483 13 nanoparticle nanoparticle NN cord-010092-uftc8inx 6483 14 tracking tracking NN cord-010092-uftc8inx 6483 15 analysis analysis NN cord-010092-uftc8inx 6483 16 system system NN cord-010092-uftc8inx 6483 17 ( ( -LRB- cord-010092-uftc8inx 6483 18 Malvern Malvern NNP cord-010092-uftc8inx 6483 19 Instruments Instruments NNP cord-010092-uftc8inx 6483 20 ) ) -RRB- cord-010092-uftc8inx 6483 21 . . . cord-010092-uftc8inx 6484 1 Samples sample NNS cord-010092-uftc8inx 6484 2 from from IN cord-010092-uftc8inx 6484 3 all all DT cord-010092-uftc8inx 6484 4 time time NN cord-010092-uftc8inx 6484 5 - - HYPH cord-010092-uftc8inx 6484 6 points point NNS cord-010092-uftc8inx 6484 7 from from IN cord-010092-uftc8inx 6484 8 each each DT cord-010092-uftc8inx 6484 9 unit unit NN cord-010092-uftc8inx 6484 10 were be VBD cord-010092-uftc8inx 6484 11 analysed analyse VBN cord-010092-uftc8inx 6484 12 on on IN cord-010092-uftc8inx 6484 13 the the DT cord-010092-uftc8inx 6484 14 same same JJ cord-010092-uftc8inx 6484 15 day day NN cord-010092-uftc8inx 6484 16 . . . cord-010092-uftc8inx 6485 1 Data datum NNS cord-010092-uftc8inx 6485 2 were be VBD cord-010092-uftc8inx 6485 3 analysed analyse VBN cord-010092-uftc8inx 6485 4 by by IN cord-010092-uftc8inx 6485 5 one one CD cord-010092-uftc8inx 6485 6 - - HYPH cord-010092-uftc8inx 6485 7 way way NN cord-010092-uftc8inx 6485 8 ANOVA anova NN cord-010092-uftc8inx 6485 9 with with IN cord-010092-uftc8inx 6485 10 Bonferroni Bonferroni NNP cord-010092-uftc8inx 6485 11 's 's POS cord-010092-uftc8inx 6485 12 multiple multiple JJ cord-010092-uftc8inx 6485 13 comparisons comparison NNS cord-010092-uftc8inx 6485 14 test test NN cord-010092-uftc8inx 6485 15 . . . cord-010092-uftc8inx 6486 1 Results result NNS cord-010092-uftc8inx 6486 2 : : : cord-010092-uftc8inx 6487 1 At at IN cord-010092-uftc8inx 6487 2 d2 d2 NN cord-010092-uftc8inx 6487 3 , , , cord-010092-uftc8inx 6487 4 red red JJ cord-010092-uftc8inx 6487 5 cell cell NN cord-010092-uftc8inx 6487 6 units unit NNS cord-010092-uftc8inx 6487 7 contained contain VBD cord-010092-uftc8inx 6487 8 an an DT cord-010092-uftc8inx 6487 9 average average NN cord-010092-uftc8inx 6487 10 of of IN cord-010092-uftc8inx 6487 11 8.1 8.1 CD cord-010092-uftc8inx 6487 12 9 9 CD cord-010092-uftc8inx 6487 13 10 10 CD cord-010092-uftc8inx 6487 14 9 9 CD cord-010092-uftc8inx 6487 15 AE ae NN cord-010092-uftc8inx 6488 1 4.0 4.0 CD cord-010092-uftc8inx 6488 2 9 9 CD cord-010092-uftc8inx 6488 3 10 10 CD cord-010092-uftc8inx 6488 4 9 9 CD cord-010092-uftc8inx 6488 5 MVs/ mvs/ NN cord-010092-uftc8inx 6488 6 mL. mL. NNS cord-010092-uftc8inx 6489 1 The the DT cord-010092-uftc8inx 6489 2 mean mean JJ cord-010092-uftc8inx 6489 3 size size NN cord-010092-uftc8inx 6489 4 of of IN cord-010092-uftc8inx 6489 5 these these DT cord-010092-uftc8inx 6489 6 MVs mv NNS cord-010092-uftc8inx 6489 7 was be VBD cord-010092-uftc8inx 6489 8 112.8 112.8 CD cord-010092-uftc8inx 6489 9 AE AE NNP cord-010092-uftc8inx 6489 10 10.5 10.5 CD cord-010092-uftc8inx 6489 11 nm nm NN cord-010092-uftc8inx 6489 12 and and CC cord-010092-uftc8inx 6489 13 the the DT cord-010092-uftc8inx 6489 14 mode mode NN cord-010092-uftc8inx 6489 15 size size NN cord-010092-uftc8inx 6489 16 was be VBD cord-010092-uftc8inx 6489 17 79.9 79.9 CD cord-010092-uftc8inx 6489 18 AE AE NNP cord-010092-uftc8inx 6489 19 10.3 10.3 CD cord-010092-uftc8inx 6489 20 nm nm NN cord-010092-uftc8inx 6489 21 . . . cord-010092-uftc8inx 6490 1 The the DT cord-010092-uftc8inx 6490 2 concentration concentration NN cord-010092-uftc8inx 6490 3 of of IN cord-010092-uftc8inx 6490 4 MVs mv NNS cord-010092-uftc8inx 6490 5 increased increase VBD cord-010092-uftc8inx 6490 6 gradually gradually RB cord-010092-uftc8inx 6490 7 throughout throughout IN cord-010092-uftc8inx 6490 8 storage storage NN cord-010092-uftc8inx 6490 9 ( ( -LRB- cord-010092-uftc8inx 6490 10 P p NN cord-010092-uftc8inx 6490 11 = = SYM cord-010092-uftc8inx 6490 12 0.0276 0.0276 CD cord-010092-uftc8inx 6490 13 ) ) -RRB- cord-010092-uftc8inx 6490 14 , , , cord-010092-uftc8inx 6490 15 reaching reach VBG cord-010092-uftc8inx 6490 16 a a DT cord-010092-uftc8inx 6490 17 maximum maximum NN cord-010092-uftc8inx 6490 18 at at IN cord-010092-uftc8inx 6490 19 d42 d42 DT cord-010092-uftc8inx 6490 20 of of IN cord-010092-uftc8inx 6490 21 32.4 32.4 CD cord-010092-uftc8inx 6490 22 9 9 CD cord-010092-uftc8inx 6490 23 10 10 CD cord-010092-uftc8inx 6490 24 9 9 CD cord-010092-uftc8inx 6490 25 AE ae NN cord-010092-uftc8inx 6491 1 1.8 1.8 CD cord-010092-uftc8inx 6491 2 9 9 CD cord-010092-uftc8inx 6491 3 10 10 CD cord-010092-uftc8inx 6491 4 9 9 CD cord-010092-uftc8inx 6491 5 MVs/ mvs/ NN cord-010092-uftc8inx 6492 1 mL. mL. NNP cord-010092-uftc8inx 6492 2 Both both PDT cord-010092-uftc8inx 6492 3 the the DT cord-010092-uftc8inx 6492 4 mean mean NN cord-010092-uftc8inx 6492 5 ( ( -LRB- cord-010092-uftc8inx 6492 6 P p NN cord-010092-uftc8inx 6492 7 < < XX cord-010092-uftc8inx 6492 8 0.0001 0.0001 CD cord-010092-uftc8inx 6492 9 ) ) -RRB- cord-010092-uftc8inx 6492 10 and and CC cord-010092-uftc8inx 6492 11 mode mode NN cord-010092-uftc8inx 6492 12 ( ( -LRB- cord-010092-uftc8inx 6492 13 P p NN cord-010092-uftc8inx 6492 14 < < XX cord-010092-uftc8inx 6492 15 0.0001 0.0001 CD cord-010092-uftc8inx 6492 16 ) ) -RRB- cord-010092-uftc8inx 6492 17 size size NN cord-010092-uftc8inx 6492 18 of of IN cord-010092-uftc8inx 6492 19 the the DT cord-010092-uftc8inx 6492 20 MVs MVs NNPS cord-010092-uftc8inx 6492 21 increased increase VBD cord-010092-uftc8inx 6492 22 during during IN cord-010092-uftc8inx 6492 23 storage storage NN cord-010092-uftc8inx 6492 24 ; ; : cord-010092-uftc8inx 6492 25 however however RB cord-010092-uftc8inx 6492 26 , , , cord-010092-uftc8inx 6492 27 this this DT cord-010092-uftc8inx 6492 28 size size NN cord-010092-uftc8inx 6492 29 increase increase NN cord-010092-uftc8inx 6492 30 primarily primarily RB cord-010092-uftc8inx 6492 31 occurred occur VBD cord-010092-uftc8inx 6492 32 in in IN cord-010092-uftc8inx 6492 33 the the DT cord-010092-uftc8inx 6492 34 first first JJ cord-010092-uftc8inx 6492 35 week week NN cord-010092-uftc8inx 6492 36 of of IN cord-010092-uftc8inx 6492 37 storage storage NN cord-010092-uftc8inx 6492 38 ( ( -LRB- cord-010092-uftc8inx 6492 39 d2 d2 NN cord-010092-uftc8inx 6492 40 vs. vs. FW cord-010092-uftc8inx 6492 41 d7 d7 NN cord-010092-uftc8inx 6492 42 : : : cord-010092-uftc8inx 6493 1 P p NN cord-010092-uftc8inx 6493 2 < < XX cord-010092-uftc8inx 6493 3 0.0001 0.0001 CD cord-010092-uftc8inx 6493 4 for for IN cord-010092-uftc8inx 6493 5 both both DT cord-010092-uftc8inx 6493 6 mean mean VB cord-010092-uftc8inx 6493 7 and and CC cord-010092-uftc8inx 6493 8 mode mode NN cord-010092-uftc8inx 6493 9 ) ) -RRB- cord-010092-uftc8inx 6493 10 . . . cord-010092-uftc8inx 6494 1 By by IN cord-010092-uftc8inx 6494 2 d42 d42 CD cord-010092-uftc8inx 6494 3 , , , cord-010092-uftc8inx 6494 4 mean mean VB cord-010092-uftc8inx 6494 5 and and CC cord-010092-uftc8inx 6494 6 mode mode NN cord-010092-uftc8inx 6494 7 size size NN cord-010092-uftc8inx 6494 8 of of IN cord-010092-uftc8inx 6494 9 MVs mv NNS cord-010092-uftc8inx 6494 10 was be VBD cord-010092-uftc8inx 6494 11 176.1 176.1 CD cord-010092-uftc8inx 6494 12 AE AE NNP cord-010092-uftc8inx 6494 13 4.8 4.8 CD cord-010092-uftc8inx 6494 14 nm nm NN cord-010092-uftc8inx 6494 15 and and CC cord-010092-uftc8inx 6494 16 171.8 171.8 CD cord-010092-uftc8inx 6494 17 AE AE NNP cord-010092-uftc8inx 6494 18 5.6 5.6 CD cord-010092-uftc8inx 6494 19 nm nm NNP cord-010092-uftc8inx 6494 20 Summary Summary NNP cord-010092-uftc8inx 6494 21 / / SYM cord-010092-uftc8inx 6494 22 Conclusions Conclusions NNPS cord-010092-uftc8inx 6494 23 : : : cord-010092-uftc8inx 6495 1 Nanoparticle Nanoparticle NNP cord-010092-uftc8inx 6495 2 tracking tracking NN cord-010092-uftc8inx 6495 3 analysis analysis NN cord-010092-uftc8inx 6495 4 demonstrated demonstrate VBD cord-010092-uftc8inx 6495 5 the the DT cord-010092-uftc8inx 6495 6 presence presence NN cord-010092-uftc8inx 6495 7 of of IN cord-010092-uftc8inx 6495 8 MVs MVs NNPS cord-010092-uftc8inx 6495 9 smaller small JJR cord-010092-uftc8inx 6495 10 than than IN cord-010092-uftc8inx 6495 11 400 400 CD cord-010092-uftc8inx 6495 12 nm nm CD cord-010092-uftc8inx 6495 13 in in IN cord-010092-uftc8inx 6495 14 red red JJ cord-010092-uftc8inx 6495 15 cell cell NN cord-010092-uftc8inx 6495 16 units unit NNS cord-010092-uftc8inx 6495 17 . . . cord-010092-uftc8inx 6496 1 Both both DT cord-010092-uftc8inx 6496 2 the the DT cord-010092-uftc8inx 6496 3 concentration concentration NN cord-010092-uftc8inx 6496 4 and and CC cord-010092-uftc8inx 6496 5 size size NN cord-010092-uftc8inx 6496 6 of of IN cord-010092-uftc8inx 6496 7 MVs MVs NNPS cord-010092-uftc8inx 6496 8 present present JJ cord-010092-uftc8inx 6496 9 in in IN cord-010092-uftc8inx 6496 10 red red JJ cord-010092-uftc8inx 6496 11 cell cell NN cord-010092-uftc8inx 6496 12 units unit NNS cord-010092-uftc8inx 6496 13 increased increase VBD cord-010092-uftc8inx 6496 14 during during IN cord-010092-uftc8inx 6496 15 the the DT cord-010092-uftc8inx 6496 16 42 42 CD cord-010092-uftc8inx 6496 17 days day NNS cord-010092-uftc8inx 6496 18 of of IN cord-010092-uftc8inx 6496 19 routine routine JJ cord-010092-uftc8inx 6496 20 storage storage NN cord-010092-uftc8inx 6496 21 . . . cord-010092-uftc8inx 6497 1 The the DT cord-010092-uftc8inx 6497 2 concentration concentration NN cord-010092-uftc8inx 6497 3 of of IN cord-010092-uftc8inx 6497 4 these these DT cord-010092-uftc8inx 6497 5 MVs mv NNS cord-010092-uftc8inx 6497 6 was be VBD cord-010092-uftc8inx 6497 7 approximately approximately RB cord-010092-uftc8inx 6497 8 100-fold 100-fold CD cord-010092-uftc8inx 6497 9 higher high JJR cord-010092-uftc8inx 6497 10 than than IN cord-010092-uftc8inx 6497 11 we -PRON- PRP cord-010092-uftc8inx 6497 12 had have VBD cord-010092-uftc8inx 6497 13 previously previously RB cord-010092-uftc8inx 6497 14 detected detect VBN cord-010092-uftc8inx 6497 15 using use VBG cord-010092-uftc8inx 6497 16 flow flow NN cord-010092-uftc8inx 6497 17 cytometry cytometry NN cord-010092-uftc8inx 6497 18 ( ( -LRB- cord-010092-uftc8inx 6497 19 Aung Aung NNP cord-010092-uftc8inx 6497 20 , , , cord-010092-uftc8inx 6497 21 Pathology Pathology NNP cord-010092-uftc8inx 6497 22 , , , cord-010092-uftc8inx 6497 23 2017 2017 CD cord-010092-uftc8inx 6497 24 ) ) -RRB- cord-010092-uftc8inx 6497 25 indicating indicate VBG cord-010092-uftc8inx 6497 26 the the DT cord-010092-uftc8inx 6497 27 advantages advantage NNS cord-010092-uftc8inx 6497 28 of of IN cord-010092-uftc8inx 6497 29 more more RBR cord-010092-uftc8inx 6497 30 sensitive sensitive JJ cord-010092-uftc8inx 6497 31 techniques technique NNS cord-010092-uftc8inx 6497 32 in in IN cord-010092-uftc8inx 6497 33 characterisation characterisation NN cord-010092-uftc8inx 6497 34 of of IN cord-010092-uftc8inx 6497 35 MVs mv NNS cord-010092-uftc8inx 6497 36 . . . cord-010092-uftc8inx 6498 1 Background background NN cord-010092-uftc8inx 6498 2 : : : cord-010092-uftc8inx 6499 1 The the DT cord-010092-uftc8inx 6499 2 lack lack NN cord-010092-uftc8inx 6499 3 of of IN cord-010092-uftc8inx 6499 4 availability availability NN cord-010092-uftc8inx 6499 5 of of IN cord-010092-uftc8inx 6499 6 sterile sterile JJ cord-010092-uftc8inx 6499 7 saline saline NN cord-010092-uftc8inx 6499 8 in in IN cord-010092-uftc8inx 6499 9 a a DT cord-010092-uftc8inx 6499 10 format format NN cord-010092-uftc8inx 6499 11 suitable suitable JJ cord-010092-uftc8inx 6499 12 for for IN cord-010092-uftc8inx 6499 13 use use NN cord-010092-uftc8inx 6499 14 in in IN cord-010092-uftc8inx 6499 15 blood blood NN cord-010092-uftc8inx 6499 16 centers center NNS cord-010092-uftc8inx 6499 17 for for IN cord-010092-uftc8inx 6499 18 manual manual JJ cord-010092-uftc8inx 6499 19 washing washing NN cord-010092-uftc8inx 6499 20 has have VBZ cord-010092-uftc8inx 6499 21 led lead VBN cord-010092-uftc8inx 6499 22 to to IN cord-010092-uftc8inx 6499 23 an an DT cord-010092-uftc8inx 6499 24 urgent urgent JJ cord-010092-uftc8inx 6499 25 need need NN cord-010092-uftc8inx 6499 26 for for IN cord-010092-uftc8inx 6499 27 blood blood NN cord-010092-uftc8inx 6499 28 services service NNS cord-010092-uftc8inx 6499 29 to to TO cord-010092-uftc8inx 6499 30 consider consider VB cord-010092-uftc8inx 6499 31 alternative alternative JJ cord-010092-uftc8inx 6499 32 methods method NNS cord-010092-uftc8inx 6499 33 . . . cord-010092-uftc8inx 6500 1 For for IN cord-010092-uftc8inx 6500 2 operational operational JJ cord-010092-uftc8inx 6500 3 flexibility flexibility NN cord-010092-uftc8inx 6500 4 it -PRON- PRP cord-010092-uftc8inx 6500 5 would would MD cord-010092-uftc8inx 6500 6 be be VB cord-010092-uftc8inx 6500 7 desirable desirable JJ cord-010092-uftc8inx 6500 8 to to TO cord-010092-uftc8inx 6500 9 be be VB cord-010092-uftc8inx 6500 10 able able JJ cord-010092-uftc8inx 6500 11 to to TO cord-010092-uftc8inx 6500 12 produce produce VB cord-010092-uftc8inx 6500 13 a a DT cord-010092-uftc8inx 6500 14 washed wash VBN cord-010092-uftc8inx 6500 15 RBC RBC NNP cord-010092-uftc8inx 6500 16 unit unit NN cord-010092-uftc8inx 6500 17 that that WDT cord-010092-uftc8inx 6500 18 had have VBD cord-010092-uftc8inx 6500 19 a a DT cord-010092-uftc8inx 6500 20 shelf shelf NN cord-010092-uftc8inx 6500 21 life life NN cord-010092-uftc8inx 6500 22 longer long JJR cord-010092-uftc8inx 6500 23 than than IN cord-010092-uftc8inx 6500 24 24 24 CD cord-010092-uftc8inx 6500 25 h. h. NNP cord-010092-uftc8inx 6500 26 Aims aim NNS cord-010092-uftc8inx 6500 27 : : : cord-010092-uftc8inx 6501 1 The the DT cord-010092-uftc8inx 6501 2 aim aim NN cord-010092-uftc8inx 6501 3 of of IN cord-010092-uftc8inx 6501 4 this this DT cord-010092-uftc8inx 6501 5 study study NN cord-010092-uftc8inx 6501 6 was be VBD cord-010092-uftc8inx 6501 7 to to TO cord-010092-uftc8inx 6501 8 validate validate VB cord-010092-uftc8inx 6501 9 the the DT cord-010092-uftc8inx 6501 10 manual manual JJ cord-010092-uftc8inx 6501 11 method method NN cord-010092-uftc8inx 6501 12 for for IN cord-010092-uftc8inx 6501 13 washing washing NN cord-010092-uftc8inx 6501 14 RBCs rbc NNS cord-010092-uftc8inx 6501 15 using use VBG cord-010092-uftc8inx 6501 16 SAGM SAGM NNP cord-010092-uftc8inx 6501 17 solution solution NN cord-010092-uftc8inx 6501 18 both both DT cord-010092-uftc8inx 6501 19 as as IN cord-010092-uftc8inx 6501 20 wash wash NN cord-010092-uftc8inx 6501 21 and and CC cord-010092-uftc8inx 6501 22 storage storage NN cord-010092-uftc8inx 6501 23 solution solution NN cord-010092-uftc8inx 6501 24 and and CC cord-010092-uftc8inx 6501 25 to to TO cord-010092-uftc8inx 6501 26 ascertain ascertain VB cord-010092-uftc8inx 6501 27 whether whether IN cord-010092-uftc8inx 6501 28 an an DT cord-010092-uftc8inx 6501 29 extended extended JJ cord-010092-uftc8inx 6501 30 storage storage NN cord-010092-uftc8inx 6501 31 period period NN cord-010092-uftc8inx 6501 32 for for IN cord-010092-uftc8inx 6501 33 washed washed JJ cord-010092-uftc8inx 6501 34 RBCs rbc NNS cord-010092-uftc8inx 6501 35 may may MD cord-010092-uftc8inx 6501 36 be be VB cord-010092-uftc8inx 6501 37 feasible feasible JJ cord-010092-uftc8inx 6501 38 . . . cord-010092-uftc8inx 6502 1 Methods method NNS cord-010092-uftc8inx 6502 2 : : : cord-010092-uftc8inx 6503 1 Six six CD cord-010092-uftc8inx 6503 2 14 14 CD cord-010092-uftc8inx 6503 3 day day NN cord-010092-uftc8inx 6503 4 old old JJ cord-010092-uftc8inx 6503 5 leukocyte leukocyte NN cord-010092-uftc8inx 6503 6 depleted deplete VBD cord-010092-uftc8inx 6503 7 red red JJ cord-010092-uftc8inx 6503 8 blood blood NN cord-010092-uftc8inx 6503 9 cells cell NNS cord-010092-uftc8inx 6503 10 ( ( -LRB- cord-010092-uftc8inx 6503 11 LD LD NNP cord-010092-uftc8inx 6503 12 - - HYPH cord-010092-uftc8inx 6503 13 RBC RBC NNP cord-010092-uftc8inx 6503 14 ) ) -RRB- cord-010092-uftc8inx 6503 15 and and CC cord-010092-uftc8inx 6503 16 six six CD cord-010092-uftc8inx 6503 17 4 4 CD cord-010092-uftc8inx 6503 18 day day NN cord-010092-uftc8inx 6503 19 old old JJ cord-010092-uftc8inx 6503 20 LD LD NNP cord-010092-uftc8inx 6503 21 - - HYPH cord-010092-uftc8inx 6503 22 RBCs rbc NNS cord-010092-uftc8inx 6503 23 were be VBD cord-010092-uftc8inx 6503 24 manually manually RB cord-010092-uftc8inx 6503 25 washed wash VBN cord-010092-uftc8inx 6503 26 and and CC cord-010092-uftc8inx 6503 27 stored store VBN cord-010092-uftc8inx 6503 28 in in IN cord-010092-uftc8inx 6503 29 SAGM SAGM NNP cord-010092-uftc8inx 6503 30 , , , cord-010092-uftc8inx 6503 31 and and CC cord-010092-uftc8inx 6503 32 half half NN cord-010092-uftc8inx 6503 33 of of IN cord-010092-uftc8inx 6503 34 the the DT cord-010092-uftc8inx 6503 35 units unit NNS cord-010092-uftc8inx 6503 36 were be VBD cord-010092-uftc8inx 6503 37 pre pre JJ cord-010092-uftc8inx 6503 38 - - VBN cord-010092-uftc8inx 6503 39 stored store VBN cord-010092-uftc8inx 6503 40 irradiated irradiate VBN cord-010092-uftc8inx 6503 41 ( ( -LRB- cord-010092-uftc8inx 6503 42 25 25 CD cord-010092-uftc8inx 6503 43 Gy Gy NNP cord-010092-uftc8inx 6503 44 ) ) -RRB- cord-010092-uftc8inx 6503 45 . . . cord-010092-uftc8inx 6504 1 A a DT cord-010092-uftc8inx 6504 2 volume volume NN cord-010092-uftc8inx 6504 3 of of IN cord-010092-uftc8inx 6504 4 350 350 CD cord-010092-uftc8inx 6504 5 mL ml NN cord-010092-uftc8inx 6504 6 wash wash NN cord-010092-uftc8inx 6504 7 solution solution NN cord-010092-uftc8inx 6504 8 ( ( -LRB- cord-010092-uftc8inx 6504 9 SAGM SAGM NNP cord-010092-uftc8inx 6504 10 ) ) -RRB- cord-010092-uftc8inx 6504 11 was be VBD cord-010092-uftc8inx 6504 12 added add VBN cord-010092-uftc8inx 6504 13 to to IN cord-010092-uftc8inx 6504 14 the the DT cord-010092-uftc8inx 6504 15 LD LD NNP cord-010092-uftc8inx 6504 16 - - HYPH cord-010092-uftc8inx 6504 17 RBSs rbs NNS cord-010092-uftc8inx 6504 18 by by IN cord-010092-uftc8inx 6504 19 sterile sterile JJ cord-010092-uftc8inx 6504 20 connection connection NN cord-010092-uftc8inx 6504 21 . . . cord-010092-uftc8inx 6505 1 After after IN cord-010092-uftc8inx 6505 2 mixing mix VBG cord-010092-uftc8inx 6505 3 the the DT cord-010092-uftc8inx 6505 4 units unit NNS cord-010092-uftc8inx 6505 5 were be VBD cord-010092-uftc8inx 6505 6 centrifuged centrifuge VBN cord-010092-uftc8inx 6505 7 for for IN cord-010092-uftc8inx 6505 8 6.5 6.5 CD cord-010092-uftc8inx 6505 9 min min NN cord-010092-uftc8inx 6505 10 at at IN cord-010092-uftc8inx 6505 11 2888 2888 CD cord-010092-uftc8inx 6505 12 9 9 CD cord-010092-uftc8inx 6505 13 g g NN cord-010092-uftc8inx 6505 14 at at IN cord-010092-uftc8inx 6505 15 4 4 CD cord-010092-uftc8inx 6505 16 ° ° NN cord-010092-uftc8inx 6505 17 C c NN cord-010092-uftc8inx 6505 18 ( ( -LRB- cord-010092-uftc8inx 6505 19 Hettich Hettich NNP cord-010092-uftc8inx 6505 20 Roto Roto NNP cord-010092-uftc8inx 6505 21 Silenta Silenta NNP cord-010092-uftc8inx 6505 22 630 630 CD cord-010092-uftc8inx 6505 23 RS rs NN cord-010092-uftc8inx 6505 24 ) ) -RRB- cord-010092-uftc8inx 6505 25 before before IN cord-010092-uftc8inx 6505 26 removing remove VBG cord-010092-uftc8inx 6505 27 the the DT cord-010092-uftc8inx 6505 28 supernatant supernatant NN cord-010092-uftc8inx 6505 29 using use VBG cord-010092-uftc8inx 6505 30 CompoMat CompoMat NNP cord-010092-uftc8inx 6505 31 G5 G5 NNP cord-010092-uftc8inx 6505 32 extractor extractor NN cord-010092-uftc8inx 6505 33 . . . cord-010092-uftc8inx 6506 1 Wash wash VB cord-010092-uftc8inx 6506 2 procedure procedure NN cord-010092-uftc8inx 6506 3 was be VBD cord-010092-uftc8inx 6506 4 repeated repeat VBN cord-010092-uftc8inx 6506 5 twice twice RB cord-010092-uftc8inx 6506 6 using use VBG cord-010092-uftc8inx 6506 7 450 450 CD cord-010092-uftc8inx 6506 8 mL ml NN cord-010092-uftc8inx 6506 9 SAGM sagm NN cord-010092-uftc8inx 6506 10 solution solution NN cord-010092-uftc8inx 6506 11 , , , cord-010092-uftc8inx 6506 12 and and CC cord-010092-uftc8inx 6506 13 after after IN cord-010092-uftc8inx 6506 14 removal removal NN cord-010092-uftc8inx 6506 15 of of IN cord-010092-uftc8inx 6506 16 the the DT cord-010092-uftc8inx 6506 17 last last JJ cord-010092-uftc8inx 6506 18 supernatant supernatant NN cord-010092-uftc8inx 6506 19 , , , cord-010092-uftc8inx 6506 20 100 100 CD cord-010092-uftc8inx 6506 21 mL mL NNS cord-010092-uftc8inx 6506 22 of of IN cord-010092-uftc8inx 6506 23 SAGM SAGM NNP cord-010092-uftc8inx 6506 24 solution solution NN cord-010092-uftc8inx 6506 25 was be VBD cord-010092-uftc8inx 6506 26 added add VBN cord-010092-uftc8inx 6506 27 . . . cord-010092-uftc8inx 6507 1 All all DT cord-010092-uftc8inx 6507 2 units unit NNS cord-010092-uftc8inx 6507 3 were be VBD cord-010092-uftc8inx 6507 4 immediately immediately RB cord-010092-uftc8inx 6507 5 measured measure VBN cord-010092-uftc8inx 6507 6 for for IN cord-010092-uftc8inx 6507 7 volume volume NN cord-010092-uftc8inx 6507 8 , , , cord-010092-uftc8inx 6507 9 haematocrit haematocrit NNP cord-010092-uftc8inx 6507 10 , , , cord-010092-uftc8inx 6507 11 albumin albumin NN cord-010092-uftc8inx 6507 12 , , , cord-010092-uftc8inx 6507 13 IgA IgA NNP cord-010092-uftc8inx 6507 14 , , , cord-010092-uftc8inx 6507 15 potassium potassium NN cord-010092-uftc8inx 6507 16 , , , cord-010092-uftc8inx 6507 17 haemolysis haemolysis NN cord-010092-uftc8inx 6507 18 , , , cord-010092-uftc8inx 6507 19 haemoglobin haemoglobin NN cord-010092-uftc8inx 6507 20 , , , cord-010092-uftc8inx 6507 21 pH ph NN cord-010092-uftc8inx 6507 22 , , , cord-010092-uftc8inx 6507 23 glucose glucose NN cord-010092-uftc8inx 6507 24 and and CC cord-010092-uftc8inx 6507 25 lactate lactate NN cord-010092-uftc8inx 6507 26 and and CC cord-010092-uftc8inx 6507 27 tested test VBD cord-010092-uftc8inx 6507 28 again again RB cord-010092-uftc8inx 6507 29 after after IN cord-010092-uftc8inx 6507 30 24 24 CD cord-010092-uftc8inx 6507 31 h h NN cord-010092-uftc8inx 6507 32 , , , cord-010092-uftc8inx 6507 33 7 7 CD cord-010092-uftc8inx 6507 34 days day NNS cord-010092-uftc8inx 6507 35 and and CC cord-010092-uftc8inx 6507 36 14 14 CD cord-010092-uftc8inx 6507 37 days day NNS cord-010092-uftc8inx 6507 38 storage storage NN cord-010092-uftc8inx 6507 39 at at IN cord-010092-uftc8inx 6507 40 4 4 CD cord-010092-uftc8inx 6507 41 AE AE NNP cord-010092-uftc8inx 6507 42 2 2 CD cord-010092-uftc8inx 6507 43 ° ° NN cord-010092-uftc8inx 6507 44 C c NN cord-010092-uftc8inx 6507 45 . . . cord-010092-uftc8inx 6508 1 Results result NNS cord-010092-uftc8inx 6508 2 : : : cord-010092-uftc8inx 6509 1 All all DT cord-010092-uftc8inx 6509 2 washed wash VBN cord-010092-uftc8inx 6509 3 LD LD NNP cord-010092-uftc8inx 6509 4 - - HYPH cord-010092-uftc8inx 6509 5 RBCs rbc NNS cord-010092-uftc8inx 6509 6 met meet VBD cord-010092-uftc8inx 6509 7 European european JJ cord-010092-uftc8inx 6509 8 specification specification NN cord-010092-uftc8inx 6509 9 for for IN cord-010092-uftc8inx 6509 10 haematocrit haematocrit NNP cord-010092-uftc8inx 6509 11 ( ( -LRB- cord-010092-uftc8inx 6509 12 0.50 0.50 CD cord-010092-uftc8inx 6509 13 - - SYM cord-010092-uftc8inx 6509 14 0.70 0.70 CD cord-010092-uftc8inx 6509 15 ) ) -RRB- cord-010092-uftc8inx 6509 16 and and CC cord-010092-uftc8inx 6509 17 all all DT cord-010092-uftc8inx 6509 18 but but IN cord-010092-uftc8inx 6509 19 one one CD cord-010092-uftc8inx 6509 20 for for IN cord-010092-uftc8inx 6509 21 Hb Hb NNP cord-010092-uftc8inx 6509 22 content content NN cord-010092-uftc8inx 6509 23 ( ( -LRB- cord-010092-uftc8inx 6509 24 ≥ ≥ CD cord-010092-uftc8inx 6509 25 40 40 CD cord-010092-uftc8inx 6509 26 g g NN cord-010092-uftc8inx 6509 27 / / SYM cord-010092-uftc8inx 6509 28 unit unit NN cord-010092-uftc8inx 6509 29 ) ) -RRB- cord-010092-uftc8inx 6509 30 . . . cord-010092-uftc8inx 6510 1 Hemolysis Hemolysis NNP cord-010092-uftc8inx 6510 2 increased increase VBD cord-010092-uftc8inx 6510 3 during during IN cord-010092-uftc8inx 6510 4 storage storage NN cord-010092-uftc8inx 6510 5 . . . cord-010092-uftc8inx 6511 1 The the DT cord-010092-uftc8inx 6511 2 rate rate NN cord-010092-uftc8inx 6511 3 of of IN cord-010092-uftc8inx 6511 4 hemolysis hemolysis NN cord-010092-uftc8inx 6511 5 in in IN cord-010092-uftc8inx 6511 6 irradiated irradiate VBN cord-010092-uftc8inx 6511 7 LD LD NNP cord-010092-uftc8inx 6511 8 - - HYPH cord-010092-uftc8inx 6511 9 RBCS RBCS NNP cord-010092-uftc8inx 6511 10 was be VBD cord-010092-uftc8inx 6511 11 greater great JJR cord-010092-uftc8inx 6511 12 over over IN cord-010092-uftc8inx 6511 13 time time NN cord-010092-uftc8inx 6511 14 than than IN cord-010092-uftc8inx 6511 15 in in IN cord-010092-uftc8inx 6511 16 nonirradiated nonirradiate VBN cord-010092-uftc8inx 6511 17 units unit NNS cord-010092-uftc8inx 6511 18 . . . cord-010092-uftc8inx 6512 1 All all DT cord-010092-uftc8inx 6512 2 units unit NNS cord-010092-uftc8inx 6512 3 , , , cord-010092-uftc8inx 6512 4 both both CC cord-010092-uftc8inx 6512 5 irradiated irradiate VBD cord-010092-uftc8inx 6512 6 and and CC cord-010092-uftc8inx 6512 7 nonirradiated nonirradiate VBD cord-010092-uftc8inx 6512 8 , , , cord-010092-uftc8inx 6512 9 met meet VBD cord-010092-uftc8inx 6512 10 European european JJ cord-010092-uftc8inx 6512 11 specification specification NN cord-010092-uftc8inx 6512 12 for for IN cord-010092-uftc8inx 6512 13 hemolysis hemolysis NN cord-010092-uftc8inx 6512 14 ( ( -LRB- cord-010092-uftc8inx 6512 15 less less JJR cord-010092-uftc8inx 6512 16 than than IN cord-010092-uftc8inx 6512 17 0.8 0.8 CD cord-010092-uftc8inx 6512 18 % % NN cord-010092-uftc8inx 6512 19 ) ) -RRB- cord-010092-uftc8inx 6512 20 14 14 CD cord-010092-uftc8inx 6512 21 days day NNS cord-010092-uftc8inx 6512 22 after after IN cord-010092-uftc8inx 6512 23 washing wash VBG cord-010092-uftc8inx 6512 24 . . . cord-010092-uftc8inx 6513 1 After after IN cord-010092-uftc8inx 6513 2 wash wash NN cord-010092-uftc8inx 6513 3 , , , cord-010092-uftc8inx 6513 4 potassium potassium NN cord-010092-uftc8inx 6513 5 levels level NNS cord-010092-uftc8inx 6513 6 were be VBD cord-010092-uftc8inx 6513 7 low low JJ cord-010092-uftc8inx 6513 8 and and CC cord-010092-uftc8inx 6513 9 then then RB cord-010092-uftc8inx 6513 10 increased increase VBD cord-010092-uftc8inx 6513 11 during during IN cord-010092-uftc8inx 6513 12 storage storage NN cord-010092-uftc8inx 6513 13 ; ; : cord-010092-uftc8inx 6513 14 increase increase NN cord-010092-uftc8inx 6513 15 was be VBD cord-010092-uftc8inx 6513 16 greater great JJR cord-010092-uftc8inx 6513 17 in in IN cord-010092-uftc8inx 6513 18 irradiated irradiate VBN cord-010092-uftc8inx 6513 19 than than IN cord-010092-uftc8inx 6513 20 nonirradiated nonirradiate VBN cord-010092-uftc8inx 6513 21 units unit NNS cord-010092-uftc8inx 6513 22 . . . cord-010092-uftc8inx 6514 1 Potassium potassium NN cord-010092-uftc8inx 6514 2 concentration concentration NN cord-010092-uftc8inx 6514 3 14 14 CD cord-010092-uftc8inx 6514 4 days day NNS cord-010092-uftc8inx 6514 5 after after IN cord-010092-uftc8inx 6514 6 washing washing NN cord-010092-uftc8inx 6514 7 and and CC cord-010092-uftc8inx 6514 8 irradiation irradiation NN cord-010092-uftc8inx 6514 9 did do VBD cord-010092-uftc8inx 6514 10 not not RB cord-010092-uftc8inx 6514 11 exceed exceed VB cord-010092-uftc8inx 6514 12 those those DT cord-010092-uftc8inx 6514 13 levels level NNS cord-010092-uftc8inx 6514 14 found find VBN cord-010092-uftc8inx 6514 15 at at IN cord-010092-uftc8inx 6514 16 the the DT cord-010092-uftc8inx 6514 17 end end NN cord-010092-uftc8inx 6514 18 of of IN cord-010092-uftc8inx 6514 19 shelf shelf NN cord-010092-uftc8inx 6514 20 life life NN cord-010092-uftc8inx 6514 21 ( ( -LRB- cord-010092-uftc8inx 6514 22 day day NN cord-010092-uftc8inx 6514 23 35 35 CD cord-010092-uftc8inx 6514 24 ) ) -RRB- cord-010092-uftc8inx 6514 25 of of IN cord-010092-uftc8inx 6514 26 standard standard JJ cord-010092-uftc8inx 6514 27 LD LD NNP cord-010092-uftc8inx 6514 28 - - HYPH cord-010092-uftc8inx 6514 29 RBCs rbc NNS cord-010092-uftc8inx 6514 30 . . . cord-010092-uftc8inx 6515 1 pH pH NNP cord-010092-uftc8inx 6515 2 decreased decrease VBD cord-010092-uftc8inx 6515 3 during during IN cord-010092-uftc8inx 6515 4 storage storage NN cord-010092-uftc8inx 6515 5 due due IN cord-010092-uftc8inx 6515 6 to to IN cord-010092-uftc8inx 6515 7 the the DT cord-010092-uftc8inx 6515 8 metabolic metabolic JJ cord-010092-uftc8inx 6515 9 activity activity NN cord-010092-uftc8inx 6515 10 of of IN cord-010092-uftc8inx 6515 11 red red JJ cord-010092-uftc8inx 6515 12 blood blood NN cord-010092-uftc8inx 6515 13 cells cell NNS cord-010092-uftc8inx 6515 14 converting convert VBG cord-010092-uftc8inx 6515 15 glucose glucose NN cord-010092-uftc8inx 6515 16 to to IN cord-010092-uftc8inx 6515 17 lactate lactate NN cord-010092-uftc8inx 6515 18 . . . cord-010092-uftc8inx 6516 1 The the DT cord-010092-uftc8inx 6516 2 pH pH NNP cord-010092-uftc8inx 6516 3 level level NN cord-010092-uftc8inx 6516 4 of of IN cord-010092-uftc8inx 6516 5 the the DT cord-010092-uftc8inx 6516 6 supernatant supernatant NN cord-010092-uftc8inx 6516 7 depends depend VBZ cord-010092-uftc8inx 6516 8 on on IN cord-010092-uftc8inx 6516 9 the the DT cord-010092-uftc8inx 6516 10 age age NN cord-010092-uftc8inx 6516 11 of of IN cord-010092-uftc8inx 6516 12 the the DT cord-010092-uftc8inx 6516 13 unit unit NN cord-010092-uftc8inx 6516 14 and and CC cord-010092-uftc8inx 6516 15 not not RB cord-010092-uftc8inx 6516 16 on on IN cord-010092-uftc8inx 6516 17 the the DT cord-010092-uftc8inx 6516 18 irradiation irradiation NN cord-010092-uftc8inx 6516 19 . . . cord-010092-uftc8inx 6517 1 The the DT cord-010092-uftc8inx 6517 2 glucose glucose NN cord-010092-uftc8inx 6517 3 concentration concentration NN cord-010092-uftc8inx 6517 4 of of IN cord-010092-uftc8inx 6517 5 the the DT cord-010092-uftc8inx 6517 6 supernatant supernatant NN cord-010092-uftc8inx 6517 7 after after IN cord-010092-uftc8inx 6517 8 washing washing NN cord-010092-uftc8inx 6517 9 is be VBZ cord-010092-uftc8inx 6517 10 high high JJ cord-010092-uftc8inx 6517 11 due due IN cord-010092-uftc8inx 6517 12 to to IN cord-010092-uftc8inx 6517 13 SAGM SAGM NNP cord-010092-uftc8inx 6517 14 solution solution NN cord-010092-uftc8inx 6517 15 . . . cord-010092-uftc8inx 6518 1 The the DT cord-010092-uftc8inx 6518 2 concentration concentration NN cord-010092-uftc8inx 6518 3 of of IN cord-010092-uftc8inx 6518 4 glucose glucose NN cord-010092-uftc8inx 6518 5 decreased decrease VBD cord-010092-uftc8inx 6518 6 and and CC cord-010092-uftc8inx 6518 7 lactate lactate NN cord-010092-uftc8inx 6518 8 increased increase VBD cord-010092-uftc8inx 6518 9 due due IN cord-010092-uftc8inx 6518 10 to to IN cord-010092-uftc8inx 6518 11 the the DT cord-010092-uftc8inx 6518 12 metabolic metabolic JJ cord-010092-uftc8inx 6518 13 activity activity NN cord-010092-uftc8inx 6518 14 of of IN cord-010092-uftc8inx 6518 15 red red JJ cord-010092-uftc8inx 6518 16 blood blood NN cord-010092-uftc8inx 6518 17 cells cell NNS cord-010092-uftc8inx 6518 18 . . . cord-010092-uftc8inx 6519 1 There there EX cord-010092-uftc8inx 6519 2 is be VBZ cord-010092-uftc8inx 6519 3 currently currently RB cord-010092-uftc8inx 6519 4 no no DT cord-010092-uftc8inx 6519 5 specification specification NN cord-010092-uftc8inx 6519 6 in in IN cord-010092-uftc8inx 6519 7 Europe Europe NNP cord-010092-uftc8inx 6519 8 or or CC cord-010092-uftc8inx 6519 9 Finland Finland NNP cord-010092-uftc8inx 6519 10 for for IN cord-010092-uftc8inx 6519 11 IgA IgA NNP cord-010092-uftc8inx 6519 12 in in IN cord-010092-uftc8inx 6519 13 washed washed JJ cord-010092-uftc8inx 6519 14 RBCs rbc NNS cord-010092-uftc8inx 6519 15 . . . cord-010092-uftc8inx 6520 1 AABB AABB NNP cord-010092-uftc8inx 6520 2 and and CC cord-010092-uftc8inx 6520 3 American American NNP cord-010092-uftc8inx 6520 4 Red Red NNP cord-010092-uftc8inx 6520 5 Cross Cross NNP cord-010092-uftc8inx 6520 6 Rare Rare NNP cord-010092-uftc8inx 6520 7 Donor Donor NNP cord-010092-uftc8inx 6520 8 Program Program NNP cord-010092-uftc8inx 6520 9 stipulate stipulate VBP cord-010092-uftc8inx 6520 10 that that DT cord-010092-uftc8inx 6520 11 level level NN cord-010092-uftc8inx 6520 12 of of IN cord-010092-uftc8inx 6520 13 IgA IgA NNP cord-010092-uftc8inx 6520 14 should should MD cord-010092-uftc8inx 6520 15 be be VB cord-010092-uftc8inx 6520 16 less less JJR cord-010092-uftc8inx 6520 17 than than IN cord-010092-uftc8inx 6520 18 0.05 0.05 CD cord-010092-uftc8inx 6520 19 mg mg NN cord-010092-uftc8inx 6520 20 / / SYM cord-010092-uftc8inx 6520 21 dL dl NN cord-010092-uftc8inx 6520 22 ( ( -LRB- cord-010092-uftc8inx 6520 23 0.5 0.5 CD cord-010092-uftc8inx 6520 24 mg mg NNP cord-010092-uftc8inx 6520 25 / / SYM cord-010092-uftc8inx 6520 26 L L NNP cord-010092-uftc8inx 6520 27 ) ) -RRB- cord-010092-uftc8inx 6520 28 . . . cord-010092-uftc8inx 6521 1 Our -PRON- PRP$ cord-010092-uftc8inx 6521 2 IgA iga NN cord-010092-uftc8inx 6521 3 method method NN cord-010092-uftc8inx 6521 4 0 0 NFP cord-010092-uftc8inx 6521 5 s s POS cord-010092-uftc8inx 6521 6 lower low JJR cord-010092-uftc8inx 6521 7 limit limit NN cord-010092-uftc8inx 6521 8 for for IN cord-010092-uftc8inx 6521 9 detection detection NN cord-010092-uftc8inx 6521 10 is be VBZ cord-010092-uftc8inx 6521 11 0.05 0.05 CD cord-010092-uftc8inx 6521 12 mg mg NNP cord-010092-uftc8inx 6521 13 / / SYM cord-010092-uftc8inx 6521 14 L L NNP cord-010092-uftc8inx 6521 15 and and CC cord-010092-uftc8inx 6521 16 all all DT cord-010092-uftc8inx 6521 17 results result NNS cord-010092-uftc8inx 6522 1 were be VBD cord-010092-uftc8inx 6522 2 below below IN cord-010092-uftc8inx 6522 3 this this DT cord-010092-uftc8inx 6522 4 level level NN cord-010092-uftc8inx 6522 5 . . . cord-010092-uftc8inx 6523 1 Total total JJ cord-010092-uftc8inx 6523 2 albumin albumin NN cord-010092-uftc8inx 6523 3 were be VBD cord-010092-uftc8inx 6523 4 well well RB cord-010092-uftc8inx 6523 5 below below IN cord-010092-uftc8inx 6523 6 Finnish finnish JJ cord-010092-uftc8inx 6523 7 specification specification NN cord-010092-uftc8inx 6523 8 ( ( -LRB- cord-010092-uftc8inx 6523 9 < < NNP cord-010092-uftc8inx 6523 10 250 250 CD cord-010092-uftc8inx 6523 11 mg mg NNP cord-010092-uftc8inx 6523 12 / / SYM cord-010092-uftc8inx 6523 13 unit unit NN cord-010092-uftc8inx 6523 14 ) ) -RRB- cord-010092-uftc8inx 6523 15 . . . cord-010092-uftc8inx 6524 1 Background background NN cord-010092-uftc8inx 6524 2 : : : cord-010092-uftc8inx 6525 1 Room room NN cord-010092-uftc8inx 6525 2 temperature temperature NN cord-010092-uftc8inx 6525 3 has have VBZ cord-010092-uftc8inx 6525 4 been be VBN cord-010092-uftc8inx 6525 5 the the DT cord-010092-uftc8inx 6525 6 standard standard JJ cord-010092-uftc8inx 6525 7 storage storage NN cord-010092-uftc8inx 6525 8 condition condition NN cord-010092-uftc8inx 6525 9 for for IN cord-010092-uftc8inx 6525 10 platelets platelet NNS cord-010092-uftc8inx 6525 11 since since IN cord-010092-uftc8inx 6525 12 the the DT cord-010092-uftc8inx 6525 13 1970s 1970 NNS cord-010092-uftc8inx 6525 14 , , , cord-010092-uftc8inx 6525 15 when when WRB cord-010092-uftc8inx 6525 16 it -PRON- PRP cord-010092-uftc8inx 6525 17 was be VBD cord-010092-uftc8inx 6525 18 shown show VBN cord-010092-uftc8inx 6525 19 that that IN cord-010092-uftc8inx 6525 20 this this DT cord-010092-uftc8inx 6525 21 improved improve VBD cord-010092-uftc8inx 6525 22 in in IN cord-010092-uftc8inx 6525 23 vivo vivo NN cord-010092-uftc8inx 6525 24 survival survival NN cord-010092-uftc8inx 6525 25 compared compare VBN cord-010092-uftc8inx 6525 26 to to IN cord-010092-uftc8inx 6525 27 when when WRB cord-010092-uftc8inx 6525 28 stored store VBN cord-010092-uftc8inx 6525 29 at at IN cord-010092-uftc8inx 6525 30 4 4 CD cord-010092-uftc8inx 6525 31 ° ° NN cord-010092-uftc8inx 6525 32 C c NN cord-010092-uftc8inx 6525 33 . . . cord-010092-uftc8inx 6526 1 However however RB cord-010092-uftc8inx 6526 2 , , , cord-010092-uftc8inx 6526 3 storage storage NN cord-010092-uftc8inx 6526 4 at at IN cord-010092-uftc8inx 6526 5 room room NN cord-010092-uftc8inx 6526 6 temperature temperature NN cord-010092-uftc8inx 6526 7 has have VBZ cord-010092-uftc8inx 6526 8 several several JJ cord-010092-uftc8inx 6526 9 disadvantages disadvantage NNS cord-010092-uftc8inx 6526 10 , , , cord-010092-uftc8inx 6526 11 including include VBG cord-010092-uftc8inx 6526 12 risk risk NN cord-010092-uftc8inx 6526 13 for for IN cord-010092-uftc8inx 6526 14 bacterial bacterial JJ cord-010092-uftc8inx 6526 15 contamination contamination NN cord-010092-uftc8inx 6526 16 and and CC cord-010092-uftc8inx 6526 17 short short JJ cord-010092-uftc8inx 6526 18 outdating outdating NN cord-010092-uftc8inx 6526 19 . . . cord-010092-uftc8inx 6527 1 Recently recently RB cord-010092-uftc8inx 6527 2 , , , cord-010092-uftc8inx 6527 3 the the DT cord-010092-uftc8inx 6527 4 interest interest NN cord-010092-uftc8inx 6527 5 in in IN cord-010092-uftc8inx 6527 6 cold cold JJ cord-010092-uftc8inx 6527 7 - - HYPH cord-010092-uftc8inx 6527 8 stored store VBN cord-010092-uftc8inx 6527 9 platelets platelet NNS cord-010092-uftc8inx 6527 10 increased increase VBD cord-010092-uftc8inx 6527 11 , , , cord-010092-uftc8inx 6527 12 especially especially RB cord-010092-uftc8inx 6527 13 for for IN cord-010092-uftc8inx 6527 14 patients patient NNS cord-010092-uftc8inx 6527 15 with with IN cord-010092-uftc8inx 6527 16 a a DT cord-010092-uftc8inx 6527 17 hemostatic hemostatic JJ cord-010092-uftc8inx 6527 18 need need NN cord-010092-uftc8inx 6527 19 . . . cord-010092-uftc8inx 6528 1 Using use VBG cord-010092-uftc8inx 6528 2 extensive extensive JJ cord-010092-uftc8inx 6528 3 analysis analysis NN cord-010092-uftc8inx 6528 4 techniques technique NNS cord-010092-uftc8inx 6528 5 , , , cord-010092-uftc8inx 6528 6 we -PRON- PRP cord-010092-uftc8inx 6528 7 evaluated evaluate VBD cord-010092-uftc8inx 6528 8 the the DT cord-010092-uftc8inx 6528 9 in in FW cord-010092-uftc8inx 6528 10 vitro vitro FW cord-010092-uftc8inx 6528 11 quality quality NN cord-010092-uftc8inx 6528 12 of of IN cord-010092-uftc8inx 6528 13 cold cold JJ cord-010092-uftc8inx 6528 14 stored store VBN cord-010092-uftc8inx 6528 15 platelets platelet NNS cord-010092-uftc8inx 6528 16 in in IN cord-010092-uftc8inx 6528 17 additive additive NN cord-010092-uftc8inx 6528 18 solution solution NN cord-010092-uftc8inx 6528 19 . . . cord-010092-uftc8inx 6529 1 Aims aim VBZ cord-010092-uftc8inx 6529 2 : : : cord-010092-uftc8inx 6529 3 Investigation investigation NN cord-010092-uftc8inx 6529 4 of of IN cord-010092-uftc8inx 6529 5 the the DT cord-010092-uftc8inx 6529 6 in in FW cord-010092-uftc8inx 6529 7 vitro vitro FW cord-010092-uftc8inx 6529 8 quality quality NN cord-010092-uftc8inx 6529 9 of of IN cord-010092-uftc8inx 6529 10 platelets platelet NNS cord-010092-uftc8inx 6529 11 stored store VBN cord-010092-uftc8inx 6529 12 at at IN cord-010092-uftc8inx 6529 13 4 4 CD cord-010092-uftc8inx 6529 14 - - SYM cord-010092-uftc8inx 6529 15 9 9 CD cord-010092-uftc8inx 6529 16 ° ° NN cord-010092-uftc8inx 6529 17 C c NN cord-010092-uftc8inx 6529 18 in in IN cord-010092-uftc8inx 6529 19 PAS pas NN cord-010092-uftc8inx 6529 20 - - HYPH cord-010092-uftc8inx 6529 21 E. E. NNP cord-010092-uftc8inx 6529 22 Methods method NNS cord-010092-uftc8inx 6529 23 : : : cord-010092-uftc8inx 6529 24 Three three CD cord-010092-uftc8inx 6529 25 experiments experiment NNS cord-010092-uftc8inx 6529 26 were be VBD cord-010092-uftc8inx 6529 27 performed perform VBN cord-010092-uftc8inx 6529 28 , , , cord-010092-uftc8inx 6529 29 in in IN cord-010092-uftc8inx 6529 30 which which WDT cord-010092-uftc8inx 6529 31 two two CD cord-010092-uftc8inx 6529 32 platelet platelet NN cord-010092-uftc8inx 6529 33 concentrates concentrate VBZ cord-010092-uftc8inx 6529 34 , , , cord-010092-uftc8inx 6529 35 prepared prepare VBN cord-010092-uftc8inx 6529 36 from from IN cord-010092-uftc8inx 6529 37 5 5 CD cord-010092-uftc8inx 6529 38 buffy buffy NNP cord-010092-uftc8inx 6529 39 coats coat NNS cord-010092-uftc8inx 6529 40 and and CC cord-010092-uftc8inx 6529 41 300 300 CD cord-010092-uftc8inx 6529 42 mL ml NN cord-010092-uftc8inx 6529 43 of of IN cord-010092-uftc8inx 6529 44 PAS pas NN cord-010092-uftc8inx 6529 45 - - HYPH cord-010092-uftc8inx 6529 46 E e NN cord-010092-uftc8inx 6529 47 ( ( -LRB- cord-010092-uftc8inx 6529 48 PCs pc NNS cord-010092-uftc8inx 6529 49 ) ) -RRB- cord-010092-uftc8inx 6529 50 were be VBD cord-010092-uftc8inx 6529 51 pooled pool VBN cord-010092-uftc8inx 6529 52 and and CC cord-010092-uftc8inx 6529 53 split split VBD cord-010092-uftc8inx 6529 54 in in IN cord-010092-uftc8inx 6529 55 equal equal JJ cord-010092-uftc8inx 6529 56 PCs pc NNS cord-010092-uftc8inx 6529 57 . . . cord-010092-uftc8inx 6530 1 PCs pc NNS cord-010092-uftc8inx 6530 2 were be VBD cord-010092-uftc8inx 6530 3 stored store VBN cord-010092-uftc8inx 6530 4 for for IN cord-010092-uftc8inx 6530 5 23 23 CD cord-010092-uftc8inx 6530 6 days day NNS cord-010092-uftc8inx 6530 7 at at IN cord-010092-uftc8inx 6530 8 4 4 CD cord-010092-uftc8inx 6530 9 - - SYM cord-010092-uftc8inx 6530 10 9 9 CD cord-010092-uftc8inx 6530 11 ° ° NN cord-010092-uftc8inx 6530 12 C c NN cord-010092-uftc8inx 6530 13 , , , cord-010092-uftc8inx 6530 14 one one CD cord-010092-uftc8inx 6530 15 of of IN cord-010092-uftc8inx 6530 16 each each DT cord-010092-uftc8inx 6530 17 pair pair NN cord-010092-uftc8inx 6530 18 with with IN cord-010092-uftc8inx 6530 19 agitation agitation NN cord-010092-uftc8inx 6530 20 on on IN cord-010092-uftc8inx 6530 21 a a DT cord-010092-uftc8inx 6530 22 flatbed flatbed NN cord-010092-uftc8inx 6530 23 shaker shaker NN cord-010092-uftc8inx 6530 24 and and CC cord-010092-uftc8inx 6530 25 the the DT cord-010092-uftc8inx 6530 26 other other JJ cord-010092-uftc8inx 6530 27 without without IN cord-010092-uftc8inx 6530 28 agitation agitation NN cord-010092-uftc8inx 6530 29 . . . cord-010092-uftc8inx 6531 1 Various various JJ cord-010092-uftc8inx 6531 2 parameters parameter NNS cord-010092-uftc8inx 6531 3 were be VBD cord-010092-uftc8inx 6531 4 analyzed analyze VBN cord-010092-uftc8inx 6531 5 to to TO cord-010092-uftc8inx 6531 6 study study VB cord-010092-uftc8inx 6531 7 the the DT cord-010092-uftc8inx 6531 8 in in FW cord-010092-uftc8inx 6531 9 vitro vitro FW cord-010092-uftc8inx 6531 10 quality quality NN cord-010092-uftc8inx 6531 11 during during IN cord-010092-uftc8inx 6531 12 storage storage NN cord-010092-uftc8inx 6531 13 and and CC cord-010092-uftc8inx 6531 14 compared compare VBN cord-010092-uftc8inx 6531 15 to to IN cord-010092-uftc8inx 6531 16 routine routine JJ cord-010092-uftc8inx 6531 17 room room NN cord-010092-uftc8inx 6531 18 temperature temperature NN cord-010092-uftc8inx 6531 19 storage storage NN cord-010092-uftc8inx 6531 20 . . . cord-010092-uftc8inx 6532 1 Results result NNS cord-010092-uftc8inx 6532 2 : : : cord-010092-uftc8inx 6533 1 During during IN cord-010092-uftc8inx 6533 2 cold cold JJ cord-010092-uftc8inx 6533 3 storage storage NN cord-010092-uftc8inx 6533 4 , , , cord-010092-uftc8inx 6533 5 the the DT cord-010092-uftc8inx 6533 6 swirling swirl VBG cord-010092-uftc8inx 6533 7 phenomenon phenomenon NN cord-010092-uftc8inx 6533 8 disappeared disappear VBD cord-010092-uftc8inx 6533 9 within within IN cord-010092-uftc8inx 6533 10 one one CD cord-010092-uftc8inx 6533 11 day day NN cord-010092-uftc8inx 6533 12 . . . cord-010092-uftc8inx 6534 1 Due due IN cord-010092-uftc8inx 6534 2 to to IN cord-010092-uftc8inx 6534 3 the the DT cord-010092-uftc8inx 6534 4 lower low JJR cord-010092-uftc8inx 6534 5 temperature temperature NN cord-010092-uftc8inx 6534 6 , , , cord-010092-uftc8inx 6534 7 metabolism metabolism NN cord-010092-uftc8inx 6534 8 of of IN cord-010092-uftc8inx 6534 9 the the DT cord-010092-uftc8inx 6534 10 platelets platelet NNS cord-010092-uftc8inx 6534 11 was be VBD cord-010092-uftc8inx 6534 12 lower low JJR cord-010092-uftc8inx 6534 13 as as IN cord-010092-uftc8inx 6534 14 compared compare VBN cord-010092-uftc8inx 6534 15 to to IN cord-010092-uftc8inx 6534 16 room room NN cord-010092-uftc8inx 6534 17 temperature temperature NN cord-010092-uftc8inx 6534 18 storage storage NN cord-010092-uftc8inx 6534 19 . . . cord-010092-uftc8inx 6535 1 The the DT cord-010092-uftc8inx 6535 2 metabolic metabolic JJ cord-010092-uftc8inx 6535 3 conditions condition NNS cord-010092-uftc8inx 6535 4 were be VBD cord-010092-uftc8inx 6535 5 acceptable acceptable JJ cord-010092-uftc8inx 6535 6 with with IN cord-010092-uftc8inx 6535 7 pH pH NNP cord-010092-uftc8inx 6535 8 d1-d16 d1-d16 NNP cord-010092-uftc8inx 6535 9 : : : cord-010092-uftc8inx 6535 10 7.05 7.05 CD cord-010092-uftc8inx 6535 11 - - HYPH cord-010092-uftc8inx 6535 12 6.77 6.77 CD cord-010092-uftc8inx 6535 13 with with IN cord-010092-uftc8inx 6535 14 platelet platelet NN cord-010092-uftc8inx 6535 15 count count NN cord-010092-uftc8inx 6535 16 400 400 CD cord-010092-uftc8inx 6535 17 9 9 CD cord-010092-uftc8inx 6535 18 10 10 CD cord-010092-uftc8inx 6535 19 9 9 CD cord-010092-uftc8inx 6535 20 /U /U NNS cord-010092-uftc8inx 6535 21 and and CC cord-010092-uftc8inx 6535 22 glucose glucose NN cord-010092-uftc8inx 6535 23 still still RB cord-010092-uftc8inx 6535 24 at at IN cord-010092-uftc8inx 6535 25 2 2 CD cord-010092-uftc8inx 6535 26 mM mm CD cord-010092-uftc8inx 6535 27 at at RB cord-010092-uftc8inx 6535 28 least least JJS cord-010092-uftc8inx 6535 29 until until IN cord-010092-uftc8inx 6535 30 16 16 CD cord-010092-uftc8inx 6535 31 days day NNS cord-010092-uftc8inx 6535 32 of of IN cord-010092-uftc8inx 6535 33 storage storage NN cord-010092-uftc8inx 6535 34 . . . cord-010092-uftc8inx 6536 1 Platelet platelet NN cord-010092-uftc8inx 6536 2 activation activation NN cord-010092-uftc8inx 6536 3 maintained maintain VBD cord-010092-uftc8inx 6536 4 acceptable acceptable JJ cord-010092-uftc8inx 6536 5 levels level NNS cord-010092-uftc8inx 6536 6 with with IN cord-010092-uftc8inx 6536 7 CD62P cd62p NN cord-010092-uftc8inx 6536 8 expression expression NN cord-010092-uftc8inx 6536 9 < < XX cord-010092-uftc8inx 6536 10 30 30 CD cord-010092-uftc8inx 6536 11 % % NN cord-010092-uftc8inx 6536 12 , , , cord-010092-uftc8inx 6536 13 while while IN cord-010092-uftc8inx 6536 14 PS PS NNP cord-010092-uftc8inx 6536 15 exposure exposure NN cord-010092-uftc8inx 6536 16 increased increase VBD cord-010092-uftc8inx 6536 17 rapidly rapidly RB cord-010092-uftc8inx 6536 18 ; ; : cord-010092-uftc8inx 6536 19 > > XX cord-010092-uftc8inx 6536 20 20 20 CD cord-010092-uftc8inx 6536 21 % % NN cord-010092-uftc8inx 6536 22 after after IN cord-010092-uftc8inx 6536 23 6 6 CD cord-010092-uftc8inx 6536 24 days day NNS cord-010092-uftc8inx 6536 25 of of IN cord-010092-uftc8inx 6536 26 storage storage NN cord-010092-uftc8inx 6536 27 . . . cord-010092-uftc8inx 6537 1 Aggregation aggregation NN cord-010092-uftc8inx 6537 2 tests test NNS cord-010092-uftc8inx 6537 3 showed show VBD cord-010092-uftc8inx 6537 4 functional functional JJ cord-010092-uftc8inx 6537 5 platelets platelet NNS cord-010092-uftc8inx 6537 6 until until IN cord-010092-uftc8inx 6537 7 13 13 CD cord-010092-uftc8inx 6537 8 days day NNS cord-010092-uftc8inx 6537 9 of of IN cord-010092-uftc8inx 6537 10 storage storage NN cord-010092-uftc8inx 6537 11 . . . cord-010092-uftc8inx 6538 1 Agitation agitation NN cord-010092-uftc8inx 6538 2 during during IN cord-010092-uftc8inx 6538 3 storage storage NN cord-010092-uftc8inx 6538 4 had have VBD cord-010092-uftc8inx 6538 5 no no DT cord-010092-uftc8inx 6538 6 effect effect NN cord-010092-uftc8inx 6538 7 on on IN cord-010092-uftc8inx 6538 8 any any DT cord-010092-uftc8inx 6538 9 of of IN cord-010092-uftc8inx 6538 10 the the DT cord-010092-uftc8inx 6538 11 tested test VBN cord-010092-uftc8inx 6538 12 parameters parameter NNS cord-010092-uftc8inx 6538 13 . . . cord-010092-uftc8inx 6539 1 Summary Summary NNP cord-010092-uftc8inx 6539 2 / / SYM cord-010092-uftc8inx 6539 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 6539 4 : : : cord-010092-uftc8inx 6540 1 During during IN cord-010092-uftc8inx 6540 2 storage storage NN cord-010092-uftc8inx 6540 3 of of IN cord-010092-uftc8inx 6540 4 platelets platelet NNS cord-010092-uftc8inx 6540 5 at at IN cord-010092-uftc8inx 6540 6 4 4 CD cord-010092-uftc8inx 6540 7 - - SYM cord-010092-uftc8inx 6540 8 9 9 CD cord-010092-uftc8inx 6540 9 ° ° NN cord-010092-uftc8inx 6540 10 C c NN cord-010092-uftc8inx 6540 11 , , , cord-010092-uftc8inx 6540 12 the the DT cord-010092-uftc8inx 6540 13 hematological hematological JJ cord-010092-uftc8inx 6540 14 parameters parameter NNS cord-010092-uftc8inx 6540 15 and and CC cord-010092-uftc8inx 6540 16 pH pH NNP cord-010092-uftc8inx 6540 17 met meet VBD cord-010092-uftc8inx 6540 18 routine routine JJ cord-010092-uftc8inx 6540 19 requirements requirement NNS cord-010092-uftc8inx 6540 20 , , , cord-010092-uftc8inx 6540 21 while while IN cord-010092-uftc8inx 6540 22 swirling swirl VBG cord-010092-uftc8inx 6540 23 phenomenon phenomenon NN cord-010092-uftc8inx 6540 24 disappeared disappear VBD cord-010092-uftc8inx 6540 25 already already RB cord-010092-uftc8inx 6540 26 at at IN cord-010092-uftc8inx 6540 27 the the DT cord-010092-uftc8inx 6540 28 first first JJ cord-010092-uftc8inx 6540 29 day day NN cord-010092-uftc8inx 6540 30 . . . cord-010092-uftc8inx 6541 1 The the DT cord-010092-uftc8inx 6541 2 functionality functionality NN cord-010092-uftc8inx 6541 3 of of IN cord-010092-uftc8inx 6541 4 the the DT cord-010092-uftc8inx 6541 5 platelets platelet NNS cord-010092-uftc8inx 6541 6 did do VBD cord-010092-uftc8inx 6541 7 not not RB cord-010092-uftc8inx 6541 8 decrease decrease VB cord-010092-uftc8inx 6541 9 during during IN cord-010092-uftc8inx 6541 10 cold cold JJ cord-010092-uftc8inx 6541 11 storage storage NN cord-010092-uftc8inx 6541 12 , , , cord-010092-uftc8inx 6541 13 indicating indicate VBG cord-010092-uftc8inx 6541 14 that that IN cord-010092-uftc8inx 6541 15 the the DT cord-010092-uftc8inx 6541 16 swirling swirl VBG cord-010092-uftc8inx 6541 17 phenomenon phenomenon NN cord-010092-uftc8inx 6541 18 is be VBZ cord-010092-uftc8inx 6541 19 not not RB cord-010092-uftc8inx 6541 20 a a DT cord-010092-uftc8inx 6541 21 good good JJ cord-010092-uftc8inx 6541 22 surrogate surrogate JJ cord-010092-uftc8inx 6541 23 marker marker NN cord-010092-uftc8inx 6541 24 under under IN cord-010092-uftc8inx 6541 25 these these DT cord-010092-uftc8inx 6541 26 conditions condition NNS cord-010092-uftc8inx 6541 27 . . . cord-010092-uftc8inx 6542 1 The the DT cord-010092-uftc8inx 6542 2 strong strong JJ cord-010092-uftc8inx 6542 3 increase increase NN cord-010092-uftc8inx 6542 4 of of IN cord-010092-uftc8inx 6542 5 PS PS NNP cord-010092-uftc8inx 6542 6 exposure exposure NN cord-010092-uftc8inx 6542 7 might may MD cord-010092-uftc8inx 6542 8 be be VB cord-010092-uftc8inx 6542 9 involved involve VBN cord-010092-uftc8inx 6542 10 in in IN cord-010092-uftc8inx 6542 11 the the DT cord-010092-uftc8inx 6542 12 observed observed JJ cord-010092-uftc8inx 6542 13 short short JJ cord-010092-uftc8inx 6542 14 survival survival NN cord-010092-uftc8inx 6542 15 of of IN cord-010092-uftc8inx 6542 16 cold cold NN cord-010092-uftc8inx 6542 17 - - HYPH cord-010092-uftc8inx 6542 18 stored store VBN cord-010092-uftc8inx 6542 19 platelets platelet NNS cord-010092-uftc8inx 6542 20 . . . cord-010092-uftc8inx 6543 1 Platelet platelet NN cord-010092-uftc8inx 6543 2 concentrates concentrate VBZ cord-010092-uftc8inx 6543 3 stored store VBN cord-010092-uftc8inx 6543 4 at at IN cord-010092-uftc8inx 6543 5 4 4 CD cord-010092-uftc8inx 6543 6 - - SYM cord-010092-uftc8inx 6543 7 9 9 CD cord-010092-uftc8inx 6543 8 ° ° NN cord-010092-uftc8inx 6543 9 C c NN cord-010092-uftc8inx 6543 10 are be VBP cord-010092-uftc8inx 6543 11 potentially potentially RB cord-010092-uftc8inx 6543 12 suitable suitable JJ cord-010092-uftc8inx 6543 13 as as IN cord-010092-uftc8inx 6543 14 a a DT cord-010092-uftc8inx 6543 15 hemostatic hemostatic JJ cord-010092-uftc8inx 6543 16 agent agent NN cord-010092-uftc8inx 6543 17 for for IN cord-010092-uftc8inx 6543 18 patients patient NNS cord-010092-uftc8inx 6543 19 with with IN cord-010092-uftc8inx 6543 20 a a DT cord-010092-uftc8inx 6543 21 bleeding bleeding NN cord-010092-uftc8inx 6543 22 in in IN cord-010092-uftc8inx 6543 23 need need NN cord-010092-uftc8inx 6543 24 of of IN cord-010092-uftc8inx 6543 25 platelets platelet NNS cord-010092-uftc8inx 6543 26 , , , cord-010092-uftc8inx 6543 27 but but CC cord-010092-uftc8inx 6543 28 more more JJR cord-010092-uftc8inx 6543 29 studies study NNS cord-010092-uftc8inx 6543 30 are be VBP cord-010092-uftc8inx 6543 31 needed need VBN cord-010092-uftc8inx 6543 32 . . . cord-010092-uftc8inx 6544 1 Aims aim VBZ cord-010092-uftc8inx 6544 2 : : : cord-010092-uftc8inx 6545 1 The the DT cord-010092-uftc8inx 6545 2 goal goal NN cord-010092-uftc8inx 6545 3 of of IN cord-010092-uftc8inx 6545 4 the the DT cord-010092-uftc8inx 6545 5 study study NN cord-010092-uftc8inx 6545 6 is be VBZ cord-010092-uftc8inx 6545 7 the the DT cord-010092-uftc8inx 6545 8 reinforcement reinforcement NN cord-010092-uftc8inx 6545 9 of of IN cord-010092-uftc8inx 6545 10 platelet platelet NN cord-010092-uftc8inx 6545 11 reserves reserve NNS cord-010092-uftc8inx 6545 12 for for IN cord-010092-uftc8inx 6545 13 case case NN cord-010092-uftc8inx 6545 14 of of IN cord-010092-uftc8inx 6545 15 emergency emergency NN cord-010092-uftc8inx 6545 16 events event NNS cord-010092-uftc8inx 6545 17 and and CC cord-010092-uftc8inx 6545 18 increasing increase VBG cord-010092-uftc8inx 6545 19 their -PRON- PRP$ cord-010092-uftc8inx 6545 20 availability availability NN cord-010092-uftc8inx 6545 21 for for IN cord-010092-uftc8inx 6545 22 treatment treatment NN cord-010092-uftc8inx 6545 23 , , , cord-010092-uftc8inx 6545 24 preferentially preferentially RB cord-010092-uftc8inx 6545 25 in in IN cord-010092-uftc8inx 6545 26 patients patient NNS cord-010092-uftc8inx 6545 27 with with IN cord-010092-uftc8inx 6545 28 massive massive JJ cord-010092-uftc8inx 6545 29 bleeding bleeding NN cord-010092-uftc8inx 6545 30 . . . cord-010092-uftc8inx 6546 1 Methods method NNS cord-010092-uftc8inx 6546 2 : : : cord-010092-uftc8inx 6546 3 We -PRON- PRP cord-010092-uftc8inx 6546 4 performed perform VBD cord-010092-uftc8inx 6546 5 a a DT cord-010092-uftc8inx 6546 6 comparative comparative JJ cord-010092-uftc8inx 6546 7 study study NN cord-010092-uftc8inx 6546 8 with with IN cord-010092-uftc8inx 6546 9 CPP CPP NNP cord-010092-uftc8inx 6546 10 and and CC cord-010092-uftc8inx 6546 11 FP FP NNP cord-010092-uftc8inx 6546 12 in in IN cord-010092-uftc8inx 6546 13 vitro vitro FW cord-010092-uftc8inx 6546 14 . . . cord-010092-uftc8inx 6547 1 Buffy Buffy NNP cord-010092-uftc8inx 6547 2 coatderived coatderive VBD cord-010092-uftc8inx 6547 3 pooled pool VBD cord-010092-uftc8inx 6547 4 leukoreduced leukoreduced JJ cord-010092-uftc8inx 6547 5 platelets platelet NNS cord-010092-uftc8inx 6547 6 0 0 CD cord-010092-uftc8inx 6547 7 RhD rhd NN cord-010092-uftc8inx 6547 8 negative negative JJ cord-010092-uftc8inx 6547 9 were be VBD cord-010092-uftc8inx 6547 10 frozen freeze VBN cord-010092-uftc8inx 6547 11 in in IN cord-010092-uftc8inx 6547 12 5 5 CD cord-010092-uftc8inx 6547 13 - - SYM cord-010092-uftc8inx 6547 14 6 6 CD cord-010092-uftc8inx 6547 15 % % NN cord-010092-uftc8inx 6547 16 DMSO DMSO NNP cord-010092-uftc8inx 6547 17 and and CC cord-010092-uftc8inx 6547 18 stored store VBN cord-010092-uftc8inx 6547 19 at at IN cord-010092-uftc8inx 6547 20 À80 À80 NNP cord-010092-uftc8inx 6547 21 ° ° NN cord-010092-uftc8inx 6547 22 C c NN cord-010092-uftc8inx 6547 23 for for IN cord-010092-uftc8inx 6547 24 6 6 CD cord-010092-uftc8inx 6547 25 months month NNS cord-010092-uftc8inx 6547 26 . . . cord-010092-uftc8inx 6548 1 CPP CPP NNP cord-010092-uftc8inx 6548 2 were be VBD cord-010092-uftc8inx 6548 3 thawed thaw VBN cord-010092-uftc8inx 6548 4 at at IN cord-010092-uftc8inx 6548 5 37 37 CD cord-010092-uftc8inx 6548 6 ° ° NN cord-010092-uftc8inx 6548 7 C c NN cord-010092-uftc8inx 6548 8 , , , cord-010092-uftc8inx 6548 9 then then RB cord-010092-uftc8inx 6548 10 reconstituted reconstitute VBN cord-010092-uftc8inx 6548 11 in in IN cord-010092-uftc8inx 6548 12 platelet platelet NN cord-010092-uftc8inx 6548 13 additive additive NN cord-010092-uftc8inx 6548 14 solution solution NN cord-010092-uftc8inx 6548 15 SSP+ SSP+ NNP cord-010092-uftc8inx 6548 16 and and CC cord-010092-uftc8inx 6548 17 compared compare VBN cord-010092-uftc8inx 6548 18 to to IN cord-010092-uftc8inx 6548 19 FP FP NNP cord-010092-uftc8inx 6548 20 . . . cord-010092-uftc8inx 6549 1 We -PRON- PRP cord-010092-uftc8inx 6549 2 measured measure VBD cord-010092-uftc8inx 6549 3 these these DT cord-010092-uftc8inx 6549 4 parameters parameter NNS cord-010092-uftc8inx 6549 5 : : : cord-010092-uftc8inx 6549 6 platelet platelet NN cord-010092-uftc8inx 6549 7 content content NN cord-010092-uftc8inx 6549 8 , , , cord-010092-uftc8inx 6549 9 platelet platelet NN cord-010092-uftc8inx 6549 10 concentration concentration NN cord-010092-uftc8inx 6549 11 , , , cord-010092-uftc8inx 6549 12 platelet platelet NN cord-010092-uftc8inx 6549 13 loss loss NN cord-010092-uftc8inx 6549 14 during during IN cord-010092-uftc8inx 6549 15 preparation preparation NN cord-010092-uftc8inx 6549 16 process process NN cord-010092-uftc8inx 6549 17 , , , cord-010092-uftc8inx 6549 18 coagulation coagulation NN cord-010092-uftc8inx 6549 19 properties property NNS cord-010092-uftc8inx 6549 20 , , , cord-010092-uftc8inx 6549 21 volume volume NN cord-010092-uftc8inx 6549 22 , , , cord-010092-uftc8inx 6549 23 pH pH NNP cord-010092-uftc8inx 6549 24 , , , cord-010092-uftc8inx 6549 25 DMSO DMSO NNP cord-010092-uftc8inx 6549 26 concentration concentration NN cord-010092-uftc8inx 6549 27 , , , cord-010092-uftc8inx 6549 28 titres titre NNS cord-010092-uftc8inx 6549 29 of of IN cord-010092-uftc8inx 6549 30 anti anti JJ cord-010092-uftc8inx 6549 31 - - JJ cord-010092-uftc8inx 6549 32 A a JJ cord-010092-uftc8inx 6549 33 and and CC cord-010092-uftc8inx 6549 34 anti anti JJ cord-010092-uftc8inx 6549 35 - - JJ cord-010092-uftc8inx 6549 36 B b JJ cord-010092-uftc8inx 6549 37 antibodies antibody NNS cord-010092-uftc8inx 6549 38 . . . cord-010092-uftc8inx 6550 1 Results result NNS cord-010092-uftc8inx 6550 2 : : : cord-010092-uftc8inx 6551 1 The the DT cord-010092-uftc8inx 6551 2 average average JJ cord-010092-uftc8inx 6551 3 platelet platelet NN cord-010092-uftc8inx 6551 4 loss loss NN cord-010092-uftc8inx 6551 5 after after IN cord-010092-uftc8inx 6551 6 the the DT cord-010092-uftc8inx 6551 7 process process NN cord-010092-uftc8inx 6551 8 of of IN cord-010092-uftc8inx 6551 9 freezing freezing NN cord-010092-uftc8inx 6551 10 and and CC cord-010092-uftc8inx 6551 11 reconstitution reconstitution NN cord-010092-uftc8inx 6551 12 was be VBD cord-010092-uftc8inx 6551 13 24 24 CD cord-010092-uftc8inx 6551 14 % % NN cord-010092-uftc8inx 6551 15 . . . cord-010092-uftc8inx 6552 1 The the DT cord-010092-uftc8inx 6552 2 amount amount NN cord-010092-uftc8inx 6552 3 of of IN cord-010092-uftc8inx 6552 4 platelets platelet NNS cord-010092-uftc8inx 6552 5 and and CC cord-010092-uftc8inx 6552 6 platelet platelet NN cord-010092-uftc8inx 6552 7 concentration concentration NN cord-010092-uftc8inx 6552 8 in in IN cord-010092-uftc8inx 6552 9 unit unit NN cord-010092-uftc8inx 6552 10 was be VBD cord-010092-uftc8inx 6552 11 lower low JJR cord-010092-uftc8inx 6552 12 in in IN cord-010092-uftc8inx 6552 13 CPP CPP NNP cord-010092-uftc8inx 6552 14 compared compare VBN cord-010092-uftc8inx 6552 15 to to IN cord-010092-uftc8inx 6552 16 FP FP NNP cord-010092-uftc8inx 6552 17 , , , cord-010092-uftc8inx 6552 18 but but CC cord-010092-uftc8inx 6552 19 high high JJ cord-010092-uftc8inx 6552 20 enough enough RB cord-010092-uftc8inx 6552 21 ( ( -LRB- cord-010092-uftc8inx 6552 22 amount amount NN cord-010092-uftc8inx 6552 23 194 194 CD cord-010092-uftc8inx 6552 24 9 9 CD cord-010092-uftc8inx 6552 25 10 10 CD cord-010092-uftc8inx 6552 26 9 9 CD cord-010092-uftc8inx 6552 27 /unit /unit , cord-010092-uftc8inx 6552 28 , , , cord-010092-uftc8inx 6552 29 concentration concentration NN cord-010092-uftc8inx 6552 30 0.73 0.73 CD cord-010092-uftc8inx 6552 31 9 9 CD cord-010092-uftc8inx 6552 32 10 10 CD cord-010092-uftc8inx 6552 33 9 9 CD cord-010092-uftc8inx 6552 34 /unit /unit . cord-010092-uftc8inx 6552 35 ) ) -RRB- cord-010092-uftc8inx 6552 36 . . . cord-010092-uftc8inx 6553 1 Both both DT cord-010092-uftc8inx 6553 2 types type NNS cord-010092-uftc8inx 6553 3 of of IN cord-010092-uftc8inx 6553 4 PLTs plt NNS cord-010092-uftc8inx 6553 5 ( ( -LRB- cord-010092-uftc8inx 6553 6 either either CC cord-010092-uftc8inx 6553 7 PCC PCC NNP cord-010092-uftc8inx 6553 8 or or CC cord-010092-uftc8inx 6553 9 FP FP NNP cord-010092-uftc8inx 6553 10 ) ) -RRB- cord-010092-uftc8inx 6553 11 maintained maintain VBD cord-010092-uftc8inx 6553 12 an an DT cord-010092-uftc8inx 6553 13 acceptable acceptable JJ cord-010092-uftc8inx 6553 14 pH ph NN cord-010092-uftc8inx 6553 15 during during IN cord-010092-uftc8inx 6553 16 storage storage NN cord-010092-uftc8inx 6553 17 . . . cord-010092-uftc8inx 6554 1 Swirl swirl NN cord-010092-uftc8inx 6554 2 was be VBD cord-010092-uftc8inx 6554 3 on on IN cord-010092-uftc8inx 6554 4 value value NN cord-010092-uftc8inx 6554 5 3 3 CD cord-010092-uftc8inx 6554 6 in in IN cord-010092-uftc8inx 6554 7 FP FP NNP cord-010092-uftc8inx 6554 8 and and CC cord-010092-uftc8inx 6554 9 on on IN cord-010092-uftc8inx 6554 10 value value NN cord-010092-uftc8inx 6554 11 1 1 CD cord-010092-uftc8inx 6554 12 in in IN cord-010092-uftc8inx 6554 13 CPP CPP NNP cord-010092-uftc8inx 6554 14 . . . cord-010092-uftc8inx 6555 1 The the DT cord-010092-uftc8inx 6555 2 average average JJ cord-010092-uftc8inx 6555 3 plasma plasma NN cord-010092-uftc8inx 6555 4 content content NN cord-010092-uftc8inx 6555 5 in in IN cord-010092-uftc8inx 6555 6 FP FP NNP cord-010092-uftc8inx 6555 7 was be VBD cord-010092-uftc8inx 6555 8 31 31 CD cord-010092-uftc8inx 6555 9 % % NN cord-010092-uftc8inx 6555 10 compare compare VBP cord-010092-uftc8inx 6555 11 to to IN cord-010092-uftc8inx 6555 12 3.22 3.22 CD cord-010092-uftc8inx 6555 13 % % NN cord-010092-uftc8inx 6555 14 in in IN cord-010092-uftc8inx 6555 15 CPP CPP NNP cord-010092-uftc8inx 6555 16 after after IN cord-010092-uftc8inx 6555 17 reconstitution reconstitution NN cord-010092-uftc8inx 6555 18 . . . cord-010092-uftc8inx 6556 1 Measured measured JJ cord-010092-uftc8inx 6556 2 titres titre NNS cord-010092-uftc8inx 6556 3 of of IN cord-010092-uftc8inx 6556 4 IgM IgM NNP cord-010092-uftc8inx 6556 5 anti anti NNP cord-010092-uftc8inx 6556 6 - - NNP cord-010092-uftc8inx 6556 7 A A NNP cord-010092-uftc8inx 6556 8 and and CC cord-010092-uftc8inx 6556 9 anti anti JJ cord-010092-uftc8inx 6556 10 - - JJ cord-010092-uftc8inx 6556 11 B b JJ cord-010092-uftc8inx 6556 12 antibodies antibody NNS cord-010092-uftc8inx 6556 13 were be VBD cord-010092-uftc8inx 6556 14 very very RB cord-010092-uftc8inx 6556 15 low low JJ cord-010092-uftc8inx 6556 16 ( ( -LRB- cord-010092-uftc8inx 6556 17 0 0 CD cord-010092-uftc8inx 6556 18 - - HYPH cord-010092-uftc8inx 6556 19 1:2 1:2 CD cord-010092-uftc8inx 6556 20 ) ) -RRB- cord-010092-uftc8inx 6556 21 . . . cord-010092-uftc8inx 6557 1 CPP CPP NNP cord-010092-uftc8inx 6557 2 had have VBD cord-010092-uftc8inx 6557 3 faster fast JJR cord-010092-uftc8inx 6557 4 clot clot NN cord-010092-uftc8inx 6557 5 initiation initiation NN cord-010092-uftc8inx 6557 6 ( ( -LRB- cord-010092-uftc8inx 6557 7 ROTEM ROTEM NNP cord-010092-uftc8inx 6557 8 clotting clotting NN cord-010092-uftc8inx 6557 9 time time NN cord-010092-uftc8inx 6557 10 ( ( -LRB- cord-010092-uftc8inx 6557 11 CT CT NNP cord-010092-uftc8inx 6557 12 ) ) -RRB- cord-010092-uftc8inx 6557 13 in in IN cord-010092-uftc8inx 6557 14 CPP CPP NNP cord-010092-uftc8inx 6557 15 69.2 69.2 CD cord-010092-uftc8inx 6557 16 s s NNP cord-010092-uftc8inx 6557 17 , , , cord-010092-uftc8inx 6557 18 FP FP NNP cord-010092-uftc8inx 6557 19 81.8 81.8 NNP cord-010092-uftc8inx 6557 20 s s NNPS cord-010092-uftc8inx 6557 21 ) ) -RRB- cord-010092-uftc8inx 6557 22 . . . cord-010092-uftc8inx 6558 1 CPP CPP NNP cord-010092-uftc8inx 6558 2 contributes contribute VBZ cord-010092-uftc8inx 6558 3 to to IN cord-010092-uftc8inx 6558 4 a a DT cord-010092-uftc8inx 6558 5 sufficient sufficient JJ cord-010092-uftc8inx 6558 6 clot clot NN cord-010092-uftc8inx 6558 7 ( ( -LRB- cord-010092-uftc8inx 6558 8 ROTEM ROTEM NNP cord-010092-uftc8inx 6558 9 maximum maximum JJ cord-010092-uftc8inx 6558 10 clot clot NN cord-010092-uftc8inx 6558 11 firmness firmness NN cord-010092-uftc8inx 6558 12 ( ( -LRB- cord-010092-uftc8inx 6558 13 MCF MCF NNP cord-010092-uftc8inx 6558 14 ) ) -RRB- cord-010092-uftc8inx 6558 15 in in IN cord-010092-uftc8inx 6558 16 CPP CPP NNP cord-010092-uftc8inx 6558 17 39.8 39.8 CD cord-010092-uftc8inx 6558 18 mm mm NNP cord-010092-uftc8inx 6558 19 , , , cord-010092-uftc8inx 6558 20 FP FP NNP cord-010092-uftc8inx 6558 21 53.2 53.2 CD cord-010092-uftc8inx 6558 22 mm mm NNP cord-010092-uftc8inx 6558 23 ) ) -RRB- cord-010092-uftc8inx 6558 24 . . . cord-010092-uftc8inx 6559 1 Summary Summary NNP cord-010092-uftc8inx 6559 2 / / SYM cord-010092-uftc8inx 6559 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 6559 4 : : : cord-010092-uftc8inx 6560 1 Our -PRON- PRP$ cord-010092-uftc8inx 6560 2 results result NNS cord-010092-uftc8inx 6560 3 shows show VBZ cord-010092-uftc8inx 6560 4 , , , cord-010092-uftc8inx 6560 5 that that IN cord-010092-uftc8inx 6560 6 CPP CPP NNP cord-010092-uftc8inx 6560 7 have have VBP cord-010092-uftc8inx 6560 8 higher high JJR cord-010092-uftc8inx 6560 9 procoagulation procoagulation NN cord-010092-uftc8inx 6560 10 activity activity NN cord-010092-uftc8inx 6560 11 and and CC cord-010092-uftc8inx 6560 12 simultaneously simultaneously RB cord-010092-uftc8inx 6560 13 lower low JJR cord-010092-uftc8inx 6560 14 clot clot NN cord-010092-uftc8inx 6560 15 firmness firmness NN cord-010092-uftc8inx 6560 16 . . . cord-010092-uftc8inx 6561 1 Thawing thawing NN cord-010092-uftc8inx 6561 2 and and CC cord-010092-uftc8inx 6561 3 reconstitution reconstitution NN cord-010092-uftc8inx 6561 4 of of IN cord-010092-uftc8inx 6561 5 platelets platelet NNS cord-010092-uftc8inx 6561 6 are be VBP cord-010092-uftc8inx 6561 7 easy easy JJ cord-010092-uftc8inx 6561 8 and and CC cord-010092-uftc8inx 6561 9 fast fast JJ cord-010092-uftc8inx 6561 10 processes process NNS cord-010092-uftc8inx 6561 11 if if IN cord-010092-uftc8inx 6561 12 platelet platelet NN cord-010092-uftc8inx 6561 13 additive additive NN cord-010092-uftc8inx 6561 14 solution solution NN cord-010092-uftc8inx 6561 15 is be VBZ cord-010092-uftc8inx 6561 16 used use VBN cord-010092-uftc8inx 6561 17 . . . cord-010092-uftc8inx 6562 1 This this DT cord-010092-uftc8inx 6562 2 method method NN cord-010092-uftc8inx 6562 3 helps help VBZ cord-010092-uftc8inx 6562 4 to to TO cord-010092-uftc8inx 6562 5 increase increase VB cord-010092-uftc8inx 6562 6 the the DT cord-010092-uftc8inx 6562 7 availability availability NN cord-010092-uftc8inx 6562 8 of of IN cord-010092-uftc8inx 6562 9 platelets platelet NNS cord-010092-uftc8inx 6562 10 in in IN cord-010092-uftc8inx 6562 11 emergency emergency NN cord-010092-uftc8inx 6562 12 medicine medicine NN cord-010092-uftc8inx 6562 13 . . . cord-010092-uftc8inx 6563 1 Low low JJ cord-010092-uftc8inx 6563 2 plasma plasma NN cord-010092-uftc8inx 6563 3 content content NN cord-010092-uftc8inx 6563 4 in in IN cord-010092-uftc8inx 6563 5 CPP CPP NNP cord-010092-uftc8inx 6563 6 enables enable VBZ cord-010092-uftc8inx 6563 7 their -PRON- PRP$ cord-010092-uftc8inx 6563 8 use use NN cord-010092-uftc8inx 6563 9 as as IN cord-010092-uftc8inx 6563 10 washed wash VBN cord-010092-uftc8inx 6563 11 platelet platelet NN cord-010092-uftc8inx 6563 12 product product NN cord-010092-uftc8inx 6563 13 in in IN cord-010092-uftc8inx 6563 14 specific specific JJ cord-010092-uftc8inx 6563 15 groups group NNS cord-010092-uftc8inx 6563 16 of of IN cord-010092-uftc8inx 6563 17 patients patient NNS cord-010092-uftc8inx 6563 18 . . . cord-010092-uftc8inx 6564 1 Methods method NNS cord-010092-uftc8inx 6564 2 : : : cord-010092-uftc8inx 6564 3 After after IN cord-010092-uftc8inx 6564 4 donation donation NN cord-010092-uftc8inx 6564 5 , , , cord-010092-uftc8inx 6564 6 the the DT cord-010092-uftc8inx 6564 7 whole whole JJ cord-010092-uftc8inx 6564 8 blood blood NN cord-010092-uftc8inx 6564 9 was be VBD cord-010092-uftc8inx 6564 10 stored store VBN cord-010092-uftc8inx 6564 11 in in IN cord-010092-uftc8inx 6564 12 room room NN cord-010092-uftc8inx 6564 13 temperature temperature NN cord-010092-uftc8inx 6564 14 overnight overnight RB cord-010092-uftc8inx 6564 15 before before IN cord-010092-uftc8inx 6564 16 separating separate VBG cord-010092-uftc8inx 6564 17 next next JJ cord-010092-uftc8inx 6564 18 morning morning NN cord-010092-uftc8inx 6564 19 by by IN cord-010092-uftc8inx 6564 20 Reveos Reveos NNP cord-010092-uftc8inx 6564 21 â â CD cord-010092-uftc8inx 6564 22 system system NN cord-010092-uftc8inx 6564 23 . . . cord-010092-uftc8inx 6565 1 Seven seven CD cord-010092-uftc8inx 6565 2 ABO ABO NNP cord-010092-uftc8inx 6565 3 compatible compatible JJ cord-010092-uftc8inx 6565 4 IPUs ipu NNS cord-010092-uftc8inx 6565 5 , , , cord-010092-uftc8inx 6565 6 each each DT cord-010092-uftc8inx 6565 7 with with IN cord-010092-uftc8inx 6565 8 a a DT cord-010092-uftc8inx 6565 9 target target NN cord-010092-uftc8inx 6565 10 volume volume NN cord-010092-uftc8inx 6565 11 of of IN cord-010092-uftc8inx 6565 12 24 24 CD cord-010092-uftc8inx 6565 13 mL ml NN cord-010092-uftc8inx 6565 14 , , , cord-010092-uftc8inx 6565 15 were be VBD cord-010092-uftc8inx 6565 16 selected select VBN cord-010092-uftc8inx 6565 17 and and CC cord-010092-uftc8inx 6565 18 then then RB cord-010092-uftc8inx 6565 19 they -PRON- PRP cord-010092-uftc8inx 6565 20 were be VBD cord-010092-uftc8inx 6565 21 connected connect VBN cord-010092-uftc8inx 6565 22 to to IN cord-010092-uftc8inx 6565 23 the the DT cord-010092-uftc8inx 6565 24 pooling pooling NN cord-010092-uftc8inx 6565 25 set set NN cord-010092-uftc8inx 6565 26 provided provide VBN cord-010092-uftc8inx 6565 27 by by IN cord-010092-uftc8inx 6565 28 Terumo Terumo NNP cord-010092-uftc8inx 6565 29 BCT BCT NNP cord-010092-uftc8inx 6565 30 . . . cord-010092-uftc8inx 6566 1 Prior prior RB cord-010092-uftc8inx 6566 2 to to IN cord-010092-uftc8inx 6566 3 the the DT cord-010092-uftc8inx 6566 4 pooling pooling NN cord-010092-uftc8inx 6566 5 of of IN cord-010092-uftc8inx 6566 6 IPUs ipu NNS cord-010092-uftc8inx 6566 7 , , , cord-010092-uftc8inx 6566 8 250 250 CD cord-010092-uftc8inx 6566 9 mL mL NNS cord-010092-uftc8inx 6566 10 of of IN cord-010092-uftc8inx 6566 11 additive additive NN cord-010092-uftc8inx 6566 12 solution solution NN cord-010092-uftc8inx 6566 13 ( ( -LRB- cord-010092-uftc8inx 6566 14 T T NNP cord-010092-uftc8inx 6566 15 - - HYPH cord-010092-uftc8inx 6566 16 PAS+ PAS+ NNP cord-010092-uftc8inx 6566 17 provided provide VBN cord-010092-uftc8inx 6566 18 by by IN cord-010092-uftc8inx 6566 19 Terumo Terumo NNP cord-010092-uftc8inx 6566 20 BCT BCT NNP cord-010092-uftc8inx 6566 21 ) ) -RRB- cord-010092-uftc8inx 6566 22 was be VBD cord-010092-uftc8inx 6566 23 added add VBN cord-010092-uftc8inx 6566 24 and and CC cord-010092-uftc8inx 6566 25 distributed distribute VBN cord-010092-uftc8inx 6566 26 evenly evenly RB cord-010092-uftc8inx 6566 27 between between IN cord-010092-uftc8inx 6566 28 the the DT cord-010092-uftc8inx 6566 29 IPU IPU NNP cord-010092-uftc8inx 6566 30 bags bag NNS cord-010092-uftc8inx 6566 31 . . . cord-010092-uftc8inx 6567 1 The the DT cord-010092-uftc8inx 6567 2 pooling pooling NN cord-010092-uftc8inx 6567 3 set set NN cord-010092-uftc8inx 6567 4 was be VBD cord-010092-uftc8inx 6567 5 then then RB cord-010092-uftc8inx 6567 6 kept keep VBN cord-010092-uftc8inx 6567 7 1 1 CD cord-010092-uftc8inx 6567 8 h h NN cord-010092-uftc8inx 6567 9 on on IN cord-010092-uftc8inx 6567 10 bench bench NN cord-010092-uftc8inx 6567 11 in in IN cord-010092-uftc8inx 6567 12 room room NN cord-010092-uftc8inx 6567 13 temperature temperature NN cord-010092-uftc8inx 6567 14 followed follow VBN cord-010092-uftc8inx 6567 15 by by IN cord-010092-uftc8inx 6567 16 1 1 CD cord-010092-uftc8inx 6567 17 h h NN cord-010092-uftc8inx 6567 18 on on IN cord-010092-uftc8inx 6567 19 agitator agitator NN cord-010092-uftc8inx 6567 20 at at IN cord-010092-uftc8inx 6567 21 22 22 CD cord-010092-uftc8inx 6567 22 AE AE NNP cord-010092-uftc8inx 6567 23 2 2 CD cord-010092-uftc8inx 6567 24 ° ° NN cord-010092-uftc8inx 6567 25 C c NN cord-010092-uftc8inx 6567 26 . . . cord-010092-uftc8inx 6568 1 After after IN cord-010092-uftc8inx 6568 2 filtration filtration NN cord-010092-uftc8inx 6568 3 , , , cord-010092-uftc8inx 6568 4 the the DT cord-010092-uftc8inx 6568 5 pool pool NN cord-010092-uftc8inx 6568 6 might may MD cord-010092-uftc8inx 6568 7 be be VB cord-010092-uftc8inx 6568 8 manually manually RB cord-010092-uftc8inx 6568 9 adjusted adjust VBN cord-010092-uftc8inx 6568 10 if if IN cord-010092-uftc8inx 6568 11 its -PRON- PRP$ cord-010092-uftc8inx 6568 12 volume volume NN cord-010092-uftc8inx 6568 13 exceeded exceed VBD cord-010092-uftc8inx 6568 14 the the DT cord-010092-uftc8inx 6568 15 maximum maximum NN cord-010092-uftc8inx 6568 16 of of IN cord-010092-uftc8inx 6568 17 420 420 CD cord-010092-uftc8inx 6568 18 mL ml NN cord-010092-uftc8inx 6568 19 to to TO cord-010092-uftc8inx 6568 20 meet meet VB cord-010092-uftc8inx 6568 21 the the DT cord-010092-uftc8inx 6568 22 requirements requirement NNS cord-010092-uftc8inx 6568 23 by by IN cord-010092-uftc8inx 6568 24 the the DT cord-010092-uftc8inx 6568 25 INTERCEPT INTERCEPT NNP cord-010092-uftc8inx 6568 26 TM TM NNP cord-010092-uftc8inx 6568 27 Blood Blood NNP cord-010092-uftc8inx 6568 28 System System NNP cord-010092-uftc8inx 6568 29 . . . cord-010092-uftc8inx 6569 1 The the DT cord-010092-uftc8inx 6569 2 final final JJ cord-010092-uftc8inx 6569 3 products product NNS cord-010092-uftc8inx 6569 4 were be VBD cord-010092-uftc8inx 6569 5 two two CD cord-010092-uftc8inx 6569 6 pathogen pathogen NN cord-010092-uftc8inx 6569 7 - - HYPH cord-010092-uftc8inx 6569 8 reduced reduce VBN cord-010092-uftc8inx 6569 9 platelet platelet NN cord-010092-uftc8inx 6569 10 units unit NNS cord-010092-uftc8inx 6569 11 with with IN cord-010092-uftc8inx 6569 12 a a DT cord-010092-uftc8inx 6569 13 shelf shelf NN cord-010092-uftc8inx 6569 14 life life NN cord-010092-uftc8inx 6569 15 of of IN cord-010092-uftc8inx 6569 16 7 7 CD cord-010092-uftc8inx 6569 17 days day NNS cord-010092-uftc8inx 6569 18 . . . cord-010092-uftc8inx 6570 1 Results result NNS cord-010092-uftc8inx 6570 2 : : : cord-010092-uftc8inx 6571 1 During during IN cord-010092-uftc8inx 6571 2 validation validation NN cord-010092-uftc8inx 6571 3 of of IN cord-010092-uftc8inx 6571 4 the the DT cord-010092-uftc8inx 6571 5 method method NN cord-010092-uftc8inx 6571 6 , , , cord-010092-uftc8inx 6571 7 12 12 CD cord-010092-uftc8inx 6571 8 pathogen pathogen NN cord-010092-uftc8inx 6571 9 - - HYPH cord-010092-uftc8inx 6571 10 reduced reduce VBN cord-010092-uftc8inx 6571 11 platelet platelet NN cord-010092-uftc8inx 6571 12 units unit NNS cord-010092-uftc8inx 6571 13 were be VBD cord-010092-uftc8inx 6571 14 controlled control VBN cord-010092-uftc8inx 6571 15 , , , cord-010092-uftc8inx 6571 16 in in IN cord-010092-uftc8inx 6571 17 addition addition NN cord-010092-uftc8inx 6571 18 to to IN cord-010092-uftc8inx 6571 19 the the DT cord-010092-uftc8inx 6571 20 platelet platelet NN cord-010092-uftc8inx 6571 21 count count NN cord-010092-uftc8inx 6571 22 , , , cord-010092-uftc8inx 6571 23 for for IN cord-010092-uftc8inx 6571 24 pH pH NNP cord-010092-uftc8inx 6571 25 , , , cord-010092-uftc8inx 6571 26 glucose glucose NN cord-010092-uftc8inx 6571 27 , , , cord-010092-uftc8inx 6571 28 pO2 pO2 NNP cord-010092-uftc8inx 6571 29 , , , cord-010092-uftc8inx 6571 30 pCO2 pCO2 NNP cord-010092-uftc8inx 6571 31 and and CC cord-010092-uftc8inx 6571 32 lactate lactate NN cord-010092-uftc8inx 6571 33 on on IN cord-010092-uftc8inx 6571 34 day day NN cord-010092-uftc8inx 6571 35 2 2 CD cord-010092-uftc8inx 6571 36 , , , cord-010092-uftc8inx 6571 37 5 5 CD cord-010092-uftc8inx 6571 38 and and CC cord-010092-uftc8inx 6571 39 7 7 CD cord-010092-uftc8inx 6571 40 of of IN cord-010092-uftc8inx 6571 41 storage storage NN cord-010092-uftc8inx 6571 42 . . . cord-010092-uftc8inx 6572 1 The the DT cord-010092-uftc8inx 6572 2 platelet platelet NN cord-010092-uftc8inx 6572 3 count count NN cord-010092-uftc8inx 6572 4 was be VBD cord-010092-uftc8inx 6572 5 2.27 2.27 CD cord-010092-uftc8inx 6572 6 AE AE NNP cord-010092-uftc8inx 6572 7 15 15 CD cord-010092-uftc8inx 6572 8 9 9 CD cord-010092-uftc8inx 6572 9 10 10 CD cord-010092-uftc8inx 6572 10 11 11 CD cord-010092-uftc8inx 6572 11 per per IN cord-010092-uftc8inx 6572 12 unit unit NN cord-010092-uftc8inx 6572 13 on on IN cord-010092-uftc8inx 6572 14 day day NN cord-010092-uftc8inx 6572 15 2 2 CD cord-010092-uftc8inx 6572 16 . . . cord-010092-uftc8inx 6573 1 The the DT cord-010092-uftc8inx 6573 2 pH pH NNP cord-010092-uftc8inx 6573 3 value value NN cord-010092-uftc8inx 6573 4 was be VBD cord-010092-uftc8inx 6573 5 6.9 6.9 CD cord-010092-uftc8inx 6573 6 on on IN cord-010092-uftc8inx 6573 7 day day NN cord-010092-uftc8inx 6573 8 2 2 CD cord-010092-uftc8inx 6573 9 , , , cord-010092-uftc8inx 6573 10 7.1 7.1 CD cord-010092-uftc8inx 6573 11 on on IN cord-010092-uftc8inx 6573 12 day day NN cord-010092-uftc8inx 6573 13 5 5 CD cord-010092-uftc8inx 6573 14 , , , cord-010092-uftc8inx 6573 15 and and CC cord-010092-uftc8inx 6573 16 6.9 6.9 CD cord-010092-uftc8inx 6573 17 on on IN cord-010092-uftc8inx 6573 18 day day NN cord-010092-uftc8inx 6573 19 7 7 CD cord-010092-uftc8inx 6573 20 . . . cord-010092-uftc8inx 6574 1 The the DT cord-010092-uftc8inx 6574 2 glucose glucose NN cord-010092-uftc8inx 6574 3 concentration concentration NN cord-010092-uftc8inx 6574 4 decreased decrease VBD cord-010092-uftc8inx 6574 5 from from IN cord-010092-uftc8inx 6574 6 5.8 5.8 CD cord-010092-uftc8inx 6574 7 to to IN cord-010092-uftc8inx 6574 8 3.5 3.5 CD cord-010092-uftc8inx 6574 9 and and CC cord-010092-uftc8inx 6574 10 1.6 1.6 CD cord-010092-uftc8inx 6574 11 mmol mmol JJ cord-010092-uftc8inx 6574 12 / / SYM cord-010092-uftc8inx 6574 13 L l NN cord-010092-uftc8inx 6574 14 on on IN cord-010092-uftc8inx 6574 15 day day NN cord-010092-uftc8inx 6574 16 2 2 CD cord-010092-uftc8inx 6574 17 , , , cord-010092-uftc8inx 6574 18 5 5 CD cord-010092-uftc8inx 6574 19 and and CC cord-010092-uftc8inx 6574 20 7 7 CD cord-010092-uftc8inx 6574 21 , , , cord-010092-uftc8inx 6574 22 respectively respectively RB cord-010092-uftc8inx 6574 23 . . . cord-010092-uftc8inx 6575 1 The the DT cord-010092-uftc8inx 6575 2 mean mean JJ cord-010092-uftc8inx 6575 3 pO2 pO2 NNP cord-010092-uftc8inx 6575 4 level level NN cord-010092-uftc8inx 6575 5 was be VBD cord-010092-uftc8inx 6575 6 25.3 25.3 CD cord-010092-uftc8inx 6575 7 , , , cord-010092-uftc8inx 6575 8 25.0 25.0 CD cord-010092-uftc8inx 6575 9 and and CC cord-010092-uftc8inx 6575 10 28.7 28.7 CD cord-010092-uftc8inx 6575 11 kPa kPa NNS cord-010092-uftc8inx 6575 12 while while IN cord-010092-uftc8inx 6575 13 the the DT cord-010092-uftc8inx 6575 14 mean mean NN cord-010092-uftc8inx 6575 15 pCO2 pCO2 NNP cord-010092-uftc8inx 6575 16 was be VBD cord-010092-uftc8inx 6575 17 3.8 3.8 CD cord-010092-uftc8inx 6575 18 , , , cord-010092-uftc8inx 6575 19 1.7 1.7 CD cord-010092-uftc8inx 6575 20 and and CC cord-010092-uftc8inx 6575 21 1.8 1.8 CD cord-010092-uftc8inx 6575 22 kPa kPa NNS cord-010092-uftc8inx 6575 23 and and CC cord-010092-uftc8inx 6575 24 the the DT cord-010092-uftc8inx 6575 25 lactate lactate NN cord-010092-uftc8inx 6575 26 concentration concentration NN cord-010092-uftc8inx 6575 27 was be VBD cord-010092-uftc8inx 6575 28 5.9 5.9 CD cord-010092-uftc8inx 6575 29 , , , cord-010092-uftc8inx 6575 30 9.6 9.6 CD cord-010092-uftc8inx 6575 31 and and CC cord-010092-uftc8inx 6575 32 12.9 12.9 CD cord-010092-uftc8inx 6575 33 mmol mmol JJ cord-010092-uftc8inx 6575 34 / / SYM cord-010092-uftc8inx 6575 35 L L NNP cord-010092-uftc8inx 6575 36 on on IN cord-010092-uftc8inx 6575 37 day day NN cord-010092-uftc8inx 6575 38 2 2 CD cord-010092-uftc8inx 6575 39 , , , cord-010092-uftc8inx 6575 40 5 5 CD cord-010092-uftc8inx 6575 41 and and CC cord-010092-uftc8inx 6575 42 7 7 CD cord-010092-uftc8inx 6575 43 , , , cord-010092-uftc8inx 6575 44 respectively respectively RB cord-010092-uftc8inx 6575 45 . . . cord-010092-uftc8inx 6576 1 Since since IN cord-010092-uftc8inx 6576 2 routine routine JJ cord-010092-uftc8inx 6576 3 implementation implementation NN cord-010092-uftc8inx 6576 4 of of IN cord-010092-uftc8inx 6576 5 the the DT cord-010092-uftc8inx 6576 6 method method NN cord-010092-uftc8inx 6576 7 in in IN cord-010092-uftc8inx 6576 8 April April NNP cord-010092-uftc8inx 6576 9 2017 2017 CD cord-010092-uftc8inx 6576 10 , , , cord-010092-uftc8inx 6576 11 regular regular JJ cord-010092-uftc8inx 6576 12 quality quality NN cord-010092-uftc8inx 6576 13 controls control NNS cord-010092-uftc8inx 6576 14 showed show VBD cord-010092-uftc8inx 6576 15 an an DT cord-010092-uftc8inx 6576 16 average average NN cord-010092-uftc8inx 6576 17 of of IN cord-010092-uftc8inx 6576 18 platelet platelet NN cord-010092-uftc8inx 6576 19 count count NN cord-010092-uftc8inx 6576 20 of of IN cord-010092-uftc8inx 6576 21 2.63 2.63 CD cord-010092-uftc8inx 6576 22 AE AE NNP cord-010092-uftc8inx 6576 23 34 34 CD cord-010092-uftc8inx 6576 24 9 9 CD cord-010092-uftc8inx 6576 25 10 10 CD cord-010092-uftc8inx 6576 26 11 11 CD cord-010092-uftc8inx 6576 27 ( ( -LRB- cord-010092-uftc8inx 6576 28 n n NN cord-010092-uftc8inx 6576 29 = = SYM cord-010092-uftc8inx 6576 30 161 161 CD cord-010092-uftc8inx 6576 31 ) ) -RRB- cord-010092-uftc8inx 6576 32 with with IN cord-010092-uftc8inx 6576 33 a a DT cord-010092-uftc8inx 6576 34 volume volume NN cord-010092-uftc8inx 6576 35 of of IN cord-010092-uftc8inx 6576 36 204 204 CD cord-010092-uftc8inx 6576 37 AE AE NNP cord-010092-uftc8inx 6576 38 7 7 CD cord-010092-uftc8inx 6576 39 mL ml NN cord-010092-uftc8inx 6576 40 per per IN cord-010092-uftc8inx 6576 41 unit unit NN cord-010092-uftc8inx 6576 42 . . . cord-010092-uftc8inx 6577 1 Summary Summary NNP cord-010092-uftc8inx 6577 2 / / SYM cord-010092-uftc8inx 6577 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 6577 4 : : : cord-010092-uftc8inx 6578 1 The the DT cord-010092-uftc8inx 6578 2 validation validation NN cord-010092-uftc8inx 6578 3 of of IN cord-010092-uftc8inx 6578 4 the the DT cord-010092-uftc8inx 6578 5 method method NN cord-010092-uftc8inx 6578 6 and and CC cord-010092-uftc8inx 6578 7 the the DT cord-010092-uftc8inx 6578 8 following follow VBG cord-010092-uftc8inx 6578 9 two two CD cord-010092-uftc8inx 6578 10 years year NNS cord-010092-uftc8inx 6578 11 of of IN cord-010092-uftc8inx 6578 12 experience experience NN cord-010092-uftc8inx 6578 13 in in IN cord-010092-uftc8inx 6578 14 routine routine JJ cord-010092-uftc8inx 6578 15 shows show NNS cord-010092-uftc8inx 6578 16 that that IN cord-010092-uftc8inx 6578 17 the the DT cord-010092-uftc8inx 6578 18 pooling pooling NN cord-010092-uftc8inx 6578 19 of of IN cord-010092-uftc8inx 6578 20 7 7 CD cord-010092-uftc8inx 6578 21 IPUs ipu NNS cord-010092-uftc8inx 6578 22 processed process VBN cord-010092-uftc8inx 6578 23 in in IN cord-010092-uftc8inx 6578 24 Reveos Reveos NNP cord-010092-uftc8inx 6578 25 â â , cord-010092-uftc8inx 6578 26 system system NN cord-010092-uftc8inx 6578 27 meet meet VBP cord-010092-uftc8inx 6578 28 the the DT cord-010092-uftc8inx 6578 29 requirements requirement NNS cord-010092-uftc8inx 6578 30 needed need VBN cord-010092-uftc8inx 6578 31 for for IN cord-010092-uftc8inx 6578 32 INTERCEPT INTERCEPT NNP cord-010092-uftc8inx 6578 33 TM TM NNP cord-010092-uftc8inx 6578 34 DS DS NNP cord-010092-uftc8inx 6578 35 processing processing NN cord-010092-uftc8inx 6578 36 set set VBN cord-010092-uftc8inx 6578 37 for for IN cord-010092-uftc8inx 6578 38 pathogen pathogen NN cord-010092-uftc8inx 6578 39 reduction reduction NN cord-010092-uftc8inx 6578 40 of of IN cord-010092-uftc8inx 6578 41 platelets platelet NNS cord-010092-uftc8inx 6578 42 . . . cord-010092-uftc8inx 6579 1 The the DT cord-010092-uftc8inx 6579 2 results result NNS cord-010092-uftc8inx 6579 3 from from IN cord-010092-uftc8inx 6579 4 the the DT cord-010092-uftc8inx 6579 5 quality quality NN cord-010092-uftc8inx 6579 6 controls control NNS cord-010092-uftc8inx 6579 7 of of IN cord-010092-uftc8inx 6579 8 the the DT cord-010092-uftc8inx 6579 9 final final JJ cord-010092-uftc8inx 6579 10 platelet platelet NN cord-010092-uftc8inx 6579 11 units unit NNS cord-010092-uftc8inx 6579 12 were be VBD cord-010092-uftc8inx 6579 13 in in IN cord-010092-uftc8inx 6579 14 accordance accordance NN cord-010092-uftc8inx 6579 15 with with IN cord-010092-uftc8inx 6579 16 the the DT cord-010092-uftc8inx 6579 17 local local JJ cord-010092-uftc8inx 6579 18 and and CC cord-010092-uftc8inx 6579 19 EU EU NNP cord-010092-uftc8inx 6579 20 guidelines guideline NNS cord-010092-uftc8inx 6579 21 . . . cord-010092-uftc8inx 6580 1 Methods method NNS cord-010092-uftc8inx 6580 2 : : : cord-010092-uftc8inx 6581 1 Data datum NNS cord-010092-uftc8inx 6581 2 was be VBD cord-010092-uftc8inx 6581 3 analyzed analyze VBN cord-010092-uftc8inx 6581 4 from from IN cord-010092-uftc8inx 6581 5 11 11 CD cord-010092-uftc8inx 6581 6 published publish VBN cord-010092-uftc8inx 6581 7 and and CC cord-010092-uftc8inx 6581 8 unpublished unpublished JJ cord-010092-uftc8inx 6581 9 clinical clinical JJ cord-010092-uftc8inx 6581 10 studies study NNS cord-010092-uftc8inx 6581 11 that that WDT cord-010092-uftc8inx 6581 12 performed perform VBD cord-010092-uftc8inx 6581 13 both both CC cord-010092-uftc8inx 6581 14 primary primary JJ cord-010092-uftc8inx 6581 15 and and CC cord-010092-uftc8inx 6581 16 secondary secondary JJ cord-010092-uftc8inx 6581 17 testing testing NN cord-010092-uftc8inx 6581 18 of of IN cord-010092-uftc8inx 6581 19 platelets platelet NNS cord-010092-uftc8inx 6581 20 using use VBG cord-010092-uftc8inx 6581 21 the the DT cord-010092-uftc8inx 6581 22 BTA BTA NNP cord-010092-uftc8inx 6581 23 System System NNP cord-010092-uftc8inx 6581 24 . . . cord-010092-uftc8inx 6582 1 The the DT cord-010092-uftc8inx 6582 2 studies study NNS cord-010092-uftc8inx 6582 3 included include VBD cord-010092-uftc8inx 6582 4 apheresis apheresis NN cord-010092-uftc8inx 6582 5 and and CC cord-010092-uftc8inx 6582 6 whole whole JJ cord-010092-uftc8inx 6582 7 blood blood NN cord-010092-uftc8inx 6582 8 derived derive VBD cord-010092-uftc8inx 6582 9 buffy buffy NNP cord-010092-uftc8inx 6582 10 coat coat NNP cord-010092-uftc8inx 6582 11 platelets platelet NNS cord-010092-uftc8inx 6582 12 and and CC cord-010092-uftc8inx 6582 13 tested test VBD cord-010092-uftc8inx 6582 14 4 4 CD cord-010092-uftc8inx 6582 15 - - SYM cord-010092-uftc8inx 6582 16 10 10 CD cord-010092-uftc8inx 6582 17 mL ml NN cord-010092-uftc8inx 6582 18 sample sample NN cord-010092-uftc8inx 6582 19 volume volume NN cord-010092-uftc8inx 6582 20 per per IN cord-010092-uftc8inx 6582 21 culture culture NN cord-010092-uftc8inx 6582 22 bottle bottle NN cord-010092-uftc8inx 6582 23 . . . cord-010092-uftc8inx 6583 1 The the DT cord-010092-uftc8inx 6583 2 11 11 CD cord-010092-uftc8inx 6583 3 studies study NNS cord-010092-uftc8inx 6583 4 classified classify VBD cord-010092-uftc8inx 6583 5 results result NNS cord-010092-uftc8inx 6583 6 based base VBN cord-010092-uftc8inx 6583 7 on on IN cord-010092-uftc8inx 6583 8 AABB AABB NNP cord-010092-uftc8inx 6583 9 Bulletin Bulletin NNP cord-010092-uftc8inx 6583 10 04 04 CD cord-010092-uftc8inx 6583 11 - - HYPH cord-010092-uftc8inx 6583 12 07 07 CD cord-010092-uftc8inx 6583 13 definitions definition NNS cord-010092-uftc8inx 6583 14 with with IN cord-010092-uftc8inx 6583 15 some some DT cord-010092-uftc8inx 6583 16 modifications modification NNS cord-010092-uftc8inx 6583 17 . . . cord-010092-uftc8inx 6584 1 The the DT cord-010092-uftc8inx 6584 2 following follow VBG cord-010092-uftc8inx 6584 3 assumptions assumption NNS cord-010092-uftc8inx 6584 4 were be VBD cord-010092-uftc8inx 6584 5 made make VBN cord-010092-uftc8inx 6584 6 including include VBG cord-010092-uftc8inx 6584 7 : : : cord-010092-uftc8inx 6585 1 • • NNP cord-010092-uftc8inx 6586 1 Data datum NNS cord-010092-uftc8inx 6586 2 was be VBD cord-010092-uftc8inx 6586 3 summarized summarize VBN cord-010092-uftc8inx 6586 4 as as IN cord-010092-uftc8inx 6586 5 total total JJ cord-010092-uftc8inx 6586 6 number number NN cord-010092-uftc8inx 6586 7 of of IN cord-010092-uftc8inx 6586 8 positive positive JJ cord-010092-uftc8inx 6586 9 tests test NNS cord-010092-uftc8inx 6586 10 , , , cord-010092-uftc8inx 6586 11 observed observe VBN cord-010092-uftc8inx 6586 12 by by IN cord-010092-uftc8inx 6586 13 the the DT cord-010092-uftc8inx 6586 14 total total JJ cord-010092-uftc8inx 6586 15 number number NN cord-010092-uftc8inx 6586 16 of of IN cord-010092-uftc8inx 6586 17 tests test NNS cord-010092-uftc8inx 6586 18 performed perform VBN cord-010092-uftc8inx 6586 19 on on IN cord-010092-uftc8inx 6586 20 each each DT cord-010092-uftc8inx 6586 21 day day NN cord-010092-uftc8inx 6586 22 post post NN cord-010092-uftc8inx 6586 23 collection collection NN cord-010092-uftc8inx 6586 24 ; ; : cord-010092-uftc8inx 6586 25 • • NNP cord-010092-uftc8inx 6586 26 It -PRON- PRP cord-010092-uftc8inx 6586 27 was be VBD cord-010092-uftc8inx 6586 28 assumed assume VBN cord-010092-uftc8inx 6586 29 that that IN cord-010092-uftc8inx 6586 30 one one CD cord-010092-uftc8inx 6586 31 test test NN cord-010092-uftc8inx 6586 32 was be VBD cord-010092-uftc8inx 6586 33 performed perform VBN cord-010092-uftc8inx 6586 34 per per IN cord-010092-uftc8inx 6586 35 platelet platelet NN cord-010092-uftc8inx 6586 36 unit unit NN cord-010092-uftc8inx 6586 37 ; ; : cord-010092-uftc8inx 6586 38 • • NNP cord-010092-uftc8inx 6586 39 All all DT cord-010092-uftc8inx 6586 40 units unit NNS cord-010092-uftc8inx 6586 41 eligible eligible JJ cord-010092-uftc8inx 6586 42 for for IN cord-010092-uftc8inx 6586 43 secondary secondary JJ cord-010092-uftc8inx 6586 44 testing testing NN cord-010092-uftc8inx 6586 45 were be VBD cord-010092-uftc8inx 6586 46 negative negative JJ cord-010092-uftc8inx 6586 47 by by IN cord-010092-uftc8inx 6586 48 the the DT cord-010092-uftc8inx 6586 49 primary primary JJ cord-010092-uftc8inx 6586 50 test test NN cord-010092-uftc8inx 6587 1 The the DT cord-010092-uftc8inx 6587 2 data datum NNS cord-010092-uftc8inx 6587 3 needed need VBD cord-010092-uftc8inx 6587 4 to to TO cord-010092-uftc8inx 6587 5 demonstrate demonstrate VB cord-010092-uftc8inx 6587 6 a a DT cord-010092-uftc8inx 6587 7 benefit benefit NN cord-010092-uftc8inx 6587 8 for for IN cord-010092-uftc8inx 6587 9 the the DT cord-010092-uftc8inx 6587 10 use use NN cord-010092-uftc8inx 6587 11 of of IN cord-010092-uftc8inx 6587 12 the the DT cord-010092-uftc8inx 6587 13 BTA BTA NNP cord-010092-uftc8inx 6587 14 3D 3D NNP cord-010092-uftc8inx 6587 15 Systems Systems NNP cord-010092-uftc8inx 6587 16 for for IN cord-010092-uftc8inx 6587 17 detecting detect VBG cord-010092-uftc8inx 6587 18 contamination contamination NN cord-010092-uftc8inx 6587 19 that that WDT cord-010092-uftc8inx 6587 20 was be VBD cord-010092-uftc8inx 6587 21 not not RB cord-010092-uftc8inx 6587 22 revealed reveal VBN cord-010092-uftc8inx 6587 23 by by IN cord-010092-uftc8inx 6587 24 previous previous JJ cord-010092-uftc8inx 6587 25 bacterial bacterial JJ cord-010092-uftc8inx 6587 26 testing testing NN cord-010092-uftc8inx 6587 27 as as RB cord-010092-uftc8inx 6587 28 well well RB cord-010092-uftc8inx 6587 29 as as IN cord-010092-uftc8inx 6587 30 clinical clinical JJ cord-010092-uftc8inx 6587 31 specificity specificity NN cord-010092-uftc8inx 6587 32 . . . cord-010092-uftc8inx 6588 1 Results result NNS cord-010092-uftc8inx 6588 2 : : : cord-010092-uftc8inx 6589 1 A a DT cord-010092-uftc8inx 6589 2 total total NN cord-010092-uftc8inx 6589 3 of of IN cord-010092-uftc8inx 6589 4 217,932 217,932 CD cord-010092-uftc8inx 6589 5 platelet platelet NN cord-010092-uftc8inx 6589 6 units unit NNS cord-010092-uftc8inx 6589 7 from from IN cord-010092-uftc8inx 6589 8 the the DT cord-010092-uftc8inx 6589 9 studies study NNS cord-010092-uftc8inx 6589 10 where where WRB cord-010092-uftc8inx 6589 11 secondary secondary JJ cord-010092-uftc8inx 6589 12 testing testing NN cord-010092-uftc8inx 6589 13 of of IN cord-010092-uftc8inx 6589 14 platelets platelet NNS cord-010092-uftc8inx 6589 15 was be VBD cord-010092-uftc8inx 6589 16 performed perform VBN cord-010092-uftc8inx 6589 17 were be VBD cord-010092-uftc8inx 6589 18 analyzed analyze VBN cord-010092-uftc8inx 6589 19 . . . cord-010092-uftc8inx 6590 1 Platelets platelet NNS cord-010092-uftc8inx 6590 2 were be VBD cord-010092-uftc8inx 6590 3 tested test VBN cord-010092-uftc8inx 6590 4 on on IN cord-010092-uftc8inx 6590 5 day day NN cord-010092-uftc8inx 6590 6 3 3 CD cord-010092-uftc8inx 6590 7 , , , cord-010092-uftc8inx 6590 8 4 4 CD cord-010092-uftc8inx 6590 9 , , , cord-010092-uftc8inx 6590 10 or or CC cord-010092-uftc8inx 6590 11 ≥ ≥ CD cord-010092-uftc8inx 6590 12 6 6 CD cord-010092-uftc8inx 6590 13 , , , cord-010092-uftc8inx 6590 14 and and CC cord-010092-uftc8inx 6590 15 represented represent VBD cord-010092-uftc8inx 6590 16 8.9 8.9 CD cord-010092-uftc8inx 6590 17 % % NN cord-010092-uftc8inx 6590 18 , , , cord-010092-uftc8inx 6590 19 44 44 CD cord-010092-uftc8inx 6590 20 % % NN cord-010092-uftc8inx 6590 21 , , , cord-010092-uftc8inx 6590 22 and and CC cord-010092-uftc8inx 6590 23 47 47 CD cord-010092-uftc8inx 6590 24 % % NN cord-010092-uftc8inx 6590 25 of of IN cord-010092-uftc8inx 6590 26 the the DT cord-010092-uftc8inx 6590 27 units unit NNS cord-010092-uftc8inx 6590 28 tested test VBN cord-010092-uftc8inx 6590 29 , , , cord-010092-uftc8inx 6590 30 respectively respectively RB cord-010092-uftc8inx 6590 31 . . . cord-010092-uftc8inx 6591 1 True true JJ cord-010092-uftc8inx 6591 2 positives positive NNS cord-010092-uftc8inx 6591 3 were be VBD cord-010092-uftc8inx 6591 4 detected detect VBN cord-010092-uftc8inx 6591 5 in in IN cord-010092-uftc8inx 6591 6 174 174 CD cord-010092-uftc8inx 6591 7 platelet platelet NN cord-010092-uftc8inx 6591 8 units unit NNS cord-010092-uftc8inx 6591 9 representing represent VBG cord-010092-uftc8inx 6591 10 0.08 0.08 CD cord-010092-uftc8inx 6591 11 % % NN cord-010092-uftc8inx 6591 12 of of IN cord-010092-uftc8inx 6591 13 the the DT cord-010092-uftc8inx 6591 14 total total JJ cord-010092-uftc8inx 6591 15 platelets platelet NNS cord-010092-uftc8inx 6591 16 tested test VBN cord-010092-uftc8inx 6591 17 . . . cord-010092-uftc8inx 6592 1 The the DT cord-010092-uftc8inx 6592 2 majority majority NN cord-010092-uftc8inx 6592 3 were be VBD cord-010092-uftc8inx 6592 4 reported report VBN cord-010092-uftc8inx 6592 5 from from IN cord-010092-uftc8inx 6592 6 platelets platelet NNS cord-010092-uftc8inx 6592 7 tested test VBN cord-010092-uftc8inx 6592 8 on on IN cord-010092-uftc8inx 6592 9 day day NN cord-010092-uftc8inx 6592 10 ≥ ≥ CD cord-010092-uftc8inx 6592 11 6 6 CD cord-010092-uftc8inx 6592 12 with with IN cord-010092-uftc8inx 6592 13 a a DT cord-010092-uftc8inx 6592 14 total total NN cord-010092-uftc8inx 6592 15 of of IN cord-010092-uftc8inx 6592 16 128 128 CD cord-010092-uftc8inx 6592 17 . . . cord-010092-uftc8inx 6593 1 Data datum NNS cord-010092-uftc8inx 6593 2 showed show VBD cord-010092-uftc8inx 6593 3 the the DT cord-010092-uftc8inx 6593 4 BTA BTA NNP cord-010092-uftc8inx 6593 5 3D 3D NNP cord-010092-uftc8inx 6593 6 System System NNP cord-010092-uftc8inx 6593 7 used use VBD cord-010092-uftc8inx 6593 8 for for IN cord-010092-uftc8inx 6593 9 secondary secondary JJ cord-010092-uftc8inx 6593 10 testing testing NN cord-010092-uftc8inx 6593 11 detects detect VBZ cord-010092-uftc8inx 6593 12 the the DT cord-010092-uftc8inx 6593 13 most most RBS cord-010092-uftc8inx 6593 14 prevalent prevalent JJ cord-010092-uftc8inx 6593 15 contaminates contaminate NNS cord-010092-uftc8inx 6593 16 reported report VBN cord-010092-uftc8inx 6593 17 , , , cord-010092-uftc8inx 6593 18 Staphylococcus Staphylococcus NNP cord-010092-uftc8inx 6593 19 spp spp NNS cord-010092-uftc8inx 6593 20 . . . cord-010092-uftc8inx 6594 1 , , , cord-010092-uftc8inx 6594 2 in in IN cord-010092-uftc8inx 6594 3 ≤27 ≤27 NN cord-010092-uftc8inx 6595 1 h h NNP cord-010092-uftc8inx 6595 2 with with IN cord-010092-uftc8inx 6595 3 the the DT cord-010092-uftc8inx 6595 4 majority majority NN cord-010092-uftc8inx 6595 5 detected detect VBN cord-010092-uftc8inx 6595 6 in in IN cord-010092-uftc8inx 6595 7 ≤24 ≤24 NNP cord-010092-uftc8inx 6595 8 h h NN cord-010092-uftc8inx 6595 9 after after IN cord-010092-uftc8inx 6595 10 incubation incubation NN cord-010092-uftc8inx 6595 11 , , , cord-010092-uftc8inx 6595 12 allowing allow VBG cord-010092-uftc8inx 6595 13 for for IN cord-010092-uftc8inx 6595 14 interdiction interdiction NN cord-010092-uftc8inx 6595 15 of of IN cord-010092-uftc8inx 6595 16 the the DT cord-010092-uftc8inx 6595 17 units unit NNS cord-010092-uftc8inx 6595 18 prior prior RB cord-010092-uftc8inx 6595 19 to to IN cord-010092-uftc8inx 6595 20 transfusion transfusion NN cord-010092-uftc8inx 6595 21 . . . cord-010092-uftc8inx 6596 1 Instrument instrument NN cord-010092-uftc8inx 6596 2 specificity specificity NN cord-010092-uftc8inx 6596 3 was be VBD cord-010092-uftc8inx 6596 4 reported report VBN cord-010092-uftc8inx 6596 5 in in IN cord-010092-uftc8inx 6596 6 5 5 CD cord-010092-uftc8inx 6596 7 of of IN cord-010092-uftc8inx 6596 8 the the DT cord-010092-uftc8inx 6596 9 11 11 CD cord-010092-uftc8inx 6596 10 studies study NNS cord-010092-uftc8inx 6596 11 for for IN cord-010092-uftc8inx 6596 12 platelets platelet NNS cord-010092-uftc8inx 6596 13 tested test VBN cord-010092-uftc8inx 6596 14 at at IN cord-010092-uftc8inx 6596 15 3 3 CD cord-010092-uftc8inx 6596 16 days day NNS cord-010092-uftc8inx 6596 17 and and CC cord-010092-uftc8inx 6596 18 ≥ ≥ CD cord-010092-uftc8inx 6596 19 6 6 CD cord-010092-uftc8inx 6596 20 days day NNS cord-010092-uftc8inx 6596 21 with with IN cord-010092-uftc8inx 6596 22 a a DT cord-010092-uftc8inx 6596 23 total total JJ cord-010092-uftc8inx 6596 24 false false JJ cord-010092-uftc8inx 6596 25 positive positive JJ cord-010092-uftc8inx 6596 26 rate rate NN cord-010092-uftc8inx 6596 27 of of IN cord-010092-uftc8inx 6596 28 0.27 0.27 CD cord-010092-uftc8inx 6596 29 % % NN cord-010092-uftc8inx 6596 30 ( ( -LRB- cord-010092-uftc8inx 6596 31 range range NN cord-010092-uftc8inx 6596 32 of of IN cord-010092-uftc8inx 6596 33 0 0 CD cord-010092-uftc8inx 6596 34 - - SYM cord-010092-uftc8inx 6596 35 1.1 1.1 CD cord-010092-uftc8inx 6596 36 % % NN cord-010092-uftc8inx 6596 37 ) ) -RRB- cord-010092-uftc8inx 6596 38 . . . cord-010092-uftc8inx 6597 1 Instrument instrument NN cord-010092-uftc8inx 6597 2 sensitivity sensitivity NN cord-010092-uftc8inx 6597 3 when when WRB cord-010092-uftc8inx 6597 4 used use VBN cord-010092-uftc8inx 6597 5 for for IN cord-010092-uftc8inx 6597 6 secondary secondary JJ cord-010092-uftc8inx 6597 7 testing testing NN cord-010092-uftc8inx 6597 8 could could MD cord-010092-uftc8inx 6597 9 not not RB cord-010092-uftc8inx 6597 10 be be VB cord-010092-uftc8inx 6597 11 determined determine VBN cord-010092-uftc8inx 6597 12 since since IN cord-010092-uftc8inx 6597 13 subculture subculture NN cord-010092-uftc8inx 6597 14 of of IN cord-010092-uftc8inx 6597 15 negative negative JJ cord-010092-uftc8inx 6597 16 bottles bottle NNS cord-010092-uftc8inx 6597 17 is be VBZ cord-010092-uftc8inx 6597 18 not not RB cord-010092-uftc8inx 6597 19 performed perform VBN cord-010092-uftc8inx 6597 20 during during IN cord-010092-uftc8inx 6597 21 routine routine JJ cord-010092-uftc8inx 6597 22 use use NN cord-010092-uftc8inx 6597 23 . . . cord-010092-uftc8inx 6598 1 During during IN cord-010092-uftc8inx 6598 2 previous previous JJ cord-010092-uftc8inx 6598 3 validation validation NN cord-010092-uftc8inx 6598 4 testing testing NN cord-010092-uftc8inx 6598 5 of of IN cord-010092-uftc8inx 6598 6 LRAP LRAP NNP cord-010092-uftc8inx 6598 7 and and CC cord-010092-uftc8inx 6598 8 LRWBPC LRWBPC NNP cord-010092-uftc8inx 6598 9 , , , cord-010092-uftc8inx 6598 10 1,136 1,136 CD cord-010092-uftc8inx 6598 11 culture culture NN cord-010092-uftc8inx 6598 12 bottles bottle NNS cord-010092-uftc8inx 6598 13 were be VBD cord-010092-uftc8inx 6598 14 confirmed confirm VBN cord-010092-uftc8inx 6598 15 true true JJ cord-010092-uftc8inx 6598 16 negatives negative NNS cord-010092-uftc8inx 6598 17 by by IN cord-010092-uftc8inx 6598 18 subculture subculture NN cord-010092-uftc8inx 6598 19 . . . cord-010092-uftc8inx 6599 1 Summary Summary NNP cord-010092-uftc8inx 6599 2 / / SYM cord-010092-uftc8inx 6599 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 6599 4 : : : cord-010092-uftc8inx 6600 1 Data datum NNS cord-010092-uftc8inx 6600 2 from from IN cord-010092-uftc8inx 6600 3 the the DT cord-010092-uftc8inx 6600 4 studies study NNS cord-010092-uftc8inx 6600 5 that that WDT cord-010092-uftc8inx 6600 6 tested test VBD cord-010092-uftc8inx 6600 7 platelets platelet NNS cord-010092-uftc8inx 6600 8 at at IN cord-010092-uftc8inx 6600 9 3 3 CD cord-010092-uftc8inx 6600 10 to to TO cord-010092-uftc8inx 6600 11 8 8 CD cord-010092-uftc8inx 6600 12 days day NNS cord-010092-uftc8inx 6600 13 post post NN cord-010092-uftc8inx 6600 14 collection collection NN cord-010092-uftc8inx 6600 15 provided provide VBD cord-010092-uftc8inx 6600 16 evidence evidence NN cord-010092-uftc8inx 6600 17 that that IN cord-010092-uftc8inx 6600 18 the the DT cord-010092-uftc8inx 6600 19 BTA BTA NNP cord-010092-uftc8inx 6600 20 3D 3d NN cord-010092-uftc8inx 6600 21 with with IN cord-010092-uftc8inx 6600 22 BPA BPA NNP cord-010092-uftc8inx 6600 23 & & CC cord-010092-uftc8inx 6600 24 BPN BPN NNP cord-010092-uftc8inx 6600 25 detects detect VBZ cord-010092-uftc8inx 6600 26 contaminants contaminant NNS cord-010092-uftc8inx 6600 27 missed miss VBN cord-010092-uftc8inx 6600 28 in in IN cord-010092-uftc8inx 6600 29 previously previously RB cord-010092-uftc8inx 6600 30 tested test VBN cord-010092-uftc8inx 6600 31 platelet platelet NN cord-010092-uftc8inx 6600 32 units unit NNS cord-010092-uftc8inx 6600 33 . . . cord-010092-uftc8inx 6601 1 The the DT cord-010092-uftc8inx 6601 2 data data NN cord-010092-uftc8inx 6601 3 supports support VBZ cord-010092-uftc8inx 6601 4 that that IN cord-010092-uftc8inx 6601 5 the the DT cord-010092-uftc8inx 6601 6 BACT BACT NNP cord-010092-uftc8inx 6601 7 / / SYM cord-010092-uftc8inx 6601 8 ALERT ALERT NNP cord-010092-uftc8inx 6601 9 3D 3D NNP cord-010092-uftc8inx 6601 10 System System NNP cord-010092-uftc8inx 6601 11 is be VBZ cord-010092-uftc8inx 6601 12 an an DT cord-010092-uftc8inx 6601 13 effective effective JJ cord-010092-uftc8inx 6601 14 safety safety NN cord-010092-uftc8inx 6601 15 measure measure NN cord-010092-uftc8inx 6601 16 for for IN cord-010092-uftc8inx 6601 17 secondary secondary JJ cord-010092-uftc8inx 6601 18 testing testing NN cord-010092-uftc8inx 6601 19 of of IN cord-010092-uftc8inx 6601 20 platelet platelet NN cord-010092-uftc8inx 6601 21 products product NNS cord-010092-uftc8inx 6601 22 to to TO cord-010092-uftc8inx 6601 23 extend extend VB cord-010092-uftc8inx 6601 24 platelet platelet NN cord-010092-uftc8inx 6601 25 dating date VBG cord-010092-uftc8inx 6601 26 beyond beyond IN cord-010092-uftc8inx 6601 27 day day NN cord-010092-uftc8inx 6601 28 3 3 CD cord-010092-uftc8inx 6601 29 and and CC cord-010092-uftc8inx 6601 30 up up IN cord-010092-uftc8inx 6601 31 to to IN cord-010092-uftc8inx 6601 32 day day NN cord-010092-uftc8inx 6601 33 7 7 CD cord-010092-uftc8inx 6601 34 when when WRB cord-010092-uftc8inx 6601 35 testing testing NN cord-010092-uftc8inx 6601 36 is be VBZ cord-010092-uftc8inx 6601 37 performed perform VBN cord-010092-uftc8inx 6601 38 using use VBG cord-010092-uftc8inx 6601 39 the the DT cord-010092-uftc8inx 6601 40 test test NN cord-010092-uftc8inx 6601 41 parameters parameter NNS cord-010092-uftc8inx 6601 42 described describe VBN cord-010092-uftc8inx 6601 43 in in IN cord-010092-uftc8inx 6601 44 the the DT cord-010092-uftc8inx 6601 45 BPA BPA NNP cord-010092-uftc8inx 6601 46 and and CC cord-010092-uftc8inx 6601 47 BPN BPN NNP cord-010092-uftc8inx 6601 48 bottle bottle NN cord-010092-uftc8inx 6601 49 IFUs ifus NN cord-010092-uftc8inx 6601 50 and and CC cord-010092-uftc8inx 6601 51 according accord VBG cord-010092-uftc8inx 6601 52 to to IN cord-010092-uftc8inx 6601 53 the the DT cord-010092-uftc8inx 6601 54 FDA FDA NNP cord-010092-uftc8inx 6601 55 Draft Draft NNP cord-010092-uftc8inx 6601 56 Guidance Guidance NNP cord-010092-uftc8inx 6601 57 . . . cord-010092-uftc8inx 6602 1 Background background NN cord-010092-uftc8inx 6602 2 : : : cord-010092-uftc8inx 6603 1 Magnetic magnetic JJ cord-010092-uftc8inx 6603 2 nanoparticles nanoparticle NNS cord-010092-uftc8inx 6603 3 have have VBP cord-010092-uftc8inx 6603 4 recently recently RB cord-010092-uftc8inx 6603 5 shown show VBN cord-010092-uftc8inx 6603 6 great great JJ cord-010092-uftc8inx 6603 7 potential potential NN cord-010092-uftc8inx 6603 8 in in IN cord-010092-uftc8inx 6603 9 nonradioactive nonradioactive JJ cord-010092-uftc8inx 6603 10 labeling labeling NN cord-010092-uftc8inx 6603 11 of of IN cord-010092-uftc8inx 6603 12 platelets platelet NNS cord-010092-uftc8inx 6603 13 . . . cord-010092-uftc8inx 6604 1 Platelet platelet NN cord-010092-uftc8inx 6604 2 labeling labeling NN cord-010092-uftc8inx 6604 3 efficiency efficiency NN cord-010092-uftc8inx 6604 4 is be VBZ cord-010092-uftc8inx 6604 5 enhanced enhance VBN cord-010092-uftc8inx 6604 6 when when WRB cord-010092-uftc8inx 6604 7 particles particle NNS cord-010092-uftc8inx 6604 8 are be VBP cord-010092-uftc8inx 6604 9 conjugated conjugate VBN cord-010092-uftc8inx 6604 10 with with IN cord-010092-uftc8inx 6604 11 proteins protein NNS cord-010092-uftc8inx 6604 12 like like IN cord-010092-uftc8inx 6604 13 human human JJ cord-010092-uftc8inx 6604 14 serum serum NN cord-010092-uftc8inx 6604 15 albumin albumin NN cord-010092-uftc8inx 6604 16 ( ( -LRB- cord-010092-uftc8inx 6604 17 HSA HSA NNP cord-010092-uftc8inx 6604 18 ) ) -RRB- cord-010092-uftc8inx 6604 19 . . . cord-010092-uftc8inx 6605 1 However however RB cord-010092-uftc8inx 6605 2 , , , cord-010092-uftc8inx 6605 3 the the DT cord-010092-uftc8inx 6605 4 optimal optimal JJ cord-010092-uftc8inx 6605 5 HSA HSA NNP cord-010092-uftc8inx 6605 6 density density NN cord-010092-uftc8inx 6605 7 coated coat VBN cord-010092-uftc8inx 6605 8 on on IN cord-010092-uftc8inx 6605 9 particles particle NNS cord-010092-uftc8inx 6605 10 and and CC cord-010092-uftc8inx 6605 11 the the DT cord-010092-uftc8inx 6605 12 uptake uptake NN cord-010092-uftc8inx 6605 13 mechanism mechanism NN cord-010092-uftc8inx 6605 14 of of IN cord-010092-uftc8inx 6605 15 single single JJ cord-010092-uftc8inx 6605 16 particles particle NNS cord-010092-uftc8inx 6605 17 in in IN cord-010092-uftc8inx 6605 18 platelets platelet NNS cord-010092-uftc8inx 6605 19 remain remain VBP cord-010092-uftc8inx 6605 20 unclear unclear JJ cord-010092-uftc8inx 6605 21 . . . cord-010092-uftc8inx 6606 1 Aims aim VBZ cord-010092-uftc8inx 6606 2 : : : cord-010092-uftc8inx 6607 1 We -PRON- PRP cord-010092-uftc8inx 6607 2 characterize characterize VBP cord-010092-uftc8inx 6607 3 the the DT cord-010092-uftc8inx 6607 4 interaction interaction NN cord-010092-uftc8inx 6607 5 between between IN cord-010092-uftc8inx 6607 6 single single JJ cord-010092-uftc8inx 6607 7 particles particle NNS cord-010092-uftc8inx 6607 8 and and CC cord-010092-uftc8inx 6607 9 platelets platelet NNS cord-010092-uftc8inx 6607 10 and and CC cord-010092-uftc8inx 6607 11 determine determine VB cord-010092-uftc8inx 6607 12 the the DT cord-010092-uftc8inx 6607 13 optimal optimal JJ cord-010092-uftc8inx 6607 14 HSA HSA NNP cord-010092-uftc8inx 6607 15 amount amount NN cord-010092-uftc8inx 6607 16 required require VBN cord-010092-uftc8inx 6607 17 to to IN cord-010092-uftc8inx 6607 18 coat coat NN cord-010092-uftc8inx 6607 19 particles particle NNS cord-010092-uftc8inx 6607 20 . . . cord-010092-uftc8inx 6608 1 Methods method NNS cord-010092-uftc8inx 6608 2 : : : cord-010092-uftc8inx 6608 3 Ferucarbotran ferucarbotran NN cord-010092-uftc8inx 6608 4 iron iron NN cord-010092-uftc8inx 6608 5 oxide oxide NN cord-010092-uftc8inx 6608 6 nanoparticles nanoparticle NNS cord-010092-uftc8inx 6608 7 were be VBD cord-010092-uftc8inx 6608 8 coated coat VBN cord-010092-uftc8inx 6608 9 with with IN cord-010092-uftc8inx 6608 10 HSA HSA NNP cord-010092-uftc8inx 6608 11 in in IN cord-010092-uftc8inx 6608 12 different different JJ cord-010092-uftc8inx 6608 13 amounts amount NNS cord-010092-uftc8inx 6608 14 ( ( -LRB- cord-010092-uftc8inx 6608 15 0.5 0.5 CD cord-010092-uftc8inx 6608 16 - - SYM cord-010092-uftc8inx 6608 17 2 2 CD cord-010092-uftc8inx 6608 18 mg mg NNP cord-010092-uftc8inx 6608 19 / / SYM cord-010092-uftc8inx 6608 20 mL mL NNP cord-010092-uftc8inx 6608 21 ) ) -RRB- cord-010092-uftc8inx 6608 22 and and CC cord-010092-uftc8inx 6608 23 we -PRON- PRP cord-010092-uftc8inx 6608 24 confirmed confirm VBD cord-010092-uftc8inx 6608 25 successful successful JJ cord-010092-uftc8inx 6608 26 HSA HSA NNP cord-010092-uftc8inx 6608 27 coating coating NN cord-010092-uftc8inx 6608 28 by by IN cord-010092-uftc8inx 6608 29 addition addition NN cord-010092-uftc8inx 6608 30 of of IN cord-010092-uftc8inx 6608 31 a a DT cord-010092-uftc8inx 6608 32 crosslinking crosslinke VBG cord-010092-uftc8inx 6608 33 HSA HSA NNP cord-010092-uftc8inx 6608 34 antibody antibody NN cord-010092-uftc8inx 6608 35 ( ( -LRB- cord-010092-uftc8inx 6608 36 dynamic dynamic JJ cord-010092-uftc8inx 6608 37 light light JJ cord-010092-uftc8inx 6608 38 scattering scattering NN cord-010092-uftc8inx 6608 39 ) ) -RRB- cord-010092-uftc8inx 6608 40 . . . cord-010092-uftc8inx 6609 1 We -PRON- PRP cord-010092-uftc8inx 6609 2 labeled label VBD cord-010092-uftc8inx 6609 3 platelets platelet NNS cord-010092-uftc8inx 6609 4 from from IN cord-010092-uftc8inx 6609 5 pooled pool VBN cord-010092-uftc8inx 6609 6 platelet platelet NN cord-010092-uftc8inx 6609 7 concentrates concentrate VBZ cord-010092-uftc8inx 6609 8 with with IN cord-010092-uftc8inx 6609 9 2 2 CD cord-010092-uftc8inx 6609 10 mM mm NN cord-010092-uftc8inx 6609 11 ferucarbotran ferucarbotran NN cord-010092-uftc8inx 6609 12 coated coat VBN cord-010092-uftc8inx 6609 13 nanoparticles nanoparticle NNS cord-010092-uftc8inx 6609 14 and and CC cord-010092-uftc8inx 6609 15 analyzed analyze VBD cord-010092-uftc8inx 6609 16 labeled label VBN cord-010092-uftc8inx 6609 17 platelets platelet NNS cord-010092-uftc8inx 6609 18 for for IN cord-010092-uftc8inx 6609 19 iron iron NN cord-010092-uftc8inx 6609 20 content content NN cord-010092-uftc8inx 6609 21 ( ( -LRB- cord-010092-uftc8inx 6609 22 atomic atomic JJ cord-010092-uftc8inx 6609 23 absorption absorption NN cord-010092-uftc8inx 6609 24 spectroscopy spectroscopy NN cord-010092-uftc8inx 6609 25 ) ) -RRB- cord-010092-uftc8inx 6609 26 and and CC cord-010092-uftc8inx 6609 27 particle particle NN cord-010092-uftc8inx 6609 28 localization localization NN cord-010092-uftc8inx 6609 29 ( ( -LRB- cord-010092-uftc8inx 6609 30 transmission transmission NN cord-010092-uftc8inx 6609 31 electron electron NN cord-010092-uftc8inx 6609 32 microscopy microscopy NN cord-010092-uftc8inx 6609 33 ) ) -RRB- cord-010092-uftc8inx 6609 34 . . . cord-010092-uftc8inx 6610 1 Single single JJ cord-010092-uftc8inx 6610 2 - - HYPH cord-010092-uftc8inx 6610 3 molecule molecule NN cord-010092-uftc8inx 6610 4 force force NN cord-010092-uftc8inx 6610 5 spectroscopy spectroscopy NN cord-010092-uftc8inx 6610 6 was be VBD cord-010092-uftc8inx 6610 7 used use VBN cord-010092-uftc8inx 6610 8 to to TO cord-010092-uftc8inx 6610 9 determine determine VB cord-010092-uftc8inx 6610 10 binding bind VBG cord-010092-uftc8inx 6610 11 forces force NNS cord-010092-uftc8inx 6610 12 of of IN cord-010092-uftc8inx 6610 13 nanoparticles nanoparticle NNS cord-010092-uftc8inx 6610 14 to to IN cord-010092-uftc8inx 6610 15 platelet platelet NN cord-010092-uftc8inx 6610 16 compartments compartment NNS cord-010092-uftc8inx 6610 17 . . . cord-010092-uftc8inx 6611 1 We -PRON- PRP cord-010092-uftc8inx 6611 2 applied apply VBD cord-010092-uftc8inx 6611 3 HSA HSA NNP cord-010092-uftc8inx 6611 4 - - HYPH cord-010092-uftc8inx 6611 5 particles particle NNS cord-010092-uftc8inx 6611 6 via via IN cord-010092-uftc8inx 6611 7 linkers linker NNS cord-010092-uftc8inx 6611 8 of of IN cord-010092-uftc8inx 6611 9 different different JJ cord-010092-uftc8inx 6611 10 length length NN cord-010092-uftc8inx 6611 11 ( ( -LRB- cord-010092-uftc8inx 6611 12 i.e. i.e. FW cord-010092-uftc8inx 6611 13 short~2 short~2 NNP cord-010092-uftc8inx 6611 14 nm nm NN cord-010092-uftc8inx 6611 15 , , , cord-010092-uftc8inx 6611 16 medium medium JJ cord-010092-uftc8inx 6611 17 30 30 CD cord-010092-uftc8inx 6611 18 nm nm NN cord-010092-uftc8inx 6611 19 and and CC cord-010092-uftc8inx 6611 20 long~100 long~100 NNP cord-010092-uftc8inx 6611 21 nm nm LS cord-010092-uftc8inx 6611 22 ) ) -RRB- cord-010092-uftc8inx 6611 23 on on IN cord-010092-uftc8inx 6611 24 the the DT cord-010092-uftc8inx 6611 25 cantilever cantilever JJ cord-010092-uftc8inx 6611 26 tip tip NN cord-010092-uftc8inx 6611 27 and and CC cord-010092-uftc8inx 6611 28 let let VB cord-010092-uftc8inx 6611 29 them -PRON- PRP cord-010092-uftc8inx 6611 30 interact interact VB cord-010092-uftc8inx 6611 31 with with IN cord-010092-uftc8inx 6611 32 a a DT cord-010092-uftc8inx 6611 33 platelet platelet NN cord-010092-uftc8inx 6611 34 provided provide VBN cord-010092-uftc8inx 6611 35 on on IN cord-010092-uftc8inx 6611 36 a a DT cord-010092-uftc8inx 6611 37 collagen collagen NN cord-010092-uftc8inx 6611 38 surface surface NN cord-010092-uftc8inx 6611 39 . . . cord-010092-uftc8inx 6612 1 After after IN cord-010092-uftc8inx 6612 2 interaction interaction NN cord-010092-uftc8inx 6612 3 we -PRON- PRP cord-010092-uftc8inx 6612 4 determined determine VBD cord-010092-uftc8inx 6612 5 the the DT cord-010092-uftc8inx 6612 6 rupture rupture NN cord-010092-uftc8inx 6612 7 force force NN cord-010092-uftc8inx 6612 8 required require VBN cord-010092-uftc8inx 6612 9 for for IN cord-010092-uftc8inx 6612 10 platelet platelet NN cord-010092-uftc8inx 6612 11 retrieval retrieval NN cord-010092-uftc8inx 6612 12 . . . cord-010092-uftc8inx 6613 1 Results result NNS cord-010092-uftc8inx 6613 2 : : : cord-010092-uftc8inx 6614 1 The the DT cord-010092-uftc8inx 6614 2 iron iron NN cord-010092-uftc8inx 6614 3 content content NN cord-010092-uftc8inx 6614 4 per per IN cord-010092-uftc8inx 6614 5 platelet platelet NN cord-010092-uftc8inx 6614 6 reached reach VBD cord-010092-uftc8inx 6614 7 a a DT cord-010092-uftc8inx 6614 8 maximum maximum NN cord-010092-uftc8inx 6614 9 at at IN cord-010092-uftc8inx 6614 10 0.5 0.5 CD cord-010092-uftc8inx 6614 11 - - SYM cord-010092-uftc8inx 6614 12 1.0 1.0 CD cord-010092-uftc8inx 6614 13 mg mg NN cord-010092-uftc8inx 6614 14 / / SYM cord-010092-uftc8inx 6614 15 mL mL NNP cord-010092-uftc8inx 6614 16 HSA HSA NNP cord-010092-uftc8inx 6614 17 coated coat VBN cord-010092-uftc8inx 6614 18 particles particle NNS cord-010092-uftc8inx 6614 19 with with IN cord-010092-uftc8inx 6614 20 0.57 0.57 CD cord-010092-uftc8inx 6614 21 AE AE NNP cord-010092-uftc8inx 6614 22 0.36 0.36 CD cord-010092-uftc8inx 6614 23 and and CC cord-010092-uftc8inx 6614 24 0.54 0.54 CD cord-010092-uftc8inx 6614 25 AE AE NNP cord-010092-uftc8inx 6614 26 0.39 0.39 CD cord-010092-uftc8inx 6614 27 pg pg NN cord-010092-uftc8inx 6614 28 / / SYM cord-010092-uftc8inx 6614 29 platelet platelet NN cord-010092-uftc8inx 6614 30 , , , cord-010092-uftc8inx 6614 31 respectively respectively RB cord-010092-uftc8inx 6614 32 . . . cord-010092-uftc8inx 6615 1 However however RB cord-010092-uftc8inx 6615 2 , , , cord-010092-uftc8inx 6615 3 the the DT cord-010092-uftc8inx 6615 4 1.0 1.0 CD cord-010092-uftc8inx 6615 5 mg mg NNP cord-010092-uftc8inx 6615 6 / / SYM cord-010092-uftc8inx 6615 7 mL mL NNP cord-010092-uftc8inx 6615 8 HSA HSA NNP cord-010092-uftc8inx 6615 9 coating coating NN cord-010092-uftc8inx 6615 10 resulted result VBD cord-010092-uftc8inx 6615 11 in~100-fold in~100-fold JJ cord-010092-uftc8inx 6615 12 higher high JJR cord-010092-uftc8inx 6615 13 binding bind VBG cord-010092-uftc8inx 6615 14 affinity affinity NN cord-010092-uftc8inx 6615 15 to to IN cord-010092-uftc8inx 6615 16 platelets platelet NNS cord-010092-uftc8inx 6615 17 than than IN cord-010092-uftc8inx 6615 18 particles particle NNS cord-010092-uftc8inx 6615 19 coated coat VBN cord-010092-uftc8inx 6615 20 with with IN cord-010092-uftc8inx 6615 21 0.5 0.5 CD cord-010092-uftc8inx 6615 22 mg mg NNP cord-010092-uftc8inx 6615 23 / / SYM cord-010092-uftc8inx 6615 24 mL mL NNP cord-010092-uftc8inx 6615 25 HSA HSA NNP cord-010092-uftc8inx 6615 26 . . . cord-010092-uftc8inx 6616 1 Depending depend VBG cord-010092-uftc8inx 6616 2 on on IN cord-010092-uftc8inx 6616 3 PEG PEG NNP cord-010092-uftc8inx 6616 4 length length NN cord-010092-uftc8inx 6616 5 between between IN cord-010092-uftc8inx 6616 6 tip tip NN cord-010092-uftc8inx 6616 7 and and CC cord-010092-uftc8inx 6616 8 particle particle NN cord-010092-uftc8inx 6616 9 , , , cord-010092-uftc8inx 6616 10 particles particle NNS cord-010092-uftc8inx 6616 11 interacted interact VBN cord-010092-uftc8inx 6616 12 differently differently RB cord-010092-uftc8inx 6616 13 with with IN cord-010092-uftc8inx 6616 14 platelets platelet NNS cord-010092-uftc8inx 6616 15 as as IN cord-010092-uftc8inx 6616 16 shown show VBN cord-010092-uftc8inx 6616 17 by by IN cord-010092-uftc8inx 6616 18 one one CD cord-010092-uftc8inx 6616 19 , , , cord-010092-uftc8inx 6616 20 two two CD cord-010092-uftc8inx 6616 21 or or CC cord-010092-uftc8inx 6616 22 three three CD cord-010092-uftc8inx 6616 23 force force NN cord-010092-uftc8inx 6616 24 distributions distribution NNS cord-010092-uftc8inx 6616 25 of of IN cord-010092-uftc8inx 6616 26 80 80 CD cord-010092-uftc8inx 6616 27 , , , cord-010092-uftc8inx 6616 28 220 220 CD cord-010092-uftc8inx 6616 29 , , , cord-010092-uftc8inx 6616 30 and and CC cord-010092-uftc8inx 6616 31 360 360 CD cord-010092-uftc8inx 6616 32 pN pn NN cord-010092-uftc8inx 6616 33 , , , cord-010092-uftc8inx 6616 34 which which WDT cord-010092-uftc8inx 6616 35 correspond correspond VBP cord-010092-uftc8inx 6616 36 up up RP cord-010092-uftc8inx 6616 37 to to TO cord-010092-uftc8inx 6616 38 three three CD cord-010092-uftc8inx 6616 39 different different JJ cord-010092-uftc8inx 6616 40 binding bind VBG cord-010092-uftc8inx 6616 41 pathways pathway NNS cord-010092-uftc8inx 6616 42 , , , cord-010092-uftc8inx 6616 43 respectively respectively RB cord-010092-uftc8inx 6616 44 . . . cord-010092-uftc8inx 6617 1 The the DT cord-010092-uftc8inx 6617 2 results result NNS cord-010092-uftc8inx 6617 3 indicate indicate VBP cord-010092-uftc8inx 6617 4 that that IN cord-010092-uftc8inx 6617 5 a a DT cord-010092-uftc8inx 6617 6 particle particle NN cord-010092-uftc8inx 6617 7 can can MD cord-010092-uftc8inx 6617 8 interact interact VB cord-010092-uftc8inx 6617 9 with with IN cord-010092-uftc8inx 6617 10 three three CD cord-010092-uftc8inx 6617 11 targets target NNS cord-010092-uftc8inx 6617 12 including include VBG cord-010092-uftc8inx 6617 13 platelet platelet NN cord-010092-uftc8inx 6617 14 membrane membrane NN cord-010092-uftc8inx 6617 15 , , , cord-010092-uftc8inx 6617 16 open open JJ cord-010092-uftc8inx 6617 17 canalicular canalicular JJ cord-010092-uftc8inx 6617 18 system system NN cord-010092-uftc8inx 6617 19 , , , cord-010092-uftc8inx 6617 20 and and CC cord-010092-uftc8inx 6617 21 platelet platelet NN cord-010092-uftc8inx 6617 22 granules granule NNS cord-010092-uftc8inx 6617 23 . . . cord-010092-uftc8inx 6618 1 Summary Summary NNP cord-010092-uftc8inx 6618 2 / / SYM cord-010092-uftc8inx 6618 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 6618 4 : : : cord-010092-uftc8inx 6619 1 Our -PRON- PRP$ cord-010092-uftc8inx 6619 2 results result NNS cord-010092-uftc8inx 6619 3 reveal reveal VBP cord-010092-uftc8inx 6619 4 mechanism mechanism NN cord-010092-uftc8inx 6619 5 of of IN cord-010092-uftc8inx 6619 6 platelet platelet NN cord-010092-uftc8inx 6619 7 - - HYPH cord-010092-uftc8inx 6619 8 particle particle NN cord-010092-uftc8inx 6619 9 interaction interaction NN cord-010092-uftc8inx 6619 10 on on IN cord-010092-uftc8inx 6619 11 a a DT cord-010092-uftc8inx 6619 12 single single JJ cord-010092-uftc8inx 6619 13 particle particle NN cord-010092-uftc8inx 6619 14 level level NN cord-010092-uftc8inx 6619 15 and and CC cord-010092-uftc8inx 6619 16 provide provide VB cord-010092-uftc8inx 6619 17 an an DT cord-010092-uftc8inx 6619 18 optimal optimal JJ cord-010092-uftc8inx 6619 19 HSA HSA NNP cord-010092-uftc8inx 6619 20 concentration concentration NN cord-010092-uftc8inx 6619 21 coated coat VBN cord-010092-uftc8inx 6619 22 on on IN cord-010092-uftc8inx 6619 23 particles particle NNS cord-010092-uftc8inx 6619 24 to to TO cord-010092-uftc8inx 6619 25 gain gain VB cord-010092-uftc8inx 6619 26 maximal maximal JJ cord-010092-uftc8inx 6619 27 platelet platelet NN cord-010092-uftc8inx 6619 28 labeling labeling NN cord-010092-uftc8inx 6619 29 efficiency efficiency NN cord-010092-uftc8inx 6619 30 . . . cord-010092-uftc8inx 6620 1 Labelling labelling NN cord-010092-uftc8inx 6620 2 of of IN cord-010092-uftc8inx 6620 3 platelets platelet NNS cord-010092-uftc8inx 6620 4 by by IN cord-010092-uftc8inx 6620 5 magnetic magnetic JJ cord-010092-uftc8inx 6620 6 nanoparticles nanoparticle NNS cord-010092-uftc8inx 6620 7 may may MD cord-010092-uftc8inx 6620 8 substitute substitute VB cord-010092-uftc8inx 6620 9 radioactive radioactive JJ cord-010092-uftc8inx 6620 10 labeling labeling NN cord-010092-uftc8inx 6620 11 . . . cord-010092-uftc8inx 6621 1 Results result NNS cord-010092-uftc8inx 6621 2 : : : cord-010092-uftc8inx 6622 1 The the DT cord-010092-uftc8inx 6622 2 activation activation NN cord-010092-uftc8inx 6622 3 / / SYM cord-010092-uftc8inx 6622 4 lesions lesion NNS cord-010092-uftc8inx 6622 5 on on IN cord-010092-uftc8inx 6622 6 total total JJ cord-010092-uftc8inx 6622 7 platelets platelet NNS cord-010092-uftc8inx 6622 8 and and CC cord-010092-uftc8inx 6622 9 small small JJ cord-010092-uftc8inx 6622 10 and and CC cord-010092-uftc8inx 6622 11 medium medium JJ cord-010092-uftc8inx 6622 12 - - HYPH cord-010092-uftc8inx 6622 13 sized sized JJ cord-010092-uftc8inx 6622 14 platelets platelet NNS cord-010092-uftc8inx 6622 15 platelet platelet NN cord-010092-uftc8inx 6622 16 population population NN cord-010092-uftc8inx 6622 17 was be VBD cord-010092-uftc8inx 6622 18 detected detect VBN cord-010092-uftc8inx 6622 19 on on IN cord-010092-uftc8inx 6622 20 storage storage NN cord-010092-uftc8inx 6622 21 day day NN cord-010092-uftc8inx 6622 22 3 3 CD cord-010092-uftc8inx 6622 23 , , , cord-010092-uftc8inx 6622 24 by by IN cord-010092-uftc8inx 6622 25 the the DT cord-010092-uftc8inx 6622 26 increased increase VBN cord-010092-uftc8inx 6622 27 expression expression NN cord-010092-uftc8inx 6622 28 of of IN cord-010092-uftc8inx 6622 29 CD36 CD36 NNP cord-010092-uftc8inx 6622 30 . . . cord-010092-uftc8inx 6623 1 The the DT cord-010092-uftc8inx 6623 2 percentage percentage NN cord-010092-uftc8inx 6623 3 of of IN cord-010092-uftc8inx 6623 4 CD36-positive cd36-positive JJ cord-010092-uftc8inx 6623 5 cells cell NNS cord-010092-uftc8inx 6623 6 among among IN cord-010092-uftc8inx 6623 7 the the DT cord-010092-uftc8inx 6623 8 population population NN cord-010092-uftc8inx 6623 9 of of IN cord-010092-uftc8inx 6623 10 large large JJ cord-010092-uftc8inx 6623 11 platelets platelet NNS cord-010092-uftc8inx 6623 12 did do VBD cord-010092-uftc8inx 6623 13 not not RB cord-010092-uftc8inx 6623 14 change change VB cord-010092-uftc8inx 6623 15 during during IN cord-010092-uftc8inx 6623 16 storage storage NN cord-010092-uftc8inx 6623 17 . . . cord-010092-uftc8inx 6624 1 On on IN cord-010092-uftc8inx 6624 2 the the DT cord-010092-uftc8inx 6624 3 day day NN cord-010092-uftc8inx 6624 4 3 3 CD cord-010092-uftc8inx 6624 5 , , , cord-010092-uftc8inx 6624 6 increased increase VBN cord-010092-uftc8inx 6624 7 expression expression NN cord-010092-uftc8inx 6624 8 of of IN cord-010092-uftc8inx 6624 9 CD42b CD42b NNP cord-010092-uftc8inx 6624 10 and and CC cord-010092-uftc8inx 6624 11 CD62p CD62p NNP cord-010092-uftc8inx 6624 12 was be VBD cord-010092-uftc8inx 6624 13 detected detect VBN cord-010092-uftc8inx 6624 14 , , , cord-010092-uftc8inx 6624 15 but but CC cord-010092-uftc8inx 6624 16 only only RB cord-010092-uftc8inx 6624 17 on on IN cord-010092-uftc8inx 6624 18 large large JJ cord-010092-uftc8inx 6624 19 platelets platelet NNS cord-010092-uftc8inx 6624 20 . . . cord-010092-uftc8inx 6625 1 Small small JJ cord-010092-uftc8inx 6625 2 and and CC cord-010092-uftc8inx 6625 3 medium medium JJ cord-010092-uftc8inx 6625 4 - - HYPH cord-010092-uftc8inx 6625 5 sized sized JJ cord-010092-uftc8inx 6625 6 platelets platelet NNS cord-010092-uftc8inx 6625 7 had have VBD cord-010092-uftc8inx 6625 8 increased increase VBN cord-010092-uftc8inx 6625 9 CD62p CD62p NNP cord-010092-uftc8inx 6625 10 expression expression NN cord-010092-uftc8inx 6625 11 only only RB cord-010092-uftc8inx 6625 12 on on IN cord-010092-uftc8inx 6625 13 day day NN cord-010092-uftc8inx 6625 14 5 5 CD cord-010092-uftc8inx 6625 15 . . . cord-010092-uftc8inx 6626 1 The the DT cord-010092-uftc8inx 6626 2 expression expression NN cord-010092-uftc8inx 6626 3 of of IN cord-010092-uftc8inx 6626 4 CD42a CD42a NNP cord-010092-uftc8inx 6626 5 on on IN cord-010092-uftc8inx 6626 6 total total JJ cord-010092-uftc8inx 6626 7 platelets platelet NNS cord-010092-uftc8inx 6626 8 increased increase VBD cord-010092-uftc8inx 6626 9 significantly significantly RB cord-010092-uftc8inx 6626 10 on on IN cord-010092-uftc8inx 6626 11 day day NN cord-010092-uftc8inx 6626 12 3 3 CD cord-010092-uftc8inx 6626 13 , , , cord-010092-uftc8inx 6626 14 and and CC cord-010092-uftc8inx 6626 15 stayed stay VBD cord-010092-uftc8inx 6626 16 unchanged unchanged JJ cord-010092-uftc8inx 6626 17 until until IN cord-010092-uftc8inx 6626 18 day day NN cord-010092-uftc8inx 6626 19 5 5 CD cord-010092-uftc8inx 6626 20 . . . cord-010092-uftc8inx 6627 1 The the DT cord-010092-uftc8inx 6627 2 same same JJ cord-010092-uftc8inx 6627 3 pattern pattern NN cord-010092-uftc8inx 6627 4 of of IN cord-010092-uftc8inx 6627 5 CD42a cd42a JJ cord-010092-uftc8inx 6627 6 expression expression NN cord-010092-uftc8inx 6627 7 was be VBD cord-010092-uftc8inx 6627 8 detected detect VBN cord-010092-uftc8inx 6627 9 for for IN cord-010092-uftc8inx 6627 10 small small JJ cord-010092-uftc8inx 6627 11 and and CC cord-010092-uftc8inx 6627 12 medium medium JJ cord-010092-uftc8inx 6627 13 - - HYPH cord-010092-uftc8inx 6627 14 sized sized JJ cord-010092-uftc8inx 6627 15 platelets platelet NNS cord-010092-uftc8inx 6627 16 , , , cord-010092-uftc8inx 6627 17 whereas whereas IN cord-010092-uftc8inx 6627 18 on on IN cord-010092-uftc8inx 6627 19 large large JJ cord-010092-uftc8inx 6627 20 platelets platelet NNS cord-010092-uftc8inx 6627 21 the the DT cord-010092-uftc8inx 6627 22 expression expression NN cord-010092-uftc8inx 6627 23 continued continue VBD cord-010092-uftc8inx 6627 24 to to TO cord-010092-uftc8inx 6627 25 increase increase VB cord-010092-uftc8inx 6627 26 until until IN cord-010092-uftc8inx 6627 27 the the DT cord-010092-uftc8inx 6627 28 end end NN cord-010092-uftc8inx 6627 29 of of IN cord-010092-uftc8inx 6627 30 storage storage NN cord-010092-uftc8inx 6627 31 . . . cord-010092-uftc8inx 6628 1 A a DT cord-010092-uftc8inx 6628 2 decreased decreased JJ cord-010092-uftc8inx 6628 3 percentage percentage NN cord-010092-uftc8inx 6628 4 of of IN cord-010092-uftc8inx 6628 5 CD41-positive cd41-positive JJ cord-010092-uftc8inx 6628 6 cells cell NNS cord-010092-uftc8inx 6628 7 was be VBD cord-010092-uftc8inx 6628 8 detected detect VBN cord-010092-uftc8inx 6628 9 among among IN cord-010092-uftc8inx 6628 10 the the DT cord-010092-uftc8inx 6628 11 total total JJ cord-010092-uftc8inx 6628 12 platelets platelet NNS cord-010092-uftc8inx 6628 13 and and CC cord-010092-uftc8inx 6628 14 populations population NNS cord-010092-uftc8inx 6628 15 of of IN cord-010092-uftc8inx 6628 16 medium medium NN cord-010092-uftc8inx 6628 17 - - HYPH cord-010092-uftc8inx 6628 18 sized sized JJ cord-010092-uftc8inx 6628 19 and and CC cord-010092-uftc8inx 6628 20 large large JJ cord-010092-uftc8inx 6628 21 platelets platelet NNS cord-010092-uftc8inx 6628 22 . . . cord-010092-uftc8inx 6629 1 The the DT cord-010092-uftc8inx 6629 2 storage storage NN cord-010092-uftc8inx 6629 3 induced induce VBD cord-010092-uftc8inx 6629 4 externalization externalization NN cord-010092-uftc8inx 6629 5 of of IN cord-010092-uftc8inx 6629 6 phosphatidylserine phosphatidylserine NN cord-010092-uftc8inx 6629 7 on on IN cord-010092-uftc8inx 6629 8 total total JJ cord-010092-uftc8inx 6629 9 platelets platelet NNS cord-010092-uftc8inx 6629 10 or or CC cord-010092-uftc8inx 6629 11 on on IN cord-010092-uftc8inx 6629 12 any any DT cord-010092-uftc8inx 6629 13 of of IN cord-010092-uftc8inx 6629 14 the the DT cord-010092-uftc8inx 6629 15 platelet platelet NN cord-010092-uftc8inx 6629 16 populations population NNS cord-010092-uftc8inx 6629 17 was be VBD cord-010092-uftc8inx 6629 18 not not RB cord-010092-uftc8inx 6629 19 detected detect VBN cord-010092-uftc8inx 6629 20 . . . cord-010092-uftc8inx 6630 1 The the DT cord-010092-uftc8inx 6630 2 levels level NNS cord-010092-uftc8inx 6630 3 of of IN cord-010092-uftc8inx 6630 4 TGF TGF NNP cord-010092-uftc8inx 6630 5 - - HYPH cord-010092-uftc8inx 6630 6 b b NNP cord-010092-uftc8inx 6630 7 and and CC cord-010092-uftc8inx 6630 8 P p NN cord-010092-uftc8inx 6630 9 - - HYPH cord-010092-uftc8inx 6630 10 selectin selectin NNP cord-010092-uftc8inx 6630 11 in in IN cord-010092-uftc8inx 6630 12 the the DT cord-010092-uftc8inx 6630 13 PC PC NNP cord-010092-uftc8inx 6630 14 - - HYPH cord-010092-uftc8inx 6630 15 BC BC NNP cord-010092-uftc8inx 6630 16 supernatants supernatant NNS cord-010092-uftc8inx 6630 17 were be VBD cord-010092-uftc8inx 6630 18 unchanged unchanged JJ cord-010092-uftc8inx 6630 19 during during IN cord-010092-uftc8inx 6630 20 the the DT cord-010092-uftc8inx 6630 21 5-day 5-day JJ cord-010092-uftc8inx 6630 22 storage storage NN cord-010092-uftc8inx 6630 23 period period NN cord-010092-uftc8inx 6630 24 . . . cord-010092-uftc8inx 6631 1 Increased increase VBN cord-010092-uftc8inx 6631 2 annexin annexin NN cord-010092-uftc8inx 6631 3 and and CC cord-010092-uftc8inx 6631 4 PF4 pf4 JJ cord-010092-uftc8inx 6631 5 concentrations concentration NNS cord-010092-uftc8inx 6631 6 were be VBD cord-010092-uftc8inx 6631 7 detected detect VBN cord-010092-uftc8inx 6631 8 on on IN cord-010092-uftc8inx 6631 9 day day NN cord-010092-uftc8inx 6631 10 5 5 CD cord-010092-uftc8inx 6631 11 . . . cord-010092-uftc8inx 6632 1 The the DT cord-010092-uftc8inx 6632 2 concentration concentration NN cord-010092-uftc8inx 6632 3 of of IN cord-010092-uftc8inx 6632 4 b b NNP cord-010092-uftc8inx 6632 5 - - HYPH cord-010092-uftc8inx 6632 6 TG TG NNP cord-010092-uftc8inx 6632 7 increased increase VBD cord-010092-uftc8inx 6632 8 on on IN cord-010092-uftc8inx 6632 9 day day NN cord-010092-uftc8inx 6632 10 3 3 CD cord-010092-uftc8inx 6632 11 of of IN cord-010092-uftc8inx 6632 12 storage storage NN cord-010092-uftc8inx 6632 13 , , , cord-010092-uftc8inx 6632 14 and and CC cord-010092-uftc8inx 6632 15 continued continue VBD cord-010092-uftc8inx 6632 16 to to TO cord-010092-uftc8inx 6632 17 rise rise VB cord-010092-uftc8inx 6632 18 until until IN cord-010092-uftc8inx 6632 19 the the DT cord-010092-uftc8inx 6632 20 end end NN cord-010092-uftc8inx 6632 21 of of IN cord-010092-uftc8inx 6632 22 storage storage NN cord-010092-uftc8inx 6632 23 . . . cord-010092-uftc8inx 6633 1 Summary Summary NNP cord-010092-uftc8inx 6633 2 / / SYM cord-010092-uftc8inx 6633 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 6633 4 : : : cord-010092-uftc8inx 6634 1 The the DT cord-010092-uftc8inx 6634 2 evaluation evaluation NN cord-010092-uftc8inx 6634 3 of of IN cord-010092-uftc8inx 6634 4 expression expression NN cord-010092-uftc8inx 6634 5 of of IN cord-010092-uftc8inx 6634 6 activation activation NN cord-010092-uftc8inx 6634 7 markers marker NNS cord-010092-uftc8inx 6634 8 on on IN cord-010092-uftc8inx 6634 9 different different JJ cord-010092-uftc8inx 6634 10 platelet platelet NN cord-010092-uftc8inx 6634 11 populations population NNS cord-010092-uftc8inx 6634 12 could could MD cord-010092-uftc8inx 6634 13 be be VB cord-010092-uftc8inx 6634 14 used use VBN cord-010092-uftc8inx 6634 15 as as IN cord-010092-uftc8inx 6634 16 an an DT cord-010092-uftc8inx 6634 17 additional additional JJ cord-010092-uftc8inx 6634 18 analysis analysis NN cord-010092-uftc8inx 6634 19 in in IN cord-010092-uftc8inx 6634 20 quality quality NN cord-010092-uftc8inx 6634 21 control control NN cord-010092-uftc8inx 6634 22 of of IN cord-010092-uftc8inx 6634 23 platelet platelet NN cord-010092-uftc8inx 6634 24 concentrates concentrate NNS cord-010092-uftc8inx 6634 25 , , , cord-010092-uftc8inx 6634 26 and and CC cord-010092-uftc8inx 6634 27 in in IN cord-010092-uftc8inx 6634 28 the the DT cord-010092-uftc8inx 6634 29 assessment assessment NN cord-010092-uftc8inx 6634 30 of of IN cord-010092-uftc8inx 6634 31 novel novel JJ cord-010092-uftc8inx 6634 32 approaches approach NNS cord-010092-uftc8inx 6634 33 to to IN cord-010092-uftc8inx 6634 34 platelet platelet NN cord-010092-uftc8inx 6634 35 concentrate concentrate VB cord-010092-uftc8inx 6634 36 manipulation manipulation NN cord-010092-uftc8inx 6634 37 i.e. i.e. FW cord-010092-uftc8inx 6634 38 for for IN cord-010092-uftc8inx 6634 39 testing test VBG cord-010092-uftc8inx 6634 40 new new JJ cord-010092-uftc8inx 6634 41 additive additive NN cord-010092-uftc8inx 6634 42 solutions solution NNS cord-010092-uftc8inx 6634 43 , , , cord-010092-uftc8inx 6634 44 cryoconservation cryoconservation NN cord-010092-uftc8inx 6634 45 protocols protocol NNS cord-010092-uftc8inx 6634 46 , , , cord-010092-uftc8inx 6634 47 and and CC cord-010092-uftc8inx 6634 48 cryoprotectants cryoprotectant NNS cord-010092-uftc8inx 6634 49 . . . cord-010092-uftc8inx 6635 1 Background background NN cord-010092-uftc8inx 6635 2 : : : cord-010092-uftc8inx 6636 1 The the DT cord-010092-uftc8inx 6636 2 primary primary JJ cord-010092-uftc8inx 6636 3 goal goal NN cord-010092-uftc8inx 6636 4 of of IN cord-010092-uftc8inx 6636 5 autologous autologous JJ cord-010092-uftc8inx 6636 6 blood blood NN cord-010092-uftc8inx 6636 7 transfusion transfusion NN cord-010092-uftc8inx 6636 8 is be VBZ cord-010092-uftc8inx 6636 9 to to TO cord-010092-uftc8inx 6636 10 reduce reduce VB cord-010092-uftc8inx 6636 11 the the DT cord-010092-uftc8inx 6636 12 risks risk NNS cord-010092-uftc8inx 6636 13 related relate VBN cord-010092-uftc8inx 6636 14 to to IN cord-010092-uftc8inx 6636 15 allogeneic allogeneic IN cord-010092-uftc8inx 6636 16 blood blood NN cord-010092-uftc8inx 6636 17 transfusion transfusion NN cord-010092-uftc8inx 6636 18 , , , cord-010092-uftc8inx 6636 19 including include VBG cord-010092-uftc8inx 6636 20 transfusion transfusion NN cord-010092-uftc8inx 6636 21 - - HYPH cord-010092-uftc8inx 6636 22 associated associate VBN cord-010092-uftc8inx 6636 23 graft graft NN cord-010092-uftc8inx 6636 24 - - HYPH cord-010092-uftc8inx 6636 25 versus versus IN cord-010092-uftc8inx 6636 26 - - HYPH cord-010092-uftc8inx 6636 27 host host NN cord-010092-uftc8inx 6636 28 disease disease NN cord-010092-uftc8inx 6636 29 ( ( -LRB- cord-010092-uftc8inx 6636 30 TA TA NNP cord-010092-uftc8inx 6636 31 - - HYPH cord-010092-uftc8inx 6636 32 GVHD GVHD NNP cord-010092-uftc8inx 6636 33 ) ) -RRB- cord-010092-uftc8inx 6636 34 . . . cord-010092-uftc8inx 6637 1 Although although IN cord-010092-uftc8inx 6637 2 downward downward JJ cord-010092-uftc8inx 6637 3 trends trend NNS cord-010092-uftc8inx 6637 4 in in IN cord-010092-uftc8inx 6637 5 rates rate NNS cord-010092-uftc8inx 6637 6 of of IN cord-010092-uftc8inx 6637 7 autologous autologous JJ cord-010092-uftc8inx 6637 8 blood blood NN cord-010092-uftc8inx 6637 9 transfusion transfusion NN cord-010092-uftc8inx 6637 10 have have VBP cord-010092-uftc8inx 6637 11 been be VBN cord-010092-uftc8inx 6637 12 reported report VBN cord-010092-uftc8inx 6637 13 in in IN cord-010092-uftc8inx 6637 14 Europe Europe NNP cord-010092-uftc8inx 6637 15 and and CC cord-010092-uftc8inx 6637 16 the the DT cord-010092-uftc8inx 6637 17 Americas Americas NNPS cord-010092-uftc8inx 6637 18 , , , cord-010092-uftc8inx 6637 19 it -PRON- PRP cord-010092-uftc8inx 6637 20 still still RB cord-010092-uftc8inx 6637 21 plays play VBZ cord-010092-uftc8inx 6637 22 a a DT cord-010092-uftc8inx 6637 23 role role NN cord-010092-uftc8inx 6637 24 in in IN cord-010092-uftc8inx 6637 25 eliminating eliminate VBG cord-010092-uftc8inx 6637 26 risks risk NNS cord-010092-uftc8inx 6637 27 related relate VBN cord-010092-uftc8inx 6637 28 to to IN cord-010092-uftc8inx 6637 29 allogeneic allogeneic IN cord-010092-uftc8inx 6637 30 blood blood NN cord-010092-uftc8inx 6637 31 transfusion transfusion NN cord-010092-uftc8inx 6637 32 in in IN cord-010092-uftc8inx 6637 33 Japan Japan NNP cord-010092-uftc8inx 6637 34 , , , cord-010092-uftc8inx 6637 35 especially especially RB cord-010092-uftc8inx 6637 36 TA TA NNP cord-010092-uftc8inx 6637 37 - - HYPH cord-010092-uftc8inx 6637 38 GVHD GVHD NNP cord-010092-uftc8inx 6637 39 . . . cord-010092-uftc8inx 6638 1 Since since IN cord-010092-uftc8inx 6638 2 February February NNP cord-010092-uftc8inx 6638 3 2009 2009 CD cord-010092-uftc8inx 6638 4 , , , cord-010092-uftc8inx 6638 5 the the DT cord-010092-uftc8inx 6638 6 transfusion transfusion NN cord-010092-uftc8inx 6638 7 service service NN cord-010092-uftc8inx 6638 8 in in IN cord-010092-uftc8inx 6638 9 our -PRON- PRP$ cord-010092-uftc8inx 6638 10 hospital hospital NN cord-010092-uftc8inx 6638 11 has have VBZ cord-010092-uftc8inx 6638 12 managed manage VBN cord-010092-uftc8inx 6638 13 3 3 CD cord-010092-uftc8inx 6638 14 autologous autologous JJ cord-010092-uftc8inx 6638 15 blood blood NN cord-010092-uftc8inx 6638 16 conservation conservation NN cord-010092-uftc8inx 6638 17 techniques technique NNS cord-010092-uftc8inx 6638 18 and and CC cord-010092-uftc8inx 6638 19 helped help VBD cord-010092-uftc8inx 6638 20 to to TO cord-010092-uftc8inx 6638 21 prevent prevent VB cord-010092-uftc8inx 6638 22 mistransfusion mistransfusion NN cord-010092-uftc8inx 6638 23 by by IN cord-010092-uftc8inx 6638 24 employing employ VBG cord-010092-uftc8inx 6638 25 a a DT cord-010092-uftc8inx 6638 26 bar bar NN cord-010092-uftc8inx 6638 27 code code NN cord-010092-uftc8inx 6638 28 - - HYPH cord-010092-uftc8inx 6638 29 based base VBN cord-010092-uftc8inx 6638 30 electronic electronic JJ cord-010092-uftc8inx 6638 31 identification identification NN cord-010092-uftc8inx 6638 32 system system NN cord-010092-uftc8inx 6638 33 . . . cord-010092-uftc8inx 6639 1 Aims aim VBZ cord-010092-uftc8inx 6639 2 : : : cord-010092-uftc8inx 6640 1 The the DT cord-010092-uftc8inx 6640 2 objective objective NN cord-010092-uftc8inx 6640 3 of of IN cord-010092-uftc8inx 6640 4 this this DT cord-010092-uftc8inx 6640 5 study study NN cord-010092-uftc8inx 6640 6 was be VBD cord-010092-uftc8inx 6640 7 to to TO cord-010092-uftc8inx 6640 8 determine determine VB cord-010092-uftc8inx 6640 9 the the DT cord-010092-uftc8inx 6640 10 use use NN cord-010092-uftc8inx 6640 11 of of IN cord-010092-uftc8inx 6640 12 3 3 CD cord-010092-uftc8inx 6640 13 types type NNS cord-010092-uftc8inx 6640 14 of of IN cord-010092-uftc8inx 6640 15 autologous autologous JJ cord-010092-uftc8inx 6640 16 blood blood NN cord-010092-uftc8inx 6640 17 components component NNS cord-010092-uftc8inx 6640 18 in in IN cord-010092-uftc8inx 6640 19 a a DT cord-010092-uftc8inx 6640 20 single single JJ cord-010092-uftc8inx 6640 21 institution institution NN cord-010092-uftc8inx 6640 22 over over IN cord-010092-uftc8inx 6640 23 an an DT cord-010092-uftc8inx 6640 24 approximately approximately RB cord-010092-uftc8inx 6640 25 9-year 9-year JJ cord-010092-uftc8inx 6640 26 period period NN cord-010092-uftc8inx 6640 27 . . . cord-010092-uftc8inx 6641 1 Methods method NNS cord-010092-uftc8inx 6641 2 : : : cord-010092-uftc8inx 6641 3 Between between IN cord-010092-uftc8inx 6641 4 February February NNP cord-010092-uftc8inx 6641 5 2009 2009 CD cord-010092-uftc8inx 6641 6 and and CC cord-010092-uftc8inx 6641 7 December December NNP cord-010092-uftc8inx 6641 8 2017 2017 CD cord-010092-uftc8inx 6641 9 , , , cord-010092-uftc8inx 6641 10 we -PRON- PRP cord-010092-uftc8inx 6641 11 retrospectively retrospectively RB cord-010092-uftc8inx 6641 12 analyzed analyze VBD cord-010092-uftc8inx 6641 13 autologous autologous JJ cord-010092-uftc8inx 6641 14 blood blood NN cord-010092-uftc8inx 6641 15 transfusion transfusion NN cord-010092-uftc8inx 6641 16 , , , cord-010092-uftc8inx 6641 17 including include VBG cord-010092-uftc8inx 6641 18 perioperative perioperative JJ cord-010092-uftc8inx 6641 19 autologous autologous JJ cord-010092-uftc8inx 6641 20 cell cell NN cord-010092-uftc8inx 6641 21 salvage salvage NN cord-010092-uftc8inx 6641 22 ( ( -LRB- cord-010092-uftc8inx 6641 23 PACS PACS NNP cord-010092-uftc8inx 6641 24 ) ) -RRB- cord-010092-uftc8inx 6641 25 , , , cord-010092-uftc8inx 6641 26 pre pre JJ cord-010092-uftc8inx 6641 27 - - JJ cord-010092-uftc8inx 6641 28 operative operative JJ cord-010092-uftc8inx 6641 29 autologous autologous JJ cord-010092-uftc8inx 6641 30 blood blood NN cord-010092-uftc8inx 6641 31 donation donation NN cord-010092-uftc8inx 6641 32 ( ( -LRB- cord-010092-uftc8inx 6641 33 PAD pad NN cord-010092-uftc8inx 6641 34 ) ) -RRB- cord-010092-uftc8inx 6641 35 , , , cord-010092-uftc8inx 6641 36 and and CC cord-010092-uftc8inx 6641 37 acute acute JJ cord-010092-uftc8inx 6641 38 normovolemic normovolemic JJ cord-010092-uftc8inx 6641 39 hemodilution hemodilution NNP cord-010092-uftc8inx 6641 40 ( ( -LRB- cord-010092-uftc8inx 6641 41 ANH ANH NNP cord-010092-uftc8inx 6641 42 ) ) -RRB- cord-010092-uftc8inx 6641 43 . . . cord-010092-uftc8inx 6642 1 We -PRON- PRP cord-010092-uftc8inx 6642 2 investigated investigate VBD cord-010092-uftc8inx 6642 3 the the DT cord-010092-uftc8inx 6642 4 use use NN cord-010092-uftc8inx 6642 5 of of IN cord-010092-uftc8inx 6642 6 autologous autologous JJ cord-010092-uftc8inx 6642 7 blood blood NN cord-010092-uftc8inx 6642 8 components component NNS cord-010092-uftc8inx 6642 9 and and CC cord-010092-uftc8inx 6642 10 the the DT cord-010092-uftc8inx 6642 11 rate rate NN cord-010092-uftc8inx 6642 12 of of IN cord-010092-uftc8inx 6642 13 complying comply VBG cord-010092-uftc8inx 6642 14 with with IN cord-010092-uftc8inx 6642 15 electronic electronic JJ cord-010092-uftc8inx 6642 16 pre pre JJ cord-010092-uftc8inx 6642 17 - - JJ cord-010092-uftc8inx 6642 18 transfusion transfusion JJ cord-010092-uftc8inx 6642 19 check check NN cord-010092-uftc8inx 6642 20 at at IN cord-010092-uftc8inx 6642 21 the the DT cord-010092-uftc8inx 6642 22 bedside bedside NN cord-010092-uftc8inx 6642 23 in in IN cord-010092-uftc8inx 6642 24 the the DT cord-010092-uftc8inx 6642 25 operating operate VBG cord-010092-uftc8inx 6642 26 rooms room NNS cord-010092-uftc8inx 6642 27 . . . cord-010092-uftc8inx 6643 1 We -PRON- PRP cord-010092-uftc8inx 6643 2 also also RB cord-010092-uftc8inx 6643 3 determined determine VBD cord-010092-uftc8inx 6643 4 the the DT cord-010092-uftc8inx 6643 5 adverse adverse JJ cord-010092-uftc8inx 6643 6 reactions reaction NNS cord-010092-uftc8inx 6643 7 to to IN cord-010092-uftc8inx 6643 8 autologous autologous JJ cord-010092-uftc8inx 6643 9 blood blood NN cord-010092-uftc8inx 6643 10 transfusion transfusion NN cord-010092-uftc8inx 6643 11 , , , cord-010092-uftc8inx 6643 12 which which WDT cord-010092-uftc8inx 6643 13 were be VBD cord-010092-uftc8inx 6643 14 categorized categorize VBN cord-010092-uftc8inx 6643 15 according accord VBG cord-010092-uftc8inx 6643 16 to to IN cord-010092-uftc8inx 6643 17 the the DT cord-010092-uftc8inx 6643 18 definitions definition NNS cord-010092-uftc8inx 6643 19 proposed propose VBN cord-010092-uftc8inx 6643 20 by by IN cord-010092-uftc8inx 6643 21 the the DT cord-010092-uftc8inx 6643 22 International International NNP cord-010092-uftc8inx 6643 23 Society Society NNP cord-010092-uftc8inx 6643 24 of of IN cord-010092-uftc8inx 6643 25 Blood Blood NNP cord-010092-uftc8inx 6643 26 Transfusion Transfusion NNP cord-010092-uftc8inx 6643 27 ( ( -LRB- cord-010092-uftc8inx 6643 28 ISBT ISBT NNP cord-010092-uftc8inx 6643 29 ) ) -RRB- cord-010092-uftc8inx 6643 30 Working Working NNP cord-010092-uftc8inx 6643 31 Party Party NNP cord-010092-uftc8inx 6643 32 on on IN cord-010092-uftc8inx 6643 33 Haemovigilance Haemovigilance NNP cord-010092-uftc8inx 6643 34 . . . cord-010092-uftc8inx 6644 1 Results result NNS cord-010092-uftc8inx 6644 2 : : : cord-010092-uftc8inx 6645 1 A a DT cord-010092-uftc8inx 6645 2 total total NN cord-010092-uftc8inx 6645 3 of of IN cord-010092-uftc8inx 6645 4 9,193 9,193 CD cord-010092-uftc8inx 6645 5 patients patient NNS cord-010092-uftc8inx 6645 6 ( ( -LRB- cord-010092-uftc8inx 6645 7 9 9 CD cord-010092-uftc8inx 6645 8 % % NN cord-010092-uftc8inx 6645 9 of of IN cord-010092-uftc8inx 6645 10 whom whom WP cord-010092-uftc8inx 6645 11 received receive VBD cord-010092-uftc8inx 6645 12 operations operation NNS cord-010092-uftc8inx 6645 13 ) ) -RRB- cord-010092-uftc8inx 6645 14 received receive VBD cord-010092-uftc8inx 6645 15 blood blood NN cord-010092-uftc8inx 6645 16 transfusion transfusion NN cord-010092-uftc8inx 6645 17 , , , cord-010092-uftc8inx 6645 18 of of IN cord-010092-uftc8inx 6645 19 which which WDT cord-010092-uftc8inx 6645 20 5,080 5,080 CD cord-010092-uftc8inx 6645 21 ( ( -LRB- cord-010092-uftc8inx 6645 22 55 55 CD cord-010092-uftc8inx 6645 23 % % NN cord-010092-uftc8inx 6645 24 ) ) -RRB- cord-010092-uftc8inx 6645 25 received receive VBD cord-010092-uftc8inx 6645 26 autologous autologous JJ cord-010092-uftc8inx 6645 27 blood blood NN cord-010092-uftc8inx 6645 28 transfusion transfusion NN cord-010092-uftc8inx 6645 29 alone alone RB cord-010092-uftc8inx 6645 30 , , , cord-010092-uftc8inx 6645 31 2,101 2,101 CD cord-010092-uftc8inx 6645 32 ( ( -LRB- cord-010092-uftc8inx 6645 33 23 23 CD cord-010092-uftc8inx 6645 34 % % NN cord-010092-uftc8inx 6645 35 ) ) -RRB- cord-010092-uftc8inx 6646 1 both both DT cord-010092-uftc8inx 6646 2 autologous autologous JJ cord-010092-uftc8inx 6646 3 and and CC cord-010092-uftc8inx 6646 4 allogeneic allogeneic IN cord-010092-uftc8inx 6646 5 blood blood NN cord-010092-uftc8inx 6646 6 transfusions transfusion NNS cord-010092-uftc8inx 6646 7 , , , cord-010092-uftc8inx 6646 8 and and CC cord-010092-uftc8inx 6646 9 2,012 2,012 CD cord-010092-uftc8inx 6646 10 ( ( -LRB- cord-010092-uftc8inx 6646 11 22 22 CD cord-010092-uftc8inx 6646 12 % % NN cord-010092-uftc8inx 6646 13 ) ) -RRB- cord-010092-uftc8inx 6647 1 allogeneic allogeneic IN cord-010092-uftc8inx 6647 2 blood blood NN cord-010092-uftc8inx 6647 3 transfusion transfusion NN cord-010092-uftc8inx 6647 4 alone alone RB cord-010092-uftc8inx 6647 5 . . . cord-010092-uftc8inx 6648 1 The the DT cord-010092-uftc8inx 6648 2 rate rate NN cord-010092-uftc8inx 6648 3 of of IN cord-010092-uftc8inx 6648 4 autologous autologous JJ cord-010092-uftc8inx 6648 5 blood blood NN cord-010092-uftc8inx 6648 6 transfusion transfusion NN cord-010092-uftc8inx 6648 7 among among IN cord-010092-uftc8inx 6648 8 patients patient NNS cord-010092-uftc8inx 6648 9 who who WP cord-010092-uftc8inx 6648 10 received receive VBD cord-010092-uftc8inx 6648 11 blood blood NN cord-010092-uftc8inx 6648 12 transfusion transfusion NN cord-010092-uftc8inx 6648 13 was be VBD cord-010092-uftc8inx 6648 14 78 78 CD cord-010092-uftc8inx 6648 15 % % NN cord-010092-uftc8inx 6648 16 . . . cord-010092-uftc8inx 6649 1 PACS PACS NNP cord-010092-uftc8inx 6649 2 units unit NNS cord-010092-uftc8inx 6649 3 were be VBD cord-010092-uftc8inx 6649 4 transfused transfuse VBN cord-010092-uftc8inx 6649 5 to to IN cord-010092-uftc8inx 6649 6 5,830 5,830 CD cord-010092-uftc8inx 6649 7 patients patient NNS cord-010092-uftc8inx 6649 8 ( ( -LRB- cord-010092-uftc8inx 6649 9 60 60 CD cord-010092-uftc8inx 6649 10 % % NN cord-010092-uftc8inx 6649 11 ) ) -RRB- cord-010092-uftc8inx 6649 12 , , , cord-010092-uftc8inx 6649 13 PAD pad NN cord-010092-uftc8inx 6649 14 units unit NNS cord-010092-uftc8inx 6649 15 to to IN cord-010092-uftc8inx 6649 16 2,845 2,845 CD cord-010092-uftc8inx 6649 17 patients patient NNS cord-010092-uftc8inx 6649 18 ( ( -LRB- cord-010092-uftc8inx 6649 19 30 30 CD cord-010092-uftc8inx 6649 20 % % NN cord-010092-uftc8inx 6649 21 ) ) -RRB- cord-010092-uftc8inx 6649 22 , , , cord-010092-uftc8inx 6649 23 and and CC cord-010092-uftc8inx 6649 24 ANH ANH NNP cord-010092-uftc8inx 6649 25 units unit NNS cord-010092-uftc8inx 6649 26 to to IN cord-010092-uftc8inx 6649 27 982 982 CD cord-010092-uftc8inx 6649 28 patients patient NNS cord-010092-uftc8inx 6649 29 ( ( -LRB- cord-010092-uftc8inx 6649 30 10 10 CD cord-010092-uftc8inx 6649 31 % % NN cord-010092-uftc8inx 6649 32 ) ) -RRB- cord-010092-uftc8inx 6649 33 , , , cord-010092-uftc8inx 6649 34 and and CC cord-010092-uftc8inx 6649 35 multiple multiple JJ cord-010092-uftc8inx 6649 36 blood blood NN cord-010092-uftc8inx 6649 37 conservation conservation NN cord-010092-uftc8inx 6649 38 techniques technique NNS cord-010092-uftc8inx 6649 39 were be VBD cord-010092-uftc8inx 6649 40 used use VBN cord-010092-uftc8inx 6649 41 for for IN cord-010092-uftc8inx 6649 42 one one CD cord-010092-uftc8inx 6649 43 patient patient NN cord-010092-uftc8inx 6649 44 . . . cord-010092-uftc8inx 6650 1 The the DT cord-010092-uftc8inx 6650 2 overall overall JJ cord-010092-uftc8inx 6650 3 compliance compliance NN cord-010092-uftc8inx 6650 4 rate rate NN cord-010092-uftc8inx 6650 5 with with IN cord-010092-uftc8inx 6650 6 electronic electronic JJ cord-010092-uftc8inx 6650 7 pre pre JJ cord-010092-uftc8inx 6650 8 - - JJ cord-010092-uftc8inx 6650 9 transfusion transfusion JJ cord-010092-uftc8inx 6650 10 check check NN cord-010092-uftc8inx 6650 11 at at IN cord-010092-uftc8inx 6650 12 the the DT cord-010092-uftc8inx 6650 13 bedside bedside NN cord-010092-uftc8inx 6650 14 in in IN cord-010092-uftc8inx 6650 15 autologous autologous JJ cord-010092-uftc8inx 6650 16 blood blood NN cord-010092-uftc8inx 6650 17 components component NNS cord-010092-uftc8inx 6650 18 was be VBD cord-010092-uftc8inx 6650 19 98.6 98.6 CD cord-010092-uftc8inx 6650 20 % % NN cord-010092-uftc8inx 6650 21 . . . cord-010092-uftc8inx 6651 1 Adverse adverse JJ cord-010092-uftc8inx 6651 2 reactions reaction NNS cord-010092-uftc8inx 6651 3 were be VBD cord-010092-uftc8inx 6651 4 observed observe VBN cord-010092-uftc8inx 6651 5 only only RB cord-010092-uftc8inx 6651 6 with with IN cord-010092-uftc8inx 6651 7 PAD pad NN cord-010092-uftc8inx 6651 8 transfusion transfusion NN cord-010092-uftc8inx 6651 9 and and CC cord-010092-uftc8inx 6651 10 not not RB cord-010092-uftc8inx 6651 11 PACS PACS NNP cord-010092-uftc8inx 6651 12 nor nor CC cord-010092-uftc8inx 6651 13 ANH ANH NNP cord-010092-uftc8inx 6651 14 . . . cord-010092-uftc8inx 6652 1 The the DT cord-010092-uftc8inx 6652 2 number number NN cord-010092-uftc8inx 6652 3 and and CC cord-010092-uftc8inx 6652 4 rate rate NN cord-010092-uftc8inx 6652 5 of of IN cord-010092-uftc8inx 6652 6 adverse adverse JJ cord-010092-uftc8inx 6652 7 reactions reaction NNS cord-010092-uftc8inx 6652 8 to to IN cord-010092-uftc8inx 6652 9 PAD pad NN cord-010092-uftc8inx 6652 10 transfusion transfusion NN cord-010092-uftc8inx 6652 11 were be VBD cord-010092-uftc8inx 6652 12 12 12 CD cord-010092-uftc8inx 6652 13 and and CC cord-010092-uftc8inx 6652 14 0.1 0.1 CD cord-010092-uftc8inx 6652 15 % % NN cord-010092-uftc8inx 6652 16 , , , cord-010092-uftc8inx 6652 17 respectively respectively RB cord-010092-uftc8inx 6652 18 , , , cord-010092-uftc8inx 6652 19 of of IN cord-010092-uftc8inx 6652 20 which which WDT cord-010092-uftc8inx 6652 21 the the DT cord-010092-uftc8inx 6652 22 most most RBS cord-010092-uftc8inx 6652 23 common common JJ cord-010092-uftc8inx 6652 24 was be VBD cord-010092-uftc8inx 6652 25 febrile febrile JJ cord-010092-uftc8inx 6652 26 non non JJ cord-010092-uftc8inx 6652 27 - - JJ cord-010092-uftc8inx 6652 28 hemolytic hemolytic JJ cord-010092-uftc8inx 6652 29 transfusion transfusion NN cord-010092-uftc8inx 6652 30 reaction reaction NN cord-010092-uftc8inx 6652 31 at at IN cord-010092-uftc8inx 6652 32 9 9 CD cord-010092-uftc8inx 6652 33 ( ( -LRB- cord-010092-uftc8inx 6652 34 75 75 CD cord-010092-uftc8inx 6652 35 % % NN cord-010092-uftc8inx 6652 36 ) ) -RRB- cord-010092-uftc8inx 6652 37 , , , cord-010092-uftc8inx 6652 38 followed follow VBN cord-010092-uftc8inx 6652 39 by by IN cord-010092-uftc8inx 6652 40 allergic allergic JJ cord-010092-uftc8inx 6652 41 reactions reaction NNS cord-010092-uftc8inx 6652 42 at at IN cord-010092-uftc8inx 6652 43 2 2 CD cord-010092-uftc8inx 6652 44 ( ( -LRB- cord-010092-uftc8inx 6652 45 17 17 CD cord-010092-uftc8inx 6652 46 % % NN cord-010092-uftc8inx 6652 47 ) ) -RRB- cord-010092-uftc8inx 6652 48 , , , cord-010092-uftc8inx 6652 49 and and CC cord-010092-uftc8inx 6652 50 hypotensive hypotensive JJ cord-010092-uftc8inx 6652 51 transfusion transfusion NN cord-010092-uftc8inx 6652 52 reaction reaction NN cord-010092-uftc8inx 6652 53 at at IN cord-010092-uftc8inx 6652 54 1 1 CD cord-010092-uftc8inx 6652 55 ( ( -LRB- cord-010092-uftc8inx 6652 56 8 8 CD cord-010092-uftc8inx 6652 57 % % NN cord-010092-uftc8inx 6652 58 ) ) -RRB- cord-010092-uftc8inx 6652 59 . . . cord-010092-uftc8inx 6653 1 The the DT cord-010092-uftc8inx 6653 2 severity severity NN cord-010092-uftc8inx 6653 3 of of IN cord-010092-uftc8inx 6653 4 adverse adverse JJ cord-010092-uftc8inx 6653 5 reactions reaction NNS cord-010092-uftc8inx 6653 6 to to IN cord-010092-uftc8inx 6653 7 PAD pad NN cord-010092-uftc8inx 6653 8 transfusion transfusion NN cord-010092-uftc8inx 6653 9 was be VBD cord-010092-uftc8inx 6653 10 Grade grade NN cord-010092-uftc8inx 6653 11 1 1 CD cord-010092-uftc8inx 6653 12 ( ( -LRB- cord-010092-uftc8inx 6653 13 non non JJ cord-010092-uftc8inx 6653 14 - - JJ cord-010092-uftc8inx 6653 15 severe severe JJ cord-010092-uftc8inx 6653 16 ) ) -RRB- cord-010092-uftc8inx 6653 17 in in IN cord-010092-uftc8inx 6653 18 all all DT cord-010092-uftc8inx 6653 19 cases case NNS cord-010092-uftc8inx 6653 20 , , , cord-010092-uftc8inx 6653 21 and and CC cord-010092-uftc8inx 6653 22 no no DT cord-010092-uftc8inx 6653 23 serious serious JJ cord-010092-uftc8inx 6653 24 adverse adverse JJ cord-010092-uftc8inx 6653 25 reactions reaction NNS cord-010092-uftc8inx 6653 26 were be VBD cord-010092-uftc8inx 6653 27 observed observe VBN cord-010092-uftc8inx 6653 28 . . . cord-010092-uftc8inx 6654 1 Among among IN cord-010092-uftc8inx 6654 2 PAD pad NN cord-010092-uftc8inx 6654 3 units unit NNS cord-010092-uftc8inx 6654 4 , , , cord-010092-uftc8inx 6654 5 the the DT cord-010092-uftc8inx 6654 6 rate rate NN cord-010092-uftc8inx 6654 7 of of IN cord-010092-uftc8inx 6654 8 adverse adverse JJ cord-010092-uftc8inx 6654 9 reactions reaction NNS cord-010092-uftc8inx 6654 10 to to IN cord-010092-uftc8inx 6654 11 whole whole JJ cord-010092-uftc8inx 6654 12 blood blood NN cord-010092-uftc8inx 6654 13 PAD pad NN cord-010092-uftc8inx 6654 14 units unit NNS cord-010092-uftc8inx 6654 15 was be VBD cord-010092-uftc8inx 6654 16 0.55 0.55 CD cord-010092-uftc8inx 6654 17 % % NN cord-010092-uftc8inx 6654 18 , , , cord-010092-uftc8inx 6654 19 that that DT cord-010092-uftc8inx 6654 20 to to IN cord-010092-uftc8inx 6654 21 frozen frozen JJ cord-010092-uftc8inx 6654 22 PAD pad NN cord-010092-uftc8inx 6654 23 units unit NNS cord-010092-uftc8inx 6654 24 was be VBD cord-010092-uftc8inx 6654 25 0.05 0.05 CD cord-010092-uftc8inx 6654 26 % % NN cord-010092-uftc8inx 6654 27 , , , cord-010092-uftc8inx 6654 28 and and CC cord-010092-uftc8inx 6654 29 that that IN cord-010092-uftc8inx 6654 30 to to IN cord-010092-uftc8inx 6654 31 autologous autologous JJ cord-010092-uftc8inx 6654 32 FFP FFP NNP cord-010092-uftc8inx 6654 33 units unit NNS cord-010092-uftc8inx 6654 34 was be VBD cord-010092-uftc8inx 6654 35 0.10 0.10 CD cord-010092-uftc8inx 6654 36 % % NN cord-010092-uftc8inx 6654 37 . . . cord-010092-uftc8inx 6655 1 Summary Summary NNP cord-010092-uftc8inx 6655 2 / / SYM cord-010092-uftc8inx 6655 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 6655 4 : : : cord-010092-uftc8inx 6656 1 Our -PRON- PRP$ cord-010092-uftc8inx 6656 2 observations observation NNS cord-010092-uftc8inx 6656 3 indicate indicate VBP cord-010092-uftc8inx 6656 4 that that IN cord-010092-uftc8inx 6656 5 the the DT cord-010092-uftc8inx 6656 6 rate rate NN cord-010092-uftc8inx 6656 7 of of IN cord-010092-uftc8inx 6656 8 autologous autologous JJ cord-010092-uftc8inx 6656 9 blood blood NN cord-010092-uftc8inx 6656 10 transfusion transfusion NN cord-010092-uftc8inx 6656 11 among among IN cord-010092-uftc8inx 6656 12 patients patient NNS cord-010092-uftc8inx 6656 13 who who WP cord-010092-uftc8inx 6656 14 received receive VBD cord-010092-uftc8inx 6656 15 blood blood NN cord-010092-uftc8inx 6656 16 transfusion transfusion NN cord-010092-uftc8inx 6656 17 was be VBD cord-010092-uftc8inx 6656 18 78 78 CD cord-010092-uftc8inx 6656 19 % % NN cord-010092-uftc8inx 6656 20 , , , cord-010092-uftc8inx 6656 21 when when WRB cord-010092-uftc8inx 6656 22 all all DT cord-010092-uftc8inx 6656 23 types type NNS cord-010092-uftc8inx 6656 24 of of IN cord-010092-uftc8inx 6656 25 autologous autologous JJ cord-010092-uftc8inx 6656 26 blood blood NN cord-010092-uftc8inx 6656 27 conservation conservation NN cord-010092-uftc8inx 6656 28 techniques technique NNS cord-010092-uftc8inx 6656 29 were be VBD cord-010092-uftc8inx 6656 30 included include VBN cord-010092-uftc8inx 6656 31 . . . cord-010092-uftc8inx 6657 1 To to TO cord-010092-uftc8inx 6657 2 accurately accurately RB cord-010092-uftc8inx 6657 3 determine determine VB cord-010092-uftc8inx 6657 4 the the DT cord-010092-uftc8inx 6657 5 rate rate NN cord-010092-uftc8inx 6657 6 of of IN cord-010092-uftc8inx 6657 7 autologous autologous JJ cord-010092-uftc8inx 6657 8 blood blood NN cord-010092-uftc8inx 6657 9 transfusion transfusion NN cord-010092-uftc8inx 6657 10 in in IN cord-010092-uftc8inx 6657 11 a a DT cord-010092-uftc8inx 6657 12 hospital hospital NN cord-010092-uftc8inx 6657 13 , , , cord-010092-uftc8inx 6657 14 it -PRON- PRP cord-010092-uftc8inx 6657 15 may may MD cord-010092-uftc8inx 6657 16 be be VB cord-010092-uftc8inx 6657 17 better well JJR cord-010092-uftc8inx 6657 18 for for IN cord-010092-uftc8inx 6657 19 the the DT cord-010092-uftc8inx 6657 20 transfusion transfusion NN cord-010092-uftc8inx 6657 21 service service NN cord-010092-uftc8inx 6657 22 to to TO cord-010092-uftc8inx 6657 23 manage manage VB cord-010092-uftc8inx 6657 24 all all DT cord-010092-uftc8inx 6657 25 types type NNS cord-010092-uftc8inx 6657 26 of of IN cord-010092-uftc8inx 6657 27 autologous autologous JJ cord-010092-uftc8inx 6657 28 blood blood NN cord-010092-uftc8inx 6657 29 conservation conservation NN cord-010092-uftc8inx 6657 30 techniques technique NNS cord-010092-uftc8inx 6657 31 . . . cord-010092-uftc8inx 6658 1 they -PRON- PRP cord-010092-uftc8inx 6658 2 are be VBP cord-010092-uftc8inx 6658 3 now now RB cord-010092-uftc8inx 6658 4 clinically clinically RB cord-010092-uftc8inx 6658 5 available available JJ cord-010092-uftc8inx 6658 6 as as IN cord-010092-uftc8inx 6658 7 a a DT cord-010092-uftc8inx 6658 8 blood blood NN cord-010092-uftc8inx 6658 9 product product NN cord-010092-uftc8inx 6658 10 . . . cord-010092-uftc8inx 6659 1 The the DT cord-010092-uftc8inx 6659 2 residual residual JJ cord-010092-uftc8inx 6659 3 plasma plasma NN cord-010092-uftc8inx 6659 4 level level NN cord-010092-uftc8inx 6659 5 of of IN cord-010092-uftc8inx 6659 6 this this DT cord-010092-uftc8inx 6659 7 product product NN cord-010092-uftc8inx 6659 8 , , , cord-010092-uftc8inx 6659 9 which which WDT cord-010092-uftc8inx 6659 10 is be VBZ cord-010092-uftc8inx 6659 11 prepared prepare VBN cord-010092-uftc8inx 6659 12 using use VBG cord-010092-uftc8inx 6659 13 the the DT cord-010092-uftc8inx 6659 14 automated automate VBN cord-010092-uftc8inx 6659 15 cell cell NN cord-010092-uftc8inx 6659 16 processor processor NN cord-010092-uftc8inx 6659 17 ACP215 ACP215 NNP cord-010092-uftc8inx 6659 18 ( ( -LRB- cord-010092-uftc8inx 6659 19 Haemonetics Haemonetics NNP cord-010092-uftc8inx 6659 20 Corp. Corp. NNP cord-010092-uftc8inx 6659 21 ) ) -RRB- cord-010092-uftc8inx 6659 22 , , , cord-010092-uftc8inx 6659 23 is be VBZ cord-010092-uftc8inx 6659 24 approximately approximately RB cord-010092-uftc8inx 6659 25 1 1 CD cord-010092-uftc8inx 6659 26 % % NN cord-010092-uftc8inx 6659 27 . . . cord-010092-uftc8inx 6660 1 Recently recently RB cord-010092-uftc8inx 6660 2 , , , cord-010092-uftc8inx 6660 3 a a DT cord-010092-uftc8inx 6660 4 retrospective retrospective JJ cord-010092-uftc8inx 6660 5 multicenter multicenter JJ cord-010092-uftc8inx 6660 6 study study NN cord-010092-uftc8inx 6660 7 was be VBD cord-010092-uftc8inx 6660 8 reported report VBN cord-010092-uftc8inx 6660 9 that that IN cord-010092-uftc8inx 6660 10 this this DT cord-010092-uftc8inx 6660 11 product product NN cord-010092-uftc8inx 6660 12 was be VBD cord-010092-uftc8inx 6660 13 effective effective JJ cord-010092-uftc8inx 6660 14 and and CC cord-010092-uftc8inx 6660 15 safety safety NN cord-010092-uftc8inx 6660 16 for for IN cord-010092-uftc8inx 6660 17 prevention prevention NN cord-010092-uftc8inx 6660 18 of of IN cord-010092-uftc8inx 6660 19 recurrent recurrent JJ cord-010092-uftc8inx 6660 20 or or CC cord-010092-uftc8inx 6660 21 severe severe JJ cord-010092-uftc8inx 6660 22 transfusion transfusion NN cord-010092-uftc8inx 6660 23 reactions reaction NNS cord-010092-uftc8inx 6660 24 . . . cord-010092-uftc8inx 6661 1 PLT PLT NNP cord-010092-uftc8inx 6661 2 products product NNS cord-010092-uftc8inx 6661 3 are be VBP cord-010092-uftc8inx 6661 4 generally generally RB cord-010092-uftc8inx 6661 5 stored store VBN cord-010092-uftc8inx 6661 6 with with IN cord-010092-uftc8inx 6661 7 continuous continuous JJ cord-010092-uftc8inx 6661 8 agitation agitation NN cord-010092-uftc8inx 6661 9 to to TO cord-010092-uftc8inx 6661 10 maintain maintain VB cord-010092-uftc8inx 6661 11 their -PRON- PRP$ cord-010092-uftc8inx 6661 12 quality quality NN cord-010092-uftc8inx 6661 13 . . . cord-010092-uftc8inx 6662 1 The the DT cord-010092-uftc8inx 6662 2 interrupted interrupted JJ cord-010092-uftc8inx 6662 3 agitation agitation NN cord-010092-uftc8inx 6662 4 of of IN cord-010092-uftc8inx 6662 5 PLT PLT NNP cord-010092-uftc8inx 6662 6 suspended suspend VBN cord-010092-uftc8inx 6662 7 in in IN cord-010092-uftc8inx 6662 8 additive additive NN cord-010092-uftc8inx 6662 9 solution solution NN cord-010092-uftc8inx 6662 10 ( ( -LRB- cord-010092-uftc8inx 6662 11 plasma plasma NN cord-010092-uftc8inx 6662 12 carryover carryover NN cord-010092-uftc8inx 6662 13 : : : cord-010092-uftc8inx 6662 14 3 3 CD cord-010092-uftc8inx 6662 15 - - SYM cord-010092-uftc8inx 6662 16 40 40 CD cord-010092-uftc8inx 6662 17 % % NN cord-010092-uftc8inx 6662 18 ) ) -RRB- cord-010092-uftc8inx 6662 19 for for IN cord-010092-uftc8inx 6662 20 up up IN cord-010092-uftc8inx 6662 21 to to TO cord-010092-uftc8inx 6662 22 24 24 CD cord-010092-uftc8inx 6662 23 h h NN cord-010092-uftc8inx 6662 24 was be VBD cord-010092-uftc8inx 6662 25 previously previously RB cord-010092-uftc8inx 6662 26 found find VBN cord-010092-uftc8inx 6662 27 to to TO cord-010092-uftc8inx 6662 28 have have VB cord-010092-uftc8inx 6662 29 only only RB cord-010092-uftc8inx 6662 30 a a DT cord-010092-uftc8inx 6662 31 slight slight JJ cord-010092-uftc8inx 6662 32 impact impact NN cord-010092-uftc8inx 6662 33 on on IN cord-010092-uftc8inx 6662 34 in in IN cord-010092-uftc8inx 6662 35 vitro vitro FW cord-010092-uftc8inx 6662 36 PLT PLT NNP cord-010092-uftc8inx 6662 37 properties property NNS cord-010092-uftc8inx 6662 38 . . . cord-010092-uftc8inx 6663 1 However however RB cord-010092-uftc8inx 6663 2 , , , cord-010092-uftc8inx 6663 3 in in IN cord-010092-uftc8inx 6663 4 some some DT cord-010092-uftc8inx 6663 5 small small JJ cord-010092-uftc8inx 6663 6 hospitals hospital NNS cord-010092-uftc8inx 6663 7 with with IN cord-010092-uftc8inx 6663 8 no no DT cord-010092-uftc8inx 6663 9 agitator agitator NN cord-010092-uftc8inx 6663 10 , , , cord-010092-uftc8inx 6663 11 if if IN cord-010092-uftc8inx 6663 12 the the DT cord-010092-uftc8inx 6663 13 initiation initiation NN cord-010092-uftc8inx 6663 14 of of IN cord-010092-uftc8inx 6663 15 transfusion transfusion NN cord-010092-uftc8inx 6663 16 is be VBZ cord-010092-uftc8inx 6663 17 delayed delay VBN cord-010092-uftc8inx 6663 18 by by IN cord-010092-uftc8inx 6663 19 an an DT cord-010092-uftc8inx 6663 20 emergent emergent JJ cord-010092-uftc8inx 6663 21 change change NN cord-010092-uftc8inx 6663 22 in in IN cord-010092-uftc8inx 6663 23 a a DT cord-010092-uftc8inx 6663 24 patient patient NN cord-010092-uftc8inx 6663 25 's 's POS cord-010092-uftc8inx 6663 26 condition condition NN cord-010092-uftc8inx 6663 27 , , , cord-010092-uftc8inx 6663 28 the the DT cord-010092-uftc8inx 6663 29 interruption interruption NN cord-010092-uftc8inx 6663 30 of of IN cord-010092-uftc8inx 6663 31 agitation agitation NN cord-010092-uftc8inx 6663 32 may may MD cord-010092-uftc8inx 6663 33 be be VB cord-010092-uftc8inx 6663 34 prolonged prolong VBN cord-010092-uftc8inx 6663 35 . . . cord-010092-uftc8inx 6664 1 Aims aim VBZ cord-010092-uftc8inx 6664 2 : : : cord-010092-uftc8inx 6665 1 The the DT cord-010092-uftc8inx 6665 2 aim aim NN cord-010092-uftc8inx 6665 3 of of IN cord-010092-uftc8inx 6665 4 this this DT cord-010092-uftc8inx 6665 5 study study NN cord-010092-uftc8inx 6665 6 was be VBD cord-010092-uftc8inx 6665 7 to to TO cord-010092-uftc8inx 6665 8 evaluate evaluate VB cord-010092-uftc8inx 6665 9 the the DT cord-010092-uftc8inx 6665 10 effects effect NNS cord-010092-uftc8inx 6665 11 the the DT cord-010092-uftc8inx 6665 12 interruption interruption NN cord-010092-uftc8inx 6665 13 of of IN cord-010092-uftc8inx 6665 14 agitation agitation NN cord-010092-uftc8inx 6665 15 for for IN cord-010092-uftc8inx 6665 16 48 48 CD cord-010092-uftc8inx 6665 17 h h NN cord-010092-uftc8inx 6665 18 ( ( -LRB- cord-010092-uftc8inx 6665 19 shelf shelf NN cord-010092-uftc8inx 6665 20 life life NN cord-010092-uftc8inx 6665 21 of of IN cord-010092-uftc8inx 6665 22 WPC WPC NNP cord-010092-uftc8inx 6665 23 in in IN cord-010092-uftc8inx 6665 24 Japan Japan NNP cord-010092-uftc8inx 6665 25 ) ) -RRB- cord-010092-uftc8inx 6665 26 on on IN cord-010092-uftc8inx 6665 27 the the DT cord-010092-uftc8inx 6665 28 in in FW cord-010092-uftc8inx 6665 29 vitro vitro FW cord-010092-uftc8inx 6665 30 qualities quality NNS cord-010092-uftc8inx 6665 31 of of IN cord-010092-uftc8inx 6665 32 PLT PLT NNP cord-010092-uftc8inx 6665 33 . . . cord-010092-uftc8inx 6666 1 Methods method NNS cord-010092-uftc8inx 6666 2 : : : cord-010092-uftc8inx 6666 3 Leukoreduced leukoreduced JJ cord-010092-uftc8inx 6666 4 apheresis apheresis NN cord-010092-uftc8inx 6666 5 platelet platelet NN cord-010092-uftc8inx 6666 6 concentrates concentrate VBZ cord-010092-uftc8inx 6666 7 in in IN cord-010092-uftc8inx 6666 8 100 100 CD cord-010092-uftc8inx 6666 9 % % NN cord-010092-uftc8inx 6666 10 plasma plasma NN cord-010092-uftc8inx 6666 11 were be VBD cord-010092-uftc8inx 6666 12 washed wash VBN cord-010092-uftc8inx 6666 13 on on IN cord-010092-uftc8inx 6666 14 day day NN cord-010092-uftc8inx 6666 15 one one CD cord-010092-uftc8inx 6666 16 after after IN cord-010092-uftc8inx 6666 17 blood blood NN cord-010092-uftc8inx 6666 18 collection collection NN cord-010092-uftc8inx 6666 19 using use VBG cord-010092-uftc8inx 6666 20 the the DT cord-010092-uftc8inx 6666 21 automated automate VBN cord-010092-uftc8inx 6666 22 closed close VBN cord-010092-uftc8inx 6666 23 - - HYPH cord-010092-uftc8inx 6666 24 system system NN cord-010092-uftc8inx 6666 25 cell cell NN cord-010092-uftc8inx 6666 26 processor processor NN cord-010092-uftc8inx 6667 1 ACP215 ACP215 NNP cord-010092-uftc8inx 6667 2 ( ( -LRB- cord-010092-uftc8inx 6667 3 N n NN cord-010092-uftc8inx 6667 4 = = SYM cord-010092-uftc8inx 6667 5 6 6 CD cord-010092-uftc8inx 6667 6 ) ) -RRB- cord-010092-uftc8inx 6667 7 . . . cord-010092-uftc8inx 6668 1 WPC WPC NNP cord-010092-uftc8inx 6668 2 , , , cord-010092-uftc8inx 6668 3 which which WDT cord-010092-uftc8inx 6668 4 were be VBD cord-010092-uftc8inx 6668 5 rested rest VBN cord-010092-uftc8inx 6668 6 1 1 CD cord-010092-uftc8inx 6668 7 h h NN cord-010092-uftc8inx 6668 8 after after IN cord-010092-uftc8inx 6668 9 preparing prepare VBG cord-010092-uftc8inx 6668 10 , , , cord-010092-uftc8inx 6668 11 were be VBD cord-010092-uftc8inx 6668 12 divided divide VBN cord-010092-uftc8inx 6668 13 equally equally RB cord-010092-uftc8inx 6668 14 into into IN cord-010092-uftc8inx 6668 15 control control NN cord-010092-uftc8inx 6668 16 and and CC cord-010092-uftc8inx 6668 17 test test NN cord-010092-uftc8inx 6668 18 units unit NNS cord-010092-uftc8inx 6668 19 using use VBG cord-010092-uftc8inx 6668 20 polyolefin polyolefin NN cord-010092-uftc8inx 6668 21 containers container NNS cord-010092-uftc8inx 6668 22 on on IN cord-010092-uftc8inx 6668 23 day day NN cord-010092-uftc8inx 6668 24 one one CD cord-010092-uftc8inx 6668 25 . . . cord-010092-uftc8inx 6669 1 Control control NN cord-010092-uftc8inx 6669 2 units unit NNS cord-010092-uftc8inx 6669 3 were be VBD cord-010092-uftc8inx 6669 4 agitated agitate VBN cord-010092-uftc8inx 6669 5 from from IN cord-010092-uftc8inx 6669 6 days day NNS cord-010092-uftc8inx 6669 7 one one CD cord-010092-uftc8inx 6669 8 to to IN cord-010092-uftc8inx 6669 9 seven seven CD cord-010092-uftc8inx 6669 10 . . . cord-010092-uftc8inx 6670 1 Test test NN cord-010092-uftc8inx 6670 2 units unit NNS cord-010092-uftc8inx 6670 3 were be VBD cord-010092-uftc8inx 6670 4 stored store VBN cord-010092-uftc8inx 6670 5 without without IN cord-010092-uftc8inx 6670 6 agitation agitation NN cord-010092-uftc8inx 6670 7 from from IN cord-010092-uftc8inx 6670 8 days day NNS cord-010092-uftc8inx 6670 9 one one CD cord-010092-uftc8inx 6670 10 to to IN cord-010092-uftc8inx 6670 11 three three CD cord-010092-uftc8inx 6670 12 , , , cord-010092-uftc8inx 6670 13 and and CC cord-010092-uftc8inx 6670 14 agitation agitation NN cord-010092-uftc8inx 6670 15 was be VBD cord-010092-uftc8inx 6670 16 subsequently subsequently RB cord-010092-uftc8inx 6670 17 performed perform VBN cord-010092-uftc8inx 6670 18 until until IN cord-010092-uftc8inx 6670 19 day day NN cord-010092-uftc8inx 6670 20 seven seven CD cord-010092-uftc8inx 6670 21 . . . cord-010092-uftc8inx 6671 1 Both both DT cord-010092-uftc8inx 6671 2 units unit NNS cord-010092-uftc8inx 6671 3 were be VBD cord-010092-uftc8inx 6671 4 stored store VBN cord-010092-uftc8inx 6671 5 at at IN cord-010092-uftc8inx 6671 6 20 20 CD cord-010092-uftc8inx 6671 7 - - SYM cord-010092-uftc8inx 6671 8 24 24 CD cord-010092-uftc8inx 6671 9 ° ° NN cord-010092-uftc8inx 6671 10 C c NN cord-010092-uftc8inx 6671 11 . . . cord-010092-uftc8inx 6672 1 In in IN cord-010092-uftc8inx 6672 2 vitro vitro JJ cord-010092-uftc8inx 6672 3 PLT PLT NNP cord-010092-uftc8inx 6672 4 quality quality NN cord-010092-uftc8inx 6672 5 was be VBD cord-010092-uftc8inx 6672 6 examined examine VBN cord-010092-uftc8inx 6672 7 on on IN cord-010092-uftc8inx 6672 8 days day NNS cord-010092-uftc8inx 6672 9 one one CD cord-010092-uftc8inx 6672 10 , , , cord-010092-uftc8inx 6672 11 three three CD cord-010092-uftc8inx 6672 12 , , , cord-010092-uftc8inx 6672 13 four four CD cord-010092-uftc8inx 6672 14 and and CC cord-010092-uftc8inx 6672 15 seven seven CD cord-010092-uftc8inx 6672 16 . . . cord-010092-uftc8inx 6673 1 Results result NNS cord-010092-uftc8inx 6673 2 : : : cord-010092-uftc8inx 6674 1 The the DT cord-010092-uftc8inx 6674 2 PLT PLT NNP cord-010092-uftc8inx 6674 3 concentration concentration NN cord-010092-uftc8inx 6674 4 of of IN cord-010092-uftc8inx 6674 5 prepared prepared JJ cord-010092-uftc8inx 6674 6 WPC WPC NNP cord-010092-uftc8inx 6674 7 was be VBD cord-010092-uftc8inx 6674 8 110.9 110.9 CD cord-010092-uftc8inx 6674 9 AE AE NNP cord-010092-uftc8inx 6674 10 1.9 1.9 CD cord-010092-uftc8inx 6674 11 ( ( -LRB- cord-010092-uftc8inx 6674 12 910 910 CD cord-010092-uftc8inx 6674 13 10 10 CD cord-010092-uftc8inx 6674 14 /L /L . cord-010092-uftc8inx 6674 15 ) ) -RRB- cord-010092-uftc8inx 6674 16 and and CC cord-010092-uftc8inx 6674 17 the the DT cord-010092-uftc8inx 6674 18 volumes volume NNS cord-010092-uftc8inx 6674 19 of of IN cord-010092-uftc8inx 6674 20 the the DT cord-010092-uftc8inx 6674 21 control control NN cord-010092-uftc8inx 6674 22 and and CC cord-010092-uftc8inx 6674 23 test test NN cord-010092-uftc8inx 6674 24 units unit NNS cord-010092-uftc8inx 6674 25 after after IN cord-010092-uftc8inx 6674 26 the the DT cord-010092-uftc8inx 6674 27 division division NN cord-010092-uftc8inx 6674 28 were be VBD cord-010092-uftc8inx 6674 29 120 120 CD cord-010092-uftc8inx 6674 30 AE AE NNP cord-010092-uftc8inx 6674 31 11 11 CD cord-010092-uftc8inx 6674 32 and and CC cord-010092-uftc8inx 6674 33 123 123 CD cord-010092-uftc8inx 6674 34 AE AE NNP cord-010092-uftc8inx 6674 35 12 12 CD cord-010092-uftc8inx 6674 36 ( ( -LRB- cord-010092-uftc8inx 6674 37 mL ml NN cord-010092-uftc8inx 6674 38 ) ) -RRB- cord-010092-uftc8inx 6674 39 . . . cord-010092-uftc8inx 6675 1 The the DT cord-010092-uftc8inx 6675 2 pH pH NNP cord-010092-uftc8inx 6675 3 values value NNS cord-010092-uftc8inx 6675 4 of of IN cord-010092-uftc8inx 6675 5 the the DT cord-010092-uftc8inx 6675 6 test test NN cord-010092-uftc8inx 6675 7 units unit NNS cord-010092-uftc8inx 6675 8 on on IN cord-010092-uftc8inx 6675 9 day day NN cord-010092-uftc8inx 6675 10 three three CD cord-010092-uftc8inx 6675 11 were be VBD cord-010092-uftc8inx 6675 12 lower low JJR cord-010092-uftc8inx 6675 13 than than IN cord-010092-uftc8inx 6675 14 those those DT cord-010092-uftc8inx 6675 15 of of IN cord-010092-uftc8inx 6675 16 the the DT cord-010092-uftc8inx 6675 17 control control NN cord-010092-uftc8inx 6675 18 units unit NNS cord-010092-uftc8inx 6675 19 ; ; : cord-010092-uftc8inx 6675 20 however however RB cord-010092-uftc8inx 6675 21 , , , cord-010092-uftc8inx 6675 22 the the DT cord-010092-uftc8inx 6675 23 pH ph NN cord-010092-uftc8inx 6675 24 of of IN cord-010092-uftc8inx 6675 25 both both DT cord-010092-uftc8inx 6675 26 units unit NNS cord-010092-uftc8inx 6675 27 were be VBD cord-010092-uftc8inx 6675 28 maintained maintain VBN cord-010092-uftc8inx 6675 29 at at IN cord-010092-uftc8inx 6675 30 higher high JJR cord-010092-uftc8inx 6675 31 than than IN cord-010092-uftc8inx 6675 32 6.85 6.85 CD cord-010092-uftc8inx 6675 33 during during IN cord-010092-uftc8inx 6675 34 the the DT cord-010092-uftc8inx 6675 35 seven seven CD cord-010092-uftc8inx 6675 36 - - HYPH cord-010092-uftc8inx 6675 37 day day NN cord-010092-uftc8inx 6675 38 storage storage NN cord-010092-uftc8inx 6675 39 period period NN cord-010092-uftc8inx 6675 40 . . . cord-010092-uftc8inx 6676 1 Swirling swirl VBG cord-010092-uftc8inx 6676 2 was be VBD cord-010092-uftc8inx 6676 3 well well RB cord-010092-uftc8inx 6676 4 maintained maintain VBN cord-010092-uftc8inx 6676 5 and and CC cord-010092-uftc8inx 6676 6 no no DT cord-010092-uftc8inx 6676 7 clumping clumping NN cord-010092-uftc8inx 6676 8 was be VBD cord-010092-uftc8inx 6676 9 visible visible JJ cord-010092-uftc8inx 6676 10 in in IN cord-010092-uftc8inx 6676 11 both both DT cord-010092-uftc8inx 6676 12 units unit NNS cord-010092-uftc8inx 6676 13 during during IN cord-010092-uftc8inx 6676 14 storage storage NN cord-010092-uftc8inx 6676 15 period period NN cord-010092-uftc8inx 6676 16 . . . cord-010092-uftc8inx 6677 1 No no DT cord-010092-uftc8inx 6677 2 significant significant JJ cord-010092-uftc8inx 6677 3 differences difference NNS cord-010092-uftc8inx 6677 4 were be VBD cord-010092-uftc8inx 6677 5 observed observe VBN cord-010092-uftc8inx 6677 6 in in IN cord-010092-uftc8inx 6677 7 PLTs PLTs NNP cord-010092-uftc8inx 6677 8 concentrates concentrate VBZ cord-010092-uftc8inx 6677 9 , , , cord-010092-uftc8inx 6677 10 MPV MPV NNP cord-010092-uftc8inx 6677 11 , , , cord-010092-uftc8inx 6677 12 HSR HSR NNP cord-010092-uftc8inx 6677 13 , , , cord-010092-uftc8inx 6677 14 Aggregation Aggregation NNP cord-010092-uftc8inx 6677 15 response response NN cord-010092-uftc8inx 6677 16 . . . cord-010092-uftc8inx 6678 1 The the DT cord-010092-uftc8inx 6678 2 pCO pco CD cord-010092-uftc8inx 6678 3 2 2 CD cord-010092-uftc8inx 6678 4 , , , cord-010092-uftc8inx 6678 5 pO po NN cord-010092-uftc8inx 6678 6 2 2 CD cord-010092-uftc8inx 6678 7 , , , cord-010092-uftc8inx 6678 8 bicarbonate bicarbonate NN cord-010092-uftc8inx 6678 9 , , , cord-010092-uftc8inx 6678 10 glucose glucose NN cord-010092-uftc8inx 6678 11 and and CC cord-010092-uftc8inx 6678 12 lactate lactate NN cord-010092-uftc8inx 6678 13 mean mean JJ cord-010092-uftc8inx 6678 14 values value NNS cord-010092-uftc8inx 6678 15 of of IN cord-010092-uftc8inx 6678 16 test test NN cord-010092-uftc8inx 6678 17 units unit NNS cord-010092-uftc8inx 6678 18 were be VBD cord-010092-uftc8inx 6678 19 slightly slightly RB cord-010092-uftc8inx 6678 20 lower low JJR cord-010092-uftc8inx 6678 21 or or CC cord-010092-uftc8inx 6678 22 higher high JJR cord-010092-uftc8inx 6678 23 than than IN cord-010092-uftc8inx 6678 24 those those DT cord-010092-uftc8inx 6678 25 of of IN cord-010092-uftc8inx 6678 26 the the DT cord-010092-uftc8inx 6678 27 control control NN cord-010092-uftc8inx 6678 28 units unit NNS cord-010092-uftc8inx 6678 29 on on IN cord-010092-uftc8inx 6678 30 days day NNS cord-010092-uftc8inx 6678 31 three three CD cord-010092-uftc8inx 6678 32 or or CC cord-010092-uftc8inx 6678 33 four four CD cord-010092-uftc8inx 6678 34 . . . cord-010092-uftc8inx 6679 1 The the DT cord-010092-uftc8inx 6679 2 levels level NNS cord-010092-uftc8inx 6679 3 of of IN cord-010092-uftc8inx 6679 4 CD62P cd62p NN cord-010092-uftc8inx 6679 5 expression expression NN cord-010092-uftc8inx 6679 6 were be VBD cord-010092-uftc8inx 6679 7 significantly significantly RB cord-010092-uftc8inx 6679 8 higher high JJR cord-010092-uftc8inx 6679 9 in in IN cord-010092-uftc8inx 6679 10 the the DT cord-010092-uftc8inx 6679 11 test test NN cord-010092-uftc8inx 6679 12 units unit NNS cord-010092-uftc8inx 6679 13 than than IN cord-010092-uftc8inx 6679 14 in in IN cord-010092-uftc8inx 6679 15 the the DT cord-010092-uftc8inx 6679 16 control control NN cord-010092-uftc8inx 6679 17 units unit NNS cord-010092-uftc8inx 6679 18 on on IN cord-010092-uftc8inx 6679 19 days day NNS cord-010092-uftc8inx 6679 20 three three CD cord-010092-uftc8inx 6679 21 ( ( -LRB- cord-010092-uftc8inx 6679 22 52.6 52.6 CD cord-010092-uftc8inx 6679 23 % % NN cord-010092-uftc8inx 6679 24 AE AE NNP cord-010092-uftc8inx 6679 25 6.0 6.0 CD cord-010092-uftc8inx 6679 26 vs vs IN cord-010092-uftc8inx 6679 27 40.9 40.9 CD cord-010092-uftc8inx 6679 28 AE AE NNP cord-010092-uftc8inx 6679 29 5.7 5.7 CD cord-010092-uftc8inx 6679 30 , , , cord-010092-uftc8inx 6679 31 P p NN cord-010092-uftc8inx 6679 32 < < XX cord-010092-uftc8inx 6679 33 0.01 0.01 CD cord-010092-uftc8inx 6679 34 ) ) -RRB- cord-010092-uftc8inx 6679 35 ; ; : cord-010092-uftc8inx 6679 36 however however RB cord-010092-uftc8inx 6679 37 , , , cord-010092-uftc8inx 6679 38 this this DT cord-010092-uftc8inx 6679 39 difference difference NN cord-010092-uftc8inx 6679 40 decreased decrease VBD cord-010092-uftc8inx 6679 41 in in IN cord-010092-uftc8inx 6679 42 a a DT cord-010092-uftc8inx 6679 43 time time NN cord-010092-uftc8inx 6679 44 - - HYPH cord-010092-uftc8inx 6679 45 dependent dependent JJ cord-010092-uftc8inx 6679 46 manner manner NN cord-010092-uftc8inx 6679 47 after after IN cord-010092-uftc8inx 6679 48 agitation agitation NN cord-010092-uftc8inx 6679 49 resumed resume VBD cord-010092-uftc8inx 6679 50 . . . cord-010092-uftc8inx 6680 1 The the DT cord-010092-uftc8inx 6680 2 levels level NNS cord-010092-uftc8inx 6680 3 of of IN cord-010092-uftc8inx 6680 4 CD42b CD42b NNP cord-010092-uftc8inx 6680 5 expression expression NN cord-010092-uftc8inx 6680 6 of of IN cord-010092-uftc8inx 6680 7 test test NN cord-010092-uftc8inx 6680 8 units unit NNS cord-010092-uftc8inx 6680 9 were be VBD cord-010092-uftc8inx 6680 10 relatively relatively RB cord-010092-uftc8inx 6680 11 lower low JJR cord-010092-uftc8inx 6680 12 than than IN cord-010092-uftc8inx 6680 13 those those DT cord-010092-uftc8inx 6680 14 of of IN cord-010092-uftc8inx 6680 15 the the DT cord-010092-uftc8inx 6680 16 control control NN cord-010092-uftc8inx 6680 17 units unit NNS cord-010092-uftc8inx 6680 18 until until IN cord-010092-uftc8inx 6680 19 day day NN cord-010092-uftc8inx 6680 20 seven seven CD cord-010092-uftc8inx 6680 21 , , , cord-010092-uftc8inx 6680 22 but but CC cord-010092-uftc8inx 6680 23 no no DT cord-010092-uftc8inx 6680 24 significant significant JJ cord-010092-uftc8inx 6680 25 difference difference NN cord-010092-uftc8inx 6680 26 between between IN cord-010092-uftc8inx 6680 27 the the DT cord-010092-uftc8inx 6680 28 two two CD cord-010092-uftc8inx 6680 29 units unit NNS cord-010092-uftc8inx 6680 30 . . . cord-010092-uftc8inx 6681 1 Background background NN cord-010092-uftc8inx 6681 2 : : : cord-010092-uftc8inx 6682 1 Monitoring monitor VBG cord-010092-uftc8inx 6682 2 residual residual JJ cord-010092-uftc8inx 6682 3 white white JJ cord-010092-uftc8inx 6682 4 blood blood NN cord-010092-uftc8inx 6682 5 cells cell NNS cord-010092-uftc8inx 6682 6 ( ( -LRB- cord-010092-uftc8inx 6682 7 rWBCs rwbcs NN cord-010092-uftc8inx 6682 8 ) ) -RRB- cord-010092-uftc8inx 6682 9 is be VBZ cord-010092-uftc8inx 6682 10 a a DT cord-010092-uftc8inx 6682 11 requirement requirement NN cord-010092-uftc8inx 6682 12 for for IN cord-010092-uftc8inx 6682 13 quality quality NN cord-010092-uftc8inx 6682 14 monitoring monitoring NN cord-010092-uftc8inx 6682 15 ( ( -LRB- cord-010092-uftc8inx 6682 16 QM QM NNP cord-010092-uftc8inx 6682 17 ) ) -RRB- cord-010092-uftc8inx 6683 1 the the DT cord-010092-uftc8inx 6683 2 production production NN cord-010092-uftc8inx 6683 3 of of IN cord-010092-uftc8inx 6683 4 leucocyte leucocyte NNP cord-010092-uftc8inx 6683 5 depleted deplete VBD cord-010092-uftc8inx 6683 6 blood blood NN cord-010092-uftc8inx 6683 7 components component NNS cord-010092-uftc8inx 6683 8 . . . cord-010092-uftc8inx 6684 1 Although although IN cord-010092-uftc8inx 6684 2 flow flow NN cord-010092-uftc8inx 6684 3 cytometry cytometry NN cord-010092-uftc8inx 6684 4 is be VBZ cord-010092-uftc8inx 6684 5 widely widely RB cord-010092-uftc8inx 6684 6 used use VBN cord-010092-uftc8inx 6684 7 for for IN cord-010092-uftc8inx 6684 8 monitoring monitor VBG cord-010092-uftc8inx 6684 9 rWBC rwbc JJ cord-010092-uftc8inx 6684 10 , , , cord-010092-uftc8inx 6684 11 there there EX cord-010092-uftc8inx 6684 12 are be VBP cord-010092-uftc8inx 6684 13 no no DT cord-010092-uftc8inx 6684 14 widely widely RB cord-010092-uftc8inx 6684 15 accepted accept VBN cord-010092-uftc8inx 6684 16 methods method NNS cord-010092-uftc8inx 6684 17 to to TO cord-010092-uftc8inx 6684 18 accurately accurately RB cord-010092-uftc8inx 6684 19 and and CC cord-010092-uftc8inx 6684 20 consistently consistently RB cord-010092-uftc8inx 6684 21 measure measure VB cord-010092-uftc8inx 6684 22 rRBCs rrbcs XX cord-010092-uftc8inx 6684 23 in in IN cord-010092-uftc8inx 6684 24 blood blood NN cord-010092-uftc8inx 6684 25 components component NNS cord-010092-uftc8inx 6684 26 . . . cord-010092-uftc8inx 6685 1 Sysmex Sysmex NNP cord-010092-uftc8inx 6685 2 have have VBP cord-010092-uftc8inx 6685 3 developed develop VBN cord-010092-uftc8inx 6685 4 a a DT cord-010092-uftc8inx 6685 5 novel novel NN cord-010092-uftc8inx 6685 6 algorithm algorithm NN cord-010092-uftc8inx 6685 7 , , , cord-010092-uftc8inx 6685 8 termed term VBD cord-010092-uftc8inx 6685 9 the the DT cord-010092-uftc8inx 6685 10 Blood Blood NNP cord-010092-uftc8inx 6685 11 Bank Bank NNP cord-010092-uftc8inx 6685 12 ( ( -LRB- cord-010092-uftc8inx 6685 13 BB BB NNP cord-010092-uftc8inx 6685 14 ) ) -RRB- cord-010092-uftc8inx 6685 15 mode mode NN cord-010092-uftc8inx 6685 16 for for IN cord-010092-uftc8inx 6685 17 their -PRON- PRP$ cord-010092-uftc8inx 6685 18 XN xn NN cord-010092-uftc8inx 6685 19 - - HYPH cord-010092-uftc8inx 6685 20 series series NN cord-010092-uftc8inx 6685 21 of of IN cord-010092-uftc8inx 6685 22 haematology haematology NNP cord-010092-uftc8inx 6685 23 analysers analyser NNS cord-010092-uftc8inx 6685 24 which which WDT cord-010092-uftc8inx 6685 25 is be VBZ cord-010092-uftc8inx 6685 26 specifically specifically RB cord-010092-uftc8inx 6685 27 designed design VBN cord-010092-uftc8inx 6685 28 to to TO cord-010092-uftc8inx 6685 29 quantitate quantitate VB cord-010092-uftc8inx 6685 30 the the DT cord-010092-uftc8inx 6685 31 levels level NNS cord-010092-uftc8inx 6685 32 of of IN cord-010092-uftc8inx 6685 33 rWBCs rwbcs CD cord-010092-uftc8inx 6685 34 and and CC cord-010092-uftc8inx 6685 35 rRBCs rrbc VBZ cord-010092-uftc8inx 6685 36 in in IN cord-010092-uftc8inx 6685 37 blood blood NN cord-010092-uftc8inx 6685 38 components component NNS cord-010092-uftc8inx 6685 39 . . . cord-010092-uftc8inx 6686 1 Aims aim VBZ cord-010092-uftc8inx 6686 2 : : : cord-010092-uftc8inx 6686 3 We -PRON- PRP cord-010092-uftc8inx 6686 4 have have VBP cord-010092-uftc8inx 6686 5 previously previously RB cord-010092-uftc8inx 6686 6 assessed assess VBN cord-010092-uftc8inx 6686 7 the the DT cord-010092-uftc8inx 6686 8 linearity linearity NN cord-010092-uftc8inx 6686 9 , , , cord-010092-uftc8inx 6686 10 accuracy accuracy NN cord-010092-uftc8inx 6686 11 and and CC cord-010092-uftc8inx 6686 12 reproducibility reproducibility NN cord-010092-uftc8inx 6686 13 of of IN cord-010092-uftc8inx 6686 14 the the DT cord-010092-uftc8inx 6686 15 BB bb NN cord-010092-uftc8inx 6686 16 mode mode NN cord-010092-uftc8inx 6686 17 on on IN cord-010092-uftc8inx 6686 18 spiked spiked JJ cord-010092-uftc8inx 6686 19 samples sample NNS cord-010092-uftc8inx 6686 20 in in IN cord-010092-uftc8inx 6686 21 an an DT cord-010092-uftc8inx 6686 22 R+D R+D NNP cord-010092-uftc8inx 6686 23 lab lab NN cord-010092-uftc8inx 6686 24 . . . cord-010092-uftc8inx 6687 1 We -PRON- PRP cord-010092-uftc8inx 6687 2 sought seek VBD cord-010092-uftc8inx 6687 3 to to TO cord-010092-uftc8inx 6687 4 further further RB cord-010092-uftc8inx 6687 5 assess assess VB cord-010092-uftc8inx 6687 6 the the DT cord-010092-uftc8inx 6687 7 performance performance NN cord-010092-uftc8inx 6687 8 of of IN cord-010092-uftc8inx 6687 9 the the DT cord-010092-uftc8inx 6687 10 BB bb NN cord-010092-uftc8inx 6687 11 software software NN cord-010092-uftc8inx 6687 12 in in IN cord-010092-uftc8inx 6687 13 a a DT cord-010092-uftc8inx 6687 14 routine routine JJ cord-010092-uftc8inx 6687 15 , , , cord-010092-uftc8inx 6687 16 high high JJ cord-010092-uftc8inx 6687 17 throughput throughput NN cord-010092-uftc8inx 6687 18 blood blood NN cord-010092-uftc8inx 6687 19 component component NN cord-010092-uftc8inx 6687 20 manufacturing manufacture VBG cord-010092-uftc8inx 6687 21 department department NN cord-010092-uftc8inx 6687 22 . . . cord-010092-uftc8inx 6688 1 Methods method NNS cord-010092-uftc8inx 6688 2 : : : cord-010092-uftc8inx 6689 1 Units unit NNS cord-010092-uftc8inx 6689 2 of of IN cord-010092-uftc8inx 6689 3 plasma plasma NN cord-010092-uftc8inx 6689 4 , , , cord-010092-uftc8inx 6689 5 platelets platelet NNS cord-010092-uftc8inx 6689 6 ( ( -LRB- cord-010092-uftc8inx 6689 7 PCs pc NNS cord-010092-uftc8inx 6689 8 ) ) -RRB- cord-010092-uftc8inx 6689 9 and and CC cord-010092-uftc8inx 6689 10 red red JJ cord-010092-uftc8inx 6689 11 cell cell NN cord-010092-uftc8inx 6689 12 concentrates concentrate VBZ cord-010092-uftc8inx 6689 13 ( ( -LRB- cord-010092-uftc8inx 6689 14 RCCs rccs NN cord-010092-uftc8inx 6689 15 ) ) -RRB- cord-010092-uftc8inx 6689 16 were be VBD cord-010092-uftc8inx 6689 17 produced produce VBN cord-010092-uftc8inx 6689 18 according accord VBG cord-010092-uftc8inx 6689 19 to to IN cord-010092-uftc8inx 6689 20 standard standard JJ cord-010092-uftc8inx 6689 21 UK UK NNP cord-010092-uftc8inx 6689 22 specifications specification NNS cord-010092-uftc8inx 6689 23 within within IN cord-010092-uftc8inx 6689 24 NHS NHS NNP cord-010092-uftc8inx 6689 25 Blood Blood NNP cord-010092-uftc8inx 6689 26 and and CC cord-010092-uftc8inx 6689 27 Transplant Transplant NNP cord-010092-uftc8inx 6689 28 ( ( -LRB- cord-010092-uftc8inx 6689 29 NHSBT NHSBT NNP cord-010092-uftc8inx 6689 30 ) ) -RRB- cord-010092-uftc8inx 6689 31 . . . cord-010092-uftc8inx 6690 1 QM QM NNP cord-010092-uftc8inx 6690 2 of of IN cord-010092-uftc8inx 6690 3 residual residual JJ cord-010092-uftc8inx 6690 4 cells cell NNS cord-010092-uftc8inx 6690 5 was be VBD cord-010092-uftc8inx 6690 6 tested test VBN cord-010092-uftc8inx 6690 7 using use VBG cord-010092-uftc8inx 6690 8 the the DT cord-010092-uftc8inx 6690 9 BB BB NNP cord-010092-uftc8inx 6690 10 mode mode NN cord-010092-uftc8inx 6690 11 whilst whilst IN cord-010092-uftc8inx 6690 12 rWBC rWBC NNP cord-010092-uftc8inx 6690 13 was be VBD cord-010092-uftc8inx 6690 14 additionally additionally RB cord-010092-uftc8inx 6690 15 analysed analyse VBN cord-010092-uftc8inx 6690 16 by by IN cord-010092-uftc8inx 6690 17 flow flow NN cord-010092-uftc8inx 6690 18 cytometry cytometry NN cord-010092-uftc8inx 6690 19 using use VBG cord-010092-uftc8inx 6690 20 BD BD NNP cord-010092-uftc8inx 6690 21 LeucoCOUNT LeucoCOUNT NNP cord-010092-uftc8inx 6690 22 kit kit NN cord-010092-uftc8inx 6690 23 . . . cord-010092-uftc8inx 6691 1 Results result NNS cord-010092-uftc8inx 6691 2 : : : cord-010092-uftc8inx 6691 3 During during IN cord-010092-uftc8inx 6691 4 a a DT cord-010092-uftc8inx 6691 5 2-month 2-month JJ cord-010092-uftc8inx 6691 6 field field NN cord-010092-uftc8inx 6691 7 trial trial NN cord-010092-uftc8inx 6691 8 over over IN cord-010092-uftc8inx 6691 9 10,000 10,000 CD cord-010092-uftc8inx 6691 10 data datum NNS cord-010092-uftc8inx 6691 11 points point NNS cord-010092-uftc8inx 6691 12 were be VBD cord-010092-uftc8inx 6691 13 collected collect VBN cord-010092-uftc8inx 6691 14 representing represent VBG cord-010092-uftc8inx 6691 15 all all DT cord-010092-uftc8inx 6691 16 types type NNS cord-010092-uftc8inx 6691 17 of of IN cord-010092-uftc8inx 6691 18 manufactured manufacture VBN cord-010092-uftc8inx 6691 19 component component NN cord-010092-uftc8inx 6691 20 . . . cord-010092-uftc8inx 6692 1 For for IN cord-010092-uftc8inx 6692 2 some some DT cord-010092-uftc8inx 6692 3 PCs pc NNS cord-010092-uftc8inx 6692 4 , , , cord-010092-uftc8inx 6692 5 BB bb NN cord-010092-uftc8inx 6692 6 mode mode NN cord-010092-uftc8inx 6692 7 results result NNS cord-010092-uftc8inx 6692 8 from from IN cord-010092-uftc8inx 6692 9 some some DT cord-010092-uftc8inx 6692 10 sample sample NN cord-010092-uftc8inx 6692 11 tubes tube NNS cord-010092-uftc8inx 6692 12 that that WDT cord-010092-uftc8inx 6692 13 did do VBD cord-010092-uftc8inx 6692 14 not not RB cord-010092-uftc8inx 6692 15 contain contain VB cord-010092-uftc8inx 6692 16 EDTA EDTA NNP cord-010092-uftc8inx 6692 17 gave give VBD cord-010092-uftc8inx 6692 18 very very RB cord-010092-uftc8inx 6692 19 high high JJ cord-010092-uftc8inx 6692 20 rWBC rwbc JJ cord-010092-uftc8inx 6692 21 values value NNS cord-010092-uftc8inx 6692 22 , , , cord-010092-uftc8inx 6692 23 indicating indicate VBG cord-010092-uftc8inx 6692 24 a a DT cord-010092-uftc8inx 6692 25 potential potential JJ cord-010092-uftc8inx 6692 26 large large JJ cord-010092-uftc8inx 6692 27 number number NN cord-010092-uftc8inx 6692 28 of of IN cord-010092-uftc8inx 6692 29 LD LD NNP cord-010092-uftc8inx 6692 30 failures failure NNS cord-010092-uftc8inx 6692 31 . . . cord-010092-uftc8inx 6693 1 The the DT cord-010092-uftc8inx 6693 2 results result NNS cord-010092-uftc8inx 6693 3 were be VBD cord-010092-uftc8inx 6693 4 significantly significantly RB cord-010092-uftc8inx 6693 5 different different JJ cord-010092-uftc8inx 6693 6 from from IN cord-010092-uftc8inx 6693 7 those those DT cord-010092-uftc8inx 6693 8 obtained obtain VBN cord-010092-uftc8inx 6693 9 from from IN cord-010092-uftc8inx 6693 10 PCs pc NNS cord-010092-uftc8inx 6693 11 using use VBG cord-010092-uftc8inx 6693 12 EDTA edta NN cord-010092-uftc8inx 6693 13 samples sample NNS cord-010092-uftc8inx 6693 14 ( ( -LRB- cord-010092-uftc8inx 6693 15 P p NN cord-010092-uftc8inx 6693 16 < < XX cord-010092-uftc8inx 6693 17 0.0001 0.0001 CD cord-010092-uftc8inx 6693 18 ) ) -RRB- cord-010092-uftc8inx 6693 19 which which WDT cord-010092-uftc8inx 6693 20 did do VBD cord-010092-uftc8inx 6693 21 not not RB cord-010092-uftc8inx 6693 22 show show VB cord-010092-uftc8inx 6693 23 the the DT cord-010092-uftc8inx 6693 24 same same JJ cord-010092-uftc8inx 6693 25 high high JJ cord-010092-uftc8inx 6693 26 values value NNS cord-010092-uftc8inx 6693 27 . . . cord-010092-uftc8inx 6694 1 For for IN cord-010092-uftc8inx 6694 2 RCCs rcc NNS cord-010092-uftc8inx 6694 3 or or CC cord-010092-uftc8inx 6694 4 plasma plasma NN cord-010092-uftc8inx 6694 5 , , , cord-010092-uftc8inx 6694 6 the the DT cord-010092-uftc8inx 6694 7 range range NN cord-010092-uftc8inx 6694 8 of of IN cord-010092-uftc8inx 6694 9 results result NNS cord-010092-uftc8inx 6694 10 from from IN cord-010092-uftc8inx 6694 11 plain plain JJ cord-010092-uftc8inx 6694 12 and and CC cord-010092-uftc8inx 6694 13 EDTA edta NN cord-010092-uftc8inx 6694 14 tubes tube NNS cord-010092-uftc8inx 6694 15 were be VBD cord-010092-uftc8inx 6694 16 not not RB cord-010092-uftc8inx 6694 17 significantly significantly RB cord-010092-uftc8inx 6694 18 different different JJ cord-010092-uftc8inx 6694 19 ( ( -LRB- cord-010092-uftc8inx 6694 20 P p NN cord-010092-uftc8inx 6694 21 ≥ ≥ CD cord-010092-uftc8inx 6694 22 0.3246 0.3246 CD cord-010092-uftc8inx 6694 23 ) ) -RRB- cord-010092-uftc8inx 6694 24 . . . cord-010092-uftc8inx 6695 1 The the DT cord-010092-uftc8inx 6695 2 analyses analysis NNS cord-010092-uftc8inx 6695 3 of of IN cord-010092-uftc8inx 6695 4 LD LD NNP cord-010092-uftc8inx 6695 5 platelet platelet NN cord-010092-uftc8inx 6695 6 and and CC cord-010092-uftc8inx 6695 7 plasma plasma NN cord-010092-uftc8inx 6695 8 concentrates concentrate NNS cord-010092-uftc8inx 6695 9 by by IN cord-010092-uftc8inx 6695 10 either either DT cord-010092-uftc8inx 6695 11 BB bb NN cord-010092-uftc8inx 6695 12 mode mode NN cord-010092-uftc8inx 6695 13 or or CC cord-010092-uftc8inx 6695 14 flow flow NN cord-010092-uftc8inx 6695 15 cytometry cytometry NN cord-010092-uftc8inx 6695 16 both both DT cord-010092-uftc8inx 6695 17 show show VBP cord-010092-uftc8inx 6695 18 more more JJR cord-010092-uftc8inx 6695 19 than than IN cord-010092-uftc8inx 6695 20 > > XX cord-010092-uftc8inx 6695 21 90 90 CD cord-010092-uftc8inx 6695 22 % % NN cord-010092-uftc8inx 6695 23 of of IN cord-010092-uftc8inx 6695 24 LD LD NNP cord-010092-uftc8inx 6695 25 components component NNS cord-010092-uftc8inx 6695 26 have have VBP cord-010092-uftc8inx 6695 27 less less JJR cord-010092-uftc8inx 6695 28 than than IN cord-010092-uftc8inx 6695 29 1 1 CD cord-010092-uftc8inx 6695 30 9 9 CD cord-010092-uftc8inx 6695 31 10 10 CD cord-010092-uftc8inx 6695 32 6 6 CD cord-010092-uftc8inx 6695 33 rWBC rWBC NNP cord-010092-uftc8inx 6695 34 / / SYM cord-010092-uftc8inx 6695 35 Unit unit NN cord-010092-uftc8inx 6695 36 . . . cord-010092-uftc8inx 6696 1 For for IN cord-010092-uftc8inx 6696 2 LD LD NNP cord-010092-uftc8inx 6696 3 failures failure NNS cord-010092-uftc8inx 6696 4 ( ( -LRB- cord-010092-uftc8inx 6696 5 n n NN cord-010092-uftc8inx 6696 6 = = SYM cord-010092-uftc8inx 6696 7 14 14 CD cord-010092-uftc8inx 6696 8 ) ) -RRB- cord-010092-uftc8inx 6696 9 there there EX cord-010092-uftc8inx 6696 10 was be VBD cord-010092-uftc8inx 6696 11 a a DT cord-010092-uftc8inx 6696 12 good good JJ cord-010092-uftc8inx 6696 13 correlation correlation NN cord-010092-uftc8inx 6696 14 ( ( -LRB- cord-010092-uftc8inx 6696 15 R r NN cord-010092-uftc8inx 6696 16 2 2 CD cord-010092-uftc8inx 6696 17 = = SYM cord-010092-uftc8inx 6696 18 0.9848 0.9848 CD cord-010092-uftc8inx 6696 19 ) ) -RRB- cord-010092-uftc8inx 6696 20 between between IN cord-010092-uftc8inx 6696 21 flow flow NN cord-010092-uftc8inx 6696 22 cytometry cytometry NN cord-010092-uftc8inx 6696 23 and and CC cord-010092-uftc8inx 6696 24 BB bb NN cord-010092-uftc8inx 6696 25 mode mode NN cord-010092-uftc8inx 6696 26 measurements measurement NNS cord-010092-uftc8inx 6696 27 . . . cord-010092-uftc8inx 6697 1 Spiking spiking NN cord-010092-uftc8inx 6697 2 studies study NNS cord-010092-uftc8inx 6697 3 suggested suggest VBD cord-010092-uftc8inx 6697 4 that that IN cord-010092-uftc8inx 6697 5 the the DT cord-010092-uftc8inx 6697 6 limits limit NNS cord-010092-uftc8inx 6697 7 of of IN cord-010092-uftc8inx 6697 8 detection detection NN cord-010092-uftc8inx 6697 9 and and CC cord-010092-uftc8inx 6697 10 quantitation quantitation NN cord-010092-uftc8inx 6697 11 of of IN cord-010092-uftc8inx 6697 12 rRBC rRBC NNP cord-010092-uftc8inx 6697 13 were be VBD cord-010092-uftc8inx 6697 14 around around RB cord-010092-uftc8inx 6697 15 6 6 CD cord-010092-uftc8inx 6697 16 and and CC cord-010092-uftc8inx 6697 17 8 8 CD cord-010092-uftc8inx 6697 18 rRBC rRBC NNP cord-010092-uftc8inx 6697 19 / / SYM cord-010092-uftc8inx 6697 20 lL lL NNP cord-010092-uftc8inx 6697 21 respectively respectively RB cord-010092-uftc8inx 6697 22 . . . cord-010092-uftc8inx 6698 1 Residual residual JJ cord-010092-uftc8inx 6698 2 red red JJ cord-010092-uftc8inx 6698 3 cell cell NN cord-010092-uftc8inx 6698 4 counts count NNS cord-010092-uftc8inx 6698 5 from from IN cord-010092-uftc8inx 6698 6 manufactured manufacture VBN cord-010092-uftc8inx 6698 7 components component NNS cord-010092-uftc8inx 6698 8 showed show VBD cord-010092-uftc8inx 6698 9 a a DT cord-010092-uftc8inx 6698 10 wide wide JJ cord-010092-uftc8inx 6698 11 variation variation NN cord-010092-uftc8inx 6698 12 in in IN cord-010092-uftc8inx 6698 13 their -PRON- PRP$ cord-010092-uftc8inx 6698 14 numbers number NNS cord-010092-uftc8inx 6698 15 between between IN cord-010092-uftc8inx 6698 16 units unit NNS cord-010092-uftc8inx 6698 17 . . . cord-010092-uftc8inx 6699 1 As as IN cord-010092-uftc8inx 6699 2 expected expect VBN cord-010092-uftc8inx 6699 3 platelet platelet NN cord-010092-uftc8inx 6699 4 production production NN cord-010092-uftc8inx 6699 5 methods method NNS cord-010092-uftc8inx 6699 6 also also RB cord-010092-uftc8inx 6699 7 showed show VBD cord-010092-uftc8inx 6699 8 a a DT cord-010092-uftc8inx 6699 9 significant significant JJ cord-010092-uftc8inx 6699 10 difference difference NN cord-010092-uftc8inx 6699 11 ( ( -LRB- cord-010092-uftc8inx 6699 12 P p NN cord-010092-uftc8inx 6699 13 < < XX cord-010092-uftc8inx 6699 14 0.0001 0.0001 CD cord-010092-uftc8inx 6699 15 ) ) -RRB- cord-010092-uftc8inx 6699 16 in in IN cord-010092-uftc8inx 6699 17 rRBC rrbc JJ cord-010092-uftc8inx 6699 18 contamination contamination NN cord-010092-uftc8inx 6699 19 , , , cord-010092-uftc8inx 6699 20 with with IN cord-010092-uftc8inx 6699 21 lower low JJR cord-010092-uftc8inx 6699 22 levels level NNS cord-010092-uftc8inx 6699 23 in in IN cord-010092-uftc8inx 6699 24 apheresis apheresis NN cord-010092-uftc8inx 6699 25 platelets platelet NNS cord-010092-uftc8inx 6699 26 ( ( -LRB- cord-010092-uftc8inx 6699 27 median median NN cord-010092-uftc8inx 6699 28 = = SYM cord-010092-uftc8inx 6699 29 15 15 CD cord-010092-uftc8inx 6700 1 RBC RBC NNP cord-010092-uftc8inx 6700 2 / / SYM cord-010092-uftc8inx 6700 3 lL lL NNP cord-010092-uftc8inx 6700 4 , , , cord-010092-uftc8inx 6700 5 n n NN cord-010092-uftc8inx 6700 6 = = SYM cord-010092-uftc8inx 6700 7 1820 1820 CD cord-010092-uftc8inx 6700 8 ) ) -RRB- cord-010092-uftc8inx 6701 1 compared compare VBN cord-010092-uftc8inx 6701 2 to to IN cord-010092-uftc8inx 6701 3 those those DT cord-010092-uftc8inx 6701 4 produced produce VBN cord-010092-uftc8inx 6701 5 from from IN cord-010092-uftc8inx 6701 6 buffy buffy NNP cord-010092-uftc8inx 6701 7 coats coat NNS cord-010092-uftc8inx 6701 8 ( ( -LRB- cord-010092-uftc8inx 6701 9 median median NN cord-010092-uftc8inx 6701 10 = = SYM cord-010092-uftc8inx 6701 11 783 783 CD cord-010092-uftc8inx 6701 12 RBC RBC NNP cord-010092-uftc8inx 6701 13 / / SYM cord-010092-uftc8inx 6701 14 lL lL NNP cord-010092-uftc8inx 6701 15 , , , cord-010092-uftc8inx 6701 16 n n NN cord-010092-uftc8inx 6701 17 = = SYM cord-010092-uftc8inx 6701 18 77 77 CD cord-010092-uftc8inx 6701 19 ) ) -RRB- cord-010092-uftc8inx 6702 1 In in IN cord-010092-uftc8inx 6702 2 our -PRON- PRP$ cord-010092-uftc8inx 6702 3 hands hand NNS cord-010092-uftc8inx 6702 4 , , , cord-010092-uftc8inx 6702 5 although although IN cord-010092-uftc8inx 6702 6 the the DT cord-010092-uftc8inx 6702 7 time time NN cord-010092-uftc8inx 6702 8 taken take VBN cord-010092-uftc8inx 6702 9 to to TO cord-010092-uftc8inx 6702 10 analyse analyse VB cord-010092-uftc8inx 6702 11 samples sample NNS cord-010092-uftc8inx 6702 12 is be VBZ cord-010092-uftc8inx 6702 13 similar similar JJ cord-010092-uftc8inx 6702 14 for for IN cord-010092-uftc8inx 6702 15 flow flow NN cord-010092-uftc8inx 6702 16 cytometry cytometry NN cord-010092-uftc8inx 6702 17 and and CC cord-010092-uftc8inx 6702 18 BB bb NN cord-010092-uftc8inx 6702 19 mode mode NN cord-010092-uftc8inx 6702 20 , , , cord-010092-uftc8inx 6702 21 considerable considerable JJ cord-010092-uftc8inx 6702 22 time time NN cord-010092-uftc8inx 6702 23 can can MD cord-010092-uftc8inx 6702 24 be be VB cord-010092-uftc8inx 6702 25 saved save VBN cord-010092-uftc8inx 6702 26 on on IN cord-010092-uftc8inx 6702 27 manual manual JJ cord-010092-uftc8inx 6702 28 handling handling NN cord-010092-uftc8inx 6702 29 and and CC cord-010092-uftc8inx 6702 30 the the DT cord-010092-uftc8inx 6702 31 processing processing NN cord-010092-uftc8inx 6702 32 of of IN cord-010092-uftc8inx 6702 33 samples sample NNS cord-010092-uftc8inx 6702 34 for for IN cord-010092-uftc8inx 6702 35 flow flow NN cord-010092-uftc8inx 6702 36 cytometry cytometry NN cord-010092-uftc8inx 6702 37 ( ( -LRB- cord-010092-uftc8inx 6702 38 approximately approximately RB cord-010092-uftc8inx 6702 39 2 2 CD cord-010092-uftc8inx 6702 40 - - SYM cord-010092-uftc8inx 6702 41 3 3 CD cord-010092-uftc8inx 6702 42 h h NN cord-010092-uftc8inx 6702 43 for for IN cord-010092-uftc8inx 6702 44 60 60 CD cord-010092-uftc8inx 6702 45 - - SYM cord-010092-uftc8inx 6702 46 90 90 CD cord-010092-uftc8inx 6702 47 samples sample NNS cord-010092-uftc8inx 6702 48 ) ) -RRB- cord-010092-uftc8inx 6702 49 . . . cord-010092-uftc8inx 6703 1 Summary Summary NNP cord-010092-uftc8inx 6703 2 / / SYM cord-010092-uftc8inx 6703 3 Conclusions conclusion NNS cord-010092-uftc8inx 6703 4 : : : cord-010092-uftc8inx 6703 5 We -PRON- PRP cord-010092-uftc8inx 6703 6 have have VBP cord-010092-uftc8inx 6703 7 been be VBN cord-010092-uftc8inx 6703 8 able able JJ cord-010092-uftc8inx 6703 9 to to TO cord-010092-uftc8inx 6703 10 embed embed VB cord-010092-uftc8inx 6703 11 the the DT cord-010092-uftc8inx 6703 12 Sysmex Sysmex NNP cord-010092-uftc8inx 6703 13 BB BB NNP cord-010092-uftc8inx 6703 14 mode mode NN cord-010092-uftc8inx 6703 15 into into IN cord-010092-uftc8inx 6703 16 a a DT cord-010092-uftc8inx 6703 17 routine routine JJ cord-010092-uftc8inx 6703 18 production production NN cord-010092-uftc8inx 6703 19 environment environment NN cord-010092-uftc8inx 6703 20 and and CC cord-010092-uftc8inx 6703 21 confirm confirm VB cord-010092-uftc8inx 6703 22 that that IN cord-010092-uftc8inx 6703 23 its -PRON- PRP$ cord-010092-uftc8inx 6703 24 performance performance NN cord-010092-uftc8inx 6703 25 in in IN cord-010092-uftc8inx 6703 26 spiked spiked JJ cord-010092-uftc8inx 6703 27 samples sample NNS cord-010092-uftc8inx 6703 28 is be VBZ cord-010092-uftc8inx 6703 29 mirrored mirror VBN cord-010092-uftc8inx 6703 30 in in IN cord-010092-uftc8inx 6703 31 routine routine JJ cord-010092-uftc8inx 6703 32 use use NN cord-010092-uftc8inx 6703 33 . . . cord-010092-uftc8inx 6704 1 For for IN cord-010092-uftc8inx 6704 2 platelets platelet NNS cord-010092-uftc8inx 6704 3 , , , cord-010092-uftc8inx 6704 4 sample sample NN cord-010092-uftc8inx 6704 5 collection collection NN cord-010092-uftc8inx 6704 6 in in IN cord-010092-uftc8inx 6704 7 EDTA EDTA NNP cord-010092-uftc8inx 6704 8 is be VBZ cord-010092-uftc8inx 6704 9 essential essential JJ cord-010092-uftc8inx 6704 10 . . . cord-010092-uftc8inx 6705 1 The the DT cord-010092-uftc8inx 6705 2 BB bb NN cord-010092-uftc8inx 6705 3 mode mode NN cord-010092-uftc8inx 6705 4 offers offer VBZ cord-010092-uftc8inx 6705 5 an an DT cord-010092-uftc8inx 6705 6 opportunity opportunity NN cord-010092-uftc8inx 6705 7 to to TO cord-010092-uftc8inx 6705 8 reduce reduce VB cord-010092-uftc8inx 6705 9 operator operator NN cord-010092-uftc8inx 6705 10 time time NN cord-010092-uftc8inx 6705 11 compared compare VBN cord-010092-uftc8inx 6705 12 to to TO cord-010092-uftc8inx 6705 13 flow flow VB cord-010092-uftc8inx 6705 14 cytometry cytometry NN cord-010092-uftc8inx 6705 15 whilst whilst IN cord-010092-uftc8inx 6705 16 gaining gain VBG cord-010092-uftc8inx 6705 17 additional additional JJ cord-010092-uftc8inx 6705 18 information information NN cord-010092-uftc8inx 6705 19 on on IN cord-010092-uftc8inx 6705 20 rRBC rRBC NNP cord-010092-uftc8inx 6705 21 . . . cord-010092-uftc8inx 6706 1 Abstract Abstract NNP cord-010092-uftc8inx 6706 2 withdrawn withdraw VBN cord-010092-uftc8inx 6706 3 . . . cord-010092-uftc8inx 6707 1 Results result NNS cord-010092-uftc8inx 6707 2 : : : cord-010092-uftc8inx 6708 1 In in IN cord-010092-uftc8inx 6708 2 our -PRON- PRP$ cord-010092-uftc8inx 6708 3 experiment experiment NN cord-010092-uftc8inx 6708 4 , , , cord-010092-uftc8inx 6708 5 the the DT cord-010092-uftc8inx 6708 6 typical typical JJ cord-010092-uftc8inx 6708 7 size size NN cord-010092-uftc8inx 6708 8 of of IN cord-010092-uftc8inx 6708 9 a a DT cord-010092-uftc8inx 6708 10 spectrin spectrin NNP cord-010092-uftc8inx 6708 11 matrix matrix NN cord-010092-uftc8inx 6708 12 section section NN cord-010092-uftc8inx 6708 13 ( ( -LRB- cord-010092-uftc8inx 6708 14 L L NNP cord-010092-uftc8inx 6708 15 ) ) -RRB- cord-010092-uftc8inx 6708 16 was be VBD cord-010092-uftc8inx 6708 17 60 60 CD cord-010092-uftc8inx 6708 18 to to IN cord-010092-uftc8inx 6708 19 220 220 CD cord-010092-uftc8inx 6708 20 nm nm NN cord-010092-uftc8inx 6708 21 ( ( -LRB- cord-010092-uftc8inx 6708 22 without without IN cord-010092-uftc8inx 6708 23 oxidation oxidation NN cord-010092-uftc8inx 6708 24 ) ) -RRB- cord-010092-uftc8inx 6708 25 . . . cord-010092-uftc8inx 6709 1 The the DT cord-010092-uftc8inx 6709 2 heights height NNS cord-010092-uftc8inx 6709 3 ( ( -LRB- cord-010092-uftc8inx 6709 4 h h NN cord-010092-uftc8inx 6709 5 ) ) -RRB- cord-010092-uftc8inx 6709 6 of of IN cord-010092-uftc8inx 6709 7 dips dip NNS cord-010092-uftc8inx 6709 8 were be VBD cord-010092-uftc8inx 6709 9 4 4 CD cord-010092-uftc8inx 6709 10 to to TO cord-010092-uftc8inx 6709 11 10 10 CD cord-010092-uftc8inx 6709 12 nm nm NN cord-010092-uftc8inx 6709 13 . . . cord-010092-uftc8inx 6710 1 Due due IN cord-010092-uftc8inx 6710 2 to to IN cord-010092-uftc8inx 6710 3 oxidation oxidation NN cord-010092-uftc8inx 6710 4 , , , cord-010092-uftc8inx 6710 5 the the DT cord-010092-uftc8inx 6710 6 junctional junctional JJ cord-010092-uftc8inx 6710 7 complexes complex NNS cord-010092-uftc8inx 6710 8 between between IN cord-010092-uftc8inx 6710 9 spectrin spectrin NNS cord-010092-uftc8inx 6710 10 and and CC cord-010092-uftc8inx 6710 11 membrane membrane NN cord-010092-uftc8inx 6710 12 proteins protein NNS cord-010092-uftc8inx 6710 13 can can MD cord-010092-uftc8inx 6710 14 rupture rupture VB cord-010092-uftc8inx 6710 15 . . . cord-010092-uftc8inx 6711 1 Only only RB cord-010092-uftc8inx 6711 2 10 10 CD cord-010092-uftc8inx 6711 3 % % NN cord-010092-uftc8inx 6711 4 to to TO cord-010092-uftc8inx 6711 5 15 15 CD cord-010092-uftc8inx 6711 6 % % NN cord-010092-uftc8inx 6711 7 of of IN cord-010092-uftc8inx 6711 8 the the DT cord-010092-uftc8inx 6711 9 spectrin spectrin NNP cord-010092-uftc8inx 6711 10 surface surface NN cord-010092-uftc8inx 6711 11 has have VBZ cord-010092-uftc8inx 6711 12 the the DT cord-010092-uftc8inx 6711 13 same same JJ cord-010092-uftc8inx 6711 14 structure structure NN cord-010092-uftc8inx 6711 15 as as IN cord-010092-uftc8inx 6711 16 in in IN cord-010092-uftc8inx 6711 17 the the DT cord-010092-uftc8inx 6711 18 control control NN cord-010092-uftc8inx 6711 19 group group NN cord-010092-uftc8inx 6711 20 . . . cord-010092-uftc8inx 6712 1 The the DT cord-010092-uftc8inx 6712 2 values value NNS cord-010092-uftc8inx 6712 3 of of IN cord-010092-uftc8inx 6712 4 L L NNP cord-010092-uftc8inx 6712 5 and and CC cord-010092-uftc8inx 6712 6 h h NN cord-010092-uftc8inx 6712 7 vary vary VBP cord-010092-uftc8inx 6712 8 significantly significantly RB cord-010092-uftc8inx 6712 9 depending depend VBG cord-010092-uftc8inx 6712 10 on on IN cord-010092-uftc8inx 6712 11 the the DT cord-010092-uftc8inx 6712 12 intensity intensity NN cord-010092-uftc8inx 6712 13 and and CC cord-010092-uftc8inx 6712 14 time time NN cord-010092-uftc8inx 6712 15 of of IN cord-010092-uftc8inx 6712 16 exposure exposure NN cord-010092-uftc8inx 6712 17 . . . cord-010092-uftc8inx 6713 1 We -PRON- PRP cord-010092-uftc8inx 6713 2 observed observe VBD cord-010092-uftc8inx 6713 3 significant significant JJ cord-010092-uftc8inx 6713 4 changes change NNS cord-010092-uftc8inx 6713 5 in in IN cord-010092-uftc8inx 6713 6 the the DT cord-010092-uftc8inx 6713 7 spectrin spectrin NNP cord-010092-uftc8inx 6713 8 matrix matrix NN cord-010092-uftc8inx 6713 9 after after IN cord-010092-uftc8inx 6713 10 exposure exposure NN cord-010092-uftc8inx 6713 11 to to IN cord-010092-uftc8inx 6713 12 UV uv NN cord-010092-uftc8inx 6713 13 radiation radiation NN cord-010092-uftc8inx 6713 14 in in IN cord-010092-uftc8inx 6713 15 a a DT cord-010092-uftc8inx 6713 16 model model NN cord-010092-uftc8inx 6713 17 experiment experiment NN cord-010092-uftc8inx 6713 18 . . . cord-010092-uftc8inx 6714 1 The the DT cord-010092-uftc8inx 6714 2 local local JJ cord-010092-uftc8inx 6714 3 topological topological JJ cord-010092-uftc8inx 6714 4 defects defect NNS cord-010092-uftc8inx 6714 5 in in IN cord-010092-uftc8inx 6714 6 the the DT cord-010092-uftc8inx 6714 7 membrane membrane NN cord-010092-uftc8inx 6714 8 arise arise VBP cord-010092-uftc8inx 6714 9 from from IN cord-010092-uftc8inx 6714 10 the the DT cord-010092-uftc8inx 6714 11 action action NN cord-010092-uftc8inx 6714 12 of of IN cord-010092-uftc8inx 6714 13 oxidizing oxidize VBG cord-010092-uftc8inx 6714 14 agents agent NNS cord-010092-uftc8inx 6714 15 on on IN cord-010092-uftc8inx 6714 16 the the DT cord-010092-uftc8inx 6714 17 red red JJ cord-010092-uftc8inx 6714 18 blood blood NN cord-010092-uftc8inx 6714 19 cells cell NNS cord-010092-uftc8inx 6714 20 . . . cord-010092-uftc8inx 6715 1 The the DT cord-010092-uftc8inx 6715 2 mechanism mechanism NN cord-010092-uftc8inx 6715 3 of of IN cord-010092-uftc8inx 6715 4 their -PRON- PRP$ cord-010092-uftc8inx 6715 5 appearance appearance NN cord-010092-uftc8inx 6715 6 is be VBZ cord-010092-uftc8inx 6715 7 connected connect VBN cord-010092-uftc8inx 6715 8 mainly mainly RB cord-010092-uftc8inx 6715 9 with with IN cord-010092-uftc8inx 6715 10 the the DT cord-010092-uftc8inx 6715 11 distortion distortion NN cord-010092-uftc8inx 6715 12 of of IN cord-010092-uftc8inx 6715 13 the the DT cord-010092-uftc8inx 6715 14 spectrin spectrin NNP cord-010092-uftc8inx 6715 15 matrix matrix NN cord-010092-uftc8inx 6715 16 . . . cord-010092-uftc8inx 6716 1 As as IN cord-010092-uftc8inx 6716 2 a a DT cord-010092-uftc8inx 6716 3 result result NN cord-010092-uftc8inx 6716 4 of of IN cord-010092-uftc8inx 6716 5 oxidation oxidation NN cord-010092-uftc8inx 6716 6 processes process NNS cord-010092-uftc8inx 6716 7 , , , cord-010092-uftc8inx 6716 8 the the DT cord-010092-uftc8inx 6716 9 spectrin spectrin NNS cord-010092-uftc8inx 6716 10 molecules molecule NNS cord-010092-uftc8inx 6716 11 can can MD cord-010092-uftc8inx 6716 12 be be VB cord-010092-uftc8inx 6716 13 damaged damage VBN cord-010092-uftc8inx 6716 14 . . . cord-010092-uftc8inx 6717 1 There there EX cord-010092-uftc8inx 6717 2 is be VBZ cord-010092-uftc8inx 6717 3 a a DT cord-010092-uftc8inx 6717 4 transformation transformation NN cord-010092-uftc8inx 6717 5 of of IN cord-010092-uftc8inx 6717 6 tetramers tetramer NNS cord-010092-uftc8inx 6717 7 to to IN cord-010092-uftc8inx 6717 8 dimers dimer NNS cord-010092-uftc8inx 6717 9 . . . cord-010092-uftc8inx 6718 1 Additionally additionally RB cord-010092-uftc8inx 6718 2 , , , cord-010092-uftc8inx 6718 3 it -PRON- PRP cord-010092-uftc8inx 6718 4 can can MD cord-010092-uftc8inx 6718 5 be be VB cord-010092-uftc8inx 6718 6 easily easily RB cord-010092-uftc8inx 6718 7 seen see VBN cord-010092-uftc8inx 6718 8 with with IN cord-010092-uftc8inx 6718 9 the the DT cord-010092-uftc8inx 6718 10 AFM AFM NNP cord-010092-uftc8inx 6718 11 , , , cord-010092-uftc8inx 6718 12 that that WDT cord-010092-uftc8inx 6718 13 spectrin spectrin NNP cord-010092-uftc8inx 6718 14 network network NN cord-010092-uftc8inx 6718 15 structure structure NN cord-010092-uftc8inx 6718 16 was be VBD cord-010092-uftc8inx 6718 17 essentially essentially RB cord-010092-uftc8inx 6718 18 destroyed destroy VBN cord-010092-uftc8inx 6718 19 . . . cord-010092-uftc8inx 6719 1 Most Most JJS cord-010092-uftc8inx 6719 2 parts part NNS cord-010092-uftc8inx 6719 3 of of IN cord-010092-uftc8inx 6719 4 the the DT cord-010092-uftc8inx 6719 5 spectrin spectrin NNP cord-010092-uftc8inx 6719 6 matrix matrix NN cord-010092-uftc8inx 6719 7 have have VBP cord-010092-uftc8inx 6719 8 damaged damage VBN cord-010092-uftc8inx 6719 9 structures structure NNS cord-010092-uftc8inx 6719 10 with with IN cord-010092-uftc8inx 6719 11 mesh mesh NN cord-010092-uftc8inx 6719 12 breaks break NNS cord-010092-uftc8inx 6719 13 and and CC cord-010092-uftc8inx 6719 14 dips dip NNS cord-010092-uftc8inx 6719 15 after after IN cord-010092-uftc8inx 6719 16 UV uv NN cord-010092-uftc8inx 6719 17 irradiation irradiation NN cord-010092-uftc8inx 6719 18 . . . cord-010092-uftc8inx 6720 1 Also also RB cord-010092-uftc8inx 6720 2 the the DT cord-010092-uftc8inx 6720 3 results result NNS cord-010092-uftc8inx 6720 4 of of IN cord-010092-uftc8inx 6720 5 network network NN cord-010092-uftc8inx 6720 6 distortions distortion NNS cord-010092-uftc8inx 6720 7 in in IN cord-010092-uftc8inx 6720 8 response response NN cord-010092-uftc8inx 6720 9 to to IN cord-010092-uftc8inx 6720 10 temperature temperature NN cord-010092-uftc8inx 6720 11 changes change NNS cord-010092-uftc8inx 6720 12 were be VBD cord-010092-uftc8inx 6720 13 obtained obtain VBN cord-010092-uftc8inx 6720 14 . . . cord-010092-uftc8inx 6721 1 There there EX cord-010092-uftc8inx 6721 2 are be VBP cord-010092-uftc8inx 6721 3 presented present VBN cord-010092-uftc8inx 6721 4 preliminary preliminary JJ cord-010092-uftc8inx 6721 5 results result NNS cord-010092-uftc8inx 6721 6 of of IN cord-010092-uftc8inx 6721 7 spectrin spectrin NNS cord-010092-uftc8inx 6721 8 matrix matrix NN cord-010092-uftc8inx 6721 9 change change NN cord-010092-uftc8inx 6721 10 during during IN cord-010092-uftc8inx 6721 11 long long JJ cord-010092-uftc8inx 6721 12 - - HYPH cord-010092-uftc8inx 6721 13 term term NN cord-010092-uftc8inx 6721 14 storage storage NN cord-010092-uftc8inx 6721 15 of of IN cord-010092-uftc8inx 6721 16 pRBC prbc NN cord-010092-uftc8inx 6721 17 . . . cord-010092-uftc8inx 6722 1 Summary Summary NNP cord-010092-uftc8inx 6722 2 / / SYM cord-010092-uftc8inx 6722 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 6722 4 : : : cord-010092-uftc8inx 6723 1 Atomic atomic JJ cord-010092-uftc8inx 6723 2 force force NN cord-010092-uftc8inx 6723 3 microscopy microscopy NNS cord-010092-uftc8inx 6723 4 in in IN cord-010092-uftc8inx 6723 5 direct direct JJ cord-010092-uftc8inx 6723 6 biophysics biophysic NNS cord-010092-uftc8inx 6723 7 experiment experiment NN cord-010092-uftc8inx 6723 8 allows allow VBZ cord-010092-uftc8inx 6723 9 to to TO cord-010092-uftc8inx 6723 10 observe observe VB cord-010092-uftc8inx 6723 11 and and CC cord-010092-uftc8inx 6723 12 to to TO cord-010092-uftc8inx 6723 13 quantitatively quantitatively RB cord-010092-uftc8inx 6723 14 measure measure VB cord-010092-uftc8inx 6723 15 the the DT cord-010092-uftc8inx 6723 16 disturbances disturbance NNS cord-010092-uftc8inx 6723 17 in in IN cord-010092-uftc8inx 6723 18 the the DT cord-010092-uftc8inx 6723 19 spectrin spectrin NNP cord-010092-uftc8inx 6723 20 matrix matrix NNP cord-010092-uftc8inx 6723 21 nanostructure nanostructure NN cord-010092-uftc8inx 6723 22 in in IN cord-010092-uftc8inx 6723 23 response response NN cord-010092-uftc8inx 6723 24 to to IN cord-010092-uftc8inx 6723 25 oxidation oxidation NN cord-010092-uftc8inx 6723 26 processes process NNS cord-010092-uftc8inx 6723 27 in in IN cord-010092-uftc8inx 6723 28 RBCs rbc NNS cord-010092-uftc8inx 6723 29 . . . cord-010092-uftc8inx 6724 1 These these DT cord-010092-uftc8inx 6724 2 studies study NNS cord-010092-uftc8inx 6724 3 are be VBP cord-010092-uftc8inx 6724 4 important important JJ cord-010092-uftc8inx 6724 5 for for IN cord-010092-uftc8inx 6724 6 the the DT cord-010092-uftc8inx 6724 7 fundamental fundamental JJ cord-010092-uftc8inx 6724 8 research research NN cord-010092-uftc8inx 6724 9 of of IN cord-010092-uftc8inx 6724 10 interactions interaction NNS cord-010092-uftc8inx 6724 11 of of IN cord-010092-uftc8inx 6724 12 RBCs rbc NNS cord-010092-uftc8inx 6724 13 on on IN cord-010092-uftc8inx 6724 14 the the DT cord-010092-uftc8inx 6724 15 molecular molecular JJ cord-010092-uftc8inx 6724 16 level level NN cord-010092-uftc8inx 6724 17 during during IN cord-010092-uftc8inx 6724 18 redox redox JJ cord-010092-uftc8inx 6724 19 processes process NNS cord-010092-uftc8inx 6724 20 and and CC cord-010092-uftc8inx 6724 21 the the DT cord-010092-uftc8inx 6724 22 consequences consequence NNS cord-010092-uftc8inx 6724 23 to to IN cord-010092-uftc8inx 6724 24 their -PRON- PRP$ cord-010092-uftc8inx 6724 25 structure structure NN cord-010092-uftc8inx 6724 26 and and CC cord-010092-uftc8inx 6724 27 function function NN cord-010092-uftc8inx 6724 28 on on IN cord-010092-uftc8inx 6724 29 the the DT cord-010092-uftc8inx 6724 30 cellular cellular JJ cord-010092-uftc8inx 6724 31 level level NN cord-010092-uftc8inx 6724 32 . . . cord-010092-uftc8inx 6725 1 This this DT cord-010092-uftc8inx 6725 2 is be VBZ cord-010092-uftc8inx 6725 3 important important JJ cord-010092-uftc8inx 6725 4 for for IN cord-010092-uftc8inx 6725 5 the the DT cord-010092-uftc8inx 6725 6 advancement advancement NN cord-010092-uftc8inx 6725 7 of of IN cord-010092-uftc8inx 6725 8 transfusion transfusion NN cord-010092-uftc8inx 6725 9 medicine medicine NN cord-010092-uftc8inx 6725 10 , , , cord-010092-uftc8inx 6725 11 intensive intensive JJ cord-010092-uftc8inx 6725 12 care care NN cord-010092-uftc8inx 6725 13 medicine medicine NN cord-010092-uftc8inx 6725 14 , , , cord-010092-uftc8inx 6725 15 and and CC cord-010092-uftc8inx 6725 16 molecular molecular JJ cord-010092-uftc8inx 6725 17 and and CC cord-010092-uftc8inx 6725 18 radiation radiation NN cord-010092-uftc8inx 6725 19 biology biology NN cord-010092-uftc8inx 6725 20 . . . cord-010092-uftc8inx 6726 1 Methods method NNS cord-010092-uftc8inx 6726 2 : : : cord-010092-uftc8inx 6726 3 Blood blood NN cord-010092-uftc8inx 6726 4 samples sample NNS cord-010092-uftc8inx 6726 5 were be VBD cord-010092-uftc8inx 6726 6 taken take VBN cord-010092-uftc8inx 6726 7 from from IN cord-010092-uftc8inx 6726 8 8 8 CD cord-010092-uftc8inx 6726 9 donors donor NNS cord-010092-uftc8inx 6726 10 during during IN cord-010092-uftc8inx 6726 11 a a DT cord-010092-uftc8inx 6726 12 prophylactic prophylactic JJ cord-010092-uftc8inx 6726 13 examination examination NN cord-010092-uftc8inx 6726 14 and and CC cord-010092-uftc8inx 6726 15 collected collect VBN cord-010092-uftc8inx 6726 16 with with IN cord-010092-uftc8inx 6726 17 EDTA EDTA NNP cord-010092-uftc8inx 6726 18 - - HYPH cord-010092-uftc8inx 6726 19 filled fill VBN cord-010092-uftc8inx 6726 20 microvettes microvette NNS cord-010092-uftc8inx 6726 21 ( ( -LRB- cord-010092-uftc8inx 6726 22 Sarstedt Sarstedt NNP cord-010092-uftc8inx 6726 23 AG AG NNP cord-010092-uftc8inx 6726 24 and and CC cord-010092-uftc8inx 6726 25 Co. Co. NNP cord-010092-uftc8inx 6726 26 , , , cord-010092-uftc8inx 6726 27 Germany Germany NNP cord-010092-uftc8inx 6726 28 ) ) -RRB- cord-010092-uftc8inx 6726 29 . . . cord-010092-uftc8inx 6727 1 All all DT cord-010092-uftc8inx 6727 2 experiments experiment NNS cord-010092-uftc8inx 6727 3 were be VBD cord-010092-uftc8inx 6727 4 carried carry VBN cord-010092-uftc8inx 6727 5 out out RP cord-010092-uftc8inx 6727 6 in in IN cord-010092-uftc8inx 6727 7 accordance accordance NN cord-010092-uftc8inx 6727 8 with with IN cord-010092-uftc8inx 6727 9 the the DT cord-010092-uftc8inx 6727 10 Institute Institute NNP cord-010092-uftc8inx 6727 11 guidelines guideline NNS cord-010092-uftc8inx 6727 12 and and CC cord-010092-uftc8inx 6727 13 regulations regulation NNS cord-010092-uftc8inx 6727 14 . . . cord-010092-uftc8inx 6728 1 The the DT cord-010092-uftc8inx 6728 2 polylysine polylysine NN cord-010092-uftc8inx 6728 3 - - HYPH cord-010092-uftc8inx 6728 4 coated coat VBN cord-010092-uftc8inx 6728 5 glass glass NN cord-010092-uftc8inx 6728 6 was be VBD cord-010092-uftc8inx 6728 7 used use VBN cord-010092-uftc8inx 6728 8 to to TO cord-010092-uftc8inx 6728 9 perform perform VB cord-010092-uftc8inx 6728 10 the the DT cord-010092-uftc8inx 6728 11 sedimentation sedimentation NN cord-010092-uftc8inx 6728 12 method method NN cord-010092-uftc8inx 6728 13 for for IN cord-010092-uftc8inx 6728 14 formation formation NN cord-010092-uftc8inx 6728 15 of of IN cord-010092-uftc8inx 6728 16 native native JJ cord-010092-uftc8inx 6728 17 RBC RBC NNP cord-010092-uftc8inx 6728 18 smears smear NNS cord-010092-uftc8inx 6728 19 . . . cord-010092-uftc8inx 6729 1 It -PRON- PRP cord-010092-uftc8inx 6729 2 is be VBZ cord-010092-uftc8inx 6729 3 important important JJ cord-010092-uftc8inx 6729 4 that that IN cord-010092-uftc8inx 6729 5 any any DT cord-010092-uftc8inx 6729 6 fixatives fixative NNS cord-010092-uftc8inx 6729 7 were be VBD cord-010092-uftc8inx 6729 8 n't not RB cord-010092-uftc8inx 6729 9 used use VBN cord-010092-uftc8inx 6729 10 . . . cord-010092-uftc8inx 6730 1 The the DT cord-010092-uftc8inx 6730 2 stiffness stiffness NN cord-010092-uftc8inx 6730 3 of of IN cord-010092-uftc8inx 6730 4 RBC RBC NNP cord-010092-uftc8inx 6730 5 membranes membrane NNS cord-010092-uftc8inx 6730 6 was be VBD cord-010092-uftc8inx 6730 7 studied study VBN cord-010092-uftc8inx 6730 8 in in IN cord-010092-uftc8inx 6730 9 native native JJ cord-010092-uftc8inx 6730 10 RBCs rbc NNS cord-010092-uftc8inx 6730 11 ( ( -LRB- cord-010092-uftc8inx 6730 12 control control NN cord-010092-uftc8inx 6730 13 ) ) -RRB- cord-010092-uftc8inx 6730 14 and and CC cord-010092-uftc8inx 6730 15 native native JJ cord-010092-uftc8inx 6730 16 cells cell NNS cord-010092-uftc8inx 6730 17 after after IN cord-010092-uftc8inx 6730 18 the the DT cord-010092-uftc8inx 6730 19 application application NN cord-010092-uftc8inx 6730 20 of of IN cord-010092-uftc8inx 6730 21 modifiers modifier NNS cord-010092-uftc8inx 6730 22 : : : cord-010092-uftc8inx 6731 1 glutaraldehyde glutaraldehyde NNP cord-010092-uftc8inx 6731 2 , , , cord-010092-uftc8inx 6731 3 hemin hemin NNP cord-010092-uftc8inx 6731 4 , , , cord-010092-uftc8inx 6731 5 Zn Zn NNP cord-010092-uftc8inx 6731 6 2 2 CD cord-010092-uftc8inx 6731 7 + + CC cord-010092-uftc8inx 6731 8 ( ( -LRB- cord-010092-uftc8inx 6731 9 heavy heavy JJ cord-010092-uftc8inx 6731 10 metal metal NN cord-010092-uftc8inx 6731 11 ions ion NNS cord-010092-uftc8inx 6731 12 ) ) -RRB- cord-010092-uftc8inx 6731 13 . . . cord-010092-uftc8inx 6732 1 Local local JJ cord-010092-uftc8inx 6732 2 stiffness stiffness NN cord-010092-uftc8inx 6732 3 was be VBD cord-010092-uftc8inx 6732 4 studied study VBN cord-010092-uftc8inx 6732 5 by by IN cord-010092-uftc8inx 6732 6 atomic atomic JJ cord-010092-uftc8inx 6732 7 force force NN cord-010092-uftc8inx 6732 8 spectroscopy spectroscopy NN cord-010092-uftc8inx 6732 9 ( ( -LRB- cord-010092-uftc8inx 6732 10 AFS AFS NNP cord-010092-uftc8inx 6732 11 ) ) -RRB- cord-010092-uftc8inx 6732 12 ( ( -LRB- cord-010092-uftc8inx 6732 13 NTEGRA NTEGRA NNP cord-010092-uftc8inx 6732 14 Prima Prima NNP cord-010092-uftc8inx 6732 15 , , , cord-010092-uftc8inx 6732 16 ( ( -LRB- cord-010092-uftc8inx 6732 17 NT NT NNP cord-010092-uftc8inx 6732 18 - - HYPH cord-010092-uftc8inx 6732 19 MDT MDT NNP cord-010092-uftc8inx 6732 20 , , , cord-010092-uftc8inx 6732 21 Russian Russian NNP cord-010092-uftc8inx 6732 22 Federation Federation NNP cord-010092-uftc8inx 6732 23 ) ) -RRB- cord-010092-uftc8inx 6732 24 . . . cord-010092-uftc8inx 6733 1 Results result NNS cord-010092-uftc8inx 6733 2 : : : cord-010092-uftc8inx 6733 3 Experimental experimental JJ cord-010092-uftc8inx 6733 4 kinetic kinetic JJ cord-010092-uftc8inx 6733 5 curves curve NNS cord-010092-uftc8inx 6733 6 I(z I(z NNP cord-010092-uftc8inx 6733 7 ) ) -RRB- cord-010092-uftc8inx 6733 8 were be VBD cord-010092-uftc8inx 6733 9 measured measure VBN cord-010092-uftc8inx 6733 10 . . . cord-010092-uftc8inx 6734 1 Nonlinear nonlinear JJ cord-010092-uftc8inx 6734 2 fitting fitting JJ cord-010092-uftc8inx 6734 3 method method NN cord-010092-uftc8inx 6734 4 was be VBD cord-010092-uftc8inx 6734 5 used use VBN cord-010092-uftc8inx 6734 6 to to TO cord-010092-uftc8inx 6734 7 determine determine VB cord-010092-uftc8inx 6734 8 the the DT cord-010092-uftc8inx 6734 9 Young Young NNP cord-010092-uftc8inx 6734 10 's 's POS cord-010092-uftc8inx 6734 11 modulus modulus NN cord-010092-uftc8inx 6734 12 . . . cord-010092-uftc8inx 6735 1 The the DT cord-010092-uftc8inx 6735 2 experimental experimental JJ cord-010092-uftc8inx 6735 3 dependences dependence NNS cord-010092-uftc8inx 6735 4 of of IN cord-010092-uftc8inx 6735 5 membrane membrane NN cord-010092-uftc8inx 6735 6 bending bend VBG cord-010092-uftc8inx 6735 7 were be VBD cord-010092-uftc8inx 6735 8 approximated approximate VBN cord-010092-uftc8inx 6735 9 by by IN cord-010092-uftc8inx 6735 10 the the DT cord-010092-uftc8inx 6735 11 Hertz Hertz NNP cord-010092-uftc8inx 6735 12 model model NN cord-010092-uftc8inx 6735 13 to to IN cord-010092-uftc8inx 6735 14 a a DT cord-010092-uftc8inx 6735 15 depth depth NN cord-010092-uftc8inx 6735 16 up up IN cord-010092-uftc8inx 6735 17 to to IN cord-010092-uftc8inx 6735 18 600 600 CD cord-010092-uftc8inx 6735 19 nm nm NN cord-010092-uftc8inx 6735 20 . . . cord-010092-uftc8inx 6736 1 The the DT cord-010092-uftc8inx 6736 2 Young Young NNP cord-010092-uftc8inx 6736 3 's 's POS cord-010092-uftc8inx 6736 4 modulus modulus NN cord-010092-uftc8inx 6736 5 E e NN cord-010092-uftc8inx 6736 6 = = SYM cord-010092-uftc8inx 6736 7 10 10 CD cord-010092-uftc8inx 6736 8 AE AE NNP cord-010092-uftc8inx 6736 9 5 5 CD cord-010092-uftc8inx 6736 10 kPa kPa NNS cord-010092-uftc8inx 6736 11 for for IN cord-010092-uftc8inx 6736 12 control control NNP cord-010092-uftc8inx 6736 13 RBC RBC NNP cord-010092-uftc8inx 6736 14 . . . cord-010092-uftc8inx 6737 1 It -PRON- PRP cord-010092-uftc8inx 6737 2 was be VBD cord-010092-uftc8inx 6737 3 shown show VBN cord-010092-uftc8inx 6737 4 that that IN cord-010092-uftc8inx 6737 5 some some DT cord-010092-uftc8inx 6737 6 natural natural JJ cord-010092-uftc8inx 6737 7 oxidants oxidant NNS cord-010092-uftc8inx 6737 8 ( ( -LRB- cord-010092-uftc8inx 6737 9 hemin hemin NNP cord-010092-uftc8inx 6737 10 ) ) -RRB- cord-010092-uftc8inx 6737 11 , , , cord-010092-uftc8inx 6737 12 membrane membrane NN cord-010092-uftc8inx 6737 13 fixatives fixatives NNP cord-010092-uftc8inx 6737 14 ( ( -LRB- cord-010092-uftc8inx 6737 15 glutaraldehyde glutaraldehyde NN cord-010092-uftc8inx 6737 16 ) ) -RRB- cord-010092-uftc8inx 6737 17 modifiers modifier NNS cord-010092-uftc8inx 6737 18 , , , cord-010092-uftc8inx 6737 19 heavy heavy JJ cord-010092-uftc8inx 6737 20 metal metal NN cord-010092-uftc8inx 6737 21 ions ion NNS cord-010092-uftc8inx 6737 22 ( ( -LRB- cord-010092-uftc8inx 6737 23 Zn Zn NNP cord-010092-uftc8inx 6737 24 2 2 CD cord-010092-uftc8inx 6737 25 + + SYM cord-010092-uftc8inx 6737 26 ) ) -RRB- cord-010092-uftc8inx 6737 27 significantly significantly RB cord-010092-uftc8inx 6737 28 increased increase VBD cord-010092-uftc8inx 6737 29 the the DT cord-010092-uftc8inx 6737 30 absolute absolute JJ cord-010092-uftc8inx 6737 31 value value NN cord-010092-uftc8inx 6737 32 of of IN cord-010092-uftc8inx 6737 33 the the DT cord-010092-uftc8inx 6737 34 Young Young NNP cord-010092-uftc8inx 6737 35 's 's POS cord-010092-uftc8inx 6737 36 modulus modulus NN cord-010092-uftc8inx 6737 37 of of IN cord-010092-uftc8inx 6737 38 RBC RBC NNP cord-010092-uftc8inx 6737 39 membranes membrane NNS cord-010092-uftc8inx 6737 40 up up RP cord-010092-uftc8inx 6737 41 2 2 CD cord-010092-uftc8inx 6737 42 - - SYM cord-010092-uftc8inx 6737 43 3 3 CD cord-010092-uftc8inx 6737 44 times time NNS cord-010092-uftc8inx 6737 45 . . . cord-010092-uftc8inx 6738 1 The the DT cord-010092-uftc8inx 6738 2 biophysical biophysical JJ cord-010092-uftc8inx 6738 3 parameter parameter NN cord-010092-uftc8inx 6738 4 Hertz Hertz NNP cord-010092-uftc8inx 6738 5 depth depth NN cord-010092-uftc8inx 6738 6 ( ( -LRB- cord-010092-uftc8inx 6738 7 h h NN cord-010092-uftc8inx 6738 8 Hz Hz NNP cord-010092-uftc8inx 6738 9 ) ) -RRB- cord-010092-uftc8inx 6738 10 was be VBD cord-010092-uftc8inx 6738 11 determined determine VBN cord-010092-uftc8inx 6738 12 for for IN cord-010092-uftc8inx 6738 13 each each DT cord-010092-uftc8inx 6738 14 curve curve NN cord-010092-uftc8inx 6738 15 . . . cord-010092-uftc8inx 6739 1 Under under IN cord-010092-uftc8inx 6739 2 the the DT cord-010092-uftc8inx 6739 3 influence influence NN cord-010092-uftc8inx 6739 4 of of IN cord-010092-uftc8inx 6739 5 modifiers modifier NNS cord-010092-uftc8inx 6739 6 the the DT cord-010092-uftc8inx 6739 7 Hertz Hertz NNP cord-010092-uftc8inx 6739 8 depth depth NN cord-010092-uftc8inx 6739 9 h h NN cord-010092-uftc8inx 6739 10 Hz Hz NNP cord-010092-uftc8inx 6739 11 was be VBD cord-010092-uftc8inx 6739 12 changed change VBN cord-010092-uftc8inx 6739 13 from from IN cord-010092-uftc8inx 6739 14 200 200 CD cord-010092-uftc8inx 6739 15 nm nm NN cord-010092-uftc8inx 6739 16 to to IN cord-010092-uftc8inx 6739 17 600 600 CD cord-010092-uftc8inx 6739 18 nm nm NN cord-010092-uftc8inx 6739 19 . . . cord-010092-uftc8inx 6740 1 There there EX cord-010092-uftc8inx 6740 2 are be VBP cord-010092-uftc8inx 6740 3 presented present VBN cord-010092-uftc8inx 6740 4 preliminary preliminary JJ cord-010092-uftc8inx 6740 5 results result NNS cord-010092-uftc8inx 6740 6 during during IN cord-010092-uftc8inx 6740 7 long long JJ cord-010092-uftc8inx 6740 8 - - HYPH cord-010092-uftc8inx 6740 9 term term NN cord-010092-uftc8inx 6740 10 storage storage NN cord-010092-uftc8inx 6740 11 of of IN cord-010092-uftc8inx 6740 12 blood blood NN cord-010092-uftc8inx 6740 13 . . . cord-010092-uftc8inx 6741 1 Summary Summary NNP cord-010092-uftc8inx 6741 2 / / SYM cord-010092-uftc8inx 6741 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 6741 4 : : : cord-010092-uftc8inx 6742 1 The the DT cord-010092-uftc8inx 6742 2 blood blood NN cord-010092-uftc8inx 6742 3 rheology rheology NN cord-010092-uftc8inx 6742 4 is be VBZ cord-010092-uftc8inx 6742 5 determined determine VBN cord-010092-uftc8inx 6742 6 by by IN cord-010092-uftc8inx 6742 7 RBC RBC NNP cord-010092-uftc8inx 6742 8 deformability deformability NN cord-010092-uftc8inx 6742 9 , , , cord-010092-uftc8inx 6742 10 associated associate VBN cord-010092-uftc8inx 6742 11 with with IN cord-010092-uftc8inx 6742 12 membrane membrane NN cord-010092-uftc8inx 6742 13 stiffness stiffness NN cord-010092-uftc8inx 6742 14 . . . cord-010092-uftc8inx 6743 1 The the DT cord-010092-uftc8inx 6743 2 Young Young NNP cord-010092-uftc8inx 6743 3 's 's POS cord-010092-uftc8inx 6743 4 modulus modulus NN cord-010092-uftc8inx 6743 5 can can MD cord-010092-uftc8inx 6743 6 be be VB cord-010092-uftc8inx 6743 7 used use VBN cord-010092-uftc8inx 6743 8 as as IN cord-010092-uftc8inx 6743 9 a a DT cord-010092-uftc8inx 6743 10 quantitative quantitative JJ cord-010092-uftc8inx 6743 11 criterion criterion NN cord-010092-uftc8inx 6743 12 to to TO cord-010092-uftc8inx 6743 13 estimate estimate VB cord-010092-uftc8inx 6743 14 the the DT cord-010092-uftc8inx 6743 15 membrane membrane NN cord-010092-uftc8inx 6743 16 state state NN cord-010092-uftc8inx 6743 17 of of IN cord-010092-uftc8inx 6743 18 a a DT cord-010092-uftc8inx 6743 19 native native JJ cord-010092-uftc8inx 6743 20 cell cell NN cord-010092-uftc8inx 6743 21 . . . cord-010092-uftc8inx 6744 1 The the DT cord-010092-uftc8inx 6744 2 results result NNS cord-010092-uftc8inx 6744 3 of of IN cord-010092-uftc8inx 6744 4 the the DT cord-010092-uftc8inx 6744 5 work work NN cord-010092-uftc8inx 6744 6 can can MD cord-010092-uftc8inx 6744 7 be be VB cord-010092-uftc8inx 6744 8 used use VBN cord-010092-uftc8inx 6744 9 in in IN cord-010092-uftc8inx 6744 10 clinical clinical JJ cord-010092-uftc8inx 6744 11 practice practice NN cord-010092-uftc8inx 6744 12 , , , cord-010092-uftc8inx 6744 13 in in IN cord-010092-uftc8inx 6744 14 assessment assessment NN cord-010092-uftc8inx 6744 15 of of IN cord-010092-uftc8inx 6744 16 the the DT cord-010092-uftc8inx 6744 17 quality quality NN cord-010092-uftc8inx 6744 18 of of IN cord-010092-uftc8inx 6744 19 donor donor NN cord-010092-uftc8inx 6744 20 blood blood NN cord-010092-uftc8inx 6744 21 during during IN cord-010092-uftc8inx 6744 22 storage storage NN cord-010092-uftc8inx 6744 23 before before IN cord-010092-uftc8inx 6744 24 transfusion transfusion NN cord-010092-uftc8inx 6744 25 , , , cord-010092-uftc8inx 6744 26 in in IN cord-010092-uftc8inx 6744 27 biophysical biophysical JJ cord-010092-uftc8inx 6744 28 studies study NNS cord-010092-uftc8inx 6744 29 of of IN cord-010092-uftc8inx 6744 30 RBC RBC NNP cord-010092-uftc8inx 6744 31 state state NN cord-010092-uftc8inx 6744 32 . . . cord-010092-uftc8inx 6745 1 Abstract Abstract NNP cord-010092-uftc8inx 6745 2 withdrawn withdraw VBN cord-010092-uftc8inx 6745 3 . . . cord-010092-uftc8inx 6746 1 Immunohemotherapy Immunohemotherapy NNP cord-010092-uftc8inx 6746 2 , , , cord-010092-uftc8inx 6746 3 Centro Centro NNP cord-010092-uftc8inx 6746 4 Hospitalar Hospitalar NNP cord-010092-uftc8inx 6746 5 Universit Universit NNP cord-010092-uftc8inx 6746 6 ario ario NN cord-010092-uftc8inx 6746 7 São São NNP cord-010092-uftc8inx 6746 8 João João NNP cord-010092-uftc8inx 6746 9 , , , cord-010092-uftc8inx 6746 10 EPE EPE NNP cord-010092-uftc8inx 6746 11 , , , cord-010092-uftc8inx 6746 12 Porto Porto NNP cord-010092-uftc8inx 6746 13 , , , cord-010092-uftc8inx 6746 14 Portugal Portugal NNP cord-010092-uftc8inx 6746 15 Background Background NNP cord-010092-uftc8inx 6746 16 : : : cord-010092-uftc8inx 6746 17 Transfusion transfusion NN cord-010092-uftc8inx 6746 18 of of IN cord-010092-uftc8inx 6746 19 blood blood NN cord-010092-uftc8inx 6746 20 and and CC cord-010092-uftc8inx 6746 21 blood blood NN cord-010092-uftc8inx 6746 22 components component NNS cord-010092-uftc8inx 6746 23 is be VBZ cord-010092-uftc8inx 6746 24 an an DT cord-010092-uftc8inx 6746 25 essential essential JJ cord-010092-uftc8inx 6746 26 resource resource NN cord-010092-uftc8inx 6746 27 in in IN cord-010092-uftc8inx 6746 28 modern modern JJ cord-010092-uftc8inx 6746 29 medicine medicine NN cord-010092-uftc8inx 6746 30 . . . cord-010092-uftc8inx 6747 1 A a DT cord-010092-uftc8inx 6747 2 proper proper JJ cord-010092-uftc8inx 6747 3 use use NN cord-010092-uftc8inx 6747 4 of of IN cord-010092-uftc8inx 6747 5 human human JJ cord-010092-uftc8inx 6747 6 blood blood NN cord-010092-uftc8inx 6747 7 , , , cord-010092-uftc8inx 6747 8 being be VBG cord-010092-uftc8inx 6747 9 an an DT cord-010092-uftc8inx 6747 10 irreplaceable irreplaceable JJ cord-010092-uftc8inx 6747 11 resource resource NN cord-010092-uftc8inx 6747 12 , , , cord-010092-uftc8inx 6747 13 is be VBZ cord-010092-uftc8inx 6747 14 necessary necessary JJ cord-010092-uftc8inx 6747 15 in in IN cord-010092-uftc8inx 6747 16 order order NN cord-010092-uftc8inx 6747 17 to to TO cord-010092-uftc8inx 6747 18 achieve achieve VB cord-010092-uftc8inx 6747 19 minimal minimal JJ cord-010092-uftc8inx 6747 20 wastage wastage NN cord-010092-uftc8inx 6747 21 . . . cord-010092-uftc8inx 6748 1 Blood blood NN cord-010092-uftc8inx 6748 2 wastage wastage NN cord-010092-uftc8inx 6748 3 may may MD cord-010092-uftc8inx 6748 4 occur occur VB cord-010092-uftc8inx 6748 5 for for IN cord-010092-uftc8inx 6748 6 a a DT cord-010092-uftc8inx 6748 7 number number NN cord-010092-uftc8inx 6748 8 of of IN cord-010092-uftc8inx 6748 9 reasons reason NNS cord-010092-uftc8inx 6748 10 , , , cord-010092-uftc8inx 6748 11 like like IN cord-010092-uftc8inx 6748 12 expiry expiry NN cord-010092-uftc8inx 6748 13 date date NN cord-010092-uftc8inx 6748 14 , , , cord-010092-uftc8inx 6748 15 haemolysis haemolysis NN cord-010092-uftc8inx 6748 16 , , , cord-010092-uftc8inx 6748 17 seroreactivity seroreactivity NN cord-010092-uftc8inx 6748 18 or or CC cord-010092-uftc8inx 6748 19 low low JJ cord-010092-uftc8inx 6748 20 volume volume NN cord-010092-uftc8inx 6748 21 . . . cord-010092-uftc8inx 6749 1 Monitoring monitor VBG cord-010092-uftc8inx 6749 2 wastage wastage NN cord-010092-uftc8inx 6749 3 of of IN cord-010092-uftc8inx 6749 4 blood blood NN cord-010092-uftc8inx 6749 5 product product NN cord-010092-uftc8inx 6749 6 during during IN cord-010092-uftc8inx 6749 7 collection collection NN cord-010092-uftc8inx 6749 8 , , , cord-010092-uftc8inx 6749 9 testing testing NN cord-010092-uftc8inx 6749 10 and and CC cord-010092-uftc8inx 6749 11 processing processing NN cord-010092-uftc8inx 6749 12 of of IN cord-010092-uftc8inx 6749 13 blood blood NN cord-010092-uftc8inx 6749 14 is be VBZ cord-010092-uftc8inx 6749 15 used use VBN cord-010092-uftc8inx 6749 16 as as IN cord-010092-uftc8inx 6749 17 a a DT cord-010092-uftc8inx 6749 18 quality quality NN cord-010092-uftc8inx 6749 19 indicator indicator NN cord-010092-uftc8inx 6749 20 . . . cord-010092-uftc8inx 6750 1 Aims aim VBZ cord-010092-uftc8inx 6750 2 : : : cord-010092-uftc8inx 6750 3 To to TO cord-010092-uftc8inx 6750 4 determine determine VB cord-010092-uftc8inx 6750 5 the the DT cord-010092-uftc8inx 6750 6 annual annual JJ cord-010092-uftc8inx 6750 7 rate rate NN cord-010092-uftc8inx 6750 8 of of IN cord-010092-uftc8inx 6750 9 discarded discard VBN cord-010092-uftc8inx 6750 10 blood blood NN cord-010092-uftc8inx 6750 11 components component NNS cord-010092-uftc8inx 6750 12 due due JJ cord-010092-uftc8inx 6750 13 to to IN cord-010092-uftc8inx 6750 14 expiry expiry NN cord-010092-uftc8inx 6750 15 date date NN cord-010092-uftc8inx 6750 16 in in IN cord-010092-uftc8inx 6750 17 a a DT cord-010092-uftc8inx 6750 18 Portuguese Portuguese NNP cord-010092-uftc8inx 6750 19 University University NNP cord-010092-uftc8inx 6750 20 Hospital Hospital NNP cord-010092-uftc8inx 6750 21 Blood Blood NNP cord-010092-uftc8inx 6750 22 Bank Bank NNP cord-010092-uftc8inx 6750 23 ( ( -LRB- cord-010092-uftc8inx 6750 24 BB BB NNP cord-010092-uftc8inx 6750 25 ) ) -RRB- cord-010092-uftc8inx 6750 26 from from IN cord-010092-uftc8inx 6750 27 January January NNP cord-010092-uftc8inx 6750 28 2016 2016 CD cord-010092-uftc8inx 6750 29 to to IN cord-010092-uftc8inx 6750 30 December December NNP cord-010092-uftc8inx 6750 31 2018 2018 CD cord-010092-uftc8inx 6750 32 , , , cord-010092-uftc8inx 6750 33 in in IN cord-010092-uftc8inx 6750 34 order order NN cord-010092-uftc8inx 6750 35 to to TO cord-010092-uftc8inx 6750 36 implement implement VB cord-010092-uftc8inx 6750 37 appropriate appropriate JJ cord-010092-uftc8inx 6750 38 measures measure NNS cord-010092-uftc8inx 6750 39 to to TO cord-010092-uftc8inx 6750 40 minimize minimize VB cord-010092-uftc8inx 6750 41 the the DT cord-010092-uftc8inx 6750 42 number number NN cord-010092-uftc8inx 6750 43 of of IN cord-010092-uftc8inx 6750 44 discarded discard VBN cord-010092-uftc8inx 6750 45 blood blood NN cord-010092-uftc8inx 6750 46 to to IN cord-010092-uftc8inx 6750 47 a a DT cord-010092-uftc8inx 6750 48 reasonable reasonable JJ cord-010092-uftc8inx 6750 49 rate rate NN cord-010092-uftc8inx 6750 50 . . . cord-010092-uftc8inx 6751 1 Methods method NNS cord-010092-uftc8inx 6752 1 : : : cord-010092-uftc8inx 6752 2 We -PRON- PRP cord-010092-uftc8inx 6752 3 retrospectively retrospectively RB cord-010092-uftc8inx 6752 4 analysed analyse VBD cord-010092-uftc8inx 6752 5 the the DT cord-010092-uftc8inx 6752 6 rates rate NNS cord-010092-uftc8inx 6752 7 of of IN cord-010092-uftc8inx 6752 8 blood blood NN cord-010092-uftc8inx 6752 9 components component NNS cord-010092-uftc8inx 6752 10 discarded discard VBN cord-010092-uftc8inx 6752 11 after after IN cord-010092-uftc8inx 6752 12 meeting meet VBG cord-010092-uftc8inx 6752 13 their -PRON- PRP$ cord-010092-uftc8inx 6752 14 expiry expiry NN cord-010092-uftc8inx 6752 15 date date NN cord-010092-uftc8inx 6752 16 of of IN cord-010092-uftc8inx 6752 17 a a DT cord-010092-uftc8inx 6752 18 Portuguese Portuguese NNP cord-010092-uftc8inx 6752 19 University University NNP cord-010092-uftc8inx 6752 20 Hospital Hospital NNP cord-010092-uftc8inx 6752 21 Blood Blood NNP cord-010092-uftc8inx 6752 22 Bank Bank NNP cord-010092-uftc8inx 6752 23 from from IN cord-010092-uftc8inx 6752 24 January January NNP cord-010092-uftc8inx 6752 25 1st 1st NN cord-010092-uftc8inx 6752 26 2016 2016 CD cord-010092-uftc8inx 6752 27 to to IN cord-010092-uftc8inx 6752 28 December December NNP cord-010092-uftc8inx 6752 29 31st 31st NN cord-010092-uftc8inx 6752 30 2018 2018 CD cord-010092-uftc8inx 6752 31 . . . cord-010092-uftc8inx 6753 1 Results result NNS cord-010092-uftc8inx 6753 2 : : : cord-010092-uftc8inx 6754 1 A a DT cord-010092-uftc8inx 6754 2 total total NN cord-010092-uftc8inx 6754 3 of of IN cord-010092-uftc8inx 6754 4 54,599 54,599 CD cord-010092-uftc8inx 6754 5 whole whole JJ cord-010092-uftc8inx 6754 6 blood blood NN cord-010092-uftc8inx 6754 7 units unit NNS cord-010092-uftc8inx 6754 8 and and CC cord-010092-uftc8inx 6754 9 3,166 3,166 CD cord-010092-uftc8inx 6754 10 apheresis apheresis NN cord-010092-uftc8inx 6754 11 platelets platelet NNS cord-010092-uftc8inx 6754 12 were be VBD cord-010092-uftc8inx 6754 13 collected collect VBN cord-010092-uftc8inx 6754 14 during during IN cord-010092-uftc8inx 6754 15 the the DT cord-010092-uftc8inx 6754 16 study study NN cord-010092-uftc8inx 6754 17 period period NN cord-010092-uftc8inx 6754 18 . . . cord-010092-uftc8inx 6755 1 Of of IN cord-010092-uftc8inx 6755 2 the the DT cord-010092-uftc8inx 6755 3 66,289 66,289 CD cord-010092-uftc8inx 6755 4 blood blood NN cord-010092-uftc8inx 6755 5 components component NNS cord-010092-uftc8inx 6755 6 ( ( -LRB- cord-010092-uftc8inx 6755 7 packed pack VBN cord-010092-uftc8inx 6755 8 red red JJ cord-010092-uftc8inx 6755 9 cells cell NNS cord-010092-uftc8inx 6755 10 , , , cord-010092-uftc8inx 6755 11 whole whole JJ cord-010092-uftc8inx 6755 12 blood blood NN cord-010092-uftc8inx 6755 13 pooled pool VBD cord-010092-uftc8inx 6755 14 platelets platelet NNS cord-010092-uftc8inx 6755 15 and and CC cord-010092-uftc8inx 6755 16 apheresis apheresis NN cord-010092-uftc8inx 6755 17 platelets platelet NNS cord-010092-uftc8inx 6755 18 ) ) -RRB- cord-010092-uftc8inx 6755 19 prepared prepare VBD cord-010092-uftc8inx 6755 20 during during IN cord-010092-uftc8inx 6755 21 the the DT cord-010092-uftc8inx 6755 22 study study NN cord-010092-uftc8inx 6755 23 period period NN cord-010092-uftc8inx 6755 24 , , , cord-010092-uftc8inx 6755 25 a a DT cord-010092-uftc8inx 6755 26 total total NN cord-010092-uftc8inx 6755 27 of of IN cord-010092-uftc8inx 6755 28 2,891 2,891 CD cord-010092-uftc8inx 6755 29 ( ( -LRB- cord-010092-uftc8inx 6755 30 4.4 4.4 CD cord-010092-uftc8inx 6755 31 % % NN cord-010092-uftc8inx 6755 32 ) ) -RRB- cord-010092-uftc8inx 6756 1 blood blood NN cord-010092-uftc8inx 6756 2 components component NNS cord-010092-uftc8inx 6756 3 were be VBD cord-010092-uftc8inx 6756 4 discarded discard VBN cord-010092-uftc8inx 6756 5 , , , cord-010092-uftc8inx 6756 6 of of IN cord-010092-uftc8inx 6756 7 those those DT cord-010092-uftc8inx 6756 8 75.4 75.4 CD cord-010092-uftc8inx 6756 9 % % NN cord-010092-uftc8inx 6756 10 due due JJ cord-010092-uftc8inx 6756 11 to to IN cord-010092-uftc8inx 6756 12 expiry expiry NN cord-010092-uftc8inx 6756 13 date date NN cord-010092-uftc8inx 6756 14 . . . cord-010092-uftc8inx 6757 1 The the DT cord-010092-uftc8inx 6757 2 rate rate NN cord-010092-uftc8inx 6757 3 of of IN cord-010092-uftc8inx 6757 4 discarded discard VBN cord-010092-uftc8inx 6757 5 packed pack VBN cord-010092-uftc8inx 6757 6 red red JJ cord-010092-uftc8inx 6757 7 cells cell NNS cord-010092-uftc8inx 6757 8 , , , cord-010092-uftc8inx 6757 9 according accord VBG cord-010092-uftc8inx 6757 10 to to IN cord-010092-uftc8inx 6757 11 this this DT cord-010092-uftc8inx 6757 12 component component NN cord-010092-uftc8inx 6757 13 production production NN cord-010092-uftc8inx 6757 14 , , , cord-010092-uftc8inx 6757 15 decreased decrease VBD cord-010092-uftc8inx 6757 16 considerably considerably RB cord-010092-uftc8inx 6757 17 over over IN cord-010092-uftc8inx 6757 18 the the DT cord-010092-uftc8inx 6757 19 years year NNS cord-010092-uftc8inx 6757 20 , , , cord-010092-uftc8inx 6757 21 in in IN cord-010092-uftc8inx 6757 22 2016 2016 CD cord-010092-uftc8inx 6757 23 was be VBD cord-010092-uftc8inx 6757 24 5.6 5.6 CD cord-010092-uftc8inx 6757 25 % % NN cord-010092-uftc8inx 6757 26 , , , cord-010092-uftc8inx 6757 27 in in IN cord-010092-uftc8inx 6757 28 2017 2017 CD cord-010092-uftc8inx 6757 29 was be VBD cord-010092-uftc8inx 6757 30 3.8 3.8 CD cord-010092-uftc8inx 6757 31 % % NN cord-010092-uftc8inx 6757 32 and and CC cord-010092-uftc8inx 6757 33 0.2 0.2 CD cord-010092-uftc8inx 6757 34 % % NN cord-010092-uftc8inx 6757 35 in in IN cord-010092-uftc8inx 6757 36 2018 2018 CD cord-010092-uftc8inx 6757 37 . . . cord-010092-uftc8inx 6758 1 Similar similar JJ cord-010092-uftc8inx 6758 2 tendency tendency NN cord-010092-uftc8inx 6758 3 was be VBD cord-010092-uftc8inx 6758 4 shown show VBN cord-010092-uftc8inx 6758 5 in in IN cord-010092-uftc8inx 6758 6 the the DT cord-010092-uftc8inx 6758 7 pooled pooled JJ cord-010092-uftc8inx 6758 8 platelets platelet NNS cord-010092-uftc8inx 6758 9 for for IN cord-010092-uftc8inx 6758 10 2 2 CD cord-010092-uftc8inx 6758 11 consecutive consecutive JJ cord-010092-uftc8inx 6758 12 years year NNS cord-010092-uftc8inx 6758 13 with with IN cord-010092-uftc8inx 6758 14 4.8 4.8 CD cord-010092-uftc8inx 6758 15 % % NN cord-010092-uftc8inx 6758 16 ( ( -LRB- cord-010092-uftc8inx 6758 17 2016 2016 CD cord-010092-uftc8inx 6758 18 ) ) -RRB- cord-010092-uftc8inx 6758 19 and and CC cord-010092-uftc8inx 6758 20 3.8 3.8 CD cord-010092-uftc8inx 6758 21 % % NN cord-010092-uftc8inx 6758 22 ( ( -LRB- cord-010092-uftc8inx 6758 23 2017 2017 CD cord-010092-uftc8inx 6758 24 ) ) -RRB- cord-010092-uftc8inx 6758 25 , , , cord-010092-uftc8inx 6758 26 but but CC cord-010092-uftc8inx 6758 27 with with IN cord-010092-uftc8inx 6758 28 an an DT cord-010092-uftc8inx 6758 29 increase increase NN cord-010092-uftc8inx 6758 30 in in IN cord-010092-uftc8inx 6758 31 2018 2018 CD cord-010092-uftc8inx 6758 32 ( ( -LRB- cord-010092-uftc8inx 6758 33 7.7 7.7 CD cord-010092-uftc8inx 6758 34 % % NN cord-010092-uftc8inx 6758 35 ) ) -RRB- cord-010092-uftc8inx 6758 36 . . . cord-010092-uftc8inx 6759 1 The the DT cord-010092-uftc8inx 6759 2 rate rate NN cord-010092-uftc8inx 6759 3 of of IN cord-010092-uftc8inx 6759 4 apheresis apheresis NN cord-010092-uftc8inx 6759 5 platelets platelet NNS cord-010092-uftc8inx 6759 6 had have VBD cord-010092-uftc8inx 6759 7 a a DT cord-010092-uftc8inx 6759 8 more more RBR cord-010092-uftc8inx 6759 9 variable variable JJ cord-010092-uftc8inx 6759 10 behaviour behaviour NN cord-010092-uftc8inx 6759 11 from from IN cord-010092-uftc8inx 6759 12 2016 2016 CD cord-010092-uftc8inx 6759 13 to to IN cord-010092-uftc8inx 6759 14 2018 2018 CD cord-010092-uftc8inx 6759 15 with with IN cord-010092-uftc8inx 6759 16 rates rate NNS cord-010092-uftc8inx 6759 17 of of IN cord-010092-uftc8inx 6759 18 1.3 1.3 CD cord-010092-uftc8inx 6759 19 % % NN cord-010092-uftc8inx 6759 20 , , , cord-010092-uftc8inx 6759 21 0.6 0.6 CD cord-010092-uftc8inx 6759 22 % % NN cord-010092-uftc8inx 6759 23 , , , cord-010092-uftc8inx 6759 24 and and CC cord-010092-uftc8inx 6759 25 0.9 0.9 CD cord-010092-uftc8inx 6759 26 % % NN cord-010092-uftc8inx 6759 27 respectively respectively RB cord-010092-uftc8inx 6759 28 . . . cord-010092-uftc8inx 6760 1 Summary Summary NNP cord-010092-uftc8inx 6760 2 / / SYM cord-010092-uftc8inx 6760 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 6760 4 : : : cord-010092-uftc8inx 6761 1 Blood blood NN cord-010092-uftc8inx 6761 2 transfusion transfusion NN cord-010092-uftc8inx 6761 3 is be VBZ cord-010092-uftc8inx 6761 4 an an DT cord-010092-uftc8inx 6761 5 essential essential JJ cord-010092-uftc8inx 6761 6 part part NN cord-010092-uftc8inx 6761 7 of of IN cord-010092-uftc8inx 6761 8 patient patient JJ cord-010092-uftc8inx 6761 9 care care NN cord-010092-uftc8inx 6761 10 . . . cord-010092-uftc8inx 6762 1 For for IN cord-010092-uftc8inx 6762 2 this this DT cord-010092-uftc8inx 6762 3 reason reason NN cord-010092-uftc8inx 6762 4 , , , cord-010092-uftc8inx 6762 5 the the DT cord-010092-uftc8inx 6762 6 implementation implementation NN cord-010092-uftc8inx 6762 7 of of IN cord-010092-uftc8inx 6762 8 a a DT cord-010092-uftc8inx 6762 9 quality quality NN cord-010092-uftc8inx 6762 10 system system NN cord-010092-uftc8inx 6762 11 and and CC cord-010092-uftc8inx 6762 12 continuous continuous JJ cord-010092-uftc8inx 6762 13 evaluation evaluation NN cord-010092-uftc8inx 6762 14 of of IN cord-010092-uftc8inx 6762 15 all all DT cord-010092-uftc8inx 6762 16 activities activity NNS cord-010092-uftc8inx 6762 17 of of IN cord-010092-uftc8inx 6762 18 the the DT cord-010092-uftc8inx 6762 19 BB bb NN cord-010092-uftc8inx 6762 20 can can MD cord-010092-uftc8inx 6762 21 help help VB cord-010092-uftc8inx 6762 22 to to TO cord-010092-uftc8inx 6762 23 achieve achieve VB cord-010092-uftc8inx 6762 24 maximum maximum JJ cord-010092-uftc8inx 6762 25 quantity quantity NN cord-010092-uftc8inx 6762 26 and and CC cord-010092-uftc8inx 6762 27 quality quality NN cord-010092-uftc8inx 6762 28 of of IN cord-010092-uftc8inx 6762 29 safe safe JJ cord-010092-uftc8inx 6762 30 blood blood NN cord-010092-uftc8inx 6762 31 . . . cord-010092-uftc8inx 6763 1 We -PRON- PRP cord-010092-uftc8inx 6763 2 identified identify VBD cord-010092-uftc8inx 6763 3 that that DT cord-010092-uftc8inx 6763 4 date date NN cord-010092-uftc8inx 6763 5 expiry expiry NN cord-010092-uftc8inx 6763 6 was be VBD cord-010092-uftc8inx 6763 7 the the DT cord-010092-uftc8inx 6763 8 main main JJ cord-010092-uftc8inx 6763 9 reason reason NN cord-010092-uftc8inx 6763 10 of of IN cord-010092-uftc8inx 6763 11 discarded discard VBN cord-010092-uftc8inx 6763 12 blood blood NN cord-010092-uftc8inx 6763 13 components component NNS cord-010092-uftc8inx 6763 14 , , , cord-010092-uftc8inx 6763 15 although although IN cord-010092-uftc8inx 6763 16 there there EX cord-010092-uftc8inx 6763 17 was be VBD cord-010092-uftc8inx 6763 18 a a DT cord-010092-uftc8inx 6763 19 significant significant JJ cord-010092-uftc8inx 6763 20 decrease decrease NN cord-010092-uftc8inx 6763 21 in in IN cord-010092-uftc8inx 6763 22 the the DT cord-010092-uftc8inx 6763 23 rate rate NN cord-010092-uftc8inx 6763 24 of of IN cord-010092-uftc8inx 6763 25 discarded discard VBN cord-010092-uftc8inx 6763 26 packed pack VBN cord-010092-uftc8inx 6763 27 red red JJ cord-010092-uftc8inx 6763 28 cells cell NNS cord-010092-uftc8inx 6763 29 over over IN cord-010092-uftc8inx 6763 30 these these DT cord-010092-uftc8inx 6763 31 three three CD cord-010092-uftc8inx 6763 32 years year NNS cord-010092-uftc8inx 6763 33 . . . cord-010092-uftc8inx 6764 1 Properly properly RB cord-010092-uftc8inx 6764 2 implemented implement VBN cord-010092-uftc8inx 6764 3 blood blood NN cord-010092-uftc8inx 6764 4 transfusion transfusion NN cord-010092-uftc8inx 6764 5 policies policy NNS cord-010092-uftc8inx 6764 6 , , , cord-010092-uftc8inx 6764 7 donor donor NN cord-010092-uftc8inx 6764 8 screening screening NN cord-010092-uftc8inx 6764 9 and and CC cord-010092-uftc8inx 6764 10 training training NN cord-010092-uftc8inx 6764 11 staff staff NN cord-010092-uftc8inx 6764 12 as as RB cord-010092-uftc8inx 6764 13 well well RB cord-010092-uftc8inx 6764 14 as as IN cord-010092-uftc8inx 6764 15 implementation implementation NN cord-010092-uftc8inx 6764 16 of of IN cord-010092-uftc8inx 6764 17 automation automation NN cord-010092-uftc8inx 6764 18 also also RB cord-010092-uftc8inx 6764 19 helps help VBZ cord-010092-uftc8inx 6764 20 to to TO cord-010092-uftc8inx 6764 21 improve improve VB cord-010092-uftc8inx 6764 22 the the DT cord-010092-uftc8inx 6764 23 process process NN cord-010092-uftc8inx 6764 24 , , , cord-010092-uftc8inx 6764 25 reducing reduce VBG cord-010092-uftc8inx 6764 26 the the DT cord-010092-uftc8inx 6764 27 discarding discard VBG cord-010092-uftc8inx 6764 28 rates rate NNS cord-010092-uftc8inx 6764 29 of of IN cord-010092-uftc8inx 6764 30 blood blood NN cord-010092-uftc8inx 6764 31 and and CC cord-010092-uftc8inx 6764 32 blood blood NN cord-010092-uftc8inx 6764 33 component component NN cord-010092-uftc8inx 6764 34 . . . cord-010092-uftc8inx 6765 1 Background background NN cord-010092-uftc8inx 6765 2 : : : cord-010092-uftc8inx 6766 1 Storage storage NN cord-010092-uftc8inx 6766 2 performance performance NN cord-010092-uftc8inx 6766 3 of of IN cord-010092-uftc8inx 6766 4 platelets platelet NNS cord-010092-uftc8inx 6766 5 ( ( -LRB- cord-010092-uftc8inx 6766 6 PLT PLT NNP cord-010092-uftc8inx 6766 7 ) ) -RRB- cord-010092-uftc8inx 6766 8 is be VBZ cord-010092-uftc8inx 6766 9 associated associate VBN cord-010092-uftc8inx 6766 10 with with IN cord-010092-uftc8inx 6766 11 age age NN cord-010092-uftc8inx 6766 12 of of IN cord-010092-uftc8inx 6766 13 the the DT cord-010092-uftc8inx 6766 14 donor donor NN cord-010092-uftc8inx 6766 15 . . . cord-010092-uftc8inx 6767 1 The the DT cord-010092-uftc8inx 6767 2 risk risk NN cord-010092-uftc8inx 6767 3 for for IN cord-010092-uftc8inx 6767 4 PLT PLT NNP cord-010092-uftc8inx 6767 5 with with IN cord-010092-uftc8inx 6767 6 poor poor JJ cord-010092-uftc8inx 6767 7 storage storage NN cord-010092-uftc8inx 6767 8 performance performance NN cord-010092-uftc8inx 6767 9 , , , cord-010092-uftc8inx 6767 10 characterized characterize VBN cord-010092-uftc8inx 6767 11 by by IN cord-010092-uftc8inx 6767 12 high high JJ cord-010092-uftc8inx 6767 13 lactate lactate NN cord-010092-uftc8inx 6767 14 production production NN cord-010092-uftc8inx 6767 15 and and CC cord-010092-uftc8inx 6767 16 rapid rapid JJ cord-010092-uftc8inx 6767 17 acidification acidification NN cord-010092-uftc8inx 6767 18 of of IN cord-010092-uftc8inx 6767 19 a a DT cord-010092-uftc8inx 6767 20 PLT PLT NNP cord-010092-uftc8inx 6767 21 concentrate concentrate NN cord-010092-uftc8inx 6767 22 ( ( -LRB- cord-010092-uftc8inx 6767 23 PC pc NN cord-010092-uftc8inx 6767 24 ) ) -RRB- cord-010092-uftc8inx 6767 25 , , , cord-010092-uftc8inx 6767 26 shows show VBZ cord-010092-uftc8inx 6767 27 a a DT cord-010092-uftc8inx 6767 28 positive positive JJ cord-010092-uftc8inx 6767 29 correlation correlation NN cord-010092-uftc8inx 6767 30 with with IN cord-010092-uftc8inx 6767 31 age age NN cord-010092-uftc8inx 6767 32 . . . cord-010092-uftc8inx 6768 1 We -PRON- PRP cord-010092-uftc8inx 6768 2 wished wish VBD cord-010092-uftc8inx 6768 3 to to TO cord-010092-uftc8inx 6768 4 explore explore VB cord-010092-uftc8inx 6768 5 whether whether IN cord-010092-uftc8inx 6768 6 high high JJ cord-010092-uftc8inx 6768 7 lactate lactate NN cord-010092-uftc8inx 6768 8 production production NN cord-010092-uftc8inx 6768 9 was be VBD cord-010092-uftc8inx 6768 10 associated associate VBN cord-010092-uftc8inx 6768 11 with with IN cord-010092-uftc8inx 6768 12 donor donor NN cord-010092-uftc8inx 6768 13 health health NN cord-010092-uftc8inx 6768 14 issues issue NNS cord-010092-uftc8inx 6768 15 . . . cord-010092-uftc8inx 6769 1 Aims aim VBZ cord-010092-uftc8inx 6769 2 : : : cord-010092-uftc8inx 6769 3 To to TO cord-010092-uftc8inx 6769 4 investigate investigate VB cord-010092-uftc8inx 6769 5 high high JJ cord-010092-uftc8inx 6769 6 lactate lactate NN cord-010092-uftc8inx 6769 7 production production NN cord-010092-uftc8inx 6769 8 by by IN cord-010092-uftc8inx 6769 9 stored store VBN cord-010092-uftc8inx 6769 10 platelets platelet NNS cord-010092-uftc8inx 6769 11 in in IN cord-010092-uftc8inx 6769 12 relationship relationship NN cord-010092-uftc8inx 6769 13 to to IN cord-010092-uftc8inx 6769 14 donor donor NN cord-010092-uftc8inx 6769 15 health health NN cord-010092-uftc8inx 6769 16 . . . cord-010092-uftc8inx 6770 1 Methods method NNS cord-010092-uftc8inx 6770 2 : : : cord-010092-uftc8inx 6770 3 Single single JJ cord-010092-uftc8inx 6770 4 - - HYPH cord-010092-uftc8inx 6770 5 donor donor NN cord-010092-uftc8inx 6770 6 PC pc NN cord-010092-uftc8inx 6770 7 were be VBD cord-010092-uftc8inx 6770 8 collected collect VBN cord-010092-uftc8inx 6770 9 by by IN cord-010092-uftc8inx 6770 10 apheresis apheresis NN cord-010092-uftc8inx 6770 11 or or CC cord-010092-uftc8inx 6770 12 prepared prepare VBN cord-010092-uftc8inx 6770 13 from from IN cord-010092-uftc8inx 6770 14 1 1 CD cord-010092-uftc8inx 6770 15 buffy buffy NNP cord-010092-uftc8inx 6770 16 coat coat NN cord-010092-uftc8inx 6770 17 and and CC cord-010092-uftc8inx 6770 18 donors donor NNS cord-010092-uftc8inx 6770 19 were be VBD cord-010092-uftc8inx 6770 20 evaluated evaluate VBN cord-010092-uftc8inx 6770 21 who who WP cord-010092-uftc8inx 6770 22 could could MD cord-010092-uftc8inx 6770 23 be be VB cord-010092-uftc8inx 6770 24 marked mark VBN cord-010092-uftc8inx 6770 25 as as IN cord-010092-uftc8inx 6770 26 ' ' `` cord-010092-uftc8inx 6770 27 rapid rapid JJ cord-010092-uftc8inx 6770 28 acidifiers acidifier NNS cord-010092-uftc8inx 6770 29 ' ' '' cord-010092-uftc8inx 6770 30 . . . cord-010092-uftc8inx 6771 1 In in IN cord-010092-uftc8inx 6771 2 total total JJ cord-010092-uftc8inx 6771 3 , , , cord-010092-uftc8inx 6771 4 31 31 CD cord-010092-uftc8inx 6771 5 apheresis apheresis NN cord-010092-uftc8inx 6771 6 PCs pc NNS cord-010092-uftc8inx 6771 7 and and CC cord-010092-uftc8inx 6771 8 66 66 CD cord-010092-uftc8inx 6771 9 PCs pc NNS cord-010092-uftc8inx 6771 10 from from IN cord-010092-uftc8inx 6771 11 whole whole JJ cord-010092-uftc8inx 6771 12 blood blood NN cord-010092-uftc8inx 6771 13 were be VBD cord-010092-uftc8inx 6771 14 included include VBN cord-010092-uftc8inx 6771 15 in in IN cord-010092-uftc8inx 6771 16 four four CD cord-010092-uftc8inx 6771 17 studies study NNS cord-010092-uftc8inx 6771 18 . . . cord-010092-uftc8inx 6772 1 Information information NN cord-010092-uftc8inx 6772 2 about about IN cord-010092-uftc8inx 6772 3 donor donor NN cord-010092-uftc8inx 6772 4 health health NN cord-010092-uftc8inx 6772 5 was be VBD cord-010092-uftc8inx 6772 6 obtained obtain VBN cord-010092-uftc8inx 6772 7 either either CC cord-010092-uftc8inx 6772 8 from from IN cord-010092-uftc8inx 6772 9 the the DT cord-010092-uftc8inx 6772 10 blood blood NN cord-010092-uftc8inx 6772 11 bank bank NN cord-010092-uftc8inx 6772 12 information information NN cord-010092-uftc8inx 6772 13 system system NN cord-010092-uftc8inx 6772 14 or or CC cord-010092-uftc8inx 6772 15 using use VBG cord-010092-uftc8inx 6772 16 questionnaires questionnaire NNS cord-010092-uftc8inx 6772 17 . . . cord-010092-uftc8inx 6773 1 In in IN cord-010092-uftc8inx 6773 2 some some DT cord-010092-uftc8inx 6773 3 donors donor NNS cord-010092-uftc8inx 6773 4 , , , cord-010092-uftc8inx 6773 5 the the DT cord-010092-uftc8inx 6773 6 lipid lipid NN cord-010092-uftc8inx 6773 7 profile profile NN cord-010092-uftc8inx 6773 8 was be VBD cord-010092-uftc8inx 6773 9 measured measure VBN cord-010092-uftc8inx 6773 10 from from IN cord-010092-uftc8inx 6773 11 plasma plasma NN cord-010092-uftc8inx 6773 12 , , , cord-010092-uftc8inx 6773 13 and and CC cord-010092-uftc8inx 6773 14 the the DT cord-010092-uftc8inx 6773 15 diabetes diabetes NN cord-010092-uftc8inx 6773 16 marker marker NN cord-010092-uftc8inx 6773 17 HbA1c hba1c NN cord-010092-uftc8inx 6773 18 from from IN cord-010092-uftc8inx 6773 19 red red JJ cord-010092-uftc8inx 6773 20 cells cell NNS cord-010092-uftc8inx 6773 21 . . . cord-010092-uftc8inx 6774 1 Triglyceride triglyceride NN cord-010092-uftc8inx 6774 2 levels level NNS cord-010092-uftc8inx 6774 3 > > NFP cord-010092-uftc8inx 6774 4 2.5 2.5 CD cord-010092-uftc8inx 6774 5 mmol mmol JJ cord-010092-uftc8inx 6774 6 / / SYM cord-010092-uftc8inx 6774 7 L l NN cord-010092-uftc8inx 6774 8 and and CC cord-010092-uftc8inx 6774 9 HbA1c HbA1c NNP cord-010092-uftc8inx 6774 10 levels level NNS cord-010092-uftc8inx 6774 11 > > NFP cord-010092-uftc8inx 6774 12 42 42 CD cord-010092-uftc8inx 6774 13 mmol mmol JJ cord-010092-uftc8inx 6774 14 / / SYM cord-010092-uftc8inx 6774 15 mol mol NN cord-010092-uftc8inx 6774 16 were be VBD cord-010092-uftc8inx 6774 17 defined define VBN cord-010092-uftc8inx 6774 18 as as IN cord-010092-uftc8inx 6774 19 high high JJ cord-010092-uftc8inx 6774 20 . . . cord-010092-uftc8inx 6775 1 Results result NNS cord-010092-uftc8inx 6775 2 : : : cord-010092-uftc8inx 6776 1 Twenty twenty CD cord-010092-uftc8inx 6776 2 two two CD cord-010092-uftc8inx 6776 3 percent percent NN cord-010092-uftc8inx 6776 4 ( ( -LRB- cord-010092-uftc8inx 6776 5 21/97 21/97 CD cord-010092-uftc8inx 6776 6 ) ) -RRB- cord-010092-uftc8inx 6776 7 of of IN cord-010092-uftc8inx 6776 8 the the DT cord-010092-uftc8inx 6776 9 donors donor NNS cord-010092-uftc8inx 6776 10 were be VBD cord-010092-uftc8inx 6776 11 marked mark VBN cord-010092-uftc8inx 6776 12 as as IN cord-010092-uftc8inx 6776 13 ' ' `` cord-010092-uftc8inx 6776 14 rapid rapid JJ cord-010092-uftc8inx 6776 15 acidifiers acidifier NNS cord-010092-uftc8inx 6776 16 ' ' POS cord-010092-uftc8inx 6776 17 and and CC cord-010092-uftc8inx 6776 18 71 71 CD cord-010092-uftc8inx 6776 19 % % NN cord-010092-uftc8inx 6776 20 ( ( -LRB- cord-010092-uftc8inx 6776 21 15/21 15/21 CD cord-010092-uftc8inx 6776 22 ) ) -RRB- cord-010092-uftc8inx 6776 23 of of IN cord-010092-uftc8inx 6776 24 these these DT cord-010092-uftc8inx 6776 25 donors donor NNS cord-010092-uftc8inx 6776 26 had have VBD cord-010092-uftc8inx 6776 27 health health NN cord-010092-uftc8inx 6776 28 issues issue NNS cord-010092-uftc8inx 6776 29 . . . cord-010092-uftc8inx 6776 30 ' ' '' cord-010092-uftc8inx 6777 1 Rapid Rapid NNP cord-010092-uftc8inx 6777 2 acidifiers acidifier NNS cord-010092-uftc8inx 6777 3 ' ' '' cord-010092-uftc8inx 6777 4 were be VBD cord-010092-uftc8inx 6777 5 of of IN cord-010092-uftc8inx 6777 6 age age NN cord-010092-uftc8inx 6777 7 57 57 CD cord-010092-uftc8inx 6777 8 , , , cord-010092-uftc8inx 6777 9 31 31 CD cord-010092-uftc8inx 6777 10 - - SYM cord-010092-uftc8inx 6777 11 69 69 CD cord-010092-uftc8inx 6777 12 ( ( -LRB- cord-010092-uftc8inx 6777 13 median median NN cord-010092-uftc8inx 6777 14 , , , cord-010092-uftc8inx 6777 15 range range NN cord-010092-uftc8inx 6777 16 ) ) -RRB- cord-010092-uftc8inx 6777 17 years year NNS cord-010092-uftc8inx 6777 18 . . . cord-010092-uftc8inx 6778 1 Three three CD cord-010092-uftc8inx 6778 2 groups group NNS cord-010092-uftc8inx 6778 3 of of IN cord-010092-uftc8inx 6778 4 donors donor NNS cord-010092-uftc8inx 6778 5 can can MD cord-010092-uftc8inx 6778 6 be be VB cord-010092-uftc8inx 6778 7 distinguished distinguish VBN cord-010092-uftc8inx 6778 8 : : : cord-010092-uftc8inx 6778 9 a a LS cord-010092-uftc8inx 6778 10 ) ) -RRB- cord-010092-uftc8inx 6778 11 Donors donor NNS cord-010092-uftc8inx 6778 12 affected affect VBN cord-010092-uftc8inx 6778 13 by by IN cord-010092-uftc8inx 6778 14 metabolic metabolic JJ cord-010092-uftc8inx 6778 15 syndrome syndrome NN cord-010092-uftc8inx 6778 16 , , , cord-010092-uftc8inx 6778 17 prediabetes prediabete NNS cord-010092-uftc8inx 6778 18 and and CC cord-010092-uftc8inx 6778 19 Type type NN cord-010092-uftc8inx 6778 20 2 2 CD cord-010092-uftc8inx 6778 21 diabetes diabete NNS cord-010092-uftc8inx 6778 22 , , , cord-010092-uftc8inx 6778 23 indicated indicate VBN cord-010092-uftc8inx 6778 24 by by IN cord-010092-uftc8inx 6778 25 high high JJ cord-010092-uftc8inx 6778 26 cholesterol cholesterol NN cord-010092-uftc8inx 6778 27 and/or and/or CC cord-010092-uftc8inx 6778 28 triglycerides triglyceride NNS cord-010092-uftc8inx 6778 29 , , , cord-010092-uftc8inx 6778 30 high high JJ cord-010092-uftc8inx 6778 31 HbA1c hba1c NN cord-010092-uftc8inx 6778 32 and/or and/or CC cord-010092-uftc8inx 6778 33 the the DT cord-010092-uftc8inx 6778 34 use use NN cord-010092-uftc8inx 6778 35 of of IN cord-010092-uftc8inx 6778 36 medication medication NN cord-010092-uftc8inx 6778 37 to to TO cord-010092-uftc8inx 6778 38 treat treat VB cord-010092-uftc8inx 6778 39 diabetes diabete NNS cord-010092-uftc8inx 6778 40 . . . cord-010092-uftc8inx 6779 1 b b LS cord-010092-uftc8inx 6779 2 ) ) -RRB- cord-010092-uftc8inx 6779 3 Donors donor NNS cord-010092-uftc8inx 6779 4 affected affect VBN cord-010092-uftc8inx 6779 5 by by IN cord-010092-uftc8inx 6779 6 vascular vascular JJ cord-010092-uftc8inx 6779 7 diseases disease NNS cord-010092-uftc8inx 6779 8 who who WP cord-010092-uftc8inx 6779 9 reported report VBD cord-010092-uftc8inx 6779 10 or or CC cord-010092-uftc8inx 6779 11 used use VBD cord-010092-uftc8inx 6779 12 medication medication NN cord-010092-uftc8inx 6779 13 to to TO cord-010092-uftc8inx 6779 14 treat treat VB cord-010092-uftc8inx 6779 15 high high JJ cord-010092-uftc8inx 6779 16 blood blood NN cord-010092-uftc8inx 6779 17 pressure pressure NN cord-010092-uftc8inx 6779 18 . . . cord-010092-uftc8inx 6780 1 c c LS cord-010092-uftc8inx 6780 2 ) ) -RRB- cord-010092-uftc8inx 6780 3 " " `` cord-010092-uftc8inx 6780 4 Other other JJ cord-010092-uftc8inx 6780 5 " " '' cord-010092-uftc8inx 6780 6 donors donor NNS cord-010092-uftc8inx 6780 7 who who WP cord-010092-uftc8inx 6780 8 used use VBD cord-010092-uftc8inx 6780 9 other other JJ cord-010092-uftc8inx 6780 10 medication medication NN cord-010092-uftc8inx 6780 11 to to TO cord-010092-uftc8inx 6780 12 treat treat VB cord-010092-uftc8inx 6780 13 various various JJ cord-010092-uftc8inx 6780 14 other other JJ cord-010092-uftc8inx 6780 15 conditions condition NNS cord-010092-uftc8inx 6780 16 . . . cord-010092-uftc8inx 6781 1 The the DT cord-010092-uftc8inx 6781 2 remaining remain VBG cord-010092-uftc8inx 6781 3 ' ' `` cord-010092-uftc8inx 6781 4 rapid rapid JJ cord-010092-uftc8inx 6781 5 acidifiers acidifier NNS cord-010092-uftc8inx 6781 6 ' ' '' cord-010092-uftc8inx 6781 7 ( ( -LRB- cord-010092-uftc8inx 6781 8 29 29 CD cord-010092-uftc8inx 6781 9 % % NN cord-010092-uftc8inx 6781 10 ) ) -RRB- cord-010092-uftc8inx 6781 11 did do VBD cord-010092-uftc8inx 6781 12 not not RB cord-010092-uftc8inx 6781 13 have have VB cord-010092-uftc8inx 6781 14 high high JJ cord-010092-uftc8inx 6781 15 triglyceride triglyceride NN cord-010092-uftc8inx 6781 16 or or CC cord-010092-uftc8inx 6781 17 HbA1c hba1c NN cord-010092-uftc8inx 6781 18 levels level NNS cord-010092-uftc8inx 6781 19 and and CC cord-010092-uftc8inx 6781 20 did do VBD cord-010092-uftc8inx 6781 21 not not RB cord-010092-uftc8inx 6781 22 report report VB cord-010092-uftc8inx 6781 23 health health NN cord-010092-uftc8inx 6781 24 issues issue NNS cord-010092-uftc8inx 6781 25 . . . cord-010092-uftc8inx 6782 1 Summary Summary NNP cord-010092-uftc8inx 6782 2 / / SYM cord-010092-uftc8inx 6782 3 Conclusions conclusion NNS cord-010092-uftc8inx 6782 4 : : : cord-010092-uftc8inx 6782 5 PCs pc NNS cord-010092-uftc8inx 6782 6 with with IN cord-010092-uftc8inx 6782 7 rapid rapid JJ cord-010092-uftc8inx 6782 8 acidification acidification NN cord-010092-uftc8inx 6782 9 by by IN cord-010092-uftc8inx 6782 10 high high JJ cord-010092-uftc8inx 6782 11 lactate lactate NN cord-010092-uftc8inx 6782 12 production production NN cord-010092-uftc8inx 6782 13 are be VBP cord-010092-uftc8inx 6782 14 mainly mainly RB cord-010092-uftc8inx 6782 15 collected collect VBN cord-010092-uftc8inx 6782 16 from from IN cord-010092-uftc8inx 6782 17 older old JJR cord-010092-uftc8inx 6782 18 donors donor NNS cord-010092-uftc8inx 6782 19 with with IN cord-010092-uftc8inx 6782 20 health health NN cord-010092-uftc8inx 6782 21 issues issue NNS cord-010092-uftc8inx 6782 22 . . . cord-010092-uftc8inx 6783 1 We -PRON- PRP cord-010092-uftc8inx 6783 2 postulate postulate VBP cord-010092-uftc8inx 6783 3 that that IN cord-010092-uftc8inx 6783 4 high high JJ cord-010092-uftc8inx 6783 5 lactate lactate NN cord-010092-uftc8inx 6783 6 production production NN cord-010092-uftc8inx 6783 7 by by IN cord-010092-uftc8inx 6783 8 stored store VBN cord-010092-uftc8inx 6783 9 PLTs plt NNS cord-010092-uftc8inx 6783 10 is be VBZ cord-010092-uftc8inx 6783 11 associated associate VBN cord-010092-uftc8inx 6783 12 with with IN cord-010092-uftc8inx 6783 13 health health NN cord-010092-uftc8inx 6783 14 issues issue NNS cord-010092-uftc8inx 6783 15 , , , cord-010092-uftc8inx 6783 16 and and CC cord-010092-uftc8inx 6783 17 we -PRON- PRP cord-010092-uftc8inx 6783 18 will will MD cord-010092-uftc8inx 6783 19 combine combine VB cord-010092-uftc8inx 6783 20 detailed detailed JJ cord-010092-uftc8inx 6783 21 donor donor NN cord-010092-uftc8inx 6783 22 information information NN cord-010092-uftc8inx 6783 23 ( ( -LRB- cord-010092-uftc8inx 6783 24 health health NN cord-010092-uftc8inx 6783 25 and and CC cord-010092-uftc8inx 6783 26 behavior behavior NN cord-010092-uftc8inx 6783 27 ) ) -RRB- cord-010092-uftc8inx 6783 28 with with IN cord-010092-uftc8inx 6783 29 in in FW cord-010092-uftc8inx 6783 30 vitro vitro FW cord-010092-uftc8inx 6783 31 quality quality NN cord-010092-uftc8inx 6783 32 for for IN cord-010092-uftc8inx 6783 33 a a DT cord-010092-uftc8inx 6783 34 significant significant JJ cord-010092-uftc8inx 6783 35 number number NN cord-010092-uftc8inx 6783 36 of of IN cord-010092-uftc8inx 6783 37 donations donation NNS cord-010092-uftc8inx 6783 38 . . . cord-010092-uftc8inx 6784 1 Background background NN cord-010092-uftc8inx 6784 2 : : : cord-010092-uftc8inx 6785 1 The the DT cord-010092-uftc8inx 6785 2 development development NN cord-010092-uftc8inx 6785 3 of of IN cord-010092-uftc8inx 6785 4 applied apply VBN cord-010092-uftc8inx 6785 5 biotechnologies biotechnology NNS cord-010092-uftc8inx 6785 6 requires require VBZ cord-010092-uftc8inx 6785 7 a a DT cord-010092-uftc8inx 6785 8 search search NN cord-010092-uftc8inx 6785 9 and and CC cord-010092-uftc8inx 6785 10 creation creation NN cord-010092-uftc8inx 6785 11 of of IN cord-010092-uftc8inx 6785 12 new new JJ cord-010092-uftc8inx 6785 13 methods method NNS cord-010092-uftc8inx 6785 14 of of IN cord-010092-uftc8inx 6785 15 cells cell NNS cord-010092-uftc8inx 6785 16 ' ' POS cord-010092-uftc8inx 6785 17 functional functional JJ cord-010092-uftc8inx 6785 18 completeness completeness NN cord-010092-uftc8inx 6785 19 analysis analysis NN cord-010092-uftc8inx 6785 20 . . . cord-010092-uftc8inx 6786 1 The the DT cord-010092-uftc8inx 6786 2 instrumental instrumental JJ cord-010092-uftc8inx 6786 3 assessment assessment NN cord-010092-uftc8inx 6786 4 of of IN cord-010092-uftc8inx 6786 5 platelets platelet NNS cord-010092-uftc8inx 6786 6 quality quality NN cord-010092-uftc8inx 6786 7 for for IN cord-010092-uftc8inx 6786 8 the the DT cord-010092-uftc8inx 6786 9 selection selection NN cord-010092-uftc8inx 6786 10 of of IN cord-010092-uftc8inx 6786 11 the the DT cord-010092-uftc8inx 6786 12 most most RBS cord-010092-uftc8inx 6786 13 effective effective JJ cord-010092-uftc8inx 6786 14 donors donor NNS cord-010092-uftc8inx 6786 15 , , , cord-010092-uftc8inx 6786 16 quality quality NN cord-010092-uftc8inx 6786 17 assessment assessment NN cord-010092-uftc8inx 6786 18 of of IN cord-010092-uftc8inx 6786 19 platelet platelet NN cord-010092-uftc8inx 6786 20 concentrates concentrate VBZ cord-010092-uftc8inx 6786 21 for for IN cord-010092-uftc8inx 6786 22 short short JJ cord-010092-uftc8inx 6786 23 and and CC cord-010092-uftc8inx 6786 24 long long JJ cord-010092-uftc8inx 6786 25 - - HYPH cord-010092-uftc8inx 6786 26 term term NN cord-010092-uftc8inx 6786 27 storage storage NN cord-010092-uftc8inx 6786 28 and and CC cord-010092-uftc8inx 6786 29 for for IN cord-010092-uftc8inx 6786 30 the the DT cord-010092-uftc8inx 6786 31 selection selection NN cord-010092-uftc8inx 6786 32 of of IN cord-010092-uftc8inx 6786 33 platelets platelet NNS cord-010092-uftc8inx 6786 34 for for IN cord-010092-uftc8inx 6786 35 cryopreservation cryopreservation NN cord-010092-uftc8inx 6786 36 is be VBZ cord-010092-uftc8inx 6786 37 in in IN cord-010092-uftc8inx 6786 38 demand demand NN cord-010092-uftc8inx 6786 39 in in IN cord-010092-uftc8inx 6786 40 blood blood NN cord-010092-uftc8inx 6786 41 service service NN cord-010092-uftc8inx 6786 42 . . . cord-010092-uftc8inx 6787 1 Assessment assessment NN cord-010092-uftc8inx 6787 2 of of IN cord-010092-uftc8inx 6787 3 platelets platelet NNS cord-010092-uftc8inx 6787 4 morphofunctional morphofunctional JJ cord-010092-uftc8inx 6787 5 status status NN cord-010092-uftc8inx 6787 6 is be VBZ cord-010092-uftc8inx 6787 7 possible possible JJ cord-010092-uftc8inx 6787 8 using use VBG cord-010092-uftc8inx 6787 9 morphological morphological JJ cord-010092-uftc8inx 6787 10 studies study NNS cord-010092-uftc8inx 6787 11 of of IN cord-010092-uftc8inx 6787 12 various various JJ cord-010092-uftc8inx 6787 13 platelet platelet NN cord-010092-uftc8inx 6787 14 granules granule NNS cord-010092-uftc8inx 6787 15 fractions fraction NNS cord-010092-uftc8inx 6787 16 ( ( -LRB- cord-010092-uftc8inx 6787 17 Makarov Makarov NNP cord-010092-uftc8inx 6787 18 , , , cord-010092-uftc8inx 6787 19 Med Med NNP cord-010092-uftc8inx 6787 20 . . . cord-010092-uftc8inx 6788 1 Alfavit Alfavit NNP cord-010092-uftc8inx 6788 2 , , , cord-010092-uftc8inx 6788 3 2012 2012 CD cord-010092-uftc8inx 6788 4 ) ) -RRB- cord-010092-uftc8inx 6788 5 . . . cord-010092-uftc8inx 6789 1 Among among IN cord-010092-uftc8inx 6789 2 the the DT cord-010092-uftc8inx 6789 3 biologically biologically RB cord-010092-uftc8inx 6789 4 complete complete JJ cord-010092-uftc8inx 6789 5 platelets platelet NNS cord-010092-uftc8inx 6789 6 there there EX cord-010092-uftc8inx 6789 7 is be VBZ cord-010092-uftc8inx 6789 8 a a DT cord-010092-uftc8inx 6789 9 special special JJ cord-010092-uftc8inx 6789 10 population population NN cord-010092-uftc8inx 6789 11 of of IN cord-010092-uftc8inx 6789 12 cells cell NNS cord-010092-uftc8inx 6789 13 , , , cord-010092-uftc8inx 6789 14 the the DT cord-010092-uftc8inx 6789 15 so so RB cord-010092-uftc8inx 6789 16 - - HYPH cord-010092-uftc8inx 6789 17 called call VBN cord-010092-uftc8inx 6789 18 granule granule NN cord-010092-uftc8inx 6789 19 - - HYPH cord-010092-uftc8inx 6789 20 rich rich JJ cord-010092-uftc8inx 6789 21 platelets platelet NNS cord-010092-uftc8inx 6789 22 ( ( -LRB- cord-010092-uftc8inx 6789 23 GRP GRP NNP cord-010092-uftc8inx 6789 24 ) ) -RRB- cord-010092-uftc8inx 6789 25 . . . cord-010092-uftc8inx 6790 1 These these DT cord-010092-uftc8inx 6790 2 cells cell NNS cord-010092-uftc8inx 6790 3 contain contain VBP cord-010092-uftc8inx 6790 4 the the DT cord-010092-uftc8inx 6790 5 largest large JJS cord-010092-uftc8inx 6790 6 number number NN cord-010092-uftc8inx 6790 7 of of IN cord-010092-uftc8inx 6790 8 cytoplasmic cytoplasmic JJ cord-010092-uftc8inx 6790 9 granules granule NNS cord-010092-uftc8inx 6790 10 ( ( -LRB- cord-010092-uftc8inx 6790 11 more more JJR cord-010092-uftc8inx 6790 12 than than IN cord-010092-uftc8inx 6790 13 10 10 CD cord-010092-uftc8inx 6790 14 visually visually RB cord-010092-uftc8inx 6790 15 distinct distinct JJ cord-010092-uftc8inx 6790 16 granules granule NNS cord-010092-uftc8inx 6790 17 ) ) -RRB- cord-010092-uftc8inx 6790 18 . . . cord-010092-uftc8inx 6791 1 It -PRON- PRP cord-010092-uftc8inx 6791 2 is be VBZ cord-010092-uftc8inx 6791 3 established establish VBN cord-010092-uftc8inx 6791 4 that that IN cord-010092-uftc8inx 6791 5 GRP GRP NNP cord-010092-uftc8inx 6791 6 have have VBP cord-010092-uftc8inx 6791 7 increased increase VBN cord-010092-uftc8inx 6791 8 viability viability NN cord-010092-uftc8inx 6791 9 and and CC cord-010092-uftc8inx 6791 10 functional functional JJ cord-010092-uftc8inx 6791 11 activity activity NN cord-010092-uftc8inx 6791 12 . . . cord-010092-uftc8inx 6792 1 Earlier early RBR cord-010092-uftc8inx 6792 2 we -PRON- PRP cord-010092-uftc8inx 6792 3 found find VBD cord-010092-uftc8inx 6792 4 a a DT cord-010092-uftc8inx 6792 5 correlation correlation NN cord-010092-uftc8inx 6792 6 between between IN cord-010092-uftc8inx 6792 7 the the DT cord-010092-uftc8inx 6792 8 GRP GRP NNP cord-010092-uftc8inx 6792 9 level level NN cord-010092-uftc8inx 6792 10 in in IN cord-010092-uftc8inx 6792 11 blood blood NN cord-010092-uftc8inx 6792 12 plasma plasma NN cord-010092-uftc8inx 6792 13 and and CC cord-010092-uftc8inx 6792 14 shift shift NN cord-010092-uftc8inx 6792 15 of of IN cord-010092-uftc8inx 6792 16 the the DT cord-010092-uftc8inx 6792 17 redox redox JJ cord-010092-uftc8inx 6792 18 potential potential JJ cord-010092-uftc8inx 6792 19 value value NN cord-010092-uftc8inx 6792 20 in in IN cord-010092-uftc8inx 6792 21 blood blood NN cord-010092-uftc8inx 6792 22 plasma plasma NN cord-010092-uftc8inx 6792 23 after after IN cord-010092-uftc8inx 6792 24 cryodestruction cryodestruction NN cord-010092-uftc8inx 6792 25 of of IN cord-010092-uftc8inx 6792 26 platelets platelet NNS cord-010092-uftc8inx 6792 27 ( ( -LRB- cord-010092-uftc8inx 6792 28 Tsivadze Tsivadze NNP cord-010092-uftc8inx 6792 29 et et FW cord-010092-uftc8inx 6792 30 al al NNP cord-010092-uftc8inx 6792 31 . . NNP cord-010092-uftc8inx 6792 32 , , , cord-010092-uftc8inx 6792 33 Doklady Doklady NNP cord-010092-uftc8inx 6792 34 Physical Physical NNP cord-010092-uftc8inx 6792 35 Chemistry Chemistry NNP cord-010092-uftc8inx 6792 36 , , , cord-010092-uftc8inx 6792 37 2016 2016 CD cord-010092-uftc8inx 6792 38 ) ) -RRB- cord-010092-uftc8inx 6792 39 . . . cord-010092-uftc8inx 6793 1 It -PRON- PRP cord-010092-uftc8inx 6793 2 was be VBD cord-010092-uftc8inx 6793 3 suggested suggest VBN cord-010092-uftc8inx 6793 4 that that IN cord-010092-uftc8inx 6793 5 the the DT cord-010092-uftc8inx 6793 6 shift shift NN cord-010092-uftc8inx 6793 7 of of IN cord-010092-uftc8inx 6793 8 the the DT cord-010092-uftc8inx 6793 9 redox redox NN cord-010092-uftc8inx 6793 10 potential potential NN cord-010092-uftc8inx 6793 11 may may MD cord-010092-uftc8inx 6793 12 be be VB cord-010092-uftc8inx 6793 13 partly partly RB cord-010092-uftc8inx 6793 14 due due JJ cord-010092-uftc8inx 6793 15 to to IN cord-010092-uftc8inx 6793 16 the the DT cord-010092-uftc8inx 6793 17 release release NN cord-010092-uftc8inx 6793 18 of of IN cord-010092-uftc8inx 6793 19 the the DT cord-010092-uftc8inx 6793 20 low low JJ cord-010092-uftc8inx 6793 21 molecular molecular JJ cord-010092-uftc8inx 6793 22 weight weight NN cord-010092-uftc8inx 6793 23 antioxidants antioxidant NNS cord-010092-uftc8inx 6793 24 contained contain VBN cord-010092-uftc8inx 6793 25 in in IN cord-010092-uftc8inx 6793 26 functionally functionally RB cord-010092-uftc8inx 6793 27 complete complete JJ cord-010092-uftc8inx 6793 28 platelets platelet NNS cord-010092-uftc8inx 6793 29 outside outside IN cord-010092-uftc8inx 6793 30 the the DT cord-010092-uftc8inx 6793 31 cell cell NN cord-010092-uftc8inx 6793 32 . . . cord-010092-uftc8inx 6794 1 In in IN cord-010092-uftc8inx 6794 2 turn turn NN cord-010092-uftc8inx 6794 3 , , , cord-010092-uftc8inx 6794 4 the the DT cord-010092-uftc8inx 6794 5 concentration concentration NN cord-010092-uftc8inx 6794 6 of of IN cord-010092-uftc8inx 6794 7 low low JJ cord-010092-uftc8inx 6794 8 molecular molecular JJ cord-010092-uftc8inx 6794 9 weight weight NN cord-010092-uftc8inx 6794 10 antioxidants antioxidant NNS cord-010092-uftc8inx 6794 11 can can MD cord-010092-uftc8inx 6794 12 be be VB cord-010092-uftc8inx 6794 13 estimated estimate VBN cord-010092-uftc8inx 6794 14 using use VBG cord-010092-uftc8inx 6794 15 the the DT cord-010092-uftc8inx 6794 16 cyclic cyclic JJ cord-010092-uftc8inx 6794 17 voltammetry voltammetry NN cord-010092-uftc8inx 6794 18 . . . cord-010092-uftc8inx 6795 1 Aims aim VBZ cord-010092-uftc8inx 6795 2 : : : cord-010092-uftc8inx 6796 1 The the DT cord-010092-uftc8inx 6796 2 aim aim NN cord-010092-uftc8inx 6796 3 of of IN cord-010092-uftc8inx 6796 4 the the DT cord-010092-uftc8inx 6796 5 study study NN cord-010092-uftc8inx 6796 6 was be VBD cord-010092-uftc8inx 6796 7 to to TO cord-010092-uftc8inx 6796 8 estimate estimate VB cord-010092-uftc8inx 6796 9 of of IN cord-010092-uftc8inx 6796 10 cyclic cyclic JJ cord-010092-uftc8inx 6796 11 voltammetry voltammetry NN cord-010092-uftc8inx 6796 12 method method NN cord-010092-uftc8inx 6796 13 possibilities possibility NNS cord-010092-uftc8inx 6796 14 for for IN cord-010092-uftc8inx 6796 15 quality quality NN cord-010092-uftc8inx 6796 16 assessment assessment NN cord-010092-uftc8inx 6796 17 of of IN cord-010092-uftc8inx 6796 18 platelets platelet NNS cord-010092-uftc8inx 6796 19 . . . cord-010092-uftc8inx 6797 1 Methods method NNS cord-010092-uftc8inx 6797 2 : : : cord-010092-uftc8inx 6797 3 The the DT cord-010092-uftc8inx 6797 4 functionality functionality NN cord-010092-uftc8inx 6797 5 of of IN cord-010092-uftc8inx 6797 6 platelets platelet NNS cord-010092-uftc8inx 6797 7 was be VBD cord-010092-uftc8inx 6797 8 examined examine VBN cord-010092-uftc8inx 6797 9 in in IN cord-010092-uftc8inx 6797 10 platelet platelet NN cord-010092-uftc8inx 6797 11 concentrate concentrate NN cord-010092-uftc8inx 6797 12 ( ( -LRB- cord-010092-uftc8inx 6797 13 PC pc NN cord-010092-uftc8inx 6797 14 ) ) -RRB- cord-010092-uftc8inx 6797 15 obtained obtain VBN cord-010092-uftc8inx 6797 16 by by IN cord-010092-uftc8inx 6797 17 apheresis apheresis NN cord-010092-uftc8inx 6797 18 ( ( -LRB- cord-010092-uftc8inx 6797 19 1246.8 1246.8 CD cord-010092-uftc8inx 6797 20 AE AE NNP cord-010092-uftc8inx 6797 21 90.1 90.1 CD cord-010092-uftc8inx 6797 22 / / SYM cord-010092-uftc8inx 6797 23 lL lL NNP cord-010092-uftc8inx 6797 24 ) ) -RRB- cord-010092-uftc8inx 6797 25 . . . cord-010092-uftc8inx 6798 1 Voltammetric voltammetric JJ cord-010092-uftc8inx 6798 2 analysis analysis NN cord-010092-uftc8inx 6798 3 in in IN cord-010092-uftc8inx 6798 4 PC pc NN cord-010092-uftc8inx 6798 5 before before RB cord-010092-uftc8inx 6798 6 and and CC cord-010092-uftc8inx 6798 7 after after IN cord-010092-uftc8inx 6798 8 the the DT cord-010092-uftc8inx 6798 9 platelets platelet NNS cord-010092-uftc8inx 6798 10 cryodestruction cryodestruction NN cord-010092-uftc8inx 6798 11 was be VBD cord-010092-uftc8inx 6798 12 carried carry VBN cord-010092-uftc8inx 6798 13 out out RP cord-010092-uftc8inx 6798 14 on on IN cord-010092-uftc8inx 6798 15 platinum platinum NN cord-010092-uftc8inx 6798 16 electrode electrode NN cord-010092-uftc8inx 6798 17 in in IN cord-010092-uftc8inx 6798 18 the the DT cord-010092-uftc8inx 6798 19 potential potential JJ cord-010092-uftc8inx 6798 20 range range NN cord-010092-uftc8inx 6798 21 from from IN cord-010092-uftc8inx 6798 22 À600 à600 CD cord-010092-uftc8inx 6798 23 mV mv NN cord-010092-uftc8inx 6798 24 to to IN cord-010092-uftc8inx 6798 25 +1100 +1100 NN cord-010092-uftc8inx 6799 1 mV mv NN cord-010092-uftc8inx 6799 2 using use VBG cord-010092-uftc8inx 6799 3 a a DT cord-010092-uftc8inx 6799 4 potentiostat potentiostat JJ cord-010092-uftc8inx 6799 5 IPC IPC NNP cord-010092-uftc8inx 6799 6 Pro Pro NNP cord-010092-uftc8inx 6799 7 L L NNP cord-010092-uftc8inx 6799 8 and and CC cord-010092-uftc8inx 6799 9 saturated saturate VBN cord-010092-uftc8inx 6799 10 Ag Ag NNP cord-010092-uftc8inx 6799 11 / / SYM cord-010092-uftc8inx 6799 12 AgCl AgCl NNP cord-010092-uftc8inx 6799 13 electrode electrode NN cord-010092-uftc8inx 6799 14 as as IN cord-010092-uftc8inx 6799 15 reference reference NN cord-010092-uftc8inx 6799 16 . . . cord-010092-uftc8inx 6800 1 For for IN cord-010092-uftc8inx 6800 2 the the DT cord-010092-uftc8inx 6800 3 morphofunctional morphofunctional JJ cord-010092-uftc8inx 6800 4 analysis analysis NN cord-010092-uftc8inx 6800 5 platelets platelet NNS cord-010092-uftc8inx 6800 6 were be VBD cord-010092-uftc8inx 6800 7 vitally vitally RB cord-010092-uftc8inx 6800 8 stained stain VBN cord-010092-uftc8inx 6800 9 with with IN cord-010092-uftc8inx 6800 10 fluorochrome fluorochrome FW cord-010092-uftc8inx 6800 11 stains stain NNS cord-010092-uftc8inx 6800 12 trypaflavin trypaflavin NNP cord-010092-uftc8inx 6800 13 and and CC cord-010092-uftc8inx 6800 14 acridine acridine NNP cord-010092-uftc8inx 6800 15 orange orange NNP cord-010092-uftc8inx 6800 16 . . . cord-010092-uftc8inx 6801 1 Microscopic microscopic JJ cord-010092-uftc8inx 6801 2 examination examination NN cord-010092-uftc8inx 6801 3 of of IN cord-010092-uftc8inx 6801 4 platelets platelet NNS cord-010092-uftc8inx 6801 5 was be VBD cord-010092-uftc8inx 6801 6 carried carry VBN cord-010092-uftc8inx 6801 7 out out RP cord-010092-uftc8inx 6801 8 using use VBG cord-010092-uftc8inx 6801 9 confocal confocal JJ cord-010092-uftc8inx 6801 10 microscope microscope NN cord-010092-uftc8inx 6801 11 Nikon Nikon NNP cord-010092-uftc8inx 6801 12 Eclipse Eclipse NNP cord-010092-uftc8inx 6801 13 80i 80i '' cord-010092-uftc8inx 6801 14 . . . cord-010092-uftc8inx 6802 1 The the DT cord-010092-uftc8inx 6802 2 following following JJ cord-010092-uftc8inx 6802 3 parameters parameter NNS cord-010092-uftc8inx 6802 4 were be VBD cord-010092-uftc8inx 6802 5 evaluated evaluate VBN cord-010092-uftc8inx 6802 6 : : : cord-010092-uftc8inx 6802 7 concentration concentration NN cord-010092-uftc8inx 6802 8 and and CC cord-010092-uftc8inx 6802 9 percentage percentage NN cord-010092-uftc8inx 6802 10 of of IN cord-010092-uftc8inx 6802 11 platelets platelet NNS cord-010092-uftc8inx 6802 12 with with IN cord-010092-uftc8inx 6802 13 granules granule NNS cord-010092-uftc8inx 6802 14 and and CC cord-010092-uftc8inx 6802 15 concentration concentration NN cord-010092-uftc8inx 6802 16 and and CC cord-010092-uftc8inx 6802 17 percentage percentage NN cord-010092-uftc8inx 6802 18 of of IN cord-010092-uftc8inx 6802 19 GRP GRP NNP cord-010092-uftc8inx 6802 20 . . . cord-010092-uftc8inx 6803 1 Results result NNS cord-010092-uftc8inx 6803 2 : : : cord-010092-uftc8inx 6804 1 Voltammetric Voltammetric NNP cord-010092-uftc8inx 6804 2 studies study NNS cord-010092-uftc8inx 6804 3 in in IN cord-010092-uftc8inx 6804 4 PC pc NN cord-010092-uftc8inx 6804 5 show show VBP cord-010092-uftc8inx 6804 6 that that IN cord-010092-uftc8inx 6804 7 there there EX cord-010092-uftc8inx 6804 8 are be VBP cord-010092-uftc8inx 6804 9 two two CD cord-010092-uftc8inx 6804 10 oxidation oxidation NN cord-010092-uftc8inx 6804 11 peaks peak NNS cord-010092-uftc8inx 6804 12 of of IN cord-010092-uftc8inx 6804 13 low low JJ cord-010092-uftc8inx 6804 14 molecular molecular JJ cord-010092-uftc8inx 6804 15 weight weight NN cord-010092-uftc8inx 6804 16 antioxidants antioxidant NNS cord-010092-uftc8inx 6804 17 on on IN cord-010092-uftc8inx 6804 18 voltammogram voltammogram NNP cord-010092-uftc8inx 6804 19 at at IN cord-010092-uftc8inx 6804 20 potentials potential NNS cord-010092-uftc8inx 6804 21 + + SYM cord-010092-uftc8inx 6804 22 500 500 CD cord-010092-uftc8inx 6804 23 mV mV NNS cord-010092-uftc8inx 6804 24 and and CC cord-010092-uftc8inx 6804 25 + + SYM cord-010092-uftc8inx 6804 26 800 800 CD cord-010092-uftc8inx 6804 27 mV. mV. NNP cord-010092-uftc8inx 6804 28 Analysis Analysis NNP cord-010092-uftc8inx 6804 29 of of IN cord-010092-uftc8inx 6804 30 PC PC NNP cord-010092-uftc8inx 6804 31 before before RB cord-010092-uftc8inx 6804 32 and and CC cord-010092-uftc8inx 6805 1 after after IN cord-010092-uftc8inx 6805 2 the the DT cord-010092-uftc8inx 6805 3 cells cell NNS cord-010092-uftc8inx 6805 4 cryodestruction cryodestruction NN cord-010092-uftc8inx 6805 5 showed show VBD cord-010092-uftc8inx 6805 6 that that IN cord-010092-uftc8inx 6805 7 changes change NNS cord-010092-uftc8inx 6805 8 in in IN cord-010092-uftc8inx 6805 9 the the DT cord-010092-uftc8inx 6805 10 height height NN cord-010092-uftc8inx 6805 11 of of IN cord-010092-uftc8inx 6805 12 oxidation oxidation NN cord-010092-uftc8inx 6805 13 peaks peak NNS cord-010092-uftc8inx 6805 14 occur occur VBP cord-010092-uftc8inx 6805 15 , , , cord-010092-uftc8inx 6805 16 indicating indicate VBG cord-010092-uftc8inx 6805 17 an an DT cord-010092-uftc8inx 6805 18 increase increase NN cord-010092-uftc8inx 6805 19 of of IN cord-010092-uftc8inx 6805 20 antioxidant antioxidant JJ cord-010092-uftc8inx 6805 21 content content NN cord-010092-uftc8inx 6805 22 in in IN cord-010092-uftc8inx 6805 23 blood blood NN cord-010092-uftc8inx 6805 24 plasma plasma NN cord-010092-uftc8inx 6805 25 . . . cord-010092-uftc8inx 6806 1 At at IN cord-010092-uftc8inx 6806 2 the the DT cord-010092-uftc8inx 6806 3 same same JJ cord-010092-uftc8inx 6806 4 time time NN cord-010092-uftc8inx 6806 5 a a DT cord-010092-uftc8inx 6806 6 correlation correlation NN cord-010092-uftc8inx 6806 7 between between IN cord-010092-uftc8inx 6806 8 the the DT cord-010092-uftc8inx 6806 9 changes change NNS cord-010092-uftc8inx 6806 10 in in IN cord-010092-uftc8inx 6806 11 the the DT cord-010092-uftc8inx 6806 12 height height NN cord-010092-uftc8inx 6806 13 of of IN cord-010092-uftc8inx 6806 14 oxidation oxidation NN cord-010092-uftc8inx 6806 15 peaks peak NNS cord-010092-uftc8inx 6806 16 and and CC cord-010092-uftc8inx 6806 17 the the DT cord-010092-uftc8inx 6806 18 GRP GRP NNP cord-010092-uftc8inx 6806 19 content content NN cord-010092-uftc8inx 6806 20 in in IN cord-010092-uftc8inx 6806 21 the the DT cord-010092-uftc8inx 6806 22 sample sample NN cord-010092-uftc8inx 6806 23 was be VBD cord-010092-uftc8inx 6806 24 found find VBN cord-010092-uftc8inx 6806 25 . . . cord-010092-uftc8inx 6807 1 In in IN cord-010092-uftc8inx 6807 2 samples sample NNS cord-010092-uftc8inx 6807 3 with with IN cord-010092-uftc8inx 6807 4 reduced reduce VBN cord-010092-uftc8inx 6807 5 initial initial JJ cord-010092-uftc8inx 6807 6 GRP GRP NNP cord-010092-uftc8inx 6807 7 content content NN cord-010092-uftc8inx 6807 8 ( ( -LRB- cord-010092-uftc8inx 6807 9 less less JJR cord-010092-uftc8inx 6807 10 than than IN cord-010092-uftc8inx 6807 11 10 10 CD cord-010092-uftc8inx 6807 12 % % NN cord-010092-uftc8inx 6807 13 ) ) -RRB- cord-010092-uftc8inx 6807 14 after after IN cord-010092-uftc8inx 6807 15 the the DT cord-010092-uftc8inx 6807 16 cells cell NNS cord-010092-uftc8inx 6807 17 cryodestruction cryodestruction NN cord-010092-uftc8inx 6807 18 significant significant JJ cord-010092-uftc8inx 6807 19 changes change NNS cord-010092-uftc8inx 6807 20 in in IN cord-010092-uftc8inx 6807 21 the the DT cord-010092-uftc8inx 6807 22 height height NN cord-010092-uftc8inx 6807 23 of of IN cord-010092-uftc8inx 6807 24 oxidation oxidation NN cord-010092-uftc8inx 6807 25 peaks peak NNS cord-010092-uftc8inx 6807 26 were be VBD cord-010092-uftc8inx 6807 27 not not RB cord-010092-uftc8inx 6807 28 observed observe VBN cord-010092-uftc8inx 6807 29 , , , cord-010092-uftc8inx 6807 30 regardless regardless RB cord-010092-uftc8inx 6807 31 of of IN cord-010092-uftc8inx 6807 32 the the DT cord-010092-uftc8inx 6807 33 total total JJ cord-010092-uftc8inx 6807 34 number number NN cord-010092-uftc8inx 6807 35 of of IN cord-010092-uftc8inx 6807 36 cells cell NNS cord-010092-uftc8inx 6807 37 in in IN cord-010092-uftc8inx 6807 38 the the DT cord-010092-uftc8inx 6807 39 PC pc NN cord-010092-uftc8inx 6807 40 . . . cord-010092-uftc8inx 6808 1 Summary Summary NNP cord-010092-uftc8inx 6808 2 / / SYM cord-010092-uftc8inx 6808 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 6808 4 : : : cord-010092-uftc8inx 6809 1 In in IN cord-010092-uftc8inx 6809 2 conclusion conclusion NN cord-010092-uftc8inx 6809 3 , , , cord-010092-uftc8inx 6809 4 voltammetric voltammetric NNP cord-010092-uftc8inx 6809 5 analysis analysis NN cord-010092-uftc8inx 6809 6 allows allow VBZ cord-010092-uftc8inx 6809 7 to to TO cord-010092-uftc8inx 6809 8 indirectly indirectly RB cord-010092-uftc8inx 6809 9 estimate estimate VB cord-010092-uftc8inx 6809 10 the the DT cord-010092-uftc8inx 6809 11 population population NN cord-010092-uftc8inx 6809 12 of of IN cord-010092-uftc8inx 6809 13 functionally functionally RB cord-010092-uftc8inx 6809 14 active active JJ cord-010092-uftc8inx 6809 15 platelets platelet NNS cord-010092-uftc8inx 6809 16 that that IN cord-010092-uftc8inx 6809 17 in in IN cord-010092-uftc8inx 6809 18 combination combination NN cord-010092-uftc8inx 6809 19 with with IN cord-010092-uftc8inx 6809 20 other other JJ cord-010092-uftc8inx 6809 21 methods method NNS cord-010092-uftc8inx 6809 22 of of IN cord-010092-uftc8inx 6809 23 analysis analysis NN cord-010092-uftc8inx 6809 24 can can MD cord-010092-uftc8inx 6809 25 serve serve VB cord-010092-uftc8inx 6809 26 to to TO cord-010092-uftc8inx 6809 27 assess assess VB cord-010092-uftc8inx 6809 28 the the DT cord-010092-uftc8inx 6809 29 quality quality NN cord-010092-uftc8inx 6809 30 of of IN cord-010092-uftc8inx 6809 31 platelet platelet NN cord-010092-uftc8inx 6809 32 products product NNS cord-010092-uftc8inx 6809 33 . . . cord-010092-uftc8inx 6810 1 Background background NN cord-010092-uftc8inx 6810 2 : : : cord-010092-uftc8inx 6811 1 Determination determination NN cord-010092-uftc8inx 6811 2 of of IN cord-010092-uftc8inx 6811 3 hemoglobin hemoglobin NN cord-010092-uftc8inx 6811 4 derivatives derivative NNS cord-010092-uftc8inx 6811 5 in in IN cord-010092-uftc8inx 6811 6 blood blood NN cord-010092-uftc8inx 6811 7 is be VBZ cord-010092-uftc8inx 6811 8 one one CD cord-010092-uftc8inx 6811 9 of of IN cord-010092-uftc8inx 6811 10 the the DT cord-010092-uftc8inx 6811 11 most most RBS cord-010092-uftc8inx 6811 12 important important JJ cord-010092-uftc8inx 6811 13 studies study NNS cord-010092-uftc8inx 6811 14 in in IN cord-010092-uftc8inx 6811 15 clinical clinical JJ cord-010092-uftc8inx 6811 16 laboratory laboratory NN cord-010092-uftc8inx 6811 17 diagnostics diagnostic NNS cord-010092-uftc8inx 6811 18 , , , cord-010092-uftc8inx 6811 19 especially especially RB cord-010092-uftc8inx 6811 20 during during IN cord-010092-uftc8inx 6811 21 the the DT cord-010092-uftc8inx 6811 22 storage storage NN cord-010092-uftc8inx 6811 23 of of IN cord-010092-uftc8inx 6811 24 donor donor NN cord-010092-uftc8inx 6811 25 blood blood NN cord-010092-uftc8inx 6811 26 and and CC cord-010092-uftc8inx 6811 27 its -PRON- PRP$ cord-010092-uftc8inx 6811 28 transfusion transfusion NN cord-010092-uftc8inx 6811 29 . . . cord-010092-uftc8inx 6812 1 Concentration concentration NN cord-010092-uftc8inx 6812 2 of of IN cord-010092-uftc8inx 6812 3 hemoglobin hemoglobin NN cord-010092-uftc8inx 6812 4 derivatives derivative NNS cord-010092-uftc8inx 6812 5 can can MD cord-010092-uftc8inx 6812 6 be be VB cord-010092-uftc8inx 6812 7 changed change VBN cord-010092-uftc8inx 6812 8 during during IN cord-010092-uftc8inx 6812 9 redox redox JJ cord-010092-uftc8inx 6812 10 process process NN cord-010092-uftc8inx 6812 11 . . . cord-010092-uftc8inx 6813 1 Aims aim VBZ cord-010092-uftc8inx 6813 2 : : : cord-010092-uftc8inx 6813 3 to to TO cord-010092-uftc8inx 6813 4 show show VB cord-010092-uftc8inx 6813 5 the the DT cord-010092-uftc8inx 6813 6 possibility possibility NN cord-010092-uftc8inx 6813 7 of of IN cord-010092-uftc8inx 6813 8 using use VBG cord-010092-uftc8inx 6813 9 non non JJ cord-010092-uftc8inx 6813 10 - - JJ cord-010092-uftc8inx 6813 11 linear linear JJ cord-010092-uftc8inx 6813 12 Fitting Fitting NNP cord-010092-uftc8inx 6813 13 method method NN cord-010092-uftc8inx 6813 14 to to TO cord-010092-uftc8inx 6813 15 calculate calculate VB cord-010092-uftc8inx 6813 16 concentrations concentration NNS cord-010092-uftc8inx 6813 17 of of IN cord-010092-uftc8inx 6813 18 hemoglobin hemoglobin NN cord-010092-uftc8inx 6813 19 derivatives derivative NNS cord-010092-uftc8inx 6813 20 during during IN cord-010092-uftc8inx 6813 21 reduction reduction NN cord-010092-uftc8inx 6813 22 - - HYPH cord-010092-uftc8inx 6813 23 oxidation oxidation NN cord-010092-uftc8inx 6813 24 processes process NNS cord-010092-uftc8inx 6813 25 . . . cord-010092-uftc8inx 6814 1 Methods method NNS cord-010092-uftc8inx 6814 2 : : : cord-010092-uftc8inx 6814 3 For for IN cord-010092-uftc8inx 6814 4 this this DT cord-010092-uftc8inx 6814 5 we -PRON- PRP cord-010092-uftc8inx 6814 6 performed perform VBD cord-010092-uftc8inx 6814 7 model model JJ cord-010092-uftc8inx 6814 8 biophysical biophysical JJ cord-010092-uftc8inx 6814 9 experiment experiment NN cord-010092-uftc8inx 6814 10 , , , cord-010092-uftc8inx 6814 11 in in IN cord-010092-uftc8inx 6814 12 vitro vitro FW cord-010092-uftc8inx 6814 13 . . . cord-010092-uftc8inx 6815 1 Blood blood NN cord-010092-uftc8inx 6815 2 samples sample NNS cord-010092-uftc8inx 6815 3 were be VBD cord-010092-uftc8inx 6815 4 collected collect VBN cord-010092-uftc8inx 6815 5 into into IN cord-010092-uftc8inx 6815 6 EDTA EDTA NNP cord-010092-uftc8inx 6815 7 microvettes microvette NNS cord-010092-uftc8inx 6815 8 from from IN cord-010092-uftc8inx 6815 9 4 4 CD cord-010092-uftc8inx 6815 10 healthy healthy JJ cord-010092-uftc8inx 6815 11 donors donor NNS cord-010092-uftc8inx 6815 12 ( ( -LRB- cord-010092-uftc8inx 6815 13 Sarstedt Sarstedt NNP cord-010092-uftc8inx 6815 14 AG AG NNP cord-010092-uftc8inx 6815 15 and and CC cord-010092-uftc8inx 6815 16 Co. Co. NNP cord-010092-uftc8inx 6815 17 , , , cord-010092-uftc8inx 6815 18 Germany Germany NNP cord-010092-uftc8inx 6815 19 ) ) -RRB- cord-010092-uftc8inx 6815 20 during during IN cord-010092-uftc8inx 6815 21 prophylactic prophylactic JJ cord-010092-uftc8inx 6815 22 examinations examination NNS cord-010092-uftc8inx 6815 23 . . . cord-010092-uftc8inx 6816 1 All all PDT cord-010092-uftc8inx 6816 2 the the DT cord-010092-uftc8inx 6816 3 donors donor NNS cord-010092-uftc8inx 6816 4 gave give VBD cord-010092-uftc8inx 6816 5 their -PRON- PRP$ cord-010092-uftc8inx 6816 6 consent consent NN cord-010092-uftc8inx 6816 7 to to TO cord-010092-uftc8inx 6816 8 participate participate VB cord-010092-uftc8inx 6816 9 in in IN cord-010092-uftc8inx 6816 10 the the DT cord-010092-uftc8inx 6816 11 study study NN cord-010092-uftc8inx 6816 12 . . . cord-010092-uftc8inx 6817 1 A a DT cord-010092-uftc8inx 6817 2 suspension suspension NN cord-010092-uftc8inx 6817 3 of of IN cord-010092-uftc8inx 6817 4 erythrocytes erythrocyte NNS cord-010092-uftc8inx 6817 5 was be VBD cord-010092-uftc8inx 6817 6 prepared prepare VBN cord-010092-uftc8inx 6817 7 in in IN cord-010092-uftc8inx 6817 8 PBS PBS NNP cord-010092-uftc8inx 6817 9 buffer buffer NN cord-010092-uftc8inx 6817 10 with with IN cord-010092-uftc8inx 6817 11 pH pH NNP cord-010092-uftc8inx 6817 12 7.4 7.4 CD cord-010092-uftc8inx 6817 13 . . . cord-010092-uftc8inx 6818 1 We -PRON- PRP cord-010092-uftc8inx 6818 2 used use VBD cord-010092-uftc8inx 6818 3 ultraviolet ultraviolet NN cord-010092-uftc8inx 6818 4 ( ( -LRB- cord-010092-uftc8inx 6818 5 UV uv NN cord-010092-uftc8inx 6818 6 ) ) -RRB- cord-010092-uftc8inx 6818 7 irradiation irradiation NN cord-010092-uftc8inx 6818 8 of of IN cord-010092-uftc8inx 6818 9 blood blood NN cord-010092-uftc8inx 6818 10 or or CC cord-010092-uftc8inx 6818 11 NaNO NaNO NNP cord-010092-uftc8inx 6818 12 2 2 CD cord-010092-uftc8inx 6818 13 as as IN cord-010092-uftc8inx 6818 14 oxidizing oxidizing JJ cord-010092-uftc8inx 6818 15 agent agent NN cord-010092-uftc8inx 6818 16 . . . cord-010092-uftc8inx 6819 1 The the DT cord-010092-uftc8inx 6819 2 drug drug NN cord-010092-uftc8inx 6819 3 cytoflavin cytoflavin NNP cord-010092-uftc8inx 6819 4 ( ( -LRB- cord-010092-uftc8inx 6819 5 STPF STPF NNP cord-010092-uftc8inx 6819 6 " " `` cord-010092-uftc8inx 6819 7 POLISAN polisan NN cord-010092-uftc8inx 6819 8 " " '' cord-010092-uftc8inx 6819 9 , , , cord-010092-uftc8inx 6819 10 Russian Russian NNP cord-010092-uftc8inx 6819 11 Federation Federation NNP cord-010092-uftc8inx 6819 12 ) ) -RRB- cord-010092-uftc8inx 6819 13 was be VBD cord-010092-uftc8inx 6819 14 used use VBN cord-010092-uftc8inx 6819 15 as as IN cord-010092-uftc8inx 6819 16 an an DT cord-010092-uftc8inx 6819 17 antioxidant antioxidant NN cord-010092-uftc8inx 6819 18 . . . cord-010092-uftc8inx 6820 1 In in IN cord-010092-uftc8inx 6820 2 our -PRON- PRP$ cord-010092-uftc8inx 6820 3 study study NN cord-010092-uftc8inx 6820 4 we -PRON- PRP cord-010092-uftc8inx 6820 5 used use VBD cord-010092-uftc8inx 6820 6 digital digital JJ cord-010092-uftc8inx 6820 7 spectrophotometer spectrophotometer NN cord-010092-uftc8inx 6820 8 ( ( -LRB- cord-010092-uftc8inx 6820 9 Unico Unico NNP cord-010092-uftc8inx 6820 10 2800 2800 CD cord-010092-uftc8inx 6820 11 , , , cord-010092-uftc8inx 6820 12 USA USA NNP cord-010092-uftc8inx 6820 13 ) ) -RRB- cord-010092-uftc8inx 6820 14 to to TO cord-010092-uftc8inx 6820 15 measure measure VB cord-010092-uftc8inx 6820 16 the the DT cord-010092-uftc8inx 6820 17 absorption absorption NN cord-010092-uftc8inx 6820 18 and and CC cord-010092-uftc8inx 6820 19 scattering scattering NN cord-010092-uftc8inx 6820 20 of of IN cord-010092-uftc8inx 6820 21 light light NN cord-010092-uftc8inx 6820 22 ( ( -LRB- cord-010092-uftc8inx 6820 23 0.5 0.5 CD cord-010092-uftc8inx 6820 24 nm nm NN cord-010092-uftc8inx 6820 25 step step NN cord-010092-uftc8inx 6820 26 ) ) -RRB- cord-010092-uftc8inx 6820 27 . . . cord-010092-uftc8inx 6821 1 The the DT cord-010092-uftc8inx 6821 2 method method NN cord-010092-uftc8inx 6821 3 of of IN cord-010092-uftc8inx 6821 4 Nonlinear Nonlinear NNP cord-010092-uftc8inx 6821 5 Fitting Fitting NNP cord-010092-uftc8inx 6821 6 was be VBD cord-010092-uftc8inx 6821 7 used use VBN cord-010092-uftc8inx 6821 8 to to TO cord-010092-uftc8inx 6821 9 find find VB cord-010092-uftc8inx 6821 10 the the DT cord-010092-uftc8inx 6821 11 concentrations concentration NNS cord-010092-uftc8inx 6821 12 of of IN cord-010092-uftc8inx 6821 13 hemoglobin hemoglobin NN cord-010092-uftc8inx 6821 14 derivatives derivative NNS cord-010092-uftc8inx 6821 15 . . . cord-010092-uftc8inx 6822 1 The the DT cord-010092-uftc8inx 6822 2 empirical empirical JJ cord-010092-uftc8inx 6822 3 spectrum spectrum NN cord-010092-uftc8inx 6822 4 D d NN cord-010092-uftc8inx 6822 5 l l NN cord-010092-uftc8inx 6822 6 ( ( -LRB- cord-010092-uftc8inx 6822 7 k k NNP cord-010092-uftc8inx 6822 8 ) ) -RRB- cord-010092-uftc8inx 6822 9 exp exp NN cord-010092-uftc8inx 6822 10 was be VBD cord-010092-uftc8inx 6822 11 approximated approximate VBN cord-010092-uftc8inx 6822 12 by by IN cord-010092-uftc8inx 6822 13 the the DT cord-010092-uftc8inx 6822 14 theoretical theoretical JJ cord-010092-uftc8inx 6822 15 curve curve NN cord-010092-uftc8inx 6822 16 D D NNP cord-010092-uftc8inx 6822 17 l l NN cord-010092-uftc8inx 6822 18 ( ( -LRB- cord-010092-uftc8inx 6822 19 k k NNP cord-010092-uftc8inx 6822 20 l l NNP cord-010092-uftc8inx 6822 21 ) ) -RRB- cord-010092-uftc8inx 6822 22 theor theor NNP cord-010092-uftc8inx 6822 23 , , , cord-010092-uftc8inx 6822 24 which which WDT cord-010092-uftc8inx 6822 25 fits fit VBZ cord-010092-uftc8inx 6822 26 the the DT cord-010092-uftc8inx 6822 27 experimental experimental JJ cord-010092-uftc8inx 6822 28 curve curve NN cord-010092-uftc8inx 6822 29 in in IN cord-010092-uftc8inx 6822 30 the the DT cord-010092-uftc8inx 6822 31 best good JJS cord-010092-uftc8inx 6822 32 way way NN cord-010092-uftc8inx 6822 33 . . . cord-010092-uftc8inx 6823 1 Under under IN cord-010092-uftc8inx 6823 2 approximation approximation NN cord-010092-uftc8inx 6823 3 the the DT cord-010092-uftc8inx 6823 4 light light JJ cord-010092-uftc8inx 6823 5 absorption absorption NN cord-010092-uftc8inx 6823 6 by by IN cord-010092-uftc8inx 6823 7 different different JJ cord-010092-uftc8inx 6823 8 hemoglobin hemoglobin NN cord-010092-uftc8inx 6823 9 derivatives derivative NNS cord-010092-uftc8inx 6823 10 was be VBD cord-010092-uftc8inx 6823 11 considered consider VBN cord-010092-uftc8inx 6823 12 in in IN cord-010092-uftc8inx 6823 13 model model NN cord-010092-uftc8inx 6823 14 . . . cord-010092-uftc8inx 6824 1 Simultaneously simultaneously RB cord-010092-uftc8inx 6824 2 effects effect NNS cord-010092-uftc8inx 6824 3 of of IN cord-010092-uftc8inx 6824 4 Rayleigh Rayleigh NNP cord-010092-uftc8inx 6824 5 light light NN cord-010092-uftc8inx 6824 6 scattering scattering NN cord-010092-uftc8inx 6824 7 on on IN cord-010092-uftc8inx 6824 8 structures structure NNS cord-010092-uftc8inx 6824 9 with with IN cord-010092-uftc8inx 6824 10 size size NN cord-010092-uftc8inx 6824 11 D d NN cord-010092-uftc8inx 6825 1 < < XX cord-010092-uftc8inx 6825 2 < < XX cord-010092-uftc8inx 6826 1 k k NNP cord-010092-uftc8inx 6826 2 ( ( -LRB- cord-010092-uftc8inx 6826 3 coefficient coefficient NN cord-010092-uftc8inx 6826 4 S S NNP cord-010092-uftc8inx 6826 5 ) ) -RRB- cord-010092-uftc8inx 6826 6 and and CC cord-010092-uftc8inx 6826 7 light light JJ cord-010092-uftc8inx 6826 8 scattering scattering NN cord-010092-uftc8inx 6826 9 on on IN cord-010092-uftc8inx 6826 10 particles particle NNS cord-010092-uftc8inx 6826 11 with with IN cord-010092-uftc8inx 6826 12 size size NN cord-010092-uftc8inx 6826 13 D≥ D≥ NNP cord-010092-uftc8inx 6826 14 k k NN cord-010092-uftc8inx 6826 15 ( ( -LRB- cord-010092-uftc8inx 6826 16 coefficient coefficient NN cord-010092-uftc8inx 6826 17 K K NNP cord-010092-uftc8inx 6826 18 ) ) -RRB- cord-010092-uftc8inx 6826 19 were be VBD cord-010092-uftc8inx 6826 20 taken take VBN cord-010092-uftc8inx 6826 21 into into IN cord-010092-uftc8inx 6826 22 account account NN cord-010092-uftc8inx 6826 23 : : : cord-010092-uftc8inx 6827 1 D D NNP cord-010092-uftc8inx 6827 2 l l NN cord-010092-uftc8inx 6827 3 ( ( -LRB- cord-010092-uftc8inx 6827 4 k k NNP cord-010092-uftc8inx 6827 5 l l NNP cord-010092-uftc8inx 6827 6 ) ) -RRB- cord-010092-uftc8inx 6827 7 theor theor NN cord-010092-uftc8inx 6827 8 = = SYM cord-010092-uftc8inx 6827 9 e e NN cord-010092-uftc8inx 6827 10 HbO2,l HbO2,l NNP cord-010092-uftc8inx 6827 11 C c NN cord-010092-uftc8inx 6827 12 HbO2 hbo2 JJ cord-010092-uftc8inx 6828 1 L+ L+ NNP cord-010092-uftc8inx 6828 2 e e IN cord-010092-uftc8inx 6828 3 Hb Hb NNP cord-010092-uftc8inx 6828 4 , , , cord-010092-uftc8inx 6828 5 l l NNP cord-010092-uftc8inx 6828 6 C C NNP cord-010092-uftc8inx 6828 7 Hb Hb NNP cord-010092-uftc8inx 6828 8 L+ l+ ADD cord-010092-uftc8inx 6829 1 e e LS cord-010092-uftc8inx 6829 2 MetHb MetHb NNP cord-010092-uftc8inx 6829 3 , , , cord-010092-uftc8inx 6829 4 l l NNP cord-010092-uftc8inx 6829 5 C C NNP cord-010092-uftc8inx 6829 6 MetHb MetHb NNP cord-010092-uftc8inx 6829 7 L+ l+ XX cord-010092-uftc8inx 6829 8 e e DT cord-010092-uftc8inx 6829 9 HbNO HbNO NNP cord-010092-uftc8inx 6829 10 , , , cord-010092-uftc8inx 6829 11 l l NNP cord-010092-uftc8inx 6829 12 C C NNP cord-010092-uftc8inx 6829 13 HbNO HbNO NNP cord-010092-uftc8inx 6829 14 L+ l+ XX cord-010092-uftc8inx 6829 15 e e NN cord-010092-uftc8inx 6830 1 MetHbNO2 MetHbNO2 NNP cord-010092-uftc8inx 6830 2 -,l -,l HYPH cord-010092-uftc8inx 6830 3 C c NN cord-010092-uftc8inx 6830 4 MetHbNO2 MetHbNO2 NNP cord-010092-uftc8inx 6830 5 -L+ -L+ . cord-010092-uftc8inx 6831 1 e e LS cord-010092-uftc8inx 6831 2 MetHbNO MetHbNO NNP cord-010092-uftc8inx 6831 3 , , , cord-010092-uftc8inx 6831 4 l l NN cord-010092-uftc8inx 6831 5 C C NNP cord-010092-uftc8inx 6831 6 MetHbNO MetHbNO NNP cord-010092-uftc8inx 6831 7 L+K+S/ L+K+S/ NNP cord-010092-uftc8inx 6832 1 k k NNP cord-010092-uftc8inx 6832 2 4 4 CD cord-010092-uftc8inx 6832 3 l l NNP cord-010092-uftc8inx 6832 4 ( ( -LRB- cord-010092-uftc8inx 6832 5 1 1 CD cord-010092-uftc8inx 6832 6 ) ) -RRB- cord-010092-uftc8inx 6832 7 , , , cord-010092-uftc8inx 6832 8 where where WRB cord-010092-uftc8inx 6832 9 e e NNP cord-010092-uftc8inx 6832 10 h h NNP cord-010092-uftc8inx 6832 11 , , , cord-010092-uftc8inx 6832 12 l l NNP cord-010092-uftc8inx 6832 13 is be VBZ cord-010092-uftc8inx 6832 14 the the DT cord-010092-uftc8inx 6832 15 molar molar JJ cord-010092-uftc8inx 6832 16 absorption absorption NN cord-010092-uftc8inx 6832 17 coefficient coefficient NN cord-010092-uftc8inx 6832 18 for for IN cord-010092-uftc8inx 6832 19 each each DT cord-010092-uftc8inx 6832 20 Hb Hb NNP cord-010092-uftc8inx 6832 21 h h NN cord-010092-uftc8inx 6832 22 derivative derivative JJ cord-010092-uftc8inx 6832 23 at at IN cord-010092-uftc8inx 6832 24 given give VBN cord-010092-uftc8inx 6832 25 wavelengths wavelength NNS cord-010092-uftc8inx 6832 26 k k NNP cord-010092-uftc8inx 6832 27 l l NN cord-010092-uftc8inx 6833 1 , , , cord-010092-uftc8inx 6833 2 C C NNP cord-010092-uftc8inx 6833 3 h h NNP cord-010092-uftc8inx 6833 4 is be VBZ cord-010092-uftc8inx 6833 5 the the DT cord-010092-uftc8inx 6833 6 concentration concentration NN cord-010092-uftc8inx 6833 7 of of IN cord-010092-uftc8inx 6833 8 the the DT cord-010092-uftc8inx 6833 9 derivatives derivative NNS cord-010092-uftc8inx 6833 10 Hb Hb NNP cord-010092-uftc8inx 6833 11 h h NNP cord-010092-uftc8inx 6833 12 , , , cord-010092-uftc8inx 6833 13 L L NNP cord-010092-uftc8inx 6833 14 is be VBZ cord-010092-uftc8inx 6833 15 the the DT cord-010092-uftc8inx 6833 16 thickness thickness NN cord-010092-uftc8inx 6833 17 of of IN cord-010092-uftc8inx 6833 18 the the DT cord-010092-uftc8inx 6833 19 solution solution NN cord-010092-uftc8inx 6833 20 layer layer NN cord-010092-uftc8inx 6833 21 , , , cord-010092-uftc8inx 6833 22 D D NNP cord-010092-uftc8inx 6833 23 l l NN cord-010092-uftc8inx 6833 24 ( ( -LRB- cord-010092-uftc8inx 6833 25 k k NNP cord-010092-uftc8inx 6833 26 l l NNP cord-010092-uftc8inx 6833 27 ) ) -RRB- cord-010092-uftc8inx 6833 28 is be VBZ cord-010092-uftc8inx 6833 29 the the DT cord-010092-uftc8inx 6833 30 optical optical JJ cord-010092-uftc8inx 6833 31 density density NN cord-010092-uftc8inx 6833 32 of of IN cord-010092-uftc8inx 6833 33 the the DT cord-010092-uftc8inx 6833 34 substance substance NN cord-010092-uftc8inx 6833 35 , , , cord-010092-uftc8inx 6833 36 K K NNP cord-010092-uftc8inx 6833 37 and and CC cord-010092-uftc8inx 6833 38 S S NNP cord-010092-uftc8inx 6833 39 are be VBP cord-010092-uftc8inx 6833 40 the the DT cord-010092-uftc8inx 6833 41 parameters parameter NNS cord-010092-uftc8inx 6833 42 of of IN cord-010092-uftc8inx 6833 43 the the DT cord-010092-uftc8inx 6833 44 model model NN cord-010092-uftc8inx 6833 45 . . . cord-010092-uftc8inx 6834 1 Results result NNS cord-010092-uftc8inx 6835 1 : : : cord-010092-uftc8inx 6835 2 We -PRON- PRP cord-010092-uftc8inx 6835 3 determined determine VBD cord-010092-uftc8inx 6835 4 the the DT cord-010092-uftc8inx 6835 5 concentrations concentration NNS cord-010092-uftc8inx 6835 6 of of IN cord-010092-uftc8inx 6835 7 hemoglobin hemoglobin NN cord-010092-uftc8inx 6835 8 derivatives derivative NNS cord-010092-uftc8inx 6835 9 without without IN cord-010092-uftc8inx 6835 10 any any DT cord-010092-uftc8inx 6835 11 additional additional JJ cord-010092-uftc8inx 6835 12 chemicals chemical NNS cord-010092-uftc8inx 6835 13 in in IN cord-010092-uftc8inx 6835 14 blood blood NN cord-010092-uftc8inx 6835 15 . . . cord-010092-uftc8inx 6836 1 There there EX cord-010092-uftc8inx 6836 2 were be VBD cord-010092-uftc8inx 6836 3 measured measure VBN cord-010092-uftc8inx 6836 4 experimental experimental JJ cord-010092-uftc8inx 6836 5 spectra spectrum NNS cord-010092-uftc8inx 6836 6 for for IN cord-010092-uftc8inx 6836 7 different different JJ cord-010092-uftc8inx 6836 8 agents agent NNS cord-010092-uftc8inx 6836 9 action action NN cord-010092-uftc8inx 6836 10 on on IN cord-010092-uftc8inx 6836 11 blood blood NN cord-010092-uftc8inx 6836 12 . . . cord-010092-uftc8inx 6837 1 It -PRON- PRP cord-010092-uftc8inx 6837 2 was be VBD cord-010092-uftc8inx 6837 3 shown show VBN cord-010092-uftc8inx 6837 4 that that DT cord-010092-uftc8inx 6837 5 concentration concentration NN cord-010092-uftc8inx 6837 6 of of IN cord-010092-uftc8inx 6837 7 MetHb MetHb NNP cord-010092-uftc8inx 6837 8 increased increase VBD cord-010092-uftc8inx 6837 9 after after IN cord-010092-uftc8inx 6837 10 UV uv NN cord-010092-uftc8inx 6837 11 irradiation irradiation NN cord-010092-uftc8inx 6837 12 and and CC cord-010092-uftc8inx 6837 13 NaNO NaNO NNP cord-010092-uftc8inx 6837 14 2 2 CD cord-010092-uftc8inx 6837 15 action action NN cord-010092-uftc8inx 6837 16 ( ( -LRB- cord-010092-uftc8inx 6837 17 up up IN cord-010092-uftc8inx 6837 18 to to TO cord-010092-uftc8inx 6837 19 90 90 CD cord-010092-uftc8inx 6837 20 % % NN cord-010092-uftc8inx 6837 21 ) ) -RRB- cord-010092-uftc8inx 6837 22 . . . cord-010092-uftc8inx 6838 1 There there EX cord-010092-uftc8inx 6838 2 were be VBD cord-010092-uftc8inx 6838 3 calculated calculate VBN cord-010092-uftc8inx 6838 4 C C NNP cord-010092-uftc8inx 6838 5 h h NN cord-010092-uftc8inx 6838 6 for for IN cord-010092-uftc8inx 6838 7 each each DT cord-010092-uftc8inx 6838 8 Hb Hb NNP cord-010092-uftc8inx 6838 9 h h NN cord-010092-uftc8inx 6838 10 derivative derivative JJ cord-010092-uftc8inx 6838 11 . . . cord-010092-uftc8inx 6839 1 It -PRON- PRP cord-010092-uftc8inx 6839 2 was be VBD cord-010092-uftc8inx 6839 3 established establish VBN cord-010092-uftc8inx 6839 4 that that IN cord-010092-uftc8inx 6839 5 theoretical theoretical JJ cord-010092-uftc8inx 6839 6 curves curve NNS cord-010092-uftc8inx 6839 7 coincide coincide VBP cord-010092-uftc8inx 6839 8 with with IN cord-010092-uftc8inx 6839 9 experimental experimental JJ cord-010092-uftc8inx 6839 10 data datum NNS cord-010092-uftc8inx 6839 11 with with IN cord-010092-uftc8inx 6839 12 good good JJ cord-010092-uftc8inx 6839 13 accuracy accuracy NN cord-010092-uftc8inx 6840 1 ( ( -LRB- cord-010092-uftc8inx 6840 2 R r NN cord-010092-uftc8inx 6840 3 2 2 CD cord-010092-uftc8inx 6840 4 = = SYM cord-010092-uftc8inx 6840 5 0.98 0.98 CD cord-010092-uftc8inx 6840 6 ) ) -RRB- cord-010092-uftc8inx 6840 7 . . . cord-010092-uftc8inx 6841 1 Incubation incubation NN cord-010092-uftc8inx 6841 2 of of IN cord-010092-uftc8inx 6841 3 RBCs rbc NNS cord-010092-uftc8inx 6841 4 with with IN cord-010092-uftc8inx 6841 5 cytoflavin cytoflavin NNP cord-010092-uftc8inx 6841 6 leads lead NNS cord-010092-uftc8inx 6841 7 to to IN cord-010092-uftc8inx 6841 8 reduction reduction NN cord-010092-uftc8inx 6841 9 of of IN cord-010092-uftc8inx 6841 10 MetHb MetHb NNP cord-010092-uftc8inx 6841 11 to to IN cord-010092-uftc8inx 6841 12 HbO HbO NNP cord-010092-uftc8inx 6841 13 2 2 CD cord-010092-uftc8inx 6841 14 . . . cord-010092-uftc8inx 6842 1 Summary Summary NNP cord-010092-uftc8inx 6842 2 / / SYM cord-010092-uftc8inx 6842 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 6842 4 : : : cord-010092-uftc8inx 6843 1 The the DT cord-010092-uftc8inx 6843 2 determination determination NN cord-010092-uftc8inx 6843 3 of of IN cord-010092-uftc8inx 6843 4 hemoglobin hemoglobin NN cord-010092-uftc8inx 6843 5 derivative derivative JJ cord-010092-uftc8inx 6843 6 concentrations concentration NNS cord-010092-uftc8inx 6843 7 by by IN cord-010092-uftc8inx 6843 8 the the DT cord-010092-uftc8inx 6843 9 method method NN cord-010092-uftc8inx 6843 10 of of IN cord-010092-uftc8inx 6843 11 Nonlinear Nonlinear NNP cord-010092-uftc8inx 6843 12 Fitting Fitting NNP cord-010092-uftc8inx 6843 13 ( ( -LRB- cord-010092-uftc8inx 6843 14 without without IN cord-010092-uftc8inx 6843 15 adding add VBG cord-010092-uftc8inx 6843 16 special special JJ cord-010092-uftc8inx 6843 17 chemical chemical NN cord-010092-uftc8inx 6843 18 agents agent NNS cord-010092-uftc8inx 6843 19 to to IN cord-010092-uftc8inx 6843 20 blood blood NN cord-010092-uftc8inx 6843 21 ) ) -RRB- cord-010092-uftc8inx 6843 22 can can MD cord-010092-uftc8inx 6843 23 be be VB cord-010092-uftc8inx 6843 24 used use VBN cord-010092-uftc8inx 6843 25 for for IN cord-010092-uftc8inx 6843 26 measurement measurement NN cord-010092-uftc8inx 6843 27 of of IN cord-010092-uftc8inx 6843 28 carboxyhemoglobin carboxyhemoglobin NNP cord-010092-uftc8inx 6843 29 in in IN cord-010092-uftc8inx 6843 30 blood blood NN cord-010092-uftc8inx 6843 31 during during IN cord-010092-uftc8inx 6843 32 toxic toxic JJ cord-010092-uftc8inx 6843 33 state state NN cord-010092-uftc8inx 6843 34 of of IN cord-010092-uftc8inx 6843 35 organism organism NN cord-010092-uftc8inx 6843 36 . . . cord-010092-uftc8inx 6844 1 Also also RB cord-010092-uftc8inx 6844 2 it -PRON- PRP cord-010092-uftc8inx 6844 3 is be VBZ cord-010092-uftc8inx 6844 4 important important JJ cord-010092-uftc8inx 6844 5 for for IN cord-010092-uftc8inx 6844 6 assessment assessment NN cord-010092-uftc8inx 6844 7 of of IN cord-010092-uftc8inx 6844 8 RBCs rbc NNS cord-010092-uftc8inx 6844 9 quality quality NN cord-010092-uftc8inx 6844 10 before before IN cord-010092-uftc8inx 6844 11 blood blood NN cord-010092-uftc8inx 6844 12 transfusion transfusion NN cord-010092-uftc8inx 6844 13 . . . cord-010092-uftc8inx 6845 1 Background background NN cord-010092-uftc8inx 6845 2 : : : cord-010092-uftc8inx 6846 1 The the DT cord-010092-uftc8inx 6846 2 use use NN cord-010092-uftc8inx 6846 3 of of IN cord-010092-uftc8inx 6846 4 in in IN cord-010092-uftc8inx 6846 5 line line NN cord-010092-uftc8inx 6846 6 leukoreduction leukoreduction NN cord-010092-uftc8inx 6846 7 filters filter NNS cord-010092-uftc8inx 6846 8 have have VBP cord-010092-uftc8inx 6846 9 been be VBN cord-010092-uftc8inx 6846 10 highly highly RB cord-010092-uftc8inx 6846 11 expanded expand VBN cord-010092-uftc8inx 6846 12 in in IN cord-010092-uftc8inx 6846 13 Iranian Iranian NNP cord-010092-uftc8inx 6846 14 Blood Blood NNP cord-010092-uftc8inx 6846 15 Transfusion Transfusion NNP cord-010092-uftc8inx 6846 16 Centers Centers NNPS cord-010092-uftc8inx 6846 17 within within IN cord-010092-uftc8inx 6846 18 the the DT cord-010092-uftc8inx 6846 19 last last JJ cord-010092-uftc8inx 6846 20 decade decade NN cord-010092-uftc8inx 6846 21 in in IN cord-010092-uftc8inx 6846 22 order order NN cord-010092-uftc8inx 6846 23 to to TO cord-010092-uftc8inx 6846 24 provide provide VB cord-010092-uftc8inx 6846 25 sufficient sufficient JJ cord-010092-uftc8inx 6846 26 leukoreduced leukoreduced JJ cord-010092-uftc8inx 6846 27 blood blood NN cord-010092-uftc8inx 6846 28 fractions fraction NNS cord-010092-uftc8inx 6846 29 from from IN cord-010092-uftc8inx 6846 30 healthy healthy JJ cord-010092-uftc8inx 6846 31 safe safe JJ cord-010092-uftc8inx 6846 32 frequent frequent JJ cord-010092-uftc8inx 6846 33 blood blood NN cord-010092-uftc8inx 6846 34 donations donation NNS cord-010092-uftc8inx 6846 35 to to TO cord-010092-uftc8inx 6846 36 be be VB cord-010092-uftc8inx 6846 37 supplied supply VBN cord-010092-uftc8inx 6846 38 to to IN cord-010092-uftc8inx 6846 39 the the DT cord-010092-uftc8inx 6846 40 leukocyte leukocyte NN cord-010092-uftc8inx 6846 41 sensitive sensitive JJ cord-010092-uftc8inx 6846 42 patients patient NNS cord-010092-uftc8inx 6846 43 . . . cord-010092-uftc8inx 6847 1 Leukoflex Leukoflex NNP cord-010092-uftc8inx 6847 2 LCR5 LCR5 NNP cord-010092-uftc8inx 6847 3 , , , cord-010092-uftc8inx 6847 4 the the DT cord-010092-uftc8inx 6847 5 dominant dominant JJ cord-010092-uftc8inx 6847 6 brand brand NN cord-010092-uftc8inx 6847 7 of of IN cord-010092-uftc8inx 6847 8 such such JJ cord-010092-uftc8inx 6847 9 filters filter NNS cord-010092-uftc8inx 6847 10 procured procure VBN cord-010092-uftc8inx 6847 11 by by IN cord-010092-uftc8inx 6847 12 Iranian Iranian NNP cord-010092-uftc8inx 6847 13 Blood Blood NNP cord-010092-uftc8inx 6847 14 Transfusion Transfusion NNP cord-010092-uftc8inx 6847 15 Organization Organization NNP cord-010092-uftc8inx 6847 16 , , , cord-010092-uftc8inx 6847 17 is be VBZ cord-010092-uftc8inx 6847 18 the the DT cord-010092-uftc8inx 6847 19 most most RBS cord-010092-uftc8inx 6847 20 updated update VBN cord-010092-uftc8inx 6847 21 generation generation NN cord-010092-uftc8inx 6847 22 of of IN cord-010092-uftc8inx 6847 23 the the DT cord-010092-uftc8inx 6847 24 filters filter NNS cord-010092-uftc8inx 6847 25 used use VBN cord-010092-uftc8inx 6847 26 around around IN cord-010092-uftc8inx 6847 27 the the DT cord-010092-uftc8inx 6847 28 world world NN cord-010092-uftc8inx 6847 29 . . . cord-010092-uftc8inx 6848 1 Aims aim VBZ cord-010092-uftc8inx 6848 2 : : : cord-010092-uftc8inx 6849 1 In in IN cord-010092-uftc8inx 6849 2 this this DT cord-010092-uftc8inx 6849 3 study study NN cord-010092-uftc8inx 6849 4 , , , cord-010092-uftc8inx 6849 5 it -PRON- PRP cord-010092-uftc8inx 6849 6 is be VBZ cord-010092-uftc8inx 6849 7 tried try VBN cord-010092-uftc8inx 6849 8 to to TO cord-010092-uftc8inx 6849 9 recover recover VB cord-010092-uftc8inx 6849 10 the the DT cord-010092-uftc8inx 6849 11 trapped trap VBN cord-010092-uftc8inx 6849 12 leukocytes leukocyte NNS cord-010092-uftc8inx 6849 13 from from IN cord-010092-uftc8inx 6849 14 this this DT cord-010092-uftc8inx 6849 15 novel novel JJ cord-010092-uftc8inx 6849 16 filter filter NN cord-010092-uftc8inx 6849 17 by by IN cord-010092-uftc8inx 6849 18 different different JJ cord-010092-uftc8inx 6849 19 buffering buffering NN cord-010092-uftc8inx 6849 20 systems system NNS cord-010092-uftc8inx 6849 21 and and CC cord-010092-uftc8inx 6849 22 having have VBG cord-010092-uftc8inx 6849 23 optimized optimize VBN cord-010092-uftc8inx 6849 24 the the DT cord-010092-uftc8inx 6849 25 elution elution NN cord-010092-uftc8inx 6849 26 mode mode NN cord-010092-uftc8inx 6849 27 , , , cord-010092-uftc8inx 6849 28 the the DT cord-010092-uftc8inx 6849 29 cell cell NN cord-010092-uftc8inx 6849 30 differential differential NN cord-010092-uftc8inx 6849 31 of of IN cord-010092-uftc8inx 6849 32 the the DT cord-010092-uftc8inx 6849 33 viable viable JJ cord-010092-uftc8inx 6849 34 recovered recover VBN cord-010092-uftc8inx 6849 35 white white JJ cord-010092-uftc8inx 6849 36 blood blood NN cord-010092-uftc8inx 6849 37 cells cell NNS cord-010092-uftc8inx 6849 38 were be VBD cord-010092-uftc8inx 6849 39 determined determine VBN cord-010092-uftc8inx 6849 40 by by IN cord-010092-uftc8inx 6849 41 flow flow NN cord-010092-uftc8inx 6849 42 cytometry cytometry NN cord-010092-uftc8inx 6849 43 . . . cord-010092-uftc8inx 6850 1 Methods method NNS cord-010092-uftc8inx 6850 2 : : : cord-010092-uftc8inx 6850 3 Having have VBG cord-010092-uftc8inx 6850 4 passed pass VBN cord-010092-uftc8inx 6850 5 the the DT cord-010092-uftc8inx 6850 6 routine routine JJ cord-010092-uftc8inx 6850 7 virological virological JJ cord-010092-uftc8inx 6850 8 tests test NNS cord-010092-uftc8inx 6850 9 , , , cord-010092-uftc8inx 6850 10 eight eight CD cord-010092-uftc8inx 6850 11 Leukoflex Leukoflex NNP cord-010092-uftc8inx 6850 12 LCR5 LCR5 NNP cord-010092-uftc8inx 6850 13 leukoreduction leukoreduction NN cord-010092-uftc8inx 6850 14 filters filter VBZ cord-010092-uftc8inx 6850 15 freshly freshly RB cord-010092-uftc8inx 6850 16 used use VBN cord-010092-uftc8inx 6850 17 in in IN cord-010092-uftc8inx 6850 18 Tehran Tehran NNP cord-010092-uftc8inx 6850 19 Blood Blood NNP cord-010092-uftc8inx 6850 20 Transfusion Transfusion NNP cord-010092-uftc8inx 6850 21 Center Center NNP cord-010092-uftc8inx 6850 22 were be VBD cord-010092-uftc8inx 6850 23 daily daily RB cord-010092-uftc8inx 6850 24 collected collect VBN cord-010092-uftc8inx 6850 25 and and CC cord-010092-uftc8inx 6850 26 each each DT cord-010092-uftc8inx 6850 27 were be VBD cord-010092-uftc8inx 6850 28 back back RB cord-010092-uftc8inx 6850 29 flushed flush VBN cord-010092-uftc8inx 6850 30 by by IN cord-010092-uftc8inx 6850 31 a a DT cord-010092-uftc8inx 6850 32 self self NN cord-010092-uftc8inx 6850 33 - - HYPH cord-010092-uftc8inx 6850 34 designed design VBN cord-010092-uftc8inx 6850 35 mechanical mechanical JJ cord-010092-uftc8inx 6850 36 system system NN cord-010092-uftc8inx 6850 37 ( ( -LRB- cord-010092-uftc8inx 6850 38 a a DT cord-010092-uftc8inx 6850 39 peristaltic peristaltic JJ cord-010092-uftc8inx 6850 40 pump pump NN cord-010092-uftc8inx 6850 41 , , , cord-010092-uftc8inx 6850 42 a a DT cord-010092-uftc8inx 6850 43 triple triple JJ cord-010092-uftc8inx 6850 44 junction junction NN cord-010092-uftc8inx 6850 45 with with IN cord-010092-uftc8inx 6850 46 regulator regulator NN cord-010092-uftc8inx 6850 47 part part NN cord-010092-uftc8inx 6850 48 and and CC cord-010092-uftc8inx 6850 49 an an DT cord-010092-uftc8inx 6850 50 air air NN cord-010092-uftc8inx 6850 51 pump pump NN cord-010092-uftc8inx 6850 52 ) ) -RRB- cord-010092-uftc8inx 6850 53 using use VBG cord-010092-uftc8inx 6850 54 various various JJ cord-010092-uftc8inx 6850 55 conditions condition NNS cord-010092-uftc8inx 6850 56 and and CC cord-010092-uftc8inx 6850 57 additives additive NNS cord-010092-uftc8inx 6850 58 for for IN cord-010092-uftc8inx 6850 59 PBS PBS NNP cord-010092-uftc8inx 6850 60 buffer buffer NN cord-010092-uftc8inx 6850 61 at at IN cord-010092-uftc8inx 6850 62 different different JJ cord-010092-uftc8inx 6850 63 pHs ph NNS cord-010092-uftc8inx 6850 64 in in IN cord-010092-uftc8inx 6850 65 order order NN cord-010092-uftc8inx 6850 66 to to TO cord-010092-uftc8inx 6850 67 find find VB cord-010092-uftc8inx 6850 68 the the DT cord-010092-uftc8inx 6850 69 highest high JJS cord-010092-uftc8inx 6850 70 recovery recovery NN cord-010092-uftc8inx 6850 71 yield yield NN cord-010092-uftc8inx 6850 72 for for IN cord-010092-uftc8inx 6850 73 Leukocytes Leukocytes NNP cord-010092-uftc8inx 6850 74 . . . cord-010092-uftc8inx 6851 1 The the DT cord-010092-uftc8inx 6851 2 optimized optimized JJ cord-010092-uftc8inx 6851 3 elute elute NN cord-010092-uftc8inx 6851 4 was be VBD cord-010092-uftc8inx 6851 5 characterized characterize VBN cord-010092-uftc8inx 6851 6 by by IN cord-010092-uftc8inx 6851 7 flow flow NN cord-010092-uftc8inx 6851 8 cytometry cytometry NN cord-010092-uftc8inx 6851 9 for for IN cord-010092-uftc8inx 6851 10 subcellular subcellular JJ cord-010092-uftc8inx 6851 11 profile profile NN cord-010092-uftc8inx 6851 12 to to TO cord-010092-uftc8inx 6851 13 be be VB cord-010092-uftc8inx 6851 14 determined determine VBN cord-010092-uftc8inx 6851 15 . . . cord-010092-uftc8inx 6852 1 Results result NNS cord-010092-uftc8inx 6852 2 : : : cord-010092-uftc8inx 6853 1 It -PRON- PRP cord-010092-uftc8inx 6853 2 was be VBD cord-010092-uftc8inx 6853 3 illustrated illustrate VBN cord-010092-uftc8inx 6853 4 that that IN cord-010092-uftc8inx 6853 5 a a DT cord-010092-uftc8inx 6853 6 system system NN cord-010092-uftc8inx 6853 7 consisting consist VBG cord-010092-uftc8inx 6853 8 of of IN cord-010092-uftc8inx 6853 9 PBS PBS NNP cord-010092-uftc8inx 6853 10 ( ( -LRB- cord-010092-uftc8inx 6853 11 without without IN cord-010092-uftc8inx 6853 12 CaCl2 cacl2 NN cord-010092-uftc8inx 6853 13 and and CC cord-010092-uftc8inx 6853 14 MgCl2 mgcl2 NN cord-010092-uftc8inx 6853 15 ) ) -RRB- cord-010092-uftc8inx 6853 16 in in IN cord-010092-uftc8inx 6853 17 pH pH NNP cord-010092-uftc8inx 6853 18 7.2 7.2 CD cord-010092-uftc8inx 6853 19 containing contain VBG cord-010092-uftc8inx 6853 20 2 2 CD cord-010092-uftc8inx 6853 21 mM mm CD cord-010092-uftc8inx 6853 22 EDTA EDTA NNP cord-010092-uftc8inx 6853 23 and and CC cord-010092-uftc8inx 6853 24 4%(w 4%(w CD cord-010092-uftc8inx 6853 25 / / SYM cord-010092-uftc8inx 6853 26 w w NN cord-010092-uftc8inx 6853 27 ) ) -RRB- cord-010092-uftc8inx 6853 28 Dextran dextran NN cord-010092-uftc8inx 6853 29 40 40 CD cord-010092-uftc8inx 6853 30 without without IN cord-010092-uftc8inx 6853 31 additive additive NN cord-010092-uftc8inx 6853 32 amounts amount NNS cord-010092-uftc8inx 6853 33 of of IN cord-010092-uftc8inx 6853 34 Triton Triton NNP cord-010092-uftc8inx 6853 35 X100 X100 NNS cord-010092-uftc8inx 6853 36 was be VBD cord-010092-uftc8inx 6853 37 the the DT cord-010092-uftc8inx 6853 38 most most RBS cord-010092-uftc8inx 6853 39 optimized optimize VBN cord-010092-uftc8inx 6853 40 buffering buffer VBG cord-010092-uftc8inx 6853 41 system system NN cord-010092-uftc8inx 6853 42 for for IN cord-010092-uftc8inx 6853 43 LCR5 LCR5 NNP cord-010092-uftc8inx 6853 44 filter filter NN cord-010092-uftc8inx 6853 45 back back RB cord-010092-uftc8inx 6853 46 flushing flushing NN cord-010092-uftc8inx 6853 47 . . . cord-010092-uftc8inx 6854 1 Total total JJ cord-010092-uftc8inx 6854 2 cell cell NN cord-010092-uftc8inx 6854 3 content content NN cord-010092-uftc8inx 6854 4 was be VBD cord-010092-uftc8inx 6854 5 also also RB cord-010092-uftc8inx 6854 6 determined determine VBN cord-010092-uftc8inx 6854 7 as as IN cord-010092-uftc8inx 6854 8 6.28 6.28 CD cord-010092-uftc8inx 6854 9 * * NFP cord-010092-uftc8inx 6854 10 10 10 CD cord-010092-uftc8inx 6854 11 8 8 CD cord-010092-uftc8inx 6854 12 Granulocytes granulocyte NNS cord-010092-uftc8inx 6854 13 , , , cord-010092-uftc8inx 6854 14 4.27 4.27 CD cord-010092-uftc8inx 6854 15 * * NFP cord-010092-uftc8inx 6854 16 10 10 CD cord-010092-uftc8inx 6854 17 8 8 CD cord-010092-uftc8inx 6854 18 Lymphocytes lymphocyte NNS cord-010092-uftc8inx 6854 19 and and CC cord-010092-uftc8inx 6854 20 0.8 0.8 CD cord-010092-uftc8inx 6854 21 * * NFP cord-010092-uftc8inx 6854 22 10 10 CD cord-010092-uftc8inx 6854 23 8 8 CD cord-010092-uftc8inx 6854 24 Monocytes Monocytes NNPS cord-010092-uftc8inx 6854 25 using use VBG cord-010092-uftc8inx 6854 26 auto auto NN cord-010092-uftc8inx 6854 27 hemoanalysis hemoanalysis NN cord-010092-uftc8inx 6854 28 and and CC cord-010092-uftc8inx 6854 29 flow flow NN cord-010092-uftc8inx 6854 30 cytometric cytometric NN cord-010092-uftc8inx 6854 31 methods method NNS cord-010092-uftc8inx 6854 32 . . . cord-010092-uftc8inx 6855 1 Summary Summary NNP cord-010092-uftc8inx 6855 2 / / SYM cord-010092-uftc8inx 6855 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 6855 4 : : : cord-010092-uftc8inx 6856 1 In in IN cord-010092-uftc8inx 6856 2 addition addition NN cord-010092-uftc8inx 6856 3 to to IN cord-010092-uftc8inx 6856 4 partly partly RB cord-010092-uftc8inx 6856 5 compensating compensate VBG cord-010092-uftc8inx 6856 6 of of IN cord-010092-uftc8inx 6856 7 the the DT cord-010092-uftc8inx 6856 8 overhead overhead JJ cord-010092-uftc8inx 6856 9 expenses expense NNS cord-010092-uftc8inx 6856 10 inflicted inflict VBN cord-010092-uftc8inx 6856 11 by by IN cord-010092-uftc8inx 6856 12 application application NN cord-010092-uftc8inx 6856 13 of of IN cord-010092-uftc8inx 6856 14 leukoreduction leukoreduction NN cord-010092-uftc8inx 6856 15 filters filter NNS cord-010092-uftc8inx 6856 16 on on IN cord-010092-uftc8inx 6856 17 healthcare healthcare NN cord-010092-uftc8inx 6856 18 system system NN cord-010092-uftc8inx 6856 19 , , , cord-010092-uftc8inx 6856 20 the the DT cord-010092-uftc8inx 6856 21 results result NNS cord-010092-uftc8inx 6856 22 will will MD cord-010092-uftc8inx 6856 23 assist assist VB cord-010092-uftc8inx 6856 24 blood blood NN cord-010092-uftc8inx 6856 25 organization organization NN cord-010092-uftc8inx 6856 26 system system NN cord-010092-uftc8inx 6856 27 to to TO cord-010092-uftc8inx 6856 28 be be VB cord-010092-uftc8inx 6856 29 more more RBR cord-010092-uftc8inx 6856 30 classified classified JJ cord-010092-uftc8inx 6856 31 in in IN cord-010092-uftc8inx 6856 32 rational rational JJ cord-010092-uftc8inx 6856 33 profile profile NN cord-010092-uftc8inx 6856 34 design design NN cord-010092-uftc8inx 6856 35 , , , cord-010092-uftc8inx 6856 36 future future JJ cord-010092-uftc8inx 6856 37 cell cell NN cord-010092-uftc8inx 6856 38 therapy therapy NN cord-010092-uftc8inx 6856 39 strategies strategy NNS cord-010092-uftc8inx 6856 40 and and CC cord-010092-uftc8inx 6856 41 exceptional exceptional JJ cord-010092-uftc8inx 6856 42 blood blood NN cord-010092-uftc8inx 6856 43 management management NN cord-010092-uftc8inx 6856 44 . . . cord-010092-uftc8inx 6857 1 Also also RB cord-010092-uftc8inx 6857 2 , , , cord-010092-uftc8inx 6857 3 the the DT cord-010092-uftc8inx 6857 4 recovered recover VBN cord-010092-uftc8inx 6857 5 cells cell NNS cord-010092-uftc8inx 6857 6 could could MD cord-010092-uftc8inx 6857 7 be be VB cord-010092-uftc8inx 6857 8 of of IN cord-010092-uftc8inx 6857 9 significance significance NN cord-010092-uftc8inx 6857 10 in in IN cord-010092-uftc8inx 6857 11 stem stem NN cord-010092-uftc8inx 6857 12 cell cell NN cord-010092-uftc8inx 6857 13 science science NN cord-010092-uftc8inx 6857 14 , , , cord-010092-uftc8inx 6857 15 cellular cellular JJ cord-010092-uftc8inx 6857 16 interaction interaction NN cord-010092-uftc8inx 6857 17 studies study NNS cord-010092-uftc8inx 6857 18 as as RB cord-010092-uftc8inx 6857 19 well well RB cord-010092-uftc8inx 6857 20 as as IN cord-010092-uftc8inx 6857 21 novel novel JJ cord-010092-uftc8inx 6857 22 molecular molecular JJ cord-010092-uftc8inx 6857 23 developments development NNS cord-010092-uftc8inx 6857 24 in in IN cord-010092-uftc8inx 6857 25 drug drug NN cord-010092-uftc8inx 6857 26 discovery discovery NN cord-010092-uftc8inx 6857 27 . . . cord-010092-uftc8inx 6858 1 Vox Vox NNP cord-010092-uftc8inx 6858 2 Sanguinis Sanguinis NNP cord-010092-uftc8inx 6858 3 ( ( -LRB- cord-010092-uftc8inx 6858 4 2019 2019 CD cord-010092-uftc8inx 6858 5 ) ) -RRB- cord-010092-uftc8inx 6858 6 Results result NNS cord-010092-uftc8inx 6858 7 : : : cord-010092-uftc8inx 6858 8 Three three CD cord-010092-uftc8inx 6858 9 lines line NNS cord-010092-uftc8inx 6858 10 of of IN cord-010092-uftc8inx 6858 11 strategy strategy NN cord-010092-uftc8inx 6858 12 are be VBP cord-010092-uftc8inx 6858 13 in in IN cord-010092-uftc8inx 6858 14 place place NN cord-010092-uftc8inx 6858 15 to to TO cord-010092-uftc8inx 6858 16 pursue pursue VB cord-010092-uftc8inx 6858 17 self self NN cord-010092-uftc8inx 6858 18 - - HYPH cord-010092-uftc8inx 6858 19 sufficiency sufficiency NN cord-010092-uftc8inx 6858 20 of of IN cord-010092-uftc8inx 6858 21 the the DT cord-010092-uftc8inx 6858 22 largest large JJS cord-010092-uftc8inx 6858 23 number number NN cord-010092-uftc8inx 6858 24 of of IN cord-010092-uftc8inx 6858 25 PDMPs pdmp NNS cord-010092-uftc8inx 6858 26 . . . cord-010092-uftc8inx 6859 1 First first JJ cord-010092-uftc8inx 6859 2 strategy strategy NN cord-010092-uftc8inx 6859 3 line line NN cord-010092-uftc8inx 6859 4 : : : cord-010092-uftc8inx 6859 5 maximizing maximize VBG cord-010092-uftc8inx 6859 6 the the DT cord-010092-uftc8inx 6859 7 yield yield NN cord-010092-uftc8inx 6859 8 of of IN cord-010092-uftc8inx 6859 9 driving drive VBG cord-010092-uftc8inx 6859 10 proteins protein NNS cord-010092-uftc8inx 6859 11 , , , cord-010092-uftc8inx 6859 12 represented represent VBN cord-010092-uftc8inx 6859 13 by by IN cord-010092-uftc8inx 6859 14 Immunoglobulins Immunoglobulins NNP cord-010092-uftc8inx 6859 15 ( ( -LRB- cord-010092-uftc8inx 6859 16 Ig Ig NNP cord-010092-uftc8inx 6859 17 ) ) -RRB- cord-010092-uftc8inx 6859 18 and and CC cord-010092-uftc8inx 6859 19 albumin albumin NN cord-010092-uftc8inx 6860 1 ; ; : cord-010092-uftc8inx 6860 2 this this DT cord-010092-uftc8inx 6860 3 was be VBD cord-010092-uftc8inx 6860 4 assured assure VBN cord-010092-uftc8inx 6860 5 by by IN cord-010092-uftc8inx 6860 6 CSL CSL NNP cord-010092-uftc8inx 6860 7 Behring Behring NNP cord-010092-uftc8inx 6860 8 with with IN cord-010092-uftc8inx 6860 9 a a DT cord-010092-uftc8inx 6860 10 yield yield NN cord-010092-uftc8inx 6860 11 of of IN cord-010092-uftc8inx 6860 12 5.2 5.2 CD cord-010092-uftc8inx 6860 13 g g NN cord-010092-uftc8inx 6860 14 Ig ig NN cord-010092-uftc8inx 6860 15 ( ( -LRB- cord-010092-uftc8inx 6860 16 70 70 CD cord-010092-uftc8inx 6860 17 % % NN cord-010092-uftc8inx 6860 18 intravenous intravenous JJ cord-010092-uftc8inx 6860 19 -Privigenand -Privigenand : cord-010092-uftc8inx 6860 20 30 30 CD cord-010092-uftc8inx 6860 21 % % NN cord-010092-uftc8inx 6860 22 subcutaneous subcutaneous JJ cord-010092-uftc8inx 6860 23 -Hizentra -Hizentra NNS cord-010092-uftc8inx 6860 24 ) ) -RRB- cord-010092-uftc8inx 6860 25 and and CC cord-010092-uftc8inx 6860 26 26 26 CD cord-010092-uftc8inx 6860 27 g g NN cord-010092-uftc8inx 6860 28 albumin albumin NN cord-010092-uftc8inx 6860 29 ( ( -LRB- cord-010092-uftc8inx 6860 30 Alburex Alburex NNP cord-010092-uftc8inx 6860 31 ) ) -RRB- cord-010092-uftc8inx 6860 32 per per IN cord-010092-uftc8inx 6860 33 Kg Kg NNP cord-010092-uftc8inx 6860 34 plasma plasma NN cord-010092-uftc8inx 6860 35 fractionated fractionate VBN cord-010092-uftc8inx 6860 36 , , , cord-010092-uftc8inx 6860 37 corresponding correspond VBG cord-010092-uftc8inx 6860 38 to to IN cord-010092-uftc8inx 6860 39 998.000 998.000 CD cord-010092-uftc8inx 6860 40 g g NN cord-010092-uftc8inx 6860 41 Ig ig NN cord-010092-uftc8inx 6860 42 and and CC cord-010092-uftc8inx 6860 43 4.992.000 4.992.000 CD cord-010092-uftc8inx 6860 44 g g NN cord-010092-uftc8inx 6860 45 albumin albumin NN cord-010092-uftc8inx 6860 46 ; ; : cord-010092-uftc8inx 6860 47 based base VBN cord-010092-uftc8inx 6860 48 on on IN cord-010092-uftc8inx 6860 49 present present JJ cord-010092-uftc8inx 6860 50 demand demand NN cord-010092-uftc8inx 6860 51 , , , cord-010092-uftc8inx 6860 52 this this DT cord-010092-uftc8inx 6860 53 represents represent VBZ cord-010092-uftc8inx 6860 54 97 97 CD cord-010092-uftc8inx 6860 55 % % NN cord-010092-uftc8inx 6860 56 and and CC cord-010092-uftc8inx 6860 57 100 100 CD cord-010092-uftc8inx 6860 58 % % NN cord-010092-uftc8inx 6860 59 self self NN cord-010092-uftc8inx 6860 60 - - HYPH cord-010092-uftc8inx 6860 61 sufficiency sufficiency NN cord-010092-uftc8inx 6860 62 , , , cord-010092-uftc8inx 6860 63 respectively respectively RB cord-010092-uftc8inx 6860 64 , , , cord-010092-uftc8inx 6860 65 for for IN cord-010092-uftc8inx 6860 66 NAIP naip NN cord-010092-uftc8inx 6860 67 regions region NNS cord-010092-uftc8inx 6860 68 . . . cord-010092-uftc8inx 6861 1 Second second JJ cord-010092-uftc8inx 6861 2 strategy strategy NN cord-010092-uftc8inx 6861 3 line line NN cord-010092-uftc8inx 6861 4 : : : cord-010092-uftc8inx 6861 5 ensuring ensure VBG cord-010092-uftc8inx 6861 6 other other JJ cord-010092-uftc8inx 6861 7 products product NNS cord-010092-uftc8inx 6861 8 from from IN cord-010092-uftc8inx 6861 9 plasma plasma NN cord-010092-uftc8inx 6861 10 fractionation fractionation NN cord-010092-uftc8inx 6861 11 ; ; : cord-010092-uftc8inx 6861 12 the the DT cord-010092-uftc8inx 6861 13 fractionator fractionator NN cord-010092-uftc8inx 6861 14 granted grant VBD cord-010092-uftc8inx 6861 15 6.000 6.000 CD cord-010092-uftc8inx 6861 16 g g NN cord-010092-uftc8inx 6861 17 fibrinogen fibrinogen NN cord-010092-uftc8inx 6861 18 ( ( -LRB- cord-010092-uftc8inx 6861 19 Riastap Riastap NNP cord-010092-uftc8inx 6861 20 ) ) -RRB- cord-010092-uftc8inx 6861 21 and and CC cord-010092-uftc8inx 6861 22 6.000.000 6.000.000 CD cord-010092-uftc8inx 6862 1 IU IU NNP cord-010092-uftc8inx 6862 2 vWF vWF NNP cord-010092-uftc8inx 6862 3 / / SYM cord-010092-uftc8inx 6862 4 FVIII FVIII NNP cord-010092-uftc8inx 6862 5 ( ( -LRB- cord-010092-uftc8inx 6862 6 Haemate Haemate NNP cord-010092-uftc8inx 6862 7 P P NNP cord-010092-uftc8inx 6862 8 ) ) -RRB- cord-010092-uftc8inx 6862 9 per per IN cord-010092-uftc8inx 6862 10 year year NN cord-010092-uftc8inx 6862 11 , , , cord-010092-uftc8inx 6862 12 which which WDT cord-010092-uftc8inx 6862 13 corresponds correspond VBZ cord-010092-uftc8inx 6862 14 to to IN cord-010092-uftc8inx 6862 15 the the DT cord-010092-uftc8inx 6862 16 present present JJ cord-010092-uftc8inx 6862 17 demand demand NN cord-010092-uftc8inx 6862 18 of of IN cord-010092-uftc8inx 6862 19 NAIP NAIP NNP cord-010092-uftc8inx 6862 20 Regions Regions NNPS cord-010092-uftc8inx 6862 21 for for IN cord-010092-uftc8inx 6862 22 both both DT cord-010092-uftc8inx 6862 23 products product NNS cord-010092-uftc8inx 6862 24 , , , cord-010092-uftc8inx 6862 25 but but CC cord-010092-uftc8inx 6862 26 it -PRON- PRP cord-010092-uftc8inx 6862 27 is be VBZ cord-010092-uftc8inx 6862 28 under under IN cord-010092-uftc8inx 6862 29 the the DT cord-010092-uftc8inx 6862 30 full full JJ cord-010092-uftc8inx 6862 31 potential potential NN cord-010092-uftc8inx 6862 32 of of IN cord-010092-uftc8inx 6862 33 plasma plasma NN cord-010092-uftc8inx 6862 34 , , , cord-010092-uftc8inx 6862 35 thus thus RB cord-010092-uftc8inx 6862 36 providing provide VBG cord-010092-uftc8inx 6862 37 a a DT cord-010092-uftc8inx 6862 38 high high JJ cord-010092-uftc8inx 6862 39 margin margin NN cord-010092-uftc8inx 6862 40 of of IN cord-010092-uftc8inx 6862 41 safety safety NN cord-010092-uftc8inx 6862 42 in in IN cord-010092-uftc8inx 6862 43 case case NN cord-010092-uftc8inx 6862 44 of of IN cord-010092-uftc8inx 6862 45 increased increase VBN cord-010092-uftc8inx 6862 46 demand demand NN cord-010092-uftc8inx 6862 47 ( ( -LRB- cord-010092-uftc8inx 6862 48 now now RB cord-010092-uftc8inx 6862 49 the the DT cord-010092-uftc8inx 6862 50 case case NN cord-010092-uftc8inx 6862 51 of of IN cord-010092-uftc8inx 6862 52 fibrinogen fibrinogen NN cord-010092-uftc8inx 6862 53 ) ) -RRB- cord-010092-uftc8inx 6862 54 . . . cord-010092-uftc8inx 6863 1 Third third JJ cord-010092-uftc8inx 6863 2 strategy strategy NN cord-010092-uftc8inx 6863 3 line line NN cord-010092-uftc8inx 6863 4 : : : cord-010092-uftc8inx 6863 5 exchanging exchange VBG cord-010092-uftc8inx 6863 6 cryoprecipitate cryoprecipitate NNP cord-010092-uftc8inx 6863 7 , , , cord-010092-uftc8inx 6863 8 Fibrinogen Fibrinogen NNP cord-010092-uftc8inx 6863 9 and and CC cord-010092-uftc8inx 6863 10 vWF vwf NN cord-010092-uftc8inx 6863 11 with with IN cord-010092-uftc8inx 6863 12 Italian italian JJ cord-010092-uftc8inx 6863 13 Regions region NNS cord-010092-uftc8inx 6863 14 whose whose WP$ cord-010092-uftc8inx 6863 15 plasma plasma NN cord-010092-uftc8inx 6863 16 is be VBZ cord-010092-uftc8inx 6863 17 fractionated fractionate VBN cord-010092-uftc8inx 6863 18 by by IN cord-010092-uftc8inx 6863 19 other other JJ cord-010092-uftc8inx 6863 20 companies company NNS cord-010092-uftc8inx 6863 21 to to TO cord-010092-uftc8inx 6863 22 obtain obtain VB cord-010092-uftc8inx 6863 23 Prothrombin Prothrombin NNP cord-010092-uftc8inx 6863 24 Complex Complex NNP cord-010092-uftc8inx 6863 25 Concentrates Concentrates NNPS cord-010092-uftc8inx 6863 26 ( ( -LRB- cord-010092-uftc8inx 6863 27 PCC PCC NNP cord-010092-uftc8inx 6863 28 -Kedcom -kedcom ADD cord-010092-uftc8inx 6863 29 ) ) -RRB- cord-010092-uftc8inx 6863 30 and and CC cord-010092-uftc8inx 6863 31 Antithrombin Antithrombin NNP cord-010092-uftc8inx 6863 32 ( ( -LRB- cord-010092-uftc8inx 6863 33 ATKED ATKED NNP cord-010092-uftc8inx 6863 34 ) ) -RRB- cord-010092-uftc8inx 6863 35 as as IN cord-010092-uftc8inx 6863 36 to to TO cord-010092-uftc8inx 6863 37 satisfy satisfy VB cord-010092-uftc8inx 6863 38 NAIP NAIP NNP cord-010092-uftc8inx 6863 39 regions region NNS cord-010092-uftc8inx 6863 40 demand demand VBP cord-010092-uftc8inx 6864 1 ; ; : cord-010092-uftc8inx 6864 2 this this DT cord-010092-uftc8inx 6864 3 strategy strategy NN cord-010092-uftc8inx 6864 4 allowed allow VBD cord-010092-uftc8inx 6864 5 a a DT cord-010092-uftc8inx 6864 6 supply supply NN cord-010092-uftc8inx 6864 7 of of IN cord-010092-uftc8inx 6864 8 5.000.000 5.000.000 CD cord-010092-uftc8inx 6864 9 IU IU NNP cord-010092-uftc8inx 6864 10 AT AT NNP cord-010092-uftc8inx 6864 11 and and CC cord-010092-uftc8inx 6864 12 3.000.000 3.000.000 CD cord-010092-uftc8inx 6864 13 IU IU NNP cord-010092-uftc8inx 6864 14 PCC PCC NNP cord-010092-uftc8inx 6864 15 , , , cord-010092-uftc8inx 6864 16 capable capable JJ cord-010092-uftc8inx 6864 17 of of IN cord-010092-uftc8inx 6864 18 ensuring ensure VBG cord-010092-uftc8inx 6864 19 self self NN cord-010092-uftc8inx 6864 20 - - HYPH cord-010092-uftc8inx 6864 21 sufficiency sufficiency NN cord-010092-uftc8inx 6864 22 for for IN cord-010092-uftc8inx 6864 23 NAIP NAIP NNP cord-010092-uftc8inx 6864 24 Regions Regions NNPS cord-010092-uftc8inx 6864 25 until until IN cord-010092-uftc8inx 6864 26 2020 2020 CD cord-010092-uftc8inx 6864 27 . . . cord-010092-uftc8inx 6865 1 Summary Summary NNP cord-010092-uftc8inx 6865 2 / / SYM cord-010092-uftc8inx 6865 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 6865 4 : : : cord-010092-uftc8inx 6866 1 In in IN cord-010092-uftc8inx 6866 2 Italy Italy NNP cord-010092-uftc8inx 6866 3 , , , cord-010092-uftc8inx 6866 4 differentiation differentiation NN cord-010092-uftc8inx 6866 5 of of IN cord-010092-uftc8inx 6866 6 plasma plasma NN cord-010092-uftc8inx 6866 7 contract contract NN cord-010092-uftc8inx 6866 8 manufacturing manufacturing NN cord-010092-uftc8inx 6866 9 among among IN cord-010092-uftc8inx 6866 10 companies company NNS cord-010092-uftc8inx 6866 11 with with IN cord-010092-uftc8inx 6866 12 different different JJ cord-010092-uftc8inx 6866 13 portfolios portfolio NNS cord-010092-uftc8inx 6866 14 allowed allow VBD cord-010092-uftc8inx 6866 15 NAIP NAIP NNP cord-010092-uftc8inx 6866 16 Regions region NNS cord-010092-uftc8inx 6866 17 to to TO cord-010092-uftc8inx 6866 18 obtain obtain VB cord-010092-uftc8inx 6866 19 a a DT cord-010092-uftc8inx 6866 20 significant significant JJ cord-010092-uftc8inx 6866 21 contribution contribution NN cord-010092-uftc8inx 6866 22 to to IN cord-010092-uftc8inx 6866 23 self self NN cord-010092-uftc8inx 6866 24 - - HYPH cord-010092-uftc8inx 6866 25 sufficiency sufficiency NN cord-010092-uftc8inx 6866 26 from from IN cord-010092-uftc8inx 6866 27 VNRD VNRD NNP cord-010092-uftc8inx 6866 28 plasma plasma NN cord-010092-uftc8inx 6866 29 for for IN cord-010092-uftc8inx 6866 30 a a DT cord-010092-uftc8inx 6866 31 variety variety NN cord-010092-uftc8inx 6866 32 of of IN cord-010092-uftc8inx 6866 33 PDMPs pdmp NNS cord-010092-uftc8inx 6866 34 by by IN cord-010092-uftc8inx 6866 35 different different JJ cord-010092-uftc8inx 6866 36 and and CC cord-010092-uftc8inx 6866 37 complementary complementary JJ cord-010092-uftc8inx 6866 38 strategies strategy NNS cord-010092-uftc8inx 6866 39 consisting consist VBG cord-010092-uftc8inx 6866 40 in in IN cord-010092-uftc8inx 6866 41 maximizing maximize VBG cord-010092-uftc8inx 6866 42 the the DT cord-010092-uftc8inx 6866 43 yield yield NN cord-010092-uftc8inx 6866 44 and and CC cord-010092-uftc8inx 6866 45 the the DT cord-010092-uftc8inx 6866 46 portfolio portfolio NN cord-010092-uftc8inx 6866 47 of of IN cord-010092-uftc8inx 6866 48 proteins protein NNS cord-010092-uftc8inx 6866 49 from from IN cord-010092-uftc8inx 6866 50 the the DT cord-010092-uftc8inx 6866 51 fractionator fractionator NN cord-010092-uftc8inx 6866 52 and and CC cord-010092-uftc8inx 6866 53 exchanging exchange VBG cord-010092-uftc8inx 6866 54 products product NNS cord-010092-uftc8inx 6866 55 among among IN cord-010092-uftc8inx 6866 56 Regions region NNS cord-010092-uftc8inx 6866 57 for for IN cord-010092-uftc8inx 6866 58 other other JJ cord-010092-uftc8inx 6866 59 PDMPs pdmp NNS cord-010092-uftc8inx 6866 60 at at IN cord-010092-uftc8inx 6866 61 high high JJ cord-010092-uftc8inx 6866 62 demand demand NN cord-010092-uftc8inx 6866 63 but but CC cord-010092-uftc8inx 6866 64 not not RB cord-010092-uftc8inx 6866 65 included include VBN cord-010092-uftc8inx 6866 66 in in IN cord-010092-uftc8inx 6866 67 the the DT cord-010092-uftc8inx 6866 68 portfolio portfolio NN cord-010092-uftc8inx 6866 69 of of IN cord-010092-uftc8inx 6866 70 a a DT cord-010092-uftc8inx 6866 71 single single JJ cord-010092-uftc8inx 6866 72 fractionator fractionator NN cord-010092-uftc8inx 6866 73 . . . cord-010092-uftc8inx 6867 1 PLASMA plasma NN cord-010092-uftc8inx 6867 2 CHECK check NN cord-010092-uftc8inx 6867 3 SYSTEM system NN cord-010092-uftc8inx 6867 4 : : : cord-010092-uftc8inx 6868 1 A a DT cord-010092-uftc8inx 6868 2 VALUABLE valuable JJ cord-010092-uftc8inx 6868 3 TOOL tool NN cord-010092-uftc8inx 6868 4 FOR for IN cord-010092-uftc8inx 6868 5 PLASMA plasma NN cord-010092-uftc8inx 6868 6 FREEZING freezing NN cord-010092-uftc8inx 6868 7 VALIDATION validation NN cord-010092-uftc8inx 6868 8 AND and CC cord-010092-uftc8inx 6868 9 MONITORING monitoring NN cord-010092-uftc8inx 6868 10 . . . cord-010092-uftc8inx 6869 1 Background background NN cord-010092-uftc8inx 6869 2 : : : cord-010092-uftc8inx 6870 1 The the DT cord-010092-uftc8inx 6870 2 validation validation NN cord-010092-uftc8inx 6870 3 of of IN cord-010092-uftc8inx 6870 4 plasma plasma NN cord-010092-uftc8inx 6870 5 freezing freezing NN cord-010092-uftc8inx 6870 6 processes process NNS cord-010092-uftc8inx 6870 7 may may MD cord-010092-uftc8inx 6870 8 result result VB cord-010092-uftc8inx 6870 9 problematic problematic JJ cord-010092-uftc8inx 6870 10 in in IN cord-010092-uftc8inx 6870 11 the the DT cord-010092-uftc8inx 6870 12 monitoring monitoring NN cord-010092-uftc8inx 6870 13 / / SYM cord-010092-uftc8inx 6870 14 control control NN cord-010092-uftc8inx 6870 15 of of IN cord-010092-uftc8inx 6870 16 critical critical JJ cord-010092-uftc8inx 6870 17 process process NN cord-010092-uftc8inx 6870 18 parameters parameter NNS cord-010092-uftc8inx 6870 19 ( ( -LRB- cord-010092-uftc8inx 6870 20 CPP CPP NNP cord-010092-uftc8inx 6870 21 ) ) -RRB- cord-010092-uftc8inx 6870 22 . . . cord-010092-uftc8inx 6871 1 In in IN cord-010092-uftc8inx 6871 2 2017 2017 CD cord-010092-uftc8inx 6871 3 in in IN cord-010092-uftc8inx 6871 4 Italy Italy NNP cord-010092-uftc8inx 6871 5 923,944 923,944 CD cord-010092-uftc8inx 6871 6 litres litre NNS cord-010092-uftc8inx 6871 7 of of IN cord-010092-uftc8inx 6871 8 plasma plasma NN cord-010092-uftc8inx 6871 9 were be VBD cord-010092-uftc8inx 6871 10 produced produce VBN cord-010092-uftc8inx 6871 11 and and CC cord-010092-uftc8inx 6871 12 frozen freeze VBN cord-010092-uftc8inx 6871 13 . . . cord-010092-uftc8inx 6872 1 Aims aim VBZ cord-010092-uftc8inx 6872 2 : : : cord-010092-uftc8inx 6873 1 In in IN cord-010092-uftc8inx 6873 2 order order NN cord-010092-uftc8inx 6873 3 to to TO cord-010092-uftc8inx 6873 4 assist assist VB cord-010092-uftc8inx 6873 5 plasma plasma NN cord-010092-uftc8inx 6873 6 freezing freeze VBG cord-010092-uftc8inx 6873 7 validation validation NN cord-010092-uftc8inx 6873 8 and and CC cord-010092-uftc8inx 6873 9 CPP CPP NNP cord-010092-uftc8inx 6873 10 monitoring monitoring NN cord-010092-uftc8inx 6873 11 , , , cord-010092-uftc8inx 6873 12 151 151 CD cord-010092-uftc8inx 6873 13 of of IN cord-010092-uftc8inx 6873 14 the the DT cord-010092-uftc8inx 6873 15 176 176 CD cord-010092-uftc8inx 6873 16 Italian italian JJ cord-010092-uftc8inx 6873 17 BEs be NNS cord-010092-uftc8inx 6873 18 performing perform VBG cord-010092-uftc8inx 6873 19 plasma plasma NN cord-010092-uftc8inx 6873 20 freezing freezing NN cord-010092-uftc8inx 6873 21 utilize utilize VBP cord-010092-uftc8inx 6873 22 the the DT cord-010092-uftc8inx 6873 23 Plasma Plasma NNP cord-010092-uftc8inx 6873 24 Check check NN cord-010092-uftc8inx 6873 25 System System NNP cord-010092-uftc8inx 6873 26 ( ( -LRB- cord-010092-uftc8inx 6873 27 PCS PCS NNP cord-010092-uftc8inx 6873 28 ) ) -RRB- cord-010092-uftc8inx 6873 29 , , , cord-010092-uftc8inx 6873 30 a a DT cord-010092-uftc8inx 6873 31 system system NN cord-010092-uftc8inx 6873 32 able able JJ cord-010092-uftc8inx 6873 33 to to TO cord-010092-uftc8inx 6873 34 record record VB cord-010092-uftc8inx 6873 35 , , , cord-010092-uftc8inx 6873 36 store store VB cord-010092-uftc8inx 6873 37 and and CC cord-010092-uftc8inx 6873 38 certify certify VB cord-010092-uftc8inx 6873 39 the the DT cord-010092-uftc8inx 6873 40 temperature temperature NN cord-010092-uftc8inx 6873 41 ( ( -LRB- cord-010092-uftc8inx 6873 42 T t NN cord-010092-uftc8inx 6873 43 ) ) -RRB- cord-010092-uftc8inx 6873 44 detected detect VBD cord-010092-uftc8inx 6873 45 at at IN cord-010092-uftc8inx 6873 46 the the DT cord-010092-uftc8inx 6873 47 core core NN cord-010092-uftc8inx 6873 48 of of IN cord-010092-uftc8inx 6873 49 " " `` cord-010092-uftc8inx 6873 50 surrogate surrogate JJ cord-010092-uftc8inx 6873 51 " " '' cord-010092-uftc8inx 6873 52 bags bag NNS cord-010092-uftc8inx 6873 53 during during IN cord-010092-uftc8inx 6873 54 the the DT cord-010092-uftc8inx 6873 55 entire entire JJ cord-010092-uftc8inx 6873 56 freezing freezing NN cord-010092-uftc8inx 6873 57 session session NN cord-010092-uftc8inx 6873 58 , , , cord-010092-uftc8inx 6873 59 consistently consistently RB cord-010092-uftc8inx 6873 60 with with IN cord-010092-uftc8inx 6873 61 GMP GMP NNP cord-010092-uftc8inx 6873 62 requirements requirement NNS cord-010092-uftc8inx 6873 63 . . . cord-010092-uftc8inx 6874 1 PCS PCS NNP cord-010092-uftc8inx 6874 2 is be VBZ cord-010092-uftc8inx 6874 3 patented patent VBN cord-010092-uftc8inx 6874 4 and and CC cord-010092-uftc8inx 6874 5 commercialized commercialize VBN cord-010092-uftc8inx 6874 6 by by IN cord-010092-uftc8inx 6874 7 Expertmed Expertmed NNP cord-010092-uftc8inx 6874 8 Srl Srl NNP cord-010092-uftc8inx 6874 9 , , , cord-010092-uftc8inx 6874 10 Verona Verona NNP cord-010092-uftc8inx 6874 11 , , , cord-010092-uftc8inx 6874 12 Italy Italy NNP cord-010092-uftc8inx 6874 13 ( ( -LRB- cord-010092-uftc8inx 6874 14 http://www.expertmed.it http://www.expertmed.it NNP cord-010092-uftc8inx 6874 15 ) ) -RRB- cord-010092-uftc8inx 6874 16 . . . cord-010092-uftc8inx 6875 1 Methods method NNS cord-010092-uftc8inx 6875 2 : : : cord-010092-uftc8inx 6875 3 PCS PCS NNP cord-010092-uftc8inx 6875 4 consists consist VBZ cord-010092-uftc8inx 6875 5 of of IN cord-010092-uftc8inx 6875 6 3 3 CD cord-010092-uftc8inx 6875 7 parts part NNS cord-010092-uftc8inx 6875 8 : : : cord-010092-uftc8inx 6875 9 a a LS cord-010092-uftc8inx 6875 10 ) ) -RRB- cord-010092-uftc8inx 6875 11 " " `` cord-010092-uftc8inx 6875 12 surrogate surrogate JJ cord-010092-uftc8inx 6875 13 " " '' cord-010092-uftc8inx 6875 14 bags bag NNS cord-010092-uftc8inx 6875 15 ( ( -LRB- cord-010092-uftc8inx 6875 16 Check check NN cord-010092-uftc8inx 6875 17 - - HYPH cord-010092-uftc8inx 6875 18 bags bag NNS cord-010092-uftc8inx 6875 19 ) ) -RRB- cord-010092-uftc8inx 6875 20 of of IN cord-010092-uftc8inx 6875 21 250 250 CD cord-010092-uftc8inx 6875 22 and and CC cord-010092-uftc8inx 6875 23 700 700 CD cord-010092-uftc8inx 6875 24 mL ml NN cord-010092-uftc8inx 6875 25 corresponding correspond VBG cord-010092-uftc8inx 6875 26 to to IN cord-010092-uftc8inx 6875 27 the the DT cord-010092-uftc8inx 6875 28 average average JJ cord-010092-uftc8inx 6875 29 standard standard JJ cord-010092-uftc8inx 6875 30 volumes volume NNS cord-010092-uftc8inx 6875 31 of of IN cord-010092-uftc8inx 6875 32 the the DT cord-010092-uftc8inx 6875 33 real real JJ cord-010092-uftc8inx 6875 34 products product NNS cord-010092-uftc8inx 6875 35 , , , cord-010092-uftc8inx 6875 36 containing contain VBG cord-010092-uftc8inx 6875 37 a a DT cord-010092-uftc8inx 6875 38 fluid fluid NN cord-010092-uftc8inx 6875 39 validated validate VBN cord-010092-uftc8inx 6875 40 to to TO cord-010092-uftc8inx 6875 41 simulate simulate VB cord-010092-uftc8inx 6875 42 the the DT cord-010092-uftc8inx 6875 43 thermal thermal JJ cord-010092-uftc8inx 6875 44 behaviour behaviour NN cord-010092-uftc8inx 6875 45 of of IN cord-010092-uftc8inx 6875 46 plasma plasma NN cord-010092-uftc8inx 6875 47 ; ; : cord-010092-uftc8inx 6875 48 b b LS cord-010092-uftc8inx 6875 49 ) ) -RRB- cord-010092-uftc8inx 6875 50 a a DT cord-010092-uftc8inx 6875 51 mobile mobile JJ cord-010092-uftc8inx 6875 52 probe probe NN cord-010092-uftc8inx 6875 53 ( ( -LRB- cord-010092-uftc8inx 6875 54 Cryo Cryo NNP cord-010092-uftc8inx 6875 55 - - HYPH cord-010092-uftc8inx 6875 56 Med Med NNP cord-010092-uftc8inx 6875 57 ) ) -RRB- cord-010092-uftc8inx 6875 58 positionable positionable JJ cord-010092-uftc8inx 6875 59 at at IN cord-010092-uftc8inx 6875 60 the the DT cord-010092-uftc8inx 6875 61 core core NN cord-010092-uftc8inx 6875 62 of of IN cord-010092-uftc8inx 6875 63 the the DT cord-010092-uftc8inx 6875 64 Check check NN cord-010092-uftc8inx 6875 65 - - HYPH cord-010092-uftc8inx 6875 66 bags bag NNS cord-010092-uftc8inx 6875 67 ; ; : cord-010092-uftc8inx 6875 68 c c LS cord-010092-uftc8inx 6875 69 ) ) -RRB- cord-010092-uftc8inx 6875 70 a a DT cord-010092-uftc8inx 6875 71 dedicated dedicated JJ cord-010092-uftc8inx 6875 72 software software NN cord-010092-uftc8inx 6875 73 ( ( -LRB- cord-010092-uftc8inx 6875 74 Memo Memo NNP cord-010092-uftc8inx 6875 75 - - HYPH cord-010092-uftc8inx 6875 76 Track Track NNP cord-010092-uftc8inx 6875 77 ) ) -RRB- cord-010092-uftc8inx 6875 78 . . . cord-010092-uftc8inx 6876 1 Plasma plasma NN cord-010092-uftc8inx 6876 2 freezing freezing JJ cord-010092-uftc8inx 6876 3 session session NN cord-010092-uftc8inx 6876 4 data datum NNS cord-010092-uftc8inx 6876 5 are be VBP cord-010092-uftc8inx 6876 6 tracked track VBN cord-010092-uftc8inx 6876 7 via via IN cord-010092-uftc8inx 6876 8 barcode barcode NNP cord-010092-uftc8inx 6876 9 / / SYM cord-010092-uftc8inx 6876 10 RFID RFID NNP cord-010092-uftc8inx 6876 11 and and CC cord-010092-uftc8inx 6876 12 can can MD cord-010092-uftc8inx 6876 13 be be VB cord-010092-uftc8inx 6876 14 consulted consult VBN cord-010092-uftc8inx 6876 15 by by IN cord-010092-uftc8inx 6876 16 the the DT cord-010092-uftc8inx 6876 17 PCS PCS NNP cord-010092-uftc8inx 6876 18 that that WDT cord-010092-uftc8inx 6876 19 associates associate NNS cord-010092-uftc8inx 6876 20 blast blast VBP cord-010092-uftc8inx 6876 21 freezer freezer NNP cord-010092-uftc8inx 6876 22 code code NN cord-010092-uftc8inx 6876 23 , , , cord-010092-uftc8inx 6876 24 operator operator NN cord-010092-uftc8inx 6876 25 code code NN cord-010092-uftc8inx 6876 26 , , , cord-010092-uftc8inx 6876 27 Cryo Cryo NNP cord-010092-uftc8inx 6876 28 - - HYPH cord-010092-uftc8inx 6876 29 Med Med NNP cord-010092-uftc8inx 6876 30 and and CC cord-010092-uftc8inx 6876 31 Check check NN cord-010092-uftc8inx 6876 32 - - HYPH cord-010092-uftc8inx 6876 33 bag bag NN cord-010092-uftc8inx 6876 34 . . . cord-010092-uftc8inx 6877 1 Data datum NNS cord-010092-uftc8inx 6877 2 on on IN cord-010092-uftc8inx 6877 3 plasma plasma NN cord-010092-uftc8inx 6877 4 freezing freezing NN cord-010092-uftc8inx 6877 5 are be VBP cord-010092-uftc8inx 6877 6 stored store VBN cord-010092-uftc8inx 6877 7 in in IN cord-010092-uftc8inx 6877 8 a a DT cord-010092-uftc8inx 6877 9 shared share VBN cord-010092-uftc8inx 6877 10 folder folder NN cord-010092-uftc8inx 6877 11 and and CC cord-010092-uftc8inx 6877 12 transferred transfer VBN cord-010092-uftc8inx 6877 13 to to IN cord-010092-uftc8inx 6877 14 the the DT cord-010092-uftc8inx 6877 15 BE BE NNP cord-010092-uftc8inx 6877 16 information information NN cord-010092-uftc8inx 6877 17 system system NN cord-010092-uftc8inx 6877 18 . . . cord-010092-uftc8inx 6878 1 The the DT cord-010092-uftc8inx 6878 2 PCS PCS NNP cord-010092-uftc8inx 6878 3 can can MD cord-010092-uftc8inx 6878 4 also also RB cord-010092-uftc8inx 6878 5 be be VB cord-010092-uftc8inx 6878 6 used use VBN cord-010092-uftc8inx 6878 7 to to TO cord-010092-uftc8inx 6878 8 check check VB cord-010092-uftc8inx 6878 9 and and CC cord-010092-uftc8inx 6878 10 monitor monitor VB cord-010092-uftc8inx 6878 11 the the DT cord-010092-uftc8inx 6878 12 out out RP cord-010092-uftc8inx 6878 13 - - HYPH cord-010092-uftc8inx 6878 14 of of IN cord-010092-uftc8inx 6878 15 - - HYPH cord-010092-uftc8inx 6878 16 storage storage NN cord-010092-uftc8inx 6878 17 variations variation NNS cord-010092-uftc8inx 6878 18 of of IN cord-010092-uftc8inx 6878 19 core core NN cord-010092-uftc8inx 6878 20 T t NN cord-010092-uftc8inx 6878 21 of of IN cord-010092-uftc8inx 6878 22 frozen frozen JJ cord-010092-uftc8inx 6878 23 plasma plasma NN cord-010092-uftc8inx 6878 24 unit unit NN cord-010092-uftc8inx 6878 25 , , , cord-010092-uftc8inx 6878 26 i.e. i.e. FW cord-010092-uftc8inx 6878 27 during during IN cord-010092-uftc8inx 6878 28 labelling labelling NN cord-010092-uftc8inx 6878 29 and and CC cord-010092-uftc8inx 6878 30 packaging packaging NN cord-010092-uftc8inx 6878 31 procedures procedure NNS cord-010092-uftc8inx 6878 32 , , , cord-010092-uftc8inx 6878 33 thus thus RB cord-010092-uftc8inx 6878 34 allowing allow VBG cord-010092-uftc8inx 6878 35 to to TO cord-010092-uftc8inx 6878 36 establish establish VB cord-010092-uftc8inx 6878 37 optimal optimal JJ cord-010092-uftc8inx 6878 38 timeframes timeframe NNS cord-010092-uftc8inx 6878 39 and and CC cord-010092-uftc8inx 6878 40 operations operation NNS cord-010092-uftc8inx 6878 41 and and CC cord-010092-uftc8inx 6878 42 suitably suitably RB cord-010092-uftc8inx 6878 43 validate validate VB cord-010092-uftc8inx 6878 44 these these DT cord-010092-uftc8inx 6878 45 procedures procedure NNS cord-010092-uftc8inx 6878 46 . . . cord-010092-uftc8inx 6879 1 In in IN cord-010092-uftc8inx 6879 2 the the DT cord-010092-uftc8inx 6879 3 period period NN cord-010092-uftc8inx 6879 4 2016 2016 CD cord-010092-uftc8inx 6879 5 - - SYM cord-010092-uftc8inx 6879 6 2018 2018 CD cord-010092-uftc8inx 6879 7 , , , cord-010092-uftc8inx 6879 8 at at IN cord-010092-uftc8inx 6879 9 the the DT cord-010092-uftc8inx 6879 10 Pievesestina Pievesestina NNP cord-010092-uftc8inx 6879 11 BE BE NNP cord-010092-uftc8inx 6879 12 of of IN cord-010092-uftc8inx 6879 13 Emilia Emilia NNP cord-010092-uftc8inx 6879 14 Romagna Romagna NNP cord-010092-uftc8inx 6879 15 region region NN cord-010092-uftc8inx 6879 16 210,871 210,871 CD cord-010092-uftc8inx 6879 17 plasma plasma NN cord-010092-uftc8inx 6879 18 units unit NNS cord-010092-uftc8inx 6879 19 were be VBD cord-010092-uftc8inx 6879 20 frozen freeze VBN cord-010092-uftc8inx 6879 21 so so IN cord-010092-uftc8inx 6879 22 as as IN cord-010092-uftc8inx 6879 23 to to TO cord-010092-uftc8inx 6879 24 allow allow VB cord-010092-uftc8inx 6879 25 complete complete JJ cord-010092-uftc8inx 6879 26 freezing freezing NN cord-010092-uftc8inx 6879 27 within within IN cord-010092-uftc8inx 6879 28 60 60 CD cord-010092-uftc8inx 6879 29 0 0 CD cord-010092-uftc8inx 6879 30 to to IN cord-010092-uftc8inx 6879 31 a a DT cord-010092-uftc8inx 6879 32 temperature temperature NN cord-010092-uftc8inx 6879 33 below below IN cord-010092-uftc8inx 6879 34 À30 À30 NNP cord-010092-uftc8inx 6879 35 ° ° NN cord-010092-uftc8inx 6879 36 C C NNP cord-010092-uftc8inx 6879 37 , , , cord-010092-uftc8inx 6879 38 in in IN cord-010092-uftc8inx 6879 39 8,349 8,349 CD cord-010092-uftc8inx 6879 40 freezing freezing JJ cord-010092-uftc8inx 6879 41 sessions session NNS cord-010092-uftc8inx 6879 42 , , , cord-010092-uftc8inx 6879 43 using use VBG cord-010092-uftc8inx 6879 44 the the DT cord-010092-uftc8inx 6879 45 PCS PCS NNP cord-010092-uftc8inx 6879 46 both both DT cord-010092-uftc8inx 6879 47 for for IN cord-010092-uftc8inx 6879 48 process process NN cord-010092-uftc8inx 6879 49 validation validation NN cord-010092-uftc8inx 6879 50 , , , cord-010092-uftc8inx 6879 51 change change VB cord-010092-uftc8inx 6879 52 control control NN cord-010092-uftc8inx 6879 53 and and CC cord-010092-uftc8inx 6879 54 for for IN cord-010092-uftc8inx 6879 55 the the DT cord-010092-uftc8inx 6879 56 systematic systematic JJ cord-010092-uftc8inx 6879 57 monitoring monitoring NN cord-010092-uftc8inx 6879 58 of of IN cord-010092-uftc8inx 6879 59 core core NN cord-010092-uftc8inx 6879 60 T t NN cord-010092-uftc8inx 6879 61 at at IN cord-010092-uftc8inx 6879 62 each each DT cord-010092-uftc8inx 6879 63 freezing freezing JJ cord-010092-uftc8inx 6879 64 session session NN cord-010092-uftc8inx 6879 65 . . . cord-010092-uftc8inx 6880 1 Furthermore furthermore RB cord-010092-uftc8inx 6880 2 , , , cord-010092-uftc8inx 6880 3 at at IN cord-010092-uftc8inx 6880 4 the the DT cord-010092-uftc8inx 6880 5 Bologna Bologna NNP cord-010092-uftc8inx 6880 6 BE be VB cord-010092-uftc8inx 6880 7 108 108 CD cord-010092-uftc8inx 6880 8 tests test NNS cord-010092-uftc8inx 6880 9 on on IN cord-010092-uftc8inx 6880 10 the the DT cord-010092-uftc8inx 6880 11 out out JJ cord-010092-uftc8inx 6880 12 - - HYPH cord-010092-uftc8inx 6880 13 of of IN cord-010092-uftc8inx 6880 14 - - HYPH cord-010092-uftc8inx 6880 15 storage storage NN cord-010092-uftc8inx 6880 16 conditions condition NNS cord-010092-uftc8inx 6880 17 of of IN cord-010092-uftc8inx 6880 18 plasma plasma NN cord-010092-uftc8inx 6880 19 units unit NNS cord-010092-uftc8inx 6880 20 were be VBD cord-010092-uftc8inx 6880 21 carried carry VBN cord-010092-uftc8inx 6880 22 out out RP cord-010092-uftc8inx 6880 23 to to TO cord-010092-uftc8inx 6880 24 revalidate revalidate VB cord-010092-uftc8inx 6880 25 the the DT cord-010092-uftc8inx 6880 26 procedures procedure NNS cord-010092-uftc8inx 6880 27 of of IN cord-010092-uftc8inx 6880 28 labelling labelling NN cord-010092-uftc8inx 6880 29 and and CC cord-010092-uftc8inx 6880 30 packaging packaging NN cord-010092-uftc8inx 6880 31 . . . cord-010092-uftc8inx 6881 1 Results result NNS cord-010092-uftc8inx 6881 2 : : : cord-010092-uftc8inx 6882 1 Out out IN cord-010092-uftc8inx 6882 2 of of IN cord-010092-uftc8inx 6882 3 8,349 8,349 CD cord-010092-uftc8inx 6882 4 freezing freezing NN cord-010092-uftc8inx 6882 5 sessions session NNS cord-010092-uftc8inx 6882 6 carried carry VBN cord-010092-uftc8inx 6882 7 out out RP cord-010092-uftc8inx 6882 8 at at IN cord-010092-uftc8inx 6882 9 the the DT cord-010092-uftc8inx 6882 10 Pievesestina Pievesestina NNP cord-010092-uftc8inx 6882 11 BE BE NNP cord-010092-uftc8inx 6882 12 , , , cord-010092-uftc8inx 6882 13 27 27 CD cord-010092-uftc8inx 6882 14 ( ( -LRB- cord-010092-uftc8inx 6882 15 0.3 0.3 CD cord-010092-uftc8inx 6882 16 % % NN cord-010092-uftc8inx 6882 17 ) ) -RRB- cord-010092-uftc8inx 6882 18 were be VBD cord-010092-uftc8inx 6882 19 detected detect VBN cord-010092-uftc8inx 6882 20 to to TO cord-010092-uftc8inx 6882 21 fail fail VB cord-010092-uftc8inx 6882 22 to to TO cord-010092-uftc8inx 6882 23 reach reach VB cord-010092-uftc8inx 6882 24 À30 À30 NNP cord-010092-uftc8inx 6882 25 ° ° NN cord-010092-uftc8inx 6882 26 C c NN cord-010092-uftc8inx 6882 27 at at IN cord-010092-uftc8inx 6882 28 the the DT cord-010092-uftc8inx 6882 29 core core NN cord-010092-uftc8inx 6882 30 of of IN cord-010092-uftc8inx 6882 31 the the DT cord-010092-uftc8inx 6882 32 Check check NN cord-010092-uftc8inx 6882 33 - - HYPH cord-010092-uftc8inx 6882 34 bags bag NNS cord-010092-uftc8inx 6882 35 within within IN cord-010092-uftc8inx 6882 36 60 60 CD cord-010092-uftc8inx 6882 37 0 0 CD cord-010092-uftc8inx 6882 38 . . . cord-010092-uftc8inx 6883 1 Of of IN cord-010092-uftc8inx 6883 2 the the DT cord-010092-uftc8inx 6883 3 latter latter JJ cord-010092-uftc8inx 6883 4 , , , cord-010092-uftc8inx 6883 5 in in IN cord-010092-uftc8inx 6883 6 most most JJS cord-010092-uftc8inx 6883 7 cases case NNS cord-010092-uftc8inx 6883 8 ( ( -LRB- cord-010092-uftc8inx 6883 9 70 70 CD cord-010092-uftc8inx 6883 10 % % NN cord-010092-uftc8inx 6883 11 ) ) -RRB- cord-010092-uftc8inx 6883 12 a a DT cord-010092-uftc8inx 6883 13 technical technical JJ cord-010092-uftc8inx 6883 14 error error NN cord-010092-uftc8inx 6883 15 in in IN cord-010092-uftc8inx 6883 16 the the DT cord-010092-uftc8inx 6883 17 activation activation NN cord-010092-uftc8inx 6883 18 of of IN cord-010092-uftc8inx 6883 19 the the DT cord-010092-uftc8inx 6883 20 Cryo Cryo NNP cord-010092-uftc8inx 6883 21 - - HYPH cord-010092-uftc8inx 6883 22 Med Med NNP cord-010092-uftc8inx 6883 23 was be VBD cord-010092-uftc8inx 6883 24 identified identify VBN cord-010092-uftc8inx 6883 25 . . . cord-010092-uftc8inx 6884 1 In in IN cord-010092-uftc8inx 6884 2 addition addition NN cord-010092-uftc8inx 6884 3 , , , cord-010092-uftc8inx 6884 4 the the DT cord-010092-uftc8inx 6884 5 PCS PCS NNP cord-010092-uftc8inx 6884 6 was be VBD cord-010092-uftc8inx 6884 7 systematically systematically RB cord-010092-uftc8inx 6884 8 utilized utilize VBN cord-010092-uftc8inx 6884 9 for for IN cord-010092-uftc8inx 6884 10 periodical periodical JJ cord-010092-uftc8inx 6884 11 revalidation revalidation NN cord-010092-uftc8inx 6884 12 of of IN cord-010092-uftc8inx 6884 13 the the DT cord-010092-uftc8inx 6884 14 freezing freeze VBG cord-010092-uftc8inx 6884 15 procedures procedure NNS cord-010092-uftc8inx 6884 16 . . . cord-010092-uftc8inx 6885 1 The the DT cord-010092-uftc8inx 6885 2 tests test NNS cord-010092-uftc8inx 6885 3 performed perform VBN cord-010092-uftc8inx 6885 4 at at IN cord-010092-uftc8inx 6885 5 the the DT cord-010092-uftc8inx 6885 6 Bologna Bologna NNP cord-010092-uftc8inx 6885 7 BE be VB cord-010092-uftc8inx 6885 8 to to TO cord-010092-uftc8inx 6885 9 validate validate VB cord-010092-uftc8inx 6885 10 the the DT cord-010092-uftc8inx 6885 11 out out RB cord-010092-uftc8inx 6885 12 - - HYPH cord-010092-uftc8inx 6885 13 of of IN cord-010092-uftc8inx 6885 14 - - HYPH cord-010092-uftc8inx 6885 15 storage storage NN cord-010092-uftc8inx 6885 16 procedures procedure NNS cord-010092-uftc8inx 6885 17 of of IN cord-010092-uftc8inx 6885 18 frozen frozen JJ cord-010092-uftc8inx 6885 19 plasma plasma NN cord-010092-uftc8inx 6885 20 labelling labelling NN cord-010092-uftc8inx 6885 21 and and CC cord-010092-uftc8inx 6885 22 packaging packaging NN cord-010092-uftc8inx 6885 23 allowed allow VBN cord-010092-uftc8inx 6885 24 to to TO cord-010092-uftc8inx 6885 25 modify modify VB cord-010092-uftc8inx 6885 26 the the DT cord-010092-uftc8inx 6885 27 operating operating NN cord-010092-uftc8inx 6885 28 procedures procedure NNS cord-010092-uftc8inx 6885 29 in in IN cord-010092-uftc8inx 6885 30 place place NN cord-010092-uftc8inx 6885 31 so so IN cord-010092-uftc8inx 6885 32 as as IN cord-010092-uftc8inx 6885 33 to to TO cord-010092-uftc8inx 6885 34 establish establish VB cord-010092-uftc8inx 6885 35 optimal optimal JJ cord-010092-uftc8inx 6885 36 timeframes timeframe NNS cord-010092-uftc8inx 6885 37 and and CC cord-010092-uftc8inx 6885 38 operations operation NNS cord-010092-uftc8inx 6885 39 . . . cord-010092-uftc8inx 6886 1 This this DT cord-010092-uftc8inx 6886 2 prompted prompt VBD cord-010092-uftc8inx 6886 3 corrective corrective JJ cord-010092-uftc8inx 6886 4 actions action NNS cord-010092-uftc8inx 6886 5 regarding regard VBG cord-010092-uftc8inx 6886 6 : : : cord-010092-uftc8inx 6887 1 i i PRP cord-010092-uftc8inx 6887 2 ) ) -RRB- cord-010092-uftc8inx 6887 3 number number NN cord-010092-uftc8inx 6887 4 of of IN cord-010092-uftc8inx 6887 5 units unit NNS cord-010092-uftc8inx 6887 6 to to TO cord-010092-uftc8inx 6887 7 be be VB cord-010092-uftc8inx 6887 8 taken take VBN cord-010092-uftc8inx 6887 9 out out IN cord-010092-uftc8inx 6887 10 of of IN cord-010092-uftc8inx 6887 11 storage storage NN cord-010092-uftc8inx 6887 12 sites site NNS cord-010092-uftc8inx 6887 13 at at IN cord-010092-uftc8inx 6887 14 each each DT cord-010092-uftc8inx 6887 15 labelling labelling NN cord-010092-uftc8inx 6887 16 session session NN cord-010092-uftc8inx 6887 17 ( ( -LRB- cord-010092-uftc8inx 6887 18 < < XX cord-010092-uftc8inx 6887 19 24 24 CD cord-010092-uftc8inx 6887 20 units unit NNS cord-010092-uftc8inx 6887 21 ) ) -RRB- cord-010092-uftc8inx 6887 22 , , , cord-010092-uftc8inx 6887 23 ii ii LS cord-010092-uftc8inx 6887 24 ) ) -RRB- cord-010092-uftc8inx 6887 25 labelling labelling NN cord-010092-uftc8inx 6887 26 time time NN cord-010092-uftc8inx 6888 1 ( ( -LRB- cord-010092-uftc8inx 6888 2 < < NNP cord-010092-uftc8inx 6888 3 8 8 CD cord-010092-uftc8inx 6888 4 0 0 CD cord-010092-uftc8inx 6888 5 ) ) -RRB- cord-010092-uftc8inx 6888 6 , , , cord-010092-uftc8inx 6888 7 iii iii LS cord-010092-uftc8inx 6888 8 ) ) -RRB- cord-010092-uftc8inx 6888 9 optimal optimal JJ cord-010092-uftc8inx 6888 10 storage storage NN cord-010092-uftc8inx 6888 11 T T NNP cord-010092-uftc8inx 6888 12 ( ( -LRB- cord-010092-uftc8inx 6888 13 À40 À40 NNP cord-010092-uftc8inx 6888 14 ° ° NN cord-010092-uftc8inx 6888 15 C c NN cord-010092-uftc8inx 6888 16 vs. vs. IN cord-010092-uftc8inx 6888 17 À30 À30 NNP cord-010092-uftc8inx 6888 18 ° ° NN cord-010092-uftc8inx 6888 19 C C NNP cord-010092-uftc8inx 6888 20 ) ) -RRB- cord-010092-uftc8inx 6888 21 , , , cord-010092-uftc8inx 6888 22 iv iv LS cord-010092-uftc8inx 6888 23 ) ) -RRB- cord-010092-uftc8inx 6888 24 optimal optimal JJ cord-010092-uftc8inx 6888 25 time time NN cord-010092-uftc8inx 6888 26 between between IN cord-010092-uftc8inx 6888 27 two two CD cord-010092-uftc8inx 6888 28 openings opening NNS cord-010092-uftc8inx 6888 29 of of IN cord-010092-uftc8inx 6888 30 storage storage NN cord-010092-uftc8inx 6888 31 sites site NNS cord-010092-uftc8inx 6888 32 ( ( -LRB- cord-010092-uftc8inx 6888 33 > > NFP cord-010092-uftc8inx 6888 34 30 30 CD cord-010092-uftc8inx 6888 35 0 0 CD cord-010092-uftc8inx 6888 36 ) ) -RRB- cord-010092-uftc8inx 6888 37 . . . cord-010092-uftc8inx 6889 1 Summary Summary NNP cord-010092-uftc8inx 6889 2 / / SYM cord-010092-uftc8inx 6889 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 6889 4 : : : cord-010092-uftc8inx 6890 1 The the DT cord-010092-uftc8inx 6890 2 PCS PCS NNP cord-010092-uftc8inx 6890 3 is be VBZ cord-010092-uftc8inx 6890 4 a a DT cord-010092-uftc8inx 6890 5 valuable valuable JJ cord-010092-uftc8inx 6890 6 system system NN cord-010092-uftc8inx 6890 7 for for IN cord-010092-uftc8inx 6890 8 plasma plasma NN cord-010092-uftc8inx 6890 9 freezing freeze VBG cord-010092-uftc8inx 6890 10 validation validation NN cord-010092-uftc8inx 6890 11 and and CC cord-010092-uftc8inx 6890 12 monitoring monitoring NN cord-010092-uftc8inx 6890 13 , , , cord-010092-uftc8inx 6890 14 as as RB cord-010092-uftc8inx 6890 15 well well RB cord-010092-uftc8inx 6890 16 as as IN cord-010092-uftc8inx 6890 17 to to TO cord-010092-uftc8inx 6890 18 perform perform VB cord-010092-uftc8inx 6890 19 monitoring monitoring NN cord-010092-uftc8inx 6890 20 and and CC cord-010092-uftc8inx 6890 21 control control NN cord-010092-uftc8inx 6890 22 of of IN cord-010092-uftc8inx 6890 23 the the DT cord-010092-uftc8inx 6890 24 whole whole JJ cord-010092-uftc8inx 6890 25 pathway pathway NN cord-010092-uftc8inx 6890 26 of of IN cord-010092-uftc8inx 6890 27 frozen frozen JJ cord-010092-uftc8inx 6890 28 plasma plasma NN cord-010092-uftc8inx 6890 29 in in IN cord-010092-uftc8inx 6890 30 the the DT cord-010092-uftc8inx 6890 31 BE be NN cord-010092-uftc8inx 6890 32 . . . cord-010092-uftc8inx 6891 1 It -PRON- PRP cord-010092-uftc8inx 6891 2 is be VBZ cord-010092-uftc8inx 6891 3 a a DT cord-010092-uftc8inx 6891 4 technologically technologically RB cord-010092-uftc8inx 6891 5 advanced advanced JJ cord-010092-uftc8inx 6891 6 , , , cord-010092-uftc8inx 6891 7 easy easy JJ cord-010092-uftc8inx 6891 8 - - HYPH cord-010092-uftc8inx 6891 9 to to IN cord-010092-uftc8inx 6891 10 - - HYPH cord-010092-uftc8inx 6891 11 use use NN cord-010092-uftc8inx 6891 12 and and CC cord-010092-uftc8inx 6891 13 costeffective costeffective JJ cord-010092-uftc8inx 6891 14 tool tool NN cord-010092-uftc8inx 6891 15 that that WDT cord-010092-uftc8inx 6891 16 can can MD cord-010092-uftc8inx 6891 17 efficiently efficiently RB cord-010092-uftc8inx 6891 18 replace replace VB cord-010092-uftc8inx 6891 19 other other JJ cord-010092-uftc8inx 6891 20 traditional traditional JJ cord-010092-uftc8inx 6891 21 methods method NNS cord-010092-uftc8inx 6891 22 commonly commonly RB cord-010092-uftc8inx 6891 23 used use VBN cord-010092-uftc8inx 6891 24 for for IN cord-010092-uftc8inx 6891 25 the the DT cord-010092-uftc8inx 6891 26 above above RB cord-010092-uftc8inx 6891 27 - - HYPH cord-010092-uftc8inx 6891 28 mentioned mention VBN cord-010092-uftc8inx 6891 29 purposes purpose NNS cord-010092-uftc8inx 6891 30 . . . cord-010092-uftc8inx 6892 1 ASSESSMENT ASSESSMENT NNP cord-010092-uftc8inx 6892 2 OF of IN cord-010092-uftc8inx 6892 3 BLOOD blood NN cord-010092-uftc8inx 6892 4 GROUP group NN cord-010092-uftc8inx 6892 5 MATCHING matching NN cord-010092-uftc8inx 6892 6 QUALITY quality NN cord-010092-uftc8inx 6892 7 USING use VBG cord-010092-uftc8inx 6892 8 SIX six CD cord-010092-uftc8inx 6892 9 SIGMA SIGMA NNP cord-010092-uftc8inx 6892 10 METRICS METRICS NNP cord-010092-uftc8inx 6892 11 Background Background NNP cord-010092-uftc8inx 6892 12 : : : cord-010092-uftc8inx 6893 1 Six six CD cord-010092-uftc8inx 6893 2 - - HYPH cord-010092-uftc8inx 6893 3 sigma sigma NN cord-010092-uftc8inx 6893 4 metrics metric NNS cord-010092-uftc8inx 6893 5 provides provide VBZ cord-010092-uftc8inx 6893 6 a a DT cord-010092-uftc8inx 6893 7 general general JJ cord-010092-uftc8inx 6893 8 methodology methodology NN cord-010092-uftc8inx 6893 9 to to TO cord-010092-uftc8inx 6893 10 evaluate evaluate VB cord-010092-uftc8inx 6893 11 a a DT cord-010092-uftc8inx 6893 12 process process NN cord-010092-uftc8inx 6893 13 performance performance NN cord-010092-uftc8inx 6893 14 on on IN cord-010092-uftc8inx 6893 15 a a DT cord-010092-uftc8inx 6893 16 sigma sigma NN cord-010092-uftc8inx 6893 17 scale scale NN cord-010092-uftc8inx 6893 18 . . . cord-010092-uftc8inx 6894 1 Implementation implementation NN cord-010092-uftc8inx 6894 2 of of IN cord-010092-uftc8inx 6894 3 Six Six NNP cord-010092-uftc8inx 6894 4 - - HYPH cord-010092-uftc8inx 6894 5 sigma sigma NNP cord-010092-uftc8inx 6894 6 for for IN cord-010092-uftc8inx 6894 7 quality quality NN cord-010092-uftc8inx 6894 8 assurance assurance NN cord-010092-uftc8inx 6894 9 can can MD cord-010092-uftc8inx 6894 10 benefit benefit VB cord-010092-uftc8inx 6894 11 the the DT cord-010092-uftc8inx 6894 12 health health NN cord-010092-uftc8inx 6894 13 care care NN cord-010092-uftc8inx 6894 14 sectors sector NNS cord-010092-uftc8inx 6894 15 . . . cord-010092-uftc8inx 6895 1 One one CD cord-010092-uftc8inx 6895 2 of of IN cord-010092-uftc8inx 6895 3 the the DT cord-010092-uftc8inx 6895 4 most most RBS cord-010092-uftc8inx 6895 5 important important JJ cord-010092-uftc8inx 6895 6 health health NN cord-010092-uftc8inx 6895 7 care care NN cord-010092-uftc8inx 6895 8 sectors sector NNS cord-010092-uftc8inx 6895 9 is be VBZ cord-010092-uftc8inx 6895 10 blood blood NN cord-010092-uftc8inx 6895 11 transfusion transfusion NN cord-010092-uftc8inx 6895 12 service service NN cord-010092-uftc8inx 6895 13 . . . cord-010092-uftc8inx 6896 1 For for IN cord-010092-uftc8inx 6896 2 that that DT cord-010092-uftc8inx 6896 3 reason reason NN cord-010092-uftc8inx 6896 4 , , , cord-010092-uftc8inx 6896 5 maintaining maintain VBG cord-010092-uftc8inx 6896 6 a a DT cord-010092-uftc8inx 6896 7 high high JJ cord-010092-uftc8inx 6896 8 quality quality NN cord-010092-uftc8inx 6896 9 in in IN cord-010092-uftc8inx 6896 10 blood blood NN cord-010092-uftc8inx 6896 11 transfusion transfusion NN cord-010092-uftc8inx 6896 12 service service NN cord-010092-uftc8inx 6896 13 is be VBZ cord-010092-uftc8inx 6896 14 required require VBN cord-010092-uftc8inx 6896 15 . . . cord-010092-uftc8inx 6897 1 Pathogen pathogen NN cord-010092-uftc8inx 6897 2 in in IN cord-010092-uftc8inx 6897 3 activated activate VBN cord-010092-uftc8inx 6897 4 plasma plasma NN cord-010092-uftc8inx 6897 5 is be VBZ cord-010092-uftc8inx 6897 6 one one CD cord-010092-uftc8inx 6897 7 of of IN cord-010092-uftc8inx 6897 8 the the DT cord-010092-uftc8inx 6897 9 main main JJ cord-010092-uftc8inx 6897 10 products product NNS cord-010092-uftc8inx 6897 11 that that WDT cord-010092-uftc8inx 6897 12 are be VBP cord-010092-uftc8inx 6897 13 provided provide VBN cord-010092-uftc8inx 6897 14 by by IN cord-010092-uftc8inx 6897 15 the the DT cord-010092-uftc8inx 6897 16 blood blood NN cord-010092-uftc8inx 6897 17 transfusion transfusion NN cord-010092-uftc8inx 6897 18 service service NN cord-010092-uftc8inx 6897 19 . . . cord-010092-uftc8inx 6898 1 The the DT cord-010092-uftc8inx 6898 2 process process NN cord-010092-uftc8inx 6898 3 of of IN cord-010092-uftc8inx 6898 4 producing produce VBG cord-010092-uftc8inx 6898 5 pathogen pathogen NN cord-010092-uftc8inx 6898 6 inactivated inactivate VBN cord-010092-uftc8inx 6898 7 plasma plasma NN cord-010092-uftc8inx 6898 8 involves involve VBZ cord-010092-uftc8inx 6898 9 blood blood NN cord-010092-uftc8inx 6898 10 group group NN cord-010092-uftc8inx 6898 11 matching matching NN cord-010092-uftc8inx 6898 12 step step NN cord-010092-uftc8inx 6898 13 . . . cord-010092-uftc8inx 6899 1 The the DT cord-010092-uftc8inx 6899 2 quality quality NN cord-010092-uftc8inx 6899 3 of of IN cord-010092-uftc8inx 6899 4 this this DT cord-010092-uftc8inx 6899 5 blood blood NN cord-010092-uftc8inx 6899 6 group group NN cord-010092-uftc8inx 6899 7 matching matching NN cord-010092-uftc8inx 6899 8 is be VBZ cord-010092-uftc8inx 6899 9 extremely extremely RB cord-010092-uftc8inx 6899 10 significant significant JJ cord-010092-uftc8inx 6899 11 for for IN cord-010092-uftc8inx 6899 12 the the DT cord-010092-uftc8inx 6899 13 delivery delivery NN cord-010092-uftc8inx 6899 14 of of IN cord-010092-uftc8inx 6899 15 plasma plasma NN cord-010092-uftc8inx 6899 16 that that WDT cord-010092-uftc8inx 6899 17 satisfies satisfy VBZ cord-010092-uftc8inx 6899 18 the the DT cord-010092-uftc8inx 6899 19 recipient recipient NN cord-010092-uftc8inx 6899 20 need need NN cord-010092-uftc8inx 6899 21 . . . cord-010092-uftc8inx 6900 1 Aims aim VBZ cord-010092-uftc8inx 6900 2 : : : cord-010092-uftc8inx 6901 1 The the DT cord-010092-uftc8inx 6901 2 aim aim NN cord-010092-uftc8inx 6901 3 of of IN cord-010092-uftc8inx 6901 4 this this DT cord-010092-uftc8inx 6901 5 study study NN cord-010092-uftc8inx 6901 6 is be VBZ cord-010092-uftc8inx 6901 7 to to TO cord-010092-uftc8inx 6901 8 assess assess VB cord-010092-uftc8inx 6901 9 the the DT cord-010092-uftc8inx 6901 10 quality quality NN cord-010092-uftc8inx 6901 11 of of IN cord-010092-uftc8inx 6901 12 blood blood NN cord-010092-uftc8inx 6901 13 group group NN cord-010092-uftc8inx 6901 14 matching matching NN cord-010092-uftc8inx 6901 15 of of IN cord-010092-uftc8inx 6901 16 pooled pool VBN cord-010092-uftc8inx 6901 17 plasma plasma NN cord-010092-uftc8inx 6901 18 units unit NNS cord-010092-uftc8inx 6901 19 using use VBG cord-010092-uftc8inx 6901 20 Six six CD cord-010092-uftc8inx 6901 21 Sigma Sigma NNP cord-010092-uftc8inx 6901 22 metrics metric NNS cord-010092-uftc8inx 6901 23 , , , cord-010092-uftc8inx 6901 24 and and CC cord-010092-uftc8inx 6901 25 to to TO cord-010092-uftc8inx 6901 26 clarify clarify VB cord-010092-uftc8inx 6901 27 the the DT cord-010092-uftc8inx 6901 28 potential potential JJ cord-010092-uftc8inx 6901 29 implementation implementation NN cord-010092-uftc8inx 6901 30 of of IN cord-010092-uftc8inx 6901 31 six six CD cord-010092-uftc8inx 6901 32 sigma sigma NN cord-010092-uftc8inx 6901 33 metrics metric NNS cord-010092-uftc8inx 6901 34 as as IN cord-010092-uftc8inx 6901 35 a a DT cord-010092-uftc8inx 6901 36 quality quality NN cord-010092-uftc8inx 6901 37 management management NN cord-010092-uftc8inx 6901 38 tool tool NN cord-010092-uftc8inx 6901 39 . . . cord-010092-uftc8inx 6902 1 Methods method NNS cord-010092-uftc8inx 6902 2 : : : cord-010092-uftc8inx 6903 1 This this DT cord-010092-uftc8inx 6903 2 retrospective retrospective JJ cord-010092-uftc8inx 6903 3 study study NN cord-010092-uftc8inx 6903 4 was be VBD cord-010092-uftc8inx 6903 5 conducted conduct VBN cord-010092-uftc8inx 6903 6 in in IN cord-010092-uftc8inx 6903 7 the the DT cord-010092-uftc8inx 6903 8 component component NN cord-010092-uftc8inx 6903 9 preparation preparation NN cord-010092-uftc8inx 6903 10 lab lab NN cord-010092-uftc8inx 6903 11 of of IN cord-010092-uftc8inx 6903 12 Kuwait Kuwait NNP cord-010092-uftc8inx 6903 13 Central Central NNP cord-010092-uftc8inx 6903 14 Blood Blood NNP cord-010092-uftc8inx 6903 15 Bank Bank NNP cord-010092-uftc8inx 6903 16 . . . cord-010092-uftc8inx 6904 1 The the DT cord-010092-uftc8inx 6904 2 twelve twelve CD cord-010092-uftc8inx 6904 3 months month NNS cord-010092-uftc8inx 6904 4 ( ( -LRB- cord-010092-uftc8inx 6904 5 January January NNP cord-010092-uftc8inx 6904 6 2018 2018 CD cord-010092-uftc8inx 6904 7 -December -December NNP cord-010092-uftc8inx 6904 8 2018 2018 CD cord-010092-uftc8inx 6904 9 ) ) -RRB- cord-010092-uftc8inx 6904 10 data datum NNS cord-010092-uftc8inx 6904 11 of of IN cord-010092-uftc8inx 6904 12 pooled pool VBN cord-010092-uftc8inx 6904 13 fresh fresh JJ cord-010092-uftc8inx 6904 14 frozen frozen JJ cord-010092-uftc8inx 6904 15 plasma plasma NN cord-010092-uftc8inx 6904 16 units unit NNS cord-010092-uftc8inx 6904 17 were be VBD cord-010092-uftc8inx 6904 18 recruited recruit VBN cord-010092-uftc8inx 6904 19 and and CC cord-010092-uftc8inx 6904 20 examined examine VBN cord-010092-uftc8inx 6904 21 . . . cord-010092-uftc8inx 6905 1 The the DT cord-010092-uftc8inx 6905 2 data datum NNS cord-010092-uftc8inx 6905 3 was be VBD cord-010092-uftc8inx 6905 4 separated separate VBN cord-010092-uftc8inx 6905 5 to to IN cord-010092-uftc8inx 6905 6 data datum NNS cord-010092-uftc8inx 6905 7 without without IN cord-010092-uftc8inx 6905 8 double double JJ cord-010092-uftc8inx 6905 9 check check NN cord-010092-uftc8inx 6905 10 ( ( -LRB- cord-010092-uftc8inx 6905 11 6 6 CD cord-010092-uftc8inx 6905 12 months month NNS cord-010092-uftc8inx 6905 13 ) ) -RRB- cord-010092-uftc8inx 6905 14 and and CC cord-010092-uftc8inx 6905 15 data datum NNS cord-010092-uftc8inx 6905 16 with with IN cord-010092-uftc8inx 6905 17 double double JJ cord-010092-uftc8inx 6905 18 check check NN cord-010092-uftc8inx 6905 19 ( ( -LRB- cord-010092-uftc8inx 6905 20 6 6 CD cord-010092-uftc8inx 6905 21 months month NNS cord-010092-uftc8inx 6905 22 ) ) -RRB- cord-010092-uftc8inx 6905 23 . . . cord-010092-uftc8inx 6906 1 Data data NN cord-010092-uftc8inx 6906 2 statistics statistic NNS cord-010092-uftc8inx 6906 3 and and CC cord-010092-uftc8inx 6906 4 analysis analysis NN cord-010092-uftc8inx 6906 5 were be VBD cord-010092-uftc8inx 6906 6 conducted conduct VBN cord-010092-uftc8inx 6906 7 by by IN cord-010092-uftc8inx 6906 8 the the DT cord-010092-uftc8inx 6906 9 use use NN cord-010092-uftc8inx 6906 10 of of IN cord-010092-uftc8inx 6906 11 six six CD cord-010092-uftc8inx 6906 12 sigma sigma NN cord-010092-uftc8inx 6906 13 metrics metric NNS cord-010092-uftc8inx 6906 14 . . . cord-010092-uftc8inx 6907 1 Results result NNS cord-010092-uftc8inx 6907 2 : : : cord-010092-uftc8inx 6908 1 In in IN cord-010092-uftc8inx 6908 2 a a DT cord-010092-uftc8inx 6908 3 sample sample NN cord-010092-uftc8inx 6908 4 size size NN cord-010092-uftc8inx 6908 5 of of IN cord-010092-uftc8inx 6908 6 6818 6818 CD cord-010092-uftc8inx 6908 7 from from IN cord-010092-uftc8inx 6908 8 the the DT cord-010092-uftc8inx 6908 9 first first JJ cord-010092-uftc8inx 6908 10 six six CD cord-010092-uftc8inx 6908 11 months month NNS cord-010092-uftc8inx 6908 12 a a DT cord-010092-uftc8inx 6908 13 38 38 CD cord-010092-uftc8inx 6908 14 mismatch mismatch NN cord-010092-uftc8inx 6908 15 was be VBD cord-010092-uftc8inx 6908 16 found find VBN cord-010092-uftc8inx 6908 17 which which WDT cord-010092-uftc8inx 6908 18 equals equal VBZ cord-010092-uftc8inx 6908 19 5573 5573 CD cord-010092-uftc8inx 6908 20 DPMO DPMO NNP cord-010092-uftc8inx 6908 21 and and CC cord-010092-uftc8inx 6908 22 4.1 4.1 CD cord-010092-uftc8inx 6908 23 Sigma Sigma NNP cord-010092-uftc8inx 6908 24 metric metric NN cord-010092-uftc8inx 6908 25 . . . cord-010092-uftc8inx 6909 1 And and CC cord-010092-uftc8inx 6909 2 in in IN cord-010092-uftc8inx 6909 3 a a DT cord-010092-uftc8inx 6909 4 sample sample NN cord-010092-uftc8inx 6909 5 size size NN cord-010092-uftc8inx 6909 6 of of IN cord-010092-uftc8inx 6909 7 5854 5854 CD cord-010092-uftc8inx 6909 8 from from IN cord-010092-uftc8inx 6909 9 the the DT cord-010092-uftc8inx 6909 10 second second JJ cord-010092-uftc8inx 6909 11 six six CD cord-010092-uftc8inx 6909 12 months month NNS cord-010092-uftc8inx 6909 13 a a DT cord-010092-uftc8inx 6909 14 25 25 CD cord-010092-uftc8inx 6909 15 mismatch mismatch NN cord-010092-uftc8inx 6909 16 was be VBD cord-010092-uftc8inx 6909 17 found find VBN cord-010092-uftc8inx 6909 18 which which WDT cord-010092-uftc8inx 6909 19 equals equal VBZ cord-010092-uftc8inx 6909 20 4277 4277 CD cord-010092-uftc8inx 6909 21 DPMO DPMO NNS cord-010092-uftc8inx 6909 22 and and CC cord-010092-uftc8inx 6909 23 4.2 4.2 CD cord-010092-uftc8inx 6909 24 Sigma Sigma NNP cord-010092-uftc8inx 6909 25 metric metric NN cord-010092-uftc8inx 6909 26 . . . cord-010092-uftc8inx 6910 1 Out out IN cord-010092-uftc8inx 6910 2 of of IN cord-010092-uftc8inx 6910 3 the the DT cord-010092-uftc8inx 6910 4 whole whole JJ cord-010092-uftc8inx 6910 5 12672 12672 CD cord-010092-uftc8inx 6910 6 pooled pool VBN cord-010092-uftc8inx 6910 7 units unit NNS cord-010092-uftc8inx 6910 8 63 63 CD cord-010092-uftc8inx 6910 9 were be VBD cord-010092-uftc8inx 6910 10 found find VBN cord-010092-uftc8inx 6910 11 to to TO cord-010092-uftc8inx 6910 12 be be VB cord-010092-uftc8inx 6910 13 mismatched mismatch VBN cord-010092-uftc8inx 6910 14 . . . cord-010092-uftc8inx 6911 1 Some some DT cord-010092-uftc8inx 6911 2 of of IN cord-010092-uftc8inx 6911 3 which which WDT cord-010092-uftc8inx 6911 4 were be VBD cord-010092-uftc8inx 6911 5 found find VBN cord-010092-uftc8inx 6911 6 to to TO cord-010092-uftc8inx 6911 7 be be VB cord-010092-uftc8inx 6911 8 discarded discard VBN cord-010092-uftc8inx 6911 9 as as IN cord-010092-uftc8inx 6911 10 ABO ABO NNP cord-010092-uftc8inx 6911 11 discrepancy discrepancy NN cord-010092-uftc8inx 6911 12 , , , cord-010092-uftc8inx 6911 13 broken break VBN cord-010092-uftc8inx 6911 14 , , , cord-010092-uftc8inx 6911 15 or or CC cord-010092-uftc8inx 6911 16 expired expire VBN cord-010092-uftc8inx 6911 17 . . . cord-010092-uftc8inx 6912 1 Other other JJ cord-010092-uftc8inx 6912 2 was be VBD cord-010092-uftc8inx 6912 3 still still RB cord-010092-uftc8inx 6912 4 available available JJ cord-010092-uftc8inx 6912 5 in in IN cord-010092-uftc8inx 6912 6 the the DT cord-010092-uftc8inx 6912 7 system system NN cord-010092-uftc8inx 6912 8 , , , cord-010092-uftc8inx 6912 9 while while IN cord-010092-uftc8inx 6912 10 the the DT cord-010092-uftc8inx 6912 11 rest rest NN cord-010092-uftc8inx 6912 12 of of IN cord-010092-uftc8inx 6912 13 the the DT cord-010092-uftc8inx 6912 14 mismatched mismatched JJ cord-010092-uftc8inx 6912 15 units unit NNS cord-010092-uftc8inx 6912 16 were be VBD cord-010092-uftc8inx 6912 17 issued issue VBN cord-010092-uftc8inx 6912 18 . . . cord-010092-uftc8inx 6913 1 Summary Summary NNP cord-010092-uftc8inx 6913 2 / / SYM cord-010092-uftc8inx 6913 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 6913 4 : : : cord-010092-uftc8inx 6914 1 Using use VBG cord-010092-uftc8inx 6914 2 the the DT cord-010092-uftc8inx 6914 3 Six six CD cord-010092-uftc8inx 6914 4 Sigma Sigma NNP cord-010092-uftc8inx 6914 5 principle principle NN cord-010092-uftc8inx 6914 6 the the DT cord-010092-uftc8inx 6914 7 study study NN cord-010092-uftc8inx 6914 8 presents present VBZ cord-010092-uftc8inx 6914 9 a a DT cord-010092-uftc8inx 6914 10 successful successful JJ cord-010092-uftc8inx 6914 11 assessment assessment NN cord-010092-uftc8inx 6914 12 of of IN cord-010092-uftc8inx 6914 13 blood blood NN cord-010092-uftc8inx 6914 14 group group NN cord-010092-uftc8inx 6914 15 matching match VBG cord-010092-uftc8inx 6914 16 quality quality NN cord-010092-uftc8inx 6914 17 . . . cord-010092-uftc8inx 6915 1 As as IN cord-010092-uftc8inx 6915 2 a a DT cord-010092-uftc8inx 6915 3 4.1 4.1 CD cord-010092-uftc8inx 6915 4 sigma sigma NN cord-010092-uftc8inx 6915 5 metrics metric NNS cord-010092-uftc8inx 6915 6 obtained obtain VBN cord-010092-uftc8inx 6915 7 from from IN cord-010092-uftc8inx 6915 8 the the DT cord-010092-uftc8inx 6915 9 first first JJ cord-010092-uftc8inx 6915 10 6 6 CD cord-010092-uftc8inx 6915 11 months month NNS cord-010092-uftc8inx 6915 12 , , , cord-010092-uftc8inx 6915 13 were be VBD cord-010092-uftc8inx 6915 14 shifted shift VBN cord-010092-uftc8inx 6915 15 to to IN cord-010092-uftc8inx 6915 16 a a DT cord-010092-uftc8inx 6915 17 sigma sigma NN cord-010092-uftc8inx 6915 18 metrics metric NNS cord-010092-uftc8inx 6915 19 of of IN cord-010092-uftc8inx 6915 20 4.2 4.2 CD cord-010092-uftc8inx 6915 21 in in IN cord-010092-uftc8inx 6915 22 the the DT cord-010092-uftc8inx 6915 23 second second JJ cord-010092-uftc8inx 6915 24 6 6 CD cord-010092-uftc8inx 6915 25 months month NNS cord-010092-uftc8inx 6915 26 , , , cord-010092-uftc8inx 6915 27 after after IN cord-010092-uftc8inx 6915 28 the the DT cord-010092-uftc8inx 6915 29 addition addition NN cord-010092-uftc8inx 6915 30 of of IN cord-010092-uftc8inx 6915 31 a a DT cord-010092-uftc8inx 6915 32 double double JJ cord-010092-uftc8inx 6915 33 - - HYPH cord-010092-uftc8inx 6915 34 checking checking NN cord-010092-uftc8inx 6915 35 step step NN cord-010092-uftc8inx 6915 36 to to IN cord-010092-uftc8inx 6915 37 the the DT cord-010092-uftc8inx 6915 38 blood blood NN cord-010092-uftc8inx 6915 39 group group NN cord-010092-uftc8inx 6915 40 matching matching NN cord-010092-uftc8inx 6915 41 of of IN cord-010092-uftc8inx 6915 42 pooled pool VBN cord-010092-uftc8inx 6915 43 plasma plasma NN cord-010092-uftc8inx 6915 44 process process NN cord-010092-uftc8inx 6915 45 . . . cord-010092-uftc8inx 6916 1 The the DT cord-010092-uftc8inx 6916 2 implementation implementation NN cord-010092-uftc8inx 6916 3 of of IN cord-010092-uftc8inx 6916 4 these these DT cord-010092-uftc8inx 6916 5 metrics metric NNS cord-010092-uftc8inx 6916 6 in in IN cord-010092-uftc8inx 6916 7 our -PRON- PRP$ cord-010092-uftc8inx 6916 8 laboratory laboratory NN cord-010092-uftc8inx 6916 9 quality quality NN cord-010092-uftc8inx 6916 10 management management NN cord-010092-uftc8inx 6916 11 has have VBZ cord-010092-uftc8inx 6916 12 been be VBN cord-010092-uftc8inx 6916 13 shown show VBN cord-010092-uftc8inx 6916 14 to to TO cord-010092-uftc8inx 6916 15 be be VB cord-010092-uftc8inx 6916 16 very very RB cord-010092-uftc8inx 6916 17 beneficial beneficial JJ cord-010092-uftc8inx 6916 18 . . . cord-010092-uftc8inx 6917 1 In in IN cord-010092-uftc8inx 6917 2 which which WDT cord-010092-uftc8inx 6917 3 Six six CD cord-010092-uftc8inx 6917 4 - - HYPH cord-010092-uftc8inx 6917 5 sigma sigma NN cord-010092-uftc8inx 6917 6 metrics metric NNS cord-010092-uftc8inx 6917 7 were be VBD cord-010092-uftc8inx 6917 8 able able JJ cord-010092-uftc8inx 6917 9 to to TO cord-010092-uftc8inx 6917 10 clarify clarify VB cord-010092-uftc8inx 6917 11 the the DT cord-010092-uftc8inx 6917 12 reduction reduction NN cord-010092-uftc8inx 6917 13 in in IN cord-010092-uftc8inx 6917 14 blood blood NN cord-010092-uftc8inx 6917 15 group group NN cord-010092-uftc8inx 6917 16 matching matching NN cord-010092-uftc8inx 6917 17 errors error NNS cord-010092-uftc8inx 6917 18 . . . cord-010092-uftc8inx 6918 1 Although although IN cord-010092-uftc8inx 6918 2 Six six CD cord-010092-uftc8inx 6918 3 - - HYPH cord-010092-uftc8inx 6918 4 sigma sigma NN cord-010092-uftc8inx 6918 5 benefits benefit NNS cord-010092-uftc8inx 6918 6 in in IN cord-010092-uftc8inx 6918 7 major major JJ cord-010092-uftc8inx 6918 8 quality quality NN cord-010092-uftc8inx 6918 9 improvements improvement NNS cord-010092-uftc8inx 6918 10 and and CC cord-010092-uftc8inx 6918 11 helps help VBZ cord-010092-uftc8inx 6918 12 to to TO cord-010092-uftc8inx 6918 13 reach reach VB cord-010092-uftc8inx 6918 14 an an DT cord-010092-uftc8inx 6918 15 error error NN cord-010092-uftc8inx 6918 16 free free JJ cord-010092-uftc8inx 6918 17 laboratory laboratory NN cord-010092-uftc8inx 6918 18 services service NNS cord-010092-uftc8inx 6918 19 , , , cord-010092-uftc8inx 6918 20 yet yet RB cord-010092-uftc8inx 6919 1 it -PRON- PRP cord-010092-uftc8inx 6919 2 presents present VBZ cord-010092-uftc8inx 6919 3 a a DT cord-010092-uftc8inx 6919 4 new new JJ cord-010092-uftc8inx 6919 5 challenge challenge NN cord-010092-uftc8inx 6919 6 to to IN cord-010092-uftc8inx 6919 7 laboratory laboratory NN cord-010092-uftc8inx 6919 8 practitioners practitioner NNS cord-010092-uftc8inx 6919 9 . . . cord-010092-uftc8inx 6920 1 Currently currently RB cord-010092-uftc8inx 6920 2 , , , cord-010092-uftc8inx 6920 3 the the DT cord-010092-uftc8inx 6920 4 hemophilia hemophilia NN cord-010092-uftc8inx 6921 1 A a DT cord-010092-uftc8inx 6921 2 patients patient NNS cord-010092-uftc8inx 6921 3 treated treat VBN cord-010092-uftc8inx 6921 4 with with IN cord-010092-uftc8inx 6921 5 Factor Factor NNP cord-010092-uftc8inx 6921 6 VIII VIII NNP cord-010092-uftc8inx 6921 7 concentrated concentrate VBD cord-010092-uftc8inx 6921 8 as as IN cord-010092-uftc8inx 6921 9 the the DT cord-010092-uftc8inx 6921 10 first first JJ cord-010092-uftc8inx 6921 11 line line NN cord-010092-uftc8inx 6921 12 of of IN cord-010092-uftc8inx 6921 13 therapy therapy NN cord-010092-uftc8inx 6922 1 but but CC cord-010092-uftc8inx 6922 2 it -PRON- PRP cord-010092-uftc8inx 6922 3 is be VBZ cord-010092-uftc8inx 6922 4 more more RBR cord-010092-uftc8inx 6922 5 expensive expensive JJ cord-010092-uftc8inx 6922 6 and and CC cord-010092-uftc8inx 6922 7 the the DT cord-010092-uftc8inx 6922 8 supply supply NN cord-010092-uftc8inx 6922 9 is be VBZ cord-010092-uftc8inx 6922 10 not not RB cord-010092-uftc8inx 6922 11 sufficient sufficient JJ cord-010092-uftc8inx 6922 12 so so RB cord-010092-uftc8inx 6922 13 for for IN cord-010092-uftc8inx 6922 14 now now RB cord-010092-uftc8inx 6923 1 they -PRON- PRP cord-010092-uftc8inx 6923 2 have have VBP cord-010092-uftc8inx 6923 3 not not RB cord-010092-uftc8inx 6923 4 used use VBN cord-010092-uftc8inx 6923 5 Factor Factor NNP cord-010092-uftc8inx 6923 6 VIII VIII NNP cord-010092-uftc8inx 6923 7 concentrate concentrate NN cord-010092-uftc8inx 6923 8 as as IN cord-010092-uftc8inx 6923 9 prophylaxis prophylaxis NN cord-010092-uftc8inx 6923 10 therapy therapy NN cord-010092-uftc8inx 6923 11 . . . cord-010092-uftc8inx 6924 1 For for IN cord-010092-uftc8inx 6924 2 some some DT cord-010092-uftc8inx 6924 3 cases case NNS cord-010092-uftc8inx 6924 4 , , , cord-010092-uftc8inx 6924 5 Hemophilia Hemophilia NNP cord-010092-uftc8inx 6924 6 patients patient NNS cord-010092-uftc8inx 6924 7 in in IN cord-010092-uftc8inx 6924 8 Indonesia Indonesia NNP cord-010092-uftc8inx 6924 9 depend depend VBP cord-010092-uftc8inx 6924 10 on on IN cord-010092-uftc8inx 6924 11 subsidy subsidy NN cord-010092-uftc8inx 6924 12 from from IN cord-010092-uftc8inx 6924 13 the the DT cord-010092-uftc8inx 6924 14 World World NNP cord-010092-uftc8inx 6924 15 Federation Federation NNP cord-010092-uftc8inx 6924 16 of of IN cord-010092-uftc8inx 6924 17 Hemophilia Hemophilia NNP cord-010092-uftc8inx 6924 18 . . . cord-010092-uftc8inx 6925 1 The the DT cord-010092-uftc8inx 6925 2 first first JJ cord-010092-uftc8inx 6925 3 handicapped handicapped JJ cord-010092-uftc8inx 6925 4 concentrated concentrated JJ cord-010092-uftc8inx 6925 5 case case NN cord-010092-uftc8inx 6925 6 is be VBZ cord-010092-uftc8inx 6925 7 just just RB cord-010092-uftc8inx 6925 8 for for IN cord-010092-uftc8inx 6925 9 therapy therapy NN cord-010092-uftc8inx 6925 10 not not RB cord-010092-uftc8inx 6925 11 for for IN cord-010092-uftc8inx 6925 12 prophylaxis prophylaxis NN cord-010092-uftc8inx 6925 13 . . . cord-010092-uftc8inx 6926 1 Big big JJ cord-010092-uftc8inx 6926 2 Blood blood NN cord-010092-uftc8inx 6926 3 Centers Centers NNPS cord-010092-uftc8inx 6926 4 in in IN cord-010092-uftc8inx 6926 5 Indonesia Indonesia NNP cord-010092-uftc8inx 6926 6 produce produce VBP cord-010092-uftc8inx 6926 7 routinely routinely RB cord-010092-uftc8inx 6926 8 Fresh Fresh NNP cord-010092-uftc8inx 6926 9 Frozen Frozen NNP cord-010092-uftc8inx 6926 10 Plasma Plasma NNP cord-010092-uftc8inx 6926 11 ( ( -LRB- cord-010092-uftc8inx 6926 12 FFP FFP NNP cord-010092-uftc8inx 6926 13 ) ) -RRB- cord-010092-uftc8inx 6926 14 and and CC cord-010092-uftc8inx 6926 15 cryoprecipitate cryoprecipitate JJ cord-010092-uftc8inx 6926 16 - - HYPH cord-010092-uftc8inx 6926 17 Anti Anti NNP cord-010092-uftc8inx 6926 18 Hemophilic Hemophilic NNP cord-010092-uftc8inx 6926 19 Factor factor NN cord-010092-uftc8inx 6926 20 ( ( -LRB- cord-010092-uftc8inx 6926 21 AHF AHF NNP cord-010092-uftc8inx 6926 22 ) ) -RRB- cord-010092-uftc8inx 6926 23 as as IN cord-010092-uftc8inx 6926 24 replacement replacement NN cord-010092-uftc8inx 6926 25 therapy therapy NN cord-010092-uftc8inx 6926 26 for for IN cord-010092-uftc8inx 6926 27 Hemophilia Hemophilia NNP cord-010092-uftc8inx 6926 28 A A NNP cord-010092-uftc8inx 6926 29 , , , cord-010092-uftc8inx 6926 30 but but CC cord-010092-uftc8inx 6926 31 its -PRON- PRP$ cord-010092-uftc8inx 6926 32 content content NN cord-010092-uftc8inx 6926 33 and and CC cord-010092-uftc8inx 6926 34 safety safety NN cord-010092-uftc8inx 6926 35 of of IN cord-010092-uftc8inx 6926 36 Factor Factor NNP cord-010092-uftc8inx 6926 37 VIII VIII NNP cord-010092-uftc8inx 6926 38 from from IN cord-010092-uftc8inx 6926 39 150 150 CD cord-010092-uftc8inx 6926 40 mL ml NN cord-010092-uftc8inx 6926 41 FFP ffp NN cord-010092-uftc8inx 6926 42 need need NN cord-010092-uftc8inx 6926 43 to to TO cord-010092-uftc8inx 6926 44 be be VB cord-010092-uftc8inx 6926 45 improved improve VBN cord-010092-uftc8inx 6926 46 . . . cord-010092-uftc8inx 6927 1 Nowadays nowadays RB cord-010092-uftc8inx 6927 2 , , , cord-010092-uftc8inx 6927 3 there there EX cord-010092-uftc8inx 6927 4 is be VBZ cord-010092-uftc8inx 6927 5 an an DT cord-010092-uftc8inx 6927 6 available available JJ cord-010092-uftc8inx 6927 7 kit kit NN cord-010092-uftc8inx 6927 8 for for IN cord-010092-uftc8inx 6927 9 producing produce VBG cord-010092-uftc8inx 6927 10 minipool minipool NNP cord-010092-uftc8inx 6927 11 cryoprecipitate cryoprecipitate NNP cord-010092-uftc8inx 6927 12 ( ( -LRB- cord-010092-uftc8inx 6927 13 MC MC NNP cord-010092-uftc8inx 6927 14 ) ) -RRB- cord-010092-uftc8inx 6927 15 that that WDT cord-010092-uftc8inx 6927 16 has have VBZ cord-010092-uftc8inx 6927 17 better well JJR cord-010092-uftc8inx 6927 18 safety safety NN cord-010092-uftc8inx 6927 19 and and CC cord-010092-uftc8inx 6927 20 quality quality NN cord-010092-uftc8inx 6928 1 but but CC cord-010092-uftc8inx 6928 2 it -PRON- PRP cord-010092-uftc8inx 6928 3 is be VBZ cord-010092-uftc8inx 6928 4 available available JJ cord-010092-uftc8inx 6928 5 as as IN cord-010092-uftc8inx 6928 6 liquid liquid JJ cord-010092-uftc8inx 6928 7 products product NNS cord-010092-uftc8inx 6928 8 , , , cord-010092-uftc8inx 6928 9 stored store VBN cord-010092-uftc8inx 6928 10 in in IN cord-010092-uftc8inx 6928 11 very very RB cord-010092-uftc8inx 6928 12 strict strict JJ cord-010092-uftc8inx 6928 13 and and CC cord-010092-uftc8inx 6928 14 specific specific JJ cord-010092-uftc8inx 6928 15 temperature temperature NN cord-010092-uftc8inx 6928 16 ( ( -LRB- cord-010092-uftc8inx 6928 17 À20 À20 NNP cord-010092-uftc8inx 6928 18 ° ° NN cord-010092-uftc8inx 6928 19 C C NNP cord-010092-uftc8inx 6928 20 ) ) -RRB- cord-010092-uftc8inx 6928 21 . . . cord-010092-uftc8inx 6929 1 Prophylaxis prophylaxis NN cord-010092-uftc8inx 6929 2 therapy therapy NN cord-010092-uftc8inx 6929 3 for for IN cord-010092-uftc8inx 6929 4 Hemophilia Hemophilia NNP cord-010092-uftc8inx 6929 5 patients patient NNS cord-010092-uftc8inx 6929 6 needs need VBZ cord-010092-uftc8inx 6929 7 a a DT cord-010092-uftc8inx 6929 8 stable stable JJ cord-010092-uftc8inx 6929 9 product product NN cord-010092-uftc8inx 6929 10 , , , cord-010092-uftc8inx 6929 11 easy easy JJ cord-010092-uftc8inx 6929 12 to to TO cord-010092-uftc8inx 6929 13 use use VB cord-010092-uftc8inx 6929 14 and and CC cord-010092-uftc8inx 6929 15 convenient convenient JJ cord-010092-uftc8inx 6929 16 treatment treatment NN cord-010092-uftc8inx 6929 17 for for IN cord-010092-uftc8inx 6929 18 patients patient NNS cord-010092-uftc8inx 6929 19 . . . cord-010092-uftc8inx 6930 1 Aims aim VBZ cord-010092-uftc8inx 6930 2 : : : cord-010092-uftc8inx 6930 3 To to TO cord-010092-uftc8inx 6930 4 analyze analyze VB cord-010092-uftc8inx 6930 5 the the DT cord-010092-uftc8inx 6930 6 content content NN cord-010092-uftc8inx 6930 7 and and CC cord-010092-uftc8inx 6930 8 safety safety NN cord-010092-uftc8inx 6930 9 of of IN cord-010092-uftc8inx 6930 10 F F NNP cord-010092-uftc8inx 6930 11 VIII VIII NNP cord-010092-uftc8inx 6930 12 with with IN cord-010092-uftc8inx 6930 13 minipool minipool NNP cord-010092-uftc8inx 6930 14 cryoprecipitate cryoprecipitate NNP cord-010092-uftc8inx 6930 15 ( ( -LRB- cord-010092-uftc8inx 6930 16 MC MC NNP cord-010092-uftc8inx 6930 17 ) ) -RRB- cord-010092-uftc8inx 6930 18 and and CC cord-010092-uftc8inx 6930 19 Lyophilized Lyophilized NNP cord-010092-uftc8inx 6930 20 MC MC NNP cord-010092-uftc8inx 6930 21 for for IN cord-010092-uftc8inx 6930 22 home home NN cord-010092-uftc8inx 6930 23 therapy therapy NN cord-010092-uftc8inx 6930 24 . . . cord-010092-uftc8inx 6931 1 Methods method NNS cord-010092-uftc8inx 6931 2 : : : cord-010092-uftc8inx 6931 3 We -PRON- PRP cord-010092-uftc8inx 6931 4 produced produce VBD cord-010092-uftc8inx 6931 5 7 7 CD cord-010092-uftc8inx 6931 6 MC MC NNP cord-010092-uftc8inx 6931 7 ; ; : cord-010092-uftc8inx 6932 1 1 1 CD cord-010092-uftc8inx 6932 2 MC MC NNP cord-010092-uftc8inx 6932 3 as as IN cord-010092-uftc8inx 6932 4 the the DT cord-010092-uftc8inx 6932 5 control control NN cord-010092-uftc8inx 6932 6 , , , cord-010092-uftc8inx 6932 7 3 3 CD cord-010092-uftc8inx 6932 8 MC MC NNP cord-010092-uftc8inx 6932 9 were be VBD cord-010092-uftc8inx 6932 10 lyophilized lyophilize VBN cord-010092-uftc8inx 6932 11 with with IN cord-010092-uftc8inx 6932 12 excipient excipient NN cord-010092-uftc8inx 6932 13 and and CC cord-010092-uftc8inx 6932 14 3 3 CD cord-010092-uftc8inx 6932 15 MC MC NNP cord-010092-uftc8inx 6932 16 without without IN cord-010092-uftc8inx 6932 17 excipient excipient NN cord-010092-uftc8inx 6932 18 . . . cord-010092-uftc8inx 6933 1 We -PRON- PRP cord-010092-uftc8inx 6933 2 analyzed analyze VBD cord-010092-uftc8inx 6933 3 the the DT cord-010092-uftc8inx 6933 4 number number NN cord-010092-uftc8inx 6933 5 of of IN cord-010092-uftc8inx 6933 6 Factor Factor NNP cord-010092-uftc8inx 6933 7 VIII VIII NNP cord-010092-uftc8inx 6933 8 , , , cord-010092-uftc8inx 6933 9 the the DT cord-010092-uftc8inx 6933 10 Safety Safety NNP cord-010092-uftc8inx 6933 11 , , , cord-010092-uftc8inx 6933 12 and and CC cord-010092-uftc8inx 6933 13 stability stability NN cord-010092-uftc8inx 6933 14 . . . cord-010092-uftc8inx 6934 1 We -PRON- PRP cord-010092-uftc8inx 6934 2 count count VBP cord-010092-uftc8inx 6934 3 the the DT cord-010092-uftc8inx 6934 4 erythrocyte erythrocyte NN cord-010092-uftc8inx 6934 5 , , , cord-010092-uftc8inx 6934 6 leukocyte leukocyte NN cord-010092-uftc8inx 6934 7 and and CC cord-010092-uftc8inx 6934 8 platelet platelet NN cord-010092-uftc8inx 6934 9 residual residual NN cord-010092-uftc8inx 6934 10 in in IN cord-010092-uftc8inx 6934 11 MC MC NNP cord-010092-uftc8inx 6934 12 using use VBG cord-010092-uftc8inx 6934 13 flow flow NN cord-010092-uftc8inx 6934 14 cytometry cytometry NN cord-010092-uftc8inx 6934 15 . . . cord-010092-uftc8inx 6935 1 We -PRON- PRP cord-010092-uftc8inx 6935 2 also also RB cord-010092-uftc8inx 6935 3 measure measure VBP cord-010092-uftc8inx 6935 4 the the DT cord-010092-uftc8inx 6935 5 pH ph NN cord-010092-uftc8inx 6935 6 , , , cord-010092-uftc8inx 6935 7 Osmolality Osmolality NNP cord-010092-uftc8inx 6935 8 , , , cord-010092-uftc8inx 6935 9 Solubility solubility NN cord-010092-uftc8inx 6935 10 to to TO cord-010092-uftc8inx 6935 11 learn learn VB cord-010092-uftc8inx 6935 12 its -PRON- PRP$ cord-010092-uftc8inx 6935 13 stability stability NN cord-010092-uftc8inx 6935 14 after after IN cord-010092-uftc8inx 6935 15 storage storage NN cord-010092-uftc8inx 6935 16 at at IN cord-010092-uftc8inx 6935 17 30 30 CD cord-010092-uftc8inx 6935 18 days day NNS cord-010092-uftc8inx 6935 19 at at IN cord-010092-uftc8inx 6935 20 room room NN cord-010092-uftc8inx 6935 21 temperature temperature NN cord-010092-uftc8inx 6935 22 ( ( -LRB- cord-010092-uftc8inx 6935 23 30 30 CD cord-010092-uftc8inx 6935 24 - - SYM cord-010092-uftc8inx 6935 25 32 32 CD cord-010092-uftc8inx 6935 26 ° ° NN cord-010092-uftc8inx 6935 27 C c NN cord-010092-uftc8inx 6935 28 ) ) -RRB- cord-010092-uftc8inx 6935 29 and and CC cord-010092-uftc8inx 6935 30 blood blood NN cord-010092-uftc8inx 6935 31 bank bank NN cord-010092-uftc8inx 6935 32 refrigerator refrigerator NN cord-010092-uftc8inx 6935 33 temperature temperature NN cord-010092-uftc8inx 6935 34 ( ( -LRB- cord-010092-uftc8inx 6935 35 2 2 CD cord-010092-uftc8inx 6935 36 - - SYM cord-010092-uftc8inx 6935 37 8 8 CD cord-010092-uftc8inx 6935 38 ° ° NN cord-010092-uftc8inx 6935 39 C c NN cord-010092-uftc8inx 6935 40 ) ) -RRB- cord-010092-uftc8inx 6935 41 at at IN cord-010092-uftc8inx 6935 42 Central Central NNP cord-010092-uftc8inx 6935 43 Blood Blood NNP cord-010092-uftc8inx 6935 44 Transfusion Transfusion NNP cord-010092-uftc8inx 6935 45 Services Services NNPS cord-010092-uftc8inx 6935 46 ( ( -LRB- cord-010092-uftc8inx 6935 47 CBTS CBTS NNP cord-010092-uftc8inx 6935 48 ) ) -RRB- cord-010092-uftc8inx 6935 49 . . . cord-010092-uftc8inx 6936 1 Results result NNS cord-010092-uftc8inx 6936 2 : : : cord-010092-uftc8inx 6937 1 We -PRON- PRP cord-010092-uftc8inx 6937 2 found find VBD cord-010092-uftc8inx 6937 3 the the DT cord-010092-uftc8inx 6937 4 content content NN cord-010092-uftc8inx 6937 5 F F NNP cord-010092-uftc8inx 6937 6 VIII VIII NNP cord-010092-uftc8inx 6937 7 with with IN cord-010092-uftc8inx 6937 8 excipient excipient NN cord-010092-uftc8inx 6937 9 is be VBZ cord-010092-uftc8inx 6937 10 higher high JJR cord-010092-uftc8inx 6938 1 ( ( -LRB- cord-010092-uftc8inx 6938 2 9.8 9.8 CD cord-010092-uftc8inx 6938 3 IU IU NNP cord-010092-uftc8inx 6938 4 / / SYM cord-010092-uftc8inx 6938 5 mL mL NNP cord-010092-uftc8inx 6938 6 ) ) -RRB- cord-010092-uftc8inx 6938 7 than than IN cord-010092-uftc8inx 6938 8 without without IN cord-010092-uftc8inx 6938 9 excipient excipient NN cord-010092-uftc8inx 6938 10 ( ( -LRB- cord-010092-uftc8inx 6938 11 4.5 4.5 CD cord-010092-uftc8inx 6938 12 IU IU NNP cord-010092-uftc8inx 6938 13 / / SYM cord-010092-uftc8inx 6938 14 mL mL NNP cord-010092-uftc8inx 6938 15 ) ) -RRB- cord-010092-uftc8inx 6938 16 and and CC cord-010092-uftc8inx 6938 17 the the DT cord-010092-uftc8inx 6938 18 storage storage NN cord-010092-uftc8inx 6938 19 at at IN cord-010092-uftc8inx 6938 20 blood blood NN cord-010092-uftc8inx 6938 21 bank bank NN cord-010092-uftc8inx 6938 22 refrigerator refrigerator NN cord-010092-uftc8inx 6938 23 ( ( -LRB- cord-010092-uftc8inx 6938 24 2 2 CD cord-010092-uftc8inx 6938 25 - - SYM cord-010092-uftc8inx 6938 26 8 8 CD cord-010092-uftc8inx 6938 27 ° ° NN cord-010092-uftc8inx 6938 28 C c NN cord-010092-uftc8inx 6938 29 ) ) -RRB- cord-010092-uftc8inx 6938 30 is be VBZ cord-010092-uftc8inx 6938 31 better well JJR cord-010092-uftc8inx 6938 32 than than IN cord-010092-uftc8inx 6938 33 at at IN cord-010092-uftc8inx 6938 34 room room NN cord-010092-uftc8inx 6938 35 temperature temperature NN cord-010092-uftc8inx 6938 36 ( ( -LRB- cord-010092-uftc8inx 6938 37 30 30 CD cord-010092-uftc8inx 6938 38 - - SYM cord-010092-uftc8inx 6938 39 32 32 CD cord-010092-uftc8inx 6938 40 ° ° NN cord-010092-uftc8inx 6938 41 C C NNP cord-010092-uftc8inx 6938 42 ) ) -RRB- cord-010092-uftc8inx 6938 43 . . . cord-010092-uftc8inx 6939 1 In in IN cord-010092-uftc8inx 6939 2 both both DT cord-010092-uftc8inx 6939 3 group group NN cord-010092-uftc8inx 6939 4 , , , cord-010092-uftc8inx 6939 5 there there EX cord-010092-uftc8inx 6939 6 were be VBD cord-010092-uftc8inx 6939 7 no no DT cord-010092-uftc8inx 6939 8 residual residual JJ cord-010092-uftc8inx 6939 9 cells cell NNS cord-010092-uftc8inx 6939 10 and and CC cord-010092-uftc8inx 6939 11 bacterial bacterial JJ cord-010092-uftc8inx 6939 12 found find VBN cord-010092-uftc8inx 6939 13 in in IN cord-010092-uftc8inx 6939 14 MC MC NNP cord-010092-uftc8inx 6939 15 . . . cord-010092-uftc8inx 6940 1 No no DT cord-010092-uftc8inx 6940 2 significant significant JJ cord-010092-uftc8inx 6940 3 difference difference NN cord-010092-uftc8inx 6940 4 in in IN cord-010092-uftc8inx 6940 5 The the DT cord-010092-uftc8inx 6940 6 pH ph NN cord-010092-uftc8inx 6940 7 , , , cord-010092-uftc8inx 6940 8 osmolality osmolality NN cord-010092-uftc8inx 6940 9 and and CC cord-010092-uftc8inx 6940 10 solubility solubility NN cord-010092-uftc8inx 6940 11 in in IN cord-010092-uftc8inx 6940 12 both both DT cord-010092-uftc8inx 6940 13 groups group NNS cord-010092-uftc8inx 6940 14 . . . cord-010092-uftc8inx 6941 1 Summary Summary NNP cord-010092-uftc8inx 6941 2 / / SYM cord-010092-uftc8inx 6941 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 6941 4 : : : cord-010092-uftc8inx 6942 1 The the DT cord-010092-uftc8inx 6942 2 Lyophilized Lyophilized NNP cord-010092-uftc8inx 6942 3 MC MC NNP cord-010092-uftc8inx 6942 4 with with IN cord-010092-uftc8inx 6942 5 excipient excipient NN cord-010092-uftc8inx 6942 6 stored store VBN cord-010092-uftc8inx 6942 7 at at IN cord-010092-uftc8inx 6942 8 blood blood NN cord-010092-uftc8inx 6942 9 bank bank NN cord-010092-uftc8inx 6942 10 temperature temperature NN cord-010092-uftc8inx 6942 11 ( ( -LRB- cord-010092-uftc8inx 6942 12 2 2 CD cord-010092-uftc8inx 6942 13 - - SYM cord-010092-uftc8inx 6942 14 8 8 CD cord-010092-uftc8inx 6942 15 ° ° NN cord-010092-uftc8inx 6942 16 C c NN cord-010092-uftc8inx 6942 17 ) ) -RRB- cord-010092-uftc8inx 6942 18 is be VBZ cord-010092-uftc8inx 6942 19 better well JJR cord-010092-uftc8inx 6942 20 than than IN cord-010092-uftc8inx 6942 21 room room NN cord-010092-uftc8inx 6942 22 temperature temperature NN cord-010092-uftc8inx 6942 23 . . . cord-010092-uftc8inx 6943 1 This this DT cord-010092-uftc8inx 6943 2 experiment experiment NN cord-010092-uftc8inx 6943 3 will will MD cord-010092-uftc8inx 6943 4 be be VB cord-010092-uftc8inx 6943 5 continued continue VBN cord-010092-uftc8inx 6943 6 to to TO cord-010092-uftc8inx 6943 7 know know VB cord-010092-uftc8inx 6943 8 its -PRON- PRP$ cord-010092-uftc8inx 6943 9 stability stability NN cord-010092-uftc8inx 6943 10 in in IN cord-010092-uftc8inx 6943 11 extended extended JJ cord-010092-uftc8inx 6943 12 storage storage NN cord-010092-uftc8inx 6943 13 time time NN cord-010092-uftc8inx 6943 14 . . . cord-010092-uftc8inx 6944 1 Background background NN cord-010092-uftc8inx 6944 2 : : : cord-010092-uftc8inx 6945 1 Peptic peptic JJ cord-010092-uftc8inx 6945 2 ulcer ulcer NN cord-010092-uftc8inx 6945 3 disease disease NN cord-010092-uftc8inx 6945 4 ( ( -LRB- cord-010092-uftc8inx 6945 5 PUD PUD NNP cord-010092-uftc8inx 6945 6 ) ) -RRB- cord-010092-uftc8inx 6945 7 is be VBZ cord-010092-uftc8inx 6945 8 a a DT cord-010092-uftc8inx 6945 9 multifactorial multifactorial JJ cord-010092-uftc8inx 6945 10 and and CC cord-010092-uftc8inx 6945 11 complex complex JJ cord-010092-uftc8inx 6945 12 disease disease NN cord-010092-uftc8inx 6945 13 , , , cord-010092-uftc8inx 6945 14 and and CC cord-010092-uftc8inx 6945 15 it -PRON- PRP cord-010092-uftc8inx 6945 16 affects affect VBZ cord-010092-uftc8inx 6945 17 a a DT cord-010092-uftc8inx 6945 18 wide wide JJ cord-010092-uftc8inx 6945 19 range range NN cord-010092-uftc8inx 6945 20 of of IN cord-010092-uftc8inx 6945 21 people people NNS cord-010092-uftc8inx 6945 22 in in IN cord-010092-uftc8inx 6945 23 the the DT cord-010092-uftc8inx 6945 24 world world NN cord-010092-uftc8inx 6945 25 . . . cord-010092-uftc8inx 6946 1 However however RB cord-010092-uftc8inx 6946 2 , , , cord-010092-uftc8inx 6946 3 a a DT cord-010092-uftc8inx 6946 4 perfect perfect JJ cord-010092-uftc8inx 6946 5 therapy therapy NN cord-010092-uftc8inx 6946 6 for for IN cord-010092-uftc8inx 6946 7 PUD PUD NNP cord-010092-uftc8inx 6946 8 has have VBZ cord-010092-uftc8inx 6946 9 not not RB cord-010092-uftc8inx 6946 10 yet yet RB cord-010092-uftc8inx 6946 11 been be VBN cord-010092-uftc8inx 6946 12 available available JJ cord-010092-uftc8inx 6946 13 at at IN cord-010092-uftc8inx 6946 14 present present NN cord-010092-uftc8inx 6946 15 . . . cord-010092-uftc8inx 6947 1 Therefore therefore RB cord-010092-uftc8inx 6947 2 , , , cord-010092-uftc8inx 6947 3 we -PRON- PRP cord-010092-uftc8inx 6947 4 provided provide VBD cord-010092-uftc8inx 6947 5 a a DT cord-010092-uftc8inx 6947 6 novel novel JJ cord-010092-uftc8inx 6947 7 therapeutic therapeutic JJ cord-010092-uftc8inx 6947 8 approach approach NN cord-010092-uftc8inx 6947 9 for for IN cord-010092-uftc8inx 6947 10 PUD PUD NNP cord-010092-uftc8inx 6947 11 patients patient NNS cord-010092-uftc8inx 6947 12 and and CC cord-010092-uftc8inx 6947 13 observed observe VBD cord-010092-uftc8inx 6947 14 its -PRON- PRP$ cord-010092-uftc8inx 6947 15 effect effect NN cord-010092-uftc8inx 6947 16 in in IN cord-010092-uftc8inx 6947 17 this this DT cord-010092-uftc8inx 6947 18 study study NN cord-010092-uftc8inx 6947 19 . . . cord-010092-uftc8inx 6948 1 Aims aim VBZ cord-010092-uftc8inx 6948 2 : : : cord-010092-uftc8inx 6948 3 We -PRON- PRP cord-010092-uftc8inx 6948 4 provided provide VBD cord-010092-uftc8inx 6948 5 a a DT cord-010092-uftc8inx 6948 6 novel novel JJ cord-010092-uftc8inx 6948 7 therapeutic therapeutic JJ cord-010092-uftc8inx 6948 8 approach approach NN cord-010092-uftc8inx 6948 9 for for IN cord-010092-uftc8inx 6948 10 PUD PUD NNP cord-010092-uftc8inx 6948 11 patients patient NNS cord-010092-uftc8inx 6948 12 and and CC cord-010092-uftc8inx 6948 13 observed observe VBD cord-010092-uftc8inx 6948 14 its -PRON- PRP$ cord-010092-uftc8inx 6948 15 effect effect NN cord-010092-uftc8inx 6948 16 in in IN cord-010092-uftc8inx 6948 17 this this DT cord-010092-uftc8inx 6948 18 study study NN cord-010092-uftc8inx 6948 19 . . . cord-010092-uftc8inx 6949 1 Methods method NNS cord-010092-uftc8inx 6949 2 : : : cord-010092-uftc8inx 6949 3 In in IN cord-010092-uftc8inx 6949 4 this this DT cord-010092-uftc8inx 6949 5 randomized randomized JJ cord-010092-uftc8inx 6949 6 controlled control VBN cord-010092-uftc8inx 6949 7 trial trial NN cord-010092-uftc8inx 6949 8 , , , cord-010092-uftc8inx 6949 9 PUD PUD NNP cord-010092-uftc8inx 6949 10 patients patient NNS cord-010092-uftc8inx 6949 11 residing reside VBG cord-010092-uftc8inx 6949 12 in in IN cord-010092-uftc8inx 6949 13 Chongqing Chongqing NNP cord-010092-uftc8inx 6949 14 were be VBD cord-010092-uftc8inx 6949 15 enrolled enrol VBN cord-010092-uftc8inx 6949 16 from from IN cord-010092-uftc8inx 6949 17 2016 2016 CD cord-010092-uftc8inx 6949 18 to to IN cord-010092-uftc8inx 6949 19 2017 2017 CD cord-010092-uftc8inx 6949 20 . . . cord-010092-uftc8inx 6950 1 They -PRON- PRP cord-010092-uftc8inx 6950 2 were be VBD cord-010092-uftc8inx 6950 3 randomly randomly RB cord-010092-uftc8inx 6950 4 assigned assign VBN cord-010092-uftc8inx 6950 5 to to IN cord-010092-uftc8inx 6950 6 two two CD cord-010092-uftc8inx 6950 7 groups group NNS cord-010092-uftc8inx 6950 8 : : : cord-010092-uftc8inx 6950 9 ( ( -LRB- cord-010092-uftc8inx 6950 10 a a LS cord-010092-uftc8inx 6950 11 ) ) -RRB- cord-010092-uftc8inx 6951 1 a a DT cord-010092-uftc8inx 6951 2 control control NN cord-010092-uftc8inx 6951 3 group group NN cord-010092-uftc8inx 6951 4 used use VBN cord-010092-uftc8inx 6951 5 only only JJ cord-010092-uftc8inx 6951 6 rabeprazole rabeprazole NNP cord-010092-uftc8inx 6951 7 , , , cord-010092-uftc8inx 6951 8 and and CC cord-010092-uftc8inx 6951 9 ( ( -LRB- cord-010092-uftc8inx 6951 10 b b LS cord-010092-uftc8inx 6951 11 ) ) -RRB- cord-010092-uftc8inx 6951 12 a a DT cord-010092-uftc8inx 6951 13 platelet platelet NN cord-010092-uftc8inx 6951 14 - - HYPH cord-010092-uftc8inx 6951 15 rich rich JJ cord-010092-uftc8inx 6951 16 plasma plasma NN cord-010092-uftc8inx 6951 17 ( ( -LRB- cord-010092-uftc8inx 6951 18 PRP prp NN cord-010092-uftc8inx 6951 19 ) ) -RRB- cord-010092-uftc8inx 6951 20 group group NN cord-010092-uftc8inx 6951 21 that that WDT cord-010092-uftc8inx 6951 22 received receive VBD cord-010092-uftc8inx 6951 23 a a DT cord-010092-uftc8inx 6951 24 combined combine VBN cord-010092-uftc8inx 6951 25 therapy therapy NN cord-010092-uftc8inx 6951 26 of of IN cord-010092-uftc8inx 6951 27 autologous autologous JJ cord-010092-uftc8inx 6951 28 platelet platelet NN cord-010092-uftc8inx 6951 29 - - HYPH cord-010092-uftc8inx 6951 30 rich rich JJ cord-010092-uftc8inx 6951 31 plasma plasma NN cord-010092-uftc8inx 6951 32 ( ( -LRB- cord-010092-uftc8inx 6951 33 aPRP aPRP NNP cord-010092-uftc8inx 6951 34 ) ) -RRB- cord-010092-uftc8inx 6951 35 and and CC cord-010092-uftc8inx 6951 36 rabeprazole rabeprazole NNP cord-010092-uftc8inx 6951 37 . . . cord-010092-uftc8inx 6952 1 The the DT cord-010092-uftc8inx 6952 2 aggregation aggregation NN cord-010092-uftc8inx 6952 3 rate rate NN cord-010092-uftc8inx 6952 4 of of IN cord-010092-uftc8inx 6952 5 aPRP aPRP NNP cord-010092-uftc8inx 6952 6 was be VBD cord-010092-uftc8inx 6952 7 measured measure VBN cord-010092-uftc8inx 6952 8 via via IN cord-010092-uftc8inx 6952 9 aggregation aggregation NN cord-010092-uftc8inx 6952 10 remote remote JJ cord-010092-uftc8inx 6952 11 analyzer analyzer NN cord-010092-uftc8inx 6952 12 module module NN cord-010092-uftc8inx 6952 13 . . . cord-010092-uftc8inx 6953 1 The the DT cord-010092-uftc8inx 6953 2 therapeutic therapeutic JJ cord-010092-uftc8inx 6953 3 effect effect NN cord-010092-uftc8inx 6953 4 was be VBD cord-010092-uftc8inx 6953 5 assessed assess VBN cord-010092-uftc8inx 6953 6 via via IN cord-010092-uftc8inx 6953 7 the the DT cord-010092-uftc8inx 6953 8 ulcer ulcer NN cord-010092-uftc8inx 6953 9 size size NN cord-010092-uftc8inx 6953 10 and and CC cord-010092-uftc8inx 6953 11 the the DT cord-010092-uftc8inx 6953 12 symptom symptom NN cord-010092-uftc8inx 6953 13 score score NN cord-010092-uftc8inx 6953 14 . . . cord-010092-uftc8inx 6954 1 All all DT cord-010092-uftc8inx 6954 2 data datum NNS cord-010092-uftc8inx 6954 3 were be VBD cord-010092-uftc8inx 6954 4 recorded record VBN cord-010092-uftc8inx 6954 5 and and CC cord-010092-uftc8inx 6954 6 analyzed analyze VBN cord-010092-uftc8inx 6954 7 statistically statistically RB cord-010092-uftc8inx 6954 8 using use VBG cord-010092-uftc8inx 6954 9 SPSS SPSS NNP cord-010092-uftc8inx 6954 10 . . . cord-010092-uftc8inx 6955 1 Results result NNS cord-010092-uftc8inx 6955 2 : : : cord-010092-uftc8inx 6956 1 A a DT cord-010092-uftc8inx 6956 2 total total NN cord-010092-uftc8inx 6956 3 of of IN cord-010092-uftc8inx 6956 4 27 27 CD cord-010092-uftc8inx 6956 5 patients patient NNS cord-010092-uftc8inx 6956 6 were be VBD cord-010092-uftc8inx 6956 7 included include VBN cord-010092-uftc8inx 6956 8 ( ( -LRB- cord-010092-uftc8inx 6956 9 12 12 CD cord-010092-uftc8inx 6956 10 patients patient NNS cord-010092-uftc8inx 6956 11 as as IN cord-010092-uftc8inx 6956 12 control control NN cord-010092-uftc8inx 6956 13 group group NN cord-010092-uftc8inx 6956 14 ) ) -RRB- cord-010092-uftc8inx 6956 15 and and CC cord-010092-uftc8inx 6956 16 ( ( -LRB- cord-010092-uftc8inx 6956 17 15 15 CD cord-010092-uftc8inx 6956 18 patients patient NNS cord-010092-uftc8inx 6956 19 as as IN cord-010092-uftc8inx 6956 20 PRP PRP NNP cord-010092-uftc8inx 6956 21 group group NN cord-010092-uftc8inx 6956 22 ) ) -RRB- cord-010092-uftc8inx 6956 23 in in IN cord-010092-uftc8inx 6956 24 the the DT cord-010092-uftc8inx 6956 25 analysis analysis NN cord-010092-uftc8inx 6956 26 . . . cord-010092-uftc8inx 6957 1 We -PRON- PRP cord-010092-uftc8inx 6957 2 found find VBD cord-010092-uftc8inx 6957 3 that that IN cord-010092-uftc8inx 6957 4 the the DT cord-010092-uftc8inx 6957 5 aggregation aggregation NN cord-010092-uftc8inx 6957 6 rate rate NN cord-010092-uftc8inx 6957 7 of of IN cord-010092-uftc8inx 6957 8 aPRP aPRP NNP cord-010092-uftc8inx 6957 9 is be VBZ cord-010092-uftc8inx 6957 10 not not RB cord-010092-uftc8inx 6957 11 affected affect VBN cord-010092-uftc8inx 6957 12 in in IN cord-010092-uftc8inx 6957 13 pH pH NNP cord-010092-uftc8inx 6957 14 2.5 2.5 CD cord-010092-uftc8inx 6957 15 after after IN cord-010092-uftc8inx 6957 16 treatment treatment NN cord-010092-uftc8inx 6957 17 with with IN cord-010092-uftc8inx 6957 18 pepsin pepsin NN cord-010092-uftc8inx 6957 19 . . . cord-010092-uftc8inx 6958 1 Our -PRON- PRP$ cord-010092-uftc8inx 6958 2 results result NNS cord-010092-uftc8inx 6958 3 showed show VBD cord-010092-uftc8inx 6958 4 that that IN cord-010092-uftc8inx 6958 5 there there EX cord-010092-uftc8inx 6958 6 were be VBD cord-010092-uftc8inx 6958 7 no no DT cord-010092-uftc8inx 6958 8 significant significant JJ cord-010092-uftc8inx 6958 9 differences difference NNS cord-010092-uftc8inx 6958 10 between between IN cord-010092-uftc8inx 6958 11 the the DT cord-010092-uftc8inx 6958 12 PRP PRP NNP cord-010092-uftc8inx 6958 13 group group NN cord-010092-uftc8inx 6958 14 and and CC cord-010092-uftc8inx 6958 15 control control NN cord-010092-uftc8inx 6958 16 group group NN cord-010092-uftc8inx 6958 17 before before IN cord-010092-uftc8inx 6958 18 the the DT cord-010092-uftc8inx 6958 19 treatment treatment NN cord-010092-uftc8inx 6958 20 , , , cord-010092-uftc8inx 6958 21 and and CC cord-010092-uftc8inx 6958 22 there there EX cord-010092-uftc8inx 6958 23 was be VBD cord-010092-uftc8inx 6958 24 also also RB cord-010092-uftc8inx 6958 25 no no DT cord-010092-uftc8inx 6958 26 significant significant JJ cord-010092-uftc8inx 6958 27 difference difference NN cord-010092-uftc8inx 6958 28 in in IN cord-010092-uftc8inx 6958 29 healing healing NN cord-010092-uftc8inx 6958 30 time time NN cord-010092-uftc8inx 6958 31 between between IN cord-010092-uftc8inx 6958 32 the the DT cord-010092-uftc8inx 6958 33 two two CD cord-010092-uftc8inx 6958 34 groups group NNS cord-010092-uftc8inx 6958 35 in in IN cord-010092-uftc8inx 6958 36 different different JJ cord-010092-uftc8inx 6958 37 variables variable NNS cord-010092-uftc8inx 6958 38 . . . cord-010092-uftc8inx 6959 1 However however RB cord-010092-uftc8inx 6959 2 , , , cord-010092-uftc8inx 6959 3 regression regression NN cord-010092-uftc8inx 6959 4 analysis analysis NN cord-010092-uftc8inx 6959 5 revealed reveal VBD cord-010092-uftc8inx 6959 6 that that IN cord-010092-uftc8inx 6959 7 the the DT cord-010092-uftc8inx 6959 8 healing healing NN cord-010092-uftc8inx 6959 9 time time NN cord-010092-uftc8inx 6959 10 was be VBD cord-010092-uftc8inx 6959 11 6.99 6.99 CD cord-010092-uftc8inx 6959 12 d d XX cord-010092-uftc8inx 6959 13 less less JJR cord-010092-uftc8inx 6959 14 in in IN cord-010092-uftc8inx 6959 15 the the DT cord-010092-uftc8inx 6959 16 PRP PRP NNP cord-010092-uftc8inx 6959 17 group group NN cord-010092-uftc8inx 6959 18 than than IN cord-010092-uftc8inx 6959 19 in in IN cord-010092-uftc8inx 6959 20 the the DT cord-010092-uftc8inx 6959 21 control control NN cord-010092-uftc8inx 6959 22 group group NN cord-010092-uftc8inx 6959 23 , , , cord-010092-uftc8inx 6959 24 and and CC cord-010092-uftc8inx 6959 25 the the DT cord-010092-uftc8inx 6959 26 patients patient NNS cord-010092-uftc8inx 6959 27 with with IN cord-010092-uftc8inx 6959 28 higher high JJR cord-010092-uftc8inx 6959 29 symptom symptom NN cord-010092-uftc8inx 6959 30 scores score NNS cord-010092-uftc8inx 6959 31 in in IN cord-010092-uftc8inx 6959 32 the the DT cord-010092-uftc8inx 6959 33 initial initial JJ cord-010092-uftc8inx 6959 34 examination examination NN cord-010092-uftc8inx 6959 35 need need VBP cord-010092-uftc8inx 6959 36 more more JJR cord-010092-uftc8inx 6959 37 time time NN cord-010092-uftc8inx 6959 38 to to TO cord-010092-uftc8inx 6959 39 heal heal VB cord-010092-uftc8inx 6959 40 in in IN cord-010092-uftc8inx 6959 41 treatment treatment NN cord-010092-uftc8inx 6959 42 . . . cord-010092-uftc8inx 6960 1 Summary Summary NNP cord-010092-uftc8inx 6960 2 / / SYM cord-010092-uftc8inx 6960 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 6960 4 : : : cord-010092-uftc8inx 6961 1 This this DT cord-010092-uftc8inx 6961 2 study study NN cord-010092-uftc8inx 6961 3 showed show VBD cord-010092-uftc8inx 6961 4 an an DT cord-010092-uftc8inx 6961 5 encouraging encouraging JJ cord-010092-uftc8inx 6961 6 preliminary preliminary JJ cord-010092-uftc8inx 6961 7 result result NN cord-010092-uftc8inx 6961 8 that that IN cord-010092-uftc8inx 6961 9 aPRP aPRP `` cord-010092-uftc8inx 6961 10 has have VBZ cord-010092-uftc8inx 6961 11 a a DT cord-010092-uftc8inx 6961 12 positive positive JJ cord-010092-uftc8inx 6961 13 result result NN cord-010092-uftc8inx 6961 14 in in IN cord-010092-uftc8inx 6961 15 the the DT cord-010092-uftc8inx 6961 16 peptic peptic JJ cord-010092-uftc8inx 6961 17 ulcer ulcer NN cord-010092-uftc8inx 6961 18 patients patient NNS cord-010092-uftc8inx 6961 19 , , , cord-010092-uftc8inx 6961 20 and and CC cord-010092-uftc8inx 6961 21 it -PRON- PRP cord-010092-uftc8inx 6961 22 seems seem VBZ cord-010092-uftc8inx 6961 23 to to TO cord-010092-uftc8inx 6961 24 be be VB cord-010092-uftc8inx 6961 25 a a DT cord-010092-uftc8inx 6961 26 better well JJR cord-010092-uftc8inx 6961 27 choice choice NN cord-010092-uftc8inx 6961 28 for for IN cord-010092-uftc8inx 6961 29 refractory refractory JJ cord-010092-uftc8inx 6961 30 PUD PUD NNP cord-010092-uftc8inx 6961 31 patients patient NNS cord-010092-uftc8inx 6961 32 . . . cord-010092-uftc8inx 6962 1 Despite despite IN cord-010092-uftc8inx 6962 2 the the DT cord-010092-uftc8inx 6962 3 further further JJ cord-010092-uftc8inx 6962 4 follow follow NN cord-010092-uftc8inx 6962 5 - - HYPH cord-010092-uftc8inx 6962 6 up up NN cord-010092-uftc8inx 6962 7 studies study NNS cord-010092-uftc8inx 6962 8 are be VBP cord-010092-uftc8inx 6962 9 needed need VBN cord-010092-uftc8inx 6962 10 to to TO cord-010092-uftc8inx 6962 11 determine determine VB cord-010092-uftc8inx 6962 12 the the DT cord-010092-uftc8inx 6962 13 duration duration NN cord-010092-uftc8inx 6962 14 of of IN cord-010092-uftc8inx 6962 15 efficacy efficacy NN cord-010092-uftc8inx 6962 16 of of IN cord-010092-uftc8inx 6962 17 aPRP aPRP NNP cord-010092-uftc8inx 6962 18 , , , cord-010092-uftc8inx 6962 19 the the DT cord-010092-uftc8inx 6962 20 approach approach NN cord-010092-uftc8inx 6962 21 will will MD cord-010092-uftc8inx 6962 22 be be VB cord-010092-uftc8inx 6962 23 helpful helpful JJ cord-010092-uftc8inx 6962 24 for for IN cord-010092-uftc8inx 6962 25 improving improve VBG cord-010092-uftc8inx 6962 26 the the DT cord-010092-uftc8inx 6962 27 PUD PUD NNP cord-010092-uftc8inx 6962 28 treatment treatment NN cord-010092-uftc8inx 6962 29 in in IN cord-010092-uftc8inx 6962 30 clinical clinical JJ cord-010092-uftc8inx 6962 31 . . . cord-010092-uftc8inx 6963 1 Background background NN cord-010092-uftc8inx 6963 2 : : : cord-010092-uftc8inx 6964 1 The the DT cord-010092-uftc8inx 6964 2 Croatian Croatian NNP cord-010092-uftc8inx 6964 3 Institute Institute NNP cord-010092-uftc8inx 6964 4 of of IN cord-010092-uftc8inx 6964 5 Transfusion Transfusion NNP cord-010092-uftc8inx 6964 6 Medicine Medicine NNP cord-010092-uftc8inx 6964 7 ( ( -LRB- cord-010092-uftc8inx 6964 8 CITM CITM NNP cord-010092-uftc8inx 6964 9 ) ) -RRB- cord-010092-uftc8inx 6964 10 collects collect VBZ cord-010092-uftc8inx 6964 11 , , , cord-010092-uftc8inx 6964 12 produces produce VBZ cord-010092-uftc8inx 6964 13 and and CC cord-010092-uftc8inx 6964 14 distributes distribute VBZ cord-010092-uftc8inx 6964 15 blood blood NN cord-010092-uftc8inx 6964 16 components component NNS cord-010092-uftc8inx 6964 17 in in IN cord-010092-uftc8inx 6964 18 an an DT cord-010092-uftc8inx 6964 19 area area NN cord-010092-uftc8inx 6964 20 of of IN cord-010092-uftc8inx 6964 21 4.2 4.2 CD cord-010092-uftc8inx 6964 22 million million CD cord-010092-uftc8inx 6964 23 habitants habitant NNS cord-010092-uftc8inx 6964 24 . . . cord-010092-uftc8inx 6965 1 Annually annually RB cord-010092-uftc8inx 6965 2 , , , cord-010092-uftc8inx 6965 3 it -PRON- PRP cord-010092-uftc8inx 6965 4 collects collect VBZ cord-010092-uftc8inx 6965 5 about about RB cord-010092-uftc8inx 6965 6 100,000 100,000 CD cord-010092-uftc8inx 6965 7 whole whole JJ cord-010092-uftc8inx 6965 8 blood blood NN cord-010092-uftc8inx 6965 9 and and CC cord-010092-uftc8inx 6965 10 3,500 3,500 CD cord-010092-uftc8inx 6965 11 apheresis apheresis NN cord-010092-uftc8inx 6965 12 donations donation NNS cord-010092-uftc8inx 6965 13 . . . cord-010092-uftc8inx 6966 1 Platelet platelet NN cord-010092-uftc8inx 6966 2 concentrates concentrate VBZ cord-010092-uftc8inx 6966 3 ( ( -LRB- cord-010092-uftc8inx 6966 4 PCs pc NNS cord-010092-uftc8inx 6966 5 ) ) -RRB- cord-010092-uftc8inx 6966 6 are be VBP cord-010092-uftc8inx 6966 7 more more RBR cord-010092-uftc8inx 6966 8 inclined inclined JJ cord-010092-uftc8inx 6966 9 to to IN cord-010092-uftc8inx 6966 10 bacterial bacterial JJ cord-010092-uftc8inx 6966 11 contamination contamination NN cord-010092-uftc8inx 6966 12 due due IN cord-010092-uftc8inx 6966 13 to to IN cord-010092-uftc8inx 6966 14 storage storage NN cord-010092-uftc8inx 6966 15 conditions condition NNS cord-010092-uftc8inx 6966 16 that that WDT cord-010092-uftc8inx 6966 17 favor favor VBP cord-010092-uftc8inx 6966 18 bacterial bacterial JJ cord-010092-uftc8inx 6966 19 replication replication NN cord-010092-uftc8inx 6966 20 . . . cord-010092-uftc8inx 6967 1 The the DT cord-010092-uftc8inx 6967 2 CITM CITM NNP cord-010092-uftc8inx 6967 3 decided decide VBD cord-010092-uftc8inx 6967 4 to to TO cord-010092-uftc8inx 6967 5 evaluate evaluate VB cord-010092-uftc8inx 6967 6 the the DT cord-010092-uftc8inx 6967 7 Mirasol Mirasol NNP cord-010092-uftc8inx 6967 8 Pathogen Pathogen NNP cord-010092-uftc8inx 6967 9 Reduction Reduction NNP cord-010092-uftc8inx 6967 10 Technology Technology NNP cord-010092-uftc8inx 6967 11 ( ( -LRB- cord-010092-uftc8inx 6967 12 PRT PRT NNP cord-010092-uftc8inx 6967 13 ) ) -RRB- cord-010092-uftc8inx 6967 14 system system NN cord-010092-uftc8inx 6967 15 as as IN cord-010092-uftc8inx 6967 16 it -PRON- PRP cord-010092-uftc8inx 6967 17 offers offer VBZ cord-010092-uftc8inx 6967 18 the the DT cord-010092-uftc8inx 6967 19 possibility possibility NN cord-010092-uftc8inx 6967 20 to to TO cord-010092-uftc8inx 6967 21 work work VB cord-010092-uftc8inx 6967 22 with with IN cord-010092-uftc8inx 6967 23 a a DT cord-010092-uftc8inx 6967 24 non non JJ cord-010092-uftc8inx 6967 25 - - JJ cord-010092-uftc8inx 6967 26 toxic toxic JJ cord-010092-uftc8inx 6967 27 , , , cord-010092-uftc8inx 6967 28 non non JJ cord-010092-uftc8inx 6967 29 - - JJ cord-010092-uftc8inx 6967 30 mutagenic mutagenic JJ cord-010092-uftc8inx 6967 31 compound compound NN cord-010092-uftc8inx 6967 32 that that IN cord-010092-uftc8inx 6967 33 upon upon IN cord-010092-uftc8inx 6967 34 UV uv NN cord-010092-uftc8inx 6967 35 illumination illumination NN cord-010092-uftc8inx 6967 36 induce induce VB cord-010092-uftc8inx 6967 37 nucleic nucleic JJ cord-010092-uftc8inx 6967 38 acid acid NN cord-010092-uftc8inx 6967 39 damage damage NN cord-010092-uftc8inx 6967 40 , , , cord-010092-uftc8inx 6967 41 reducing reduce VBG cord-010092-uftc8inx 6967 42 the the DT cord-010092-uftc8inx 6967 43 risk risk NN cord-010092-uftc8inx 6967 44 of of IN cord-010092-uftc8inx 6967 45 septic septic JJ cord-010092-uftc8inx 6967 46 transfusion transfusion NN cord-010092-uftc8inx 6967 47 . . . cord-010092-uftc8inx 6968 1 Aims aim VBZ cord-010092-uftc8inx 6968 2 : : : cord-010092-uftc8inx 6969 1 The the DT cord-010092-uftc8inx 6969 2 study study NN cord-010092-uftc8inx 6969 3 objective objective NN cord-010092-uftc8inx 6969 4 was be VBD cord-010092-uftc8inx 6969 5 to to TO cord-010092-uftc8inx 6969 6 evaluate evaluate VB cord-010092-uftc8inx 6969 7 quality quality NN cord-010092-uftc8inx 6969 8 of of IN cord-010092-uftc8inx 6969 9 PCs pc NNS cord-010092-uftc8inx 6969 10 treated treat VBN cord-010092-uftc8inx 6969 11 with with IN cord-010092-uftc8inx 6969 12 the the DT cord-010092-uftc8inx 6969 13 Mirasol Mirasol NNP cord-010092-uftc8inx 6969 14 PRT PRT NNP cord-010092-uftc8inx 6969 15 system system NN cord-010092-uftc8inx 6969 16 for for IN cord-010092-uftc8inx 6969 17 platelets platelet NNS cord-010092-uftc8inx 6969 18 and and CC cord-010092-uftc8inx 6969 19 stored store VBN cord-010092-uftc8inx 6969 20 in in IN cord-010092-uftc8inx 6969 21 TPAS+ tpas+ NN cord-010092-uftc8inx 6969 22 for for IN cord-010092-uftc8inx 6969 23 7 7 CD cord-010092-uftc8inx 6969 24 days day NNS cord-010092-uftc8inx 6969 25 at at IN cord-010092-uftc8inx 6969 26 22 22 CD cord-010092-uftc8inx 6969 27 ° ° NN cord-010092-uftc8inx 6969 28 C c NN cord-010092-uftc8inx 6969 29 on on IN cord-010092-uftc8inx 6969 30 a a DT cord-010092-uftc8inx 6969 31 platelet platelet NN cord-010092-uftc8inx 6969 32 shaker shaker NN cord-010092-uftc8inx 6969 33 . . . cord-010092-uftc8inx 6970 1 Methods method NNS cord-010092-uftc8inx 6970 2 : : : cord-010092-uftc8inx 6970 3 PCs pc NNS cord-010092-uftc8inx 6970 4 were be VBD cord-010092-uftc8inx 6970 5 produced produce VBN cord-010092-uftc8inx 6970 6 according accord VBG cord-010092-uftc8inx 6970 7 to to IN cord-010092-uftc8inx 6970 8 the the DT cord-010092-uftc8inx 6970 9 CITM CITM NNP cord-010092-uftc8inx 6970 10 's 's POS cord-010092-uftc8inx 6970 11 S.O.P. S.O.P. NNP cord-010092-uftc8inx 6970 12 , , , cord-010092-uftc8inx 6970 13 either either CC cord-010092-uftc8inx 6970 14 through through IN cord-010092-uftc8inx 6970 15 pooling pooling NN cord-010092-uftc8inx 6970 16 of of IN cord-010092-uftc8inx 6970 17 4 4 CD cord-010092-uftc8inx 6970 18 BC BC NNP cord-010092-uftc8inx 6970 19 with with IN cord-010092-uftc8inx 6970 20 TPAS+ TPAS+ NNP cord-010092-uftc8inx 6970 21 , , , cord-010092-uftc8inx 6970 22 " " `` cord-010092-uftc8inx 6970 23 WBD WBD NNP cord-010092-uftc8inx 6970 24 " " '' cord-010092-uftc8inx 6970 25 , , , cord-010092-uftc8inx 6970 26 or or CC cord-010092-uftc8inx 6970 27 through through IN cord-010092-uftc8inx 6970 28 apheresis apheresis NN cord-010092-uftc8inx 6970 29 collection collection NN cord-010092-uftc8inx 6970 30 using use VBG cord-010092-uftc8inx 6970 31 two two CD cord-010092-uftc8inx 6970 32 devices device NNS cord-010092-uftc8inx 6970 33 : : : cord-010092-uftc8inx 6970 34 the the DT cord-010092-uftc8inx 6970 35 Fresenius Fresenius NNP cord-010092-uftc8inx 6970 36 Amicus Amicus NNP cord-010092-uftc8inx 6970 37 , , , cord-010092-uftc8inx 6970 38 " " `` cord-010092-uftc8inx 6970 39 AD ad NN cord-010092-uftc8inx 6970 40 " " '' cord-010092-uftc8inx 6970 41 and and CC cord-010092-uftc8inx 6970 42 Haemonetics Haemonetics NNP cord-010092-uftc8inx 6970 43 MCS+ MCS+ NNP cord-010092-uftc8inx 6970 44 System System NNP cord-010092-uftc8inx 6970 45 , , , cord-010092-uftc8inx 6970 46 " " `` cord-010092-uftc8inx 6970 47 MCD MCD NNP cord-010092-uftc8inx 6970 48 " " '' cord-010092-uftc8inx 6970 49 . . . cord-010092-uftc8inx 6971 1 PCs pc NNS cord-010092-uftc8inx 6971 2 were be VBD cord-010092-uftc8inx 6971 3 stored store VBN cord-010092-uftc8inx 6971 4 in in IN cord-010092-uftc8inx 6971 5 33 33 CD cord-010092-uftc8inx 6971 6 % % NN cord-010092-uftc8inx 6971 7 plasma plasma NN cord-010092-uftc8inx 6971 8 and and CC cord-010092-uftc8inx 6971 9 65 65 CD cord-010092-uftc8inx 6971 10 % % NN cord-010092-uftc8inx 6971 11 PAS pas NN cord-010092-uftc8inx 6971 12 and and CC cord-010092-uftc8inx 6971 13 MCD MCD NNP cord-010092-uftc8inx 6971 14 were be VBD cord-010092-uftc8inx 6971 15 subsequently subsequently RB cord-010092-uftc8inx 6971 16 evaluated evaluate VBN cord-010092-uftc8inx 6971 17 also also RB cord-010092-uftc8inx 6971 18 in in IN cord-010092-uftc8inx 6971 19 38 38 CD cord-010092-uftc8inx 6971 20 % % NN cord-010092-uftc8inx 6971 21 of of IN cord-010092-uftc8inx 6971 22 plasma plasma NN cord-010092-uftc8inx 6971 23 and and CC cord-010092-uftc8inx 6971 24 62 62 CD cord-010092-uftc8inx 6971 25 % % NN cord-010092-uftc8inx 6971 26 PAS pas NN cord-010092-uftc8inx 6971 27 . . . cord-010092-uftc8inx 6972 1 Identical identical JJ cord-010092-uftc8inx 6972 2 PCs pc NNS cord-010092-uftc8inx 6972 3 were be VBD cord-010092-uftc8inx 6972 4 produced produce VBN cord-010092-uftc8inx 6972 5 with with IN cord-010092-uftc8inx 6972 6 a a DT cord-010092-uftc8inx 6972 7 pool pool NN cord-010092-uftc8inx 6972 8 - - HYPH cord-010092-uftc8inx 6972 9 split split NN cord-010092-uftc8inx 6972 10 protocol protocol NN cord-010092-uftc8inx 6972 11 to to TO cord-010092-uftc8inx 6972 12 be be VB cord-010092-uftc8inx 6972 13 PRT PRT NNP cord-010092-uftc8inx 6972 14 - - HYPH cord-010092-uftc8inx 6972 15 treated treat VBN cord-010092-uftc8inx 6972 16 or or CC cord-010092-uftc8inx 6972 17 serve serve VBP cord-010092-uftc8inx 6972 18 as as IN cord-010092-uftc8inx 6972 19 untreated untreated JJ cord-010092-uftc8inx 6972 20 control control NN cord-010092-uftc8inx 6972 21 . . . cord-010092-uftc8inx 6973 1 PCs pc NNS cord-010092-uftc8inx 6973 2 were be VBD cord-010092-uftc8inx 6973 3 treated treat VBN cord-010092-uftc8inx 6973 4 with with IN cord-010092-uftc8inx 6973 5 the the DT cord-010092-uftc8inx 6973 6 Mirasol Mirasol NNP cord-010092-uftc8inx 6973 7 system system NN cord-010092-uftc8inx 6973 8 according accord VBG cord-010092-uftc8inx 6973 9 to to IN cord-010092-uftc8inx 6973 10 manufacturer manufacturer NN cord-010092-uftc8inx 6973 11 's 's POS cord-010092-uftc8inx 6973 12 instructions instruction NNS cord-010092-uftc8inx 6973 13 . . . cord-010092-uftc8inx 6974 1 QC QC NNP cord-010092-uftc8inx 6974 2 parameters parameter NNS cord-010092-uftc8inx 6974 3 , , , cord-010092-uftc8inx 6974 4 such such JJ cord-010092-uftc8inx 6974 5 as as IN cord-010092-uftc8inx 6974 6 yield yield NN cord-010092-uftc8inx 6974 7 , , , cord-010092-uftc8inx 6974 8 pH ph NN cord-010092-uftc8inx 6974 9 and and CC cord-010092-uftc8inx 6974 10 swirl swirl NN cord-010092-uftc8inx 6974 11 were be VBD cord-010092-uftc8inx 6974 12 measured measure VBN cord-010092-uftc8inx 6974 13 at at IN cord-010092-uftc8inx 6974 14 days day NNS cord-010092-uftc8inx 6974 15 1 1 CD cord-010092-uftc8inx 6974 16 , , , cord-010092-uftc8inx 6974 17 5 5 CD cord-010092-uftc8inx 6974 18 and and CC cord-010092-uftc8inx 6974 19 7 7 CD cord-010092-uftc8inx 6974 20 . . . cord-010092-uftc8inx 6975 1 Bacteria Bacteria NNS cord-010092-uftc8inx 6975 2 sterility sterility NN cord-010092-uftc8inx 6975 3 test test NN cord-010092-uftc8inx 6975 4 was be VBD cord-010092-uftc8inx 6975 5 performed perform VBN cord-010092-uftc8inx 6975 6 at at IN cord-010092-uftc8inx 6975 7 day day NN cord-010092-uftc8inx 6975 8 7 7 CD cord-010092-uftc8inx 6975 9 for for IN cord-010092-uftc8inx 6975 10 a a DT cord-010092-uftc8inx 6975 11 sample sample NN cord-010092-uftc8inx 6975 12 of of IN cord-010092-uftc8inx 6975 13 all all DT cord-010092-uftc8inx 6975 14 treated treat VBN cord-010092-uftc8inx 6975 15 platelets platelet NNS cord-010092-uftc8inx 6975 16 . . . cord-010092-uftc8inx 6976 1 Protein protein NN cord-010092-uftc8inx 6976 2 content content NN cord-010092-uftc8inx 6976 3 of of IN cord-010092-uftc8inx 6976 4 PCs pc NNS cord-010092-uftc8inx 6976 5 produced produce VBN cord-010092-uftc8inx 6976 6 routinely routinely RB cord-010092-uftc8inx 6976 7 at at IN cord-010092-uftc8inx 6976 8 the the DT cord-010092-uftc8inx 6976 9 CITM CITM NNP cord-010092-uftc8inx 6976 10 was be VBD cord-010092-uftc8inx 6976 11 determined determine VBN cord-010092-uftc8inx 6976 12 to to TO cord-010092-uftc8inx 6976 13 assess assess VB cord-010092-uftc8inx 6976 14 accuracy accuracy NN cord-010092-uftc8inx 6976 15 of of IN cord-010092-uftc8inx 6976 16 plasma plasma NN cord-010092-uftc8inx 6976 17 carry carry NN cord-010092-uftc8inx 6976 18 - - HYPH cord-010092-uftc8inx 6976 19 over over RP cord-010092-uftc8inx 6976 20 calculations calculation NNS cord-010092-uftc8inx 6976 21 for for IN cord-010092-uftc8inx 6976 22 all all DT cord-010092-uftc8inx 6976 23 processed process VBN cord-010092-uftc8inx 6976 24 PCs pc NNS cord-010092-uftc8inx 6976 25 . . . cord-010092-uftc8inx 6977 1 Results result NNS cord-010092-uftc8inx 6977 2 : : : cord-010092-uftc8inx 6978 1 Mirasol Mirasol NNP cord-010092-uftc8inx 6978 2 - - HYPH cord-010092-uftc8inx 6978 3 treated treat VBN cord-010092-uftc8inx 6978 4 WBD WBD NNP cord-010092-uftc8inx 6978 5 ( ( -LRB- cord-010092-uftc8inx 6978 6 n n NN cord-010092-uftc8inx 6978 7 = = SYM cord-010092-uftc8inx 6978 8 10 10 CD cord-010092-uftc8inx 6978 9 ) ) -RRB- cord-010092-uftc8inx 6978 10 and and CC cord-010092-uftc8inx 6978 11 AD ad NN cord-010092-uftc8inx 6978 12 PCs pc NNS cord-010092-uftc8inx 6978 13 ( ( -LRB- cord-010092-uftc8inx 6978 14 n n NN cord-010092-uftc8inx 6978 15 = = SYM cord-010092-uftc8inx 6978 16 8) 8) NN cord-010092-uftc8inx 6978 17 stored store VBN cord-010092-uftc8inx 6978 18 in in IN cord-010092-uftc8inx 6978 19 33 33 CD cord-010092-uftc8inx 6978 20 % % NN cord-010092-uftc8inx 6978 21 plasma plasma NN cord-010092-uftc8inx 6978 22 showed show VBD cord-010092-uftc8inx 6978 23 at at IN cord-010092-uftc8inx 6978 24 day day NN cord-010092-uftc8inx 6978 25 7 7 CD cord-010092-uftc8inx 6978 26 an an DT cord-010092-uftc8inx 6978 27 average average JJ cord-010092-uftc8inx 6978 28 pH ph NN cord-010092-uftc8inx 6978 29 ≥ ≥ CD cord-010092-uftc8inx 6978 30 6.9 6.9 CD cord-010092-uftc8inx 6978 31 ; ; : cord-010092-uftc8inx 6978 32 swirl swirl VBP cord-010092-uftc8inx 6978 33 ≥ ≥ CD cord-010092-uftc8inx 6978 34 2.5 2.5 CD cord-010092-uftc8inx 6978 35 and and CC cord-010092-uftc8inx 6978 36 yield yield VB cord-010092-uftc8inx 6978 37 = = SYM cord-010092-uftc8inx 6978 38 3.3 3.3 CD cord-010092-uftc8inx 6978 39 9 9 CD cord-010092-uftc8inx 6978 40 10 10 CD cord-010092-uftc8inx 6978 41 11 11 CD cord-010092-uftc8inx 6978 42 . . . cord-010092-uftc8inx 6979 1 Their -PRON- PRP$ cord-010092-uftc8inx 6979 2 untreated untreated JJ cord-010092-uftc8inx 6979 3 counterparts counterpart NNS cord-010092-uftc8inx 6979 4 showed show VBD cord-010092-uftc8inx 6979 5 average average JJ cord-010092-uftc8inx 6979 6 values value NNS cord-010092-uftc8inx 6979 7 for for IN cord-010092-uftc8inx 6979 8 pH ph NN cord-010092-uftc8inx 6979 9 ≥ ≥ CD cord-010092-uftc8inx 6979 10 7:0 7:0 NNP cord-010092-uftc8inx 6979 11 , , , cord-010092-uftc8inx 6979 12 swirl swirl VBP cord-010092-uftc8inx 6979 13 ≥ ≥ CD cord-010092-uftc8inx 6979 14 2.9 2.9 CD cord-010092-uftc8inx 6979 15 and and CC cord-010092-uftc8inx 6979 16 yield yield VB cord-010092-uftc8inx 6979 17 3.3 3.3 CD cord-010092-uftc8inx 6979 18 - - SYM cord-010092-uftc8inx 6979 19 3.4 3.4 CD cord-010092-uftc8inx 6979 20 9 9 CD cord-010092-uftc8inx 6979 21 10 10 CD cord-010092-uftc8inx 6979 22 11 11 CD cord-010092-uftc8inx 6979 23 . . . cord-010092-uftc8inx 6980 1 MCD MCD NNP cord-010092-uftc8inx 6980 2 stored store VBD cord-010092-uftc8inx 6980 3 in in IN cord-010092-uftc8inx 6980 4 33 33 CD cord-010092-uftc8inx 6980 5 % % NN cord-010092-uftc8inx 6980 6 plasma plasma NN cord-010092-uftc8inx 6980 7 ( ( -LRB- cord-010092-uftc8inx 6980 8 n n NN cord-010092-uftc8inx 6980 9 = = SYM cord-010092-uftc8inx 6980 10 6 6 CD cord-010092-uftc8inx 6980 11 ) ) -RRB- cord-010092-uftc8inx 6980 12 that that WDT cord-010092-uftc8inx 6980 13 underwent undergo VBD cord-010092-uftc8inx 6980 14 PRT PRT NNP cord-010092-uftc8inx 6980 15 showed show VBD cord-010092-uftc8inx 6980 16 at at IN cord-010092-uftc8inx 6980 17 day day NN cord-010092-uftc8inx 6980 18 7 7 CD cord-010092-uftc8inx 6980 19 average average JJ cord-010092-uftc8inx 6980 20 values value NNS cord-010092-uftc8inx 6980 21 for for IN cord-010092-uftc8inx 6980 22 pH ph NN cord-010092-uftc8inx 6980 23 = = SYM cord-010092-uftc8inx 6980 24 6.7 6.7 CD cord-010092-uftc8inx 6980 25 , , , cord-010092-uftc8inx 6980 26 swirl swirl VBP cord-010092-uftc8inx 6980 27 = = SYM cord-010092-uftc8inx 6980 28 1.2 1.2 CD cord-010092-uftc8inx 6980 29 and and CC cord-010092-uftc8inx 6980 30 yield yield VB cord-010092-uftc8inx 6980 31 = = SYM cord-010092-uftc8inx 6980 32 3.05 3.05 CD cord-010092-uftc8inx 6980 33 . . . cord-010092-uftc8inx 6981 1 Control Control NNP cord-010092-uftc8inx 6981 2 MCD MCD NNP cord-010092-uftc8inx 6981 3 showed show VBD cord-010092-uftc8inx 6981 4 average average JJ cord-010092-uftc8inx 6981 5 values value NNS cord-010092-uftc8inx 6981 6 for for IN cord-010092-uftc8inx 6981 7 pH pH NNP cord-010092-uftc8inx 6981 8 = = NNP cord-010092-uftc8inx 6981 9 7.0 7.0 CD cord-010092-uftc8inx 6981 10 , , , cord-010092-uftc8inx 6981 11 swirl swirl VBP cord-010092-uftc8inx 6981 12 = = SYM cord-010092-uftc8inx 6981 13 2.8 2.8 CD cord-010092-uftc8inx 6981 14 and and CC cord-010092-uftc8inx 6981 15 yield yield NN cord-010092-uftc8inx 6981 16 = = SYM cord-010092-uftc8inx 6981 17 3.1 3.1 CD cord-010092-uftc8inx 6981 18 9 9 CD cord-010092-uftc8inx 6981 19 10 10 CD cord-010092-uftc8inx 6981 20 11 11 CD cord-010092-uftc8inx 6981 21 . . . cord-010092-uftc8inx 6982 1 MCD MCD NNP cord-010092-uftc8inx 6982 2 stored store VBD cord-010092-uftc8inx 6982 3 in in IN cord-010092-uftc8inx 6982 4 38 38 CD cord-010092-uftc8inx 6982 5 % % NN cord-010092-uftc8inx 6982 6 plasma plasma NN cord-010092-uftc8inx 6982 7 ( ( -LRB- cord-010092-uftc8inx 6982 8 n n NN cord-010092-uftc8inx 6982 9 = = SYM cord-010092-uftc8inx 6982 10 8) 8) NN cord-010092-uftc8inx 6982 11 that that WDT cord-010092-uftc8inx 6982 12 underwent undergo VBD cord-010092-uftc8inx 6982 13 PRT PRT NNP cord-010092-uftc8inx 6983 1 showed show VBD cord-010092-uftc8inx 6983 2 average average JJ cord-010092-uftc8inx 6983 3 values value NNS cord-010092-uftc8inx 6983 4 for for IN cord-010092-uftc8inx 6983 5 pH ph NN cord-010092-uftc8inx 6983 6 = = NNP cord-010092-uftc8inx 6983 7 6.6 6.6 CD cord-010092-uftc8inx 6983 8 . . . cord-010092-uftc8inx 6984 1 , , , cord-010092-uftc8inx 6984 2 swirl swirl VB cord-010092-uftc8inx 6984 3 = = SYM cord-010092-uftc8inx 6984 4 1 1 CD cord-010092-uftc8inx 6984 5 and and CC cord-010092-uftc8inx 6984 6 yield yield NN cord-010092-uftc8inx 6984 7 = = SYM cord-010092-uftc8inx 6984 8 3.1 3.1 CD cord-010092-uftc8inx 6984 9 . . . cord-010092-uftc8inx 6985 1 Their -PRON- PRP$ cord-010092-uftc8inx 6985 2 untreated untreated JJ cord-010092-uftc8inx 6985 3 counterparts counterpart NNS cord-010092-uftc8inx 6985 4 had have VBD cord-010092-uftc8inx 6985 5 average average JJ cord-010092-uftc8inx 6985 6 pH ph NN cord-010092-uftc8inx 6985 7 = = NN cord-010092-uftc8inx 6985 8 7.1 7.1 CD cord-010092-uftc8inx 6985 9 , , , cord-010092-uftc8inx 6985 10 swirl swirl NN cord-010092-uftc8inx 6985 11 = = SYM cord-010092-uftc8inx 6985 12 2.9 2.9 CD cord-010092-uftc8inx 6985 13 and and CC cord-010092-uftc8inx 6985 14 yield yield NN cord-010092-uftc8inx 6985 15 = = SYM cord-010092-uftc8inx 6985 16 3.2 3.2 CD cord-010092-uftc8inx 6985 17 . . . cord-010092-uftc8inx 6986 1 Total total JJ cord-010092-uftc8inx 6986 2 protein protein NN cord-010092-uftc8inx 6986 3 content content NN cord-010092-uftc8inx 6986 4 in in IN cord-010092-uftc8inx 6986 5 PCs pc NNS cord-010092-uftc8inx 6986 6 derived derive VBN cord-010092-uftc8inx 6986 7 from from IN cord-010092-uftc8inx 6986 8 WBD WBD NNP cord-010092-uftc8inx 6986 9 ( ( -LRB- cord-010092-uftc8inx 6986 10 n n NN cord-010092-uftc8inx 6986 11 = = SYM cord-010092-uftc8inx 6986 12 12 12 CD cord-010092-uftc8inx 6986 13 ) ) -RRB- cord-010092-uftc8inx 6986 14 , , , cord-010092-uftc8inx 6986 15 AD ad NN cord-010092-uftc8inx 6986 16 ( ( -LRB- cord-010092-uftc8inx 6986 17 n n NN cord-010092-uftc8inx 6986 18 = = SYM cord-010092-uftc8inx 6986 19 15 15 CD cord-010092-uftc8inx 6986 20 ) ) -RRB- cord-010092-uftc8inx 6986 21 and and CC cord-010092-uftc8inx 6986 22 MCD MCD NNP cord-010092-uftc8inx 6986 23 ( ( -LRB- cord-010092-uftc8inx 6986 24 n n NN cord-010092-uftc8inx 6986 25 = = SYM cord-010092-uftc8inx 6986 26 27 27 CD cord-010092-uftc8inx 6986 27 ) ) -RRB- cord-010092-uftc8inx 6986 28 was be VBD cord-010092-uftc8inx 6986 29 22 22 CD cord-010092-uftc8inx 6986 30 g g NN cord-010092-uftc8inx 6986 31 / / SYM cord-010092-uftc8inx 6986 32 L L NNP cord-010092-uftc8inx 6986 33 , , , cord-010092-uftc8inx 6986 34 20 20 CD cord-010092-uftc8inx 6986 35 g g NN cord-010092-uftc8inx 6986 36 / / SYM cord-010092-uftc8inx 6986 37 L L NNP cord-010092-uftc8inx 6986 38 and and CC cord-010092-uftc8inx 6986 39 20 20 CD cord-010092-uftc8inx 6986 40 g g NN cord-010092-uftc8inx 6986 41 / / SYM cord-010092-uftc8inx 6986 42 L L NNP cord-010092-uftc8inx 6986 43 , , , cord-010092-uftc8inx 6986 44 respectively respectively RB cord-010092-uftc8inx 6986 45 . . . cord-010092-uftc8inx 6987 1 While while IN cord-010092-uftc8inx 6987 2 the the DT cord-010092-uftc8inx 6987 3 coefficient coefficient NN cord-010092-uftc8inx 6987 4 of of IN cord-010092-uftc8inx 6987 5 variation variation NN cord-010092-uftc8inx 6987 6 of of IN cord-010092-uftc8inx 6987 7 WBD WBD NNP cord-010092-uftc8inx 6987 8 and and CC cord-010092-uftc8inx 6987 9 AD ad NN cord-010092-uftc8inx 6987 10 ranged range VBD cord-010092-uftc8inx 6987 11 from from IN cord-010092-uftc8inx 6987 12 3 3 CD cord-010092-uftc8inx 6987 13 % % NN cord-010092-uftc8inx 6987 14 to to TO cord-010092-uftc8inx 6987 15 4 4 CD cord-010092-uftc8inx 6987 16 % % NN cord-010092-uftc8inx 6987 17 , , , cord-010092-uftc8inx 6987 18 Plasma plasma NN cord-010092-uftc8inx 6987 19 products product NNS cord-010092-uftc8inx 6987 20 129 129 CD cord-010092-uftc8inx 6987 21 respectively respectively RB cord-010092-uftc8inx 6987 22 , , , cord-010092-uftc8inx 6987 23 the the DT cord-010092-uftc8inx 6987 24 one one CD cord-010092-uftc8inx 6987 25 of of IN cord-010092-uftc8inx 6987 26 MCD MCD NNP cord-010092-uftc8inx 6987 27 reached reach VBD cord-010092-uftc8inx 6987 28 14 14 CD cord-010092-uftc8inx 6987 29 % % NN cord-010092-uftc8inx 6987 30 . . . cord-010092-uftc8inx 6988 1 All all DT cord-010092-uftc8inx 6988 2 PRT PRT NNP cord-010092-uftc8inx 6988 3 - - HYPH cord-010092-uftc8inx 6988 4 PCs pc NNS cord-010092-uftc8inx 6988 5 were be VBD cord-010092-uftc8inx 6988 6 negative negative JJ cord-010092-uftc8inx 6988 7 for for IN cord-010092-uftc8inx 6988 8 bacterial bacterial JJ cord-010092-uftc8inx 6988 9 growth growth NN cord-010092-uftc8inx 6988 10 at at IN cord-010092-uftc8inx 6988 11 day day NN cord-010092-uftc8inx 6988 12 7 7 CD cord-010092-uftc8inx 6988 13 . . . cord-010092-uftc8inx 6989 1 Summary Summary NNP cord-010092-uftc8inx 6989 2 / / SYM cord-010092-uftc8inx 6989 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 6989 4 : : : cord-010092-uftc8inx 6990 1 Mirasol Mirasol NNP cord-010092-uftc8inx 6990 2 treated treat VBD cord-010092-uftc8inx 6990 3 WBD WBD NNP cord-010092-uftc8inx 6990 4 and and CC cord-010092-uftc8inx 6990 5 AD ad NN cord-010092-uftc8inx 6990 6 produced produce VBN cord-010092-uftc8inx 6990 7 according accord VBG cord-010092-uftc8inx 6990 8 to to IN cord-010092-uftc8inx 6990 9 CITM CITM NNP cord-010092-uftc8inx 6990 10 current current JJ cord-010092-uftc8inx 6990 11 S.O.P. S.O.P. NNP cord-010092-uftc8inx 6990 12 were be VBD cord-010092-uftc8inx 6990 13 quite quite RB cord-010092-uftc8inx 6990 14 similar similar JJ cord-010092-uftc8inx 6990 15 to to IN cord-010092-uftc8inx 6990 16 untreated untreated JJ cord-010092-uftc8inx 6990 17 controls control NNS cord-010092-uftc8inx 6990 18 at at IN cord-010092-uftc8inx 6990 19 expiry expiry NN cord-010092-uftc8inx 6990 20 , , , cord-010092-uftc8inx 6990 21 on on IN cord-010092-uftc8inx 6990 22 day day NN cord-010092-uftc8inx 6990 23 7 7 CD cord-010092-uftc8inx 6990 24 and and CC cord-010092-uftc8inx 6990 25 passed pass VBD cord-010092-uftc8inx 6990 26 the the DT cord-010092-uftc8inx 6990 27 requirements requirement NNS cord-010092-uftc8inx 6990 28 of of IN cord-010092-uftc8inx 6990 29 the the DT cord-010092-uftc8inx 6990 30 EU EU NNP cord-010092-uftc8inx 6990 31 guidelines guideline NNS cord-010092-uftc8inx 6990 32 ( ( -LRB- cord-010092-uftc8inx 6990 33 19 19 CD cord-010092-uftc8inx 6990 34 th th XX cord-010092-uftc8inx 6990 35 edition edition NN cord-010092-uftc8inx 6990 36 ) ) -RRB- cord-010092-uftc8inx 6990 37 . . . cord-010092-uftc8inx 6991 1 Quality quality NN cord-010092-uftc8inx 6991 2 of of IN cord-010092-uftc8inx 6991 3 MCD MCD NNP cord-010092-uftc8inx 6991 4 units unit NNS cord-010092-uftc8inx 6991 5 met meet VBD cord-010092-uftc8inx 6991 6 EU EU NNP cord-010092-uftc8inx 6991 7 criteria criterion NNS cord-010092-uftc8inx 6991 8 at at IN cord-010092-uftc8inx 6991 9 day day NN cord-010092-uftc8inx 6991 10 5 5 CD cord-010092-uftc8inx 6991 11 ; ; : cord-010092-uftc8inx 6991 12 swirl swirl NN cord-010092-uftc8inx 6991 13 decreased decrease VBD cord-010092-uftc8inx 6991 14 significantly significantly RB cord-010092-uftc8inx 6991 15 at at IN cord-010092-uftc8inx 6991 16 day day NN cord-010092-uftc8inx 6991 17 7 7 CD cord-010092-uftc8inx 6991 18 which which WDT cord-010092-uftc8inx 6991 19 might may MD cord-010092-uftc8inx 6991 20 be be VB cord-010092-uftc8inx 6991 21 explained explain VBN cord-010092-uftc8inx 6991 22 by by IN cord-010092-uftc8inx 6991 23 the the DT cord-010092-uftc8inx 6991 24 variability variability NN cord-010092-uftc8inx 6991 25 in in IN cord-010092-uftc8inx 6991 26 plasma plasma NN cord-010092-uftc8inx 6991 27 content content NN cord-010092-uftc8inx 6991 28 of of IN cord-010092-uftc8inx 6991 29 MCS+ MCS+ NNP cord-010092-uftc8inx 6991 30 -derived -derived JJ cord-010092-uftc8inx 6991 31 platelets platelet NNS cord-010092-uftc8inx 6991 32 , , , cord-010092-uftc8inx 6991 33 challenging challenge VBG cord-010092-uftc8inx 6991 34 the the DT cord-010092-uftc8inx 6991 35 accurate accurate JJ cord-010092-uftc8inx 6991 36 calculation calculation NN cord-010092-uftc8inx 6991 37 of of IN cord-010092-uftc8inx 6991 38 illumination illumination NN cord-010092-uftc8inx 6991 39 index index NN cord-010092-uftc8inx 6991 40 for for IN cord-010092-uftc8inx 6991 41 the the DT cord-010092-uftc8inx 6991 42 Mirasol Mirasol NNP cord-010092-uftc8inx 6991 43 treatment treatment NN cord-010092-uftc8inx 6991 44 . . . cord-010092-uftc8inx 6992 1 All all DT cord-010092-uftc8inx 6992 2 Mirasol Mirasol NNP cord-010092-uftc8inx 6992 3 treated treat VBD cord-010092-uftc8inx 6992 4 PCs pc NNS cord-010092-uftc8inx 6992 5 showed show VBD cord-010092-uftc8inx 6992 6 minimal minimal JJ cord-010092-uftc8inx 6992 7 platelet platelet NN cord-010092-uftc8inx 6992 8 loss loss NN cord-010092-uftc8inx 6992 9 at at IN cord-010092-uftc8inx 6992 10 the the DT cord-010092-uftc8inx 6992 11 end end NN cord-010092-uftc8inx 6992 12 of of IN cord-010092-uftc8inx 6992 13 storage storage NN cord-010092-uftc8inx 6992 14 . . . cord-010092-uftc8inx 6993 1 As as IN cord-010092-uftc8inx 6993 2 the the DT cord-010092-uftc8inx 6993 3 implementation implementation NN cord-010092-uftc8inx 6993 4 of of IN cord-010092-uftc8inx 6993 5 PR PR NNP cord-010092-uftc8inx 6993 6 had have VBD cord-010092-uftc8inx 6993 7 to to TO cord-010092-uftc8inx 6993 8 be be VB cord-010092-uftc8inx 6993 9 cost cost NN cord-010092-uftc8inx 6993 10 - - HYPH cord-010092-uftc8inx 6993 11 neutral neutral JJ cord-010092-uftc8inx 6993 12 it -PRON- PRP cord-010092-uftc8inx 6993 13 could could MD cord-010092-uftc8inx 6993 14 only only RB cord-010092-uftc8inx 6993 15 be be VB cord-010092-uftc8inx 6993 16 implemented implement VBN cord-010092-uftc8inx 6993 17 for~25 for~25 CD cord-010092-uftc8inx 6993 18 % % NN cord-010092-uftc8inx 6993 19 of of IN cord-010092-uftc8inx 6993 20 the the DT cord-010092-uftc8inx 6993 21 annual annual JJ cord-010092-uftc8inx 6993 22 produced produce VBN cord-010092-uftc8inx 6993 23 buffy buffy NNP cord-010092-uftc8inx 6993 24 coat coat NNP cord-010092-uftc8inx 6993 25 platelet platelet NN cord-010092-uftc8inx 6993 26 concentrates concentrate VBZ cord-010092-uftc8inx 6993 27 ( ( -LRB- cord-010092-uftc8inx 6993 28 BCP BCP NNP cord-010092-uftc8inx 6993 29 ) ) -RRB- cord-010092-uftc8inx 6993 30 ( ( -LRB- cord-010092-uftc8inx 6994 1 ~40.000 ~40.000 NFP cord-010092-uftc8inx 6994 2 BCP BCP NNP cord-010092-uftc8inx 6994 3 / / SYM cord-010092-uftc8inx 6994 4 year year NN cord-010092-uftc8inx 6994 5 ) ) -RRB- cord-010092-uftc8inx 6994 6 and and CC cord-010092-uftc8inx 6994 7 required require VBD cord-010092-uftc8inx 6994 8 a a DT cord-010092-uftc8inx 6994 9 change change NN cord-010092-uftc8inx 6994 10 in in IN cord-010092-uftc8inx 6994 11 the the DT cord-010092-uftc8inx 6994 12 BCP BCP NNP cord-010092-uftc8inx 6994 13 production production NN cord-010092-uftc8inx 6994 14 method method NN cord-010092-uftc8inx 6994 15 . . . cord-010092-uftc8inx 6995 1 The the DT cord-010092-uftc8inx 6995 2 primary primary JJ cord-010092-uftc8inx 6995 3 aim aim NN cord-010092-uftc8inx 6995 4 of of IN cord-010092-uftc8inx 6995 5 the the DT cord-010092-uftc8inx 6995 6 implementation implementation NN cord-010092-uftc8inx 6995 7 was be VBD cord-010092-uftc8inx 6995 8 to to TO cord-010092-uftc8inx 6995 9 offer offer VB cord-010092-uftc8inx 6995 10 increased increase VBN cord-010092-uftc8inx 6995 11 blood blood NN cord-010092-uftc8inx 6995 12 safety safety NN cord-010092-uftc8inx 6995 13 to to IN cord-010092-uftc8inx 6995 14 our -PRON- PRP$ cord-010092-uftc8inx 6995 15 most most RBS cord-010092-uftc8inx 6995 16 vulnerable vulnerable JJ cord-010092-uftc8inx 6995 17 patients patient NNS cord-010092-uftc8inx 6995 18 . . . cord-010092-uftc8inx 6996 1 The the DT cord-010092-uftc8inx 6996 2 secondary secondary JJ cord-010092-uftc8inx 6996 3 aim aim NN cord-010092-uftc8inx 6996 4 was be VBD cord-010092-uftc8inx 6996 5 to to TO cord-010092-uftc8inx 6996 6 ensure ensure VB cord-010092-uftc8inx 6996 7 that that IN cord-010092-uftc8inx 6996 8 we -PRON- PRP cord-010092-uftc8inx 6996 9 built build VBD cord-010092-uftc8inx 6996 10 - - HYPH cord-010092-uftc8inx 6996 11 up up RP cord-010092-uftc8inx 6996 12 enough enough JJ cord-010092-uftc8inx 6996 13 routine routine JJ cord-010092-uftc8inx 6996 14 experience experience NN cord-010092-uftc8inx 6996 15 with with IN cord-010092-uftc8inx 6996 16 PR PR NNP cord-010092-uftc8inx 6996 17 to to TO cord-010092-uftc8inx 6996 18 enable enable VB cord-010092-uftc8inx 6996 19 us -PRON- PRP cord-010092-uftc8inx 6996 20 to to TO cord-010092-uftc8inx 6996 21 quickly quickly RB cord-010092-uftc8inx 6996 22 ramp ramp VB cord-010092-uftc8inx 6996 23 - - HYPH cord-010092-uftc8inx 6996 24 up up RP cord-010092-uftc8inx 6996 25 the the DT cord-010092-uftc8inx 6996 26 production production NN cord-010092-uftc8inx 6996 27 of of IN cord-010092-uftc8inx 6996 28 PR PR NNP cord-010092-uftc8inx 6996 29 - - HYPH cord-010092-uftc8inx 6996 30 BCP BCP NNP cord-010092-uftc8inx 6996 31 to to IN cord-010092-uftc8inx 6996 32 100 100 CD cord-010092-uftc8inx 6996 33 % % NN cord-010092-uftc8inx 6996 34 if if IN cord-010092-uftc8inx 6996 35 there there EX cord-010092-uftc8inx 6996 36 were be VBD cord-010092-uftc8inx 6996 37 an an DT cord-010092-uftc8inx 6996 38 outbreak outbreak NN cord-010092-uftc8inx 6996 39 of of IN cord-010092-uftc8inx 6996 40 an an DT cord-010092-uftc8inx 6996 41 emergent emergent JJ cord-010092-uftc8inx 6996 42 pathogen pathogen NN cord-010092-uftc8inx 6996 43 in in IN cord-010092-uftc8inx 6996 44 the the DT cord-010092-uftc8inx 6996 45 Madrid Madrid NNP cord-010092-uftc8inx 6996 46 region region NN cord-010092-uftc8inx 6996 47 . . . cord-010092-uftc8inx 6997 1 Aims aim VBZ cord-010092-uftc8inx 6997 2 : : : cord-010092-uftc8inx 6998 1 To to TO cord-010092-uftc8inx 6998 2 verify verify VB cord-010092-uftc8inx 6998 3 if if IN cord-010092-uftc8inx 6998 4 we -PRON- PRP cord-010092-uftc8inx 6998 5 could could MD cord-010092-uftc8inx 6998 6 produce~25 produce~25 VB cord-010092-uftc8inx 6998 7 % % NN cord-010092-uftc8inx 6998 8 PR pr NN cord-010092-uftc8inx 6998 9 - - HYPH cord-010092-uftc8inx 6998 10 BCP BCP NNP cord-010092-uftc8inx 6998 11 without without IN cord-010092-uftc8inx 6998 12 increasing increase VBG cord-010092-uftc8inx 6998 13 the the DT cord-010092-uftc8inx 6998 14 overall overall JJ cord-010092-uftc8inx 6998 15 production production NN cord-010092-uftc8inx 6998 16 cost cost NN cord-010092-uftc8inx 6998 17 ( ( -LRB- cord-010092-uftc8inx 6998 18 OPC OPC NNP cord-010092-uftc8inx 6998 19 ) ) -RRB- cord-010092-uftc8inx 6998 20 for for IN cord-010092-uftc8inx 6998 21 BCP BCP NNP cord-010092-uftc8inx 6998 22 . . . cord-010092-uftc8inx 6999 1 Also also RB cord-010092-uftc8inx 6999 2 evaluate evaluate VB cord-010092-uftc8inx 6999 3 the the DT cord-010092-uftc8inx 6999 4 impact impact NN cord-010092-uftc8inx 6999 5 of of IN cord-010092-uftc8inx 6999 6 PR PR NNP cord-010092-uftc8inx 6999 7 on on IN cord-010092-uftc8inx 6999 8 overall overall JJ cord-010092-uftc8inx 6999 9 scrap scrap NN cord-010092-uftc8inx 6999 10 rates rate NNS cord-010092-uftc8inx 6999 11 of of IN cord-010092-uftc8inx 6999 12 BCP BCP NNP cord-010092-uftc8inx 6999 13 , , , cord-010092-uftc8inx 6999 14 outdate outdate JJ cord-010092-uftc8inx 6999 15 rates rate NNS cord-010092-uftc8inx 6999 16 and and CC cord-010092-uftc8inx 6999 17 usage usage NN cord-010092-uftc8inx 6999 18 of of IN cord-010092-uftc8inx 6999 19 other other JJ cord-010092-uftc8inx 6999 20 safety safety NN cord-010092-uftc8inx 6999 21 measures measure NNS cord-010092-uftc8inx 6999 22 . . . cord-010092-uftc8inx 7000 1 Methods method NNS cord-010092-uftc8inx 7000 2 : : : cord-010092-uftc8inx 7000 3 We -PRON- PRP cord-010092-uftc8inx 7000 4 compared compare VBD cord-010092-uftc8inx 7000 5 OPC OPC NNP cord-010092-uftc8inx 7000 6 for for IN cord-010092-uftc8inx 7000 7 BCP BCP NNP cord-010092-uftc8inx 7000 8 between between IN cord-010092-uftc8inx 7000 9 the the DT cord-010092-uftc8inx 7000 10 pre pre JJ cord-010092-uftc8inx 7000 11 - - JJ cord-010092-uftc8inx 7000 12 PR pr JJ cord-010092-uftc8inx 7000 13 period period NN cord-010092-uftc8inx 7000 14 ( ( -LRB- cord-010092-uftc8inx 7000 15 2017 2017 CD cord-010092-uftc8inx 7000 16 ) ) -RRB- cord-010092-uftc8inx 7000 17 . . . cord-010092-uftc8inx 7001 1 This this DT cord-010092-uftc8inx 7001 2 cost cost NN cord-010092-uftc8inx 7001 3 was be VBD cord-010092-uftc8inx 7001 4 offset offset VBN cord-010092-uftc8inx 7001 5 by by IN cord-010092-uftc8inx 7001 6 substituting substitute VBG cord-010092-uftc8inx 7001 7 a a DT cord-010092-uftc8inx 7001 8 semi semi RB cord-010092-uftc8inx 7001 9 - - JJ cord-010092-uftc8inx 7001 10 automated automated JJ cord-010092-uftc8inx 7001 11 production production NN cord-010092-uftc8inx 7001 12 method method NN cord-010092-uftc8inx 7001 13 for for IN cord-010092-uftc8inx 7001 14 BCP BCP NNP cord-010092-uftc8inx 7001 15 , , , cord-010092-uftc8inx 7001 16 which which WDT cord-010092-uftc8inx 7001 17 was be VBD cord-010092-uftc8inx 7001 18 used use VBN cord-010092-uftc8inx 7001 19 in in IN cord-010092-uftc8inx 7001 20 2017 2017 CD cord-010092-uftc8inx 7001 21 to to TO cord-010092-uftc8inx 7001 22 produce produce VB cord-010092-uftc8inx 7001 23 28.7 28.7 CD cord-010092-uftc8inx 7001 24 % % NN cord-010092-uftc8inx 7001 25 of of IN cord-010092-uftc8inx 7001 26 BCP BCP NNP cord-010092-uftc8inx 7001 27 - - HYPH cord-010092-uftc8inx 7001 28 units unit NNS cord-010092-uftc8inx 7001 29 . . . cord-010092-uftc8inx 7002 1 A a DT cord-010092-uftc8inx 7002 2 manual manual JJ cord-010092-uftc8inx 7002 3 double double JJ cord-010092-uftc8inx 7002 4 dose dose NN cord-010092-uftc8inx 7002 5 buffy buffy NNP cord-010092-uftc8inx 7002 6 coat coat NNP cord-010092-uftc8inx 7002 7 production production NN cord-010092-uftc8inx 7002 8 method method NN cord-010092-uftc8inx 7002 9 ( ( -LRB- cord-010092-uftc8inx 7002 10 DD DD NNP cord-010092-uftc8inx 7002 11 - - HYPH cord-010092-uftc8inx 7002 12 BCP BCP NNP cord-010092-uftc8inx 7002 13 ) ) -RRB- cord-010092-uftc8inx 7002 14 in in IN cord-010092-uftc8inx 7002 15 combination combination NN cord-010092-uftc8inx 7002 16 with with IN cord-010092-uftc8inx 7002 17 PR PR NNP cord-010092-uftc8inx 7002 18 enabled enable VBD cord-010092-uftc8inx 7002 19 us -PRON- PRP cord-010092-uftc8inx 7002 20 to to TO cord-010092-uftc8inx 7002 21 reduce reduce VB cord-010092-uftc8inx 7002 22 the the DT cord-010092-uftc8inx 7002 23 BCP BCP NNP cord-010092-uftc8inx 7002 24 - - HYPH cord-010092-uftc8inx 7002 25 disposables disposable NNS cord-010092-uftc8inx 7002 26 cost cost VBN cord-010092-uftc8inx 7002 27 by by IN cord-010092-uftc8inx 7002 28 89.2 89.2 CD cord-010092-uftc8inx 7002 29 % % NN cord-010092-uftc8inx 7002 30 . . . cord-010092-uftc8inx 7003 1 Despite despite IN cord-010092-uftc8inx 7003 2 the the DT cord-010092-uftc8inx 7003 3 moves move NNS cord-010092-uftc8inx 7003 4 from from IN cord-010092-uftc8inx 7003 5 a a DT cord-010092-uftc8inx 7003 6 semi semi RB cord-010092-uftc8inx 7003 7 - - JJ cord-010092-uftc8inx 7003 8 automated automated JJ cord-010092-uftc8inx 7003 9 to to IN cord-010092-uftc8inx 7003 10 a a DT cord-010092-uftc8inx 7003 11 manual manual JJ cord-010092-uftc8inx 7003 12 production production NN cord-010092-uftc8inx 7003 13 method method NN cord-010092-uftc8inx 7003 14 the the DT cord-010092-uftc8inx 7003 15 overall overall JJ cord-010092-uftc8inx 7003 16 scrap scrap NN cord-010092-uftc8inx 7003 17 rates rate NNS cord-010092-uftc8inx 7003 18 during during IN cord-010092-uftc8inx 7003 19 production production NN cord-010092-uftc8inx 7003 20 decreased decrease VBD cord-010092-uftc8inx 7003 21 in in IN cord-010092-uftc8inx 7003 22 2018 2018 CD cord-010092-uftc8inx 7003 23 by by IN cord-010092-uftc8inx 7003 24 0.19 0.19 CD cord-010092-uftc8inx 7003 25 % % NN cord-010092-uftc8inx 7003 26 . . . cord-010092-uftc8inx 7004 1 The the DT cord-010092-uftc8inx 7004 2 extension extension NN cord-010092-uftc8inx 7004 3 of of IN cord-010092-uftc8inx 7004 4 max max NNP cord-010092-uftc8inx 7004 5 . . NNP cord-010092-uftc8inx 7004 6 storage storage NN cord-010092-uftc8inx 7004 7 time time NN cord-010092-uftc8inx 7004 8 from from IN cord-010092-uftc8inx 7004 9 5 5 CD cord-010092-uftc8inx 7004 10 to to TO cord-010092-uftc8inx 7004 11 7 7 CD cord-010092-uftc8inx 7004 12 days day NNS cord-010092-uftc8inx 7004 13 for for IN cord-010092-uftc8inx 7004 14 24 24 CD cord-010092-uftc8inx 7004 15 % % NN cord-010092-uftc8inx 7004 16 of of IN cord-010092-uftc8inx 7004 17 the the DT cord-010092-uftc8inx 7004 18 BCP BCP NNP cord-010092-uftc8inx 7004 19 - - HYPH cord-010092-uftc8inx 7004 20 units unit NNS cord-010092-uftc8inx 7004 21 that that WDT cord-010092-uftc8inx 7004 22 were be VBD cord-010092-uftc8inx 7004 23 PR PR NNP cord-010092-uftc8inx 7004 24 resulted result VBD cord-010092-uftc8inx 7004 25 in in IN cord-010092-uftc8inx 7004 26 decreasing decrease VBG cord-010092-uftc8inx 7004 27 our -PRON- PRP$ cord-010092-uftc8inx 7004 28 overall overall JJ cord-010092-uftc8inx 7004 29 outdating outdate VBG cord-010092-uftc8inx 7004 30 rates rate NNS cord-010092-uftc8inx 7004 31 by by IN cord-010092-uftc8inx 7004 32 29 29 CD cord-010092-uftc8inx 7004 33 % % NN cord-010092-uftc8inx 7004 34 ( ( -LRB- cord-010092-uftc8inx 7004 35 versus versus IN cord-010092-uftc8inx 7004 36 2017 2017 CD cord-010092-uftc8inx 7004 37 ) ) -RRB- cord-010092-uftc8inx 7004 38 . . . cord-010092-uftc8inx 7005 1 This this DT cord-010092-uftc8inx 7005 2 reduction reduction NN cord-010092-uftc8inx 7005 3 in in IN cord-010092-uftc8inx 7005 4 outdating outdate VBG cord-010092-uftc8inx 7005 5 rates rate NNS cord-010092-uftc8inx 7005 6 reduced reduce VBD cord-010092-uftc8inx 7005 7 our -PRON- PRP$ cord-010092-uftc8inx 7005 8 OPC opc NN cord-010092-uftc8inx 7005 9 in in IN cord-010092-uftc8inx 7005 10 2018 2018 CD cord-010092-uftc8inx 7005 11 by by IN cord-010092-uftc8inx 7005 12 2.2 2.2 CD cord-010092-uftc8inx 7005 13 % % NN cord-010092-uftc8inx 7005 14 . . . cord-010092-uftc8inx 7006 1 In in IN cord-010092-uftc8inx 7006 2 2018 2018 CD cord-010092-uftc8inx 7006 3 we -PRON- PRP cord-010092-uftc8inx 7006 4 gamma gamma NN cord-010092-uftc8inx 7006 5 - - HYPH cord-010092-uftc8inx 7006 6 irradiated irradiate VBN cord-010092-uftc8inx 7006 7 25.9 25.9 CD cord-010092-uftc8inx 7006 8 % % NN cord-010092-uftc8inx 7006 9 fewer few JJR cord-010092-uftc8inx 7006 10 BCP BCP NNP cord-010092-uftc8inx 7006 11 - - HYPH cord-010092-uftc8inx 7006 12 units unit NNS cord-010092-uftc8inx 7006 13 , , , cord-010092-uftc8inx 7006 14 but but CC cord-010092-uftc8inx 7006 15 this this DT cord-010092-uftc8inx 7006 16 had have VBD cord-010092-uftc8inx 7006 17 only only RB cord-010092-uftc8inx 7006 18 a a DT cord-010092-uftc8inx 7006 19 minimal minimal JJ cord-010092-uftc8inx 7006 20 impact impact NN cord-010092-uftc8inx 7006 21 on on IN cord-010092-uftc8inx 7006 22 the the DT cord-010092-uftc8inx 7006 23 OPC OPC NNP cord-010092-uftc8inx 7006 24 . . . cord-010092-uftc8inx 7007 1 Summary Summary NNP cord-010092-uftc8inx 7007 2 / / SYM cord-010092-uftc8inx 7007 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 7007 4 : : : cord-010092-uftc8inx 7008 1 Results result NNS cord-010092-uftc8inx 7008 2 of of IN cord-010092-uftc8inx 7008 3 this this DT cord-010092-uftc8inx 7008 4 study study NN cord-010092-uftc8inx 7008 5 confirmed confirm VBD cord-010092-uftc8inx 7008 6 that that IN cord-010092-uftc8inx 7008 7 we -PRON- PRP cord-010092-uftc8inx 7008 8 reached reach VBD cord-010092-uftc8inx 7008 9 our -PRON- PRP$ cord-010092-uftc8inx 7008 10 initial initial JJ cord-010092-uftc8inx 7008 11 objectives objective NNS cord-010092-uftc8inx 7008 12 of of IN cord-010092-uftc8inx 7008 13 producing~25 producing~25 NN cord-010092-uftc8inx 7008 14 % % NN cord-010092-uftc8inx 7008 15 PR pr NN cord-010092-uftc8inx 7008 16 - - HYPH cord-010092-uftc8inx 7008 17 BCP BCP NNP cord-010092-uftc8inx 7008 18 without without IN cord-010092-uftc8inx 7008 19 increasing increase VBG cord-010092-uftc8inx 7008 20 the the DT cord-010092-uftc8inx 7008 21 overall overall JJ cord-010092-uftc8inx 7008 22 production production NN cord-010092-uftc8inx 7008 23 cost cost NN cord-010092-uftc8inx 7008 24 ( ( -LRB- cord-010092-uftc8inx 7008 25 OPC OPC NNP cord-010092-uftc8inx 7008 26 ) ) -RRB- cord-010092-uftc8inx 7008 27 of of IN cord-010092-uftc8inx 7008 28 BCP BCP NNP cord-010092-uftc8inx 7008 29 . . . cord-010092-uftc8inx 7009 1 It -PRON- PRP cord-010092-uftc8inx 7009 2 enabled enable VBD cord-010092-uftc8inx 7009 3 us -PRON- PRP cord-010092-uftc8inx 7009 4 to to TO cord-010092-uftc8inx 7009 5 offer offer VB cord-010092-uftc8inx 7009 6 increased increase VBN cord-010092-uftc8inx 7009 7 blood blood NN cord-010092-uftc8inx 7009 8 safety safety NN cord-010092-uftc8inx 7009 9 to to IN cord-010092-uftc8inx 7009 10 the the DT cord-010092-uftc8inx 7009 11 most most RBS cord-010092-uftc8inx 7009 12 vulnerable vulnerable JJ cord-010092-uftc8inx 7009 13 patients patient NNS cord-010092-uftc8inx 7009 14 . . . cord-010092-uftc8inx 7010 1 We -PRON- PRP cord-010092-uftc8inx 7010 2 built build VBD cord-010092-uftc8inx 7010 3 - - HYPH cord-010092-uftc8inx 7010 4 up up RP cord-010092-uftc8inx 7010 5 enough enough JJ cord-010092-uftc8inx 7010 6 routine routine JJ cord-010092-uftc8inx 7010 7 experience experience NN cord-010092-uftc8inx 7010 8 with with IN cord-010092-uftc8inx 7010 9 PR PR NNP cord-010092-uftc8inx 7010 10 so so IN cord-010092-uftc8inx 7010 11 we -PRON- PRP cord-010092-uftc8inx 7010 12 could could MD cord-010092-uftc8inx 7010 13 quickly quickly RB cord-010092-uftc8inx 7010 14 rampup rampup VB cord-010092-uftc8inx 7010 15 the the DT cord-010092-uftc8inx 7010 16 production production NN cord-010092-uftc8inx 7010 17 of of IN cord-010092-uftc8inx 7010 18 PR PR NNP cord-010092-uftc8inx 7010 19 - - HYPH cord-010092-uftc8inx 7010 20 BCP BCP NNP cord-010092-uftc8inx 7010 21 to to IN cord-010092-uftc8inx 7010 22 100 100 CD cord-010092-uftc8inx 7010 23 % % NN cord-010092-uftc8inx 7010 24 if if IN cord-010092-uftc8inx 7010 25 there there EX cord-010092-uftc8inx 7010 26 were be VBD cord-010092-uftc8inx 7010 27 an an DT cord-010092-uftc8inx 7010 28 outbreak outbreak NN cord-010092-uftc8inx 7010 29 of of IN cord-010092-uftc8inx 7010 30 an an DT cord-010092-uftc8inx 7010 31 emergent emergent JJ cord-010092-uftc8inx 7010 32 pathogen pathogen NN cord-010092-uftc8inx 7010 33 in in IN cord-010092-uftc8inx 7010 34 the the DT cord-010092-uftc8inx 7010 35 Madrid Madrid NNP cord-010092-uftc8inx 7010 36 region region NN cord-010092-uftc8inx 7010 37 . . . cord-010092-uftc8inx 7011 1 Background background NN cord-010092-uftc8inx 7011 2 : : : cord-010092-uftc8inx 7012 1 Irradiation irradiation NN cord-010092-uftc8inx 7012 2 of of IN cord-010092-uftc8inx 7012 3 red red JJ cord-010092-uftc8inx 7012 4 cell cell NN cord-010092-uftc8inx 7012 5 units unit NNS cord-010092-uftc8inx 7012 6 is be VBZ cord-010092-uftc8inx 7012 7 undertaken undertake VBN cord-010092-uftc8inx 7012 8 to to TO cord-010092-uftc8inx 7012 9 prevent prevent VB cord-010092-uftc8inx 7012 10 Transfusion transfusion NN cord-010092-uftc8inx 7012 11 - - HYPH cord-010092-uftc8inx 7012 12 Associated Associated NNP cord-010092-uftc8inx 7012 13 - - HYPH cord-010092-uftc8inx 7012 14 Graft graft NN cord-010092-uftc8inx 7012 15 - - HYPH cord-010092-uftc8inx 7012 16 Versus Versus NNP cord-010092-uftc8inx 7012 17 - - HYPH cord-010092-uftc8inx 7012 18 Host Host NNP cord-010092-uftc8inx 7012 19 - - HYPH cord-010092-uftc8inx 7012 20 Disease Disease NNP cord-010092-uftc8inx 7012 21 ( ( -LRB- cord-010092-uftc8inx 7012 22 TA TA NNP cord-010092-uftc8inx 7012 23 - - HYPH cord-010092-uftc8inx 7012 24 GVHD GVHD NNP cord-010092-uftc8inx 7012 25 ) ) -RRB- cord-010092-uftc8inx 7012 26 in in IN cord-010092-uftc8inx 7012 27 immuno immuno JJ cord-010092-uftc8inx 7012 28 - - HYPH cord-010092-uftc8inx 7012 29 compromised compromise VBN cord-010092-uftc8inx 7012 30 patients patient NNS cord-010092-uftc8inx 7012 31 . . . cord-010092-uftc8inx 7013 1 While while IN cord-010092-uftc8inx 7013 2 irradiators irradiator NNS cord-010092-uftc8inx 7013 3 using use VBG cord-010092-uftc8inx 7013 4 radioactive radioactive JJ cord-010092-uftc8inx 7013 5 c c NN cord-010092-uftc8inx 7013 6 - - HYPH cord-010092-uftc8inx 7013 7 ray ray NN cord-010092-uftc8inx 7013 8 sources source NNS cord-010092-uftc8inx 7013 9 are be VBP cord-010092-uftc8inx 7013 10 primarily primarily RB cord-010092-uftc8inx 7013 11 found find VBN cord-010092-uftc8inx 7013 12 in in IN cord-010092-uftc8inx 7013 13 blood blood NN cord-010092-uftc8inx 7013 14 establishments establishment NNS cord-010092-uftc8inx 7013 15 , , , cord-010092-uftc8inx 7013 16 they -PRON- PRP cord-010092-uftc8inx 7013 17 require require VBP cord-010092-uftc8inx 7013 18 regular regular JJ cord-010092-uftc8inx 7013 19 recalibration recalibration NN cord-010092-uftc8inx 7013 20 and and CC cord-010092-uftc8inx 7013 21 supplementary supplementary JJ cord-010092-uftc8inx 7013 22 safety safety NN cord-010092-uftc8inx 7013 23 measures measure NNS cord-010092-uftc8inx 7013 24 . . . cord-010092-uftc8inx 7014 1 Xirradiation Xirradiation NNP cord-010092-uftc8inx 7014 2 has have VBZ cord-010092-uftc8inx 7014 3 been be VBN cord-010092-uftc8inx 7014 4 shown show VBN cord-010092-uftc8inx 7014 5 to to TO cord-010092-uftc8inx 7014 6 have have VB cord-010092-uftc8inx 7014 7 similar similar JJ cord-010092-uftc8inx 7014 8 biological biological JJ cord-010092-uftc8inx 7014 9 effectiveness effectiveness NN cord-010092-uftc8inx 7014 10 to to IN cord-010092-uftc8inx 7014 11 c c NN cord-010092-uftc8inx 7014 12 - - HYPH cord-010092-uftc8inx 7014 13 irradiation irradiation NN cord-010092-uftc8inx 7014 14 and and CC cord-010092-uftc8inx 7014 15 does do VBZ cord-010092-uftc8inx 7014 16 not not RB cord-010092-uftc8inx 7014 17 require require VB cord-010092-uftc8inx 7014 18 a a DT cord-010092-uftc8inx 7014 19 radioactive radioactive JJ cord-010092-uftc8inx 7014 20 source source NN cord-010092-uftc8inx 7014 21 . . . cord-010092-uftc8inx 7015 1 There there EX cord-010092-uftc8inx 7015 2 is be VBZ cord-010092-uftc8inx 7015 3 international international JJ cord-010092-uftc8inx 7015 4 interest interest NN cord-010092-uftc8inx 7015 5 in in IN cord-010092-uftc8inx 7015 6 moving move VBG cord-010092-uftc8inx 7015 7 away away RB cord-010092-uftc8inx 7015 8 from from IN cord-010092-uftc8inx 7015 9 gamma gamma NN cord-010092-uftc8inx 7015 10 sources source NNS cord-010092-uftc8inx 7015 11 to to TO cord-010092-uftc8inx 7015 12 reduce reduce VB cord-010092-uftc8inx 7015 13 vulnerability vulnerability NN cord-010092-uftc8inx 7015 14 to to IN cord-010092-uftc8inx 7015 15 terrorism terrorism NN cord-010092-uftc8inx 7015 16 . . . cord-010092-uftc8inx 7016 1 Although although IN cord-010092-uftc8inx 7016 2 damaging damaging JJ cord-010092-uftc8inx 7016 3 , , , cord-010092-uftc8inx 7016 4 impacts impact NNS cord-010092-uftc8inx 7016 5 of of IN cord-010092-uftc8inx 7016 6 irradiation irradiation NN cord-010092-uftc8inx 7016 7 on on IN cord-010092-uftc8inx 7016 8 red red JJ cord-010092-uftc8inx 7016 9 cells cell NNS cord-010092-uftc8inx 7016 10 are be VBP cord-010092-uftc8inx 7016 11 well well RB cord-010092-uftc8inx 7016 12 recognised recognise VBN cord-010092-uftc8inx 7016 13 . . . cord-010092-uftc8inx 7017 1 Only only RB cord-010092-uftc8inx 7017 2 a a DT cord-010092-uftc8inx 7017 3 limited limited JJ cord-010092-uftc8inx 7017 4 number number NN cord-010092-uftc8inx 7017 5 of of IN cord-010092-uftc8inx 7017 6 studies study NNS cord-010092-uftc8inx 7017 7 have have VBP cord-010092-uftc8inx 7017 8 compared compare VBN cord-010092-uftc8inx 7017 9 red red JJ cord-010092-uftc8inx 7017 10 cell cell NN cord-010092-uftc8inx 7017 11 component component NN cord-010092-uftc8inx 7017 12 quality quality NN cord-010092-uftc8inx 7017 13 following follow VBG cord-010092-uftc8inx 7017 14 cand cand NNP cord-010092-uftc8inx 7017 15 X x NN cord-010092-uftc8inx 7017 16 - - NN cord-010092-uftc8inx 7017 17 irradiation irradiation NN cord-010092-uftc8inx 7017 18 for for IN cord-010092-uftc8inx 7017 19 both both DT cord-010092-uftc8inx 7017 20 standard standard JJ cord-010092-uftc8inx 7017 21 volume volume NN cord-010092-uftc8inx 7017 22 red red JJ cord-010092-uftc8inx 7017 23 cell cell NN cord-010092-uftc8inx 7017 24 concentrates concentrate VBZ cord-010092-uftc8inx 7017 25 ( ( -LRB- cord-010092-uftc8inx 7017 26 RCC RCC NNP cord-010092-uftc8inx 7017 27 ) ) -RRB- cord-010092-uftc8inx 7017 28 and and CC cord-010092-uftc8inx 7017 29 neonatal neonatal JJ cord-010092-uftc8inx 7017 30 red red JJ cord-010092-uftc8inx 7017 31 cell cell NN cord-010092-uftc8inx 7017 32 splits split NNS cord-010092-uftc8inx 7017 33 ( ( -LRB- cord-010092-uftc8inx 7017 34 RCS RCS NNP cord-010092-uftc8inx 7017 35 ) ) -RRB- cord-010092-uftc8inx 7017 36 . . . cord-010092-uftc8inx 7018 1 Aims aim VBZ cord-010092-uftc8inx 7018 2 : : : cord-010092-uftc8inx 7018 3 To to TO cord-010092-uftc8inx 7018 4 compare compare VB cord-010092-uftc8inx 7018 5 the the DT cord-010092-uftc8inx 7018 6 in in FW cord-010092-uftc8inx 7018 7 vitro vitro FW cord-010092-uftc8inx 7018 8 quality quality NN cord-010092-uftc8inx 7018 9 of of IN cord-010092-uftc8inx 7018 10 RCC RCC NNP cord-010092-uftc8inx 7018 11 and and CC cord-010092-uftc8inx 7018 12 RCS RCS NNP cord-010092-uftc8inx 7018 13 when when WRB cord-010092-uftc8inx 7018 14 subjected subject VBN cord-010092-uftc8inx 7018 15 to to TO cord-010092-uftc8inx 7018 16 cor cor NNP cord-010092-uftc8inx 7018 17 Xirradiation Xirradiation NNP cord-010092-uftc8inx 7018 18 on on IN cord-010092-uftc8inx 7018 19 day day NN cord-010092-uftc8inx 7018 20 14 14 CD cord-010092-uftc8inx 7018 21 of of IN cord-010092-uftc8inx 7018 22 storage storage NN cord-010092-uftc8inx 7018 23 then then RB cord-010092-uftc8inx 7018 24 stored store VBD cord-010092-uftc8inx 7018 25 for for IN cord-010092-uftc8inx 7018 26 a a DT cord-010092-uftc8inx 7018 27 further further JJ cord-010092-uftc8inx 7018 28 14 14 CD cord-010092-uftc8inx 7018 29 days day NNS cord-010092-uftc8inx 7018 30 . . . cord-010092-uftc8inx 7019 1 RCS RCS NNP cord-010092-uftc8inx 7019 2 were be VBD cord-010092-uftc8inx 7019 3 also also RB cord-010092-uftc8inx 7019 4 irradiated irradiate VBN cord-010092-uftc8inx 7019 5 on on IN cord-010092-uftc8inx 7019 6 day day NN cord-010092-uftc8inx 7019 7 5 5 CD cord-010092-uftc8inx 7019 8 of of IN cord-010092-uftc8inx 7019 9 storage storage NN cord-010092-uftc8inx 7019 10 as as IN cord-010092-uftc8inx 7019 11 that that DT cord-010092-uftc8inx 7019 12 is be VBZ cord-010092-uftc8inx 7019 13 most most RBS cord-010092-uftc8inx 7019 14 common common JJ cord-010092-uftc8inx 7019 15 practice practice NN cord-010092-uftc8inx 7019 16 in in IN cord-010092-uftc8inx 7019 17 NHS NHS NNP cord-010092-uftc8inx 7019 18 Blood Blood NNP cord-010092-uftc8inx 7019 19 and and CC cord-010092-uftc8inx 7019 20 Transplant Transplant NNP cord-010092-uftc8inx 7019 21 ( ( -LRB- cord-010092-uftc8inx 7019 22 NHSBT NHSBT NNP cord-010092-uftc8inx 7019 23 ) ) -RRB- cord-010092-uftc8inx 7019 24 . . . cord-010092-uftc8inx 7020 1 Methods method NNS cord-010092-uftc8inx 7020 2 : : : cord-010092-uftc8inx 7021 1 Four four CD cord-010092-uftc8inx 7021 2 RCC RCC NNP cord-010092-uftc8inx 7021 3 were be VBD cord-010092-uftc8inx 7021 4 pooled pool VBN cord-010092-uftc8inx 7021 5 and and CC cord-010092-uftc8inx 7021 6 split split VBD cord-010092-uftc8inx 7021 7 into into IN cord-010092-uftc8inx 7021 8 4 4 CD cord-010092-uftc8inx 7021 9 arms arm NNS cord-010092-uftc8inx 7021 10 on on IN cord-010092-uftc8inx 7021 11 day day NN cord-010092-uftc8inx 7021 12 1 1 CD cord-010092-uftc8inx 7021 13 of of IN cord-010092-uftc8inx 7021 14 storage storage NN cord-010092-uftc8inx 7021 15 , , , cord-010092-uftc8inx 7021 16 with with IN cord-010092-uftc8inx 7021 17 10 10 CD cord-010092-uftc8inx 7021 18 units unit NNS cord-010092-uftc8inx 7021 19 in in IN cord-010092-uftc8inx 7021 20 each each DT cord-010092-uftc8inx 7021 21 arm arm NN cord-010092-uftc8inx 7021 22 . . . cord-010092-uftc8inx 7022 1 All all DT cord-010092-uftc8inx 7022 2 units unit NNS cord-010092-uftc8inx 7022 3 received receive VBD cord-010092-uftc8inx 7022 4 an an DT cord-010092-uftc8inx 7022 5 irradiation irradiation NN cord-010092-uftc8inx 7022 6 dose dose NN cord-010092-uftc8inx 7022 7 of of IN cord-010092-uftc8inx 7022 8 25.9 25.9 CD cord-010092-uftc8inx 7022 9 - - HYPH cord-010092-uftc8inx 7022 10 48.3 48.3 CD cord-010092-uftc8inx 7022 11 Gy Gy NNP cord-010092-uftc8inx 7022 12 . . . cord-010092-uftc8inx 7023 1 Two two CD cord-010092-uftc8inx 7023 2 arms arm NNS cord-010092-uftc8inx 7023 3 remained remain VBD cord-010092-uftc8inx 7023 4 as as IN cord-010092-uftc8inx 7023 5 standard standard JJ cord-010092-uftc8inx 7023 6 volume volume NN cord-010092-uftc8inx 7023 7 RCC RCC NNP cord-010092-uftc8inx 7023 8 and and CC cord-010092-uftc8inx 7023 9 were be VBD cord-010092-uftc8inx 7023 10 either either CC cord-010092-uftc8inx 7023 11 cor cor NNP cord-010092-uftc8inx 7023 12 X X NNP cord-010092-uftc8inx 7023 13 - - HYPH cord-010092-uftc8inx 7023 14 irradiated irradiate VBN cord-010092-uftc8inx 7023 15 on on IN cord-010092-uftc8inx 7023 16 day day NN cord-010092-uftc8inx 7023 17 14 14 CD cord-010092-uftc8inx 7023 18 of of IN cord-010092-uftc8inx 7023 19 storage storage NN cord-010092-uftc8inx 7023 20 . . . cord-010092-uftc8inx 7024 1 The the DT cord-010092-uftc8inx 7024 2 other other JJ cord-010092-uftc8inx 7024 3 two two CD cord-010092-uftc8inx 7024 4 arms arm NNS cord-010092-uftc8inx 7024 5 were be VBD cord-010092-uftc8inx 7024 6 both both DT cord-010092-uftc8inx 7024 7 split split VBN cord-010092-uftc8inx 7024 8 into into IN cord-010092-uftc8inx 7024 9 6 6 CD cord-010092-uftc8inx 7024 10 RCS RCS NNP cord-010092-uftc8inx 7024 11 on on IN cord-010092-uftc8inx 7024 12 day day NN cord-010092-uftc8inx 7024 13 4 4 CD cord-010092-uftc8inx 7024 14 of of IN cord-010092-uftc8inx 7024 15 storage storage NN cord-010092-uftc8inx 7024 16 before before IN cord-010092-uftc8inx 7024 17 being be VBG cord-010092-uftc8inx 7024 18 irradiated irradiate VBN cord-010092-uftc8inx 7024 19 on on IN cord-010092-uftc8inx 7024 20 day day NN cord-010092-uftc8inx 7024 21 5 5 CD cord-010092-uftc8inx 7024 22 ( ( -LRB- cord-010092-uftc8inx 7024 23 early early JJ cord-010092-uftc8inx 7024 24 arm arm NN cord-010092-uftc8inx 7024 25 ) ) -RRB- cord-010092-uftc8inx 7024 26 or or CC cord-010092-uftc8inx 7024 27 day day NN cord-010092-uftc8inx 7024 28 14 14 CD cord-010092-uftc8inx 7024 29 ( ( -LRB- cord-010092-uftc8inx 7024 30 late late JJ cord-010092-uftc8inx 7024 31 arm arm NN cord-010092-uftc8inx 7024 32 ) ) -RRB- cord-010092-uftc8inx 7024 33 of of IN cord-010092-uftc8inx 7024 34 storage storage NN cord-010092-uftc8inx 7024 35 . . . cord-010092-uftc8inx 7025 1 For for IN cord-010092-uftc8inx 7025 2 each each DT cord-010092-uftc8inx 7025 3 replicate replicate VBP cord-010092-uftc8inx 7025 4 in in IN cord-010092-uftc8inx 7025 5 these these DT cord-010092-uftc8inx 7025 6 arms arm NNS cord-010092-uftc8inx 7025 7 , , , cord-010092-uftc8inx 7025 8 3 3 CD cord-010092-uftc8inx 7025 9 splits split NNS cord-010092-uftc8inx 7025 10 were be VBD cord-010092-uftc8inx 7025 11 c c NN cord-010092-uftc8inx 7025 12 - - HYPH cord-010092-uftc8inx 7025 13 irradiated irradiate VBN cord-010092-uftc8inx 7025 14 and and CC cord-010092-uftc8inx 7025 15 3 3 CD cord-010092-uftc8inx 7025 16 splits split VBZ cord-010092-uftc8inx 7025 17 X X NNS cord-010092-uftc8inx 7025 18 - - HYPH cord-010092-uftc8inx 7025 19 irradiated irradiate VBN cord-010092-uftc8inx 7025 20 . . . cord-010092-uftc8inx 7026 1 All all DT cord-010092-uftc8inx 7026 2 arms arm NNS cord-010092-uftc8inx 7026 3 were be VBD cord-010092-uftc8inx 7026 4 tested test VBN cord-010092-uftc8inx 7026 5 a a DT cord-010092-uftc8inx 7026 6 day day NN cord-010092-uftc8inx 7026 7 prior prior RB cord-010092-uftc8inx 7026 8 to to IN cord-010092-uftc8inx 7026 9 irradiation irradiation NN cord-010092-uftc8inx 7026 10 and and CC cord-010092-uftc8inx 7026 11 1 1 CD cord-010092-uftc8inx 7026 12 , , , cord-010092-uftc8inx 7026 13 7 7 CD cord-010092-uftc8inx 7026 14 and and CC cord-010092-uftc8inx 7026 15 14 14 CD cord-010092-uftc8inx 7026 16 days day NNS cord-010092-uftc8inx 7026 17 post post NN cord-010092-uftc8inx 7026 18 - - NN cord-010092-uftc8inx 7026 19 irradiation irradiation NN cord-010092-uftc8inx 7026 20 for for IN cord-010092-uftc8inx 7026 21 red red JJ cord-010092-uftc8inx 7026 22 cell cell NN cord-010092-uftc8inx 7026 23 quality quality NN cord-010092-uftc8inx 7026 24 parameters parameter NNS cord-010092-uftc8inx 7026 25 : : : cord-010092-uftc8inx 7026 26 haemolysis haemolysis NN cord-010092-uftc8inx 7026 27 , , , cord-010092-uftc8inx 7026 28 intracellular intracellular JJ cord-010092-uftc8inx 7026 29 ATP ATP NNP cord-010092-uftc8inx 7026 30 and and CC cord-010092-uftc8inx 7026 31 2,3 2,3 CD cord-010092-uftc8inx 7026 32 DPG DPG NNP cord-010092-uftc8inx 7026 33 , , , cord-010092-uftc8inx 7026 34 supernatant supernatant JJ cord-010092-uftc8inx 7026 35 potassium potassium NN cord-010092-uftc8inx 7026 36 , , , cord-010092-uftc8inx 7026 37 glucose glucose NN cord-010092-uftc8inx 7026 38 and and CC cord-010092-uftc8inx 7026 39 lactate lactate NN cord-010092-uftc8inx 7026 40 , , , cord-010092-uftc8inx 7026 41 pH ph NN cord-010092-uftc8inx 7026 42 and and CC cord-010092-uftc8inx 7026 43 red red JJ cord-010092-uftc8inx 7026 44 cell cell NN cord-010092-uftc8inx 7026 45 microvesicle microvesicle NNP cord-010092-uftc8inx 7026 46 release release NN cord-010092-uftc8inx 7026 47 . . . cord-010092-uftc8inx 7027 1 The the DT cord-010092-uftc8inx 7027 2 RCC RCC NNP cord-010092-uftc8inx 7027 3 arms arm NNS cord-010092-uftc8inx 7027 4 were be VBD cord-010092-uftc8inx 7027 5 sampled sample VBN cord-010092-uftc8inx 7027 6 over over IN cord-010092-uftc8inx 7027 7 storage storage NN cord-010092-uftc8inx 7027 8 ; ; : cord-010092-uftc8inx 7027 9 while while IN cord-010092-uftc8inx 7027 10 for for IN cord-010092-uftc8inx 7027 11 the the DT cord-010092-uftc8inx 7027 12 RCS RCS NNP cord-010092-uftc8inx 7027 13 arms arm NNS cord-010092-uftc8inx 7027 14 , , , cord-010092-uftc8inx 7027 15 1 1 CD cord-010092-uftc8inx 7027 16 split split NN cord-010092-uftc8inx 7027 17 was be VBD cord-010092-uftc8inx 7027 18 tested test VBN cord-010092-uftc8inx 7027 19 on on IN cord-010092-uftc8inx 7027 20 each each DT cord-010092-uftc8inx 7027 21 testing testing NN cord-010092-uftc8inx 7027 22 day day NN cord-010092-uftc8inx 7027 23 post post NN cord-010092-uftc8inx 7027 24 - - NN cord-010092-uftc8inx 7027 25 irradiation irradiation NN cord-010092-uftc8inx 7027 26 . . . cord-010092-uftc8inx 7028 1 A a DT cord-010092-uftc8inx 7028 2 2-way 2-way JJ cord-010092-uftc8inx 7028 3 ANOVA ANOVA NNP cord-010092-uftc8inx 7028 4 was be VBD cord-010092-uftc8inx 7028 5 used use VBN cord-010092-uftc8inx 7028 6 to to TO cord-010092-uftc8inx 7028 7 detect detect VB cord-010092-uftc8inx 7028 8 statistical statistical JJ cord-010092-uftc8inx 7028 9 differences difference NNS cord-010092-uftc8inx 7028 10 over over IN cord-010092-uftc8inx 7028 11 storage storage NN cord-010092-uftc8inx 7028 12 between between IN cord-010092-uftc8inx 7028 13 cand cand NNP cord-010092-uftc8inx 7028 14 X x NN cord-010092-uftc8inx 7028 15 - - NN cord-010092-uftc8inx 7028 16 irradiation irradiation NN cord-010092-uftc8inx 7028 17 for for IN cord-010092-uftc8inx 7028 18 the the DT cord-010092-uftc8inx 7028 19 same same JJ cord-010092-uftc8inx 7028 20 components component NNS cord-010092-uftc8inx 7028 21 . . . cord-010092-uftc8inx 7029 1 Results result NNS cord-010092-uftc8inx 7029 2 : : : cord-010092-uftc8inx 7030 1 All all DT cord-010092-uftc8inx 7030 2 components component NNS cord-010092-uftc8inx 7030 3 produced produce VBN cord-010092-uftc8inx 7030 4 were be VBD cord-010092-uftc8inx 7030 5 within within IN cord-010092-uftc8inx 7030 6 NHSBT nhsbt JJ cord-010092-uftc8inx 7030 7 specification specification NN cord-010092-uftc8inx 7030 8 for for IN cord-010092-uftc8inx 7030 9 volume volume NN cord-010092-uftc8inx 7030 10 , , , cord-010092-uftc8inx 7030 11 haemoglobin haemoglobin NN cord-010092-uftc8inx 7030 12 and and CC cord-010092-uftc8inx 7030 13 haematocrit haematocrit NNP cord-010092-uftc8inx 7030 14 . . . cord-010092-uftc8inx 7031 1 There there EX cord-010092-uftc8inx 7031 2 were be VBD cord-010092-uftc8inx 7031 3 no no DT cord-010092-uftc8inx 7031 4 significant significant JJ cord-010092-uftc8inx 7031 5 differences difference NNS cord-010092-uftc8inx 7031 6 in in IN cord-010092-uftc8inx 7031 7 red red JJ cord-010092-uftc8inx 7031 8 cell cell NN cord-010092-uftc8inx 7031 9 in in IN cord-010092-uftc8inx 7031 10 vitro vitro FW cord-010092-uftc8inx 7031 11 quality quality NN cord-010092-uftc8inx 7031 12 parameters parameter NNS cord-010092-uftc8inx 7031 13 studied study VBN cord-010092-uftc8inx 7031 14 over over IN cord-010092-uftc8inx 7031 15 storage storage NN cord-010092-uftc8inx 7031 16 between between IN cord-010092-uftc8inx 7031 17 cand cand NNP cord-010092-uftc8inx 7031 18 X X NNP cord-010092-uftc8inx 7031 19 - - HYPH cord-010092-uftc8inx 7031 20 irradiated irradiate VBN cord-010092-uftc8inx 7031 21 units unit NNS cord-010092-uftc8inx 7031 22 , , , cord-010092-uftc8inx 7031 23 for for IN cord-010092-uftc8inx 7031 24 standard standard JJ cord-010092-uftc8inx 7031 25 volume volume NN cord-010092-uftc8inx 7031 26 arms arm NNS cord-010092-uftc8inx 7031 27 or or CC cord-010092-uftc8inx 7031 28 neonatal neonatal JJ cord-010092-uftc8inx 7031 29 arms arm NNS cord-010092-uftc8inx 7031 30 and and CC cord-010092-uftc8inx 7031 31 whether whether IN cord-010092-uftc8inx 7031 32 RCS RCS NNP cord-010092-uftc8inx 7031 33 were be VBD cord-010092-uftc8inx 7031 34 irradiated irradiate VBN cord-010092-uftc8inx 7031 35 early early JJ cord-010092-uftc8inx 7031 36 or or CC cord-010092-uftc8inx 7031 37 late late JJ cord-010092-uftc8inx 7031 38 in in IN cord-010092-uftc8inx 7031 39 storage storage NN cord-010092-uftc8inx 7031 40 . . . cord-010092-uftc8inx 7032 1 Moreover moreover RB cord-010092-uftc8inx 7032 2 , , , cord-010092-uftc8inx 7032 3 all all DT cord-010092-uftc8inx 7032 4 arms arm NNS cord-010092-uftc8inx 7032 5 were be VBD cord-010092-uftc8inx 7032 6 within within IN cord-010092-uftc8inx 7032 7 haemolysis haemolysis NN cord-010092-uftc8inx 7032 8 specification specification NN cord-010092-uftc8inx 7032 9 for for IN cord-010092-uftc8inx 7032 10 the the DT cord-010092-uftc8inx 7032 11 end end NN cord-010092-uftc8inx 7032 12 of of IN cord-010092-uftc8inx 7032 13 storage storage NN cord-010092-uftc8inx 7032 14 ( ( -LRB- cord-010092-uftc8inx 7032 15 > > XX cord-010092-uftc8inx 7033 1 75 75 CD cord-010092-uftc8inx 7033 2 % % NN cord-010092-uftc8inx 7033 3 of of IN cord-010092-uftc8inx 7033 4 units unit NNS cord-010092-uftc8inx 7033 5 with with IN cord-010092-uftc8inx 7033 6 < < XX cord-010092-uftc8inx 7033 7 0.8 0.8 CD cord-010092-uftc8inx 7033 8 % % NN cord-010092-uftc8inx 7033 9 haemolysis haemolysis NNP cord-010092-uftc8inx 7033 10 ) ) -RRB- cord-010092-uftc8inx 7033 11 and and CC cord-010092-uftc8inx 7033 12 100 100 CD cord-010092-uftc8inx 7033 13 % % NN cord-010092-uftc8inx 7033 14 of of IN cord-010092-uftc8inx 7033 15 units unit NNS cord-010092-uftc8inx 7033 16 had have VBD cord-010092-uftc8inx 7033 17 ATP ATP NNP cord-010092-uftc8inx 7033 18 levels level NNS cord-010092-uftc8inx 7033 19 above above IN cord-010092-uftc8inx 7033 20 the the DT cord-010092-uftc8inx 7033 21 recommended recommend VBN cord-010092-uftc8inx 7033 22 minimum minimum NN cord-010092-uftc8inx 7033 23 for for IN cord-010092-uftc8inx 7033 24 acceptable acceptable JJ cord-010092-uftc8inx 7033 25 post post JJ cord-010092-uftc8inx 7033 26 - - JJ cord-010092-uftc8inx 7033 27 transfusion transfusion JJ cord-010092-uftc8inx 7033 28 survival survival NN cord-010092-uftc8inx 7033 29 ( ( -LRB- cord-010092-uftc8inx 7033 30 2.3 2.3 CD cord-010092-uftc8inx 7033 31 lmol lmol JJ cord-010092-uftc8inx 7033 32 / / SYM cord-010092-uftc8inx 7033 33 gHb gHb NNP cord-010092-uftc8inx 7033 34 ) ) -RRB- cord-010092-uftc8inx 7033 35 . . . cord-010092-uftc8inx 7034 1 Both both DT cord-010092-uftc8inx 7034 2 haemolysis haemolysis NN cord-010092-uftc8inx 7034 3 and and CC cord-010092-uftc8inx 7034 4 potassium potassium NN cord-010092-uftc8inx 7034 5 levels level NNS cord-010092-uftc8inx 7034 6 at at IN cord-010092-uftc8inx 7034 7 the the DT cord-010092-uftc8inx 7034 8 end end NN cord-010092-uftc8inx 7034 9 of of IN cord-010092-uftc8inx 7034 10 storage storage NN cord-010092-uftc8inx 7034 11 for for IN cord-010092-uftc8inx 7034 12 the the DT cord-010092-uftc8inx 7034 13 standard standard JJ cord-010092-uftc8inx 7034 14 c c NNP cord-010092-uftc8inx 7034 15 - - HYPH cord-010092-uftc8inx 7034 16 irradiated irradiate VBN cord-010092-uftc8inx 7034 17 RCC RCC NNP cord-010092-uftc8inx 7034 18 were be VBD cord-010092-uftc8inx 7034 19 comparable comparable JJ cord-010092-uftc8inx 7034 20 to to IN cord-010092-uftc8inx 7034 21 our -PRON- PRP$ cord-010092-uftc8inx 7034 22 laboratory laboratory NN cord-010092-uftc8inx 7034 23 's 's POS cord-010092-uftc8inx 7034 24 historic historic JJ cord-010092-uftc8inx 7034 25 data datum NNS cord-010092-uftc8inx 7034 26 for for IN cord-010092-uftc8inx 7034 27 the the DT cord-010092-uftc8inx 7034 28 same same JJ cord-010092-uftc8inx 7034 29 component component NN cord-010092-uftc8inx 7034 30 . . . cord-010092-uftc8inx 7035 1 Summary Summary NNP cord-010092-uftc8inx 7035 2 / / SYM cord-010092-uftc8inx 7035 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 7035 4 : : : cord-010092-uftc8inx 7036 1 In in IN cord-010092-uftc8inx 7036 2 summary summary NN cord-010092-uftc8inx 7036 3 , , , cord-010092-uftc8inx 7036 4 the the DT cord-010092-uftc8inx 7036 5 storage storage NN cord-010092-uftc8inx 7036 6 quality quality NN cord-010092-uftc8inx 7036 7 of of IN cord-010092-uftc8inx 7036 8 RCC RCC NNP cord-010092-uftc8inx 7036 9 and and CC cord-010092-uftc8inx 7036 10 RCS RCS NNP cord-010092-uftc8inx 7036 11 post post NNP cord-010092-uftc8inx 7036 12 - - NNP cord-010092-uftc8inx 7036 13 Xirradiation Xirradiation NNP cord-010092-uftc8inx 7036 14 did do VBD cord-010092-uftc8inx 7036 15 not not RB cord-010092-uftc8inx 7036 16 differ differ VB cord-010092-uftc8inx 7036 17 from from IN cord-010092-uftc8inx 7036 18 c c NN cord-010092-uftc8inx 7036 19 - - HYPH cord-010092-uftc8inx 7036 20 irradiation irradiation NN cord-010092-uftc8inx 7036 21 in in IN cord-010092-uftc8inx 7036 22 this this DT cord-010092-uftc8inx 7036 23 study study NN cord-010092-uftc8inx 7036 24 , , , cord-010092-uftc8inx 7036 25 providing provide VBG cord-010092-uftc8inx 7036 26 reassurance reassurance NN cord-010092-uftc8inx 7036 27 that that IN cord-010092-uftc8inx 7036 28 either either DT cord-010092-uftc8inx 7036 29 method method NN cord-010092-uftc8inx 7036 30 could could MD cord-010092-uftc8inx 7036 31 be be VB cord-010092-uftc8inx 7036 32 used use VBN cord-010092-uftc8inx 7036 33 in in IN cord-010092-uftc8inx 7036 34 routine routine JJ cord-010092-uftc8inx 7036 35 manufacturing manufacturing NN cord-010092-uftc8inx 7036 36 . . . cord-010092-uftc8inx 7037 1 A a DT cord-010092-uftc8inx 7037 2 Pajares Pajares NNP cord-010092-uftc8inx 7037 3 Herraiz Herraiz NNP cord-010092-uftc8inx 7037 4 1 1 CD cord-010092-uftc8inx 7037 5 , , , cord-010092-uftc8inx 7037 6 C C NNP cord-010092-uftc8inx 7037 7 Coello Coello NNP cord-010092-uftc8inx 7037 8 de de NNP cord-010092-uftc8inx 7037 9 Portugal Portugal NNP cord-010092-uftc8inx 7037 10 2 2 CD cord-010092-uftc8inx 7037 11 , , , cord-010092-uftc8inx 7037 12 M M NNP cord-010092-uftc8inx 7037 13 Morales Morales NNP cord-010092-uftc8inx 7037 14 3 3 CD cord-010092-uftc8inx 7037 15 , , , cord-010092-uftc8inx 7037 16 F F NNP cord-010092-uftc8inx 7037 17 Solano Solano NNP cord-010092-uftc8inx 7037 18 4 4 CD cord-010092-uftc8inx 7037 19 , , , cord-010092-uftc8inx 7037 20 C C NNP cord-010092-uftc8inx 7037 21 Perez Perez NNP cord-010092-uftc8inx 7037 22 Parrillas Parrillas NNP cord-010092-uftc8inx 7037 23 5 5 CD cord-010092-uftc8inx 7037 24 , , , cord-010092-uftc8inx 7037 25 A a DT cord-010092-uftc8inx 7037 26 Rodriguez Rodriguez NNP cord-010092-uftc8inx 7037 27 Hidalgo Hidalgo NNP cord-010092-uftc8inx 7037 28 5 5 CD cord-010092-uftc8inx 7037 29 , , , cord-010092-uftc8inx 7037 30 T T NNP cord-010092-uftc8inx 7037 31 Diaz Diaz NNP cord-010092-uftc8inx 7037 32 Rueda Rueda NNP cord-010092-uftc8inx 7037 33 5 5 CD cord-010092-uftc8inx 7037 34 and and CC cord-010092-uftc8inx 7037 35 M M NNP cord-010092-uftc8inx 7037 36 Flores Flores NNP cord-010092-uftc8inx 7038 1 5 5 CD cord-010092-uftc8inx 7038 2 1 1 CD cord-010092-uftc8inx 7038 3 Direccion Direccion NNP cord-010092-uftc8inx 7038 4 , , , cord-010092-uftc8inx 7038 5 Regional Regional NNP cord-010092-uftc8inx 7038 6 Transfusion Transfusion NNP cord-010092-uftc8inx 7038 7 Center Center NNP cord-010092-uftc8inx 7038 8 Toledo Toledo NNP cord-010092-uftc8inx 7038 9 - - HYPH cord-010092-uftc8inx 7038 10 Guadalajara Guadalajara NNP cord-010092-uftc8inx 7038 11 2 2 CD cord-010092-uftc8inx 7038 12 Transfusion Transfusion NNP cord-010092-uftc8inx 7038 13 Service Service NNP cord-010092-uftc8inx 7038 14 , , , cord-010092-uftc8inx 7038 15 Toledo Toledo NNP cord-010092-uftc8inx 7038 16 Hospital Hospital NNP cord-010092-uftc8inx 7038 17 Complex Complex NNP cord-010092-uftc8inx 7038 18 , , , cord-010092-uftc8inx 7038 19 Toledo Toledo NNP cord-010092-uftc8inx 7038 20 3 3 CD cord-010092-uftc8inx 7038 21 Transfusion Transfusion NNP cord-010092-uftc8inx 7038 22 Service Service NNP cord-010092-uftc8inx 7038 23 , , , cord-010092-uftc8inx 7038 24 General General NNP cord-010092-uftc8inx 7038 25 University University NNP cord-010092-uftc8inx 7038 26 Hospital Hospital NNP cord-010092-uftc8inx 7038 27 of of IN cord-010092-uftc8inx 7038 28 Guadalajara Guadalajara NNP cord-010092-uftc8inx 7038 29 , , , cord-010092-uftc8inx 7038 30 Guadalajara Guadalajara NNP cord-010092-uftc8inx 7038 31 4 4 CD cord-010092-uftc8inx 7038 32 Transfusion Transfusion NNP cord-010092-uftc8inx 7038 33 Service Service NNP cord-010092-uftc8inx 7038 34 , , , cord-010092-uftc8inx 7038 35 Hospital Hospital NNP cord-010092-uftc8inx 7038 36 Nuestra Nuestra NNP cord-010092-uftc8inx 7038 37 Señora Señora NNP cord-010092-uftc8inx 7038 38 del del NNP cord-010092-uftc8inx 7038 39 Prado Prado NNP cord-010092-uftc8inx 7038 40 de de IN cord-010092-uftc8inx 7038 41 Talavera Talavera NNP cord-010092-uftc8inx 7038 42 de de NNP cord-010092-uftc8inx 7038 43 la la NNP cord-010092-uftc8inx 7038 44 Reina Reina NNP cord-010092-uftc8inx 7038 45 , , , cord-010092-uftc8inx 7038 46 Talavera Talavera NNP cord-010092-uftc8inx 7038 47 5 5 CD cord-010092-uftc8inx 7038 48 Regional Regional NNP cord-010092-uftc8inx 7038 49 Transfusion Transfusion NNP cord-010092-uftc8inx 7038 50 Center Center NNP cord-010092-uftc8inx 7038 51 , , , cord-010092-uftc8inx 7038 52 Regional Regional NNP cord-010092-uftc8inx 7038 53 Transfusion Transfusion NNP cord-010092-uftc8inx 7038 54 Center Center NNP cord-010092-uftc8inx 7038 55 Toledo Toledo NNP cord-010092-uftc8inx 7038 56 - - HYPH cord-010092-uftc8inx 7038 57 Guadalajara Guadalajara NNP cord-010092-uftc8inx 7038 58 , , , cord-010092-uftc8inx 7038 59 Toledo Toledo NNP cord-010092-uftc8inx 7039 1 , , , cord-010092-uftc8inx 7039 2 Spain Spain NNP cord-010092-uftc8inx 7039 3 Background Background NNP cord-010092-uftc8inx 7039 4 : : : cord-010092-uftc8inx 7040 1 The the DT cord-010092-uftc8inx 7040 2 Regional Regional NNP cord-010092-uftc8inx 7040 3 Transfusion Transfusion NNP cord-010092-uftc8inx 7040 4 Center Center NNP cord-010092-uftc8inx 7040 5 of of IN cord-010092-uftc8inx 7040 6 Toledo Toledo NNP cord-010092-uftc8inx 7040 7 - - HYPH cord-010092-uftc8inx 7040 8 Guadalajara Guadalajara NNP cord-010092-uftc8inx 7040 9 ( ( -LRB- cord-010092-uftc8inx 7040 10 RTC RTC NNP cord-010092-uftc8inx 7040 11 ) ) -RRB- cord-010092-uftc8inx 7040 12 manages manage VBZ cord-010092-uftc8inx 7040 13 the the DT cord-010092-uftc8inx 7040 14 collection collection NN cord-010092-uftc8inx 7040 15 , , , cord-010092-uftc8inx 7040 16 processing processing NN cord-010092-uftc8inx 7040 17 and and CC cord-010092-uftc8inx 7040 18 distribution distribution NN cord-010092-uftc8inx 7040 19 of of IN cord-010092-uftc8inx 7040 20 blood blood NN cord-010092-uftc8inx 7040 21 components component NNS cord-010092-uftc8inx 7040 22 for for IN cord-010092-uftc8inx 7040 23 the the DT cord-010092-uftc8inx 7040 24 hemotherapy hemotherapy NNP cord-010092-uftc8inx 7040 25 area area NN cord-010092-uftc8inx 7040 26 of of IN cord-010092-uftc8inx 7040 27 Castilla Castilla NNP cord-010092-uftc8inx 7040 28 La La NNP cord-010092-uftc8inx 7040 29 Mancha Mancha NNP cord-010092-uftc8inx 7040 30 ( ( -LRB- cord-010092-uftc8inx 7040 31 Spain Spain NNP cord-010092-uftc8inx 7040 32 ) ) -RRB- cord-010092-uftc8inx 7040 33 that that WDT cord-010092-uftc8inx 7040 34 serves serve VBZ cord-010092-uftc8inx 7040 35 3 3 CD cord-010092-uftc8inx 7040 36 general general JJ cord-010092-uftc8inx 7040 37 hospitals hospital NNS cord-010092-uftc8inx 7040 38 ( ( -LRB- cord-010092-uftc8inx 7040 39 Hospital Hospital NNP cord-010092-uftc8inx 7040 40 Complex Complex NNP cord-010092-uftc8inx 7040 41 of of IN cord-010092-uftc8inx 7040 42 Toledo Toledo NNP cord-010092-uftc8inx 7040 43 ( ( -LRB- cord-010092-uftc8inx 7040 44 HCT HCT NNP cord-010092-uftc8inx 7040 45 ) ) -RRB- cord-010092-uftc8inx 7040 46 , , , cord-010092-uftc8inx 7040 47 University University NNP cord-010092-uftc8inx 7040 48 General General NNP cord-010092-uftc8inx 7040 49 Hospital Hospital NNP cord-010092-uftc8inx 7040 50 of of IN cord-010092-uftc8inx 7040 51 Guadalajara Guadalajara NNP cord-010092-uftc8inx 7040 52 ( ( -LRB- cord-010092-uftc8inx 7040 53 UGHG UGHG NNP cord-010092-uftc8inx 7040 54 ) ) -RRB- cord-010092-uftc8inx 7040 55 and and CC cord-010092-uftc8inx 7040 56 Hospital Hospital NNP cord-010092-uftc8inx 7040 57 Nuestra Nuestra NNP cord-010092-uftc8inx 7040 58 Señora Señora NNP cord-010092-uftc8inx 7040 59 del del NNP cord-010092-uftc8inx 7040 60 Prado Prado NNP cord-010092-uftc8inx 7040 61 de de IN cord-010092-uftc8inx 7040 62 Talavera Talavera NNP cord-010092-uftc8inx 7040 63 ( ( -LRB- cord-010092-uftc8inx 7040 64 NSPT NSPT NNP cord-010092-uftc8inx 7040 65 ) ) -RRB- cord-010092-uftc8inx 7040 66 ) ) -RRB- cord-010092-uftc8inx 7041 1 and and CC cord-010092-uftc8inx 7041 2 the the DT cord-010092-uftc8inx 7041 3 needs need NNS cord-010092-uftc8inx 7041 4 of of IN cord-010092-uftc8inx 7041 5 943,000 943,000 CD cord-010092-uftc8inx 7041 6 inhabitants inhabitant NNS cord-010092-uftc8inx 7041 7 . . . cord-010092-uftc8inx 7042 1 By by IN cord-010092-uftc8inx 7042 2 also also RB cord-010092-uftc8inx 7042 3 managing manage VBG cord-010092-uftc8inx 7042 4 the the DT cord-010092-uftc8inx 7042 5 HCT HCT NNP cord-010092-uftc8inx 7042 6 Transfusion Transfusion NNP cord-010092-uftc8inx 7042 7 Service Service NNP cord-010092-uftc8inx 7042 8 , , , cord-010092-uftc8inx 7042 9 it -PRON- PRP cord-010092-uftc8inx 7042 10 facilitates facilitate VBZ cord-010092-uftc8inx 7042 11 the the DT cord-010092-uftc8inx 7042 12 handling handling NN cord-010092-uftc8inx 7042 13 of of IN cord-010092-uftc8inx 7042 14 stocks stock NNS cord-010092-uftc8inx 7042 15 . . . cord-010092-uftc8inx 7043 1 Since since IN cord-010092-uftc8inx 7043 2 2008 2008 CD cord-010092-uftc8inx 7043 3 , , , cord-010092-uftc8inx 7043 4 RTC RTC NNP cord-010092-uftc8inx 7043 5 has have VBZ cord-010092-uftc8inx 7043 6 initiated initiate VBN cord-010092-uftc8inx 7043 7 pathogen pathogen NN cord-010092-uftc8inx 7043 8 inactivation inactivation NN cord-010092-uftc8inx 7043 9 ( ( -LRB- cord-010092-uftc8inx 7043 10 PI PI NNP cord-010092-uftc8inx 7043 11 ) ) -RRB- cord-010092-uftc8inx 7043 12 for for IN cord-010092-uftc8inx 7043 13 a a DT cord-010092-uftc8inx 7043 14 part part NN cord-010092-uftc8inx 7043 15 of of IN cord-010092-uftc8inx 7043 16 its -PRON- PRP$ cord-010092-uftc8inx 7043 17 platelet platelet NN cord-010092-uftc8inx 7043 18 components(PC components(pc RB cord-010092-uftc8inx 7043 19 ) ) -RRB- cord-010092-uftc8inx 7043 20 with with IN cord-010092-uftc8inx 7043 21 the the DT cord-010092-uftc8inx 7043 22 INTERCEPT INTERCEPT NNP cord-010092-uftc8inx 7043 23 Blood blood NN cord-010092-uftc8inx 7043 24 system system NN cord-010092-uftc8inx 7043 25 ( ( -LRB- cord-010092-uftc8inx 7043 26 Cerus Cerus NNP cord-010092-uftc8inx 7043 27 ) ) -RRB- cord-010092-uftc8inx 7043 28 using use VBG cord-010092-uftc8inx 7043 29 a a DT cord-010092-uftc8inx 7043 30 photochemical photochemical JJ cord-010092-uftc8inx 7043 31 treatment treatment NN cord-010092-uftc8inx 7043 32 with with IN cord-010092-uftc8inx 7043 33 amotosalen amotosalen NN cord-010092-uftc8inx 7043 34 and and CC cord-010092-uftc8inx 7043 35 ultraviolet ultraviolet NN cord-010092-uftc8inx 7043 36 - - HYPH cord-010092-uftc8inx 7043 37 A. a. NN cord-010092-uftc8inx 7044 1 This this DT cord-010092-uftc8inx 7044 2 system system NN cord-010092-uftc8inx 7044 3 allows allow VBZ cord-010092-uftc8inx 7044 4 the the DT cord-010092-uftc8inx 7044 5 inactivation inactivation NN cord-010092-uftc8inx 7044 6 of of IN cord-010092-uftc8inx 7044 7 a a DT cord-010092-uftc8inx 7044 8 broad broad JJ cord-010092-uftc8inx 7044 9 panel panel NN cord-010092-uftc8inx 7044 10 of of IN cord-010092-uftc8inx 7044 11 pathogens pathogen NNS cord-010092-uftc8inx 7044 12 and and CC cord-010092-uftc8inx 7044 13 leukocytes leukocyte NNS cord-010092-uftc8inx 7044 14 , , , cord-010092-uftc8inx 7044 15 extending extend VBG cord-010092-uftc8inx 7044 16 the the DT cord-010092-uftc8inx 7044 17 shelf shelf NN cord-010092-uftc8inx 7044 18 - - HYPH cord-010092-uftc8inx 7044 19 life life NN cord-010092-uftc8inx 7044 20 of of IN cord-010092-uftc8inx 7044 21 the the DT cord-010092-uftc8inx 7044 22 CP CP NNP cord-010092-uftc8inx 7044 23 from from IN cord-010092-uftc8inx 7044 24 5 5 CD cord-010092-uftc8inx 7044 25 to to TO cord-010092-uftc8inx 7044 26 7 7 CD cord-010092-uftc8inx 7044 27 days day NNS cord-010092-uftc8inx 7044 28 . . . cord-010092-uftc8inx 7045 1 This this DT cord-010092-uftc8inx 7045 2 affects affect VBZ cord-010092-uftc8inx 7045 3 the the DT cord-010092-uftc8inx 7045 4 expiry expiry NN cord-010092-uftc8inx 7045 5 and and CC cord-010092-uftc8inx 7045 6 discards discard NNS cord-010092-uftc8inx 7045 7 of of IN cord-010092-uftc8inx 7045 8 this this DT cord-010092-uftc8inx 7045 9 blood blood NN cord-010092-uftc8inx 7045 10 component component NN cord-010092-uftc8inx 7045 11 , , , cord-010092-uftc8inx 7045 12 allows allow VBZ cord-010092-uftc8inx 7045 13 a a DT cord-010092-uftc8inx 7045 14 better well JJR cord-010092-uftc8inx 7045 15 management management NN cord-010092-uftc8inx 7045 16 of of IN cord-010092-uftc8inx 7045 17 the the DT cord-010092-uftc8inx 7045 18 inventory inventory NN cord-010092-uftc8inx 7045 19 and and CC cord-010092-uftc8inx 7045 20 has have VBZ cord-010092-uftc8inx 7045 21 an an DT cord-010092-uftc8inx 7045 22 influence influence NN cord-010092-uftc8inx 7045 23 on on IN cord-010092-uftc8inx 7045 24 production production NN cord-010092-uftc8inx 7045 25 costs cost NNS cord-010092-uftc8inx 7045 26 . . . cord-010092-uftc8inx 7046 1 Aims aim VBZ cord-010092-uftc8inx 7046 2 : : : cord-010092-uftc8inx 7046 3 The the DT cord-010092-uftc8inx 7046 4 objective objective NN cord-010092-uftc8inx 7046 5 was be VBD cord-010092-uftc8inx 7046 6 to to TO cord-010092-uftc8inx 7046 7 evaluate evaluate VB cord-010092-uftc8inx 7046 8 the the DT cord-010092-uftc8inx 7046 9 influence influence NN cord-010092-uftc8inx 7046 10 of of IN cord-010092-uftc8inx 7046 11 PI pi NN cord-010092-uftc8inx 7046 12 in in IN cord-010092-uftc8inx 7046 13 the the DT cord-010092-uftc8inx 7046 14 production production NN cord-010092-uftc8inx 7046 15 of of IN cord-010092-uftc8inx 7046 16 CP cp NN cord-010092-uftc8inx 7046 17 at at IN cord-010092-uftc8inx 7046 18 RTC RTC NNP cord-010092-uftc8inx 7046 19 and and CC cord-010092-uftc8inx 7046 20 the the DT cord-010092-uftc8inx 7046 21 expiry expiry NN cord-010092-uftc8inx 7046 22 in in IN cord-010092-uftc8inx 7046 23 the the DT cord-010092-uftc8inx 7046 24 hemotherapy hemotherapy NNP cord-010092-uftc8inx 7046 25 area area NN cord-010092-uftc8inx 7046 26 during during IN cord-010092-uftc8inx 7046 27 the the DT cord-010092-uftc8inx 7046 28 last last JJ cord-010092-uftc8inx 7046 29 8 8 CD cord-010092-uftc8inx 7046 30 years year NNS cord-010092-uftc8inx 7046 31 divided divide VBN cord-010092-uftc8inx 7046 32 into into IN cord-010092-uftc8inx 7046 33 four four CD cord-010092-uftc8inx 7046 34 periods period NNS cord-010092-uftc8inx 7046 35 ( ( -LRB- cord-010092-uftc8inx 7046 36 Results result NNS cord-010092-uftc8inx 7046 37 : : : cord-010092-uftc8inx 7047 1 PC pc NN cord-010092-uftc8inx 7047 2 were be VBD cord-010092-uftc8inx 7047 3 predominantly predominantly RB cord-010092-uftc8inx 7047 4 obtained obtain VBN cord-010092-uftc8inx 7047 5 from from IN cord-010092-uftc8inx 7047 6 whole whole JJ cord-010092-uftc8inx 7047 7 blood blood NN cord-010092-uftc8inx 7047 8 collections collection NNS cord-010092-uftc8inx 7047 9 with with IN cord-010092-uftc8inx 7047 10 85 85 CD cord-010092-uftc8inx 7047 11 % % NN cord-010092-uftc8inx 7047 12 of of IN cord-010092-uftc8inx 7047 13 BC BC NNP cord-010092-uftc8inx 7047 14 platelets/15 platelets/15 NNP cord-010092-uftc8inx 7047 15 % % NN cord-010092-uftc8inx 7047 16 of of IN cord-010092-uftc8inx 7047 17 apheresis apheresis NN cord-010092-uftc8inx 7047 18 platelets platelet NNS cord-010092-uftc8inx 7047 19 . . . cord-010092-uftc8inx 7048 1 77 77 CD cord-010092-uftc8inx 7048 2 % % NN cord-010092-uftc8inx 7048 3 of of IN cord-010092-uftc8inx 7048 4 the the DT cord-010092-uftc8inx 7048 5 available available JJ cord-010092-uftc8inx 7048 6 BC BC NNP cord-010092-uftc8inx 7048 7 were be VBD cord-010092-uftc8inx 7048 8 used use VBN cord-010092-uftc8inx 7048 9 in in IN cord-010092-uftc8inx 7048 10 production production NN cord-010092-uftc8inx 7048 11 for for IN cord-010092-uftc8inx 7048 12 period period NN cord-010092-uftc8inx 7048 13 A a NN cord-010092-uftc8inx 7048 14 and and CC cord-010092-uftc8inx 7048 15 88 88 CD cord-010092-uftc8inx 7048 16 % % NN cord-010092-uftc8inx 7048 17 for for IN cord-010092-uftc8inx 7048 18 periods period NNS cord-010092-uftc8inx 7048 19 B b NN cord-010092-uftc8inx 7048 20 , , , cord-010092-uftc8inx 7048 21 C C NNP cord-010092-uftc8inx 7048 22 and and CC cord-010092-uftc8inx 7048 23 D. D. NNP cord-010092-uftc8inx 7049 1 After after IN cord-010092-uftc8inx 7049 2 wastes waste NNS cord-010092-uftc8inx 7049 3 of of IN cord-010092-uftc8inx 7049 4 approximately approximately RB cord-010092-uftc8inx 7049 5 1.9 1.9 CD cord-010092-uftc8inx 7049 6 % % NN cord-010092-uftc8inx 7049 7 , , , cord-010092-uftc8inx 7049 8 the the DT cord-010092-uftc8inx 7049 9 distribution distribution NN cord-010092-uftc8inx 7049 10 of of IN cord-010092-uftc8inx 7049 11 PC pc NN cord-010092-uftc8inx 7049 12 was be VBD cord-010092-uftc8inx 7049 13 stable stable JJ cord-010092-uftc8inx 7049 14 for for IN cord-010092-uftc8inx 7049 15 the the DT cord-010092-uftc8inx 7049 16 4 4 CD cord-010092-uftc8inx 7049 17 periods period NNS cord-010092-uftc8inx 7049 18 studied study VBN cord-010092-uftc8inx 7049 19 . . . cord-010092-uftc8inx 7050 1 7075 7075 CD cord-010092-uftc8inx 7050 2 PC pc NN cord-010092-uftc8inx 7050 3 were be VBD cord-010092-uftc8inx 7050 4 distributed distribute VBN cord-010092-uftc8inx 7050 5 for for IN cord-010092-uftc8inx 7050 6 period period NN cord-010092-uftc8inx 7050 7 A a NN cord-010092-uftc8inx 7050 8 , , , cord-010092-uftc8inx 7050 9 7047 7047 CD cord-010092-uftc8inx 7050 10 PC pc NN cord-010092-uftc8inx 7050 11 for for IN cord-010092-uftc8inx 7050 12 B b NN cord-010092-uftc8inx 7050 13 , , , cord-010092-uftc8inx 7050 14 7467 7467 CD cord-010092-uftc8inx 7050 15 PC pc NN cord-010092-uftc8inx 7050 16 for for IN cord-010092-uftc8inx 7050 17 C c NN cord-010092-uftc8inx 7050 18 and and CC cord-010092-uftc8inx 7050 19 7083 7083 CD cord-010092-uftc8inx 7050 20 PC pc NN cord-010092-uftc8inx 7050 21 for for IN cord-010092-uftc8inx 7050 22 D. D. NNP cord-010092-uftc8inx 7051 1 The the DT cord-010092-uftc8inx 7051 2 % % NN cord-010092-uftc8inx 7051 3 of of IN cord-010092-uftc8inx 7051 4 PI pi NN cord-010092-uftc8inx 7051 5 platelets platelet NNS cord-010092-uftc8inx 7051 6 with with IN cord-010092-uftc8inx 7051 7 7-day 7-day JJ cord-010092-uftc8inx 7051 8 shelf shelf NN cord-010092-uftc8inx 7051 9 life life NN cord-010092-uftc8inx 7051 10 available available JJ cord-010092-uftc8inx 7051 11 in in IN cord-010092-uftc8inx 7051 12 the the DT cord-010092-uftc8inx 7051 13 3 3 CD cord-010092-uftc8inx 7051 14 hospitals hospital NNS cord-010092-uftc8inx 7051 15 was be VBD cord-010092-uftc8inx 7051 16 limited limit VBN cord-010092-uftc8inx 7051 17 to to IN cord-010092-uftc8inx 7051 18 13 13 CD cord-010092-uftc8inx 7051 19 % % NN cord-010092-uftc8inx 7051 20 during during IN cord-010092-uftc8inx 7051 21 period period NN cord-010092-uftc8inx 7051 22 A. a. NN cord-010092-uftc8inx 7052 1 It -PRON- PRP cord-010092-uftc8inx 7052 2 was be VBD cord-010092-uftc8inx 7052 3 then then RB cord-010092-uftc8inx 7052 4 increased increase VBN cord-010092-uftc8inx 7052 5 to to IN cord-010092-uftc8inx 7052 6 14.1 14.1 CD cord-010092-uftc8inx 7052 7 % % NN cord-010092-uftc8inx 7052 8 , , , cord-010092-uftc8inx 7052 9 20.9 20.9 CD cord-010092-uftc8inx 7052 10 % % NN cord-010092-uftc8inx 7052 11 and and CC cord-010092-uftc8inx 7052 12 26 26 CD cord-010092-uftc8inx 7052 13 % % NN cord-010092-uftc8inx 7052 14 for for IN cord-010092-uftc8inx 7052 15 periods period NNS cord-010092-uftc8inx 7052 16 B b NN cord-010092-uftc8inx 7052 17 , , , cord-010092-uftc8inx 7052 18 C C NNP cord-010092-uftc8inx 7052 19 and and CC cord-010092-uftc8inx 7052 20 D D NNP cord-010092-uftc8inx 7052 21 respectively respectively RB cord-010092-uftc8inx 7052 22 . . . cord-010092-uftc8inx 7053 1 The the DT cord-010092-uftc8inx 7053 2 percentage percentage NN cord-010092-uftc8inx 7053 3 of of IN cord-010092-uftc8inx 7053 4 wastes waste NNS cord-010092-uftc8inx 7053 5 was be VBD cord-010092-uftc8inx 7053 6 stable stable JJ cord-010092-uftc8inx 7053 7 at at IN cord-010092-uftc8inx 7053 8 0.2 0.2 CD cord-010092-uftc8inx 7053 9 - - HYPH cord-010092-uftc8inx 7053 10 0.3 0.3 CD cord-010092-uftc8inx 7053 11 % % NN cord-010092-uftc8inx 7053 12 but but CC cord-010092-uftc8inx 7053 13 the the DT cord-010092-uftc8inx 7053 14 discards discard NNS cord-010092-uftc8inx 7053 15 due due IN cord-010092-uftc8inx 7053 16 to to IN cord-010092-uftc8inx 7053 17 expiry expiry NN cord-010092-uftc8inx 7053 18 went go VBD cord-010092-uftc8inx 7053 19 down down RB cord-010092-uftc8inx 7053 20 from from IN cord-010092-uftc8inx 7053 21 24.24 24.24 CD cord-010092-uftc8inx 7053 22 % % NN cord-010092-uftc8inx 7053 23 ( ( -LRB- cord-010092-uftc8inx 7053 24 period period NN cord-010092-uftc8inx 7053 25 A a NN cord-010092-uftc8inx 7053 26 ) ) -RRB- cord-010092-uftc8inx 7053 27 to to TO cord-010092-uftc8inx 7053 28 stabilize stabilize VB cord-010092-uftc8inx 7053 29 at at IN cord-010092-uftc8inx 7053 30 10.9 10.9 CD cord-010092-uftc8inx 7053 31 % % NN cord-010092-uftc8inx 7053 32 in in IN cord-010092-uftc8inx 7053 33 periods period NNS cord-010092-uftc8inx 7053 34 B b NN cord-010092-uftc8inx 7053 35 and and CC cord-010092-uftc8inx 7053 36 C c NN cord-010092-uftc8inx 7053 37 and and CC cord-010092-uftc8inx 7053 38 10.3 10.3 CD cord-010092-uftc8inx 7053 39 % % NN cord-010092-uftc8inx 7053 40 in in IN cord-010092-uftc8inx 7053 41 period period NN cord-010092-uftc8inx 7053 42 D. D. NNP cord-010092-uftc8inx 7054 1 In in IN cord-010092-uftc8inx 7054 2 the the DT cord-010092-uftc8inx 7054 3 3 3 CD cord-010092-uftc8inx 7054 4 general general JJ cord-010092-uftc8inx 7054 5 hospitals hospital NNS cord-010092-uftc8inx 7054 6 the the DT cord-010092-uftc8inx 7054 7 expiry expiry NN cord-010092-uftc8inx 7054 8 went go VBD cord-010092-uftc8inx 7054 9 down down RB cord-010092-uftc8inx 7054 10 from from IN cord-010092-uftc8inx 7054 11 20 20 CD cord-010092-uftc8inx 7054 12 % % NN cord-010092-uftc8inx 7054 13 to to IN cord-010092-uftc8inx 7054 14 5.89%(HCT 5.89%(hct CD cord-010092-uftc8inx 7054 15 ) ) -RRB- cord-010092-uftc8inx 7054 16 , , , cord-010092-uftc8inx 7054 17 29.4 29.4 CD cord-010092-uftc8inx 7054 18 % % NN cord-010092-uftc8inx 7054 19 to to IN cord-010092-uftc8inx 7054 20 14.5 14.5 CD cord-010092-uftc8inx 7054 21 % % NN cord-010092-uftc8inx 7054 22 ( ( -LRB- cord-010092-uftc8inx 7054 23 UGHG UGHG NNP cord-010092-uftc8inx 7054 24 ) ) -RRB- cord-010092-uftc8inx 7054 25 and and CC cord-010092-uftc8inx 7054 26 33.36 33.36 CD cord-010092-uftc8inx 7054 27 % % NN cord-010092-uftc8inx 7054 28 to to IN cord-010092-uftc8inx 7054 29 17.68%(NSPT 17.68%(nspt CD cord-010092-uftc8inx 7054 30 ) ) -RRB- cord-010092-uftc8inx 7054 31 respectively respectively RB cord-010092-uftc8inx 7054 32 . . . cord-010092-uftc8inx 7055 1 Summary Summary NNP cord-010092-uftc8inx 7055 2 / / SYM cord-010092-uftc8inx 7055 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 7055 4 : : : cord-010092-uftc8inx 7056 1 Greater great JJR cord-010092-uftc8inx 7056 2 control control NN cord-010092-uftc8inx 7056 3 of of IN cord-010092-uftc8inx 7056 4 PC pc NN cord-010092-uftc8inx 7056 5 stocks stock NNS cord-010092-uftc8inx 7056 6 through through IN cord-010092-uftc8inx 7056 7 historical historical JJ cord-010092-uftc8inx 7056 8 analysis analysis NN cord-010092-uftc8inx 7056 9 and and CC cord-010092-uftc8inx 7056 10 consumption consumption NN cord-010092-uftc8inx 7056 11 projection projection NN cord-010092-uftc8inx 7056 12 , , , cord-010092-uftc8inx 7056 13 together together RB cord-010092-uftc8inx 7056 14 with with IN cord-010092-uftc8inx 7056 15 IT IT NNP cord-010092-uftc8inx 7056 16 tools tool NNS cord-010092-uftc8inx 7056 17 and and CC cord-010092-uftc8inx 7056 18 the the DT cord-010092-uftc8inx 7056 19 use use NN cord-010092-uftc8inx 7056 20 of of IN cord-010092-uftc8inx 7056 21 PI PI NNP cord-010092-uftc8inx 7056 22 PC pc NN cord-010092-uftc8inx 7056 23 with with IN cord-010092-uftc8inx 7056 24 7-day 7-day JJ cord-010092-uftc8inx 7056 25 shelf shelf NN cord-010092-uftc8inx 7056 26 life life NN cord-010092-uftc8inx 7056 27 allowed allow VBD cord-010092-uftc8inx 7056 28 reducing reduce VBG cord-010092-uftc8inx 7056 29 discards discard NNS cord-010092-uftc8inx 7056 30 for for IN cord-010092-uftc8inx 7056 31 expiry expiry NN cord-010092-uftc8inx 7056 32 from from IN cord-010092-uftc8inx 7056 33 24.24 24.24 CD cord-010092-uftc8inx 7056 34 % % NN cord-010092-uftc8inx 7056 35 to to IN cord-010092-uftc8inx 7056 36 10.3 10.3 CD cord-010092-uftc8inx 7056 37 % % NN cord-010092-uftc8inx 7056 38 in in IN cord-010092-uftc8inx 7056 39 the the DT cord-010092-uftc8inx 7056 40 last last JJ cord-010092-uftc8inx 7056 41 period period NN cord-010092-uftc8inx 7056 42 analyzed analyze VBN cord-010092-uftc8inx 7056 43 at at IN cord-010092-uftc8inx 7056 44 RTC RTC NNP cord-010092-uftc8inx 7056 45 and and CC cord-010092-uftc8inx 7056 46 the the DT cord-010092-uftc8inx 7056 47 3 3 CD cord-010092-uftc8inx 7056 48 major major JJ cord-010092-uftc8inx 7056 49 hospitals hospital NNS cord-010092-uftc8inx 7056 50 of of IN cord-010092-uftc8inx 7056 51 the the DT cord-010092-uftc8inx 7056 52 hemotherapy hemotherapy NNP cord-010092-uftc8inx 7056 53 area area NN cord-010092-uftc8inx 7056 54 . . . cord-010092-uftc8inx 7057 1 This this DT cord-010092-uftc8inx 7057 2 has have VBZ cord-010092-uftc8inx 7057 3 a a DT cord-010092-uftc8inx 7057 4 great great JJ cord-010092-uftc8inx 7057 5 value value NN cord-010092-uftc8inx 7057 6 in in IN cord-010092-uftc8inx 7057 7 cost cost NN cord-010092-uftc8inx 7057 8 - - HYPH cord-010092-uftc8inx 7057 9 reduction reduction NN cord-010092-uftc8inx 7057 10 and and CC cord-010092-uftc8inx 7057 11 improves improve VBZ cord-010092-uftc8inx 7057 12 inventory inventory NN cord-010092-uftc8inx 7057 13 management management NN cord-010092-uftc8inx 7057 14 and and CC cord-010092-uftc8inx 7057 15 the the DT cord-010092-uftc8inx 7057 16 efficiency efficiency NN cord-010092-uftc8inx 7057 17 of of IN cord-010092-uftc8inx 7057 18 the the DT cord-010092-uftc8inx 7057 19 processes process NNS cord-010092-uftc8inx 7057 20 . . . cord-010092-uftc8inx 7058 1 Background background NN cord-010092-uftc8inx 7058 2 : : : cord-010092-uftc8inx 7059 1 Blood blood NN cord-010092-uftc8inx 7059 2 centers center NNS cord-010092-uftc8inx 7059 3 are be VBP cord-010092-uftc8inx 7059 4 faced face VBN cord-010092-uftc8inx 7059 5 with with IN cord-010092-uftc8inx 7059 6 many many JJ cord-010092-uftc8inx 7059 7 challenges challenge NNS cord-010092-uftc8inx 7059 8 including include VBG cord-010092-uftc8inx 7059 9 availability availability NN cord-010092-uftc8inx 7059 10 of of IN cord-010092-uftc8inx 7059 11 concentrate concentrate NN cord-010092-uftc8inx 7059 12 platelets platelet NNS cord-010092-uftc8inx 7059 13 as as RB cord-010092-uftc8inx 7059 14 well well RB cord-010092-uftc8inx 7059 15 as as IN cord-010092-uftc8inx 7059 16 ensuring ensure VBG cord-010092-uftc8inx 7059 17 highest high JJS cord-010092-uftc8inx 7059 18 quality quality NN cord-010092-uftc8inx 7059 19 of of IN cord-010092-uftc8inx 7059 20 the the DT cord-010092-uftc8inx 7059 21 product product NN cord-010092-uftc8inx 7059 22 . . . cord-010092-uftc8inx 7060 1 Overcoming overcome VBG cord-010092-uftc8inx 7060 2 the the DT cord-010092-uftc8inx 7060 3 shortage shortage NN cord-010092-uftc8inx 7060 4 of of IN cord-010092-uftc8inx 7060 5 platelet platelet NN cord-010092-uftc8inx 7060 6 apheresis apheresis NN cord-010092-uftc8inx 7060 7 by by IN cord-010092-uftc8inx 7060 8 using use VBG cord-010092-uftc8inx 7060 9 pooled pool VBN cord-010092-uftc8inx 7060 10 platelet platelet NN cord-010092-uftc8inx 7060 11 derived derive VBN cord-010092-uftc8inx 7060 12 from from IN cord-010092-uftc8inx 7060 13 whole whole JJ cord-010092-uftc8inx 7060 14 blood blood NN cord-010092-uftc8inx 7060 15 units unit NNS cord-010092-uftc8inx 7060 16 separated separate VBD cord-010092-uftc8inx 7060 17 using use VBG cord-010092-uftc8inx 7060 18 automated automate VBN cord-010092-uftc8inx 7060 19 standardized standardized JJ cord-010092-uftc8inx 7060 20 system system NN cord-010092-uftc8inx 7060 21 , , , cord-010092-uftc8inx 7060 22 which which WDT cord-010092-uftc8inx 7060 23 can can MD cord-010092-uftc8inx 7060 24 assist assist VB cord-010092-uftc8inx 7060 25 blood blood NN cord-010092-uftc8inx 7060 26 banks bank NNS cord-010092-uftc8inx 7060 27 to to TO cord-010092-uftc8inx 7060 28 meet meet VB cord-010092-uftc8inx 7060 29 the the DT cord-010092-uftc8inx 7060 30 increase increase NN cord-010092-uftc8inx 7060 31 demand demand NN cord-010092-uftc8inx 7060 32 in in IN cord-010092-uftc8inx 7060 33 platelets platelet NNS cord-010092-uftc8inx 7060 34 . . . cord-010092-uftc8inx 7061 1 The the DT cord-010092-uftc8inx 7061 2 Pathogen Pathogen NNP cord-010092-uftc8inx 7061 3 inactivation inactivation NN cord-010092-uftc8inx 7061 4 ( ( -LRB- cord-010092-uftc8inx 7061 5 PI pi NN cord-010092-uftc8inx 7061 6 ) ) -RRB- cord-010092-uftc8inx 7061 7 technology technology NN cord-010092-uftc8inx 7061 8 can can MD cord-010092-uftc8inx 7061 9 improve improve VB cord-010092-uftc8inx 7061 10 the the DT cord-010092-uftc8inx 7061 11 quality quality NN cord-010092-uftc8inx 7061 12 of of IN cord-010092-uftc8inx 7061 13 the the DT cord-010092-uftc8inx 7061 14 product product NN cord-010092-uftc8inx 7061 15 by by IN cord-010092-uftc8inx 7061 16 mitigating mitigate VBG cord-010092-uftc8inx 7061 17 the the DT cord-010092-uftc8inx 7061 18 risk risk NN cord-010092-uftc8inx 7061 19 of of IN cord-010092-uftc8inx 7061 20 transfusion transfusion NN cord-010092-uftc8inx 7061 21 - - HYPH cord-010092-uftc8inx 7061 22 transmitted transmit VBN cord-010092-uftc8inx 7061 23 diseases disease NNS cord-010092-uftc8inx 7061 24 ( ( -LRB- cord-010092-uftc8inx 7061 25 TTD TTD NNP cord-010092-uftc8inx 7061 26 ) ) -RRB- cord-010092-uftc8inx 7061 27 and and CC cord-010092-uftc8inx 7061 28 residual residual JJ cord-010092-uftc8inx 7061 29 white white JJ cord-010092-uftc8inx 7061 30 cells cell NNS cord-010092-uftc8inx 7061 31 , , , cord-010092-uftc8inx 7061 32 resulting result VBG cord-010092-uftc8inx 7061 33 in in IN cord-010092-uftc8inx 7061 34 minimizing minimize VBG cord-010092-uftc8inx 7061 35 non non JJ cord-010092-uftc8inx 7061 36 -hemolytic -hemolytic JJ cord-010092-uftc8inx 7061 37 transfusion transfusion NN cord-010092-uftc8inx 7061 38 reactions reaction NNS cord-010092-uftc8inx 7061 39 . . . cord-010092-uftc8inx 7062 1 However however RB cord-010092-uftc8inx 7062 2 , , , cord-010092-uftc8inx 7062 3 the the DT cord-010092-uftc8inx 7062 4 pathogen pathogen NN cord-010092-uftc8inx 7062 5 inactivation inactivation NN cord-010092-uftc8inx 7062 6 treatment treatment NN cord-010092-uftc8inx 7062 7 must must MD cord-010092-uftc8inx 7062 8 not not RB cord-010092-uftc8inx 7062 9 impact impact VB cord-010092-uftc8inx 7062 10 the the DT cord-010092-uftc8inx 7062 11 platelet platelet NN cord-010092-uftc8inx 7062 12 quality quality NN cord-010092-uftc8inx 7062 13 and and CC cord-010092-uftc8inx 7062 14 functionality functionality NN cord-010092-uftc8inx 7062 15 significantly significantly RB cord-010092-uftc8inx 7062 16 , , , cord-010092-uftc8inx 7062 17 as as RB cord-010092-uftc8inx 7062 18 well well RB cord-010092-uftc8inx 7062 19 as as IN cord-010092-uftc8inx 7062 20 the the DT cord-010092-uftc8inx 7062 21 patient patient NN cord-010092-uftc8inx 7062 22 safety safety NN cord-010092-uftc8inx 7062 23 . . . cord-010092-uftc8inx 7063 1 Aims aim NNS cord-010092-uftc8inx 7063 2 : : : cord-010092-uftc8inx 7063 3 Evaluate evaluate VB cord-010092-uftc8inx 7063 4 the the DT cord-010092-uftc8inx 7063 5 quality quality NN cord-010092-uftc8inx 7063 6 of of IN cord-010092-uftc8inx 7063 7 pooled pool VBN cord-010092-uftc8inx 7063 8 platelets platelet NNS cord-010092-uftc8inx 7063 9 derived derive VBN cord-010092-uftc8inx 7063 10 from from IN cord-010092-uftc8inx 7063 11 whole whole JJ cord-010092-uftc8inx 7063 12 blood blood NN cord-010092-uftc8inx 7063 13 ( ( -LRB- cord-010092-uftc8inx 7063 14 five five CD cord-010092-uftc8inx 7063 15 interim interim JJ cord-010092-uftc8inx 7063 16 platelet platelet NN cord-010092-uftc8inx 7063 17 units unit NNS cord-010092-uftc8inx 7063 18 ) ) -RRB- cord-010092-uftc8inx 7063 19 , , , cord-010092-uftc8inx 7063 20 separated separate VBD cord-010092-uftc8inx 7063 21 using use VBG cord-010092-uftc8inx 7063 22 Reveos Reveos NNP cord-010092-uftc8inx 7063 23 Automated Automated NNP cord-010092-uftc8inx 7063 24 Blood Blood NNP cord-010092-uftc8inx 7063 25 Processing Processing NNP cord-010092-uftc8inx 7063 26 system system NN cord-010092-uftc8inx 7063 27 ( ( -LRB- cord-010092-uftc8inx 7063 28 Terumo Terumo NNP cord-010092-uftc8inx 7063 29 BCT BCT NNP cord-010092-uftc8inx 7063 30 ) ) -RRB- cord-010092-uftc8inx 7063 31 , , , cord-010092-uftc8inx 7063 32 pooled pool VBN cord-010092-uftc8inx 7063 33 in in IN cord-010092-uftc8inx 7063 34 100 100 CD cord-010092-uftc8inx 7063 35 % % NN cord-010092-uftc8inx 7063 36 donor donor NN cord-010092-uftc8inx 7063 37 plasma plasma NN cord-010092-uftc8inx 7063 38 and and CC cord-010092-uftc8inx 7063 39 pathogen pathogen NN cord-010092-uftc8inx 7063 40 inactivated inactivate VBN cord-010092-uftc8inx 7063 41 by by IN cord-010092-uftc8inx 7063 42 amotosalen amotosalen NNP cord-010092-uftc8inx 7063 43 / / SYM cord-010092-uftc8inx 7063 44 UVA UVA NNP cord-010092-uftc8inx 7063 45 technology technology NN cord-010092-uftc8inx 7063 46 . . . cord-010092-uftc8inx 7064 1 Methods method NNS cord-010092-uftc8inx 7064 2 : : : cord-010092-uftc8inx 7064 3 Five five CD cord-010092-uftc8inx 7064 4 interim interim JJ cord-010092-uftc8inx 7064 5 platelet platelet NN cord-010092-uftc8inx 7064 6 units unit NNS cord-010092-uftc8inx 7064 7 ( ( -LRB- cord-010092-uftc8inx 7064 8 IPUs ipu NNS cord-010092-uftc8inx 7064 9 ) ) -RRB- cord-010092-uftc8inx 7064 10 produced produce VBN cord-010092-uftc8inx 7064 11 with with IN cord-010092-uftc8inx 7064 12 Reveos Reveos NNP cord-010092-uftc8inx 7064 13 device device NN cord-010092-uftc8inx 7064 14 ( ( -LRB- cord-010092-uftc8inx 7064 15 Terumo Terumo NNP cord-010092-uftc8inx 7064 16 BCT BCT NNP cord-010092-uftc8inx 7064 17 ) ) -RRB- cord-010092-uftc8inx 7064 18 from from IN cord-010092-uftc8inx 7064 19 single single JJ cord-010092-uftc8inx 7064 20 whole whole JJ cord-010092-uftc8inx 7064 21 blood blood NN cord-010092-uftc8inx 7064 22 donations donation NNS cord-010092-uftc8inx 7064 23 , , , cord-010092-uftc8inx 7064 24 were be VBD cord-010092-uftc8inx 7064 25 pooled pool VBN cord-010092-uftc8inx 7064 26 with with IN cord-010092-uftc8inx 7064 27 a a DT cord-010092-uftc8inx 7064 28 Platelet platelet NN cord-010092-uftc8inx 7064 29 Pooling pooling NN cord-010092-uftc8inx 7064 30 Set set NN cord-010092-uftc8inx 7064 31 ( ( -LRB- cord-010092-uftc8inx 7064 32 Terumo Terumo NNP cord-010092-uftc8inx 7064 33 BCT BCT NNP cord-010092-uftc8inx 7064 34 ) ) -RRB- cord-010092-uftc8inx 7064 35 and and CC cord-010092-uftc8inx 7064 36 leucodepleted leucodeplete VBD cord-010092-uftc8inx 7064 37 with with IN cord-010092-uftc8inx 7064 38 a a DT cord-010092-uftc8inx 7064 39 LRF LRF NNP cord-010092-uftc8inx 7064 40 - - HYPH cord-010092-uftc8inx 7064 41 XL XL NNP cord-010092-uftc8inx 7064 42 filter filter NN cord-010092-uftc8inx 7064 43 ( ( -LRB- cord-010092-uftc8inx 7064 44 Haemonetics Haemonetics NNP cord-010092-uftc8inx 7064 45 ) ) -RRB- cord-010092-uftc8inx 7064 46 . . . cord-010092-uftc8inx 7065 1 Thirty thirty CD cord-010092-uftc8inx 7065 2 pools pool NNS cord-010092-uftc8inx 7065 3 have have VBP cord-010092-uftc8inx 7065 4 been be VBN cord-010092-uftc8inx 7065 5 included include VBN cord-010092-uftc8inx 7065 6 in in IN cord-010092-uftc8inx 7065 7 this this DT cord-010092-uftc8inx 7065 8 study study NN cord-010092-uftc8inx 7065 9 , , , cord-010092-uftc8inx 7065 10 the the DT cord-010092-uftc8inx 7065 11 units unit NNS cord-010092-uftc8inx 7065 12 were be VBD cord-010092-uftc8inx 7065 13 treated treat VBN cord-010092-uftc8inx 7065 14 using use VBG cord-010092-uftc8inx 7065 15 a a DT cord-010092-uftc8inx 7065 16 Large large JJ cord-010092-uftc8inx 7065 17 Volume volume NN cord-010092-uftc8inx 7065 18 Cerus Cerus NNP cord-010092-uftc8inx 7065 19 INTERCEPT INTERCEPT NNP cord-010092-uftc8inx 7065 20 Processing processing NN cord-010092-uftc8inx 7065 21 Set Set VBN cord-010092-uftc8inx 7065 22 for for IN cord-010092-uftc8inx 7065 23 Platelets platelet NNS cord-010092-uftc8inx 7065 24 according accord VBG cord-010092-uftc8inx 7065 25 to to IN cord-010092-uftc8inx 7065 26 the the DT cord-010092-uftc8inx 7065 27 manufacturer manufacturer NN cord-010092-uftc8inx 7065 28 's 's POS cord-010092-uftc8inx 7065 29 instructions instruction NNS cord-010092-uftc8inx 7065 30 and and CC cord-010092-uftc8inx 7065 31 stored store VBN cord-010092-uftc8inx 7065 32 until until IN cord-010092-uftc8inx 7065 33 day day NN cord-010092-uftc8inx 7065 34 5 5 CD cord-010092-uftc8inx 7065 35 . . . cord-010092-uftc8inx 7066 1 The the DT cord-010092-uftc8inx 7066 2 swirling swirling NN cord-010092-uftc8inx 7066 3 was be VBD cord-010092-uftc8inx 7066 4 determined determine VBN cord-010092-uftc8inx 7066 5 by by IN cord-010092-uftc8inx 7066 6 visual visual JJ cord-010092-uftc8inx 7066 7 inspection inspection NN cord-010092-uftc8inx 7066 8 . . . cord-010092-uftc8inx 7067 1 The the DT cord-010092-uftc8inx 7067 2 volume volume NN cord-010092-uftc8inx 7067 3 and and CC cord-010092-uftc8inx 7067 4 yield yield NN cord-010092-uftc8inx 7067 5 content content NN cord-010092-uftc8inx 7067 6 were be VBD cord-010092-uftc8inx 7067 7 assessed assess VBN cord-010092-uftc8inx 7067 8 preinactivation preinactivation NN cord-010092-uftc8inx 7067 9 and and CC cord-010092-uftc8inx 7067 10 after after IN cord-010092-uftc8inx 7067 11 treatment treatment NN cord-010092-uftc8inx 7067 12 by by IN cord-010092-uftc8inx 7067 13 pathogen pathogen NN cord-010092-uftc8inx 7067 14 inactivation inactivation NN cord-010092-uftc8inx 7067 15 with with IN cord-010092-uftc8inx 7067 16 a a DT cord-010092-uftc8inx 7067 17 cell cell NN cord-010092-uftc8inx 7067 18 counter counter NN cord-010092-uftc8inx 7067 19 ( ( -LRB- cord-010092-uftc8inx 7067 20 DXH-800 dxh-800 FW cord-010092-uftc8inx 7067 21 , , , cord-010092-uftc8inx 7067 22 Beckman Beckman NNP cord-010092-uftc8inx 7067 23 Coulter Coulter NNP cord-010092-uftc8inx 7067 24 ) ) -RRB- cord-010092-uftc8inx 7067 25 , , , cord-010092-uftc8inx 7067 26 RBC RBC NNP cord-010092-uftc8inx 7067 27 contamination contamination NN cord-010092-uftc8inx 7067 28 was be VBD cord-010092-uftc8inx 7067 29 also also RB cord-010092-uftc8inx 7067 30 measured measure VBN cord-010092-uftc8inx 7067 31 preinactivation preinactivation NN cord-010092-uftc8inx 7067 32 with with IN cord-010092-uftc8inx 7067 33 a a DT cord-010092-uftc8inx 7067 34 cell cell NN cord-010092-uftc8inx 7067 35 counter counter NN cord-010092-uftc8inx 7067 36 ( ( -LRB- cord-010092-uftc8inx 7067 37 Beckman Beckman NNP cord-010092-uftc8inx 7067 38 Coulter Coulter NNP cord-010092-uftc8inx 7067 39 ) ) -RRB- cord-010092-uftc8inx 7067 40 , , , cord-010092-uftc8inx 7067 41 bacterial bacterial JJ cord-010092-uftc8inx 7067 42 contamination contamination NN cord-010092-uftc8inx 7067 43 was be VBD cord-010092-uftc8inx 7067 44 assessed assess VBN cord-010092-uftc8inx 7067 45 by by IN cord-010092-uftc8inx 7067 46 automated automated JJ cord-010092-uftc8inx 7067 47 blood blood NN cord-010092-uftc8inx 7067 48 culture culture NN cord-010092-uftc8inx 7067 49 with with IN cord-010092-uftc8inx 7067 50 a a DT cord-010092-uftc8inx 7067 51 BacT/ BacT/ NNP cord-010092-uftc8inx 7067 52 ALERT alert NN cord-010092-uftc8inx 7067 53 system system NN cord-010092-uftc8inx 7067 54 ( ( -LRB- cord-010092-uftc8inx 7067 55 Biomerieux Biomerieux NNP cord-010092-uftc8inx 7067 56 ) ) -RRB- cord-010092-uftc8inx 7067 57 . . . cord-010092-uftc8inx 7068 1 The the DT cord-010092-uftc8inx 7068 2 pH ph NN cord-010092-uftc8inx 7068 3 of of IN cord-010092-uftc8inx 7068 4 the the DT cord-010092-uftc8inx 7068 5 platelet platelet NN cord-010092-uftc8inx 7068 6 units unit NNS cord-010092-uftc8inx 7068 7 was be VBD cord-010092-uftc8inx 7068 8 assessed assess VBN cord-010092-uftc8inx 7068 9 with with IN cord-010092-uftc8inx 7068 10 a a DT cord-010092-uftc8inx 7068 11 pHmeter pHmeter NNP cord-010092-uftc8inx 7068 12 ( ( -LRB- cord-010092-uftc8inx 7068 13 Jenway Jenway NNP cord-010092-uftc8inx 7068 14 ) ) -RRB- cord-010092-uftc8inx 7068 15 , , , cord-010092-uftc8inx 7068 16 and and CC cord-010092-uftc8inx 7068 17 residual residual JJ cord-010092-uftc8inx 7068 18 Amotosalen Amotosalen NNP cord-010092-uftc8inx 7068 19 levels level NNS cord-010092-uftc8inx 7068 20 were be VBD cord-010092-uftc8inx 7068 21 assessed assess VBN cord-010092-uftc8inx 7068 22 by by IN cord-010092-uftc8inx 7068 23 an an DT cord-010092-uftc8inx 7068 24 HPLC HPLC NNP cord-010092-uftc8inx 7068 25 assay assay NN cord-010092-uftc8inx 7068 26 . . . cord-010092-uftc8inx 7069 1 Results result NNS cord-010092-uftc8inx 7069 2 : : : cord-010092-uftc8inx 7070 1 The the DT cord-010092-uftc8inx 7070 2 impact impact NN cord-010092-uftc8inx 7070 3 of of IN cord-010092-uftc8inx 7070 4 Amotosalen Amotosalen NNP cord-010092-uftc8inx 7070 5 / / SYM cord-010092-uftc8inx 7070 6 UVA UVA NNP cord-010092-uftc8inx 7070 7 pathogen pathogen NN cord-010092-uftc8inx 7070 8 - - HYPH cord-010092-uftc8inx 7070 9 inactivated inactivate VBN cord-010092-uftc8inx 7070 10 pool pool NN cord-010092-uftc8inx 7070 11 platelet platelet NN cord-010092-uftc8inx 7070 12 products product NNS cord-010092-uftc8inx 7070 13 quality quality NN cord-010092-uftc8inx 7070 14 were be VBD cord-010092-uftc8inx 7070 15 assessed assess VBN cord-010092-uftc8inx 7070 16 . . . cord-010092-uftc8inx 7071 1 The the DT cord-010092-uftc8inx 7071 2 pre pre JJ cord-010092-uftc8inx 7071 3 and and CC cord-010092-uftc8inx 7071 4 post post JJ cord-010092-uftc8inx 7071 5 - - NN cord-010092-uftc8inx 7071 6 inactivation inactivation JJ cord-010092-uftc8inx 7071 7 of of IN cord-010092-uftc8inx 7071 8 the the DT cord-010092-uftc8inx 7071 9 units unit NNS cord-010092-uftc8inx 7071 10 showed show VBD cord-010092-uftc8inx 7071 11 a a DT cord-010092-uftc8inx 7071 12 swirling swirling JJ cord-010092-uftc8inx 7071 13 score score NN cord-010092-uftc8inx 7071 14 of of IN cord-010092-uftc8inx 7071 15 2 2 CD cord-010092-uftc8inx 7071 16 - - SYM cord-010092-uftc8inx 7071 17 3 3 CD cord-010092-uftc8inx 7071 18 . . . cord-010092-uftc8inx 7072 1 The the DT cord-010092-uftc8inx 7072 2 average average JJ cord-010092-uftc8inx 7072 3 volume volume NN cord-010092-uftc8inx 7072 4 per per IN cord-010092-uftc8inx 7072 5 unit unit NN cord-010092-uftc8inx 7072 6 of of IN cord-010092-uftc8inx 7072 7 the the DT cord-010092-uftc8inx 7072 8 pre pre NN cord-010092-uftc8inx 7072 9 - - NN cord-010092-uftc8inx 7072 10 inactivation inactivation JJ cord-010092-uftc8inx 7072 11 was be VBD cord-010092-uftc8inx 7072 12 288 288 CD cord-010092-uftc8inx 7072 13 ml ml NN cord-010092-uftc8inx 7072 14 ( ( -LRB- cord-010092-uftc8inx 7072 15 278 278 CD cord-010092-uftc8inx 7072 16 - - SYM cord-010092-uftc8inx 7072 17 302 302 CD cord-010092-uftc8inx 7072 18 ml ml NN cord-010092-uftc8inx 7072 19 ) ) -RRB- cord-010092-uftc8inx 7072 20 and and CC cord-010092-uftc8inx 7072 21 post post NN cord-010092-uftc8inx 7072 22 inactivation inactivation NN cord-010092-uftc8inx 7072 23 was be VBD cord-010092-uftc8inx 7072 24 269 269 CD cord-010092-uftc8inx 7072 25 ml ml NNS cord-010092-uftc8inx 7072 26 ( ( -LRB- cord-010092-uftc8inx 7072 27 254 254 CD cord-010092-uftc8inx 7072 28 - - SYM cord-010092-uftc8inx 7072 29 284 284 CD cord-010092-uftc8inx 7072 30 ml ml NNS cord-010092-uftc8inx 7072 31 ) ) -RRB- cord-010092-uftc8inx 7072 32 , , , cord-010092-uftc8inx 7072 33 with with IN cord-010092-uftc8inx 7072 34 average average JJ cord-010092-uftc8inx 7072 35 volume volume NN cord-010092-uftc8inx 7072 36 loss loss NN cord-010092-uftc8inx 7072 37 during during IN cord-010092-uftc8inx 7072 38 inactivation inactivation NN cord-010092-uftc8inx 7072 39 was be VBD cord-010092-uftc8inx 7072 40 36 36 CD cord-010092-uftc8inx 7072 41 mL ml NN cord-010092-uftc8inx 7072 42 ( ( -LRB- cord-010092-uftc8inx 7072 43 24 24 CD cord-010092-uftc8inx 7072 44 - - SYM cord-010092-uftc8inx 7072 45 43 43 CD cord-010092-uftc8inx 7072 46 mL mL NNS cord-010092-uftc8inx 7072 47 ) ) -RRB- cord-010092-uftc8inx 7072 48 , , , cord-010092-uftc8inx 7072 49 corresponding correspond VBG cord-010092-uftc8inx 7072 50 to to IN cord-010092-uftc8inx 7072 51 13 13 CD cord-010092-uftc8inx 7072 52 % % NN cord-010092-uftc8inx 7072 53 ( ( -LRB- cord-010092-uftc8inx 7072 54 8 8 CD cord-010092-uftc8inx 7072 55 - - SYM cord-010092-uftc8inx 7072 56 15 15 CD cord-010092-uftc8inx 7072 57 % % NN cord-010092-uftc8inx 7072 58 ) ) -RRB- cord-010092-uftc8inx 7072 59 . . . cord-010092-uftc8inx 7073 1 The the DT cord-010092-uftc8inx 7073 2 average average JJ cord-010092-uftc8inx 7073 3 platelet platelet NN cord-010092-uftc8inx 7073 4 yield yield NN cord-010092-uftc8inx 7073 5 per per IN cord-010092-uftc8inx 7073 6 unit unit NN cord-010092-uftc8inx 7073 7 pre pre NN cord-010092-uftc8inx 7073 8 - - NNS cord-010092-uftc8inx 7073 9 inactivation inactivation JJ cord-010092-uftc8inx 7073 10 was be VBD cord-010092-uftc8inx 7073 11 3.7 3.7 CD cord-010092-uftc8inx 7073 12 9 9 CD cord-010092-uftc8inx 7073 13 10 10 CD cord-010092-uftc8inx 7073 14 11 11 CD cord-010092-uftc8inx 7074 1 ( ( -LRB- cord-010092-uftc8inx 7074 2 3.0 3.0 CD cord-010092-uftc8inx 7074 3 - - SYM cord-010092-uftc8inx 7074 4 4.4 4.4 CD cord-010092-uftc8inx 7074 5 9 9 CD cord-010092-uftc8inx 7074 6 10 10 CD cord-010092-uftc8inx 7074 7 11 11 CD cord-010092-uftc8inx 7074 8 ) ) -RRB- cord-010092-uftc8inx 7074 9 and and CC cord-010092-uftc8inx 7074 10 post post NN cord-010092-uftc8inx 7074 11 inactivation inactivation NN cord-010092-uftc8inx 7075 1 3.2 3.2 CD cord-010092-uftc8inx 7075 2 9 9 CD cord-010092-uftc8inx 7075 3 10 10 CD cord-010092-uftc8inx 7075 4 11 11 CD cord-010092-uftc8inx 7075 5 ( ( -LRB- cord-010092-uftc8inx 7075 6 2.8 2.8 CD cord-010092-uftc8inx 7075 7 - - SYM cord-010092-uftc8inx 7075 8 3.9 3.9 CD cord-010092-uftc8inx 7075 9 9 9 CD cord-010092-uftc8inx 7075 10 10 10 CD cord-010092-uftc8inx 7075 11 11 11 CD cord-010092-uftc8inx 7075 12 ) ) -RRB- cord-010092-uftc8inx 7075 13 with with IN cord-010092-uftc8inx 7075 14 an an DT cord-010092-uftc8inx 7075 15 average average JJ cord-010092-uftc8inx 7075 16 platelet platelet NN cord-010092-uftc8inx 7075 17 loss loss NN cord-010092-uftc8inx 7075 18 of of IN cord-010092-uftc8inx 7075 19 13 13 CD cord-010092-uftc8inx 7075 20 % % NN cord-010092-uftc8inx 7075 21 ( ( -LRB- cord-010092-uftc8inx 7075 22 3 3 CD cord-010092-uftc8inx 7075 23 - - SYM cord-010092-uftc8inx 7075 24 20 20 CD cord-010092-uftc8inx 7075 25 % % NN cord-010092-uftc8inx 7075 26 ) ) -RRB- cord-010092-uftc8inx 7075 27 . . . cord-010092-uftc8inx 7076 1 The the DT cord-010092-uftc8inx 7076 2 average average JJ cord-010092-uftc8inx 7076 3 RBC RBC NNP cord-010092-uftc8inx 7076 4 contamination contamination NN cord-010092-uftc8inx 7076 5 per per IN cord-010092-uftc8inx 7076 6 unit unit NN cord-010092-uftc8inx 7076 7 ( ( -LRB- cord-010092-uftc8inx 7076 8 0.01 0.01 CD cord-010092-uftc8inx 7076 9 - - SYM cord-010092-uftc8inx 7076 10 0.02 0.02 CD cord-010092-uftc8inx 7076 11 9 9 CD cord-010092-uftc8inx 7076 12 10 10 CD cord-010092-uftc8inx 7076 13 9 9 CD cord-010092-uftc8inx 7076 14 RBC RBC NNP cord-010092-uftc8inx 7076 15 / / SYM cord-010092-uftc8inx 7076 16 ml ml NN cord-010092-uftc8inx 7076 17 ) ) -RRB- cord-010092-uftc8inx 7076 18 . . . cord-010092-uftc8inx 7077 1 The the DT cord-010092-uftc8inx 7077 2 culture culture NN cord-010092-uftc8inx 7077 3 tests test NNS cord-010092-uftc8inx 7077 4 were be VBD cord-010092-uftc8inx 7077 5 negative negative JJ cord-010092-uftc8inx 7077 6 , , , cord-010092-uftc8inx 7077 7 the the DT cord-010092-uftc8inx 7077 8 average average JJ cord-010092-uftc8inx 7077 9 pH ph NN cord-010092-uftc8inx 7077 10 at at IN cord-010092-uftc8inx 7077 11 day day NN cord-010092-uftc8inx 7077 12 1 1 CD cord-010092-uftc8inx 7077 13 was be VBD cord-010092-uftc8inx 7077 14 7.4 7.4 CD cord-010092-uftc8inx 7077 15 ( ( -LRB- cord-010092-uftc8inx 7077 16 7.1 7.1 CD cord-010092-uftc8inx 7077 17 - - SYM cord-010092-uftc8inx 7077 18 7.6 7.6 CD cord-010092-uftc8inx 7077 19 ) ) -RRB- cord-010092-uftc8inx 7077 20 , , , cord-010092-uftc8inx 7077 21 average average JJ cord-010092-uftc8inx 7077 22 pH pH NNP cord-010092-uftc8inx 7078 1 at at IN cord-010092-uftc8inx 7078 2 day day NN cord-010092-uftc8inx 7078 3 4/5 4/5 CD cord-010092-uftc8inx 7078 4 was be VBD cord-010092-uftc8inx 7078 5 7.3 7.3 CD cord-010092-uftc8inx 7078 6 ( ( -LRB- cord-010092-uftc8inx 7078 7 7 7 CD cord-010092-uftc8inx 7078 8 . . CD cord-010092-uftc8inx 7078 9 2 2 CD cord-010092-uftc8inx 7078 10 - - SYM cord-010092-uftc8inx 7078 11 7.4 7.4 CD cord-010092-uftc8inx 7078 12 ) ) -RRB- cord-010092-uftc8inx 7078 13 . . . cord-010092-uftc8inx 7079 1 The the DT cord-010092-uftc8inx 7079 2 average average JJ cord-010092-uftc8inx 7079 3 residual residual NN cord-010092-uftc8inx 7079 4 Amotosalen Amotosalen NNP cord-010092-uftc8inx 7079 5 concentration concentration NN cord-010092-uftc8inx 7079 6 post post NN cord-010092-uftc8inx 7079 7 treatment treatment NN cord-010092-uftc8inx 7079 8 was be VBD cord-010092-uftc8inx 7079 9 0.30 0.30 CD cord-010092-uftc8inx 7079 10 lM lm NN cord-010092-uftc8inx 7080 1 ( ( -LRB- cord-010092-uftc8inx 7080 2 0.23 0.23 CD cord-010092-uftc8inx 7080 3 - - SYM cord-010092-uftc8inx 7080 4 0.35 0.35 CD cord-010092-uftc8inx 7080 5 lM lm NN cord-010092-uftc8inx 7080 6 ) ) -RRB- cord-010092-uftc8inx 7080 7 . . . cord-010092-uftc8inx 7081 1 Summary Summary NNP cord-010092-uftc8inx 7081 2 / / SYM cord-010092-uftc8inx 7081 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 7081 4 : : : cord-010092-uftc8inx 7082 1 The the DT cord-010092-uftc8inx 7082 2 quality quality NN cord-010092-uftc8inx 7082 3 of of IN cord-010092-uftc8inx 7082 4 pathogen pathogen NN cord-010092-uftc8inx 7082 5 - - HYPH cord-010092-uftc8inx 7082 6 inactivated inactivate VBN cord-010092-uftc8inx 7082 7 pool pool NN cord-010092-uftc8inx 7082 8 platelets platelet NNS cord-010092-uftc8inx 7082 9 tested test VBN cord-010092-uftc8inx 7082 10 , , , cord-010092-uftc8inx 7082 11 met meet VBD cord-010092-uftc8inx 7082 12 the the DT cord-010092-uftc8inx 7082 13 criteria criterion NNS cord-010092-uftc8inx 7082 14 set set VBN cord-010092-uftc8inx 7082 15 by by IN cord-010092-uftc8inx 7082 16 AABB AABB NNP cord-010092-uftc8inx 7082 17 guidelines guideline NNS cord-010092-uftc8inx 7082 18 . . . cord-010092-uftc8inx 7083 1 The the DT cord-010092-uftc8inx 7083 2 volume volume NN cord-010092-uftc8inx 7083 3 and and CC cord-010092-uftc8inx 7083 4 platelet platelet NN cord-010092-uftc8inx 7083 5 loss loss NN cord-010092-uftc8inx 7083 6 were be VBD cord-010092-uftc8inx 7083 7 in in IN cord-010092-uftc8inx 7083 8 acceptable acceptable JJ cord-010092-uftc8inx 7083 9 range range NN cord-010092-uftc8inx 7083 10 , , , cord-010092-uftc8inx 7083 11 in in IN cord-010092-uftc8inx 7083 12 alignment alignment NN cord-010092-uftc8inx 7083 13 with with IN cord-010092-uftc8inx 7083 14 previously previously RB cord-010092-uftc8inx 7083 15 published publish VBN cord-010092-uftc8inx 7083 16 data datum NNS cord-010092-uftc8inx 7083 17 . . . cord-010092-uftc8inx 7084 1 A a DT cord-010092-uftc8inx 7084 2 residual residual JJ cord-010092-uftc8inx 7084 3 amotosalen amotosalen VBN cord-010092-uftc8inx 7084 4 concentration concentration NN cord-010092-uftc8inx 7084 5 below below IN cord-010092-uftc8inx 7084 6 2 2 CD cord-010092-uftc8inx 7084 7 lM lM NNP cord-010092-uftc8inx 7084 8 is be VBZ cord-010092-uftc8inx 7084 9 considered consider VBN cord-010092-uftc8inx 7084 10 safe safe JJ cord-010092-uftc8inx 7084 11 and and CC cord-010092-uftc8inx 7084 12 acceptable acceptable JJ cord-010092-uftc8inx 7084 13 by by IN cord-010092-uftc8inx 7084 14 French french JJ cord-010092-uftc8inx 7084 15 and and CC cord-010092-uftc8inx 7084 16 German german JJ cord-010092-uftc8inx 7084 17 authorities authority NNS cord-010092-uftc8inx 7084 18 . . . cord-010092-uftc8inx 7085 1 The the DT cord-010092-uftc8inx 7085 2 evaluated evaluate VBN cord-010092-uftc8inx 7085 3 data data NN cord-010092-uftc8inx 7085 4 support support VBP cord-010092-uftc8inx 7085 5 the the DT cord-010092-uftc8inx 7085 6 reasonable reasonable JJ cord-010092-uftc8inx 7085 7 assurance assurance NN cord-010092-uftc8inx 7085 8 of of IN cord-010092-uftc8inx 7085 9 quality quality NN cord-010092-uftc8inx 7085 10 and and CC cord-010092-uftc8inx 7085 11 effectiveness effectiveness NN cord-010092-uftc8inx 7085 12 of of IN cord-010092-uftc8inx 7085 13 the the DT cord-010092-uftc8inx 7085 14 device device NN cord-010092-uftc8inx 7085 15 when when WRB cord-010092-uftc8inx 7085 16 used use VBN cord-010092-uftc8inx 7085 17 in in IN cord-010092-uftc8inx 7085 18 accordance accordance NN cord-010092-uftc8inx 7085 19 with with IN cord-010092-uftc8inx 7085 20 indication indication NN cord-010092-uftc8inx 7085 21 for for IN cord-010092-uftc8inx 7085 22 use use NN cord-010092-uftc8inx 7085 23 . . . cord-010092-uftc8inx 7086 1 Background background NN cord-010092-uftc8inx 7086 2 : : : cord-010092-uftc8inx 7087 1 The the DT cord-010092-uftc8inx 7087 2 implementation implementation NN cord-010092-uftc8inx 7087 3 of of IN cord-010092-uftc8inx 7087 4 a a DT cord-010092-uftc8inx 7087 5 pathogen pathogen NN cord-010092-uftc8inx 7087 6 inactivation inactivation NN cord-010092-uftc8inx 7087 7 process process NN cord-010092-uftc8inx 7087 8 ( ( -LRB- cord-010092-uftc8inx 7087 9 PI PI NNP cord-010092-uftc8inx 7087 10 ) ) -RRB- cord-010092-uftc8inx 7087 11 allows allow VBZ cord-010092-uftc8inx 7087 12 the the DT cord-010092-uftc8inx 7087 13 redesign redesign NN cord-010092-uftc8inx 7087 14 of of IN cord-010092-uftc8inx 7087 15 processes process NNS cord-010092-uftc8inx 7087 16 to to IN cord-010092-uftc8inx 7087 17 obtaining obtain VBG cord-010092-uftc8inx 7087 18 safe safe JJ cord-010092-uftc8inx 7087 19 blood blood NN cord-010092-uftc8inx 7087 20 components component NNS cord-010092-uftc8inx 7087 21 by by IN cord-010092-uftc8inx 7087 22 reducing reduce VBG cord-010092-uftc8inx 7087 23 the the DT cord-010092-uftc8inx 7087 24 need need NN cord-010092-uftc8inx 7087 25 for for IN cord-010092-uftc8inx 7087 26 additional additional JJ cord-010092-uftc8inx 7087 27 testing testing NN cord-010092-uftc8inx 7087 28 for for IN cord-010092-uftc8inx 7087 29 pathogens pathogen NNS cord-010092-uftc8inx 7087 30 detection detection NN cord-010092-uftc8inx 7087 31 , , , cord-010092-uftc8inx 7087 32 minimizing minimize VBG cord-010092-uftc8inx 7087 33 the the DT cord-010092-uftc8inx 7087 34 residual residual JJ cord-010092-uftc8inx 7087 35 risks risk NNS cord-010092-uftc8inx 7087 36 ( ( -LRB- cord-010092-uftc8inx 7087 37 such such JJ cord-010092-uftc8inx 7087 38 as as IN cord-010092-uftc8inx 7087 39 the the DT cord-010092-uftc8inx 7087 40 infectious infectious JJ cord-010092-uftc8inx 7087 41 window window NN cord-010092-uftc8inx 7087 42 period period NN cord-010092-uftc8inx 7087 43 for for IN cord-010092-uftc8inx 7087 44 those those DT cord-010092-uftc8inx 7087 45 pathogens pathogen NNS cord-010092-uftc8inx 7087 46 that that WDT cord-010092-uftc8inx 7087 47 are be VBP cord-010092-uftc8inx 7087 48 detected detect VBN cord-010092-uftc8inx 7087 49 as as IN cord-010092-uftc8inx 7087 50 usual usual JJ cord-010092-uftc8inx 7087 51 ) ) -RRB- cord-010092-uftc8inx 7087 52 , , , cord-010092-uftc8inx 7087 53 eliminates eliminate VBZ cord-010092-uftc8inx 7087 54 the the DT cord-010092-uftc8inx 7087 55 need need NN cord-010092-uftc8inx 7087 56 for for IN cord-010092-uftc8inx 7087 57 selective selective JJ cord-010092-uftc8inx 7087 58 tests test NNS cord-010092-uftc8inx 7087 59 ( ( -LRB- cord-010092-uftc8inx 7087 60 eg eg IN cord-010092-uftc8inx 7087 61 Cytomegalovirus Cytomegalovirus NNP cord-010092-uftc8inx 7087 62 serology serology NN cord-010092-uftc8inx 7087 63 test test NN cord-010092-uftc8inx 7087 64 ) ) -RRB- cord-010092-uftc8inx 7087 65 and and CC cord-010092-uftc8inx 7087 66 complements complement VBZ cord-010092-uftc8inx 7087 67 gamma gamma NN cord-010092-uftc8inx 7087 68 irradiation irradiation NN cord-010092-uftc8inx 7087 69 given give VBN cord-010092-uftc8inx 7087 70 its -PRON- PRP$ cord-010092-uftc8inx 7087 71 ability ability NN cord-010092-uftc8inx 7087 72 to to TO cord-010092-uftc8inx 7087 73 inactivate inactivate VB cord-010092-uftc8inx 7087 74 white white JJ cord-010092-uftc8inx 7087 75 blood blood NN cord-010092-uftc8inx 7087 76 cells cell NNS cord-010092-uftc8inx 7087 77 . . . cord-010092-uftc8inx 7088 1 In in IN cord-010092-uftc8inx 7088 2 addition addition NN cord-010092-uftc8inx 7088 3 , , , cord-010092-uftc8inx 7088 4 the the DT cord-010092-uftc8inx 7088 5 routine routine JJ cord-010092-uftc8inx 7088 6 implementation implementation NN cord-010092-uftc8inx 7088 7 of of IN cord-010092-uftc8inx 7088 8 PI PI NNP cord-010092-uftc8inx 7088 9 reduces reduce VBZ cord-010092-uftc8inx 7088 10 the the DT cord-010092-uftc8inx 7088 11 incidence incidence NN cord-010092-uftc8inx 7088 12 of of IN cord-010092-uftc8inx 7088 13 bacterial bacterial JJ cord-010092-uftc8inx 7088 14 infection infection NN cord-010092-uftc8inx 7088 15 in in IN cord-010092-uftc8inx 7088 16 recipients recipient NNS cord-010092-uftc8inx 7088 17 of of IN cord-010092-uftc8inx 7088 18 blood blood NN cord-010092-uftc8inx 7088 19 components component NNS cord-010092-uftc8inx 7088 20 and and CC cord-010092-uftc8inx 7088 21 allows allow VBZ cord-010092-uftc8inx 7088 22 blood blood NN cord-010092-uftc8inx 7088 23 services service NNS cord-010092-uftc8inx 7088 24 to to TO cord-010092-uftc8inx 7088 25 proactively proactively RB cord-010092-uftc8inx 7088 26 protect protect VB cord-010092-uftc8inx 7088 27 the the DT cord-010092-uftc8inx 7088 28 blood blood NN cord-010092-uftc8inx 7088 29 supply supply NN cord-010092-uftc8inx 7088 30 against against IN cord-010092-uftc8inx 7088 31 future future JJ cord-010092-uftc8inx 7088 32 emerging emerge VBG cord-010092-uftc8inx 7088 33 infections infection NNS cord-010092-uftc8inx 7088 34 . . . cord-010092-uftc8inx 7089 1 Aims aim VBZ cord-010092-uftc8inx 7089 2 : : : cord-010092-uftc8inx 7090 1 To to TO cord-010092-uftc8inx 7090 2 verify verify VB cord-010092-uftc8inx 7090 3 the the DT cord-010092-uftc8inx 7090 4 functional functional JJ cord-010092-uftc8inx 7090 5 integrity integrity NN cord-010092-uftc8inx 7090 6 and and CC cord-010092-uftc8inx 7090 7 viability viability NN cord-010092-uftc8inx 7090 8 of of IN cord-010092-uftc8inx 7090 9 platelet platelet NN cord-010092-uftc8inx 7090 10 concentrates concentrate VBZ cord-010092-uftc8inx 7090 11 after after IN cord-010092-uftc8inx 7090 12 being be VBG cord-010092-uftc8inx 7090 13 inactivated inactivate VBN cord-010092-uftc8inx 7090 14 of of IN cord-010092-uftc8inx 7090 15 any any DT cord-010092-uftc8inx 7090 16 pathogenic pathogenic JJ cord-010092-uftc8inx 7090 17 agent agent NN cord-010092-uftc8inx 7090 18 , , , cord-010092-uftc8inx 7090 19 to to TO cord-010092-uftc8inx 7090 20 be be VB cord-010092-uftc8inx 7090 21 used use VBN cord-010092-uftc8inx 7090 22 as as IN cord-010092-uftc8inx 7090 23 safe safe JJ cord-010092-uftc8inx 7090 24 and and CC cord-010092-uftc8inx 7090 25 functional functional JJ cord-010092-uftc8inx 7090 26 components component NNS cord-010092-uftc8inx 7090 27 for for IN cord-010092-uftc8inx 7090 28 transfusions transfusion NNS cord-010092-uftc8inx 7090 29 . . . cord-010092-uftc8inx 7091 1 Methods method NNS cord-010092-uftc8inx 7091 2 : : : cord-010092-uftc8inx 7091 3 A a DT cord-010092-uftc8inx 7091 4 total total NN cord-010092-uftc8inx 7091 5 of of IN cord-010092-uftc8inx 7091 6 106 106 CD cord-010092-uftc8inx 7091 7 independent independent JJ cord-010092-uftc8inx 7091 8 platelet platelet NN cord-010092-uftc8inx 7091 9 concentrates concentrate NNS cord-010092-uftc8inx 7091 10 were be VBD cord-010092-uftc8inx 7091 11 studied study VBN cord-010092-uftc8inx 7091 12 . . . cord-010092-uftc8inx 7092 1 Platelets platelet NNS cord-010092-uftc8inx 7092 2 are be VBP cord-010092-uftc8inx 7092 3 donated donate VBN cord-010092-uftc8inx 7092 4 through through IN cord-010092-uftc8inx 7092 5 a a DT cord-010092-uftc8inx 7092 6 process process NN cord-010092-uftc8inx 7092 7 called call VBN cord-010092-uftc8inx 7092 8 plateletpheresis plateletpheresis NN cord-010092-uftc8inx 7092 9 according accord VBG cord-010092-uftc8inx 7092 10 to to IN cord-010092-uftc8inx 7092 11 the the DT cord-010092-uftc8inx 7092 12 established establish VBN cord-010092-uftc8inx 7092 13 norms norm NNS cord-010092-uftc8inx 7092 14 , , , cord-010092-uftc8inx 7092 15 after after IN cord-010092-uftc8inx 7092 16 the the DT cord-010092-uftc8inx 7092 17 process process NN cord-010092-uftc8inx 7092 18 , , , cord-010092-uftc8inx 7092 19 platelet platelet NN cord-010092-uftc8inx 7092 20 concentrates concentrate NNS cord-010092-uftc8inx 7092 21 were be VBD cord-010092-uftc8inx 7092 22 submitted submit VBN cord-010092-uftc8inx 7092 23 to to IN cord-010092-uftc8inx 7092 24 PI PI NNP cord-010092-uftc8inx 7092 25 on on IN cord-010092-uftc8inx 7092 26 the the DT cord-010092-uftc8inx 7092 27 Intercept Intercept NNP cord-010092-uftc8inx 7092 28 Blood Blood NNP cord-010092-uftc8inx 7092 29 System System NNP cord-010092-uftc8inx 7092 30 TM TM NNP cord-010092-uftc8inx 7092 31 platform platform NN cord-010092-uftc8inx 7092 32 with with IN cord-010092-uftc8inx 7092 33 UV uv NN cord-010092-uftc8inx 7092 34 - - HYPH cord-010092-uftc8inx 7092 35 A a NN cord-010092-uftc8inx 7092 36 Illuminator illuminator NN cord-010092-uftc8inx 7092 37 ; ; : cord-010092-uftc8inx 7092 38 an an DT cord-010092-uftc8inx 7092 39 immediate immediate JJ cord-010092-uftc8inx 7092 40 sampling sampling NN cord-010092-uftc8inx 7092 41 of of IN cord-010092-uftc8inx 7092 42 each each DT cord-010092-uftc8inx 7092 43 donation donation NN cord-010092-uftc8inx 7092 44 of of IN cord-010092-uftc8inx 7092 45 platelet platelet NN cord-010092-uftc8inx 7092 46 concentrates concentrate NNS cord-010092-uftc8inx 7092 47 was be VBD cord-010092-uftc8inx 7092 48 carried carry VBN cord-010092-uftc8inx 7092 49 out out RP cord-010092-uftc8inx 7092 50 taking take VBG cord-010092-uftc8inx 7092 51 a a DT cord-010092-uftc8inx 7092 52 sample sample NN cord-010092-uftc8inx 7092 53 of of IN cord-010092-uftc8inx 7092 54 2 2 CD cord-010092-uftc8inx 7092 55 mL ml NN cord-010092-uftc8inx 7092 56 pre pre NN cord-010092-uftc8inx 7092 57 - - NN cord-010092-uftc8inx 7092 58 inactivation inactivation JJ cord-010092-uftc8inx 7092 59 and and CC cord-010092-uftc8inx 7092 60 another another DT cord-010092-uftc8inx 7092 61 sample sample NN cord-010092-uftc8inx 7092 62 post post NN cord-010092-uftc8inx 7092 63 - - JJ cord-010092-uftc8inx 7092 64 inactivation inactivation JJ cord-010092-uftc8inx 7092 65 ( ( -LRB- cord-010092-uftc8inx 7092 66 16 16 CD cord-010092-uftc8inx 7092 67 h h NN cord-010092-uftc8inx 7092 68 after after IN cord-010092-uftc8inx 7092 69 PI PI NNP cord-010092-uftc8inx 7092 70 ) ) -RRB- cord-010092-uftc8inx 7092 71 . . . cord-010092-uftc8inx 7093 1 The the DT cord-010092-uftc8inx 7093 2 platelet platelet NN cord-010092-uftc8inx 7093 3 viability viability NN cord-010092-uftc8inx 7093 4 of of IN cord-010092-uftc8inx 7093 5 each each DT cord-010092-uftc8inx 7093 6 sample sample NN cord-010092-uftc8inx 7093 7 was be VBD cord-010092-uftc8inx 7093 8 evaluated evaluate VBN cord-010092-uftc8inx 7093 9 by by IN cord-010092-uftc8inx 7093 10 demonstrating demonstrate VBG cord-010092-uftc8inx 7093 11 the the DT cord-010092-uftc8inx 7093 12 CD62P cd62p NN cord-010092-uftc8inx 7093 13 expression expression NN cord-010092-uftc8inx 7093 14 marker marker NN cord-010092-uftc8inx 7093 15 by by IN cord-010092-uftc8inx 7093 16 flow flow NN cord-010092-uftc8inx 7093 17 cytometry cytometry NN cord-010092-uftc8inx 7093 18 . . . cord-010092-uftc8inx 7094 1 Once once RB cord-010092-uftc8inx 7094 2 processed process VBN cord-010092-uftc8inx 7094 3 , , , cord-010092-uftc8inx 7094 4 platelet platelet NN cord-010092-uftc8inx 7094 5 concentrates concentrate NNS cord-010092-uftc8inx 7094 6 were be VBD cord-010092-uftc8inx 7094 7 released release VBN cord-010092-uftc8inx 7094 8 as as IN cord-010092-uftc8inx 7094 9 safe safe JJ cord-010092-uftc8inx 7094 10 components component NNS cord-010092-uftc8inx 7094 11 for for IN cord-010092-uftc8inx 7094 12 donation donation NN cord-010092-uftc8inx 7094 13 . . . cord-010092-uftc8inx 7095 1 Compiled compile VBN cord-010092-uftc8inx 7095 2 the the DT cord-010092-uftc8inx 7095 3 experimental experimental JJ cord-010092-uftc8inx 7095 4 data datum NNS cord-010092-uftc8inx 7095 5 of of IN cord-010092-uftc8inx 7095 6 the the DT cord-010092-uftc8inx 7095 7 platelet platelet NN cord-010092-uftc8inx 7095 8 count count NN cord-010092-uftc8inx 7095 9 with with IN cord-010092-uftc8inx 7095 10 platelet platelet NN cord-010092-uftc8inx 7095 11 activation activation NN cord-010092-uftc8inx 7095 12 marker marker NN cord-010092-uftc8inx 7095 13 with with IN cord-010092-uftc8inx 7095 14 respect respect NN cord-010092-uftc8inx 7095 15 to to IN cord-010092-uftc8inx 7095 16 the the DT cord-010092-uftc8inx 7095 17 total total JJ cord-010092-uftc8inx 7095 18 platelet platelet NN cord-010092-uftc8inx 7095 19 , , , cord-010092-uftc8inx 7095 20 a a DT cord-010092-uftc8inx 7095 21 comparative comparative JJ cord-010092-uftc8inx 7095 22 , , , cord-010092-uftc8inx 7095 23 nonparametric nonparametric JJ cord-010092-uftc8inx 7095 24 test test NN cord-010092-uftc8inx 7095 25 of of IN cord-010092-uftc8inx 7095 26 Wilcoxon Wilcoxon NNP cord-010092-uftc8inx 7095 27 was be VBD cord-010092-uftc8inx 7095 28 carried carry VBN cord-010092-uftc8inx 7095 29 out out RP cord-010092-uftc8inx 7095 30 between between IN cord-010092-uftc8inx 7095 31 two two CD cord-010092-uftc8inx 7095 32 measurements measurement NNS cord-010092-uftc8inx 7095 33 ( ( -LRB- cord-010092-uftc8inx 7095 34 pre pre VB cord-010092-uftc8inx 7095 35 vs vs IN cord-010092-uftc8inx 7095 36 post post NNP cord-010092-uftc8inx 7095 37 ) ) -RRB- cord-010092-uftc8inx 7095 38 and and CC cord-010092-uftc8inx 7095 39 the the DT cord-010092-uftc8inx 7095 40 platelet platelet NN cord-010092-uftc8inx 7095 41 viability viability NN cord-010092-uftc8inx 7095 42 after after IN cord-010092-uftc8inx 7095 43 PI PI NNP cord-010092-uftc8inx 7095 44 was be VBD cord-010092-uftc8inx 7095 45 determined determine VBN cord-010092-uftc8inx 7095 46 . . . cord-010092-uftc8inx 7096 1 Results result NNS cord-010092-uftc8inx 7096 2 : : : cord-010092-uftc8inx 7097 1 A a DT cord-010092-uftc8inx 7097 2 total total NN cord-010092-uftc8inx 7097 3 of of IN cord-010092-uftc8inx 7097 4 106 106 CD cord-010092-uftc8inx 7097 5 independent independent JJ cord-010092-uftc8inx 7097 6 platelet platelet NN cord-010092-uftc8inx 7097 7 concentrates concentrate NNS cord-010092-uftc8inx 7097 8 were be VBD cord-010092-uftc8inx 7097 9 studied study VBN cord-010092-uftc8inx 7097 10 , , , cord-010092-uftc8inx 7097 11 where where WRB cord-010092-uftc8inx 7097 12 the the DT cord-010092-uftc8inx 7097 13 average average JJ cord-010092-uftc8inx 7097 14 percentage percentage NN cord-010092-uftc8inx 7097 15 of of IN cord-010092-uftc8inx 7097 16 pre pre JJ cord-010092-uftc8inx 7097 17 - - JJ cord-010092-uftc8inx 7097 18 inactivated inactivated JJ cord-010092-uftc8inx 7097 19 platelets platelet NNS cord-010092-uftc8inx 7097 20 with with IN cord-010092-uftc8inx 7097 21 expression expression NN cord-010092-uftc8inx 7097 22 of of IN cord-010092-uftc8inx 7097 23 the the DT cord-010092-uftc8inx 7097 24 CD62P CD62P NNP cord-010092-uftc8inx 7097 25 marker marker NN cord-010092-uftc8inx 7097 26 , , , cord-010092-uftc8inx 7097 27 was be VBD cord-010092-uftc8inx 7097 28 18 18 CD cord-010092-uftc8inx 7097 29 % % NN cord-010092-uftc8inx 7097 30 , , , cord-010092-uftc8inx 7097 31 while while IN cord-010092-uftc8inx 7097 32 the the DT cord-010092-uftc8inx 7097 33 percentage percentage NN cord-010092-uftc8inx 7097 34 of of IN cord-010092-uftc8inx 7097 35 functional functional JJ cord-010092-uftc8inx 7097 36 platelets platelet NNS cord-010092-uftc8inx 7097 37 post post NN cord-010092-uftc8inx 7097 38 inactivation inactivation NN cord-010092-uftc8inx 7097 39 was be VBD cord-010092-uftc8inx 7097 40 19 19 CD cord-010092-uftc8inx 7097 41 % % NN cord-010092-uftc8inx 7097 42 , , , cord-010092-uftc8inx 7097 43 this this DT cord-010092-uftc8inx 7097 44 result result NN cord-010092-uftc8inx 7097 45 only only RB cord-010092-uftc8inx 7097 46 shows show VBZ cord-010092-uftc8inx 7097 47 that that IN cord-010092-uftc8inx 7097 48 the the DT cord-010092-uftc8inx 7097 49 functionality functionality NN cord-010092-uftc8inx 7097 50 of of IN cord-010092-uftc8inx 7097 51 the the DT cord-010092-uftc8inx 7097 52 platelets platelet NNS cord-010092-uftc8inx 7097 53 is be VBZ cord-010092-uftc8inx 7097 54 not not RB cord-010092-uftc8inx 7097 55 being be VBG cord-010092-uftc8inx 7097 56 altered alter VBN cord-010092-uftc8inx 7097 57 after after IN cord-010092-uftc8inx 7097 58 the the DT cord-010092-uftc8inx 7097 59 inactivation inactivation NN cord-010092-uftc8inx 7097 60 process process NN cord-010092-uftc8inx 7097 61 . . . cord-010092-uftc8inx 7098 1 The the DT cord-010092-uftc8inx 7098 2 Wilcoxon Wilcoxon NNP cord-010092-uftc8inx 7098 3 test test NN cord-010092-uftc8inx 7098 4 confirms confirm VBZ cord-010092-uftc8inx 7098 5 that that IN cord-010092-uftc8inx 7098 6 there there EX cord-010092-uftc8inx 7098 7 is be VBZ cord-010092-uftc8inx 7098 8 no no DT cord-010092-uftc8inx 7098 9 significant significant JJ cord-010092-uftc8inx 7098 10 difference difference NN cord-010092-uftc8inx 7098 11 between between IN cord-010092-uftc8inx 7098 12 platelet platelet NN cord-010092-uftc8inx 7098 13 activity activity NN cord-010092-uftc8inx 7098 14 pre pre VBN cord-010092-uftc8inx 7098 15 - - JJ cord-010092-uftc8inx 7098 16 and and CC cord-010092-uftc8inx 7098 17 post post NN cord-010092-uftc8inx 7098 18 - - NN cord-010092-uftc8inx 7098 19 inactivation inactivation JJ cord-010092-uftc8inx 7098 20 , , , cord-010092-uftc8inx 7098 21 with with IN cord-010092-uftc8inx 7098 22 a a DT cord-010092-uftc8inx 7098 23 95 95 CD cord-010092-uftc8inx 7098 24 % % NN cord-010092-uftc8inx 7098 25 confidence confidence NN cord-010092-uftc8inx 7098 26 level level NN cord-010092-uftc8inx 7098 27 . . . cord-010092-uftc8inx 7099 1 Summary Summary NNP cord-010092-uftc8inx 7099 2 / / SYM cord-010092-uftc8inx 7099 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 7099 4 : : : cord-010092-uftc8inx 7100 1 The the DT cord-010092-uftc8inx 7100 2 process process NN cord-010092-uftc8inx 7100 3 of of IN cord-010092-uftc8inx 7100 4 photochemical photochemical JJ cord-010092-uftc8inx 7100 5 treatment treatment NN cord-010092-uftc8inx 7100 6 with with IN cord-010092-uftc8inx 7100 7 amotosalen amotosalen VBN cord-010092-uftc8inx 7100 8 hydrochloride hydrochloride NN cord-010092-uftc8inx 7100 9 and and CC cord-010092-uftc8inx 7100 10 long long JJ cord-010092-uftc8inx 7100 11 - - HYPH cord-010092-uftc8inx 7100 12 wavelength wavelength NN cord-010092-uftc8inx 7100 13 ultraviolet ultraviolet NN cord-010092-uftc8inx 7100 14 light light NN cord-010092-uftc8inx 7100 15 ( ( -LRB- cord-010092-uftc8inx 7100 16 UVA UVA NNP cord-010092-uftc8inx 7100 17 ) ) -RRB- cord-010092-uftc8inx 7100 18 applied apply VBD cord-010092-uftc8inx 7100 19 to to IN cord-010092-uftc8inx 7100 20 platelet platelet NN cord-010092-uftc8inx 7100 21 concentrates concentrate NNS cord-010092-uftc8inx 7100 22 provides provide VBZ cord-010092-uftc8inx 7100 23 functional functional JJ cord-010092-uftc8inx 7100 24 products product NNS cord-010092-uftc8inx 7100 25 without without IN cord-010092-uftc8inx 7100 26 alterations alteration NNS cord-010092-uftc8inx 7100 27 in in IN cord-010092-uftc8inx 7100 28 platelet platelet NN cord-010092-uftc8inx 7100 29 function function NN cord-010092-uftc8inx 7100 30 to to TO cord-010092-uftc8inx 7100 31 be be VB cord-010092-uftc8inx 7100 32 transfused transfuse VBN cord-010092-uftc8inx 7100 33 . . . cord-010092-uftc8inx 7101 1 Background background NN cord-010092-uftc8inx 7101 2 : : : cord-010092-uftc8inx 7102 1 Treatment treatment NN cord-010092-uftc8inx 7102 2 of of IN cord-010092-uftc8inx 7102 3 platelet platelet NN cord-010092-uftc8inx 7102 4 concentrates concentrate NNS cord-010092-uftc8inx 7102 5 ( ( -LRB- cord-010092-uftc8inx 7102 6 PCs pc NNS cord-010092-uftc8inx 7102 7 ) ) -RRB- cord-010092-uftc8inx 7102 8 with with IN cord-010092-uftc8inx 7102 9 pathogen pathogen NN cord-010092-uftc8inx 7102 10 reduction reduction NN cord-010092-uftc8inx 7102 11 technologies technology NNS cord-010092-uftc8inx 7102 12 is be VBZ cord-010092-uftc8inx 7102 13 widely widely RB cord-010092-uftc8inx 7102 14 implemented implement VBN cord-010092-uftc8inx 7102 15 in in IN cord-010092-uftc8inx 7102 16 blood blood NN cord-010092-uftc8inx 7102 17 establishments establishment NNS cord-010092-uftc8inx 7102 18 to to TO cord-010092-uftc8inx 7102 19 reduce reduce VB cord-010092-uftc8inx 7102 20 the the DT cord-010092-uftc8inx 7102 21 risk risk NN cord-010092-uftc8inx 7102 22 of of IN cord-010092-uftc8inx 7102 23 bacterial bacterial JJ cord-010092-uftc8inx 7102 24 contamination contamination NN cord-010092-uftc8inx 7102 25 and and CC cord-010092-uftc8inx 7102 26 to to TO cord-010092-uftc8inx 7102 27 face face VB cord-010092-uftc8inx 7102 28 the the DT cord-010092-uftc8inx 7102 29 presence presence NN cord-010092-uftc8inx 7102 30 of of IN cord-010092-uftc8inx 7102 31 new new JJ cord-010092-uftc8inx 7102 32 emerging emerge VBG cord-010092-uftc8inx 7102 33 agents agent NNS cord-010092-uftc8inx 7102 34 in in IN cord-010092-uftc8inx 7102 35 blood blood NN cord-010092-uftc8inx 7102 36 components component NNS cord-010092-uftc8inx 7102 37 . . . cord-010092-uftc8inx 7103 1 Aims aim VBZ cord-010092-uftc8inx 7103 2 : : : cord-010092-uftc8inx 7104 1 The the DT cord-010092-uftc8inx 7104 2 reduction reduction NN cord-010092-uftc8inx 7104 3 of of IN cord-010092-uftc8inx 7104 4 antioxidant antioxidant JJ cord-010092-uftc8inx 7104 5 power power NN cord-010092-uftc8inx 7104 6 ( ( -LRB- cord-010092-uftc8inx 7104 7 AOP AOP NNP cord-010092-uftc8inx 7104 8 ) ) -RRB- cord-010092-uftc8inx 7104 9 could could MD cord-010092-uftc8inx 7104 10 be be VB cord-010092-uftc8inx 7104 11 a a DT cord-010092-uftc8inx 7104 12 quality quality NN cord-010092-uftc8inx 7104 13 control control NN cord-010092-uftc8inx 7104 14 test test NN cord-010092-uftc8inx 7104 15 to to TO cord-010092-uftc8inx 7104 16 prove prove VB cord-010092-uftc8inx 7104 17 the the DT cord-010092-uftc8inx 7104 18 complete complete JJ cord-010092-uftc8inx 7104 19 viro viro NN cord-010092-uftc8inx 7104 20 - - HYPH cord-010092-uftc8inx 7104 21 inactivation inactivation NN cord-010092-uftc8inx 7104 22 treatment treatment NN cord-010092-uftc8inx 7104 23 . . . cord-010092-uftc8inx 7105 1 This this DT cord-010092-uftc8inx 7105 2 evaluation evaluation NN cord-010092-uftc8inx 7105 3 has have VBZ cord-010092-uftc8inx 7105 4 the the DT cord-010092-uftc8inx 7105 5 goal goal NN cord-010092-uftc8inx 7105 6 to to TO cord-010092-uftc8inx 7105 7 study study VB cord-010092-uftc8inx 7105 8 the the DT cord-010092-uftc8inx 7105 9 feasibility feasibility NN cord-010092-uftc8inx 7105 10 of of IN cord-010092-uftc8inx 7105 11 the the DT cord-010092-uftc8inx 7105 12 method method NN cord-010092-uftc8inx 7105 13 from from IN cord-010092-uftc8inx 7105 14 " " `` cord-010092-uftc8inx 7105 15 Abonnenc Abonnenc NNP cord-010092-uftc8inx 7105 16 et et NNP cord-010092-uftc8inx 7105 17 al al NNP cord-010092-uftc8inx 7105 18 . . . cord-010092-uftc8inx 7106 1 , , , cord-010092-uftc8inx 7106 2 Transfusion transfusion NN cord-010092-uftc8inx 7106 3 , , , cord-010092-uftc8inx 7106 4 2016 2016 CD cord-010092-uftc8inx 7106 5 " " '' cord-010092-uftc8inx 7106 6 in in IN cord-010092-uftc8inx 7106 7 another another DT cord-010092-uftc8inx 7106 8 blood blood NN cord-010092-uftc8inx 7106 9 service service NN cord-010092-uftc8inx 7106 10 , , , cord-010092-uftc8inx 7106 11 assessing assess VBG cord-010092-uftc8inx 7106 12 the the DT cord-010092-uftc8inx 7106 13 AOP aop NN cord-010092-uftc8inx 7106 14 of of IN cord-010092-uftc8inx 7106 15 platelet platelet NN cord-010092-uftc8inx 7106 16 units unit NNS cord-010092-uftc8inx 7106 17 treated treat VBN cord-010092-uftc8inx 7106 18 by by IN cord-010092-uftc8inx 7106 19 INTERCEPT INTERCEPT NNP cord-010092-uftc8inx 7106 20 technology technology NN cord-010092-uftc8inx 7106 21 . . . cord-010092-uftc8inx 7107 1 Methods method NNS cord-010092-uftc8inx 7107 2 : : : cord-010092-uftc8inx 7108 1 The the DT cord-010092-uftc8inx 7108 2 AOP AOP NNP cord-010092-uftc8inx 7108 3 is be VBZ cord-010092-uftc8inx 7108 4 expressed express VBN cord-010092-uftc8inx 7108 5 in in IN cord-010092-uftc8inx 7108 6 EDEL EDEL NNP cord-010092-uftc8inx 7108 7 value value NN cord-010092-uftc8inx 7108 8 , , , cord-010092-uftc8inx 7108 9 one one CD cord-010092-uftc8inx 7108 10 EDEL EDEL NNP cord-010092-uftc8inx 7108 11 being be VBG cord-010092-uftc8inx 7108 12 equivalent equivalent JJ cord-010092-uftc8inx 7108 13 to to IN cord-010092-uftc8inx 7108 14 1 1 CD cord-010092-uftc8inx 7108 15 lmol lmol NNP cord-010092-uftc8inx 7108 16 / / SYM cord-010092-uftc8inx 7108 17 L l NN cord-010092-uftc8inx 7108 18 ascorbic ascorbic NN cord-010092-uftc8inx 7108 19 acid acid NN cord-010092-uftc8inx 7108 20 . . . cord-010092-uftc8inx 7109 1 Repeatability repeatability NN cord-010092-uftc8inx 7109 2 , , , cord-010092-uftc8inx 7109 3 intermediate intermediate JJ cord-010092-uftc8inx 7109 4 precision precision NN cord-010092-uftc8inx 7109 5 and and CC cord-010092-uftc8inx 7109 6 accuracy accuracy NN cord-010092-uftc8inx 7109 7 were be VBD cord-010092-uftc8inx 7109 8 determined determine VBN cord-010092-uftc8inx 7109 9 . . . cord-010092-uftc8inx 7110 1 Linearity linearity NN cord-010092-uftc8inx 7110 2 was be VBD cord-010092-uftc8inx 7110 3 evaluated evaluate VBN cord-010092-uftc8inx 7110 4 using use VBG cord-010092-uftc8inx 7110 5 the the DT cord-010092-uftc8inx 7110 6 linear linear JJ cord-010092-uftc8inx 7110 7 regression regression NN cord-010092-uftc8inx 7110 8 and and CC cord-010092-uftc8inx 7110 9 the the DT cord-010092-uftc8inx 7110 10 calculation calculation NN cord-010092-uftc8inx 7110 11 of of IN cord-010092-uftc8inx 7110 12 Pearson Pearson NNP cord-010092-uftc8inx 7110 13 's 's POS cord-010092-uftc8inx 7110 14 coefficient coefficient NN cord-010092-uftc8inx 7110 15 ( ( -LRB- cord-010092-uftc8inx 7110 16 R² R² NNP cord-010092-uftc8inx 7110 17 ) ) -RRB- cord-010092-uftc8inx 7110 18 . . . cord-010092-uftc8inx 7111 1 Limit limit NN cord-010092-uftc8inx 7111 2 of of IN cord-010092-uftc8inx 7111 3 quantification quantification NN cord-010092-uftc8inx 7111 4 ( ( -LRB- cord-010092-uftc8inx 7111 5 LOQ LOQ NNP cord-010092-uftc8inx 7111 6 ) ) -RRB- cord-010092-uftc8inx 7111 7 was be VBD cord-010092-uftc8inx 7111 8 determined determine VBN cord-010092-uftc8inx 7111 9 by by IN cord-010092-uftc8inx 7111 10 measuring measure VBG cord-010092-uftc8inx 7111 11 AOP aop NN cord-010092-uftc8inx 7111 12 using use VBG cord-010092-uftc8inx 7111 13 NaCl nacl NN cord-010092-uftc8inx 7111 14 samples sample NNS cord-010092-uftc8inx 7111 15 to to TO cord-010092-uftc8inx 7111 16 define define VB cord-010092-uftc8inx 7111 17 the the DT cord-010092-uftc8inx 7111 18 background background NN cord-010092-uftc8inx 7111 19 . . . cord-010092-uftc8inx 7112 1 ROC ROC NNP cord-010092-uftc8inx 7112 2 curves curve NNS cord-010092-uftc8inx 7112 3 were be VBD cord-010092-uftc8inx 7112 4 used use VBN cord-010092-uftc8inx 7112 5 to to TO cord-010092-uftc8inx 7112 6 determine determine VB cord-010092-uftc8inx 7112 7 a a DT cord-010092-uftc8inx 7112 8 threshold threshold NN cord-010092-uftc8inx 7112 9 to to TO cord-010092-uftc8inx 7112 10 discriminate discriminate VB cord-010092-uftc8inx 7112 11 PCs pc NNS cord-010092-uftc8inx 7112 12 before before IN cord-010092-uftc8inx 7112 13 and and CC cord-010092-uftc8inx 7112 14 after after IN cord-010092-uftc8inx 7112 15 treatment treatment NN cord-010092-uftc8inx 7112 16 . . . cord-010092-uftc8inx 7113 1 A a DT cord-010092-uftc8inx 7113 2 distinction distinction NN cord-010092-uftc8inx 7113 3 was be VBD cord-010092-uftc8inx 7113 4 realized realize VBN cord-010092-uftc8inx 7113 5 between between IN cord-010092-uftc8inx 7113 6 men man NNS cord-010092-uftc8inx 7113 7 and and CC cord-010092-uftc8inx 7113 8 women woman NNS cord-010092-uftc8inx 7113 9 and and CC cord-010092-uftc8inx 7113 10 between between IN cord-010092-uftc8inx 7113 11 apheresis apheresis NN cord-010092-uftc8inx 7113 12 ( ( -LRB- cord-010092-uftc8inx 7113 13 A A NNP cord-010092-uftc8inx 7113 14 ) ) -RRB- cord-010092-uftc8inx 7113 15 PC pc NN cord-010092-uftc8inx 7113 16 and and CC cord-010092-uftc8inx 7113 17 buffy buffy NNP cord-010092-uftc8inx 7113 18 coats coat NNS cord-010092-uftc8inx 7113 19 ( ( -LRB- cord-010092-uftc8inx 7113 20 BC BC NNP cord-010092-uftc8inx 7113 21 ) ) -RRB- cord-010092-uftc8inx 7113 22 PCs pc NNS cord-010092-uftc8inx 7113 23 . . . cord-010092-uftc8inx 7114 1 A a DT cord-010092-uftc8inx 7114 2 one one CD cord-010092-uftc8inx 7114 3 - - HYPH cord-010092-uftc8inx 7114 4 year year NN cord-010092-uftc8inx 7114 5 evaluation evaluation NN cord-010092-uftc8inx 7114 6 was be VBD cord-010092-uftc8inx 7114 7 assessed assess VBN cord-010092-uftc8inx 7114 8 on on IN cord-010092-uftc8inx 7114 9 PCs pc NNS cord-010092-uftc8inx 7114 10 before before IN cord-010092-uftc8inx 7114 11 and and CC cord-010092-uftc8inx 7114 12 after after IN cord-010092-uftc8inx 7114 13 treatment treatment NN cord-010092-uftc8inx 7114 14 on on IN cord-010092-uftc8inx 7114 15 the the DT cord-010092-uftc8inx 7114 16 routine routine JJ cord-010092-uftc8inx 7114 17 production production NN cord-010092-uftc8inx 7114 18 . . . cord-010092-uftc8inx 7115 1 Results result NNS cord-010092-uftc8inx 7115 2 : : : cord-010092-uftc8inx 7116 1 The the DT cord-010092-uftc8inx 7116 2 coefficient coefficient NN cord-010092-uftc8inx 7116 3 of of IN cord-010092-uftc8inx 7116 4 variation variation NN cord-010092-uftc8inx 7116 5 for for IN cord-010092-uftc8inx 7116 6 the the DT cord-010092-uftc8inx 7116 7 repeatability repeatability NN cord-010092-uftc8inx 7116 8 was be VBD cord-010092-uftc8inx 7116 9 less less JJR cord-010092-uftc8inx 7116 10 than than IN cord-010092-uftc8inx 7116 11 10 10 CD cord-010092-uftc8inx 7116 12 % % NN cord-010092-uftc8inx 7116 13 . . . cord-010092-uftc8inx 7117 1 For for IN cord-010092-uftc8inx 7117 2 the the DT cord-010092-uftc8inx 7117 3 intermediate intermediate JJ cord-010092-uftc8inx 7117 4 precision precision NN cord-010092-uftc8inx 7117 5 , , , cord-010092-uftc8inx 7117 6 the the DT cord-010092-uftc8inx 7117 7 coefficient coefficient NN cord-010092-uftc8inx 7117 8 of of IN cord-010092-uftc8inx 7117 9 variation variation NN cord-010092-uftc8inx 7117 10 was be VBD cord-010092-uftc8inx 7117 11 less less JJR cord-010092-uftc8inx 7117 12 than than IN cord-010092-uftc8inx 7117 13 15 15 CD cord-010092-uftc8inx 7117 14 % % NN cord-010092-uftc8inx 7117 15 , , , cord-010092-uftc8inx 7117 16 but but CC cord-010092-uftc8inx 7117 17 for for IN cord-010092-uftc8inx 7117 18 the the DT cord-010092-uftc8inx 7117 19 PCs pc NNS cord-010092-uftc8inx 7117 20 after after IN cord-010092-uftc8inx 7117 21 treatment treatment NN cord-010092-uftc8inx 7117 22 , , , cord-010092-uftc8inx 7117 23 this this DT cord-010092-uftc8inx 7117 24 result result NN cord-010092-uftc8inx 7117 25 rose rise VBD cord-010092-uftc8inx 7117 26 up up RP cord-010092-uftc8inx 7117 27 to to TO cord-010092-uftc8inx 7117 28 21 21 CD cord-010092-uftc8inx 7117 29 % % NN cord-010092-uftc8inx 7117 30 . . . cord-010092-uftc8inx 7118 1 The the DT cord-010092-uftc8inx 7118 2 R² r² NN cord-010092-uftc8inx 7118 3 value value NN cord-010092-uftc8inx 7118 4 for for IN cord-010092-uftc8inx 7118 5 the the DT cord-010092-uftc8inx 7118 6 linearity linearity NN cord-010092-uftc8inx 7118 7 was be VBD cord-010092-uftc8inx 7118 8 97.7 97.7 CD cord-010092-uftc8inx 7118 9 % % NN cord-010092-uftc8inx 7118 10 . . . cord-010092-uftc8inx 7119 1 The the DT cord-010092-uftc8inx 7119 2 detection detection NN cord-010092-uftc8inx 7119 3 limit limit NN cord-010092-uftc8inx 7119 4 corresponded correspond VBD cord-010092-uftc8inx 7119 5 to to IN cord-010092-uftc8inx 7119 6 a a DT cord-010092-uftc8inx 7119 7 result result NN cord-010092-uftc8inx 7119 8 of of IN cord-010092-uftc8inx 7119 9 6 6 CD cord-010092-uftc8inx 7119 10 EDEL EDEL NNP cord-010092-uftc8inx 7119 11 and and CC cord-010092-uftc8inx 7119 12 the the DT cord-010092-uftc8inx 7119 13 LOQ LOQ NNP cord-010092-uftc8inx 7119 14 ( ( -LRB- cord-010092-uftc8inx 7119 15 equal equal JJ cord-010092-uftc8inx 7119 16 to to IN cord-010092-uftc8inx 7119 17 10xSD 10xsd CD cord-010092-uftc8inx 7119 18 ) ) -RRB- cord-010092-uftc8inx 7119 19 is be VBZ cord-010092-uftc8inx 7119 20 19 19 CD cord-010092-uftc8inx 7119 21 EDEL EDEL NNP cord-010092-uftc8inx 7119 22 . . . cord-010092-uftc8inx 7120 1 Concerning concern VBG cord-010092-uftc8inx 7120 2 ROC ROC NNP cord-010092-uftc8inx 7120 3 curves curve NNS cord-010092-uftc8inx 7120 4 , , , cord-010092-uftc8inx 7120 5 the the DT cord-010092-uftc8inx 7120 6 men man NNS cord-010092-uftc8inx 7120 7 APCs apc NNS cord-010092-uftc8inx 7120 8 threshold threshold NN cord-010092-uftc8inx 7120 9 was be VBD cord-010092-uftc8inx 7120 10 58.5 58.5 CD cord-010092-uftc8inx 7120 11 EDEL EDEL NNP cord-010092-uftc8inx 7120 12 compared compare VBN cord-010092-uftc8inx 7120 13 to to IN cord-010092-uftc8inx 7120 14 women woman NNS cord-010092-uftc8inx 7120 15 APCs apc NNS cord-010092-uftc8inx 7120 16 with with IN cord-010092-uftc8inx 7120 17 62.5 62.5 CD cord-010092-uftc8inx 7120 18 EDEL EDEL NNP cord-010092-uftc8inx 7120 19 . . . cord-010092-uftc8inx 7121 1 The the DT cord-010092-uftc8inx 7121 2 threshold threshold NN cord-010092-uftc8inx 7121 3 for for IN cord-010092-uftc8inx 7121 4 BCPC BCPC NNP cord-010092-uftc8inx 7121 5 was be VBD cord-010092-uftc8inx 7121 6 54 54 CD cord-010092-uftc8inx 7121 7 EDEL EDEL NNS cord-010092-uftc8inx 7121 8 . . . cord-010092-uftc8inx 7122 1 All all DT cord-010092-uftc8inx 7122 2 of of IN cord-010092-uftc8inx 7122 3 these these DT cord-010092-uftc8inx 7122 4 results result NNS cord-010092-uftc8inx 7122 5 had have VBD cord-010092-uftc8inx 7122 6 100 100 CD cord-010092-uftc8inx 7122 7 % % NN cord-010092-uftc8inx 7122 8 of of IN cord-010092-uftc8inx 7122 9 specificity specificity NN cord-010092-uftc8inx 7122 10 . . . cord-010092-uftc8inx 7123 1 Below below IN cord-010092-uftc8inx 7123 2 this this DT cord-010092-uftc8inx 7123 3 threshold threshold NN cord-010092-uftc8inx 7123 4 , , , cord-010092-uftc8inx 7123 5 INTERCEPT INTERCEPT NNP cord-010092-uftc8inx 7123 6 treatment treatment NN cord-010092-uftc8inx 7123 7 was be VBD cord-010092-uftc8inx 7123 8 considered consider VBN cord-010092-uftc8inx 7123 9 to to TO cord-010092-uftc8inx 7123 10 be be VB cord-010092-uftc8inx 7123 11 executed execute VBN cord-010092-uftc8inx 7123 12 . . . cord-010092-uftc8inx 7124 1 About about IN cord-010092-uftc8inx 7124 2 the the DT cord-010092-uftc8inx 7124 3 one one CD cord-010092-uftc8inx 7124 4 - - HYPH cord-010092-uftc8inx 7124 5 year year NN cord-010092-uftc8inx 7124 6 experience experience NN cord-010092-uftc8inx 7124 7 on on IN cord-010092-uftc8inx 7124 8 routine routine JJ cord-010092-uftc8inx 7124 9 PCs pc NNS cord-010092-uftc8inx 7124 10 production production NN cord-010092-uftc8inx 7124 11 , , , cord-010092-uftc8inx 7124 12 404 404 CD cord-010092-uftc8inx 7124 13 APCs apc NNS cord-010092-uftc8inx 7124 14 ( ( -LRB- cord-010092-uftc8inx 7124 15 182 182 CD cord-010092-uftc8inx 7124 16 women woman NNS cord-010092-uftc8inx 7124 17 and and CC cord-010092-uftc8inx 7124 18 222 222 CD cord-010092-uftc8inx 7124 19 men man NNS cord-010092-uftc8inx 7124 20 ) ) -RRB- cord-010092-uftc8inx 7124 21 and and CC cord-010092-uftc8inx 7124 22 263 263 CD cord-010092-uftc8inx 7124 23 BCPCs bcpc NNS cord-010092-uftc8inx 7124 24 were be VBD cord-010092-uftc8inx 7124 25 tested test VBN cord-010092-uftc8inx 7124 26 . . . cord-010092-uftc8inx 7125 1 All all DT cord-010092-uftc8inx 7125 2 of of IN cord-010092-uftc8inx 7125 3 the the DT cord-010092-uftc8inx 7125 4 BCPCs bcpc NNS cord-010092-uftc8inx 7125 5 and and CC cord-010092-uftc8inx 7125 6 women woman NNS cord-010092-uftc8inx 7125 7 APCs apc NNS cord-010092-uftc8inx 7125 8 were be VBD cord-010092-uftc8inx 7125 9 under under IN cord-010092-uftc8inx 7125 10 the the DT cord-010092-uftc8inx 7125 11 threshold threshold NN cord-010092-uftc8inx 7125 12 after after IN cord-010092-uftc8inx 7125 13 treatment treatment NN cord-010092-uftc8inx 7125 14 . . . cord-010092-uftc8inx 7126 1 Concerning concern VBG cord-010092-uftc8inx 7126 2 men man NNS cord-010092-uftc8inx 7126 3 APCs apc NNS cord-010092-uftc8inx 7126 4 , , , cord-010092-uftc8inx 7126 5 14.0 14.0 CD cord-010092-uftc8inx 7126 6 % % NN cord-010092-uftc8inx 7126 7 of of IN cord-010092-uftc8inx 7126 8 the the DT cord-010092-uftc8inx 7126 9 PCs pc NNS cord-010092-uftc8inx 7126 10 after after IN cord-010092-uftc8inx 7126 11 treatment treatment NN cord-010092-uftc8inx 7126 12 were be VBD cord-010092-uftc8inx 7126 13 not not RB cord-010092-uftc8inx 7126 14 under under IN cord-010092-uftc8inx 7126 15 the the DT cord-010092-uftc8inx 7126 16 threshold threshold NN cord-010092-uftc8inx 7126 17 . . . cord-010092-uftc8inx 7127 1 Summary Summary NNP cord-010092-uftc8inx 7127 2 / / SYM cord-010092-uftc8inx 7127 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 7127 4 : : : cord-010092-uftc8inx 7128 1 The the DT cord-010092-uftc8inx 7128 2 device device NN cord-010092-uftc8inx 7128 3 validation validation NN cord-010092-uftc8inx 7128 4 was be VBD cord-010092-uftc8inx 7128 5 satisfied satisfied JJ cord-010092-uftc8inx 7128 6 . . . cord-010092-uftc8inx 7129 1 For for IN cord-010092-uftc8inx 7129 2 the the DT cord-010092-uftc8inx 7129 3 one one CD cord-010092-uftc8inx 7129 4 - - HYPH cord-010092-uftc8inx 7129 5 year year NN cord-010092-uftc8inx 7129 6 evaluation evaluation NN cord-010092-uftc8inx 7129 7 and and CC cord-010092-uftc8inx 7129 8 concerning concern VBG cord-010092-uftc8inx 7129 9 men man NNS cord-010092-uftc8inx 7129 10 group group NN cord-010092-uftc8inx 7129 11 APCs apc NNS cord-010092-uftc8inx 7129 12 , , , cord-010092-uftc8inx 7129 13 the the DT cord-010092-uftc8inx 7129 14 threshold threshold NN cord-010092-uftc8inx 7129 15 found find VBN cord-010092-uftc8inx 7129 16 by by IN cord-010092-uftc8inx 7129 17 Abonnenc Abonnenc NNP cord-010092-uftc8inx 7129 18 et et NNP cord-010092-uftc8inx 7129 19 al al NNP cord-010092-uftc8inx 7129 20 . . NNP cord-010092-uftc8inx 7129 21 was be VBD cord-010092-uftc8inx 7129 22 89 89 CD cord-010092-uftc8inx 7129 23 EDEL EDEL NNP cord-010092-uftc8inx 7129 24 . . . cord-010092-uftc8inx 7130 1 Our -PRON- PRP$ cord-010092-uftc8inx 7130 2 study study NN cord-010092-uftc8inx 7130 3 showed show VBD cord-010092-uftc8inx 7130 4 a a DT cord-010092-uftc8inx 7130 5 threshold threshold NN cord-010092-uftc8inx 7130 6 with with IN cord-010092-uftc8inx 7130 7 100 100 CD cord-010092-uftc8inx 7130 8 % % NN cord-010092-uftc8inx 7130 9 specificity specificity NN cord-010092-uftc8inx 7130 10 and and CC cord-010092-uftc8inx 7130 11 90 90 CD cord-010092-uftc8inx 7130 12 % % NN cord-010092-uftc8inx 7130 13 sensitivity sensitivity NN cord-010092-uftc8inx 7130 14 at at IN cord-010092-uftc8inx 7130 15 58.5 58.5 CD cord-010092-uftc8inx 7130 16 EDEL EDEL NNP cord-010092-uftc8inx 7130 17 which which WDT cord-010092-uftc8inx 7130 18 is be VBZ cord-010092-uftc8inx 7130 19 much much RB cord-010092-uftc8inx 7130 20 lower low JJR cord-010092-uftc8inx 7130 21 . . . cord-010092-uftc8inx 7131 1 Specificity specificity NN cord-010092-uftc8inx 7131 2 was be VBD cord-010092-uftc8inx 7131 3 favored favor VBN cord-010092-uftc8inx 7131 4 compared compare VBN cord-010092-uftc8inx 7131 5 to to IN cord-010092-uftc8inx 7131 6 sensitivity sensitivity NN cord-010092-uftc8inx 7131 7 but but CC cord-010092-uftc8inx 7131 8 the the DT cord-010092-uftc8inx 7131 9 analysis analysis NN cord-010092-uftc8inx 7131 10 should should MD cord-010092-uftc8inx 7131 11 be be VB cord-010092-uftc8inx 7131 12 revised revise VBN cord-010092-uftc8inx 7131 13 to to TO cord-010092-uftc8inx 7131 14 adapt adapt VB cord-010092-uftc8inx 7131 15 the the DT cord-010092-uftc8inx 7131 16 threshold threshold NN cord-010092-uftc8inx 7131 17 to to TO cord-010092-uftc8inx 7131 18 get get VB cord-010092-uftc8inx 7131 19 higher high JJR cord-010092-uftc8inx 7131 20 sensitivity sensitivity NN cord-010092-uftc8inx 7131 21 . . . cord-010092-uftc8inx 7132 1 This this DT cord-010092-uftc8inx 7132 2 can can MD cord-010092-uftc8inx 7132 3 lead lead VB cord-010092-uftc8inx 7132 4 to to TO cord-010092-uftc8inx 7132 5 reduce reduce VB cord-010092-uftc8inx 7132 6 the the DT cord-010092-uftc8inx 7132 7 non non JJ cord-010092-uftc8inx 7132 8 - - JJ cord-010092-uftc8inx 7132 9 conformity conformity NN cord-010092-uftc8inx 7132 10 and and CC cord-010092-uftc8inx 7132 11 allows allow VBZ cord-010092-uftc8inx 7132 12 measuring measure VBG cord-010092-uftc8inx 7132 13 the the DT cord-010092-uftc8inx 7132 14 AOP AOP NNP cord-010092-uftc8inx 7132 15 only only RB cord-010092-uftc8inx 7132 16 after after IN cord-010092-uftc8inx 7132 17 treatment treatment NN cord-010092-uftc8inx 7132 18 . . . cord-010092-uftc8inx 7133 1 For for IN cord-010092-uftc8inx 7133 2 women woman NNS cord-010092-uftc8inx 7133 3 , , , cord-010092-uftc8inx 7133 4 our -PRON- PRP$ cord-010092-uftc8inx 7133 5 threshold threshold NN cord-010092-uftc8inx 7133 6 was be VBD cord-010092-uftc8inx 7133 7 found find VBN cord-010092-uftc8inx 7133 8 at at IN cord-010092-uftc8inx 7133 9 62.5 62.5 CD cord-010092-uftc8inx 7133 10 EDEL EDEL NNP cord-010092-uftc8inx 7133 11 compared compare VBN cord-010092-uftc8inx 7133 12 to to IN cord-010092-uftc8inx 7133 13 66.5 66.5 CD cord-010092-uftc8inx 7133 14 EDEL EDEL NNP cord-010092-uftc8inx 7133 15 for for IN cord-010092-uftc8inx 7133 16 Abonnenc Abonnenc NNP cord-010092-uftc8inx 7133 17 et et NNP cord-010092-uftc8inx 7133 18 al al NNP cord-010092-uftc8inx 7133 19 . . . cord-010092-uftc8inx 7134 1 Concerning concern VBG cord-010092-uftc8inx 7134 2 sex sex NN cord-010092-uftc8inx 7134 3 in in IN cord-010092-uftc8inx 7134 4 APCs apc NNS cord-010092-uftc8inx 7134 5 , , , cord-010092-uftc8inx 7134 6 results result NNS cord-010092-uftc8inx 7134 7 were be VBD cord-010092-uftc8inx 7134 8 statistically statistically RB cord-010092-uftc8inx 7134 9 lower low JJR cord-010092-uftc8inx 7134 10 in in IN cord-010092-uftc8inx 7134 11 women woman NNS cord-010092-uftc8inx 7134 12 group group NN cord-010092-uftc8inx 7134 13 than than IN cord-010092-uftc8inx 7134 14 men man NNS cord-010092-uftc8inx 7134 15 group group NN cord-010092-uftc8inx 7134 16 before before RB cord-010092-uftc8inx 7134 17 and and CC cord-010092-uftc8inx 7134 18 after after IN cord-010092-uftc8inx 7134 19 treatment treatment NN cord-010092-uftc8inx 7134 20 . . . cord-010092-uftc8inx 7135 1 And and CC cord-010092-uftc8inx 7135 2 for for IN cord-010092-uftc8inx 7135 3 BCPCs bcpc NNS cord-010092-uftc8inx 7135 4 , , , cord-010092-uftc8inx 7135 5 the the DT cord-010092-uftc8inx 7135 6 two two CD cord-010092-uftc8inx 7135 7 populations population NNS cord-010092-uftc8inx 7135 8 ( ( -LRB- cord-010092-uftc8inx 7135 9 before before IN cord-010092-uftc8inx 7135 10 and and CC cord-010092-uftc8inx 7135 11 after after IN cord-010092-uftc8inx 7135 12 treatment treatment NN cord-010092-uftc8inx 7135 13 ) ) -RRB- cord-010092-uftc8inx 7135 14 were be VBD cord-010092-uftc8inx 7135 15 very very RB cord-010092-uftc8inx 7135 16 distinguishable distinguishable JJ cord-010092-uftc8inx 7135 17 and and CC cord-010092-uftc8inx 7135 18 our -PRON- PRP$ cord-010092-uftc8inx 7135 19 threshold threshold NN cord-010092-uftc8inx 7135 20 ( ( -LRB- cord-010092-uftc8inx 7135 21 54 54 CD cord-010092-uftc8inx 7135 22 EDEL EDEL NNP cord-010092-uftc8inx 7135 23 ) ) -RRB- cord-010092-uftc8inx 7135 24 was be VBD cord-010092-uftc8inx 7135 25 lower low JJR cord-010092-uftc8inx 7135 26 than than IN cord-010092-uftc8inx 7135 27 Abonnenc Abonnenc NNP cord-010092-uftc8inx 7135 28 threshold threshold NN cord-010092-uftc8inx 7135 29 which which WDT cord-010092-uftc8inx 7135 30 was be VBD cord-010092-uftc8inx 7135 31 at at IN cord-010092-uftc8inx 7135 32 59.8 59.8 CD cord-010092-uftc8inx 7135 33 EDEL EDEL NNP cord-010092-uftc8inx 7135 34 . . . cord-010092-uftc8inx 7136 1 In in IN cord-010092-uftc8inx 7136 2 conclusion conclusion NN cord-010092-uftc8inx 7136 3 , , , cord-010092-uftc8inx 7136 4 EDEL EDEL NNP cord-010092-uftc8inx 7136 5 threshold threshold NN cord-010092-uftc8inx 7136 6 enables enable VBZ cord-010092-uftc8inx 7136 7 the the DT cord-010092-uftc8inx 7136 8 segregation segregation NN cord-010092-uftc8inx 7136 9 and and CC cord-010092-uftc8inx 7136 10 depends depend VBZ cord-010092-uftc8inx 7136 11 on on IN cord-010092-uftc8inx 7136 12 the the DT cord-010092-uftc8inx 7136 13 preparation preparation NN cord-010092-uftc8inx 7136 14 process process NN cord-010092-uftc8inx 7136 15 adapted adapt VBN cord-010092-uftc8inx 7136 16 in in IN cord-010092-uftc8inx 7136 17 each each DT cord-010092-uftc8inx 7136 18 blood blood NN cord-010092-uftc8inx 7136 19 service service NN cord-010092-uftc8inx 7136 20 . . . cord-010092-uftc8inx 7137 1 Aims aim VBZ cord-010092-uftc8inx 7137 2 : : : cord-010092-uftc8inx 7138 1 This this DT cord-010092-uftc8inx 7138 2 study study NN cord-010092-uftc8inx 7138 3 has have VBZ cord-010092-uftc8inx 7138 4 the the DT cord-010092-uftc8inx 7138 5 goal goal NN cord-010092-uftc8inx 7138 6 of of IN cord-010092-uftc8inx 7138 7 measuring measure VBG cord-010092-uftc8inx 7138 8 antioxidant antioxidant JJ cord-010092-uftc8inx 7138 9 power power NN cord-010092-uftc8inx 7138 10 ( ( -LRB- cord-010092-uftc8inx 7138 11 AOP AOP NNP cord-010092-uftc8inx 7138 12 ) ) -RRB- cord-010092-uftc8inx 7138 13 level level NN cord-010092-uftc8inx 7138 14 in in IN cord-010092-uftc8inx 7138 15 plasma plasma NN cord-010092-uftc8inx 7138 16 units unit NNS cord-010092-uftc8inx 7138 17 treated treat VBN cord-010092-uftc8inx 7138 18 by by IN cord-010092-uftc8inx 7138 19 MB mb NN cord-010092-uftc8inx 7138 20 technology technology NN cord-010092-uftc8inx 7138 21 . . . cord-010092-uftc8inx 7139 1 The the DT cord-010092-uftc8inx 7139 2 aim aim NN cord-010092-uftc8inx 7139 3 is be VBZ cord-010092-uftc8inx 7139 4 to to TO cord-010092-uftc8inx 7139 5 use use VB cord-010092-uftc8inx 7139 6 such such PDT cord-010092-uftc8inx 7139 7 a a DT cord-010092-uftc8inx 7139 8 test test NN cord-010092-uftc8inx 7139 9 as as IN cord-010092-uftc8inx 7139 10 a a DT cord-010092-uftc8inx 7139 11 quality quality NN cord-010092-uftc8inx 7139 12 control control NN cord-010092-uftc8inx 7139 13 assay assay NN cord-010092-uftc8inx 7139 14 for for IN cord-010092-uftc8inx 7139 15 documenting document VBG cord-010092-uftc8inx 7139 16 the the DT cord-010092-uftc8inx 7139 17 execution execution NN cord-010092-uftc8inx 7139 18 of of IN cord-010092-uftc8inx 7139 19 pathogen pathogen NN cord-010092-uftc8inx 7139 20 inactivation inactivation NN cord-010092-uftc8inx 7139 21 treatments treatment NNS cord-010092-uftc8inx 7139 22 during during IN cord-010092-uftc8inx 7139 23 the the DT cord-010092-uftc8inx 7139 24 preparation preparation NN cord-010092-uftc8inx 7139 25 of of IN cord-010092-uftc8inx 7139 26 plasma plasma NN cord-010092-uftc8inx 7139 27 units unit NNS cord-010092-uftc8inx 7139 28 . . . cord-010092-uftc8inx 7140 1 Methods method NNS cord-010092-uftc8inx 7140 2 : : : cord-010092-uftc8inx 7140 3 AOP AOP NNP cord-010092-uftc8inx 7140 4 measurements measurement NNS cord-010092-uftc8inx 7140 5 were be VBD cord-010092-uftc8inx 7140 6 performed perform VBN cord-010092-uftc8inx 7140 7 using use VBG cord-010092-uftc8inx 7140 8 a a DT cord-010092-uftc8inx 7140 9 potentiostat potentiostat JJ cord-010092-uftc8inx 7140 10 electrochemical electrochemical JJ cord-010092-uftc8inx 7140 11 analyzer analyzer NN cord-010092-uftc8inx 7140 12 . . . cord-010092-uftc8inx 7141 1 A a DT cord-010092-uftc8inx 7141 2 3-ll 3-ll CD cord-010092-uftc8inx 7141 3 volume volume NN cord-010092-uftc8inx 7141 4 of of IN cord-010092-uftc8inx 7141 5 sample sample NN cord-010092-uftc8inx 7141 6 is be VBZ cord-010092-uftc8inx 7141 7 deposited deposit VBN cord-010092-uftc8inx 7141 8 over over IN cord-010092-uftc8inx 7141 9 the the DT cord-010092-uftc8inx 7141 10 electrodes electrode NNS cord-010092-uftc8inx 7141 11 on on IN cord-010092-uftc8inx 7141 12 a a DT cord-010092-uftc8inx 7141 13 single single JJ cord-010092-uftc8inx 7141 14 - - HYPH cord-010092-uftc8inx 7141 15 use use NN cord-010092-uftc8inx 7141 16 microship microship NN cord-010092-uftc8inx 7141 17 . . . cord-010092-uftc8inx 7142 1 The the DT cord-010092-uftc8inx 7142 2 AOP AOP NNP cord-010092-uftc8inx 7142 3 is be VBZ cord-010092-uftc8inx 7142 4 expressed express VBN cord-010092-uftc8inx 7142 5 in in IN cord-010092-uftc8inx 7142 6 EDEL EDEL NNP cord-010092-uftc8inx 7142 7 value value NN cord-010092-uftc8inx 7142 8 , , , cord-010092-uftc8inx 7142 9 one one CD cord-010092-uftc8inx 7142 10 EDEL EDEL NNP cord-010092-uftc8inx 7142 11 being be VBG cord-010092-uftc8inx 7142 12 equivalent equivalent JJ cord-010092-uftc8inx 7142 13 to to IN cord-010092-uftc8inx 7142 14 1 1 CD cord-010092-uftc8inx 7142 15 lmol lmol NNP cord-010092-uftc8inx 7142 16 / / SYM cord-010092-uftc8inx 7142 17 L l NN cord-010092-uftc8inx 7142 18 ascorbic ascorbic NN cord-010092-uftc8inx 7142 19 acid acid NN cord-010092-uftc8inx 7142 20 and and CC cord-010092-uftc8inx 7142 21 reflects reflect VBZ cord-010092-uftc8inx 7142 22 the the DT cord-010092-uftc8inx 7142 23 redox redox JJ cord-010092-uftc8inx 7142 24 status status NN cord-010092-uftc8inx 7142 25 of of IN cord-010092-uftc8inx 7142 26 the the DT cord-010092-uftc8inx 7142 27 plasma plasma NN cord-010092-uftc8inx 7142 28 units unit NNS cord-010092-uftc8inx 7142 29 . . . cord-010092-uftc8inx 7143 1 Different different JJ cord-010092-uftc8inx 7143 2 protocols protocol NNS cord-010092-uftc8inx 7143 3 were be VBD cord-010092-uftc8inx 7143 4 established establish VBN cord-010092-uftc8inx 7143 5 to to TO cord-010092-uftc8inx 7143 6 understand understand VB cord-010092-uftc8inx 7143 7 the the DT cord-010092-uftc8inx 7143 8 role role NN cord-010092-uftc8inx 7143 9 of of IN cord-010092-uftc8inx 7143 10 MB mb NN cord-010092-uftc8inx 7143 11 , , , cord-010092-uftc8inx 7143 12 the the DT cord-010092-uftc8inx 7143 13 illumination illumination NN cord-010092-uftc8inx 7143 14 and and CC cord-010092-uftc8inx 7143 15 the the DT cord-010092-uftc8inx 7143 16 filtration filtration NN cord-010092-uftc8inx 7143 17 on on IN cord-010092-uftc8inx 7143 18 the the DT cord-010092-uftc8inx 7143 19 AOP AOP NNP cord-010092-uftc8inx 7143 20 variation variation NN cord-010092-uftc8inx 7143 21 measure measure NN cord-010092-uftc8inx 7143 22 : : : cord-010092-uftc8inx 7143 23 1 1 LS cord-010092-uftc8inx 7143 24 ) ) -RRB- cord-010092-uftc8inx 7143 25 complete complete JJ cord-010092-uftc8inx 7143 26 treatment treatment NN cord-010092-uftc8inx 7143 27 , , , cord-010092-uftc8inx 7143 28 2 2 CD cord-010092-uftc8inx 7143 29 ) ) -RRB- cord-010092-uftc8inx 7143 30 plasmas plasma NNS cord-010092-uftc8inx 7143 31 with with IN cord-010092-uftc8inx 7143 32 MB mb NN cord-010092-uftc8inx 7143 33 without without IN cord-010092-uftc8inx 7143 34 illumination illumination NN cord-010092-uftc8inx 7143 35 , , , cord-010092-uftc8inx 7143 36 3 3 CD cord-010092-uftc8inx 7143 37 ) ) -RRB- cord-010092-uftc8inx 7143 38 plasmas plasma NNS cord-010092-uftc8inx 7143 39 without without IN cord-010092-uftc8inx 7143 40 MB mb NN cord-010092-uftc8inx 7143 41 with with IN cord-010092-uftc8inx 7143 42 illumination illumination NN cord-010092-uftc8inx 7143 43 and and CC cord-010092-uftc8inx 7143 44 4 4 CD cord-010092-uftc8inx 7143 45 ) ) -RRB- cord-010092-uftc8inx 7143 46 plasmas plasma NNS cord-010092-uftc8inx 7143 47 without without IN cord-010092-uftc8inx 7143 48 MB mb NN cord-010092-uftc8inx 7143 49 without without IN cord-010092-uftc8inx 7143 50 illumination illumination NN cord-010092-uftc8inx 7143 51 . . . cord-010092-uftc8inx 7144 1 Ten ten CD cord-010092-uftc8inx 7144 2 dosages dosage NNS cord-010092-uftc8inx 7144 3 on on IN cord-010092-uftc8inx 7144 4 men man NNS cord-010092-uftc8inx 7144 5 donor donor NN cord-010092-uftc8inx 7144 6 samples sample NNS cord-010092-uftc8inx 7144 7 , , , cord-010092-uftc8inx 7144 8 except except IN cord-010092-uftc8inx 7144 9 for for IN cord-010092-uftc8inx 7144 10 protocol protocol NN cord-010092-uftc8inx 7144 11 1 1 CD cord-010092-uftc8inx 7144 12 where where WRB cord-010092-uftc8inx 7144 13 n n NN cord-010092-uftc8inx 7144 14 = = SYM cord-010092-uftc8inx 7144 15 20 20 CD cord-010092-uftc8inx 7144 16 , , , cord-010092-uftc8inx 7144 17 were be VBD cord-010092-uftc8inx 7144 18 realized realize VBN cord-010092-uftc8inx 7144 19 during during IN cord-010092-uftc8inx 7144 20 the the DT cord-010092-uftc8inx 7144 21 viro viro NN cord-010092-uftc8inx 7144 22 - - HYPH cord-010092-uftc8inx 7144 23 inactivation inactivation NN cord-010092-uftc8inx 7144 24 process process NN cord-010092-uftc8inx 7144 25 , , , cord-010092-uftc8inx 7144 26 T1 T1 NNP cord-010092-uftc8inx 7144 27 corresponds correspond VBZ cord-010092-uftc8inx 7144 28 to to IN cord-010092-uftc8inx 7144 29 a a DT cord-010092-uftc8inx 7144 30 dosage dosage NN cord-010092-uftc8inx 7144 31 of of IN cord-010092-uftc8inx 7144 32 plasmas plasma NNS cord-010092-uftc8inx 7144 33 before before IN cord-010092-uftc8inx 7144 34 treatment treatment NN cord-010092-uftc8inx 7144 35 , , , cord-010092-uftc8inx 7144 36 T2 T2 NNP cord-010092-uftc8inx 7144 37 the the DT cord-010092-uftc8inx 7144 38 plasma plasma NN cord-010092-uftc8inx 7144 39 after after IN cord-010092-uftc8inx 7144 40 the the DT cord-010092-uftc8inx 7144 41 MB mb NN cord-010092-uftc8inx 7144 42 dry dry JJ cord-010092-uftc8inx 7144 43 tablet tablet NN cord-010092-uftc8inx 7144 44 passage passage NN cord-010092-uftc8inx 7144 45 , , , cord-010092-uftc8inx 7144 46 T3 T3 NNP cord-010092-uftc8inx 7144 47 is be VBZ cord-010092-uftc8inx 7144 48 the the DT cord-010092-uftc8inx 7144 49 time time NN cord-010092-uftc8inx 7144 50 after after IN cord-010092-uftc8inx 7144 51 illumination illumination NN cord-010092-uftc8inx 7144 52 and and CC cord-010092-uftc8inx 7144 53 T4 T4 NNP cord-010092-uftc8inx 7144 54 corresponds correspond VBZ cord-010092-uftc8inx 7144 55 to to IN cord-010092-uftc8inx 7144 56 the the DT cord-010092-uftc8inx 7144 57 final final JJ cord-010092-uftc8inx 7144 58 product product NN cord-010092-uftc8inx 7144 59 ( ( -LRB- cord-010092-uftc8inx 7144 60 after after IN cord-010092-uftc8inx 7144 61 filtration filtration NN cord-010092-uftc8inx 7144 62 ) ) -RRB- cord-010092-uftc8inx 7144 63 . . . cord-010092-uftc8inx 7145 1 Results result NNS cord-010092-uftc8inx 7145 2 : : : cord-010092-uftc8inx 7146 1 In in IN cord-010092-uftc8inx 7146 2 each each DT cord-010092-uftc8inx 7146 3 protocol protocol NN cord-010092-uftc8inx 7146 4 with with IN cord-010092-uftc8inx 7146 5 MB mb NN cord-010092-uftc8inx 7146 6 , , , cord-010092-uftc8inx 7146 7 an an DT cord-010092-uftc8inx 7146 8 increase increase NN cord-010092-uftc8inx 7146 9 was be VBD cord-010092-uftc8inx 7146 10 observed observe VBN cord-010092-uftc8inx 7146 11 after after IN cord-010092-uftc8inx 7146 12 addition addition NN cord-010092-uftc8inx 7146 13 of of IN cord-010092-uftc8inx 7146 14 MB mb NN cord-010092-uftc8inx 7146 15 before before IN cord-010092-uftc8inx 7146 16 illumination illumination NN cord-010092-uftc8inx 7146 17 . . . cord-010092-uftc8inx 7147 1 After after IN cord-010092-uftc8inx 7147 2 illumination illumination NN cord-010092-uftc8inx 7147 3 , , , cord-010092-uftc8inx 7147 4 the the DT cord-010092-uftc8inx 7147 5 EDEL edel JJ cord-010092-uftc8inx 7147 6 values value NNS cord-010092-uftc8inx 7147 7 decreased decrease VBD cord-010092-uftc8inx 7147 8 for for IN cord-010092-uftc8inx 7147 9 about about RB cord-010092-uftc8inx 7147 10 less less JJR cord-010092-uftc8inx 7147 11 than than IN cord-010092-uftc8inx 7147 12 50 50 CD cord-010092-uftc8inx 7147 13 % % NN cord-010092-uftc8inx 7147 14 , , , cord-010092-uftc8inx 7147 15 which which WDT cord-010092-uftc8inx 7147 16 was be VBD cord-010092-uftc8inx 7147 17 expected expect VBN cord-010092-uftc8inx 7147 18 because because IN cord-010092-uftc8inx 7147 19 of of IN cord-010092-uftc8inx 7147 20 the the DT cord-010092-uftc8inx 7147 21 degradation degradation NN cord-010092-uftc8inx 7147 22 of of IN cord-010092-uftc8inx 7147 23 MB mb NN cord-010092-uftc8inx 7147 24 in in IN cord-010092-uftc8inx 7147 25 its -PRON- PRP$ cord-010092-uftc8inx 7147 26 photoproducts photoproduct NNS cord-010092-uftc8inx 7147 27 during during IN cord-010092-uftc8inx 7147 28 the the DT cord-010092-uftc8inx 7147 29 illumination illumination NN cord-010092-uftc8inx 7147 30 . . . cord-010092-uftc8inx 7148 1 In in IN cord-010092-uftc8inx 7148 2 the the DT cord-010092-uftc8inx 7148 3 series series NN cord-010092-uftc8inx 7148 4 1 1 CD cord-010092-uftc8inx 7148 5 and and CC cord-010092-uftc8inx 7148 6 3 3 CD cord-010092-uftc8inx 7148 7 , , , cord-010092-uftc8inx 7148 8 the the DT cord-010092-uftc8inx 7148 9 illumination illumination NN cord-010092-uftc8inx 7148 10 seemed seem VBD cord-010092-uftc8inx 7148 11 to to TO cord-010092-uftc8inx 7148 12 have have VB cord-010092-uftc8inx 7148 13 an an DT cord-010092-uftc8inx 7148 14 effect effect NN cord-010092-uftc8inx 7148 15 by by IN cord-010092-uftc8inx 7148 16 itself -PRON- PRP cord-010092-uftc8inx 7148 17 , , , cord-010092-uftc8inx 7148 18 with with IN cord-010092-uftc8inx 7148 19 or or CC cord-010092-uftc8inx 7148 20 without without IN cord-010092-uftc8inx 7148 21 MB mb NN cord-010092-uftc8inx 7148 22 because because IN cord-010092-uftc8inx 7148 23 the the DT cord-010092-uftc8inx 7148 24 AOP AOP NNP cord-010092-uftc8inx 7148 25 increased increase VBD cord-010092-uftc8inx 7148 26 . . . cord-010092-uftc8inx 7149 1 The the DT cord-010092-uftc8inx 7149 2 final final JJ cord-010092-uftc8inx 7149 3 filtration filtration NN cord-010092-uftc8inx 7149 4 has have VBZ cord-010092-uftc8inx 7149 5 the the DT cord-010092-uftc8inx 7149 6 goal goal NN cord-010092-uftc8inx 7149 7 to to TO cord-010092-uftc8inx 7149 8 eliminate eliminate VB cord-010092-uftc8inx 7149 9 the the DT cord-010092-uftc8inx 7149 10 residual residual JJ cord-010092-uftc8inx 7149 11 MB mb NN cord-010092-uftc8inx 7149 12 and and CC cord-010092-uftc8inx 7149 13 its -PRON- PRP$ cord-010092-uftc8inx 7149 14 photoproducts photoproduct NNS cord-010092-uftc8inx 7149 15 . . . cord-010092-uftc8inx 7150 1 After after IN cord-010092-uftc8inx 7150 2 this this DT cord-010092-uftc8inx 7150 3 step step NN cord-010092-uftc8inx 7150 4 , , , cord-010092-uftc8inx 7150 5 the the DT cord-010092-uftc8inx 7150 6 AOP aop NN cord-010092-uftc8inx 7150 7 values value NNS cord-010092-uftc8inx 7150 8 fell fall VBD cord-010092-uftc8inx 7150 9 down down RB cord-010092-uftc8inx 7150 10 . . . cord-010092-uftc8inx 7151 1 The the DT cord-010092-uftc8inx 7151 2 series series NN cord-010092-uftc8inx 7151 3 2 2 CD cord-010092-uftc8inx 7151 4 was be VBD cord-010092-uftc8inx 7151 5 a a DT cord-010092-uftc8inx 7151 6 confirmation confirmation NN cord-010092-uftc8inx 7151 7 of of IN cord-010092-uftc8inx 7151 8 the the DT cord-010092-uftc8inx 7151 9 efficacy efficacy NN cord-010092-uftc8inx 7151 10 of of IN cord-010092-uftc8inx 7151 11 the the DT cord-010092-uftc8inx 7151 12 filter filter NN cord-010092-uftc8inx 7151 13 to to TO cord-010092-uftc8inx 7151 14 remove remove VB cord-010092-uftc8inx 7151 15 the the DT cord-010092-uftc8inx 7151 16 MB mb NN cord-010092-uftc8inx 7151 17 as as IN cord-010092-uftc8inx 7151 18 shown show VBN cord-010092-uftc8inx 7151 19 by by IN cord-010092-uftc8inx 7151 20 the the DT cord-010092-uftc8inx 7151 21 decreased decrease VBN cord-010092-uftc8inx 7151 22 AOP AOP NNP cord-010092-uftc8inx 7151 23 in in IN cord-010092-uftc8inx 7151 24 T4 T4 NNP cord-010092-uftc8inx 7151 25 ( ( -LRB- cord-010092-uftc8inx 7151 26 238 238 CD cord-010092-uftc8inx 7151 27 AE AE NNP cord-010092-uftc8inx 7151 28 16 16 CD cord-010092-uftc8inx 7151 29 EDEL EDEL NNP cord-010092-uftc8inx 7151 30 at at IN cord-010092-uftc8inx 7151 31 T3 T3 NNP cord-010092-uftc8inx 7151 32 and and CC cord-010092-uftc8inx 7151 33 209 209 CD cord-010092-uftc8inx 7151 34 AE AE NNP cord-010092-uftc8inx 7151 35 17 17 CD cord-010092-uftc8inx 7151 36 EDEL EDEL NNP cord-010092-uftc8inx 7151 37 at at IN cord-010092-uftc8inx 7151 38 T4 T4 NNP cord-010092-uftc8inx 7151 39 ) ) -RRB- cord-010092-uftc8inx 7151 40 . . . cord-010092-uftc8inx 7152 1 However however RB cord-010092-uftc8inx 7152 2 , , , cord-010092-uftc8inx 7152 3 in in IN cord-010092-uftc8inx 7152 4 the the DT cord-010092-uftc8inx 7152 5 absence absence NN cord-010092-uftc8inx 7152 6 of of IN cord-010092-uftc8inx 7152 7 MB MB NNP cord-010092-uftc8inx 7152 8 ( ( -LRB- cord-010092-uftc8inx 7152 9 series series NN cord-010092-uftc8inx 7152 10 3 3 CD cord-010092-uftc8inx 7152 11 and and CC cord-010092-uftc8inx 7152 12 4 4 CD cord-010092-uftc8inx 7152 13 ) ) -RRB- cord-010092-uftc8inx 7152 14 , , , cord-010092-uftc8inx 7152 15 the the DT cord-010092-uftc8inx 7152 16 results result NNS cord-010092-uftc8inx 7152 17 at at IN cord-010092-uftc8inx 7152 18 T1 T1 NNP cord-010092-uftc8inx 7152 19 and and CC cord-010092-uftc8inx 7152 20 T4 T4 NNP cord-010092-uftc8inx 7152 21 were be VBD cord-010092-uftc8inx 7152 22 not not RB cord-010092-uftc8inx 7152 23 statistically statistically RB cord-010092-uftc8inx 7152 24 different different JJ cord-010092-uftc8inx 7152 25 . . . cord-010092-uftc8inx 7153 1 Summary Summary NNP cord-010092-uftc8inx 7153 2 / / SYM cord-010092-uftc8inx 7153 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 7153 4 : : : cord-010092-uftc8inx 7154 1 The the DT cord-010092-uftc8inx 7154 2 filtration filtration NN cord-010092-uftc8inx 7154 3 decreases decrease VBZ cord-010092-uftc8inx 7154 4 the the DT cord-010092-uftc8inx 7154 5 AOP aop NN cord-010092-uftc8inx 7154 6 rate rate NN cord-010092-uftc8inx 7154 7 , , , cord-010092-uftc8inx 7154 8 except except IN cord-010092-uftc8inx 7154 9 when when WRB cord-010092-uftc8inx 7154 10 there there EX cord-010092-uftc8inx 7154 11 was be VBD cord-010092-uftc8inx 7154 12 no no DT cord-010092-uftc8inx 7154 13 MB mb NN cord-010092-uftc8inx 7154 14 . . . cord-010092-uftc8inx 7155 1 The the DT cord-010092-uftc8inx 7155 2 results result NNS cord-010092-uftc8inx 7155 3 of of IN cord-010092-uftc8inx 7155 4 non non JJ cord-010092-uftc8inx 7155 5 - - JJ cord-010092-uftc8inx 7155 6 complete complete JJ cord-010092-uftc8inx 7155 7 viro viro NN cord-010092-uftc8inx 7155 8 - - HYPH cord-010092-uftc8inx 7155 9 inactivation inactivation NN cord-010092-uftc8inx 7155 10 treatment treatment NN cord-010092-uftc8inx 7155 11 allow allow VBP cord-010092-uftc8inx 7155 12 concluding conclude VBG cord-010092-uftc8inx 7155 13 that that IN cord-010092-uftc8inx 7155 14 the the DT cord-010092-uftc8inx 7155 15 measure measure NN cord-010092-uftc8inx 7155 16 of of IN cord-010092-uftc8inx 7155 17 AOP AOP NNP cord-010092-uftc8inx 7155 18 rate rate NN cord-010092-uftc8inx 7155 19 may may MD cord-010092-uftc8inx 7155 20 not not RB cord-010092-uftc8inx 7155 21 indicate indicate VB cord-010092-uftc8inx 7155 22 that that IN cord-010092-uftc8inx 7155 23 the the DT cord-010092-uftc8inx 7155 24 treatment treatment NN cord-010092-uftc8inx 7155 25 was be VBD cord-010092-uftc8inx 7155 26 completed complete VBN cord-010092-uftc8inx 7155 27 or or CC cord-010092-uftc8inx 7155 28 not not RB cord-010092-uftc8inx 7155 29 since since IN cord-010092-uftc8inx 7155 30 significant significant JJ cord-010092-uftc8inx 7155 31 differences difference NNS cord-010092-uftc8inx 7155 32 before before IN cord-010092-uftc8inx 7155 33 and and CC cord-010092-uftc8inx 7155 34 after after IN cord-010092-uftc8inx 7155 35 treatments treatment NNS cord-010092-uftc8inx 7155 36 were be VBD cord-010092-uftc8inx 7155 37 found find VBN cord-010092-uftc8inx 7155 38 in in IN cord-010092-uftc8inx 7155 39 the the DT cord-010092-uftc8inx 7155 40 non non JJ cord-010092-uftc8inx 7155 41 - - JJ cord-010092-uftc8inx 7155 42 complete complete JJ cord-010092-uftc8inx 7155 43 treatment treatment NN cord-010092-uftc8inx 7155 44 series series NN cord-010092-uftc8inx 7155 45 . . . cord-010092-uftc8inx 7156 1 Vox Vox NNP cord-010092-uftc8inx 7156 2 Sanguinis Sanguinis NNP cord-010092-uftc8inx 7156 3 ( ( -LRB- cord-010092-uftc8inx 7156 4 2019 2019 CD cord-010092-uftc8inx 7156 5 ) ) -RRB- cord-010092-uftc8inx 7157 1 Background background NN cord-010092-uftc8inx 7157 2 : : : cord-010092-uftc8inx 7158 1 The the DT cord-010092-uftc8inx 7158 2 INTERCEPT INTERCEPT NNP cord-010092-uftc8inx 7158 3 Blood blood NN cord-010092-uftc8inx 7158 4 System System NNP cord-010092-uftc8inx 7158 5 ( ( -LRB- cord-010092-uftc8inx 7158 6 IBS IBS NNP cord-010092-uftc8inx 7158 7 ) ) -RRB- cord-010092-uftc8inx 7158 8 , , , cord-010092-uftc8inx 7158 9 a a DT cord-010092-uftc8inx 7158 10 photochemical photochemical JJ cord-010092-uftc8inx 7158 11 treatment treatment NN cord-010092-uftc8inx 7158 12 with with IN cord-010092-uftc8inx 7158 13 Amotosalen Amotosalen NNP cord-010092-uftc8inx 7158 14 and and CC cord-010092-uftc8inx 7158 15 UVA UVA NNP cord-010092-uftc8inx 7158 16 , , , cord-010092-uftc8inx 7158 17 is be VBZ cord-010092-uftc8inx 7158 18 used use VBN cord-010092-uftc8inx 7158 19 to to TO cord-010092-uftc8inx 7158 20 inactivate inactivate VB cord-010092-uftc8inx 7158 21 pathogens pathogen NNS cord-010092-uftc8inx 7158 22 and and CC cord-010092-uftc8inx 7158 23 leukocytes leukocyte NNS cord-010092-uftc8inx 7158 24 in in IN cord-010092-uftc8inx 7158 25 plasma plasma NN cord-010092-uftc8inx 7158 26 . . . cord-010092-uftc8inx 7159 1 The the DT cord-010092-uftc8inx 7159 2 INTERCEPT INTERCEPT NNP cord-010092-uftc8inx 7159 3 TM TM NNP cord-010092-uftc8inx 7159 4 plasma plasma NN cord-010092-uftc8inx 7159 5 processing processing NN cord-010092-uftc8inx 7159 6 set set NN cord-010092-uftc8inx 7159 7 ( ( -LRB- cord-010092-uftc8inx 7159 8 Cerus Cerus NNP cord-010092-uftc8inx 7159 9 BV BV NNP cord-010092-uftc8inx 7159 10 , , , cord-010092-uftc8inx 7159 11 Netherlands Netherlands NNP cord-010092-uftc8inx 7159 12 ) ) -RRB- cord-010092-uftc8inx 7159 13 was be VBD cord-010092-uftc8inx 7159 14 modified modify VBN cord-010092-uftc8inx 7159 15 to to TO cord-010092-uftc8inx 7159 16 incorporate incorporate VB cord-010092-uftc8inx 7159 17 plastic plastic JJ cord-010092-uftc8inx 7159 18 containers container NNS cord-010092-uftc8inx 7159 19 in in IN cord-010092-uftc8inx 7159 20 non non JJ cord-010092-uftc8inx 7159 21 - - JJ cord-010092-uftc8inx 7159 22 PVC pvc JJ cord-010092-uftc8inx 7159 23 materials material NNS cord-010092-uftc8inx 7159 24 sourced source VBN cord-010092-uftc8inx 7159 25 from from IN cord-010092-uftc8inx 7159 26 alternate alternate JJ cord-010092-uftc8inx 7159 27 suppliers supplier NNS cord-010092-uftc8inx 7159 28 and and CC cord-010092-uftc8inx 7159 29 connecting connect VBG cord-010092-uftc8inx 7159 30 parts part NNS cord-010092-uftc8inx 7159 31 and and CC cord-010092-uftc8inx 7159 32 accessories accessory NNS cord-010092-uftc8inx 7159 33 in in IN cord-010092-uftc8inx 7159 34 non non JJ cord-010092-uftc8inx 7159 35 - - JJ cord-010092-uftc8inx 7159 36 DEHP dehp JJ cord-010092-uftc8inx 7159 37 PVC pvc NN cord-010092-uftc8inx 7159 38 formulations formulation NNS cord-010092-uftc8inx 7159 39 , , , cord-010092-uftc8inx 7159 40 making make VBG cord-010092-uftc8inx 7159 41 the the DT cord-010092-uftc8inx 7159 42 system system NN cord-010092-uftc8inx 7159 43 DEHP dehp NN cord-010092-uftc8inx 7159 44 - - HYPH cord-010092-uftc8inx 7159 45 free free JJ cord-010092-uftc8inx 7159 46 . . . cord-010092-uftc8inx 7160 1 The the DT cord-010092-uftc8inx 7160 2 final final JJ cord-010092-uftc8inx 7160 3 storage storage NN cord-010092-uftc8inx 7160 4 container container NN cord-010092-uftc8inx 7160 5 was be VBD cord-010092-uftc8inx 7160 6 modified modify VBN cord-010092-uftc8inx 7160 7 with with IN cord-010092-uftc8inx 7160 8 a a DT cord-010092-uftc8inx 7160 9 higher high JJR cord-010092-uftc8inx 7160 10 contact contact NN cord-010092-uftc8inx 7160 11 surface surface NN cord-010092-uftc8inx 7160 12 with with IN cord-010092-uftc8inx 7160 13 plasma plasma NN cord-010092-uftc8inx 7160 14 to to TO cord-010092-uftc8inx 7160 15 limit limit VB cord-010092-uftc8inx 7160 16 the the DT cord-010092-uftc8inx 7160 17 thawing thaw VBG cord-010092-uftc8inx 7160 18 time time NN cord-010092-uftc8inx 7160 19 . . . cord-010092-uftc8inx 7161 1 proportion proportion NN cord-010092-uftc8inx 7161 2 of of IN cord-010092-uftc8inx 7161 3 units unit NNS cord-010092-uftc8inx 7161 4 with with IN cord-010092-uftc8inx 7161 5 a a DT cord-010092-uftc8inx 7161 6 fibrinogen fibrinogen NN cord-010092-uftc8inx 7161 7 concentration concentration NN cord-010092-uftc8inx 7161 8 ≥ ≥ CD cord-010092-uftc8inx 7162 1 2.00 2.00 CD cord-010092-uftc8inx 7162 2 g g NNP cord-010092-uftc8inx 7162 3 / / SYM cord-010092-uftc8inx 7162 4 L L NNP cord-010092-uftc8inx 7162 5 was be VBD cord-010092-uftc8inx 7162 6 94 94 CD cord-010092-uftc8inx 7162 7 % % NN cord-010092-uftc8inx 7162 8 ( ( -LRB- cord-010092-uftc8inx 7162 9 > > NFP cord-010092-uftc8inx 7162 10 70 70 CD cord-010092-uftc8inx 7162 11 % % NN cord-010092-uftc8inx 7162 12 required require VBN cord-010092-uftc8inx 7162 13 ) ) -RRB- cord-010092-uftc8inx 7162 14 . . . cord-010092-uftc8inx 7163 1 Mean mean JJ cord-010092-uftc8inx 7163 2 recovery recovery NN cord-010092-uftc8inx 7163 3 FVIII fviii NN cord-010092-uftc8inx 7163 4 fibrinogen fibrinogen NN cord-010092-uftc8inx 7163 5 after after IN cord-010092-uftc8inx 7163 6 IBS IBS NNP cord-010092-uftc8inx 7163 7 treatment treatment NN cord-010092-uftc8inx 7163 8 and and CC cord-010092-uftc8inx 7163 9 frozen frozen JJ cord-010092-uftc8inx 7163 10 storage storage NN cord-010092-uftc8inx 7163 11 were be VBD cord-010092-uftc8inx 7163 12 75 75 CD cord-010092-uftc8inx 7163 13 % % NN cord-010092-uftc8inx 7163 14 and and CC cord-010092-uftc8inx 7163 15 90 90 CD cord-010092-uftc8inx 7163 16 % % NN cord-010092-uftc8inx 7163 17 , , , cord-010092-uftc8inx 7163 18 respectively respectively RB cord-010092-uftc8inx 7163 19 . . . cord-010092-uftc8inx 7164 1 Residual residual JJ cord-010092-uftc8inx 7164 2 platelets platelet NNS cord-010092-uftc8inx 7164 3 were be VBD cord-010092-uftc8inx 7164 4 < < XX cord-010092-uftc8inx 7164 5 25 25 CD cord-010092-uftc8inx 7164 6 9 9 CD cord-010092-uftc8inx 7164 7 10 10 CD cord-010092-uftc8inx 7164 8 9 9 CD cord-010092-uftc8inx 7164 9 /L /l CD cord-010092-uftc8inx 7164 10 , , , cord-010092-uftc8inx 7164 11 leucocytes leucocytes NNP cord-010092-uftc8inx 7164 12 < < XX cord-010092-uftc8inx 7164 13 1 1 CD cord-010092-uftc8inx 7164 14 9 9 CD cord-010092-uftc8inx 7164 15 10 10 CD cord-010092-uftc8inx 7164 16 4 4 CD cord-010092-uftc8inx 7164 17 /L /L , cord-010092-uftc8inx 7164 18 and and CC cord-010092-uftc8inx 7164 19 red red JJ cord-010092-uftc8inx 7164 20 blood blood NN cord-010092-uftc8inx 7164 21 cells cell NNS cord-010092-uftc8inx 7164 22 < < XX cord-010092-uftc8inx 7164 23 4 4 CD cord-010092-uftc8inx 7164 24 9 9 CD cord-010092-uftc8inx 7164 25 10 10 CD cord-010092-uftc8inx 7164 26 9 9 CD cord-010092-uftc8inx 7165 1 /L. /L. . cord-010092-uftc8inx 7166 1 All all DT cord-010092-uftc8inx 7166 2 units unit NNS cord-010092-uftc8inx 7166 3 had have VBD cord-010092-uftc8inx 7166 4 a a DT cord-010092-uftc8inx 7166 5 protein protein NN cord-010092-uftc8inx 7166 6 content content NN cord-010092-uftc8inx 7166 7 > > XX cord-010092-uftc8inx 7167 1 50 50 CD cord-010092-uftc8inx 7167 2 g g NN cord-010092-uftc8inx 7167 3 / / SYM cord-010092-uftc8inx 7167 4 L. L. NNP cord-010092-uftc8inx 7167 5 Residual Residual NNP cord-010092-uftc8inx 7167 6 Amotosalen Amotosalen NNP cord-010092-uftc8inx 7167 7 was be VBD cord-010092-uftc8inx 7167 8 below below IN cord-010092-uftc8inx 7167 9 2 2 CD cord-010092-uftc8inx 7167 10 lM lm NN cord-010092-uftc8inx 7167 11 in in IN cord-010092-uftc8inx 7167 12 all all DT cord-010092-uftc8inx 7167 13 post post JJ cord-010092-uftc8inx 7167 14 - - JJ cord-010092-uftc8inx 7167 15 CAD cad JJ cord-010092-uftc8inx 7167 16 samples sample NNS cord-010092-uftc8inx 7167 17 . . . cord-010092-uftc8inx 7168 1 The the DT cord-010092-uftc8inx 7168 2 concentration concentration NN cord-010092-uftc8inx 7168 3 of of IN cord-010092-uftc8inx 7168 4 TAT tat NN cord-010092-uftc8inx 7168 5 complexes complex NNS cord-010092-uftc8inx 7168 6 was be VBD cord-010092-uftc8inx 7168 7 slightly slightly RB cord-010092-uftc8inx 7168 8 reduced reduce VBN cord-010092-uftc8inx 7168 9 after after IN cord-010092-uftc8inx 7168 10 treatment treatment NN cord-010092-uftc8inx 7168 11 and and CC cord-010092-uftc8inx 7168 12 frozen frozen JJ cord-010092-uftc8inx 7168 13 storage storage NN cord-010092-uftc8inx 7168 14 . . . cord-010092-uftc8inx 7169 1 Concentrations concentration NNS cord-010092-uftc8inx 7169 2 of of IN cord-010092-uftc8inx 7169 3 C3a C3a NNP cord-010092-uftc8inx 7169 4 and and CC cord-010092-uftc8inx 7169 5 C5a C5a NNS cord-010092-uftc8inx 7169 6 were be VBD cord-010092-uftc8inx 7169 7 significantly significantly RB cord-010092-uftc8inx 7169 8 reduced reduce VBN cord-010092-uftc8inx 7169 9 with with IN cord-010092-uftc8inx 7169 10 the the DT cord-010092-uftc8inx 7169 11 CAD CAD NNP cord-010092-uftc8inx 7169 12 treatment treatment NN cord-010092-uftc8inx 7169 13 . . . cord-010092-uftc8inx 7170 1 The the DT cord-010092-uftc8inx 7170 2 plasma plasma NN cord-010092-uftc8inx 7170 3 thawing thaw VBG cord-010092-uftc8inx 7170 4 time time NN cord-010092-uftc8inx 7170 5 in in IN cord-010092-uftc8inx 7170 6 a a DT cord-010092-uftc8inx 7170 7 water water NN cord-010092-uftc8inx 7170 8 bath bath NN cord-010092-uftc8inx 7170 9 at at IN cord-010092-uftc8inx 7170 10 37 37 CD cord-010092-uftc8inx 7170 11 ° ° NN cord-010092-uftc8inx 7170 12 C C NNP cord-010092-uftc8inx 7170 13 was be VBD cord-010092-uftc8inx 7170 14 consistently consistently RB cord-010092-uftc8inx 7170 15 short short JJ cord-010092-uftc8inx 7170 16 ( ( -LRB- cord-010092-uftc8inx 7170 17 6 6 CD cord-010092-uftc8inx 7170 18 - - SYM cord-010092-uftc8inx 7170 19 7 7 CD cord-010092-uftc8inx 7170 20 min min NN cord-010092-uftc8inx 7170 21 ) ) -RRB- cord-010092-uftc8inx 7170 22 . . . cord-010092-uftc8inx 7171 1 Summary Summary NNP cord-010092-uftc8inx 7171 2 / / SYM cord-010092-uftc8inx 7171 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 7171 4 : : : cord-010092-uftc8inx 7172 1 Pathogen pathogen NN cord-010092-uftc8inx 7172 2 inactivated inactivate VBN cord-010092-uftc8inx 7172 3 plasma plasma NN cord-010092-uftc8inx 7172 4 units unit NNS cord-010092-uftc8inx 7172 5 ( ( -LRB- cord-010092-uftc8inx 7172 6 FFP FFP NNP cord-010092-uftc8inx 7172 7 - - HYPH cord-010092-uftc8inx 7172 8 A A NNP cord-010092-uftc8inx 7172 9 - - HYPH cord-010092-uftc8inx 7172 10 IBS IBS NNP cord-010092-uftc8inx 7172 11 and and CC cord-010092-uftc8inx 7172 12 FFP FFP NNP cord-010092-uftc8inx 7172 13 - - HYPH cord-010092-uftc8inx 7172 14 WB WB NNP cord-010092-uftc8inx 7172 15 - - HYPH cord-010092-uftc8inx 7172 16 IBS IBS NNP cord-010092-uftc8inx 7172 17 ) ) -RRB- cord-010092-uftc8inx 7172 18 prepared prepare VBD cord-010092-uftc8inx 7172 19 with with IN cord-010092-uftc8inx 7172 20 DEHP DEHP NNP cord-010092-uftc8inx 7172 21 free free JJ cord-010092-uftc8inx 7172 22 INTERCEPT INTERCEPT NNP cord-010092-uftc8inx 7172 23 processing processing NN cord-010092-uftc8inx 7172 24 sets set NNS cord-010092-uftc8inx 7172 25 retained retain VBN cord-010092-uftc8inx 7172 26 in in IN cord-010092-uftc8inx 7172 27 vitro vitro FW cord-010092-uftc8inx 7172 28 characteristics characteristic NNS cord-010092-uftc8inx 7172 29 which which WDT cord-010092-uftc8inx 7172 30 meet meet VBP cord-010092-uftc8inx 7172 31 the the DT cord-010092-uftc8inx 7172 32 quality quality NN cord-010092-uftc8inx 7172 33 standards standard NNS cord-010092-uftc8inx 7172 34 for for IN cord-010092-uftc8inx 7172 35 therapeutic therapeutic JJ cord-010092-uftc8inx 7172 36 plasma plasma NN cord-010092-uftc8inx 7172 37 . . . cord-010092-uftc8inx 7173 1 The the DT cord-010092-uftc8inx 7173 2 process process NN cord-010092-uftc8inx 7173 3 did do VBD cord-010092-uftc8inx 7173 4 not not RB cord-010092-uftc8inx 7173 5 activate activate VB cord-010092-uftc8inx 7173 6 coagulation coagulation NN cord-010092-uftc8inx 7173 7 or or CC cord-010092-uftc8inx 7173 8 complement complement NN cord-010092-uftc8inx 7173 9 . . . cord-010092-uftc8inx 7174 1 Reducing reduce VBG cord-010092-uftc8inx 7174 2 FFP FFP NNP cord-010092-uftc8inx 7174 3 thawing thawing NN cord-010092-uftc8inx 7174 4 time time NN cord-010092-uftc8inx 7174 5 from from IN cord-010092-uftc8inx 7174 6 routine routine JJ cord-010092-uftc8inx 7174 7 8 8 CD cord-010092-uftc8inx 7174 8 - - SYM cord-010092-uftc8inx 7174 9 10 10 CD cord-010092-uftc8inx 7174 10 to to TO cord-010092-uftc8inx 7174 11 6 6 CD cord-010092-uftc8inx 7174 12 - - SYM cord-010092-uftc8inx 7174 13 7 7 CD cord-010092-uftc8inx 7174 14 min min NN cord-010092-uftc8inx 7174 15 is be VBZ cord-010092-uftc8inx 7174 16 an an DT cord-010092-uftc8inx 7174 17 important important JJ cord-010092-uftc8inx 7174 18 benefit benefit NN cord-010092-uftc8inx 7174 19 for for IN cord-010092-uftc8inx 7174 20 emergency emergency NN cord-010092-uftc8inx 7174 21 use use NN cord-010092-uftc8inx 7174 22 . . . cord-010092-uftc8inx 7175 1 Background background NN cord-010092-uftc8inx 7175 2 : : : cord-010092-uftc8inx 7176 1 Plasma plasma NN cord-010092-uftc8inx 7176 2 coagulation coagulation NN cord-010092-uftc8inx 7176 3 factor factor NN cord-010092-uftc8inx 7176 4 concentrations concentration NNS cord-010092-uftc8inx 7176 5 usually usually RB cord-010092-uftc8inx 7176 6 differ differ VBP cord-010092-uftc8inx 7176 7 for for IN cord-010092-uftc8inx 7176 8 individual individual JJ cord-010092-uftc8inx 7176 9 donors donor NNS cord-010092-uftc8inx 7176 10 , , , cord-010092-uftc8inx 7176 11 therefore therefore RB cord-010092-uftc8inx 7176 12 pooling pool VBG cord-010092-uftc8inx 7176 13 of of IN cord-010092-uftc8inx 7176 14 whole whole JJ cord-010092-uftc8inx 7176 15 - - HYPH cord-010092-uftc8inx 7176 16 blood blood NN cord-010092-uftc8inx 7176 17 derived derive VBN cord-010092-uftc8inx 7176 18 plasma plasma NN cord-010092-uftc8inx 7176 19 units unit NNS cord-010092-uftc8inx 7176 20 moderates moderate NNS cord-010092-uftc8inx 7176 21 high high JJ cord-010092-uftc8inx 7176 22 or or CC cord-010092-uftc8inx 7176 23 low low JJ cord-010092-uftc8inx 7176 24 coagulation coagulation NN cord-010092-uftc8inx 7176 25 factor factor NN cord-010092-uftc8inx 7176 26 concentrations concentration NNS cord-010092-uftc8inx 7176 27 and and CC cord-010092-uftc8inx 7176 28 ensures ensure VBZ cord-010092-uftc8inx 7176 29 transfusion transfusion NN cord-010092-uftc8inx 7176 30 of of IN cord-010092-uftc8inx 7176 31 more more RBR cord-010092-uftc8inx 7176 32 standardized standardized JJ cord-010092-uftc8inx 7176 33 blood blood NN cord-010092-uftc8inx 7176 34 components component NNS cord-010092-uftc8inx 7176 35 . . . cord-010092-uftc8inx 7177 1 Moreover moreover RB cord-010092-uftc8inx 7177 2 , , , cord-010092-uftc8inx 7177 3 pooling pooling NN cord-010092-uftc8inx 7177 4 contributes contribute VBZ cord-010092-uftc8inx 7177 5 to to IN cord-010092-uftc8inx 7177 6 dilution dilution NN cord-010092-uftc8inx 7177 7 of of IN cord-010092-uftc8inx 7177 8 reactive reactive JJ cord-010092-uftc8inx 7177 9 antibodies antibody NNS cord-010092-uftc8inx 7177 10 and and CC cord-010092-uftc8inx 7177 11 may may MD cord-010092-uftc8inx 7177 12 reduce reduce VB cord-010092-uftc8inx 7177 13 the the DT cord-010092-uftc8inx 7177 14 risk risk NN cord-010092-uftc8inx 7177 15 of of IN cord-010092-uftc8inx 7177 16 non non JJ cord-010092-uftc8inx 7177 17 - - JJ cord-010092-uftc8inx 7177 18 hemolytic hemolytic JJ cord-010092-uftc8inx 7177 19 transfusion transfusion NN cord-010092-uftc8inx 7177 20 reactions reaction NNS cord-010092-uftc8inx 7177 21 and and CC cord-010092-uftc8inx 7177 22 TRALI TRALI NNP cord-010092-uftc8inx 7177 23 . . . cord-010092-uftc8inx 7178 1 Additionally additionally RB cord-010092-uftc8inx 7178 2 pathogen pathogen NN cord-010092-uftc8inx 7178 3 inactivation inactivation NN cord-010092-uftc8inx 7178 4 reduces reduce VBZ cord-010092-uftc8inx 7178 5 the the DT cord-010092-uftc8inx 7178 6 risk risk NN cord-010092-uftc8inx 7178 7 of of IN cord-010092-uftc8inx 7178 8 transfusion transfusion NN cord-010092-uftc8inx 7178 9 - - HYPH cord-010092-uftc8inx 7178 10 transmitted transmit VBN cord-010092-uftc8inx 7178 11 infections infection NNS cord-010092-uftc8inx 7178 12 , , , cord-010092-uftc8inx 7178 13 and and CC cord-010092-uftc8inx 7178 14 non non JJ cord-010092-uftc8inx 7178 15 - - JJ cord-010092-uftc8inx 7178 16 hemolytic hemolytic JJ cord-010092-uftc8inx 7178 17 transfusion transfusion NN cord-010092-uftc8inx 7178 18 reactions reaction NNS cord-010092-uftc8inx 7178 19 as as RB cord-010092-uftc8inx 7178 20 well well RB cord-010092-uftc8inx 7178 21 as as IN cord-010092-uftc8inx 7178 22 GvHD gvhd NN cord-010092-uftc8inx 7178 23 through through IN cord-010092-uftc8inx 7178 24 inactivation inactivation NN cord-010092-uftc8inx 7178 25 of of IN cord-010092-uftc8inx 7178 26 residual residual JJ cord-010092-uftc8inx 7178 27 lymphocytes lymphocyte NNS cord-010092-uftc8inx 7178 28 . . . cord-010092-uftc8inx 7179 1 Aims aim VBZ cord-010092-uftc8inx 7179 2 : : : cord-010092-uftc8inx 7180 1 Assessment assessment NN cord-010092-uftc8inx 7180 2 of of IN cord-010092-uftc8inx 7180 3 the the DT cord-010092-uftc8inx 7180 4 impact impact NN cord-010092-uftc8inx 7180 5 of of IN cord-010092-uftc8inx 7180 6 plasma plasma NN cord-010092-uftc8inx 7180 7 pooling pooling NN cord-010092-uftc8inx 7180 8 and and CC cord-010092-uftc8inx 7180 9 pathogen pathogen NN cord-010092-uftc8inx 7180 10 inactivation inactivation NN cord-010092-uftc8inx 7180 11 on on IN cord-010092-uftc8inx 7180 12 the the DT cord-010092-uftc8inx 7180 13 standardization standardization NN cord-010092-uftc8inx 7180 14 of of IN cord-010092-uftc8inx 7180 15 blood blood NN cord-010092-uftc8inx 7180 16 components component NNS cord-010092-uftc8inx 7180 17 and and CC cord-010092-uftc8inx 7180 18 plasma plasma NN cord-010092-uftc8inx 7180 19 quality quality NN cord-010092-uftc8inx 7180 20 . . . cord-010092-uftc8inx 7181 1 Methods method NNS cord-010092-uftc8inx 7181 2 : : : cord-010092-uftc8inx 7182 1 The the DT cord-010092-uftc8inx 7182 2 study study NN cord-010092-uftc8inx 7182 3 included include VBD cord-010092-uftc8inx 7182 4 5 5 CD cord-010092-uftc8inx 7182 5 experiments experiment NNS cord-010092-uftc8inx 7182 6 . . . cord-010092-uftc8inx 7183 1 For for IN cord-010092-uftc8inx 7183 2 each each DT cord-010092-uftc8inx 7183 3 experiment experiment NN cord-010092-uftc8inx 7183 4 5 5 CD cord-010092-uftc8inx 7183 5 male male NN cord-010092-uftc8inx 7183 6 - - HYPH cord-010092-uftc8inx 7183 7 donor donor NN cord-010092-uftc8inx 7183 8 , , , cord-010092-uftc8inx 7183 9 ABO ABO NNP cord-010092-uftc8inx 7183 10 - - HYPH cord-010092-uftc8inx 7183 11 compatible compatible JJ cord-010092-uftc8inx 7183 12 whole whole JJ cord-010092-uftc8inx 7183 13 - - HYPH cord-010092-uftc8inx 7183 14 blood blood NN cord-010092-uftc8inx 7183 15 derived derive VBN cord-010092-uftc8inx 7183 16 plasma plasma NN cord-010092-uftc8inx 7183 17 units unit NNS cord-010092-uftc8inx 7183 18 ( ( -LRB- cord-010092-uftc8inx 7183 19 ≥ ≥ CD cord-010092-uftc8inx 7183 20 270 270 CD cord-010092-uftc8inx 7183 21 ml ml NNS cord-010092-uftc8inx 7183 22 ) ) -RRB- cord-010092-uftc8inx 7183 23 were be VBD cord-010092-uftc8inx 7183 24 collected collect VBN cord-010092-uftc8inx 7183 25 from from IN cord-010092-uftc8inx 7183 26 different different JJ cord-010092-uftc8inx 7183 27 donors donor NNS cord-010092-uftc8inx 7183 28 and and CC cord-010092-uftc8inx 7183 29 pooled pool VBD cord-010092-uftc8inx 7183 30 using use VBG cord-010092-uftc8inx 7183 31 the the DT cord-010092-uftc8inx 7183 32 Donopack Donopack NNP cord-010092-uftc8inx 7183 33 Optipool Optipool NNP cord-010092-uftc8inx 7183 34 plasma plasma NN cord-010092-uftc8inx 7183 35 pooling pooling NN cord-010092-uftc8inx 7183 36 set set NN cord-010092-uftc8inx 7183 37 ( ( -LRB- cord-010092-uftc8inx 7183 38 Cerus Cerus NNP cord-010092-uftc8inx 7183 39 Europe Europe NNP cord-010092-uftc8inx 7183 40 B.V. B.V. NNP cord-010092-uftc8inx 7183 41 ) ) -RRB- cord-010092-uftc8inx 7183 42 . . . cord-010092-uftc8inx 7184 1 Each each DT cord-010092-uftc8inx 7184 2 of of IN cord-010092-uftc8inx 7184 3 the the DT cord-010092-uftc8inx 7184 4 5-unit 5-unit CD cord-010092-uftc8inx 7184 5 pools pool NNS cord-010092-uftc8inx 7184 6 were be VBD cord-010092-uftc8inx 7184 7 split split VBN cord-010092-uftc8inx 7184 8 into into IN cord-010092-uftc8inx 7184 9 2 2 CD cord-010092-uftc8inx 7184 10 equal equal JJ cord-010092-uftc8inx 7184 11 minipools minipool NNS cord-010092-uftc8inx 7184 12 which which WDT cord-010092-uftc8inx 7184 13 were be VBD cord-010092-uftc8inx 7184 14 subsequently subsequently RB cord-010092-uftc8inx 7184 15 treated treat VBN cord-010092-uftc8inx 7184 16 with with IN cord-010092-uftc8inx 7184 17 the the DT cord-010092-uftc8inx 7184 18 in in IN cord-010092-uftc8inx 7184 19 Intercept Intercept NNP cord-010092-uftc8inx 7184 20 Blood Blood NNP cord-010092-uftc8inx 7184 21 System System NNP cord-010092-uftc8inx 7184 22 ( ( -LRB- cord-010092-uftc8inx 7184 23 Cerus Cerus NNP cord-010092-uftc8inx 7184 24 Europe Europe NNP cord-010092-uftc8inx 7184 25 B.V. B.V. NNP cord-010092-uftc8inx 7184 26 ) ) -RRB- cord-010092-uftc8inx 7184 27 . . . cord-010092-uftc8inx 7185 1 Then then RB cord-010092-uftc8inx 7185 2 , , , cord-010092-uftc8inx 7185 3 each each DT cord-010092-uftc8inx 7185 4 minipool minipool NN cord-010092-uftc8inx 7185 5 was be VBD cord-010092-uftc8inx 7185 6 split split VBN cord-010092-uftc8inx 7185 7 into into IN cord-010092-uftc8inx 7185 8 3 3 CD cord-010092-uftc8inx 7185 9 ( ( -LRB- cord-010092-uftc8inx 7185 10 ≥200 ≥200 '' cord-010092-uftc8inx 7185 11 ml ml NN cord-010092-uftc8inx 7185 12 ) ) -RRB- cord-010092-uftc8inx 7185 13 therapeutic therapeutic JJ cord-010092-uftc8inx 7185 14 units unit NNS cord-010092-uftc8inx 7185 15 . . . cord-010092-uftc8inx 7186 1 Samples sample NNS cord-010092-uftc8inx 7186 2 were be VBD cord-010092-uftc8inx 7186 3 collected collect VBN cord-010092-uftc8inx 7186 4 before before RB cord-010092-uftc8inx 7186 5 and and CC cord-010092-uftc8inx 7186 6 after after IN cord-010092-uftc8inx 7186 7 pooling pool VBG cord-010092-uftc8inx 7186 8 as as RB cord-010092-uftc8inx 7186 9 well well RB cord-010092-uftc8inx 7186 10 as as IN cord-010092-uftc8inx 7186 11 after after IN cord-010092-uftc8inx 7186 12 inactivation inactivation NN cord-010092-uftc8inx 7186 13 to to TO cord-010092-uftc8inx 7186 14 assess assess VB cord-010092-uftc8inx 7186 15 the the DT cord-010092-uftc8inx 7186 16 coagulation coagulation NN cord-010092-uftc8inx 7186 17 factor factor NN cord-010092-uftc8inx 7186 18 content content NN cord-010092-uftc8inx 7186 19 ( ( -LRB- cord-010092-uftc8inx 7186 20 FVIII FVIII NNP cord-010092-uftc8inx 7186 21 , , , cord-010092-uftc8inx 7186 22 FIX fix NN cord-010092-uftc8inx 7186 23 , , , cord-010092-uftc8inx 7186 24 Fibrinogen Fibrinogen NNP cord-010092-uftc8inx 7186 25 , , , cord-010092-uftc8inx 7186 26 vWF vwf NN cord-010092-uftc8inx 7186 27 antigen antigen NN cord-010092-uftc8inx 7186 28 using use VBG cord-010092-uftc8inx 7186 29 ELISA ELISA NNP cord-010092-uftc8inx 7186 30 ) ) -RRB- cord-010092-uftc8inx 7186 31 and and CC cord-010092-uftc8inx 7186 32 coagulation coagulation NN cord-010092-uftc8inx 7186 33 time time NN cord-010092-uftc8inx 7186 34 ( ( -LRB- cord-010092-uftc8inx 7186 35 APTT APTT NNP cord-010092-uftc8inx 7186 36 , , , cord-010092-uftc8inx 7186 37 PT PT NNP cord-010092-uftc8inx 7186 38 ) ) -RRB- cord-010092-uftc8inx 7186 39 . . . cord-010092-uftc8inx 7187 1 The the DT cord-010092-uftc8inx 7187 2 study study NN cord-010092-uftc8inx 7187 3 - - HYPH cord-010092-uftc8inx 7187 4 analysis analysis NN cord-010092-uftc8inx 7187 5 included include VBD cord-010092-uftc8inx 7187 6 samples sample NNS cord-010092-uftc8inx 7187 7 from from IN cord-010092-uftc8inx 7187 8 five five CD cord-010092-uftc8inx 7187 9 pools pool NNS cord-010092-uftc8inx 7187 10 from from IN cord-010092-uftc8inx 7187 11 5 5 CD cord-010092-uftc8inx 7187 12 single single JJ cord-010092-uftc8inx 7187 13 plasma plasma NN cord-010092-uftc8inx 7187 14 units unit NNS cord-010092-uftc8inx 7187 15 respectively respectively RB cord-010092-uftc8inx 7188 1 ( ( -LRB- cord-010092-uftc8inx 7188 2 Background background NN cord-010092-uftc8inx 7188 3 : : : cord-010092-uftc8inx 7188 4 Biotin Biotin NNP cord-010092-uftc8inx 7188 5 ( ( -LRB- cord-010092-uftc8inx 7188 6 Bio Bio NNP cord-010092-uftc8inx 7188 7 ) ) -RRB- cord-010092-uftc8inx 7188 8 is be VBZ cord-010092-uftc8inx 7188 9 an an DT cord-010092-uftc8inx 7188 10 alternative alternative NN cord-010092-uftc8inx 7188 11 to to IN cord-010092-uftc8inx 7188 12 radioactive radioactive JJ cord-010092-uftc8inx 7188 13 red red JJ cord-010092-uftc8inx 7188 14 blood blood NN cord-010092-uftc8inx 7188 15 cell cell NN cord-010092-uftc8inx 7188 16 ( ( -LRB- cord-010092-uftc8inx 7188 17 RBC RBC NNP cord-010092-uftc8inx 7188 18 ) ) -RRB- cord-010092-uftc8inx 7188 19 tracers tracer NNS cord-010092-uftc8inx 7188 20 which which WDT cord-010092-uftc8inx 7188 21 allows allow VBZ cord-010092-uftc8inx 7188 22 one one PRP cord-010092-uftc8inx 7188 23 to to TO cord-010092-uftc8inx 7188 24 concurrently concurrently RB cord-010092-uftc8inx 7188 25 track track VB cord-010092-uftc8inx 7188 26 in in IN cord-010092-uftc8inx 7188 27 vivo vivo NN cord-010092-uftc8inx 7188 28 multiple multiple JJ cord-010092-uftc8inx 7188 29 cell cell NN cord-010092-uftc8inx 7188 30 populations population NNS cord-010092-uftc8inx 7188 31 labeled label VBN cord-010092-uftc8inx 7188 32 at at IN cord-010092-uftc8inx 7188 33 different different JJ cord-010092-uftc8inx 7188 34 Bio Bio NNP cord-010092-uftc8inx 7188 35 densities density NNS cord-010092-uftc8inx 7188 36 . . . cord-010092-uftc8inx 7189 1 In in IN cord-010092-uftc8inx 7189 2 American american JJ cord-010092-uftc8inx 7189 3 clinical clinical JJ cord-010092-uftc8inx 7189 4 trials trial NNS cord-010092-uftc8inx 7189 5 , , , cord-010092-uftc8inx 7189 6 multi multi JJ cord-010092-uftc8inx 7189 7 - - JJ cord-010092-uftc8inx 7189 8 labeled label VBN cord-010092-uftc8inx 7189 9 BioRBC BioRBC NNS cord-010092-uftc8inx 7189 10 have have VBP cord-010092-uftc8inx 7189 11 been be VBN cord-010092-uftc8inx 7189 12 transfused transfuse VBN cord-010092-uftc8inx 7189 13 in in IN cord-010092-uftc8inx 7189 14 man man NN cord-010092-uftc8inx 7189 15 to to TO cord-010092-uftc8inx 7189 16 assess assess VB cord-010092-uftc8inx 7189 17 their -PRON- PRP$ cord-010092-uftc8inx 7189 18 survival survival NN cord-010092-uftc8inx 7189 19 ( ( -LRB- cord-010092-uftc8inx 7189 20 Mock Mock NNP cord-010092-uftc8inx 7189 21 et et FW cord-010092-uftc8inx 7189 22 al al NNP cord-010092-uftc8inx 7189 23 , , , cord-010092-uftc8inx 7189 24 Transfusion Transfusion NNP cord-010092-uftc8inx 7189 25 , , , cord-010092-uftc8inx 7189 26 2018 2018 CD cord-010092-uftc8inx 7189 27 ) ) -RRB- cord-010092-uftc8inx 7189 28 . . . cord-010092-uftc8inx 7190 1 In in IN cord-010092-uftc8inx 7190 2 these these DT cord-010092-uftc8inx 7190 3 studies study NNS cord-010092-uftc8inx 7190 4 , , , cord-010092-uftc8inx 7190 5 the the DT cord-010092-uftc8inx 7190 6 different different JJ cord-010092-uftc8inx 7190 7 BioRBC BioRBC NNS cord-010092-uftc8inx 7190 8 populations population NNS cord-010092-uftc8inx 7190 9 were be VBD cord-010092-uftc8inx 7190 10 monitored monitor VBN cord-010092-uftc8inx 7190 11 by by IN cord-010092-uftc8inx 7190 12 ex ex FW cord-010092-uftc8inx 7190 13 vivo vivo NN cord-010092-uftc8inx 7190 14 flow flow NN cord-010092-uftc8inx 7190 15 cytometry cytometry NN cord-010092-uftc8inx 7190 16 analysis analysis NN cord-010092-uftc8inx 7190 17 using use VBG cord-010092-uftc8inx 7190 18 Streptavidin Streptavidin NNP cord-010092-uftc8inx 7190 19 . . . cord-010092-uftc8inx 7191 1 So so RB cord-010092-uftc8inx 7191 2 far far RB cord-010092-uftc8inx 7191 3 , , , cord-010092-uftc8inx 7191 4 the the DT cord-010092-uftc8inx 7191 5 biotinylation biotinylation NN cord-010092-uftc8inx 7191 6 reagents reagent NNS cord-010092-uftc8inx 7191 7 BioSulfoNHS BioSulfoNHS NNP cord-010092-uftc8inx 7191 8 was be VBD cord-010092-uftc8inx 7191 9 not not RB cord-010092-uftc8inx 7191 10 complying comply VBG cord-010092-uftc8inx 7191 11 with with IN cord-010092-uftc8inx 7191 12 good good JJ cord-010092-uftc8inx 7191 13 manufacturing manufacturing NN cord-010092-uftc8inx 7191 14 practices practice NNS cord-010092-uftc8inx 7191 15 ( ( -LRB- cord-010092-uftc8inx 7191 16 GMP GMP NNP cord-010092-uftc8inx 7191 17 ) ) -RRB- cord-010092-uftc8inx 7191 18 . . . cord-010092-uftc8inx 7192 1 Moreover moreover RB cord-010092-uftc8inx 7192 2 BioRBC BioRBC NNS cord-010092-uftc8inx 7192 3 , , , cord-010092-uftc8inx 7192 4 with with IN cord-010092-uftc8inx 7192 5 Bio Bio NNP cord-010092-uftc8inx 7192 6 ≥ ≥ NNP cord-010092-uftc8inx 7192 7 18 18 CD cord-010092-uftc8inx 7192 8 lg lg NNP cord-010092-uftc8inx 7192 9 / / SYM cord-010092-uftc8inx 7192 10 mL mL NNP cord-010092-uftc8inx 7192 11 , , , cord-010092-uftc8inx 7192 12 have have VBP cord-010092-uftc8inx 7192 13 induced induce VBN cord-010092-uftc8inx 7192 14 immunization immunization NN cord-010092-uftc8inx 7192 15 of of IN cord-010092-uftc8inx 7192 16 the the DT cord-010092-uftc8inx 7192 17 recipient recipient NN cord-010092-uftc8inx 7192 18 , , , cord-010092-uftc8inx 7192 19 in in IN cord-010092-uftc8inx 7192 20 rare rare JJ cord-010092-uftc8inx 7192 21 cases case NNS cord-010092-uftc8inx 7192 22 ( ( -LRB- cord-010092-uftc8inx 7192 23 Schmidt Schmidt NNP cord-010092-uftc8inx 7192 24 et et NNP cord-010092-uftc8inx 7192 25 al al NNP cord-010092-uftc8inx 7192 26 , , , cord-010092-uftc8inx 7192 27 Transfusion Transfusion NNP cord-010092-uftc8inx 7192 28 , , , cord-010092-uftc8inx 7192 29 2017 2017 CD cord-010092-uftc8inx 7192 30 ) ) -RRB- cord-010092-uftc8inx 7192 31 . . . cord-010092-uftc8inx 7193 1 This this DT cord-010092-uftc8inx 7193 2 represents represent VBZ cord-010092-uftc8inx 7193 3 an an DT cord-010092-uftc8inx 7193 4 obstacle obstacle NN cord-010092-uftc8inx 7193 5 regarding regard VBG cord-010092-uftc8inx 7193 6 the the DT cord-010092-uftc8inx 7193 7 regulatory regulatory JJ cord-010092-uftc8inx 7193 8 European european JJ cord-010092-uftc8inx 7193 9 authorities authority NNS cord-010092-uftc8inx 7193 10 . . . cord-010092-uftc8inx 7194 1 Aims aim VBZ cord-010092-uftc8inx 7194 2 : : : cord-010092-uftc8inx 7195 1 The the DT cord-010092-uftc8inx 7195 2 aim aim NN cord-010092-uftc8inx 7195 3 of of IN cord-010092-uftc8inx 7195 4 this this DT cord-010092-uftc8inx 7195 5 study study NN cord-010092-uftc8inx 7195 6 is be VBZ cord-010092-uftc8inx 7195 7 to to TO cord-010092-uftc8inx 7195 8 describe describe VB cord-010092-uftc8inx 7195 9 a a DT cord-010092-uftc8inx 7195 10 procedure procedure NN cord-010092-uftc8inx 7195 11 of of IN cord-010092-uftc8inx 7195 12 biotinylation biotinylation NN cord-010092-uftc8inx 7195 13 of of IN cord-010092-uftc8inx 7195 14 RBC RBC NNP cord-010092-uftc8inx 7195 15 intended intend VBN cord-010092-uftc8inx 7195 16 for for IN cord-010092-uftc8inx 7195 17 clinical clinical JJ cord-010092-uftc8inx 7195 18 trials trial NNS cord-010092-uftc8inx 7195 19 while while IN cord-010092-uftc8inx 7195 20 refining refine VBG cord-010092-uftc8inx 7195 21 the the DT cord-010092-uftc8inx 7195 22 levels level NNS cord-010092-uftc8inx 7195 23 of of IN cord-010092-uftc8inx 7195 24 Bio Bio NNP cord-010092-uftc8inx 7195 25 ≤ ≤ NNP cord-010092-uftc8inx 7195 26 18 18 CD cord-010092-uftc8inx 7195 27 lg lg NNP cord-010092-uftc8inx 7195 28 / / SYM cord-010092-uftc8inx 7195 29 mL. mL. NNS cord-010092-uftc8inx 7195 30 Methods method NNS cord-010092-uftc8inx 7195 31 : : : cord-010092-uftc8inx 7195 32 Sterile sterile JJ cord-010092-uftc8inx 7195 33 status status NN cord-010092-uftc8inx 7195 34 is be VBZ cord-010092-uftc8inx 7195 35 met meet VBN cord-010092-uftc8inx 7195 36 throughout throughout IN cord-010092-uftc8inx 7195 37 the the DT cord-010092-uftc8inx 7195 38 process process NN cord-010092-uftc8inx 7195 39 . . . cord-010092-uftc8inx 7196 1 RBC RBC NNP cord-010092-uftc8inx 7196 2 are be VBP cord-010092-uftc8inx 7196 3 taken take VBN cord-010092-uftc8inx 7196 4 from from IN cord-010092-uftc8inx 7196 5 standard standard JJ cord-010092-uftc8inx 7196 6 RBC RBC NNP cord-010092-uftc8inx 7196 7 concentrates concentrate VBZ cord-010092-uftc8inx 7196 8 and and CC cord-010092-uftc8inx 7196 9 treated treat VBN cord-010092-uftc8inx 7196 10 with with IN cord-010092-uftc8inx 7196 11 BioSulfoNHS biosulfonh NNS cord-010092-uftc8inx 7196 12 of of IN cord-010092-uftc8inx 7196 13 GMP GMP NNP cord-010092-uftc8inx 7196 14 - - HYPH cord-010092-uftc8inx 7196 15 grade grade NN cord-010092-uftc8inx 7196 16 ( ( -LRB- cord-010092-uftc8inx 7196 17 0 0 CD cord-010092-uftc8inx 7196 18 to to IN cord-010092-uftc8inx 7196 19 70 70 CD cord-010092-uftc8inx 7196 20 lg lg NN cord-010092-uftc8inx 7196 21 / / SYM cord-010092-uftc8inx 7196 22 mL mL NNP cord-010092-uftc8inx 7196 23 ) ) -RRB- cord-010092-uftc8inx 7196 24 recently recently RB cord-010092-uftc8inx 7196 25 commercialized commercialize VBN cord-010092-uftc8inx 7196 26 . . . cord-010092-uftc8inx 7197 1 Washing washing NN cord-010092-uftc8inx 7197 2 buffer buffer NN cord-010092-uftc8inx 7197 3 is be VBZ cord-010092-uftc8inx 7197 4 of of IN cord-010092-uftc8inx 7197 5 injectable injectable JJ cord-010092-uftc8inx 7197 6 - - HYPH cord-010092-uftc8inx 7197 7 grade grade NN cord-010092-uftc8inx 7197 8 . . . cord-010092-uftc8inx 7198 1 Biotinylation biotinylation NN cord-010092-uftc8inx 7198 2 efficacy efficacy NN cord-010092-uftc8inx 7198 3 is be VBZ cord-010092-uftc8inx 7198 4 controlled control VBN cord-010092-uftc8inx 7198 5 by by IN cord-010092-uftc8inx 7198 6 flow flow NN cord-010092-uftc8inx 7198 7 cytometry cytometry NN cord-010092-uftc8inx 7198 8 with with IN cord-010092-uftc8inx 7198 9 streptavidin streptavidin NNS cord-010092-uftc8inx 7198 10 conjugated conjugate VBN cord-010092-uftc8inx 7198 11 to to IN cord-010092-uftc8inx 7198 12 2 2 CD cord-010092-uftc8inx 7198 13 different different JJ cord-010092-uftc8inx 7198 14 fluorochromes fluorochrome NNS cord-010092-uftc8inx 7198 15 : : : cord-010092-uftc8inx 7198 16 phycoerythrin phycoerythrin NNP cord-010092-uftc8inx 7198 17 ( ( -LRB- cord-010092-uftc8inx 7198 18 PE PE NNP cord-010092-uftc8inx 7198 19 ) ) -RRB- cord-010092-uftc8inx 7198 20 or or CC cord-010092-uftc8inx 7198 21 brilliant brilliant JJ cord-010092-uftc8inx 7198 22 violet violet NN cord-010092-uftc8inx 7198 23 ( ( -LRB- cord-010092-uftc8inx 7198 24 BV421 BV421 NNP cord-010092-uftc8inx 7198 25 ) ) -RRB- cord-010092-uftc8inx 7198 26 . . . cord-010092-uftc8inx 7199 1 Results result NNS cord-010092-uftc8inx 7199 2 : : : cord-010092-uftc8inx 7199 3 Labeling label VBG cord-010092-uftc8inx 7199 4 with with IN cord-010092-uftc8inx 7199 5 BioSulfoNHS biosulfonh NNS cord-010092-uftc8inx 7199 6 of of IN cord-010092-uftc8inx 7199 7 GMP GMP NNP cord-010092-uftc8inx 7199 8 - - HYPH cord-010092-uftc8inx 7199 9 grade grade NN cord-010092-uftc8inx 7199 10 or or CC cord-010092-uftc8inx 7199 11 non non JJ cord-010092-uftc8inx 7199 12 GMP GMP NNP cord-010092-uftc8inx 7199 13 - - HYPH cord-010092-uftc8inx 7199 14 grade grade NN cord-010092-uftc8inx 7199 15 is be VBZ cord-010092-uftc8inx 7199 16 comparable comparable JJ cord-010092-uftc8inx 7199 17 and and CC cord-010092-uftc8inx 7199 18 4 4 CD cord-010092-uftc8inx 7199 19 populations population NNS cord-010092-uftc8inx 7199 20 of of IN cord-010092-uftc8inx 7199 21 RBC RBC NNP cord-010092-uftc8inx 7199 22 could could MD cord-010092-uftc8inx 7199 23 be be VB cord-010092-uftc8inx 7199 24 easily easily RB cord-010092-uftc8inx 7199 25 distinguished distinguish VBN cord-010092-uftc8inx 7199 26 between between IN cord-010092-uftc8inx 7199 27 themselves -PRON- PRP cord-010092-uftc8inx 7199 28 and and CC cord-010092-uftc8inx 7199 29 from from IN cord-010092-uftc8inx 7199 30 unlabeled unlabeled JJ cord-010092-uftc8inx 7199 31 blood blood NN cord-010092-uftc8inx 7199 32 cells cell NNS cord-010092-uftc8inx 7199 33 . . . cord-010092-uftc8inx 7200 1 BioSulfoNHS BioSulfoNHS NNP cord-010092-uftc8inx 7201 1 ( ( -LRB- cord-010092-uftc8inx 7201 2 lg lg NNP cord-010092-uftc8inx 7201 3 / / SYM cord-010092-uftc8inx 7201 4 mL mL NNP cord-010092-uftc8inx 7201 5 ) ) -RRB- cord-010092-uftc8inx 7201 6 : : : cord-010092-uftc8inx 7201 7 0 0 NFP cord-010092-uftc8inx 7201 8 ( ( -LRB- cord-010092-uftc8inx 7201 9 MFI MFI NNP cord-010092-uftc8inx 7201 10 0.4 0.4 CD cord-010092-uftc8inx 7201 11 ) ) -RRB- cord-010092-uftc8inx 7201 12 , , , cord-010092-uftc8inx 7201 13 4 4 CD cord-010092-uftc8inx 7201 14 ( ( -LRB- cord-010092-uftc8inx 7201 15 GMP GMP NNP cord-010092-uftc8inx 7201 16 MFI MFI NNP cord-010092-uftc8inx 7201 17 12 12 CD cord-010092-uftc8inx 7201 18 ; ; : cord-010092-uftc8inx 7201 19 non non JJ cord-010092-uftc8inx 7201 20 GMP GMP NNP cord-010092-uftc8inx 7201 21 MFI MFI NNP cord-010092-uftc8inx 7201 22 9.5 9.5 CD cord-010092-uftc8inx 7201 23 ) ) -RRB- cord-010092-uftc8inx 7201 24 , , , cord-010092-uftc8inx 7201 25 18 18 CD cord-010092-uftc8inx 7201 26 ( ( -LRB- cord-010092-uftc8inx 7201 27 GMP GMP NNP cord-010092-uftc8inx 7201 28 MFI MFI NNP cord-010092-uftc8inx 7201 29 44 44 CD cord-010092-uftc8inx 7201 30 ; ; : cord-010092-uftc8inx 7201 31 non non JJ cord-010092-uftc8inx 7201 32 GMP GMP NNP cord-010092-uftc8inx 7201 33 MFI MFI NNP cord-010092-uftc8inx 7201 34 42 42 CD cord-010092-uftc8inx 7201 35 ) ) -RRB- cord-010092-uftc8inx 7201 36 , , , cord-010092-uftc8inx 7201 37 70 70 CD cord-010092-uftc8inx 7201 38 ( ( -LRB- cord-010092-uftc8inx 7201 39 GMP GMP NNP cord-010092-uftc8inx 7201 40 MFI MFI NNP cord-010092-uftc8inx 7201 41 174 174 CD cord-010092-uftc8inx 7201 42 ; ; : cord-010092-uftc8inx 7201 43 non non JJ cord-010092-uftc8inx 7201 44 GMP GMP NNP cord-010092-uftc8inx 7201 45 MFI MFI NNP cord-010092-uftc8inx 7201 46 180 180 CD cord-010092-uftc8inx 7201 47 ) ) -RRB- cord-010092-uftc8inx 7201 48 . . . cord-010092-uftc8inx 7202 1 Streptavidin Streptavidin NNP cord-010092-uftc8inx 7202 2 - - HYPH cord-010092-uftc8inx 7202 3 BV421 BV421 NNP cord-010092-uftc8inx 7202 4 brighter bright JJR cord-010092-uftc8inx 7202 5 than than IN cord-010092-uftc8inx 7202 6 Streptavidin Streptavidin NNP cord-010092-uftc8inx 7202 7 - - HYPH cord-010092-uftc8inx 7202 8 PE PE NNP cord-010092-uftc8inx 7202 9 is be VBZ cord-010092-uftc8inx 7202 10 a a DT cord-010092-uftc8inx 7202 11 promising promising JJ cord-010092-uftc8inx 7202 12 tool tool NN cord-010092-uftc8inx 7202 13 because because IN cord-010092-uftc8inx 7202 14 it -PRON- PRP cord-010092-uftc8inx 7202 15 amplifies amplify VBZ cord-010092-uftc8inx 7202 16 by by IN cord-010092-uftc8inx 7202 17 1.7 1.7 CD cord-010092-uftc8inx 7202 18 the the DT cord-010092-uftc8inx 7202 19 signal signal NN cord-010092-uftc8inx 7202 20 of of IN cord-010092-uftc8inx 7202 21 fluorescence fluorescence NN cord-010092-uftc8inx 7202 22 and and CC cord-010092-uftc8inx 7202 23 allows allow VBZ cord-010092-uftc8inx 7202 24 a a DT cord-010092-uftc8inx 7202 25 good good JJ cord-010092-uftc8inx 7202 26 differentiation differentiation NN cord-010092-uftc8inx 7202 27 of of IN cord-010092-uftc8inx 7202 28 the the DT cord-010092-uftc8inx 7202 29 4 4 CD cord-010092-uftc8inx 7202 30 populations population NNS cord-010092-uftc8inx 7202 31 of of IN cord-010092-uftc8inx 7202 32 RBC RBC NNP cord-010092-uftc8inx 7202 33 treated treat VBN cord-010092-uftc8inx 7202 34 with with IN cord-010092-uftc8inx 7202 35 only only RB cord-010092-uftc8inx 7202 36 0 0 CD cord-010092-uftc8inx 7202 37 , , , cord-010092-uftc8inx 7202 38 1 1 CD cord-010092-uftc8inx 7202 39 , , , cord-010092-uftc8inx 7202 40 4 4 CD cord-010092-uftc8inx 7202 41 and and CC cord-010092-uftc8inx 7202 42 18 18 CD cord-010092-uftc8inx 7202 43 lg lg NNP cord-010092-uftc8inx 7202 44 / / SYM cord-010092-uftc8inx 7202 45 mL mL NNP cord-010092-uftc8inx 7202 46 BioSulfoNHS BioSulfoNHS NNP cord-010092-uftc8inx 7202 47 . . . cord-010092-uftc8inx 7203 1 Summary Summary NNP cord-010092-uftc8inx 7203 2 / / SYM cord-010092-uftc8inx 7203 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 7203 4 : : : cord-010092-uftc8inx 7204 1 This this DT cord-010092-uftc8inx 7204 2 preliminary preliminary JJ cord-010092-uftc8inx 7204 3 study study NN cord-010092-uftc8inx 7204 4 explores explore VBZ cord-010092-uftc8inx 7204 5 the the DT cord-010092-uftc8inx 7204 6 feasibility feasibility NN cord-010092-uftc8inx 7204 7 of of IN cord-010092-uftc8inx 7204 8 multilabeled multilabele VBN cord-010092-uftc8inx 7204 9 BioRBC BioRBC NNP cord-010092-uftc8inx 7204 10 production production NN cord-010092-uftc8inx 7204 11 for for IN cord-010092-uftc8inx 7204 12 clinical clinical JJ cord-010092-uftc8inx 7204 13 trials trial NNS cord-010092-uftc8inx 7204 14 . . . cord-010092-uftc8inx 7205 1 The the DT cord-010092-uftc8inx 7205 2 benefits benefit NNS cord-010092-uftc8inx 7205 3 of of IN cord-010092-uftc8inx 7205 4 this this DT cord-010092-uftc8inx 7205 5 approach approach NN cord-010092-uftc8inx 7205 6 are be VBP cord-010092-uftc8inx 7205 7 to to TO cord-010092-uftc8inx 7205 8 overcome overcome VB cord-010092-uftc8inx 7205 9 the the DT cord-010092-uftc8inx 7205 10 need need NN cord-010092-uftc8inx 7205 11 for for IN cord-010092-uftc8inx 7205 12 non non JJ cord-010092-uftc8inx 7205 13 - - JJ cord-010092-uftc8inx 7205 14 radioactive radioactive JJ cord-010092-uftc8inx 7205 15 tracers tracer NNS cord-010092-uftc8inx 7205 16 , , , cord-010092-uftc8inx 7205 17 to to TO cord-010092-uftc8inx 7205 18 follow follow VB cord-010092-uftc8inx 7205 19 simultaneously simultaneously RB cord-010092-uftc8inx 7205 20 various various JJ cord-010092-uftc8inx 7205 21 populations population NNS cord-010092-uftc8inx 7205 22 of of IN cord-010092-uftc8inx 7205 23 RBC RBC NNP cord-010092-uftc8inx 7205 24 and and CC cord-010092-uftc8inx 7205 25 consequently consequently RB cord-010092-uftc8inx 7205 26 to to TO cord-010092-uftc8inx 7205 27 limit limit VB cord-010092-uftc8inx 7205 28 the the DT cord-010092-uftc8inx 7205 29 number number NN cord-010092-uftc8inx 7205 30 of of IN cord-010092-uftc8inx 7205 31 volunteers volunteer NNS cord-010092-uftc8inx 7205 32 , , , cord-010092-uftc8inx 7205 33 and and CC cord-010092-uftc8inx 7205 34 to to TO cord-010092-uftc8inx 7205 35 reduce reduce VB cord-010092-uftc8inx 7205 36 the the DT cord-010092-uftc8inx 7205 37 risk risk NN cord-010092-uftc8inx 7205 38 of of IN cord-010092-uftc8inx 7205 39 immunization immunization NN cord-010092-uftc8inx 7205 40 using use VBG cord-010092-uftc8inx 7205 41 Bio Bio NNP cord-010092-uftc8inx 7205 42 ≤ ≤ NNP cord-010092-uftc8inx 7205 43 18 18 CD cord-010092-uftc8inx 7206 1 lg lg NNP cord-010092-uftc8inx 7206 2 / / SYM cord-010092-uftc8inx 7206 3 mL. mL. NNP cord-010092-uftc8inx 7206 4 Background Background NNP cord-010092-uftc8inx 7206 5 : : : cord-010092-uftc8inx 7206 6 Rejuvenation rejuvenation NN cord-010092-uftc8inx 7206 7 is be VBZ cord-010092-uftc8inx 7206 8 aiming aim VBG cord-010092-uftc8inx 7206 9 to to TO cord-010092-uftc8inx 7206 10 revert revert VB cord-010092-uftc8inx 7206 11 ageing age VBG cord-010092-uftc8inx 7206 12 - - HYPH cord-010092-uftc8inx 7206 13 related relate VBN cord-010092-uftc8inx 7206 14 disease disease NN cord-010092-uftc8inx 7206 15 development development NN cord-010092-uftc8inx 7206 16 . . . cord-010092-uftc8inx 7207 1 Heterochronic Heterochronic NNP cord-010092-uftc8inx 7207 2 parabiosis parabiosis NN cord-010092-uftc8inx 7207 3 studies study NNS cord-010092-uftc8inx 7207 4 revealed reveal VBD cord-010092-uftc8inx 7207 5 eotaxin eotaxin NNP cord-010092-uftc8inx 7207 6 in in IN cord-010092-uftc8inx 7207 7 young young JJ cord-010092-uftc8inx 7207 8 and and CC cord-010092-uftc8inx 7207 9 old old JJ cord-010092-uftc8inx 7207 10 murine murine JJ cord-010092-uftc8inx 7207 11 blood blood NN cord-010092-uftc8inx 7207 12 as as IN cord-010092-uftc8inx 7207 13 a a DT cord-010092-uftc8inx 7207 14 regulator regulator NN cord-010092-uftc8inx 7207 15 of of IN cord-010092-uftc8inx 7207 16 brain brain NN cord-010092-uftc8inx 7207 17 aging aging NN cord-010092-uftc8inx 7207 18 and and CC cord-010092-uftc8inx 7207 19 neurogenesis neurogenesis NN cord-010092-uftc8inx 7207 20 . . . cord-010092-uftc8inx 7208 1 Umbilical umbilical JJ cord-010092-uftc8inx 7208 2 cord cord NN cord-010092-uftc8inx 7208 3 blood blood NN cord-010092-uftc8inx 7208 4 ( ( -LRB- cord-010092-uftc8inx 7208 5 UCB)-borne ucb)-borne JJ cord-010092-uftc8inx 7208 6 factors factor NNS cord-010092-uftc8inx 7208 7 including include VBG cord-010092-uftc8inx 7208 8 tissue tissue NN cord-010092-uftc8inx 7208 9 inhibitor inhibitor NN cord-010092-uftc8inx 7208 10 of of IN cord-010092-uftc8inx 7208 11 metalloproteinases metalloproteinase NNS cord-010092-uftc8inx 7208 12 2 2 CD cord-010092-uftc8inx 7209 1 ( ( -LRB- cord-010092-uftc8inx 7209 2 TIMP2 TIMP2 NNP cord-010092-uftc8inx 7209 3 ) ) -RRB- cord-010092-uftc8inx 7209 4 and and CC cord-010092-uftc8inx 7209 5 neonatal neonatal JJ cord-010092-uftc8inx 7209 6 immune immune JJ cord-010092-uftc8inx 7209 7 cells cell NNS cord-010092-uftc8inx 7209 8 also also RB cord-010092-uftc8inx 7209 9 contributed contribute VBD cord-010092-uftc8inx 7209 10 to to IN cord-010092-uftc8inx 7209 11 rejuvenation rejuvenation NN cord-010092-uftc8inx 7209 12 in in IN cord-010092-uftc8inx 7209 13 animal animal NN cord-010092-uftc8inx 7209 14 models model NNS cord-010092-uftc8inx 7209 15 . . . cord-010092-uftc8inx 7210 1 Human human JJ cord-010092-uftc8inx 7210 2 platelet platelet NN cord-010092-uftc8inx 7210 3 lysate lysate NN cord-010092-uftc8inx 7210 4 ( ( -LRB- cord-010092-uftc8inx 7210 5 HPL HPL NNP cord-010092-uftc8inx 7210 6 ) ) -RRB- cord-010092-uftc8inx 7210 7 is be VBZ cord-010092-uftc8inx 7210 8 commonly commonly RB cord-010092-uftc8inx 7210 9 used use VBN cord-010092-uftc8inx 7210 10 by by IN cord-010092-uftc8inx 7210 11 us -PRON- PRP cord-010092-uftc8inx 7210 12 and and CC cord-010092-uftc8inx 7210 13 others other NNS cord-010092-uftc8inx 7210 14 for for IN cord-010092-uftc8inx 7210 15 highly highly RB cord-010092-uftc8inx 7210 16 efficient efficient JJ cord-010092-uftc8inx 7210 17 cell cell NN cord-010092-uftc8inx 7210 18 propagation propagation NN cord-010092-uftc8inx 7210 19 in in IN cord-010092-uftc8inx 7210 20 vitro vitro FW cord-010092-uftc8inx 7211 1 ( ( -LRB- cord-010092-uftc8inx 7211 2 Burnouf Burnouf NNP cord-010092-uftc8inx 7211 3 et et NNP cord-010092-uftc8inx 7211 4 al al NNP cord-010092-uftc8inx 7211 5 . . NNP cord-010092-uftc8inx 7211 6 , , , cord-010092-uftc8inx 7211 7 Biomaterials Biomaterials NNPS cord-010092-uftc8inx 7211 8 , , , cord-010092-uftc8inx 7211 9 2016 2016 CD cord-010092-uftc8inx 7211 10 ) ) -RRB- cord-010092-uftc8inx 7211 11 . . . cord-010092-uftc8inx 7212 1 Published publish VBN cord-010092-uftc8inx 7212 2 data datum NNS cord-010092-uftc8inx 7212 3 indicate indicate VBP cord-010092-uftc8inx 7212 4 only only RB cord-010092-uftc8inx 7212 5 limited limited JJ cord-010092-uftc8inx 7212 6 differences difference NNS cord-010092-uftc8inx 7212 7 between between IN cord-010092-uftc8inx 7212 8 adult adult NN cord-010092-uftc8inx 7212 9 and and CC cord-010092-uftc8inx 7212 10 UCB UCB NNP cord-010092-uftc8inx 7212 11 - - HYPH cord-010092-uftc8inx 7212 12 derived derive VBN cord-010092-uftc8inx 7212 13 HPL HPL NNP cord-010092-uftc8inx 7212 14 , , , cord-010092-uftc8inx 7212 15 partly partly RB cord-010092-uftc8inx 7212 16 questioning question VBG cord-010092-uftc8inx 7212 17 enigmatic enigmatic JJ cord-010092-uftc8inx 7212 18 rejuvenation rejuvenation NN cord-010092-uftc8inx 7212 19 effects effect NNS cord-010092-uftc8inx 7212 20 . . . cord-010092-uftc8inx 7213 1 Aims aim VBZ cord-010092-uftc8inx 7213 2 : : : cord-010092-uftc8inx 7214 1 To to TO cord-010092-uftc8inx 7214 2 verify verify VB cord-010092-uftc8inx 7214 3 candidate candidate NN cord-010092-uftc8inx 7214 4 regenerative regenerative JJ cord-010092-uftc8inx 7214 5 factors factor NNS cord-010092-uftc8inx 7214 6 in in IN cord-010092-uftc8inx 7214 7 neonatal neonatal JJ cord-010092-uftc8inx 7214 8 blood blood NN cord-010092-uftc8inx 7214 9 products product NNS cord-010092-uftc8inx 7214 10 we -PRON- PRP cord-010092-uftc8inx 7214 11 compared compare VBD cord-010092-uftc8inx 7214 12 protein protein NN cord-010092-uftc8inx 7214 13 contents content NNS cord-010092-uftc8inx 7214 14 of of IN cord-010092-uftc8inx 7214 15 neonatal neonatal JJ cord-010092-uftc8inx 7214 16 and and CC cord-010092-uftc8inx 7214 17 adult adult NN cord-010092-uftc8inx 7214 18 plasma plasma NN cord-010092-uftc8inx 7214 19 and and CC cord-010092-uftc8inx 7214 20 platelets platelet NNS cord-010092-uftc8inx 7214 21 , , , cord-010092-uftc8inx 7214 22 respectively respectively RB cord-010092-uftc8inx 7214 23 . . . cord-010092-uftc8inx 7215 1 Methods method NNS cord-010092-uftc8inx 7215 2 : : : cord-010092-uftc8inx 7216 1 Heparinized Heparinized NNP cord-010092-uftc8inx 7216 2 UCB UCB NNP cord-010092-uftc8inx 7216 3 samples sample NNS cord-010092-uftc8inx 7216 4 ( ( -LRB- cord-010092-uftc8inx 7216 5 n n NN cord-010092-uftc8inx 7216 6 = = SYM cord-010092-uftc8inx 7216 7 9 9 CD cord-010092-uftc8inx 7216 8 ) ) -RRB- cord-010092-uftc8inx 7216 9 were be VBD cord-010092-uftc8inx 7216 10 centrifuged centrifuge VBN cord-010092-uftc8inx 7216 11 within within IN cord-010092-uftc8inx 7216 12 3 3 CD cord-010092-uftc8inx 7216 13 h h NN cord-010092-uftc8inx 7216 14 to to TO cord-010092-uftc8inx 7216 15 collect collect VB cord-010092-uftc8inx 7216 16 neonatal neonatal JJ cord-010092-uftc8inx 7216 17 platelet platelet NN cord-010092-uftc8inx 7216 18 rich rich JJ cord-010092-uftc8inx 7216 19 plasma plasma NN cord-010092-uftc8inx 7216 20 . . . cord-010092-uftc8inx 7217 1 Aliquots aliquot NNS cord-010092-uftc8inx 7217 2 from from IN cord-010092-uftc8inx 7217 3 apheresis apheresis NN cord-010092-uftc8inx 7217 4 platelet platelet NN cord-010092-uftc8inx 7217 5 concentrates concentrate VBZ cord-010092-uftc8inx 7217 6 ( ( -LRB- cord-010092-uftc8inx 7217 7 n n NN cord-010092-uftc8inx 7217 8 = = SYM cord-010092-uftc8inx 7217 9 9 9 CD cord-010092-uftc8inx 7217 10 ) ) -RRB- cord-010092-uftc8inx 7217 11 were be VBD cord-010092-uftc8inx 7217 12 used use VBN cord-010092-uftc8inx 7217 13 as as IN cord-010092-uftc8inx 7217 14 adult adult NN cord-010092-uftc8inx 7217 15 counterpart counterpart NN cord-010092-uftc8inx 7217 16 . . . cord-010092-uftc8inx 7218 1 Platelet platelet NN cord-010092-uftc8inx 7218 2 concentration concentration NN cord-010092-uftc8inx 7218 3 was be VBD cord-010092-uftc8inx 7218 4 adjusted adjust VBN cord-010092-uftc8inx 7218 5 to to IN cord-010092-uftc8inx 7218 6 7 7 CD cord-010092-uftc8inx 7218 7 - - SYM cord-010092-uftc8inx 7218 8 10 10 CD cord-010092-uftc8inx 7218 9 9 9 CD cord-010092-uftc8inx 7218 10 10 10 CD cord-010092-uftc8inx 7218 11 11 11 CD cord-010092-uftc8inx 7218 12 / / SYM cord-010092-uftc8inx 7218 13 L. L. NNP cord-010092-uftc8inx 7218 14 Plasma Plasma NNP cord-010092-uftc8inx 7218 15 supernatants supernatant NNS cord-010092-uftc8inx 7218 16 and and CC cord-010092-uftc8inx 7218 17 platelets platelet NNS cord-010092-uftc8inx 7218 18 were be VBD cord-010092-uftc8inx 7218 19 obtained obtain VBN cord-010092-uftc8inx 7218 20 by by IN cord-010092-uftc8inx 7218 21 centrifugation centrifugation NN cord-010092-uftc8inx 7218 22 and and CC cord-010092-uftc8inx 7218 23 platelet platelet NN cord-010092-uftc8inx 7218 24 pellets pellet NNS cord-010092-uftc8inx 7218 25 were be VBD cord-010092-uftc8inx 7218 26 re re VBN cord-010092-uftc8inx 7218 27 - - VBN cord-010092-uftc8inx 7218 28 suspended suspend VBN cord-010092-uftc8inx 7218 29 in in IN cord-010092-uftc8inx 7218 30 saline saline NN cord-010092-uftc8inx 7218 31 . . . cord-010092-uftc8inx 7219 1 After after IN cord-010092-uftc8inx 7219 2 two two CD cord-010092-uftc8inx 7219 3 freeze freeze NN cord-010092-uftc8inx 7219 4 / / SYM cord-010092-uftc8inx 7219 5 thaw thaw VB cord-010092-uftc8inx 7219 6 cycles cycle NNS cord-010092-uftc8inx 7219 7 at at IN cord-010092-uftc8inx 7219 8 À30 À30 NNP cord-010092-uftc8inx 7219 9 ° ° NN cord-010092-uftc8inx 7219 10 C/37 c/37 NN cord-010092-uftc8inx 7219 11 ° ° NN cord-010092-uftc8inx 7219 12 C c NN cord-010092-uftc8inx 7219 13 for for IN cord-010092-uftc8inx 7219 14 platelet platelet NN cord-010092-uftc8inx 7219 15 lysis lysis NN cord-010092-uftc8inx 7219 16 ( ( -LRB- cord-010092-uftc8inx 7219 17 nPL nPL NNP cord-010092-uftc8inx 7219 18 ; ; : cord-010092-uftc8inx 7219 19 aPL aPL NNP cord-010092-uftc8inx 7219 20 ) ) -RRB- cord-010092-uftc8inx 7220 1 the the DT cord-010092-uftc8inx 7220 2 platelet platelet NN cord-010092-uftc8inx 7220 3 fragments fragment NNS cord-010092-uftc8inx 7220 4 were be VBD cord-010092-uftc8inx 7220 5 removed remove VBN cord-010092-uftc8inx 7220 6 by by IN cord-010092-uftc8inx 7220 7 centrifugation centrifugation NN cord-010092-uftc8inx 7220 8 . . . cord-010092-uftc8inx 7221 1 The the DT cord-010092-uftc8inx 7221 2 protein protein NN cord-010092-uftc8inx 7221 3 content content NN cord-010092-uftc8inx 7221 4 was be VBD cord-010092-uftc8inx 7221 5 analyzed analyze VBN cord-010092-uftc8inx 7221 6 with with IN cord-010092-uftc8inx 7221 7 a a DT cord-010092-uftc8inx 7221 8 Proteome Proteome NNP cord-010092-uftc8inx 7221 9 Profiler profiler NN cord-010092-uftc8inx 7221 10 TM TM NNP cord-010092-uftc8inx 7221 11 Array Array NNP cord-010092-uftc8inx 7221 12 . . . cord-010092-uftc8inx 7222 1 Nine nine CD cord-010092-uftc8inx 7222 2 samples sample NNS cord-010092-uftc8inx 7222 3 of of IN cord-010092-uftc8inx 7222 4 each each DT cord-010092-uftc8inx 7222 5 group group NN cord-010092-uftc8inx 7222 6 were be VBD cord-010092-uftc8inx 7222 7 pooled pool VBN cord-010092-uftc8inx 7222 8 to to TO cord-010092-uftc8inx 7222 9 avoid avoid VB cord-010092-uftc8inx 7222 10 individual individual JJ cord-010092-uftc8inx 7222 11 donor donor NN cord-010092-uftc8inx 7222 12 variations variation NNS cord-010092-uftc8inx 7222 13 . . . cord-010092-uftc8inx 7223 1 A a DT cord-010092-uftc8inx 7223 2 threshold threshold NN cord-010092-uftc8inx 7223 3 of of IN cord-010092-uftc8inx 7223 4 50,000 50,000 CD cord-010092-uftc8inx 7223 5 AU AU NNP cord-010092-uftc8inx 7223 6 spot spot NN cord-010092-uftc8inx 7223 7 density density NN cord-010092-uftc8inx 7223 8 was be VBD cord-010092-uftc8inx 7223 9 defined define VBN cord-010092-uftc8inx 7223 10 as as IN cord-010092-uftc8inx 7223 11 cut cut VBN cord-010092-uftc8inx 7223 12 - - HYPH cord-010092-uftc8inx 7223 13 off off NN cord-010092-uftc8inx 7223 14 . . . cord-010092-uftc8inx 7224 1 Data datum NNS cord-010092-uftc8inx 7224 2 were be VBD cord-010092-uftc8inx 7224 3 analyzed analyze VBN cord-010092-uftc8inx 7224 4 by by IN cord-010092-uftc8inx 7224 5 GraphPad GraphPad NNP cord-010092-uftc8inx 7224 6 Prism Prism NNP cord-010092-uftc8inx 7224 7 8 8 CD cord-010092-uftc8inx 7224 8 using use VBG cord-010092-uftc8inx 7224 9 two two CD cord-010092-uftc8inx 7224 10 - - HYPH cord-010092-uftc8inx 7224 11 way way NN cord-010092-uftc8inx 7224 12 ANOVA ANOVA NNP cord-010092-uftc8inx 7224 13 . . . cord-010092-uftc8inx 7225 1 Results result NNS cord-010092-uftc8inx 7225 2 : : : cord-010092-uftc8inx 7226 1 Semi semi JJ cord-010092-uftc8inx 7226 2 - - JJ cord-010092-uftc8inx 7226 3 quantitative quantitative JJ cord-010092-uftc8inx 7226 4 evaluation evaluation NN cord-010092-uftc8inx 7226 5 of of IN cord-010092-uftc8inx 7226 6 105 105 CD cord-010092-uftc8inx 7226 7 analytes analyte NNS cord-010092-uftc8inx 7226 8 per per IN cord-010092-uftc8inx 7226 9 array array NN cord-010092-uftc8inx 7226 10 revealed reveal VBD cord-010092-uftc8inx 7226 11 significant significant JJ cord-010092-uftc8inx 7226 12 differences difference NNS cord-010092-uftc8inx 7226 13 . . . cord-010092-uftc8inx 7227 1 In in IN cord-010092-uftc8inx 7227 2 plasma plasma NN cord-010092-uftc8inx 7227 3 samples sample NNS cord-010092-uftc8inx 7227 4 and and CC cord-010092-uftc8inx 7227 5 platelets platelet NNS cord-010092-uftc8inx 7227 6 63 63 CD cord-010092-uftc8inx 7227 7 and and CC cord-010092-uftc8inx 7227 8 48 48 CD cord-010092-uftc8inx 7227 9 analytes analyte NNS cord-010092-uftc8inx 7227 10 were be VBD cord-010092-uftc8inx 7227 11 detected detect VBN cord-010092-uftc8inx 7227 12 above above IN cord-010092-uftc8inx 7227 13 cut cut VBN cord-010092-uftc8inx 7227 14 - - HYPH cord-010092-uftc8inx 7227 15 off off NN cord-010092-uftc8inx 7227 16 , , , cord-010092-uftc8inx 7227 17 respectively respectively RB cord-010092-uftc8inx 7227 18 . . . cord-010092-uftc8inx 7228 1 In in IN cord-010092-uftc8inx 7228 2 neonatal neonatal JJ cord-010092-uftc8inx 7228 3 plasma plasma NN cord-010092-uftc8inx 7228 4 we -PRON- PRP cord-010092-uftc8inx 7228 5 found find VBD cord-010092-uftc8inx 7228 6 more more RBR cord-010092-uftc8inx 7228 7 highly highly RB cord-010092-uftc8inx 7228 8 prevalent prevalent JJ cord-010092-uftc8inx 7228 9 proteins protein NNS cord-010092-uftc8inx 7228 10 ( ( -LRB- cord-010092-uftc8inx 7228 11 > > NFP cord-010092-uftc8inx 7228 12 200,000 200,000 CD cord-010092-uftc8inx 7228 13 AU AU NNP cord-010092-uftc8inx 7228 14 spot spot NN cord-010092-uftc8inx 7228 15 density density NN cord-010092-uftc8inx 7228 16 ) ) -RRB- cord-010092-uftc8inx 7228 17 compared compare VBN cord-010092-uftc8inx 7228 18 to to IN cord-010092-uftc8inx 7228 19 adult adult NN cord-010092-uftc8inx 7228 20 plasma plasma NN cord-010092-uftc8inx 7228 21 ( ( -LRB- cord-010092-uftc8inx 7228 22 6/63 6/63 CD cord-010092-uftc8inx 7228 23 vs. vs. IN cord-010092-uftc8inx 7228 24 3/63 3/63 CD cord-010092-uftc8inx 7228 25 ) ) -RRB- cord-010092-uftc8inx 7228 26 . . . cord-010092-uftc8inx 7229 1 Thirteen thirteen CD cord-010092-uftc8inx 7229 2 proteins protein NNS cord-010092-uftc8inx 7229 3 were be VBD cord-010092-uftc8inx 7229 4 significantly significantly RB cord-010092-uftc8inx 7229 5 elevated elevate VBN cord-010092-uftc8inx 7229 6 in in IN cord-010092-uftc8inx 7229 7 neonatal neonatal JJ cord-010092-uftc8inx 7229 8 plasma plasma NN cord-010092-uftc8inx 7229 9 including include VBG cord-010092-uftc8inx 7229 10 growth growth NN cord-010092-uftc8inx 7229 11 / / SYM cord-010092-uftc8inx 7229 12 differentiation differentiation NN cord-010092-uftc8inx 7229 13 factor factor NN cord-010092-uftc8inx 7229 14 15 15 CD cord-010092-uftc8inx 7230 1 ( ( -LRB- cord-010092-uftc8inx 7230 2 GDF GDF NNP cord-010092-uftc8inx 7230 3 15 15 CD cord-010092-uftc8inx 7230 4 ) ) -RRB- cord-010092-uftc8inx 7230 5 , , , cord-010092-uftc8inx 7230 6 platelet platelet NN cord-010092-uftc8inx 7230 7 derived derive VBN cord-010092-uftc8inx 7230 8 growth growth NN cord-010092-uftc8inx 7230 9 factor factor NN cord-010092-uftc8inx 7231 1 AA AA NNP cord-010092-uftc8inx 7231 2 ( ( -LRB- cord-010092-uftc8inx 7231 3 PDGF PDGF NNP cord-010092-uftc8inx 7231 4 - - HYPH cord-010092-uftc8inx 7231 5 AA AA NNP cord-010092-uftc8inx 7231 6 ) ) -RRB- cord-010092-uftc8inx 7231 7 and and CC cord-010092-uftc8inx 7231 8 serpin serpin NN cord-010092-uftc8inx 7231 9 E1 e1 NN cord-010092-uftc8inx 7231 10 ( ( -LRB- cord-010092-uftc8inx 7231 11 P p NN cord-010092-uftc8inx 7231 12 < < XX cord-010092-uftc8inx 7231 13 0.0001 0.0001 CD cord-010092-uftc8inx 7231 14 ) ) -RRB- cord-010092-uftc8inx 7231 15 . . . cord-010092-uftc8inx 7232 1 More more RBR cord-010092-uftc8inx 7232 2 highly highly RB cord-010092-uftc8inx 7232 3 prevalent prevalent JJ cord-010092-uftc8inx 7232 4 proteins protein NNS cord-010092-uftc8inx 7232 5 were be VBD cord-010092-uftc8inx 7232 6 detected detect VBN cord-010092-uftc8inx 7232 7 in in IN cord-010092-uftc8inx 7232 8 nPL nPL NNP cord-010092-uftc8inx 7232 9 ( ( -LRB- cord-010092-uftc8inx 7232 10 10/48 10/48 CD cord-010092-uftc8inx 7232 11 ) ) -RRB- cord-010092-uftc8inx 7232 12 compared compare VBN cord-010092-uftc8inx 7232 13 to to IN cord-010092-uftc8inx 7232 14 aPL aPL NNP cord-010092-uftc8inx 7232 15 ( ( -LRB- cord-010092-uftc8inx 7232 16 1/48 1/48 CD cord-010092-uftc8inx 7232 17 ) ) -RRB- cord-010092-uftc8inx 7232 18 , , , cord-010092-uftc8inx 7232 19 and and CC cord-010092-uftc8inx 7232 20 20 20 CD cord-010092-uftc8inx 7232 21 proteins protein NNS cord-010092-uftc8inx 7232 22 were be VBD cord-010092-uftc8inx 7232 23 significantly significantly RB cord-010092-uftc8inx 7232 24 elevated elevate VBN cord-010092-uftc8inx 7232 25 including include VBG cord-010092-uftc8inx 7232 26 vascular vascular JJ cord-010092-uftc8inx 7232 27 cell cell NN cord-010092-uftc8inx 7232 28 adhesion adhesion NN cord-010092-uftc8inx 7232 29 molecule-1 molecule-1 NNP cord-010092-uftc8inx 7232 30 ( ( -LRB- cord-010092-uftc8inx 7232 31 VCAM-1 VCAM-1 NNP cord-010092-uftc8inx 7232 32 ) ) -RRB- cord-010092-uftc8inx 7232 33 , , , cord-010092-uftc8inx 7232 34 platelet platelet NN cord-010092-uftc8inx 7232 35 factor factor NN cord-010092-uftc8inx 7232 36 4 4 CD cord-010092-uftc8inx 7232 37 ( ( -LRB- cord-010092-uftc8inx 7232 38 PF4 pf4 NN cord-010092-uftc8inx 7232 39 / / SYM cord-010092-uftc8inx 7232 40 CXCL4 cxcl4 NN cord-010092-uftc8inx 7232 41 ) ) -RRB- cord-010092-uftc8inx 7232 42 , , , cord-010092-uftc8inx 7232 43 epidermal epidermal JJ cord-010092-uftc8inx 7232 44 growth growth NN cord-010092-uftc8inx 7232 45 factor factor NN cord-010092-uftc8inx 7232 46 and and CC cord-010092-uftc8inx 7232 47 lipocalin-2 lipocalin-2 NNP cord-010092-uftc8inx 7232 48 ( ( -LRB- cord-010092-uftc8inx 7232 49 P p NN cord-010092-uftc8inx 7232 50 < < XX cord-010092-uftc8inx 7232 51 0.0001 0.0001 CD cord-010092-uftc8inx 7232 52 ) ) -RRB- cord-010092-uftc8inx 7232 53 . . . cord-010092-uftc8inx 7233 1 In in IN cord-010092-uftc8inx 7233 2 adult adult NN cord-010092-uftc8inx 7233 3 samples sample NNS cord-010092-uftc8inx 7233 4 only only RB cord-010092-uftc8inx 7233 5 10 10 CD cord-010092-uftc8inx 7233 6 proteins protein NNS cord-010092-uftc8inx 7233 7 were be VBD cord-010092-uftc8inx 7233 8 significantly significantly RB cord-010092-uftc8inx 7233 9 higher high JJR cord-010092-uftc8inx 7233 10 in in IN cord-010092-uftc8inx 7233 11 plasma plasma NN cord-010092-uftc8inx 7233 12 and and CC cord-010092-uftc8inx 7233 13 three three CD cord-010092-uftc8inx 7233 14 proteins protein NNS cord-010092-uftc8inx 7233 15 in in IN cord-010092-uftc8inx 7233 16 aPL aPL NNS cord-010092-uftc8inx 7233 17 compared compare VBN cord-010092-uftc8inx 7233 18 to to IN cord-010092-uftc8inx 7233 19 the the DT cord-010092-uftc8inx 7233 20 neonatal neonatal JJ cord-010092-uftc8inx 7233 21 groups group NNS cord-010092-uftc8inx 7233 22 ( ( -LRB- cord-010092-uftc8inx 7233 23 P p NN cord-010092-uftc8inx 7233 24 < < XX cord-010092-uftc8inx 7233 25 0.05 0.05 CD cord-010092-uftc8inx 7233 26 to to IN cord-010092-uftc8inx 7233 27 P p NN cord-010092-uftc8inx 7233 28 < < XX cord-010092-uftc8inx 7233 29 0.0001 0.0001 CD cord-010092-uftc8inx 7233 30 ) ) -RRB- cord-010092-uftc8inx 7233 31 . . . cord-010092-uftc8inx 7234 1 Summary Summary NNP cord-010092-uftc8inx 7234 2 / / SYM cord-010092-uftc8inx 7234 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 7234 4 : : : cord-010092-uftc8inx 7235 1 We -PRON- PRP cord-010092-uftc8inx 7235 2 detected detect VBD cord-010092-uftc8inx 7235 3 significant significant JJ cord-010092-uftc8inx 7235 4 differences difference NNS cord-010092-uftc8inx 7235 5 in in IN cord-010092-uftc8inx 7235 6 regenerative regenerative JJ cord-010092-uftc8inx 7235 7 growth growth NN cord-010092-uftc8inx 7235 8 factor factor NN cord-010092-uftc8inx 7235 9 and and CC cord-010092-uftc8inx 7235 10 cytokine cytokine NN cord-010092-uftc8inx 7235 11 contents content NNS cord-010092-uftc8inx 7235 12 of of IN cord-010092-uftc8inx 7235 13 neonatal neonatal JJ cord-010092-uftc8inx 7235 14 and and CC cord-010092-uftc8inx 7235 15 adult adult NN cord-010092-uftc8inx 7235 16 plasma plasma NN cord-010092-uftc8inx 7235 17 and and CC cord-010092-uftc8inx 7235 18 platelet platelet NN cord-010092-uftc8inx 7235 19 samples sample NNS cord-010092-uftc8inx 7235 20 , , , cord-010092-uftc8inx 7235 21 respectively respectively RB cord-010092-uftc8inx 7235 22 . . . cord-010092-uftc8inx 7236 1 Additional additional JJ cord-010092-uftc8inx 7236 2 experiments experiment NNS cord-010092-uftc8inx 7236 3 are be VBP cord-010092-uftc8inx 7236 4 underway underway JJ cord-010092-uftc8inx 7236 5 to to TO cord-010092-uftc8inx 7236 6 further further RB cord-010092-uftc8inx 7236 7 characterize characterize VB cord-010092-uftc8inx 7236 8 their -PRON- PRP$ cord-010092-uftc8inx 7236 9 impact impact NN cord-010092-uftc8inx 7236 10 in in IN cord-010092-uftc8inx 7236 11 distinct distinct JJ cord-010092-uftc8inx 7236 12 functional functional JJ cord-010092-uftc8inx 7236 13 readouts readout NNS cord-010092-uftc8inx 7236 14 . . . cord-010092-uftc8inx 7237 1 Background background NN cord-010092-uftc8inx 7237 2 : : : cord-010092-uftc8inx 7238 1 The the DT cord-010092-uftc8inx 7238 2 production production NN cord-010092-uftc8inx 7238 3 and and CC cord-010092-uftc8inx 7238 4 storage storage NN cord-010092-uftc8inx 7238 5 conditions condition NNS cord-010092-uftc8inx 7238 6 of of IN cord-010092-uftc8inx 7238 7 platelet platelet NN cord-010092-uftc8inx 7238 8 ( ( -LRB- cord-010092-uftc8inx 7238 9 PL pl NN cord-010092-uftc8inx 7238 10 ) ) -RRB- cord-010092-uftc8inx 7238 11 products product NNS cord-010092-uftc8inx 7238 12 intended intend VBN cord-010092-uftc8inx 7238 13 for for IN cord-010092-uftc8inx 7238 14 transfusion transfusion NN cord-010092-uftc8inx 7238 15 are be VBP cord-010092-uftc8inx 7238 16 constantly constantly RB cord-010092-uftc8inx 7238 17 evolving evolve VBG cord-010092-uftc8inx 7238 18 and and CC cord-010092-uftc8inx 7238 19 need need VBP cord-010092-uftc8inx 7238 20 sometimes sometimes RB cord-010092-uftc8inx 7238 21 in in IN cord-010092-uftc8inx 7238 22 vivo vivo NN cord-010092-uftc8inx 7238 23 evaluations evaluation NNS cord-010092-uftc8inx 7238 24 in in IN cord-010092-uftc8inx 7238 25 clinical clinical JJ cord-010092-uftc8inx 7238 26 trials trial NNS cord-010092-uftc8inx 7238 27 to to TO cord-010092-uftc8inx 7238 28 ascertain ascertain VB cord-010092-uftc8inx 7238 29 whether whether IN cord-010092-uftc8inx 7238 30 the the DT cord-010092-uftc8inx 7238 31 platelets platelet NNS cord-010092-uftc8inx 7238 32 have have VBP cord-010092-uftc8inx 7238 33 retained retain VBN cord-010092-uftc8inx 7238 34 their -PRON- PRP$ cord-010092-uftc8inx 7238 35 ability ability NN cord-010092-uftc8inx 7238 36 to to TO cord-010092-uftc8inx 7238 37 survive survive VB cord-010092-uftc8inx 7238 38 in in IN cord-010092-uftc8inx 7238 39 the the DT cord-010092-uftc8inx 7238 40 circulation circulation NN cord-010092-uftc8inx 7238 41 . . . cord-010092-uftc8inx 7239 1 This this DT cord-010092-uftc8inx 7239 2 requires require VBZ cord-010092-uftc8inx 7239 3 that that IN cord-010092-uftc8inx 7239 4 the the DT cord-010092-uftc8inx 7239 5 transfused transfused JJ cord-010092-uftc8inx 7239 6 platelets platelet NNS cord-010092-uftc8inx 7239 7 can can MD cord-010092-uftc8inx 7239 8 be be VB cord-010092-uftc8inx 7239 9 distinguished distinguish VBN cord-010092-uftc8inx 7239 10 from from IN cord-010092-uftc8inx 7239 11 the the DT cord-010092-uftc8inx 7239 12 recipient recipient NN cord-010092-uftc8inx 7239 13 's 's POS cord-010092-uftc8inx 7239 14 circulating circulate VBG cord-010092-uftc8inx 7239 15 platelets platelet NNS cord-010092-uftc8inx 7239 16 . . . cord-010092-uftc8inx 7240 1 Labeling labeling NN cord-010092-uftc8inx 7240 2 of of IN cord-010092-uftc8inx 7240 3 platelets platelet NNS cord-010092-uftc8inx 7240 4 with with IN cord-010092-uftc8inx 7240 5 biotin biotin NN cord-010092-uftc8inx 7240 6 ( ( -LRB- cord-010092-uftc8inx 7240 7 Bio Bio NNP cord-010092-uftc8inx 7240 8 ) ) -RRB- cord-010092-uftc8inx 7240 9 affords afford VBZ cord-010092-uftc8inx 7240 10 to to TO cord-010092-uftc8inx 7240 11 track track VB cord-010092-uftc8inx 7240 12 in in IN cord-010092-uftc8inx 7240 13 vivo vivo NN cord-010092-uftc8inx 7240 14 and and CC cord-010092-uftc8inx 7240 15 concurrently concurrently RB cord-010092-uftc8inx 7240 16 , , , cord-010092-uftc8inx 7240 17 multiple multiple JJ cord-010092-uftc8inx 7240 18 cell cell NN cord-010092-uftc8inx 7240 19 populations population NNS cord-010092-uftc8inx 7240 20 covered cover VBN cord-010092-uftc8inx 7240 21 with with IN cord-010092-uftc8inx 7240 22 various various JJ cord-010092-uftc8inx 7240 23 biotin biotin NN cord-010092-uftc8inx 7240 24 densities density NNS cord-010092-uftc8inx 7240 25 as as RB cord-010092-uftc8inx 7240 26 already already RB cord-010092-uftc8inx 7240 27 described describe VBN cord-010092-uftc8inx 7240 28 for for IN cord-010092-uftc8inx 7240 29 red red JJ cord-010092-uftc8inx 7240 30 blood blood NN cord-010092-uftc8inx 7240 31 cells cell NNS cord-010092-uftc8inx 7240 32 ( ( -LRB- cord-010092-uftc8inx 7240 33 Mock Mock NNP cord-010092-uftc8inx 7240 34 , , , cord-010092-uftc8inx 7240 35 Transfusion Transfusion NNP cord-010092-uftc8inx 7240 36 , , , cord-010092-uftc8inx 7240 37 2018 2018 CD cord-010092-uftc8inx 7240 38 ) ) -RRB- cord-010092-uftc8inx 7240 39 . . . cord-010092-uftc8inx 7241 1 Surprisingly surprisingly RB cord-010092-uftc8inx 7241 2 , , , cord-010092-uftc8inx 7241 3 there there EX cord-010092-uftc8inx 7241 4 is be VBZ cord-010092-uftc8inx 7241 5 only only RB cord-010092-uftc8inx 7241 6 one one CD cord-010092-uftc8inx 7241 7 study study NN cord-010092-uftc8inx 7241 8 describing describe VBG cord-010092-uftc8inx 7241 9 the the DT cord-010092-uftc8inx 7241 10 transfusion transfusion NN cord-010092-uftc8inx 7241 11 of of IN cord-010092-uftc8inx 7241 12 human human JJ cord-010092-uftc8inx 7241 13 BioPL BioPL NNP cord-010092-uftc8inx 7241 14 ( ( -LRB- cord-010092-uftc8inx 7241 15 Stohlawetz Stohlawetz NNP cord-010092-uftc8inx 7241 16 , , , cord-010092-uftc8inx 7241 17 Transfusion Transfusion NNP cord-010092-uftc8inx 7241 18 , , , cord-010092-uftc8inx 7241 19 1999 1999 CD cord-010092-uftc8inx 7241 20 ) ) -RRB- cord-010092-uftc8inx 7241 21 . . . cord-010092-uftc8inx 7242 1 So so RB cord-010092-uftc8inx 7242 2 far far RB cord-010092-uftc8inx 7242 3 , , , cord-010092-uftc8inx 7242 4 the the DT cord-010092-uftc8inx 7242 5 biotinylation biotinylation NN cord-010092-uftc8inx 7242 6 reagent reagent NN cord-010092-uftc8inx 7242 7 Bio Bio NNP cord-010092-uftc8inx 7242 8 - - HYPH cord-010092-uftc8inx 7242 9 SulfoNHS SulfoNHS NNP cord-010092-uftc8inx 7242 10 was be VBD cord-010092-uftc8inx 7242 11 not not RB cord-010092-uftc8inx 7242 12 complying comply VBG cord-010092-uftc8inx 7242 13 with with IN cord-010092-uftc8inx 7242 14 good good JJ cord-010092-uftc8inx 7242 15 manufacturing manufacturing NN cord-010092-uftc8inx 7242 16 practices practice NNS cord-010092-uftc8inx 7242 17 ( ( -LRB- cord-010092-uftc8inx 7242 18 GMP GMP NNP cord-010092-uftc8inx 7242 19 ) ) -RRB- cord-010092-uftc8inx 7242 20 , , , cord-010092-uftc8inx 7242 21 which which WDT cord-010092-uftc8inx 7242 22 represents represent VBZ cord-010092-uftc8inx 7242 23 an an DT cord-010092-uftc8inx 7242 24 obstacle obstacle NN cord-010092-uftc8inx 7242 25 regarding regard VBG cord-010092-uftc8inx 7242 26 the the DT cord-010092-uftc8inx 7242 27 regulatory regulatory JJ cord-010092-uftc8inx 7242 28 authorities authority NNS cord-010092-uftc8inx 7242 29 . . . cord-010092-uftc8inx 7243 1 Aims aim VBZ cord-010092-uftc8inx 7243 2 : : : cord-010092-uftc8inx 7244 1 The the DT cord-010092-uftc8inx 7244 2 aims aim NNS cord-010092-uftc8inx 7244 3 of of IN cord-010092-uftc8inx 7244 4 this this DT cord-010092-uftc8inx 7244 5 study study NN cord-010092-uftc8inx 7244 6 are be VBP cord-010092-uftc8inx 7244 7 1 1 CD cord-010092-uftc8inx 7244 8 ) ) -RRB- cord-010092-uftc8inx 7244 9 to to TO cord-010092-uftc8inx 7244 10 describe describe VB cord-010092-uftc8inx 7244 11 a a DT cord-010092-uftc8inx 7244 12 procedure procedure NN cord-010092-uftc8inx 7244 13 to to TO cord-010092-uftc8inx 7244 14 label label VB cord-010092-uftc8inx 7244 15 injectable injectable JJ cord-010092-uftc8inx 7244 16 human human JJ cord-010092-uftc8inx 7244 17 platelets platelet NNS cord-010092-uftc8inx 7244 18 with with IN cord-010092-uftc8inx 7244 19 2 2 CD cord-010092-uftc8inx 7244 20 densities density NNS cord-010092-uftc8inx 7244 21 of of IN cord-010092-uftc8inx 7244 22 biotin biotin NN cord-010092-uftc8inx 7244 23 , , , cord-010092-uftc8inx 7244 24 2 2 CD cord-010092-uftc8inx 7244 25 ) ) -RRB- cord-010092-uftc8inx 7244 26 to to TO cord-010092-uftc8inx 7244 27 evaluate evaluate VB cord-010092-uftc8inx 7244 28 the the DT cord-010092-uftc8inx 7244 29 impact impact NN cord-010092-uftc8inx 7244 30 of of IN cord-010092-uftc8inx 7244 31 biotinylation biotinylation NN cord-010092-uftc8inx 7244 32 on on IN cord-010092-uftc8inx 7244 33 platelet platelet NN cord-010092-uftc8inx 7244 34 functions function NNS cord-010092-uftc8inx 7244 35 , , , cord-010092-uftc8inx 7244 36 3 3 CD cord-010092-uftc8inx 7244 37 ) ) -RRB- cord-010092-uftc8inx 7244 38 to to TO cord-010092-uftc8inx 7244 39 track track VB cord-010092-uftc8inx 7244 40 human human JJ cord-010092-uftc8inx 7244 41 BioPL biopl NN cord-010092-uftc8inx 7244 42 in in IN cord-010092-uftc8inx 7244 43 the the DT cord-010092-uftc8inx 7244 44 circulation circulation NN cord-010092-uftc8inx 7244 45 of of IN cord-010092-uftc8inx 7244 46 the the DT cord-010092-uftc8inx 7244 47 mouse mouse NN cord-010092-uftc8inx 7244 48 . . . cord-010092-uftc8inx 7245 1 Methods method NNS cord-010092-uftc8inx 7245 2 : : : cord-010092-uftc8inx 7246 1 Platelets platelet NNS cord-010092-uftc8inx 7246 2 are be VBP cord-010092-uftc8inx 7246 3 taken take VBN cord-010092-uftc8inx 7246 4 from from IN cord-010092-uftc8inx 7246 5 standard standard JJ cord-010092-uftc8inx 7246 6 platelets platelet NNS cord-010092-uftc8inx 7246 7 concentrates concentrate VBZ cord-010092-uftc8inx 7246 8 and and CC cord-010092-uftc8inx 7246 9 treated treat VBN cord-010092-uftc8inx 7246 10 with with IN cord-010092-uftc8inx 7246 11 1.2 1.2 CD cord-010092-uftc8inx 7246 12 and and CC cord-010092-uftc8inx 7246 13 10 10 CD cord-010092-uftc8inx 7246 14 lg lg NN cord-010092-uftc8inx 7246 15 / / SYM cord-010092-uftc8inx 7246 16 mL mL NNP cord-010092-uftc8inx 7246 17 BioSulfoNHS BioSulfoNHS NNP cord-010092-uftc8inx 7246 18 of of IN cord-010092-uftc8inx 7246 19 GMP GMP NNP cord-010092-uftc8inx 7246 20 - - HYPH cord-010092-uftc8inx 7246 21 grade grade NN cord-010092-uftc8inx 7246 22 , , , cord-010092-uftc8inx 7246 23 recently recently RB cord-010092-uftc8inx 7246 24 commercialized commercialize VBN cord-010092-uftc8inx 7246 25 . . . cord-010092-uftc8inx 7247 1 Main main JJ cord-010092-uftc8inx 7247 2 platelet platelet NN cord-010092-uftc8inx 7247 3 functions function NNS cord-010092-uftc8inx 7247 4 are be VBP cord-010092-uftc8inx 7247 5 assessed assess VBN cord-010092-uftc8inx 7247 6 in in IN cord-010092-uftc8inx 7247 7 vitro vitro FW cord-010092-uftc8inx 7247 8 . . . cord-010092-uftc8inx 7248 1 Human human JJ cord-010092-uftc8inx 7248 2 BioPL biopl JJ cord-010092-uftc8inx 7248 3 survival survival NN cord-010092-uftc8inx 7248 4 is be VBZ cord-010092-uftc8inx 7248 5 evaluated evaluate VBN cord-010092-uftc8inx 7248 6 in in IN cord-010092-uftc8inx 7248 7 immunodeficient immunodeficient JJ cord-010092-uftc8inx 7248 8 NSG NSG NNP cord-010092-uftc8inx 7248 9 - - HYPH cord-010092-uftc8inx 7248 10 mice mouse NNS cord-010092-uftc8inx 7248 11 treated treat VBN cord-010092-uftc8inx 7248 12 with with IN cord-010092-uftc8inx 7248 13 liposome liposome NN cord-010092-uftc8inx 7248 14 - - HYPH cord-010092-uftc8inx 7248 15 clodronate clodronate NN cord-010092-uftc8inx 7248 16 to to TO cord-010092-uftc8inx 7248 17 eliminate eliminate VB cord-010092-uftc8inx 7248 18 macrophages macrophage NNS cord-010092-uftc8inx 7248 19 and and CC cord-010092-uftc8inx 7248 20 to to TO cord-010092-uftc8inx 7248 21 prevent prevent VB cord-010092-uftc8inx 7248 22 rejection rejection NN cord-010092-uftc8inx 7248 23 . . . cord-010092-uftc8inx 7249 1 Circulating circulate VBG cord-010092-uftc8inx 7249 2 human human JJ cord-010092-uftc8inx 7249 3 BioPL BioPL NNP cord-010092-uftc8inx 7249 4 are be VBP cord-010092-uftc8inx 7249 5 detected detect VBN cord-010092-uftc8inx 7249 6 ex ex FW cord-010092-uftc8inx 7249 7 vivo vivo NN cord-010092-uftc8inx 7249 8 by by IN cord-010092-uftc8inx 7249 9 flow flow NN cord-010092-uftc8inx 7249 10 cytometry cytometry NN cord-010092-uftc8inx 7249 11 with with IN cord-010092-uftc8inx 7249 12 streptavidin streptavidin NNP cord-010092-uftc8inx 7249 13 phycoerythrin phycoerythrin NNP cord-010092-uftc8inx 7249 14 . . . cord-010092-uftc8inx 7250 1 Results result NNS cord-010092-uftc8inx 7250 2 : : : cord-010092-uftc8inx 7251 1 Using use VBG cord-010092-uftc8inx 7251 2 TRAP trap NN cord-010092-uftc8inx 7251 3 ( ( -LRB- cord-010092-uftc8inx 7251 4 60 60 CD cord-010092-uftc8inx 7251 5 lM lm NN cord-010092-uftc8inx 7251 6 ) ) -RRB- cord-010092-uftc8inx 7251 7 , , , cord-010092-uftc8inx 7251 8 P p NN cord-010092-uftc8inx 7251 9 - - HYPH cord-010092-uftc8inx 7251 10 selectin selectin NNP cord-010092-uftc8inx 7251 11 externalization externalization NN cord-010092-uftc8inx 7251 12 reveals reveal VBZ cord-010092-uftc8inx 7251 13 a a DT cord-010092-uftc8inx 7251 14 normal normal JJ cord-010092-uftc8inx 7251 15 capacity capacity NN cord-010092-uftc8inx 7251 16 of of IN cord-010092-uftc8inx 7251 17 secretion secretion NN cord-010092-uftc8inx 7251 18 for for IN cord-010092-uftc8inx 7251 19 all all DT cord-010092-uftc8inx 7251 20 BioPL biopl NN cord-010092-uftc8inx 7251 21 . . . cord-010092-uftc8inx 7252 1 GPIba GPIba NNP cord-010092-uftc8inx 7252 2 and and CC cord-010092-uftc8inx 7252 3 GPIIbIIIa gpiibiiia JJ cord-010092-uftc8inx 7252 4 expression expression NN cord-010092-uftc8inx 7252 5 is be VBZ cord-010092-uftc8inx 7252 6 not not RB cord-010092-uftc8inx 7252 7 affected affect VBN cord-010092-uftc8inx 7252 8 by by IN cord-010092-uftc8inx 7252 9 the the DT cord-010092-uftc8inx 7252 10 biotinylation biotinylation NN cord-010092-uftc8inx 7252 11 process process NN cord-010092-uftc8inx 7252 12 . . . cord-010092-uftc8inx 7253 1 BioPL BioPL NNS cord-010092-uftc8inx 7253 2 have have VB cord-010092-uftc8inx 7253 3 the the DT cord-010092-uftc8inx 7253 4 ability ability NN cord-010092-uftc8inx 7253 5 to to TO cord-010092-uftc8inx 7253 6 aggregate aggregate VB cord-010092-uftc8inx 7253 7 : : : cord-010092-uftc8inx 7253 8 using use VBG cord-010092-uftc8inx 7253 9 arachidonic arachidonic JJ cord-010092-uftc8inx 7253 10 acid acid NN cord-010092-uftc8inx 7253 11 ( ( -LRB- cord-010092-uftc8inx 7253 12 1 1 CD cord-010092-uftc8inx 7253 13 mM mm CD cord-010092-uftc8inx 7253 14 ) ) -RRB- cord-010092-uftc8inx 7253 15 , , , cord-010092-uftc8inx 7253 16 amplitude amplitude NN cord-010092-uftc8inx 7253 17 of of IN cord-010092-uftc8inx 7253 18 aggregation aggregation NN cord-010092-uftc8inx 7253 19 is be VBZ cord-010092-uftc8inx 7253 20 81.7 81.7 CD cord-010092-uftc8inx 7253 21 AE AE NNP cord-010092-uftc8inx 7253 22 2.5 2.5 CD cord-010092-uftc8inx 7253 23 % % NN cord-010092-uftc8inx 7253 24 ( ( -LRB- cord-010092-uftc8inx 7253 25 Bio Bio NNP cord-010092-uftc8inx 7253 26 0 0 CD cord-010092-uftc8inx 7253 27 ) ) -RRB- cord-010092-uftc8inx 7253 28 ; ; : cord-010092-uftc8inx 7253 29 82.6 82.6 CD cord-010092-uftc8inx 7253 30 AE AE NNP cord-010092-uftc8inx 7253 31 2.3 2.3 CD cord-010092-uftc8inx 7253 32 % % NN cord-010092-uftc8inx 7254 1 ( ( -LRB- cord-010092-uftc8inx 7254 2 Bio Bio NNP cord-010092-uftc8inx 7254 3 1.2 1.2 CD cord-010092-uftc8inx 7254 4 lg/ lg/ NN cord-010092-uftc8inx 7254 5 mL ml NN cord-010092-uftc8inx 7254 6 ) ) -RRB- cord-010092-uftc8inx 7254 7 ; ; : cord-010092-uftc8inx 7254 8 79.2 79.2 CD cord-010092-uftc8inx 7254 9 AE AE NNP cord-010092-uftc8inx 7254 10 1.6 1.6 CD cord-010092-uftc8inx 7254 11 % % NN cord-010092-uftc8inx 7255 1 ( ( -LRB- cord-010092-uftc8inx 7255 2 Bio Bio NNP cord-010092-uftc8inx 7255 3 10 10 CD cord-010092-uftc8inx 7255 4 lg lg NNP cord-010092-uftc8inx 7255 5 / / SYM cord-010092-uftc8inx 7255 6 mL mL NNP cord-010092-uftc8inx 7255 7 ) ) -RRB- cord-010092-uftc8inx 7255 8 . . . cord-010092-uftc8inx 7256 1 Using use VBG cord-010092-uftc8inx 7256 2 collagen collagen NN cord-010092-uftc8inx 7256 3 ( ( -LRB- cord-010092-uftc8inx 7256 4 2.5 2.5 CD cord-010092-uftc8inx 7256 5 lg lg NNP cord-010092-uftc8inx 7256 6 / / SYM cord-010092-uftc8inx 7256 7 mL mL NNP cord-010092-uftc8inx 7256 8 ) ) -RRB- cord-010092-uftc8inx 7256 9 , , , cord-010092-uftc8inx 7256 10 amplitude amplitude NN cord-010092-uftc8inx 7256 11 of of IN cord-010092-uftc8inx 7256 12 aggregation aggregation NN cord-010092-uftc8inx 7256 13 is be VBZ cord-010092-uftc8inx 7256 14 65.6 65.6 CD cord-010092-uftc8inx 7256 15 AE AE NNP cord-010092-uftc8inx 7256 16 4.2 4.2 CD cord-010092-uftc8inx 7256 17 % % NN cord-010092-uftc8inx 7256 18 ( ( -LRB- cord-010092-uftc8inx 7256 19 Bio Bio NNP cord-010092-uftc8inx 7256 20 0 0 CD cord-010092-uftc8inx 7256 21 ) ) -RRB- cord-010092-uftc8inx 7256 22 ; ; : cord-010092-uftc8inx 7256 23 61.4 61.4 CD cord-010092-uftc8inx 7256 24 AE AE NNP cord-010092-uftc8inx 7256 25 4.0 4.0 CD cord-010092-uftc8inx 7256 26 % % NN cord-010092-uftc8inx 7257 1 ( ( -LRB- cord-010092-uftc8inx 7257 2 Bio Bio NNP cord-010092-uftc8inx 7257 3 1.2 1.2 CD cord-010092-uftc8inx 7257 4 lg lg NNP cord-010092-uftc8inx 7257 5 / / SYM cord-010092-uftc8inx 7257 6 mL ml NN cord-010092-uftc8inx 7257 7 ) ) -RRB- cord-010092-uftc8inx 7257 8 40.8 40.8 CD cord-010092-uftc8inx 7257 9 AE AE NNP cord-010092-uftc8inx 7257 10 6.6 6.6 CD cord-010092-uftc8inx 7257 11 % % NN cord-010092-uftc8inx 7257 12 ( ( -LRB- cord-010092-uftc8inx 7257 13 Bio Bio NNP cord-010092-uftc8inx 7257 14 10 10 CD cord-010092-uftc8inx 7257 15 lg lg NNP cord-010092-uftc8inx 7257 16 / / SYM cord-010092-uftc8inx 7257 17 mL mL NNP cord-010092-uftc8inx 7257 18 ) ) -RRB- cord-010092-uftc8inx 7257 19 . . . cord-010092-uftc8inx 7258 1 The the DT cord-010092-uftc8inx 7258 2 2 2 CD cord-010092-uftc8inx 7258 3 BioPL biopl JJ cord-010092-uftc8inx 7258 4 populations population NNS cord-010092-uftc8inx 7258 5 could could MD cord-010092-uftc8inx 7258 6 be be VB cord-010092-uftc8inx 7258 7 easily easily RB cord-010092-uftc8inx 7258 8 distinguished distinguish VBN cord-010092-uftc8inx 7258 9 between between IN cord-010092-uftc8inx 7258 10 themselves -PRON- PRP cord-010092-uftc8inx 7258 11 and and CC cord-010092-uftc8inx 7258 12 from from IN cord-010092-uftc8inx 7258 13 unlabeled unlabeled JJ cord-010092-uftc8inx 7258 14 blood blood NN cord-010092-uftc8inx 7258 15 cells cell NNS cord-010092-uftc8inx 7258 16 in in IN cord-010092-uftc8inx 7258 17 the the DT cord-010092-uftc8inx 7258 18 mouse mouse NN cord-010092-uftc8inx 7258 19 circulation circulation NN cord-010092-uftc8inx 7258 20 during during IN cord-010092-uftc8inx 7258 21 more more JJR cord-010092-uftc8inx 7258 22 than than IN cord-010092-uftc8inx 7258 23 48 48 CD cord-010092-uftc8inx 7258 24 h. h. NN cord-010092-uftc8inx 7259 1 After after IN cord-010092-uftc8inx 7259 2 4 4 CD cord-010092-uftc8inx 7259 3 h h NN cord-010092-uftc8inx 7259 4 , , , cord-010092-uftc8inx 7259 5 the the DT cord-010092-uftc8inx 7259 6 mean mean JJ cord-010092-uftc8inx 7259 7 fluorescence fluorescence NN cord-010092-uftc8inx 7259 8 intensities intensity NNS cord-010092-uftc8inx 7259 9 are be VBP cord-010092-uftc8inx 7259 10 0.13 0.13 CD cord-010092-uftc8inx 7259 11 AE AE NNP cord-010092-uftc8inx 7259 12 0.02 0.02 CD cord-010092-uftc8inx 7259 13 for for IN cord-010092-uftc8inx 7259 14 unlabeled unlabeled JJ cord-010092-uftc8inx 7259 15 circulating circulate VBG cord-010092-uftc8inx 7259 16 mouse mouse NN cord-010092-uftc8inx 7259 17 platelets platelet NNS cord-010092-uftc8inx 7259 18 , , , cord-010092-uftc8inx 7259 19 1.01 1.01 CD cord-010092-uftc8inx 7259 20 AE AE NNP cord-010092-uftc8inx 7259 21 0.03 0.03 CD cord-010092-uftc8inx 7259 22 and and CC cord-010092-uftc8inx 7259 23 8.2 8.2 CD cord-010092-uftc8inx 7259 24 AE AE NNP cord-010092-uftc8inx 7259 25 0.15 0.15 CD cord-010092-uftc8inx 7259 26 for for IN cord-010092-uftc8inx 7259 27 circulating circulate VBG cord-010092-uftc8inx 7259 28 human human JJ cord-010092-uftc8inx 7259 29 BioPL BioPL NNS cord-010092-uftc8inx 7259 30 covered cover VBN cord-010092-uftc8inx 7259 31 respectively respectively RB cord-010092-uftc8inx 7259 32 with with IN cord-010092-uftc8inx 7259 33 1.2 1.2 CD cord-010092-uftc8inx 7259 34 and and CC cord-010092-uftc8inx 7259 35 10 10 CD cord-010092-uftc8inx 7259 36 lg lg NN cord-010092-uftc8inx 7259 37 / / SYM cord-010092-uftc8inx 7259 38 mL ml NN cord-010092-uftc8inx 7259 39 biotin biotin NN cord-010092-uftc8inx 7259 40 . . . cord-010092-uftc8inx 7260 1 Summary Summary NNP cord-010092-uftc8inx 7260 2 / / SYM cord-010092-uftc8inx 7260 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 7260 4 : : : cord-010092-uftc8inx 7261 1 This this DT cord-010092-uftc8inx 7261 2 labeling labeling NN cord-010092-uftc8inx 7261 3 approach approach NN cord-010092-uftc8inx 7261 4 should should MD cord-010092-uftc8inx 7261 5 be be VB cord-010092-uftc8inx 7261 6 helpful helpful JJ cord-010092-uftc8inx 7261 7 to to TO cord-010092-uftc8inx 7261 8 evaluate evaluate VB cord-010092-uftc8inx 7261 9 new new JJ cord-010092-uftc8inx 7261 10 platelet platelet NN cord-010092-uftc8inx 7261 11 products product NNS cord-010092-uftc8inx 7261 12 in in IN cord-010092-uftc8inx 7261 13 vivo vivo NN cord-010092-uftc8inx 7261 14 and and CC cord-010092-uftc8inx 7261 15 represents represent VBZ cord-010092-uftc8inx 7261 16 an an DT cord-010092-uftc8inx 7261 17 alternative alternative NN cord-010092-uftc8inx 7261 18 to to IN cord-010092-uftc8inx 7261 19 radioactive radioactive JJ cord-010092-uftc8inx 7261 20 tracers tracer NNS cord-010092-uftc8inx 7261 21 . . . cord-010092-uftc8inx 7262 1 It -PRON- PRP cord-010092-uftc8inx 7262 2 allows allow VBZ cord-010092-uftc8inx 7262 3 to to TO cord-010092-uftc8inx 7262 4 follow follow VB cord-010092-uftc8inx 7262 5 simultaneously simultaneously RB cord-010092-uftc8inx 7262 6 different different JJ cord-010092-uftc8inx 7262 7 platelet platelet NN cord-010092-uftc8inx 7262 8 populations population NNS cord-010092-uftc8inx 7262 9 and and CC cord-010092-uftc8inx 7262 10 consequently consequently RB cord-010092-uftc8inx 7262 11 limits limit VBZ cord-010092-uftc8inx 7262 12 the the DT cord-010092-uftc8inx 7262 13 number number NN cord-010092-uftc8inx 7262 14 of of IN cord-010092-uftc8inx 7262 15 volunteers volunteer NNS cord-010092-uftc8inx 7262 16 in in IN cord-010092-uftc8inx 7262 17 clinical clinical JJ cord-010092-uftc8inx 7262 18 trials trial NNS cord-010092-uftc8inx 7262 19 . . . cord-010092-uftc8inx 7263 1 Background background NN cord-010092-uftc8inx 7263 2 : : : cord-010092-uftc8inx 7264 1 Severe severe JJ cord-010092-uftc8inx 7264 2 ocular ocular JJ cord-010092-uftc8inx 7264 3 surface surface NN cord-010092-uftc8inx 7264 4 diseases disease NNS cord-010092-uftc8inx 7264 5 , , , cord-010092-uftc8inx 7264 6 Dry dry JJ cord-010092-uftc8inx 7264 7 eye eye NN cord-010092-uftc8inx 7264 8 syndrome syndrome NN cord-010092-uftc8inx 7264 9 , , , cord-010092-uftc8inx 7264 10 persistent persistent JJ cord-010092-uftc8inx 7264 11 and and CC cord-010092-uftc8inx 7264 12 recurrent recurrent JJ cord-010092-uftc8inx 7264 13 corneal corneal JJ cord-010092-uftc8inx 7264 14 epithelial epithelial JJ cord-010092-uftc8inx 7264 15 defects defect NNS cord-010092-uftc8inx 7264 16 and and CC cord-010092-uftc8inx 7264 17 diabetic diabetic JJ cord-010092-uftc8inx 7264 18 or or CC cord-010092-uftc8inx 7264 19 neurotrophic neurotrophic JJ cord-010092-uftc8inx 7264 20 keratopathy keratopathy NNP cord-010092-uftc8inx 7264 21 are be VBP cord-010092-uftc8inx 7264 22 mainly mainly RB cord-010092-uftc8inx 7264 23 successfully successfully RB cord-010092-uftc8inx 7264 24 cured cure VBN cord-010092-uftc8inx 7264 25 by by IN cord-010092-uftc8inx 7264 26 standard standard JJ cord-010092-uftc8inx 7264 27 treatment treatment NN cord-010092-uftc8inx 7264 28 protocols protocol NNS cord-010092-uftc8inx 7264 29 . . . cord-010092-uftc8inx 7265 1 However however RB cord-010092-uftc8inx 7265 2 , , , cord-010092-uftc8inx 7265 3 not not RB cord-010092-uftc8inx 7265 4 rarely rarely RB cord-010092-uftc8inx 7265 5 does do VBZ cord-010092-uftc8inx 7265 6 refractory refractory NN cord-010092-uftc8inx 7265 7 to to IN cord-010092-uftc8inx 7265 8 these these DT cord-010092-uftc8inx 7265 9 usual usual JJ cord-010092-uftc8inx 7265 10 treatments treatment NNS cord-010092-uftc8inx 7265 11 appear appear VBP cord-010092-uftc8inx 7265 12 , , , cord-010092-uftc8inx 7265 13 especially especially RB cord-010092-uftc8inx 7265 14 with with IN cord-010092-uftc8inx 7265 15 serious serious JJ cord-010092-uftc8inx 7265 16 forms form NNS cord-010092-uftc8inx 7265 17 of of IN cord-010092-uftc8inx 7265 18 disease disease NN cord-010092-uftc8inx 7265 19 . . . cord-010092-uftc8inx 7266 1 In in IN cord-010092-uftc8inx 7266 2 Military Military NNP cord-010092-uftc8inx 7266 3 Medical Medical NNP cord-010092-uftc8inx 7266 4 Academy Academy NNP cord-010092-uftc8inx 7266 5 , , , cord-010092-uftc8inx 7266 6 Autologous autologous JJ cord-010092-uftc8inx 7266 7 serum serum NN cord-010092-uftc8inx 7266 8 eye eye NN cord-010092-uftc8inx 7266 9 drops drop VBZ cord-010092-uftc8inx 7266 10 -Auto -Auto NNP cord-010092-uftc8inx 7266 11 SEDs sed NNS cord-010092-uftc8inx 7266 12 and and CC cord-010092-uftc8inx 7266 13 Autologous autologous JJ cord-010092-uftc8inx 7266 14 platelet platelet NN cord-010092-uftc8inx 7266 15 lysate lysate NN cord-010092-uftc8inx 7266 16 -APL -APL : cord-010092-uftc8inx 7266 17 eye eye NN cord-010092-uftc8inx 7266 18 drops drop NNS cord-010092-uftc8inx 7266 19 have have VBP cord-010092-uftc8inx 7266 20 been be VBN cord-010092-uftc8inx 7266 21 being be VBG cord-010092-uftc8inx 7266 22 applied apply VBN cord-010092-uftc8inx 7266 23 in in IN cord-010092-uftc8inx 7266 24 the the DT cord-010092-uftc8inx 7266 25 treatment treatment NN cord-010092-uftc8inx 7266 26 of of IN cord-010092-uftc8inx 7266 27 ophthalmological ophthalmological JJ cord-010092-uftc8inx 7266 28 patients patient NNS cord-010092-uftc8inx 7266 29 in in IN cord-010092-uftc8inx 7266 30 these these DT cord-010092-uftc8inx 7266 31 categories category NNS cord-010092-uftc8inx 7266 32 , , , cord-010092-uftc8inx 7266 33 who who WP cord-010092-uftc8inx 7266 34 were be VBD cord-010092-uftc8inx 7266 35 previously previously RB cord-010092-uftc8inx 7266 36 resistant resistant JJ cord-010092-uftc8inx 7266 37 to to IN cord-010092-uftc8inx 7266 38 standard standard JJ cord-010092-uftc8inx 7266 39 therapy therapy NN cord-010092-uftc8inx 7266 40 . . . cord-010092-uftc8inx 7267 1 Aims aim VBZ cord-010092-uftc8inx 7267 2 : : : cord-010092-uftc8inx 7268 1 To to TO cord-010092-uftc8inx 7268 2 show show VB cord-010092-uftc8inx 7268 3 the the DT cord-010092-uftc8inx 7268 4 achieved achieve VBN cord-010092-uftc8inx 7268 5 results result NNS cord-010092-uftc8inx 7268 6 of of IN cord-010092-uftc8inx 7268 7 therapeutic therapeutic JJ cord-010092-uftc8inx 7268 8 use use NN cord-010092-uftc8inx 7268 9 of of IN cord-010092-uftc8inx 7268 10 autologous autologous JJ cord-010092-uftc8inx 7268 11 blood blood NN cord-010092-uftc8inx 7268 12 products product NNS cord-010092-uftc8inx 7268 13 ( ( -LRB- cord-010092-uftc8inx 7268 14 Auto auto NN cord-010092-uftc8inx 7268 15 SEDs sed NNS cord-010092-uftc8inx 7268 16 and and CC cord-010092-uftc8inx 7268 17 APL APL NNP cord-010092-uftc8inx 7268 18 ) ) -RRB- cord-010092-uftc8inx 7268 19 in in IN cord-010092-uftc8inx 7268 20 the the DT cord-010092-uftc8inx 7268 21 treatment treatment NN cord-010092-uftc8inx 7268 22 of of IN cord-010092-uftc8inx 7268 23 ophthalmological ophthalmological JJ cord-010092-uftc8inx 7268 24 patients patient NNS cord-010092-uftc8inx 7268 25 who who WP cord-010092-uftc8inx 7268 26 previously previously RB cord-010092-uftc8inx 7268 27 had have VBD cord-010092-uftc8inx 7268 28 not not RB cord-010092-uftc8inx 7268 29 responded respond VBN cord-010092-uftc8inx 7268 30 to to IN cord-010092-uftc8inx 7268 31 conventional conventional JJ cord-010092-uftc8inx 7268 32 therapysingle therapysingle NNP cord-010092-uftc8inx 7268 33 center center NN cord-010092-uftc8inx 7268 34 experience experience NN cord-010092-uftc8inx 7268 35 . . . cord-010092-uftc8inx 7269 1 Methods method NNS cord-010092-uftc8inx 7269 2 : : : cord-010092-uftc8inx 7269 3 Auto auto NN cord-010092-uftc8inx 7269 4 SEDs sed NNS cord-010092-uftc8inx 7269 5 are be VBP cord-010092-uftc8inx 7269 6 prepared prepare VBN cord-010092-uftc8inx 7269 7 by by IN cord-010092-uftc8inx 7269 8 taking take VBG cord-010092-uftc8inx 7269 9 autologous autologous JJ cord-010092-uftc8inx 7269 10 blood blood NN cord-010092-uftc8inx 7269 11 into into IN cord-010092-uftc8inx 7269 12 tubes tube NNS cord-010092-uftc8inx 7269 13 ( ( -LRB- cord-010092-uftc8inx 7269 14 BD BD NNP cord-010092-uftc8inx 7269 15 Vacutainer Vacutainer NNP cord-010092-uftc8inx 7269 16 , , , cord-010092-uftc8inx 7269 17 CAT cat NN cord-010092-uftc8inx 7269 18 , , , cord-010092-uftc8inx 7269 19 10 10 CD cord-010092-uftc8inx 7269 20 ml ml NN cord-010092-uftc8inx 7269 21 ) ) -RRB- cord-010092-uftc8inx 7269 22 and and CC cord-010092-uftc8inx 7269 23 APL APL NNP cord-010092-uftc8inx 7269 24 in in IN cord-010092-uftc8inx 7269 25 tubes tube NNS cord-010092-uftc8inx 7269 26 with with IN cord-010092-uftc8inx 7269 27 anticoagulants anticoagulant NNS cord-010092-uftc8inx 7270 1 ( ( -LRB- cord-010092-uftc8inx 7270 2 Greiner Greiner NNP cord-010092-uftc8inx 7270 3 Bio Bio NNP cord-010092-uftc8inx 7270 4 - - HYPH cord-010092-uftc8inx 7270 5 One One NNP cord-010092-uftc8inx 7270 6 , , , cord-010092-uftc8inx 7270 7 ACD ACD NNP cord-010092-uftc8inx 7270 8 - - HYPH cord-010092-uftc8inx 7270 9 A A NNP cord-010092-uftc8inx 7270 10 , , , cord-010092-uftc8inx 7270 11 9 9 CD cord-010092-uftc8inx 7270 12 ml ml NN cord-010092-uftc8inx 7270 13 ) ) -RRB- cord-010092-uftc8inx 7270 14 . . . cord-010092-uftc8inx 7271 1 Control control NN cord-010092-uftc8inx 7271 2 on on IN cord-010092-uftc8inx 7271 3 TTI TTI NNP cord-010092-uftc8inx 7271 4 of of IN cord-010092-uftc8inx 7271 5 every every DT cord-010092-uftc8inx 7271 6 patient patient NN cord-010092-uftc8inx 7271 7 and and CC cord-010092-uftc8inx 7271 8 sterility sterility NN cord-010092-uftc8inx 7271 9 of of IN cord-010092-uftc8inx 7271 10 every every DT cord-010092-uftc8inx 7271 11 series series NN cord-010092-uftc8inx 7271 12 has have VBZ cord-010092-uftc8inx 7271 13 been be VBN cord-010092-uftc8inx 7271 14 conducted conduct VBN cord-010092-uftc8inx 7271 15 . . . cord-010092-uftc8inx 7272 1 Before before IN cord-010092-uftc8inx 7272 2 and and CC cord-010092-uftc8inx 7272 3 after after IN cord-010092-uftc8inx 7272 4 the the DT cord-010092-uftc8inx 7272 5 treatment treatment NN cord-010092-uftc8inx 7272 6 , , , cord-010092-uftc8inx 7272 7 subjective subjective JJ cord-010092-uftc8inx 7272 8 ocular ocular JJ cord-010092-uftc8inx 7272 9 discomfort discomfort NN cord-010092-uftc8inx 7272 10 ( ( -LRB- cord-010092-uftc8inx 7272 11 Ocular Ocular NNP cord-010092-uftc8inx 7272 12 Surface Surface NNP cord-010092-uftc8inx 7272 13 Disease Disease NNP cord-010092-uftc8inx 7272 14 Index Index NNP cord-010092-uftc8inx 7272 15 -OSDI -OSDI . cord-010092-uftc8inx 7272 16 ) ) -RRB- cord-010092-uftc8inx 7272 17 , , , cord-010092-uftc8inx 7272 18 objective objective JJ cord-010092-uftc8inx 7272 19 parameters parameter NNS cord-010092-uftc8inx 7272 20 of of IN cord-010092-uftc8inx 7272 21 the the DT cord-010092-uftc8inx 7272 22 tear tear JJ cord-010092-uftc8inx 7272 23 film film NN cord-010092-uftc8inx 7272 24 ( ( -LRB- cord-010092-uftc8inx 7272 25 Schirmer Schirmer NNP cord-010092-uftc8inx 7272 26 's 's POS cord-010092-uftc8inx 7272 27 test test NN cord-010092-uftc8inx 7272 28 , , , cord-010092-uftc8inx 7272 29 Rose Rose NNP cord-010092-uftc8inx 7272 30 Bengal Bengal NNP cord-010092-uftc8inx 7272 31 , , , cord-010092-uftc8inx 7272 32 Tear tear JJ cord-010092-uftc8inx 7272 33 breakup breakup NN cord-010092-uftc8inx 7272 34 time time NN cord-010092-uftc8inx 7272 35 -TBUT -TBUT '' cord-010092-uftc8inx 7272 36 ) ) -RRB- cord-010092-uftc8inx 7272 37 and and CC cord-010092-uftc8inx 7272 38 measuring measure VBG cord-010092-uftc8inx 7272 39 of of IN cord-010092-uftc8inx 7272 40 epithelialization epithelialization NN cord-010092-uftc8inx 7272 41 zone zone NN cord-010092-uftc8inx 7272 42 were be VBD cord-010092-uftc8inx 7272 43 analyzed analyze VBN cord-010092-uftc8inx 7272 44 . . . cord-010092-uftc8inx 7273 1 APL APL NNP cord-010092-uftc8inx 7273 2 , , , cord-010092-uftc8inx 7273 3 obtained obtain VBN cord-010092-uftc8inx 7273 4 from from IN cord-010092-uftc8inx 7273 5 platelet platelet NN cord-010092-uftc8inx 7273 6 - - HYPH cord-010092-uftc8inx 7273 7 rich rich JJ cord-010092-uftc8inx 7273 8 plasma plasma NN cord-010092-uftc8inx 7273 9 which which WDT cord-010092-uftc8inx 7273 10 had have VBD cord-010092-uftc8inx 7273 11 been be VBN cord-010092-uftc8inx 7273 12 frozen freeze VBN cord-010092-uftc8inx 7273 13 , , , cord-010092-uftc8inx 7273 14 unfrozen unfrozen JJ cord-010092-uftc8inx 7273 15 and and CC cord-010092-uftc8inx 7273 16 diluted dilute VBN cord-010092-uftc8inx 7273 17 with with IN cord-010092-uftc8inx 7273 18 NaCl nacl NN cord-010092-uftc8inx 7273 19 solution solution NN cord-010092-uftc8inx 7273 20 , , , cord-010092-uftc8inx 7273 21 up up IN cord-010092-uftc8inx 7273 22 to to TO cord-010092-uftc8inx 7273 23 30 30 CD cord-010092-uftc8inx 7273 24 % % NN cord-010092-uftc8inx 7273 25 . . . cord-010092-uftc8inx 7274 1 Auto auto NN cord-010092-uftc8inx 7274 2 SEDs sed NNS cord-010092-uftc8inx 7274 3 were be VBD cord-010092-uftc8inx 7274 4 administered administer VBN cord-010092-uftc8inx 7274 5 in in IN cord-010092-uftc8inx 7274 6 the the DT cord-010092-uftc8inx 7274 7 form form NN cord-010092-uftc8inx 7274 8 of of IN cord-010092-uftc8inx 7274 9 20 20 CD cord-010092-uftc8inx 7274 10 % % NN cord-010092-uftc8inx 7274 11 eye eye NN cord-010092-uftc8inx 7274 12 drops drop NNS cord-010092-uftc8inx 7274 13 . . . cord-010092-uftc8inx 7275 1 Results result NNS cord-010092-uftc8inx 7275 2 : : : cord-010092-uftc8inx 7276 1 Auto auto NN cord-010092-uftc8inx 7276 2 SEDs sed NNS cord-010092-uftc8inx 7276 3 have have VBP cord-010092-uftc8inx 7276 4 been be VBN cord-010092-uftc8inx 7276 5 applied apply VBN cord-010092-uftc8inx 7276 6 to to IN cord-010092-uftc8inx 7276 7 17 17 CD cord-010092-uftc8inx 7276 8 ophthalmological ophthalmological JJ cord-010092-uftc8inx 7276 9 patients patient NNS cord-010092-uftc8inx 7276 10 ( ( -LRB- cord-010092-uftc8inx 7276 11 10 10 CD cord-010092-uftc8inx 7276 12 men man NNS cord-010092-uftc8inx 7276 13 and and CC cord-010092-uftc8inx 7276 14 7 7 CD cord-010092-uftc8inx 7276 15 women woman NNS cord-010092-uftc8inx 7276 16 ) ) -RRB- cord-010092-uftc8inx 7276 17 , , , cord-010092-uftc8inx 7276 18 previously previously RB cord-010092-uftc8inx 7276 19 resistant resistant JJ cord-010092-uftc8inx 7276 20 to to IN cord-010092-uftc8inx 7276 21 standard standard JJ cord-010092-uftc8inx 7276 22 therapy therapy NN cord-010092-uftc8inx 7276 23 . . . cord-010092-uftc8inx 7277 1 In in IN cord-010092-uftc8inx 7277 2 total total JJ cord-010092-uftc8inx 7277 3 44 44 CD cord-010092-uftc8inx 7277 4 treatments treatment NNS cord-010092-uftc8inx 7277 5 were be VBD cord-010092-uftc8inx 7277 6 performed perform VBN cord-010092-uftc8inx 7277 7 ( ( -LRB- cord-010092-uftc8inx 7277 8 each each DT cord-010092-uftc8inx 7277 9 lasted last VBD cord-010092-uftc8inx 7277 10 20 20 CD cord-010092-uftc8inx 7277 11 days day NNS cord-010092-uftc8inx 7277 12 ) ) -RRB- cord-010092-uftc8inx 7277 13 . . . cord-010092-uftc8inx 7278 1 For for IN cord-010092-uftc8inx 7278 2 successful successful JJ cord-010092-uftc8inx 7278 3 curing curing NN cord-010092-uftc8inx 7278 4 , , , cord-010092-uftc8inx 7278 5 one one CD cord-010092-uftc8inx 7278 6 or or CC cord-010092-uftc8inx 7278 7 two two CD cord-010092-uftc8inx 7278 8 treatments treatment NNS cord-010092-uftc8inx 7278 9 per per IN cord-010092-uftc8inx 7278 10 patient patient NN cord-010092-uftc8inx 7278 11 , , , cord-010092-uftc8inx 7278 12 in in IN cord-010092-uftc8inx 7278 13 average average JJ cord-010092-uftc8inx 7278 14 , , , cord-010092-uftc8inx 7278 15 were be VBD cord-010092-uftc8inx 7278 16 applied apply VBN cord-010092-uftc8inx 7278 17 . . . cord-010092-uftc8inx 7279 1 APL APL NNP cord-010092-uftc8inx 7279 2 has have VBZ cord-010092-uftc8inx 7279 3 been be VBN cord-010092-uftc8inx 7279 4 used use VBN cord-010092-uftc8inx 7279 5 multiple multiple JJ cord-010092-uftc8inx 7279 6 times time NNS cord-010092-uftc8inx 7279 7 to to IN cord-010092-uftc8inx 7279 8 one one CD cord-010092-uftc8inx 7279 9 patient patient NN cord-010092-uftc8inx 7279 10 with with IN cord-010092-uftc8inx 7279 11 Sj€ Sj€ NNP cord-010092-uftc8inx 7279 12 ogren ogren NNP cord-010092-uftc8inx 7279 13 syndrome syndrome NN cord-010092-uftc8inx 7279 14 and and CC cord-010092-uftc8inx 7279 15 severe severe JJ cord-010092-uftc8inx 7279 16 multiple multiple JJ cord-010092-uftc8inx 7279 17 tropical tropical JJ cord-010092-uftc8inx 7279 18 corneal corneal JJ cord-010092-uftc8inx 7279 19 changes change NNS cord-010092-uftc8inx 7279 20 . . . cord-010092-uftc8inx 7280 1 All all DT cord-010092-uftc8inx 7280 2 ophthalmological ophthalmological JJ cord-010092-uftc8inx 7280 3 patients patient NNS cord-010092-uftc8inx 7280 4 had have VBD cord-010092-uftc8inx 7280 5 subjective subjective JJ cord-010092-uftc8inx 7280 6 improvements improvement NNS cord-010092-uftc8inx 7280 7 ( ( -LRB- cord-010092-uftc8inx 7280 8 the the DT cord-010092-uftc8inx 7280 9 average average JJ cord-010092-uftc8inx 7280 10 Pre Pre NNP cord-010092-uftc8inx 7280 11 and and CC cord-010092-uftc8inx 7280 12 Post Post NNP cord-010092-uftc8inx 7280 13 treatment treatment NN cord-010092-uftc8inx 7280 14 OSDI OSDI NNP cord-010092-uftc8inx 7280 15 scores score NNS cord-010092-uftc8inx 7280 16 were be VBD cord-010092-uftc8inx 7280 17 71.3 71.3 CD cord-010092-uftc8inx 7280 18 and and CC cord-010092-uftc8inx 7280 19 19.6 19.6 CD cord-010092-uftc8inx 7280 20 respectively respectively RB cord-010092-uftc8inx 7280 21 ) ) -RRB- cord-010092-uftc8inx 7280 22 . . . cord-010092-uftc8inx 7281 1 Also also RB cord-010092-uftc8inx 7281 2 , , , cord-010092-uftc8inx 7281 3 objective objective JJ cord-010092-uftc8inx 7281 4 progress progress NN cord-010092-uftc8inx 7281 5 was be VBD cord-010092-uftc8inx 7281 6 present present JJ cord-010092-uftc8inx 7281 7 in in IN cord-010092-uftc8inx 7281 8 83 83 CD cord-010092-uftc8inx 7281 9 % % NN cord-010092-uftc8inx 7281 10 of of IN cord-010092-uftc8inx 7281 11 all all DT cord-010092-uftc8inx 7281 12 patients patient NNS cord-010092-uftc8inx 7281 13 ( ( -LRB- cord-010092-uftc8inx 7281 14 P p NN cord-010092-uftc8inx 7281 15 < < XX cord-010092-uftc8inx 7281 16 0.001 0.001 CD cord-010092-uftc8inx 7281 17 ) ) -RRB- cord-010092-uftc8inx 7281 18 . . . cord-010092-uftc8inx 7282 1 Summary Summary NNP cord-010092-uftc8inx 7282 2 / / SYM cord-010092-uftc8inx 7282 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 7282 4 : : : cord-010092-uftc8inx 7283 1 The the DT cord-010092-uftc8inx 7283 2 use use NN cord-010092-uftc8inx 7283 3 of of IN cord-010092-uftc8inx 7283 4 Auto auto NN cord-010092-uftc8inx 7283 5 SEDs sed NNS cord-010092-uftc8inx 7283 6 and and CC cord-010092-uftc8inx 7283 7 APL APL NNP cord-010092-uftc8inx 7283 8 in in IN cord-010092-uftc8inx 7283 9 the the DT cord-010092-uftc8inx 7283 10 treatment treatment NN cord-010092-uftc8inx 7283 11 of of IN cord-010092-uftc8inx 7283 12 ophthalmological ophthalmological JJ cord-010092-uftc8inx 7283 13 patients patient NNS cord-010092-uftc8inx 7283 14 , , , cord-010092-uftc8inx 7283 15 previously previously RB cord-010092-uftc8inx 7283 16 resistant resistant JJ cord-010092-uftc8inx 7283 17 to to IN cord-010092-uftc8inx 7283 18 standard standard JJ cord-010092-uftc8inx 7283 19 therapy therapy NN cord-010092-uftc8inx 7283 20 , , , cord-010092-uftc8inx 7283 21 is be VBZ cord-010092-uftc8inx 7283 22 in in IN cord-010092-uftc8inx 7283 23 constant constant JJ cord-010092-uftc8inx 7283 24 increase increase NN cord-010092-uftc8inx 7283 25 , , , cord-010092-uftc8inx 7283 26 because because IN cord-010092-uftc8inx 7283 27 of of IN cord-010092-uftc8inx 7283 28 its -PRON- PRP$ cord-010092-uftc8inx 7283 29 simplicity simplicity NN cord-010092-uftc8inx 7283 30 and and CC cord-010092-uftc8inx 7283 31 low low JJ cord-010092-uftc8inx 7283 32 expenses expense NNS cord-010092-uftc8inx 7283 33 . . . cord-010092-uftc8inx 7284 1 APL APL NNP cord-010092-uftc8inx 7284 2 has have VBZ cord-010092-uftc8inx 7284 3 turned turn VBN cord-010092-uftc8inx 7284 4 out out RP cord-010092-uftc8inx 7284 5 to to TO cord-010092-uftc8inx 7284 6 be be VB cord-010092-uftc8inx 7284 7 better well JJR cord-010092-uftc8inx 7284 8 than than IN cord-010092-uftc8inx 7284 9 Auto auto NN cord-010092-uftc8inx 7284 10 SEDs sed NNS cord-010092-uftc8inx 7284 11 for for IN cord-010092-uftc8inx 7284 12 patients patient NNS cord-010092-uftc8inx 7284 13 with with IN cord-010092-uftc8inx 7284 14 severe severe JJ cord-010092-uftc8inx 7284 15 trophic trophic JJ cord-010092-uftc8inx 7284 16 changes change NNS cord-010092-uftc8inx 7284 17 , , , cord-010092-uftc8inx 7284 18 because because IN cord-010092-uftc8inx 7284 19 APL APL NNP cord-010092-uftc8inx 7284 20 contains contain VBZ cord-010092-uftc8inx 7284 21 larger large JJR cord-010092-uftc8inx 7284 22 amounts amount NNS cord-010092-uftc8inx 7284 23 of of IN cord-010092-uftc8inx 7284 24 the the DT cord-010092-uftc8inx 7284 25 Nerve Nerve NNP cord-010092-uftc8inx 7284 26 Growth Growth NNP cord-010092-uftc8inx 7284 27 Factor Factor NNP cord-010092-uftc8inx 7284 28 , , , cord-010092-uftc8inx 7284 29 TGF TGF NNP cord-010092-uftc8inx 7284 30 - - HYPH cord-010092-uftc8inx 7284 31 B B NNP cord-010092-uftc8inx 7284 32 , , , cord-010092-uftc8inx 7284 33 VEGF VEGF NNP cord-010092-uftc8inx 7284 34 and and CC cord-010092-uftc8inx 7284 35 Platelet platelet NN cord-010092-uftc8inx 7284 36 Derived derive VBD cord-010092-uftc8inx 7284 37 Growth Growth NNP cord-010092-uftc8inx 7284 38 Factor Factor NNP cord-010092-uftc8inx 7284 39 . . . cord-010092-uftc8inx 7285 1 However however RB cord-010092-uftc8inx 7285 2 , , , cord-010092-uftc8inx 7285 3 a a DT cord-010092-uftc8inx 7285 4 larger large JJR cord-010092-uftc8inx 7285 5 number number NN cord-010092-uftc8inx 7285 6 of of IN cord-010092-uftc8inx 7285 7 clinical clinical JJ cord-010092-uftc8inx 7285 8 cases case NNS cord-010092-uftc8inx 7285 9 is be VBZ cord-010092-uftc8inx 7285 10 needed need VBN cord-010092-uftc8inx 7285 11 for for IN cord-010092-uftc8inx 7285 12 future future JJ cord-010092-uftc8inx 7285 13 conclusions conclusion NNS cord-010092-uftc8inx 7285 14 . . . cord-010092-uftc8inx 7286 1 Background background NN cord-010092-uftc8inx 7286 2 : : : cord-010092-uftc8inx 7287 1 Whole whole JJ cord-010092-uftc8inx 7287 2 blood blood NN cord-010092-uftc8inx 7287 3 ( ( -LRB- cord-010092-uftc8inx 7287 4 WB WB NNP cord-010092-uftc8inx 7287 5 ) ) -RRB- cord-010092-uftc8inx 7287 6 has have VBZ cord-010092-uftc8inx 7287 7 recently recently RB cord-010092-uftc8inx 7287 8 regained regain VBN cord-010092-uftc8inx 7287 9 favor favor NN cord-010092-uftc8inx 7287 10 in in IN cord-010092-uftc8inx 7287 11 treatment treatment NN cord-010092-uftc8inx 7287 12 of of IN cord-010092-uftc8inx 7287 13 massively massively RB cord-010092-uftc8inx 7287 14 bleeding bleed VBG cord-010092-uftc8inx 7287 15 patients patient NNS cord-010092-uftc8inx 7287 16 in in IN cord-010092-uftc8inx 7287 17 military military JJ cord-010092-uftc8inx 7287 18 and and CC cord-010092-uftc8inx 7287 19 civilian civilian JJ cord-010092-uftc8inx 7287 20 settings setting NNS cord-010092-uftc8inx 7287 21 . . . cord-010092-uftc8inx 7288 1 1 1 LS cord-010092-uftc8inx 7288 2 Platelets platelet NNS cord-010092-uftc8inx 7288 3 ( ( -LRB- cord-010092-uftc8inx 7288 4 PLTs plt NNS cord-010092-uftc8inx 7288 5 ) ) -RRB- cord-010092-uftc8inx 7288 6 are be VBP cord-010092-uftc8inx 7288 7 a a DT cord-010092-uftc8inx 7288 8 vital vital JJ cord-010092-uftc8inx 7288 9 component component NN cord-010092-uftc8inx 7288 10 in in IN cord-010092-uftc8inx 7288 11 clot clot NN cord-010092-uftc8inx 7288 12 formation formation NN cord-010092-uftc8inx 7288 13 . . . cord-010092-uftc8inx 7289 1 As as IN cord-010092-uftc8inx 7289 2 a a DT cord-010092-uftc8inx 7289 3 component component NN cord-010092-uftc8inx 7289 4 of of IN cord-010092-uftc8inx 7289 5 WB WB NNP cord-010092-uftc8inx 7289 6 , , , cord-010092-uftc8inx 7289 7 it -PRON- PRP cord-010092-uftc8inx 7289 8 is be VBZ cord-010092-uftc8inx 7289 9 critical critical JJ cord-010092-uftc8inx 7289 10 that that IN cord-010092-uftc8inx 7289 11 they -PRON- PRP cord-010092-uftc8inx 7289 12 maintain maintain VBP cord-010092-uftc8inx 7289 13 functionality functionality NN cord-010092-uftc8inx 7289 14 throughout throughout IN cord-010092-uftc8inx 7289 15 storage storage NN cord-010092-uftc8inx 7289 16 . . . cord-010092-uftc8inx 7290 1 Red red JJ cord-010092-uftc8inx 7290 2 blood blood NN cord-010092-uftc8inx 7290 3 cells cell NNS cord-010092-uftc8inx 7290 4 ( ( -LRB- cord-010092-uftc8inx 7290 5 RBCs rbc NNS cord-010092-uftc8inx 7290 6 ) ) -RRB- cord-010092-uftc8inx 7290 7 stored store VBN cord-010092-uftc8inx 7290 8 in in IN cord-010092-uftc8inx 7290 9 hypoxic/ hypoxic/ JJ cord-010092-uftc8inx 7290 10 hypocapnic hypocapnic NNP cord-010092-uftc8inx 7290 11 conditions condition NNS cord-010092-uftc8inx 7290 12 preserve preserve VBP cord-010092-uftc8inx 7290 13 high high JJ cord-010092-uftc8inx 7290 14 level level NN cord-010092-uftc8inx 7290 15 of of IN cord-010092-uftc8inx 7290 16 2,3-DPG 2,3-dpg CD cord-010092-uftc8inx 7290 17 while while IN cord-010092-uftc8inx 7290 18 reducing reduce VBG cord-010092-uftc8inx 7290 19 storage storage NN cord-010092-uftc8inx 7290 20 lesions lesion NNS cord-010092-uftc8inx 7290 21 stemming stem VBG cord-010092-uftc8inx 7290 22 from from IN cord-010092-uftc8inx 7290 23 oxidative oxidative JJ cord-010092-uftc8inx 7290 24 stress stress NN cord-010092-uftc8inx 7290 25 . . . cord-010092-uftc8inx 7291 1 2 2 LS cord-010092-uftc8inx 7291 2 , , , cord-010092-uftc8inx 7291 3 3 3 CD cord-010092-uftc8inx 7291 4 On on IN cord-010092-uftc8inx 7291 5 the the DT cord-010092-uftc8inx 7291 6 other other JJ cord-010092-uftc8inx 7291 7 hand hand NN cord-010092-uftc8inx 7291 8 , , , cord-010092-uftc8inx 7291 9 effects effect NNS cord-010092-uftc8inx 7291 10 of of IN cord-010092-uftc8inx 7291 11 steady steady JJ cord-010092-uftc8inx 7291 12 hypoxia hypoxia NN cord-010092-uftc8inx 7291 13 ( ( -LRB- cord-010092-uftc8inx 7291 14 pCO2~10 pco2~10 RB cord-010092-uftc8inx 7291 15 - - HYPH cord-010092-uftc8inx 7291 16 20 20 CD cord-010092-uftc8inx 7291 17 mmHg mmHg NNS cord-010092-uftc8inx 7291 18 ) ) -RRB- cord-010092-uftc8inx 7291 19 on on IN cord-010092-uftc8inx 7291 20 PLTs plt NNS cord-010092-uftc8inx 7291 21 contained contain VBN cord-010092-uftc8inx 7291 22 in in IN cord-010092-uftc8inx 7291 23 leukoreduced leukoreduced JJ cord-010092-uftc8inx 7291 24 WB WB NNP cord-010092-uftc8inx 7291 25 is be VBZ cord-010092-uftc8inx 7291 26 poorly poorly RB cord-010092-uftc8inx 7291 27 characterized characterize VBN cord-010092-uftc8inx 7291 28 . . . cord-010092-uftc8inx 7292 1 Aims aim NNS cord-010092-uftc8inx 7292 2 : : : cord-010092-uftc8inx 7292 3 Examine examine VB cord-010092-uftc8inx 7292 4 the the DT cord-010092-uftc8inx 7292 5 effects effect NNS cord-010092-uftc8inx 7292 6 of of IN cord-010092-uftc8inx 7292 7 hypoxic hypoxic JJ cord-010092-uftc8inx 7292 8 conditions condition NNS cord-010092-uftc8inx 7292 9 on on IN cord-010092-uftc8inx 7292 10 PLT PLT NNP cord-010092-uftc8inx 7292 11 function function NN cord-010092-uftc8inx 7292 12 and and CC cord-010092-uftc8inx 7292 13 microvesicle microvesicle NNP cord-010092-uftc8inx 7292 14 ( ( -LRB- cord-010092-uftc8inx 7292 15 MV MV NNP cord-010092-uftc8inx 7292 16 ) ) -RRB- cord-010092-uftc8inx 7292 17 formation formation NN cord-010092-uftc8inx 7292 18 in in IN cord-010092-uftc8inx 7292 19 WB WB NNP cord-010092-uftc8inx 7292 20 stored store VBN cord-010092-uftc8inx 7292 21 hypoxically hypoxically RB cord-010092-uftc8inx 7292 22 ( ( -LRB- cord-010092-uftc8inx 7292 23 H h NN cord-010092-uftc8inx 7292 24 ) ) -RRB- cord-010092-uftc8inx 7292 25 and and CC cord-010092-uftc8inx 7292 26 conventionally conventionally RB cord-010092-uftc8inx 7292 27 ( ( -LRB- cord-010092-uftc8inx 7292 28 C C NNP cord-010092-uftc8inx 7292 29 ) ) -RRB- cord-010092-uftc8inx 7292 30 for for IN cord-010092-uftc8inx 7292 31 3-week 3-week CD cord-010092-uftc8inx 7292 32 storage storage NN cord-010092-uftc8inx 7292 33 at at IN cord-010092-uftc8inx 7292 34 1 1 CD cord-010092-uftc8inx 7292 35 - - SYM cord-010092-uftc8inx 7292 36 6 6 CD cord-010092-uftc8inx 7292 37 ° ° NN cord-010092-uftc8inx 7292 38 C c NN cord-010092-uftc8inx 7292 39 . . . cord-010092-uftc8inx 7293 1 Methods method NNS cord-010092-uftc8inx 7293 2 : : : cord-010092-uftc8inx 7293 3 11 11 CD cord-010092-uftc8inx 7293 4 units unit NNS cord-010092-uftc8inx 7293 5 of of IN cord-010092-uftc8inx 7293 6 WB WB NNP cord-010092-uftc8inx 7293 7 were be VBD cord-010092-uftc8inx 7293 8 collected collect VBN cord-010092-uftc8inx 7293 9 at at IN cord-010092-uftc8inx 7293 10 Mayo Mayo NNP cord-010092-uftc8inx 7293 11 Clinic Clinic NNP cord-010092-uftc8inx 7293 12 Rochester Rochester NNP cord-010092-uftc8inx 7293 13 Blood Blood NNP cord-010092-uftc8inx 7293 14 Donor Donor NNP cord-010092-uftc8inx 7293 15 Center Center NNP cord-010092-uftc8inx 7293 16 from from IN cord-010092-uftc8inx 7293 17 normal normal JJ cord-010092-uftc8inx 7293 18 healthy healthy JJ cord-010092-uftc8inx 7293 19 volunteers volunteer NNS cord-010092-uftc8inx 7293 20 into into IN cord-010092-uftc8inx 7293 21 70 70 CD cord-010092-uftc8inx 7293 22 mL mL NNP cord-010092-uftc8inx 7293 23 CP2D. CP2D. NNP cord-010092-uftc8inx 7293 24 WB WB NNP cord-010092-uftc8inx 7293 25 was be VBD cord-010092-uftc8inx 7293 26 leukoreduced leukoreduce VBN cord-010092-uftc8inx 7293 27 using use VBG cord-010092-uftc8inx 7293 28 PLT PLT NNP cord-010092-uftc8inx 7293 29 - - HYPH cord-010092-uftc8inx 7293 30 sparing spare VBG cord-010092-uftc8inx 7293 31 filter filter NN cord-010092-uftc8inx 7293 32 ( ( -LRB- cord-010092-uftc8inx 7293 33 Terumo Terumo NNP cord-010092-uftc8inx 7293 34 WB WB NNP cord-010092-uftc8inx 7293 35 - - HYPH cord-010092-uftc8inx 7293 36 S S NNP cord-010092-uftc8inx 7293 37 ) ) -RRB- cord-010092-uftc8inx 7293 38 then then RB cord-010092-uftc8inx 7293 39 split split VBD cord-010092-uftc8inx 7293 40 into into IN cord-010092-uftc8inx 7293 41 Control Control NNP cord-010092-uftc8inx 7293 42 ( ( -LRB- cord-010092-uftc8inx 7293 43 C C NNP cord-010092-uftc8inx 7293 44 ) ) -RRB- cord-010092-uftc8inx 7293 45 and and CC cord-010092-uftc8inx 7293 46 Hypoxic hypoxic JJ cord-010092-uftc8inx 7293 47 ( ( -LRB- cord-010092-uftc8inx 7293 48 H H NNP cord-010092-uftc8inx 7293 49 ) ) -RRB- cord-010092-uftc8inx 7293 50 . . . cord-010092-uftc8inx 7294 1 H H NNP cord-010092-uftc8inx 7294 2 - - HYPH cord-010092-uftc8inx 7294 3 WB WB NNP cord-010092-uftc8inx 7294 4 was be VBD cord-010092-uftc8inx 7294 5 processed process VBN cord-010092-uftc8inx 7294 6 by by IN cord-010092-uftc8inx 7294 7 the the DT cord-010092-uftc8inx 7294 8 oxygen oxygen NN cord-010092-uftc8inx 7294 9 - - HYPH cord-010092-uftc8inx 7294 10 reduction reduction NN cord-010092-uftc8inx 7294 11 bag bag NN cord-010092-uftc8inx 7294 12 ( ( -LRB- cord-010092-uftc8inx 7294 13 Hemanext Hemanext NNP cord-010092-uftc8inx 7294 14 , , , cord-010092-uftc8inx 7294 15 Lexington Lexington NNP cord-010092-uftc8inx 7294 16 MA MA NNP cord-010092-uftc8inx 7294 17 ) ) -RRB- cord-010092-uftc8inx 7294 18 and and CC cord-010092-uftc8inx 7294 19 unit unit NN cord-010092-uftc8inx 7294 20 was be VBD cord-010092-uftc8inx 7294 21 stored store VBN cord-010092-uftc8inx 7294 22 in in IN cord-010092-uftc8inx 7294 23 O2-free o2-free NN cord-010092-uftc8inx 7294 24 bag bag NN cord-010092-uftc8inx 7294 25 . . . cord-010092-uftc8inx 7295 1 5 5 CD cord-010092-uftc8inx 7295 2 mL ml NN cord-010092-uftc8inx 7295 3 of of IN cord-010092-uftc8inx 7295 4 WB WB NNP cord-010092-uftc8inx 7295 5 were be VBD cord-010092-uftc8inx 7295 6 collected collect VBN cord-010092-uftc8inx 7295 7 from from IN cord-010092-uftc8inx 7295 8 each each DT cord-010092-uftc8inx 7295 9 unit unit NN cord-010092-uftc8inx 7295 10 at at IN cord-010092-uftc8inx 7295 11 day day NN cord-010092-uftc8inx 7295 12 1 1 CD cord-010092-uftc8inx 7295 13 , , , cord-010092-uftc8inx 7295 14 weeks week NNS cord-010092-uftc8inx 7295 15 1 1 CD cord-010092-uftc8inx 7295 16 , , , cord-010092-uftc8inx 7295 17 2 2 CD cord-010092-uftc8inx 7295 18 , , , cord-010092-uftc8inx 7295 19 3 3 CD cord-010092-uftc8inx 7295 20 . . . cord-010092-uftc8inx 7296 1 PLT PLT NNP cord-010092-uftc8inx 7296 2 counts count VBZ cord-010092-uftc8inx 7296 3 , , , cord-010092-uftc8inx 7296 4 agonists agonist NNS cord-010092-uftc8inx 7296 5 ( ( -LRB- cord-010092-uftc8inx 7296 6 thrombin thrombin JJ cord-010092-uftc8inx 7296 7 receptor receptor NN cord-010092-uftc8inx 7296 8 agonist agonist NN cord-010092-uftc8inx 7296 9 peptide peptide NN cord-010092-uftc8inx 7296 10 ( ( -LRB- cord-010092-uftc8inx 7296 11 TRAP TRAP NNP cord-010092-uftc8inx 7296 12 ) ) -RRB- cord-010092-uftc8inx 7296 13 , , , cord-010092-uftc8inx 7296 14 adenosine adenosine NN cord-010092-uftc8inx 7296 15 diphosphate diphosphate NN cord-010092-uftc8inx 7296 16 ( ( -LRB- cord-010092-uftc8inx 7296 17 ADP ADP NNP cord-010092-uftc8inx 7296 18 ) ) -RRB- cord-010092-uftc8inx 7296 19 and and CC cord-010092-uftc8inx 7296 20 collagen collagen NN cord-010092-uftc8inx 7296 21 stimulated stimulate VBD cord-010092-uftc8inx 7296 22 platelets platelet NNS cord-010092-uftc8inx 7296 23 aggregation aggregation NN cord-010092-uftc8inx 7296 24 , , , cord-010092-uftc8inx 7296 25 nonactivated nonactivate VBN cord-010092-uftc8inx 7296 26 and and CC cord-010092-uftc8inx 7296 27 agonists agonist NNS cord-010092-uftc8inx 7296 28 activated activate VBD cord-010092-uftc8inx 7296 29 PLT PLT NNP cord-010092-uftc8inx 7296 30 surface surface NN cord-010092-uftc8inx 7296 31 expression expression NN cord-010092-uftc8inx 7296 32 of of IN cord-010092-uftc8inx 7296 33 phosphatidylserine phosphatidylserine NN cord-010092-uftc8inx 7296 34 ( ( -LRB- cord-010092-uftc8inx 7296 35 PS PS NNP cord-010092-uftc8inx 7296 36 , , , cord-010092-uftc8inx 7296 37 annexin annexin NN cord-010092-uftc8inx 7296 38 - - HYPH cord-010092-uftc8inx 7296 39 V v NN cord-010092-uftc8inx 7296 40 binding binding NN cord-010092-uftc8inx 7296 41 ) ) -RRB- cord-010092-uftc8inx 7296 42 , , , cord-010092-uftc8inx 7296 43 P p NN cord-010092-uftc8inx 7296 44 - - HYPH cord-010092-uftc8inx 7296 45 selectin selectin NNP cord-010092-uftc8inx 7296 46 , , , cord-010092-uftc8inx 7296 47 fibrinogen fibrinogen NN cord-010092-uftc8inx 7296 48 receptor receptor NN cord-010092-uftc8inx 7296 49 ( ( -LRB- cord-010092-uftc8inx 7296 50 PAC-1 pac-1 RB cord-010092-uftc8inx 7296 51 binding bind VBG cord-010092-uftc8inx 7296 52 ) ) -RRB- cord-010092-uftc8inx 7296 53 , , , cord-010092-uftc8inx 7296 54 and and CC cord-010092-uftc8inx 7296 55 microvesicles microvesicles NNP cord-010092-uftc8inx 7296 56 ( ( -LRB- cord-010092-uftc8inx 7296 57 MV MV NNP cord-010092-uftc8inx 7296 58 ) ) -RRB- cord-010092-uftc8inx 7296 59 were be VBD cord-010092-uftc8inx 7296 60 measured measure VBN cord-010092-uftc8inx 7296 61 by by IN cord-010092-uftc8inx 7296 62 Coulter Coulter NNP cord-010092-uftc8inx 7296 63 counter counter NN cord-010092-uftc8inx 7296 64 and and CC cord-010092-uftc8inx 7296 65 digital digital JJ cord-010092-uftc8inx 7296 66 flow flow NN cord-010092-uftc8inx 7296 67 cytometer cytometer NN cord-010092-uftc8inx 7296 68 . . . cord-010092-uftc8inx 7297 1 Paired Paired NNP cord-010092-uftc8inx 7297 2 Student Student NNP cord-010092-uftc8inx 7297 3 t t NN cord-010092-uftc8inx 7297 4 - - HYPH cord-010092-uftc8inx 7297 5 tests test NNS cord-010092-uftc8inx 7297 6 were be VBD cord-010092-uftc8inx 7297 7 used use VBN cord-010092-uftc8inx 7297 8 to to IN cord-010092-uftc8inx 7297 9 analyzed analyze VBN cord-010092-uftc8inx 7297 10 differences difference NNS cord-010092-uftc8inx 7297 11 in in IN cord-010092-uftc8inx 7297 12 degradation degradation NN cord-010092-uftc8inx 7297 13 rates rate NNS cord-010092-uftc8inx 7297 14 ; ; : cord-010092-uftc8inx 7297 15 significance significance NN cord-010092-uftc8inx 7297 16 : : : cord-010092-uftc8inx 7297 17 P p NN cord-010092-uftc8inx 7297 18 < < XX cord-010092-uftc8inx 7297 19 0.05 0.05 CD cord-010092-uftc8inx 7297 20 . . . cord-010092-uftc8inx 7298 1 Results result NNS cord-010092-uftc8inx 7298 2 : : : cord-010092-uftc8inx 7299 1 H H NNP cord-010092-uftc8inx 7299 2 - - HYPH cord-010092-uftc8inx 7299 3 PLT PLT NNP cord-010092-uftc8inx 7299 4 counts count NNS cord-010092-uftc8inx 7299 5 declined decline VBD cord-010092-uftc8inx 7299 6 to~60 to~60 NNP cord-010092-uftc8inx 7299 7 % % NN cord-010092-uftc8inx 7299 8 by by IN cord-010092-uftc8inx 7299 9 the the DT cord-010092-uftc8inx 7299 10 O2-reduction o2-reduction NN cord-010092-uftc8inx 7299 11 process process NN cord-010092-uftc8inx 7299 12 , , , cord-010092-uftc8inx 7299 13 while while IN cord-010092-uftc8inx 7299 14 similar similar JJ cord-010092-uftc8inx 7299 15 decline decline NN cord-010092-uftc8inx 7299 16 was be VBD cord-010092-uftc8inx 7299 17 observed observe VBN cord-010092-uftc8inx 7299 18 after after IN cord-010092-uftc8inx 7299 19 1 1 CD cord-010092-uftc8inx 7299 20 week week NN cord-010092-uftc8inx 7299 21 in in IN cord-010092-uftc8inx 7299 22 C C NNP cord-010092-uftc8inx 7299 23 , , , cord-010092-uftc8inx 7299 24 and and CC cord-010092-uftc8inx 7299 25 thereafter thereafter RB cord-010092-uftc8inx 7299 26 remained remain VBD cord-010092-uftc8inx 7299 27 steady steady JJ cord-010092-uftc8inx 7299 28 . . . cord-010092-uftc8inx 7300 1 PLT PLT NNP cord-010092-uftc8inx 7300 2 activation activation NN cord-010092-uftc8inx 7300 3 ( ( -LRB- cord-010092-uftc8inx 7300 4 PS PS NNP cord-010092-uftc8inx 7300 5 ) ) -RRB- cord-010092-uftc8inx 7300 6 increased increase VBD cord-010092-uftc8inx 7300 7 over over IN cord-010092-uftc8inx 7300 8 time time NN cord-010092-uftc8inx 7300 9 ( ( -LRB- cord-010092-uftc8inx 7300 10 H h NN cord-010092-uftc8inx 7300 11 > > XX cord-010092-uftc8inx 7301 1 > > XX cord-010092-uftc8inx 7302 1 C c NN cord-010092-uftc8inx 7302 2 after after IN cord-010092-uftc8inx 7302 3 processing processing NN cord-010092-uftc8inx 7302 4 ; ; : cord-010092-uftc8inx 7302 5 C C NNP cord-010092-uftc8inx 7302 6 increasing increase VBG cord-010092-uftc8inx 7302 7 more more RBR cord-010092-uftc8inx 7302 8 rapidly rapidly RB cord-010092-uftc8inx 7302 9 during during IN cord-010092-uftc8inx 7302 10 storage storage NN cord-010092-uftc8inx 7302 11 ) ) -RRB- cord-010092-uftc8inx 7302 12 . . . cord-010092-uftc8inx 7303 1 P p NN cord-010092-uftc8inx 7303 2 - - HYPH cord-010092-uftc8inx 7303 3 selectin selectin NNP cord-010092-uftc8inx 7303 4 increased increase VBD cord-010092-uftc8inx 7303 5 over over IN cord-010092-uftc8inx 7303 6 time time NN cord-010092-uftc8inx 7303 7 ( ( -LRB- cord-010092-uftc8inx 7303 8 H h NN cord-010092-uftc8inx 7303 9 < < XX cord-010092-uftc8inx 7303 10 C C NNP cord-010092-uftc8inx 7303 11 ) ) -RRB- cord-010092-uftc8inx 7303 12 , , , cord-010092-uftc8inx 7303 13 while while IN cord-010092-uftc8inx 7303 14 PAC-1 PAC-1 NNS cord-010092-uftc8inx 7303 15 showed show VBD cord-010092-uftc8inx 7303 16 large large JJ cord-010092-uftc8inx 7303 17 increase increase NN cord-010092-uftc8inx 7303 18 after after IN cord-010092-uftc8inx 7303 19 1 1 CD cord-010092-uftc8inx 7303 20 week week NN cord-010092-uftc8inx 7303 21 , , , cord-010092-uftc8inx 7303 22 then then RB cord-010092-uftc8inx 7303 23 remained remain VBD cord-010092-uftc8inx 7303 24 steady steady JJ cord-010092-uftc8inx 7303 25 ( ( -LRB- cord-010092-uftc8inx 7303 26 H h NN cord-010092-uftc8inx 7303 27 < < XX cord-010092-uftc8inx 7303 28 < < XX cord-010092-uftc8inx 7303 29 C C NNP cord-010092-uftc8inx 7303 30 ) ) -RRB- cord-010092-uftc8inx 7303 31 . . . cord-010092-uftc8inx 7304 1 PLT PLT NNP cord-010092-uftc8inx 7304 2 activation activation NN cord-010092-uftc8inx 7304 3 by by IN cord-010092-uftc8inx 7304 4 TRAP trap NN cord-010092-uftc8inx 7304 5 or or CC cord-010092-uftc8inx 7304 6 ADP ADP NNP cord-010092-uftc8inx 7304 7 declined decline VBD cord-010092-uftc8inx 7304 8 modestly modestly RB cord-010092-uftc8inx 7304 9 over over IN cord-010092-uftc8inx 7304 10 3 3 CD cord-010092-uftc8inx 7304 11 weeks week NNS cord-010092-uftc8inx 7304 12 ( ( -LRB- cord-010092-uftc8inx 7304 13 ~15 ~15 NFP cord-010092-uftc8inx 7304 14 % % NN cord-010092-uftc8inx 7304 15 ) ) -RRB- cord-010092-uftc8inx 7304 16 while while IN cord-010092-uftc8inx 7304 17 H H NNP cord-010092-uftc8inx 7304 18 - - HYPH cord-010092-uftc8inx 7304 19 PLT PLT NNP cord-010092-uftc8inx 7304 20 showed show VBD cord-010092-uftc8inx 7304 21 additional~10 additional~10 NNP cord-010092-uftc8inx 7304 22 % % NN cord-010092-uftc8inx 7304 23 reduction reduction NN cord-010092-uftc8inx 7304 24 for for IN cord-010092-uftc8inx 7304 25 all all DT cord-010092-uftc8inx 7304 26 time time NN cord-010092-uftc8inx 7304 27 points point NNS cord-010092-uftc8inx 7304 28 . . . cord-010092-uftc8inx 7305 1 Collagen collagen NN cord-010092-uftc8inx 7305 2 activation activation NN cord-010092-uftc8inx 7305 3 for for IN cord-010092-uftc8inx 7305 4 C C NNP cord-010092-uftc8inx 7305 5 - - HYPH cord-010092-uftc8inx 7305 6 PLT PLT NNP cord-010092-uftc8inx 7305 7 increased increase VBD cord-010092-uftc8inx 7305 8 after after IN cord-010092-uftc8inx 7305 9 1 1 CD cord-010092-uftc8inx 7305 10 week week NN cord-010092-uftc8inx 7305 11 ( ( -LRB- cord-010092-uftc8inx 7305 12 74 74 CD cord-010092-uftc8inx 7305 13 % % NN cord-010092-uftc8inx 7305 14 ) ) -RRB- cord-010092-uftc8inx 7305 15 and and CC cord-010092-uftc8inx 7305 16 gradually gradually RB cord-010092-uftc8inx 7305 17 increased increase VBD cord-010092-uftc8inx 7305 18 to to IN cord-010092-uftc8inx 7305 19 100 100 CD cord-010092-uftc8inx 7305 20 % % NN cord-010092-uftc8inx 7305 21 after after IN cord-010092-uftc8inx 7305 22 3 3 CD cord-010092-uftc8inx 7305 23 weeks week NNS cord-010092-uftc8inx 7305 24 ( ( -LRB- cord-010092-uftc8inx 7305 25 ~20 ~20 NFP cord-010092-uftc8inx 7305 26 % % NN cord-010092-uftc8inx 7305 27 reduction reduction NN cord-010092-uftc8inx 7305 28 with with IN cord-010092-uftc8inx 7305 29 H h NN cord-010092-uftc8inx 7305 30 compared compare VBN cord-010092-uftc8inx 7305 31 to to IN cord-010092-uftc8inx 7305 32 C C NNP cord-010092-uftc8inx 7305 33 ) ) -RRB- cord-010092-uftc8inx 7305 34 . . . cord-010092-uftc8inx 7306 1 PLT PLT NNP cord-010092-uftc8inx 7306 2 - - HYPH cord-010092-uftc8inx 7306 3 derived derive VBN cord-010092-uftc8inx 7306 4 MV MV NNP cord-010092-uftc8inx 7307 1 ( ( -LRB- cord-010092-uftc8inx 7307 2 CD61 CD61 NNP cord-010092-uftc8inx 7307 3 and and CC cord-010092-uftc8inx 7307 4 CD61 CD61 NNP cord-010092-uftc8inx 7307 5 / / SYM cord-010092-uftc8inx 7307 6 Annexin Annexin NNP cord-010092-uftc8inx 7307 7 V V NNP cord-010092-uftc8inx 7307 8 ) ) -RRB- cord-010092-uftc8inx 7307 9 increased~4-fold increased~4-fold IN cord-010092-uftc8inx 7307 10 over over IN cord-010092-uftc8inx 7307 11 storage storage NN cord-010092-uftc8inx 7307 12 time time NN cord-010092-uftc8inx 7307 13 ; ; : cord-010092-uftc8inx 7307 14 Day day NN cord-010092-uftc8inx 7307 15 0 0 CD cord-010092-uftc8inx 7307 16 MV MV NNP cord-010092-uftc8inx 7307 17 levers lever NNS cord-010092-uftc8inx 7307 18 were be VBD cord-010092-uftc8inx 7307 19 significantly significantly RB cord-010092-uftc8inx 7307 20 higher high JJR cord-010092-uftc8inx 7307 21 for for IN cord-010092-uftc8inx 7307 22 H H NNP cord-010092-uftc8inx 7307 23 , , , cord-010092-uftc8inx 7307 24 but but CC cord-010092-uftc8inx 7307 25 subsequent subsequent JJ cord-010092-uftc8inx 7307 26 increase increase NN cord-010092-uftc8inx 7307 27 rates rate NNS cord-010092-uftc8inx 7307 28 were be VBD cord-010092-uftc8inx 7307 29 similar similar JJ cord-010092-uftc8inx 7307 30 or or CC cord-010092-uftc8inx 7307 31 lower low JJR cord-010092-uftc8inx 7307 32 . . . cord-010092-uftc8inx 7308 1 Total total JJ cord-010092-uftc8inx 7308 2 number number NN cord-010092-uftc8inx 7308 3 of of IN cord-010092-uftc8inx 7308 4 PLT PLT NNP cord-010092-uftc8inx 7308 5 - - HYPH cord-010092-uftc8inx 7308 6 derived derive VBN cord-010092-uftc8inx 7308 7 MV MV NNP cord-010092-uftc8inx 7308 8 ( ( -LRB- cord-010092-uftc8inx 7308 9 CD42a CD42a NNP cord-010092-uftc8inx 7308 10 ) ) -RRB- cord-010092-uftc8inx 7308 11 in in IN cord-010092-uftc8inx 7308 12 WB WB NNP cord-010092-uftc8inx 7308 13 supernatant supernatant NN cord-010092-uftc8inx 7308 14 increased increase VBD cord-010092-uftc8inx 7308 15 17-fold 17-fold RB cord-010092-uftc8inx 7308 16 after after IN cord-010092-uftc8inx 7308 17 3 3 CD cord-010092-uftc8inx 7308 18 weeks week NNS cord-010092-uftc8inx 7308 19 for for IN cord-010092-uftc8inx 7308 20 C C NNP cord-010092-uftc8inx 7308 21 , , , cord-010092-uftc8inx 7308 22 while while IN cord-010092-uftc8inx 7308 23 H H NNP cord-010092-uftc8inx 7308 24 suppressed suppress VBD cord-010092-uftc8inx 7308 25 increase increase NN cord-010092-uftc8inx 7308 26 to to IN cord-010092-uftc8inx 7308 27 7-fold 7-fold CD cord-010092-uftc8inx 7308 28 . . . cord-010092-uftc8inx 7309 1 ( ( -LRB- cord-010092-uftc8inx 7309 2 Majority majority NN cord-010092-uftc8inx 7309 3 of of IN cord-010092-uftc8inx 7309 4 the the DT cord-010092-uftc8inx 7309 5 trends trend NNS cord-010092-uftc8inx 7309 6 described describe VBN cord-010092-uftc8inx 7309 7 above above RB cord-010092-uftc8inx 7309 8 showed show VBD cord-010092-uftc8inx 7309 9 significant significant JJ cord-010092-uftc8inx 7309 10 differences difference NNS cord-010092-uftc8inx 7309 11 between between IN cord-010092-uftc8inx 7309 12 H H NNP cord-010092-uftc8inx 7309 13 and and CC cord-010092-uftc8inx 7309 14 C. C. NNP cord-010092-uftc8inx 7309 15 ) ) -RRB- cord-010092-uftc8inx 7310 1 Summary Summary NNP cord-010092-uftc8inx 7310 2 / / SYM cord-010092-uftc8inx 7310 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 7310 4 : : : cord-010092-uftc8inx 7311 1 PLTs plt NNS cord-010092-uftc8inx 7311 2 were be VBD cord-010092-uftc8inx 7311 3 activated activate VBN cord-010092-uftc8inx 7311 4 over over IN cord-010092-uftc8inx 7311 5 3-week 3-week CD cord-010092-uftc8inx 7311 6 period period NN cord-010092-uftc8inx 7311 7 when when WRB cord-010092-uftc8inx 7311 8 stored store VBN cord-010092-uftc8inx 7311 9 at at IN cord-010092-uftc8inx 7311 10 1 1 CD cord-010092-uftc8inx 7311 11 - - SYM cord-010092-uftc8inx 7311 12 6 6 CD cord-010092-uftc8inx 7311 13 ° ° NN cord-010092-uftc8inx 7311 14 C c NN cord-010092-uftc8inx 7311 15 in in IN cord-010092-uftc8inx 7311 16 leukoreduced leukoreduced JJ cord-010092-uftc8inx 7311 17 WB WB NNP cord-010092-uftc8inx 7311 18 , , , cord-010092-uftc8inx 7311 19 accompanied accompany VBN cord-010092-uftc8inx 7311 20 by by IN cord-010092-uftc8inx 7311 21 a a DT cord-010092-uftc8inx 7311 22 modest modest JJ cord-010092-uftc8inx 7311 23 loss loss NN cord-010092-uftc8inx 7311 24 of of IN cord-010092-uftc8inx 7311 25 agonist agonist NN cord-010092-uftc8inx 7311 26 - - HYPH cord-010092-uftc8inx 7311 27 induced induce VBN cord-010092-uftc8inx 7311 28 activation activation NN cord-010092-uftc8inx 7311 29 . . . cord-010092-uftc8inx 7312 1 Oxygen oxygen NN cord-010092-uftc8inx 7312 2 reduction reduction NN cord-010092-uftc8inx 7312 3 treatment treatment NN cord-010092-uftc8inx 7312 4 initially initially RB cord-010092-uftc8inx 7312 5 activated activate VBD cord-010092-uftc8inx 7312 6 H H NNP cord-010092-uftc8inx 7312 7 - - HYPH cord-010092-uftc8inx 7312 8 PLTs PLTs NNP cord-010092-uftc8inx 7312 9 , , , cord-010092-uftc8inx 7312 10 while while IN cord-010092-uftc8inx 7312 11 subsequent subsequent JJ cord-010092-uftc8inx 7312 12 increase increase NN cord-010092-uftc8inx 7312 13 in in IN cord-010092-uftc8inx 7312 14 activation activation NN cord-010092-uftc8inx 7312 15 rates rate NNS cord-010092-uftc8inx 7312 16 were be VBD cord-010092-uftc8inx 7312 17 suppressed suppress VBN cord-010092-uftc8inx 7312 18 compared compare VBN cord-010092-uftc8inx 7312 19 to to IN cord-010092-uftc8inx 7312 20 C C NNP cord-010092-uftc8inx 7312 21 - - HYPH cord-010092-uftc8inx 7312 22 PLTs PLTs NNP cord-010092-uftc8inx 7312 23 . . . cord-010092-uftc8inx 7313 1 WB WB NNP cord-010092-uftc8inx 7313 2 PLTs plt NNS cord-010092-uftc8inx 7313 3 retained retain VBD cord-010092-uftc8inx 7313 4 activatability activatability NN cord-010092-uftc8inx 7313 5 , , , cord-010092-uftc8inx 7313 6 and and CC cord-010092-uftc8inx 7313 7 hypoxic hypoxic JJ cord-010092-uftc8inx 7313 8 condition condition NN cord-010092-uftc8inx 7313 9 showed show VBD cord-010092-uftc8inx 7313 10 only only RB cord-010092-uftc8inx 7313 11 modest modest JJ cord-010092-uftc8inx 7313 12 further further JJ cord-010092-uftc8inx 7313 13 reduction reduction NN cord-010092-uftc8inx 7313 14 on on IN cord-010092-uftc8inx 7313 15 the the DT cord-010092-uftc8inx 7313 16 activatability activatability NN cord-010092-uftc8inx 7313 17 . . . cord-010092-uftc8inx 7314 1 Hypoxic hypoxic JJ cord-010092-uftc8inx 7314 2 WB WB NNP cord-010092-uftc8inx 7314 3 may may MD cord-010092-uftc8inx 7314 4 provide provide VB cord-010092-uftc8inx 7314 5 higher high JJR cord-010092-uftc8inx 7314 6 quality quality NN cord-010092-uftc8inx 7314 7 WB WB NNP cord-010092-uftc8inx 7314 8 for for IN cord-010092-uftc8inx 7314 9 trauma trauma NN cord-010092-uftc8inx 7314 10 patients patient NNS cord-010092-uftc8inx 7314 11 if if IN cord-010092-uftc8inx 7314 12 the the DT cord-010092-uftc8inx 7314 13 levels level NNS cord-010092-uftc8inx 7314 14 of of IN cord-010092-uftc8inx 7314 15 initial initial JJ cord-010092-uftc8inx 7314 16 PLT PLT NNP cord-010092-uftc8inx 7314 17 activation activation NN cord-010092-uftc8inx 7314 18 can can MD cord-010092-uftc8inx 7314 19 improved improve VBN cord-010092-uftc8inx 7314 20 during during IN cord-010092-uftc8inx 7314 21 oxygen oxygen NN cord-010092-uftc8inx 7314 22 reduction reduction NN cord-010092-uftc8inx 7314 23 procedure procedure NN cord-010092-uftc8inx 7314 24 . . . cord-010092-uftc8inx 7315 1 Methods method NNS cord-010092-uftc8inx 7315 2 : : : cord-010092-uftc8inx 7315 3 After after IN cord-010092-uftc8inx 7315 4 informed informed JJ cord-010092-uftc8inx 7315 5 consent consent NN cord-010092-uftc8inx 7315 6 , , , cord-010092-uftc8inx 7315 7 eligible eligible JJ cord-010092-uftc8inx 7315 8 patients patient NNS cord-010092-uftc8inx 7315 9 were be VBD cord-010092-uftc8inx 7315 10 randomized randomize VBN cord-010092-uftc8inx 7315 11 to to IN cord-010092-uftc8inx 7315 12 either either DT cord-010092-uftc8inx 7315 13 first first RB cord-010092-uftc8inx 7315 14 receive receive VB cord-010092-uftc8inx 7315 15 autologous autologous JJ cord-010092-uftc8inx 7315 16 followed follow VBN cord-010092-uftc8inx 7315 17 by by IN cord-010092-uftc8inx 7315 18 allogeneic allogeneic NN cord-010092-uftc8inx 7315 19 SEDs sed NNS cord-010092-uftc8inx 7315 20 or or CC cord-010092-uftc8inx 7315 21 first first RB cord-010092-uftc8inx 7315 22 receive receive VB cord-010092-uftc8inx 7315 23 allogeneic allogeneic NN cord-010092-uftc8inx 7315 24 followed follow VBN cord-010092-uftc8inx 7315 25 by by IN cord-010092-uftc8inx 7315 26 autologous autologous JJ cord-010092-uftc8inx 7315 27 SEDs sed NNS cord-010092-uftc8inx 7315 28 . . . cord-010092-uftc8inx 7316 1 Each each DT cord-010092-uftc8inx 7316 2 SED sed NN cord-010092-uftc8inx 7316 3 treatment treatment NN cord-010092-uftc8inx 7316 4 phase phase NN cord-010092-uftc8inx 7316 5 was be VBD cord-010092-uftc8inx 7316 6 one one CD cord-010092-uftc8inx 7316 7 month month NN cord-010092-uftc8inx 7316 8 , , , cord-010092-uftc8inx 7316 9 separated separate VBN cord-010092-uftc8inx 7316 10 by by IN cord-010092-uftc8inx 7316 11 one one CD cord-010092-uftc8inx 7316 12 month month NN cord-010092-uftc8inx 7316 13 of of IN cord-010092-uftc8inx 7316 14 patient patient NN cord-010092-uftc8inx 7316 15 's 's POS cord-010092-uftc8inx 7316 16 standard standard JJ cord-010092-uftc8inx 7316 17 treatment treatment NN cord-010092-uftc8inx 7316 18 ( ( -LRB- cord-010092-uftc8inx 7316 19 wash wash VB cord-010092-uftc8inx 7316 20 out out RP cord-010092-uftc8inx 7316 21 period period NN cord-010092-uftc8inx 7316 22 ) ) -RRB- cord-010092-uftc8inx 7316 23 between between IN cord-010092-uftc8inx 7316 24 SED sed NN cord-010092-uftc8inx 7316 25 treatment treatment NN cord-010092-uftc8inx 7316 26 phases phase NNS cord-010092-uftc8inx 7316 27 . . . cord-010092-uftc8inx 7317 1 The the DT cord-010092-uftc8inx 7317 2 patients patient NNS cord-010092-uftc8inx 7317 3 each each DT cord-010092-uftc8inx 7317 4 donated donate VBD cord-010092-uftc8inx 7317 5 500 500 CD cord-010092-uftc8inx 7317 6 mL ml NN cord-010092-uftc8inx 7317 7 whole whole JJ cord-010092-uftc8inx 7317 8 blood blood NN cord-010092-uftc8inx 7317 9 from from IN cord-010092-uftc8inx 7317 10 which which WDT cord-010092-uftc8inx 7317 11 the the DT cord-010092-uftc8inx 7317 12 autologous autologous JJ cord-010092-uftc8inx 7317 13 SEDs sed NNS cord-010092-uftc8inx 7317 14 were be VBD cord-010092-uftc8inx 7317 15 prepared prepare VBN cord-010092-uftc8inx 7317 16 . . . cord-010092-uftc8inx 7318 1 Allogeneic Allogeneic NNP cord-010092-uftc8inx 7318 2 SEDs sed NNS cord-010092-uftc8inx 7318 3 were be VBD cord-010092-uftc8inx 7318 4 prepared prepare VBN cord-010092-uftc8inx 7318 5 from from IN cord-010092-uftc8inx 7318 6 blood blood NN cord-010092-uftc8inx 7318 7 from from IN cord-010092-uftc8inx 7318 8 never never RB cord-010092-uftc8inx 7318 9 - - HYPH cord-010092-uftc8inx 7318 10 transfused transfuse VBN cord-010092-uftc8inx 7318 11 male male JJ cord-010092-uftc8inx 7318 12 donors donor NNS cord-010092-uftc8inx 7318 13 with with IN cord-010092-uftc8inx 7318 14 blood blood NN cord-010092-uftc8inx 7318 15 group group NN cord-010092-uftc8inx 7318 16 AB AB NNP cord-010092-uftc8inx 7318 17 . . . cord-010092-uftc8inx 7319 1 All all DT cord-010092-uftc8inx 7319 2 serum serum NN cord-010092-uftc8inx 7319 3 was be VBD cord-010092-uftc8inx 7319 4 diluted dilute VBN cord-010092-uftc8inx 7319 5 1:1 1:1 CD cord-010092-uftc8inx 7319 6 by by IN cord-010092-uftc8inx 7319 7 adding add VBG cord-010092-uftc8inx 7319 8 saline saline NN cord-010092-uftc8inx 7319 9 , , , cord-010092-uftc8inx 7319 10 and and CC cord-010092-uftc8inx 7319 11 aliquoted aliquote VBN cord-010092-uftc8inx 7319 12 in in IN cord-010092-uftc8inx 7319 13 an an DT cord-010092-uftc8inx 7319 14 eye eye NN cord-010092-uftc8inx 7319 15 drop drop NN cord-010092-uftc8inx 7319 16 dispensing dispense VBG cord-010092-uftc8inx 7319 17 system system NN cord-010092-uftc8inx 7319 18 ( ( -LRB- cord-010092-uftc8inx 7319 19 Meise Meise NNP cord-010092-uftc8inx 7319 20 , , , cord-010092-uftc8inx 7319 21 Schalksm€ Schalksm€ NNP cord-010092-uftc8inx 7319 22 uhle uhle NNP cord-010092-uftc8inx 7319 23 , , , cord-010092-uftc8inx 7319 24 Germany Germany NNP cord-010092-uftc8inx 7319 25 ) ) -RRB- cord-010092-uftc8inx 7319 26 . . . cord-010092-uftc8inx 7320 1 At at IN cord-010092-uftc8inx 7320 2 each each DT cord-010092-uftc8inx 7320 3 visit visit NN cord-010092-uftc8inx 7320 4 , , , cord-010092-uftc8inx 7320 5 the the DT cord-010092-uftc8inx 7320 6 OSDI OSDI NNP cord-010092-uftc8inx 7320 7 was be VBD cord-010092-uftc8inx 7320 8 determined determine VBN cord-010092-uftc8inx 7320 9 using use VBG cord-010092-uftc8inx 7320 10 a a DT cord-010092-uftc8inx 7320 11 validated validated JJ cord-010092-uftc8inx 7320 12 questionnaire questionnaire NN cord-010092-uftc8inx 7320 13 , , , cord-010092-uftc8inx 7320 14 with with IN cord-010092-uftc8inx 7320 15 higher high JJR cord-010092-uftc8inx 7320 16 scores score NNS cord-010092-uftc8inx 7320 17 reflecting reflect VBG cord-010092-uftc8inx 7320 18 poorer poor JJR cord-010092-uftc8inx 7320 19 outcomes outcome NNS cord-010092-uftc8inx 7320 20 . . . cord-010092-uftc8inx 7321 1 The the DT cord-010092-uftc8inx 7321 2 results result NNS cord-010092-uftc8inx 7321 3 were be VBD cord-010092-uftc8inx 7321 4 analyzed analyze VBN cord-010092-uftc8inx 7321 5 intention intention NN cord-010092-uftc8inx 7321 6 - - HYPH cord-010092-uftc8inx 7321 7 to to IN cord-010092-uftc8inx 7321 8 - - HYPH cord-010092-uftc8inx 7321 9 treat treat VB cord-010092-uftc8inx 7321 10 , , , cord-010092-uftc8inx 7321 11 and and CC cord-010092-uftc8inx 7321 12 a a DT cord-010092-uftc8inx 7321 13 random random JJ cord-010092-uftc8inx 7321 14 effects effect NNS cord-010092-uftc8inx 7321 15 linear linear JJ cord-010092-uftc8inx 7321 16 mixed mixed JJ cord-010092-uftc8inx 7321 17 model model NN cord-010092-uftc8inx 7321 18 for for IN cord-010092-uftc8inx 7321 19 cross cross JJ cord-010092-uftc8inx 7321 20 - - HYPH cord-010092-uftc8inx 7321 21 over over RP cord-010092-uftc8inx 7321 22 design design NN cord-010092-uftc8inx 7321 23 was be VBD cord-010092-uftc8inx 7321 24 used use VBN cord-010092-uftc8inx 7321 25 . . . cord-010092-uftc8inx 7322 1 Results result NNS cord-010092-uftc8inx 7322 2 : : : cord-010092-uftc8inx 7323 1 In in IN cord-010092-uftc8inx 7323 2 total total JJ cord-010092-uftc8inx 7323 3 , , , cord-010092-uftc8inx 7323 4 19 19 CD cord-010092-uftc8inx 7323 5 patients patient NNS cord-010092-uftc8inx 7323 6 were be VBD cord-010092-uftc8inx 7323 7 enrolled enrol VBN cord-010092-uftc8inx 7323 8 , , , cord-010092-uftc8inx 7323 9 4 4 CD cord-010092-uftc8inx 7323 10 of of IN cord-010092-uftc8inx 7323 11 whom whom WP cord-010092-uftc8inx 7323 12 were be VBD cord-010092-uftc8inx 7323 13 excluded exclude VBN cord-010092-uftc8inx 7323 14 because because IN cord-010092-uftc8inx 7323 15 they -PRON- PRP cord-010092-uftc8inx 7323 16 failed fail VBD cord-010092-uftc8inx 7323 17 the the DT cord-010092-uftc8inx 7323 18 autologous autologous JJ cord-010092-uftc8inx 7323 19 blood blood NN cord-010092-uftc8inx 7323 20 donation donation NN cord-010092-uftc8inx 7323 21 . . . cord-010092-uftc8inx 7324 1 Background background NN cord-010092-uftc8inx 7324 2 : : : cord-010092-uftc8inx 7325 1 The the DT cord-010092-uftc8inx 7325 2 following follow VBG cord-010092-uftc8inx 7325 3 blood blood NN cord-010092-uftc8inx 7325 4 components component NNS cord-010092-uftc8inx 7325 5 for for IN cord-010092-uftc8inx 7325 6 non non JJ cord-010092-uftc8inx 7325 7 - - JJ cord-010092-uftc8inx 7325 8 transfusional transfusional JJ cord-010092-uftc8inx 7325 9 use use NN cord-010092-uftc8inx 7325 10 ( ( -LRB- cord-010092-uftc8inx 7325 11 BCNTU BCNTU NNP cord-010092-uftc8inx 7325 12 ) ) -RRB- cord-010092-uftc8inx 7325 13 are be VBP cord-010092-uftc8inx 7325 14 produced produce VBN cord-010092-uftc8inx 7325 15 in in IN cord-010092-uftc8inx 7325 16 our -PRON- PRP$ cord-010092-uftc8inx 7325 17 Transfusional Transfusional NNP cord-010092-uftc8inx 7325 18 Center Center NNP cord-010092-uftc8inx 7325 19 ( ( -LRB- cord-010092-uftc8inx 7325 20 TC TC NNP cord-010092-uftc8inx 7325 21 ) ) -RRB- cord-010092-uftc8inx 7325 22 : : : cord-010092-uftc8inx 7326 1 1 1 LS cord-010092-uftc8inx 7326 2 ) ) -RRB- cord-010092-uftc8inx 7326 3 allogeneic allogeneic IN cord-010092-uftc8inx 7326 4 platelet platelet NN cord-010092-uftc8inx 7326 5 gel gel NN cord-010092-uftc8inx 7326 6 ( ( -LRB- cord-010092-uftc8inx 7326 7 PG PG NNP cord-010092-uftc8inx 7326 8 ) ) -RRB- cord-010092-uftc8inx 7326 9 , , , cord-010092-uftc8inx 7326 10 derived derive VBN cord-010092-uftc8inx 7326 11 from from IN cord-010092-uftc8inx 7326 12 Buffy Buffy NNP cord-010092-uftc8inx 7326 13 - - HYPH cord-010092-uftc8inx 7326 14 Coats Coats NNP cord-010092-uftc8inx 7326 15 ( ( -LRB- cord-010092-uftc8inx 7326 16 BC BC NNP cord-010092-uftc8inx 7326 17 ) ) -RRB- cord-010092-uftc8inx 7326 18 and and CC cord-010092-uftc8inx 7326 19 human human JJ cord-010092-uftc8inx 7326 20 cord cord NN cord-010092-uftc8inx 7326 21 blood blood NN cord-010092-uftc8inx 7326 22 platelet platelet NN cord-010092-uftc8inx 7326 23 gel gel NN cord-010092-uftc8inx 7326 24 ( ( -LRB- cord-010092-uftc8inx 7326 25 CBPG CBPG NNP cord-010092-uftc8inx 7326 26 ) ) -RRB- cord-010092-uftc8inx 7326 27 ; ; : cord-010092-uftc8inx 7326 28 2 2 LS cord-010092-uftc8inx 7326 29 ) ) -RRB- cord-010092-uftc8inx 7326 30 Autologous Autologous NNP cord-010092-uftc8inx 7326 31 Serum Serum NNP cord-010092-uftc8inx 7326 32 Eye Eye NNP cord-010092-uftc8inx 7326 33 Drops drop VBZ cord-010092-uftc8inx 7326 34 ( ( -LRB- cord-010092-uftc8inx 7326 35 SED SED NNP cord-010092-uftc8inx 7326 36 ) ) -RRB- cord-010092-uftc8inx 7326 37 . . . cord-010092-uftc8inx 7327 1 The the DT cord-010092-uftc8inx 7327 2 creation creation NN cord-010092-uftc8inx 7327 3 of of IN cord-010092-uftc8inx 7327 4 both both DT cord-010092-uftc8inx 7327 5 types type NNS cord-010092-uftc8inx 7327 6 of of IN cord-010092-uftc8inx 7327 7 platelet platelet NN cord-010092-uftc8inx 7327 8 gel gel NN cord-010092-uftc8inx 7327 9 started start VBD cord-010092-uftc8inx 7327 10 in in IN cord-010092-uftc8inx 7327 11 2014 2014 CD cord-010092-uftc8inx 7327 12 but but CC cord-010092-uftc8inx 7327 13 only only RB cord-010092-uftc8inx 7327 14 in in IN cord-010092-uftc8inx 7327 15 2017 2017 CD cord-010092-uftc8inx 7327 16 we -PRON- PRP cord-010092-uftc8inx 7327 17 confirmed confirm VBD cord-010092-uftc8inx 7327 18 the the DT cord-010092-uftc8inx 7327 19 process process NN cord-010092-uftc8inx 7327 20 for for IN cord-010092-uftc8inx 7327 21 daily daily JJ cord-010092-uftc8inx 7327 22 production production NN cord-010092-uftc8inx 7327 23 : : : cord-010092-uftc8inx 7327 24 these these DT cord-010092-uftc8inx 7327 25 blood blood NN cord-010092-uftc8inx 7327 26 components component NNS cord-010092-uftc8inx 7327 27 are be VBP cord-010092-uftc8inx 7327 28 used use VBN cord-010092-uftc8inx 7327 29 to to TO cord-010092-uftc8inx 7327 30 treat treat VB cord-010092-uftc8inx 7327 31 pediatric pediatric JJ cord-010092-uftc8inx 7327 32 patients patient NNS cord-010092-uftc8inx 7327 33 with with IN cord-010092-uftc8inx 7327 34 Epidermolysis Epidermolysis NNP cord-010092-uftc8inx 7327 35 Bullosa Bullosa NNP cord-010092-uftc8inx 7327 36 . . . cord-010092-uftc8inx 7328 1 The the DT cord-010092-uftc8inx 7328 2 SED sed NN cord-010092-uftc8inx 7328 3 , , , cord-010092-uftc8inx 7328 4 produced produce VBN cord-010092-uftc8inx 7328 5 from from IN cord-010092-uftc8inx 7328 6 2018 2018 CD cord-010092-uftc8inx 7328 7 , , , cord-010092-uftc8inx 7328 8 is be VBZ cord-010092-uftc8inx 7328 9 dedicated dedicate VBN cord-010092-uftc8inx 7328 10 to to TO cord-010092-uftc8inx 7328 11 treat treat VB cord-010092-uftc8inx 7328 12 patients patient NNS cord-010092-uftc8inx 7328 13 with with IN cord-010092-uftc8inx 7328 14 Dry Dry NNP cord-010092-uftc8inx 7328 15 Eye Eye NNP cord-010092-uftc8inx 7328 16 Syndrome Syndrome NNP cord-010092-uftc8inx 7328 17 . . . cord-010092-uftc8inx 7329 1 Aims aim VBZ cord-010092-uftc8inx 7329 2 : : : cord-010092-uftc8inx 7329 3 Production production NN cord-010092-uftc8inx 7329 4 and and CC cord-010092-uftc8inx 7329 5 storage storage NN cord-010092-uftc8inx 7329 6 BCNTU BCNTU NNP cord-010092-uftc8inx 7329 7 . . . cord-010092-uftc8inx 7330 1 Methods method NNS cord-010092-uftc8inx 7330 2 : : : cord-010092-uftc8inx 7331 1 The the DT cord-010092-uftc8inx 7331 2 whole whole JJ cord-010092-uftc8inx 7331 3 process process NN cord-010092-uftc8inx 7331 4 production production NN cord-010092-uftc8inx 7331 5 of of IN cord-010092-uftc8inx 7331 6 BCNTU BCNTU NNP cord-010092-uftc8inx 7331 7 is be VBZ cord-010092-uftc8inx 7331 8 traced trace VBN cord-010092-uftc8inx 7331 9 on on IN cord-010092-uftc8inx 7331 10 the the DT cord-010092-uftc8inx 7331 11 Transfusional Transfusional NNP cord-010092-uftc8inx 7331 12 informatic informatic JJ cord-010092-uftc8inx 7331 13 system system NN cord-010092-uftc8inx 7331 14 ( ( -LRB- cord-010092-uftc8inx 7331 15 Emonet Emonet NNP cord-010092-uftc8inx 7331 16 - - HYPH cord-010092-uftc8inx 7331 17 Insielmercato Insielmercato NNP cord-010092-uftc8inx 7331 18 ) ) -RRB- cord-010092-uftc8inx 7331 19 , , , cord-010092-uftc8inx 7331 20 under under IN cord-010092-uftc8inx 7331 21 the the DT cord-010092-uftc8inx 7331 22 same same JJ cord-010092-uftc8inx 7331 23 conditions condition NNS cord-010092-uftc8inx 7331 24 of of IN cord-010092-uftc8inx 7331 25 another another DT cord-010092-uftc8inx 7331 26 blood blood NN cord-010092-uftc8inx 7331 27 transfusional transfusional JJ cord-010092-uftc8inx 7331 28 components component NNS cord-010092-uftc8inx 7331 29 . . . cord-010092-uftc8inx 7332 1 The the DT cord-010092-uftc8inx 7332 2 process process NN cord-010092-uftc8inx 7332 3 takes take VBZ cord-010092-uftc8inx 7332 4 place place NN cord-010092-uftc8inx 7332 5 in in IN cord-010092-uftc8inx 7332 6 closed closed JJ cord-010092-uftc8inx 7332 7 circuit circuit NN cord-010092-uftc8inx 7332 8 using use VBG cord-010092-uftc8inx 7332 9 the the DT cord-010092-uftc8inx 7332 10 laminar laminar JJ cord-010092-uftc8inx 7332 11 flow flow NN cord-010092-uftc8inx 7332 12 hood hood NN cord-010092-uftc8inx 7332 13 . . . cord-010092-uftc8inx 7333 1 1 1 LS cord-010092-uftc8inx 7333 2 ) ) -RRB- cord-010092-uftc8inx 7334 1 PG pg NN cord-010092-uftc8inx 7334 2 production production NN cord-010092-uftc8inx 7334 3 starts start VBZ cord-010092-uftc8inx 7334 4 from from IN cord-010092-uftc8inx 7334 5 the the DT cord-010092-uftc8inx 7334 6 BC BC NNP cord-010092-uftc8inx 7334 7 resuspended resuspend VBD cord-010092-uftc8inx 7334 8 in in IN cord-010092-uftc8inx 7334 9 plasma plasma NN cord-010092-uftc8inx 7334 10 that that WDT cord-010092-uftc8inx 7334 11 are be VBP cord-010092-uftc8inx 7334 12 not not RB cord-010092-uftc8inx 7334 13 used use VBN cord-010092-uftc8inx 7334 14 for for IN cord-010092-uftc8inx 7334 15 daily daily JJ cord-010092-uftc8inx 7334 16 platelet platelet NN cord-010092-uftc8inx 7335 1 concentrates concentrate NNS cord-010092-uftc8inx 7335 2 , , , cord-010092-uftc8inx 7335 3 instead instead RB cord-010092-uftc8inx 7335 4 the the DT cord-010092-uftc8inx 7335 5 CBPG CBPG NNP cord-010092-uftc8inx 7335 6 is be VBZ cord-010092-uftc8inx 7335 7 produced produce VBN cord-010092-uftc8inx 7335 8 using use VBG cord-010092-uftc8inx 7335 9 cord cord NN cord-010092-uftc8inx 7335 10 blood blood NN cord-010092-uftc8inx 7335 11 units unit NNS cord-010092-uftc8inx 7335 12 that that WDT cord-010092-uftc8inx 7335 13 are be VBP cord-010092-uftc8inx 7335 14 not not RB cord-010092-uftc8inx 7335 15 used use VBN cord-010092-uftc8inx 7335 16 for for IN cord-010092-uftc8inx 7335 17 hematopoietic hematopoietic JJ cord-010092-uftc8inx 7335 18 transplant transplant NN cord-010092-uftc8inx 7335 19 . . . cord-010092-uftc8inx 7336 1 Both both DT cord-010092-uftc8inx 7336 2 have have VBP cord-010092-uftc8inx 7336 3 a a DT cord-010092-uftc8inx 7336 4 platelet platelet NN cord-010092-uftc8inx 7336 5 concentration concentration NN cord-010092-uftc8inx 7336 6 between between IN cord-010092-uftc8inx 7336 7 800 800 CD cord-010092-uftc8inx 7336 8 - - CD cord-010092-uftc8inx 7336 9 1200 1200 CD cord-010092-uftc8inx 7336 10 10 10 CD cord-010092-uftc8inx 7336 11 3 3 CD cord-010092-uftc8inx 7336 12 /lL /lL . cord-010092-uftc8inx 7336 13 and and CC cord-010092-uftc8inx 7336 14 negative negative JJ cord-010092-uftc8inx 7336 15 blood blood NN cord-010092-uftc8inx 7336 16 cultures culture NNS cord-010092-uftc8inx 7336 17 , , , cord-010092-uftc8inx 7336 18 required require VBN cord-010092-uftc8inx 7336 19 by by IN cord-010092-uftc8inx 7336 20 the the DT cord-010092-uftc8inx 7336 21 Italian italian JJ cord-010092-uftc8inx 7336 22 law law NN cord-010092-uftc8inx 7336 23 ; ; : cord-010092-uftc8inx 7336 24 the the DT cord-010092-uftc8inx 7336 25 units unit NNS cord-010092-uftc8inx 7336 26 are be VBP cord-010092-uftc8inx 7336 27 frozen freeze VBN cord-010092-uftc8inx 7336 28 at at IN cord-010092-uftc8inx 7336 29 À80 À80 NNP cord-010092-uftc8inx 7336 30 ° ° NN cord-010092-uftc8inx 7336 31 C c NN cord-010092-uftc8inx 7336 32 and and CC cord-010092-uftc8inx 7336 33 last last JJ cord-010092-uftc8inx 7336 34 5-year 5-year CD cord-010092-uftc8inx 7336 35 . . . cord-010092-uftc8inx 7337 1 PG PG NNP cord-010092-uftc8inx 7337 2 and and CC cord-010092-uftc8inx 7337 3 CBPG CBPG NNP cord-010092-uftc8inx 7337 4 must must MD cord-010092-uftc8inx 7337 5 be be VB cord-010092-uftc8inx 7337 6 activated activate VBN cord-010092-uftc8inx 7337 7 with with IN cord-010092-uftc8inx 7337 8 calcium calcium NN cord-010092-uftc8inx 7337 9 gluconate gluconate NN cord-010092-uftc8inx 7337 10 or or CC cord-010092-uftc8inx 7337 11 batroxobin batroxobin NNP cord-010092-uftc8inx 7337 12 to to TO cord-010092-uftc8inx 7337 13 be be VB cord-010092-uftc8inx 7337 14 used use VBN cord-010092-uftc8inx 7337 15 . . . cord-010092-uftc8inx 7338 1 2 2 LS cord-010092-uftc8inx 7338 2 ) ) -RRB- cord-010092-uftc8inx 7339 1 The the DT cord-010092-uftc8inx 7339 2 ophthalmologist ophthalmologist NN cord-010092-uftc8inx 7339 3 's 's POS cord-010092-uftc8inx 7339 4 patients patient NNS cord-010092-uftc8inx 7339 5 , , , cord-010092-uftc8inx 7339 6 with with IN cord-010092-uftc8inx 7339 7 Dry Dry NNP cord-010092-uftc8inx 7339 8 Eye Eye NNP cord-010092-uftc8inx 7339 9 Syndrome Syndrome NNP cord-010092-uftc8inx 7339 10 , , , cord-010092-uftc8inx 7339 11 donate donate VB cord-010092-uftc8inx 7339 12 120 120 CD cord-010092-uftc8inx 7339 13 mL mL NNS cord-010092-uftc8inx 7339 14 of of IN cord-010092-uftc8inx 7339 15 autologous autologous JJ cord-010092-uftc8inx 7339 16 blood blood NN cord-010092-uftc8inx 7339 17 ; ; : cord-010092-uftc8inx 7339 18 the the DT cord-010092-uftc8inx 7339 19 serum serum NN cord-010092-uftc8inx 7339 20 is be VBZ cord-010092-uftc8inx 7339 21 separated separate VBN cord-010092-uftc8inx 7339 22 and and CC cord-010092-uftc8inx 7339 23 after after IN cord-010092-uftc8inx 7339 24 the the DT cord-010092-uftc8inx 7339 25 dilution dilution NN cord-010092-uftc8inx 7339 26 with with IN cord-010092-uftc8inx 7339 27 a a DT cord-010092-uftc8inx 7339 28 balanced balanced JJ cord-010092-uftc8inx 7339 29 saline saline NN cord-010092-uftc8inx 7339 30 solution solution NN cord-010092-uftc8inx 7339 31 ( ( -LRB- cord-010092-uftc8inx 7339 32 30 30 CD cord-010092-uftc8inx 7339 33 % % NN cord-010092-uftc8inx 7339 34 ) ) -RRB- cord-010092-uftc8inx 7339 35 are be VBP cord-010092-uftc8inx 7339 36 divided divide VBN cord-010092-uftc8inx 7339 37 in in IN cord-010092-uftc8inx 7339 38 2 2 CD cord-010092-uftc8inx 7339 39 boxes box NNS cord-010092-uftc8inx 7339 40 containing contain VBG cord-010092-uftc8inx 7339 41 30 30 CD cord-010092-uftc8inx 7339 42 single single JJ cord-010092-uftc8inx 7339 43 - - HYPH cord-010092-uftc8inx 7339 44 dose dose NN cord-010092-uftc8inx 7339 45 vials vial NNS cord-010092-uftc8inx 7339 46 each each DT cord-010092-uftc8inx 7339 47 : : : cord-010092-uftc8inx 7340 1 they -PRON- PRP cord-010092-uftc8inx 7340 2 are be VBP cord-010092-uftc8inx 7340 3 stored store VBN cord-010092-uftc8inx 7340 4 at at IN cord-010092-uftc8inx 7340 5 À80 À80 NNP cord-010092-uftc8inx 7340 6 ° ° NN cord-010092-uftc8inx 7340 7 C c NN cord-010092-uftc8inx 7341 1 and and CC cord-010092-uftc8inx 7341 2 they -PRON- PRP cord-010092-uftc8inx 7341 3 last last VBP cord-010092-uftc8inx 7341 4 one one CD cord-010092-uftc8inx 7341 5 year year NN cord-010092-uftc8inx 7341 6 . . . cord-010092-uftc8inx 7342 1 Negative negative JJ cord-010092-uftc8inx 7342 2 blood blood NN cord-010092-uftc8inx 7342 3 culture culture NN cord-010092-uftc8inx 7342 4 was be VBD cord-010092-uftc8inx 7342 5 evaluated evaluate VBN cord-010092-uftc8inx 7342 6 . . . cord-010092-uftc8inx 7343 1 Results result NNS cord-010092-uftc8inx 7343 2 : : : cord-010092-uftc8inx 7344 1 Background background NN cord-010092-uftc8inx 7344 2 : : : cord-010092-uftc8inx 7344 3 Candida Candida NNP cord-010092-uftc8inx 7344 4 albicans albican NNS cord-010092-uftc8inx 7344 5 is be VBZ cord-010092-uftc8inx 7344 6 the the DT cord-010092-uftc8inx 7344 7 most most RBS cord-010092-uftc8inx 7344 8 common common JJ cord-010092-uftc8inx 7344 9 pathogen pathogen NN cord-010092-uftc8inx 7344 10 detected detect VBN cord-010092-uftc8inx 7344 11 in in IN cord-010092-uftc8inx 7344 12 fungal fungal JJ cord-010092-uftc8inx 7344 13 infections infection NNS cord-010092-uftc8inx 7344 14 . . . cord-010092-uftc8inx 7345 1 Aims aim VBZ cord-010092-uftc8inx 7345 2 : : : cord-010092-uftc8inx 7346 1 In in IN cord-010092-uftc8inx 7346 2 this this DT cord-010092-uftc8inx 7346 3 study study NN cord-010092-uftc8inx 7346 4 , , , cord-010092-uftc8inx 7346 5 we -PRON- PRP cord-010092-uftc8inx 7346 6 aimed aim VBD cord-010092-uftc8inx 7346 7 to to TO cord-010092-uftc8inx 7346 8 evaluate evaluate VB cord-010092-uftc8inx 7346 9 the the DT cord-010092-uftc8inx 7346 10 in in FW cord-010092-uftc8inx 7346 11 vitro vitro FW cord-010092-uftc8inx 7346 12 antifungal antifungal JJ cord-010092-uftc8inx 7346 13 activity activity NN cord-010092-uftc8inx 7346 14 of of IN cord-010092-uftc8inx 7346 15 volunteerderived volunteerderived JJ cord-010092-uftc8inx 7346 16 platelet platelet NN cord-010092-uftc8inx 7346 17 rich rich JJ cord-010092-uftc8inx 7346 18 plasma plasma NN cord-010092-uftc8inx 7346 19 ( ( -LRB- cord-010092-uftc8inx 7346 20 PRP PRP NNP cord-010092-uftc8inx 7346 21 ) ) -RRB- cord-010092-uftc8inx 7346 22 against against IN cord-010092-uftc8inx 7346 23 C. C. NNP cord-010092-uftc8inx 7346 24 albicans albican NNS cord-010092-uftc8inx 7346 25 ATCC ATCC NNP cord-010092-uftc8inx 7346 26 10231 10231 CD cord-010092-uftc8inx 7346 27 strain strain NN cord-010092-uftc8inx 7346 28 and and CC cord-010092-uftc8inx 7346 29 the the DT cord-010092-uftc8inx 7346 30 possible possible JJ cord-010092-uftc8inx 7346 31 effects effect NNS cord-010092-uftc8inx 7346 32 of of IN cord-010092-uftc8inx 7346 33 certain certain JJ cord-010092-uftc8inx 7346 34 chemokines chemokine NNS cord-010092-uftc8inx 7346 35 , , , cord-010092-uftc8inx 7346 36 kinocidins kinocidin NNS cord-010092-uftc8inx 7346 37 that that WDT cord-010092-uftc8inx 7346 38 might may MD cord-010092-uftc8inx 7346 39 play play VB cord-010092-uftc8inx 7346 40 a a DT cord-010092-uftc8inx 7346 41 role role NN cord-010092-uftc8inx 7346 42 in in IN cord-010092-uftc8inx 7346 43 this this DT cord-010092-uftc8inx 7346 44 activity activity NN cord-010092-uftc8inx 7346 45 . . . cord-010092-uftc8inx 7347 1 Methods method NNS cord-010092-uftc8inx 7347 2 : : : cord-010092-uftc8inx 7347 3 PRP prp NN cord-010092-uftc8inx 7347 4 from from IN cord-010092-uftc8inx 7347 5 nine nine CD cord-010092-uftc8inx 7347 6 volunteers volunteer NNS cord-010092-uftc8inx 7347 7 were be VBD cord-010092-uftc8inx 7347 8 derived derive VBN cord-010092-uftc8inx 7347 9 by by IN cord-010092-uftc8inx 7347 10 using use VBG cord-010092-uftc8inx 7347 11 Magellan Magellan NNP cord-010092-uftc8inx 7347 12 PRP PRP NNP cord-010092-uftc8inx 7347 13 â â NNP cord-010092-uftc8inx 7347 14 kit kit NN cord-010092-uftc8inx 7347 15 . . . cord-010092-uftc8inx 7348 1 10 10 CD cord-010092-uftc8inx 7348 2 % % NN cord-010092-uftc8inx 7348 3 calcium calcium NN cord-010092-uftc8inx 7348 4 gluconate gluconate NNP cord-010092-uftc8inx 7348 5 was be VBD cord-010092-uftc8inx 7348 6 used use VBN cord-010092-uftc8inx 7348 7 to to TO cord-010092-uftc8inx 7348 8 obtain obtain VB cord-010092-uftc8inx 7348 9 autologous autologous JJ cord-010092-uftc8inx 7348 10 thrombin thrombin NN cord-010092-uftc8inx 7348 11 . . . cord-010092-uftc8inx 7349 1 C. C. NNP cord-010092-uftc8inx 7349 2 albicans albican NNS cord-010092-uftc8inx 7349 3 isolates isolate VBZ cord-010092-uftc8inx 7349 4 with with IN cord-010092-uftc8inx 7349 5 a a DT cord-010092-uftc8inx 7349 6 final final JJ cord-010092-uftc8inx 7349 7 yeast yeast NN cord-010092-uftc8inx 7349 8 concentration concentration NN cord-010092-uftc8inx 7349 9 of of IN cord-010092-uftc8inx 7349 10 1 1 CD cord-010092-uftc8inx 7349 11 9 9 CD cord-010092-uftc8inx 7349 12 10 10 CD cord-010092-uftc8inx 7349 13 3 3 CD cord-010092-uftc8inx 7349 14 cfu cfu NN cord-010092-uftc8inx 7349 15 / / SYM cord-010092-uftc8inx 7349 16 ml ml NN cord-010092-uftc8inx 7349 17 and and CC cord-010092-uftc8inx 7349 18 1 1 CD cord-010092-uftc8inx 7349 19 9 9 CD cord-010092-uftc8inx 7349 20 10 10 CD cord-010092-uftc8inx 7349 21 4 4 CD cord-010092-uftc8inx 7349 22 cfu cfu NNP cord-010092-uftc8inx 7349 23 / / SYM cord-010092-uftc8inx 7349 24 ml ml NNS cord-010092-uftc8inx 7349 25 were be VBD cord-010092-uftc8inx 7349 26 inoculated inoculate VBN cord-010092-uftc8inx 7349 27 on on IN cord-010092-uftc8inx 7349 28 Sabouraud Sabouraud NNP cord-010092-uftc8inx 7349 29 Dextrose Dextrose NNP cord-010092-uftc8inx 7349 30 Agar Agar NNP cord-010092-uftc8inx 7349 31 at at IN cord-010092-uftc8inx 7349 32 the the DT cord-010092-uftc8inx 7349 33 1 1 CD cord-010092-uftc8inx 7349 34 st st NNP cord-010092-uftc8inx 7349 35 , , , cord-010092-uftc8inx 7349 36 2 2 CD cord-010092-uftc8inx 7349 37 nd nd NNP cord-010092-uftc8inx 7349 38 , , , cord-010092-uftc8inx 7349 39 4 4 CD cord-010092-uftc8inx 7349 40 th th XX cord-010092-uftc8inx 7349 41 , , , cord-010092-uftc8inx 7349 42 8 8 CD cord-010092-uftc8inx 7349 43 th th XX cord-010092-uftc8inx 7349 44 and and CC cord-010092-uftc8inx 7350 1 16 16 CD cord-010092-uftc8inx 7350 2 th th XX cord-010092-uftc8inx 7350 3 hours hour NNS cord-010092-uftc8inx 7350 4 of of IN cord-010092-uftc8inx 7350 5 incubation incubation NN cord-010092-uftc8inx 7350 6 to to TO cord-010092-uftc8inx 7350 7 reveal reveal VB cord-010092-uftc8inx 7350 8 the the DT cord-010092-uftc8inx 7350 9 antifungal antifungal JJ cord-010092-uftc8inx 7350 10 activity activity NN cord-010092-uftc8inx 7350 11 of of IN cord-010092-uftc8inx 7350 12 autologous autologous JJ cord-010092-uftc8inx 7350 13 thrombin thrombin NN cord-010092-uftc8inx 7350 14 - - HYPH cord-010092-uftc8inx 7350 15 activated activate VBN cord-010092-uftc8inx 7350 16 PRP prp NN cord-010092-uftc8inx 7350 17 . . . cord-010092-uftc8inx 7351 1 The the DT cord-010092-uftc8inx 7351 2 colonies colony NNS cord-010092-uftc8inx 7351 3 were be VBD cord-010092-uftc8inx 7351 4 counted count VBN cord-010092-uftc8inx 7351 5 after after IN cord-010092-uftc8inx 7351 6 18 18 CD cord-010092-uftc8inx 7351 7 - - SYM cord-010092-uftc8inx 7351 8 24 24 CD cord-010092-uftc8inx 7351 9 h h NN cord-010092-uftc8inx 7351 10 of of IN cord-010092-uftc8inx 7351 11 incubation incubation NN cord-010092-uftc8inx 7351 12 at at IN cord-010092-uftc8inx 7351 13 30 30 CD cord-010092-uftc8inx 7351 14 ° ° NN cord-010092-uftc8inx 7351 15 C c NN cord-010092-uftc8inx 7351 16 . . . cord-010092-uftc8inx 7352 1 Chemokines Chemokines NNPS cord-010092-uftc8inx 7352 2 and and CC cord-010092-uftc8inx 7352 3 kinocidins kinocidin NNS cord-010092-uftc8inx 7352 4 ( ( -LRB- cord-010092-uftc8inx 7352 5 Platelet platelet NN cord-010092-uftc8inx 7352 6 Factor-4 Factor-4 NNP cord-010092-uftc8inx 7352 7 , , , cord-010092-uftc8inx 7353 1 Interleukin-8 Interleukin-8 NNP cord-010092-uftc8inx 7353 2 and and CC cord-010092-uftc8inx 7353 3 Thymosin Thymosin NNP cord-010092-uftc8inx 7353 4 - - HYPH cord-010092-uftc8inx 7353 5 b4 b4 NNP cord-010092-uftc8inx 7353 6 ) ) -RRB- cord-010092-uftc8inx 7353 7 were be VBD cord-010092-uftc8inx 7353 8 also also RB cord-010092-uftc8inx 7353 9 measured measure VBN cord-010092-uftc8inx 7353 10 simultaneously simultaneously RB cord-010092-uftc8inx 7353 11 by by IN cord-010092-uftc8inx 7353 12 ELISA ELISA NNP cord-010092-uftc8inx 7353 13 method method NN cord-010092-uftc8inx 7353 14 . . . cord-010092-uftc8inx 7354 1 Results result NNS cord-010092-uftc8inx 7354 2 : : : cord-010092-uftc8inx 7355 1 Compared compare VBN cord-010092-uftc8inx 7355 2 with with IN cord-010092-uftc8inx 7355 3 the the DT cord-010092-uftc8inx 7355 4 PBS PBS NNP cord-010092-uftc8inx 7355 5 - - HYPH cord-010092-uftc8inx 7355 6 control control NN cord-010092-uftc8inx 7355 7 group group NN cord-010092-uftc8inx 7355 8 , , , cord-010092-uftc8inx 7355 9 the the DT cord-010092-uftc8inx 7355 10 PRP-10 PRP-10 NNP cord-010092-uftc8inx 7355 11 3 3 CD cord-010092-uftc8inx 7355 12 group group NN cord-010092-uftc8inx 7355 13 showed show VBD cord-010092-uftc8inx 7355 14 that that IN cord-010092-uftc8inx 7355 15 the the DT cord-010092-uftc8inx 7355 16 antifungal antifungal JJ cord-010092-uftc8inx 7355 17 activity activity NN cord-010092-uftc8inx 7355 18 was be VBD cord-010092-uftc8inx 7355 19 still still RB cord-010092-uftc8inx 7355 20 going go VBG cord-010092-uftc8inx 7355 21 on on RP cord-010092-uftc8inx 7355 22 at at IN cord-010092-uftc8inx 7355 23 the the DT cord-010092-uftc8inx 7355 24 8 8 CD cord-010092-uftc8inx 7355 25 th th CD cord-010092-uftc8inx 7355 26 hour hour NN cord-010092-uftc8inx 7355 27 . . . cord-010092-uftc8inx 7356 1 The the DT cord-010092-uftc8inx 7356 2 difference difference NN cord-010092-uftc8inx 7356 3 in in IN cord-010092-uftc8inx 7356 4 colony colony NN cord-010092-uftc8inx 7356 5 production production NN cord-010092-uftc8inx 7356 6 between between IN cord-010092-uftc8inx 7356 7 the the DT cord-010092-uftc8inx 7356 8 two two CD cord-010092-uftc8inx 7356 9 groups group NNS cord-010092-uftc8inx 7356 10 at at IN cord-010092-uftc8inx 7356 11 8 8 CD cord-010092-uftc8inx 7356 12 th th CD cord-010092-uftc8inx 7356 13 hour hour NN cord-010092-uftc8inx 7356 14 was be VBD cord-010092-uftc8inx 7356 15 statistically statistically RB cord-010092-uftc8inx 7356 16 significant significant JJ cord-010092-uftc8inx 7356 17 ( ( -LRB- cord-010092-uftc8inx 7356 18 P p NN cord-010092-uftc8inx 7356 19 < < XX cord-010092-uftc8inx 7356 20 0.05 0.05 CD cord-010092-uftc8inx 7356 21 ) ) -RRB- cord-010092-uftc8inx 7356 22 . . . cord-010092-uftc8inx 7357 1 It -PRON- PRP cord-010092-uftc8inx 7357 2 was be VBD cord-010092-uftc8inx 7357 3 observed observe VBN cord-010092-uftc8inx 7357 4 that that IN cord-010092-uftc8inx 7357 5 the the DT cord-010092-uftc8inx 7357 6 antifungal antifungal JJ cord-010092-uftc8inx 7357 7 activity activity NN cord-010092-uftc8inx 7357 8 continued continue VBD cord-010092-uftc8inx 7357 9 at at IN cord-010092-uftc8inx 7357 10 the the DT cord-010092-uftc8inx 7357 11 4 4 CD cord-010092-uftc8inx 7357 12 th th CD cord-010092-uftc8inx 7357 13 hour hour NN cord-010092-uftc8inx 7357 14 , , , cord-010092-uftc8inx 7357 15 decreased decrease VBD cord-010092-uftc8inx 7357 16 at at IN cord-010092-uftc8inx 7357 17 the the DT cord-010092-uftc8inx 7357 18 8 8 CD cord-010092-uftc8inx 7357 19 th th CD cord-010092-uftc8inx 7357 20 hour hour NN cord-010092-uftc8inx 7357 21 in in IN cord-010092-uftc8inx 7357 22 the the DT cord-010092-uftc8inx 7357 23 group group NN cord-010092-uftc8inx 7357 24 PRP-10 PRP-10 NNP cord-010092-uftc8inx 7357 25 4 4 CD cord-010092-uftc8inx 7357 26 group group NN cord-010092-uftc8inx 7357 27 . . . cord-010092-uftc8inx 7358 1 Although although IN cord-010092-uftc8inx 7358 2 the the DT cord-010092-uftc8inx 7358 3 same same JJ cord-010092-uftc8inx 7358 4 amount amount NN cord-010092-uftc8inx 7358 5 of of IN cord-010092-uftc8inx 7358 6 PRP PRP NNP cord-010092-uftc8inx 7358 7 was be VBD cord-010092-uftc8inx 7358 8 used use VBN cord-010092-uftc8inx 7358 9 and and CC cord-010092-uftc8inx 7358 10 the the DT cord-010092-uftc8inx 7358 11 same same JJ cord-010092-uftc8inx 7358 12 amount amount NN cord-010092-uftc8inx 7358 13 of of IN cord-010092-uftc8inx 7358 14 chemokine chemokine NN cord-010092-uftc8inx 7358 15 and and CC cord-010092-uftc8inx 7358 16 kinocidins kinocidin NNS cord-010092-uftc8inx 7358 17 were be VBD cord-010092-uftc8inx 7358 18 released release VBN cord-010092-uftc8inx 7358 19 in in IN cord-010092-uftc8inx 7358 20 both both DT cord-010092-uftc8inx 7358 21 groups group NNS cord-010092-uftc8inx 7358 22 , , , cord-010092-uftc8inx 7358 23 the the DT cord-010092-uftc8inx 7358 24 concentration concentration NN cord-010092-uftc8inx 7358 25 of of IN cord-010092-uftc8inx 7358 26 C. C. NNP cord-010092-uftc8inx 7358 27 albicans albican NNS cord-010092-uftc8inx 7358 28 was be VBD cord-010092-uftc8inx 7358 29 considered consider VBN cord-010092-uftc8inx 7358 30 to to TO cord-010092-uftc8inx 7358 31 be be VB cord-010092-uftc8inx 7358 32 important important JJ cord-010092-uftc8inx 7358 33 in in IN cord-010092-uftc8inx 7358 34 the the DT cord-010092-uftc8inx 7358 35 detection detection NN cord-010092-uftc8inx 7358 36 of of IN cord-010092-uftc8inx 7358 37 more more JJR cord-010092-uftc8inx 7358 38 effective effective JJ cord-010092-uftc8inx 7358 39 PRP-10 PRP-10 NNP cord-010092-uftc8inx 7358 40 3 3 CD cord-010092-uftc8inx 7358 41 group group NN cord-010092-uftc8inx 7358 42 . . . cord-010092-uftc8inx 7359 1 Although although IN cord-010092-uftc8inx 7359 2 there there EX cord-010092-uftc8inx 7359 3 was be VBD cord-010092-uftc8inx 7359 4 an an DT cord-010092-uftc8inx 7359 5 increase increase NN cord-010092-uftc8inx 7359 6 in in IN cord-010092-uftc8inx 7359 7 IL-8 il-8 NN cord-010092-uftc8inx 7359 8 levels level NNS cord-010092-uftc8inx 7359 9 by by IN cord-010092-uftc8inx 7359 10 hours hour NNS cord-010092-uftc8inx 7359 11 in in IN cord-010092-uftc8inx 7359 12 the the DT cord-010092-uftc8inx 7359 13 two two CD cord-010092-uftc8inx 7359 14 PRP PRP NNP cord-010092-uftc8inx 7359 15 groups group NNS cord-010092-uftc8inx 7359 16 by by IN cord-010092-uftc8inx 7359 17 ELISA ELISA NNP cord-010092-uftc8inx 7359 18 method method NN cord-010092-uftc8inx 7359 19 , , , cord-010092-uftc8inx 7359 20 no no DT cord-010092-uftc8inx 7359 21 antifungal antifungal JJ cord-010092-uftc8inx 7359 22 effect effect NN cord-010092-uftc8inx 7359 23 was be VBD cord-010092-uftc8inx 7359 24 detected detect VBN cord-010092-uftc8inx 7359 25 against against IN cord-010092-uftc8inx 7359 26 C. C. NNP cord-010092-uftc8inx 7359 27 albicans albican NNS cord-010092-uftc8inx 7359 28 . . . cord-010092-uftc8inx 7360 1 It -PRON- PRP cord-010092-uftc8inx 7360 2 was be VBD cord-010092-uftc8inx 7360 3 observed observe VBN cord-010092-uftc8inx 7360 4 that that DT cord-010092-uftc8inx 7360 5 decrease decrease NN cord-010092-uftc8inx 7360 6 in in IN cord-010092-uftc8inx 7360 7 TMSB4 TMSB4 NNS cord-010092-uftc8inx 7360 8 values value NNS cord-010092-uftc8inx 7360 9 results result NNS cord-010092-uftc8inx 7360 10 from from IN cord-010092-uftc8inx 7360 11 the the DT cord-010092-uftc8inx 7360 12 antifungal antifungal JJ cord-010092-uftc8inx 7360 13 activity activity NN cord-010092-uftc8inx 7360 14 on on IN cord-010092-uftc8inx 7360 15 the the DT cord-010092-uftc8inx 7360 16 advancing advance VBG cord-010092-uftc8inx 7360 17 hours hour NNS cord-010092-uftc8inx 7360 18 in in IN cord-010092-uftc8inx 7360 19 the the DT cord-010092-uftc8inx 7360 20 PRP PRP NNP cord-010092-uftc8inx 7360 21 groups group NNS cord-010092-uftc8inx 7360 22 . . . cord-010092-uftc8inx 7361 1 Whereas whereas IN cord-010092-uftc8inx 7361 2 PF-4 PF-4 NNP cord-010092-uftc8inx 7361 3 did do VBD cord-010092-uftc8inx 7361 4 not not RB cord-010092-uftc8inx 7361 5 act act VB cord-010092-uftc8inx 7361 6 an an DT cord-010092-uftc8inx 7361 7 antifungal antifungal JJ cord-010092-uftc8inx 7361 8 activity activity NN cord-010092-uftc8inx 7361 9 on on IN cord-010092-uftc8inx 7361 10 PRP-10 PRP-10 NNP cord-010092-uftc8inx 7361 11 3 3 CD cord-010092-uftc8inx 7361 12 and and CC cord-010092-uftc8inx 7361 13 PRP-10 PRP-10 NNP cord-010092-uftc8inx 7361 14 4 4 CD cord-010092-uftc8inx 7361 15 . . . cord-010092-uftc8inx 7362 1 Summary Summary NNP cord-010092-uftc8inx 7362 2 / / SYM cord-010092-uftc8inx 7362 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 7362 4 : : : cord-010092-uftc8inx 7363 1 Even even RB cord-010092-uftc8inx 7363 2 in in IN cord-010092-uftc8inx 7363 3 our -PRON- PRP$ cord-010092-uftc8inx 7363 4 study study NN cord-010092-uftc8inx 7363 5 group group NN cord-010092-uftc8inx 7363 6 where where WRB cord-010092-uftc8inx 7363 7 the the DT cord-010092-uftc8inx 7363 8 highest high JJS cord-010092-uftc8inx 7363 9 platelet platelet NN cord-010092-uftc8inx 7363 10 counts count NNS cord-010092-uftc8inx 7363 11 were be VBD cord-010092-uftc8inx 7363 12 obtained obtain VBN cord-010092-uftc8inx 7363 13 at at IN cord-010092-uftc8inx 7363 14 the the DT cord-010092-uftc8inx 7363 15 lowest low JJS cord-010092-uftc8inx 7363 16 concentration concentration NN cord-010092-uftc8inx 7363 17 , , , cord-010092-uftc8inx 7363 18 C. C. NNP cord-010092-uftc8inx 7363 19 albicans albican NNS cord-010092-uftc8inx 7363 20 reproduction reproduction NN cord-010092-uftc8inx 7363 21 could could MD cord-010092-uftc8inx 7363 22 not not RB cord-010092-uftc8inx 7363 23 completely completely RB cord-010092-uftc8inx 7363 24 eliminated eliminate VBN cord-010092-uftc8inx 7363 25 as as IN cord-010092-uftc8inx 7363 26 mentioned mention VBN cord-010092-uftc8inx 7363 27 in in IN cord-010092-uftc8inx 7363 28 the the DT cord-010092-uftc8inx 7363 29 literature literature NN cord-010092-uftc8inx 7363 30 . . . cord-010092-uftc8inx 7364 1 Repeated repeat VBN cord-010092-uftc8inx 7364 2 doses dose NNS cord-010092-uftc8inx 7364 3 of of IN cord-010092-uftc8inx 7364 4 PRP PRP NNP cord-010092-uftc8inx 7364 5 applications application NNS cord-010092-uftc8inx 7364 6 , , , cord-010092-uftc8inx 7364 7 such such JJ cord-010092-uftc8inx 7364 8 as as IN cord-010092-uftc8inx 7364 9 drugs drug NNS cord-010092-uftc8inx 7364 10 used use VBN cord-010092-uftc8inx 7364 11 in in IN cord-010092-uftc8inx 7364 12 patients patient NNS cord-010092-uftc8inx 7364 13 , , , cord-010092-uftc8inx 7364 14 may may MD cord-010092-uftc8inx 7364 15 have have VB cord-010092-uftc8inx 7364 16 longer long JJR cord-010092-uftc8inx 7364 17 duration duration NN cord-010092-uftc8inx 7364 18 of of IN cord-010092-uftc8inx 7364 19 action action NN cord-010092-uftc8inx 7364 20 and and CC cord-010092-uftc8inx 7364 21 even even RB cord-010092-uftc8inx 7364 22 complete complete JJ cord-010092-uftc8inx 7364 23 repression repression NN cord-010092-uftc8inx 7364 24 of of IN cord-010092-uftc8inx 7364 25 reproductive reproductive JJ cord-010092-uftc8inx 7364 26 outcomes outcome NNS cord-010092-uftc8inx 7364 27 . . . cord-010092-uftc8inx 7365 1 Background background NN cord-010092-uftc8inx 7365 2 : : : cord-010092-uftc8inx 7365 3 Generally generally RB cord-010092-uftc8inx 7365 4 , , , cord-010092-uftc8inx 7365 5 blood blood NN cord-010092-uftc8inx 7365 6 is be VBZ cord-010092-uftc8inx 7365 7 available available JJ cord-010092-uftc8inx 7365 8 in in IN cord-010092-uftc8inx 7365 9 developed develop VBN cord-010092-uftc8inx 7365 10 countries country NNS cord-010092-uftc8inx 7365 11 for for IN cord-010092-uftc8inx 7365 12 transfusion transfusion NN cord-010092-uftc8inx 7365 13 . . . cord-010092-uftc8inx 7366 1 Sometimes sometimes RB cord-010092-uftc8inx 7366 2 , , , cord-010092-uftc8inx 7366 3 transfused transfuse VBN cord-010092-uftc8inx 7366 4 or or CC cord-010092-uftc8inx 7366 5 previously previously RB cord-010092-uftc8inx 7366 6 pregnant pregnant JJ cord-010092-uftc8inx 7366 7 patients patient NNS cord-010092-uftc8inx 7366 8 form form VBP cord-010092-uftc8inx 7366 9 alloantibodies alloantibody NNS cord-010092-uftc8inx 7366 10 to to IN cord-010092-uftc8inx 7366 11 red red JJ cord-010092-uftc8inx 7366 12 cell cell NN cord-010092-uftc8inx 7366 13 antigens antigen NNS cord-010092-uftc8inx 7366 14 and and CC cord-010092-uftc8inx 7366 15 rarely rarely RB cord-010092-uftc8inx 7366 16 , , , cord-010092-uftc8inx 7366 17 to to IN cord-010092-uftc8inx 7366 18 antigens antigen NNS cord-010092-uftc8inx 7366 19 of of IN cord-010092-uftc8inx 7366 20 high high JJ cord-010092-uftc8inx 7366 21 prevalence prevalence NN cord-010092-uftc8inx 7366 22 . . . cord-010092-uftc8inx 7367 1 This this DT cord-010092-uftc8inx 7367 2 case case NN cord-010092-uftc8inx 7367 3 focuses focus VBZ cord-010092-uftc8inx 7367 4 on on IN cord-010092-uftc8inx 7367 5 a a DT cord-010092-uftc8inx 7367 6 twoyear twoyear JJ cord-010092-uftc8inx 7367 7 - - HYPH cord-010092-uftc8inx 7367 8 old old JJ cord-010092-uftc8inx 7367 9 girl girl NN cord-010092-uftc8inx 7367 10 , , , cord-010092-uftc8inx 7367 11 of of IN cord-010092-uftc8inx 7367 12 Pakistani pakistani JJ cord-010092-uftc8inx 7367 13 descent descent NN cord-010092-uftc8inx 7367 14 , , , cord-010092-uftc8inx 7367 15 diagnosed diagnose VBN cord-010092-uftc8inx 7367 16 with with IN cord-010092-uftc8inx 7367 17 neuroblastoma neuroblastoma NN cord-010092-uftc8inx 7367 18 stage stage NN cord-010092-uftc8inx 7367 19 IV IV NNP cord-010092-uftc8inx 7367 20 with with IN cord-010092-uftc8inx 7367 21 anti anti JJ cord-010092-uftc8inx 7367 22 - - JJ cord-010092-uftc8inx 7367 23 In in NN cord-010092-uftc8inx 7367 24 b b NN cord-010092-uftc8inx 7368 1 and and CC cord-010092-uftc8inx 7368 2 -E. -E. VBD cord-010092-uftc8inx 7369 1 Although although IN cord-010092-uftc8inx 7369 2 the the DT cord-010092-uftc8inx 7369 3 publications publication NNS cord-010092-uftc8inx 7369 4 indicate indicate VBP cord-010092-uftc8inx 7369 5 that that IN cord-010092-uftc8inx 7369 6 4 4 CD cord-010092-uftc8inx 7369 7 % % NN cord-010092-uftc8inx 7369 8 of of IN cord-010092-uftc8inx 7369 9 the the DT cord-010092-uftc8inx 7369 10 Pakistani pakistani JJ cord-010092-uftc8inx 7369 11 , , , cord-010092-uftc8inx 7369 12 Indian indian JJ cord-010092-uftc8inx 7369 13 or or CC cord-010092-uftc8inx 7369 14 Iranian iranian JJ cord-010092-uftc8inx 7369 15 populations population NNS cord-010092-uftc8inx 7369 16 are be VBP cord-010092-uftc8inx 7369 17 In(b- in(b- CD cord-010092-uftc8inx 7369 18 ) ) -RRB- cord-010092-uftc8inx 7369 19 , , , cord-010092-uftc8inx 7369 20 it -PRON- PRP cord-010092-uftc8inx 7369 21 was be VBD cord-010092-uftc8inx 7369 22 discovered discover VBN cord-010092-uftc8inx 7369 23 that that IN cord-010092-uftc8inx 7369 24 this this DT cord-010092-uftc8inx 7369 25 blood blood NN cord-010092-uftc8inx 7369 26 type type NN cord-010092-uftc8inx 7369 27 is be VBZ cord-010092-uftc8inx 7369 28 exceedingly exceedingly RB cord-010092-uftc8inx 7369 29 rare rare JJ cord-010092-uftc8inx 7369 30 . . . cord-010092-uftc8inx 7370 1 An an DT cord-010092-uftc8inx 7370 2 international international JJ cord-010092-uftc8inx 7370 3 search search NN cord-010092-uftc8inx 7370 4 was be VBD cord-010092-uftc8inx 7370 5 required require VBN cord-010092-uftc8inx 7370 6 to to TO cord-010092-uftc8inx 7370 7 ensure ensure VB cord-010092-uftc8inx 7370 8 blood blood NN cord-010092-uftc8inx 7370 9 product product NN cord-010092-uftc8inx 7370 10 availability availability NN cord-010092-uftc8inx 7370 11 for for IN cord-010092-uftc8inx 7370 12 chemotherapy chemotherapy NN cord-010092-uftc8inx 7370 13 and and CC cord-010092-uftc8inx 7370 14 autologous autologous JJ cord-010092-uftc8inx 7370 15 hematopoietic hematopoietic JJ cord-010092-uftc8inx 7370 16 progenitor progenitor NN cord-010092-uftc8inx 7370 17 cell cell NN cord-010092-uftc8inx 7370 18 transplants transplant NNS cord-010092-uftc8inx 7370 19 Aims aim VBZ cord-010092-uftc8inx 7370 20 : : : cord-010092-uftc8inx 7371 1 Illustrate illustrate VB cord-010092-uftc8inx 7371 2 the the DT cord-010092-uftc8inx 7371 3 response response NN cord-010092-uftc8inx 7371 4 of of IN cord-010092-uftc8inx 7371 5 the the DT cord-010092-uftc8inx 7371 6 public public NN cord-010092-uftc8inx 7371 7 to to IN cord-010092-uftc8inx 7371 8 a a DT cord-010092-uftc8inx 7371 9 powerful powerful JJ cord-010092-uftc8inx 7371 10 story story NN cord-010092-uftc8inx 7371 11 of of IN cord-010092-uftc8inx 7371 12 a a DT cord-010092-uftc8inx 7371 13 child child NN cord-010092-uftc8inx 7371 14 needing need VBG cord-010092-uftc8inx 7371 15 rare rare JJ cord-010092-uftc8inx 7371 16 blood blood NN cord-010092-uftc8inx 7371 17 for for IN cord-010092-uftc8inx 7371 18 treatment treatment NN cord-010092-uftc8inx 7371 19 and and CC cord-010092-uftc8inx 7371 20 international international JJ cord-010092-uftc8inx 7371 21 collaboration collaboration NN cord-010092-uftc8inx 7371 22 for for IN cord-010092-uftc8inx 7371 23 provision provision NN cord-010092-uftc8inx 7371 24 of of IN cord-010092-uftc8inx 7371 25 very very RB cord-010092-uftc8inx 7371 26 rare rare JJ cord-010092-uftc8inx 7371 27 units unit NNS cord-010092-uftc8inx 7371 28 . . . cord-010092-uftc8inx 7372 1 Methods Methods NNPS cord-010092-uftc8inx 7372 2 Case Case NNP cord-010092-uftc8inx 7372 3 Report Report NNP cord-010092-uftc8inx 7372 4 : : : cord-010092-uftc8inx 7372 5 A a DT cord-010092-uftc8inx 7372 6 two two CD cord-010092-uftc8inx 7372 7 - - HYPH cord-010092-uftc8inx 7372 8 year year NN cord-010092-uftc8inx 7372 9 - - HYPH cord-010092-uftc8inx 7372 10 old old JJ cord-010092-uftc8inx 7372 11 patient patient NN cord-010092-uftc8inx 7372 12 's 's POS cord-010092-uftc8inx 7372 13 sample sample NN cord-010092-uftc8inx 7372 14 was be VBD cord-010092-uftc8inx 7372 15 referred refer VBN cord-010092-uftc8inx 7372 16 for for IN cord-010092-uftc8inx 7372 17 antibody antibody NN cord-010092-uftc8inx 7372 18 identification identification NN cord-010092-uftc8inx 7372 19 . . . cord-010092-uftc8inx 7373 1 The the DT cord-010092-uftc8inx 7373 2 patient patient NN cord-010092-uftc8inx 7373 3 had have VBD cord-010092-uftc8inx 7373 4 received receive VBN cord-010092-uftc8inx 7373 5 four four CD cord-010092-uftc8inx 7373 6 transfusions transfusion NNS cord-010092-uftc8inx 7373 7 ( ( -LRB- cord-010092-uftc8inx 7373 8 883 883 CD cord-010092-uftc8inx 7373 9 mL ml NN cord-010092-uftc8inx 7373 10 of of IN cord-010092-uftc8inx 7373 11 red red JJ cord-010092-uftc8inx 7373 12 cells cell NNS cord-010092-uftc8inx 7373 13 ) ) -RRB- cord-010092-uftc8inx 7373 14 in in IN cord-010092-uftc8inx 7373 15 the the DT cord-010092-uftc8inx 7373 16 preceding precede VBG cord-010092-uftc8inx 7373 17 10-day 10-day CD cord-010092-uftc8inx 7373 18 period period NN cord-010092-uftc8inx 7373 19 . . . cord-010092-uftc8inx 7374 1 Hgb Hgb NNP cord-010092-uftc8inx 7374 2 level level NN cord-010092-uftc8inx 7374 3 fluctuations fluctuation NNS cord-010092-uftc8inx 7374 4 were be VBD cord-010092-uftc8inx 7374 5 consistent consistent JJ cord-010092-uftc8inx 7374 6 with with IN cord-010092-uftc8inx 7374 7 decreased decrease VBN cord-010092-uftc8inx 7374 8 transfused transfuse VBN cord-010092-uftc8inx 7374 9 red red JJ cord-010092-uftc8inx 7374 10 cell cell NN cord-010092-uftc8inx 7374 11 survival survival NN cord-010092-uftc8inx 7374 12 . . . cord-010092-uftc8inx 7375 1 Following follow VBG cord-010092-uftc8inx 7375 2 the the DT cord-010092-uftc8inx 7375 3 last last JJ cord-010092-uftc8inx 7375 4 transfusion transfusion NN cord-010092-uftc8inx 7375 5 of of IN cord-010092-uftc8inx 7375 6 225 225 CD cord-010092-uftc8inx 7375 7 mL ml NN cord-010092-uftc8inx 7375 8 , , , cord-010092-uftc8inx 7375 9 the the DT cord-010092-uftc8inx 7375 10 hemoglobin hemoglobin NN cord-010092-uftc8inx 7375 11 decreased decrease VBD cord-010092-uftc8inx 7375 12 from from IN cord-010092-uftc8inx 7375 13 8.6 8.6 CD cord-010092-uftc8inx 7375 14 to to IN cord-010092-uftc8inx 7375 15 5.8 5.8 CD cord-010092-uftc8inx 7375 16 . . . cord-010092-uftc8inx 7376 1 Anti Anti NNP cord-010092-uftc8inx 7376 2 - - HYPH cord-010092-uftc8inx 7376 3 In in NN cord-010092-uftc8inx 7376 4 b b NN cord-010092-uftc8inx 7376 5 , , , cord-010092-uftc8inx 7376 6 and and CC cord-010092-uftc8inx 7376 7 a a DT cord-010092-uftc8inx 7376 8 ficin ficin NNS cord-010092-uftc8inx 7376 9 - - HYPH cord-010092-uftc8inx 7376 10 only only RB cord-010092-uftc8inx 7376 11 reactive reactive JJ cord-010092-uftc8inx 7376 12 anti anti JJ cord-010092-uftc8inx 7376 13 - - NN cord-010092-uftc8inx 7376 14 E E NNP cord-010092-uftc8inx 7376 15 was be VBD cord-010092-uftc8inx 7376 16 identified identify VBN cord-010092-uftc8inx 7376 17 in in IN cord-010092-uftc8inx 7376 18 the the DT cord-010092-uftc8inx 7376 19 serum serum NN cord-010092-uftc8inx 7376 20 and and CC cord-010092-uftc8inx 7376 21 anti anti NN cord-010092-uftc8inx 7376 22 - - NN cord-010092-uftc8inx 7376 23 In in NN cord-010092-uftc8inx 7376 24 b b NN cord-010092-uftc8inx 7376 25 in in IN cord-010092-uftc8inx 7376 26 the the DT cord-010092-uftc8inx 7376 27 eluate eluate NN cord-010092-uftc8inx 7376 28 . . . cord-010092-uftc8inx 7377 1 The the DT cord-010092-uftc8inx 7377 2 Monocyte Monocyte NNP cord-010092-uftc8inx 7377 3 Monolayer Monolayer NNP cord-010092-uftc8inx 7377 4 Assay Assay NNP cord-010092-uftc8inx 7377 5 predicted predict VBD cord-010092-uftc8inx 7377 6 the the DT cord-010092-uftc8inx 7377 7 anti anti NN cord-010092-uftc8inx 7377 8 - - JJ cord-010092-uftc8inx 7377 9 In in JJ cord-010092-uftc8inx 7377 10 b b NN cord-010092-uftc8inx 7377 11 to to TO cord-010092-uftc8inx 7377 12 be be VB cord-010092-uftc8inx 7377 13 clinically clinically RB cord-010092-uftc8inx 7377 14 significant significant JJ cord-010092-uftc8inx 7377 15 ( ( -LRB- cord-010092-uftc8inx 7377 16 68 68 CD cord-010092-uftc8inx 7377 17 % % NN cord-010092-uftc8inx 7377 18 reactivity reactivity NN cord-010092-uftc8inx 7377 19 ) ) -RRB- cord-010092-uftc8inx 7377 20 . . . cord-010092-uftc8inx 7378 1 Transfusion transfusion NN cord-010092-uftc8inx 7378 2 of of IN cord-010092-uftc8inx 7378 3 antigen antigen NN cord-010092-uftc8inx 7378 4 neg neg JJ cord-010092-uftc8inx 7378 5 units unit NNS cord-010092-uftc8inx 7378 6 once once RB cord-010092-uftc8inx 7378 7 obtained obtain VBN cord-010092-uftc8inx 7378 8 , , , cord-010092-uftc8inx 7378 9 resulted result VBD cord-010092-uftc8inx 7378 10 in in IN cord-010092-uftc8inx 7378 11 a a DT cord-010092-uftc8inx 7378 12 stable stable JJ cord-010092-uftc8inx 7378 13 transfusion transfusion NN cord-010092-uftc8inx 7378 14 response response NN cord-010092-uftc8inx 7378 15 . . . cord-010092-uftc8inx 7379 1 Although although IN cord-010092-uftc8inx 7379 2 it -PRON- PRP cord-010092-uftc8inx 7379 3 was be VBD cord-010092-uftc8inx 7379 4 expected expect VBN cord-010092-uftc8inx 7379 5 that that IN cord-010092-uftc8inx 7379 6 In(b- in(b- CD cord-010092-uftc8inx 7379 7 ) ) -RRB- cord-010092-uftc8inx 7379 8 blood blood NN cord-010092-uftc8inx 7379 9 would would MD cord-010092-uftc8inx 7379 10 be be VB cord-010092-uftc8inx 7379 11 more more RBR cord-010092-uftc8inx 7379 12 easily easily RB cord-010092-uftc8inx 7379 13 sourced source VBN cord-010092-uftc8inx 7379 14 , , , cord-010092-uftc8inx 7379 15 only only RB cord-010092-uftc8inx 7379 16 two two CD cord-010092-uftc8inx 7379 17 donors donor NNS cord-010092-uftc8inx 7379 18 in in IN cord-010092-uftc8inx 7379 19 the the DT cord-010092-uftc8inx 7379 20 USA USA NNP cord-010092-uftc8inx 7379 21 were be VBD cord-010092-uftc8inx 7380 1 In in IN cord-010092-uftc8inx 7380 2 ( ( -LRB- cord-010092-uftc8inx 7380 3 b- b- NN cord-010092-uftc8inx 7380 4 ) ) -RRB- cord-010092-uftc8inx 7380 5 E- E- NNP cord-010092-uftc8inx 7380 6 . . . cord-010092-uftc8inx 7381 1 As as IN cord-010092-uftc8inx 7381 2 7 7 CD cord-010092-uftc8inx 7381 3 - - SYM cord-010092-uftc8inx 7381 4 10 10 CD cord-010092-uftc8inx 7381 5 units unit NNS cord-010092-uftc8inx 7381 6 of of IN cord-010092-uftc8inx 7381 7 blood blood NN cord-010092-uftc8inx 7381 8 were be VBD cord-010092-uftc8inx 7381 9 requested request VBN cord-010092-uftc8inx 7381 10 for for IN cord-010092-uftc8inx 7381 11 the the DT cord-010092-uftc8inx 7381 12 post post JJ cord-010092-uftc8inx 7381 13 - - JJ cord-010092-uftc8inx 7381 14 transplant transplant JJ cord-010092-uftc8inx 7381 15 period period NN cord-010092-uftc8inx 7381 16 , , , cord-010092-uftc8inx 7381 17 a a DT cord-010092-uftc8inx 7381 18 national national JJ cord-010092-uftc8inx 7381 19 and and CC cord-010092-uftc8inx 7381 20 international international JJ cord-010092-uftc8inx 7381 21 search search NN cord-010092-uftc8inx 7381 22 was be VBD cord-010092-uftc8inx 7381 23 initiated initiate VBN cord-010092-uftc8inx 7381 24 , , , cord-010092-uftc8inx 7381 25 as as IN cord-010092-uftc8inx 7381 26 was be VBD cord-010092-uftc8inx 7381 27 a a DT cord-010092-uftc8inx 7381 28 robust robust JJ cord-010092-uftc8inx 7381 29 media medium NNS cord-010092-uftc8inx 7381 30 appeal appeal NN cord-010092-uftc8inx 7381 31 to to IN cord-010092-uftc8inx 7381 32 donors donor NNS cord-010092-uftc8inx 7381 33 resulting result VBG cord-010092-uftc8inx 7381 34 in in IN cord-010092-uftc8inx 7381 35 many many JJ cord-010092-uftc8inx 7381 36 donors donor NNS cord-010092-uftc8inx 7381 37 for for IN cord-010092-uftc8inx 7381 38 an an DT cord-010092-uftc8inx 7381 39 intense intense JJ cord-010092-uftc8inx 7381 40 domestic domestic JJ cord-010092-uftc8inx 7381 41 screening screening NN cord-010092-uftc8inx 7381 42 effort effort NN cord-010092-uftc8inx 7381 43 in in IN cord-010092-uftc8inx 7381 44 the the DT cord-010092-uftc8inx 7381 45 USA USA NNP cord-010092-uftc8inx 7381 46 . . . cord-010092-uftc8inx 7382 1 The the DT cord-010092-uftc8inx 7382 2 search search NN cord-010092-uftc8inx 7382 3 of of IN cord-010092-uftc8inx 7382 4 the the DT cord-010092-uftc8inx 7382 5 WHO WHO NNP cord-010092-uftc8inx 7382 6 International International NNP cord-010092-uftc8inx 7382 7 Rare Rare NNP cord-010092-uftc8inx 7382 8 Donor Donor NNP cord-010092-uftc8inx 7382 9 Panel Panel NNP cord-010092-uftc8inx 7382 10 by by IN cord-010092-uftc8inx 7382 11 the the DT cord-010092-uftc8inx 7382 12 International International NNP cord-010092-uftc8inx 7382 13 Blood Blood NNP cord-010092-uftc8inx 7382 14 Group Group NNP cord-010092-uftc8inx 7382 15 Reference Reference NNP cord-010092-uftc8inx 7382 16 Laboratory Laboratory NNP cord-010092-uftc8inx 7382 17 revealed reveal VBD cord-010092-uftc8inx 7382 18 three three CD cord-010092-uftc8inx 7382 19 known know VBN cord-010092-uftc8inx 7382 20 In(b- in(b- CD cord-010092-uftc8inx 7382 21 ) ) -RRB- cord-010092-uftc8inx 7382 22 E E NNS cord-010092-uftc8inx 7382 23 - - NNS cord-010092-uftc8inx 7382 24 donors donor NNS cord-010092-uftc8inx 7382 25 ; ; : cord-010092-uftc8inx 7382 26 two two CD cord-010092-uftc8inx 7382 27 British british JJ cord-010092-uftc8inx 7382 28 and and CC cord-010092-uftc8inx 7382 29 one one CD cord-010092-uftc8inx 7382 30 Australian australian JJ cord-010092-uftc8inx 7382 31 . . . cord-010092-uftc8inx 7383 1 They -PRON- PRP cord-010092-uftc8inx 7383 2 were be VBD cord-010092-uftc8inx 7383 3 contacted contact VBN cord-010092-uftc8inx 7383 4 , , , cord-010092-uftc8inx 7383 5 recruited recruit VBN cord-010092-uftc8inx 7383 6 , , , cord-010092-uftc8inx 7383 7 collected collect VBN cord-010092-uftc8inx 7383 8 and and CC cord-010092-uftc8inx 7383 9 shipped ship VBN cord-010092-uftc8inx 7383 10 to to IN cord-010092-uftc8inx 7383 11 the the DT cord-010092-uftc8inx 7383 12 USA USA NNP cord-010092-uftc8inx 7383 13 with with IN cord-010092-uftc8inx 7383 14 the the DT cord-010092-uftc8inx 7383 15 work work NN cord-010092-uftc8inx 7383 16 of of IN cord-010092-uftc8inx 7383 17 the the DT cord-010092-uftc8inx 7383 18 American American NNP cord-010092-uftc8inx 7383 19 Rare Rare NNP cord-010092-uftc8inx 7383 20 Donor Donor NNP cord-010092-uftc8inx 7383 21 Program Program NNP cord-010092-uftc8inx 7383 22 ( ( -LRB- cord-010092-uftc8inx 7383 23 ARDP ARDP NNP cord-010092-uftc8inx 7383 24 ) ) -RRB- cord-010092-uftc8inx 7383 25 staff staff NN cord-010092-uftc8inx 7383 26 and and CC cord-010092-uftc8inx 7383 27 the the DT cord-010092-uftc8inx 7383 28 ISBT ISBT NNP cord-010092-uftc8inx 7383 29 Working Working NNP cord-010092-uftc8inx 7383 30 Party Party NNP cord-010092-uftc8inx 7383 31 on on IN cord-010092-uftc8inx 7383 32 Rare Rare NNP cord-010092-uftc8inx 7383 33 Donors Donors NNPS cord-010092-uftc8inx 7383 34 ( ( -LRB- cord-010092-uftc8inx 7383 35 ISBT ISBT NNP cord-010092-uftc8inx 7383 36 WPRD WPRD NNP cord-010092-uftc8inx 7383 37 ) ) -RRB- cord-010092-uftc8inx 7383 38 members member NNS cord-010092-uftc8inx 7383 39 in in IN cord-010092-uftc8inx 7383 40 each each DT cord-010092-uftc8inx 7383 41 of of IN cord-010092-uftc8inx 7383 42 the the DT cord-010092-uftc8inx 7383 43 countries country NNS cord-010092-uftc8inx 7383 44 . . . cord-010092-uftc8inx 7384 1 Results result NNS cord-010092-uftc8inx 7384 2 : : : cord-010092-uftc8inx 7385 1 The the DT cord-010092-uftc8inx 7385 2 intense intense JJ cord-010092-uftc8inx 7385 3 media medium NNS cord-010092-uftc8inx 7385 4 coverage coverage NN cord-010092-uftc8inx 7385 5 of of IN cord-010092-uftc8inx 7385 6 OneBlood OneBlood NNP cord-010092-uftc8inx 7385 7 ( ( -LRB- cord-010092-uftc8inx 7385 8 the the DT cord-010092-uftc8inx 7385 9 Florida Florida NNP cord-010092-uftc8inx 7385 10 blood blood NN cord-010092-uftc8inx 7385 11 center center NN cord-010092-uftc8inx 7385 12 collaborating collaborate VBG cord-010092-uftc8inx 7385 13 on on IN cord-010092-uftc8inx 7385 14 treatment treatment NN cord-010092-uftc8inx 7385 15 with with IN cord-010092-uftc8inx 7385 16 the the DT cord-010092-uftc8inx 7385 17 hospital hospital NN cord-010092-uftc8inx 7385 18 ) ) -RRB- cord-010092-uftc8inx 7385 19 included include VBD cord-010092-uftc8inx 7385 20 online online JJ cord-010092-uftc8inx 7385 21 news news NN cord-010092-uftc8inx 7385 22 outlets outlet NNS cord-010092-uftc8inx 7385 23 ( ( -LRB- cord-010092-uftc8inx 7385 24 YouTube YouTube NNP cord-010092-uftc8inx 7385 25 , , , cord-010092-uftc8inx 7385 26 Facebook Facebook NNP cord-010092-uftc8inx 7385 27 ) ) -RRB- cord-010092-uftc8inx 7385 28 resulted result VBD cord-010092-uftc8inx 7385 29 in in IN cord-010092-uftc8inx 7385 30 over over IN cord-010092-uftc8inx 7385 31 27,000 27,000 CD cord-010092-uftc8inx 7385 32 responses response NNS cord-010092-uftc8inx 7385 33 from from IN cord-010092-uftc8inx 7385 34 national national JJ cord-010092-uftc8inx 7385 35 and and CC cord-010092-uftc8inx 7385 36 international international JJ cord-010092-uftc8inx 7385 37 potential potential JJ cord-010092-uftc8inx 7385 38 donors donor NNS cord-010092-uftc8inx 7385 39 to to TO cord-010092-uftc8inx 7385 40 be be VB cord-010092-uftc8inx 7385 41 tested test VBN cord-010092-uftc8inx 7385 42 for for IN cord-010092-uftc8inx 7385 43 In in IN cord-010092-uftc8inx 7385 44 b b NN cord-010092-uftc8inx 7385 45 . . . cord-010092-uftc8inx 7386 1 ISBT ISBT NNP cord-010092-uftc8inx 7386 2 WPRD WPRD NNP cord-010092-uftc8inx 7386 3 members member NNS cord-010092-uftc8inx 7386 4 were be VBD cord-010092-uftc8inx 7386 5 sent send VBN cord-010092-uftc8inx 7386 6 the the DT cord-010092-uftc8inx 7386 7 web web NN cord-010092-uftc8inx 7386 8 information information NN cord-010092-uftc8inx 7386 9 of of IN cord-010092-uftc8inx 7386 10 potential potential JJ cord-010092-uftc8inx 7386 11 donors donor NNS cord-010092-uftc8inx 7386 12 identified identify VBN cord-010092-uftc8inx 7386 13 in in IN cord-010092-uftc8inx 7386 14 their -PRON- PRP$ cord-010092-uftc8inx 7386 15 countries country NNS cord-010092-uftc8inx 7386 16 by by IN cord-010092-uftc8inx 7386 17 the the DT cord-010092-uftc8inx 7386 18 ARDP ARDP NNP cord-010092-uftc8inx 7386 19 . . . cord-010092-uftc8inx 7387 1 Over over IN cord-010092-uftc8inx 7387 2 3,500 3,500 CD cord-010092-uftc8inx 7387 3 samples sample NNS cord-010092-uftc8inx 7387 4 from from IN cord-010092-uftc8inx 7387 5 75 75 CD cord-010092-uftc8inx 7387 6 blood blood NN cord-010092-uftc8inx 7387 7 centers center NNS cord-010092-uftc8inx 7387 8 and and CC cord-010092-uftc8inx 7387 9 associated associate VBN cord-010092-uftc8inx 7387 10 laboratories laboratory NNS cord-010092-uftc8inx 7387 11 tested test VBN cord-010092-uftc8inx 7387 12 with with IN cord-010092-uftc8inx 7387 13 anti anti JJ cord-010092-uftc8inx 7387 14 - - JJ cord-010092-uftc8inx 7387 15 In in NN cord-010092-uftc8inx 7387 16 b b NN cord-010092-uftc8inx 7387 17 by by IN cord-010092-uftc8inx 7387 18 OneBlood OneBlood NNP cord-010092-uftc8inx 7387 19 . . . cord-010092-uftc8inx 7388 1 Two two CD cord-010092-uftc8inx 7388 2 new new JJ cord-010092-uftc8inx 7388 3 In(b- in(b- CD cord-010092-uftc8inx 7388 4 ) ) -RRB- cord-010092-uftc8inx 7388 5 donors donor NNS cord-010092-uftc8inx 7388 6 were be VBD cord-010092-uftc8inx 7388 7 discovered discover VBN cord-010092-uftc8inx 7388 8 ( ( -LRB- cord-010092-uftc8inx 7388 9 0.06 0.06 CD cord-010092-uftc8inx 7388 10 % % NN cord-010092-uftc8inx 7388 11 ) ) -RRB- cord-010092-uftc8inx 7388 12 ; ; : cord-010092-uftc8inx 7388 13 but but CC cord-010092-uftc8inx 7388 14 both both DT cord-010092-uftc8inx 7388 15 typed type VBN cord-010092-uftc8inx 7388 16 E+ E+ NNP cord-010092-uftc8inx 7388 17 , , , cord-010092-uftc8inx 7388 18 thus thus RB cord-010092-uftc8inx 7388 19 were be VBD cord-010092-uftc8inx 7388 20 not not RB cord-010092-uftc8inx 7388 21 a a DT cord-010092-uftc8inx 7388 22 match match NN cord-010092-uftc8inx 7388 23 for for IN cord-010092-uftc8inx 7388 24 the the DT cord-010092-uftc8inx 7388 25 child child NN cord-010092-uftc8inx 7388 26 . . . cord-010092-uftc8inx 7389 1 Summary Summary NNP cord-010092-uftc8inx 7389 2 / / SYM cord-010092-uftc8inx 7389 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 7389 4 : : : cord-010092-uftc8inx 7390 1 This this DT cord-010092-uftc8inx 7390 2 intense intense JJ cord-010092-uftc8inx 7390 3 media medium NNS cord-010092-uftc8inx 7390 4 coverage coverage NN cord-010092-uftc8inx 7390 5 and and CC cord-010092-uftc8inx 7390 6 the the DT cord-010092-uftc8inx 7390 7 overwhelming overwhelming JJ cord-010092-uftc8inx 7390 8 donor donor NN cord-010092-uftc8inx 7390 9 response response NN cord-010092-uftc8inx 7390 10 was be VBD cord-010092-uftc8inx 7390 11 unprecedented unprecedented JJ cord-010092-uftc8inx 7390 12 in in IN cord-010092-uftc8inx 7390 13 our -PRON- PRP$ cord-010092-uftc8inx 7390 14 experience experience NN cord-010092-uftc8inx 7390 15 . . . cord-010092-uftc8inx 7391 1 The the DT cord-010092-uftc8inx 7391 2 coordination coordination NN cord-010092-uftc8inx 7391 3 and and CC cord-010092-uftc8inx 7391 4 cooperation cooperation NN cord-010092-uftc8inx 7391 5 among among IN cord-010092-uftc8inx 7391 6 the the DT cord-010092-uftc8inx 7391 7 numerous numerous JJ cord-010092-uftc8inx 7391 8 blood blood NN cord-010092-uftc8inx 7391 9 centers center NNS cord-010092-uftc8inx 7391 10 reflect reflect VBP cord-010092-uftc8inx 7391 11 the the DT cord-010092-uftc8inx 7391 12 deep deep JJ cord-010092-uftc8inx 7391 13 dedication dedication NN cord-010092-uftc8inx 7391 14 of of IN cord-010092-uftc8inx 7391 15 the the DT cord-010092-uftc8inx 7391 16 Blood Blood NNP cord-010092-uftc8inx 7391 17 Banking Banking NNP cord-010092-uftc8inx 7391 18 community community NN cord-010092-uftc8inx 7391 19 to to IN cord-010092-uftc8inx 7391 20 the the DT cord-010092-uftc8inx 7391 21 well well RB cord-010092-uftc8inx 7391 22 - - HYPH cord-010092-uftc8inx 7391 23 being being NN cord-010092-uftc8inx 7391 24 of of IN cord-010092-uftc8inx 7391 25 special special JJ cord-010092-uftc8inx 7391 26 patients patient NNS cord-010092-uftc8inx 7391 27 in in IN cord-010092-uftc8inx 7391 28 need need NN cord-010092-uftc8inx 7391 29 . . . cord-010092-uftc8inx 7392 1 This this DT cord-010092-uftc8inx 7392 2 case case NN cord-010092-uftc8inx 7392 3 illustrates illustrate VBZ cord-010092-uftc8inx 7392 4 the the DT cord-010092-uftc8inx 7392 5 response response NN cord-010092-uftc8inx 7392 6 potential potential NN cord-010092-uftc8inx 7392 7 that that WDT cord-010092-uftc8inx 7392 8 a a DT cord-010092-uftc8inx 7392 9 powerful powerful JJ cord-010092-uftc8inx 7392 10 story story NN cord-010092-uftc8inx 7392 11 and and CC cord-010092-uftc8inx 7392 12 a a DT cord-010092-uftc8inx 7392 13 medical medical JJ cord-010092-uftc8inx 7392 14 appeal appeal NN cord-010092-uftc8inx 7392 15 for for IN cord-010092-uftc8inx 7392 16 exquisitely exquisitely RB cord-010092-uftc8inx 7392 17 rare rare JJ cord-010092-uftc8inx 7392 18 blood blood NN cord-010092-uftc8inx 7392 19 utilizing utilize VBG cord-010092-uftc8inx 7392 20 social social JJ cord-010092-uftc8inx 7392 21 media medium NNS cord-010092-uftc8inx 7392 22 and and CC cord-010092-uftc8inx 7392 23 other other JJ cord-010092-uftc8inx 7392 24 online online JJ cord-010092-uftc8inx 7392 25 news news NN cord-010092-uftc8inx 7392 26 outlets outlet NNS cord-010092-uftc8inx 7392 27 can can MD cord-010092-uftc8inx 7392 28 generate generate VB cord-010092-uftc8inx 7392 29 . . . cord-010092-uftc8inx 7393 1 Background background NN cord-010092-uftc8inx 7393 2 : : : cord-010092-uftc8inx 7394 1 Blood blood NN cord-010092-uftc8inx 7394 2 platelet platelet NN cord-010092-uftc8inx 7394 3 units unit NNS cord-010092-uftc8inx 7394 4 are be VBP cord-010092-uftc8inx 7394 5 generally generally RB cord-010092-uftc8inx 7394 6 stored store VBN cord-010092-uftc8inx 7394 7 in in IN cord-010092-uftc8inx 7394 8 blood blood NN cord-010092-uftc8inx 7394 9 banks bank NNS cord-010092-uftc8inx 7394 10 for for IN cord-010092-uftc8inx 7394 11 3 3 CD cord-010092-uftc8inx 7394 12 - - SYM cord-010092-uftc8inx 7394 13 5 5 CD cord-010092-uftc8inx 7394 14 days day NNS cord-010092-uftc8inx 7394 15 , , , cord-010092-uftc8inx 7394 16 afterwards afterwards RB cord-010092-uftc8inx 7394 17 they -PRON- PRP cord-010092-uftc8inx 7394 18 are be VBP cord-010092-uftc8inx 7394 19 discarded discard VBN cord-010092-uftc8inx 7394 20 . . . cord-010092-uftc8inx 7395 1 Prepared prepare VBN cord-010092-uftc8inx 7395 2 infusible infusible JJ cord-010092-uftc8inx 7395 3 platelet platelet NN cord-010092-uftc8inx 7395 4 membrane membrane NN cord-010092-uftc8inx 7395 5 ( ( -LRB- cord-010092-uftc8inx 7395 6 IPM IPM NNP cord-010092-uftc8inx 7395 7 ) ) -RRB- cord-010092-uftc8inx 7395 8 from from IN cord-010092-uftc8inx 7395 9 fresh fresh JJ cord-010092-uftc8inx 7395 10 or or CC cord-010092-uftc8inx 7395 11 outdated outdated JJ cord-010092-uftc8inx 7395 12 human human JJ cord-010092-uftc8inx 7395 13 platelets platelet NNS cord-010092-uftc8inx 7395 14 correct correct VBP cord-010092-uftc8inx 7395 15 the the DT cord-010092-uftc8inx 7395 16 prolonged prolonged JJ cord-010092-uftc8inx 7395 17 bleeding bleeding NN cord-010092-uftc8inx 7395 18 times time NNS cord-010092-uftc8inx 7395 19 in in IN cord-010092-uftc8inx 7395 20 thrombocytopenic thrombocytopenic JJ cord-010092-uftc8inx 7395 21 animals animal NNS cord-010092-uftc8inx 7395 22 such such JJ cord-010092-uftc8inx 7395 23 as as IN cord-010092-uftc8inx 7395 24 rabbits rabbit NNS cord-010092-uftc8inx 7395 25 . . . cord-010092-uftc8inx 7396 1 Infusible infusible JJ cord-010092-uftc8inx 7396 2 platelet platelet NN cord-010092-uftc8inx 7396 3 membrane membrane NN cord-010092-uftc8inx 7396 4 ( ( -LRB- cord-010092-uftc8inx 7396 5 IPM IPM NNP cord-010092-uftc8inx 7396 6 ) ) -RRB- cord-010092-uftc8inx 7396 7 as as IN cord-010092-uftc8inx 7396 8 a a DT cord-010092-uftc8inx 7396 9 platelet platelet NN cord-010092-uftc8inx 7396 10 substitute substitute NN cord-010092-uftc8inx 7396 11 may may MD cord-010092-uftc8inx 7396 12 be be VB cord-010092-uftc8inx 7396 13 the the DT cord-010092-uftc8inx 7396 14 most most RBS cord-010092-uftc8inx 7396 15 feasible feasible JJ cord-010092-uftc8inx 7396 16 approach approach NN cord-010092-uftc8inx 7396 17 to to TO cord-010092-uftc8inx 7396 18 reach reach VB cord-010092-uftc8inx 7396 19 the the DT cord-010092-uftc8inx 7396 20 target target NN cord-010092-uftc8inx 7396 21 market market NN cord-010092-uftc8inx 7396 22 . . . cord-010092-uftc8inx 7397 1 Our -PRON- PRP$ cord-010092-uftc8inx 7397 2 previous previous JJ cord-010092-uftc8inx 7397 3 experiments experiment NNS cord-010092-uftc8inx 7397 4 have have VBP cord-010092-uftc8inx 7397 5 shown show VBN cord-010092-uftc8inx 7397 6 that that IN cord-010092-uftc8inx 7397 7 IPM IPM NNP cord-010092-uftc8inx 7397 8 has have VBZ cord-010092-uftc8inx 7397 9 a a DT cord-010092-uftc8inx 7397 10 hemostatic hemostatic JJ cord-010092-uftc8inx 7397 11 efficacy efficacy NN cord-010092-uftc8inx 7397 12 to to TO cord-010092-uftc8inx 7397 13 shorten shorten VB cord-010092-uftc8inx 7397 14 bleeding bleed VBG cord-010092-uftc8inx 7397 15 time time NN cord-010092-uftc8inx 7397 16 without without IN cord-010092-uftc8inx 7397 17 any any DT cord-010092-uftc8inx 7397 18 adverse adverse JJ cord-010092-uftc8inx 7397 19 effects effect NNS cord-010092-uftc8inx 7397 20 in in IN cord-010092-uftc8inx 7397 21 rabbits rabbit NNS cord-010092-uftc8inx 7397 22 . . . cord-010092-uftc8inx 7398 1 Aims aim VBZ cord-010092-uftc8inx 7398 2 : : : cord-010092-uftc8inx 7399 1 Abnormal abnormal JJ cord-010092-uftc8inx 7399 2 Toxicity toxicity NN cord-010092-uftc8inx 7399 3 is be VBZ cord-010092-uftc8inx 7399 4 the the DT cord-010092-uftc8inx 7399 5 European European NNP cord-010092-uftc8inx 7399 6 Pharmacopoeia Pharmacopoeia NNP cord-010092-uftc8inx 7399 7 standard standard NN cord-010092-uftc8inx 7399 8 for for IN cord-010092-uftc8inx 7399 9 assessment assessment NN cord-010092-uftc8inx 7399 10 of of IN cord-010092-uftc8inx 7399 11 biological biological JJ cord-010092-uftc8inx 7399 12 products product NNS cord-010092-uftc8inx 7399 13 which which WDT cord-010092-uftc8inx 7399 14 the the DT cord-010092-uftc8inx 7399 15 test test NN cord-010092-uftc8inx 7399 16 material material NN cord-010092-uftc8inx 7399 17 is be VBZ cord-010092-uftc8inx 7399 18 administered administer VBN cord-010092-uftc8inx 7399 19 to to IN cord-010092-uftc8inx 7399 20 the the DT cord-010092-uftc8inx 7399 21 mice mouse NNS cord-010092-uftc8inx 7399 22 . . . cord-010092-uftc8inx 7400 1 In in IN cord-010092-uftc8inx 7400 2 this this DT cord-010092-uftc8inx 7400 3 study study NN cord-010092-uftc8inx 7400 4 , , , cord-010092-uftc8inx 7400 5 abnormal abnormal JJ cord-010092-uftc8inx 7400 6 toxicity toxicity NN cord-010092-uftc8inx 7400 7 of of IN cord-010092-uftc8inx 7400 8 IPM IPM NNP cord-010092-uftc8inx 7400 9 was be VBD cord-010092-uftc8inx 7400 10 evaluated evaluate VBN cord-010092-uftc8inx 7400 11 in in IN cord-010092-uftc8inx 7400 12 experimental experimental JJ cord-010092-uftc8inx 7400 13 animal animal NN cord-010092-uftc8inx 7400 14 model model NN cord-010092-uftc8inx 7400 15 such such JJ cord-010092-uftc8inx 7400 16 as as IN cord-010092-uftc8inx 7400 17 mice mouse NNS cord-010092-uftc8inx 7400 18 to to TO cord-010092-uftc8inx 7400 19 assure assure VB cord-010092-uftc8inx 7400 20 the the DT cord-010092-uftc8inx 7400 21 safety safety NN cord-010092-uftc8inx 7400 22 of of IN cord-010092-uftc8inx 7400 23 IPM ipm NN cord-010092-uftc8inx 7400 24 without without IN cord-010092-uftc8inx 7400 25 any any DT cord-010092-uftc8inx 7400 26 evidence evidence NN cord-010092-uftc8inx 7400 27 of of IN cord-010092-uftc8inx 7400 28 serious serious JJ cord-010092-uftc8inx 7400 29 toxicity toxicity NN cord-010092-uftc8inx 7400 30 . . . cord-010092-uftc8inx 7401 1 Methods method NNS cord-010092-uftc8inx 7401 2 : : : cord-010092-uftc8inx 7401 3 In in IN cord-010092-uftc8inx 7401 4 this this DT cord-010092-uftc8inx 7401 5 experimental experimental JJ cord-010092-uftc8inx 7401 6 study study NN cord-010092-uftc8inx 7401 7 , , , cord-010092-uftc8inx 7401 8 infusible infusible JJ cord-010092-uftc8inx 7401 9 platelet platelet NN cord-010092-uftc8inx 7401 10 membrane membrane NN cord-010092-uftc8inx 7401 11 ( ( -LRB- cord-010092-uftc8inx 7401 12 IPM IPM NNP cord-010092-uftc8inx 7401 13 ) ) -RRB- cord-010092-uftc8inx 7401 14 was be VBD cord-010092-uftc8inx 7401 15 prepared prepare VBN cord-010092-uftc8inx 7401 16 from from IN cord-010092-uftc8inx 7401 17 outdated outdated JJ cord-010092-uftc8inx 7401 18 platelet platelet NN cord-010092-uftc8inx 7401 19 concentrates concentrate VBZ cord-010092-uftc8inx 7401 20 . . . cord-010092-uftc8inx 7402 1 Platelet platelet NN cord-010092-uftc8inx 7402 2 concentrates concentrate NNS cord-010092-uftc8inx 7402 3 were be VBD cord-010092-uftc8inx 7402 4 pooled pool VBN cord-010092-uftc8inx 7402 5 , , , cord-010092-uftc8inx 7402 6 disrupted disrupt VBN cord-010092-uftc8inx 7402 7 by by IN cord-010092-uftc8inx 7402 8 freeze freeze NN cord-010092-uftc8inx 7402 9 - - HYPH cord-010092-uftc8inx 7402 10 thaw thaw NN cord-010092-uftc8inx 7402 11 procedure procedure NN cord-010092-uftc8inx 7402 12 , , , cord-010092-uftc8inx 7402 13 pasteurized pasteurize VBN cord-010092-uftc8inx 7402 14 for for IN cord-010092-uftc8inx 7402 15 20 20 CD cord-010092-uftc8inx 7402 16 h h NN cord-010092-uftc8inx 7402 17 to to TO cord-010092-uftc8inx 7402 18 inactivate inactivate VB cord-010092-uftc8inx 7402 19 the the DT cord-010092-uftc8inx 7402 20 possible possible JJ cord-010092-uftc8inx 7402 21 viral viral JJ cord-010092-uftc8inx 7402 22 or or CC cord-010092-uftc8inx 7402 23 bacterial bacterial JJ cord-010092-uftc8inx 7402 24 contaminants contaminant NNS cord-010092-uftc8inx 7402 25 with with IN cord-010092-uftc8inx 7402 26 a a DT cord-010092-uftc8inx 7402 27 sodium sodium NN cord-010092-uftc8inx 7402 28 caprylate caprylate NN cord-010092-uftc8inx 7402 29 stabilizer stabilizer NN cord-010092-uftc8inx 7402 30 , , , cord-010092-uftc8inx 7402 31 formulated formulate VBN cord-010092-uftc8inx 7402 32 by by IN cord-010092-uftc8inx 7402 33 sucrose sucrose NN cord-010092-uftc8inx 7402 34 and and CC cord-010092-uftc8inx 7402 35 human human JJ cord-010092-uftc8inx 7402 36 serum serum NN cord-010092-uftc8inx 7402 37 albumin albumin NN cord-010092-uftc8inx 7402 38 and and CC cord-010092-uftc8inx 7402 39 finally finally RB cord-010092-uftc8inx 7402 40 lyophilized lyophilize VBD cord-010092-uftc8inx 7402 41 . . . cord-010092-uftc8inx 7403 1 At at IN cord-010092-uftc8inx 7403 2 first first RB cord-010092-uftc8inx 7403 3 , , , cord-010092-uftc8inx 7403 4 the the DT cord-010092-uftc8inx 7403 5 test test NN cord-010092-uftc8inx 7403 6 for for IN cord-010092-uftc8inx 7403 7 sterility sterility NN cord-010092-uftc8inx 7403 8 is be VBZ cord-010092-uftc8inx 7403 9 carried carry VBN cord-010092-uftc8inx 7403 10 out out RP cord-010092-uftc8inx 7403 11 under under IN cord-010092-uftc8inx 7403 12 aseptic aseptic JJ cord-010092-uftc8inx 7403 13 conditions condition NNS cord-010092-uftc8inx 7403 14 for for IN cord-010092-uftc8inx 7403 15 IPM ipm NN cord-010092-uftc8inx 7403 16 vials vial NNS cord-010092-uftc8inx 7403 17 and and CC cord-010092-uftc8inx 7403 18 then then RB cord-010092-uftc8inx 7403 19 we -PRON- PRP cord-010092-uftc8inx 7403 20 injected inject VBD cord-010092-uftc8inx 7403 21 0.5 0.5 CD cord-010092-uftc8inx 7403 22 ml ml NNS cord-010092-uftc8inx 7403 23 of of IN cord-010092-uftc8inx 7403 24 IPM IPM NNP cord-010092-uftc8inx 7403 25 ( ( -LRB- cord-010092-uftc8inx 7403 26 2 2 CD cord-010092-uftc8inx 7403 27 mg mg NNP cord-010092-uftc8inx 7403 28 / / SYM cord-010092-uftc8inx 7403 29 kg kg NNP cord-010092-uftc8inx 7403 30 ) ) -RRB- cord-010092-uftc8inx 7403 31 intravenously intravenously RB cord-010092-uftc8inx 7403 32 between between IN cord-010092-uftc8inx 7403 33 15 15 CD cord-010092-uftc8inx 7403 34 to to TO cord-010092-uftc8inx 7403 35 30 30 CD cord-010092-uftc8inx 7403 36 seconds second NNS cord-010092-uftc8inx 7403 37 into into IN cord-010092-uftc8inx 7403 38 each each DT cord-010092-uftc8inx 7403 39 5 5 CD cord-010092-uftc8inx 7403 40 health health NN cord-010092-uftc8inx 7403 41 mice mouse NNS cord-010092-uftc8inx 7403 42 , , , cord-010092-uftc8inx 7403 43 weighing weigh VBG cord-010092-uftc8inx 7403 44 17 17 CD cord-010092-uftc8inx 7403 45 - - SYM cord-010092-uftc8inx 7403 46 22 22 CD cord-010092-uftc8inx 7403 47 grams gram NNS cord-010092-uftc8inx 7403 48 . . . cord-010092-uftc8inx 7404 1 These these DT cord-010092-uftc8inx 7404 2 tests test NNS cord-010092-uftc8inx 7404 3 were be VBD cord-010092-uftc8inx 7404 4 performed perform VBN cord-010092-uftc8inx 7404 5 according accord VBG cord-010092-uftc8inx 7404 6 to to IN cord-010092-uftc8inx 7404 7 EU EU NNP cord-010092-uftc8inx 7404 8 pharmacopeia pharmacopeia NN cord-010092-uftc8inx 7404 9 monographs monographs NN cord-010092-uftc8inx 7404 10 . . . cord-010092-uftc8inx 7405 1 Results result NNS cord-010092-uftc8inx 7405 2 : : : cord-010092-uftc8inx 7406 1 In in IN cord-010092-uftc8inx 7406 2 the the DT cord-010092-uftc8inx 7406 3 sterility sterility NN cord-010092-uftc8inx 7406 4 test test NN cord-010092-uftc8inx 7406 5 no no DT cord-010092-uftc8inx 7406 6 evidence evidence NN cord-010092-uftc8inx 7406 7 of of IN cord-010092-uftc8inx 7406 8 microbial microbial JJ cord-010092-uftc8inx 7406 9 growth growth NN cord-010092-uftc8inx 7406 10 in in IN cord-010092-uftc8inx 7406 11 our -PRON- PRP$ cord-010092-uftc8inx 7406 12 product product NN cord-010092-uftc8inx 7406 13 is be VBZ cord-010092-uftc8inx 7406 14 found find VBN cord-010092-uftc8inx 7406 15 . . . cord-010092-uftc8inx 7407 1 The the DT cord-010092-uftc8inx 7407 2 abnormal abnormal JJ cord-010092-uftc8inx 7407 3 toxicity toxicity NN cord-010092-uftc8inx 7407 4 test test NN cord-010092-uftc8inx 7407 5 will will MD cord-010092-uftc8inx 7407 6 be be VB cord-010092-uftc8inx 7407 7 passed pass VBN cord-010092-uftc8inx 7407 8 if if IN cord-010092-uftc8inx 7407 9 none none NN cord-010092-uftc8inx 7407 10 of of IN cord-010092-uftc8inx 7407 11 animals animal NNS cord-010092-uftc8inx 7407 12 die die VBP cord-010092-uftc8inx 7407 13 during during IN cord-010092-uftc8inx 7407 14 24 24 CD cord-010092-uftc8inx 7407 15 h h NN cord-010092-uftc8inx 7407 16 after after IN cord-010092-uftc8inx 7407 17 injection injection NN cord-010092-uftc8inx 7407 18 . . . cord-010092-uftc8inx 7408 1 If if IN cord-010092-uftc8inx 7408 2 more more JJR cord-010092-uftc8inx 7408 3 than than IN cord-010092-uftc8inx 7408 4 one one CD cord-010092-uftc8inx 7408 5 animal animal NN cord-010092-uftc8inx 7408 6 dies die VBZ cord-010092-uftc8inx 7408 7 , , , cord-010092-uftc8inx 7408 8 the the DT cord-010092-uftc8inx 7408 9 preparation preparation NN cord-010092-uftc8inx 7408 10 fails fail VBZ cord-010092-uftc8inx 7408 11 the the DT cord-010092-uftc8inx 7408 12 test test NN cord-010092-uftc8inx 7408 13 . . . cord-010092-uftc8inx 7409 1 If if IN cord-010092-uftc8inx 7409 2 one one CD cord-010092-uftc8inx 7409 3 of of IN cord-010092-uftc8inx 7409 4 the the DT cord-010092-uftc8inx 7409 5 animals animal NNS cord-010092-uftc8inx 7409 6 just just RB cord-010092-uftc8inx 7409 7 dies die VBZ cord-010092-uftc8inx 7409 8 , , , cord-010092-uftc8inx 7409 9 the the DT cord-010092-uftc8inx 7409 10 test test NN cord-010092-uftc8inx 7409 11 is be VBZ cord-010092-uftc8inx 7409 12 repeated repeat VBN cord-010092-uftc8inx 7409 13 . . . cord-010092-uftc8inx 7410 1 In in IN cord-010092-uftc8inx 7410 2 our -PRON- PRP$ cord-010092-uftc8inx 7410 3 experiment experiment NN cord-010092-uftc8inx 7410 4 all all DT cord-010092-uftc8inx 7410 5 five five CD cord-010092-uftc8inx 7410 6 mice mouse NNS cord-010092-uftc8inx 7410 7 were be VBD cord-010092-uftc8inx 7410 8 alive alive JJ cord-010092-uftc8inx 7410 9 after after IN cord-010092-uftc8inx 7410 10 24 24 CD cord-010092-uftc8inx 7410 11 h h NN cord-010092-uftc8inx 7410 12 of of IN cord-010092-uftc8inx 7410 13 IPM IPM NNP cord-010092-uftc8inx 7410 14 injection injection NN cord-010092-uftc8inx 7410 15 . . . cord-010092-uftc8inx 7411 1 Summary Summary NNP cord-010092-uftc8inx 7411 2 / / SYM cord-010092-uftc8inx 7411 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 7411 4 : : : cord-010092-uftc8inx 7412 1 In in IN cord-010092-uftc8inx 7412 2 this this DT cord-010092-uftc8inx 7412 3 research research NN cord-010092-uftc8inx 7412 4 the the DT cord-010092-uftc8inx 7412 5 results result NNS cord-010092-uftc8inx 7412 6 showed show VBD cord-010092-uftc8inx 7412 7 that that IN cord-010092-uftc8inx 7412 8 IPM IPM NNP cord-010092-uftc8inx 7412 9 as as IN cord-010092-uftc8inx 7412 10 a a DT cord-010092-uftc8inx 7412 11 platelet platelet NN cord-010092-uftc8inx 7412 12 substitute substitute NN cord-010092-uftc8inx 7412 13 is be VBZ cord-010092-uftc8inx 7412 14 free free JJ cord-010092-uftc8inx 7412 15 of of IN cord-010092-uftc8inx 7412 16 abnormal abnormal JJ cord-010092-uftc8inx 7412 17 toxicity toxicity NN cord-010092-uftc8inx 7412 18 with with IN cord-010092-uftc8inx 7412 19 adequate adequate JJ cord-010092-uftc8inx 7412 20 safety safety NN cord-010092-uftc8inx 7412 21 and and CC cord-010092-uftc8inx 7412 22 it -PRON- PRP cord-010092-uftc8inx 7412 23 may may MD cord-010092-uftc8inx 7412 24 be be VB cord-010092-uftc8inx 7412 25 used use VBN cord-010092-uftc8inx 7412 26 in in IN cord-010092-uftc8inx 7412 27 human human JJ cord-010092-uftc8inx 7412 28 clinical clinical JJ cord-010092-uftc8inx 7412 29 trial trial NN cord-010092-uftc8inx 7412 30 studies study NNS cord-010092-uftc8inx 7412 31 as as IN cord-010092-uftc8inx 7412 32 a a DT cord-010092-uftc8inx 7412 33 feasible feasible JJ cord-010092-uftc8inx 7412 34 approach approach NN cord-010092-uftc8inx 7412 35 to to TO cord-010092-uftc8inx 7412 36 develop develop VB cord-010092-uftc8inx 7412 37 a a DT cord-010092-uftc8inx 7412 38 platelet platelet NN cord-010092-uftc8inx 7412 39 substitute substitute NN cord-010092-uftc8inx 7412 40 in in IN cord-010092-uftc8inx 7412 41 the the DT cord-010092-uftc8inx 7412 42 future future NN cord-010092-uftc8inx 7412 43 . . . cord-010092-uftc8inx 7413 1 However however RB cord-010092-uftc8inx 7413 2 , , , cord-010092-uftc8inx 7413 3 further further JJ cord-010092-uftc8inx 7413 4 studies study NNS cord-010092-uftc8inx 7413 5 are be VBP cord-010092-uftc8inx 7413 6 required require VBN cord-010092-uftc8inx 7413 7 to to TO cord-010092-uftc8inx 7413 8 confirm confirm VB cord-010092-uftc8inx 7413 9 the the DT cord-010092-uftc8inx 7413 10 different different JJ cord-010092-uftc8inx 7413 11 aspects aspect NNS cord-010092-uftc8inx 7413 12 of of IN cord-010092-uftc8inx 7413 13 its -PRON- PRP$ cord-010092-uftc8inx 7413 14 safety safety NN cord-010092-uftc8inx 7413 15 as as RB cord-010092-uftc8inx 7413 16 well well RB cord-010092-uftc8inx 7413 17 . . . cord-010092-uftc8inx 7414 1 The the DT cord-010092-uftc8inx 7414 2 success success NN cord-010092-uftc8inx 7414 3 of of IN cord-010092-uftc8inx 7414 4 such such JJ cord-010092-uftc8inx 7414 5 investigations investigation NNS cord-010092-uftc8inx 7414 6 may may MD cord-010092-uftc8inx 7414 7 affect affect VB cord-010092-uftc8inx 7414 8 patients patient NNS cord-010092-uftc8inx 7414 9 ' ' POS cord-010092-uftc8inx 7414 10 care care NN cord-010092-uftc8inx 7414 11 in in IN cord-010092-uftc8inx 7414 12 transfusion transfusion NN cord-010092-uftc8inx 7414 13 medicine medicine NN cord-010092-uftc8inx 7414 14 in in IN cord-010092-uftc8inx 7414 15 the the DT cord-010092-uftc8inx 7414 16 future future NN cord-010092-uftc8inx 7414 17 . . . cord-010092-uftc8inx 7415 1 A a DT cord-010092-uftc8inx 7415 2 substantial substantial JJ cord-010092-uftc8inx 7415 3 number number NN cord-010092-uftc8inx 7415 4 of of IN cord-010092-uftc8inx 7415 5 infants infant NNS cord-010092-uftc8inx 7415 6 , , , cord-010092-uftc8inx 7415 7 especially especially RB cord-010092-uftc8inx 7415 8 premature premature JJ cord-010092-uftc8inx 7415 9 infants infant NNS cord-010092-uftc8inx 7415 10 , , , cord-010092-uftc8inx 7415 11 are be VBP cord-010092-uftc8inx 7415 12 unable unable JJ cord-010092-uftc8inx 7415 13 to to TO cord-010092-uftc8inx 7415 14 receive receive VB cord-010092-uftc8inx 7415 15 adequate adequate JJ cord-010092-uftc8inx 7415 16 amounts amount NNS cord-010092-uftc8inx 7415 17 of of IN cord-010092-uftc8inx 7415 18 their -PRON- PRP$ cord-010092-uftc8inx 7415 19 mothers mother NNS cord-010092-uftc8inx 7415 20 ' ' POS cord-010092-uftc8inx 7415 21 milk milk NN cord-010092-uftc8inx 7415 22 for for IN cord-010092-uftc8inx 7415 23 a a DT cord-010092-uftc8inx 7415 24 variety variety NN cord-010092-uftc8inx 7415 25 of of IN cord-010092-uftc8inx 7415 26 reasons reason NNS cord-010092-uftc8inx 7415 27 . . . cord-010092-uftc8inx 7416 1 The the DT cord-010092-uftc8inx 7416 2 World World NNP cord-010092-uftc8inx 7416 3 Health Health NNP cord-010092-uftc8inx 7416 4 Organization Organization NNP cord-010092-uftc8inx 7416 5 recommends recommend VBZ cord-010092-uftc8inx 7416 6 that that IN cord-010092-uftc8inx 7416 7 infants infant NNS cord-010092-uftc8inx 7416 8 , , , cord-010092-uftc8inx 7416 9 especially especially RB cord-010092-uftc8inx 7416 10 preterm preterm NNS cord-010092-uftc8inx 7416 11 and and CC cord-010092-uftc8inx 7416 12 ill ill JJ cord-010092-uftc8inx 7416 13 infants infant NNS cord-010092-uftc8inx 7416 14 are be VBP cord-010092-uftc8inx 7416 15 fed feed VBN cord-010092-uftc8inx 7416 16 with with IN cord-010092-uftc8inx 7416 17 quality quality NN cord-010092-uftc8inx 7416 18 - - HYPH cord-010092-uftc8inx 7416 19 controlled control VBN cord-010092-uftc8inx 7416 20 donor donor NN cord-010092-uftc8inx 7416 21 milk milk NN cord-010092-uftc8inx 7416 22 if if IN cord-010092-uftc8inx 7416 23 they -PRON- PRP cord-010092-uftc8inx 7416 24 can can MD cord-010092-uftc8inx 7416 25 not not RB cord-010092-uftc8inx 7416 26 be be VB cord-010092-uftc8inx 7416 27 fed feed VBN cord-010092-uftc8inx 7416 28 with with IN cord-010092-uftc8inx 7416 29 their -PRON- PRP$ cord-010092-uftc8inx 7416 30 own own JJ cord-010092-uftc8inx 7416 31 mother mother NN cord-010092-uftc8inx 7416 32 0 0 CD cord-010092-uftc8inx 7416 33 s s NN cord-010092-uftc8inx 7416 34 milk milk NN cord-010092-uftc8inx 7416 35 . . . cord-010092-uftc8inx 7417 1 Due due IN cord-010092-uftc8inx 7417 2 to to IN cord-010092-uftc8inx 7417 3 the the DT cord-010092-uftc8inx 7417 4 possible possible JJ cord-010092-uftc8inx 7417 5 transmission transmission NN cord-010092-uftc8inx 7417 6 of of IN cord-010092-uftc8inx 7417 7 the the DT cord-010092-uftc8inx 7417 8 Human Human NNP cord-010092-uftc8inx 7417 9 Immunodeficiency Immunodeficiency NNP cord-010092-uftc8inx 7417 10 Virus Virus NNP cord-010092-uftc8inx 7417 11 many many JJ cord-010092-uftc8inx 7417 12 human human JJ cord-010092-uftc8inx 7417 13 milk milk NN cord-010092-uftc8inx 7417 14 banks bank NNS cord-010092-uftc8inx 7417 15 closed close VBD cord-010092-uftc8inx 7417 16 in in IN cord-010092-uftc8inx 7417 17 the the DT cord-010092-uftc8inx 7417 18 1980s 1980 NNS cord-010092-uftc8inx 7417 19 , , , cord-010092-uftc8inx 7417 20 therefore therefore RB cord-010092-uftc8inx 7417 21 the the DT cord-010092-uftc8inx 7417 22 availability availability NN cord-010092-uftc8inx 7417 23 of of IN cord-010092-uftc8inx 7417 24 donor donor NN cord-010092-uftc8inx 7417 25 milk milk NN cord-010092-uftc8inx 7417 26 has have VBZ cord-010092-uftc8inx 7417 27 decreased decrease VBN cord-010092-uftc8inx 7417 28 . . . cord-010092-uftc8inx 7418 1 Aims aim VBZ cord-010092-uftc8inx 7418 2 : : : cord-010092-uftc8inx 7419 1 We -PRON- PRP cord-010092-uftc8inx 7419 2 analyzed analyze VBD cord-010092-uftc8inx 7419 3 the the DT cord-010092-uftc8inx 7419 4 processing processing NN cord-010092-uftc8inx 7419 5 of of IN cord-010092-uftc8inx 7419 6 donor donor NN cord-010092-uftc8inx 7419 7 milk milk NN cord-010092-uftc8inx 7419 8 and and CC cord-010092-uftc8inx 7419 9 the the DT cord-010092-uftc8inx 7419 10 required require VBN cord-010092-uftc8inx 7419 11 laboratory laboratory NN cord-010092-uftc8inx 7419 12 tests test NNS cord-010092-uftc8inx 7419 13 to to TO cord-010092-uftc8inx 7419 14 establish establish VB cord-010092-uftc8inx 7419 15 a a DT cord-010092-uftc8inx 7419 16 human human JJ cord-010092-uftc8inx 7419 17 milk milk NN cord-010092-uftc8inx 7419 18 bank bank NN cord-010092-uftc8inx 7419 19 within within IN cord-010092-uftc8inx 7419 20 our -PRON- PRP$ cord-010092-uftc8inx 7419 21 blood blood NN cord-010092-uftc8inx 7419 22 donation donation NN cord-010092-uftc8inx 7419 23 service service NN cord-010092-uftc8inx 7419 24 in in IN cord-010092-uftc8inx 7419 25 cooperation cooperation NN cord-010092-uftc8inx 7419 26 with with IN cord-010092-uftc8inx 7419 27 the the DT cord-010092-uftc8inx 7419 28 department department NN cord-010092-uftc8inx 7419 29 of of IN cord-010092-uftc8inx 7419 30 neonatology neonatology NN cord-010092-uftc8inx 7419 31 at at IN cord-010092-uftc8inx 7419 32 the the DT cord-010092-uftc8inx 7419 33 Frankfurt Frankfurt NNP cord-010092-uftc8inx 7419 34 University University NNP cord-010092-uftc8inx 7419 35 Hospital Hospital NNP cord-010092-uftc8inx 7419 36 . . . cord-010092-uftc8inx 7420 1 Methods method NNS cord-010092-uftc8inx 7420 2 : : : cord-010092-uftc8inx 7421 1 Based base VBN cord-010092-uftc8inx 7421 2 on on IN cord-010092-uftc8inx 7421 3 the the DT cord-010092-uftc8inx 7421 4 Recommendations Recommendations NNPS cord-010092-uftc8inx 7421 5 for for IN cord-010092-uftc8inx 7421 6 promoting promote VBG cord-010092-uftc8inx 7421 7 human human JJ cord-010092-uftc8inx 7421 8 milk milk NN cord-010092-uftc8inx 7421 9 banks bank NNS cord-010092-uftc8inx 7421 10 in in IN cord-010092-uftc8inx 7421 11 Germany Germany NNP cord-010092-uftc8inx 7421 12 , , , cord-010092-uftc8inx 7421 13 Austria Austria NNP cord-010092-uftc8inx 7421 14 , , , cord-010092-uftc8inx 7421 15 and and CC cord-010092-uftc8inx 7421 16 Switzerland Switzerland NNP cord-010092-uftc8inx 7421 17 ( ( -LRB- cord-010092-uftc8inx 7421 18 EFCNI EFCNI NNP cord-010092-uftc8inx 7421 19 ) ) -RRB- cord-010092-uftc8inx 7422 1 we -PRON- PRP cord-010092-uftc8inx 7422 2 evaluated evaluate VBD cord-010092-uftc8inx 7422 3 the the DT cord-010092-uftc8inx 7422 4 manufacturing manufacturing NN cord-010092-uftc8inx 7422 5 steps step NNS cord-010092-uftc8inx 7422 6 and and CC cord-010092-uftc8inx 7422 7 the the DT cord-010092-uftc8inx 7422 8 quality quality NN cord-010092-uftc8inx 7422 9 controls control NNS cord-010092-uftc8inx 7422 10 require require VBP cord-010092-uftc8inx 7422 11 to to TO cord-010092-uftc8inx 7422 12 establish establish VB cord-010092-uftc8inx 7422 13 a a DT cord-010092-uftc8inx 7422 14 human human JJ cord-010092-uftc8inx 7422 15 milk milk NN cord-010092-uftc8inx 7422 16 bank bank NN cord-010092-uftc8inx 7422 17 . . . cord-010092-uftc8inx 7423 1 Background background NN cord-010092-uftc8inx 7423 2 : : : cord-010092-uftc8inx 7424 1 For for IN cord-010092-uftc8inx 7424 2 patients patient NNS cord-010092-uftc8inx 7424 3 suffering suffer VBG cord-010092-uftc8inx 7424 4 from from IN cord-010092-uftc8inx 7424 5 severe severe JJ cord-010092-uftc8inx 7424 6 ocular ocular JJ cord-010092-uftc8inx 7424 7 surface surface NN cord-010092-uftc8inx 7424 8 disorders disorder NNS cord-010092-uftc8inx 7424 9 treatment treatment NN cord-010092-uftc8inx 7424 10 with with IN cord-010092-uftc8inx 7424 11 blood blood NN cord-010092-uftc8inx 7424 12 derived derive VBN cord-010092-uftc8inx 7424 13 serum serum NN cord-010092-uftc8inx 7424 14 eye eye NN cord-010092-uftc8inx 7424 15 drops drop NNS cord-010092-uftc8inx 7424 16 ( ( -LRB- cord-010092-uftc8inx 7424 17 SED SED NNP cord-010092-uftc8inx 7424 18 ) ) -RRB- cord-010092-uftc8inx 7424 19 is be VBZ cord-010092-uftc8inx 7424 20 a a DT cord-010092-uftc8inx 7424 21 highly highly RB cord-010092-uftc8inx 7424 22 effective effective JJ cord-010092-uftc8inx 7424 23 therapy therapy NN cord-010092-uftc8inx 7424 24 . . . cord-010092-uftc8inx 7425 1 Autologous autologous JJ cord-010092-uftc8inx 7425 2 SED SED NNP cord-010092-uftc8inx 7425 3 , , , cord-010092-uftc8inx 7425 4 prepared prepare VBN cord-010092-uftc8inx 7425 5 from from IN cord-010092-uftc8inx 7425 6 the the DT cord-010092-uftc8inx 7425 7 patient patient NN cord-010092-uftc8inx 7425 8 's 's POS cord-010092-uftc8inx 7425 9 own own JJ cord-010092-uftc8inx 7425 10 blood blood NN cord-010092-uftc8inx 7425 11 , , , cord-010092-uftc8inx 7425 12 is be VBZ cord-010092-uftc8inx 7425 13 used use VBN cord-010092-uftc8inx 7425 14 preferably preferably RB cord-010092-uftc8inx 7425 15 . . . cord-010092-uftc8inx 7426 1 For for IN cord-010092-uftc8inx 7426 2 this this DT cord-010092-uftc8inx 7426 3 approach approach NN cord-010092-uftc8inx 7426 4 we -PRON- PRP cord-010092-uftc8inx 7426 5 have have VBP cord-010092-uftc8inx 7426 6 more more JJR cord-010092-uftc8inx 7426 7 than than IN cord-010092-uftc8inx 7426 8 6 6 CD cord-010092-uftc8inx 7426 9 years year NNS cord-010092-uftc8inx 7426 10 of of IN cord-010092-uftc8inx 7426 11 experience experience NN cord-010092-uftc8inx 7426 12 . . . cord-010092-uftc8inx 7427 1 If if IN cord-010092-uftc8inx 7427 2 Auto auto NN cord-010092-uftc8inx 7427 3 - - HYPH cord-010092-uftc8inx 7427 4 SED SED NNP cord-010092-uftc8inx 7427 5 can can MD cord-010092-uftc8inx 7427 6 not not RB cord-010092-uftc8inx 7427 7 be be VB cord-010092-uftc8inx 7427 8 manufactured manufacture VBN cord-010092-uftc8inx 7427 9 due due IN cord-010092-uftc8inx 7427 10 to to IN cord-010092-uftc8inx 7427 11 medical medical JJ cord-010092-uftc8inx 7427 12 reasons reason NNS cord-010092-uftc8inx 7427 13 allogeneic allogeneic IN cord-010092-uftc8inx 7427 14 SED sed NN cord-010092-uftc8inx 7427 15 present present VBP cord-010092-uftc8inx 7427 16 an an DT cord-010092-uftc8inx 7427 17 alternative alternative NN cord-010092-uftc8inx 7427 18 . . . cord-010092-uftc8inx 7428 1 Since since IN cord-010092-uftc8inx 7428 2 2 2 CD cord-010092-uftc8inx 7428 3 years year NNS cord-010092-uftc8inx 7428 4 , , , cord-010092-uftc8inx 7428 5 the the DT cord-010092-uftc8inx 7428 6 allogeneic allogeneic NN cord-010092-uftc8inx 7428 7 approach approach NN cord-010092-uftc8inx 7428 8 is be VBZ cord-010092-uftc8inx 7428 9 well well RB cord-010092-uftc8inx 7428 10 established establish VBN cord-010092-uftc8inx 7428 11 in in IN cord-010092-uftc8inx 7428 12 our -PRON- PRP$ cord-010092-uftc8inx 7428 13 center center NN cord-010092-uftc8inx 7428 14 . . . cord-010092-uftc8inx 7429 1 Aims aim VBZ cord-010092-uftc8inx 7429 2 : : : cord-010092-uftc8inx 7430 1 Retrospectively retrospectively RB cord-010092-uftc8inx 7430 2 evaluation evaluation NN cord-010092-uftc8inx 7430 3 of of IN cord-010092-uftc8inx 7430 4 our -PRON- PRP$ cord-010092-uftc8inx 7430 5 experience experience NN cord-010092-uftc8inx 7430 6 with with IN cord-010092-uftc8inx 7430 7 Allo allo NN cord-010092-uftc8inx 7430 8 - - HYPH cord-010092-uftc8inx 7430 9 SED sed NN cord-010092-uftc8inx 7430 10 . . . cord-010092-uftc8inx 7431 1 Methods method NNS cord-010092-uftc8inx 7431 2 : : : cord-010092-uftc8inx 7432 1 In in IN cord-010092-uftc8inx 7432 2 Germany Germany NNP cord-010092-uftc8inx 7432 3 manufacturing manufacturing NN cord-010092-uftc8inx 7432 4 of of IN cord-010092-uftc8inx 7432 5 Allo Allo NNP cord-010092-uftc8inx 7432 6 - - HYPH cord-010092-uftc8inx 7432 7 SED SED NNP cord-010092-uftc8inx 7432 8 is be VBZ cord-010092-uftc8inx 7432 9 only only RB cord-010092-uftc8inx 7432 10 possible possible JJ cord-010092-uftc8inx 7432 11 as as IN cord-010092-uftc8inx 7432 12 an an DT cord-010092-uftc8inx 7432 13 " " `` cord-010092-uftc8inx 7432 14 individual individual JJ cord-010092-uftc8inx 7432 15 healing healing NN cord-010092-uftc8inx 7432 16 attempt attempt NN cord-010092-uftc8inx 7432 17 " " '' cord-010092-uftc8inx 7432 18 . . . cord-010092-uftc8inx 7433 1 For for IN cord-010092-uftc8inx 7433 2 each each DT cord-010092-uftc8inx 7433 3 patient patient NN cord-010092-uftc8inx 7433 4 experienced experience VBD cord-010092-uftc8inx 7433 5 regular regular JJ cord-010092-uftc8inx 7433 6 AB0-identical ab0-identical JJ cord-010092-uftc8inx 7433 7 male male JJ cord-010092-uftc8inx 7433 8 donors donor NNS cord-010092-uftc8inx 7433 9 without without IN cord-010092-uftc8inx 7433 10 blood blood NN cord-010092-uftc8inx 7433 11 borne bear VBN cord-010092-uftc8inx 7433 12 disease disease NN cord-010092-uftc8inx 7433 13 , , , cord-010092-uftc8inx 7433 14 who who WP cord-010092-uftc8inx 7433 15 never never RB cord-010092-uftc8inx 7433 16 received receive VBD cord-010092-uftc8inx 7433 17 blood blood NN cord-010092-uftc8inx 7433 18 products product NNS cord-010092-uftc8inx 7433 19 and and CC cord-010092-uftc8inx 7433 20 not not RB cord-010092-uftc8inx 7433 21 taking take VBG cord-010092-uftc8inx 7433 22 any any DT cord-010092-uftc8inx 7433 23 kind kind NN cord-010092-uftc8inx 7433 24 of of IN cord-010092-uftc8inx 7433 25 medication medication NN cord-010092-uftc8inx 7433 26 are be VBP cord-010092-uftc8inx 7433 27 selected select VBN cord-010092-uftc8inx 7433 28 . . . cord-010092-uftc8inx 7434 1 Additionally additionally RB cord-010092-uftc8inx 7434 2 , , , cord-010092-uftc8inx 7434 3 donors donor NNS cord-010092-uftc8inx 7434 4 must must MD cord-010092-uftc8inx 7434 5 pass pass VB cord-010092-uftc8inx 7434 6 a a DT cord-010092-uftc8inx 7434 7 questionnaire questionnaire NN cord-010092-uftc8inx 7434 8 excluding exclude VBG cord-010092-uftc8inx 7434 9 any any DT cord-010092-uftc8inx 7434 10 form form NN cord-010092-uftc8inx 7434 11 of of IN cord-010092-uftc8inx 7434 12 dry dry JJ cord-010092-uftc8inx 7434 13 eye eye NN cord-010092-uftc8inx 7434 14 syndrome syndrome NN cord-010092-uftc8inx 7434 15 . . . cord-010092-uftc8inx 7435 1 Allo Allo NNP cord-010092-uftc8inx 7435 2 - - HYPH cord-010092-uftc8inx 7435 3 SED SED NNP cord-010092-uftc8inx 7435 4 are be VBP cord-010092-uftc8inx 7435 5 manufactured manufacture VBN cord-010092-uftc8inx 7435 6 directed direct VBN cord-010092-uftc8inx 7435 7 for for IN cord-010092-uftc8inx 7435 8 each each DT cord-010092-uftc8inx 7435 9 individual individual JJ cord-010092-uftc8inx 7435 10 patient patient NN cord-010092-uftc8inx 7435 11 according accord VBG cord-010092-uftc8inx 7435 12 to to IN cord-010092-uftc8inx 7435 13 the the DT cord-010092-uftc8inx 7435 14 process process NN cord-010092-uftc8inx 7435 15 for for IN cord-010092-uftc8inx 7435 16 Auto Auto NNP cord-010092-uftc8inx 7435 17 - - HYPH cord-010092-uftc8inx 7435 18 SED SED NNP cord-010092-uftc8inx 7435 19 in in IN cord-010092-uftc8inx 7435 20 a a DT cord-010092-uftc8inx 7435 21 closed closed JJ cord-010092-uftc8inx 7435 22 system system NN cord-010092-uftc8inx 7435 23 . . . cord-010092-uftc8inx 7436 1 Patient patient JJ cord-010092-uftc8inx 7436 2 files file NNS cord-010092-uftc8inx 7436 3 of of IN cord-010092-uftc8inx 7436 4 our -PRON- PRP$ cord-010092-uftc8inx 7436 5 serum serum NN cord-010092-uftc8inx 7436 6 eye eye NN cord-010092-uftc8inx 7436 7 drops drop VBZ cord-010092-uftc8inx 7436 8 donors donor NNS cord-010092-uftc8inx 7436 9 were be VBD cord-010092-uftc8inx 7436 10 screened screen VBN cord-010092-uftc8inx 7436 11 for for IN cord-010092-uftc8inx 7436 12 patients patient NNS cord-010092-uftc8inx 7436 13 receiving receive VBG cord-010092-uftc8inx 7436 14 an an DT cord-010092-uftc8inx 7436 15 allogeneic allogeneic NN cord-010092-uftc8inx 7436 16 treatment treatment NN cord-010092-uftc8inx 7436 17 . . . cord-010092-uftc8inx 7437 1 Data datum NNS cord-010092-uftc8inx 7437 2 concerning concern VBG cord-010092-uftc8inx 7437 3 indication indication NN cord-010092-uftc8inx 7437 4 for for IN cord-010092-uftc8inx 7437 5 Allo Allo NNP cord-010092-uftc8inx 7437 6 - - HYPH cord-010092-uftc8inx 7437 7 SED sed NN cord-010092-uftc8inx 7437 8 , , , cord-010092-uftc8inx 7437 9 contraindication contraindication NN cord-010092-uftc8inx 7437 10 for for IN cord-010092-uftc8inx 7437 11 phlebotomy phlebotomy NN cord-010092-uftc8inx 7437 12 , , , cord-010092-uftc8inx 7437 13 problems problem NNS cord-010092-uftc8inx 7437 14 with with IN cord-010092-uftc8inx 7437 15 donor donor NN cord-010092-uftc8inx 7437 16 selection selection NN cord-010092-uftc8inx 7437 17 and and CC cord-010092-uftc8inx 7437 18 manufacturing manufacturing NN cord-010092-uftc8inx 7437 19 , , , cord-010092-uftc8inx 7437 20 as as RB cord-010092-uftc8inx 7437 21 well well RB cord-010092-uftc8inx 7437 22 as as IN cord-010092-uftc8inx 7437 23 serological serological JJ cord-010092-uftc8inx 7437 24 and and CC cord-010092-uftc8inx 7437 25 microbiological microbiological JJ cord-010092-uftc8inx 7437 26 testing testing NN cord-010092-uftc8inx 7437 27 results result NNS cord-010092-uftc8inx 7437 28 were be VBD cord-010092-uftc8inx 7437 29 obtained obtain VBN cord-010092-uftc8inx 7437 30 . . . cord-010092-uftc8inx 7438 1 Clinical clinical JJ cord-010092-uftc8inx 7438 2 results result NNS cord-010092-uftc8inx 7438 3 were be VBD cord-010092-uftc8inx 7438 4 evaluated evaluate VBN cord-010092-uftc8inx 7438 5 © © NN cord-010092-uftc8inx 7438 6 2019 2019 CD cord-010092-uftc8inx 7439 1 The the DT cord-010092-uftc8inx 7439 2 Authors author NNS cord-010092-uftc8inx 7439 3 Vox Vox NNP cord-010092-uftc8inx 7439 4 Sanguinis Sanguinis NNP cord-010092-uftc8inx 7439 5 © © NN cord-010092-uftc8inx 7440 1 2019 2019 CD cord-010092-uftc8inx 7440 2 International International NNP cord-010092-uftc8inx 7440 3 Society Society NNP cord-010092-uftc8inx 7440 4 of of IN cord-010092-uftc8inx 7440 5 Blood Blood NNP cord-010092-uftc8inx 7440 6 Transfusion Transfusion NNP cord-010092-uftc8inx 7440 7 Vox Vox NNP cord-010092-uftc8inx 7440 8 Sanguinis Sanguinis NNP cord-010092-uftc8inx 7440 9 ( ( -LRB- cord-010092-uftc8inx 7440 10 2019 2019 CD cord-010092-uftc8inx 7440 11 ) ) -RRB- cord-010092-uftc8inx 7440 12 114 114 CD cord-010092-uftc8inx 7441 1 ( ( -LRB- cord-010092-uftc8inx 7441 2 Suppl Suppl NNP cord-010092-uftc8inx 7441 3 . . NNP cord-010092-uftc8inx 7441 4 1 1 CD cord-010092-uftc8inx 7441 5 ) ) -RRB- cord-010092-uftc8inx 7441 6 , , , cord-010092-uftc8inx 7441 7 5 5 CD cord-010092-uftc8inx 7441 8 - - SYM cord-010092-uftc8inx 7441 9 240 240 CD cord-010092-uftc8inx 7441 10 by by IN cord-010092-uftc8inx 7441 11 ocular ocular JJ cord-010092-uftc8inx 7441 12 surface surface NN cord-010092-uftc8inx 7441 13 disease disease NN cord-010092-uftc8inx 7441 14 index index NN cord-010092-uftc8inx 7441 15 ( ( -LRB- cord-010092-uftc8inx 7441 16 OSDI OSDI NNP cord-010092-uftc8inx 7441 17 ) ) -RRB- cord-010092-uftc8inx 7441 18 and and CC cord-010092-uftc8inx 7441 19 patient patient NNP cord-010092-uftc8inx 7441 20 's 's POS cord-010092-uftc8inx 7441 21 questionnaire questionnaire NN cord-010092-uftc8inx 7441 22 , , , cord-010092-uftc8inx 7441 23 asking ask VBG cord-010092-uftc8inx 7441 24 for for IN cord-010092-uftc8inx 7441 25 subjective subjective JJ cord-010092-uftc8inx 7441 26 benefit benefit NN cord-010092-uftc8inx 7441 27 , , , cord-010092-uftc8inx 7441 28 symptom symptom NN cord-010092-uftc8inx 7441 29 reduction reduction NN cord-010092-uftc8inx 7441 30 , , , cord-010092-uftc8inx 7441 31 possible possible JJ cord-010092-uftc8inx 7441 32 side side NN cord-010092-uftc8inx 7441 33 effects effect NNS cord-010092-uftc8inx 7441 34 , , , cord-010092-uftc8inx 7441 35 consumption consumption NN cord-010092-uftc8inx 7441 36 and and CC cord-010092-uftc8inx 7441 37 comparison comparison NN cord-010092-uftc8inx 7441 38 with with IN cord-010092-uftc8inx 7441 39 artificial artificial JJ cord-010092-uftc8inx 7441 40 eye eye NN cord-010092-uftc8inx 7441 41 drops drop VBZ cord-010092-uftc8inx 7441 42 or or CC cord-010092-uftc8inx 7441 43 , , , cord-010092-uftc8inx 7441 44 if if IN cord-010092-uftc8inx 7441 45 applicable applicable JJ cord-010092-uftc8inx 7441 46 , , , cord-010092-uftc8inx 7441 47 with with IN cord-010092-uftc8inx 7441 48 Auto auto NN cord-010092-uftc8inx 7441 49 - - HYPH cord-010092-uftc8inx 7441 50 SED SED NNP cord-010092-uftc8inx 7441 51 . . . cord-010092-uftc8inx 7442 1 Furthermore furthermore RB cord-010092-uftc8inx 7442 2 patients patient NNS cord-010092-uftc8inx 7442 3 are be VBP cord-010092-uftc8inx 7442 4 undergoing undergo VBG cord-010092-uftc8inx 7442 5 regular regular JJ cord-010092-uftc8inx 7442 6 ophthalmologic ophthalmologic JJ cord-010092-uftc8inx 7442 7 examination examination NN cord-010092-uftc8inx 7442 8 within within IN cord-010092-uftc8inx 7442 9 a a DT cord-010092-uftc8inx 7442 10 special special JJ cord-010092-uftc8inx 7442 11 consultation consultation NN cord-010092-uftc8inx 7442 12 for for IN cord-010092-uftc8inx 7442 13 dry dry JJ cord-010092-uftc8inx 7442 14 eye eye NN cord-010092-uftc8inx 7442 15 syndrome syndrome NN cord-010092-uftc8inx 7442 16 at at IN cord-010092-uftc8inx 7442 17 our -PRON- PRP$ cord-010092-uftc8inx 7442 18 hospital hospital NN cord-010092-uftc8inx 7442 19 . . . cord-010092-uftc8inx 7443 1 Results result NNS cord-010092-uftc8inx 7443 2 : : : cord-010092-uftc8inx 7443 3 31 31 CD cord-010092-uftc8inx 7443 4 patients patient NNS cord-010092-uftc8inx 7443 5 were be VBD cord-010092-uftc8inx 7443 6 identified identify VBN cord-010092-uftc8inx 7443 7 receiving receive VBG cord-010092-uftc8inx 7443 8 allogeneic allogeneic NN cord-010092-uftc8inx 7443 9 SED sed NN cord-010092-uftc8inx 7443 10 , , , cord-010092-uftc8inx 7443 11 15 15 CD cord-010092-uftc8inx 7443 12 patients patient NNS cord-010092-uftc8inx 7443 13 had have VBD cord-010092-uftc8inx 7443 14 been be VBN cord-010092-uftc8inx 7443 15 treated treat VBN cord-010092-uftc8inx 7443 16 autologous autologous JJ cord-010092-uftc8inx 7443 17 previously previously RB cord-010092-uftc8inx 7443 18 . . . cord-010092-uftc8inx 7444 1 In in IN cord-010092-uftc8inx 7444 2 total total JJ cord-010092-uftc8inx 7444 3 , , , cord-010092-uftc8inx 7444 4 allogeneic allogeneic NN cord-010092-uftc8inx 7444 5 SED sed NN cord-010092-uftc8inx 7444 6 have have VBP cord-010092-uftc8inx 7444 7 been be VBN cord-010092-uftc8inx 7444 8 produced produce VBN cord-010092-uftc8inx 7444 9 54 54 CD cord-010092-uftc8inx 7444 10 times time NNS cord-010092-uftc8inx 7444 11 since since IN cord-010092-uftc8inx 7444 12 June June NNP cord-010092-uftc8inx 7444 13 2017 2017 CD cord-010092-uftc8inx 7444 14 . . . cord-010092-uftc8inx 7445 1 Indications indication NNS cord-010092-uftc8inx 7445 2 were be VBD cord-010092-uftc8inx 7445 3 ocular ocular JJ cord-010092-uftc8inx 7445 4 GvHD gvhd NN cord-010092-uftc8inx 7446 1 ( ( -LRB- cord-010092-uftc8inx 7446 2 n n NN cord-010092-uftc8inx 7446 3 = = SYM cord-010092-uftc8inx 7446 4 15.48 15.48 CD cord-010092-uftc8inx 7446 5 % % NN cord-010092-uftc8inx 7446 6 ) ) -RRB- cord-010092-uftc8inx 7446 7 , , , cord-010092-uftc8inx 7446 8 neurotrophic neurotrophic NNP cord-010092-uftc8inx 7446 9 keratopathy keratopathy NNP cord-010092-uftc8inx 7446 10 ( ( -LRB- cord-010092-uftc8inx 7446 11 n n NN cord-010092-uftc8inx 7446 12 = = SYM cord-010092-uftc8inx 7446 13 9.29 9.29 CD cord-010092-uftc8inx 7446 14 % % NN cord-010092-uftc8inx 7446 15 ) ) -RRB- cord-010092-uftc8inx 7446 16 , , , cord-010092-uftc8inx 7446 17 mucous mucous JJ cord-010092-uftc8inx 7446 18 membrane membrane NN cord-010092-uftc8inx 7446 19 pemphigoid pemphigoid NNP cord-010092-uftc8inx 7446 20 ( ( -LRB- cord-010092-uftc8inx 7446 21 n n NN cord-010092-uftc8inx 7446 22 = = SYM cord-010092-uftc8inx 7446 23 2.7 2.7 CD cord-010092-uftc8inx 7446 24 % % NN cord-010092-uftc8inx 7446 25 ) ) -RRB- cord-010092-uftc8inx 7446 26 , , . cord-010092-uftc8inx 7447 1 Sj€ Sj€ NNP cord-010092-uftc8inx 7447 2 ogren ogren NNP cord-010092-uftc8inx 7447 3 Syndrome Syndrome NNP cord-010092-uftc8inx 7447 4 ( ( -LRB- cord-010092-uftc8inx 7447 5 n n NN cord-010092-uftc8inx 7447 6 = = SYM cord-010092-uftc8inx 7447 7 1.3 1.3 CD cord-010092-uftc8inx 7447 8 % % NN cord-010092-uftc8inx 7447 9 ) ) -RRB- cord-010092-uftc8inx 7447 10 and and CC cord-010092-uftc8inx 7447 11 secondary secondary JJ cord-010092-uftc8inx 7447 12 keratoconjunctivitis keratoconjunctivitis NNP cord-010092-uftc8inx 7447 13 sicca sicca NNP cord-010092-uftc8inx 7447 14 by by IN cord-010092-uftc8inx 7447 15 virtue virtue NN cord-010092-uftc8inx 7447 16 of of IN cord-010092-uftc8inx 7447 17 chemotherapy chemotherapy NN cord-010092-uftc8inx 7447 18 , , , cord-010092-uftc8inx 7447 19 Meige Meige NNP cord-010092-uftc8inx 7447 20 syndrome syndrome NN cord-010092-uftc8inx 7447 21 , , , cord-010092-uftc8inx 7447 22 rosacea rosacea NN cord-010092-uftc8inx 7447 23 , , , cord-010092-uftc8inx 7447 24 Morbus Morbus NNP cord-010092-uftc8inx 7447 25 Bruton Bruton NNP cord-010092-uftc8inx 7447 26 ( ( -LRB- cord-010092-uftc8inx 7447 27 n n NN cord-010092-uftc8inx 7447 28 = = SYM cord-010092-uftc8inx 7447 29 4.13 4.13 CD cord-010092-uftc8inx 7447 30 % % NN cord-010092-uftc8inx 7447 31 ) ) -RRB- cord-010092-uftc8inx 7447 32 . . . cord-010092-uftc8inx 7448 1 Contraindications Contraindications NNP cord-010092-uftc8inx 7448 2 for for IN cord-010092-uftc8inx 7448 3 autologous autologous JJ cord-010092-uftc8inx 7448 4 donation donation NN cord-010092-uftc8inx 7448 5 were be VBD cord-010092-uftc8inx 7448 6 underlying underlie VBG cord-010092-uftc8inx 7448 7 disease disease NN cord-010092-uftc8inx 7448 8 ( ( -LRB- cord-010092-uftc8inx 7448 9 n n NN cord-010092-uftc8inx 7448 10 = = SYM cord-010092-uftc8inx 7448 11 19.61 19.61 CD cord-010092-uftc8inx 7448 12 % % NN cord-010092-uftc8inx 7448 13 ) ) -RRB- cord-010092-uftc8inx 7448 14 , , , cord-010092-uftc8inx 7448 15 poor poor JJ cord-010092-uftc8inx 7448 16 venous venous JJ cord-010092-uftc8inx 7448 17 access access NN cord-010092-uftc8inx 7448 18 ( ( -LRB- cord-010092-uftc8inx 7448 19 n n NN cord-010092-uftc8inx 7448 20 = = SYM cord-010092-uftc8inx 7448 21 12.38 12.38 CD cord-010092-uftc8inx 7448 22 % % NN cord-010092-uftc8inx 7448 23 ) ) -RRB- cord-010092-uftc8inx 7448 24 , , , cord-010092-uftc8inx 7448 25 low low JJ cord-010092-uftc8inx 7448 26 haemoglobin haemoglobin NN cord-010092-uftc8inx 7448 27 ( ( -LRB- cord-010092-uftc8inx 7448 28 n n NN cord-010092-uftc8inx 7448 29 = = SYM cord-010092-uftc8inx 7448 30 8.25 8.25 CD cord-010092-uftc8inx 7448 31 % % NN cord-010092-uftc8inx 7448 32 ) ) -RRB- cord-010092-uftc8inx 7448 33 , , , cord-010092-uftc8inx 7448 34 low low JJ cord-010092-uftc8inx 7448 35 body body NN cord-010092-uftc8inx 7448 36 weight weight NN cord-010092-uftc8inx 7448 37 ( ( -LRB- cord-010092-uftc8inx 7448 38 n n NN cord-010092-uftc8inx 7448 39 = = SYM cord-010092-uftc8inx 7448 40 8.25 8.25 CD cord-010092-uftc8inx 7448 41 % % NN cord-010092-uftc8inx 7448 42 ) ) -RRB- cord-010092-uftc8inx 7448 43 , , , cord-010092-uftc8inx 7448 44 very very RB cord-010092-uftc8inx 7448 45 young young JJ cord-010092-uftc8inx 7448 46 age age NN cord-010092-uftc8inx 7448 47 ( ( -LRB- cord-010092-uftc8inx 7448 48 n n NN cord-010092-uftc8inx 7448 49 = = SYM cord-010092-uftc8inx 7448 50 7.22 7.22 CD cord-010092-uftc8inx 7448 51 % % NN cord-010092-uftc8inx 7448 52 ) ) -RRB- cord-010092-uftc8inx 7448 53 , , , cord-010092-uftc8inx 7448 54 circulatory circulatory JJ cord-010092-uftc8inx 7448 55 disturbances disturbance NNS cord-010092-uftc8inx 7448 56 ( ( -LRB- cord-010092-uftc8inx 7448 57 n n NN cord-010092-uftc8inx 7448 58 = = SYM cord-010092-uftc8inx 7448 59 3.10 3.10 CD cord-010092-uftc8inx 7448 60 % % NN cord-010092-uftc8inx 7448 61 ) ) -RRB- cord-010092-uftc8inx 7448 62 and and CC cord-010092-uftc8inx 7448 63 lack lack NN cord-010092-uftc8inx 7448 64 of of IN cord-010092-uftc8inx 7448 65 response response NN cord-010092-uftc8inx 7448 66 to to IN cord-010092-uftc8inx 7448 67 Auto Auto NNP cord-010092-uftc8inx 7448 68 - - HYPH cord-010092-uftc8inx 7448 69 SED SED NNP cord-010092-uftc8inx 7448 70 ( ( -LRB- cord-010092-uftc8inx 7448 71 n n NN cord-010092-uftc8inx 7448 72 = = SYM cord-010092-uftc8inx 7448 73 2.7 2.7 CD cord-010092-uftc8inx 7448 74 % % NN cord-010092-uftc8inx 7448 75 ) ) -RRB- cord-010092-uftc8inx 7448 76 . . . cord-010092-uftc8inx 7449 1 Some some DT cord-010092-uftc8inx 7449 2 patients patient NNS cord-010092-uftc8inx 7449 3 presented present VBD cord-010092-uftc8inx 7449 4 more more JJR cord-010092-uftc8inx 7449 5 than than IN cord-010092-uftc8inx 7449 6 one one CD cord-010092-uftc8inx 7449 7 contraindication contraindication NN cord-010092-uftc8inx 7449 8 . . . cord-010092-uftc8inx 7450 1 Manufacturing manufacturing NN cord-010092-uftc8inx 7450 2 problems problem NNS cord-010092-uftc8inx 7450 3 were be VBD cord-010092-uftc8inx 7450 4 : : : cord-010092-uftc8inx 7450 5 lipemic lipemic NNP cord-010092-uftc8inx 7450 6 donor donor NN cord-010092-uftc8inx 7450 7 plasma plasma NN cord-010092-uftc8inx 7450 8 ( ( -LRB- cord-010092-uftc8inx 7450 9 n n NN cord-010092-uftc8inx 7450 10 = = SYM cord-010092-uftc8inx 7450 11 2.4 2.4 CD cord-010092-uftc8inx 7450 12 % % NN cord-010092-uftc8inx 7450 13 ) ) -RRB- cord-010092-uftc8inx 7450 14 , , , cord-010092-uftc8inx 7450 15 high high JJ cord-010092-uftc8inx 7450 16 donor donor NN cord-010092-uftc8inx 7450 17 haemoglobin haemoglobin NN cord-010092-uftc8inx 7450 18 ( ( -LRB- cord-010092-uftc8inx 7450 19 n n NN cord-010092-uftc8inx 7450 20 = = SYM cord-010092-uftc8inx 7450 21 2.4 2.4 CD cord-010092-uftc8inx 7450 22 % % NN cord-010092-uftc8inx 7450 23 ) ) -RRB- cord-010092-uftc8inx 7450 24 and and CC cord-010092-uftc8inx 7450 25 unspecific unspecific JJ cord-010092-uftc8inx 7450 26 positive positive JJ cord-010092-uftc8inx 7450 27 serological serological JJ cord-010092-uftc8inx 7450 28 findings finding NNS cord-010092-uftc8inx 7450 29 ( ( -LRB- cord-010092-uftc8inx 7450 30 Anti Anti NNP cord-010092-uftc8inx 7450 31 - - NNP cord-010092-uftc8inx 7450 32 HBs HBs NNP cord-010092-uftc8inx 7450 33 n n NNP cord-010092-uftc8inx 7450 34 = = SYM cord-010092-uftc8inx 7450 35 2.4 2.4 CD cord-010092-uftc8inx 7450 36 % % NN cord-010092-uftc8inx 7450 37 ) ) -RRB- cord-010092-uftc8inx 7450 38 . . . cord-010092-uftc8inx 7451 1 Microbiological microbiological JJ cord-010092-uftc8inx 7451 2 testing testing NN cord-010092-uftc8inx 7451 3 was be VBD cord-010092-uftc8inx 7451 4 sterile sterile JJ cord-010092-uftc8inx 7451 5 every every DT cord-010092-uftc8inx 7451 6 time time NN cord-010092-uftc8inx 7451 7 . . . cord-010092-uftc8inx 7452 1 As as IN cord-010092-uftc8inx 7452 2 side side NN cord-010092-uftc8inx 7452 3 effects effect NNS cord-010092-uftc8inx 7452 4 one one CD cord-010092-uftc8inx 7452 5 case case NN cord-010092-uftc8inx 7452 6 of of IN cord-010092-uftc8inx 7452 7 allergic allergic JJ cord-010092-uftc8inx 7452 8 reaction reaction NN cord-010092-uftc8inx 7452 9 , , , cord-010092-uftc8inx 7452 10 suspected suspect VBN cord-010092-uftc8inx 7452 11 as as IN cord-010092-uftc8inx 7452 12 serum serum NN cord-010092-uftc8inx 7452 13 protein protein NN cord-010092-uftc8inx 7452 14 allergy allergy NN cord-010092-uftc8inx 7452 15 , , , cord-010092-uftc8inx 7452 16 appeared appear VBD cord-010092-uftc8inx 7452 17 . . . cord-010092-uftc8inx 7453 1 Clinical clinical JJ cord-010092-uftc8inx 7453 2 outcome outcome NN cord-010092-uftc8inx 7453 3 can can MD cord-010092-uftc8inx 7453 4 be be VB cord-010092-uftc8inx 7453 5 considered consider VBN cord-010092-uftc8inx 7453 6 equivalent equivalent JJ cord-010092-uftc8inx 7453 7 to to IN cord-010092-uftc8inx 7453 8 ASED ASED NNP cord-010092-uftc8inx 7453 9 . . . cord-010092-uftc8inx 7454 1 Subjectively subjectively RB cord-010092-uftc8inx 7454 2 , , , cord-010092-uftc8inx 7454 3 all all DT cord-010092-uftc8inx 7454 4 patients patient NNS cord-010092-uftc8inx 7454 5 benefited benefit VBD cord-010092-uftc8inx 7454 6 from from IN cord-010092-uftc8inx 7454 7 the the DT cord-010092-uftc8inx 7454 8 therapy therapy NN cord-010092-uftc8inx 7454 9 and and CC cord-010092-uftc8inx 7454 10 reported report VBD cord-010092-uftc8inx 7454 11 an an DT cord-010092-uftc8inx 7454 12 alleviation alleviation NN cord-010092-uftc8inx 7454 13 of of IN cord-010092-uftc8inx 7454 14 their -PRON- PRP$ cord-010092-uftc8inx 7454 15 symptoms symptom NNS cord-010092-uftc8inx 7454 16 . . . cord-010092-uftc8inx 7455 1 For for IN cord-010092-uftc8inx 7455 2 some some DT cord-010092-uftc8inx 7455 3 indications indication NNS cord-010092-uftc8inx 7455 4 ( ( -LRB- cord-010092-uftc8inx 7455 5 highly highly RB cord-010092-uftc8inx 7455 6 active active JJ cord-010092-uftc8inx 7455 7 GvHD gvhd NN cord-010092-uftc8inx 7455 8 ) ) -RRB- cord-010092-uftc8inx 7455 9 Allo allo NN cord-010092-uftc8inx 7455 10 - - HYPH cord-010092-uftc8inx 7455 11 SED sed NN cord-010092-uftc8inx 7455 12 might may MD cord-010092-uftc8inx 7455 13 even even RB cord-010092-uftc8inx 7455 14 be be VB cord-010092-uftc8inx 7455 15 the the DT cord-010092-uftc8inx 7455 16 better well JJR cord-010092-uftc8inx 7455 17 option option NN cord-010092-uftc8inx 7455 18 . . . cord-010092-uftc8inx 7456 1 Summary Summary NNP cord-010092-uftc8inx 7456 2 / / SYM cord-010092-uftc8inx 7456 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 7456 4 : : : cord-010092-uftc8inx 7457 1 Considering consider VBG cord-010092-uftc8inx 7457 2 our -PRON- PRP$ cord-010092-uftc8inx 7457 3 previous previous JJ cord-010092-uftc8inx 7457 4 experience experience NN cord-010092-uftc8inx 7457 5 , , , cord-010092-uftc8inx 7457 6 Allo allo NN cord-010092-uftc8inx 7457 7 - - HYPH cord-010092-uftc8inx 7457 8 SED sed NN cord-010092-uftc8inx 7457 9 seem seem VBP cord-010092-uftc8inx 7457 10 to to TO cord-010092-uftc8inx 7457 11 be be VB cord-010092-uftc8inx 7457 12 a a DT cord-010092-uftc8inx 7457 13 safe safe JJ cord-010092-uftc8inx 7457 14 and and CC cord-010092-uftc8inx 7457 15 equally equally RB cord-010092-uftc8inx 7457 16 effective effective JJ cord-010092-uftc8inx 7457 17 alternative alternative NN cord-010092-uftc8inx 7457 18 to to IN cord-010092-uftc8inx 7457 19 Auto auto NN cord-010092-uftc8inx 7457 20 - - HYPH cord-010092-uftc8inx 7457 21 SED SED NNP cord-010092-uftc8inx 7457 22 for for IN cord-010092-uftc8inx 7457 23 patients patient NNS cord-010092-uftc8inx 7457 24 unable unable JJ cord-010092-uftc8inx 7457 25 to to TO cord-010092-uftc8inx 7457 26 donate donate VB cord-010092-uftc8inx 7457 27 blood blood NN cord-010092-uftc8inx 7457 28 . . . cord-010092-uftc8inx 7458 1 In in IN cord-010092-uftc8inx 7458 2 case case NN cord-010092-uftc8inx 7458 3 of of IN cord-010092-uftc8inx 7458 4 urgent urgent JJ cord-010092-uftc8inx 7458 5 indication indication NN cord-010092-uftc8inx 7458 6 , , , cord-010092-uftc8inx 7458 7 timely timely JJ cord-010092-uftc8inx 7458 8 supply supply NN cord-010092-uftc8inx 7458 9 can can MD cord-010092-uftc8inx 7458 10 sometimes sometimes RB cord-010092-uftc8inx 7458 11 be be VB cord-010092-uftc8inx 7458 12 difficult difficult JJ cord-010092-uftc8inx 7458 13 . . . cord-010092-uftc8inx 7459 1 To to TO cord-010092-uftc8inx 7459 2 overcome overcome VB cord-010092-uftc8inx 7459 3 this this DT cord-010092-uftc8inx 7459 4 disadvantage disadvantage NN cord-010092-uftc8inx 7459 5 licensing licensing NN cord-010092-uftc8inx 7459 6 Allo allo NN cord-010092-uftc8inx 7459 7 - - HYPH cord-010092-uftc8inx 7459 8 SED SED NNP cord-010092-uftc8inx 7459 9 as as IN cord-010092-uftc8inx 7459 10 a a DT cord-010092-uftc8inx 7459 11 new new JJ cord-010092-uftc8inx 7459 12 blood blood NN cord-010092-uftc8inx 7459 13 product product NN cord-010092-uftc8inx 7459 14 with with IN cord-010092-uftc8inx 7459 15 the the DT cord-010092-uftc8inx 7459 16 possibility possibility NN cord-010092-uftc8inx 7459 17 of of IN cord-010092-uftc8inx 7459 18 production production NN cord-010092-uftc8inx 7459 19 and and CC cord-010092-uftc8inx 7459 20 storage storage NN cord-010092-uftc8inx 7459 21 in in IN cord-010092-uftc8inx 7459 22 advance advance NN cord-010092-uftc8inx 7459 23 would would MD cord-010092-uftc8inx 7459 24 be be VB cord-010092-uftc8inx 7459 25 a a DT cord-010092-uftc8inx 7459 26 desirable desirable JJ cord-010092-uftc8inx 7459 27 goal goal NN cord-010092-uftc8inx 7459 28 . . . cord-010092-uftc8inx 7460 1 In in IN cord-010092-uftc8inx 7460 2 addition addition NN cord-010092-uftc8inx 7460 3 supply supply NN cord-010092-uftc8inx 7460 4 would would MD cord-010092-uftc8inx 7460 5 become become VB cord-010092-uftc8inx 7460 6 even even RB cord-010092-uftc8inx 7460 7 safer safe JJR cord-010092-uftc8inx 7460 8 by by IN cord-010092-uftc8inx 7460 9 preparing prepare VBG cord-010092-uftc8inx 7460 10 Allo Allo NNP cord-010092-uftc8inx 7460 11 - - HYPH cord-010092-uftc8inx 7460 12 SED sed NN cord-010092-uftc8inx 7460 13 according accord VBG cord-010092-uftc8inx 7460 14 to to IN cord-010092-uftc8inx 7460 15 a a DT cord-010092-uftc8inx 7460 16 quarantine quarantine NN cord-010092-uftc8inx 7460 17 principle principle NN cord-010092-uftc8inx 7460 18 like like IN cord-010092-uftc8inx 7460 19 FFP FFP NNP cord-010092-uftc8inx 7460 20 . . . cord-010092-uftc8inx 7461 1 Abstract Abstract NNP cord-010092-uftc8inx 7461 2 withdrawn withdraw VBN cord-010092-uftc8inx 7461 3 . . . cord-010092-uftc8inx 7462 1 Background background NN cord-010092-uftc8inx 7462 2 : : : cord-010092-uftc8inx 7463 1 Vernal Vernal NNP cord-010092-uftc8inx 7463 2 keratoconjunctivitis keratoconjunctivitis NNP cord-010092-uftc8inx 7463 3 is be VBZ cord-010092-uftc8inx 7463 4 a a DT cord-010092-uftc8inx 7463 5 chronic chronic JJ cord-010092-uftc8inx 7463 6 , , , cord-010092-uftc8inx 7463 7 recurrent recurrent JJ cord-010092-uftc8inx 7463 8 bilateral bilateral JJ cord-010092-uftc8inx 7463 9 inflammation inflammation NN cord-010092-uftc8inx 7463 10 of of IN cord-010092-uftc8inx 7463 11 the the DT cord-010092-uftc8inx 7463 12 outer outer JJ cord-010092-uftc8inx 7463 13 ocular ocular JJ cord-010092-uftc8inx 7463 14 layer layer NN cord-010092-uftc8inx 7463 15 . . . cord-010092-uftc8inx 7464 1 Mostly mostly RB cord-010092-uftc8inx 7464 2 affected affect VBN cord-010092-uftc8inx 7464 3 are be VBP cord-010092-uftc8inx 7464 4 children child NNS cord-010092-uftc8inx 7464 5 and and CC cord-010092-uftc8inx 7464 6 young young JJ cord-010092-uftc8inx 7464 7 people people NNS cord-010092-uftc8inx 7464 8 and and CC cord-010092-uftc8inx 7464 9 the the DT cord-010092-uftc8inx 7464 10 condition condition NN cord-010092-uftc8inx 7464 11 is be VBZ cord-010092-uftc8inx 7464 12 more more RBR cord-010092-uftc8inx 7464 13 common common JJ cord-010092-uftc8inx 7464 14 in in IN cord-010092-uftc8inx 7464 15 boys boy NNS cord-010092-uftc8inx 7464 16 . . . cord-010092-uftc8inx 7465 1 The the DT cord-010092-uftc8inx 7465 2 disease disease NN cord-010092-uftc8inx 7465 3 presents present VBZ cord-010092-uftc8inx 7465 4 with with IN cord-010092-uftc8inx 7465 5 eye eye NN cord-010092-uftc8inx 7465 6 pruritus pruritus NN cord-010092-uftc8inx 7465 7 ( ( -LRB- cord-010092-uftc8inx 7465 8 itching itch VBG cord-010092-uftc8inx 7465 9 eye eye NN cord-010092-uftc8inx 7465 10 ) ) -RRB- cord-010092-uftc8inx 7465 11 , , , cord-010092-uftc8inx 7465 12 photophobia photophobia NN cord-010092-uftc8inx 7465 13 ( ( -LRB- cord-010092-uftc8inx 7465 14 sensitivity sensitivity NN cord-010092-uftc8inx 7465 15 to to IN cord-010092-uftc8inx 7465 16 bright bright JJ cord-010092-uftc8inx 7465 17 light light NN cord-010092-uftc8inx 7465 18 ) ) -RRB- cord-010092-uftc8inx 7465 19 , , , cord-010092-uftc8inx 7465 20 excessive excessive JJ cord-010092-uftc8inx 7465 21 tearing tearing NN cord-010092-uftc8inx 7465 22 and and CC cord-010092-uftc8inx 7465 23 foreign foreign JJ cord-010092-uftc8inx 7465 24 eye eye NN cord-010092-uftc8inx 7465 25 syndrome syndrome NN cord-010092-uftc8inx 7465 26 . . . cord-010092-uftc8inx 7466 1 Severe severe JJ cord-010092-uftc8inx 7466 2 cases case NNS cord-010092-uftc8inx 7466 3 manifest manifest VBP cord-010092-uftc8inx 7466 4 with with IN cord-010092-uftc8inx 7466 5 diffusion diffusion NN cord-010092-uftc8inx 7466 6 of of IN cord-010092-uftc8inx 7466 7 overgrown overgrown JJ cord-010092-uftc8inx 7466 8 papillae papilla NNS cord-010092-uftc8inx 7466 9 usually usually RB cord-010092-uftc8inx 7466 10 of of IN cord-010092-uftc8inx 7466 11 the the DT cord-010092-uftc8inx 7466 12 upper upper JJ cord-010092-uftc8inx 7466 13 eyelid eyelid NN cord-010092-uftc8inx 7466 14 , , , cord-010092-uftc8inx 7466 15 bursting burst VBG cord-010092-uftc8inx 7466 16 of of IN cord-010092-uftc8inx 7466 17 the the DT cord-010092-uftc8inx 7466 18 connective connective JJ cord-010092-uftc8inx 7466 19 tissue tissue NN cord-010092-uftc8inx 7466 20 barriers barrier NNS cord-010092-uftc8inx 7466 21 and and CC cord-010092-uftc8inx 7466 22 appearance appearance NN cord-010092-uftc8inx 7466 23 of of IN cord-010092-uftc8inx 7466 24 giant giant JJ cord-010092-uftc8inx 7466 25 papillae papilla NNS cord-010092-uftc8inx 7466 26 that that WDT cord-010092-uftc8inx 7466 27 press press VBP cord-010092-uftc8inx 7466 28 on on IN cord-010092-uftc8inx 7466 29 the the DT cord-010092-uftc8inx 7466 30 cornea cornea NN cord-010092-uftc8inx 7466 31 . . . cord-010092-uftc8inx 7467 1 Corneal corneal JJ cord-010092-uftc8inx 7467 2 ulceration ulceration NN cord-010092-uftc8inx 7467 3 is be VBZ cord-010092-uftc8inx 7467 4 a a DT cord-010092-uftc8inx 7467 5 severe severe JJ cord-010092-uftc8inx 7467 6 complication complication NN cord-010092-uftc8inx 7467 7 of of IN cord-010092-uftc8inx 7467 8 vernal vernal JJ cord-010092-uftc8inx 7467 9 keratoconjunctivitis keratoconjunctivitis NNP cord-010092-uftc8inx 7467 10 that that WDT cord-010092-uftc8inx 7467 11 may may MD cord-010092-uftc8inx 7467 12 induce induce VB cord-010092-uftc8inx 7467 13 scarring scarring NN cord-010092-uftc8inx 7467 14 , , , cord-010092-uftc8inx 7467 15 corneal corneal JJ cord-010092-uftc8inx 7467 16 neovascularization neovascularization NN cord-010092-uftc8inx 7467 17 and and CC cord-010092-uftc8inx 7467 18 occasionally occasionally RB cord-010092-uftc8inx 7467 19 perforation perforation NN cord-010092-uftc8inx 7467 20 . . . cord-010092-uftc8inx 7468 1 Treatment treatment NN cord-010092-uftc8inx 7468 2 of of IN cord-010092-uftc8inx 7468 3 keratoconjunctivitis keratoconjunctivitis NNP cord-010092-uftc8inx 7468 4 mainly mainly RB cord-010092-uftc8inx 7468 5 relies rely VBZ cord-010092-uftc8inx 7468 6 on on IN cord-010092-uftc8inx 7468 7 steroids steroid NNS cord-010092-uftc8inx 7468 8 , , , cord-010092-uftc8inx 7468 9 mast mast NN cord-010092-uftc8inx 7468 10 cell cell NN cord-010092-uftc8inx 7468 11 stabilizers stabilizer NNS cord-010092-uftc8inx 7468 12 , , , cord-010092-uftc8inx 7468 13 antihistamines antihistamine NNS cord-010092-uftc8inx 7468 14 , , , cord-010092-uftc8inx 7468 15 immunosuppressive immunosuppressive JJ cord-010092-uftc8inx 7468 16 drugs drug NNS cord-010092-uftc8inx 7468 17 ( ( -LRB- cord-010092-uftc8inx 7468 18 cyclosporine cyclosporine NN cord-010092-uftc8inx 7468 19 ) ) -RRB- cord-010092-uftc8inx 7468 20 , , , cord-010092-uftc8inx 7468 21 artificial artificial JJ cord-010092-uftc8inx 7468 22 tears tear NNS cord-010092-uftc8inx 7468 23 , , , cord-010092-uftc8inx 7468 24 contact contact NN cord-010092-uftc8inx 7468 25 lensdressing lensdressing NN cord-010092-uftc8inx 7468 26 , , , cord-010092-uftc8inx 7468 27 cryotherapy cryotherapy NN cord-010092-uftc8inx 7468 28 and and CC cord-010092-uftc8inx 7468 29 surgical surgical JJ cord-010092-uftc8inx 7468 30 papillae papilla NNS cord-010092-uftc8inx 7468 31 removal removal NN cord-010092-uftc8inx 7468 32 . . . cord-010092-uftc8inx 7469 1 We -PRON- PRP cord-010092-uftc8inx 7469 2 present present VBP cord-010092-uftc8inx 7469 3 the the DT cord-010092-uftc8inx 7469 4 case case NN cord-010092-uftc8inx 7469 5 of of IN cord-010092-uftc8inx 7469 6 a a DT cord-010092-uftc8inx 7469 7 8 8 CD cord-010092-uftc8inx 7469 8 year year NN cord-010092-uftc8inx 7469 9 - - HYPH cord-010092-uftc8inx 7469 10 old old JJ cord-010092-uftc8inx 7469 11 girl girl NN cord-010092-uftc8inx 7469 12 with with IN cord-010092-uftc8inx 7469 13 corneal corneal JJ cord-010092-uftc8inx 7469 14 ulceration ulceration NN cord-010092-uftc8inx 7469 15 who who WP cord-010092-uftc8inx 7469 16 was be VBD cord-010092-uftc8inx 7469 17 applied apply VBN cord-010092-uftc8inx 7469 18 artificial artificial JJ cord-010092-uftc8inx 7469 19 tears tear NNS cord-010092-uftc8inx 7469 20 after after IN cord-010092-uftc8inx 7469 21 traditional traditional JJ cord-010092-uftc8inx 7469 22 methods method NNS cord-010092-uftc8inx 7469 23 of of IN cord-010092-uftc8inx 7469 24 treatment treatment NN cord-010092-uftc8inx 7469 25 proved prove VBD cord-010092-uftc8inx 7469 26 unsuccessful unsuccessful JJ cord-010092-uftc8inx 7469 27 . . . cord-010092-uftc8inx 7470 1 Aims aim VBZ cord-010092-uftc8inx 7470 2 : : : cord-010092-uftc8inx 7471 1 The the DT cord-010092-uftc8inx 7471 2 aim aim NN cord-010092-uftc8inx 7471 3 was be VBD cord-010092-uftc8inx 7471 4 to to TO cord-010092-uftc8inx 7471 5 share share VB cord-010092-uftc8inx 7471 6 our -PRON- PRP$ cord-010092-uftc8inx 7471 7 experience experience NN cord-010092-uftc8inx 7471 8 on on IN cord-010092-uftc8inx 7471 9 artificial artificial JJ cord-010092-uftc8inx 7471 10 tears tear NNS cord-010092-uftc8inx 7471 11 therapy therapy NN cord-010092-uftc8inx 7471 12 applied apply VBD cord-010092-uftc8inx 7471 13 in in IN cord-010092-uftc8inx 7471 14 ophthalmic ophthalmic JJ cord-010092-uftc8inx 7471 15 disorders disorder NNS cord-010092-uftc8inx 7471 16 . . . cord-010092-uftc8inx 7472 1 Methods method NNS cord-010092-uftc8inx 7472 2 : : : cord-010092-uftc8inx 7472 3 Autologous autologous JJ cord-010092-uftc8inx 7472 4 blood blood NN cord-010092-uftc8inx 7472 5 ( ( -LRB- cord-010092-uftc8inx 7472 6 20 20 CD cord-010092-uftc8inx 7472 7 ml ml NN cord-010092-uftc8inx 7472 8 ) ) -RRB- cord-010092-uftc8inx 7472 9 was be VBD cord-010092-uftc8inx 7472 10 collected collect VBN cord-010092-uftc8inx 7472 11 into into IN cord-010092-uftc8inx 7472 12 disposable disposable JJ cord-010092-uftc8inx 7472 13 , , , cord-010092-uftc8inx 7472 14 sterile sterile JJ cord-010092-uftc8inx 7472 15 transfer transfer NN cord-010092-uftc8inx 7472 16 bags bag NNS cord-010092-uftc8inx 7472 17 used use VBN cord-010092-uftc8inx 7472 18 for for IN cord-010092-uftc8inx 7472 19 routine routine JJ cord-010092-uftc8inx 7472 20 blood blood NN cord-010092-uftc8inx 7472 21 component component NN cord-010092-uftc8inx 7472 22 preparation preparation NN cord-010092-uftc8inx 7472 23 ( ( -LRB- cord-010092-uftc8inx 7472 24 no no DT cord-010092-uftc8inx 7472 25 anticoagulant anticoagulant NN cord-010092-uftc8inx 7472 26 ) ) -RRB- cord-010092-uftc8inx 7472 27 and and CC cord-010092-uftc8inx 7472 28 incubated incubate VBN cord-010092-uftc8inx 7472 29 for for IN cord-010092-uftc8inx 7472 30 1 1 CD cord-010092-uftc8inx 7472 31 h h NN cord-010092-uftc8inx 7472 32 at at IN cord-010092-uftc8inx 7472 33 37 37 CD cord-010092-uftc8inx 7472 34 ° ° NN cord-010092-uftc8inx 7472 35 C c NN cord-010092-uftc8inx 7472 36 . . . cord-010092-uftc8inx 7473 1 The the DT cord-010092-uftc8inx 7473 2 clot clot NN cord-010092-uftc8inx 7473 3 was be VBD cord-010092-uftc8inx 7473 4 then then RB cord-010092-uftc8inx 7473 5 removed remove VBN cord-010092-uftc8inx 7473 6 by by IN cord-010092-uftc8inx 7473 7 centrifugation centrifugation NN cord-010092-uftc8inx 7473 8 and and CC cord-010092-uftc8inx 7473 9 the the DT cord-010092-uftc8inx 7473 10 serum serum NN cord-010092-uftc8inx 7473 11 containing containing NN cord-010092-uftc8inx 7473 12 erythrocytes erythrocyte NNS cord-010092-uftc8inx 7474 1 was be VBD cord-010092-uftc8inx 7474 2 press press NN cord-010092-uftc8inx 7474 3 extracted extract VBN cord-010092-uftc8inx 7474 4 . . . cord-010092-uftc8inx 7475 1 Centrifugation Centrifugation NNP cord-010092-uftc8inx 7475 2 was be VBD cord-010092-uftc8inx 7475 3 applied apply VBN cord-010092-uftc8inx 7475 4 again again RB cord-010092-uftc8inx 7475 5 to to TO cord-010092-uftc8inx 7475 6 obtain obtain VB cord-010092-uftc8inx 7475 7 serum serum NN cord-010092-uftc8inx 7475 8 free free JJ cord-010092-uftc8inx 7475 9 of of IN cord-010092-uftc8inx 7475 10 cellular cellular JJ cord-010092-uftc8inx 7475 11 components component NNS cord-010092-uftc8inx 7475 12 . . . cord-010092-uftc8inx 7476 1 The the DT cord-010092-uftc8inx 7476 2 serum serum NN cord-010092-uftc8inx 7476 3 was be VBD cord-010092-uftc8inx 7476 4 then then RB cord-010092-uftc8inx 7476 5 divided divide VBN cord-010092-uftc8inx 7476 6 into into IN cord-010092-uftc8inx 7476 7 0.3 0.3 CD cord-010092-uftc8inx 7476 8 ml ml NN cord-010092-uftc8inx 7476 9 segments segment NNS cord-010092-uftc8inx 7476 10 ( ( -LRB- cord-010092-uftc8inx 7476 11 capsules)and capsules)and VB cord-010092-uftc8inx 7476 12 the the DT cord-010092-uftc8inx 7476 13 artificial artificial JJ cord-010092-uftc8inx 7476 14 tears tear NNS cord-010092-uftc8inx 7476 15 applied apply VBD cord-010092-uftc8inx 7476 16 to to IN cord-010092-uftc8inx 7476 17 the the DT cord-010092-uftc8inx 7476 18 left left JJ cord-010092-uftc8inx 7476 19 eye eye NN cord-010092-uftc8inx 7476 20 8 8 CD cord-010092-uftc8inx 7476 21 9 9 CD cord-010092-uftc8inx 7476 22 daily daily NN cord-010092-uftc8inx 7476 23 . . . cord-010092-uftc8inx 7477 1 Results result NNS cord-010092-uftc8inx 7477 2 : : : cord-010092-uftc8inx 7478 1 Ulcer ulcer NN cord-010092-uftc8inx 7478 2 healing healing NN cord-010092-uftc8inx 7478 3 was be VBD cord-010092-uftc8inx 7478 4 reported report VBN cord-010092-uftc8inx 7478 5 after after IN cord-010092-uftc8inx 7478 6 4 4 CD cord-010092-uftc8inx 7478 7 weeks week NNS cord-010092-uftc8inx 7478 8 of of IN cord-010092-uftc8inx 7478 9 therapy therapy NN cord-010092-uftc8inx 7478 10 with with IN cord-010092-uftc8inx 7478 11 artificial artificial JJ cord-010092-uftc8inx 7478 12 tears tear NNS cord-010092-uftc8inx 7478 13 . . . cord-010092-uftc8inx 7479 1 The the DT cord-010092-uftc8inx 7479 2 dosage dosage NN cord-010092-uftc8inx 7479 3 was be VBD cord-010092-uftc8inx 7479 4 reduced reduce VBN cord-010092-uftc8inx 7479 5 to to IN cord-010092-uftc8inx 7479 6 4 4 CD cord-010092-uftc8inx 7479 7 9 9 CD cord-010092-uftc8inx 7479 8 daily daily RB cord-010092-uftc8inx 7479 9 . . . cord-010092-uftc8inx 7480 1 No no DT cord-010092-uftc8inx 7480 2 recurrence recurrence NN cord-010092-uftc8inx 7480 3 of of IN cord-010092-uftc8inx 7480 4 corneal corneal JJ cord-010092-uftc8inx 7480 5 ulceration ulceration NN cord-010092-uftc8inx 7480 6 was be VBD cord-010092-uftc8inx 7480 7 observed observe VBN cord-010092-uftc8inx 7480 8 after after IN cord-010092-uftc8inx 7480 9 subsequent subsequent JJ cord-010092-uftc8inx 7480 10 8 8 CD cord-010092-uftc8inx 7480 11 weeks week NNS cord-010092-uftc8inx 7480 12 . . . cord-010092-uftc8inx 7481 1 Summary Summary NNP cord-010092-uftc8inx 7481 2 / / SYM cord-010092-uftc8inx 7481 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 7481 4 : : : cord-010092-uftc8inx 7482 1 Artificial artificial JJ cord-010092-uftc8inx 7482 2 tears tear NNS cord-010092-uftc8inx 7482 3 are be VBP cord-010092-uftc8inx 7482 4 a a DT cord-010092-uftc8inx 7482 5 safe safe JJ cord-010092-uftc8inx 7482 6 and and CC cord-010092-uftc8inx 7482 7 effective effective JJ cord-010092-uftc8inx 7482 8 therapy therapy NN cord-010092-uftc8inx 7482 9 for for IN cord-010092-uftc8inx 7482 10 ophthalmic ophthalmic JJ cord-010092-uftc8inx 7482 11 disorders disorder NNS cord-010092-uftc8inx 7482 12 in in IN cord-010092-uftc8inx 7482 13 children child NNS cord-010092-uftc8inx 7482 14 . . . cord-010092-uftc8inx 7483 1 Background background NN cord-010092-uftc8inx 7483 2 : : : cord-010092-uftc8inx 7484 1 ARV ARV NNP cord-010092-uftc8inx 7484 2 non non JJ cord-010092-uftc8inx 7484 3 - - NN cord-010092-uftc8inx 7484 4 disclosure disclosure NN cord-010092-uftc8inx 7484 5 among among IN cord-010092-uftc8inx 7484 6 HIV HIV NNP cord-010092-uftc8inx 7484 7 - - HYPH cord-010092-uftc8inx 7484 8 positive positive JJ cord-010092-uftc8inx 7484 9 donors donor NNS cord-010092-uftc8inx 7484 10 who who WP cord-010092-uftc8inx 7484 11 tested test VBD cord-010092-uftc8inx 7484 12 HIV HIV NNP cord-010092-uftc8inx 7484 13 antibody antibody NN cord-010092-uftc8inx 7484 14 ( ( -LRB- cord-010092-uftc8inx 7484 15 Ab Ab NNP cord-010092-uftc8inx 7484 16 ) ) -RRB- cord-010092-uftc8inx 7484 17 positive positive JJ cord-010092-uftc8inx 7484 18 but but CC cord-010092-uftc8inx 7484 19 RNA RNA NNP cord-010092-uftc8inx 7484 20 negative negative JJ cord-010092-uftc8inx 7484 21 ( ( -LRB- cord-010092-uftc8inx 7484 22 Ab+/RNA- ab+/rna- CD cord-010092-uftc8inx 7484 23 ) ) -RRB- cord-010092-uftc8inx 7484 24 , , , cord-010092-uftc8inx 7484 25 so so RB cord-010092-uftc8inx 7484 26 - - HYPH cord-010092-uftc8inx 7484 27 called call VBN cord-010092-uftc8inx 7484 28 False False NNP cord-010092-uftc8inx 7484 29 Elite Elite NNP cord-010092-uftc8inx 7484 30 Controllers Controllers NNPS cord-010092-uftc8inx 7484 31 , , , cord-010092-uftc8inx 7484 32 was be VBD cord-010092-uftc8inx 7484 33 previously previously RB cord-010092-uftc8inx 7484 34 described describe VBN cord-010092-uftc8inx 7484 35 by by IN cord-010092-uftc8inx 7484 36 our -PRON- PRP$ cord-010092-uftc8inx 7484 37 group group NN cord-010092-uftc8inx 7484 38 in in IN cord-010092-uftc8inx 7484 39 South South NNP cord-010092-uftc8inx 7484 40 Africa Africa NNP cord-010092-uftc8inx 7484 41 , , , cord-010092-uftc8inx 7484 42 with with IN cord-010092-uftc8inx 7484 43 > > XX cord-010092-uftc8inx 7484 44 80 80 CD cord-010092-uftc8inx 7484 45 % % NN cord-010092-uftc8inx 7484 46 of of IN cord-010092-uftc8inx 7484 47 Ab+/RNAdonations ab+/rnadonation NNS cord-010092-uftc8inx 7484 48 since since IN cord-010092-uftc8inx 7484 49 2016 2016 CD cord-010092-uftc8inx 7484 50 testing test VBG cord-010092-uftc8inx 7484 51 ARV ARV NNP cord-010092-uftc8inx 7484 52 positive positive JJ cord-010092-uftc8inx 7484 53 . . . cord-010092-uftc8inx 7485 1 The the DT cord-010092-uftc8inx 7485 2 extent extent NN cord-010092-uftc8inx 7485 3 of of IN cord-010092-uftc8inx 7485 4 undisclosed undisclosed JJ cord-010092-uftc8inx 7485 5 ARV ARV NNP cord-010092-uftc8inx 7485 6 use use NN cord-010092-uftc8inx 7485 7 at at IN cord-010092-uftc8inx 7485 8 time time NN cord-010092-uftc8inx 7485 9 of of IN cord-010092-uftc8inx 7485 10 donation donation NN cord-010092-uftc8inx 7485 11 represents represent VBZ cord-010092-uftc8inx 7485 12 a a DT cord-010092-uftc8inx 7485 13 significant significant JJ cord-010092-uftc8inx 7485 14 risk risk NN cord-010092-uftc8inx 7485 15 to to IN cord-010092-uftc8inx 7485 16 blood blood NN cord-010092-uftc8inx 7485 17 safety safety NN cord-010092-uftc8inx 7485 18 in in IN cord-010092-uftc8inx 7485 19 a a DT cord-010092-uftc8inx 7485 20 country country NN cord-010092-uftc8inx 7485 21 with with IN cord-010092-uftc8inx 7485 22 a a DT cord-010092-uftc8inx 7485 23 growing grow VBG cord-010092-uftc8inx 7485 24 treated treat VBN cord-010092-uftc8inx 7485 25 HIV HIV NNP cord-010092-uftc8inx 7485 26 population population NN cord-010092-uftc8inx 7485 27 . . . cord-010092-uftc8inx 7486 1 Aims aim VBZ cord-010092-uftc8inx 7486 2 : : : cord-010092-uftc8inx 7487 1 To to TO cord-010092-uftc8inx 7487 2 establish establish VB cord-010092-uftc8inx 7487 3 the the DT cord-010092-uftc8inx 7487 4 prevalence prevalence NN cord-010092-uftc8inx 7487 5 of of IN cord-010092-uftc8inx 7487 6 ARV ARV NNP cord-010092-uftc8inx 7487 7 non non JJ cord-010092-uftc8inx 7487 8 - - NN cord-010092-uftc8inx 7487 9 disclosure disclosure NN cord-010092-uftc8inx 7487 10 among among IN cord-010092-uftc8inx 7487 11 four four CD cord-010092-uftc8inx 7487 12 subgroups subgroup NNS cord-010092-uftc8inx 7487 13 of of IN cord-010092-uftc8inx 7487 14 HIV HIV NNP cord-010092-uftc8inx 7487 15 - - HYPH cord-010092-uftc8inx 7487 16 positive positive JJ cord-010092-uftc8inx 7487 17 donors donor NNS cord-010092-uftc8inx 7487 18 in in IN cord-010092-uftc8inx 7487 19 South South NNP cord-010092-uftc8inx 7487 20 Africa Africa NNP cord-010092-uftc8inx 7487 21 along along IN cord-010092-uftc8inx 7487 22 with with IN cord-010092-uftc8inx 7487 23 demographic demographic JJ cord-010092-uftc8inx 7487 24 correlates correlate NNS cord-010092-uftc8inx 7487 25 of of IN cord-010092-uftc8inx 7487 26 non non JJ cord-010092-uftc8inx 7487 27 - - NN cord-010092-uftc8inx 7487 28 disclosure disclosure NN cord-010092-uftc8inx 7487 29 . . . cord-010092-uftc8inx 7488 1 Methods method NNS cord-010092-uftc8inx 7488 2 : : : cord-010092-uftc8inx 7489 1 South south JJ cord-010092-uftc8inx 7489 2 African african JJ cord-010092-uftc8inx 7489 3 blood blood NN cord-010092-uftc8inx 7489 4 donors donor NNS cord-010092-uftc8inx 7489 5 are be VBP cord-010092-uftc8inx 7489 6 screened screen VBN cord-010092-uftc8inx 7489 7 by by IN cord-010092-uftc8inx 7489 8 a a DT cord-010092-uftc8inx 7489 9 self self NN cord-010092-uftc8inx 7489 10 - - HYPH cord-010092-uftc8inx 7489 11 administered administer VBN cord-010092-uftc8inx 7489 12 questionnaire questionnaire NN cord-010092-uftc8inx 7489 13 , , , cord-010092-uftc8inx 7489 14 which which WDT cord-010092-uftc8inx 7489 15 includes include VBZ cord-010092-uftc8inx 7489 16 questions question NNS cord-010092-uftc8inx 7489 17 on on IN cord-010092-uftc8inx 7489 18 current current JJ cord-010092-uftc8inx 7489 19 HIV HIV NNP cord-010092-uftc8inx 7489 20 status status NN cord-010092-uftc8inx 7489 21 and and CC cord-010092-uftc8inx 7489 22 ARV ARV NNP cord-010092-uftc8inx 7489 23 use use NN cord-010092-uftc8inx 7489 24 , , , cord-010092-uftc8inx 7489 25 followed follow VBN cord-010092-uftc8inx 7489 26 by by IN cord-010092-uftc8inx 7489 27 a a DT cord-010092-uftc8inx 7489 28 semi semi JJ cord-010092-uftc8inx 7489 29 - - JJ cord-010092-uftc8inx 7489 30 structured structured JJ cord-010092-uftc8inx 7489 31 personal personal JJ cord-010092-uftc8inx 7489 32 interview interview NN cord-010092-uftc8inx 7489 33 . . . cord-010092-uftc8inx 7490 1 Specimens specimen NNS cord-010092-uftc8inx 7490 2 for for IN cord-010092-uftc8inx 7490 3 HIV HIV NNP cord-010092-uftc8inx 7490 4 , , , cord-010092-uftc8inx 7490 5 Hepatitis Hepatitis NNP cord-010092-uftc8inx 7490 6 B B NNP cord-010092-uftc8inx 7490 7 and and CC cord-010092-uftc8inx 7490 8 C C NNP cord-010092-uftc8inx 7490 9 testing testing NN cord-010092-uftc8inx 7490 10 are be VBP cord-010092-uftc8inx 7490 11 collected collect VBN cord-010092-uftc8inx 7490 12 at at IN cord-010092-uftc8inx 7490 13 time time NN cord-010092-uftc8inx 7490 14 of of IN cord-010092-uftc8inx 7490 15 donation donation NN cord-010092-uftc8inx 7490 16 . . . cord-010092-uftc8inx 7491 1 Based base VBN cord-010092-uftc8inx 7491 2 on on IN cord-010092-uftc8inx 7491 3 ID ID NNP cord-010092-uftc8inx 7491 4 - - HYPH cord-010092-uftc8inx 7491 5 NAT NAT NNP cord-010092-uftc8inx 7491 6 ( ( -LRB- cord-010092-uftc8inx 7491 7 Procleix Procleix NNP cord-010092-uftc8inx 7491 8 , , , cord-010092-uftc8inx 7491 9 Grifols Grifols NNP cord-010092-uftc8inx 7491 10 ) ) -RRB- cord-010092-uftc8inx 7491 11 and and CC cord-010092-uftc8inx 7491 12 antibody antibody NN cord-010092-uftc8inx 7491 13 ( ( -LRB- cord-010092-uftc8inx 7491 14 Prism Prism NNP cord-010092-uftc8inx 7491 15 , , , cord-010092-uftc8inx 7491 16 Abbott Abbott NNP cord-010092-uftc8inx 7491 17 ; ; : cord-010092-uftc8inx 7491 18 Western western JJ cord-010092-uftc8inx 7491 19 blot blot NN cord-010092-uftc8inx 7491 20 ) ) -RRB- cord-010092-uftc8inx 7491 21 testing testing NN cord-010092-uftc8inx 7491 22 , , , cord-010092-uftc8inx 7491 23 HIV HIV NNP cord-010092-uftc8inx 7491 24 - - HYPH cord-010092-uftc8inx 7491 25 positive positive JJ cord-010092-uftc8inx 7491 26 blood blood NN cord-010092-uftc8inx 7491 27 donations donation NNS cord-010092-uftc8inx 7491 28 were be VBD cord-010092-uftc8inx 7491 29 classified classify VBN cord-010092-uftc8inx 7491 30 as as IN cord-010092-uftc8inx 7491 31 acute acute JJ cord-010092-uftc8inx 7491 32 ( ( -LRB- cord-010092-uftc8inx 7491 33 Ab-/RNA+ ab-/rna+ NN cord-010092-uftc8inx 7491 34 ) ) -RRB- cord-010092-uftc8inx 7492 1 , , , cord-010092-uftc8inx 7492 2 recent recent JJ cord-010092-uftc8inx 7492 3 ( ( -LRB- cord-010092-uftc8inx 7492 4 Ab+/RNA+ Ab+/RNA+ NNP cord-010092-uftc8inx 7492 5 , , , cord-010092-uftc8inx 7492 6 Limiting limit VBG cord-010092-uftc8inx 7492 7 Antigen Antigen NNP cord-010092-uftc8inx 7492 8 Avidity Avidity NNP cord-010092-uftc8inx 7492 9 [ [ -LRB- cord-010092-uftc8inx 7492 10 LAg LAg NNS cord-010092-uftc8inx 7492 11 ] ] -RRB- cord-010092-uftc8inx 7492 12 ODn ODn NNS cord-010092-uftc8inx 7492 13 ≤ ≤ NNP cord-010092-uftc8inx 7492 14 1.5 1.5 CD cord-010092-uftc8inx 7492 15 ) ) -RRB- cord-010092-uftc8inx 7492 16 , , , cord-010092-uftc8inx 7492 17 longstanding longstanding JJ cord-010092-uftc8inx 7492 18 ( ( -LRB- cord-010092-uftc8inx 7492 19 Ab+/RNA+ Ab+/RNA+ NNP cord-010092-uftc8inx 7492 20 , , , cord-010092-uftc8inx 7492 21 LAg LAg NNS cord-010092-uftc8inx 7492 22 ODn ODn NNS cord-010092-uftc8inx 7492 23 > > XX cord-010092-uftc8inx 7492 24 1.5 1.5 CD cord-010092-uftc8inx 7492 25 ) ) -RRB- cord-010092-uftc8inx 7492 26 and and CC cord-010092-uftc8inx 7492 27 potential potential JJ cord-010092-uftc8inx 7492 28 Elite Elite NNP cord-010092-uftc8inx 7492 29 Controller Controller NNP cord-010092-uftc8inx 7492 30 ( ( -LRB- cord-010092-uftc8inx 7492 31 Ab+/RNA- Ab+/RNA- NNS cord-010092-uftc8inx 7492 32 ) ) -RRB- cord-010092-uftc8inx 7492 33 cases case NNS cord-010092-uftc8inx 7492 34 . . . cord-010092-uftc8inx 7493 1 Stored store VBN cord-010092-uftc8inx 7493 2 plasma plasma NN cord-010092-uftc8inx 7493 3 from from IN cord-010092-uftc8inx 7493 4 these these DT cord-010092-uftc8inx 7493 5 donations donation NNS cord-010092-uftc8inx 7493 6 were be VBD cord-010092-uftc8inx 7493 7 tested test VBN cord-010092-uftc8inx 7493 8 for for IN cord-010092-uftc8inx 7493 9 four four CD cord-010092-uftc8inx 7493 10 ARV ARV NNP cord-010092-uftc8inx 7493 11 drugs drug NNS cord-010092-uftc8inx 7493 12 using use VBG cord-010092-uftc8inx 7493 13 qualitative qualitative JJ cord-010092-uftc8inx 7493 14 liquid liquid JJ cord-010092-uftc8inx 7493 15 chromatography chromatography NN cord-010092-uftc8inx 7493 16 - - HYPH cord-010092-uftc8inx 7493 17 tandem tandem NN cord-010092-uftc8inx 7493 18 mass mass NN cord-010092-uftc8inx 7493 19 spectrometry spectrometry NN cord-010092-uftc8inx 7493 20 ( ( -LRB- cord-010092-uftc8inx 7493 21 detection detection NN cord-010092-uftc8inx 7493 22 limit limit NN cord-010092-uftc8inx 7493 23 0.02 0.02 CD cord-010092-uftc8inx 7493 24 lg lg NNP cord-010092-uftc8inx 7493 25 / / SYM cord-010092-uftc8inx 7493 26 mL mL NNP cord-010092-uftc8inx 7493 27 ) ) -RRB- cord-010092-uftc8inx 7493 28 . . . cord-010092-uftc8inx 7494 1 Chi Chi NNP cord-010092-uftc8inx 7494 2 - - HYPH cord-010092-uftc8inx 7494 3 square square JJ cord-010092-uftc8inx 7494 4 tests test NNS cord-010092-uftc8inx 7494 5 were be VBD cord-010092-uftc8inx 7494 6 used use VBN cord-010092-uftc8inx 7494 7 to to TO cord-010092-uftc8inx 7494 8 assess assess VB cord-010092-uftc8inx 7494 9 associations association NNS cord-010092-uftc8inx 7494 10 of of IN cord-010092-uftc8inx 7494 11 HIV HIV NNP cord-010092-uftc8inx 7494 12 case case NN cord-010092-uftc8inx 7494 13 type type NN cord-010092-uftc8inx 7494 14 , , , cord-010092-uftc8inx 7494 15 gender gender NN cord-010092-uftc8inx 7494 16 , , , cord-010092-uftc8inx 7494 17 ethnicity ethnicity NN cord-010092-uftc8inx 7494 18 , , , cord-010092-uftc8inx 7494 19 age age NN cord-010092-uftc8inx 7494 20 , , , cord-010092-uftc8inx 7494 21 donor donor NN cord-010092-uftc8inx 7494 22 type type NN cord-010092-uftc8inx 7494 23 , , , cord-010092-uftc8inx 7494 24 and and CC cord-010092-uftc8inx 7494 25 donor donor NN cord-010092-uftc8inx 7494 26 clinic clinic NN cord-010092-uftc8inx 7494 27 ( ( -LRB- cord-010092-uftc8inx 7494 28 fixed fix VBN cord-010092-uftc8inx 7494 29 , , , cord-010092-uftc8inx 7494 30 mobile mobile JJ cord-010092-uftc8inx 7494 31 ) ) -RRB- cord-010092-uftc8inx 7494 32 type type NN cord-010092-uftc8inx 7494 33 with with IN cord-010092-uftc8inx 7494 34 ARV ARV NNP cord-010092-uftc8inx 7494 35 non non JJ cord-010092-uftc8inx 7494 36 - - NN cord-010092-uftc8inx 7494 37 disclosure disclosure NN cord-010092-uftc8inx 7494 38 . . . cord-010092-uftc8inx 7495 1 Results result NNS cord-010092-uftc8inx 7495 2 : : : cord-010092-uftc8inx 7496 1 During during IN cord-010092-uftc8inx 7496 2 2017 2017 CD cord-010092-uftc8inx 7496 3 , , , cord-010092-uftc8inx 7496 4 1671 1671 CD cord-010092-uftc8inx 7496 5 donors donor NNS cord-010092-uftc8inx 7496 6 tested test VBD cord-010092-uftc8inx 7496 7 HIV HIV NNP cord-010092-uftc8inx 7496 8 - - HYPH cord-010092-uftc8inx 7496 9 positive positive JJ cord-010092-uftc8inx 7496 10 of of IN cord-010092-uftc8inx 7496 11 whom whom WP cord-010092-uftc8inx 7496 12 1315 1315 CD cord-010092-uftc8inx 7496 13 had have VBD cord-010092-uftc8inx 7496 14 samples sample NNS cord-010092-uftc8inx 7496 15 available available JJ cord-010092-uftc8inx 7496 16 that that WDT cord-010092-uftc8inx 7496 17 were be VBD cord-010092-uftc8inx 7496 18 tested test VBN cord-010092-uftc8inx 7496 19 for for IN cord-010092-uftc8inx 7496 20 ARVs arv NNS cord-010092-uftc8inx 7496 21 . . . cord-010092-uftc8inx 7497 1 The the DT cord-010092-uftc8inx 7497 2 overall overall JJ cord-010092-uftc8inx 7497 3 prevalence prevalence NN cord-010092-uftc8inx 7497 4 of of IN cord-010092-uftc8inx 7497 5 undisclosed undisclosed JJ cord-010092-uftc8inx 7497 6 ARV ARV NNP cord-010092-uftc8inx 7497 7 use use NN cord-010092-uftc8inx 7497 8 was be VBD cord-010092-uftc8inx 7497 9 9.3 9.3 CD cord-010092-uftc8inx 7497 10 % % NN cord-010092-uftc8inx 7497 11 ( ( -LRB- cord-010092-uftc8inx 7497 12 n n NN cord-010092-uftc8inx 7497 13 = = SYM cord-010092-uftc8inx 7497 14 122 122 CD cord-010092-uftc8inx 7497 15 ) ) -RRB- cord-010092-uftc8inx 7497 16 with with IN cord-010092-uftc8inx 7497 17 Efavirenz Efavirenz NNP cord-010092-uftc8inx 7497 18 most most RBS cord-010092-uftc8inx 7497 19 frequently frequently RB cord-010092-uftc8inx 7497 20 detected detect VBN cord-010092-uftc8inx 7497 21 ( ( -LRB- cord-010092-uftc8inx 7497 22 115 115 CD cord-010092-uftc8inx 7497 23 ) ) -RRB- cord-010092-uftc8inx 7497 24 , , , cord-010092-uftc8inx 7497 25 followed follow VBN cord-010092-uftc8inx 7497 26 by by IN cord-010092-uftc8inx 7497 27 Lopinavir Lopinavir NNP cord-010092-uftc8inx 7497 28 ( ( -LRB- cord-010092-uftc8inx 7497 29 5 5 CD cord-010092-uftc8inx 7497 30 ) ) -RRB- cord-010092-uftc8inx 7497 31 and and CC cord-010092-uftc8inx 7497 32 Nevirapine Nevirapine NNP cord-010092-uftc8inx 7497 33 ( ( -LRB- cord-010092-uftc8inx 7497 34 2 2 CD cord-010092-uftc8inx 7497 35 ) ) -RRB- cord-010092-uftc8inx 7497 36 . . . cord-010092-uftc8inx 7498 1 Potential potential JJ cord-010092-uftc8inx 7498 2 Elite Elite NNP cord-010092-uftc8inx 7498 3 Controller Controller NNP cord-010092-uftc8inx 7498 4 cases case NNS cord-010092-uftc8inx 7498 5 had have VBD cord-010092-uftc8inx 7498 6 the the DT cord-010092-uftc8inx 7498 7 highest high JJS cord-010092-uftc8inx 7498 8 proportion proportion NN cord-010092-uftc8inx 7498 9 of of IN cord-010092-uftc8inx 7498 10 detectable detectable JJ cord-010092-uftc8inx 7498 11 ARV ARV NNP cord-010092-uftc8inx 7498 12 ( ( -LRB- cord-010092-uftc8inx 7498 13 68/80 68/80 CD cord-010092-uftc8inx 7498 14 ; ; : cord-010092-uftc8inx 7498 15 85 85 CD cord-010092-uftc8inx 7498 16 % % NN cord-010092-uftc8inx 7498 17 ) ) -RRB- cord-010092-uftc8inx 7498 18 ( ( -LRB- cord-010092-uftc8inx 7498 19 P p NN cord-010092-uftc8inx 7498 20 < < XX cord-010092-uftc8inx 7498 21 0.0001 0.0001 CD cord-010092-uftc8inx 7498 22 ) ) -RRB- cord-010092-uftc8inx 7498 23 followed follow VBN cord-010092-uftc8inx 7498 24 by by IN cord-010092-uftc8inx 7498 25 longstanding longstanding JJ cord-010092-uftc8inx 7498 26 ( ( -LRB- cord-010092-uftc8inx 7498 27 37/741 37/741 CD cord-010092-uftc8inx 7498 28 ; ; : cord-010092-uftc8inx 7498 29 4.9 4.9 CD cord-010092-uftc8inx 7498 30 % % NN cord-010092-uftc8inx 7498 31 ) ) -RRB- cord-010092-uftc8inx 7498 32 and and CC cord-010092-uftc8inx 7498 33 recent recent JJ cord-010092-uftc8inx 7498 34 ( ( -LRB- cord-010092-uftc8inx 7498 35 17/366 17/366 CD cord-010092-uftc8inx 7498 36 ; ; : cord-010092-uftc8inx 7498 37 4.6 4.6 CD cord-010092-uftc8inx 7498 38 % % NN cord-010092-uftc8inx 7498 39 ) ) -RRB- cord-010092-uftc8inx 7498 40 infections infection NNS cord-010092-uftc8inx 7498 41 . . . cord-010092-uftc8inx 7499 1 None none NN cord-010092-uftc8inx 7499 2 of of IN cord-010092-uftc8inx 7499 3 82 82 CD cord-010092-uftc8inx 7499 4 acute acute JJ cord-010092-uftc8inx 7499 5 HIV HIV NNP cord-010092-uftc8inx 7499 6 cases case NNS cord-010092-uftc8inx 7499 7 tested test VBD cord-010092-uftc8inx 7499 8 positive positive JJ cord-010092-uftc8inx 7499 9 for for IN cord-010092-uftc8inx 7499 10 ARVs arv NNS cord-010092-uftc8inx 7499 11 . . . cord-010092-uftc8inx 7500 1 There there EX cord-010092-uftc8inx 7500 2 were be VBD cord-010092-uftc8inx 7500 3 no no DT cord-010092-uftc8inx 7500 4 associations association NNS cord-010092-uftc8inx 7500 5 between between IN cord-010092-uftc8inx 7500 6 ARV ARV NNP cord-010092-uftc8inx 7500 7 use use NN cord-010092-uftc8inx 7500 8 and and CC cord-010092-uftc8inx 7500 9 gender gender NN cord-010092-uftc8inx 7500 10 or or CC cord-010092-uftc8inx 7500 11 ethnicity ethnicity NN cord-010092-uftc8inx 7500 12 . . . cord-010092-uftc8inx 7501 1 However however RB cord-010092-uftc8inx 7501 2 , , , cord-010092-uftc8inx 7501 3 older old JJR cord-010092-uftc8inx 7501 4 ( ( -LRB- cord-010092-uftc8inx 7501 5 35 35 CD cord-010092-uftc8inx 7501 6 to to TO cord-010092-uftc8inx 7501 7 64 64 CD cord-010092-uftc8inx 7501 8 years year NNS cord-010092-uftc8inx 7501 9 ) ) -RRB- cord-010092-uftc8inx 7501 10 HIV HIV NNP cord-010092-uftc8inx 7501 11 - - HYPH cord-010092-uftc8inx 7501 12 positive positive JJ cord-010092-uftc8inx 7501 13 donors donor NNS cord-010092-uftc8inx 7501 14 ( ( -LRB- cord-010092-uftc8inx 7501 15 49/305 49/305 CD cord-010092-uftc8inx 7501 16 ; ; : cord-010092-uftc8inx 7501 17 16.1 16.1 CD cord-010092-uftc8inx 7501 18 % % NN cord-010092-uftc8inx 7501 19 ) ) -RRB- cord-010092-uftc8inx 7501 20 were be VBD cord-010092-uftc8inx 7501 21 significantly significantly RB cord-010092-uftc8inx 7501 22 more more RBR cord-010092-uftc8inx 7501 23 likely likely JJ cord-010092-uftc8inx 7501 24 to to TO cord-010092-uftc8inx 7501 25 test test VB cord-010092-uftc8inx 7501 26 positive positive JJ cord-010092-uftc8inx 7501 27 for for IN cord-010092-uftc8inx 7501 28 ARV ARV NNP cord-010092-uftc8inx 7501 29 than than IN cord-010092-uftc8inx 7501 30 younger young JJR cord-010092-uftc8inx 7501 31 ( ( -LRB- cord-010092-uftc8inx 7501 32 15 15 CD cord-010092-uftc8inx 7501 33 to to TO cord-010092-uftc8inx 7501 34 34 34 CD cord-010092-uftc8inx 7501 35 years year NNS cord-010092-uftc8inx 7501 36 ) ) -RRB- cord-010092-uftc8inx 7502 1 donors donor NNS cord-010092-uftc8inx 7502 2 ( ( -LRB- cord-010092-uftc8inx 7502 3 73/1010 73/1010 CD cord-010092-uftc8inx 7502 4 ; ; : cord-010092-uftc8inx 7502 5 7.2 7.2 CD cord-010092-uftc8inx 7502 6 % % NN cord-010092-uftc8inx 7502 7 ) ) -RRB- cord-010092-uftc8inx 7502 8 ( ( -LRB- cord-010092-uftc8inx 7502 9 P p NN cord-010092-uftc8inx 7502 10 < < XX cord-010092-uftc8inx 7502 11 0.0001 0.0001 CD cord-010092-uftc8inx 7502 12 ) ) -RRB- cord-010092-uftc8inx 7502 13 . . . cord-010092-uftc8inx 7503 1 ARV ARV NNP cord-010092-uftc8inx 7503 2 use use NN cord-010092-uftc8inx 7503 3 was be VBD cord-010092-uftc8inx 7503 4 more more RBR cord-010092-uftc8inx 7503 5 frequent frequent JJ cord-010092-uftc8inx 7503 6 among among IN cord-010092-uftc8inx 7503 7 first first JJ cord-010092-uftc8inx 7503 8 time time NN cord-010092-uftc8inx 7503 9 ( ( -LRB- cord-010092-uftc8inx 7503 10 101/ 101/ CD cord-010092-uftc8inx 7503 11 716 716 CD cord-010092-uftc8inx 7503 12 ; ; : cord-010092-uftc8inx 7503 13 14.1 14.1 CD cord-010092-uftc8inx 7503 14 % % NN cord-010092-uftc8inx 7503 15 ) ) -RRB- cord-010092-uftc8inx 7503 16 than than IN cord-010092-uftc8inx 7503 17 in in IN cord-010092-uftc8inx 7503 18 lapsed lapse VBN cord-010092-uftc8inx 7503 19 ( ( -LRB- cord-010092-uftc8inx 7503 20 13/277 13/277 CD cord-010092-uftc8inx 7503 21 ; ; : cord-010092-uftc8inx 7503 22 4.7 4.7 CD cord-010092-uftc8inx 7503 23 % % NN cord-010092-uftc8inx 7503 24 ) ) -RRB- cord-010092-uftc8inx 7503 25 or or CC cord-010092-uftc8inx 7503 26 repeat repeat VB cord-010092-uftc8inx 7503 27 ( ( -LRB- cord-010092-uftc8inx 7503 28 8/322 8/322 CD cord-010092-uftc8inx 7503 29 ; ; : cord-010092-uftc8inx 7503 30 2.5 2.5 CD cord-010092-uftc8inx 7503 31 % % NN cord-010092-uftc8inx 7503 32 ) ) -RRB- cord-010092-uftc8inx 7503 33 donors donor NNS cord-010092-uftc8inx 7503 34 ( ( -LRB- cord-010092-uftc8inx 7503 35 P p NN cord-010092-uftc8inx 7503 36 < < XX cord-010092-uftc8inx 7503 37 0.0001 0.0001 CD cord-010092-uftc8inx 7503 38 ) ) -RRB- cord-010092-uftc8inx 7503 39 . . . cord-010092-uftc8inx 7504 1 Donors donor NNS cord-010092-uftc8inx 7504 2 at at IN cord-010092-uftc8inx 7504 3 mobile mobile JJ cord-010092-uftc8inx 7504 4 clinics clinic NNS cord-010092-uftc8inx 7504 5 had have VBD cord-010092-uftc8inx 7504 6 significantly significantly RB cord-010092-uftc8inx 7504 7 higher high JJR cord-010092-uftc8inx 7504 8 ARV ARV NNP cord-010092-uftc8inx 7504 9 non non JJ cord-010092-uftc8inx 7504 10 - - NN cord-010092-uftc8inx 7504 11 disclosure disclosure NN cord-010092-uftc8inx 7504 12 than than IN cord-010092-uftc8inx 7504 13 donors donor NNS cord-010092-uftc8inx 7504 14 at at IN cord-010092-uftc8inx 7504 15 fixed fix VBN cord-010092-uftc8inx 7504 16 sites site NNS cord-010092-uftc8inx 7504 17 ( ( -LRB- cord-010092-uftc8inx 7504 18 10.4 10.4 CD cord-010092-uftc8inx 7504 19 % % NN cord-010092-uftc8inx 7504 20 vs vs IN cord-010092-uftc8inx 7504 21 5.0 5.0 CD cord-010092-uftc8inx 7504 22 % % NN cord-010092-uftc8inx 7504 23 ; ; : cord-010092-uftc8inx 7504 24 P p NN cord-010092-uftc8inx 7504 25 = = SYM cord-010092-uftc8inx 7504 26 0.0051 0.0051 CD cord-010092-uftc8inx 7504 27 ) ) -RRB- cord-010092-uftc8inx 7504 28 . . . cord-010092-uftc8inx 7505 1 Summary Summary NNP cord-010092-uftc8inx 7505 2 / / SYM cord-010092-uftc8inx 7505 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 7505 4 : : : cord-010092-uftc8inx 7506 1 The the DT cord-010092-uftc8inx 7506 2 9.3 9.3 CD cord-010092-uftc8inx 7506 3 % % NN cord-010092-uftc8inx 7506 4 prevalence prevalence NN cord-010092-uftc8inx 7506 5 of of IN cord-010092-uftc8inx 7506 6 undisclosed undisclosed JJ cord-010092-uftc8inx 7506 7 infection infection NN cord-010092-uftc8inx 7506 8 and and CC cord-010092-uftc8inx 7506 9 ARV ARV NNP cord-010092-uftc8inx 7506 10 use use NN cord-010092-uftc8inx 7506 11 among among IN cord-010092-uftc8inx 7506 12 HIV HIV NNP cord-010092-uftc8inx 7506 13 - - HYPH cord-010092-uftc8inx 7506 14 positive positive JJ cord-010092-uftc8inx 7506 15 South south JJ cord-010092-uftc8inx 7506 16 African african JJ cord-010092-uftc8inx 7506 17 blood blood NN cord-010092-uftc8inx 7506 18 donors donor NNS cord-010092-uftc8inx 7506 19 is be VBZ cord-010092-uftc8inx 7506 20 alarming alarming JJ cord-010092-uftc8inx 7506 21 . . . cord-010092-uftc8inx 7507 1 Higher high JJR cord-010092-uftc8inx 7507 2 rates rate NNS cord-010092-uftc8inx 7507 3 of of IN cord-010092-uftc8inx 7507 4 nondisclosure nondisclosure NN cord-010092-uftc8inx 7507 5 among among IN cord-010092-uftc8inx 7507 6 first first JJ cord-010092-uftc8inx 7507 7 - - HYPH cord-010092-uftc8inx 7507 8 time time NN cord-010092-uftc8inx 7507 9 donors donor NNS cord-010092-uftc8inx 7507 10 was be VBD cord-010092-uftc8inx 7507 11 expected expect VBN cord-010092-uftc8inx 7507 12 , , , cord-010092-uftc8inx 7507 13 but but CC cord-010092-uftc8inx 7507 14 non non JJ cord-010092-uftc8inx 7507 15 - - NN cord-010092-uftc8inx 7507 16 disclosure disclosure NN cord-010092-uftc8inx 7507 17 among among IN cord-010092-uftc8inx 7507 18 repeat repeat NN cord-010092-uftc8inx 7507 19 and and CC cord-010092-uftc8inx 7507 20 lapsed lapse VBN cord-010092-uftc8inx 7507 21 donors donor NNS cord-010092-uftc8inx 7507 22 suggests suggest VBZ cord-010092-uftc8inx 7507 23 failure failure NN cord-010092-uftc8inx 7507 24 in in IN cord-010092-uftc8inx 7507 25 donor donor NN cord-010092-uftc8inx 7507 26 education education NN cord-010092-uftc8inx 7507 27 and and CC cord-010092-uftc8inx 7507 28 assessment assessment NN cord-010092-uftc8inx 7507 29 . . . cord-010092-uftc8inx 7508 1 The the DT cord-010092-uftc8inx 7508 2 4.7 4.7 CD cord-010092-uftc8inx 7508 3 % % NN cord-010092-uftc8inx 7508 4 prevalence prevalence NN cord-010092-uftc8inx 7508 5 among among IN cord-010092-uftc8inx 7508 6 concordant concordant JJ cord-010092-uftc8inx 7508 7 Ab+/RNA+ Ab+/RNA+ NNP cord-010092-uftc8inx 7508 8 cases case NNS cord-010092-uftc8inx 7508 9 may may MD cord-010092-uftc8inx 7508 10 suggest suggest VB cord-010092-uftc8inx 7508 11 sub sub JJ cord-010092-uftc8inx 7508 12 - - JJ cord-010092-uftc8inx 7508 13 optimal optimal JJ cord-010092-uftc8inx 7508 14 viral viral JJ cord-010092-uftc8inx 7508 15 suppression suppression NN cord-010092-uftc8inx 7508 16 . . . cord-010092-uftc8inx 7509 1 Lack lack NN cord-010092-uftc8inx 7509 2 of of IN cord-010092-uftc8inx 7509 3 detection detection NN cord-010092-uftc8inx 7509 4 of of IN cord-010092-uftc8inx 7509 5 ARVs arv NNS cord-010092-uftc8inx 7509 6 in in IN cord-010092-uftc8inx 7509 7 acute acute JJ cord-010092-uftc8inx 7509 8 cases case NNS cord-010092-uftc8inx 7509 9 should should MD cord-010092-uftc8inx 7509 10 be be VB cord-010092-uftc8inx 7509 11 qualified qualified JJ cord-010092-uftc8inx 7509 12 because because IN cord-010092-uftc8inx 7509 13 the the DT cord-010092-uftc8inx 7509 14 samples sample NNS cord-010092-uftc8inx 7509 15 were be VBD cord-010092-uftc8inx 7509 16 not not RB cord-010092-uftc8inx 7509 17 tested test VBN cord-010092-uftc8inx 7509 18 for for IN cord-010092-uftc8inx 7509 19 Tenofovir Tenofovir NNP cord-010092-uftc8inx 7509 20 , , , cord-010092-uftc8inx 7509 21 the the DT cord-010092-uftc8inx 7509 22 most most RBS cord-010092-uftc8inx 7509 23 common common JJ cord-010092-uftc8inx 7509 24 drug drug NN cord-010092-uftc8inx 7509 25 used use VBN cord-010092-uftc8inx 7509 26 in in IN cord-010092-uftc8inx 7509 27 pre pre JJ cord-010092-uftc8inx 7509 28 - - JJ cord-010092-uftc8inx 7509 29 exposure exposure JJ cord-010092-uftc8inx 7509 30 prophylaxis prophylaxis NN cord-010092-uftc8inx 7509 31 . . . cord-010092-uftc8inx 7510 1 Donor donor NN cord-010092-uftc8inx 7510 2 motivation motivation NN cord-010092-uftc8inx 7510 3 for for IN cord-010092-uftc8inx 7510 4 non non JJ cord-010092-uftc8inx 7510 5 - - JJ cord-010092-uftc8inx 7510 6 disclosure disclosure NN cord-010092-uftc8inx 7510 7 of of IN cord-010092-uftc8inx 7510 8 known know VBN cord-010092-uftc8inx 7510 9 HIV HIV NNP cord-010092-uftc8inx 7510 10 infection infection NN cord-010092-uftc8inx 7510 11 and and CC cord-010092-uftc8inx 7510 12 ARV ARV NNP cord-010092-uftc8inx 7510 13 use use NN cord-010092-uftc8inx 7510 14 needs need VBZ cord-010092-uftc8inx 7510 15 further further JJ cord-010092-uftc8inx 7510 16 investigation investigation NN cord-010092-uftc8inx 7510 17 , , , cord-010092-uftc8inx 7510 18 since since IN cord-010092-uftc8inx 7510 19 early early JJ cord-010092-uftc8inx 7510 20 ARV ARV NNP cord-010092-uftc8inx 7510 21 initiation initiation NN cord-010092-uftc8inx 7510 22 or or CC cord-010092-uftc8inx 7510 23 infection infection NN cord-010092-uftc8inx 7510 24 while while IN cord-010092-uftc8inx 7510 25 on on IN cord-010092-uftc8inx 7510 26 PrEP prep NN cord-010092-uftc8inx 7510 27 could could MD cord-010092-uftc8inx 7510 28 lead lead VB cord-010092-uftc8inx 7510 29 to to IN cord-010092-uftc8inx 7510 30 low low JJ cord-010092-uftc8inx 7510 31 Ab Ab NNP cord-010092-uftc8inx 7510 32 and and CC cord-010092-uftc8inx 7510 33 RNA RNA NNP cord-010092-uftc8inx 7510 34 levels level NNS cord-010092-uftc8inx 7510 35 , , , cord-010092-uftc8inx 7510 36 failure failure NN cord-010092-uftc8inx 7510 37 to to TO cord-010092-uftc8inx 7510 38 detect detect VB cord-010092-uftc8inx 7510 39 HIV HIV NNP cord-010092-uftc8inx 7510 40 - - HYPH cord-010092-uftc8inx 7510 41 infected infect VBN cord-010092-uftc8inx 7510 42 donations donation NNS cord-010092-uftc8inx 7510 43 and and CC cord-010092-uftc8inx 7510 44 transfusion transfusion NN cord-010092-uftc8inx 7510 45 - - HYPH cord-010092-uftc8inx 7510 46 transmission transmission NN cord-010092-uftc8inx 7510 47 of of IN cord-010092-uftc8inx 7510 48 HIV HIV NNP cord-010092-uftc8inx 7510 49 . . . cord-010092-uftc8inx 7511 1 Blood Blood NNP cord-010092-uftc8inx 7511 2 Bank Bank NNP cord-010092-uftc8inx 7511 3 , , , cord-010092-uftc8inx 7511 4 Rotary Rotary NNP cord-010092-uftc8inx 7511 5 Blood Blood NNP cord-010092-uftc8inx 7511 6 Bank Bank NNP cord-010092-uftc8inx 7511 7 , , , cord-010092-uftc8inx 7511 8 New New NNP cord-010092-uftc8inx 7511 9 Delhi Delhi NNP cord-010092-uftc8inx 7511 10 , , , cord-010092-uftc8inx 7511 11 India India NNP cord-010092-uftc8inx 7511 12 Background Background NNP cord-010092-uftc8inx 7511 13 : : : cord-010092-uftc8inx 7512 1 Voluntary voluntary JJ cord-010092-uftc8inx 7512 2 blood blood NN cord-010092-uftc8inx 7512 3 donation donation NN cord-010092-uftc8inx 7512 4 ensures ensure VBZ cord-010092-uftc8inx 7512 5 safe safe JJ cord-010092-uftc8inx 7512 6 blood blood NN cord-010092-uftc8inx 7512 7 transfusion transfusion NN cord-010092-uftc8inx 7512 8 . . . cord-010092-uftc8inx 7513 1 Careful careful JJ cord-010092-uftc8inx 7513 2 blood blood NN cord-010092-uftc8inx 7513 3 donor donor NN cord-010092-uftc8inx 7513 4 selection selection NN cord-010092-uftc8inx 7513 5 is be VBZ cord-010092-uftc8inx 7513 6 of of IN cord-010092-uftc8inx 7513 7 importance importance NN cord-010092-uftc8inx 7513 8 to to TO cord-010092-uftc8inx 7513 9 provide provide VB cord-010092-uftc8inx 7513 10 safe safe JJ cord-010092-uftc8inx 7513 11 blood blood NN cord-010092-uftc8inx 7513 12 to to IN cord-010092-uftc8inx 7513 13 patients patient NNS cord-010092-uftc8inx 7513 14 , , , cord-010092-uftc8inx 7513 15 although although IN cord-010092-uftc8inx 7513 16 new new JJ cord-010092-uftc8inx 7513 17 methodologies methodology NNS cord-010092-uftc8inx 7513 18 have have VBP cord-010092-uftc8inx 7513 19 also also RB cord-010092-uftc8inx 7513 20 been be VBN cord-010092-uftc8inx 7513 21 adopted adopt VBN cord-010092-uftc8inx 7513 22 by by IN cord-010092-uftc8inx 7513 23 blood blood NN cord-010092-uftc8inx 7513 24 centers center NNS cord-010092-uftc8inx 7513 25 for for IN cord-010092-uftc8inx 7513 26 blood blood NN cord-010092-uftc8inx 7513 27 safety safety NN cord-010092-uftc8inx 7513 28 and and CC cord-010092-uftc8inx 7513 29 to to TO cord-010092-uftc8inx 7513 30 minimize minimize VB cord-010092-uftc8inx 7513 31 risk risk NN cord-010092-uftc8inx 7513 32 of of IN cord-010092-uftc8inx 7513 33 transmitting transmit VBG cord-010092-uftc8inx 7513 34 infections infection NNS cord-010092-uftc8inx 7513 35 through through IN cord-010092-uftc8inx 7513 36 blood blood NN cord-010092-uftc8inx 7513 37 transfusion transfusion NN cord-010092-uftc8inx 7513 38 . . . cord-010092-uftc8inx 7514 1 The the DT cord-010092-uftc8inx 7514 2 quality quality NN cord-010092-uftc8inx 7514 3 and and CC cord-010092-uftc8inx 7514 4 the the DT cord-010092-uftc8inx 7514 5 availability availability NN cord-010092-uftc8inx 7514 6 of of IN cord-010092-uftc8inx 7514 7 blood blood NN cord-010092-uftc8inx 7514 8 components component NNS cord-010092-uftc8inx 7514 9 depend depend VBP cord-010092-uftc8inx 7514 10 on on IN cord-010092-uftc8inx 7514 11 the the DT cord-010092-uftc8inx 7514 12 willingness willingness NN cord-010092-uftc8inx 7514 13 to to TO cord-010092-uftc8inx 7514 14 donate donate VB cord-010092-uftc8inx 7514 15 and and CC cord-010092-uftc8inx 7514 16 reliability reliability NN cord-010092-uftc8inx 7514 17 of of IN cord-010092-uftc8inx 7514 18 the the DT cord-010092-uftc8inx 7514 19 information information NN cord-010092-uftc8inx 7514 20 given give VBN cord-010092-uftc8inx 7514 21 by by IN cord-010092-uftc8inx 7514 22 the the DT cord-010092-uftc8inx 7514 23 donors donor NNS cord-010092-uftc8inx 7514 24 about about IN cord-010092-uftc8inx 7514 25 their -PRON- PRP$ cord-010092-uftc8inx 7514 26 own own JJ cord-010092-uftc8inx 7514 27 health health NN cord-010092-uftc8inx 7514 28 , , , cord-010092-uftc8inx 7514 29 including include VBG cord-010092-uftc8inx 7514 30 risk risk NN cord-010092-uftc8inx 7514 31 behaviour behaviour NN cord-010092-uftc8inx 7514 32 . . . cord-010092-uftc8inx 7515 1 Blood blood NN cord-010092-uftc8inx 7515 2 donor donor NN cord-010092-uftc8inx 7515 3 history history NN cord-010092-uftc8inx 7515 4 questionnaire questionnaire NN cord-010092-uftc8inx 7515 5 is be VBZ cord-010092-uftc8inx 7515 6 designed design VBN cord-010092-uftc8inx 7515 7 to to TO cord-010092-uftc8inx 7515 8 evaluate evaluate VB cord-010092-uftc8inx 7515 9 donor donor NN cord-010092-uftc8inx 7515 10 's 's POS cord-010092-uftc8inx 7515 11 history history NN cord-010092-uftc8inx 7515 12 in in IN cord-010092-uftc8inx 7515 13 accordance accordance NN cord-010092-uftc8inx 7515 14 with with IN cord-010092-uftc8inx 7515 15 the the DT cord-010092-uftc8inx 7515 16 guidelines guideline NNS cord-010092-uftc8inx 7515 17 laid lay VBN cord-010092-uftc8inx 7515 18 down down RP cord-010092-uftc8inx 7515 19 by by IN cord-010092-uftc8inx 7515 20 the the DT cord-010092-uftc8inx 7515 21 FDA FDA NNP cord-010092-uftc8inx 7515 22 . . . cord-010092-uftc8inx 7516 1 Donors donor NNS cord-010092-uftc8inx 7516 2 , , , cord-010092-uftc8inx 7516 3 once once RB cord-010092-uftc8inx 7516 4 deferred defer VBN cord-010092-uftc8inx 7516 5 by by IN cord-010092-uftc8inx 7516 6 the the DT cord-010092-uftc8inx 7516 7 blood blood NN cord-010092-uftc8inx 7516 8 bank bank NN cord-010092-uftc8inx 7516 9 , , , cord-010092-uftc8inx 7516 10 will will MD cord-010092-uftc8inx 7516 11 be be VB cord-010092-uftc8inx 7516 12 less less RBR cord-010092-uftc8inx 7516 13 motivated motivated JJ cord-010092-uftc8inx 7516 14 to to TO cord-010092-uftc8inx 7516 15 return return VB cord-010092-uftc8inx 7516 16 for for IN cord-010092-uftc8inx 7516 17 donation donation NN cord-010092-uftc8inx 7516 18 if if IN cord-010092-uftc8inx 7516 19 he -PRON- PRP cord-010092-uftc8inx 7516 20 is be VBZ cord-010092-uftc8inx 7516 21 not not RB cord-010092-uftc8inx 7516 22 counseled counsel VBN cord-010092-uftc8inx 7516 23 effectively effectively RB cord-010092-uftc8inx 7516 24 . . . cord-010092-uftc8inx 7517 1 It -PRON- PRP cord-010092-uftc8inx 7517 2 is be VBZ cord-010092-uftc8inx 7517 3 important important JJ cord-010092-uftc8inx 7517 4 to to TO cord-010092-uftc8inx 7517 5 reduce reduce VB cord-010092-uftc8inx 7517 6 the the DT cord-010092-uftc8inx 7517 7 number number NN cord-010092-uftc8inx 7517 8 of of IN cord-010092-uftc8inx 7517 9 deferrals deferral NNS cord-010092-uftc8inx 7517 10 by by IN cord-010092-uftc8inx 7517 11 good good JJ cord-010092-uftc8inx 7517 12 donor donor NN cord-010092-uftc8inx 7517 13 comprehension comprehension NN cord-010092-uftc8inx 7517 14 and and CC cord-010092-uftc8inx 7517 15 the the DT cord-010092-uftc8inx 7517 16 centre centre NN cord-010092-uftc8inx 7517 17 should should MD cord-010092-uftc8inx 7517 18 have have VB cord-010092-uftc8inx 7517 19 a a DT cord-010092-uftc8inx 7517 20 mechanism mechanism NN cord-010092-uftc8inx 7517 21 to to TO cord-010092-uftc8inx 7517 22 recall recall VB cord-010092-uftc8inx 7517 23 temporarily temporarily RB cord-010092-uftc8inx 7517 24 deferred defer VBN cord-010092-uftc8inx 7517 25 donors donor NNS cord-010092-uftc8inx 7518 1 Aims aim VBZ cord-010092-uftc8inx 7518 2 : : : cord-010092-uftc8inx 7518 3 The the DT cord-010092-uftc8inx 7518 4 aim aim NN cord-010092-uftc8inx 7518 5 of of IN cord-010092-uftc8inx 7518 6 the the DT cord-010092-uftc8inx 7518 7 study study NN cord-010092-uftc8inx 7518 8 is be VBZ cord-010092-uftc8inx 7518 9 to to TO cord-010092-uftc8inx 7518 10 analyse analyse VB cord-010092-uftc8inx 7518 11 donor donor NN cord-010092-uftc8inx 7518 12 history history NN cord-010092-uftc8inx 7518 13 and and CC cord-010092-uftc8inx 7518 14 test test NN cord-010092-uftc8inx 7518 15 results result NNS cord-010092-uftc8inx 7518 16 of of IN cord-010092-uftc8inx 7518 17 those those DT cord-010092-uftc8inx 7518 18 who who WP cord-010092-uftc8inx 7518 19 donated donate VBD cord-010092-uftc8inx 7518 20 blood blood NN cord-010092-uftc8inx 7518 21 with with IN cord-010092-uftc8inx 7518 22 past past JJ cord-010092-uftc8inx 7518 23 history history NN cord-010092-uftc8inx 7518 24 of of IN cord-010092-uftc8inx 7518 25 jaundice jaundice NN cord-010092-uftc8inx 7518 26 . . . cord-010092-uftc8inx 7519 1 Based base VBN cord-010092-uftc8inx 7519 2 on on IN cord-010092-uftc8inx 7519 3 their -PRON- PRP$ cord-010092-uftc8inx 7519 4 history history NN cord-010092-uftc8inx 7519 5 which which WDT cord-010092-uftc8inx 7519 6 suggested suggest VBD cord-010092-uftc8inx 7519 7 the the DT cord-010092-uftc8inx 7519 8 type type NN cord-010092-uftc8inx 7519 9 of of IN cord-010092-uftc8inx 7519 10 viral viral JJ cord-010092-uftc8inx 7519 11 infection infection NN cord-010092-uftc8inx 7519 12 they -PRON- PRP cord-010092-uftc8inx 7519 13 had have VBD cord-010092-uftc8inx 7519 14 , , , cord-010092-uftc8inx 7519 15 these these DT cord-010092-uftc8inx 7519 16 donors donor NNS cord-010092-uftc8inx 7519 17 were be VBD cord-010092-uftc8inx 7519 18 accepted accept VBN cord-010092-uftc8inx 7519 19 or or CC cord-010092-uftc8inx 7519 20 deferred defer VBN cord-010092-uftc8inx 7519 21 . . . cord-010092-uftc8inx 7520 1 Data datum NNS cord-010092-uftc8inx 7520 2 was be VBD cord-010092-uftc8inx 7520 3 collected collect VBN cord-010092-uftc8inx 7520 4 from from IN cord-010092-uftc8inx 7520 5 voluntary voluntary JJ cord-010092-uftc8inx 7520 6 blood blood NN cord-010092-uftc8inx 7520 7 donors donor NNS cord-010092-uftc8inx 7520 8 who who WP cord-010092-uftc8inx 7520 9 were be VBD cord-010092-uftc8inx 7520 10 screened screen VBN cord-010092-uftc8inx 7520 11 for for IN cord-010092-uftc8inx 7520 12 blood blood NN cord-010092-uftc8inx 7520 13 donation donation NN cord-010092-uftc8inx 7520 14 in in IN cord-010092-uftc8inx 7520 15 the the DT cord-010092-uftc8inx 7520 16 year year NN cord-010092-uftc8inx 7520 17 2018 2018 CD cord-010092-uftc8inx 7520 18 . . . cord-010092-uftc8inx 7521 1 Methods method NNS cord-010092-uftc8inx 7521 2 : : : cord-010092-uftc8inx 7521 3 In in IN cord-010092-uftc8inx 7521 4 this this DT cord-010092-uftc8inx 7521 5 study study NN cord-010092-uftc8inx 7521 6 , , , cord-010092-uftc8inx 7521 7 donor donor NN cord-010092-uftc8inx 7521 8 history history NN cord-010092-uftc8inx 7521 9 was be VBD cord-010092-uftc8inx 7521 10 analysed analyse VBN cord-010092-uftc8inx 7521 11 with with IN cord-010092-uftc8inx 7521 12 reference reference NN cord-010092-uftc8inx 7521 13 to to IN cord-010092-uftc8inx 7521 14 history history NN cord-010092-uftc8inx 7521 15 of of IN cord-010092-uftc8inx 7521 16 jaundice jaundice NN cord-010092-uftc8inx 7521 17 . . . cord-010092-uftc8inx 7522 1 Jaundice jaundice NN cord-010092-uftc8inx 7522 2 in in IN cord-010092-uftc8inx 7522 3 donors donor NNS cord-010092-uftc8inx 7522 4 after after IN cord-010092-uftc8inx 7522 5 the the DT cord-010092-uftc8inx 7522 6 age age NN cord-010092-uftc8inx 7522 7 of of IN cord-010092-uftc8inx 7522 8 11 11 CD cord-010092-uftc8inx 7522 9 yrs yr NNS cord-010092-uftc8inx 7522 10 , , , cord-010092-uftc8inx 7522 11 history history NN cord-010092-uftc8inx 7522 12 of of IN cord-010092-uftc8inx 7522 13 surgery surgery NN cord-010092-uftc8inx 7522 14 , , , cord-010092-uftc8inx 7522 15 blood blood NN cord-010092-uftc8inx 7522 16 transfusion transfusion NN cord-010092-uftc8inx 7522 17 , , , cord-010092-uftc8inx 7522 18 body body NN cord-010092-uftc8inx 7522 19 tattoos tattoo NNS cord-010092-uftc8inx 7522 20 and and CC cord-010092-uftc8inx 7522 21 acupuncture acupuncture NN cord-010092-uftc8inx 7522 22 treatment treatment NN cord-010092-uftc8inx 7522 23 within within IN cord-010092-uftc8inx 7522 24 past past JJ cord-010092-uftc8inx 7522 25 one one CD cord-010092-uftc8inx 7522 26 year year NN cord-010092-uftc8inx 7522 27 of of IN cord-010092-uftc8inx 7522 28 donation donation NN cord-010092-uftc8inx 7522 29 , , , cord-010092-uftc8inx 7522 30 history history NN cord-010092-uftc8inx 7522 31 of of IN cord-010092-uftc8inx 7522 32 multiple multiple JJ cord-010092-uftc8inx 7522 33 sex sex NN cord-010092-uftc8inx 7522 34 partners partner NNS cord-010092-uftc8inx 7522 35 and and CC cord-010092-uftc8inx 7522 36 related related JJ cord-010092-uftc8inx 7522 37 history history NN cord-010092-uftc8inx 7522 38 and and CC cord-010092-uftc8inx 7522 39 intravenous intravenous JJ cord-010092-uftc8inx 7522 40 drug drug NN cord-010092-uftc8inx 7522 41 abuse abuse NN cord-010092-uftc8inx 7522 42 history history NN cord-010092-uftc8inx 7522 43 was be VBD cord-010092-uftc8inx 7522 44 taken take VBN cord-010092-uftc8inx 7522 45 into into IN cord-010092-uftc8inx 7522 46 consideration consideration NN cord-010092-uftc8inx 7522 47 . . . cord-010092-uftc8inx 7523 1 Donors donor NNS cord-010092-uftc8inx 7523 2 who who WP cord-010092-uftc8inx 7523 3 revealed reveal VBD cord-010092-uftc8inx 7523 4 past past IN cord-010092-uftc8inx 7523 5 history history NN cord-010092-uftc8inx 7523 6 of of IN cord-010092-uftc8inx 7523 7 jaundice jaundice NN cord-010092-uftc8inx 7523 8 were be VBD cord-010092-uftc8inx 7523 9 asked ask VBN cord-010092-uftc8inx 7523 10 in in IN cord-010092-uftc8inx 7523 11 detail detail NN cord-010092-uftc8inx 7523 12 about about IN cord-010092-uftc8inx 7523 13 their -PRON- PRP$ cord-010092-uftc8inx 7523 14 illness illness NN cord-010092-uftc8inx 7523 15 and and CC cord-010092-uftc8inx 7523 16 recovery recovery NN cord-010092-uftc8inx 7523 17 . . . cord-010092-uftc8inx 7524 1 Blood blood NN cord-010092-uftc8inx 7524 2 was be VBD cord-010092-uftc8inx 7524 3 donated donate VBN cord-010092-uftc8inx 7524 4 by by IN cord-010092-uftc8inx 7524 5 donors donor NNS cord-010092-uftc8inx 7524 6 from from IN cord-010092-uftc8inx 7524 7 whom whom WP cord-010092-uftc8inx 7524 8 the the DT cord-010092-uftc8inx 7524 9 history history NN cord-010092-uftc8inx 7524 10 of of IN cord-010092-uftc8inx 7524 11 jaundice jaundice NN cord-010092-uftc8inx 7524 12 was be VBD cord-010092-uftc8inx 7524 13 elicited elicit VBN cord-010092-uftc8inx 7524 14 and and CC cord-010092-uftc8inx 7524 15 it -PRON- PRP cord-010092-uftc8inx 7524 16 was be VBD cord-010092-uftc8inx 7524 17 understood understand VBN cord-010092-uftc8inx 7524 18 that that IN cord-010092-uftc8inx 7524 19 the the DT cord-010092-uftc8inx 7524 20 type type NN cord-010092-uftc8inx 7524 21 of of IN cord-010092-uftc8inx 7524 22 virus virus NN cord-010092-uftc8inx 7524 23 which which WDT cord-010092-uftc8inx 7524 24 caused cause VBD cord-010092-uftc8inx 7524 25 jaundice jaundice NN cord-010092-uftc8inx 7524 26 was be VBD cord-010092-uftc8inx 7524 27 not not RB cord-010092-uftc8inx 7524 28 Hepatitis Hepatitis NNP cord-010092-uftc8inx 7524 29 B B NNP cord-010092-uftc8inx 7524 30 or or CC cord-010092-uftc8inx 7524 31 C. C. NNP cord-010092-uftc8inx 7524 32 Those those DT cord-010092-uftc8inx 7524 33 who who WP cord-010092-uftc8inx 7524 34 could could MD cord-010092-uftc8inx 7524 35 not not RB cord-010092-uftc8inx 7524 36 give give VB cord-010092-uftc8inx 7524 37 the the DT cord-010092-uftc8inx 7524 38 correct correct JJ cord-010092-uftc8inx 7524 39 history history NN cord-010092-uftc8inx 7524 40 or or CC cord-010092-uftc8inx 7524 41 were be VBD cord-010092-uftc8inx 7524 42 not not RB cord-010092-uftc8inx 7524 43 sure sure JJ cord-010092-uftc8inx 7524 44 of of IN cord-010092-uftc8inx 7524 45 the the DT cord-010092-uftc8inx 7524 46 cause cause NN cord-010092-uftc8inx 7524 47 of of IN cord-010092-uftc8inx 7524 48 hepatitis hepatitis NN cord-010092-uftc8inx 7524 49 , , , cord-010092-uftc8inx 7524 50 those those DT cord-010092-uftc8inx 7524 51 individuals individual NNS cord-010092-uftc8inx 7524 52 were be VBD cord-010092-uftc8inx 7524 53 deferred defer VBN cord-010092-uftc8inx 7524 54 . . . cord-010092-uftc8inx 7525 1 Aims aim VBZ cord-010092-uftc8inx 7525 2 : : : cord-010092-uftc8inx 7526 1 To to TO cord-010092-uftc8inx 7526 2 assess assess VB cord-010092-uftc8inx 7526 3 the the DT cord-010092-uftc8inx 7526 4 performance performance NN cord-010092-uftc8inx 7526 5 of of IN cord-010092-uftc8inx 7526 6 this this DT cord-010092-uftc8inx 7526 7 follow follow NN cord-010092-uftc8inx 7526 8 - - HYPH cord-010092-uftc8inx 7526 9 up up NN cord-010092-uftc8inx 7526 10 program program NN cord-010092-uftc8inx 7526 11 in in IN cord-010092-uftc8inx 7526 12 terms term NNS cord-010092-uftc8inx 7526 13 of of IN cord-010092-uftc8inx 7526 14 donor donor NN cord-010092-uftc8inx 7526 15 participations participation NNS cord-010092-uftc8inx 7526 16 , , , cord-010092-uftc8inx 7526 17 successful successful JJ cord-010092-uftc8inx 7526 18 confirmed confirm VBD cord-010092-uftc8inx 7526 19 positivity positivity NN cord-010092-uftc8inx 7526 20 rates rate NNS cord-010092-uftc8inx 7526 21 , , , cord-010092-uftc8inx 7526 22 and and CC cord-010092-uftc8inx 7526 23 potential potential JJ cord-010092-uftc8inx 7526 24 reentry reentry NN cord-010092-uftc8inx 7526 25 rates rate NNS cord-010092-uftc8inx 7526 26 . . . cord-010092-uftc8inx 7527 1 Methods method NNS cord-010092-uftc8inx 7527 2 : : : cord-010092-uftc8inx 7527 3 Eligible eligible JJ cord-010092-uftc8inx 7527 4 donors donor NNS cord-010092-uftc8inx 7527 5 were be VBD cord-010092-uftc8inx 7527 6 tested test VBN cord-010092-uftc8inx 7527 7 for for IN cord-010092-uftc8inx 7527 8 HBsAg hbsag ADD cord-010092-uftc8inx 7527 9 , , , cord-010092-uftc8inx 7527 10 HCVAb HCVAb NNS cord-010092-uftc8inx 7527 11 , , , cord-010092-uftc8inx 7527 12 HIVAb HIVAb NNP cord-010092-uftc8inx 7527 13 / / SYM cord-010092-uftc8inx 7527 14 Ag Ag NNP cord-010092-uftc8inx 7527 15 , , , cord-010092-uftc8inx 7527 16 and and CC cord-010092-uftc8inx 7527 17 TPAb TPAb NNS cord-010092-uftc8inx 7527 18 with with IN cord-010092-uftc8inx 7527 19 two two CD cord-010092-uftc8inx 7527 20 EIAs eia NNS cord-010092-uftc8inx 7527 21 for for IN cord-010092-uftc8inx 7527 22 each each DT cord-010092-uftc8inx 7527 23 marker marker NN cord-010092-uftc8inx 7527 24 . . . cord-010092-uftc8inx 7528 1 Samples sample NNS cord-010092-uftc8inx 7528 2 reactive reactive JJ cord-010092-uftc8inx 7528 3 with with IN cord-010092-uftc8inx 7528 4 at at RB cord-010092-uftc8inx 7528 5 least least RBS cord-010092-uftc8inx 7528 6 one one CD cord-010092-uftc8inx 7528 7 assay assay NN cord-010092-uftc8inx 7528 8 were be VBD cord-010092-uftc8inx 7528 9 tested test VBN cord-010092-uftc8inx 7528 10 further further RB cord-010092-uftc8inx 7528 11 with with IN cord-010092-uftc8inx 7528 12 electro electro JJ cord-010092-uftc8inx 7528 13 - - HYPH cord-010092-uftc8inx 7528 14 chemiluminescence chemiluminescence NN cord-010092-uftc8inx 7528 15 assay assay NN cord-010092-uftc8inx 7528 16 ( ( -LRB- cord-010092-uftc8inx 7528 17 ECA ECA NNP cord-010092-uftc8inx 7528 18 ) ) -RRB- cord-010092-uftc8inx 7528 19 and and CC cord-010092-uftc8inx 7528 20 reactive reactive JJ cord-010092-uftc8inx 7528 21 samples sample NNS cord-010092-uftc8inx 7528 22 were be VBD cord-010092-uftc8inx 7528 23 considered consider VBN cord-010092-uftc8inx 7528 24 repeated repeat VBN cord-010092-uftc8inx 7528 25 reactive reactive JJ cord-010092-uftc8inx 7528 26 ( ( -LRB- cord-010092-uftc8inx 7528 27 RR RR NNP cord-010092-uftc8inx 7528 28 ) ) -RRB- cord-010092-uftc8inx 7528 29 . . . cord-010092-uftc8inx 7529 1 TPAb TPAb NNP cord-010092-uftc8inx 7529 2 reactive reactive JJ cord-010092-uftc8inx 7529 3 donations donation NNS cord-010092-uftc8inx 7529 4 were be VBD cord-010092-uftc8inx 7529 5 re re VBN cord-010092-uftc8inx 7529 6 - - VBN cord-010092-uftc8inx 7529 7 tested test VBN cord-010092-uftc8inx 7529 8 with with IN cord-010092-uftc8inx 7529 9 particle particle NN cord-010092-uftc8inx 7529 10 agglutination agglutination NN cord-010092-uftc8inx 7529 11 assay assay NN cord-010092-uftc8inx 7529 12 ( ( -LRB- cord-010092-uftc8inx 7529 13 TPPA TPPA NNP cord-010092-uftc8inx 7529 14 ) ) -RRB- cord-010092-uftc8inx 7529 15 . . . cord-010092-uftc8inx 7530 1 Samples sample NNS cord-010092-uftc8inx 7530 2 ECA ECA NNP cord-010092-uftc8inx 7530 3 or or CC cord-010092-uftc8inx 7530 4 TPPA tppa JJ cord-010092-uftc8inx 7530 5 non non JJ cord-010092-uftc8inx 7530 6 - - JJ cord-010092-uftc8inx 7530 7 reactive reactive JJ cord-010092-uftc8inx 7530 8 were be VBD cord-010092-uftc8inx 7530 9 considered consider VBN cord-010092-uftc8inx 7530 10 non non JJ cord-010092-uftc8inx 7530 11 - - JJ cord-010092-uftc8inx 7530 12 repeatable repeatable JJ cord-010092-uftc8inx 7530 13 reactive reactive JJ cord-010092-uftc8inx 7530 14 ( ( -LRB- cord-010092-uftc8inx 7530 15 NRR NRR NNP cord-010092-uftc8inx 7530 16 Background Background NNP cord-010092-uftc8inx 7530 17 : : : cord-010092-uftc8inx 7531 1 The the DT cord-010092-uftc8inx 7531 2 Blood Blood NNP cord-010092-uftc8inx 7531 3 Donation Donation NNP cord-010092-uftc8inx 7531 4 Service Service NNP cord-010092-uftc8inx 7531 5 in in IN cord-010092-uftc8inx 7531 6 Suhl Suhl NNP cord-010092-uftc8inx 7531 7 processes process VBZ cord-010092-uftc8inx 7531 8 more more JJR cord-010092-uftc8inx 7531 9 than than IN cord-010092-uftc8inx 7531 10 160.000 160.000 CD cord-010092-uftc8inx 7531 11 samples sample NNS cord-010092-uftc8inx 7531 12 annually annually RB cord-010092-uftc8inx 7531 13 from from IN cord-010092-uftc8inx 7531 14 whole whole JJ cord-010092-uftc8inx 7531 15 blood blood NN cord-010092-uftc8inx 7531 16 and and CC cord-010092-uftc8inx 7531 17 apheresis apheresis NN cord-010092-uftc8inx 7531 18 donations donation NNS cord-010092-uftc8inx 7531 19 , , , cord-010092-uftc8inx 7531 20 testing test VBG cord-010092-uftc8inx 7531 21 on on IN cord-010092-uftc8inx 7531 22 average average JJ cord-010092-uftc8inx 7531 23 around around IN cord-010092-uftc8inx 7531 24 600 600 CD cord-010092-uftc8inx 7531 25 samples sample NNS cord-010092-uftc8inx 7531 26 per per IN cord-010092-uftc8inx 7531 27 day day NN cord-010092-uftc8inx 7531 28 . . . cord-010092-uftc8inx 7532 1 For for IN cord-010092-uftc8inx 7532 2 the the DT cord-010092-uftc8inx 7532 3 last last JJ cord-010092-uftc8inx 7532 4 5 5 CD cord-010092-uftc8inx 7532 5 years year NNS cord-010092-uftc8inx 7532 6 , , , cord-010092-uftc8inx 7532 7 serology serology NN cord-010092-uftc8inx 7532 8 screening screening NN cord-010092-uftc8inx 7532 9 was be VBD cord-010092-uftc8inx 7532 10 performed perform VBN cord-010092-uftc8inx 7532 11 on on IN cord-010092-uftc8inx 7532 12 the the DT cord-010092-uftc8inx 7532 13 ARCHITECT architect NN cord-010092-uftc8inx 7532 14 instruments instrument NNS cord-010092-uftc8inx 7532 15 ( ( -LRB- cord-010092-uftc8inx 7532 16 Abbott Abbott NNP cord-010092-uftc8inx 7532 17 ) ) -RRB- cord-010092-uftc8inx 7532 18 ( ( -LRB- cord-010092-uftc8inx 7532 19 ARC ARC NNP cord-010092-uftc8inx 7532 20 ) ) -RRB- cord-010092-uftc8inx 7532 21 , , , cord-010092-uftc8inx 7532 22 but but CC cord-010092-uftc8inx 7532 23 will will MD cord-010092-uftc8inx 7532 24 be be VB cord-010092-uftc8inx 7532 25 changed change VBN cord-010092-uftc8inx 7532 26 to to IN cord-010092-uftc8inx 7532 27 the the DT cord-010092-uftc8inx 7532 28 ALINITY ALINITY NNP cord-010092-uftc8inx 7532 29 s s POS cord-010092-uftc8inx 7532 30 SYSTEM system NN cord-010092-uftc8inx 7532 31 ( ( -LRB- cord-010092-uftc8inx 7532 32 ALY ALY NNP cord-010092-uftc8inx 7532 33 ) ) -RRB- cord-010092-uftc8inx 7532 34 by by IN cord-010092-uftc8inx 7532 35 middle middle NN cord-010092-uftc8inx 7532 36 of of IN cord-010092-uftc8inx 7532 37 2019 2019 CD cord-010092-uftc8inx 7532 38 . . . cord-010092-uftc8inx 7533 1 Although although IN cord-010092-uftc8inx 7533 2 the the DT cord-010092-uftc8inx 7533 3 design design NN cord-010092-uftc8inx 7533 4 of of IN cord-010092-uftc8inx 7533 5 the the DT cord-010092-uftc8inx 7533 6 ALY ALY NNP cord-010092-uftc8inx 7533 7 assays assay NNS cord-010092-uftc8inx 7533 8 is be VBZ cord-010092-uftc8inx 7533 9 based base VBN cord-010092-uftc8inx 7533 10 on on IN cord-010092-uftc8inx 7533 11 those those DT cord-010092-uftc8inx 7533 12 of of IN cord-010092-uftc8inx 7533 13 the the DT cord-010092-uftc8inx 7533 14 ARC ARC NNP cord-010092-uftc8inx 7533 15 assays assay NNS cord-010092-uftc8inx 7533 16 , , , cord-010092-uftc8inx 7533 17 we -PRON- PRP cord-010092-uftc8inx 7533 18 undertook undertake VBD cord-010092-uftc8inx 7533 19 a a DT cord-010092-uftc8inx 7533 20 thorough thorough JJ cord-010092-uftc8inx 7533 21 evaluation evaluation NN cord-010092-uftc8inx 7533 22 of of IN cord-010092-uftc8inx 7533 23 the the DT cord-010092-uftc8inx 7533 24 four four CD cord-010092-uftc8inx 7533 25 mandatory mandatory JJ cord-010092-uftc8inx 7533 26 screening screening NN cord-010092-uftc8inx 7533 27 assays assay NNS cord-010092-uftc8inx 7533 28 detecting detect VBG cord-010092-uftc8inx 7533 29 HBsAg hbsag ADD cord-010092-uftc8inx 7533 30 , , , cord-010092-uftc8inx 7533 31 HIV HIV NNP cord-010092-uftc8inx 7533 32 Ag Ag NNP cord-010092-uftc8inx 7533 33 / / SYM cord-010092-uftc8inx 7533 34 Ab Ab NNP cord-010092-uftc8inx 7533 35 , , , cord-010092-uftc8inx 7533 36 Anti Anti NNP cord-010092-uftc8inx 7533 37 - - NNP cord-010092-uftc8inx 7533 38 HCV HCV NNP cord-010092-uftc8inx 7533 39 and and CC cord-010092-uftc8inx 7533 40 Anti Anti NNP cord-010092-uftc8inx 7533 41 - - NNP cord-010092-uftc8inx 7533 42 HBc HBc NNP cord-010092-uftc8inx 7533 43 . . . cord-010092-uftc8inx 7534 1 Aims aim VBZ cord-010092-uftc8inx 7534 2 : : : cord-010092-uftc8inx 7535 1 To to TO cord-010092-uftc8inx 7535 2 validate validate VB cord-010092-uftc8inx 7535 3 the the DT cord-010092-uftc8inx 7535 4 4 4 CD cord-010092-uftc8inx 7535 5 mandatory mandatory JJ cord-010092-uftc8inx 7535 6 screening screening NN cord-010092-uftc8inx 7535 7 assays assay NNS cord-010092-uftc8inx 7535 8 on on IN cord-010092-uftc8inx 7535 9 the the DT cord-010092-uftc8inx 7535 10 new new JJ cord-010092-uftc8inx 7535 11 ALY ALY NNP cord-010092-uftc8inx 7535 12 system system NN cord-010092-uftc8inx 7535 13 in in IN cord-010092-uftc8inx 7535 14 our -PRON- PRP$ cord-010092-uftc8inx 7535 15 lab lab NN cord-010092-uftc8inx 7535 16 in in IN cord-010092-uftc8inx 7535 17 terms term NNS cord-010092-uftc8inx 7535 18 of of IN cord-010092-uftc8inx 7535 19 sensitivity sensitivity NN cord-010092-uftc8inx 7535 20 and and CC cord-010092-uftc8inx 7535 21 specificity specificity NN cord-010092-uftc8inx 7535 22 , , , cord-010092-uftc8inx 7535 23 also also RB cord-010092-uftc8inx 7535 24 including include VBG cord-010092-uftc8inx 7535 25 samples sample NNS cord-010092-uftc8inx 7535 26 with with IN cord-010092-uftc8inx 7535 27 known know VBN cord-010092-uftc8inx 7535 28 falsereactive falsereactive NN cord-010092-uftc8inx 7535 29 results result NNS cord-010092-uftc8inx 7535 30 . . . cord-010092-uftc8inx 7536 1 Determine determine VB cord-010092-uftc8inx 7536 2 the the DT cord-010092-uftc8inx 7536 3 rate rate NN cord-010092-uftc8inx 7536 4 of of IN cord-010092-uftc8inx 7536 5 false false JJ cord-010092-uftc8inx 7536 6 reactive reactive JJ cord-010092-uftc8inx 7536 7 results result NNS cord-010092-uftc8inx 7536 8 for for IN cord-010092-uftc8inx 7536 9 HBsAG HBsAG NNP cord-010092-uftc8inx 7536 10 , , , cord-010092-uftc8inx 7536 11 Anti Anti NNP cord-010092-uftc8inx 7536 12 - - NNP cord-010092-uftc8inx 7536 13 HCV HCV NNP cord-010092-uftc8inx 7536 14 and and CC cord-010092-uftc8inx 7536 15 Anti Anti NNP cord-010092-uftc8inx 7536 16 - - JJ cord-010092-uftc8inx 7536 17 HIV HIV NNP cord-010092-uftc8inx 7536 18 that that WDT cord-010092-uftc8inx 7536 19 may may MD cord-010092-uftc8inx 7536 20 lead lead VB cord-010092-uftc8inx 7536 21 to to IN cord-010092-uftc8inx 7536 22 deferrals deferral NNS cord-010092-uftc8inx 7536 23 of of IN cord-010092-uftc8inx 7536 24 donations donation NNS cord-010092-uftc8inx 7536 25 and and CC cord-010092-uftc8inx 7536 26 donors donor NNS cord-010092-uftc8inx 7536 27 . . . cord-010092-uftc8inx 7537 1 Methods method NNS cord-010092-uftc8inx 7537 2 : : : cord-010092-uftc8inx 7537 3 For for IN cord-010092-uftc8inx 7537 4 sensitivity sensitivity NN cord-010092-uftc8inx 7537 5 , , , cord-010092-uftc8inx 7537 6 we -PRON- PRP cord-010092-uftc8inx 7537 7 used use VBD cord-010092-uftc8inx 7537 8 known know VBN cord-010092-uftc8inx 7537 9 positive positive JJ cord-010092-uftc8inx 7537 10 samples sample NNS cord-010092-uftc8inx 7537 11 confirmed confirm VBN cord-010092-uftc8inx 7537 12 by by IN cord-010092-uftc8inx 7537 13 immunoblot immunoblot NNP cord-010092-uftc8inx 7537 14 or or CC cord-010092-uftc8inx 7537 15 NAT NAT NNP cord-010092-uftc8inx 7537 16 . . . cord-010092-uftc8inx 7538 1 Known know VBN cord-010092-uftc8inx 7538 2 unspecific unspecific JJ cord-010092-uftc8inx 7538 3 positive positive JJ cord-010092-uftc8inx 7538 4 samples sample NNS cord-010092-uftc8inx 7538 5 for for IN cord-010092-uftc8inx 7538 6 ARC ARC NNP cord-010092-uftc8inx 7538 7 not not RB cord-010092-uftc8inx 7538 8 confirmed confirm VBN cord-010092-uftc8inx 7538 9 by by IN cord-010092-uftc8inx 7538 10 immunoblot immunoblot NNP cord-010092-uftc8inx 7538 11 or or CC cord-010092-uftc8inx 7538 12 NAT NAT NNP cord-010092-uftc8inx 7538 13 were be VBD cord-010092-uftc8inx 7538 14 testes testis NNS cord-010092-uftc8inx 7538 15 for for IN cord-010092-uftc8inx 7538 16 ALY ALY NNP cord-010092-uftc8inx 7538 17 also also RB cord-010092-uftc8inx 7538 18 . . . cord-010092-uftc8inx 7539 1 Close close RB cord-010092-uftc8inx 7539 2 to to IN cord-010092-uftc8inx 7539 3 2.000 2.000 CD cord-010092-uftc8inx 7539 4 unselected unselected JJ cord-010092-uftc8inx 7539 5 samples sample NNS cord-010092-uftc8inx 7539 6 ( ( -LRB- cord-010092-uftc8inx 7539 7 EDTA edta NN cord-010092-uftc8inx 7539 8 plasma plasma NN cord-010092-uftc8inx 7539 9 ) ) -RRB- cord-010092-uftc8inx 7539 10 from from IN cord-010092-uftc8inx 7539 11 routine routine JJ cord-010092-uftc8inx 7539 12 blood blood NN cord-010092-uftc8inx 7539 13 and and CC cord-010092-uftc8inx 7539 14 apheresis apheresis NN cord-010092-uftc8inx 7539 15 donors donor NNS cord-010092-uftc8inx 7539 16 were be VBD cord-010092-uftc8inx 7539 17 tested test VBN cord-010092-uftc8inx 7539 18 in in IN cord-010092-uftc8inx 7539 19 parallel parallel NN cord-010092-uftc8inx 7539 20 on on IN cord-010092-uftc8inx 7539 21 both both DT cord-010092-uftc8inx 7539 22 systems system NNS cord-010092-uftc8inx 7539 23 , , , cord-010092-uftc8inx 7539 24 ARC ARC NNP cord-010092-uftc8inx 7539 25 and and CC cord-010092-uftc8inx 7539 26 ALY ALY NNP cord-010092-uftc8inx 7539 27 to to TO cord-010092-uftc8inx 7539 28 determine determine VB cord-010092-uftc8inx 7539 29 the the DT cord-010092-uftc8inx 7539 30 rate rate NN cord-010092-uftc8inx 7539 31 of of IN cord-010092-uftc8inx 7539 32 initial initial NN cord-010092-uftc8inx 7539 33 and and CC cord-010092-uftc8inx 7539 34 repeat repeat VB cord-010092-uftc8inx 7539 35 reactive reactive JJ cord-010092-uftc8inx 7539 36 results result NNS cord-010092-uftc8inx 7539 37 . . . cord-010092-uftc8inx 7540 1 Results result NNS cord-010092-uftc8inx 7540 2 : : : cord-010092-uftc8inx 7541 1 All all DT cord-010092-uftc8inx 7541 2 known know VBN cord-010092-uftc8inx 7541 3 confirmed confirm VBD cord-010092-uftc8inx 7541 4 positive positive JJ cord-010092-uftc8inx 7541 5 samples sample NNS cord-010092-uftc8inx 7541 6 were be VBD cord-010092-uftc8inx 7541 7 identical identical JJ cord-010092-uftc8inx 7541 8 detected detect VBN cord-010092-uftc8inx 7541 9 by by IN cord-010092-uftc8inx 7541 10 ALY ALY NNP cord-010092-uftc8inx 7541 11 . . . cord-010092-uftc8inx 7542 1 Samples sample NNS cord-010092-uftc8inx 7542 2 with with IN cord-010092-uftc8inx 7542 3 known know VBN cord-010092-uftc8inx 7542 4 unspecific unspecific JJ cord-010092-uftc8inx 7542 5 reactive reactive JJ cord-010092-uftc8inx 7542 6 results result NNS cord-010092-uftc8inx 7542 7 were be VBD cord-010092-uftc8inx 7542 8 retested reteste VBN cord-010092-uftc8inx 7542 9 by by IN cord-010092-uftc8inx 7542 10 ALY ALY NNP cord-010092-uftc8inx 7542 11 with with IN cord-010092-uftc8inx 7542 12 the the DT cord-010092-uftc8inx 7542 13 following follow VBG cord-010092-uftc8inx 7542 14 results result NNS cord-010092-uftc8inx 7542 15 : : : cord-010092-uftc8inx 7542 16 19/33 19/33 CD cord-010092-uftc8inx 7542 17 Anti Anti NNP cord-010092-uftc8inx 7542 18 - - NNP cord-010092-uftc8inx 7542 19 HCV HCV NNP cord-010092-uftc8inx 7542 20 , , , cord-010092-uftc8inx 7542 21 19/21 19/21 CD cord-010092-uftc8inx 7542 22 HIV HIV NNP cord-010092-uftc8inx 7542 23 Ag Ag NNP cord-010092-uftc8inx 7542 24 / / SYM cord-010092-uftc8inx 7542 25 Ab Ab NNP cord-010092-uftc8inx 7542 26 and and CC cord-010092-uftc8inx 7542 27 04/22 04/22 CD cord-010092-uftc8inx 7542 28 HBsAg hbsag ADD cord-010092-uftc8inx 7542 29 were be VBD cord-010092-uftc8inx 7542 30 found find VBN cord-010092-uftc8inx 7542 31 reactive reactive JJ cord-010092-uftc8inx 7542 32 by by IN cord-010092-uftc8inx 7542 33 ALY ALY NNP cord-010092-uftc8inx 7542 34 to to IN cord-010092-uftc8inx 7542 35 . . . cord-010092-uftc8inx 7543 1 One one CD cord-010092-uftc8inx 7543 2 donation donation NN cord-010092-uftc8inx 7543 3 from from IN cord-010092-uftc8inx 7543 4 an an DT cord-010092-uftc8inx 7543 5 acute acute JJ cord-010092-uftc8inx 7543 6 HIV HIV NNP cord-010092-uftc8inx 7543 7 infection infection NN cord-010092-uftc8inx 7543 8 in in IN cord-010092-uftc8inx 7543 9 the the DT cord-010092-uftc8inx 7543 10 early early JJ cord-010092-uftc8inx 7543 11 seroconversion seroconversion NN cord-010092-uftc8inx 7543 12 period period NN cord-010092-uftc8inx 7543 13 was be VBD cord-010092-uftc8inx 7543 14 detected detect VBN cord-010092-uftc8inx 7543 15 by by IN cord-010092-uftc8inx 7543 16 both both DT cord-010092-uftc8inx 7543 17 methods method NNS cord-010092-uftc8inx 7543 18 in in IN cord-010092-uftc8inx 7543 19 routine routine JJ cord-010092-uftc8inx 7543 20 testing testing NN cord-010092-uftc8inx 7543 21 . . . cord-010092-uftc8inx 7544 1 There there EX cord-010092-uftc8inx 7544 2 are be VBP cord-010092-uftc8inx 7544 3 no no DT cord-010092-uftc8inx 7544 4 reactive reactive JJ cord-010092-uftc8inx 7544 5 results result NNS cord-010092-uftc8inx 7544 6 for for IN cord-010092-uftc8inx 7544 7 ALY ALY NNP cord-010092-uftc8inx 7544 8 not not RB cord-010092-uftc8inx 7544 9 already already RB cord-010092-uftc8inx 7544 10 known know VBN cord-010092-uftc8inx 7544 11 for for IN cord-010092-uftc8inx 7544 12 ARC ARC NNP cord-010092-uftc8inx 7544 13 . . . cord-010092-uftc8inx 7545 1 The the DT cord-010092-uftc8inx 7545 2 specificity specificity NN cord-010092-uftc8inx 7545 3 for for IN cord-010092-uftc8inx 7545 4 the the DT cord-010092-uftc8inx 7545 5 screening screening NN cord-010092-uftc8inx 7545 6 assays assay NNS cord-010092-uftc8inx 7545 7 on on IN cord-010092-uftc8inx 7545 8 ALY ALY NNP cord-010092-uftc8inx 7545 9 versus versus IN cord-010092-uftc8inx 7545 10 ARC ARC NNP cord-010092-uftc8inx 7545 11 assays assay NNS cord-010092-uftc8inx 7545 12 were be VBD cord-010092-uftc8inx 7545 13 as as IN cord-010092-uftc8inx 7545 14 follows follow VBZ cord-010092-uftc8inx 7545 15 : : : cord-010092-uftc8inx 7546 1 1 1 LS cord-010092-uftc8inx 7546 2 ) ) -RRB- cord-010092-uftc8inx 7546 3 HBsAg hbsag ADD cord-010092-uftc8inx 7546 4 ALY ALY NNP cord-010092-uftc8inx 7547 1 100 100 CD cord-010092-uftc8inx 7547 2 . . . cord-010092-uftc8inx 7547 3 00 00 CD cord-010092-uftc8inx 7547 4 % % NN cord-010092-uftc8inx 7547 5 ( ( -LRB- cord-010092-uftc8inx 7547 6 1994 1994 CD cord-010092-uftc8inx 7547 7 00 00 CD cord-010092-uftc8inx 7547 8 % % NN cord-010092-uftc8inx 7547 9 ( ( -LRB- cord-010092-uftc8inx 7547 10 / / SYM cord-010092-uftc8inx 7547 11 1994 1994 CD cord-010092-uftc8inx 7547 12 00 00 CD cord-010092-uftc8inx 7547 13 % % NN cord-010092-uftc8inx 7547 14 ( ( -LRB- cord-010092-uftc8inx 7547 15 ) ) -RRB- cord-010092-uftc8inx 7547 16 vs vs IN cord-010092-uftc8inx 7547 17 ARC ARC NNP cord-010092-uftc8inx 7547 18 99.95 99.95 CD cord-010092-uftc8inx 7547 19 % % NN cord-010092-uftc8inx 7547 20 ( ( -LRB- cord-010092-uftc8inx 7547 21 1993 1993 CD cord-010092-uftc8inx 7547 22 00 00 CD cord-010092-uftc8inx 7547 23 % % NN cord-010092-uftc8inx 7547 24 ( ( -LRB- cord-010092-uftc8inx 7547 25 /1994 /1994 NNP cord-010092-uftc8inx 7547 26 ; ; : cord-010092-uftc8inx 7547 27 2 2 LS cord-010092-uftc8inx 7547 28 ) ) -RRB- cord-010092-uftc8inx 7547 29 HIV HIV NNP cord-010092-uftc8inx 7547 30 ALY ALY NNP cord-010092-uftc8inx 7547 31 and and CC cord-010092-uftc8inx 7547 32 ARC ARC NNP cord-010092-uftc8inx 7547 33 99.95 99.95 CD cord-010092-uftc8inx 7547 34 % % NN cord-010092-uftc8inx 7547 35 ( ( -LRB- cord-010092-uftc8inx 7547 36 1992/1993 1992/1993 CD cord-010092-uftc8inx 7547 37 ) ) -RRB- cord-010092-uftc8inx 7547 38 ; ; : cord-010092-uftc8inx 7547 39 3 3 LS cord-010092-uftc8inx 7547 40 ) ) -RRB- cord-010092-uftc8inx 7547 41 Anti Anti NNP cord-010092-uftc8inx 7547 42 - - NNP cord-010092-uftc8inx 7547 43 HCV HCV NNP cord-010092-uftc8inx 7547 44 ALY ALY NNP cord-010092-uftc8inx 7547 45 99 99 CD cord-010092-uftc8inx 7547 46 . . . cord-010092-uftc8inx 7548 1 90 90 CD cord-010092-uftc8inx 7548 2 % % NN cord-010092-uftc8inx 7548 3 ( ( -LRB- cord-010092-uftc8inx 7548 4 1994 1994 CD cord-010092-uftc8inx 7548 5 90 90 CD cord-010092-uftc8inx 7548 6 % % NN cord-010092-uftc8inx 7548 7 ( ( -LRB- cord-010092-uftc8inx 7548 8 /1996 /1996 CD cord-010092-uftc8inx 7548 9 90 90 CD cord-010092-uftc8inx 7548 10 % % NN cord-010092-uftc8inx 7548 11 ( ( -LRB- cord-010092-uftc8inx 7548 12 ) ) -RRB- cord-010092-uftc8inx 7548 13 vs vs IN cord-010092-uftc8inx 7548 14 ARC ARC NNP cord-010092-uftc8inx 7548 15 99.75 99.75 CD cord-010092-uftc8inx 7548 16 % % NN cord-010092-uftc8inx 7548 17 ( ( -LRB- cord-010092-uftc8inx 7548 18 1991 1991 CD cord-010092-uftc8inx 7548 19 90 90 CD cord-010092-uftc8inx 7548 20 % % NN cord-010092-uftc8inx 7548 21 ( ( -LRB- cord-010092-uftc8inx 7548 22 /1996 /1996 . cord-010092-uftc8inx 7548 23 . . . cord-010092-uftc8inx 7549 1 The the DT cord-010092-uftc8inx 7549 2 number number NN cord-010092-uftc8inx 7549 3 of of IN cord-010092-uftc8inx 7549 4 anti anti JJ cord-010092-uftc8inx 7549 5 - - JJ cord-010092-uftc8inx 7549 6 HBc hbc JJ cord-010092-uftc8inx 7549 7 reactive reactive JJ cord-010092-uftc8inx 7549 8 samples sample NNS cord-010092-uftc8inx 7549 9 did do VBD cord-010092-uftc8inx 7549 10 not not RB cord-010092-uftc8inx 7549 11 differ differ VB cord-010092-uftc8inx 7549 12 between between IN cord-010092-uftc8inx 7549 13 ALY ALY NNP cord-010092-uftc8inx 7549 14 and and CC cord-010092-uftc8inx 7549 15 ARC ARC NNP cord-010092-uftc8inx 7549 16 . . . cord-010092-uftc8inx 7550 1 Summary Summary NNP cord-010092-uftc8inx 7550 2 / / SYM cord-010092-uftc8inx 7550 3 Conclusions conclusion NNS cord-010092-uftc8inx 7550 4 : : : cord-010092-uftc8inx 7550 5 While while IN cord-010092-uftc8inx 7550 6 the the DT cord-010092-uftc8inx 7550 7 switch switch NN cord-010092-uftc8inx 7550 8 to to IN cord-010092-uftc8inx 7550 9 the the DT cord-010092-uftc8inx 7550 10 new new JJ cord-010092-uftc8inx 7550 11 system system NN cord-010092-uftc8inx 7550 12 is be VBZ cord-010092-uftc8inx 7550 13 mainly mainly RB cord-010092-uftc8inx 7550 14 driven drive VBN cord-010092-uftc8inx 7550 15 by by IN cord-010092-uftc8inx 7550 16 operational operational JJ cord-010092-uftc8inx 7550 17 efficiency efficiency NN cord-010092-uftc8inx 7550 18 , , , cord-010092-uftc8inx 7550 19 obviously obviously RB cord-010092-uftc8inx 7550 20 , , , cord-010092-uftc8inx 7550 21 the the DT cord-010092-uftc8inx 7550 22 high high JJ cord-010092-uftc8inx 7550 23 specificity specificity NN cord-010092-uftc8inx 7550 24 of of IN cord-010092-uftc8inx 7550 25 the the DT cord-010092-uftc8inx 7550 26 Alinity Alinity NNP cord-010092-uftc8inx 7550 27 s s POS cord-010092-uftc8inx 7550 28 assay assay NN cord-010092-uftc8inx 7550 29 will will MD cord-010092-uftc8inx 7550 30 reduce reduce VB cord-010092-uftc8inx 7550 31 unnecessary unnecessary JJ cord-010092-uftc8inx 7550 32 deferrals deferral NNS cord-010092-uftc8inx 7550 33 of of IN cord-010092-uftc8inx 7550 34 donations donation NNS cord-010092-uftc8inx 7550 35 and and CC cord-010092-uftc8inx 7550 36 donors donor NNS cord-010092-uftc8inx 7550 37 . . . cord-010092-uftc8inx 7551 1 Abstract Abstract NNP cord-010092-uftc8inx 7551 2 withdrawn withdraw VBN cord-010092-uftc8inx 7551 3 . . . cord-010092-uftc8inx 7552 1 Background background NN cord-010092-uftc8inx 7552 2 : : : cord-010092-uftc8inx 7553 1 Blood blood NN cord-010092-uftc8inx 7553 2 donor donor NN cord-010092-uftc8inx 7553 3 selection selection NN cord-010092-uftc8inx 7553 4 is be VBZ cord-010092-uftc8inx 7553 5 the the DT cord-010092-uftc8inx 7553 6 cornerstone cornerstone NN cord-010092-uftc8inx 7553 7 for for IN cord-010092-uftc8inx 7553 8 blood blood NN cord-010092-uftc8inx 7553 9 transfusion transfusion NN cord-010092-uftc8inx 7553 10 safety safety NN cord-010092-uftc8inx 7553 11 , , , cord-010092-uftc8inx 7553 12 designed design VBN cord-010092-uftc8inx 7553 13 to to TO cord-010092-uftc8inx 7553 14 safeguard safeguard VB cord-010092-uftc8inx 7553 15 the the DT cord-010092-uftc8inx 7553 16 health health NN cord-010092-uftc8inx 7553 17 of of IN cord-010092-uftc8inx 7553 18 both both DT cord-010092-uftc8inx 7553 19 donors donor NNS cord-010092-uftc8inx 7553 20 and and CC cord-010092-uftc8inx 7553 21 recipients recipient NNS cord-010092-uftc8inx 7553 22 . . . cord-010092-uftc8inx 7554 1 Donor donor NN cord-010092-uftc8inx 7554 2 safety safety NN cord-010092-uftc8inx 7554 3 is be VBZ cord-010092-uftc8inx 7554 4 targeted target VBN cord-010092-uftc8inx 7554 5 by by IN cord-010092-uftc8inx 7554 6 reducing reduce VBG cord-010092-uftc8inx 7554 7 the the DT cord-010092-uftc8inx 7554 8 risk risk NN cord-010092-uftc8inx 7554 9 of of IN cord-010092-uftc8inx 7554 10 complications complication NNS cord-010092-uftc8inx 7554 11 associated associate VBN cord-010092-uftc8inx 7554 12 with with IN cord-010092-uftc8inx 7554 13 blood blood NN cord-010092-uftc8inx 7554 14 donation donation NN cord-010092-uftc8inx 7554 15 and and CC cord-010092-uftc8inx 7554 16 transfusion transfusion NN cord-010092-uftc8inx 7554 17 safety safety NN cord-010092-uftc8inx 7554 18 by by IN cord-010092-uftc8inx 7554 19 reducing reduce VBG cord-010092-uftc8inx 7554 20 the the DT cord-010092-uftc8inx 7554 21 risk risk NN cord-010092-uftc8inx 7554 22 of of IN cord-010092-uftc8inx 7554 23 transfusion transfusion NN cord-010092-uftc8inx 7554 24 - - HYPH cord-010092-uftc8inx 7554 25 transmitted transmit VBN cord-010092-uftc8inx 7554 26 infections infection NNS cord-010092-uftc8inx 7554 27 ( ( -LRB- cord-010092-uftc8inx 7554 28 TTI TTI NNP cord-010092-uftc8inx 7554 29 ) ) -RRB- cord-010092-uftc8inx 7554 30 and and CC cord-010092-uftc8inx 7554 31 other other JJ cord-010092-uftc8inx 7554 32 preventable preventable JJ cord-010092-uftc8inx 7554 33 transfusion transfusion NN cord-010092-uftc8inx 7554 34 reactions reaction NNS cord-010092-uftc8inx 7554 35 . . . cord-010092-uftc8inx 7555 1 There there EX cord-010092-uftc8inx 7555 2 is be VBZ cord-010092-uftc8inx 7555 3 always always RB cord-010092-uftc8inx 7555 4 a a DT cord-010092-uftc8inx 7555 5 compromise compromise NN cord-010092-uftc8inx 7555 6 on on IN cord-010092-uftc8inx 7555 7 blood blood NN cord-010092-uftc8inx 7555 8 donor donor NN cord-010092-uftc8inx 7555 9 safety safety NN cord-010092-uftc8inx 7555 10 as as RB cord-010092-uftc8inx 7555 11 well well RB cord-010092-uftc8inx 7555 12 as as IN cord-010092-uftc8inx 7555 13 blood blood NN cord-010092-uftc8inx 7555 14 safety safety NN cord-010092-uftc8inx 7555 15 during during IN cord-010092-uftc8inx 7555 16 outdoor outdoor JJ cord-010092-uftc8inx 7555 17 mega mega JJ cord-010092-uftc8inx 7555 18 blood blood NN cord-010092-uftc8inx 7555 19 donation donation NN cord-010092-uftc8inx 7555 20 drives drive VBZ cord-010092-uftc8inx 7555 21 due due JJ cord-010092-uftc8inx 7555 22 to to IN cord-010092-uftc8inx 7555 23 various various JJ cord-010092-uftc8inx 7555 24 reasons reason NNS cord-010092-uftc8inx 7555 25 , , , cord-010092-uftc8inx 7555 26 mainly mainly RB cord-010092-uftc8inx 7555 27 due due IN cord-010092-uftc8inx 7555 28 to to IN cord-010092-uftc8inx 7555 29 more more JJR cord-010092-uftc8inx 7555 30 number number NN cord-010092-uftc8inx 7555 31 of of IN cord-010092-uftc8inx 7555 32 donations donation NNS cord-010092-uftc8inx 7555 33 within within IN cord-010092-uftc8inx 7555 34 a a DT cord-010092-uftc8inx 7555 35 stipulated stipulate VBN cord-010092-uftc8inx 7555 36 time time NN cord-010092-uftc8inx 7555 37 . . . cord-010092-uftc8inx 7556 1 Aims aim VBZ cord-010092-uftc8inx 7556 2 : : : cord-010092-uftc8inx 7556 3 To to TO cord-010092-uftc8inx 7556 4 compare compare VB cord-010092-uftc8inx 7556 5 the the DT cord-010092-uftc8inx 7556 6 blood blood NN cord-010092-uftc8inx 7556 7 donor donor NN cord-010092-uftc8inx 7556 8 selection selection NN cord-010092-uftc8inx 7556 9 patterns pattern NNS cord-010092-uftc8inx 7556 10 between between IN cord-010092-uftc8inx 7556 11 in in IN cord-010092-uftc8inx 7556 12 house house NN cord-010092-uftc8inx 7556 13 blood blood NN cord-010092-uftc8inx 7556 14 donations donation NNS cord-010092-uftc8inx 7556 15 and and CC cord-010092-uftc8inx 7556 16 donations donation NNS cord-010092-uftc8inx 7556 17 at at IN cord-010092-uftc8inx 7556 18 mega mega JJ cord-010092-uftc8inx 7556 19 blood blood NN cord-010092-uftc8inx 7556 20 donation donation NN cord-010092-uftc8inx 7556 21 drives drive NNS cord-010092-uftc8inx 7556 22 and and CC cord-010092-uftc8inx 7556 23 its -PRON- PRP$ cord-010092-uftc8inx 7556 24 influence influence NN cord-010092-uftc8inx 7556 25 on on IN cord-010092-uftc8inx 7556 26 donor donor NN cord-010092-uftc8inx 7556 27 safety safety NN cord-010092-uftc8inx 7556 28 and and CC cord-010092-uftc8inx 7556 29 blood blood NN cord-010092-uftc8inx 7556 30 safety safety NN cord-010092-uftc8inx 7556 31 in in IN cord-010092-uftc8inx 7556 32 a a DT cord-010092-uftc8inx 7556 33 tertiary tertiary JJ cord-010092-uftc8inx 7556 34 care care NN cord-010092-uftc8inx 7556 35 hospital hospital NN cord-010092-uftc8inx 7556 36 in in IN cord-010092-uftc8inx 7556 37 India India NNP cord-010092-uftc8inx 7556 38 . . . cord-010092-uftc8inx 7557 1 Methods method NNS cord-010092-uftc8inx 7557 2 : : : cord-010092-uftc8inx 7557 3 A a DT cord-010092-uftc8inx 7557 4 retro retro JJ cord-010092-uftc8inx 7557 5 prospective prospective JJ cord-010092-uftc8inx 7557 6 study study NN cord-010092-uftc8inx 7557 7 was be VBD cord-010092-uftc8inx 7557 8 done do VBN cord-010092-uftc8inx 7557 9 to to TO cord-010092-uftc8inx 7557 10 audit audit VB cord-010092-uftc8inx 7557 11 and and CC cord-010092-uftc8inx 7557 12 compare compare VB cord-010092-uftc8inx 7557 13 blood blood NN cord-010092-uftc8inx 7557 14 donor donor NN cord-010092-uftc8inx 7557 15 safety safety NN cord-010092-uftc8inx 7557 16 and and CC cord-010092-uftc8inx 7557 17 blood blood NN cord-010092-uftc8inx 7557 18 safety safety NN cord-010092-uftc8inx 7557 19 over over IN cord-010092-uftc8inx 7557 20 a a DT cord-010092-uftc8inx 7557 21 period period NN cord-010092-uftc8inx 7557 22 of of IN cord-010092-uftc8inx 7557 23 2 2 CD cord-010092-uftc8inx 7557 24 years year NNS cord-010092-uftc8inx 7557 25 from from IN cord-010092-uftc8inx 7557 26 January January NNP cord-010092-uftc8inx 7557 27 2016 2016 CD cord-010092-uftc8inx 7557 28 to to IN cord-010092-uftc8inx 7557 29 December December NNP cord-010092-uftc8inx 7557 30 2017 2017 CD cord-010092-uftc8inx 7557 31 . . . cord-010092-uftc8inx 7558 1 Blood blood NN cord-010092-uftc8inx 7558 2 donor donor NN cord-010092-uftc8inx 7558 3 safety safety NN cord-010092-uftc8inx 7558 4 was be VBD cord-010092-uftc8inx 7558 5 analyzed analyze VBN cord-010092-uftc8inx 7558 6 by by IN cord-010092-uftc8inx 7558 7 two two CD cord-010092-uftc8inx 7558 8 indicators indicator NNS cord-010092-uftc8inx 7558 9 : : : cord-010092-uftc8inx 7558 10 Donor Donor NNP cord-010092-uftc8inx 7558 11 Health Health NNP cord-010092-uftc8inx 7558 12 Questionnaire Questionnaire NNP cord-010092-uftc8inx 7558 13 ( ( -LRB- cord-010092-uftc8inx 7558 14 DHQ DHQ NNP cord-010092-uftc8inx 7558 15 ) ) -RRB- cord-010092-uftc8inx 7558 16 monitoring monitoring NN cord-010092-uftc8inx 7558 17 and and CC cord-010092-uftc8inx 7558 18 blood blood NN cord-010092-uftc8inx 7558 19 donor donor NN cord-010092-uftc8inx 7558 20 reaction reaction NN cord-010092-uftc8inx 7558 21 rates rate NNS cord-010092-uftc8inx 7558 22 and and CC cord-010092-uftc8inx 7558 23 blood blood NN cord-010092-uftc8inx 7558 24 safety safety NN cord-010092-uftc8inx 7558 25 through through IN cord-010092-uftc8inx 7558 26 TTI TTI NNP cord-010092-uftc8inx 7558 27 positivity positivity NN cord-010092-uftc8inx 7558 28 rates rate NNS cord-010092-uftc8inx 7558 29 . . . cord-010092-uftc8inx 7559 1 ( ( -LRB- cord-010092-uftc8inx 7559 2 78 78 CD cord-010092-uftc8inx 7559 3 ) ) -RRB- cord-010092-uftc8inx 7559 4 during during IN cord-010092-uftc8inx 7559 5 mega mega JJ cord-010092-uftc8inx 7559 6 blood blood NN cord-010092-uftc8inx 7559 7 donation donation NN cord-010092-uftc8inx 7559 8 drive drive NN cord-010092-uftc8inx 7559 9 . . . cord-010092-uftc8inx 7560 1 Summary Summary NNP cord-010092-uftc8inx 7560 2 / / SYM cord-010092-uftc8inx 7560 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 7560 4 : : : cord-010092-uftc8inx 7561 1 A a DT cord-010092-uftc8inx 7561 2 good good JJ cord-010092-uftc8inx 7561 3 donor donor NN cord-010092-uftc8inx 7561 4 selection selection NN cord-010092-uftc8inx 7561 5 is be VBZ cord-010092-uftc8inx 7561 6 a a DT cord-010092-uftc8inx 7561 7 lengthy lengthy JJ cord-010092-uftc8inx 7561 8 process process NN cord-010092-uftc8inx 7561 9 which which WDT cord-010092-uftc8inx 7561 10 involves involve VBZ cord-010092-uftc8inx 7561 11 pre pre JJ cord-010092-uftc8inx 7561 12 - - JJ cord-010092-uftc8inx 7561 13 donation donation JJ cord-010092-uftc8inx 7561 14 information information NN cord-010092-uftc8inx 7561 15 and and CC cord-010092-uftc8inx 7561 16 advice advice NN cord-010092-uftc8inx 7561 17 : : : cord-010092-uftc8inx 7561 18 this this DT cord-010092-uftc8inx 7561 19 is be VBZ cord-010092-uftc8inx 7561 20 usually usually RB cord-010092-uftc8inx 7561 21 provided provide VBN cord-010092-uftc8inx 7561 22 in in IN cord-010092-uftc8inx 7561 23 a a DT cord-010092-uftc8inx 7561 24 leaflet leaflet NN cord-010092-uftc8inx 7561 25 , , , cord-010092-uftc8inx 7561 26 especially especially RB cord-010092-uftc8inx 7561 27 about about IN cord-010092-uftc8inx 7561 28 transfusion transfusion NN cord-010092-uftc8inx 7561 29 - - HYPH cord-010092-uftc8inx 7561 30 transmitted transmit VBN cord-010092-uftc8inx 7561 31 infections infection NNS cord-010092-uftc8inx 7561 32 ( ( -LRB- cord-010092-uftc8inx 7561 33 and and CC cord-010092-uftc8inx 7561 34 the the DT cord-010092-uftc8inx 7561 35 associated associated JJ cord-010092-uftc8inx 7561 36 risk risk NN cord-010092-uftc8inx 7561 37 factors factor NNS cord-010092-uftc8inx 7561 38 ) ) -RRB- cord-010092-uftc8inx 7561 39 and and CC cord-010092-uftc8inx 7561 40 the the DT cord-010092-uftc8inx 7561 41 potential potential JJ cord-010092-uftc8inx 7561 42 risks risk NNS cord-010092-uftc8inx 7561 43 of of IN cord-010092-uftc8inx 7561 44 donation donation NN cord-010092-uftc8inx 7561 45 , , , cord-010092-uftc8inx 7561 46 filling filling NN cord-010092-uftc8inx 7561 47 of of IN cord-010092-uftc8inx 7561 48 DHQs dhq NNS cord-010092-uftc8inx 7561 49 by by IN cord-010092-uftc8inx 7561 50 the the DT cord-010092-uftc8inx 7561 51 donor donor NN cord-010092-uftc8inx 7561 52 himself -PRON- PRP cord-010092-uftc8inx 7561 53 , , , cord-010092-uftc8inx 7561 54 donor donor NN cord-010092-uftc8inx 7561 55 interview interview NN cord-010092-uftc8inx 7561 56 : : : cord-010092-uftc8inx 7561 57 conducted conduct VBN cord-010092-uftc8inx 7561 58 by by IN cord-010092-uftc8inx 7561 59 a a DT cord-010092-uftc8inx 7561 60 qualified qualified JJ cord-010092-uftc8inx 7561 61 medical medical JJ cord-010092-uftc8inx 7561 62 specialist specialist NN cord-010092-uftc8inx 7561 63 trained train VBN cord-010092-uftc8inx 7561 64 in in IN cord-010092-uftc8inx 7561 65 donor donor NN cord-010092-uftc8inx 7561 66 selection selection NN cord-010092-uftc8inx 7561 67 process process NN cord-010092-uftc8inx 7561 68 and and CC cord-010092-uftc8inx 7561 69 health health NN cord-010092-uftc8inx 7561 70 assessment assessment NN cord-010092-uftc8inx 7561 71 at at IN cord-010092-uftc8inx 7561 72 the the DT cord-010092-uftc8inx 7561 73 end end NN cord-010092-uftc8inx 7561 74 of of IN cord-010092-uftc8inx 7561 75 the the DT cord-010092-uftc8inx 7561 76 interview interview NN cord-010092-uftc8inx 7561 77 to to TO cord-010092-uftc8inx 7561 78 declare declare VB cord-010092-uftc8inx 7561 79 if if IN cord-010092-uftc8inx 7561 80 the the DT cord-010092-uftc8inx 7561 81 donor donor NN cord-010092-uftc8inx 7561 82 is be VBZ cord-010092-uftc8inx 7561 83 eligible eligible JJ cord-010092-uftc8inx 7561 84 to to TO cord-010092-uftc8inx 7561 85 give give VB cord-010092-uftc8inx 7561 86 blood blood NN cord-010092-uftc8inx 7561 87 or or CC cord-010092-uftc8inx 7561 88 deferred defer VBN cord-010092-uftc8inx 7561 89 temporarily temporarily RB cord-010092-uftc8inx 7561 90 or or CC cord-010092-uftc8inx 7561 91 permanently permanently RB cord-010092-uftc8inx 7561 92 . . . cord-010092-uftc8inx 7562 1 It -PRON- PRP cord-010092-uftc8inx 7562 2 was be VBD cord-010092-uftc8inx 7562 3 observed observe VBN cord-010092-uftc8inx 7562 4 that that IN cord-010092-uftc8inx 7562 5 seroprevalence seroprevalence NN cord-010092-uftc8inx 7562 6 rates rate NNS cord-010092-uftc8inx 7562 7 , , , cord-010092-uftc8inx 7562 8 number number NN cord-010092-uftc8inx 7562 9 of of IN cord-010092-uftc8inx 7562 10 donor donor NN cord-010092-uftc8inx 7562 11 reactions reaction NNS cord-010092-uftc8inx 7562 12 and and CC cord-010092-uftc8inx 7562 13 incompletely incompletely RB cord-010092-uftc8inx 7562 14 filled fill VBN cord-010092-uftc8inx 7562 15 DHQs dhq NNS cord-010092-uftc8inx 7562 16 were be VBD cord-010092-uftc8inx 7562 17 more more JJR cord-010092-uftc8inx 7562 18 among among IN cord-010092-uftc8inx 7562 19 blood blood NN cord-010092-uftc8inx 7562 20 donations donation NNS cord-010092-uftc8inx 7562 21 at at IN cord-010092-uftc8inx 7562 22 mega mega JJ cord-010092-uftc8inx 7562 23 blood blood NN cord-010092-uftc8inx 7562 24 donation donation NN cord-010092-uftc8inx 7562 25 drives drive VBZ cord-010092-uftc8inx 7562 26 when when WRB cord-010092-uftc8inx 7562 27 compared compare VBN cord-010092-uftc8inx 7562 28 to to IN cord-010092-uftc8inx 7562 29 blood blood NN cord-010092-uftc8inx 7562 30 donations donation NNS cord-010092-uftc8inx 7562 31 during during IN cord-010092-uftc8inx 7562 32 in in IN cord-010092-uftc8inx 7562 33 house house NN cord-010092-uftc8inx 7562 34 collections collection NNS cord-010092-uftc8inx 7562 35 . . . cord-010092-uftc8inx 7563 1 This this DT cord-010092-uftc8inx 7563 2 is be VBZ cord-010092-uftc8inx 7563 3 mainly mainly RB cord-010092-uftc8inx 7563 4 due due JJ cord-010092-uftc8inx 7563 5 huge huge JJ cord-010092-uftc8inx 7563 6 number number NN cord-010092-uftc8inx 7563 7 of of IN cord-010092-uftc8inx 7563 8 blood blood NN cord-010092-uftc8inx 7563 9 donations donation NNS cord-010092-uftc8inx 7563 10 with with IN cord-010092-uftc8inx 7563 11 in in IN cord-010092-uftc8inx 7563 12 a a DT cord-010092-uftc8inx 7563 13 stipulated stipulate VBN cord-010092-uftc8inx 7563 14 time time NN cord-010092-uftc8inx 7563 15 where where WRB cord-010092-uftc8inx 7563 16 there there EX cord-010092-uftc8inx 7563 17 is be VBZ cord-010092-uftc8inx 7563 18 limited limited JJ cord-010092-uftc8inx 7563 19 time time NN cord-010092-uftc8inx 7563 20 spent spend VBN cord-010092-uftc8inx 7563 21 on on IN cord-010092-uftc8inx 7563 22 proper proper JJ cord-010092-uftc8inx 7563 23 donor donor NN cord-010092-uftc8inx 7563 24 selection selection NN cord-010092-uftc8inx 7563 25 . . . cord-010092-uftc8inx 7564 1 Stringent stringent JJ cord-010092-uftc8inx 7564 2 implementation implementation NN cord-010092-uftc8inx 7564 3 of of IN cord-010092-uftc8inx 7564 4 WHO who WP cord-010092-uftc8inx 7564 5 strategy strategy NN cord-010092-uftc8inx 7564 6 : : : cord-010092-uftc8inx 7564 7 " " `` cord-010092-uftc8inx 7564 8 safe safe JJ cord-010092-uftc8inx 7564 9 donor donor NN cord-010092-uftc8inx 7564 10 safe safe JJ cord-010092-uftc8inx 7564 11 blood blood NN cord-010092-uftc8inx 7564 12 " " '' cord-010092-uftc8inx 7564 13 is be VBZ cord-010092-uftc8inx 7564 14 the the DT cord-010092-uftc8inx 7564 15 only only JJ cord-010092-uftc8inx 7564 16 way way NN cord-010092-uftc8inx 7564 17 for for IN cord-010092-uftc8inx 7564 18 blood blood NN cord-010092-uftc8inx 7564 19 donor donor NN cord-010092-uftc8inx 7564 20 and and CC cord-010092-uftc8inx 7564 21 transfusion transfusion NN cord-010092-uftc8inx 7564 22 safety safety NN cord-010092-uftc8inx 7564 23 . . . cord-010092-uftc8inx 7565 1 Background background NN cord-010092-uftc8inx 7565 2 : : : cord-010092-uftc8inx 7566 1 Safety safety NN cord-010092-uftc8inx 7566 2 of of IN cord-010092-uftc8inx 7566 3 blood blood NN cord-010092-uftc8inx 7566 4 transfusion transfusion NN cord-010092-uftc8inx 7566 5 is be VBZ cord-010092-uftc8inx 7566 6 a a DT cord-010092-uftc8inx 7566 7 great great JJ cord-010092-uftc8inx 7566 8 concern concern NN cord-010092-uftc8inx 7566 9 especially especially RB cord-010092-uftc8inx 7566 10 in in IN cord-010092-uftc8inx 7566 11 crisis crisis NN cord-010092-uftc8inx 7566 12 countries country NNS cord-010092-uftc8inx 7566 13 and and CC cord-010092-uftc8inx 7566 14 during during IN cord-010092-uftc8inx 7566 15 humanitarian humanitarian JJ cord-010092-uftc8inx 7566 16 emergencies emergency NNS cord-010092-uftc8inx 7566 17 . . . cord-010092-uftc8inx 7567 1 Transfusion transfusion NN cord-010092-uftc8inx 7567 2 transmitted transmit VBD cord-010092-uftc8inx 7567 3 infections infection NNS cord-010092-uftc8inx 7567 4 ( ( -LRB- cord-010092-uftc8inx 7567 5 TTIs tti NNS cord-010092-uftc8inx 7567 6 ) ) -RRB- cord-010092-uftc8inx 7567 7 are be VBP cord-010092-uftc8inx 7567 8 one one CD cord-010092-uftc8inx 7567 9 of of IN cord-010092-uftc8inx 7567 10 the the DT cord-010092-uftc8inx 7567 11 major major JJ cord-010092-uftc8inx 7567 12 health health NN cord-010092-uftc8inx 7567 13 problem problem NN cord-010092-uftc8inx 7567 14 in in IN cord-010092-uftc8inx 7567 15 Yemen Yemen NNP cord-010092-uftc8inx 7567 16 that that WDT cord-010092-uftc8inx 7567 17 are be VBP cord-010092-uftc8inx 7567 18 associated associate VBN cord-010092-uftc8inx 7567 19 with with IN cord-010092-uftc8inx 7567 20 blood blood NN cord-010092-uftc8inx 7567 21 transfusion transfusion NN cord-010092-uftc8inx 7567 22 complications complication NNS cord-010092-uftc8inx 7567 23 . . . cord-010092-uftc8inx 7568 1 Aims aim VBZ cord-010092-uftc8inx 7568 2 : : : cord-010092-uftc8inx 7569 1 The the DT cord-010092-uftc8inx 7569 2 aim aim NN cord-010092-uftc8inx 7569 3 of of IN cord-010092-uftc8inx 7569 4 this this DT cord-010092-uftc8inx 7569 5 study study NN cord-010092-uftc8inx 7569 6 is be VBZ cord-010092-uftc8inx 7569 7 to to TO cord-010092-uftc8inx 7569 8 determine determine VB cord-010092-uftc8inx 7569 9 the the DT cord-010092-uftc8inx 7569 10 prevalence prevalence NN cord-010092-uftc8inx 7569 11 of of IN cord-010092-uftc8inx 7569 12 TTIs tti NNS cord-010092-uftc8inx 7569 13 among among IN cord-010092-uftc8inx 7569 14 blood blood NN cord-010092-uftc8inx 7569 15 donors donor NNS cord-010092-uftc8inx 7569 16 at at IN cord-010092-uftc8inx 7569 17 National National NNP cord-010092-uftc8inx 7569 18 Blood Blood NNP cord-010092-uftc8inx 7569 19 Transfusion Transfusion NNP cord-010092-uftc8inx 7569 20 and and CC cord-010092-uftc8inx 7569 21 Researcher Researcher NNP cord-010092-uftc8inx 7569 22 Center Center NNP cord-010092-uftc8inx 7570 1 ( ( -LRB- cord-010092-uftc8inx 7570 2 NBTRC NBTRC NNP cord-010092-uftc8inx 7570 3 This this DT cord-010092-uftc8inx 7570 4 contributed contribute VBD cord-010092-uftc8inx 7570 5 to to IN cord-010092-uftc8inx 7570 6 an an DT cord-010092-uftc8inx 7570 7 additional additional JJ cord-010092-uftc8inx 7570 8 reactivity reactivity NN cord-010092-uftc8inx 7570 9 of of IN cord-010092-uftc8inx 7570 10 0.09 0.09 CD cord-010092-uftc8inx 7570 11 % % NN cord-010092-uftc8inx 7570 12 , , , cord-010092-uftc8inx 7570 13 thereby thereby RB cord-010092-uftc8inx 7570 14 total total JJ cord-010092-uftc8inx 7570 15 reactivity reactivity NN cord-010092-uftc8inx 7570 16 being be VBG cord-010092-uftc8inx 7570 17 2.39 2.39 CD cord-010092-uftc8inx 7570 18 % % NN cord-010092-uftc8inx 7570 19 . . . cord-010092-uftc8inx 7571 1 55 55 CD cord-010092-uftc8inx 7571 2 % % NN cord-010092-uftc8inx 7571 3 ( ( -LRB- cord-010092-uftc8inx 7571 4 22/40 22/40 CD cord-010092-uftc8inx 7571 5 ) ) -RRB- cord-010092-uftc8inx 7571 6 of of IN cord-010092-uftc8inx 7571 7 these these DT cord-010092-uftc8inx 7571 8 were be VBD cord-010092-uftc8inx 7571 9 HCV HCV NNP cord-010092-uftc8inx 7571 10 reactive reactive NNP cord-010092-uftc8inx 7571 11 & & CC cord-010092-uftc8inx 7571 12 45 45 CD cord-010092-uftc8inx 7571 13 % % NN cord-010092-uftc8inx 7571 14 ( ( -LRB- cord-010092-uftc8inx 7571 15 18/40 18/40 CD cord-010092-uftc8inx 7571 16 ) ) -RRB- cord-010092-uftc8inx 7571 17 for for IN cord-010092-uftc8inx 7571 18 HBV HBV NNP cord-010092-uftc8inx 7571 19 . . . cord-010092-uftc8inx 7572 1 The the DT cord-010092-uftc8inx 7572 2 NAT NAT NNP cord-010092-uftc8inx 7572 3 yield yield NN cord-010092-uftc8inx 7572 4 was be VBD cord-010092-uftc8inx 7572 5 1 1 CD cord-010092-uftc8inx 7572 6 in in IN cord-010092-uftc8inx 7572 7 1086 1086 CD cord-010092-uftc8inx 7572 8 and and CC cord-010092-uftc8inx 7572 9 the the DT cord-010092-uftc8inx 7572 10 viral viral JJ cord-010092-uftc8inx 7572 11 loads load NNS cord-010092-uftc8inx 7572 12 of of IN cord-010092-uftc8inx 7572 13 NAT NAT NNP cord-010092-uftc8inx 7572 14 reactives reactive NNS cord-010092-uftc8inx 7572 15 ranged range VBD cord-010092-uftc8inx 7572 16 from from IN cord-010092-uftc8inx 7572 17 1 1 CD cord-010092-uftc8inx 7572 18 - - SYM cord-010092-uftc8inx 7572 19 9 9 CD cord-010092-uftc8inx 7572 20 x10 x10 CD cord-010092-uftc8inx 7572 21 4 4 CD cord-010092-uftc8inx 7572 22 IU IU NNP cord-010092-uftc8inx 7572 23 / / , cord-010092-uftc8inx 7572 24 ml ml NN cord-010092-uftc8inx 7572 25 for for IN cord-010092-uftc8inx 7572 26 HCV HCV NNP cord-010092-uftc8inx 7572 27 & & CC cord-010092-uftc8inx 7572 28 all all PDT cord-010092-uftc8inx 7572 29 the the DT cord-010092-uftc8inx 7572 30 HBV HBV NNP cord-010092-uftc8inx 7572 31 yields yield NNS cord-010092-uftc8inx 7572 32 had have VBD cord-010092-uftc8inx 7572 33 an an DT cord-010092-uftc8inx 7572 34 extremely extremely RB cord-010092-uftc8inx 7572 35 viral viral JJ cord-010092-uftc8inx 7572 36 load load NN cord-010092-uftc8inx 7572 37 of of IN cord-010092-uftc8inx 7572 38 < < XX cord-010092-uftc8inx 7572 39 06 06 CD cord-010092-uftc8inx 7572 40 IU IU NNP cord-010092-uftc8inx 7572 41 / / , cord-010092-uftc8inx 7572 42 ml ml NN cord-010092-uftc8inx 7572 43 . . . cord-010092-uftc8inx 7573 1 12/40 12/40 CD cord-010092-uftc8inx 7573 2 NAT NAT NNP cord-010092-uftc8inx 7573 3 reactive reactive JJ cord-010092-uftc8inx 7573 4 showed show VBD cord-010092-uftc8inx 7573 5 sero sero NN cord-010092-uftc8inx 7573 6 - - HYPH cord-010092-uftc8inx 7573 7 conversion conversion NN cord-010092-uftc8inx 7573 8 after after IN cord-010092-uftc8inx 7573 9 4 4 CD cord-010092-uftc8inx 7573 10 - - SYM cord-010092-uftc8inx 7573 11 8 8 CD cord-010092-uftc8inx 7573 12 months month NNS cord-010092-uftc8inx 7573 13 with with IN cord-010092-uftc8inx 7573 14 follow follow NN cord-010092-uftc8inx 7573 15 - - HYPH cord-010092-uftc8inx 7573 16 up up NN cord-010092-uftc8inx 7573 17 ECLIA eclia NN cord-010092-uftc8inx 7573 18 screening screening NN cord-010092-uftc8inx 7573 19 , , , cord-010092-uftc8inx 7573 20 and and CC cord-010092-uftc8inx 7573 21 7 7 CD cord-010092-uftc8inx 7573 22 of of IN cord-010092-uftc8inx 7573 23 these these DT cord-010092-uftc8inx 7573 24 were be VBD cord-010092-uftc8inx 7573 25 HCV HCV NNP cord-010092-uftc8inx 7573 26 reactive reactive JJ cord-010092-uftc8inx 7573 27 and and CC cord-010092-uftc8inx 7573 28 4 4 CD cord-010092-uftc8inx 7573 29 HBV HBV NNP cord-010092-uftc8inx 7573 30 reactives reactive NNS cord-010092-uftc8inx 7573 31 . . . cord-010092-uftc8inx 7574 1 Summary Summary NNP cord-010092-uftc8inx 7574 2 / / SYM cord-010092-uftc8inx 7574 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 7574 4 : : : cord-010092-uftc8inx 7575 1 Incidence incidence NN cord-010092-uftc8inx 7575 2 rate rate NN cord-010092-uftc8inx 7575 3 indicate indicate VBP cord-010092-uftc8inx 7575 4 that that IN cord-010092-uftc8inx 7575 5 the the DT cord-010092-uftc8inx 7575 6 current current JJ cord-010092-uftc8inx 7575 7 risk risk NN cord-010092-uftc8inx 7575 8 of of IN cord-010092-uftc8inx 7575 9 transfusion transfusion NN cord-010092-uftc8inx 7575 10 transmitted transmit VBN cord-010092-uftc8inx 7575 11 viral viral JJ cord-010092-uftc8inx 7575 12 infections infection NNS cord-010092-uftc8inx 7575 13 attributable attributable JJ cord-010092-uftc8inx 7575 14 to to IN cord-010092-uftc8inx 7575 15 blood blood NN cord-010092-uftc8inx 7575 16 donation donation NN cord-010092-uftc8inx 7575 17 is be VBZ cord-010092-uftc8inx 7575 18 relatively relatively RB cord-010092-uftc8inx 7575 19 high high JJ cord-010092-uftc8inx 7575 20 in in IN cord-010092-uftc8inx 7575 21 our -PRON- PRP$ cord-010092-uftc8inx 7575 22 country country NN cord-010092-uftc8inx 7575 23 . . . cord-010092-uftc8inx 7576 1 Parallel parallel JJ cord-010092-uftc8inx 7576 2 use use NN cord-010092-uftc8inx 7576 3 of of IN cord-010092-uftc8inx 7576 4 both both DT cord-010092-uftc8inx 7576 5 serology serology NN cord-010092-uftc8inx 7576 6 and and CC cord-010092-uftc8inx 7576 7 NAT NAT NNP cord-010092-uftc8inx 7576 8 screening screening NN cord-010092-uftc8inx 7576 9 of of IN cord-010092-uftc8inx 7576 10 donated donate VBN cord-010092-uftc8inx 7576 11 blood blood NN cord-010092-uftc8inx 7576 12 in in IN cord-010092-uftc8inx 7576 13 countries country NNS cord-010092-uftc8inx 7576 14 that that WDT cord-010092-uftc8inx 7576 15 have have VBP cord-010092-uftc8inx 7576 16 high high JJ cord-010092-uftc8inx 7576 17 seroprevalence seroprevalence NN cord-010092-uftc8inx 7576 18 can can MD cord-010092-uftc8inx 7576 19 improve improve VB cord-010092-uftc8inx 7576 20 the the DT cord-010092-uftc8inx 7576 21 blood blood NN cord-010092-uftc8inx 7576 22 safety safety NN cord-010092-uftc8inx 7576 23 . . . cord-010092-uftc8inx 7577 1 At at IN cord-010092-uftc8inx 7577 2 our -PRON- PRP$ cord-010092-uftc8inx 7577 3 centre centre NN cord-010092-uftc8inx 7577 4 , , , cord-010092-uftc8inx 7577 5 by by IN cord-010092-uftc8inx 7577 6 using use VBG cord-010092-uftc8inx 7577 7 best good JJS cord-010092-uftc8inx 7577 8 in in IN cord-010092-uftc8inx 7577 9 class class NN cord-010092-uftc8inx 7577 10 serology serology NN cord-010092-uftc8inx 7577 11 and and CC cord-010092-uftc8inx 7577 12 NAT NAT NNP cord-010092-uftc8inx 7577 13 technologies technology NNS cord-010092-uftc8inx 7577 14 , , , cord-010092-uftc8inx 7577 15 we -PRON- PRP cord-010092-uftc8inx 7577 16 were be VBD cord-010092-uftc8inx 7577 17 would would MD cord-010092-uftc8inx 7577 18 add add VB cord-010092-uftc8inx 7577 19 an an DT cord-010092-uftc8inx 7577 20 extra extra JJ cord-010092-uftc8inx 7577 21 layer layer NN cord-010092-uftc8inx 7577 22 of of IN cord-010092-uftc8inx 7577 23 safety safety NN cord-010092-uftc8inx 7577 24 to to IN cord-010092-uftc8inx 7577 25 blood blood NN cord-010092-uftc8inx 7577 26 supply supply NN cord-010092-uftc8inx 7577 27 by by IN cord-010092-uftc8inx 7577 28 interdicting interdict VBG cord-010092-uftc8inx 7577 29 samples sample NNS cord-010092-uftc8inx 7577 30 from from IN cord-010092-uftc8inx 7577 31 donor donor NN cord-010092-uftc8inx 7577 32 with with IN cord-010092-uftc8inx 7577 33 recent recent JJ cord-010092-uftc8inx 7577 34 infections infection NNS cord-010092-uftc8inx 7577 35 . . . cord-010092-uftc8inx 7578 1 Abstract Abstract NNP cord-010092-uftc8inx 7578 2 withdrawn withdraw VBN cord-010092-uftc8inx 7578 3 . . . cord-010092-uftc8inx 7579 1 Abstract Abstract NNP cord-010092-uftc8inx 7579 2 withdrawn withdraw VBN cord-010092-uftc8inx 7579 3 . . . cord-010092-uftc8inx 7580 1 ( ( -LRB- cord-010092-uftc8inx 7580 2 1/190,298 1/190,298 CD cord-010092-uftc8inx 7580 3 ) ) -RRB- cord-010092-uftc8inx 7580 4 . . . cord-010092-uftc8inx 7581 1 The the DT cord-010092-uftc8inx 7581 2 both both DT cord-010092-uftc8inx 7581 3 HIV HIV NNP cord-010092-uftc8inx 7581 4 - - HYPH cord-010092-uftc8inx 7581 5 RNA RNA NNP cord-010092-uftc8inx 7581 6 and and CC cord-010092-uftc8inx 7581 7 HCV HCV NNP cord-010092-uftc8inx 7581 8 - - HYPH cord-010092-uftc8inx 7581 9 RNA RNA NNP cord-010092-uftc8inx 7581 10 detected detect VBD cord-010092-uftc8inx 7581 11 donors donor NNS cord-010092-uftc8inx 7581 12 by by IN cord-010092-uftc8inx 7581 13 NAT NAT NNP cord-010092-uftc8inx 7581 14 were be VBD cord-010092-uftc8inx 7581 15 identified identify VBN cord-010092-uftc8inx 7581 16 in in IN cord-010092-uftc8inx 7581 17 the the DT cord-010092-uftc8inx 7581 18 window window NN cord-010092-uftc8inx 7581 19 period period NN cord-010092-uftc8inx 7581 20 . . . cord-010092-uftc8inx 7582 1 Summary Summary NNP cord-010092-uftc8inx 7582 2 / / SYM cord-010092-uftc8inx 7582 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 7582 4 : : : cord-010092-uftc8inx 7583 1 In in IN cord-010092-uftc8inx 7583 2 this this DT cord-010092-uftc8inx 7583 3 study study NN cord-010092-uftc8inx 7583 4 , , , cord-010092-uftc8inx 7583 5 we -PRON- PRP cord-010092-uftc8inx 7583 6 found find VBD cord-010092-uftc8inx 7583 7 that that IN cord-010092-uftc8inx 7583 8 NAT NAT NNP cord-010092-uftc8inx 7583 9 could could MD cord-010092-uftc8inx 7583 10 detect detect VB cord-010092-uftc8inx 7583 11 283 283 CD cord-010092-uftc8inx 7583 12 infected infect VBN cord-010092-uftc8inx 7583 13 cases case NNS cord-010092-uftc8inx 7583 14 with with IN cord-010092-uftc8inx 7583 15 HBV HBV NNP cord-010092-uftc8inx 7583 16 - - HYPH cord-010092-uftc8inx 7583 17 DNA DNA NNP cord-010092-uftc8inx 7583 18 , , , cord-010092-uftc8inx 7583 19 HIV HIV NNP cord-010092-uftc8inx 7583 20 - - HYPH cord-010092-uftc8inx 7583 21 RNA RNA NNP cord-010092-uftc8inx 7583 22 and and CC cord-010092-uftc8inx 7583 23 HCV HCV NNP cord-010092-uftc8inx 7583 24 - - HYPH cord-010092-uftc8inx 7583 25 RNA RNA NNP cord-010092-uftc8inx 7583 26 which which WDT cord-010092-uftc8inx 7583 27 were be VBD cord-010092-uftc8inx 7583 28 forgotten forget VBN cord-010092-uftc8inx 7583 29 by by IN cord-010092-uftc8inx 7583 30 serological serological JJ cord-010092-uftc8inx 7583 31 methods method NNS cord-010092-uftc8inx 7584 1 Therefore therefore RB cord-010092-uftc8inx 7584 2 , , , cord-010092-uftc8inx 7584 3 NAT NAT NNP cord-010092-uftc8inx 7584 4 is be VBZ cord-010092-uftc8inx 7584 5 a a DT cord-010092-uftc8inx 7584 6 sensitive sensitive JJ cord-010092-uftc8inx 7584 7 screening screening NN cord-010092-uftc8inx 7584 8 method method NN cord-010092-uftc8inx 7584 9 to to TO cord-010092-uftc8inx 7584 10 detect detect VB cord-010092-uftc8inx 7584 11 low low JJ cord-010092-uftc8inx 7584 12 viral viral JJ cord-010092-uftc8inx 7584 13 load load NN cord-010092-uftc8inx 7584 14 and and CC cord-010092-uftc8inx 7584 15 shorten shorten VB cord-010092-uftc8inx 7584 16 the the DT cord-010092-uftc8inx 7584 17 window window NN cord-010092-uftc8inx 7584 18 period period NN cord-010092-uftc8inx 7584 19 of of IN cord-010092-uftc8inx 7584 20 the the DT cord-010092-uftc8inx 7584 21 virus virus NN cord-010092-uftc8inx 7584 22 infection infection NN cord-010092-uftc8inx 7584 23 to to TO cord-010092-uftc8inx 7584 24 ensure ensure VB cord-010092-uftc8inx 7584 25 the the DT cord-010092-uftc8inx 7584 26 safety safety NN cord-010092-uftc8inx 7584 27 of of IN cord-010092-uftc8inx 7584 28 blood blood NN cord-010092-uftc8inx 7584 29 transfusions transfusion NNS cord-010092-uftc8inx 7584 30 . . . cord-010092-uftc8inx 7585 1 Service Service NNP cord-010092-uftc8inx 7585 2 Du Du NNP cord-010092-uftc8inx 7585 3 Sang Sang NNP cord-010092-uftc8inx 7585 4 , , , cord-010092-uftc8inx 7585 5 Croix Croix NNP cord-010092-uftc8inx 7585 6 Rouge Rouge NNP cord-010092-uftc8inx 7585 7 De De NNP cord-010092-uftc8inx 7585 8 Belgique Belgique NNP cord-010092-uftc8inx 7585 9 , , , cord-010092-uftc8inx 7585 10 Namur Namur NNP cord-010092-uftc8inx 7585 11 , , , cord-010092-uftc8inx 7585 12 Belgium Belgium NNP cord-010092-uftc8inx 7585 13 Background Background NNP cord-010092-uftc8inx 7585 14 : : : cord-010092-uftc8inx 7585 15 Due due IN cord-010092-uftc8inx 7585 16 to to IN cord-010092-uftc8inx 7585 17 enhancement enhancement NN cord-010092-uftc8inx 7585 18 of of IN cord-010092-uftc8inx 7585 19 kits kit NNS cord-010092-uftc8inx 7585 20 specificity specificity NN cord-010092-uftc8inx 7585 21 and and CC cord-010092-uftc8inx 7585 22 machines machine NNS cord-010092-uftc8inx 7585 23 throughput throughput NN cord-010092-uftc8inx 7585 24 , , , cord-010092-uftc8inx 7585 25 Roche Roche NNP cord-010092-uftc8inx 7585 26 Elecsys Elecsys NNP cord-010092-uftc8inx 7585 27 â â , cord-010092-uftc8inx 7585 28 technology technology NN cord-010092-uftc8inx 7585 29 is be VBZ cord-010092-uftc8inx 7585 30 a a DT cord-010092-uftc8inx 7585 31 potential potential JJ cord-010092-uftc8inx 7585 32 partner partner NN cord-010092-uftc8inx 7585 33 for for IN cord-010092-uftc8inx 7585 34 blood blood NN cord-010092-uftc8inx 7585 35 donations donation NNS cord-010092-uftc8inx 7585 36 screening screening NN cord-010092-uftc8inx 7585 37 laboratories laboratory NNS cord-010092-uftc8inx 7585 38 . . . cord-010092-uftc8inx 7586 1 Aims aim VBZ cord-010092-uftc8inx 7586 2 : : : cord-010092-uftc8inx 7587 1 The the DT cord-010092-uftc8inx 7587 2 aim aim NN cord-010092-uftc8inx 7587 3 of of IN cord-010092-uftc8inx 7587 4 the the DT cord-010092-uftc8inx 7587 5 study study NN cord-010092-uftc8inx 7587 6 was be VBD cord-010092-uftc8inx 7587 7 to to TO cord-010092-uftc8inx 7587 8 assess assess VB cord-010092-uftc8inx 7587 9 the the DT cord-010092-uftc8inx 7587 10 performance performance NN cord-010092-uftc8inx 7587 11 of of IN cord-010092-uftc8inx 7587 12 the the DT cord-010092-uftc8inx 7587 13 Elecsys Elecsys NNP cord-010092-uftc8inx 7587 14 serology serology NN cord-010092-uftc8inx 7587 15 assays assay NNS cord-010092-uftc8inx 7587 16 on on IN cord-010092-uftc8inx 7587 17 a a DT cord-010092-uftc8inx 7587 18 cobas cobas NN cord-010092-uftc8inx 7587 19 e801 e801 NN cord-010092-uftc8inx 7587 20 equipment equipment NN cord-010092-uftc8inx 7587 21 for for IN cord-010092-uftc8inx 7587 22 clinical clinical JJ cord-010092-uftc8inx 7587 23 specificity specificity NN cord-010092-uftc8inx 7587 24 , , , cord-010092-uftc8inx 7587 25 analytical analytical JJ cord-010092-uftc8inx 7587 26 sensitivity sensitivity NN cord-010092-uftc8inx 7587 27 and and CC cord-010092-uftc8inx 7587 28 reproducibility reproducibility NN cord-010092-uftc8inx 7587 29 . . . cord-010092-uftc8inx 7588 1 Background background NN cord-010092-uftc8inx 7588 2 : : : cord-010092-uftc8inx 7589 1 Deceased deceased JJ cord-010092-uftc8inx 7589 2 donors donor NNS cord-010092-uftc8inx 7589 3 are be VBP cord-010092-uftc8inx 7589 4 the the DT cord-010092-uftc8inx 7589 5 primary primary JJ cord-010092-uftc8inx 7589 6 source source NN cord-010092-uftc8inx 7589 7 of of IN cord-010092-uftc8inx 7589 8 organs organ NNS cord-010092-uftc8inx 7589 9 and and CC cord-010092-uftc8inx 7589 10 tissues tissue NNS cord-010092-uftc8inx 7589 11 for for IN cord-010092-uftc8inx 7589 12 transplantation transplantation NN cord-010092-uftc8inx 7589 13 but but CC cord-010092-uftc8inx 7589 14 the the DT cord-010092-uftc8inx 7589 15 risk risk NN cord-010092-uftc8inx 7589 16 of of IN cord-010092-uftc8inx 7589 17 infectious infectious JJ cord-010092-uftc8inx 7589 18 complications complication NNS cord-010092-uftc8inx 7589 19 in in IN cord-010092-uftc8inx 7589 20 the the DT cord-010092-uftc8inx 7589 21 recipient recipient NN cord-010092-uftc8inx 7589 22 is be VBZ cord-010092-uftc8inx 7589 23 high high JJ cord-010092-uftc8inx 7589 24 and and CC cord-010092-uftc8inx 7589 25 is be VBZ cord-010092-uftc8inx 7589 26 the the DT cord-010092-uftc8inx 7589 27 main main JJ cord-010092-uftc8inx 7589 28 cause cause NN cord-010092-uftc8inx 7589 29 of of IN cord-010092-uftc8inx 7589 30 morbidity morbidity NN cord-010092-uftc8inx 7589 31 and and CC cord-010092-uftc8inx 7589 32 mortality mortality NN cord-010092-uftc8inx 7589 33 after after IN cord-010092-uftc8inx 7589 34 transplantation transplantation NN cord-010092-uftc8inx 7589 35 . . . cord-010092-uftc8inx 7590 1 To to TO cord-010092-uftc8inx 7590 2 minimize minimize VB cord-010092-uftc8inx 7590 3 the the DT cord-010092-uftc8inx 7590 4 risk risk NN cord-010092-uftc8inx 7590 5 of of IN cord-010092-uftc8inx 7590 6 infections infection NNS cord-010092-uftc8inx 7590 7 by by IN cord-010092-uftc8inx 7590 8 organ organ NN cord-010092-uftc8inx 7590 9 or or CC cord-010092-uftc8inx 7590 10 tissue tissue NN cord-010092-uftc8inx 7590 11 transplantation transplantation NN cord-010092-uftc8inx 7590 12 , , , cord-010092-uftc8inx 7590 13 donors donor NNS cord-010092-uftc8inx 7590 14 should should MD cord-010092-uftc8inx 7590 15 be be VB cord-010092-uftc8inx 7590 16 tested test VBN cord-010092-uftc8inx 7590 17 for for IN cord-010092-uftc8inx 7590 18 Anti Anti NNP cord-010092-uftc8inx 7590 19 - - NN cord-010092-uftc8inx 7590 20 HIV-1/2 hiv-1/2 JJ cord-010092-uftc8inx 7590 21 , , , cord-010092-uftc8inx 7590 22 HBsAg hbsag ADD cord-010092-uftc8inx 7590 23 , , , cord-010092-uftc8inx 7590 24 Anti Anti NNP cord-010092-uftc8inx 7590 25 - - JJ cord-010092-uftc8inx 7590 26 HBc HBc NNP cord-010092-uftc8inx 7590 27 , , , cord-010092-uftc8inx 7590 28 Anti Anti NNP cord-010092-uftc8inx 7590 29 - - NNP cord-010092-uftc8inx 7590 30 HCV HCV NNP cord-010092-uftc8inx 7590 31 , , , cord-010092-uftc8inx 7590 32 and and CC cord-010092-uftc8inx 7590 33 Syphilis Syphilis NNP cord-010092-uftc8inx 7590 34 . . . cord-010092-uftc8inx 7591 1 Further further JJ cord-010092-uftc8inx 7591 2 laboratory laboratory NN cord-010092-uftc8inx 7591 3 tests test NNS cord-010092-uftc8inx 7591 4 may may MD cord-010092-uftc8inx 7591 5 be be VB cord-010092-uftc8inx 7591 6 required require VBN cord-010092-uftc8inx 7591 7 depending depend VBG cord-010092-uftc8inx 7591 8 on on IN cord-010092-uftc8inx 7591 9 the the DT cord-010092-uftc8inx 7591 10 history history NN cord-010092-uftc8inx 7591 11 of of IN cord-010092-uftc8inx 7591 12 the the DT cord-010092-uftc8inx 7591 13 donor donor NN cord-010092-uftc8inx 7591 14 and and CC cord-010092-uftc8inx 7591 15 on on IN cord-010092-uftc8inx 7591 16 the the DT cord-010092-uftc8inx 7591 17 tissue tissue NN cord-010092-uftc8inx 7591 18 properties property NNS cord-010092-uftc8inx 7591 19 . . . cord-010092-uftc8inx 7592 1 Certain certain JJ cord-010092-uftc8inx 7592 2 grafts graft NNS cord-010092-uftc8inx 7592 3 can can MD cord-010092-uftc8inx 7592 4 be be VB cord-010092-uftc8inx 7592 5 donated donate VBN cord-010092-uftc8inx 7592 6 after after IN cord-010092-uftc8inx 7592 7 circulatory circulatory JJ cord-010092-uftc8inx 7592 8 death death NN cord-010092-uftc8inx 7592 9 of of IN cord-010092-uftc8inx 7592 10 the the DT cord-010092-uftc8inx 7592 11 donor donor NN cord-010092-uftc8inx 7592 12 ; ; : cord-010092-uftc8inx 7592 13 however however RB cord-010092-uftc8inx 7592 14 , , , cord-010092-uftc8inx 7592 15 the the DT cord-010092-uftc8inx 7592 16 absence absence NN cord-010092-uftc8inx 7592 17 of of IN cord-010092-uftc8inx 7592 18 the the DT cord-010092-uftc8inx 7592 19 heartbeat heartbeat NN cord-010092-uftc8inx 7592 20 may may MD cord-010092-uftc8inx 7592 21 change change VB cord-010092-uftc8inx 7592 22 dramatically dramatically RB cord-010092-uftc8inx 7592 23 the the DT cord-010092-uftc8inx 7592 24 blood blood NN cord-010092-uftc8inx 7592 25 composition composition NN cord-010092-uftc8inx 7592 26 by by IN cord-010092-uftc8inx 7592 27 e.g. e.g. RB cord-010092-uftc8inx 7592 28 , , , cord-010092-uftc8inx 7592 29 haemolysis haemolysis NN cord-010092-uftc8inx 7592 30 and and CC cord-010092-uftc8inx 7592 31 proteolysis proteolysis NN cord-010092-uftc8inx 7592 32 . . . cord-010092-uftc8inx 7593 1 This this DT cord-010092-uftc8inx 7593 2 may may MD cord-010092-uftc8inx 7593 3 have have VB cord-010092-uftc8inx 7593 4 an an DT cord-010092-uftc8inx 7593 5 impact impact NN cord-010092-uftc8inx 7593 6 on on IN cord-010092-uftc8inx 7593 7 test test NN cord-010092-uftc8inx 7593 8 performance performance NN cord-010092-uftc8inx 7593 9 and and CC cord-010092-uftc8inx 7593 10 lead lead VB cord-010092-uftc8inx 7593 11 to to IN cord-010092-uftc8inx 7593 12 false false JJ cord-010092-uftc8inx 7593 13 results result NNS cord-010092-uftc8inx 7593 14 . . . cord-010092-uftc8inx 7594 1 Therefore therefore RB cord-010092-uftc8inx 7594 2 , , , cord-010092-uftc8inx 7594 3 an an DT cord-010092-uftc8inx 7594 4 assay assay NN cord-010092-uftc8inx 7594 5 validation validation NN cord-010092-uftc8inx 7594 6 is be VBZ cord-010092-uftc8inx 7594 7 needed need VBN cord-010092-uftc8inx 7594 8 for for IN cord-010092-uftc8inx 7594 9 testing testing NN cord-010092-uftc8inx 7594 10 of of IN cord-010092-uftc8inx 7594 11 cadaveric cadaveric JJ cord-010092-uftc8inx 7594 12 samples sample NNS cord-010092-uftc8inx 7594 13 . . . cord-010092-uftc8inx 7595 1 Aims aim VBZ cord-010092-uftc8inx 7595 2 : : : cord-010092-uftc8inx 7595 3 A a DT cord-010092-uftc8inx 7595 4 validation validation NN cord-010092-uftc8inx 7595 5 study study NN cord-010092-uftc8inx 7595 6 was be VBD cord-010092-uftc8inx 7595 7 performed perform VBN cord-010092-uftc8inx 7595 8 to to TO cord-010092-uftc8inx 7595 9 demonstrate demonstrate VB cord-010092-uftc8inx 7595 10 the the DT cord-010092-uftc8inx 7595 11 suitability suitability NN cord-010092-uftc8inx 7595 12 of of IN cord-010092-uftc8inx 7595 13 Elecsys Elecsys NNP cord-010092-uftc8inx 7595 14 HBsAg HBsAg NNP cord-010092-uftc8inx 7595 15 II II NNP cord-010092-uftc8inx 7595 16 , , , cord-010092-uftc8inx 7595 17 Anti Anti NNP cord-010092-uftc8inx 7595 18 - - JJ cord-010092-uftc8inx 7595 19 HBc HBc NNP cord-010092-uftc8inx 7595 20 II II NNP cord-010092-uftc8inx 7595 21 , , , cord-010092-uftc8inx 7595 22 Anti Anti NNP cord-010092-uftc8inx 7595 23 - - NNP cord-010092-uftc8inx 7595 24 HCV HCV NNP cord-010092-uftc8inx 7595 25 II II NNP cord-010092-uftc8inx 7595 26 , , , cord-010092-uftc8inx 7595 27 HIV HIV NNP cord-010092-uftc8inx 7595 28 combi combi NN cord-010092-uftc8inx 7595 29 PT PT NNP cord-010092-uftc8inx 7595 30 , , , cord-010092-uftc8inx 7595 31 HIV HIV NNP cord-010092-uftc8inx 7595 32 Duo Duo NNP cord-010092-uftc8inx 7595 33 , , , cord-010092-uftc8inx 7595 34 Syphilis Syphilis NNP cord-010092-uftc8inx 7595 35 , , , cord-010092-uftc8inx 7595 36 HTLV HTLV NNP cord-010092-uftc8inx 7595 37 - - HYPH cord-010092-uftc8inx 7595 38 I I NNP cord-010092-uftc8inx 7595 39 / / SYM cord-010092-uftc8inx 7595 40 II II NNP cord-010092-uftc8inx 7595 41 , , , cord-010092-uftc8inx 7595 42 and and CC cord-010092-uftc8inx 7595 43 Chagas Chagas NNP cord-010092-uftc8inx 7595 44 for for IN cord-010092-uftc8inx 7595 45 the the DT cord-010092-uftc8inx 7595 46 use use NN cord-010092-uftc8inx 7595 47 in in IN cord-010092-uftc8inx 7595 48 cadaveric cadaveric JJ cord-010092-uftc8inx 7595 49 samples sample NNS cord-010092-uftc8inx 7595 50 from from IN cord-010092-uftc8inx 7595 51 non non JJ cord-010092-uftc8inx 7595 52 - - JJ cord-010092-uftc8inx 7595 53 heart heart JJ cord-010092-uftc8inx 7595 54 beating beat VBG cord-010092-uftc8inx 7595 55 donors donor NNS cord-010092-uftc8inx 7595 56 . . . cord-010092-uftc8inx 7596 1 Methods method NNS cord-010092-uftc8inx 7596 2 : : : cord-010092-uftc8inx 7597 1 As as IN cord-010092-uftc8inx 7597 2 the the DT cord-010092-uftc8inx 7597 3 basis basis NN cord-010092-uftc8inx 7597 4 for for IN cord-010092-uftc8inx 7597 5 validation validation NN cord-010092-uftc8inx 7597 6 , , , cord-010092-uftc8inx 7597 7 we -PRON- PRP cord-010092-uftc8inx 7597 8 followed follow VBD cord-010092-uftc8inx 7597 9 the the DT cord-010092-uftc8inx 7597 10 recommendations recommendation NNS cord-010092-uftc8inx 7597 11 of of IN cord-010092-uftc8inx 7597 12 the the DT cord-010092-uftc8inx 7597 13 Paul Paul NNP cord-010092-uftc8inx 7597 14 - - HYPH cord-010092-uftc8inx 7597 15 Ehrlich Ehrlich NNP cord-010092-uftc8inx 7597 16 - - HYPH cord-010092-uftc8inx 7597 17 Institut Institut NNP cord-010092-uftc8inx 7597 18 ( ( -LRB- cord-010092-uftc8inx 7597 19 PEI PEI NNP cord-010092-uftc8inx 7597 20 ) ) -RRB- cord-010092-uftc8inx 7598 1 " " `` cord-010092-uftc8inx 7598 2 Proposal proposal NN cord-010092-uftc8inx 7598 3 for for IN cord-010092-uftc8inx 7598 4 the the DT cord-010092-uftc8inx 7598 5 validation validation NN cord-010092-uftc8inx 7598 6 of of IN cord-010092-uftc8inx 7598 7 anti anti NN cord-010092-uftc8inx 7598 8 - - NN cord-010092-uftc8inx 7598 9 HIV-1/2 hiv-1/2 RB cord-010092-uftc8inx 7599 1 or or CC cord-010092-uftc8inx 7599 2 HIV HIV NNP cord-010092-uftc8inx 7599 3 Ag/ Ag/ NNP cord-010092-uftc8inx 7599 4 Ab Ab NNP cord-010092-uftc8inx 7599 5 combination combination NN cord-010092-uftc8inx 7599 6 assays assay NNS cord-010092-uftc8inx 7599 7 , , , cord-010092-uftc8inx 7599 8 anti anti JJ cord-010092-uftc8inx 7599 9 - - JJ cord-010092-uftc8inx 7599 10 HCV hcv JJ cord-010092-uftc8inx 7599 11 assays assay NNS cord-010092-uftc8inx 7599 12 , , , cord-010092-uftc8inx 7599 13 HBsAg hbsag ADD cord-010092-uftc8inx 7599 14 and and CC cord-010092-uftc8inx 7599 15 anti anti JJ cord-010092-uftc8inx 7599 16 - - JJ cord-010092-uftc8inx 7599 17 HBc hbc JJ cord-010092-uftc8inx 7599 18 assays assay NNS cord-010092-uftc8inx 7599 19 for for IN cord-010092-uftc8inx 7599 20 use use NN cord-010092-uftc8inx 7599 21 with with IN cord-010092-uftc8inx 7599 22 cadaveric cadaveric JJ cord-010092-uftc8inx 7599 23 samples sample NNS cord-010092-uftc8inx 7599 24 " " '' cord-010092-uftc8inx 7599 25 . . . cord-010092-uftc8inx 7600 1 Comparison comparison NN cord-010092-uftc8inx 7600 2 of of IN cord-010092-uftc8inx 7600 3 spiked spiked JJ cord-010092-uftc8inx 7600 4 samples sample NNS cord-010092-uftc8inx 7600 5 from from IN cord-010092-uftc8inx 7600 6 living live VBG cord-010092-uftc8inx 7600 7 donors donor NNS cord-010092-uftc8inx 7600 8 and and CC cord-010092-uftc8inx 7600 9 cadaveric cadaveric JJ cord-010092-uftc8inx 7600 10 donors donor NNS cord-010092-uftc8inx 7600 11 was be VBD cord-010092-uftc8inx 7600 12 used use VBN cord-010092-uftc8inx 7600 13 to to TO cord-010092-uftc8inx 7600 14 demonstrate demonstrate VB cord-010092-uftc8inx 7600 15 accuracy accuracy NN cord-010092-uftc8inx 7600 16 . . . cord-010092-uftc8inx 7601 1 To to TO cord-010092-uftc8inx 7601 2 determine determine VB cord-010092-uftc8inx 7601 3 precision precision NN cord-010092-uftc8inx 7601 4 , , , cord-010092-uftc8inx 7601 5 two two CD cord-010092-uftc8inx 7601 6 cadaveric cadaveric JJ cord-010092-uftc8inx 7601 7 specimens specimen NNS cord-010092-uftc8inx 7601 8 were be VBD cord-010092-uftc8inx 7601 9 tested test VBN cord-010092-uftc8inx 7601 10 in in IN cord-010092-uftc8inx 7601 11 several several JJ cord-010092-uftc8inx 7601 12 replicates replicate NNS cord-010092-uftc8inx 7601 13 . . . cord-010092-uftc8inx 7602 1 Acceptance acceptance NN cord-010092-uftc8inx 7602 2 criteria criterion NNS cord-010092-uftc8inx 7602 3 were be VBD cord-010092-uftc8inx 7602 4 implemented implement VBN cord-010092-uftc8inx 7602 5 according accord VBG cord-010092-uftc8inx 7602 6 to to IN cord-010092-uftc8inx 7602 7 the the DT cord-010092-uftc8inx 7602 8 PEI PEI NNP cord-010092-uftc8inx 7602 9 recommendations recommendation NNS cord-010092-uftc8inx 7602 10 . . . cord-010092-uftc8inx 7603 1 Results result NNS cord-010092-uftc8inx 7603 2 : : : cord-010092-uftc8inx 7604 1 Results result NNS cord-010092-uftc8inx 7604 2 were be VBD cord-010092-uftc8inx 7604 3 found find VBN cord-010092-uftc8inx 7604 4 to to TO cord-010092-uftc8inx 7604 5 be be VB cord-010092-uftc8inx 7604 6 within within IN cord-010092-uftc8inx 7604 7 specifications specification NNS cord-010092-uftc8inx 7604 8 requested request VBN cord-010092-uftc8inx 7604 9 by by IN cord-010092-uftc8inx 7604 10 the the DT cord-010092-uftc8inx 7604 11 PEI PEI NNP cord-010092-uftc8inx 7604 12 recommendations recommendation NNS cord-010092-uftc8inx 7604 13 for for IN cord-010092-uftc8inx 7604 14 all all DT cord-010092-uftc8inx 7604 15 tested test VBN cord-010092-uftc8inx 7604 16 assays assay NNS cord-010092-uftc8inx 7604 17 Summary Summary NNP cord-010092-uftc8inx 7604 18 / / SYM cord-010092-uftc8inx 7604 19 Conclusions Conclusions NNPS cord-010092-uftc8inx 7604 20 : : : cord-010092-uftc8inx 7605 1 The the DT cord-010092-uftc8inx 7605 2 evaluated evaluate VBN cord-010092-uftc8inx 7605 3 results result NNS cord-010092-uftc8inx 7605 4 support support VBP cord-010092-uftc8inx 7605 5 the the DT cord-010092-uftc8inx 7605 6 extension extension NN cord-010092-uftc8inx 7605 7 of of IN cord-010092-uftc8inx 7605 8 the the DT cord-010092-uftc8inx 7605 9 use use NN cord-010092-uftc8inx 7605 10 of of IN cord-010092-uftc8inx 7605 11 these these DT cord-010092-uftc8inx 7605 12 assays assay NNS cord-010092-uftc8inx 7605 13 with with IN cord-010092-uftc8inx 7605 14 cadaveric cadaveric JJ cord-010092-uftc8inx 7605 15 specimens specimen NNS cord-010092-uftc8inx 7605 16 . . . cord-010092-uftc8inx 7606 1 Background background NN cord-010092-uftc8inx 7606 2 : : : cord-010092-uftc8inx 7607 1 In in IN cord-010092-uftc8inx 7607 2 developed develop VBN cord-010092-uftc8inx 7607 3 countries country NNS cord-010092-uftc8inx 7607 4 , , , cord-010092-uftc8inx 7607 5 blood blood NN cord-010092-uftc8inx 7607 6 donors donor NNS cord-010092-uftc8inx 7607 7 are be VBP cord-010092-uftc8inx 7607 8 routinely routinely RB cord-010092-uftc8inx 7607 9 screened screen VBN cord-010092-uftc8inx 7607 10 for for IN cord-010092-uftc8inx 7607 11 a a DT cord-010092-uftc8inx 7607 12 range range NN cord-010092-uftc8inx 7607 13 of of IN cord-010092-uftc8inx 7607 14 blood blood NN cord-010092-uftc8inx 7607 15 borne bear VBN cord-010092-uftc8inx 7607 16 viruses virus NNS cord-010092-uftc8inx 7607 17 ( ( -LRB- cord-010092-uftc8inx 7607 18 HIV HIV NNP cord-010092-uftc8inx 7607 19 , , , cord-010092-uftc8inx 7607 20 HBV HBV NNP cord-010092-uftc8inx 7607 21 , , , cord-010092-uftc8inx 7607 22 HCV HCV NNP cord-010092-uftc8inx 7607 23 and and CC cord-010092-uftc8inx 7607 24 HTLV HTLV NNP cord-010092-uftc8inx 7607 25 ) ) -RRB- cord-010092-uftc8inx 7607 26 using use VBG cord-010092-uftc8inx 7607 27 highly highly RB cord-010092-uftc8inx 7607 28 sensitive sensitive JJ cord-010092-uftc8inx 7607 29 screening screening NN cord-010092-uftc8inx 7607 30 tests test NNS cord-010092-uftc8inx 7607 31 . . . cord-010092-uftc8inx 7608 1 This this DT cord-010092-uftc8inx 7608 2 has have VBZ cord-010092-uftc8inx 7608 3 dramatically dramatically RB cord-010092-uftc8inx 7608 4 improved improve VBN cord-010092-uftc8inx 7608 5 the the DT cord-010092-uftc8inx 7608 6 safety safety NN cord-010092-uftc8inx 7608 7 of of IN cord-010092-uftc8inx 7608 8 blood blood NN cord-010092-uftc8inx 7608 9 supply supply NN cord-010092-uftc8inx 7608 10 . . . cord-010092-uftc8inx 7609 1 However however RB cord-010092-uftc8inx 7609 2 , , , cord-010092-uftc8inx 7609 3 transmission transmission NN cord-010092-uftc8inx 7609 4 by by IN cord-010092-uftc8inx 7609 5 transfusion transfusion NN cord-010092-uftc8inx 7609 6 of of IN cord-010092-uftc8inx 7609 7 unknown unknown JJ cord-010092-uftc8inx 7609 8 or or CC cord-010092-uftc8inx 7609 9 unsuspected unsuspected JJ cord-010092-uftc8inx 7609 10 viruses virus NNS cord-010092-uftc8inx 7609 11 remains remain VBZ cord-010092-uftc8inx 7609 12 a a DT cord-010092-uftc8inx 7609 13 continuing continue VBG cord-010092-uftc8inx 7609 14 threat threat NN cord-010092-uftc8inx 7609 15 . . . cord-010092-uftc8inx 7610 1 This this DT cord-010092-uftc8inx 7610 2 is be VBZ cord-010092-uftc8inx 7610 3 particularly particularly RB cord-010092-uftc8inx 7610 4 relevant relevant JJ cord-010092-uftc8inx 7610 5 considering considering NN cord-010092-uftc8inx 7610 6 that that IN cord-010092-uftc8inx 7610 7 a a DT cord-010092-uftc8inx 7610 8 significant significant JJ cord-010092-uftc8inx 7610 9 proportion proportion NN cord-010092-uftc8inx 7610 10 of of IN cord-010092-uftc8inx 7610 11 transfused transfuse VBN cord-010092-uftc8inx 7610 12 patients patient NNS cord-010092-uftc8inx 7610 13 are be VBP cord-010092-uftc8inx 7610 14 immunocompromised immunocompromised JJ cord-010092-uftc8inx 7610 15 and and CC cord-010092-uftc8inx 7610 16 more more RBR cord-010092-uftc8inx 7610 17 frequently frequently RB cord-010092-uftc8inx 7610 18 subjected subject VBN cord-010092-uftc8inx 7610 19 to to IN cord-010092-uftc8inx 7610 20 fatal fatal JJ cord-010092-uftc8inx 7610 21 outcomes outcome NNS cord-010092-uftc8inx 7610 22 . . . cord-010092-uftc8inx 7611 1 In in IN cord-010092-uftc8inx 7611 2 developed develop VBN cord-010092-uftc8inx 7611 3 countries country NNS cord-010092-uftc8inx 7611 4 , , , cord-010092-uftc8inx 7611 5 blood blood NN cord-010092-uftc8inx 7611 6 donors donor NNS cord-010092-uftc8inx 7611 7 are be VBP cord-010092-uftc8inx 7611 8 routinely routinely RB cord-010092-uftc8inx 7611 9 screened screen VBN cord-010092-uftc8inx 7611 10 for for IN cord-010092-uftc8inx 7611 11 a a DT cord-010092-uftc8inx 7611 12 range range NN cord-010092-uftc8inx 7611 13 of of IN cord-010092-uftc8inx 7611 14 blood blood NN cord-010092-uftc8inx 7611 15 borne bear VBN cord-010092-uftc8inx 7611 16 viruses virus NNS cord-010092-uftc8inx 7611 17 ( ( -LRB- cord-010092-uftc8inx 7611 18 HIV HIV NNP cord-010092-uftc8inx 7611 19 , , , cord-010092-uftc8inx 7611 20 HBV HBV NNP cord-010092-uftc8inx 7611 21 , , , cord-010092-uftc8inx 7611 22 HCV HCV NNP cord-010092-uftc8inx 7611 23 and and CC cord-010092-uftc8inx 7611 24 HTLV HTLV NNP cord-010092-uftc8inx 7611 25 ) ) -RRB- cord-010092-uftc8inx 7611 26 using use VBG cord-010092-uftc8inx 7611 27 highly highly RB cord-010092-uftc8inx 7611 28 sensitive sensitive JJ cord-010092-uftc8inx 7611 29 screening screening NN cord-010092-uftc8inx 7611 30 tests test NNS cord-010092-uftc8inx 7611 31 . . . cord-010092-uftc8inx 7612 1 This this DT cord-010092-uftc8inx 7612 2 has have VBZ cord-010092-uftc8inx 7612 3 dramatically dramatically RB cord-010092-uftc8inx 7612 4 improved improve VBN cord-010092-uftc8inx 7612 5 the the DT cord-010092-uftc8inx 7612 6 safety safety NN cord-010092-uftc8inx 7612 7 of of IN cord-010092-uftc8inx 7612 8 blood blood NN cord-010092-uftc8inx 7612 9 supply supply NN cord-010092-uftc8inx 7612 10 . . . cord-010092-uftc8inx 7613 1 However however RB cord-010092-uftc8inx 7613 2 , , , cord-010092-uftc8inx 7613 3 transmission transmission NN cord-010092-uftc8inx 7613 4 by by IN cord-010092-uftc8inx 7613 5 transfusion transfusion NN cord-010092-uftc8inx 7613 6 of of IN cord-010092-uftc8inx 7613 7 unknown unknown JJ cord-010092-uftc8inx 7613 8 or or CC cord-010092-uftc8inx 7613 9 unsuspected unsuspected JJ cord-010092-uftc8inx 7613 10 viruses virus NNS cord-010092-uftc8inx 7613 11 remains remain VBZ cord-010092-uftc8inx 7613 12 a a DT cord-010092-uftc8inx 7613 13 continuing continue VBG cord-010092-uftc8inx 7613 14 threat threat NN cord-010092-uftc8inx 7613 15 . . . cord-010092-uftc8inx 7614 1 This this DT cord-010092-uftc8inx 7614 2 is be VBZ cord-010092-uftc8inx 7614 3 particularly particularly RB cord-010092-uftc8inx 7614 4 relevant relevant JJ cord-010092-uftc8inx 7614 5 considering considering NN cord-010092-uftc8inx 7614 6 that that IN cord-010092-uftc8inx 7614 7 a a DT cord-010092-uftc8inx 7614 8 significant significant JJ cord-010092-uftc8inx 7614 9 proportion proportion NN cord-010092-uftc8inx 7614 10 of of IN cord-010092-uftc8inx 7614 11 transfused transfuse VBN cord-010092-uftc8inx 7614 12 patients patient NNS cord-010092-uftc8inx 7614 13 are be VBP cord-010092-uftc8inx 7614 14 immunocompromised immunocompromised JJ cord-010092-uftc8inx 7614 15 and and CC cord-010092-uftc8inx 7614 16 more more RBR cord-010092-uftc8inx 7614 17 frequently frequently RB cord-010092-uftc8inx 7614 18 subjected subject VBN cord-010092-uftc8inx 7614 19 to to IN cord-010092-uftc8inx 7614 20 fatal fatal JJ cord-010092-uftc8inx 7614 21 outcomes outcome NNS cord-010092-uftc8inx 7614 22 . . . cord-010092-uftc8inx 7615 1 Aims aim VBZ cord-010092-uftc8inx 7615 2 : : : cord-010092-uftc8inx 7616 1 In in IN cord-010092-uftc8inx 7616 2 this this DT cord-010092-uftc8inx 7616 3 context context NN cord-010092-uftc8inx 7616 4 , , , cord-010092-uftc8inx 7616 5 metagenomic metagenomic JJ cord-010092-uftc8inx 7616 6 analyses analysis NNS cord-010092-uftc8inx 7616 7 of of IN cord-010092-uftc8inx 7616 8 viral viral JJ cord-010092-uftc8inx 7616 9 content content NN cord-010092-uftc8inx 7616 10 in in IN cord-010092-uftc8inx 7616 11 blood blood NN cord-010092-uftc8inx 7616 12 donations donation NNS cord-010092-uftc8inx 7616 13 collected collect VBN cord-010092-uftc8inx 7616 14 in in IN cord-010092-uftc8inx 7616 15 geographical geographical JJ cord-010092-uftc8inx 7616 16 zones zone NNS cord-010092-uftc8inx 7616 17 recognized recognize VBN cord-010092-uftc8inx 7616 18 as as IN cord-010092-uftc8inx 7616 19 " " `` cord-010092-uftc8inx 7616 20 hotspot hotspot NN cord-010092-uftc8inx 7616 21 " " '' cord-010092-uftc8inx 7616 22 for for IN cord-010092-uftc8inx 7616 23 viral viral JJ cord-010092-uftc8inx 7616 24 emergence emergence NN cord-010092-uftc8inx 7616 25 represents represent VBZ cord-010092-uftc8inx 7616 26 a a DT cord-010092-uftc8inx 7616 27 suitable suitable JJ cord-010092-uftc8inx 7616 28 approach approach NN cord-010092-uftc8inx 7616 29 without without IN cord-010092-uftc8inx 7616 30 any any DT cord-010092-uftc8inx 7616 31 a a FW cord-010092-uftc8inx 7616 32 priori priori NN cord-010092-uftc8inx 7616 33 for for IN cord-010092-uftc8inx 7616 34 the the DT cord-010092-uftc8inx 7616 35 identification identification NN cord-010092-uftc8inx 7616 36 of of IN cord-010092-uftc8inx 7616 37 a a DT cord-010092-uftc8inx 7616 38 potential potential JJ cord-010092-uftc8inx 7616 39 emerging emerge VBG cord-010092-uftc8inx 7616 40 viral viral JJ cord-010092-uftc8inx 7616 41 risk risk NN cord-010092-uftc8inx 7616 42 that that WDT cord-010092-uftc8inx 7616 43 may may MD cord-010092-uftc8inx 7616 44 compromise compromise VB cord-010092-uftc8inx 7616 45 blood blood NN cord-010092-uftc8inx 7616 46 safety safety NN cord-010092-uftc8inx 7616 47 . . . cord-010092-uftc8inx 7617 1 Methods method NNS cord-010092-uftc8inx 7617 2 : : : cord-010092-uftc8inx 7617 3 In in IN cord-010092-uftc8inx 7617 4 the the DT cord-010092-uftc8inx 7617 5 framework framework NN cord-010092-uftc8inx 7617 6 of of IN cord-010092-uftc8inx 7617 7 a a DT cord-010092-uftc8inx 7617 8 viral viral JJ cord-010092-uftc8inx 7617 9 discovery discovery NN cord-010092-uftc8inx 7617 10 program program NN cord-010092-uftc8inx 7617 11 founded found VBN cord-010092-uftc8inx 7617 12 by by IN cord-010092-uftc8inx 7617 13 the the DT cord-010092-uftc8inx 7617 14 French French NNP cord-010092-uftc8inx 7617 15 National National NNP cord-010092-uftc8inx 7617 16 Agency Agency NNP cord-010092-uftc8inx 7617 17 for for IN cord-010092-uftc8inx 7617 18 Medicine Medicine NNP cord-010092-uftc8inx 7617 19 Security Security NNP cord-010092-uftc8inx 7617 20 ( ( -LRB- cord-010092-uftc8inx 7617 21 ANSM ANSM NNP cord-010092-uftc8inx 7617 22 in in IN cord-010092-uftc8inx 7617 23 French French NNP cord-010092-uftc8inx 7617 24 ) ) -RRB- cord-010092-uftc8inx 7617 25 , , , cord-010092-uftc8inx 7617 26 more more JJR cord-010092-uftc8inx 7617 27 than than IN cord-010092-uftc8inx 7617 28 900 900 CD cord-010092-uftc8inx 7617 29 plasma plasma NN cord-010092-uftc8inx 7617 30 samples sample NNS cord-010092-uftc8inx 7617 31 collected collect VBN cord-010092-uftc8inx 7617 32 in in IN cord-010092-uftc8inx 7617 33 7 7 CD cord-010092-uftc8inx 7617 34 sub sub JJ cord-010092-uftc8inx 7617 35 - - JJ cord-010092-uftc8inx 7617 36 Saharan Saharan NNP cord-010092-uftc8inx 7617 37 Africa Africa NNP cord-010092-uftc8inx 7617 38 countries country NNS cord-010092-uftc8inx 7617 39 ( ( -LRB- cord-010092-uftc8inx 7617 40 2011 2011 CD cord-010092-uftc8inx 7617 41 ) ) -RRB- cord-010092-uftc8inx 7617 42 ( ( -LRB- cord-010092-uftc8inx 7617 43 2012 2012 CD cord-010092-uftc8inx 7617 44 ) ) -RRB- cord-010092-uftc8inx 7617 45 and and CC cord-010092-uftc8inx 7617 46 the the DT cord-010092-uftc8inx 7617 47 Amazon Amazon NNP cord-010092-uftc8inx 7617 48 region region NN cord-010092-uftc8inx 7617 49 of of IN cord-010092-uftc8inx 7617 50 Brazil Brazil NNP cord-010092-uftc8inx 7617 51 ( ( -LRB- cord-010092-uftc8inx 7617 52 2016 2016 CD cord-010092-uftc8inx 7617 53 ) ) -RRB- cord-010092-uftc8inx 7617 54 have have VBP cord-010092-uftc8inx 7617 55 already already RB cord-010092-uftc8inx 7617 56 been be VBN cord-010092-uftc8inx 7617 57 analysed analyse VBN cord-010092-uftc8inx 7617 58 by by IN cord-010092-uftc8inx 7617 59 metagenomics metagenomic NNS cord-010092-uftc8inx 7617 60 . . . cord-010092-uftc8inx 7618 1 Results result NNS cord-010092-uftc8inx 7618 2 : : : cord-010092-uftc8inx 7619 1 Although although IN cord-010092-uftc8inx 7619 2 no no DT cord-010092-uftc8inx 7619 3 viral viral JJ cord-010092-uftc8inx 7619 4 sequence sequence NN cord-010092-uftc8inx 7619 5 could could MD cord-010092-uftc8inx 7619 6 be be VB cord-010092-uftc8inx 7619 7 described describe VBN cord-010092-uftc8inx 7619 8 as as IN cord-010092-uftc8inx 7619 9 novel novel NN cord-010092-uftc8inx 7619 10 ( ( -LRB- cord-010092-uftc8inx 7619 11 i.e. i.e. FW cord-010092-uftc8inx 7619 12 new new JJ cord-010092-uftc8inx 7619 13 species specie NNS cord-010092-uftc8inx 7619 14 or or CC cord-010092-uftc8inx 7619 15 even even RB cord-010092-uftc8inx 7619 16 a a DT cord-010092-uftc8inx 7619 17 new new JJ cord-010092-uftc8inx 7619 18 genus genus NN cord-010092-uftc8inx 7619 19 ) ) -RRB- cord-010092-uftc8inx 7619 20 , , , cord-010092-uftc8inx 7619 21 we -PRON- PRP cord-010092-uftc8inx 7619 22 unexpectedly unexpectedly RB cord-010092-uftc8inx 7619 23 identified identify VBD cord-010092-uftc8inx 7619 24 a a DT cord-010092-uftc8inx 7619 25 Feline Feline NNP cord-010092-uftc8inx 7619 26 Bocavirus Bocavirus NNP cord-010092-uftc8inx 7619 27 in in IN cord-010092-uftc8inx 7619 28 two two CD cord-010092-uftc8inx 7619 29 donors donor NNS cord-010092-uftc8inx 7619 30 from from IN cord-010092-uftc8inx 7619 31 Mauritania Mauritania NNP cord-010092-uftc8inx 7619 32 . . . cord-010092-uftc8inx 7620 1 A a DT cord-010092-uftc8inx 7620 2 large large JJ cord-010092-uftc8inx 7620 3 diversity diversity NN cord-010092-uftc8inx 7620 4 of of IN cord-010092-uftc8inx 7620 5 known know VBN cord-010092-uftc8inx 7620 6 viruses virus NNS cord-010092-uftc8inx 7620 7 that that WDT cord-010092-uftc8inx 7620 8 are be VBP cord-010092-uftc8inx 7620 9 not not RB cord-010092-uftc8inx 7620 10 part part NN cord-010092-uftc8inx 7620 11 of of IN cord-010092-uftc8inx 7620 12 the the DT cord-010092-uftc8inx 7620 13 regularly regularly RB cord-010092-uftc8inx 7620 14 monitored monitor VBN cord-010092-uftc8inx 7620 15 agents agent NNS cord-010092-uftc8inx 7620 16 were be VBD cord-010092-uftc8inx 7620 17 also also RB cord-010092-uftc8inx 7620 18 observed observe VBN cord-010092-uftc8inx 7620 19 , , , cord-010092-uftc8inx 7620 20 among among IN cord-010092-uftc8inx 7620 21 which which WDT cord-010092-uftc8inx 7620 22 Anelloviruses Anelloviruses NNP cord-010092-uftc8inx 7620 23 , , , cord-010092-uftc8inx 7620 24 HPgV-1 HPgV-1 NNP cord-010092-uftc8inx 7620 25 ( ( -LRB- cord-010092-uftc8inx 7620 26 formerly formerly RB cord-010092-uftc8inx 7620 27 known know VBN cord-010092-uftc8inx 7620 28 as as IN cord-010092-uftc8inx 7620 29 GBV GBV NNP cord-010092-uftc8inx 7620 30 - - HYPH cord-010092-uftc8inx 7620 31 C C NNP cord-010092-uftc8inx 7620 32 ) ) -RRB- cord-010092-uftc8inx 7620 33 , , , cord-010092-uftc8inx 7620 34 Papillomaviruses Papillomaviruses NNP cord-010092-uftc8inx 7620 35 , , , cord-010092-uftc8inx 7620 36 Herpes Herpes NNP cord-010092-uftc8inx 7620 37 viruses virus NNS cord-010092-uftc8inx 7620 38 , , , cord-010092-uftc8inx 7620 39 Parvovirus Parvovirus NNP cord-010092-uftc8inx 7620 40 B19 B19 NNP cord-010092-uftc8inx 7620 41 , , , cord-010092-uftc8inx 7620 42 Chikungunya chikungunya NN cord-010092-uftc8inx 7620 43 virus virus NN cord-010092-uftc8inx 7620 44 , , , cord-010092-uftc8inx 7620 45 Enterovirus enterovirus NN cord-010092-uftc8inx 7620 46 , , , cord-010092-uftc8inx 7620 47 and and CC cord-010092-uftc8inx 7620 48 various various JJ cord-010092-uftc8inx 7620 49 small small JJ cord-010092-uftc8inx 7620 50 circular circular JJ cord-010092-uftc8inx 7620 51 viruses virus NNS cord-010092-uftc8inx 7620 52 ( ( -LRB- cord-010092-uftc8inx 7620 53 circo- circo- FW cord-010092-uftc8inx 7620 54 , , , cord-010092-uftc8inx 7620 55 cycloand cycloand NNP cord-010092-uftc8inx 7620 56 gemycircularviruses gemycircularviruses NNP cord-010092-uftc8inx 7620 57 ) ) -RRB- cord-010092-uftc8inx 7620 58 . . . cord-010092-uftc8inx 7621 1 While while IN cord-010092-uftc8inx 7621 2 no no DT cord-010092-uftc8inx 7621 3 significative significative JJ cord-010092-uftc8inx 7621 4 differences difference NNS cord-010092-uftc8inx 7621 5 was be VBD cord-010092-uftc8inx 7621 6 observed observe VBN cord-010092-uftc8inx 7621 7 in in IN cord-010092-uftc8inx 7621 8 the the DT cord-010092-uftc8inx 7621 9 higher high JJR cord-010092-uftc8inx 7621 10 classification classification NN cord-010092-uftc8inx 7621 11 of of IN cord-010092-uftc8inx 7621 12 detected detect VBN cord-010092-uftc8inx 7621 13 virus virus NN cord-010092-uftc8inx 7621 14 ( ( -LRB- cord-010092-uftc8inx 7621 15 above above IN cord-010092-uftc8inx 7621 16 families family NNS cord-010092-uftc8inx 7621 17 / / , cord-010092-uftc8inx 7621 18 genera genus NNS cord-010092-uftc8inx 7621 19 ) ) -RRB- cord-010092-uftc8inx 7621 20 between between IN cord-010092-uftc8inx 7621 21 Africa Africa NNP cord-010092-uftc8inx 7621 22 and and CC cord-010092-uftc8inx 7621 23 Brazil Brazil NNP cord-010092-uftc8inx 7621 24 , , , cord-010092-uftc8inx 7621 25 we -PRON- PRP cord-010092-uftc8inx 7621 26 observed observe VBD cord-010092-uftc8inx 7621 27 variations variation NNS cord-010092-uftc8inx 7621 28 at at IN cord-010092-uftc8inx 7621 29 the the DT cord-010092-uftc8inx 7621 30 sequence sequence NN cord-010092-uftc8inx 7621 31 level level NN cord-010092-uftc8inx 7621 32 allowing allow VBG cord-010092-uftc8inx 7621 33 better well JJR cord-010092-uftc8inx 7621 34 resolution resolution NN cord-010092-uftc8inx 7621 35 of of IN cord-010092-uftc8inx 7621 36 the the DT cord-010092-uftc8inx 7621 37 genetic genetic JJ cord-010092-uftc8inx 7621 38 diversity diversity NN cord-010092-uftc8inx 7621 39 for for IN cord-010092-uftc8inx 7621 40 several several JJ cord-010092-uftc8inx 7621 41 viruses virus NNS cord-010092-uftc8inx 7621 42 ( ( -LRB- cord-010092-uftc8inx 7621 43 for for IN cord-010092-uftc8inx 7621 44 example example NN cord-010092-uftc8inx 7621 45 characterization characterization NN cord-010092-uftc8inx 7621 46 of of IN cord-010092-uftc8inx 7621 47 HPgV-1 HPgV-1 NNP cord-010092-uftc8inx 7621 48 genotypes genotype NNS cord-010092-uftc8inx 7621 49 ) ) -RRB- cord-010092-uftc8inx 7621 50 . . . cord-010092-uftc8inx 7622 1 Summary Summary NNP cord-010092-uftc8inx 7622 2 / / SYM cord-010092-uftc8inx 7622 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 7622 4 : : : cord-010092-uftc8inx 7623 1 Overall overall RB cord-010092-uftc8inx 7623 2 , , , cord-010092-uftc8inx 7623 3 the the DT cord-010092-uftc8inx 7623 4 absence absence NN cord-010092-uftc8inx 7623 5 of of IN cord-010092-uftc8inx 7623 6 novel novel NN cord-010092-uftc8inx 7623 7 viruses virus NNS cord-010092-uftc8inx 7623 8 in in IN cord-010092-uftc8inx 7623 9 blood blood NN cord-010092-uftc8inx 7623 10 samples sample NNS cord-010092-uftc8inx 7623 11 collected collect VBN cord-010092-uftc8inx 7623 12 across across IN cord-010092-uftc8inx 7623 13 countries country NNS cord-010092-uftc8inx 7623 14 of of IN cord-010092-uftc8inx 7623 15 two two CD cord-010092-uftc8inx 7623 16 distant distant JJ cord-010092-uftc8inx 7623 17 continents continent NNS cord-010092-uftc8inx 7623 18 is be VBZ cord-010092-uftc8inx 7623 19 reassuring reassure VBG cord-010092-uftc8inx 7623 20 regarding regard VBG cord-010092-uftc8inx 7623 21 threats threat NNS cord-010092-uftc8inx 7623 22 emergence emergence NN cord-010092-uftc8inx 7623 23 . . . cord-010092-uftc8inx 7624 1 However however RB cord-010092-uftc8inx 7624 2 , , , cord-010092-uftc8inx 7624 3 continuous continuous JJ cord-010092-uftc8inx 7624 4 monitoring monitoring NN cord-010092-uftc8inx 7624 5 of of IN cord-010092-uftc8inx 7624 6 prospective prospective JJ cord-010092-uftc8inx 7624 7 blood blood NN cord-010092-uftc8inx 7624 8 banks bank NNS cord-010092-uftc8inx 7624 9 should should MD cord-010092-uftc8inx 7624 10 be be VB cord-010092-uftc8inx 7624 11 continued continue VBN cord-010092-uftc8inx 7624 12 . . . cord-010092-uftc8inx 7625 1 Summary Summary NNP cord-010092-uftc8inx 7625 2 / / SYM cord-010092-uftc8inx 7625 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 7625 4 : : : cord-010092-uftc8inx 7626 1 After after IN cord-010092-uftc8inx 7626 2 the the DT cord-010092-uftc8inx 7626 3 high high JJ cord-010092-uftc8inx 7626 4 peak peak NN cord-010092-uftc8inx 7626 5 observed observe VBD cord-010092-uftc8inx 7626 6 in in IN cord-010092-uftc8inx 7626 7 2014 2014 CD cord-010092-uftc8inx 7626 8 during during IN cord-010092-uftc8inx 7626 9 the the DT cord-010092-uftc8inx 7626 10 first first JJ cord-010092-uftc8inx 7626 11 period period NN cord-010092-uftc8inx 7626 12 , , , cord-010092-uftc8inx 7626 13 this this DT cord-010092-uftc8inx 7626 14 study study NN cord-010092-uftc8inx 7626 15 shows show VBZ cord-010092-uftc8inx 7626 16 that that IN cord-010092-uftc8inx 7626 17 the the DT cord-010092-uftc8inx 7626 18 decrease decrease NN cord-010092-uftc8inx 7626 19 in in IN cord-010092-uftc8inx 7626 20 the the DT cord-010092-uftc8inx 7626 21 seroprevalence seroprevalence NN cord-010092-uftc8inx 7626 22 of of IN cord-010092-uftc8inx 7626 23 viral viral JJ cord-010092-uftc8inx 7626 24 markers marker NNS cord-010092-uftc8inx 7626 25 is be VBZ cord-010092-uftc8inx 7626 26 continuous continuous JJ cord-010092-uftc8inx 7626 27 over over IN cord-010092-uftc8inx 7626 28 the the DT cord-010092-uftc8inx 7626 29 next next JJ cord-010092-uftc8inx 7626 30 five five CD cord-010092-uftc8inx 7626 31 years year NNS cord-010092-uftc8inx 7626 32 . . . cord-010092-uftc8inx 7627 1 The the DT cord-010092-uftc8inx 7627 2 second second JJ cord-010092-uftc8inx 7627 3 period period NN cord-010092-uftc8inx 7627 4 is be VBZ cord-010092-uftc8inx 7627 5 marked mark VBN cord-010092-uftc8inx 7627 6 by by IN cord-010092-uftc8inx 7627 7 an an DT cord-010092-uftc8inx 7627 8 irregular irregular JJ cord-010092-uftc8inx 7627 9 evolution evolution NN cord-010092-uftc8inx 7627 10 of of IN cord-010092-uftc8inx 7627 11 seroprevalence seroprevalence NN cord-010092-uftc8inx 7627 12 but but CC cord-010092-uftc8inx 7627 13 with with IN cord-010092-uftc8inx 7627 14 lower low JJR cord-010092-uftc8inx 7627 15 levels level NNS cord-010092-uftc8inx 7627 16 than than IN cord-010092-uftc8inx 7627 17 the the DT cord-010092-uftc8inx 7627 18 first first JJ cord-010092-uftc8inx 7627 19 period period NN cord-010092-uftc8inx 7627 20 . . . cord-010092-uftc8inx 7628 1 The the DT cord-010092-uftc8inx 7628 2 recruitment recruitment NN cord-010092-uftc8inx 7628 3 of of IN cord-010092-uftc8inx 7628 4 new new JJ cord-010092-uftc8inx 7628 5 donors donor NNS cord-010092-uftc8inx 7628 6 allows allow VBZ cord-010092-uftc8inx 7628 7 a a DT cord-010092-uftc8inx 7628 8 quantitative quantitative JJ cord-010092-uftc8inx 7628 9 increase increase NN cord-010092-uftc8inx 7628 10 in in IN cord-010092-uftc8inx 7628 11 donations donation NNS cord-010092-uftc8inx 7628 12 . . . cord-010092-uftc8inx 7629 1 However however RB cord-010092-uftc8inx 7629 2 , , , cord-010092-uftc8inx 7629 3 improving improve VBG cord-010092-uftc8inx 7629 4 the the DT cord-010092-uftc8inx 7629 5 quality quality NN cord-010092-uftc8inx 7629 6 of of IN cord-010092-uftc8inx 7629 7 blood blood NN cord-010092-uftc8inx 7629 8 products product NNS cord-010092-uftc8inx 7629 9 essential essential JJ cord-010092-uftc8inx 7629 10 condition condition NN cord-010092-uftc8inx 7629 11 of of IN cord-010092-uftc8inx 7629 12 transfusion transfusion NN cord-010092-uftc8inx 7629 13 safety safety NN cord-010092-uftc8inx 7629 14 is be VBZ cord-010092-uftc8inx 7629 15 achieved achieve VBN cord-010092-uftc8inx 7629 16 through through IN cord-010092-uftc8inx 7629 17 retention retention NN cord-010092-uftc8inx 7629 18 of of IN cord-010092-uftc8inx 7629 19 recruited recruit VBN cord-010092-uftc8inx 7629 20 blood blood NN cord-010092-uftc8inx 7629 21 donors donor NNS cord-010092-uftc8inx 7629 22 . . . cord-010092-uftc8inx 7630 1 Background background NN cord-010092-uftc8inx 7630 2 : : : cord-010092-uftc8inx 7631 1 In in IN cord-010092-uftc8inx 7631 2 blood blood NN cord-010092-uftc8inx 7631 3 screening screening NN cord-010092-uftc8inx 7631 4 laboratories laboratory NNS cord-010092-uftc8inx 7631 5 , , , cord-010092-uftc8inx 7631 6 samples sample NNS cord-010092-uftc8inx 7631 7 may may MD cord-010092-uftc8inx 7631 8 be be VB cord-010092-uftc8inx 7631 9 transferred transfer VBN cord-010092-uftc8inx 7631 10 between between IN cord-010092-uftc8inx 7631 11 automated automated JJ cord-010092-uftc8inx 7631 12 serological serological JJ cord-010092-uftc8inx 7631 13 and and CC cord-010092-uftc8inx 7631 14 molecular molecular JJ cord-010092-uftc8inx 7631 15 instruments instrument NNS cord-010092-uftc8inx 7631 16 , , , cord-010092-uftc8inx 7631 17 and and CC cord-010092-uftc8inx 7631 18 the the DT cord-010092-uftc8inx 7631 19 potential potential NN cord-010092-uftc8inx 7631 20 for for IN cord-010092-uftc8inx 7631 21 sample sample NN cord-010092-uftc8inx 7631 22 contamination contamination NN cord-010092-uftc8inx 7631 23 is be VBZ cord-010092-uftc8inx 7631 24 a a DT cord-010092-uftc8inx 7631 25 serious serious JJ cord-010092-uftc8inx 7631 26 risk risk NN cord-010092-uftc8inx 7631 27 to to IN cord-010092-uftc8inx 7631 28 the the DT cord-010092-uftc8inx 7631 29 integrity integrity NN cord-010092-uftc8inx 7631 30 of of IN cord-010092-uftc8inx 7631 31 nucleic nucleic JJ cord-010092-uftc8inx 7631 32 acid acid NN cord-010092-uftc8inx 7631 33 testing testing NN cord-010092-uftc8inx 7631 34 ( ( -LRB- cord-010092-uftc8inx 7631 35 NAT NAT NNP cord-010092-uftc8inx 7631 36 ) ) -RRB- cord-010092-uftc8inx 7631 37 results result NNS cord-010092-uftc8inx 7631 38 . . . cord-010092-uftc8inx 7632 1 The the DT cord-010092-uftc8inx 7632 2 sensitive sensitive JJ cord-010092-uftc8inx 7632 3 limit limit NN cord-010092-uftc8inx 7632 4 of of IN cord-010092-uftc8inx 7632 5 detection detection NN cord-010092-uftc8inx 7632 6 ( ( -LRB- cord-010092-uftc8inx 7632 7 LOD lod NN cord-010092-uftc8inx 7632 8 ) ) -RRB- cord-010092-uftc8inx 7632 9 for for IN cord-010092-uftc8inx 7632 10 HIV HIV NNP cord-010092-uftc8inx 7632 11 and and CC cord-010092-uftc8inx 7632 12 HCV HCV NNP cord-010092-uftc8inx 7632 13 NAT NAT NNP cord-010092-uftc8inx 7632 14 assays assay NNS cord-010092-uftc8inx 7632 15 combined combine VBN cord-010092-uftc8inx 7632 16 with with IN cord-010092-uftc8inx 7632 17 the the DT cord-010092-uftc8inx 7632 18 high high JJ cord-010092-uftc8inx 7632 19 viral viral JJ cord-010092-uftc8inx 7632 20 titers titer NNS cord-010092-uftc8inx 7632 21 encountered encounter VBN cord-010092-uftc8inx 7632 22 in in IN cord-010092-uftc8inx 7632 23 specimens specimen NNS cord-010092-uftc8inx 7632 24 from from IN cord-010092-uftc8inx 7632 25 patients patient NNS cord-010092-uftc8inx 7632 26 with with IN cord-010092-uftc8inx 7632 27 acute acute JJ cord-010092-uftc8inx 7632 28 infections infection NNS cord-010092-uftc8inx 7632 29 presents present VBZ cord-010092-uftc8inx 7632 30 a a DT cord-010092-uftc8inx 7632 31 challenge challenge NN cord-010092-uftc8inx 7632 32 for for IN cord-010092-uftc8inx 7632 33 maintaining maintain VBG cord-010092-uftc8inx 7632 34 the the DT cord-010092-uftc8inx 7632 35 sample sample NN cord-010092-uftc8inx 7632 36 integrity integrity NN cord-010092-uftc8inx 7632 37 of of IN cord-010092-uftc8inx 7632 38 negative negative JJ cord-010092-uftc8inx 7632 39 specimens specimen NNS cord-010092-uftc8inx 7632 40 . . . cord-010092-uftc8inx 7633 1 At at IN cord-010092-uftc8inx 7633 2 additional additional JJ cord-010092-uftc8inx 7633 3 cost cost NN cord-010092-uftc8inx 7633 4 per per IN cord-010092-uftc8inx 7633 5 test test NN cord-010092-uftc8inx 7633 6 , , , cord-010092-uftc8inx 7633 7 this this DT cord-010092-uftc8inx 7633 8 risk risk NN cord-010092-uftc8inx 7633 9 can can MD cord-010092-uftc8inx 7633 10 be be VB cord-010092-uftc8inx 7633 11 reduced reduce VBN cord-010092-uftc8inx 7633 12 with with IN cord-010092-uftc8inx 7633 13 single single JJ cord-010092-uftc8inx 7633 14 - - HYPH cord-010092-uftc8inx 7633 15 use use NN cord-010092-uftc8inx 7633 16 filter filter NN cord-010092-uftc8inx 7633 17 pipette pipette NN cord-010092-uftc8inx 7633 18 tips tip NNS cord-010092-uftc8inx 7633 19 . . . cord-010092-uftc8inx 7634 1 Aims aim VBZ cord-010092-uftc8inx 7634 2 : : : cord-010092-uftc8inx 7634 3 We -PRON- PRP cord-010092-uftc8inx 7634 4 evaluate evaluate VBP cord-010092-uftc8inx 7634 5 the the DT cord-010092-uftc8inx 7634 6 efficacy efficacy NN cord-010092-uftc8inx 7634 7 of of IN cord-010092-uftc8inx 7634 8 applying apply VBG cord-010092-uftc8inx 7634 9 induction induction NN cord-010092-uftc8inx 7634 10 heated heat VBN cord-010092-uftc8inx 7634 11 washes wash NNS cord-010092-uftc8inx 7634 12 to to IN cord-010092-uftc8inx 7634 13 a a DT cord-010092-uftc8inx 7634 14 non non JJ cord-010092-uftc8inx 7634 15 - - JJ cord-010092-uftc8inx 7634 16 disposable disposable JJ cord-010092-uftc8inx 7634 17 pipettor pipettor NN cord-010092-uftc8inx 7634 18 on on IN cord-010092-uftc8inx 7634 19 serology serology NN cord-010092-uftc8inx 7634 20 instruments instrument NNS cord-010092-uftc8inx 7634 21 - - HYPH cord-010092-uftc8inx 7634 22 Alinity Alinity NNP cord-010092-uftc8inx 7634 23 s s NNP cord-010092-uftc8inx 7634 24 , , , cord-010092-uftc8inx 7634 25 Alinity Alinity NNP cord-010092-uftc8inx 7634 26 i i PRP cord-010092-uftc8inx 7634 27 , , , cord-010092-uftc8inx 7634 28 and and CC cord-010092-uftc8inx 7634 29 ARCHITECT ARCHITECT NNP cord-010092-uftc8inx 7634 30 i2000SR i2000SR NNP cord-010092-uftc8inx 7634 31 ( ( -LRB- cord-010092-uftc8inx 7634 32 Abbott Abbott NNP cord-010092-uftc8inx 7634 33 Diagnostics)-to Diagnostics)-to NNP cord-010092-uftc8inx 7634 34 preserve preserve VBP cord-010092-uftc8inx 7634 35 the the DT cord-010092-uftc8inx 7634 36 integrity integrity NN cord-010092-uftc8inx 7634 37 of of IN cord-010092-uftc8inx 7634 38 samples sample NNS cord-010092-uftc8inx 7634 39 transferred transfer VBN cord-010092-uftc8inx 7634 40 to to IN cord-010092-uftc8inx 7634 41 a a DT cord-010092-uftc8inx 7634 42 downstream downstream JJ cord-010092-uftc8inx 7634 43 molecular molecular JJ cord-010092-uftc8inx 7634 44 instrument instrument NN cord-010092-uftc8inx 7634 45 , , , cord-010092-uftc8inx 7634 46 the the DT cord-010092-uftc8inx 7634 47 m2000 m2000 NNP cord-010092-uftc8inx 7634 48 RealTime RealTime NNP cord-010092-uftc8inx 7634 49 ( ( -LRB- cord-010092-uftc8inx 7634 50 Abbott Abbott NNP cord-010092-uftc8inx 7634 51 Molecular Molecular NNP cord-010092-uftc8inx 7634 52 Diagnostics Diagnostics NNPS cord-010092-uftc8inx 7634 53 ) ) -RRB- cord-010092-uftc8inx 7634 54 , , , cord-010092-uftc8inx 7634 55 which which WDT cord-010092-uftc8inx 7634 56 amplifies amplify VBZ cord-010092-uftc8inx 7634 57 viral viral JJ cord-010092-uftc8inx 7634 58 nucleic nucleic JJ cord-010092-uftc8inx 7634 59 acid acid NN cord-010092-uftc8inx 7634 60 targets target NNS cord-010092-uftc8inx 7634 61 exponentially exponentially RB cord-010092-uftc8inx 7634 62 . . . cord-010092-uftc8inx 7635 1 Methods method NNS cord-010092-uftc8inx 7635 2 : : : cord-010092-uftc8inx 7635 3 In in IN cord-010092-uftc8inx 7635 4 this this DT cord-010092-uftc8inx 7635 5 application application NN cord-010092-uftc8inx 7635 6 of of IN cord-010092-uftc8inx 7635 7 induction induction NN cord-010092-uftc8inx 7635 8 heating heating NN cord-010092-uftc8inx 7635 9 , , , cord-010092-uftc8inx 7635 10 the the DT cord-010092-uftc8inx 7635 11 metallic metallic JJ cord-010092-uftc8inx 7635 12 pipettor pipettor NN cord-010092-uftc8inx 7635 13 warms warm VBZ cord-010092-uftc8inx 7635 14 under under IN cord-010092-uftc8inx 7635 15 its -PRON- PRP$ cord-010092-uftc8inx 7635 16 own own JJ cord-010092-uftc8inx 7635 17 resistance resistance NN cord-010092-uftc8inx 7635 18 to to IN cord-010092-uftc8inx 7635 19 coil coil NN cord-010092-uftc8inx 7635 20 - - HYPH cord-010092-uftc8inx 7635 21 induced induce VBN cord-010092-uftc8inx 7635 22 electrical electrical JJ cord-010092-uftc8inx 7635 23 currents current NNS cord-010092-uftc8inx 7635 24 . . . cord-010092-uftc8inx 7636 1 By by IN cord-010092-uftc8inx 7636 2 sweeping sweep VBG cord-010092-uftc8inx 7636 3 the the DT cord-010092-uftc8inx 7636 4 pipettor pipettor NN cord-010092-uftc8inx 7636 5 through through IN cord-010092-uftc8inx 7636 6 an an DT cord-010092-uftc8inx 7636 7 induction induction NN cord-010092-uftc8inx 7636 8 coil coil NN cord-010092-uftc8inx 7636 9 , , , cord-010092-uftc8inx 7636 10 temperatures temperature NNS cord-010092-uftc8inx 7636 11 on on IN cord-010092-uftc8inx 7636 12 the the DT cord-010092-uftc8inx 7636 13 pipettor pipettor NN cord-010092-uftc8inx 7636 14 are be VBP cord-010092-uftc8inx 7636 15 elevated elevate VBN cord-010092-uftc8inx 7636 16 throughout throughout IN cord-010092-uftc8inx 7636 17 its -PRON- PRP$ cord-010092-uftc8inx 7636 18 length length NN cord-010092-uftc8inx 7636 19 . . . cord-010092-uftc8inx 7637 1 Single single JJ cord-010092-uftc8inx 7637 2 donor donor NN cord-010092-uftc8inx 7637 3 high high JJ cord-010092-uftc8inx 7637 4 viral viral JJ cord-010092-uftc8inx 7637 5 titer titer NN cord-010092-uftc8inx 7637 6 HIV HIV NNP cord-010092-uftc8inx 7637 7 genotypes genotype NNS cord-010092-uftc8inx 7637 8 A A NNP cord-010092-uftc8inx 7637 9 ( ( -LRB- cord-010092-uftc8inx 7637 10 5.78 5.78 CD cord-010092-uftc8inx 7637 11 log log NN cord-010092-uftc8inx 7637 12 IU IU NNP cord-010092-uftc8inx 7637 13 / / SYM cord-010092-uftc8inx 7637 14 ml ml NNP cord-010092-uftc8inx 7637 15 ) ) -RRB- cord-010092-uftc8inx 7637 16 , , , cord-010092-uftc8inx 7637 17 B B NNP cord-010092-uftc8inx 7637 18 ( ( -LRB- cord-010092-uftc8inx 7637 19 5.90 5.90 CD cord-010092-uftc8inx 7637 20 log log NN cord-010092-uftc8inx 7637 21 IU IU NNP cord-010092-uftc8inx 7637 22 / / SYM cord-010092-uftc8inx 7637 23 ml ml NNP cord-010092-uftc8inx 7637 24 ) ) -RRB- cord-010092-uftc8inx 7637 25 , , , cord-010092-uftc8inx 7637 26 C C NNP cord-010092-uftc8inx 7637 27 ( ( -LRB- cord-010092-uftc8inx 7638 1 5.62 5.62 CD cord-010092-uftc8inx 7638 2 log log NNP cord-010092-uftc8inx 7638 3 IU IU NNP cord-010092-uftc8inx 7638 4 / / SYM cord-010092-uftc8inx 7638 5 ml ml NNP cord-010092-uftc8inx 7638 6 ) ) -RRB- cord-010092-uftc8inx 7638 7 , , . cord-010092-uftc8inx 7639 1 CRF01 CRF01 NNP cord-010092-uftc8inx 7639 2 ( ( -LRB- cord-010092-uftc8inx 7639 3 5.61 5.61 CD cord-010092-uftc8inx 7639 4 log log NN cord-010092-uftc8inx 7639 5 IU IU NNP cord-010092-uftc8inx 7639 6 / / SYM cord-010092-uftc8inx 7639 7 ml ml NNP cord-010092-uftc8inx 7639 8 ) ) -RRB- cord-010092-uftc8inx 7639 9 , , . cord-010092-uftc8inx 7640 1 CRF02 CRF02 NNP cord-010092-uftc8inx 7640 2 ( ( -LRB- cord-010092-uftc8inx 7640 3 6.19 6.19 CD cord-010092-uftc8inx 7640 4 log log NN cord-010092-uftc8inx 7640 5 IU IU NNP cord-010092-uftc8inx 7640 6 / / SYM cord-010092-uftc8inx 7640 7 ml ml NNP cord-010092-uftc8inx 7640 8 ) ) -RRB- cord-010092-uftc8inx 7640 9 , , , cord-010092-uftc8inx 7640 10 and and CC cord-010092-uftc8inx 7640 11 URF URF NNP cord-010092-uftc8inx 7640 12 ( ( -LRB- cord-010092-uftc8inx 7640 13 6.33 6.33 CD cord-010092-uftc8inx 7640 14 log log NN cord-010092-uftc8inx 7640 15 IU IU NNP cord-010092-uftc8inx 7640 16 / / SYM cord-010092-uftc8inx 7640 17 ml ml NNP cord-010092-uftc8inx 7640 18 ) ) -RRB- cord-010092-uftc8inx 7640 19 , , , cord-010092-uftc8inx 7640 20 as as RB cord-010092-uftc8inx 7640 21 well well RB cord-010092-uftc8inx 7640 22 as as IN cord-010092-uftc8inx 7640 23 single single JJ cord-010092-uftc8inx 7640 24 donor donor NN cord-010092-uftc8inx 7640 25 high high JJ cord-010092-uftc8inx 7640 26 viral viral JJ cord-010092-uftc8inx 7640 27 titer titer NN cord-010092-uftc8inx 7640 28 HCV HCV NNP cord-010092-uftc8inx 7640 29 genotypes genotype NNS cord-010092-uftc8inx 7640 30 1a 1a CD cord-010092-uftc8inx 7640 31 ( ( -LRB- cord-010092-uftc8inx 7640 32 6.84 6.84 CD cord-010092-uftc8inx 7640 33 log log NN cord-010092-uftc8inx 7640 34 IU IU NNP cord-010092-uftc8inx 7640 35 / / SYM cord-010092-uftc8inx 7640 36 ml ml NNP cord-010092-uftc8inx 7640 37 ) ) -RRB- cord-010092-uftc8inx 7640 38 , , , cord-010092-uftc8inx 7640 39 1b 1b CD cord-010092-uftc8inx 7640 40 ( ( -LRB- cord-010092-uftc8inx 7640 41 6.73 6.73 CD cord-010092-uftc8inx 7640 42 log log NN cord-010092-uftc8inx 7640 43 IU IU NNP cord-010092-uftc8inx 7640 44 / / SYM cord-010092-uftc8inx 7640 45 ml ml NNP cord-010092-uftc8inx 7640 46 ) ) -RRB- cord-010092-uftc8inx 7640 47 , , , cord-010092-uftc8inx 7640 48 3a 3a NNP cord-010092-uftc8inx 7640 49 ( ( -LRB- cord-010092-uftc8inx 7640 50 6.64 6.64 CD cord-010092-uftc8inx 7640 51 log log NN cord-010092-uftc8inx 7640 52 IU IU NNP cord-010092-uftc8inx 7640 53 / / SYM cord-010092-uftc8inx 7640 54 ml ml NNP cord-010092-uftc8inx 7640 55 ) ) -RRB- cord-010092-uftc8inx 7640 56 , , , cord-010092-uftc8inx 7640 57 2 2 CD cord-010092-uftc8inx 7640 58 ( ( -LRB- cord-010092-uftc8inx 7640 59 6.10 6.10 CD cord-010092-uftc8inx 7640 60 log log NN cord-010092-uftc8inx 7640 61 IU IU NNP cord-010092-uftc8inx 7640 62 / / SYM cord-010092-uftc8inx 7640 63 ml ml NNP cord-010092-uftc8inx 7640 64 ) ) -RRB- cord-010092-uftc8inx 7640 65 , , , cord-010092-uftc8inx 7640 66 2q 2q CD cord-010092-uftc8inx 7640 67 ( ( -LRB- cord-010092-uftc8inx 7640 68 6.65 6.65 CD cord-010092-uftc8inx 7640 69 log log NN cord-010092-uftc8inx 7640 70 IU/ iu/ PRP$ cord-010092-uftc8inx 7640 71 ml ml NN cord-010092-uftc8inx 7640 72 ) ) -RRB- cord-010092-uftc8inx 7640 73 , , , cord-010092-uftc8inx 7640 74 and and CC cord-010092-uftc8inx 7640 75 4 4 CD cord-010092-uftc8inx 7640 76 t t NN cord-010092-uftc8inx 7640 77 ( ( -LRB- cord-010092-uftc8inx 7640 78 6.07 6.07 CD cord-010092-uftc8inx 7640 79 log log NN cord-010092-uftc8inx 7640 80 IU IU NNP cord-010092-uftc8inx 7640 81 / / SYM cord-010092-uftc8inx 7640 82 ml ml NN cord-010092-uftc8inx 7640 83 ) ) -RRB- cord-010092-uftc8inx 7640 84 were be VBD cord-010092-uftc8inx 7640 85 used use VBN cord-010092-uftc8inx 7640 86 as as IN cord-010092-uftc8inx 7640 87 potential potential JJ cord-010092-uftc8inx 7640 88 sources source NNS cord-010092-uftc8inx 7640 89 of of IN cord-010092-uftc8inx 7640 90 contamination contamination NN cord-010092-uftc8inx 7640 91 ; ; : cord-010092-uftc8inx 7640 92 these these DT cord-010092-uftc8inx 7640 93 genotypes genotype NNS cord-010092-uftc8inx 7640 94 account account VBP cord-010092-uftc8inx 7640 95 for for IN cord-010092-uftc8inx 7640 96 the the DT cord-010092-uftc8inx 7640 97 majority majority NN cord-010092-uftc8inx 7640 98 of of IN cord-010092-uftc8inx 7640 99 HIV HIV NNP cord-010092-uftc8inx 7640 100 and and CC cord-010092-uftc8inx 7640 101 HCV HCV NNP cord-010092-uftc8inx 7640 102 infections infection NNS cord-010092-uftc8inx 7640 103 worldwide worldwide RB cord-010092-uftc8inx 7640 104 . . . cord-010092-uftc8inx 7641 1 On on IN cord-010092-uftc8inx 7641 2 serology serology NN cord-010092-uftc8inx 7641 3 instruments instrument NNS cord-010092-uftc8inx 7641 4 , , , cord-010092-uftc8inx 7641 5 one one CD cord-010092-uftc8inx 7641 6 high high JJ cord-010092-uftc8inx 7641 7 viral viral JJ cord-010092-uftc8inx 7641 8 titer titer NN cord-010092-uftc8inx 7641 9 HIV HIV NNP cord-010092-uftc8inx 7641 10 or or CC cord-010092-uftc8inx 7641 11 HCV HCV NNP cord-010092-uftc8inx 7641 12 specimen specimen NN cord-010092-uftc8inx 7641 13 and and CC cord-010092-uftc8inx 7641 14 three three CD cord-010092-uftc8inx 7641 15 consecutive consecutive JJ cord-010092-uftc8inx 7641 16 susceptible susceptible JJ cord-010092-uftc8inx 7641 17 negative negative JJ cord-010092-uftc8inx 7641 18 samples sample NNS cord-010092-uftc8inx 7641 19 ( ( -LRB- cord-010092-uftc8inx 7641 20 HIV HIV NNP cord-010092-uftc8inx 7641 21 / / SYM cord-010092-uftc8inx 7641 22 HCV HCV NNP cord-010092-uftc8inx 7641 23 RNA RNA NNP cord-010092-uftc8inx 7641 24 negative negative JJ cord-010092-uftc8inx 7641 25 human human JJ cord-010092-uftc8inx 7641 26 plasma plasma NN cord-010092-uftc8inx 7641 27 , , , cord-010092-uftc8inx 7641 28 Abbott Abbott NNP cord-010092-uftc8inx 7641 29 Molecular Molecular NNP cord-010092-uftc8inx 7641 30 Diagnostics Diagnostics NNPS cord-010092-uftc8inx 7641 31 ) ) -RRB- cord-010092-uftc8inx 7641 32 were be VBD cord-010092-uftc8inx 7641 33 tested test VBN cord-010092-uftc8inx 7641 34 on on IN cord-010092-uftc8inx 7641 35 an an DT cord-010092-uftc8inx 7641 36 HIV HIV NNP cord-010092-uftc8inx 7641 37 Ag Ag NNP cord-010092-uftc8inx 7641 38 / / SYM cord-010092-uftc8inx 7641 39 Ab Ab NNP cord-010092-uftc8inx 7641 40 Combo Combo NNP cord-010092-uftc8inx 7641 41 or or CC cord-010092-uftc8inx 7641 42 anti anti JJ cord-010092-uftc8inx 7641 43 - - JJ cord-010092-uftc8inx 7641 44 HCV hcv JJ cord-010092-uftc8inx 7641 45 immunoassay immunoassay NN cord-010092-uftc8inx 7641 46 ( ( -LRB- cord-010092-uftc8inx 7641 47 Abbott Abbott NNP cord-010092-uftc8inx 7641 48 Diagnostics Diagnostics NNP cord-010092-uftc8inx 7641 49 ) ) -RRB- cord-010092-uftc8inx 7641 50 , , , cord-010092-uftc8inx 7641 51 and and CC cord-010092-uftc8inx 7641 52 this this DT cord-010092-uftc8inx 7641 53 schema schema NN cord-010092-uftc8inx 7641 54 was be VBD cord-010092-uftc8inx 7641 55 repeated repeat VBN cord-010092-uftc8inx 7641 56 four four CD cord-010092-uftc8inx 7641 57 times time NNS cord-010092-uftc8inx 7641 58 per per IN cord-010092-uftc8inx 7641 59 positive positive JJ cord-010092-uftc8inx 7641 60 specimen specimen NN cord-010092-uftc8inx 7641 61 . . . cord-010092-uftc8inx 7642 1 Induction induction NN cord-010092-uftc8inx 7642 2 heated heated JJ cord-010092-uftc8inx 7642 3 washes wash NNS cord-010092-uftc8inx 7642 4 occurred occur VBD cord-010092-uftc8inx 7642 5 between between IN cord-010092-uftc8inx 7642 6 all all DT cord-010092-uftc8inx 7642 7 samples sample NNS cord-010092-uftc8inx 7642 8 processed process VBN cord-010092-uftc8inx 7642 9 on on IN cord-010092-uftc8inx 7642 10 the the DT cord-010092-uftc8inx 7642 11 serology serology NN cord-010092-uftc8inx 7642 12 instruments instrument NNS cord-010092-uftc8inx 7642 13 . . . cord-010092-uftc8inx 7643 1 The the DT cord-010092-uftc8inx 7643 2 first first JJ cord-010092-uftc8inx 7643 3 susceptible susceptible JJ cord-010092-uftc8inx 7643 4 negative negative JJ cord-010092-uftc8inx 7643 5 from from IN cord-010092-uftc8inx 7643 6 each each DT cord-010092-uftc8inx 7643 7 testing testing NN cord-010092-uftc8inx 7643 8 block block NN cord-010092-uftc8inx 7643 9 , , , cord-010092-uftc8inx 7643 10 with with IN cord-010092-uftc8inx 7643 11 approximately approximately RB cord-010092-uftc8inx 7643 12 1 1 CD cord-010092-uftc8inx 7643 13 ml ml NNS cord-010092-uftc8inx 7643 14 of of IN cord-010092-uftc8inx 7643 15 residual residual JJ cord-010092-uftc8inx 7643 16 sample sample NN cord-010092-uftc8inx 7643 17 volume volume NN cord-010092-uftc8inx 7643 18 , , , cord-010092-uftc8inx 7643 19 was be VBD cord-010092-uftc8inx 7643 20 then then RB cord-010092-uftc8inx 7643 21 tested test VBN cord-010092-uftc8inx 7643 22 using use VBG cord-010092-uftc8inx 7643 23 the the DT cord-010092-uftc8inx 7643 24 0.6 0.6 CD cord-010092-uftc8inx 7643 25 ml ml NN cord-010092-uftc8inx 7643 26 Abbott Abbott NNP cord-010092-uftc8inx 7643 27 RealTime RealTime NNP cord-010092-uftc8inx 7643 28 HIV HIV NNP cord-010092-uftc8inx 7643 29 assay assay NN cord-010092-uftc8inx 7643 30 ( ( -LRB- cord-010092-uftc8inx 7643 31 LOD lod NN cord-010092-uftc8inx 7643 32 40 40 CD cord-010092-uftc8inx 7643 33 copies copy NNS cord-010092-uftc8inx 7643 34 / / SYM cord-010092-uftc8inx 7643 35 ml ml NN cord-010092-uftc8inx 7643 36 ) ) -RRB- cord-010092-uftc8inx 7643 37 or or CC cord-010092-uftc8inx 7644 1 0.5 0.5 CD cord-010092-uftc8inx 7644 2 ml ml XX cord-010092-uftc8inx 7644 3 Abbott Abbott NNP cord-010092-uftc8inx 7644 4 RealTime RealTime NNP cord-010092-uftc8inx 7644 5 HCV HCV NNP cord-010092-uftc8inx 7644 6 assay assay NN cord-010092-uftc8inx 7644 7 ( ( -LRB- cord-010092-uftc8inx 7644 8 LOD LOD NNP cord-010092-uftc8inx 7644 9 12 12 CD cord-010092-uftc8inx 7644 10 IU IU NNP cord-010092-uftc8inx 7644 11 / / SYM cord-010092-uftc8inx 7644 12 ml ml NN cord-010092-uftc8inx 7644 13 ) ) -RRB- cord-010092-uftc8inx 7644 14 and and CC cord-010092-uftc8inx 7644 15 an an DT cord-010092-uftc8inx 7644 16 HCV HCV NNP cord-010092-uftc8inx 7644 17 Ag Ag NNP cord-010092-uftc8inx 7644 18 immunoassay immunoassay NN cord-010092-uftc8inx 7644 19 ( ( -LRB- cord-010092-uftc8inx 7644 20 LOD LOD NNP cord-010092-uftc8inx 7644 21 1.24 1.24 CD cord-010092-uftc8inx 7644 22 fmol fmol NNP cord-010092-uftc8inx 7644 23 / / SYM cord-010092-uftc8inx 7644 24 l l NN cord-010092-uftc8inx 7644 25 ; ; : cord-010092-uftc8inx 7644 26 Abbott Abbott NNP cord-010092-uftc8inx 7644 27 Diagnostics Diagnostics NNP cord-010092-uftc8inx 7644 28 ) ) -RRB- cord-010092-uftc8inx 7644 29 . . . cord-010092-uftc8inx 7645 1 Study study NN cord-010092-uftc8inx 7645 2 acceptance acceptance NN cord-010092-uftc8inx 7645 3 criteria criterion NNS cord-010092-uftc8inx 7645 4 required require VBD cord-010092-uftc8inx 7645 5 that that IN cord-010092-uftc8inx 7645 6 any any DT cord-010092-uftc8inx 7645 7 susceptible susceptible JJ cord-010092-uftc8inx 7645 8 negative negative JJ cord-010092-uftc8inx 7645 9 sample sample NN cord-010092-uftc8inx 7645 10 had have VBD cord-010092-uftc8inx 7645 11 no no DT cord-010092-uftc8inx 7645 12 detectable detectable JJ cord-010092-uftc8inx 7645 13 level level NN cord-010092-uftc8inx 7645 14 of of IN cord-010092-uftc8inx 7645 15 HIV HIV NNP cord-010092-uftc8inx 7645 16 or or CC cord-010092-uftc8inx 7645 17 HCV HCV NNP cord-010092-uftc8inx 7645 18 RNA RNA NNP cord-010092-uftc8inx 7645 19 . . . cord-010092-uftc8inx 7646 1 Results result NNS cord-010092-uftc8inx 7646 2 : : : cord-010092-uftc8inx 7647 1 All all DT cord-010092-uftc8inx 7647 2 first first RB cord-010092-uftc8inx 7647 3 susceptible susceptible JJ cord-010092-uftc8inx 7647 4 negative negative JJ cord-010092-uftc8inx 7647 5 samples sample NNS cord-010092-uftc8inx 7647 6 ( ( -LRB- cord-010092-uftc8inx 7647 7 n n NN cord-010092-uftc8inx 7647 8 = = SYM cord-010092-uftc8inx 7647 9 24 24 CD cord-010092-uftc8inx 7647 10 per per IN cord-010092-uftc8inx 7647 11 platform platform NN cord-010092-uftc8inx 7647 12 per per IN cord-010092-uftc8inx 7647 13 virus virus NN cord-010092-uftc8inx 7647 14 schema schema NN cord-010092-uftc8inx 7647 15 ) ) -RRB- cord-010092-uftc8inx 7647 16 run run VBN cord-010092-uftc8inx 7647 17 on on IN cord-010092-uftc8inx 7647 18 Alinity Alinity NNP cord-010092-uftc8inx 7647 19 s s NNP cord-010092-uftc8inx 7647 20 , , , cord-010092-uftc8inx 7647 21 Alinity Alinity NNP cord-010092-uftc8inx 7647 22 i i PRP cord-010092-uftc8inx 7647 23 , , , cord-010092-uftc8inx 7647 24 and and CC cord-010092-uftc8inx 7647 25 ARCHITECT ARCHITECT NNP cord-010092-uftc8inx 7647 26 i2000SR i2000SR NNP cord-010092-uftc8inx 7647 27 using use VBG cord-010092-uftc8inx 7647 28 induction induction NN cord-010092-uftc8inx 7647 29 heated heat VBN cord-010092-uftc8inx 7647 30 washes wash NNS cord-010092-uftc8inx 7647 31 after after IN cord-010092-uftc8inx 7647 32 a a DT cord-010092-uftc8inx 7647 33 high high JJ cord-010092-uftc8inx 7647 34 viral viral JJ cord-010092-uftc8inx 7647 35 titer titer NN cord-010092-uftc8inx 7647 36 HIV HIV NNP cord-010092-uftc8inx 7647 37 specimen specimen NN cord-010092-uftc8inx 7647 38 or or CC cord-010092-uftc8inx 7647 39 HCV HCV NNP cord-010092-uftc8inx 7647 40 specimen specimen NN cord-010092-uftc8inx 7647 41 were be VBD cord-010092-uftc8inx 7647 42 HIV HIV NNP cord-010092-uftc8inx 7647 43 Ag Ag NNP cord-010092-uftc8inx 7647 44 / / SYM cord-010092-uftc8inx 7647 45 Ab Ab NNP cord-010092-uftc8inx 7647 46 Combo Combo NNP cord-010092-uftc8inx 7647 47 nonreactive nonreactive JJ cord-010092-uftc8inx 7647 48 ( ( -LRB- cord-010092-uftc8inx 7647 49 < < XX cord-010092-uftc8inx 7647 50 0.20 0.20 CD cord-010092-uftc8inx 7647 51 S S NNP cord-010092-uftc8inx 7647 52 / / SYM cord-010092-uftc8inx 7647 53 CO CO NNP cord-010092-uftc8inx 7647 54 ) ) -RRB- cord-010092-uftc8inx 7647 55 and and CC cord-010092-uftc8inx 7647 56 reported report VBD cord-010092-uftc8inx 7647 57 no no DT cord-010092-uftc8inx 7647 58 detectable detectable JJ cord-010092-uftc8inx 7647 59 level level NN cord-010092-uftc8inx 7647 60 of of IN cord-010092-uftc8inx 7647 61 the the DT cord-010092-uftc8inx 7647 62 HIV HIV NNP cord-010092-uftc8inx 7647 63 RNA RNA NNP cord-010092-uftc8inx 7647 64 target target NN cord-010092-uftc8inx 7647 65 , , , cord-010092-uftc8inx 7647 66 or or CC cord-010092-uftc8inx 7647 67 were be VBD cord-010092-uftc8inx 7647 68 anti anti JJ cord-010092-uftc8inx 7647 69 - - JJ cord-010092-uftc8inx 7647 70 HCV hcv JJ cord-010092-uftc8inx 7647 71 nonreactive nonreactive NN cord-010092-uftc8inx 7647 72 ( ( -LRB- cord-010092-uftc8inx 7647 73 < < XX cord-010092-uftc8inx 7647 74 0.20 0.20 CD cord-010092-uftc8inx 7647 75 S S NNP cord-010092-uftc8inx 7647 76 / / SYM cord-010092-uftc8inx 7647 77 CO CO NNP cord-010092-uftc8inx 7647 78 ) ) -RRB- cord-010092-uftc8inx 7647 79 and and CC cord-010092-uftc8inx 7647 80 reported report VBD cord-010092-uftc8inx 7647 81 no no DT cord-010092-uftc8inx 7647 82 detectable detectable JJ cord-010092-uftc8inx 7647 83 level level NN cord-010092-uftc8inx 7647 84 of of IN cord-010092-uftc8inx 7647 85 the the DT cord-010092-uftc8inx 7647 86 HCV HCV NNP cord-010092-uftc8inx 7647 87 RNA RNA NNP cord-010092-uftc8inx 7647 88 or or CC cord-010092-uftc8inx 7647 89 core core NN cord-010092-uftc8inx 7647 90 antigen antigen NN cord-010092-uftc8inx 7647 91 targets target NNS cord-010092-uftc8inx 7647 92 . . . cord-010092-uftc8inx 7648 1 Summary Summary NNP cord-010092-uftc8inx 7648 2 / / SYM cord-010092-uftc8inx 7648 3 Conclusions conclusion NNS cord-010092-uftc8inx 7648 4 : : : cord-010092-uftc8inx 7648 5 While while IN cord-010092-uftc8inx 7648 6 precautions precaution NNS cord-010092-uftc8inx 7648 7 should should MD cord-010092-uftc8inx 7648 8 continue continue VB cord-010092-uftc8inx 7648 9 to to TO cord-010092-uftc8inx 7648 10 be be VB cord-010092-uftc8inx 7648 11 taken take VBN cord-010092-uftc8inx 7648 12 for for IN cord-010092-uftc8inx 7648 13 samples sample NNS cord-010092-uftc8inx 7648 14 run run VBN cord-010092-uftc8inx 7648 15 on on IN cord-010092-uftc8inx 7648 16 molecular molecular JJ cord-010092-uftc8inx 7648 17 instruments instrument NNS cord-010092-uftc8inx 7648 18 , , , cord-010092-uftc8inx 7648 19 the the DT cord-010092-uftc8inx 7648 20 integrity integrity NN cord-010092-uftc8inx 7648 21 of of IN cord-010092-uftc8inx 7648 22 samples sample NNS cord-010092-uftc8inx 7648 23 originally originally RB cord-010092-uftc8inx 7648 24 tested test VBN cord-010092-uftc8inx 7648 25 on on IN cord-010092-uftc8inx 7648 26 the the DT cord-010092-uftc8inx 7648 27 Alinity Alinity NNP cord-010092-uftc8inx 7648 28 s s NNP cord-010092-uftc8inx 7648 29 , , , cord-010092-uftc8inx 7648 30 Alinity Alinity NNP cord-010092-uftc8inx 7648 31 i i PRP cord-010092-uftc8inx 7648 32 , , , cord-010092-uftc8inx 7648 33 and and CC cord-010092-uftc8inx 7648 34 ARCHITECT ARCHITECT NNP cord-010092-uftc8inx 7648 35 i2000SR i2000SR NNP cord-010092-uftc8inx 7648 36 was be VBD cord-010092-uftc8inx 7648 37 preserved preserve VBN cord-010092-uftc8inx 7648 38 for for IN cord-010092-uftc8inx 7648 39 downstream downstream JJ cord-010092-uftc8inx 7648 40 molecular molecular JJ cord-010092-uftc8inx 7648 41 testing testing NN cord-010092-uftc8inx 7648 42 through through IN cord-010092-uftc8inx 7648 43 the the DT cord-010092-uftc8inx 7648 44 use use NN cord-010092-uftc8inx 7648 45 of of IN cord-010092-uftc8inx 7648 46 induction induction NN cord-010092-uftc8inx 7648 47 heated heat VBN cord-010092-uftc8inx 7648 48 washes wash NNS cord-010092-uftc8inx 7648 49 . . . cord-010092-uftc8inx 7649 1 Aims aim VBZ cord-010092-uftc8inx 7649 2 : : : cord-010092-uftc8inx 7650 1 Increasing increase VBG cord-010092-uftc8inx 7650 2 the the DT cord-010092-uftc8inx 7650 3 safety safety NN cord-010092-uftc8inx 7650 4 of of IN cord-010092-uftc8inx 7650 5 blood blood NN cord-010092-uftc8inx 7650 6 and and CC cord-010092-uftc8inx 7650 7 blood blood NN cord-010092-uftc8inx 7650 8 products product NNS cord-010092-uftc8inx 7650 9 -Motivating -Motivating . cord-010092-uftc8inx 7651 1 the the DT cord-010092-uftc8inx 7651 2 blood blood NN cord-010092-uftc8inx 7651 3 donors donor NNS cord-010092-uftc8inx 7651 4 to to TO cord-010092-uftc8inx 7651 5 be be VB cord-010092-uftc8inx 7651 6 regular regular JJ cord-010092-uftc8inx 7651 7 donors donor NNS cord-010092-uftc8inx 7651 8 Methods method NNS cord-010092-uftc8inx 7651 9 : : : cord-010092-uftc8inx 7651 10 National national JJ cord-010092-uftc8inx 7651 11 reporting reporting NN cord-010092-uftc8inx 7651 12 system system NN cord-010092-uftc8inx 7651 13 showed show VBD cord-010092-uftc8inx 7651 14 the the DT cord-010092-uftc8inx 7651 15 high high JJ cord-010092-uftc8inx 7651 16 prevalence prevalence NN cord-010092-uftc8inx 7651 17 of of IN cord-010092-uftc8inx 7651 18 TTIs tti NNS cord-010092-uftc8inx 7651 19 among among IN cord-010092-uftc8inx 7651 20 first first JJ cord-010092-uftc8inx 7651 21 blood blood NN cord-010092-uftc8inx 7651 22 donors donor NNS cord-010092-uftc8inx 7651 23 in in IN cord-010092-uftc8inx 7651 24 compares compare NNS cord-010092-uftc8inx 7651 25 with with IN cord-010092-uftc8inx 7651 26 the the DT cord-010092-uftc8inx 7651 27 regular regular JJ cord-010092-uftc8inx 7651 28 donors donor NNS cord-010092-uftc8inx 7651 29 . . . cord-010092-uftc8inx 7652 1 In in IN cord-010092-uftc8inx 7652 2 2015 2015 CD cord-010092-uftc8inx 7652 3 per per IN cord-010092-uftc8inx 7652 4 2.083.914 2.083.914 CD cord-010092-uftc8inx 7652 5 donations donation NNS cord-010092-uftc8inx 7652 6 , , , cord-010092-uftc8inx 7652 7 54 54 CD cord-010092-uftc8inx 7652 8 % % NN cord-010092-uftc8inx 7652 9 % % NN cord-010092-uftc8inx 7652 10 of of IN cord-010092-uftc8inx 7652 11 confirmed confirm VBN cord-010092-uftc8inx 7652 12 positive positive JJ cord-010092-uftc8inx 7652 13 HIV HIV NNP cord-010092-uftc8inx 7652 14 , , , cord-010092-uftc8inx 7652 15 87 87 CD cord-010092-uftc8inx 7652 16 % % NN cord-010092-uftc8inx 7652 17 of of IN cord-010092-uftc8inx 7652 18 HCV HCV NNP cord-010092-uftc8inx 7652 19 , , , cord-010092-uftc8inx 7652 20 and and CC cord-010092-uftc8inx 7652 21 93 93 CD cord-010092-uftc8inx 7652 22 % % NN cord-010092-uftc8inx 7652 23 of of IN cord-010092-uftc8inx 7652 24 HBV HBV NNP cord-010092-uftc8inx 7652 25 cases case NNS cord-010092-uftc8inx 7652 26 has have VBZ cord-010092-uftc8inx 7652 27 been be VBN cord-010092-uftc8inx 7652 28 reported report VBN cord-010092-uftc8inx 7652 29 among among IN cord-010092-uftc8inx 7652 30 first first JJ cord-010092-uftc8inx 7652 31 blood blood NN cord-010092-uftc8inx 7652 32 donors donor NNS cord-010092-uftc8inx 7652 33 . . . cord-010092-uftc8inx 7653 1 In in IN cord-010092-uftc8inx 7653 2 the the DT cord-010092-uftc8inx 7653 3 end end NN cord-010092-uftc8inx 7653 4 of of IN cord-010092-uftc8inx 7653 5 2015 2015 CD cord-010092-uftc8inx 7653 6 a a DT cord-010092-uftc8inx 7653 7 national national JJ cord-010092-uftc8inx 7653 8 program program NN cord-010092-uftc8inx 7653 9 named name VBN cord-010092-uftc8inx 7653 10 " " `` cord-010092-uftc8inx 7653 11 Pre Pre NNP cord-010092-uftc8inx 7653 12 - - JJ cord-010092-uftc8inx 7653 13 Donation donation NN cord-010092-uftc8inx 7653 14 Screening Screening NNP cord-010092-uftc8inx 7653 15 Tests Tests NNPS cord-010092-uftc8inx 7653 16 " " '' cord-010092-uftc8inx 7653 17 has have VBZ cord-010092-uftc8inx 7653 18 been be VBN cord-010092-uftc8inx 7653 19 developed develop VBN cord-010092-uftc8inx 7653 20 and and CC cord-010092-uftc8inx 7653 21 has have VBZ cord-010092-uftc8inx 7653 22 been be VBN cord-010092-uftc8inx 7653 23 implemented implement VBN cord-010092-uftc8inx 7653 24 in in IN cord-010092-uftc8inx 7653 25 high high JJ cord-010092-uftc8inx 7653 26 prevalence prevalence NN cord-010092-uftc8inx 7653 27 provinces province NNS cord-010092-uftc8inx 7653 28 in in IN cord-010092-uftc8inx 7653 29 whole whole JJ cord-010092-uftc8inx 7653 30 country country NN cord-010092-uftc8inx 7653 31 . . . cord-010092-uftc8inx 7654 1 Based base VBN cord-010092-uftc8inx 7654 2 on on IN cord-010092-uftc8inx 7654 3 this this DT cord-010092-uftc8inx 7654 4 program program NN cord-010092-uftc8inx 7654 5 , , , cord-010092-uftc8inx 7654 6 all all DT cord-010092-uftc8inx 7654 7 first first JJ cord-010092-uftc8inx 7654 8 blood blood NN cord-010092-uftc8inx 7654 9 donors donor NNS cord-010092-uftc8inx 7654 10 who who WP cord-010092-uftc8inx 7654 11 accept accept VBP cord-010092-uftc8inx 7654 12 in in IN cord-010092-uftc8inx 7654 13 donation donation NN cord-010092-uftc8inx 7654 14 sites site NNS cord-010092-uftc8inx 7654 15 , , , cord-010092-uftc8inx 7654 16 if if IN cord-010092-uftc8inx 7654 17 after after IN cord-010092-uftc8inx 7654 18 donor donor NN cord-010092-uftc8inx 7654 19 selection selection NN cord-010092-uftc8inx 7654 20 process process NN cord-010092-uftc8inx 7654 21 are be VBP cord-010092-uftc8inx 7654 22 eligible eligible JJ cord-010092-uftc8inx 7654 23 to to TO cord-010092-uftc8inx 7654 24 donate donate VB cord-010092-uftc8inx 7654 25 blood blood NN cord-010092-uftc8inx 7654 26 , , , cord-010092-uftc8inx 7654 27 they -PRON- PRP cord-010092-uftc8inx 7654 28 refer refer VBP cord-010092-uftc8inx 7654 29 to to TO cord-010092-uftc8inx 7654 30 give give VB cord-010092-uftc8inx 7654 31 just just RB cord-010092-uftc8inx 7654 32 a a DT cord-010092-uftc8inx 7654 33 blood blood NN cord-010092-uftc8inx 7654 34 sample sample NN cord-010092-uftc8inx 7654 35 for for IN cord-010092-uftc8inx 7654 36 screening screen VBG cord-010092-uftc8inx 7654 37 TTIs tti NNS cord-010092-uftc8inx 7654 38 tests test NNS cord-010092-uftc8inx 7654 39 . . . cord-010092-uftc8inx 7655 1 After after IN cord-010092-uftc8inx 7655 2 3 3 CD cord-010092-uftc8inx 7655 3 months month NNS cord-010092-uftc8inx 7655 4 , , , cord-010092-uftc8inx 7655 5 the the DT cord-010092-uftc8inx 7655 6 invitation invitation NN cord-010092-uftc8inx 7655 7 letters letter NNS cord-010092-uftc8inx 7655 8 and and CC cord-010092-uftc8inx 7655 9 SMSs sms NNS cord-010092-uftc8inx 7655 10 send send VBP cord-010092-uftc8inx 7655 11 to to IN cord-010092-uftc8inx 7655 12 the the DT cord-010092-uftc8inx 7655 13 donors donor NNS cord-010092-uftc8inx 7655 14 who who WP cord-010092-uftc8inx 7655 15 have have VBP cord-010092-uftc8inx 7655 16 negative negative JJ cord-010092-uftc8inx 7655 17 results result NNS cord-010092-uftc8inx 7655 18 for for IN cord-010092-uftc8inx 7655 19 all all DT cord-010092-uftc8inx 7655 20 screening screen VBG cord-010092-uftc8inx 7655 21 TTIs tti NNS cord-010092-uftc8inx 7655 22 tests test NNS cord-010092-uftc8inx 7655 23 , , , cord-010092-uftc8inx 7655 24 and and CC cord-010092-uftc8inx 7655 25 they -PRON- PRP cord-010092-uftc8inx 7655 26 can can MD cord-010092-uftc8inx 7655 27 be be VB cord-010092-uftc8inx 7655 28 eligible eligible JJ cord-010092-uftc8inx 7655 29 to to TO cord-010092-uftc8inx 7655 30 donate donate VB cord-010092-uftc8inx 7655 31 blood blood NN cord-010092-uftc8inx 7655 32 after after IN cord-010092-uftc8inx 7655 33 another another DT cord-010092-uftc8inx 7655 34 donor donor NN cord-010092-uftc8inx 7655 35 selection selection NN cord-010092-uftc8inx 7655 36 process process NN cord-010092-uftc8inx 7655 37 . . . cord-010092-uftc8inx 7656 1 In in IN cord-010092-uftc8inx 7656 2 2015 2015 CD cord-010092-uftc8inx 7656 3 , , , cord-010092-uftc8inx 7656 4 about about RB cord-010092-uftc8inx 7656 5 0.156 0.156 CD cord-010092-uftc8inx 7656 6 % % NN cord-010092-uftc8inx 7656 7 of of IN cord-010092-uftc8inx 7656 8 all all DT cord-010092-uftc8inx 7656 9 donations donation NNS cord-010092-uftc8inx 7656 10 have have VBP cord-010092-uftc8inx 7656 11 been be VBN cord-010092-uftc8inx 7656 12 rejected reject VBN cord-010092-uftc8inx 7656 13 because because IN cord-010092-uftc8inx 7656 14 of of IN cord-010092-uftc8inx 7656 15 at at RB cord-010092-uftc8inx 7656 16 least least RBS cord-010092-uftc8inx 7656 17 one one CD cord-010092-uftc8inx 7656 18 of of IN cord-010092-uftc8inx 7656 19 HIV HIV NNP cord-010092-uftc8inx 7656 20 , , , cord-010092-uftc8inx 7656 21 HCV HCV NNP cord-010092-uftc8inx 7656 22 , , , cord-010092-uftc8inx 7656 23 or or CC cord-010092-uftc8inx 7656 24 HBV HBV NNP cord-010092-uftc8inx 7656 25 confirmed confirm VBD cord-010092-uftc8inx 7656 26 positive positive JJ cord-010092-uftc8inx 7656 27 results result NNS cord-010092-uftc8inx 7656 28 , , , cord-010092-uftc8inx 7656 29 while while IN cord-010092-uftc8inx 7656 30 this this DT cord-010092-uftc8inx 7656 31 reject reject NN cord-010092-uftc8inx 7656 32 rate rate NN cord-010092-uftc8inx 7656 33 in in IN cord-010092-uftc8inx 7656 34 2017 2017 CD cord-010092-uftc8inx 7656 35 was be VBD cord-010092-uftc8inx 7656 36 0.082 0.082 CD cord-010092-uftc8inx 7656 37 % % NN cord-010092-uftc8inx 7656 38 , , , cord-010092-uftc8inx 7656 39 which which WDT cord-010092-uftc8inx 7656 40 shows show VBZ cord-010092-uftc8inx 7656 41 a a DT cord-010092-uftc8inx 7656 42 significant significant JJ cord-010092-uftc8inx 7656 43 decreasing decrease VBG cord-010092-uftc8inx 7656 44 the the DT cord-010092-uftc8inx 7656 45 TTIs tti NNS cord-010092-uftc8inx 7656 46 prevalence prevalence NN cord-010092-uftc8inx 7656 47 among among IN cord-010092-uftc8inx 7656 48 blood blood NN cord-010092-uftc8inx 7656 49 donation donation NN cord-010092-uftc8inx 7656 50 from from IN cord-010092-uftc8inx 7656 51 2015 2015 CD cord-010092-uftc8inx 7656 52 to to IN cord-010092-uftc8inx 7656 53 2017 2017 CD cord-010092-uftc8inx 7656 54 . . . cord-010092-uftc8inx 7657 1 The the DT cord-010092-uftc8inx 7657 2 prevalence prevalence NN cord-010092-uftc8inx 7657 3 of of IN cord-010092-uftc8inx 7657 4 HIV HIV NNP cord-010092-uftc8inx 7657 5 , , , cord-010092-uftc8inx 7657 6 HCV HCV NNP cord-010092-uftc8inx 7657 7 , , , cord-010092-uftc8inx 7657 8 and and CC cord-010092-uftc8inx 7657 9 HBV HBV NNP cord-010092-uftc8inx 7657 10 among among IN cord-010092-uftc8inx 7657 11 donations donation NNS cord-010092-uftc8inx 7657 12 has have VBZ cord-010092-uftc8inx 7657 13 been be VBN cord-010092-uftc8inx 7657 14 decreased decrease VBN cord-010092-uftc8inx 7657 15 significantly significantly RB cord-010092-uftc8inx 7657 16 in in IN cord-010092-uftc8inx 7657 17 2017 2017 CD cord-010092-uftc8inx 7657 18 compared compare VBN cord-010092-uftc8inx 7657 19 with with IN cord-010092-uftc8inx 7657 20 the the DT cord-010092-uftc8inx 7657 21 2015 2015 CD cord-010092-uftc8inx 7657 22 . . . cord-010092-uftc8inx 7658 1 Prevalence prevalence NN cord-010092-uftc8inx 7658 2 of of IN cord-010092-uftc8inx 7658 3 HIV HIV NNP cord-010092-uftc8inx 7658 4 among among IN cord-010092-uftc8inx 7658 5 donations donation NNS cord-010092-uftc8inx 7658 6 reduce reduce VBP cord-010092-uftc8inx 7658 7 from from IN cord-010092-uftc8inx 7658 8 0.0032 0.0032 CD cord-010092-uftc8inx 7658 9 % % NN cord-010092-uftc8inx 7658 10 in in IN cord-010092-uftc8inx 7658 11 2015 2015 CD cord-010092-uftc8inx 7658 12 to to IN cord-010092-uftc8inx 7658 13 0.0024 0.0024 CD cord-010092-uftc8inx 7658 14 % % NN cord-010092-uftc8inx 7658 15 in in IN cord-010092-uftc8inx 7658 16 2017 2017 CD cord-010092-uftc8inx 7658 17 , , , cord-010092-uftc8inx 7658 18 for for IN cord-010092-uftc8inx 7658 19 HCV HCV NNP cord-010092-uftc8inx 7658 20 and and CC cord-010092-uftc8inx 7658 21 HBV HBV NNP cord-010092-uftc8inx 7658 22 the the DT cord-010092-uftc8inx 7658 23 same same JJ cord-010092-uftc8inx 7658 24 results result NNS cord-010092-uftc8inx 7658 25 have have VBP cord-010092-uftc8inx 7658 26 been be VBN cord-010092-uftc8inx 7658 27 experienced experience VBN cord-010092-uftc8inx 7658 28 , , , cord-010092-uftc8inx 7658 29 respectively respectively RB cord-010092-uftc8inx 7658 30 from from IN cord-010092-uftc8inx 7658 31 0.040 0.040 CD cord-010092-uftc8inx 7658 32 % % NN cord-010092-uftc8inx 7658 33 and and CC cord-010092-uftc8inx 7658 34 0.113 0.113 CD cord-010092-uftc8inx 7658 35 % % NN cord-010092-uftc8inx 7658 36 in in IN cord-010092-uftc8inx 7658 37 2015 2015 CD cord-010092-uftc8inx 7658 38 reduce reduce NN cord-010092-uftc8inx 7658 39 to to IN cord-010092-uftc8inx 7658 40 0.026 0.026 CD cord-010092-uftc8inx 7658 41 % % NN cord-010092-uftc8inx 7658 42 and and CC cord-010092-uftc8inx 7658 43 0.053 0.053 CD cord-010092-uftc8inx 7658 44 % % NN cord-010092-uftc8inx 7658 45 in in IN cord-010092-uftc8inx 7658 46 2017 2017 CD cord-010092-uftc8inx 7658 47 . . . cord-010092-uftc8inx 7659 1 It -PRON- PRP cord-010092-uftc8inx 7659 2 seems seem VBZ cord-010092-uftc8inx 7659 3 this this DT cord-010092-uftc8inx 7659 4 applied applied JJ cord-010092-uftc8inx 7659 5 study study NN cord-010092-uftc8inx 7659 6 could could MD cord-010092-uftc8inx 7659 7 effectively effectively RB cord-010092-uftc8inx 7659 8 scale scale VB cord-010092-uftc8inx 7659 9 up up RP cord-010092-uftc8inx 7659 10 the the DT cord-010092-uftc8inx 7659 11 safety safety NN cord-010092-uftc8inx 7659 12 of of IN cord-010092-uftc8inx 7659 13 national national JJ cord-010092-uftc8inx 7659 14 blood blood NN cord-010092-uftc8inx 7659 15 supplies supply NNS cord-010092-uftc8inx 7659 16 . . . cord-010092-uftc8inx 7660 1 In in IN cord-010092-uftc8inx 7660 2 addition addition NN cord-010092-uftc8inx 7660 3 this this DT cord-010092-uftc8inx 7660 4 intervention intervention NN cord-010092-uftc8inx 7660 5 could could MD cord-010092-uftc8inx 7660 6 support support VB cord-010092-uftc8inx 7660 7 Iranian iranian JJ cord-010092-uftc8inx 7660 8 blood blood NN cord-010092-uftc8inx 7660 9 transfusion transfusion NN cord-010092-uftc8inx 7660 10 service service NN cord-010092-uftc8inx 7660 11 to to TO cord-010092-uftc8inx 7660 12 increase increase VB cord-010092-uftc8inx 7660 13 the the DT cord-010092-uftc8inx 7660 14 proportion proportion NN cord-010092-uftc8inx 7660 15 of of IN cord-010092-uftc8inx 7660 16 Regular regular JJ cord-010092-uftc8inx 7660 17 blood blood NN cord-010092-uftc8inx 7660 18 donors donor NNS cord-010092-uftc8inx 7660 19 from from IN cord-010092-uftc8inx 7660 20 80.19 80.19 CD cord-010092-uftc8inx 7660 21 % % NN cord-010092-uftc8inx 7660 22 in in IN cord-010092-uftc8inx 7660 23 2015 2015 CD cord-010092-uftc8inx 7660 24 to to IN cord-010092-uftc8inx 7660 25 86.97 86.97 CD cord-010092-uftc8inx 7660 26 % % NN cord-010092-uftc8inx 7660 27 in in IN cord-010092-uftc8inx 7660 28 2017 2017 CD cord-010092-uftc8inx 7660 29 . . . cord-010092-uftc8inx 7661 1 It -PRON- PRP cord-010092-uftc8inx 7661 2 means mean VBZ cord-010092-uftc8inx 7661 3 that that IN cord-010092-uftc8inx 7661 4 with with IN cord-010092-uftc8inx 7661 5 increasing increase VBG cord-010092-uftc8inx 7661 6 the the DT cord-010092-uftc8inx 7661 7 Regular Regular NNP cord-010092-uftc8inx 7661 8 Blood Blood NNP cord-010092-uftc8inx 7661 9 donor donor NN cord-010092-uftc8inx 7661 10 population population NN cord-010092-uftc8inx 7661 11 sizes size NNS cord-010092-uftc8inx 7661 12 , , , cord-010092-uftc8inx 7661 13 the the DT cord-010092-uftc8inx 7661 14 safety safety NN cord-010092-uftc8inx 7661 15 of of IN cord-010092-uftc8inx 7661 16 Iranian iranian JJ cord-010092-uftc8inx 7661 17 blood blood NN cord-010092-uftc8inx 7661 18 and and CC cord-010092-uftc8inx 7661 19 blood blood NN cord-010092-uftc8inx 7661 20 products product NNS cord-010092-uftc8inx 7661 21 will will MD cord-010092-uftc8inx 7661 22 be be VB cord-010092-uftc8inx 7661 23 more more RBR cord-010092-uftc8inx 7661 24 and and CC cord-010092-uftc8inx 7661 25 more more RBR cord-010092-uftc8inx 7661 26 scaled scale VBN cord-010092-uftc8inx 7661 27 up up RP cord-010092-uftc8inx 7661 28 . . . cord-010092-uftc8inx 7662 1 Summary Summary NNP cord-010092-uftc8inx 7662 2 / / SYM cord-010092-uftc8inx 7662 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 7662 4 : : : cord-010092-uftc8inx 7663 1 Evidence evidence NN cord-010092-uftc8inx 7663 2 based base VBN cord-010092-uftc8inx 7663 3 reports report NNS cord-010092-uftc8inx 7663 4 show show VBP cord-010092-uftc8inx 7663 5 there there EX cord-010092-uftc8inx 7663 6 is be VBZ cord-010092-uftc8inx 7663 7 a a DT cord-010092-uftc8inx 7663 8 high high JJ cord-010092-uftc8inx 7663 9 rate rate NN cord-010092-uftc8inx 7663 10 of of IN cord-010092-uftc8inx 7663 11 prevalence prevalence NN cord-010092-uftc8inx 7663 12 of of IN cord-010092-uftc8inx 7663 13 Transfusion transfusion NN cord-010092-uftc8inx 7663 14 Transmitted transmit VBN cord-010092-uftc8inx 7663 15 Infections infection NNS cord-010092-uftc8inx 7663 16 ( ( -LRB- cord-010092-uftc8inx 7663 17 TTIs tti NNS cord-010092-uftc8inx 7663 18 ) ) -RRB- cord-010092-uftc8inx 7663 19 among among IN cord-010092-uftc8inx 7663 20 first first JJ cord-010092-uftc8inx 7663 21 blood blood NN cord-010092-uftc8inx 7663 22 donors donor NNS cord-010092-uftc8inx 7663 23 . . . cord-010092-uftc8inx 7664 1 So so IN cord-010092-uftc8inx 7664 2 an an DT cord-010092-uftc8inx 7664 3 effective effective JJ cord-010092-uftc8inx 7664 4 intervention intervention NN cord-010092-uftc8inx 7664 5 which which WDT cord-010092-uftc8inx 7664 6 can can MD cord-010092-uftc8inx 7664 7 reduce reduce VB cord-010092-uftc8inx 7664 8 the the DT cord-010092-uftc8inx 7664 9 risk risk NN cord-010092-uftc8inx 7664 10 of of IN cord-010092-uftc8inx 7664 11 unsafe unsafe JJ cord-010092-uftc8inx 7664 12 first first JJ cord-010092-uftc8inx 7664 13 blood blood NN cord-010092-uftc8inx 7664 14 donation donation NN cord-010092-uftc8inx 7664 15 can can MD cord-010092-uftc8inx 7664 16 effectively effectively RB cord-010092-uftc8inx 7664 17 increase increase VB cord-010092-uftc8inx 7664 18 the the DT cord-010092-uftc8inx 7664 19 safety safety NN cord-010092-uftc8inx 7664 20 of of IN cord-010092-uftc8inx 7664 21 blood blood NN cord-010092-uftc8inx 7664 22 and and CC cord-010092-uftc8inx 7664 23 blood blood NN cord-010092-uftc8inx 7664 24 products product NNS cord-010092-uftc8inx 7664 25 . . . cord-010092-uftc8inx 7665 1 Pre Pre NNP cord-010092-uftc8inx 7665 2 Donation Donation NNP cord-010092-uftc8inx 7665 3 Screening Screening NNP cord-010092-uftc8inx 7665 4 Tests Tests NNPS cord-010092-uftc8inx 7665 5 program program NN cord-010092-uftc8inx 7665 6 in in IN cord-010092-uftc8inx 7665 7 IRAN IRAN NNP cord-010092-uftc8inx 7665 8 can can MD cord-010092-uftc8inx 7665 9 support support VB cord-010092-uftc8inx 7665 10 the the DT cord-010092-uftc8inx 7665 11 national national JJ cord-010092-uftc8inx 7665 12 program program NN cord-010092-uftc8inx 7665 13 to to TO cord-010092-uftc8inx 7665 14 decrease decrease VB cord-010092-uftc8inx 7665 15 the the DT cord-010092-uftc8inx 7665 16 rate rate NN cord-010092-uftc8inx 7665 17 of of IN cord-010092-uftc8inx 7665 18 TTIs tti NNS cord-010092-uftc8inx 7665 19 among among IN cord-010092-uftc8inx 7665 20 blood blood NN cord-010092-uftc8inx 7665 21 donations donation NNS cord-010092-uftc8inx 7665 22 from from IN cord-010092-uftc8inx 7665 23 0.0156 0.0156 CD cord-010092-uftc8inx 7665 24 % % NN cord-010092-uftc8inx 7665 25 in in IN cord-010092-uftc8inx 7665 26 2015 2015 CD cord-010092-uftc8inx 7665 27 to to IN cord-010092-uftc8inx 7665 28 .082 .082 CD cord-010092-uftc8inx 7665 29 % % NN cord-010092-uftc8inx 7665 30 in in IN cord-010092-uftc8inx 7665 31 20117 20117 CD cord-010092-uftc8inx 7665 32 . . . cord-010092-uftc8inx 7666 1 Abstract Abstract NNP cord-010092-uftc8inx 7666 2 withdrawn withdraw VBN cord-010092-uftc8inx 7666 3 . . . cord-010092-uftc8inx 7667 1 Abstract Abstract NNP cord-010092-uftc8inx 7667 2 withdrawn withdraw VBN cord-010092-uftc8inx 7667 3 . . . cord-010092-uftc8inx 7668 1 Background background NN cord-010092-uftc8inx 7668 2 : : : cord-010092-uftc8inx 7669 1 Despite despite IN cord-010092-uftc8inx 7669 2 the the DT cord-010092-uftc8inx 7669 3 universal universal JJ cord-010092-uftc8inx 7669 4 application application NN cord-010092-uftc8inx 7669 5 of of IN cord-010092-uftc8inx 7669 6 viral viral JJ cord-010092-uftc8inx 7669 7 inactivation inactivation NN cord-010092-uftc8inx 7669 8 and and CC cord-010092-uftc8inx 7669 9 elimination elimination NN cord-010092-uftc8inx 7669 10 technologies technology NNS cord-010092-uftc8inx 7669 11 during during IN cord-010092-uftc8inx 7669 12 the the DT cord-010092-uftc8inx 7669 13 preparation preparation NN cord-010092-uftc8inx 7669 14 of of IN cord-010092-uftc8inx 7669 15 plasma plasma NN cord-010092-uftc8inx 7669 16 - - HYPH cord-010092-uftc8inx 7669 17 derived derive VBN cord-010092-uftc8inx 7669 18 products product NNS cord-010092-uftc8inx 7669 19 , , , cord-010092-uftc8inx 7669 20 the the DT cord-010092-uftc8inx 7669 21 exclusion exclusion NN cord-010092-uftc8inx 7669 22 of of IN cord-010092-uftc8inx 7669 23 infectious infectious JJ cord-010092-uftc8inx 7669 24 donations donation NNS cord-010092-uftc8inx 7669 25 before before IN cord-010092-uftc8inx 7669 26 any any DT cord-010092-uftc8inx 7669 27 other other JJ cord-010092-uftc8inx 7669 28 procedure procedure NN cord-010092-uftc8inx 7669 29 remains remain VBZ cord-010092-uftc8inx 7669 30 the the DT cord-010092-uftc8inx 7669 31 first first JJ cord-010092-uftc8inx 7669 32 essential essential JJ cord-010092-uftc8inx 7669 33 step step NN cord-010092-uftc8inx 7669 34 as as RB cord-010092-uftc8inx 7669 35 well well RB cord-010092-uftc8inx 7669 36 as as IN cord-010092-uftc8inx 7669 37 the the DT cord-010092-uftc8inx 7669 38 major major JJ cord-010092-uftc8inx 7669 39 determinant determinant NN cord-010092-uftc8inx 7669 40 for for IN cord-010092-uftc8inx 7669 41 the the DT cord-010092-uftc8inx 7669 42 safety safety NN cord-010092-uftc8inx 7669 43 of of IN cord-010092-uftc8inx 7669 44 untreated untreated JJ cord-010092-uftc8inx 7669 45 labile labile JJ cord-010092-uftc8inx 7669 46 blood blood NN cord-010092-uftc8inx 7669 47 products product NNS cord-010092-uftc8inx 7669 48 . . . cord-010092-uftc8inx 7670 1 Current current JJ cord-010092-uftc8inx 7670 2 selection selection NN cord-010092-uftc8inx 7670 3 and and CC cord-010092-uftc8inx 7670 4 screening screening NN cord-010092-uftc8inx 7670 5 techniques technique NNS cord-010092-uftc8inx 7670 6 have have VBP cord-010092-uftc8inx 7670 7 reduced reduce VBN cord-010092-uftc8inx 7670 8 the the DT cord-010092-uftc8inx 7670 9 risk risk NN cord-010092-uftc8inx 7670 10 of of IN cord-010092-uftc8inx 7670 11 viral viral JJ cord-010092-uftc8inx 7670 12 transmission transmission NN cord-010092-uftc8inx 7670 13 to to IN cord-010092-uftc8inx 7670 14 very very RB cord-010092-uftc8inx 7670 15 low low JJ cord-010092-uftc8inx 7670 16 levels level NNS cord-010092-uftc8inx 7670 17 , , , cord-010092-uftc8inx 7670 18 but but CC cord-010092-uftc8inx 7670 19 there there EX cord-010092-uftc8inx 7670 20 is be VBZ cord-010092-uftc8inx 7670 21 still still RB cord-010092-uftc8inx 7670 22 a a DT cord-010092-uftc8inx 7670 23 very very RB cord-010092-uftc8inx 7670 24 low low JJ cord-010092-uftc8inx 7670 25 but but CC cord-010092-uftc8inx 7670 26 quantifiable quantifiable JJ cord-010092-uftc8inx 7670 27 risk risk NN cord-010092-uftc8inx 7670 28 of of IN cord-010092-uftc8inx 7670 29 transmission transmission NN cord-010092-uftc8inx 7670 30 through through IN cord-010092-uftc8inx 7670 31 donations donation NNS cord-010092-uftc8inx 7670 32 beyond beyond IN cord-010092-uftc8inx 7670 33 routine routine JJ cord-010092-uftc8inx 7670 34 detection detection NN cord-010092-uftc8inx 7670 35 , , , cord-010092-uftc8inx 7670 36 particularly particularly RB cord-010092-uftc8inx 7670 37 during during IN cord-010092-uftc8inx 7670 38 the the DT cord-010092-uftc8inx 7670 39 " " `` cord-010092-uftc8inx 7670 40 seroconversion seroconversion NN cord-010092-uftc8inx 7670 41 window window NN cord-010092-uftc8inx 7670 42 " " '' cord-010092-uftc8inx 7670 43 . . . cord-010092-uftc8inx 7670 44 " " '' cord-010092-uftc8inx 7670 45 of of IN cord-010092-uftc8inx 7670 46 an an DT cord-010092-uftc8inx 7670 47 infection infection NN cord-010092-uftc8inx 7670 48 in in IN cord-010092-uftc8inx 7670 49 a a DT cord-010092-uftc8inx 7670 50 blood blood NN cord-010092-uftc8inx 7670 51 donor donor NN cord-010092-uftc8inx 7670 52 that that WDT cord-010092-uftc8inx 7670 53 is be VBZ cord-010092-uftc8inx 7670 54 to to TO cord-010092-uftc8inx 7670 55 say say VB cord-010092-uftc8inx 7670 56 during during IN cord-010092-uftc8inx 7670 57 the the DT cord-010092-uftc8inx 7670 58 period period NN cord-010092-uftc8inx 7670 59 when when WRB cord-010092-uftc8inx 7670 60 the the DT cord-010092-uftc8inx 7670 61 recently recently RB cord-010092-uftc8inx 7670 62 infected infect VBN cord-010092-uftc8inx 7670 63 donor donor NN cord-010092-uftc8inx 7670 64 has have VBZ cord-010092-uftc8inx 7670 65 not not RB cord-010092-uftc8inx 7670 66 yet yet RB cord-010092-uftc8inx 7670 67 developed develop VBN cord-010092-uftc8inx 7670 68 a a DT cord-010092-uftc8inx 7670 69 serological serological JJ cord-010092-uftc8inx 7670 70 response response NN cord-010092-uftc8inx 7670 71 . . . cord-010092-uftc8inx 7671 1 The the DT cord-010092-uftc8inx 7671 2 level level NN cord-010092-uftc8inx 7671 3 of of IN cord-010092-uftc8inx 7671 4 residual residual JJ cord-010092-uftc8inx 7671 5 risk risk NN cord-010092-uftc8inx 7671 6 , , , cord-010092-uftc8inx 7671 7 which which WDT cord-010092-uftc8inx 7671 8 must must MD cord-010092-uftc8inx 7671 9 be be VB cord-010092-uftc8inx 7671 10 as as RB cord-010092-uftc8inx 7671 11 low low JJ cord-010092-uftc8inx 7671 12 as as IN cord-010092-uftc8inx 7671 13 possible possible JJ cord-010092-uftc8inx 7671 14 , , , cord-010092-uftc8inx 7671 15 is be VBZ cord-010092-uftc8inx 7671 16 mainly mainly RB cord-010092-uftc8inx 7671 17 conditioned condition VBN cord-010092-uftc8inx 7671 18 by by IN cord-010092-uftc8inx 7671 19 the the DT cord-010092-uftc8inx 7671 20 rates rate NNS cord-010092-uftc8inx 7671 21 of of IN cord-010092-uftc8inx 7671 22 the the DT cord-010092-uftc8inx 7671 23 infections infection NNS cord-010092-uftc8inx 7671 24 concerned concern VBN cord-010092-uftc8inx 7671 25 ( ( -LRB- cord-010092-uftc8inx 7671 26 HIV HIV NNP cord-010092-uftc8inx 7671 27 and and CC cord-010092-uftc8inx 7671 28 hepatitis hepatitis NNP cord-010092-uftc8inx 7671 29 B B NNP cord-010092-uftc8inx 7671 30 virus virus NN cord-010092-uftc8inx 7671 31 ( ( -LRB- cord-010092-uftc8inx 7671 32 HBV HBV NNP cord-010092-uftc8inx 7671 33 ) ) -RRB- cord-010092-uftc8inx 7671 34 and and CC cord-010092-uftc8inx 7671 35 C C NNP cord-010092-uftc8inx 7671 36 ( ( -LRB- cord-010092-uftc8inx 7671 37 HCV HCV NNP cord-010092-uftc8inx 7671 38 ) ) -RRB- cord-010092-uftc8inx 7671 39 ) ) -RRB- cord-010092-uftc8inx 7671 40 to to IN cord-010092-uftc8inx 7671 41 blood blood NN cord-010092-uftc8inx 7671 42 donors donor NNS cord-010092-uftc8inx 7671 43 . . . cord-010092-uftc8inx 7672 1 Summary Summary NNP cord-010092-uftc8inx 7672 2 / / SYM cord-010092-uftc8inx 7672 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 7672 4 : : : cord-010092-uftc8inx 7673 1 The the DT cord-010092-uftc8inx 7673 2 evolution evolution NN cord-010092-uftc8inx 7673 3 of of IN cord-010092-uftc8inx 7673 4 serologic serologic JJ cord-010092-uftc8inx 7673 5 markers marker NNS cord-010092-uftc8inx 7673 6 is be VBZ cord-010092-uftc8inx 7673 7 generally generally RB cord-010092-uftc8inx 7673 8 satisfactory satisfactory JJ cord-010092-uftc8inx 7673 9 with with IN cord-010092-uftc8inx 7673 10 continued continued JJ cord-010092-uftc8inx 7673 11 regression regression NN cord-010092-uftc8inx 7673 12 , , , cord-010092-uftc8inx 7673 13 which which WDT cord-010092-uftc8inx 7673 14 has have VBZ cord-010092-uftc8inx 7673 15 improved improve VBN cord-010092-uftc8inx 7673 16 particularly particularly RB cord-010092-uftc8inx 7673 17 for for IN cord-010092-uftc8inx 7673 18 HIV HIV NNP cord-010092-uftc8inx 7673 19 . . . cord-010092-uftc8inx 7674 1 On on IN cord-010092-uftc8inx 7674 2 the the DT cord-010092-uftc8inx 7674 3 other other JJ cord-010092-uftc8inx 7674 4 hand hand NN cord-010092-uftc8inx 7674 5 , , , cord-010092-uftc8inx 7674 6 hepatitis hepatitis NNP cord-010092-uftc8inx 7674 7 B B NNP cord-010092-uftc8inx 7674 8 is be VBZ cord-010092-uftc8inx 7674 9 still still RB cord-010092-uftc8inx 7674 10 a a DT cord-010092-uftc8inx 7674 11 concern concern NN cord-010092-uftc8inx 7674 12 because because IN cord-010092-uftc8inx 7674 13 of of IN cord-010092-uftc8inx 7674 14 its -PRON- PRP$ cord-010092-uftc8inx 7674 15 still still RB cord-010092-uftc8inx 7674 16 high high JJ cord-010092-uftc8inx 7674 17 rate rate NN cord-010092-uftc8inx 7674 18 among among IN cord-010092-uftc8inx 7674 19 new new JJ cord-010092-uftc8inx 7674 20 donors donor NNS cord-010092-uftc8inx 7674 21 . . . cord-010092-uftc8inx 7675 1 It -PRON- PRP cord-010092-uftc8inx 7675 2 is be VBZ cord-010092-uftc8inx 7675 3 desirable desirable JJ cord-010092-uftc8inx 7675 4 to to TO cord-010092-uftc8inx 7675 5 initiate initiate VB cord-010092-uftc8inx 7675 6 a a DT cord-010092-uftc8inx 7675 7 regular regular JJ cord-010092-uftc8inx 7675 8 donor donor NN cord-010092-uftc8inx 7675 9 vaccination vaccination NN cord-010092-uftc8inx 7675 10 program program NN cord-010092-uftc8inx 7675 11 to to TO cord-010092-uftc8inx 7675 12 protect protect VB cord-010092-uftc8inx 7675 13 against against IN cord-010092-uftc8inx 7675 14 hepatitis hepatitis NNP cord-010092-uftc8inx 7675 15 B. B. NNP cord-010092-uftc8inx 7675 16 Background Background NNP cord-010092-uftc8inx 7675 17 : : : cord-010092-uftc8inx 7675 18 Blood blood NN cord-010092-uftc8inx 7675 19 centres centre NNS cord-010092-uftc8inx 7675 20 require require VBP cord-010092-uftc8inx 7675 21 high high JJ cord-010092-uftc8inx 7675 22 throughput throughput NN cord-010092-uftc8inx 7675 23 assays assay NNS cord-010092-uftc8inx 7675 24 with with IN cord-010092-uftc8inx 7675 25 a a DT cord-010092-uftc8inx 7675 26 high high JJ cord-010092-uftc8inx 7675 27 level level NN cord-010092-uftc8inx 7675 28 of of IN cord-010092-uftc8inx 7675 29 reproducibility reproducibility NN cord-010092-uftc8inx 7675 30 to to TO cord-010092-uftc8inx 7675 31 assure assure VB cord-010092-uftc8inx 7675 32 consistent consistent JJ cord-010092-uftc8inx 7675 33 results result NNS cord-010092-uftc8inx 7675 34 and and CC cord-010092-uftc8inx 7675 35 minimize minimize VB cord-010092-uftc8inx 7675 36 unnecessary unnecessary JJ cord-010092-uftc8inx 7675 37 retesting retesting NN cord-010092-uftc8inx 7675 38 of of IN cord-010092-uftc8inx 7675 39 samples sample NNS cord-010092-uftc8inx 7675 40 and and CC cord-010092-uftc8inx 7675 41 deferral deferral NN cord-010092-uftc8inx 7675 42 of of IN cord-010092-uftc8inx 7675 43 donors donor NNS cord-010092-uftc8inx 7675 44 . . . cord-010092-uftc8inx 7676 1 In in IN cord-010092-uftc8inx 7676 2 addition addition NN cord-010092-uftc8inx 7676 3 , , , cord-010092-uftc8inx 7676 4 continued continue VBN cord-010092-uftc8inx 7676 5 economic economic JJ cord-010092-uftc8inx 7676 6 pressures pressure NNS cord-010092-uftc8inx 7676 7 on on IN cord-010092-uftc8inx 7676 8 laboratory laboratory NN cord-010092-uftc8inx 7676 9 operations operation NNS cord-010092-uftc8inx 7676 10 demand demand VBP cord-010092-uftc8inx 7676 11 that that IN cord-010092-uftc8inx 7676 12 assays assay NNS cord-010092-uftc8inx 7676 13 perform perform VBP cord-010092-uftc8inx 7676 14 on on IN cord-010092-uftc8inx 7676 15 platforms platform NNS cord-010092-uftc8inx 7676 16 capable capable JJ cord-010092-uftc8inx 7676 17 of of IN cord-010092-uftc8inx 7676 18 increased increase VBN cord-010092-uftc8inx 7676 19 walk walk NN cord-010092-uftc8inx 7676 20 away away RB cord-010092-uftc8inx 7676 21 time time NN cord-010092-uftc8inx 7676 22 and and CC cord-010092-uftc8inx 7676 23 enhanced enhanced JJ cord-010092-uftc8inx 7676 24 automation automation NN cord-010092-uftc8inx 7676 25 in in IN cord-010092-uftc8inx 7676 26 areas area NNS cord-010092-uftc8inx 7676 27 of of IN cord-010092-uftc8inx 7676 28 reagent reagent NN cord-010092-uftc8inx 7676 29 management management NN cord-010092-uftc8inx 7676 30 , , , cord-010092-uftc8inx 7676 31 retest retest VB cord-010092-uftc8inx 7676 32 options option NNS cord-010092-uftc8inx 7676 33 , , , cord-010092-uftc8inx 7676 34 and and CC cord-010092-uftc8inx 7676 35 commodity commodity NN cord-010092-uftc8inx 7676 36 / / SYM cord-010092-uftc8inx 7676 37 waste waste NN cord-010092-uftc8inx 7676 38 management management NN cord-010092-uftc8inx 7676 39 . . . cord-010092-uftc8inx 7677 1 Aims aim NNS cord-010092-uftc8inx 7677 2 : : : cord-010092-uftc8inx 7677 3 Evaluate evaluate VB cord-010092-uftc8inx 7677 4 the the DT cord-010092-uftc8inx 7677 5 reproducibility reproducibility NN cord-010092-uftc8inx 7677 6 of of IN cord-010092-uftc8inx 7677 7 HCVab HCVab NNPS cord-010092-uftc8inx 7677 8 , , , cord-010092-uftc8inx 7677 9 HAVab HAVab NNP cord-010092-uftc8inx 7677 10 IgM IgM NNP cord-010092-uftc8inx 7677 11 and and CC cord-010092-uftc8inx 7677 12 HAVab HAVab NNP cord-010092-uftc8inx 7677 13 IgG IgG NNP cord-010092-uftc8inx 7677 14 essays essay NNS cord-010092-uftc8inx 7677 15 using use VBG cord-010092-uftc8inx 7677 16 Abbott Abbott NNP cord-010092-uftc8inx 7677 17 Alinity Alinity NNP cord-010092-uftc8inx 7677 18 S S NNP cord-010092-uftc8inx 7677 19 when when WRB cord-010092-uftc8inx 7677 20 compared compare VBN cord-010092-uftc8inx 7677 21 to to IN cord-010092-uftc8inx 7677 22 Architect Architect NNP cord-010092-uftc8inx 7677 23 i2000SR i2000sr JJ cord-010092-uftc8inx 7677 24 . . . cord-010092-uftc8inx 7678 1 Determine determine VB cord-010092-uftc8inx 7678 2 repeatability repeatability NN cord-010092-uftc8inx 7678 3 of of IN cord-010092-uftc8inx 7678 4 these these DT cord-010092-uftc8inx 7678 5 tests test NNS cord-010092-uftc8inx 7678 6 in in IN cord-010092-uftc8inx 7678 7 Alinity Alinity NNP cord-010092-uftc8inx 7678 8 S S NNP cord-010092-uftc8inx 7678 9 essays essay NNS cord-010092-uftc8inx 7678 10 . . . cord-010092-uftc8inx 7679 1 Methods method NNS cord-010092-uftc8inx 7679 2 : : : cord-010092-uftc8inx 7679 3 During during IN cord-010092-uftc8inx 7679 4 2 2 CD cord-010092-uftc8inx 7679 5 months month NNS cord-010092-uftc8inx 7679 6 a a DT cord-010092-uftc8inx 7679 7 study study NN cord-010092-uftc8inx 7679 8 was be VBD cord-010092-uftc8inx 7679 9 conducted conduct VBN cord-010092-uftc8inx 7679 10 where where WRB cord-010092-uftc8inx 7679 11 several several JJ cord-010092-uftc8inx 7679 12 samples sample NNS cord-010092-uftc8inx 7679 13 ( ( -LRB- cord-010092-uftc8inx 7679 14 minimum minimum JJ cord-010092-uftc8inx 7679 15 10 10 CD cord-010092-uftc8inx 7679 16 samples sample NNS cord-010092-uftc8inx 7679 17 per per IN cord-010092-uftc8inx 7679 18 test test NN cord-010092-uftc8inx 7679 19 ) ) -RRB- cord-010092-uftc8inx 7679 20 were be VBD cord-010092-uftc8inx 7679 21 randomly randomly RB cord-010092-uftc8inx 7679 22 sorted sort VBN cord-010092-uftc8inx 7679 23 and and CC cord-010092-uftc8inx 7679 24 tested test VBD cord-010092-uftc8inx 7679 25 using use VBG cord-010092-uftc8inx 7679 26 Alinity Alinity NNP cord-010092-uftc8inx 7679 27 S S NNP cord-010092-uftc8inx 7679 28 and and CC cord-010092-uftc8inx 7679 29 Architect Architect NNP cord-010092-uftc8inx 7679 30 i2000SR i2000sr JJ cord-010092-uftc8inx 7679 31 , , , cord-010092-uftc8inx 7679 32 results result NNS cord-010092-uftc8inx 7679 33 were be VBD cord-010092-uftc8inx 7679 34 compared compare VBN cord-010092-uftc8inx 7679 35 using use VBG cord-010092-uftc8inx 7679 36 IBM IBM NNP cord-010092-uftc8inx 7679 37 SPSS SPSS NNP cord-010092-uftc8inx 7679 38 Statistics Statistics NNP cord-010092-uftc8inx 7679 39 â â NNP cord-010092-uftc8inx 7679 40 . . . cord-010092-uftc8inx 7680 1 In in IN cord-010092-uftc8inx 7680 2 order order NN cord-010092-uftc8inx 7680 3 to to TO cord-010092-uftc8inx 7680 4 evaluate evaluate VB cord-010092-uftc8inx 7680 5 repeatability repeatability NN cord-010092-uftc8inx 7680 6 , , , cord-010092-uftc8inx 7680 7 at at IN cord-010092-uftc8inx 7680 8 least least JJS cord-010092-uftc8inx 7680 9 3 3 CD cord-010092-uftc8inx 7680 10 samples sample NNS cord-010092-uftc8inx 7680 11 with with IN cord-010092-uftc8inx 7680 12 different different JJ cord-010092-uftc8inx 7680 13 reactive reactive JJ cord-010092-uftc8inx 7680 14 degrees degree NNS cord-010092-uftc8inx 7680 15 ( ( -LRB- cord-010092-uftc8inx 7680 16 high high JJ cord-010092-uftc8inx 7680 17 , , , cord-010092-uftc8inx 7680 18 intermediate intermediate JJ cord-010092-uftc8inx 7680 19 and and CC cord-010092-uftc8inx 7680 20 low low JJ cord-010092-uftc8inx 7680 21 ) ) -RRB- cord-010092-uftc8inx 7680 22 per per IN cord-010092-uftc8inx 7680 23 test test NN cord-010092-uftc8inx 7680 24 were be VBD cord-010092-uftc8inx 7680 25 repeated repeat VBN cord-010092-uftc8inx 7680 26 , , , cord-010092-uftc8inx 7680 27 using use VBG cord-010092-uftc8inx 7680 28 Alinity Alinity NNP cord-010092-uftc8inx 7680 29 S S NNP cord-010092-uftc8inx 7680 30 , , , cord-010092-uftc8inx 7680 31 an an DT cord-010092-uftc8inx 7680 32 average average NN cord-010092-uftc8inx 7680 33 of of IN cord-010092-uftc8inx 7680 34 10 10 CD cord-010092-uftc8inx 7680 35 times time NNS cord-010092-uftc8inx 7680 36 per per IN cord-010092-uftc8inx 7680 37 sample sample NN cord-010092-uftc8inx 7680 38 and and CC cord-010092-uftc8inx 7680 39 it -PRON- PRP cord-010092-uftc8inx 7680 40 was be VBD cord-010092-uftc8inx 7680 41 determined determine VBN cord-010092-uftc8inx 7680 42 the the DT cord-010092-uftc8inx 7680 43 percentage percentage NN cord-010092-uftc8inx 7680 44 of of IN cord-010092-uftc8inx 7680 45 coefficient coefficient NN cord-010092-uftc8inx 7680 46 of of IN cord-010092-uftc8inx 7680 47 variation variation NN cord-010092-uftc8inx 7680 48 ( ( -LRB- cord-010092-uftc8inx 7680 49 % % NN cord-010092-uftc8inx 7680 50 CV CV NNP cord-010092-uftc8inx 7680 51 ) ) -RRB- cord-010092-uftc8inx 7680 52 . . . cord-010092-uftc8inx 7681 1 Results result NNS cord-010092-uftc8inx 7681 2 : : : cord-010092-uftc8inx 7682 1 A a DT cord-010092-uftc8inx 7682 2 total total NN cord-010092-uftc8inx 7682 3 of of IN cord-010092-uftc8inx 7682 4 61 61 CD cord-010092-uftc8inx 7682 5 samples sample NNS cord-010092-uftc8inx 7682 6 were be VBD cord-010092-uftc8inx 7682 7 tested test VBN cord-010092-uftc8inx 7682 8 ( ( -LRB- cord-010092-uftc8inx 7682 9 19 19 CD cord-010092-uftc8inx 7682 10 for for IN cord-010092-uftc8inx 7682 11 HCVab HCVab NNPS cord-010092-uftc8inx 7682 12 , , , cord-010092-uftc8inx 7682 13 24 24 CD cord-010092-uftc8inx 7682 14 for for IN cord-010092-uftc8inx 7682 15 HAVab HAVab NNP cord-010092-uftc8inx 7682 16 IgM IgM NNP cord-010092-uftc8inx 7682 17 and and CC cord-010092-uftc8inx 7682 18 18 18 CD cord-010092-uftc8inx 7682 19 for for IN cord-010092-uftc8inx 7682 20 HAVab HAVab NNP cord-010092-uftc8inx 7682 21 IgG IgG NNP cord-010092-uftc8inx 7682 22 ) ) -RRB- cord-010092-uftc8inx 7682 23 using use VBG cord-010092-uftc8inx 7682 24 Alinity Alinity NNP cord-010092-uftc8inx 7682 25 S S NNP cord-010092-uftc8inx 7682 26 and and CC cord-010092-uftc8inx 7682 27 Architect Architect NNP cord-010092-uftc8inx 7682 28 i2000SR i2000sr JJ cord-010092-uftc8inx 7682 29 , , , cord-010092-uftc8inx 7682 30 and and CC cord-010092-uftc8inx 7682 31 it -PRON- PRP cord-010092-uftc8inx 7682 32 was be VBD cord-010092-uftc8inx 7682 33 ensured ensure VBN cord-010092-uftc8inx 7682 34 that that IN cord-010092-uftc8inx 7682 35 there there EX cord-010092-uftc8inx 7682 36 were be VBD cord-010092-uftc8inx 7682 37 no no DT cord-010092-uftc8inx 7682 38 statistically statistically RB cord-010092-uftc8inx 7682 39 significant significant JJ cord-010092-uftc8inx 7682 40 differences difference NNS cord-010092-uftc8inx 7682 41 between between IN cord-010092-uftc8inx 7682 42 results result NNS cord-010092-uftc8inx 7682 43 ( ( -LRB- cord-010092-uftc8inx 7682 44 P p NN cord-010092-uftc8inx 7682 45 > > XX cord-010092-uftc8inx 7682 46 .05 .05 NFP cord-010092-uftc8inx 7682 47 ) ) -RRB- cord-010092-uftc8inx 7682 48 . . . cord-010092-uftc8inx 7683 1 Using use VBG cord-010092-uftc8inx 7683 2 3 3 CD cord-010092-uftc8inx 7683 3 samples sample NNS cord-010092-uftc8inx 7683 4 and and CC cord-010092-uftc8inx 7683 5 a a DT cord-010092-uftc8inx 7683 6 total total NN cord-010092-uftc8inx 7683 7 of of IN cord-010092-uftc8inx 7683 8 31 31 CD cord-010092-uftc8inx 7683 9 essays essay NNS cord-010092-uftc8inx 7683 10 we -PRON- PRP cord-010092-uftc8inx 7683 11 found find VBD cord-010092-uftc8inx 7683 12 the the DT cord-010092-uftc8inx 7683 13 % % NN cord-010092-uftc8inx 7683 14 CV cv NN cord-010092-uftc8inx 7683 15 HCVab HCVab NNS cord-010092-uftc8inx 7683 16 ranged range VBD cord-010092-uftc8inx 7683 17 from from IN cord-010092-uftc8inx 7683 18 0 0 CD cord-010092-uftc8inx 7683 19 to to IN cord-010092-uftc8inx 7683 20 4.474 4.474 CD cord-010092-uftc8inx 7683 21 % % NN cord-010092-uftc8inx 7683 22 . . . cord-010092-uftc8inx 7684 1 5 5 CD cord-010092-uftc8inx 7684 2 samples sample NNS cord-010092-uftc8inx 7684 3 were be VBD cord-010092-uftc8inx 7684 4 tested test VBN cord-010092-uftc8inx 7684 5 for for IN cord-010092-uftc8inx 7684 6 HAVab HAVab NNP cord-010092-uftc8inx 7684 7 IgM IgM NNP cord-010092-uftc8inx 7684 8 in in IN cord-010092-uftc8inx 7684 9 a a DT cord-010092-uftc8inx 7684 10 total total NN cord-010092-uftc8inx 7684 11 of of IN cord-010092-uftc8inx 7684 12 55 55 CD cord-010092-uftc8inx 7684 13 essays essay NNS cord-010092-uftc8inx 7684 14 and and CC cord-010092-uftc8inx 7684 15 the the DT cord-010092-uftc8inx 7684 16 % % NN cord-010092-uftc8inx 7684 17 CV cv NN cord-010092-uftc8inx 7684 18 ranged range VBD cord-010092-uftc8inx 7684 19 from from IN cord-010092-uftc8inx 7684 20 0 0 CD cord-010092-uftc8inx 7684 21 to to IN cord-010092-uftc8inx 7684 22 11.475 11.475 CD cord-010092-uftc8inx 7684 23 % % NN cord-010092-uftc8inx 7684 24 . . . cord-010092-uftc8inx 7685 1 HAVab HAVab NNP cord-010092-uftc8inx 7685 2 IgG igg NN cord-010092-uftc8inx 7685 3 was be VBD cord-010092-uftc8inx 7685 4 tested test VBN cord-010092-uftc8inx 7685 5 in in IN cord-010092-uftc8inx 7685 6 3 3 CD cord-010092-uftc8inx 7685 7 samples sample NNS cord-010092-uftc8inx 7685 8 during during IN cord-010092-uftc8inx 7685 9 33 33 CD cord-010092-uftc8inx 7685 10 essays essay NNS cord-010092-uftc8inx 7685 11 and and CC cord-010092-uftc8inx 7685 12 the the DT cord-010092-uftc8inx 7685 13 % % NN cord-010092-uftc8inx 7685 14 CV cv NN cord-010092-uftc8inx 7685 15 ranged range VBD cord-010092-uftc8inx 7685 16 from from IN cord-010092-uftc8inx 7685 17 0 0 CD cord-010092-uftc8inx 7685 18 to to IN cord-010092-uftc8inx 7685 19 4.861 4.861 CD cord-010092-uftc8inx 7685 20 % % NN cord-010092-uftc8inx 7685 21 . . . cord-010092-uftc8inx 7686 1 Summary Summary NNP cord-010092-uftc8inx 7686 2 / / SYM cord-010092-uftc8inx 7686 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 7686 4 : : : cord-010092-uftc8inx 7687 1 The the DT cord-010092-uftc8inx 7687 2 new new JJ cord-010092-uftc8inx 7687 3 automated automate VBN cord-010092-uftc8inx 7687 4 equipment equipment NN cord-010092-uftc8inx 7687 5 Alinity Alinity NNP cord-010092-uftc8inx 7687 6 S S NNP cord-010092-uftc8inx 7687 7 system system NN cord-010092-uftc8inx 7687 8 demonstrated demonstrate VBD cord-010092-uftc8inx 7687 9 no no DT cord-010092-uftc8inx 7687 10 statistically statistically RB cord-010092-uftc8inx 7687 11 difference difference NN cord-010092-uftc8inx 7687 12 when when WRB cord-010092-uftc8inx 7687 13 compared compare VBN cord-010092-uftc8inx 7687 14 with with IN cord-010092-uftc8inx 7687 15 Architect Architect NNP cord-010092-uftc8inx 7687 16 i2000SR i2000sr JJ cord-010092-uftc8inx 7687 17 and and CC cord-010092-uftc8inx 7687 18 repeatability repeatability NN cord-010092-uftc8inx 7687 19 was be VBD cord-010092-uftc8inx 7687 20 ensured ensure VBN cord-010092-uftc8inx 7687 21 . . . cord-010092-uftc8inx 7688 1 This this DT cord-010092-uftc8inx 7688 2 demonstrates demonstrate VBZ cord-010092-uftc8inx 7688 3 the the DT cord-010092-uftc8inx 7688 4 precision precision NN cord-010092-uftc8inx 7688 5 of of IN cord-010092-uftc8inx 7688 6 results result NNS cord-010092-uftc8inx 7688 7 generated generate VBN cord-010092-uftc8inx 7688 8 by by IN cord-010092-uftc8inx 7688 9 this this DT cord-010092-uftc8inx 7688 10 fully fully RB cord-010092-uftc8inx 7688 11 automated automate VBN cord-010092-uftc8inx 7688 12 blood blood NN cord-010092-uftc8inx 7688 13 screening screening NN cord-010092-uftc8inx 7688 14 analyzer analyzer NN cord-010092-uftc8inx 7688 15 , , , cord-010092-uftc8inx 7688 16 which which WDT cord-010092-uftc8inx 7688 17 helps help VBZ cord-010092-uftc8inx 7688 18 assure assure VB cord-010092-uftc8inx 7688 19 consistent consistent JJ cord-010092-uftc8inx 7688 20 results result NNS cord-010092-uftc8inx 7688 21 for for IN cord-010092-uftc8inx 7688 22 the the DT cord-010092-uftc8inx 7688 23 testing testing NN cord-010092-uftc8inx 7688 24 and and CC cord-010092-uftc8inx 7688 25 retesting retesting NN cord-010092-uftc8inx 7688 26 of of IN cord-010092-uftc8inx 7688 27 blood blood NN cord-010092-uftc8inx 7688 28 specimens specimen NNS cord-010092-uftc8inx 7688 29 for for IN cord-010092-uftc8inx 7688 30 HCVab HCVab NNPS cord-010092-uftc8inx 7688 31 , , , cord-010092-uftc8inx 7688 32 HAVab HAVab NNP cord-010092-uftc8inx 7688 33 IgM IgM NNP cord-010092-uftc8inx 7688 34 and and CC cord-010092-uftc8inx 7689 1 HAVab HAVab NNP cord-010092-uftc8inx 7689 2 IgG. IgG. NNP cord-010092-uftc8inx 7689 3 Background background NN cord-010092-uftc8inx 7689 4 : : : cord-010092-uftc8inx 7689 5 Blood blood NN cord-010092-uftc8inx 7689 6 centres centre NNS cord-010092-uftc8inx 7689 7 require require VBP cord-010092-uftc8inx 7689 8 high high JJ cord-010092-uftc8inx 7689 9 throughput throughput NN cord-010092-uftc8inx 7689 10 assays assay NNS cord-010092-uftc8inx 7689 11 with with IN cord-010092-uftc8inx 7689 12 a a DT cord-010092-uftc8inx 7689 13 high high JJ cord-010092-uftc8inx 7689 14 level level NN cord-010092-uftc8inx 7689 15 of of IN cord-010092-uftc8inx 7689 16 reproducibility reproducibility NN cord-010092-uftc8inx 7689 17 to to TO cord-010092-uftc8inx 7689 18 assure assure VB cord-010092-uftc8inx 7689 19 consistent consistent JJ cord-010092-uftc8inx 7689 20 results result NNS cord-010092-uftc8inx 7689 21 and and CC cord-010092-uftc8inx 7689 22 minimize minimize VB cord-010092-uftc8inx 7689 23 unnecessary unnecessary JJ cord-010092-uftc8inx 7689 24 retesting retesting NN cord-010092-uftc8inx 7689 25 of of IN cord-010092-uftc8inx 7689 26 samples sample NNS cord-010092-uftc8inx 7689 27 and and CC cord-010092-uftc8inx 7689 28 deferral deferral NN cord-010092-uftc8inx 7689 29 of of IN cord-010092-uftc8inx 7689 30 donors donor NNS cord-010092-uftc8inx 7689 31 . . . cord-010092-uftc8inx 7690 1 In in IN cord-010092-uftc8inx 7690 2 addition addition NN cord-010092-uftc8inx 7690 3 , , , cord-010092-uftc8inx 7690 4 continued continue VBN cord-010092-uftc8inx 7690 5 economic economic JJ cord-010092-uftc8inx 7690 6 pressures pressure NNS cord-010092-uftc8inx 7690 7 on on IN cord-010092-uftc8inx 7690 8 laboratory laboratory NN cord-010092-uftc8inx 7690 9 operations operation NNS cord-010092-uftc8inx 7690 10 demand demand VBP cord-010092-uftc8inx 7690 11 that that IN cord-010092-uftc8inx 7690 12 assays assay NNS cord-010092-uftc8inx 7690 13 perform perform VBP cord-010092-uftc8inx 7690 14 on on IN cord-010092-uftc8inx 7690 15 platforms platform NNS cord-010092-uftc8inx 7690 16 capable capable JJ cord-010092-uftc8inx 7690 17 of of IN cord-010092-uftc8inx 7690 18 increased increase VBN cord-010092-uftc8inx 7690 19 walk walk NN cord-010092-uftc8inx 7690 20 away away RB cord-010092-uftc8inx 7690 21 time time NN cord-010092-uftc8inx 7690 22 and and CC cord-010092-uftc8inx 7690 23 enhanced enhanced JJ cord-010092-uftc8inx 7690 24 automation automation NN cord-010092-uftc8inx 7690 25 in in IN cord-010092-uftc8inx 7690 26 areas area NNS cord-010092-uftc8inx 7690 27 of of IN cord-010092-uftc8inx 7690 28 reagent reagent NN cord-010092-uftc8inx 7690 29 management management NN cord-010092-uftc8inx 7690 30 , , , cord-010092-uftc8inx 7690 31 retest retest VB cord-010092-uftc8inx 7690 32 options option NNS cord-010092-uftc8inx 7690 33 , , , cord-010092-uftc8inx 7690 34 and and CC cord-010092-uftc8inx 7690 35 commodity commodity NN cord-010092-uftc8inx 7690 36 / / SYM cord-010092-uftc8inx 7690 37 waste waste NN cord-010092-uftc8inx 7690 38 management management NN cord-010092-uftc8inx 7690 39 . . . cord-010092-uftc8inx 7691 1 Aims aim NNS cord-010092-uftc8inx 7691 2 : : : cord-010092-uftc8inx 7691 3 Evaluate evaluate VB cord-010092-uftc8inx 7691 4 the the DT cord-010092-uftc8inx 7691 5 reproducibility reproducibility NN cord-010092-uftc8inx 7691 6 of of IN cord-010092-uftc8inx 7691 7 Hbsag Hbsag NNP cord-010092-uftc8inx 7691 8 , , , cord-010092-uftc8inx 7691 9 Hbsab Hbsab NNP cord-010092-uftc8inx 7691 10 , , , cord-010092-uftc8inx 7691 11 Hbcab Hbcab NNP cord-010092-uftc8inx 7691 12 , , , cord-010092-uftc8inx 7691 13 Hbeag Hbeag NNP cord-010092-uftc8inx 7691 14 and and CC cord-010092-uftc8inx 7691 15 Hbeab Hbeab NNP cord-010092-uftc8inx 7691 16 essays essay NNS cord-010092-uftc8inx 7691 17 using use VBG cord-010092-uftc8inx 7691 18 Abbott Abbott NNP cord-010092-uftc8inx 7691 19 Alinity Alinity NNP cord-010092-uftc8inx 7691 20 S S NNP cord-010092-uftc8inx 7691 21 when when WRB cord-010092-uftc8inx 7691 22 compared compare VBN cord-010092-uftc8inx 7691 23 to to IN cord-010092-uftc8inx 7691 24 Architect Architect NNP cord-010092-uftc8inx 7691 25 i2000SR i2000sr JJ cord-010092-uftc8inx 7691 26 . . . cord-010092-uftc8inx 7692 1 Determine determine VB cord-010092-uftc8inx 7692 2 repeatability repeatability NN cord-010092-uftc8inx 7692 3 of of IN cord-010092-uftc8inx 7692 4 these these DT cord-010092-uftc8inx 7692 5 tests test NNS cord-010092-uftc8inx 7692 6 in in IN cord-010092-uftc8inx 7692 7 Alinity Alinity NNP cord-010092-uftc8inx 7692 8 S S NNP cord-010092-uftc8inx 7692 9 essays essay NNS cord-010092-uftc8inx 7692 10 . . . cord-010092-uftc8inx 7693 1 Methods method NNS cord-010092-uftc8inx 7693 2 : : : cord-010092-uftc8inx 7693 3 During during IN cord-010092-uftc8inx 7693 4 2 2 CD cord-010092-uftc8inx 7693 5 months month NNS cord-010092-uftc8inx 7693 6 a a DT cord-010092-uftc8inx 7693 7 study study NN cord-010092-uftc8inx 7693 8 was be VBD cord-010092-uftc8inx 7693 9 conducted conduct VBN cord-010092-uftc8inx 7693 10 where where WRB cord-010092-uftc8inx 7693 11 several several JJ cord-010092-uftc8inx 7693 12 samples sample NNS cord-010092-uftc8inx 7693 13 ( ( -LRB- cord-010092-uftc8inx 7693 14 minimum minimum JJ cord-010092-uftc8inx 7693 15 10 10 CD cord-010092-uftc8inx 7693 16 samples sample NNS cord-010092-uftc8inx 7693 17 per per IN cord-010092-uftc8inx 7693 18 test test NN cord-010092-uftc8inx 7693 19 ) ) -RRB- cord-010092-uftc8inx 7693 20 were be VBD cord-010092-uftc8inx 7693 21 randomly randomly RB cord-010092-uftc8inx 7693 22 sorted sort VBN cord-010092-uftc8inx 7693 23 and and CC cord-010092-uftc8inx 7693 24 tested test VBD cord-010092-uftc8inx 7693 25 using use VBG cord-010092-uftc8inx 7693 26 Alinity Alinity NNP cord-010092-uftc8inx 7693 27 S S NNP cord-010092-uftc8inx 7693 28 and and CC cord-010092-uftc8inx 7693 29 Architect Architect NNP cord-010092-uftc8inx 7693 30 i2000SR i2000sr JJ cord-010092-uftc8inx 7693 31 , , , cord-010092-uftc8inx 7693 32 results result NNS cord-010092-uftc8inx 7693 33 were be VBD cord-010092-uftc8inx 7693 34 compared compare VBN cord-010092-uftc8inx 7693 35 using use VBG cord-010092-uftc8inx 7693 36 IBM IBM NNP cord-010092-uftc8inx 7693 37 SPSS SPSS NNP cord-010092-uftc8inx 7693 38 Statistics Statistics NNP cord-010092-uftc8inx 7693 39 â â NNP cord-010092-uftc8inx 7693 40 . . . cord-010092-uftc8inx 7694 1 In in IN cord-010092-uftc8inx 7694 2 order order NN cord-010092-uftc8inx 7694 3 to to TO cord-010092-uftc8inx 7694 4 evaluate evaluate VB cord-010092-uftc8inx 7694 5 repeatability repeatability NN cord-010092-uftc8inx 7694 6 , , , cord-010092-uftc8inx 7694 7 at at IN cord-010092-uftc8inx 7694 8 least least JJS cord-010092-uftc8inx 7694 9 3 3 CD cord-010092-uftc8inx 7694 10 samples sample NNS cord-010092-uftc8inx 7694 11 with with IN cord-010092-uftc8inx 7694 12 different different JJ cord-010092-uftc8inx 7694 13 reactive reactive JJ cord-010092-uftc8inx 7694 14 degrees degree NNS cord-010092-uftc8inx 7694 15 ( ( -LRB- cord-010092-uftc8inx 7694 16 high high JJ cord-010092-uftc8inx 7694 17 , , , cord-010092-uftc8inx 7694 18 intermediate intermediate JJ cord-010092-uftc8inx 7694 19 and and CC cord-010092-uftc8inx 7694 20 low low JJ cord-010092-uftc8inx 7694 21 ) ) -RRB- cord-010092-uftc8inx 7694 22 per per IN cord-010092-uftc8inx 7694 23 test test NN cord-010092-uftc8inx 7694 24 were be VBD cord-010092-uftc8inx 7694 25 repeated repeat VBN cord-010092-uftc8inx 7694 26 , , , cord-010092-uftc8inx 7694 27 using use VBG cord-010092-uftc8inx 7694 28 Alinity Alinity NNP cord-010092-uftc8inx 7694 29 S S NNP cord-010092-uftc8inx 7694 30 , , , cord-010092-uftc8inx 7694 31 an an DT cord-010092-uftc8inx 7694 32 average average NN cord-010092-uftc8inx 7694 33 of of IN cord-010092-uftc8inx 7694 34 10 10 CD cord-010092-uftc8inx 7694 35 times time NNS cord-010092-uftc8inx 7694 36 per per IN cord-010092-uftc8inx 7694 37 sample sample NN cord-010092-uftc8inx 7694 38 and and CC cord-010092-uftc8inx 7694 39 it -PRON- PRP cord-010092-uftc8inx 7694 40 was be VBD cord-010092-uftc8inx 7694 41 determined determine VBN cord-010092-uftc8inx 7694 42 the the DT cord-010092-uftc8inx 7694 43 percentage percentage NN cord-010092-uftc8inx 7694 44 of of IN cord-010092-uftc8inx 7694 45 coefficient coefficient NN cord-010092-uftc8inx 7694 46 of of IN cord-010092-uftc8inx 7694 47 variation variation NN cord-010092-uftc8inx 7694 48 ( ( -LRB- cord-010092-uftc8inx 7694 49 % % NN cord-010092-uftc8inx 7694 50 CV CV NNP cord-010092-uftc8inx 7694 51 ) ) -RRB- cord-010092-uftc8inx 7694 52 . . . cord-010092-uftc8inx 7695 1 Results result NNS cord-010092-uftc8inx 7695 2 : : : cord-010092-uftc8inx 7696 1 A a DT cord-010092-uftc8inx 7696 2 total total NN cord-010092-uftc8inx 7696 3 of of IN cord-010092-uftc8inx 7696 4 85 85 CD cord-010092-uftc8inx 7696 5 samples sample NNS cord-010092-uftc8inx 7696 6 were be VBD cord-010092-uftc8inx 7696 7 tested test VBN cord-010092-uftc8inx 7696 8 ( ( -LRB- cord-010092-uftc8inx 7696 9 10 10 CD cord-010092-uftc8inx 7696 10 for for IN cord-010092-uftc8inx 7696 11 Hbsag Hbsag NNP cord-010092-uftc8inx 7696 12 , , , cord-010092-uftc8inx 7696 13 20 20 CD cord-010092-uftc8inx 7696 14 for for IN cord-010092-uftc8inx 7696 15 Hbsab Hbsab NNP cord-010092-uftc8inx 7696 16 , , , cord-010092-uftc8inx 7696 17 18 18 CD cord-010092-uftc8inx 7696 18 for for IN cord-010092-uftc8inx 7696 19 Hbcab Hbcab NNP cord-010092-uftc8inx 7696 20 , , , cord-010092-uftc8inx 7696 21 14 14 CD cord-010092-uftc8inx 7696 22 for for IN cord-010092-uftc8inx 7696 23 Hbeag Hbeag NNP cord-010092-uftc8inx 7696 24 and and CC cord-010092-uftc8inx 7696 25 23 23 CD cord-010092-uftc8inx 7696 26 for for IN cord-010092-uftc8inx 7696 27 Hbeab Hbeab NNP cord-010092-uftc8inx 7696 28 ) ) -RRB- cord-010092-uftc8inx 7696 29 using use VBG cord-010092-uftc8inx 7696 30 Alinity Alinity NNP cord-010092-uftc8inx 7696 31 S S NNP cord-010092-uftc8inx 7696 32 and and CC cord-010092-uftc8inx 7696 33 Architect Architect NNP cord-010092-uftc8inx 7696 34 i2000SR i2000sr JJ cord-010092-uftc8inx 7696 35 , , , cord-010092-uftc8inx 7696 36 and and CC cord-010092-uftc8inx 7696 37 it -PRON- PRP cord-010092-uftc8inx 7696 38 was be VBD cord-010092-uftc8inx 7696 39 ensured ensure VBN cord-010092-uftc8inx 7696 40 that that IN cord-010092-uftc8inx 7696 41 there there EX cord-010092-uftc8inx 7696 42 were be VBD cord-010092-uftc8inx 7696 43 no no DT cord-010092-uftc8inx 7696 44 statistically statistically RB cord-010092-uftc8inx 7696 45 significant significant JJ cord-010092-uftc8inx 7696 46 differences difference NNS cord-010092-uftc8inx 7696 47 between between IN cord-010092-uftc8inx 7696 48 results result NNS cord-010092-uftc8inx 7696 49 ( ( -LRB- cord-010092-uftc8inx 7696 50 P p NN cord-010092-uftc8inx 7696 51 > > XX cord-010092-uftc8inx 7696 52 .05 .05 NFP cord-010092-uftc8inx 7696 53 ) ) -RRB- cord-010092-uftc8inx 7696 54 . . . cord-010092-uftc8inx 7697 1 Using use VBG cord-010092-uftc8inx 7697 2 3 3 CD cord-010092-uftc8inx 7697 3 samples sample NNS cord-010092-uftc8inx 7697 4 and and CC cord-010092-uftc8inx 7697 5 a a DT cord-010092-uftc8inx 7697 6 total total NN cord-010092-uftc8inx 7697 7 of of IN cord-010092-uftc8inx 7697 8 30 30 CD cord-010092-uftc8inx 7697 9 essays essay NNS cord-010092-uftc8inx 7697 10 we -PRON- PRP cord-010092-uftc8inx 7697 11 found find VBD cord-010092-uftc8inx 7697 12 the the DT cord-010092-uftc8inx 7697 13 % % NN cord-010092-uftc8inx 7697 14 CV CV NNP cord-010092-uftc8inx 7697 15 Hbsag Hbsag NNP cord-010092-uftc8inx 7697 16 ranged range VBD cord-010092-uftc8inx 7697 17 from from IN cord-010092-uftc8inx 7697 18 0 0 CD cord-010092-uftc8inx 7697 19 - - SYM cord-010092-uftc8inx 7697 20 4.375 4.375 CD cord-010092-uftc8inx 7697 21 % % NN cord-010092-uftc8inx 7697 22 . . . cord-010092-uftc8inx 7698 1 3 3 CD cord-010092-uftc8inx 7698 2 samples sample NNS cord-010092-uftc8inx 7698 3 were be VBD cord-010092-uftc8inx 7698 4 tested test VBN cord-010092-uftc8inx 7698 5 for for IN cord-010092-uftc8inx 7698 6 Hbsab Hbsab NNP cord-010092-uftc8inx 7698 7 in in IN cord-010092-uftc8inx 7698 8 a a DT cord-010092-uftc8inx 7698 9 total total NN cord-010092-uftc8inx 7698 10 of of IN cord-010092-uftc8inx 7698 11 33 33 CD cord-010092-uftc8inx 7698 12 essays essay NNS cord-010092-uftc8inx 7698 13 and and CC cord-010092-uftc8inx 7698 14 the the DT cord-010092-uftc8inx 7698 15 % % NN cord-010092-uftc8inx 7698 16 CV cv NN cord-010092-uftc8inx 7698 17 ranged range VBD cord-010092-uftc8inx 7698 18 from from IN cord-010092-uftc8inx 7698 19 0 0 CD cord-010092-uftc8inx 7698 20 - - HYPH cord-010092-uftc8inx 7698 21 5.196 5.196 CD cord-010092-uftc8inx 7698 22 % % NN cord-010092-uftc8inx 7698 23 . . . cord-010092-uftc8inx 7699 1 Hbcab Hbcab NNP cord-010092-uftc8inx 7699 2 was be VBD cord-010092-uftc8inx 7699 3 tested test VBN cord-010092-uftc8inx 7699 4 in in IN cord-010092-uftc8inx 7699 5 3 3 CD cord-010092-uftc8inx 7699 6 samples sample NNS cord-010092-uftc8inx 7699 7 during during IN cord-010092-uftc8inx 7699 8 32 32 CD cord-010092-uftc8inx 7699 9 essays essay NNS cord-010092-uftc8inx 7699 10 and and CC cord-010092-uftc8inx 7699 11 the the DT cord-010092-uftc8inx 7699 12 % % NN cord-010092-uftc8inx 7699 13 CV cv NN cord-010092-uftc8inx 7699 14 ranged range VBD cord-010092-uftc8inx 7699 15 from from IN cord-010092-uftc8inx 7699 16 0 0 CD cord-010092-uftc8inx 7699 17 - - HYPH cord-010092-uftc8inx 7699 18 2.811 2.811 CD cord-010092-uftc8inx 7699 19 % % NN cord-010092-uftc8inx 7699 20 . . . cord-010092-uftc8inx 7700 1 Using use VBG cord-010092-uftc8inx 7700 2 3 3 CD cord-010092-uftc8inx 7700 3 samples sample NNS cord-010092-uftc8inx 7700 4 and and CC cord-010092-uftc8inx 7700 5 a a DT cord-010092-uftc8inx 7700 6 total total NN cord-010092-uftc8inx 7700 7 of of IN cord-010092-uftc8inx 7700 8 28 28 CD cord-010092-uftc8inx 7700 9 essays essay NNS cord-010092-uftc8inx 7700 10 we -PRON- PRP cord-010092-uftc8inx 7700 11 found find VBD cord-010092-uftc8inx 7700 12 the the DT cord-010092-uftc8inx 7700 13 % % NN cord-010092-uftc8inx 7700 14 CV CV NNP cord-010092-uftc8inx 7700 15 Hbeag Hbeag NNP cord-010092-uftc8inx 7700 16 ranged range VBD cord-010092-uftc8inx 7700 17 from from IN cord-010092-uftc8inx 7700 18 4.176 4.176 CD cord-010092-uftc8inx 7700 19 - - SYM cord-010092-uftc8inx 7700 20 5.147 5.147 CD cord-010092-uftc8inx 7700 21 % % NN cord-010092-uftc8inx 7700 22 . . . cord-010092-uftc8inx 7701 1 4 4 CD cord-010092-uftc8inx 7701 2 samples sample NNS cord-010092-uftc8inx 7701 3 were be VBD cord-010092-uftc8inx 7701 4 tested test VBN cord-010092-uftc8inx 7701 5 for for IN cord-010092-uftc8inx 7701 6 Hbeab Hbeab NNP cord-010092-uftc8inx 7701 7 in in IN cord-010092-uftc8inx 7701 8 a a DT cord-010092-uftc8inx 7701 9 total total NN cord-010092-uftc8inx 7701 10 of of IN cord-010092-uftc8inx 7701 11 29 29 CD cord-010092-uftc8inx 7701 12 essays essay NNS cord-010092-uftc8inx 7701 13 and and CC cord-010092-uftc8inx 7701 14 the the DT cord-010092-uftc8inx 7701 15 % % NN cord-010092-uftc8inx 7701 16 CV cv NN cord-010092-uftc8inx 7701 17 ranged range VBD cord-010092-uftc8inx 7701 18 from from IN cord-010092-uftc8inx 7701 19 0 0 CD cord-010092-uftc8inx 7701 20 - - SYM cord-010092-uftc8inx 7701 21 4.444 4.444 CD cord-010092-uftc8inx 7701 22 % % NN cord-010092-uftc8inx 7701 23 . . . cord-010092-uftc8inx 7702 1 Summary Summary NNP cord-010092-uftc8inx 7702 2 / / SYM cord-010092-uftc8inx 7702 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 7702 4 : : : cord-010092-uftc8inx 7703 1 The the DT cord-010092-uftc8inx 7703 2 new new JJ cord-010092-uftc8inx 7703 3 automated automate VBN cord-010092-uftc8inx 7703 4 equipment equipment NN cord-010092-uftc8inx 7703 5 Alinity Alinity NNP cord-010092-uftc8inx 7703 6 S S NNP cord-010092-uftc8inx 7703 7 system system NN cord-010092-uftc8inx 7703 8 demonstrated demonstrate VBD cord-010092-uftc8inx 7703 9 no no DT cord-010092-uftc8inx 7703 10 statistically statistically RB cord-010092-uftc8inx 7703 11 difference difference NN cord-010092-uftc8inx 7703 12 when when WRB cord-010092-uftc8inx 7703 13 compared compare VBN cord-010092-uftc8inx 7703 14 with with IN cord-010092-uftc8inx 7703 15 Architect Architect NNP cord-010092-uftc8inx 7703 16 i2000SR i2000sr JJ cord-010092-uftc8inx 7703 17 and and CC cord-010092-uftc8inx 7703 18 repeatability repeatability NN cord-010092-uftc8inx 7703 19 was be VBD cord-010092-uftc8inx 7703 20 ensured ensure VBN cord-010092-uftc8inx 7703 21 . . . cord-010092-uftc8inx 7704 1 This this DT cord-010092-uftc8inx 7704 2 demonstrates demonstrate VBZ cord-010092-uftc8inx 7704 3 the the DT cord-010092-uftc8inx 7704 4 precision precision NN cord-010092-uftc8inx 7704 5 of of IN cord-010092-uftc8inx 7704 6 results result NNS cord-010092-uftc8inx 7704 7 generated generate VBN cord-010092-uftc8inx 7704 8 by by IN cord-010092-uftc8inx 7704 9 this this DT cord-010092-uftc8inx 7704 10 fully fully RB cord-010092-uftc8inx 7704 11 automated automate VBN cord-010092-uftc8inx 7704 12 blood blood NN cord-010092-uftc8inx 7704 13 screening screening NN cord-010092-uftc8inx 7704 14 analyzer analyzer NN cord-010092-uftc8inx 7704 15 , , , cord-010092-uftc8inx 7704 16 which which WDT cord-010092-uftc8inx 7704 17 helps help VBZ cord-010092-uftc8inx 7704 18 assure assure VB cord-010092-uftc8inx 7704 19 consistent consistent JJ cord-010092-uftc8inx 7704 20 results result NNS cord-010092-uftc8inx 7704 21 for for IN cord-010092-uftc8inx 7704 22 the the DT cord-010092-uftc8inx 7704 23 testing testing NN cord-010092-uftc8inx 7704 24 and and CC cord-010092-uftc8inx 7704 25 retesting retesting NN cord-010092-uftc8inx 7704 26 of of IN cord-010092-uftc8inx 7704 27 blood blood NN cord-010092-uftc8inx 7704 28 specimens specimen NNS cord-010092-uftc8inx 7704 29 for for IN cord-010092-uftc8inx 7704 30 Hbsag Hbsag NNP cord-010092-uftc8inx 7704 31 , , , cord-010092-uftc8inx 7704 32 Hbsab Hbsab NNP cord-010092-uftc8inx 7704 33 , , , cord-010092-uftc8inx 7704 34 Hbcab Hbcab NNP cord-010092-uftc8inx 7704 35 , , , cord-010092-uftc8inx 7704 36 Hbeag Hbeag NNP cord-010092-uftc8inx 7704 37 and and CC cord-010092-uftc8inx 7704 38 Hbeab Hbeab NNP cord-010092-uftc8inx 7704 39 . . . cord-010092-uftc8inx 7705 1 Background background NN cord-010092-uftc8inx 7705 2 : : : cord-010092-uftc8inx 7706 1 Blood blood NN cord-010092-uftc8inx 7706 2 centres centre NNS cord-010092-uftc8inx 7706 3 require require VBP cord-010092-uftc8inx 7706 4 high high JJ cord-010092-uftc8inx 7706 5 throughput throughput NN cord-010092-uftc8inx 7706 6 assays assay NNS cord-010092-uftc8inx 7706 7 with with IN cord-010092-uftc8inx 7706 8 a a DT cord-010092-uftc8inx 7706 9 high high JJ cord-010092-uftc8inx 7706 10 level level NN cord-010092-uftc8inx 7706 11 of of IN cord-010092-uftc8inx 7706 12 reproducibility reproducibility NN cord-010092-uftc8inx 7706 13 to to TO cord-010092-uftc8inx 7706 14 assure assure VB cord-010092-uftc8inx 7706 15 consistent consistent JJ cord-010092-uftc8inx 7706 16 results result NNS cord-010092-uftc8inx 7706 17 and and CC cord-010092-uftc8inx 7706 18 minimize minimize VB cord-010092-uftc8inx 7706 19 unnecessary unnecessary JJ cord-010092-uftc8inx 7706 20 retesting retesting NN cord-010092-uftc8inx 7706 21 of of IN cord-010092-uftc8inx 7706 22 samples sample NNS cord-010092-uftc8inx 7706 23 and and CC cord-010092-uftc8inx 7706 24 deferral deferral NN cord-010092-uftc8inx 7706 25 of of IN cord-010092-uftc8inx 7706 26 donors donor NNS cord-010092-uftc8inx 7706 27 . . . cord-010092-uftc8inx 7707 1 In in IN cord-010092-uftc8inx 7707 2 addition addition NN cord-010092-uftc8inx 7707 3 , , , cord-010092-uftc8inx 7707 4 continued continue VBN cord-010092-uftc8inx 7707 5 economic economic JJ cord-010092-uftc8inx 7707 6 pressures pressure NNS cord-010092-uftc8inx 7707 7 on on IN cord-010092-uftc8inx 7707 8 laboratory laboratory NN cord-010092-uftc8inx 7707 9 operations operation NNS cord-010092-uftc8inx 7707 10 demand demand VBP cord-010092-uftc8inx 7707 11 that that IN cord-010092-uftc8inx 7707 12 assays assay NNS cord-010092-uftc8inx 7707 13 perform perform VBP cord-010092-uftc8inx 7707 14 on on IN cord-010092-uftc8inx 7707 15 platforms platform NNS cord-010092-uftc8inx 7707 16 capable capable JJ cord-010092-uftc8inx 7707 17 of of IN cord-010092-uftc8inx 7707 18 increased increase VBN cord-010092-uftc8inx 7707 19 walk walk NN cord-010092-uftc8inx 7707 20 away away RB cord-010092-uftc8inx 7707 21 time time NN cord-010092-uftc8inx 7707 22 and and CC cord-010092-uftc8inx 7707 23 enhanced enhanced JJ cord-010092-uftc8inx 7707 24 automation automation NN cord-010092-uftc8inx 7707 25 in in IN cord-010092-uftc8inx 7707 26 areas area NNS cord-010092-uftc8inx 7707 27 of of IN cord-010092-uftc8inx 7707 28 reagent reagent NN cord-010092-uftc8inx 7707 29 management management NN cord-010092-uftc8inx 7707 30 , , , cord-010092-uftc8inx 7707 31 retest retest VB cord-010092-uftc8inx 7707 32 options option NNS cord-010092-uftc8inx 7707 33 , , , cord-010092-uftc8inx 7707 34 and and CC cord-010092-uftc8inx 7707 35 commodity commodity NN cord-010092-uftc8inx 7707 36 / / SYM cord-010092-uftc8inx 7707 37 waste waste NN cord-010092-uftc8inx 7707 38 management management NN cord-010092-uftc8inx 7707 39 . . . cord-010092-uftc8inx 7708 1 Aims aim NNS cord-010092-uftc8inx 7708 2 : : : cord-010092-uftc8inx 7708 3 Evaluate evaluate VB cord-010092-uftc8inx 7708 4 the the DT cord-010092-uftc8inx 7708 5 reproducibility reproducibility NN cord-010092-uftc8inx 7708 6 of of IN cord-010092-uftc8inx 7708 7 HIVag HIVag NNP cord-010092-uftc8inx 7708 8 / / SYM cord-010092-uftc8inx 7708 9 ab ab NN cord-010092-uftc8inx 7708 10 , , , cord-010092-uftc8inx 7708 11 Syphilis Syphilis NNP cord-010092-uftc8inx 7708 12 and and CC cord-010092-uftc8inx 7708 13 HTLV HTLV NNP cord-010092-uftc8inx 7708 14 I I NNP cord-010092-uftc8inx 7708 15 / / SYM cord-010092-uftc8inx 7708 16 II II NNP cord-010092-uftc8inx 7708 17 essays essay NNS cord-010092-uftc8inx 7708 18 using use VBG cord-010092-uftc8inx 7708 19 Abbott Abbott NNP cord-010092-uftc8inx 7708 20 Alinity Alinity NNP cord-010092-uftc8inx 7708 21 S S NNP cord-010092-uftc8inx 7708 22 when when WRB cord-010092-uftc8inx 7708 23 compared compare VBN cord-010092-uftc8inx 7708 24 to to IN cord-010092-uftc8inx 7708 25 Architect Architect NNP cord-010092-uftc8inx 7708 26 i2000SR i2000sr JJ cord-010092-uftc8inx 7708 27 . . . cord-010092-uftc8inx 7709 1 Determine determine VB cord-010092-uftc8inx 7709 2 repeatability repeatability NN cord-010092-uftc8inx 7709 3 of of IN cord-010092-uftc8inx 7709 4 these these DT cord-010092-uftc8inx 7709 5 tests test NNS cord-010092-uftc8inx 7709 6 in in IN cord-010092-uftc8inx 7709 7 Alinity Alinity NNP cord-010092-uftc8inx 7709 8 S S NNP cord-010092-uftc8inx 7709 9 essays essay NNS cord-010092-uftc8inx 7709 10 . . . cord-010092-uftc8inx 7710 1 Methods method NNS cord-010092-uftc8inx 7710 2 : : : cord-010092-uftc8inx 7710 3 During during IN cord-010092-uftc8inx 7710 4 2 2 CD cord-010092-uftc8inx 7710 5 months month NNS cord-010092-uftc8inx 7710 6 a a DT cord-010092-uftc8inx 7710 7 study study NN cord-010092-uftc8inx 7710 8 was be VBD cord-010092-uftc8inx 7710 9 conducted conduct VBN cord-010092-uftc8inx 7710 10 where where WRB cord-010092-uftc8inx 7710 11 several several JJ cord-010092-uftc8inx 7710 12 samples sample NNS cord-010092-uftc8inx 7710 13 ( ( -LRB- cord-010092-uftc8inx 7710 14 minimum minimum JJ cord-010092-uftc8inx 7710 15 10 10 CD cord-010092-uftc8inx 7710 16 samples sample NNS cord-010092-uftc8inx 7710 17 per per IN cord-010092-uftc8inx 7710 18 test test NN cord-010092-uftc8inx 7710 19 ) ) -RRB- cord-010092-uftc8inx 7710 20 were be VBD cord-010092-uftc8inx 7710 21 randomly randomly RB cord-010092-uftc8inx 7710 22 sorted sort VBN cord-010092-uftc8inx 7710 23 and and CC cord-010092-uftc8inx 7710 24 tested test VBD cord-010092-uftc8inx 7710 25 using use VBG cord-010092-uftc8inx 7710 26 Alinity Alinity NNP cord-010092-uftc8inx 7710 27 S S NNP cord-010092-uftc8inx 7710 28 and and CC cord-010092-uftc8inx 7710 29 Architect Architect NNP cord-010092-uftc8inx 7710 30 i2000SR i2000sr JJ cord-010092-uftc8inx 7710 31 , , , cord-010092-uftc8inx 7710 32 results result NNS cord-010092-uftc8inx 7710 33 were be VBD cord-010092-uftc8inx 7710 34 compared compare VBN cord-010092-uftc8inx 7710 35 using use VBG cord-010092-uftc8inx 7710 36 IBM IBM NNP cord-010092-uftc8inx 7710 37 SPSS SPSS NNP cord-010092-uftc8inx 7710 38 Statistics Statistics NNP cord-010092-uftc8inx 7710 39 â â NNP cord-010092-uftc8inx 7710 40 . . . cord-010092-uftc8inx 7711 1 In in IN cord-010092-uftc8inx 7711 2 order order NN cord-010092-uftc8inx 7711 3 to to TO cord-010092-uftc8inx 7711 4 evaluate evaluate VB cord-010092-uftc8inx 7711 5 repeatability repeatability NN cord-010092-uftc8inx 7711 6 , , , cord-010092-uftc8inx 7711 7 at at IN cord-010092-uftc8inx 7711 8 least least JJS cord-010092-uftc8inx 7711 9 3 3 CD cord-010092-uftc8inx 7711 10 samples sample NNS cord-010092-uftc8inx 7711 11 with with IN cord-010092-uftc8inx 7711 12 different different JJ cord-010092-uftc8inx 7711 13 reactive reactive JJ cord-010092-uftc8inx 7711 14 degrees degree NNS cord-010092-uftc8inx 7711 15 ( ( -LRB- cord-010092-uftc8inx 7711 16 high high JJ cord-010092-uftc8inx 7711 17 , , , cord-010092-uftc8inx 7711 18 intermediate intermediate JJ cord-010092-uftc8inx 7711 19 and and CC cord-010092-uftc8inx 7711 20 low low JJ cord-010092-uftc8inx 7711 21 ) ) -RRB- cord-010092-uftc8inx 7711 22 per per IN cord-010092-uftc8inx 7711 23 test test NN cord-010092-uftc8inx 7711 24 were be VBD cord-010092-uftc8inx 7711 25 repeated repeat VBN cord-010092-uftc8inx 7711 26 , , , cord-010092-uftc8inx 7711 27 using use VBG cord-010092-uftc8inx 7711 28 Alinity Alinity NNP cord-010092-uftc8inx 7711 29 S S NNP cord-010092-uftc8inx 7711 30 , , , cord-010092-uftc8inx 7711 31 an an DT cord-010092-uftc8inx 7711 32 average average NN cord-010092-uftc8inx 7711 33 of of IN cord-010092-uftc8inx 7711 34 10 10 CD cord-010092-uftc8inx 7711 35 times time NNS cord-010092-uftc8inx 7711 36 per per IN cord-010092-uftc8inx 7711 37 sample sample NN cord-010092-uftc8inx 7711 38 and and CC cord-010092-uftc8inx 7711 39 it -PRON- PRP cord-010092-uftc8inx 7711 40 was be VBD cord-010092-uftc8inx 7711 41 determined determine VBN cord-010092-uftc8inx 7711 42 the the DT cord-010092-uftc8inx 7711 43 percentage percentage NN cord-010092-uftc8inx 7711 44 of of IN cord-010092-uftc8inx 7711 45 coefficient coefficient NN cord-010092-uftc8inx 7711 46 of of IN cord-010092-uftc8inx 7711 47 variation variation NN cord-010092-uftc8inx 7711 48 ( ( -LRB- cord-010092-uftc8inx 7711 49 % % NN cord-010092-uftc8inx 7711 50 CV CV NNP cord-010092-uftc8inx 7711 51 ) ) -RRB- cord-010092-uftc8inx 7711 52 . . . cord-010092-uftc8inx 7712 1 Results result NNS cord-010092-uftc8inx 7712 2 : : : cord-010092-uftc8inx 7713 1 A a DT cord-010092-uftc8inx 7713 2 total total NN cord-010092-uftc8inx 7713 3 of of IN cord-010092-uftc8inx 7713 4 38 38 CD cord-010092-uftc8inx 7713 5 samples sample NNS cord-010092-uftc8inx 7713 6 were be VBD cord-010092-uftc8inx 7713 7 tested test VBN cord-010092-uftc8inx 7713 8 ( ( -LRB- cord-010092-uftc8inx 7713 9 12 12 CD cord-010092-uftc8inx 7713 10 for for IN cord-010092-uftc8inx 7713 11 HIVag HIVag NNP cord-010092-uftc8inx 7713 12 / / SYM cord-010092-uftc8inx 7713 13 ab ab NNP cord-010092-uftc8inx 7713 14 , , , cord-010092-uftc8inx 7713 15 14 14 CD cord-010092-uftc8inx 7713 16 for for IN cord-010092-uftc8inx 7713 17 Syphilis Syphilis NNP cord-010092-uftc8inx 7713 18 and and CC cord-010092-uftc8inx 7713 19 12 12 CD cord-010092-uftc8inx 7713 20 for for IN cord-010092-uftc8inx 7713 21 HTLV HTLV NNP cord-010092-uftc8inx 7713 22 I I NNP cord-010092-uftc8inx 7713 23 / / SYM cord-010092-uftc8inx 7713 24 II II NNP cord-010092-uftc8inx 7713 25 ) ) -RRB- cord-010092-uftc8inx 7713 26 using use VBG cord-010092-uftc8inx 7713 27 Alinity Alinity NNP cord-010092-uftc8inx 7713 28 S S NNP cord-010092-uftc8inx 7713 29 and and CC cord-010092-uftc8inx 7713 30 Architect Architect NNP cord-010092-uftc8inx 7713 31 i2000SR i2000sr JJ cord-010092-uftc8inx 7713 32 , , , cord-010092-uftc8inx 7713 33 and and CC cord-010092-uftc8inx 7713 34 it -PRON- PRP cord-010092-uftc8inx 7713 35 was be VBD cord-010092-uftc8inx 7713 36 ensured ensure VBN cord-010092-uftc8inx 7713 37 that that IN cord-010092-uftc8inx 7713 38 there there EX cord-010092-uftc8inx 7713 39 were be VBD cord-010092-uftc8inx 7713 40 no no DT cord-010092-uftc8inx 7713 41 statistically statistically RB cord-010092-uftc8inx 7713 42 significant significant JJ cord-010092-uftc8inx 7713 43 differences difference NNS cord-010092-uftc8inx 7713 44 between between IN cord-010092-uftc8inx 7713 45 results result NNS cord-010092-uftc8inx 7713 46 ( ( -LRB- cord-010092-uftc8inx 7713 47 P p NN cord-010092-uftc8inx 7713 48 > > XX cord-010092-uftc8inx 7713 49 .05 .05 NFP cord-010092-uftc8inx 7713 50 ) ) -RRB- cord-010092-uftc8inx 7713 51 . . . cord-010092-uftc8inx 7714 1 Using use VBG cord-010092-uftc8inx 7714 2 3 3 CD cord-010092-uftc8inx 7714 3 samples sample NNS cord-010092-uftc8inx 7714 4 and and CC cord-010092-uftc8inx 7714 5 a a DT cord-010092-uftc8inx 7714 6 total total NN cord-010092-uftc8inx 7714 7 of of IN cord-010092-uftc8inx 7714 8 31 31 CD cord-010092-uftc8inx 7714 9 essays essay NNS cord-010092-uftc8inx 7714 10 we -PRON- PRP cord-010092-uftc8inx 7714 11 found find VBD cord-010092-uftc8inx 7714 12 the the DT cord-010092-uftc8inx 7714 13 % % NN cord-010092-uftc8inx 7714 14 CV CV NNP cord-010092-uftc8inx 7714 15 HIVag HIVag NNP cord-010092-uftc8inx 7714 16 / / SYM cord-010092-uftc8inx 7714 17 ab ab NNP cord-010092-uftc8inx 7714 18 ranged range VBD cord-010092-uftc8inx 7714 19 from from IN cord-010092-uftc8inx 7714 20 0 0 CD cord-010092-uftc8inx 7714 21 to to IN cord-010092-uftc8inx 7714 22 3.05 3.05 CD cord-010092-uftc8inx 7714 23 % % NN cord-010092-uftc8inx 7714 24 . . . cord-010092-uftc8inx 7715 1 2 2 CD cord-010092-uftc8inx 7715 2 samples sample NNS cord-010092-uftc8inx 7715 3 were be VBD cord-010092-uftc8inx 7715 4 tested test VBN cord-010092-uftc8inx 7715 5 for for IN cord-010092-uftc8inx 7715 6 Syphilis Syphilis NNP cord-010092-uftc8inx 7715 7 in in IN cord-010092-uftc8inx 7715 8 a a DT cord-010092-uftc8inx 7715 9 total total NN cord-010092-uftc8inx 7715 10 of of IN cord-010092-uftc8inx 7715 11 22 22 CD cord-010092-uftc8inx 7715 12 essays essay NNS cord-010092-uftc8inx 7715 13 and and CC cord-010092-uftc8inx 7715 14 the the DT cord-010092-uftc8inx 7715 15 % % NN cord-010092-uftc8inx 7715 16 CV cv NN cord-010092-uftc8inx 7715 17 ranged range VBD cord-010092-uftc8inx 7715 18 from from IN cord-010092-uftc8inx 7715 19 0 0 CD cord-010092-uftc8inx 7715 20 to to IN cord-010092-uftc8inx 7715 21 1.481 1.481 CD cord-010092-uftc8inx 7715 22 % % NN cord-010092-uftc8inx 7715 23 . . . cord-010092-uftc8inx 7716 1 HTLV HTLV NNP cord-010092-uftc8inx 7717 1 I I NNP cord-010092-uftc8inx 7717 2 / / SYM cord-010092-uftc8inx 7717 3 II II NNP cord-010092-uftc8inx 7717 4 was be VBD cord-010092-uftc8inx 7717 5 tested test VBN cord-010092-uftc8inx 7717 6 in in IN cord-010092-uftc8inx 7717 7 3 3 CD cord-010092-uftc8inx 7717 8 samples sample NNS cord-010092-uftc8inx 7717 9 during during IN cord-010092-uftc8inx 7717 10 28 28 CD cord-010092-uftc8inx 7717 11 essays essay NNS cord-010092-uftc8inx 7717 12 and and CC cord-010092-uftc8inx 7717 13 the the DT cord-010092-uftc8inx 7717 14 % % NN cord-010092-uftc8inx 7717 15 CV cv NN cord-010092-uftc8inx 7717 16 ranged range VBD cord-010092-uftc8inx 7717 17 from from IN cord-010092-uftc8inx 7717 18 3.342 3.342 CD cord-010092-uftc8inx 7717 19 to to IN cord-010092-uftc8inx 7717 20 7.5 7.5 CD cord-010092-uftc8inx 7717 21 % % NN cord-010092-uftc8inx 7717 22 . . . cord-010092-uftc8inx 7718 1 Summary Summary NNP cord-010092-uftc8inx 7718 2 / / SYM cord-010092-uftc8inx 7718 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 7718 4 : : : cord-010092-uftc8inx 7719 1 The the DT cord-010092-uftc8inx 7719 2 new new JJ cord-010092-uftc8inx 7719 3 automated automate VBN cord-010092-uftc8inx 7719 4 equipment equipment NN cord-010092-uftc8inx 7719 5 Alinity Alinity NNP cord-010092-uftc8inx 7719 6 S S NNP cord-010092-uftc8inx 7719 7 system system NN cord-010092-uftc8inx 7719 8 demonstrated demonstrate VBD cord-010092-uftc8inx 7719 9 no no DT cord-010092-uftc8inx 7719 10 statistically statistically RB cord-010092-uftc8inx 7719 11 difference difference NN cord-010092-uftc8inx 7719 12 when when WRB cord-010092-uftc8inx 7719 13 compared compare VBN cord-010092-uftc8inx 7719 14 with with IN cord-010092-uftc8inx 7719 15 Architect Architect NNP cord-010092-uftc8inx 7719 16 i2000SR i2000sr JJ cord-010092-uftc8inx 7719 17 and and CC cord-010092-uftc8inx 7719 18 repeatability repeatability NN cord-010092-uftc8inx 7719 19 was be VBD cord-010092-uftc8inx 7719 20 ensured ensure VBN cord-010092-uftc8inx 7719 21 . . . cord-010092-uftc8inx 7720 1 This this DT cord-010092-uftc8inx 7720 2 demonstrates demonstrate VBZ cord-010092-uftc8inx 7720 3 the the DT cord-010092-uftc8inx 7720 4 precision precision NN cord-010092-uftc8inx 7720 5 of of IN cord-010092-uftc8inx 7720 6 results result NNS cord-010092-uftc8inx 7720 7 generated generate VBN cord-010092-uftc8inx 7720 8 by by IN cord-010092-uftc8inx 7720 9 this this DT cord-010092-uftc8inx 7720 10 fully fully RB cord-010092-uftc8inx 7720 11 automated automate VBN cord-010092-uftc8inx 7720 12 blood blood NN cord-010092-uftc8inx 7720 13 screening screening NN cord-010092-uftc8inx 7720 14 analyzer analyzer NN cord-010092-uftc8inx 7720 15 , , , cord-010092-uftc8inx 7720 16 which which WDT cord-010092-uftc8inx 7720 17 helps help VBZ cord-010092-uftc8inx 7720 18 assure assure VB cord-010092-uftc8inx 7720 19 consistent consistent JJ cord-010092-uftc8inx 7720 20 results result NNS cord-010092-uftc8inx 7720 21 for for IN cord-010092-uftc8inx 7720 22 the the DT cord-010092-uftc8inx 7720 23 testing testing NN cord-010092-uftc8inx 7720 24 and and CC cord-010092-uftc8inx 7720 25 retesting retesting NN cord-010092-uftc8inx 7720 26 of of IN cord-010092-uftc8inx 7720 27 blood blood NN cord-010092-uftc8inx 7720 28 specimens specimen NNS cord-010092-uftc8inx 7720 29 for for IN cord-010092-uftc8inx 7720 30 HIVag HIVag NNP cord-010092-uftc8inx 7720 31 / / SYM cord-010092-uftc8inx 7720 32 ab ab NN cord-010092-uftc8inx 7720 33 , , , cord-010092-uftc8inx 7720 34 Syphilis Syphilis NNP cord-010092-uftc8inx 7720 35 and and CC cord-010092-uftc8inx 7720 36 HTLV HTLV NNP cord-010092-uftc8inx 7720 37 I I NNP cord-010092-uftc8inx 7720 38 / / SYM cord-010092-uftc8inx 7720 39 II II NNP cord-010092-uftc8inx 7720 40 . . NNP cord-010092-uftc8inx 7720 41 , , , cord-010092-uftc8inx 7720 42 Human Human NNP cord-010092-uftc8inx 7720 43 Immunodeficiency Immunodeficiency NNP cord-010092-uftc8inx 7720 44 ( ( -LRB- cord-010092-uftc8inx 7720 45 HIV HIV NNP cord-010092-uftc8inx 7720 46 ) ) -RRB- cord-010092-uftc8inx 7720 47 and and CC cord-010092-uftc8inx 7720 48 Hepatitis Hepatitis NNP cord-010092-uftc8inx 7720 49 C C NNP cord-010092-uftc8inx 7720 50 ( ( -LRB- cord-010092-uftc8inx 7720 51 HCV HCV NNP cord-010092-uftc8inx 7720 52 ) ) -RRB- cord-010092-uftc8inx 7720 53 viruses virus NNS cord-010092-uftc8inx 7720 54 ' ' POS cord-010092-uftc8inx 7720 55 infection infection NN cord-010092-uftc8inx 7720 56 in in IN cord-010092-uftc8inx 7720 57 blood blood NN cord-010092-uftc8inx 7720 58 donors donor NNS cord-010092-uftc8inx 7720 59 were be VBD cord-010092-uftc8inx 7720 60 1.27 1.27 CD cord-010092-uftc8inx 7720 61 % % NN cord-010092-uftc8inx 7720 62 , , , cord-010092-uftc8inx 7720 63 0.20 0.20 CD cord-010092-uftc8inx 7720 64 % % NN cord-010092-uftc8inx 7720 65 and and CC cord-010092-uftc8inx 7720 66 0.50 0.50 CD cord-010092-uftc8inx 7720 67 % % NN cord-010092-uftc8inx 7720 68 respectively respectively RB cord-010092-uftc8inx 7720 69 . . . cord-010092-uftc8inx 7721 1 Consecutive consecutive JJ cord-010092-uftc8inx 7721 2 positive positive JJ cord-010092-uftc8inx 7721 3 results result NNS cord-010092-uftc8inx 7721 4 for for IN cord-010092-uftc8inx 7721 5 HBV HBV NNP cord-010092-uftc8inx 7721 6 were be VBD cord-010092-uftc8inx 7721 7 9.20 9.20 CD cord-010092-uftc8inx 7721 8 % % NN cord-010092-uftc8inx 7721 9 ( ( -LRB- cord-010092-uftc8inx 7721 10 63/685 63/685 CD cord-010092-uftc8inx 7721 11 ) ) -RRB- cord-010092-uftc8inx 7721 12 , , , cord-010092-uftc8inx 7721 13 for for IN cord-010092-uftc8inx 7721 14 HCV HCV NNP cord-010092-uftc8inx 7721 15 were be VBD cord-010092-uftc8inx 7721 16 6.0 6.0 CD cord-010092-uftc8inx 7721 17 % % NN cord-010092-uftc8inx 7721 18 ( ( -LRB- cord-010092-uftc8inx 7721 19 16/266 16/266 CD cord-010092-uftc8inx 7721 20 ) ) -RRB- cord-010092-uftc8inx 7721 21 and and CC cord-010092-uftc8inx 7721 22 nil nil NN cord-010092-uftc8inx 7721 23 for for IN cord-010092-uftc8inx 7721 24 HIV HIV NNP cord-010092-uftc8inx 7721 25 . . . cord-010092-uftc8inx 7722 1 There there EX cord-010092-uftc8inx 7722 2 was be VBD cord-010092-uftc8inx 7722 3 no no DT cord-010092-uftc8inx 7722 4 sample sample NN cord-010092-uftc8inx 7722 5 carry carry NN cord-010092-uftc8inx 7722 6 over over RP cord-010092-uftc8inx 7722 7 in in IN cord-010092-uftc8inx 7722 8 this this DT cord-010092-uftc8inx 7722 9 . . . cord-010092-uftc8inx 7723 1 Out out IN cord-010092-uftc8inx 7723 2 of of IN cord-010092-uftc8inx 7723 3 79 79 CD cord-010092-uftc8inx 7723 4 consecutive consecutive JJ cord-010092-uftc8inx 7723 5 reactive reactive JJ cord-010092-uftc8inx 7723 6 donors donor NNS cord-010092-uftc8inx 7723 7 69 69 CD cord-010092-uftc8inx 7723 8 were be VBD cord-010092-uftc8inx 7723 9 donated donate VBN cord-010092-uftc8inx 7723 10 for for IN cord-010092-uftc8inx 7723 11 same same JJ cord-010092-uftc8inx 7723 12 patients patient NNS cord-010092-uftc8inx 7723 13 and and CC cord-010092-uftc8inx 7723 14 32 32 CD cord-010092-uftc8inx 7723 15 were be VBD cord-010092-uftc8inx 7723 16 related relate VBN cord-010092-uftc8inx 7723 17 with with IN cord-010092-uftc8inx 7723 18 infected infected JJ cord-010092-uftc8inx 7723 19 patient patient NN cord-010092-uftc8inx 7723 20 which which WDT cord-010092-uftc8inx 7723 21 were be VBD cord-010092-uftc8inx 7723 22 statistically statistically RB cord-010092-uftc8inx 7723 23 significant significant JJ cord-010092-uftc8inx 7723 24 ( ( -LRB- cord-010092-uftc8inx 7723 25 P p NN cord-010092-uftc8inx 7723 26 < < XX cord-010092-uftc8inx 7723 27 0.0001 0.0001 CD cord-010092-uftc8inx 7723 28 ) ) -RRB- cord-010092-uftc8inx 7723 29 . . . cord-010092-uftc8inx 7724 1 Summary Summary NNP cord-010092-uftc8inx 7724 2 / / SYM cord-010092-uftc8inx 7724 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 7724 4 : : : cord-010092-uftc8inx 7725 1 Among among IN cord-010092-uftc8inx 7725 2 all all DT cord-010092-uftc8inx 7725 3 TTI TTI NNP cord-010092-uftc8inx 7725 4 reactive reactive JJ cord-010092-uftc8inx 7725 5 donors donor NNS cord-010092-uftc8inx 7725 6 7.4 7.4 CD cord-010092-uftc8inx 7725 7 % % NN cord-010092-uftc8inx 7725 8 ( ( -LRB- cord-010092-uftc8inx 7725 9 79/1061 79/1061 LS cord-010092-uftc8inx 7725 10 ) ) -RRB- cord-010092-uftc8inx 7725 11 were be VBD cord-010092-uftc8inx 7725 12 consecutive consecutive JJ cord-010092-uftc8inx 7725 13 reactive reactive JJ cord-010092-uftc8inx 7725 14 . . . cord-010092-uftc8inx 7726 1 The the DT cord-010092-uftc8inx 7726 2 reason reason NN cord-010092-uftc8inx 7726 3 for for IN cord-010092-uftc8inx 7726 4 the the DT cord-010092-uftc8inx 7726 5 same same JJ cord-010092-uftc8inx 7726 6 may may MD cord-010092-uftc8inx 7726 7 be be VB cord-010092-uftc8inx 7726 8 process process NN cord-010092-uftc8inx 7726 9 related relate VBN cord-010092-uftc8inx 7726 10 like like IN cord-010092-uftc8inx 7726 11 sample sample NN cord-010092-uftc8inx 7726 12 carry carry NN cord-010092-uftc8inx 7726 13 over over RP cord-010092-uftc8inx 7726 14 or or CC cord-010092-uftc8inx 7726 15 reagent reagent NN cord-010092-uftc8inx 7726 16 carry carry NN cord-010092-uftc8inx 7726 17 over over RP cord-010092-uftc8inx 7726 18 or or CC cord-010092-uftc8inx 7726 19 donor donor NN cord-010092-uftc8inx 7726 20 related relate VBN cord-010092-uftc8inx 7726 21 . . . cord-010092-uftc8inx 7727 1 Donor donor NN cord-010092-uftc8inx 7727 2 related related JJ cord-010092-uftc8inx 7727 3 reasons reason NNS cord-010092-uftc8inx 7727 4 may may MD cord-010092-uftc8inx 7727 5 be be VB cord-010092-uftc8inx 7727 6 , , , cord-010092-uftc8inx 7727 7 one one CD cord-010092-uftc8inx 7727 8 of of IN cord-010092-uftc8inx 7727 9 the the DT cord-010092-uftc8inx 7727 10 close close JJ cord-010092-uftc8inx 7727 11 relative relative NN cord-010092-uftc8inx 7727 12 is be VBZ cord-010092-uftc8inx 7727 13 reactive reactive JJ cord-010092-uftc8inx 7727 14 for for IN cord-010092-uftc8inx 7727 15 virus virus NN cord-010092-uftc8inx 7727 16 and and CC cord-010092-uftc8inx 7727 17 that that DT cord-010092-uftc8inx 7727 18 is be VBZ cord-010092-uftc8inx 7727 19 transmitted transmit VBN cord-010092-uftc8inx 7727 20 to to IN cord-010092-uftc8inx 7727 21 other other JJ cord-010092-uftc8inx 7727 22 family family NN cord-010092-uftc8inx 7727 23 members member NNS cord-010092-uftc8inx 7727 24 . . . cord-010092-uftc8inx 7728 1 In in IN cord-010092-uftc8inx 7728 2 our -PRON- PRP$ cord-010092-uftc8inx 7728 3 study study NN cord-010092-uftc8inx 7728 4 32 32 CD cord-010092-uftc8inx 7728 5 reactive reactive JJ cord-010092-uftc8inx 7728 6 donors donor NNS cord-010092-uftc8inx 7728 7 either either CC cord-010092-uftc8inx 7728 8 had have VBD cord-010092-uftc8inx 7728 9 close close JJ cord-010092-uftc8inx 7728 10 contacts contact NNS cord-010092-uftc8inx 7728 11 with with IN cord-010092-uftc8inx 7728 12 persons person NNS cord-010092-uftc8inx 7728 13 with with IN cord-010092-uftc8inx 7728 14 history history NN cord-010092-uftc8inx 7728 15 of of IN cord-010092-uftc8inx 7728 16 infective infective JJ cord-010092-uftc8inx 7728 17 disease disease NN cord-010092-uftc8inx 7728 18 or or CC cord-010092-uftc8inx 7728 19 were be VBD cord-010092-uftc8inx 7728 20 their -PRON- PRP$ cord-010092-uftc8inx 7728 21 first first JJ cord-010092-uftc8inx 7728 22 degree degree NN cord-010092-uftc8inx 7728 23 family family NN cord-010092-uftc8inx 7728 24 relatives relative NNS cord-010092-uftc8inx 7728 25 . . . cord-010092-uftc8inx 7729 1 These these DT cord-010092-uftc8inx 7729 2 findings finding NNS cord-010092-uftc8inx 7729 3 were be VBD cord-010092-uftc8inx 7729 4 found find VBN cord-010092-uftc8inx 7729 5 statistically statistically RB cord-010092-uftc8inx 7729 6 significant significant JJ cord-010092-uftc8inx 7729 7 ( ( -LRB- cord-010092-uftc8inx 7729 8 P p NN cord-010092-uftc8inx 7729 9 < < XX cord-010092-uftc8inx 7729 10 0.0001 0.0001 CD cord-010092-uftc8inx 7729 11 ) ) -RRB- cord-010092-uftc8inx 7729 12 . . . cord-010092-uftc8inx 7730 1 This this DT cord-010092-uftc8inx 7730 2 study study NN cord-010092-uftc8inx 7730 3 recommends recommend VBZ cord-010092-uftc8inx 7730 4 that that IN cord-010092-uftc8inx 7730 5 in in IN cord-010092-uftc8inx 7730 6 analysis analysis NN cord-010092-uftc8inx 7730 7 of of IN cord-010092-uftc8inx 7730 8 consecutive consecutive JJ cord-010092-uftc8inx 7730 9 positive positive JJ cord-010092-uftc8inx 7730 10 results result NNS cord-010092-uftc8inx 7730 11 in in IN cord-010092-uftc8inx 7730 12 ELISA ELISA NNP cord-010092-uftc8inx 7730 13 along along IN cord-010092-uftc8inx 7730 14 with with IN cord-010092-uftc8inx 7730 15 looking look VBG cord-010092-uftc8inx 7730 16 for for IN cord-010092-uftc8inx 7730 17 procedure procedure NN cord-010092-uftc8inx 7730 18 / / SYM cord-010092-uftc8inx 7730 19 sample sample NN cord-010092-uftc8inx 7730 20 error error NN cord-010092-uftc8inx 7730 21 , , , cord-010092-uftc8inx 7730 22 there there EX cord-010092-uftc8inx 7730 23 is be VBZ cord-010092-uftc8inx 7730 24 also also RB cord-010092-uftc8inx 7730 25 a a DT cord-010092-uftc8inx 7730 26 need need NN cord-010092-uftc8inx 7730 27 to to TO cord-010092-uftc8inx 7730 28 take take VB cord-010092-uftc8inx 7730 29 retrospective retrospective JJ cord-010092-uftc8inx 7730 30 history history NN cord-010092-uftc8inx 7730 31 of of IN cord-010092-uftc8inx 7730 32 donors donor NNS cord-010092-uftc8inx 7730 33 for for IN cord-010092-uftc8inx 7730 34 close close JJ cord-010092-uftc8inx 7730 35 contact contact NN cord-010092-uftc8inx 7730 36 with with IN cord-010092-uftc8inx 7730 37 infected infected JJ cord-010092-uftc8inx 7730 38 patient patient NN cord-010092-uftc8inx 7730 39 . . . cord-010092-uftc8inx 7731 1 Background background NN cord-010092-uftc8inx 7731 2 : : : cord-010092-uftc8inx 7732 1 Screening screen VBG cord-010092-uftc8inx 7732 2 for for IN cord-010092-uftc8inx 7732 3 transfusion transfusion NN cord-010092-uftc8inx 7732 4 - - HYPH cord-010092-uftc8inx 7732 5 transmitted transmit VBN cord-010092-uftc8inx 7732 6 infections infection NNS cord-010092-uftc8inx 7732 7 ( ( -LRB- cord-010092-uftc8inx 7732 8 TTIs tti NNS cord-010092-uftc8inx 7732 9 ) ) -RRB- cord-010092-uftc8inx 7732 10 is be VBZ cord-010092-uftc8inx 7732 11 critical critical JJ cord-010092-uftc8inx 7732 12 in in IN cord-010092-uftc8inx 7732 13 ensuring ensure VBG cord-010092-uftc8inx 7732 14 safety safety NN cord-010092-uftc8inx 7732 15 of of IN cord-010092-uftc8inx 7732 16 blood blood NN cord-010092-uftc8inx 7732 17 products product NNS cord-010092-uftc8inx 7732 18 . . . cord-010092-uftc8inx 7733 1 Transmission transmission NN cord-010092-uftc8inx 7733 2 of of IN cord-010092-uftc8inx 7733 3 infections infection NNS cord-010092-uftc8inx 7733 4 through through IN cord-010092-uftc8inx 7733 5 transfusion transfusion NN cord-010092-uftc8inx 7733 6 remains remain VBZ cord-010092-uftc8inx 7733 7 a a DT cord-010092-uftc8inx 7733 8 major major JJ cord-010092-uftc8inx 7733 9 source source NN cord-010092-uftc8inx 7733 10 of of IN cord-010092-uftc8inx 7733 11 viral viral JJ cord-010092-uftc8inx 7733 12 hepatitis hepatitis NN cord-010092-uftc8inx 7733 13 especially especially RB cord-010092-uftc8inx 7733 14 HBV HBV NNP cord-010092-uftc8inx 7733 15 and and CC cord-010092-uftc8inx 7733 16 HCV HCV NNP cord-010092-uftc8inx 7733 17 . . . cord-010092-uftc8inx 7734 1 The the DT cord-010092-uftc8inx 7734 2 effectiveness effectiveness NN cord-010092-uftc8inx 7734 3 of of IN cord-010092-uftc8inx 7734 4 rapid rapid JJ cord-010092-uftc8inx 7734 5 immunochromatographic immunochromatographic JJ cord-010092-uftc8inx 7734 6 test test NN cord-010092-uftc8inx 7734 7 ( ( -LRB- cord-010092-uftc8inx 7734 8 ICT ICT NNP cord-010092-uftc8inx 7734 9 ) ) -RRB- cord-010092-uftc8inx 7734 10 devices device NNS cord-010092-uftc8inx 7734 11 for for IN cord-010092-uftc8inx 7734 12 screening screening NN cord-010092-uftc8inx 7734 13 of of IN cord-010092-uftc8inx 7734 14 blood blood NN cord-010092-uftc8inx 7734 15 is be VBZ cord-010092-uftc8inx 7734 16 a a DT cord-010092-uftc8inx 7734 17 concern concern NN cord-010092-uftc8inx 7734 18 and and CC cord-010092-uftc8inx 7734 19 needs need VBZ cord-010092-uftc8inx 7734 20 validation validation NN cord-010092-uftc8inx 7734 21 through through IN cord-010092-uftc8inx 7734 22 advanced advanced JJ cord-010092-uftc8inx 7734 23 methods method NNS cord-010092-uftc8inx 7734 24 like like IN cord-010092-uftc8inx 7734 25 Chemiluminescence Chemiluminescence NNP cord-010092-uftc8inx 7734 26 Immunoassay Immunoassay NNP cord-010092-uftc8inx 7734 27 ( ( -LRB- cord-010092-uftc8inx 7734 28 CLIA CLIA NNP cord-010092-uftc8inx 7734 29 ) ) -RRB- cord-010092-uftc8inx 7734 30 and and CC cord-010092-uftc8inx 7734 31 Polymerase Polymerase NNP cord-010092-uftc8inx 7734 32 Chain Chain NNP cord-010092-uftc8inx 7734 33 Reaction reaction NN cord-010092-uftc8inx 7734 34 ( ( -LRB- cord-010092-uftc8inx 7734 35 PCR PCR NNP cord-010092-uftc8inx 7734 36 ) ) -RRB- cord-010092-uftc8inx 7734 37 . . . cord-010092-uftc8inx 7735 1 Aims aim VBZ cord-010092-uftc8inx 7735 2 : : : cord-010092-uftc8inx 7736 1 The the DT cord-010092-uftc8inx 7736 2 current current JJ cord-010092-uftc8inx 7736 3 study study NN cord-010092-uftc8inx 7736 4 was be VBD cord-010092-uftc8inx 7736 5 conducted conduct VBN cord-010092-uftc8inx 7736 6 to to TO cord-010092-uftc8inx 7736 7 evaluate evaluate VB cord-010092-uftc8inx 7736 8 the the DT cord-010092-uftc8inx 7736 9 performance performance NN cord-010092-uftc8inx 7736 10 and and CC cord-010092-uftc8inx 7736 11 screening screening NN cord-010092-uftc8inx 7736 12 effectiveness effectiveness NN cord-010092-uftc8inx 7736 13 of of IN cord-010092-uftc8inx 7736 14 commercially commercially RB cord-010092-uftc8inx 7736 15 available available JJ cord-010092-uftc8inx 7736 16 rapid rapid JJ cord-010092-uftc8inx 7736 17 screening screening NN cord-010092-uftc8inx 7736 18 kits kit NNS cord-010092-uftc8inx 7736 19 in in IN cord-010092-uftc8inx 7736 20 comparison comparison NN cord-010092-uftc8inx 7736 21 with with IN cord-010092-uftc8inx 7736 22 CLIA CLIA NNP cord-010092-uftc8inx 7736 23 and and CC cord-010092-uftc8inx 7736 24 PCR PCR NNP cord-010092-uftc8inx 7736 25 . . . cord-010092-uftc8inx 7737 1 Methods method NNS cord-010092-uftc8inx 7737 2 : : : cord-010092-uftc8inx 7738 1 This this DT cord-010092-uftc8inx 7738 2 single single JJ cord-010092-uftc8inx 7738 3 centre centre NN cord-010092-uftc8inx 7738 4 , , , cord-010092-uftc8inx 7738 5 cross cross JJ cord-010092-uftc8inx 7738 6 sectional sectional JJ cord-010092-uftc8inx 7738 7 study study NN cord-010092-uftc8inx 7738 8 was be VBD cord-010092-uftc8inx 7738 9 conducted conduct VBN cord-010092-uftc8inx 7738 10 at at IN cord-010092-uftc8inx 7738 11 the the DT cord-010092-uftc8inx 7738 12 Department Department NNP cord-010092-uftc8inx 7738 13 of of IN cord-010092-uftc8inx 7738 14 Blood Blood NNP cord-010092-uftc8inx 7738 15 Transfusion Transfusion NNP cord-010092-uftc8inx 7738 16 Services Services NNPS cord-010092-uftc8inx 7738 17 , , , cord-010092-uftc8inx 7738 18 Shaheed Shaheed NNP cord-010092-uftc8inx 7738 19 Zulfiqar Zulfiqar NNP cord-010092-uftc8inx 7738 20 Ali Ali NNP cord-010092-uftc8inx 7738 21 Bhutto Bhutto NNP cord-010092-uftc8inx 7738 22 Medical Medical NNP cord-010092-uftc8inx 7738 23 University University NNP cord-010092-uftc8inx 7738 24 , , , cord-010092-uftc8inx 7738 25 Islamabad Islamabad NNP cord-010092-uftc8inx 7738 26 , , , cord-010092-uftc8inx 7738 27 from from IN cord-010092-uftc8inx 7738 28 January January NNP cord-010092-uftc8inx 7738 29 -June -June NNP cord-010092-uftc8inx 7738 30 2018 2018 CD cord-010092-uftc8inx 7738 31 . . . cord-010092-uftc8inx 7739 1 A a DT cord-010092-uftc8inx 7739 2 total total NN cord-010092-uftc8inx 7739 3 of of IN cord-010092-uftc8inx 7739 4 ten ten CD cord-010092-uftc8inx 7739 5 commercially commercially RB cord-010092-uftc8inx 7739 6 available available JJ cord-010092-uftc8inx 7739 7 ICT ICT NNP cord-010092-uftc8inx 7739 8 devices device NNS cord-010092-uftc8inx 7739 9 and and CC cord-010092-uftc8inx 7739 10 one one CD cord-010092-uftc8inx 7739 11 CLIA CLIA NNP cord-010092-uftc8inx 7739 12 kit kit NN cord-010092-uftc8inx 7739 13 ( ( -LRB- cord-010092-uftc8inx 7739 14 LIAISONR LIAISONR NNP cord-010092-uftc8inx 7739 15 XL XL NNP cord-010092-uftc8inx 7739 16 ) ) -RRB- cord-010092-uftc8inx 7739 17 were be VBD cord-010092-uftc8inx 7739 18 tested test VBN cord-010092-uftc8inx 7739 19 for for IN cord-010092-uftc8inx 7739 20 their -PRON- PRP$ cord-010092-uftc8inx 7739 21 sensitivity sensitivity NN cord-010092-uftc8inx 7739 22 , , , cord-010092-uftc8inx 7739 23 specificity specificity NN cord-010092-uftc8inx 7739 24 , , , cord-010092-uftc8inx 7739 25 positive positive JJ cord-010092-uftc8inx 7739 26 predictive predictive JJ cord-010092-uftc8inx 7739 27 value value NN cord-010092-uftc8inx 7739 28 ( ( -LRB- cord-010092-uftc8inx 7739 29 PPV PPV NNP cord-010092-uftc8inx 7739 30 ) ) -RRB- cord-010092-uftc8inx 7739 31 , , , cord-010092-uftc8inx 7739 32 negative negative JJ cord-010092-uftc8inx 7739 33 predictive predictive JJ cord-010092-uftc8inx 7739 34 value value NN cord-010092-uftc8inx 7739 35 ( ( -LRB- cord-010092-uftc8inx 7739 36 NPV NPV NNP cord-010092-uftc8inx 7739 37 ) ) -RRB- cord-010092-uftc8inx 7739 38 and and CC cord-010092-uftc8inx 7739 39 accuracy accuracy NN cord-010092-uftc8inx 7739 40 using use VBG cord-010092-uftc8inx 7739 41 100 100 CD cord-010092-uftc8inx 7739 42 positive positive JJ cord-010092-uftc8inx 7739 43 and and CC cord-010092-uftc8inx 7739 44 100 100 CD cord-010092-uftc8inx 7739 45 negative negative JJ cord-010092-uftc8inx 7739 46 samples sample NNS cord-010092-uftc8inx 7739 47 each each DT cord-010092-uftc8inx 7739 48 for for IN cord-010092-uftc8inx 7739 49 HBV HBV NNP cord-010092-uftc8inx 7739 50 and and CC cord-010092-uftc8inx 7739 51 HCV HCV NNP cord-010092-uftc8inx 7739 52 respectively respectively RB cord-010092-uftc8inx 7739 53 , , , cord-010092-uftc8inx 7739 54 in in IN cord-010092-uftc8inx 7739 55 comparison comparison NN cord-010092-uftc8inx 7739 56 with with IN cord-010092-uftc8inx 7739 57 the the DT cord-010092-uftc8inx 7739 58 values value NNS cord-010092-uftc8inx 7739 59 determined determine VBN cord-010092-uftc8inx 7739 60 by by IN cord-010092-uftc8inx 7739 61 PCR PCR NNP cord-010092-uftc8inx 7739 62 . . . cord-010092-uftc8inx 7740 1 The the DT cord-010092-uftc8inx 7740 2 ICT ICT NNP cord-010092-uftc8inx 7740 3 kits kit NNS cord-010092-uftc8inx 7740 4 included include VBD cord-010092-uftc8inx 7740 5 Hightop Hightop NNP cord-010092-uftc8inx 7740 6 , , , cord-010092-uftc8inx 7740 7 RightSign RightSign NNP cord-010092-uftc8inx 7740 8 , , , cord-010092-uftc8inx 7740 9 Wondfo Wondfo NNP cord-010092-uftc8inx 7740 10 , , , cord-010092-uftc8inx 7740 11 Accu Accu NNP cord-010092-uftc8inx 7740 12 - - HYPH cord-010092-uftc8inx 7740 13 Chek Chek NNP cord-010092-uftc8inx 7740 14 , , , cord-010092-uftc8inx 7740 15 Fastep Fastep NNP cord-010092-uftc8inx 7740 16 , , , cord-010092-uftc8inx 7740 17 Abon Abon NNP cord-010092-uftc8inx 7740 18 , , , cord-010092-uftc8inx 7740 19 ImmuMed ImmuMed NNP cord-010092-uftc8inx 7740 20 , , , cord-010092-uftc8inx 7740 21 Insta Insta NNP cord-010092-uftc8inx 7740 22 - - HYPH cord-010092-uftc8inx 7740 23 Answer Answer NNP cord-010092-uftc8inx 7740 24 , , , cord-010092-uftc8inx 7740 25 BioCheck BioCheck NNP cord-010092-uftc8inx 7740 26 and and CC cord-010092-uftc8inx 7740 27 CTK CTK NNP cord-010092-uftc8inx 7740 28 . . . cord-010092-uftc8inx 7741 1 Results result NNS cord-010092-uftc8inx 7741 2 : : : cord-010092-uftc8inx 7742 1 The the DT cord-010092-uftc8inx 7742 2 sensitivities sensitivity NNS cord-010092-uftc8inx 7742 3 and and CC cord-010092-uftc8inx 7742 4 specificities specificity NNS cord-010092-uftc8inx 7742 5 of of IN cord-010092-uftc8inx 7742 6 ICT ICT NNP cord-010092-uftc8inx 7742 7 kits kit NNS cord-010092-uftc8inx 7742 8 for for IN cord-010092-uftc8inx 7742 9 HBsAg HBsAg NNP cord-010092-uftc8inx 7742 10 were be VBD cord-010092-uftc8inx 7742 11 65 65 CD cord-010092-uftc8inx 7742 12 % % NN cord-010092-uftc8inx 7742 13 and and CC cord-010092-uftc8inx 7742 14 70 70 CD cord-010092-uftc8inx 7742 15 % % NN cord-010092-uftc8inx 7742 16 ( ( -LRB- cord-010092-uftc8inx 7742 17 Hightop Hightop NNP cord-010092-uftc8inx 7742 18 ) ) -RRB- cord-010092-uftc8inx 7742 19 , , , cord-010092-uftc8inx 7742 20 67 67 CD cord-010092-uftc8inx 7742 21 % % NN cord-010092-uftc8inx 7742 22 and and CC cord-010092-uftc8inx 7742 23 85 85 CD cord-010092-uftc8inx 7742 24 % % NN cord-010092-uftc8inx 7742 25 ( ( -LRB- cord-010092-uftc8inx 7742 26 RightSign RightSign NNP cord-010092-uftc8inx 7742 27 ) ) -RRB- cord-010092-uftc8inx 7742 28 , , , cord-010092-uftc8inx 7742 29 62 62 CD cord-010092-uftc8inx 7742 30 % % NN cord-010092-uftc8inx 7742 31 and and CC cord-010092-uftc8inx 7742 32 73 73 CD cord-010092-uftc8inx 7742 33 % % NN cord-010092-uftc8inx 7742 34 ( ( -LRB- cord-010092-uftc8inx 7742 35 Wondfo Wondfo NNP cord-010092-uftc8inx 7742 36 ) ) -RRB- cord-010092-uftc8inx 7742 37 , , , cord-010092-uftc8inx 7742 38 70 70 CD cord-010092-uftc8inx 7742 39 % % NN cord-010092-uftc8inx 7742 40 and and CC cord-010092-uftc8inx 7742 41 80 80 CD cord-010092-uftc8inx 7742 42 % % NN cord-010092-uftc8inx 7743 1 ( ( -LRB- cord-010092-uftc8inx 7743 2 Accu Accu NNP cord-010092-uftc8inx 7743 3 - - HYPH cord-010092-uftc8inx 7743 4 Chek Chek NNP cord-010092-uftc8inx 7743 5 ) ) -RRB- cord-010092-uftc8inx 7743 6 , , , cord-010092-uftc8inx 7743 7 68 68 CD cord-010092-uftc8inx 7743 8 % % NN cord-010092-uftc8inx 7743 9 and and CC cord-010092-uftc8inx 7743 10 77 77 CD cord-010092-uftc8inx 7743 11 % % NN cord-010092-uftc8inx 7743 12 ( ( -LRB- cord-010092-uftc8inx 7743 13 Fastep Fastep NNP cord-010092-uftc8inx 7743 14 ) ) -RRB- cord-010092-uftc8inx 7743 15 , , , cord-010092-uftc8inx 7743 16 73 73 CD cord-010092-uftc8inx 7743 17 % % NN cord-010092-uftc8inx 7743 18 and and CC cord-010092-uftc8inx 7743 19 85 85 CD cord-010092-uftc8inx 7743 20 % % NN cord-010092-uftc8inx 7743 21 ( ( -LRB- cord-010092-uftc8inx 7743 22 Abon Abon NNP cord-010092-uftc8inx 7743 23 ) ) -RRB- cord-010092-uftc8inx 7743 24 , , , cord-010092-uftc8inx 7743 25 77 77 CD cord-010092-uftc8inx 7743 26 % % NN cord-010092-uftc8inx 7743 27 and and CC cord-010092-uftc8inx 7743 28 83 83 CD cord-010092-uftc8inx 7743 29 % % NN cord-010092-uftc8inx 7743 30 ( ( -LRB- cord-010092-uftc8inx 7743 31 ImmuMed ImmuMed NNP cord-010092-uftc8inx 7743 32 ) ) -RRB- cord-010092-uftc8inx 7743 33 , , , cord-010092-uftc8inx 7743 34 80 80 CD cord-010092-uftc8inx 7743 35 % % NN cord-010092-uftc8inx 7743 36 and and CC cord-010092-uftc8inx 7743 37 90 90 CD cord-010092-uftc8inx 7743 38 % % NN cord-010092-uftc8inx 7744 1 ( ( -LRB- cord-010092-uftc8inx 7744 2 Insta Insta NNP cord-010092-uftc8inx 7744 3 - - HYPH cord-010092-uftc8inx 7744 4 Answer Answer NNP cord-010092-uftc8inx 7744 5 ) ) -RRB- cord-010092-uftc8inx 7744 6 , , , cord-010092-uftc8inx 7744 7 67 67 CD cord-010092-uftc8inx 7744 8 % % NN cord-010092-uftc8inx 7744 9 and and CC cord-010092-uftc8inx 7744 10 81 81 CD cord-010092-uftc8inx 7744 11 % % NN cord-010092-uftc8inx 7744 12 ( ( -LRB- cord-010092-uftc8inx 7744 13 BioCheck BioCheck NNP cord-010092-uftc8inx 7744 14 ) ) -RRB- cord-010092-uftc8inx 7744 15 and and CC cord-010092-uftc8inx 7744 16 72 72 CD cord-010092-uftc8inx 7744 17 % % NN cord-010092-uftc8inx 7744 18 and and CC cord-010092-uftc8inx 7744 19 83 83 CD cord-010092-uftc8inx 7744 20 % % NN cord-010092-uftc8inx 7744 21 ( ( -LRB- cord-010092-uftc8inx 7744 22 CTK CTK NNP cord-010092-uftc8inx 7744 23 ) ) -RRB- cord-010092-uftc8inx 7744 24 respectively respectively RB cord-010092-uftc8inx 7744 25 . . . cord-010092-uftc8inx 7745 1 Similarly similarly RB cord-010092-uftc8inx 7745 2 the the DT cord-010092-uftc8inx 7745 3 sensitivities sensitivity NNS cord-010092-uftc8inx 7745 4 and and CC cord-010092-uftc8inx 7745 5 specificities specificity NNS cord-010092-uftc8inx 7745 6 of of IN cord-010092-uftc8inx 7745 7 different different JJ cord-010092-uftc8inx 7745 8 ICT ict NN cord-010092-uftc8inx 7745 9 kits kit NNS cord-010092-uftc8inx 7745 10 for for IN cord-010092-uftc8inx 7745 11 HCV HCV NNP cord-010092-uftc8inx 7745 12 were be VBD cord-010092-uftc8inx 7745 13 69 69 CD cord-010092-uftc8inx 7745 14 % % NN cord-010092-uftc8inx 7745 15 and and CC cord-010092-uftc8inx 7745 16 80 80 CD cord-010092-uftc8inx 7745 17 % % NN cord-010092-uftc8inx 7745 18 ( ( -LRB- cord-010092-uftc8inx 7745 19 Hightop Hightop NNP cord-010092-uftc8inx 7745 20 ) ) -RRB- cord-010092-uftc8inx 7745 21 , , , cord-010092-uftc8inx 7745 22 76 76 CD cord-010092-uftc8inx 7745 23 % % NN cord-010092-uftc8inx 7745 24 and and CC cord-010092-uftc8inx 7745 25 83 83 CD cord-010092-uftc8inx 7745 26 % % NN cord-010092-uftc8inx 7745 27 ( ( -LRB- cord-010092-uftc8inx 7745 28 RightSign RightSign NNP cord-010092-uftc8inx 7745 29 ) ) -RRB- cord-010092-uftc8inx 7745 30 , , , cord-010092-uftc8inx 7745 31 69 69 CD cord-010092-uftc8inx 7745 32 % % NN cord-010092-uftc8inx 7745 33 and and CC cord-010092-uftc8inx 7745 34 81 81 CD cord-010092-uftc8inx 7745 35 % % NN cord-010092-uftc8inx 7746 1 ( ( -LRB- cord-010092-uftc8inx 7746 2 Wondfo Wondfo NNP cord-010092-uftc8inx 7746 3 ) ) -RRB- cord-010092-uftc8inx 7746 4 , , , cord-010092-uftc8inx 7746 5 78 78 CD cord-010092-uftc8inx 7746 6 % % NN cord-010092-uftc8inx 7746 7 and and CC cord-010092-uftc8inx 7746 8 79 79 CD cord-010092-uftc8inx 7746 9 % % NN cord-010092-uftc8inx 7746 10 ( ( -LRB- cord-010092-uftc8inx 7746 11 Accu Accu NNP cord-010092-uftc8inx 7746 12 Check Check NNP cord-010092-uftc8inx 7746 13 ) ) -RRB- cord-010092-uftc8inx 7746 14 , , , cord-010092-uftc8inx 7746 15 68 68 CD cord-010092-uftc8inx 7746 16 % % NN cord-010092-uftc8inx 7746 17 and and CC cord-010092-uftc8inx 7746 18 68 68 CD cord-010092-uftc8inx 7746 19 % % NN cord-010092-uftc8inx 7746 20 ( ( -LRB- cord-010092-uftc8inx 7746 21 Fastep Fastep NNP cord-010092-uftc8inx 7746 22 ) ) -RRB- cord-010092-uftc8inx 7746 23 , , , cord-010092-uftc8inx 7746 24 63 63 CD cord-010092-uftc8inx 7746 25 % % NN cord-010092-uftc8inx 7746 26 and and CC cord-010092-uftc8inx 7746 27 73 73 CD cord-010092-uftc8inx 7746 28 % % NN cord-010092-uftc8inx 7747 1 ( ( -LRB- cord-010092-uftc8inx 7747 2 Abon Abon NNP cord-010092-uftc8inx 7747 3 ) ) -RRB- cord-010092-uftc8inx 7747 4 , , , cord-010092-uftc8inx 7747 5 71 71 CD cord-010092-uftc8inx 7747 6 % % NN cord-010092-uftc8inx 7747 7 and and CC cord-010092-uftc8inx 7747 8 70 70 CD cord-010092-uftc8inx 7747 9 % % NN cord-010092-uftc8inx 7747 10 ( ( -LRB- cord-010092-uftc8inx 7747 11 Immu Immu NNP cord-010092-uftc8inx 7747 12 - - HYPH cord-010092-uftc8inx 7747 13 Med Med NNP cord-010092-uftc8inx 7747 14 ) ) -RRB- cord-010092-uftc8inx 7747 15 , , , cord-010092-uftc8inx 7747 16 79 79 CD cord-010092-uftc8inx 7747 17 % % NN cord-010092-uftc8inx 7747 18 and and CC cord-010092-uftc8inx 7747 19 68 68 CD cord-010092-uftc8inx 7747 20 % % NN cord-010092-uftc8inx 7747 21 ( ( -LRB- cord-010092-uftc8inx 7747 22 Insta Insta NNP cord-010092-uftc8inx 7747 23 Answer Answer NNP cord-010092-uftc8inx 7747 24 ) ) -RRB- cord-010092-uftc8inx 7747 25 , , , cord-010092-uftc8inx 7747 26 62 62 CD cord-010092-uftc8inx 7747 27 % % NN cord-010092-uftc8inx 7747 28 and and CC cord-010092-uftc8inx 7747 29 66 66 CD cord-010092-uftc8inx 7747 30 % % NN cord-010092-uftc8inx 7747 31 ( ( -LRB- cord-010092-uftc8inx 7747 32 BioChek BioChek NNP cord-010092-uftc8inx 7747 33 ) ) -RRB- cord-010092-uftc8inx 7747 34 and and CC cord-010092-uftc8inx 7747 35 69 69 CD cord-010092-uftc8inx 7747 36 % % NN cord-010092-uftc8inx 7747 37 and and CC cord-010092-uftc8inx 7747 38 78 78 CD cord-010092-uftc8inx 7747 39 % % NN cord-010092-uftc8inx 7747 40 ( ( -LRB- cord-010092-uftc8inx 7747 41 CTK CTK NNP cord-010092-uftc8inx 7747 42 ) ) -RRB- cord-010092-uftc8inx 7747 43 respectively respectively RB cord-010092-uftc8inx 7747 44 . . . cord-010092-uftc8inx 7748 1 The the DT cord-010092-uftc8inx 7748 2 sensitivity sensitivity NN cord-010092-uftc8inx 7748 3 and and CC cord-010092-uftc8inx 7748 4 specificity specificity NN cord-010092-uftc8inx 7748 5 of of IN cord-010092-uftc8inx 7748 6 Diasorin Diasorin NNP cord-010092-uftc8inx 7748 7 Liaison Liaison NNP cord-010092-uftc8inx 7748 8 Murex Murex NNP cord-010092-uftc8inx 7748 9 assay assay NN cord-010092-uftc8inx 7748 10 for for IN cord-010092-uftc8inx 7748 11 both both CC cord-010092-uftc8inx 7748 12 HBV HBV NNP cord-010092-uftc8inx 7748 13 and and CC cord-010092-uftc8inx 7748 14 HCV HCV NNP cord-010092-uftc8inx 7748 15 were be VBD cord-010092-uftc8inx 7748 16 found find VBN cord-010092-uftc8inx 7748 17 to to TO cord-010092-uftc8inx 7748 18 be be VB cord-010092-uftc8inx 7748 19 100 100 CD cord-010092-uftc8inx 7748 20 % % NN cord-010092-uftc8inx 7748 21 , , , cord-010092-uftc8inx 7748 22 when when WRB cord-010092-uftc8inx 7748 23 compared compare VBN cord-010092-uftc8inx 7748 24 with with IN cord-010092-uftc8inx 7748 25 PCR PCR NNP cord-010092-uftc8inx 7748 26 . . . cord-010092-uftc8inx 7749 1 The the DT cord-010092-uftc8inx 7749 2 PPV PPV NNP cord-010092-uftc8inx 7749 3 , , , cord-010092-uftc8inx 7749 4 NPV NPV NNP cord-010092-uftc8inx 7749 5 and and CC cord-010092-uftc8inx 7749 6 Accuracy Accuracy NNP cord-010092-uftc8inx 7749 7 were be VBD cord-010092-uftc8inx 7749 8 determined determine VBN cord-010092-uftc8inx 7749 9 accordingly accordingly RB cord-010092-uftc8inx 7749 10 . . . cord-010092-uftc8inx 7750 1 Summary Summary NNP cord-010092-uftc8inx 7750 2 / / SYM cord-010092-uftc8inx 7750 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 7750 4 : : : cord-010092-uftc8inx 7751 1 Rapid rapid JJ cord-010092-uftc8inx 7751 2 testing test VBG cord-010092-uftc8inx 7751 3 ICT ict NN cord-010092-uftc8inx 7751 4 devices device NNS cord-010092-uftc8inx 7751 5 for for IN cord-010092-uftc8inx 7751 6 both both CC cord-010092-uftc8inx 7751 7 HBV HBV NNP cord-010092-uftc8inx 7751 8 and and CC cord-010092-uftc8inx 7751 9 HCV HCV NNP cord-010092-uftc8inx 7751 10 available available JJ cord-010092-uftc8inx 7751 11 in in IN cord-010092-uftc8inx 7751 12 Pakistan Pakistan NNP cord-010092-uftc8inx 7751 13 were be VBD cord-010092-uftc8inx 7751 14 found find VBN cord-010092-uftc8inx 7751 15 to to TO cord-010092-uftc8inx 7751 16 have have VB cord-010092-uftc8inx 7751 17 a a DT cord-010092-uftc8inx 7751 18 variable variable JJ cord-010092-uftc8inx 7751 19 degree degree NN cord-010092-uftc8inx 7751 20 of of IN cord-010092-uftc8inx 7751 21 sensitivity sensitivity NN cord-010092-uftc8inx 7751 22 and and CC cord-010092-uftc8inx 7751 23 specificity specificity NN cord-010092-uftc8inx 7751 24 , , , cord-010092-uftc8inx 7751 25 when when WRB cord-010092-uftc8inx 7751 26 compared compare VBN cord-010092-uftc8inx 7751 27 with with IN cord-010092-uftc8inx 7751 28 PCR PCR NNP cord-010092-uftc8inx 7751 29 . . . cord-010092-uftc8inx 7752 1 Comparatively comparatively RB cord-010092-uftc8inx 7752 2 expensive expensive JJ cord-010092-uftc8inx 7752 3 but but CC cord-010092-uftc8inx 7752 4 quality quality NN cord-010092-uftc8inx 7752 5 methods method NNS cord-010092-uftc8inx 7752 6 are be VBP cord-010092-uftc8inx 7752 7 more more RBR cord-010092-uftc8inx 7752 8 reliable reliable JJ cord-010092-uftc8inx 7752 9 as as IN cord-010092-uftc8inx 7752 10 compared compare VBN cord-010092-uftc8inx 7752 11 to to IN cord-010092-uftc8inx 7752 12 rapid rapid JJ cord-010092-uftc8inx 7752 13 devices device NNS cord-010092-uftc8inx 7752 14 . . . cord-010092-uftc8inx 7753 1 The the DT cord-010092-uftc8inx 7753 2 data datum NNS cord-010092-uftc8inx 7753 3 generated generate VBN cord-010092-uftc8inx 7753 4 will will MD cord-010092-uftc8inx 7753 5 help help VB cord-010092-uftc8inx 7753 6 policy policy NN cord-010092-uftc8inx 7753 7 makers maker NNS cord-010092-uftc8inx 7753 8 to to TO cord-010092-uftc8inx 7753 9 prepare prepare VB cord-010092-uftc8inx 7753 10 future future JJ cord-010092-uftc8inx 7753 11 plan plan NN cord-010092-uftc8inx 7753 12 of of IN cord-010092-uftc8inx 7753 13 action action NN cord-010092-uftc8inx 7753 14 and and CC cord-010092-uftc8inx 7753 15 introduce introduce VB cord-010092-uftc8inx 7753 16 the the DT cord-010092-uftc8inx 7753 17 concept concept NN cord-010092-uftc8inx 7753 18 of of IN cord-010092-uftc8inx 7753 19 quality quality NN cord-010092-uftc8inx 7753 20 control control NN cord-010092-uftc8inx 7753 21 in in IN cord-010092-uftc8inx 7753 22 blood blood NN cord-010092-uftc8inx 7753 23 centres centre NNS cord-010092-uftc8inx 7753 24 . . . cord-010092-uftc8inx 7754 1 The the DT cord-010092-uftc8inx 7754 2 analysis analysis NN cord-010092-uftc8inx 7754 3 has have VBZ cord-010092-uftc8inx 7754 4 shown show VBN cord-010092-uftc8inx 7754 5 that that IN cord-010092-uftc8inx 7754 6 the the DT cord-010092-uftc8inx 7754 7 population population NN cord-010092-uftc8inx 7754 8 of of IN cord-010092-uftc8inx 7754 9 blood blood NN cord-010092-uftc8inx 7754 10 donors donor NNS cord-010092-uftc8inx 7754 11 also also RB cord-010092-uftc8inx 7754 12 included include VBD cord-010092-uftc8inx 7754 13 people people NNS cord-010092-uftc8inx 7754 14 infected infect VBN cord-010092-uftc8inx 7754 15 with with IN cord-010092-uftc8inx 7754 16 syphilis syphili NNS cord-010092-uftc8inx 7754 17 . . . cord-010092-uftc8inx 7755 1 In in IN cord-010092-uftc8inx 7755 2 reference reference NN cord-010092-uftc8inx 7755 3 to to IN cord-010092-uftc8inx 7755 4 the the DT cord-010092-uftc8inx 7755 5 number number NN cord-010092-uftc8inx 7755 6 of of IN cord-010092-uftc8inx 7755 7 the the DT cord-010092-uftc8inx 7755 8 tested test VBN cord-010092-uftc8inx 7755 9 samples sample NNS cord-010092-uftc8inx 7755 10 this this DT cord-010092-uftc8inx 7755 11 number number NN cord-010092-uftc8inx 7755 12 is be VBZ cord-010092-uftc8inx 7755 13 quite quite RB cord-010092-uftc8inx 7755 14 significant significant JJ cord-010092-uftc8inx 7755 15 . . . cord-010092-uftc8inx 7756 1 The the DT cord-010092-uftc8inx 7756 2 analysis analysis NN cord-010092-uftc8inx 7756 3 proved prove VBD cord-010092-uftc8inx 7756 4 the the DT cord-010092-uftc8inx 7756 5 increase increase NN cord-010092-uftc8inx 7756 6 in in IN cord-010092-uftc8inx 7756 7 the the DT cord-010092-uftc8inx 7756 8 number number NN cord-010092-uftc8inx 7756 9 of of IN cord-010092-uftc8inx 7756 10 syphilis syphili NNS cord-010092-uftc8inx 7756 11 infections infection NNS cord-010092-uftc8inx 7756 12 among among IN cord-010092-uftc8inx 7756 13 the the DT cord-010092-uftc8inx 7756 14 blood blood NN cord-010092-uftc8inx 7756 15 donors donor NNS cord-010092-uftc8inx 7756 16 which which WDT cord-010092-uftc8inx 7756 17 is be VBZ cord-010092-uftc8inx 7756 18 consistent consistent JJ cord-010092-uftc8inx 7756 19 with with IN cord-010092-uftc8inx 7756 20 the the DT cord-010092-uftc8inx 7756 21 general general JJ cord-010092-uftc8inx 7756 22 trend trend NN cord-010092-uftc8inx 7756 23 in in IN cord-010092-uftc8inx 7756 24 the the DT cord-010092-uftc8inx 7756 25 population population NN cord-010092-uftc8inx 7756 26 . . . cord-010092-uftc8inx 7757 1 Summary Summary NNP cord-010092-uftc8inx 7757 2 / / SYM cord-010092-uftc8inx 7757 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 7757 4 : : : cord-010092-uftc8inx 7758 1 We -PRON- PRP cord-010092-uftc8inx 7758 2 have have VBP cord-010092-uftc8inx 7758 3 proved prove VBN cord-010092-uftc8inx 7758 4 that that IN cord-010092-uftc8inx 7758 5 testing test VBG cord-010092-uftc8inx 7758 6 blood blood NN cord-010092-uftc8inx 7758 7 donors donor NNS cord-010092-uftc8inx 7758 8 for for IN cord-010092-uftc8inx 7758 9 the the DT cord-010092-uftc8inx 7758 10 Treponema Treponema NNP cord-010092-uftc8inx 7758 11 pallidum pallidum NN cord-010092-uftc8inx 7758 12 infection infection NN cord-010092-uftc8inx 7758 13 increases increase VBZ cord-010092-uftc8inx 7758 14 the the DT cord-010092-uftc8inx 7758 15 safety safety NN cord-010092-uftc8inx 7758 16 of of IN cord-010092-uftc8inx 7758 17 recipients recipient NNS cord-010092-uftc8inx 7758 18 of of IN cord-010092-uftc8inx 7758 19 blood blood NN cord-010092-uftc8inx 7758 20 and and CC cord-010092-uftc8inx 7758 21 its -PRON- PRP$ cord-010092-uftc8inx 7758 22 components component NNS cord-010092-uftc8inx 7758 23 and and CC cord-010092-uftc8inx 7758 24 that that IN cord-010092-uftc8inx 7758 25 obligatory obligatory JJ cord-010092-uftc8inx 7758 26 testing testing NN cord-010092-uftc8inx 7758 27 of of IN cord-010092-uftc8inx 7758 28 donors donor NNS cord-010092-uftc8inx 7758 29 is be VBZ cord-010092-uftc8inx 7758 30 fully fully RB cord-010092-uftc8inx 7758 31 justified justified JJ cord-010092-uftc8inx 7758 32 . . . cord-010092-uftc8inx 7759 1 , , , cord-010092-uftc8inx 7759 2 1940 1940 CD cord-010092-uftc8inx 7759 3 and and CC cord-010092-uftc8inx 7759 4 1945 1945 CD cord-010092-uftc8inx 7759 5 , , , cord-010092-uftc8inx 7759 6 the the DT cord-010092-uftc8inx 7759 7 use use NN cord-010092-uftc8inx 7759 8 of of IN cord-010092-uftc8inx 7759 9 third third JJ cord-010092-uftc8inx 7759 10 or or CC cord-010092-uftc8inx 7759 11 fourth fourth JJ cord-010092-uftc8inx 7759 12 generation generation NN cord-010092-uftc8inx 7759 13 serological serological JJ cord-010092-uftc8inx 7759 14 assays assay NNS cord-010092-uftc8inx 7759 15 is be VBZ cord-010092-uftc8inx 7759 16 mandatory mandatory JJ cord-010092-uftc8inx 7759 17 for for IN cord-010092-uftc8inx 7759 18 screening screening NN cord-010092-uftc8inx 7759 19 of of IN cord-010092-uftc8inx 7759 20 blood blood NN cord-010092-uftc8inx 7759 21 donor donor NN cord-010092-uftc8inx 7759 22 units unit NNS cord-010092-uftc8inx 7759 23 for for IN cord-010092-uftc8inx 7759 24 HBV HBV NNP cord-010092-uftc8inx 7759 25 and and CC cord-010092-uftc8inx 7759 26 HCV HCV NNP cord-010092-uftc8inx 7759 27 infection infection NN cord-010092-uftc8inx 7759 28 before before IN cord-010092-uftc8inx 7759 29 transfusion transfusion NN cord-010092-uftc8inx 7759 30 . . . cord-010092-uftc8inx 7760 1 Routinely routinely RB cord-010092-uftc8inx 7760 2 , , , cord-010092-uftc8inx 7760 3 blood blood NN cord-010092-uftc8inx 7760 4 banks bank NNS cord-010092-uftc8inx 7760 5 in in IN cord-010092-uftc8inx 7760 6 India India NNP cord-010092-uftc8inx 7760 7 screen screen VBP cord-010092-uftc8inx 7760 8 the the DT cord-010092-uftc8inx 7760 9 units unit NNS cord-010092-uftc8inx 7760 10 by by IN cord-010092-uftc8inx 7760 11 the the DT cord-010092-uftc8inx 7760 12 ELISA ELISA NNP cord-010092-uftc8inx 7760 13 testing testing NN cord-010092-uftc8inx 7760 14 . . . cord-010092-uftc8inx 7761 1 NAT NAT NNP cord-010092-uftc8inx 7761 2 is be VBZ cord-010092-uftc8inx 7761 3 not not RB cord-010092-uftc8inx 7761 4 very very RB cord-010092-uftc8inx 7761 5 common common JJ cord-010092-uftc8inx 7761 6 due due IN cord-010092-uftc8inx 7761 7 to to IN cord-010092-uftc8inx 7761 8 cost cost NN cord-010092-uftc8inx 7761 9 constraints constraint NNS cord-010092-uftc8inx 7761 10 . . . cord-010092-uftc8inx 7762 1 Aims aim VBZ cord-010092-uftc8inx 7762 2 : : : cord-010092-uftc8inx 7763 1 The the DT cord-010092-uftc8inx 7763 2 aim aim NN cord-010092-uftc8inx 7763 3 of of IN cord-010092-uftc8inx 7763 4 this this DT cord-010092-uftc8inx 7763 5 study study NN cord-010092-uftc8inx 7763 6 is be VBZ cord-010092-uftc8inx 7763 7 to to TO cord-010092-uftc8inx 7763 8 determine determine VB cord-010092-uftc8inx 7763 9 the the DT cord-010092-uftc8inx 7763 10 frequency frequency NN cord-010092-uftc8inx 7763 11 and and CC cord-010092-uftc8inx 7763 12 load load NN cord-010092-uftc8inx 7763 13 of of IN cord-010092-uftc8inx 7763 14 HBV HBV NNP cord-010092-uftc8inx 7763 15 DNA DNA NNP cord-010092-uftc8inx 7763 16 and and CC cord-010092-uftc8inx 7763 17 HCV HCV NNP cord-010092-uftc8inx 7763 18 RNA RNA NNP cord-010092-uftc8inx 7763 19 in in IN cord-010092-uftc8inx 7763 20 HBS HBS NNP cord-010092-uftc8inx 7763 21 and and CC cord-010092-uftc8inx 7763 22 HCV HCV NNP cord-010092-uftc8inx 7763 23 reactive reactive JJ cord-010092-uftc8inx 7763 24 blood blood NN cord-010092-uftc8inx 7763 25 donors donor NNS cord-010092-uftc8inx 7763 26 respectively respectively RB cord-010092-uftc8inx 7763 27 , , , cord-010092-uftc8inx 7763 28 and and CC cord-010092-uftc8inx 7763 29 hence hence RB cord-010092-uftc8inx 7763 30 it -PRON- PRP cord-010092-uftc8inx 7763 31 was be VBD cord-010092-uftc8inx 7763 32 intended intend VBN cord-010092-uftc8inx 7763 33 to to TO cord-010092-uftc8inx 7763 34 contribute contribute VB cord-010092-uftc8inx 7763 35 to to IN cord-010092-uftc8inx 7763 36 determining determine VBG cord-010092-uftc8inx 7763 37 whether whether IN cord-010092-uftc8inx 7763 38 routine routine JJ cord-010092-uftc8inx 7763 39 HBS HBS NNP cord-010092-uftc8inx 7763 40 and and CC cord-010092-uftc8inx 7763 41 HCV HCV NNP cord-010092-uftc8inx 7763 42 screening screening NN cord-010092-uftc8inx 7763 43 of of IN cord-010092-uftc8inx 7763 44 blood blood NN cord-010092-uftc8inx 7763 45 donors donor NNS cord-010092-uftc8inx 7763 46 , , , cord-010092-uftc8inx 7763 47 using use VBG cord-010092-uftc8inx 7763 48 ELISA ELISA NNP cord-010092-uftc8inx 7763 49 method method NN cord-010092-uftc8inx 7763 50 alone alone RB cord-010092-uftc8inx 7763 51 , , , cord-010092-uftc8inx 7763 52 provides provide VBZ cord-010092-uftc8inx 7763 53 any any DT cord-010092-uftc8inx 7763 54 concrete concrete JJ cord-010092-uftc8inx 7763 55 benefits benefit NNS cord-010092-uftc8inx 7763 56 with with IN cord-010092-uftc8inx 7763 57 regard regard NN cord-010092-uftc8inx 7763 58 to to IN cord-010092-uftc8inx 7763 59 HBV HBV NNP cord-010092-uftc8inx 7763 60 and and CC cord-010092-uftc8inx 7763 61 HCV HCV NNP cord-010092-uftc8inx 7763 62 risk risk NN cord-010092-uftc8inx 7763 63 reduction reduction NN cord-010092-uftc8inx 7763 64 or or CC cord-010092-uftc8inx 7763 65 whether whether IN cord-010092-uftc8inx 7763 66 the the DT cord-010092-uftc8inx 7763 67 implementation implementation NN cord-010092-uftc8inx 7763 68 of of IN cord-010092-uftc8inx 7763 69 NAT NAT NNP cord-010092-uftc8inx 7763 70 will will MD cord-010092-uftc8inx 7763 71 be be VB cord-010092-uftc8inx 7763 72 of of IN cord-010092-uftc8inx 7763 73 great great JJ cord-010092-uftc8inx 7763 74 benefit benefit NN cord-010092-uftc8inx 7763 75 to to IN cord-010092-uftc8inx 7763 76 low low JJ cord-010092-uftc8inx 7763 77 - - HYPH cord-010092-uftc8inx 7763 78 resource resource NN cord-010092-uftc8inx 7763 79 countries country NNS cord-010092-uftc8inx 7763 80 like like IN cord-010092-uftc8inx 7763 81 India India NNP cord-010092-uftc8inx 7763 82 , , , cord-010092-uftc8inx 7763 83 which which WDT cord-010092-uftc8inx 7763 84 has have VBZ cord-010092-uftc8inx 7763 85 high high JJ cord-010092-uftc8inx 7763 86 prevalence prevalence NN cord-010092-uftc8inx 7763 87 of of IN cord-010092-uftc8inx 7763 88 HBV HBV NNP cord-010092-uftc8inx 7763 89 and and CC cord-010092-uftc8inx 7763 90 HCV HCV NNP cord-010092-uftc8inx 7763 91 . . . cord-010092-uftc8inx 7763 92 _SP cord-010092-uftc8inx 7764 1 Abstract Abstract NNP cord-010092-uftc8inx 7764 2 withdrawn withdraw VBN cord-010092-uftc8inx 7764 3 . . . cord-010092-uftc8inx 7765 1 , , , cord-010092-uftc8inx 7765 2 906 906 CD cord-010092-uftc8inx 7765 3 donors donor NNS cord-010092-uftc8inx 7765 4 were be VBD cord-010092-uftc8inx 7765 5 routinely routinely RB cord-010092-uftc8inx 7765 6 tested test VBN cord-010092-uftc8inx 7765 7 for for IN cord-010092-uftc8inx 7765 8 HBV HBV NNP cord-010092-uftc8inx 7765 9 DNA DNA NNP cord-010092-uftc8inx 7765 10 by by IN cord-010092-uftc8inx 7765 11 using use VBG cord-010092-uftc8inx 7765 12 CobasTaqscreen CobasTaqscreen NNP cord-010092-uftc8inx 7765 13 MPX-1 MPX-1 NNP cord-010092-uftc8inx 7765 14 and and CC cord-010092-uftc8inx 7765 15 MPX-2 MPX-2 NNP cord-010092-uftc8inx 7765 16 ( ( -LRB- cord-010092-uftc8inx 7765 17 Roche Roche NNP cord-010092-uftc8inx 7765 18 ) ) -RRB- cord-010092-uftc8inx 7765 19 or or CC cord-010092-uftc8inx 7765 20 ProCleix ProCleix NNP cord-010092-uftc8inx 7765 21 Ultrio Ultrio NNP cord-010092-uftc8inx 7765 22 and and CC cord-010092-uftc8inx 7765 23 Ultrio Ultrio NNP cord-010092-uftc8inx 7765 24 Plus plus CC cord-010092-uftc8inx 7765 25 ID ID NNP cord-010092-uftc8inx 7765 26 ( ( -LRB- cord-010092-uftc8inx 7765 27 Grifols Grifols NNP cord-010092-uftc8inx 7765 28 ) ) -RRB- cord-010092-uftc8inx 7765 29 assays assay NNS cord-010092-uftc8inx 7765 30 . . . cord-010092-uftc8inx 7766 1 OBI OBI NNP cord-010092-uftc8inx 7766 2 was be VBD cord-010092-uftc8inx 7766 3 confirmed confirm VBN cord-010092-uftc8inx 7766 4 by by IN cord-010092-uftc8inx 7766 5 repeat repeat NN cord-010092-uftc8inx 7766 6 DNA dna NN cord-010092-uftc8inx 7766 7 testing testing NN cord-010092-uftc8inx 7766 8 and and CC cord-010092-uftc8inx 7766 9 by by IN cord-010092-uftc8inx 7766 10 performing perform VBG cord-010092-uftc8inx 7766 11 additional additional JJ cord-010092-uftc8inx 7766 12 serological serological JJ cord-010092-uftc8inx 7766 13 and and CC cord-010092-uftc8inx 7766 14 molecular molecular JJ cord-010092-uftc8inx 7766 15 investigations investigation NNS cord-010092-uftc8inx 7766 16 on on IN cord-010092-uftc8inx 7766 17 index index NN cord-010092-uftc8inx 7766 18 and and CC cord-010092-uftc8inx 7766 19 follow follow NN cord-010092-uftc8inx 7766 20 - - HYPH cord-010092-uftc8inx 7766 21 up up NN cord-010092-uftc8inx 7766 22 samples sample NNS cord-010092-uftc8inx 7766 23 . . . cord-010092-uftc8inx 7767 1 Anti Anti NNP cord-010092-uftc8inx 7767 2 - - JJ cord-010092-uftc8inx 7767 3 HBs hb NNS cord-010092-uftc8inx 7767 4 concentrations concentration NNS cord-010092-uftc8inx 7767 5 were be VBD cord-010092-uftc8inx 7767 6 determined determined JJ cord-010092-uftc8inx 7767 7 and and CC cord-010092-uftc8inx 7767 8 anti anti JJ cord-010092-uftc8inx 7767 9 - - JJ cord-010092-uftc8inx 7767 10 HBc hbc JJ cord-010092-uftc8inx 7767 11 antibodies antibody NNS cord-010092-uftc8inx 7767 12 were be VBD cord-010092-uftc8inx 7767 13 tested test VBN cord-010092-uftc8inx 7767 14 with with IN cord-010092-uftc8inx 7767 15 three three CD cord-010092-uftc8inx 7767 16 distinct distinct JJ cord-010092-uftc8inx 7767 17 commercial commercial JJ cord-010092-uftc8inx 7767 18 CLIA CLIA NNP cord-010092-uftc8inx 7767 19 assays assay NNS cord-010092-uftc8inx 7767 20 ( ( -LRB- cord-010092-uftc8inx 7767 21 Anti anti JJ cord-010092-uftc8inx 7767 22 - - JJ cord-010092-uftc8inx 7767 23 HBc hbc JJ cord-010092-uftc8inx 7767 24 Elecsys Elecsys NNP cord-010092-uftc8inx 7767 25 Roche Roche NNP cord-010092-uftc8inx 7767 26 , , , cord-010092-uftc8inx 7767 27 Architect Architect NNP cord-010092-uftc8inx 7767 28 Anti Anti NNP cord-010092-uftc8inx 7767 29 - - JJ cord-010092-uftc8inx 7767 30 HBc hbc JJ cord-010092-uftc8inx 7767 31 II II NNP cord-010092-uftc8inx 7767 32 Abbott Abbott NNP cord-010092-uftc8inx 7767 33 , , , cord-010092-uftc8inx 7767 34 and and CC cord-010092-uftc8inx 7767 35 HISCL HISCL NNP cord-010092-uftc8inx 7767 36 Anti Anti NNP cord-010092-uftc8inx 7767 37 - - JJ cord-010092-uftc8inx 7767 38 HBc hbc JJ cord-010092-uftc8inx 7767 39 assay assay NN cord-010092-uftc8inx 7767 40 Sysmex Sysmex NNP cord-010092-uftc8inx 7767 41 ) ) -RRB- cord-010092-uftc8inx 7767 42 . . . cord-010092-uftc8inx 7768 1 HBV HBV NNP cord-010092-uftc8inx 7768 2 pre pre VBD cord-010092-uftc8inx 7768 3 - - NNP cord-010092-uftc8inx 7768 4 S S NNP cord-010092-uftc8inx 7768 5 / / SYM cord-010092-uftc8inx 7768 6 S S NNP cord-010092-uftc8inx 7768 7 , , , cord-010092-uftc8inx 7768 8 precore precore NN cord-010092-uftc8inx 7768 9 / / SYM cord-010092-uftc8inx 7768 10 core core NN cord-010092-uftc8inx 7768 11 and and CC cord-010092-uftc8inx 7768 12 BCP BCP NNP cord-010092-uftc8inx 7768 13 regions region NNS cord-010092-uftc8inx 7768 14 were be VBD cord-010092-uftc8inx 7768 15 PCRamplified pcramplifie VBN cord-010092-uftc8inx 7768 16 after after IN cord-010092-uftc8inx 7768 17 viral viral JJ cord-010092-uftc8inx 7768 18 particle particle NN cord-010092-uftc8inx 7768 19 concentration concentration NN cord-010092-uftc8inx 7768 20 and and CC cord-010092-uftc8inx 7768 21 viral viral JJ cord-010092-uftc8inx 7768 22 amplicons amplicon NNS cord-010092-uftc8inx 7768 23 were be VBD cord-010092-uftc8inx 7768 24 sequenced sequence VBN cord-010092-uftc8inx 7768 25 . . . cord-010092-uftc8inx 7769 1 Results result NNS cord-010092-uftc8inx 7769 2 : : : cord-010092-uftc8inx 7770 1 348 348 CD cord-010092-uftc8inx 7770 2 HBsAg-/DNA+ HBsAg-/DNA+ NNP cord-010092-uftc8inx 7770 3 donors donor NNS cord-010092-uftc8inx 7770 4 ( ( -LRB- cord-010092-uftc8inx 7770 5 1:1,462 1:1,462 CD cord-010092-uftc8inx 7770 6 ) ) -RRB- cord-010092-uftc8inx 7770 7 including include VBG cord-010092-uftc8inx 7770 8 294 294 CD cord-010092-uftc8inx 7770 9 confirmed confirm VBN cord-010092-uftc8inx 7770 10 OBI OBI NNP cord-010092-uftc8inx 7770 11 were be VBD cord-010092-uftc8inx 7770 12 identified identify VBN cord-010092-uftc8inx 7770 13 ( ( -LRB- cord-010092-uftc8inx 7770 14 1:1,731 1:1,731 CD cord-010092-uftc8inx 7770 15 prevalence prevalence NN cord-010092-uftc8inx 7770 16 ) ) -RRB- cord-010092-uftc8inx 7770 17 . . . cord-010092-uftc8inx 7771 1 Among among IN cord-010092-uftc8inx 7771 2 OBI OBI NNP cord-010092-uftc8inx 7771 3 donors donor NNS cord-010092-uftc8inx 7771 4 , , , cord-010092-uftc8inx 7771 5 160 160 CD cord-010092-uftc8inx 7771 6 ( ( -LRB- cord-010092-uftc8inx 7771 7 54.5 54.5 CD cord-010092-uftc8inx 7771 8 % % NN cord-010092-uftc8inx 7771 9 ) ) -RRB- cord-010092-uftc8inx 7771 10 tested test VBD cord-010092-uftc8inx 7771 11 anti anti NNP cord-010092-uftc8inx 7771 12 - - NNP cord-010092-uftc8inx 7771 13 HBc+/anti HBc+/anti NNP cord-010092-uftc8inx 7771 14 - - HYPH cord-010092-uftc8inx 7771 15 HBs- HBs- NNP cord-010092-uftc8inx 7771 16 , , , cord-010092-uftc8inx 7771 17 108 108 CD cord-010092-uftc8inx 7771 18 ( ( -LRB- cord-010092-uftc8inx 7771 19 36.7 36.7 CD cord-010092-uftc8inx 7771 20 % % NN cord-010092-uftc8inx 7771 21 ) ) -RRB- cord-010092-uftc8inx 7771 22 were be VBD cord-010092-uftc8inx 7771 23 anti anti JJ cord-010092-uftc8inx 7771 24 - - JJ cord-010092-uftc8inx 7771 25 HBc+/anti HBc+/anti NNP cord-010092-uftc8inx 7771 26 - - HYPH cord-010092-uftc8inx 7771 27 HBs+ HBs+ NNP cord-010092-uftc8inx 7771 28 , , , cord-010092-uftc8inx 7771 29 25 25 CD cord-010092-uftc8inx 7771 30 ( ( -LRB- cord-010092-uftc8inx 7771 31 8.5 8.5 CD cord-010092-uftc8inx 7771 32 % % NN cord-010092-uftc8inx 7771 33 ) ) -RRB- cord-010092-uftc8inx 7772 1 were be VBD cord-010092-uftc8inx 7772 2 anti anti JJ cord-010092-uftc8inx 7772 3 - - JJ cord-010092-uftc8inx 7772 4 HBc-/anti HBc-/anti NNP cord-010092-uftc8inx 7772 5 - - HYPH cord-010092-uftc8inx 7772 6 HBs+ HBs+ NNP cord-010092-uftc8inx 7772 7 , , , cord-010092-uftc8inx 7772 8 and and CC cord-010092-uftc8inx 7772 9 1 1 CD cord-010092-uftc8inx 7772 10 anti anti JJ cord-010092-uftc8inx 7772 11 - - JJ cord-010092-uftc8inx 7772 12 HBc-/anti hbc-/anti JJ cord-010092-uftc8inx 7772 13 - - HYPH cord-010092-uftc8inx 7772 14 HBs hbs NN cord-010092-uftc8inx 7772 15 - - HYPH cord-010092-uftc8inx 7772 16 primary primary JJ cord-010092-uftc8inx 7772 17 OBI OBI NNP cord-010092-uftc8inx 7772 18 ( ( -LRB- cord-010092-uftc8inx 7772 19 0.3 0.3 CD cord-010092-uftc8inx 7772 20 % % NN cord-010092-uftc8inx 7772 21 ) ) -RRB- cord-010092-uftc8inx 7772 22 . . . cord-010092-uftc8inx 7773 1 Anti anti JJ cord-010092-uftc8inx 7773 2 - - NNP cord-010092-uftc8inx 7773 3 HBc-/anti HBc-/anti NNP cord-010092-uftc8inx 7773 4 - - HYPH cord-010092-uftc8inx 7773 5 HBs+ HBs+ NNP cord-010092-uftc8inx 7773 6 OBI OBI NNP cord-010092-uftc8inx 7773 7 donors donor NNS cord-010092-uftc8inx 7773 8 were be VBD cord-010092-uftc8inx 7773 9 significantly significantly RB cord-010092-uftc8inx 7773 10 younger young JJR cord-010092-uftc8inx 7773 11 ( ( -LRB- cord-010092-uftc8inx 7773 12 mean mean VB cord-010092-uftc8inx 7773 13 : : : cord-010092-uftc8inx 7774 1 21 21 CD cord-010092-uftc8inx 7774 2 years year NNS cord-010092-uftc8inx 7775 1 [ [ -LRB- cord-010092-uftc8inx 7775 2 range range NN cord-010092-uftc8inx 7775 3 : : : cord-010092-uftc8inx 7775 4 18 18 CD cord-010092-uftc8inx 7775 5 - - SYM cord-010092-uftc8inx 7775 6 57 57 CD cord-010092-uftc8inx 7775 7 years year NNS cord-010092-uftc8inx 7775 8 ] ] -RRB- cord-010092-uftc8inx 7775 9 ) ) -RRB- cord-010092-uftc8inx 7775 10 than than IN cord-010092-uftc8inx 7775 11 those those DT cord-010092-uftc8inx 7775 12 with with IN cord-010092-uftc8inx 7775 13 anti anti JJ cord-010092-uftc8inx 7775 14 - - JJ cord-010092-uftc8inx 7775 15 HBc+/anti HBc+/anti NNP cord-010092-uftc8inx 7775 16 - - HYPH cord-010092-uftc8inx 7775 17 HBs+ HBs+ NNP cord-010092-uftc8inx 7776 1 ( ( -LRB- cord-010092-uftc8inx 7776 2 mean mean VB cord-010092-uftc8inx 7776 3 : : : cord-010092-uftc8inx 7776 4 44 44 CD cord-010092-uftc8inx 7776 5 years year NNS cord-010092-uftc8inx 7777 1 [ [ -LRB- cord-010092-uftc8inx 7777 2 range range NN cord-010092-uftc8inx 7777 3 : : : cord-010092-uftc8inx 7777 4 19 19 CD cord-010092-uftc8inx 7777 5 - - SYM cord-010092-uftc8inx 7777 6 60 60 CD cord-010092-uftc8inx 7777 7 years year NNS cord-010092-uftc8inx 7777 8 ] ] -RRB- cord-010092-uftc8inx 7777 9 ) ) -RRB- cord-010092-uftc8inx 7777 10 and and CC cord-010092-uftc8inx 7777 11 anti anti JJ cord-010092-uftc8inx 7777 12 - - JJ cord-010092-uftc8inx 7777 13 HBc+/anti hbc+/anti JJ cord-010092-uftc8inx 7777 14 - - HYPH cord-010092-uftc8inx 7777 15 HBs-(median HBs-(median NNP cord-010092-uftc8inx 7777 16 : : : cord-010092-uftc8inx 7777 17 45 45 CD cord-010092-uftc8inx 7777 18 years year NNS cord-010092-uftc8inx 7778 1 [ [ -LRB- cord-010092-uftc8inx 7778 2 range range NN cord-010092-uftc8inx 7778 3 : : : cord-010092-uftc8inx 7778 4 21 21 CD cord-010092-uftc8inx 7778 5 - - SYM cord-010092-uftc8inx 7778 6 55 55 CD cord-010092-uftc8inx 7778 7 years year NNS cord-010092-uftc8inx 7778 8 ] ] -RRB- cord-010092-uftc8inx 7778 9 ) ) -RRB- cord-010092-uftc8inx 7778 10 profiles profile NNS cord-010092-uftc8inx 7778 11 ( ( -LRB- cord-010092-uftc8inx 7778 12 P p NN cord-010092-uftc8inx 7778 13 < < XX cord-010092-uftc8inx 7778 14 0.0001 0.0001 CD cord-010092-uftc8inx 7778 15 ) ) -RRB- cord-010092-uftc8inx 7778 16 . . . cord-010092-uftc8inx 7779 1 HBV HBV NNP cord-010092-uftc8inx 7779 2 vaccination vaccination NN cord-010092-uftc8inx 7779 3 was be VBD cord-010092-uftc8inx 7779 4 documented document VBN cord-010092-uftc8inx 7779 5 for for IN cord-010092-uftc8inx 7779 6 18 18 CD cord-010092-uftc8inx 7779 7 ( ( -LRB- cord-010092-uftc8inx 7779 8 72 72 CD cord-010092-uftc8inx 7779 9 % % NN cord-010092-uftc8inx 7779 10 ) ) -RRB- cord-010092-uftc8inx 7779 11 of of IN cord-010092-uftc8inx 7779 12 these these DT cord-010092-uftc8inx 7779 13 donors donor NNS cord-010092-uftc8inx 7779 14 and and CC cord-010092-uftc8inx 7779 15 was be VBD cord-010092-uftc8inx 7779 16 reported report VBN cord-010092-uftc8inx 7779 17 in in IN cord-010092-uftc8inx 7779 18 one one CD cord-010092-uftc8inx 7779 19 donor donor NN cord-010092-uftc8inx 7779 20 but but CC cord-010092-uftc8inx 7779 21 without without IN cord-010092-uftc8inx 7779 22 definitive definitive JJ cord-010092-uftc8inx 7779 23 evidence evidence NN cord-010092-uftc8inx 7779 24 . . . cord-010092-uftc8inx 7780 1 Extremely extremely RB cord-010092-uftc8inx 7780 2 low low JJ cord-010092-uftc8inx 7780 3 HBV HBV NNP cord-010092-uftc8inx 7780 4 DNA dna NN cord-010092-uftc8inx 7780 5 loads load NNS cord-010092-uftc8inx 7780 6 ( ( -LRB- cord-010092-uftc8inx 7780 7 range range NN cord-010092-uftc8inx 7780 8 : : : cord-010092-uftc8inx 7780 9 < < XX cord-010092-uftc8inx 7780 10 10 10 CD cord-010092-uftc8inx 7780 11 - - SYM cord-010092-uftc8inx 7780 12 155 155 CD cord-010092-uftc8inx 7780 13 IU IU NNP cord-010092-uftc8inx 7780 14 / / SYM cord-010092-uftc8inx 7780 15 mL ml NN cord-010092-uftc8inx 7780 16 ) ) -RRB- cord-010092-uftc8inx 7780 17 were be VBD cord-010092-uftc8inx 7780 18 transiently transiently RB cord-010092-uftc8inx 7780 19 detected detect VBN cord-010092-uftc8inx 7780 20 in in IN cord-010092-uftc8inx 7780 21 seven seven CD cord-010092-uftc8inx 7780 22 donors donor NNS cord-010092-uftc8inx 7780 23 during during IN cord-010092-uftc8inx 7780 24 follow follow VB cord-010092-uftc8inx 7780 25 up up RP cord-010092-uftc8inx 7780 26 . . . cord-010092-uftc8inx 7781 1 Genotypes genotypes NN cord-010092-uftc8inx 7781 2 identified identify VBD cord-010092-uftc8inx 7781 3 were be VBD cord-010092-uftc8inx 7781 4 genotype genotype NN cord-010092-uftc8inx 7781 5 B b NN cord-010092-uftc8inx 7781 6 ( ( -LRB- cord-010092-uftc8inx 7781 7 n n NN cord-010092-uftc8inx 7781 8 = = SYM cord-010092-uftc8inx 7781 9 1/20 1/20 CD cord-010092-uftc8inx 7781 10 ) ) -RRB- cord-010092-uftc8inx 7781 11 and and CC cord-010092-uftc8inx 7782 1 genotype genotype NNP cord-010092-uftc8inx 7782 2 C C NNP cord-010092-uftc8inx 7782 3 ( ( -LRB- cord-010092-uftc8inx 7782 4 n n NN cord-010092-uftc8inx 7782 5 = = SYM cord-010092-uftc8inx 7782 6 19/20 19/20 CD cord-010092-uftc8inx 7782 7 ) ) -RRB- cord-010092-uftc8inx 7782 8 . . . cord-010092-uftc8inx 7783 1 Preliminary preliminary JJ cord-010092-uftc8inx 7783 2 analysis analysis NN cord-010092-uftc8inx 7783 3 of of IN cord-010092-uftc8inx 7783 4 core core NN cord-010092-uftc8inx 7783 5 protein protein NN cord-010092-uftc8inx 7783 6 ( ( -LRB- cord-010092-uftc8inx 7783 7 n n NN cord-010092-uftc8inx 7783 8 = = SYM cord-010092-uftc8inx 7783 9 16 16 CD cord-010092-uftc8inx 7783 10 ) ) -RRB- cord-010092-uftc8inx 7783 11 and and CC cord-010092-uftc8inx 7783 12 BCP BCP NNP cord-010092-uftc8inx 7783 13 ( ( -LRB- cord-010092-uftc8inx 7783 14 n n NN cord-010092-uftc8inx 7783 15 = = SYM cord-010092-uftc8inx 7783 16 10 10 CD cord-010092-uftc8inx 7783 17 ) ) -RRB- cord-010092-uftc8inx 7783 18 sequences sequence NNS cord-010092-uftc8inx 7783 19 showed show VBD cord-010092-uftc8inx 7783 20 no no DT cord-010092-uftc8inx 7783 21 particular particular JJ cord-010092-uftc8inx 7783 22 genetic genetic JJ cord-010092-uftc8inx 7783 23 feature feature NN cord-010092-uftc8inx 7783 24 that that WDT cord-010092-uftc8inx 7783 25 could could MD cord-010092-uftc8inx 7783 26 be be VB cord-010092-uftc8inx 7783 27 associated associate VBN cord-010092-uftc8inx 7783 28 with with IN cord-010092-uftc8inx 7783 29 altered altered JJ cord-010092-uftc8inx 7783 30 antigenicity antigenicity NN cord-010092-uftc8inx 7783 31 or or CC cord-010092-uftc8inx 7783 32 core core NN cord-010092-uftc8inx 7783 33 gene gene NN cord-010092-uftc8inx 7783 34 expression expression NN cord-010092-uftc8inx 7783 35 . . . cord-010092-uftc8inx 7784 1 Follow follow VB cord-010092-uftc8inx 7784 2 - - HYPH cord-010092-uftc8inx 7784 3 up up NN cord-010092-uftc8inx 7784 4 was be VBD cord-010092-uftc8inx 7784 5 available available JJ cord-010092-uftc8inx 7784 6 for for IN cord-010092-uftc8inx 7784 7 15/ 15/ CD cord-010092-uftc8inx 7784 8 25 25 CD cord-010092-uftc8inx 7784 9 anti anti JJ cord-010092-uftc8inx 7784 10 - - JJ cord-010092-uftc8inx 7784 11 HBc-/anti HBc-/anti NNP cord-010092-uftc8inx 7784 12 - - HYPH cord-010092-uftc8inx 7784 13 HBs+ HBs+ NNP cord-010092-uftc8inx 7784 14 donors donor NNS cord-010092-uftc8inx 7784 15 ( ( -LRB- cord-010092-uftc8inx 7784 16 2 2 CD cord-010092-uftc8inx 7784 17 - - SYM cord-010092-uftc8inx 7784 18 6 6 CD cord-010092-uftc8inx 7784 19 samples sample NNS cord-010092-uftc8inx 7784 20 / / SYM cord-010092-uftc8inx 7784 21 donor donor NN cord-010092-uftc8inx 7784 22 ; ; : cord-010092-uftc8inx 7784 23 range range NN cord-010092-uftc8inx 7784 24 : : : cord-010092-uftc8inx 7784 25 2 2 CD cord-010092-uftc8inx 7784 26 - - SYM cord-010092-uftc8inx 7784 27 56 56 CD cord-010092-uftc8inx 7784 28 months month NNS cord-010092-uftc8inx 7784 29 ) ) -RRB- cord-010092-uftc8inx 7784 30 . . . cord-010092-uftc8inx 7785 1 Anti Anti NNP cord-010092-uftc8inx 7785 2 - - NNP cord-010092-uftc8inx 7785 3 HBc HBc NNP cord-010092-uftc8inx 7785 4 remained remain VBD cord-010092-uftc8inx 7785 5 undetectable undetectable JJ cord-010092-uftc8inx 7785 6 with with IN cord-010092-uftc8inx 7785 7 all all DT cord-010092-uftc8inx 7785 8 CLIA CLIA NNP cord-010092-uftc8inx 7785 9 assays assay NNS cord-010092-uftc8inx 7785 10 in in IN cord-010092-uftc8inx 7785 11 these these DT cord-010092-uftc8inx 7785 12 donors donor NNS cord-010092-uftc8inx 7785 13 except except IN cord-010092-uftc8inx 7785 14 one one CD cord-010092-uftc8inx 7785 15 . . . cord-010092-uftc8inx 7786 1 Low low RB cord-010092-uftc8inx 7786 2 transiently transiently RB cord-010092-uftc8inx 7786 3 detectable detectable JJ cord-010092-uftc8inx 7786 4 levels level NNS cord-010092-uftc8inx 7786 5 of of IN cord-010092-uftc8inx 7786 6 HBV HBV NNP cord-010092-uftc8inx 7786 7 DNA DNA NNP cord-010092-uftc8inx 7786 8 were be VBD cord-010092-uftc8inx 7786 9 observed observe VBN cord-010092-uftc8inx 7786 10 overtime overtime NN cord-010092-uftc8inx 7786 11 with with IN cord-010092-uftc8inx 7786 12 anti anti JJ cord-010092-uftc8inx 7786 13 - - JJ cord-010092-uftc8inx 7786 14 HBs hbs JJ cord-010092-uftc8inx 7786 15 levels level NNS cord-010092-uftc8inx 7786 16 fluctuating fluctuate VBG cord-010092-uftc8inx 7786 17 between between IN cord-010092-uftc8inx 7786 18 12 12 CD cord-010092-uftc8inx 7786 19 and and CC cord-010092-uftc8inx 7786 20 1,000 1,000 CD cord-010092-uftc8inx 7786 21 IU IU NNP cord-010092-uftc8inx 7786 22 / / SYM cord-010092-uftc8inx 7786 23 L. L. NNP cord-010092-uftc8inx 7786 24 no no DT cord-010092-uftc8inx 7786 25 significant significant JJ cord-010092-uftc8inx 7786 26 difference difference NN cord-010092-uftc8inx 7786 27 in in IN cord-010092-uftc8inx 7786 28 HLA HLA NNP cord-010092-uftc8inx 7786 29 - - HYPH cord-010092-uftc8inx 7786 30 A A NNP cord-010092-uftc8inx 7786 31 , , , cord-010092-uftc8inx 7786 32 -B -b ADD cord-010092-uftc8inx 7786 33 ( ( -LRB- cord-010092-uftc8inx 7786 34 except except IN cord-010092-uftc8inx 7786 35 HLA HLA NNP cord-010092-uftc8inx 7786 36 - - HYPH cord-010092-uftc8inx 7786 37 B*46 B*46 NNP cord-010092-uftc8inx 7786 38 more more RBR cord-010092-uftc8inx 7786 39 frequently frequently RB cord-010092-uftc8inx 7786 40 detected detect VBN cord-010092-uftc8inx 7786 41 in in IN cord-010092-uftc8inx 7786 42 anti anti JJ cord-010092-uftc8inx 7786 43 - - JJ cord-010092-uftc8inx 7786 44 HBc hbc JJ cord-010092-uftc8inx 7786 45 negative negative JJ cord-010092-uftc8inx 7786 46 OBI OBI NNP cord-010092-uftc8inx 7786 47 ) ) -RRB- cord-010092-uftc8inx 7786 48 , , , cord-010092-uftc8inx 7786 49 and and CC cord-010092-uftc8inx 7786 50 -DRB1 -drb1 NN cord-010092-uftc8inx 7787 1 * * NFP cord-010092-uftc8inx 7787 2 . . . cord-010092-uftc8inx 7788 1 Summary Summary NNP cord-010092-uftc8inx 7788 2 / / SYM cord-010092-uftc8inx 7788 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 7788 4 : : : cord-010092-uftc8inx 7789 1 Overall overall RB cord-010092-uftc8inx 7789 2 , , , cord-010092-uftc8inx 7789 3 the the DT cord-010092-uftc8inx 7789 4 8.5 8.5 CD cord-010092-uftc8inx 7789 5 % % NN cord-010092-uftc8inx 7789 6 prevalence prevalence NN cord-010092-uftc8inx 7789 7 of of IN cord-010092-uftc8inx 7789 8 anti anti JJ cord-010092-uftc8inx 7789 9 - - JJ cord-010092-uftc8inx 7789 10 HBs hbs JJ cord-010092-uftc8inx 7789 11 - - HYPH cord-010092-uftc8inx 7789 12 only only RB cord-010092-uftc8inx 7789 13 in in IN cord-010092-uftc8inx 7789 14 HBV HBV NNP cord-010092-uftc8inx 7789 15 DNA DNA NNP cord-010092-uftc8inx 7789 16 positive positive JJ cord-010092-uftc8inx 7789 17 OBI obi NN cord-010092-uftc8inx 7789 18 carriers carrier NNS cord-010092-uftc8inx 7789 19 ( ( -LRB- cord-010092-uftc8inx 7789 20 1:20,355 1:20,355 CD cord-010092-uftc8inx 7789 21 of of IN cord-010092-uftc8inx 7789 22 total total JJ cord-010092-uftc8inx 7789 23 donors donor NNS cord-010092-uftc8inx 7789 24 ) ) -RRB- cord-010092-uftc8inx 7789 25 in in IN cord-010092-uftc8inx 7789 26 Dalian Dalian NNP cord-010092-uftc8inx 7789 27 blood blood NN cord-010092-uftc8inx 7789 28 donors donor NNS cord-010092-uftc8inx 7789 29 confirmed confirm VBD cord-010092-uftc8inx 7789 30 previous previous JJ cord-010092-uftc8inx 7789 31 reports report NNS cord-010092-uftc8inx 7789 32 from from IN cord-010092-uftc8inx 7789 33 South South NNP cord-010092-uftc8inx 7789 34 East East NNP cord-010092-uftc8inx 7789 35 Asia Asia NNP cord-010092-uftc8inx 7789 36 . . . cord-010092-uftc8inx 7790 1 This this DT cord-010092-uftc8inx 7790 2 phenomenon phenomenon NN cord-010092-uftc8inx 7790 3 was be VBD cord-010092-uftc8inx 7790 4 not not RB cord-010092-uftc8inx 7790 5 related relate VBN cord-010092-uftc8inx 7790 6 to to IN cord-010092-uftc8inx 7790 7 Core core JJ cord-010092-uftc8inx 7790 8 antigenic antigenic JJ cord-010092-uftc8inx 7790 9 variations variation NNS cord-010092-uftc8inx 7790 10 but but CC cord-010092-uftc8inx 7790 11 was be VBD cord-010092-uftc8inx 7790 12 significantly significantly RB cord-010092-uftc8inx 7790 13 associated associate VBN cord-010092-uftc8inx 7790 14 with with IN cord-010092-uftc8inx 7790 15 younger young JJR cord-010092-uftc8inx 7790 16 age age NN cord-010092-uftc8inx 7790 17 of of IN cord-010092-uftc8inx 7790 18 carriers carrier NNS cord-010092-uftc8inx 7790 19 . . . cord-010092-uftc8inx 7791 1 A a DT cord-010092-uftc8inx 7791 2 particular particular JJ cord-010092-uftc8inx 7791 3 route route NN cord-010092-uftc8inx 7791 4 and and CC cord-010092-uftc8inx 7791 5 natural natural JJ cord-010092-uftc8inx 7791 6 history history NN cord-010092-uftc8inx 7791 7 of of IN cord-010092-uftc8inx 7791 8 the the DT cord-010092-uftc8inx 7791 9 infection infection NN cord-010092-uftc8inx 7791 10 may may MD cord-010092-uftc8inx 7791 11 be be VB cord-010092-uftc8inx 7791 12 considered consider VBN cord-010092-uftc8inx 7791 13 . . . cord-010092-uftc8inx 7792 1 The the DT cord-010092-uftc8inx 7792 2 hypothesis hypothesis NN cord-010092-uftc8inx 7792 3 of of IN cord-010092-uftc8inx 7792 4 acute acute JJ cord-010092-uftc8inx 7792 5 - - HYPH cord-010092-uftc8inx 7792 6 phase phase NN cord-010092-uftc8inx 7792 7 vaccine vaccine NN cord-010092-uftc8inx 7792 8 breakthrough breakthrough NN cord-010092-uftc8inx 7792 9 was be VBD cord-010092-uftc8inx 7792 10 ruled rule VBN cord-010092-uftc8inx 7792 11 out out RP cord-010092-uftc8inx 7792 12 in in IN cord-010092-uftc8inx 7792 13 15/25 15/25 CD cord-010092-uftc8inx 7792 14 donors donor NNS cord-010092-uftc8inx 7792 15 by by IN cord-010092-uftc8inx 7792 16 the the DT cord-010092-uftc8inx 7792 17 over over IN cord-010092-uftc8inx 7792 18 50 50 CD cord-010092-uftc8inx 7792 19 months month NNS cord-010092-uftc8inx 7792 20 stability stability NN cord-010092-uftc8inx 7792 21 of of IN cord-010092-uftc8inx 7792 22 this this DT cord-010092-uftc8inx 7792 23 serological serological JJ cord-010092-uftc8inx 7792 24 profile profile NN cord-010092-uftc8inx 7792 25 . . . cord-010092-uftc8inx 7793 1 Breakthrough Breakthrough NNP cord-010092-uftc8inx 7793 2 in in IN cord-010092-uftc8inx 7793 3 immunized immunize VBN cord-010092-uftc8inx 7793 4 donors donor NNS cord-010092-uftc8inx 7793 5 may may MD cord-010092-uftc8inx 7793 6 still still RB cord-010092-uftc8inx 7793 7 be be VB cord-010092-uftc8inx 7793 8 suspected suspect VBN cord-010092-uftc8inx 7793 9 . . . cord-010092-uftc8inx 7794 1 Further further JJ cord-010092-uftc8inx 7794 2 studies study NNS cord-010092-uftc8inx 7794 3 are be VBP cord-010092-uftc8inx 7794 4 needed need VBN cord-010092-uftc8inx 7794 5 to to TO cord-010092-uftc8inx 7794 6 evaluate evaluate VB cord-010092-uftc8inx 7794 7 the the DT cord-010092-uftc8inx 7794 8 potential potential JJ cord-010092-uftc8inx 7794 9 infectivity infectivity NN cord-010092-uftc8inx 7794 10 of of IN cord-010092-uftc8inx 7794 11 anti anti JJ cord-010092-uftc8inx 7794 12 - - JJ cord-010092-uftc8inx 7794 13 HBs hbs JJ cord-010092-uftc8inx 7794 14 - - HYPH cord-010092-uftc8inx 7794 15 only only RB cord-010092-uftc8inx 7794 16 / / SYM cord-010092-uftc8inx 7794 17 HBV HBV NNP cord-010092-uftc8inx 7794 18 DNA+ DNA+ NNP cord-010092-uftc8inx 7794 19 OBI OBI NNP cord-010092-uftc8inx 7794 20 carriers carrier NNS cord-010092-uftc8inx 7794 21 , , , cord-010092-uftc8inx 7794 22 and and CC cord-010092-uftc8inx 7794 23 to to TO cord-010092-uftc8inx 7794 24 characterize characterize VB cord-010092-uftc8inx 7794 25 the the DT cord-010092-uftc8inx 7794 26 potential potential JJ cord-010092-uftc8inx 7794 27 viral viral JJ cord-010092-uftc8inx 7794 28 and and CC cord-010092-uftc8inx 7794 29 immunological immunological JJ cord-010092-uftc8inx 7794 30 mechanisms mechanism NNS cord-010092-uftc8inx 7794 31 responsible responsible JJ cord-010092-uftc8inx 7794 32 for for IN cord-010092-uftc8inx 7794 33 this this DT cord-010092-uftc8inx 7794 34 unusual unusual JJ cord-010092-uftc8inx 7794 35 HBV HBV NNP cord-010092-uftc8inx 7794 36 infection infection NN cord-010092-uftc8inx 7794 37 profile profile NN cord-010092-uftc8inx 7794 38 . . . cord-010092-uftc8inx 7795 1 Confirmatory Confirmatory NNP cord-010092-uftc8inx 7795 2 Laboratory Laboratory NNP cord-010092-uftc8inx 7795 3 , , , cord-010092-uftc8inx 7795 4 Hungarian Hungarian NNP cord-010092-uftc8inx 7795 5 National National NNP cord-010092-uftc8inx 7795 6 Blood Blood NNP cord-010092-uftc8inx 7795 7 Transfusion Transfusion NNP cord-010092-uftc8inx 7795 8 Service Service NNP cord-010092-uftc8inx 7795 9 ( ( -LRB- cord-010092-uftc8inx 7795 10 HNBTS HNBTS NNP cord-010092-uftc8inx 7795 11 ) ) -RRB- cord-010092-uftc8inx 7795 12 , , , cord-010092-uftc8inx 7795 13 Budapest Budapest NNP cord-010092-uftc8inx 7795 14 , , , cord-010092-uftc8inx 7795 15 Hungary Hungary NNP cord-010092-uftc8inx 7795 16 Background Background NNP cord-010092-uftc8inx 7795 17 : : : cord-010092-uftc8inx 7795 18 Vaccination vaccination NN cord-010092-uftc8inx 7795 19 against against IN cord-010092-uftc8inx 7795 20 Hepatitis Hepatitis NNP cord-010092-uftc8inx 7795 21 B B NNP cord-010092-uftc8inx 7795 22 virus virus NN cord-010092-uftc8inx 7795 23 ( ( -LRB- cord-010092-uftc8inx 7795 24 HBV HBV NNP cord-010092-uftc8inx 7795 25 ) ) -RRB- cord-010092-uftc8inx 7795 26 is be VBZ cord-010092-uftc8inx 7795 27 an an DT cord-010092-uftc8inx 7795 28 effective effective JJ cord-010092-uftc8inx 7795 29 tool tool NN cord-010092-uftc8inx 7795 30 to to TO cord-010092-uftc8inx 7795 31 avoid avoid VB cord-010092-uftc8inx 7795 32 the the DT cord-010092-uftc8inx 7795 33 infection infection NN cord-010092-uftc8inx 7795 34 . . . cord-010092-uftc8inx 7796 1 In in IN cord-010092-uftc8inx 7796 2 Hungary Hungary NNP cord-010092-uftc8inx 7796 3 , , , cord-010092-uftc8inx 7796 4 population population NN cord-010092-uftc8inx 7796 5 born bear VBN cord-010092-uftc8inx 7796 6 after after IN cord-010092-uftc8inx 7796 7 1986 1986 CD cord-010092-uftc8inx 7796 8 is be VBZ cord-010092-uftc8inx 7796 9 considered consider VBN cord-010092-uftc8inx 7796 10 to to TO cord-010092-uftc8inx 7796 11 be be VB cord-010092-uftc8inx 7796 12 immunized immunize VBN cord-010092-uftc8inx 7796 13 , , , cord-010092-uftc8inx 7796 14 because because IN cord-010092-uftc8inx 7796 15 inoculation inoculation NN cord-010092-uftc8inx 7796 16 has have VBZ cord-010092-uftc8inx 7796 17 been be VBN cord-010092-uftc8inx 7796 18 mandatory mandatory JJ cord-010092-uftc8inx 7796 19 for for IN cord-010092-uftc8inx 7796 20 children child NNS cord-010092-uftc8inx 7796 21 as as IN cord-010092-uftc8inx 7796 22 campaign campaign NN cord-010092-uftc8inx 7796 23 vaccination vaccination NN cord-010092-uftc8inx 7796 24 since since IN cord-010092-uftc8inx 7796 25 2000 2000 CD cord-010092-uftc8inx 7796 26 . . . cord-010092-uftc8inx 7797 1 HBV HBV NNP cord-010092-uftc8inx 7797 2 vaccine vaccine NN cord-010092-uftc8inx 7797 3 is be VBZ cord-010092-uftc8inx 7797 4 strongly strongly RB cord-010092-uftc8inx 7797 5 recommended recommend VBN cord-010092-uftc8inx 7797 6 for for IN cord-010092-uftc8inx 7797 7 healthcare healthcare NN cord-010092-uftc8inx 7797 8 workers worker NNS cord-010092-uftc8inx 7797 9 , , , cord-010092-uftc8inx 7797 10 moreover moreover RB cord-010092-uftc8inx 7797 11 trips trip VBZ cord-010092-uftc8inx 7797 12 to to IN cord-010092-uftc8inx 7797 13 endemic endemic JJ cord-010092-uftc8inx 7797 14 countries country NNS cord-010092-uftc8inx 7797 15 and and CC cord-010092-uftc8inx 7797 16 awareness awareness NN cord-010092-uftc8inx 7797 17 of of IN cord-010092-uftc8inx 7797 18 individuals individual NNS cord-010092-uftc8inx 7797 19 could could MD cord-010092-uftc8inx 7797 20 also also RB cord-010092-uftc8inx 7797 21 be be VB cord-010092-uftc8inx 7797 22 reasons reason NNS cord-010092-uftc8inx 7797 23 of of IN cord-010092-uftc8inx 7797 24 vaccination vaccination NN cord-010092-uftc8inx 7797 25 in in IN cord-010092-uftc8inx 7797 26 immunologically immunologically RB cord-010092-uftc8inx 7797 27 na€ na€ JJ cord-010092-uftc8inx 7797 28 ıve ıve NN cord-010092-uftc8inx 7797 29 age age NN cord-010092-uftc8inx 7797 30 - - HYPH cord-010092-uftc8inx 7797 31 groups group NNS cord-010092-uftc8inx 7797 32 . . . cord-010092-uftc8inx 7798 1 Since since IN cord-010092-uftc8inx 7798 2 the the DT cord-010092-uftc8inx 7798 3 HBV HBV NNP cord-010092-uftc8inx 7798 4 vaccine vaccine NN cord-010092-uftc8inx 7798 5 contains contain VBZ cord-010092-uftc8inx 7798 6 surface surface NN cord-010092-uftc8inx 7798 7 antigen antigen NN cord-010092-uftc8inx 7798 8 , , , cord-010092-uftc8inx 7798 9 a a DT cord-010092-uftc8inx 7798 10 recent recent JJ cord-010092-uftc8inx 7798 11 inoculation inoculation NN cord-010092-uftc8inx 7798 12 can can MD cord-010092-uftc8inx 7798 13 cause cause VB cord-010092-uftc8inx 7798 14 reactivity reactivity NN cord-010092-uftc8inx 7798 15 of of IN cord-010092-uftc8inx 7798 16 HBsAg HBsAg NNP cord-010092-uftc8inx 7798 17 screening screen VBG cord-010092-uftc8inx 7798 18 assays assay NNS cord-010092-uftc8inx 7798 19 and and CC cord-010092-uftc8inx 7798 20 positivity positivity NN cord-010092-uftc8inx 7798 21 of of IN cord-010092-uftc8inx 7798 22 confirmatory confirmatory JJ cord-010092-uftc8inx 7798 23 tests test NNS cord-010092-uftc8inx 7798 24 for for IN cord-010092-uftc8inx 7798 25 several several JJ cord-010092-uftc8inx 7798 26 days day NNS cord-010092-uftc8inx 7798 27 resulting result VBG cord-010092-uftc8inx 7798 28 in in IN cord-010092-uftc8inx 7798 29 deferral deferral NN cord-010092-uftc8inx 7798 30 of of IN cord-010092-uftc8inx 7798 31 donors donor NNS cord-010092-uftc8inx 7798 32 from from IN cord-010092-uftc8inx 7798 33 blood blood NN cord-010092-uftc8inx 7798 34 donation donation NN cord-010092-uftc8inx 7798 35 . . . cord-010092-uftc8inx 7799 1 The the DT cord-010092-uftc8inx 7799 2 former former JJ cord-010092-uftc8inx 7799 3 regulation regulation NN cord-010092-uftc8inx 7799 4 of of IN cord-010092-uftc8inx 7799 5 HNBTS HNBTS NNP cord-010092-uftc8inx 7799 6 , , , cord-010092-uftc8inx 7799 7 which which WDT cord-010092-uftc8inx 7799 8 was be VBD cord-010092-uftc8inx 7799 9 valid valid JJ cord-010092-uftc8inx 7799 10 until until IN cord-010092-uftc8inx 7799 11 December December NNP cord-010092-uftc8inx 7799 12 31 31 CD cord-010092-uftc8inx 7799 13 , , , cord-010092-uftc8inx 7799 14 2018 2018 CD cord-010092-uftc8inx 7799 15 , , , cord-010092-uftc8inx 7799 16 allowed allow VBD cord-010092-uftc8inx 7799 17 the the DT cord-010092-uftc8inx 7799 18 re re NN cord-010092-uftc8inx 7799 19 - - NN cord-010092-uftc8inx 7799 20 entry entry NN cord-010092-uftc8inx 7799 21 of of IN cord-010092-uftc8inx 7799 22 donors donor NNS cord-010092-uftc8inx 7799 23 whose whose WP$ cord-010092-uftc8inx 7799 24 immunization immunization NN cord-010092-uftc8inx 7799 25 records record NNS cord-010092-uftc8inx 7799 26 and and CC cord-010092-uftc8inx 7799 27 negative negative JJ cord-010092-uftc8inx 7799 28 HBV HBV NNP cord-010092-uftc8inx 7799 29 confirmation confirmation NN cord-010092-uftc8inx 7799 30 of of IN cord-010092-uftc8inx 7799 31 the the DT cord-010092-uftc8inx 7799 32 second second JJ cord-010092-uftc8inx 7799 33 blood blood NN cord-010092-uftc8inx 7799 34 samples sample NNS cord-010092-uftc8inx 7799 35 proved prove VBD cord-010092-uftc8inx 7799 36 that that IN cord-010092-uftc8inx 7799 37 the the DT cord-010092-uftc8inx 7799 38 previous previous JJ cord-010092-uftc8inx 7799 39 vaccination vaccination NN cord-010092-uftc8inx 7799 40 had have VBD cord-010092-uftc8inx 7799 41 resulted result VBN cord-010092-uftc8inx 7799 42 in in IN cord-010092-uftc8inx 7799 43 the the DT cord-010092-uftc8inx 7799 44 HBsAg HBsAg NNP cord-010092-uftc8inx 7799 45 confirmed confirm VBD cord-010092-uftc8inx 7799 46 positivity positivity NN cord-010092-uftc8inx 7799 47 . . . cord-010092-uftc8inx 7800 1 Aims aim VBZ cord-010092-uftc8inx 7800 2 : : : cord-010092-uftc8inx 7801 1 The the DT cord-010092-uftc8inx 7801 2 aim aim NN cord-010092-uftc8inx 7801 3 of of IN cord-010092-uftc8inx 7801 4 this this DT cord-010092-uftc8inx 7801 5 study study NN cord-010092-uftc8inx 7801 6 was be VBD cord-010092-uftc8inx 7801 7 to to TO cord-010092-uftc8inx 7801 8 strengthen strengthen VB cord-010092-uftc8inx 7801 9 that that DT cord-010092-uftc8inx 7801 10 vaccination vaccination NN cord-010092-uftc8inx 7801 11 against against IN cord-010092-uftc8inx 7801 12 HBV HBV NNP cord-010092-uftc8inx 7801 13 before before IN cord-010092-uftc8inx 7801 14 blood blood NN cord-010092-uftc8inx 7801 15 donation donation NN cord-010092-uftc8inx 7801 16 had have VBD cord-010092-uftc8inx 7801 17 resulted result VBN cord-010092-uftc8inx 7801 18 in in IN cord-010092-uftc8inx 7801 19 the the DT cord-010092-uftc8inx 7801 20 reactivity reactivity NN cord-010092-uftc8inx 7801 21 of of IN cord-010092-uftc8inx 7801 22 HBsAg HBsAg NNP cord-010092-uftc8inx 7801 23 screening screening NN cord-010092-uftc8inx 7801 24 and and CC cord-010092-uftc8inx 7801 25 confirmatory confirmatory JJ cord-010092-uftc8inx 7801 26 assays assay NNS cord-010092-uftc8inx 7801 27 between between IN cord-010092-uftc8inx 7801 28 2012 2012 CD cord-010092-uftc8inx 7801 29 and and CC cord-010092-uftc8inx 7801 30 2018 2018 CD cord-010092-uftc8inx 7801 31 . . . cord-010092-uftc8inx 7802 1 Background background NN cord-010092-uftc8inx 7802 2 : : : cord-010092-uftc8inx 7803 1 In in IN cord-010092-uftc8inx 7803 2 Brazil Brazil NNP cord-010092-uftc8inx 7803 3 , , , cord-010092-uftc8inx 7803 4 the the DT cord-010092-uftc8inx 7803 5 introduction introduction NN cord-010092-uftc8inx 7803 6 of of IN cord-010092-uftc8inx 7803 7 nucleic nucleic JJ cord-010092-uftc8inx 7803 8 acid acid NN cord-010092-uftc8inx 7803 9 tests test NNS cord-010092-uftc8inx 7803 10 ( ( -LRB- cord-010092-uftc8inx 7803 11 NAT NAT NNP cord-010092-uftc8inx 7803 12 ) ) -RRB- cord-010092-uftc8inx 7803 13 for for IN cord-010092-uftc8inx 7803 14 HBV HBV NNP cord-010092-uftc8inx 7803 15 - - HYPH cord-010092-uftc8inx 7803 16 DNA dna NN cord-010092-uftc8inx 7803 17 detection detection NN cord-010092-uftc8inx 7803 18 in in IN cord-010092-uftc8inx 7803 19 the the DT cord-010092-uftc8inx 7803 20 routine routine JJ cord-010092-uftc8inx 7803 21 screening screening NN cord-010092-uftc8inx 7803 22 at at IN cord-010092-uftc8inx 7803 23 public public JJ cord-010092-uftc8inx 7803 24 blood blood NN cord-010092-uftc8inx 7803 25 banks bank NNS cord-010092-uftc8inx 7803 26 is be VBZ cord-010092-uftc8inx 7803 27 relatively relatively RB cord-010092-uftc8inx 7803 28 recent recent JJ cord-010092-uftc8inx 7803 29 . . . cord-010092-uftc8inx 7804 1 At at IN cord-010092-uftc8inx 7804 2 Fundac Fundac NNP cord-010092-uftc8inx 7804 3 ßão ßão NNP cord-010092-uftc8inx 7805 1 Pr Pr NNP cord-010092-uftc8inx 7805 2 o o NNP cord-010092-uftc8inx 7805 3 - - HYPH cord-010092-uftc8inx 7805 4 Sangue Sangue NNP cord-010092-uftc8inx 7805 5 / / SYM cord-010092-uftc8inx 7805 6 Hemocentro Hemocentro NNP cord-010092-uftc8inx 7805 7 de de NNP cord-010092-uftc8inx 7805 8 São São NNP cord-010092-uftc8inx 7805 9 Paulo Paulo NNP cord-010092-uftc8inx 7805 10 ( ( -LRB- cord-010092-uftc8inx 7805 11 FPS FPS NNP cord-010092-uftc8inx 7805 12 - - HYPH cord-010092-uftc8inx 7805 13 SP SP NNP cord-010092-uftc8inx 7805 14 ) ) -RRB- cord-010092-uftc8inx 7805 15 , , , cord-010092-uftc8inx 7805 16 about about RB cord-010092-uftc8inx 7805 17 130,000 130,000 CD cord-010092-uftc8inx 7805 18 blood blood NN cord-010092-uftc8inx 7805 19 donors donor NNS cord-010092-uftc8inx 7805 20 are be VBP cord-010092-uftc8inx 7805 21 submitted submit VBN cord-010092-uftc8inx 7805 22 to to IN cord-010092-uftc8inx 7805 23 serological serological JJ cord-010092-uftc8inx 7805 24 screening screening NN cord-010092-uftc8inx 7805 25 tests test NNS cord-010092-uftc8inx 7805 26 ( ( -LRB- cord-010092-uftc8inx 7805 27 HBV HBV NNP cord-010092-uftc8inx 7805 28 , , , cord-010092-uftc8inx 7805 29 HCV HCV NNP cord-010092-uftc8inx 7805 30 , , , cord-010092-uftc8inx 7805 31 HIV-1/2 HIV-1/2 NNP cord-010092-uftc8inx 7805 32 , , , cord-010092-uftc8inx 7805 33 Chagas Chagas NNP cord-010092-uftc8inx 7805 34 disease disease NN cord-010092-uftc8inx 7805 35 , , , cord-010092-uftc8inx 7805 36 Syphilis Syphilis NNP cord-010092-uftc8inx 7805 37 and and CC cord-010092-uftc8inx 7805 38 HTLV-1/2 HTLV-1/2 NNP cord-010092-uftc8inx 7805 39 ) ) -RRB- cord-010092-uftc8inx 7805 40 and and CC cord-010092-uftc8inx 7805 41 NAT NAT NNP cord-010092-uftc8inx 7805 42 for for IN cord-010092-uftc8inx 7805 43 HIV HIV NNP cord-010092-uftc8inx 7805 44 , , , cord-010092-uftc8inx 7805 45 HCV HCV NNP cord-010092-uftc8inx 7805 46 and and CC cord-010092-uftc8inx 7805 47 HBV HBV NNP cord-010092-uftc8inx 7805 48 per per IN cord-010092-uftc8inx 7805 49 year year NN cord-010092-uftc8inx 7805 50 . . . cord-010092-uftc8inx 7806 1 Approximately approximately RB cord-010092-uftc8inx 7806 2 2 2 CD cord-010092-uftc8inx 7806 3 % % NN cord-010092-uftc8inx 7806 4 of of IN cord-010092-uftc8inx 7806 5 the the DT cord-010092-uftc8inx 7806 6 blood blood NN cord-010092-uftc8inx 7806 7 donations donation NNS cord-010092-uftc8inx 7806 8 are be VBP cord-010092-uftc8inx 7806 9 discarded discard VBN cord-010092-uftc8inx 7806 10 due due IN cord-010092-uftc8inx 7806 11 to to IN cord-010092-uftc8inx 7806 12 some some DT cord-010092-uftc8inx 7806 13 reactive reactive JJ cord-010092-uftc8inx 7806 14 result result NN cord-010092-uftc8inx 7806 15 ; ; : cord-010092-uftc8inx 7806 16 of of IN cord-010092-uftc8inx 7806 17 these these DT cord-010092-uftc8inx 7806 18 , , , cord-010092-uftc8inx 7806 19 the the DT cord-010092-uftc8inx 7806 20 HBV HBV NNP cord-010092-uftc8inx 7806 21 discard discard VBP cord-010092-uftc8inx 7806 22 rate rate NN cord-010092-uftc8inx 7806 23 was be VBD cord-010092-uftc8inx 7806 24 0.65 0.65 CD cord-010092-uftc8inx 7806 25 % % NN cord-010092-uftc8inx 7806 26 in in IN cord-010092-uftc8inx 7806 27 2016 2016 CD cord-010092-uftc8inx 7806 28 . . . cord-010092-uftc8inx 7807 1 Aims aim VBZ cord-010092-uftc8inx 7807 2 : : : cord-010092-uftc8inx 7808 1 Our -PRON- PRP$ cord-010092-uftc8inx 7808 2 study study NN cord-010092-uftc8inx 7808 3 aims aim VBZ cord-010092-uftc8inx 7808 4 to to TO cord-010092-uftc8inx 7808 5 determine determine VB cord-010092-uftc8inx 7808 6 the the DT cord-010092-uftc8inx 7808 7 potential potential JJ cord-010092-uftc8inx 7808 8 infectious infectious JJ cord-010092-uftc8inx 7808 9 cases case NNS cord-010092-uftc8inx 7808 10 among among IN cord-010092-uftc8inx 7808 11 samples sample NNS cord-010092-uftc8inx 7808 12 that that WDT cord-010092-uftc8inx 7808 13 had have VBD cord-010092-uftc8inx 7808 14 one one CD cord-010092-uftc8inx 7808 15 or or CC cord-010092-uftc8inx 7808 16 more more JJR cord-010092-uftc8inx 7808 17 HBV HBV NNP cord-010092-uftc8inx 7808 18 - - HYPH cord-010092-uftc8inx 7808 19 reactive reactive JJ cord-010092-uftc8inx 7808 20 screening screening NN cord-010092-uftc8inx 7808 21 results result NNS cord-010092-uftc8inx 7808 22 ( ( -LRB- cord-010092-uftc8inx 7808 23 anti anti JJ cord-010092-uftc8inx 7808 24 - - JJ cord-010092-uftc8inx 7808 25 HBc hbc JJ cord-010092-uftc8inx 7808 26 , , , cord-010092-uftc8inx 7808 27 HBsAg HBsAg NNP cord-010092-uftc8inx 7808 28 and and CC cord-010092-uftc8inx 7808 29 MP MP NNP cord-010092-uftc8inx 7808 30 - - HYPH cord-010092-uftc8inx 7808 31 NAT NAT NNP cord-010092-uftc8inx 7808 32 - - HYPH cord-010092-uftc8inx 7808 33 HBV HBV NNP cord-010092-uftc8inx 7808 34 ) ) -RRB- cord-010092-uftc8inx 7808 35 and and CC cord-010092-uftc8inx 7808 36 verify verify VB cord-010092-uftc8inx 7808 37 the the DT cord-010092-uftc8inx 7808 38 different different JJ cord-010092-uftc8inx 7808 39 categories category NNS cord-010092-uftc8inx 7808 40 of of IN cord-010092-uftc8inx 7808 41 HBV HBV NNP cord-010092-uftc8inx 7808 42 infection infection NN cord-010092-uftc8inx 7808 43 ( ( -LRB- cord-010092-uftc8inx 7808 44 acute acute JJ cord-010092-uftc8inx 7808 45 , , , cord-010092-uftc8inx 7808 46 chronic chronic JJ cord-010092-uftc8inx 7808 47 , , , cord-010092-uftc8inx 7808 48 Occult Occult NNP cord-010092-uftc8inx 7808 49 hepatitis hepatitis NN cord-010092-uftc8inx 7808 50 B B NNP cord-010092-uftc8inx 7808 51 Infection infection NN cord-010092-uftc8inx 7808 52 ( ( -LRB- cord-010092-uftc8inx 7808 53 OBI OBI NNP cord-010092-uftc8inx 7808 54 ) ) -RRB- cord-010092-uftc8inx 7808 55 and and CC cord-010092-uftc8inx 7808 56 immunological immunological JJ cord-010092-uftc8inx 7808 57 window window NN cord-010092-uftc8inx 7808 58 ) ) -RRB- cord-010092-uftc8inx 7808 59 . . . cord-010092-uftc8inx 7809 1 Furthermore furthermore RB cord-010092-uftc8inx 7809 2 , , , cord-010092-uftc8inx 7809 3 to to TO cord-010092-uftc8inx 7809 4 characterize characterize VB cord-010092-uftc8inx 7809 5 the the DT cord-010092-uftc8inx 7809 6 distribution distribution NN cord-010092-uftc8inx 7809 7 of of IN cord-010092-uftc8inx 7809 8 HBV HBV NNP cord-010092-uftc8inx 7809 9 genotypes genotype NNS cord-010092-uftc8inx 7809 10 , , , cord-010092-uftc8inx 7809 11 drug drug NN cord-010092-uftc8inx 7809 12 resistance resistance NN cord-010092-uftc8inx 7809 13 and and CC cord-010092-uftc8inx 7809 14 escape escape NN cord-010092-uftc8inx 7809 15 mutations mutation NNS cord-010092-uftc8inx 7809 16 and and CC cord-010092-uftc8inx 7809 17 analyze analyze VB cord-010092-uftc8inx 7809 18 the the DT cord-010092-uftc8inx 7809 19 risk risk NN cord-010092-uftc8inx 7809 20 factors factor NNS cord-010092-uftc8inx 7809 21 . . . cord-010092-uftc8inx 7810 1 Methods method NNS cord-010092-uftc8inx 7810 2 : : : cord-010092-uftc8inx 7810 3 We -PRON- PRP cord-010092-uftc8inx 7810 4 carried carry VBD cord-010092-uftc8inx 7810 5 out out RP cord-010092-uftc8inx 7810 6 a a DT cord-010092-uftc8inx 7810 7 cross cross JJ cord-010092-uftc8inx 7810 8 - - JJ cord-010092-uftc8inx 7810 9 sectional sectional JJ cord-010092-uftc8inx 7810 10 study study NN cord-010092-uftc8inx 7810 11 of of IN cord-010092-uftc8inx 7810 12 roughly roughly RB cord-010092-uftc8inx 7810 13 74,000 74,000 CD cord-010092-uftc8inx 7810 14 donations donation NNS cord-010092-uftc8inx 7810 15 from from IN cord-010092-uftc8inx 7810 16 May May NNP cord-010092-uftc8inx 7810 17 2016 2016 CD cord-010092-uftc8inx 7810 18 to to IN cord-010092-uftc8inx 7810 19 December December NNP cord-010092-uftc8inx 7810 20 2016 2016 CD cord-010092-uftc8inx 7810 21 . . . cord-010092-uftc8inx 7811 1 HBV HBV NNP cord-010092-uftc8inx 7811 2 antibodies antibody NNS cord-010092-uftc8inx 7811 3 and and CC cord-010092-uftc8inx 7811 4 antigen antigen NN cord-010092-uftc8inx 7811 5 screening screening NN cord-010092-uftc8inx 7811 6 were be VBD cord-010092-uftc8inx 7811 7 performed perform VBN cord-010092-uftc8inx 7811 8 using use VBG cord-010092-uftc8inx 7811 9 CMIA CMIA NNP cord-010092-uftc8inx 7811 10 kits kit NNS cord-010092-uftc8inx 7811 11 Architect architect NN cord-010092-uftc8inx 7812 1 â â LS cord-010092-uftc8inx 7812 2 -Abbott -Abbott NNP cord-010092-uftc8inx 7812 3 / / SYM cord-010092-uftc8inx 7812 4 HBsAg hbsag ADD cord-010092-uftc8inx 7812 5 and and CC cord-010092-uftc8inx 7812 6 Architect Architect NNP cord-010092-uftc8inx 7812 7 â â . cord-010092-uftc8inx 7813 1 -Abbott -Abbott NNP cord-010092-uftc8inx 7813 2 / / SYM cord-010092-uftc8inx 7813 3 anti anti JJ cord-010092-uftc8inx 7813 4 - - JJ cord-010092-uftc8inx 7813 5 HBc hbc JJ cord-010092-uftc8inx 7813 6 . . . cord-010092-uftc8inx 7814 1 NAT NAT NNP cord-010092-uftc8inx 7814 2 screening screening NN cord-010092-uftc8inx 7814 3 was be VBD cord-010092-uftc8inx 7814 4 performed perform VBN cord-010092-uftc8inx 7814 5 in in IN cord-010092-uftc8inx 7814 6 minipools minipools NNP cord-010092-uftc8inx 7814 7 ( ( -LRB- cord-010092-uftc8inx 7814 8 MP MP NNP cord-010092-uftc8inx 7814 9 ) ) -RRB- cord-010092-uftc8inx 7814 10 of of IN cord-010092-uftc8inx 7814 11 six six CD cord-010092-uftc8inx 7814 12 samples sample NNS cord-010092-uftc8inx 7814 13 using use VBG cord-010092-uftc8inx 7814 14 Kit Kit NNP cord-010092-uftc8inx 7814 15 NAT NAT NNP cord-010092-uftc8inx 7814 16 HIV HIV NNP cord-010092-uftc8inx 7814 17 / / SYM cord-010092-uftc8inx 7814 18 HCV/ HCV/ NNP cord-010092-uftc8inx 7814 19 HBV HBV NNP cord-010092-uftc8inx 7814 20 -Bio -Bio NNPS cord-010092-uftc8inx 7814 21 - - : cord-010092-uftc8inx 7814 22 Manguinhos Manguinhos NNP cord-010092-uftc8inx 7814 23 ( ( -LRB- cord-010092-uftc8inx 7814 24 sensitivity sensitivity NN cord-010092-uftc8inx 7814 25 95 95 CD cord-010092-uftc8inx 7814 26 % % NN cord-010092-uftc8inx 7814 27 LOD lod NN cord-010092-uftc8inx 7814 28 300 300 CD cord-010092-uftc8inx 7814 29 IU IU NNP cord-010092-uftc8inx 7814 30 / / , cord-010092-uftc8inx 7814 31 mL ml NN cord-010092-uftc8inx 7814 32 for for IN cord-010092-uftc8inx 7814 33 HBV HBV NNP cord-010092-uftc8inx 7814 34 ) ) -RRB- cord-010092-uftc8inx 7814 35 . . . cord-010092-uftc8inx 7815 1 Reagent reagent NN cord-010092-uftc8inx 7815 2 samples sample NNS cord-010092-uftc8inx 7815 3 ( ( -LRB- cord-010092-uftc8inx 7815 4 n n NN cord-010092-uftc8inx 7815 5 = = SYM cord-010092-uftc8inx 7815 6 407 407 CD cord-010092-uftc8inx 7815 7 ) ) -RRB- cord-010092-uftc8inx 7815 8 that that WDT cord-010092-uftc8inx 7815 9 presented present VBD cord-010092-uftc8inx 7815 10 one one CD cord-010092-uftc8inx 7815 11 or or CC cord-010092-uftc8inx 7815 12 more more JJR cord-010092-uftc8inx 7815 13 HBV HBV NNP cord-010092-uftc8inx 7815 14 - - HYPH cord-010092-uftc8inx 7815 15 reactive reactive JJ cord-010092-uftc8inx 7815 16 screening screening NN cord-010092-uftc8inx 7815 17 results result NNS cord-010092-uftc8inx 7815 18 ( ( -LRB- cord-010092-uftc8inx 7815 19 anti anti JJ cord-010092-uftc8inx 7815 20 - - JJ cord-010092-uftc8inx 7815 21 HBc hbc JJ cord-010092-uftc8inx 7815 22 , , , cord-010092-uftc8inx 7815 23 HBsAg HBsAg NNP cord-010092-uftc8inx 7815 24 and/or and/or CC cord-010092-uftc8inx 7815 25 MP MP NNP cord-010092-uftc8inx 7815 26 - - HYPH cord-010092-uftc8inx 7815 27 NAT NAT NNP cord-010092-uftc8inx 7815 28 - - HYPH cord-010092-uftc8inx 7815 29 HBV HBV NNP cord-010092-uftc8inx 7815 30 ) ) -RRB- cord-010092-uftc8inx 7815 31 , , , cord-010092-uftc8inx 7815 32 were be VBD cord-010092-uftc8inx 7815 33 submitted submit VBN cord-010092-uftc8inx 7815 34 to to IN cord-010092-uftc8inx 7815 35 individual individual JJ cord-010092-uftc8inx 7815 36 nucleic nucleic JJ cord-010092-uftc8inx 7815 37 acid acid NN cord-010092-uftc8inx 7815 38 extraction extraction NN cord-010092-uftc8inx 7815 39 and and CC cord-010092-uftc8inx 7815 40 " " `` cord-010092-uftc8inx 7815 41 in in IN cord-010092-uftc8inx 7815 42 house house NN cord-010092-uftc8inx 7815 43 " " '' cord-010092-uftc8inx 7815 44 quantitative quantitative JJ cord-010092-uftc8inx 7815 45 real real JJ cord-010092-uftc8inx 7815 46 - - HYPH cord-010092-uftc8inx 7815 47 time time NN cord-010092-uftc8inx 7815 48 PCR PCR NNP cord-010092-uftc8inx 7815 49 - - HYPH cord-010092-uftc8inx 7815 50 HBV HBV NNP cord-010092-uftc8inx 7815 51 ( ( -LRB- cord-010092-uftc8inx 7815 52 ID ID NNP cord-010092-uftc8inx 7815 53 - - HYPH cord-010092-uftc8inx 7815 54 PCR PCR NNP cord-010092-uftc8inx 7815 55 - - HYPH cord-010092-uftc8inx 7815 56 HBV HBV NNP cord-010092-uftc8inx 7815 57 ) ) -RRB- cord-010092-uftc8inx 7815 58 targeting target VBG cord-010092-uftc8inx 7815 59 the the DT cord-010092-uftc8inx 7815 60 HBsAg hbsag CD cord-010092-uftc8inx 7815 61 region region NN cord-010092-uftc8inx 7815 62 ( ( -LRB- cord-010092-uftc8inx 7815 63 sensitivity sensitivity NN cord-010092-uftc8inx 7815 64 10 10 CD cord-010092-uftc8inx 7815 65 - - SYM cord-010092-uftc8inx 7815 66 20 20 CD cord-010092-uftc8inx 7815 67 UI UI NNP cord-010092-uftc8inx 7815 68 / / SYM cord-010092-uftc8inx 7815 69 mL ml NN cord-010092-uftc8inx 7815 70 ) ) -RRB- cord-010092-uftc8inx 7815 71 . . . cord-010092-uftc8inx 7816 1 The the DT cord-010092-uftc8inx 7816 2 HBV HBV NNP cord-010092-uftc8inx 7816 3 genotypes genotype NNS cord-010092-uftc8inx 7816 4 and and CC cord-010092-uftc8inx 7816 5 mutation mutation NN cord-010092-uftc8inx 7816 6 analyses analysis NNS cord-010092-uftc8inx 7816 7 were be VBD cord-010092-uftc8inx 7816 8 determined determine VBN cord-010092-uftc8inx 7816 9 by by IN cord-010092-uftc8inx 7816 10 direct direct JJ cord-010092-uftc8inx 7816 11 sequencing sequencing NN cord-010092-uftc8inx 7816 12 of of IN cord-010092-uftc8inx 7816 13 the the DT cord-010092-uftc8inx 7816 14 HBV HBV NNP cord-010092-uftc8inx 7816 15 pol pol NN cord-010092-uftc8inx 7816 16 - - HYPH cord-010092-uftc8inx 7816 17 gene gene NN cord-010092-uftc8inx 7816 18 / / SYM cord-010092-uftc8inx 7816 19 surface surface NN cord-010092-uftc8inx 7816 20 - - HYPH cord-010092-uftc8inx 7816 21 gene gene NN cord-010092-uftc8inx 7816 22 and and CC cord-010092-uftc8inx 7816 23 use use NN cord-010092-uftc8inx 7816 24 of of IN cord-010092-uftc8inx 7816 25 the the DT cord-010092-uftc8inx 7816 26 online online JJ cord-010092-uftc8inx 7816 27 analysis analysis NN cord-010092-uftc8inx 7816 28 tool tool NN cord-010092-uftc8inx 7816 29 Geno2pheno Geno2pheno NNP cord-010092-uftc8inx 7817 1 [ [ -LRB- cord-010092-uftc8inx 7817 2 hbv hbv NNP cord-010092-uftc8inx 7817 3 ] ] -RRB- cord-010092-uftc8inx 7817 4 2.0 2.0 CD cord-010092-uftc8inx 7817 5 . . . cord-010092-uftc8inx 7818 1 Socio socio JJ cord-010092-uftc8inx 7818 2 - - HYPH cord-010092-uftc8inx 7818 3 demographic demographic JJ cord-010092-uftc8inx 7818 4 and and CC cord-010092-uftc8inx 7818 5 epidemiological epidemiological JJ cord-010092-uftc8inx 7818 6 data datum NNS cord-010092-uftc8inx 7818 7 were be VBD cord-010092-uftc8inx 7818 8 also also RB cord-010092-uftc8inx 7818 9 analyzed analyze VBN cord-010092-uftc8inx 7818 10 . . . cord-010092-uftc8inx 7819 1 Financial financial JJ cord-010092-uftc8inx 7819 2 support support NN cord-010092-uftc8inx 7819 3 : : : cord-010092-uftc8inx 7819 4 FAPESP FAPESP NNP cord-010092-uftc8inx 7819 5 2017/16658 2017/16658 CD cord-010092-uftc8inx 7819 6 - - SYM cord-010092-uftc8inx 7819 7 6 6 CD cord-010092-uftc8inx 7819 8 . . . cord-010092-uftc8inx 7820 1 Results result NNS cord-010092-uftc8inx 7820 2 : : : cord-010092-uftc8inx 7821 1 Among among IN cord-010092-uftc8inx 7821 2 the the DT cord-010092-uftc8inx 7821 3 407 407 CD cord-010092-uftc8inx 7821 4 HBV HBV NNP cord-010092-uftc8inx 7821 5 reactive reactive JJ cord-010092-uftc8inx 7821 6 samples sample NNS cord-010092-uftc8inx 7821 7 , , , cord-010092-uftc8inx 7821 8 377 377 CD cord-010092-uftc8inx 7821 9 were be VBD cord-010092-uftc8inx 7821 10 reactive reactive JJ cord-010092-uftc8inx 7821 11 for for IN cord-010092-uftc8inx 7821 12 anti anti JJ cord-010092-uftc8inx 7821 13 - - JJ cord-010092-uftc8inx 7821 14 HBc hbc JJ cord-010092-uftc8inx 7821 15 only only RB cord-010092-uftc8inx 7821 16 ( ( -LRB- cord-010092-uftc8inx 7821 17 92.6 92.6 CD cord-010092-uftc8inx 7821 18 % % NN cord-010092-uftc8inx 7821 19 ) ) -RRB- cord-010092-uftc8inx 7821 20 , , , cord-010092-uftc8inx 7821 21 10 10 CD cord-010092-uftc8inx 7821 22 for for IN cord-010092-uftc8inx 7821 23 HBsAg hbsag ADD cord-010092-uftc8inx 7821 24 only only RB cord-010092-uftc8inx 7821 25 ( ( -LRB- cord-010092-uftc8inx 7821 26 2.5 2.5 CD cord-010092-uftc8inx 7821 27 % % NN cord-010092-uftc8inx 7821 28 ) ) -RRB- cord-010092-uftc8inx 7821 29 and and CC cord-010092-uftc8inx 7821 30 20 20 CD cord-010092-uftc8inx 7821 31 were be VBD cord-010092-uftc8inx 7821 32 reactive reactive JJ cord-010092-uftc8inx 7821 33 for for IN cord-010092-uftc8inx 7821 34 both both DT cord-010092-uftc8inx 7821 35 markers marker NNS cord-010092-uftc8inx 7821 36 and and CC cord-010092-uftc8inx 7821 37 HBV HBV NNP cord-010092-uftc8inx 7821 38 DNA DNA NNP cord-010092-uftc8inx 7821 39 ( ( -LRB- cord-010092-uftc8inx 7821 40 4.9 4.9 CD cord-010092-uftc8inx 7821 41 % % NN cord-010092-uftc8inx 7821 42 ) ) -RRB- cord-010092-uftc8inx 7821 43 . . . cord-010092-uftc8inx 7822 1 Routine routine JJ cord-010092-uftc8inx 7822 2 testing testing NN cord-010092-uftc8inx 7822 3 and and CC cord-010092-uftc8inx 7822 4 ID ID NNP cord-010092-uftc8inx 7822 5 - - HYPH cord-010092-uftc8inx 7822 6 PCR PCR NNP cord-010092-uftc8inx 7822 7 - - HYPH cord-010092-uftc8inx 7822 8 HBV HBV NNP cord-010092-uftc8inx 7822 9 identified identify VBD cord-010092-uftc8inx 7822 10 20 20 CD cord-010092-uftc8inx 7822 11 ( ( -LRB- cord-010092-uftc8inx 7822 12 0.027 0.027 CD cord-010092-uftc8inx 7822 13 % % NN cord-010092-uftc8inx 7822 14 ) ) -RRB- cord-010092-uftc8inx 7822 15 samples sample NNS cord-010092-uftc8inx 7822 16 of of IN cord-010092-uftc8inx 7822 17 active active JJ cord-010092-uftc8inx 7822 18 infections infection NNS cord-010092-uftc8inx 7822 19 that that WDT cord-010092-uftc8inx 7822 20 had have VBD cord-010092-uftc8inx 7822 21 all all DT cord-010092-uftc8inx 7822 22 HBV HBV NNP cord-010092-uftc8inx 7822 23 reactive reactive JJ cord-010092-uftc8inx 7822 24 / / SYM cord-010092-uftc8inx 7822 25 positive positive JJ cord-010092-uftc8inx 7822 26 tests test NNS cord-010092-uftc8inx 7822 27 results result NNS cord-010092-uftc8inx 7822 28 . . . cord-010092-uftc8inx 7823 1 No no DT cord-010092-uftc8inx 7823 2 HBV HBV NNP cord-010092-uftc8inx 7823 3 DNAyield dnayield VBP cord-010092-uftc8inx 7823 4 samples sample NNS cord-010092-uftc8inx 7823 5 or or CC cord-010092-uftc8inx 7823 6 HBsAgyield hbsagyield NN cord-010092-uftc8inx 7823 7 or or CC cord-010092-uftc8inx 7823 8 OBI OBI NNP cord-010092-uftc8inx 7823 9 were be VBD cord-010092-uftc8inx 7823 10 observed observe VBN cord-010092-uftc8inx 7823 11 . . . cord-010092-uftc8inx 7824 1 Viral viral JJ cord-010092-uftc8inx 7824 2 loads load NNS cord-010092-uftc8inx 7824 3 for for IN cord-010092-uftc8inx 7824 4 active active JJ cord-010092-uftc8inx 7824 5 infections infection NNS cord-010092-uftc8inx 7824 6 samples sample NNS cord-010092-uftc8inx 7824 7 ranged range VBD cord-010092-uftc8inx 7824 8 from from IN cord-010092-uftc8inx 7824 9 1.08E+01 1.08e+01 CD cord-010092-uftc8inx 7824 10 to to IN cord-010092-uftc8inx 7824 11 2.45E+09 2.45e+09 CD cord-010092-uftc8inx 7824 12 cop cop NN cord-010092-uftc8inx 7824 13 / / SYM cord-010092-uftc8inx 7824 14 mL ml NN cord-010092-uftc8inx 7824 15 ( ( -LRB- cord-010092-uftc8inx 7824 16 median median NN cord-010092-uftc8inx 7824 17 , , , cord-010092-uftc8inx 7824 18 2.12E+08cop 2.12e+08cop CD cord-010092-uftc8inx 7824 19 / / SYM cord-010092-uftc8inx 7824 20 mL ml NN cord-010092-uftc8inx 7824 21 ) ) -RRB- cord-010092-uftc8inx 7824 22 . . . cord-010092-uftc8inx 7825 1 HBV HBV NNP cord-010092-uftc8inx 7825 2 sub sub NN cord-010092-uftc8inx 7825 3 - - HYPH cord-010092-uftc8inx 7825 4 genotypes genotype NNS cord-010092-uftc8inx 7825 5 A1 A1 NNP cord-010092-uftc8inx 7825 6 , , , cord-010092-uftc8inx 7825 7 A2 A2 NNP cord-010092-uftc8inx 7825 8 , , , cord-010092-uftc8inx 7825 9 C1 C1 NNP cord-010092-uftc8inx 7825 10 , , , cord-010092-uftc8inx 7825 11 D3 D3 NNP cord-010092-uftc8inx 7825 12 and and CC cord-010092-uftc8inx 7825 13 F1 F1 NNP cord-010092-uftc8inx 7825 14 were be VBD cord-010092-uftc8inx 7825 15 found find VBN cord-010092-uftc8inx 7825 16 in in IN cord-010092-uftc8inx 7825 17 70 70 CD cord-010092-uftc8inx 7825 18 % % NN cord-010092-uftc8inx 7825 19 , , , cord-010092-uftc8inx 7825 20 5 5 CD cord-010092-uftc8inx 7825 21 % % NN cord-010092-uftc8inx 7825 22 , , , cord-010092-uftc8inx 7825 23 5 5 CD cord-010092-uftc8inx 7825 24 % % NN cord-010092-uftc8inx 7825 25 , , , cord-010092-uftc8inx 7825 26 15 15 CD cord-010092-uftc8inx 7825 27 % % NN cord-010092-uftc8inx 7825 28 , , , cord-010092-uftc8inx 7825 29 and and CC cord-010092-uftc8inx 7825 30 5 5 CD cord-010092-uftc8inx 7825 31 % % NN cord-010092-uftc8inx 7825 32 of of IN cord-010092-uftc8inx 7825 33 the the DT cord-010092-uftc8inx 7825 34 donors donor NNS cord-010092-uftc8inx 7825 35 , , , cord-010092-uftc8inx 7825 36 respectively respectively RB cord-010092-uftc8inx 7825 37 . . . cord-010092-uftc8inx 7826 1 No no DT cord-010092-uftc8inx 7826 2 reverse reverse JJ cord-010092-uftc8inx 7826 3 transcriptase transcriptase NN cord-010092-uftc8inx 7826 4 inhibitor inhibitor NN cord-010092-uftc8inx 7826 5 - - HYPH cord-010092-uftc8inx 7826 6 resistant resistant JJ cord-010092-uftc8inx 7826 7 variants variant NNS cord-010092-uftc8inx 7826 8 were be VBD cord-010092-uftc8inx 7826 9 detected detect VBN cord-010092-uftc8inx 7826 10 . . . cord-010092-uftc8inx 7827 1 Escape escape NN cord-010092-uftc8inx 7827 2 mutations mutation NNS cord-010092-uftc8inx 7827 3 in in IN cord-010092-uftc8inx 7827 4 small small JJ cord-010092-uftc8inx 7827 5 HBsAg HBsAg NNP cord-010092-uftc8inx 7827 6 protein protein NN cord-010092-uftc8inx 7827 7 SHB SHB NNP cord-010092-uftc8inx 7827 8 region region NN cord-010092-uftc8inx 7827 9 were be VBD cord-010092-uftc8inx 7827 10 detected detect VBN cord-010092-uftc8inx 7827 11 in in IN cord-010092-uftc8inx 7827 12 30 30 CD cord-010092-uftc8inx 7827 13 % % NN cord-010092-uftc8inx 7827 14 ( ( -LRB- cord-010092-uftc8inx 7827 15 6/20 6/20 CD cord-010092-uftc8inx 7827 16 ) ) -RRB- cord-010092-uftc8inx 7827 17 , , , cord-010092-uftc8inx 7827 18 with with IN cord-010092-uftc8inx 7827 19 the the DT cord-010092-uftc8inx 7827 20 following follow VBG cord-010092-uftc8inx 7827 21 main main JJ cord-010092-uftc8inx 7827 22 substitutions substitution NNS cord-010092-uftc8inx 7827 23 100C 100c NN cord-010092-uftc8inx 7827 24 ( ( -LRB- cord-010092-uftc8inx 7827 25 3x 3x CD cord-010092-uftc8inx 7827 26 ) ) -RRB- cord-010092-uftc8inx 7827 27 , , , cord-010092-uftc8inx 7827 28 120R 120r CD cord-010092-uftc8inx 7827 29 , , , cord-010092-uftc8inx 7827 30 123N 123n CD cord-010092-uftc8inx 7827 31 and and CC cord-010092-uftc8inx 7827 32 144G. 144G. NNP cord-010092-uftc8inx 7828 1 The the DT cord-010092-uftc8inx 7828 2 mean mean JJ cord-010092-uftc8inx 7828 3 age age NN cord-010092-uftc8inx 7828 4 of of IN cord-010092-uftc8inx 7828 5 donors donor NNS cord-010092-uftc8inx 7828 6 with with IN cord-010092-uftc8inx 7828 7 active active JJ cord-010092-uftc8inx 7828 8 HBV HBV NNP cord-010092-uftc8inx 7828 9 infection infection NN cord-010092-uftc8inx 7828 10 was be VBD cord-010092-uftc8inx 7828 11 40 40 CD cord-010092-uftc8inx 7828 12 years year NNS cord-010092-uftc8inx 7828 13 , , , cord-010092-uftc8inx 7828 14 mostly mostly RB cord-010092-uftc8inx 7828 15 donors donor NNS cord-010092-uftc8inx 7828 16 were be VBD cord-010092-uftc8inx 7828 17 males male NNS cord-010092-uftc8inx 7828 18 ( ( -LRB- cord-010092-uftc8inx 7828 19 80 80 CD cord-010092-uftc8inx 7828 20 % % NN cord-010092-uftc8inx 7828 21 ) ) -RRB- cord-010092-uftc8inx 7828 22 , , , cord-010092-uftc8inx 7828 23 mixed mix VBN cord-010092-uftc8inx 7828 24 ( ( -LRB- cord-010092-uftc8inx 7828 25 40 40 CD cord-010092-uftc8inx 7828 26 % % NN cord-010092-uftc8inx 7828 27 ) ) -RRB- cord-010092-uftc8inx 7828 28 or or CC cord-010092-uftc8inx 7828 29 white white JJ cord-010092-uftc8inx 7828 30 ( ( -LRB- cord-010092-uftc8inx 7828 31 40 40 CD cord-010092-uftc8inx 7828 32 % % NN cord-010092-uftc8inx 7828 33 ) ) -RRB- cord-010092-uftc8inx 7828 34 and and CC cord-010092-uftc8inx 7828 35 had have VBD cord-010092-uftc8inx 7828 36 concluded conclude VBN cord-010092-uftc8inx 7828 37 high high JJ cord-010092-uftc8inx 7828 38 school school NN cord-010092-uftc8inx 7828 39 ( ( -LRB- cord-010092-uftc8inx 7828 40 45 45 CD cord-010092-uftc8inx 7828 41 % % NN cord-010092-uftc8inx 7828 42 ) ) -RRB- cord-010092-uftc8inx 7828 43 . . . cord-010092-uftc8inx 7829 1 Summary Summary NNP cord-010092-uftc8inx 7829 2 / / SYM cord-010092-uftc8inx 7829 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 7829 4 : : : cord-010092-uftc8inx 7829 5 Discard discard VB cord-010092-uftc8inx 7829 6 rate rate NN cord-010092-uftc8inx 7829 7 due due IN cord-010092-uftc8inx 7829 8 to to IN cord-010092-uftc8inx 7829 9 isolated isolated JJ cord-010092-uftc8inx 7829 10 anti anti JJ cord-010092-uftc8inx 7829 11 - - JJ cord-010092-uftc8inx 7829 12 HBc HBc NNP cord-010092-uftc8inx 7829 13 is be VBZ cord-010092-uftc8inx 7829 14 high high JJ cord-010092-uftc8inx 7829 15 but but CC cord-010092-uftc8inx 7829 16 no no DT cord-010092-uftc8inx 7829 17 OBI obi NN cord-010092-uftc8inx 7829 18 was be VBD cord-010092-uftc8inx 7829 19 found find VBN cord-010092-uftc8inx 7829 20 in in IN cord-010092-uftc8inx 7829 21 the the DT cord-010092-uftc8inx 7829 22 blood blood NN cord-010092-uftc8inx 7829 23 donor donor NN cord-010092-uftc8inx 7829 24 population population NN cord-010092-uftc8inx 7829 25 studied study VBD cord-010092-uftc8inx 7829 26 . . . cord-010092-uftc8inx 7830 1 In in IN cord-010092-uftc8inx 7830 2 addition addition NN cord-010092-uftc8inx 7830 3 , , , cord-010092-uftc8inx 7830 4 no no DT cord-010092-uftc8inx 7830 5 case case NN cord-010092-uftc8inx 7830 6 of of IN cord-010092-uftc8inx 7830 7 immunological immunological JJ cord-010092-uftc8inx 7830 8 window window NN cord-010092-uftc8inx 7830 9 for for IN cord-010092-uftc8inx 7830 10 HBV HBV NNP cord-010092-uftc8inx 7830 11 or or CC cord-010092-uftc8inx 7830 12 HBsAgyield HBsAgyield NNP cord-010092-uftc8inx 7830 13 was be VBD cord-010092-uftc8inx 7830 14 detected detect VBN cord-010092-uftc8inx 7830 15 . . . cord-010092-uftc8inx 7831 1 There there EX cord-010092-uftc8inx 7831 2 was be VBD cord-010092-uftc8inx 7831 3 a a DT cord-010092-uftc8inx 7831 4 predominance predominance NN cord-010092-uftc8inx 7831 5 of of IN cord-010092-uftc8inx 7831 6 subgenotype subgenotype NNP cord-010092-uftc8inx 7831 7 A1 A1 NNP cord-010092-uftc8inx 7831 8 and and CC cord-010092-uftc8inx 7831 9 mutations mutation NNS cord-010092-uftc8inx 7831 10 associated associate VBN cord-010092-uftc8inx 7831 11 with with IN cord-010092-uftc8inx 7831 12 escape escape NN cord-010092-uftc8inx 7831 13 were be VBD cord-010092-uftc8inx 7831 14 found find VBN cord-010092-uftc8inx 7831 15 in in IN cord-010092-uftc8inx 7831 16 30 30 CD cord-010092-uftc8inx 7831 17 % % NN cord-010092-uftc8inx 7831 18 of of IN cord-010092-uftc8inx 7831 19 HBV HBV NNP cord-010092-uftc8inx 7831 20 - - HYPH cord-010092-uftc8inx 7831 21 DNApositive dnapositive JJ cord-010092-uftc8inx 7831 22 samples sample NNS cord-010092-uftc8inx 7831 23 . . . cord-010092-uftc8inx 7832 1 Continuous continuous JJ cord-010092-uftc8inx 7832 2 research research NN cord-010092-uftc8inx 7832 3 and and CC cord-010092-uftc8inx 7832 4 surveillance surveillance NN cord-010092-uftc8inx 7832 5 about about IN cord-010092-uftc8inx 7832 6 HBV HBV NNP cord-010092-uftc8inx 7832 7 prevalence prevalence NN cord-010092-uftc8inx 7832 8 among among IN cord-010092-uftc8inx 7832 9 blood blood NN cord-010092-uftc8inx 7832 10 donors donor NNS cord-010092-uftc8inx 7832 11 are be VBP cord-010092-uftc8inx 7832 12 needed need VBN cord-010092-uftc8inx 7832 13 to to TO cord-010092-uftc8inx 7832 14 maintain maintain VB cord-010092-uftc8inx 7832 15 and and CC cord-010092-uftc8inx 7832 16 evenly evenly RB cord-010092-uftc8inx 7832 17 increase increase VB cord-010092-uftc8inx 7832 18 blood blood NN cord-010092-uftc8inx 7832 19 safety safety NN cord-010092-uftc8inx 7832 20 in in IN cord-010092-uftc8inx 7832 21 Brazil Brazil NNP cord-010092-uftc8inx 7832 22 . . . cord-010092-uftc8inx 7833 1 Background background NN cord-010092-uftc8inx 7833 2 : : : cord-010092-uftc8inx 7834 1 Screening screen VBG cord-010092-uftc8inx 7834 2 for for IN cord-010092-uftc8inx 7834 3 anti anti JJ cord-010092-uftc8inx 7834 4 - - JJ cord-010092-uftc8inx 7834 5 HBcore hbcore JJ cord-010092-uftc8inx 7834 6 antibodies antibody NNS cord-010092-uftc8inx 7834 7 in in IN cord-010092-uftc8inx 7834 8 blood blood NN cord-010092-uftc8inx 7834 9 donors donor NNS cord-010092-uftc8inx 7834 10 is be VBZ cord-010092-uftc8inx 7834 11 considered consider VBN cord-010092-uftc8inx 7834 12 to to TO cord-010092-uftc8inx 7834 13 contribute contribute VB cord-010092-uftc8inx 7834 14 significantly significantly RB cord-010092-uftc8inx 7834 15 to to IN cord-010092-uftc8inx 7834 16 blood blood NN cord-010092-uftc8inx 7834 17 safety safety NN cord-010092-uftc8inx 7834 18 , , , cord-010092-uftc8inx 7834 19 since since IN cord-010092-uftc8inx 7834 20 it -PRON- PRP cord-010092-uftc8inx 7834 21 reveals reveal VBZ cord-010092-uftc8inx 7834 22 donors donor NNS cord-010092-uftc8inx 7834 23 with with IN cord-010092-uftc8inx 7834 24 occult occult JJ cord-010092-uftc8inx 7834 25 or or CC cord-010092-uftc8inx 7834 26 probable probable JJ cord-010092-uftc8inx 7834 27 occult occult JJ cord-010092-uftc8inx 7834 28 hepatitis hepatitis NN cord-010092-uftc8inx 7834 29 B B NNP cord-010092-uftc8inx 7834 30 , , , cord-010092-uftc8inx 7834 31 with with IN cord-010092-uftc8inx 7834 32 variable variable JJ cord-010092-uftc8inx 7834 33 results result NNS cord-010092-uftc8inx 7834 34 in in IN cord-010092-uftc8inx 7834 35 molecular molecular JJ cord-010092-uftc8inx 7834 36 screening screening NN cord-010092-uftc8inx 7834 37 , , , cord-010092-uftc8inx 7834 38 due due IN cord-010092-uftc8inx 7834 39 to to IN cord-010092-uftc8inx 7834 40 very very RB cord-010092-uftc8inx 7834 41 low low JJ cord-010092-uftc8inx 7834 42 viral viral JJ cord-010092-uftc8inx 7834 43 load load NN cord-010092-uftc8inx 7834 44 . . . cord-010092-uftc8inx 7835 1 However however RB cord-010092-uftc8inx 7835 2 , , , cord-010092-uftc8inx 7835 3 universal universal JJ cord-010092-uftc8inx 7835 4 anti anti JJ cord-010092-uftc8inx 7835 5 - - JJ cord-010092-uftc8inx 7835 6 HBcore hbcore JJ cord-010092-uftc8inx 7835 7 testing testing NN cord-010092-uftc8inx 7835 8 in in IN cord-010092-uftc8inx 7835 9 blood blood NN cord-010092-uftc8inx 7835 10 donors donor NNS cord-010092-uftc8inx 7835 11 , , , cord-010092-uftc8inx 7835 12 might may MD cord-010092-uftc8inx 7835 13 exclude exclude VB cord-010092-uftc8inx 7835 14 a a DT cord-010092-uftc8inx 7835 15 considerable considerable JJ cord-010092-uftc8inx 7835 16 number number NN cord-010092-uftc8inx 7835 17 of of IN cord-010092-uftc8inx 7835 18 blood blood NN cord-010092-uftc8inx 7835 19 donors donor NNS cord-010092-uftc8inx 7835 20 in in IN cord-010092-uftc8inx 7835 21 countries country NNS cord-010092-uftc8inx 7835 22 with with IN cord-010092-uftc8inx 7835 23 high high JJ cord-010092-uftc8inx 7835 24 HBV HBV NNP cord-010092-uftc8inx 7835 25 prevalence prevalence NN cord-010092-uftc8inx 7835 26 and and CC cord-010092-uftc8inx 7835 27 even even RB cord-010092-uftc8inx 7835 28 in in IN cord-010092-uftc8inx 7835 29 countries country NNS cord-010092-uftc8inx 7835 30 with with IN cord-010092-uftc8inx 7835 31 low low JJ cord-010092-uftc8inx 7835 32 to to IN cord-010092-uftc8inx 7835 33 moderate moderate JJ cord-010092-uftc8inx 7835 34 prevalence prevalence NN cord-010092-uftc8inx 7835 35 , , , cord-010092-uftc8inx 7835 36 like like IN cord-010092-uftc8inx 7835 37 Greece Greece NNP cord-010092-uftc8inx 7835 38 . . . cord-010092-uftc8inx 7836 1 Aims aim VBZ cord-010092-uftc8inx 7836 2 : : : cord-010092-uftc8inx 7837 1 The the DT cord-010092-uftc8inx 7837 2 aim aim NN cord-010092-uftc8inx 7837 3 was be VBD cord-010092-uftc8inx 7837 4 to to TO cord-010092-uftc8inx 7837 5 investigate investigate VB cord-010092-uftc8inx 7837 6 the the DT cord-010092-uftc8inx 7837 7 percentage percentage NN cord-010092-uftc8inx 7837 8 of of IN cord-010092-uftc8inx 7837 9 blood blood NN cord-010092-uftc8inx 7837 10 donors donor NNS cord-010092-uftc8inx 7837 11 with with IN cord-010092-uftc8inx 7837 12 natural natural JJ cord-010092-uftc8inx 7837 13 HBV HBV NNP cord-010092-uftc8inx 7837 14 infection infection NN cord-010092-uftc8inx 7837 15 ( ( -LRB- cord-010092-uftc8inx 7837 16 confirmed confirm VBD cord-010092-uftc8inx 7837 17 positive positive JJ cord-010092-uftc8inx 7837 18 anti anti JJ cord-010092-uftc8inx 7837 19 - - JJ cord-010092-uftc8inx 7837 20 HBcore hbcore JJ cord-010092-uftc8inx 7837 21 ) ) -RRB- cord-010092-uftc8inx 7837 22 or or CC cord-010092-uftc8inx 7837 23 HBV HBV NNP cord-010092-uftc8inx 7837 24 immunization immunization NN cord-010092-uftc8inx 7837 25 due due IN cord-010092-uftc8inx 7837 26 to to IN cord-010092-uftc8inx 7837 27 vaccination vaccination NN cord-010092-uftc8inx 7837 28 ( ( -LRB- cord-010092-uftc8inx 7837 29 anti anti NNP cord-010092-uftc8inx 7837 30 - - JJ cord-010092-uftc8inx 7837 31 HBs+ HBs+ NNP cord-010092-uftc8inx 7837 32 only only RB cord-010092-uftc8inx 7837 33 , , , cord-010092-uftc8inx 7837 34 due due IN cord-010092-uftc8inx 7837 35 to to IN cord-010092-uftc8inx 7837 36 vaccination vaccination NN cord-010092-uftc8inx 7837 37 ) ) -RRB- cord-010092-uftc8inx 7837 38 and and CC cord-010092-uftc8inx 7837 39 predict predict VB cord-010092-uftc8inx 7837 40 the the DT cord-010092-uftc8inx 7837 41 impact impact NN cord-010092-uftc8inx 7837 42 of of IN cord-010092-uftc8inx 7837 43 generalized generalized JJ cord-010092-uftc8inx 7837 44 anti anti JJ cord-010092-uftc8inx 7837 45 - - JJ cord-010092-uftc8inx 7837 46 HBcore hbcore JJ cord-010092-uftc8inx 7837 47 testing testing NN cord-010092-uftc8inx 7837 48 . . . cord-010092-uftc8inx 7838 1 Methods method NNS cord-010092-uftc8inx 7838 2 : : : cord-010092-uftc8inx 7838 3 During during IN cord-010092-uftc8inx 7838 4 the the DT cord-010092-uftc8inx 7838 5 period period NN cord-010092-uftc8inx 7838 6 15 15 CD cord-010092-uftc8inx 7838 7 - - SYM cord-010092-uftc8inx 7838 8 30 30 CD cord-010092-uftc8inx 7838 9 November November NNP cord-010092-uftc8inx 7838 10 2018 2018 CD cord-010092-uftc8inx 7838 11 , , , cord-010092-uftc8inx 7838 12 all all DT cord-010092-uftc8inx 7838 13 blood blood NN cord-010092-uftc8inx 7838 14 donors donor NNS cord-010092-uftc8inx 7838 15 were be VBD cord-010092-uftc8inx 7838 16 asked ask VBN cord-010092-uftc8inx 7838 17 to to TO cord-010092-uftc8inx 7838 18 give give VB cord-010092-uftc8inx 7838 19 their -PRON- PRP$ cord-010092-uftc8inx 7838 20 consensus consensus NN cord-010092-uftc8inx 7838 21 for for IN cord-010092-uftc8inx 7838 22 additional additional JJ cord-010092-uftc8inx 7838 23 screening screening NN cord-010092-uftc8inx 7838 24 for for IN cord-010092-uftc8inx 7838 25 hepatitis hepatitis NN cord-010092-uftc8inx 7838 26 B B NNP cord-010092-uftc8inx 7838 27 anti anti NNP cord-010092-uftc8inx 7838 28 - - JJ cord-010092-uftc8inx 7838 29 HBcore hbcore JJ cord-010092-uftc8inx 7838 30 and and CC cord-010092-uftc8inx 7838 31 anti anti JJ cord-010092-uftc8inx 7838 32 - - JJ cord-010092-uftc8inx 7838 33 HBs hbs JJ cord-010092-uftc8inx 7838 34 antibodies antibody NNS cord-010092-uftc8inx 7838 35 , , , cord-010092-uftc8inx 7838 36 besides besides IN cord-010092-uftc8inx 7838 37 the the DT cord-010092-uftc8inx 7838 38 obligatory obligatory JJ cord-010092-uftc8inx 7838 39 serological serological JJ cord-010092-uftc8inx 7838 40 and and CC cord-010092-uftc8inx 7838 41 molecular molecular JJ cord-010092-uftc8inx 7838 42 screening screening NN cord-010092-uftc8inx 7838 43 , , , cord-010092-uftc8inx 7839 1 The the DT cord-010092-uftc8inx 7839 2 samples sample NNS cord-010092-uftc8inx 7839 3 of of IN cord-010092-uftc8inx 7839 4 few few JJ cord-010092-uftc8inx 7839 5 donors donor NNS cord-010092-uftc8inx 7839 6 who who WP cord-010092-uftc8inx 7839 7 disagreed disagree VBD cord-010092-uftc8inx 7839 8 , , , cord-010092-uftc8inx 7839 9 were be VBD cord-010092-uftc8inx 7839 10 not not RB cord-010092-uftc8inx 7839 11 examined examine VBN cord-010092-uftc8inx 7839 12 . . . cord-010092-uftc8inx 7840 1 All all DT cord-010092-uftc8inx 7840 2 samples sample NNS cord-010092-uftc8inx 7840 3 with with IN cord-010092-uftc8inx 7840 4 repeated repeat VBN cord-010092-uftc8inx 7840 5 positive positive JJ cord-010092-uftc8inx 7840 6 anti anti JJ cord-010092-uftc8inx 7840 7 - - JJ cord-010092-uftc8inx 7840 8 HBcore hbcore JJ cord-010092-uftc8inx 7840 9 results result NNS cord-010092-uftc8inx 7840 10 , , , cord-010092-uftc8inx 7840 11 were be VBD cord-010092-uftc8inx 7840 12 further further RB cord-010092-uftc8inx 7840 13 examined examine VBN cord-010092-uftc8inx 7840 14 for for IN cord-010092-uftc8inx 7840 15 anti anti JJ cord-010092-uftc8inx 7840 16 - - JJ cord-010092-uftc8inx 7840 17 HBcore hbcore JJ cord-010092-uftc8inx 7840 18 IgM igm NN cord-010092-uftc8inx 7840 19 and and CC cord-010092-uftc8inx 7840 20 anti anti JJ cord-010092-uftc8inx 7840 21 - - JJ cord-010092-uftc8inx 7840 22 HBe hbe JJ cord-010092-uftc8inx 7840 23 antibodies antibody NNS cord-010092-uftc8inx 7840 24 . . . cord-010092-uftc8inx 7841 1 Furthermore furthermore RB cord-010092-uftc8inx 7841 2 , , , cord-010092-uftc8inx 7841 3 a a DT cord-010092-uftc8inx 7841 4 new new JJ cord-010092-uftc8inx 7841 5 donor donor NN cord-010092-uftc8inx 7841 6 sample sample NN cord-010092-uftc8inx 7841 7 was be VBD cord-010092-uftc8inx 7841 8 requested request VBN cord-010092-uftc8inx 7841 9 , , , cord-010092-uftc8inx 7841 10 to to TO cord-010092-uftc8inx 7841 11 confirm confirm VB cord-010092-uftc8inx 7841 12 reactivity reactivity NN cord-010092-uftc8inx 7841 13 . . . cord-010092-uftc8inx 7842 1 The the DT cord-010092-uftc8inx 7842 2 serology serology NN cord-010092-uftc8inx 7842 3 results result NNS cord-010092-uftc8inx 7842 4 were be VBD cord-010092-uftc8inx 7842 5 recorded record VBN cord-010092-uftc8inx 7842 6 in in IN cord-010092-uftc8inx 7842 7 an an DT cord-010092-uftc8inx 7842 8 excel excel JJ cord-010092-uftc8inx 7842 9 spreadsheet spreadsheet NN cord-010092-uftc8inx 7842 10 . . . cord-010092-uftc8inx 7843 1 Additional additional JJ cord-010092-uftc8inx 7843 2 data datum NNS cord-010092-uftc8inx 7843 3 , , , cord-010092-uftc8inx 7843 4 including include VBG cord-010092-uftc8inx 7843 5 age age NN cord-010092-uftc8inx 7843 6 , , , cord-010092-uftc8inx 7843 7 sex sex NN cord-010092-uftc8inx 7843 8 , , , cord-010092-uftc8inx 7843 9 nationality nationality NN cord-010092-uftc8inx 7843 10 , , , cord-010092-uftc8inx 7843 11 number number NN cord-010092-uftc8inx 7843 12 of of IN cord-010092-uftc8inx 7843 13 previous previous JJ cord-010092-uftc8inx 7843 14 blood blood NN cord-010092-uftc8inx 7843 15 donations donation NNS cord-010092-uftc8inx 7843 16 , , , cord-010092-uftc8inx 7843 17 ABO ABO NNP cord-010092-uftc8inx 7843 18 blood blood NN cord-010092-uftc8inx 7843 19 group group NN cord-010092-uftc8inx 7843 20 , , , cord-010092-uftc8inx 7843 21 family family NN cord-010092-uftc8inx 7843 22 history history NN cord-010092-uftc8inx 7843 23 of of IN cord-010092-uftc8inx 7843 24 HBV HBV NNP cord-010092-uftc8inx 7843 25 infection infection NN cord-010092-uftc8inx 7843 26 , , , cord-010092-uftc8inx 7843 27 HBV HBV NNP cord-010092-uftc8inx 7843 28 vaccination vaccination NN cord-010092-uftc8inx 7843 29 , , , cord-010092-uftc8inx 7843 30 were be VBD cord-010092-uftc8inx 7843 31 also also RB cord-010092-uftc8inx 7843 32 recorded record VBN cord-010092-uftc8inx 7843 33 and and CC cord-010092-uftc8inx 7843 34 statistically statistically RB cord-010092-uftc8inx 7843 35 evaluated evaluate VBN cord-010092-uftc8inx 7843 36 . . . cord-010092-uftc8inx 7844 1 Donors donor NNS cord-010092-uftc8inx 7844 2 were be VBD cord-010092-uftc8inx 7844 3 informed inform VBN cord-010092-uftc8inx 7844 4 of of IN cord-010092-uftc8inx 7844 5 the the DT cord-010092-uftc8inx 7844 6 positive positive JJ cord-010092-uftc8inx 7844 7 results result NNS cord-010092-uftc8inx 7844 8 . . . cord-010092-uftc8inx 7845 1 Results result NNS cord-010092-uftc8inx 7845 2 : : : cord-010092-uftc8inx 7846 1 A a DT cord-010092-uftc8inx 7846 2 total total NN cord-010092-uftc8inx 7846 3 of of IN cord-010092-uftc8inx 7846 4 620 620 CD cord-010092-uftc8inx 7846 5 EDTA EDTA NNP cord-010092-uftc8inx 7846 6 samples sample NNS cord-010092-uftc8inx 7846 7 were be VBD cord-010092-uftc8inx 7846 8 tested test VBN cord-010092-uftc8inx 7846 9 using use VBG cord-010092-uftc8inx 7846 10 the the DT cord-010092-uftc8inx 7846 11 Architect Architect NNP cord-010092-uftc8inx 7846 12 anti anti JJ cord-010092-uftc8inx 7846 13 - - NNP cord-010092-uftc8inx 7846 14 HBcore hbcore JJ cord-010092-uftc8inx 7846 15 , , , cord-010092-uftc8inx 7846 16 anti anti JJ cord-010092-uftc8inx 7846 17 - - NNP cord-010092-uftc8inx 7846 18 HBs HBs NNP cord-010092-uftc8inx 7846 19 , , , cord-010092-uftc8inx 7846 20 nti nti NNP cord-010092-uftc8inx 7846 21 - - HYPH cord-010092-uftc8inx 7846 22 HBcore HBcore NNP cord-010092-uftc8inx 7846 23 - - HYPH cord-010092-uftc8inx 7846 24 M M NNP cord-010092-uftc8inx 7846 25 and and CC cord-010092-uftc8inx 7846 26 anti anti JJ cord-010092-uftc8inx 7846 27 - - JJ cord-010092-uftc8inx 7846 28 HBe hbe JJ cord-010092-uftc8inx 7846 29 assays assay NNS cord-010092-uftc8inx 7846 30 ( ( -LRB- cord-010092-uftc8inx 7846 31 chemiluminescent chemiluminescent NN cord-010092-uftc8inx 7846 32 microparticle microparticle NNP cord-010092-uftc8inx 7846 33 immunoassay immunoassay NNP cord-010092-uftc8inx 7846 34 ( ( -LRB- cord-010092-uftc8inx 7846 35 CMIA CMIA NNP cord-010092-uftc8inx 7846 36 ) ) -RRB- cord-010092-uftc8inx 7846 37 . . . cord-010092-uftc8inx 7847 1 Repeated repeat VBN cord-010092-uftc8inx 7847 2 anti anti JJ cord-010092-uftc8inx 7847 3 - - JJ cord-010092-uftc8inx 7847 4 HBcore(+ hbcore(+ JJ cord-010092-uftc8inx 7847 5 ) ) -RRB- cord-010092-uftc8inx 7847 6 occurred occur VBD cord-010092-uftc8inx 7847 7 in in IN cord-010092-uftc8inx 7847 8 24 24 CD cord-010092-uftc8inx 7847 9 ( ( -LRB- cord-010092-uftc8inx 7847 10 3.87 3.87 CD cord-010092-uftc8inx 7847 11 % % NN cord-010092-uftc8inx 7847 12 ) ) -RRB- cord-010092-uftc8inx 7847 13 samples sample NNS cord-010092-uftc8inx 7847 14 , , , cord-010092-uftc8inx 7847 15 among among IN cord-010092-uftc8inx 7847 16 which which WDT cord-010092-uftc8inx 7847 17 7 7 CD cord-010092-uftc8inx 7847 18 ( ( -LRB- cord-010092-uftc8inx 7847 19 19 19 CD cord-010092-uftc8inx 7847 20 % % NN cord-010092-uftc8inx 7847 21 ) ) -RRB- cord-010092-uftc8inx 7847 22 were be VBD cord-010092-uftc8inx 7847 23 also also RB cord-010092-uftc8inx 7847 24 anti anti JJ cord-010092-uftc8inx 7847 25 - - JJ cord-010092-uftc8inx 7847 26 HBe(+ hbe(+ JJ cord-010092-uftc8inx 7847 27 ) ) -RRB- cord-010092-uftc8inx 7847 28 , , , cord-010092-uftc8inx 7847 29 while while IN cord-010092-uftc8inx 7847 30 anti anti NNP cord-010092-uftc8inx 7847 31 - - NNP cord-010092-uftc8inx 7847 32 HBs HBs NNP cord-010092-uftc8inx 7847 33 was be VBD cord-010092-uftc8inx 7847 34 found find VBN cord-010092-uftc8inx 7847 35 > > XX cord-010092-uftc8inx 7848 1 200 200 CD cord-010092-uftc8inx 7848 2 m m NNP cord-010092-uftc8inx 7848 3 IU IU NNP cord-010092-uftc8inx 7848 4 / / , cord-010092-uftc8inx 7848 5 ml ml NN cord-010092-uftc8inx 7848 6 in in IN cord-010092-uftc8inx 7848 7 15 15 CD cord-010092-uftc8inx 7848 8 ( ( -LRB- cord-010092-uftc8inx 7848 9 62.5 62.5 CD cord-010092-uftc8inx 7848 10 % % NN cord-010092-uftc8inx 7848 11 ) ) -RRB- cord-010092-uftc8inx 7848 12 , , , cord-010092-uftc8inx 7848 13 between between IN cord-010092-uftc8inx 7848 14 100 100 CD cord-010092-uftc8inx 7848 15 and and CC cord-010092-uftc8inx 7848 16 200 200 CD cord-010092-uftc8inx 7848 17 mIU mIU NNS cord-010092-uftc8inx 7848 18 / / SYM cord-010092-uftc8inx 7848 19 ml ml NN cord-010092-uftc8inx 7848 20 in in IN cord-010092-uftc8inx 7848 21 3 3 CD cord-010092-uftc8inx 7848 22 ( ( -LRB- cord-010092-uftc8inx 7848 23 12.5 12.5 CD cord-010092-uftc8inx 7848 24 % % NN cord-010092-uftc8inx 7848 25 ) ) -RRB- cord-010092-uftc8inx 7848 26 , , , cord-010092-uftc8inx 7848 27 and and CC cord-010092-uftc8inx 7848 28 < < XX cord-010092-uftc8inx 7848 29 100 100 CD cord-010092-uftc8inx 7848 30 mIU mIU NNP cord-010092-uftc8inx 7848 31 / / SYM cord-010092-uftc8inx 7848 32 ml ml NN cord-010092-uftc8inx 7848 33 in in IN cord-010092-uftc8inx 7848 34 6 6 CD cord-010092-uftc8inx 7848 35 ( ( -LRB- cord-010092-uftc8inx 7848 36 25 25 CD cord-010092-uftc8inx 7848 37 % % NN cord-010092-uftc8inx 7848 38 ) ) -RRB- cord-010092-uftc8inx 7848 39 . . . cord-010092-uftc8inx 7849 1 Among among IN cord-010092-uftc8inx 7849 2 anti anti JJ cord-010092-uftc8inx 7849 3 - - JJ cord-010092-uftc8inx 7849 4 HBcore hbcore JJ cord-010092-uftc8inx 7849 5 positive positive JJ cord-010092-uftc8inx 7849 6 donors donor NNS cord-010092-uftc8inx 7849 7 , , , cord-010092-uftc8inx 7849 8 4/24 4/24 CD cord-010092-uftc8inx 7849 9 were be VBD cord-010092-uftc8inx 7849 10 foreigners foreigner NNS cord-010092-uftc8inx 7849 11 ( ( -LRB- cord-010092-uftc8inx 7849 12 16.6 16.6 CD cord-010092-uftc8inx 7849 13 % % NN cord-010092-uftc8inx 7849 14 ) ) -RRB- cord-010092-uftc8inx 7849 15 and and CC cord-010092-uftc8inx 7849 16 20 20 CD cord-010092-uftc8inx 7849 17 were be VBD cord-010092-uftc8inx 7849 18 Greeks Greeks NNPS cord-010092-uftc8inx 7849 19 , , , cord-010092-uftc8inx 7849 20 while while IN cord-010092-uftc8inx 7849 21 foreigners foreigner NNS cord-010092-uftc8inx 7849 22 consisted consist VBD cord-010092-uftc8inx 7849 23 6,29 6,29 CD cord-010092-uftc8inx 7849 24 % % NN cord-010092-uftc8inx 7849 25 ( ( -LRB- cord-010092-uftc8inx 7849 26 39/620 39/620 LS cord-010092-uftc8inx 7849 27 ) ) -RRB- cord-010092-uftc8inx 7849 28 of of IN cord-010092-uftc8inx 7849 29 donors donor NNS cord-010092-uftc8inx 7849 30 examined examine VBN cord-010092-uftc8inx 7849 31 . . . cord-010092-uftc8inx 7850 1 So so RB cord-010092-uftc8inx 7850 2 , , , cord-010092-uftc8inx 7850 3 anti anti JJ cord-010092-uftc8inx 7850 4 - - NNP cord-010092-uftc8inx 7850 5 HBcore HBcore NNP cord-010092-uftc8inx 7850 6 was be VBD cord-010092-uftc8inx 7850 7 found find VBN cord-010092-uftc8inx 7850 8 positive positive JJ cord-010092-uftc8inx 7850 9 in in IN cord-010092-uftc8inx 7850 10 10,25 10,25 CD cord-010092-uftc8inx 7850 11 % % NN cord-010092-uftc8inx 7850 12 of of IN cord-010092-uftc8inx 7850 13 foreigners foreigner NNS cord-010092-uftc8inx 7850 14 ( ( -LRB- cord-010092-uftc8inx 7850 15 4/39 4/39 CD cord-010092-uftc8inx 7850 16 , , , cord-010092-uftc8inx 7850 17 all all DT cord-010092-uftc8inx 7850 18 from from IN cord-010092-uftc8inx 7850 19 countries country NNS cord-010092-uftc8inx 7850 20 with with IN cord-010092-uftc8inx 7850 21 high high JJ cord-010092-uftc8inx 7850 22 prevalence prevalence NN cord-010092-uftc8inx 7850 23 for for IN cord-010092-uftc8inx 7850 24 hepatitis hepatitis NN cord-010092-uftc8inx 7850 25 B B NNP cord-010092-uftc8inx 7850 26 infection infection NN cord-010092-uftc8inx 7850 27 ) ) -RRB- cord-010092-uftc8inx 7850 28 and and CC cord-010092-uftc8inx 7850 29 in in IN cord-010092-uftc8inx 7850 30 3,44 3,44 CD cord-010092-uftc8inx 7850 31 % % NN cord-010092-uftc8inx 7850 32 of of IN cord-010092-uftc8inx 7850 33 Greeks Greeks NNPS cord-010092-uftc8inx 7850 34 ( ( -LRB- cord-010092-uftc8inx 7850 35 20/581 20/581 CD cord-010092-uftc8inx 7850 36 ) ) -RRB- cord-010092-uftc8inx 7850 37 . . . cord-010092-uftc8inx 7851 1 In in IN cord-010092-uftc8inx 7851 2 total total JJ cord-010092-uftc8inx 7851 3 , , , cord-010092-uftc8inx 7851 4 285 285 CD cord-010092-uftc8inx 7851 5 ( ( -LRB- cord-010092-uftc8inx 7851 6 45.96 45.96 CD cord-010092-uftc8inx 7851 7 % % NN cord-010092-uftc8inx 7851 8 ) ) -RRB- cord-010092-uftc8inx 7851 9 samples sample NNS cord-010092-uftc8inx 7851 10 had have VBD cord-010092-uftc8inx 7851 11 anti anti JJ cord-010092-uftc8inx 7851 12 - - JJ cord-010092-uftc8inx 7851 13 HBs hb NNS cord-010092-uftc8inx 7851 14 > > XX cord-010092-uftc8inx 7852 1 10 10 CD cord-010092-uftc8inx 7852 2 mIU mIU NNP cord-010092-uftc8inx 7852 3 / / SYM cord-010092-uftc8inx 7852 4 ml ml NN cord-010092-uftc8inx 7852 5 ( ( -LRB- cord-010092-uftc8inx 7852 6 considered consider VBN cord-010092-uftc8inx 7852 7 seroprotective seroprotective NNP cord-010092-uftc8inx 7852 8 for for IN cord-010092-uftc8inx 7852 9 the the DT cord-010092-uftc8inx 7852 10 donor donor NN cord-010092-uftc8inx 7852 11 ) ) -RRB- cord-010092-uftc8inx 7852 12 . . . cord-010092-uftc8inx 7853 1 Summary Summary NNP cord-010092-uftc8inx 7853 2 / / SYM cord-010092-uftc8inx 7853 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 7853 4 : : : cord-010092-uftc8inx 7854 1 Almost almost RB cord-010092-uftc8inx 7854 2 half half NN cord-010092-uftc8inx 7854 3 of of IN cord-010092-uftc8inx 7854 4 our -PRON- PRP$ cord-010092-uftc8inx 7854 5 blood blood NN cord-010092-uftc8inx 7854 6 donors donor NNS cord-010092-uftc8inx 7854 7 ( ( -LRB- cord-010092-uftc8inx 7854 8 45.96 45.96 CD cord-010092-uftc8inx 7854 9 % % NN cord-010092-uftc8inx 7854 10 ) ) -RRB- cord-010092-uftc8inx 7854 11 were be VBD cord-010092-uftc8inx 7854 12 immunized immunize VBN cord-010092-uftc8inx 7854 13 , , , cord-010092-uftc8inx 7854 14 261 261 CD cord-010092-uftc8inx 7854 15 by by IN cord-010092-uftc8inx 7854 16 vaccination vaccination NN cord-010092-uftc8inx 7854 17 and and CC cord-010092-uftc8inx 7854 18 24 24 CD cord-010092-uftc8inx 7854 19 ( ( -LRB- cord-010092-uftc8inx 7854 20 3.87 3.87 CD cord-010092-uftc8inx 7854 21 % % NN cord-010092-uftc8inx 7854 22 ) ) -RRB- cord-010092-uftc8inx 7854 23 by by IN cord-010092-uftc8inx 7854 24 natural natural JJ cord-010092-uftc8inx 7854 25 infection infection NN cord-010092-uftc8inx 7854 26 . . . cord-010092-uftc8inx 7855 1 The the DT cord-010092-uftc8inx 7855 2 incidence incidence NN cord-010092-uftc8inx 7855 3 of of IN cord-010092-uftc8inx 7855 4 natural natural JJ cord-010092-uftc8inx 7855 5 infection infection NN cord-010092-uftc8inx 7855 6 was be VBD cord-010092-uftc8inx 7855 7 significantly significantly RB cord-010092-uftc8inx 7855 8 higher high JJR cord-010092-uftc8inx 7855 9 in in IN cord-010092-uftc8inx 7855 10 foreigners foreigner NNS cord-010092-uftc8inx 7855 11 ( ( -LRB- cord-010092-uftc8inx 7855 12 10.25 10.25 CD cord-010092-uftc8inx 7855 13 % % NN cord-010092-uftc8inx 7855 14 versus versus IN cord-010092-uftc8inx 7855 15 3,44 3,44 CD cord-010092-uftc8inx 7855 16 % % NN cord-010092-uftc8inx 7855 17 ) ) -RRB- cord-010092-uftc8inx 7855 18 . . . cord-010092-uftc8inx 7856 1 If if IN cord-010092-uftc8inx 7856 2 not not RB cord-010092-uftc8inx 7856 3 all all DT cord-010092-uftc8inx 7856 4 anti anti JJ cord-010092-uftc8inx 7856 5 - - JJ cord-010092-uftc8inx 7856 6 HBcore+ hbcore+ JJ cord-010092-uftc8inx 7856 7 donors donor NNS cord-010092-uftc8inx 7856 8 , , , cord-010092-uftc8inx 7856 9 25 25 CD cord-010092-uftc8inx 7856 10 % % NN cord-010092-uftc8inx 7856 11 with with IN cord-010092-uftc8inx 7856 12 anti anti JJ cord-010092-uftc8inx 7856 13 - - JJ cord-010092-uftc8inx 7856 14 HBs hbs JJ cord-010092-uftc8inx 7856 15 < < XX cord-010092-uftc8inx 7856 16 100 100 CD cord-010092-uftc8inx 7856 17 IU IU NNP cord-010092-uftc8inx 7856 18 / / SYM cord-010092-uftc8inx 7856 19 ml ml NN cord-010092-uftc8inx 7856 20 , , , cord-010092-uftc8inx 7856 21 might may MD cord-010092-uftc8inx 7856 22 be be VB cord-010092-uftc8inx 7856 23 potentially potentially RB cord-010092-uftc8inx 7856 24 infectious infectious JJ cord-010092-uftc8inx 7856 25 , , , cord-010092-uftc8inx 7856 26 especially especially RB cord-010092-uftc8inx 7856 27 for for IN cord-010092-uftc8inx 7856 28 immunocompromised immunocompromised JJ cord-010092-uftc8inx 7856 29 patients patient NNS cord-010092-uftc8inx 7856 30 . . . cord-010092-uftc8inx 7857 1 If if IN cord-010092-uftc8inx 7857 2 we -PRON- PRP cord-010092-uftc8inx 7857 3 choose choose VBP cord-010092-uftc8inx 7857 4 to to TO cord-010092-uftc8inx 7857 5 screen screen VB cord-010092-uftc8inx 7857 6 all all DT cord-010092-uftc8inx 7857 7 blood blood NN cord-010092-uftc8inx 7857 8 donors donor NNS cord-010092-uftc8inx 7857 9 for for IN cord-010092-uftc8inx 7857 10 anti anti JJ cord-010092-uftc8inx 7857 11 - - JJ cord-010092-uftc8inx 7857 12 HBcore hbcore JJ cord-010092-uftc8inx 7857 13 and and CC cord-010092-uftc8inx 7857 14 reject reject VBP cord-010092-uftc8inx 7857 15 those those DT cord-010092-uftc8inx 7857 16 with with IN cord-010092-uftc8inx 7857 17 positive positive JJ cord-010092-uftc8inx 7857 18 results result NNS cord-010092-uftc8inx 7857 19 , , , cord-010092-uftc8inx 7857 20 regardless regardless RB cord-010092-uftc8inx 7857 21 of of IN cord-010092-uftc8inx 7857 22 the the DT cord-010092-uftc8inx 7857 23 anti anti JJ cord-010092-uftc8inx 7857 24 - - JJ cord-010092-uftc8inx 7857 25 HBs hbs JJ cord-010092-uftc8inx 7857 26 levels level NNS cord-010092-uftc8inx 7857 27 , , , cord-010092-uftc8inx 7857 28 we -PRON- PRP cord-010092-uftc8inx 7857 29 would would MD cord-010092-uftc8inx 7857 30 probably probably RB cord-010092-uftc8inx 7857 31 lose lose VB cord-010092-uftc8inx 7857 32 a a DT cord-010092-uftc8inx 7857 33 significant significant JJ cord-010092-uftc8inx 7857 34 number number NN cord-010092-uftc8inx 7857 35 of of IN cord-010092-uftc8inx 7857 36 donors donor NNS cord-010092-uftc8inx 7857 37 and and CC cord-010092-uftc8inx 7857 38 jeopardize jeopardize VB cord-010092-uftc8inx 7857 39 blood blood NN cord-010092-uftc8inx 7857 40 sufficiency sufficiency NN cord-010092-uftc8inx 7857 41 . . . cord-010092-uftc8inx 7858 1 Alternatively alternatively RB cord-010092-uftc8inx 7858 2 , , , cord-010092-uftc8inx 7858 3 we -PRON- PRP cord-010092-uftc8inx 7858 4 could could MD cord-010092-uftc8inx 7858 5 reject reject VB cord-010092-uftc8inx 7858 6 only only RB cord-010092-uftc8inx 7858 7 those those DT cord-010092-uftc8inx 7858 8 with with IN cord-010092-uftc8inx 7858 9 anti anti JJ cord-010092-uftc8inx 7858 10 - - JJ cord-010092-uftc8inx 7858 11 HBs HBs NNP cord-010092-uftc8inx 7858 12 < < XX cord-010092-uftc8inx 7858 13 100 100 CD cord-010092-uftc8inx 7858 14 or or CC cord-010092-uftc8inx 7858 15 < < XX cord-010092-uftc8inx 7858 16 200 200 CD cord-010092-uftc8inx 7858 17 , , , cord-010092-uftc8inx 7858 18 or or CC cord-010092-uftc8inx 7858 19 choose choose VB cord-010092-uftc8inx 7858 20 to to TO cord-010092-uftc8inx 7858 21 selectively selectively RB cord-010092-uftc8inx 7858 22 screen screen VB cord-010092-uftc8inx 7858 23 pre pre JJ cord-010092-uftc8inx 7858 24 - - JJ cord-010092-uftc8inx 7858 25 donation donation JJ cord-010092-uftc8inx 7858 26 blood blood NN cord-010092-uftc8inx 7858 27 donors donor NNS cord-010092-uftc8inx 7858 28 from from IN cord-010092-uftc8inx 7858 29 countries country NNS cord-010092-uftc8inx 7858 30 with with IN cord-010092-uftc8inx 7858 31 high high JJ cord-010092-uftc8inx 7858 32 prevalence prevalence NN cord-010092-uftc8inx 7858 33 of of IN cord-010092-uftc8inx 7858 34 HBV HBV NNP cord-010092-uftc8inx 7858 35 infection infection NN cord-010092-uftc8inx 7858 36 . . . cord-010092-uftc8inx 7859 1 Following follow VBG cord-010092-uftc8inx 7859 2 this this DT cord-010092-uftc8inx 7859 3 pilot pilot NN cord-010092-uftc8inx 7859 4 study study NN cord-010092-uftc8inx 7859 5 , , , cord-010092-uftc8inx 7859 6 the the DT cord-010092-uftc8inx 7859 7 prevalence prevalence NN cord-010092-uftc8inx 7859 8 of of IN cord-010092-uftc8inx 7859 9 immunization immunization NN cord-010092-uftc8inx 7859 10 against against IN cord-010092-uftc8inx 7859 11 HBV HBV NNP cord-010092-uftc8inx 7859 12 in in IN cord-010092-uftc8inx 7859 13 large large JJ cord-010092-uftc8inx 7859 14 numbers number NNS cord-010092-uftc8inx 7859 15 of of IN cord-010092-uftc8inx 7859 16 blood blood NN cord-010092-uftc8inx 7859 17 donors donor NNS cord-010092-uftc8inx 7859 18 from from IN cord-010092-uftc8inx 7859 19 various various JJ cord-010092-uftc8inx 7859 20 parts part NNS cord-010092-uftc8inx 7859 21 of of IN cord-010092-uftc8inx 7859 22 Greece Greece NNP cord-010092-uftc8inx 7859 23 , , , cord-010092-uftc8inx 7859 24 must must MD cord-010092-uftc8inx 7859 25 be be VB cord-010092-uftc8inx 7859 26 investigated investigate VBN cord-010092-uftc8inx 7859 27 , , , cord-010092-uftc8inx 7859 28 in in IN cord-010092-uftc8inx 7859 29 order order NN cord-010092-uftc8inx 7859 30 to to TO cord-010092-uftc8inx 7859 31 decide decide VB cord-010092-uftc8inx 7859 32 whether whether IN cord-010092-uftc8inx 7859 33 to to TO cord-010092-uftc8inx 7859 34 introduce introduce VB cord-010092-uftc8inx 7859 35 such such JJ cord-010092-uftc8inx 7859 36 screening screening NN cord-010092-uftc8inx 7859 37 . . . cord-010092-uftc8inx 7860 1 Aims aim VBZ cord-010092-uftc8inx 7860 2 : : : cord-010092-uftc8inx 7861 1 The the DT cord-010092-uftc8inx 7861 2 aim aim NN cord-010092-uftc8inx 7861 3 of of IN cord-010092-uftc8inx 7861 4 this this DT cord-010092-uftc8inx 7861 5 study study NN cord-010092-uftc8inx 7861 6 was be VBD cord-010092-uftc8inx 7861 7 to to TO cord-010092-uftc8inx 7861 8 perform perform VB cord-010092-uftc8inx 7861 9 phylogenetic phylogenetic JJ cord-010092-uftc8inx 7861 10 analysis analysis NN cord-010092-uftc8inx 7861 11 of of IN cord-010092-uftc8inx 7861 12 the the DT cord-010092-uftc8inx 7861 13 donor donor NN cord-010092-uftc8inx 7861 14 samples sample NNS cord-010092-uftc8inx 7861 15 with with IN cord-010092-uftc8inx 7861 16 HCV HCV NNP cord-010092-uftc8inx 7861 17 found find VBD cord-010092-uftc8inx 7861 18 in in IN cord-010092-uftc8inx 7861 19 the the DT cord-010092-uftc8inx 7861 20 neighbouring neighbour VBG cord-010092-uftc8inx 7861 21 villages village NNS cord-010092-uftc8inx 7861 22 to to TO cord-010092-uftc8inx 7861 23 determine determine VB cord-010092-uftc8inx 7861 24 the the DT cord-010092-uftc8inx 7861 25 nature nature NN cord-010092-uftc8inx 7861 26 of of IN cord-010092-uftc8inx 7861 27 transmission transmission NN cord-010092-uftc8inx 7861 28 . . . cord-010092-uftc8inx 7862 1 Methods method NNS cord-010092-uftc8inx 7862 2 : : : cord-010092-uftc8inx 7862 3 Altogether altogether RB cord-010092-uftc8inx 7862 4 , , , cord-010092-uftc8inx 7862 5 approximately approximately RB cord-010092-uftc8inx 7862 6 2 2 CD cord-010092-uftc8inx 7862 7 million million CD cord-010092-uftc8inx 7862 8 blood blood NN cord-010092-uftc8inx 7862 9 donor donor NN cord-010092-uftc8inx 7862 10 samples sample NNS cord-010092-uftc8inx 7862 11 were be VBD cord-010092-uftc8inx 7862 12 screened screen VBN cord-010092-uftc8inx 7862 13 with with IN cord-010092-uftc8inx 7862 14 anti anti JJ cord-010092-uftc8inx 7862 15 - - JJ cord-010092-uftc8inx 7862 16 HCV hcv JJ cord-010092-uftc8inx 7862 17 immunoassay immunoassay NN cord-010092-uftc8inx 7862 18 ( ( -LRB- cord-010092-uftc8inx 7862 19 Architect Architect NNP cord-010092-uftc8inx 7862 20 anti anti JJ cord-010092-uftc8inx 7862 21 - - NNP cord-010092-uftc8inx 7862 22 HCV HCV NNP cord-010092-uftc8inx 7862 23 , , , cord-010092-uftc8inx 7862 24 Abbott Abbott NNP cord-010092-uftc8inx 7862 25 GmbH GmbH NNP cord-010092-uftc8inx 7862 26 , , , cord-010092-uftc8inx 7862 27 Wiesbaden Wiesbaden NNP cord-010092-uftc8inx 7862 28 , , , cord-010092-uftc8inx 7862 29 Germany Germany NNP cord-010092-uftc8inx 7862 30 ) ) -RRB- cord-010092-uftc8inx 7862 31 and and CC cord-010092-uftc8inx 7863 1 reactive reactive JJ cord-010092-uftc8inx 7863 2 results result NNS cord-010092-uftc8inx 7863 3 were be VBD cord-010092-uftc8inx 7863 4 confirmed confirm VBN cord-010092-uftc8inx 7863 5 with with IN cord-010092-uftc8inx 7863 6 anti anti JJ cord-010092-uftc8inx 7863 7 - - JJ cord-010092-uftc8inx 7863 8 HCV hcv JJ cord-010092-uftc8inx 7863 9 line line NN cord-010092-uftc8inx 7863 10 - - HYPH cord-010092-uftc8inx 7863 11 immunoassays immunoassays NNP cord-010092-uftc8inx 7863 12 ( ( -LRB- cord-010092-uftc8inx 7863 13 INNO INNO NNP cord-010092-uftc8inx 7863 14 - - HYPH cord-010092-uftc8inx 7863 15 LIA LIA NNP cord-010092-uftc8inx 7863 16 HCV HCV NNP cord-010092-uftc8inx 7863 17 Score Score NNP cord-010092-uftc8inx 7863 18 , , , cord-010092-uftc8inx 7863 19 Fujirebio Fujirebio NNP cord-010092-uftc8inx 7863 20 Europe Europe NNP cord-010092-uftc8inx 7863 21 , , , cord-010092-uftc8inx 7863 22 Gent Gent NNP cord-010092-uftc8inx 7863 23 , , , cord-010092-uftc8inx 7863 24 Belgium Belgium NNP cord-010092-uftc8inx 7863 25 ) ) -RRB- cord-010092-uftc8inx 7863 26 . . . cord-010092-uftc8inx 7864 1 Based base VBN cord-010092-uftc8inx 7864 2 on on IN cord-010092-uftc8inx 7864 3 LIA LIA NNP cord-010092-uftc8inx 7864 4 positivity positivity NN cord-010092-uftc8inx 7864 5 , , , cord-010092-uftc8inx 7864 6 in in IN cord-010092-uftc8inx 7864 7 20 20 CD cord-010092-uftc8inx 7864 8 samples sample NNS cord-010092-uftc8inx 7864 9 an an DT cord-010092-uftc8inx 7864 10 association association NN cord-010092-uftc8inx 7864 11 of of IN cord-010092-uftc8inx 7864 12 HCV HCV NNP cord-010092-uftc8inx 7864 13 infection infection NN cord-010092-uftc8inx 7864 14 was be VBD cord-010092-uftc8inx 7864 15 supposed suppose VBN cord-010092-uftc8inx 7864 16 , , , cord-010092-uftc8inx 7864 17 because because IN cord-010092-uftc8inx 7864 18 the the DT cord-010092-uftc8inx 7864 19 residence residence NN cord-010092-uftc8inx 7864 20 places place NNS cord-010092-uftc8inx 7864 21 of of IN cord-010092-uftc8inx 7864 22 donors donor NNS cord-010092-uftc8inx 7864 23 were be VBD cord-010092-uftc8inx 7864 24 in in IN cord-010092-uftc8inx 7864 25 three three CD cord-010092-uftc8inx 7864 26 neighbouring neighbouring JJ cord-010092-uftc8inx 7864 27 villages village NNS cord-010092-uftc8inx 7864 28 situated situate VBD cord-010092-uftc8inx 7864 29 less less JJR cord-010092-uftc8inx 7864 30 than than IN cord-010092-uftc8inx 7864 31 20 20 CD cord-010092-uftc8inx 7864 32 km km NN cord-010092-uftc8inx 7864 33 to to IN cord-010092-uftc8inx 7864 34 each each DT cord-010092-uftc8inx 7864 35 other other JJ cord-010092-uftc8inx 7864 36 . . . cord-010092-uftc8inx 7865 1 PCR PCR NNP cord-010092-uftc8inx 7865 2 was be VBD cord-010092-uftc8inx 7865 3 positive positive JJ cord-010092-uftc8inx 7865 4 in in IN cord-010092-uftc8inx 7865 5 15 15 CD cord-010092-uftc8inx 7865 6 samples sample NNS cord-010092-uftc8inx 7865 7 . . . cord-010092-uftc8inx 7866 1 From from IN cord-010092-uftc8inx 7866 2 these these DT cord-010092-uftc8inx 7866 3 samples sample NNS cord-010092-uftc8inx 7866 4 , , , cord-010092-uftc8inx 7866 5 HCV HCV NNP cord-010092-uftc8inx 7866 6 sequencing sequencing NN cord-010092-uftc8inx 7866 7 and and CC cord-010092-uftc8inx 7866 8 phylogenetic phylogenetic NN cord-010092-uftc8inx 7866 9 analysis analysis NN cord-010092-uftc8inx 7866 10 were be VBD cord-010092-uftc8inx 7866 11 performed perform VBN cord-010092-uftc8inx 7866 12 . . . cord-010092-uftc8inx 7867 1 Fourteen fourteen CD cord-010092-uftc8inx 7867 2 HCV HCV NNP cord-010092-uftc8inx 7867 3 infected infect VBN cord-010092-uftc8inx 7867 4 samples sample NNS cord-010092-uftc8inx 7867 5 of of IN cord-010092-uftc8inx 7867 6 general general JJ cord-010092-uftc8inx 7867 7 population population NN cord-010092-uftc8inx 7867 8 and and CC cord-010092-uftc8inx 7867 9 11 11 CD cord-010092-uftc8inx 7867 10 of of IN cord-010092-uftc8inx 7867 11 IVD IVD NNP cord-010092-uftc8inx 7867 12 users user NNS cord-010092-uftc8inx 7867 13 were be VBD cord-010092-uftc8inx 7867 14 also also RB cord-010092-uftc8inx 7867 15 included include VBN cord-010092-uftc8inx 7867 16 into into IN cord-010092-uftc8inx 7867 17 the the DT cord-010092-uftc8inx 7867 18 study study NN cord-010092-uftc8inx 7867 19 . . . cord-010092-uftc8inx 7868 1 Results result NNS cord-010092-uftc8inx 7868 2 : : : cord-010092-uftc8inx 7869 1 Phylogenetic phylogenetic JJ cord-010092-uftc8inx 7869 2 analysis analysis NN cord-010092-uftc8inx 7869 3 detected detect VBD cord-010092-uftc8inx 7869 4 genetic genetic JJ cord-010092-uftc8inx 7869 5 relationship relationship NN cord-010092-uftc8inx 7869 6 among among IN cord-010092-uftc8inx 7869 7 the the DT cord-010092-uftc8inx 7869 8 HCV HCV NNP cord-010092-uftc8inx 7869 9 virus virus NN cord-010092-uftc8inx 7869 10 sequences sequence NNS cord-010092-uftc8inx 7869 11 in in IN cord-010092-uftc8inx 7869 12 donor donor NN cord-010092-uftc8inx 7869 13 samples sample NNS cord-010092-uftc8inx 7869 14 . . . cord-010092-uftc8inx 7870 1 The the DT cord-010092-uftc8inx 7870 2 most most RBS cord-010092-uftc8inx 7870 3 abundant abundant JJ cord-010092-uftc8inx 7870 4 was be VBD cord-010092-uftc8inx 7870 5 the the DT cord-010092-uftc8inx 7870 6 1a 1a CD cord-010092-uftc8inx 7870 7 subtype subtype NN cord-010092-uftc8inx 7870 8 , , , cord-010092-uftc8inx 7870 9 and and CC cord-010092-uftc8inx 7870 10 it -PRON- PRP cord-010092-uftc8inx 7870 11 formed form VBD cord-010092-uftc8inx 7870 12 two two CD cord-010092-uftc8inx 7870 13 different different JJ cord-010092-uftc8inx 7870 14 groups group NNS cord-010092-uftc8inx 7870 15 on on IN cord-010092-uftc8inx 7870 16 the the DT cord-010092-uftc8inx 7870 17 phylogenetic phylogenetic JJ cord-010092-uftc8inx 7870 18 tree tree NN cord-010092-uftc8inx 7870 19 . . . cord-010092-uftc8inx 7871 1 According accord VBG cord-010092-uftc8inx 7871 2 to to IN cord-010092-uftc8inx 7871 3 their -PRON- PRP$ cord-010092-uftc8inx 7871 4 genetic genetic JJ cord-010092-uftc8inx 7871 5 distance distance NN cord-010092-uftc8inx 7871 6 , , , cord-010092-uftc8inx 7871 7 a a DT cord-010092-uftc8inx 7871 8 more more RBR cord-010092-uftc8inx 7871 9 distant distant JJ cord-010092-uftc8inx 7871 10 mutual mutual JJ cord-010092-uftc8inx 7871 11 ancestor ancestor NN cord-010092-uftc8inx 7871 12 could could MD cord-010092-uftc8inx 7871 13 be be VB cord-010092-uftc8inx 7871 14 supposed suppose VBN cord-010092-uftc8inx 7871 15 . . . cord-010092-uftc8inx 7872 1 Two two CD cord-010092-uftc8inx 7872 2 samples sample NNS cord-010092-uftc8inx 7872 3 with with IN cord-010092-uftc8inx 7872 4 1b 1b CD cord-010092-uftc8inx 7872 5 subtype subtype NN cord-010092-uftc8inx 7872 6 originated originate VBD cord-010092-uftc8inx 7872 7 from from IN cord-010092-uftc8inx 7872 8 the the DT cord-010092-uftc8inx 7872 9 same same JJ cord-010092-uftc8inx 7872 10 village village NN cord-010092-uftc8inx 7872 11 , , , cord-010092-uftc8inx 7872 12 and and CC cord-010092-uftc8inx 7872 13 their -PRON- PRP$ cord-010092-uftc8inx 7872 14 difference difference NN cord-010092-uftc8inx 7872 15 was be VBD cord-010092-uftc8inx 7872 16 only only RB cord-010092-uftc8inx 7872 17 2 2 CD cord-010092-uftc8inx 7872 18 nucleotides nucleotide NNS cord-010092-uftc8inx 7872 19 . . . cord-010092-uftc8inx 7873 1 Three three CD cord-010092-uftc8inx 7873 2 HCV HCV NNP cord-010092-uftc8inx 7873 3 from from IN cord-010092-uftc8inx 7873 4 the the DT cord-010092-uftc8inx 7873 5 IVD IVD NNP cord-010092-uftc8inx 7873 6 user user NN cord-010092-uftc8inx 7873 7 control control NN cord-010092-uftc8inx 7873 8 group group NN cord-010092-uftc8inx 7873 9 showed show VBD cord-010092-uftc8inx 7873 10 close close JJ cord-010092-uftc8inx 7873 11 genetic genetic JJ cord-010092-uftc8inx 7873 12 relationship relationship NN cord-010092-uftc8inx 7873 13 with with IN cord-010092-uftc8inx 7873 14 the the DT cord-010092-uftc8inx 7873 15 viruses virus NNS cord-010092-uftc8inx 7873 16 detected detect VBN cord-010092-uftc8inx 7873 17 in in IN cord-010092-uftc8inx 7873 18 the the DT cord-010092-uftc8inx 7873 19 donor donor NN cord-010092-uftc8inx 7873 20 samples sample NNS cord-010092-uftc8inx 7873 21 . . . cord-010092-uftc8inx 7874 1 Summary Summary NNP cord-010092-uftc8inx 7874 2 / / SYM cord-010092-uftc8inx 7874 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 7874 4 : : : cord-010092-uftc8inx 7875 1 Based base VBN cord-010092-uftc8inx 7875 2 on on IN cord-010092-uftc8inx 7875 3 our -PRON- PRP$ cord-010092-uftc8inx 7875 4 phylogenetic phylogenetic JJ cord-010092-uftc8inx 7875 5 analysis analysis NN cord-010092-uftc8inx 7875 6 , , , cord-010092-uftc8inx 7875 7 HCV HCV NNP cord-010092-uftc8inx 7875 8 transmission transmission NN cord-010092-uftc8inx 7875 9 in in IN cord-010092-uftc8inx 7875 10 blood blood NN cord-010092-uftc8inx 7875 11 donors donor NNS cord-010092-uftc8inx 7875 12 could could MD cord-010092-uftc8inx 7875 13 be be VB cord-010092-uftc8inx 7875 14 the the DT cord-010092-uftc8inx 7875 15 consequence consequence NN cord-010092-uftc8inx 7875 16 of of IN cord-010092-uftc8inx 7875 17 the the DT cord-010092-uftc8inx 7875 18 IVD IVD NNP cord-010092-uftc8inx 7875 19 use use NN cord-010092-uftc8inx 7875 20 and and CC cord-010092-uftc8inx 7875 21 the the DT cord-010092-uftc8inx 7875 22 origin origin NN cord-010092-uftc8inx 7875 23 might may MD cord-010092-uftc8inx 7875 24 be be VB cord-010092-uftc8inx 7875 25 related relate VBN cord-010092-uftc8inx 7875 26 to to IN cord-010092-uftc8inx 7875 27 2 2 CD cord-010092-uftc8inx 7875 28 or or CC cord-010092-uftc8inx 7875 29 3 3 CD cord-010092-uftc8inx 7875 30 primary primary JJ cord-010092-uftc8inx 7875 31 human human JJ cord-010092-uftc8inx 7875 32 sources source NNS cord-010092-uftc8inx 7875 33 . . . cord-010092-uftc8inx 7876 1 During during IN cord-010092-uftc8inx 7876 2 2011 2011 CD cord-010092-uftc8inx 7876 3 and and CC cord-010092-uftc8inx 7876 4 2014 2014 CD cord-010092-uftc8inx 7876 5 , , , cord-010092-uftc8inx 7876 6 a a DT cord-010092-uftc8inx 7876 7 significant significant JJ cord-010092-uftc8inx 7876 8 increase increase NN cord-010092-uftc8inx 7876 9 in in IN cord-010092-uftc8inx 7876 10 the the DT cord-010092-uftc8inx 7876 11 HCV HCV NNP cord-010092-uftc8inx 7876 12 seroprevalence seroprevalence NN cord-010092-uftc8inx 7876 13 among among IN cord-010092-uftc8inx 7876 14 the the DT cord-010092-uftc8inx 7876 15 IVD IVD NNP cord-010092-uftc8inx 7876 16 users user NNS cord-010092-uftc8inx 7876 17 was be VBD cord-010092-uftc8inx 7876 18 observed observe VBN cord-010092-uftc8inx 7876 19 , , , cord-010092-uftc8inx 7876 20 which which WDT cord-010092-uftc8inx 7876 21 was be VBD cord-010092-uftc8inx 7876 22 approximately approximately RB cord-010092-uftc8inx 7876 23 threefold threefold JJ cord-010092-uftc8inx 7876 24 in in IN cord-010092-uftc8inx 7876 25 the the DT cord-010092-uftc8inx 7876 26 rural rural JJ cord-010092-uftc8inx 7876 27 areas area NNS cord-010092-uftc8inx 7876 28 of of IN cord-010092-uftc8inx 7876 29 Hungary Hungary NNP cord-010092-uftc8inx 7876 30 . . . cord-010092-uftc8inx 7877 1 Our -PRON- PRP$ cord-010092-uftc8inx 7877 2 recent recent JJ cord-010092-uftc8inx 7877 3 findings finding NNS cord-010092-uftc8inx 7877 4 highlight highlight VBP cord-010092-uftc8inx 7877 5 the the DT cord-010092-uftc8inx 7877 6 importance importance NN cord-010092-uftc8inx 7877 7 of of IN cord-010092-uftc8inx 7877 8 the the DT cord-010092-uftc8inx 7877 9 proper proper JJ cord-010092-uftc8inx 7877 10 donor donor NN cord-010092-uftc8inx 7877 11 selection selection NN cord-010092-uftc8inx 7877 12 , , , cord-010092-uftc8inx 7877 13 which which WDT cord-010092-uftc8inx 7877 14 can can MD cord-010092-uftc8inx 7877 15 identify identify VB cord-010092-uftc8inx 7877 16 the the DT cord-010092-uftc8inx 7877 17 typical typical JJ cord-010092-uftc8inx 7877 18 signs sign NNS cord-010092-uftc8inx 7877 19 of of IN cord-010092-uftc8inx 7877 20 the the DT cord-010092-uftc8inx 7877 21 IVD IVD NNP cord-010092-uftc8inx 7877 22 use use NN cord-010092-uftc8inx 7877 23 . . . cord-010092-uftc8inx 7878 1 Moreover moreover RB cord-010092-uftc8inx 7878 2 , , , cord-010092-uftc8inx 7878 3 enhancing enhance VBG cord-010092-uftc8inx 7878 4 awareness awareness NN cord-010092-uftc8inx 7878 5 of of IN cord-010092-uftc8inx 7878 6 blood blood NN cord-010092-uftc8inx 7878 7 donors donor NNS cord-010092-uftc8inx 7878 8 with with IN cord-010092-uftc8inx 7878 9 education education NN cord-010092-uftc8inx 7878 10 is be VBZ cord-010092-uftc8inx 7878 11 a a DT cord-010092-uftc8inx 7878 12 further further JJ cord-010092-uftc8inx 7878 13 significant significant JJ cord-010092-uftc8inx 7878 14 issue issue NN cord-010092-uftc8inx 7878 15 in in IN cord-010092-uftc8inx 7878 16 order order NN cord-010092-uftc8inx 7878 17 to to TO cord-010092-uftc8inx 7878 18 reduce reduce VB cord-010092-uftc8inx 7878 19 the the DT cord-010092-uftc8inx 7878 20 risk risk NN cord-010092-uftc8inx 7878 21 of of IN cord-010092-uftc8inx 7878 22 transfusion transfusion NN cord-010092-uftc8inx 7878 23 transmitted transmit VBN cord-010092-uftc8inx 7878 24 infections infection NNS cord-010092-uftc8inx 7878 25 . . . cord-010092-uftc8inx 7879 1 Abstract Abstract NNP cord-010092-uftc8inx 7879 2 withdrawn withdraw VBN cord-010092-uftc8inx 7879 3 . . . cord-010092-uftc8inx 7880 1 Background background NN cord-010092-uftc8inx 7880 2 : : : cord-010092-uftc8inx 7881 1 In in IN cord-010092-uftc8inx 7881 2 China China NNP cord-010092-uftc8inx 7881 3 , , , cord-010092-uftc8inx 7881 4 the the DT cord-010092-uftc8inx 7881 5 residual residual JJ cord-010092-uftc8inx 7881 6 risk risk NN cord-010092-uftc8inx 7881 7 of of IN cord-010092-uftc8inx 7881 8 transfusion transfusion NN cord-010092-uftc8inx 7881 9 - - HYPH cord-010092-uftc8inx 7881 10 transmitted transmit VBN cord-010092-uftc8inx 7881 11 HCV HCV NNP cord-010092-uftc8inx 7881 12 has have VBZ cord-010092-uftc8inx 7881 13 been be VBN cord-010092-uftc8inx 7881 14 declining decline VBG cord-010092-uftc8inx 7881 15 since since IN cord-010092-uftc8inx 7881 16 screening screening NN cord-010092-uftc8inx 7881 17 of of IN cord-010092-uftc8inx 7881 18 blood blood NN cord-010092-uftc8inx 7881 19 donors donor NNS cord-010092-uftc8inx 7881 20 for for IN cord-010092-uftc8inx 7881 21 anti anti JJ cord-010092-uftc8inx 7881 22 - - JJ cord-010092-uftc8inx 7881 23 HCV HCV NNP cord-010092-uftc8inx 7881 24 and/or and/or CC cord-010092-uftc8inx 7881 25 HCV HCV NNP cord-010092-uftc8inx 7881 26 NAT NAT NNP cord-010092-uftc8inx 7881 27 from from IN cord-010092-uftc8inx 7881 28 1993 1993 CD cord-010092-uftc8inx 7881 29 . . . cord-010092-uftc8inx 7882 1 However however RB cord-010092-uftc8inx 7882 2 , , , cord-010092-uftc8inx 7882 3 many many JJ cord-010092-uftc8inx 7882 4 high high JJ cord-010092-uftc8inx 7882 5 sensitivity sensitivity NN cord-010092-uftc8inx 7882 6 reagent reagent NN cord-010092-uftc8inx 7882 7 , , , cord-010092-uftc8inx 7882 8 using use VBG cord-010092-uftc8inx 7882 9 to to TO cord-010092-uftc8inx 7882 10 test test VB cord-010092-uftc8inx 7882 11 blood blood NN cord-010092-uftc8inx 7882 12 donors donor NNS cord-010092-uftc8inx 7882 13 ' ' POS cord-010092-uftc8inx 7882 14 samples sample NNS cord-010092-uftc8inx 7882 15 , , , cord-010092-uftc8inx 7882 16 lead lead VBP cord-010092-uftc8inx 7882 17 to to IN cord-010092-uftc8inx 7882 18 false false JJ cord-010092-uftc8inx 7882 19 - - HYPH cord-010092-uftc8inx 7882 20 positive positive JJ cord-010092-uftc8inx 7882 21 results result NNS cord-010092-uftc8inx 7882 22 and and CC cord-010092-uftc8inx 7882 23 donors donor NNS cord-010092-uftc8inx 7882 24 loss loss NN cord-010092-uftc8inx 7882 25 . . . cord-010092-uftc8inx 7883 1 Aims aim VBZ cord-010092-uftc8inx 7883 2 : : : cord-010092-uftc8inx 7884 1 This this DT cord-010092-uftc8inx 7884 2 study study NN cord-010092-uftc8inx 7884 3 intended intend VBD cord-010092-uftc8inx 7884 4 to to TO cord-010092-uftc8inx 7884 5 establish establish VB cord-010092-uftc8inx 7884 6 a a DT cord-010092-uftc8inx 7884 7 donor donor NN cord-010092-uftc8inx 7884 8 reentry reentry NN cord-010092-uftc8inx 7884 9 procedure procedure NN cord-010092-uftc8inx 7884 10 for for IN cord-010092-uftc8inx 7884 11 HCV HCV NNP cord-010092-uftc8inx 7884 12 screening screening NN cord-010092-uftc8inx 7884 13 reactive reactive JJ cord-010092-uftc8inx 7884 14 donors donor NNS cord-010092-uftc8inx 7884 15 in in IN cord-010092-uftc8inx 7884 16 China China NNP cord-010092-uftc8inx 7884 17 . . . cord-010092-uftc8inx 7885 1 Methods method NNS cord-010092-uftc8inx 7885 2 : : : cord-010092-uftc8inx 7886 1 From from IN cord-010092-uftc8inx 7886 2 March March NNP cord-010092-uftc8inx 7886 3 2014 2014 CD cord-010092-uftc8inx 7886 4 to to IN cord-010092-uftc8inx 7886 5 December December NNP cord-010092-uftc8inx 7886 6 2017 2017 CD cord-010092-uftc8inx 7886 7 , , , cord-010092-uftc8inx 7886 8 there there EX cord-010092-uftc8inx 7886 9 were be VBD cord-010092-uftc8inx 7886 10 2083 2083 CD cord-010092-uftc8inx 7886 11 blood blood NN cord-010092-uftc8inx 7886 12 donor donor NN cord-010092-uftc8inx 7886 13 samples sample NNS cord-010092-uftc8inx 7886 14 which which WDT cord-010092-uftc8inx 7886 15 were be VBD cord-010092-uftc8inx 7886 16 screened screen VBN cord-010092-uftc8inx 7886 17 reactive reactive JJ cord-010092-uftc8inx 7886 18 or or CC cord-010092-uftc8inx 7886 19 belonged belong VBD cord-010092-uftc8inx 7886 20 to to IN cord-010092-uftc8inx 7886 21 " " `` cord-010092-uftc8inx 7886 22 grey grey NNP cord-010092-uftc8inx 7886 23 zone zone NN cord-010092-uftc8inx 7886 24 " " '' cord-010092-uftc8inx 7886 25 by by IN cord-010092-uftc8inx 7886 26 ELISA ELISA NNP cord-010092-uftc8inx 7886 27 and/or and/or CC cord-010092-uftc8inx 7886 28 reactive reactive JJ cord-010092-uftc8inx 7886 29 by by IN cord-010092-uftc8inx 7886 30 nucleic nucleic JJ cord-010092-uftc8inx 7886 31 acid acid NN cord-010092-uftc8inx 7886 32 test(NAT test(nat CD cord-010092-uftc8inx 7886 33 ) ) -RRB- cord-010092-uftc8inx 7886 34 at at IN cord-010092-uftc8inx 7886 35 the the DT cord-010092-uftc8inx 7886 36 local local JJ cord-010092-uftc8inx 7886 37 blood blood NN cord-010092-uftc8inx 7886 38 centers center NNS cord-010092-uftc8inx 7886 39 were be VBD cord-010092-uftc8inx 7886 40 collected collect VBN cord-010092-uftc8inx 7886 41 from from IN cord-010092-uftc8inx 7886 42 15 15 CD cord-010092-uftc8inx 7886 43 Chinese chinese JJ cord-010092-uftc8inx 7886 44 blood blood NN cord-010092-uftc8inx 7886 45 centers center NNS cord-010092-uftc8inx 7886 46 . . . cord-010092-uftc8inx 7887 1 All all PDT cord-010092-uftc8inx 7887 2 these these DT cord-010092-uftc8inx 7887 3 samples sample NNS cord-010092-uftc8inx 7887 4 were be VBD cord-010092-uftc8inx 7887 5 sent send VBN cord-010092-uftc8inx 7887 6 to to IN cord-010092-uftc8inx 7887 7 Institute Institute NNP cord-010092-uftc8inx 7887 8 of of IN cord-010092-uftc8inx 7887 9 Blood Blood NNP cord-010092-uftc8inx 7887 10 Transfusion Transfusion NNP cord-010092-uftc8inx 7887 11 ( ( -LRB- cord-010092-uftc8inx 7887 12 IBT IBT NNP cord-010092-uftc8inx 7887 13 ) ) -RRB- cord-010092-uftc8inx 7887 14 national national JJ cord-010092-uftc8inx 7887 15 reference reference NN cord-010092-uftc8inx 7887 16 laboratory laboratory NN cord-010092-uftc8inx 7887 17 where where WRB cord-010092-uftc8inx 7887 18 anti anti JJ cord-010092-uftc8inx 7887 19 - - JJ cord-010092-uftc8inx 7887 20 HCV HCV NNP cord-010092-uftc8inx 7887 21 and and CC cord-010092-uftc8inx 7887 22 HCV HCV NNP cord-010092-uftc8inx 7887 23 individual individual JJ cord-010092-uftc8inx 7887 24 nucleic nucleic JJ cord-010092-uftc8inx 7887 25 acid acid NN cord-010092-uftc8inx 7887 26 test test NN cord-010092-uftc8inx 7887 27 ( ( -LRB- cord-010092-uftc8inx 7887 28 ID ID NNP cord-010092-uftc8inx 7887 29 - - HYPH cord-010092-uftc8inx 7887 30 NAT NAT NNP cord-010092-uftc8inx 7887 31 ) ) -RRB- cord-010092-uftc8inx 7887 32 were be VBD cord-010092-uftc8inx 7887 33 conducted conduct VBN cord-010092-uftc8inx 7887 34 . . . cord-010092-uftc8inx 7888 1 If if IN cord-010092-uftc8inx 7888 2 the the DT cord-010092-uftc8inx 7888 3 results result NNS cord-010092-uftc8inx 7888 4 were be VBD cord-010092-uftc8inx 7888 5 reactive reactive JJ cord-010092-uftc8inx 7888 6 for for IN cord-010092-uftc8inx 7888 7 anti anti JJ cord-010092-uftc8inx 7888 8 - - NNP cord-010092-uftc8inx 7888 9 HCV HCV NNP cord-010092-uftc8inx 7888 10 , , , cord-010092-uftc8inx 7888 11 then then RB cord-010092-uftc8inx 7888 12 the the DT cord-010092-uftc8inx 7888 13 samples sample NNS cord-010092-uftc8inx 7888 14 were be VBD cord-010092-uftc8inx 7888 15 tested test VBN cord-010092-uftc8inx 7888 16 with with IN cord-010092-uftc8inx 7888 17 a a DT cord-010092-uftc8inx 7888 18 Recombinant Recombinant NNP cord-010092-uftc8inx 7888 19 ImmunoBlot ImmunoBlot NNP cord-010092-uftc8inx 7888 20 Assay Assay NNP cord-010092-uftc8inx 7888 21 ( ( -LRB- cord-010092-uftc8inx 7888 22 RIBA RIBA NNP cord-010092-uftc8inx 7888 23 ) ) -RRB- cord-010092-uftc8inx 7888 24 . . . cord-010092-uftc8inx 7889 1 Results result NNS cord-010092-uftc8inx 7889 2 : : : cord-010092-uftc8inx 7890 1 Based base VBN cord-010092-uftc8inx 7890 2 on on IN cord-010092-uftc8inx 7890 3 this this DT cord-010092-uftc8inx 7890 4 study study NN cord-010092-uftc8inx 7890 5 , , , cord-010092-uftc8inx 7890 6 1178 1178 CD cord-010092-uftc8inx 7890 7 of of IN cord-010092-uftc8inx 7890 8 2083 2083 CD cord-010092-uftc8inx 7890 9 donors donor NNS cord-010092-uftc8inx 7890 10 in in IN cord-010092-uftc8inx 7890 11 the the DT cord-010092-uftc8inx 7890 12 study study NN cord-010092-uftc8inx 7890 13 who who WP cord-010092-uftc8inx 7890 14 could could MD cord-010092-uftc8inx 7890 15 be be VB cord-010092-uftc8inx 7890 16 classified classify VBN cord-010092-uftc8inx 7890 17 into into IN cord-010092-uftc8inx 7890 18 two two CD cord-010092-uftc8inx 7890 19 categories category NNS cord-010092-uftc8inx 7890 20 for for IN cord-010092-uftc8inx 7890 21 HCV HCV NNP cord-010092-uftc8inx 7890 22 status status NN cord-010092-uftc8inx 7890 23 : : : cord-010092-uftc8inx 7890 24 201(17.1 201(17.1 CD cord-010092-uftc8inx 7890 25 % % NN cord-010092-uftc8inx 7890 26 ) ) -RRB- cord-010092-uftc8inx 7890 27 true true JJ cord-010092-uftc8inx 7890 28 positive positive JJ cord-010092-uftc8inx 7890 29 and and CC cord-010092-uftc8inx 7890 30 974 974 CD cord-010092-uftc8inx 7890 31 ( ( -LRB- cord-010092-uftc8inx 7890 32 82.9 82.9 CD cord-010092-uftc8inx 7890 33 % % NN cord-010092-uftc8inx 7890 34 ) ) -RRB- cord-010092-uftc8inx 7890 35 false false JJ cord-010092-uftc8inx 7890 36 positive positive JJ cord-010092-uftc8inx 7890 37 . . . cord-010092-uftc8inx 7891 1 A a DT cord-010092-uftc8inx 7891 2 total total NN cord-010092-uftc8inx 7891 3 of of IN cord-010092-uftc8inx 7891 4 905 905 CD cord-010092-uftc8inx 7891 5 of of IN cord-010092-uftc8inx 7891 6 2083 2083 CD cord-010092-uftc8inx 7891 7 donors donor NNS cord-010092-uftc8inx 7891 8 lost lose VBN cord-010092-uftc8inx 7891 9 to to TO cord-010092-uftc8inx 7891 10 follow follow VB cord-010092-uftc8inx 7891 11 - - HYPH cord-010092-uftc8inx 7891 12 up up NN cord-010092-uftc8inx 7891 13 , , , cord-010092-uftc8inx 7891 14 their -PRON- PRP$ cord-010092-uftc8inx 7891 15 HCV HCV NNP cord-010092-uftc8inx 7891 16 status status NN cord-010092-uftc8inx 7891 17 can can MD cord-010092-uftc8inx 7891 18 not not RB cord-010092-uftc8inx 7891 19 be be VB cord-010092-uftc8inx 7891 20 determined determine VBN cord-010092-uftc8inx 7891 21 with with IN cord-010092-uftc8inx 7891 22 certainty certainty NN cord-010092-uftc8inx 7891 23 . . . cord-010092-uftc8inx 7892 1 Based base VBN cord-010092-uftc8inx 7892 2 on on IN cord-010092-uftc8inx 7892 3 these these DT cord-010092-uftc8inx 7892 4 data datum NNS cord-010092-uftc8inx 7892 5 , , , cord-010092-uftc8inx 7892 6 a a DT cord-010092-uftc8inx 7892 7 reentry reentry NN cord-010092-uftc8inx 7892 8 procedure procedure NN cord-010092-uftc8inx 7892 9 for for IN cord-010092-uftc8inx 7892 10 HCV HCV NNP cord-010092-uftc8inx 7892 11 screening screening NN cord-010092-uftc8inx 7892 12 reactive reactive JJ cord-010092-uftc8inx 7892 13 donors donor NNS cord-010092-uftc8inx 7892 14 was be VBD cord-010092-uftc8inx 7892 15 proposed propose VBN cord-010092-uftc8inx 7892 16 . . . cord-010092-uftc8inx 7893 1 Summary Summary NNP cord-010092-uftc8inx 7893 2 / / SYM cord-010092-uftc8inx 7893 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 7893 4 : : : cord-010092-uftc8inx 7894 1 Based base VBN cord-010092-uftc8inx 7894 2 on on IN cord-010092-uftc8inx 7894 3 our -PRON- PRP$ cord-010092-uftc8inx 7894 4 proposed propose VBN cord-010092-uftc8inx 7894 5 donor donor NN cord-010092-uftc8inx 7894 6 reentry reentry NN cord-010092-uftc8inx 7894 7 procedure procedure NN cord-010092-uftc8inx 7894 8 for for IN cord-010092-uftc8inx 7894 9 HCV HCV NNP cord-010092-uftc8inx 7894 10 screening screening NN cord-010092-uftc8inx 7894 11 reactive reactive JJ cord-010092-uftc8inx 7894 12 donors donor NNS cord-010092-uftc8inx 7894 13 , , , cord-010092-uftc8inx 7894 14 a a DT cord-010092-uftc8inx 7894 15 majority majority NN cord-010092-uftc8inx 7894 16 of of IN cord-010092-uftc8inx 7894 17 screening screen VBG cord-010092-uftc8inx 7894 18 false false JJ cord-010092-uftc8inx 7894 19 - - HYPH cord-010092-uftc8inx 7894 20 positive positive JJ cord-010092-uftc8inx 7894 21 donors donor NNS cord-010092-uftc8inx 7894 22 ( ( -LRB- cord-010092-uftc8inx 7894 23 82.9 82.9 CD cord-010092-uftc8inx 7894 24 % % NN cord-010092-uftc8inx 7894 25 ) ) -RRB- cord-010092-uftc8inx 7894 26 can can MD cord-010092-uftc8inx 7894 27 re re VB cord-010092-uftc8inx 7894 28 - - NN cord-010092-uftc8inx 7894 29 entry entry NN cord-010092-uftc8inx 7894 30 safely safely RB cord-010092-uftc8inx 7894 31 . . . cord-010092-uftc8inx 7895 1 Abstract Abstract NNP cord-010092-uftc8inx 7895 2 withdrawn withdraw VBN cord-010092-uftc8inx 7895 3 . . . cord-010092-uftc8inx 7896 1 Background background NN cord-010092-uftc8inx 7896 2 : : : cord-010092-uftc8inx 7897 1 Providing provide VBG cord-010092-uftc8inx 7897 2 safe safe JJ cord-010092-uftc8inx 7897 3 blood blood NN cord-010092-uftc8inx 7897 4 for for IN cord-010092-uftc8inx 7897 5 transfusion transfusion NN cord-010092-uftc8inx 7897 6 in in IN cord-010092-uftc8inx 7897 7 Sub Sub NNP cord-010092-uftc8inx 7897 8 - - HYPH cord-010092-uftc8inx 7897 9 Saharan Saharan NNP cord-010092-uftc8inx 7897 10 Africa Africa NNP cord-010092-uftc8inx 7897 11 ( ( -LRB- cord-010092-uftc8inx 7897 12 SSA SSA NNP cord-010092-uftc8inx 7897 13 ) ) -RRB- cord-010092-uftc8inx 7897 14 is be VBZ cord-010092-uftc8inx 7897 15 a a DT cord-010092-uftc8inx 7897 16 particular particular JJ cord-010092-uftc8inx 7897 17 challenge challenge NN cord-010092-uftc8inx 7897 18 due due IN cord-010092-uftc8inx 7897 19 to to IN cord-010092-uftc8inx 7897 20 a a DT cord-010092-uftc8inx 7897 21 combination combination NN cord-010092-uftc8inx 7897 22 of of IN cord-010092-uftc8inx 7897 23 factors factor NNS cord-010092-uftc8inx 7897 24 ; ; , cord-010092-uftc8inx 7897 25 limited limited JJ cord-010092-uftc8inx 7897 26 resources resource NNS cord-010092-uftc8inx 7897 27 and and CC cord-010092-uftc8inx 7897 28 infrastructure infrastructure NN cord-010092-uftc8inx 7897 29 , , , cord-010092-uftc8inx 7897 30 suboptimal suboptimal JJ cord-010092-uftc8inx 7897 31 diagnostics diagnostic NNS cord-010092-uftc8inx 7897 32 and and CC cord-010092-uftc8inx 7897 33 a a DT cord-010092-uftc8inx 7897 34 high high JJ cord-010092-uftc8inx 7897 35 prevalence prevalence NN cord-010092-uftc8inx 7897 36 of of IN cord-010092-uftc8inx 7897 37 the the DT cord-010092-uftc8inx 7897 38 major major JJ cord-010092-uftc8inx 7897 39 transfusion transfusion NN cord-010092-uftc8inx 7897 40 - - HYPH cord-010092-uftc8inx 7897 41 transmissible transmissible JJ cord-010092-uftc8inx 7897 42 infections infection NNS cord-010092-uftc8inx 7897 43 ( ( -LRB- cord-010092-uftc8inx 7897 44 TTIs tti NNS cord-010092-uftc8inx 7897 45 ) ) -RRB- cord-010092-uftc8inx 7897 46 . . . cord-010092-uftc8inx 7898 1 Average average JJ cord-010092-uftc8inx 7898 2 seroprevalence seroprevalence NN cord-010092-uftc8inx 7898 3 data datum NNS cord-010092-uftc8inx 7898 4 estimates estimate NNS cord-010092-uftc8inx 7898 5 from from IN cord-010092-uftc8inx 7898 6 the the DT cord-010092-uftc8inx 7898 7 Ugandan ugandan JJ cord-010092-uftc8inx 7898 8 and and CC cord-010092-uftc8inx 7898 9 Kenyan Kenyan NNP cord-010092-uftc8inx 7898 10 Blood Blood NNP cord-010092-uftc8inx 7898 11 Transfusion Transfusion NNP cord-010092-uftc8inx 7898 12 Services Services NNP cord-010092-uftc8inx 7898 13 ( ( -LRB- cord-010092-uftc8inx 7898 14 BTS BTS NNP cord-010092-uftc8inx 7898 15 ) ) -RRB- cord-010092-uftc8inx 7898 16 for for IN cord-010092-uftc8inx 7898 17 hepatitis hepatitis NN cord-010092-uftc8inx 7898 18 C C NNP cord-010092-uftc8inx 7898 19 ( ( -LRB- cord-010092-uftc8inx 7898 20 HCV HCV NNP cord-010092-uftc8inx 7898 21 ) ) -RRB- cord-010092-uftc8inx 7898 22 currently currently RB cord-010092-uftc8inx 7898 23 stand stand VBP cord-010092-uftc8inx 7898 24 at at IN cord-010092-uftc8inx 7898 25 6.6 6.6 CD cord-010092-uftc8inx 7898 26 % % NN cord-010092-uftc8inx 7898 27 and and CC cord-010092-uftc8inx 7898 28 0.9 0.9 CD cord-010092-uftc8inx 7898 29 % % NN cord-010092-uftc8inx 7898 30 respectively respectively RB cord-010092-uftc8inx 7898 31 . . . cord-010092-uftc8inx 7899 1 Between between IN cord-010092-uftc8inx 7899 2 January January NNP cord-010092-uftc8inx 7899 3 and and CC cord-010092-uftc8inx 7899 4 December December NNP cord-010092-uftc8inx 7899 5 2016 2016 CD cord-010092-uftc8inx 7899 6 , , , cord-010092-uftc8inx 7899 7 in in IN cord-010092-uftc8inx 7899 8 Mbale Mbale NNP cord-010092-uftc8inx 7899 9 ( ( -LRB- cord-010092-uftc8inx 7899 10 Eastern Eastern NNP cord-010092-uftc8inx 7899 11 Uganda Uganda NNP cord-010092-uftc8inx 7899 12 ) ) -RRB- cord-010092-uftc8inx 7900 1 the the DT cord-010092-uftc8inx 7900 2 HCV HCV NNP cord-010092-uftc8inx 7900 3 prevalence prevalence NN cord-010092-uftc8inx 7900 4 amongst amongst IN cord-010092-uftc8inx 7900 5 blood blood NN cord-010092-uftc8inx 7900 6 donors donor NNS cord-010092-uftc8inx 7900 7 was be VBD cord-010092-uftc8inx 7900 8 an an DT cord-010092-uftc8inx 7900 9 alarming alarming JJ cord-010092-uftc8inx 7900 10 8.1 8.1 CD cord-010092-uftc8inx 7900 11 % % NN cord-010092-uftc8inx 7900 12 . . . cord-010092-uftc8inx 7901 1 With with IN cord-010092-uftc8inx 7901 2 no no DT cord-010092-uftc8inx 7901 3 provision provision NN cord-010092-uftc8inx 7901 4 or or CC cord-010092-uftc8inx 7901 5 funds fund NNS cord-010092-uftc8inx 7901 6 for for IN cord-010092-uftc8inx 7901 7 confirmatory confirmatory JJ cord-010092-uftc8inx 7901 8 testing testing NN cord-010092-uftc8inx 7901 9 , , , cord-010092-uftc8inx 7901 10 the the DT cord-010092-uftc8inx 7901 11 BTS BTS NNP cord-010092-uftc8inx 7901 12 are be VBP cord-010092-uftc8inx 7901 13 unable unable JJ cord-010092-uftc8inx 7901 14 to to TO cord-010092-uftc8inx 7901 15 confirm confirm VB cord-010092-uftc8inx 7901 16 or or CC cord-010092-uftc8inx 7901 17 refute refute VB cord-010092-uftc8inx 7901 18 a a DT cord-010092-uftc8inx 7901 19 diagnosis diagnosis NN cord-010092-uftc8inx 7901 20 of of IN cord-010092-uftc8inx 7901 21 active active JJ cord-010092-uftc8inx 7901 22 HCV HCV NNP cord-010092-uftc8inx 7901 23 . . . cord-010092-uftc8inx 7902 1 This this DT cord-010092-uftc8inx 7902 2 results result VBZ cord-010092-uftc8inx 7902 3 in in IN cord-010092-uftc8inx 7902 4 large large JJ cord-010092-uftc8inx 7902 5 quantities quantity NNS cord-010092-uftc8inx 7902 6 of of IN cord-010092-uftc8inx 7902 7 blood blood NN cord-010092-uftc8inx 7902 8 wastage wastage NN cord-010092-uftc8inx 7902 9 , , , cord-010092-uftc8inx 7902 10 unnecessary unnecessary JJ cord-010092-uftc8inx 7902 11 anxiety anxiety NN cord-010092-uftc8inx 7902 12 in in IN cord-010092-uftc8inx 7902 13 potential potential JJ cord-010092-uftc8inx 7902 14 donors donor NNS cord-010092-uftc8inx 7902 15 and and CC cord-010092-uftc8inx 7902 16 high high JJ cord-010092-uftc8inx 7902 17 donor donor NN cord-010092-uftc8inx 7902 18 deferral deferral NN cord-010092-uftc8inx 7902 19 rates rate NNS cord-010092-uftc8inx 7902 20 limiting limit VBG cord-010092-uftc8inx 7902 21 the the DT cord-010092-uftc8inx 7902 22 donor donor NN cord-010092-uftc8inx 7902 23 pool pool NN cord-010092-uftc8inx 7902 24 . . . cord-010092-uftc8inx 7903 1 Aims aim VBZ cord-010092-uftc8inx 7903 2 : : : cord-010092-uftc8inx 7904 1 We -PRON- PRP cord-010092-uftc8inx 7904 2 aim aim VBP cord-010092-uftc8inx 7904 3 to to TO cord-010092-uftc8inx 7904 4 determine determine VB cord-010092-uftc8inx 7904 5 the the DT cord-010092-uftc8inx 7904 6 true true JJ cord-010092-uftc8inx 7904 7 prevalence prevalence NN cord-010092-uftc8inx 7904 8 of of IN cord-010092-uftc8inx 7904 9 active active JJ cord-010092-uftc8inx 7904 10 HCV HCV NNP cord-010092-uftc8inx 7904 11 infection infection NN cord-010092-uftc8inx 7904 12 amongst amongst IN cord-010092-uftc8inx 7904 13 seropositive seropositive JJ cord-010092-uftc8inx 7904 14 donors donor NNS cord-010092-uftc8inx 7904 15 in in IN cord-010092-uftc8inx 7904 16 BTS BTS NNP cord-010092-uftc8inx 7904 17 in in IN cord-010092-uftc8inx 7904 18 Uganda Uganda NNP cord-010092-uftc8inx 7904 19 and and CC cord-010092-uftc8inx 7904 20 Kenya Kenya NNP cord-010092-uftc8inx 7904 21 . . . cord-010092-uftc8inx 7905 1 In in IN cord-010092-uftc8inx 7905 2 addition addition NN cord-010092-uftc8inx 7905 3 , , , cord-010092-uftc8inx 7905 4 we -PRON- PRP cord-010092-uftc8inx 7905 5 aim aim VBP cord-010092-uftc8inx 7905 6 to to TO cord-010092-uftc8inx 7905 7 compare compare VB cord-010092-uftc8inx 7905 8 the the DT cord-010092-uftc8inx 7905 9 performance performance NN cord-010092-uftc8inx 7905 10 of of IN cord-010092-uftc8inx 7905 11 locally locally RB cord-010092-uftc8inx 7905 12 used use VBN cord-010092-uftc8inx 7905 13 serodiagnostics serodiagnostic NNS cord-010092-uftc8inx 7905 14 and and CC cord-010092-uftc8inx 7905 15 best well RBS cord-010092-uftc8inx 7905 16 available available JJ cord-010092-uftc8inx 7905 17 alternative alternative JJ cord-010092-uftc8inx 7905 18 tests test NNS cord-010092-uftc8inx 7905 19 and and CC cord-010092-uftc8inx 7905 20 to to TO cord-010092-uftc8inx 7905 21 examine examine VB cord-010092-uftc8inx 7905 22 the the DT cord-010092-uftc8inx 7905 23 feasibility feasibility NN cord-010092-uftc8inx 7905 24 of of IN cord-010092-uftc8inx 7905 25 cost cost NN cord-010092-uftc8inx 7905 26 - - HYPH cord-010092-uftc8inx 7905 27 effective effective JJ cord-010092-uftc8inx 7905 28 additional additional JJ cord-010092-uftc8inx 7905 29 or or CC cord-010092-uftc8inx 7905 30 alternative alternative JJ cord-010092-uftc8inx 7905 31 tests test NNS cord-010092-uftc8inx 7905 32 to to TO cord-010092-uftc8inx 7905 33 help help VB cord-010092-uftc8inx 7905 34 provide provide VB cord-010092-uftc8inx 7905 35 accurate accurate JJ cord-010092-uftc8inx 7905 36 results result NNS cord-010092-uftc8inx 7905 37 on on IN cord-010092-uftc8inx 7905 38 the the DT cord-010092-uftc8inx 7905 39 infectious infectious JJ cord-010092-uftc8inx 7905 40 status status NN cord-010092-uftc8inx 7905 41 of of IN cord-010092-uftc8inx 7905 42 blood blood NN cord-010092-uftc8inx 7905 43 . . . cord-010092-uftc8inx 7906 1 Methods method NNS cord-010092-uftc8inx 7906 2 : : : cord-010092-uftc8inx 7906 3 235 235 CD cord-010092-uftc8inx 7906 4 HCV HCV NNP cord-010092-uftc8inx 7906 5 seropositive seropositive JJ cord-010092-uftc8inx 7906 6 blood blood NN cord-010092-uftc8inx 7906 7 samples sample NNS cord-010092-uftc8inx 7906 8 from from IN cord-010092-uftc8inx 7906 9 3 3 CD cord-010092-uftc8inx 7906 10 BTS BTS NNP cord-010092-uftc8inx 7906 11 study study NN cord-010092-uftc8inx 7906 12 sites site NNS cord-010092-uftc8inx 7906 13 ( ( -LRB- cord-010092-uftc8inx 7906 14 Kampala Kampala NNP cord-010092-uftc8inx 7906 15 , , , cord-010092-uftc8inx 7906 16 Mbale Mbale NNP cord-010092-uftc8inx 7906 17 , , , cord-010092-uftc8inx 7906 18 Mombasa Mombasa NNP cord-010092-uftc8inx 7906 19 ) ) -RRB- cord-010092-uftc8inx 7906 20 will will MD cord-010092-uftc8inx 7906 21 be be VB cord-010092-uftc8inx 7906 22 re re VBN cord-010092-uftc8inx 7906 23 - - VBN cord-010092-uftc8inx 7906 24 tested test VBN cord-010092-uftc8inx 7906 25 using use VBG cord-010092-uftc8inx 7906 26 the the DT cord-010092-uftc8inx 7906 27 local local JJ cord-010092-uftc8inx 7906 28 serology serology NN cord-010092-uftc8inx 7906 29 screening screening NN cord-010092-uftc8inx 7906 30 test test NN cord-010092-uftc8inx 7906 31 ( ( -LRB- cord-010092-uftc8inx 7906 32 Abbott Abbott NNP cord-010092-uftc8inx 7906 33 Architect Architect NNP cord-010092-uftc8inx 7906 34 anti anti JJ cord-010092-uftc8inx 7906 35 - - NNP cord-010092-uftc8inx 7906 36 HCV HCV NNP cord-010092-uftc8inx 7906 37 ) ) -RRB- cord-010092-uftc8inx 7906 38 , , , cord-010092-uftc8inx 7906 39 an an DT cord-010092-uftc8inx 7906 40 alternative alternative NN cord-010092-uftc8inx 7906 41 WHO WHO NNP cord-010092-uftc8inx 7906 42 pre pre JJ cord-010092-uftc8inx 7906 43 - - JJ cord-010092-uftc8inx 7906 44 qualified qualified JJ cord-010092-uftc8inx 7906 45 rapid rapid JJ cord-010092-uftc8inx 7906 46 antibody antibody NN cord-010092-uftc8inx 7906 47 test test NN cord-010092-uftc8inx 7906 48 ( ( -LRB- cord-010092-uftc8inx 7906 49 SD SD NNP cord-010092-uftc8inx 7906 50 Bioline Bioline NNP cord-010092-uftc8inx 7906 51 ) ) -RRB- cord-010092-uftc8inx 7906 52 and and CC cord-010092-uftc8inx 7906 53 a a DT cord-010092-uftc8inx 7906 54 confirmatory confirmatory JJ cord-010092-uftc8inx 7906 55 test test NN cord-010092-uftc8inx 7906 56 ( ( -LRB- cord-010092-uftc8inx 7906 57 HCV HCV NNP cord-010092-uftc8inx 7906 58 core core NN cord-010092-uftc8inx 7906 59 antigen antigen NN cord-010092-uftc8inx 7906 60 test test NN cord-010092-uftc8inx 7906 61 ) ) -RRB- cord-010092-uftc8inx 7906 62 . . . cord-010092-uftc8inx 7907 1 Where where WRB cord-010092-uftc8inx 7907 2 there there EX cord-010092-uftc8inx 7907 3 is be VBZ cord-010092-uftc8inx 7907 4 discrepancy discrepancy NN cord-010092-uftc8inx 7907 5 in in IN cord-010092-uftc8inx 7907 6 the the DT cord-010092-uftc8inx 7907 7 results result NNS cord-010092-uftc8inx 7907 8 or or CC cord-010092-uftc8inx 7907 9 need need NN cord-010092-uftc8inx 7907 10 for for IN cord-010092-uftc8inx 7907 11 clarification clarification NN cord-010092-uftc8inx 7907 12 , , , cord-010092-uftc8inx 7907 13 samples sample NNS cord-010092-uftc8inx 7907 14 will will MD cord-010092-uftc8inx 7907 15 be be VB cord-010092-uftc8inx 7907 16 tested test VBN cord-010092-uftc8inx 7907 17 on on IN cord-010092-uftc8inx 7907 18 the the DT cord-010092-uftc8inx 7907 19 Cepheid Cepheid NNP cord-010092-uftc8inx 7907 20 Xpert Xpert NNP cord-010092-uftc8inx 7907 21 platform platform NN cord-010092-uftc8inx 7907 22 by by IN cord-010092-uftc8inx 7907 23 reverse reverse NN cord-010092-uftc8inx 7907 24 - - HYPH cord-010092-uftc8inx 7907 25 transcriptase transcriptase NN cord-010092-uftc8inx 7907 26 PCR PCR NNP cord-010092-uftc8inx 7907 27 to to TO cord-010092-uftc8inx 7907 28 obtain obtain VB cord-010092-uftc8inx 7907 29 a a DT cord-010092-uftc8inx 7907 30 quantitative quantitative JJ cord-010092-uftc8inx 7907 31 RNA RNA NNP cord-010092-uftc8inx 7907 32 result result NN cord-010092-uftc8inx 7907 33 . . . cord-010092-uftc8inx 7908 1 S S NNP cord-010092-uftc8inx 7908 2 / / SYM cord-010092-uftc8inx 7908 3 CO CO NNP cord-010092-uftc8inx 7908 4 ( ( -LRB- cord-010092-uftc8inx 7908 5 specimen specimen JJ cord-010092-uftc8inx 7908 6 to to TO cord-010092-uftc8inx 7908 7 cut cut VB cord-010092-uftc8inx 7908 8 - - HYPH cord-010092-uftc8inx 7908 9 off off RP cord-010092-uftc8inx 7908 10 ) ) -RRB- cord-010092-uftc8inx 7908 11 values value NNS cord-010092-uftc8inx 7908 12 for for IN cord-010092-uftc8inx 7908 13 false false JJ cord-010092-uftc8inx 7908 14 positive positive JJ cord-010092-uftc8inx 7908 15 samples sample NNS cord-010092-uftc8inx 7908 16 ( ( -LRB- cord-010092-uftc8inx 7908 17 by by IN cord-010092-uftc8inx 7908 18 screening screen VBG cord-010092-uftc8inx 7908 19 serology serology NN cord-010092-uftc8inx 7908 20 ) ) -RRB- cord-010092-uftc8inx 7908 21 will will MD cord-010092-uftc8inx 7908 22 be be VB cord-010092-uftc8inx 7908 23 analysed analyse VBN cord-010092-uftc8inx 7908 24 and and CC cord-010092-uftc8inx 7908 25 presented present VBN cord-010092-uftc8inx 7908 26 . . . cord-010092-uftc8inx 7909 1 Pre pre JJ cord-010092-uftc8inx 7909 2 - - JJ cord-010092-uftc8inx 7909 3 analytical analytical JJ cord-010092-uftc8inx 7909 4 factors factor NNS cord-010092-uftc8inx 7909 5 ( ( -LRB- cord-010092-uftc8inx 7909 6 centrifugation centrifugation NN cord-010092-uftc8inx 7909 7 speed speed NN cord-010092-uftc8inx 7909 8 , , , cord-010092-uftc8inx 7909 9 haemolysis haemolysis NN cord-010092-uftc8inx 7909 10 check check NN cord-010092-uftc8inx 7909 11 , , , cord-010092-uftc8inx 7909 12 time time NN cord-010092-uftc8inx 7909 13 delay delay NN cord-010092-uftc8inx 7909 14 between between IN cord-010092-uftc8inx 7909 15 collection collection NN cord-010092-uftc8inx 7909 16 and and CC cord-010092-uftc8inx 7909 17 testing testing NN cord-010092-uftc8inx 7909 18 ) ) -RRB- cord-010092-uftc8inx 7909 19 will will MD cord-010092-uftc8inx 7909 20 be be VB cord-010092-uftc8inx 7909 21 controlled control VBN cord-010092-uftc8inx 7909 22 for for IN cord-010092-uftc8inx 7909 23 and and CC cord-010092-uftc8inx 7909 24 documented document VBN cord-010092-uftc8inx 7909 25 . . . cord-010092-uftc8inx 7910 1 Results result NNS cord-010092-uftc8inx 7910 2 : : : cord-010092-uftc8inx 7911 1 Pilot pilot NN cord-010092-uftc8inx 7911 2 data datum NNS cord-010092-uftc8inx 7911 3 from from IN cord-010092-uftc8inx 7911 4 re re NN cord-010092-uftc8inx 7911 5 - - NN cord-010092-uftc8inx 7911 6 testing testing NN cord-010092-uftc8inx 7911 7 quarantined quarantine VBD cord-010092-uftc8inx 7911 8 HCV HCV NNP cord-010092-uftc8inx 7911 9 seropositive seropositive JJ cord-010092-uftc8inx 7911 10 donor donor NN cord-010092-uftc8inx 7911 11 blood blood NN cord-010092-uftc8inx 7911 12 ( ( -LRB- cord-010092-uftc8inx 7911 13 Mbale Mbale NNP cord-010092-uftc8inx 7911 14 BTS BTS NNP cord-010092-uftc8inx 7911 15 ) ) -RRB- cord-010092-uftc8inx 7911 16 in in IN cord-010092-uftc8inx 7911 17 Uganda Uganda NNP cord-010092-uftc8inx 7911 18 demonstrated demonstrate VBD cord-010092-uftc8inx 7911 19 that that IN cord-010092-uftc8inx 7911 20 45/50 45/50 CD cord-010092-uftc8inx 7911 21 seropositive seropositive JJ cord-010092-uftc8inx 7911 22 blood blood NN cord-010092-uftc8inx 7911 23 ( ( -LRB- cord-010092-uftc8inx 7911 24 90 90 CD cord-010092-uftc8inx 7911 25 % % NN cord-010092-uftc8inx 7911 26 ) ) -RRB- cord-010092-uftc8inx 7911 27 was be VBD cord-010092-uftc8inx 7911 28 RNA RNA NNP cord-010092-uftc8inx 7911 29 PCR PCR NNP cord-010092-uftc8inx 7911 30 negative negative JJ cord-010092-uftc8inx 7911 31 . . . cord-010092-uftc8inx 7912 1 In in IN cord-010092-uftc8inx 7912 2 December December NNP cord-010092-uftc8inx 7912 3 2018 2018 CD cord-010092-uftc8inx 7912 4 , , , cord-010092-uftc8inx 7912 5 156/249 156/249 NNP cord-010092-uftc8inx 7912 6 ( ( -LRB- cord-010092-uftc8inx 7912 7 63 63 CD cord-010092-uftc8inx 7912 8 % % NN cord-010092-uftc8inx 7912 9 ) ) -RRB- cord-010092-uftc8inx 7912 10 of of IN cord-010092-uftc8inx 7912 11 seropositive seropositive JJ cord-010092-uftc8inx 7912 12 samples sample NNS cord-010092-uftc8inx 7912 13 ( ( -LRB- cord-010092-uftc8inx 7912 14 by by IN cord-010092-uftc8inx 7912 15 screening screen VBG cord-010092-uftc8inx 7912 16 anti anti JJ cord-010092-uftc8inx 7912 17 - - JJ cord-010092-uftc8inx 7912 18 HCV hcv JJ cord-010092-uftc8inx 7912 19 serology serology NN cord-010092-uftc8inx 7912 20 ) ) -RRB- cord-010092-uftc8inx 7912 21 in in IN cord-010092-uftc8inx 7912 22 Kampala Kampala NNP cord-010092-uftc8inx 7912 23 BTS BTS NNP cord-010092-uftc8inx 7912 24 had have VBD cord-010092-uftc8inx 7912 25 S S NNP cord-010092-uftc8inx 7912 26 / / SYM cord-010092-uftc8inx 7912 27 CO co NN cord-010092-uftc8inx 7912 28 values value NNS cord-010092-uftc8inx 7912 29 between between IN cord-010092-uftc8inx 7912 30 1.00 1.00 CD cord-010092-uftc8inx 7912 31 - - SYM cord-010092-uftc8inx 7912 32 1.99 1.99 CD cord-010092-uftc8inx 7912 33 ( ( -LRB- cord-010092-uftc8inx 7912 34 1.00 1.00 CD cord-010092-uftc8inx 7912 35 is be VBZ cord-010092-uftc8inx 7912 36 the the DT cord-010092-uftc8inx 7912 37 cut cut VBN cord-010092-uftc8inx 7912 38 - - HYPH cord-010092-uftc8inx 7912 39 off off NN cord-010092-uftc8inx 7912 40 indicating indicate VBG cord-010092-uftc8inx 7912 41 a a DT cord-010092-uftc8inx 7912 42 positive positive JJ cord-010092-uftc8inx 7912 43 sample sample NN cord-010092-uftc8inx 7912 44 ) ) -RRB- cord-010092-uftc8inx 7912 45 . . . cord-010092-uftc8inx 7913 1 Data datum NNS cord-010092-uftc8inx 7913 2 from from IN cord-010092-uftc8inx 7913 3 the the DT cord-010092-uftc8inx 7913 4 re re NN cord-010092-uftc8inx 7913 5 - - NN cord-010092-uftc8inx 7913 6 testing testing NN cord-010092-uftc8inx 7913 7 of of IN cord-010092-uftc8inx 7913 8 235 235 CD cord-010092-uftc8inx 7913 9 seropositive seropositive JJ cord-010092-uftc8inx 7913 10 samples sample NNS cord-010092-uftc8inx 7913 11 as as IN cord-010092-uftc8inx 7913 12 true true JJ cord-010092-uftc8inx 7913 13 representation representation NN cord-010092-uftc8inx 7913 14 of of IN cord-010092-uftc8inx 7913 15 active active JJ cord-010092-uftc8inx 7913 16 HCV HCV NNP cord-010092-uftc8inx 7913 17 will will MD cord-010092-uftc8inx 7913 18 be be VB cord-010092-uftc8inx 7913 19 demonstrated demonstrate VBN cord-010092-uftc8inx 7913 20 and and CC cord-010092-uftc8inx 7913 21 S S NNP cord-010092-uftc8inx 7913 22 / / SYM cord-010092-uftc8inx 7913 23 CO co NN cord-010092-uftc8inx 7913 24 values value NNS cord-010092-uftc8inx 7913 25 for for IN cord-010092-uftc8inx 7913 26 the the DT cord-010092-uftc8inx 7913 27 study study NN cord-010092-uftc8inx 7913 28 period period NN cord-010092-uftc8inx 7913 29 concomitantly concomitantly RB cord-010092-uftc8inx 7913 30 with with IN cord-010092-uftc8inx 7913 31 a a DT cord-010092-uftc8inx 7913 32 retrospective retrospective JJ cord-010092-uftc8inx 7913 33 analysis analysis NN cord-010092-uftc8inx 7913 34 of of IN cord-010092-uftc8inx 7913 35 January January NNP cord-010092-uftc8inx 7913 36 to to IN cord-010092-uftc8inx 7913 37 December December NNP cord-010092-uftc8inx 7913 38 2018 2018 CD cord-010092-uftc8inx 7913 39 . . . cord-010092-uftc8inx 7914 1 Preanalytical preanalytical JJ cord-010092-uftc8inx 7914 2 factors factor NNS cord-010092-uftc8inx 7914 3 , , , cord-010092-uftc8inx 7914 4 cost cost NN cord-010092-uftc8inx 7914 5 analysis analysis NN cord-010092-uftc8inx 7914 6 comparisons comparison NNS cord-010092-uftc8inx 7914 7 of of IN cord-010092-uftc8inx 7914 8 the the DT cord-010092-uftc8inx 7914 9 diagnostic diagnostic JJ cord-010092-uftc8inx 7914 10 platforms platform NNS cord-010092-uftc8inx 7914 11 coupled couple VBN cord-010092-uftc8inx 7914 12 with with IN cord-010092-uftc8inx 7914 13 costs cost NNS cord-010092-uftc8inx 7914 14 of of IN cord-010092-uftc8inx 7914 15 the the DT cord-010092-uftc8inx 7914 16 donor donor NN cord-010092-uftc8inx 7914 17 deferral deferral NN cord-010092-uftc8inx 7914 18 process process NN cord-010092-uftc8inx 7914 19 in in IN cord-010092-uftc8inx 7914 20 false false JJ cord-010092-uftc8inx 7914 21 positive positive JJ cord-010092-uftc8inx 7914 22 cases case NNS cord-010092-uftc8inx 7914 23 will will MD cord-010092-uftc8inx 7914 24 be be VB cord-010092-uftc8inx 7914 25 presented present VBN cord-010092-uftc8inx 7914 26 . . . cord-010092-uftc8inx 7915 1 Summary Summary NNP cord-010092-uftc8inx 7915 2 / / SYM cord-010092-uftc8inx 7915 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 7915 4 : : : cord-010092-uftc8inx 7916 1 For for IN cord-010092-uftc8inx 7916 2 the the DT cord-010092-uftc8inx 7916 3 BTS BTS NNP cord-010092-uftc8inx 7916 4 in in IN cord-010092-uftc8inx 7916 5 SSA SSA NNP cord-010092-uftc8inx 7916 6 there there EX cord-010092-uftc8inx 7916 7 are be VBP cord-010092-uftc8inx 7916 8 significant significant JJ cord-010092-uftc8inx 7916 9 resource resource NN cord-010092-uftc8inx 7916 10 and and CC cord-010092-uftc8inx 7916 11 financial financial JJ cord-010092-uftc8inx 7916 12 implications implication NNS cord-010092-uftc8inx 7916 13 , , , cord-010092-uftc8inx 7916 14 as as IN cord-010092-uftc8inx 7916 15 repeat repeat NN cord-010092-uftc8inx 7916 16 testing testing NN cord-010092-uftc8inx 7916 17 and and CC cord-010092-uftc8inx 7916 18 donor donor NN cord-010092-uftc8inx 7916 19 deferral deferral NN cord-010092-uftc8inx 7916 20 counselling counselling NN cord-010092-uftc8inx 7916 21 is be VBZ cord-010092-uftc8inx 7916 22 required require VBN cord-010092-uftc8inx 7916 23 . . . cord-010092-uftc8inx 7917 1 Evaluating evaluate VBG cord-010092-uftc8inx 7917 2 and and CC cord-010092-uftc8inx 7917 3 introducing introduce VBG cord-010092-uftc8inx 7917 4 new new JJ cord-010092-uftc8inx 7917 5 and and CC cord-010092-uftc8inx 7917 6 appropriate appropriate JJ cord-010092-uftc8inx 7917 7 diagnostics diagnostic NNS cord-010092-uftc8inx 7917 8 and and CC cord-010092-uftc8inx 7917 9 algorithms algorithm NNS cord-010092-uftc8inx 7917 10 in in IN cord-010092-uftc8inx 7917 11 the the DT cord-010092-uftc8inx 7917 12 screening screening NN cord-010092-uftc8inx 7917 13 of of IN cord-010092-uftc8inx 7917 14 HCV HCV NNP cord-010092-uftc8inx 7917 15 is be VBZ cord-010092-uftc8inx 7917 16 crucial crucial JJ cord-010092-uftc8inx 7917 17 in in IN cord-010092-uftc8inx 7917 18 improving improve VBG cord-010092-uftc8inx 7917 19 the the DT cord-010092-uftc8inx 7917 20 supply supply NN cord-010092-uftc8inx 7917 21 of of IN cord-010092-uftc8inx 7917 22 safe safe JJ cord-010092-uftc8inx 7917 23 blood blood NN cord-010092-uftc8inx 7917 24 transfusion transfusion NN cord-010092-uftc8inx 7917 25 services service NNS cord-010092-uftc8inx 7917 26 in in IN cord-010092-uftc8inx 7917 27 East East NNP cord-010092-uftc8inx 7917 28 Africa Africa NNP cord-010092-uftc8inx 7917 29 . . . cord-010092-uftc8inx 7918 1 Background background NN cord-010092-uftc8inx 7918 2 : : : cord-010092-uftc8inx 7919 1 In in IN cord-010092-uftc8inx 7919 2 November November NNP cord-010092-uftc8inx 7919 3 2017 2017 CD cord-010092-uftc8inx 7919 4 , , , cord-010092-uftc8inx 7919 5 the the DT cord-010092-uftc8inx 7919 6 Blood Blood NNP cord-010092-uftc8inx 7919 7 Services Services NNPS cord-010092-uftc8inx 7919 8 of of IN cord-010092-uftc8inx 7919 9 England England NNP cord-010092-uftc8inx 7919 10 , , , cord-010092-uftc8inx 7919 11 Scotland Scotland NNP cord-010092-uftc8inx 7919 12 and and CC cord-010092-uftc8inx 7919 13 Wales Wales NNP cord-010092-uftc8inx 7919 14 reduced reduce VBD cord-010092-uftc8inx 7919 15 donor donor NN cord-010092-uftc8inx 7919 16 deferral deferral NN cord-010092-uftc8inx 7919 17 to to IN cord-010092-uftc8inx 7919 18 three three CD cord-010092-uftc8inx 7919 19 - - HYPH cord-010092-uftc8inx 7919 20 months month NNS cord-010092-uftc8inx 7919 21 for for IN cord-010092-uftc8inx 7919 22 commercial commercial JJ cord-010092-uftc8inx 7919 23 sex sex NN cord-010092-uftc8inx 7919 24 workers worker NNS cord-010092-uftc8inx 7919 25 and and CC cord-010092-uftc8inx 7919 26 individuals individual NNS cord-010092-uftc8inx 7919 27 with with IN cord-010092-uftc8inx 7919 28 higher high JJR cord-010092-uftc8inx 7919 29 risk risk NN cord-010092-uftc8inx 7919 30 sexual sexual JJ cord-010092-uftc8inx 7919 31 partners partner NNS cord-010092-uftc8inx 7919 32 , , , cord-010092-uftc8inx 7919 33 including include VBG cord-010092-uftc8inx 7919 34 sex sex NN cord-010092-uftc8inx 7919 35 between between IN cord-010092-uftc8inx 7919 36 men man NNS cord-010092-uftc8inx 7919 37 . . . cord-010092-uftc8inx 7920 1 The the DT cord-010092-uftc8inx 7920 2 change change NN cord-010092-uftc8inx 7920 3 was be VBD cord-010092-uftc8inx 7920 4 recommended recommend VBN cord-010092-uftc8inx 7920 5 after after IN cord-010092-uftc8inx 7920 6 a a DT cord-010092-uftc8inx 7920 7 detailed detailed JJ cord-010092-uftc8inx 7920 8 review review NN cord-010092-uftc8inx 7920 9 by by IN cord-010092-uftc8inx 7920 10 an an DT cord-010092-uftc8inx 7920 11 external external JJ cord-010092-uftc8inx 7920 12 expert expert NN cord-010092-uftc8inx 7920 13 committee committee NN cord-010092-uftc8inx 7920 14 ( ( -LRB- cord-010092-uftc8inx 7920 15 SaBTO SaBTO NNP cord-010092-uftc8inx 7920 16 ) ) -RRB- cord-010092-uftc8inx 7920 17 which which WDT cord-010092-uftc8inx 7920 18 recommended recommend VBD cord-010092-uftc8inx 7920 19 that that IN cord-010092-uftc8inx 7920 20 a a DT cord-010092-uftc8inx 7920 21 shortened shorten VBN cord-010092-uftc8inx 7920 22 deferral deferral NN cord-010092-uftc8inx 7920 23 of of IN cord-010092-uftc8inx 7920 24 3 3 CD cord-010092-uftc8inx 7920 25 months month NNS cord-010092-uftc8inx 7920 26 would would MD cord-010092-uftc8inx 7920 27 allow allow VB cord-010092-uftc8inx 7920 28 detection detection NN cord-010092-uftc8inx 7920 29 of of IN cord-010092-uftc8inx 7920 30 recently recently RB cord-010092-uftc8inx 7920 31 acquired acquire VBN cord-010092-uftc8inx 7920 32 infection infection NN cord-010092-uftc8inx 7920 33 and and CC cord-010092-uftc8inx 7920 34 maintain maintain VB cord-010092-uftc8inx 7920 35 residual residual JJ cord-010092-uftc8inx 7920 36 risk risk NN cord-010092-uftc8inx 7920 37 ( ( -LRB- cord-010092-uftc8inx 7920 38 RR rr NN cord-010092-uftc8inx 7920 39 ) ) -RRB- cord-010092-uftc8inx 7920 40 at at IN cord-010092-uftc8inx 7920 41 a a DT cord-010092-uftc8inx 7920 42 tolerable tolerable JJ cord-010092-uftc8inx 7920 43 level level NN cord-010092-uftc8inx 7920 44 . . . cord-010092-uftc8inx 7921 1 Recommendations recommendation NNS cord-010092-uftc8inx 7921 2 were be VBD cord-010092-uftc8inx 7921 3 accepted accept VBN cord-010092-uftc8inx 7921 4 by by IN cord-010092-uftc8inx 7921 5 government government NN cord-010092-uftc8inx 7921 6 but but CC cord-010092-uftc8inx 7921 7 with with IN cord-010092-uftc8inx 7921 8 a a DT cord-010092-uftc8inx 7921 9 government government NN cord-010092-uftc8inx 7921 10 commitment commitment NN cord-010092-uftc8inx 7921 11 to to TO cord-010092-uftc8inx 7921 12 explore explore VB cord-010092-uftc8inx 7921 13 a a DT cord-010092-uftc8inx 7921 14 more more RBR cord-010092-uftc8inx 7921 15 individualised individualised JJ cord-010092-uftc8inx 7921 16 approach approach NN cord-010092-uftc8inx 7921 17 . . . cord-010092-uftc8inx 7922 1 Aims aim VBZ cord-010092-uftc8inx 7922 2 : : : cord-010092-uftc8inx 7922 3 To to TO cord-010092-uftc8inx 7922 4 assess assess VB cord-010092-uftc8inx 7922 5 the the DT cord-010092-uftc8inx 7922 6 impact impact NN cord-010092-uftc8inx 7922 7 of of IN cord-010092-uftc8inx 7922 8 a a DT cord-010092-uftc8inx 7922 9 3-month 3-month CD cord-010092-uftc8inx 7922 10 deferral deferral NN cord-010092-uftc8inx 7922 11 on on IN cord-010092-uftc8inx 7922 12 blood blood NN cord-010092-uftc8inx 7922 13 safety safety NN cord-010092-uftc8inx 7922 14 in in IN cord-010092-uftc8inx 7922 15 terms term NNS cord-010092-uftc8inx 7922 16 of of IN cord-010092-uftc8inx 7922 17 epidemiology epidemiology NN cord-010092-uftc8inx 7922 18 of of IN cord-010092-uftc8inx 7922 19 infections infection NNS cord-010092-uftc8inx 7922 20 in in IN cord-010092-uftc8inx 7922 21 blood blood NN cord-010092-uftc8inx 7922 22 donors donor NNS cord-010092-uftc8inx 7922 23 and and CC cord-010092-uftc8inx 7922 24 compliance compliance NN cord-010092-uftc8inx 7922 25 with with IN cord-010092-uftc8inx 7922 26 donor donor NN cord-010092-uftc8inx 7922 27 selection selection NN cord-010092-uftc8inx 7922 28 criteria criterion NNS cord-010092-uftc8inx 7922 29 , , , cord-010092-uftc8inx 7922 30 and and CC cord-010092-uftc8inx 7922 31 to to TO cord-010092-uftc8inx 7922 32 explore explore VB cord-010092-uftc8inx 7922 33 evidence evidence NN cord-010092-uftc8inx 7922 34 required require VBN cord-010092-uftc8inx 7922 35 to to TO cord-010092-uftc8inx 7922 36 develop develop VB cord-010092-uftc8inx 7922 37 a a DT cord-010092-uftc8inx 7922 38 more more RBR cord-010092-uftc8inx 7922 39 individualised individualised JJ cord-010092-uftc8inx 7922 40 approach approach NN cord-010092-uftc8inx 7922 41 to to IN cord-010092-uftc8inx 7922 42 donor donor NN cord-010092-uftc8inx 7922 43 selection selection NN cord-010092-uftc8inx 7922 44 policy policy NN cord-010092-uftc8inx 7922 45 Methods method NNS cord-010092-uftc8inx 7922 46 : : : cord-010092-uftc8inx 7922 47 Routine routine JJ cord-010092-uftc8inx 7922 48 UK UK NNP cord-010092-uftc8inx 7922 49 blood blood NN cord-010092-uftc8inx 7922 50 donation donation NN cord-010092-uftc8inx 7922 51 surveillance surveillance NN cord-010092-uftc8inx 7922 52 data datum NNS cord-010092-uftc8inx 7922 53 for for IN cord-010092-uftc8inx 7922 54 2010 2010 CD cord-010092-uftc8inx 7922 55 - - SYM cord-010092-uftc8inx 7922 56 2018 2018 CD cord-010092-uftc8inx 7922 57 ( ( -LRB- cord-010092-uftc8inx 7922 58 2018 2018 CD cord-010092-uftc8inx 7922 59 : : : cord-010092-uftc8inx 7922 60 preliminary preliminary JJ cord-010092-uftc8inx 7922 61 ) ) -RRB- cord-010092-uftc8inx 7922 62 were be VBD cord-010092-uftc8inx 7922 63 reviewed review VBN cord-010092-uftc8inx 7922 64 . . . cord-010092-uftc8inx 7923 1 Annual annual JJ cord-010092-uftc8inx 7923 2 prevalence prevalence NN cord-010092-uftc8inx 7923 3 and and CC cord-010092-uftc8inx 7923 4 incidence incidence NN cord-010092-uftc8inx 7923 5 of of IN cord-010092-uftc8inx 7923 6 HBV HBV NNP cord-010092-uftc8inx 7923 7 and and CC cord-010092-uftc8inx 7923 8 HIV HIV NNP cord-010092-uftc8inx 7923 9 infection infection NN cord-010092-uftc8inx 7923 10 were be VBD cord-010092-uftc8inx 7923 11 estimated estimate VBN cord-010092-uftc8inx 7923 12 , , , cord-010092-uftc8inx 7923 13 with with IN cord-010092-uftc8inx 7923 14 a a DT cord-010092-uftc8inx 7923 15 Poisson Poisson NNP cord-010092-uftc8inx 7923 16 regression regression NN cord-010092-uftc8inx 7923 17 models model NNS cord-010092-uftc8inx 7923 18 to to TO cord-010092-uftc8inx 7923 19 test test VB cord-010092-uftc8inx 7923 20 for for IN cord-010092-uftc8inx 7923 21 trends trend NNS cord-010092-uftc8inx 7923 22 . . . cord-010092-uftc8inx 7924 1 Incidence incidence NN cord-010092-uftc8inx 7924 2 was be VBD cord-010092-uftc8inx 7924 3 calculated calculate VBN cord-010092-uftc8inx 7924 4 from from IN cord-010092-uftc8inx 7924 5 donors donor NNS cord-010092-uftc8inx 7924 6 seroconverting seroconverte VBG cord-010092-uftc8inx 7924 7 within within IN cord-010092-uftc8inx 7924 8 12-months 12-months CD cord-010092-uftc8inx 7924 9 , , , cord-010092-uftc8inx 7924 10 and/or and/or CC cord-010092-uftc8inx 7924 11 microbiological microbiological JJ cord-010092-uftc8inx 7924 12 and and CC cord-010092-uftc8inx 7924 13 clinical clinical JJ cord-010092-uftc8inx 7924 14 evidence evidence NN cord-010092-uftc8inx 7924 15 of of IN cord-010092-uftc8inx 7924 16 recent recent JJ cord-010092-uftc8inx 7924 17 infection infection NN cord-010092-uftc8inx 7924 18 . . . cord-010092-uftc8inx 7925 1 For for IN cord-010092-uftc8inx 7925 2 donors donor NNS cord-010092-uftc8inx 7925 3 positive positive JJ cord-010092-uftc8inx 7925 4 in in IN cord-010092-uftc8inx 7925 5 2018 2018 CD cord-010092-uftc8inx 7925 6 , , , cord-010092-uftc8inx 7925 7 compliance compliance NN cord-010092-uftc8inx 7925 8 with with IN cord-010092-uftc8inx 7925 9 the the DT cord-010092-uftc8inx 7925 10 3-month 3-month CD cord-010092-uftc8inx 7925 11 deferral deferral NN cord-010092-uftc8inx 7925 12 was be VBD cord-010092-uftc8inx 7925 13 determined determine VBN cord-010092-uftc8inx 7925 14 . . . cord-010092-uftc8inx 7926 1 UK UK NNP cord-010092-uftc8inx 7926 2 hemovigilance hemovigilance NNP cord-010092-uftc8inx 7926 3 data datum NNS cord-010092-uftc8inx 7926 4 were be VBD cord-010092-uftc8inx 7926 5 scrutinised scrutinise VBN cord-010092-uftc8inx 7926 6 for for IN cord-010092-uftc8inx 7926 7 evidence evidence NN cord-010092-uftc8inx 7926 8 of of IN cord-010092-uftc8inx 7926 9 transfusion transfusion NN cord-010092-uftc8inx 7926 10 transmitted transmit VBN cord-010092-uftc8inx 7926 11 infections infection NNS cord-010092-uftc8inx 7926 12 ( ( -LRB- cord-010092-uftc8inx 7926 13 TTI TTI NNP cord-010092-uftc8inx 7926 14 ) ) -RRB- cord-010092-uftc8inx 7926 15 associated associate VBN cord-010092-uftc8inx 7926 16 with with IN cord-010092-uftc8inx 7926 17 newly newly RB cord-010092-uftc8inx 7926 18 eligible eligible JJ cord-010092-uftc8inx 7926 19 donors donor NNS cord-010092-uftc8inx 7926 20 . . . cord-010092-uftc8inx 7927 1 Results result NNS cord-010092-uftc8inx 7927 2 : : : cord-010092-uftc8inx 7928 1 From from IN cord-010092-uftc8inx 7928 2 2010 2010 CD cord-010092-uftc8inx 7928 3 to to IN cord-010092-uftc8inx 7928 4 2018 2018 CD cord-010092-uftc8inx 7928 5 among among IN cord-010092-uftc8inx 7928 6 new new JJ cord-010092-uftc8inx 7928 7 donors donor NNS cord-010092-uftc8inx 7928 8 , , , cord-010092-uftc8inx 7928 9 annual annual JJ cord-010092-uftc8inx 7928 10 HIV HIV NNP cord-010092-uftc8inx 7928 11 prevalence prevalence NN cord-010092-uftc8inx 7928 12 decreased decrease VBD cord-010092-uftc8inx 7928 13 significantly significantly RB cord-010092-uftc8inx 7928 14 by by IN cord-010092-uftc8inx 7928 15 an an DT cord-010092-uftc8inx 7928 16 average average NN cord-010092-uftc8inx 7928 17 of of IN cord-010092-uftc8inx 7928 18 11.3 11.3 CD cord-010092-uftc8inx 7928 19 % % NN cord-010092-uftc8inx 7928 20 each each DT cord-010092-uftc8inx 7928 21 year year NN cord-010092-uftc8inx 7928 22 ( ( -LRB- cord-010092-uftc8inx 7928 23 P p NN cord-010092-uftc8inx 7928 24 = = SYM cord-010092-uftc8inx 7928 25 0.02 0.02 CD cord-010092-uftc8inx 7928 26 ) ) -RRB- cord-010092-uftc8inx 7928 27 to to IN cord-010092-uftc8inx 7928 28 1.49/100,000 1.49/100,000 CD cord-010092-uftc8inx 7928 29 donations donation NNS cord-010092-uftc8inx 7928 30 in in IN cord-010092-uftc8inx 7928 31 2018 2018 CD cord-010092-uftc8inx 7928 32 ; ; : cord-010092-uftc8inx 7928 33 no no DT cord-010092-uftc8inx 7928 34 significant significant JJ cord-010092-uftc8inx 7928 35 trend trend NN cord-010092-uftc8inx 7928 36 was be VBD cord-010092-uftc8inx 7928 37 observed observe VBN cord-010092-uftc8inx 7928 38 for for IN cord-010092-uftc8inx 7928 39 HBV HBV NNP cord-010092-uftc8inx 7928 40 . . . cord-010092-uftc8inx 7929 1 Annual annual JJ cord-010092-uftc8inx 7929 2 HIV HIV NNP cord-010092-uftc8inx 7929 3 incidence incidence NN cord-010092-uftc8inx 7929 4 among among IN cord-010092-uftc8inx 7929 5 repeat repeat NN cord-010092-uftc8inx 7929 6 donors donor NNS cord-010092-uftc8inx 7929 7 also also RB cord-010092-uftc8inx 7929 8 decreased decrease VBD cord-010092-uftc8inx 7929 9 significantly significantly RB cord-010092-uftc8inx 7929 10 by by IN cord-010092-uftc8inx 7929 11 an an DT cord-010092-uftc8inx 7929 12 average average NN cord-010092-uftc8inx 7929 13 of of IN cord-010092-uftc8inx 7929 14 17.3 17.3 CD cord-010092-uftc8inx 7929 15 % % NN cord-010092-uftc8inx 7929 16 each each DT cord-010092-uftc8inx 7929 17 year year NN cord-010092-uftc8inx 7929 18 ( ( -LRB- cord-010092-uftc8inx 7929 19 P p NN cord-010092-uftc8inx 7929 20 = = SYM cord-010092-uftc8inx 7929 21 0.03 0.03 CD cord-010092-uftc8inx 7929 22 ) ) -RRB- cord-010092-uftc8inx 7929 23 to to IN cord-010092-uftc8inx 7929 24 0.23/100,000-person 0.23/100,000-person CD cord-010092-uftc8inx 7929 25 years year NNS cord-010092-uftc8inx 7929 26 ( ( -LRB- cord-010092-uftc8inx 7929 27 pyrs pyr NNS cord-010092-uftc8inx 7929 28 ) ) -RRB- cord-010092-uftc8inx 7929 29 in in IN cord-010092-uftc8inx 7929 30 2018 2018 CD cord-010092-uftc8inx 7929 31 ( ( -LRB- cord-010092-uftc8inx 7929 32 based base VBN cord-010092-uftc8inx 7929 33 on on IN cord-010092-uftc8inx 7929 34 2 2 CD cord-010092-uftc8inx 7929 35 seroconverters seroconverter NNS cord-010092-uftc8inx 7929 36 ) ) -RRB- cord-010092-uftc8inx 7929 37 . . . cord-010092-uftc8inx 7930 1 There there EX cord-010092-uftc8inx 7930 2 was be VBD cord-010092-uftc8inx 7930 3 no no DT cord-010092-uftc8inx 7930 4 significant significant JJ cord-010092-uftc8inx 7930 5 trend trend NN cord-010092-uftc8inx 7930 6 in in IN cord-010092-uftc8inx 7930 7 HBV HBV NNP cord-010092-uftc8inx 7930 8 incidence incidence NN cord-010092-uftc8inx 7930 9 over over IN cord-010092-uftc8inx 7930 10 the the DT cord-010092-uftc8inx 7930 11 study study NN cord-010092-uftc8inx 7930 12 period period NN cord-010092-uftc8inx 7930 13 , , , cord-010092-uftc8inx 7930 14 however however RB cord-010092-uftc8inx 7930 15 between between IN cord-010092-uftc8inx 7930 16 2017 2017 CD cord-010092-uftc8inx 7930 17 and and CC cord-010092-uftc8inx 7930 18 2018 2018 CD cord-010092-uftc8inx 7930 19 incidence incidence NN cord-010092-uftc8inx 7930 20 increased increase VBD cord-010092-uftc8inx 7930 21 from from IN cord-010092-uftc8inx 7930 22 0.35/100,000 0.35/100,000 CD cord-010092-uftc8inx 7930 23 pyrs pyr NNS cord-010092-uftc8inx 7930 24 to to IN cord-010092-uftc8inx 7930 25 0.84/ 0.84/ CD cord-010092-uftc8inx 7930 26 100,000 100,000 CD cord-010092-uftc8inx 7930 27 / / SYM cord-010092-uftc8inx 7930 28 pyrs pyr NNS cord-010092-uftc8inx 7930 29 ( ( -LRB- cord-010092-uftc8inx 7930 30 based base VBN cord-010092-uftc8inx 7930 31 on on IN cord-010092-uftc8inx 7930 32 3 3 CD cord-010092-uftc8inx 7930 33 and and CC cord-010092-uftc8inx 7930 34 7 7 CD cord-010092-uftc8inx 7930 35 seroconverters seroconverter NNS cord-010092-uftc8inx 7930 36 respectively respectively RB cord-010092-uftc8inx 7930 37 ) ) -RRB- cord-010092-uftc8inx 7930 38 . . . cord-010092-uftc8inx 7931 1 With with IN cord-010092-uftc8inx 7931 2 the the DT cord-010092-uftc8inx 7931 3 information information NN cord-010092-uftc8inx 7931 4 available available JJ cord-010092-uftc8inx 7931 5 to to IN cord-010092-uftc8inx 7931 6 date date NN cord-010092-uftc8inx 7931 7 , , , cord-010092-uftc8inx 7931 8 none none NN cord-010092-uftc8inx 7931 9 of of IN cord-010092-uftc8inx 7931 10 the the DT cord-010092-uftc8inx 7931 11 2018 2018 CD cord-010092-uftc8inx 7931 12 seroconverting seroconverte VBG cord-010092-uftc8inx 7931 13 donors donor NNS cord-010092-uftc8inx 7931 14 were be VBD cord-010092-uftc8inx 7931 15 non non JJ cord-010092-uftc8inx 7931 16 - - JJ cord-010092-uftc8inx 7931 17 compliant compliant JJ cord-010092-uftc8inx 7931 18 , , , cord-010092-uftc8inx 7931 19 and and CC cord-010092-uftc8inx 7931 20 there there EX cord-010092-uftc8inx 7931 21 was be VBD cord-010092-uftc8inx 7931 22 no no DT cord-010092-uftc8inx 7931 23 reported report VBN cord-010092-uftc8inx 7931 24 confirmed confirm VBN cord-010092-uftc8inx 7931 25 TTIs tti NNS cord-010092-uftc8inx 7931 26 associated associate VBN cord-010092-uftc8inx 7931 27 with with IN cord-010092-uftc8inx 7931 28 the the DT cord-010092-uftc8inx 7931 29 policy policy NN cord-010092-uftc8inx 7931 30 change change NN cord-010092-uftc8inx 7931 31 . . . cord-010092-uftc8inx 7932 1 Summary Summary NNP cord-010092-uftc8inx 7932 2 / / SYM cord-010092-uftc8inx 7932 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 7932 4 : : : cord-010092-uftc8inx 7933 1 HIV HIV NNP cord-010092-uftc8inx 7933 2 prevalence prevalence NN cord-010092-uftc8inx 7933 3 and and CC cord-010092-uftc8inx 7933 4 incidence incidence NN cord-010092-uftc8inx 7933 5 has have VBZ cord-010092-uftc8inx 7933 6 continued continue VBN cord-010092-uftc8inx 7933 7 to to TO cord-010092-uftc8inx 7933 8 decline decline VB cord-010092-uftc8inx 7933 9 . . . cord-010092-uftc8inx 7934 1 HBV HBV NNP cord-010092-uftc8inx 7934 2 incidence incidence NN cord-010092-uftc8inx 7934 3 in in IN cord-010092-uftc8inx 7934 4 repeat repeat NN cord-010092-uftc8inx 7934 5 donors donor NNS cord-010092-uftc8inx 7934 6 increased increase VBD cord-010092-uftc8inx 7934 7 in in IN cord-010092-uftc8inx 7934 8 2018 2018 CD cord-010092-uftc8inx 7934 9 although although IN cord-010092-uftc8inx 7934 10 initial initial JJ cord-010092-uftc8inx 7934 11 analysis analysis NN cord-010092-uftc8inx 7934 12 suggests suggest VBZ cord-010092-uftc8inx 7934 13 this this DT cord-010092-uftc8inx 7934 14 is be VBZ cord-010092-uftc8inx 7934 15 not not RB cord-010092-uftc8inx 7934 16 associated associate VBN cord-010092-uftc8inx 7934 17 with with IN cord-010092-uftc8inx 7934 18 the the DT cord-010092-uftc8inx 7934 19 policy policy NN cord-010092-uftc8inx 7934 20 change change NN cord-010092-uftc8inx 7934 21 . . . cord-010092-uftc8inx 7935 1 Monitoring monitoring NN cord-010092-uftc8inx 7935 2 continues continue VBZ cord-010092-uftc8inx 7935 3 , , , cord-010092-uftc8inx 7935 4 and and CC cord-010092-uftc8inx 7935 5 residual residual JJ cord-010092-uftc8inx 7935 6 risks risk NNS cord-010092-uftc8inx 7935 7 will will MD cord-010092-uftc8inx 7935 8 be be VB cord-010092-uftc8inx 7935 9 re re VBN cord-010092-uftc8inx 7935 10 - - VBN cord-010092-uftc8inx 7935 11 estimated estimate VBN cord-010092-uftc8inx 7935 12 as as IN cord-010092-uftc8inx 7935 13 data datum NNS cord-010092-uftc8inx 7935 14 post post VBP cord-010092-uftc8inx 7935 15 - - NN cord-010092-uftc8inx 7935 16 change change NN cord-010092-uftc8inx 7935 17 accumulate accumulate NN cord-010092-uftc8inx 7935 18 . . . cord-010092-uftc8inx 7936 1 These these DT cord-010092-uftc8inx 7936 2 data datum NNS cord-010092-uftc8inx 7936 3 are be VBP cord-010092-uftc8inx 7936 4 reassuring reassuring JJ cord-010092-uftc8inx 7936 5 , , , cord-010092-uftc8inx 7936 6 and and CC cord-010092-uftc8inx 7936 7 therefore therefore RB cord-010092-uftc8inx 7936 8 it -PRON- PRP cord-010092-uftc8inx 7936 9 is be VBZ cord-010092-uftc8inx 7936 10 appropriate appropriate JJ cord-010092-uftc8inx 7936 11 to to TO cord-010092-uftc8inx 7936 12 scope scope VB cord-010092-uftc8inx 7936 13 the the DT cord-010092-uftc8inx 7936 14 evidence evidence NN cord-010092-uftc8inx 7936 15 for for IN cord-010092-uftc8inx 7936 16 , , , cord-010092-uftc8inx 7936 17 and and CC cord-010092-uftc8inx 7936 18 feasibility feasibility NN cord-010092-uftc8inx 7936 19 of of IN cord-010092-uftc8inx 7936 20 , , , cord-010092-uftc8inx 7936 21 a a DT cord-010092-uftc8inx 7936 22 more more RBR cord-010092-uftc8inx 7936 23 individualised individualised JJ cord-010092-uftc8inx 7936 24 approach approach NN cord-010092-uftc8inx 7936 25 to to IN cord-010092-uftc8inx 7936 26 selection selection NN cord-010092-uftc8inx 7936 27 policy policy NN cord-010092-uftc8inx 7936 28 . . . cord-010092-uftc8inx 7937 1 A a DT cord-010092-uftc8inx 7937 2 multidisciplinary multidisciplinary JJ cord-010092-uftc8inx 7937 3 steering steering NN cord-010092-uftc8inx 7937 4 group group NN cord-010092-uftc8inx 7937 5 has have VBZ cord-010092-uftc8inx 7937 6 been be VBN cord-010092-uftc8inx 7937 7 convened convene VBN cord-010092-uftc8inx 7937 8 including include VBG cord-010092-uftc8inx 7937 9 representation representation NN cord-010092-uftc8inx 7937 10 from from IN cord-010092-uftc8inx 7937 11 patient patient NN cord-010092-uftc8inx 7937 12 and and CC cord-010092-uftc8inx 7937 13 stakeholder stakeholder NN cord-010092-uftc8inx 7937 14 groups group NNS cord-010092-uftc8inx 7937 15 . . . cord-010092-uftc8inx 7938 1 Gaps gap NNS cord-010092-uftc8inx 7938 2 in in IN cord-010092-uftc8inx 7938 3 knowledge knowledge NN cord-010092-uftc8inx 7938 4 are be VBP cord-010092-uftc8inx 7938 5 being be VBG cord-010092-uftc8inx 7938 6 defined define VBN cord-010092-uftc8inx 7938 7 , , , cord-010092-uftc8inx 7938 8 and and CC cord-010092-uftc8inx 7938 9 a a DT cord-010092-uftc8inx 7938 10 package package NN cord-010092-uftc8inx 7938 11 of of IN cord-010092-uftc8inx 7938 12 work work NN cord-010092-uftc8inx 7938 13 is be VBZ cord-010092-uftc8inx 7938 14 in in IN cord-010092-uftc8inx 7938 15 development development NN cord-010092-uftc8inx 7938 16 under under IN cord-010092-uftc8inx 7938 17 the the DT cord-010092-uftc8inx 7938 18 project project NN cord-010092-uftc8inx 7938 19 of of IN cord-010092-uftc8inx 7938 20 FAIR FAIR NNP cord-010092-uftc8inx 7939 1 ( ( -LRB- cord-010092-uftc8inx 7939 2 For for IN cord-010092-uftc8inx 7939 3 the the DT cord-010092-uftc8inx 7939 4 Assessment Assessment NNP cord-010092-uftc8inx 7939 5 of of IN cord-010092-uftc8inx 7939 6 Individualised Individualised NNP cord-010092-uftc8inx 7939 7 Risk Risk NNP cord-010092-uftc8inx 7939 8 ) ) -RRB- cord-010092-uftc8inx 7939 9 , , , cord-010092-uftc8inx 7939 10 using use VBG cord-010092-uftc8inx 7939 11 the the DT cord-010092-uftc8inx 7939 12 ABO ABO NNP cord-010092-uftc8inx 7939 13 RDF RDF NNP cord-010092-uftc8inx 7939 14 for for IN cord-010092-uftc8inx 7939 15 guidance guidance NN cord-010092-uftc8inx 7939 16 . . . cord-010092-uftc8inx 7940 1 Background background NN cord-010092-uftc8inx 7940 2 : : : cord-010092-uftc8inx 7941 1 Permanent permanent JJ cord-010092-uftc8inx 7941 2 deferral deferral NN cord-010092-uftc8inx 7941 3 of of IN cord-010092-uftc8inx 7941 4 men man NNS cord-010092-uftc8inx 7941 5 who who WP cord-010092-uftc8inx 7941 6 have have VBP cord-010092-uftc8inx 7941 7 sex sex NN cord-010092-uftc8inx 7941 8 with with IN cord-010092-uftc8inx 7941 9 men man NNS cord-010092-uftc8inx 7941 10 ( ( -LRB- cord-010092-uftc8inx 7941 11 MSM MSM NNP cord-010092-uftc8inx 7941 12 ) ) -RRB- cord-010092-uftc8inx 7941 13 , , , cord-010092-uftc8inx 7941 14 established establish VBN cord-010092-uftc8inx 7941 15 in in IN cord-010092-uftc8inx 7941 16 the the DT cord-010092-uftc8inx 7941 17 1980s 1980 NNS cord-010092-uftc8inx 7941 18 , , , cord-010092-uftc8inx 7941 19 primarily primarily RB cord-010092-uftc8inx 7941 20 to to TO cord-010092-uftc8inx 7941 21 minimise minimise VB cord-010092-uftc8inx 7941 22 the the DT cord-010092-uftc8inx 7941 23 risk risk NN cord-010092-uftc8inx 7941 24 of of IN cord-010092-uftc8inx 7941 25 HIV HIV NNP cord-010092-uftc8inx 7941 26 transfusion transfusion NN cord-010092-uftc8inx 7941 27 - - HYPH cord-010092-uftc8inx 7941 28 transmitted transmit VBN cord-010092-uftc8inx 7941 29 infections infection NNS cord-010092-uftc8inx 7941 30 is be VBZ cord-010092-uftc8inx 7941 31 increasingly increasingly RB cord-010092-uftc8inx 7941 32 challenged challenge VBN cord-010092-uftc8inx 7941 33 . . . cord-010092-uftc8inx 7942 1 Accordingly accordingly RB cord-010092-uftc8inx 7942 2 , , , cord-010092-uftc8inx 7942 3 blood blood NN cord-010092-uftc8inx 7942 4 services service NNS cord-010092-uftc8inx 7942 5 in in IN cord-010092-uftc8inx 7942 6 many many JJ cord-010092-uftc8inx 7942 7 countries country NNS cord-010092-uftc8inx 7942 8 have have VBP cord-010092-uftc8inx 7942 9 changed change VBN cord-010092-uftc8inx 7942 10 to to IN cord-010092-uftc8inx 7942 11 time time NN cord-010092-uftc8inx 7942 12 - - HYPH cord-010092-uftc8inx 7942 13 based base VBN cord-010092-uftc8inx 7942 14 deferral deferral NN cord-010092-uftc8inx 7942 15 . . . cord-010092-uftc8inx 7943 1 In in IN cord-010092-uftc8inx 7943 2 Canada Canada NNP cord-010092-uftc8inx 7943 3 , , , cord-010092-uftc8inx 7943 4 a a DT cord-010092-uftc8inx 7943 5 5-year 5-year CD cord-010092-uftc8inx 7943 6 deferral deferral NN cord-010092-uftc8inx 7943 7 was be VBD cord-010092-uftc8inx 7943 8 implemented implement VBN cord-010092-uftc8inx 7943 9 in in IN cord-010092-uftc8inx 7943 10 2013 2013 CD cord-010092-uftc8inx 7943 11 , , , cord-010092-uftc8inx 7943 12 reduced reduce VBN cord-010092-uftc8inx 7943 13 to to IN cord-010092-uftc8inx 7943 14 12-months 12-months CD cord-010092-uftc8inx 7943 15 in in IN cord-010092-uftc8inx 7943 16 2016 2016 CD cord-010092-uftc8inx 7943 17 ; ; : cord-010092-uftc8inx 7943 18 a a DT cord-010092-uftc8inx 7943 19 3-month 3-month CD cord-010092-uftc8inx 7943 20 deferral deferral NN cord-010092-uftc8inx 7943 21 is be VBZ cord-010092-uftc8inx 7943 22 now now RB cord-010092-uftc8inx 7943 23 being be VBG cord-010092-uftc8inx 7943 24 considered consider VBN cord-010092-uftc8inx 7943 25 . . . cord-010092-uftc8inx 7944 1 Aims aim VBZ cord-010092-uftc8inx 7944 2 : : : cord-010092-uftc8inx 7945 1 To to TO cord-010092-uftc8inx 7945 2 estimate estimate VB cord-010092-uftc8inx 7945 3 the the DT cord-010092-uftc8inx 7945 4 risk risk NN cord-010092-uftc8inx 7945 5 of of IN cord-010092-uftc8inx 7945 6 undetected undetected JJ cord-010092-uftc8inx 7945 7 HIV HIV NNP cord-010092-uftc8inx 7945 8 among among IN cord-010092-uftc8inx 7945 9 screened screen VBN cord-010092-uftc8inx 7945 10 blood blood NN cord-010092-uftc8inx 7945 11 donations donation NNS cord-010092-uftc8inx 7945 12 under under IN cord-010092-uftc8inx 7945 13 a a DT cord-010092-uftc8inx 7945 14 3-month 3-month CD cord-010092-uftc8inx 7945 15 deferral deferral NN cord-010092-uftc8inx 7945 16 since since IN cord-010092-uftc8inx 7945 17 last last JJ cord-010092-uftc8inx 7945 18 sex sex NN cord-010092-uftc8inx 7945 19 between between IN cord-010092-uftc8inx 7945 20 men man NNS cord-010092-uftc8inx 7945 21 . . . cord-010092-uftc8inx 7946 1 Methods method NNS cord-010092-uftc8inx 7946 2 : : : cord-010092-uftc8inx 7947 1 The the DT cord-010092-uftc8inx 7947 2 applied applied JJ cord-010092-uftc8inx 7947 3 model model NN cord-010092-uftc8inx 7947 4 combines combine VBZ cord-010092-uftc8inx 7947 5 features feature NNS cord-010092-uftc8inx 7947 6 of of IN cord-010092-uftc8inx 7947 7 previously previously RB cord-010092-uftc8inx 7947 8 published publish VBN cord-010092-uftc8inx 7947 9 English english JJ cord-010092-uftc8inx 7947 10 and and CC cord-010092-uftc8inx 7947 11 Canadian canadian JJ cord-010092-uftc8inx 7947 12 models model NNS cord-010092-uftc8inx 7947 13 to to TO cord-010092-uftc8inx 7947 14 estimate estimate VB cord-010092-uftc8inx 7947 15 HIV HIV NNP cord-010092-uftc8inx 7947 16 risk risk NN cord-010092-uftc8inx 7947 17 under under IN cord-010092-uftc8inx 7947 18 a a DT cord-010092-uftc8inx 7947 19 12-month 12-month JJ cord-010092-uftc8inx 7947 20 deferral deferral NN cord-010092-uftc8inx 7947 21 . . . cord-010092-uftc8inx 7948 1 Three three CD cord-010092-uftc8inx 7948 2 scenarios scenario NNS cord-010092-uftc8inx 7948 3 varying vary VBG cord-010092-uftc8inx 7948 4 HIV HIV NNP cord-010092-uftc8inx 7948 5 incidence incidence NN cord-010092-uftc8inx 7948 6 , , , cord-010092-uftc8inx 7948 7 prevalence prevalence NN cord-010092-uftc8inx 7948 8 and and CC cord-010092-uftc8inx 7948 9 non non JJ cord-010092-uftc8inx 7948 10 - - JJ cord-010092-uftc8inx 7948 11 compliance compliance NN cord-010092-uftc8inx 7948 12 under under IN cord-010092-uftc8inx 7948 13 a a DT cord-010092-uftc8inx 7948 14 3-month 3-month CD cord-010092-uftc8inx 7948 15 deferral deferral NN cord-010092-uftc8inx 7948 16 were be VBD cord-010092-uftc8inx 7948 17 modelled model VBN cord-010092-uftc8inx 7948 18 . . . cord-010092-uftc8inx 7949 1 Assumed assume VBN cord-010092-uftc8inx 7949 2 constants constant NNS cord-010092-uftc8inx 7949 3 were be VBD cord-010092-uftc8inx 7949 4 the the DT cord-010092-uftc8inx 7949 5 HIV HIV NNP cord-010092-uftc8inx 7949 6 nucleic nucleic JJ cord-010092-uftc8inx 7949 7 acid acid NN cord-010092-uftc8inx 7949 8 window window NN cord-010092-uftc8inx 7949 9 period period NN cord-010092-uftc8inx 7949 10 , , , cord-010092-uftc8inx 7949 11 testing test VBG cord-010092-uftc8inx 7949 12 procedure procedure NN cord-010092-uftc8inx 7949 13 error error NN cord-010092-uftc8inx 7949 14 rate rate NN cord-010092-uftc8inx 7949 15 and and CC cord-010092-uftc8inx 7949 16 assay assay NN cord-010092-uftc8inx 7949 17 sensitivity sensitivity NN cord-010092-uftc8inx 7949 18 . . . cord-010092-uftc8inx 7950 1 Model model NN cord-010092-uftc8inx 7950 2 inputs input NNS cord-010092-uftc8inx 7950 3 were be VBD cord-010092-uftc8inx 7950 4 incidence incidence NN cord-010092-uftc8inx 7950 5 under under IN cord-010092-uftc8inx 7950 6 the the DT cord-010092-uftc8inx 7950 7 current current JJ cord-010092-uftc8inx 7950 8 12-month 12-month JJ cord-010092-uftc8inx 7950 9 deferral deferral NN cord-010092-uftc8inx 7950 10 , , , cord-010092-uftc8inx 7950 11 calculated calculate VBN cord-010092-uftc8inx 7950 12 as as IN cord-010092-uftc8inx 7950 13 HIV HIV NNP cord-010092-uftc8inx 7950 14 positive positive JJ cord-010092-uftc8inx 7950 15 donors donor NNS cord-010092-uftc8inx 7950 16 with with IN cord-010092-uftc8inx 7950 17 a a DT cord-010092-uftc8inx 7950 18 previous previous JJ cord-010092-uftc8inx 7950 19 negative negative NN cord-010092-uftc8inx 7950 20 within within IN cord-010092-uftc8inx 7950 21 12 12 CD cord-010092-uftc8inx 7950 22 months month NNS cord-010092-uftc8inx 7950 23 divided divide VBN cord-010092-uftc8inx 7950 24 by by IN cord-010092-uftc8inx 7950 25 number number NN cord-010092-uftc8inx 7950 26 of of IN cord-010092-uftc8inx 7950 27 person person NN cord-010092-uftc8inx 7950 28 years year NNS cord-010092-uftc8inx 7950 29 , , , cord-010092-uftc8inx 7950 30 numbers number NNS cord-010092-uftc8inx 7950 31 of of IN cord-010092-uftc8inx 7950 32 HIV HIV NNP cord-010092-uftc8inx 7950 33 positive positive JJ cord-010092-uftc8inx 7950 34 donations donation NNS cord-010092-uftc8inx 7950 35 , , , cord-010092-uftc8inx 7950 36 HIV HIV NNP cord-010092-uftc8inx 7950 37 positive positive JJ cord-010092-uftc8inx 7950 38 MSM MSM NNP cord-010092-uftc8inx 7950 39 , , , cord-010092-uftc8inx 7950 40 HIV HIV NNP cord-010092-uftc8inx 7950 41 MSM MSM NNP cord-010092-uftc8inx 7950 42 incident incident NN cord-010092-uftc8inx 7950 43 cases case NNS cord-010092-uftc8inx 7950 44 and and CC cord-010092-uftc8inx 7950 45 newly newly RB cord-010092-uftc8inx 7950 46 eligible eligible JJ cord-010092-uftc8inx 7950 47 MSM MSM NNP cord-010092-uftc8inx 7950 48 donors donor NNS cord-010092-uftc8inx 7950 49 ( ( -LRB- cord-010092-uftc8inx 7950 50 from from IN cord-010092-uftc8inx 7950 51 donor donor NN cord-010092-uftc8inx 7950 52 surveillance surveillance NN cord-010092-uftc8inx 7950 53 and and CC cord-010092-uftc8inx 7950 54 compliance compliance NN cord-010092-uftc8inx 7950 55 surveys survey NNS cord-010092-uftc8inx 7950 56 ) ) -RRB- cord-010092-uftc8inx 7950 57 . . . cord-010092-uftc8inx 7951 1 The the DT cord-010092-uftc8inx 7951 2 risk risk NN cord-010092-uftc8inx 7951 3 with with IN cord-010092-uftc8inx 7951 4 a a DT cord-010092-uftc8inx 7951 5 3-month 3-month CD cord-010092-uftc8inx 7951 6 deferral deferral NN cord-010092-uftc8inx 7951 7 was be VBD cord-010092-uftc8inx 7951 8 estimated estimate VBN cord-010092-uftc8inx 7951 9 for for IN cord-010092-uftc8inx 7951 10 three three CD cord-010092-uftc8inx 7951 11 scenarios scenario NNS cord-010092-uftc8inx 7951 12 , , , cord-010092-uftc8inx 7951 13 one one CD cord-010092-uftc8inx 7951 14 determined determine VBD cord-010092-uftc8inx 7951 15 " " `` cord-010092-uftc8inx 7951 16 most most RBS cord-010092-uftc8inx 7951 17 likely likely JJ cord-010092-uftc8inx 7951 18 " " '' cord-010092-uftc8inx 7951 19 , , . cord-010092-uftc8inx 7952 1 where where WRB cord-010092-uftc8inx 7952 2 MSM MSM NNP cord-010092-uftc8inx 7952 3 donor donor NN cord-010092-uftc8inx 7952 4 non non NN cord-010092-uftc8inx 7952 5 - - NN cord-010092-uftc8inx 7952 6 compliance compliance NN cord-010092-uftc8inx 7952 7 , , , cord-010092-uftc8inx 7952 8 HIV HIV NNP cord-010092-uftc8inx 7952 9 incidence incidence NN cord-010092-uftc8inx 7952 10 and and CC cord-010092-uftc8inx 7952 11 HIV HIV NNP cord-010092-uftc8inx 7952 12 positive positive JJ cord-010092-uftc8inx 7952 13 donations donation NNS cord-010092-uftc8inx 7952 14 do do VBP cord-010092-uftc8inx 7952 15 not not RB cord-010092-uftc8inx 7952 16 change change VB cord-010092-uftc8inx 7952 17 and and CC cord-010092-uftc8inx 7952 18 MSM MSM NNP cord-010092-uftc8inx 7952 19 newly newly RB cord-010092-uftc8inx 7952 20 eligible eligible JJ cord-010092-uftc8inx 7952 21 to to TO cord-010092-uftc8inx 7952 22 donate donate VB cord-010092-uftc8inx 7952 23 are be VBP cord-010092-uftc8inx 7952 24 estimated estimate VBN cord-010092-uftc8inx 7952 25 from from IN cord-010092-uftc8inx 7952 26 compliance compliance NN cord-010092-uftc8inx 7952 27 surveys survey NNS cord-010092-uftc8inx 7952 28 . . . cord-010092-uftc8inx 7953 1 This this DT cord-010092-uftc8inx 7953 2 scenario scenario NN cord-010092-uftc8inx 7953 3 is be VBZ cord-010092-uftc8inx 7953 4 based base VBN cord-010092-uftc8inx 7953 5 on on IN cord-010092-uftc8inx 7953 6 data datum NNS cord-010092-uftc8inx 7953 7 from from IN cord-010092-uftc8inx 7953 8 two two CD cord-010092-uftc8inx 7953 9 sequential sequential JJ cord-010092-uftc8inx 7953 10 policy policy NN cord-010092-uftc8inx 7953 11 changes change NNS cord-010092-uftc8inx 7953 12 in in IN cord-010092-uftc8inx 7953 13 Canada Canada NNP cord-010092-uftc8inx 7953 14 . . . cord-010092-uftc8inx 7954 1 An an DT cord-010092-uftc8inx 7954 2 " " `` cord-010092-uftc8inx 7954 3 optimistic optimistic JJ cord-010092-uftc8inx 7954 4 " " '' cord-010092-uftc8inx 7954 5 scenario scenario NN cord-010092-uftc8inx 7954 6 where where WRB cord-010092-uftc8inx 7954 7 non non JJ cord-010092-uftc8inx 7954 8 - - JJ cord-010092-uftc8inx 7954 9 compliance compliance JJ cord-010092-uftc8inx 7954 10 halves half NNS cord-010092-uftc8inx 7954 11 and and CC cord-010092-uftc8inx 7954 12 a a DT cord-010092-uftc8inx 7954 13 " " `` cord-010092-uftc8inx 7954 14 pessimistic pessimistic JJ cord-010092-uftc8inx 7954 15 " " '' cord-010092-uftc8inx 7954 16 scenario scenario NN cord-010092-uftc8inx 7954 17 where where WRB cord-010092-uftc8inx 7954 18 MSM MSM NNP cord-010092-uftc8inx 7954 19 HIV HIV NNP cord-010092-uftc8inx 7954 20 incidence incidence NN cord-010092-uftc8inx 7954 21 , , , cord-010092-uftc8inx 7954 22 HIV HIV NNP cord-010092-uftc8inx 7954 23 positive positive JJ cord-010092-uftc8inx 7954 24 donations donation NNS cord-010092-uftc8inx 7954 25 , , , cord-010092-uftc8inx 7954 26 non non JJ cord-010092-uftc8inx 7954 27 - - JJ cord-010092-uftc8inx 7954 28 compliance compliance JJ cord-010092-uftc8inx 7954 29 and and CC cord-010092-uftc8inx 7954 30 new new JJ cord-010092-uftc8inx 7954 31 MSM MSM NNP cord-010092-uftc8inx 7954 32 donors donor NNS cord-010092-uftc8inx 7954 33 double double JJ cord-010092-uftc8inx 7954 34 were be VBD cord-010092-uftc8inx 7954 35 also also RB cord-010092-uftc8inx 7954 36 used use VBN cord-010092-uftc8inx 7954 37 . . . cord-010092-uftc8inx 7955 1 The the DT cord-010092-uftc8inx 7955 2 median median JJ cord-010092-uftc8inx 7955 3 HIV HIV NNP cord-010092-uftc8inx 7955 4 residual residual JJ cord-010092-uftc8inx 7955 5 risk risk NN cord-010092-uftc8inx 7955 6 was be VBD cord-010092-uftc8inx 7955 7 used use VBN cord-010092-uftc8inx 7955 8 as as IN cord-010092-uftc8inx 7955 9 the the DT cord-010092-uftc8inx 7955 10 final final JJ cord-010092-uftc8inx 7955 11 estimate estimate NN cord-010092-uftc8inx 7955 12 . . . cord-010092-uftc8inx 7956 1 The the DT cord-010092-uftc8inx 7956 2 uncertainty uncertainty NN cord-010092-uftc8inx 7956 3 in in IN cord-010092-uftc8inx 7956 4 this this DT cord-010092-uftc8inx 7956 5 estimate estimate NN cord-010092-uftc8inx 7956 6 was be VBD cord-010092-uftc8inx 7956 7 assessed assess VBN cord-010092-uftc8inx 7956 8 with with IN cord-010092-uftc8inx 7956 9 the the DT cord-010092-uftc8inx 7956 10 2.5th 2.5th CD cord-010092-uftc8inx 7956 11 and and CC cord-010092-uftc8inx 7956 12 97.5th 97.5th CD cord-010092-uftc8inx 7956 13 percentiles percentile NNS cord-010092-uftc8inx 7956 14 over over IN cord-010092-uftc8inx 7956 15 the the DT cord-010092-uftc8inx 7956 16 simulation simulation NN cord-010092-uftc8inx 7956 17 ( ( -LRB- cord-010092-uftc8inx 7956 18 95 95 CD cord-010092-uftc8inx 7956 19 % % NN cord-010092-uftc8inx 7956 20 CI CI NNP cord-010092-uftc8inx 7956 21 ) ) -RRB- cord-010092-uftc8inx 7956 22 . . . cord-010092-uftc8inx 7957 1 Results result NNS cord-010092-uftc8inx 7957 2 : : : cord-010092-uftc8inx 7958 1 Incidence incidence NN cord-010092-uftc8inx 7958 2 , , , cord-010092-uftc8inx 7958 3 per per IN cord-010092-uftc8inx 7958 4 100,000 100,000 CD cord-010092-uftc8inx 7958 5 donations donation NNS cord-010092-uftc8inx 7958 6 , , , cord-010092-uftc8inx 7958 7 was be VBD cord-010092-uftc8inx 7958 8 estimated estimate VBN cord-010092-uftc8inx 7958 9 to to TO cord-010092-uftc8inx 7958 10 be be VB cord-010092-uftc8inx 7958 11 0.15 0.15 CD cord-010092-uftc8inx 7958 12 , , , cord-010092-uftc8inx 7958 13 0.13 0.13 CD cord-010092-uftc8inx 7958 14 and and CC cord-010092-uftc8inx 7958 15 0.27 0.27 CD cord-010092-uftc8inx 7958 16 for for IN cord-010092-uftc8inx 7958 17 the the DT cord-010092-uftc8inx 7958 18 " " `` cord-010092-uftc8inx 7958 19 most most RBS cord-010092-uftc8inx 7958 20 likely likely JJ cord-010092-uftc8inx 7958 21 " " '' cord-010092-uftc8inx 7958 22 " " `` cord-010092-uftc8inx 7958 23 optimistic optimistic JJ cord-010092-uftc8inx 7958 24 " " '' cord-010092-uftc8inx 7958 25 and and CC cord-010092-uftc8inx 7958 26 " " `` cord-010092-uftc8inx 7958 27 pessimistic pessimistic JJ cord-010092-uftc8inx 7958 28 " " '' cord-010092-uftc8inx 7958 29 scenarios scenario NNS cord-010092-uftc8inx 7958 30 , , , cord-010092-uftc8inx 7958 31 respectively respectively RB cord-010092-uftc8inx 7958 32 . . . cord-010092-uftc8inx 7959 1 For for IN cord-010092-uftc8inx 7959 2 the the DT cord-010092-uftc8inx 7959 3 3month 3month JJ cord-010092-uftc8inx 7959 4 deferral deferral NN cord-010092-uftc8inx 7959 5 " " `` cord-010092-uftc8inx 7959 6 most most RBS cord-010092-uftc8inx 7959 7 likely likely JJ cord-010092-uftc8inx 7959 8 " " '' cord-010092-uftc8inx 7959 9 scenario scenario NN cord-010092-uftc8inx 7959 10 , , , cord-010092-uftc8inx 7959 11 HIV HIV NNP cord-010092-uftc8inx 7959 12 residual residual JJ cord-010092-uftc8inx 7959 13 risk risk NN cord-010092-uftc8inx 7959 14 was be VBD cord-010092-uftc8inx 7959 15 predicted predict VBN cord-010092-uftc8inx 7959 16 to to TO cord-010092-uftc8inx 7959 17 be be VB cord-010092-uftc8inx 7959 18 1 1 CD cord-010092-uftc8inx 7959 19 in in IN cord-010092-uftc8inx 7959 20 32.6 32.6 CD cord-010092-uftc8inx 7959 21 million million CD cord-010092-uftc8inx 7959 22 donations donation NNS cord-010092-uftc8inx 7959 23 ( ( -LRB- cord-010092-uftc8inx 7959 24 95 95 CD cord-010092-uftc8inx 7959 25 % % NN cord-010092-uftc8inx 7959 26 CI ci NN cord-010092-uftc8inx 7959 27 : : : cord-010092-uftc8inx 7959 28 1 1 CD cord-010092-uftc8inx 7959 29 in in IN cord-010092-uftc8inx 7959 30 217,692 217,692 CD cord-010092-uftc8inx 7959 31 million million CD cord-010092-uftc8inx 7959 32 to to IN cord-010092-uftc8inx 7959 33 1 1 CD cord-010092-uftc8inx 7959 34 in in IN cord-010092-uftc8inx 7959 35 8.3 8.3 CD cord-010092-uftc8inx 7959 36 million million CD cord-010092-uftc8inx 7959 37 ) ) -RRB- cord-010092-uftc8inx 7959 38 . . . cord-010092-uftc8inx 7960 1 For for IN cord-010092-uftc8inx 7960 2 the the DT cord-010092-uftc8inx 7960 3 " " `` cord-010092-uftc8inx 7960 4 optimistic optimistic JJ cord-010092-uftc8inx 7960 5 " " '' cord-010092-uftc8inx 7960 6 scenario scenario NN cord-010092-uftc8inx 7960 7 , , , cord-010092-uftc8inx 7960 8 HIV HIV NNP cord-010092-uftc8inx 7960 9 residual residual JJ cord-010092-uftc8inx 7960 10 risk risk NN cord-010092-uftc8inx 7960 11 was be VBD cord-010092-uftc8inx 7960 12 estimated estimate VBN cord-010092-uftc8inx 7960 13 to to TO cord-010092-uftc8inx 7960 14 be be VB cord-010092-uftc8inx 7960 15 1 1 CD cord-010092-uftc8inx 7960 16 in in IN cord-010092-uftc8inx 7960 17 34.3 34.3 CD cord-010092-uftc8inx 7960 18 million million CD cord-010092-uftc8inx 7960 19 donations donation NNS cord-010092-uftc8inx 7960 20 ( ( -LRB- cord-010092-uftc8inx 7960 21 95 95 CD cord-010092-uftc8inx 7960 22 % % NN cord-010092-uftc8inx 7960 23 CI ci NN cord-010092-uftc8inx 7960 24 : : : cord-010092-uftc8inx 7960 25 1 1 CD cord-010092-uftc8inx 7960 26 in in IN cord-010092-uftc8inx 7960 27 257,692 257,692 CD cord-010092-uftc8inx 7960 28 million million CD cord-010092-uftc8inx 7960 29 to to IN cord-010092-uftc8inx 7960 30 1 1 CD cord-010092-uftc8inx 7960 31 in in IN cord-010092-uftc8inx 7960 32 9.1 9.1 CD cord-010092-uftc8inx 7960 33 million million CD cord-010092-uftc8inx 7960 34 ) ) -RRB- cord-010092-uftc8inx 7960 35 . . . cord-010092-uftc8inx 7961 1 Finally finally RB cord-010092-uftc8inx 7961 2 , , , cord-010092-uftc8inx 7961 3 for for IN cord-010092-uftc8inx 7961 4 the the DT cord-010092-uftc8inx 7961 5 " " `` cord-010092-uftc8inx 7961 6 pessimistic pessimistic JJ cord-010092-uftc8inx 7961 7 " " '' cord-010092-uftc8inx 7961 8 scenario scenario NN cord-010092-uftc8inx 7961 9 , , , cord-010092-uftc8inx 7961 10 HIV HIV NNP cord-010092-uftc8inx 7961 11 residual residual JJ cord-010092-uftc8inx 7961 12 risk risk NN cord-010092-uftc8inx 7961 13 was be VBD cord-010092-uftc8inx 7961 14 estimated estimate VBN cord-010092-uftc8inx 7961 15 to to TO cord-010092-uftc8inx 7961 16 be be VB cord-010092-uftc8inx 7961 17 1 1 CD cord-010092-uftc8inx 7961 18 in in IN cord-010092-uftc8inx 7961 19 16.0 16.0 CD cord-010092-uftc8inx 7961 20 million million CD cord-010092-uftc8inx 7961 21 donations donation NNS cord-010092-uftc8inx 7961 22 ( ( -LRB- cord-010092-uftc8inx 7961 23 95 95 CD cord-010092-uftc8inx 7961 24 % % NN cord-010092-uftc8inx 7961 25 CI ci NN cord-010092-uftc8inx 7961 26 : : : cord-010092-uftc8inx 7961 27 1 1 CD cord-010092-uftc8inx 7961 28 in in IN cord-010092-uftc8inx 7961 29 34,091 34,091 CD cord-010092-uftc8inx 7961 30 million million CD cord-010092-uftc8inx 7961 31 to to IN cord-010092-uftc8inx 7961 32 1 1 CD cord-010092-uftc8inx 7961 33 in in IN cord-010092-uftc8inx 7961 34 5.7 5.7 CD cord-010092-uftc8inx 7961 35 million million CD cord-010092-uftc8inx 7961 36 ) ) -RRB- cord-010092-uftc8inx 7961 37 . . . cord-010092-uftc8inx 7962 1 With with IN cord-010092-uftc8inx 7962 2 these these DT cord-010092-uftc8inx 7962 3 residual residual JJ cord-010092-uftc8inx 7962 4 risk risk NN cord-010092-uftc8inx 7962 5 estimates estimate NNS cord-010092-uftc8inx 7962 6 , , , cord-010092-uftc8inx 7962 7 based base VBN cord-010092-uftc8inx 7962 8 on on IN cord-010092-uftc8inx 7962 9 the the DT cord-010092-uftc8inx 7962 10 number number NN cord-010092-uftc8inx 7962 11 of of IN cord-010092-uftc8inx 7962 12 donations donation NNS cord-010092-uftc8inx 7962 13 in in IN cord-010092-uftc8inx 7962 14 Canada Canada NNP cord-010092-uftc8inx 7962 15 , , , cord-010092-uftc8inx 7962 16 one one CD cord-010092-uftc8inx 7962 17 HIV HIV NNP cord-010092-uftc8inx 7962 18 infectious infectious JJ cord-010092-uftc8inx 7962 19 donation donation NN cord-010092-uftc8inx 7962 20 would would MD cord-010092-uftc8inx 7962 21 be be VB cord-010092-uftc8inx 7962 22 in in IN cord-010092-uftc8inx 7962 23 inventory inventory NN cord-010092-uftc8inx 7962 24 every every DT cord-010092-uftc8inx 7962 25 30 30 CD cord-010092-uftc8inx 7962 26 years year NNS cord-010092-uftc8inx 7962 27 for for IN cord-010092-uftc8inx 7962 28 the the DT cord-010092-uftc8inx 7962 29 " " `` cord-010092-uftc8inx 7962 30 most most RBS cord-010092-uftc8inx 7962 31 likely likely JJ cord-010092-uftc8inx 7962 32 " " '' cord-010092-uftc8inx 7962 33 scenario scenario NN cord-010092-uftc8inx 7962 34 , , , cord-010092-uftc8inx 7962 35 every every DT cord-010092-uftc8inx 7962 36 32 32 CD cord-010092-uftc8inx 7962 37 years year NNS cord-010092-uftc8inx 7962 38 for for IN cord-010092-uftc8inx 7962 39 the the DT cord-010092-uftc8inx 7962 40 " " `` cord-010092-uftc8inx 7962 41 optimistic optimistic JJ cord-010092-uftc8inx 7962 42 " " '' cord-010092-uftc8inx 7962 43 scenario scenario NN cord-010092-uftc8inx 7962 44 and and CC cord-010092-uftc8inx 7962 45 every every DT cord-010092-uftc8inx 7962 46 15 15 CD cord-010092-uftc8inx 7962 47 years year NNS cord-010092-uftc8inx 7962 48 for for IN cord-010092-uftc8inx 7962 49 the the DT cord-010092-uftc8inx 7962 50 " " `` cord-010092-uftc8inx 7962 51 pessimistic pessimistic JJ cord-010092-uftc8inx 7962 52 " " '' cord-010092-uftc8inx 7962 53 scenario scenario NN cord-010092-uftc8inx 7962 54 . . . cord-010092-uftc8inx 7963 1 Summary Summary NNP cord-010092-uftc8inx 7963 2 / / SYM cord-010092-uftc8inx 7963 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 7963 4 : : : cord-010092-uftc8inx 7964 1 The the DT cord-010092-uftc8inx 7964 2 risks risk NNS cord-010092-uftc8inx 7964 3 of of IN cord-010092-uftc8inx 7964 4 HIV HIV NNP cord-010092-uftc8inx 7964 5 entering enter VBG cord-010092-uftc8inx 7964 6 the the DT cord-010092-uftc8inx 7964 7 blood blood NN cord-010092-uftc8inx 7964 8 supply supply NN cord-010092-uftc8inx 7964 9 in in IN cord-010092-uftc8inx 7964 10 Canada Canada NNP cord-010092-uftc8inx 7964 11 for for IN cord-010092-uftc8inx 7964 12 a a DT cord-010092-uftc8inx 7964 13 3-month 3-month CD cord-010092-uftc8inx 7964 14 MSM MSM NNP cord-010092-uftc8inx 7964 15 deferral deferral NN cord-010092-uftc8inx 7964 16 are be VBP cord-010092-uftc8inx 7964 17 predicted predict VBN cord-010092-uftc8inx 7964 18 to to TO cord-010092-uftc8inx 7964 19 be be VB cord-010092-uftc8inx 7964 20 very very RB cord-010092-uftc8inx 7964 21 low low JJ cord-010092-uftc8inx 7964 22 for for IN cord-010092-uftc8inx 7964 23 all all DT cord-010092-uftc8inx 7964 24 modelled model VBN cord-010092-uftc8inx 7964 25 scenarios scenario NNS cord-010092-uftc8inx 7964 26 , , , cord-010092-uftc8inx 7964 27 including include VBG cord-010092-uftc8inx 7964 28 a a DT cord-010092-uftc8inx 7964 29 " " `` cord-010092-uftc8inx 7964 30 pessimistic pessimistic JJ cord-010092-uftc8inx 7964 31 " " '' cord-010092-uftc8inx 7964 32 doubling doubling NN cord-010092-uftc8inx 7964 33 of of IN cord-010092-uftc8inx 7964 34 HIV HIV NNP cord-010092-uftc8inx 7964 35 incidence incidence NN cord-010092-uftc8inx 7964 36 post post NN cord-010092-uftc8inx 7964 37 change change NN cord-010092-uftc8inx 7964 38 . . . cord-010092-uftc8inx 7965 1 Background background NN cord-010092-uftc8inx 7965 2 : : : cord-010092-uftc8inx 7965 3 Safety safety NN cord-010092-uftc8inx 7965 4 of of IN cord-010092-uftc8inx 7965 5 blood blood NN cord-010092-uftc8inx 7965 6 and and CC cord-010092-uftc8inx 7965 7 blood blood NN cord-010092-uftc8inx 7965 8 products product NNS cord-010092-uftc8inx 7965 9 is be VBZ cord-010092-uftc8inx 7965 10 a a DT cord-010092-uftc8inx 7965 11 major major JJ cord-010092-uftc8inx 7965 12 concern concern NN cord-010092-uftc8inx 7965 13 in in IN cord-010092-uftc8inx 7965 14 Pakistan Pakistan NNP cord-010092-uftc8inx 7965 15 . . . cord-010092-uftc8inx 7966 1 The the DT cord-010092-uftc8inx 7966 2 prevalence prevalence NN cord-010092-uftc8inx 7966 3 of of IN cord-010092-uftc8inx 7966 4 transfusion transfusion NN cord-010092-uftc8inx 7966 5 transmitted transmit VBN cord-010092-uftc8inx 7966 6 infections infection NNS cord-010092-uftc8inx 7966 7 among among IN cord-010092-uftc8inx 7966 8 multi multi JJ cord-010092-uftc8inx 7966 9 - - JJ cord-010092-uftc8inx 7966 10 transfused transfused JJ cord-010092-uftc8inx 7966 11 thalassaemia thalassaemia NN cord-010092-uftc8inx 7966 12 patients patient NNS cord-010092-uftc8inx 7966 13 is be VBZ cord-010092-uftc8inx 7966 14 high high JJ cord-010092-uftc8inx 7966 15 ( ( -LRB- cord-010092-uftc8inx 7966 16 above above IN cord-010092-uftc8inx 7966 17 25 25 CD cord-010092-uftc8inx 7966 18 % % NN cord-010092-uftc8inx 7966 19 ) ) -RRB- cord-010092-uftc8inx 7966 20 . . . cord-010092-uftc8inx 7967 1 The the DT cord-010092-uftc8inx 7967 2 HIV HIV NNP cord-010092-uftc8inx 7967 3 epidemic epidemic NN cord-010092-uftc8inx 7967 4 in in IN cord-010092-uftc8inx 7967 5 Pakistan Pakistan NNP cord-010092-uftc8inx 7967 6 is be VBZ cord-010092-uftc8inx 7967 7 following follow VBG cord-010092-uftc8inx 7967 8 the the DT cord-010092-uftc8inx 7967 9 Asian asian JJ cord-010092-uftc8inx 7967 10 epidemic epidemic NN cord-010092-uftc8inx 7967 11 model model NN cord-010092-uftc8inx 7967 12 where where WRB cord-010092-uftc8inx 7967 13 after after IN cord-010092-uftc8inx 7967 14 establishment establishment NN cord-010092-uftc8inx 7967 15 among among IN cord-010092-uftc8inx 7967 16 the the DT cord-010092-uftc8inx 7967 17 high high JJ cord-010092-uftc8inx 7967 18 risk risk NN cord-010092-uftc8inx 7967 19 groups group NNS cord-010092-uftc8inx 7967 20 , , , cord-010092-uftc8inx 7967 21 its -PRON- PRP$ cord-010092-uftc8inx 7967 22 transmission transmission NN cord-010092-uftc8inx 7967 23 to to IN cord-010092-uftc8inx 7967 24 general general JJ cord-010092-uftc8inx 7967 25 public public NN cord-010092-uftc8inx 7967 26 is be VBZ cord-010092-uftc8inx 7967 27 rapid rapid JJ cord-010092-uftc8inx 7967 28 . . . cord-010092-uftc8inx 7968 1 Fear fear NN cord-010092-uftc8inx 7968 2 , , , cord-010092-uftc8inx 7968 3 stigma stigma NN cord-010092-uftc8inx 7968 4 and and CC cord-010092-uftc8inx 7968 5 ignorance ignorance NN cord-010092-uftc8inx 7968 6 have have VBP cord-010092-uftc8inx 7968 7 contributed contribute VBN cord-010092-uftc8inx 7968 8 heavily heavily RB cord-010092-uftc8inx 7968 9 to to IN cord-010092-uftc8inx 7968 10 HIV HIV NNP cord-010092-uftc8inx 7968 11 transmission transmission NN cord-010092-uftc8inx 7968 12 in in IN cord-010092-uftc8inx 7968 13 Pakistan Pakistan NNP cord-010092-uftc8inx 7968 14 . . . cord-010092-uftc8inx 7969 1 The the DT cord-010092-uftc8inx 7969 2 HIV HIV NNP cord-010092-uftc8inx 7969 3 detection detection NN cord-010092-uftc8inx 7969 4 among among IN cord-010092-uftc8inx 7969 5 blood blood NN cord-010092-uftc8inx 7969 6 donors donor NNS cord-010092-uftc8inx 7969 7 is be VBZ cord-010092-uftc8inx 7969 8 on on IN cord-010092-uftc8inx 7969 9 the the DT cord-010092-uftc8inx 7969 10 rise rise NN cord-010092-uftc8inx 7969 11 and and CC cord-010092-uftc8inx 7969 12 reports report NNS cord-010092-uftc8inx 7969 13 occur occur VBP cord-010092-uftc8inx 7969 14 in in IN cord-010092-uftc8inx 7969 15 media medium NNS cord-010092-uftc8inx 7969 16 repeatedly repeatedly RB cord-010092-uftc8inx 7969 17 . . . cord-010092-uftc8inx 7970 1 Aims aim VBZ cord-010092-uftc8inx 7970 2 : : : cord-010092-uftc8inx 7970 3 To to TO cord-010092-uftc8inx 7970 4 investigate investigate VB cord-010092-uftc8inx 7970 5 the the DT cord-010092-uftc8inx 7970 6 possible possible JJ cord-010092-uftc8inx 7970 7 transmission transmission NN cord-010092-uftc8inx 7970 8 of of IN cord-010092-uftc8inx 7970 9 HIV HIV NNP cord-010092-uftc8inx 7970 10 through through IN cord-010092-uftc8inx 7970 11 blood blood NN cord-010092-uftc8inx 7970 12 transfusion transfusion NN cord-010092-uftc8inx 7970 13 in in IN cord-010092-uftc8inx 7970 14 Punjab Punjab NNP cord-010092-uftc8inx 7970 15 , , , cord-010092-uftc8inx 7970 16 Pakistan Pakistan NNP cord-010092-uftc8inx 7970 17 and and CC cord-010092-uftc8inx 7970 18 to to TO cord-010092-uftc8inx 7970 19 highlight highlight VB cord-010092-uftc8inx 7970 20 the the DT cord-010092-uftc8inx 7970 21 steps step NNS cord-010092-uftc8inx 7970 22 being be VBG cord-010092-uftc8inx 7970 23 taken take VBN cord-010092-uftc8inx 7970 24 to to TO cord-010092-uftc8inx 7970 25 reduce reduce VB cord-010092-uftc8inx 7970 26 further further JJ cord-010092-uftc8inx 7970 27 transmission transmission NN cord-010092-uftc8inx 7970 28 of of IN cord-010092-uftc8inx 7970 29 infections infection NNS cord-010092-uftc8inx 7970 30 Methods method NNS cord-010092-uftc8inx 7970 31 : : : cord-010092-uftc8inx 7971 1 In in IN cord-010092-uftc8inx 7971 2 September September NNP cord-010092-uftc8inx 7971 3 2018 2018 CD cord-010092-uftc8inx 7971 4 , , , cord-010092-uftc8inx 7971 5 a a DT cord-010092-uftc8inx 7971 6 report report NN cord-010092-uftc8inx 7971 7 of of IN cord-010092-uftc8inx 7971 8 HIV HIV NNP cord-010092-uftc8inx 7971 9 transmission transmission NN cord-010092-uftc8inx 7971 10 through through IN cord-010092-uftc8inx 7971 11 blood blood NN cord-010092-uftc8inx 7971 12 transfusion transfusion NN cord-010092-uftc8inx 7971 13 was be VBD cord-010092-uftc8inx 7971 14 reported report VBN cord-010092-uftc8inx 7971 15 in in IN cord-010092-uftc8inx 7971 16 the the DT cord-010092-uftc8inx 7971 17 media medium NNS cord-010092-uftc8inx 7971 18 where where WRB cord-010092-uftc8inx 7971 19 a a DT cord-010092-uftc8inx 7971 20 mother mother NN cord-010092-uftc8inx 7971 21 and and CC cord-010092-uftc8inx 7971 22 her -PRON- PRP$ cord-010092-uftc8inx 7971 23 newborn newborn NN cord-010092-uftc8inx 7971 24 acquired acquire VBD cord-010092-uftc8inx 7971 25 HIV HIV NNP cord-010092-uftc8inx 7971 26 after after IN cord-010092-uftc8inx 7971 27 blood blood NN cord-010092-uftc8inx 7971 28 transfusion transfusion NN cord-010092-uftc8inx 7971 29 from from IN cord-010092-uftc8inx 7971 30 a a DT cord-010092-uftc8inx 7971 31 HIV HIV NNP cord-010092-uftc8inx 7971 32 positive positive JJ cord-010092-uftc8inx 7971 33 donor donor NN cord-010092-uftc8inx 7971 34 ( ( -LRB- cord-010092-uftc8inx 7971 35 confirmed confirm VBN cord-010092-uftc8inx 7971 36 later later RB cord-010092-uftc8inx 7971 37 ) ) -RRB- cord-010092-uftc8inx 7971 38 . . . cord-010092-uftc8inx 7972 1 The the DT cord-010092-uftc8inx 7972 2 case case NN cord-010092-uftc8inx 7972 3 was be VBD cord-010092-uftc8inx 7972 4 referred refer VBN cord-010092-uftc8inx 7972 5 to to IN cord-010092-uftc8inx 7972 6 and and CC cord-010092-uftc8inx 7972 7 investigated investigate VBN cord-010092-uftc8inx 7972 8 by by IN cord-010092-uftc8inx 7972 9 the the DT cord-010092-uftc8inx 7972 10 Punjab Punjab NNP cord-010092-uftc8inx 7972 11 Blood Blood NNP cord-010092-uftc8inx 7972 12 Transfusion Transfusion NNP cord-010092-uftc8inx 7972 13 Authority Authority NNP cord-010092-uftc8inx 7972 14 ( ( -LRB- cord-010092-uftc8inx 7972 15 PBTA PBTA NNP cord-010092-uftc8inx 7972 16 ) ) -RRB- cord-010092-uftc8inx 7972 17 . . . cord-010092-uftc8inx 7973 1 The the DT cord-010092-uftc8inx 7973 2 PBTA PBTA NNP cord-010092-uftc8inx 7973 3 team team NN cord-010092-uftc8inx 7973 4 took take VBD cord-010092-uftc8inx 7973 5 blood blood NN cord-010092-uftc8inx 7973 6 samples sample NNS cord-010092-uftc8inx 7973 7 of of IN cord-010092-uftc8inx 7973 8 both both DT cord-010092-uftc8inx 7973 9 recipients recipient NNS cord-010092-uftc8inx 7973 10 ( ( -LRB- cord-010092-uftc8inx 7973 11 mother mother NN cord-010092-uftc8inx 7973 12 and and CC cord-010092-uftc8inx 7973 13 her -PRON- PRP$ cord-010092-uftc8inx 7973 14 newborn newborn JJ cord-010092-uftc8inx 7973 15 ) ) -RRB- cord-010092-uftc8inx 7973 16 and and CC cord-010092-uftc8inx 7973 17 the the DT cord-010092-uftc8inx 7973 18 blood blood NN cord-010092-uftc8inx 7973 19 donor donor NN cord-010092-uftc8inx 7973 20 who who WP cord-010092-uftc8inx 7973 21 was be VBD cord-010092-uftc8inx 7973 22 a a DT cord-010092-uftc8inx 7973 23 family family NN cord-010092-uftc8inx 7973 24 relative relative NN cord-010092-uftc8inx 7973 25 . . . cord-010092-uftc8inx 7974 1 The the DT cord-010092-uftc8inx 7974 2 samples sample NNS cord-010092-uftc8inx 7974 3 were be VBD cord-010092-uftc8inx 7974 4 tested test VBN cord-010092-uftc8inx 7974 5 by by IN cord-010092-uftc8inx 7974 6 highly highly RB cord-010092-uftc8inx 7974 7 sensitive sensitive JJ cord-010092-uftc8inx 7974 8 chemiluminescence chemiluminescence NN cord-010092-uftc8inx 7974 9 immunoassay immunoassay NN cord-010092-uftc8inx 7974 10 ( ( -LRB- cord-010092-uftc8inx 7974 11 CLIA CLIA NNP cord-010092-uftc8inx 7974 12 ) ) -RRB- cord-010092-uftc8inx 7974 13 . . . cord-010092-uftc8inx 7975 1 The the DT cord-010092-uftc8inx 7975 2 CLIA CLIA NNP cord-010092-uftc8inx 7975 3 results result NNS cord-010092-uftc8inx 7975 4 confirmed confirm VBD cord-010092-uftc8inx 7975 5 the the DT cord-010092-uftc8inx 7975 6 presence presence NN cord-010092-uftc8inx 7975 7 of of IN cord-010092-uftc8inx 7975 8 HIV HIV NNP cord-010092-uftc8inx 7975 9 in in IN cord-010092-uftc8inx 7975 10 both both DT cord-010092-uftc8inx 7975 11 recipients recipient NNS cord-010092-uftc8inx 7975 12 and and CC cord-010092-uftc8inx 7975 13 the the DT cord-010092-uftc8inx 7975 14 blood blood NN cord-010092-uftc8inx 7975 15 donor donor NN cord-010092-uftc8inx 7975 16 . . . cord-010092-uftc8inx 7976 1 Due due IN cord-010092-uftc8inx 7976 2 to to IN cord-010092-uftc8inx 7976 3 maternal maternal JJ cord-010092-uftc8inx 7976 4 HIV HIV NNP cord-010092-uftc8inx 7976 5 antibodies antibody NNS cord-010092-uftc8inx 7976 6 transfer transfer VBP cord-010092-uftc8inx 7976 7 through through IN cord-010092-uftc8inx 7976 8 the the DT cord-010092-uftc8inx 7976 9 placenta placenta NN cord-010092-uftc8inx 7976 10 , , , cord-010092-uftc8inx 7976 11 the the DT cord-010092-uftc8inx 7976 12 infection infection NN cord-010092-uftc8inx 7976 13 status status NN cord-010092-uftc8inx 7976 14 of of IN cord-010092-uftc8inx 7976 15 the the DT cord-010092-uftc8inx 7976 16 newborn newborn NN cord-010092-uftc8inx 7976 17 was be VBD cord-010092-uftc8inx 7976 18 not not RB cord-010092-uftc8inx 7976 19 re re VBN cord-010092-uftc8inx 7976 20 - - VBN cord-010092-uftc8inx 7976 21 confirmed confirm VBN cord-010092-uftc8inx 7976 22 as as IN cord-010092-uftc8inx 7976 23 he -PRON- PRP cord-010092-uftc8inx 7976 24 died die VBD cord-010092-uftc8inx 7976 25 within within IN cord-010092-uftc8inx 7976 26 two two CD cord-010092-uftc8inx 7976 27 weeks week NNS cord-010092-uftc8inx 7976 28 . . . cord-010092-uftc8inx 7977 1 The the DT cord-010092-uftc8inx 7977 2 donor donor NN cord-010092-uftc8inx 7977 3 informed inform VBD cord-010092-uftc8inx 7977 4 that that IN cord-010092-uftc8inx 7977 5 he -PRON- PRP cord-010092-uftc8inx 7977 6 had have VBD cord-010092-uftc8inx 7977 7 donated donate VBN cord-010092-uftc8inx 7977 8 22 22 CD cord-010092-uftc8inx 7977 9 times time NNS cord-010092-uftc8inx 7977 10 in in IN cord-010092-uftc8inx 7977 11 the the DT cord-010092-uftc8inx 7977 12 past past JJ cord-010092-uftc8inx 7977 13 few few JJ cord-010092-uftc8inx 7977 14 years year NNS cord-010092-uftc8inx 7977 15 . . . cord-010092-uftc8inx 7978 1 The the DT cord-010092-uftc8inx 7978 2 PBTA PBTA NNP cord-010092-uftc8inx 7978 3 was be VBD cord-010092-uftc8inx 7978 4 able able JJ cord-010092-uftc8inx 7978 5 to to TO cord-010092-uftc8inx 7978 6 trace trace VB cord-010092-uftc8inx 7978 7 only only RB cord-010092-uftc8inx 7978 8 one one CD cord-010092-uftc8inx 7978 9 earlier early JJR cord-010092-uftc8inx 7978 10 donation donation NN cord-010092-uftc8inx 7978 11 three three CD cord-010092-uftc8inx 7978 12 months month NNS cord-010092-uftc8inx 7978 13 ago ago RB cord-010092-uftc8inx 7978 14 . . . cord-010092-uftc8inx 7979 1 The the DT cord-010092-uftc8inx 7979 2 recipient recipient NN cord-010092-uftc8inx 7979 3 ( ( -LRB- cord-010092-uftc8inx 7979 4 a a DT cord-010092-uftc8inx 7979 5 female female NN cord-010092-uftc8inx 7979 6 ) ) -RRB- cord-010092-uftc8inx 7979 7 was be VBD cord-010092-uftc8inx 7979 8 found find VBN cord-010092-uftc8inx 7979 9 , , , cord-010092-uftc8inx 7979 10 tested test VBN cord-010092-uftc8inx 7979 11 by by IN cord-010092-uftc8inx 7979 12 CLIA CLIA NNP cord-010092-uftc8inx 7979 13 and and CC cord-010092-uftc8inx 7979 14 was be VBD cord-010092-uftc8inx 7979 15 found find VBN cord-010092-uftc8inx 7979 16 to to TO cord-010092-uftc8inx 7979 17 be be VB cord-010092-uftc8inx 7979 18 HIV HIV NNP cord-010092-uftc8inx 7979 19 positive positive JJ cord-010092-uftc8inx 7979 20 . . . cord-010092-uftc8inx 7980 1 All all PDT cord-010092-uftc8inx 7980 2 these these DT cord-010092-uftc8inx 7980 3 cases case NNS cord-010092-uftc8inx 7980 4 occurred occur VBD cord-010092-uftc8inx 7980 5 in in IN cord-010092-uftc8inx 7980 6 unlicensed unlicensed JJ cord-010092-uftc8inx 7980 7 private private JJ cord-010092-uftc8inx 7980 8 blood blood NN cord-010092-uftc8inx 7980 9 banks bank NNS cord-010092-uftc8inx 7980 10 that that WDT cord-010092-uftc8inx 7980 11 were be VBD cord-010092-uftc8inx 7980 12 screening screen VBG cord-010092-uftc8inx 7980 13 for for IN cord-010092-uftc8inx 7980 14 HIV HIV NNP cord-010092-uftc8inx 7980 15 on on IN cord-010092-uftc8inx 7980 16 rapid rapid JJ cord-010092-uftc8inx 7980 17 manual manual JJ cord-010092-uftc8inx 7980 18 devices device NNS cord-010092-uftc8inx 7980 19 . . . cord-010092-uftc8inx 7981 1 The the DT cord-010092-uftc8inx 7981 2 blood blood NN cord-010092-uftc8inx 7981 3 banks bank NNS cord-010092-uftc8inx 7981 4 were be VBD cord-010092-uftc8inx 7981 5 sealed seal VBN cord-010092-uftc8inx 7981 6 by by IN cord-010092-uftc8inx 7981 7 the the DT cord-010092-uftc8inx 7981 8 Authority Authority NNP cord-010092-uftc8inx 7981 9 and and CC cord-010092-uftc8inx 7981 10 infected infected JJ cord-010092-uftc8inx 7981 11 cases case NNS cord-010092-uftc8inx 7981 12 were be VBD cord-010092-uftc8inx 7981 13 registered register VBN cord-010092-uftc8inx 7981 14 by by IN cord-010092-uftc8inx 7981 15 the the DT cord-010092-uftc8inx 7981 16 provincial provincial JJ cord-010092-uftc8inx 7981 17 AIDS AIDS NNP cord-010092-uftc8inx 7981 18 Control Control NNP cord-010092-uftc8inx 7981 19 Programme Programme NNP cord-010092-uftc8inx 7981 20 and and CC cord-010092-uftc8inx 7981 21 are be VBP cord-010092-uftc8inx 7981 22 being be VBG cord-010092-uftc8inx 7981 23 treated treat VBN cord-010092-uftc8inx 7981 24 . . . cord-010092-uftc8inx 7982 1 Summary Summary NNP cord-010092-uftc8inx 7982 2 / / SYM cord-010092-uftc8inx 7982 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 7982 4 : : : cord-010092-uftc8inx 7983 1 The the DT cord-010092-uftc8inx 7983 2 main main JJ cord-010092-uftc8inx 7983 3 reasons reason NNS cord-010092-uftc8inx 7983 4 for for IN cord-010092-uftc8inx 7983 5 HIV HIV NNP cord-010092-uftc8inx 7983 6 spread spread VBD cord-010092-uftc8inx 7983 7 through through IN cord-010092-uftc8inx 7983 8 blood blood NN cord-010092-uftc8inx 7983 9 transfusion transfusion NN cord-010092-uftc8inx 7983 10 is be VBZ cord-010092-uftc8inx 7983 11 the the DT cord-010092-uftc8inx 7983 12 use use NN cord-010092-uftc8inx 7983 13 of of IN cord-010092-uftc8inx 7983 14 sub sub JJ cord-010092-uftc8inx 7983 15 - - JJ cord-010092-uftc8inx 7983 16 standard standard JJ cord-010092-uftc8inx 7983 17 rapid rapid JJ cord-010092-uftc8inx 7983 18 screening screening NN cord-010092-uftc8inx 7983 19 devices device NNS cord-010092-uftc8inx 7983 20 which which WDT cord-010092-uftc8inx 7983 21 are be VBP cord-010092-uftc8inx 7983 22 not not RB cord-010092-uftc8inx 7983 23 evaluated evaluate VBN cord-010092-uftc8inx 7983 24 and and CC cord-010092-uftc8inx 7983 25 validated validate VBN cord-010092-uftc8inx 7983 26 at at IN cord-010092-uftc8inx 7983 27 a a DT cord-010092-uftc8inx 7983 28 national national JJ cord-010092-uftc8inx 7983 29 level level NN cord-010092-uftc8inx 7983 30 . . . cord-010092-uftc8inx 7984 1 In in IN cord-010092-uftc8inx 7984 2 addition addition NN cord-010092-uftc8inx 7984 3 , , , cord-010092-uftc8inx 7984 4 the the DT cord-010092-uftc8inx 7984 5 existing exist VBG cord-010092-uftc8inx 7984 6 system system NN cord-010092-uftc8inx 7984 7 relies rely VBZ cord-010092-uftc8inx 7984 8 on on IN cord-010092-uftc8inx 7984 9 the the DT cord-010092-uftc8inx 7984 10 family family NN cord-010092-uftc8inx 7984 11 / / SYM cord-010092-uftc8inx 7984 12 replacement replacement NN cord-010092-uftc8inx 7984 13 donors donor NNS cord-010092-uftc8inx 7984 14 . . . cord-010092-uftc8inx 7985 1 The the DT cord-010092-uftc8inx 7985 2 national national JJ cord-010092-uftc8inx 7985 3 Safe Safe NNP cord-010092-uftc8inx 7985 4 Blood Blood NNP cord-010092-uftc8inx 7985 5 Transfusion Transfusion NNP cord-010092-uftc8inx 7985 6 Programme Programme NNP cord-010092-uftc8inx 7985 7 , , , cord-010092-uftc8inx 7985 8 is be VBZ cord-010092-uftc8inx 7985 9 implementing implement VBG cord-010092-uftc8inx 7985 10 blood blood NN cord-010092-uftc8inx 7985 11 safety safety NN cord-010092-uftc8inx 7985 12 system system NN cord-010092-uftc8inx 7985 13 reforms reform NNS cord-010092-uftc8inx 7985 14 as as IN cord-010092-uftc8inx 7985 15 recommended recommend VBN cord-010092-uftc8inx 7985 16 by by IN cord-010092-uftc8inx 7985 17 WHO WHO NNP cord-010092-uftc8inx 7985 18 . . . cord-010092-uftc8inx 7986 1 Under under IN cord-010092-uftc8inx 7986 2 the the DT cord-010092-uftc8inx 7986 3 reform reform NN cord-010092-uftc8inx 7986 4 agenda agenda NN cord-010092-uftc8inx 7986 5 , , , cord-010092-uftc8inx 7986 6 the the DT cord-010092-uftc8inx 7986 7 blood blood NN cord-010092-uftc8inx 7986 8 transfusion transfusion NN cord-010092-uftc8inx 7986 9 authorities authority NNS cord-010092-uftc8inx 7986 10 have have VBP cord-010092-uftc8inx 7986 11 been be VBN cord-010092-uftc8inx 7986 12 made make VBN cord-010092-uftc8inx 7986 13 functional functional JJ cord-010092-uftc8inx 7986 14 and and CC cord-010092-uftc8inx 7986 15 grant grant VB cord-010092-uftc8inx 7986 16 licenses license NNS cord-010092-uftc8inx 7986 17 to to TO cord-010092-uftc8inx 7986 18 only only RB cord-010092-uftc8inx 7986 19 those those DT cord-010092-uftc8inx 7986 20 blood blood NN cord-010092-uftc8inx 7986 21 banks bank NNS cord-010092-uftc8inx 7986 22 with with IN cord-010092-uftc8inx 7986 23 proper proper JJ cord-010092-uftc8inx 7986 24 systems system NNS cord-010092-uftc8inx 7986 25 to to TO cord-010092-uftc8inx 7986 26 ensure ensure VB cord-010092-uftc8inx 7986 27 quality quality NN cord-010092-uftc8inx 7986 28 and and CC cord-010092-uftc8inx 7986 29 safety safety NN cord-010092-uftc8inx 7986 30 of of IN cord-010092-uftc8inx 7986 31 blood blood NN cord-010092-uftc8inx 7986 32 products product NNS cord-010092-uftc8inx 7986 33 . . . cord-010092-uftc8inx 7987 1 The the DT cord-010092-uftc8inx 7987 2 Programme Programme NNP cord-010092-uftc8inx 7987 3 is be VBZ cord-010092-uftc8inx 7987 4 developing develop VBG cord-010092-uftc8inx 7987 5 a a DT cord-010092-uftc8inx 7987 6 national national JJ cord-010092-uftc8inx 7987 7 system system NN cord-010092-uftc8inx 7987 8 for for IN cord-010092-uftc8inx 7987 9 the the DT cord-010092-uftc8inx 7987 10 evaluation evaluation NN cord-010092-uftc8inx 7987 11 , , , cord-010092-uftc8inx 7987 12 selection selection NN cord-010092-uftc8inx 7987 13 and and CC cord-010092-uftc8inx 7987 14 validation validation NN cord-010092-uftc8inx 7987 15 of of IN cord-010092-uftc8inx 7987 16 all all DT cord-010092-uftc8inx 7987 17 assays assay NNS cord-010092-uftc8inx 7987 18 used use VBN cord-010092-uftc8inx 7987 19 for for IN cord-010092-uftc8inx 7987 20 screening screening NN cord-010092-uftc8inx 7987 21 of of IN cord-010092-uftc8inx 7987 22 blood blood NN cord-010092-uftc8inx 7987 23 in in IN cord-010092-uftc8inx 7987 24 close close JJ cord-010092-uftc8inx 7987 25 coordination coordination NN cord-010092-uftc8inx 7987 26 with with IN cord-010092-uftc8inx 7987 27 the the DT cord-010092-uftc8inx 7987 28 Drug Drug NNP cord-010092-uftc8inx 7987 29 Regulatory Regulatory NNP cord-010092-uftc8inx 7987 30 Authority Authority NNP cord-010092-uftc8inx 7987 31 of of IN cord-010092-uftc8inx 7987 32 Pakistan Pakistan NNP cord-010092-uftc8inx 7987 33 . . . cord-010092-uftc8inx 7988 1 To to TO cord-010092-uftc8inx 7988 2 promote promote VB cord-010092-uftc8inx 7988 3 the the DT cord-010092-uftc8inx 7988 4 culture culture NN cord-010092-uftc8inx 7988 5 of of IN cord-010092-uftc8inx 7988 6 voluntary voluntary JJ cord-010092-uftc8inx 7988 7 blood blood NN cord-010092-uftc8inx 7988 8 donations donation NNS cord-010092-uftc8inx 7988 9 , , , cord-010092-uftc8inx 7988 10 the the DT cord-010092-uftc8inx 7988 11 Programme Programme NNP cord-010092-uftc8inx 7988 12 has have VBZ cord-010092-uftc8inx 7988 13 taken take VBN cord-010092-uftc8inx 7988 14 concrete concrete JJ cord-010092-uftc8inx 7988 15 steps step NNS cord-010092-uftc8inx 7988 16 initiating initiate VBG cord-010092-uftc8inx 7988 17 with with IN cord-010092-uftc8inx 7988 18 the the DT cord-010092-uftc8inx 7988 19 formulation formulation NN cord-010092-uftc8inx 7988 20 of of IN cord-010092-uftc8inx 7988 21 a a DT cord-010092-uftc8inx 7988 22 national national JJ cord-010092-uftc8inx 7988 23 blood blood NN cord-010092-uftc8inx 7988 24 donor donor NN cord-010092-uftc8inx 7988 25 policy policy NN cord-010092-uftc8inx 7988 26 , , , cord-010092-uftc8inx 7988 27 interaction interaction NN cord-010092-uftc8inx 7988 28 with with IN cord-010092-uftc8inx 7988 29 celebrities celebrity NNS cord-010092-uftc8inx 7988 30 , , , cord-010092-uftc8inx 7988 31 celebration celebration NN cord-010092-uftc8inx 7988 32 of of IN cord-010092-uftc8inx 7988 33 world world NN cord-010092-uftc8inx 7988 34 blood blood NN cord-010092-uftc8inx 7988 35 donor donor NN cord-010092-uftc8inx 7988 36 day day NN cord-010092-uftc8inx 7988 37 and and CC cord-010092-uftc8inx 7988 38 more more JJR cord-010092-uftc8inx 7988 39 recently recently RB cord-010092-uftc8inx 7988 40 the the DT cord-010092-uftc8inx 7988 41 launch launch NN cord-010092-uftc8inx 7988 42 of of IN cord-010092-uftc8inx 7988 43 blood blood NN cord-010092-uftc8inx 7988 44 donation donation NN cord-010092-uftc8inx 7988 45 feature feature VBP cord-010092-uftc8inx 7988 46 through through IN cord-010092-uftc8inx 7988 47 ' ' `` cord-010092-uftc8inx 7988 48 Facebook Facebook NNP cord-010092-uftc8inx 7988 49 ' ' '' cord-010092-uftc8inx 7988 50 . . . cord-010092-uftc8inx 7989 1 The the DT cord-010092-uftc8inx 7989 2 promotion promotion NN cord-010092-uftc8inx 7989 3 of of IN cord-010092-uftc8inx 7989 4 voluntary voluntary JJ cord-010092-uftc8inx 7989 5 blood blood NN cord-010092-uftc8inx 7989 6 donation donation NN cord-010092-uftc8inx 7989 7 concept concept NN cord-010092-uftc8inx 7989 8 along along IN cord-010092-uftc8inx 7989 9 with with IN cord-010092-uftc8inx 7989 10 regulation regulation NN cord-010092-uftc8inx 7989 11 of of IN cord-010092-uftc8inx 7989 12 blood blood NN cord-010092-uftc8inx 7989 13 sector sector NN cord-010092-uftc8inx 7989 14 will will MD cord-010092-uftc8inx 7989 15 reduce reduce VB cord-010092-uftc8inx 7989 16 the the DT cord-010092-uftc8inx 7989 17 risk risk NN cord-010092-uftc8inx 7989 18 of of IN cord-010092-uftc8inx 7989 19 HIV HIV NNP cord-010092-uftc8inx 7989 20 transmission transmission NN cord-010092-uftc8inx 7989 21 through through IN cord-010092-uftc8inx 7989 22 blood blood NN cord-010092-uftc8inx 7989 23 transfusions transfusion NNS cord-010092-uftc8inx 7989 24 in in IN cord-010092-uftc8inx 7989 25 Pakistan Pakistan NNP cord-010092-uftc8inx 7989 26 . . . cord-010092-uftc8inx 7990 1 Mianyang Mianyang NNP cord-010092-uftc8inx 7990 2 Blood Blood NNP cord-010092-uftc8inx 7990 3 Center Center NNP cord-010092-uftc8inx 7990 4 , , , cord-010092-uftc8inx 7990 5 Mianyang Mianyang NNP cord-010092-uftc8inx 7990 6 9 9 CD cord-010092-uftc8inx 7990 7 Urumqi Urumqi NNP cord-010092-uftc8inx 7990 8 Blood Blood NNP cord-010092-uftc8inx 7990 9 Center Center NNP cord-010092-uftc8inx 7990 10 , , , cord-010092-uftc8inx 7990 11 Urumqi Urumqi NNP cord-010092-uftc8inx 7990 12 , , , cord-010092-uftc8inx 7990 13 China China NNP cord-010092-uftc8inx 7990 14 10 10 CD cord-010092-uftc8inx 7990 15 RTI RTI NNP cord-010092-uftc8inx 7990 16 International International NNP cord-010092-uftc8inx 7990 17 , , , cord-010092-uftc8inx 7990 18 Rockville Rockville NNP cord-010092-uftc8inx 7990 19 11 11 CD cord-010092-uftc8inx 7990 20 National National NNP cord-010092-uftc8inx 7990 21 Heart Heart NNP cord-010092-uftc8inx 7990 22 , , , cord-010092-uftc8inx 7990 23 Lung Lung NNP cord-010092-uftc8inx 7990 24 , , , cord-010092-uftc8inx 7990 25 and and CC cord-010092-uftc8inx 7990 26 Blood Blood NNP cord-010092-uftc8inx 7990 27 Institute Institute NNP cord-010092-uftc8inx 7990 28 , , , cord-010092-uftc8inx 7990 29 Bethesda Bethesda NNP cord-010092-uftc8inx 7990 30 12 12 CD cord-010092-uftc8inx 7990 31 Stanford Stanford NNP cord-010092-uftc8inx 7990 32 University University NNP cord-010092-uftc8inx 7990 33 , , , cord-010092-uftc8inx 7990 34 Stanford Stanford NNP cord-010092-uftc8inx 7990 35 , , , cord-010092-uftc8inx 7991 1 United United NNP cord-010092-uftc8inx 7991 2 States States NNP cord-010092-uftc8inx 7991 3 Background Background NNP cord-010092-uftc8inx 7991 4 : : : cord-010092-uftc8inx 7992 1 The the DT cord-010092-uftc8inx 7992 2 incidence incidence NN cord-010092-uftc8inx 7992 3 of of IN cord-010092-uftc8inx 7992 4 HIV HIV NNP cord-010092-uftc8inx 7992 5 infections infection NNS cord-010092-uftc8inx 7992 6 has have VBZ cord-010092-uftc8inx 7992 7 increased increase VBN cord-010092-uftc8inx 7992 8 substantially substantially RB cord-010092-uftc8inx 7992 9 over over IN cord-010092-uftc8inx 7992 10 the the DT cord-010092-uftc8inx 7992 11 past past JJ cord-010092-uftc8inx 7992 12 decade decade NN cord-010092-uftc8inx 7992 13 in in IN cord-010092-uftc8inx 7992 14 China China NNP cord-010092-uftc8inx 7992 15 , , , cord-010092-uftc8inx 7992 16 especially especially RB cord-010092-uftc8inx 7992 17 among among IN cord-010092-uftc8inx 7992 18 young young JJ cord-010092-uftc8inx 7992 19 people people NNS cord-010092-uftc8inx 7992 20 , , , cord-010092-uftc8inx 7992 21 who who WP cord-010092-uftc8inx 7992 22 represent represent VBP cord-010092-uftc8inx 7992 23 nearly nearly RB cord-010092-uftc8inx 7992 24 half half NN cord-010092-uftc8inx 7992 25 of of IN cord-010092-uftc8inx 7992 26 the the DT cord-010092-uftc8inx 7992 27 Chinese chinese JJ cord-010092-uftc8inx 7992 28 blood blood NN cord-010092-uftc8inx 7992 29 donor donor NN cord-010092-uftc8inx 7992 30 population population NN cord-010092-uftc8inx 7992 31 . . . cord-010092-uftc8inx 7993 1 This this DT cord-010092-uftc8inx 7993 2 upward upward JJ cord-010092-uftc8inx 7993 3 trend trend NN cord-010092-uftc8inx 7993 4 in in IN cord-010092-uftc8inx 7993 5 HIV HIV NNP cord-010092-uftc8inx 7993 6 infections infection NNS cord-010092-uftc8inx 7993 7 underscores underscore VBZ cord-010092-uftc8inx 7993 8 the the DT cord-010092-uftc8inx 7993 9 importance importance NN cord-010092-uftc8inx 7993 10 of of IN cord-010092-uftc8inx 7993 11 monitoring monitor VBG cord-010092-uftc8inx 7993 12 HIV HIV NNP cord-010092-uftc8inx 7993 13 prevalence prevalence NN cord-010092-uftc8inx 7993 14 and and CC cord-010092-uftc8inx 7993 15 incidence incidence NN cord-010092-uftc8inx 7993 16 in in IN cord-010092-uftc8inx 7993 17 Chinese chinese JJ cord-010092-uftc8inx 7993 18 blood blood NN cord-010092-uftc8inx 7993 19 donors donor NNS cord-010092-uftc8inx 7993 20 . . . cord-010092-uftc8inx 7994 1 Aims aim VBZ cord-010092-uftc8inx 7994 2 : : : cord-010092-uftc8inx 7995 1 To to TO cord-010092-uftc8inx 7995 2 estimate estimate VB cord-010092-uftc8inx 7995 3 HIV HIV NNP cord-010092-uftc8inx 7995 4 prevalence prevalence NN cord-010092-uftc8inx 7995 5 and and CC cord-010092-uftc8inx 7995 6 incidence incidence NN cord-010092-uftc8inx 7995 7 rate rate NN cord-010092-uftc8inx 7995 8 ( ( -LRB- cord-010092-uftc8inx 7995 9 IR IR NNP cord-010092-uftc8inx 7995 10 ) ) -RRB- cord-010092-uftc8inx 7995 11 among among IN cord-010092-uftc8inx 7995 12 Chinese chinese JJ cord-010092-uftc8inx 7995 13 blood blood NN cord-010092-uftc8inx 7995 14 donors donor NNS cord-010092-uftc8inx 7995 15 using use VBG cord-010092-uftc8inx 7995 16 blood blood NN cord-010092-uftc8inx 7995 17 donation donation NN cord-010092-uftc8inx 7995 18 data datum NNS cord-010092-uftc8inx 7995 19 from from IN cord-010092-uftc8inx 7995 20 five five CD cord-010092-uftc8inx 7995 21 geographically geographically RB cord-010092-uftc8inx 7995 22 - - HYPH cord-010092-uftc8inx 7995 23 disperse disperse VB cord-010092-uftc8inx 7995 24 blood blood NN cord-010092-uftc8inx 7995 25 centers center NNS cord-010092-uftc8inx 7995 26 in in IN cord-010092-uftc8inx 7995 27 2013 2013 CD cord-010092-uftc8inx 7995 28 - - SYM cord-010092-uftc8inx 7995 29 2016 2016 CD cord-010092-uftc8inx 7995 30 participating participate VBG cord-010092-uftc8inx 7995 31 in in IN cord-010092-uftc8inx 7995 32 the the DT cord-010092-uftc8inx 7995 33 Recipient Recipient NNP cord-010092-uftc8inx 7995 34 Epidemiology Epidemiology NNP cord-010092-uftc8inx 7995 35 and and CC cord-010092-uftc8inx 7995 36 Donor Donor NNP cord-010092-uftc8inx 7995 37 Evaluation Evaluation NNP cord-010092-uftc8inx 7995 38 Study Study NNP cord-010092-uftc8inx 7995 39 - - HYPH cord-010092-uftc8inx 7995 40 III III NNP cord-010092-uftc8inx 7995 41 ( ( -LRB- cord-010092-uftc8inx 7995 42 REDS REDS NNP cord-010092-uftc8inx 7995 43 - - HYPH cord-010092-uftc8inx 7995 44 III III NNP cord-010092-uftc8inx 7995 45 ) ) -RRB- cord-010092-uftc8inx 7996 1 China China NNP cord-010092-uftc8inx 7996 2 program program NN cord-010092-uftc8inx 7996 3 . . . cord-010092-uftc8inx 7997 1 Methods method NNS cord-010092-uftc8inx 7997 2 : : : cord-010092-uftc8inx 7997 3 Western western JJ cord-010092-uftc8inx 7997 4 blot blot NN cord-010092-uftc8inx 7998 1 confirmatory confirmatory JJ cord-010092-uftc8inx 7998 2 testing testing NN cord-010092-uftc8inx 7998 3 was be VBD cord-010092-uftc8inx 7998 4 done do VBN cord-010092-uftc8inx 7998 5 on on IN cord-010092-uftc8inx 7998 6 samples sample NNS cord-010092-uftc8inx 7998 7 of of IN cord-010092-uftc8inx 7998 8 blood blood NN cord-010092-uftc8inx 7998 9 donations donation NNS cord-010092-uftc8inx 7998 10 reactive reactive JJ cord-010092-uftc8inx 7998 11 for for IN cord-010092-uftc8inx 7998 12 HIV-1/2 hiv-1/2 NN cord-010092-uftc8inx 7998 13 on on IN cord-010092-uftc8inx 7998 14 one one CD cord-010092-uftc8inx 7998 15 or or CC cord-010092-uftc8inx 7998 16 both both DT cord-010092-uftc8inx 7998 17 rounds round NNS cord-010092-uftc8inx 7998 18 of of IN cord-010092-uftc8inx 7998 19 routine routine JJ cord-010092-uftc8inx 7998 20 ELISA ELISA NNP cord-010092-uftc8inx 7998 21 tests test NNS cord-010092-uftc8inx 7998 22 or or CC cord-010092-uftc8inx 7998 23 positive positive JJ cord-010092-uftc8inx 7998 24 by by IN cord-010092-uftc8inx 7998 25 Nucleic nucleic JJ cord-010092-uftc8inx 7998 26 Acid acid NN cord-010092-uftc8inx 7998 27 Amplification amplification NN cord-010092-uftc8inx 7998 28 Testing testing NN cord-010092-uftc8inx 7998 29 ( ( -LRB- cord-010092-uftc8inx 7998 30 NAT NAT NNP cord-010092-uftc8inx 7998 31 ) ) -RRB- cord-010092-uftc8inx 7998 32 . . . cord-010092-uftc8inx 7999 1 Multiple multiple JJ cord-010092-uftc8inx 7999 2 imputation imputation NN cord-010092-uftc8inx 7999 3 was be VBD cord-010092-uftc8inx 7999 4 used use VBN cord-010092-uftc8inx 7999 5 for for IN cord-010092-uftc8inx 7999 6 samples sample NNS cord-010092-uftc8inx 7999 7 with with IN cord-010092-uftc8inx 7999 8 missing miss VBG cord-010092-uftc8inx 7999 9 confirmatory confirmatory JJ cord-010092-uftc8inx 7999 10 test test NN cord-010092-uftc8inx 7999 11 results result NNS cord-010092-uftc8inx 7999 12 . . . cord-010092-uftc8inx 8000 1 HIV HIV NNP cord-010092-uftc8inx 8000 2 prevalence prevalence NN cord-010092-uftc8inx 8000 3 was be VBD cord-010092-uftc8inx 8000 4 calculated calculate VBN cord-010092-uftc8inx 8000 5 among among IN cord-010092-uftc8inx 8000 6 first first JJ cord-010092-uftc8inx 8000 7 - - HYPH cord-010092-uftc8inx 8000 8 time time NN cord-010092-uftc8inx 8000 9 donors donor NNS cord-010092-uftc8inx 8000 10 . . . cord-010092-uftc8inx 8001 1 To to TO cord-010092-uftc8inx 8001 2 estimate estimate VB cord-010092-uftc8inx 8001 3 HIV HIV NNP cord-010092-uftc8inx 8001 4 IR IR NNP cord-010092-uftc8inx 8001 5 in in IN cord-010092-uftc8inx 8001 6 first first JJ cord-010092-uftc8inx 8001 7 - - HYPH cord-010092-uftc8inx 8001 8 time time NN cord-010092-uftc8inx 8001 9 donors donor NNS cord-010092-uftc8inx 8001 10 , , , cord-010092-uftc8inx 8001 11 single single JJ cord-010092-uftc8inx 8001 12 - - HYPH cord-010092-uftc8inx 8001 13 well well NN cord-010092-uftc8inx 8001 14 LAg LAg NNS cord-010092-uftc8inx 8001 15 - - HYPH cord-010092-uftc8inx 8001 16 Avidity avidity NN cord-010092-uftc8inx 8001 17 EIA EIA NNP cord-010092-uftc8inx 8001 18 testing testing NN cord-010092-uftc8inx 8001 19 was be VBD cord-010092-uftc8inx 8001 20 conducted conduct VBN cord-010092-uftc8inx 8001 21 with with IN cord-010092-uftc8inx 8001 22 first first JJ cord-010092-uftc8inx 8001 23 - - HYPH cord-010092-uftc8inx 8001 24 time time NN cord-010092-uftc8inx 8001 25 HIV HIV NNP cord-010092-uftc8inx 8001 26 recent recent JJ cord-010092-uftc8inx 8001 27 ( ( -LRB- cord-010092-uftc8inx 8001 28 incident incident NN cord-010092-uftc8inx 8001 29 ) ) -RRB- cord-010092-uftc8inx 8001 30 infections infection NNS cord-010092-uftc8inx 8001 31 defined define VBN cord-010092-uftc8inx 8001 32 as as IN cord-010092-uftc8inx 8001 33 being be VBG cord-010092-uftc8inx 8001 34 infected infect VBN cord-010092-uftc8inx 8001 35 within within IN cord-010092-uftc8inx 8001 36 approximately approximately RB cord-010092-uftc8inx 8001 37 129 129 CD cord-010092-uftc8inx 8001 38 days day NNS cord-010092-uftc8inx 8001 39 based base VBN cord-010092-uftc8inx 8001 40 on on IN cord-010092-uftc8inx 8001 41 avidity avidity NN cord-010092-uftc8inx 8001 42 of of IN cord-010092-uftc8inx 8001 43 HIV HIV NNP cord-010092-uftc8inx 8001 44 antibodies antibody NNS cord-010092-uftc8inx 8001 45 . . . cord-010092-uftc8inx 8002 1 A a DT cord-010092-uftc8inx 8002 2 novel novel JJ cord-010092-uftc8inx 8002 3 model model NN cord-010092-uftc8inx 8002 4 was be VBD cord-010092-uftc8inx 8002 5 derived derive VBN cord-010092-uftc8inx 8002 6 to to TO cord-010092-uftc8inx 8002 7 estimate estimate VB cord-010092-uftc8inx 8002 8 HIV HIV NNP cord-010092-uftc8inx 8002 9 IR IR NNP cord-010092-uftc8inx 8002 10 among among IN cord-010092-uftc8inx 8002 11 infrequent infrequent JJ cord-010092-uftc8inx 8002 12 repeat repeat NN cord-010092-uftc8inx 8002 13 donors donor NNS cord-010092-uftc8inx 8002 14 who who WP cord-010092-uftc8inx 8002 15 had have VBD cord-010092-uftc8inx 8002 16 provided provide VBN cord-010092-uftc8inx 8002 17 only only RB cord-010092-uftc8inx 8002 18 one one CD cord-010092-uftc8inx 8002 19 donation donation NN cord-010092-uftc8inx 8002 20 in in IN cord-010092-uftc8inx 8002 21 the the DT cord-010092-uftc8inx 8002 22 2013 2013 CD cord-010092-uftc8inx 8002 23 - - SYM cord-010092-uftc8inx 8002 24 2016 2016 CD cord-010092-uftc8inx 8002 25 estimation estimation NN cord-010092-uftc8inx 8002 26 interval interval NN cord-010092-uftc8inx 8002 27 . . . cord-010092-uftc8inx 8003 1 To to TO cord-010092-uftc8inx 8003 2 derive derive VB cord-010092-uftc8inx 8003 3 an an DT cord-010092-uftc8inx 8003 4 overall overall JJ cord-010092-uftc8inx 8003 5 HIV HIV NNP cord-010092-uftc8inx 8003 6 IR IR NNP cord-010092-uftc8inx 8003 7 for for IN cord-010092-uftc8inx 8003 8 repeat repeat NN cord-010092-uftc8inx 8003 9 donors donor NNS cord-010092-uftc8inx 8003 10 , , , cord-010092-uftc8inx 8003 11 this this DT cord-010092-uftc8inx 8003 12 estimate estimate NN cord-010092-uftc8inx 8003 13 was be VBD cord-010092-uftc8inx 8003 14 combined combine VBN cord-010092-uftc8inx 8003 15 with with IN cord-010092-uftc8inx 8003 16 the the DT cord-010092-uftc8inx 8003 17 classical classical JJ cord-010092-uftc8inx 8003 18 - - HYPH cord-010092-uftc8inx 8003 19 model model NN cord-010092-uftc8inx 8003 20 IR IR NNP cord-010092-uftc8inx 8003 21 estimated estimate VBD cord-010092-uftc8inx 8003 22 for for IN cord-010092-uftc8inx 8003 23 repeat repeat NN cord-010092-uftc8inx 8003 24 donors donor NNS cord-010092-uftc8inx 8003 25 who who WP cord-010092-uftc8inx 8003 26 had have VBD cord-010092-uftc8inx 8003 27 given give VBN cord-010092-uftc8inx 8003 28 at at IN cord-010092-uftc8inx 8003 29 least least JJS cord-010092-uftc8inx 8003 30 2 2 CD cord-010092-uftc8inx 8003 31 donations donation NNS cord-010092-uftc8inx 8003 32 in in IN cord-010092-uftc8inx 8003 33 the the DT cord-010092-uftc8inx 8003 34 estimation estimation NN cord-010092-uftc8inx 8003 35 interval interval NN cord-010092-uftc8inx 8003 36 . . . cord-010092-uftc8inx 8004 1 Multivariable multivariable JJ cord-010092-uftc8inx 8004 2 logistic logistic JJ cord-010092-uftc8inx 8004 3 regression regression NN cord-010092-uftc8inx 8004 4 model model NN cord-010092-uftc8inx 8004 5 was be VBD cord-010092-uftc8inx 8004 6 used use VBN cord-010092-uftc8inx 8004 7 to to TO cord-010092-uftc8inx 8004 8 examine examine VB cord-010092-uftc8inx 8004 9 factors factor NNS cord-010092-uftc8inx 8004 10 associated associate VBN cord-010092-uftc8inx 8004 11 with with IN cord-010092-uftc8inx 8004 12 HIV HIV NNP cord-010092-uftc8inx 8004 13 infection infection NN cord-010092-uftc8inx 8004 14 . . . cord-010092-uftc8inx 8005 1 Results result NNS cord-010092-uftc8inx 8005 2 : : : cord-010092-uftc8inx 8006 1 A a DT cord-010092-uftc8inx 8006 2 total total NN cord-010092-uftc8inx 8006 3 of of IN cord-010092-uftc8inx 8006 4 1,276,544 1,276,544 CD cord-010092-uftc8inx 8006 5 whole whole JJ cord-010092-uftc8inx 8006 6 blood blood NN cord-010092-uftc8inx 8006 7 and and CC cord-010092-uftc8inx 8006 8 apheresis apheresis NN cord-010092-uftc8inx 8006 9 platelet platelet NN cord-010092-uftc8inx 8006 10 donations donation NNS cord-010092-uftc8inx 8006 11 with with IN cord-010092-uftc8inx 8006 12 postdonation postdonation NN cord-010092-uftc8inx 8006 13 screening screening NN cord-010092-uftc8inx 8006 14 results result NNS cord-010092-uftc8inx 8006 15 were be VBD cord-010092-uftc8inx 8006 16 collected collect VBN cord-010092-uftc8inx 8006 17 at at IN cord-010092-uftc8inx 8006 18 the the DT cord-010092-uftc8inx 8006 19 five five CD cord-010092-uftc8inx 8006 20 blood blood NN cord-010092-uftc8inx 8006 21 centers center NNS cord-010092-uftc8inx 8006 22 between between IN cord-010092-uftc8inx 8006 23 2013 2013 CD cord-010092-uftc8inx 8006 24 and and CC cord-010092-uftc8inx 8006 25 2016 2016 CD cord-010092-uftc8inx 8006 26 , , , cord-010092-uftc8inx 8006 27 including include VBG cord-010092-uftc8inx 8006 28 648,607 648,607 CD cord-010092-uftc8inx 8006 29 donations donation NNS cord-010092-uftc8inx 8006 30 from from IN cord-010092-uftc8inx 8006 31 first first JJ cord-010092-uftc8inx 8006 32 - - HYPH cord-010092-uftc8inx 8006 33 time time NN cord-010092-uftc8inx 8006 34 donors donor NNS cord-010092-uftc8inx 8006 35 and and CC cord-010092-uftc8inx 8006 36 627 627 CD cord-010092-uftc8inx 8006 37 , , , cord-010092-uftc8inx 8006 38 937 937 CD cord-010092-uftc8inx 8006 39 donations donation NNS cord-010092-uftc8inx 8006 40 from from IN cord-010092-uftc8inx 8006 41 repeat repeat NN cord-010092-uftc8inx 8006 42 donors donor NNS cord-010092-uftc8inx 8006 43 . . . cord-010092-uftc8inx 8007 1 HIV HIV NNP cord-010092-uftc8inx 8007 2 prevalence prevalence NN cord-010092-uftc8inx 8007 3 among among IN cord-010092-uftc8inx 8007 4 first first JJ cord-010092-uftc8inx 8007 5 - - HYPH cord-010092-uftc8inx 8007 6 time time NN cord-010092-uftc8inx 8007 7 donors donor NNS cord-010092-uftc8inx 8007 8 was be VBD cord-010092-uftc8inx 8007 9 68.04 68.04 CD cord-010092-uftc8inx 8007 10 per per IN cord-010092-uftc8inx 8007 11 100,000 100,000 CD cord-010092-uftc8inx 8007 12 donors donor NNS cord-010092-uftc8inx 8007 13 ( ( -LRB- cord-010092-uftc8inx 8007 14 95 95 CD cord-010092-uftc8inx 8007 15 % % NN cord-010092-uftc8inx 8007 16 CI CI NNP cord-010092-uftc8inx 8007 17 , , , cord-010092-uftc8inx 8007 18 61.68 61.68 CD cord-010092-uftc8inx 8007 19 - - SYM cord-010092-uftc8inx 8007 20 74.40 74.40 CD cord-010092-uftc8inx 8007 21 ) ) -RRB- cord-010092-uftc8inx 8007 22 . . . cord-010092-uftc8inx 8008 1 HIV HIV NNP cord-010092-uftc8inx 8008 2 IR IR NNP cord-010092-uftc8inx 8008 3 was be VBD cord-010092-uftc8inx 8008 4 estimated estimate VBN cord-010092-uftc8inx 8008 5 to to TO cord-010092-uftc8inx 8008 6 be be VB cord-010092-uftc8inx 8008 7 37.93 37.93 CD cord-010092-uftc8inx 8008 8 per per IN cord-010092-uftc8inx 8008 9 100,000 100,000 CD cord-010092-uftc8inx 8008 10 person person NN cord-010092-uftc8inx 8008 11 - - HYPH cord-010092-uftc8inx 8008 12 years year NNS cord-010092-uftc8inx 8008 13 ( ( -LRB- cord-010092-uftc8inx 8008 14 95 95 CD cord-010092-uftc8inx 8008 15 % % NN cord-010092-uftc8inx 8008 16 CI CI NNP cord-010092-uftc8inx 8008 17 , , , cord-010092-uftc8inx 8008 18 30.62 30.62 CD cord-010092-uftc8inx 8008 19 - - SYM cord-010092-uftc8inx 8008 20 46.97 46.97 CD cord-010092-uftc8inx 8008 21 ) ) -RRB- cord-010092-uftc8inx 8008 22 among among IN cord-010092-uftc8inx 8008 23 first first JJ cord-010092-uftc8inx 8008 24 - - HYPH cord-010092-uftc8inx 8008 25 time time NN cord-010092-uftc8inx 8008 26 donors donor NNS cord-010092-uftc8inx 8008 27 and and CC cord-010092-uftc8inx 8008 28 20.55 20.55 CD cord-010092-uftc8inx 8008 29 per per IN cord-010092-uftc8inx 8008 30 100,000 100,000 CD cord-010092-uftc8inx 8008 31 person person NN cord-010092-uftc8inx 8008 32 - - HYPH cord-010092-uftc8inx 8008 33 years year NNS cord-010092-uftc8inx 8008 34 ( ( -LRB- cord-010092-uftc8inx 8008 35 95 95 CD cord-010092-uftc8inx 8008 36 % % NN cord-010092-uftc8inx 8008 37 CI CI NNP cord-010092-uftc8inx 8008 38 , , , cord-010092-uftc8inx 8008 39 16.95 16.95 CD cord-010092-uftc8inx 8008 40 - - SYM cord-010092-uftc8inx 8008 41 24.91 24.91 CD cord-010092-uftc8inx 8008 42 ) ) -RRB- cord-010092-uftc8inx 8008 43 among among IN cord-010092-uftc8inx 8008 44 repeat repeat NN cord-010092-uftc8inx 8008 45 donors donor NNS cord-010092-uftc8inx 8008 46 . . . cord-010092-uftc8inx 8009 1 HIV HIV NNP cord-010092-uftc8inx 8009 2 prevalence prevalence NN cord-010092-uftc8inx 8009 3 and and CC cord-010092-uftc8inx 8009 4 IR IR NNP cord-010092-uftc8inx 8009 5 varied vary VBN cord-010092-uftc8inx 8009 6 across across IN cord-010092-uftc8inx 8009 7 regions region NNS cord-010092-uftc8inx 8009 8 with with IN cord-010092-uftc8inx 8009 9 an an DT cord-010092-uftc8inx 8009 10 increasing increase VBG cord-010092-uftc8inx 8009 11 trend trend NN cord-010092-uftc8inx 8009 12 observed observe VBD cord-010092-uftc8inx 8009 13 at at IN cord-010092-uftc8inx 8009 14 some some DT cord-010092-uftc8inx 8009 15 blood blood NN cord-010092-uftc8inx 8009 16 centers center NNS cord-010092-uftc8inx 8009 17 . . . cord-010092-uftc8inx 8010 1 Among among IN cord-010092-uftc8inx 8010 2 first first JJ cord-010092-uftc8inx 8010 3 - - HYPH cord-010092-uftc8inx 8010 4 time time NN cord-010092-uftc8inx 8010 5 donors donor NNS cord-010092-uftc8inx 8010 6 , , , cord-010092-uftc8inx 8010 7 being be VBG cord-010092-uftc8inx 8010 8 male male JJ cord-010092-uftc8inx 8010 9 , , , cord-010092-uftc8inx 8010 10 older old JJR cord-010092-uftc8inx 8010 11 than than IN cord-010092-uftc8inx 8010 12 25 25 CD cord-010092-uftc8inx 8010 13 years year NNS cord-010092-uftc8inx 8010 14 , , , cord-010092-uftc8inx 8010 15 minority minority NN cord-010092-uftc8inx 8010 16 ethnicity ethnicity NN cord-010092-uftc8inx 8010 17 , , , cord-010092-uftc8inx 8010 18 less less JJR cord-010092-uftc8inx 8010 19 than than IN cord-010092-uftc8inx 8010 20 college college NN cord-010092-uftc8inx 8010 21 education education NN cord-010092-uftc8inx 8010 22 , , , cord-010092-uftc8inx 8010 23 and and CC cord-010092-uftc8inx 8010 24 certain certain JJ cord-010092-uftc8inx 8010 25 occupations occupation NNS cord-010092-uftc8inx 8010 26 ( ( -LRB- cord-010092-uftc8inx 8010 27 commercial commercial JJ cord-010092-uftc8inx 8010 28 services service NNS cord-010092-uftc8inx 8010 29 , , , cord-010092-uftc8inx 8010 30 factory factory NN cord-010092-uftc8inx 8010 31 workers worker NNS cord-010092-uftc8inx 8010 32 , , , cord-010092-uftc8inx 8010 33 retired retire VBN cord-010092-uftc8inx 8010 34 , , , cord-010092-uftc8inx 8010 35 unemployed unemployed JJ cord-010092-uftc8inx 8010 36 , , , cord-010092-uftc8inx 8010 37 or or CC cord-010092-uftc8inx 8010 38 self self NN cord-010092-uftc8inx 8010 39 - - HYPH cord-010092-uftc8inx 8010 40 employed employ VBN cord-010092-uftc8inx 8010 41 ) ) -RRB- cord-010092-uftc8inx 8010 42 were be VBD cord-010092-uftc8inx 8010 43 associated associate VBN cord-010092-uftc8inx 8010 44 with with IN cord-010092-uftc8inx 8010 45 positive positive JJ cord-010092-uftc8inx 8010 46 HIV HIV NNP cord-010092-uftc8inx 8010 47 confirmatory confirmatory JJ cord-010092-uftc8inx 8010 48 testing testing NN cord-010092-uftc8inx 8010 49 results result NNS cord-010092-uftc8inx 8010 50 . . . cord-010092-uftc8inx 8011 1 Summary Summary NNP cord-010092-uftc8inx 8011 2 / / SYM cord-010092-uftc8inx 8011 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 8011 4 : : : cord-010092-uftc8inx 8012 1 Although although IN cord-010092-uftc8inx 8012 2 HIV HIV NNP cord-010092-uftc8inx 8012 3 prevalence prevalence NN cord-010092-uftc8inx 8012 4 and and CC cord-010092-uftc8inx 8012 5 incidence incidence NN cord-010092-uftc8inx 8012 6 remain remain VBP cord-010092-uftc8inx 8012 7 low low JJ cord-010092-uftc8inx 8012 8 among among IN cord-010092-uftc8inx 8012 9 Chinese chinese JJ cord-010092-uftc8inx 8012 10 blood blood NN cord-010092-uftc8inx 8012 11 donors donor NNS cord-010092-uftc8inx 8012 12 , , , cord-010092-uftc8inx 8012 13 it -PRON- PRP cord-010092-uftc8inx 8012 14 is be VBZ cord-010092-uftc8inx 8012 15 important important JJ cord-010092-uftc8inx 8012 16 to to TO cord-010092-uftc8inx 8012 17 monitor monitor VB cord-010092-uftc8inx 8012 18 HIV HIV NNP cord-010092-uftc8inx 8012 19 epidemiology epidemiology NN cord-010092-uftc8inx 8012 20 in in IN cord-010092-uftc8inx 8012 21 blood blood NN cord-010092-uftc8inx 8012 22 donors donor NNS cord-010092-uftc8inx 8012 23 on on IN cord-010092-uftc8inx 8012 24 a a DT cord-010092-uftc8inx 8012 25 continuous continuous JJ cord-010092-uftc8inx 8012 26 basis basis NN cord-010092-uftc8inx 8012 27 , , , cord-010092-uftc8inx 8012 28 especially especially RB cord-010092-uftc8inx 8012 29 among among IN cord-010092-uftc8inx 8012 30 populations population NNS cord-010092-uftc8inx 8012 31 and and CC cord-010092-uftc8inx 8012 32 regions region NNS cord-010092-uftc8inx 8012 33 of of IN cord-010092-uftc8inx 8012 34 higher high JJR cord-010092-uftc8inx 8012 35 risk risk NN cord-010092-uftc8inx 8012 36 . . . cord-010092-uftc8inx 8013 1 Further further JJ cord-010092-uftc8inx 8013 2 donor donor NN cord-010092-uftc8inx 8013 3 screening screening NN cord-010092-uftc8inx 8013 4 and and CC cord-010092-uftc8inx 8013 5 education education NN cord-010092-uftc8inx 8013 6 strategies strategy NNS cord-010092-uftc8inx 8013 7 need need VBP cord-010092-uftc8inx 8013 8 to to TO cord-010092-uftc8inx 8013 9 be be VB cord-010092-uftc8inx 8013 10 developed develop VBN cord-010092-uftc8inx 8013 11 and and CC cord-010092-uftc8inx 8013 12 evaluated evaluate VBN cord-010092-uftc8inx 8013 13 to to TO cord-010092-uftc8inx 8013 14 reduce reduce VB cord-010092-uftc8inx 8013 15 these these DT cord-010092-uftc8inx 8013 16 risks risk NNS cord-010092-uftc8inx 8013 17 . . . cord-010092-uftc8inx 8014 1 The the DT cord-010092-uftc8inx 8014 2 IR IR NNP cord-010092-uftc8inx 8014 3 methods method NNS cord-010092-uftc8inx 8014 4 used use VBN cord-010092-uftc8inx 8014 5 in in IN cord-010092-uftc8inx 8014 6 this this DT cord-010092-uftc8inx 8014 7 study study NN cord-010092-uftc8inx 8014 8 for for IN cord-010092-uftc8inx 8014 9 first first JJ cord-010092-uftc8inx 8014 10 time time NN cord-010092-uftc8inx 8014 11 donors donor NNS cord-010092-uftc8inx 8014 12 as as RB cord-010092-uftc8inx 8014 13 well well RB cord-010092-uftc8inx 8014 14 as as IN cord-010092-uftc8inx 8014 15 repeat repeat NN cord-010092-uftc8inx 8014 16 donors donor NNS cord-010092-uftc8inx 8014 17 who who WP cord-010092-uftc8inx 8014 18 donate donate VBP cord-010092-uftc8inx 8014 19 very very RB cord-010092-uftc8inx 8014 20 infrequently infrequently RB cord-010092-uftc8inx 8014 21 is be VBZ cord-010092-uftc8inx 8014 22 readily readily RB cord-010092-uftc8inx 8014 23 applicable applicable JJ cord-010092-uftc8inx 8014 24 to to IN cord-010092-uftc8inx 8014 25 other other JJ cord-010092-uftc8inx 8014 26 countries country NNS cord-010092-uftc8inx 8014 27 who who WP cord-010092-uftc8inx 8014 28 have have VBP cord-010092-uftc8inx 8014 29 similar similar JJ cord-010092-uftc8inx 8014 30 donation donation NN cord-010092-uftc8inx 8014 31 patterns pattern NNS cord-010092-uftc8inx 8014 32 . . . cord-010092-uftc8inx 8015 1 Background background NN cord-010092-uftc8inx 8015 2 : : : cord-010092-uftc8inx 8016 1 In in IN cord-010092-uftc8inx 8016 2 Thailand Thailand NNP cord-010092-uftc8inx 8016 3 , , , cord-010092-uftc8inx 8016 4 the the DT cord-010092-uftc8inx 8016 5 National National NNP cord-010092-uftc8inx 8016 6 Blood Blood NNP cord-010092-uftc8inx 8016 7 Centre Centre NNP cord-010092-uftc8inx 8016 8 is be VBZ cord-010092-uftc8inx 8016 9 responsible responsible JJ cord-010092-uftc8inx 8016 10 for for IN cord-010092-uftc8inx 8016 11 blood blood NN cord-010092-uftc8inx 8016 12 donation donation NN cord-010092-uftc8inx 8016 13 service service NN cord-010092-uftc8inx 8016 14 which which WDT cord-010092-uftc8inx 8016 15 includes include VBZ cord-010092-uftc8inx 8016 16 follow follow NN cord-010092-uftc8inx 8016 17 - - HYPH cord-010092-uftc8inx 8016 18 up up NN cord-010092-uftc8inx 8016 19 and and CC cord-010092-uftc8inx 8016 20 blood blood NN cord-010092-uftc8inx 8016 21 donor donor NN cord-010092-uftc8inx 8016 22 counseling counseling NN cord-010092-uftc8inx 8016 23 in in IN cord-010092-uftc8inx 8016 24 order order NN cord-010092-uftc8inx 8016 25 to to TO cord-010092-uftc8inx 8016 26 indicate indicate VB cord-010092-uftc8inx 8016 27 the the DT cord-010092-uftc8inx 8016 28 infection infection NN cord-010092-uftc8inx 8016 29 status status NN cord-010092-uftc8inx 8016 30 , , , cord-010092-uftc8inx 8016 31 especially especially RB cord-010092-uftc8inx 8016 32 HIV HIV NNP cord-010092-uftc8inx 8016 33 - - HYPH cord-010092-uftc8inx 8016 34 positive positive JJ cord-010092-uftc8inx 8016 35 blood blood NN cord-010092-uftc8inx 8016 36 donors donor NNS cord-010092-uftc8inx 8016 37 . . . cord-010092-uftc8inx 8017 1 Currently currently RB cord-010092-uftc8inx 8017 2 , , , cord-010092-uftc8inx 8017 3 although although IN cord-010092-uftc8inx 8017 4 the the DT cord-010092-uftc8inx 8017 5 epidemic epidemic NN cord-010092-uftc8inx 8017 6 of of IN cord-010092-uftc8inx 8017 7 HIV HIV NNP cord-010092-uftc8inx 8017 8 infection infection NN cord-010092-uftc8inx 8017 9 in in IN cord-010092-uftc8inx 8017 10 Thailand Thailand NNP cord-010092-uftc8inx 8017 11 is be VBZ cord-010092-uftc8inx 8017 12 in in IN cord-010092-uftc8inx 8017 13 decline decline NN cord-010092-uftc8inx 8017 14 , , , cord-010092-uftc8inx 8017 15 the the DT cord-010092-uftc8inx 8017 16 HIV HIV NNP cord-010092-uftc8inx 8017 17 - - HYPH cord-010092-uftc8inx 8017 18 positive positive JJ cord-010092-uftc8inx 8017 19 cases case NNS cord-010092-uftc8inx 8017 20 still still RB cord-010092-uftc8inx 8017 21 have have VBP cord-010092-uftc8inx 8017 22 been be VBN cord-010092-uftc8inx 8017 23 found find VBN cord-010092-uftc8inx 8017 24 in in IN cord-010092-uftc8inx 8017 25 blood blood NN cord-010092-uftc8inx 8017 26 donors donor NNS cord-010092-uftc8inx 8017 27 screening screen VBG cord-010092-uftc8inx 8017 28 . . . cord-010092-uftc8inx 8018 1 Thus thus RB cord-010092-uftc8inx 8018 2 , , , cord-010092-uftc8inx 8018 3 monitoring monitor VBG cord-010092-uftc8inx 8018 4 of of IN cord-010092-uftc8inx 8018 5 HIV HIV NNP cord-010092-uftc8inx 8018 6 infection infection NN cord-010092-uftc8inx 8018 7 status status NN cord-010092-uftc8inx 8018 8 in in IN cord-010092-uftc8inx 8018 9 blood blood NN cord-010092-uftc8inx 8018 10 donors donor NNS cord-010092-uftc8inx 8018 11 and and CC cord-010092-uftc8inx 8018 12 post post JJ cord-010092-uftc8inx 8018 13 - - JJ cord-010092-uftc8inx 8018 14 blood blood JJ cord-010092-uftc8inx 8018 15 donor donor NN cord-010092-uftc8inx 8018 16 counseling counseling NN cord-010092-uftc8inx 8018 17 are be VBP cord-010092-uftc8inx 8018 18 important important JJ cord-010092-uftc8inx 8018 19 for for IN cord-010092-uftc8inx 8018 20 providing provide VBG cord-010092-uftc8inx 8018 21 the the DT cord-010092-uftc8inx 8018 22 HIV HIV NNP cord-010092-uftc8inx 8018 23 - - HYPH cord-010092-uftc8inx 8018 24 positive positive JJ cord-010092-uftc8inx 8018 25 infected infected JJ cord-010092-uftc8inx 8018 26 donors donor NNS cord-010092-uftc8inx 8018 27 lead lead VBP cord-010092-uftc8inx 8018 28 to to TO cord-010092-uftc8inx 8018 29 access access VB cord-010092-uftc8inx 8018 30 the the DT cord-010092-uftc8inx 8018 31 HIV HIV NNP cord-010092-uftc8inx 8018 32 treatment treatment NN cord-010092-uftc8inx 8018 33 immediately immediately RB cord-010092-uftc8inx 8018 34 . . . cord-010092-uftc8inx 8019 1 Aims aim VBZ cord-010092-uftc8inx 8019 2 : : : cord-010092-uftc8inx 8020 1 To to TO cord-010092-uftc8inx 8020 2 study study VB cord-010092-uftc8inx 8020 3 the the DT cord-010092-uftc8inx 8020 4 HIV HIV NNP cord-010092-uftc8inx 8020 5 follow follow NN cord-010092-uftc8inx 8020 6 - - HYPH cord-010092-uftc8inx 8020 7 up up NN cord-010092-uftc8inx 8020 8 cases case NNS cord-010092-uftc8inx 8020 9 on on IN cord-010092-uftc8inx 8020 10 serological serological JJ cord-010092-uftc8inx 8020 11 testing testing NN cord-010092-uftc8inx 8020 12 over over IN cord-010092-uftc8inx 8020 13 10 10 CD cord-010092-uftc8inx 8020 14 years year NNS cord-010092-uftc8inx 8020 15 for for IN cord-010092-uftc8inx 8020 16 assessment assessment NN cord-010092-uftc8inx 8020 17 of of IN cord-010092-uftc8inx 8020 18 the the DT cord-010092-uftc8inx 8020 19 HIV HIV NNP cord-010092-uftc8inx 8020 20 infection infection NN cord-010092-uftc8inx 8020 21 in in IN cord-010092-uftc8inx 8020 22 Thai Thai NNP cord-010092-uftc8inx 8020 23 blood blood NN cord-010092-uftc8inx 8020 24 donors donor NNS cord-010092-uftc8inx 8020 25 . . . cord-010092-uftc8inx 8021 1 The the DT cord-010092-uftc8inx 8021 2 retrospective retrospective JJ cord-010092-uftc8inx 8021 3 analysis analysis NN cord-010092-uftc8inx 8021 4 of of IN cord-010092-uftc8inx 8021 5 HIV HIV NNP cord-010092-uftc8inx 8021 6 follow follow NN cord-010092-uftc8inx 8021 7 - - HYPH cord-010092-uftc8inx 8021 8 up up NN cord-010092-uftc8inx 8021 9 cases case NNS cord-010092-uftc8inx 8021 10 on on IN cord-010092-uftc8inx 8021 11 serological serological JJ cord-010092-uftc8inx 8021 12 testing testing NN cord-010092-uftc8inx 8021 13 ( ( -LRB- cord-010092-uftc8inx 8021 14 CMIA CMIA NNP cord-010092-uftc8inx 8021 15 , , , cord-010092-uftc8inx 8021 16 ICS ICS NNP cord-010092-uftc8inx 8021 17 and and CC cord-010092-uftc8inx 8021 18 Western western JJ cord-010092-uftc8inx 8021 19 blot blot NN cord-010092-uftc8inx 8021 20 ) ) -RRB- cord-010092-uftc8inx 8021 21 was be VBD cord-010092-uftc8inx 8021 22 conducted conduct VBN cord-010092-uftc8inx 8021 23 during during IN cord-010092-uftc8inx 8021 24 2009 2009 CD cord-010092-uftc8inx 8021 25 to to IN cord-010092-uftc8inx 8021 26 2018 2018 CD cord-010092-uftc8inx 8021 27 at at IN cord-010092-uftc8inx 8021 28 Thai Thai NNP cord-010092-uftc8inx 8021 29 National National NNP cord-010092-uftc8inx 8021 30 Blood Blood NNP cord-010092-uftc8inx 8021 31 Centre Centre NNP cord-010092-uftc8inx 8021 32 . . . cord-010092-uftc8inx 8022 1 Results result NNS cord-010092-uftc8inx 8022 2 : : : cord-010092-uftc8inx 8023 1 A a DT cord-010092-uftc8inx 8023 2 total total NN cord-010092-uftc8inx 8023 3 of of IN cord-010092-uftc8inx 8023 4 6,408,024 6,408,024 CD cord-010092-uftc8inx 8023 5 voluntary voluntary JJ cord-010092-uftc8inx 8023 6 blood blood NN cord-010092-uftc8inx 8023 7 donations donation NNS cord-010092-uftc8inx 8023 8 over over IN cord-010092-uftc8inx 8023 9 10 10 CD cord-010092-uftc8inx 8023 10 years year NNS cord-010092-uftc8inx 8023 11 , , , cord-010092-uftc8inx 8023 12 the the DT cord-010092-uftc8inx 8023 13 repeated repeat VBN cord-010092-uftc8inx 8023 14 reactive reactive JJ cord-010092-uftc8inx 8023 15 results result NNS cord-010092-uftc8inx 8023 16 on on IN cord-010092-uftc8inx 8023 17 HIV HIV NNP cord-010092-uftc8inx 8023 18 serological serological JJ cord-010092-uftc8inx 8023 19 screening screening NN cord-010092-uftc8inx 8023 20 were be VBD cord-010092-uftc8inx 8023 21 5,978 5,978 CD cord-010092-uftc8inx 8023 22 ( ( -LRB- cord-010092-uftc8inx 8023 23 0.093 0.093 CD cord-010092-uftc8inx 8023 24 % % NN cord-010092-uftc8inx 8023 25 ) ) -RRB- cord-010092-uftc8inx 8023 26 cases case NNS cord-010092-uftc8inx 8023 27 and and CC cord-010092-uftc8inx 8023 28 only only RB cord-010092-uftc8inx 8023 29 half half NN cord-010092-uftc8inx 8023 30 of of IN cord-010092-uftc8inx 8023 31 these these DT cord-010092-uftc8inx 8023 32 HIV HIV NNP cord-010092-uftc8inx 8023 33 reactive reactive JJ cord-010092-uftc8inx 8023 34 donors donor NNS cord-010092-uftc8inx 8023 35 returned return VBD cord-010092-uftc8inx 8023 36 to to TO cord-010092-uftc8inx 8023 37 follow follow VB cord-010092-uftc8inx 8023 38 - - HYPH cord-010092-uftc8inx 8023 39 up up NN cord-010092-uftc8inx 8023 40 testing testing NN cord-010092-uftc8inx 8023 41 for for IN cord-010092-uftc8inx 8023 42 ascertaining ascertain VBG cord-010092-uftc8inx 8023 43 their -PRON- PRP$ cord-010092-uftc8inx 8023 44 HIV HIV NNP cord-010092-uftc8inx 8023 45 status status NN cord-010092-uftc8inx 8023 46 . . . cord-010092-uftc8inx 8024 1 For for IN cord-010092-uftc8inx 8024 2 HIV HIV NNP cord-010092-uftc8inx 8024 3 follow follow NN cord-010092-uftc8inx 8024 4 - - HYPH cord-010092-uftc8inx 8024 5 up up NN cord-010092-uftc8inx 8024 6 process process NN cord-010092-uftc8inx 8024 7 , , , cord-010092-uftc8inx 8024 8 the the DT cord-010092-uftc8inx 8024 9 HIV HIV NNP cord-010092-uftc8inx 8024 10 reactive reactive JJ cord-010092-uftc8inx 8024 11 screening screening NN cord-010092-uftc8inx 8024 12 donors donor NNS cord-010092-uftc8inx 8024 13 must must MD cord-010092-uftc8inx 8024 14 be be VB cord-010092-uftc8inx 8024 15 followed follow VBN cord-010092-uftc8inx 8024 16 for for IN cord-010092-uftc8inx 8024 17 6 6 CD cord-010092-uftc8inx 8024 18 months month NNS cord-010092-uftc8inx 8024 19 and and CC cord-010092-uftc8inx 8024 20 tested test VBN cord-010092-uftc8inx 8024 21 by by IN cord-010092-uftc8inx 8024 22 using use VBG cord-010092-uftc8inx 8024 23 the the DT cord-010092-uftc8inx 8024 24 different different JJ cord-010092-uftc8inx 8024 25 three three CD cord-010092-uftc8inx 8024 26 principles principle NNS cord-010092-uftc8inx 8024 27 of of IN cord-010092-uftc8inx 8024 28 HIV HIV NNP cord-010092-uftc8inx 8024 29 serological serological JJ cord-010092-uftc8inx 8024 30 testing testing NN cord-010092-uftc8inx 8024 31 . . . cord-010092-uftc8inx 8025 1 A a DT cord-010092-uftc8inx 8025 2 total total NN cord-010092-uftc8inx 8025 3 of of IN cord-010092-uftc8inx 8025 4 5,978 5,978 CD cord-010092-uftc8inx 8025 5 HIV HIV NNP cord-010092-uftc8inx 8025 6 reactive reactive JJ cord-010092-uftc8inx 8025 7 results result NNS cord-010092-uftc8inx 8025 8 were be VBD cord-010092-uftc8inx 8025 9 separated separate VBN cord-010092-uftc8inx 8025 10 to to IN cord-010092-uftc8inx 8025 11 three three CD cord-010092-uftc8inx 8025 12 patterns pattern NNS cord-010092-uftc8inx 8025 13 including include VBG cord-010092-uftc8inx 8025 14 HIV HIV NNP cord-010092-uftc8inx 8025 15 positive positive JJ cord-010092-uftc8inx 8025 16 results result NNS cord-010092-uftc8inx 8025 17 , , , cord-010092-uftc8inx 8025 18 inconclusive inconclusive JJ cord-010092-uftc8inx 8025 19 results result NNS cord-010092-uftc8inx 8025 20 and and CC cord-010092-uftc8inx 8025 21 negative negative JJ cord-010092-uftc8inx 8025 22 results result NNS cord-010092-uftc8inx 8025 23 which which WDT cord-010092-uftc8inx 8025 24 the the DT cord-010092-uftc8inx 8025 25 number number NN cord-010092-uftc8inx 8025 26 of of IN cord-010092-uftc8inx 8025 27 each each DT cord-010092-uftc8inx 8025 28 group group NN cord-010092-uftc8inx 8025 29 was be VBD cord-010092-uftc8inx 8025 30 1,130 1,130 CD cord-010092-uftc8inx 8025 31 ( ( -LRB- cord-010092-uftc8inx 8025 32 35.7 35.7 CD cord-010092-uftc8inx 8025 33 % % NN cord-010092-uftc8inx 8025 34 ) ) -RRB- cord-010092-uftc8inx 8025 35 cases case NNS cord-010092-uftc8inx 8025 36 , , , cord-010092-uftc8inx 8025 37 742 742 CD cord-010092-uftc8inx 8025 38 ( ( -LRB- cord-010092-uftc8inx 8025 39 23.5 23.5 CD cord-010092-uftc8inx 8025 40 % % NN cord-010092-uftc8inx 8025 41 ) ) -RRB- cord-010092-uftc8inx 8025 42 cases case NNS cord-010092-uftc8inx 8025 43 and and CC cord-010092-uftc8inx 8025 44 1,292 1,292 CD cord-010092-uftc8inx 8025 45 ( ( -LRB- cord-010092-uftc8inx 8025 46 40.8 40.8 CD cord-010092-uftc8inx 8025 47 % % NN cord-010092-uftc8inx 8025 48 ) ) -RRB- cord-010092-uftc8inx 8025 49 cases case NNS cord-010092-uftc8inx 8025 50 respectively respectively RB cord-010092-uftc8inx 8025 51 . . . cord-010092-uftc8inx 8026 1 Out out IN cord-010092-uftc8inx 8026 2 of of IN cord-010092-uftc8inx 8026 3 1,130 1,130 CD cord-010092-uftc8inx 8026 4 HIV HIV NNP cord-010092-uftc8inx 8026 5 positive positive JJ cord-010092-uftc8inx 8026 6 results result NNS cord-010092-uftc8inx 8026 7 , , , cord-010092-uftc8inx 8026 8 we -PRON- PRP cord-010092-uftc8inx 8026 9 found find VBD cord-010092-uftc8inx 8026 10 that that IN cord-010092-uftc8inx 8026 11 1,105 1,105 CD cord-010092-uftc8inx 8026 12 ( ( -LRB- cord-010092-uftc8inx 8026 13 97.8 97.8 CD cord-010092-uftc8inx 8026 14 % % NN cord-010092-uftc8inx 8026 15 ) ) -RRB- cord-010092-uftc8inx 8026 16 cases case NNS cord-010092-uftc8inx 8026 17 were be VBD cord-010092-uftc8inx 8026 18 positive positive JJ cord-010092-uftc8inx 8026 19 with with IN cord-010092-uftc8inx 8026 20 all all DT cord-010092-uftc8inx 8026 21 HIV HIV NNP cord-010092-uftc8inx 8026 22 serological serological JJ cord-010092-uftc8inx 8026 23 testing testing NN cord-010092-uftc8inx 8026 24 for for IN cord-010092-uftc8inx 8026 25 the the DT cord-010092-uftc8inx 8026 26 first first JJ cord-010092-uftc8inx 8026 27 - - HYPH cord-010092-uftc8inx 8026 28 time time NN cord-010092-uftc8inx 8026 29 follow follow NN cord-010092-uftc8inx 8026 30 - - HYPH cord-010092-uftc8inx 8026 31 up up NN cord-010092-uftc8inx 8026 32 and and CC cord-010092-uftc8inx 8026 33 25 25 CD cord-010092-uftc8inx 8026 34 ( ( -LRB- cord-010092-uftc8inx 8026 35 2.2 2.2 CD cord-010092-uftc8inx 8026 36 % % NN cord-010092-uftc8inx 8026 37 ) ) -RRB- cord-010092-uftc8inx 8026 38 cases case NNS cord-010092-uftc8inx 8026 39 were be VBD cord-010092-uftc8inx 8026 40 tested test VBN cord-010092-uftc8inx 8026 41 and and CC cord-010092-uftc8inx 8026 42 become become VBN cord-010092-uftc8inx 8026 43 to to IN cord-010092-uftc8inx 8026 44 positive positive JJ cord-010092-uftc8inx 8026 45 results result NNS cord-010092-uftc8inx 8026 46 after after IN cord-010092-uftc8inx 8026 47 follow follow NN cord-010092-uftc8inx 8026 48 - - HYPH cord-010092-uftc8inx 8026 49 up up NN cord-010092-uftc8inx 8026 50 more more JJR cord-010092-uftc8inx 8026 51 than than IN cord-010092-uftc8inx 8026 52 one one CD cord-010092-uftc8inx 8026 53 time time NN cord-010092-uftc8inx 8026 54 . . . cord-010092-uftc8inx 8027 1 In in IN cord-010092-uftc8inx 8027 2 742 742 CD cord-010092-uftc8inx 8027 3 cases case NNS cord-010092-uftc8inx 8027 4 of of IN cord-010092-uftc8inx 8027 5 inconclusive inconclusive JJ cord-010092-uftc8inx 8027 6 results result NNS cord-010092-uftc8inx 8027 7 , , , cord-010092-uftc8inx 8027 8 539 539 CD cord-010092-uftc8inx 8027 9 ( ( -LRB- cord-010092-uftc8inx 8027 10 72.6 72.6 CD cord-010092-uftc8inx 8027 11 % % NN cord-010092-uftc8inx 8027 12 ) ) -RRB- cord-010092-uftc8inx 8027 13 cases case NNS cord-010092-uftc8inx 8027 14 were be VBD cord-010092-uftc8inx 8027 15 reactive reactive JJ cord-010092-uftc8inx 8027 16 only only RB cord-010092-uftc8inx 8027 17 1 1 CD cord-010092-uftc8inx 8027 18 or or CC cord-010092-uftc8inx 8027 19 2 2 CD cord-010092-uftc8inx 8027 20 testing(s testing(s NN cord-010092-uftc8inx 8027 21 ) ) -RRB- cord-010092-uftc8inx 8027 22 which which WDT cord-010092-uftc8inx 8027 23 these these DT cord-010092-uftc8inx 8027 24 donors donor NNS cord-010092-uftc8inx 8027 25 did do VBD cord-010092-uftc8inx 8027 26 not not RB cord-010092-uftc8inx 8027 27 return return VB cord-010092-uftc8inx 8027 28 to to TO cord-010092-uftc8inx 8027 29 confirm confirm VB cord-010092-uftc8inx 8027 30 again again RB cord-010092-uftc8inx 8027 31 leading lead VBG cord-010092-uftc8inx 8027 32 to to IN cord-010092-uftc8inx 8027 33 temporarily temporarily RB cord-010092-uftc8inx 8027 34 deferred defer VBN cord-010092-uftc8inx 8027 35 donors donor NNS cord-010092-uftc8inx 8027 36 in in IN cord-010092-uftc8inx 8027 37 blood blood NN cord-010092-uftc8inx 8027 38 donor donor NN cord-010092-uftc8inx 8027 39 system system NN cord-010092-uftc8inx 8027 40 . . . cord-010092-uftc8inx 8028 1 In in IN cord-010092-uftc8inx 8028 2 addition addition NN cord-010092-uftc8inx 8028 3 , , , cord-010092-uftc8inx 8028 4 203 203 CD cord-010092-uftc8inx 8028 5 ( ( -LRB- cord-010092-uftc8inx 8028 6 27.4 27.4 CD cord-010092-uftc8inx 8028 7 % % NN cord-010092-uftc8inx 8028 8 ) ) -RRB- cord-010092-uftc8inx 8028 9 cases case NNS cord-010092-uftc8inx 8028 10 of of IN cord-010092-uftc8inx 8028 11 inconclusive inconclusive JJ cord-010092-uftc8inx 8028 12 results result NNS cord-010092-uftc8inx 8028 13 could could MD cord-010092-uftc8inx 8028 14 not not RB cord-010092-uftc8inx 8028 15 conclude conclude VB cord-010092-uftc8inx 8028 16 the the DT cord-010092-uftc8inx 8028 17 HIV HIV NNP cord-010092-uftc8inx 8028 18 result result NN cord-010092-uftc8inx 8028 19 although although IN cord-010092-uftc8inx 8028 20 they -PRON- PRP cord-010092-uftc8inx 8028 21 were be VBD cord-010092-uftc8inx 8028 22 repeated repeat VBN cord-010092-uftc8inx 8028 23 several several JJ cord-010092-uftc8inx 8028 24 times time NNS cord-010092-uftc8inx 8028 25 . . . cord-010092-uftc8inx 8029 1 For for IN cord-010092-uftc8inx 8029 2 the the DT cord-010092-uftc8inx 8029 3 last last JJ cord-010092-uftc8inx 8029 4 pattern pattern NN cord-010092-uftc8inx 8029 5 , , , cord-010092-uftc8inx 8029 6 1,292 1,292 CD cord-010092-uftc8inx 8029 7 negative negative JJ cord-010092-uftc8inx 8029 8 results result NNS cord-010092-uftc8inx 8029 9 cases case NNS cord-010092-uftc8inx 8029 10 showed show VBD cord-010092-uftc8inx 8029 11 762 762 CD cord-010092-uftc8inx 8029 12 ( ( -LRB- cord-010092-uftc8inx 8030 1 59.0 59.0 CD cord-010092-uftc8inx 8030 2 % % NN cord-010092-uftc8inx 8030 3 ) ) -RRB- cord-010092-uftc8inx 8030 4 cases case NNS cord-010092-uftc8inx 8030 5 were be VBD cord-010092-uftc8inx 8030 6 negative negative JJ cord-010092-uftc8inx 8030 7 results result NNS cord-010092-uftc8inx 8030 8 after after IN cord-010092-uftc8inx 8030 9 follow follow NN cord-010092-uftc8inx 8030 10 - - HYPH cord-010092-uftc8inx 8030 11 up up NN cord-010092-uftc8inx 8030 12 over over IN cord-010092-uftc8inx 8030 13 6 6 CD cord-010092-uftc8inx 8030 14 months month NNS cord-010092-uftc8inx 8030 15 while while IN cord-010092-uftc8inx 8030 16 530 530 CD cord-010092-uftc8inx 8030 17 ( ( -LRB- cord-010092-uftc8inx 8030 18 41.0 41.0 CD cord-010092-uftc8inx 8030 19 % % NN cord-010092-uftc8inx 8030 20 ) ) -RRB- cord-010092-uftc8inx 8030 21 cases case NNS cord-010092-uftc8inx 8030 22 were be VBD cord-010092-uftc8inx 8030 23 inconclusive inconclusive JJ cord-010092-uftc8inx 8030 24 results result NNS cord-010092-uftc8inx 8030 25 before before IN cord-010092-uftc8inx 8030 26 changing change VBG cord-010092-uftc8inx 8030 27 to to IN cord-010092-uftc8inx 8030 28 negative negative JJ cord-010092-uftc8inx 8030 29 results result NNS cord-010092-uftc8inx 8030 30 which which WDT cord-010092-uftc8inx 8030 31 almost almost RB cord-010092-uftc8inx 8030 32 cases case NNS cord-010092-uftc8inx 8030 33 of of IN cord-010092-uftc8inx 8030 34 this this DT cord-010092-uftc8inx 8030 35 group group NN cord-010092-uftc8inx 8030 36 were be VBD cord-010092-uftc8inx 8030 37 reentry reentry NN cord-010092-uftc8inx 8030 38 as as IN cord-010092-uftc8inx 8030 39 blood blood NN cord-010092-uftc8inx 8030 40 donor donor NN cord-010092-uftc8inx 8030 41 after after IN cord-010092-uftc8inx 8030 42 deferral deferral NN cord-010092-uftc8inx 8030 43 period period NN cord-010092-uftc8inx 8030 44 is be VBZ cord-010092-uftc8inx 8030 45 over over RB cord-010092-uftc8inx 8030 46 . . . cord-010092-uftc8inx 8031 1 Summary Summary NNP cord-010092-uftc8inx 8031 2 / / SYM cord-010092-uftc8inx 8031 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 8031 4 : : : cord-010092-uftc8inx 8032 1 The the DT cord-010092-uftc8inx 8032 2 number number NN cord-010092-uftc8inx 8032 3 of of IN cord-010092-uftc8inx 8032 4 repeated repeat VBN cord-010092-uftc8inx 8032 5 reactive reactive JJ cord-010092-uftc8inx 8032 6 results result NNS cord-010092-uftc8inx 8032 7 on on IN cord-010092-uftc8inx 8032 8 HIV HIV NNP cord-010092-uftc8inx 8032 9 screening screening NN cord-010092-uftc8inx 8032 10 was be VBD cord-010092-uftc8inx 8032 11 constant constant JJ cord-010092-uftc8inx 8032 12 over over IN cord-010092-uftc8inx 8032 13 10 10 CD cord-010092-uftc8inx 8032 14 years year NNS cord-010092-uftc8inx 8032 15 of of IN cord-010092-uftc8inx 8032 16 which which WDT cord-010092-uftc8inx 8032 17 returned return VBD cord-010092-uftc8inx 8032 18 to to IN cord-010092-uftc8inx 8032 19 follow follow VB cord-010092-uftc8inx 8032 20 - - HYPH cord-010092-uftc8inx 8032 21 up up NN cord-010092-uftc8inx 8032 22 only only RB cord-010092-uftc8inx 8032 23 half half NN cord-010092-uftc8inx 8032 24 of of IN cord-010092-uftc8inx 8032 25 HIV HIV NNP cord-010092-uftc8inx 8032 26 reactive reactive JJ cord-010092-uftc8inx 8032 27 donors donor NNS cord-010092-uftc8inx 8032 28 leading lead VBG cord-010092-uftc8inx 8032 29 to to IN cord-010092-uftc8inx 8032 30 accumulation accumulation NN cord-010092-uftc8inx 8032 31 of of IN cord-010092-uftc8inx 8032 32 temporarily temporarily RB cord-010092-uftc8inx 8032 33 deferred defer VBN cord-010092-uftc8inx 8032 34 donors donor NNS cord-010092-uftc8inx 8032 35 in in IN cord-010092-uftc8inx 8032 36 blood blood NN cord-010092-uftc8inx 8032 37 donation donation NN cord-010092-uftc8inx 8032 38 system system NN cord-010092-uftc8inx 8032 39 . . . cord-010092-uftc8inx 8033 1 HIV HIV NNP cord-010092-uftc8inx 8033 2 follow follow VB cord-010092-uftc8inx 8033 3 - - HYPH cord-010092-uftc8inx 8033 4 up up RP cord-010092-uftc8inx 8033 5 positive positive JJ cord-010092-uftc8inx 8033 6 cases case NNS cord-010092-uftc8inx 8033 7 were be VBD cord-010092-uftc8inx 8033 8 informed inform VBN cord-010092-uftc8inx 8033 9 and and CC cord-010092-uftc8inx 8033 10 counseled counsel VBN cord-010092-uftc8inx 8033 11 immediately immediately RB cord-010092-uftc8inx 8033 12 then then RB cord-010092-uftc8inx 8033 13 referring refer VBG cord-010092-uftc8inx 8033 14 to to IN cord-010092-uftc8inx 8033 15 anonymous anonymous JJ cord-010092-uftc8inx 8033 16 clinic clinic NN cord-010092-uftc8inx 8033 17 for for IN cord-010092-uftc8inx 8033 18 treatment treatment NN cord-010092-uftc8inx 8033 19 . . . cord-010092-uftc8inx 8034 1 The the DT cord-010092-uftc8inx 8034 2 problem problem NN cord-010092-uftc8inx 8034 3 and and CC cord-010092-uftc8inx 8034 4 challenges challenge NNS cord-010092-uftc8inx 8034 5 of of IN cord-010092-uftc8inx 8034 6 HIV HIV NNP cord-010092-uftc8inx 8034 7 follow follow NN cord-010092-uftc8inx 8034 8 - - HYPH cord-010092-uftc8inx 8034 9 up up NN cord-010092-uftc8inx 8034 10 were be VBD cord-010092-uftc8inx 8034 11 inconclusive inconclusive JJ cord-010092-uftc8inx 8034 12 results result NNS cord-010092-uftc8inx 8034 13 that that WDT cord-010092-uftc8inx 8034 14 were be VBD cord-010092-uftc8inx 8034 15 unclear unclear JJ cord-010092-uftc8inx 8034 16 and and CC cord-010092-uftc8inx 8034 17 some some DT cord-010092-uftc8inx 8034 18 of of IN cord-010092-uftc8inx 8034 19 these these DT cord-010092-uftc8inx 8034 20 did do VBD cord-010092-uftc8inx 8034 21 not not RB cord-010092-uftc8inx 8034 22 return return VB cord-010092-uftc8inx 8034 23 to to TO cord-010092-uftc8inx 8034 24 retest retest VB cord-010092-uftc8inx 8034 25 lead lead NN cord-010092-uftc8inx 8034 26 to to IN cord-010092-uftc8inx 8034 27 loss loss NN cord-010092-uftc8inx 8034 28 of of IN cord-010092-uftc8inx 8034 29 re re NN cord-010092-uftc8inx 8034 30 - - NN cord-010092-uftc8inx 8034 31 entry entry JJ cord-010092-uftc8inx 8034 32 donor donor NN cord-010092-uftc8inx 8034 33 who who WP cord-010092-uftc8inx 8034 34 might may MD cord-010092-uftc8inx 8034 35 be be VB cord-010092-uftc8inx 8034 36 changed change VBN cord-010092-uftc8inx 8034 37 to to IN cord-010092-uftc8inx 8034 38 negative negative JJ cord-010092-uftc8inx 8034 39 result result NN cord-010092-uftc8inx 8034 40 afterward afterward RB cord-010092-uftc8inx 8034 41 . . . cord-010092-uftc8inx 8035 1 Hence hence RB cord-010092-uftc8inx 8035 2 , , , cord-010092-uftc8inx 8035 3 the the DT cord-010092-uftc8inx 8035 4 effective effective JJ cord-010092-uftc8inx 8035 5 counseling counseling NN cord-010092-uftc8inx 8035 6 and and CC cord-010092-uftc8inx 8035 7 follow follow NN cord-010092-uftc8inx 8035 8 - - HYPH cord-010092-uftc8inx 8035 9 up up NN cord-010092-uftc8inx 8035 10 system system NN cord-010092-uftc8inx 8035 11 need need VBP cord-010092-uftc8inx 8035 12 to to TO cord-010092-uftc8inx 8035 13 be be VB cord-010092-uftc8inx 8035 14 taken take VBN cord-010092-uftc8inx 8035 15 urgently urgently RB cord-010092-uftc8inx 8035 16 to to TO cord-010092-uftc8inx 8035 17 encourage encourage VB cord-010092-uftc8inx 8035 18 the the DT cord-010092-uftc8inx 8035 19 temporarily temporarily RB cord-010092-uftc8inx 8035 20 deferral deferral NN cord-010092-uftc8inx 8035 21 donors donor NNS cord-010092-uftc8inx 8035 22 returned return VBD cord-010092-uftc8inx 8035 23 to to TO cord-010092-uftc8inx 8035 24 retest retest VB cord-010092-uftc8inx 8035 25 for for IN cord-010092-uftc8inx 8035 26 reducing reduce VBG cord-010092-uftc8inx 8035 27 stigma stigma NN cord-010092-uftc8inx 8035 28 of of IN cord-010092-uftc8inx 8035 29 deferred deferred JJ cord-010092-uftc8inx 8035 30 donors donor NNS cord-010092-uftc8inx 8035 31 in in IN cord-010092-uftc8inx 8035 32 HIV HIV NNP cord-010092-uftc8inx 8035 33 follow follow NN cord-010092-uftc8inx 8035 34 - - HYPH cord-010092-uftc8inx 8035 35 up up NN cord-010092-uftc8inx 8035 36 cases case NNS cord-010092-uftc8inx 8035 37 . . . cord-010092-uftc8inx 8035 38 . . . cord-010092-uftc8inx 8036 1 We -PRON- PRP cord-010092-uftc8inx 8036 2 only only RB cord-010092-uftc8inx 8036 3 analyzed analyze VBD cord-010092-uftc8inx 8036 4 the the DT cord-010092-uftc8inx 8036 5 information information NN cord-010092-uftc8inx 8036 6 that that WDT cord-010092-uftc8inx 8036 7 had have VBD cord-010092-uftc8inx 8036 8 non non JJ cord-010092-uftc8inx 8036 9 - - JJ cord-010092-uftc8inx 8036 10 reactive reactive JJ cord-010092-uftc8inx 8036 11 results result NNS cord-010092-uftc8inx 8036 12 for for IN cord-010092-uftc8inx 8036 13 infectious infectious JJ cord-010092-uftc8inx 8036 14 markers marker NNS cord-010092-uftc8inx 8036 15 reported report VBN cord-010092-uftc8inx 8036 16 by by IN cord-010092-uftc8inx 8036 17 blood blood NN cord-010092-uftc8inx 8036 18 banks bank NNS cord-010092-uftc8inx 8036 19 to to IN cord-010092-uftc8inx 8036 20 SIHEVI SIHEVI NNP cord-010092-uftc8inx 8036 21 - - HYPH cord-010092-uftc8inx 8036 22 INS INS NNP cord-010092-uftc8inx 8036 23 © © NN cord-010092-uftc8inx 8036 24 , , , cord-010092-uftc8inx 8036 25 because because IN cord-010092-uftc8inx 8036 26 they -PRON- PRP cord-010092-uftc8inx 8036 27 represent represent VBP cord-010092-uftc8inx 8036 28 a a DT cord-010092-uftc8inx 8036 29 risk risk NN cord-010092-uftc8inx 8036 30 for for IN cord-010092-uftc8inx 8036 31 blood blood NN cord-010092-uftc8inx 8036 32 recipients recipient NNS cord-010092-uftc8inx 8036 33 . . . cord-010092-uftc8inx 8037 1 Results result NNS cord-010092-uftc8inx 8037 2 : : : cord-010092-uftc8inx 8037 3 When when WRB cord-010092-uftc8inx 8037 4 loading load VBG cord-010092-uftc8inx 8037 5 the the DT cord-010092-uftc8inx 8037 6 information information NN cord-010092-uftc8inx 8037 7 of of IN cord-010092-uftc8inx 8037 8 SIVIGILA SIVIGILA NNP cord-010092-uftc8inx 8037 9 in in IN cord-010092-uftc8inx 8037 10 SIHEVI SIHEVI NNP cord-010092-uftc8inx 8037 11 - - HYPH cord-010092-uftc8inx 8037 12 INS INS NNP cord-010092-uftc8inx 8037 13 © © NN cord-010092-uftc8inx 8037 14 , , , cord-010092-uftc8inx 8037 15 241 241 CD cord-010092-uftc8inx 8037 16 donors donor NNS cord-010092-uftc8inx 8037 17 were be VBD cord-010092-uftc8inx 8037 18 found find VBN cord-010092-uftc8inx 8037 19 ( ( -LRB- cord-010092-uftc8inx 8037 20 80 80 CD cord-010092-uftc8inx 8037 21 % % NN cord-010092-uftc8inx 8037 22 men man NNS cord-010092-uftc8inx 8037 23 ) ) -RRB- cord-010092-uftc8inx 8038 1 ; ; : cord-010092-uftc8inx 8038 2 of of IN cord-010092-uftc8inx 8038 3 these these DT cord-010092-uftc8inx 8038 4 people people NNS cord-010092-uftc8inx 8038 5 256 256 CD cord-010092-uftc8inx 8038 6 donations donation NNS cord-010092-uftc8inx 8038 7 were be VBD cord-010092-uftc8inx 8038 8 obtained obtain VBN cord-010092-uftc8inx 8038 9 ( ( -LRB- cord-010092-uftc8inx 8038 10 97 97 CD cord-010092-uftc8inx 8038 11 % % NN cord-010092-uftc8inx 8038 12 whole whole JJ cord-010092-uftc8inx 8038 13 blood blood NN cord-010092-uftc8inx 8038 14 ) ) -RRB- cord-010092-uftc8inx 8038 15 . . . cord-010092-uftc8inx 8039 1 166 166 CD cord-010092-uftc8inx 8039 2 donors donor NNS cord-010092-uftc8inx 8039 3 ( ( -LRB- cord-010092-uftc8inx 8039 4 69 69 CD cord-010092-uftc8inx 8039 5 % % NN cord-010092-uftc8inx 8039 6 ) ) -RRB- cord-010092-uftc8inx 8039 7 had have VBD cord-010092-uftc8inx 8039 8 a a DT cord-010092-uftc8inx 8039 9 reactive reactive JJ cord-010092-uftc8inx 8039 10 result result NN cord-010092-uftc8inx 8039 11 for for IN cord-010092-uftc8inx 8039 12 HIV HIV NNP cord-010092-uftc8inx 8039 13 being be VBG cord-010092-uftc8inx 8039 14 subsequently subsequently RB cord-010092-uftc8inx 8039 15 reported report VBN cord-010092-uftc8inx 8039 16 in in IN cord-010092-uftc8inx 8039 17 SIVIGILA SIVIGILA NNP cord-010092-uftc8inx 8039 18 . . . cord-010092-uftc8inx 8040 1 In in IN cord-010092-uftc8inx 8040 2 addition addition NN cord-010092-uftc8inx 8040 3 , , , cord-010092-uftc8inx 8040 4 five five CD cord-010092-uftc8inx 8040 5 of of IN cord-010092-uftc8inx 8040 6 them -PRON- PRP cord-010092-uftc8inx 8040 7 were be VBD cord-010092-uftc8inx 8040 8 reactive reactive JJ cord-010092-uftc8inx 8040 9 simultaneously simultaneously RB cord-010092-uftc8inx 8040 10 for for IN cord-010092-uftc8inx 8040 11 HBV HBV NNP cord-010092-uftc8inx 8040 12 in in IN cord-010092-uftc8inx 8040 13 blood blood NN cord-010092-uftc8inx 8040 14 banks bank NNS cord-010092-uftc8inx 8040 15 and and CC cord-010092-uftc8inx 8040 16 took take VBD cord-010092-uftc8inx 8040 17 on on RP cord-010092-uftc8inx 8040 18 average average JJ cord-010092-uftc8inx 8040 19 174 174 CD cord-010092-uftc8inx 8040 20 AE AE NNP cord-010092-uftc8inx 8040 21 83 83 CD cord-010092-uftc8inx 8040 22 days day NNS cord-010092-uftc8inx 8040 23 to to TO cord-010092-uftc8inx 8040 24 be be VB cord-010092-uftc8inx 8040 25 reported report VBN cord-010092-uftc8inx 8040 26 in in IN cord-010092-uftc8inx 8040 27 SIVIGILA SIVIGILA NNP cord-010092-uftc8inx 8040 28 . . . cord-010092-uftc8inx 8041 1 25 25 CD cord-010092-uftc8inx 8041 2 donors donor NNS cord-010092-uftc8inx 8041 3 ( ( -LRB- cord-010092-uftc8inx 8041 4 10.4 10.4 CD cord-010092-uftc8inx 8041 5 % % NN cord-010092-uftc8inx 8041 6 ) ) -RRB- cord-010092-uftc8inx 8041 7 had have VBD cord-010092-uftc8inx 8041 8 an an DT cord-010092-uftc8inx 8041 9 HIV HIV NNP cord-010092-uftc8inx 8041 10 reactive reactive JJ cord-010092-uftc8inx 8041 11 result result NN cord-010092-uftc8inx 8041 12 notified notify VBN cord-010092-uftc8inx 8041 13 by by IN cord-010092-uftc8inx 8041 14 SIVIGILA SIVIGILA NNP cord-010092-uftc8inx 8042 1 and and CC cord-010092-uftc8inx 8042 2 subsequently subsequently RB cord-010092-uftc8inx 8042 3 they -PRON- PRP cord-010092-uftc8inx 8042 4 were be VBD cord-010092-uftc8inx 8042 5 reactive reactive JJ cord-010092-uftc8inx 8042 6 in in IN cord-010092-uftc8inx 8042 7 blood blood NN cord-010092-uftc8inx 8042 8 banks bank NNS cord-010092-uftc8inx 8042 9 . . . cord-010092-uftc8inx 8043 1 This this DT cord-010092-uftc8inx 8043 2 behavior behavior NN cord-010092-uftc8inx 8043 3 may may MD cord-010092-uftc8inx 8043 4 suggest suggest VB cord-010092-uftc8inx 8043 5 an an DT cord-010092-uftc8inx 8043 6 attempt attempt NN cord-010092-uftc8inx 8043 7 to to TO cord-010092-uftc8inx 8043 8 spread spread VB cord-010092-uftc8inx 8043 9 the the DT cord-010092-uftc8inx 8043 10 disease disease NN cord-010092-uftc8inx 8043 11 . . . cord-010092-uftc8inx 8044 1 20 20 CD cord-010092-uftc8inx 8044 2 donors donor NNS cord-010092-uftc8inx 8044 3 ( ( -LRB- cord-010092-uftc8inx 8044 4 60 60 CD cord-010092-uftc8inx 8044 5 % % NN cord-010092-uftc8inx 8044 6 men man NNS cord-010092-uftc8inx 8044 7 ) ) -RRB- cord-010092-uftc8inx 8044 8 despite despite IN cord-010092-uftc8inx 8044 9 being be VBG cord-010092-uftc8inx 8044 10 initially initially RB cord-010092-uftc8inx 8044 11 reported report VBN cord-010092-uftc8inx 8044 12 in in IN cord-010092-uftc8inx 8044 13 the the DT cord-010092-uftc8inx 8044 14 SIVIGILA SIVIGILA NNP cord-010092-uftc8inx 8044 15 database database NN cord-010092-uftc8inx 8044 16 , , , cord-010092-uftc8inx 8044 17 presented present VBD cord-010092-uftc8inx 8044 18 a a DT cord-010092-uftc8inx 8044 19 non non JJ cord-010092-uftc8inx 8044 20 - - JJ cord-010092-uftc8inx 8044 21 reactive reactive JJ cord-010092-uftc8inx 8044 22 result result NN cord-010092-uftc8inx 8044 23 in in IN cord-010092-uftc8inx 8044 24 a a DT cord-010092-uftc8inx 8044 25 blood blood NN cord-010092-uftc8inx 8044 26 bank bank NN cord-010092-uftc8inx 8044 27 for for IN cord-010092-uftc8inx 8044 28 HIV HIV NNP cord-010092-uftc8inx 8044 29 ; ; : cord-010092-uftc8inx 8044 30 one one CD cord-010092-uftc8inx 8044 31 of of IN cord-010092-uftc8inx 8044 32 them -PRON- PRP cord-010092-uftc8inx 8044 33 was be VBD cord-010092-uftc8inx 8044 34 reactive reactive JJ cord-010092-uftc8inx 8044 35 for for IN cord-010092-uftc8inx 8044 36 syphilis syphili NNS cord-010092-uftc8inx 8044 37 and and CC cord-010092-uftc8inx 8044 38 HBV HBV NNP cord-010092-uftc8inx 8044 39 and and CC cord-010092-uftc8inx 8044 40 only only RB cord-010092-uftc8inx 8044 41 one one CD cord-010092-uftc8inx 8044 42 for for IN cord-010092-uftc8inx 8044 43 HBV HBV NNP cord-010092-uftc8inx 8044 44 . . . cord-010092-uftc8inx 8045 1 This this DT cord-010092-uftc8inx 8045 2 pattern pattern NN cord-010092-uftc8inx 8045 3 may may MD cord-010092-uftc8inx 8045 4 suggest suggest VB cord-010092-uftc8inx 8045 5 false false JJ cord-010092-uftc8inx 8045 6 positive positive JJ cord-010092-uftc8inx 8045 7 or or CC cord-010092-uftc8inx 8045 8 negative negative JJ cord-010092-uftc8inx 8045 9 results result NNS cord-010092-uftc8inx 8045 10 in in IN cord-010092-uftc8inx 8045 11 one one CD cord-010092-uftc8inx 8045 12 of of IN cord-010092-uftc8inx 8045 13 the the DT cord-010092-uftc8inx 8045 14 two two CD cord-010092-uftc8inx 8045 15 databases database NNS cord-010092-uftc8inx 8045 16 analyzed analyze VBN cord-010092-uftc8inx 8045 17 . . . cord-010092-uftc8inx 8046 1 Fourteen fourteen CD cord-010092-uftc8inx 8046 2 donors donor NNS cord-010092-uftc8inx 8046 3 had have VBD cord-010092-uftc8inx 8046 4 negative negative JJ cord-010092-uftc8inx 8046 5 test test NN cord-010092-uftc8inx 8046 6 in in IN cord-010092-uftc8inx 8046 7 blood blood NN cord-010092-uftc8inx 8046 8 banks bank NNS cord-010092-uftc8inx 8046 9 for for IN cord-010092-uftc8inx 8046 10 HIV HIV NNP cord-010092-uftc8inx 8046 11 and and CC cord-010092-uftc8inx 8046 12 in in IN cord-010092-uftc8inx 8046 13 a a DT cord-010092-uftc8inx 8046 14 range range NN cord-010092-uftc8inx 8046 15 of of IN cord-010092-uftc8inx 8046 16 up up IN cord-010092-uftc8inx 8046 17 to to TO cord-010092-uftc8inx 8046 18 6 6 CD cord-010092-uftc8inx 8046 19 months month NNS cord-010092-uftc8inx 8047 1 they -PRON- PRP cord-010092-uftc8inx 8047 2 were be VBD cord-010092-uftc8inx 8047 3 reactive reactive JJ cord-010092-uftc8inx 8047 4 by by IN cord-010092-uftc8inx 8047 5 SIVIGILA SIVIGILA NNP cord-010092-uftc8inx 8048 1 ( ( -LRB- cord-010092-uftc8inx 8048 2 93 93 CD cord-010092-uftc8inx 8048 3 % % NN cord-010092-uftc8inx 8048 4 of of IN cord-010092-uftc8inx 8048 5 them -PRON- PRP cord-010092-uftc8inx 8048 6 donate donate VBP cord-010092-uftc8inx 8048 7 whole whole JJ cord-010092-uftc8inx 8048 8 blood blood NN cord-010092-uftc8inx 8048 9 ) ) -RRB- cord-010092-uftc8inx 8048 10 . . . cord-010092-uftc8inx 8049 1 This this DT cord-010092-uftc8inx 8049 2 conduct conduct NN cord-010092-uftc8inx 8049 3 may may MD cord-010092-uftc8inx 8049 4 suggest suggest VB cord-010092-uftc8inx 8049 5 that that IN cord-010092-uftc8inx 8049 6 accepted accept VBN cord-010092-uftc8inx 8049 7 donations donation NNS cord-010092-uftc8inx 8049 8 were be VBD cord-010092-uftc8inx 8049 9 in in IN cord-010092-uftc8inx 8049 10 a a DT cord-010092-uftc8inx 8049 11 window window NN cord-010092-uftc8inx 8049 12 period period NN cord-010092-uftc8inx 8049 13 and and CC cord-010092-uftc8inx 8049 14 therefore therefore RB cord-010092-uftc8inx 8049 15 warrant warrant VBP cord-010092-uftc8inx 8049 16 further further JJ cord-010092-uftc8inx 8049 17 investigation investigation NN cord-010092-uftc8inx 8049 18 . . . cord-010092-uftc8inx 8050 1 Considering consider VBG cord-010092-uftc8inx 8050 2 that that IN cord-010092-uftc8inx 8050 3 two two CD cord-010092-uftc8inx 8050 4 blood blood NN cord-010092-uftc8inx 8050 5 components component NNS cord-010092-uftc8inx 8050 6 could could MD cord-010092-uftc8inx 8050 7 be be VB cord-010092-uftc8inx 8050 8 obtained obtain VBN cord-010092-uftc8inx 8050 9 on on IN cord-010092-uftc8inx 8050 10 average average JJ cord-010092-uftc8inx 8050 11 from from IN cord-010092-uftc8inx 8050 12 each each DT cord-010092-uftc8inx 8050 13 donor donor NN cord-010092-uftc8inx 8050 14 , , , cord-010092-uftc8inx 8050 15 a a DT cord-010092-uftc8inx 8050 16 potential potential JJ cord-010092-uftc8inx 8050 17 risk risk NN cord-010092-uftc8inx 8050 18 is be VBZ cord-010092-uftc8inx 8050 19 estimated estimate VBN cord-010092-uftc8inx 8050 20 for for IN cord-010092-uftc8inx 8050 21 28 28 CD cord-010092-uftc8inx 8050 22 recipients recipient NNS cord-010092-uftc8inx 8050 23 . . . cord-010092-uftc8inx 8051 1 Summary Summary NNP cord-010092-uftc8inx 8051 2 / / SYM cord-010092-uftc8inx 8051 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 8051 4 : : : cord-010092-uftc8inx 8052 1 The the DT cord-010092-uftc8inx 8052 2 donors donor NNS cord-010092-uftc8inx 8052 3 reported report VBD cord-010092-uftc8inx 8052 4 first first RB cord-010092-uftc8inx 8052 5 in in IN cord-010092-uftc8inx 8052 6 the the DT cord-010092-uftc8inx 8052 7 blood blood NN cord-010092-uftc8inx 8052 8 banks bank NNS cord-010092-uftc8inx 8052 9 through through IN cord-010092-uftc8inx 8052 10 SIHEVI SIHEVI NNP cord-010092-uftc8inx 8052 11 - - HYPH cord-010092-uftc8inx 8052 12 INS INS NNP cord-010092-uftc8inx 8052 13 © © NN cord-010092-uftc8inx 8052 14 and and CC cord-010092-uftc8inx 8052 15 later later RB cord-010092-uftc8inx 8052 16 in in IN cord-010092-uftc8inx 8052 17 SIVIGILA SIVIGILA NNP cord-010092-uftc8inx 8052 18 allow allow VBP cord-010092-uftc8inx 8052 19 to to TO cord-010092-uftc8inx 8052 20 estimate estimate VB cord-010092-uftc8inx 8052 21 an an DT cord-010092-uftc8inx 8052 22 adequate adequate JJ cord-010092-uftc8inx 8052 23 orientation orientation NN cord-010092-uftc8inx 8052 24 to to IN cord-010092-uftc8inx 8052 25 the the DT cord-010092-uftc8inx 8052 26 health health NN cord-010092-uftc8inx 8052 27 services service NNS cord-010092-uftc8inx 8052 28 . . . cord-010092-uftc8inx 8053 1 The the DT cord-010092-uftc8inx 8053 2 information information NN cord-010092-uftc8inx 8053 3 from from IN cord-010092-uftc8inx 8053 4 general general JJ cord-010092-uftc8inx 8053 5 epidemiological epidemiological JJ cord-010092-uftc8inx 8053 6 surveillance surveillance NN cord-010092-uftc8inx 8053 7 programs program NNS cord-010092-uftc8inx 8053 8 could could MD cord-010092-uftc8inx 8053 9 improve improve VB cord-010092-uftc8inx 8053 10 the the DT cord-010092-uftc8inx 8053 11 selection selection NN cord-010092-uftc8inx 8053 12 of of IN cord-010092-uftc8inx 8053 13 donors donor NNS cord-010092-uftc8inx 8053 14 and and CC cord-010092-uftc8inx 8053 15 transfusion transfusion NN cord-010092-uftc8inx 8053 16 safety safety NN cord-010092-uftc8inx 8053 17 . . . cord-010092-uftc8inx 8054 1 Background background NN cord-010092-uftc8inx 8054 2 : : : cord-010092-uftc8inx 8055 1 It -PRON- PRP cord-010092-uftc8inx 8055 2 is be VBZ cord-010092-uftc8inx 8055 3 assumed assume VBN cord-010092-uftc8inx 8055 4 that that IN cord-010092-uftc8inx 8055 5 bacterial bacterial JJ cord-010092-uftc8inx 8055 6 contamination contamination NN cord-010092-uftc8inx 8055 7 of of IN cord-010092-uftc8inx 8055 8 blood blood NN cord-010092-uftc8inx 8055 9 products product NNS cord-010092-uftc8inx 8055 10 most most RBS cord-010092-uftc8inx 8055 11 often often RB cord-010092-uftc8inx 8055 12 takes take VBZ cord-010092-uftc8inx 8055 13 place place NN cord-010092-uftc8inx 8055 14 during during IN cord-010092-uftc8inx 8055 15 the the DT cord-010092-uftc8inx 8055 16 donation donation NN cord-010092-uftc8inx 8055 17 process process NN cord-010092-uftc8inx 8055 18 . . . cord-010092-uftc8inx 8056 1 The the DT cord-010092-uftc8inx 8056 2 number number NN cord-010092-uftc8inx 8056 3 of of IN cord-010092-uftc8inx 8056 4 bacteria bacteria NNS cord-010092-uftc8inx 8056 5 at at IN cord-010092-uftc8inx 8056 6 this this DT cord-010092-uftc8inx 8056 7 time time NN cord-010092-uftc8inx 8056 8 point point NN cord-010092-uftc8inx 8056 9 is be VBZ cord-010092-uftc8inx 8056 10 estimated estimate VBN cord-010092-uftc8inx 8056 11 to to TO cord-010092-uftc8inx 8056 12 be be VB cord-010092-uftc8inx 8056 13 around around RB cord-010092-uftc8inx 8056 14 10 10 CD cord-010092-uftc8inx 8056 15 - - SYM cord-010092-uftc8inx 8056 16 100 100 CD cord-010092-uftc8inx 8056 17 CFU cfu NN cord-010092-uftc8inx 8056 18 per per IN cord-010092-uftc8inx 8056 19 bag bag NN cord-010092-uftc8inx 8056 20 . . . cord-010092-uftc8inx 8057 1 Little little JJ cord-010092-uftc8inx 8057 2 is be VBZ cord-010092-uftc8inx 8057 3 known know VBN cord-010092-uftc8inx 8057 4 about about IN cord-010092-uftc8inx 8057 5 the the DT cord-010092-uftc8inx 8057 6 growth growth NN cord-010092-uftc8inx 8057 7 behavior behavior NN cord-010092-uftc8inx 8057 8 of of IN cord-010092-uftc8inx 8057 9 different different JJ cord-010092-uftc8inx 8057 10 bacteria bacteria NNS cord-010092-uftc8inx 8057 11 species specie NNS cord-010092-uftc8inx 8057 12 in in IN cord-010092-uftc8inx 8057 13 whole whole JJ cord-010092-uftc8inx 8057 14 blood blood NN cord-010092-uftc8inx 8057 15 ( ( -LRB- cord-010092-uftc8inx 8057 16 WB WB NNP cord-010092-uftc8inx 8057 17 ) ) -RRB- cord-010092-uftc8inx 8057 18 units unit NNS cord-010092-uftc8inx 8057 19 during during IN cord-010092-uftc8inx 8057 20 storage storage NN cord-010092-uftc8inx 8057 21 and and CC cord-010092-uftc8inx 8057 22 the the DT cord-010092-uftc8inx 8057 23 distribution distribution NN cord-010092-uftc8inx 8057 24 of of IN cord-010092-uftc8inx 8057 25 bacteria bacteria NNS cord-010092-uftc8inx 8057 26 to to IN cord-010092-uftc8inx 8057 27 the the DT cord-010092-uftc8inx 8057 28 different different JJ cord-010092-uftc8inx 8057 29 blood blood NN cord-010092-uftc8inx 8057 30 products product NNS cord-010092-uftc8inx 8057 31 . . . cord-010092-uftc8inx 8058 1 Aims aim VBZ cord-010092-uftc8inx 8058 2 : : : cord-010092-uftc8inx 8059 1 Aim aim VB cord-010092-uftc8inx 8059 2 of of IN cord-010092-uftc8inx 8059 3 the the DT cord-010092-uftc8inx 8059 4 current current JJ cord-010092-uftc8inx 8059 5 study study NN cord-010092-uftc8inx 8059 6 was be VBD cord-010092-uftc8inx 8059 7 to to TO cord-010092-uftc8inx 8059 8 determine determine VB cord-010092-uftc8inx 8059 9 the the DT cord-010092-uftc8inx 8059 10 growth growth NN cord-010092-uftc8inx 8059 11 of of IN cord-010092-uftc8inx 8059 12 different different JJ cord-010092-uftc8inx 8059 13 bacteria bacteria NNS cord-010092-uftc8inx 8059 14 species specie NNS cord-010092-uftc8inx 8059 15 in in IN cord-010092-uftc8inx 8059 16 contaminated contaminate VBN cord-010092-uftc8inx 8059 17 WB WB NNP cord-010092-uftc8inx 8059 18 units unit NNS cord-010092-uftc8inx 8059 19 and and CC cord-010092-uftc8inx 8059 20 to to TO cord-010092-uftc8inx 8059 21 study study VB cord-010092-uftc8inx 8059 22 the the DT cord-010092-uftc8inx 8059 23 distribution distribution NN cord-010092-uftc8inx 8059 24 of of IN cord-010092-uftc8inx 8059 25 the the DT cord-010092-uftc8inx 8059 26 bacteria bacteria NNS cord-010092-uftc8inx 8059 27 to to IN cord-010092-uftc8inx 8059 28 the the DT cord-010092-uftc8inx 8059 29 different different JJ cord-010092-uftc8inx 8059 30 blood blood NN cord-010092-uftc8inx 8059 31 components component NNS cord-010092-uftc8inx 8059 32 . . . cord-010092-uftc8inx 8060 1 Methods method NNS cord-010092-uftc8inx 8060 2 : : : cord-010092-uftc8inx 8060 3 Whole whole JJ cord-010092-uftc8inx 8060 4 blood blood NN cord-010092-uftc8inx 8060 5 ( ( -LRB- cord-010092-uftc8inx 8060 6 n n NN cord-010092-uftc8inx 8060 7 = = SYM cord-010092-uftc8inx 8060 8 4 4 CD cord-010092-uftc8inx 8060 9 - - SYM cord-010092-uftc8inx 8060 10 12 12 CD cord-010092-uftc8inx 8060 11 per per IN cord-010092-uftc8inx 8060 12 species specie NNS cord-010092-uftc8inx 8060 13 ) ) -RRB- cord-010092-uftc8inx 8060 14 was be VBD cord-010092-uftc8inx 8060 15 inoculated inoculate VBN cord-010092-uftc8inx 8060 16 with with IN cord-010092-uftc8inx 8060 17 approximately approximately RB cord-010092-uftc8inx 8060 18 10 10 CD cord-010092-uftc8inx 8060 19 CFU CFU NNP cord-010092-uftc8inx 8060 20 of of IN cord-010092-uftc8inx 8060 21 different different JJ cord-010092-uftc8inx 8060 22 bacteria bacteria NNS cord-010092-uftc8inx 8060 23 species specie NNS cord-010092-uftc8inx 8060 24 ( ( -LRB- cord-010092-uftc8inx 8060 25 Escherichia escherichia NN cord-010092-uftc8inx 8060 26 coli coli NNS cord-010092-uftc8inx 8060 27 , , , cord-010092-uftc8inx 8060 28 Klebsiella Klebsiella NNP cord-010092-uftc8inx 8060 29 pneumoniae pneumoniae NN cord-010092-uftc8inx 8060 30 , , , cord-010092-uftc8inx 8060 31 Pseudomonas Pseudomonas NNP cord-010092-uftc8inx 8060 32 fluorescens fluorescen NNS cord-010092-uftc8inx 8060 33 , , , cord-010092-uftc8inx 8060 34 Staphylococcus Staphylococcus NNP cord-010092-uftc8inx 8060 35 aureus aureus NN cord-010092-uftc8inx 8060 36 , , , cord-010092-uftc8inx 8060 37 Staphylococcus Staphylococcus NNP cord-010092-uftc8inx 8060 38 epidermidis epidermidi NNS cord-010092-uftc8inx 8060 39 , , , cord-010092-uftc8inx 8060 40 Streptococcus streptococcus NN cord-010092-uftc8inx 8060 41 dysgalactiae dysgalactiae NN cord-010092-uftc8inx 8060 42 , , , cord-010092-uftc8inx 8060 43 Streptococcus streptococcus NN cord-010092-uftc8inx 8060 44 pyogenes pyogene NNS cord-010092-uftc8inx 8060 45 ) ) -RRB- cord-010092-uftc8inx 8060 46 and and CC cord-010092-uftc8inx 8060 47 stored store VBN cord-010092-uftc8inx 8060 48 for for IN cord-010092-uftc8inx 8060 49 22 22 CD cord-010092-uftc8inx 8060 50 to to TO cord-010092-uftc8inx 8060 51 24 24 CD cord-010092-uftc8inx 8060 52 h h NN cord-010092-uftc8inx 8060 53 at at IN cord-010092-uftc8inx 8060 54 room room NN cord-010092-uftc8inx 8060 55 temperature temperature NN cord-010092-uftc8inx 8060 56 before before IN cord-010092-uftc8inx 8060 57 centrifugation centrifugation NN cord-010092-uftc8inx 8060 58 and and CC cord-010092-uftc8inx 8060 59 separation separation NN cord-010092-uftc8inx 8060 60 into into IN cord-010092-uftc8inx 8060 61 red red JJ cord-010092-uftc8inx 8060 62 blood blood NN cord-010092-uftc8inx 8060 63 cells cell NNS cord-010092-uftc8inx 8060 64 ( ( -LRB- cord-010092-uftc8inx 8060 65 RBC RBC NNP cord-010092-uftc8inx 8060 66 ) ) -RRB- cord-010092-uftc8inx 8060 67 , , , cord-010092-uftc8inx 8060 68 buffy buffy NNP cord-010092-uftc8inx 8060 69 coat coat NNP cord-010092-uftc8inx 8060 70 ( ( -LRB- cord-010092-uftc8inx 8060 71 BC BC NNP cord-010092-uftc8inx 8060 72 ) ) -RRB- cord-010092-uftc8inx 8060 73 and and CC cord-010092-uftc8inx 8060 74 plasma plasma NN cord-010092-uftc8inx 8060 75 . . . cord-010092-uftc8inx 8061 1 BCs BCs NNP cord-010092-uftc8inx 8061 2 from from IN cord-010092-uftc8inx 8061 3 spiked spiked JJ cord-010092-uftc8inx 8061 4 WB WB NNP cord-010092-uftc8inx 8061 5 were be VBD cord-010092-uftc8inx 8061 6 each each DT cord-010092-uftc8inx 8061 7 pooled pool VBN cord-010092-uftc8inx 8061 8 with with IN cord-010092-uftc8inx 8061 9 3 3 CD cord-010092-uftc8inx 8061 10 random random JJ cord-010092-uftc8inx 8061 11 BCs bc NNS cord-010092-uftc8inx 8061 12 to to TO cord-010092-uftc8inx 8061 13 prepare prepare VB cord-010092-uftc8inx 8061 14 plasmareduced plasmareduced JJ cord-010092-uftc8inx 8061 15 platelet platelet NN cord-010092-uftc8inx 8061 16 concentrates concentrate NNS cord-010092-uftc8inx 8061 17 ( ( -LRB- cord-010092-uftc8inx 8061 18 PC pc NN cord-010092-uftc8inx 8061 19 ) ) -RRB- cord-010092-uftc8inx 8061 20 . . . cord-010092-uftc8inx 8062 1 Samples sample NNS cord-010092-uftc8inx 8062 2 were be VBD cord-010092-uftc8inx 8062 3 taken take VBN cord-010092-uftc8inx 8062 4 from from IN cord-010092-uftc8inx 8062 5 WB WB NNP cord-010092-uftc8inx 8062 6 after after IN cord-010092-uftc8inx 8062 7 storage storage NN cord-010092-uftc8inx 8062 8 and and CC cord-010092-uftc8inx 8062 9 from from IN cord-010092-uftc8inx 8062 10 the the DT cord-010092-uftc8inx 8062 11 blood blood NN cord-010092-uftc8inx 8062 12 products product NNS cord-010092-uftc8inx 8062 13 ( ( -LRB- cord-010092-uftc8inx 8062 14 RBC RBC NNP cord-010092-uftc8inx 8062 15 , , , cord-010092-uftc8inx 8062 16 BC BC NNP cord-010092-uftc8inx 8062 17 , , , cord-010092-uftc8inx 8062 18 plasma plasma NN cord-010092-uftc8inx 8062 19 and and CC cord-010092-uftc8inx 8062 20 PC pc NN cord-010092-uftc8inx 8062 21 ) ) -RRB- cord-010092-uftc8inx 8063 1 right right RB cord-010092-uftc8inx 8063 2 after after IN cord-010092-uftc8inx 8063 3 preparation preparation NN cord-010092-uftc8inx 8063 4 , , , cord-010092-uftc8inx 8063 5 and and CC cord-010092-uftc8inx 8063 6 the the DT cord-010092-uftc8inx 8063 7 bacterial bacterial JJ cord-010092-uftc8inx 8063 8 titer titer NN cord-010092-uftc8inx 8063 9 was be VBD cord-010092-uftc8inx 8063 10 determined determine VBN cord-010092-uftc8inx 8063 11 . . . cord-010092-uftc8inx 8064 1 Sterility sterility NN cord-010092-uftc8inx 8064 2 of of IN cord-010092-uftc8inx 8064 3 PCs pc NNS cord-010092-uftc8inx 8064 4 was be VBD cord-010092-uftc8inx 8064 5 tested test VBN cord-010092-uftc8inx 8064 6 by by IN cord-010092-uftc8inx 8064 7 BacT BacT NNP cord-010092-uftc8inx 8064 8 / / SYM cord-010092-uftc8inx 8064 9 Alert Alert NNP cord-010092-uftc8inx 8064 10 after after IN cord-010092-uftc8inx 8064 11 seven seven CD cord-010092-uftc8inx 8064 12 days day NNS cord-010092-uftc8inx 8064 13 of of IN cord-010092-uftc8inx 8064 14 storage storage NN cord-010092-uftc8inx 8064 15 . . . cord-010092-uftc8inx 8065 1 Results result NNS cord-010092-uftc8inx 8065 2 : : : cord-010092-uftc8inx 8065 3 Bacterial bacterial JJ cord-010092-uftc8inx 8065 4 growth growth NN cord-010092-uftc8inx 8065 5 in in IN cord-010092-uftc8inx 8065 6 WB WB NNP cord-010092-uftc8inx 8065 7 varied vary VBD cord-010092-uftc8inx 8065 8 remarkably remarkably RB cord-010092-uftc8inx 8065 9 between between IN cord-010092-uftc8inx 8065 10 donations donation NNS cord-010092-uftc8inx 8065 11 and and CC cord-010092-uftc8inx 8065 12 bacteria bacteria NNS cord-010092-uftc8inx 8065 13 species specie NNS cord-010092-uftc8inx 8065 14 . . . cord-010092-uftc8inx 8066 1 The the DT cord-010092-uftc8inx 8066 2 highest high JJS cord-010092-uftc8inx 8066 3 titers titer NNS cord-010092-uftc8inx 8066 4 in in IN cord-010092-uftc8inx 8066 5 WB WB NNP cord-010092-uftc8inx 8066 6 were be VBD cord-010092-uftc8inx 8066 7 detected detect VBN cord-010092-uftc8inx 8066 8 for for IN cord-010092-uftc8inx 8066 9 the the DT cord-010092-uftc8inx 8066 10 Streptococcus Streptococcus NNP cord-010092-uftc8inx 8066 11 species specie NNS cord-010092-uftc8inx 8066 12 , , , cord-010092-uftc8inx 8066 13 whereas whereas IN cord-010092-uftc8inx 8066 14 Staphylococcus Staphylococcus NNP cord-010092-uftc8inx 8066 15 aureus aureus NN cord-010092-uftc8inx 8066 16 , , , cord-010092-uftc8inx 8066 17 Staphylococcus Staphylococcus NNP cord-010092-uftc8inx 8066 18 epidermidis epidermidi NNS cord-010092-uftc8inx 8066 19 , , , cord-010092-uftc8inx 8066 20 Escherichia Escherichia NNP cord-010092-uftc8inx 8066 21 coli coli NNS cord-010092-uftc8inx 8066 22 and and CC cord-010092-uftc8inx 8066 23 Pseudomonas Pseudomonas NNP cord-010092-uftc8inx 8066 24 fluorescens fluorescen NNS cord-010092-uftc8inx 8066 25 did do VBD cord-010092-uftc8inx 8066 26 not not RB cord-010092-uftc8inx 8066 27 multiply multiply VB cord-010092-uftc8inx 8066 28 . . . cord-010092-uftc8inx 8067 1 Bacteria Bacteria NNS cord-010092-uftc8inx 8067 2 preferably preferably RB cord-010092-uftc8inx 8067 3 accumulated accumulate VBN cord-010092-uftc8inx 8067 4 in in IN cord-010092-uftc8inx 8067 5 the the DT cord-010092-uftc8inx 8067 6 BCs BCs NNPS cord-010092-uftc8inx 8067 7 during during IN cord-010092-uftc8inx 8067 8 separation separation NN cord-010092-uftc8inx 8067 9 , , , cord-010092-uftc8inx 8067 10 reaching reach VBG cord-010092-uftc8inx 8067 11 titers titer NNS cord-010092-uftc8inx 8067 12 of of IN cord-010092-uftc8inx 8067 13 up up IN cord-010092-uftc8inx 8067 14 to to TO cord-010092-uftc8inx 8067 15 3.5 3.5 CD cord-010092-uftc8inx 8067 16 9 9 CD cord-010092-uftc8inx 8067 17 10 10 CD cord-010092-uftc8inx 8067 18 3 3 CD cord-010092-uftc8inx 8067 19 CFU CFU NNP cord-010092-uftc8inx 8067 20 / / SYM cord-010092-uftc8inx 8067 21 mL ml NN cord-010092-uftc8inx 8067 22 in in IN cord-010092-uftc8inx 8067 23 BCs BCs NNP cord-010092-uftc8inx 8067 24 and and CC cord-010092-uftc8inx 8067 25 up up IN cord-010092-uftc8inx 8067 26 to to TO cord-010092-uftc8inx 8067 27 0.9 0.9 CD cord-010092-uftc8inx 8067 28 9 9 CD cord-010092-uftc8inx 8067 29 10 10 CD cord-010092-uftc8inx 8067 30 3 3 CD cord-010092-uftc8inx 8067 31 CFU CFU NNP cord-010092-uftc8inx 8067 32 / / SYM cord-010092-uftc8inx 8067 33 mL ml NN cord-010092-uftc8inx 8067 34 in in IN cord-010092-uftc8inx 8067 35 the the DT cord-010092-uftc8inx 8067 36 corresponding correspond VBG cord-010092-uftc8inx 8067 37 PCs pc NNS cord-010092-uftc8inx 8067 38 right right RB cord-010092-uftc8inx 8067 39 after after IN cord-010092-uftc8inx 8067 40 preparation preparation NN cord-010092-uftc8inx 8067 41 . . . cord-010092-uftc8inx 8068 1 In in IN cord-010092-uftc8inx 8068 2 total total NN cord-010092-uftc8inx 8068 3 , , , cord-010092-uftc8inx 8068 4 33 33 CD cord-010092-uftc8inx 8068 5 out out IN cord-010092-uftc8inx 8068 6 of of IN cord-010092-uftc8inx 8068 7 48 48 CD cord-010092-uftc8inx 8068 8 PCs pc NNS cord-010092-uftc8inx 8068 9 tested test VBD cord-010092-uftc8inx 8068 10 positive positive JJ cord-010092-uftc8inx 8068 11 for for IN cord-010092-uftc8inx 8068 12 bacteria bacteria NNS cord-010092-uftc8inx 8068 13 at at IN cord-010092-uftc8inx 8068 14 the the DT cord-010092-uftc8inx 8068 15 end end NN cord-010092-uftc8inx 8068 16 of of IN cord-010092-uftc8inx 8068 17 storage storage NN cord-010092-uftc8inx 8068 18 . . . cord-010092-uftc8inx 8069 1 The the DT cord-010092-uftc8inx 8069 2 results result NNS cord-010092-uftc8inx 8069 3 were be VBD cord-010092-uftc8inx 8069 4 dependent dependent JJ cord-010092-uftc8inx 8069 5 on on IN cord-010092-uftc8inx 8069 6 the the DT cord-010092-uftc8inx 8069 7 species species NN cord-010092-uftc8inx 8069 8 used use VBN cord-010092-uftc8inx 8069 9 : : : cord-010092-uftc8inx 8069 10 e.g. e.g. RB cord-010092-uftc8inx 8069 11 , , , cord-010092-uftc8inx 8069 12 6/6 6/6 CD cord-010092-uftc8inx 8069 13 PCs pc NNS cord-010092-uftc8inx 8069 14 tested test VBD cord-010092-uftc8inx 8069 15 positive positive JJ cord-010092-uftc8inx 8069 16 after after IN cord-010092-uftc8inx 8069 17 spiking spike VBG cord-010092-uftc8inx 8069 18 with with IN cord-010092-uftc8inx 8069 19 Streptococcus streptococcus NN cord-010092-uftc8inx 8069 20 pyogenes pyogene NNS cord-010092-uftc8inx 8069 21 , , , cord-010092-uftc8inx 8069 22 while while IN cord-010092-uftc8inx 8069 23 only only RB cord-010092-uftc8inx 8069 24 1/8 1/8 CD cord-010092-uftc8inx 8069 25 PCs pc NNS cord-010092-uftc8inx 8069 26 tested test VBD cord-010092-uftc8inx 8069 27 positive positive JJ cord-010092-uftc8inx 8069 28 after after IN cord-010092-uftc8inx 8069 29 spiking spike VBG cord-010092-uftc8inx 8069 30 with with IN cord-010092-uftc8inx 8069 31 Escherichia Escherichia NNP cord-010092-uftc8inx 8069 32 coli coli NNS cord-010092-uftc8inx 8069 33 . . . cord-010092-uftc8inx 8070 1 Bacterial bacterial JJ cord-010092-uftc8inx 8070 2 contamination contamination NN cord-010092-uftc8inx 8070 3 of of IN cord-010092-uftc8inx 8070 4 RBC RBC NNP cord-010092-uftc8inx 8070 5 and and CC cord-010092-uftc8inx 8070 6 plasma plasma NN cord-010092-uftc8inx 8070 7 units unit NNS cord-010092-uftc8inx 8070 8 was be VBD cord-010092-uftc8inx 8070 9 much much RB cord-010092-uftc8inx 8070 10 less less RBR cord-010092-uftc8inx 8070 11 frequent frequent JJ cord-010092-uftc8inx 8070 12 and and CC cord-010092-uftc8inx 8070 13 associated associate VBN cord-010092-uftc8inx 8070 14 with with IN cord-010092-uftc8inx 8070 15 higher high JJR cord-010092-uftc8inx 8070 16 bacterial bacterial JJ cord-010092-uftc8inx 8070 17 titers titer NNS cord-010092-uftc8inx 8070 18 in in IN cord-010092-uftc8inx 8070 19 the the DT cord-010092-uftc8inx 8070 20 parental parental JJ cord-010092-uftc8inx 8070 21 WB WB NNP cord-010092-uftc8inx 8070 22 units unit NNS cord-010092-uftc8inx 8070 23 . . . cord-010092-uftc8inx 8071 1 Summary Summary NNP cord-010092-uftc8inx 8071 2 / / SYM cord-010092-uftc8inx 8071 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 8071 4 : : : cord-010092-uftc8inx 8072 1 The the DT cord-010092-uftc8inx 8072 2 growth growth NN cord-010092-uftc8inx 8072 3 and and CC cord-010092-uftc8inx 8072 4 distribution distribution NN cord-010092-uftc8inx 8072 5 of of IN cord-010092-uftc8inx 8072 6 bacteria bacteria NNS cord-010092-uftc8inx 8072 7 during during IN cord-010092-uftc8inx 8072 8 processing processing NN cord-010092-uftc8inx 8072 9 of of IN cord-010092-uftc8inx 8072 10 WB WB NNP cord-010092-uftc8inx 8072 11 into into IN cord-010092-uftc8inx 8072 12 the the DT cord-010092-uftc8inx 8072 13 different different JJ cord-010092-uftc8inx 8072 14 blood blood NN cord-010092-uftc8inx 8072 15 products product NNS cord-010092-uftc8inx 8072 16 is be VBZ cord-010092-uftc8inx 8072 17 species species NN cord-010092-uftc8inx 8072 18 - - HYPH cord-010092-uftc8inx 8072 19 dependent dependent JJ cord-010092-uftc8inx 8072 20 and and CC cord-010092-uftc8inx 8072 21 remarkably remarkably RB cord-010092-uftc8inx 8072 22 varies vary VBZ cord-010092-uftc8inx 8072 23 between between IN cord-010092-uftc8inx 8072 24 donations donation NNS cord-010092-uftc8inx 8072 25 . . . cord-010092-uftc8inx 8073 1 Results result NNS cord-010092-uftc8inx 8073 2 : : : cord-010092-uftc8inx 8074 1 Both both DT cord-010092-uftc8inx 8074 2 patients patient NNS cord-010092-uftc8inx 8074 3 were be VBD cord-010092-uftc8inx 8074 4 male male JJ cord-010092-uftc8inx 8074 5 ( ( -LRB- cord-010092-uftc8inx 8074 6 69 69 CD cord-010092-uftc8inx 8074 7 yo yo NN cord-010092-uftc8inx 8074 8 and and CC cord-010092-uftc8inx 8074 9 65 65 CD cord-010092-uftc8inx 8074 10 yo yo UH cord-010092-uftc8inx 8074 11 ) ) -RRB- cord-010092-uftc8inx 8074 12 with with IN cord-010092-uftc8inx 8074 13 a a DT cord-010092-uftc8inx 8074 14 history history NN cord-010092-uftc8inx 8074 15 of of IN cord-010092-uftc8inx 8074 16 acute acute JJ cord-010092-uftc8inx 8074 17 myelogenous myelogenous NN cord-010092-uftc8inx 8074 18 leukemia leukemia NN cord-010092-uftc8inx 8074 19 status status NN cord-010092-uftc8inx 8074 20 - - HYPH cord-010092-uftc8inx 8074 21 post post JJ cord-010092-uftc8inx 8074 22 haploidentical haploidentical JJ cord-010092-uftc8inx 8074 23 stem stem NN cord-010092-uftc8inx 8074 24 cell cell NN cord-010092-uftc8inx 8074 25 transplant transplant NN cord-010092-uftc8inx 8074 26 . . . cord-010092-uftc8inx 8075 1 The the DT cord-010092-uftc8inx 8075 2 patients patient NNS cord-010092-uftc8inx 8075 3 were be VBD cord-010092-uftc8inx 8075 4 thrombocytopenic thrombocytopenic JJ cord-010092-uftc8inx 8075 5 and and CC cord-010092-uftc8inx 8075 6 underwent undergo VBD cord-010092-uftc8inx 8075 7 simultaneous simultaneous JJ cord-010092-uftc8inx 8075 8 transfusion transfusion NN cord-010092-uftc8inx 8075 9 of of IN cord-010092-uftc8inx 8075 10 irradiated irradiate VBN cord-010092-uftc8inx 8075 11 , , , cord-010092-uftc8inx 8075 12 non non JJ cord-010092-uftc8inx 8075 13 - - JJ cord-010092-uftc8inx 8075 14 PR pr JJ cord-010092-uftc8inx 8075 15 , , , cord-010092-uftc8inx 8075 16 day day NN cord-010092-uftc8inx 8075 17 4 4 CD cord-010092-uftc8inx 8075 18 platelets platelet NNS cord-010092-uftc8inx 8075 19 stored store VBN cord-010092-uftc8inx 8075 20 in in IN cord-010092-uftc8inx 8075 21 platelet platelet NN cord-010092-uftc8inx 8075 22 additive additive NN cord-010092-uftc8inx 8075 23 solution solution NN cord-010092-uftc8inx 8075 24 , , , cord-010092-uftc8inx 8075 25 from from IN cord-010092-uftc8inx 8075 26 a a DT cord-010092-uftc8inx 8075 27 single single JJ cord-010092-uftc8inx 8075 28 apheresis apheresis NN cord-010092-uftc8inx 8075 29 collection collection NN cord-010092-uftc8inx 8075 30 . . . cord-010092-uftc8inx 8076 1 The the DT cord-010092-uftc8inx 8076 2 blood blood NN cord-010092-uftc8inx 8076 3 supplier supplier NN cord-010092-uftc8inx 8076 4 's 's POS cord-010092-uftc8inx 8076 5 primary primary JJ cord-010092-uftc8inx 8076 6 pre pre JJ cord-010092-uftc8inx 8076 7 - - JJ cord-010092-uftc8inx 8076 8 release release JJ cord-010092-uftc8inx 8076 9 bacterial bacterial JJ cord-010092-uftc8inx 8076 10 cultures culture NNS cord-010092-uftc8inx 8076 11 were be VBD cord-010092-uftc8inx 8076 12 negative negative JJ cord-010092-uftc8inx 8076 13 , , , cord-010092-uftc8inx 8076 14 and and CC cord-010092-uftc8inx 8076 15 the the DT cord-010092-uftc8inx 8076 16 on on IN cord-010092-uftc8inx 8076 17 - - HYPH cord-010092-uftc8inx 8076 18 site site NN cord-010092-uftc8inx 8076 19 point point NN cord-010092-uftc8inx 8076 20 of of IN cord-010092-uftc8inx 8076 21 release release JJ cord-010092-uftc8inx 8076 22 secondary secondary JJ cord-010092-uftc8inx 8076 23 safety safety NN cord-010092-uftc8inx 8076 24 measure measure NN cord-010092-uftc8inx 8077 1 pan pan NNP cord-010092-uftc8inx 8077 2 genera genera NNP cord-010092-uftc8inx 8077 3 detection detection NN cord-010092-uftc8inx 8077 4 ( ( -LRB- cord-010092-uftc8inx 8077 5 PGD PGD NNP cord-010092-uftc8inx 8077 6 ) ) -RRB- cord-010092-uftc8inx 8077 7 testing testing NN cord-010092-uftc8inx 8077 8 was be VBD cord-010092-uftc8inx 8077 9 negative negative JJ cord-010092-uftc8inx 8077 10 for for IN cord-010092-uftc8inx 8077 11 both both CC cord-010092-uftc8inx 8077 12 Gram Gram NNP cord-010092-uftc8inx 8077 13 positive positive JJ cord-010092-uftc8inx 8077 14 ( ( -LRB- cord-010092-uftc8inx 8077 15 GP gp NN cord-010092-uftc8inx 8077 16 ) ) -RRB- cord-010092-uftc8inx 8077 17 and and CC cord-010092-uftc8inx 8077 18 Gram Gram NNP cord-010092-uftc8inx 8077 19 negative negative JJ cord-010092-uftc8inx 8077 20 ( ( -LRB- cord-010092-uftc8inx 8077 21 GN GN NNP cord-010092-uftc8inx 8077 22 ) ) -RRB- cord-010092-uftc8inx 8077 23 organisms organism NNS cord-010092-uftc8inx 8077 24 . . . cord-010092-uftc8inx 8078 1 Both both DT cord-010092-uftc8inx 8078 2 apheresis apheresis NN cord-010092-uftc8inx 8078 3 units unit NNS cord-010092-uftc8inx 8078 4 also also RB cord-010092-uftc8inx 8078 5 passed pass VBD cord-010092-uftc8inx 8078 6 visual visual JJ cord-010092-uftc8inx 8078 7 inspection inspection NN cord-010092-uftc8inx 8078 8 prior prior RB cord-010092-uftc8inx 8078 9 to to TO cord-010092-uftc8inx 8078 10 release release VB cord-010092-uftc8inx 8078 11 from from IN cord-010092-uftc8inx 8078 12 the the DT cord-010092-uftc8inx 8078 13 blood blood NN cord-010092-uftc8inx 8078 14 bank bank NN cord-010092-uftc8inx 8078 15 . . . cord-010092-uftc8inx 8079 1 During during IN cord-010092-uftc8inx 8079 2 transfusion transfusion NN cord-010092-uftc8inx 8079 3 , , , cord-010092-uftc8inx 8079 4 both both DT cord-010092-uftc8inx 8079 5 patients patient NNS cord-010092-uftc8inx 8079 6 displayed display VBD cord-010092-uftc8inx 8079 7 signs sign NNS cord-010092-uftc8inx 8079 8 of of IN cord-010092-uftc8inx 8079 9 septic septic JJ cord-010092-uftc8inx 8079 10 transfusion transfusion NN cord-010092-uftc8inx 8079 11 reaction reaction NN cord-010092-uftc8inx 8079 12 including include VBG cord-010092-uftc8inx 8079 13 rigors rigor NNS cord-010092-uftc8inx 8079 14 , , , cord-010092-uftc8inx 8079 15 fever fever NN cord-010092-uftc8inx 8079 16 , , , cord-010092-uftc8inx 8079 17 hypoxemia hypoxemia NN cord-010092-uftc8inx 8079 18 , , , cord-010092-uftc8inx 8079 19 tachypnea tachypnea NNP cord-010092-uftc8inx 8079 20 , , , cord-010092-uftc8inx 8079 21 tachycardia tachycardia NN cord-010092-uftc8inx 8079 22 , , , cord-010092-uftc8inx 8079 23 and and CC cord-010092-uftc8inx 8079 24 hypotension hypotension NN cord-010092-uftc8inx 8079 25 . . . cord-010092-uftc8inx 8080 1 Transfusion transfusion NN cord-010092-uftc8inx 8080 2 reaction reaction NN cord-010092-uftc8inx 8080 3 evaluations evaluation NNS cord-010092-uftc8inx 8080 4 were be VBD cord-010092-uftc8inx 8080 5 initiated initiate VBN cord-010092-uftc8inx 8080 6 , , , cord-010092-uftc8inx 8080 7 and and CC cord-010092-uftc8inx 8080 8 both both DT cord-010092-uftc8inx 8080 9 patients patient NNS cord-010092-uftc8inx 8080 10 were be VBD cord-010092-uftc8inx 8080 11 admitted admit VBN cord-010092-uftc8inx 8080 12 to to IN cord-010092-uftc8inx 8080 13 the the DT cord-010092-uftc8inx 8080 14 medical medical JJ cord-010092-uftc8inx 8080 15 intensive intensive JJ cord-010092-uftc8inx 8080 16 care care NN cord-010092-uftc8inx 8080 17 unit unit NN cord-010092-uftc8inx 8080 18 and and CC cord-010092-uftc8inx 8080 19 started start VBD cord-010092-uftc8inx 8080 20 on on IN cord-010092-uftc8inx 8080 21 broad broad JJ cord-010092-uftc8inx 8080 22 - - HYPH cord-010092-uftc8inx 8080 23 spectrum spectrum NN cord-010092-uftc8inx 8080 24 antibiotics antibiotic NNS cord-010092-uftc8inx 8080 25 . . . cord-010092-uftc8inx 8081 1 Gram gram NN cord-010092-uftc8inx 8081 2 stain stain NN cord-010092-uftc8inx 8081 3 of of IN cord-010092-uftc8inx 8081 4 one one CD cord-010092-uftc8inx 8081 5 platelet platelet NN cord-010092-uftc8inx 8081 6 unit unit NN cord-010092-uftc8inx 8081 7 demonstrated demonstrate VBD cord-010092-uftc8inx 8081 8 Gram Gram NNP cord-010092-uftc8inx 8081 9 negative negative JJ cord-010092-uftc8inx 8081 10 rods rod NNS cord-010092-uftc8inx 8081 11 ( ( -LRB- cord-010092-uftc8inx 8081 12 GNR GNR NNP cord-010092-uftc8inx 8081 13 ) ) -RRB- cord-010092-uftc8inx 8081 14 and and CC cord-010092-uftc8inx 8081 15 Gram Gram NNP cord-010092-uftc8inx 8081 16 positive positive JJ cord-010092-uftc8inx 8081 17 cocci coccus NNS cord-010092-uftc8inx 8081 18 ( ( -LRB- cord-010092-uftc8inx 8081 19 GPC GPC NNP cord-010092-uftc8inx 8081 20 ) ) -RRB- cord-010092-uftc8inx 8081 21 in in IN cord-010092-uftc8inx 8081 22 clusters cluster NNS cord-010092-uftc8inx 8081 23 , , , cord-010092-uftc8inx 8081 24 and and CC cord-010092-uftc8inx 8081 25 the the DT cord-010092-uftc8inx 8081 26 second second JJ cord-010092-uftc8inx 8081 27 platelet platelet NN cord-010092-uftc8inx 8081 28 unit unit NN cord-010092-uftc8inx 8081 29 demonstrated demonstrate VBD cord-010092-uftc8inx 8081 30 GNR GNR NNP cord-010092-uftc8inx 8081 31 only only RB cord-010092-uftc8inx 8081 32 . . . cord-010092-uftc8inx 8082 1 Repeat repeat VB cord-010092-uftc8inx 8082 2 secondary secondary JJ cord-010092-uftc8inx 8082 3 safety safety NN cord-010092-uftc8inx 8082 4 measure measure NN cord-010092-uftc8inx 8083 1 PGD PGD NNP cord-010092-uftc8inx 8083 2 testing testing NN cord-010092-uftc8inx 8083 3 of of IN cord-010092-uftc8inx 8083 4 both both DT cord-010092-uftc8inx 8083 5 units unit NNS cord-010092-uftc8inx 8083 6 was be VBD cord-010092-uftc8inx 8083 7 negative negative JJ cord-010092-uftc8inx 8083 8 for for IN cord-010092-uftc8inx 8083 9 both both DT cord-010092-uftc8inx 8083 10 GP GP NNP cord-010092-uftc8inx 8083 11 and and CC cord-010092-uftc8inx 8083 12 GN GN NNP cord-010092-uftc8inx 8083 13 organisms organism NNS cord-010092-uftc8inx 8083 14 . . . cord-010092-uftc8inx 8084 1 Direct direct JJ cord-010092-uftc8inx 8084 2 bacterial bacterial JJ cord-010092-uftc8inx 8084 3 cultures culture NNS cord-010092-uftc8inx 8084 4 of of IN cord-010092-uftc8inx 8084 5 both both CC cord-010092-uftc8inx 8084 6 platelet platelet NN cord-010092-uftc8inx 8084 7 units unit NNS cord-010092-uftc8inx 8084 8 grew grow VBD cord-010092-uftc8inx 8084 9 both both DT cord-010092-uftc8inx 8084 10 GNR GNR NNP cord-010092-uftc8inx 8084 11 and and CC cord-010092-uftc8inx 8084 12 GPC GPC NNP cord-010092-uftc8inx 8084 13 identified identify VBD cord-010092-uftc8inx 8084 14 as as IN cord-010092-uftc8inx 8084 15 A. A. NNP cord-010092-uftc8inx 8084 16 baumanii baumanii NNP cord-010092-uftc8inx 8084 17 and and CC cord-010092-uftc8inx 8084 18 S. S. NNP cord-010092-uftc8inx 8084 19 saprophyticus saprophyticus NN cord-010092-uftc8inx 8084 20 after after IN cord-010092-uftc8inx 8084 21 18 18 CD cord-010092-uftc8inx 8084 22 h h NN cord-010092-uftc8inx 8084 23 of of IN cord-010092-uftc8inx 8084 24 incubation incubation NN cord-010092-uftc8inx 8084 25 . . . cord-010092-uftc8inx 8085 1 Colonies colony NNS cord-010092-uftc8inx 8085 2 on on IN cord-010092-uftc8inx 8085 3 the the DT cord-010092-uftc8inx 8085 4 initial initial JJ cord-010092-uftc8inx 8085 5 bacterial bacterial JJ cord-010092-uftc8inx 8085 6 plates plate NNS cord-010092-uftc8inx 8085 7 were be VBD cord-010092-uftc8inx 8085 8 too too RB cord-010092-uftc8inx 8085 9 numerous numerous JJ cord-010092-uftc8inx 8085 10 to to TO cord-010092-uftc8inx 8085 11 count count VB cord-010092-uftc8inx 8085 12 ( ( -LRB- cord-010092-uftc8inx 8085 13 TNTC TNTC NNP cord-010092-uftc8inx 8085 14 ) ) -RRB- cord-010092-uftc8inx 8085 15 , , , cord-010092-uftc8inx 8085 16 and and CC cord-010092-uftc8inx 8085 17 subsequent subsequent JJ cord-010092-uftc8inx 8085 18 re re NN cord-010092-uftc8inx 8085 19 - - NN cord-010092-uftc8inx 8085 20 plating plating NN cord-010092-uftc8inx 8085 21 of of IN cord-010092-uftc8inx 8085 22 the the DT cord-010092-uftc8inx 8085 23 platelet platelet NN cord-010092-uftc8inx 8085 24 units unit NNS cord-010092-uftc8inx 8085 25 showed show VBD cord-010092-uftc8inx 8085 26 : : : cord-010092-uftc8inx 8085 27 Unit unit NN cord-010092-uftc8inx 8085 28 1 1 CD cord-010092-uftc8inx 8085 29 : : : cord-010092-uftc8inx 8085 30 A. a. JJ cord-010092-uftc8inx 8085 31 baumanii baumanii NN cord-010092-uftc8inx 8085 32 TNTC TNTC NNP cord-010092-uftc8inx 8085 33 and and CC cord-010092-uftc8inx 8085 34 S. S. NNP cord-010092-uftc8inx 8085 35 saprophyticus saprophyticus NN cord-010092-uftc8inx 8085 36 with with IN cord-010092-uftc8inx 8085 37 8.5 8.5 CD cord-010092-uftc8inx 8085 38 9 9 CD cord-010092-uftc8inx 8085 39 10 10 CD cord-010092-uftc8inx 8085 40 4 4 CD cord-010092-uftc8inx 8085 41 CFU CFU NNP cord-010092-uftc8inx 8085 42 / / SYM cord-010092-uftc8inx 8085 43 mL mL NNP cord-010092-uftc8inx 8085 44 Unit unit NN cord-010092-uftc8inx 8085 45 2 2 CD cord-010092-uftc8inx 8086 1 : : : cord-010092-uftc8inx 8086 2 A. A. NNP cord-010092-uftc8inx 8086 3 baumanii baumanii NNP cord-010092-uftc8inx 8087 1 6.6 6.6 CD cord-010092-uftc8inx 8087 2 9 9 CD cord-010092-uftc8inx 8087 3 10 10 CD cord-010092-uftc8inx 8087 4 7 7 CD cord-010092-uftc8inx 8087 5 CFU CFU NNP cord-010092-uftc8inx 8087 6 / / SYM cord-010092-uftc8inx 8087 7 mL mL NNP cord-010092-uftc8inx 8087 8 and and CC cord-010092-uftc8inx 8087 9 S. S. NNP cord-010092-uftc8inx 8087 10 saprophyticus saprophyticus NNP cord-010092-uftc8inx 8087 11 2.2 2.2 CD cord-010092-uftc8inx 8087 12 9 9 CD cord-010092-uftc8inx 8087 13 10 10 CD cord-010092-uftc8inx 8087 14 6 6 CD cord-010092-uftc8inx 8088 1 CFU CFU NNP cord-010092-uftc8inx 8088 2 / / SYM cord-010092-uftc8inx 8088 3 mL mL NNP cord-010092-uftc8inx 8088 4 Blood blood NN cord-010092-uftc8inx 8088 5 cultures culture NNS cord-010092-uftc8inx 8088 6 collected collect VBN cord-010092-uftc8inx 8088 7 from from IN cord-010092-uftc8inx 8088 8 both both DT cord-010092-uftc8inx 8088 9 patients patient NNS cord-010092-uftc8inx 8088 10 became become VBD cord-010092-uftc8inx 8088 11 positive positive JJ cord-010092-uftc8inx 8088 12 within within IN cord-010092-uftc8inx 8088 13 8 8 CD cord-010092-uftc8inx 8088 14 h h NN cord-010092-uftc8inx 8088 15 with with IN cord-010092-uftc8inx 8088 16 GNR GNR NNP cord-010092-uftc8inx 8088 17 on on IN cord-010092-uftc8inx 8088 18 Gram Gram NNP cord-010092-uftc8inx 8088 19 stain stain NN cord-010092-uftc8inx 8088 20 , , , cord-010092-uftc8inx 8088 21 and and CC cord-010092-uftc8inx 8088 22 both both DT cord-010092-uftc8inx 8088 23 blood blood NN cord-010092-uftc8inx 8088 24 cultures culture NNS cord-010092-uftc8inx 8088 25 ultimately ultimately RB cord-010092-uftc8inx 8088 26 grew grow VBD cord-010092-uftc8inx 8088 27 both both DT cord-010092-uftc8inx 8088 28 A. a. JJ cord-010092-uftc8inx 8088 29 baumanii baumanii NN cord-010092-uftc8inx 8088 30 and and CC cord-010092-uftc8inx 8088 31 S. S. NNP cord-010092-uftc8inx 8088 32 saprophyticus saprophyticus NN cord-010092-uftc8inx 8088 33 . . . cord-010092-uftc8inx 8089 1 The the DT cord-010092-uftc8inx 8089 2 primary primary JJ cord-010092-uftc8inx 8089 3 pre pre JJ cord-010092-uftc8inx 8089 4 - - JJ cord-010092-uftc8inx 8089 5 release release JJ cord-010092-uftc8inx 8089 6 cultures culture NNS cord-010092-uftc8inx 8089 7 at at IN cord-010092-uftc8inx 8089 8 the the DT cord-010092-uftc8inx 8089 9 blood blood NN cord-010092-uftc8inx 8089 10 supplier supplier NN cord-010092-uftc8inx 8089 11 remained remain VBD cord-010092-uftc8inx 8089 12 negative negative JJ cord-010092-uftc8inx 8089 13 . . . cord-010092-uftc8inx 8090 1 After after IN cord-010092-uftc8inx 8090 2 days day NNS cord-010092-uftc8inx 8090 3 on on IN cord-010092-uftc8inx 8090 4 antibiotics antibiotic NNS cord-010092-uftc8inx 8090 5 and and CC cord-010092-uftc8inx 8090 6 pressors pressor NNS cord-010092-uftc8inx 8090 7 , , , cord-010092-uftc8inx 8090 8 both both DT cord-010092-uftc8inx 8090 9 patients patient NNS cord-010092-uftc8inx 8090 10 stabilized stabilize VBD cord-010092-uftc8inx 8090 11 and and CC cord-010092-uftc8inx 8090 12 were be VBD cord-010092-uftc8inx 8090 13 discharged discharge VBN cord-010092-uftc8inx 8090 14 home home RB cord-010092-uftc8inx 8090 15 . . . cord-010092-uftc8inx 8091 1 The the DT cord-010092-uftc8inx 8091 2 blood blood NN cord-010092-uftc8inx 8091 3 donor donor NN cord-010092-uftc8inx 8091 4 was be VBD cord-010092-uftc8inx 8091 5 interviewed interview VBN cord-010092-uftc8inx 8091 6 , , , cord-010092-uftc8inx 8091 7 and and CC cord-010092-uftc8inx 8091 8 he -PRON- PRP cord-010092-uftc8inx 8091 9 was be VBD cord-010092-uftc8inx 8091 10 well well JJ cord-010092-uftc8inx 8091 11 . . . cord-010092-uftc8inx 8092 1 No no DT cord-010092-uftc8inx 8092 2 cultures culture NNS cord-010092-uftc8inx 8092 3 were be VBD cord-010092-uftc8inx 8092 4 collected collect VBN cord-010092-uftc8inx 8092 5 . . . cord-010092-uftc8inx 8093 1 Summary Summary NNP cord-010092-uftc8inx 8093 2 / / SYM cord-010092-uftc8inx 8093 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 8093 4 : : : cord-010092-uftc8inx 8094 1 This this DT cord-010092-uftc8inx 8094 2 case case NN cord-010092-uftc8inx 8094 3 documents document VBZ cord-010092-uftc8inx 8094 4 failure failure NN cord-010092-uftc8inx 8094 5 of of IN cord-010092-uftc8inx 8094 6 both both DT cord-010092-uftc8inx 8094 7 primary primary JJ cord-010092-uftc8inx 8094 8 pre pre JJ cord-010092-uftc8inx 8094 9 - - JJ cord-010092-uftc8inx 8094 10 release release JJ cord-010092-uftc8inx 8094 11 bacterial bacterial JJ cord-010092-uftc8inx 8094 12 testing testing NN cord-010092-uftc8inx 8094 13 and and CC cord-010092-uftc8inx 8094 14 secondary secondary JJ cord-010092-uftc8inx 8094 15 on on IN cord-010092-uftc8inx 8094 16 - - HYPH cord-010092-uftc8inx 8094 17 site site NN cord-010092-uftc8inx 8094 18 point point NN cord-010092-uftc8inx 8094 19 of of IN cord-010092-uftc8inx 8094 20 release release NN cord-010092-uftc8inx 8094 21 PGD PGD NNP cord-010092-uftc8inx 8094 22 testing testing NN cord-010092-uftc8inx 8094 23 to to TO cord-010092-uftc8inx 8094 24 identify identify VB cord-010092-uftc8inx 8094 25 two two CD cord-010092-uftc8inx 8094 26 pathogenic pathogenic JJ cord-010092-uftc8inx 8094 27 organisms organism NNS cord-010092-uftc8inx 8094 28 . . . cord-010092-uftc8inx 8095 1 A. A. NNP cord-010092-uftc8inx 8095 2 baumanii baumanii NNP cord-010092-uftc8inx 8095 3 and and CC cord-010092-uftc8inx 8095 4 S. S. NNP cord-010092-uftc8inx 8095 5 saprophyticus saprophyticus NN cord-010092-uftc8inx 8095 6 are be VBP cord-010092-uftc8inx 8095 7 unusual unusual JJ cord-010092-uftc8inx 8095 8 causes cause NNS cord-010092-uftc8inx 8095 9 of of IN cord-010092-uftc8inx 8095 10 septic septic JJ cord-010092-uftc8inx 8095 11 transfusion transfusion NN cord-010092-uftc8inx 8095 12 reactions reaction NNS cord-010092-uftc8inx 8095 13 , , , cord-010092-uftc8inx 8095 14 and and CC cord-010092-uftc8inx 8095 15 it -PRON- PRP cord-010092-uftc8inx 8095 16 is be VBZ cord-010092-uftc8inx 8095 17 possible possible JJ cord-010092-uftc8inx 8095 18 that that IN cord-010092-uftc8inx 8095 19 these these DT cord-010092-uftc8inx 8095 20 organisms organism NNS cord-010092-uftc8inx 8095 21 have have VBP cord-010092-uftc8inx 8095 22 different different JJ cord-010092-uftc8inx 8095 23 limits limit NNS cord-010092-uftc8inx 8095 24 of of IN cord-010092-uftc8inx 8095 25 detection detection NN cord-010092-uftc8inx 8095 26 in in IN cord-010092-uftc8inx 8095 27 the the DT cord-010092-uftc8inx 8095 28 PGD PGD NNP cord-010092-uftc8inx 8095 29 assay assay NN cord-010092-uftc8inx 8095 30 compared compare VBN cord-010092-uftc8inx 8095 31 to to IN cord-010092-uftc8inx 8095 32 other other JJ cord-010092-uftc8inx 8095 33 organisms organism NNS cord-010092-uftc8inx 8095 34 . . . cord-010092-uftc8inx 8096 1 Rapid rapid JJ cord-010092-uftc8inx 8096 2 attention attention NN cord-010092-uftc8inx 8096 3 to to IN cord-010092-uftc8inx 8096 4 clinical clinical JJ cord-010092-uftc8inx 8096 5 signs sign NNS cord-010092-uftc8inx 8096 6 during during IN cord-010092-uftc8inx 8096 7 transfusion transfusion NN cord-010092-uftc8inx 8096 8 and and CC cord-010092-uftc8inx 8096 9 prompt prompt JJ cord-010092-uftc8inx 8096 10 initiation initiation NN cord-010092-uftc8inx 8096 11 of of IN cord-010092-uftc8inx 8096 12 antibiotics antibiotic NNS cord-010092-uftc8inx 8096 13 is be VBZ cord-010092-uftc8inx 8096 14 critical critical JJ cord-010092-uftc8inx 8096 15 for for IN cord-010092-uftc8inx 8096 16 the the DT cord-010092-uftc8inx 8096 17 management management NN cord-010092-uftc8inx 8096 18 of of IN cord-010092-uftc8inx 8096 19 septic septic JJ cord-010092-uftc8inx 8096 20 transfusion transfusion NN cord-010092-uftc8inx 8096 21 reactions reaction NNS cord-010092-uftc8inx 8096 22 . . . cord-010092-uftc8inx 8097 1 We -PRON- PRP cord-010092-uftc8inx 8097 2 are be VBP cord-010092-uftc8inx 8097 3 currently currently RB cord-010092-uftc8inx 8097 4 evaluating evaluate VBG cord-010092-uftc8inx 8097 5 ways way NNS cord-010092-uftc8inx 8097 6 to to TO cord-010092-uftc8inx 8097 7 further further RB cord-010092-uftc8inx 8097 8 reduce reduce VB cord-010092-uftc8inx 8097 9 septic septic JJ cord-010092-uftc8inx 8097 10 transfusion transfusion NN cord-010092-uftc8inx 8097 11 reactions reaction NNS cord-010092-uftc8inx 8097 12 , , , cord-010092-uftc8inx 8097 13 including include VBG cord-010092-uftc8inx 8097 14 increasing increase VBG cord-010092-uftc8inx 8097 15 the the DT cord-010092-uftc8inx 8097 16 utilization utilization NN cord-010092-uftc8inx 8097 17 of of IN cord-010092-uftc8inx 8097 18 pathogen pathogen NN cord-010092-uftc8inx 8097 19 reduced reduce VBN cord-010092-uftc8inx 8097 20 platelets platelet NNS cord-010092-uftc8inx 8097 21 . . . cord-010092-uftc8inx 8098 1 Background background NN cord-010092-uftc8inx 8098 2 : : : cord-010092-uftc8inx 8099 1 Transfusion transfusion NN cord-010092-uftc8inx 8099 2 - - HYPH cord-010092-uftc8inx 8099 3 associated associate VBN cord-010092-uftc8inx 8099 4 infections infection NNS cord-010092-uftc8inx 8099 5 due due JJ cord-010092-uftc8inx 8099 6 to to IN cord-010092-uftc8inx 8099 7 the the DT cord-010092-uftc8inx 8099 8 transmission transmission NN cord-010092-uftc8inx 8099 9 of of IN cord-010092-uftc8inx 8099 10 bacteria bacteria NNS cord-010092-uftc8inx 8099 11 still still RB cord-010092-uftc8inx 8099 12 represents represent VBZ cord-010092-uftc8inx 8099 13 a a DT cord-010092-uftc8inx 8099 14 major major JJ cord-010092-uftc8inx 8099 15 risk risk NN cord-010092-uftc8inx 8099 16 in in IN cord-010092-uftc8inx 8099 17 developed develop VBN cord-010092-uftc8inx 8099 18 countries country NNS cord-010092-uftc8inx 8099 19 nowadays nowadays RB cord-010092-uftc8inx 8099 20 . . . cord-010092-uftc8inx 8100 1 Despite despite IN cord-010092-uftc8inx 8100 2 the the DT cord-010092-uftc8inx 8100 3 refrigerated refrigerated JJ cord-010092-uftc8inx 8100 4 storage storage NN cord-010092-uftc8inx 8100 5 of of IN cord-010092-uftc8inx 8100 6 red red JJ cord-010092-uftc8inx 8100 7 blood blood NN cord-010092-uftc8inx 8100 8 cells cell NNS cord-010092-uftc8inx 8100 9 ( ( -LRB- cord-010092-uftc8inx 8100 10 RBC RBC NNP cord-010092-uftc8inx 8100 11 ) ) -RRB- cord-010092-uftc8inx 8100 12 , , , cord-010092-uftc8inx 8100 13 fatal fatal JJ cord-010092-uftc8inx 8100 14 reactions reaction NNS cord-010092-uftc8inx 8100 15 of of IN cord-010092-uftc8inx 8100 16 patients patient NNS cord-010092-uftc8inx 8100 17 receiving receive VBG cord-010092-uftc8inx 8100 18 contaminated contaminate VBN cord-010092-uftc8inx 8100 19 RBC RBC NNP cord-010092-uftc8inx 8100 20 units unit NNS cord-010092-uftc8inx 8100 21 are be VBP cord-010092-uftc8inx 8100 22 repeatedly repeatedly RB cord-010092-uftc8inx 8100 23 reported report VBN cord-010092-uftc8inx 8100 24 . . . cord-010092-uftc8inx 8101 1 In in IN cord-010092-uftc8inx 8101 2 order order NN cord-010092-uftc8inx 8101 3 to to TO cord-010092-uftc8inx 8101 4 further further RB cord-010092-uftc8inx 8101 5 increase increase VB cord-010092-uftc8inx 8101 6 the the DT cord-010092-uftc8inx 8101 7 safety safety NN cord-010092-uftc8inx 8101 8 of of IN cord-010092-uftc8inx 8101 9 blood blood NN cord-010092-uftc8inx 8101 10 transfusions transfusion NNS cord-010092-uftc8inx 8101 11 , , , cord-010092-uftc8inx 8101 12 new new JJ cord-010092-uftc8inx 8101 13 strategies strategy NNS cord-010092-uftc8inx 8101 14 and and CC cord-010092-uftc8inx 8101 15 measures measure NNS cord-010092-uftc8inx 8101 16 have have VBP cord-010092-uftc8inx 8101 17 to to TO cord-010092-uftc8inx 8101 18 be be VB cord-010092-uftc8inx 8101 19 developed develop VBN cord-010092-uftc8inx 8101 20 . . . cord-010092-uftc8inx 8102 1 In in IN cord-010092-uftc8inx 8102 2 this this DT cord-010092-uftc8inx 8102 3 context context NN cord-010092-uftc8inx 8102 4 , , , cord-010092-uftc8inx 8102 5 Transfusion transfusion NN cord-010092-uftc8inx 8102 6 - - HYPH cord-010092-uftc8inx 8102 7 Relevant Relevant NNP cord-010092-uftc8inx 8102 8 Bacteria Bacteria NNPS cord-010092-uftc8inx 8102 9 Reference reference NN cord-010092-uftc8inx 8102 10 Strains strain NNS cord-010092-uftc8inx 8102 11 can can MD cord-010092-uftc8inx 8102 12 serve serve VB cord-010092-uftc8inx 8102 13 as as IN cord-010092-uftc8inx 8102 14 a a DT cord-010092-uftc8inx 8102 15 valuable valuable JJ cord-010092-uftc8inx 8102 16 tool tool NN cord-010092-uftc8inx 8102 17 for for IN cord-010092-uftc8inx 8102 18 the the DT cord-010092-uftc8inx 8102 19 validation validation NN cord-010092-uftc8inx 8102 20 , , , cord-010092-uftc8inx 8102 21 comparison comparison NN cord-010092-uftc8inx 8102 22 and and CC cord-010092-uftc8inx 8102 23 interpretation interpretation NN cord-010092-uftc8inx 8102 24 of of IN cord-010092-uftc8inx 8102 25 these these DT cord-010092-uftc8inx 8102 26 new new JJ cord-010092-uftc8inx 8102 27 developments development NNS cord-010092-uftc8inx 8102 28 . . . cord-010092-uftc8inx 8103 1 Aims aim VBZ cord-010092-uftc8inx 8103 2 : : : cord-010092-uftc8inx 8103 3 Conducting conduct VBG cord-010092-uftc8inx 8103 4 a a DT cord-010092-uftc8inx 8103 5 collaborative collaborative JJ cord-010092-uftc8inx 8103 6 study study NN cord-010092-uftc8inx 8103 7 to to TO cord-010092-uftc8inx 8103 8 establish establish VB cord-010092-uftc8inx 8103 9 the the DT cord-010092-uftc8inx 8103 10 first first JJ cord-010092-uftc8inx 8103 11 repository repository NN cord-010092-uftc8inx 8103 12 for for IN cord-010092-uftc8inx 8103 13 red red JJ cord-010092-uftc8inx 8103 14 blood blood NN cord-010092-uftc8inx 8103 15 cell cell NN cord-010092-uftc8inx 8103 16 Transfusion transfusion NN cord-010092-uftc8inx 8103 17 - - HYPH cord-010092-uftc8inx 8103 18 Relevant Relevant NNP cord-010092-uftc8inx 8103 19 Bacteria Bacteria NNPS cord-010092-uftc8inx 8103 20 Reference reference NN cord-010092-uftc8inx 8103 21 Strains strain NNS cord-010092-uftc8inx 8103 22 . . . cord-010092-uftc8inx 8104 1 Methods method NNS cord-010092-uftc8inx 8104 2 : : : cord-010092-uftc8inx 8105 1 Six six CD cord-010092-uftc8inx 8105 2 bacterial bacterial JJ cord-010092-uftc8inx 8105 3 strains strain NNS cord-010092-uftc8inx 8105 4 ( ( -LRB- cord-010092-uftc8inx 8105 5 Serratia Serratia NNP cord-010092-uftc8inx 8105 6 liquefaciens liquefacien NNS cord-010092-uftc8inx 8105 7 , , , cord-010092-uftc8inx 8105 8 Serratia Serratia NNP cord-010092-uftc8inx 8105 9 marcescens marcescen NNS cord-010092-uftc8inx 8105 10 , , , cord-010092-uftc8inx 8105 11 Pseudomonas Pseudomonas NNP cord-010092-uftc8inx 8105 12 fluorescens fluorescen NNS cord-010092-uftc8inx 8105 13 , , , cord-010092-uftc8inx 8105 14 Listeria Listeria NNP cord-010092-uftc8inx 8105 15 monocytogenes monocytogenes NNP cord-010092-uftc8inx 8105 16 , , , cord-010092-uftc8inx 8105 17 Yersinia Yersinia NNP cord-010092-uftc8inx 8105 18 enterocolitica enterocolitica NNP cord-010092-uftc8inx 8106 1 A-105 A-105 NNP cord-010092-uftc8inx 8106 2 and and CC cord-010092-uftc8inx 8106 3 Yersinia Yersinia NNP cord-010092-uftc8inx 8106 4 enterocolitica enterocolitica NNP cord-010092-uftc8inx 8106 5 A-176 A-176 MD cord-010092-uftc8inx 8106 6 ) ) -RRB- cord-010092-uftc8inx 8106 7 were be VBD cord-010092-uftc8inx 8106 8 distributed distribute VBN cord-010092-uftc8inx 8106 9 from from IN cord-010092-uftc8inx 8106 10 the the DT cord-010092-uftc8inx 8106 11 Paul Paul NNP cord-010092-uftc8inx 8106 12 - - HYPH cord-010092-uftc8inx 8106 13 Ehrlich Ehrlich NNP cord-010092-uftc8inx 8106 14 - - HYPH cord-010092-uftc8inx 8106 15 Institut Institut NNP cord-010092-uftc8inx 8106 16 to to IN cord-010092-uftc8inx 8106 17 17 17 CD cord-010092-uftc8inx 8106 18 laboratories laboratory NNS cord-010092-uftc8inx 8106 19 in in IN cord-010092-uftc8inx 8106 20 10 10 CD cord-010092-uftc8inx 8106 21 countries country NNS cord-010092-uftc8inx 8106 22 for for IN cord-010092-uftc8inx 8106 23 enumeration enumeration NN cord-010092-uftc8inx 8106 24 , , , cord-010092-uftc8inx 8106 25 identification identification NN cord-010092-uftc8inx 8106 26 and and CC cord-010092-uftc8inx 8106 27 growth growth NN cord-010092-uftc8inx 8106 28 measurement measurement NN cord-010092-uftc8inx 8106 29 in in IN cord-010092-uftc8inx 8106 30 a a DT cord-010092-uftc8inx 8106 31 7-day 7-day JJ cord-010092-uftc8inx 8106 32 interval interval NN cord-010092-uftc8inx 8106 33 for for IN cord-010092-uftc8inx 8106 34 a a DT cord-010092-uftc8inx 8106 35 total total NN cord-010092-uftc8inx 8106 36 of of IN cord-010092-uftc8inx 8106 37 42 42 CD cord-010092-uftc8inx 8106 38 days day NNS cord-010092-uftc8inx 8106 39 after after IN cord-010092-uftc8inx 8106 40 low low JJ cord-010092-uftc8inx 8106 41 - - HYPH cord-010092-uftc8inx 8106 42 count count NN cord-010092-uftc8inx 8106 43 spiking spiking NN cord-010092-uftc8inx 8106 44 of of IN cord-010092-uftc8inx 8106 45 RBC RBC NNP cord-010092-uftc8inx 8106 46 bags bag NNS cord-010092-uftc8inx 8106 47 ( ( -LRB- cord-010092-uftc8inx 8106 48 10 10 CD cord-010092-uftc8inx 8106 49 - - SYM cord-010092-uftc8inx 8106 50 25 25 CD cord-010092-uftc8inx 8106 51 colony colony NN cord-010092-uftc8inx 8106 52 - - HYPH cord-010092-uftc8inx 8106 53 forming form VBG cord-010092-uftc8inx 8106 54 units unit NNS cord-010092-uftc8inx 8106 55 ( ( -LRB- cord-010092-uftc8inx 8106 56 CFU)/RBC CFU)/RBC NNP cord-010092-uftc8inx 8106 57 bag bag NN cord-010092-uftc8inx 8106 58 ) ) -RRB- cord-010092-uftc8inx 8106 59 . . . cord-010092-uftc8inx 8107 1 Results result NNS cord-010092-uftc8inx 8107 2 : : : cord-010092-uftc8inx 8108 1 Except except IN cord-010092-uftc8inx 8108 2 for for IN cord-010092-uftc8inx 8108 3 S. S. NNP cord-010092-uftc8inx 8108 4 marcescens marcescen NNS cord-010092-uftc8inx 8108 5 , , , cord-010092-uftc8inx 8108 6 all all DT cord-010092-uftc8inx 8108 7 other other JJ cord-010092-uftc8inx 8108 8 strains strain NNS cord-010092-uftc8inx 8108 9 showed show VBD cord-010092-uftc8inx 8108 10 good good JJ cord-010092-uftc8inx 8108 11 - - HYPH cord-010092-uftc8inx 8108 12 to to IN cord-010092-uftc8inx 8108 13 - - HYPH cord-010092-uftc8inx 8108 14 excellent excellent JJ cord-010092-uftc8inx 8108 15 growth growth NN cord-010092-uftc8inx 8108 16 in in IN cord-010092-uftc8inx 8108 17 RBC RBC NNP cord-010092-uftc8inx 8108 18 . . . cord-010092-uftc8inx 8109 1 S. S. NNP cord-010092-uftc8inx 8109 2 liquefaciens liquefaciens NNP cord-010092-uftc8inx 8109 3 , , , cord-010092-uftc8inx 8109 4 P. P. NNP cord-010092-uftc8inx 8109 5 fluorescens fluorescens NNP cord-010092-uftc8inx 8109 6 , , , cord-010092-uftc8inx 8109 7 Y. Y. NNP cord-010092-uftc8inx 8109 8 enterocolitica enterocolitica NNP cord-010092-uftc8inx 8109 9 A-105 A-105 NNP cord-010092-uftc8inx 8109 10 and and CC cord-010092-uftc8inx 8109 11 Y. Y. NNP cord-010092-uftc8inx 8109 12 enterocolitica enterocolitica NNP cord-010092-uftc8inx 8110 1 A-176 A-176 NNP cord-010092-uftc8inx 8110 2 achieved achieve VBN cord-010092-uftc8inx 8110 3 > > XX cord-010092-uftc8inx 8110 4 10 10 CD cord-010092-uftc8inx 8110 5 6 6 CD cord-010092-uftc8inx 8110 6 CFU CFU NNP cord-010092-uftc8inx 8110 7 / / SYM cord-010092-uftc8inx 8110 8 ml ml NN cord-010092-uftc8inx 8110 9 at at IN cord-010092-uftc8inx 8110 10 day day NN cord-010092-uftc8inx 8110 11 14 14 CD cord-010092-uftc8inx 8110 12 and and CC cord-010092-uftc8inx 8110 13 10 10 CD cord-010092-uftc8inx 8110 14 9 9 CD cord-010092-uftc8inx 8110 15 CFU CFU NNP cord-010092-uftc8inx 8110 16 / / SYM cord-010092-uftc8inx 8110 17 ml ml NN cord-010092-uftc8inx 8110 18 at at IN cord-010092-uftc8inx 8110 19 day day NN cord-010092-uftc8inx 8110 20 21 21 CD cord-010092-uftc8inx 8110 21 . . . cord-010092-uftc8inx 8111 1 Growth growth NN cord-010092-uftc8inx 8111 2 of of IN cord-010092-uftc8inx 8111 3 L. L. NNP cord-010092-uftc8inx 8111 4 monocytogenes monocytogene NNS cord-010092-uftc8inx 8111 5 was be VBD cord-010092-uftc8inx 8111 6 lower low JJR cord-010092-uftc8inx 8111 7 reaching reach VBG cord-010092-uftc8inx 8111 8 a a DT cord-010092-uftc8inx 8111 9 maximum maximum JJ cord-010092-uftc8inx 8111 10 concentration concentration NN cord-010092-uftc8inx 8111 11 of of IN cord-010092-uftc8inx 8111 12 > > XX cord-010092-uftc8inx 8111 13 10 10 CD cord-010092-uftc8inx 8111 14 6 6 CD cord-010092-uftc8inx 8111 15 CFU CFU NNP cord-010092-uftc8inx 8111 16 / / SYM cord-010092-uftc8inx 8111 17 ml ml NN cord-010092-uftc8inx 8111 18 at at IN cord-010092-uftc8inx 8111 19 day day NN cord-010092-uftc8inx 8111 20 35 35 CD cord-010092-uftc8inx 8111 21 . . . cord-010092-uftc8inx 8112 1 In in IN cord-010092-uftc8inx 8112 2 9 9 CD cord-010092-uftc8inx 8112 3 out out IN cord-010092-uftc8inx 8112 4 of of IN cord-010092-uftc8inx 8112 5 17 17 CD cord-010092-uftc8inx 8112 6 laboratories laboratory NNS cord-010092-uftc8inx 8112 7 , , , cord-010092-uftc8inx 8112 8 S. S. NNP cord-010092-uftc8inx 8112 9 marcescens marcescens NNP cord-010092-uftc8inx 8112 10 showed show VBD cord-010092-uftc8inx 8112 11 no no DT cord-010092-uftc8inx 8112 12 growth growth NN cord-010092-uftc8inx 8112 13 at at RB cord-010092-uftc8inx 8112 14 all all RB cord-010092-uftc8inx 8112 15 . . . cord-010092-uftc8inx 8113 1 Summary Summary NNP cord-010092-uftc8inx 8113 2 / / SYM cord-010092-uftc8inx 8113 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 8113 4 : : : cord-010092-uftc8inx 8114 1 Five five CD cord-010092-uftc8inx 8114 2 of of IN cord-010092-uftc8inx 8114 3 the the DT cord-010092-uftc8inx 8114 4 six six CD cord-010092-uftc8inx 8114 5 tested test VBN cord-010092-uftc8inx 8114 6 strains strain NNS cord-010092-uftc8inx 8114 7 showed show VBD cord-010092-uftc8inx 8114 8 robust robust JJ cord-010092-uftc8inx 8114 9 growth growth NN cord-010092-uftc8inx 8114 10 in in IN cord-010092-uftc8inx 8114 11 RBC RBC NNP cord-010092-uftc8inx 8114 12 independent independent JJ cord-010092-uftc8inx 8114 13 of of IN cord-010092-uftc8inx 8114 14 donor donor NN cord-010092-uftc8inx 8114 15 variability variability NN cord-010092-uftc8inx 8114 16 and and CC cord-010092-uftc8inx 8114 17 are be VBP cord-010092-uftc8inx 8114 18 promising promising JJ cord-010092-uftc8inx 8114 19 candidates candidate NNS cord-010092-uftc8inx 8114 20 to to TO cord-010092-uftc8inx 8114 21 be be VB cord-010092-uftc8inx 8114 22 adopted adopt VBN cord-010092-uftc8inx 8114 23 as as IN cord-010092-uftc8inx 8114 24 official official JJ cord-010092-uftc8inx 8114 25 RBC RBC NNP cord-010092-uftc8inx 8114 26 Transfusion Transfusion NNP cord-010092-uftc8inx 8114 27 - - HYPH cord-010092-uftc8inx 8114 28 Relevant Relevant NNP cord-010092-uftc8inx 8114 29 Reference reference NN cord-010092-uftc8inx 8114 30 Strains strain NNS cord-010092-uftc8inx 8114 31 by by IN cord-010092-uftc8inx 8114 32 the the DT cord-010092-uftc8inx 8114 33 World World NNP cord-010092-uftc8inx 8114 34 Health Health NNP cord-010092-uftc8inx 8114 35 Organization Organization NNP cord-010092-uftc8inx 8114 36 . . . cord-010092-uftc8inx 8114 37 _SP cord-010092-uftc8inx 8115 1 Background background NN cord-010092-uftc8inx 8115 2 : : : cord-010092-uftc8inx 8116 1 The the DT cord-010092-uftc8inx 8116 2 SampLok SampLok NNP cord-010092-uftc8inx 8116 3 Sampling Sampling NNP cord-010092-uftc8inx 8116 4 Kit kit NN cord-010092-uftc8inx 8116 5 ( ( -LRB- cord-010092-uftc8inx 8116 6 SSK SSK NNP cord-010092-uftc8inx 8116 7 ) ) -RRB- cord-010092-uftc8inx 8116 8 , , , cord-010092-uftc8inx 8116 9 ITL ITL NNP cord-010092-uftc8inx 8116 10 BioMedical BioMedical NNP cord-010092-uftc8inx 8116 11 , , , cord-010092-uftc8inx 8116 12 is be VBZ cord-010092-uftc8inx 8116 13 used use VBN cord-010092-uftc8inx 8116 14 by by IN cord-010092-uftc8inx 8116 15 NHS NHS NNP cord-010092-uftc8inx 8116 16 Blood Blood NNP cord-010092-uftc8inx 8116 17 and and CC cord-010092-uftc8inx 8116 18 Transplant Transplant NNP cord-010092-uftc8inx 8116 19 ( ( -LRB- cord-010092-uftc8inx 8116 20 NHSBT NHSBT NNP cord-010092-uftc8inx 8116 21 ) ) -RRB- cord-010092-uftc8inx 8116 22 for for IN cord-010092-uftc8inx 8116 23 sampling sampling NN cord-010092-uftc8inx 8116 24 of of IN cord-010092-uftc8inx 8116 25 platelet platelet NN cord-010092-uftc8inx 8116 26 components component NNS cord-010092-uftc8inx 8116 27 ( ( -LRB- cord-010092-uftc8inx 8116 28 PC pc NN cord-010092-uftc8inx 8116 29 ) ) -RRB- cord-010092-uftc8inx 8116 30 for for IN cord-010092-uftc8inx 8116 31 bacterial bacterial JJ cord-010092-uftc8inx 8116 32 screening screening NN cord-010092-uftc8inx 8116 33 using use VBG cord-010092-uftc8inx 8116 34 the the DT cord-010092-uftc8inx 8116 35 BacT BacT NNP cord-010092-uftc8inx 8116 36 / / SYM cord-010092-uftc8inx 8116 37 ALERT ALERT NNP cord-010092-uftc8inx 8116 38 3D 3d JJ cord-010092-uftc8inx 8116 39 system system NN cord-010092-uftc8inx 8116 40 . . . cord-010092-uftc8inx 8117 1 Inoculation inoculation NN cord-010092-uftc8inx 8117 2 of of IN cord-010092-uftc8inx 8117 3 BacT BacT NNP cord-010092-uftc8inx 8117 4 / / SYM cord-010092-uftc8inx 8117 5 ALERT ALERT NNP cord-010092-uftc8inx 8117 6 bottles bottle NNS cord-010092-uftc8inx 8117 7 is be VBZ cord-010092-uftc8inx 8117 8 performed perform VBN cord-010092-uftc8inx 8117 9 immediately immediately RB cord-010092-uftc8inx 8117 10 after after IN cord-010092-uftc8inx 8117 11 sampling sampling NN cord-010092-uftc8inx 8117 12 . . . cord-010092-uftc8inx 8118 1 Validation validation NN cord-010092-uftc8inx 8118 2 of of IN cord-010092-uftc8inx 8118 3 delayed delay VBN cord-010092-uftc8inx 8118 4 inoculation inoculation NN cord-010092-uftc8inx 8118 5 , , , cord-010092-uftc8inx 8118 6 with with IN cord-010092-uftc8inx 8118 7 retention retention NN cord-010092-uftc8inx 8118 8 of of IN cord-010092-uftc8inx 8118 9 the the DT cord-010092-uftc8inx 8118 10 sample sample NN cord-010092-uftc8inx 8118 11 within within IN cord-010092-uftc8inx 8118 12 the the DT cord-010092-uftc8inx 8118 13 SSK SSK NNP cord-010092-uftc8inx 8118 14 devices device NNS cord-010092-uftc8inx 8118 15 , , , cord-010092-uftc8inx 8118 16 would would MD cord-010092-uftc8inx 8118 17 allow allow VB cord-010092-uftc8inx 8118 18 a a DT cord-010092-uftc8inx 8118 19 contingency contingency NN cord-010092-uftc8inx 8118 20 for for IN cord-010092-uftc8inx 8118 21 transport transport NN cord-010092-uftc8inx 8118 22 to to IN cord-010092-uftc8inx 8118 23 other other JJ cord-010092-uftc8inx 8118 24 screening screening NN cord-010092-uftc8inx 8118 25 sites site NNS cord-010092-uftc8inx 8118 26 in in IN cord-010092-uftc8inx 8118 27 the the DT cord-010092-uftc8inx 8118 28 event event NN cord-010092-uftc8inx 8118 29 of of IN cord-010092-uftc8inx 8118 30 an an DT cord-010092-uftc8inx 8118 31 incident incident NN cord-010092-uftc8inx 8118 32 that that WDT cord-010092-uftc8inx 8118 33 prevented prevent VBD cord-010092-uftc8inx 8118 34 testing testing NN cord-010092-uftc8inx 8118 35 at at IN cord-010092-uftc8inx 8118 36 the the DT cord-010092-uftc8inx 8118 37 sampling sampling NN cord-010092-uftc8inx 8118 38 site site NN cord-010092-uftc8inx 8118 39 . . . cord-010092-uftc8inx 8119 1 SSK SSK NNP cord-010092-uftc8inx 8119 2 maintain maintain VBP cord-010092-uftc8inx 8119 3 a a DT cord-010092-uftc8inx 8119 4 closed closed JJ cord-010092-uftc8inx 8119 5 system system NN cord-010092-uftc8inx 8119 6 for for IN cord-010092-uftc8inx 8119 7 sampling sampling NN cord-010092-uftc8inx 8119 8 of of IN cord-010092-uftc8inx 8119 9 PC pc NN cord-010092-uftc8inx 8119 10 and and CC cord-010092-uftc8inx 8119 11 are be VBP cord-010092-uftc8inx 8119 12 compatible compatible JJ cord-010092-uftc8inx 8119 13 with with IN cord-010092-uftc8inx 8119 14 standard standard JJ cord-010092-uftc8inx 8119 15 blood blood NN cord-010092-uftc8inx 8119 16 collection collection NN cord-010092-uftc8inx 8119 17 bags bag NNS cord-010092-uftc8inx 8119 18 . . . cord-010092-uftc8inx 8120 1 A a DT cord-010092-uftc8inx 8120 2 graduated graduate VBN cord-010092-uftc8inx 8120 3 chamber chamber NN cord-010092-uftc8inx 8120 4 ( ( -LRB- cord-010092-uftc8inx 8120 5 10 10 CD cord-010092-uftc8inx 8120 6 or or CC cord-010092-uftc8inx 8120 7 16 16 CD cord-010092-uftc8inx 8120 8 ml ml NNS cord-010092-uftc8inx 8120 9 ) ) -RRB- cord-010092-uftc8inx 8120 10 ensures ensure VBZ cord-010092-uftc8inx 8120 11 that that IN cord-010092-uftc8inx 8120 12 only only RB cord-010092-uftc8inx 8120 13 the the DT cord-010092-uftc8inx 8120 14 required require VBN cord-010092-uftc8inx 8120 15 sample sample NN cord-010092-uftc8inx 8120 16 volume volume NN cord-010092-uftc8inx 8120 17 is be VBZ cord-010092-uftc8inx 8120 18 collected collect VBN cord-010092-uftc8inx 8120 19 and and CC cord-010092-uftc8inx 8120 20 an an DT cord-010092-uftc8inx 8120 21 integrated integrated JJ cord-010092-uftc8inx 8120 22 needle needle NN cord-010092-uftc8inx 8120 23 allows allow VBZ cord-010092-uftc8inx 8120 24 inoculation inoculation NN cord-010092-uftc8inx 8120 25 into into IN cord-010092-uftc8inx 8120 26 BacT BacT NNP cord-010092-uftc8inx 8120 27 / / SYM cord-010092-uftc8inx 8120 28 ALERT alert NN cord-010092-uftc8inx 8120 29 bottles bottle NNS cord-010092-uftc8inx 8120 30 . . . cord-010092-uftc8inx 8121 1 Aims aim VBZ cord-010092-uftc8inx 8121 2 : : : cord-010092-uftc8inx 8122 1 The the DT cord-010092-uftc8inx 8122 2 National National NNP cord-010092-uftc8inx 8122 3 Bacteriology Bacteriology NNP cord-010092-uftc8inx 8122 4 Laboratory Laboratory NNP cord-010092-uftc8inx 8122 5 , , , cord-010092-uftc8inx 8122 6 NHSBT NHSBT NNP cord-010092-uftc8inx 8122 7 , , , cord-010092-uftc8inx 8122 8 evaluated evaluate VBD cord-010092-uftc8inx 8122 9 the the DT cord-010092-uftc8inx 8122 10 impact impact NN cord-010092-uftc8inx 8122 11 of of IN cord-010092-uftc8inx 8122 12 prolonged prolonged JJ cord-010092-uftc8inx 8122 13 storage storage NN cord-010092-uftc8inx 8122 14 of of IN cord-010092-uftc8inx 8122 15 PC pc NN cord-010092-uftc8inx 8122 16 samples sample NNS cord-010092-uftc8inx 8122 17 in in IN cord-010092-uftc8inx 8122 18 SSK SSK NNP cord-010092-uftc8inx 8122 19 devices device NNS cord-010092-uftc8inx 8122 20 with with IN cord-010092-uftc8inx 8122 21 regard regard NN cord-010092-uftc8inx 8122 22 to to IN cord-010092-uftc8inx 8122 23 bacterial bacterial JJ cord-010092-uftc8inx 8122 24 viability viability NN cord-010092-uftc8inx 8122 25 and and CC cord-010092-uftc8inx 8122 26 detection detection NN cord-010092-uftc8inx 8122 27 . . . cord-010092-uftc8inx 8123 1 Methods method NNS cord-010092-uftc8inx 8123 2 : : : cord-010092-uftc8inx 8123 3 Four four CD cord-010092-uftc8inx 8123 4 reference reference NN cord-010092-uftc8inx 8123 5 species specie NNS cord-010092-uftc8inx 8123 6 were be VBD cord-010092-uftc8inx 8123 7 assessed assess VBN cord-010092-uftc8inx 8123 8 : : : cord-010092-uftc8inx 8123 9 Staphylococcus Staphylococcus NNP cord-010092-uftc8inx 8123 10 aureus aureus NN cord-010092-uftc8inx 8123 11 ( ( -LRB- cord-010092-uftc8inx 8123 12 ATCC ATCC NNP cord-010092-uftc8inx 8123 13 29523 29523 CD cord-010092-uftc8inx 8123 14 ) ) -RRB- cord-010092-uftc8inx 8123 15 , , , cord-010092-uftc8inx 8123 16 Streptococcus Streptococcus NNP cord-010092-uftc8inx 8123 17 agalactiae agalactiae NNP cord-010092-uftc8inx 8123 18 ( ( -LRB- cord-010092-uftc8inx 8123 19 ATCC ATCC NNP cord-010092-uftc8inx 8123 20 13813 13813 CD cord-010092-uftc8inx 8123 21 ) ) -RRB- cord-010092-uftc8inx 8123 22 , , , cord-010092-uftc8inx 8123 23 Escherichia Escherichia NNP cord-010092-uftc8inx 8123 24 coli coli NNS cord-010092-uftc8inx 8123 25 ( ( -LRB- cord-010092-uftc8inx 8123 26 ATCC ATCC NNP cord-010092-uftc8inx 8123 27 25922 25922 CD cord-010092-uftc8inx 8123 28 ) ) -RRB- cord-010092-uftc8inx 8123 29 , , , cord-010092-uftc8inx 8123 30 Clostridium clostridium NN cord-010092-uftc8inx 8123 31 perfringens perfringen NNS cord-010092-uftc8inx 8123 32 ( ( -LRB- cord-010092-uftc8inx 8123 33 ATCC ATCC NNP cord-010092-uftc8inx 8123 34 13124 13124 CD cord-010092-uftc8inx 8123 35 ) ) -RRB- cord-010092-uftc8inx 8123 36 . . . cord-010092-uftc8inx 8124 1 A a DT cord-010092-uftc8inx 8124 2 pool pool NN cord-010092-uftc8inx 8124 3 and and CC cord-010092-uftc8inx 8124 4 split split NN cord-010092-uftc8inx 8124 5 method method NN cord-010092-uftc8inx 8124 6 was be VBD cord-010092-uftc8inx 8124 7 used use VBN cord-010092-uftc8inx 8124 8 with with IN cord-010092-uftc8inx 8124 9 apheresis apheresis NN cord-010092-uftc8inx 8124 10 PC pc NN cord-010092-uftc8inx 8124 11 suspended suspend VBN cord-010092-uftc8inx 8124 12 in in IN cord-010092-uftc8inx 8124 13 plasma plasma NN cord-010092-uftc8inx 8124 14 . . . cord-010092-uftc8inx 8125 1 Units unit NNS cord-010092-uftc8inx 8125 2 were be VBD cord-010092-uftc8inx 8125 3 screened screen VBN cord-010092-uftc8inx 8125 4 using use VBG cord-010092-uftc8inx 8125 5 BacT BacT NNP cord-010092-uftc8inx 8125 6 / / SYM cord-010092-uftc8inx 8125 7 ALERT ALERT NNP cord-010092-uftc8inx 8125 8 3D 3d NN cord-010092-uftc8inx 8125 9 prior prior RB cord-010092-uftc8inx 8125 10 to to IN cord-010092-uftc8inx 8125 11 spiking spike VBG cord-010092-uftc8inx 8125 12 to to TO cord-010092-uftc8inx 8125 13 prove prove VB cord-010092-uftc8inx 8125 14 the the DT cord-010092-uftc8inx 8125 15 absence absence NN cord-010092-uftc8inx 8125 16 of of IN cord-010092-uftc8inx 8125 17 contamination contamination NN cord-010092-uftc8inx 8125 18 . . . cord-010092-uftc8inx 8126 1 PC pc NN cord-010092-uftc8inx 8126 2 were be VBD cord-010092-uftc8inx 8126 3 spiked spike VBN cord-010092-uftc8inx 8126 4 with with IN cord-010092-uftc8inx 8126 5 a a DT cord-010092-uftc8inx 8126 6 single single JJ cord-010092-uftc8inx 8126 7 species specie NNS cord-010092-uftc8inx 8126 8 ( ( -LRB- cord-010092-uftc8inx 8126 9 range range NN cord-010092-uftc8inx 8126 10 4 4 CD cord-010092-uftc8inx 8126 11 9 9 CD cord-010092-uftc8inx 8126 12 100 100 CD cord-010092-uftc8inx 8126 13 - - SYM cord-010092-uftc8inx 8126 14 2.8 2.8 CD cord-010092-uftc8inx 8126 15 9 9 CD cord-010092-uftc8inx 8126 16 103 103 CD cord-010092-uftc8inx 8126 17 CFU CFU NNP cord-010092-uftc8inx 8126 18 / / SYM cord-010092-uftc8inx 8126 19 ml ml NN cord-010092-uftc8inx 8126 20 ) ) -RRB- cord-010092-uftc8inx 8126 21 and and CC cord-010092-uftc8inx 8126 22 tested test VBN cord-010092-uftc8inx 8126 23 on on IN cord-010092-uftc8inx 8126 24 BacT BacT NNP cord-010092-uftc8inx 8126 25 / / SYM cord-010092-uftc8inx 8126 26 ALERT ALERT NNP cord-010092-uftc8inx 8126 27 with with IN cord-010092-uftc8inx 8126 28 a a DT cord-010092-uftc8inx 8126 29 1 1 CD cord-010092-uftc8inx 8126 30 ml ml NN cord-010092-uftc8inx 8126 31 inoculation inoculation NN cord-010092-uftc8inx 8126 32 into into IN cord-010092-uftc8inx 8126 33 anaerobic anaerobic JJ cord-010092-uftc8inx 8126 34 and and CC cord-010092-uftc8inx 8126 35 aerobic aerobic JJ cord-010092-uftc8inx 8126 36 bottles bottle NNS cord-010092-uftc8inx 8126 37 ( ( -LRB- cord-010092-uftc8inx 8126 38 positive positive JJ cord-010092-uftc8inx 8126 39 control control NN cord-010092-uftc8inx 8126 40 ) ) -RRB- cord-010092-uftc8inx 8126 41 . . . cord-010092-uftc8inx 8127 1 Enumeration enumeration NN cord-010092-uftc8inx 8127 2 was be VBD cord-010092-uftc8inx 8127 3 performed perform VBN cord-010092-uftc8inx 8127 4 to to TO cord-010092-uftc8inx 8127 5 confirm confirm VB cord-010092-uftc8inx 8127 6 the the DT cord-010092-uftc8inx 8127 7 bacterial bacterial JJ cord-010092-uftc8inx 8127 8 concentration concentration NN cord-010092-uftc8inx 8127 9 . . . cord-010092-uftc8inx 8128 1 Each each DT cord-010092-uftc8inx 8128 2 unit unit NN cord-010092-uftc8inx 8128 3 was be VBD cord-010092-uftc8inx 8128 4 sampled sample VBN cord-010092-uftc8inx 8128 5 using use VBG cord-010092-uftc8inx 8128 6 two two CD cord-010092-uftc8inx 8128 7 10 10 CD cord-010092-uftc8inx 8128 8 ml ml NN cord-010092-uftc8inx 8128 9 SSK SSK NNP cord-010092-uftc8inx 8128 10 , , , cord-010092-uftc8inx 8128 11 which which WDT cord-010092-uftc8inx 8128 12 were be VBD cord-010092-uftc8inx 8128 13 held hold VBN cord-010092-uftc8inx 8128 14 for for IN cord-010092-uftc8inx 8128 15 a a DT cord-010092-uftc8inx 8128 16 period period NN cord-010092-uftc8inx 8128 17 of of IN cord-010092-uftc8inx 8128 18 6 6 CD cord-010092-uftc8inx 8128 19 h h NN cord-010092-uftc8inx 8128 20 at at IN cord-010092-uftc8inx 8128 21 20 20 CD cord-010092-uftc8inx 8128 22 - - SYM cord-010092-uftc8inx 8128 23 25 25 CD cord-010092-uftc8inx 8128 24 ° ° NN cord-010092-uftc8inx 8128 25 C c NN cord-010092-uftc8inx 8128 26 . . . cord-010092-uftc8inx 8129 1 The the DT cord-010092-uftc8inx 8129 2 process process NN cord-010092-uftc8inx 8129 3 was be VBD cord-010092-uftc8inx 8129 4 repeated repeat VBN cord-010092-uftc8inx 8129 5 with with IN cord-010092-uftc8inx 8129 6 a a DT cord-010092-uftc8inx 8129 7 24-h 24-h JJ cord-010092-uftc8inx 8129 8 period period NN cord-010092-uftc8inx 8129 9 . . . cord-010092-uftc8inx 8130 1 Once once RB cord-010092-uftc8inx 8130 2 elapsed elapse VBN cord-010092-uftc8inx 8130 3 , , , cord-010092-uftc8inx 8130 4 8 8 CD cord-010092-uftc8inx 8130 5 ml ml NNS cord-010092-uftc8inx 8130 6 of of IN cord-010092-uftc8inx 8130 7 each each DT cord-010092-uftc8inx 8130 8 SSK SSK NNP cord-010092-uftc8inx 8130 9 was be VBD cord-010092-uftc8inx 8130 10 inoculated inoculate VBN cord-010092-uftc8inx 8130 11 into into IN cord-010092-uftc8inx 8130 12 an an DT cord-010092-uftc8inx 8130 13 aerobic aerobic JJ cord-010092-uftc8inx 8130 14 and and CC cord-010092-uftc8inx 8130 15 anaerobic anaerobic JJ cord-010092-uftc8inx 8130 16 BacT BacT NNP cord-010092-uftc8inx 8130 17 / / SYM cord-010092-uftc8inx 8130 18 ALERT alert NN cord-010092-uftc8inx 8130 19 bottle bottle NN cord-010092-uftc8inx 8130 20 , , , cord-010092-uftc8inx 8130 21 one one CD cord-010092-uftc8inx 8130 22 SSK ssk NN cord-010092-uftc8inx 8130 23 per per IN cord-010092-uftc8inx 8130 24 atmosphere atmosphere NN cord-010092-uftc8inx 8130 25 per per IN cord-010092-uftc8inx 8130 26 species specie NNS cord-010092-uftc8inx 8130 27 and and CC cord-010092-uftc8inx 8130 28 the the DT cord-010092-uftc8inx 8130 29 remaining remain VBG cord-010092-uftc8inx 8130 30 sample sample NN cord-010092-uftc8inx 8130 31 was be VBD cord-010092-uftc8inx 8130 32 enumerated enumerate VBN cord-010092-uftc8inx 8130 33 . . . cord-010092-uftc8inx 8131 1 All all DT cord-010092-uftc8inx 8131 2 bottles bottle NNS cord-010092-uftc8inx 8131 3 were be VBD cord-010092-uftc8inx 8131 4 incubated incubate VBN cord-010092-uftc8inx 8131 5 on on IN cord-010092-uftc8inx 8131 6 the the DT cord-010092-uftc8inx 8131 7 BacT/ BacT/ NNP cord-010092-uftc8inx 8131 8 ALERT ALERT NNP cord-010092-uftc8inx 8131 9 system system NN cord-010092-uftc8inx 8131 10 for for IN cord-010092-uftc8inx 8131 11 a a DT cord-010092-uftc8inx 8131 12 maximum maximum NN cord-010092-uftc8inx 8131 13 of of IN cord-010092-uftc8inx 8131 14 7 7 CD cord-010092-uftc8inx 8131 15 days day NNS cord-010092-uftc8inx 8131 16 ( ( -LRB- cord-010092-uftc8inx 8131 17 36AE0.5 36AE0.5 NNP cord-010092-uftc8inx 8131 18 ° ° NNP cord-010092-uftc8inx 8131 19 C C NNP cord-010092-uftc8inx 8131 20 ) ) -RRB- cord-010092-uftc8inx 8131 21 and and CC cord-010092-uftc8inx 8131 22 subcultured subculture VBD cord-010092-uftc8inx 8131 23 if if IN cord-010092-uftc8inx 8131 24 positive positive JJ cord-010092-uftc8inx 8131 25 . . . cord-010092-uftc8inx 8132 1 Results result NNS cord-010092-uftc8inx 8132 2 : : : cord-010092-uftc8inx 8133 1 Positive positive JJ cord-010092-uftc8inx 8133 2 controls control NNS cord-010092-uftc8inx 8133 3 had have VBD cord-010092-uftc8inx 8133 4 detectable detectable JJ cord-010092-uftc8inx 8133 5 growth growth NN cord-010092-uftc8inx 8133 6 by by IN cord-010092-uftc8inx 8133 7 BacT BacT NNP cord-010092-uftc8inx 8133 8 / / SYM cord-010092-uftc8inx 8133 9 ALERT ALERT NNP cord-010092-uftc8inx 8133 10 , , , cord-010092-uftc8inx 8133 11 excluding exclude VBG cord-010092-uftc8inx 8133 12 aerobic aerobic JJ cord-010092-uftc8inx 8133 13 bottles bottle NNS cord-010092-uftc8inx 8133 14 with with IN cord-010092-uftc8inx 8133 15 C. C. NNP cord-010092-uftc8inx 8133 16 perfringens perfringen NNS cord-010092-uftc8inx 8133 17 . . . cord-010092-uftc8inx 8134 1 This this DT cord-010092-uftc8inx 8134 2 was be VBD cord-010092-uftc8inx 8134 3 expected expect VBN cord-010092-uftc8inx 8134 4 as as IN cord-010092-uftc8inx 8134 5 it -PRON- PRP cord-010092-uftc8inx 8134 6 is be VBZ cord-010092-uftc8inx 8134 7 an an DT cord-010092-uftc8inx 8134 8 anaerobic anaerobic JJ cord-010092-uftc8inx 8134 9 organism organism NN cord-010092-uftc8inx 8134 10 . . . cord-010092-uftc8inx 8135 1 After after IN cord-010092-uftc8inx 8135 2 the the DT cord-010092-uftc8inx 8135 3 storage storage NN cord-010092-uftc8inx 8135 4 periods period NNS cord-010092-uftc8inx 8135 5 , , , cord-010092-uftc8inx 8135 6 all all DT cord-010092-uftc8inx 8135 7 bottles bottle NNS cord-010092-uftc8inx 8135 8 had have VBD cord-010092-uftc8inx 8135 9 detectable detectable JJ cord-010092-uftc8inx 8135 10 growth growth NN cord-010092-uftc8inx 8135 11 by by IN cord-010092-uftc8inx 8135 12 BacT BacT NNP cord-010092-uftc8inx 8135 13 / / SYM cord-010092-uftc8inx 8135 14 ALERT ALERT NNP cord-010092-uftc8inx 8135 15 . . . cord-010092-uftc8inx 8136 1 S. S. NNP cord-010092-uftc8inx 8136 2 aureus aureu NNS cord-010092-uftc8inx 8136 3 showed show VBD cord-010092-uftc8inx 8136 4 an an DT cord-010092-uftc8inx 8136 5 increase increase NN cord-010092-uftc8inx 8136 6 of of IN cord-010092-uftc8inx 8136 7 0.6-Log10 0.6-log10 CD cord-010092-uftc8inx 8136 8 after after IN cord-010092-uftc8inx 8136 9 6 6 CD cord-010092-uftc8inx 8136 10 h h NN cord-010092-uftc8inx 8136 11 ( ( -LRB- cord-010092-uftc8inx 8136 12 2.0 2.0 CD cord-010092-uftc8inx 8136 13 9 9 CD cord-010092-uftc8inx 8136 14 102 102 CD cord-010092-uftc8inx 8136 15 to to TO cord-010092-uftc8inx 8136 16 8.9 8.9 CD cord-010092-uftc8inx 8136 17 9 9 CD cord-010092-uftc8inx 8136 18 102 102 CD cord-010092-uftc8inx 8136 19 CFU CFU NNP cord-010092-uftc8inx 8136 20 / / SYM cord-010092-uftc8inx 8136 21 ml ml NN cord-010092-uftc8inx 8136 22 ) ) -RRB- cord-010092-uftc8inx 8136 23 and and CC cord-010092-uftc8inx 8136 24 2.0-Log10 2.0-log10 CD cord-010092-uftc8inx 8136 25 after after IN cord-010092-uftc8inx 8136 26 24 24 CD cord-010092-uftc8inx 8136 27 h h NN cord-010092-uftc8inx 8136 28 ( ( -LRB- cord-010092-uftc8inx 8136 29 3.1 3.1 CD cord-010092-uftc8inx 8136 30 9 9 CD cord-010092-uftc8inx 8136 31 101 101 CD cord-010092-uftc8inx 8136 32 CFU CFU NNP cord-010092-uftc8inx 8136 33 / / SYM cord-010092-uftc8inx 8136 34 ml ml NN cord-010092-uftc8inx 8137 1 to to IN cord-010092-uftc8inx 8137 2 3.4 3.4 CD cord-010092-uftc8inx 8137 3 9 9 CD cord-010092-uftc8inx 8137 4 103 103 CD cord-010092-uftc8inx 8137 5 CFU CFU NNP cord-010092-uftc8inx 8137 6 / / SYM cord-010092-uftc8inx 8137 7 ml ml NN cord-010092-uftc8inx 8137 8 ) ) -RRB- cord-010092-uftc8inx 8137 9 . . . cord-010092-uftc8inx 8138 1 S. S. NNP cord-010092-uftc8inx 8138 2 agalactiae agalactiae NNP cord-010092-uftc8inx 8138 3 increased increase VBN cord-010092-uftc8inx 8138 4 by by IN cord-010092-uftc8inx 8138 5 0.7-Log10 0.7-log10 CD cord-010092-uftc8inx 8138 6 after after IN cord-010092-uftc8inx 8138 7 6 6 CD cord-010092-uftc8inx 8138 8 h h NN cord-010092-uftc8inx 8138 9 ( ( -LRB- cord-010092-uftc8inx 8138 10 2.1 2.1 CD cord-010092-uftc8inx 8138 11 9 9 CD cord-010092-uftc8inx 8138 12 102 102 CD cord-010092-uftc8inx 8138 13 CFU CFU NNP cord-010092-uftc8inx 8138 14 / / SYM cord-010092-uftc8inx 8138 15 ml ml NNS cord-010092-uftc8inx 8138 16 to to IN cord-010092-uftc8inx 8138 17 1.1 1.1 CD cord-010092-uftc8inx 8138 18 9 9 CD cord-010092-uftc8inx 8138 19 103 103 CD cord-010092-uftc8inx 8138 20 CFU CFU NNP cord-010092-uftc8inx 8138 21 / / SYM cord-010092-uftc8inx 8138 22 ml ml NN cord-010092-uftc8inx 8138 23 ) ) -RRB- cord-010092-uftc8inx 8139 1 and and CC cord-010092-uftc8inx 8139 2 0.09-Log10 0.09-log10 CD cord-010092-uftc8inx 8139 3 after after IN cord-010092-uftc8inx 8139 4 24 24 CD cord-010092-uftc8inx 8139 5 h h NN cord-010092-uftc8inx 8139 6 ( ( -LRB- cord-010092-uftc8inx 8139 7 1.0 1.0 CD cord-010092-uftc8inx 8139 8 9 9 CD cord-010092-uftc8inx 8139 9 102 102 CD cord-010092-uftc8inx 8139 10 CFU CFU NNP cord-010092-uftc8inx 8139 11 / / SYM cord-010092-uftc8inx 8139 12 ml ml NNS cord-010092-uftc8inx 8139 13 to to IN cord-010092-uftc8inx 8139 14 1.2 1.2 CD cord-010092-uftc8inx 8139 15 9 9 CD cord-010092-uftc8inx 8139 16 102 102 CD cord-010092-uftc8inx 8139 17 CFU CFU NNP cord-010092-uftc8inx 8139 18 / / SYM cord-010092-uftc8inx 8139 19 ml ml NN cord-010092-uftc8inx 8139 20 ) ) -RRB- cord-010092-uftc8inx 8139 21 . . . cord-010092-uftc8inx 8140 1 C C NNP cord-010092-uftc8inx 8140 2 perfringens perfringens NN cord-010092-uftc8inx 8140 3 increased increase VBN cord-010092-uftc8inx 8140 4 by by IN cord-010092-uftc8inx 8140 5 0.6-Log10 0.6-log10 CD cord-010092-uftc8inx 8140 6 after after IN cord-010092-uftc8inx 8140 7 6 6 CD cord-010092-uftc8inx 8140 8 h h NN cord-010092-uftc8inx 8140 9 ( ( -LRB- cord-010092-uftc8inx 8140 10 1.3 1.3 CD cord-010092-uftc8inx 8140 11 9 9 CD cord-010092-uftc8inx 8140 12 102 102 CD cord-010092-uftc8inx 8140 13 CFU CFU NNP cord-010092-uftc8inx 8140 14 / / SYM cord-010092-uftc8inx 8140 15 ml ml NNS cord-010092-uftc8inx 8140 16 to to IN cord-010092-uftc8inx 8140 17 5.0 5.0 CD cord-010092-uftc8inx 8140 18 9 9 CD cord-010092-uftc8inx 8140 19 102 102 CD cord-010092-uftc8inx 8140 20 CFU CFU NNP cord-010092-uftc8inx 8140 21 / / SYM cord-010092-uftc8inx 8140 22 ml ml NN cord-010092-uftc8inx 8140 23 ) ) -RRB- cord-010092-uftc8inx 8140 24 and and CC cord-010092-uftc8inx 8140 25 2.7-Log10 2.7-log10 CD cord-010092-uftc8inx 8140 26 after after IN cord-010092-uftc8inx 8140 27 24 24 CD cord-010092-uftc8inx 8140 28 h h NN cord-010092-uftc8inx 8140 29 ( ( -LRB- cord-010092-uftc8inx 8140 30 4.0 4.0 CD cord-010092-uftc8inx 8140 31 9 9 CD cord-010092-uftc8inx 8140 32 100 100 CD cord-010092-uftc8inx 8140 33 CFU CFU NNP cord-010092-uftc8inx 8140 34 / / SYM cord-010092-uftc8inx 8140 35 ml ml NN cord-010092-uftc8inx 8140 36 and and CC cord-010092-uftc8inx 8140 37 2.2 2.2 CD cord-010092-uftc8inx 8140 38 9 9 CD cord-010092-uftc8inx 8140 39 103 103 CD cord-010092-uftc8inx 8140 40 CFU CFU NNP cord-010092-uftc8inx 8140 41 / / SYM cord-010092-uftc8inx 8140 42 ml ml NN cord-010092-uftc8inx 8140 43 ) ) -RRB- cord-010092-uftc8inx 8140 44 . . . cord-010092-uftc8inx 8141 1 For for IN cord-010092-uftc8inx 8141 2 E. E. NNP cord-010092-uftc8inx 8141 3 coli coli NNS cord-010092-uftc8inx 8141 4 , , , cord-010092-uftc8inx 8141 5 the the DT cord-010092-uftc8inx 8141 6 concentration concentration NN cord-010092-uftc8inx 8141 7 after after IN cord-010092-uftc8inx 8141 8 6 6 CD cord-010092-uftc8inx 8141 9 h h NN cord-010092-uftc8inx 8141 10 was be VBD cord-010092-uftc8inx 8141 11 reduced reduce VBN cord-010092-uftc8inx 8141 12 by by IN cord-010092-uftc8inx 8141 13 0.28-Log10 0.28-log10 CD cord-010092-uftc8inx 8141 14 ( ( -LRB- cord-010092-uftc8inx 8141 15 2.8 2.8 CD cord-010092-uftc8inx 8141 16 9 9 CD cord-010092-uftc8inx 8141 17 103 103 CD cord-010092-uftc8inx 8141 18 CFU CFU NNP cord-010092-uftc8inx 8141 19 / / SYM cord-010092-uftc8inx 8141 20 ml ml NN cord-010092-uftc8inx 8141 21 and and CC cord-010092-uftc8inx 8141 22 1.5 1.5 CD cord-010092-uftc8inx 8141 23 9 9 CD cord-010092-uftc8inx 8141 24 103 103 CD cord-010092-uftc8inx 8141 25 CFU CFU NNP cord-010092-uftc8inx 8141 26 / / SYM cord-010092-uftc8inx 8141 27 ml ml NN cord-010092-uftc8inx 8141 28 ) ) -RRB- cord-010092-uftc8inx 8141 29 , , , cord-010092-uftc8inx 8141 30 however however RB cord-010092-uftc8inx 8141 31 this this DT cord-010092-uftc8inx 8141 32 was be VBD cord-010092-uftc8inx 8141 33 possibly possibly RB cord-010092-uftc8inx 8141 34 a a DT cord-010092-uftc8inx 8141 35 result result NN cord-010092-uftc8inx 8141 36 of of IN cord-010092-uftc8inx 8141 37 inherent inherent JJ cord-010092-uftc8inx 8141 38 counting counting NN cord-010092-uftc8inx 8141 39 errors error NNS cord-010092-uftc8inx 8141 40 . . . cord-010092-uftc8inx 8142 1 At at IN cord-010092-uftc8inx 8142 2 24 24 CD cord-010092-uftc8inx 8142 3 h h NN cord-010092-uftc8inx 8142 4 , , , cord-010092-uftc8inx 8142 5 an an DT cord-010092-uftc8inx 8142 6 increase increase NN cord-010092-uftc8inx 8142 7 in in IN cord-010092-uftc8inx 8142 8 growth growth NN cord-010092-uftc8inx 8142 9 by by IN cord-010092-uftc8inx 8142 10 2.7-Log10 2.7-log10 CD cord-010092-uftc8inx 8142 11 ( ( -LRB- cord-010092-uftc8inx 8142 12 1.5 1.5 CD cord-010092-uftc8inx 8142 13 9 9 CD cord-010092-uftc8inx 8142 14 102 102 CD cord-010092-uftc8inx 8142 15 to to IN cord-010092-uftc8inx 8142 16 7.9 7.9 CD cord-010092-uftc8inx 8142 17 9 9 CD cord-010092-uftc8inx 8142 18 104 104 CD cord-010092-uftc8inx 8142 19 CFU CFU NNP cord-010092-uftc8inx 8142 20 / / SYM cord-010092-uftc8inx 8142 21 ml ml NN cord-010092-uftc8inx 8142 22 ) ) -RRB- cord-010092-uftc8inx 8142 23 was be VBD cord-010092-uftc8inx 8142 24 obtained obtain VBN cord-010092-uftc8inx 8142 25 . . . cord-010092-uftc8inx 8143 1 Summary Summary NNP cord-010092-uftc8inx 8143 2 / / SYM cord-010092-uftc8inx 8143 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 8143 4 : : : cord-010092-uftc8inx 8144 1 Storage storage NN cord-010092-uftc8inx 8144 2 of of IN cord-010092-uftc8inx 8144 3 PC pc NN cord-010092-uftc8inx 8144 4 samples sample NNS cord-010092-uftc8inx 8144 5 in in IN cord-010092-uftc8inx 8144 6 SSK SSK NNP cord-010092-uftc8inx 8144 7 devices device NNS cord-010092-uftc8inx 8144 8 for for IN cord-010092-uftc8inx 8144 9 up up IN cord-010092-uftc8inx 8144 10 to to TO cord-010092-uftc8inx 8144 11 24 24 CD cord-010092-uftc8inx 8144 12 h h NN cord-010092-uftc8inx 8144 13 does do VBZ cord-010092-uftc8inx 8144 14 not not RB cord-010092-uftc8inx 8144 15 have have VB cord-010092-uftc8inx 8144 16 a a DT cord-010092-uftc8inx 8144 17 negative negative JJ cord-010092-uftc8inx 8144 18 effect effect NN cord-010092-uftc8inx 8144 19 on on IN cord-010092-uftc8inx 8144 20 bacterial bacterial JJ cord-010092-uftc8inx 8144 21 viability viability NN cord-010092-uftc8inx 8144 22 and and CC cord-010092-uftc8inx 8144 23 detection detection NN cord-010092-uftc8inx 8144 24 using use VBG cord-010092-uftc8inx 8144 25 the the DT cord-010092-uftc8inx 8144 26 BacT BacT NNP cord-010092-uftc8inx 8144 27 / / SYM cord-010092-uftc8inx 8144 28 ALERT ALERT NNP cord-010092-uftc8inx 8144 29 3D 3d JJ cord-010092-uftc8inx 8144 30 system system NN cord-010092-uftc8inx 8144 31 . . . cord-010092-uftc8inx 8145 1 Background background NN cord-010092-uftc8inx 8145 2 : : : cord-010092-uftc8inx 8146 1 The the DT cord-010092-uftc8inx 8146 2 INTERCEPT INTERCEPT NNP cord-010092-uftc8inx 8146 3 TM TM NNP cord-010092-uftc8inx 8146 4 Blood Blood NNP cord-010092-uftc8inx 8146 5 System System NNP cord-010092-uftc8inx 8146 6 for for IN cord-010092-uftc8inx 8146 7 Platelets platelet NNS cord-010092-uftc8inx 8146 8 efficiently efficiently RB cord-010092-uftc8inx 8146 9 inactivates inactivate VBZ cord-010092-uftc8inx 8146 10 pathogens pathogen NNS cord-010092-uftc8inx 8146 11 and and CC cord-010092-uftc8inx 8146 12 leukocytes leukocyte NNS cord-010092-uftc8inx 8146 13 in in IN cord-010092-uftc8inx 8146 14 platelet platelet NN cord-010092-uftc8inx 8146 15 concentrates concentrate NNS cord-010092-uftc8inx 8146 16 ( ( -LRB- cord-010092-uftc8inx 8146 17 PC pc NN cord-010092-uftc8inx 8146 18 ) ) -RRB- cord-010092-uftc8inx 8146 19 . . . cord-010092-uftc8inx 8147 1 The the DT cord-010092-uftc8inx 8147 2 system system NN cord-010092-uftc8inx 8147 3 utilizes utilize VBZ cord-010092-uftc8inx 8147 4 amotosalen amotosalen VBN cord-010092-uftc8inx 8147 5 and and CC cord-010092-uftc8inx 8147 6 UVA UVA NNP cord-010092-uftc8inx 8147 7 light light NN cord-010092-uftc8inx 8147 8 and and CC cord-010092-uftc8inx 8147 9 is be VBZ cord-010092-uftc8inx 8147 10 available available JJ cord-010092-uftc8inx 8147 11 for for IN cord-010092-uftc8inx 8147 12 the the DT cord-010092-uftc8inx 8147 13 treatment treatment NN cord-010092-uftc8inx 8147 14 of of IN cord-010092-uftc8inx 8147 15 apheresis apheresis NN cord-010092-uftc8inx 8147 16 and and CC cord-010092-uftc8inx 8147 17 whole whole JJ cord-010092-uftc8inx 8147 18 blood blood NN cord-010092-uftc8inx 8147 19 ( ( -LRB- cord-010092-uftc8inx 8147 20 WB WB NNP cord-010092-uftc8inx 8147 21 ) ) -RRB- cord-010092-uftc8inx 8147 22 derived derive VBN cord-010092-uftc8inx 8147 23 platelets platelet NNS cord-010092-uftc8inx 8147 24 ( ( -LRB- cord-010092-uftc8inx 8147 25 mostly mostly RB cord-010092-uftc8inx 8147 26 buffy buffy NNP cord-010092-uftc8inx 8147 27 coat coat NN cord-010092-uftc8inx 8147 28 pools pool NNS cord-010092-uftc8inx 8147 29 ) ) -RRB- cord-010092-uftc8inx 8147 30 in in IN cord-010092-uftc8inx 8147 31 Europe Europe NNP cord-010092-uftc8inx 8147 32 in in IN cord-010092-uftc8inx 8147 33 plasma plasma NN cord-010092-uftc8inx 8147 34 or or CC cord-010092-uftc8inx 8147 35 platelet platelet NN cord-010092-uftc8inx 8147 36 additive additive NN cord-010092-uftc8inx 8147 37 solution solution NN cord-010092-uftc8inx 8147 38 ( ( -LRB- cord-010092-uftc8inx 8147 39 PAS pas NN cord-010092-uftc8inx 8147 40 ) ) -RRB- cord-010092-uftc8inx 8147 41 , , , cord-010092-uftc8inx 8147 42 and and CC cord-010092-uftc8inx 8147 43 the the DT cord-010092-uftc8inx 8147 44 treatment treatment NN cord-010092-uftc8inx 8147 45 of of IN cord-010092-uftc8inx 8147 46 apheresis apheresis NN cord-010092-uftc8inx 8147 47 platelets platelet NNS cord-010092-uftc8inx 8147 48 in in IN cord-010092-uftc8inx 8147 49 the the DT cord-010092-uftc8inx 8147 50 US US NNP cord-010092-uftc8inx 8147 51 ( ( -LRB- cord-010092-uftc8inx 8147 52 TRIMA TRIMA NNP cord-010092-uftc8inx 8147 53 TM TM NNP cord-010092-uftc8inx 8147 54 in in IN cord-010092-uftc8inx 8147 55 100 100 CD cord-010092-uftc8inx 8147 56 % % NN cord-010092-uftc8inx 8147 57 plasma plasma NN cord-010092-uftc8inx 8147 58 or or CC cord-010092-uftc8inx 8147 59 AMICUS AMICUS NNP cord-010092-uftc8inx 8147 60 TM TM NNP cord-010092-uftc8inx 8147 61 for for IN cord-010092-uftc8inx 8147 62 65 65 CD cord-010092-uftc8inx 8147 63 % % NN cord-010092-uftc8inx 8147 64 InterSol InterSol NNS cord-010092-uftc8inx 8147 65 PAS/35 PAS/35 JJR cord-010092-uftc8inx 8147 66 % % NN cord-010092-uftc8inx 8147 67 plasma plasma NN cord-010092-uftc8inx 8147 68 ) ) -RRB- cord-010092-uftc8inx 8147 69 . . . cord-010092-uftc8inx 8148 1 Acinetobacter Acinetobacter NNP cord-010092-uftc8inx 8148 2 baumanii baumanii NNP cord-010092-uftc8inx 8148 3 and and CC cord-010092-uftc8inx 8148 4 Staphylococcus Staphylococcus NNP cord-010092-uftc8inx 8148 5 saprophyticus saprophyticus NN cord-010092-uftc8inx 8148 6 strains strain NNS cord-010092-uftc8inx 8148 7 were be VBD cord-010092-uftc8inx 8148 8 isolated isolate VBN cord-010092-uftc8inx 8148 9 from from IN cord-010092-uftc8inx 8148 10 a a DT cord-010092-uftc8inx 8148 11 saline saline NN cord-010092-uftc8inx 8148 12 flush flush NN cord-010092-uftc8inx 8148 13 taken take VBN cord-010092-uftc8inx 8148 14 7 7 CD cord-010092-uftc8inx 8148 15 h h NN cord-010092-uftc8inx 8148 16 after after IN cord-010092-uftc8inx 8148 17 successful successful JJ cord-010092-uftc8inx 8148 18 and and CC cord-010092-uftc8inx 8148 19 complete complete JJ cord-010092-uftc8inx 8148 20 transfusion transfusion NN cord-010092-uftc8inx 8148 21 of of IN cord-010092-uftc8inx 8148 22 an an DT cord-010092-uftc8inx 8148 23 apheresis apheresis NN cord-010092-uftc8inx 8148 24 INTERCEPT intercept NN cord-010092-uftc8inx 8148 25 - - HYPH cord-010092-uftc8inx 8148 26 treated treat VBN cord-010092-uftc8inx 8148 27 PC pc NN cord-010092-uftc8inx 8148 28 in in IN cord-010092-uftc8inx 8148 29 65 65 CD cord-010092-uftc8inx 8148 30 % % NN cord-010092-uftc8inx 8148 31 PAS/35 pas/35 NN cord-010092-uftc8inx 8148 32 % % NN cord-010092-uftc8inx 8148 33 plasma plasma NN cord-010092-uftc8inx 8148 34 , , , cord-010092-uftc8inx 8148 35 from from IN cord-010092-uftc8inx 8148 36 a a DT cord-010092-uftc8inx 8148 37 patient patient NN cord-010092-uftc8inx 8148 38 with with IN cord-010092-uftc8inx 8148 39 a a DT cord-010092-uftc8inx 8148 40 suspected suspect VBN cord-010092-uftc8inx 8148 41 septic septic JJ cord-010092-uftc8inx 8148 42 reaction reaction NN cord-010092-uftc8inx 8148 43 that that WDT cord-010092-uftc8inx 8148 44 occurred occur VBD cord-010092-uftc8inx 8148 45 2 2 CD cord-010092-uftc8inx 8148 46 h h NN cord-010092-uftc8inx 8148 47 post post NN cord-010092-uftc8inx 8148 48 transfusion transfusion NN cord-010092-uftc8inx 8148 49 . . . cord-010092-uftc8inx 8149 1 Bacterial bacterial JJ cord-010092-uftc8inx 8149 2 isolates isolate NNS cord-010092-uftc8inx 8149 3 , , , cord-010092-uftc8inx 8149 4 and and CC cord-010092-uftc8inx 8149 5 a a DT cord-010092-uftc8inx 8149 6 sample sample NN cord-010092-uftc8inx 8149 7 of of IN cord-010092-uftc8inx 8149 8 a a DT cord-010092-uftc8inx 8149 9 Gram Gram NNP cord-010092-uftc8inx 8149 10 stain stain NN cord-010092-uftc8inx 8149 11 - - HYPH cord-010092-uftc8inx 8149 12 negative negative JJ cord-010092-uftc8inx 8149 13 and and CC cord-010092-uftc8inx 8149 14 culture culture NN cord-010092-uftc8inx 8149 15 - - HYPH cord-010092-uftc8inx 8149 16 negative negative JJ cord-010092-uftc8inx 8149 17 sister sister NN cord-010092-uftc8inx 8149 18 split split NN cord-010092-uftc8inx 8149 19 PC PC NNP cord-010092-uftc8inx 8149 20 were be VBD cord-010092-uftc8inx 8149 21 submitted submit VBN cord-010092-uftc8inx 8149 22 for for IN cord-010092-uftc8inx 8149 23 evaluation evaluation NN cord-010092-uftc8inx 8149 24 . . . cord-010092-uftc8inx 8150 1 We -PRON- PRP cord-010092-uftc8inx 8150 2 report report VBP cord-010092-uftc8inx 8150 3 here here RB cord-010092-uftc8inx 8150 4 the the DT cord-010092-uftc8inx 8150 5 in in FW cord-010092-uftc8inx 8150 6 vitro vitro FW cord-010092-uftc8inx 8150 7 inactivation inactivation NN cord-010092-uftc8inx 8150 8 of of IN cord-010092-uftc8inx 8150 9 the the DT cord-010092-uftc8inx 8150 10 fast fast JJ cord-010092-uftc8inx 8150 11 growing growing NN cord-010092-uftc8inx 8150 12 , , , cord-010092-uftc8inx 8150 13 gram gram NN cord-010092-uftc8inx 8150 14 negative negative JJ cord-010092-uftc8inx 8150 15 bacterium bacterium NN cord-010092-uftc8inx 8150 16 A. a. NN cord-010092-uftc8inx 8150 17 baumanii baumanii NN cord-010092-uftc8inx 8150 18 and and CC cord-010092-uftc8inx 8150 19 slower slow RBR cord-010092-uftc8inx 8150 20 growing grow VBG cord-010092-uftc8inx 8150 21 Gram Gram NNP cord-010092-uftc8inx 8150 22 positive positive JJ cord-010092-uftc8inx 8150 23 S. S. NNP cord-010092-uftc8inx 8150 24 saprophyticus saprophyticus NN cord-010092-uftc8inx 8150 25 . . . cord-010092-uftc8inx 8151 1 The the DT cord-010092-uftc8inx 8151 2 sister sister NN cord-010092-uftc8inx 8151 3 unit unit NN cord-010092-uftc8inx 8151 4 was be VBD cord-010092-uftc8inx 8151 5 assessed assess VBN cord-010092-uftc8inx 8151 6 for for IN cord-010092-uftc8inx 8151 7 amotosalen amotosalen NNP cord-010092-uftc8inx 8151 8 break break NN cord-010092-uftc8inx 8151 9 down down RP cord-010092-uftc8inx 8151 10 products product NNS cord-010092-uftc8inx 8151 11 as as IN cord-010092-uftc8inx 8151 12 an an DT cord-010092-uftc8inx 8151 13 indication indication NN cord-010092-uftc8inx 8151 14 of of IN cord-010092-uftc8inx 8151 15 successful successful JJ cord-010092-uftc8inx 8151 16 INTER INTER NNP cord-010092-uftc8inx 8151 17 - - HYPH cord-010092-uftc8inx 8151 18 CEPT CEPT NNP cord-010092-uftc8inx 8151 19 treatment treatment NN cord-010092-uftc8inx 8151 20 . . . cord-010092-uftc8inx 8152 1 Aims aim VBZ cord-010092-uftc8inx 8152 2 : : : cord-010092-uftc8inx 8153 1 The the DT cord-010092-uftc8inx 8153 2 objective objective NN cord-010092-uftc8inx 8153 3 of of IN cord-010092-uftc8inx 8153 4 the the DT cord-010092-uftc8inx 8153 5 study study NN cord-010092-uftc8inx 8153 6 was be VBD cord-010092-uftc8inx 8153 7 to to TO cord-010092-uftc8inx 8153 8 evaluate evaluate VB cord-010092-uftc8inx 8153 9 bacterial bacterial JJ cord-010092-uftc8inx 8153 10 inactivation inactivation NN cord-010092-uftc8inx 8153 11 of of IN cord-010092-uftc8inx 8153 12 A. a. NN cord-010092-uftc8inx 8153 13 baumanii baumanii NNP cord-010092-uftc8inx 8153 14 and and CC cord-010092-uftc8inx 8153 15 S. S. NNP cord-010092-uftc8inx 8153 16 saprophyticus saprophyticus NN cord-010092-uftc8inx 8153 17 in in IN cord-010092-uftc8inx 8153 18 apheresis apheresis NN cord-010092-uftc8inx 8153 19 platelets platelet NNS cord-010092-uftc8inx 8153 20 , , , cord-010092-uftc8inx 8153 21 assessed assess VBN cord-010092-uftc8inx 8153 22 immediately immediately RB cord-010092-uftc8inx 8153 23 after after IN cord-010092-uftc8inx 8153 24 treatment treatment NN cord-010092-uftc8inx 8153 25 and and CC cord-010092-uftc8inx 8153 26 with with IN cord-010092-uftc8inx 8153 27 re re NN cord-010092-uftc8inx 8153 28 - - NN cord-010092-uftc8inx 8153 29 culture culture NN cord-010092-uftc8inx 8153 30 at at IN cord-010092-uftc8inx 8153 31 the the DT cord-010092-uftc8inx 8153 32 end end NN cord-010092-uftc8inx 8153 33 of of IN cord-010092-uftc8inx 8153 34 a a DT cord-010092-uftc8inx 8153 35 7 7 CD cord-010092-uftc8inx 8153 36 day day NN cord-010092-uftc8inx 8153 37 shelf shelf NN cord-010092-uftc8inx 8153 38 - - HYPH cord-010092-uftc8inx 8153 39 life life NN cord-010092-uftc8inx 8153 40 . . . cord-010092-uftc8inx 8154 1 Methods method NNS cord-010092-uftc8inx 8154 2 : : : cord-010092-uftc8inx 8155 1 A a DT cord-010092-uftc8inx 8155 2 double double JJ cord-010092-uftc8inx 8155 3 apheresis apheresis NN cord-010092-uftc8inx 8155 4 PC pc NN cord-010092-uftc8inx 8155 5 collected collect VBN cord-010092-uftc8inx 8155 6 in in IN cord-010092-uftc8inx 8155 7 65 65 CD cord-010092-uftc8inx 8155 8 % % NN cord-010092-uftc8inx 8155 9 PAS/35 pas/35 NN cord-010092-uftc8inx 8155 10 % % NN cord-010092-uftc8inx 8155 11 plasma plasma NN cord-010092-uftc8inx 8155 12 was be VBD cord-010092-uftc8inx 8155 13 split split VBN cord-010092-uftc8inx 8155 14 into into IN cord-010092-uftc8inx 8155 15 three three CD cord-010092-uftc8inx 8155 16 equal equal JJ cord-010092-uftc8inx 8155 17 components component NNS cord-010092-uftc8inx 8155 18 , , , cord-010092-uftc8inx 8155 19 yielding yield VBG cord-010092-uftc8inx 8155 20 approximately approximately RB cord-010092-uftc8inx 8155 21 250 250 CD cord-010092-uftc8inx 8155 22 mL mL NNS cord-010092-uftc8inx 8155 23 of of IN cord-010092-uftc8inx 8155 24 platelets platelet NNS cord-010092-uftc8inx 8155 25 / / SYM cord-010092-uftc8inx 8155 26 PC pc NN cord-010092-uftc8inx 8155 27 . . . cord-010092-uftc8inx 8156 1 A. A. NNP cord-010092-uftc8inx 8156 2 baumanii baumanii NNP cord-010092-uftc8inx 8156 3 and and CC cord-010092-uftc8inx 8156 4 S. S. NNP cord-010092-uftc8inx 8156 5 saprophyticus saprophyticus NN cord-010092-uftc8inx 8156 6 were be VBD cord-010092-uftc8inx 8156 7 grown grow VBN cord-010092-uftc8inx 8156 8 in in IN cord-010092-uftc8inx 8156 9 LB LB NNP cord-010092-uftc8inx 8156 10 broth broth NN cord-010092-uftc8inx 8156 11 and and CC cord-010092-uftc8inx 8156 12 each each DT cord-010092-uftc8inx 8156 13 PC pc NN cord-010092-uftc8inx 8156 14 unit unit NN cord-010092-uftc8inx 8156 15 was be VBD cord-010092-uftc8inx 8156 16 inoculated inoculate VBN cord-010092-uftc8inx 8156 17 with with IN cord-010092-uftc8inx 8156 18 either either DT cord-010092-uftc8inx 8156 19 bacterial bacterial JJ cord-010092-uftc8inx 8156 20 strain strain NN cord-010092-uftc8inx 8156 21 or or CC cord-010092-uftc8inx 8156 22 the the DT cord-010092-uftc8inx 8156 23 combination combination NN cord-010092-uftc8inx 8156 24 of of IN cord-010092-uftc8inx 8156 25 both both DT cord-010092-uftc8inx 8156 26 strains strain NNS cord-010092-uftc8inx 8156 27 , , , cord-010092-uftc8inx 8156 28 each each DT cord-010092-uftc8inx 8156 29 at~6 at~6 CD cord-010092-uftc8inx 8156 30 log log NN cord-010092-uftc8inx 8156 31 colony colony NN cord-010092-uftc8inx 8156 32 forming form VBG cord-010092-uftc8inx 8156 33 units unit NNS cord-010092-uftc8inx 8156 34 / / SYM cord-010092-uftc8inx 8156 35 mL mL NNP cord-010092-uftc8inx 8156 36 ( ( -LRB- cord-010092-uftc8inx 8156 37 cfu cfu NNP cord-010092-uftc8inx 8156 38 / / SYM cord-010092-uftc8inx 8156 39 mL mL NNP cord-010092-uftc8inx 8156 40 ) ) -RRB- cord-010092-uftc8inx 8156 41 . . . cord-010092-uftc8inx 8157 1 After after IN cord-010092-uftc8inx 8157 2 inoculation inoculation NN cord-010092-uftc8inx 8157 3 , , , cord-010092-uftc8inx 8157 4 the the DT cord-010092-uftc8inx 8157 5 contaminated contaminate VBN cord-010092-uftc8inx 8157 6 units unit NNS cord-010092-uftc8inx 8157 7 were be VBD cord-010092-uftc8inx 8157 8 treated treat VBN cord-010092-uftc8inx 8157 9 in in IN cord-010092-uftc8inx 8157 10 small small JJ cord-010092-uftc8inx 8157 11 volume volume NN cord-010092-uftc8inx 8157 12 ( ( -LRB- cord-010092-uftc8inx 8157 13 SV sv NN cord-010092-uftc8inx 8157 14 ) ) -RRB- cord-010092-uftc8inx 8158 1 INTERCEPT INTERCEPT NNP cord-010092-uftc8inx 8158 2 kits kit NNS cord-010092-uftc8inx 8158 3 . . . cord-010092-uftc8inx 8159 1 Samples sample NNS cord-010092-uftc8inx 8159 2 were be VBD cord-010092-uftc8inx 8159 3 taken take VBN cord-010092-uftc8inx 8159 4 : : : cord-010092-uftc8inx 8159 5 pre pre JJ cord-010092-uftc8inx 8159 6 and and CC cord-010092-uftc8inx 8159 7 post post JJ cord-010092-uftc8inx 8159 8 - - JJ cord-010092-uftc8inx 8159 9 inactivation inactivation JJ cord-010092-uftc8inx 8159 10 treatment treatment NN cord-010092-uftc8inx 8159 11 , , , cord-010092-uftc8inx 8159 12 and and CC cord-010092-uftc8inx 8159 13 at at IN cord-010092-uftc8inx 8159 14 3 3 CD cord-010092-uftc8inx 8159 15 , , , cord-010092-uftc8inx 8159 16 5 5 CD cord-010092-uftc8inx 8159 17 and and CC cord-010092-uftc8inx 8159 18 7 7 CD cord-010092-uftc8inx 8159 19 days day NNS cord-010092-uftc8inx 8159 20 of of IN cord-010092-uftc8inx 8159 21 storage storage NN cord-010092-uftc8inx 8159 22 . . . cord-010092-uftc8inx 8160 1 The the DT cord-010092-uftc8inx 8160 2 samples sample NNS cord-010092-uftc8inx 8160 3 were be VBD cord-010092-uftc8inx 8160 4 analyzed analyze VBN cord-010092-uftc8inx 8160 5 by by IN cord-010092-uftc8inx 8160 6 plating plate VBG cord-010092-uftc8inx 8160 7 on on IN cord-010092-uftc8inx 8160 8 LB LB NNP cord-010092-uftc8inx 8160 9 plates plate NNS cord-010092-uftc8inx 8160 10 ( ( -LRB- cord-010092-uftc8inx 8160 11 100 100 CD cord-010092-uftc8inx 8160 12 lL-10 ll-10 NN cord-010092-uftc8inx 8160 13 mL ml NN cord-010092-uftc8inx 8160 14 ) ) -RRB- cord-010092-uftc8inx 8160 15 . . . cord-010092-uftc8inx 8161 1 Residual residual JJ cord-010092-uftc8inx 8161 2 amotosalen amotosalen NN cord-010092-uftc8inx 8161 3 levels level NNS cord-010092-uftc8inx 8161 4 were be VBD cord-010092-uftc8inx 8161 5 assessed assess VBN cord-010092-uftc8inx 8161 6 by by IN cord-010092-uftc8inx 8161 7 HPLC HPLC NNP cord-010092-uftc8inx 8161 8 . . . cord-010092-uftc8inx 8162 1 Results result NNS cord-010092-uftc8inx 8162 2 : : : cord-010092-uftc8inx 8163 1 Initial initial JJ cord-010092-uftc8inx 8163 2 bacterial bacterial JJ cord-010092-uftc8inx 8163 3 titers titer NNS cord-010092-uftc8inx 8163 4 were be VBD cord-010092-uftc8inx 8163 5 5.9 5.9 CD cord-010092-uftc8inx 8163 6 - - SYM cord-010092-uftc8inx 8163 7 6.0 6.0 CD cord-010092-uftc8inx 8163 8 cfu cfu NN cord-010092-uftc8inx 8163 9 / / SYM cord-010092-uftc8inx 8163 10 mL. ml. NN cord-010092-uftc8inx 8164 1 Following follow VBG cord-010092-uftc8inx 8164 2 the the DT cord-010092-uftc8inx 8164 3 inactivation inactivation NN cord-010092-uftc8inx 8164 4 treatment treatment NN cord-010092-uftc8inx 8164 5 , , , cord-010092-uftc8inx 8164 6 no no DT cord-010092-uftc8inx 8164 7 viable viable JJ cord-010092-uftc8inx 8164 8 bacteria bacteria NNS cord-010092-uftc8inx 8164 9 were be VBD cord-010092-uftc8inx 8164 10 detected detect VBN cord-010092-uftc8inx 8164 11 by by IN cord-010092-uftc8inx 8164 12 plate plate NN cord-010092-uftc8inx 8164 13 culture culture NN cord-010092-uftc8inx 8164 14 . . . cord-010092-uftc8inx 8165 1 No no DT cord-010092-uftc8inx 8165 2 bacteria bacteria NNS cord-010092-uftc8inx 8165 3 were be VBD cord-010092-uftc8inx 8165 4 detected detect VBN cord-010092-uftc8inx 8165 5 after after IN cord-010092-uftc8inx 8165 6 3 3 CD cord-010092-uftc8inx 8165 7 , , , cord-010092-uftc8inx 8165 8 5 5 CD cord-010092-uftc8inx 8165 9 and and CC cord-010092-uftc8inx 8165 10 7 7 CD cord-010092-uftc8inx 8165 11 Days day NNS cord-010092-uftc8inx 8165 12 of of IN cord-010092-uftc8inx 8165 13 storage storage NN cord-010092-uftc8inx 8165 14 , , , cord-010092-uftc8inx 8165 15 corresponding correspond VBG cord-010092-uftc8inx 8165 16 to to IN cord-010092-uftc8inx 8165 17 > > $ cord-010092-uftc8inx 8165 18 5.9 5.9 CD cord-010092-uftc8inx 8165 19 log log NN cord-010092-uftc8inx 8165 20 10 10 CD cord-010092-uftc8inx 8165 21 inactivation inactivation NN cord-010092-uftc8inx 8165 22 of of IN cord-010092-uftc8inx 8165 23 both both DT cord-010092-uftc8inx 8165 24 bacterial bacterial JJ cord-010092-uftc8inx 8165 25 strains strain NNS cord-010092-uftc8inx 8165 26 . . . cord-010092-uftc8inx 8166 1 Performance performance NN cord-010092-uftc8inx 8166 2 of of IN cord-010092-uftc8inx 8166 3 the the DT cord-010092-uftc8inx 8166 4 INTERCEPT INTERCEPT NNP cord-010092-uftc8inx 8166 5 treatment treatment NN cord-010092-uftc8inx 8166 6 process process NN cord-010092-uftc8inx 8166 7 was be VBD cord-010092-uftc8inx 8166 8 confirmed confirm VBN cord-010092-uftc8inx 8166 9 in in IN cord-010092-uftc8inx 8166 10 the the DT cord-010092-uftc8inx 8166 11 sister sister NN cord-010092-uftc8inx 8166 12 PC pc NN cord-010092-uftc8inx 8166 13 unit unit NN cord-010092-uftc8inx 8166 14 as as IN cord-010092-uftc8inx 8166 15 evidenced evidence VBN cord-010092-uftc8inx 8166 16 by by IN cord-010092-uftc8inx 8166 17 levels level NNS cord-010092-uftc8inx 8166 18 of of IN cord-010092-uftc8inx 8166 19 amotosalen amotosalen NN cord-010092-uftc8inx 8166 20 and and CC cord-010092-uftc8inx 8166 21 its -PRON- PRP$ cord-010092-uftc8inx 8166 22 byproducts byproduct NNS cord-010092-uftc8inx 8166 23 characteristic characteristic NN cord-010092-uftc8inx 8166 24 of of IN cord-010092-uftc8inx 8166 25 INTERCEPT INTERCEPT NNP cord-010092-uftc8inx 8166 26 treatment treatment NN cord-010092-uftc8inx 8166 27 , , , cord-010092-uftc8inx 8166 28 as as RB cord-010092-uftc8inx 8166 29 well well RB cord-010092-uftc8inx 8166 30 as as IN cord-010092-uftc8inx 8166 31 by by IN cord-010092-uftc8inx 8166 32 review review NN cord-010092-uftc8inx 8166 33 of of IN cord-010092-uftc8inx 8166 34 the the DT cord-010092-uftc8inx 8166 35 process process NN cord-010092-uftc8inx 8166 36 documentation documentation NN cord-010092-uftc8inx 8166 37 . . . cord-010092-uftc8inx 8167 1 Summary Summary NNP cord-010092-uftc8inx 8167 2 / / SYM cord-010092-uftc8inx 8167 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 8167 4 : : : cord-010092-uftc8inx 8168 1 Amotosalen Amotosalen NNP cord-010092-uftc8inx 8168 2 / / SYM cord-010092-uftc8inx 8168 3 UVA UVA NNP cord-010092-uftc8inx 8168 4 effectively effectively RB cord-010092-uftc8inx 8168 5 inactivated inactivate VBD cord-010092-uftc8inx 8168 6 A. a. JJ cord-010092-uftc8inx 8168 7 baumanii baumanii NN cord-010092-uftc8inx 8168 8 and and CC cord-010092-uftc8inx 8168 9 S. S. NNP cord-010092-uftc8inx 8168 10 saprophyticus saprophyticus NN cord-010092-uftc8inx 8168 11 individually individually RB cord-010092-uftc8inx 8168 12 and and CC cord-010092-uftc8inx 8168 13 together together RB cord-010092-uftc8inx 8168 14 below below IN cord-010092-uftc8inx 8168 15 the the DT cord-010092-uftc8inx 8168 16 limit limit NN cord-010092-uftc8inx 8168 17 of of IN cord-010092-uftc8inx 8168 18 detection detection NN cord-010092-uftc8inx 8168 19 after after IN cord-010092-uftc8inx 8168 20 7 7 CD cord-010092-uftc8inx 8168 21 days day NNS cord-010092-uftc8inx 8168 22 storage storage NN cord-010092-uftc8inx 8168 23 . . . cord-010092-uftc8inx 8169 1 No no DT cord-010092-uftc8inx 8169 2 bacteria bacteria NNS cord-010092-uftc8inx 8169 3 in in IN cord-010092-uftc8inx 8169 4 the the DT cord-010092-uftc8inx 8169 5 sister sister NN cord-010092-uftc8inx 8169 6 PC pc NN cord-010092-uftc8inx 8169 7 by by IN cord-010092-uftc8inx 8169 8 Gram gram NN cord-010092-uftc8inx 8169 9 stain stain NN cord-010092-uftc8inx 8169 10 and and CC cord-010092-uftc8inx 8169 11 culture culture NN cord-010092-uftc8inx 8169 12 , , , cord-010092-uftc8inx 8169 13 and and CC cord-010092-uftc8inx 8169 14 the the DT cord-010092-uftc8inx 8169 15 presence presence NN cord-010092-uftc8inx 8169 16 of of IN cord-010092-uftc8inx 8169 17 amotosalen amotosalen VBN cord-010092-uftc8inx 8169 18 byproducts byproduct NNS cord-010092-uftc8inx 8169 19 suggested suggest VBD cord-010092-uftc8inx 8169 20 that that IN cord-010092-uftc8inx 8169 21 the the DT cord-010092-uftc8inx 8169 22 PC pc NN cord-010092-uftc8inx 8169 23 collection collection NN cord-010092-uftc8inx 8169 24 involved involve VBN cord-010092-uftc8inx 8169 25 in in IN cord-010092-uftc8inx 8169 26 the the DT cord-010092-uftc8inx 8169 27 septic septic JJ cord-010092-uftc8inx 8169 28 reaction reaction NN cord-010092-uftc8inx 8169 29 was be VBD cord-010092-uftc8inx 8169 30 sterile sterile JJ cord-010092-uftc8inx 8169 31 at at IN cord-010092-uftc8inx 8169 32 the the DT cord-010092-uftc8inx 8169 33 time time NN cord-010092-uftc8inx 8169 34 of of IN cord-010092-uftc8inx 8169 35 INTERCEPT INTERCEPT NNP cord-010092-uftc8inx 8169 36 treatment treatment NN cord-010092-uftc8inx 8169 37 and and CC cord-010092-uftc8inx 8169 38 was be VBD cord-010092-uftc8inx 8169 39 successfully successfully RB cord-010092-uftc8inx 8169 40 illuminated illuminate VBN cord-010092-uftc8inx 8169 41 . . . cord-010092-uftc8inx 8170 1 The the DT cord-010092-uftc8inx 8170 2 possibility possibility NN cord-010092-uftc8inx 8170 3 of of IN cord-010092-uftc8inx 8170 4 only only RB cord-010092-uftc8inx 8170 5 one one CD cord-010092-uftc8inx 8170 6 - - HYPH cord-010092-uftc8inx 8170 7 of of IN cord-010092-uftc8inx 8170 8 - - HYPH cord-010092-uftc8inx 8170 9 two two CD cord-010092-uftc8inx 8170 10 split split NN cord-010092-uftc8inx 8170 11 PC pc NN cord-010092-uftc8inx 8170 12 being be VBG cord-010092-uftc8inx 8170 13 contaminated contaminate VBN cord-010092-uftc8inx 8170 14 due due IN cord-010092-uftc8inx 8170 15 to to IN cord-010092-uftc8inx 8170 16 biofilm biofilm NN cord-010092-uftc8inx 8170 17 formation formation NN cord-010092-uftc8inx 8170 18 is be VBZ cord-010092-uftc8inx 8170 19 minimized minimize VBN cord-010092-uftc8inx 8170 20 in in IN cord-010092-uftc8inx 8170 21 the the DT cord-010092-uftc8inx 8170 22 INTERCEPT INTERCEPT NNP cord-010092-uftc8inx 8170 23 System system NN cord-010092-uftc8inx 8170 24 which which WDT cord-010092-uftc8inx 8170 25 decants decant VBZ cord-010092-uftc8inx 8170 26 platelets platelet NNS cord-010092-uftc8inx 8170 27 into into IN cord-010092-uftc8inx 8170 28 virgin virgin JJ cord-010092-uftc8inx 8170 29 storage storage NN cord-010092-uftc8inx 8170 30 bags bag NNS cord-010092-uftc8inx 8170 31 at at IN cord-010092-uftc8inx 8170 32 the the DT cord-010092-uftc8inx 8170 33 end end NN cord-010092-uftc8inx 8170 34 of of IN cord-010092-uftc8inx 8170 35 treatment treatment NN cord-010092-uftc8inx 8170 36 . . . cord-010092-uftc8inx 8171 1 Contamination contamination NN cord-010092-uftc8inx 8171 2 of of IN cord-010092-uftc8inx 8171 3 the the DT cord-010092-uftc8inx 8171 4 source source NN cord-010092-uftc8inx 8171 5 PC pc NN cord-010092-uftc8inx 8171 6 container container NN cord-010092-uftc8inx 8171 7 likely likely RB cord-010092-uftc8inx 8171 8 occurred occur VBD cord-010092-uftc8inx 8171 9 after after IN cord-010092-uftc8inx 8171 10 INTERCEPT INTERCEPT NNP cord-010092-uftc8inx 8171 11 treatment treatment NN cord-010092-uftc8inx 8171 12 , , , cord-010092-uftc8inx 8171 13 possibly possibly RB cord-010092-uftc8inx 8171 14 at at IN cord-010092-uftc8inx 8171 15 the the DT cord-010092-uftc8inx 8171 16 time time NN cord-010092-uftc8inx 8171 17 of of IN cord-010092-uftc8inx 8171 18 spiking spike VBG cord-010092-uftc8inx 8171 19 for for IN cord-010092-uftc8inx 8171 20 transfusion transfusion NN cord-010092-uftc8inx 8171 21 . . . cord-010092-uftc8inx 8172 1 Background background NN cord-010092-uftc8inx 8172 2 : : : cord-010092-uftc8inx 8173 1 Studies study NNS cord-010092-uftc8inx 8173 2 in in IN cord-010092-uftc8inx 8173 3 sub sub JJ cord-010092-uftc8inx 8173 4 - - JJ cord-010092-uftc8inx 8173 5 Saharan Saharan NNP cord-010092-uftc8inx 8173 6 Africa Africa NNP cord-010092-uftc8inx 8173 7 have have VBP cord-010092-uftc8inx 8173 8 documented document VBN cord-010092-uftc8inx 8173 9 bacterial bacterial JJ cord-010092-uftc8inx 8173 10 contamination contamination NN cord-010092-uftc8inx 8173 11 of of IN cord-010092-uftc8inx 8173 12 blood blood NN cord-010092-uftc8inx 8173 13 products product NNS cord-010092-uftc8inx 8173 14 for for IN cord-010092-uftc8inx 8173 15 transfusion transfusion NN cord-010092-uftc8inx 8173 16 varying vary VBG cord-010092-uftc8inx 8173 17 between between IN cord-010092-uftc8inx 8173 18 0,3%>17,5 0,3%>17,5 CD cord-010092-uftc8inx 8173 19 % % NN cord-010092-uftc8inx 8173 20 , , , cord-010092-uftc8inx 8173 21 up up IN cord-010092-uftc8inx 8173 22 to to TO cord-010092-uftc8inx 8173 23 5000 5000 CD cord-010092-uftc8inx 8173 24 times time NNS cord-010092-uftc8inx 8173 25 higher high JJR cord-010092-uftc8inx 8173 26 than than IN cord-010092-uftc8inx 8173 27 in in IN cord-010092-uftc8inx 8173 28 the the DT cord-010092-uftc8inx 8173 29 North North NNP cord-010092-uftc8inx 8173 30 . . . cord-010092-uftc8inx 8174 1 Published publish VBN cord-010092-uftc8inx 8174 2 data datum NNS cord-010092-uftc8inx 8174 3 from from IN cord-010092-uftc8inx 8174 4 Central Central NNP cord-010092-uftc8inx 8174 5 Africa Africa NNP cord-010092-uftc8inx 8174 6 are be VBP cord-010092-uftc8inx 8174 7 lacking lack VBG cord-010092-uftc8inx 8174 8 . . . cord-010092-uftc8inx 8175 1 Aims aim VBZ cord-010092-uftc8inx 8175 2 : : : cord-010092-uftc8inx 8176 1 The the DT cord-010092-uftc8inx 8176 2 aim aim NN cord-010092-uftc8inx 8176 3 of of IN cord-010092-uftc8inx 8176 4 this this DT cord-010092-uftc8inx 8176 5 study study NN cord-010092-uftc8inx 8176 6 was be VBD cord-010092-uftc8inx 8176 7 to to TO cord-010092-uftc8inx 8176 8 determine determine VB cord-010092-uftc8inx 8176 9 the the DT cord-010092-uftc8inx 8176 10 proportion proportion NN cord-010092-uftc8inx 8176 11 of of IN cord-010092-uftc8inx 8176 12 blood blood NN cord-010092-uftc8inx 8176 13 products product NNS cord-010092-uftc8inx 8176 14 contaminated contaminate VBN cord-010092-uftc8inx 8176 15 with with IN cord-010092-uftc8inx 8176 16 bacteria bacteria NNS cord-010092-uftc8inx 8176 17 in in IN cord-010092-uftc8inx 8176 18 three three CD cord-010092-uftc8inx 8176 19 hospitals hospital NNS cord-010092-uftc8inx 8176 20 in in IN cord-010092-uftc8inx 8176 21 the the DT cord-010092-uftc8inx 8176 22 Democratic Democratic NNP cord-010092-uftc8inx 8176 23 Republic Republic NNP cord-010092-uftc8inx 8176 24 of of IN cord-010092-uftc8inx 8176 25 the the DT cord-010092-uftc8inx 8176 26 Congo Congo NNP cord-010092-uftc8inx 8176 27 ( ( -LRB- cord-010092-uftc8inx 8176 28 DRC DRC NNP cord-010092-uftc8inx 8176 29 ) ) -RRB- cord-010092-uftc8inx 8176 30 . . . cord-010092-uftc8inx 8177 1 To to TO cord-010092-uftc8inx 8177 2 assure assure VB cord-010092-uftc8inx 8177 3 aseptic aseptic JJ cord-010092-uftc8inx 8177 4 sampling sampling NN cord-010092-uftc8inx 8177 5 , , , cord-010092-uftc8inx 8177 6 we -PRON- PRP cord-010092-uftc8inx 8177 7 used use VBD cord-010092-uftc8inx 8177 8 a a DT cord-010092-uftc8inx 8177 9 closed closed JJ cord-010092-uftc8inx 8177 10 system system NN cord-010092-uftc8inx 8177 11 of of IN cord-010092-uftc8inx 8177 12 sampling sampling NN cord-010092-uftc8inx 8177 13 bags bag NNS cord-010092-uftc8inx 8177 14 . . . cord-010092-uftc8inx 8178 1 In in IN cord-010092-uftc8inx 8178 2 addition addition NN cord-010092-uftc8inx 8178 3 to to IN cord-010092-uftc8inx 8178 4 the the DT cord-010092-uftc8inx 8178 5 presence presence NN cord-010092-uftc8inx 8178 6 of of IN cord-010092-uftc8inx 8178 7 contamination contamination NN cord-010092-uftc8inx 8178 8 , , , cord-010092-uftc8inx 8178 9 we -PRON- PRP cord-010092-uftc8inx 8178 10 assessed assess VBD cord-010092-uftc8inx 8178 11 semi semi JJ cord-010092-uftc8inx 8178 12 - - JJ cord-010092-uftc8inx 8178 13 quantitative quantitative JJ cord-010092-uftc8inx 8178 14 colony colony NN cord-010092-uftc8inx 8178 15 counts count NNS cord-010092-uftc8inx 8178 16 . . . cord-010092-uftc8inx 8179 1 Methods method NNS cord-010092-uftc8inx 8179 2 : : : cord-010092-uftc8inx 8179 3 From from IN cord-010092-uftc8inx 8179 4 July July NNP cord-010092-uftc8inx 8179 5 to to IN cord-010092-uftc8inx 8179 6 December December NNP cord-010092-uftc8inx 8179 7 2018 2018 CD cord-010092-uftc8inx 8179 8 , , , cord-010092-uftc8inx 8179 9 a a DT cord-010092-uftc8inx 8179 10 total total NN cord-010092-uftc8inx 8179 11 of of IN cord-010092-uftc8inx 8179 12 2411 2411 CD cord-010092-uftc8inx 8179 13 blood blood NN cord-010092-uftc8inx 8179 14 products product NNS cord-010092-uftc8inx 8179 15 were be VBD cord-010092-uftc8inx 8179 16 sampled sample VBN cord-010092-uftc8inx 8179 17 , , , cord-010092-uftc8inx 8179 18 of of IN cord-010092-uftc8inx 8179 19 which which WDT cord-010092-uftc8inx 8179 20 979 979 CD cord-010092-uftc8inx 8179 21 in in IN cord-010092-uftc8inx 8179 22 Hôpital Hôpital NNP cord-010092-uftc8inx 8179 23 Provincial Provincial NNP cord-010092-uftc8inx 8179 24 G G NNP cord-010092-uftc8inx 8179 25 en en FW cord-010092-uftc8inx 8179 26 eral eral FW cord-010092-uftc8inx 8179 27 de de FW cord-010092-uftc8inx 8179 28 R R NNP cord-010092-uftc8inx 8179 29 ef ef NN cord-010092-uftc8inx 8179 30 erence erence NN cord-010092-uftc8inx 8179 31 , , , cord-010092-uftc8inx 8179 32 Kinshasa Kinshasa NNP cord-010092-uftc8inx 8179 33 ( ( -LRB- cord-010092-uftc8inx 8179 34 HPGRK HPGRK NNP cord-010092-uftc8inx 8179 35 ) ) -RRB- cord-010092-uftc8inx 8179 36 , , , cord-010092-uftc8inx 8179 37 662 662 CD cord-010092-uftc8inx 8179 38 in in IN cord-010092-uftc8inx 8179 39 Hôpital Hôpital NNP cord-010092-uftc8inx 8179 40 P P NNP cord-010092-uftc8inx 8179 41 ediatrique ediatrique NN cord-010092-uftc8inx 8179 42 Kalembe Kalembe NNP cord-010092-uftc8inx 8179 43 Lembe Lembe NNP cord-010092-uftc8inx 8179 44 , , , cord-010092-uftc8inx 8179 45 Kinshasa Kinshasa NNP cord-010092-uftc8inx 8179 46 ( ( -LRB- cord-010092-uftc8inx 8179 47 HPKLL HPKLL NNP cord-010092-uftc8inx 8179 48 ) ) -RRB- cord-010092-uftc8inx 8179 49 and and CC cord-010092-uftc8inx 8179 50 770 770 CD cord-010092-uftc8inx 8179 51 in in IN cord-010092-uftc8inx 8179 52 Hôpital Hôpital NNP cord-010092-uftc8inx 8179 53 Saint Saint NNP cord-010092-uftc8inx 8179 54 - - HYPH cord-010092-uftc8inx 8179 55 Luc Luc NNP cord-010092-uftc8inx 8179 56 , , , cord-010092-uftc8inx 8179 57 Kisantu Kisantu NNP cord-010092-uftc8inx 8179 58 ( ( -LRB- cord-010092-uftc8inx 8179 59 HSLK HSLK NNP cord-010092-uftc8inx 8179 60 ) ) -RRB- cord-010092-uftc8inx 8179 61 . . . cord-010092-uftc8inx 8180 1 After after IN cord-010092-uftc8inx 8180 2 compatibilization compatibilization NN cord-010092-uftc8inx 8180 3 of of IN cord-010092-uftc8inx 8180 4 blood blood NN cord-010092-uftc8inx 8180 5 products product NNS cord-010092-uftc8inx 8180 6 , , , cord-010092-uftc8inx 8180 7 16 16 CD cord-010092-uftc8inx 8180 8 ml ml NNS cord-010092-uftc8inx 8180 9 of of IN cord-010092-uftc8inx 8180 10 blood blood NN cord-010092-uftc8inx 8180 11 was be VBD cord-010092-uftc8inx 8180 12 transferred transfer VBN cord-010092-uftc8inx 8180 13 from from IN cord-010092-uftc8inx 8180 14 the the DT cord-010092-uftc8inx 8180 15 primary primary JJ cord-010092-uftc8inx 8180 16 blood blood NN cord-010092-uftc8inx 8180 17 bag bag NN cord-010092-uftc8inx 8180 18 to to IN cord-010092-uftc8inx 8180 19 an an DT cord-010092-uftc8inx 8180 20 attached attach VBN cord-010092-uftc8inx 8180 21 sampling sampling NN cord-010092-uftc8inx 8180 22 bag bag NN cord-010092-uftc8inx 8180 23 . . . cord-010092-uftc8inx 8181 1 Sampling sampling NN cord-010092-uftc8inx 8181 2 bags bag NNS cord-010092-uftc8inx 8181 3 were be VBD cord-010092-uftc8inx 8181 4 sealed seal VBN cord-010092-uftc8inx 8181 5 off off RP cord-010092-uftc8inx 8181 6 , , , cord-010092-uftc8inx 8181 7 stored store VBN cord-010092-uftc8inx 8181 8 in in IN cord-010092-uftc8inx 8181 9 the the DT cord-010092-uftc8inx 8181 10 fridge fridge NN cord-010092-uftc8inx 8181 11 and and CC cord-010092-uftc8inx 8181 12 transported transport VBD cord-010092-uftc8inx 8181 13 once once RB cord-010092-uftc8inx 8181 14 daily daily RB cord-010092-uftc8inx 8181 15 to to IN cord-010092-uftc8inx 8181 16 the the DT cord-010092-uftc8inx 8181 17 bacteriology bacteriology NN cord-010092-uftc8inx 8181 18 laboratory laboratory NN cord-010092-uftc8inx 8181 19 . . . cord-010092-uftc8inx 8182 1 Using use VBG cord-010092-uftc8inx 8182 2 the the DT cord-010092-uftc8inx 8182 3 adapter adapter NN cord-010092-uftc8inx 8182 4 connected connect VBN cord-010092-uftc8inx 8182 5 to to IN cord-010092-uftc8inx 8182 6 the the DT cord-010092-uftc8inx 8182 7 sampling sampling NN cord-010092-uftc8inx 8182 8 bag bag NN cord-010092-uftc8inx 8182 9 , , , cord-010092-uftc8inx 8182 10 4 4 CD cord-010092-uftc8inx 8182 11 ml ml NNS cord-010092-uftc8inx 8182 12 of of IN cord-010092-uftc8inx 8182 13 blood blood NN cord-010092-uftc8inx 8182 14 was be VBD cord-010092-uftc8inx 8182 15 inoculated inoculate VBN cord-010092-uftc8inx 8182 16 in in IN cord-010092-uftc8inx 8182 17 a a DT cord-010092-uftc8inx 8182 18 blood blood NN cord-010092-uftc8inx 8182 19 culture culture NN cord-010092-uftc8inx 8182 20 ( ( -LRB- cord-010092-uftc8inx 8182 21 BacTAlertPF BacTAlertPF NNP cord-010092-uftc8inx 8182 22 , , , cord-010092-uftc8inx 8182 23 bioM bioM NNP cord-010092-uftc8inx 8182 24 erieux erieux NNP cord-010092-uftc8inx 8182 25 ) ) -RRB- cord-010092-uftc8inx 8182 26 and and CC cord-010092-uftc8inx 8182 27 incubated incubate VBN cord-010092-uftc8inx 8182 28 at at IN cord-010092-uftc8inx 8182 29 35 35 CD cord-010092-uftc8inx 8182 30 ° ° NN cord-010092-uftc8inx 8182 31 C c NN cord-010092-uftc8inx 8182 32 for for IN cord-010092-uftc8inx 8182 33 7 7 CD cord-010092-uftc8inx 8182 34 days day NNS cord-010092-uftc8inx 8182 35 . . . cord-010092-uftc8inx 8183 1 Cultures culture NNS cord-010092-uftc8inx 8183 2 were be VBD cord-010092-uftc8inx 8183 3 checked check VBN cord-010092-uftc8inx 8183 4 daily daily RB cord-010092-uftc8inx 8183 5 for for IN cord-010092-uftc8inx 8183 6 signs sign NNS cord-010092-uftc8inx 8183 7 of of IN cord-010092-uftc8inx 8183 8 growth growth NN cord-010092-uftc8inx 8183 9 . . . cord-010092-uftc8inx 8184 1 In in IN cord-010092-uftc8inx 8184 2 addition addition NN cord-010092-uftc8inx 8184 3 , , , cord-010092-uftc8inx 8184 4 2 2 CD cord-010092-uftc8inx 8184 5 ml ml NNS cord-010092-uftc8inx 8184 6 of of IN cord-010092-uftc8inx 8184 7 blood blood NN cord-010092-uftc8inx 8184 8 was be VBD cord-010092-uftc8inx 8184 9 equally equally RB cord-010092-uftc8inx 8184 10 distributed distribute VBN cord-010092-uftc8inx 8184 11 on on IN cord-010092-uftc8inx 8184 12 the the DT cord-010092-uftc8inx 8184 13 CLED CLED NNP cord-010092-uftc8inx 8184 14 and and CC cord-010092-uftc8inx 8184 15 MacConkey MacConkey NNP cord-010092-uftc8inx 8184 16 agar agar NN cord-010092-uftc8inx 8184 17 - - HYPH cord-010092-uftc8inx 8184 18 coated coat VBN cord-010092-uftc8inx 8184 19 sides side NNS cord-010092-uftc8inx 8184 20 of of IN cord-010092-uftc8inx 8184 21 a a DT cord-010092-uftc8inx 8184 22 dipslide dipslide NN cord-010092-uftc8inx 8184 23 ( ( -LRB- cord-010092-uftc8inx 8184 24 MEUS MEUS NNP cord-010092-uftc8inx 8184 25 s.r.l s.r.l JJ cord-010092-uftc8inx 8184 26 . . . cord-010092-uftc8inx 8184 27 ) ) -RRB- cord-010092-uftc8inx 8184 28 . . . cord-010092-uftc8inx 8185 1 Dipslides dipslide NNS cord-010092-uftc8inx 8185 2 were be VBD cord-010092-uftc8inx 8185 3 incubated incubate VBN cord-010092-uftc8inx 8185 4 48 48 CD cord-010092-uftc8inx 8185 5 h h NN cord-010092-uftc8inx 8185 6 for for IN cord-010092-uftc8inx 8185 7 semi semi JJ cord-010092-uftc8inx 8185 8 - - JJ cord-010092-uftc8inx 8185 9 quantitative quantitative JJ cord-010092-uftc8inx 8185 10 culture culture NN cord-010092-uftc8inx 8185 11 , , , cord-010092-uftc8inx 8185 12 expressed express VBN cord-010092-uftc8inx 8185 13 as as IN cord-010092-uftc8inx 8185 14 colony colony NN cord-010092-uftc8inx 8185 15 - - HYPH cord-010092-uftc8inx 8185 16 formingunits formingunit NNS cord-010092-uftc8inx 8185 17 ( ( -LRB- cord-010092-uftc8inx 8185 18 CFU CFU NNP cord-010092-uftc8inx 8185 19 ) ) -RRB- cord-010092-uftc8inx 8185 20 per per IN cord-010092-uftc8inx 8185 21 ml ml NN cord-010092-uftc8inx 8185 22 . . . cord-010092-uftc8inx 8186 1 In in IN cord-010092-uftc8inx 8186 2 case case NN cord-010092-uftc8inx 8186 3 of of IN cord-010092-uftc8inx 8186 4 blood blood NN cord-010092-uftc8inx 8186 5 culture culture NN cord-010092-uftc8inx 8186 6 growth growth NN cord-010092-uftc8inx 8186 7 , , , cord-010092-uftc8inx 8186 8 bacteria bacteria NNS cord-010092-uftc8inx 8186 9 were be VBD cord-010092-uftc8inx 8186 10 identified identify VBN cord-010092-uftc8inx 8186 11 and and CC cord-010092-uftc8inx 8186 12 a a DT cord-010092-uftc8inx 8186 13 second second JJ cord-010092-uftc8inx 8186 14 blood blood NN cord-010092-uftc8inx 8186 15 culture culture NN cord-010092-uftc8inx 8186 16 was be VBD cord-010092-uftc8inx 8186 17 inoculated inoculate VBN cord-010092-uftc8inx 8186 18 to to TO cord-010092-uftc8inx 8186 19 exclude exclude VB cord-010092-uftc8inx 8186 20 contamination contamination NN cord-010092-uftc8inx 8186 21 during during IN cord-010092-uftc8inx 8186 22 processing processing NN cord-010092-uftc8inx 8186 23 . . . cord-010092-uftc8inx 8187 1 Bacteria Bacteria NNS cord-010092-uftc8inx 8187 2 grown grow VBN cord-010092-uftc8inx 8187 3 on on IN cord-010092-uftc8inx 8187 4 semi semi JJ cord-010092-uftc8inx 8187 5 - - JJ cord-010092-uftc8inx 8187 6 quantitative quantitative JJ cord-010092-uftc8inx 8187 7 culture culture NN cord-010092-uftc8inx 8187 8 were be VBD cord-010092-uftc8inx 8187 9 also also RB cord-010092-uftc8inx 8187 10 identified identify VBN cord-010092-uftc8inx 8187 11 . . . cord-010092-uftc8inx 8188 1 Results result NNS cord-010092-uftc8inx 8188 2 : : : cord-010092-uftc8inx 8189 1 A a DT cord-010092-uftc8inx 8189 2 total total NN cord-010092-uftc8inx 8189 3 of of IN cord-010092-uftc8inx 8189 4 1.6 1.6 CD cord-010092-uftc8inx 8189 5 % % NN cord-010092-uftc8inx 8189 6 ( ( -LRB- cord-010092-uftc8inx 8189 7 39/2411 39/2411 LS cord-010092-uftc8inx 8189 8 ) ) -RRB- cord-010092-uftc8inx 8189 9 of of IN cord-010092-uftc8inx 8189 10 whole whole JJ cord-010092-uftc8inx 8189 11 blood blood NN cord-010092-uftc8inx 8189 12 and and CC cord-010092-uftc8inx 8189 13 red red JJ cord-010092-uftc8inx 8189 14 cell cell NN cord-010092-uftc8inx 8189 15 concentrates concentrate NNS cord-010092-uftc8inx 8189 16 were be VBD cord-010092-uftc8inx 8189 17 contaminated contaminate VBN cord-010092-uftc8inx 8189 18 with with IN cord-010092-uftc8inx 8189 19 bacteria bacteria NNS cord-010092-uftc8inx 8189 20 . . . cord-010092-uftc8inx 8190 1 In in IN cord-010092-uftc8inx 8190 2 HPGRK HPGRK NNP cord-010092-uftc8inx 8190 3 , , , cord-010092-uftc8inx 8190 4 2.7 2.7 CD cord-010092-uftc8inx 8190 5 % % NN cord-010092-uftc8inx 8190 6 ( ( -LRB- cord-010092-uftc8inx 8190 7 26/979 26/979 CD cord-010092-uftc8inx 8190 8 ) ) -RRB- cord-010092-uftc8inx 8190 9 of of IN cord-010092-uftc8inx 8190 10 blood blood NN cord-010092-uftc8inx 8190 11 products product NNS cord-010092-uftc8inx 8190 12 were be VBD cord-010092-uftc8inx 8190 13 contaminated contaminate VBN cord-010092-uftc8inx 8190 14 , , , cord-010092-uftc8inx 8190 15 in in IN cord-010092-uftc8inx 8190 16 HPKLL HPKLL NNP cord-010092-uftc8inx 8190 17 1.5 1.5 CD cord-010092-uftc8inx 8190 18 % % NN cord-010092-uftc8inx 8190 19 ( ( -LRB- cord-010092-uftc8inx 8190 20 10/662 10/662 CD cord-010092-uftc8inx 8190 21 ) ) -RRB- cord-010092-uftc8inx 8190 22 and and CC cord-010092-uftc8inx 8190 23 in in IN cord-010092-uftc8inx 8190 24 HSLK HSLK NNP cord-010092-uftc8inx 8190 25 0.4 0.4 CD cord-010092-uftc8inx 8190 26 % % NN cord-010092-uftc8inx 8190 27 ( ( -LRB- cord-010092-uftc8inx 8190 28 3/770 3/770 CD cord-010092-uftc8inx 8190 29 ) ) -RRB- cord-010092-uftc8inx 8190 30 . . . cord-010092-uftc8inx 8191 1 The the DT cord-010092-uftc8inx 8191 2 proportion proportion NN cord-010092-uftc8inx 8191 3 of of IN cord-010092-uftc8inx 8191 4 contaminated contaminated JJ cord-010092-uftc8inx 8191 5 blood blood NN cord-010092-uftc8inx 8191 6 products product NNS cord-010092-uftc8inx 8191 7 was be VBD cord-010092-uftc8inx 8191 8 significantly significantly RB cord-010092-uftc8inx 8191 9 higher high JJR cord-010092-uftc8inx 8191 10 in in IN cord-010092-uftc8inx 8191 11 HPGRK HPGRK NNS cord-010092-uftc8inx 8191 12 compared compare VBN cord-010092-uftc8inx 8191 13 to to IN cord-010092-uftc8inx 8191 14 HSLK HSLK NNP cord-010092-uftc8inx 8191 15 ( ( -LRB- cord-010092-uftc8inx 8191 16 P p NN cord-010092-uftc8inx 8191 17 = = SYM cord-010092-uftc8inx 8191 18 0.00047 0.00047 CD cord-010092-uftc8inx 8191 19 ) ) -RRB- cord-010092-uftc8inx 8191 20 . . . cord-010092-uftc8inx 8192 1 There there EX cord-010092-uftc8inx 8192 2 was be VBD cord-010092-uftc8inx 8192 3 no no DT cord-010092-uftc8inx 8192 4 significant significant JJ cord-010092-uftc8inx 8192 5 difference difference NN cord-010092-uftc8inx 8192 6 between between IN cord-010092-uftc8inx 8192 7 the the DT cord-010092-uftc8inx 8192 8 other other JJ cord-010092-uftc8inx 8192 9 sites site NNS cord-010092-uftc8inx 8192 10 ( ( -LRB- cord-010092-uftc8inx 8192 11 P p NN cord-010092-uftc8inx 8192 12 = = SYM cord-010092-uftc8inx 8192 13 0.051 0.051 CD cord-010092-uftc8inx 8192 14 and and CC cord-010092-uftc8inx 8192 15 P p NN cord-010092-uftc8inx 8192 16 = = SYM cord-010092-uftc8inx 8192 17 0.12 0.12 CD cord-010092-uftc8inx 8192 18 ) ) -RRB- cord-010092-uftc8inx 8192 19 . . . cord-010092-uftc8inx 8193 1 Majority majority NN cord-010092-uftc8inx 8193 2 of of IN cord-010092-uftc8inx 8193 3 isolated isolate VBN cord-010092-uftc8inx 8193 4 bacterial bacterial JJ cord-010092-uftc8inx 8193 5 species specie NNS cord-010092-uftc8inx 8193 6 were be VBD cord-010092-uftc8inx 8193 7 coagulase coagulase NN cord-010092-uftc8inx 8193 8 - - HYPH cord-010092-uftc8inx 8193 9 negative negative JJ cord-010092-uftc8inx 8193 10 Staphylococcus Staphylococcus NNP cord-010092-uftc8inx 8193 11 spp./Micrococcus spp./micrococcus NN cord-010092-uftc8inx 8193 12 spp spp NNS cord-010092-uftc8inx 8193 13 . . . cord-010092-uftc8inx 8194 1 ( ( -LRB- cord-010092-uftc8inx 8194 2 46.7 46.7 CD cord-010092-uftc8inx 8194 3 % % NN cord-010092-uftc8inx 8194 4 ) ) -RRB- cord-010092-uftc8inx 8194 5 and and CC cord-010092-uftc8inx 8194 6 Bacillus Bacillus NNP cord-010092-uftc8inx 8194 7 spp spp NNS cord-010092-uftc8inx 8194 8 . . . cord-010092-uftc8inx 8195 1 ( ( -LRB- cord-010092-uftc8inx 8195 2 33.3 33.3 CD cord-010092-uftc8inx 8195 3 % % NN cord-010092-uftc8inx 8195 4 ) ) -RRB- cord-010092-uftc8inx 8195 5 . . . cord-010092-uftc8inx 8196 1 The the DT cord-010092-uftc8inx 8196 2 remaining remain VBG cord-010092-uftc8inx 8196 3 20 20 CD cord-010092-uftc8inx 8196 4 % % NN cord-010092-uftc8inx 8196 5 of of IN cord-010092-uftc8inx 8196 6 bacterial bacterial JJ cord-010092-uftc8inx 8196 7 isolates isolate NNS cord-010092-uftc8inx 8196 8 were be VBD cord-010092-uftc8inx 8196 9 identified identify VBN cord-010092-uftc8inx 8196 10 as as IN cord-010092-uftc8inx 8196 11 non non JJ cord-010092-uftc8inx 8196 12 - - JJ cord-010092-uftc8inx 8196 13 fermentative fermentative JJ cord-010092-uftc8inx 8196 14 Gram gram NN cord-010092-uftc8inx 8196 15 - - HYPH cord-010092-uftc8inx 8196 16 negative negative JJ cord-010092-uftc8inx 8196 17 rods rod NNS cord-010092-uftc8inx 8196 18 , , , cord-010092-uftc8inx 8196 19 Klebsiella Klebsiella NNP cord-010092-uftc8inx 8196 20 pneumoniae pneumoniae NN cord-010092-uftc8inx 8196 21 , , , cord-010092-uftc8inx 8196 22 Staphylococcus Staphylococcus NNP cord-010092-uftc8inx 8196 23 aureus aureus NN cord-010092-uftc8inx 8196 24 , , , cord-010092-uftc8inx 8196 25 mould mould NN cord-010092-uftc8inx 8196 26 , , , cord-010092-uftc8inx 8196 27 Listeria Listeria NNP cord-010092-uftc8inx 8196 28 spp spp NNP cord-010092-uftc8inx 8196 29 . . . cord-010092-uftc8inx 8197 1 , , , cord-010092-uftc8inx 8198 1 Corynebacterium corynebacterium NN cord-010092-uftc8inx 8198 2 spp./Coryneform spp./coryneform CD cord-010092-uftc8inx 8198 3 bacteria bacteria NNS cord-010092-uftc8inx 8198 4 . . . cord-010092-uftc8inx 8199 1 The the DT cord-010092-uftc8inx 8199 2 concentration concentration NN cord-010092-uftc8inx 8199 3 of of IN cord-010092-uftc8inx 8199 4 all all DT cord-010092-uftc8inx 8199 5 isolated isolate VBN cord-010092-uftc8inx 8199 6 bacteria bacteria NNS cord-010092-uftc8inx 8199 7 was be VBD cord-010092-uftc8inx 8199 8 lower low JJR cord-010092-uftc8inx 8199 9 than than IN cord-010092-uftc8inx 8199 10 10³ 10³ CD cord-010092-uftc8inx 8199 11 CFU CFU NNP cord-010092-uftc8inx 8199 12 / / SYM cord-010092-uftc8inx 8199 13 ml ml XX cord-010092-uftc8inx 8199 14 , , , cord-010092-uftc8inx 8199 15 except except IN cord-010092-uftc8inx 8199 16 for for IN cord-010092-uftc8inx 8199 17 one one CD cord-010092-uftc8inx 8199 18 coagulase coagulase NN cord-010092-uftc8inx 8199 19 - - HYPH cord-010092-uftc8inx 8199 20 negative negative JJ cord-010092-uftc8inx 8199 21 Staphylococcus Staphylococcus NNP cord-010092-uftc8inx 8199 22 spp spp NNS cord-010092-uftc8inx 8199 23 . . . cord-010092-uftc8inx 8200 1 found find VBN cord-010092-uftc8inx 8200 2 in in IN cord-010092-uftc8inx 8200 3 HPGRK HPGRK NNP cord-010092-uftc8inx 8200 4 at at IN cord-010092-uftc8inx 8200 5 10³ 10³ CD cord-010092-uftc8inx 8200 6 CFU CFU NNP cord-010092-uftc8inx 8200 7 / / SYM cord-010092-uftc8inx 8200 8 ml ml NN cord-010092-uftc8inx 8200 9 . . . cord-010092-uftc8inx 8201 1 Summary Summary NNP cord-010092-uftc8inx 8201 2 / / SYM cord-010092-uftc8inx 8201 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 8201 4 : : : cord-010092-uftc8inx 8202 1 To to IN cord-010092-uftc8inx 8202 2 our -PRON- PRP$ cord-010092-uftc8inx 8202 3 knowledge knowledge NN cord-010092-uftc8inx 8202 4 , , , cord-010092-uftc8inx 8202 5 we -PRON- PRP cord-010092-uftc8inx 8202 6 were be VBD cord-010092-uftc8inx 8202 7 the the DT cord-010092-uftc8inx 8202 8 first first JJ cord-010092-uftc8inx 8202 9 to to TO cord-010092-uftc8inx 8202 10 reach reach VB cord-010092-uftc8inx 8202 11 a a DT cord-010092-uftc8inx 8202 12 sample sample NN cord-010092-uftc8inx 8202 13 size size NN cord-010092-uftc8inx 8202 14 of of IN cord-010092-uftc8inx 8202 15 more more JJR cord-010092-uftc8inx 8202 16 than than IN cord-010092-uftc8inx 8202 17 2000 2000 CD cord-010092-uftc8inx 8202 18 blood blood NN cord-010092-uftc8inx 8202 19 products product NNS cord-010092-uftc8inx 8202 20 for for IN cord-010092-uftc8inx 8202 21 bacterial bacterial JJ cord-010092-uftc8inx 8202 22 culture culture NN cord-010092-uftc8inx 8202 23 and and CC cord-010092-uftc8inx 8202 24 the the DT cord-010092-uftc8inx 8202 25 first first JJ cord-010092-uftc8inx 8202 26 to to TO cord-010092-uftc8inx 8202 27 use use VB cord-010092-uftc8inx 8202 28 a a DT cord-010092-uftc8inx 8202 29 closed closed JJ cord-010092-uftc8inx 8202 30 system system NN cord-010092-uftc8inx 8202 31 of of IN cord-010092-uftc8inx 8202 32 sampling sampling NN cord-010092-uftc8inx 8202 33 bags bag NNS cord-010092-uftc8inx 8202 34 in in IN cord-010092-uftc8inx 8202 35 sub sub JJ cord-010092-uftc8inx 8202 36 - - JJ cord-010092-uftc8inx 8202 37 Saharan Saharan NNP cord-010092-uftc8inx 8202 38 Africa Africa NNP cord-010092-uftc8inx 8202 39 , , , cord-010092-uftc8inx 8202 40 which which WDT cord-010092-uftc8inx 8202 41 guarantees guarantee VBZ cord-010092-uftc8inx 8202 42 aseptic aseptic JJ cord-010092-uftc8inx 8202 43 sampling sampling NN cord-010092-uftc8inx 8202 44 of of IN cord-010092-uftc8inx 8202 45 blood blood NN cord-010092-uftc8inx 8202 46 cultures culture NNS cord-010092-uftc8inx 8202 47 . . . cord-010092-uftc8inx 8203 1 This this DT cord-010092-uftc8inx 8203 2 might may MD cord-010092-uftc8inx 8203 3 explain explain VB cord-010092-uftc8inx 8203 4 the the DT cord-010092-uftc8inx 8203 5 low low JJ cord-010092-uftc8inx 8203 6 bacterial bacterial JJ cord-010092-uftc8inx 8203 7 contamination contamination NN cord-010092-uftc8inx 8203 8 rate rate NN cord-010092-uftc8inx 8203 9 ( ( -LRB- cord-010092-uftc8inx 8203 10 1.6 1.6 CD cord-010092-uftc8inx 8203 11 % % NN cord-010092-uftc8inx 8203 12 ) ) -RRB- cord-010092-uftc8inx 8203 13 of of IN cord-010092-uftc8inx 8203 14 blood blood NN cord-010092-uftc8inx 8203 15 products product NNS cord-010092-uftc8inx 8203 16 in in IN cord-010092-uftc8inx 8203 17 three three CD cord-010092-uftc8inx 8203 18 hospitals hospital NNS cord-010092-uftc8inx 8203 19 in in IN cord-010092-uftc8inx 8203 20 DRC DRC NNP cord-010092-uftc8inx 8203 21 compared compare VBN cord-010092-uftc8inx 8203 22 to to IN cord-010092-uftc8inx 8203 23 previous previous JJ cord-010092-uftc8inx 8203 24 studies study NNS cord-010092-uftc8inx 8203 25 in in IN cord-010092-uftc8inx 8203 26 other other JJ cord-010092-uftc8inx 8203 27 sub sub JJ cord-010092-uftc8inx 8203 28 - - JJ cord-010092-uftc8inx 8203 29 Saharan saharan JJ cord-010092-uftc8inx 8203 30 African african JJ cord-010092-uftc8inx 8203 31 countries country NNS cord-010092-uftc8inx 8203 32 . . . cord-010092-uftc8inx 8204 1 Moreover moreover RB cord-010092-uftc8inx 8204 2 , , , cord-010092-uftc8inx 8204 3 bacterial bacterial JJ cord-010092-uftc8inx 8204 4 concentrations concentration NNS cord-010092-uftc8inx 8204 5 in in IN cord-010092-uftc8inx 8204 6 the the DT cord-010092-uftc8inx 8204 7 contaminated contaminate VBN cord-010092-uftc8inx 8204 8 blood blood NN cord-010092-uftc8inx 8204 9 products product NNS cord-010092-uftc8inx 8204 10 were be VBD cord-010092-uftc8inx 8204 11 low low JJ cord-010092-uftc8inx 8204 12 ( ( -LRB- cord-010092-uftc8inx 8204 13 < < NNP cord-010092-uftc8inx 8204 14 10³ 10³ CD cord-010092-uftc8inx 8204 15 CFU CFU NNP cord-010092-uftc8inx 8204 16 / / SYM cord-010092-uftc8inx 8204 17 ml ml NN cord-010092-uftc8inx 8204 18 ) ) -RRB- cord-010092-uftc8inx 8204 19 . . . cord-010092-uftc8inx 8205 1 The the DT cord-010092-uftc8inx 8205 2 different different JJ cord-010092-uftc8inx 8205 3 proportions proportion NNS cord-010092-uftc8inx 8205 4 of of IN cord-010092-uftc8inx 8205 5 contamination contamination NN cord-010092-uftc8inx 8205 6 between between IN cord-010092-uftc8inx 8205 7 study study NN cord-010092-uftc8inx 8205 8 sites site NNS cord-010092-uftc8inx 8205 9 suggest suggest VBP cord-010092-uftc8inx 8205 10 that that IN cord-010092-uftc8inx 8205 11 different different JJ cord-010092-uftc8inx 8205 12 environments environment NNS cord-010092-uftc8inx 8205 13 and and CC cord-010092-uftc8inx 8205 14 practices practice NNS cord-010092-uftc8inx 8205 15 play play VBP cord-010092-uftc8inx 8205 16 a a DT cord-010092-uftc8inx 8205 17 role role NN cord-010092-uftc8inx 8205 18 in in IN cord-010092-uftc8inx 8205 19 the the DT cord-010092-uftc8inx 8205 20 risk risk NN cord-010092-uftc8inx 8205 21 for for IN cord-010092-uftc8inx 8205 22 bacterial bacterial JJ cord-010092-uftc8inx 8205 23 contamination contamination NN cord-010092-uftc8inx 8205 24 . . . cord-010092-uftc8inx 8206 1 Background background NN cord-010092-uftc8inx 8206 2 : : : cord-010092-uftc8inx 8207 1 Although although IN cord-010092-uftc8inx 8207 2 the the DT cord-010092-uftc8inx 8207 3 screening screening NN cord-010092-uftc8inx 8207 4 of of IN cord-010092-uftc8inx 8207 5 the the DT cord-010092-uftc8inx 8207 6 Treponema Treponema NNP cord-010092-uftc8inx 8207 7 pallidum pallidum NN cord-010092-uftc8inx 8207 8 ( ( -LRB- cord-010092-uftc8inx 8207 9 Tp tp NN cord-010092-uftc8inx 8207 10 ) ) -RRB- cord-010092-uftc8inx 8207 11 is be VBZ cord-010092-uftc8inx 8207 12 mandatory mandatory JJ cord-010092-uftc8inx 8207 13 in in IN cord-010092-uftc8inx 8207 14 blood blood NN cord-010092-uftc8inx 8207 15 donations donation NNS cord-010092-uftc8inx 8207 16 , , , cord-010092-uftc8inx 8207 17 its -PRON- PRP$ cord-010092-uftc8inx 8207 18 necessity necessity NN cord-010092-uftc8inx 8207 19 is be VBZ cord-010092-uftc8inx 8207 20 controversial controversial JJ cord-010092-uftc8inx 8207 21 , , , cord-010092-uftc8inx 8207 22 because because IN cord-010092-uftc8inx 8207 23 there there EX cord-010092-uftc8inx 8207 24 have have VBP cord-010092-uftc8inx 8207 25 been be VBN cord-010092-uftc8inx 8207 26 no no DT cord-010092-uftc8inx 8207 27 transmissions transmission NNS cord-010092-uftc8inx 8207 28 by by IN cord-010092-uftc8inx 8207 29 blood blood NN cord-010092-uftc8inx 8207 30 products product NNS cord-010092-uftc8inx 8207 31 documented document VBN cord-010092-uftc8inx 8207 32 in in IN cord-010092-uftc8inx 8207 33 the the DT cord-010092-uftc8inx 8207 34 developed develop VBN cord-010092-uftc8inx 8207 35 countries country NNS cord-010092-uftc8inx 8207 36 in in IN cord-010092-uftc8inx 8207 37 the the DT cord-010092-uftc8inx 8207 38 last last JJ cord-010092-uftc8inx 8207 39 few few JJ cord-010092-uftc8inx 8207 40 decades decade NNS cord-010092-uftc8inx 8207 41 . . . cord-010092-uftc8inx 8208 1 Aims aim VBZ cord-010092-uftc8inx 8208 2 : : : cord-010092-uftc8inx 8209 1 Based base VBN cord-010092-uftc8inx 8209 2 on on IN cord-010092-uftc8inx 8209 3 laboratory laboratory NN cord-010092-uftc8inx 8209 4 markers marker NNS cord-010092-uftc8inx 8209 5 , , , cord-010092-uftc8inx 8209 6 active active JJ cord-010092-uftc8inx 8209 7 and and CC cord-010092-uftc8inx 8209 8 early early JJ cord-010092-uftc8inx 8209 9 Tp Tp NNP cord-010092-uftc8inx 8209 10 infected infected JJ cord-010092-uftc8inx 8209 11 donors donor NNS cord-010092-uftc8inx 8209 12 ( ( -LRB- cord-010092-uftc8inx 8209 13 AEID AEID NNP cord-010092-uftc8inx 8209 14 ) ) -RRB- cord-010092-uftc8inx 8209 15 were be VBD cord-010092-uftc8inx 8209 16 determined determine VBN cord-010092-uftc8inx 8209 17 . . . cord-010092-uftc8inx 8210 1 The the DT cord-010092-uftc8inx 8210 2 demographics demographic NNS cord-010092-uftc8inx 8210 3 of of IN cord-010092-uftc8inx 8210 4 AEID AEID NNP cord-010092-uftc8inx 8210 5 and and CC cord-010092-uftc8inx 8210 6 the the DT cord-010092-uftc8inx 8210 7 frequency frequency NN cord-010092-uftc8inx 8210 8 measures measure NNS cord-010092-uftc8inx 8210 9 of of IN cord-010092-uftc8inx 8210 10 cases case NNS cord-010092-uftc8inx 8210 11 were be VBD cord-010092-uftc8inx 8210 12 compared compare VBN cord-010092-uftc8inx 8210 13 with with IN cord-010092-uftc8inx 8210 14 that that DT cord-010092-uftc8inx 8210 15 of of IN cord-010092-uftc8inx 8210 16 early early JJ cord-010092-uftc8inx 8210 17 infected infected JJ cord-010092-uftc8inx 8210 18 syphilis syphili NNS cord-010092-uftc8inx 8210 19 cases case NNS cord-010092-uftc8inx 8210 20 ( ( -LRB- cord-010092-uftc8inx 8210 21 SYC SYC NNP cord-010092-uftc8inx 8210 22 ) ) -RRB- cord-010092-uftc8inx 8210 23 notified notify VBN cord-010092-uftc8inx 8210 24 from from IN cord-010092-uftc8inx 8210 25 the the DT cord-010092-uftc8inx 8210 26 18 18 CD cord-010092-uftc8inx 8210 27 to to IN cord-010092-uftc8inx 8210 28 65-year 65-year JJ cord-010092-uftc8inx 8210 29 - - HYPH cord-010092-uftc8inx 8210 30 old old JJ cord-010092-uftc8inx 8210 31 general general JJ cord-010092-uftc8inx 8210 32 population population NN cord-010092-uftc8inx 8210 33 registered register VBN cord-010092-uftc8inx 8210 34 at at IN cord-010092-uftc8inx 8210 35 the the DT cord-010092-uftc8inx 8210 36 NPHC NPHC NNP cord-010092-uftc8inx 8210 37 . . . cord-010092-uftc8inx 8211 1 Methods method NNS cord-010092-uftc8inx 8211 2 : : : cord-010092-uftc8inx 8212 1 Altogether altogether RB cord-010092-uftc8inx 8212 2 , , , cord-010092-uftc8inx 8212 3 474,017 474,017 CD cord-010092-uftc8inx 8212 4 18 18 CD cord-010092-uftc8inx 8212 5 to to IN cord-010092-uftc8inx 8212 6 65-year 65-year JJ cord-010092-uftc8inx 8212 7 - - HYPH cord-010092-uftc8inx 8212 8 old old JJ cord-010092-uftc8inx 8212 9 donors donor NNS cord-010092-uftc8inx 8212 10 were be VBD cord-010092-uftc8inx 8212 11 screened screen VBN cord-010092-uftc8inx 8212 12 with with IN cord-010092-uftc8inx 8212 13 anti anti JJ cord-010092-uftc8inx 8212 14 - - JJ cord-010092-uftc8inx 8212 15 Tp tp JJ cord-010092-uftc8inx 8212 16 immunoassay immunoassay NN cord-010092-uftc8inx 8212 17 ( ( -LRB- cord-010092-uftc8inx 8212 18 Architect Architect NNP cord-010092-uftc8inx 8212 19 Syphilis Syphilis NNP cord-010092-uftc8inx 8212 20 Tp Tp NNP cord-010092-uftc8inx 8212 21 , , , cord-010092-uftc8inx 8212 22 Abbott Abbott NNP cord-010092-uftc8inx 8212 23 , , , cord-010092-uftc8inx 8212 24 Wiesbaden Wiesbaden NNP cord-010092-uftc8inx 8212 25 , , , cord-010092-uftc8inx 8212 26 Germany Germany NNP cord-010092-uftc8inx 8212 27 ) ) -RRB- cord-010092-uftc8inx 8212 28 between between IN cord-010092-uftc8inx 8212 29 2015 2015 CD cord-010092-uftc8inx 8212 30 and and CC cord-010092-uftc8inx 8212 31 2017 2017 CD cord-010092-uftc8inx 8212 32 . . . cord-010092-uftc8inx 8213 1 Reactive reactive JJ cord-010092-uftc8inx 8213 2 results result NNS cord-010092-uftc8inx 8213 3 were be VBD cord-010092-uftc8inx 8213 4 confirmed confirm VBN cord-010092-uftc8inx 8213 5 with with IN cord-010092-uftc8inx 8213 6 immunoblots immunoblot NNS cord-010092-uftc8inx 8213 7 ( ( -LRB- cord-010092-uftc8inx 8213 8 Viramed Viramed NNP cord-010092-uftc8inx 8213 9 Biotech Biotech NNP cord-010092-uftc8inx 8213 10 AG AG NNP cord-010092-uftc8inx 8213 11 , , , cord-010092-uftc8inx 8213 12 Planegg Planegg NNP cord-010092-uftc8inx 8213 13 , , , cord-010092-uftc8inx 8213 14 Germany Germany NNP cord-010092-uftc8inx 8213 15 ) ) -RRB- cord-010092-uftc8inx 8213 16 , , , cord-010092-uftc8inx 8213 17 which which WDT cord-010092-uftc8inx 8213 18 discriminated discriminate VBD cord-010092-uftc8inx 8213 19 both both DT cord-010092-uftc8inx 8213 20 specific specific JJ cord-010092-uftc8inx 8213 21 anti anti JJ cord-010092-uftc8inx 8213 22 - - JJ cord-010092-uftc8inx 8213 23 Tp tp JJ cord-010092-uftc8inx 8213 24 ( ( -LRB- cord-010092-uftc8inx 8213 25 IgG IgG NNP cord-010092-uftc8inx 8213 26 , , , cord-010092-uftc8inx 8213 27 IgM IgM NNP cord-010092-uftc8inx 8213 28 ) ) -RRB- cord-010092-uftc8inx 8213 29 and and CC cord-010092-uftc8inx 8213 30 non non JJ cord-010092-uftc8inx 8213 31 - - JJ cord-010092-uftc8inx 8213 32 specific specific JJ cord-010092-uftc8inx 8213 33 VDRL VDRL NNP cord-010092-uftc8inx 8213 34 antibodies antibody NNS cord-010092-uftc8inx 8213 35 in in IN cord-010092-uftc8inx 8213 36 five five CD cord-010092-uftc8inx 8213 37 dilutions dilution NNS cord-010092-uftc8inx 8213 38 . . . cord-010092-uftc8inx 8214 1 Meeting meet VBG cord-010092-uftc8inx 8214 2 the the DT cord-010092-uftc8inx 8214 3 criteria criterion NNS cord-010092-uftc8inx 8214 4 of of IN cord-010092-uftc8inx 8214 5 anti anti JJ cord-010092-uftc8inx 8214 6 - - JJ cord-010092-uftc8inx 8214 7 Tp tp JJ cord-010092-uftc8inx 8214 8 IgG igg NN cord-010092-uftc8inx 8214 9 positivity positivity NN cord-010092-uftc8inx 8214 10 with with IN cord-010092-uftc8inx 8214 11 a a DT cord-010092-uftc8inx 8214 12 VDRL VDRL NNP cord-010092-uftc8inx 8214 13 titer titer NN cord-010092-uftc8inx 8214 14 of of IN cord-010092-uftc8inx 8214 15 ≥ ≥ CD cord-010092-uftc8inx 8214 16 1:8 1:8 CD cord-010092-uftc8inx 8214 17 and and CC cord-010092-uftc8inx 8214 18 anti anti JJ cord-010092-uftc8inx 8214 19 - - JJ cord-010092-uftc8inx 8214 20 Tp tp JJ cord-010092-uftc8inx 8214 21 IgM igm NN cord-010092-uftc8inx 8214 22 positivity positivity NN cord-010092-uftc8inx 8214 23 , , , cord-010092-uftc8inx 8214 24 donors donor NNS cord-010092-uftc8inx 8214 25 were be VBD cord-010092-uftc8inx 8214 26 considered consider VBN cord-010092-uftc8inx 8214 27 as as IN cord-010092-uftc8inx 8214 28 AEID AEID NNP cord-010092-uftc8inx 8214 29 . . . cord-010092-uftc8inx 8215 1 They -PRON- PRP cord-010092-uftc8inx 8215 2 were be VBD cord-010092-uftc8inx 8215 3 stratified stratify VBN cord-010092-uftc8inx 8215 4 by by IN cord-010092-uftc8inx 8215 5 age age NN cord-010092-uftc8inx 8215 6 , , , cord-010092-uftc8inx 8215 7 gender gender NN cord-010092-uftc8inx 8215 8 and and CC cord-010092-uftc8inx 8215 9 residence residence NN cord-010092-uftc8inx 8215 10 regions region NNS cord-010092-uftc8inx 8215 11 . . . cord-010092-uftc8inx 8216 1 The the DT cord-010092-uftc8inx 8216 2 proportion proportion NN cord-010092-uftc8inx 8216 3 of of IN cord-010092-uftc8inx 8216 4 AEID AEID NNP cord-010092-uftc8inx 8216 5 ( ( -LRB- cord-010092-uftc8inx 8216 6 PAEID PAEID NNP cord-010092-uftc8inx 8216 7 ) ) -RRB- cord-010092-uftc8inx 8216 8 and and CC cord-010092-uftc8inx 8216 9 SYC SYC NNP cord-010092-uftc8inx 8216 10 ( ( -LRB- cord-010092-uftc8inx 8216 11 PSYC PSYC NNP cord-010092-uftc8inx 8216 12 ) ) -RRB- cord-010092-uftc8inx 8216 13 were be VBD cord-010092-uftc8inx 8216 14 calculated calculate VBN cord-010092-uftc8inx 8216 15 in in IN cord-010092-uftc8inx 8216 16 first first JJ cord-010092-uftc8inx 8216 17 time time NN cord-010092-uftc8inx 8216 18 ( ( -LRB- cord-010092-uftc8inx 8216 19 FT FT NNP cord-010092-uftc8inx 8216 20 ) ) -RRB- cord-010092-uftc8inx 8216 21 , , , cord-010092-uftc8inx 8216 22 and and CC cord-010092-uftc8inx 8216 23 repeat repeat VB cord-010092-uftc8inx 8216 24 tested test VBN cord-010092-uftc8inx 8216 25 ( ( -LRB- cord-010092-uftc8inx 8216 26 RT RT NNP cord-010092-uftc8inx 8216 27 ) ) -RRB- cord-010092-uftc8inx 8216 28 donors donor NNS cord-010092-uftc8inx 8216 29 and and CC cord-010092-uftc8inx 8216 30 in in IN cord-010092-uftc8inx 8216 31 the the DT cord-010092-uftc8inx 8216 32 18 18 CD cord-010092-uftc8inx 8216 33 to to IN cord-010092-uftc8inx 8216 34 65-year 65-year JJ cord-010092-uftc8inx 8216 35 - - HYPH cord-010092-uftc8inx 8216 36 old old JJ cord-010092-uftc8inx 8216 37 general general JJ cord-010092-uftc8inx 8216 38 population population NN cord-010092-uftc8inx 8216 39 , , , cord-010092-uftc8inx 8216 40 respectively respectively RB cord-010092-uftc8inx 8216 41 , , , cord-010092-uftc8inx 8216 42 in in IN cord-010092-uftc8inx 8216 43 each each DT cord-010092-uftc8inx 8216 44 year year NN cord-010092-uftc8inx 8216 45 studied study VBD cord-010092-uftc8inx 8216 46 . . . cord-010092-uftc8inx 8217 1 The the DT cord-010092-uftc8inx 8217 2 period period NN cord-010092-uftc8inx 8217 3 prevalence prevalence NN cord-010092-uftc8inx 8217 4 ( ( -LRB- cord-010092-uftc8inx 8217 5 PP PP NNP cord-010092-uftc8inx 8217 6 ) ) -RRB- cord-010092-uftc8inx 8217 7 of of IN cord-010092-uftc8inx 8217 8 AEID AEID NNP cord-010092-uftc8inx 8217 9 and and CC cord-010092-uftc8inx 8217 10 SYC SYC NNP cord-010092-uftc8inx 8217 11 was be VBD cord-010092-uftc8inx 8217 12 estimated estimate VBN cord-010092-uftc8inx 8217 13 in in IN cord-010092-uftc8inx 8217 14 the the DT cord-010092-uftc8inx 8217 15 populations population NNS cord-010092-uftc8inx 8217 16 at at IN cord-010092-uftc8inx 8217 17 risk risk NN cord-010092-uftc8inx 8217 18 1,2 1,2 CD cord-010092-uftc8inx 8217 19 across across IN cord-010092-uftc8inx 8217 20 2015 2015 CD cord-010092-uftc8inx 8217 21 - - SYM cord-010092-uftc8inx 8217 22 2017 2017 CD cord-010092-uftc8inx 8217 23 . . . cord-010092-uftc8inx 8218 1 Statistics statistic NNS cord-010092-uftc8inx 8218 2 : : : cord-010092-uftc8inx 8218 3 weighted weighted JJ cord-010092-uftc8inx 8218 4 proportions proportion NNS cord-010092-uftc8inx 8218 5 and and CC cord-010092-uftc8inx 8218 6 one one CD cord-010092-uftc8inx 8218 7 - - HYPH cord-010092-uftc8inx 8218 8 way way NN cord-010092-uftc8inx 8218 9 ANOVA anova NN cord-010092-uftc8inx 8218 10 with with IN cord-010092-uftc8inx 8218 11 Tukey Tukey NNP cord-010092-uftc8inx 8218 12 Post Post NNP cord-010092-uftc8inx 8218 13 - - HYPH cord-010092-uftc8inx 8218 14 Hoc Hoc NNP cord-010092-uftc8inx 8218 15 test test NN cord-010092-uftc8inx 8218 16 and and CC cord-010092-uftc8inx 8218 17 z z NN cord-010092-uftc8inx 8218 18 score score NN cord-010092-uftc8inx 8218 19 test test NN cord-010092-uftc8inx 8218 20 were be VBD cord-010092-uftc8inx 8218 21 applied apply VBN cord-010092-uftc8inx 8218 22 . . . cord-010092-uftc8inx 8219 1 Statistical statistical JJ cord-010092-uftc8inx 8219 2 significance significance NN cord-010092-uftc8inx 8219 3 was be VBD cord-010092-uftc8inx 8219 4 defined define VBN cord-010092-uftc8inx 8219 5 as as IN cord-010092-uftc8inx 8219 6 P p NN cord-010092-uftc8inx 8219 7 < < XX cord-010092-uftc8inx 8219 8 0.05 0.05 CD cord-010092-uftc8inx 8219 9 . . . cord-010092-uftc8inx 8220 1 Results result NNS cord-010092-uftc8inx 8220 2 : : : cord-010092-uftc8inx 8221 1 Anti anti JJ cord-010092-uftc8inx 8221 2 - - JJ cord-010092-uftc8inx 8221 3 Tp tp JJ cord-010092-uftc8inx 8221 4 reactivity reactivity NN cord-010092-uftc8inx 8221 5 was be VBD cord-010092-uftc8inx 8221 6 confirmed confirm VBN cord-010092-uftc8inx 8221 7 in in IN cord-010092-uftc8inx 8221 8 167 167 CD cord-010092-uftc8inx 8221 9 blood blood NN cord-010092-uftc8inx 8221 10 donors donor NNS cord-010092-uftc8inx 8221 11 . . . cord-010092-uftc8inx 8222 1 AEID AEID NNP cord-010092-uftc8inx 8222 2 was be VBD cord-010092-uftc8inx 8222 3 proved prove VBN cord-010092-uftc8inx 8222 4 in in IN cord-010092-uftc8inx 8222 5 85 85 CD cord-010092-uftc8inx 8222 6 cases case NNS cord-010092-uftc8inx 8222 7 with with IN cord-010092-uftc8inx 8222 8 36 36 CD cord-010092-uftc8inx 8222 9 FT FT NNP cord-010092-uftc8inx 8222 10 and and CC cord-010092-uftc8inx 8222 11 49 49 CD cord-010092-uftc8inx 8222 12 RT RT NNP cord-010092-uftc8inx 8222 13 donors donor NNS cord-010092-uftc8inx 8222 14 . . . cord-010092-uftc8inx 8223 1 In in IN cord-010092-uftc8inx 8223 2 that that DT cord-010092-uftc8inx 8223 3 period period NN cord-010092-uftc8inx 8223 4 , , , cord-010092-uftc8inx 8223 5 1696 1696 CD cord-010092-uftc8inx 8223 6 SYC SYC NNP cord-010092-uftc8inx 8223 7 were be VBD cord-010092-uftc8inx 8223 8 notified notify VBN cord-010092-uftc8inx 8223 9 . . . cord-010092-uftc8inx 8224 1 Both both CC cord-010092-uftc8inx 8224 2 in in IN cord-010092-uftc8inx 8224 3 AEID AEID NNP cord-010092-uftc8inx 8224 4 and and CC cord-010092-uftc8inx 8224 5 SYC SYC NNP cord-010092-uftc8inx 8224 6 , , , cord-010092-uftc8inx 8224 7 the the DT cord-010092-uftc8inx 8224 8 age age NN cord-010092-uftc8inx 8224 9 group group NN cord-010092-uftc8inx 8224 10 of of IN cord-010092-uftc8inx 8224 11 25 25 CD cord-010092-uftc8inx 8224 12 - - SYM cord-010092-uftc8inx 8224 13 34 34 CD cord-010092-uftc8inx 8224 14 years year NNS cord-010092-uftc8inx 8224 15 with with IN cord-010092-uftc8inx 8224 16 approximately approximately RB cord-010092-uftc8inx 8224 17 35 35 CD cord-010092-uftc8inx 8224 18 % % NN cord-010092-uftc8inx 8224 19 and and CC cord-010092-uftc8inx 8224 20 36 36 CD cord-010092-uftc8inx 8224 21 % % NN cord-010092-uftc8inx 8224 22 of of IN cord-010092-uftc8inx 8224 23 individuals individual NNS cord-010092-uftc8inx 8224 24 was be VBD cord-010092-uftc8inx 8224 25 the the DT cord-010092-uftc8inx 8224 26 dominant dominant JJ cord-010092-uftc8inx 8224 27 . . . cord-010092-uftc8inx 8225 1 The the DT cord-010092-uftc8inx 8225 2 proportion proportion NN cord-010092-uftc8inx 8225 3 of of IN cord-010092-uftc8inx 8225 4 men man NNS cord-010092-uftc8inx 8225 5 was be VBD cord-010092-uftc8inx 8225 6 74 74 CD cord-010092-uftc8inx 8225 7 % % NN cord-010092-uftc8inx 8225 8 and and CC cord-010092-uftc8inx 8225 9 77 77 CD cord-010092-uftc8inx 8225 10 % % NN cord-010092-uftc8inx 8226 1 ( ( -LRB- cord-010092-uftc8inx 8226 2 P p NN cord-010092-uftc8inx 8226 3 = = SYM cord-010092-uftc8inx 8226 4 0.5 0.5 CD cord-010092-uftc8inx 8226 5 ) ) -RRB- cord-010092-uftc8inx 8226 6 in in IN cord-010092-uftc8inx 8226 7 the the DT cord-010092-uftc8inx 8226 8 AEID AEID NNP cord-010092-uftc8inx 8226 9 and and CC cord-010092-uftc8inx 8226 10 SYC SYC NNP cord-010092-uftc8inx 8226 11 , , , cord-010092-uftc8inx 8226 12 respectively respectively RB cord-010092-uftc8inx 8226 13 . . . cord-010092-uftc8inx 8227 1 PAEID PAEID NNP cord-010092-uftc8inx 8227 2 estimated estimate VBN cord-010092-uftc8inx 8227 3 in in IN cord-010092-uftc8inx 8227 4 FT FT NNP cord-010092-uftc8inx 8227 5 donors donor NNS cord-010092-uftc8inx 8227 6 was be VBD cord-010092-uftc8inx 8227 7 significantly significantly RB cord-010092-uftc8inx 8227 8 higher high JJR cord-010092-uftc8inx 8227 9 ( ( -LRB- cord-010092-uftc8inx 8227 10 0.020 0.020 CD cord-010092-uftc8inx 8227 11 % % NN cord-010092-uftc8inx 8227 12 ; ; : cord-010092-uftc8inx 8227 13 0.023 0.023 CD cord-010092-uftc8inx 8227 14 % % NN cord-010092-uftc8inx 8227 15 ; ; : cord-010092-uftc8inx 8227 16 0.032 0.032 CD cord-010092-uftc8inx 8227 17 % % NN cord-010092-uftc8inx 8227 18 , , , cord-010092-uftc8inx 8227 19 P p NN cord-010092-uftc8inx 8227 20 < < XX cord-010092-uftc8inx 8227 21 0.0001 0.0001 CD cord-010092-uftc8inx 8227 22 ) ) -RRB- cord-010092-uftc8inx 8227 23 than than IN cord-010092-uftc8inx 8227 24 that that DT cord-010092-uftc8inx 8227 25 of of IN cord-010092-uftc8inx 8227 26 RT RT NNP cord-010092-uftc8inx 8227 27 donors donor NNS cord-010092-uftc8inx 8227 28 ( ( -LRB- cord-010092-uftc8inx 8227 29 0.007 0.007 CD cord-010092-uftc8inx 8227 30 % % NN cord-010092-uftc8inx 8227 31 ; ; : cord-010092-uftc8inx 8227 32 0.009 0.009 CD cord-010092-uftc8inx 8227 33 % % NN cord-010092-uftc8inx 8227 34 ; ; : cord-010092-uftc8inx 8227 35 0.009 0.009 CD cord-010092-uftc8inx 8227 36 % % NN cord-010092-uftc8inx 8227 37 ) ) -RRB- cord-010092-uftc8inx 8227 38 and and CC cord-010092-uftc8inx 8227 39 the the DT cord-010092-uftc8inx 8227 40 proportion proportion NN cord-010092-uftc8inx 8227 41 of of IN cord-010092-uftc8inx 8227 42 SYC SYC NNP cord-010092-uftc8inx 8227 43 ( ( -LRB- cord-010092-uftc8inx 8227 44 0.008 0.008 CD cord-010092-uftc8inx 8227 45 % % NN cord-010092-uftc8inx 8227 46 ; ; : cord-010092-uftc8inx 8227 47 0.009 0.009 CD cord-010092-uftc8inx 8227 48 % % NN cord-010092-uftc8inx 8227 49 ; ; : cord-010092-uftc8inx 8227 50 0.010 0.010 CD cord-010092-uftc8inx 8227 51 % % NN cord-010092-uftc8inx 8227 52 ) ) -RRB- cord-010092-uftc8inx 8227 53 in in IN cord-010092-uftc8inx 8227 54 the the DT cord-010092-uftc8inx 8227 55 general general JJ cord-010092-uftc8inx 8227 56 population population NN cord-010092-uftc8inx 8227 57 . . . cord-010092-uftc8inx 8228 1 PP PP NNP cord-010092-uftc8inx 8228 2 of of IN cord-010092-uftc8inx 8228 3 AEID AEID NNP cord-010092-uftc8inx 8228 4 showed show VBD cord-010092-uftc8inx 8228 5 a a DT cord-010092-uftc8inx 8228 6 roughly roughly RB cord-010092-uftc8inx 8228 7 homogenous homogenous JJ cord-010092-uftc8inx 8228 8 distribution distribution NN cord-010092-uftc8inx 8228 9 in in IN cord-010092-uftc8inx 8228 10 the the DT cord-010092-uftc8inx 8228 11 7 7 CD cord-010092-uftc8inx 8228 12 regions region NNS cord-010092-uftc8inx 8228 13 ( ( -LRB- cord-010092-uftc8inx 8228 14 0.011%-0.025 0.011%-0.025 CD cord-010092-uftc8inx 8228 15 % % NN cord-010092-uftc8inx 8228 16 ) ) -RRB- cord-010092-uftc8inx 8228 17 , , , cord-010092-uftc8inx 8228 18 however however RB cord-010092-uftc8inx 8228 19 , , , cord-010092-uftc8inx 8228 20 PP PP NNP cord-010092-uftc8inx 8228 21 of of IN cord-010092-uftc8inx 8228 22 SYC SYC NNP cord-010092-uftc8inx 8228 23 had have VBD cord-010092-uftc8inx 8228 24 a a DT cord-010092-uftc8inx 8228 25 significant significant JJ cord-010092-uftc8inx 8228 26 ( ( -LRB- cord-010092-uftc8inx 8228 27 0.058 0.058 CD cord-010092-uftc8inx 8228 28 % % NN cord-010092-uftc8inx 8228 29 ; ; : cord-010092-uftc8inx 8228 30 P p NN cord-010092-uftc8inx 8228 31 < < XX cord-010092-uftc8inx 8228 32 0.0001 0.0001 CD cord-010092-uftc8inx 8228 33 ) ) -RRB- cord-010092-uftc8inx 8228 34 Central Central NNP cord-010092-uftc8inx 8228 35 Hungary Hungary NNP cord-010092-uftc8inx 8228 36 dominance dominance NN cord-010092-uftc8inx 8228 37 in in IN cord-010092-uftc8inx 8228 38 relation relation NN cord-010092-uftc8inx 8228 39 to to IN cord-010092-uftc8inx 8228 40 the the DT cord-010092-uftc8inx 8228 41 other other JJ cord-010092-uftc8inx 8228 42 regions region NNS cord-010092-uftc8inx 8228 43 ( ( -LRB- cord-010092-uftc8inx 8228 44 0.008%-0.016 0.008%-0.016 CD cord-010092-uftc8inx 8228 45 % % NN cord-010092-uftc8inx 8228 46 ) ) -RRB- cord-010092-uftc8inx 8228 47 . . . cord-010092-uftc8inx 8229 1 Comparing compare VBG cord-010092-uftc8inx 8229 2 the the DT cord-010092-uftc8inx 8229 3 PP PP NNP cord-010092-uftc8inx 8229 4 of of IN cord-010092-uftc8inx 8229 5 AEID AEID NNP cord-010092-uftc8inx 8229 6 to to IN cord-010092-uftc8inx 8229 7 SYC SYC NNP cord-010092-uftc8inx 8229 8 , , , cord-010092-uftc8inx 8229 9 Central Central NNP cord-010092-uftc8inx 8229 10 Hungary Hungary NNP cord-010092-uftc8inx 8229 11 indicated indicate VBD cord-010092-uftc8inx 8229 12 a a DT cord-010092-uftc8inx 8229 13 significant significant JJ cord-010092-uftc8inx 8229 14 difference difference NN cord-010092-uftc8inx 8229 15 ( ( -LRB- cord-010092-uftc8inx 8229 16 0.025 0.025 CD cord-010092-uftc8inx 8229 17 % % NN cord-010092-uftc8inx 8229 18 vs. vs. CC cord-010092-uftc8inx 8229 19 0.058 0.058 CD cord-010092-uftc8inx 8229 20 % % NN cord-010092-uftc8inx 8229 21 , , , cord-010092-uftc8inx 8229 22 P p NN cord-010092-uftc8inx 8229 23 < < XX cord-010092-uftc8inx 8229 24 0.0001 0.0001 CD cord-010092-uftc8inx 8229 25 ) ) -RRB- cord-010092-uftc8inx 8229 26 , , , cord-010092-uftc8inx 8229 27 however however RB cord-010092-uftc8inx 8229 28 , , , cord-010092-uftc8inx 8229 29 other other JJ cord-010092-uftc8inx 8229 30 regions region NNS cord-010092-uftc8inx 8229 31 showed show VBD cord-010092-uftc8inx 8229 32 no no DT cord-010092-uftc8inx 8229 33 substantial substantial JJ cord-010092-uftc8inx 8229 34 differences difference NNS cord-010092-uftc8inx 8229 35 . . . cord-010092-uftc8inx 8230 1 Summary Summary NNP cord-010092-uftc8inx 8230 2 / / SYM cord-010092-uftc8inx 8230 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 8230 4 : : : cord-010092-uftc8inx 8231 1 Donors donor NNS cord-010092-uftc8inx 8231 2 with with IN cord-010092-uftc8inx 8231 3 anti anti JJ cord-010092-uftc8inx 8231 4 - - NNP cord-010092-uftc8inx 8231 5 Tp Tp NNP cord-010092-uftc8inx 8231 6 confirmed confirm VBD cord-010092-uftc8inx 8231 7 positivity positivity NN cord-010092-uftc8inx 8231 8 are be VBP cord-010092-uftc8inx 8231 9 referred refer VBN cord-010092-uftc8inx 8231 10 to to IN cord-010092-uftc8inx 8231 11 the the DT cord-010092-uftc8inx 8231 12 healthcare healthcare NN cord-010092-uftc8inx 8231 13 system system NN cord-010092-uftc8inx 8231 14 . . . cord-010092-uftc8inx 8232 1 Based base VBN cord-010092-uftc8inx 8232 2 on on IN cord-010092-uftc8inx 8232 3 the the DT cord-010092-uftc8inx 8232 4 laboratory laboratory NN cord-010092-uftc8inx 8232 5 markers marker NNS cord-010092-uftc8inx 8232 6 tested test VBN cord-010092-uftc8inx 8232 7 , , , cord-010092-uftc8inx 8232 8 AEID AEID NNP cord-010092-uftc8inx 8232 9 could could MD cord-010092-uftc8inx 8232 10 be be VB cord-010092-uftc8inx 8232 11 separated separate VBN cord-010092-uftc8inx 8232 12 and and CC cord-010092-uftc8inx 8232 13 their -PRON- PRP$ cord-010092-uftc8inx 8232 14 demographical demographical JJ cord-010092-uftc8inx 8232 15 characteristics characteristic NNS cord-010092-uftc8inx 8232 16 are be VBP cord-010092-uftc8inx 8232 17 pretty pretty RB cord-010092-uftc8inx 8232 18 similar similar JJ cord-010092-uftc8inx 8232 19 to to IN cord-010092-uftc8inx 8232 20 that that DT cord-010092-uftc8inx 8232 21 of of IN cord-010092-uftc8inx 8232 22 SYC SYC NNP cord-010092-uftc8inx 8232 23 notified notify VBN cord-010092-uftc8inx 8232 24 from from IN cord-010092-uftc8inx 8232 25 the the DT cord-010092-uftc8inx 8232 26 general general JJ cord-010092-uftc8inx 8232 27 Hungarian hungarian JJ cord-010092-uftc8inx 8232 28 population population NN cord-010092-uftc8inx 8232 29 . . . cord-010092-uftc8inx 8233 1 The the DT cord-010092-uftc8inx 8233 2 proportion proportion NN cord-010092-uftc8inx 8233 3 of of IN cord-010092-uftc8inx 8233 4 early early JJ cord-010092-uftc8inx 8233 5 and and CC cord-010092-uftc8inx 8233 6 active active JJ cord-010092-uftc8inx 8233 7 infection infection NN cord-010092-uftc8inx 8233 8 in in IN cord-010092-uftc8inx 8233 9 FT FT NNP cord-010092-uftc8inx 8233 10 donors donor NNS cord-010092-uftc8inx 8233 11 is be VBZ cord-010092-uftc8inx 8233 12 significantly significantly RB cord-010092-uftc8inx 8233 13 higher high JJR cord-010092-uftc8inx 8233 14 than than IN cord-010092-uftc8inx 8233 15 that that DT cord-010092-uftc8inx 8233 16 of of IN cord-010092-uftc8inx 8233 17 RT RT NNP cord-010092-uftc8inx 8233 18 donors donor NNS cord-010092-uftc8inx 8233 19 and and CC cord-010092-uftc8inx 8233 20 the the DT cord-010092-uftc8inx 8233 21 proportion proportion NN cord-010092-uftc8inx 8233 22 of of IN cord-010092-uftc8inx 8233 23 SYC SYC NNP cord-010092-uftc8inx 8233 24 in in IN cord-010092-uftc8inx 8233 25 the the DT cord-010092-uftc8inx 8233 26 general general JJ cord-010092-uftc8inx 8233 27 population population NN cord-010092-uftc8inx 8233 28 . . . cord-010092-uftc8inx 8234 1 Given give VBN cord-010092-uftc8inx 8234 2 the the DT cord-010092-uftc8inx 8234 3 considerable considerable JJ cord-010092-uftc8inx 8234 4 number number NN cord-010092-uftc8inx 8234 5 of of IN cord-010092-uftc8inx 8234 6 Tp Tp NNP cord-010092-uftc8inx 8234 7 infection infection NN cord-010092-uftc8inx 8234 8 in in IN cord-010092-uftc8inx 8234 9 Background Background NNP cord-010092-uftc8inx 8234 10 : : : cord-010092-uftc8inx 8234 11 Quality quality NN cord-010092-uftc8inx 8234 12 assurance assurance NN cord-010092-uftc8inx 8234 13 and and CC cord-010092-uftc8inx 8234 14 safety safety NN cord-010092-uftc8inx 8234 15 of of IN cord-010092-uftc8inx 8234 16 hematopoietic hematopoietic JJ cord-010092-uftc8inx 8234 17 stem stem NN cord-010092-uftc8inx 8234 18 cells cell NNS cord-010092-uftc8inx 8234 19 ( ( -LRB- cord-010092-uftc8inx 8234 20 HSC HSC NNP cord-010092-uftc8inx 8234 21 ) ) -RRB- cord-010092-uftc8inx 8234 22 with with IN cord-010092-uftc8inx 8234 23 emphasis emphasis NN cord-010092-uftc8inx 8234 24 on on IN cord-010092-uftc8inx 8234 25 prevention prevention NN cord-010092-uftc8inx 8234 26 of of IN cord-010092-uftc8inx 8234 27 bacterial bacterial JJ cord-010092-uftc8inx 8234 28 and and CC cord-010092-uftc8inx 8234 29 fungal fungal JJ cord-010092-uftc8inx 8234 30 contamination contamination NN cord-010092-uftc8inx 8234 31 are be VBP cord-010092-uftc8inx 8234 32 the the DT cord-010092-uftc8inx 8234 33 prerequisites prerequisite NNS cord-010092-uftc8inx 8234 34 for for IN cord-010092-uftc8inx 8234 35 any any DT cord-010092-uftc8inx 8234 36 transplantation transplantation NN cord-010092-uftc8inx 8234 37 procedure procedure NN cord-010092-uftc8inx 8234 38 . . . cord-010092-uftc8inx 8235 1 Bacterial bacterial JJ cord-010092-uftc8inx 8235 2 contamination contamination NN cord-010092-uftc8inx 8235 3 is be VBZ cord-010092-uftc8inx 8235 4 of of IN cord-010092-uftc8inx 8235 5 particular particular JJ cord-010092-uftc8inx 8235 6 significance significance NN cord-010092-uftc8inx 8235 7 as as IN cord-010092-uftc8inx 8235 8 it -PRON- PRP cord-010092-uftc8inx 8235 9 occurs occur VBZ cord-010092-uftc8inx 8235 10 relatively relatively RB cord-010092-uftc8inx 8235 11 more more RBR cord-010092-uftc8inx 8235 12 frequently frequently RB cord-010092-uftc8inx 8235 13 and and CC cord-010092-uftc8inx 8235 14 bacteria bacteria NNS cord-010092-uftc8inx 8235 15 are be VBP cord-010092-uftc8inx 8235 16 gradually gradually RB cord-010092-uftc8inx 8235 17 gaining gain VBG cord-010092-uftc8inx 8235 18 more more JJR cord-010092-uftc8inx 8235 19 antimicrobial antimicrobial JJ cord-010092-uftc8inx 8235 20 resistance resistance NN cord-010092-uftc8inx 8235 21 . . . cord-010092-uftc8inx 8236 1 Aims aim VBZ cord-010092-uftc8inx 8236 2 : : : cord-010092-uftc8inx 8237 1 The the DT cord-010092-uftc8inx 8237 2 aim aim NN cord-010092-uftc8inx 8237 3 was be VBD cord-010092-uftc8inx 8237 4 to to TO cord-010092-uftc8inx 8237 5 determine determine VB cord-010092-uftc8inx 8237 6 the the DT cord-010092-uftc8inx 8237 7 incidence incidence NN cord-010092-uftc8inx 8237 8 rate rate NN cord-010092-uftc8inx 8237 9 of of IN cord-010092-uftc8inx 8237 10 bacterial bacterial JJ cord-010092-uftc8inx 8237 11 and and CC cord-010092-uftc8inx 8237 12 fungal fungal JJ cord-010092-uftc8inx 8237 13 contamination contamination NN cord-010092-uftc8inx 8237 14 during during IN cord-010092-uftc8inx 8237 15 processing processing NN cord-010092-uftc8inx 8237 16 of of IN cord-010092-uftc8inx 8237 17 transplantation transplantation NN cord-010092-uftc8inx 8237 18 material material NN cord-010092-uftc8inx 8237 19 at at IN cord-010092-uftc8inx 8237 20 the the DT cord-010092-uftc8inx 8237 21 Institute Institute NNP cord-010092-uftc8inx 8237 22 of of IN cord-010092-uftc8inx 8237 23 Hematology Hematology NNP cord-010092-uftc8inx 8237 24 and and CC cord-010092-uftc8inx 8237 25 Transfusion Transfusion NNP cord-010092-uftc8inx 8237 26 Medicine Medicine NNP cord-010092-uftc8inx 8237 27 ( ( -LRB- cord-010092-uftc8inx 8237 28 IHTM IHTM NNP cord-010092-uftc8inx 8237 29 ) ) -RRB- cord-010092-uftc8inx 8237 30 taking take VBG cord-010092-uftc8inx 8237 31 into into IN cord-010092-uftc8inx 8237 32 account account NN cord-010092-uftc8inx 8237 33 the the DT cord-010092-uftc8inx 8237 34 HSC HSC NNP cord-010092-uftc8inx 8237 35 sourceperipheral sourceperipheral JJ cord-010092-uftc8inx 8237 36 blood blood NN cord-010092-uftc8inx 8237 37 ( ( -LRB- cord-010092-uftc8inx 8237 38 PBSC PBSC NNP cord-010092-uftc8inx 8237 39 ) ) -RRB- cord-010092-uftc8inx 8237 40 , , , cord-010092-uftc8inx 8237 41 bone bone NN cord-010092-uftc8inx 8237 42 marrow marrow NN cord-010092-uftc8inx 8237 43 ( ( -LRB- cord-010092-uftc8inx 8237 44 BM BM NNP cord-010092-uftc8inx 8237 45 ) ) -RRB- cord-010092-uftc8inx 8237 46 or or CC cord-010092-uftc8inx 8237 47 cord cord NN cord-010092-uftc8inx 8237 48 blood blood NN cord-010092-uftc8inx 8237 49 ( ( -LRB- cord-010092-uftc8inx 8237 50 CB CB NNP cord-010092-uftc8inx 8237 51 ) ) -RRB- cord-010092-uftc8inx 8237 52 . . . cord-010092-uftc8inx 8238 1 Methods method NNS cord-010092-uftc8inx 8238 2 : : : cord-010092-uftc8inx 8238 3 Analysis analysis NN cord-010092-uftc8inx 8238 4 involved involve VBD cord-010092-uftc8inx 8238 5 both both CC cord-010092-uftc8inx 8238 6 autologous autologous JJ cord-010092-uftc8inx 8238 7 and and CC cord-010092-uftc8inx 8238 8 allogenic allogenic JJ cord-010092-uftc8inx 8238 9 components component NNS cord-010092-uftc8inx 8238 10 collected collect VBN cord-010092-uftc8inx 8238 11 at at IN cord-010092-uftc8inx 8238 12 IHTM IHTM NNP cord-010092-uftc8inx 8238 13 and and CC cord-010092-uftc8inx 8238 14 other other JJ cord-010092-uftc8inx 8238 15 hospitals hospital NNS cord-010092-uftc8inx 8238 16 and and CC cord-010092-uftc8inx 8238 17 dedicated dedicate VBN cord-010092-uftc8inx 8238 18 for for IN cord-010092-uftc8inx 8238 19 IHTM IHTM NNP cord-010092-uftc8inx 8238 20 patients patient NNS cord-010092-uftc8inx 8238 21 . . . cord-010092-uftc8inx 8239 1 In in IN cord-010092-uftc8inx 8239 2 all all DT cord-010092-uftc8inx 8239 3 , , , cord-010092-uftc8inx 8239 4 the the DT cord-010092-uftc8inx 8239 5 analysis analysis NN cord-010092-uftc8inx 8239 6 comprised comprise VBD cord-010092-uftc8inx 8239 7 4135 4135 CD cord-010092-uftc8inx 8239 8 donations donation NNS cord-010092-uftc8inx 8239 9 , , , cord-010092-uftc8inx 8239 10 including include VBG cord-010092-uftc8inx 8239 11 112 112 CD cord-010092-uftc8inx 8239 12 BM BM NNP cord-010092-uftc8inx 8239 13 ( ( -LRB- cord-010092-uftc8inx 8239 14 2.70 2.70 CD cord-010092-uftc8inx 8239 15 % % NN cord-010092-uftc8inx 8239 16 ) ) -RRB- cord-010092-uftc8inx 8239 17 , , , cord-010092-uftc8inx 8239 18 3787 3787 CD cord-010092-uftc8inx 8239 19 PBSC PBSC NNP cord-010092-uftc8inx 8239 20 ( ( -LRB- cord-010092-uftc8inx 8239 21 91.60 91.60 CD cord-010092-uftc8inx 8239 22 % % NN cord-010092-uftc8inx 8239 23 ) ) -RRB- cord-010092-uftc8inx 8239 24 and and CC cord-010092-uftc8inx 8239 25 236 236 CD cord-010092-uftc8inx 8239 26 CB CB NNP cord-010092-uftc8inx 8239 27 ( ( -LRB- cord-010092-uftc8inx 8239 28 5.70 5.70 CD cord-010092-uftc8inx 8239 29 % % NN cord-010092-uftc8inx 8239 30 ) ) -RRB- cord-010092-uftc8inx 8239 31 donations donation NNS cord-010092-uftc8inx 8239 32 processed process VBN cord-010092-uftc8inx 8239 33 in in IN cord-010092-uftc8inx 8239 34 our -PRON- PRP$ cord-010092-uftc8inx 8239 35 laboratory laboratory NN cord-010092-uftc8inx 8239 36 in in IN cord-010092-uftc8inx 8239 37 the the DT cord-010092-uftc8inx 8239 38 years year NNS cord-010092-uftc8inx 8239 39 1996 1996 CD cord-010092-uftc8inx 8239 40 - - SYM cord-010092-uftc8inx 8239 41 2016 2016 CD cord-010092-uftc8inx 8239 42 . . . cord-010092-uftc8inx 8240 1 BM BM NNP cord-010092-uftc8inx 8240 2 was be VBD cord-010092-uftc8inx 8240 3 collected collect VBN cord-010092-uftc8inx 8240 4 in in IN cord-010092-uftc8inx 8240 5 operating operate VBG cord-010092-uftc8inx 8240 6 theatre theatre NN cord-010092-uftc8inx 8240 7 - - HYPH cord-010092-uftc8inx 8240 8 conditions condition NNS cord-010092-uftc8inx 8240 9 , , , cord-010092-uftc8inx 8240 10 PBSC PBSC NNP cord-010092-uftc8inx 8240 11 with with IN cord-010092-uftc8inx 8240 12 cell cell NN cord-010092-uftc8inx 8240 13 separators separator NNS cord-010092-uftc8inx 8240 14 -CS-3000 -CS-3000 . cord-010092-uftc8inx 8240 15 ( ( -LRB- cord-010092-uftc8inx 8240 16 Baxter Baxter NNP cord-010092-uftc8inx 8240 17 ) ) -RRB- cord-010092-uftc8inx 8240 18 , , , cord-010092-uftc8inx 8240 19 Cobe Cobe NNP cord-010092-uftc8inx 8240 20 Spectra Spectra NNP cord-010092-uftc8inx 8240 21 ( ( -LRB- cord-010092-uftc8inx 8240 22 Gambro Gambro NNP cord-010092-uftc8inx 8240 23 ) ) -RRB- cord-010092-uftc8inx 8240 24 and and CC cord-010092-uftc8inx 8240 25 Trima Trima NNP cord-010092-uftc8inx 8240 26 Accel Accel NNP cord-010092-uftc8inx 8240 27 ( ( -LRB- cord-010092-uftc8inx 8240 28 Terumo Terumo NNP cord-010092-uftc8inx 8240 29 BCT BCT NNP cord-010092-uftc8inx 8240 30 ) ) -RRB- cord-010092-uftc8inx 8240 31 and and CC cord-010092-uftc8inx 8240 32 CB CB NNP cord-010092-uftc8inx 8240 33 was be VBD cord-010092-uftc8inx 8240 34 acquired acquire VBN cord-010092-uftc8inx 8240 35 from from IN cord-010092-uftc8inx 8240 36 umbilical umbilical JJ cord-010092-uftc8inx 8240 37 vein vein NN cord-010092-uftc8inx 8240 38 at at IN cord-010092-uftc8inx 8240 39 obstetrics obstetric NNS cord-010092-uftc8inx 8240 40 and and CC cord-010092-uftc8inx 8240 41 gynaecology gynaecology NN cord-010092-uftc8inx 8240 42 wards ward NNS cord-010092-uftc8inx 8240 43 . . . cord-010092-uftc8inx 8241 1 Aerobic aerobic JJ cord-010092-uftc8inx 8241 2 and and CC cord-010092-uftc8inx 8241 3 anaerobic anaerobic JJ cord-010092-uftc8inx 8241 4 bacteria bacteria NNS cord-010092-uftc8inx 8241 5 contamination contamination NN cord-010092-uftc8inx 8241 6 was be VBD cord-010092-uftc8inx 8241 7 determined determine VBN cord-010092-uftc8inx 8241 8 at at IN cord-010092-uftc8inx 8241 9 various various JJ cord-010092-uftc8inx 8241 10 incubation incubation NN cord-010092-uftc8inx 8241 11 temperatures temperature NNS cord-010092-uftc8inx 8241 12 ( ( -LRB- cord-010092-uftc8inx 8241 13 room room NN cord-010092-uftc8inx 8241 14 temperature temperature NN cord-010092-uftc8inx 8241 15 and and CC cord-010092-uftc8inx 8241 16 35 35 CD cord-010092-uftc8inx 8241 17 ° ° NN cord-010092-uftc8inx 8241 18 C c NN cord-010092-uftc8inx 8241 19 ) ) -RRB- cord-010092-uftc8inx 8241 20 using use VBG cord-010092-uftc8inx 8241 21 a a DT cord-010092-uftc8inx 8241 22 variety variety NN cord-010092-uftc8inx 8241 23 of of IN cord-010092-uftc8inx 8241 24 culture culture NN cord-010092-uftc8inx 8241 25 media medium NNS cord-010092-uftc8inx 8241 26 . . . cord-010092-uftc8inx 8242 1 PBSC PBSC NNP cord-010092-uftc8inx 8242 2 and and CC cord-010092-uftc8inx 8242 3 BM BM NNP cord-010092-uftc8inx 8242 4 were be VBD cord-010092-uftc8inx 8242 5 tested test VBN cord-010092-uftc8inx 8242 6 using use VBG cord-010092-uftc8inx 8242 7 2 2 CD cord-010092-uftc8inx 8242 8 samples sample NNS cord-010092-uftc8inx 8242 9 with with IN cord-010092-uftc8inx 8242 10 Trypcase Trypcase NNP cord-010092-uftc8inx 8242 11 - - HYPH cord-010092-uftc8inx 8242 12 soy soy NN cord-010092-uftc8inx 8242 13 broth broth NN cord-010092-uftc8inx 8242 14 ( ( -LRB- cord-010092-uftc8inx 8242 15 TSB TSB NNP cord-010092-uftc8inx 8242 16 - - HYPH cord-010092-uftc8inx 8242 17 T T NNP cord-010092-uftc8inx 8242 18 ) ) -RRB- cord-010092-uftc8inx 8242 19 and and CC cord-010092-uftc8inx 8242 20 1 1 CD cord-010092-uftc8inx 8242 21 with with IN cord-010092-uftc8inx 8242 22 Schaedler Schaedler NNP cord-010092-uftc8inx 8242 23 + + CC cord-010092-uftc8inx 8242 24 Vit Vit NNP cord-010092-uftc8inx 8242 25 K3 K3 NNP cord-010092-uftc8inx 8242 26 ( ( -LRB- cord-010092-uftc8inx 8242 27 BioMerieux BioMerieux NNP cord-010092-uftc8inx 8242 28 ) ) -RRB- cord-010092-uftc8inx 8242 29 . . . cord-010092-uftc8inx 8243 1 CB CB NNP cord-010092-uftc8inx 8243 2 was be VBD cord-010092-uftc8inx 8243 3 tested test VBN cord-010092-uftc8inx 8243 4 using use VBG cord-010092-uftc8inx 8243 5 Bactec Bactec NNP cord-010092-uftc8inx 8243 6 Peds Peds NNP cord-010092-uftc8inx 8243 7 Plus Plus NNP cord-010092-uftc8inx 8243 8 / / SYM cord-010092-uftc8inx 8243 9 F F NNP cord-010092-uftc8inx 8243 10 and and CC cord-010092-uftc8inx 8243 11 Bactec Bactec NNP cord-010092-uftc8inx 8243 12 Lytic/10 Lytic/10 NNP cord-010092-uftc8inx 8243 13 / / SYM cord-010092-uftc8inx 8243 14 Anaerobic Anaerobic NNP cord-010092-uftc8inx 8243 15 / / SYM cord-010092-uftc8inx 8243 16 F F NNP cord-010092-uftc8inx 8243 17 ( ( -LRB- cord-010092-uftc8inx 8243 18 Becton Becton NNP cord-010092-uftc8inx 8243 19 - - HYPH cord-010092-uftc8inx 8243 20 Dickinson Dickinson NNP cord-010092-uftc8inx 8243 21 ) ) -RRB- cord-010092-uftc8inx 8243 22 . . . cord-010092-uftc8inx 8244 1 Results result NNS cord-010092-uftc8inx 8244 2 : : : cord-010092-uftc8inx 8245 1 In in IN cord-010092-uftc8inx 8245 2 the the DT cord-010092-uftc8inx 8245 3 1996 1996 CD cord-010092-uftc8inx 8245 4 - - SYM cord-010092-uftc8inx 8245 5 2016 2016 CD cord-010092-uftc8inx 8245 6 period period NN cord-010092-uftc8inx 8245 7 42 42 CD cord-010092-uftc8inx 8245 8 contaminated contaminate VBN cord-010092-uftc8inx 8245 9 products product NNS cord-010092-uftc8inx 8245 10 were be VBD cord-010092-uftc8inx 8245 11 found find VBN cord-010092-uftc8inx 8245 12 : : : cord-010092-uftc8inx 8245 13 25 25 CD cord-010092-uftc8inx 8245 14 PBSC PBSC NNS cord-010092-uftc8inx 8245 15 ( ( -LRB- cord-010092-uftc8inx 8245 16 0.66 0.66 CD cord-010092-uftc8inx 8245 17 % % NN cord-010092-uftc8inx 8245 18 of of IN cord-010092-uftc8inx 8245 19 all all DT cord-010092-uftc8inx 8245 20 tested test VBN cord-010092-uftc8inx 8245 21 PBSC PBSC NNP cord-010092-uftc8inx 8245 22 units unit NNS cord-010092-uftc8inx 8245 23 ) ) -RRB- cord-010092-uftc8inx 8245 24 and and CC cord-010092-uftc8inx 8245 25 17 17 CD cord-010092-uftc8inx 8245 26 CB CB NNP cord-010092-uftc8inx 8245 27 ( ( -LRB- cord-010092-uftc8inx 8245 28 7.20 7.20 CD cord-010092-uftc8inx 8245 29 % % NN cord-010092-uftc8inx 8245 30 of of IN cord-010092-uftc8inx 8245 31 all all DT cord-010092-uftc8inx 8245 32 tested test VBN cord-010092-uftc8inx 8245 33 CB CB NNP cord-010092-uftc8inx 8245 34 units unit NNS cord-010092-uftc8inx 8245 35 ) ) -RRB- cord-010092-uftc8inx 8245 36 . . . cord-010092-uftc8inx 8246 1 No no DT cord-010092-uftc8inx 8246 2 infected infected JJ cord-010092-uftc8inx 8246 3 BM BM NNP cord-010092-uftc8inx 8246 4 products product NNS cord-010092-uftc8inx 8246 5 were be VBD cord-010092-uftc8inx 8246 6 determined determine VBN cord-010092-uftc8inx 8246 7 . . . cord-010092-uftc8inx 8247 1 The the DT cord-010092-uftc8inx 8247 2 overall overall JJ cord-010092-uftc8inx 8247 3 percentage percentage NN cord-010092-uftc8inx 8247 4 of of IN cord-010092-uftc8inx 8247 5 contaminated contaminate VBN cord-010092-uftc8inx 8247 6 products product NNS cord-010092-uftc8inx 8247 7 was be VBD cord-010092-uftc8inx 8247 8 estimated estimate VBN cord-010092-uftc8inx 8247 9 at at IN cord-010092-uftc8inx 8247 10 0,1 0,1 CD cord-010092-uftc8inx 8247 11 % % NN cord-010092-uftc8inx 8247 12 . . . cord-010092-uftc8inx 8248 1 In in IN cord-010092-uftc8inx 8248 2 2010 2010 CD cord-010092-uftc8inx 8248 3 , , , cord-010092-uftc8inx 8248 4 three three CD cord-010092-uftc8inx 8248 5 ( ( -LRB- cord-010092-uftc8inx 8248 6 3 3 CD cord-010092-uftc8inx 8248 7 ) ) -RRB- cord-010092-uftc8inx 8248 8 products product NNS cord-010092-uftc8inx 8248 9 were be VBD cord-010092-uftc8inx 8248 10 found find VBN cord-010092-uftc8inx 8248 11 contaminated contaminate VBN cord-010092-uftc8inx 8248 12 with with IN cord-010092-uftc8inx 8248 13 Staphylococcus Staphylococcus NNP cord-010092-uftc8inx 8248 14 epidermidis epidermidi NNS cord-010092-uftc8inx 8248 15 ; ; : cord-010092-uftc8inx 8248 16 all all DT cord-010092-uftc8inx 8248 17 came come VBD cord-010092-uftc8inx 8248 18 from from IN cord-010092-uftc8inx 8248 19 one one CD cord-010092-uftc8inx 8248 20 patient patient NN cord-010092-uftc8inx 8248 21 with with IN cord-010092-uftc8inx 8248 22 central central JJ cord-010092-uftc8inx 8248 23 venous venous JJ cord-010092-uftc8inx 8248 24 catheter catheter NN cord-010092-uftc8inx 8248 25 and and CC cord-010092-uftc8inx 8248 26 were be VBD cord-010092-uftc8inx 8248 27 collected collect VBN cord-010092-uftc8inx 8248 28 on on IN cord-010092-uftc8inx 8248 29 consecutive consecutive JJ cord-010092-uftc8inx 8248 30 days day NNS cord-010092-uftc8inx 8248 31 . . . cord-010092-uftc8inx 8249 1 Other other JJ cord-010092-uftc8inx 8249 2 products product NNS cord-010092-uftc8inx 8249 3 were be VBD cord-010092-uftc8inx 8249 4 contaminated contaminate VBN cord-010092-uftc8inx 8249 5 mostly mostly RB cord-010092-uftc8inx 8249 6 with with IN cord-010092-uftc8inx 8249 7 Staphylococcus Staphylococcus NNP cord-010092-uftc8inx 8249 8 epidermidis epidermidi NNS cord-010092-uftc8inx 8249 9 ( ( -LRB- cord-010092-uftc8inx 8249 10 61.36 61.36 CD cord-010092-uftc8inx 8249 11 % % NN cord-010092-uftc8inx 8249 12 ) ) -RRB- cord-010092-uftc8inx 8249 13 . . . cord-010092-uftc8inx 8250 1 Detailed detailed JJ cord-010092-uftc8inx 8250 2 results result NNS cord-010092-uftc8inx 8250 3 to to TO cord-010092-uftc8inx 8250 4 be be VB cord-010092-uftc8inx 8250 5 presented present VBN cord-010092-uftc8inx 8250 6 on on IN cord-010092-uftc8inx 8250 7 the the DT cord-010092-uftc8inx 8250 8 poster poster NN cord-010092-uftc8inx 8250 9 . . . cord-010092-uftc8inx 8251 1 Summary Summary NNP cord-010092-uftc8inx 8251 2 / / SYM cord-010092-uftc8inx 8251 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 8251 4 : : : cord-010092-uftc8inx 8252 1 According accord VBG cord-010092-uftc8inx 8252 2 to to IN cord-010092-uftc8inx 8252 3 IHTM IHTM NNP cord-010092-uftc8inx 8252 4 policy policy NN cord-010092-uftc8inx 8252 5 no no DT cord-010092-uftc8inx 8252 6 contaminated contaminate VBN cord-010092-uftc8inx 8252 7 product product NN cord-010092-uftc8inx 8252 8 is be VBZ cord-010092-uftc8inx 8252 9 admitted admit VBN cord-010092-uftc8inx 8252 10 to to IN cord-010092-uftc8inx 8252 11 clinical clinical JJ cord-010092-uftc8inx 8252 12 use use NN cord-010092-uftc8inx 8252 13 . . . cord-010092-uftc8inx 8253 1 The the DT cord-010092-uftc8inx 8253 2 outcome outcome NN cord-010092-uftc8inx 8253 3 of of IN cord-010092-uftc8inx 8253 4 our -PRON- PRP$ cord-010092-uftc8inx 8253 5 study study NN cord-010092-uftc8inx 8253 6 identifies identify VBZ cord-010092-uftc8inx 8253 7 processing processing NN cord-010092-uftc8inx 8253 8 experience experience NN cord-010092-uftc8inx 8253 9 of of IN cord-010092-uftc8inx 8253 10 the the DT cord-010092-uftc8inx 8253 11 staff staff NN cord-010092-uftc8inx 8253 12 as as IN cord-010092-uftc8inx 8253 13 the the DT cord-010092-uftc8inx 8253 14 main main JJ cord-010092-uftc8inx 8253 15 indicator indicator NN cord-010092-uftc8inx 8253 16 of of IN cord-010092-uftc8inx 8253 17 product product NN cord-010092-uftc8inx 8253 18 quality quality NN cord-010092-uftc8inx 8253 19 . . . cord-010092-uftc8inx 8254 1 Important important JJ cord-010092-uftc8inx 8254 2 is be VBZ cord-010092-uftc8inx 8254 3 also also RB cord-010092-uftc8inx 8254 4 proper proper JJ cord-010092-uftc8inx 8254 5 assessment assessment NN cord-010092-uftc8inx 8254 6 of of IN cord-010092-uftc8inx 8254 7 donor donor NN cord-010092-uftc8inx 8254 8 health health NN cord-010092-uftc8inx 8254 9 and and CC cord-010092-uftc8inx 8254 10 condition condition NN cord-010092-uftc8inx 8254 11 of of IN cord-010092-uftc8inx 8254 12 the the DT cord-010092-uftc8inx 8254 13 injection injection NN cord-010092-uftc8inx 8254 14 site site NN cord-010092-uftc8inx 8254 15 as as IN cord-010092-uftc8inx 8254 16 products product NNS cord-010092-uftc8inx 8254 17 are be VBP cord-010092-uftc8inx 8254 18 usually usually RB cord-010092-uftc8inx 8254 19 collected collect VBN cord-010092-uftc8inx 8254 20 from from IN cord-010092-uftc8inx 8254 21 central central JJ cord-010092-uftc8inx 8254 22 venous venous JJ cord-010092-uftc8inx 8254 23 catheter catheter NN cord-010092-uftc8inx 8254 24 . . . cord-010092-uftc8inx 8255 1 The the DT cord-010092-uftc8inx 8255 2 closed closed JJ cord-010092-uftc8inx 8255 3 system system NN cord-010092-uftc8inx 8255 4 is be VBZ cord-010092-uftc8inx 8255 5 an an DT cord-010092-uftc8inx 8255 6 additional additional JJ cord-010092-uftc8inx 8255 7 safeguard safeguard NN cord-010092-uftc8inx 8255 8 against against IN cord-010092-uftc8inx 8255 9 contamination contamination NN cord-010092-uftc8inx 8255 10 during during IN cord-010092-uftc8inx 8255 11 processing processing NN cord-010092-uftc8inx 8255 12 . . . cord-010092-uftc8inx 8256 1 The the DT cord-010092-uftc8inx 8256 2 sample sample NN cord-010092-uftc8inx 8256 3 collecting collecting NN cord-010092-uftc8inx 8256 4 procedure procedure NN cord-010092-uftc8inx 8256 5 should should MD cord-010092-uftc8inx 8256 6 help help VB cord-010092-uftc8inx 8256 7 to to TO cord-010092-uftc8inx 8256 8 avoid avoid VB cord-010092-uftc8inx 8256 9 false false JJ cord-010092-uftc8inx 8256 10 positive positive JJ cord-010092-uftc8inx 8256 11 results result NNS cord-010092-uftc8inx 8256 12 . . . cord-010092-uftc8inx 8257 1 Background background NN cord-010092-uftc8inx 8257 2 : : : cord-010092-uftc8inx 8258 1 Syphilis Syphilis NNP cord-010092-uftc8inx 8258 2 is be VBZ cord-010092-uftc8inx 8258 3 considered consider VBN cord-010092-uftc8inx 8258 4 a a DT cord-010092-uftc8inx 8258 5 global global JJ cord-010092-uftc8inx 8258 6 public public JJ cord-010092-uftc8inx 8258 7 health health NN cord-010092-uftc8inx 8258 8 problem problem NN cord-010092-uftc8inx 8258 9 . . . cord-010092-uftc8inx 8259 1 The the DT cord-010092-uftc8inx 8259 2 World World NNP cord-010092-uftc8inx 8259 3 Health Health NNP cord-010092-uftc8inx 8259 4 Organization Organization NNP cord-010092-uftc8inx 8259 5 ( ( -LRB- cord-010092-uftc8inx 8259 6 WHO who WP cord-010092-uftc8inx 8259 7 ) ) -RRB- cord-010092-uftc8inx 8259 8 estimates estimate VBZ cord-010092-uftc8inx 8259 9 that that IN cord-010092-uftc8inx 8259 10 there there EX cord-010092-uftc8inx 8259 11 are be VBP cord-010092-uftc8inx 8259 12 annually annually RB cord-010092-uftc8inx 8259 13 around around IN cord-010092-uftc8inx 8259 14 12 12 CD cord-010092-uftc8inx 8259 15 million million CD cord-010092-uftc8inx 8259 16 new new JJ cord-010092-uftc8inx 8259 17 cases case NNS cord-010092-uftc8inx 8259 18 of of IN cord-010092-uftc8inx 8259 19 syphilis syphili NNS cord-010092-uftc8inx 8259 20 in in IN cord-010092-uftc8inx 8259 21 the the DT cord-010092-uftc8inx 8259 22 world world NN cord-010092-uftc8inx 8259 23 , , , cord-010092-uftc8inx 8259 24 more more JJR cord-010092-uftc8inx 8259 25 than than IN cord-010092-uftc8inx 8259 26 90 90 CD cord-010092-uftc8inx 8259 27 % % NN cord-010092-uftc8inx 8259 28 occurring occur VBG cord-010092-uftc8inx 8259 29 in in IN cord-010092-uftc8inx 8259 30 developing develop VBG cord-010092-uftc8inx 8259 31 countries country NNS cord-010092-uftc8inx 8259 32 . . . cord-010092-uftc8inx 8260 1 Despite despite IN cord-010092-uftc8inx 8260 2 significant significant JJ cord-010092-uftc8inx 8260 3 decrease decrease NN cord-010092-uftc8inx 8260 4 in in IN cord-010092-uftc8inx 8260 5 syphilis syphili VBG cord-010092-uftc8inx 8260 6 transfusion transfusion NN cord-010092-uftc8inx 8260 7 transmission transmission NN cord-010092-uftc8inx 8260 8 . . . cord-010092-uftc8inx 8261 1 The the DT cord-010092-uftc8inx 8261 2 recent recent JJ cord-010092-uftc8inx 8261 3 increase increase NN cord-010092-uftc8inx 8261 4 in in IN cord-010092-uftc8inx 8261 5 worldwide worldwide JJ cord-010092-uftc8inx 8261 6 incidence incidence NN cord-010092-uftc8inx 8261 7 associated associate VBN cord-010092-uftc8inx 8261 8 with with IN cord-010092-uftc8inx 8261 9 the the DT cord-010092-uftc8inx 8261 10 risk risk NN cord-010092-uftc8inx 8261 11 of of IN cord-010092-uftc8inx 8261 12 transmission transmission NN cord-010092-uftc8inx 8261 13 through through IN cord-010092-uftc8inx 8261 14 platelet platelet NN cord-010092-uftc8inx 8261 15 concentrates concentrate NNS cord-010092-uftc8inx 8261 16 ( ( -LRB- cord-010092-uftc8inx 8261 17 CP CP NNP cord-010092-uftc8inx 8261 18 ) ) -RRB- cord-010092-uftc8inx 8261 19 , , , cord-010092-uftc8inx 8261 20 which which WDT cord-010092-uftc8inx 8261 21 are be VBP cord-010092-uftc8inx 8261 22 stored store VBN cord-010092-uftc8inx 8261 23 at at IN cord-010092-uftc8inx 8261 24 room room NN cord-010092-uftc8inx 8261 25 temperature temperature NN cord-010092-uftc8inx 8261 26 , , , cord-010092-uftc8inx 8261 27 have have VBP cord-010092-uftc8inx 8261 28 called call VBN cord-010092-uftc8inx 8261 29 attention attention NN cord-010092-uftc8inx 8261 30 to to IN cord-010092-uftc8inx 8261 31 the the DT cord-010092-uftc8inx 8261 32 potential potential JJ cord-010092-uftc8inx 8261 33 residual residual JJ cord-010092-uftc8inx 8261 34 risk risk NN cord-010092-uftc8inx 8261 35 of of IN cord-010092-uftc8inx 8261 36 syphilis syphili NNS cord-010092-uftc8inx 8261 37 transmission transmission NN cord-010092-uftc8inx 8261 38 by by IN cord-010092-uftc8inx 8261 39 transfusion transfusion NN cord-010092-uftc8inx 8261 40 . . . cord-010092-uftc8inx 8262 1 Between between IN cord-010092-uftc8inx 8262 2 2015 2015 CD cord-010092-uftc8inx 8262 3 and and CC cord-010092-uftc8inx 8262 4 2017 2017 CD cord-010092-uftc8inx 8262 5 we -PRON- PRP cord-010092-uftc8inx 8262 6 observed observe VBD cord-010092-uftc8inx 8262 7 in in IN cord-010092-uftc8inx 8262 8 our -PRON- PRP$ cord-010092-uftc8inx 8262 9 institution institution NN cord-010092-uftc8inx 8262 10 a a DT cord-010092-uftc8inx 8262 11 significant significant JJ cord-010092-uftc8inx 8262 12 increase increase NN cord-010092-uftc8inx 8262 13 of of IN cord-010092-uftc8inx 8262 14 24 24 CD cord-010092-uftc8inx 8262 15 % % NN cord-010092-uftc8inx 8262 16 in in IN cord-010092-uftc8inx 8262 17 positivity positivity NN cord-010092-uftc8inx 8262 18 of of IN cord-010092-uftc8inx 8262 19 syphilis syphili NNS cord-010092-uftc8inx 8262 20 among among IN cord-010092-uftc8inx 8262 21 blood blood NN cord-010092-uftc8inx 8262 22 donors donor NNS cord-010092-uftc8inx 8262 23 from from IN cord-010092-uftc8inx 8262 24 0.62 0.62 CD cord-010092-uftc8inx 8262 25 % % NN cord-010092-uftc8inx 8262 26 in in IN cord-010092-uftc8inx 8262 27 2015 2015 CD cord-010092-uftc8inx 8262 28 to to IN cord-010092-uftc8inx 8262 29 0.73 0.73 CD cord-010092-uftc8inx 8262 30 % % NN cord-010092-uftc8inx 8262 31 in in IN cord-010092-uftc8inx 8262 32 2016 2016 CD cord-010092-uftc8inx 8262 33 and and CC cord-010092-uftc8inx 8262 34 0.77 0.77 CD cord-010092-uftc8inx 8262 35 % % NN cord-010092-uftc8inx 8262 36 in in IN cord-010092-uftc8inx 8262 37 2017 2017 CD cord-010092-uftc8inx 8263 1 ( ( -LRB- cord-010092-uftc8inx 8263 2 P p NN cord-010092-uftc8inx 8263 3 < < XX cord-010092-uftc8inx 8263 4 0.0000001 0.0000001 CD cord-010092-uftc8inx 8263 5 ) ) -RRB- cord-010092-uftc8inx 8263 6 . . . cord-010092-uftc8inx 8264 1 Aims aim VBZ cord-010092-uftc8inx 8264 2 : : : cord-010092-uftc8inx 8264 3 To to TO cord-010092-uftc8inx 8264 4 determine determine VB cord-010092-uftc8inx 8264 5 the the DT cord-010092-uftc8inx 8264 6 prevalence prevalence NN cord-010092-uftc8inx 8264 7 of of IN cord-010092-uftc8inx 8264 8 active active JJ cord-010092-uftc8inx 8264 9 syphilis syphili NNS cord-010092-uftc8inx 8264 10 in in IN cord-010092-uftc8inx 8264 11 blood blood NN cord-010092-uftc8inx 8264 12 donors donor NNS cord-010092-uftc8inx 8264 13 and and CC cord-010092-uftc8inx 8264 14 characterize characterize VB cord-010092-uftc8inx 8264 15 the the DT cord-010092-uftc8inx 8264 16 serological serological JJ cord-010092-uftc8inx 8264 17 profile profile NN cord-010092-uftc8inx 8264 18 of of IN cord-010092-uftc8inx 8264 19 syphilis syphili VBG cord-010092-uftc8inx 8264 20 positive positive JJ cord-010092-uftc8inx 8264 21 donors donor NNS cord-010092-uftc8inx 8264 22 . . . cord-010092-uftc8inx 8265 1 Methods method NNS cord-010092-uftc8inx 8265 2 : : : cord-010092-uftc8inx 8266 1 Each each DT cord-010092-uftc8inx 8266 2 positive positive JJ cord-010092-uftc8inx 8266 3 sample sample NN cord-010092-uftc8inx 8266 4 in in IN cord-010092-uftc8inx 8266 5 a a DT cord-010092-uftc8inx 8266 6 treponemic treponemic JJ cord-010092-uftc8inx 8266 7 chemiluminescence chemiluminescence NN cord-010092-uftc8inx 8266 8 assay assay NN cord-010092-uftc8inx 8266 9 ( ( -LRB- cord-010092-uftc8inx 8266 10 CMIA CMIA NNP cord-010092-uftc8inx 8266 11 , , , cord-010092-uftc8inx 8266 12 Abbott Abbott NNP cord-010092-uftc8inx 8266 13 Architect Architect NNP cord-010092-uftc8inx 8266 14 ) ) -RRB- cord-010092-uftc8inx 8266 15 performed perform VBD cord-010092-uftc8inx 8266 16 during during IN cord-010092-uftc8inx 8266 17 blood blood NN cord-010092-uftc8inx 8266 18 donor donor NN cord-010092-uftc8inx 8266 19 screening screening NN cord-010092-uftc8inx 8266 20 in in IN cord-010092-uftc8inx 8266 21 2017 2017 CD cord-010092-uftc8inx 8266 22 was be VBD cord-010092-uftc8inx 8266 23 submitted submit VBN cord-010092-uftc8inx 8266 24 to to IN cord-010092-uftc8inx 8266 25 a a DT cord-010092-uftc8inx 8266 26 treponemic treponemic NN cord-010092-uftc8inx 8266 27 Elisa Elisa NNP cord-010092-uftc8inx 8266 28 Anti Anti NNP cord-010092-uftc8inx 8266 29 - - NNP cord-010092-uftc8inx 8266 30 Treponema Treponema NNP cord-010092-uftc8inx 8266 31 pallidum pallidum NN cord-010092-uftc8inx 8266 32 IgM igm NN cord-010092-uftc8inx 8266 33 ( ( -LRB- cord-010092-uftc8inx 8266 34 Euroimmun Euroimmun NNP cord-010092-uftc8inx 8266 35 ) ) -RRB- cord-010092-uftc8inx 8266 36 and and CC cord-010092-uftc8inx 8266 37 a a DT cord-010092-uftc8inx 8266 38 non non JJ cord-010092-uftc8inx 8266 39 - - JJ cord-010092-uftc8inx 8266 40 treponemic treponemic JJ cord-010092-uftc8inx 8266 41 test test NN cord-010092-uftc8inx 8266 42 ( ( -LRB- cord-010092-uftc8inx 8266 43 ANTIGEN antigen NN cord-010092-uftc8inx 8266 44 - - HYPH cord-010092-uftc8inx 8266 45 Omega omega NN cord-010092-uftc8inx 8266 46 Diagnostics Diagnostics NNPS cord-010092-uftc8inx 8266 47 ) ) -RRB- cord-010092-uftc8inx 8266 48 . . . cord-010092-uftc8inx 8267 1 Samples sample NNS cord-010092-uftc8inx 8267 2 with with IN cord-010092-uftc8inx 8267 3 positive positive JJ cord-010092-uftc8inx 8267 4 results result NNS cord-010092-uftc8inx 8267 5 for for IN cord-010092-uftc8inx 8267 6 one one CD cord-010092-uftc8inx 8267 7 or or CC cord-010092-uftc8inx 8267 8 two two CD cord-010092-uftc8inx 8267 9 of of IN cord-010092-uftc8inx 8267 10 these these DT cord-010092-uftc8inx 8267 11 tests test NNS cord-010092-uftc8inx 8267 12 ( ( -LRB- cord-010092-uftc8inx 8267 13 indicating indicate VBG cord-010092-uftc8inx 8267 14 recent recent JJ cord-010092-uftc8inx 8267 15 Syphilis syphili NNS cord-010092-uftc8inx 8267 16 ) ) -RRB- cord-010092-uftc8inx 8267 17 were be VBD cord-010092-uftc8inx 8267 18 submitted submit VBN cord-010092-uftc8inx 8267 19 to to IN cord-010092-uftc8inx 8267 20 a a DT cord-010092-uftc8inx 8267 21 Real real JJ cord-010092-uftc8inx 8267 22 - - HYPH cord-010092-uftc8inx 8267 23 time time NN cord-010092-uftc8inx 8267 24 PCR PCR NNP cord-010092-uftc8inx 8267 25 for for IN cord-010092-uftc8inx 8267 26 syphilis syphili NNS cord-010092-uftc8inx 8267 27 . . . cord-010092-uftc8inx 8268 1 The the DT cord-010092-uftc8inx 8268 2 INNO INNO NNP cord-010092-uftc8inx 8268 3 - - HYPH cord-010092-uftc8inx 8268 4 LIA LIA NNP cord-010092-uftc8inx 8268 5 Syphilis Syphilis NNP cord-010092-uftc8inx 8268 6 - - HYPH cord-010092-uftc8inx 8268 7 Fujirebio Fujirebio NNP cord-010092-uftc8inx 8268 8 Immunoblot Immunoblot NNP cord-010092-uftc8inx 8268 9 test test NN cord-010092-uftc8inx 8268 10 was be VBD cord-010092-uftc8inx 8268 11 also also RB cord-010092-uftc8inx 8268 12 performed perform VBN cord-010092-uftc8inx 8268 13 for for IN cord-010092-uftc8inx 8268 14 samples sample NNS cord-010092-uftc8inx 8268 15 that that WDT cord-010092-uftc8inx 8268 16 presented present VBD cord-010092-uftc8inx 8268 17 a a DT cord-010092-uftc8inx 8268 18 positive positive JJ cord-010092-uftc8inx 8268 19 result result NN cord-010092-uftc8inx 8268 20 for for IN cord-010092-uftc8inx 8268 21 Elisa Elisa NNP cord-010092-uftc8inx 8268 22 - - HYPH cord-010092-uftc8inx 8268 23 IgM IgM NNP cord-010092-uftc8inx 8268 24 alone alone RB cord-010092-uftc8inx 8268 25 . . . cord-010092-uftc8inx 8269 1 Financial financial JJ cord-010092-uftc8inx 8269 2 support support NN cord-010092-uftc8inx 8269 3 : : : cord-010092-uftc8inx 8269 4 FAPESP FAPESP NNP cord-010092-uftc8inx 8269 5 2017/23028 2017/23028 CD cord-010092-uftc8inx 8269 6 - - SYM cord-010092-uftc8inx 8269 7 9 9 CD cord-010092-uftc8inx 8269 8 . . . cord-010092-uftc8inx 8270 1 Results result NNS cord-010092-uftc8inx 8270 2 : : : cord-010092-uftc8inx 8271 1 Among among IN cord-010092-uftc8inx 8271 2 123,851 123,851 CD cord-010092-uftc8inx 8271 3 samples sample NNS cord-010092-uftc8inx 8271 4 screened screen VBN cord-010092-uftc8inx 8271 5 in in IN cord-010092-uftc8inx 8271 6 2017 2017 CD cord-010092-uftc8inx 8271 7 , , , cord-010092-uftc8inx 8271 8 958 958 CD cord-010092-uftc8inx 8271 9 ( ( -LRB- cord-010092-uftc8inx 8271 10 0.77 0.77 CD cord-010092-uftc8inx 8271 11 % % NN cord-010092-uftc8inx 8271 12 ) ) -RRB- cord-010092-uftc8inx 8271 13 presented present VBD cord-010092-uftc8inx 8271 14 a a DT cord-010092-uftc8inx 8271 15 positive positive JJ cord-010092-uftc8inx 8271 16 result result NN cord-010092-uftc8inx 8271 17 for for IN cord-010092-uftc8inx 8271 18 CMIA CMIA NNP cord-010092-uftc8inx 8272 1 -Syphilis -Syphilis NNP cord-010092-uftc8inx 8272 2 . . . cord-010092-uftc8inx 8273 1 Of of IN cord-010092-uftc8inx 8273 2 these these DT cord-010092-uftc8inx 8273 3 , , , cord-010092-uftc8inx 8273 4 626 626 CD cord-010092-uftc8inx 8273 5 ( ( -LRB- cord-010092-uftc8inx 8273 6 65.4 65.4 CD cord-010092-uftc8inx 8273 7 % % NN cord-010092-uftc8inx 8273 8 ) ) -RRB- cord-010092-uftc8inx 8273 9 were be VBD cord-010092-uftc8inx 8273 10 included include VBN cord-010092-uftc8inx 8273 11 in in IN cord-010092-uftc8inx 8273 12 the the DT cord-010092-uftc8inx 8273 13 study study NN cord-010092-uftc8inx 8273 14 . . . cord-010092-uftc8inx 8274 1 A a DT cord-010092-uftc8inx 8274 2 total total NN cord-010092-uftc8inx 8274 3 of of IN cord-010092-uftc8inx 8274 4 106 106 CD cord-010092-uftc8inx 8274 5 samples sample NNS cord-010092-uftc8inx 8274 6 ( ( -LRB- cord-010092-uftc8inx 8274 7 17 17 CD cord-010092-uftc8inx 8274 8 % % NN cord-010092-uftc8inx 8274 9 ) ) -RRB- cord-010092-uftc8inx 8274 10 showed show VBD cord-010092-uftc8inx 8274 11 VDRL+/IgM+ vdrl+/igm+ NN cord-010092-uftc8inx 8274 12 ; ; : cord-010092-uftc8inx 8274 13 96 96 CD cord-010092-uftc8inx 8274 14 ( ( -LRB- cord-010092-uftc8inx 8274 15 15 15 CD cord-010092-uftc8inx 8274 16 % % NN cord-010092-uftc8inx 8274 17 ) ) -RRB- cord-010092-uftc8inx 8275 1 VDRL+/IgMand vdrl+/igmand NN cord-010092-uftc8inx 8275 2 28 28 CD cord-010092-uftc8inx 8275 3 ( ( -LRB- cord-010092-uftc8inx 8275 4 4.5 4.5 CD cord-010092-uftc8inx 8275 5 % % NN cord-010092-uftc8inx 8275 6 ) ) -RRB- cord-010092-uftc8inx 8275 7 VDRL VDRL NNP cord-010092-uftc8inx 8275 8 -/Elisa -/elisa WDT cord-010092-uftc8inx 8275 9 IgM+ IgM+ NNP cord-010092-uftc8inx 8275 10 . . . cord-010092-uftc8inx 8276 1 The the DT cord-010092-uftc8inx 8276 2 INNO INNO NNP cord-010092-uftc8inx 8276 3 - - HYPH cord-010092-uftc8inx 8276 4 LIA LIA NNP cord-010092-uftc8inx 8276 5 Syphilis Syphilis NNP cord-010092-uftc8inx 8276 6 test test NN cord-010092-uftc8inx 8276 7 was be VBD cord-010092-uftc8inx 8276 8 performed perform VBN cord-010092-uftc8inx 8276 9 as as IN cord-010092-uftc8inx 8276 10 a a DT cord-010092-uftc8inx 8276 11 confirmatory confirmatory JJ cord-010092-uftc8inx 8276 12 test test NN cord-010092-uftc8inx 8276 13 in in IN cord-010092-uftc8inx 8276 14 28 28 CD cord-010092-uftc8inx 8276 15 ( ( -LRB- cord-010092-uftc8inx 8276 16 4.5 4.5 CD cord-010092-uftc8inx 8276 17 % % NN cord-010092-uftc8inx 8276 18 ) ) -RRB- cord-010092-uftc8inx 8276 19 samples sample NNS cord-010092-uftc8inx 8276 20 that that WDT cord-010092-uftc8inx 8276 21 presented present VBD cord-010092-uftc8inx 8276 22 positive positive JJ cord-010092-uftc8inx 8276 23 results result NNS cord-010092-uftc8inx 8276 24 for for IN cord-010092-uftc8inx 8276 25 Elisa Elisa NNP cord-010092-uftc8inx 8276 26 IgM IgM NNP cord-010092-uftc8inx 8276 27 and and CC cord-010092-uftc8inx 8276 28 VDRL VDRL NNP cord-010092-uftc8inx 8276 29 negative negative JJ cord-010092-uftc8inx 8276 30 with with IN cord-010092-uftc8inx 8276 31 21 21 CD cord-010092-uftc8inx 8276 32 ( ( -LRB- cord-010092-uftc8inx 8276 33 3.35 3.35 CD cord-010092-uftc8inx 8276 34 % % NN cord-010092-uftc8inx 8276 35 ) ) -RRB- cord-010092-uftc8inx 8276 36 positive positive JJ cord-010092-uftc8inx 8276 37 results result NNS cord-010092-uftc8inx 8276 38 , , , cord-010092-uftc8inx 8276 39 1 1 CD cord-010092-uftc8inx 8276 40 ( ( -LRB- cord-010092-uftc8inx 8276 41 0.15 0.15 CD cord-010092-uftc8inx 8276 42 % % NN cord-010092-uftc8inx 8276 43 ) ) -RRB- cord-010092-uftc8inx 8276 44 undetermined undetermined JJ cord-010092-uftc8inx 8276 45 and and CC cord-010092-uftc8inx 8276 46 6 6 CD cord-010092-uftc8inx 8276 47 ( ( -LRB- cord-010092-uftc8inx 8276 48 0.95 0.95 CD cord-010092-uftc8inx 8276 49 % % NN cord-010092-uftc8inx 8276 50 ) ) -RRB- cord-010092-uftc8inx 8276 51 negative negative JJ cord-010092-uftc8inx 8276 52 . . . cord-010092-uftc8inx 8277 1 None none NN cord-010092-uftc8inx 8277 2 of of IN cord-010092-uftc8inx 8277 3 the the DT cord-010092-uftc8inx 8277 4 626 626 CD cord-010092-uftc8inx 8277 5 samples sample NNS cord-010092-uftc8inx 8277 6 showed show VBD cord-010092-uftc8inx 8277 7 the the DT cord-010092-uftc8inx 8277 8 presence presence NN cord-010092-uftc8inx 8277 9 of of IN cord-010092-uftc8inx 8277 10 Treponema Treponema NNP cord-010092-uftc8inx 8277 11 DNA DNA NNP cord-010092-uftc8inx 8277 12 by by IN cord-010092-uftc8inx 8277 13 real real JJ cord-010092-uftc8inx 8277 14 - - HYPH cord-010092-uftc8inx 8277 15 time time NN cord-010092-uftc8inx 8277 16 PCR PCR NNP cord-010092-uftc8inx 8277 17 . . . cord-010092-uftc8inx 8278 1 The the DT cord-010092-uftc8inx 8278 2 prevalence prevalence NN cord-010092-uftc8inx 8278 3 was be VBD cord-010092-uftc8inx 8278 4 0.77 0.77 CD cord-010092-uftc8inx 8278 5 % % NN cord-010092-uftc8inx 8278 6 , , , cord-010092-uftc8inx 8278 7 the the DT cord-010092-uftc8inx 8278 8 incidence incidence NN cord-010092-uftc8inx 8278 9 was be VBD cord-010092-uftc8inx 8278 10 0.1 0.1 CD cord-010092-uftc8inx 8278 11 % % NN cord-010092-uftc8inx 8278 12 in in IN cord-010092-uftc8inx 8278 13 the the DT cord-010092-uftc8inx 8278 14 year year NN cord-010092-uftc8inx 8278 15 2017 2017 CD cord-010092-uftc8inx 8278 16 , , , cord-010092-uftc8inx 8278 17 and and CC cord-010092-uftc8inx 8278 18 the the DT cord-010092-uftc8inx 8278 19 incidence incidence NN cord-010092-uftc8inx 8278 20 in in IN cord-010092-uftc8inx 8278 21 relation relation NN cord-010092-uftc8inx 8278 22 to to IN cord-010092-uftc8inx 8278 23 the the DT cord-010092-uftc8inx 8278 24 total total JJ cord-010092-uftc8inx 8278 25 positivity positivity NN cord-010092-uftc8inx 8278 26 was be VBD cord-010092-uftc8inx 8278 27 20.4 20.4 CD cord-010092-uftc8inx 8278 28 % % NN cord-010092-uftc8inx 8278 29 . . . cord-010092-uftc8inx 8279 1 Both both DT cord-010092-uftc8inx 8279 2 , , , cord-010092-uftc8inx 8279 3 prevalence prevalence NN cord-010092-uftc8inx 8279 4 and and CC cord-010092-uftc8inx 8279 5 incidence incidence NN cord-010092-uftc8inx 8279 6 were be VBD cord-010092-uftc8inx 8279 7 higher high JJR cord-010092-uftc8inx 8279 8 in in IN cord-010092-uftc8inx 8279 9 men man NNS cord-010092-uftc8inx 8279 10 , , , cord-010092-uftc8inx 8279 11 white white JJ cord-010092-uftc8inx 8279 12 , , , cord-010092-uftc8inx 8279 13 not not RB cord-010092-uftc8inx 8279 14 married marry VBN cord-010092-uftc8inx 8279 15 , , , cord-010092-uftc8inx 8279 16 aging age VBG cord-010092-uftc8inx 8279 17 18 18 CD cord-010092-uftc8inx 8279 18 - - SYM cord-010092-uftc8inx 8279 19 29 29 CD cord-010092-uftc8inx 8279 20 years year NNS cord-010092-uftc8inx 8279 21 and and CC cord-010092-uftc8inx 8279 22 high high JJ cord-010092-uftc8inx 8279 23 school school NN cord-010092-uftc8inx 8279 24 educational educational JJ cord-010092-uftc8inx 8279 25 level level NN cord-010092-uftc8inx 8279 26 . . . cord-010092-uftc8inx 8280 1 We -PRON- PRP cord-010092-uftc8inx 8280 2 observed observe VBD cord-010092-uftc8inx 8280 3 a a DT cord-010092-uftc8inx 8280 4 6 6 CD cord-010092-uftc8inx 8280 5 % % NN cord-010092-uftc8inx 8280 6 a a DT cord-010092-uftc8inx 8280 7 - - HYPH cord-010092-uftc8inx 8280 8 HBc hbc JJ cord-010092-uftc8inx 8280 9 seroprevalence seroprevalence NN cord-010092-uftc8inx 8280 10 in in IN cord-010092-uftc8inx 8280 11 the the DT cord-010092-uftc8inx 8280 12 Elisa Elisa NNP cord-010092-uftc8inx 8280 13 IgM igm NN cord-010092-uftc8inx 8280 14 - - HYPH cord-010092-uftc8inx 8280 15 Syphilis syphili VBN cord-010092-uftc8inx 8280 16 positive positive JJ cord-010092-uftc8inx 8280 17 samples sample NNS cord-010092-uftc8inx 8280 18 and and CC cord-010092-uftc8inx 8280 19 a a DT cord-010092-uftc8inx 8280 20 prevalence prevalence NN cord-010092-uftc8inx 8280 21 of of IN cord-010092-uftc8inx 8280 22 1.5 1.5 CD cord-010092-uftc8inx 8280 23 % % NN cord-010092-uftc8inx 8280 24 HTLV HTLV NNP cord-010092-uftc8inx 8280 25 coinfection coinfection NN cord-010092-uftc8inx 8280 26 . . . cord-010092-uftc8inx 8281 1 Summary Summary NNP cord-010092-uftc8inx 8281 2 / / SYM cord-010092-uftc8inx 8281 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 8282 1 : : : cord-010092-uftc8inx 8282 2 We -PRON- PRP cord-010092-uftc8inx 8282 3 observed observe VBD cord-010092-uftc8inx 8282 4 a a DT cord-010092-uftc8inx 8282 5 significant significant JJ cord-010092-uftc8inx 8282 6 increase increase NN cord-010092-uftc8inx 8282 7 in in IN cord-010092-uftc8inx 8282 8 prevalence prevalence NN cord-010092-uftc8inx 8282 9 of of IN cord-010092-uftc8inx 8282 10 syphilis syphili NNS cord-010092-uftc8inx 8282 11 in in IN cord-010092-uftc8inx 8282 12 2017 2017 CD cord-010092-uftc8inx 8282 13 ( ( -LRB- cord-010092-uftc8inx 8282 14 0.77 0.77 CD cord-010092-uftc8inx 8282 15 % % NN cord-010092-uftc8inx 8282 16 ) ) -RRB- cord-010092-uftc8inx 8282 17 with with IN cord-010092-uftc8inx 8282 18 an an DT cord-010092-uftc8inx 8282 19 incidence incidence NN cord-010092-uftc8inx 8282 20 of of IN cord-010092-uftc8inx 8282 21 20.4 20.4 CD cord-010092-uftc8inx 8282 22 % % NN cord-010092-uftc8inx 8282 23 of of IN cord-010092-uftc8inx 8282 24 the the DT cord-010092-uftc8inx 8282 25 total total NN cord-010092-uftc8inx 8282 26 of of IN cord-010092-uftc8inx 8282 27 cases case NNS cord-010092-uftc8inx 8282 28 initially initially RB cord-010092-uftc8inx 8282 29 positive positive JJ cord-010092-uftc8inx 8282 30 in in IN cord-010092-uftc8inx 8282 31 the the DT cord-010092-uftc8inx 8282 32 CMIA CMIA NNP cord-010092-uftc8inx 8282 33 test test NN cord-010092-uftc8inx 8282 34 . . . cord-010092-uftc8inx 8283 1 According accord VBG cord-010092-uftc8inx 8283 2 to to IN cord-010092-uftc8inx 8283 3 our -PRON- PRP$ cord-010092-uftc8inx 8283 4 data datum NNS cord-010092-uftc8inx 8283 5 , , , cord-010092-uftc8inx 8283 6 we -PRON- PRP cord-010092-uftc8inx 8283 7 could could MD cord-010092-uftc8inx 8283 8 identify identify VB cord-010092-uftc8inx 8283 9 a a DT cord-010092-uftc8inx 8283 10 risk risk NN cord-010092-uftc8inx 8283 11 of of IN cord-010092-uftc8inx 8283 12 syphilis syphili VBN cord-010092-uftc8inx 8283 13 transfusion transfusion NN cord-010092-uftc8inx 8283 14 transmission transmission NN cord-010092-uftc8inx 8283 15 in in IN cord-010092-uftc8inx 8283 16 blood blood NN cord-010092-uftc8inx 8283 17 banks bank NNS cord-010092-uftc8inx 8283 18 that that WDT cord-010092-uftc8inx 8283 19 exclusively exclusively RB cord-010092-uftc8inx 8283 20 use use VBP cord-010092-uftc8inx 8283 21 the the DT cord-010092-uftc8inx 8283 22 VDRL VDRL NNP cord-010092-uftc8inx 8283 23 for for IN cord-010092-uftc8inx 8283 24 donor donor NN cord-010092-uftc8inx 8283 25 screening screening NN cord-010092-uftc8inx 8283 26 , , , cord-010092-uftc8inx 8283 27 once once IN cord-010092-uftc8inx 8283 28 we -PRON- PRP cord-010092-uftc8inx 8283 29 found find VBD cord-010092-uftc8inx 8283 30 22 22 CD cord-010092-uftc8inx 8283 31 ( ( -LRB- cord-010092-uftc8inx 8283 32 3.5 3.5 CD cord-010092-uftc8inx 8283 33 % % NN cord-010092-uftc8inx 8283 34 ) ) -RRB- cord-010092-uftc8inx 8283 35 cases case NNS cord-010092-uftc8inx 8283 36 with with IN cord-010092-uftc8inx 8283 37 negative negative JJ cord-010092-uftc8inx 8283 38 VDRL VDRL NNP cord-010092-uftc8inx 8283 39 and and CC cord-010092-uftc8inx 8283 40 Elisa Elisa NNP cord-010092-uftc8inx 8283 41 IgM IgM NNP cord-010092-uftc8inx 8283 42 and and CC cord-010092-uftc8inx 8284 1 INNO INNO NNP cord-010092-uftc8inx 8284 2 - - HYPH cord-010092-uftc8inx 8284 3 LIA LIA NNP cord-010092-uftc8inx 8284 4 positive positive JJ cord-010092-uftc8inx 8284 5 . . . cord-010092-uftc8inx 8285 1 Continuous continuous JJ cord-010092-uftc8inx 8285 2 monitoring monitoring NN cord-010092-uftc8inx 8285 3 of of IN cord-010092-uftc8inx 8285 4 the the DT cord-010092-uftc8inx 8285 5 profile profile NN cord-010092-uftc8inx 8285 6 of of IN cord-010092-uftc8inx 8285 7 donors donor NNS cord-010092-uftc8inx 8285 8 infected infect VBN cord-010092-uftc8inx 8285 9 with with IN cord-010092-uftc8inx 8285 10 syphilis syphili NNS cord-010092-uftc8inx 8285 11 at at IN cord-010092-uftc8inx 8285 12 this this DT cord-010092-uftc8inx 8285 13 time time NN cord-010092-uftc8inx 8285 14 of of IN cord-010092-uftc8inx 8285 15 reemergence reemergence NN cord-010092-uftc8inx 8285 16 of of IN cord-010092-uftc8inx 8285 17 the the DT cord-010092-uftc8inx 8285 18 disease disease NN cord-010092-uftc8inx 8285 19 is be VBZ cord-010092-uftc8inx 8285 20 useful useful JJ cord-010092-uftc8inx 8285 21 and and CC cord-010092-uftc8inx 8285 22 important important JJ cord-010092-uftc8inx 8285 23 not not RB cord-010092-uftc8inx 8285 24 just just RB cord-010092-uftc8inx 8285 25 for for IN cord-010092-uftc8inx 8285 26 blood blood NN cord-010092-uftc8inx 8285 27 banks bank NNS cord-010092-uftc8inx 8285 28 , , , cord-010092-uftc8inx 8285 29 as as IN cord-010092-uftc8inx 8285 30 it -PRON- PRP cord-010092-uftc8inx 8285 31 reflects reflect VBZ cord-010092-uftc8inx 8285 32 the the DT cord-010092-uftc8inx 8285 33 epidemiological epidemiological JJ cord-010092-uftc8inx 8285 34 situation situation NN cord-010092-uftc8inx 8285 35 of of IN cord-010092-uftc8inx 8285 36 disease disease NN cord-010092-uftc8inx 8285 37 in in IN cord-010092-uftc8inx 8285 38 community community NN cord-010092-uftc8inx 8285 39 , , , cord-010092-uftc8inx 8285 40 and and CC cord-010092-uftc8inx 8285 41 can can MD cord-010092-uftc8inx 8285 42 contribute contribute VB cord-010092-uftc8inx 8285 43 to to IN cord-010092-uftc8inx 8285 44 the the DT cord-010092-uftc8inx 8285 45 definition definition NN cord-010092-uftc8inx 8285 46 of of IN cord-010092-uftc8inx 8285 47 health health NN cord-010092-uftc8inx 8285 48 policies policy NNS cord-010092-uftc8inx 8285 49 . . . cord-010092-uftc8inx 8286 1 Background background NN cord-010092-uftc8inx 8286 2 : : : cord-010092-uftc8inx 8287 1 Transfusion transfusion NN cord-010092-uftc8inx 8287 2 related relate VBN cord-010092-uftc8inx 8287 3 sepsis sepsis NN cord-010092-uftc8inx 8287 4 is be VBZ cord-010092-uftc8inx 8287 5 a a DT cord-010092-uftc8inx 8287 6 serious serious JJ cord-010092-uftc8inx 8287 7 concern concern NN cord-010092-uftc8inx 8287 8 limiting limit VBG cord-010092-uftc8inx 8287 9 platelet platelet NN cord-010092-uftc8inx 8287 10 storage storage NN cord-010092-uftc8inx 8287 11 time time NN cord-010092-uftc8inx 8287 12 to to IN cord-010092-uftc8inx 8287 13 5 5 CD cord-010092-uftc8inx 8287 14 days day NNS cord-010092-uftc8inx 8287 15 at at IN cord-010092-uftc8inx 8287 16 room room NN cord-010092-uftc8inx 8287 17 temperature temperature NN cord-010092-uftc8inx 8287 18 . . . cord-010092-uftc8inx 8288 1 While while IN cord-010092-uftc8inx 8288 2 most most JJS cord-010092-uftc8inx 8288 3 units unit NNS cord-010092-uftc8inx 8288 4 are be VBP cord-010092-uftc8inx 8288 5 screened screen VBN cord-010092-uftc8inx 8288 6 for for IN cord-010092-uftc8inx 8288 7 bacterial bacterial JJ cord-010092-uftc8inx 8288 8 contamination contamination NN cord-010092-uftc8inx 8288 9 when when WRB cord-010092-uftc8inx 8288 10 collected collect VBN cord-010092-uftc8inx 8288 11 , , , cord-010092-uftc8inx 8288 12 bacterial bacterial JJ cord-010092-uftc8inx 8288 13 monitoring monitoring NN cord-010092-uftc8inx 8288 14 methods method NNS cord-010092-uftc8inx 8288 15 can can MD cord-010092-uftc8inx 8288 16 take take VB cord-010092-uftc8inx 8288 17 up up IN cord-010092-uftc8inx 8288 18 to to TO cord-010092-uftc8inx 8288 19 7 7 CD cord-010092-uftc8inx 8288 20 days day NNS cord-010092-uftc8inx 8288 21 to to TO cord-010092-uftc8inx 8288 22 detect detect VB cord-010092-uftc8inx 8288 23 contamination contamination NN cord-010092-uftc8inx 8288 24 . . . cord-010092-uftc8inx 8289 1 Thus thus RB cord-010092-uftc8inx 8289 2 , , , cord-010092-uftc8inx 8289 3 cold cold JJ cord-010092-uftc8inx 8289 4 storage storage NN cord-010092-uftc8inx 8289 5 of of IN cord-010092-uftc8inx 8289 6 platelets platelet NNS cord-010092-uftc8inx 8289 7 represents represent VBZ cord-010092-uftc8inx 8289 8 an an DT cord-010092-uftc8inx 8289 9 attractive attractive JJ cord-010092-uftc8inx 8289 10 alternative alternative NN cord-010092-uftc8inx 8289 11 for for IN cord-010092-uftc8inx 8289 12 improving improve VBG cord-010092-uftc8inx 8289 13 platelet platelet NN cord-010092-uftc8inx 8289 14 safety safety NN cord-010092-uftc8inx 8289 15 . . . cord-010092-uftc8inx 8290 1 In in IN cord-010092-uftc8inx 8290 2 this this DT cord-010092-uftc8inx 8290 3 study study NN cord-010092-uftc8inx 8290 4 , , , cord-010092-uftc8inx 8290 5 we -PRON- PRP cord-010092-uftc8inx 8290 6 assessed assess VBD cord-010092-uftc8inx 8290 7 bacterial bacterial JJ cord-010092-uftc8inx 8290 8 growth growth NN cord-010092-uftc8inx 8290 9 in in IN cord-010092-uftc8inx 8290 10 platelets platelet NNS cord-010092-uftc8inx 8290 11 stored store VBN cord-010092-uftc8inx 8290 12 either either CC cord-010092-uftc8inx 8290 13 at at IN cord-010092-uftc8inx 8290 14 room room NN cord-010092-uftc8inx 8290 15 - - HYPH cord-010092-uftc8inx 8290 16 temperature temperature NN cord-010092-uftc8inx 8290 17 ( ( -LRB- cord-010092-uftc8inx 8290 18 RT RT NNP cord-010092-uftc8inx 8290 19 ; ; : cord-010092-uftc8inx 8290 20 22 22 CD cord-010092-uftc8inx 8290 21 ° ° NN cord-010092-uftc8inx 8290 22 C C NNP cord-010092-uftc8inx 8290 23 ) ) -RRB- cord-010092-uftc8inx 8290 24 or or CC cord-010092-uftc8inx 8290 25 refrigerated refrigerate VBN cord-010092-uftc8inx 8290 26 ( ( -LRB- cord-010092-uftc8inx 8290 27 CS cs NN cord-010092-uftc8inx 8290 28 ; ; : cord-010092-uftc8inx 8290 29 4 4 CD cord-010092-uftc8inx 8290 30 ° ° NN cord-010092-uftc8inx 8290 31 C C NNP cord-010092-uftc8inx 8290 32 ) ) -RRB- cord-010092-uftc8inx 8290 33 . . . cord-010092-uftc8inx 8291 1 Aims aim VBZ cord-010092-uftc8inx 8291 2 : : : cord-010092-uftc8inx 8292 1 The the DT cord-010092-uftc8inx 8292 2 aims aim NNS cord-010092-uftc8inx 8292 3 of of IN cord-010092-uftc8inx 8292 4 this this DT cord-010092-uftc8inx 8292 5 study study NN cord-010092-uftc8inx 8292 6 were be VBD cord-010092-uftc8inx 8292 7 to to IN cord-010092-uftc8inx 8292 8 1 1 CD cord-010092-uftc8inx 8292 9 ) ) -RRB- cord-010092-uftc8inx 8292 10 assess assess VB cord-010092-uftc8inx 8292 11 the the DT cord-010092-uftc8inx 8292 12 effect effect NN cord-010092-uftc8inx 8292 13 of of IN cord-010092-uftc8inx 8292 14 storage storage NN cord-010092-uftc8inx 8292 15 temperature temperature NN cord-010092-uftc8inx 8292 16 on on IN cord-010092-uftc8inx 8292 17 platelet platelet NN cord-010092-uftc8inx 8292 18 function function NN cord-010092-uftc8inx 8292 19 and and CC cord-010092-uftc8inx 8292 20 bacterial bacterial JJ cord-010092-uftc8inx 8292 21 growth growth NN cord-010092-uftc8inx 8292 22 in in IN cord-010092-uftc8inx 8292 23 " " `` cord-010092-uftc8inx 8292 24 contaminated contaminated JJ cord-010092-uftc8inx 8292 25 " " '' cord-010092-uftc8inx 8292 26 platelet platelet NN cord-010092-uftc8inx 8292 27 units unit NNS cord-010092-uftc8inx 8292 28 , , , cord-010092-uftc8inx 8292 29 and and CC cord-010092-uftc8inx 8292 30 2 2 LS cord-010092-uftc8inx 8292 31 ) ) -RRB- cord-010092-uftc8inx 8292 32 identify identify VBP cord-010092-uftc8inx 8292 33 factors factor NNS cord-010092-uftc8inx 8292 34 contributing contribute VBG cord-010092-uftc8inx 8292 35 to to IN cord-010092-uftc8inx 8292 36 bacterial bacterial JJ cord-010092-uftc8inx 8292 37 growth growth NN cord-010092-uftc8inx 8292 38 during during IN cord-010092-uftc8inx 8292 39 RT RT NNP cord-010092-uftc8inx 8292 40 storage storage NN cord-010092-uftc8inx 8292 41 . . . cord-010092-uftc8inx 8293 1 Methods method NNS cord-010092-uftc8inx 8293 2 : : : cord-010092-uftc8inx 8293 3 Apheresis Apheresis NNP cord-010092-uftc8inx 8293 4 platelets platelet NNS cord-010092-uftc8inx 8293 5 in in IN cord-010092-uftc8inx 8293 6 plasma plasma NN cord-010092-uftc8inx 8293 7 ( ( -LRB- cord-010092-uftc8inx 8293 8 PLT PLT NNP cord-010092-uftc8inx 8293 9 ) ) -RRB- cord-010092-uftc8inx 8293 10 were be VBD cord-010092-uftc8inx 8293 11 obtained obtain VBN cord-010092-uftc8inx 8293 12 from from IN cord-010092-uftc8inx 8293 13 healthy healthy JJ cord-010092-uftc8inx 8293 14 donors donor NNS cord-010092-uftc8inx 8293 15 using use VBG cord-010092-uftc8inx 8293 16 the the DT cord-010092-uftc8inx 8293 17 Terumo Terumo NNP cord-010092-uftc8inx 8293 18 Trima Trima NNP cord-010092-uftc8inx 8293 19 Accel Accel NNP cord-010092-uftc8inx 8293 20 Automated Automated NNP cord-010092-uftc8inx 8293 21 Blood Blood NNP cord-010092-uftc8inx 8293 22 Collection Collection NNP cord-010092-uftc8inx 8293 23 System System NNP cord-010092-uftc8inx 8293 24 ( ( -LRB- cord-010092-uftc8inx 8293 25 Terumo Terumo NNP cord-010092-uftc8inx 8293 26 BCT BCT NNP cord-010092-uftc8inx 8293 27 ) ) -RRB- cord-010092-uftc8inx 8293 28 . . . cord-010092-uftc8inx 8294 1 Fresh fresh JJ cord-010092-uftc8inx 8294 2 plasma plasma NN cord-010092-uftc8inx 8294 3 ( ( -LRB- cord-010092-uftc8inx 8294 4 FP FP NNP cord-010092-uftc8inx 8294 5 ) ) -RRB- cord-010092-uftc8inx 8294 6 was be VBD cord-010092-uftc8inx 8294 7 collected collect VBN cord-010092-uftc8inx 8294 8 similarly similarly RB cord-010092-uftc8inx 8294 9 . . . cord-010092-uftc8inx 8295 1 Aliquots Aliquots NNP cord-010092-uftc8inx 8295 2 of of IN cord-010092-uftc8inx 8295 3 PLT PLT NNP cord-010092-uftc8inx 8295 4 or or CC cord-010092-uftc8inx 8295 5 FP FP NNP cord-010092-uftc8inx 8295 6 were be VBD cord-010092-uftc8inx 8295 7 transferred transfer VBN cord-010092-uftc8inx 8295 8 to to IN cord-010092-uftc8inx 8295 9 pH pH NNP cord-010092-uftc8inx 8295 10 SAFE SAFE NNP cord-010092-uftc8inx 8295 11 minibags minibag NNS cord-010092-uftc8inx 8295 12 ( ( -LRB- cord-010092-uftc8inx 8295 13 Blood blood NN cord-010092-uftc8inx 8295 14 Cell Cell NNP cord-010092-uftc8inx 8295 15 Storage Storage NNP cord-010092-uftc8inx 8295 16 , , , cord-010092-uftc8inx 8295 17 Inc Inc NNP cord-010092-uftc8inx 8295 18 ) ) -RRB- cord-010092-uftc8inx 8295 19 and and CC cord-010092-uftc8inx 8295 20 " " `` cord-010092-uftc8inx 8295 21 contaminated contaminate VBN cord-010092-uftc8inx 8295 22 " " '' cord-010092-uftc8inx 8295 23 with with IN cord-010092-uftc8inx 8295 24 Acinetobacter Acinetobacter NNP cord-010092-uftc8inx 8295 25 baumannii baumannii NNP cord-010092-uftc8inx 8295 26 , , , cord-010092-uftc8inx 8295 27 Escherichia Escherichia NNP cord-010092-uftc8inx 8295 28 coli coli NNS cord-010092-uftc8inx 8295 29 , , , cord-010092-uftc8inx 8295 30 Pseudomonas Pseudomonas NNP cord-010092-uftc8inx 8295 31 aeruginosa aeruginosa NN cord-010092-uftc8inx 8295 32 , , , cord-010092-uftc8inx 8295 33 Staphylococcus Staphylococcus NNP cord-010092-uftc8inx 8295 34 aureus aureus NN cord-010092-uftc8inx 8295 35 , , , cord-010092-uftc8inx 8295 36 Staphylococcus Staphylococcus NNP cord-010092-uftc8inx 8295 37 epidermidis epidermidi NNS cord-010092-uftc8inx 8295 38 , , , cord-010092-uftc8inx 8295 39 or or CC cord-010092-uftc8inx 8295 40 PBS PBS NNP cord-010092-uftc8inx 8295 41 ( ( -LRB- cord-010092-uftc8inx 8295 42 uninfected uninfected JJ cord-010092-uftc8inx 8295 43 control control NN cord-010092-uftc8inx 8295 44 ) ) -RRB- cord-010092-uftc8inx 8295 45 . . . cord-010092-uftc8inx 8296 1 Minibags Minibags NNP cord-010092-uftc8inx 8296 2 stored store VBN cord-010092-uftc8inx 8296 3 at at IN cord-010092-uftc8inx 8296 4 RT RT NNP cord-010092-uftc8inx 8296 5 were be VBD cord-010092-uftc8inx 8296 6 agitated agitate VBN cord-010092-uftc8inx 8296 7 using use VBG cord-010092-uftc8inx 8296 8 an an DT cord-010092-uftc8inx 8296 9 orbital orbital JJ cord-010092-uftc8inx 8296 10 shaker shaker NN cord-010092-uftc8inx 8296 11 set set VBN cord-010092-uftc8inx 8296 12 to to IN cord-010092-uftc8inx 8296 13 60 60 CD cord-010092-uftc8inx 8296 14 rpm rpm NN cord-010092-uftc8inx 8296 15 while while IN cord-010092-uftc8inx 8296 16 CS CS NNP cord-010092-uftc8inx 8296 17 aliquots aliquot NNS cord-010092-uftc8inx 8296 18 were be VBD cord-010092-uftc8inx 8296 19 stored store VBN cord-010092-uftc8inx 8296 20 under under IN cord-010092-uftc8inx 8296 21 static static JJ cord-010092-uftc8inx 8296 22 conditions condition NNS cord-010092-uftc8inx 8296 23 . . . cord-010092-uftc8inx 8297 1 Bacterial bacterial JJ cord-010092-uftc8inx 8297 2 growth growth NN cord-010092-uftc8inx 8297 3 was be VBD cord-010092-uftc8inx 8297 4 monitored monitor VBN cord-010092-uftc8inx 8297 5 daily daily RB cord-010092-uftc8inx 8297 6 through through IN cord-010092-uftc8inx 8297 7 dilution dilution NN cord-010092-uftc8inx 8297 8 plating plating NN cord-010092-uftc8inx 8297 9 . . . cord-010092-uftc8inx 8298 1 Lactate lactate NN cord-010092-uftc8inx 8298 2 levels level NNS cord-010092-uftc8inx 8298 3 were be VBD cord-010092-uftc8inx 8298 4 assessed assess VBN cord-010092-uftc8inx 8298 5 by by IN cord-010092-uftc8inx 8298 6 iSTAT istat NN cord-010092-uftc8inx 8298 7 ( ( -LRB- cord-010092-uftc8inx 8298 8 Abbott Abbott NNP cord-010092-uftc8inx 8298 9 ) ) -RRB- cord-010092-uftc8inx 8298 10 CG4 CG4 NNP cord-010092-uftc8inx 8298 11 + + CC cord-010092-uftc8inx 8298 12 test test NN cord-010092-uftc8inx 8298 13 cartridges cartridge NNS cord-010092-uftc8inx 8298 14 . . . cord-010092-uftc8inx 8299 1 Plasma plasma NN cord-010092-uftc8inx 8299 2 glucose glucose NN cord-010092-uftc8inx 8299 3 levels level NNS cord-010092-uftc8inx 8299 4 were be VBD cord-010092-uftc8inx 8299 5 assessed assess VBN cord-010092-uftc8inx 8299 6 using use VBG cord-010092-uftc8inx 8299 7 blood blood NN cord-010092-uftc8inx 8299 8 glucose glucose NN cord-010092-uftc8inx 8299 9 testing testing NN cord-010092-uftc8inx 8299 10 strips strip NNS cord-010092-uftc8inx 8299 11 ( ( -LRB- cord-010092-uftc8inx 8299 12 Germaine Germaine NNP cord-010092-uftc8inx 8299 13 Laboratories Laboratories NNPS cord-010092-uftc8inx 8299 14 ) ) -RRB- cord-010092-uftc8inx 8299 15 . . . cord-010092-uftc8inx 8300 1 Platelet platelet NN cord-010092-uftc8inx 8300 2 activation activation NN cord-010092-uftc8inx 8300 3 and and CC cord-010092-uftc8inx 8300 4 aggregation aggregation NN cord-010092-uftc8inx 8300 5 were be VBD cord-010092-uftc8inx 8300 6 assessed assess VBN cord-010092-uftc8inx 8300 7 on on IN cord-010092-uftc8inx 8300 8 days day NNS cord-010092-uftc8inx 8300 9 0 0 CD cord-010092-uftc8inx 8300 10 , , , cord-010092-uftc8inx 8300 11 1 1 CD cord-010092-uftc8inx 8300 12 , , , cord-010092-uftc8inx 8300 13 3 3 CD cord-010092-uftc8inx 8300 14 , , , cord-010092-uftc8inx 8300 15 and and CC cord-010092-uftc8inx 8300 16 5 5 CD cord-010092-uftc8inx 8300 17 by by IN cord-010092-uftc8inx 8300 18 flow flow NN cord-010092-uftc8inx 8300 19 cytometry cytometry NN cord-010092-uftc8inx 8300 20 and and CC cord-010092-uftc8inx 8300 21 Multiplate Multiplate NNP cord-010092-uftc8inx 8300 22 platelet platelet NN cord-010092-uftc8inx 8300 23 aggregometry aggregometry NN cord-010092-uftc8inx 8300 24 , , , cord-010092-uftc8inx 8300 25 respectively respectively RB cord-010092-uftc8inx 8300 26 . . . cord-010092-uftc8inx 8301 1 Results result NNS cord-010092-uftc8inx 8301 2 : : : cord-010092-uftc8inx 8301 3 Bacterial bacterial JJ cord-010092-uftc8inx 8301 4 growth growth NN cord-010092-uftc8inx 8301 5 progressed progress VBD cord-010092-uftc8inx 8301 6 rapidly rapidly RB cord-010092-uftc8inx 8301 7 over over IN cord-010092-uftc8inx 8301 8 the the DT cord-010092-uftc8inx 8301 9 first first JJ cord-010092-uftc8inx 8301 10 3 3 CD cord-010092-uftc8inx 8301 11 - - SYM cord-010092-uftc8inx 8301 12 4 4 CD cord-010092-uftc8inx 8301 13 days day NNS cord-010092-uftc8inx 8301 14 post post NN cord-010092-uftc8inx 8301 15 - - NN cord-010092-uftc8inx 8301 16 collection collection NN cord-010092-uftc8inx 8301 17 in in IN cord-010092-uftc8inx 8301 18 all all DT cord-010092-uftc8inx 8301 19 PLT PLT NNP cord-010092-uftc8inx 8301 20 aliquots aliquot NNS cord-010092-uftc8inx 8301 21 stored store VBN cord-010092-uftc8inx 8301 22 at at IN cord-010092-uftc8inx 8301 23 RT RT NNP cord-010092-uftc8inx 8301 24 except except IN cord-010092-uftc8inx 8301 25 those those DT cord-010092-uftc8inx 8301 26 challenged challenge VBN cord-010092-uftc8inx 8301 27 with with IN cord-010092-uftc8inx 8301 28 S. S. NNP cord-010092-uftc8inx 8301 29 epidermidis epidermidi NNS cord-010092-uftc8inx 8301 30 . . . cord-010092-uftc8inx 8302 1 Significant significant JJ cord-010092-uftc8inx 8302 2 growth growth NN cord-010092-uftc8inx 8302 3 of of IN cord-010092-uftc8inx 8302 4 S. S. NNP cord-010092-uftc8inx 8302 5 epidermidis epidermidi NNS cord-010092-uftc8inx 8302 6 was be VBD cord-010092-uftc8inx 8302 7 not not RB cord-010092-uftc8inx 8302 8 detected detect VBN cord-010092-uftc8inx 8302 9 until until IN cord-010092-uftc8inx 8302 10 day day NN cord-010092-uftc8inx 8302 11 4 4 CD cord-010092-uftc8inx 8302 12 . . . cord-010092-uftc8inx 8303 1 Bacterial bacterial JJ cord-010092-uftc8inx 8303 2 numbers number NNS cord-010092-uftc8inx 8303 3 remained remain VBD cord-010092-uftc8inx 8303 4 unchanged unchanged JJ cord-010092-uftc8inx 8303 5 in in IN cord-010092-uftc8inx 8303 6 refrigerated refrigerated JJ cord-010092-uftc8inx 8303 7 aliquots aliquot NNS cord-010092-uftc8inx 8303 8 through through IN cord-010092-uftc8inx 8303 9 day day NN cord-010092-uftc8inx 8303 10 5 5 CD cord-010092-uftc8inx 8303 11 . . . cord-010092-uftc8inx 8304 1 RT RT NNP cord-010092-uftc8inx 8304 2 storage storage NN cord-010092-uftc8inx 8304 3 resulted result VBD cord-010092-uftc8inx 8304 4 in in IN cord-010092-uftc8inx 8304 5 significantly significantly RB cord-010092-uftc8inx 8304 6 ( ( -LRB- cord-010092-uftc8inx 8304 7 P p NN cord-010092-uftc8inx 8304 8 < < XX cord-010092-uftc8inx 8304 9 0.05 0.05 CD cord-010092-uftc8inx 8304 10 ) ) -RRB- cord-010092-uftc8inx 8304 11 decreased decrease VBD cord-010092-uftc8inx 8304 12 platelet platelet NN cord-010092-uftc8inx 8304 13 aggregation aggregation NN cord-010092-uftc8inx 8304 14 over over IN cord-010092-uftc8inx 8304 15 time time NN cord-010092-uftc8inx 8304 16 which which WDT cord-010092-uftc8inx 8304 17 was be VBD cord-010092-uftc8inx 8304 18 exacerbated exacerbate VBN cord-010092-uftc8inx 8304 19 by by IN cord-010092-uftc8inx 8304 20 bacterial bacterial JJ cord-010092-uftc8inx 8304 21 challenge challenge NN cord-010092-uftc8inx 8304 22 . . . cord-010092-uftc8inx 8305 1 PLT PLT NNP cord-010092-uftc8inx 8305 2 function function NN cord-010092-uftc8inx 8305 3 was be VBD cord-010092-uftc8inx 8305 4 largely largely RB cord-010092-uftc8inx 8305 5 preserved preserve VBN cord-010092-uftc8inx 8305 6 with with IN cord-010092-uftc8inx 8305 7 refrigeration refrigeration NN cord-010092-uftc8inx 8305 8 regardless regardless RB cord-010092-uftc8inx 8305 9 of of IN cord-010092-uftc8inx 8305 10 challenge challenge NN cord-010092-uftc8inx 8305 11 . . . cord-010092-uftc8inx 8306 1 Bacterial bacterial JJ cord-010092-uftc8inx 8306 2 growth growth NN cord-010092-uftc8inx 8306 3 was be VBD cord-010092-uftc8inx 8306 4 significantly significantly RB cord-010092-uftc8inx 8306 5 reduced reduce VBN cord-010092-uftc8inx 8306 6 , , , cord-010092-uftc8inx 8306 7 or or CC cord-010092-uftc8inx 8306 8 at at IN cord-010092-uftc8inx 8306 9 least least JJS cord-010092-uftc8inx 8306 10 delayed delay VBN cord-010092-uftc8inx 8306 11 , , , cord-010092-uftc8inx 8306 12 in in IN cord-010092-uftc8inx 8306 13 FP FP NNP cord-010092-uftc8inx 8306 14 . . . cord-010092-uftc8inx 8307 1 FP FP NNP cord-010092-uftc8inx 8307 2 challenged challenge VBD cord-010092-uftc8inx 8307 3 with with IN cord-010092-uftc8inx 8307 4 Gram gram NN cord-010092-uftc8inx 8307 5 - - HYPH cord-010092-uftc8inx 8307 6 negative negative JJ cord-010092-uftc8inx 8307 7 pathogens pathogen NNS cord-010092-uftc8inx 8307 8 exhibited exhibit VBD cord-010092-uftc8inx 8307 9 a a DT cord-010092-uftc8inx 8307 10 significant significant JJ cord-010092-uftc8inx 8307 11 ( ( -LRB- cord-010092-uftc8inx 8307 12 P p NN cord-010092-uftc8inx 8307 13 < < XX cord-010092-uftc8inx 8307 14 0.05 0.05 CD cord-010092-uftc8inx 8307 15 ) ) -RRB- cord-010092-uftc8inx 8307 16 delay delay VBP cord-010092-uftc8inx 8307 17 in in IN cord-010092-uftc8inx 8307 18 bacterial bacterial JJ cord-010092-uftc8inx 8307 19 growth growth NN cord-010092-uftc8inx 8307 20 at at IN cord-010092-uftc8inx 8307 21 day day NN cord-010092-uftc8inx 8307 22 1 1 CD cord-010092-uftc8inx 8307 23 . . . cord-010092-uftc8inx 8308 1 While while IN cord-010092-uftc8inx 8308 2 growth growth NN cord-010092-uftc8inx 8308 3 of of IN cord-010092-uftc8inx 8308 4 E. E. NNP cord-010092-uftc8inx 8308 5 coli coli NNS cord-010092-uftc8inx 8308 6 and and CC cord-010092-uftc8inx 8308 7 P. P. NNP cord-010092-uftc8inx 8308 8 aeruginosa aeruginosa NN cord-010092-uftc8inx 8308 9 recovered recover VBN cord-010092-uftc8inx 8308 10 by by IN cord-010092-uftc8inx 8308 11 day day NN cord-010092-uftc8inx 8308 12 2 2 CD cord-010092-uftc8inx 8308 13 , , , cord-010092-uftc8inx 8308 14 growth growth NN cord-010092-uftc8inx 8308 15 of of IN cord-010092-uftc8inx 8308 16 A. a. NN cord-010092-uftc8inx 8308 17 baumannii baumannii NNP cord-010092-uftc8inx 8308 18 was be VBD cord-010092-uftc8inx 8308 19 significantly significantly RB cord-010092-uftc8inx 8308 20 ( ( -LRB- cord-010092-uftc8inx 8308 21 P p NN cord-010092-uftc8inx 8308 22 < < XX cord-010092-uftc8inx 8308 23 0.05 0.05 CD cord-010092-uftc8inx 8308 24 ) ) -RRB- cord-010092-uftc8inx 8308 25 inhibited inhibit VBN cord-010092-uftc8inx 8308 26 throughout throughout IN cord-010092-uftc8inx 8308 27 . . . cord-010092-uftc8inx 8309 1 FP FP NNP cord-010092-uftc8inx 8309 2 challenged challenge VBD cord-010092-uftc8inx 8309 3 with with IN cord-010092-uftc8inx 8309 4 Gram gram NN cord-010092-uftc8inx 8309 5 - - HYPH cord-010092-uftc8inx 8309 6 positive positive JJ cord-010092-uftc8inx 8309 7 pathogens pathogen NNS cord-010092-uftc8inx 8309 8 exhibited exhibit VBD cord-010092-uftc8inx 8309 9 significant significant JJ cord-010092-uftc8inx 8309 10 ( ( -LRB- cord-010092-uftc8inx 8309 11 P p NN cord-010092-uftc8inx 8309 12 < < XX cord-010092-uftc8inx 8309 13 0.05 0.05 CD cord-010092-uftc8inx 8309 14 ) ) -RRB- cord-010092-uftc8inx 8309 15 reduction reduction NN cord-010092-uftc8inx 8309 16 in in IN cord-010092-uftc8inx 8309 17 bacterial bacterial JJ cord-010092-uftc8inx 8309 18 growth growth NN cord-010092-uftc8inx 8309 19 relative relative JJ cord-010092-uftc8inx 8309 20 to to IN cord-010092-uftc8inx 8309 21 PLT PLT NNP cord-010092-uftc8inx 8309 22 aliquots aliquot NNS cord-010092-uftc8inx 8309 23 . . . cord-010092-uftc8inx 8310 1 Bacterial bacterial JJ cord-010092-uftc8inx 8310 2 growth growth NN cord-010092-uftc8inx 8310 3 correlated correlate VBN cord-010092-uftc8inx 8310 4 with with IN cord-010092-uftc8inx 8310 5 PLT PLT NNP cord-010092-uftc8inx 8310 6 lactate lactate NN cord-010092-uftc8inx 8310 7 production production NN cord-010092-uftc8inx 8310 8 . . . cord-010092-uftc8inx 8311 1 Lactate lactate NN cord-010092-uftc8inx 8311 2 levels level NNS cord-010092-uftc8inx 8311 3 in in IN cord-010092-uftc8inx 8311 4 PLTs plt NNS cord-010092-uftc8inx 8311 5 challenged challenge VBN cord-010092-uftc8inx 8311 6 with with IN cord-010092-uftc8inx 8311 7 E. E. NNP cord-010092-uftc8inx 8311 8 coli coli NNS cord-010092-uftc8inx 8311 9 showed show VBD cord-010092-uftc8inx 8311 10 diminished diminish VBN cord-010092-uftc8inx 8311 11 significantly significantly RB cord-010092-uftc8inx 8311 12 after after IN cord-010092-uftc8inx 8311 13 day day NN cord-010092-uftc8inx 8311 14 3 3 CD cord-010092-uftc8inx 8311 15 , , , cord-010092-uftc8inx 8311 16 indicative indicative JJ cord-010092-uftc8inx 8311 17 of of IN cord-010092-uftc8inx 8311 18 lactate lactate NN cord-010092-uftc8inx 8311 19 utilization utilization NN cord-010092-uftc8inx 8311 20 . . . cord-010092-uftc8inx 8312 1 With with IN cord-010092-uftc8inx 8312 2 exception exception NN cord-010092-uftc8inx 8312 3 of of IN cord-010092-uftc8inx 8312 4 FP FP NNP cord-010092-uftc8inx 8312 5 challenged challenge VBD cord-010092-uftc8inx 8312 6 with with IN cord-010092-uftc8inx 8312 7 S. S. NNP cord-010092-uftc8inx 8312 8 aureus aureus NN cord-010092-uftc8inx 8312 9 , , , cord-010092-uftc8inx 8312 10 bacterial bacterial JJ cord-010092-uftc8inx 8312 11 growth growth NN cord-010092-uftc8inx 8312 12 was be VBD cord-010092-uftc8inx 8312 13 restored restore VBN cord-010092-uftc8inx 8312 14 in in IN cord-010092-uftc8inx 8312 15 FP FP NNP cord-010092-uftc8inx 8312 16 supplemented supplement VBN cord-010092-uftc8inx 8312 17 with with IN cord-010092-uftc8inx 8312 18 lactic lactic JJ cord-010092-uftc8inx 8312 19 acid acid NN cord-010092-uftc8inx 8312 20 in in IN cord-010092-uftc8inx 8312 21 all all DT cord-010092-uftc8inx 8312 22 challenge challenge NN cord-010092-uftc8inx 8312 23 groups group NNS cord-010092-uftc8inx 8312 24 . . . cord-010092-uftc8inx 8313 1 Summary Summary NNP cord-010092-uftc8inx 8313 2 / / SYM cord-010092-uftc8inx 8313 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 8313 4 : : : cord-010092-uftc8inx 8314 1 Refrigeration refrigeration NN cord-010092-uftc8inx 8314 2 preserved preserve VBD cord-010092-uftc8inx 8314 3 platelet platelet NN cord-010092-uftc8inx 8314 4 function function NN cord-010092-uftc8inx 8314 5 while while IN cord-010092-uftc8inx 8314 6 both both CC cord-010092-uftc8inx 8314 7 inhibiting inhibit VBG cord-010092-uftc8inx 8314 8 bacterial bacterial JJ cord-010092-uftc8inx 8314 9 growth growth NN cord-010092-uftc8inx 8314 10 and and CC cord-010092-uftc8inx 8314 11 lactate lactate NN cord-010092-uftc8inx 8314 12 production production NN cord-010092-uftc8inx 8314 13 . . . cord-010092-uftc8inx 8315 1 Conversely conversely RB cord-010092-uftc8inx 8315 2 , , , cord-010092-uftc8inx 8315 3 the the DT cord-010092-uftc8inx 8315 4 opposite opposite NN cord-010092-uftc8inx 8315 5 was be VBD cord-010092-uftc8inx 8315 6 observed observe VBN cord-010092-uftc8inx 8315 7 with with IN cord-010092-uftc8inx 8315 8 RT RT NNP cord-010092-uftc8inx 8315 9 storage storage NN cord-010092-uftc8inx 8315 10 . . . cord-010092-uftc8inx 8316 1 These these DT cord-010092-uftc8inx 8316 2 data datum NNS cord-010092-uftc8inx 8316 3 demonstrate demonstrate VBP cord-010092-uftc8inx 8316 4 that that IN cord-010092-uftc8inx 8316 5 bacterial bacterial JJ cord-010092-uftc8inx 8316 6 growth growth NN cord-010092-uftc8inx 8316 7 can can MD cord-010092-uftc8inx 8316 8 be be VB cord-010092-uftc8inx 8316 9 controlled control VBN cord-010092-uftc8inx 8316 10 through through IN cord-010092-uftc8inx 8316 11 refrigeration refrigeration NN cord-010092-uftc8inx 8316 12 without without IN cord-010092-uftc8inx 8316 13 loss loss NN cord-010092-uftc8inx 8316 14 of of IN cord-010092-uftc8inx 8316 15 function function NN cord-010092-uftc8inx 8316 16 and and CC cord-010092-uftc8inx 8316 17 RT RT NNP cord-010092-uftc8inx 8316 18 storage storage NN cord-010092-uftc8inx 8316 19 may may MD cord-010092-uftc8inx 8316 20 potentiate potentiate VB cord-010092-uftc8inx 8316 21 growth growth NN cord-010092-uftc8inx 8316 22 of of IN cord-010092-uftc8inx 8316 23 certain certain JJ cord-010092-uftc8inx 8316 24 bacterial bacterial JJ cord-010092-uftc8inx 8316 25 strains strain NNS cord-010092-uftc8inx 8316 26 through through IN cord-010092-uftc8inx 8316 27 accelerated accelerate VBN cord-010092-uftc8inx 8316 28 PLT PLT NNP cord-010092-uftc8inx 8316 29 metabolism metabolism NN cord-010092-uftc8inx 8316 30 . . . cord-010092-uftc8inx 8317 1 Background background NN cord-010092-uftc8inx 8317 2 : : : cord-010092-uftc8inx 8318 1 Bacterial bacterial JJ cord-010092-uftc8inx 8318 2 contamination contamination NN cord-010092-uftc8inx 8318 3 of of IN cord-010092-uftc8inx 8318 4 peripheral peripheral JJ cord-010092-uftc8inx 8318 5 blood blood NN cord-010092-uftc8inx 8318 6 progenitor progenitor NN cord-010092-uftc8inx 8318 7 cell cell NN cord-010092-uftc8inx 8318 8 ( ( -LRB- cord-010092-uftc8inx 8318 9 PBPC PBPC NNP cord-010092-uftc8inx 8318 10 ) ) -RRB- cord-010092-uftc8inx 8318 11 for for IN cord-010092-uftc8inx 8318 12 transfusion transfusion NN cord-010092-uftc8inx 8318 13 has have VBZ cord-010092-uftc8inx 8318 14 been be VBN cord-010092-uftc8inx 8318 15 the the DT cord-010092-uftc8inx 8318 16 cause cause NN cord-010092-uftc8inx 8318 17 of of IN cord-010092-uftc8inx 8318 18 serious serious JJ cord-010092-uftc8inx 8318 19 sepsis sepsis NN cord-010092-uftc8inx 8318 20 and and CC cord-010092-uftc8inx 8318 21 life life NN cord-010092-uftc8inx 8318 22 - - HYPH cord-010092-uftc8inx 8318 23 threatening threaten VBG cord-010092-uftc8inx 8318 24 infections infection NNS cord-010092-uftc8inx 8318 25 . . . cord-010092-uftc8inx 8319 1 However however RB cord-010092-uftc8inx 8319 2 , , , cord-010092-uftc8inx 8319 3 a a DT cord-010092-uftc8inx 8319 4 standard standard JJ cord-010092-uftc8inx 8319 5 procedure procedure NN cord-010092-uftc8inx 8319 6 or or CC cord-010092-uftc8inx 8319 7 choice choice NN cord-010092-uftc8inx 8319 8 of of IN cord-010092-uftc8inx 8319 9 test test NN cord-010092-uftc8inx 8319 10 sample(s sample(s NNP cord-010092-uftc8inx 8319 11 ) ) -RRB- cord-010092-uftc8inx 8319 12 has have VBZ cord-010092-uftc8inx 8319 13 not not RB cord-010092-uftc8inx 8319 14 been be VBN cord-010092-uftc8inx 8319 15 established establish VBN cord-010092-uftc8inx 8319 16 to to TO cord-010092-uftc8inx 8319 17 screen screen VB cord-010092-uftc8inx 8319 18 PBPC PBPC NNP cord-010092-uftc8inx 8319 19 products product NNS cord-010092-uftc8inx 8319 20 for for IN cord-010092-uftc8inx 8319 21 microbial microbial JJ cord-010092-uftc8inx 8319 22 contamination contamination NN cord-010092-uftc8inx 8319 23 , , , cord-010092-uftc8inx 8319 24 because because IN cord-010092-uftc8inx 8319 25 these these DT cord-010092-uftc8inx 8319 26 products product NNS cord-010092-uftc8inx 8319 27 are be VBP cord-010092-uftc8inx 8319 28 not not RB cord-010092-uftc8inx 8319 29 large large JJ cord-010092-uftc8inx 8319 30 enough enough RB cord-010092-uftc8inx 8319 31 to to TO cord-010092-uftc8inx 8319 32 facilitate facilitate VB cord-010092-uftc8inx 8319 33 inoculation inoculation NN cord-010092-uftc8inx 8319 34 of of IN cord-010092-uftc8inx 8319 35 the the DT cord-010092-uftc8inx 8319 36 recommended recommend VBN cord-010092-uftc8inx 8319 37 volume volume NN cord-010092-uftc8inx 8319 38 for for IN cord-010092-uftc8inx 8319 39 the the DT cord-010092-uftc8inx 8319 40 automated automate VBN cord-010092-uftc8inx 8319 41 blood blood NN cord-010092-uftc8inx 8319 42 culture culture NN cord-010092-uftc8inx 8319 43 systems system NNS cord-010092-uftc8inx 8319 44 . . . cord-010092-uftc8inx 8320 1 Samples sample NNS cord-010092-uftc8inx 8320 2 taken take VBN cord-010092-uftc8inx 8320 3 from from IN cord-010092-uftc8inx 8320 4 by by IN cord-010092-uftc8inx 8320 5 - - HYPH cord-010092-uftc8inx 8320 6 product product NN cord-010092-uftc8inx 8320 7 plasma plasma NN cord-010092-uftc8inx 8320 8 and and CC cord-010092-uftc8inx 8320 9 low low JJ cord-010092-uftc8inx 8320 10 volume volume NN cord-010092-uftc8inx 8320 11 PBPC PBPC NNP cord-010092-uftc8inx 8320 12 product product NN cord-010092-uftc8inx 8320 13 were be VBD cord-010092-uftc8inx 8320 14 cultured culture VBN cord-010092-uftc8inx 8320 15 in in IN cord-010092-uftc8inx 8320 16 routine routine JJ cord-010092-uftc8inx 8320 17 sterility sterility NN cord-010092-uftc8inx 8320 18 test test NN cord-010092-uftc8inx 8320 19 . . . cord-010092-uftc8inx 8321 1 Aims aim VBZ cord-010092-uftc8inx 8321 2 : : : cord-010092-uftc8inx 8321 3 To to TO cord-010092-uftc8inx 8321 4 evaluate evaluate VB cord-010092-uftc8inx 8321 5 the the DT cord-010092-uftc8inx 8321 6 residual residual JJ cord-010092-uftc8inx 8321 7 risk risk NN cord-010092-uftc8inx 8321 8 of of IN cord-010092-uftc8inx 8321 9 microbial microbial JJ cord-010092-uftc8inx 8321 10 contamination contamination NN cord-010092-uftc8inx 8321 11 in in IN cord-010092-uftc8inx 8321 12 PBPC PBPC NNP cord-010092-uftc8inx 8321 13 products product NNS cord-010092-uftc8inx 8321 14 for for IN cord-010092-uftc8inx 8321 15 transplantation transplantation NN cord-010092-uftc8inx 8321 16 , , , cord-010092-uftc8inx 8321 17 we -PRON- PRP cord-010092-uftc8inx 8321 18 cultured culture VBD cord-010092-uftc8inx 8321 19 sufficient sufficient JJ cord-010092-uftc8inx 8321 20 post post JJ cord-010092-uftc8inx 8321 21 - - JJ cord-010092-uftc8inx 8321 22 thaw thaw VB cord-010092-uftc8inx 8321 23 inoculation inoculation NN cord-010092-uftc8inx 8321 24 volumes volume NNS cord-010092-uftc8inx 8321 25 from from IN cord-010092-uftc8inx 8321 26 PBPC PBPC NNP cord-010092-uftc8inx 8321 27 products product NNS cord-010092-uftc8inx 8321 28 which which WDT cord-010092-uftc8inx 8321 29 were be VBD cord-010092-uftc8inx 8321 30 discarded discard VBN cord-010092-uftc8inx 8321 31 for for IN cord-010092-uftc8inx 8321 32 various various JJ cord-010092-uftc8inx 8321 33 reasons reason NNS cord-010092-uftc8inx 8321 34 in in IN cord-010092-uftc8inx 8321 35 our -PRON- PRP$ cord-010092-uftc8inx 8321 36 blood blood NN cord-010092-uftc8inx 8321 37 center center NN cord-010092-uftc8inx 8321 38 . . . cord-010092-uftc8inx 8322 1 Methods method NNS cord-010092-uftc8inx 8322 2 : : : cord-010092-uftc8inx 8322 3 In in IN cord-010092-uftc8inx 8322 4 routine routine JJ cord-010092-uftc8inx 8322 5 sterility sterility NN cord-010092-uftc8inx 8322 6 test test NN cord-010092-uftc8inx 8322 7 , , , cord-010092-uftc8inx 8322 8 a a DT cord-010092-uftc8inx 8322 9 20-mL 20-ml CD cord-010092-uftc8inx 8322 10 sample sample NN cord-010092-uftc8inx 8322 11 of of IN cord-010092-uftc8inx 8322 12 by by IN cord-010092-uftc8inx 8322 13 - - HYPH cord-010092-uftc8inx 8322 14 product product NN cord-010092-uftc8inx 8322 15 plasma plasma NN cord-010092-uftc8inx 8322 16 collected collect VBN cord-010092-uftc8inx 8322 17 with with IN cord-010092-uftc8inx 8322 18 PBPC PBPC NNP cord-010092-uftc8inx 8322 19 product product NN cord-010092-uftc8inx 8322 20 was be VBD cord-010092-uftc8inx 8322 21 inoculated inoculate VBN cord-010092-uftc8inx 8322 22 into into IN cord-010092-uftc8inx 8322 23 BacT BacT NNP cord-010092-uftc8inx 8322 24 / / SYM cord-010092-uftc8inx 8322 25 ALERT ALERT NNP cord-010092-uftc8inx 8322 26 BPA BPA NNP cord-010092-uftc8inx 8322 27 and and CC cord-010092-uftc8inx 8322 28 BPN BPN NNP cord-010092-uftc8inx 8322 29 culture culture NN cord-010092-uftc8inx 8322 30 bottle bottle NN cord-010092-uftc8inx 8322 31 ( ( -LRB- cord-010092-uftc8inx 8322 32 10 10 CD cord-010092-uftc8inx 8322 33 mL ml NN cord-010092-uftc8inx 8322 34 each each DT cord-010092-uftc8inx 8322 35 ) ) -RRB- cord-010092-uftc8inx 8322 36 within within IN cord-010092-uftc8inx 8322 37 48 48 CD cord-010092-uftc8inx 8322 38 h h NN cord-010092-uftc8inx 8322 39 after after IN cord-010092-uftc8inx 8322 40 collection collection NN cord-010092-uftc8inx 8322 41 . . . cord-010092-uftc8inx 8323 1 The the DT cord-010092-uftc8inx 8323 2 bottles bottle NNS cord-010092-uftc8inx 8323 3 were be VBD cord-010092-uftc8inx 8323 4 then then RB cord-010092-uftc8inx 8323 5 placed place VBN cord-010092-uftc8inx 8323 6 in in IN cord-010092-uftc8inx 8323 7 the the DT cord-010092-uftc8inx 8323 8 BacT/ BacT/ NNP cord-010092-uftc8inx 8323 9 ALERT ALERT NNP cord-010092-uftc8inx 8323 10 system system NN cord-010092-uftc8inx 8323 11 and and CC cord-010092-uftc8inx 8323 12 incubated incubate VBN cord-010092-uftc8inx 8323 13 for for IN cord-010092-uftc8inx 8323 14 at at RB cord-010092-uftc8inx 8323 15 least least JJS cord-010092-uftc8inx 8323 16 7 7 CD cord-010092-uftc8inx 8323 17 days day NNS cord-010092-uftc8inx 8323 18 or or CC cord-010092-uftc8inx 8323 19 when when WRB cord-010092-uftc8inx 8323 20 a a DT cord-010092-uftc8inx 8323 21 positive positive JJ cord-010092-uftc8inx 8323 22 reaction reaction NN cord-010092-uftc8inx 8323 23 was be VBD cord-010092-uftc8inx 8323 24 indicated indicate VBN cord-010092-uftc8inx 8323 25 by by IN cord-010092-uftc8inx 8323 26 the the DT cord-010092-uftc8inx 8323 27 automated automate VBN cord-010092-uftc8inx 8323 28 liquid liquid JJ cord-010092-uftc8inx 8323 29 - - HYPH cord-010092-uftc8inx 8323 30 media media NN cord-010092-uftc8inx 8323 31 culture culture NN cord-010092-uftc8inx 8323 32 system system NN cord-010092-uftc8inx 8323 33 . . . cord-010092-uftc8inx 8324 1 Moreover moreover RB cord-010092-uftc8inx 8324 2 , , , cord-010092-uftc8inx 8324 3 a a DT cord-010092-uftc8inx 8324 4 2-mL 2-ml CD cord-010092-uftc8inx 8324 5 postthaw postthaw NNP cord-010092-uftc8inx 8324 6 sample sample NN cord-010092-uftc8inx 8324 7 would would MD cord-010092-uftc8inx 8324 8 be be VB cord-010092-uftc8inx 8324 9 cultured culture VBN cord-010092-uftc8inx 8324 10 before before IN cord-010092-uftc8inx 8324 11 transplantation transplantation NN cord-010092-uftc8inx 8324 12 performed perform VBN cord-010092-uftc8inx 8324 13 . . . cord-010092-uftc8inx 8325 1 In in IN cord-010092-uftc8inx 8325 2 the the DT cord-010092-uftc8inx 8325 3 residual residual JJ cord-010092-uftc8inx 8325 4 risk risk NN cord-010092-uftc8inx 8325 5 investigation investigation NN cord-010092-uftc8inx 8325 6 , , , cord-010092-uftc8inx 8325 7 discarded discard VBN cord-010092-uftc8inx 8325 8 PBPC PBPC NNP cord-010092-uftc8inx 8325 9 products product NNS cord-010092-uftc8inx 8325 10 were be VBD cord-010092-uftc8inx 8325 11 thawed thaw VBN cord-010092-uftc8inx 8325 12 , , , cord-010092-uftc8inx 8325 13 and and CC cord-010092-uftc8inx 8325 14 then then RB cord-010092-uftc8inx 8325 15 a a DT cord-010092-uftc8inx 8325 16 2-mL 2-ml CD cord-010092-uftc8inx 8325 17 and and CC cord-010092-uftc8inx 8325 18 a a DT cord-010092-uftc8inx 8325 19 20-mL 20-ml CD cord-010092-uftc8inx 8325 20 aliquot aliquot NN cord-010092-uftc8inx 8325 21 were be VBD cord-010092-uftc8inx 8325 22 taken take VBN cord-010092-uftc8inx 8325 23 and and CC cord-010092-uftc8inx 8325 24 cultured culture VBN cord-010092-uftc8inx 8325 25 with with IN cord-010092-uftc8inx 8325 26 the the DT cord-010092-uftc8inx 8325 27 same same JJ cord-010092-uftc8inx 8325 28 method method NN cord-010092-uftc8inx 8325 29 . . . cord-010092-uftc8inx 8326 1 All all DT cord-010092-uftc8inx 8326 2 positive positive JJ cord-010092-uftc8inx 8326 3 bottles bottle NNS cord-010092-uftc8inx 8326 4 were be VBD cord-010092-uftc8inx 8326 5 subcultured subculture VBN cord-010092-uftc8inx 8326 6 for for IN cord-010092-uftc8inx 8326 7 bacterial bacterial JJ cord-010092-uftc8inx 8326 8 isolation isolation NN cord-010092-uftc8inx 8326 9 and and CC cord-010092-uftc8inx 8326 10 identification identification NN cord-010092-uftc8inx 8326 11 . . . cord-010092-uftc8inx 8327 1 Results result NNS cord-010092-uftc8inx 8327 2 : : : cord-010092-uftc8inx 8328 1 In in IN cord-010092-uftc8inx 8328 2 September September NNP cord-010092-uftc8inx 8328 3 2008 2008 CD cord-010092-uftc8inx 8328 4 and and CC cord-010092-uftc8inx 8328 5 March March NNP cord-010092-uftc8inx 8328 6 2018 2018 CD cord-010092-uftc8inx 8328 7 , , , cord-010092-uftc8inx 8328 8 after after IN cord-010092-uftc8inx 8328 9 maintaining maintain VBG cord-010092-uftc8inx 8328 10 in in IN cord-010092-uftc8inx 8328 11 liquid liquid JJ cord-010092-uftc8inx 8328 12 nitrogen nitrogen NN cord-010092-uftc8inx 8328 13 for for IN cord-010092-uftc8inx 8328 14 1 1 CD cord-010092-uftc8inx 8328 15 to to TO cord-010092-uftc8inx 8328 16 17 17 CD cord-010092-uftc8inx 8328 17 years year NNS cord-010092-uftc8inx 8328 18 , , , cord-010092-uftc8inx 8328 19 205 205 CD cord-010092-uftc8inx 8328 20 PBPC PBPC NNP cord-010092-uftc8inx 8328 21 products product NNS cord-010092-uftc8inx 8328 22 collected collect VBD cord-010092-uftc8inx 8328 23 from from IN cord-010092-uftc8inx 8328 24 45 45 CD cord-010092-uftc8inx 8328 25 patients patient NNS cord-010092-uftc8inx 8328 26 , , , cord-010092-uftc8inx 8328 27 which which WDT cord-010092-uftc8inx 8328 28 was be VBD cord-010092-uftc8inx 8328 29 preserved preserve VBN cord-010092-uftc8inx 8328 30 in in IN cord-010092-uftc8inx 8328 31 a a DT cord-010092-uftc8inx 8328 32 volume volume NN cord-010092-uftc8inx 8328 33 between between IN cord-010092-uftc8inx 8328 34 35 35 CD cord-010092-uftc8inx 8328 35 and and CC cord-010092-uftc8inx 8328 36 60 60 CD cord-010092-uftc8inx 8328 37 mL ml NN cord-010092-uftc8inx 8328 38 , , , cord-010092-uftc8inx 8328 39 were be VBD cord-010092-uftc8inx 8328 40 discarded discard VBN cord-010092-uftc8inx 8328 41 . . . cord-010092-uftc8inx 8329 1 All all DT cord-010092-uftc8inx 8329 2 of of IN cord-010092-uftc8inx 8329 3 these these DT cord-010092-uftc8inx 8329 4 products product NNS cord-010092-uftc8inx 8329 5 had have VBD cord-010092-uftc8inx 8329 6 been be VBN cord-010092-uftc8inx 8329 7 cultured culture VBN cord-010092-uftc8inx 8329 8 negative negative JJ cord-010092-uftc8inx 8329 9 in in IN cord-010092-uftc8inx 8329 10 routine routine JJ cord-010092-uftc8inx 8329 11 sterility sterility NN cord-010092-uftc8inx 8329 12 tests test NNS cord-010092-uftc8inx 8329 13 with with IN cord-010092-uftc8inx 8329 14 plasma plasma NN cord-010092-uftc8inx 8329 15 samples sample NNS cord-010092-uftc8inx 8329 16 . . . cord-010092-uftc8inx 8330 1 These these DT cord-010092-uftc8inx 8330 2 205 205 CD cord-010092-uftc8inx 8330 3 final final JJ cord-010092-uftc8inx 8330 4 products product NNS cord-010092-uftc8inx 8330 5 were be VBD cord-010092-uftc8inx 8330 6 thawed thaw VBN cord-010092-uftc8inx 8330 7 and and CC cord-010092-uftc8inx 8330 8 cultured culture VBN cord-010092-uftc8inx 8330 9 with with IN cord-010092-uftc8inx 8330 10 both both CC cord-010092-uftc8inx 8330 11 the the DT cord-010092-uftc8inx 8330 12 20-mL 20-ml CD cord-010092-uftc8inx 8330 13 and and CC cord-010092-uftc8inx 8330 14 the the DT cord-010092-uftc8inx 8330 15 2-mL 2-ml CD cord-010092-uftc8inx 8330 16 aliquot aliquot NN cord-010092-uftc8inx 8330 17 . . . cord-010092-uftc8inx 8331 1 One one CD cord-010092-uftc8inx 8331 2 of of IN cord-010092-uftc8inx 8331 3 these these DT cord-010092-uftc8inx 8331 4 PBPC PBPC NNP cord-010092-uftc8inx 8331 5 products product NNS cord-010092-uftc8inx 8331 6 had have VBD cord-010092-uftc8inx 8331 7 the the DT cord-010092-uftc8inx 8331 8 positive positive JJ cord-010092-uftc8inx 8331 9 culture culture NN cord-010092-uftc8inx 8331 10 result result VB cord-010092-uftc8inx 8331 11 with with IN cord-010092-uftc8inx 8331 12 the the DT cord-010092-uftc8inx 8331 13 20-mL 20-ml CD cord-010092-uftc8inx 8331 14 retested reteste VBN cord-010092-uftc8inx 8331 15 samples sample NNS cord-010092-uftc8inx 8331 16 . . . cord-010092-uftc8inx 8332 1 Nevertheless nevertheless RB cord-010092-uftc8inx 8332 2 , , , cord-010092-uftc8inx 8332 3 the the DT cord-010092-uftc8inx 8332 4 same same JJ cord-010092-uftc8inx 8332 5 PBPC PBPC NNP cord-010092-uftc8inx 8332 6 product product NN cord-010092-uftc8inx 8332 7 had have VBD cord-010092-uftc8inx 8332 8 the the DT cord-010092-uftc8inx 8332 9 negative negative JJ cord-010092-uftc8inx 8332 10 result result NN cord-010092-uftc8inx 8332 11 with with IN cord-010092-uftc8inx 8332 12 the the DT cord-010092-uftc8inx 8332 13 2-mL 2-ml CD cord-010092-uftc8inx 8332 14 post post NN cord-010092-uftc8inx 8332 15 - - JJ cord-010092-uftc8inx 8332 16 thaw thaw JJ cord-010092-uftc8inx 8332 17 PBPC PBPC NNP cord-010092-uftc8inx 8332 18 sample sample NN cord-010092-uftc8inx 8332 19 and and CC cord-010092-uftc8inx 8332 20 the the DT cord-010092-uftc8inx 8332 21 20-mL 20-ml CD cord-010092-uftc8inx 8332 22 by by IN cord-010092-uftc8inx 8332 23 - - HYPH cord-010092-uftc8inx 8332 24 product product NN cord-010092-uftc8inx 8332 25 plasma plasma NN cord-010092-uftc8inx 8332 26 sample sample NN cord-010092-uftc8inx 8332 27 . . . cord-010092-uftc8inx 8333 1 Propionibacterium propionibacterium NN cord-010092-uftc8inx 8333 2 acnes acne NNS cord-010092-uftc8inx 8333 3 was be VBD cord-010092-uftc8inx 8333 4 isolated isolate VBN cord-010092-uftc8inx 8333 5 from from IN cord-010092-uftc8inx 8333 6 the the DT cord-010092-uftc8inx 8333 7 BPN BPN NNP cord-010092-uftc8inx 8333 8 positive positive JJ cord-010092-uftc8inx 8333 9 bottle bottle NN cord-010092-uftc8inx 8333 10 . . . cord-010092-uftc8inx 8334 1 Summary Summary NNP cord-010092-uftc8inx 8334 2 / / SYM cord-010092-uftc8inx 8334 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 8334 4 : : : cord-010092-uftc8inx 8335 1 The the DT cord-010092-uftc8inx 8335 2 residual residual JJ cord-010092-uftc8inx 8335 3 risk risk NN cord-010092-uftc8inx 8335 4 of of IN cord-010092-uftc8inx 8335 5 microbial microbial JJ cord-010092-uftc8inx 8335 6 contamination contamination NN cord-010092-uftc8inx 8335 7 in in IN cord-010092-uftc8inx 8335 8 PBPC PBPC NNP cord-010092-uftc8inx 8335 9 postthaw postthaw NNP cord-010092-uftc8inx 8335 10 products product NNS cord-010092-uftc8inx 8335 11 still still RB cord-010092-uftc8inx 8335 12 exist exist VBP cord-010092-uftc8inx 8335 13 after after IN cord-010092-uftc8inx 8335 14 routine routine JJ cord-010092-uftc8inx 8335 15 sterility sterility NN cord-010092-uftc8inx 8335 16 test test NN cord-010092-uftc8inx 8335 17 with with IN cord-010092-uftc8inx 8335 18 the the DT cord-010092-uftc8inx 8335 19 plasma plasma NN cord-010092-uftc8inx 8335 20 sample sample NN cord-010092-uftc8inx 8335 21 and and CC cord-010092-uftc8inx 8335 22 the the DT cord-010092-uftc8inx 8335 23 2-mL 2-ml CD cord-010092-uftc8inx 8335 24 volume volume NN cord-010092-uftc8inx 8335 25 of of IN cord-010092-uftc8inx 8335 26 PBPC PBPC NNP cord-010092-uftc8inx 8335 27 sample sample NN cord-010092-uftc8inx 8335 28 . . . cord-010092-uftc8inx 8336 1 The the DT cord-010092-uftc8inx 8336 2 bacterium bacterium NN cord-010092-uftc8inx 8336 3 isolated isolate VBN cord-010092-uftc8inx 8336 4 from from IN cord-010092-uftc8inx 8336 5 PBPC PBPC NNP cord-010092-uftc8inx 8336 6 product product NN cord-010092-uftc8inx 8336 7 was be VBD cord-010092-uftc8inx 8336 8 normal normal JJ cord-010092-uftc8inx 8336 9 skin skin NN cord-010092-uftc8inx 8336 10 flora flora NN cord-010092-uftc8inx 8336 11 bacterium bacterium NN cord-010092-uftc8inx 8336 12 . . . cord-010092-uftc8inx 8337 1 An an DT cord-010092-uftc8inx 8337 2 optimal optimal JJ cord-010092-uftc8inx 8337 3 screening screening NN cord-010092-uftc8inx 8337 4 method method NN cord-010092-uftc8inx 8337 5 of of IN cord-010092-uftc8inx 8337 6 PBPC PBPC NNP cord-010092-uftc8inx 8337 7 products product NNS cord-010092-uftc8inx 8337 8 merits merit VBZ cord-010092-uftc8inx 8337 9 further further JJ cord-010092-uftc8inx 8337 10 study study NN cord-010092-uftc8inx 8337 11 to to TO cord-010092-uftc8inx 8337 12 increase increase VB cord-010092-uftc8inx 8337 13 the the DT cord-010092-uftc8inx 8337 14 safety safety NN cord-010092-uftc8inx 8337 15 of of IN cord-010092-uftc8inx 8337 16 the the DT cord-010092-uftc8inx 8337 17 blood blood NN cord-010092-uftc8inx 8337 18 supply supply NN cord-010092-uftc8inx 8337 19 . . . cord-010092-uftc8inx 8338 1 Background background NN cord-010092-uftc8inx 8338 2 : : : cord-010092-uftc8inx 8339 1 Hospital hospital NN cord-010092-uftc8inx 8339 2 hygiene hygiene NN cord-010092-uftc8inx 8339 3 tools tool NNS cord-010092-uftc8inx 8339 4 that that WDT cord-010092-uftc8inx 8339 5 serve serve VBP cord-010092-uftc8inx 8339 6 as as IN cord-010092-uftc8inx 8339 7 a a DT cord-010092-uftc8inx 8339 8 proxy proxy NN cord-010092-uftc8inx 8339 9 for for IN cord-010092-uftc8inx 8339 10 assessment assessment NN cord-010092-uftc8inx 8339 11 of of IN cord-010092-uftc8inx 8339 12 microbial microbial JJ cord-010092-uftc8inx 8339 13 contamination contamination NN cord-010092-uftc8inx 8339 14 are be VBP cord-010092-uftc8inx 8339 15 increasingly increasingly RB cord-010092-uftc8inx 8339 16 used use VBN cord-010092-uftc8inx 8339 17 . . . cord-010092-uftc8inx 8340 1 They -PRON- PRP cord-010092-uftc8inx 8340 2 include include VBP cord-010092-uftc8inx 8340 3 adenosine adenosine NN cord-010092-uftc8inx 8340 4 triphosphate triphosphate NN cord-010092-uftc8inx 8340 5 ( ( -LRB- cord-010092-uftc8inx 8340 6 ATP ATP NNP cord-010092-uftc8inx 8340 7 ) ) -RRB- cord-010092-uftc8inx 8340 8 bioluminescence bioluminescence NN cord-010092-uftc8inx 8340 9 and and CC cord-010092-uftc8inx 8340 10 air air NN cord-010092-uftc8inx 8340 11 particle particle NN cord-010092-uftc8inx 8340 12 counting counting NN cord-010092-uftc8inx 8340 13 . . . cord-010092-uftc8inx 8341 1 However however RB cord-010092-uftc8inx 8341 2 , , , cord-010092-uftc8inx 8341 3 their -PRON- PRP$ cord-010092-uftc8inx 8341 4 use use NN cord-010092-uftc8inx 8341 5 for for IN cord-010092-uftc8inx 8341 6 microbial microbial JJ cord-010092-uftc8inx 8341 7 monitoring monitoring NN cord-010092-uftc8inx 8341 8 of of IN cord-010092-uftc8inx 8341 9 blood blood NN cord-010092-uftc8inx 8341 10 banks bank NNS cord-010092-uftc8inx 8341 11 remains remain VBZ cord-010092-uftc8inx 8341 12 underexplored underexplored JJ cord-010092-uftc8inx 8341 13 . . . cord-010092-uftc8inx 8342 1 They -PRON- PRP cord-010092-uftc8inx 8342 2 could could MD cord-010092-uftc8inx 8342 3 be be VB cord-010092-uftc8inx 8342 4 of of IN cord-010092-uftc8inx 8342 5 particular particular JJ cord-010092-uftc8inx 8342 6 interest interest NN cord-010092-uftc8inx 8342 7 in in IN cord-010092-uftc8inx 8342 8 a a DT cord-010092-uftc8inx 8342 9 sub sub JJ cord-010092-uftc8inx 8342 10 - - JJ cord-010092-uftc8inx 8342 11 Saharan saharan JJ cord-010092-uftc8inx 8342 12 African african JJ cord-010092-uftc8inx 8342 13 setting setting NN cord-010092-uftc8inx 8342 14 ( ( -LRB- cord-010092-uftc8inx 8342 15 temperatures temperature NNS cord-010092-uftc8inx 8342 16 , , , cord-010092-uftc8inx 8342 17 dust dust NN cord-010092-uftc8inx 8342 18 ) ) -RRB- cord-010092-uftc8inx 8342 19 to to TO cord-010092-uftc8inx 8342 20 circumvent circumvent VB cord-010092-uftc8inx 8342 21 bacterial bacterial JJ cord-010092-uftc8inx 8342 22 culture culture NN cord-010092-uftc8inx 8342 23 and and CC cord-010092-uftc8inx 8342 24 provide provide VB cord-010092-uftc8inx 8342 25 direct direct JJ cord-010092-uftc8inx 8342 26 results result NNS cord-010092-uftc8inx 8342 27 usable usable JJ cord-010092-uftc8inx 8342 28 for for IN cord-010092-uftc8inx 8342 29 monitoring monitor VBG cord-010092-uftc8inx 8342 30 over over IN cord-010092-uftc8inx 8342 31 time time NN cord-010092-uftc8inx 8342 32 . . . cord-010092-uftc8inx 8343 1 Aims aim VBZ cord-010092-uftc8inx 8343 2 : : : cord-010092-uftc8inx 8344 1 The the DT cord-010092-uftc8inx 8344 2 aim aim NN cord-010092-uftc8inx 8344 3 of of IN cord-010092-uftc8inx 8344 4 this this DT cord-010092-uftc8inx 8344 5 study study NN cord-010092-uftc8inx 8344 6 was be VBD cord-010092-uftc8inx 8344 7 ( ( -LRB- cord-010092-uftc8inx 8344 8 i i NN cord-010092-uftc8inx 8344 9 ) ) -RRB- cord-010092-uftc8inx 8344 10 to to TO cord-010092-uftc8inx 8344 11 quantify quantify VB cord-010092-uftc8inx 8344 12 environmental environmental JJ cord-010092-uftc8inx 8344 13 bacteria bacteria NNS cord-010092-uftc8inx 8344 14 in in IN cord-010092-uftc8inx 8344 15 the the DT cord-010092-uftc8inx 8344 16 air air NN cord-010092-uftc8inx 8344 17 and and CC cord-010092-uftc8inx 8344 18 on on IN cord-010092-uftc8inx 8344 19 surfaces surface NNS cord-010092-uftc8inx 8344 20 that that WDT cord-010092-uftc8inx 8344 21 are be VBP cord-010092-uftc8inx 8344 22 regularly regularly RB cord-010092-uftc8inx 8344 23 in in IN cord-010092-uftc8inx 8344 24 contact contact NN cord-010092-uftc8inx 8344 25 with with IN cord-010092-uftc8inx 8344 26 blood blood NN cord-010092-uftc8inx 8344 27 products product NNS cord-010092-uftc8inx 8344 28 , , , cord-010092-uftc8inx 8344 29 and and CC cord-010092-uftc8inx 8344 30 ( ( -LRB- cord-010092-uftc8inx 8344 31 ii ii NN cord-010092-uftc8inx 8344 32 ) ) -RRB- cord-010092-uftc8inx 8344 33 to to TO cord-010092-uftc8inx 8344 34 evaluate evaluate VB cord-010092-uftc8inx 8344 35 ATP ATP NNP cord-010092-uftc8inx 8344 36 bioluminescence bioluminescence NN cord-010092-uftc8inx 8344 37 techniques technique NNS cord-010092-uftc8inx 8344 38 and and CC cord-010092-uftc8inx 8344 39 particle particle NN cord-010092-uftc8inx 8344 40 counts count VBZ cord-010092-uftc8inx 8344 41 as as IN cord-010092-uftc8inx 8344 42 a a DT cord-010092-uftc8inx 8344 43 predictor predictor NN cord-010092-uftc8inx 8344 44 for for IN cord-010092-uftc8inx 8344 45 bacterial bacterial JJ cord-010092-uftc8inx 8344 46 contamination contamination NN cord-010092-uftc8inx 8344 47 , , , cord-010092-uftc8inx 8344 48 in in IN cord-010092-uftc8inx 8344 49 three three CD cord-010092-uftc8inx 8344 50 blood blood NN cord-010092-uftc8inx 8344 51 banks bank NNS cord-010092-uftc8inx 8344 52 in in IN cord-010092-uftc8inx 8344 53 the the DT cord-010092-uftc8inx 8344 54 Democratic Democratic NNP cord-010092-uftc8inx 8344 55 Republic Republic NNP cord-010092-uftc8inx 8344 56 of of IN cord-010092-uftc8inx 8344 57 the the DT cord-010092-uftc8inx 8344 58 Congo Congo NNP cord-010092-uftc8inx 8344 59 ( ( -LRB- cord-010092-uftc8inx 8344 60 DRC DRC NNP cord-010092-uftc8inx 8344 61 ) ) -RRB- cord-010092-uftc8inx 8344 62 . . . cord-010092-uftc8inx 8345 1 Methods method NNS cord-010092-uftc8inx 8345 2 : : : cord-010092-uftc8inx 8345 3 Samples sample NNS cord-010092-uftc8inx 8345 4 were be VBD cord-010092-uftc8inx 8345 5 taken take VBN cord-010092-uftc8inx 8345 6 in in IN cord-010092-uftc8inx 8345 7 three three CD cord-010092-uftc8inx 8345 8 blood blood NN cord-010092-uftc8inx 8345 9 banks bank NNS cord-010092-uftc8inx 8345 10 in in IN cord-010092-uftc8inx 8345 11 the the DT cord-010092-uftc8inx 8345 12 Democratic Democratic NNP cord-010092-uftc8inx 8345 13 Republic Republic NNP cord-010092-uftc8inx 8345 14 of of IN cord-010092-uftc8inx 8345 15 the the DT cord-010092-uftc8inx 8345 16 Congo Congo NNP cord-010092-uftc8inx 8345 17 : : : cord-010092-uftc8inx 8345 18 Hôpital Hôpital NNP cord-010092-uftc8inx 8345 19 P p NN cord-010092-uftc8inx 8345 20 ediatrique ediatrique NN cord-010092-uftc8inx 8345 21 de de FW cord-010092-uftc8inx 8345 22 KalembeLembe KalembeLembe NNP cord-010092-uftc8inx 8345 23 ( ( -LRB- cord-010092-uftc8inx 8345 24 HPKLL HPKLL NNP cord-010092-uftc8inx 8345 25 ) ) -RRB- cord-010092-uftc8inx 8345 26 ( ( -LRB- cord-010092-uftc8inx 8345 27 10 10 CD cord-010092-uftc8inx 8345 28 surfaces surface NNS cord-010092-uftc8inx 8345 29 , , , cord-010092-uftc8inx 8345 30 1 1 CD cord-010092-uftc8inx 8345 31 air air NN cord-010092-uftc8inx 8345 32 ) ) -RRB- cord-010092-uftc8inx 8345 33 , , , cord-010092-uftc8inx 8345 34 Hôpital Hôpital NNP cord-010092-uftc8inx 8345 35 Provincial Provincial NNP cord-010092-uftc8inx 8345 36 G G NNP cord-010092-uftc8inx 8345 37 en en FW cord-010092-uftc8inx 8345 38 eral eral FW cord-010092-uftc8inx 8345 39 de de FW cord-010092-uftc8inx 8345 40 R R NNP cord-010092-uftc8inx 8345 41 ef ef NN cord-010092-uftc8inx 8345 42 erence erence NN cord-010092-uftc8inx 8345 43 ( ( -LRB- cord-010092-uftc8inx 8345 44 HPGRK HPGRK NNP cord-010092-uftc8inx 8345 45 ) ) -RRB- cord-010092-uftc8inx 8346 1 ( ( -LRB- cord-010092-uftc8inx 8346 2 24 24 CD cord-010092-uftc8inx 8346 3 surfaces surface NNS cord-010092-uftc8inx 8346 4 , , , cord-010092-uftc8inx 8346 5 2 2 CD cord-010092-uftc8inx 8346 6 air air NN cord-010092-uftc8inx 8346 7 ) ) -RRB- cord-010092-uftc8inx 8346 8 and and CC cord-010092-uftc8inx 8346 9 the the DT cord-010092-uftc8inx 8346 10 National National NNP cord-010092-uftc8inx 8346 11 Blood Blood NNP cord-010092-uftc8inx 8346 12 Transfusion Transfusion NNP cord-010092-uftc8inx 8346 13 Centre Centre NNP cord-010092-uftc8inx 8346 14 ( ( -LRB- cord-010092-uftc8inx 8346 15 CNTS CNTS NNP cord-010092-uftc8inx 8346 16 ) ) -RRB- cord-010092-uftc8inx 8346 17 ( ( -LRB- cord-010092-uftc8inx 8346 18 20 20 CD cord-010092-uftc8inx 8346 19 surfaces surface NNS cord-010092-uftc8inx 8346 20 , , , cord-010092-uftc8inx 8346 21 2 2 CD cord-010092-uftc8inx 8346 22 air air NN cord-010092-uftc8inx 8346 23 ) ) -RRB- cord-010092-uftc8inx 8346 24 . . . cord-010092-uftc8inx 8347 1 Surfaces surface NNS cord-010092-uftc8inx 8347 2 that that WDT cord-010092-uftc8inx 8347 3 are be VBP cord-010092-uftc8inx 8347 4 regularly regularly RB cord-010092-uftc8inx 8347 5 in in IN cord-010092-uftc8inx 8347 6 contact contact NN cord-010092-uftc8inx 8347 7 with with IN cord-010092-uftc8inx 8347 8 blood blood NN cord-010092-uftc8inx 8347 9 products product NNS cord-010092-uftc8inx 8347 10 were be VBD cord-010092-uftc8inx 8347 11 selected select VBN cord-010092-uftc8inx 8347 12 ( ( -LRB- cord-010092-uftc8inx 8347 13 sealer sealer NN cord-010092-uftc8inx 8347 14 , , , cord-010092-uftc8inx 8347 15 fridge fridge NN cord-010092-uftc8inx 8347 16 , , , cord-010092-uftc8inx 8347 17 donor donor NN cord-010092-uftc8inx 8347 18 chair chair NN cord-010092-uftc8inx 8347 19 , , , cord-010092-uftc8inx 8347 20 . . . cord-010092-uftc8inx 8347 21 . . . cord-010092-uftc8inx 8347 22 .. .. NFP cord-010092-uftc8inx 8347 23 ) ) -RRB- cord-010092-uftc8inx 8347 24 . . . cord-010092-uftc8inx 8348 1 Regular regular JJ cord-010092-uftc8inx 8348 2 surfaces surface NNS cord-010092-uftc8inx 8348 3 were be VBD cord-010092-uftc8inx 8348 4 sampled sample VBN cord-010092-uftc8inx 8348 5 using use VBG cord-010092-uftc8inx 8348 6 RODAC RODAC NNP cord-010092-uftc8inx 8348 7 contact contact NN cord-010092-uftc8inx 8348 8 plates plate NNS cord-010092-uftc8inx 8348 9 ( ( -LRB- cord-010092-uftc8inx 8348 10 23.7 23.7 CD cord-010092-uftc8inx 8348 11 cm² cm² RBS cord-010092-uftc8inx 8348 12 ) ) -RRB- cord-010092-uftc8inx 8348 13 containing contain VBG cord-010092-uftc8inx 8348 14 CLED CLED NNP cord-010092-uftc8inx 8348 15 and and CC cord-010092-uftc8inx 8348 16 MacConkey MacConkey NNP cord-010092-uftc8inx 8348 17 agar agar NN cord-010092-uftc8inx 8348 18 , , , cord-010092-uftc8inx 8348 19 irregular irregular JJ cord-010092-uftc8inx 8348 20 surfaces surface NNS cord-010092-uftc8inx 8348 21 using use VBG cord-010092-uftc8inx 8348 22 swabs swab NNS cord-010092-uftc8inx 8348 23 ( ( -LRB- cord-010092-uftc8inx 8348 24 NRSII NRSII NNP cord-010092-uftc8inx 8348 25 , , , cord-010092-uftc8inx 8348 26 MedicalWire MedicalWire NNP cord-010092-uftc8inx 8348 27 ) ) -RRB- cord-010092-uftc8inx 8348 28 . . . cord-010092-uftc8inx 8349 1 ATP ATP NNP cord-010092-uftc8inx 8349 2 was be VBD cord-010092-uftc8inx 8349 3 measured measure VBN cord-010092-uftc8inx 8349 4 on on IN cord-010092-uftc8inx 8349 5 the the DT cord-010092-uftc8inx 8349 6 same same JJ cord-010092-uftc8inx 8349 7 surface surface NN cord-010092-uftc8inx 8349 8 ( ( -LRB- cord-010092-uftc8inx 8349 9 PD30 PD30 NNP cord-010092-uftc8inx 8349 10 , , , cord-010092-uftc8inx 8349 11 Kikkoman Kikkoman NNP cord-010092-uftc8inx 8349 12 ) ) -RRB- cord-010092-uftc8inx 8349 13 , , , cord-010092-uftc8inx 8349 14 expressed express VBN cord-010092-uftc8inx 8349 15 as as IN cord-010092-uftc8inx 8349 16 Relative Relative NNP cord-010092-uftc8inx 8349 17 Light Light NNP cord-010092-uftc8inx 8349 18 Units Units NNPS cord-010092-uftc8inx 8349 19 ( ( -LRB- cord-010092-uftc8inx 8349 20 RLU RLU NNP cord-010092-uftc8inx 8349 21 ) ) -RRB- cord-010092-uftc8inx 8349 22 per per IN cord-010092-uftc8inx 8349 23 100 100 CD cord-010092-uftc8inx 8349 24 cm² cm² NNP cord-010092-uftc8inx 8349 25 . . . cord-010092-uftc8inx 8350 1 Air air NN cord-010092-uftc8inx 8350 2 was be VBD cord-010092-uftc8inx 8350 3 sampled sample VBN cord-010092-uftc8inx 8350 4 by by IN cord-010092-uftc8inx 8350 5 active active JJ cord-010092-uftc8inx 8350 6 sampling sampling NN cord-010092-uftc8inx 8350 7 ( ( -LRB- cord-010092-uftc8inx 8350 8 500 500 CD cord-010092-uftc8inx 8350 9 liter liter NN cord-010092-uftc8inx 8350 10 ; ; : cord-010092-uftc8inx 8350 11 SpinAir SpinAir NNP cord-010092-uftc8inx 8350 12 , , , cord-010092-uftc8inx 8350 13 IUL IUL NNP cord-010092-uftc8inx 8350 14 ) ) -RRB- cord-010092-uftc8inx 8350 15 on on IN cord-010092-uftc8inx 8350 16 CLED CLED NNP cord-010092-uftc8inx 8350 17 and and CC cord-010092-uftc8inx 8350 18 MacConkey MacConkey NNP cord-010092-uftc8inx 8350 19 medium medium NN cord-010092-uftc8inx 8350 20 . . . cord-010092-uftc8inx 8351 1 In in IN cord-010092-uftc8inx 8351 2 parallel parallel NN cord-010092-uftc8inx 8351 3 , , , cord-010092-uftc8inx 8351 4 particles particle NNS cord-010092-uftc8inx 8351 5 > > XX cord-010092-uftc8inx 8351 6 0.5 0.5 CD cord-010092-uftc8inx 8351 7 lm lm NNP cord-010092-uftc8inx 8351 8 and and CC cord-010092-uftc8inx 8351 9 > > XX cord-010092-uftc8inx 8351 10 5 5 CD cord-010092-uftc8inx 8351 11 lm lm NNP cord-010092-uftc8inx 8351 12 were be VBD cord-010092-uftc8inx 8351 13 counted count VBN cord-010092-uftc8inx 8351 14 using use VBG cord-010092-uftc8inx 8351 15 a a DT cord-010092-uftc8inx 8351 16 particle particle NN cord-010092-uftc8inx 8351 17 counter counter NN cord-010092-uftc8inx 8351 18 ( ( -LRB- cord-010092-uftc8inx 8351 19 14,15 14,15 CD cord-010092-uftc8inx 8351 20 liter liter NN cord-010092-uftc8inx 8351 21 ; ; : cord-010092-uftc8inx 8351 22 MetOne MetOne NNP cord-010092-uftc8inx 8351 23 227A 227a CD cord-010092-uftc8inx 8351 24 ) ) -RRB- cord-010092-uftc8inx 8351 25 . . . cord-010092-uftc8inx 8352 1 Culture culture NN cord-010092-uftc8inx 8352 2 media medium NNS cord-010092-uftc8inx 8352 3 were be VBD cord-010092-uftc8inx 8352 4 incubated incubate VBN cord-010092-uftc8inx 8352 5 for for IN cord-010092-uftc8inx 8352 6 48 48 CD cord-010092-uftc8inx 8352 7 h h NN cord-010092-uftc8inx 8352 8 at at IN cord-010092-uftc8inx 8352 9 35 35 CD cord-010092-uftc8inx 8352 10 ° ° NN cord-010092-uftc8inx 8352 11 C c NN cord-010092-uftc8inx 8352 12 before before IN cord-010092-uftc8inx 8352 13 counting count VBG cord-010092-uftc8inx 8352 14 colony colony NN cord-010092-uftc8inx 8352 15 forming form VBG cord-010092-uftc8inx 8352 16 units unit NNS cord-010092-uftc8inx 8352 17 ( ( -LRB- cord-010092-uftc8inx 8352 18 CFU CFU NNP cord-010092-uftc8inx 8352 19 ) ) -RRB- cord-010092-uftc8inx 8352 20 . . . cord-010092-uftc8inx 8353 1 Results result NNS cord-010092-uftc8inx 8353 2 : : : cord-010092-uftc8inx 8354 1 For for IN cord-010092-uftc8inx 8354 2 regular regular JJ cord-010092-uftc8inx 8354 3 surfaces surface NNS cord-010092-uftc8inx 8354 4 , , , cord-010092-uftc8inx 8354 5 the the DT cord-010092-uftc8inx 8354 6 median median NN cord-010092-uftc8inx 8354 7 ( ( -LRB- cord-010092-uftc8inx 8354 8 range range NN cord-010092-uftc8inx 8354 9 ) ) -RRB- cord-010092-uftc8inx 8354 10 viable viable JJ cord-010092-uftc8inx 8354 11 bacterial bacterial JJ cord-010092-uftc8inx 8354 12 count count NN cord-010092-uftc8inx 8354 13 was be VBD cord-010092-uftc8inx 8354 14 27 27 CD cord-010092-uftc8inx 8354 15 ( ( -LRB- cord-010092-uftc8inx 8354 16 6 6 CD cord-010092-uftc8inx 8354 17 - - SYM cord-010092-uftc8inx 8354 18 60 60 CD cord-010092-uftc8inx 8354 19 ) ) -RRB- cord-010092-uftc8inx 8355 1 CFU CFU NNP cord-010092-uftc8inx 8355 2 / / SYM cord-010092-uftc8inx 8355 3 RODAC RODAC NNP cord-010092-uftc8inx 8355 4 , , , cord-010092-uftc8inx 8355 5 69 69 CD cord-010092-uftc8inx 8355 6 ( ( -LRB- cord-010092-uftc8inx 8355 7 6 6 CD cord-010092-uftc8inx 8355 8 - - SYM cord-010092-uftc8inx 8355 9 103 103 CD cord-010092-uftc8inx 8355 10 ) ) -RRB- cord-010092-uftc8inx 8355 11 CFU CFU NNP cord-010092-uftc8inx 8355 12 / / SYM cord-010092-uftc8inx 8355 13 RODAC RODAC NNP cord-010092-uftc8inx 8355 14 , , , cord-010092-uftc8inx 8355 15 82 82 CD cord-010092-uftc8inx 8355 16 ( ( -LRB- cord-010092-uftc8inx 8355 17 3 3 CD cord-010092-uftc8inx 8355 18 - - SYM cord-010092-uftc8inx 8355 19 132 132 CD cord-010092-uftc8inx 8355 20 ) ) -RRB- cord-010092-uftc8inx 8355 21 CFU CFU NNP cord-010092-uftc8inx 8355 22 / / SYM cord-010092-uftc8inx 8355 23 RODAC RODAC NNP cord-010092-uftc8inx 8355 24 for for IN cord-010092-uftc8inx 8355 25 HPKLL HPKLL NNP cord-010092-uftc8inx 8355 26 , , , cord-010092-uftc8inx 8355 27 CNTS CNTS NNP cord-010092-uftc8inx 8355 28 and and CC cord-010092-uftc8inx 8355 29 HPGRK HPGRK NNP cord-010092-uftc8inx 8355 30 , , , cord-010092-uftc8inx 8355 31 respectively respectively RB cord-010092-uftc8inx 8355 32 . . . cord-010092-uftc8inx 8356 1 At at IN cord-010092-uftc8inx 8356 2 HPKLL HPKLL NNP cord-010092-uftc8inx 8356 3 , , , cord-010092-uftc8inx 8356 4 highest highest RBS cord-010092-uftc8inx 8356 5 viable viable JJ cord-010092-uftc8inx 8356 6 counts count NNS cord-010092-uftc8inx 8356 7 were be VBD cord-010092-uftc8inx 8356 8 found find VBN cord-010092-uftc8inx 8356 9 in in IN cord-010092-uftc8inx 8356 10 the the DT cord-010092-uftc8inx 8356 11 sink sink NN cord-010092-uftc8inx 8356 12 ( ( -LRB- cord-010092-uftc8inx 8356 13 plain plain JJ cord-010092-uftc8inx 8356 14 growth growth NN cord-010092-uftc8inx 8356 15 ) ) -RRB- cord-010092-uftc8inx 8356 16 and and CC cord-010092-uftc8inx 8356 17 cool cool JJ cord-010092-uftc8inx 8356 18 boxes box NNS cord-010092-uftc8inx 8356 19 ( ( -LRB- cord-010092-uftc8inx 8356 20 43 43 CD cord-010092-uftc8inx 8356 21 and and CC cord-010092-uftc8inx 8356 22 60 60 CD cord-010092-uftc8inx 8356 23 CFU CFU NNP cord-010092-uftc8inx 8356 24 / / SYM cord-010092-uftc8inx 8356 25 RODAC RODAC NNP cord-010092-uftc8inx 8356 26 ) ) -RRB- cord-010092-uftc8inx 8356 27 . . . cord-010092-uftc8inx 8357 1 In in IN cord-010092-uftc8inx 8357 2 CNTS CNTS NNP cord-010092-uftc8inx 8357 3 the the DT cord-010092-uftc8inx 8357 4 blood blood NN cord-010092-uftc8inx 8357 5 processing processing NN cord-010092-uftc8inx 8357 6 bench bench NN cord-010092-uftc8inx 8357 7 , , , cord-010092-uftc8inx 8357 8 the the DT cord-010092-uftc8inx 8357 9 donor donor NN cord-010092-uftc8inx 8357 10 chair chair NN cord-010092-uftc8inx 8357 11 arm arm NN cord-010092-uftc8inx 8357 12 support support NN cord-010092-uftc8inx 8357 13 and and CC cord-010092-uftc8inx 8357 14 washing washing NN cord-010092-uftc8inx 8357 15 basin basin NN cord-010092-uftc8inx 8357 16 showed show VBD cord-010092-uftc8inx 8357 17 the the DT cord-010092-uftc8inx 8357 18 highest high JJS cord-010092-uftc8inx 8357 19 counts count NNS cord-010092-uftc8inx 8357 20 ( ( -LRB- cord-010092-uftc8inx 8357 21 plain plain JJ cord-010092-uftc8inx 8357 22 growth growth NN cord-010092-uftc8inx 8357 23 ) ) -RRB- cord-010092-uftc8inx 8357 24 . . . cord-010092-uftc8inx 8358 1 Whereas whereas IN cord-010092-uftc8inx 8358 2 in in IN cord-010092-uftc8inx 8358 3 HPGRK HPGRK NNP cord-010092-uftc8inx 8358 4 , , , cord-010092-uftc8inx 8358 5 most most JJS cord-010092-uftc8inx 8358 6 bacteria bacteria NNS cord-010092-uftc8inx 8358 7 were be VBD cord-010092-uftc8inx 8358 8 found find VBN cord-010092-uftc8inx 8358 9 in in IN cord-010092-uftc8inx 8358 10 a a DT cord-010092-uftc8inx 8358 11 fridge fridge NN cord-010092-uftc8inx 8358 12 ( ( -LRB- cord-010092-uftc8inx 8358 13 plain plain JJ cord-010092-uftc8inx 8358 14 growth growth NN cord-010092-uftc8inx 8358 15 ) ) -RRB- cord-010092-uftc8inx 8358 16 , , , cord-010092-uftc8inx 8358 17 blood blood NN cord-010092-uftc8inx 8358 18 bag bag NN cord-010092-uftc8inx 8358 19 trolley trolley NN cord-010092-uftc8inx 8358 20 ( ( -LRB- cord-010092-uftc8inx 8358 21 plain plain JJ cord-010092-uftc8inx 8358 22 growth growth NN cord-010092-uftc8inx 8358 23 ) ) -RRB- cord-010092-uftc8inx 8358 24 and and CC cord-010092-uftc8inx 8358 25 manual manual JJ cord-010092-uftc8inx 8358 26 separator separator NN cord-010092-uftc8inx 8358 27 ( ( -LRB- cord-010092-uftc8inx 8358 28 132 132 CD cord-010092-uftc8inx 8358 29 CFU/ cfu/ NN cord-010092-uftc8inx 8358 30 RODAC RODAC NNS cord-010092-uftc8inx 8358 31 ) ) -RRB- cord-010092-uftc8inx 8358 32 . . . cord-010092-uftc8inx 8359 1 Gram gram NN cord-010092-uftc8inx 8359 2 - - HYPH cord-010092-uftc8inx 8359 3 negative negative JJ cord-010092-uftc8inx 8359 4 bacilli bacilli NN cord-010092-uftc8inx 8359 5 were be VBD cord-010092-uftc8inx 8359 6 isolated isolate VBN cord-010092-uftc8inx 8359 7 from from IN cord-010092-uftc8inx 8359 8 water water NN cord-010092-uftc8inx 8359 9 basins basin NNS cord-010092-uftc8inx 8359 10 and and CC cord-010092-uftc8inx 8359 11 sink sink VB cord-010092-uftc8inx 8359 12 in in IN cord-010092-uftc8inx 8359 13 CNTS CNTS NNP cord-010092-uftc8inx 8359 14 and and CC cord-010092-uftc8inx 8359 15 HPKLL HPKLL NNP cord-010092-uftc8inx 8359 16 , , , cord-010092-uftc8inx 8359 17 but but CC cord-010092-uftc8inx 8359 18 also also RB cord-010092-uftc8inx 8359 19 surfaces surface VBZ cord-010092-uftc8inx 8359 20 close close RB cord-010092-uftc8inx 8359 21 to to IN cord-010092-uftc8inx 8359 22 donor donor NN cord-010092-uftc8inx 8359 23 chairs chair NNS cord-010092-uftc8inx 8359 24 at at IN cord-010092-uftc8inx 8359 25 HPGRK HPGRK NNP cord-010092-uftc8inx 8359 26 . . . cord-010092-uftc8inx 8360 1 The the DT cord-010092-uftc8inx 8360 2 median median NN cord-010092-uftc8inx 8360 3 ( ( -LRB- cord-010092-uftc8inx 8360 4 range range NN cord-010092-uftc8inx 8360 5 ) ) -RRB- cord-010092-uftc8inx 8360 6 of of IN cord-010092-uftc8inx 8360 7 ATP ATP NNP cord-010092-uftc8inx 8360 8 per per IN cord-010092-uftc8inx 8360 9 100 100 CD cord-010092-uftc8inx 8360 10 cm² cm² NNPS cord-010092-uftc8inx 8360 11 was be VBD cord-010092-uftc8inx 8360 12 2.906 2.906 CD cord-010092-uftc8inx 8360 13 ( ( -LRB- cord-010092-uftc8inx 8360 14 778 778 CD cord-010092-uftc8inx 8360 15 - - HYPH cord-010092-uftc8inx 8360 16 26.497 26.497 CD cord-010092-uftc8inx 8360 17 ) ) -RRB- cord-010092-uftc8inx 8360 18 RLU rlu NN cord-010092-uftc8inx 8360 19 at at IN cord-010092-uftc8inx 8360 20 HPKLL HPKLL NNP cord-010092-uftc8inx 8360 21 , , , cord-010092-uftc8inx 8360 22 ) ) -RRB- cord-010092-uftc8inx 8360 23 RLU rlu NN cord-010092-uftc8inx 8360 24 at at IN cord-010092-uftc8inx 8360 25 CNTS CNTS NNP cord-010092-uftc8inx 8360 26 and and CC cord-010092-uftc8inx 8360 27 35.235 35.235 CD cord-010092-uftc8inx 8361 1 ( ( -LRB- cord-010092-uftc8inx 8361 2 1.754 1.754 CD cord-010092-uftc8inx 8361 3 - - SYM cord-010092-uftc8inx 8361 4 348 348 CD cord-010092-uftc8inx 8361 5 .052 .052 CD cord-010092-uftc8inx 8361 6 ) ) -RRB- cord-010092-uftc8inx 8361 7 at at IN cord-010092-uftc8inx 8361 8 HPGRK HPGRK NNP cord-010092-uftc8inx 8361 9 . . . cord-010092-uftc8inx 8362 1 ATP ATP NNP cord-010092-uftc8inx 8362 2 results result NNS cord-010092-uftc8inx 8362 3 and and CC cord-010092-uftc8inx 8362 4 total total JJ cord-010092-uftc8inx 8362 5 viable viable JJ cord-010092-uftc8inx 8362 6 count count NN cord-010092-uftc8inx 8362 7 were be VBD cord-010092-uftc8inx 8362 8 not not RB cord-010092-uftc8inx 8362 9 correlated correlate VBN cord-010092-uftc8inx 8362 10 ( ( -LRB- cord-010092-uftc8inx 8362 11 n n NN cord-010092-uftc8inx 8362 12 = = SYM cord-010092-uftc8inx 8362 13 49 49 CD cord-010092-uftc8inx 8362 14 , , , cord-010092-uftc8inx 8362 15 P p NN cord-010092-uftc8inx 8362 16 = = SYM cord-010092-uftc8inx 8362 17 0.52 0.52 CD cord-010092-uftc8inx 8362 18 ) ) -RRB- cord-010092-uftc8inx 8362 19 . . . cord-010092-uftc8inx 8363 1 Median median JJ cord-010092-uftc8inx 8363 2 ( ( -LRB- cord-010092-uftc8inx 8363 3 range range NN cord-010092-uftc8inx 8363 4 ) ) -RRB- cord-010092-uftc8inx 8363 5 bacterial bacterial JJ cord-010092-uftc8inx 8363 6 count count NN cord-010092-uftc8inx 8363 7 in in IN cord-010092-uftc8inx 8363 8 the the DT cord-010092-uftc8inx 8363 9 air air NN cord-010092-uftc8inx 8363 10 was be VBD cord-010092-uftc8inx 8363 11 258 258 CD cord-010092-uftc8inx 8363 12 ( ( -LRB- cord-010092-uftc8inx 8363 13 210 210 CD cord-010092-uftc8inx 8363 14 - - SYM cord-010092-uftc8inx 8363 15 375 375 CD cord-010092-uftc8inx 8363 16 ) ) -RRB- cord-010092-uftc8inx 8363 17 CFU/500L CFU/500L NNS cord-010092-uftc8inx 8363 18 for for IN cord-010092-uftc8inx 8363 19 all all DT cord-010092-uftc8inx 8363 20 sites site NNS cord-010092-uftc8inx 8363 21 together together RB cord-010092-uftc8inx 8363 22 . . . cord-010092-uftc8inx 8364 1 There there EX cord-010092-uftc8inx 8364 2 was be VBD cord-010092-uftc8inx 8364 3 no no DT cord-010092-uftc8inx 8364 4 correlation correlation NN cord-010092-uftc8inx 8364 5 found find VBN cord-010092-uftc8inx 8364 6 between between IN cord-010092-uftc8inx 8364 7 total total JJ cord-010092-uftc8inx 8364 8 bacterial bacterial JJ cord-010092-uftc8inx 8364 9 count count NN cord-010092-uftc8inx 8364 10 and and CC cord-010092-uftc8inx 8364 11 particles particle NNS cord-010092-uftc8inx 8364 12 > > XX cord-010092-uftc8inx 8365 1 0.5 0.5 CD cord-010092-uftc8inx 8365 2 lm lm NNP cord-010092-uftc8inx 8365 3 or or CC cord-010092-uftc8inx 8365 4 > > XX cord-010092-uftc8inx 8365 5 5 5 CD cord-010092-uftc8inx 8365 6 lm lm NNP cord-010092-uftc8inx 8366 1 ( ( -LRB- cord-010092-uftc8inx 8366 2 r r NN cord-010092-uftc8inx 8366 3 = = SYM cord-010092-uftc8inx 8366 4 0.7 0.7 CD cord-010092-uftc8inx 8366 5 and and CC cord-010092-uftc8inx 8367 1 r r LS cord-010092-uftc8inx 8367 2 = = SYM cord-010092-uftc8inx 8367 3 0.6 0.6 CD cord-010092-uftc8inx 8367 4 respectively respectively RB cord-010092-uftc8inx 8367 5 ; ; : cord-010092-uftc8inx 8367 6 P p NN cord-010092-uftc8inx 8367 7 < < XX cord-010092-uftc8inx 8367 8 0.05 0.05 CD cord-010092-uftc8inx 8367 9 ; ; : cord-010092-uftc8inx 8367 10 n n NN cord-010092-uftc8inx 8367 11 = = SYM cord-010092-uftc8inx 8367 12 5 5 CD cord-010092-uftc8inx 8367 13 ) ) -RRB- cord-010092-uftc8inx 8368 1 Summary Summary NNP cord-010092-uftc8inx 8368 2 / / SYM cord-010092-uftc8inx 8368 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 8368 4 : : : cord-010092-uftc8inx 8369 1 Total total JJ cord-010092-uftc8inx 8369 2 viable viable JJ cord-010092-uftc8inx 8369 3 bacterial bacterial JJ cord-010092-uftc8inx 8369 4 count count NN cord-010092-uftc8inx 8369 5 of of IN cord-010092-uftc8inx 8369 6 surfaces surface NNS cord-010092-uftc8inx 8369 7 varies vary VBZ cord-010092-uftc8inx 8369 8 over over IN cord-010092-uftc8inx 8369 9 blood blood NN cord-010092-uftc8inx 8369 10 bank bank NN cord-010092-uftc8inx 8369 11 sites site NNS cord-010092-uftc8inx 8369 12 . . . cord-010092-uftc8inx 8370 1 According accord VBG cord-010092-uftc8inx 8370 2 to to IN cord-010092-uftc8inx 8370 3 our -PRON- PRP$ cord-010092-uftc8inx 8370 4 results result NNS cord-010092-uftc8inx 8370 5 , , , cord-010092-uftc8inx 8370 6 ATP ATP NNP cord-010092-uftc8inx 8370 7 and and CC cord-010092-uftc8inx 8370 8 particle particle NN cord-010092-uftc8inx 8370 9 counts count NNS cord-010092-uftc8inx 8370 10 did do VBD cord-010092-uftc8inx 8370 11 not not RB cord-010092-uftc8inx 8370 12 correlate correlate VB cord-010092-uftc8inx 8370 13 with with IN cord-010092-uftc8inx 8370 14 bacterial bacterial JJ cord-010092-uftc8inx 8370 15 counts count NNS cord-010092-uftc8inx 8370 16 on on IN cord-010092-uftc8inx 8370 17 surfaces surface NNS cord-010092-uftc8inx 8370 18 and and CC cord-010092-uftc8inx 8370 19 in in IN cord-010092-uftc8inx 8370 20 the the DT cord-010092-uftc8inx 8370 21 air air NN cord-010092-uftc8inx 8370 22 , , , cord-010092-uftc8inx 8370 23 respectively respectively RB cord-010092-uftc8inx 8370 24 . . . cord-010092-uftc8inx 8371 1 Bacterial bacterial JJ cord-010092-uftc8inx 8371 2 isolates isolate NNS cord-010092-uftc8inx 8371 3 from from IN cord-010092-uftc8inx 8371 4 blood blood NN cord-010092-uftc8inx 8371 5 bank bank NN cord-010092-uftc8inx 8371 6 environments environment NNS cord-010092-uftc8inx 8371 7 in in IN cord-010092-uftc8inx 8371 8 DRC DRC NNP cord-010092-uftc8inx 8371 9 need need VBP cord-010092-uftc8inx 8371 10 to to TO cord-010092-uftc8inx 8371 11 be be VB cord-010092-uftc8inx 8371 12 identified identify VBN cord-010092-uftc8inx 8371 13 and and CC cord-010092-uftc8inx 8371 14 seasonal seasonal JJ cord-010092-uftc8inx 8371 15 variations variation NNS cord-010092-uftc8inx 8371 16 need need VBP cord-010092-uftc8inx 8371 17 to to TO cord-010092-uftc8inx 8371 18 be be VB cord-010092-uftc8inx 8371 19 evaluated evaluate VBN cord-010092-uftc8inx 8371 20 . . . cord-010092-uftc8inx 8372 1 Background background NN cord-010092-uftc8inx 8372 2 : : : cord-010092-uftc8inx 8373 1 The the DT cord-010092-uftc8inx 8373 2 risk risk NN cord-010092-uftc8inx 8373 3 of of IN cord-010092-uftc8inx 8373 4 transfusion transfusion NN cord-010092-uftc8inx 8373 5 - - HYPH cord-010092-uftc8inx 8373 6 transmitted transmit VBN cord-010092-uftc8inx 8373 7 hepatitis hepatitis NN cord-010092-uftc8inx 8373 8 E e NN cord-010092-uftc8inx 8373 9 virus virus NN cord-010092-uftc8inx 8373 10 ( ( -LRB- cord-010092-uftc8inx 8373 11 TT TT NNP cord-010092-uftc8inx 8373 12 - - HYPH cord-010092-uftc8inx 8373 13 HEV HEV NNP cord-010092-uftc8inx 8373 14 ) ) -RRB- cord-010092-uftc8inx 8373 15 infections infection NNS cord-010092-uftc8inx 8373 16 in in IN cord-010092-uftc8inx 8373 17 line line NN cord-010092-uftc8inx 8373 18 with with IN cord-010092-uftc8inx 8373 19 the the DT cord-010092-uftc8inx 8373 20 question question NN cord-010092-uftc8inx 8373 21 of of IN cord-010092-uftc8inx 8373 22 the the DT cord-010092-uftc8inx 8373 23 necessity necessity NN cord-010092-uftc8inx 8373 24 of of IN cord-010092-uftc8inx 8373 25 HEV HEV NNP cord-010092-uftc8inx 8373 26 - - HYPH cord-010092-uftc8inx 8373 27 NAT NAT NNP cord-010092-uftc8inx 8373 28 screening screening NN cord-010092-uftc8inx 8373 29 of of IN cord-010092-uftc8inx 8373 30 blood blood NN cord-010092-uftc8inx 8373 31 products product NNS cord-010092-uftc8inx 8373 32 is be VBZ cord-010092-uftc8inx 8373 33 currently currently RB cord-010092-uftc8inx 8373 34 subject subject JJ cord-010092-uftc8inx 8373 35 to to IN cord-010092-uftc8inx 8373 36 an an DT cord-010092-uftc8inx 8373 37 ongoing ongoing JJ cord-010092-uftc8inx 8373 38 debate debate NN cord-010092-uftc8inx 8373 39 on on IN cord-010092-uftc8inx 8373 40 the the DT cord-010092-uftc8inx 8373 41 importance importance NN cord-010092-uftc8inx 8373 42 of of IN cord-010092-uftc8inx 8373 43 timely timely JJ cord-010092-uftc8inx 8373 44 introduction introduction NN cord-010092-uftc8inx 8373 45 of of IN cord-010092-uftc8inx 8373 46 HEV HEV NNP cord-010092-uftc8inx 8373 47 screening screening NN cord-010092-uftc8inx 8373 48 of of IN cord-010092-uftc8inx 8373 49 blood blood NN cord-010092-uftc8inx 8373 50 donors donor NNS cord-010092-uftc8inx 8373 51 and and CC cord-010092-uftc8inx 8373 52 the the DT cord-010092-uftc8inx 8373 53 impact impact NN cord-010092-uftc8inx 8373 54 of of IN cord-010092-uftc8inx 8373 55 blood blood NN cord-010092-uftc8inx 8373 56 safety safety NN cord-010092-uftc8inx 8373 57 . . . cord-010092-uftc8inx 8374 1 Different different JJ cord-010092-uftc8inx 8374 2 countries country NNS cord-010092-uftc8inx 8374 3 have have VBP cord-010092-uftc8inx 8374 4 chosen choose VBN cord-010092-uftc8inx 8374 5 different different JJ cord-010092-uftc8inx 8374 6 regulatory regulatory JJ cord-010092-uftc8inx 8374 7 approaches approach NNS cord-010092-uftc8inx 8374 8 . . . cord-010092-uftc8inx 8375 1 Just just RB cord-010092-uftc8inx 8375 2 recently recently RB cord-010092-uftc8inx 8375 3 , , , cord-010092-uftc8inx 8375 4 the the DT cord-010092-uftc8inx 8375 5 German german JJ cord-010092-uftc8inx 8375 6 federal federal JJ cord-010092-uftc8inx 8375 7 authorities authority NNS cord-010092-uftc8inx 8375 8 have have VBP cord-010092-uftc8inx 8375 9 introduced introduce VBN cord-010092-uftc8inx 8375 10 mandatory mandatory JJ cord-010092-uftc8inx 8375 11 testing testing NN cord-010092-uftc8inx 8375 12 of of IN cord-010092-uftc8inx 8375 13 all all DT cord-010092-uftc8inx 8375 14 therapeutic therapeutic JJ cord-010092-uftc8inx 8375 15 blood blood NN cord-010092-uftc8inx 8375 16 products product NNS cord-010092-uftc8inx 8375 17 beginning begin VBG cord-010092-uftc8inx 8375 18 from from IN cord-010092-uftc8inx 8375 19 January January NNP cord-010092-uftc8inx 8375 20 1st 1st NN cord-010092-uftc8inx 8375 21 2020 2020 CD cord-010092-uftc8inx 8375 22 . . . cord-010092-uftc8inx 8376 1 However however RB cord-010092-uftc8inx 8376 2 , , , cord-010092-uftc8inx 8376 3 we -PRON- PRP cord-010092-uftc8inx 8376 4 already already RB cord-010092-uftc8inx 8376 5 decided decide VBD cord-010092-uftc8inx 8376 6 to to TO cord-010092-uftc8inx 8376 7 voluntarily voluntarily RB cord-010092-uftc8inx 8376 8 test test VB cord-010092-uftc8inx 8376 9 all all PDT cord-010092-uftc8inx 8376 10 our -PRON- PRP$ cord-010092-uftc8inx 8376 11 blood blood NN cord-010092-uftc8inx 8376 12 products product NNS cord-010092-uftc8inx 8376 13 since since IN cord-010092-uftc8inx 8376 14 January January NNP cord-010092-uftc8inx 8376 15 2015 2015 CD cord-010092-uftc8inx 8376 16 . . . cord-010092-uftc8inx 8377 1 Aims aim VBZ cord-010092-uftc8inx 8377 2 : : : cord-010092-uftc8inx 8378 1 In in IN cord-010092-uftc8inx 8378 2 this this DT cord-010092-uftc8inx 8378 3 study study NN cord-010092-uftc8inx 8378 4 , , , cord-010092-uftc8inx 8378 5 we -PRON- PRP cord-010092-uftc8inx 8378 6 present present VBP cord-010092-uftc8inx 8378 7 our -PRON- PRP$ cord-010092-uftc8inx 8378 8 results result NNS cord-010092-uftc8inx 8378 9 of of IN cord-010092-uftc8inx 8378 10 a a DT cord-010092-uftc8inx 8378 11 100 100 CD cord-010092-uftc8inx 8378 12 % % NN cord-010092-uftc8inx 8378 13 screening screening NN cord-010092-uftc8inx 8378 14 of of IN cord-010092-uftc8inx 8378 15 therapeutic therapeutic JJ cord-010092-uftc8inx 8378 16 blood blood NN cord-010092-uftc8inx 8378 17 products product NNS cord-010092-uftc8inx 8378 18 for for IN cord-010092-uftc8inx 8378 19 HEV HEV NNP cord-010092-uftc8inx 8378 20 RNA RNA NNP cord-010092-uftc8inx 8378 21 including include VBG cord-010092-uftc8inx 8378 22 four four CD cord-010092-uftc8inx 8378 23 years year NNS cord-010092-uftc8inx 8378 24 of of IN cord-010092-uftc8inx 8378 25 active active JJ cord-010092-uftc8inx 8378 26 surveillance surveillance NN cord-010092-uftc8inx 8378 27 of of IN cord-010092-uftc8inx 8378 28 hepatitis hepatitis NN cord-010092-uftc8inx 8378 29 E e NN cord-010092-uftc8inx 8378 30 infection infection NN cord-010092-uftc8inx 8378 31 among among IN cord-010092-uftc8inx 8378 32 blood blood NN cord-010092-uftc8inx 8378 33 donors donor NNS cord-010092-uftc8inx 8378 34 in in IN cord-010092-uftc8inx 8378 35 Germany Germany NNP cord-010092-uftc8inx 8378 36 . . . cord-010092-uftc8inx 8379 1 Methods method NNS cord-010092-uftc8inx 8379 2 : : : cord-010092-uftc8inx 8380 1 From from IN cord-010092-uftc8inx 8380 2 January January NNP cord-010092-uftc8inx 8380 3 2015 2015 CD cord-010092-uftc8inx 8380 4 to to IN cord-010092-uftc8inx 8380 5 December December NNP cord-010092-uftc8inx 8380 6 2018 2018 CD cord-010092-uftc8inx 8380 7 , , , cord-010092-uftc8inx 8380 8 a a DT cord-010092-uftc8inx 8380 9 total total NN cord-010092-uftc8inx 8380 10 of of IN cord-010092-uftc8inx 8380 11 386,307 386,307 CD cord-010092-uftc8inx 8380 12 allogenic allogenic JJ cord-010092-uftc8inx 8380 13 blood blood NN cord-010092-uftc8inx 8380 14 donations donation NNS cord-010092-uftc8inx 8380 15 from from IN cord-010092-uftc8inx 8380 16 69,956 69,956 CD cord-010092-uftc8inx 8380 17 individual individual JJ cord-010092-uftc8inx 8380 18 German german JJ cord-010092-uftc8inx 8380 19 blood blood NN cord-010092-uftc8inx 8380 20 donors donor NNS cord-010092-uftc8inx 8380 21 were be VBD cord-010092-uftc8inx 8380 22 screened screen VBN cord-010092-uftc8inx 8380 23 in in IN cord-010092-uftc8inx 8380 24 a a DT cord-010092-uftc8inx 8380 25 minipool minipool NN cord-010092-uftc8inx 8380 26 format format NN cord-010092-uftc8inx 8380 27 of of IN cord-010092-uftc8inx 8380 28 96 96 CD cord-010092-uftc8inx 8380 29 samples sample NNS cord-010092-uftc8inx 8380 30 of of IN cord-010092-uftc8inx 8380 31 for for IN cord-010092-uftc8inx 8380 32 the the DT cord-010092-uftc8inx 8380 33 presence presence NN cord-010092-uftc8inx 8380 34 of of IN cord-010092-uftc8inx 8380 35 HEV HEV NNP cord-010092-uftc8inx 8380 36 RNA RNA NNP cord-010092-uftc8inx 8380 37 ( ( -LRB- cord-010092-uftc8inx 8380 38 RealStar RealStar NNP cord-010092-uftc8inx 8380 39 HEV HEV NNP cord-010092-uftc8inx 8380 40 RT RT NNP cord-010092-uftc8inx 8380 41 - - HYPH cord-010092-uftc8inx 8380 42 PCR PCR NNP cord-010092-uftc8inx 8380 43 Kit kit NN cord-010092-uftc8inx 8380 44 , , , cord-010092-uftc8inx 8380 45 Altona Altona NNP cord-010092-uftc8inx 8380 46 Diagnostic Diagnostic NNP cord-010092-uftc8inx 8380 47 Technologies Technologies NNP cord-010092-uftc8inx 8380 48 ( ( -LRB- cord-010092-uftc8inx 8380 49 ADT ADT NNP cord-010092-uftc8inx 8380 50 ) ) -RRB- cord-010092-uftc8inx 8380 51 , , , cord-010092-uftc8inx 8380 52 Hamburg Hamburg NNP cord-010092-uftc8inx 8380 53 , , , cord-010092-uftc8inx 8380 54 Germany Germany NNP cord-010092-uftc8inx 8380 55 ) ) -RRB- cord-010092-uftc8inx 8380 56 . . . cord-010092-uftc8inx 8381 1 Nucleic nucleic JJ cord-010092-uftc8inx 8381 2 acids acid NNS cord-010092-uftc8inx 8381 3 were be VBD cord-010092-uftc8inx 8381 4 extracted extract VBN cord-010092-uftc8inx 8381 5 from from IN cord-010092-uftc8inx 8381 6 4.8 4.8 CD cord-010092-uftc8inx 8381 7 ml ml NN cord-010092-uftc8inx 8381 8 plasma plasma NN cord-010092-uftc8inx 8381 9 using use VBG cord-010092-uftc8inx 8381 10 the the DT cord-010092-uftc8inx 8381 11 Chemagen Chemagen NNP cord-010092-uftc8inx 8381 12 MSM MSM NNP cord-010092-uftc8inx 8381 13 - - HYPH cord-010092-uftc8inx 8381 14 I i NN cord-010092-uftc8inx 8381 15 extractor extractor NN cord-010092-uftc8inx 8381 16 ( ( -LRB- cord-010092-uftc8inx 8381 17 Viral Viral NNP cord-010092-uftc8inx 8381 18 5k 5k CD cord-010092-uftc8inx 8381 19 , , , cord-010092-uftc8inx 8381 20 Perkin Perkin NNP cord-010092-uftc8inx 8381 21 Elmer Elmer NNP cord-010092-uftc8inx 8381 22 Chemagen Chemagen NNP cord-010092-uftc8inx 8381 23 GmbH GmbH NNP cord-010092-uftc8inx 8381 24 ) ) -RRB- cord-010092-uftc8inx 8381 25 . . . cord-010092-uftc8inx 8382 1 The the DT cord-010092-uftc8inx 8382 2 95 95 CD cord-010092-uftc8inx 8382 3 % % NN cord-010092-uftc8inx 8382 4 LOD lod NN cord-010092-uftc8inx 8382 5 of of IN cord-010092-uftc8inx 8382 6 the the DT cord-010092-uftc8inx 8382 7 assay assay NN cord-010092-uftc8inx 8382 8 was be VBD cord-010092-uftc8inx 8382 9 determined determine VBN cord-010092-uftc8inx 8382 10 to to IN cord-010092-uftc8inx 8382 11 4.66 4.66 CD cord-010092-uftc8inx 8382 12 IU IU NNP cord-010092-uftc8inx 8382 13 / / SYM cord-010092-uftc8inx 8382 14 ml ml NN cord-010092-uftc8inx 8382 15 ( ( -LRB- cord-010092-uftc8inx 8382 16 447 447 CD cord-010092-uftc8inx 8382 17 IU IU NNP cord-010092-uftc8inx 8382 18 / / , cord-010092-uftc8inx 8382 19 ml ml NN cord-010092-uftc8inx 8382 20 per per IN cord-010092-uftc8inx 8382 21 single single JJ cord-010092-uftc8inx 8382 22 donation donation NN cord-010092-uftc8inx 8382 23 ) ) -RRB- cord-010092-uftc8inx 8382 24 . . . cord-010092-uftc8inx 8383 1 The the DT cord-010092-uftc8inx 8383 2 presence presence NN cord-010092-uftc8inx 8383 3 of of IN cord-010092-uftc8inx 8383 4 HEV hev NN cord-010092-uftc8inx 8383 5 - - HYPH cord-010092-uftc8inx 8383 6 specific specific JJ cord-010092-uftc8inx 8383 7 IgM IgM NNP cord-010092-uftc8inx 8383 8 and and CC cord-010092-uftc8inx 8383 9 IgG IgG NNP cord-010092-uftc8inx 8383 10 antibodies antibody NNS cord-010092-uftc8inx 8383 11 was be VBD cord-010092-uftc8inx 8383 12 determined determine VBN cord-010092-uftc8inx 8383 13 using use VBG cord-010092-uftc8inx 8383 14 the the DT cord-010092-uftc8inx 8383 15 anti anti JJ cord-010092-uftc8inx 8383 16 - - JJ cord-010092-uftc8inx 8383 17 HEV HEV NNP cord-010092-uftc8inx 8383 18 IgM IgM NNP cord-010092-uftc8inx 8383 19 / / SYM cord-010092-uftc8inx 8383 20 IgG IgG NNP cord-010092-uftc8inx 8383 21 ELISA ELISA NNP cord-010092-uftc8inx 8383 22 ( ( -LRB- cord-010092-uftc8inx 8383 23 Euroimmun Euroimmun NNP cord-010092-uftc8inx 8383 24 , , , cord-010092-uftc8inx 8383 25 Luebeck Luebeck NNP cord-010092-uftc8inx 8383 26 ) ) -RRB- cord-010092-uftc8inx 8383 27 . . . cord-010092-uftc8inx 8384 1 HEV HEV NNP cord-010092-uftc8inx 8384 2 RNA RNA NNP cord-010092-uftc8inx 8384 3 concentrations concentration NNS cord-010092-uftc8inx 8384 4 were be VBD cord-010092-uftc8inx 8384 5 quantified quantify VBN cord-010092-uftc8inx 8384 6 using use VBG cord-010092-uftc8inx 8384 7 the the DT cord-010092-uftc8inx 8384 8 first first JJ cord-010092-uftc8inx 8384 9 WHO WHO NNP cord-010092-uftc8inx 8384 10 international international JJ cord-010092-uftc8inx 8384 11 Standard Standard NNP cord-010092-uftc8inx 8384 12 for for IN cord-010092-uftc8inx 8384 13 hepatitis hepatitis NN cord-010092-uftc8inx 8384 14 E E NNP cord-010092-uftc8inx 8384 15 Virus Virus NNP cord-010092-uftc8inx 8384 16 RNA RNA NNP cord-010092-uftc8inx 8384 17 for for IN cord-010092-uftc8inx 8384 18 NAT NAT NNP cord-010092-uftc8inx 8384 19 - - HYPH cord-010092-uftc8inx 8384 20 based base VBN cord-010092-uftc8inx 8384 21 assays assay NNS cord-010092-uftc8inx 8384 22 . . . cord-010092-uftc8inx 8385 1 All all DT cord-010092-uftc8inx 8385 2 HEV HEV NNP cord-010092-uftc8inx 8385 3 RNA RNA NNP cord-010092-uftc8inx 8385 4 positive positive JJ cord-010092-uftc8inx 8385 5 donors donor NNS cord-010092-uftc8inx 8385 6 were be VBD cord-010092-uftc8inx 8385 7 deferred defer VBN cord-010092-uftc8inx 8385 8 from from IN cord-010092-uftc8inx 8385 9 donation donation NN cord-010092-uftc8inx 8385 10 for for IN cord-010092-uftc8inx 8385 11 3 3 CD cord-010092-uftc8inx 8385 12 months month NNS cord-010092-uftc8inx 8385 13 . . . cord-010092-uftc8inx 8386 1 Follow follow VB cord-010092-uftc8inx 8386 2 - - HYPH cord-010092-uftc8inx 8386 3 up up NN cord-010092-uftc8inx 8386 4 samples sample NNS cord-010092-uftc8inx 8386 5 were be VBD cord-010092-uftc8inx 8386 6 tested test VBN cord-010092-uftc8inx 8386 7 for for IN cord-010092-uftc8inx 8386 8 the the DT cord-010092-uftc8inx 8386 9 presence presence NN cord-010092-uftc8inx 8386 10 of of IN cord-010092-uftc8inx 8386 11 HEV HEV NNP cord-010092-uftc8inx 8386 12 RNA RNA NNP cord-010092-uftc8inx 8386 13 and and CC cord-010092-uftc8inx 8386 14 HEV hev NN cord-010092-uftc8inx 8386 15 - - HYPH cord-010092-uftc8inx 8386 16 specific specific JJ cord-010092-uftc8inx 8386 17 antibodies antibody NNS cord-010092-uftc8inx 8386 18 . . . cord-010092-uftc8inx 8387 1 Genotyping Genotyping NNP cord-010092-uftc8inx 8387 2 was be VBD cord-010092-uftc8inx 8387 3 performed perform VBN cord-010092-uftc8inx 8387 4 by by IN cord-010092-uftc8inx 8387 5 sequencing sequence VBG cord-010092-uftc8inx 8387 6 of of IN cord-010092-uftc8inx 8387 7 the the DT cord-010092-uftc8inx 8387 8 hypervariable hypervariable JJ cord-010092-uftc8inx 8387 9 region region NN cord-010092-uftc8inx 8387 10 ( ( -LRB- cord-010092-uftc8inx 8387 11 HVR HVR NNP cord-010092-uftc8inx 8387 12 ) ) -RRB- cord-010092-uftc8inx 8387 13 and and CC cord-010092-uftc8inx 8387 14 ORF1 ORF1 NNP cord-010092-uftc8inx 8387 15 . . . cord-010092-uftc8inx 8388 1 Results result NNS cord-010092-uftc8inx 8388 2 : : : cord-010092-uftc8inx 8389 1 In in IN cord-010092-uftc8inx 8389 2 total total JJ cord-010092-uftc8inx 8389 3 , , , cord-010092-uftc8inx 8389 4 274 274 CD cord-010092-uftc8inx 8389 5 HEV HEV NNP cord-010092-uftc8inx 8389 6 RNA RNA NNP cord-010092-uftc8inx 8389 7 positive positive JJ cord-010092-uftc8inx 8389 8 donors donor NNS cord-010092-uftc8inx 8389 9 were be VBD cord-010092-uftc8inx 8389 10 identified identify VBN cord-010092-uftc8inx 8389 11 . . . cord-010092-uftc8inx 8390 1 Of of IN cord-010092-uftc8inx 8390 2 these these DT cord-010092-uftc8inx 8390 3 , , , cord-010092-uftc8inx 8390 4 274 274 CD cord-010092-uftc8inx 8390 5 HEV HEV NNP cord-010092-uftc8inx 8390 6 RNA RNA NNP cord-010092-uftc8inx 8390 7 - - HYPH cord-010092-uftc8inx 8390 8 positive positive JJ cord-010092-uftc8inx 8390 9 donors donor NNS cord-010092-uftc8inx 8390 10 , , , cord-010092-uftc8inx 8390 11 216 216 CD cord-010092-uftc8inx 8390 12 were be VBD cord-010092-uftc8inx 8390 13 NAT NAT NNP cord-010092-uftc8inx 8390 14 - - HYPH cord-010092-uftc8inx 8390 15 only only JJ cord-010092-uftc8inx 8390 16 positive positive JJ cord-010092-uftc8inx 8390 17 donations donation NNS cord-010092-uftc8inx 8390 18 ( ( -LRB- cord-010092-uftc8inx 8390 19 78.83 78.83 CD cord-010092-uftc8inx 8390 20 % % NN cord-010092-uftc8inx 8390 21 , , , cord-010092-uftc8inx 8390 22 negative negative JJ cord-010092-uftc8inx 8390 23 for for IN cord-010092-uftc8inx 8390 24 anti anti JJ cord-010092-uftc8inx 8390 25 - - JJ cord-010092-uftc8inx 8390 26 HEV hev JJ cord-010092-uftc8inx 8390 27 IgM IgM NNP cord-010092-uftc8inx 8390 28 and and CC cord-010092-uftc8inx 8390 29 anti anti JJ cord-010092-uftc8inx 8390 30 - - JJ cord-010092-uftc8inx 8390 31 HEV hev JJ cord-010092-uftc8inx 8390 32 IgG igg NN cord-010092-uftc8inx 8390 33 ) ) -RRB- cord-010092-uftc8inx 8390 34 , , , cord-010092-uftc8inx 8390 35 three three CD cord-010092-uftc8inx 8390 36 donors donor NNS cord-010092-uftc8inx 8390 37 had have VBD cord-010092-uftc8inx 8390 38 a a DT cord-010092-uftc8inx 8390 39 positive positive JJ cord-010092-uftc8inx 8390 40 IgM IgM NNP cord-010092-uftc8inx 8390 41 titer titer NN cord-010092-uftc8inx 8390 42 ( ( -LRB- cord-010092-uftc8inx 8390 43 1.09 1.09 CD cord-010092-uftc8inx 8390 44 % % NN cord-010092-uftc8inx 8390 45 ) ) -RRB- cord-010092-uftc8inx 8390 46 , , , cord-010092-uftc8inx 8390 47 30 30 CD cord-010092-uftc8inx 8390 48 donors donor NNS cord-010092-uftc8inx 8390 49 showed show VBD cord-010092-uftc8inx 8390 50 reactive reactive JJ cord-010092-uftc8inx 8390 51 IgM IgM NNP cord-010092-uftc8inx 8390 52 and and CC cord-010092-uftc8inx 8390 53 IgG IgG NNP cord-010092-uftc8inx 8390 54 titers titer NNS cord-010092-uftc8inx 8390 55 ( ( -LRB- cord-010092-uftc8inx 8390 56 10.95 10.95 CD cord-010092-uftc8inx 8390 57 % % NN cord-010092-uftc8inx 8390 58 ) ) -RRB- cord-010092-uftc8inx 8390 59 , , , cord-010092-uftc8inx 8390 60 25 25 CD cord-010092-uftc8inx 8390 61 donors donor NNS cord-010092-uftc8inx 8390 62 already already RB cord-010092-uftc8inx 8390 63 had have VBD cord-010092-uftc8inx 8390 64 isolated isolate VBN cord-010092-uftc8inx 8390 65 IgG igg NN cord-010092-uftc8inx 8390 66 titers titer NNS cord-010092-uftc8inx 8390 67 ( ( -LRB- cord-010092-uftc8inx 8390 68 9.12 9.12 CD cord-010092-uftc8inx 8390 69 % % NN cord-010092-uftc8inx 8390 70 ) ) -RRB- cord-010092-uftc8inx 8390 71 . . . cord-010092-uftc8inx 8391 1 Median median JJ cord-010092-uftc8inx 8391 2 values value NNS cord-010092-uftc8inx 8391 3 of of IN cord-010092-uftc8inx 8391 4 viral viral JJ cord-010092-uftc8inx 8391 5 loads load NNS cord-010092-uftc8inx 8391 6 were be VBD cord-010092-uftc8inx 8391 7 approximately approximately RB cord-010092-uftc8inx 8391 8 twice twice RB cord-010092-uftc8inx 8391 9 as as RB cord-010092-uftc8inx 8391 10 high high JJ cord-010092-uftc8inx 8391 11 in in IN cord-010092-uftc8inx 8391 12 index index NN cord-010092-uftc8inx 8391 13 donations donation NNS cord-010092-uftc8inx 8391 14 that that WDT cord-010092-uftc8inx 8391 15 were be VBD cord-010092-uftc8inx 8391 16 antibody antibody JJ cord-010092-uftc8inx 8391 17 negative negative JJ cord-010092-uftc8inx 8391 18 . . . cord-010092-uftc8inx 8392 1 Merely merely RB cord-010092-uftc8inx 8392 2 62 62 CD cord-010092-uftc8inx 8392 3 donors donor NNS cord-010092-uftc8inx 8392 4 showed show VBD cord-010092-uftc8inx 8392 5 elevated elevated JJ cord-010092-uftc8inx 8392 6 ALT alt NN cord-010092-uftc8inx 8392 7 levels level NNS cord-010092-uftc8inx 8392 8 ( ( -LRB- cord-010092-uftc8inx 8392 9 22.63 22.63 CD cord-010092-uftc8inx 8392 10 % % NN cord-010092-uftc8inx 8392 11 ) ) -RRB- cord-010092-uftc8inx 8392 12 , , , cord-010092-uftc8inx 8392 13 mostly mostly RB cord-010092-uftc8inx 8392 14 within within IN cord-010092-uftc8inx 8392 15 a a DT cord-010092-uftc8inx 8392 16 double double JJ cord-010092-uftc8inx 8392 17 increase increase NN cord-010092-uftc8inx 8392 18 within within IN cord-010092-uftc8inx 8392 19 the the DT cord-010092-uftc8inx 8392 20 reference reference NN cord-010092-uftc8inx 8392 21 range range NN cord-010092-uftc8inx 8392 22 ( ( -LRB- cord-010092-uftc8inx 8392 23 16.06 16.06 CD cord-010092-uftc8inx 8392 24 % % NN cord-010092-uftc8inx 8392 25 ) ) -RRB- cord-010092-uftc8inx 8392 26 , , , cord-010092-uftc8inx 8392 27 only only RB cord-010092-uftc8inx 8392 28 6.57 6.57 CD cord-010092-uftc8inx 8392 29 % % NN cord-010092-uftc8inx 8392 30 of of IN cord-010092-uftc8inx 8392 31 donors donor NNS cord-010092-uftc8inx 8392 32 had have VBD cord-010092-uftc8inx 8392 33 even even RB cord-010092-uftc8inx 8392 34 further far RBR cord-010092-uftc8inx 8392 35 elevated elevate VBN cord-010092-uftc8inx 8392 36 ALT alt NN cord-010092-uftc8inx 8392 37 levels level NNS cord-010092-uftc8inx 8392 38 . . . cord-010092-uftc8inx 8393 1 Significantly significantly RB cord-010092-uftc8inx 8393 2 higher high JJR cord-010092-uftc8inx 8393 3 ALT alt NN cord-010092-uftc8inx 8393 4 values value NNS cord-010092-uftc8inx 8393 5 were be VBD cord-010092-uftc8inx 8393 6 found find VBN cord-010092-uftc8inx 8393 7 in in IN cord-010092-uftc8inx 8393 8 donors donor NNS cord-010092-uftc8inx 8393 9 with with IN cord-010092-uftc8inx 8393 10 a a DT cord-010092-uftc8inx 8393 11 viral viral JJ cord-010092-uftc8inx 8393 12 load load NN cord-010092-uftc8inx 8393 13 > > XX cord-010092-uftc8inx 8393 14 1,000 1,000 CD cord-010092-uftc8inx 8393 15 IU IU NNP cord-010092-uftc8inx 8393 16 / / , cord-010092-uftc8inx 8393 17 ml ml NNS cord-010092-uftc8inx 8393 18 compared compare VBN cord-010092-uftc8inx 8393 19 to to IN cord-010092-uftc8inx 8393 20 the the DT cord-010092-uftc8inx 8393 21 group group NN cord-010092-uftc8inx 8393 22 with with IN cord-010092-uftc8inx 8393 23 viral viral JJ cord-010092-uftc8inx 8393 24 loads load NNS cord-010092-uftc8inx 8394 1 between between IN cord-010092-uftc8inx 8394 2 100 100 CD cord-010092-uftc8inx 8394 3 and and CC cord-010092-uftc8inx 8394 4 1000 1000 CD cord-010092-uftc8inx 8394 5 IU IU NNP cord-010092-uftc8inx 8394 6 / / SYM cord-010092-uftc8inx 8394 7 mL. mL. NNS cord-010092-uftc8inx 8394 8 Available available JJ cord-010092-uftc8inx 8394 9 follow follow NN cord-010092-uftc8inx 8394 10 - - HYPH cord-010092-uftc8inx 8394 11 up up NN cord-010092-uftc8inx 8394 12 samples sample NNS cord-010092-uftc8inx 8394 13 confirmed confirm VBD cord-010092-uftc8inx 8394 14 IgG igg NN cord-010092-uftc8inx 8394 15 seroconversion seroconversion NN cord-010092-uftc8inx 8394 16 for for IN cord-010092-uftc8inx 8394 17 all all DT cord-010092-uftc8inx 8394 18 donors donor NNS cord-010092-uftc8inx 8394 19 , , , cord-010092-uftc8inx 8394 20 however however RB cord-010092-uftc8inx 8394 21 we -PRON- PRP cord-010092-uftc8inx 8394 22 also also RB cord-010092-uftc8inx 8394 23 observed observe VBD cord-010092-uftc8inx 8394 24 long long JJ cord-010092-uftc8inx 8394 25 - - HYPH cord-010092-uftc8inx 8394 26 term term NN cord-010092-uftc8inx 8394 27 IgM IgM NNP cord-010092-uftc8inx 8394 28 positivity positivity NN cord-010092-uftc8inx 8394 29 in in IN cord-010092-uftc8inx 8394 30 some some DT cord-010092-uftc8inx 8394 31 donors donor NNS cord-010092-uftc8inx 8394 32 . . . cord-010092-uftc8inx 8395 1 Genotyping genotype VBG cord-010092-uftc8inx 8395 2 revealed reveal VBD cord-010092-uftc8inx 8395 3 genotype genotype NN cord-010092-uftc8inx 8395 4 3 3 CD cord-010092-uftc8inx 8395 5 in in IN cord-010092-uftc8inx 8395 6 all all DT cord-010092-uftc8inx 8395 7 cases case NNS cord-010092-uftc8inx 8395 8 . . . cord-010092-uftc8inx 8396 1 The the DT cord-010092-uftc8inx 8396 2 month month NN cord-010092-uftc8inx 8396 3 - - HYPH cord-010092-uftc8inx 8396 4 dependent dependent JJ cord-010092-uftc8inx 8396 5 incidence incidence NN cord-010092-uftc8inx 8396 6 ranges range VBZ cord-010092-uftc8inx 8396 7 from from IN cord-010092-uftc8inx 8396 8 1:719 1:719 CD cord-010092-uftc8inx 8396 9 to to IN cord-010092-uftc8inx 8396 10 1:3,781 1:3,781 CD cord-010092-uftc8inx 8396 11 blood blood NN cord-010092-uftc8inx 8396 12 donations donation NNS cord-010092-uftc8inx 8396 13 with with IN cord-010092-uftc8inx 8396 14 a a DT cord-010092-uftc8inx 8396 15 peak peak NN cord-010092-uftc8inx 8396 16 in in IN cord-010092-uftc8inx 8396 17 June June NNP cord-010092-uftc8inx 8396 18 and and CC cord-010092-uftc8inx 8396 19 July July NNP cord-010092-uftc8inx 8396 20 . . . cord-010092-uftc8inx 8397 1 Summary Summary NNP cord-010092-uftc8inx 8397 2 / / SYM cord-010092-uftc8inx 8397 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 8397 4 : : : cord-010092-uftc8inx 8398 1 The the DT cord-010092-uftc8inx 8398 2 high high JJ cord-010092-uftc8inx 8398 3 number number NN cord-010092-uftc8inx 8398 4 of of IN cord-010092-uftc8inx 8398 5 identified identify VBN cord-010092-uftc8inx 8398 6 HEV HEV NNP cord-010092-uftc8inx 8398 7 RNA RNA NNP cord-010092-uftc8inx 8398 8 positive positive JJ cord-010092-uftc8inx 8398 9 donors donor NNS cord-010092-uftc8inx 8398 10 emphasizes emphasize VBZ cord-010092-uftc8inx 8398 11 the the DT cord-010092-uftc8inx 8398 12 need need NN cord-010092-uftc8inx 8398 13 for for IN cord-010092-uftc8inx 8398 14 HEV HEV NNP cord-010092-uftc8inx 8398 15 - - HYPH cord-010092-uftc8inx 8398 16 NAT NAT NNP cord-010092-uftc8inx 8398 17 screening screening NN cord-010092-uftc8inx 8398 18 to to TO cord-010092-uftc8inx 8398 19 increase increase VB cord-010092-uftc8inx 8398 20 the the DT cord-010092-uftc8inx 8398 21 safety safety NN cord-010092-uftc8inx 8398 22 of of IN cord-010092-uftc8inx 8398 23 blood blood NN cord-010092-uftc8inx 8398 24 products product NNS cord-010092-uftc8inx 8398 25 . . . cord-010092-uftc8inx 8399 1 This this DT cord-010092-uftc8inx 8399 2 study study NN cord-010092-uftc8inx 8399 3 further further RB cord-010092-uftc8inx 8399 4 confirmed confirm VBD cord-010092-uftc8inx 8399 5 that that IN cord-010092-uftc8inx 8399 6 HEV HEV NNP cord-010092-uftc8inx 8399 7 infection infection NN cord-010092-uftc8inx 8399 8 is be VBZ cord-010092-uftc8inx 8399 9 common common JJ cord-010092-uftc8inx 8399 10 in in IN cord-010092-uftc8inx 8399 11 German german JJ cord-010092-uftc8inx 8399 12 blood blood NN cord-010092-uftc8inx 8399 13 donors donor NNS cord-010092-uftc8inx 8399 14 . . . cord-010092-uftc8inx 8400 1 Background background NN cord-010092-uftc8inx 8400 2 : : : cord-010092-uftc8inx 8401 1 Zika Zika NNP cord-010092-uftc8inx 8401 2 virus virus NN cord-010092-uftc8inx 8401 3 ( ( -LRB- cord-010092-uftc8inx 8401 4 ZIKV ZIKV NNP cord-010092-uftc8inx 8401 5 ) ) -RRB- cord-010092-uftc8inx 8401 6 is be VBZ cord-010092-uftc8inx 8401 7 a a DT cord-010092-uftc8inx 8401 8 mosquito mosquito NN cord-010092-uftc8inx 8401 9 - - HYPH cord-010092-uftc8inx 8401 10 borne bear VBN cord-010092-uftc8inx 8401 11 virus virus NN cord-010092-uftc8inx 8401 12 that that WDT cord-010092-uftc8inx 8401 13 has have VBZ cord-010092-uftc8inx 8401 14 caused cause VBN cord-010092-uftc8inx 8401 15 outbreaks outbreak NNS cord-010092-uftc8inx 8401 16 in in IN cord-010092-uftc8inx 8401 17 Central Central NNP cord-010092-uftc8inx 8401 18 and and CC cord-010092-uftc8inx 8401 19 South South NNP cord-010092-uftc8inx 8401 20 America America NNP cord-010092-uftc8inx 8401 21 in in IN cord-010092-uftc8inx 8401 22 February February NNP cord-010092-uftc8inx 8401 23 2016 2016 CD cord-010092-uftc8inx 8401 24 , , , cord-010092-uftc8inx 8401 25 and and CC cord-010092-uftc8inx 8401 26 has have VBZ cord-010092-uftc8inx 8401 27 threatened threaten VBN cord-010092-uftc8inx 8401 28 the the DT cord-010092-uftc8inx 8401 29 safety safety NN cord-010092-uftc8inx 8401 30 of of IN cord-010092-uftc8inx 8401 31 blood blood NN cord-010092-uftc8inx 8401 32 transfusion transfusion NN cord-010092-uftc8inx 8401 33 globally globally RB cord-010092-uftc8inx 8401 34 . . . cord-010092-uftc8inx 8402 1 There there EX cord-010092-uftc8inx 8402 2 is be VBZ cord-010092-uftc8inx 8402 3 a a DT cord-010092-uftc8inx 8402 4 high high JJ cord-010092-uftc8inx 8402 5 risk risk NN cord-010092-uftc8inx 8402 6 of of IN cord-010092-uftc8inx 8402 7 ZIKV ZIKV NNP cord-010092-uftc8inx 8402 8 transmission transmission NN cord-010092-uftc8inx 8402 9 by by IN cord-010092-uftc8inx 8402 10 Whole Whole NNP cord-010092-uftc8inx 8402 11 Blood blood NN cord-010092-uftc8inx 8402 12 and and CC cord-010092-uftc8inx 8402 13 blood blood NN cord-010092-uftc8inx 8402 14 components component NNS cord-010092-uftc8inx 8402 15 transfusion transfusion NN cord-010092-uftc8inx 8402 16 . . . cord-010092-uftc8inx 8403 1 It -PRON- PRP cord-010092-uftc8inx 8403 2 was be VBD cord-010092-uftc8inx 8403 3 reported report VBN cord-010092-uftc8inx 8403 4 that that IN cord-010092-uftc8inx 8403 5 , , , cord-010092-uftc8inx 8403 6 ZIKV ZIKV NNP cord-010092-uftc8inx 8403 7 RNA RNA NNP cord-010092-uftc8inx 8403 8 in in IN cord-010092-uftc8inx 8403 9 infected infected JJ cord-010092-uftc8inx 8403 10 patients patient NNS cord-010092-uftc8inx 8403 11 plasma plasma NN cord-010092-uftc8inx 8403 12 can can MD cord-010092-uftc8inx 8403 13 only only RB cord-010092-uftc8inx 8403 14 be be VB cord-010092-uftc8inx 8403 15 detected detect VBN cord-010092-uftc8inx 8403 16 within within IN cord-010092-uftc8inx 8403 17 1 1 CD cord-010092-uftc8inx 8403 18 to to IN cord-010092-uftc8inx 8403 19 2 2 CD cord-010092-uftc8inx 8403 20 weeks week NNS cord-010092-uftc8inx 8403 21 . . . cord-010092-uftc8inx 8404 1 However however RB cord-010092-uftc8inx 8404 2 , , , cord-010092-uftc8inx 8404 3 in in IN cord-010092-uftc8inx 8404 4 whole whole JJ cord-010092-uftc8inx 8404 5 blood blood NN cord-010092-uftc8inx 8404 6 , , , cord-010092-uftc8inx 8404 7 ZIKV ZIKV NNP cord-010092-uftc8inx 8404 8 RNA RNA NNP cord-010092-uftc8inx 8404 9 might may MD cord-010092-uftc8inx 8404 10 present present VB cord-010092-uftc8inx 8404 11 positive positive JJ cord-010092-uftc8inx 8404 12 up up RP cord-010092-uftc8inx 8404 13 to to IN cord-010092-uftc8inx 8404 14 day day NN cord-010092-uftc8inx 8404 15 101 101 CD cord-010092-uftc8inx 8404 16 after after IN cord-010092-uftc8inx 8404 17 the the DT cord-010092-uftc8inx 8404 18 symptoms symptom NNS cord-010092-uftc8inx 8404 19 appear appear VBP cord-010092-uftc8inx 8404 20 in in IN cord-010092-uftc8inx 8404 21 some some DT cord-010092-uftc8inx 8404 22 patients patient NNS cord-010092-uftc8inx 8404 23 , , , cord-010092-uftc8inx 8404 24 even even RB cord-010092-uftc8inx 8404 25 if if IN cord-010092-uftc8inx 8404 26 the the DT cord-010092-uftc8inx 8404 27 clinical clinical JJ cord-010092-uftc8inx 8404 28 symptoms symptom NNS cord-010092-uftc8inx 8404 29 disappeared disappear VBD cord-010092-uftc8inx 8404 30 with with IN cord-010092-uftc8inx 8404 31 ZIKV ZIKV NNP cord-010092-uftc8inx 8404 32 RNA RNA NNP cord-010092-uftc8inx 8404 33 negative negative JJ cord-010092-uftc8inx 8404 34 in in IN cord-010092-uftc8inx 8404 35 plasma plasma NN cord-010092-uftc8inx 8404 36 . . . cord-010092-uftc8inx 8405 1 This this DT cord-010092-uftc8inx 8405 2 phenomenon phenomenon NN cord-010092-uftc8inx 8405 3 suggested suggest VBD cord-010092-uftc8inx 8405 4 that that IN cord-010092-uftc8inx 8405 5 the the DT cord-010092-uftc8inx 8405 6 presence presence NN cord-010092-uftc8inx 8405 7 of of IN cord-010092-uftc8inx 8405 8 ZIKA ZIKA NNP cord-010092-uftc8inx 8405 9 is be VBZ cord-010092-uftc8inx 8405 10 associated associate VBN cord-010092-uftc8inx 8405 11 with with IN cord-010092-uftc8inx 8405 12 red red JJ cord-010092-uftc8inx 8405 13 blood blood NN cord-010092-uftc8inx 8405 14 cells cell NNS cord-010092-uftc8inx 8405 15 ( ( -LRB- cord-010092-uftc8inx 8405 16 RBCs rbc NNS cord-010092-uftc8inx 8405 17 ) ) -RRB- cord-010092-uftc8inx 8405 18 . . . cord-010092-uftc8inx 8406 1 Moreover moreover RB cord-010092-uftc8inx 8406 2 , , , cord-010092-uftc8inx 8406 3 another another DT cord-010092-uftc8inx 8406 4 report report NN cord-010092-uftc8inx 8406 5 showed show VBD cord-010092-uftc8inx 8406 6 that that IN cord-010092-uftc8inx 8406 7 viral viral JJ cord-010092-uftc8inx 8406 8 load load NN cord-010092-uftc8inx 8406 9 in in IN cord-010092-uftc8inx 8406 10 whole whole JJ cord-010092-uftc8inx 8406 11 blood blood NN cord-010092-uftc8inx 8406 12 of of IN cord-010092-uftc8inx 8406 13 type type NN cord-010092-uftc8inx 8406 14 A a DT cord-010092-uftc8inx 8406 15 West West NNP cord-010092-uftc8inx 8406 16 Nile Nile NNP cord-010092-uftc8inx 8406 17 virus virus NN cord-010092-uftc8inx 8406 18 ( ( -LRB- cord-010092-uftc8inx 8406 19 WNV WNV NNP cord-010092-uftc8inx 8406 20 ) ) -RRB- cord-010092-uftc8inx 8406 21 patients patient NNS cord-010092-uftc8inx 8406 22 was be VBD cord-010092-uftc8inx 8406 23 higher high JJR cord-010092-uftc8inx 8406 24 than than IN cord-010092-uftc8inx 8406 25 type type NN cord-010092-uftc8inx 8406 26 O o NN cord-010092-uftc8inx 8406 27 , , , cord-010092-uftc8inx 8406 28 implying imply VBG cord-010092-uftc8inx 8406 29 that that IN cord-010092-uftc8inx 8406 30 the the DT cord-010092-uftc8inx 8406 31 binding binding NN cord-010092-uftc8inx 8406 32 of of IN cord-010092-uftc8inx 8406 33 virus virus NN cord-010092-uftc8inx 8406 34 to to IN cord-010092-uftc8inx 8406 35 RBCs rbc NNS cord-010092-uftc8inx 8406 36 may may MD cord-010092-uftc8inx 8406 37 be be VB cord-010092-uftc8inx 8406 38 related relate VBN cord-010092-uftc8inx 8406 39 to to IN cord-010092-uftc8inx 8406 40 blood blood NN cord-010092-uftc8inx 8406 41 group group NN cord-010092-uftc8inx 8406 42 glycoprotein glycoprotein NN cord-010092-uftc8inx 8406 43 . . . cord-010092-uftc8inx 8407 1 Both both DT cord-010092-uftc8inx 8407 2 of of IN cord-010092-uftc8inx 8407 3 ZIKV ZIKV NNP cord-010092-uftc8inx 8407 4 and and CC cord-010092-uftc8inx 8407 5 WNV WNV NNP cord-010092-uftc8inx 8407 6 are be VBP cord-010092-uftc8inx 8407 7 member member NN cord-010092-uftc8inx 8407 8 of of IN cord-010092-uftc8inx 8407 9 the the DT cord-010092-uftc8inx 8407 10 Flavivirus Flavivirus NNP cord-010092-uftc8inx 8407 11 genus genus NN cord-010092-uftc8inx 8407 12 . . . cord-010092-uftc8inx 8408 1 The the DT cord-010092-uftc8inx 8408 2 study study NN cord-010092-uftc8inx 8408 3 is be VBZ cord-010092-uftc8inx 8408 4 intended intend VBN cord-010092-uftc8inx 8408 5 to to TO cord-010092-uftc8inx 8408 6 explore explore VB cord-010092-uftc8inx 8408 7 whether whether IN cord-010092-uftc8inx 8408 8 ZIKV ZIKV NNP cord-010092-uftc8inx 8408 9 have have VBP cord-010092-uftc8inx 8408 10 the the DT cord-010092-uftc8inx 8408 11 same same JJ cord-010092-uftc8inx 8408 12 adherence adherence NN cord-010092-uftc8inx 8408 13 mechanism mechanism NN cord-010092-uftc8inx 8408 14 to to IN cord-010092-uftc8inx 8408 15 RBCs rbc NNS cord-010092-uftc8inx 8408 16 as as IN cord-010092-uftc8inx 8408 17 WNV WNV NNP cord-010092-uftc8inx 8408 18 . . . cord-010092-uftc8inx 8409 1 Aims aim VBZ cord-010092-uftc8inx 8409 2 : : : cord-010092-uftc8inx 8409 3 To to TO cord-010092-uftc8inx 8409 4 investigate investigate VB cord-010092-uftc8inx 8409 5 the the DT cord-010092-uftc8inx 8409 6 distribution distribution NN cord-010092-uftc8inx 8409 7 of of IN cord-010092-uftc8inx 8409 8 ZIKV ZIKV NNP cord-010092-uftc8inx 8409 9 in in IN cord-010092-uftc8inx 8409 10 blood blood NN cord-010092-uftc8inx 8409 11 components component NNS cord-010092-uftc8inx 8409 12 and and CC cord-010092-uftc8inx 8409 13 adherence adherence NN cord-010092-uftc8inx 8409 14 of of IN cord-010092-uftc8inx 8409 15 ZIKV ZIKV NNP cord-010092-uftc8inx 8409 16 to to IN cord-010092-uftc8inx 8409 17 different different JJ cord-010092-uftc8inx 8409 18 blood blood NN cord-010092-uftc8inx 8409 19 types type NNS cord-010092-uftc8inx 8409 20 of of IN cord-010092-uftc8inx 8409 21 RBCs rbc NNS cord-010092-uftc8inx 8409 22 in in IN cord-010092-uftc8inx 8409 23 whole whole JJ cord-010092-uftc8inx 8409 24 blood blood NN cord-010092-uftc8inx 8409 25 . . . cord-010092-uftc8inx 8410 1 Methods method NNS cord-010092-uftc8inx 8410 2 : : : cord-010092-uftc8inx 8410 3 Five five CD cord-010092-uftc8inx 8410 4 units unit NNS cord-010092-uftc8inx 8410 5 for for IN cord-010092-uftc8inx 8410 6 each each DT cord-010092-uftc8inx 8410 7 blood blood NN cord-010092-uftc8inx 8410 8 type type NN cord-010092-uftc8inx 8410 9 of of IN cord-010092-uftc8inx 8410 10 A a NN cord-010092-uftc8inx 8410 11 , , , cord-010092-uftc8inx 8410 12 B b NN cord-010092-uftc8inx 8410 13 , , , cord-010092-uftc8inx 8410 14 O o UH cord-010092-uftc8inx 8410 15 and and CC cord-010092-uftc8inx 8410 16 AB AB NNP cord-010092-uftc8inx 8410 17 whole whole JJ cord-010092-uftc8inx 8410 18 blood blood NN cord-010092-uftc8inx 8410 19 were be VBD cord-010092-uftc8inx 8410 20 randomly randomly RB cord-010092-uftc8inx 8410 21 selected select VBN cord-010092-uftc8inx 8410 22 . . . cord-010092-uftc8inx 8411 1 Each each DT cord-010092-uftc8inx 8411 2 unit unit NN cord-010092-uftc8inx 8411 3 of of IN cord-010092-uftc8inx 8411 4 200 200 CD cord-010092-uftc8inx 8411 5 mL ml NN cord-010092-uftc8inx 8411 6 whole whole JJ cord-010092-uftc8inx 8411 7 blood blood NN cord-010092-uftc8inx 8411 8 was be VBD cord-010092-uftc8inx 8411 9 divided divide VBN cord-010092-uftc8inx 8411 10 into into IN cord-010092-uftc8inx 8411 11 two two CD cord-010092-uftc8inx 8411 12 half half JJ cord-010092-uftc8inx 8411 13 - - HYPH cord-010092-uftc8inx 8411 14 unit unit NN cord-010092-uftc8inx 8411 15 . . . cord-010092-uftc8inx 8412 1 ZIKV ZIKV NNP cord-010092-uftc8inx 8412 2 was be VBD cord-010092-uftc8inx 8412 3 added add VBN cord-010092-uftc8inx 8412 4 to to IN cord-010092-uftc8inx 8412 5 one one CD cord-010092-uftc8inx 8412 6 half half JJ cord-010092-uftc8inx 8412 7 - - HYPH cord-010092-uftc8inx 8412 8 unit unit NN cord-010092-uftc8inx 8412 9 in in IN cord-010092-uftc8inx 8412 10 a a DT cord-010092-uftc8inx 8412 11 certain certain JJ cord-010092-uftc8inx 8412 12 proportion proportion NN cord-010092-uftc8inx 8412 13 , , , cord-010092-uftc8inx 8412 14 and and CC cord-010092-uftc8inx 8412 15 incubated incubate VBN cord-010092-uftc8inx 8412 16 at at IN cord-010092-uftc8inx 8412 17 37 37 CD cord-010092-uftc8inx 8412 18 ° ° NN cord-010092-uftc8inx 8412 19 C c NN cord-010092-uftc8inx 8412 20 for for IN cord-010092-uftc8inx 8412 21 3 3 CD cord-010092-uftc8inx 8412 22 days day NNS cord-010092-uftc8inx 8412 23 . . . cord-010092-uftc8inx 8413 1 Each each DT cord-010092-uftc8inx 8413 2 component component NN cord-010092-uftc8inx 8413 3 of of IN cord-010092-uftc8inx 8413 4 whole whole JJ cord-010092-uftc8inx 8413 5 blood blood NN cord-010092-uftc8inx 8413 6 was be VBD cord-010092-uftc8inx 8413 7 collected collect VBN cord-010092-uftc8inx 8413 8 for for IN cord-010092-uftc8inx 8413 9 viral viral JJ cord-010092-uftc8inx 8413 10 load load NN cord-010092-uftc8inx 8413 11 detection detection NN cord-010092-uftc8inx 8413 12 . . . cord-010092-uftc8inx 8414 1 In in IN cord-010092-uftc8inx 8414 2 the the DT cord-010092-uftc8inx 8414 3 other other JJ cord-010092-uftc8inx 8414 4 half half JJ cord-010092-uftc8inx 8414 5 - - HYPH cord-010092-uftc8inx 8414 6 unit unit NN cord-010092-uftc8inx 8414 7 , , , cord-010092-uftc8inx 8414 8 RBCs rbc NNS cord-010092-uftc8inx 8414 9 were be VBD cord-010092-uftc8inx 8414 10 suspended suspend VBN cord-010092-uftc8inx 8414 11 in in IN cord-010092-uftc8inx 8414 12 the the DT cord-010092-uftc8inx 8414 13 same same JJ cord-010092-uftc8inx 8414 14 type type NN cord-010092-uftc8inx 8414 15 pools pool NNS cord-010092-uftc8inx 8414 16 of of IN cord-010092-uftc8inx 8414 17 plasma plasma NN cord-010092-uftc8inx 8414 18 with with IN cord-010092-uftc8inx 8414 19 equal equal JJ cord-010092-uftc8inx 8414 20 volume volume NN cord-010092-uftc8inx 8414 21 after after IN cord-010092-uftc8inx 8414 22 the the DT cord-010092-uftc8inx 8414 23 plasma plasma NN cord-010092-uftc8inx 8414 24 removed remove VBN cord-010092-uftc8inx 8414 25 from from IN cord-010092-uftc8inx 8414 26 the the DT cord-010092-uftc8inx 8414 27 whole whole JJ cord-010092-uftc8inx 8414 28 blood blood NN cord-010092-uftc8inx 8414 29 after after IN cord-010092-uftc8inx 8414 30 centrifugation centrifugation NN cord-010092-uftc8inx 8414 31 . . . cord-010092-uftc8inx 8415 1 ZIKV ZIKV NNP cord-010092-uftc8inx 8415 2 was be VBD cord-010092-uftc8inx 8415 3 added add VBN cord-010092-uftc8inx 8415 4 with with IN cord-010092-uftc8inx 8415 5 the the DT cord-010092-uftc8inx 8415 6 same same JJ cord-010092-uftc8inx 8415 7 certain certain JJ cord-010092-uftc8inx 8415 8 proportion proportion NN cord-010092-uftc8inx 8415 9 , , , cord-010092-uftc8inx 8415 10 and and CC cord-010092-uftc8inx 8415 11 then then RB cord-010092-uftc8inx 8415 12 incubated incubate VBD cord-010092-uftc8inx 8415 13 at at IN cord-010092-uftc8inx 8415 14 37 37 CD cord-010092-uftc8inx 8415 15 ° ° NN cord-010092-uftc8inx 8415 16 C c NN cord-010092-uftc8inx 8415 17 for for IN cord-010092-uftc8inx 8415 18 3 3 CD cord-010092-uftc8inx 8415 19 days day NNS cord-010092-uftc8inx 8415 20 . . . cord-010092-uftc8inx 8416 1 The the DT cord-010092-uftc8inx 8416 2 whole whole JJ cord-010092-uftc8inx 8416 3 blood blood NN cord-010092-uftc8inx 8416 4 samples sample NNS cord-010092-uftc8inx 8416 5 and and CC cord-010092-uftc8inx 8416 6 the the DT cord-010092-uftc8inx 8416 7 upper upper JJ cord-010092-uftc8inx 8416 8 plasma plasma NN cord-010092-uftc8inx 8416 9 by by IN cord-010092-uftc8inx 8416 10 centrifugation centrifugation NN cord-010092-uftc8inx 8416 11 were be VBD cord-010092-uftc8inx 8416 12 collected collect VBN cord-010092-uftc8inx 8416 13 detected detect VBN cord-010092-uftc8inx 8416 14 for for IN cord-010092-uftc8inx 8416 15 ZIKV ZIKV NNP cord-010092-uftc8inx 8416 16 RNA RNA NNP cord-010092-uftc8inx 8416 17 . . . cord-010092-uftc8inx 8417 1 Meanwhile meanwhile RB cord-010092-uftc8inx 8417 2 , , , cord-010092-uftc8inx 8417 3 RBCs rbc NNS cord-010092-uftc8inx 8417 4 were be VBD cord-010092-uftc8inx 8417 5 washed wash VBN cord-010092-uftc8inx 8417 6 and and CC cord-010092-uftc8inx 8417 7 resuspended resuspend VBN cord-010092-uftc8inx 8417 8 with with IN cord-010092-uftc8inx 8417 9 normal normal JJ cord-010092-uftc8inx 8417 10 saline saline NN cord-010092-uftc8inx 8417 11 followed follow VBN cord-010092-uftc8inx 8417 12 by by IN cord-010092-uftc8inx 8417 13 viral viral JJ cord-010092-uftc8inx 8417 14 load load NN cord-010092-uftc8inx 8417 15 detection detection NN cord-010092-uftc8inx 8417 16 . . . cord-010092-uftc8inx 8418 1 Results result NNS cord-010092-uftc8inx 8418 2 : : : cord-010092-uftc8inx 8419 1 ZIKA ZIKA NNP cord-010092-uftc8inx 8419 2 RNA RNA NNP cord-010092-uftc8inx 8419 3 of of IN cord-010092-uftc8inx 8419 4 these these DT cord-010092-uftc8inx 8419 5 samples sample NNS cord-010092-uftc8inx 8419 6 which which WDT cord-010092-uftc8inx 8419 7 extracted extract VBD cord-010092-uftc8inx 8419 8 from from IN cord-010092-uftc8inx 8419 9 whole whole JJ cord-010092-uftc8inx 8419 10 blood blood NN cord-010092-uftc8inx 8419 11 , , , cord-010092-uftc8inx 8419 12 RBCs rbc NNS cord-010092-uftc8inx 8419 13 , , , cord-010092-uftc8inx 8419 14 and and CC cord-010092-uftc8inx 8419 15 plasma plasma NN cord-010092-uftc8inx 8419 16 were be VBD cord-010092-uftc8inx 8419 17 determined determine VBN cord-010092-uftc8inx 8419 18 in in IN cord-010092-uftc8inx 8419 19 a a DT cord-010092-uftc8inx 8419 20 quantitative quantitative JJ cord-010092-uftc8inx 8419 21 reverse reverse NN cord-010092-uftc8inx 8419 22 transcription transcription NN cord-010092-uftc8inx 8419 23 PCR PCR NNP cord-010092-uftc8inx 8419 24 , , , cord-010092-uftc8inx 8419 25 and and CC cord-010092-uftc8inx 8419 26 viral viral JJ cord-010092-uftc8inx 8419 27 RNA rna NN cord-010092-uftc8inx 8419 28 of of IN cord-010092-uftc8inx 8419 29 each each DT cord-010092-uftc8inx 8419 30 component component NN cord-010092-uftc8inx 8419 31 was be VBD cord-010092-uftc8inx 8419 32 all all RB cord-010092-uftc8inx 8419 33 up up IN cord-010092-uftc8inx 8419 34 to to TO cord-010092-uftc8inx 8419 35 10 10 CD cord-010092-uftc8inx 8419 36 9 9 CD cord-010092-uftc8inx 8419 37 copies/ copies/ CD cord-010092-uftc8inx 8420 1 mL. mL. NNP cord-010092-uftc8inx 8420 2 Although Although NNP cord-010092-uftc8inx 8420 3 , , , cord-010092-uftc8inx 8420 4 ZIKV ZIKV NNP cord-010092-uftc8inx 8420 5 RNA RNA NNP cord-010092-uftc8inx 8420 6 loads load NNS cord-010092-uftc8inx 8420 7 did do VBD cord-010092-uftc8inx 8420 8 not not RB cord-010092-uftc8inx 8420 9 show show VB cord-010092-uftc8inx 8420 10 significant significant JJ cord-010092-uftc8inx 8420 11 difference difference NN cord-010092-uftc8inx 8420 12 in in IN cord-010092-uftc8inx 8420 13 distribution distribution NN cord-010092-uftc8inx 8420 14 between between IN cord-010092-uftc8inx 8420 15 RBCs rbc NNS cord-010092-uftc8inx 8420 16 and and CC cord-010092-uftc8inx 8420 17 their -PRON- PRP$ cord-010092-uftc8inx 8420 18 corresponding correspond VBG cord-010092-uftc8inx 8420 19 plasma plasma NN cord-010092-uftc8inx 8420 20 components component NNS cord-010092-uftc8inx 8420 21 , , , cord-010092-uftc8inx 8420 22 ZIKV ZIKV NNP cord-010092-uftc8inx 8420 23 RNA RNA NNP cord-010092-uftc8inx 8420 24 quantification quantification NN cord-010092-uftc8inx 8420 25 were be VBD cord-010092-uftc8inx 8420 26 significantly significantly RB cord-010092-uftc8inx 8420 27 higher high JJR cord-010092-uftc8inx 8420 28 than than IN cord-010092-uftc8inx 8420 29 those those DT cord-010092-uftc8inx 8420 30 in in IN cord-010092-uftc8inx 8420 31 plasma plasma NN cord-010092-uftc8inx 8420 32 ( ( -LRB- cord-010092-uftc8inx 8420 33 P p NN cord-010092-uftc8inx 8420 34 < < XX cord-010092-uftc8inx 8420 35 0.05 0.05 CD cord-010092-uftc8inx 8420 36 ) ) -RRB- cord-010092-uftc8inx 8420 37 in in IN cord-010092-uftc8inx 8420 38 type type NN cord-010092-uftc8inx 8420 39 O o NN cord-010092-uftc8inx 8420 40 RBCs rbc NNS cord-010092-uftc8inx 8420 41 and and CC cord-010092-uftc8inx 8420 42 lower low JJR cord-010092-uftc8inx 8420 43 than than IN cord-010092-uftc8inx 8420 44 those those DT cord-010092-uftc8inx 8420 45 in in IN cord-010092-uftc8inx 8420 46 plasma plasma NN cord-010092-uftc8inx 8420 47 ( ( -LRB- cord-010092-uftc8inx 8420 48 P p NN cord-010092-uftc8inx 8420 49 < < XX cord-010092-uftc8inx 8420 50 0.05 0.05 CD cord-010092-uftc8inx 8420 51 ) ) -RRB- cord-010092-uftc8inx 8420 52 in in IN cord-010092-uftc8inx 8420 53 type type NN cord-010092-uftc8inx 8420 54 AB AB NNP cord-010092-uftc8inx 8420 55 RBCs rbc NNS cord-010092-uftc8inx 8420 56 . . . cord-010092-uftc8inx 8421 1 Summary Summary NNP cord-010092-uftc8inx 8421 2 / / SYM cord-010092-uftc8inx 8421 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 8421 4 : : : cord-010092-uftc8inx 8422 1 In in IN cord-010092-uftc8inx 8422 2 our -PRON- PRP$ cord-010092-uftc8inx 8422 3 study study NN cord-010092-uftc8inx 8422 4 , , , cord-010092-uftc8inx 8422 5 we -PRON- PRP cord-010092-uftc8inx 8422 6 detected detect VBD cord-010092-uftc8inx 8422 7 high high JJ cord-010092-uftc8inx 8422 8 viral viral JJ cord-010092-uftc8inx 8422 9 RNA rna NN cord-010092-uftc8inx 8422 10 loads load NNS cord-010092-uftc8inx 8422 11 in in IN cord-010092-uftc8inx 8422 12 RBCs rbc NNS cord-010092-uftc8inx 8422 13 . . . cord-010092-uftc8inx 8423 1 It -PRON- PRP cord-010092-uftc8inx 8423 2 was be VBD cord-010092-uftc8inx 8423 3 demonstrated demonstrate VBN cord-010092-uftc8inx 8423 4 that that IN cord-010092-uftc8inx 8423 5 ZIKV ZIKV NNP cord-010092-uftc8inx 8423 6 adheres adhere VBZ cord-010092-uftc8inx 8423 7 to to IN cord-010092-uftc8inx 8423 8 erythrocyte erythrocyte NN cord-010092-uftc8inx 8423 9 in in IN cord-010092-uftc8inx 8423 10 whole whole JJ cord-010092-uftc8inx 8423 11 blood blood NN cord-010092-uftc8inx 8423 12 , , , cord-010092-uftc8inx 8423 13 and and CC cord-010092-uftc8inx 8423 14 the the DT cord-010092-uftc8inx 8423 15 blood blood NN cord-010092-uftc8inx 8423 16 type type NN cord-010092-uftc8inx 8423 17 may may MD cord-010092-uftc8inx 8423 18 have have VB cord-010092-uftc8inx 8423 19 influence influence NN cord-010092-uftc8inx 8423 20 on on IN cord-010092-uftc8inx 8423 21 the the DT cord-010092-uftc8inx 8423 22 adherence adherence NN cord-010092-uftc8inx 8423 23 . . . cord-010092-uftc8inx 8424 1 Background background NN cord-010092-uftc8inx 8424 2 : : : cord-010092-uftc8inx 8425 1 Hong Hong NNP cord-010092-uftc8inx 8425 2 Kong Kong NNP cord-010092-uftc8inx 8425 3 is be VBZ cord-010092-uftc8inx 8425 4 not not RB cord-010092-uftc8inx 8425 5 endemic endemic JJ cord-010092-uftc8inx 8425 6 for for IN cord-010092-uftc8inx 8425 7 dengue dengue NN cord-010092-uftc8inx 8425 8 virus virus NN cord-010092-uftc8inx 8425 9 ( ( -LRB- cord-010092-uftc8inx 8425 10 DENV DENV NNP cord-010092-uftc8inx 8425 11 ) ) -RRB- cord-010092-uftc8inx 8425 12 with with IN cord-010092-uftc8inx 8425 13 most most JJS cord-010092-uftc8inx 8425 14 of of IN cord-010092-uftc8inx 8425 15 the the DT cord-010092-uftc8inx 8425 16 documented document VBN cord-010092-uftc8inx 8425 17 cases case NNS cord-010092-uftc8inx 8425 18 being be VBG cord-010092-uftc8inx 8425 19 imported import VBN cord-010092-uftc8inx 8425 20 . . . cord-010092-uftc8inx 8426 1 The the DT cord-010092-uftc8inx 8426 2 presence presence NN cord-010092-uftc8inx 8426 3 of of IN cord-010092-uftc8inx 8426 4 sufficient sufficient JJ cord-010092-uftc8inx 8426 5 number number NN cord-010092-uftc8inx 8426 6 of of IN cord-010092-uftc8inx 8426 7 mosquito mosquito NN cord-010092-uftc8inx 8426 8 vectors vector NNS cord-010092-uftc8inx 8426 9 , , , cord-010092-uftc8inx 8426 10 Aedes Aedes NNP cord-010092-uftc8inx 8426 11 albopictus albopictus NN cord-010092-uftc8inx 8426 12 , , , cord-010092-uftc8inx 8426 13 in in IN cord-010092-uftc8inx 8426 14 the the DT cord-010092-uftc8inx 8426 15 territory territory NN cord-010092-uftc8inx 8426 16 has have VBZ cord-010092-uftc8inx 8426 17 led lead VBN cord-010092-uftc8inx 8426 18 to to IN cord-010092-uftc8inx 8426 19 two two CD cord-010092-uftc8inx 8426 20 self self NN cord-010092-uftc8inx 8426 21 - - HYPH cord-010092-uftc8inx 8426 22 limiting limit VBG cord-010092-uftc8inx 8426 23 indigenous indigenous JJ cord-010092-uftc8inx 8426 24 outbreaks outbreak NNS cord-010092-uftc8inx 8426 25 affecting affect VBG cord-010092-uftc8inx 8426 26 20 20 CD cord-010092-uftc8inx 8426 27 residents resident NNS cord-010092-uftc8inx 8426 28 from from IN cord-010092-uftc8inx 8426 29 2000 2000 CD cord-010092-uftc8inx 8426 30 to to IN cord-010092-uftc8inx 8426 31 2014 2014 CD cord-010092-uftc8inx 8426 32 . . . cord-010092-uftc8inx 8427 1 During during IN cord-010092-uftc8inx 8427 2 14 14 CD cord-010092-uftc8inx 8427 3 August August NNP cord-010092-uftc8inx 8427 4 to to IN cord-010092-uftc8inx 8427 5 4 4 CD cord-010092-uftc8inx 8427 6 September September NNP cord-010092-uftc8inx 8427 7 2018 2018 CD cord-010092-uftc8inx 8427 8 , , , cord-010092-uftc8inx 8427 9 another another DT cord-010092-uftc8inx 8427 10 outbreak outbreak NN cord-010092-uftc8inx 8427 11 of of IN cord-010092-uftc8inx 8427 12 29 29 CD cord-010092-uftc8inx 8427 13 confirmed confirm VBN cord-010092-uftc8inx 8427 14 cases case NNS cord-010092-uftc8inx 8427 15 of of IN cord-010092-uftc8inx 8427 16 autochthonous autochthonous JJ cord-010092-uftc8inx 8427 17 dengue dengue NN cord-010092-uftc8inx 8427 18 fever fever NN cord-010092-uftc8inx 8427 19 were be VBD cord-010092-uftc8inx 8427 20 reported report VBN cord-010092-uftc8inx 8427 21 to to IN cord-010092-uftc8inx 8427 22 the the DT cord-010092-uftc8inx 8427 23 Department Department NNP cord-010092-uftc8inx 8427 24 of of IN cord-010092-uftc8inx 8427 25 Health Health NNP cord-010092-uftc8inx 8427 26 , , , cord-010092-uftc8inx 8427 27 linked link VBN cord-010092-uftc8inx 8427 28 to to IN cord-010092-uftc8inx 8427 29 two two CD cord-010092-uftc8inx 8427 30 epidemiological epidemiological JJ cord-010092-uftc8inx 8427 31 clusters cluster NNS cord-010092-uftc8inx 8427 32 , , , cord-010092-uftc8inx 8427 33 one one CD cord-010092-uftc8inx 8427 34 in in IN cord-010092-uftc8inx 8427 35 Lion Lion NNP cord-010092-uftc8inx 8427 36 Rock Rock NNP cord-010092-uftc8inx 8427 37 Park Park NNP cord-010092-uftc8inx 8427 38 near near IN cord-010092-uftc8inx 8427 39 Wong Wong NNP cord-010092-uftc8inx 8427 40 Tai Tai NNP cord-010092-uftc8inx 8427 41 Sin Sin NNP cord-010092-uftc8inx 8427 42 ( ( -LRB- cord-010092-uftc8inx 8427 43 WTS WTS NNP cord-010092-uftc8inx 8427 44 ) ) -RRB- cord-010092-uftc8inx 8427 45 District District NNP cord-010092-uftc8inx 8427 46 ( ( -LRB- cord-010092-uftc8inx 8427 47 19 19 CD cord-010092-uftc8inx 8427 48 cases case NNS cord-010092-uftc8inx 8427 49 ) ) -RRB- cord-010092-uftc8inx 8427 50 and and CC cord-010092-uftc8inx 8427 51 the the DT cord-010092-uftc8inx 8427 52 other other JJ cord-010092-uftc8inx 8427 53 in in IN cord-010092-uftc8inx 8427 54 Cheung Cheung NNP cord-010092-uftc8inx 8427 55 Chau Chau NNP cord-010092-uftc8inx 8427 56 , , , cord-010092-uftc8inx 8427 57 an an DT cord-010092-uftc8inx 8427 58 outlying outlying JJ cord-010092-uftc8inx 8427 59 island island NN cord-010092-uftc8inx 8427 60 ( ( -LRB- cord-010092-uftc8inx 8427 61 10 10 CD cord-010092-uftc8inx 8427 62 cases case NNS cord-010092-uftc8inx 8427 63 ) ) -RRB- cord-010092-uftc8inx 8427 64 . . . cord-010092-uftc8inx 8428 1 Aims aim VBZ cord-010092-uftc8inx 8428 2 : : : cord-010092-uftc8inx 8428 3 We -PRON- PRP cord-010092-uftc8inx 8428 4 assessed assess VBD cord-010092-uftc8inx 8428 5 the the DT cord-010092-uftc8inx 8428 6 risk risk NN cord-010092-uftc8inx 8428 7 of of IN cord-010092-uftc8inx 8428 8 dengue dengue NN cord-010092-uftc8inx 8428 9 transmission transmission NN cord-010092-uftc8inx 8428 10 from from IN cord-010092-uftc8inx 8428 11 blood blood NN cord-010092-uftc8inx 8428 12 donors donor NNS cord-010092-uftc8inx 8428 13 during during IN cord-010092-uftc8inx 8428 14 the the DT cord-010092-uftc8inx 8428 15 2018 2018 CD cord-010092-uftc8inx 8428 16 outbreak outbreak NN cord-010092-uftc8inx 8428 17 using use VBG cord-010092-uftc8inx 8428 18 a a DT cord-010092-uftc8inx 8428 19 simplified simplified JJ cord-010092-uftc8inx 8428 20 version version NN cord-010092-uftc8inx 8428 21 of of IN cord-010092-uftc8inx 8428 22 the the DT cord-010092-uftc8inx 8428 23 probabilistic probabilistic JJ cord-010092-uftc8inx 8428 24 model model NN cord-010092-uftc8inx 8428 25 developed develop VBN cord-010092-uftc8inx 8428 26 by by IN cord-010092-uftc8inx 8428 27 Biggerstaff Biggerstaff NNP cord-010092-uftc8inx 8428 28 and and CC cord-010092-uftc8inx 8428 29 Petersen Petersen NNP cord-010092-uftc8inx 8428 30 ( ( -LRB- cord-010092-uftc8inx 8428 31 B b NN cord-010092-uftc8inx 8428 32 - - HYPH cord-010092-uftc8inx 8428 33 P p NN cord-010092-uftc8inx 8428 34 ) ) -RRB- cord-010092-uftc8inx 8428 35 and and CC cord-010092-uftc8inx 8428 36 the the DT cord-010092-uftc8inx 8428 37 European European NNP cord-010092-uftc8inx 8428 38 Up Up NNP cord-010092-uftc8inx 8428 39 - - HYPH cord-010092-uftc8inx 8428 40 Front Front NNP cord-010092-uftc8inx 8428 41 Risk Risk NNP cord-010092-uftc8inx 8428 42 Assessment Assessment NNP cord-010092-uftc8inx 8428 43 Tool Tool NNP cord-010092-uftc8inx 8428 44 ( ( -LRB- cord-010092-uftc8inx 8428 45 EUFRAT EUFRAT NNP cord-010092-uftc8inx 8428 46 ) ) -RRB- cord-010092-uftc8inx 8428 47 model model NN cord-010092-uftc8inx 8428 48 ( ( -LRB- cord-010092-uftc8inx 8428 49 Oei Oei NNP cord-010092-uftc8inx 8428 50 , , , cord-010092-uftc8inx 8428 51 Transfusion Transfusion NNP cord-010092-uftc8inx 8428 52 , , , cord-010092-uftc8inx 8428 53 2013 2013 CD cord-010092-uftc8inx 8428 54 ) ) -RRB- cord-010092-uftc8inx 8428 55 . . . cord-010092-uftc8inx 8429 1 Methods method NNS cord-010092-uftc8inx 8429 2 : : : cord-010092-uftc8inx 8429 3 Patient patient JJ cord-010092-uftc8inx 8429 4 demographic demographic JJ cord-010092-uftc8inx 8429 5 and and CC cord-010092-uftc8inx 8429 6 general general JJ cord-010092-uftc8inx 8429 7 population population NN cord-010092-uftc8inx 8429 8 data datum NNS cord-010092-uftc8inx 8429 9 were be VBD cord-010092-uftc8inx 8429 10 obtained obtain VBN cord-010092-uftc8inx 8429 11 from from IN cord-010092-uftc8inx 8429 12 the the DT cord-010092-uftc8inx 8429 13 Centre Centre NNP cord-010092-uftc8inx 8429 14 for for IN cord-010092-uftc8inx 8429 15 Health Health NNP cord-010092-uftc8inx 8429 16 Protection Protection NNP cord-010092-uftc8inx 8429 17 and and CC cord-010092-uftc8inx 8429 18 the the DT cord-010092-uftc8inx 8429 19 Department Department NNP cord-010092-uftc8inx 8429 20 of of IN cord-010092-uftc8inx 8429 21 Census Census NNP cord-010092-uftc8inx 8429 22 and and CC cord-010092-uftc8inx 8429 23 Statistics Statistics NNPS cord-010092-uftc8inx 8429 24 of of IN cord-010092-uftc8inx 8429 25 the the DT cord-010092-uftc8inx 8429 26 Hong Hong NNP cord-010092-uftc8inx 8429 27 Kong Kong NNP cord-010092-uftc8inx 8429 28 Government Government NNP cord-010092-uftc8inx 8429 29 for for IN cord-010092-uftc8inx 8429 30 the the DT cord-010092-uftc8inx 8429 31 number number NN cord-010092-uftc8inx 8429 32 of of IN cord-010092-uftc8inx 8429 33 15-to 15-to CD cord-010092-uftc8inx 8429 34 64-year 64-year JJ cord-010092-uftc8inx 8429 35 - - HYPH cord-010092-uftc8inx 8429 36 old old JJ cord-010092-uftc8inx 8429 37 patients patient NNS cord-010092-uftc8inx 8429 38 in in IN cord-010092-uftc8inx 8429 39 the the DT cord-010092-uftc8inx 8429 40 2018 2018 CD cord-010092-uftc8inx 8429 41 outbreak outbreak NN cord-010092-uftc8inx 8429 42 and and CC cord-010092-uftc8inx 8429 43 residents resident NNS cord-010092-uftc8inx 8429 44 of of IN cord-010092-uftc8inx 8429 45 the the DT cord-010092-uftc8inx 8429 46 same same JJ cord-010092-uftc8inx 8429 47 age age NN cord-010092-uftc8inx 8429 48 range range NN cord-010092-uftc8inx 8429 49 in in IN cord-010092-uftc8inx 8429 50 Hong Hong NNP cord-010092-uftc8inx 8429 51 Kong Kong NNP cord-010092-uftc8inx 8429 52 and and CC cord-010092-uftc8inx 8429 53 WTS WTS NNP cord-010092-uftc8inx 8429 54 District District NNP cord-010092-uftc8inx 8429 55 as as IN cord-010092-uftc8inx 8429 56 at at IN cord-010092-uftc8inx 8429 57 mid-2018 mid-2018 NN cord-010092-uftc8inx 8429 58 respectively respectively RB cord-010092-uftc8inx 8429 59 ( ( -LRB- cord-010092-uftc8inx 8429 60 16 16 CD cord-010092-uftc8inx 8429 61 - - SYM cord-010092-uftc8inx 8429 62 65 65 CD cord-010092-uftc8inx 8429 63 years year NNS cord-010092-uftc8inx 8429 64 old old JJ cord-010092-uftc8inx 8429 65 being be VBG cord-010092-uftc8inx 8429 66 the the DT cord-010092-uftc8inx 8429 67 eligible eligible JJ cord-010092-uftc8inx 8429 68 age age NN cord-010092-uftc8inx 8429 69 range range NN cord-010092-uftc8inx 8429 70 for for IN cord-010092-uftc8inx 8429 71 first first JJ cord-010092-uftc8inx 8429 72 time time NN cord-010092-uftc8inx 8429 73 donation donation NN cord-010092-uftc8inx 8429 74 ) ) -RRB- cord-010092-uftc8inx 8429 75 . . . cord-010092-uftc8inx 8430 1 To to TO cord-010092-uftc8inx 8430 2 apply apply VB cord-010092-uftc8inx 8430 3 the the DT cord-010092-uftc8inx 8430 4 B b NN cord-010092-uftc8inx 8430 5 - - HYPH cord-010092-uftc8inx 8430 6 P p NN cord-010092-uftc8inx 8430 7 model model NN cord-010092-uftc8inx 8430 8 , , , cord-010092-uftc8inx 8430 9 we -PRON- PRP cord-010092-uftc8inx 8430 10 estimated estimate VBD cord-010092-uftc8inx 8430 11 DENV DENV NNP cord-010092-uftc8inx 8430 12 incidence incidence NN cord-010092-uftc8inx 8430 13 among among IN cord-010092-uftc8inx 8430 14 donors donor NNS cord-010092-uftc8inx 8430 15 in in IN cord-010092-uftc8inx 8430 16 Hong Hong NNP cord-010092-uftc8inx 8430 17 Kong Kong NNP cord-010092-uftc8inx 8430 18 territory territory NN cord-010092-uftc8inx 8430 19 and and CC cord-010092-uftc8inx 8430 20 in in IN cord-010092-uftc8inx 8430 21 WTS WTS NNP cord-010092-uftc8inx 8430 22 with with IN cord-010092-uftc8inx 8430 23 confirmed confirm VBN cord-010092-uftc8inx 8430 24 DENV DENV NNP cord-010092-uftc8inx 8430 25 infection infection NN cord-010092-uftc8inx 8430 26 during during IN cord-010092-uftc8inx 8430 27 12 12 CD cord-010092-uftc8inx 8430 28 August August NNP cord-010092-uftc8inx 8430 29 to to IN cord-010092-uftc8inx 8430 30 8 8 CD cord-010092-uftc8inx 8430 31 September September NNP cord-010092-uftc8inx 8430 32 2018 2018 CD cord-010092-uftc8inx 8430 33 after after IN cord-010092-uftc8inx 8430 34 correction correction NN cord-010092-uftc8inx 8430 35 for for IN cord-010092-uftc8inx 8430 36 clinical clinical JJ cord-010092-uftc8inx 8430 37 : : : cord-010092-uftc8inx 8430 38 subclinical subclinical JJ cord-010092-uftc8inx 8430 39 infections infection NNS cord-010092-uftc8inx 8430 40 ratio ratio NN cord-010092-uftc8inx 8430 41 , , , cord-010092-uftc8inx 8430 42 the the DT cord-010092-uftc8inx 8430 43 mean mean JJ cord-010092-uftc8inx 8430 44 length length NN cord-010092-uftc8inx 8430 45 of of IN cord-010092-uftc8inx 8430 46 asymptomatic asymptomatic JJ cord-010092-uftc8inx 8430 47 viraemia viraemia NN cord-010092-uftc8inx 8430 48 and and CC cord-010092-uftc8inx 8430 49 the the DT cord-010092-uftc8inx 8430 50 probability probability NN cord-010092-uftc8inx 8430 51 of of IN cord-010092-uftc8inx 8430 52 collecting collect VBG cord-010092-uftc8inx 8430 53 blood blood NN cord-010092-uftc8inx 8430 54 from from IN cord-010092-uftc8inx 8430 55 asymptomatic asymptomatic JJ cord-010092-uftc8inx 8430 56 donors donor NNS cord-010092-uftc8inx 8430 57 as as IN cord-010092-uftc8inx 8430 58 described describe VBN cord-010092-uftc8inx 8430 59 previously previously RB cord-010092-uftc8inx 8430 60 ( ( -LRB- cord-010092-uftc8inx 8430 61 Seed Seed NNP cord-010092-uftc8inx 8430 62 , , , cord-010092-uftc8inx 8430 63 Transfusion Transfusion NNP cord-010092-uftc8inx 8430 64 , , , cord-010092-uftc8inx 8430 65 2009 2009 CD cord-010092-uftc8inx 8430 66 ) ) -RRB- cord-010092-uftc8inx 8430 67 . . . cord-010092-uftc8inx 8431 1 To to TO cord-010092-uftc8inx 8431 2 estimate estimate VB cord-010092-uftc8inx 8431 3 the the DT cord-010092-uftc8inx 8431 4 risk risk NN cord-010092-uftc8inx 8431 5 using use VBG cord-010092-uftc8inx 8431 6 EUFRAT EUFRAT NNP cord-010092-uftc8inx 8431 7 model model NN cord-010092-uftc8inx 8431 8 , , , cord-010092-uftc8inx 8431 9 outbreak outbreak NN cord-010092-uftc8inx 8431 10 and and CC cord-010092-uftc8inx 8431 11 blood blood NN cord-010092-uftc8inx 8431 12 donation donation NN cord-010092-uftc8inx 8431 13 variables variable NNS cord-010092-uftc8inx 8431 14 were be VBD cord-010092-uftc8inx 8431 15 entered enter VBN cord-010092-uftc8inx 8431 16 into into IN cord-010092-uftc8inx 8431 17 EUFRAT EUFRAT NNP cord-010092-uftc8inx 8431 18 's 's POS cord-010092-uftc8inx 8431 19 web web NN cord-010092-uftc8inx 8431 20 - - HYPH cord-010092-uftc8inx 8431 21 based base VBN cord-010092-uftc8inx 8431 22 interface interface NN cord-010092-uftc8inx 8431 23 ( ( -LRB- cord-010092-uftc8inx 8431 24 https://eufrattool.ecdc.europa.eu/ https://eufrattool.ecdc.europa.eu/ NNP cord-010092-uftc8inx 8431 25 ) ) -RRB- cord-010092-uftc8inx 8431 26 , , , cord-010092-uftc8inx 8431 27 which which WDT cord-010092-uftc8inx 8431 28 provided provide VBD cord-010092-uftc8inx 8431 29 automatic automatic JJ cord-010092-uftc8inx 8431 30 calculation calculation NN cord-010092-uftc8inx 8431 31 of of IN cord-010092-uftc8inx 8431 32 risk risk NN cord-010092-uftc8inx 8431 33 - - HYPH cord-010092-uftc8inx 8431 34 related relate VBN cord-010092-uftc8inx 8431 35 output output NN cord-010092-uftc8inx 8431 36 parameters parameter NNS cord-010092-uftc8inx 8431 37 . . . cord-010092-uftc8inx 8432 1 Results result NNS cord-010092-uftc8inx 8432 2 : : : cord-010092-uftc8inx 8433 1 While while IN cord-010092-uftc8inx 8433 2 using use VBG cord-010092-uftc8inx 8433 3 the the DT cord-010092-uftc8inx 8433 4 B B NNP cord-010092-uftc8inx 8433 5 - - HYPH cord-010092-uftc8inx 8433 6 P p NN cord-010092-uftc8inx 8433 7 model model NN cord-010092-uftc8inx 8433 8 , , , cord-010092-uftc8inx 8433 9 the the DT cord-010092-uftc8inx 8433 10 estimated estimate VBN cord-010092-uftc8inx 8433 11 risk risk NN cord-010092-uftc8inx 8433 12 of of IN cord-010092-uftc8inx 8433 13 collecting collect VBG cord-010092-uftc8inx 8433 14 a a DT cord-010092-uftc8inx 8433 15 DENV DENV NNP cord-010092-uftc8inx 8433 16 viraemic viraemic NN cord-010092-uftc8inx 8433 17 donation donation NN cord-010092-uftc8inx 8433 18 was be VBD cord-010092-uftc8inx 8433 19 one one CD cord-010092-uftc8inx 8433 20 in in IN cord-010092-uftc8inx 8433 21 778,000 778,000 CD cord-010092-uftc8inx 8433 22 ( ( -LRB- cord-010092-uftc8inx 8433 23 266,000 266,000 CD cord-010092-uftc8inx 8433 24 - - SYM cord-010092-uftc8inx 8433 25 1,822,000 1,822,000 CD cord-010092-uftc8inx 8433 26 ) ) -RRB- cord-010092-uftc8inx 8433 27 territory territory NN cord-010092-uftc8inx 8433 28 - - HYPH cord-010092-uftc8inx 8433 29 wide wide RB cord-010092-uftc8inx 8433 30 for for IN cord-010092-uftc8inx 8433 31 the the DT cord-010092-uftc8inx 8433 32 28-day 28-day CD cord-010092-uftc8inx 8433 33 study study NN cord-010092-uftc8inx 8433 34 period period NN cord-010092-uftc8inx 8433 35 but but CC cord-010092-uftc8inx 8433 36 increased increase VBD cord-010092-uftc8inx 8433 37 to to IN cord-010092-uftc8inx 8433 38 one one CD cord-010092-uftc8inx 8433 39 in in IN cord-010092-uftc8inx 8433 40 147,000 147,000 CD cord-010092-uftc8inx 8433 41 ( ( -LRB- cord-010092-uftc8inx 8433 42 50,000 50,000 CD cord-010092-uftc8inx 8433 43 - - SYM cord-010092-uftc8inx 8433 44 345,000 345,000 CD cord-010092-uftc8inx 8433 45 ) ) -RRB- cord-010092-uftc8inx 8433 46 in in IN cord-010092-uftc8inx 8433 47 WTS WTS NNP cord-010092-uftc8inx 8433 48 . . . cord-010092-uftc8inx 8434 1 Similarly similarly RB cord-010092-uftc8inx 8434 2 while while IN cord-010092-uftc8inx 8434 3 applying apply VBG cord-010092-uftc8inx 8434 4 the the DT cord-010092-uftc8inx 8434 5 EUFRAT EUFRAT NNP cord-010092-uftc8inx 8434 6 model model NN cord-010092-uftc8inx 8434 7 , , , cord-010092-uftc8inx 8434 8 the the DT cord-010092-uftc8inx 8434 9 risk risk NN cord-010092-uftc8inx 8434 10 of of IN cord-010092-uftc8inx 8434 11 encountering encounter VBG cord-010092-uftc8inx 8434 12 a a DT cord-010092-uftc8inx 8434 13 viraemic viraemic NN cord-010092-uftc8inx 8434 14 donor donor NN cord-010092-uftc8inx 8434 15 was be VBD cord-010092-uftc8inx 8434 16 1 1 CD cord-010092-uftc8inx 8434 17 in in IN cord-010092-uftc8inx 8434 18 279,000 279,000 CD cord-010092-uftc8inx 8434 19 ( ( -LRB- cord-010092-uftc8inx 8434 20 118,000 118,000 CD cord-010092-uftc8inx 8434 21 - - SYM cord-010092-uftc8inx 8434 22 752,000 752,000 CD cord-010092-uftc8inx 8434 23 ) ) -RRB- cord-010092-uftc8inx 8434 24 territory territory NN cord-010092-uftc8inx 8434 25 - - HYPH cord-010092-uftc8inx 8434 26 wide wide JJ cord-010092-uftc8inx 8434 27 and and CC cord-010092-uftc8inx 8434 28 1 1 CD cord-010092-uftc8inx 8434 29 in in IN cord-010092-uftc8inx 8434 30 52,000 52,000 CD cord-010092-uftc8inx 8434 31 ( ( -LRB- cord-010092-uftc8inx 8434 32 21,000 21,000 CD cord-010092-uftc8inx 8434 33 - - SYM cord-010092-uftc8inx 8434 34 188,000 188,000 CD cord-010092-uftc8inx 8434 35 ) ) -RRB- cord-010092-uftc8inx 8434 36 in in IN cord-010092-uftc8inx 8434 37 WTS WTS NNP cord-010092-uftc8inx 8434 38 during during IN cord-010092-uftc8inx 8434 39 the the DT cord-010092-uftc8inx 8434 40 same same JJ cord-010092-uftc8inx 8434 41 period period NN cord-010092-uftc8inx 8434 42 . . . cord-010092-uftc8inx 8435 1 The the DT cord-010092-uftc8inx 8435 2 EUFRAT EUFRAT NNP cord-010092-uftc8inx 8435 3 also also RB cord-010092-uftc8inx 8435 4 predicted predict VBD cord-010092-uftc8inx 8435 5 a a DT cord-010092-uftc8inx 8435 6 territory territory NN cord-010092-uftc8inx 8435 7 - - HYPH cord-010092-uftc8inx 8435 8 wide wide JJ cord-010092-uftc8inx 8435 9 issue issue NN cord-010092-uftc8inx 8435 10 of of IN cord-010092-uftc8inx 8435 11 0.08 0.08 CD cord-010092-uftc8inx 8435 12 unit unit NN cord-010092-uftc8inx 8435 13 of of IN cord-010092-uftc8inx 8435 14 DENV DENV NNP cord-010092-uftc8inx 8435 15 - - HYPH cord-010092-uftc8inx 8435 16 contaminated contaminate VBN cord-010092-uftc8inx 8435 17 labile labile JJ cord-010092-uftc8inx 8435 18 blood blood NN cord-010092-uftc8inx 8435 19 component component NN cord-010092-uftc8inx 8435 20 during during IN cord-010092-uftc8inx 8435 21 the the DT cord-010092-uftc8inx 8435 22 outbreak outbreak NN cord-010092-uftc8inx 8435 23 period period NN cord-010092-uftc8inx 8435 24 . . . cord-010092-uftc8inx 8436 1 Summary Summary NNP cord-010092-uftc8inx 8436 2 / / SYM cord-010092-uftc8inx 8436 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 8436 4 : : : cord-010092-uftc8inx 8437 1 Like like IN cord-010092-uftc8inx 8437 2 many many JJ cord-010092-uftc8inx 8437 3 mosquito mosquito NN cord-010092-uftc8inx 8437 4 - - HYPH cord-010092-uftc8inx 8437 5 borne bear VBN cord-010092-uftc8inx 8437 6 infections infection NNS cord-010092-uftc8inx 8437 7 such such JJ cord-010092-uftc8inx 8437 8 as as IN cord-010092-uftc8inx 8437 9 DENV DENV NNP cord-010092-uftc8inx 8437 10 , , , cord-010092-uftc8inx 8437 11 the the DT cord-010092-uftc8inx 8437 12 risk risk NN cord-010092-uftc8inx 8437 13 is be VBZ cord-010092-uftc8inx 8437 14 characteristically characteristically RB cord-010092-uftc8inx 8437 15 localised localise VBN cord-010092-uftc8inx 8437 16 and and CC cord-010092-uftc8inx 8437 17 varies vary VBZ cord-010092-uftc8inx 8437 18 geographically geographically RB cord-010092-uftc8inx 8437 19 and and CC cord-010092-uftc8inx 8437 20 seasonally seasonally RB cord-010092-uftc8inx 8437 21 during during IN cord-010092-uftc8inx 8437 22 outbreaks outbreak NNS cord-010092-uftc8inx 8437 23 . . . cord-010092-uftc8inx 8438 1 The the DT cord-010092-uftc8inx 8438 2 average average JJ cord-010092-uftc8inx 8438 3 predicted predict VBD cord-010092-uftc8inx 8438 4 risk risk NN cord-010092-uftc8inx 8438 5 of of IN cord-010092-uftc8inx 8438 6 collecting collect VBG cord-010092-uftc8inx 8438 7 a a DT cord-010092-uftc8inx 8438 8 DENV DENV NNP cord-010092-uftc8inx 8438 9 - - HYPH cord-010092-uftc8inx 8438 10 viraemic viraemic NN cord-010092-uftc8inx 8438 11 donation donation NN cord-010092-uftc8inx 8438 12 territory territory NN cord-010092-uftc8inx 8438 13 - - HYPH cord-010092-uftc8inx 8438 14 wide wide RB cord-010092-uftc8inx 8438 15 is be VBZ cord-010092-uftc8inx 8438 16 low low JJ cord-010092-uftc8inx 8438 17 at at IN cord-010092-uftc8inx 8438 18 1 1 CD cord-010092-uftc8inx 8438 19 in in IN cord-010092-uftc8inx 8438 20 778,000 778,000 CD cord-010092-uftc8inx 8438 21 during during IN cord-010092-uftc8inx 8438 22 the the DT cord-010092-uftc8inx 8438 23 2018 2018 CD cord-010092-uftc8inx 8438 24 outbreak outbreak NN cord-010092-uftc8inx 8438 25 based base VBN cord-010092-uftc8inx 8438 26 on on IN cord-010092-uftc8inx 8438 27 the the DT cord-010092-uftc8inx 8438 28 B b NN cord-010092-uftc8inx 8438 29 - - HYPH cord-010092-uftc8inx 8438 30 P p NN cord-010092-uftc8inx 8438 31 model model NN cord-010092-uftc8inx 8438 32 , , , cord-010092-uftc8inx 8438 33 which which WDT cord-010092-uftc8inx 8438 34 was be VBD cord-010092-uftc8inx 8438 35 generally generally RB cord-010092-uftc8inx 8438 36 considered consider VBN cord-010092-uftc8inx 8438 37 as as RB cord-010092-uftc8inx 8438 38 tolerable tolerable JJ cord-010092-uftc8inx 8438 39 . . . cord-010092-uftc8inx 8439 1 However however RB cord-010092-uftc8inx 8439 2 , , , cord-010092-uftc8inx 8439 3 the the DT cord-010092-uftc8inx 8439 4 risk risk NN cord-010092-uftc8inx 8439 5 increased increase VBD cord-010092-uftc8inx 8439 6 by by IN cord-010092-uftc8inx 8439 7 4 4 CD cord-010092-uftc8inx 8439 8 folds fold NNS cord-010092-uftc8inx 8439 9 when when WRB cord-010092-uftc8inx 8439 10 blood blood NN cord-010092-uftc8inx 8439 11 donations donation NNS cord-010092-uftc8inx 8439 12 were be VBD cord-010092-uftc8inx 8439 13 collected collect VBN cord-010092-uftc8inx 8439 14 from from IN cord-010092-uftc8inx 8439 15 WTS WTS NNP cord-010092-uftc8inx 8439 16 residents resident NNS cord-010092-uftc8inx 8439 17 , , , cord-010092-uftc8inx 8439 18 who who WP cord-010092-uftc8inx 8439 19 had have VBD cord-010092-uftc8inx 8439 20 higher high JJR cord-010092-uftc8inx 8439 21 chances chance NNS cord-010092-uftc8inx 8439 22 of of IN cord-010092-uftc8inx 8439 23 paying pay VBG cord-010092-uftc8inx 8439 24 visits visit NNS cord-010092-uftc8inx 8439 25 to to IN cord-010092-uftc8inx 8439 26 Lion Lion NNP cord-010092-uftc8inx 8439 27 Rock Rock NNP cord-010092-uftc8inx 8439 28 Park Park NNP cord-010092-uftc8inx 8439 29 in in IN cord-010092-uftc8inx 8439 30 close close JJ cord-010092-uftc8inx 8439 31 proximity proximity NN cord-010092-uftc8inx 8439 32 . . . cord-010092-uftc8inx 8440 1 It -PRON- PRP cord-010092-uftc8inx 8440 2 was be VBD cord-010092-uftc8inx 8440 3 then then RB cord-010092-uftc8inx 8440 4 justifiable justifiable JJ cord-010092-uftc8inx 8440 5 to to TO cord-010092-uftc8inx 8440 6 institute institute VB cord-010092-uftc8inx 8440 7 risk risk NN cord-010092-uftc8inx 8440 8 mitigation mitigation NN cord-010092-uftc8inx 8440 9 policies policy NNS cord-010092-uftc8inx 8440 10 such such JJ cord-010092-uftc8inx 8440 11 as as IN cord-010092-uftc8inx 8440 12 geographically geographically RB cord-010092-uftc8inx 8440 13 - - HYPH cord-010092-uftc8inx 8440 14 based base VBN cord-010092-uftc8inx 8440 15 deferral deferral NN cord-010092-uftc8inx 8441 1 and/or and/or CC cord-010092-uftc8inx 8441 2 fresh fresh JJ cord-010092-uftc8inx 8441 3 component component NN cord-010092-uftc8inx 8441 4 restriction restriction NN cord-010092-uftc8inx 8441 5 , , , cord-010092-uftc8inx 8441 6 enhanced enhance VBN cord-010092-uftc8inx 8441 7 post post JJ cord-010092-uftc8inx 8441 8 - - JJ cord-010092-uftc8inx 8441 9 donation donation NN cord-010092-uftc8inx 8441 10 reporting reporting NN cord-010092-uftc8inx 8441 11 , , , cord-010092-uftc8inx 8441 12 etc etc FW cord-010092-uftc8inx 8441 13 . . . cord-010092-uftc8inx 8442 1 to to TO cord-010092-uftc8inx 8442 2 protect protect VB cord-010092-uftc8inx 8442 3 against against IN cord-010092-uftc8inx 8442 4 blood blood NN cord-010092-uftc8inx 8442 5 safety safety NN cord-010092-uftc8inx 8442 6 . . . cord-010092-uftc8inx 8443 1 Background background NN cord-010092-uftc8inx 8443 2 : : : cord-010092-uftc8inx 8444 1 HEV HEV NNP cord-010092-uftc8inx 8444 2 is be VBZ cord-010092-uftc8inx 8444 3 a a DT cord-010092-uftc8inx 8444 4 developing develop VBG cord-010092-uftc8inx 8444 5 threat threat NN cord-010092-uftc8inx 8444 6 to to IN cord-010092-uftc8inx 8444 7 blood blood NN cord-010092-uftc8inx 8444 8 safety safety NN cord-010092-uftc8inx 8444 9 following follow VBG cord-010092-uftc8inx 8444 10 the the DT cord-010092-uftc8inx 8444 11 reporting reporting NN cord-010092-uftc8inx 8444 12 of of IN cord-010092-uftc8inx 8444 13 several several JJ cord-010092-uftc8inx 8444 14 cases case NNS cord-010092-uftc8inx 8444 15 of of IN cord-010092-uftc8inx 8444 16 transfusion transfusion NN cord-010092-uftc8inx 8444 17 transmission transmission NN cord-010092-uftc8inx 8444 18 HEV hev NN cord-010092-uftc8inx 8444 19 ( ( -LRB- cord-010092-uftc8inx 8444 20 TT TT NNP cord-010092-uftc8inx 8444 21 - - HYPH cord-010092-uftc8inx 8444 22 HEV HEV NNP cord-010092-uftc8inx 8444 23 ) ) -RRB- cord-010092-uftc8inx 8444 24 . . . cord-010092-uftc8inx 8445 1 Transfusion transfusion NN cord-010092-uftc8inx 8445 2 - - HYPH cord-010092-uftc8inx 8445 3 related relate VBN cord-010092-uftc8inx 8445 4 HEV hev NN cord-010092-uftc8inx 8445 5 infection infection NN cord-010092-uftc8inx 8445 6 has have VBZ cord-010092-uftc8inx 8445 7 been be VBN cord-010092-uftc8inx 8445 8 reported report VBN cord-010092-uftc8inx 8445 9 in in IN cord-010092-uftc8inx 8445 10 several several JJ cord-010092-uftc8inx 8445 11 countries country NNS cord-010092-uftc8inx 8445 12 but but CC cord-010092-uftc8inx 8445 13 its -PRON- PRP$ cord-010092-uftc8inx 8445 14 true true JJ cord-010092-uftc8inx 8445 15 frequency frequency NN cord-010092-uftc8inx 8445 16 is be VBZ cord-010092-uftc8inx 8445 17 probably probably RB cord-010092-uftc8inx 8445 18 underestimated underestimate VBN cord-010092-uftc8inx 8445 19 because because IN cord-010092-uftc8inx 8445 20 it -PRON- PRP cord-010092-uftc8inx 8445 21 is be VBZ cord-010092-uftc8inx 8445 22 often often RB cord-010092-uftc8inx 8445 23 asymptomatic asymptomatic JJ cord-010092-uftc8inx 8445 24 and and CC cord-010092-uftc8inx 8445 25 testing testing NN cord-010092-uftc8inx 8445 26 of of IN cord-010092-uftc8inx 8445 27 blood blood NN cord-010092-uftc8inx 8445 28 donors donor NNS cord-010092-uftc8inx 8445 29 is be VBZ cord-010092-uftc8inx 8445 30 infrequent infrequent JJ cord-010092-uftc8inx 8445 31 . . . cord-010092-uftc8inx 8446 1 Pakistan Pakistan NNP cord-010092-uftc8inx 8446 2 is be VBZ cord-010092-uftc8inx 8446 3 classified classify VBN cord-010092-uftc8inx 8446 4 as as IN cord-010092-uftc8inx 8446 5 a a DT cord-010092-uftc8inx 8446 6 highly highly RB cord-010092-uftc8inx 8446 7 endemic endemic JJ cord-010092-uftc8inx 8446 8 region region NN cord-010092-uftc8inx 8446 9 ; ; : cord-010092-uftc8inx 8446 10 with with IN cord-010092-uftc8inx 8446 11 sporadic sporadic JJ cord-010092-uftc8inx 8446 12 cases case NNS cord-010092-uftc8inx 8446 13 of of IN cord-010092-uftc8inx 8446 14 HEV hev NN cord-010092-uftc8inx 8446 15 occurring occur VBG cord-010092-uftc8inx 8446 16 throughout throughout IN cord-010092-uftc8inx 8446 17 the the DT cord-010092-uftc8inx 8446 18 year year NN cord-010092-uftc8inx 8446 19 , , , cord-010092-uftc8inx 8446 20 mainly mainly RB cord-010092-uftc8inx 8446 21 affecting affect VBG cord-010092-uftc8inx 8446 22 the the DT cord-010092-uftc8inx 8446 23 adult adult NN cord-010092-uftc8inx 8446 24 population population NN cord-010092-uftc8inx 8446 25 . . . cord-010092-uftc8inx 8447 1 To to IN cord-010092-uftc8inx 8447 2 the the DT cord-010092-uftc8inx 8447 3 best good JJS cord-010092-uftc8inx 8447 4 of of IN cord-010092-uftc8inx 8447 5 our -PRON- PRP$ cord-010092-uftc8inx 8447 6 knowledge knowledge NN cord-010092-uftc8inx 8447 7 , , , cord-010092-uftc8inx 8447 8 no no DT cord-010092-uftc8inx 8447 9 studies study NNS cord-010092-uftc8inx 8447 10 have have VBP cord-010092-uftc8inx 8447 11 been be VBN cord-010092-uftc8inx 8447 12 reported report VBN cord-010092-uftc8inx 8447 13 from from IN cord-010092-uftc8inx 8447 14 Pakistan Pakistan NNP cord-010092-uftc8inx 8447 15 on on IN cord-010092-uftc8inx 8447 16 the the DT cord-010092-uftc8inx 8447 17 epidemiology epidemiology NN cord-010092-uftc8inx 8447 18 of of IN cord-010092-uftc8inx 8447 19 HEV hev NN cord-010092-uftc8inx 8447 20 in in IN cord-010092-uftc8inx 8447 21 blood blood NN cord-010092-uftc8inx 8447 22 donors donor NNS cord-010092-uftc8inx 8447 23 . . . cord-010092-uftc8inx 8448 1 Aims aim VBZ cord-010092-uftc8inx 8448 2 : : : cord-010092-uftc8inx 8449 1 To to TO cord-010092-uftc8inx 8449 2 assess assess VB cord-010092-uftc8inx 8449 3 the the DT cord-010092-uftc8inx 8449 4 epidemiology epidemiology NN cord-010092-uftc8inx 8449 5 of of IN cord-010092-uftc8inx 8449 6 the the DT cord-010092-uftc8inx 8449 7 HEV HEV NNP cord-010092-uftc8inx 8449 8 specific specific JJ cord-010092-uftc8inx 8449 9 antibodies antibody NNS cord-010092-uftc8inx 8449 10 and and CC cord-010092-uftc8inx 8449 11 serum serum NN cord-010092-uftc8inx 8449 12 ALT alt NN cord-010092-uftc8inx 8449 13 levels level NNS cord-010092-uftc8inx 8449 14 in in IN cord-010092-uftc8inx 8449 15 Blood Blood NNP cord-010092-uftc8inx 8449 16 Donors Donors NNPS cord-010092-uftc8inx 8449 17 of of IN cord-010092-uftc8inx 8449 18 Capital Capital NNP cord-010092-uftc8inx 8449 19 twin twin JJ cord-010092-uftc8inx 8449 20 cities city NNS cord-010092-uftc8inx 8449 21 of of IN cord-010092-uftc8inx 8449 22 Pakistan Pakistan NNP cord-010092-uftc8inx 8449 23 . . . cord-010092-uftc8inx 8450 1 Methods method NNS cord-010092-uftc8inx 8450 2 : : : cord-010092-uftc8inx 8451 1 This this DT cord-010092-uftc8inx 8451 2 cross cross JJ cord-010092-uftc8inx 8451 3 sectional sectional JJ cord-010092-uftc8inx 8451 4 study study NN cord-010092-uftc8inx 8451 5 was be VBD cord-010092-uftc8inx 8451 6 conducted conduct VBN cord-010092-uftc8inx 8451 7 from from IN cord-010092-uftc8inx 8451 8 July July NNP cord-010092-uftc8inx 8451 9 2017 2017 CD cord-010092-uftc8inx 8451 10 to to IN cord-010092-uftc8inx 8451 11 December December NNP cord-010092-uftc8inx 8451 12 2017 2017 CD cord-010092-uftc8inx 8451 13 at at IN cord-010092-uftc8inx 8451 14 three three CD cord-010092-uftc8inx 8451 15 blood blood NN cord-010092-uftc8inx 8451 16 banks bank NNS cord-010092-uftc8inx 8451 17 in in IN cord-010092-uftc8inx 8451 18 the the DT cord-010092-uftc8inx 8451 19 capital capital NN cord-010092-uftc8inx 8451 20 twin twin JJ cord-010092-uftc8inx 8451 21 cities city NNS cord-010092-uftc8inx 8451 22 ( ( -LRB- cord-010092-uftc8inx 8451 23 Rawalpindi Rawalpindi NNP cord-010092-uftc8inx 8451 24 and and CC cord-010092-uftc8inx 8451 25 Islamabad Islamabad NNP cord-010092-uftc8inx 8451 26 ) ) -RRB- cord-010092-uftc8inx 8451 27 of of IN cord-010092-uftc8inx 8451 28 Pakistan Pakistan NNP cord-010092-uftc8inx 8451 29 . . . cord-010092-uftc8inx 8452 1 The the DT cord-010092-uftc8inx 8452 2 blood blood NN cord-010092-uftc8inx 8452 3 donors donor NNS cord-010092-uftc8inx 8452 4 were be VBD cord-010092-uftc8inx 8452 5 equally equally RB cord-010092-uftc8inx 8452 6 distributed distribute VBN cord-010092-uftc8inx 8452 7 across across IN cord-010092-uftc8inx 8452 8 the the DT cord-010092-uftc8inx 8452 9 three three CD cord-010092-uftc8inx 8452 10 blood blood NN cord-010092-uftc8inx 8452 11 banks bank NNS cord-010092-uftc8inx 8452 12 . . . cord-010092-uftc8inx 8453 1 Only only JJ cord-010092-uftc8inx 8453 2 donors donor NNS cord-010092-uftc8inx 8453 3 who who WP cord-010092-uftc8inx 8453 4 tested test VBD cord-010092-uftc8inx 8453 5 negative negative JJ cord-010092-uftc8inx 8453 6 for for IN cord-010092-uftc8inx 8453 7 HIV HIV NNP cord-010092-uftc8inx 8453 8 , , , cord-010092-uftc8inx 8453 9 HBV HBV NNP cord-010092-uftc8inx 8453 10 and and CC cord-010092-uftc8inx 8453 11 HCV HCV NNP cord-010092-uftc8inx 8453 12 were be VBD cord-010092-uftc8inx 8453 13 included include VBN cord-010092-uftc8inx 8453 14 in in IN cord-010092-uftc8inx 8453 15 the the DT cord-010092-uftc8inx 8453 16 study study NN cord-010092-uftc8inx 8453 17 . . . cord-010092-uftc8inx 8454 1 Serum serum NN cord-010092-uftc8inx 8454 2 ALT alt NN cord-010092-uftc8inx 8454 3 levels level NNS cord-010092-uftc8inx 8454 4 were be VBD cord-010092-uftc8inx 8454 5 analyzed analyze VBN cord-010092-uftc8inx 8454 6 by by IN cord-010092-uftc8inx 8454 7 using use VBG cord-010092-uftc8inx 8454 8 automated automate VBN cord-010092-uftc8inx 8454 9 clinical clinical JJ cord-010092-uftc8inx 8454 10 chemistry chemistry NN cord-010092-uftc8inx 8454 11 analyzer analyzer NN cord-010092-uftc8inx 8454 12 ( ( -LRB- cord-010092-uftc8inx 8454 13 SELCTRA SELCTRA NNP cord-010092-uftc8inx 8454 14 Pro Pro NNP cord-010092-uftc8inx 8454 15 M M NNP cord-010092-uftc8inx 8454 16 ) ) -RRB- cord-010092-uftc8inx 8454 17 using use VBG cord-010092-uftc8inx 8454 18 MERCK MERCK NNP cord-010092-uftc8inx 8454 19 kits kit NNS cord-010092-uftc8inx 8454 20 . . . cord-010092-uftc8inx 8455 1 All all DT cord-010092-uftc8inx 8455 2 samples sample NNS cord-010092-uftc8inx 8455 3 were be VBD cord-010092-uftc8inx 8455 4 tested test VBN cord-010092-uftc8inx 8455 5 for for IN cord-010092-uftc8inx 8455 6 HEV hev NN cord-010092-uftc8inx 8455 7 - - HYPH cord-010092-uftc8inx 8455 8 specific specific JJ cord-010092-uftc8inx 8455 9 antibodies antibody NNS cord-010092-uftc8inx 8455 10 ( ( -LRB- cord-010092-uftc8inx 8455 11 IgM IgM NNP cord-010092-uftc8inx 8455 12 and and CC cord-010092-uftc8inx 8455 13 IgG IgG NNP cord-010092-uftc8inx 8455 14 ) ) -RRB- cord-010092-uftc8inx 8455 15 by by IN cord-010092-uftc8inx 8455 16 using use VBG cord-010092-uftc8inx 8455 17 Enzyme Enzyme NNP cord-010092-uftc8inx 8455 18 linked link VBN cord-010092-uftc8inx 8455 19 immunosorbent immunosorbent JJ cord-010092-uftc8inx 8455 20 assay assay NN cord-010092-uftc8inx 8455 21 ( ( -LRB- cord-010092-uftc8inx 8455 22 ELISA ELISA NNP cord-010092-uftc8inx 8455 23 ) ) -RRB- cord-010092-uftc8inx 8455 24 kits kit NNS cord-010092-uftc8inx 8455 25 ( ( -LRB- cord-010092-uftc8inx 8455 26 Adaltis Adaltis NNP cord-010092-uftc8inx 8455 27 , , , cord-010092-uftc8inx 8455 28 Italy Italy NNP cord-010092-uftc8inx 8455 29 ) ) -RRB- cord-010092-uftc8inx 8455 30 . . . cord-010092-uftc8inx 8456 1 Statistical statistical JJ cord-010092-uftc8inx 8456 2 analyses analysis NNS cord-010092-uftc8inx 8456 3 were be VBD cord-010092-uftc8inx 8456 4 performed perform VBN cord-010092-uftc8inx 8456 5 using use VBG cord-010092-uftc8inx 8456 6 SPSS SPSS NNP cord-010092-uftc8inx 8456 7 software software NN cord-010092-uftc8inx 8456 8 version version NN cord-010092-uftc8inx 8456 9 21.0 21.0 CD cord-010092-uftc8inx 8456 10 ( ( -LRB- cord-010092-uftc8inx 8456 11 IBM IBM NNP cord-010092-uftc8inx 8456 12 ) ) -RRB- cord-010092-uftc8inx 8456 13 . . . cord-010092-uftc8inx 8457 1 Results result NNS cord-010092-uftc8inx 8457 2 : : : cord-010092-uftc8inx 8458 1 In in IN cord-010092-uftc8inx 8458 2 our -PRON- PRP$ cord-010092-uftc8inx 8458 3 study study NN cord-010092-uftc8inx 8458 4 population population NN cord-010092-uftc8inx 8458 5 there there EX cord-010092-uftc8inx 8458 6 were be VBD cord-010092-uftc8inx 8458 7 445 445 CD cord-010092-uftc8inx 8458 8 ( ( -LRB- cord-010092-uftc8inx 8458 9 98.9 98.9 CD cord-010092-uftc8inx 8458 10 % % NN cord-010092-uftc8inx 8458 11 ) ) -RRB- cord-010092-uftc8inx 8458 12 males male NNS cord-010092-uftc8inx 8458 13 and and CC cord-010092-uftc8inx 8458 14 5 5 CD cord-010092-uftc8inx 8458 15 ( ( -LRB- cord-010092-uftc8inx 8458 16 1.1 1.1 CD cord-010092-uftc8inx 8458 17 % % NN cord-010092-uftc8inx 8458 18 ) ) -RRB- cord-010092-uftc8inx 8458 19 females female NNS cord-010092-uftc8inx 8458 20 . . . cord-010092-uftc8inx 8459 1 The the DT cord-010092-uftc8inx 8459 2 mean mean JJ cord-010092-uftc8inx 8459 3 age age NN cord-010092-uftc8inx 8459 4 of of IN cord-010092-uftc8inx 8459 5 recruited recruit VBN cord-010092-uftc8inx 8459 6 blood blood NN cord-010092-uftc8inx 8459 7 donors donor NNS cord-010092-uftc8inx 8459 8 was be VBD cord-010092-uftc8inx 8459 9 28.38 28.38 CD cord-010092-uftc8inx 8459 10 ( ( -LRB- cord-010092-uftc8inx 8459 11 SD SD NNP cord-010092-uftc8inx 8459 12 AE AE NNP cord-010092-uftc8inx 8459 13 7.34 7.34 CD cord-010092-uftc8inx 8459 14 ) ) -RRB- cord-010092-uftc8inx 8459 15 , , , cord-010092-uftc8inx 8459 16 with with IN cord-010092-uftc8inx 8459 17 a a DT cord-010092-uftc8inx 8459 18 range range NN cord-010092-uftc8inx 8459 19 of of IN cord-010092-uftc8inx 8459 20 18 18 CD cord-010092-uftc8inx 8459 21 - - SYM cord-010092-uftc8inx 8459 22 55 55 CD cord-010092-uftc8inx 8459 23 . . . cord-010092-uftc8inx 8460 1 Younger young JJR cord-010092-uftc8inx 8460 2 donors donor NNS cord-010092-uftc8inx 8460 3 were be VBD cord-010092-uftc8inx 8460 4 more more RBR cord-010092-uftc8inx 8460 5 common common JJ cord-010092-uftc8inx 8460 6 with with IN cord-010092-uftc8inx 8460 7 a a DT cord-010092-uftc8inx 8460 8 frequency frequency NN cord-010092-uftc8inx 8460 9 of of IN cord-010092-uftc8inx 8460 10 18 18 CD cord-010092-uftc8inx 8460 11 - - SYM cord-010092-uftc8inx 8460 12 27 27 CD cord-010092-uftc8inx 8460 13 year year NN cord-010092-uftc8inx 8460 14 olds old NNS cord-010092-uftc8inx 8460 15 of of IN cord-010092-uftc8inx 8460 16 249 249 CD cord-010092-uftc8inx 8460 17 ( ( -LRB- cord-010092-uftc8inx 8460 18 55.3 55.3 CD cord-010092-uftc8inx 8460 19 % % NN cord-010092-uftc8inx 8460 20 ) ) -RRB- cord-010092-uftc8inx 8460 21 . . . cord-010092-uftc8inx 8461 1 We -PRON- PRP cord-010092-uftc8inx 8461 2 found find VBD cord-010092-uftc8inx 8461 3 an an DT cord-010092-uftc8inx 8461 4 overall overall JJ cord-010092-uftc8inx 8461 5 HEV HEV NNP cord-010092-uftc8inx 8461 6 IgG igg NN cord-010092-uftc8inx 8461 7 prevalence prevalence NN cord-010092-uftc8inx 8461 8 of of IN cord-010092-uftc8inx 8461 9 17.5 17.5 CD cord-010092-uftc8inx 8461 10 % % NN cord-010092-uftc8inx 8461 11 and and CC cord-010092-uftc8inx 8461 12 an an DT cord-010092-uftc8inx 8461 13 HEV hev NN cord-010092-uftc8inx 8461 14 IgM igm NN cord-010092-uftc8inx 8461 15 prevalence prevalence NN cord-010092-uftc8inx 8461 16 of of IN cord-010092-uftc8inx 8461 17 9.1 9.1 CD cord-010092-uftc8inx 8461 18 % % NN cord-010092-uftc8inx 8461 19 . . . cord-010092-uftc8inx 8462 1 There there EX cord-010092-uftc8inx 8462 2 were be VBD cord-010092-uftc8inx 8462 3 10 10 CD cord-010092-uftc8inx 8462 4 ( ( -LRB- cord-010092-uftc8inx 8462 5 2.2 2.2 CD cord-010092-uftc8inx 8462 6 % % NN cord-010092-uftc8inx 8462 7 ) ) -RRB- cord-010092-uftc8inx 8462 8 blood blood NN cord-010092-uftc8inx 8462 9 donors donor NNS cord-010092-uftc8inx 8462 10 who who WP cord-010092-uftc8inx 8462 11 were be VBD cord-010092-uftc8inx 8462 12 positive positive JJ cord-010092-uftc8inx 8462 13 for for IN cord-010092-uftc8inx 8462 14 both both DT cord-010092-uftc8inx 8462 15 IgG IgG NNP cord-010092-uftc8inx 8462 16 and and CC cord-010092-uftc8inx 8462 17 IgM IgM NNP cord-010092-uftc8inx 8462 18 antibodies antibody NNS cord-010092-uftc8inx 8462 19 . . . cord-010092-uftc8inx 8463 1 Our -PRON- PRP$ cord-010092-uftc8inx 8463 2 results result NNS cord-010092-uftc8inx 8463 3 revealed reveal VBD cord-010092-uftc8inx 8463 4 that that IN cord-010092-uftc8inx 8463 5 the the DT cord-010092-uftc8inx 8463 6 HEV HEV NNP cord-010092-uftc8inx 8463 7 specific specific JJ cord-010092-uftc8inx 8463 8 antibodies antibody NNS cord-010092-uftc8inx 8463 9 ( ( -LRB- cord-010092-uftc8inx 8463 10 IgG IgG NNP cord-010092-uftc8inx 8463 11 , , , cord-010092-uftc8inx 8463 12 IgM IgM NNP cord-010092-uftc8inx 8463 13 ) ) -RRB- cord-010092-uftc8inx 8463 14 prevalence prevalence NN cord-010092-uftc8inx 8463 15 increased increase VBD cord-010092-uftc8inx 8463 16 with with IN cord-010092-uftc8inx 8463 17 age age NN cord-010092-uftc8inx 8463 18 . . . cord-010092-uftc8inx 8464 1 The the DT cord-010092-uftc8inx 8464 2 mean mean JJ cord-010092-uftc8inx 8464 3 value value NN cord-010092-uftc8inx 8464 4 of of IN cord-010092-uftc8inx 8464 5 serum serum NN cord-010092-uftc8inx 8464 6 ALT alt NN cord-010092-uftc8inx 8464 7 was be VBD cord-010092-uftc8inx 8464 8 33.8 33.8 CD cord-010092-uftc8inx 8464 9 ( ( -LRB- cord-010092-uftc8inx 8464 10 SD SD NNP cord-010092-uftc8inx 8464 11 AE AE NNP cord-010092-uftc8inx 8464 12 41.0 41.0 CD cord-010092-uftc8inx 8464 13 ) ) -RRB- cord-010092-uftc8inx 8464 14 with with IN cord-010092-uftc8inx 8464 15 a a DT cord-010092-uftc8inx 8464 16 range range NN cord-010092-uftc8inx 8464 17 of of IN cord-010092-uftc8inx 8464 18 4 4 CD cord-010092-uftc8inx 8464 19 - - SYM cord-010092-uftc8inx 8464 20 554 554 CD cord-010092-uftc8inx 8464 21 IU IU NNP cord-010092-uftc8inx 8464 22 / / SYM cord-010092-uftc8inx 8464 23 L. L. NNP cord-010092-uftc8inx 8465 1 The the DT cord-010092-uftc8inx 8465 2 serum serum NN cord-010092-uftc8inx 8465 3 ALT alt NN cord-010092-uftc8inx 8465 4 levels level NNS cord-010092-uftc8inx 8465 5 were be VBD cord-010092-uftc8inx 8465 6 elevated elevate VBN cord-010092-uftc8inx 8465 7 ( ( -LRB- cord-010092-uftc8inx 8465 8 > > NFP cord-010092-uftc8inx 8465 9 45 45 CD cord-010092-uftc8inx 8465 10 IU IU NNP cord-010092-uftc8inx 8465 11 / / SYM cord-010092-uftc8inx 8465 12 L L NNP cord-010092-uftc8inx 8465 13 ) ) -RRB- cord-010092-uftc8inx 8465 14 in in IN cord-010092-uftc8inx 8465 15 73 73 CD cord-010092-uftc8inx 8465 16 ( ( -LRB- cord-010092-uftc8inx 8465 17 16.3 16.3 CD cord-010092-uftc8inx 8465 18 % % NN cord-010092-uftc8inx 8465 19 ) ) -RRB- cord-010092-uftc8inx 8465 20 blood blood NN cord-010092-uftc8inx 8465 21 donors donor NNS cord-010092-uftc8inx 8465 22 . . . cord-010092-uftc8inx 8466 1 There there EX cord-010092-uftc8inx 8466 2 was be VBD cord-010092-uftc8inx 8466 3 significant significant JJ cord-010092-uftc8inx 8466 4 correlation correlation NN cord-010092-uftc8inx 8466 5 ( ( -LRB- cord-010092-uftc8inx 8466 6 P=<0.001 P=<0.001 NNP cord-010092-uftc8inx 8466 7 ) ) -RRB- cord-010092-uftc8inx 8466 8 between between IN cord-010092-uftc8inx 8466 9 serum serum NN cord-010092-uftc8inx 8466 10 ALT alt NN cord-010092-uftc8inx 8466 11 level level NN cord-010092-uftc8inx 8466 12 and and CC cord-010092-uftc8inx 8466 13 HEV hev VB cord-010092-uftc8inx 8466 14 specific specific JJ cord-010092-uftc8inx 8466 15 antibodies antibody NNS cord-010092-uftc8inx 8466 16 for for IN cord-010092-uftc8inx 8466 17 IgG igg NN cord-010092-uftc8inx 8466 18 and and CC cord-010092-uftc8inx 8466 19 IgM. IgM. NNP cord-010092-uftc8inx 8466 20 Summary Summary NNP cord-010092-uftc8inx 8466 21 / / SYM cord-010092-uftc8inx 8466 22 Conclusions Conclusions NNPS cord-010092-uftc8inx 8466 23 : : : cord-010092-uftc8inx 8467 1 This this DT cord-010092-uftc8inx 8467 2 study study NN cord-010092-uftc8inx 8467 3 shows show VBZ cord-010092-uftc8inx 8467 4 that that IN cord-010092-uftc8inx 8467 5 a a DT cord-010092-uftc8inx 8467 6 significant significant JJ cord-010092-uftc8inx 8467 7 proportion proportion NN cord-010092-uftc8inx 8467 8 of of IN cord-010092-uftc8inx 8467 9 blood blood NN cord-010092-uftc8inx 8467 10 donors donor NNS cord-010092-uftc8inx 8467 11 at at IN cord-010092-uftc8inx 8467 12 our -PRON- PRP$ cord-010092-uftc8inx 8467 13 blood blood NN cord-010092-uftc8inx 8467 14 centers center NNS cord-010092-uftc8inx 8467 15 have have VBP cord-010092-uftc8inx 8467 16 been be VBN cord-010092-uftc8inx 8467 17 infected infect VBN cord-010092-uftc8inx 8467 18 with with IN cord-010092-uftc8inx 8467 19 HEV HEV NNP cord-010092-uftc8inx 8467 20 and and CC cord-010092-uftc8inx 8467 21 may may MD cord-010092-uftc8inx 8467 22 be be VB cord-010092-uftc8inx 8467 23 able able JJ cord-010092-uftc8inx 8467 24 to to TO cord-010092-uftc8inx 8467 25 cause cause VB cord-010092-uftc8inx 8467 26 TT TT NNP cord-010092-uftc8inx 8467 27 - - HYPH cord-010092-uftc8inx 8467 28 HEV HEV NNP cord-010092-uftc8inx 8467 29 . . . cord-010092-uftc8inx 8468 1 As as IN cord-010092-uftc8inx 8468 2 we -PRON- PRP cord-010092-uftc8inx 8468 3 have have VBP cord-010092-uftc8inx 8468 4 not not RB cord-010092-uftc8inx 8468 5 yet yet RB cord-010092-uftc8inx 8468 6 measured measure VBN cord-010092-uftc8inx 8468 7 HEV HEV NNP cord-010092-uftc8inx 8468 8 RNA RNA NNP cord-010092-uftc8inx 8468 9 , , , cord-010092-uftc8inx 8468 10 we -PRON- PRP cord-010092-uftc8inx 8468 11 have have VBP cord-010092-uftc8inx 8468 12 used use VBN cord-010092-uftc8inx 8468 13 IgM IgM NNP cord-010092-uftc8inx 8468 14 antibodies antibody NNS cord-010092-uftc8inx 8468 15 as as IN cord-010092-uftc8inx 8468 16 a a DT cord-010092-uftc8inx 8468 17 proxy proxy NN cord-010092-uftc8inx 8468 18 for for IN cord-010092-uftc8inx 8468 19 donors donor NNS cord-010092-uftc8inx 8468 20 who who WP cord-010092-uftc8inx 8468 21 have have VBP cord-010092-uftc8inx 8468 22 active active JJ cord-010092-uftc8inx 8468 23 infection infection NN cord-010092-uftc8inx 8468 24 . . . cord-010092-uftc8inx 8469 1 HEV HEV NNP cord-010092-uftc8inx 8469 2 is be VBZ cord-010092-uftc8inx 8469 3 generally generally RB cord-010092-uftc8inx 8469 4 asymptomatic asymptomatic JJ cord-010092-uftc8inx 8469 5 , , , cord-010092-uftc8inx 8469 6 so so CC cord-010092-uftc8inx 8469 7 it -PRON- PRP cord-010092-uftc8inx 8469 8 is be VBZ cord-010092-uftc8inx 8469 9 debatable debatable JJ cord-010092-uftc8inx 8469 10 whether whether IN cord-010092-uftc8inx 8469 11 mandatory mandatory JJ cord-010092-uftc8inx 8469 12 HEV hev NN cord-010092-uftc8inx 8469 13 screening screening NN cord-010092-uftc8inx 8469 14 in in IN cord-010092-uftc8inx 8469 15 blood blood NN cord-010092-uftc8inx 8469 16 donors donor NNS cord-010092-uftc8inx 8469 17 should should MD cord-010092-uftc8inx 8469 18 be be VB cord-010092-uftc8inx 8469 19 required require VBN cord-010092-uftc8inx 8469 20 . . . cord-010092-uftc8inx 8470 1 Results result NNS cord-010092-uftc8inx 8470 2 of of IN cord-010092-uftc8inx 8470 3 this this DT cord-010092-uftc8inx 8470 4 pilot pilot NN cord-010092-uftc8inx 8470 5 study study NN cord-010092-uftc8inx 8470 6 show show VBP cord-010092-uftc8inx 8470 7 that that IN cord-010092-uftc8inx 8470 8 there there EX cord-010092-uftc8inx 8470 9 is be VBZ cord-010092-uftc8inx 8470 10 a a DT cord-010092-uftc8inx 8470 11 need need NN cord-010092-uftc8inx 8470 12 to to TO cord-010092-uftc8inx 8470 13 conduct conduct VB cord-010092-uftc8inx 8470 14 a a DT cord-010092-uftc8inx 8470 15 larger large JJR cord-010092-uftc8inx 8470 16 study study NN cord-010092-uftc8inx 8470 17 at at IN cord-010092-uftc8inx 8470 18 National national JJ cord-010092-uftc8inx 8470 19 level level NN cord-010092-uftc8inx 8470 20 with with IN cord-010092-uftc8inx 8470 21 highly highly RB cord-010092-uftc8inx 8470 22 sensitive sensitive JJ cord-010092-uftc8inx 8470 23 assays assay NNS cord-010092-uftc8inx 8470 24 before before IN cord-010092-uftc8inx 8470 25 making make VBG cord-010092-uftc8inx 8470 26 screening screening NN cord-010092-uftc8inx 8470 27 for for IN cord-010092-uftc8inx 8470 28 HEV HEV NNP cord-010092-uftc8inx 8470 29 mandatory mandatory NN cord-010092-uftc8inx 8470 30 in in IN cord-010092-uftc8inx 8470 31 Pakistan Pakistan NNP cord-010092-uftc8inx 8470 32 . . . cord-010092-uftc8inx 8471 1 Background background NN cord-010092-uftc8inx 8471 2 : : : cord-010092-uftc8inx 8472 1 Hepatitis hepatitis NN cord-010092-uftc8inx 8472 2 E e NN cord-010092-uftc8inx 8472 3 virus virus NN cord-010092-uftc8inx 8472 4 ( ( -LRB- cord-010092-uftc8inx 8472 5 HEV HEV NNP cord-010092-uftc8inx 8472 6 ) ) -RRB- cord-010092-uftc8inx 8472 7 is be VBZ cord-010092-uftc8inx 8472 8 a a DT cord-010092-uftc8inx 8472 9 zoonotic zoonotic JJ cord-010092-uftc8inx 8472 10 virus virus NN cord-010092-uftc8inx 8472 11 . . . cord-010092-uftc8inx 8473 1 WHO who WP cord-010092-uftc8inx 8473 2 estimates estimate VBZ cord-010092-uftc8inx 8473 3 that that IN cord-010092-uftc8inx 8473 4 there there EX cord-010092-uftc8inx 8473 5 are be VBP cord-010092-uftc8inx 8473 6 20 20 CD cord-010092-uftc8inx 8473 7 million million CD cord-010092-uftc8inx 8473 8 HEV HEV NNP cord-010092-uftc8inx 8473 9 infections infection NNS cord-010092-uftc8inx 8473 10 , , , cord-010092-uftc8inx 8473 11 3 3 CD cord-010092-uftc8inx 8473 12 million million CD cord-010092-uftc8inx 8473 13 acute acute JJ cord-010092-uftc8inx 8473 14 HEV HEV NNP cord-010092-uftc8inx 8473 15 cases case NNS cord-010092-uftc8inx 8473 16 and and CC cord-010092-uftc8inx 8473 17 56 56 CD cord-010092-uftc8inx 8473 18 thousands thousand NNS cord-010092-uftc8inx 8473 19 HEVrelated hevrelate VBN cord-010092-uftc8inx 8473 20 deaths death NNS cord-010092-uftc8inx 8473 21 worldwide worldwide RB cord-010092-uftc8inx 8473 22 each each DT cord-010092-uftc8inx 8473 23 year year NN cord-010092-uftc8inx 8473 24 . . . cord-010092-uftc8inx 8474 1 In in IN cord-010092-uftc8inx 8474 2 recent recent JJ cord-010092-uftc8inx 8474 3 years year NNS cord-010092-uftc8inx 8474 4 , , , cord-010092-uftc8inx 8474 5 the the DT cord-010092-uftc8inx 8474 6 prevalence prevalence NN cord-010092-uftc8inx 8474 7 of of IN cord-010092-uftc8inx 8474 8 HEV HEV NNP cord-010092-uftc8inx 8474 9 in in IN cord-010092-uftc8inx 8474 10 European european JJ cord-010092-uftc8inx 8474 11 and and CC cord-010092-uftc8inx 8474 12 American american JJ cord-010092-uftc8inx 8474 13 countries country NNS cord-010092-uftc8inx 8474 14 has have VBZ cord-010092-uftc8inx 8474 15 increased increase VBN cord-010092-uftc8inx 8474 16 significantly significantly RB cord-010092-uftc8inx 8474 17 . . . cord-010092-uftc8inx 8475 1 The the DT cord-010092-uftc8inx 8475 2 survey survey NN cord-010092-uftc8inx 8475 3 results result VBZ cord-010092-uftc8inx 8475 4 show show VBP cord-010092-uftc8inx 8475 5 that that IN cord-010092-uftc8inx 8475 6 the the DT cord-010092-uftc8inx 8475 7 positive positive JJ cord-010092-uftc8inx 8475 8 rate rate NN cord-010092-uftc8inx 8475 9 of of IN cord-010092-uftc8inx 8475 10 HEV HEV NNP cord-010092-uftc8inx 8475 11 IgG igg NN cord-010092-uftc8inx 8475 12 in in IN cord-010092-uftc8inx 8475 13 blood blood NN cord-010092-uftc8inx 8475 14 donors donor NNS cord-010092-uftc8inx 8475 15 is be VBZ cord-010092-uftc8inx 8475 16 respectively respectively RB cord-010092-uftc8inx 8475 17 4.0 4.0 CD cord-010092-uftc8inx 8475 18 % % NN cord-010092-uftc8inx 8475 19 in in IN cord-010092-uftc8inx 8475 20 New New NNP cord-010092-uftc8inx 8475 21 Zealand Zealand NNP cord-010092-uftc8inx 8475 22 , , , cord-010092-uftc8inx 8475 23 13.5 13.5 CD cord-010092-uftc8inx 8475 24 % % NN cord-010092-uftc8inx 8475 25 in in IN cord-010092-uftc8inx 8475 26 Britain Britain NNP cord-010092-uftc8inx 8475 27 , , , cord-010092-uftc8inx 8475 28 20.6 20.6 CD cord-010092-uftc8inx 8475 29 % % NN cord-010092-uftc8inx 8475 30 in in IN cord-010092-uftc8inx 8475 31 Denmark Denmark NNP cord-010092-uftc8inx 8475 32 , , , cord-010092-uftc8inx 8475 33 16 16 CD cord-010092-uftc8inx 8475 34 % % NN cord-010092-uftc8inx 8475 35 in in IN cord-010092-uftc8inx 8475 36 the the DT cord-010092-uftc8inx 8475 37 United United NNP cord-010092-uftc8inx 8475 38 States States NNP cord-010092-uftc8inx 8475 39 and and CC cord-010092-uftc8inx 8475 40 27.0 27.0 CD cord-010092-uftc8inx 8475 41 % % NN cord-010092-uftc8inx 8475 42 in in IN cord-010092-uftc8inx 8475 43 the the DT cord-010092-uftc8inx 8475 44 Netherlands Netherlands NNP cord-010092-uftc8inx 8475 45 . . . cord-010092-uftc8inx 8476 1 HEV HEV NNP cord-010092-uftc8inx 8476 2 has have VBZ cord-010092-uftc8inx 8476 3 become become VBN cord-010092-uftc8inx 8476 4 a a DT cord-010092-uftc8inx 8476 5 global global JJ cord-010092-uftc8inx 8476 6 public public JJ cord-010092-uftc8inx 8476 7 health health NN cord-010092-uftc8inx 8476 8 concern concern NN cord-010092-uftc8inx 8476 9 . . . cord-010092-uftc8inx 8477 1 In in IN cord-010092-uftc8inx 8477 2 addition addition NN cord-010092-uftc8inx 8477 3 to to IN cord-010092-uftc8inx 8477 4 the the DT cord-010092-uftc8inx 8477 5 food food NN cord-010092-uftc8inx 8477 6 route route NN cord-010092-uftc8inx 8477 7 of of IN cord-010092-uftc8inx 8477 8 infection infection NN cord-010092-uftc8inx 8477 9 , , , cord-010092-uftc8inx 8477 10 several several JJ cord-010092-uftc8inx 8477 11 cases case NNS cord-010092-uftc8inx 8477 12 have have VBP cord-010092-uftc8inx 8477 13 been be VBN cord-010092-uftc8inx 8477 14 reported report VBN cord-010092-uftc8inx 8477 15 that that IN cord-010092-uftc8inx 8477 16 HEV HEV NNP cord-010092-uftc8inx 8477 17 can can MD cord-010092-uftc8inx 8477 18 be be VB cord-010092-uftc8inx 8477 19 transmitted transmit VBN cord-010092-uftc8inx 8477 20 via via IN cord-010092-uftc8inx 8477 21 blood blood NN cord-010092-uftc8inx 8477 22 products product NNS cord-010092-uftc8inx 8477 23 . . . cord-010092-uftc8inx 8478 1 Aims aim VBZ cord-010092-uftc8inx 8478 2 : : : cord-010092-uftc8inx 8479 1 To to TO cord-010092-uftc8inx 8479 2 investigate investigate VB cord-010092-uftc8inx 8479 3 the the DT cord-010092-uftc8inx 8479 4 prevalence prevalence NN cord-010092-uftc8inx 8479 5 of of IN cord-010092-uftc8inx 8479 6 hepatitis hepatitis NN cord-010092-uftc8inx 8479 7 E e NN cord-010092-uftc8inx 8479 8 virus virus NN cord-010092-uftc8inx 8479 9 ( ( -LRB- cord-010092-uftc8inx 8479 10 HEV hev NN cord-010092-uftc8inx 8479 11 ) ) -RRB- cord-010092-uftc8inx 8479 12 infection infection NN cord-010092-uftc8inx 8479 13 among among IN cord-010092-uftc8inx 8479 14 voluntary voluntary JJ cord-010092-uftc8inx 8479 15 blood blood NN cord-010092-uftc8inx 8479 16 donors donor NNS cord-010092-uftc8inx 8479 17 and and CC cord-010092-uftc8inx 8479 18 potential potential JJ cord-010092-uftc8inx 8479 19 impact impact NN cord-010092-uftc8inx 8479 20 on on IN cord-010092-uftc8inx 8479 21 blood blood NN cord-010092-uftc8inx 8479 22 safety safety NN cord-010092-uftc8inx 8479 23 in in IN cord-010092-uftc8inx 8479 24 Guangzhou Guangzhou NNP cord-010092-uftc8inx 8479 25 China China NNP cord-010092-uftc8inx 8479 26 . . . cord-010092-uftc8inx 8480 1 Methods method NNS cord-010092-uftc8inx 8480 2 : : : cord-010092-uftc8inx 8480 3 Blood blood NN cord-010092-uftc8inx 8480 4 samples sample NNS cord-010092-uftc8inx 8480 5 from from IN cord-010092-uftc8inx 8480 6 5552 5552 CD cord-010092-uftc8inx 8480 7 blood blood NN cord-010092-uftc8inx 8480 8 donors donor NNS cord-010092-uftc8inx 8480 9 were be VBD cord-010092-uftc8inx 8480 10 collected collect VBN cord-010092-uftc8inx 8480 11 from from IN cord-010092-uftc8inx 8480 12 April April NNP cord-010092-uftc8inx 8480 13 2017 2017 CD cord-010092-uftc8inx 8480 14 to to IN cord-010092-uftc8inx 8480 15 April April NNP cord-010092-uftc8inx 8480 16 2008 2008 CD cord-010092-uftc8inx 8480 17 at at IN cord-010092-uftc8inx 8480 18 the the DT cord-010092-uftc8inx 8480 19 Guangzhou Guangzhou NNP cord-010092-uftc8inx 8480 20 Blood Blood NNP cord-010092-uftc8inx 8480 21 Center Center NNP cord-010092-uftc8inx 8480 22 and and CC cord-010092-uftc8inx 8480 23 were be VBD cord-010092-uftc8inx 8480 24 tested test VBN cord-010092-uftc8inx 8480 25 for for IN cord-010092-uftc8inx 8480 26 anti anti JJ cord-010092-uftc8inx 8480 27 - - JJ cord-010092-uftc8inx 8480 28 HEV hev JJ cord-010092-uftc8inx 8480 29 IgG igg NN cord-010092-uftc8inx 8480 30 antibody antibody NN cord-010092-uftc8inx 8480 31 ( ( -LRB- cord-010092-uftc8inx 8480 32 HEV HEV NNP cord-010092-uftc8inx 8480 33 IgG IgG NNP cord-010092-uftc8inx 8480 34 ) ) -RRB- cord-010092-uftc8inx 8480 35 , , , cord-010092-uftc8inx 8480 36 anti anti JJ cord-010092-uftc8inx 8480 37 - - JJ cord-010092-uftc8inx 8480 38 HEV hev JJ cord-010092-uftc8inx 8480 39 IgM IgM NNP cord-010092-uftc8inx 8480 40 antibody antibody NN cord-010092-uftc8inx 8480 41 ( ( -LRB- cord-010092-uftc8inx 8480 42 HEV HEV NNP cord-010092-uftc8inx 8480 43 IgM IgM NNP cord-010092-uftc8inx 8480 44 ) ) -RRB- cord-010092-uftc8inx 8480 45 and and CC cord-010092-uftc8inx 8480 46 HEV HEV NNP cord-010092-uftc8inx 8480 47 antigen antigen NN cord-010092-uftc8inx 8480 48 ( ( -LRB- cord-010092-uftc8inx 8480 49 HEV HEV NNP cord-010092-uftc8inx 8480 50 Ag)by ag)by CD cord-010092-uftc8inx 8480 51 enzyme enzyme NN cord-010092-uftc8inx 8480 52 linked link VBN cord-010092-uftc8inx 8480 53 immunosorbent immunosorbent JJ cord-010092-uftc8inx 8480 54 assay assay NN cord-010092-uftc8inx 8480 55 ( ( -LRB- cord-010092-uftc8inx 8480 56 ELISA ELISA NNP cord-010092-uftc8inx 8480 57 ) ) -RRB- cord-010092-uftc8inx 8480 58 . . . cord-010092-uftc8inx 8481 1 HEV HEV NNP cord-010092-uftc8inx 8481 2 RNA RNA NNP cord-010092-uftc8inx 8481 3 detection detection NN cord-010092-uftc8inx 8481 4 was be VBD cord-010092-uftc8inx 8481 5 performed perform VBN cord-010092-uftc8inx 8481 6 on on IN cord-010092-uftc8inx 8481 7 HEV HEV NNP cord-010092-uftc8inx 8481 8 antigen antigen NN cord-010092-uftc8inx 8481 9 positive positive JJ cord-010092-uftc8inx 8481 10 samples sample NNS cord-010092-uftc8inx 8481 11 by by IN cord-010092-uftc8inx 8481 12 RT RT NNP cord-010092-uftc8inx 8481 13 - - HYPH cord-010092-uftc8inx 8481 14 PCR PCR NNP cord-010092-uftc8inx 8481 15 . . . cord-010092-uftc8inx 8482 1 The the DT cord-010092-uftc8inx 8482 2 association association NN cord-010092-uftc8inx 8482 3 of of IN cord-010092-uftc8inx 8482 4 age age NN cord-010092-uftc8inx 8482 5 , , , cord-010092-uftc8inx 8482 6 gender gender NN cord-010092-uftc8inx 8482 7 , , , cord-010092-uftc8inx 8482 8 ethnicity ethnicity NN cord-010092-uftc8inx 8482 9 , , , cord-010092-uftc8inx 8482 10 occupation occupation NN cord-010092-uftc8inx 8482 11 and and CC cord-010092-uftc8inx 8482 12 ALT alt NN cord-010092-uftc8inx 8482 13 with with IN cord-010092-uftc8inx 8482 14 HEV HEV NNP cord-010092-uftc8inx 8482 15 IgG IgG NNP cord-010092-uftc8inx 8482 16 and and CC cord-010092-uftc8inx 8482 17 IgM IgM NNP cord-010092-uftc8inx 8482 18 were be VBD cord-010092-uftc8inx 8482 19 analyzed analyze VBN cord-010092-uftc8inx 8482 20 by by IN cord-010092-uftc8inx 8482 21 Chi Chi NNP cord-010092-uftc8inx 8482 22 - - HYPH cord-010092-uftc8inx 8482 23 square square JJ cord-010092-uftc8inx 8482 24 test test NN cord-010092-uftc8inx 8482 25 . . . cord-010092-uftc8inx 8483 1 Multivariate multivariate JJ cord-010092-uftc8inx 8483 2 logistic logistic JJ cord-010092-uftc8inx 8483 3 regression regression NN cord-010092-uftc8inx 8483 4 analysis analysis NN cord-010092-uftc8inx 8483 5 was be VBD cord-010092-uftc8inx 8483 6 applied apply VBN cord-010092-uftc8inx 8483 7 to to TO cord-010092-uftc8inx 8483 8 identify identify VB cord-010092-uftc8inx 8483 9 the the DT cord-010092-uftc8inx 8483 10 independent independent JJ cord-010092-uftc8inx 8483 11 risk risk NN cord-010092-uftc8inx 8483 12 factors factor NNS cord-010092-uftc8inx 8483 13 of of IN cord-010092-uftc8inx 8483 14 HEV HEV NNP cord-010092-uftc8inx 8483 15 infection infection NN cord-010092-uftc8inx 8483 16 . . . cord-010092-uftc8inx 8484 1 Results result NNS cord-010092-uftc8inx 8484 2 : : : cord-010092-uftc8inx 8485 1 The the DT cord-010092-uftc8inx 8485 2 positive positive JJ cord-010092-uftc8inx 8485 3 rates rate NNS cord-010092-uftc8inx 8485 4 of of IN cord-010092-uftc8inx 8485 5 HEV HEV NNP cord-010092-uftc8inx 8485 6 IgG IgG NNP cord-010092-uftc8inx 8485 7 , , , cord-010092-uftc8inx 8485 8 IgM IgM NNP cord-010092-uftc8inx 8485 9 and and CC cord-010092-uftc8inx 8485 10 HEV HEV NNP cord-010092-uftc8inx 8485 11 Ag Ag NNP cord-010092-uftc8inx 8485 12 were be VBD cord-010092-uftc8inx 8485 13 20.05 20.05 CD cord-010092-uftc8inx 8485 14 % % NN cord-010092-uftc8inx 8485 15 ( ( -LRB- cord-010092-uftc8inx 8485 16 1113/5552 1113/5552 CD cord-010092-uftc8inx 8485 17 ) ) -RRB- cord-010092-uftc8inx 8485 18 , , , cord-010092-uftc8inx 8485 19 0.76 0.76 CD cord-010092-uftc8inx 8485 20 % % NN cord-010092-uftc8inx 8485 21 ( ( -LRB- cord-010092-uftc8inx 8485 22 42/5552 42/5552 CD cord-010092-uftc8inx 8485 23 ) ) -RRB- cord-010092-uftc8inx 8485 24 and and CC cord-010092-uftc8inx 8485 25 0.04 0.04 CD cord-010092-uftc8inx 8485 26 % % NN cord-010092-uftc8inx 8485 27 ( ( -LRB- cord-010092-uftc8inx 8485 28 2/5552 2/5552 NNP cord-010092-uftc8inx 8485 29 ) ) -RRB- cord-010092-uftc8inx 8485 30 , , , cord-010092-uftc8inx 8485 31 respectively respectively RB cord-010092-uftc8inx 8485 32 . . . cord-010092-uftc8inx 8486 1 No no DT cord-010092-uftc8inx 8486 2 positive positive JJ cord-010092-uftc8inx 8486 3 HEV HEV NNP cord-010092-uftc8inx 8486 4 RNA RNA NNP cord-010092-uftc8inx 8486 5 was be VBD cord-010092-uftc8inx 8486 6 detected detect VBN cord-010092-uftc8inx 8486 7 . . . cord-010092-uftc8inx 8487 1 Age age NN cord-010092-uftc8inx 8487 2 and and CC cord-010092-uftc8inx 8487 3 ethnicity ethnicity NN cord-010092-uftc8inx 8487 4 were be VBD cord-010092-uftc8inx 8487 5 independent independent JJ cord-010092-uftc8inx 8487 6 risk risk NN cord-010092-uftc8inx 8487 7 factors factor NNS cord-010092-uftc8inx 8487 8 for for IN cord-010092-uftc8inx 8487 9 HEV HEV NNP cord-010092-uftc8inx 8487 10 IgG igg NN cord-010092-uftc8inx 8487 11 and and CC cord-010092-uftc8inx 8487 12 HEV hev VB cord-010092-uftc8inx 8487 13 IgM. IgM. NNP cord-010092-uftc8inx 8488 1 The the DT cord-010092-uftc8inx 8488 2 rate rate NN cord-010092-uftc8inx 8488 3 of of IN cord-010092-uftc8inx 8488 4 HEV HEV NNP cord-010092-uftc8inx 8488 5 antibody antibody NN cord-010092-uftc8inx 8488 6 increased increase VBD cord-010092-uftc8inx 8488 7 significantly significantly RB cord-010092-uftc8inx 8488 8 with with IN cord-010092-uftc8inx 8488 9 age age NN cord-010092-uftc8inx 8488 10 ( ( -LRB- cord-010092-uftc8inx 8488 11 IgG IgG NNP cord-010092-uftc8inx 8488 12 OR or CC cord-010092-uftc8inx 8488 13 = = SYM cord-010092-uftc8inx 8488 14 1.089 1.089 CD cord-010092-uftc8inx 8488 15 , , , cord-010092-uftc8inx 8488 16 P p NN cord-010092-uftc8inx 8488 17 < < XX cord-010092-uftc8inx 8488 18 0.001 0.001 XX cord-010092-uftc8inx 8488 19 ; ; : cord-010092-uftc8inx 8488 20 IgM IgM NNP cord-010092-uftc8inx 8488 21 OR OR NNP cord-010092-uftc8inx 8488 22 = = SYM cord-010092-uftc8inx 8488 23 1.055 1.055 CD cord-010092-uftc8inx 8488 24 , , , cord-010092-uftc8inx 8488 25 P p NN cord-010092-uftc8inx 8488 26 < < XX cord-010092-uftc8inx 8488 27 0.001 0.001 CD cord-010092-uftc8inx 8488 28 ) ) -RRB- cord-010092-uftc8inx 8488 29 . . . cord-010092-uftc8inx 8489 1 Donors donor NNS cord-010092-uftc8inx 8489 2 who who WP cord-010092-uftc8inx 8489 3 were be VBD cord-010092-uftc8inx 8489 4 Zhuang Zhuang NNP cord-010092-uftc8inx 8489 5 minority minority NN cord-010092-uftc8inx 8489 6 ( ( -LRB- cord-010092-uftc8inx 8489 7 32.69 32.69 CD cord-010092-uftc8inx 8489 8 % % NN cord-010092-uftc8inx 8489 9 , , , cord-010092-uftc8inx 8489 10 7.69 7.69 CD cord-010092-uftc8inx 8489 11 % % NN cord-010092-uftc8inx 8489 12 ) ) -RRB- cord-010092-uftc8inx 8489 13 showed show VBD cord-010092-uftc8inx 8489 14 higher high JJR cord-010092-uftc8inx 8489 15 anti anti JJ cord-010092-uftc8inx 8489 16 - - JJ cord-010092-uftc8inx 8489 17 HEV hev JJ cord-010092-uftc8inx 8489 18 than than IN cord-010092-uftc8inx 8489 19 those those DT cord-010092-uftc8inx 8489 20 who who WP cord-010092-uftc8inx 8489 21 were be VBD cord-010092-uftc8inx 8489 22 Han Han NNP cord-010092-uftc8inx 8489 23 ethnicity ethnicity NN cord-010092-uftc8inx 8489 24 ( ( -LRB- cord-010092-uftc8inx 8489 25 19.89 19.89 CD cord-010092-uftc8inx 8489 26 % % NN cord-010092-uftc8inx 8489 27 , , , cord-010092-uftc8inx 8489 28 0.70 0.70 CD cord-010092-uftc8inx 8489 29 % % NN cord-010092-uftc8inx 8489 30 ) ) -RRB- cord-010092-uftc8inx 8489 31 , , , cord-010092-uftc8inx 8489 32 and and CC cord-010092-uftc8inx 8489 33 the the DT cord-010092-uftc8inx 8489 34 difference difference NN cord-010092-uftc8inx 8489 35 was be VBD cord-010092-uftc8inx 8489 36 statistically statistically RB cord-010092-uftc8inx 8489 37 significant significant JJ cord-010092-uftc8inx 8489 38 ( ( -LRB- cord-010092-uftc8inx 8489 39 IgG IgG NNP cord-010092-uftc8inx 8489 40 OR or CC cord-010092-uftc8inx 8489 41 = = SYM cord-010092-uftc8inx 8489 42 2.052 2.052 CD cord-010092-uftc8inx 8489 43 , , , cord-010092-uftc8inx 8489 44 P p NN cord-010092-uftc8inx 8489 45 = = SYM cord-010092-uftc8inx 8489 46 0.023 0.023 XX cord-010092-uftc8inx 8489 47 ; ; : cord-010092-uftc8inx 8489 48 IgM IgM NNP cord-010092-uftc8inx 8489 49 OR OR NNP cord-010092-uftc8inx 8489 50 = = SYM cord-010092-uftc8inx 8489 51 12.029 12.029 CD cord-010092-uftc8inx 8489 52 , , , cord-010092-uftc8inx 8489 53 P p NN cord-010092-uftc8inx 8489 54 < < XX cord-010092-uftc8inx 8489 55 0.001 0.001 CD cord-010092-uftc8inx 8489 56 ) ) -RRB- cord-010092-uftc8inx 8489 57 . . . cord-010092-uftc8inx 8490 1 In in IN cord-010092-uftc8inx 8490 2 addition addition NN cord-010092-uftc8inx 8490 3 , , , cord-010092-uftc8inx 8490 4 we -PRON- PRP cord-010092-uftc8inx 8490 5 found find VBD cord-010092-uftc8inx 8490 6 that that IN cord-010092-uftc8inx 8490 7 occupation occupation NN cord-010092-uftc8inx 8490 8 was be VBD cord-010092-uftc8inx 8490 9 an an DT cord-010092-uftc8inx 8490 10 independent independent JJ cord-010092-uftc8inx 8490 11 risk risk NN cord-010092-uftc8inx 8490 12 factor factor NN cord-010092-uftc8inx 8490 13 for for IN cord-010092-uftc8inx 8490 14 HEV HEV NNP cord-010092-uftc8inx 8490 15 infection infection NN cord-010092-uftc8inx 8490 16 , , , cord-010092-uftc8inx 8490 17 where where WRB cord-010092-uftc8inx 8490 18 students student NNS cord-010092-uftc8inx 8490 19 showed show VBD cord-010092-uftc8inx 8490 20 the the DT cord-010092-uftc8inx 8490 21 lowest low JJS cord-010092-uftc8inx 8490 22 anti anti JJ cord-010092-uftc8inx 8490 23 - - JJ cord-010092-uftc8inx 8490 24 HEV hev JJ cord-010092-uftc8inx 8490 25 rate rate NN cord-010092-uftc8inx 8490 26 . . . cord-010092-uftc8inx 8491 1 Summary Summary NNP cord-010092-uftc8inx 8491 2 / / SYM cord-010092-uftc8inx 8491 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 8491 4 : : : cord-010092-uftc8inx 8492 1 The the DT cord-010092-uftc8inx 8492 2 results result NNS cord-010092-uftc8inx 8492 3 indicate indicate VBP cord-010092-uftc8inx 8492 4 that that IN cord-010092-uftc8inx 8492 5 the the DT cord-010092-uftc8inx 8492 6 positive positive JJ cord-010092-uftc8inx 8492 7 rate rate NN cord-010092-uftc8inx 8492 8 of of IN cord-010092-uftc8inx 8492 9 HEV HEV NNP cord-010092-uftc8inx 8492 10 antibody antibody NN cord-010092-uftc8inx 8492 11 among among IN cord-010092-uftc8inx 8492 12 blood blood NN cord-010092-uftc8inx 8492 13 donors donor NNS cord-010092-uftc8inx 8492 14 in in IN cord-010092-uftc8inx 8492 15 Guangzhou Guangzhou NNP cord-010092-uftc8inx 8492 16 is be VBZ cord-010092-uftc8inx 8492 17 high high JJ cord-010092-uftc8inx 8492 18 , , , cord-010092-uftc8inx 8492 19 and and CC cord-010092-uftc8inx 8492 20 the the DT cord-010092-uftc8inx 8492 21 infection infection NN cord-010092-uftc8inx 8492 22 status status NN cord-010092-uftc8inx 8492 23 differs differ VBZ cord-010092-uftc8inx 8492 24 in in IN cord-010092-uftc8inx 8492 25 different different JJ cord-010092-uftc8inx 8492 26 populations population NNS cord-010092-uftc8inx 8492 27 . . . cord-010092-uftc8inx 8493 1 Our -PRON- PRP$ cord-010092-uftc8inx 8493 2 study study NN cord-010092-uftc8inx 8493 3 provides provide VBZ cord-010092-uftc8inx 8493 4 basic basic JJ cord-010092-uftc8inx 8493 5 data datum NNS cord-010092-uftc8inx 8493 6 for for IN cord-010092-uftc8inx 8493 7 the the DT cord-010092-uftc8inx 8493 8 estimation estimation NN cord-010092-uftc8inx 8493 9 of of IN cord-010092-uftc8inx 8493 10 risk risk NN cord-010092-uftc8inx 8493 11 of of IN cord-010092-uftc8inx 8493 12 transfusion transfusion NN cord-010092-uftc8inx 8493 13 - - HYPH cord-010092-uftc8inx 8493 14 transmitted transmit VBN cord-010092-uftc8inx 8493 15 HEV hev NN cord-010092-uftc8inx 8493 16 . . . cord-010092-uftc8inx 8494 1 Background background NN cord-010092-uftc8inx 8494 2 : : : cord-010092-uftc8inx 8495 1 Human human JJ cord-010092-uftc8inx 8495 2 cytomegalovirus cytomegalovirus NN cord-010092-uftc8inx 8495 3 ( ( -LRB- cord-010092-uftc8inx 8495 4 HCMV HCMV NNP cord-010092-uftc8inx 8495 5 ) ) -RRB- cord-010092-uftc8inx 8495 6 belongs belong VBZ cord-010092-uftc8inx 8495 7 to to IN cord-010092-uftc8inx 8495 8 the the DT cord-010092-uftc8inx 8495 9 viral viral JJ cord-010092-uftc8inx 8495 10 family family NN cord-010092-uftc8inx 8495 11 of of IN cord-010092-uftc8inx 8495 12 Herpesviridae Herpesviridae NNP cord-010092-uftc8inx 8495 13 . . . cord-010092-uftc8inx 8496 1 It -PRON- PRP cord-010092-uftc8inx 8496 2 is be VBZ cord-010092-uftc8inx 8496 3 an an DT cord-010092-uftc8inx 8496 4 enveloped envelop VBN cord-010092-uftc8inx 8496 5 double double RB cord-010092-uftc8inx 8496 6 - - HYPH cord-010092-uftc8inx 8496 7 stranded strand VBN cord-010092-uftc8inx 8496 8 DNA dna NN cord-010092-uftc8inx 8496 9 virus virus NN cord-010092-uftc8inx 8496 10 , , , cord-010092-uftc8inx 8496 11 widely widely RB cord-010092-uftc8inx 8496 12 distributed distribute VBN cord-010092-uftc8inx 8496 13 in in IN cord-010092-uftc8inx 8496 14 the the DT cord-010092-uftc8inx 8496 15 human human JJ cord-010092-uftc8inx 8496 16 population population NN cord-010092-uftc8inx 8496 17 ( ( -LRB- cord-010092-uftc8inx 8496 18 60 60 CD cord-010092-uftc8inx 8496 19 - - SYM cord-010092-uftc8inx 8496 20 100 100 CD cord-010092-uftc8inx 8496 21 % % NN cord-010092-uftc8inx 8496 22 seropositive seropositive JJ cord-010092-uftc8inx 8496 23 subjects subject NNS cord-010092-uftc8inx 8496 24 worldwide worldwide RB cord-010092-uftc8inx 8496 25 ) ) -RRB- cord-010092-uftc8inx 8496 26 and and CC cord-010092-uftc8inx 8496 27 cause cause NN cord-010092-uftc8inx 8496 28 of of IN cord-010092-uftc8inx 8496 29 severe severe JJ cord-010092-uftc8inx 8496 30 disease disease NN cord-010092-uftc8inx 8496 31 in in IN cord-010092-uftc8inx 8496 32 immunocompromised immunocompromised JJ cord-010092-uftc8inx 8496 33 patients patient NNS cord-010092-uftc8inx 8496 34 and and CC cord-010092-uftc8inx 8496 35 upon upon IN cord-010092-uftc8inx 8496 36 infection infection NN cord-010092-uftc8inx 8496 37 of of IN cord-010092-uftc8inx 8496 38 the the DT cord-010092-uftc8inx 8496 39 foetus foetus NN cord-010092-uftc8inx 8496 40 . . . cord-010092-uftc8inx 8497 1 In in IN cord-010092-uftc8inx 8497 2 normally normally RB cord-010092-uftc8inx 8497 3 healthy healthy JJ cord-010092-uftc8inx 8497 4 subjects subject NNS cord-010092-uftc8inx 8497 5 , , , cord-010092-uftc8inx 8497 6 HCMV HCMV NNP cord-010092-uftc8inx 8497 7 persists persist VBZ cord-010092-uftc8inx 8497 8 lifelong lifelong JJ cord-010092-uftc8inx 8497 9 without without IN cord-010092-uftc8inx 8497 10 clinical clinical JJ cord-010092-uftc8inx 8497 11 manifestation manifestation NN cord-010092-uftc8inx 8497 12 undergoing undergo VBG cord-010092-uftc8inx 8497 13 alternating alternate VBG cord-010092-uftc8inx 8497 14 phases phase NNS cord-010092-uftc8inx 8497 15 of of IN cord-010092-uftc8inx 8497 16 active active JJ cord-010092-uftc8inx 8497 17 viral viral JJ cord-010092-uftc8inx 8497 18 replication replication NN cord-010092-uftc8inx 8497 19 and and CC cord-010092-uftc8inx 8497 20 latency latency NN cord-010092-uftc8inx 8497 21 . . . cord-010092-uftc8inx 8498 1 Since since IN cord-010092-uftc8inx 8498 2 HCMV HCMV NNP cord-010092-uftc8inx 8498 3 can can MD cord-010092-uftc8inx 8498 4 be be VB cord-010092-uftc8inx 8498 5 readily readily RB cord-010092-uftc8inx 8498 6 detected detect VBN cord-010092-uftc8inx 8498 7 in in IN cord-010092-uftc8inx 8498 8 blood blood NN cord-010092-uftc8inx 8498 9 , , , cord-010092-uftc8inx 8498 10 as as IN cord-010092-uftc8inx 8498 11 free free JJ cord-010092-uftc8inx 8498 12 virus virus NN cord-010092-uftc8inx 8498 13 as as RB cord-010092-uftc8inx 8498 14 well well RB cord-010092-uftc8inx 8498 15 as as IN cord-010092-uftc8inx 8498 16 associated associate VBN cord-010092-uftc8inx 8498 17 to to IN cord-010092-uftc8inx 8498 18 neutrophils neutrophil NNS cord-010092-uftc8inx 8498 19 and and CC cord-010092-uftc8inx 8498 20 monocytes monocyte NNS cord-010092-uftc8inx 8498 21 , , , cord-010092-uftc8inx 8498 22 HCMV HCMV NNP cord-010092-uftc8inx 8498 23 transmission transmission NN cord-010092-uftc8inx 8498 24 is be VBZ cord-010092-uftc8inx 8498 25 a a DT cord-010092-uftc8inx 8498 26 complication complication NN cord-010092-uftc8inx 8498 27 of of IN cord-010092-uftc8inx 8498 28 blood blood NN cord-010092-uftc8inx 8498 29 transfusion transfusion NN cord-010092-uftc8inx 8498 30 . . . cord-010092-uftc8inx 8499 1 Even even RB cord-010092-uftc8inx 8499 2 though though IN cord-010092-uftc8inx 8499 3 leukoreduction leukoreduction NN cord-010092-uftc8inx 8499 4 of of IN cord-010092-uftc8inx 8499 5 blood blood NN cord-010092-uftc8inx 8499 6 products product NNS cord-010092-uftc8inx 8499 7 has have VBZ cord-010092-uftc8inx 8499 8 been be VBN cord-010092-uftc8inx 8499 9 shown show VBN cord-010092-uftc8inx 8499 10 to to TO cord-010092-uftc8inx 8499 11 significantly significantly RB cord-010092-uftc8inx 8499 12 reduce reduce VB cord-010092-uftc8inx 8499 13 the the DT cord-010092-uftc8inx 8499 14 risk risk NN cord-010092-uftc8inx 8499 15 of of IN cord-010092-uftc8inx 8499 16 HCMV HCMV NNP cord-010092-uftc8inx 8499 17 transmission transmission NN cord-010092-uftc8inx 8499 18 , , , cord-010092-uftc8inx 8499 19 higher high JJR cord-010092-uftc8inx 8499 20 inactivation inactivation NN cord-010092-uftc8inx 8499 21 standards standard NNS cord-010092-uftc8inx 8499 22 may may MD cord-010092-uftc8inx 8499 23 be be VB cord-010092-uftc8inx 8499 24 required require VBN cord-010092-uftc8inx 8499 25 for for IN cord-010092-uftc8inx 8499 26 high high JJ cord-010092-uftc8inx 8499 27 - - HYPH cord-010092-uftc8inx 8499 28 risk risk NN cord-010092-uftc8inx 8499 29 , , , cord-010092-uftc8inx 8499 30 immunocompromised immunocompromised JJ cord-010092-uftc8inx 8499 31 groups group NNS cord-010092-uftc8inx 8499 32 of of IN cord-010092-uftc8inx 8499 33 patients patient NNS cord-010092-uftc8inx 8499 34 . . . cord-010092-uftc8inx 8500 1 Aims aim VBZ cord-010092-uftc8inx 8500 2 : : : cord-010092-uftc8inx 8501 1 In in IN cord-010092-uftc8inx 8501 2 this this DT cord-010092-uftc8inx 8501 3 study study NN cord-010092-uftc8inx 8501 4 , , , cord-010092-uftc8inx 8501 5 murine murine JJ cord-010092-uftc8inx 8501 6 macrophages macrophage NNS cord-010092-uftc8inx 8501 7 infected infect VBN cord-010092-uftc8inx 8501 8 with with IN cord-010092-uftc8inx 8501 9 murine murine JJ cord-010092-uftc8inx 8501 10 cytomegalovirus cytomegalovirus NN cord-010092-uftc8inx 8501 11 ( ( -LRB- cord-010092-uftc8inx 8501 12 MCMV MCMV NNP cord-010092-uftc8inx 8501 13 ) ) -RRB- cord-010092-uftc8inx 8501 14 were be VBD cord-010092-uftc8inx 8501 15 used use VBN cord-010092-uftc8inx 8501 16 as as IN cord-010092-uftc8inx 8501 17 a a DT cord-010092-uftc8inx 8501 18 model model NN cord-010092-uftc8inx 8501 19 to to TO cord-010092-uftc8inx 8501 20 study study VB cord-010092-uftc8inx 8501 21 the the DT cord-010092-uftc8inx 8501 22 inactivation inactivation NN cord-010092-uftc8inx 8501 23 cell cell NN cord-010092-uftc8inx 8501 24 - - HYPH cord-010092-uftc8inx 8501 25 associated associate VBN cord-010092-uftc8inx 8501 26 CMV CMV NNP cord-010092-uftc8inx 8501 27 in in IN cord-010092-uftc8inx 8501 28 human human JJ cord-010092-uftc8inx 8501 29 plasma plasma NN cord-010092-uftc8inx 8501 30 using use VBG cord-010092-uftc8inx 8501 31 the the DT cord-010092-uftc8inx 8501 32 THERAFLEX THERAFLEX NNP cord-010092-uftc8inx 8501 33 MB MB NNP cord-010092-uftc8inx 8501 34 - - HYPH cord-010092-uftc8inx 8501 35 Plasma plasma NN cord-010092-uftc8inx 8501 36 system system NN cord-010092-uftc8inx 8501 37 ( ( -LRB- cord-010092-uftc8inx 8501 38 Macopharma Macopharma NNP cord-010092-uftc8inx 8501 39 ) ) -RRB- cord-010092-uftc8inx 8501 40 . . . cord-010092-uftc8inx 8502 1 Methods method NNS cord-010092-uftc8inx 8502 2 : : : cord-010092-uftc8inx 8502 3 MCMV MCMV NNP cord-010092-uftc8inx 8502 4 expressing express VBG cord-010092-uftc8inx 8502 5 the the DT cord-010092-uftc8inx 8502 6 green green JJ cord-010092-uftc8inx 8502 7 fluorescent fluorescent NN cord-010092-uftc8inx 8502 8 protein protein NN cord-010092-uftc8inx 8502 9 was be VBD cord-010092-uftc8inx 8502 10 used use VBN cord-010092-uftc8inx 8502 11 to to TO cord-010092-uftc8inx 8502 12 infect infect VB cord-010092-uftc8inx 8502 13 murine murine JJ cord-010092-uftc8inx 8502 14 macrophages macrophage NNS cord-010092-uftc8inx 8502 15 . . . cord-010092-uftc8inx 8503 1 Infected infected JJ cord-010092-uftc8inx 8503 2 macrophages macrophage NNS cord-010092-uftc8inx 8503 3 were be VBD cord-010092-uftc8inx 8503 4 harvested harvest VBN cord-010092-uftc8inx 8503 5 20 20 CD cord-010092-uftc8inx 8503 6 h h NN cord-010092-uftc8inx 8503 7 after after IN cord-010092-uftc8inx 8503 8 infection infection NN cord-010092-uftc8inx 8503 9 , , , cord-010092-uftc8inx 8503 10 washed wash VBN cord-010092-uftc8inx 8503 11 and and CC cord-010092-uftc8inx 8503 12 used use VBN cord-010092-uftc8inx 8503 13 for for IN cord-010092-uftc8inx 8503 14 spiking spiking NN cord-010092-uftc8inx 8503 15 of of IN cord-010092-uftc8inx 8503 16 plasma plasma NN cord-010092-uftc8inx 8503 17 . . . cord-010092-uftc8inx 8504 1 Plasma plasma NN cord-010092-uftc8inx 8504 2 units unit NNS cord-010092-uftc8inx 8504 3 ( ( -LRB- cord-010092-uftc8inx 8504 4 n n NN cord-010092-uftc8inx 8504 5 = = SYM cord-010092-uftc8inx 8504 6 2 2 CD cord-010092-uftc8inx 8504 7 , , , cord-010092-uftc8inx 8504 8 290 290 CD cord-010092-uftc8inx 8504 9 mL mL NNS cord-010092-uftc8inx 8504 10 ) ) -RRB- cord-010092-uftc8inx 8504 11 were be VBD cord-010092-uftc8inx 8504 12 spiked spike VBN cord-010092-uftc8inx 8504 13 with with IN cord-010092-uftc8inx 8504 14 infected infected JJ cord-010092-uftc8inx 8504 15 cell cell NN cord-010092-uftc8inx 8504 16 suspension suspension NN cord-010092-uftc8inx 8504 17 ( ( -LRB- cord-010092-uftc8inx 8504 18 10 10 CD cord-010092-uftc8inx 8504 19 % % NN cord-010092-uftc8inx 8504 20 v v NN cord-010092-uftc8inx 8504 21 / / SYM cord-010092-uftc8inx 8504 22 v v NN cord-010092-uftc8inx 8504 23 ) ) -RRB- cord-010092-uftc8inx 8504 24 and and CC cord-010092-uftc8inx 8504 25 treated treat VBN cord-010092-uftc8inx 8504 26 with with IN cord-010092-uftc8inx 8504 27 the the DT cord-010092-uftc8inx 8504 28 THERAFLEX THERAFLEX NNP cord-010092-uftc8inx 8504 29 MB MB NNP cord-010092-uftc8inx 8504 30 - - HYPH cord-010092-uftc8inx 8504 31 Plasma plasma NN cord-010092-uftc8inx 8504 32 system system NN cord-010092-uftc8inx 8504 33 according accord VBG cord-010092-uftc8inx 8504 34 to to IN cord-010092-uftc8inx 8504 35 the the DT cord-010092-uftc8inx 8504 36 manufacturer manufacturer NN cord-010092-uftc8inx 8504 37 's 's POS cord-010092-uftc8inx 8504 38 protocol protocol NN cord-010092-uftc8inx 8504 39 using use VBG cord-010092-uftc8inx 8504 40 the the DT cord-010092-uftc8inx 8504 41 Macotronic Macotronic NNP cord-010092-uftc8inx 8504 42 - - HYPH cord-010092-uftc8inx 8504 43 B2 B2 NNP cord-010092-uftc8inx 8504 44 illumination illumination NN cord-010092-uftc8inx 8504 45 device device NN cord-010092-uftc8inx 8504 46 ( ( -LRB- cord-010092-uftc8inx 8504 47 Macopharma Macopharma NNP cord-010092-uftc8inx 8504 48 ) ) -RRB- cord-010092-uftc8inx 8504 49 . . . cord-010092-uftc8inx 8505 1 Samples sample NNS cord-010092-uftc8inx 8505 2 were be VBD cord-010092-uftc8inx 8505 3 taken take VBN cord-010092-uftc8inx 8505 4 after after IN cord-010092-uftc8inx 8505 5 spiking spike VBG cord-010092-uftc8inx 8505 6 ( ( -LRB- cord-010092-uftc8inx 8505 7 load load NN cord-010092-uftc8inx 8505 8 and and CC cord-010092-uftc8inx 8505 9 hold hold VB cord-010092-uftc8inx 8505 10 sample sample NN cord-010092-uftc8inx 8505 11 ) ) -RRB- cord-010092-uftc8inx 8505 12 , , , cord-010092-uftc8inx 8505 13 after after IN cord-010092-uftc8inx 8505 14 illumination illumination NN cord-010092-uftc8inx 8505 15 with with IN cord-010092-uftc8inx 8505 16 different different JJ cord-010092-uftc8inx 8505 17 light light JJ cord-010092-uftc8inx 8505 18 doses dose NNS cord-010092-uftc8inx 8505 19 ( ( -LRB- cord-010092-uftc8inx 8505 20 0 0 NFP cord-010092-uftc8inx 8505 21 after after IN cord-010092-uftc8inx 8505 22 addition addition NN cord-010092-uftc8inx 8505 23 of of IN cord-010092-uftc8inx 8505 24 MB mb NN cord-010092-uftc8inx 8505 25 , , , cord-010092-uftc8inx 8505 26 30 30 CD cord-010092-uftc8inx 8505 27 , , , cord-010092-uftc8inx 8505 28 60 60 CD cord-010092-uftc8inx 8505 29 , , , cord-010092-uftc8inx 8505 30 90 90 CD cord-010092-uftc8inx 8505 31 and and CC cord-010092-uftc8inx 8505 32 120 120 CD cord-010092-uftc8inx 8505 33 [ [ -LRB- cord-010092-uftc8inx 8505 34 standard standard NN cord-010092-uftc8inx 8505 35 ] ] -RRB- cord-010092-uftc8inx 8505 36 J J NNP cord-010092-uftc8inx 8505 37 / / SYM cord-010092-uftc8inx 8505 38 cm cm NNP cord-010092-uftc8inx 8505 39 2 2 CD cord-010092-uftc8inx 8505 40 ) ) -RRB- cord-010092-uftc8inx 8505 41 and and CC cord-010092-uftc8inx 8505 42 after after IN cord-010092-uftc8inx 8505 43 Blueflex Blueflex NNP cord-010092-uftc8inx 8505 44 filtration filtration NN cord-010092-uftc8inx 8505 45 . . . cord-010092-uftc8inx 8506 1 MCMV MCMV NNP cord-010092-uftc8inx 8506 2 titers titer NNS cord-010092-uftc8inx 8506 3 were be VBD cord-010092-uftc8inx 8506 4 determined determine VBN cord-010092-uftc8inx 8506 5 by by IN cord-010092-uftc8inx 8506 6 endpoint endpoint NN cord-010092-uftc8inx 8506 7 titration titration NN cord-010092-uftc8inx 8506 8 and and CC cord-010092-uftc8inx 8506 9 large large JJ cord-010092-uftc8inx 8506 10 volume volume NN cord-010092-uftc8inx 8506 11 plating plating NN cord-010092-uftc8inx 8506 12 on on IN cord-010092-uftc8inx 8506 13 murine murine JJ cord-010092-uftc8inx 8506 14 fibroblasts fibroblast NNS cord-010092-uftc8inx 8506 15 . . . cord-010092-uftc8inx 8507 1 Infectious infectious JJ cord-010092-uftc8inx 8507 2 virus virus NN cord-010092-uftc8inx 8507 3 , , , cord-010092-uftc8inx 8507 4 which which WDT cord-010092-uftc8inx 8507 5 expressed express VBD cord-010092-uftc8inx 8507 6 GFP GFP NNP cord-010092-uftc8inx 8507 7 in in IN cord-010092-uftc8inx 8507 8 infected infected JJ cord-010092-uftc8inx 8507 9 cells cell NNS cord-010092-uftc8inx 8507 10 , , , cord-010092-uftc8inx 8507 11 was be VBD cord-010092-uftc8inx 8507 12 detected detect VBN cord-010092-uftc8inx 8507 13 using use VBG cord-010092-uftc8inx 8507 14 a a DT cord-010092-uftc8inx 8507 15 fluorescence fluorescence NN cord-010092-uftc8inx 8507 16 microscope microscope NN cord-010092-uftc8inx 8507 17 . . . cord-010092-uftc8inx 8508 1 Results result NNS cord-010092-uftc8inx 8508 2 : : : cord-010092-uftc8inx 8509 1 The the DT cord-010092-uftc8inx 8509 2 results result NNS cord-010092-uftc8inx 8509 3 of of IN cord-010092-uftc8inx 8509 4 infectivity infectivity NN cord-010092-uftc8inx 8509 5 assay assay NN cord-010092-uftc8inx 8509 6 showed show VBD cord-010092-uftc8inx 8509 7 that that IN cord-010092-uftc8inx 8509 8 the the DT cord-010092-uftc8inx 8509 9 treatment treatment NN cord-010092-uftc8inx 8509 10 of of IN cord-010092-uftc8inx 8509 11 human human JJ cord-010092-uftc8inx 8509 12 plasma plasma NN cord-010092-uftc8inx 8509 13 by by IN cord-010092-uftc8inx 8509 14 the the DT cord-010092-uftc8inx 8509 15 THERAFLEX THERAFLEX NNP cord-010092-uftc8inx 8509 16 MB MB NNP cord-010092-uftc8inx 8509 17 - - HYPH cord-010092-uftc8inx 8509 18 Plasma plasma NN cord-010092-uftc8inx 8509 19 system system NN cord-010092-uftc8inx 8509 20 inactivated inactivate VBD cord-010092-uftc8inx 8509 21 cell cell NN cord-010092-uftc8inx 8509 22 - - HYPH cord-010092-uftc8inx 8509 23 associated associate VBN cord-010092-uftc8inx 8509 24 MCMV MCMV NNP cord-010092-uftc8inx 8509 25 in in IN cord-010092-uftc8inx 8509 26 a a DT cord-010092-uftc8inx 8509 27 dosedependent dosedependent NN cord-010092-uftc8inx 8509 28 manner manner NN cord-010092-uftc8inx 8509 29 . . . cord-010092-uftc8inx 8510 1 After after IN cord-010092-uftc8inx 8510 2 spiking spike VBG cord-010092-uftc8inx 8510 3 with with IN cord-010092-uftc8inx 8510 4 MCMV MCMV NNP cord-010092-uftc8inx 8510 5 infected infect VBN cord-010092-uftc8inx 8510 6 macrophages macrophage NNS cord-010092-uftc8inx 8510 7 a a DT cord-010092-uftc8inx 8510 8 MCMV MCMV NNP cord-010092-uftc8inx 8510 9 titer titer NN cord-010092-uftc8inx 8510 10 of of IN cord-010092-uftc8inx 8510 11 4.2 4.2 CD cord-010092-uftc8inx 8510 12 ( ( -LRB- cord-010092-uftc8inx 8510 13 bag bag NN cord-010092-uftc8inx 8510 14 no no NN cord-010092-uftc8inx 8510 15 . . NN cord-010092-uftc8inx 8510 16 1 1 CD cord-010092-uftc8inx 8510 17 ) ) -RRB- cord-010092-uftc8inx 8510 18 and and CC cord-010092-uftc8inx 8510 19 4.5 4.5 CD cord-010092-uftc8inx 8510 20 ( ( -LRB- cord-010092-uftc8inx 8510 21 bag bag NN cord-010092-uftc8inx 8510 22 no no NN cord-010092-uftc8inx 8510 23 . . NN cord-010092-uftc8inx 8510 24 2 2 LS cord-010092-uftc8inx 8510 25 ) ) -RRB- cord-010092-uftc8inx 8510 26 log log VB cord-010092-uftc8inx 8510 27 10 10 CD cord-010092-uftc8inx 8510 28 TCID TCID NNP cord-010092-uftc8inx 8510 29 50 50 CD cord-010092-uftc8inx 8510 30 /mL /mL : cord-010092-uftc8inx 8510 31 was be VBD cord-010092-uftc8inx 8510 32 achieved achieve VBN cord-010092-uftc8inx 8510 33 in in IN cord-010092-uftc8inx 8510 34 the the DT cord-010092-uftc8inx 8510 35 plasma plasma NN cord-010092-uftc8inx 8510 36 units unit NNS cord-010092-uftc8inx 8510 37 . . . cord-010092-uftc8inx 8511 1 In in IN cord-010092-uftc8inx 8511 2 hold hold NN cord-010092-uftc8inx 8511 3 samples sample NNS cord-010092-uftc8inx 8511 4 , , , cord-010092-uftc8inx 8511 5 a a DT cord-010092-uftc8inx 8511 6 MCMV MCMV NNP cord-010092-uftc8inx 8511 7 titer titer NN cord-010092-uftc8inx 8511 8 of of IN cord-010092-uftc8inx 8511 9 3.8 3.8 CD cord-010092-uftc8inx 8511 10 ( ( -LRB- cord-010092-uftc8inx 8511 11 bag bag NN cord-010092-uftc8inx 8511 12 no no NN cord-010092-uftc8inx 8511 13 . . NN cord-010092-uftc8inx 8511 14 1 1 CD cord-010092-uftc8inx 8511 15 and and CC cord-010092-uftc8inx 8511 16 bag bag VB cord-010092-uftc8inx 8511 17 no no NN cord-010092-uftc8inx 8511 18 . . NN cord-010092-uftc8inx 8511 19 2 2 LS cord-010092-uftc8inx 8511 20 ) ) -RRB- cord-010092-uftc8inx 8511 21 log log VB cord-010092-uftc8inx 8511 22 10 10 CD cord-010092-uftc8inx 8511 23 TCID TCID NNP cord-010092-uftc8inx 8511 24 50 50 CD cord-010092-uftc8inx 8511 25 /mL /mL : cord-010092-uftc8inx 8511 26 was be VBD cord-010092-uftc8inx 8511 27 determined determine VBN cord-010092-uftc8inx 8511 28 . . . cord-010092-uftc8inx 8512 1 The the DT cord-010092-uftc8inx 8512 2 illumination illumination NN cord-010092-uftc8inx 8512 3 step step NN cord-010092-uftc8inx 8512 4 of of IN cord-010092-uftc8inx 8512 5 the the DT cord-010092-uftc8inx 8512 6 THERAFLEX THERAFLEX NNP cord-010092-uftc8inx 8512 7 MB MB NNP cord-010092-uftc8inx 8512 8 - - HYPH cord-010092-uftc8inx 8512 9 Plasma plasma NN cord-010092-uftc8inx 8512 10 treatment treatment NN cord-010092-uftc8inx 8512 11 procedure procedure NN cord-010092-uftc8inx 8512 12 efficiently efficiently RB cord-010092-uftc8inx 8512 13 inactivated inactivate VBD cord-010092-uftc8inx 8512 14 MCMV MCMV NNP cord-010092-uftc8inx 8512 15 . . . cord-010092-uftc8inx 8513 1 Already already RB cord-010092-uftc8inx 8513 2 three three CD cord-010092-uftc8inx 8513 3 - - HYPH cord-010092-uftc8inx 8513 4 fourths fourth NNS cord-010092-uftc8inx 8513 5 of of IN cord-010092-uftc8inx 8513 6 the the DT cord-010092-uftc8inx 8513 7 standard standard JJ cord-010092-uftc8inx 8513 8 light light JJ cord-010092-uftc8inx 8513 9 dose dose NN cord-010092-uftc8inx 8513 10 decreased decrease VBD cord-010092-uftc8inx 8513 11 infectivity infectivity NN cord-010092-uftc8inx 8513 12 of of IN cord-010092-uftc8inx 8513 13 cell cell NN cord-010092-uftc8inx 8513 14 associated associate VBN cord-010092-uftc8inx 8513 15 and and CC cord-010092-uftc8inx 8513 16 remaining remain VBG cord-010092-uftc8inx 8513 17 cell cell NN cord-010092-uftc8inx 8513 18 - - HYPH cord-010092-uftc8inx 8513 19 free free JJ cord-010092-uftc8inx 8513 20 MCMV mcmv NN cord-010092-uftc8inx 8513 21 to to IN cord-010092-uftc8inx 8513 22 infectivity infectivity NN cord-010092-uftc8inx 8513 23 levels level NNS cord-010092-uftc8inx 8513 24 below below IN cord-010092-uftc8inx 8513 25 the the DT cord-010092-uftc8inx 8513 26 limit limit NN cord-010092-uftc8inx 8513 27 of of IN cord-010092-uftc8inx 8513 28 detection detection NN cord-010092-uftc8inx 8513 29 ( ( -LRB- cord-010092-uftc8inx 8513 30 ≥ ≥ CD cord-010092-uftc8inx 8513 31 2.9 2.9 CD cord-010092-uftc8inx 8513 32 log log NN cord-010092-uftc8inx 8513 33 ) ) -RRB- cord-010092-uftc8inx 8513 34 . . . cord-010092-uftc8inx 8514 1 Further further JJ cord-010092-uftc8inx 8514 2 investigations investigation NNS cord-010092-uftc8inx 8514 3 would would MD cord-010092-uftc8inx 8514 4 be be VB cord-010092-uftc8inx 8514 5 needed need VBN cord-010092-uftc8inx 8514 6 to to TO cord-010092-uftc8inx 8514 7 evaluate evaluate VB cord-010092-uftc8inx 8514 8 the the DT cord-010092-uftc8inx 8514 9 log log NN cord-010092-uftc8inx 8514 10 reduction reduction NN cord-010092-uftc8inx 8514 11 capacity capacity NN cord-010092-uftc8inx 8514 12 of of IN cord-010092-uftc8inx 8514 13 the the DT cord-010092-uftc8inx 8514 14 Blueflex Blueflex NNP cord-010092-uftc8inx 8514 15 filtration filtration NN cord-010092-uftc8inx 8514 16 step step NN cord-010092-uftc8inx 8514 17 for for IN cord-010092-uftc8inx 8514 18 cell cell NN cord-010092-uftc8inx 8514 19 - - HYPH cord-010092-uftc8inx 8514 20 associated associate VBN cord-010092-uftc8inx 8514 21 MCMV MCMV NNP cord-010092-uftc8inx 8514 22 . . . cord-010092-uftc8inx 8515 1 Summary Summary NNP cord-010092-uftc8inx 8515 2 / / SYM cord-010092-uftc8inx 8515 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 8515 4 : : : cord-010092-uftc8inx 8516 1 The the DT cord-010092-uftc8inx 8516 2 results result NNS cord-010092-uftc8inx 8516 3 with with IN cord-010092-uftc8inx 8516 4 the the DT cord-010092-uftc8inx 8516 5 murine murine JJ cord-010092-uftc8inx 8516 6 model model NN cord-010092-uftc8inx 8516 7 virus virus NN cord-010092-uftc8inx 8516 8 suggest suggest VBP cord-010092-uftc8inx 8516 9 that that IN cord-010092-uftc8inx 8516 10 the the DT cord-010092-uftc8inx 8516 11 THERAFLEX THERAFLEX NNP cord-010092-uftc8inx 8516 12 MB MB NNP cord-010092-uftc8inx 8516 13 - - HYPH cord-010092-uftc8inx 8516 14 Plasma plasma NN cord-010092-uftc8inx 8516 15 system system NN cord-010092-uftc8inx 8516 16 is be VBZ cord-010092-uftc8inx 8516 17 an an DT cord-010092-uftc8inx 8516 18 effective effective JJ cord-010092-uftc8inx 8516 19 technology technology NN cord-010092-uftc8inx 8516 20 to to TO cord-010092-uftc8inx 8516 21 inactivate inactivate VB cord-010092-uftc8inx 8516 22 cell cell NN cord-010092-uftc8inx 8516 23 - - HYPH cord-010092-uftc8inx 8516 24 associated associate VBN cord-010092-uftc8inx 8516 25 CMV CMV NNP cord-010092-uftc8inx 8516 26 in in IN cord-010092-uftc8inx 8516 27 human human JJ cord-010092-uftc8inx 8516 28 plasma plasma NN cord-010092-uftc8inx 8516 29 units unit NNS cord-010092-uftc8inx 8516 30 . . . cord-010092-uftc8inx 8517 1 Background background NN cord-010092-uftc8inx 8517 2 : : : cord-010092-uftc8inx 8518 1 The the DT cord-010092-uftc8inx 8518 2 use use NN cord-010092-uftc8inx 8518 3 of of IN cord-010092-uftc8inx 8518 4 pathogen pathogen NN cord-010092-uftc8inx 8518 5 inactivation inactivation NN cord-010092-uftc8inx 8518 6 ( ( -LRB- cord-010092-uftc8inx 8518 7 PI PI NNP cord-010092-uftc8inx 8518 8 ) ) -RRB- cord-010092-uftc8inx 8518 9 technologies technology NNS cord-010092-uftc8inx 8518 10 for for IN cord-010092-uftc8inx 8518 11 platelet platelet NN cord-010092-uftc8inx 8518 12 concentrates concentrate NNS cord-010092-uftc8inx 8518 13 and and CC cord-010092-uftc8inx 8518 14 plasma plasma NN cord-010092-uftc8inx 8518 15 is be VBZ cord-010092-uftc8inx 8518 16 slowly slowly RB cord-010092-uftc8inx 8518 17 but but CC cord-010092-uftc8inx 8518 18 steadily steadily RB cord-010092-uftc8inx 8518 19 increasing increase VBG cord-010092-uftc8inx 8518 20 . . . cord-010092-uftc8inx 8519 1 Methods method NNS cord-010092-uftc8inx 8519 2 for for IN cord-010092-uftc8inx 8519 3 treatment treatment NN cord-010092-uftc8inx 8519 4 of of IN cord-010092-uftc8inx 8519 5 red red JJ cord-010092-uftc8inx 8519 6 blood blood NN cord-010092-uftc8inx 8519 7 cells cell NNS cord-010092-uftc8inx 8519 8 ( ( -LRB- cord-010092-uftc8inx 8519 9 RBCs rbc NNS cord-010092-uftc8inx 8519 10 ) ) -RRB- cord-010092-uftc8inx 8519 11 , , , cord-010092-uftc8inx 8519 12 the the DT cord-010092-uftc8inx 8519 13 most most RBS cord-010092-uftc8inx 8519 14 commonly commonly RB cord-010092-uftc8inx 8519 15 used use VBN cord-010092-uftc8inx 8519 16 blood blood NN cord-010092-uftc8inx 8519 17 component component NN cord-010092-uftc8inx 8519 18 , , , cord-010092-uftc8inx 8519 19 are be VBP cord-010092-uftc8inx 8519 20 still still RB cord-010092-uftc8inx 8519 21 under under IN cord-010092-uftc8inx 8519 22 development development NN cord-010092-uftc8inx 8519 23 . . . cord-010092-uftc8inx 8520 1 Aims aim VBZ cord-010092-uftc8inx 8520 2 : : : cord-010092-uftc8inx 8521 1 A a DT cord-010092-uftc8inx 8521 2 novel novel JJ cord-010092-uftc8inx 8521 3 approach approach NN cord-010092-uftc8inx 8521 4 for for IN cord-010092-uftc8inx 8521 5 PI PI NNP cord-010092-uftc8inx 8521 6 in in IN cord-010092-uftc8inx 8521 7 RBC RBC NNP cord-010092-uftc8inx 8521 8 units unit NNS cord-010092-uftc8inx 8521 9 employing employ VBG cord-010092-uftc8inx 8521 10 UVC UVC NNP cord-010092-uftc8inx 8521 11 light light NN cord-010092-uftc8inx 8521 12 was be VBD cord-010092-uftc8inx 8521 13 developed develop VBN cord-010092-uftc8inx 8521 14 . . . cord-010092-uftc8inx 8522 1 Methods method NNS cord-010092-uftc8inx 8522 2 : : : cord-010092-uftc8inx 8522 3 PI pi NN cord-010092-uftc8inx 8522 4 treatment treatment NN cord-010092-uftc8inx 8522 5 was be VBD cord-010092-uftc8inx 8522 6 applied apply VBN cord-010092-uftc8inx 8522 7 to to IN cord-010092-uftc8inx 8522 8 full full JJ cord-010092-uftc8inx 8522 9 - - HYPH cord-010092-uftc8inx 8522 10 scale scale NN cord-010092-uftc8inx 8522 11 RBC RBC NNP cord-010092-uftc8inx 8522 12 units unit NNS cord-010092-uftc8inx 8522 13 after after IN cord-010092-uftc8inx 8522 14 leukodepletion leukodepletion NN cord-010092-uftc8inx 8522 15 . . . cord-010092-uftc8inx 8523 1 The the DT cord-010092-uftc8inx 8523 2 PI pi NN cord-010092-uftc8inx 8523 3 capacity capacity NN cord-010092-uftc8inx 8523 4 of of IN cord-010092-uftc8inx 8523 5 the the DT cord-010092-uftc8inx 8523 6 UVC UVC NNP cord-010092-uftc8inx 8523 7 - - HYPH cord-010092-uftc8inx 8523 8 based base VBN cord-010092-uftc8inx 8523 9 method method NN cord-010092-uftc8inx 8523 10 was be VBD cord-010092-uftc8inx 8523 11 evaluated evaluate VBN cord-010092-uftc8inx 8523 12 by by IN cord-010092-uftc8inx 8523 13 bacteria bacteria NNS cord-010092-uftc8inx 8523 14 and and CC cord-010092-uftc8inx 8523 15 virus virus NN cord-010092-uftc8inx 8523 16 infectivity infectivity NN cord-010092-uftc8inx 8523 17 assays assay NNS cord-010092-uftc8inx 8523 18 . . . cord-010092-uftc8inx 8524 1 A a DT cord-010092-uftc8inx 8524 2 panel panel NN cord-010092-uftc8inx 8524 3 of of IN cord-010092-uftc8inx 8524 4 in in FW cord-010092-uftc8inx 8524 5 vitro vitro FW cord-010092-uftc8inx 8524 6 assays assay NNS cord-010092-uftc8inx 8524 7 to to TO cord-010092-uftc8inx 8524 8 measure measure VB cord-010092-uftc8inx 8524 9 quality quality NN cord-010092-uftc8inx 8524 10 , , , cord-010092-uftc8inx 8524 11 metabolism metabolism NN cord-010092-uftc8inx 8524 12 , , , cord-010092-uftc8inx 8524 13 functional functional JJ cord-010092-uftc8inx 8524 14 , , , cord-010092-uftc8inx 8524 15 morphologic morphologic JJ cord-010092-uftc8inx 8524 16 , , , cord-010092-uftc8inx 8524 17 and and CC cord-010092-uftc8inx 8524 18 blood blood NN cord-010092-uftc8inx 8524 19 group group NN cord-010092-uftc8inx 8524 20 serology serology NN cord-010092-uftc8inx 8524 21 variables variable NNS cord-010092-uftc8inx 8524 22 was be VBD cord-010092-uftc8inx 8524 23 applied apply VBN cord-010092-uftc8inx 8524 24 to to IN cord-010092-uftc8inx 8524 25 a a DT cord-010092-uftc8inx 8524 26 pool pool NN cord-010092-uftc8inx 8524 27 - - HYPH cord-010092-uftc8inx 8524 28 and and CC cord-010092-uftc8inx 8524 29 - - HYPH cord-010092-uftc8inx 8524 30 split split NN cord-010092-uftc8inx 8524 31 approach approach NN cord-010092-uftc8inx 8524 32 in in IN cord-010092-uftc8inx 8524 33 which which WDT cord-010092-uftc8inx 8524 34 pathogen pathogen NN cord-010092-uftc8inx 8524 35 - - HYPH cord-010092-uftc8inx 8524 36 reduced reduce VBN cord-010092-uftc8inx 8524 37 RBCs rbc NNS cord-010092-uftc8inx 8524 38 were be VBD cord-010092-uftc8inx 8524 39 investigated investigate VBN cord-010092-uftc8inx 8524 40 in in IN cord-010092-uftc8inx 8524 41 comparison comparison NN cord-010092-uftc8inx 8524 42 to to IN cord-010092-uftc8inx 8524 43 untreated untreated JJ cord-010092-uftc8inx 8524 44 RBCs rbc NNS cord-010092-uftc8inx 8524 45 . . . cord-010092-uftc8inx 8525 1 Results result NNS cord-010092-uftc8inx 8525 2 : : : cord-010092-uftc8inx 8526 1 UVC UVC NNP cord-010092-uftc8inx 8526 2 treatment treatment NN cord-010092-uftc8inx 8526 3 caused cause VBD cord-010092-uftc8inx 8526 4 dose dose NN cord-010092-uftc8inx 8526 5 - - HYPH cord-010092-uftc8inx 8526 6 dependent dependent JJ cord-010092-uftc8inx 8526 7 inactivation inactivation NN cord-010092-uftc8inx 8526 8 of of IN cord-010092-uftc8inx 8526 9 bacteria bacteria NNS cord-010092-uftc8inx 8526 10 and and CC cord-010092-uftc8inx 8526 11 enveloped envelop VBN cord-010092-uftc8inx 8526 12 and and CC cord-010092-uftc8inx 8526 13 non non JJ cord-010092-uftc8inx 8526 14 - - JJ cord-010092-uftc8inx 8526 15 enveloped enveloped JJ cord-010092-uftc8inx 8526 16 viruses virus NNS cord-010092-uftc8inx 8526 17 in in IN cord-010092-uftc8inx 8526 18 RBC RBC NNP cord-010092-uftc8inx 8526 19 units unit NNS cord-010092-uftc8inx 8526 20 . . . cord-010092-uftc8inx 8527 1 At at IN cord-010092-uftc8inx 8527 2 a a DT cord-010092-uftc8inx 8527 3 full full JJ cord-010092-uftc8inx 8527 4 dose dose NN cord-010092-uftc8inx 8527 5 , , , cord-010092-uftc8inx 8527 6 the the DT cord-010092-uftc8inx 8527 7 mean mean NN cord-010092-uftc8inx 8527 8 log log NN cord-010092-uftc8inx 8527 9 10 10 CD cord-010092-uftc8inx 8527 10 reduction reduction NN cord-010092-uftc8inx 8527 11 factors factor NNS cord-010092-uftc8inx 8527 12 ranged range VBD cord-010092-uftc8inx 8527 13 from from IN cord-010092-uftc8inx 8527 14 4.2 4.2 CD cord-010092-uftc8inx 8527 15 ( ( -LRB- cord-010092-uftc8inx 8527 16 Bacillus bacillus NN cord-010092-uftc8inx 8527 17 cereus cereus NN cord-010092-uftc8inx 8527 18 ) ) -RRB- cord-010092-uftc8inx 8527 19 to to IN cord-010092-uftc8inx 8527 20 6.1 6.1 CD cord-010092-uftc8inx 8527 21 ( ( -LRB- cord-010092-uftc8inx 8527 22 Serratia Serratia NNP cord-010092-uftc8inx 8527 23 liquefaciens liquefacien NNS cord-010092-uftc8inx 8527 24 ) ) -RRB- cord-010092-uftc8inx 8527 25 for for IN cord-010092-uftc8inx 8527 26 the the DT cord-010092-uftc8inx 8527 27 tested test VBN cord-010092-uftc8inx 8527 28 bacteria bacteria NNS cord-010092-uftc8inx 8527 29 , , , cord-010092-uftc8inx 8527 30 and and CC cord-010092-uftc8inx 8527 31 from from IN cord-010092-uftc8inx 8527 32 3.1 3.1 CD cord-010092-uftc8inx 8527 33 ( ( -LRB- cord-010092-uftc8inx 8527 34 EMCV EMCV NNP cord-010092-uftc8inx 8527 35 ) ) -RRB- cord-010092-uftc8inx 8527 36 to to IN cord-010092-uftc8inx 8527 37 ≥ ≥ CD cord-010092-uftc8inx 8527 38 4.9 4.9 CD cord-010092-uftc8inx 8527 39 ( ( -LRB- cord-010092-uftc8inx 8527 40 VSV VSV NNP cord-010092-uftc8inx 8527 41 ) ) -RRB- cord-010092-uftc8inx 8527 42 for for IN cord-010092-uftc8inx 8527 43 the the DT cord-010092-uftc8inx 8527 44 tested test VBN cord-010092-uftc8inx 8527 45 viruses virus NNS cord-010092-uftc8inx 8527 46 . . . cord-010092-uftc8inx 8528 1 UVC UVC NNP cord-010092-uftc8inx 8528 2 treatment treatment NN cord-010092-uftc8inx 8528 3 did do VBD cord-010092-uftc8inx 8528 4 not not RB cord-010092-uftc8inx 8528 5 alter alter VB cord-010092-uftc8inx 8528 6 RBC RBC NNP cord-010092-uftc8inx 8528 7 blood blood NN cord-010092-uftc8inx 8528 8 group group NN cord-010092-uftc8inx 8528 9 antigen antigen NN cord-010092-uftc8inx 8528 10 expression expression NN cord-010092-uftc8inx 8528 11 . . . cord-010092-uftc8inx 8529 1 Quality quality NN cord-010092-uftc8inx 8529 2 of of IN cord-010092-uftc8inx 8529 3 UVC UVC NNP cord-010092-uftc8inx 8529 4 - - HYPH cord-010092-uftc8inx 8529 5 treated treat VBN cord-010092-uftc8inx 8529 6 RBCs rbc NNS cord-010092-uftc8inx 8529 7 was be VBD cord-010092-uftc8inx 8529 8 maintained maintain VBN cord-010092-uftc8inx 8529 9 during during IN cord-010092-uftc8inx 8529 10 storage storage NN cord-010092-uftc8inx 8529 11 , , , cord-010092-uftc8inx 8529 12 e.g. e.g. JJ cord-010092-uftc8inx 8529 13 hemolysis hemolysis NN cord-010092-uftc8inx 8529 14 in in IN cord-010092-uftc8inx 8529 15 UVC UVC NNP cord-010092-uftc8inx 8529 16 - - HYPH cord-010092-uftc8inx 8529 17 treated treat VBN cord-010092-uftc8inx 8529 18 and and CC cord-010092-uftc8inx 8529 19 untreated untreated JJ cord-010092-uftc8inx 8529 20 RBCs rbc NNS cord-010092-uftc8inx 8529 21 were be VBD cord-010092-uftc8inx 8529 22 well well RB cord-010092-uftc8inx 8529 23 below below IN cord-010092-uftc8inx 8529 24 0.8 0.8 CD cord-010092-uftc8inx 8529 25 % % NN cord-010092-uftc8inx 8529 26 until until IN cord-010092-uftc8inx 8529 27 day day NN cord-010092-uftc8inx 8529 28 35 35 CD cord-010092-uftc8inx 8529 29 of of IN cord-010092-uftc8inx 8529 30 storage storage NN cord-010092-uftc8inx 8529 31 . . . cord-010092-uftc8inx 8530 1 Summary Summary NNP cord-010092-uftc8inx 8530 2 / / SYM cord-010092-uftc8inx 8530 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 8530 4 : : : cord-010092-uftc8inx 8531 1 The the DT cord-010092-uftc8inx 8531 2 data datum NNS cord-010092-uftc8inx 8531 3 obtained obtain VBN cord-010092-uftc8inx 8531 4 until until IN cord-010092-uftc8inx 8531 5 now now RB cord-010092-uftc8inx 8531 6 show show VBP cord-010092-uftc8inx 8531 7 that that IN cord-010092-uftc8inx 8531 8 UVC UVC NNP cord-010092-uftc8inx 8531 9 irradiation irradiation NN cord-010092-uftc8inx 8531 10 is be VBZ cord-010092-uftc8inx 8531 11 a a DT cord-010092-uftc8inx 8531 12 potential potential JJ cord-010092-uftc8inx 8531 13 new new JJ cord-010092-uftc8inx 8531 14 method method NN cord-010092-uftc8inx 8531 15 for for IN cord-010092-uftc8inx 8531 16 PI pi NN cord-010092-uftc8inx 8531 17 in in IN cord-010092-uftc8inx 8531 18 RBCs rbc NNS cord-010092-uftc8inx 8531 19 and and CC cord-010092-uftc8inx 8531 20 justify justify VB cord-010092-uftc8inx 8531 21 further further JJ cord-010092-uftc8inx 8531 22 development development NN cord-010092-uftc8inx 8531 23 of of IN cord-010092-uftc8inx 8531 24 this this DT cord-010092-uftc8inx 8531 25 process process NN cord-010092-uftc8inx 8531 26 . . . cord-010092-uftc8inx 8532 1 Background background NN cord-010092-uftc8inx 8532 2 : : : cord-010092-uftc8inx 8533 1 Histo Histo NNP cord-010092-uftc8inx 8533 2 - - HYPH cord-010092-uftc8inx 8533 3 Blood blood NN cord-010092-uftc8inx 8533 4 ABH ABH NNP cord-010092-uftc8inx 8533 5 antigens antigen NNS cord-010092-uftc8inx 8533 6 are be VBP cord-010092-uftc8inx 8533 7 the the DT cord-010092-uftc8inx 8533 8 mayor mayor NN cord-010092-uftc8inx 8533 9 allogeneic allogeneic NN cord-010092-uftc8inx 8533 10 antigens antigen NNS cord-010092-uftc8inx 8533 11 in in IN cord-010092-uftc8inx 8533 12 human human NN cord-010092-uftc8inx 8533 13 and and CC cord-010092-uftc8inx 8533 14 they -PRON- PRP cord-010092-uftc8inx 8533 15 are be VBP cord-010092-uftc8inx 8533 16 widely widely RB cord-010092-uftc8inx 8533 17 distributed distribute VBN cord-010092-uftc8inx 8533 18 in in IN cord-010092-uftc8inx 8533 19 almost almost RB cord-010092-uftc8inx 8533 20 all all DT cord-010092-uftc8inx 8533 21 tissues tissue NNS cord-010092-uftc8inx 8533 22 . . . cord-010092-uftc8inx 8534 1 The the DT cord-010092-uftc8inx 8534 2 expression expression NN cord-010092-uftc8inx 8534 3 of of IN cord-010092-uftc8inx 8534 4 a-1,2-fucosyltransferase a-1,2-fucosyltransferase NNP cord-010092-uftc8inx 8534 5 ( ( -LRB- cord-010092-uftc8inx 8534 6 FucT2 FucT2 NNP cord-010092-uftc8inx 8534 7 ) ) -RRB- cord-010092-uftc8inx 8534 8 , , , cord-010092-uftc8inx 8534 9 encoded encode VBN cord-010092-uftc8inx 8534 10 by by IN cord-010092-uftc8inx 8534 11 FUT2 FUT2 NNP cord-010092-uftc8inx 8534 12 gene gene NN cord-010092-uftc8inx 8534 13 , , , cord-010092-uftc8inx 8534 14 determines determine VBZ cord-010092-uftc8inx 8534 15 the the DT cord-010092-uftc8inx 8534 16 secretor secretor NN cord-010092-uftc8inx 8534 17 status status NN cord-010092-uftc8inx 8534 18 of of IN cord-010092-uftc8inx 8534 19 an an DT cord-010092-uftc8inx 8534 20 individual individual NN cord-010092-uftc8inx 8534 21 . . . cord-010092-uftc8inx 8535 1 About about RB cord-010092-uftc8inx 8535 2 80 80 CD cord-010092-uftc8inx 8535 3 % % NN cord-010092-uftc8inx 8535 4 of of IN cord-010092-uftc8inx 8535 5 Caucasian caucasian JJ cord-010092-uftc8inx 8535 6 population population NN cord-010092-uftc8inx 8535 7 have have VBP cord-010092-uftc8inx 8535 8 a a DT cord-010092-uftc8inx 8535 9 functional functional JJ cord-010092-uftc8inx 8535 10 copy copy NN cord-010092-uftc8inx 8535 11 of of IN cord-010092-uftc8inx 8535 12 FUT2 FUT2 NNP cord-010092-uftc8inx 8535 13 ( ( -LRB- cord-010092-uftc8inx 8535 14 secretor secretor NNP cord-010092-uftc8inx 8535 15 gene gene NN cord-010092-uftc8inx 8535 16 ) ) -RRB- cord-010092-uftc8inx 8535 17 expressing express VBG cord-010092-uftc8inx 8535 18 ABH ABH NNP cord-010092-uftc8inx 8535 19 blood blood NN cord-010092-uftc8inx 8535 20 group group NN cord-010092-uftc8inx 8535 21 soluble soluble JJ cord-010092-uftc8inx 8535 22 antigens antigen NNS cord-010092-uftc8inx 8535 23 in in IN cord-010092-uftc8inx 8535 24 organic organic JJ cord-010092-uftc8inx 8535 25 fluids fluid NNS cord-010092-uftc8inx 8535 26 such such JJ cord-010092-uftc8inx 8535 27 as as IN cord-010092-uftc8inx 8535 28 saliva saliva NN cord-010092-uftc8inx 8535 29 and and CC cord-010092-uftc8inx 8535 30 seminal seminal JJ cord-010092-uftc8inx 8535 31 plasma plasma NN cord-010092-uftc8inx 8535 32 . . . cord-010092-uftc8inx 8536 1 This this DT cord-010092-uftc8inx 8536 2 individuals individual NNS cord-010092-uftc8inx 8536 3 are be VBP cord-010092-uftc8inx 8536 4 known know VBN cord-010092-uftc8inx 8536 5 as as IN cord-010092-uftc8inx 8536 6 " " `` cord-010092-uftc8inx 8536 7 secretors secretor NNS cord-010092-uftc8inx 8536 8 " " '' cord-010092-uftc8inx 8536 9 . . . cord-010092-uftc8inx 8537 1 Soluble soluble JJ cord-010092-uftc8inx 8537 2 ABH ABH NNP cord-010092-uftc8inx 8537 3 blood blood NN cord-010092-uftc8inx 8537 4 group group NN cord-010092-uftc8inx 8537 5 antigens antigen NNS cord-010092-uftc8inx 8537 6 have have VBP cord-010092-uftc8inx 8537 7 been be VBN cord-010092-uftc8inx 8537 8 associated associate VBN cord-010092-uftc8inx 8537 9 with with IN cord-010092-uftc8inx 8537 10 several several JJ cord-010092-uftc8inx 8537 11 metabolic metabolic JJ cord-010092-uftc8inx 8537 12 and and CC cord-010092-uftc8inx 8537 13 infectious infectious JJ cord-010092-uftc8inx 8537 14 diseases disease NNS cord-010092-uftc8inx 8537 15 as as RB cord-010092-uftc8inx 8537 16 well well RB cord-010092-uftc8inx 8537 17 as as IN cord-010092-uftc8inx 8537 18 reproductive reproductive JJ cord-010092-uftc8inx 8537 19 failures failure NNS cord-010092-uftc8inx 8537 20 . . . cord-010092-uftc8inx 8538 1 The the DT cord-010092-uftc8inx 8538 2 incidence incidence NN cord-010092-uftc8inx 8538 3 of of IN cord-010092-uftc8inx 8538 4 infertility infertility NN cord-010092-uftc8inx 8538 5 related relate VBN cord-010092-uftc8inx 8538 6 of of IN cord-010092-uftc8inx 8538 7 both both DT cord-010092-uftc8inx 8538 8 male male JJ cord-010092-uftc8inx 8538 9 and and CC cord-010092-uftc8inx 8538 10 female female JJ cord-010092-uftc8inx 8538 11 factors factor NNS cord-010092-uftc8inx 8538 12 continues continue VBZ cord-010092-uftc8inx 8538 13 to to TO cord-010092-uftc8inx 8538 14 rise rise VB cord-010092-uftc8inx 8538 15 despite despite IN cord-010092-uftc8inx 8538 16 many many JJ cord-010092-uftc8inx 8538 17 advances advance NNS cord-010092-uftc8inx 8538 18 in in IN cord-010092-uftc8inx 8538 19 reproductive reproductive JJ cord-010092-uftc8inx 8538 20 technologies technology NNS cord-010092-uftc8inx 8538 21 . . . cord-010092-uftc8inx 8539 1 It -PRON- PRP cord-010092-uftc8inx 8539 2 is be VBZ cord-010092-uftc8inx 8539 3 well well RB cord-010092-uftc8inx 8539 4 known know VBN cord-010092-uftc8inx 8539 5 that that IN cord-010092-uftc8inx 8539 6 ABO ABO NNP cord-010092-uftc8inx 8539 7 antigens antigen NNS cord-010092-uftc8inx 8539 8 are be VBP cord-010092-uftc8inx 8539 9 expressed express VBN cord-010092-uftc8inx 8539 10 on on IN cord-010092-uftc8inx 8539 11 sperm sperm NN cord-010092-uftc8inx 8539 12 membrane membrane NN cord-010092-uftc8inx 8539 13 and and CC cord-010092-uftc8inx 8539 14 in in IN cord-010092-uftc8inx 8539 15 seminal seminal JJ cord-010092-uftc8inx 8539 16 fluid fluid NN cord-010092-uftc8inx 8539 17 of of IN cord-010092-uftc8inx 8539 18 secretors secretor NNS cord-010092-uftc8inx 8539 19 as as RB cord-010092-uftc8inx 8539 20 well well RB cord-010092-uftc8inx 8539 21 as as IN cord-010092-uftc8inx 8539 22 ABO ABO NNP cord-010092-uftc8inx 8539 23 antibodies antibody NNS cord-010092-uftc8inx 8539 24 are be VBP cord-010092-uftc8inx 8539 25 present present JJ cord-010092-uftc8inx 8539 26 in in IN cord-010092-uftc8inx 8539 27 cervical cervical JJ cord-010092-uftc8inx 8539 28 mucus mucus NN cord-010092-uftc8inx 8539 29 . . . cord-010092-uftc8inx 8540 1 In in IN cord-010092-uftc8inx 8540 2 previous previous JJ cord-010092-uftc8inx 8540 3 studies study NNS cord-010092-uftc8inx 8540 4 we -PRON- PRP cord-010092-uftc8inx 8540 5 observed observe VBD cord-010092-uftc8inx 8540 6 significant significant JJ cord-010092-uftc8inx 8540 7 loss loss NN cord-010092-uftc8inx 8540 8 in in IN cord-010092-uftc8inx 8540 9 progressive progressive JJ cord-010092-uftc8inx 8540 10 motility motility NN cord-010092-uftc8inx 8540 11 of of IN cord-010092-uftc8inx 8540 12 spermatozoa spermatozoon NNS cord-010092-uftc8inx 8540 13 of of IN cord-010092-uftc8inx 8540 14 non non JJ cord-010092-uftc8inx 8540 15 - - NNS cord-010092-uftc8inx 8540 16 secretors secretor NNS cord-010092-uftc8inx 8540 17 compared compare VBN cord-010092-uftc8inx 8540 18 to to IN cord-010092-uftc8inx 8540 19 secretor secretor NNP cord-010092-uftc8inx 8540 20 ones one NNS cord-010092-uftc8inx 8540 21 caused cause VBN cord-010092-uftc8inx 8540 22 by by IN cord-010092-uftc8inx 8540 23 specific specific JJ cord-010092-uftc8inx 8540 24 cervical cervical JJ cord-010092-uftc8inx 8540 25 mucus mucus NN cord-010092-uftc8inx 8540 26 antibodies antibody NNS cord-010092-uftc8inx 8540 27 in in IN cord-010092-uftc8inx 8540 28 ABO ABO NNP cord-010092-uftc8inx 8540 29 - - HYPH cord-010092-uftc8inx 8540 30 incompatible incompatible JJ cord-010092-uftc8inx 8540 31 couples couple NNS cord-010092-uftc8inx 8540 32 . . . cord-010092-uftc8inx 8541 1 In in IN cord-010092-uftc8inx 8541 2 addition addition NN cord-010092-uftc8inx 8541 3 , , , cord-010092-uftc8inx 8541 4 sperm sperm NN cord-010092-uftc8inx 8541 5 cells cell NNS cord-010092-uftc8inx 8541 6 are be VBP cord-010092-uftc8inx 8541 7 haploid haploid JJ cord-010092-uftc8inx 8541 8 cells cell NNS cord-010092-uftc8inx 8541 9 , , , cord-010092-uftc8inx 8541 10 so so IN cord-010092-uftc8inx 8541 11 that that IN cord-010092-uftc8inx 8541 12 a a DT cord-010092-uftc8inx 8541 13 heterozygous heterozygous JJ cord-010092-uftc8inx 8541 14 individual individual NN cord-010092-uftc8inx 8541 15 has have VBZ cord-010092-uftc8inx 8541 16 two two CD cord-010092-uftc8inx 8541 17 sperm sperm NN cord-010092-uftc8inx 8541 18 subpopulations subpopulation NNS cord-010092-uftc8inx 8541 19 , , , cord-010092-uftc8inx 8541 20 each each DT cord-010092-uftc8inx 8541 21 expressing express VBG cord-010092-uftc8inx 8541 22 the the DT cord-010092-uftc8inx 8541 23 corresponding correspond VBG cord-010092-uftc8inx 8541 24 allele allele NN cord-010092-uftc8inx 8541 25 . . . cord-010092-uftc8inx 8542 1 The the DT cord-010092-uftc8inx 8542 2 specific specific JJ cord-010092-uftc8inx 8542 3 antibody antibody NN cord-010092-uftc8inx 8542 4 of of IN cord-010092-uftc8inx 8542 5 cervical cervical JJ cord-010092-uftc8inx 8542 6 mucus mucus NN cord-010092-uftc8inx 8542 7 will will MD cord-010092-uftc8inx 8542 8 attack attack VB cord-010092-uftc8inx 8542 9 only only RB cord-010092-uftc8inx 8542 10 its -PRON- PRP$ cord-010092-uftc8inx 8542 11 complementary complementary JJ cord-010092-uftc8inx 8542 12 sperm sperm NN cord-010092-uftc8inx 8542 13 . . . cord-010092-uftc8inx 8543 1 Aims aim VBZ cord-010092-uftc8inx 8543 2 : : : cord-010092-uftc8inx 8543 3 To to TO cord-010092-uftc8inx 8543 4 evaluate evaluate VB cord-010092-uftc8inx 8543 5 the the DT cord-010092-uftc8inx 8543 6 prevalence prevalence NN cord-010092-uftc8inx 8543 7 of of IN cord-010092-uftc8inx 8543 8 secretor secretor NN cord-010092-uftc8inx 8543 9 character character NN cord-010092-uftc8inx 8543 10 in in IN cord-010092-uftc8inx 8543 11 men man NNS cord-010092-uftc8inx 8543 12 belonging belong VBG cord-010092-uftc8inx 8543 13 to to IN cord-010092-uftc8inx 8543 14 fertile fertile JJ cord-010092-uftc8inx 8543 15 and and CC cord-010092-uftc8inx 8543 16 infertile infertile JJ cord-010092-uftc8inx 8543 17 couples couple NNS cord-010092-uftc8inx 8543 18 in in IN cord-010092-uftc8inx 8543 19 order order NN cord-010092-uftc8inx 8543 20 to to TO cord-010092-uftc8inx 8543 21 investigate investigate VB cord-010092-uftc8inx 8543 22 a a DT cord-010092-uftc8inx 8543 23 possible possible JJ cord-010092-uftc8inx 8543 24 association association NN cord-010092-uftc8inx 8543 25 with with IN cord-010092-uftc8inx 8543 26 reproductive reproductive JJ cord-010092-uftc8inx 8543 27 success success NN cord-010092-uftc8inx 8543 28 . . . cord-010092-uftc8inx 8544 1 Methods method NNS cord-010092-uftc8inx 8544 2 : : : cord-010092-uftc8inx 8544 3 126 126 CD cord-010092-uftc8inx 8544 4 samples sample NNS cord-010092-uftc8inx 8544 5 of of IN cord-010092-uftc8inx 8544 6 semen semen NN cord-010092-uftc8inx 8544 7 , , , cord-010092-uftc8inx 8544 8 68 68 CD cord-010092-uftc8inx 8544 9 from from IN cord-010092-uftc8inx 8544 10 infertile infertile JJ cord-010092-uftc8inx 8544 11 men man NNS cord-010092-uftc8inx 8544 12 and and CC cord-010092-uftc8inx 8544 13 58 58 CD cord-010092-uftc8inx 8544 14 from from IN cord-010092-uftc8inx 8544 15 fertile fertile JJ cord-010092-uftc8inx 8544 16 controls control NNS cord-010092-uftc8inx 8544 17 were be VBD cord-010092-uftc8inx 8544 18 studied study VBN cord-010092-uftc8inx 8544 19 . . . cord-010092-uftc8inx 8545 1 Comprehensive comprehensive JJ cord-010092-uftc8inx 8545 2 infertility infertility NN cord-010092-uftc8inx 8545 3 evaluation evaluation NN cord-010092-uftc8inx 8545 4 was be VBD cord-010092-uftc8inx 8545 5 performed perform VBN cord-010092-uftc8inx 8545 6 in in IN cord-010092-uftc8inx 8545 7 all all DT cord-010092-uftc8inx 8545 8 patients patient NNS cord-010092-uftc8inx 8545 9 according accord VBG cord-010092-uftc8inx 8545 10 to to IN cord-010092-uftc8inx 8545 11 WHO who WP cord-010092-uftc8inx 8545 12 2010 2010 CD cord-010092-uftc8inx 8545 13 criteria criterion NNS cord-010092-uftc8inx 8545 14 . . . cord-010092-uftc8inx 8546 1 Secretor Secretor NNP cord-010092-uftc8inx 8546 2 phenotype phenotype NN cord-010092-uftc8inx 8546 3 was be VBD cord-010092-uftc8inx 8546 4 evaluated evaluate VBN cord-010092-uftc8inx 8546 5 in in IN cord-010092-uftc8inx 8546 6 seminal seminal JJ cord-010092-uftc8inx 8546 7 plasma plasma NN cord-010092-uftc8inx 8546 8 by by IN cord-010092-uftc8inx 8546 9 inhibition inhibition NN cord-010092-uftc8inx 8546 10 of of IN cord-010092-uftc8inx 8546 11 hemagglutination hemagglutination NN cord-010092-uftc8inx 8546 12 assay assay NN cord-010092-uftc8inx 8546 13 using use VBG cord-010092-uftc8inx 8546 14 saline saline NN cord-010092-uftc8inx 8546 15 erythrocyte erythrocyte NN cord-010092-uftc8inx 8546 16 suspensions suspension NNS cord-010092-uftc8inx 8546 17 , , , cord-010092-uftc8inx 8546 18 monoclonal monoclonal JJ cord-010092-uftc8inx 8546 19 antibodies antibody NNS cord-010092-uftc8inx 8546 20 anti anti VBP cord-010092-uftc8inx 8546 21 - - NNP cord-010092-uftc8inx 8546 22 A a JJ cord-010092-uftc8inx 8546 23 , , , cord-010092-uftc8inx 8546 24 anti anti NN cord-010092-uftc8inx 8546 25 - - NN cord-010092-uftc8inx 8546 26 B b NN cord-010092-uftc8inx 8546 27 and and CC cord-010092-uftc8inx 8546 28 lectin lectin NN cord-010092-uftc8inx 8546 29 from from IN cord-010092-uftc8inx 8546 30 Ulex Ulex NNP cord-010092-uftc8inx 8546 31 europaeus europaeus NN cord-010092-uftc8inx 8546 32 ( ( -LRB- cord-010092-uftc8inx 8546 33 Anti Anti NNP cord-010092-uftc8inx 8546 34 - - NNP cord-010092-uftc8inx 8546 35 H H NNP cord-010092-uftc8inx 8546 36 ) ) -RRB- cord-010092-uftc8inx 8546 37 . . . cord-010092-uftc8inx 8547 1 To to TO cord-010092-uftc8inx 8547 2 distinguish distinguish VB cord-010092-uftc8inx 8547 3 between between IN cord-010092-uftc8inx 8547 4 ABO ABO NNP cord-010092-uftc8inx 8547 5 genes gene NNS cord-010092-uftc8inx 8547 6 , , , cord-010092-uftc8inx 8547 7 genomic genomic JJ cord-010092-uftc8inx 8547 8 DNA dna NN cord-010092-uftc8inx 8547 9 was be VBD cord-010092-uftc8inx 8547 10 extracted extract VBN cord-010092-uftc8inx 8547 11 by by IN cord-010092-uftc8inx 8547 12 an an DT cord-010092-uftc8inx 8547 13 enzymatic enzymatic JJ cord-010092-uftc8inx 8547 14 digestion digestion NN cord-010092-uftc8inx 8547 15 method method NN cord-010092-uftc8inx 8547 16 . . . cord-010092-uftc8inx 8548 1 PCR PCR NNP cord-010092-uftc8inx 8548 2 was be VBD cord-010092-uftc8inx 8548 3 designed design VBN cord-010092-uftc8inx 8548 4 with with IN cord-010092-uftc8inx 8548 5 two two CD cord-010092-uftc8inx 8548 6 sets set NNS cord-010092-uftc8inx 8548 7 of of IN cord-010092-uftc8inx 8548 8 oligonucleotides oligonucleotide NNS cord-010092-uftc8inx 8548 9 that that WDT cord-010092-uftc8inx 8548 10 allow allow VBP cord-010092-uftc8inx 8548 11 to to IN cord-010092-uftc8inx 8548 12 amplificate amplificate VB cord-010092-uftc8inx 8548 13 two two CD cord-010092-uftc8inx 8548 14 different different JJ cord-010092-uftc8inx 8548 15 regions region NNS cord-010092-uftc8inx 8548 16 of of IN cord-010092-uftc8inx 8548 17 the the DT cord-010092-uftc8inx 8548 18 transferases transferase NNS cord-010092-uftc8inx 8548 19 without without IN cord-010092-uftc8inx 8548 20 use use NN cord-010092-uftc8inx 8548 21 of of IN cord-010092-uftc8inx 8548 22 restriction restriction NN cord-010092-uftc8inx 8548 23 enzymes enzyme NNS cord-010092-uftc8inx 8548 24 . . . cord-010092-uftc8inx 8549 1 By by IN cord-010092-uftc8inx 8549 2 comparison comparison NN cord-010092-uftc8inx 8549 3 of of IN cord-010092-uftc8inx 8549 4 bands band NNS cord-010092-uftc8inx 8549 5 of of IN cord-010092-uftc8inx 8549 6 the the DT cord-010092-uftc8inx 8549 7 PCR PCR NNP cord-010092-uftc8inx 8549 8 products product NNS cord-010092-uftc8inx 8549 9 , , , cord-010092-uftc8inx 8549 10 the the DT cord-010092-uftc8inx 8549 11 individual individual JJ cord-010092-uftc8inx 8549 12 genotype genotype NN cord-010092-uftc8inx 8549 13 was be VBD cord-010092-uftc8inx 8549 14 determine determine NN cord-010092-uftc8inx 8549 15 . . . cord-010092-uftc8inx 8550 1 Cervical cervical JJ cord-010092-uftc8inx 8550 2 mucus mucus NN cord-010092-uftc8inx 8550 3 antibodies antibody NNS cord-010092-uftc8inx 8550 4 of of IN cord-010092-uftc8inx 8550 5 their -PRON- PRP$ cord-010092-uftc8inx 8550 6 female female JJ cord-010092-uftc8inx 8550 7 partners partner NNS cord-010092-uftc8inx 8550 8 were be VBD cord-010092-uftc8inx 8550 9 titrated titrate VBN cord-010092-uftc8inx 8550 10 with with IN cord-010092-uftc8inx 8550 11 the the DT cord-010092-uftc8inx 8550 12 corresponding corresponding JJ cord-010092-uftc8inx 8550 13 red red JJ cord-010092-uftc8inx 8550 14 blood blood NN cord-010092-uftc8inx 8550 15 cells cell NNS cord-010092-uftc8inx 8550 16 . . . cord-010092-uftc8inx 8551 1 Results result NNS cord-010092-uftc8inx 8551 2 : : : cord-010092-uftc8inx 8552 1 Results result NNS cord-010092-uftc8inx 8552 2 were be VBD cord-010092-uftc8inx 8552 3 analysed analyse VBN cord-010092-uftc8inx 8552 4 in in IN cord-010092-uftc8inx 8552 5 both both DT cord-010092-uftc8inx 8552 6 groups group NNS cord-010092-uftc8inx 8552 7 . . . cord-010092-uftc8inx 8553 1 In in IN cord-010092-uftc8inx 8553 2 infertile infertile JJ cord-010092-uftc8inx 8553 3 couples couple NNS cord-010092-uftc8inx 8553 4 with with IN cord-010092-uftc8inx 8553 5 ABO ABO NNP cord-010092-uftc8inx 8553 6 incompatibility incompatibility NN cord-010092-uftc8inx 8553 7 , , , cord-010092-uftc8inx 8553 8 the the DT cord-010092-uftc8inx 8553 9 frequency frequency NN cord-010092-uftc8inx 8553 10 of of IN cord-010092-uftc8inx 8553 11 non non JJ cord-010092-uftc8inx 8553 12 - - JJ cord-010092-uftc8inx 8553 13 secretor secretor JJ cord-010092-uftc8inx 8553 14 phenotype phenotype NN cord-010092-uftc8inx 8553 15 of of IN cord-010092-uftc8inx 8553 16 male male JJ cord-010092-uftc8inx 8553 17 partners partner NNS cord-010092-uftc8inx 8553 18 ( ( -LRB- cord-010092-uftc8inx 8553 19 76.9 76.9 CD cord-010092-uftc8inx 8553 20 % % NN cord-010092-uftc8inx 8553 21 ) ) -RRB- cord-010092-uftc8inx 8553 22 were be VBD cord-010092-uftc8inx 8553 23 significantly significantly RB cord-010092-uftc8inx 8553 24 higher high JJR cord-010092-uftc8inx 8553 25 than than IN cord-010092-uftc8inx 8553 26 those those DT cord-010092-uftc8inx 8553 27 from from IN cord-010092-uftc8inx 8553 28 fertile fertile JJ cord-010092-uftc8inx 8553 29 couples couple NNS cord-010092-uftc8inx 8553 30 ( ( -LRB- cord-010092-uftc8inx 8553 31 21.6 21.6 CD cord-010092-uftc8inx 8553 32 % % NN cord-010092-uftc8inx 8553 33 ) ) -RRB- cord-010092-uftc8inx 8554 1 ( ( -LRB- cord-010092-uftc8inx 8554 2 P p NN cord-010092-uftc8inx 8554 3 < < XX cord-010092-uftc8inx 8554 4 0.03 0.03 CD cord-010092-uftc8inx 8554 5 ) ) -RRB- cord-010092-uftc8inx 8555 1 The the DT cord-010092-uftc8inx 8555 2 results result NNS cord-010092-uftc8inx 8555 3 obtained obtain VBN cord-010092-uftc8inx 8555 4 by by IN cord-010092-uftc8inx 8555 5 PCR PCR NNP cord-010092-uftc8inx 8555 6 in in IN cord-010092-uftc8inx 8555 7 sperm sperm NN cord-010092-uftc8inx 8555 8 cells cell NNS cord-010092-uftc8inx 8555 9 correlated correlate VBD cord-010092-uftc8inx 8555 10 100 100 CD cord-010092-uftc8inx 8555 11 % % NN cord-010092-uftc8inx 8555 12 with with IN cord-010092-uftc8inx 8555 13 red red JJ cord-010092-uftc8inx 8555 14 cells cell NNS cord-010092-uftc8inx 8555 15 phenotypes phenotype NNS cord-010092-uftc8inx 8555 16 . . . cord-010092-uftc8inx 8556 1 Summary Summary NNP cord-010092-uftc8inx 8556 2 / / SYM cord-010092-uftc8inx 8556 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 8556 4 : : : cord-010092-uftc8inx 8557 1 Incidence incidence NN cord-010092-uftc8inx 8557 2 of of IN cord-010092-uftc8inx 8557 3 infertility infertility NN cord-010092-uftc8inx 8557 4 continues continue VBZ cord-010092-uftc8inx 8557 5 to to TO cord-010092-uftc8inx 8557 6 increase increase VB cord-010092-uftc8inx 8557 7 . . . cord-010092-uftc8inx 8558 1 Several several JJ cord-010092-uftc8inx 8558 2 factors factor NNS cord-010092-uftc8inx 8558 3 have have VBP cord-010092-uftc8inx 8558 4 a a DT cord-010092-uftc8inx 8558 5 negative negative JJ cord-010092-uftc8inx 8558 6 impact impact NN cord-010092-uftc8inx 8558 7 on on IN cord-010092-uftc8inx 8558 8 men man NNS cord-010092-uftc8inx 8558 9 's 's POS cord-010092-uftc8inx 8558 10 reproductive reproductive JJ cord-010092-uftc8inx 8558 11 health health NN cord-010092-uftc8inx 8558 12 . . . cord-010092-uftc8inx 8559 1 Immunological immunological JJ cord-010092-uftc8inx 8559 2 implications implication NNS cord-010092-uftc8inx 8559 3 are be VBP cord-010092-uftc8inx 8559 4 now now RB cord-010092-uftc8inx 8559 5 being be VBG cord-010092-uftc8inx 8559 6 studied study VBN cord-010092-uftc8inx 8559 7 and and CC cord-010092-uftc8inx 8559 8 considered consider VBN cord-010092-uftc8inx 8559 9 as as IN cord-010092-uftc8inx 8559 10 a a DT cord-010092-uftc8inx 8559 11 cause cause NN cord-010092-uftc8inx 8559 12 of of IN cord-010092-uftc8inx 8559 13 failure failure NN cord-010092-uftc8inx 8559 14 in in IN cord-010092-uftc8inx 8559 15 sperm sperm NN cord-010092-uftc8inx 8559 16 - - HYPH cord-010092-uftc8inx 8559 17 egg egg NN cord-010092-uftc8inx 8559 18 interaction interaction NN cord-010092-uftc8inx 8559 19 , , , cord-010092-uftc8inx 8559 20 even even RB cord-010092-uftc8inx 8559 21 among among IN cord-010092-uftc8inx 8559 22 normal normal JJ cord-010092-uftc8inx 8559 23 gametes gamete NNS cord-010092-uftc8inx 8559 24 . . . cord-010092-uftc8inx 8560 1 Secretor secretor NN cord-010092-uftc8inx 8560 2 phenotype phenotype NN cord-010092-uftc8inx 8560 3 in in IN cord-010092-uftc8inx 8560 4 male male JJ cord-010092-uftc8inx 8560 5 partners partner NNS cord-010092-uftc8inx 8560 6 could could MD cord-010092-uftc8inx 8560 7 help help VB cord-010092-uftc8inx 8560 8 reproductive reproductive JJ cord-010092-uftc8inx 8560 9 success success NN cord-010092-uftc8inx 8560 10 by by IN cord-010092-uftc8inx 8560 11 blocking block VBG cord-010092-uftc8inx 8560 12 cervical cervical JJ cord-010092-uftc8inx 8560 13 ABO ABO NNP cord-010092-uftc8inx 8560 14 antibodies antibody NNS cord-010092-uftc8inx 8560 15 . . . cord-010092-uftc8inx 8561 1 Furthermore furthermore RB cord-010092-uftc8inx 8561 2 , , , cord-010092-uftc8inx 8561 3 if if IN cord-010092-uftc8inx 8561 4 the the DT cord-010092-uftc8inx 8561 5 male male NN cord-010092-uftc8inx 8561 6 is be VBZ cord-010092-uftc8inx 8561 7 heterozygous heterozygous JJ cord-010092-uftc8inx 8561 8 , , , cord-010092-uftc8inx 8561 9 cervical cervical JJ cord-010092-uftc8inx 8561 10 mucus mucus NN cord-010092-uftc8inx 8561 11 antibodies antibody NNS cord-010092-uftc8inx 8561 12 will will MD cord-010092-uftc8inx 8561 13 only only RB cord-010092-uftc8inx 8561 14 affect affect VB cord-010092-uftc8inx 8561 15 the the DT cord-010092-uftc8inx 8561 16 corresponding correspond VBG cord-010092-uftc8inx 8561 17 sperm sperm NN cord-010092-uftc8inx 8561 18 . . . cord-010092-uftc8inx 8562 1 We -PRON- PRP cord-010092-uftc8inx 8562 2 propose propose VBP cord-010092-uftc8inx 8562 3 to to TO cord-010092-uftc8inx 8562 4 evaluate evaluate VB cord-010092-uftc8inx 8562 5 ABH ABH NNP cord-010092-uftc8inx 8562 6 antigen antigen NN cord-010092-uftc8inx 8562 7 expression expression NN cord-010092-uftc8inx 8562 8 on on IN cord-010092-uftc8inx 8562 9 sperm sperm NN cord-010092-uftc8inx 8562 10 membrane membrane NN cord-010092-uftc8inx 8562 11 and and CC cord-010092-uftc8inx 8562 12 seminal seminal JJ cord-010092-uftc8inx 8562 13 plasma plasma NN cord-010092-uftc8inx 8562 14 as as RB cord-010092-uftc8inx 8562 15 well well RB cord-010092-uftc8inx 8562 16 as as IN cord-010092-uftc8inx 8562 17 ABO ABO NNP cord-010092-uftc8inx 8562 18 antibodies antibody NNS cord-010092-uftc8inx 8562 19 in in IN cord-010092-uftc8inx 8562 20 cervical cervical JJ cord-010092-uftc8inx 8562 21 mucus mucus NN cord-010092-uftc8inx 8562 22 to to TO cord-010092-uftc8inx 8562 23 contribute contribute VB cord-010092-uftc8inx 8562 24 to to IN cord-010092-uftc8inx 8562 25 the the DT cord-010092-uftc8inx 8562 26 diagnosis diagnosis NN cord-010092-uftc8inx 8562 27 and and CC cord-010092-uftc8inx 8562 28 treatment treatment NN cord-010092-uftc8inx 8562 29 of of IN cord-010092-uftc8inx 8562 30 human human JJ cord-010092-uftc8inx 8562 31 infertility infertility NN cord-010092-uftc8inx 8562 32 . . . cord-010092-uftc8inx 8563 1 Background background NN cord-010092-uftc8inx 8563 2 : : : cord-010092-uftc8inx 8564 1 The the DT cord-010092-uftc8inx 8564 2 H H NNP cord-010092-uftc8inx 8564 3 blood blood NN cord-010092-uftc8inx 8564 4 group group NN cord-010092-uftc8inx 8564 5 contains contain VBZ cord-010092-uftc8inx 8564 6 one one CD cord-010092-uftc8inx 8564 7 antigen antigen NN cord-010092-uftc8inx 8564 8 , , , cord-010092-uftc8inx 8564 9 the the DT cord-010092-uftc8inx 8564 10 H h NN cord-010092-uftc8inx 8564 11 antigen antigen NN cord-010092-uftc8inx 8564 12 , , , cord-010092-uftc8inx 8564 13 which which WDT cord-010092-uftc8inx 8564 14 is be VBZ cord-010092-uftc8inx 8564 15 present present JJ cord-010092-uftc8inx 8564 16 on on IN cord-010092-uftc8inx 8564 17 virtually virtually RB cord-010092-uftc8inx 8564 18 all all DT cord-010092-uftc8inx 8564 19 red red JJ cord-010092-uftc8inx 8564 20 blood blood NN cord-010092-uftc8inx 8564 21 cells cell NNS cord-010092-uftc8inx 8564 22 ( ( -LRB- cord-010092-uftc8inx 8564 23 RBC RBC NNP cord-010092-uftc8inx 8564 24 ) ) -RRB- cord-010092-uftc8inx 8564 25 and and CC cord-010092-uftc8inx 8564 26 is be VBZ cord-010092-uftc8inx 8564 27 the the DT cord-010092-uftc8inx 8564 28 acceptor acceptor NN cord-010092-uftc8inx 8564 29 substrate substrate NN cord-010092-uftc8inx 8564 30 of of IN cord-010092-uftc8inx 8564 31 both both CC cord-010092-uftc8inx 8564 32 A A NNP cord-010092-uftc8inx 8564 33 and and CC cord-010092-uftc8inx 8564 34 B b NN cord-010092-uftc8inx 8564 35 gene gene NN cord-010092-uftc8inx 8564 36 - - HYPH cord-010092-uftc8inx 8564 37 specified specify VBN cord-010092-uftc8inx 8564 38 glycosyltransferases glycosyltransferase NNS cord-010092-uftc8inx 8564 39 . . . cord-010092-uftc8inx 8565 1 In in IN cord-010092-uftc8inx 8565 2 blood blood NN cord-010092-uftc8inx 8565 3 group group NN cord-010092-uftc8inx 8565 4 O o NN cord-010092-uftc8inx 8566 1 the the DT cord-010092-uftc8inx 8566 2 H H NNP cord-010092-uftc8inx 8566 3 antigen antigen NN cord-010092-uftc8inx 8566 4 remains remain VBZ cord-010092-uftc8inx 8566 5 unmodified unmodified JJ cord-010092-uftc8inx 8566 6 and and CC cord-010092-uftc8inx 8566 7 therefore therefore RB cord-010092-uftc8inx 8566 8 its -PRON- PRP$ cord-010092-uftc8inx 8566 9 RBCs rbc NNS cord-010092-uftc8inx 8566 10 show show VBP cord-010092-uftc8inx 8566 11 the the DT cord-010092-uftc8inx 8566 12 highest high JJS cord-010092-uftc8inx 8566 13 and and CC cord-010092-uftc8inx 8566 14 the the DT cord-010092-uftc8inx 8566 15 RBCs rbc NNS cord-010092-uftc8inx 8566 16 of of IN cord-010092-uftc8inx 8566 17 blood blood NN cord-010092-uftc8inx 8566 18 type type NN cord-010092-uftc8inx 8566 19 AB AB NNP cord-010092-uftc8inx 8566 20 the the DT cord-010092-uftc8inx 8566 21 least least JJS cord-010092-uftc8inx 8566 22 amounts amount NNS cord-010092-uftc8inx 8566 23 of of IN cord-010092-uftc8inx 8566 24 H h NN cord-010092-uftc8inx 8566 25 antigen antigen NN cord-010092-uftc8inx 8566 26 . . . cord-010092-uftc8inx 8567 1 Individuals individual NNS cord-010092-uftc8inx 8567 2 with with IN cord-010092-uftc8inx 8567 3 the the DT cord-010092-uftc8inx 8567 4 so so RB cord-010092-uftc8inx 8567 5 called call VBN cord-010092-uftc8inx 8567 6 Bombay Bombay NNP cord-010092-uftc8inx 8567 7 phenotype phenotype NN cord-010092-uftc8inx 8567 8 carry carry VBP cord-010092-uftc8inx 8567 9 homozygous homozygous JJ cord-010092-uftc8inx 8567 10 H h NN cord-010092-uftc8inx 8567 11 null null NN cord-010092-uftc8inx 8567 12 alleles allele NNS cord-010092-uftc8inx 8567 13 ( ( -LRB- cord-010092-uftc8inx 8567 14 h h NN cord-010092-uftc8inx 8567 15 | | NNP cord-010092-uftc8inx 8567 16 h h NNP cord-010092-uftc8inx 8567 17 ) ) -RRB- cord-010092-uftc8inx 8567 18 and and CC cord-010092-uftc8inx 8567 19 do do VBP cord-010092-uftc8inx 8567 20 not not RB cord-010092-uftc8inx 8567 21 produce produce VB cord-010092-uftc8inx 8567 22 any any DT cord-010092-uftc8inx 8567 23 H h NN cord-010092-uftc8inx 8567 24 antigen antigen NN cord-010092-uftc8inx 8567 25 . . . cord-010092-uftc8inx 8568 1 The the DT cord-010092-uftc8inx 8568 2 para para NNP cord-010092-uftc8inx 8568 3 - - HYPH cord-010092-uftc8inx 8568 4 Bombay Bombay NNP cord-010092-uftc8inx 8568 5 phenotype phenotype NN cord-010092-uftc8inx 8568 6 retains retain VBZ cord-010092-uftc8inx 8568 7 some some DT cord-010092-uftc8inx 8568 8 H h NN cord-010092-uftc8inx 8568 9 antigen antigen NN cord-010092-uftc8inx 8568 10 on on IN cord-010092-uftc8inx 8568 11 RBCs rbc NNS cord-010092-uftc8inx 8568 12 either either CC cord-010092-uftc8inx 8568 13 induced induce VBN cord-010092-uftc8inx 8568 14 by by IN cord-010092-uftc8inx 8568 15 a a DT cord-010092-uftc8inx 8568 16 weakly weakly RB cord-010092-uftc8inx 8568 17 active active JJ cord-010092-uftc8inx 8568 18 ( ( -LRB- cord-010092-uftc8inx 8568 19 H+ H+ NNP cord-010092-uftc8inx 8568 20 w w NNP cord-010092-uftc8inx 8568 21 | | NNP cord-010092-uftc8inx 8568 22 H+ H+ NNP cord-010092-uftc8inx 8568 23 w w NNP cord-010092-uftc8inx 8568 24 ) ) -RRB- cord-010092-uftc8inx 8568 25 or or CC cord-010092-uftc8inx 8568 26 completely completely RB cord-010092-uftc8inx 8568 27 silenced silence VBN cord-010092-uftc8inx 8568 28 FUT1 FUT1 NNP cord-010092-uftc8inx 8568 29 gene gene NN cord-010092-uftc8inx 8568 30 ( ( -LRB- cord-010092-uftc8inx 8568 31 h h NNP cord-010092-uftc8inx 8568 32 | | NNP cord-010092-uftc8inx 8568 33 h h NNP cord-010092-uftc8inx 8568 34 ) ) -RRB- cord-010092-uftc8inx 8568 35 , , , cord-010092-uftc8inx 8568 36 mandatory mandatory JJ cord-010092-uftc8inx 8568 37 linked link VBN cord-010092-uftc8inx 8568 38 with with IN cord-010092-uftc8inx 8568 39 an an DT cord-010092-uftc8inx 8568 40 active active JJ cord-010092-uftc8inx 8568 41 FUT2 FUT2 NNP cord-010092-uftc8inx 8568 42 gene gene NN cord-010092-uftc8inx 8568 43 . . . cord-010092-uftc8inx 8569 1 Aims aim VBZ cord-010092-uftc8inx 8569 2 : : : cord-010092-uftc8inx 8570 1 In in IN cord-010092-uftc8inx 8570 2 this this DT cord-010092-uftc8inx 8570 3 study study NN cord-010092-uftc8inx 8570 4 , , , cord-010092-uftc8inx 8570 5 we -PRON- PRP cord-010092-uftc8inx 8570 6 aimed aim VBD cord-010092-uftc8inx 8570 7 to to TO cord-010092-uftc8inx 8570 8 develop develop VB cord-010092-uftc8inx 8570 9 an an DT cord-010092-uftc8inx 8570 10 adapted adapt VBN cord-010092-uftc8inx 8570 11 flow flow NN cord-010092-uftc8inx 8570 12 cytometric cytometric NN cord-010092-uftc8inx 8570 13 method method NN cord-010092-uftc8inx 8570 14 to to TO cord-010092-uftc8inx 8570 15 quantify quantify VB cord-010092-uftc8inx 8570 16 the the DT cord-010092-uftc8inx 8570 17 relative relative JJ cord-010092-uftc8inx 8570 18 amount amount NN cord-010092-uftc8inx 8570 19 of of IN cord-010092-uftc8inx 8570 20 H h NN cord-010092-uftc8inx 8570 21 substance substance NN cord-010092-uftc8inx 8570 22 present present JJ cord-010092-uftc8inx 8570 23 on on IN cord-010092-uftc8inx 8570 24 RBCs rbc NNS cord-010092-uftc8inx 8570 25 in in IN cord-010092-uftc8inx 8570 26 order order NN cord-010092-uftc8inx 8570 27 to to TO cord-010092-uftc8inx 8570 28 distinguish distinguish VB cord-010092-uftc8inx 8570 29 different different JJ cord-010092-uftc8inx 8570 30 ABO ABO NNP cord-010092-uftc8inx 8570 31 phenotypes phenotype NNS cord-010092-uftc8inx 8570 32 in in IN cord-010092-uftc8inx 8570 33 routine routine JJ cord-010092-uftc8inx 8570 34 diagnostics diagnostic NNS cord-010092-uftc8inx 8570 35 as as RB cord-010092-uftc8inx 8570 36 well well RB cord-010092-uftc8inx 8570 37 as as IN cord-010092-uftc8inx 8570 38 to to TO cord-010092-uftc8inx 8570 39 capture capture VB cord-010092-uftc8inx 8570 40 rare rare JJ cord-010092-uftc8inx 8570 41 H h NN cord-010092-uftc8inx 8570 42 - - HYPH cord-010092-uftc8inx 8570 43 deficient deficient JJ cord-010092-uftc8inx 8570 44 phenotypes phenotype NNS cord-010092-uftc8inx 8570 45 . . . cord-010092-uftc8inx 8571 1 Methods method NNS cord-010092-uftc8inx 8571 2 : : : cord-010092-uftc8inx 8572 1 Analyses analysis NNS cord-010092-uftc8inx 8572 2 were be VBD cord-010092-uftc8inx 8572 3 performed perform VBN cord-010092-uftc8inx 8572 4 on on IN cord-010092-uftc8inx 8572 5 a a DT cord-010092-uftc8inx 8572 6 flow flow NN cord-010092-uftc8inx 8572 7 cytometer cytometer NN cord-010092-uftc8inx 8572 8 ( ( -LRB- cord-010092-uftc8inx 8572 9 FACS FACS NNP cord-010092-uftc8inx 8572 10 Canto Canto NNP cord-010092-uftc8inx 8572 11 II II NNP cord-010092-uftc8inx 8572 12 , , , cord-010092-uftc8inx 8572 13 BD BD NNP cord-010092-uftc8inx 8572 14 Biosciences Biosciences NNP cord-010092-uftc8inx 8572 15 , , , cord-010092-uftc8inx 8572 16 CH CH NNP cord-010092-uftc8inx 8572 17 ) ) -RRB- cord-010092-uftc8inx 8572 18 and and CC cord-010092-uftc8inx 8572 19 measured measure VBN cord-010092-uftc8inx 8572 20 with with IN cord-010092-uftc8inx 8572 21 identical identical JJ cord-010092-uftc8inx 8572 22 instrument instrument NN cord-010092-uftc8inx 8572 23 settings setting NNS cord-010092-uftc8inx 8572 24 . . . cord-010092-uftc8inx 8573 1 List list NN cord-010092-uftc8inx 8573 2 mode mode NN cord-010092-uftc8inx 8573 3 data datum NNS cord-010092-uftc8inx 8573 4 were be VBD cord-010092-uftc8inx 8573 5 evaluated evaluate VBN cord-010092-uftc8inx 8573 6 and and CC cord-010092-uftc8inx 8573 7 visualised visualise VBN cord-010092-uftc8inx 8573 8 using use VBG cord-010092-uftc8inx 8573 9 BD BD NNP cord-010092-uftc8inx 8573 10 FACSDiva facsdiva NN cord-010092-uftc8inx 8573 11 software software NN cord-010092-uftc8inx 8573 12 . . . cord-010092-uftc8inx 8574 1 RBCs rbc NNS cord-010092-uftc8inx 8574 2 were be VBD cord-010092-uftc8inx 8574 3 incubated incubate VBN cord-010092-uftc8inx 8574 4 with with IN cord-010092-uftc8inx 8574 5 increasing increase VBG cord-010092-uftc8inx 8574 6 concentrations concentration NNS cord-010092-uftc8inx 8574 7 of of IN cord-010092-uftc8inx 8574 8 monoclonal monoclonal JJ cord-010092-uftc8inx 8574 9 anti anti JJ cord-010092-uftc8inx 8574 10 - - JJ cord-010092-uftc8inx 8574 11 H h JJ cord-010092-uftc8inx 8574 12 antibodies antibody NNS cord-010092-uftc8inx 8574 13 ( ( -LRB- cord-010092-uftc8inx 8574 14 BRIC231-PE bric231-pe CD cord-010092-uftc8inx 8574 15 and and CC cord-010092-uftc8inx 8574 16 a a DT cord-010092-uftc8inx 8574 17 1:1 1:1 CD cord-010092-uftc8inx 8574 18 mixture mixture NN cord-010092-uftc8inx 8574 19 of of IN cord-010092-uftc8inx 8574 20 BRIC231-PE bric231-pe CD cord-010092-uftc8inx 8574 21 / / SYM cord-010092-uftc8inx 8574 22 BRIC231 BRIC231 NNP cord-010092-uftc8inx 8574 23 , , , cord-010092-uftc8inx 8574 24 IBGRL IBGRL NNP cord-010092-uftc8inx 8574 25 , , , cord-010092-uftc8inx 8574 26 UK UK NNP cord-010092-uftc8inx 8574 27 ) ) -RRB- cord-010092-uftc8inx 8574 28 . . . cord-010092-uftc8inx 8575 1 After after IN cord-010092-uftc8inx 8575 2 rinsing rinse VBG cord-010092-uftc8inx 8575 3 the the DT cord-010092-uftc8inx 8575 4 cells cell NNS cord-010092-uftc8inx 8575 5 with with IN cord-010092-uftc8inx 8575 6 PBS PBS NNP cord-010092-uftc8inx 8575 7 , , , cord-010092-uftc8inx 8575 8 micro micro NNS cord-010092-uftc8inx 8575 9 - - NNS cord-010092-uftc8inx 8575 10 aggregates aggregate NNS cord-010092-uftc8inx 8575 11 were be VBD cord-010092-uftc8inx 8575 12 mechanically mechanically RB cord-010092-uftc8inx 8575 13 dissolved dissolve VBN cord-010092-uftc8inx 8575 14 . . . cord-010092-uftc8inx 8576 1 RBCs rbc NNS cord-010092-uftc8inx 8576 2 from from IN cord-010092-uftc8inx 8576 3 29 29 CD cord-010092-uftc8inx 8576 4 blood blood NN cord-010092-uftc8inx 8576 5 donors donor NNS cord-010092-uftc8inx 8576 6 with with IN cord-010092-uftc8inx 8576 7 different different JJ cord-010092-uftc8inx 8576 8 ABO ABO NNP cord-010092-uftc8inx 8576 9 phenotypes phenotype NNS cord-010092-uftc8inx 8576 10 ( ( -LRB- cord-010092-uftc8inx 8576 11 O o UH cord-010092-uftc8inx 8576 12 ( ( -LRB- cord-010092-uftc8inx 8576 13 5 5 CD cord-010092-uftc8inx 8576 14 ) ) -RRB- cord-010092-uftc8inx 8576 15 , , , cord-010092-uftc8inx 8576 16 A a DT cord-010092-uftc8inx 8576 17 1 1 CD cord-010092-uftc8inx 8576 18 ( ( -LRB- cord-010092-uftc8inx 8576 19 5 5 CD cord-010092-uftc8inx 8576 20 ) ) -RRB- cord-010092-uftc8inx 8576 21 , , , cord-010092-uftc8inx 8576 22 A a DT cord-010092-uftc8inx 8576 23 2 2 CD cord-010092-uftc8inx 8576 24 ( ( -LRB- cord-010092-uftc8inx 8576 25 5 5 CD cord-010092-uftc8inx 8576 26 ) ) -RRB- cord-010092-uftc8inx 8576 27 , , , cord-010092-uftc8inx 8576 28 B B NNP cord-010092-uftc8inx 8576 29 ( ( -LRB- cord-010092-uftc8inx 8576 30 5 5 CD cord-010092-uftc8inx 8576 31 ) ) -RRB- cord-010092-uftc8inx 8576 32 , , , cord-010092-uftc8inx 8576 33 A a DT cord-010092-uftc8inx 8576 34 1 1 CD cord-010092-uftc8inx 8576 35 B b NN cord-010092-uftc8inx 8576 36 ( ( -LRB- cord-010092-uftc8inx 8576 37 5 5 CD cord-010092-uftc8inx 8576 38 ) ) -RRB- cord-010092-uftc8inx 8576 39 , , , cord-010092-uftc8inx 8576 40 A a DT cord-010092-uftc8inx 8576 41 2 2 CD cord-010092-uftc8inx 8576 42 B b NN cord-010092-uftc8inx 8576 43 ( ( -LRB- cord-010092-uftc8inx 8576 44 4 4 CD cord-010092-uftc8inx 8576 45 ) ) -RRB- cord-010092-uftc8inx 8576 46 ) ) -RRB- cord-010092-uftc8inx 8576 47 and and CC cord-010092-uftc8inx 8576 48 2 2 CD cord-010092-uftc8inx 8576 49 patients patient NNS cord-010092-uftc8inx 8576 50 with with IN cord-010092-uftc8inx 8576 51 genetically genetically RB cord-010092-uftc8inx 8576 52 confirmed confirm VBN cord-010092-uftc8inx 8576 53 Bombay Bombay NNP cord-010092-uftc8inx 8576 54 and and CC cord-010092-uftc8inx 8576 55 Para Para NNP cord-010092-uftc8inx 8576 56 - - HYPH cord-010092-uftc8inx 8576 57 Bombay Bombay NNP cord-010092-uftc8inx 8576 58 phenotype phenotype NN cord-010092-uftc8inx 8576 59 were be VBD cord-010092-uftc8inx 8576 60 assessed assess VBN cord-010092-uftc8inx 8576 61 . . . cord-010092-uftc8inx 8577 1 Results result NNS cord-010092-uftc8inx 8577 2 : : : cord-010092-uftc8inx 8578 1 Saturation saturation NN cord-010092-uftc8inx 8578 2 of of IN cord-010092-uftc8inx 8578 3 H h NN cord-010092-uftc8inx 8578 4 antigen antigen NN cord-010092-uftc8inx 8578 5 binding bind VBG cord-010092-uftc8inx 8578 6 sites site NNS cord-010092-uftc8inx 8578 7 on on IN cord-010092-uftc8inx 8578 8 type type NN cord-010092-uftc8inx 8578 9 O o NN cord-010092-uftc8inx 8578 10 RBCs rbc NNS cord-010092-uftc8inx 8578 11 was be VBD cord-010092-uftc8inx 8578 12 achieved achieve VBN cord-010092-uftc8inx 8578 13 only only RB cord-010092-uftc8inx 8578 14 upon upon IN cord-010092-uftc8inx 8578 15 use use NN cord-010092-uftc8inx 8578 16 of of IN cord-010092-uftc8inx 8578 17 a a DT cord-010092-uftc8inx 8578 18 1:1 1:1 CD cord-010092-uftc8inx 8578 19 antibody antibody NN cord-010092-uftc8inx 8578 20 mixture mixture NN cord-010092-uftc8inx 8578 21 ( ( -LRB- cord-010092-uftc8inx 8578 22 BRIC231-PE BRIC231-PE NNP cord-010092-uftc8inx 8578 23 / / SYM cord-010092-uftc8inx 8578 24 BRIC231 BRIC231 NNP cord-010092-uftc8inx 8578 25 ) ) -RRB- cord-010092-uftc8inx 8578 26 covering cover VBG cord-010092-uftc8inx 8578 27 approx approx NN cord-010092-uftc8inx 8578 28 . . . cord-010092-uftc8inx 8579 1 half half NN cord-010092-uftc8inx 8579 2 of of IN cord-010092-uftc8inx 8579 3 the the DT cord-010092-uftc8inx 8579 4 H h NN cord-010092-uftc8inx 8579 5 - - HYPH cord-010092-uftc8inx 8579 6 binding bind VBG cord-010092-uftc8inx 8579 7 sites site NNS cord-010092-uftc8inx 8579 8 by by IN cord-010092-uftc8inx 8579 9 unconjugated unconjugated JJ cord-010092-uftc8inx 8579 10 BRIC231 BRIC231 NNP cord-010092-uftc8inx 8579 11 . . . cord-010092-uftc8inx 8580 1 In in IN cord-010092-uftc8inx 8580 2 contrast contrast NN cord-010092-uftc8inx 8580 3 , , , cord-010092-uftc8inx 8580 4 Non Non NNP cord-010092-uftc8inx 8580 5 - - HYPH cord-010092-uftc8inx 8580 6 O o NN cord-010092-uftc8inx 8580 7 type type NN cord-010092-uftc8inx 8580 8 RBCs rbc NNS cord-010092-uftc8inx 8580 9 reached reach VBD cord-010092-uftc8inx 8580 10 saturation saturation NN cord-010092-uftc8inx 8580 11 of of IN cord-010092-uftc8inx 8580 12 H h NN cord-010092-uftc8inx 8580 13 - - HYPH cord-010092-uftc8inx 8580 14 binding bind VBG cord-010092-uftc8inx 8580 15 sites site NNS cord-010092-uftc8inx 8580 16 using use VBG cord-010092-uftc8inx 8580 17 pure pure JJ cord-010092-uftc8inx 8580 18 BRIC231-PE bric231-pe CD cord-010092-uftc8inx 8580 19 . . . cord-010092-uftc8inx 8581 1 RBCs rbc NNS cord-010092-uftc8inx 8581 2 coated coat VBN cord-010092-uftc8inx 8581 3 with with IN cord-010092-uftc8inx 8581 4 BRIC231-PE bric231-pe CD cord-010092-uftc8inx 8581 5 at at IN cord-010092-uftc8inx 8581 6 saturation saturation NN cord-010092-uftc8inx 8581 7 revealed reveal VBD cord-010092-uftc8inx 8581 8 a a DT cord-010092-uftc8inx 8581 9 distinct distinct JJ cord-010092-uftc8inx 8581 10 pattern pattern NN cord-010092-uftc8inx 8581 11 of of IN cord-010092-uftc8inx 8581 12 MFI MFI NNP cord-010092-uftc8inx 8581 13 ( ( -LRB- cord-010092-uftc8inx 8581 14 mean mean VB cord-010092-uftc8inx 8581 15 fluorescence fluorescence NN cord-010092-uftc8inx 8581 16 intensity intensity NN cord-010092-uftc8inx 8581 17 ) ) -RRB- cord-010092-uftc8inx 8581 18 depending depend VBG cord-010092-uftc8inx 8581 19 on on IN cord-010092-uftc8inx 8581 20 the the DT cord-010092-uftc8inx 8581 21 ABO ABO NNP cord-010092-uftc8inx 8581 22 phenotype phenotype NN cord-010092-uftc8inx 8581 23 . . . cord-010092-uftc8inx 8582 1 In in IN cord-010092-uftc8inx 8582 2 addition addition NN cord-010092-uftc8inx 8582 3 , , , cord-010092-uftc8inx 8582 4 MFIs mfi NNS cord-010092-uftc8inx 8582 5 of of IN cord-010092-uftc8inx 8582 6 RBCs rbc NNS cord-010092-uftc8inx 8582 7 upon upon IN cord-010092-uftc8inx 8582 8 staining stain VBG cord-010092-uftc8inx 8582 9 with with IN cord-010092-uftc8inx 8582 10 BRIC231-PE BRIC231-PE NNP cord-010092-uftc8inx 8582 11 did do VBD cord-010092-uftc8inx 8582 12 discriminate discriminate VB cord-010092-uftc8inx 8582 13 Bombay Bombay NNP cord-010092-uftc8inx 8582 14 - - , cord-010092-uftc8inx 8582 15 and and CC cord-010092-uftc8inx 8582 16 Para Para NNP cord-010092-uftc8inx 8582 17 - - HYPH cord-010092-uftc8inx 8582 18 Bombay Bombay NNP cord-010092-uftc8inx 8582 19 type type NN cord-010092-uftc8inx 8582 20 RBCs rbc NNS cord-010092-uftc8inx 8582 21 , , , cord-010092-uftc8inx 8582 22 respectively respectively RB cord-010092-uftc8inx 8582 23 . . . cord-010092-uftc8inx 8583 1 Summary Summary NNP cord-010092-uftc8inx 8583 2 / / SYM cord-010092-uftc8inx 8583 3 Conclusions conclusion NNS cord-010092-uftc8inx 8583 4 : : : cord-010092-uftc8inx 8583 5 Adapted adapt VBN cord-010092-uftc8inx 8583 6 flow flow NN cord-010092-uftc8inx 8583 7 cytometry cytometry NN cord-010092-uftc8inx 8583 8 is be VBZ cord-010092-uftc8inx 8583 9 able able JJ cord-010092-uftc8inx 8583 10 to to TO cord-010092-uftc8inx 8583 11 distinguish distinguish VB cord-010092-uftc8inx 8583 12 variant variant JJ cord-010092-uftc8inx 8583 13 expressions expression NNS cord-010092-uftc8inx 8583 14 of of IN cord-010092-uftc8inx 8583 15 RBCs rbc NNS cord-010092-uftc8inx 8583 16 H H NNP cord-010092-uftc8inx 8583 17 antigen antigen NN cord-010092-uftc8inx 8583 18 . . . cord-010092-uftc8inx 8584 1 Thus thus RB cord-010092-uftc8inx 8584 2 , , , cord-010092-uftc8inx 8584 3 our -PRON- PRP$ cord-010092-uftc8inx 8584 4 flow flow NN cord-010092-uftc8inx 8584 5 cytometric cytometric NN cord-010092-uftc8inx 8584 6 method method NN cord-010092-uftc8inx 8584 7 may may MD cord-010092-uftc8inx 8584 8 complement complement VB cord-010092-uftc8inx 8584 9 traditional traditional JJ cord-010092-uftc8inx 8584 10 serological serological JJ cord-010092-uftc8inx 8584 11 and and CC cord-010092-uftc8inx 8584 12 genetic genetic JJ cord-010092-uftc8inx 8584 13 analyses analysis NNS cord-010092-uftc8inx 8584 14 in in IN cord-010092-uftc8inx 8584 15 routine routine JJ cord-010092-uftc8inx 8584 16 ABO ABO NNP cord-010092-uftc8inx 8584 17 phenotype phenotype NN cord-010092-uftc8inx 8584 18 cases case NNS cord-010092-uftc8inx 8584 19 or or CC cord-010092-uftc8inx 8584 20 , , , cord-010092-uftc8inx 8584 21 more more RBR cord-010092-uftc8inx 8584 22 intriguing intriguing JJ cord-010092-uftc8inx 8584 23 , , , cord-010092-uftc8inx 8584 24 when when WRB cord-010092-uftc8inx 8584 25 the the DT cord-010092-uftc8inx 8584 26 Bombay Bombay NNP cord-010092-uftc8inx 8584 27 or or CC cord-010092-uftc8inx 8584 28 para para NNP cord-010092-uftc8inx 8584 29 - - HYPH cord-010092-uftc8inx 8584 30 Bombay Bombay NNP cord-010092-uftc8inx 8584 31 phenotype phenotype NN cord-010092-uftc8inx 8584 32 is be VBZ cord-010092-uftc8inx 8584 33 suspected suspect VBN cord-010092-uftc8inx 8584 34 . . . cord-010092-uftc8inx 8585 1 It -PRON- PRP cord-010092-uftc8inx 8585 2 will will MD cord-010092-uftc8inx 8585 3 be be VB cord-010092-uftc8inx 8585 4 of of IN cord-010092-uftc8inx 8585 5 interest interest NN cord-010092-uftc8inx 8585 6 to to TO cord-010092-uftc8inx 8585 7 further further RB cord-010092-uftc8inx 8585 8 prove prove VB cord-010092-uftc8inx 8585 9 this this DT cord-010092-uftc8inx 8585 10 method method NN cord-010092-uftc8inx 8585 11 by by IN cord-010092-uftc8inx 8585 12 investigating investigate VBG cord-010092-uftc8inx 8585 13 additional additional JJ cord-010092-uftc8inx 8585 14 rare rare JJ cord-010092-uftc8inx 8585 15 H h NN cord-010092-uftc8inx 8585 16 - - HYPH cord-010092-uftc8inx 8585 17 deficient deficient JJ cord-010092-uftc8inx 8585 18 phenotype phenotype NN cord-010092-uftc8inx 8585 19 cases case NNS cord-010092-uftc8inx 8585 20 . . . cord-010092-uftc8inx 8586 1 S S NNP cord-010092-uftc8inx 8586 2 Chen Chen NNP cord-010092-uftc8inx 8586 3 1,2 1,2 CD cord-010092-uftc8inx 8586 4 , , , cord-010092-uftc8inx 8586 5 X X NNP cord-010092-uftc8inx 8586 6 Xu Xu NNP cord-010092-uftc8inx 8586 7 1,2 1,2 CD cord-010092-uftc8inx 8586 8 , , , cord-010092-uftc8inx 8586 9 X X NNP cord-010092-uftc8inx 8586 10 Hong Hong NNP cord-010092-uftc8inx 8586 11 1,2 1,2 CD cord-010092-uftc8inx 8587 1 , , , cord-010092-uftc8inx 8587 2 K K NNP cord-010092-uftc8inx 8587 3 Ma Ma NNP cord-010092-uftc8inx 8587 4 1,2 1,2 CD cord-010092-uftc8inx 8587 5 , , , cord-010092-uftc8inx 8587 6 J J NNP cord-010092-uftc8inx 8587 7 He He NNP cord-010092-uftc8inx 8587 8 1,2 1,2 CD cord-010092-uftc8inx 8587 9 , , , cord-010092-uftc8inx 8587 10 J J NNP cord-010092-uftc8inx 8587 11 Chen Chen NNP cord-010092-uftc8inx 8587 12 1,2 1,2 CD cord-010092-uftc8inx 8587 13 and and CC cord-010092-uftc8inx 8587 14 F F NNP cord-010092-uftc8inx 8587 15 Zhu Zhu NNP cord-010092-uftc8inx 8588 1 1,2 1,2 CD cord-010092-uftc8inx 8588 2 1 1 CD cord-010092-uftc8inx 8588 3 Blood blood NN cord-010092-uftc8inx 8588 4 centre centre NN cord-010092-uftc8inx 8588 5 of of IN cord-010092-uftc8inx 8588 6 Zhejiang Zhejiang NNP cord-010092-uftc8inx 8588 7 province province NN cord-010092-uftc8inx 8588 8 2 2 CD cord-010092-uftc8inx 8588 9 Zhejiang Zhejiang NNP cord-010092-uftc8inx 8588 10 provincial provincial JJ cord-010092-uftc8inx 8588 11 Key Key NNP cord-010092-uftc8inx 8588 12 Laboratory Laboratory NNP cord-010092-uftc8inx 8588 13 of of IN cord-010092-uftc8inx 8588 14 Blood Blood NNP cord-010092-uftc8inx 8588 15 Safety Safety NNP cord-010092-uftc8inx 8588 16 Research Research NNP cord-010092-uftc8inx 8588 17 , , , cord-010092-uftc8inx 8588 18 Hangzhou Hangzhou NNP cord-010092-uftc8inx 8588 19 , , , cord-010092-uftc8inx 8589 1 China China NNP cord-010092-uftc8inx 8589 2 Background Background NNP cord-010092-uftc8inx 8589 3 : : : cord-010092-uftc8inx 8589 4 Weakened weaken VBN cord-010092-uftc8inx 8589 5 A a NN cord-010092-uftc8inx 8589 6 and and CC cord-010092-uftc8inx 8589 7 B b NN cord-010092-uftc8inx 8589 8 antigen antigen NN cord-010092-uftc8inx 8589 9 expression expression NN cord-010092-uftc8inx 8589 10 results result NNS cord-010092-uftc8inx 8589 11 in in IN cord-010092-uftc8inx 8589 12 ABO ABO NNP cord-010092-uftc8inx 8589 13 typing type VBG cord-010092-uftc8inx 8589 14 discrepancies discrepancy NNS cord-010092-uftc8inx 8589 15 . . . cord-010092-uftc8inx 8590 1 H h NN cord-010092-uftc8inx 8590 2 gene gene NN cord-010092-uftc8inx 8590 3 controls control VBZ cord-010092-uftc8inx 8590 4 the the DT cord-010092-uftc8inx 8590 5 development development NN cord-010092-uftc8inx 8590 6 of of IN cord-010092-uftc8inx 8590 7 H h NN cord-010092-uftc8inx 8590 8 substance substance NN cord-010092-uftc8inx 8590 9 from from IN cord-010092-uftc8inx 8590 10 which which WDT cord-010092-uftc8inx 8590 11 A a NN cord-010092-uftc8inx 8590 12 and and CC cord-010092-uftc8inx 8590 13 B b NN cord-010092-uftc8inx 8590 14 antigens antigen NNS cord-010092-uftc8inx 8590 15 develop develop VB cord-010092-uftc8inx 8590 16 . . . cord-010092-uftc8inx 8591 1 Depressed depressed JJ cord-010092-uftc8inx 8591 2 A A NNP cord-010092-uftc8inx 8591 3 and and CC cord-010092-uftc8inx 8591 4 B b NN cord-010092-uftc8inx 8591 5 antigen antigen NN cord-010092-uftc8inx 8591 6 expression expression NN cord-010092-uftc8inx 8591 7 and and CC cord-010092-uftc8inx 8591 8 strengthened strengthen VBD cord-010092-uftc8inx 8591 9 H h NN cord-010092-uftc8inx 8591 10 antigen antigen NN cord-010092-uftc8inx 8591 11 expression expression NN cord-010092-uftc8inx 8591 12 are be VBP cord-010092-uftc8inx 8591 13 always always RB cord-010092-uftc8inx 8591 14 simultaneously simultaneously RB cord-010092-uftc8inx 8591 15 observed observe VBN cord-010092-uftc8inx 8591 16 in in IN cord-010092-uftc8inx 8591 17 ABO ABO NNP cord-010092-uftc8inx 8591 18 subgroups subgroup NNS cord-010092-uftc8inx 8591 19 . . . cord-010092-uftc8inx 8592 1 There there EX cord-010092-uftc8inx 8592 2 are be VBP cord-010092-uftc8inx 8592 3 other other JJ cord-010092-uftc8inx 8592 4 possibilities possibility NNS cord-010092-uftc8inx 8592 5 for for IN cord-010092-uftc8inx 8592 6 weak weak JJ cord-010092-uftc8inx 8592 7 antigen antigen NN cord-010092-uftc8inx 8592 8 expression expression NN cord-010092-uftc8inx 8592 9 of of IN cord-010092-uftc8inx 8592 10 ABO ABO NNP cord-010092-uftc8inx 8592 11 system system NN cord-010092-uftc8inx 8592 12 such such JJ cord-010092-uftc8inx 8592 13 as as IN cord-010092-uftc8inx 8592 14 leukemic leukemic JJ cord-010092-uftc8inx 8592 15 change change NN cord-010092-uftc8inx 8592 16 and and CC cord-010092-uftc8inx 8592 17 pregnancy pregnancy NN cord-010092-uftc8inx 8592 18 . . . cord-010092-uftc8inx 8593 1 It -PRON- PRP cord-010092-uftc8inx 8593 2 is be VBZ cord-010092-uftc8inx 8593 3 undiscovered undiscovered JJ cord-010092-uftc8inx 8593 4 whether whether IN cord-010092-uftc8inx 8593 5 abnormal abnormal JJ cord-010092-uftc8inx 8593 6 expressions expression NNS cord-010092-uftc8inx 8593 7 of of IN cord-010092-uftc8inx 8593 8 A a NN cord-010092-uftc8inx 8593 9 , , , cord-010092-uftc8inx 8593 10 B b NN cord-010092-uftc8inx 8593 11 and and CC cord-010092-uftc8inx 8593 12 H h NN cord-010092-uftc8inx 8593 13 antigen antigen NN cord-010092-uftc8inx 8593 14 stand stand NN cord-010092-uftc8inx 8593 15 for for IN cord-010092-uftc8inx 8593 16 ABO ABO NNP cord-010092-uftc8inx 8593 17 subgroups subgroup NNS cord-010092-uftc8inx 8593 18 in in IN cord-010092-uftc8inx 8593 19 hemopathic hemopathic JJ cord-010092-uftc8inx 8593 20 patients patient NNS cord-010092-uftc8inx 8593 21 . . . cord-010092-uftc8inx 8594 1 Aims aim VBZ cord-010092-uftc8inx 8594 2 : : : cord-010092-uftc8inx 8595 1 The the DT cord-010092-uftc8inx 8595 2 aim aim NN cord-010092-uftc8inx 8595 3 of of IN cord-010092-uftc8inx 8595 4 this this DT cord-010092-uftc8inx 8595 5 study study NN cord-010092-uftc8inx 8595 6 is be VBZ cord-010092-uftc8inx 8595 7 to to TO cord-010092-uftc8inx 8595 8 explore explore VB cord-010092-uftc8inx 8595 9 the the DT cord-010092-uftc8inx 8595 10 role role NN cord-010092-uftc8inx 8595 11 of of IN cord-010092-uftc8inx 8595 12 enhanced enhanced JJ cord-010092-uftc8inx 8595 13 reactions reaction NNS cord-010092-uftc8inx 8595 14 with with IN cord-010092-uftc8inx 8595 15 anti anti JJ cord-010092-uftc8inx 8595 16 - - JJ cord-010092-uftc8inx 8595 17 H h NN cord-010092-uftc8inx 8595 18 in in IN cord-010092-uftc8inx 8595 19 direction direction NN cord-010092-uftc8inx 8595 20 to to IN cord-010092-uftc8inx 8595 21 ABO ABO NNP cord-010092-uftc8inx 8595 22 subgroups subgroup NNS cord-010092-uftc8inx 8595 23 of of IN cord-010092-uftc8inx 8595 24 hemopathic hemopathic JJ cord-010092-uftc8inx 8595 25 patients patient NNS cord-010092-uftc8inx 8595 26 . . . cord-010092-uftc8inx 8596 1 Methods method NNS cord-010092-uftc8inx 8596 2 : : : cord-010092-uftc8inx 8596 3 109 109 CD cord-010092-uftc8inx 8596 4 samples sample NNS cord-010092-uftc8inx 8596 5 from from IN cord-010092-uftc8inx 8596 6 blood blood NN cord-010092-uftc8inx 8596 7 donors donor NNS cord-010092-uftc8inx 8596 8 and and CC cord-010092-uftc8inx 8596 9 hemopathic hemopathic JJ cord-010092-uftc8inx 8596 10 patients patient NNS cord-010092-uftc8inx 8596 11 with with IN cord-010092-uftc8inx 8596 12 nonconcordant nonconcordant JJ cord-010092-uftc8inx 8596 13 ABO ABO NNP cord-010092-uftc8inx 8596 14 typing type VBG cord-010092-uftc8inx 8596 15 by by IN cord-010092-uftc8inx 8596 16 serological serological JJ cord-010092-uftc8inx 8596 17 tests test NNS cord-010092-uftc8inx 8596 18 were be VBD cord-010092-uftc8inx 8596 19 collected collect VBN cord-010092-uftc8inx 8596 20 after after IN cord-010092-uftc8inx 8596 21 consent consent NN cord-010092-uftc8inx 8596 22 information information NN cord-010092-uftc8inx 8596 23 . . . cord-010092-uftc8inx 8597 1 The the DT cord-010092-uftc8inx 8597 2 agglutination agglutination NN cord-010092-uftc8inx 8597 3 strength strength NN cord-010092-uftc8inx 8597 4 of of IN cord-010092-uftc8inx 8597 5 these these DT cord-010092-uftc8inx 8597 6 RBCs rbc NNS cord-010092-uftc8inx 8597 7 with with IN cord-010092-uftc8inx 8597 8 anti anti JJ cord-010092-uftc8inx 8597 9 - - JJ cord-010092-uftc8inx 8597 10 H h NN cord-010092-uftc8inx 8597 11 reagent reagent NN cord-010092-uftc8inx 8597 12 was be VBD cord-010092-uftc8inx 8597 13 recorded record VBN cord-010092-uftc8inx 8597 14 . . . cord-010092-uftc8inx 8598 1 Enhanced enhanced JJ cord-010092-uftc8inx 8598 2 reactions reaction NNS cord-010092-uftc8inx 8598 3 were be VBD cord-010092-uftc8inx 8598 4 determined determine VBN cord-010092-uftc8inx 8598 5 by by IN cord-010092-uftc8inx 8598 6 comparison comparison NN cord-010092-uftc8inx 8598 7 with with IN cord-010092-uftc8inx 8598 8 the the DT cord-010092-uftc8inx 8598 9 results result NNS cord-010092-uftc8inx 8598 10 from from IN cord-010092-uftc8inx 8598 11 normal normal JJ cord-010092-uftc8inx 8598 12 ABO ABO NNP cord-010092-uftc8inx 8598 13 groups group NNS cord-010092-uftc8inx 8598 14 . . . cord-010092-uftc8inx 8599 1 The the DT cord-010092-uftc8inx 8599 2 genomic genomic JJ cord-010092-uftc8inx 8599 3 DNAs dna NNS cord-010092-uftc8inx 8599 4 of of IN cord-010092-uftc8inx 8599 5 109 109 CD cord-010092-uftc8inx 8599 6 samples sample NNS cord-010092-uftc8inx 8599 7 were be VBD cord-010092-uftc8inx 8599 8 extracted extract VBN cord-010092-uftc8inx 8599 9 and and CC cord-010092-uftc8inx 8599 10 genotyped genotype VBN cord-010092-uftc8inx 8599 11 for for IN cord-010092-uftc8inx 8599 12 ABO ABO NNP cord-010092-uftc8inx 8599 13 system system NN cord-010092-uftc8inx 8599 14 . . . cord-010092-uftc8inx 8600 1 This this DT cord-010092-uftc8inx 8600 2 work work NN cord-010092-uftc8inx 8600 3 was be VBD cord-010092-uftc8inx 8600 4 sponsored sponsor VBN cord-010092-uftc8inx 8600 5 by by IN cord-010092-uftc8inx 8600 6 the the DT cord-010092-uftc8inx 8600 7 Medical Medical NNP cord-010092-uftc8inx 8600 8 Science Science NNP cord-010092-uftc8inx 8600 9 Research Research NNP cord-010092-uftc8inx 8600 10 Foundation Foundation NNP cord-010092-uftc8inx 8600 11 of of IN cord-010092-uftc8inx 8600 12 Zhejiang Zhejiang NNP cord-010092-uftc8inx 8600 13 Province Province NNP cord-010092-uftc8inx 8600 14 ( ( -LRB- cord-010092-uftc8inx 8600 15 2018RC029 2018RC029 NNP cord-010092-uftc8inx 8600 16 ) ) -RRB- cord-010092-uftc8inx 8600 17 . . . cord-010092-uftc8inx 8601 1 Results result NNS cord-010092-uftc8inx 8601 2 : : : cord-010092-uftc8inx 8602 1 69 69 CD cord-010092-uftc8inx 8602 2 samples sample NNS cord-010092-uftc8inx 8602 3 in in IN cord-010092-uftc8inx 8602 4 80 80 CD cord-010092-uftc8inx 8602 5 blood blood NN cord-010092-uftc8inx 8602 6 donors donor NNS cord-010092-uftc8inx 8602 7 showed show VBD cord-010092-uftc8inx 8602 8 increased increased JJ cord-010092-uftc8inx 8602 9 expression expression NN cord-010092-uftc8inx 8602 10 of of IN cord-010092-uftc8inx 8602 11 H h NN cord-010092-uftc8inx 8602 12 antigen antigen NN cord-010092-uftc8inx 8602 13 , , , cord-010092-uftc8inx 8602 14 of of IN cord-010092-uftc8inx 8602 15 which which WDT cord-010092-uftc8inx 8602 16 47 47 CD cord-010092-uftc8inx 8602 17 were be VBD cord-010092-uftc8inx 8602 18 identified identify VBN cord-010092-uftc8inx 8602 19 as as IN cord-010092-uftc8inx 8602 20 ABO ABO NNP cord-010092-uftc8inx 8602 21 subgroups subgroup NNS cord-010092-uftc8inx 8602 22 . . . cord-010092-uftc8inx 8603 1 There there EX cord-010092-uftc8inx 8603 2 were be VBD cord-010092-uftc8inx 8603 3 22 22 CD cord-010092-uftc8inx 8603 4 enhanced enhance VBN cord-010092-uftc8inx 8603 5 reactions reaction NNS cord-010092-uftc8inx 8603 6 in in IN cord-010092-uftc8inx 8603 7 29 29 CD cord-010092-uftc8inx 8603 8 hemopathic hemopathic JJ cord-010092-uftc8inx 8603 9 patients patient NNS cord-010092-uftc8inx 8603 10 . . . cord-010092-uftc8inx 8604 1 However however RB cord-010092-uftc8inx 8604 2 , , , cord-010092-uftc8inx 8604 3 19 19 CD cord-010092-uftc8inx 8604 4 were be VBD cord-010092-uftc8inx 8604 5 finally finally RB cord-010092-uftc8inx 8604 6 confirmed confirm VBN cord-010092-uftc8inx 8604 7 as as IN cord-010092-uftc8inx 8604 8 normal normal JJ cord-010092-uftc8inx 8604 9 ABO ABO NNP cord-010092-uftc8inx 8604 10 genotypes genotype NNS cord-010092-uftc8inx 8604 11 . . . cord-010092-uftc8inx 8605 1 No no DT cord-010092-uftc8inx 8605 2 statistical statistical JJ cord-010092-uftc8inx 8605 3 significance significance NN cord-010092-uftc8inx 8605 4 ( ( -LRB- cord-010092-uftc8inx 8605 5 86.3 86.3 CD cord-010092-uftc8inx 8605 6 % % NN cord-010092-uftc8inx 8605 7 vs vs IN cord-010092-uftc8inx 8605 8 75.9 75.9 CD cord-010092-uftc8inx 8605 9 % % NN cord-010092-uftc8inx 8605 10 , , , cord-010092-uftc8inx 8605 11 P p NN cord-010092-uftc8inx 8605 12 > > XX cord-010092-uftc8inx 8605 13 0.05 0.05 CD cord-010092-uftc8inx 8605 14 ) ) -RRB- cord-010092-uftc8inx 8605 15 in in IN cord-010092-uftc8inx 8605 16 the the DT cord-010092-uftc8inx 8605 17 frequency frequency NN cord-010092-uftc8inx 8605 18 of of IN cord-010092-uftc8inx 8605 19 strengthened strengthen VBN cord-010092-uftc8inx 8605 20 H h NN cord-010092-uftc8inx 8605 21 antigen antigen NN cord-010092-uftc8inx 8605 22 expressions expression NNS cord-010092-uftc8inx 8605 23 was be VBD cord-010092-uftc8inx 8605 24 observed observe VBN cord-010092-uftc8inx 8605 25 between between IN cord-010092-uftc8inx 8605 26 donors donor NNS cord-010092-uftc8inx 8605 27 and and CC cord-010092-uftc8inx 8605 28 hemopathic hemopathic JJ cord-010092-uftc8inx 8605 29 patients patient NNS cord-010092-uftc8inx 8605 30 . . . cord-010092-uftc8inx 8606 1 The the DT cord-010092-uftc8inx 8606 2 total total JJ cord-010092-uftc8inx 8606 3 number number NN cord-010092-uftc8inx 8606 4 of of IN cord-010092-uftc8inx 8606 5 subgroups subgroup NNS cord-010092-uftc8inx 8606 6 is be VBZ cord-010092-uftc8inx 8606 7 50 50 CD cord-010092-uftc8inx 8606 8 and and CC cord-010092-uftc8inx 8606 9 3 3 CD cord-010092-uftc8inx 8606 10 respectively respectively RB cord-010092-uftc8inx 8606 11 in in IN cord-010092-uftc8inx 8606 12 blood blood NN cord-010092-uftc8inx 8606 13 donors donor NNS cord-010092-uftc8inx 8606 14 and and CC cord-010092-uftc8inx 8606 15 hemopathic hemopathic JJ cord-010092-uftc8inx 8606 16 patients patient NNS cord-010092-uftc8inx 8606 17 . . . cord-010092-uftc8inx 8607 1 Extremely extremely RB cord-010092-uftc8inx 8607 2 significant significant JJ cord-010092-uftc8inx 8607 3 statistical statistical JJ cord-010092-uftc8inx 8607 4 differences difference NNS cord-010092-uftc8inx 8607 5 ( ( -LRB- cord-010092-uftc8inx 8607 6 68.1 68.1 CD cord-010092-uftc8inx 8607 7 % % NN cord-010092-uftc8inx 8607 8 vs vs IN cord-010092-uftc8inx 8607 9 13.6 13.6 CD cord-010092-uftc8inx 8607 10 % % NN cord-010092-uftc8inx 8607 11 , , , cord-010092-uftc8inx 8607 12 P p NN cord-010092-uftc8inx 8607 13 < < XX cord-010092-uftc8inx 8607 14 0.005 0.005 CD cord-010092-uftc8inx 8607 15 ) ) -RRB- cord-010092-uftc8inx 8607 16 existed exist VBD cord-010092-uftc8inx 8607 17 in in IN cord-010092-uftc8inx 8607 18 the the DT cord-010092-uftc8inx 8607 19 frequency frequency NN cord-010092-uftc8inx 8607 20 of of IN cord-010092-uftc8inx 8607 21 subgroups subgroup NNS cord-010092-uftc8inx 8607 22 with with IN cord-010092-uftc8inx 8607 23 enhanced enhanced JJ cord-010092-uftc8inx 8607 24 H h NN cord-010092-uftc8inx 8607 25 antigen antigen NN cord-010092-uftc8inx 8607 26 , , , cord-010092-uftc8inx 8607 27 which which WDT cord-010092-uftc8inx 8607 28 meant mean VBD cord-010092-uftc8inx 8607 29 the the DT cord-010092-uftc8inx 8607 30 possibility possibility NN cord-010092-uftc8inx 8607 31 of of IN cord-010092-uftc8inx 8607 32 subgroups subgroup NNS cord-010092-uftc8inx 8607 33 in in IN cord-010092-uftc8inx 8607 34 hemopathic hemopathic JJ cord-010092-uftc8inx 8607 35 patients patient NNS cord-010092-uftc8inx 8607 36 samples sample NNS cord-010092-uftc8inx 8607 37 was be VBD cord-010092-uftc8inx 8607 38 less less JJR cord-010092-uftc8inx 8607 39 . . . cord-010092-uftc8inx 8608 1 Summary Summary NNP cord-010092-uftc8inx 8608 2 / / SYM cord-010092-uftc8inx 8608 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 8608 4 : : : cord-010092-uftc8inx 8609 1 The the DT cord-010092-uftc8inx 8609 2 expression expression NN cord-010092-uftc8inx 8609 3 of of IN cord-010092-uftc8inx 8609 4 H h NN cord-010092-uftc8inx 8609 5 antigen antigen NN cord-010092-uftc8inx 8609 6 is be VBZ cord-010092-uftc8inx 8609 7 comparably comparably RB cord-010092-uftc8inx 8609 8 enhanced enhance VBN cord-010092-uftc8inx 8609 9 in in IN cord-010092-uftc8inx 8609 10 subgroups subgroup NNS cord-010092-uftc8inx 8609 11 and and CC cord-010092-uftc8inx 8609 12 hemopathies hemopathie NNS cord-010092-uftc8inx 8609 13 . . . cord-010092-uftc8inx 8610 1 But but CC cord-010092-uftc8inx 8610 2 most most JJS cord-010092-uftc8inx 8610 3 of of IN cord-010092-uftc8inx 8610 4 hemopathic hemopathic JJ cord-010092-uftc8inx 8610 5 patients patient NNS cord-010092-uftc8inx 8610 6 with with IN cord-010092-uftc8inx 8610 7 strengthened strengthen VBN cord-010092-uftc8inx 8610 8 H h NN cord-010092-uftc8inx 8610 9 antigen antigen NN cord-010092-uftc8inx 8610 10 expression expression NN cord-010092-uftc8inx 8610 11 present present JJ cord-010092-uftc8inx 8610 12 normal normal JJ cord-010092-uftc8inx 8610 13 ABO ABO NNP cord-010092-uftc8inx 8610 14 genotypes genotype NNS cord-010092-uftc8inx 8610 15 . . . cord-010092-uftc8inx 8611 1 As as IN cord-010092-uftc8inx 8611 2 a a DT cord-010092-uftc8inx 8611 3 result result NN cord-010092-uftc8inx 8611 4 , , , cord-010092-uftc8inx 8611 5 the the DT cord-010092-uftc8inx 8611 6 enhanced enhance VBN cord-010092-uftc8inx 8611 7 reaction reaction NN cord-010092-uftc8inx 8611 8 with with IN cord-010092-uftc8inx 8611 9 anti anti JJ cord-010092-uftc8inx 8611 10 - - NN cord-010092-uftc8inx 8611 11 H H NNP cord-010092-uftc8inx 8611 12 is be VBZ cord-010092-uftc8inx 8611 13 necessary necessary JJ cord-010092-uftc8inx 8611 14 but but CC cord-010092-uftc8inx 8611 15 not not RB cord-010092-uftc8inx 8611 16 sufficient sufficient JJ cord-010092-uftc8inx 8611 17 for for IN cord-010092-uftc8inx 8611 18 serological serological JJ cord-010092-uftc8inx 8611 19 identification identification NN cord-010092-uftc8inx 8611 20 of of IN cord-010092-uftc8inx 8611 21 ABO ABO NNP cord-010092-uftc8inx 8611 22 subgroups subgroup NNS cord-010092-uftc8inx 8611 23 in in IN cord-010092-uftc8inx 8611 24 hemopathic hemopathic JJ cord-010092-uftc8inx 8611 25 patients patient NNS cord-010092-uftc8inx 8611 26 . . . cord-010092-uftc8inx 8612 1 Background background NN cord-010092-uftc8inx 8612 2 : : : cord-010092-uftc8inx 8613 1 Although although IN cord-010092-uftc8inx 8613 2 the the DT cord-010092-uftc8inx 8613 3 use use NN cord-010092-uftc8inx 8613 4 of of IN cord-010092-uftc8inx 8613 5 automated automated JJ cord-010092-uftc8inx 8613 6 blood blood NN cord-010092-uftc8inx 8613 7 bank bank NN cord-010092-uftc8inx 8613 8 analyzer analyzer NN cord-010092-uftc8inx 8613 9 with with IN cord-010092-uftc8inx 8613 10 the the DT cord-010092-uftc8inx 8613 11 advantages advantage NNS cord-010092-uftc8inx 8613 12 of of IN cord-010092-uftc8inx 8613 13 speed speed NN cord-010092-uftc8inx 8613 14 and and CC cord-010092-uftc8inx 8613 15 efficiency efficiency NN cord-010092-uftc8inx 8613 16 has have VBZ cord-010092-uftc8inx 8613 17 recently recently RB cord-010092-uftc8inx 8613 18 increased increase VBN cord-010092-uftc8inx 8613 19 , , , cord-010092-uftc8inx 8613 20 the the DT cord-010092-uftc8inx 8613 21 ABO ABO NNP cord-010092-uftc8inx 8613 22 discrepancies discrepancy NNS cord-010092-uftc8inx 8613 23 in in IN cord-010092-uftc8inx 8613 24 automated automated JJ cord-010092-uftc8inx 8613 25 blood blood NN cord-010092-uftc8inx 8613 26 bank bank NN cord-010092-uftc8inx 8613 27 analyzer analyzer NN cord-010092-uftc8inx 8613 28 have have VBP cord-010092-uftc8inx 8613 29 caused cause VBN cord-010092-uftc8inx 8613 30 the the DT cord-010092-uftc8inx 8613 31 reporting reporting NN cord-010092-uftc8inx 8613 32 delays delay NNS cord-010092-uftc8inx 8613 33 of of IN cord-010092-uftc8inx 8613 34 the the DT cord-010092-uftc8inx 8613 35 results result NNS cord-010092-uftc8inx 8613 36 and and CC cord-010092-uftc8inx 8613 37 increase increase NN cord-010092-uftc8inx 8613 38 of of IN cord-010092-uftc8inx 8613 39 the the DT cord-010092-uftc8inx 8613 40 task task NN cord-010092-uftc8inx 8613 41 . . . cord-010092-uftc8inx 8614 1 Aims aim VBZ cord-010092-uftc8inx 8614 2 : : : cord-010092-uftc8inx 8615 1 We -PRON- PRP cord-010092-uftc8inx 8615 2 analyzed analyze VBD cord-010092-uftc8inx 8615 3 the the DT cord-010092-uftc8inx 8615 4 causes cause NNS cord-010092-uftc8inx 8615 5 of of IN cord-010092-uftc8inx 8615 6 ABO ABO NNP cord-010092-uftc8inx 8615 7 discrepancies discrepancy NNS cord-010092-uftc8inx 8615 8 in in IN cord-010092-uftc8inx 8615 9 automated automated JJ cord-010092-uftc8inx 8615 10 blood blood NN cord-010092-uftc8inx 8615 11 bank bank NN cord-010092-uftc8inx 8615 12 analyzer analyzer NN cord-010092-uftc8inx 8615 13 and and CC cord-010092-uftc8inx 8615 14 suggested suggest VBD cord-010092-uftc8inx 8615 15 a a DT cord-010092-uftc8inx 8615 16 solution solution NN cord-010092-uftc8inx 8615 17 strategy strategy NN cord-010092-uftc8inx 8615 18 based base VBN cord-010092-uftc8inx 8615 19 on on IN cord-010092-uftc8inx 8615 20 the the DT cord-010092-uftc8inx 8615 21 causes cause NNS cord-010092-uftc8inx 8615 22 . . . cord-010092-uftc8inx 8616 1 Methods method NNS cord-010092-uftc8inx 8616 2 : : : cord-010092-uftc8inx 8617 1 From from IN cord-010092-uftc8inx 8617 2 November November NNP cord-010092-uftc8inx 8617 3 2018 2018 CD cord-010092-uftc8inx 8617 4 to to IN cord-010092-uftc8inx 8617 5 January January NNP cord-010092-uftc8inx 8617 6 2019 2019 CD cord-010092-uftc8inx 8617 7 , , , cord-010092-uftc8inx 8617 8 55 55 CD cord-010092-uftc8inx 8617 9 cases case NNS cord-010092-uftc8inx 8617 10 ( ( -LRB- cord-010092-uftc8inx 8617 11 0.6 0.6 CD cord-010092-uftc8inx 8617 12 % % NN cord-010092-uftc8inx 8617 13 ) ) -RRB- cord-010092-uftc8inx 8617 14 of of IN cord-010092-uftc8inx 8617 15 ABO ABO NNP cord-010092-uftc8inx 8617 16 discrepancies discrepancy NNS cord-010092-uftc8inx 8617 17 among among IN cord-010092-uftc8inx 8617 18 9,550 9,550 CD cord-010092-uftc8inx 8617 19 ABO ABO NNP cord-010092-uftc8inx 8617 20 blood blood NN cord-010092-uftc8inx 8617 21 type type NN cord-010092-uftc8inx 8617 22 tests test NNS cord-010092-uftc8inx 8617 23 performed perform VBN cord-010092-uftc8inx 8617 24 using use VBG cord-010092-uftc8inx 8617 25 the the DT cord-010092-uftc8inx 8617 26 15-min 15-min CD cord-010092-uftc8inx 8617 27 reaction reaction NN cord-010092-uftc8inx 8617 28 mode mode NN cord-010092-uftc8inx 8617 29 of of IN cord-010092-uftc8inx 8617 30 IH-500 IH-500 NNP cord-010092-uftc8inx 8617 31 in in IN cord-010092-uftc8inx 8617 32 Chonbuk Chonbuk NNP cord-010092-uftc8inx 8617 33 National National NNP cord-010092-uftc8inx 8617 34 University University NNP cord-010092-uftc8inx 8617 35 Hospital Hospital NNP cord-010092-uftc8inx 8617 36 blood blood NN cord-010092-uftc8inx 8617 37 bank bank NN cord-010092-uftc8inx 8617 38 were be VBD cord-010092-uftc8inx 8617 39 identified identify VBN cord-010092-uftc8inx 8617 40 . . . cord-010092-uftc8inx 8618 1 We -PRON- PRP cord-010092-uftc8inx 8618 2 compared compare VBD cord-010092-uftc8inx 8618 3 the the DT cord-010092-uftc8inx 8618 4 test test NN cord-010092-uftc8inx 8618 5 results result NNS cord-010092-uftc8inx 8618 6 of of IN cord-010092-uftc8inx 8618 7 15-min 15-min CD cord-010092-uftc8inx 8618 8 mode mode NN cord-010092-uftc8inx 8618 9 with with IN cord-010092-uftc8inx 8618 10 results result NNS cord-010092-uftc8inx 8618 11 of of IN cord-010092-uftc8inx 8618 12 immediate immediate JJ cord-010092-uftc8inx 8618 13 mode mode NN cord-010092-uftc8inx 8618 14 using use VBG cord-010092-uftc8inx 8618 15 different different JJ cord-010092-uftc8inx 8618 16 red red JJ cord-010092-uftc8inx 8618 17 cell cell NN cord-010092-uftc8inx 8618 18 reagents reagent NNS cord-010092-uftc8inx 8618 19 , , , cord-010092-uftc8inx 8618 20 and and CC cord-010092-uftc8inx 8618 21 analyzed analyze VBD cord-010092-uftc8inx 8618 22 the the DT cord-010092-uftc8inx 8618 23 causes cause NNS cord-010092-uftc8inx 8618 24 of of IN cord-010092-uftc8inx 8618 25 discrepancies discrepancy NNS cord-010092-uftc8inx 8618 26 by by IN cord-010092-uftc8inx 8618 27 performing perform VBG cord-010092-uftc8inx 8618 28 additional additional JJ cord-010092-uftc8inx 8618 29 tests test NNS cord-010092-uftc8inx 8618 30 such such JJ cord-010092-uftc8inx 8618 31 as as IN cord-010092-uftc8inx 8618 32 microscopy microscopy NN cord-010092-uftc8inx 8618 33 , , , cord-010092-uftc8inx 8618 34 auto auto NN cord-010092-uftc8inx 8618 35 - - HYPH cord-010092-uftc8inx 8618 36 control control NN cord-010092-uftc8inx 8618 37 , , , cord-010092-uftc8inx 8618 38 antibody antibody NN cord-010092-uftc8inx 8618 39 screening screening NN cord-010092-uftc8inx 8618 40 and and CC cord-010092-uftc8inx 8618 41 identification identification NN cord-010092-uftc8inx 8618 42 , , , cord-010092-uftc8inx 8618 43 anti anti JJ cord-010092-uftc8inx 8618 44 - - NNP cord-010092-uftc8inx 8618 45 A1 A1 NNP cord-010092-uftc8inx 8618 46 and and CC cord-010092-uftc8inx 8618 47 ABO ABO NNP cord-010092-uftc8inx 8618 48 genotyping genotyping NN cord-010092-uftc8inx 8618 49 . . . cord-010092-uftc8inx 8619 1 Results result NNS cord-010092-uftc8inx 8619 2 : : : cord-010092-uftc8inx 8620 1 In in IN cord-010092-uftc8inx 8620 2 the the DT cord-010092-uftc8inx 8620 3 immediate immediate JJ cord-010092-uftc8inx 8620 4 reaction reaction NN cord-010092-uftc8inx 8620 5 using use VBG cord-010092-uftc8inx 8620 6 different different JJ cord-010092-uftc8inx 8620 7 red red JJ cord-010092-uftc8inx 8620 8 cell cell NN cord-010092-uftc8inx 8620 9 reagents reagent NNS cord-010092-uftc8inx 8620 10 , , , cord-010092-uftc8inx 8620 11 45 45 CD cord-010092-uftc8inx 8620 12 cases case NNS cord-010092-uftc8inx 8620 13 ( ( -LRB- cord-010092-uftc8inx 8620 14 81.8 81.8 CD cord-010092-uftc8inx 8620 15 % % NN cord-010092-uftc8inx 8620 16 ) ) -RRB- cord-010092-uftc8inx 8620 17 of of IN cord-010092-uftc8inx 8620 18 discrepancies discrepancy NNS cord-010092-uftc8inx 8620 19 disappeared disappear VBD cord-010092-uftc8inx 8620 20 and and CC cord-010092-uftc8inx 8620 21 10 10 CD cord-010092-uftc8inx 8620 22 cases case NNS cord-010092-uftc8inx 8620 23 ( ( -LRB- cord-010092-uftc8inx 8620 24 18.2 18.2 CD cord-010092-uftc8inx 8620 25 % % NN cord-010092-uftc8inx 8620 26 ) ) -RRB- cord-010092-uftc8inx 8620 27 remained remain VBD cord-010092-uftc8inx 8620 28 discrepancies discrepancy NNS cord-010092-uftc8inx 8620 29 . . . cord-010092-uftc8inx 8621 1 All all DT cord-010092-uftc8inx 8621 2 ABO ABO NNP cord-010092-uftc8inx 8621 3 discrepancies discrepancy NNS cord-010092-uftc8inx 8621 4 observed observe VBN cord-010092-uftc8inx 8621 5 in in IN cord-010092-uftc8inx 8621 6 the the DT cord-010092-uftc8inx 8621 7 15-min 15-min CD cord-010092-uftc8inx 8621 8 reaction reaction NN cord-010092-uftc8inx 8621 9 were be VBD cord-010092-uftc8inx 8621 10 due due JJ cord-010092-uftc8inx 8621 11 to to IN cord-010092-uftc8inx 8621 12 serum serum NN cord-010092-uftc8inx 8621 13 side side NN cord-010092-uftc8inx 8621 14 causes cause NNS cord-010092-uftc8inx 8621 15 , , , cord-010092-uftc8inx 8621 16 and and CC cord-010092-uftc8inx 8621 17 one one CD cord-010092-uftc8inx 8621 18 case case NN cord-010092-uftc8inx 8621 19 ( ( -LRB- cord-010092-uftc8inx 8621 20 1.8 1.8 CD cord-010092-uftc8inx 8621 21 % % NN cord-010092-uftc8inx 8621 22 ) ) -RRB- cord-010092-uftc8inx 8621 23 was be VBD cord-010092-uftc8inx 8621 24 due due JJ cord-010092-uftc8inx 8621 25 to to IN cord-010092-uftc8inx 8621 26 both both DT cord-010092-uftc8inx 8621 27 of of IN cord-010092-uftc8inx 8621 28 serum serum NN cord-010092-uftc8inx 8621 29 and and CC cord-010092-uftc8inx 8621 30 red red JJ cord-010092-uftc8inx 8621 31 cells cell NNS cord-010092-uftc8inx 8621 32 side side NN cord-010092-uftc8inx 8621 33 cause cause NN cord-010092-uftc8inx 8621 34 . . . cord-010092-uftc8inx 8622 1 Nonspecific nonspecific JJ cord-010092-uftc8inx 8622 2 response response NN cord-010092-uftc8inx 8622 3 ( ( -LRB- cord-010092-uftc8inx 8622 4 28 28 CD cord-010092-uftc8inx 8622 5 cases case NNS cord-010092-uftc8inx 8622 6 , , , cord-010092-uftc8inx 8622 7 50.9 50.9 CD cord-010092-uftc8inx 8622 8 % % NN cord-010092-uftc8inx 8622 9 ) ) -RRB- cord-010092-uftc8inx 8622 10 , , , cord-010092-uftc8inx 8622 11 cold cold JJ cord-010092-uftc8inx 8622 12 antibody antibody NN cord-010092-uftc8inx 8622 13 ( ( -LRB- cord-010092-uftc8inx 8622 14 20 20 CD cord-010092-uftc8inx 8622 15 cases case NNS cord-010092-uftc8inx 8622 16 , , , cord-010092-uftc8inx 8622 17 36.4 36.4 CD cord-010092-uftc8inx 8622 18 % % NN cord-010092-uftc8inx 8622 19 ) ) -RRB- cord-010092-uftc8inx 8622 20 , , , cord-010092-uftc8inx 8622 21 rouleaux rouleaux JJ cord-010092-uftc8inx 8622 22 formation formation NN cord-010092-uftc8inx 8622 23 ( ( -LRB- cord-010092-uftc8inx 8622 24 3 3 CD cord-010092-uftc8inx 8622 25 cases case NNS cord-010092-uftc8inx 8622 26 , , , cord-010092-uftc8inx 8622 27 5.5 5.5 CD cord-010092-uftc8inx 8622 28 % % NN cord-010092-uftc8inx 8622 29 ) ) -RRB- cord-010092-uftc8inx 8622 30 , , , cord-010092-uftc8inx 8622 31 cis cis NNP cord-010092-uftc8inx 8622 32 - - HYPH cord-010092-uftc8inx 8622 33 AB AB NNP cord-010092-uftc8inx 8622 34 ( ( -LRB- cord-010092-uftc8inx 8622 35 3 3 CD cord-010092-uftc8inx 8622 36 cases case NNS cord-010092-uftc8inx 8622 37 , , , cord-010092-uftc8inx 8622 38 5.5 5.5 CD cord-010092-uftc8inx 8622 39 % % NN cord-010092-uftc8inx 8622 40 ) ) -RRB- cord-010092-uftc8inx 8622 41 , , , cord-010092-uftc8inx 8622 42 and and CC cord-010092-uftc8inx 8622 43 ABO ABO NNP cord-010092-uftc8inx 8622 44 subtype subtype NN cord-010092-uftc8inx 8622 45 ( ( -LRB- cord-010092-uftc8inx 8622 46 1 1 CD cord-010092-uftc8inx 8622 47 case case NN cord-010092-uftc8inx 8622 48 , , , cord-010092-uftc8inx 8622 49 1.8 1.8 CD cord-010092-uftc8inx 8622 50 % % NN cord-010092-uftc8inx 8622 51 ) ) -RRB- cord-010092-uftc8inx 8622 52 were be VBD cord-010092-uftc8inx 8622 53 analyzed analyze VBN cord-010092-uftc8inx 8622 54 as as IN cord-010092-uftc8inx 8622 55 causes cause NNS cord-010092-uftc8inx 8622 56 of of IN cord-010092-uftc8inx 8622 57 discrepancies discrepancy NNS cord-010092-uftc8inx 8622 58 . . . cord-010092-uftc8inx 8623 1 One one CD cord-010092-uftc8inx 8623 2 discrepancy discrepancy NN cord-010092-uftc8inx 8623 3 due due JJ cord-010092-uftc8inx 8623 4 to to IN cord-010092-uftc8inx 8623 5 cis cis NNP cord-010092-uftc8inx 8623 6 - - HYPH cord-010092-uftc8inx 8623 7 AB AB NNP cord-010092-uftc8inx 8623 8 was be VBD cord-010092-uftc8inx 8623 9 disappeared disappear VBN cord-010092-uftc8inx 8623 10 in in IN cord-010092-uftc8inx 8623 11 the the DT cord-010092-uftc8inx 8623 12 immediate immediate JJ cord-010092-uftc8inx 8623 13 reaction reaction NN cord-010092-uftc8inx 8623 14 using use VBG cord-010092-uftc8inx 8623 15 different different JJ cord-010092-uftc8inx 8623 16 red red JJ cord-010092-uftc8inx 8623 17 cell cell NN cord-010092-uftc8inx 8623 18 reagents reagent NNS cord-010092-uftc8inx 8623 19 , , , cord-010092-uftc8inx 8623 20 ABO ABO NNP cord-010092-uftc8inx 8623 21 subtype subtype NN cord-010092-uftc8inx 8623 22 was be VBD cord-010092-uftc8inx 8623 23 changed change VBN cord-010092-uftc8inx 8623 24 to to IN cord-010092-uftc8inx 8623 25 totally totally RB cord-010092-uftc8inx 8623 26 different different JJ cord-010092-uftc8inx 8623 27 blood blood NN cord-010092-uftc8inx 8623 28 group group NN cord-010092-uftc8inx 8623 29 , , , cord-010092-uftc8inx 8623 30 A. a. NN cord-010092-uftc8inx 8624 1 On on IN cord-010092-uftc8inx 8624 2 the the DT cord-010092-uftc8inx 8624 3 other other JJ cord-010092-uftc8inx 8624 4 hand hand NN cord-010092-uftc8inx 8624 5 , , , cord-010092-uftc8inx 8624 6 in in IN cord-010092-uftc8inx 8624 7 cases case NNS cord-010092-uftc8inx 8624 8 of of IN cord-010092-uftc8inx 8624 9 the the DT cord-010092-uftc8inx 8624 10 discrepancy discrepancy NN cord-010092-uftc8inx 8624 11 corrected correct VBN cord-010092-uftc8inx 8624 12 by by IN cord-010092-uftc8inx 8624 13 the the DT cord-010092-uftc8inx 8624 14 immediate immediate JJ cord-010092-uftc8inx 8624 15 reaction reaction NN cord-010092-uftc8inx 8624 16 using use VBG cord-010092-uftc8inx 8624 17 different different JJ cord-010092-uftc8inx 8624 18 red red JJ cord-010092-uftc8inx 8624 19 cell cell NN cord-010092-uftc8inx 8624 20 reagents reagent NNS cord-010092-uftc8inx 8624 21 , , , cord-010092-uftc8inx 8624 22 the the DT cord-010092-uftc8inx 8624 23 intensity intensity NN cord-010092-uftc8inx 8624 24 of of IN cord-010092-uftc8inx 8624 25 the the DT cord-010092-uftc8inx 8624 26 positive positive JJ cord-010092-uftc8inx 8624 27 results result NNS cord-010092-uftc8inx 8624 28 still still RB cord-010092-uftc8inx 8624 29 observed observe VBN cord-010092-uftc8inx 8624 30 in in IN cord-010092-uftc8inx 8624 31 immediate immediate JJ cord-010092-uftc8inx 8624 32 reaction reaction NN cord-010092-uftc8inx 8624 33 was be VBD cord-010092-uftc8inx 8624 34 not not RB cord-010092-uftc8inx 8624 35 different different JJ cord-010092-uftc8inx 8624 36 from from IN cord-010092-uftc8inx 8624 37 the the DT cord-010092-uftc8inx 8624 38 15-min 15-min CD cord-010092-uftc8inx 8624 39 reaction reaction NN cord-010092-uftc8inx 8624 40 . . . cord-010092-uftc8inx 8625 1 Summary Summary NNP cord-010092-uftc8inx 8625 2 / / SYM cord-010092-uftc8inx 8625 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 8625 4 : : : cord-010092-uftc8inx 8626 1 IH-500 IH-500 NNP cord-010092-uftc8inx 8626 2 , , , cord-010092-uftc8inx 8626 3 an an DT cord-010092-uftc8inx 8626 4 automated automate VBN cord-010092-uftc8inx 8626 5 blood blood NN cord-010092-uftc8inx 8626 6 bank bank NN cord-010092-uftc8inx 8626 7 analyzer analyzer NN cord-010092-uftc8inx 8626 8 , , , cord-010092-uftc8inx 8626 9 was be VBD cord-010092-uftc8inx 8626 10 considered consider VBN cord-010092-uftc8inx 8626 11 useful useful JJ cord-010092-uftc8inx 8626 12 for for IN cord-010092-uftc8inx 8626 13 automation automation NN cord-010092-uftc8inx 8626 14 of of IN cord-010092-uftc8inx 8626 15 ABO ABO NNP cord-010092-uftc8inx 8626 16 blood blood NN cord-010092-uftc8inx 8626 17 typing typing NN cord-010092-uftc8inx 8626 18 , , , cord-010092-uftc8inx 8626 19 and and CC cord-010092-uftc8inx 8626 20 some some DT cord-010092-uftc8inx 8626 21 observable observable JJ cord-010092-uftc8inx 8626 22 ABO ABO NNP cord-010092-uftc8inx 8626 23 discrepancies discrepancy NNS cord-010092-uftc8inx 8626 24 are be VBP cord-010092-uftc8inx 8626 25 expected expect VBN cord-010092-uftc8inx 8626 26 to to TO cord-010092-uftc8inx 8626 27 be be VB cord-010092-uftc8inx 8626 28 mostly mostly RB cord-010092-uftc8inx 8626 29 addressed address VBN cord-010092-uftc8inx 8626 30 by by IN cord-010092-uftc8inx 8626 31 reexamining reexamine VBG cord-010092-uftc8inx 8626 32 with with IN cord-010092-uftc8inx 8626 33 immediate immediate JJ cord-010092-uftc8inx 8626 34 reaction reaction NN cord-010092-uftc8inx 8626 35 mode mode NN cord-010092-uftc8inx 8626 36 using use VBG cord-010092-uftc8inx 8626 37 different different JJ cord-010092-uftc8inx 8626 38 red red JJ cord-010092-uftc8inx 8626 39 cell cell NN cord-010092-uftc8inx 8626 40 reagents reagent NNS cord-010092-uftc8inx 8626 41 . . . cord-010092-uftc8inx 8627 1 Abstract Abstract NNP cord-010092-uftc8inx 8627 2 withdrawn withdraw VBN cord-010092-uftc8inx 8627 3 . . . cord-010092-uftc8inx 8628 1 Background background NN cord-010092-uftc8inx 8628 2 : : : cord-010092-uftc8inx 8629 1 ABO ABO NNP cord-010092-uftc8inx 8629 2 blood blood NN cord-010092-uftc8inx 8629 3 group group NN cord-010092-uftc8inx 8629 4 antigens antigen NNS cord-010092-uftc8inx 8629 5 mainly mainly RB cord-010092-uftc8inx 8629 6 expressed express VBN cord-010092-uftc8inx 8629 7 on on IN cord-010092-uftc8inx 8629 8 red red JJ cord-010092-uftc8inx 8629 9 blood blood NN cord-010092-uftc8inx 8629 10 cells cell NNS cord-010092-uftc8inx 8629 11 , , , cord-010092-uftc8inx 8629 12 but but CC cord-010092-uftc8inx 8629 13 along along IN cord-010092-uftc8inx 8629 14 with with IN cord-010092-uftc8inx 8629 15 that that DT cord-010092-uftc8inx 8629 16 they -PRON- PRP cord-010092-uftc8inx 8629 17 also also RB cord-010092-uftc8inx 8629 18 present present VBP cord-010092-uftc8inx 8629 19 on on IN cord-010092-uftc8inx 8629 20 many many JJ cord-010092-uftc8inx 8629 21 organs organ NNS cord-010092-uftc8inx 8629 22 and and CC cord-010092-uftc8inx 8629 23 tissues tissue NNS cord-010092-uftc8inx 8629 24 like like IN cord-010092-uftc8inx 8629 25 epithelia epithelium NNS cord-010092-uftc8inx 8629 26 , , , cord-010092-uftc8inx 8629 27 platelets platelet NNS cord-010092-uftc8inx 8629 28 , , , cord-010092-uftc8inx 8629 29 vascular vascular JJ cord-010092-uftc8inx 8629 30 endothelia endothelium NNS cord-010092-uftc8inx 8629 31 and and CC cord-010092-uftc8inx 8629 32 neurons neuron NNS cord-010092-uftc8inx 8629 33 etc etc FW cord-010092-uftc8inx 8629 34 . . . cord-010092-uftc8inx 8630 1 The the DT cord-010092-uftc8inx 8630 2 importance importance NN cord-010092-uftc8inx 8630 3 of of IN cord-010092-uftc8inx 8630 4 ABO ABO NNP cord-010092-uftc8inx 8630 5 antigens antigen NNS cord-010092-uftc8inx 8630 6 extends extend VBZ cord-010092-uftc8inx 8630 7 beyond beyond IN cord-010092-uftc8inx 8630 8 transfusion transfusion NN cord-010092-uftc8inx 8630 9 medicine medicine NN cord-010092-uftc8inx 8630 10 by by IN cord-010092-uftc8inx 8630 11 association association NN cord-010092-uftc8inx 8630 12 with with IN cord-010092-uftc8inx 8630 13 various various JJ cord-010092-uftc8inx 8630 14 systemic systemic JJ cord-010092-uftc8inx 8630 15 diseases disease NNS cord-010092-uftc8inx 8630 16 like like IN cord-010092-uftc8inx 8630 17 cardiovascular cardiovascular JJ cord-010092-uftc8inx 8630 18 diseases disease NNS cord-010092-uftc8inx 8630 19 , , , cord-010092-uftc8inx 8630 20 gastric gastric JJ cord-010092-uftc8inx 8630 21 diseases disease NNS cord-010092-uftc8inx 8630 22 , , , cord-010092-uftc8inx 8630 23 cancers cancer NNS cord-010092-uftc8inx 8630 24 , , , cord-010092-uftc8inx 8630 25 infectious infectious JJ cord-010092-uftc8inx 8630 26 diseases disease NNS cord-010092-uftc8inx 8630 27 etc etc FW cord-010092-uftc8inx 8630 28 has have VBZ cord-010092-uftc8inx 8630 29 been be VBN cord-010092-uftc8inx 8630 30 proven prove VBN cord-010092-uftc8inx 8630 31 previously previously RB cord-010092-uftc8inx 8630 32 . . . cord-010092-uftc8inx 8631 1 Previous previous JJ cord-010092-uftc8inx 8631 2 researchers researcher NNS cord-010092-uftc8inx 8631 3 also also RB cord-010092-uftc8inx 8631 4 tried try VBD cord-010092-uftc8inx 8631 5 to to TO cord-010092-uftc8inx 8631 6 find find VB cord-010092-uftc8inx 8631 7 out out RP cord-010092-uftc8inx 8631 8 the the DT cord-010092-uftc8inx 8631 9 involvement involvement NN cord-010092-uftc8inx 8631 10 of of IN cord-010092-uftc8inx 8631 11 ABO ABO NNP cord-010092-uftc8inx 8631 12 antigens antigen NNS cord-010092-uftc8inx 8631 13 in in IN cord-010092-uftc8inx 8631 14 neurological neurological JJ cord-010092-uftc8inx 8631 15 diseases disease NNS cord-010092-uftc8inx 8631 16 like like IN cord-010092-uftc8inx 8631 17 Alzheimer Alzheimer NNP cord-010092-uftc8inx 8631 18 's 's POS cord-010092-uftc8inx 8631 19 disease disease NN cord-010092-uftc8inx 8631 20 , , , cord-010092-uftc8inx 8631 21 Parkinson Parkinson NNP cord-010092-uftc8inx 8631 22 diseases disease NNS cord-010092-uftc8inx 8631 23 etc etc FW cord-010092-uftc8inx 8631 24 . . . cord-010092-uftc8inx 8632 1 but but CC cord-010092-uftc8inx 8632 2 association association NNP cord-010092-uftc8inx 8632 3 with with IN cord-010092-uftc8inx 8632 4 neurological neurological JJ cord-010092-uftc8inx 8632 5 tumours tumour NNS cord-010092-uftc8inx 8632 6 is be VBZ cord-010092-uftc8inx 8632 7 less less RBR cord-010092-uftc8inx 8632 8 explored explore VBN cord-010092-uftc8inx 8632 9 . . . cord-010092-uftc8inx 8633 1 Aims aim VBZ cord-010092-uftc8inx 8633 2 : : : cord-010092-uftc8inx 8634 1 This this DT cord-010092-uftc8inx 8634 2 study study NN cord-010092-uftc8inx 8634 3 aimed aim VBD cord-010092-uftc8inx 8634 4 to to TO cord-010092-uftc8inx 8634 5 analyse analyse VB cord-010092-uftc8inx 8634 6 the the DT cord-010092-uftc8inx 8634 7 association association NN cord-010092-uftc8inx 8634 8 of of IN cord-010092-uftc8inx 8634 9 ABO ABO NNP cord-010092-uftc8inx 8634 10 blood blood NN cord-010092-uftc8inx 8634 11 group group NN cord-010092-uftc8inx 8634 12 antigens antigen NNS cord-010092-uftc8inx 8634 13 with with IN cord-010092-uftc8inx 8634 14 neurological neurological JJ cord-010092-uftc8inx 8634 15 tumours tumour NNS cord-010092-uftc8inx 8634 16 . . . cord-010092-uftc8inx 8635 1 Methods method NNS cord-010092-uftc8inx 8635 2 : : : cord-010092-uftc8inx 8636 1 A a DT cord-010092-uftc8inx 8636 2 retrospective retrospective JJ cord-010092-uftc8inx 8636 3 study study NN cord-010092-uftc8inx 8636 4 in in IN cord-010092-uftc8inx 8636 5 a a DT cord-010092-uftc8inx 8636 6 tertiary tertiary JJ cord-010092-uftc8inx 8636 7 care care NN cord-010092-uftc8inx 8636 8 institute institute NN cord-010092-uftc8inx 8636 9 in in IN cord-010092-uftc8inx 8636 10 India India NNP cord-010092-uftc8inx 8636 11 analysed analyse VBD cord-010092-uftc8inx 8636 12 the the DT cord-010092-uftc8inx 8636 13 2 2 CD cord-010092-uftc8inx 8636 14 years year NNS cord-010092-uftc8inx 8636 15 data datum NNS cord-010092-uftc8inx 8636 16 from from IN cord-010092-uftc8inx 8636 17 Jan Jan NNP cord-010092-uftc8inx 8636 18 2017 2017 CD cord-010092-uftc8inx 8636 19 to to IN cord-010092-uftc8inx 8636 20 Dec Dec NNP cord-010092-uftc8inx 8636 21 2018 2018 CD cord-010092-uftc8inx 8636 22 . . . cord-010092-uftc8inx 8637 1 The the DT cord-010092-uftc8inx 8637 2 carcinoma carcinoma NN cord-010092-uftc8inx 8637 3 patient patient NN cord-010092-uftc8inx 8637 4 's 's POS cord-010092-uftc8inx 8637 5 admitted admit VBN cord-010092-uftc8inx 8637 6 in in IN cord-010092-uftc8inx 8637 7 neurosurgical neurosurgical JJ cord-010092-uftc8inx 8637 8 department department NN cord-010092-uftc8inx 8637 9 during during IN cord-010092-uftc8inx 8637 10 study study NN cord-010092-uftc8inx 8637 11 period period NN cord-010092-uftc8inx 8637 12 were be VBD cord-010092-uftc8inx 8637 13 included include VBN cord-010092-uftc8inx 8637 14 in in IN cord-010092-uftc8inx 8637 15 our -PRON- PRP$ cord-010092-uftc8inx 8637 16 study study NN cord-010092-uftc8inx 8637 17 . . . cord-010092-uftc8inx 8638 1 Their -PRON- PRP$ cord-010092-uftc8inx 8638 2 diagnosis diagnosis NN cord-010092-uftc8inx 8638 3 and and CC cord-010092-uftc8inx 8638 4 ABO ABO NNP cord-010092-uftc8inx 8638 5 blood blood NN cord-010092-uftc8inx 8638 6 groups group NNS cord-010092-uftc8inx 8638 7 were be VBD cord-010092-uftc8inx 8638 8 collected collect VBN cord-010092-uftc8inx 8638 9 from from IN cord-010092-uftc8inx 8638 10 hospital hospital NN cord-010092-uftc8inx 8638 11 information information NN cord-010092-uftc8inx 8638 12 system system NN cord-010092-uftc8inx 8638 13 . . . cord-010092-uftc8inx 8639 1 Data datum NNS cord-010092-uftc8inx 8639 2 were be VBD cord-010092-uftc8inx 8639 3 analysed analyse VBN cord-010092-uftc8inx 8639 4 into into IN cord-010092-uftc8inx 8639 5 Microsoft Microsoft NNP cord-010092-uftc8inx 8639 6 excel excel VB cord-010092-uftc8inx 8639 7 2016 2016 CD cord-010092-uftc8inx 8639 8 and and CC cord-010092-uftc8inx 8639 9 SPSS SPSS NNP cord-010092-uftc8inx 8639 10 ( ( -LRB- cord-010092-uftc8inx 8639 11 version version NN cord-010092-uftc8inx 8639 12 22 22 CD cord-010092-uftc8inx 8639 13 ) ) -RRB- cord-010092-uftc8inx 8639 14 . . . cord-010092-uftc8inx 8640 1 Results result NNS cord-010092-uftc8inx 8640 2 : : : cord-010092-uftc8inx 8641 1 During during IN cord-010092-uftc8inx 8641 2 study study NN cord-010092-uftc8inx 8641 3 period period NN cord-010092-uftc8inx 8641 4 a a DT cord-010092-uftc8inx 8641 5 total total NN cord-010092-uftc8inx 8641 6 of of IN cord-010092-uftc8inx 8641 7 1970 1970 CD cord-010092-uftc8inx 8641 8 patients patient NNS cord-010092-uftc8inx 8641 9 with with IN cord-010092-uftc8inx 8641 10 neurological neurological JJ cord-010092-uftc8inx 8641 11 tumours tumour NNS cord-010092-uftc8inx 8641 12 were be VBD cord-010092-uftc8inx 8641 13 admitted admit VBN cord-010092-uftc8inx 8641 14 in in IN cord-010092-uftc8inx 8641 15 our -PRON- PRP$ cord-010092-uftc8inx 8641 16 hospital hospital NN cord-010092-uftc8inx 8641 17 . . . cord-010092-uftc8inx 8642 1 The the DT cord-010092-uftc8inx 8642 2 blood blood NN cord-010092-uftc8inx 8642 3 group group NN cord-010092-uftc8inx 8642 4 frequency frequency NN cord-010092-uftc8inx 8642 5 of of IN cord-010092-uftc8inx 8642 6 these these DT cord-010092-uftc8inx 8642 7 patients patient NNS cord-010092-uftc8inx 8642 8 were be VBD cord-010092-uftc8inx 8642 9 20.91 20.91 CD cord-010092-uftc8inx 8642 10 % % NN cord-010092-uftc8inx 8642 11 , , , cord-010092-uftc8inx 8642 12 37.51 37.51 CD cord-010092-uftc8inx 8642 13 % % NN cord-010092-uftc8inx 8642 14 , , , cord-010092-uftc8inx 8642 15 32.74 32.74 CD cord-010092-uftc8inx 8642 16 % % NN cord-010092-uftc8inx 8642 17 , , , cord-010092-uftc8inx 8642 18 8.83 8.83 CD cord-010092-uftc8inx 8642 19 % % NN cord-010092-uftc8inx 8642 20 for for IN cord-010092-uftc8inx 8642 21 A a NN cord-010092-uftc8inx 8642 22 , , , cord-010092-uftc8inx 8642 23 B b NN cord-010092-uftc8inx 8642 24 , , , cord-010092-uftc8inx 8642 25 O o UH cord-010092-uftc8inx 8642 26 and and CC cord-010092-uftc8inx 8642 27 AB AB NNP cord-010092-uftc8inx 8642 28 respectively respectively RB cord-010092-uftc8inx 8642 29 . . . cord-010092-uftc8inx 8643 1 The the DT cord-010092-uftc8inx 8643 2 common common JJ cord-010092-uftc8inx 8643 3 neurological neurological JJ cord-010092-uftc8inx 8643 4 tumours tumour NNS cord-010092-uftc8inx 8643 5 found find VBN cord-010092-uftc8inx 8643 6 in in IN cord-010092-uftc8inx 8643 7 our -PRON- PRP$ cord-010092-uftc8inx 8643 8 study study NN cord-010092-uftc8inx 8643 9 were be VBD cord-010092-uftc8inx 8643 10 glioma glioma NN cord-010092-uftc8inx 8643 11 ( ( -LRB- cord-010092-uftc8inx 8643 12 33.55 33.55 CD cord-010092-uftc8inx 8643 13 % % NN cord-010092-uftc8inx 8643 14 ) ) -RRB- cord-010092-uftc8inx 8643 15 followed follow VBN cord-010092-uftc8inx 8643 16 by by IN cord-010092-uftc8inx 8643 17 pituitary pituitary JJ cord-010092-uftc8inx 8643 18 adenoma adenoma NN cord-010092-uftc8inx 8643 19 ( ( -LRB- cord-010092-uftc8inx 8643 20 20.05 20.05 CD cord-010092-uftc8inx 8643 21 % % NN cord-010092-uftc8inx 8643 22 ) ) -RRB- cord-010092-uftc8inx 8643 23 , , , cord-010092-uftc8inx 8643 24 meningioma meningioma NN cord-010092-uftc8inx 8643 25 ( ( -LRB- cord-010092-uftc8inx 8643 26 18.58 18.58 CD cord-010092-uftc8inx 8643 27 % % NN cord-010092-uftc8inx 8643 28 ) ) -RRB- cord-010092-uftc8inx 8643 29 , , , cord-010092-uftc8inx 8643 30 schwannoma schwannoma NNP cord-010092-uftc8inx 8643 31 ( ( -LRB- cord-010092-uftc8inx 8643 32 8.98 8.98 CD cord-010092-uftc8inx 8643 33 % % NN cord-010092-uftc8inx 8643 34 ) ) -RRB- cord-010092-uftc8inx 8643 35 , , , cord-010092-uftc8inx 8643 36 Cavernoma Cavernoma NNP cord-010092-uftc8inx 8643 37 ( ( -LRB- cord-010092-uftc8inx 8643 38 2.54 2.54 CD cord-010092-uftc8inx 8643 39 % % NN cord-010092-uftc8inx 8643 40 ) ) -RRB- cord-010092-uftc8inx 8643 41 , , , cord-010092-uftc8inx 8643 42 neuroma neuroma NN cord-010092-uftc8inx 8643 43 ( ( -LRB- cord-010092-uftc8inx 8643 44 2.23 2.23 CD cord-010092-uftc8inx 8643 45 % % NN cord-010092-uftc8inx 8643 46 ) ) -RRB- cord-010092-uftc8inx 8643 47 and and CC cord-010092-uftc8inx 8643 48 space space NN cord-010092-uftc8inx 8643 49 occupying occupy VBG cord-010092-uftc8inx 8643 50 lesions lesion NNS cord-010092-uftc8inx 8643 51 ( ( -LRB- cord-010092-uftc8inx 8643 52 14.06 14.06 CD cord-010092-uftc8inx 8643 53 % % NN cord-010092-uftc8inx 8643 54 ) ) -RRB- cord-010092-uftc8inx 8643 55 . . . cord-010092-uftc8inx 8644 1 The the DT cord-010092-uftc8inx 8644 2 prevalence prevalence NN cord-010092-uftc8inx 8644 3 of of IN cord-010092-uftc8inx 8644 4 ABO ABO NNP cord-010092-uftc8inx 8644 5 antigens antigen NNS cord-010092-uftc8inx 8644 6 was be VBD cord-010092-uftc8inx 8644 7 almost almost RB cord-010092-uftc8inx 8644 8 similar similar JJ cord-010092-uftc8inx 8644 9 in in IN cord-010092-uftc8inx 8644 10 all all DT cord-010092-uftc8inx 8644 11 neurological neurological JJ cord-010092-uftc8inx 8644 12 tumours tumour NNS cord-010092-uftc8inx 8644 13 except except IN cord-010092-uftc8inx 8644 14 in in IN cord-010092-uftc8inx 8644 15 neuroma neuroma NN cord-010092-uftc8inx 8644 16 . . . cord-010092-uftc8inx 8645 1 Neuroma Neuroma NNP cord-010092-uftc8inx 8645 2 was be VBD cord-010092-uftc8inx 8645 3 found find VBN cord-010092-uftc8inx 8645 4 in in IN cord-010092-uftc8inx 8645 5 47.73 47.73 CD cord-010092-uftc8inx 8645 6 % % NN cord-010092-uftc8inx 8645 7 O o NN cord-010092-uftc8inx 8645 8 group group NN cord-010092-uftc8inx 8645 9 patients patient NNS cord-010092-uftc8inx 8645 10 as as IN cord-010092-uftc8inx 8645 11 compared compare VBN cord-010092-uftc8inx 8645 12 to to IN cord-010092-uftc8inx 8645 13 other other JJ cord-010092-uftc8inx 8645 14 blood blood NN cord-010092-uftc8inx 8645 15 groups group NNS cord-010092-uftc8inx 8645 16 which which WDT cord-010092-uftc8inx 8645 17 was be VBD cord-010092-uftc8inx 8645 18 found find VBN cord-010092-uftc8inx 8645 19 statistically statistically RB cord-010092-uftc8inx 8645 20 significant significant JJ cord-010092-uftc8inx 8645 21 ( ( -LRB- cord-010092-uftc8inx 8645 22 P p NN cord-010092-uftc8inx 8645 23 < < XX cord-010092-uftc8inx 8645 24 0.05 0.05 CD cord-010092-uftc8inx 8645 25 ) ) -RRB- cord-010092-uftc8inx 8645 26 . . . cord-010092-uftc8inx 8646 1 Summary Summary NNP cord-010092-uftc8inx 8646 2 / / SYM cord-010092-uftc8inx 8646 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 8646 4 : : : cord-010092-uftc8inx 8647 1 In in IN cord-010092-uftc8inx 8647 2 this this DT cord-010092-uftc8inx 8647 3 study study NN cord-010092-uftc8inx 8647 4 we -PRON- PRP cord-010092-uftc8inx 8647 5 tried try VBD cord-010092-uftc8inx 8647 6 to to TO cord-010092-uftc8inx 8647 7 analyse analyse VB cord-010092-uftc8inx 8647 8 the the DT cord-010092-uftc8inx 8647 9 association association NN cord-010092-uftc8inx 8647 10 of of IN cord-010092-uftc8inx 8647 11 neurological neurological JJ cord-010092-uftc8inx 8647 12 tumours tumour NNS cord-010092-uftc8inx 8647 13 with with IN cord-010092-uftc8inx 8647 14 ABO ABO NNP cord-010092-uftc8inx 8647 15 blood blood NN cord-010092-uftc8inx 8647 16 groups group NNS cord-010092-uftc8inx 8647 17 antigens antigen NNS cord-010092-uftc8inx 8647 18 . . . cord-010092-uftc8inx 8648 1 We -PRON- PRP cord-010092-uftc8inx 8648 2 found find VBD cord-010092-uftc8inx 8648 3 there there EX cord-010092-uftc8inx 8648 4 is be VBZ cord-010092-uftc8inx 8648 5 no no DT cord-010092-uftc8inx 8648 6 association association NN cord-010092-uftc8inx 8648 7 of of IN cord-010092-uftc8inx 8648 8 neurological neurological JJ cord-010092-uftc8inx 8648 9 tumours tumour NNS cord-010092-uftc8inx 8648 10 with with IN cord-010092-uftc8inx 8648 11 ABO ABO NNP cord-010092-uftc8inx 8648 12 blood blood NN cord-010092-uftc8inx 8648 13 groups group NNS cord-010092-uftc8inx 8648 14 because because IN cord-010092-uftc8inx 8648 15 the the DT cord-010092-uftc8inx 8648 16 prevalence prevalence NN cord-010092-uftc8inx 8648 17 on on IN cord-010092-uftc8inx 8648 18 ABO ABO NNP cord-010092-uftc8inx 8648 19 group group NN cord-010092-uftc8inx 8648 20 in in IN cord-010092-uftc8inx 8648 21 general general JJ cord-010092-uftc8inx 8648 22 population population NN cord-010092-uftc8inx 8648 23 is be VBZ cord-010092-uftc8inx 8648 24 almost almost RB cord-010092-uftc8inx 8648 25 similar similar JJ cord-010092-uftc8inx 8648 26 in in IN cord-010092-uftc8inx 8648 27 patient patient NN cord-010092-uftc8inx 8648 28 with with IN cord-010092-uftc8inx 8648 29 neurological neurological JJ cord-010092-uftc8inx 8648 30 tumours tumour NNS cord-010092-uftc8inx 8648 31 except except IN cord-010092-uftc8inx 8648 32 neuroma neuroma NN cord-010092-uftc8inx 8648 33 . . . cord-010092-uftc8inx 8649 1 Neuroma Neuroma NNP cord-010092-uftc8inx 8649 2 group group NN cord-010092-uftc8inx 8649 3 of of IN cord-010092-uftc8inx 8649 4 tumours tumour NNS cord-010092-uftc8inx 8649 5 like like IN cord-010092-uftc8inx 8649 6 neurofibroma neurofibroma NNP cord-010092-uftc8inx 8649 7 , , , cord-010092-uftc8inx 8649 8 neuroblastoma neuroblastoma NN cord-010092-uftc8inx 8649 9 , , , cord-010092-uftc8inx 8649 10 nerve nerve NN cord-010092-uftc8inx 8649 11 tumours tumour NNS cord-010092-uftc8inx 8649 12 etc etc FW cord-010092-uftc8inx 8649 13 . . . cord-010092-uftc8inx 8650 1 were be VBD cord-010092-uftc8inx 8650 2 more more RBR cord-010092-uftc8inx 8650 3 common common JJ cord-010092-uftc8inx 8650 4 in in IN cord-010092-uftc8inx 8650 5 O o NN cord-010092-uftc8inx 8650 6 group group NN cord-010092-uftc8inx 8650 7 of of IN cord-010092-uftc8inx 8650 8 patients patient NNS cord-010092-uftc8inx 8650 9 while while IN cord-010092-uftc8inx 8650 10 in in IN cord-010092-uftc8inx 8650 11 our -PRON- PRP$ cord-010092-uftc8inx 8650 12 population population NN cord-010092-uftc8inx 8650 13 frequency frequency NN cord-010092-uftc8inx 8650 14 of of IN cord-010092-uftc8inx 8650 15 B B NNP cord-010092-uftc8inx 8650 16 blood blood NN cord-010092-uftc8inx 8650 17 group group NN cord-010092-uftc8inx 8650 18 antigen antigen NN cord-010092-uftc8inx 8650 19 ( ( -LRB- cord-010092-uftc8inx 8650 20 38.2 38.2 CD cord-010092-uftc8inx 8650 21 % % NN cord-010092-uftc8inx 8650 22 ) ) -RRB- cord-010092-uftc8inx 8650 23 is be VBZ cord-010092-uftc8inx 8650 24 more more RBR cord-010092-uftc8inx 8650 25 common common JJ cord-010092-uftc8inx 8650 26 as as IN cord-010092-uftc8inx 8650 27 compared compare VBN cord-010092-uftc8inx 8650 28 to to IN cord-010092-uftc8inx 8650 29 O o NN cord-010092-uftc8inx 8650 30 blood blood NN cord-010092-uftc8inx 8650 31 group(33.4 group(33.4 NNP cord-010092-uftc8inx 8650 32 % % NN cord-010092-uftc8inx 8650 33 ) ) -RRB- cord-010092-uftc8inx 8650 34 . . . cord-010092-uftc8inx 8651 1 Background background NN cord-010092-uftc8inx 8651 2 : : : cord-010092-uftc8inx 8652 1 RHD RHD NNP cord-010092-uftc8inx 8652 2 and and CC cord-010092-uftc8inx 8652 3 RHCE RHCE NNP cord-010092-uftc8inx 8652 4 represent represent VBP cord-010092-uftc8inx 8652 5 homologous homologous JJ cord-010092-uftc8inx 8652 6 genes gene NNS cord-010092-uftc8inx 8652 7 in in IN cord-010092-uftc8inx 8652 8 head head NN cord-010092-uftc8inx 8652 9 - - HYPH cord-010092-uftc8inx 8652 10 to to IN cord-010092-uftc8inx 8652 11 - - HYPH cord-010092-uftc8inx 8652 12 head head NN cord-010092-uftc8inx 8652 13 position position NN cord-010092-uftc8inx 8652 14 on on IN cord-010092-uftc8inx 8652 15 chromosome chromosome NN cord-010092-uftc8inx 8652 16 1 1 CD cord-010092-uftc8inx 8652 17 ( ( -LRB- cord-010092-uftc8inx 8652 18 chr1 chr1 NNS cord-010092-uftc8inx 8652 19 , , , cord-010092-uftc8inx 8652 20 p36.11 p36.11 JJ cord-010092-uftc8inx 8652 21 ) ) -RRB- cord-010092-uftc8inx 8652 22 . . . cord-010092-uftc8inx 8653 1 They -PRON- PRP cord-010092-uftc8inx 8653 2 encode encode VBP cord-010092-uftc8inx 8653 3 for for IN cord-010092-uftc8inx 8653 4 the the DT cord-010092-uftc8inx 8653 5 proteins protein NNS cord-010092-uftc8inx 8653 6 RhD RhD NNP cord-010092-uftc8inx 8653 7 resp resp NNP cord-010092-uftc8inx 8653 8 . . . cord-010092-uftc8inx 8654 1 RhCE RhCE NNP cord-010092-uftc8inx 8654 2 which which WDT cord-010092-uftc8inx 8654 3 compose compose VBP cord-010092-uftc8inx 8654 4 together together RB cord-010092-uftc8inx 8654 5 with with IN cord-010092-uftc8inx 8654 6 Rhesus Rhesus NNP cord-010092-uftc8inx 8654 7 associated associate VBD cord-010092-uftc8inx 8654 8 glycoprotein glycoprotein NN cord-010092-uftc8inx 8654 9 ( ( -LRB- cord-010092-uftc8inx 8654 10 RhAG RhAG NNP cord-010092-uftc8inx 8654 11 ) ) -RRB- cord-010092-uftc8inx 8654 12 , , , cord-010092-uftc8inx 8654 13 Band Band NNP cord-010092-uftc8inx 8654 14 3 3 CD cord-010092-uftc8inx 8654 15 and and CC cord-010092-uftc8inx 8654 16 ankyrin ankyrin VB cord-010092-uftc8inx 8654 17 the the DT cord-010092-uftc8inx 8654 18 ankyrin ankyrin NN cord-010092-uftc8inx 8654 19 complex complex NN cord-010092-uftc8inx 8654 20 ( ( -LRB- cord-010092-uftc8inx 8654 21 AC ac NN cord-010092-uftc8inx 8654 22 ) ) -RRB- cord-010092-uftc8inx 8654 23 linking link VBG cord-010092-uftc8inx 8654 24 the the DT cord-010092-uftc8inx 8654 25 red red JJ cord-010092-uftc8inx 8654 26 blood blood NN cord-010092-uftc8inx 8654 27 cell cell NN cord-010092-uftc8inx 8654 28 ( ( -LRB- cord-010092-uftc8inx 8654 29 RBC RBC NNP cord-010092-uftc8inx 8654 30 ) ) -RRB- cord-010092-uftc8inx 8654 31 membrane membrane NN cord-010092-uftc8inx 8654 32 to to IN cord-010092-uftc8inx 8654 33 aspectrin aspectrin NNP cord-010092-uftc8inx 8654 34 of of IN cord-010092-uftc8inx 8654 35 RBC RBC NNP cord-010092-uftc8inx 8654 36 cytoskeleton cytoskeleton NNP cord-010092-uftc8inx 8655 1 ( ( -LRB- cord-010092-uftc8inx 8655 2 S.E. S.E. NNP cord-010092-uftc8inx 8655 3 Lux Lux NNP cord-010092-uftc8inx 8655 4 , , , cord-010092-uftc8inx 8655 5 BLOOD blood NN cord-010092-uftc8inx 8655 6 , , , cord-010092-uftc8inx 8655 7 2016 2016 CD cord-010092-uftc8inx 8655 8 ) ) -RRB- cord-010092-uftc8inx 8655 9 . . . cord-010092-uftc8inx 8656 1 Cooperatively cooperatively RB cord-010092-uftc8inx 8656 2 , , , cord-010092-uftc8inx 8656 3 the the DT cord-010092-uftc8inx 8656 4 proteins protein NNS cord-010092-uftc8inx 8656 5 of of IN cord-010092-uftc8inx 8656 6 AC AC NNP cord-010092-uftc8inx 8656 7 are be VBP cord-010092-uftc8inx 8656 8 important important JJ cord-010092-uftc8inx 8656 9 for for IN cord-010092-uftc8inx 8656 10 maturation maturation NN cord-010092-uftc8inx 8656 11 and and CC cord-010092-uftc8inx 8656 12 physiologic physiologic JJ cord-010092-uftc8inx 8656 13 properties property NNS cord-010092-uftc8inx 8656 14 of of IN cord-010092-uftc8inx 8656 15 RBCs rbc NNS cord-010092-uftc8inx 8656 16 . . . cord-010092-uftc8inx 8657 1 Many many JJ cord-010092-uftc8inx 8657 2 proteins protein NNS cord-010092-uftc8inx 8657 3 of of IN cord-010092-uftc8inx 8657 4 the the DT cord-010092-uftc8inx 8657 5 RBC RBC NNP cord-010092-uftc8inx 8657 6 membrane membrane NN cord-010092-uftc8inx 8657 7 express express VB cord-010092-uftc8inx 8657 8 blood blood NN cord-010092-uftc8inx 8657 9 group group NN cord-010092-uftc8inx 8657 10 antigens antigen NNS cord-010092-uftc8inx 8657 11 on on IN cord-010092-uftc8inx 8657 12 their -PRON- PRP$ cord-010092-uftc8inx 8657 13 extracellular extracellular JJ cord-010092-uftc8inx 8657 14 surface surface NN cord-010092-uftc8inx 8657 15 and and CC cord-010092-uftc8inx 8657 16 are be VBP cord-010092-uftc8inx 8657 17 therefore therefore RB cord-010092-uftc8inx 8657 18 of of IN cord-010092-uftc8inx 8657 19 concern concern NN cord-010092-uftc8inx 8657 20 in in IN cord-010092-uftc8inx 8657 21 transfusion transfusion NN cord-010092-uftc8inx 8657 22 medicine medicine NN cord-010092-uftc8inx 8657 23 . . . cord-010092-uftc8inx 8658 1 Cepellini Cepellini NNP cord-010092-uftc8inx 8658 2 et et NNP cord-010092-uftc8inx 8658 3 al al NNP cord-010092-uftc8inx 8658 4 . . . cord-010092-uftc8inx 8659 1 described describe VBN cord-010092-uftc8inx 8659 2 weakened weakened JJ cord-010092-uftc8inx 8659 3 hemagglutination hemagglutination NN cord-010092-uftc8inx 8659 4 reactions reaction NNS cord-010092-uftc8inx 8659 5 of of IN cord-010092-uftc8inx 8659 6 RHD+ RHD+ NNP cord-010092-uftc8inx 8659 7 RBCs rbc NNS cord-010092-uftc8inx 8659 8 in in IN cord-010092-uftc8inx 8659 9 the the DT cord-010092-uftc8inx 8659 10 presence presence NN cord-010092-uftc8inx 8659 11 of of IN cord-010092-uftc8inx 8659 12 an an DT cord-010092-uftc8inx 8659 13 RhC+ RhC+ NNP cord-010092-uftc8inx 8659 14 antigen antigen NN cord-010092-uftc8inx 8659 15 ( ( -LRB- cord-010092-uftc8inx 8659 16 Cepellini Cepellini NNP cord-010092-uftc8inx 8659 17 et et NNP cord-010092-uftc8inx 8659 18 al al NNP cord-010092-uftc8inx 8659 19 , , , cord-010092-uftc8inx 8659 20 PNAS PNAS NNP cord-010092-uftc8inx 8659 21 , , , cord-010092-uftc8inx 8659 22 1955 1955 CD cord-010092-uftc8inx 8659 23 ) ) -RRB- cord-010092-uftc8inx 8659 24 . . . cord-010092-uftc8inx 8660 1 We -PRON- PRP cord-010092-uftc8inx 8660 2 attempted attempt VBD cord-010092-uftc8inx 8660 3 to to TO cord-010092-uftc8inx 8660 4 further further RB cord-010092-uftc8inx 8660 5 elucidate elucidate VB cord-010092-uftc8inx 8660 6 the the DT cord-010092-uftc8inx 8660 7 expression expression NN cord-010092-uftc8inx 8660 8 of of IN cord-010092-uftc8inx 8660 9 RhD RhD NNP cord-010092-uftc8inx 8660 10 / / SYM cord-010092-uftc8inx 8660 11 RhAG rhag NN cord-010092-uftc8inx 8660 12 proteins protein NNS cord-010092-uftc8inx 8660 13 in in IN cord-010092-uftc8inx 8660 14 various various JJ cord-010092-uftc8inx 8660 15 RhCE RhCE NNP cord-010092-uftc8inx 8660 16 / / SYM cord-010092-uftc8inx 8660 17 RHCE RHCE NNP cord-010092-uftc8inx 8660 18 pheno-/genotypes pheno-/genotypes NNP cord-010092-uftc8inx 8660 19 using use VBG cord-010092-uftc8inx 8660 20 a a DT cord-010092-uftc8inx 8660 21 sophisticated sophisticated JJ cord-010092-uftc8inx 8660 22 flow flow NN cord-010092-uftc8inx 8660 23 cytometry cytometry NN cord-010092-uftc8inx 8660 24 approach approach NN cord-010092-uftc8inx 8660 25 . . . cord-010092-uftc8inx 8661 1 Aims aim VBZ cord-010092-uftc8inx 8661 2 : : : cord-010092-uftc8inx 8662 1 In in IN cord-010092-uftc8inx 8662 2 this this DT cord-010092-uftc8inx 8662 3 study study NN cord-010092-uftc8inx 8662 4 , , , cord-010092-uftc8inx 8662 5 we -PRON- PRP cord-010092-uftc8inx 8662 6 investigated investigate VBD cord-010092-uftc8inx 8662 7 a a DT cord-010092-uftc8inx 8662 8 flow flow NN cord-010092-uftc8inx 8662 9 cytometric cytometric NN cord-010092-uftc8inx 8662 10 method method NN cord-010092-uftc8inx 8662 11 for for IN cord-010092-uftc8inx 8662 12 measurement measurement NN cord-010092-uftc8inx 8662 13 of of IN cord-010092-uftc8inx 8662 14 the the DT cord-010092-uftc8inx 8662 15 antigen antigen NN cord-010092-uftc8inx 8662 16 - - HYPH cord-010092-uftc8inx 8662 17 density density NN cord-010092-uftc8inx 8662 18 of of IN cord-010092-uftc8inx 8662 19 various various JJ cord-010092-uftc8inx 8662 20 RHCE RHCE NNP cord-010092-uftc8inx 8662 21 - - HYPH cord-010092-uftc8inx 8662 22 phenotypes phenotype NNS cord-010092-uftc8inx 8662 23 . . . cord-010092-uftc8inx 8663 1 Methods method NNS cord-010092-uftc8inx 8663 2 : : : cord-010092-uftc8inx 8663 3 Analysis Analysis NNP cord-010092-uftc8inx 8663 4 was be VBD cord-010092-uftc8inx 8663 5 performed perform VBN cord-010092-uftc8inx 8663 6 on on IN cord-010092-uftc8inx 8663 7 a a DT cord-010092-uftc8inx 8663 8 flow flow NN cord-010092-uftc8inx 8663 9 cytometer cytometer NN cord-010092-uftc8inx 8663 10 ( ( -LRB- cord-010092-uftc8inx 8663 11 FACSCanto facscanto IN cord-010092-uftc8inx 8663 12 II II NNP cord-010092-uftc8inx 8663 13 , , , cord-010092-uftc8inx 8663 14 Becton Becton NNP cord-010092-uftc8inx 8663 15 Dickinson Dickinson NNP cord-010092-uftc8inx 8663 16 ( ( -LRB- cord-010092-uftc8inx 8663 17 BD BD NNP cord-010092-uftc8inx 8663 18 ) ) -RRB- cord-010092-uftc8inx 8663 19 ) ) -RRB- cord-010092-uftc8inx 8663 20 using use VBG cord-010092-uftc8inx 8663 21 BD BD NNP cord-010092-uftc8inx 8663 22 FACSDiva facsdiva NN cord-010092-uftc8inx 8663 23 software software NN cord-010092-uftc8inx 8663 24 and and CC cord-010092-uftc8inx 8663 25 identical identical JJ cord-010092-uftc8inx 8663 26 instrument instrument NN cord-010092-uftc8inx 8663 27 settings setting NNS cord-010092-uftc8inx 8663 28 for for IN cord-010092-uftc8inx 8663 29 all all DT cord-010092-uftc8inx 8663 30 samples sample NNS cord-010092-uftc8inx 8663 31 . . . cord-010092-uftc8inx 8664 1 Optimized optimize VBN cord-010092-uftc8inx 8664 2 number number NN cord-010092-uftc8inx 8664 3 of of IN cord-010092-uftc8inx 8664 4 RBCs rbc NNS cord-010092-uftc8inx 8664 5 was be VBD cord-010092-uftc8inx 8664 6 incubated incubate VBN cord-010092-uftc8inx 8664 7 with with IN cord-010092-uftc8inx 8664 8 saturating saturate VBG cord-010092-uftc8inx 8664 9 concentration concentration NN cord-010092-uftc8inx 8664 10 of of IN cord-010092-uftc8inx 8664 11 PE pe NN cord-010092-uftc8inx 8664 12 - - HYPH cord-010092-uftc8inx 8664 13 conjugated conjugate VBN cord-010092-uftc8inx 8664 14 anti anti JJ cord-010092-uftc8inx 8664 15 - - JJ cord-010092-uftc8inx 8664 16 RhD rhd JJ cord-010092-uftc8inx 8664 17 antibodies antibody NNS cord-010092-uftc8inx 8664 18 BRAD-3 BRAD-3 NNP cord-010092-uftc8inx 8664 19 / / SYM cord-010092-uftc8inx 8664 20 BRAD-5 BRAD-5 NNP cord-010092-uftc8inx 8664 21 / / SYM cord-010092-uftc8inx 8664 22 FOG-1 FOG-1 NNP cord-010092-uftc8inx 8664 23 ( ( -LRB- cord-010092-uftc8inx 8664 24 IBGRL IBGRL NNP cord-010092-uftc8inx 8664 25 , , , cord-010092-uftc8inx 8664 26 Bristol Bristol NNP cord-010092-uftc8inx 8664 27 , , , cord-010092-uftc8inx 8664 28 UK UK NNP cord-010092-uftc8inx 8664 29 ) ) -RRB- cord-010092-uftc8inx 8664 30 . . . cord-010092-uftc8inx 8665 1 Debris debris NN cord-010092-uftc8inx 8665 2 was be VBD cord-010092-uftc8inx 8665 3 excluded exclude VBN cord-010092-uftc8inx 8665 4 by by IN cord-010092-uftc8inx 8665 5 RBC RBC NNP cord-010092-uftc8inx 8665 6 gating gate VBG cord-010092-uftc8inx 8665 7 in in IN cord-010092-uftc8inx 8665 8 FSC FSC NNP cord-010092-uftc8inx 8665 9 / / SYM cord-010092-uftc8inx 8665 10 SSC SSC NNP cord-010092-uftc8inx 8665 11 plot plot NN cord-010092-uftc8inx 8665 12 . . . cord-010092-uftc8inx 8666 1 QuantiBRITE QuantiBRITE NNP cord-010092-uftc8inx 8666 2 - - HYPH cord-010092-uftc8inx 8666 3 PE PE NNP cord-010092-uftc8inx 8666 4 beats beat NNS cord-010092-uftc8inx 8666 5 ( ( -LRB- cord-010092-uftc8inx 8666 6 BD BD NNP cord-010092-uftc8inx 8666 7 ) ) -RRB- cord-010092-uftc8inx 8666 8 were be VBD cord-010092-uftc8inx 8666 9 applied apply VBN cord-010092-uftc8inx 8666 10 according accord VBG cord-010092-uftc8inx 8666 11 to to IN cord-010092-uftc8inx 8666 12 manufacturer manufacturer NN cord-010092-uftc8inx 8666 13 's 's POS cord-010092-uftc8inx 8666 14 instruction instruction NN cord-010092-uftc8inx 8666 15 to to TO cord-010092-uftc8inx 8666 16 quantify quantify VB cord-010092-uftc8inx 8666 17 the the DT cord-010092-uftc8inx 8666 18 relative relative JJ cord-010092-uftc8inx 8666 19 expression expression NN cord-010092-uftc8inx 8666 20 of of IN cord-010092-uftc8inx 8666 21 RhD rhd NN cord-010092-uftc8inx 8666 22 epitopes epitopes NNP cord-010092-uftc8inx 8666 23 . . . cord-010092-uftc8inx 8667 1 In in IN cord-010092-uftc8inx 8667 2 addition addition NN cord-010092-uftc8inx 8667 3 a a DT cord-010092-uftc8inx 8667 4 representative representative JJ cord-010092-uftc8inx 8667 5 number number NN cord-010092-uftc8inx 8667 6 of of IN cord-010092-uftc8inx 8667 7 samples sample NNS cord-010092-uftc8inx 8667 8 from from IN cord-010092-uftc8inx 8667 9 common common JJ cord-010092-uftc8inx 8667 10 phenotypes phenotype NNS cord-010092-uftc8inx 8667 11 were be VBD cord-010092-uftc8inx 8667 12 assessed assess VBN cord-010092-uftc8inx 8667 13 for for IN cord-010092-uftc8inx 8667 14 expression expression NN cord-010092-uftc8inx 8667 15 of of IN cord-010092-uftc8inx 8667 16 RhAG rhag NN cord-010092-uftc8inx 8667 17 using use VBG cord-010092-uftc8inx 8667 18 BRIC-69PE bric-69pe JJ cord-010092-uftc8inx 8667 19 ( ( -LRB- cord-010092-uftc8inx 8667 20 IBGRL IBGRL NNP cord-010092-uftc8inx 8667 21 ) ) -RRB- cord-010092-uftc8inx 8667 22 . . . cord-010092-uftc8inx 8668 1 Results result NNS cord-010092-uftc8inx 8668 2 : : : cord-010092-uftc8inx 8669 1 A a DT cord-010092-uftc8inx 8669 2 total total NN cord-010092-uftc8inx 8669 3 of of IN cord-010092-uftc8inx 8669 4 146 146 CD cord-010092-uftc8inx 8669 5 samples sample NNS cord-010092-uftc8inx 8669 6 from from IN cord-010092-uftc8inx 8669 7 healthy healthy JJ cord-010092-uftc8inx 8669 8 blood blood NN cord-010092-uftc8inx 8669 9 donors donor NNS cord-010092-uftc8inx 8669 10 with with IN cord-010092-uftc8inx 8669 11 serologically serologically RB cord-010092-uftc8inx 8669 12 defined define VBN cord-010092-uftc8inx 8669 13 RhCDE rhcde JJ cord-010092-uftc8inx 8669 14 phenotypes phenotype NNS cord-010092-uftc8inx 8669 15 were be VBD cord-010092-uftc8inx 8669 16 included include VBN cord-010092-uftc8inx 8669 17 into into IN cord-010092-uftc8inx 8669 18 this this DT cord-010092-uftc8inx 8669 19 study study NN cord-010092-uftc8inx 8669 20 ( ( -LRB- cord-010092-uftc8inx 8669 21 rr(21 rr(21 NNS cord-010092-uftc8inx 8669 22 ) ) -RRB- cord-010092-uftc8inx 8669 23 , , , cord-010092-uftc8inx 8669 24 R1r(20 R1r(20 NNPS cord-010092-uftc8inx 8669 25 ) ) -RRB- cord-010092-uftc8inx 8669 26 , , , cord-010092-uftc8inx 8669 27 R1R1(23 R1R1(23 NNS cord-010092-uftc8inx 8669 28 ) ) -RRB- cord-010092-uftc8inx 8669 29 , , , cord-010092-uftc8inx 8669 30 R2r(18 R2r(18 NNP cord-010092-uftc8inx 8669 31 ) ) -RRB- cord-010092-uftc8inx 8669 32 , , , cord-010092-uftc8inx 8669 33 R0r(15 R0r(15 NNP cord-010092-uftc8inx 8669 34 ) ) -RRB- cord-010092-uftc8inx 8669 35 , , , cord-010092-uftc8inx 8669 36 R1R2(27 r1r2(27 NN cord-010092-uftc8inx 8669 37 ) ) -RRB- cord-010092-uftc8inx 8669 38 , , , cord-010092-uftc8inx 8669 39 R2R2 R2R2 NNP cord-010092-uftc8inx 8669 40 ( ( -LRB- cord-010092-uftc8inx 8669 41 22 22 CD cord-010092-uftc8inx 8669 42 ) ) -RRB- cord-010092-uftc8inx 8669 43 ) ) -RRB- cord-010092-uftc8inx 8669 44 . . . cord-010092-uftc8inx 8670 1 Variant variant JJ cord-010092-uftc8inx 8670 2 expression expression NN cord-010092-uftc8inx 8670 3 of of IN cord-010092-uftc8inx 8670 4 RhD rhd NN cord-010092-uftc8inx 8670 5 by by IN cord-010092-uftc8inx 8670 6 different different JJ cord-010092-uftc8inx 8670 7 RhCE rhce NN cord-010092-uftc8inx 8670 8 phenotypes phenotype NNS cord-010092-uftc8inx 8670 9 using use VBG cord-010092-uftc8inx 8670 10 BRAD-3-PE brad-3-pe NN cord-010092-uftc8inx 8670 11 was be VBD cord-010092-uftc8inx 8670 12 shown show VBN cord-010092-uftc8inx 8670 13 . . . cord-010092-uftc8inx 8671 1 RhD RhD NNP cord-010092-uftc8inx 8671 2 was be VBD cord-010092-uftc8inx 8671 3 weakly weakly RB cord-010092-uftc8inx 8671 4 expressed express VBN cord-010092-uftc8inx 8671 5 in in IN cord-010092-uftc8inx 8671 6 presence presence NN cord-010092-uftc8inx 8671 7 of of IN cord-010092-uftc8inx 8671 8 RhC rhc NN cord-010092-uftc8inx 8671 9 antigen antigen NNP cord-010092-uftc8inx 8671 10 ( ( -LRB- cord-010092-uftc8inx 8671 11 Cepellini Cepellini NNP cord-010092-uftc8inx 8671 12 effect effect NN cord-010092-uftc8inx 8671 13 ) ) -RRB- cord-010092-uftc8inx 8671 14 . . . cord-010092-uftc8inx 8672 1 Effect effect NN cord-010092-uftc8inx 8672 2 of of IN cord-010092-uftc8inx 8672 3 RHD RHD NNP cord-010092-uftc8inx 8672 4 gene gene NN cord-010092-uftc8inx 8672 5 dose dose NN cord-010092-uftc8inx 8672 6 on on IN cord-010092-uftc8inx 8672 7 RhD RhD NNP cord-010092-uftc8inx 8672 8 protein protein NN cord-010092-uftc8inx 8672 9 expression expression NN cord-010092-uftc8inx 8672 10 is be VBZ cord-010092-uftc8inx 8672 11 mitigated mitigate VBN cord-010092-uftc8inx 8672 12 by by IN cord-010092-uftc8inx 8672 13 RHC RHC NNP cord-010092-uftc8inx 8672 14 / / SYM cord-010092-uftc8inx 8672 15 c c NN cord-010092-uftc8inx 8672 16 genotypes genotype NNS cord-010092-uftc8inx 8672 17 . . . cord-010092-uftc8inx 8673 1 When when WRB cord-010092-uftc8inx 8673 2 only only RB cord-010092-uftc8inx 8673 3 samples sample NNS cord-010092-uftc8inx 8673 4 with with IN cord-010092-uftc8inx 8673 5 molecularly molecularly RB cord-010092-uftc8inx 8673 6 confirmed confirm VBN cord-010092-uftc8inx 8673 7 phenotypes phenotype NNS cord-010092-uftc8inx 8673 8 were be VBD cord-010092-uftc8inx 8673 9 assessed assess VBN cord-010092-uftc8inx 8673 10 , , , cord-010092-uftc8inx 8673 11 the the DT cord-010092-uftc8inx 8673 12 RHDCE RHDCE NNP cord-010092-uftc8inx 8673 13 genotype genotype NN cord-010092-uftc8inx 8673 14 predicts predict VBZ cord-010092-uftc8inx 8673 15 consistently consistently RB cord-010092-uftc8inx 8673 16 the the DT cord-010092-uftc8inx 8673 17 strength strength NN cord-010092-uftc8inx 8673 18 of of IN cord-010092-uftc8inx 8673 19 RhD RhD NNP cord-010092-uftc8inx 8673 20 protein protein NNP cord-010092-uftc8inx 8673 21 expression expression NN cord-010092-uftc8inx 8673 22 . . . cord-010092-uftc8inx 8674 1 Outlier outlier JJ cord-010092-uftc8inx 8674 2 samples sample NNS cord-010092-uftc8inx 8674 3 ( ( -LRB- cord-010092-uftc8inx 8674 4 3 3 CD cord-010092-uftc8inx 8674 5 ) ) -RRB- cord-010092-uftc8inx 8674 6 were be VBD cord-010092-uftc8inx 8674 7 retrospectively retrospectively RB cord-010092-uftc8inx 8674 8 genotyped genotype VBN cord-010092-uftc8inx 8674 9 and and CC cord-010092-uftc8inx 8674 10 revealed reveal VBD cord-010092-uftc8inx 8674 11 RHDCE RHDCE NNP cord-010092-uftc8inx 8674 12 genotypes genotype NNS cord-010092-uftc8inx 8674 13 as as IN cord-010092-uftc8inx 8674 14 expected expect VBN cord-010092-uftc8inx 8674 15 from from IN cord-010092-uftc8inx 8674 16 the the DT cord-010092-uftc8inx 8674 17 strength strength NN cord-010092-uftc8inx 8674 18 of of IN cord-010092-uftc8inx 8674 19 RhD RhD NNP cord-010092-uftc8inx 8674 20 expression expression NN cord-010092-uftc8inx 8674 21 falsifying falsify VBG cord-010092-uftc8inx 8674 22 serological serological JJ cord-010092-uftc8inx 8674 23 RhCDE rhcde JJ cord-010092-uftc8inx 8674 24 phenotypes phenotype NNS cord-010092-uftc8inx 8674 25 . . . cord-010092-uftc8inx 8675 1 In in IN cord-010092-uftc8inx 8675 2 contrast contrast NN cord-010092-uftc8inx 8675 3 , , , cord-010092-uftc8inx 8675 4 RHE RHE NNP cord-010092-uftc8inx 8675 5 / / SYM cord-010092-uftc8inx 8675 6 e e NN cord-010092-uftc8inx 8675 7 polymorphic polymorphic JJ cord-010092-uftc8inx 8675 8 site site NN cord-010092-uftc8inx 8675 9 does do VBZ cord-010092-uftc8inx 8675 10 not not RB cord-010092-uftc8inx 8675 11 correlate correlate VB cord-010092-uftc8inx 8675 12 with with IN cord-010092-uftc8inx 8675 13 RhD rhd NN cord-010092-uftc8inx 8675 14 expression expression NN cord-010092-uftc8inx 8675 15 . . . cord-010092-uftc8inx 8676 1 In in IN cord-010092-uftc8inx 8676 2 addition addition NN cord-010092-uftc8inx 8676 3 , , , cord-010092-uftc8inx 8676 4 RhAG rhag NN cord-010092-uftc8inx 8676 5 protein protein NN cord-010092-uftc8inx 8676 6 is be VBZ cord-010092-uftc8inx 8676 7 equally equally RB cord-010092-uftc8inx 8676 8 present present JJ cord-010092-uftc8inx 8676 9 across across IN cord-010092-uftc8inx 8676 10 all all DT cord-010092-uftc8inx 8676 11 RhCDE rhcde JJ cord-010092-uftc8inx 8676 12 phenotypes phenotype NNS cord-010092-uftc8inx 8676 13 . . . cord-010092-uftc8inx 8677 1 Similar similar JJ cord-010092-uftc8inx 8677 2 results result NNS cord-010092-uftc8inx 8677 3 were be VBD cord-010092-uftc8inx 8677 4 obtained obtain VBN cord-010092-uftc8inx 8677 5 by by IN cord-010092-uftc8inx 8677 6 using use VBG cord-010092-uftc8inx 8677 7 alternative alternative JJ cord-010092-uftc8inx 8677 8 anti anti JJ cord-010092-uftc8inx 8677 9 - - JJ cord-010092-uftc8inx 8677 10 D d JJ cord-010092-uftc8inx 8677 11 antibodies antibody NNS cord-010092-uftc8inx 8677 12 such such JJ cord-010092-uftc8inx 8677 13 as as IN cord-010092-uftc8inx 8677 14 BRAD-5-PE BRAD-5-PE NNP cord-010092-uftc8inx 8677 15 and and CC cord-010092-uftc8inx 8677 16 FOG-1-PE FOG-1-PE NNP cord-010092-uftc8inx 8677 17 , , , cord-010092-uftc8inx 8677 18 although although IN cord-010092-uftc8inx 8677 19 different different JJ cord-010092-uftc8inx 8677 20 antibody antibody NN cord-010092-uftc8inx 8677 21 's 's POS cord-010092-uftc8inx 8677 22 avidity avidity NN cord-010092-uftc8inx 8677 23 precludes preclude VBZ cord-010092-uftc8inx 8677 24 quantitative quantitative JJ cord-010092-uftc8inx 8677 25 comparison comparison NN cord-010092-uftc8inx 8677 26 of of IN cord-010092-uftc8inx 8677 27 antigen antigen NN cord-010092-uftc8inx 8677 28 expression expression NN cord-010092-uftc8inx 8677 29 on on IN cord-010092-uftc8inx 8677 30 RBCs rbc NNS cord-010092-uftc8inx 8677 31 . . . cord-010092-uftc8inx 8678 1 Summary Summary NNP cord-010092-uftc8inx 8678 2 / / SYM cord-010092-uftc8inx 8678 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 8678 4 : : : cord-010092-uftc8inx 8679 1 Sophisticated sophisticated JJ cord-010092-uftc8inx 8679 2 FACS FACS NNP cord-010092-uftc8inx 8679 3 methods method NNS cord-010092-uftc8inx 8679 4 reveal reveal VBP cord-010092-uftc8inx 8679 5 different different JJ cord-010092-uftc8inx 8679 6 expression expression NN cord-010092-uftc8inx 8679 7 of of IN cord-010092-uftc8inx 8679 8 RhD rhd NN cord-010092-uftc8inx 8679 9 on on IN cord-010092-uftc8inx 8679 10 RBCs rbc NNS cord-010092-uftc8inx 8679 11 according accord VBG cord-010092-uftc8inx 8679 12 to to IN cord-010092-uftc8inx 8679 13 RhCE RhCE NNP cord-010092-uftc8inx 8679 14 / / SYM cord-010092-uftc8inx 8679 15 RHCE RHCE NNP cord-010092-uftc8inx 8679 16 phenotype phenotype NN cord-010092-uftc8inx 8679 17 / / SYM cord-010092-uftc8inx 8679 18 genotype genotype NN cord-010092-uftc8inx 8679 19 . . . cord-010092-uftc8inx 8680 1 RHC RHC NNP cord-010092-uftc8inx 8680 2 / / SYM cord-010092-uftc8inx 8680 3 c c NN cord-010092-uftc8inx 8680 4 polymorphic polymorphic JJ cord-010092-uftc8inx 8680 5 sites site NNS cord-010092-uftc8inx 8680 6 ( ( -LRB- cord-010092-uftc8inx 8680 7 c.48 c.48 JJ cord-010092-uftc8inx 8680 8 G g NN cord-010092-uftc8inx 8680 9 > > XX cord-010092-uftc8inx 8681 1 C C NNP cord-010092-uftc8inx 8681 2 , , , cord-010092-uftc8inx 8681 3 c.201A c.201A NNP cord-010092-uftc8inx 8681 4 > > XX cord-010092-uftc8inx 8681 5 G G NNP cord-010092-uftc8inx 8681 6 , , , cord-010092-uftc8inx 8681 7 c.203A c.203A NNP cord-010092-uftc8inx 8682 1 > > XX cord-010092-uftc8inx 8683 1 G g NN cord-010092-uftc8inx 8683 2 of of IN cord-010092-uftc8inx 8683 3 exon exon NN cord-010092-uftc8inx 8683 4 1 1 CD cord-010092-uftc8inx 8683 5 , , , cord-010092-uftc8inx 8683 6 exon exon NN cord-010092-uftc8inx 8683 7 2 2 CD cord-010092-uftc8inx 8683 8 resp resp NN cord-010092-uftc8inx 8683 9 . . . cord-010092-uftc8inx 8684 1 and and CC cord-010092-uftc8inx 8684 2 intron intron NN cord-010092-uftc8inx 8684 3 2 2 CD cord-010092-uftc8inx 8684 4 ) ) -RRB- cord-010092-uftc8inx 8684 5 are be VBP cord-010092-uftc8inx 8684 6 in in IN cord-010092-uftc8inx 8684 7 linkage linkage NN cord-010092-uftc8inx 8684 8 with with IN cord-010092-uftc8inx 8684 9 RhD rhd NN cord-010092-uftc8inx 8684 10 expression expression NN cord-010092-uftc8inx 8684 11 , , , cord-010092-uftc8inx 8684 12 confirming confirm VBG cord-010092-uftc8inx 8684 13 the the DT cord-010092-uftc8inx 8684 14 observation observation NN cord-010092-uftc8inx 8684 15 by by IN cord-010092-uftc8inx 8684 16 Cepellini Cepellini NNP cord-010092-uftc8inx 8684 17 et et NNP cord-010092-uftc8inx 8684 18 al al NNP cord-010092-uftc8inx 8684 19 . . . cord-010092-uftc8inx 8685 1 In in IN cord-010092-uftc8inx 8685 2 contrast contrast NN cord-010092-uftc8inx 8685 3 , , , cord-010092-uftc8inx 8685 4 RHE RHE NNP cord-010092-uftc8inx 8685 5 / / SYM cord-010092-uftc8inx 8685 6 e e NN cord-010092-uftc8inx 8685 7 ( ( -LRB- cord-010092-uftc8inx 8685 8 c.676C c.676C NNP cord-010092-uftc8inx 8686 1 > > XX cord-010092-uftc8inx 8686 2 G G NNP cord-010092-uftc8inx 8686 3 , , , cord-010092-uftc8inx 8686 4 exon exon NN cord-010092-uftc8inx 8686 5 5 5 CD cord-010092-uftc8inx 8686 6 ) ) -RRB- cord-010092-uftc8inx 8686 7 is be VBZ cord-010092-uftc8inx 8686 8 not not RB cord-010092-uftc8inx 8686 9 in in IN cord-010092-uftc8inx 8686 10 linkage linkage NN cord-010092-uftc8inx 8686 11 with with IN cord-010092-uftc8inx 8686 12 RhD rhd NN cord-010092-uftc8inx 8686 13 expression expression NN cord-010092-uftc8inx 8686 14 . . . cord-010092-uftc8inx 8687 1 Based base VBN cord-010092-uftc8inx 8687 2 on on IN cord-010092-uftc8inx 8687 3 epigenomic epigenomic JJ cord-010092-uftc8inx 8687 4 signature signature NN cord-010092-uftc8inx 8687 5 it -PRON- PRP cord-010092-uftc8inx 8687 6 is be VBZ cord-010092-uftc8inx 8687 7 conceivable conceivable JJ cord-010092-uftc8inx 8687 8 that that IN cord-010092-uftc8inx 8687 9 altered altered JJ cord-010092-uftc8inx 8687 10 transcription transcription NN cord-010092-uftc8inx 8687 11 factor factor NN cord-010092-uftc8inx 8687 12 binding bind VBG cord-010092-uftc8inx 8687 13 sites site NNS cord-010092-uftc8inx 8687 14 ( ( -LRB- cord-010092-uftc8inx 8687 15 TBS TBS NNP cord-010092-uftc8inx 8687 16 ) ) -RRB- cord-010092-uftc8inx 8687 17 of of IN cord-010092-uftc8inx 8687 18 RHD RHD NNP cord-010092-uftc8inx 8687 19 mirrored mirror VBN cord-010092-uftc8inx 8687 20 by by IN cord-010092-uftc8inx 8687 21 homologous homologous JJ cord-010092-uftc8inx 8687 22 RHC RHC NNP cord-010092-uftc8inx 8687 23 / / SYM cord-010092-uftc8inx 8687 24 c c NN cord-010092-uftc8inx 8687 25 may may MD cord-010092-uftc8inx 8687 26 cause cause VB cord-010092-uftc8inx 8687 27 variant variant JJ cord-010092-uftc8inx 8687 28 RhD rhd NN cord-010092-uftc8inx 8687 29 expression expression NN cord-010092-uftc8inx 8687 30 . . . cord-010092-uftc8inx 8688 1 RHE RHE NNP cord-010092-uftc8inx 8688 2 / / SYM cord-010092-uftc8inx 8688 3 e e NN cord-010092-uftc8inx 8688 4 SNP SNP NNP cord-010092-uftc8inx 8688 5 mirroring mirror VBG cord-010092-uftc8inx 8688 6 the the DT cord-010092-uftc8inx 8688 7 homologous homologous JJ cord-010092-uftc8inx 8688 8 sequence sequence NN cord-010092-uftc8inx 8688 9 of of IN cord-010092-uftc8inx 8688 10 RHD RHD NNP cord-010092-uftc8inx 8688 11 in in IN cord-010092-uftc8inx 8688 12 exon exon NN cord-010092-uftc8inx 8688 13 5 5 CD cord-010092-uftc8inx 8688 14 is be VBZ cord-010092-uftc8inx 8688 15 not not RB cord-010092-uftc8inx 8688 16 recognised recognise VBN cord-010092-uftc8inx 8688 17 as as IN cord-010092-uftc8inx 8688 18 TBS TBS NNP cord-010092-uftc8inx 8688 19 . . . cord-010092-uftc8inx 8689 1 In in IN cord-010092-uftc8inx 8689 2 addition addition NN cord-010092-uftc8inx 8689 3 , , , cord-010092-uftc8inx 8689 4 although although IN cord-010092-uftc8inx 8689 5 AC AC NNP cord-010092-uftc8inx 8689 6 comprises comprise VBZ cord-010092-uftc8inx 8689 7 all all DT cord-010092-uftc8inx 8689 8 three three CD cord-010092-uftc8inx 8689 9 Rh Rh NNP cord-010092-uftc8inx 8689 10 proteins protein NNS cord-010092-uftc8inx 8689 11 ( ( -LRB- cord-010092-uftc8inx 8689 12 RhD RhD NNP cord-010092-uftc8inx 8689 13 , , , cord-010092-uftc8inx 8689 14 RhCE RhCE NNP cord-010092-uftc8inx 8689 15 , , , cord-010092-uftc8inx 8689 16 RhAG RhAG NNP cord-010092-uftc8inx 8689 17 ) ) -RRB- cord-010092-uftc8inx 8689 18 , , , cord-010092-uftc8inx 8689 19 their -PRON- PRP$ cord-010092-uftc8inx 8689 20 transcriptional transcriptional JJ cord-010092-uftc8inx 8689 21 regulations regulation NNS cord-010092-uftc8inx 8689 22 seem seem VBP cord-010092-uftc8inx 8689 23 to to TO cord-010092-uftc8inx 8689 24 be be VB cord-010092-uftc8inx 8689 25 distinct distinct JJ cord-010092-uftc8inx 8689 26 . . . cord-010092-uftc8inx 8690 1 Red Red NNP cord-010092-uftc8inx 8690 2 Cell Cell NNP cord-010092-uftc8inx 8690 3 Reference Reference NNP cord-010092-uftc8inx 8690 4 Laboratory Laboratory NNP cord-010092-uftc8inx 8690 5 , , , cord-010092-uftc8inx 8690 6 Australian Australian NNP cord-010092-uftc8inx 8690 7 Red Red NNP cord-010092-uftc8inx 8690 8 Cross Cross NNP cord-010092-uftc8inx 8690 9 Blood Blood NNP cord-010092-uftc8inx 8690 10 Service Service NNP cord-010092-uftc8inx 8690 11 , , , cord-010092-uftc8inx 8690 12 Perth Perth NNP cord-010092-uftc8inx 8691 1 , , , cord-010092-uftc8inx 8691 2 Australia Australia NNP cord-010092-uftc8inx 8691 3 Background Background NNP cord-010092-uftc8inx 8691 4 : : : cord-010092-uftc8inx 8692 1 The the DT cord-010092-uftc8inx 8692 2 Rh26 Rh26 NNP cord-010092-uftc8inx 8692 3 antigen antigen NN cord-010092-uftc8inx 8692 4 was be VBD cord-010092-uftc8inx 8692 5 first first RB cord-010092-uftc8inx 8692 6 described describe VBN cord-010092-uftc8inx 8692 7 when when WRB cord-010092-uftc8inx 8692 8 an an DT cord-010092-uftc8inx 8692 9 antisera antisera NN cord-010092-uftc8inx 8692 10 thought think VBD cord-010092-uftc8inx 8692 11 to to TO cord-010092-uftc8inx 8692 12 contain contain VB cord-010092-uftc8inx 8692 13 a a DT cord-010092-uftc8inx 8692 14 potent potent JJ cord-010092-uftc8inx 8692 15 anti anti JJ cord-010092-uftc8inx 8692 16 - - NN cord-010092-uftc8inx 8692 17 c c NN cord-010092-uftc8inx 8692 18 did do VBD cord-010092-uftc8inx 8692 19 not not RB cord-010092-uftc8inx 8692 20 react react VB cord-010092-uftc8inx 8692 21 with with IN cord-010092-uftc8inx 8692 22 all all DT cord-010092-uftc8inx 8692 23 c+ c+ NNP cord-010092-uftc8inx 8692 24 cells cell NNS cord-010092-uftc8inx 8692 25 . . . cord-010092-uftc8inx 8693 1 These these DT cord-010092-uftc8inx 8693 2 non non AFX cord-010092-uftc8inx 8693 3 - - JJ cord-010092-uftc8inx 8693 4 reacting reacting JJ cord-010092-uftc8inx 8693 5 c+ c+ CD cord-010092-uftc8inx 8693 6 cells cell NNS cord-010092-uftc8inx 8693 7 were be VBD cord-010092-uftc8inx 8693 8 classified classify VBN cord-010092-uftc8inx 8693 9 as as IN cord-010092-uftc8inx 8693 10 c+ c+ NNP cord-010092-uftc8inx 8693 11 , , , cord-010092-uftc8inx 8693 12 Rh:-26 Rh:-26 NNP cord-010092-uftc8inx 8693 13 , , , cord-010092-uftc8inx 8693 14 and and CC cord-010092-uftc8inx 8693 15 the the DT cord-010092-uftc8inx 8693 16 antibody antibody NN cord-010092-uftc8inx 8693 17 specificity specificity NN cord-010092-uftc8inx 8693 18 anti anti JJ cord-010092-uftc8inx 8693 19 - - JJ cord-010092-uftc8inx 8693 20 Rh26 rh26 JJ cord-010092-uftc8inx 8693 21 . . . cord-010092-uftc8inx 8694 1 Most Most JJS cord-010092-uftc8inx 8694 2 polyclonal polyclonal JJ cord-010092-uftc8inx 8694 3 anti anti NN cord-010092-uftc8inx 8694 4 - - NN cord-010092-uftc8inx 8694 5 c c JJ cord-010092-uftc8inx 8694 6 contain contain VBP cord-010092-uftc8inx 8694 7 anti anti NN cord-010092-uftc8inx 8694 8 - - NN cord-010092-uftc8inx 8694 9 c c JJ cord-010092-uftc8inx 8694 10 and and CC cord-010092-uftc8inx 8694 11 anti anti JJ cord-010092-uftc8inx 8694 12 - - JJ cord-010092-uftc8inx 8694 13 Rh26 rh26 JJ cord-010092-uftc8inx 8694 14 . . . cord-010092-uftc8inx 8695 1 Previous previous JJ cord-010092-uftc8inx 8695 2 studies study NNS cord-010092-uftc8inx 8695 3 have have VBP cord-010092-uftc8inx 8695 4 shown show VBN cord-010092-uftc8inx 8695 5 2 2 CD cord-010092-uftc8inx 8695 6 of of IN cord-010092-uftc8inx 8695 7 10 10 CD cord-010092-uftc8inx 8695 8 monoclonal monoclonal JJ cord-010092-uftc8inx 8695 9 anti anti JJ cord-010092-uftc8inx 8695 10 - - JJ cord-010092-uftc8inx 8695 11 c c JJ cord-010092-uftc8inx 8695 12 reagents reagent NNS cord-010092-uftc8inx 8695 13 are be VBP cord-010092-uftc8inx 8695 14 actually actually RB cord-010092-uftc8inx 8695 15 anti anti JJ cord-010092-uftc8inx 8695 16 - - JJ cord-010092-uftc8inx 8695 17 Rh26 rh26 JJ cord-010092-uftc8inx 8695 18 . . . cord-010092-uftc8inx 8696 1 These these DT cord-010092-uftc8inx 8696 2 reagents reagent NNS cord-010092-uftc8inx 8696 3 will will MD cord-010092-uftc8inx 8696 4 not not RB cord-010092-uftc8inx 8696 5 detect detect VB cord-010092-uftc8inx 8696 6 the the DT cord-010092-uftc8inx 8696 7 c c NN cord-010092-uftc8inx 8696 8 antigen antigen NN cord-010092-uftc8inx 8696 9 where where WRB cord-010092-uftc8inx 8696 10 the the DT cord-010092-uftc8inx 8696 11 red red JJ cord-010092-uftc8inx 8696 12 cells cell NNS cord-010092-uftc8inx 8696 13 are be VBP cord-010092-uftc8inx 8696 14 Rh:-26 Rh:-26 NNP cord-010092-uftc8inx 8696 15 . . . cord-010092-uftc8inx 8697 1 Aims aim VBZ cord-010092-uftc8inx 8697 2 : : : cord-010092-uftc8inx 8698 1 The the DT cord-010092-uftc8inx 8698 2 Australian australian JJ cord-010092-uftc8inx 8698 3 Red Red NNP cord-010092-uftc8inx 8698 4 Cross Cross NNP cord-010092-uftc8inx 8698 5 Blood Blood NNP cord-010092-uftc8inx 8698 6 Service Service NNP cord-010092-uftc8inx 8698 7 investigated investigate VBD cord-010092-uftc8inx 8698 8 a a DT cord-010092-uftc8inx 8698 9 phenotype phenotype NN cord-010092-uftc8inx 8698 10 discrepancy discrepancy NN cord-010092-uftc8inx 8698 11 in in IN cord-010092-uftc8inx 8698 12 a a DT cord-010092-uftc8inx 8698 13 Blood blood NN cord-010092-uftc8inx 8698 14 donor donor NN cord-010092-uftc8inx 8698 15 . . . cord-010092-uftc8inx 8699 1 The the DT cord-010092-uftc8inx 8699 2 donor donor NN cord-010092-uftc8inx 8699 3 's 's POS cord-010092-uftc8inx 8699 4 historic historic JJ cord-010092-uftc8inx 8699 5 phenotype phenotype NN cord-010092-uftc8inx 8699 6 c+ c+ XX cord-010092-uftc8inx 8700 1 ( ( -LRB- cord-010092-uftc8inx 8700 2 R r NN cord-010092-uftc8inx 8700 3 1 1 CD cord-010092-uftc8inx 8700 4 r r NN cord-010092-uftc8inx 8700 5 ) ) -RRB- cord-010092-uftc8inx 8700 6 was be VBD cord-010092-uftc8inx 8700 7 inconsistent inconsistent JJ cord-010092-uftc8inx 8700 8 with with IN cord-010092-uftc8inx 8700 9 the the DT cord-010092-uftc8inx 8700 10 current current JJ cord-010092-uftc8inx 8700 11 donation donation NN cord-010092-uftc8inx 8700 12 phenotype phenotype NN cord-010092-uftc8inx 8700 13 c-(R c-(r CC cord-010092-uftc8inx 8700 14 1 1 CD cord-010092-uftc8inx 8700 15 R r NN cord-010092-uftc8inx 8700 16 1 1 CD cord-010092-uftc8inx 8700 17 ) ) -RRB- cord-010092-uftc8inx 8700 18 . . . cord-010092-uftc8inx 8701 1 We -PRON- PRP cord-010092-uftc8inx 8701 2 aimed aim VBD cord-010092-uftc8inx 8701 3 to to TO cord-010092-uftc8inx 8701 4 investigate investigate VB cord-010092-uftc8inx 8701 5 the the DT cord-010092-uftc8inx 8701 6 cause cause NN cord-010092-uftc8inx 8701 7 of of IN cord-010092-uftc8inx 8701 8 the the DT cord-010092-uftc8inx 8701 9 discrepancy discrepancy NN cord-010092-uftc8inx 8701 10 so so IN cord-010092-uftc8inx 8701 11 the the DT cord-010092-uftc8inx 8701 12 donor donor NN cord-010092-uftc8inx 8701 13 could could MD cord-010092-uftc8inx 8701 14 be be VB cord-010092-uftc8inx 8701 15 assigned assign VBN cord-010092-uftc8inx 8701 16 the the DT cord-010092-uftc8inx 8701 17 correct correct JJ cord-010092-uftc8inx 8701 18 phenotype phenotype NN cord-010092-uftc8inx 8701 19 , , , cord-010092-uftc8inx 8701 20 identify identify VB cord-010092-uftc8inx 8701 21 the the DT cord-010092-uftc8inx 8701 22 root root NN cord-010092-uftc8inx 8701 23 cause cause NN cord-010092-uftc8inx 8701 24 of of IN cord-010092-uftc8inx 8701 25 the the DT cord-010092-uftc8inx 8701 26 discrepancy discrepancy NN cord-010092-uftc8inx 8701 27 and and CC cord-010092-uftc8inx 8701 28 implement implement VB cord-010092-uftc8inx 8701 29 any any DT cord-010092-uftc8inx 8701 30 corrective corrective JJ cord-010092-uftc8inx 8701 31 actions action NNS cord-010092-uftc8inx 8701 32 . . . cord-010092-uftc8inx 8702 1 Methods method NNS cord-010092-uftc8inx 8702 2 : : : cord-010092-uftc8inx 8702 3 The the DT cord-010092-uftc8inx 8702 4 donor donor NN cord-010092-uftc8inx 8702 5 's 's POS cord-010092-uftc8inx 8702 6 red red JJ cord-010092-uftc8inx 8702 7 cells cell NNS cord-010092-uftc8inx 8702 8 were be VBD cord-010092-uftc8inx 8702 9 phenotyped phenotype VBN cord-010092-uftc8inx 8702 10 with with IN cord-010092-uftc8inx 8702 11 all all DT cord-010092-uftc8inx 8702 12 available available JJ cord-010092-uftc8inx 8702 13 anti anti JJ cord-010092-uftc8inx 8702 14 - - JJ cord-010092-uftc8inx 8702 15 c c JJ cord-010092-uftc8inx 8702 16 reagents reagent NNS cord-010092-uftc8inx 8702 17 as as IN cord-010092-uftc8inx 8702 18 per per IN cord-010092-uftc8inx 8702 19 the the DT cord-010092-uftc8inx 8702 20 Manufacturers Manufacturers NNPS cord-010092-uftc8inx 8702 21 product product NN cord-010092-uftc8inx 8702 22 insert insert NN cord-010092-uftc8inx 8702 23 across across IN cord-010092-uftc8inx 8702 24 both both CC cord-010092-uftc8inx 8702 25 manual manual JJ cord-010092-uftc8inx 8702 26 and and CC cord-010092-uftc8inx 8702 27 automated automate VBN cord-010092-uftc8inx 8702 28 testing testing NN cord-010092-uftc8inx 8702 29 platforms platform NNS cord-010092-uftc8inx 8702 30 . . . cord-010092-uftc8inx 8703 1 Following follow VBG cord-010092-uftc8inx 8703 2 variable variable JJ cord-010092-uftc8inx 8703 3 results result NNS cord-010092-uftc8inx 8703 4 and and CC cord-010092-uftc8inx 8703 5 weaker weak JJR cord-010092-uftc8inx 8703 6 reactions reaction NNS cord-010092-uftc8inx 8703 7 with with IN cord-010092-uftc8inx 8703 8 some some DT cord-010092-uftc8inx 8703 9 reagents reagent NNS cord-010092-uftc8inx 8703 10 , , , cord-010092-uftc8inx 8703 11 DNA DNA NNP cord-010092-uftc8inx 8703 12 was be VBD cord-010092-uftc8inx 8703 13 extracted extract VBN cord-010092-uftc8inx 8703 14 from from IN cord-010092-uftc8inx 8703 15 the the DT cord-010092-uftc8inx 8703 16 EDTA EDTA NNP cord-010092-uftc8inx 8703 17 sample sample NN cord-010092-uftc8inx 8703 18 and and CC cord-010092-uftc8inx 8703 19 was be VBD cord-010092-uftc8inx 8703 20 genotyped genotype VBN cord-010092-uftc8inx 8703 21 using use VBG cord-010092-uftc8inx 8703 22 Immucor Immucor NNP cord-010092-uftc8inx 8703 23 BioArray BioArray NNP cord-010092-uftc8inx 8703 24 TM TM NNP cord-010092-uftc8inx 8703 25 HEA HEA NNP cord-010092-uftc8inx 8703 26 Precise Precise NNP cord-010092-uftc8inx 8703 27 and and CC cord-010092-uftc8inx 8703 28 RHCE RHCE NNP cord-010092-uftc8inx 8703 29 BeadChip BeadChip NNP cord-010092-uftc8inx 8703 30 TM TM NNP cord-010092-uftc8inx 8703 31 . . . cord-010092-uftc8inx 8704 1 Targeted target VBN cord-010092-uftc8inx 8704 2 DNA dna NN cord-010092-uftc8inx 8704 3 sequencing sequencing NN cord-010092-uftc8inx 8704 4 of of IN cord-010092-uftc8inx 8704 5 RHD RHD NNP cord-010092-uftc8inx 8704 6 and and CC cord-010092-uftc8inx 8704 7 RHCE RHCE NNP cord-010092-uftc8inx 8704 8 was be VBD cord-010092-uftc8inx 8704 9 also also RB cord-010092-uftc8inx 8704 10 performed perform VBN cord-010092-uftc8inx 8704 11 using use VBG cord-010092-uftc8inx 8704 12 the the DT cord-010092-uftc8inx 8704 13 Trusight Trusight NNP cord-010092-uftc8inx 8704 14 TM TM NNP cord-010092-uftc8inx 8704 15 One one CD cord-010092-uftc8inx 8704 16 sequencing sequencing NN cord-010092-uftc8inx 8704 17 panel panel NN cord-010092-uftc8inx 8704 18 . . . cord-010092-uftc8inx 8705 1 A a DT cord-010092-uftc8inx 8705 2 review review NN cord-010092-uftc8inx 8705 3 of of IN cord-010092-uftc8inx 8705 4 the the DT cord-010092-uftc8inx 8705 5 historical historical JJ cord-010092-uftc8inx 8705 6 phenotype phenotype NN cord-010092-uftc8inx 8705 7 results result NNS cord-010092-uftc8inx 8705 8 , , , cord-010092-uftc8inx 8705 9 including include VBG cord-010092-uftc8inx 8705 10 the the DT cord-010092-uftc8inx 8705 11 testing testing NN cord-010092-uftc8inx 8705 12 platform platform NN cord-010092-uftc8inx 8705 13 and and CC cord-010092-uftc8inx 8705 14 reagents reagent NNS cord-010092-uftc8inx 8705 15 used use VBN cord-010092-uftc8inx 8705 16 at at IN cord-010092-uftc8inx 8705 17 the the DT cord-010092-uftc8inx 8705 18 time time NN cord-010092-uftc8inx 8705 19 was be VBD cord-010092-uftc8inx 8705 20 also also RB cord-010092-uftc8inx 8705 21 performed perform VBN cord-010092-uftc8inx 8705 22 . . . cord-010092-uftc8inx 8706 1 Results result NNS cord-010092-uftc8inx 8706 2 : : : cord-010092-uftc8inx 8707 1 On on IN cord-010092-uftc8inx 8707 2 the the DT cord-010092-uftc8inx 8707 3 current current JJ cord-010092-uftc8inx 8707 4 sample sample NN cord-010092-uftc8inx 8707 5 the the DT cord-010092-uftc8inx 8707 6 donor donor NN cord-010092-uftc8inx 8707 7 's 's POS cord-010092-uftc8inx 8707 8 red red JJ cord-010092-uftc8inx 8707 9 cells cell NNS cord-010092-uftc8inx 8707 10 gave give VBD cord-010092-uftc8inx 8707 11 a a DT cord-010092-uftc8inx 8707 12 2 2 CD cord-010092-uftc8inx 8707 13 + + CD cord-010092-uftc8inx 8707 14 reaction reaction NN cord-010092-uftc8inx 8707 15 by by IN cord-010092-uftc8inx 8707 16 tube tube NN cord-010092-uftc8inx 8707 17 with with IN cord-010092-uftc8inx 8707 18 Bio Bio NNP cord-010092-uftc8inx 8707 19 - - HYPH cord-010092-uftc8inx 8707 20 Rad Rad NNP cord-010092-uftc8inx 8707 21 Seraclone Seraclone NNP cord-010092-uftc8inx 8707 22 â â , cord-010092-uftc8inx 8707 23 ( ( -LRB- cord-010092-uftc8inx 8707 24 2 2 CD cord-010092-uftc8inx 8707 25 ) ) -RRB- cord-010092-uftc8inx 8708 1 [ [ -LRB- cord-010092-uftc8inx 8708 2 clone clone NN cord-010092-uftc8inx 8708 3 MS35 MS35 NNP cord-010092-uftc8inx 8708 4 ] ] -RRB- cord-010092-uftc8inx 8708 5 and and CC cord-010092-uftc8inx 8708 6 Immulab Immulab NNP cord-010092-uftc8inx 8708 7 Epiclone Epiclone NNP cord-010092-uftc8inx 8708 8 TM TM NNP cord-010092-uftc8inx 8709 1 [ [ -LRB- cord-010092-uftc8inx 8709 2 clone clone NNP cord-010092-uftc8inx 8709 3 anti anti JJ cord-010092-uftc8inx 8709 4 - - JJ cord-010092-uftc8inx 8709 5 c c JJ cord-010092-uftc8inx 8709 6 reagents reagent NNS cord-010092-uftc8inx 8709 7 . . . cord-010092-uftc8inx 8710 1 The the DT cord-010092-uftc8inx 8710 2 sample sample NN cord-010092-uftc8inx 8710 3 tested test VBD cord-010092-uftc8inx 8710 4 negative negative JJ cord-010092-uftc8inx 8710 5 on on IN cord-010092-uftc8inx 8710 6 the the DT cord-010092-uftc8inx 8710 7 Beckman Beckman NNP cord-010092-uftc8inx 8710 8 Coulter Coulter NNP cord-010092-uftc8inx 8710 9 PK7300 PK7300 NNP cord-010092-uftc8inx 8710 10 using use VBG cord-010092-uftc8inx 8710 11 Beckman Beckman NNP cord-010092-uftc8inx 8710 12 Coulter Coulter NNP cord-010092-uftc8inx 8710 13 anti anti JJ cord-010092-uftc8inx 8710 14 - - NN cord-010092-uftc8inx 8710 15 c c JJ cord-010092-uftc8inx 8710 16 [ [ -LRB- cord-010092-uftc8inx 8710 17 clone clone NN cord-010092-uftc8inx 8710 18 951 951 CD cord-010092-uftc8inx 8710 19 ] ] -RRB- cord-010092-uftc8inx 8711 1 blood blood NN cord-010092-uftc8inx 8711 2 grouping grouping NN cord-010092-uftc8inx 8711 3 reagent reagent NN cord-010092-uftc8inx 8711 4 and and CC cord-010092-uftc8inx 8711 5 tested test VBN cord-010092-uftc8inx 8711 6 positive positive JJ cord-010092-uftc8inx 8711 7 ( ( -LRB- cord-010092-uftc8inx 8711 8 4 4 CD cord-010092-uftc8inx 8711 9 ) ) -RRB- cord-010092-uftc8inx 8711 10 reaction reaction NN cord-010092-uftc8inx 8711 11 on on IN cord-010092-uftc8inx 8711 12 the the DT cord-010092-uftc8inx 8711 13 Immucor Immucor NNP cord-010092-uftc8inx 8711 14 NEO NEO NNP cord-010092-uftc8inx 8711 15 using use VBG cord-010092-uftc8inx 8711 16 ImmuClone ImmuClone NNP cord-010092-uftc8inx 8711 17 â â , cord-010092-uftc8inx 8711 18 ( ( -LRB- cord-010092-uftc8inx 8711 19 1 1 LS cord-010092-uftc8inx 8711 20 ) ) -RRB- cord-010092-uftc8inx 8711 21 anti anti NNS cord-010092-uftc8inx 8711 22 - - NN cord-010092-uftc8inx 8711 23 c c JJ cord-010092-uftc8inx 8711 24 [ [ -LRB- cord-010092-uftc8inx 8711 25 clone clone NN cord-010092-uftc8inx 8711 26 . . . cord-010092-uftc8inx 8712 1 Immucor Immucor NNP cord-010092-uftc8inx 8712 2 BioArray BioArray NNP cord-010092-uftc8inx 8713 1 TM TM NNP cord-010092-uftc8inx 8713 2 HEA HEA NNP cord-010092-uftc8inx 8713 3 Precise Precise NNP cord-010092-uftc8inx 8713 4 BeadChip BeadChip NNP cord-010092-uftc8inx 8713 5 TM TM NNP cord-010092-uftc8inx 8713 6 predicted predict VBD cord-010092-uftc8inx 8713 7 a a DT cord-010092-uftc8inx 8713 8 c+ c+ CD cord-010092-uftc8inx 8713 9 phenotype phenotype NN cord-010092-uftc8inx 8713 10 and and CC cord-010092-uftc8inx 8713 11 no no DT cord-010092-uftc8inx 8713 12 variants variant NNS cord-010092-uftc8inx 8713 13 were be VBD cord-010092-uftc8inx 8713 14 detected detect VBN cord-010092-uftc8inx 8713 15 with with IN cord-010092-uftc8inx 8713 16 the the DT cord-010092-uftc8inx 8713 17 BioArray BioArray NNP cord-010092-uftc8inx 8713 18 TM TM NNP cord-010092-uftc8inx 8713 19 RHCE RHCE NNP cord-010092-uftc8inx 8713 20 BeadChip BeadChip NNP cord-010092-uftc8inx 8713 21 TM TM NNP cord-010092-uftc8inx 8713 22 . . . cord-010092-uftc8inx 8714 1 The the DT cord-010092-uftc8inx 8714 2 Trusight Trusight NNP cord-010092-uftc8inx 8714 3 TM TM NNP cord-010092-uftc8inx 8714 4 One one CD cord-010092-uftc8inx 8714 5 sequencing sequencing NN cord-010092-uftc8inx 8714 6 panel panel NN cord-010092-uftc8inx 8714 7 genotyped genotype VBD cord-010092-uftc8inx 8714 8 the the DT cord-010092-uftc8inx 8714 9 donor donor NN cord-010092-uftc8inx 8714 10 as as IN cord-010092-uftc8inx 8714 11 RHD*01/*01N.01 rhd*01/*01n.01 CD cord-010092-uftc8inx 8714 12 and and CC cord-010092-uftc8inx 8714 13 RHCE*01.15/*02 RHCE*01.15/*02 NNP cord-010092-uftc8inx 8714 14 with with IN cord-010092-uftc8inx 8714 15 a a DT cord-010092-uftc8inx 8714 16 predicted predict VBN cord-010092-uftc8inx 8714 17 phenotype phenotype NN cord-010092-uftc8inx 8714 18 of of IN cord-010092-uftc8inx 8714 19 C+ C+ NNP cord-010092-uftc8inx 8714 20 , , , cord-010092-uftc8inx 8714 21 c+ c+ NNP cord-010092-uftc8inx 8714 22 w w NN cord-010092-uftc8inx 8714 23 , , , cord-010092-uftc8inx 8714 24 D+ D+ NNS cord-010092-uftc8inx 8714 25 , , , cord-010092-uftc8inx 8714 26 E- E- NNP cord-010092-uftc8inx 8714 27 , , , cord-010092-uftc8inx 8714 28 e+ e+ NNP cord-010092-uftc8inx 8714 29 , , , cord-010092-uftc8inx 8714 30 RH:55 RH:55 NNP cord-010092-uftc8inx 8714 31 ( ( -LRB- cord-010092-uftc8inx 8714 32 LOCR+ LOCR+ NNP cord-010092-uftc8inx 8714 33 ) ) -RRB- cord-010092-uftc8inx 8714 34 , , , cord-010092-uftc8inx 8714 35 RH:-26 RH:-26 NNP cord-010092-uftc8inx 8714 36 . . . cord-010092-uftc8inx 8715 1 A a DT cord-010092-uftc8inx 8715 2 review review NN cord-010092-uftc8inx 8715 3 of of IN cord-010092-uftc8inx 8715 4 the the DT cord-010092-uftc8inx 8715 5 donor donor NN cord-010092-uftc8inx 8715 6 's 's POS cord-010092-uftc8inx 8715 7 historical historical JJ cord-010092-uftc8inx 8715 8 records record NNS cord-010092-uftc8inx 8715 9 indicated indicate VBD cord-010092-uftc8inx 8715 10 the the DT cord-010092-uftc8inx 8715 11 donor donor NN cord-010092-uftc8inx 8715 12 tested test VBN cord-010092-uftc8inx 8715 13 as as IN cord-010092-uftc8inx 8715 14 c+ c+ NNP cord-010092-uftc8inx 8715 15 on on IN cord-010092-uftc8inx 8715 16 the the DT cord-010092-uftc8inx 8715 17 PK7200 PK7200 NNP cord-010092-uftc8inx 8715 18 , , , cord-010092-uftc8inx 8715 19 which which WDT cord-010092-uftc8inx 8715 20 at at IN cord-010092-uftc8inx 8715 21 the the DT cord-010092-uftc8inx 8715 22 time time NN cord-010092-uftc8inx 8715 23 was be VBD cord-010092-uftc8inx 8715 24 being be VBG cord-010092-uftc8inx 8715 25 used use VBN cord-010092-uftc8inx 8715 26 with with IN cord-010092-uftc8inx 8715 27 an an DT cord-010092-uftc8inx 8715 28 in in IN cord-010092-uftc8inx 8715 29 - - HYPH cord-010092-uftc8inx 8715 30 house house NN cord-010092-uftc8inx 8715 31 Bromelain bromelain NN cord-010092-uftc8inx 8715 32 preparation preparation NN cord-010092-uftc8inx 8715 33 ( ( -LRB- cord-010092-uftc8inx 8715 34 Sigma Sigma NNP cord-010092-uftc8inx 8715 35 - - HYPH cord-010092-uftc8inx 8715 36 Aldrich Aldrich NNP cord-010092-uftc8inx 8715 37 ) ) -RRB- cord-010092-uftc8inx 8715 38 and and CC cord-010092-uftc8inx 8715 39 Diagast Diagast NNP cord-010092-uftc8inx 8715 40 Olymp Olymp NNP cord-010092-uftc8inx 8715 41 Pheno Pheno NNP cord-010092-uftc8inx 8715 42 anti anti JJ cord-010092-uftc8inx 8715 43 - - JJ cord-010092-uftc8inx 8715 44 c c JJ cord-010092-uftc8inx 8715 45 reagent reagent NN cord-010092-uftc8inx 8715 46 [ [ -LRB- cord-010092-uftc8inx 8715 47 clone clone NN cord-010092-uftc8inx 8715 48 MS33 MS33 NNP cord-010092-uftc8inx 8715 49 ] ] -RRB- cord-010092-uftc8inx 8715 50 . . . cord-010092-uftc8inx 8716 1 Summary Summary NNP cord-010092-uftc8inx 8716 2 / / SYM cord-010092-uftc8inx 8716 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 8716 4 : : : cord-010092-uftc8inx 8717 1 Results result NNS cord-010092-uftc8inx 8717 2 indicated indicate VBD cord-010092-uftc8inx 8717 3 the the DT cord-010092-uftc8inx 8717 4 phenotype phenotype NN cord-010092-uftc8inx 8717 5 discrepancy discrepancy NN cord-010092-uftc8inx 8717 6 was be VBD cord-010092-uftc8inx 8717 7 caused cause VBN cord-010092-uftc8inx 8717 8 by by IN cord-010092-uftc8inx 8717 9 the the DT cord-010092-uftc8inx 8717 10 c+ c+ NNP cord-010092-uftc8inx 8717 11 Rh:-26 Rh:-26 NNP cord-010092-uftc8inx 8717 12 variant variant NN cord-010092-uftc8inx 8717 13 associated associate VBN cord-010092-uftc8inx 8717 14 with with IN cord-010092-uftc8inx 8717 15 the the DT cord-010092-uftc8inx 8717 16 RHCE*01.15 RHCE*01.15 NNP cord-010092-uftc8inx 8717 17 allele allele NN cord-010092-uftc8inx 8717 18 . . . cord-010092-uftc8inx 8718 1 Reagents reagent NNS cord-010092-uftc8inx 8718 2 containing contain VBG cord-010092-uftc8inx 8718 3 clones clone NNS cord-010092-uftc8inx 8718 4 MS-33 MS-33 NNP cord-010092-uftc8inx 8719 1 and and CC cord-010092-uftc8inx 8719 2 MS35 MS35 NNP cord-010092-uftc8inx 8719 3 correctly correctly RB cord-010092-uftc8inx 8719 4 phenotyped phenotype VBD cord-010092-uftc8inx 8719 5 the the DT cord-010092-uftc8inx 8719 6 donor donor NN cord-010092-uftc8inx 8719 7 as as IN cord-010092-uftc8inx 8719 8 c+ c+ NNP cord-010092-uftc8inx 8719 9 , , , cord-010092-uftc8inx 8719 10 with with IN cord-010092-uftc8inx 8719 11 the the DT cord-010092-uftc8inx 8719 12 manual manual JJ cord-010092-uftc8inx 8719 13 tube tube NN cord-010092-uftc8inx 8719 14 reagents reagent NNS cord-010092-uftc8inx 8719 15 showing show VBG cord-010092-uftc8inx 8719 16 a a DT cord-010092-uftc8inx 8719 17 weaker weak JJR cord-010092-uftc8inx 8719 18 reaction reaction NN cord-010092-uftc8inx 8719 19 which which WDT cord-010092-uftc8inx 8719 20 may may MD cord-010092-uftc8inx 8719 21 alert alert VB cord-010092-uftc8inx 8719 22 the the DT cord-010092-uftc8inx 8719 23 operator operator NN cord-010092-uftc8inx 8719 24 to to IN cord-010092-uftc8inx 8719 25 a a DT cord-010092-uftc8inx 8719 26 possible possible JJ cord-010092-uftc8inx 8719 27 variant variant NN cord-010092-uftc8inx 8719 28 which which WDT cord-010092-uftc8inx 8719 29 is be VBZ cord-010092-uftc8inx 8719 30 important important JJ cord-010092-uftc8inx 8719 31 in in IN cord-010092-uftc8inx 8719 32 the the DT cord-010092-uftc8inx 8719 33 patient patient NN cord-010092-uftc8inx 8719 34 setting setting NN cord-010092-uftc8inx 8719 35 . . . cord-010092-uftc8inx 8720 1 The the DT cord-010092-uftc8inx 8720 2 Beckman Beckman NNP cord-010092-uftc8inx 8720 3 Coulter Coulter NNP cord-010092-uftc8inx 8720 4 PK7300 PK7300 NNP cord-010092-uftc8inx 8720 5 and and CC cord-010092-uftc8inx 8720 6 associated associated JJ cord-010092-uftc8inx 8720 7 anti anti NN cord-010092-uftc8inx 8720 8 - - NN cord-010092-uftc8inx 8720 9 c c JJ cord-010092-uftc8inx 8720 10 [ [ -LRB- cord-010092-uftc8inx 8720 11 clone clone NN cord-010092-uftc8inx 8720 12 951 951 CD cord-010092-uftc8inx 8720 13 ] ] -RRB- cord-010092-uftc8inx 8720 14 failed fail VBD cord-010092-uftc8inx 8720 15 to to TO cord-010092-uftc8inx 8720 16 detect detect VB cord-010092-uftc8inx 8720 17 the the DT cord-010092-uftc8inx 8720 18 c c NN cord-010092-uftc8inx 8720 19 antigen antigen NN cord-010092-uftc8inx 8720 20 . . . cord-010092-uftc8inx 8721 1 This this DT cord-010092-uftc8inx 8721 2 reagent reagent NN cord-010092-uftc8inx 8721 3 appears appear VBZ cord-010092-uftc8inx 8721 4 not not RB cord-010092-uftc8inx 8721 5 to to TO cord-010092-uftc8inx 8721 6 detect detect VB cord-010092-uftc8inx 8721 7 the the DT cord-010092-uftc8inx 8721 8 c c NN cord-010092-uftc8inx 8721 9 antigen antigen NN cord-010092-uftc8inx 8721 10 where where WRB cord-010092-uftc8inx 8721 11 it -PRON- PRP cord-010092-uftc8inx 8721 12 is be VBZ cord-010092-uftc8inx 8721 13 associated associate VBN cord-010092-uftc8inx 8721 14 with with IN cord-010092-uftc8inx 8721 15 the the DT cord-010092-uftc8inx 8721 16 Rh:-26 Rh:-26 NNP cord-010092-uftc8inx 8721 17 phenotype phenotype NN cord-010092-uftc8inx 8721 18 , , , cord-010092-uftc8inx 8721 19 which which WDT cord-010092-uftc8inx 8721 20 is be VBZ cord-010092-uftc8inx 8721 21 in in IN cord-010092-uftc8inx 8721 22 contrast contrast NN cord-010092-uftc8inx 8721 23 to to IN cord-010092-uftc8inx 8721 24 the the DT cord-010092-uftc8inx 8721 25 previous previous JJ cord-010092-uftc8inx 8721 26 report report NN cord-010092-uftc8inx 8721 27 by by IN cord-010092-uftc8inx 8721 28 Faas Faas NNP cord-010092-uftc8inx 8721 29 et et FW cord-010092-uftc8inx 8721 30 al al NNP cord-010092-uftc8inx 8721 31 , , , cord-010092-uftc8inx 8721 32 Transfusion Transfusion NNP cord-010092-uftc8inx 8721 33 , , , cord-010092-uftc8inx 8721 34 1997 1997 CD cord-010092-uftc8inx 8721 35 where where WRB cord-010092-uftc8inx 8721 36 it -PRON- PRP cord-010092-uftc8inx 8721 37 was be VBD cord-010092-uftc8inx 8721 38 demonstrated demonstrate VBN cord-010092-uftc8inx 8721 39 that that IN cord-010092-uftc8inx 8721 40 clone clone NN cord-010092-uftc8inx 8721 41 951 951 CD cord-010092-uftc8inx 8721 42 reacted react VBD cord-010092-uftc8inx 8721 43 with with IN cord-010092-uftc8inx 8721 44 c+ c+ `` cord-010092-uftc8inx 8721 45 Rh:-26 Rh:-26 NNP cord-010092-uftc8inx 8721 46 bromelain bromelain NN cord-010092-uftc8inx 8721 47 treated treat VBD cord-010092-uftc8inx 8721 48 red red JJ cord-010092-uftc8inx 8721 49 cells cell NNS cord-010092-uftc8inx 8721 50 . . . cord-010092-uftc8inx 8722 1 Abstract Abstract NNP cord-010092-uftc8inx 8722 2 withdrawn withdraw VBN cord-010092-uftc8inx 8722 3 . . . cord-010092-uftc8inx 8723 1 Background background NN cord-010092-uftc8inx 8723 2 : : : cord-010092-uftc8inx 8724 1 Although although IN cord-010092-uftc8inx 8724 2 serological serological JJ cord-010092-uftc8inx 8724 3 RhD rhd NN cord-010092-uftc8inx 8724 4 typing typing NN cord-010092-uftc8inx 8724 5 has have VBZ cord-010092-uftc8inx 8724 6 always always RB cord-010092-uftc8inx 8724 7 been be VBN cord-010092-uftc8inx 8724 8 challenging challenge VBG cord-010092-uftc8inx 8724 9 due due IN cord-010092-uftc8inx 8724 10 to to IN cord-010092-uftc8inx 8724 11 variation variation NN cord-010092-uftc8inx 8724 12 of of IN cord-010092-uftc8inx 8724 13 techniques technique NNS cord-010092-uftc8inx 8724 14 and and CC cord-010092-uftc8inx 8724 15 variable variable JJ cord-010092-uftc8inx 8724 16 sensitivity sensitivity NN cord-010092-uftc8inx 8724 17 of of IN cord-010092-uftc8inx 8724 18 anti anti JJ cord-010092-uftc8inx 8724 19 - - JJ cord-010092-uftc8inx 8724 20 D d JJ cord-010092-uftc8inx 8724 21 reagents reagent NNS cord-010092-uftc8inx 8724 22 , , , cord-010092-uftc8inx 8724 23 most most JJS cord-010092-uftc8inx 8724 24 individuals individual NNS cord-010092-uftc8inx 8724 25 are be VBP cord-010092-uftc8inx 8724 26 unequivocally unequivocally RB cord-010092-uftc8inx 8724 27 typed type VBN cord-010092-uftc8inx 8724 28 as as IN cord-010092-uftc8inx 8724 29 either either DT cord-010092-uftc8inx 8724 30 RhD rhd NN cord-010092-uftc8inx 8724 31 positive positive JJ cord-010092-uftc8inx 8724 32 or or CC cord-010092-uftc8inx 8724 33 RhD rhd NN cord-010092-uftc8inx 8724 34 negative negative JJ cord-010092-uftc8inx 8724 35 . . . cord-010092-uftc8inx 8725 1 However however RB cord-010092-uftc8inx 8725 2 , , , cord-010092-uftc8inx 8725 3 variants variant NNS cord-010092-uftc8inx 8725 4 of of IN cord-010092-uftc8inx 8725 5 D D NNP cord-010092-uftc8inx 8725 6 ( ( -LRB- cord-010092-uftc8inx 8725 7 weak weak JJ cord-010092-uftc8inx 8725 8 D d NN cord-010092-uftc8inx 8725 9 and and CC cord-010092-uftc8inx 8725 10 partial partial JJ cord-010092-uftc8inx 8725 11 D d NN cord-010092-uftc8inx 8725 12 phenotypes phenotype NNS cord-010092-uftc8inx 8725 13 ) ) -RRB- cord-010092-uftc8inx 8725 14 may may MD cord-010092-uftc8inx 8725 15 present present VB cord-010092-uftc8inx 8725 16 typing typing NN cord-010092-uftc8inx 8725 17 difficulties difficulty NNS cord-010092-uftc8inx 8725 18 . . . cord-010092-uftc8inx 8726 1 Individuals individual NNS cord-010092-uftc8inx 8726 2 with with IN cord-010092-uftc8inx 8726 3 partial partial JJ cord-010092-uftc8inx 8726 4 D d NN cord-010092-uftc8inx 8726 5 ( ( -LRB- cord-010092-uftc8inx 8726 6 missing miss VBG cord-010092-uftc8inx 8726 7 epitopes epitope NNS cord-010092-uftc8inx 8726 8 of of IN cord-010092-uftc8inx 8726 9 the the DT cord-010092-uftc8inx 8726 10 D D NNP cord-010092-uftc8inx 8726 11 antigen antigen NNP cord-010092-uftc8inx 8726 12 ) ) -RRB- cord-010092-uftc8inx 8726 13 must must MD cord-010092-uftc8inx 8726 14 be be VB cord-010092-uftc8inx 8726 15 typed type VBN cord-010092-uftc8inx 8726 16 as as IN cord-010092-uftc8inx 8726 17 RhD rhd NN cord-010092-uftc8inx 8726 18 negative negative JJ cord-010092-uftc8inx 8726 19 as as IN cord-010092-uftc8inx 8726 20 blood blood NN cord-010092-uftc8inx 8726 21 receivers receiver NNS cord-010092-uftc8inx 8726 22 , , , cord-010092-uftc8inx 8726 23 but but CC cord-010092-uftc8inx 8726 24 as as IN cord-010092-uftc8inx 8726 25 RhD rhd NN cord-010092-uftc8inx 8726 26 positive positive JJ cord-010092-uftc8inx 8726 27 , , , cord-010092-uftc8inx 8726 28 as as IN cord-010092-uftc8inx 8726 29 blood blood NN cord-010092-uftc8inx 8726 30 donors donor NNS cord-010092-uftc8inx 8726 31 . . . cord-010092-uftc8inx 8727 1 Aims aim VBZ cord-010092-uftc8inx 8727 2 : : : cord-010092-uftc8inx 8728 1 The the DT cord-010092-uftc8inx 8728 2 aim aim NN cord-010092-uftc8inx 8728 3 of of IN cord-010092-uftc8inx 8728 4 our -PRON- PRP$ cord-010092-uftc8inx 8728 5 study study NN cord-010092-uftc8inx 8728 6 was be VBD cord-010092-uftc8inx 8728 7 to to TO cord-010092-uftc8inx 8728 8 evaluate evaluate VB cord-010092-uftc8inx 8728 9 the the DT cord-010092-uftc8inx 8728 10 algorithm algorithm NN cord-010092-uftc8inx 8728 11 used use VBN cord-010092-uftc8inx 8728 12 since since IN cord-010092-uftc8inx 8728 13 2017 2017 CD cord-010092-uftc8inx 8728 14 at at IN cord-010092-uftc8inx 8728 15 AHEPA AHEPA NNP cord-010092-uftc8inx 8728 16 University University NNP cord-010092-uftc8inx 8728 17 Blood Blood NNP cord-010092-uftc8inx 8728 18 Center Center NNP cord-010092-uftc8inx 8728 19 , , , cord-010092-uftc8inx 8728 20 to to TO cord-010092-uftc8inx 8728 21 resolve resolve VB cord-010092-uftc8inx 8728 22 RhD rhd NN cord-010092-uftc8inx 8728 23 typing typing NN cord-010092-uftc8inx 8728 24 problems problem NNS cord-010092-uftc8inx 8728 25 among among IN cord-010092-uftc8inx 8728 26 first first JJ cord-010092-uftc8inx 8728 27 time time NN cord-010092-uftc8inx 8728 28 donors donor NNS cord-010092-uftc8inx 8728 29 . . . cord-010092-uftc8inx 8729 1 Methods method NNS cord-010092-uftc8inx 8729 2 : : : cord-010092-uftc8inx 8729 3 Since since IN cord-010092-uftc8inx 8729 4 automatic automatic JJ cord-010092-uftc8inx 8729 5 analyzers analyzer NNS cord-010092-uftc8inx 8729 6 may may MD cord-010092-uftc8inx 8729 7 type type VB cord-010092-uftc8inx 8729 8 variants variant NNS cord-010092-uftc8inx 8729 9 of of IN cord-010092-uftc8inx 8729 10 RhD rhd NN cord-010092-uftc8inx 8729 11 as as IN cord-010092-uftc8inx 8729 12 RhD+ RhD+ NNP cord-010092-uftc8inx 8729 13 , , , cord-010092-uftc8inx 8729 14 our -PRON- PRP$ cord-010092-uftc8inx 8729 15 practice practice NN cord-010092-uftc8inx 8729 16 is be VBZ cord-010092-uftc8inx 8729 17 to to TO cord-010092-uftc8inx 8729 18 routinely routinely RB cord-010092-uftc8inx 8729 19 perform perform VB cord-010092-uftc8inx 8729 20 two two CD cord-010092-uftc8inx 8729 21 different different JJ cord-010092-uftc8inx 8729 22 typing typing NN cord-010092-uftc8inx 8729 23 methods method NNS cord-010092-uftc8inx 8729 24 in in IN cord-010092-uftc8inx 8729 25 first first JJ cord-010092-uftc8inx 8729 26 time time NN cord-010092-uftc8inx 8729 27 donors donor NNS cord-010092-uftc8inx 8729 28 : : : cord-010092-uftc8inx 8729 29 an an DT cord-010092-uftc8inx 8729 30 automated automate VBN cord-010092-uftc8inx 8729 31 microplate microplate NN cord-010092-uftc8inx 8729 32 method method NN cord-010092-uftc8inx 8729 33 on on IN cord-010092-uftc8inx 8729 34 the the DT cord-010092-uftc8inx 8729 35 Neo Neo NNP cord-010092-uftc8inx 8729 36 analyzer analyzer NN cord-010092-uftc8inx 8729 37 ( ( -LRB- cord-010092-uftc8inx 8729 38 Immucor Immucor NNP cord-010092-uftc8inx 8729 39 ) ) -RRB- cord-010092-uftc8inx 8729 40 and and CC cord-010092-uftc8inx 8729 41 the the DT cord-010092-uftc8inx 8729 42 slide slide NN cord-010092-uftc8inx 8729 43 test test NN cord-010092-uftc8inx 8729 44 , , , cord-010092-uftc8inx 8729 45 using use VBG cord-010092-uftc8inx 8729 46 a a DT cord-010092-uftc8inx 8729 47 potent potent JJ cord-010092-uftc8inx 8729 48 reagent reagent NN cord-010092-uftc8inx 8729 49 ( ( -LRB- cord-010092-uftc8inx 8729 50 anti anti JJ cord-010092-uftc8inx 8729 51 - - JJ cord-010092-uftc8inx 8729 52 D d JJ cord-010092-uftc8inx 8729 53 Blend Blend NNP cord-010092-uftc8inx 8729 54 - - HYPH cord-010092-uftc8inx 8729 55 Immunodiagnostika Immunodiagnostika NNP cord-010092-uftc8inx 8729 56 ) ) -RRB- cord-010092-uftc8inx 8729 57 . . . cord-010092-uftc8inx 8730 1 In in IN cord-010092-uftc8inx 8730 2 case case NN cord-010092-uftc8inx 8730 3 of of IN cord-010092-uftc8inx 8730 4 negative negative JJ cord-010092-uftc8inx 8730 5 , , , cord-010092-uftc8inx 8730 6 weak weak JJ cord-010092-uftc8inx 8730 7 , , , cord-010092-uftc8inx 8730 8 slow slow JJ cord-010092-uftc8inx 8730 9 or or CC cord-010092-uftc8inx 8730 10 mixed mixed JJ cord-010092-uftc8inx 8730 11 - - HYPH cord-010092-uftc8inx 8730 12 field field NN cord-010092-uftc8inx 8730 13 reaction reaction NN cord-010092-uftc8inx 8730 14 , , , cord-010092-uftc8inx 8730 15 further further RB cord-010092-uftc8inx 8730 16 testing testing NN cord-010092-uftc8inx 8730 17 with with IN cord-010092-uftc8inx 8730 18 an an DT cord-010092-uftc8inx 8730 19 automated automate VBN cord-010092-uftc8inx 8730 20 microplate microplate JJ cord-010092-uftc8inx 8730 21 Weak Weak NNP cord-010092-uftc8inx 8730 22 D d NN cord-010092-uftc8inx 8730 23 method method NN cord-010092-uftc8inx 8730 24 [ [ -LRB- cord-010092-uftc8inx 8730 25 Immucor Immucor NNP cord-010092-uftc8inx 8730 26 - - HYPH cord-010092-uftc8inx 8730 27 modified modify VBN cord-010092-uftc8inx 8730 28 indirect indirect JJ cord-010092-uftc8inx 8730 29 antiglobulin antiglobulin NN cord-010092-uftc8inx 8730 30 ( ( -LRB- cord-010092-uftc8inx 8730 31 anti anti JJ cord-010092-uftc8inx 8730 32 - - JJ cord-010092-uftc8inx 8730 33 IgG igg JJ cord-010092-uftc8inx 8730 34 ) ) -RRB- cord-010092-uftc8inx 8730 35 test test NN cord-010092-uftc8inx 8730 36 ] ] -RRB- cord-010092-uftc8inx 8730 37 follows follow VBZ cord-010092-uftc8inx 8730 38 . . . cord-010092-uftc8inx 8731 1 The the DT cord-010092-uftc8inx 8731 2 next next JJ cord-010092-uftc8inx 8731 3 step step NN cord-010092-uftc8inx 8731 4 of of IN cord-010092-uftc8inx 8731 5 the the DT cord-010092-uftc8inx 8731 6 protocol protocol NN cord-010092-uftc8inx 8731 7 consists consist VBZ cord-010092-uftc8inx 8731 8 of of IN cord-010092-uftc8inx 8731 9 testing testing NN cord-010092-uftc8inx 8731 10 with with IN cord-010092-uftc8inx 8731 11 the the DT cord-010092-uftc8inx 8731 12 commercial commercial JJ cord-010092-uftc8inx 8731 13 ID ID NNP cord-010092-uftc8inx 8731 14 - - HYPH cord-010092-uftc8inx 8731 15 Partial partial JJ cord-010092-uftc8inx 8731 16 RhD rhd NN cord-010092-uftc8inx 8731 17 Typing typing NN cord-010092-uftc8inx 8731 18 kit kit NN cord-010092-uftc8inx 8731 19 ( ( -LRB- cord-010092-uftc8inx 8731 20 Bio Bio NNP cord-010092-uftc8inx 8731 21 - - HYPH cord-010092-uftc8inx 8731 22 Rad Rad NNP cord-010092-uftc8inx 8731 23 ) ) -RRB- cord-010092-uftc8inx 8731 24 comprising comprise VBG cord-010092-uftc8inx 8731 25 a a DT cord-010092-uftc8inx 8731 26 panel panel NN cord-010092-uftc8inx 8731 27 of of IN cord-010092-uftc8inx 8731 28 6 6 CD cord-010092-uftc8inx 8731 29 monoclonal monoclonal JJ cord-010092-uftc8inx 8731 30 anti anti JJ cord-010092-uftc8inx 8731 31 - - JJ cord-010092-uftc8inx 8731 32 D d JJ cord-010092-uftc8inx 8731 33 reagents reagent NNS cord-010092-uftc8inx 8731 34 , , , cord-010092-uftc8inx 8731 35 in in IN cord-010092-uftc8inx 8731 36 an an DT cord-010092-uftc8inx 8731 37 indirect indirect JJ cord-010092-uftc8inx 8731 38 Coombs Coombs NNP cord-010092-uftc8inx 8731 39 gel gel NN cord-010092-uftc8inx 8731 40 test test NN cord-010092-uftc8inx 8731 41 assay assay NN cord-010092-uftc8inx 8731 42 . . . cord-010092-uftc8inx 8732 1 The the DT cord-010092-uftc8inx 8732 2 patterns pattern NNS cord-010092-uftc8inx 8732 3 obtained obtain VBN cord-010092-uftc8inx 8732 4 with with IN cord-010092-uftc8inx 8732 5 this this DT cord-010092-uftc8inx 8732 6 kit kit NN cord-010092-uftc8inx 8732 7 can can MD cord-010092-uftc8inx 8732 8 distinguish distinguish VB cord-010092-uftc8inx 8732 9 between between IN cord-010092-uftc8inx 8732 10 D d NN cord-010092-uftc8inx 8732 11 weak weak JJ cord-010092-uftc8inx 8732 12 and and CC cord-010092-uftc8inx 8732 13 partial partial JJ cord-010092-uftc8inx 8732 14 D d NN cord-010092-uftc8inx 8732 15 and and CC cord-010092-uftc8inx 8732 16 can can MD cord-010092-uftc8inx 8732 17 also also RB cord-010092-uftc8inx 8732 18 differentiate differentiate VB cord-010092-uftc8inx 8732 19 between between IN cord-010092-uftc8inx 8732 20 categories category NNS cord-010092-uftc8inx 8732 21 II II NNP cord-010092-uftc8inx 8732 22 , , , cord-010092-uftc8inx 8732 23 IV IV NNP cord-010092-uftc8inx 8732 24 , , , cord-010092-uftc8inx 8732 25 V v NN cord-010092-uftc8inx 8732 26 , , , cord-010092-uftc8inx 8732 27 VI VI NNP cord-010092-uftc8inx 8732 28 , , , cord-010092-uftc8inx 8732 29 VII VII NNP cord-010092-uftc8inx 8732 30 DFR DFR NNP cord-010092-uftc8inx 8732 31 , , , cord-010092-uftc8inx 8732 32 DBT DBT NNP cord-010092-uftc8inx 8732 33 and and CC cord-010092-uftc8inx 8732 34 DHAR DHAR NNP cord-010092-uftc8inx 8732 35 . . . cord-010092-uftc8inx 8733 1 The the DT cord-010092-uftc8inx 8733 2 last last JJ cord-010092-uftc8inx 8733 3 step step NN cord-010092-uftc8inx 8733 4 of of IN cord-010092-uftc8inx 8733 5 our -PRON- PRP$ cord-010092-uftc8inx 8733 6 algorithm algorithm NN cord-010092-uftc8inx 8733 7 consists consist VBZ cord-010092-uftc8inx 8733 8 of of IN cord-010092-uftc8inx 8733 9 molecular molecular JJ cord-010092-uftc8inx 8733 10 testing testing NN cord-010092-uftc8inx 8733 11 ( ( -LRB- cord-010092-uftc8inx 8733 12 Immucor Immucor NNP cord-010092-uftc8inx 8733 13 BioArray BioArray NNP cord-010092-uftc8inx 8733 14 RHCE RHCE NNP cord-010092-uftc8inx 8733 15 and and CC cord-010092-uftc8inx 8733 16 RHD RHD NNP cord-010092-uftc8inx 8733 17 BeadChip BeadChip NNP cord-010092-uftc8inx 8733 18 assays assay NNS cord-010092-uftc8inx 8733 19 ) ) -RRB- cord-010092-uftc8inx 8733 20 at at IN cord-010092-uftc8inx 8733 21 the the DT cord-010092-uftc8inx 8733 22 Hellenic Hellenic NNP cord-010092-uftc8inx 8733 23 National National NNP cord-010092-uftc8inx 8733 24 Blood Blood NNP cord-010092-uftc8inx 8733 25 Transfusion Transfusion NNP cord-010092-uftc8inx 8733 26 Center Center NNP cord-010092-uftc8inx 8733 27 , , , cord-010092-uftc8inx 8733 28 in in IN cord-010092-uftc8inx 8733 29 case case NN cord-010092-uftc8inx 8733 30 of of IN cord-010092-uftc8inx 8733 31 remaining remain VBG cord-010092-uftc8inx 8733 32 uncertainty uncertainty NN cord-010092-uftc8inx 8733 33 . . . cord-010092-uftc8inx 8734 1 Results result NNS cord-010092-uftc8inx 8734 2 : : : cord-010092-uftc8inx 8735 1 We -PRON- PRP cord-010092-uftc8inx 8735 2 applied apply VBD cord-010092-uftc8inx 8735 3 the the DT cord-010092-uftc8inx 8735 4 above above JJ cord-010092-uftc8inx 8735 5 algorithm algorithm NN cord-010092-uftc8inx 8735 6 in in IN cord-010092-uftc8inx 8735 7 32 32 CD cord-010092-uftc8inx 8735 8 samples sample NNS cord-010092-uftc8inx 8735 9 : : : cord-010092-uftc8inx 8736 1 A a LS cord-010092-uftc8inx 8736 2 ) ) -RRB- cord-010092-uftc8inx 8737 1 By by IN cord-010092-uftc8inx 8737 2 using use VBG cord-010092-uftc8inx 8737 3 the the DT cord-010092-uftc8inx 8737 4 partial partial JJ cord-010092-uftc8inx 8737 5 D d NN cord-010092-uftc8inx 8737 6 kit kit NN cord-010092-uftc8inx 8737 7 , , , cord-010092-uftc8inx 8737 8 23 23 CD cord-010092-uftc8inx 8737 9 samples sample NNS cord-010092-uftc8inx 8737 10 were be VBD cord-010092-uftc8inx 8737 11 typed type VBN cord-010092-uftc8inx 8737 12 : : : cord-010092-uftc8inx 8737 13 Four four CD cord-010092-uftc8inx 8737 14 samples sample NNS cord-010092-uftc8inx 8737 15 were be VBD cord-010092-uftc8inx 8737 16 characterized characterize VBN cord-010092-uftc8inx 8737 17 as as IN cord-010092-uftc8inx 8737 18 " " `` cord-010092-uftc8inx 8737 19 partial partial JJ cord-010092-uftc8inx 8737 20 D d NN cord-010092-uftc8inx 8737 21 " " '' cord-010092-uftc8inx 8737 22 ( ( -LRB- cord-010092-uftc8inx 8737 23 3 3 CD cord-010092-uftc8inx 8737 24 DFR DFR NNP cord-010092-uftc8inx 8737 25 , , , cord-010092-uftc8inx 8737 26 1DIII 1diii CD cord-010092-uftc8inx 8737 27 ) ) -RRB- cord-010092-uftc8inx 8737 28 and and CC cord-010092-uftc8inx 8737 29 19 19 CD cord-010092-uftc8inx 8737 30 as as IN cord-010092-uftc8inx 8737 31 " " `` cord-010092-uftc8inx 8737 32 weak weak JJ cord-010092-uftc8inx 8737 33 D d NN cord-010092-uftc8inx 8737 34 " " '' cord-010092-uftc8inx 8737 35 . . . cord-010092-uftc8inx 8738 1 Four four CD cord-010092-uftc8inx 8738 2 of of IN cord-010092-uftc8inx 8738 3 the the DT cord-010092-uftc8inx 8738 4 weak weak JJ cord-010092-uftc8inx 8738 5 D d NN cord-010092-uftc8inx 8738 6 samples sample NNS cord-010092-uftc8inx 8738 7 ( ( -LRB- cord-010092-uftc8inx 8738 8 all all DT cord-010092-uftc8inx 8738 9 from from IN cord-010092-uftc8inx 8738 10 women woman NNS cord-010092-uftc8inx 8738 11 of of IN cord-010092-uftc8inx 8738 12 reproductive reproductive JJ cord-010092-uftc8inx 8738 13 age age NN cord-010092-uftc8inx 8738 14 ) ) -RRB- cord-010092-uftc8inx 8738 15 were be VBD cord-010092-uftc8inx 8738 16 confirmed confirm VBN cord-010092-uftc8inx 8738 17 by by IN cord-010092-uftc8inx 8738 18 molecular molecular JJ cord-010092-uftc8inx 8738 19 typing typing NN cord-010092-uftc8inx 8738 20 ( ( -LRB- cord-010092-uftc8inx 8738 21 " " `` cord-010092-uftc8inx 8738 22 Weak weak JJ cord-010092-uftc8inx 8738 23 D d NN cord-010092-uftc8inx 8738 24 type type NN cord-010092-uftc8inx 8738 25 1 1 CD cord-010092-uftc8inx 8738 26 " " '' cord-010092-uftc8inx 8738 27 three three CD cord-010092-uftc8inx 8738 28 samples sample NNS cord-010092-uftc8inx 8738 29 , , , cord-010092-uftc8inx 8738 30 " " `` cord-010092-uftc8inx 8738 31 Weak weak JJ cord-010092-uftc8inx 8738 32 D d NN cord-010092-uftc8inx 8738 33 type type NN cord-010092-uftc8inx 8738 34 4.0 4.0 CD cord-010092-uftc8inx 8738 35 or or CC cord-010092-uftc8inx 8738 36 4.3 4.3 CD cord-010092-uftc8inx 8738 37 " " `` cord-010092-uftc8inx 8738 38 one one CD cord-010092-uftc8inx 8738 39 sample sample NN cord-010092-uftc8inx 8738 40 ) ) -RRB- cord-010092-uftc8inx 8738 41 . . . cord-010092-uftc8inx 8739 1 B b NN cord-010092-uftc8inx 8739 2 ) ) -RRB- cord-010092-uftc8inx 8740 1 The the DT cord-010092-uftc8inx 8740 2 nine nine CD cord-010092-uftc8inx 8740 3 ( ( -LRB- cord-010092-uftc8inx 8740 4 9 9 CD cord-010092-uftc8inx 8740 5 ) ) -RRB- cord-010092-uftc8inx 8740 6 remaining remain VBG cord-010092-uftc8inx 8740 7 samples sample NNS cord-010092-uftc8inx 8740 8 that that WDT cord-010092-uftc8inx 8740 9 showed show VBD cord-010092-uftc8inx 8740 10 atypical atypical JJ cord-010092-uftc8inx 8740 11 serological serological JJ cord-010092-uftc8inx 8740 12 pattern pattern NN cord-010092-uftc8inx 8740 13 , , , cord-010092-uftc8inx 8740 14 were be VBD cord-010092-uftc8inx 8740 15 sent send VBN cord-010092-uftc8inx 8740 16 for for IN cord-010092-uftc8inx 8740 17 molecular molecular JJ cord-010092-uftc8inx 8740 18 testing testing NN cord-010092-uftc8inx 8740 19 , , , cord-010092-uftc8inx 8740 20 which which WDT cord-010092-uftc8inx 8740 21 characterized characterize VBD cord-010092-uftc8inx 8740 22 2 2 CD cord-010092-uftc8inx 8740 23 samples sample NNS cord-010092-uftc8inx 8740 24 as as IN cord-010092-uftc8inx 8740 25 " " `` cord-010092-uftc8inx 8740 26 Weak weak JJ cord-010092-uftc8inx 8740 27 D d NN cord-010092-uftc8inx 8740 28 type type NN cord-010092-uftc8inx 8740 29 1 1 CD cord-010092-uftc8inx 8740 30 " " '' cord-010092-uftc8inx 8740 31 , , , cord-010092-uftc8inx 8740 32 one one CD cord-010092-uftc8inx 8740 33 sample sample NN cord-010092-uftc8inx 8740 34 as as IN cord-010092-uftc8inx 8740 35 " " `` cord-010092-uftc8inx 8740 36 Weak weak JJ cord-010092-uftc8inx 8740 37 D d NN cord-010092-uftc8inx 8740 38 type type NN cord-010092-uftc8inx 8740 39 3 3 CD cord-010092-uftc8inx 8740 40 " " '' cord-010092-uftc8inx 8740 41 and and CC cord-010092-uftc8inx 8740 42 another another DT cord-010092-uftc8inx 8740 43 as as IN cord-010092-uftc8inx 8740 44 " " `` cord-010092-uftc8inx 8740 45 Weak weak JJ cord-010092-uftc8inx 8740 46 D d NN cord-010092-uftc8inx 8740 47 type type NN cord-010092-uftc8inx 8740 48 11 11 CD cord-010092-uftc8inx 8740 49 " " '' cord-010092-uftc8inx 8740 50 . . . cord-010092-uftc8inx 8741 1 Results result NNS cord-010092-uftc8inx 8741 2 are be VBP cord-010092-uftc8inx 8741 3 pending pende VBG cord-010092-uftc8inx 8741 4 for for IN cord-010092-uftc8inx 8741 5 5 5 CD cord-010092-uftc8inx 8741 6 samples sample NNS cord-010092-uftc8inx 8741 7 . . . cord-010092-uftc8inx 8742 1 Summary Summary NNP cord-010092-uftc8inx 8742 2 / / SYM cord-010092-uftc8inx 8742 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 8742 4 : : : cord-010092-uftc8inx 8743 1 In in IN cord-010092-uftc8inx 8743 2 our -PRON- PRP$ cord-010092-uftc8inx 8743 3 experience experience NN cord-010092-uftc8inx 8743 4 some some DT cord-010092-uftc8inx 8743 5 partial partial JJ cord-010092-uftc8inx 8743 6 RHDs rhd NNS cord-010092-uftc8inx 8743 7 may may MD cord-010092-uftc8inx 8743 8 be be VB cord-010092-uftc8inx 8743 9 mistyped mistype VBN cord-010092-uftc8inx 8743 10 as as IN cord-010092-uftc8inx 8743 11 RHD+ RHD+ NNP cord-010092-uftc8inx 8743 12 if if IN cord-010092-uftc8inx 8743 13 the the DT cord-010092-uftc8inx 8743 14 technologist technologist NN cord-010092-uftc8inx 8743 15 does do VBZ cord-010092-uftc8inx 8743 16 not not RB cord-010092-uftc8inx 8743 17 inspect inspect VB cord-010092-uftc8inx 8743 18 the the DT cord-010092-uftc8inx 8743 19 pattern pattern NN cord-010092-uftc8inx 8743 20 of of IN cord-010092-uftc8inx 8743 21 the the DT cord-010092-uftc8inx 8743 22 reactions reaction NNS cord-010092-uftc8inx 8743 23 and and CC cord-010092-uftc8inx 8743 24 only only RB cord-010092-uftc8inx 8743 25 takes take VBZ cord-010092-uftc8inx 8743 26 into into IN cord-010092-uftc8inx 8743 27 account account NN cord-010092-uftc8inx 8743 28 the the DT cord-010092-uftc8inx 8743 29 assignment assignment NN cord-010092-uftc8inx 8743 30 by by IN cord-010092-uftc8inx 8743 31 the the DT cord-010092-uftc8inx 8743 32 automatic automatic JJ cord-010092-uftc8inx 8743 33 analyzer analyzer NN cord-010092-uftc8inx 8743 34 as as IN cord-010092-uftc8inx 8743 35 D+ d+ NN cord-010092-uftc8inx 8743 36 or or CC cord-010092-uftc8inx 8743 37 D- d- NN cord-010092-uftc8inx 8743 38 . . . cord-010092-uftc8inx 8744 1 By by IN cord-010092-uftc8inx 8744 2 use use NN cord-010092-uftc8inx 8744 3 of of IN cord-010092-uftc8inx 8744 4 our -PRON- PRP$ cord-010092-uftc8inx 8744 5 algorithm algorithm NN cord-010092-uftc8inx 8744 6 , , , cord-010092-uftc8inx 8744 7 serological serological JJ cord-010092-uftc8inx 8744 8 characterization characterization NN cord-010092-uftc8inx 8744 9 was be VBD cord-010092-uftc8inx 8744 10 sufficient sufficient JJ cord-010092-uftc8inx 8744 11 to to TO cord-010092-uftc8inx 8744 12 distinguish distinguish VB cord-010092-uftc8inx 8744 13 between between IN cord-010092-uftc8inx 8744 14 weak weak JJ cord-010092-uftc8inx 8744 15 D d NN cord-010092-uftc8inx 8744 16 and and CC cord-010092-uftc8inx 8744 17 partial partial JJ cord-010092-uftc8inx 8744 18 D d NN cord-010092-uftc8inx 8744 19 in in IN cord-010092-uftc8inx 8744 20 68,75 68,75 CD cord-010092-uftc8inx 8744 21 % % NN cord-010092-uftc8inx 8744 22 of of IN cord-010092-uftc8inx 8744 23 cases case NNS cord-010092-uftc8inx 8744 24 . . . cord-010092-uftc8inx 8745 1 Molecular molecular JJ cord-010092-uftc8inx 8745 2 typing typing NN cord-010092-uftc8inx 8745 3 was be VBD cord-010092-uftc8inx 8745 4 necessary necessary JJ cord-010092-uftc8inx 8745 5 in in IN cord-010092-uftc8inx 8745 6 the the DT cord-010092-uftc8inx 8745 7 rest rest NN cord-010092-uftc8inx 8745 8 . . . cord-010092-uftc8inx 8746 1 The the DT cord-010092-uftc8inx 8746 2 integration integration NN cord-010092-uftc8inx 8746 3 of of IN cord-010092-uftc8inx 8746 4 molecular molecular JJ cord-010092-uftc8inx 8746 5 techniques technique NNS cord-010092-uftc8inx 8746 6 improves improve VBZ cord-010092-uftc8inx 8746 7 the the DT cord-010092-uftc8inx 8746 8 quality quality NN cord-010092-uftc8inx 8746 9 and and CC cord-010092-uftc8inx 8746 10 accuracy accuracy NN cord-010092-uftc8inx 8746 11 of of IN cord-010092-uftc8inx 8746 12 D d NN cord-010092-uftc8inx 8746 13 typing typing NN cord-010092-uftc8inx 8746 14 of of IN cord-010092-uftc8inx 8746 15 blood blood NN cord-010092-uftc8inx 8746 16 donors donor NNS cord-010092-uftc8inx 8746 17 . . . cord-010092-uftc8inx 8747 1 If if IN cord-010092-uftc8inx 8747 2 applied apply VBN cord-010092-uftc8inx 8747 3 to to IN cord-010092-uftc8inx 8747 4 patients patient NNS cord-010092-uftc8inx 8747 5 , , , cord-010092-uftc8inx 8747 6 it -PRON- PRP cord-010092-uftc8inx 8747 7 also also RB cord-010092-uftc8inx 8747 8 allows allow VBZ cord-010092-uftc8inx 8747 9 administration administration NN cord-010092-uftc8inx 8747 10 of of IN cord-010092-uftc8inx 8747 11 D D NNP cord-010092-uftc8inx 8747 12 positive positive JJ cord-010092-uftc8inx 8747 13 blood blood NN cord-010092-uftc8inx 8747 14 without without IN cord-010092-uftc8inx 8747 15 compromising compromise VBG cord-010092-uftc8inx 8747 16 safety safety NN cord-010092-uftc8inx 8747 17 to to IN cord-010092-uftc8inx 8747 18 those those DT cord-010092-uftc8inx 8747 19 carrying carry VBG cord-010092-uftc8inx 8747 20 prevalent prevalent JJ cord-010092-uftc8inx 8747 21 weak weak JJ cord-010092-uftc8inx 8747 22 D d NN cord-010092-uftc8inx 8747 23 types type NNS cord-010092-uftc8inx 8747 24 that that WDT cord-010092-uftc8inx 8747 25 have have VBP cord-010092-uftc8inx 8747 26 not not RB cord-010092-uftc8inx 8747 27 been be VBN cord-010092-uftc8inx 8747 28 reported report VBN cord-010092-uftc8inx 8747 29 to to TO cord-010092-uftc8inx 8747 30 produce produce VB cord-010092-uftc8inx 8747 31 anti anti NNP cord-010092-uftc8inx 8747 32 - - JJ cord-010092-uftc8inx 8747 33 D. D. NNP cord-010092-uftc8inx 8748 1 Furthermore furthermore RB cord-010092-uftc8inx 8748 2 , , , cord-010092-uftc8inx 8748 3 it -PRON- PRP cord-010092-uftc8inx 8748 4 permits permit VBZ cord-010092-uftc8inx 8748 5 withholding withhold VBG cord-010092-uftc8inx 8748 6 RhIG rhig NN cord-010092-uftc8inx 8748 7 in in IN cord-010092-uftc8inx 8748 8 case case NN cord-010092-uftc8inx 8748 9 of of IN cord-010092-uftc8inx 8748 10 pregnant pregnant JJ cord-010092-uftc8inx 8748 11 women woman NNS cord-010092-uftc8inx 8748 12 carrying carry VBG cord-010092-uftc8inx 8748 13 such such JJ cord-010092-uftc8inx 8748 14 weak weak JJ cord-010092-uftc8inx 8748 15 D d NN cord-010092-uftc8inx 8748 16 types type NNS cord-010092-uftc8inx 8748 17 . . . cord-010092-uftc8inx 8749 1 Background background NN cord-010092-uftc8inx 8749 2 : : : cord-010092-uftc8inx 8750 1 RhD RhD NNP cord-010092-uftc8inx 8750 2 antigen antigen NNP cord-010092-uftc8inx 8750 3 is be VBZ cord-010092-uftc8inx 8750 4 one one CD cord-010092-uftc8inx 8750 5 of of IN cord-010092-uftc8inx 8750 6 the the DT cord-010092-uftc8inx 8750 7 most most RBS cord-010092-uftc8inx 8750 8 clinically clinically RB cord-010092-uftc8inx 8750 9 significant significant JJ cord-010092-uftc8inx 8750 10 blood blood NN cord-010092-uftc8inx 8750 11 group group NN cord-010092-uftc8inx 8750 12 antigens antigen NNS cord-010092-uftc8inx 8750 13 . . . cord-010092-uftc8inx 8751 1 Except except IN cord-010092-uftc8inx 8751 2 D d NN cord-010092-uftc8inx 8751 3 positive positive JJ cord-010092-uftc8inx 8751 4 and and CC cord-010092-uftc8inx 8751 5 D d JJ cord-010092-uftc8inx 8751 6 negative negative JJ cord-010092-uftc8inx 8751 7 phenotypes phenotype NNS cord-010092-uftc8inx 8751 8 , , , cord-010092-uftc8inx 8751 9 there there EX cord-010092-uftc8inx 8751 10 are be VBP cord-010092-uftc8inx 8751 11 over over IN cord-010092-uftc8inx 8751 12 200 200 CD cord-010092-uftc8inx 8751 13 RhD rhd NN cord-010092-uftc8inx 8751 14 variants variant NNS cord-010092-uftc8inx 8751 15 , , , cord-010092-uftc8inx 8751 16 which which WDT cord-010092-uftc8inx 8751 17 represent represent VBP cord-010092-uftc8inx 8751 18 as as IN cord-010092-uftc8inx 8751 19 serologic serologic JJ cord-010092-uftc8inx 8751 20 weak weak JJ cord-010092-uftc8inx 8751 21 D d NN cord-010092-uftc8inx 8751 22 phenotypes phenotype NNS cord-010092-uftc8inx 8751 23 ( ( -LRB- cord-010092-uftc8inx 8751 24 swD swd NN cord-010092-uftc8inx 8751 25 ) ) -RRB- cord-010092-uftc8inx 8751 26 . . . cord-010092-uftc8inx 8752 1 Patients patient NNS cord-010092-uftc8inx 8752 2 with with IN cord-010092-uftc8inx 8752 3 certain certain JJ cord-010092-uftc8inx 8752 4 swD swD NNPS cord-010092-uftc8inx 8752 5 can can MD cord-010092-uftc8inx 8752 6 make make VB cord-010092-uftc8inx 8752 7 anti anti JJ cord-010092-uftc8inx 8752 8 - - JJ cord-010092-uftc8inx 8752 9 D d JJ cord-010092-uftc8inx 8752 10 alloantibodies alloantibody NNS cord-010092-uftc8inx 8752 11 . . . cord-010092-uftc8inx 8753 1 By by IN cord-010092-uftc8inx 8753 2 serology serology NN cord-010092-uftc8inx 8753 3 testing testing NN cord-010092-uftc8inx 8753 4 it -PRON- PRP cord-010092-uftc8inx 8753 5 is be VBZ cord-010092-uftc8inx 8753 6 not not RB cord-010092-uftc8inx 8753 7 possible possible JJ cord-010092-uftc8inx 8753 8 to to TO cord-010092-uftc8inx 8753 9 clearly clearly RB cord-010092-uftc8inx 8753 10 distinguish distinguish VB cord-010092-uftc8inx 8753 11 among among IN cord-010092-uftc8inx 8753 12 different different JJ cord-010092-uftc8inx 8753 13 swD. swd. NN cord-010092-uftc8inx 8754 1 In in IN cord-010092-uftc8inx 8754 2 Croatian Croatian NNP cord-010092-uftc8inx 8754 3 Institute Institute NNP cord-010092-uftc8inx 8754 4 of of IN cord-010092-uftc8inx 8754 5 Transfusion Transfusion NNP cord-010092-uftc8inx 8754 6 Medicine Medicine NNP cord-010092-uftc8inx 8754 7 ( ( -LRB- cord-010092-uftc8inx 8754 8 CITM CITM NNP cord-010092-uftc8inx 8754 9 ) ) -RRB- cord-010092-uftc8inx 8754 10 patients patient NNS cord-010092-uftc8inx 8754 11 and and CC cord-010092-uftc8inx 8754 12 pregnant pregnant JJ cord-010092-uftc8inx 8754 13 females female NNS cord-010092-uftc8inx 8754 14 with with IN cord-010092-uftc8inx 8754 15 swD swD NNS cord-010092-uftc8inx 8754 16 are be VBP cord-010092-uftc8inx 8754 17 mostly mostly RB cord-010092-uftc8inx 8754 18 reported report VBN cord-010092-uftc8inx 8754 19 as as IN cord-010092-uftc8inx 8754 20 RhD rhd NN cord-010092-uftc8inx 8754 21 negative negative JJ cord-010092-uftc8inx 8754 22 and and CC cord-010092-uftc8inx 8754 23 generally generally RB cord-010092-uftc8inx 8754 24 did do VBD cord-010092-uftc8inx 8754 25 not not RB cord-010092-uftc8inx 8754 26 refer refer VB cord-010092-uftc8inx 8754 27 for for IN cord-010092-uftc8inx 8754 28 confirmation confirmation NN cord-010092-uftc8inx 8754 29 , , , cord-010092-uftc8inx 8754 30 because because IN cord-010092-uftc8inx 8754 31 molecular molecular JJ cord-010092-uftc8inx 8754 32 testing testing NN cord-010092-uftc8inx 8754 33 was be VBD cord-010092-uftc8inx 8754 34 not not RB cord-010092-uftc8inx 8754 35 part part NN cord-010092-uftc8inx 8754 36 of of IN cord-010092-uftc8inx 8754 37 the the DT cord-010092-uftc8inx 8754 38 algorithm algorithm NN cord-010092-uftc8inx 8754 39 . . . cord-010092-uftc8inx 8755 1 That that DT cord-010092-uftc8inx 8755 2 remains remain VBZ cord-010092-uftc8inx 8755 3 the the DT cord-010092-uftc8inx 8755 4 risk risk NN cord-010092-uftc8inx 8755 5 of of IN cord-010092-uftc8inx 8755 6 shortages shortage NNS cord-010092-uftc8inx 8755 7 of of IN cord-010092-uftc8inx 8755 8 RhD RhD NNP cord-010092-uftc8inx 8755 9 negative negative JJ cord-010092-uftc8inx 8755 10 blood blood NN cord-010092-uftc8inx 8755 11 and and CC cord-010092-uftc8inx 8755 12 overuse overuse NN cord-010092-uftc8inx 8755 13 of of IN cord-010092-uftc8inx 8755 14 anti anti JJ cord-010092-uftc8inx 8755 15 - - JJ cord-010092-uftc8inx 8755 16 D d JJ cord-010092-uftc8inx 8755 17 immunoprophylaxis immunoprophylaxis NN cord-010092-uftc8inx 8755 18 for for IN cord-010092-uftc8inx 8755 19 pregnant pregnant JJ cord-010092-uftc8inx 8755 20 females female NNS cord-010092-uftc8inx 8755 21 . . . cord-010092-uftc8inx 8756 1 According accord VBG cord-010092-uftc8inx 8756 2 to to IN cord-010092-uftc8inx 8756 3 UK UK NNP cord-010092-uftc8inx 8756 4 Guidelines Guidelines NNPS cord-010092-uftc8inx 8756 5 patients patient NNS cord-010092-uftc8inx 8756 6 with with IN cord-010092-uftc8inx 8756 7 swD swD NNPS cord-010092-uftc8inx 8756 8 who who WP cord-010092-uftc8inx 8756 9 are be VBP cord-010092-uftc8inx 8756 10 likely likely JJ cord-010092-uftc8inx 8756 11 to to TO cord-010092-uftc8inx 8756 12 require require VB cord-010092-uftc8inx 8756 13 chronic chronic JJ cord-010092-uftc8inx 8756 14 transfusion transfusion NN cord-010092-uftc8inx 8756 15 support support NN cord-010092-uftc8inx 8756 16 and and CC cord-010092-uftc8inx 8756 17 females female NNS cord-010092-uftc8inx 8756 18 ≤ ≤ NNS cord-010092-uftc8inx 8756 19 50 50 CD cord-010092-uftc8inx 8756 20 years year NNS cord-010092-uftc8inx 8756 21 are be VBP cord-010092-uftc8inx 8756 22 treated treat VBN cord-010092-uftc8inx 8756 23 as as IN cord-010092-uftc8inx 8756 24 D D NNP cord-010092-uftc8inx 8756 25 negative negative JJ cord-010092-uftc8inx 8756 26 and and CC cord-010092-uftc8inx 8756 27 refer refer VBP cord-010092-uftc8inx 8756 28 for for IN cord-010092-uftc8inx 8756 29 confirmation confirmation NN cord-010092-uftc8inx 8756 30 of of IN cord-010092-uftc8inx 8756 31 D D NNP cord-010092-uftc8inx 8756 32 type type NN cord-010092-uftc8inx 8756 33 . . . cord-010092-uftc8inx 8757 1 People People NNS cord-010092-uftc8inx 8757 2 who who WP cord-010092-uftc8inx 8757 3 are be VBP cord-010092-uftc8inx 8757 4 RHD RHD NNP cord-010092-uftc8inx 8757 5 genotyped genotype VBN cord-010092-uftc8inx 8757 6 as as IN cord-010092-uftc8inx 8757 7 weak weak JJ cord-010092-uftc8inx 8757 8 D d NN cord-010092-uftc8inx 8757 9 type type NN cord-010092-uftc8inx 8757 10 1 1 CD cord-010092-uftc8inx 8757 11 , , , cord-010092-uftc8inx 8757 12 2 2 CD cord-010092-uftc8inx 8757 13 or or CC cord-010092-uftc8inx 8757 14 3 3 CD cord-010092-uftc8inx 8757 15 are be VBP cord-010092-uftc8inx 8757 16 not not RB cord-010092-uftc8inx 8757 17 susceptible susceptible JJ cord-010092-uftc8inx 8757 18 for for IN cord-010092-uftc8inx 8757 19 RhD RhD NNP cord-010092-uftc8inx 8757 20 alloimmunisation alloimmunisation NNP cord-010092-uftc8inx 8757 21 . . . cord-010092-uftc8inx 8758 1 One one CD cord-010092-uftc8inx 8758 2 study study NN cord-010092-uftc8inx 8758 3 showed show VBD cord-010092-uftc8inx 8758 4 that that IN cord-010092-uftc8inx 8758 5 in in IN cord-010092-uftc8inx 8758 6 Croatian croatian JJ cord-010092-uftc8inx 8758 7 population population NN cord-010092-uftc8inx 8758 8 the the DT cord-010092-uftc8inx 8758 9 most most RBS cord-010092-uftc8inx 8758 10 frequent frequent JJ cord-010092-uftc8inx 8758 11 variants variant NNS cord-010092-uftc8inx 8758 12 are be VBP cord-010092-uftc8inx 8758 13 weak weak JJ cord-010092-uftc8inx 8758 14 D d NN cord-010092-uftc8inx 8758 15 type type NN cord-010092-uftc8inx 8758 16 1 1 CD cord-010092-uftc8inx 8758 17 , , , cord-010092-uftc8inx 8758 18 2 2 CD cord-010092-uftc8inx 8758 19 and and CC cord-010092-uftc8inx 8758 20 3 3 CD cord-010092-uftc8inx 8758 21 . . . cord-010092-uftc8inx 8759 1 Aims aim VBZ cord-010092-uftc8inx 8759 2 : : : cord-010092-uftc8inx 8760 1 The the DT cord-010092-uftc8inx 8760 2 aim aim NN cord-010092-uftc8inx 8760 3 of of IN cord-010092-uftc8inx 8760 4 this this DT cord-010092-uftc8inx 8760 5 study study NN cord-010092-uftc8inx 8760 6 is be VBZ cord-010092-uftc8inx 8760 7 to to TO cord-010092-uftc8inx 8760 8 estimate estimate VB cord-010092-uftc8inx 8760 9 the the DT cord-010092-uftc8inx 8760 10 prevalence prevalence NN cord-010092-uftc8inx 8760 11 of of IN cord-010092-uftc8inx 8760 12 swD swD NNPS cord-010092-uftc8inx 8760 13 in in IN cord-010092-uftc8inx 8760 14 patients patient NNS cord-010092-uftc8inx 8760 15 and and CC cord-010092-uftc8inx 8760 16 pregnant pregnant JJ cord-010092-uftc8inx 8760 17 females female NNS cord-010092-uftc8inx 8760 18 and and CC cord-010092-uftc8inx 8760 19 to to TO cord-010092-uftc8inx 8760 20 find find VB cord-010092-uftc8inx 8760 21 out out RP cord-010092-uftc8inx 8760 22 serologic serologic JJ cord-010092-uftc8inx 8760 23 and and CC cord-010092-uftc8inx 8760 24 molecular molecular JJ cord-010092-uftc8inx 8760 25 characteristics characteristic NNS cord-010092-uftc8inx 8760 26 of of IN cord-010092-uftc8inx 8760 27 swD swD NNP cord-010092-uftc8inx 8760 28 referred refer VBN cord-010092-uftc8inx 8760 29 for for IN cord-010092-uftc8inx 8760 30 confirmation confirmation NN cord-010092-uftc8inx 8760 31 . . . cord-010092-uftc8inx 8761 1 Methods method NNS cord-010092-uftc8inx 8761 2 : : : cord-010092-uftc8inx 8761 3 From from IN cord-010092-uftc8inx 8761 4 2013/01/01 2013/01/01 CD cord-010092-uftc8inx 8761 5 to to IN cord-010092-uftc8inx 8761 6 2018/10/01 2018/10/01 CD cord-010092-uftc8inx 8761 7 we -PRON- PRP cord-010092-uftc8inx 8761 8 analysed analyse VBD cord-010092-uftc8inx 8761 9 119.845 119.845 CD cord-010092-uftc8inx 8761 10 samples sample NNS cord-010092-uftc8inx 8761 11 of of IN cord-010092-uftc8inx 8761 12 patients patient NNS cord-010092-uftc8inx 8761 13 and and CC cord-010092-uftc8inx 8761 14 pregnant pregnant JJ cord-010092-uftc8inx 8761 15 females female NNS cord-010092-uftc8inx 8761 16 . . . cord-010092-uftc8inx 8762 1 RhD RhD NNP cord-010092-uftc8inx 8762 2 typing typing NN cord-010092-uftc8inx 8762 3 was be VBD cord-010092-uftc8inx 8762 4 performed perform VBN cord-010092-uftc8inx 8762 5 by by IN cord-010092-uftc8inx 8762 6 anti anti JJ cord-010092-uftc8inx 8762 7 - - JJ cord-010092-uftc8inx 8762 8 D d JJ cord-010092-uftc8inx 8762 9 IgM IgM NNP cord-010092-uftc8inx 8762 10 monoclonal monoclonal JJ cord-010092-uftc8inx 8762 11 reagents reagent NNS cord-010092-uftc8inx 8762 12 in in IN cord-010092-uftc8inx 8762 13 direct direct JJ cord-010092-uftc8inx 8762 14 agglutination agglutination NN cord-010092-uftc8inx 8762 15 micromethod micromethod NN cord-010092-uftc8inx 8762 16 on on IN cord-010092-uftc8inx 8762 17 TANGO TANGO NNP cord-010092-uftc8inx 8763 1 ( ( -LRB- cord-010092-uftc8inx 8763 2 BS232 bs232 RB cord-010092-uftc8inx 8763 3 , , , cord-010092-uftc8inx 8763 4 BS226 bs226 NN cord-010092-uftc8inx 8763 5 ) ) -RRB- cord-010092-uftc8inx 8764 1 ( ( -LRB- cord-010092-uftc8inx 8764 2 BioRad BioRad NNP cord-010092-uftc8inx 8764 3 , , , cord-010092-uftc8inx 8764 4 Dreieich Dreieich NNP cord-010092-uftc8inx 8764 5 , , , cord-010092-uftc8inx 8764 6 Germany Germany NNP cord-010092-uftc8inx 8764 7 ) ) -RRB- cord-010092-uftc8inx 8764 8 , , , cord-010092-uftc8inx 8764 9 Swing Swing NNP cord-010092-uftc8inx 8764 10 Maestro Maestro NNP cord-010092-uftc8inx 8764 11 [ [ -LRB- cord-010092-uftc8inx 8764 12 LMH LMH NNP cord-010092-uftc8inx 8764 13 59/20 59/20 CD cord-010092-uftc8inx 8764 14 ( ( -LRB- cord-010092-uftc8inx 8764 15 LDM3 LDM3 NNP cord-010092-uftc8inx 8764 16 ) ) -RRB- cord-010092-uftc8inx 8764 17 + + SYM cord-010092-uftc8inx 8764 18 175 175 CD cord-010092-uftc8inx 8764 19 - - SYM cord-010092-uftc8inx 8764 20 2 2 CD cord-010092-uftc8inx 8764 21 and and CC cord-010092-uftc8inx 8764 22 TH-28 TH-28 NNP cord-010092-uftc8inx 8764 23 + + CC cord-010092-uftc8inx 8764 24 RUM-1 rum-1 NN cord-010092-uftc8inx 8764 25 + + CC cord-010092-uftc8inx 8764 26 LDM1 ldm1 NN cord-010092-uftc8inx 8764 27 ] ] -RRB- cord-010092-uftc8inx 8764 28 and and CC cord-010092-uftc8inx 8764 29 IH-1000 IH-1000 VBZ cord-010092-uftc8inx 8764 30 [ [ -LRB- cord-010092-uftc8inx 8764 31 LMH LMH NNP cord-010092-uftc8inx 8764 32 59/20 59/20 CD cord-010092-uftc8inx 8764 33 ( ( -LRB- cord-010092-uftc8inx 8764 34 LDM3 LDM3 NNP cord-010092-uftc8inx 8764 35 ) ) -RRB- cord-010092-uftc8inx 8764 36 + + SYM cord-010092-uftc8inx 8764 37 175 175 CD cord-010092-uftc8inx 8764 38 - - SYM cord-010092-uftc8inx 8764 39 2 2 CD cord-010092-uftc8inx 8764 40 ] ] -RRB- cord-010092-uftc8inx 8764 41 ( ( -LRB- cord-010092-uftc8inx 8764 42 ID ID NNP cord-010092-uftc8inx 8764 43 - - HYPH cord-010092-uftc8inx 8764 44 Card Card NNP cord-010092-uftc8inx 8764 45 , , , cord-010092-uftc8inx 8764 46 BioRad BioRad NNP cord-010092-uftc8inx 8764 47 , , , cord-010092-uftc8inx 8764 48 Cressier Cressier NNP cord-010092-uftc8inx 8764 49 , , , cord-010092-uftc8inx 8764 50 Switzerland Switzerland NNP cord-010092-uftc8inx 8764 51 ) ) -RRB- cord-010092-uftc8inx 8764 52 . . . cord-010092-uftc8inx 8765 1 Cut cut VB cord-010092-uftc8inx 8765 2 - - HYPH cord-010092-uftc8inx 8765 3 off off RP cord-010092-uftc8inx 8765 4 value value NN cord-010092-uftc8inx 8765 5 for for IN cord-010092-uftc8inx 8765 6 TANGO TANGO NNP cord-010092-uftc8inx 8765 7 was be VBD cord-010092-uftc8inx 8765 8 determined determine VBN cord-010092-uftc8inx 8765 9 as as IN cord-010092-uftc8inx 8765 10 + + CD cord-010092-uftc8inx 8765 11 + + CC cord-010092-uftc8inx 8765 12 and and CC cord-010092-uftc8inx 8765 13 for for IN cord-010092-uftc8inx 8765 14 gel gel NN cord-010092-uftc8inx 8765 15 microtyping microtyping NN cord-010092-uftc8inx 8765 16 as as IN cord-010092-uftc8inx 8766 1 + + CC cord-010092-uftc8inx 8767 1 + + CC cord-010092-uftc8inx 8768 1 + + UH cord-010092-uftc8inx 8768 2 . . . cord-010092-uftc8inx 8769 1 The the DT cord-010092-uftc8inx 8769 2 samples sample NNS cord-010092-uftc8inx 8769 3 with with IN cord-010092-uftc8inx 8769 4 results result NNS cord-010092-uftc8inx 8769 5 below below IN cord-010092-uftc8inx 8769 6 the the DT cord-010092-uftc8inx 8769 7 cut cut NN cord-010092-uftc8inx 8769 8 - - HYPH cord-010092-uftc8inx 8769 9 off off NN cord-010092-uftc8inx 8769 10 were be VBD cord-010092-uftc8inx 8769 11 reported report VBN cord-010092-uftc8inx 8769 12 and and CC cord-010092-uftc8inx 8769 13 treated treat VBN cord-010092-uftc8inx 8769 14 as as IN cord-010092-uftc8inx 8769 15 RhD rhd NN cord-010092-uftc8inx 8769 16 negative negative JJ cord-010092-uftc8inx 8769 17 , , , cord-010092-uftc8inx 8769 18 all all RB cord-010092-uftc8inx 8769 19 except except IN cord-010092-uftc8inx 8769 20 those those DT cord-010092-uftc8inx 8769 21 which which WDT cord-010092-uftc8inx 8769 22 gave give VBD cord-010092-uftc8inx 8769 23 discrepant discrepant JJ cord-010092-uftc8inx 8769 24 results result NNS cord-010092-uftc8inx 8769 25 at at IN cord-010092-uftc8inx 8769 26 current current JJ cord-010092-uftc8inx 8769 27 testing testing NN cord-010092-uftc8inx 8769 28 or or CC cord-010092-uftc8inx 8769 29 with with IN cord-010092-uftc8inx 8769 30 historical historical JJ cord-010092-uftc8inx 8769 31 data datum NNS cord-010092-uftc8inx 8769 32 . . . cord-010092-uftc8inx 8770 1 These these DT cord-010092-uftc8inx 8770 2 were be VBD cord-010092-uftc8inx 8770 3 sent send VBN cord-010092-uftc8inx 8770 4 to to IN cord-010092-uftc8inx 8770 5 RHD RHD NNP cord-010092-uftc8inx 8770 6 genotyping genotyping NN cord-010092-uftc8inx 8770 7 for for IN cord-010092-uftc8inx 8770 8 confirmation confirmation NN cord-010092-uftc8inx 8770 9 . . . cord-010092-uftc8inx 8771 1 DNA dna NN cord-010092-uftc8inx 8771 2 extraction extraction NN cord-010092-uftc8inx 8771 3 was be VBD cord-010092-uftc8inx 8771 4 done do VBN cord-010092-uftc8inx 8771 5 by by IN cord-010092-uftc8inx 8771 6 QIAamp QIAamp NNP cord-010092-uftc8inx 8771 7 Blood Blood NNP cord-010092-uftc8inx 8771 8 Mini Mini NNP cord-010092-uftc8inx 8771 9 kit kit NN cord-010092-uftc8inx 8771 10 ( ( -LRB- cord-010092-uftc8inx 8771 11 Qiagen Qiagen NNP cord-010092-uftc8inx 8771 12 , , , cord-010092-uftc8inx 8771 13 Hilden Hilden NNP cord-010092-uftc8inx 8771 14 , , , cord-010092-uftc8inx 8771 15 Germany Germany NNP cord-010092-uftc8inx 8771 16 ) ) -RRB- cord-010092-uftc8inx 8771 17 and and CC cord-010092-uftc8inx 8771 18 RHD RHD NNP cord-010092-uftc8inx 8771 19 genotyping genotyping NN cord-010092-uftc8inx 8771 20 by by IN cord-010092-uftc8inx 8771 21 PCR PCR NNP cord-010092-uftc8inx 8771 22 - - HYPH cord-010092-uftc8inx 8771 23 SSP SSP NNP cord-010092-uftc8inx 8771 24 kits kit NNS cord-010092-uftc8inx 8772 1 Ready Ready NNP cord-010092-uftc8inx 8772 2 GeneWeak GeneWeak NNP cord-010092-uftc8inx 8772 3 D D NNP cord-010092-uftc8inx 8772 4 and and CC cord-010092-uftc8inx 8772 5 Ready Ready NNP cord-010092-uftc8inx 8772 6 GeneCDE GeneCDE . cord-010092-uftc8inx 8773 1 ( ( -LRB- cord-010092-uftc8inx 8773 2 Inno Inno NNP cord-010092-uftc8inx 8773 3 - - HYPH cord-010092-uftc8inx 8773 4 Train Train NNP cord-010092-uftc8inx 8773 5 , , , cord-010092-uftc8inx 8773 6 Kronberg Kronberg NNP cord-010092-uftc8inx 8773 7 i -PRON- PRP cord-010092-uftc8inx 8773 8 m be VBP cord-010092-uftc8inx 8773 9 Taunus Taunus NNP cord-010092-uftc8inx 8773 10 , , , cord-010092-uftc8inx 8773 11 Germany Germany NNP cord-010092-uftc8inx 8773 12 ) ) -RRB- cord-010092-uftc8inx 8773 13 . . . cord-010092-uftc8inx 8774 1 Results result NNS cord-010092-uftc8inx 8774 2 : : : cord-010092-uftc8inx 8775 1 From from IN cord-010092-uftc8inx 8775 2 119.845 119.845 CD cord-010092-uftc8inx 8775 3 samples sample NNS cord-010092-uftc8inx 8775 4 300 300 CD cord-010092-uftc8inx 8775 5 ( ( -LRB- cord-010092-uftc8inx 8775 6 0,25 0,25 CD cord-010092-uftc8inx 8775 7 % % NN cord-010092-uftc8inx 8775 8 ) ) -RRB- cord-010092-uftc8inx 8775 9 were be VBD cord-010092-uftc8inx 8775 10 swD. swD. VBN cord-010092-uftc8inx 8775 11 71/300 71/300 CD cord-010092-uftc8inx 8775 12 ( ( -LRB- cord-010092-uftc8inx 8775 13 24 24 CD cord-010092-uftc8inx 8775 14 % % NN cord-010092-uftc8inx 8775 15 ) ) -RRB- cord-010092-uftc8inx 8775 16 were be VBD cord-010092-uftc8inx 8775 17 referred refer VBN cord-010092-uftc8inx 8775 18 to to IN cord-010092-uftc8inx 8775 19 RHD RHD NNP cord-010092-uftc8inx 8775 20 genotyping genotyping NN cord-010092-uftc8inx 8775 21 . . . cord-010092-uftc8inx 8776 1 55/71 55/71 CD cord-010092-uftc8inx 8776 2 ( ( -LRB- cord-010092-uftc8inx 8776 3 77 77 CD cord-010092-uftc8inx 8776 4 % % NN cord-010092-uftc8inx 8776 5 ) ) -RRB- cord-010092-uftc8inx 8777 1 samples sample NNS cord-010092-uftc8inx 8777 2 were be VBD cord-010092-uftc8inx 8777 3 weak weak JJ cord-010092-uftc8inx 8777 4 D d NN cord-010092-uftc8inx 8777 5 type type NN cord-010092-uftc8inx 8777 6 1 1 CD cord-010092-uftc8inx 8777 7 , , , cord-010092-uftc8inx 8777 8 2 2 CD cord-010092-uftc8inx 8777 9 or or CC cord-010092-uftc8inx 8777 10 3 3 CD cord-010092-uftc8inx 8777 11 , , , cord-010092-uftc8inx 8777 12 while while IN cord-010092-uftc8inx 8777 13 16/71 16/71 CD cord-010092-uftc8inx 8777 14 ( ( -LRB- cord-010092-uftc8inx 8777 15 23 23 CD cord-010092-uftc8inx 8777 16 % % NN cord-010092-uftc8inx 8777 17 ) ) -RRB- cord-010092-uftc8inx 8777 18 were be VBD cord-010092-uftc8inx 8777 19 weak weak JJ cord-010092-uftc8inx 8777 20 D d NN cord-010092-uftc8inx 8777 21 type type NN cord-010092-uftc8inx 8777 22 14 14 CD cord-010092-uftc8inx 8777 23 and and CC cord-010092-uftc8inx 8777 24 partial partial JJ cord-010092-uftc8inx 8777 25 D d NN cord-010092-uftc8inx 8777 26 variants variant NNS cord-010092-uftc8inx 8778 1 VII VII NNP cord-010092-uftc8inx 8778 2 and and CC cord-010092-uftc8inx 8778 3 Va. Virginia NNP cord-010092-uftc8inx 8778 4 Serologic Serologic NNP cord-010092-uftc8inx 8778 5 reactions reaction NNS cord-010092-uftc8inx 8778 6 with with IN cord-010092-uftc8inx 8778 7 monoclonal monoclonal JJ cord-010092-uftc8inx 8778 8 IgM IgM NNP cord-010092-uftc8inx 8778 9 anti anti JJ cord-010092-uftc8inx 8778 10 - - JJ cord-010092-uftc8inx 8778 11 D d JJ cord-010092-uftc8inx 8778 12 reagents reagent NNS cord-010092-uftc8inx 8778 13 showed show VBD cord-010092-uftc8inx 8778 14 different different JJ cord-010092-uftc8inx 8778 15 pattern pattern NN cord-010092-uftc8inx 8778 16 for for IN cord-010092-uftc8inx 8778 17 weak weak JJ cord-010092-uftc8inx 8778 18 D d NN cord-010092-uftc8inx 8778 19 types type NNS cord-010092-uftc8inx 8778 20 1 1 CD cord-010092-uftc8inx 8778 21 , , , cord-010092-uftc8inx 8778 22 2 2 CD cord-010092-uftc8inx 8778 23 and and CC cord-010092-uftc8inx 8778 24 3 3 CD cord-010092-uftc8inx 8778 25 . . . cord-010092-uftc8inx 8779 1 Clearly clearly RB cord-010092-uftc8inx 8779 2 negative negative JJ cord-010092-uftc8inx 8779 3 serologic serologic JJ cord-010092-uftc8inx 8779 4 reactions reaction NNS cord-010092-uftc8inx 8779 5 were be VBD cord-010092-uftc8inx 8779 6 given give VBN cord-010092-uftc8inx 8779 7 in in IN cord-010092-uftc8inx 8779 8 27/29 27/29 CD cord-010092-uftc8inx 8779 9 samples sample NNS cord-010092-uftc8inx 8779 10 with with IN cord-010092-uftc8inx 8779 11 BS BS NNP cord-010092-uftc8inx 8779 12 226 226 CD cord-010092-uftc8inx 8779 13 and and CC cord-010092-uftc8inx 8779 14 BS BS NNP cord-010092-uftc8inx 8779 15 232 232 CD cord-010092-uftc8inx 8779 16 , , , cord-010092-uftc8inx 8779 17 in in IN cord-010092-uftc8inx 8779 18 30/33 30/33 CD cord-010092-uftc8inx 8779 19 samples sample NNS cord-010092-uftc8inx 8779 20 with with IN cord-010092-uftc8inx 8779 21 LMH LMH NNP cord-010092-uftc8inx 8779 22 59/20 59/20 CD cord-010092-uftc8inx 8779 23 ( ( -LRB- cord-010092-uftc8inx 8779 24 LDM3 LDM3 NNP cord-010092-uftc8inx 8779 25 ) ) -RRB- cord-010092-uftc8inx 8779 26 + + SYM cord-010092-uftc8inx 8779 27 175 175 CD cord-010092-uftc8inx 8779 28 - - SYM cord-010092-uftc8inx 8779 29 2 2 CD cord-010092-uftc8inx 8779 30 and and CC cord-010092-uftc8inx 8779 31 in in IN cord-010092-uftc8inx 8779 32 18/39 18/39 CD cord-010092-uftc8inx 8779 33 samples sample NNS cord-010092-uftc8inx 8779 34 with with IN cord-010092-uftc8inx 8780 1 TH-28 TH-28 NNP cord-010092-uftc8inx 8780 2 + + CC cord-010092-uftc8inx 8780 3 RUM-1 rum-1 NN cord-010092-uftc8inx 8780 4 + + CC cord-010092-uftc8inx 8780 5 LDM1 LDM1 NNP cord-010092-uftc8inx 8780 6 . . . cord-010092-uftc8inx 8781 1 Summary Summary NNP cord-010092-uftc8inx 8781 2 / / SYM cord-010092-uftc8inx 8781 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 8781 4 : : : cord-010092-uftc8inx 8782 1 The the DT cord-010092-uftc8inx 8782 2 prevalence prevalence NN cord-010092-uftc8inx 8782 3 of of IN cord-010092-uftc8inx 8782 4 swD swD NNPS cord-010092-uftc8inx 8782 5 in in IN cord-010092-uftc8inx 8782 6 this this DT cord-010092-uftc8inx 8782 7 study study NN cord-010092-uftc8inx 8782 8 is be VBZ cord-010092-uftc8inx 8782 9 rather rather RB cord-010092-uftc8inx 8782 10 low low JJ cord-010092-uftc8inx 8782 11 ( ( -LRB- cord-010092-uftc8inx 8782 12 0,25 0,25 CD cord-010092-uftc8inx 8782 13 % % NN cord-010092-uftc8inx 8782 14 ) ) -RRB- cord-010092-uftc8inx 8782 15 . . . cord-010092-uftc8inx 8783 1 After after IN cord-010092-uftc8inx 8783 2 RHD RHD NNP cord-010092-uftc8inx 8783 3 genotyping genotype VBG cord-010092-uftc8inx 8783 4 77 77 CD cord-010092-uftc8inx 8783 5 % % NN cord-010092-uftc8inx 8783 6 of of IN cord-010092-uftc8inx 8783 7 referred refer VBN cord-010092-uftc8inx 8783 8 samples sample NNS cord-010092-uftc8inx 8783 9 were be VBD cord-010092-uftc8inx 8783 10 finally finally RB cord-010092-uftc8inx 8783 11 reported report VBN cord-010092-uftc8inx 8783 12 as as IN cord-010092-uftc8inx 8783 13 D D NNP cord-010092-uftc8inx 8783 14 positive positive JJ cord-010092-uftc8inx 8783 15 . . . cord-010092-uftc8inx 8784 1 Serologic Serologic NNP cord-010092-uftc8inx 8784 2 determination determination NN cord-010092-uftc8inx 8784 3 of of IN cord-010092-uftc8inx 8784 4 D d NN cord-010092-uftc8inx 8784 5 variants variant NNS cord-010092-uftc8inx 8784 6 is be VBZ cord-010092-uftc8inx 8784 7 inconsistent inconsistent JJ cord-010092-uftc8inx 8784 8 and and CC cord-010092-uftc8inx 8784 9 only only JJ cord-010092-uftc8inx 8784 10 RHD rhd NN cord-010092-uftc8inx 8784 11 genotyping genotyping NN cord-010092-uftc8inx 8784 12 can can MD cord-010092-uftc8inx 8784 13 resolve resolve VB cord-010092-uftc8inx 8784 14 RhD rhd NN cord-010092-uftc8inx 8784 15 status status NN cord-010092-uftc8inx 8784 16 in in IN cord-010092-uftc8inx 8784 17 swD. swd. NN cord-010092-uftc8inx 8784 18 To to TO cord-010092-uftc8inx 8784 19 define define VB cord-010092-uftc8inx 8784 20 the the DT cord-010092-uftc8inx 8784 21 permanent permanent JJ cord-010092-uftc8inx 8784 22 RhD rhd NN cord-010092-uftc8inx 8784 23 status status NN cord-010092-uftc8inx 8784 24 of of IN cord-010092-uftc8inx 8784 25 swD swD JJS cord-010092-uftc8inx 8784 26 female female NN cord-010092-uftc8inx 8784 27 of of IN cord-010092-uftc8inx 8784 28 childbearing childbeare VBG cord-010092-uftc8inx 8784 29 potential potential NN cord-010092-uftc8inx 8784 30 and and CC cord-010092-uftc8inx 8784 31 patients patient NNS cord-010092-uftc8inx 8784 32 who who WP cord-010092-uftc8inx 8784 33 are be VBP cord-010092-uftc8inx 8784 34 likely likely JJ cord-010092-uftc8inx 8784 35 to to TO cord-010092-uftc8inx 8784 36 be be VB cord-010092-uftc8inx 8784 37 chronically chronically RB cord-010092-uftc8inx 8784 38 transfused transfuse VBN cord-010092-uftc8inx 8784 39 we -PRON- PRP cord-010092-uftc8inx 8784 40 will will MD cord-010092-uftc8inx 8784 41 introduce introduce VB cord-010092-uftc8inx 8784 42 RHD RHD NNP cord-010092-uftc8inx 8784 43 genotyping genotyping NN cord-010092-uftc8inx 8784 44 in in IN cord-010092-uftc8inx 8784 45 the the DT cord-010092-uftc8inx 8784 46 new new JJ cord-010092-uftc8inx 8784 47 algorithm algorithm NN cord-010092-uftc8inx 8784 48 . . . cord-010092-uftc8inx 8785 1 Background background NN cord-010092-uftc8inx 8785 2 : : : cord-010092-uftc8inx 8786 1 Among among IN cord-010092-uftc8inx 8786 2 all all DT cord-010092-uftc8inx 8786 3 blood blood NN cord-010092-uftc8inx 8786 4 group group NN cord-010092-uftc8inx 8786 5 systems system NNS cord-010092-uftc8inx 8786 6 , , , cord-010092-uftc8inx 8786 7 the the DT cord-010092-uftc8inx 8786 8 antigens antigen NNS cord-010092-uftc8inx 8786 9 of of IN cord-010092-uftc8inx 8786 10 the the DT cord-010092-uftc8inx 8786 11 ABO ABO NNP cord-010092-uftc8inx 8786 12 system system NN cord-010092-uftc8inx 8786 13 are be VBP cord-010092-uftc8inx 8786 14 by by IN cord-010092-uftc8inx 8786 15 far far RB cord-010092-uftc8inx 8786 16 the the DT cord-010092-uftc8inx 8786 17 most most RBS cord-010092-uftc8inx 8786 18 clinically clinically RB cord-010092-uftc8inx 8786 19 significant significant JJ cord-010092-uftc8inx 8786 20 . . . cord-010092-uftc8inx 8787 1 Comes come VBZ cord-010092-uftc8inx 8787 2 second second JJ cord-010092-uftc8inx 8787 3 in in IN cord-010092-uftc8inx 8787 4 importance importance NN cord-010092-uftc8inx 8787 5 is be VBZ cord-010092-uftc8inx 8787 6 the the DT cord-010092-uftc8inx 8787 7 antigens antigen NNS cord-010092-uftc8inx 8787 8 of of IN cord-010092-uftc8inx 8787 9 the the DT cord-010092-uftc8inx 8787 10 Rh Rh NNP cord-010092-uftc8inx 8787 11 system system NN cord-010092-uftc8inx 8787 12 , , , cord-010092-uftc8inx 8787 13 which which WDT cord-010092-uftc8inx 8787 14 comprise comprise VBP cord-010092-uftc8inx 8787 15 D D NNP cord-010092-uftc8inx 8787 16 , , , cord-010092-uftc8inx 8787 17 C C NNP cord-010092-uftc8inx 8787 18 , , , cord-010092-uftc8inx 8787 19 E E NNP cord-010092-uftc8inx 8787 20 , , , cord-010092-uftc8inx 8787 21 c c NNP cord-010092-uftc8inx 8787 22 , , , cord-010092-uftc8inx 8787 23 and and CC cord-010092-uftc8inx 8787 24 e e LS cord-010092-uftc8inx 8787 25 antigens antigen NNS cord-010092-uftc8inx 8787 26 . . . cord-010092-uftc8inx 8788 1 Another another DT cord-010092-uftc8inx 8788 2 clinically clinically RB cord-010092-uftc8inx 8788 3 relevant relevant JJ cord-010092-uftc8inx 8788 4 antigen antigen NN cord-010092-uftc8inx 8788 5 is be VBZ cord-010092-uftc8inx 8788 6 the the DT cord-010092-uftc8inx 8788 7 K K NNP cord-010092-uftc8inx 8788 8 of of IN cord-010092-uftc8inx 8788 9 the the DT cord-010092-uftc8inx 8788 10 Kell Kell NNP cord-010092-uftc8inx 8788 11 blood blood NN cord-010092-uftc8inx 8788 12 group group NN cord-010092-uftc8inx 8788 13 system system NN cord-010092-uftc8inx 8788 14 , , , cord-010092-uftc8inx 8788 15 which which WDT cord-010092-uftc8inx 8788 16 is be VBZ cord-010092-uftc8inx 8788 17 known know VBN cord-010092-uftc8inx 8788 18 to to TO cord-010092-uftc8inx 8788 19 be be VB cord-010092-uftc8inx 8788 20 involved involve VBN cord-010092-uftc8inx 8788 21 in in IN cord-010092-uftc8inx 8788 22 both both DT cord-010092-uftc8inx 8788 23 HTR HTR NNP cord-010092-uftc8inx 8788 24 and and CC cord-010092-uftc8inx 8788 25 HDFN HDFN NNP cord-010092-uftc8inx 8788 26 . . . cord-010092-uftc8inx 8789 1 The the DT cord-010092-uftc8inx 8789 2 distribution distribution NN cord-010092-uftc8inx 8789 3 of of IN cord-010092-uftc8inx 8789 4 the the DT cord-010092-uftc8inx 8789 5 major major JJ cord-010092-uftc8inx 8789 6 blood blood NN cord-010092-uftc8inx 8789 7 group group NN cord-010092-uftc8inx 8789 8 antigens antigen NNS cord-010092-uftc8inx 8789 9 , , , cord-010092-uftc8inx 8789 10 such such JJ cord-010092-uftc8inx 8789 11 as as IN cord-010092-uftc8inx 8789 12 Rh Rh NNP cord-010092-uftc8inx 8789 13 , , , cord-010092-uftc8inx 8789 14 and and CC cord-010092-uftc8inx 8789 15 Kell Kell NNP cord-010092-uftc8inx 8789 16 , , , cord-010092-uftc8inx 8789 17 is be VBZ cord-010092-uftc8inx 8789 18 well well RB cord-010092-uftc8inx 8789 19 - - HYPH cord-010092-uftc8inx 8789 20 studied study VBN cord-010092-uftc8inx 8789 21 among among IN cord-010092-uftc8inx 8789 22 populations population NNS cord-010092-uftc8inx 8789 23 of of IN cord-010092-uftc8inx 8789 24 developing develop VBG cord-010092-uftc8inx 8789 25 countries country NNS cord-010092-uftc8inx 8789 26 . . . cord-010092-uftc8inx 8790 1 In in IN cord-010092-uftc8inx 8790 2 contrary contrary NN cord-010092-uftc8inx 8790 3 , , , cord-010092-uftc8inx 8790 4 a a DT cord-010092-uftc8inx 8790 5 relatively relatively RB cord-010092-uftc8inx 8790 6 few few JJ cord-010092-uftc8inx 8790 7 studies study NNS cord-010092-uftc8inx 8790 8 have have VBP cord-010092-uftc8inx 8790 9 addressed address VBN cord-010092-uftc8inx 8790 10 their -PRON- PRP$ cord-010092-uftc8inx 8790 11 frequencies frequency NNS cord-010092-uftc8inx 8790 12 in in IN cord-010092-uftc8inx 8790 13 Saudi saudi JJ cord-010092-uftc8inx 8790 14 Arabian arabian JJ cord-010092-uftc8inx 8790 15 population population NN cord-010092-uftc8inx 8791 1 This this DT cord-010092-uftc8inx 8791 2 is be VBZ cord-010092-uftc8inx 8791 3 also also RB cord-010092-uftc8inx 8791 4 the the DT cord-010092-uftc8inx 8791 5 case case NN cord-010092-uftc8inx 8791 6 in in IN cord-010092-uftc8inx 8791 7 Jazan Jazan NNP cord-010092-uftc8inx 8791 8 province province NN cord-010092-uftc8inx 8791 9 , , , cord-010092-uftc8inx 8791 10 where where WRB cord-010092-uftc8inx 8791 11 only only RB cord-010092-uftc8inx 8791 12 two two CD cord-010092-uftc8inx 8791 13 published publish VBN cord-010092-uftc8inx 8791 14 studies study NNS cord-010092-uftc8inx 8791 15 have have VBP cord-010092-uftc8inx 8791 16 analysed analyse VBN cord-010092-uftc8inx 8791 17 the the DT cord-010092-uftc8inx 8791 18 prevalence prevalence NN cord-010092-uftc8inx 8791 19 of of IN cord-010092-uftc8inx 8791 20 ABO ABO NNP cord-010092-uftc8inx 8791 21 and and CC cord-010092-uftc8inx 8791 22 D d NN cord-010092-uftc8inx 8791 23 antigens antigen NNS cord-010092-uftc8inx 8791 24 , , , cord-010092-uftc8inx 8791 25 while while IN cord-010092-uftc8inx 8791 26 the the DT cord-010092-uftc8inx 8791 27 frequency frequency NN cord-010092-uftc8inx 8791 28 of of IN cord-010092-uftc8inx 8791 29 other other JJ cord-010092-uftc8inx 8791 30 clinically clinically RB cord-010092-uftc8inx 8791 31 important important JJ cord-010092-uftc8inx 8791 32 antigens antigen NNS cord-010092-uftc8inx 8791 33 , , , cord-010092-uftc8inx 8791 34 such such JJ cord-010092-uftc8inx 8791 35 as as IN cord-010092-uftc8inx 8791 36 Rh Rh NNP cord-010092-uftc8inx 8791 37 and and CC cord-010092-uftc8inx 8791 38 Kell Kell NNP cord-010092-uftc8inx 8791 39 antigens antigen NNS cord-010092-uftc8inx 8791 40 , , , cord-010092-uftc8inx 8791 41 is be VBZ cord-010092-uftc8inx 8791 42 yet yet RB cord-010092-uftc8inx 8791 43 to to TO cord-010092-uftc8inx 8791 44 be be VB cord-010092-uftc8inx 8791 45 explored explore VBN cord-010092-uftc8inx 8791 46 . . . cord-010092-uftc8inx 8792 1 Aims aim VBZ cord-010092-uftc8inx 8792 2 : : : cord-010092-uftc8inx 8792 3 To to TO cord-010092-uftc8inx 8792 4 determine determine VB cord-010092-uftc8inx 8792 5 the the DT cord-010092-uftc8inx 8792 6 frequency frequency NN cord-010092-uftc8inx 8792 7 of of IN cord-010092-uftc8inx 8792 8 the the DT cord-010092-uftc8inx 8792 9 following follow VBG cord-010092-uftc8inx 8792 10 clinically clinically RB cord-010092-uftc8inx 8792 11 relevant relevant JJ cord-010092-uftc8inx 8792 12 blood blood NN cord-010092-uftc8inx 8792 13 group group NN cord-010092-uftc8inx 8792 14 antigens antigen NNS cord-010092-uftc8inx 8792 15 ; ; : cord-010092-uftc8inx 8792 16 Rh(D Rh(D NNP cord-010092-uftc8inx 8792 17 , , , cord-010092-uftc8inx 8792 18 C C NNP cord-010092-uftc8inx 8792 19 , , , cord-010092-uftc8inx 8792 20 E E NNP cord-010092-uftc8inx 8792 21 , , , cord-010092-uftc8inx 8792 22 c c NNP cord-010092-uftc8inx 8792 23 , , , cord-010092-uftc8inx 8792 24 e e LS cord-010092-uftc8inx 8792 25 ) ) -RRB- cord-010092-uftc8inx 8792 26 and and CC cord-010092-uftc8inx 8792 27 K K NNP cord-010092-uftc8inx 8792 28 among among IN cord-010092-uftc8inx 8792 29 Saudi saudi JJ cord-010092-uftc8inx 8792 30 blood blood NN cord-010092-uftc8inx 8792 31 donors donor NNS cord-010092-uftc8inx 8792 32 in in IN cord-010092-uftc8inx 8792 33 King King NNP cord-010092-uftc8inx 8792 34 Fahd Fahd NNP cord-010092-uftc8inx 8792 35 Central Central NNP cord-010092-uftc8inx 8792 36 Hospital Hospital NNP cord-010092-uftc8inx 8792 37 in in IN cord-010092-uftc8inx 8792 38 Jazan Jazan NNP cord-010092-uftc8inx 8792 39 province province NN cord-010092-uftc8inx 8792 40 . . . cord-010092-uftc8inx 8793 1 Methods method NNS cord-010092-uftc8inx 8793 2 : : : cord-010092-uftc8inx 8794 1 A a DT cord-010092-uftc8inx 8794 2 retrospective retrospective JJ cord-010092-uftc8inx 8794 3 , , , cord-010092-uftc8inx 8794 4 cross cross JJ cord-010092-uftc8inx 8794 5 - - JJ cord-010092-uftc8inx 8794 6 sectional sectional JJ cord-010092-uftc8inx 8794 7 study study NN cord-010092-uftc8inx 8794 8 was be VBD cord-010092-uftc8inx 8794 9 carried carry VBN cord-010092-uftc8inx 8794 10 out out RP cord-010092-uftc8inx 8794 11 in in IN cord-010092-uftc8inx 8794 12 the the DT cord-010092-uftc8inx 8794 13 blood blood NN cord-010092-uftc8inx 8794 14 bank bank NN cord-010092-uftc8inx 8794 15 of of IN cord-010092-uftc8inx 8794 16 King King NNP cord-010092-uftc8inx 8794 17 Fahd Fahd NNP cord-010092-uftc8inx 8794 18 Central Central NNP cord-010092-uftc8inx 8794 19 Hospital Hospital NNP cord-010092-uftc8inx 8794 20 in in IN cord-010092-uftc8inx 8794 21 Jazan Jazan NNP cord-010092-uftc8inx 8794 22 province province NN cord-010092-uftc8inx 8794 23 . . . cord-010092-uftc8inx 8795 1 The the DT cord-010092-uftc8inx 8795 2 red red JJ cord-010092-uftc8inx 8795 3 cell cell NN cord-010092-uftc8inx 8795 4 phenotyping phenotyping NN cord-010092-uftc8inx 8795 5 records record NNS cord-010092-uftc8inx 8795 6 for for IN cord-010092-uftc8inx 8795 7 blood blood NN cord-010092-uftc8inx 8795 8 donation donation NN cord-010092-uftc8inx 8795 9 of of IN cord-010092-uftc8inx 8795 10 3243 3243 CD cord-010092-uftc8inx 8795 11 randomly randomly RB cord-010092-uftc8inx 8795 12 selected select VBN cord-010092-uftc8inx 8795 13 Saudi saudi JJ cord-010092-uftc8inx 8795 14 donors donor NNS cord-010092-uftc8inx 8795 15 , , , cord-010092-uftc8inx 8795 16 who who WP cord-010092-uftc8inx 8795 17 donated donate VBD cord-010092-uftc8inx 8795 18 blood blood NN cord-010092-uftc8inx 8795 19 between between IN cord-010092-uftc8inx 8795 20 January January NNP cord-010092-uftc8inx 8795 21 and and CC cord-010092-uftc8inx 8795 22 June June NNP cord-010092-uftc8inx 8795 23 2018 2018 CD cord-010092-uftc8inx 8795 24 , , , cord-010092-uftc8inx 8795 25 were be VBD cord-010092-uftc8inx 8795 26 reviewed review VBN cord-010092-uftc8inx 8795 27 to to TO cord-010092-uftc8inx 8795 28 identify identify VB cord-010092-uftc8inx 8795 29 the the DT cord-010092-uftc8inx 8795 30 prevalence prevalence NN cord-010092-uftc8inx 8795 31 for for IN cord-010092-uftc8inx 8795 32 the the DT cord-010092-uftc8inx 8795 33 following follow VBG cord-010092-uftc8inx 8795 34 antigens antigen NNS cord-010092-uftc8inx 8795 35 : : : cord-010092-uftc8inx 8795 36 D D NNP cord-010092-uftc8inx 8795 37 , , , cord-010092-uftc8inx 8795 38 C C NNP cord-010092-uftc8inx 8795 39 , , , cord-010092-uftc8inx 8795 40 E E NNP cord-010092-uftc8inx 8795 41 , , , cord-010092-uftc8inx 8795 42 c c NNP cord-010092-uftc8inx 8795 43 , , , cord-010092-uftc8inx 8795 44 e e NNP cord-010092-uftc8inx 8795 45 and and CC cord-010092-uftc8inx 8795 46 K. K. NNP cord-010092-uftc8inx 8795 47 The the DT cord-010092-uftc8inx 8795 48 hospital hospital NN cord-010092-uftc8inx 8795 49 blood blood NN cord-010092-uftc8inx 8795 50 bank bank NN cord-010092-uftc8inx 8795 51 routinely routinely RB cord-010092-uftc8inx 8795 52 performs perform VBZ cord-010092-uftc8inx 8795 53 Rh Rh NNP cord-010092-uftc8inx 8795 54 / / SYM cord-010092-uftc8inx 8795 55 K1 K1 NNP cord-010092-uftc8inx 8795 56 phenotyping phenotyping NN cord-010092-uftc8inx 8795 57 for for IN cord-010092-uftc8inx 8795 58 all all DT cord-010092-uftc8inx 8795 59 blood blood NN cord-010092-uftc8inx 8795 60 donation donation NN cord-010092-uftc8inx 8795 61 using use VBG cord-010092-uftc8inx 8795 62 either either CC cord-010092-uftc8inx 8795 63 Bio Bio NNP cord-010092-uftc8inx 8795 64 - - HYPH cord-010092-uftc8inx 8795 65 Rad Rad NNP cord-010092-uftc8inx 8795 66 or or CC cord-010092-uftc8inx 8795 67 Ortho Ortho NNP cord-010092-uftc8inx 8795 68 diagnostic diagnostic JJ cord-010092-uftc8inx 8795 69 Column Column NNP cord-010092-uftc8inx 8795 70 Agglutination Agglutination NNP cord-010092-uftc8inx 8795 71 Technology Technology NNP cord-010092-uftc8inx 8795 72 ( ( -LRB- cord-010092-uftc8inx 8795 73 CAT CAT NNP cord-010092-uftc8inx 8795 74 ) ) -RRB- cord-010092-uftc8inx 8795 75 platforms platform NNS cord-010092-uftc8inx 8795 76 . . . cord-010092-uftc8inx 8796 1 Phenotype phenotype NN cord-010092-uftc8inx 8796 2 frequencies frequency NNS cord-010092-uftc8inx 8796 3 were be VBD cord-010092-uftc8inx 8796 4 expressed express VBN cord-010092-uftc8inx 8796 5 as as IN cord-010092-uftc8inx 8796 6 percentages percentage NNS cord-010092-uftc8inx 8796 7 . . . cord-010092-uftc8inx 8797 1 Results result NNS cord-010092-uftc8inx 8797 2 : : : cord-010092-uftc8inx 8798 1 This this DT cord-010092-uftc8inx 8798 2 study study NN cord-010092-uftc8inx 8798 3 included include VBD cord-010092-uftc8inx 8798 4 a a DT cord-010092-uftc8inx 8798 5 total total NN cord-010092-uftc8inx 8798 6 of of IN cord-010092-uftc8inx 8798 7 3243 3243 CD cord-010092-uftc8inx 8798 8 Saudi saudi JJ cord-010092-uftc8inx 8798 9 voluntary voluntary JJ cord-010092-uftc8inx 8798 10 as as RB cord-010092-uftc8inx 8798 11 well well RB cord-010092-uftc8inx 8798 12 as as IN cord-010092-uftc8inx 8798 13 family family NN cord-010092-uftc8inx 8798 14 replacement replacement NN cord-010092-uftc8inx 8798 15 blood blood NN cord-010092-uftc8inx 8798 16 donors donor NNS cord-010092-uftc8inx 8798 17 . . . cord-010092-uftc8inx 8799 1 The the DT cord-010092-uftc8inx 8799 2 D d NN cord-010092-uftc8inx 8799 3 antigen antigen NN cord-010092-uftc8inx 8799 4 was be VBD cord-010092-uftc8inx 8799 5 found find VBN cord-010092-uftc8inx 8799 6 to to TO cord-010092-uftc8inx 8799 7 be be VB cord-010092-uftc8inx 8799 8 positive positive JJ cord-010092-uftc8inx 8799 9 in in IN cord-010092-uftc8inx 8799 10 93.7 93.7 CD cord-010092-uftc8inx 8799 11 % % NN cord-010092-uftc8inx 8799 12 , , , cord-010092-uftc8inx 8799 13 while while IN cord-010092-uftc8inx 8799 14 K K NNP cord-010092-uftc8inx 8799 15 antigen antigen NNP cord-010092-uftc8inx 8799 16 was be VBD cord-010092-uftc8inx 8799 17 positive positive JJ cord-010092-uftc8inx 8799 18 in in IN cord-010092-uftc8inx 8799 19 11.1 11.1 CD cord-010092-uftc8inx 8799 20 % % NN cord-010092-uftc8inx 8799 21 . . . cord-010092-uftc8inx 8800 1 Among among IN cord-010092-uftc8inx 8800 2 other other JJ cord-010092-uftc8inx 8800 3 studied study VBN cord-010092-uftc8inx 8800 4 Rh Rh NNP cord-010092-uftc8inx 8800 5 antigens antigen NNS cord-010092-uftc8inx 8800 6 , , , cord-010092-uftc8inx 8800 7 e e NNP cord-010092-uftc8inx 8800 8 was be VBD cord-010092-uftc8inx 8800 9 the the DT cord-010092-uftc8inx 8800 10 most most RBS cord-010092-uftc8inx 8800 11 common common JJ cord-010092-uftc8inx 8800 12 ( ( -LRB- cord-010092-uftc8inx 8800 13 98.1 98.1 CD cord-010092-uftc8inx 8800 14 % % NN cord-010092-uftc8inx 8800 15 ) ) -RRB- cord-010092-uftc8inx 8800 16 followed follow VBN cord-010092-uftc8inx 8800 17 by by IN cord-010092-uftc8inx 8800 18 c c NN cord-010092-uftc8inx 8800 19 ( ( -LRB- cord-010092-uftc8inx 8800 20 78.2 78.2 CD cord-010092-uftc8inx 8800 21 % % NN cord-010092-uftc8inx 8800 22 ) ) -RRB- cord-010092-uftc8inx 8800 23 , , , cord-010092-uftc8inx 8800 24 C C NNP cord-010092-uftc8inx 8800 25 ( ( -LRB- cord-010092-uftc8inx 8800 26 70.3 70.3 CD cord-010092-uftc8inx 8800 27 % % NN cord-010092-uftc8inx 8800 28 ) ) -RRB- cord-010092-uftc8inx 8800 29 and and CC cord-010092-uftc8inx 8800 30 E(26.9 e(26.9 CD cord-010092-uftc8inx 8800 31 % % NN cord-010092-uftc8inx 8800 32 ) ) -RRB- cord-010092-uftc8inx 8800 33 . . . cord-010092-uftc8inx 8801 1 DCe DCe NNP cord-010092-uftc8inx 8801 2 / / SYM cord-010092-uftc8inx 8801 3 dce dce NNP cord-010092-uftc8inx 8801 4 ( ( -LRB- cord-010092-uftc8inx 8801 5 34.2 34.2 CD cord-010092-uftc8inx 8801 6 % % NN cord-010092-uftc8inx 8801 7 ) ) -RRB- cord-010092-uftc8inx 8801 8 and and CC cord-010092-uftc8inx 8801 9 dce dce NNP cord-010092-uftc8inx 8801 10 / / SYM cord-010092-uftc8inx 8801 11 dce dce NNP cord-010092-uftc8inx 8801 12 ( ( -LRB- cord-010092-uftc8inx 8801 13 5.3 5.3 CD cord-010092-uftc8inx 8801 14 % % NN cord-010092-uftc8inx 8801 15 ) ) -RRB- cord-010092-uftc8inx 8801 16 were be VBD cord-010092-uftc8inx 8801 17 the the DT cord-010092-uftc8inx 8801 18 most most RBS cord-010092-uftc8inx 8801 19 common common JJ cord-010092-uftc8inx 8801 20 phenotypes phenotype NNS cord-010092-uftc8inx 8801 21 amongst amongst IN cord-010092-uftc8inx 8801 22 D d NN cord-010092-uftc8inx 8801 23 - - HYPH cord-010092-uftc8inx 8801 24 positive positive JJ cord-010092-uftc8inx 8801 25 and and CC cord-010092-uftc8inx 8801 26 Dnegative dnegative JJ cord-010092-uftc8inx 8801 27 donors donor NNS cord-010092-uftc8inx 8801 28 , , , cord-010092-uftc8inx 8801 29 respectively respectively RB cord-010092-uftc8inx 8801 30 . . . cord-010092-uftc8inx 8802 1 Surprisingly surprisingly RB cord-010092-uftc8inx 8802 2 , , , cord-010092-uftc8inx 8802 3 Dce Dce NNP cord-010092-uftc8inx 8802 4 / / SYM cord-010092-uftc8inx 8802 5 dce dce NNP cord-010092-uftc8inx 8802 6 phenotype phenotype NN cord-010092-uftc8inx 8802 7 was be VBD cord-010092-uftc8inx 8802 8 significantly significantly RB cord-010092-uftc8inx 8802 9 prevalent prevalent JJ cord-010092-uftc8inx 8802 10 ( ( -LRB- cord-010092-uftc8inx 8802 11 11.9 11.9 CD cord-010092-uftc8inx 8802 12 % % NN cord-010092-uftc8inx 8802 13 ) ) -RRB- cord-010092-uftc8inx 8802 14 with with IN cord-010092-uftc8inx 8802 15 almost almost RB cord-010092-uftc8inx 8802 16 5 5 CD cord-010092-uftc8inx 8802 17 times time NNS cord-010092-uftc8inx 8802 18 higher high JJR cord-010092-uftc8inx 8802 19 frequency frequency NN cord-010092-uftc8inx 8802 20 compared compare VBN cord-010092-uftc8inx 8802 21 that that WDT cord-010092-uftc8inx 8802 22 reported report VBD cord-010092-uftc8inx 8802 23 in in IN cord-010092-uftc8inx 8802 24 Caucasians Caucasians NNPS cord-010092-uftc8inx 8802 25 ( ( -LRB- cord-010092-uftc8inx 8802 26 2.0 2.0 CD cord-010092-uftc8inx 8802 27 % % NN cord-010092-uftc8inx 8802 28 ) ) -RRB- cord-010092-uftc8inx 8802 29 . . . cord-010092-uftc8inx 8803 1 The the DT cord-010092-uftc8inx 8803 2 rare rare JJ cord-010092-uftc8inx 8803 3 phenotype phenotype NN cord-010092-uftc8inx 8803 4 dCe dCe NNS cord-010092-uftc8inx 8803 5 / / , cord-010092-uftc8inx 8803 6 dCE dCE NNP cord-010092-uftc8inx 8803 7 was be VBD cord-010092-uftc8inx 8803 8 found find VBN cord-010092-uftc8inx 8803 9 in in IN cord-010092-uftc8inx 8803 10 3 3 CD cord-010092-uftc8inx 8803 11 donors donor NNS cord-010092-uftc8inx 8803 12 ( ( -LRB- cord-010092-uftc8inx 8803 13 0.09 0.09 CD cord-010092-uftc8inx 8803 14 % % NN cord-010092-uftc8inx 8803 15 ) ) -RRB- cord-010092-uftc8inx 8803 16 , , , cord-010092-uftc8inx 8803 17 while while IN cord-010092-uftc8inx 8803 18 DCE DCE NNP cord-010092-uftc8inx 8803 19 / / SYM cord-010092-uftc8inx 8803 20 DCE DCE NNP cord-010092-uftc8inx 8803 21 and and CC cord-010092-uftc8inx 8803 22 dcE dcE NNP cord-010092-uftc8inx 8803 23 / / SYM cord-010092-uftc8inx 8803 24 dCe dCe NNS cord-010092-uftc8inx 8803 25 phenotypes phenotype NNS cord-010092-uftc8inx 8803 26 were be VBD cord-010092-uftc8inx 8803 27 found find VBN cord-010092-uftc8inx 8803 28 in in IN cord-010092-uftc8inx 8803 29 only only RB cord-010092-uftc8inx 8803 30 one one CD cord-010092-uftc8inx 8803 31 donor donor NN cord-010092-uftc8inx 8803 32 each each DT cord-010092-uftc8inx 8803 33 . . . cord-010092-uftc8inx 8804 1 Summary Summary NNP cord-010092-uftc8inx 8804 2 / / SYM cord-010092-uftc8inx 8804 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 8804 4 : : : cord-010092-uftc8inx 8805 1 This this DT cord-010092-uftc8inx 8805 2 study study NN cord-010092-uftc8inx 8805 3 is be VBZ cord-010092-uftc8inx 8805 4 the the DT cord-010092-uftc8inx 8805 5 first first JJ cord-010092-uftc8inx 8805 6 to to TO cord-010092-uftc8inx 8805 7 determine determine VB cord-010092-uftc8inx 8805 8 the the DT cord-010092-uftc8inx 8805 9 frequency frequency NN cord-010092-uftc8inx 8805 10 of of IN cord-010092-uftc8inx 8805 11 Rh Rh NNP cord-010092-uftc8inx 8805 12 and and CC cord-010092-uftc8inx 8805 13 K K NNP cord-010092-uftc8inx 8805 14 antigens antigen NNS cord-010092-uftc8inx 8805 15 in in IN cord-010092-uftc8inx 8805 16 Saudi saudi JJ cord-010092-uftc8inx 8805 17 blood blood NN cord-010092-uftc8inx 8805 18 donors donor NNS cord-010092-uftc8inx 8805 19 in in IN cord-010092-uftc8inx 8805 20 Jazan Jazan NNP cord-010092-uftc8inx 8805 21 province province NN cord-010092-uftc8inx 8805 22 . . . cord-010092-uftc8inx 8806 1 Determination determination NN cord-010092-uftc8inx 8806 2 of of IN cord-010092-uftc8inx 8806 3 the the DT cord-010092-uftc8inx 8806 4 frequency frequency NN cord-010092-uftc8inx 8806 5 of of IN cord-010092-uftc8inx 8806 6 these these DT cord-010092-uftc8inx 8806 7 clinically clinically RB cord-010092-uftc8inx 8806 8 significant significant JJ cord-010092-uftc8inx 8806 9 antigens antigen NNS cord-010092-uftc8inx 8806 10 in in IN cord-010092-uftc8inx 8806 11 our -PRON- PRP$ cord-010092-uftc8inx 8806 12 geographical geographical JJ cord-010092-uftc8inx 8806 13 area area NN cord-010092-uftc8inx 8806 14 will will MD cord-010092-uftc8inx 8806 15 facilitate facilitate VB cord-010092-uftc8inx 8806 16 the the DT cord-010092-uftc8inx 8806 17 selection selection NN cord-010092-uftc8inx 8806 18 of of IN cord-010092-uftc8inx 8806 19 antigen antigen NN cord-010092-uftc8inx 8806 20 - - HYPH cord-010092-uftc8inx 8806 21 matched match VBN cord-010092-uftc8inx 8806 22 red red JJ cord-010092-uftc8inx 8806 23 cell cell NN cord-010092-uftc8inx 8806 24 units unit NNS cord-010092-uftc8inx 8806 25 for for IN cord-010092-uftc8inx 8806 26 transfusion transfusion NN cord-010092-uftc8inx 8806 27 in in IN cord-010092-uftc8inx 8806 28 recipients recipient NNS cord-010092-uftc8inx 8806 29 with with IN cord-010092-uftc8inx 8806 30 multiple multiple JJ cord-010092-uftc8inx 8806 31 alloantibodies alloantibody NNS cord-010092-uftc8inx 8806 32 . . . cord-010092-uftc8inx 8807 1 It -PRON- PRP cord-010092-uftc8inx 8807 2 will will MD cord-010092-uftc8inx 8807 3 also also RB cord-010092-uftc8inx 8807 4 help help VB cord-010092-uftc8inx 8807 5 in in IN cord-010092-uftc8inx 8807 6 the the DT cord-010092-uftc8inx 8807 7 management management NN cord-010092-uftc8inx 8807 8 of of IN cord-010092-uftc8inx 8807 9 blood blood NN cord-010092-uftc8inx 8807 10 donation donation NN cord-010092-uftc8inx 8807 11 processes process NNS cord-010092-uftc8inx 8807 12 and and CC cord-010092-uftc8inx 8807 13 planning plan VBG cord-010092-uftc8inx 8807 14 the the DT cord-010092-uftc8inx 8807 15 estimated estimate VBN cord-010092-uftc8inx 8807 16 need need NN cord-010092-uftc8inx 8807 17 of of IN cord-010092-uftc8inx 8807 18 blood blood NN cord-010092-uftc8inx 8807 19 stock stock NN cord-010092-uftc8inx 8807 20 of of IN cord-010092-uftc8inx 8807 21 different different JJ cord-010092-uftc8inx 8807 22 blood blood NN cord-010092-uftc8inx 8807 23 group group NN cord-010092-uftc8inx 8807 24 phenotypes phenotype NNS cord-010092-uftc8inx 8807 25 to to TO cord-010092-uftc8inx 8807 26 meet meet VB cord-010092-uftc8inx 8807 27 the the DT cord-010092-uftc8inx 8807 28 patient patient NN cord-010092-uftc8inx 8807 29 's 's POS cord-010092-uftc8inx 8807 30 needs need NNS cord-010092-uftc8inx 8807 31 . . . cord-010092-uftc8inx 8808 1 Abstract Abstract NNP cord-010092-uftc8inx 8808 2 withdrawn withdraw VBN cord-010092-uftc8inx 8808 3 . . . cord-010092-uftc8inx 8809 1 Background background NN cord-010092-uftc8inx 8809 2 : : : cord-010092-uftc8inx 8810 1 The the DT cord-010092-uftc8inx 8810 2 Gerbich Gerbich NNP cord-010092-uftc8inx 8810 3 ( ( -LRB- cord-010092-uftc8inx 8810 4 GE GE NNP cord-010092-uftc8inx 8810 5 ) ) -RRB- cord-010092-uftc8inx 8810 6 blood blood NN cord-010092-uftc8inx 8810 7 group group NN cord-010092-uftc8inx 8810 8 system system NN cord-010092-uftc8inx 8810 9 includes include VBZ cord-010092-uftc8inx 8810 10 several several JJ cord-010092-uftc8inx 8810 11 high high JJ cord-010092-uftc8inx 8810 12 - - HYPH cord-010092-uftc8inx 8810 13 frequency frequency NN cord-010092-uftc8inx 8810 14 antigens antigen NNS cord-010092-uftc8inx 8810 15 located locate VBN cord-010092-uftc8inx 8810 16 on on IN cord-010092-uftc8inx 8810 17 glycophorin glycophorin NNP cord-010092-uftc8inx 8810 18 C C NNP cord-010092-uftc8inx 8810 19 and and CC cord-010092-uftc8inx 8810 20 D. D. NNP cord-010092-uftc8inx 8811 1 With with IN cord-010092-uftc8inx 8811 2 only only RB cord-010092-uftc8inx 8811 3 few few JJ cord-010092-uftc8inx 8811 4 reports report NNS cord-010092-uftc8inx 8811 5 published publish VBN cord-010092-uftc8inx 8811 6 on on IN cord-010092-uftc8inx 8811 7 the the DT cord-010092-uftc8inx 8811 8 clinical clinical JJ cord-010092-uftc8inx 8811 9 significance significance NN cord-010092-uftc8inx 8811 10 of of IN cord-010092-uftc8inx 8811 11 antibodies antibody NNS cord-010092-uftc8inx 8811 12 directed direct VBN cord-010092-uftc8inx 8811 13 against against IN cord-010092-uftc8inx 8811 14 these these DT cord-010092-uftc8inx 8811 15 antigens antigen NNS cord-010092-uftc8inx 8811 16 , , , cord-010092-uftc8inx 8811 17 it -PRON- PRP cord-010092-uftc8inx 8811 18 is be VBZ cord-010092-uftc8inx 8811 19 unclear unclear JJ cord-010092-uftc8inx 8811 20 whether whether IN cord-010092-uftc8inx 8811 21 blood blood NN cord-010092-uftc8inx 8811 22 transfusions transfusion NNS cord-010092-uftc8inx 8811 23 have have VBP cord-010092-uftc8inx 8811 24 to to TO cord-010092-uftc8inx 8811 25 be be VB cord-010092-uftc8inx 8811 26 antigen antigen NN cord-010092-uftc8inx 8811 27 negative negative JJ cord-010092-uftc8inx 8811 28 in in IN cord-010092-uftc8inx 8811 29 the the DT cord-010092-uftc8inx 8811 30 presence presence NN cord-010092-uftc8inx 8811 31 of of IN cord-010092-uftc8inx 8811 32 an an DT cord-010092-uftc8inx 8811 33 anti anti JJ cord-010092-uftc8inx 8811 34 - - JJ cord-010092-uftc8inx 8811 35 Ge Ge NNP cord-010092-uftc8inx 8811 36 antibody antibody NN cord-010092-uftc8inx 8811 37 . . . cord-010092-uftc8inx 8812 1 The the DT cord-010092-uftc8inx 8812 2 monocyte monocyte JJ cord-010092-uftc8inx 8812 3 monolayer monolayer NN cord-010092-uftc8inx 8812 4 assay assay NN cord-010092-uftc8inx 8812 5 ( ( -LRB- cord-010092-uftc8inx 8812 6 MMA MMA NNP cord-010092-uftc8inx 8812 7 ) ) -RRB- cord-010092-uftc8inx 8812 8 is be VBZ cord-010092-uftc8inx 8812 9 an an DT cord-010092-uftc8inx 8812 10 in in IN cord-010092-uftc8inx 8812 11 - - HYPH cord-010092-uftc8inx 8812 12 vitro vitro FW cord-010092-uftc8inx 8812 13 method method NN cord-010092-uftc8inx 8812 14 used use VBN cord-010092-uftc8inx 8812 15 to to TO cord-010092-uftc8inx 8812 16 estimate estimate VB cord-010092-uftc8inx 8812 17 the the DT cord-010092-uftc8inx 8812 18 clinical clinical JJ cord-010092-uftc8inx 8812 19 significance significance NN cord-010092-uftc8inx 8812 20 of of IN cord-010092-uftc8inx 8812 21 alloantibodies alloantibody NNS cord-010092-uftc8inx 8812 22 . . . cord-010092-uftc8inx 8813 1 Aims aim VBZ cord-010092-uftc8inx 8813 2 : : : cord-010092-uftc8inx 8813 3 To to TO cord-010092-uftc8inx 8813 4 illustrate illustrate VB cord-010092-uftc8inx 8813 5 the the DT cord-010092-uftc8inx 8813 6 role role NN cord-010092-uftc8inx 8813 7 of of IN cord-010092-uftc8inx 8813 8 the the DT cord-010092-uftc8inx 8813 9 monocyte monocyte NNP cord-010092-uftc8inx 8813 10 monolayer monolayer NN cord-010092-uftc8inx 8813 11 assay assay NN cord-010092-uftc8inx 8813 12 ( ( -LRB- cord-010092-uftc8inx 8813 13 MMA MMA NNP cord-010092-uftc8inx 8813 14 ) ) -RRB- cord-010092-uftc8inx 8813 15 in in IN cord-010092-uftc8inx 8813 16 the the DT cord-010092-uftc8inx 8813 17 transfusion transfusion NN cord-010092-uftc8inx 8813 18 management management NN cord-010092-uftc8inx 8813 19 of of IN cord-010092-uftc8inx 8813 20 a a DT cord-010092-uftc8inx 8813 21 patient patient NN cord-010092-uftc8inx 8813 22 with with IN cord-010092-uftc8inx 8813 23 an an DT cord-010092-uftc8inx 8813 24 anti anti JJ cord-010092-uftc8inx 8813 25 - - JJ cord-010092-uftc8inx 8813 26 Ge Ge NNP cord-010092-uftc8inx 8813 27 alloantibody alloantibody NN cord-010092-uftc8inx 8813 28 . . . cord-010092-uftc8inx 8814 1 Methods method NNS cord-010092-uftc8inx 8814 2 : : : cord-010092-uftc8inx 8815 1 The the DT cord-010092-uftc8inx 8815 2 clinical clinical JJ cord-010092-uftc8inx 8815 3 and and CC cord-010092-uftc8inx 8815 4 transfusion transfusion NN cord-010092-uftc8inx 8815 5 history history NN cord-010092-uftc8inx 8815 6 was be VBD cord-010092-uftc8inx 8815 7 retrospectively retrospectively RB cord-010092-uftc8inx 8815 8 retrieved retrieve VBN cord-010092-uftc8inx 8815 9 from from IN cord-010092-uftc8inx 8815 10 the the DT cord-010092-uftc8inx 8815 11 patient patient NN cord-010092-uftc8inx 8815 12 's 's POS cord-010092-uftc8inx 8815 13 medical medical JJ cord-010092-uftc8inx 8815 14 records record NNS cord-010092-uftc8inx 8815 15 . . . cord-010092-uftc8inx 8816 1 Serological serological JJ cord-010092-uftc8inx 8816 2 investigations investigation NNS cord-010092-uftc8inx 8816 3 were be VBD cord-010092-uftc8inx 8816 4 performed perform VBN cord-010092-uftc8inx 8816 5 by by IN cord-010092-uftc8inx 8816 6 indirect indirect JJ cord-010092-uftc8inx 8816 7 antihuman antihuman JJ cord-010092-uftc8inx 8816 8 globulin globulin NN cord-010092-uftc8inx 8816 9 test test NN cord-010092-uftc8inx 8816 10 . . . cord-010092-uftc8inx 8817 1 Papain papain JJ cord-010092-uftc8inx 8817 2 and and CC cord-010092-uftc8inx 8817 3 trypsin trypsin NN cord-010092-uftc8inx 8817 4 treated treat VBN cord-010092-uftc8inx 8817 5 cells cell NNS cord-010092-uftc8inx 8817 6 were be VBD cord-010092-uftc8inx 8817 7 also also RB cord-010092-uftc8inx 8817 8 used use VBN cord-010092-uftc8inx 8817 9 . . . cord-010092-uftc8inx 8818 1 The the DT cord-010092-uftc8inx 8818 2 clinical clinical JJ cord-010092-uftc8inx 8818 3 significance significance NN cord-010092-uftc8inx 8818 4 of of IN cord-010092-uftc8inx 8818 5 the the DT cord-010092-uftc8inx 8818 6 antibody antibody NN cord-010092-uftc8inx 8818 7 was be VBD cord-010092-uftc8inx 8818 8 assessed assess VBN cord-010092-uftc8inx 8818 9 by by IN cord-010092-uftc8inx 8818 10 MMA MMA NNP cord-010092-uftc8inx 8818 11 . . . cord-010092-uftc8inx 8819 1 Genomic genomic JJ cord-010092-uftc8inx 8819 2 DNA dna NN cord-010092-uftc8inx 8819 3 was be VBD cord-010092-uftc8inx 8819 4 isolated isolate VBN cord-010092-uftc8inx 8819 5 from from IN cord-010092-uftc8inx 8819 6 whole whole JJ cord-010092-uftc8inx 8819 7 blood blood NN cord-010092-uftc8inx 8819 8 and and CC cord-010092-uftc8inx 8819 9 the the DT cord-010092-uftc8inx 8819 10 samples sample NNS cord-010092-uftc8inx 8819 11 were be VBD cord-010092-uftc8inx 8819 12 further further RB cord-010092-uftc8inx 8819 13 characterized characterize VBN cord-010092-uftc8inx 8819 14 by by IN cord-010092-uftc8inx 8819 15 PCR PCR NNP cord-010092-uftc8inx 8819 16 . . . cord-010092-uftc8inx 8820 1 Results result NNS cord-010092-uftc8inx 8820 2 : : : cord-010092-uftc8inx 8821 1 A a DT cord-010092-uftc8inx 8821 2 58-year 58-year JJ cord-010092-uftc8inx 8821 3 - - HYPH cord-010092-uftc8inx 8821 4 old old JJ cord-010092-uftc8inx 8821 5 male male JJ cord-010092-uftc8inx 8821 6 patient patient NN cord-010092-uftc8inx 8821 7 with with IN cord-010092-uftc8inx 8821 8 lung lung NN cord-010092-uftc8inx 8821 9 cancer cancer NN cord-010092-uftc8inx 8821 10 without without IN cord-010092-uftc8inx 8821 11 previous previous JJ cord-010092-uftc8inx 8821 12 transfusions transfusion NNS cord-010092-uftc8inx 8821 13 was be VBD cord-010092-uftc8inx 8821 14 admitted admit VBN cord-010092-uftc8inx 8821 15 ( ( -LRB- cord-010092-uftc8inx 8821 16 06/2009 06/2009 CD cord-010092-uftc8inx 8821 17 ) ) -RRB- cord-010092-uftc8inx 8821 18 for for IN cord-010092-uftc8inx 8821 19 surgery surgery NN cord-010092-uftc8inx 8821 20 . . . cord-010092-uftc8inx 8822 1 His -PRON- PRP$ cord-010092-uftc8inx 8822 2 hemoglobin hemoglobin NN cord-010092-uftc8inx 8822 3 was be VBD cord-010092-uftc8inx 8822 4 13.2 13.2 CD cord-010092-uftc8inx 8823 1 g g NNP cord-010092-uftc8inx 8823 2 / / SYM cord-010092-uftc8inx 8823 3 L. L. NNP cord-010092-uftc8inx 8823 4 An An NNP cord-010092-uftc8inx 8823 5 anti anti JJ cord-010092-uftc8inx 8823 6 - - JJ cord-010092-uftc8inx 8823 7 Ge Ge NNP cord-010092-uftc8inx 8823 8 antibody antibody NN cord-010092-uftc8inx 8823 9 was be VBD cord-010092-uftc8inx 8823 10 detected detect VBN cord-010092-uftc8inx 8823 11 and and CC cord-010092-uftc8inx 8823 12 it -PRON- PRP cord-010092-uftc8inx 8823 13 was be VBD cord-010092-uftc8inx 8823 14 decided decide VBN cord-010092-uftc8inx 8823 15 to to TO cord-010092-uftc8inx 8823 16 transfuse transfuse VB cord-010092-uftc8inx 8823 17 Ge Ge NNP cord-010092-uftc8inx 8823 18 - - HYPH cord-010092-uftc8inx 8823 19 positive positive JJ cord-010092-uftc8inx 8823 20 packed pack VBN cord-010092-uftc8inx 8823 21 red red JJ cord-010092-uftc8inx 8823 22 blood blood NN cord-010092-uftc8inx 8823 23 cells cell NNS cord-010092-uftc8inx 8823 24 ( ( -LRB- cord-010092-uftc8inx 8823 25 pRBCs prbcs RB cord-010092-uftc8inx 8823 26 ) ) -RRB- cord-010092-uftc8inx 8823 27 . . . cord-010092-uftc8inx 8824 1 However however RB cord-010092-uftc8inx 8824 2 , , , cord-010092-uftc8inx 8824 3 no no DT cord-010092-uftc8inx 8824 4 blood blood NN cord-010092-uftc8inx 8824 5 transfusion transfusion NN cord-010092-uftc8inx 8824 6 was be VBD cord-010092-uftc8inx 8824 7 needed need VBN cord-010092-uftc8inx 8824 8 . . . cord-010092-uftc8inx 8825 1 In in IN cord-010092-uftc8inx 8825 2 July July NNP cord-010092-uftc8inx 8825 3 2017 2017 CD cord-010092-uftc8inx 8825 4 , , , cord-010092-uftc8inx 8825 5 the the DT cord-010092-uftc8inx 8825 6 patient patient NN cord-010092-uftc8inx 8825 7 was be VBD cord-010092-uftc8inx 8825 8 admitted admit VBN cord-010092-uftc8inx 8825 9 for for IN cord-010092-uftc8inx 8825 10 colon colon NN cord-010092-uftc8inx 8825 11 cancer cancer NN cord-010092-uftc8inx 8825 12 surgery surgery NN cord-010092-uftc8inx 8825 13 with with IN cord-010092-uftc8inx 8825 14 a a DT cord-010092-uftc8inx 8825 15 hemoglobin hemoglobin NN cord-010092-uftc8inx 8825 16 of of IN cord-010092-uftc8inx 8825 17 11,0 11,0 CD cord-010092-uftc8inx 8825 18 g g NN cord-010092-uftc8inx 8825 19 / / SYM cord-010092-uftc8inx 8825 20 dl dl NN cord-010092-uftc8inx 8825 21 . . . cord-010092-uftc8inx 8826 1 The the DT cord-010092-uftc8inx 8826 2 Anti Anti NNP cord-010092-uftc8inx 8826 3 - - NNP cord-010092-uftc8inx 8826 4 Ge Ge NNP cord-010092-uftc8inx 8826 5 alloantibody alloantibody NN cord-010092-uftc8inx 8826 6 was be VBD cord-010092-uftc8inx 8826 7 still still RB cord-010092-uftc8inx 8826 8 detectable detectable JJ cord-010092-uftc8inx 8826 9 and and CC cord-010092-uftc8inx 8826 10 a a DT cord-010092-uftc8inx 8826 11 SSP SSP NNP cord-010092-uftc8inx 8826 12 - - HYPH cord-010092-uftc8inx 8826 13 PCR PCR NNP cord-010092-uftc8inx 8826 14 revealed reveal VBD cord-010092-uftc8inx 8826 15 the the DT cord-010092-uftc8inx 8826 16 genotype genotype NN cord-010092-uftc8inx 8826 17 GE*01.-03 ge*01.-03 NN cord-010092-uftc8inx 8826 18 . . . cord-010092-uftc8inx 8827 1 An an DT cord-010092-uftc8inx 8827 2 MMA MMA NNP cord-010092-uftc8inx 8827 3 performed perform VBD cord-010092-uftc8inx 8827 4 on on IN cord-010092-uftc8inx 8827 5 the the DT cord-010092-uftc8inx 8827 6 pre pre JJ cord-010092-uftc8inx 8827 7 - - JJ cord-010092-uftc8inx 8827 8 transfusion transfusion JJ cord-010092-uftc8inx 8827 9 sample sample NN cord-010092-uftc8inx 8827 10 revealed reveal VBD cord-010092-uftc8inx 8827 11 a a DT cord-010092-uftc8inx 8827 12 monocyte monocyte NNP cord-010092-uftc8inx 8827 13 index index NN cord-010092-uftc8inx 8827 14 ( ( -LRB- cord-010092-uftc8inx 8827 15 MI MI NNP cord-010092-uftc8inx 8827 16 ) ) -RRB- cord-010092-uftc8inx 8827 17 of of IN cord-010092-uftc8inx 8827 18 0.35 0.35 CD cord-010092-uftc8inx 8827 19 % % NN cord-010092-uftc8inx 8827 20 and and CC cord-010092-uftc8inx 8827 21 the the DT cord-010092-uftc8inx 8827 22 antibody antibody NN cord-010092-uftc8inx 8827 23 was be VBD cord-010092-uftc8inx 8827 24 considered consider VBN cord-010092-uftc8inx 8827 25 not not RB cord-010092-uftc8inx 8827 26 to to TO cord-010092-uftc8inx 8827 27 be be VB cord-010092-uftc8inx 8827 28 clinically clinically RB cord-010092-uftc8inx 8827 29 relevant relevant JJ cord-010092-uftc8inx 8827 30 . . . cord-010092-uftc8inx 8828 1 The the DT cord-010092-uftc8inx 8828 2 MI MI NNP cord-010092-uftc8inx 8828 3 was be VBD cord-010092-uftc8inx 8828 4 interpreted interpret VBN cord-010092-uftc8inx 8828 5 as as IN cord-010092-uftc8inx 8828 6 following follow VBG cord-010092-uftc8inx 8828 7 : : : cord-010092-uftc8inx 8828 8 0 0 CD cord-010092-uftc8inx 8828 9 - - SYM cord-010092-uftc8inx 8828 10 3 3 CD cord-010092-uftc8inx 8828 11 % % NN cord-010092-uftc8inx 8828 12 not not RB cord-010092-uftc8inx 8828 13 significant significant JJ cord-010092-uftc8inx 8828 14 ; ; : cord-010092-uftc8inx 8828 15 3 3 CD cord-010092-uftc8inx 8828 16 - - SYM cord-010092-uftc8inx 8828 17 5 5 CD cord-010092-uftc8inx 8828 18 % % NN cord-010092-uftc8inx 8828 19 inconclusive inconclusive JJ cord-010092-uftc8inx 8828 20 ; ; : cord-010092-uftc8inx 8828 21 > > SYM cord-010092-uftc8inx 8828 22 5 5 CD cord-010092-uftc8inx 8828 23 % % NN cord-010092-uftc8inx 8828 24 clinical clinical JJ cord-010092-uftc8inx 8828 25 significant significant JJ cord-010092-uftc8inx 8828 26 . . . cord-010092-uftc8inx 8829 1 However however RB cord-010092-uftc8inx 8829 2 , , , cord-010092-uftc8inx 8829 3 due due IN cord-010092-uftc8inx 8829 4 to to IN cord-010092-uftc8inx 8829 5 the the DT cord-010092-uftc8inx 8829 6 clinical clinical JJ cord-010092-uftc8inx 8829 7 background background NN cord-010092-uftc8inx 8829 8 of of IN cord-010092-uftc8inx 8829 9 the the DT cord-010092-uftc8inx 8829 10 patient patient NN cord-010092-uftc8inx 8829 11 it -PRON- PRP cord-010092-uftc8inx 8829 12 was be VBD cord-010092-uftc8inx 8829 13 decided decide VBN cord-010092-uftc8inx 8829 14 to to TO cord-010092-uftc8inx 8829 15 transfuse transfuse VB cord-010092-uftc8inx 8829 16 Ge Ge NNP cord-010092-uftc8inx 8829 17 - - HYPH cord-010092-uftc8inx 8829 18 negative negative JJ cord-010092-uftc8inx 8829 19 pRBCs prbcs RB cord-010092-uftc8inx 8829 20 , , , cord-010092-uftc8inx 8829 21 which which WDT cord-010092-uftc8inx 8829 22 were be VBD cord-010092-uftc8inx 8829 23 obtained obtain VBN cord-010092-uftc8inx 8829 24 from from IN cord-010092-uftc8inx 8829 25 Etablissement Etablissement NNP cord-010092-uftc8inx 8829 26 Francais Francais NNP cord-010092-uftc8inx 8829 27 du du NNP cord-010092-uftc8inx 8829 28 Sang Sang NNP cord-010092-uftc8inx 8829 29 ( ( -LRB- cord-010092-uftc8inx 8829 30 EFS EFS NNP cord-010092-uftc8inx 8829 31 ) ) -RRB- cord-010092-uftc8inx 8829 32 , , , cord-010092-uftc8inx 8829 33 Paris Paris NNP cord-010092-uftc8inx 8829 34 , , , cord-010092-uftc8inx 8829 35 France France NNP cord-010092-uftc8inx 8829 36 . . . cord-010092-uftc8inx 8830 1 Two two CD cord-010092-uftc8inx 8830 2 days day NNS cord-010092-uftc8inx 8830 3 after after IN cord-010092-uftc8inx 8830 4 surgery surgery NN cord-010092-uftc8inx 8830 5 , , , cord-010092-uftc8inx 8830 6 the the DT cord-010092-uftc8inx 8830 7 patient patient NN cord-010092-uftc8inx 8830 8 received receive VBD cord-010092-uftc8inx 8830 9 2 2 CD cord-010092-uftc8inx 8830 10 units unit NNS cord-010092-uftc8inx 8830 11 of of IN cord-010092-uftc8inx 8830 12 GE:-2,-3 ge:-2,-3 JJ cord-010092-uftc8inx 8830 13 pRBCs prbcs RB cord-010092-uftc8inx 8830 14 without without IN cord-010092-uftc8inx 8830 15 any any DT cord-010092-uftc8inx 8830 16 transfusion transfusion NN cord-010092-uftc8inx 8830 17 reaction reaction NN cord-010092-uftc8inx 8830 18 . . . cord-010092-uftc8inx 8831 1 One one CD cord-010092-uftc8inx 8831 2 and and CC cord-010092-uftc8inx 8831 3 a a DT cord-010092-uftc8inx 8831 4 half half JJ cord-010092-uftc8inx 8831 5 year year NN cord-010092-uftc8inx 8831 6 later later RB cord-010092-uftc8inx 8831 7 ( ( -LRB- cord-010092-uftc8inx 8831 8 11/2018 11/2018 CD cord-010092-uftc8inx 8831 9 ) ) -RRB- cord-010092-uftc8inx 8831 10 , , , cord-010092-uftc8inx 8831 11 peritoneal peritoneal JJ cord-010092-uftc8inx 8831 12 carcinomatosis carcinomatosis NN cord-010092-uftc8inx 8831 13 , , , cord-010092-uftc8inx 8831 14 as as IN cord-010092-uftc8inx 8831 15 a a DT cord-010092-uftc8inx 8831 16 complication complication NN cord-010092-uftc8inx 8831 17 of of IN cord-010092-uftc8inx 8831 18 colon colon NN cord-010092-uftc8inx 8831 19 cancer cancer NN cord-010092-uftc8inx 8831 20 , , , cord-010092-uftc8inx 8831 21 was be VBD cord-010092-uftc8inx 8831 22 diagnosed diagnose VBN cord-010092-uftc8inx 8831 23 . . . cord-010092-uftc8inx 8832 1 The the DT cord-010092-uftc8inx 8832 2 patient patient NN cord-010092-uftc8inx 8832 3 's 's POS cord-010092-uftc8inx 8832 4 hemoglobin hemoglobin NN cord-010092-uftc8inx 8832 5 was be VBD cord-010092-uftc8inx 8832 6 87 87 CD cord-010092-uftc8inx 8832 7 g g NN cord-010092-uftc8inx 8832 8 / / SYM cord-010092-uftc8inx 8832 9 L L NNP cord-010092-uftc8inx 8832 10 and and CC cord-010092-uftc8inx 8832 11 he -PRON- PRP cord-010092-uftc8inx 8832 12 had have VBD cord-010092-uftc8inx 8832 13 a a DT cord-010092-uftc8inx 8832 14 passage passage NN cord-010092-uftc8inx 8832 15 disorder disorder NN cord-010092-uftc8inx 8832 16 , , , cord-010092-uftc8inx 8832 17 symptoms symptom NNS cord-010092-uftc8inx 8832 18 of of IN cord-010092-uftc8inx 8832 19 deterioration deterioration NN cord-010092-uftc8inx 8832 20 and and CC cord-010092-uftc8inx 8832 21 an an DT cord-010092-uftc8inx 8832 22 adynamia adynamia NN cord-010092-uftc8inx 8832 23 . . . cord-010092-uftc8inx 8833 1 Based base VBN cord-010092-uftc8inx 8833 2 on on IN cord-010092-uftc8inx 8833 3 the the DT cord-010092-uftc8inx 8833 4 MMA MMA NNP cord-010092-uftc8inx 8833 5 results result NNS cord-010092-uftc8inx 8833 6 from from IN cord-010092-uftc8inx 8833 7 July July NNP cord-010092-uftc8inx 8833 8 2017 2017 CD cord-010092-uftc8inx 8833 9 indicating indicate VBG cord-010092-uftc8inx 8833 10 no no DT cord-010092-uftc8inx 8833 11 clinical clinical JJ cord-010092-uftc8inx 8833 12 significance significance NN cord-010092-uftc8inx 8833 13 of of IN cord-010092-uftc8inx 8833 14 the the DT cord-010092-uftc8inx 8833 15 antibody antibody NN cord-010092-uftc8inx 8833 16 , , , cord-010092-uftc8inx 8833 17 it -PRON- PRP cord-010092-uftc8inx 8833 18 was be VBD cord-010092-uftc8inx 8833 19 decided decide VBN cord-010092-uftc8inx 8833 20 to to TO cord-010092-uftc8inx 8833 21 transfuse transfuse VB cord-010092-uftc8inx 8833 22 Ge Ge NNP cord-010092-uftc8inx 8833 23 - - HYPH cord-010092-uftc8inx 8833 24 positive positive JJ cord-010092-uftc8inx 8833 25 pRBCs prbc NNS cord-010092-uftc8inx 8833 26 . . . cord-010092-uftc8inx 8834 1 In in IN cord-010092-uftc8inx 8834 2 the the DT cord-010092-uftc8inx 8834 3 following follow VBG cord-010092-uftc8inx 8834 4 16 16 CD cord-010092-uftc8inx 8834 5 days day NNS cord-010092-uftc8inx 8834 6 the the DT cord-010092-uftc8inx 8834 7 patient patient NN cord-010092-uftc8inx 8834 8 received receive VBD cord-010092-uftc8inx 8834 9 a a DT cord-010092-uftc8inx 8834 10 total total NN cord-010092-uftc8inx 8834 11 of of IN cord-010092-uftc8inx 8834 12 5 5 CD cord-010092-uftc8inx 8834 13 units unit NNS cord-010092-uftc8inx 8834 14 of of IN cord-010092-uftc8inx 8834 15 Gepositive Gepositive NNP cord-010092-uftc8inx 8834 16 pRBCs prbcs RB cord-010092-uftc8inx 8835 1 No no DT cord-010092-uftc8inx 8835 2 immediate immediate JJ cord-010092-uftc8inx 8835 3 or or CC cord-010092-uftc8inx 8835 4 delayed delayed JJ cord-010092-uftc8inx 8835 5 transfusion transfusion NN cord-010092-uftc8inx 8835 6 reaction reaction NN cord-010092-uftc8inx 8835 7 were be VBD cord-010092-uftc8inx 8835 8 observed observe VBN cord-010092-uftc8inx 8835 9 following follow VBG cord-010092-uftc8inx 8835 10 these these DT cord-010092-uftc8inx 8835 11 transfusions transfusion NNS cord-010092-uftc8inx 8835 12 . . . cord-010092-uftc8inx 8836 1 Two two CD cord-010092-uftc8inx 8836 2 further further JJ cord-010092-uftc8inx 8836 3 MMA MMA NNP cord-010092-uftc8inx 8836 4 's 's POS cord-010092-uftc8inx 8836 5 , , , cord-010092-uftc8inx 8836 6 performed perform VBN cord-010092-uftc8inx 8836 7 on on IN cord-010092-uftc8inx 8836 8 samples sample NNS cord-010092-uftc8inx 8836 9 drawn draw VBN cord-010092-uftc8inx 8836 10 on on IN cord-010092-uftc8inx 8836 11 December December NNP cord-010092-uftc8inx 8836 12 12 12 CD cord-010092-uftc8inx 8836 13 th th XX cord-010092-uftc8inx 8836 14 and and CC cord-010092-uftc8inx 8836 15 16 16 CD cord-010092-uftc8inx 8836 16 th th XX cord-010092-uftc8inx 8836 17 ( ( -LRB- cord-010092-uftc8inx 8836 18 12 12 CD cord-010092-uftc8inx 8836 19 days day NNS cord-010092-uftc8inx 8836 20 after after IN cord-010092-uftc8inx 8836 21 transfusion transfusion NN cord-010092-uftc8inx 8836 22 of of IN cord-010092-uftc8inx 8836 23 a a DT cord-010092-uftc8inx 8836 24 total total NN cord-010092-uftc8inx 8836 25 of of IN cord-010092-uftc8inx 8836 26 three three CD cord-010092-uftc8inx 8836 27 and and CC cord-010092-uftc8inx 8836 28 two two CD cord-010092-uftc8inx 8836 29 days day NNS cord-010092-uftc8inx 8836 30 after after IN cord-010092-uftc8inx 8836 31 two two CD cord-010092-uftc8inx 8836 32 further further JJ cord-010092-uftc8inx 8836 33 pRBCs prbc NNS cord-010092-uftc8inx 8836 34 respectively respectively RB cord-010092-uftc8inx 8836 35 ) ) -RRB- cord-010092-uftc8inx 8836 36 , , , cord-010092-uftc8inx 8836 37 showed show VBD cord-010092-uftc8inx 8836 38 a a DT cord-010092-uftc8inx 8836 39 MI MI NNP cord-010092-uftc8inx 8836 40 of of IN cord-010092-uftc8inx 8836 41 0.8 0.8 CD cord-010092-uftc8inx 8836 42 % % NN cord-010092-uftc8inx 8836 43 und und IN cord-010092-uftc8inx 8836 44 1 1 CD cord-010092-uftc8inx 8836 45 % % NN cord-010092-uftc8inx 8836 46 respectively respectively RB cord-010092-uftc8inx 8836 47 and and CC cord-010092-uftc8inx 8836 48 the the DT cord-010092-uftc8inx 8836 49 anti anti JJ cord-010092-uftc8inx 8836 50 - - JJ cord-010092-uftc8inx 8836 51 Ge Ge NNP cord-010092-uftc8inx 8836 52 antibody antibody NN cord-010092-uftc8inx 8836 53 was be VBD cord-010092-uftc8inx 8836 54 considered consider VBN cord-010092-uftc8inx 8836 55 still still RB cord-010092-uftc8inx 8836 56 not not RB cord-010092-uftc8inx 8836 57 to to TO cord-010092-uftc8inx 8836 58 be be VB cord-010092-uftc8inx 8836 59 clinically clinically RB cord-010092-uftc8inx 8836 60 significant significant JJ cord-010092-uftc8inx 8836 61 . . . cord-010092-uftc8inx 8837 1 Summary Summary NNP cord-010092-uftc8inx 8837 2 / / SYM cord-010092-uftc8inx 8837 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 8838 1 : : : cord-010092-uftc8inx 8838 2 We -PRON- PRP cord-010092-uftc8inx 8838 3 report report VBP cord-010092-uftc8inx 8838 4 the the DT cord-010092-uftc8inx 8838 5 case case NN cord-010092-uftc8inx 8838 6 of of IN cord-010092-uftc8inx 8838 7 a a DT cord-010092-uftc8inx 8838 8 patient patient NN cord-010092-uftc8inx 8838 9 with with IN cord-010092-uftc8inx 8838 10 an an DT cord-010092-uftc8inx 8838 11 anti anti JJ cord-010092-uftc8inx 8838 12 - - JJ cord-010092-uftc8inx 8838 13 Ge Ge NNP cord-010092-uftc8inx 8838 14 antibody antibody NN cord-010092-uftc8inx 8838 15 transfused transfuse VBN cord-010092-uftc8inx 8838 16 with with IN cord-010092-uftc8inx 8838 17 Ge Ge NNP cord-010092-uftc8inx 8838 18 - - HYPH cord-010092-uftc8inx 8838 19 positive positive JJ cord-010092-uftc8inx 8838 20 pRBC pRBC NNS cord-010092-uftc8inx 8838 21 . . . cord-010092-uftc8inx 8839 1 As as IN cord-010092-uftc8inx 8839 2 Ge Ge NNP cord-010092-uftc8inx 8839 3 - - HYPH cord-010092-uftc8inx 8839 4 negative negative JJ cord-010092-uftc8inx 8839 5 pRBC pRBC NNS cord-010092-uftc8inx 8839 6 are be VBP cord-010092-uftc8inx 8839 7 not not RB cord-010092-uftc8inx 8839 8 available available JJ cord-010092-uftc8inx 8839 9 in in IN cord-010092-uftc8inx 8839 10 Switzerland Switzerland NNP cord-010092-uftc8inx 8839 11 and and CC cord-010092-uftc8inx 8839 12 not not RB cord-010092-uftc8inx 8839 13 easy easy JJ cord-010092-uftc8inx 8839 14 to to TO cord-010092-uftc8inx 8839 15 obtain obtain VB cord-010092-uftc8inx 8839 16 internationally internationally RB cord-010092-uftc8inx 8839 17 the the DT cord-010092-uftc8inx 8839 18 MMA MMA NNP cord-010092-uftc8inx 8839 19 can can MD cord-010092-uftc8inx 8839 20 help help VB cord-010092-uftc8inx 8839 21 in in IN cord-010092-uftc8inx 8839 22 the the DT cord-010092-uftc8inx 8839 23 decision decision NN cord-010092-uftc8inx 8839 24 on on IN cord-010092-uftc8inx 8839 25 how how WRB cord-010092-uftc8inx 8839 26 to to TO cord-010092-uftc8inx 8839 27 transfuse transfuse VB cord-010092-uftc8inx 8839 28 . . . cord-010092-uftc8inx 8840 1 In in IN cord-010092-uftc8inx 8840 2 this this DT cord-010092-uftc8inx 8840 3 case case NN cord-010092-uftc8inx 8840 4 , , , cord-010092-uftc8inx 8840 5 the the DT cord-010092-uftc8inx 8840 6 clinical clinical JJ cord-010092-uftc8inx 8840 7 course course NN cord-010092-uftc8inx 8840 8 confirmed confirm VBD cord-010092-uftc8inx 8840 9 the the DT cord-010092-uftc8inx 8840 10 MMA MMA NNP cord-010092-uftc8inx 8840 11 - - HYPH cord-010092-uftc8inx 8840 12 based base VBN cord-010092-uftc8inx 8840 13 prediction prediction NN cord-010092-uftc8inx 8840 14 . . . cord-010092-uftc8inx 8841 1 Transfusions transfusion NNS cord-010092-uftc8inx 8841 2 of of IN cord-010092-uftc8inx 8841 3 Ge Ge NNP cord-010092-uftc8inx 8841 4 - - HYPH cord-010092-uftc8inx 8841 5 positive positive JJ cord-010092-uftc8inx 8841 6 pRBCs prbc NNS cord-010092-uftc8inx 8841 7 were be VBD cord-010092-uftc8inx 8841 8 tolerated tolerate VBN cord-010092-uftc8inx 8841 9 without without IN cord-010092-uftc8inx 8841 10 signs sign NNS cord-010092-uftc8inx 8841 11 or or CC cord-010092-uftc8inx 8841 12 symptoms symptom NNS cord-010092-uftc8inx 8841 13 of of IN cord-010092-uftc8inx 8841 14 immediate immediate JJ cord-010092-uftc8inx 8841 15 or or CC cord-010092-uftc8inx 8841 16 delayed delayed JJ cord-010092-uftc8inx 8841 17 transfusion transfusion NN cord-010092-uftc8inx 8841 18 reactions reaction NNS cord-010092-uftc8inx 8841 19 . . . cord-010092-uftc8inx 8842 1 Background background NN cord-010092-uftc8inx 8842 2 : : : cord-010092-uftc8inx 8843 1 ABO ABO NNP cord-010092-uftc8inx 8843 2 grouping grouping NN cord-010092-uftc8inx 8843 3 discrepancies discrepancy NNS cord-010092-uftc8inx 8843 4 occur occur VBP cord-010092-uftc8inx 8843 5 when when WRB cord-010092-uftc8inx 8843 6 the the DT cord-010092-uftc8inx 8843 7 results result NNS cord-010092-uftc8inx 8843 8 of of IN cord-010092-uftc8inx 8843 9 forward forward JJ cord-010092-uftc8inx 8843 10 grouping grouping NN cord-010092-uftc8inx 8843 11 are be VBP cord-010092-uftc8inx 8843 12 not not RB cord-010092-uftc8inx 8843 13 corroborative corroborative JJ cord-010092-uftc8inx 8843 14 to to IN cord-010092-uftc8inx 8843 15 those those DT cord-010092-uftc8inx 8843 16 of of IN cord-010092-uftc8inx 8843 17 the the DT cord-010092-uftc8inx 8843 18 reverse reverse JJ cord-010092-uftc8inx 8843 19 grouping grouping NN cord-010092-uftc8inx 8843 20 . . . cord-010092-uftc8inx 8844 1 These these DT cord-010092-uftc8inx 8844 2 may may MD cord-010092-uftc8inx 8844 3 be be VB cord-010092-uftc8inx 8844 4 due due JJ cord-010092-uftc8inx 8844 5 to to IN cord-010092-uftc8inx 8844 6 weak weak JJ cord-010092-uftc8inx 8844 7 subgroups subgroup NNS cord-010092-uftc8inx 8844 8 of of IN cord-010092-uftc8inx 8844 9 A a NN cord-010092-uftc8inx 8844 10 and and CC cord-010092-uftc8inx 8844 11 B b NN cord-010092-uftc8inx 8844 12 , , , cord-010092-uftc8inx 8844 13 missing missing JJ cord-010092-uftc8inx 8844 14 or or CC cord-010092-uftc8inx 8844 15 weak weak JJ cord-010092-uftc8inx 8844 16 ABO ABO NNP cord-010092-uftc8inx 8844 17 antibodies antibody NNS cord-010092-uftc8inx 8844 18 or or CC cord-010092-uftc8inx 8844 19 red red JJ cord-010092-uftc8inx 8844 20 cell cell NN cord-010092-uftc8inx 8844 21 alloantibodies alloantibody NNS cord-010092-uftc8inx 8844 22 . . . cord-010092-uftc8inx 8845 1 Determination determination NN cord-010092-uftc8inx 8845 2 of of IN cord-010092-uftc8inx 8845 3 correct correct JJ cord-010092-uftc8inx 8845 4 ABO ABO NNP cord-010092-uftc8inx 8845 5 blood blood NN cord-010092-uftc8inx 8845 6 group group NN cord-010092-uftc8inx 8845 7 of of IN cord-010092-uftc8inx 8845 8 a a DT cord-010092-uftc8inx 8845 9 donor donor NN cord-010092-uftc8inx 8845 10 is be VBZ cord-010092-uftc8inx 8845 11 essential essential JJ cord-010092-uftc8inx 8845 12 for for IN cord-010092-uftc8inx 8845 13 preventing prevent VBG cord-010092-uftc8inx 8845 14 ABO ABO NNP cord-010092-uftc8inx 8845 15 incompatible incompatible JJ cord-010092-uftc8inx 8845 16 transfusions transfusion NNS cord-010092-uftc8inx 8845 17 and and CC cord-010092-uftc8inx 8845 18 to to TO cord-010092-uftc8inx 8845 19 avoid avoid VB cord-010092-uftc8inx 8845 20 hemolytic hemolytic JJ cord-010092-uftc8inx 8845 21 transfusion transfusion NN cord-010092-uftc8inx 8845 22 reactions reaction NNS cord-010092-uftc8inx 8845 23 in in IN cord-010092-uftc8inx 8845 24 the the DT cord-010092-uftc8inx 8845 25 recipient recipient NN cord-010092-uftc8inx 8845 26 . . . cord-010092-uftc8inx 8846 1 Aims aim VBZ cord-010092-uftc8inx 8846 2 : : : cord-010092-uftc8inx 8846 3 To to TO cord-010092-uftc8inx 8846 4 determine determine VB cord-010092-uftc8inx 8846 5 the the DT cord-010092-uftc8inx 8846 6 frequency frequency NN cord-010092-uftc8inx 8846 7 of of IN cord-010092-uftc8inx 8846 8 ABO ABO NNP cord-010092-uftc8inx 8846 9 discrepancies discrepancy NNS cord-010092-uftc8inx 8846 10 and and CC cord-010092-uftc8inx 8846 11 their -PRON- PRP$ cord-010092-uftc8inx 8846 12 resolution resolution NN cord-010092-uftc8inx 8846 13 to to TO cord-010092-uftc8inx 8846 14 correctly correctly RB cord-010092-uftc8inx 8846 15 identify identify VB cord-010092-uftc8inx 8846 16 the the DT cord-010092-uftc8inx 8846 17 blood blood NN cord-010092-uftc8inx 8846 18 group group NN cord-010092-uftc8inx 8846 19 of of IN cord-010092-uftc8inx 8846 20 the the DT cord-010092-uftc8inx 8846 21 donors donor NNS cord-010092-uftc8inx 8846 22 . . . cord-010092-uftc8inx 8847 1 We -PRON- PRP cord-010092-uftc8inx 8847 2 also also RB cord-010092-uftc8inx 8847 3 determined determine VBD cord-010092-uftc8inx 8847 4 the the DT cord-010092-uftc8inx 8847 5 frequency frequency NN cord-010092-uftc8inx 8847 6 of of IN cord-010092-uftc8inx 8847 7 ' ' `` cord-010092-uftc8inx 8847 8 Weak Weak NNP cord-010092-uftc8inx 8847 9 D d NN cord-010092-uftc8inx 8847 10 ' ' '' cord-010092-uftc8inx 8847 11 positivity positivity NN cord-010092-uftc8inx 8847 12 in in IN cord-010092-uftc8inx 8847 13 RhD RhD NNP cord-010092-uftc8inx 8847 14 negative negative JJ cord-010092-uftc8inx 8847 15 donors donor NNS cord-010092-uftc8inx 8847 16 . . . cord-010092-uftc8inx 8848 1 Methods method NNS cord-010092-uftc8inx 8848 2 : : : cord-010092-uftc8inx 8848 3 This this DT cord-010092-uftc8inx 8848 4 was be VBD cord-010092-uftc8inx 8848 5 a a DT cord-010092-uftc8inx 8848 6 retrospective retrospective JJ cord-010092-uftc8inx 8848 7 study study NN cord-010092-uftc8inx 8848 8 on on IN cord-010092-uftc8inx 8848 9 donor donor NN cord-010092-uftc8inx 8848 10 samples sample NNS cord-010092-uftc8inx 8848 11 collected collect VBN cord-010092-uftc8inx 8848 12 from from IN cord-010092-uftc8inx 8848 13 1 1 CD cord-010092-uftc8inx 8848 14 st st NNP cord-010092-uftc8inx 8848 15 April April NNP cord-010092-uftc8inx 8848 16 , , , cord-010092-uftc8inx 8848 17 2013 2013 CD cord-010092-uftc8inx 8848 18 to to TO cord-010092-uftc8inx 8848 19 30 30 CD cord-010092-uftc8inx 8848 20 th th DT cord-010092-uftc8inx 8848 21 September September NNP cord-010092-uftc8inx 8848 22 , , , cord-010092-uftc8inx 8848 23 2015 2015 CD cord-010092-uftc8inx 8848 24 ( ( -LRB- cord-010092-uftc8inx 8848 25 two two CD cord-010092-uftc8inx 8848 26 and and CC cord-010092-uftc8inx 8848 27 a a DT cord-010092-uftc8inx 8848 28 half half NN cord-010092-uftc8inx 8848 29 years year NNS cord-010092-uftc8inx 8848 30 ) ) -RRB- cord-010092-uftc8inx 8848 31 . . . cord-010092-uftc8inx 8849 1 For for IN cord-010092-uftc8inx 8849 2 discrepant discrepant JJ cord-010092-uftc8inx 8849 3 samples sample NNS cord-010092-uftc8inx 8849 4 , , , cord-010092-uftc8inx 8849 5 the the DT cord-010092-uftc8inx 8849 6 ABO ABO NNP cord-010092-uftc8inx 8849 7 and and CC cord-010092-uftc8inx 8849 8 RhD RhD NNP cord-010092-uftc8inx 8849 9 grouping grouping NN cord-010092-uftc8inx 8849 10 was be VBD cord-010092-uftc8inx 8849 11 repeated repeat VBN cord-010092-uftc8inx 8849 12 using use VBG cord-010092-uftc8inx 8849 13 tube tube NN cord-010092-uftc8inx 8849 14 technique technique NN cord-010092-uftc8inx 8849 15 using use VBG cord-010092-uftc8inx 8849 16 commercial commercial JJ cord-010092-uftc8inx 8849 17 antisera antisera NN cord-010092-uftc8inx 8849 18 { { -LRB- cord-010092-uftc8inx 8849 19 anti anti NNP cord-010092-uftc8inx 8849 20 - - JJ cord-010092-uftc8inx 8849 21 A a JJ cord-010092-uftc8inx 8849 22 , , , cord-010092-uftc8inx 8849 23 anti anti NN cord-010092-uftc8inx 8849 24 - - NN cord-010092-uftc8inx 8849 25 B b JJ cord-010092-uftc8inx 8849 26 , , , cord-010092-uftc8inx 8849 27 anti anti JJ cord-010092-uftc8inx 8849 28 - - JJ cord-010092-uftc8inx 8849 29 AB ab JJ cord-010092-uftc8inx 8849 30 and and CC cord-010092-uftc8inx 8849 31 anti anti JJ cord-010092-uftc8inx 8849 32 - - JJ cord-010092-uftc8inx 8849 33 D d JJ cord-010092-uftc8inx 8849 34 ( ( -LRB- cord-010092-uftc8inx 8849 35 IgM IgM NNP cord-010092-uftc8inx 8849 36 ) ) -RRB- cord-010092-uftc8inx 8849 37 , , , cord-010092-uftc8inx 8849 38 anti anti JJ cord-010092-uftc8inx 8849 39 - - JJ cord-010092-uftc8inx 8849 40 D d JJ cord-010092-uftc8inx 8849 41 blend blend NN cord-010092-uftc8inx 8849 42 ( ( -LRB- cord-010092-uftc8inx 8849 43 IgM+IgG IgM+IgG NNP cord-010092-uftc8inx 8849 44 ) ) -RRB- cord-010092-uftc8inx 8849 45 , , , cord-010092-uftc8inx 8849 46 anti anti NNP cord-010092-uftc8inx 8849 47 - - NNP cord-010092-uftc8inx 8849 48 H h JJ cord-010092-uftc8inx 8849 49 and and CC cord-010092-uftc8inx 8849 50 anti anti JJ cord-010092-uftc8inx 8849 51 - - JJ cord-010092-uftc8inx 8849 52 A1 a1 JJ cord-010092-uftc8inx 8849 53 lectins lectin NNS cord-010092-uftc8inx 8849 54 } } -RRB- cord-010092-uftc8inx 8849 55 . . . cord-010092-uftc8inx 8850 1 Adsorption adsorption NN cord-010092-uftc8inx 8850 2 - - HYPH cord-010092-uftc8inx 8850 3 elution elution NN cord-010092-uftc8inx 8850 4 testing testing NN cord-010092-uftc8inx 8850 5 was be VBD cord-010092-uftc8inx 8850 6 done do VBN cord-010092-uftc8inx 8850 7 for for IN cord-010092-uftc8inx 8850 8 detecting detect VBG cord-010092-uftc8inx 8850 9 weak weak JJ cord-010092-uftc8inx 8850 10 subgroups subgroup NNS cord-010092-uftc8inx 8850 11 of of IN cord-010092-uftc8inx 8850 12 A A NNP cord-010092-uftc8inx 8850 13 and and CC cord-010092-uftc8inx 8850 14 B. B. NNP cord-010092-uftc8inx 8850 15 Antibody Antibody NNP cord-010092-uftc8inx 8850 16 screen screen NN cord-010092-uftc8inx 8850 17 ( ( -LRB- cord-010092-uftc8inx 8850 18 3-cell 3-cell CD cord-010092-uftc8inx 8850 19 ) ) -RRB- cord-010092-uftc8inx 8850 20 and and CC cord-010092-uftc8inx 8850 21 identification identification NN cord-010092-uftc8inx 8850 22 ( ( -LRB- cord-010092-uftc8inx 8850 23 11-cell 11-cell CD cord-010092-uftc8inx 8850 24 ) ) -RRB- cord-010092-uftc8inx 8850 25 was be VBD cord-010092-uftc8inx 8850 26 done do VBN cord-010092-uftc8inx 8850 27 by by IN cord-010092-uftc8inx 8850 28 gel gel NN cord-010092-uftc8inx 8850 29 technique technique NN cord-010092-uftc8inx 8850 30 ( ( -LRB- cord-010092-uftc8inx 8850 31 Bio Bio NNP cord-010092-uftc8inx 8850 32 - - HYPH cord-010092-uftc8inx 8850 33 Rad Rad NNP cord-010092-uftc8inx 8850 34 , , , cord-010092-uftc8inx 8850 35 Switzerland Switzerland NNP cord-010092-uftc8inx 8850 36 ) ) -RRB- cord-010092-uftc8inx 8850 37 . . . cord-010092-uftc8inx 8850 38 ' ' '' cord-010092-uftc8inx 8851 1 Weak Weak NNP cord-010092-uftc8inx 8851 2 D D NNP cord-010092-uftc8inx 8851 3 ' ' POS cord-010092-uftc8inx 8851 4 testing testing NN cord-010092-uftc8inx 8851 5 in in IN cord-010092-uftc8inx 8851 6 RhD RhD NNP cord-010092-uftc8inx 8852 1 negative negative JJ cord-010092-uftc8inx 8852 2 donors donor NNS cord-010092-uftc8inx 8852 3 was be VBD cord-010092-uftc8inx 8852 4 also also RB cord-010092-uftc8inx 8852 5 performed perform VBN cord-010092-uftc8inx 8852 6 by by IN cord-010092-uftc8inx 8852 7 gel gel NN cord-010092-uftc8inx 8852 8 technique technique NN cord-010092-uftc8inx 8852 9 . . . cord-010092-uftc8inx 8853 1 Antibody antibody NN cord-010092-uftc8inx 8853 2 titration titration NN cord-010092-uftc8inx 8853 3 was be VBD cord-010092-uftc8inx 8853 4 done do VBN cord-010092-uftc8inx 8853 5 using use VBG cord-010092-uftc8inx 8853 6 tube tube NN cord-010092-uftc8inx 8853 7 technique technique NN cord-010092-uftc8inx 8853 8 . . . cord-010092-uftc8inx 8854 1 The the DT cord-010092-uftc8inx 8854 2 donor donor NN cord-010092-uftc8inx 8854 3 details detail NNS cord-010092-uftc8inx 8854 4 including include VBG cord-010092-uftc8inx 8854 5 name name NN cord-010092-uftc8inx 8854 6 , , , cord-010092-uftc8inx 8854 7 age age NN cord-010092-uftc8inx 8854 8 and and CC cord-010092-uftc8inx 8854 9 the the DT cord-010092-uftc8inx 8854 10 registration registration NN cord-010092-uftc8inx 8854 11 / / SYM cord-010092-uftc8inx 8854 12 unit unit NN cord-010092-uftc8inx 8854 13 number number NN cord-010092-uftc8inx 8854 14 of of IN cord-010092-uftc8inx 8854 15 the the DT cord-010092-uftc8inx 8854 16 donation donation NN cord-010092-uftc8inx 8854 17 were be VBD cord-010092-uftc8inx 8854 18 also also RB cord-010092-uftc8inx 8854 19 checked check VBN cord-010092-uftc8inx 8854 20 for for IN cord-010092-uftc8inx 8854 21 all all PDT cord-010092-uftc8inx 8854 22 the the DT cord-010092-uftc8inx 8854 23 discrepancies discrepancy NNS cord-010092-uftc8inx 8854 24 to to TO cord-010092-uftc8inx 8854 25 avoid avoid VB cord-010092-uftc8inx 8854 26 repetition repetition NN cord-010092-uftc8inx 8854 27 while while IN cord-010092-uftc8inx 8854 28 data datum NNS cord-010092-uftc8inx 8854 29 analysis analysis NN cord-010092-uftc8inx 8854 30 . . . cord-010092-uftc8inx 8855 1 Results result NNS cord-010092-uftc8inx 8855 2 : : : cord-010092-uftc8inx 8856 1 We -PRON- PRP cord-010092-uftc8inx 8856 2 detected detect VBD cord-010092-uftc8inx 8856 3 104 104 CD cord-010092-uftc8inx 8856 4 ( ( -LRB- cord-010092-uftc8inx 8856 5 0.072 0.072 CD cord-010092-uftc8inx 8856 6 % % NN cord-010092-uftc8inx 8856 7 ) ) -RRB- cord-010092-uftc8inx 8857 1 ABO ABO NNP cord-010092-uftc8inx 8857 2 discrepancies discrepancy NNS cord-010092-uftc8inx 8857 3 out out IN cord-010092-uftc8inx 8857 4 of of IN cord-010092-uftc8inx 8857 5 the the DT cord-010092-uftc8inx 8857 6 total total JJ cord-010092-uftc8inx 8857 7 144279 144279 CD cord-010092-uftc8inx 8857 8 donor donor NN cord-010092-uftc8inx 8857 9 samples sample NNS cord-010092-uftc8inx 8857 10 tested test VBN cord-010092-uftc8inx 8857 11 during during IN cord-010092-uftc8inx 8857 12 the the DT cord-010092-uftc8inx 8857 13 study study NN cord-010092-uftc8inx 8857 14 period period NN cord-010092-uftc8inx 8857 15 . . . cord-010092-uftc8inx 8858 1 Out out IN cord-010092-uftc8inx 8858 2 of of IN cord-010092-uftc8inx 8858 3 these these DT cord-010092-uftc8inx 8858 4 , , , cord-010092-uftc8inx 8858 5 135043 135043 CD cord-010092-uftc8inx 8858 6 ( ( -LRB- cord-010092-uftc8inx 8858 7 93.6 93.6 CD cord-010092-uftc8inx 8858 8 % % NN cord-010092-uftc8inx 8858 9 ) ) -RRB- cord-010092-uftc8inx 8858 10 were be VBD cord-010092-uftc8inx 8858 11 RhD RhD NNP cord-010092-uftc8inx 8858 12 positive positive JJ cord-010092-uftc8inx 8858 13 . . . cord-010092-uftc8inx 8859 1 The the DT cord-010092-uftc8inx 8859 2 most most RBS cord-010092-uftc8inx 8859 3 common common JJ cord-010092-uftc8inx 8859 4 cause cause NN cord-010092-uftc8inx 8859 5 of of IN cord-010092-uftc8inx 8859 6 ABO ABO NNP cord-010092-uftc8inx 8859 7 discrepancies discrepancy NNS cord-010092-uftc8inx 8859 8 was be VBD cord-010092-uftc8inx 8859 9 weak weak JJ cord-010092-uftc8inx 8859 10 anti anti JJ cord-010092-uftc8inx 8859 11 - - JJ cord-010092-uftc8inx 8859 12 B b JJ cord-010092-uftc8inx 8859 13 antibody antibody NN cord-010092-uftc8inx 8859 14 ( ( -LRB- cord-010092-uftc8inx 8859 15 33/104 33/104 CD cord-010092-uftc8inx 8859 16 ; ; : cord-010092-uftc8inx 8859 17 31.73 31.73 CD cord-010092-uftc8inx 8859 18 % % NN cord-010092-uftc8inx 8859 19 ) ) -RRB- cord-010092-uftc8inx 8859 20 , , , cord-010092-uftc8inx 8859 21 followed follow VBN cord-010092-uftc8inx 8859 22 by by IN cord-010092-uftc8inx 8859 23 weak weak JJ cord-010092-uftc8inx 8859 24 anti anti JJ cord-010092-uftc8inx 8859 25 - - JJ cord-010092-uftc8inx 8859 26 A a DT cord-010092-uftc8inx 8859 27 antibody antibody NN cord-010092-uftc8inx 8859 28 and and CC cord-010092-uftc8inx 8859 29 weak weak JJ cord-010092-uftc8inx 8859 30 subgroups subgroup NNS cord-010092-uftc8inx 8859 31 of of IN cord-010092-uftc8inx 8859 32 A a NN cord-010092-uftc8inx 8859 33 ( ( -LRB- cord-010092-uftc8inx 8859 34 24/104 24/104 CD cord-010092-uftc8inx 8859 35 each each DT cord-010092-uftc8inx 8859 36 ; ; : cord-010092-uftc8inx 8859 37 23.07 23.07 CD cord-010092-uftc8inx 8859 38 % % NN cord-010092-uftc8inx 8859 39 each each DT cord-010092-uftc8inx 8859 40 ) ) -RRB- cord-010092-uftc8inx 8859 41 and and CC cord-010092-uftc8inx 8859 42 weak weak JJ cord-010092-uftc8inx 8859 43 subgroups subgroup NNS cord-010092-uftc8inx 8859 44 of of IN cord-010092-uftc8inx 8859 45 B b NN cord-010092-uftc8inx 8859 46 ( ( -LRB- cord-010092-uftc8inx 8859 47 5/104 5/104 CD cord-010092-uftc8inx 8859 48 ; ; : cord-010092-uftc8inx 8859 49 4.8 4.8 CD cord-010092-uftc8inx 8859 50 % % NN cord-010092-uftc8inx 8859 51 ) ) -RRB- cord-010092-uftc8inx 8859 52 . . . cord-010092-uftc8inx 8860 1 The the DT cord-010092-uftc8inx 8860 2 remaining remain VBG cord-010092-uftc8inx 8860 3 17.3 17.3 CD cord-010092-uftc8inx 8860 4 % % NN cord-010092-uftc8inx 8860 5 ( ( -LRB- cord-010092-uftc8inx 8860 6 18/104 18/104 CD cord-010092-uftc8inx 8860 7 ) ) -RRB- cord-010092-uftc8inx 8860 8 discrepancies discrepancy NNS cord-010092-uftc8inx 8860 9 were be VBD cord-010092-uftc8inx 8860 10 due due JJ cord-010092-uftc8inx 8860 11 to to IN cord-010092-uftc8inx 8860 12 agglutination agglutination NN cord-010092-uftc8inx 8860 13 with with IN cord-010092-uftc8inx 8860 14 O o NN cord-010092-uftc8inx 8860 15 cells cell NNS cord-010092-uftc8inx 8860 16 in in IN cord-010092-uftc8inx 8860 17 reverse reverse JJ cord-010092-uftc8inx 8860 18 grouping grouping NN cord-010092-uftc8inx 8860 19 . . . cord-010092-uftc8inx 8861 1 The the DT cord-010092-uftc8inx 8861 2 overall overall JJ cord-010092-uftc8inx 8861 3 frequency frequency NN cord-010092-uftc8inx 8861 4 of of IN cord-010092-uftc8inx 8861 5 weak weak JJ cord-010092-uftc8inx 8861 6 subgroups subgroup NNS cord-010092-uftc8inx 8861 7 of of IN cord-010092-uftc8inx 8861 8 A a NN cord-010092-uftc8inx 8861 9 and and CC cord-010092-uftc8inx 8861 10 B b NN cord-010092-uftc8inx 8861 11 collectively collectively RB cord-010092-uftc8inx 8861 12 was be VBD cord-010092-uftc8inx 8861 13 0.02 0.02 CD cord-010092-uftc8inx 8861 14 % % NN cord-010092-uftc8inx 8862 1 ( ( -LRB- cord-010092-uftc8inx 8862 2 Background background NN cord-010092-uftc8inx 8862 3 : : : cord-010092-uftc8inx 8863 1 Detection detection NN cord-010092-uftc8inx 8863 2 of of IN cord-010092-uftc8inx 8863 3 unexpected unexpected JJ cord-010092-uftc8inx 8863 4 red red JJ cord-010092-uftc8inx 8863 5 blood blood NN cord-010092-uftc8inx 8863 6 cell cell NN cord-010092-uftc8inx 8863 7 ( ( -LRB- cord-010092-uftc8inx 8863 8 RBC RBC NNP cord-010092-uftc8inx 8863 9 ) ) -RRB- cord-010092-uftc8inx 8863 10 antibodies antibody NNS cord-010092-uftc8inx 8863 11 before before IN cord-010092-uftc8inx 8863 12 transfusion transfusion NN cord-010092-uftc8inx 8863 13 is be VBZ cord-010092-uftc8inx 8863 14 critical critical JJ cord-010092-uftc8inx 8863 15 for for IN cord-010092-uftc8inx 8863 16 prevention prevention NN cord-010092-uftc8inx 8863 17 of of IN cord-010092-uftc8inx 8863 18 hemolytic hemolytic JJ cord-010092-uftc8inx 8863 19 transfusion transfusion NN cord-010092-uftc8inx 8863 20 reaction reaction NN cord-010092-uftc8inx 8863 21 . . . cord-010092-uftc8inx 8864 1 Ideally ideally RB cord-010092-uftc8inx 8864 2 , , , cord-010092-uftc8inx 8864 3 unexpected unexpected JJ cord-010092-uftc8inx 8864 4 RBC RBC NNP cord-010092-uftc8inx 8864 5 antibody antibody NN cord-010092-uftc8inx 8864 6 detection detection NN cord-010092-uftc8inx 8864 7 is be VBZ cord-010092-uftc8inx 8864 8 carried carry VBN cord-010092-uftc8inx 8864 9 out out RP cord-010092-uftc8inx 8864 10 within within IN cord-010092-uftc8inx 8864 11 3 3 CD cord-010092-uftc8inx 8864 12 days day NNS cord-010092-uftc8inx 8864 13 after after IN cord-010092-uftc8inx 8864 14 receiving receive VBG cord-010092-uftc8inx 8864 15 a a DT cord-010092-uftc8inx 8864 16 patient patient NN cord-010092-uftc8inx 8864 17 's 's POS cord-010092-uftc8inx 8864 18 sample sample NN cord-010092-uftc8inx 8864 19 . . . cord-010092-uftc8inx 8865 1 However however RB cord-010092-uftc8inx 8865 2 , , , cord-010092-uftc8inx 8865 3 in in IN cord-010092-uftc8inx 8865 4 some some DT cord-010092-uftc8inx 8865 5 cases case NNS cord-010092-uftc8inx 8865 6 , , , cord-010092-uftc8inx 8865 7 retests retest NNS cord-010092-uftc8inx 8865 8 could could MD cord-010092-uftc8inx 8865 9 be be VB cord-010092-uftc8inx 8865 10 performed perform VBN cord-010092-uftc8inx 8865 11 after after IN cord-010092-uftc8inx 8865 12 more more JJR cord-010092-uftc8inx 8865 13 than than IN cord-010092-uftc8inx 8865 14 3 3 CD cord-010092-uftc8inx 8865 15 days day NNS cord-010092-uftc8inx 8865 16 for for IN cord-010092-uftc8inx 8865 17 evaluation evaluation NN cord-010092-uftc8inx 8865 18 of of IN cord-010092-uftc8inx 8865 19 any any DT cord-010092-uftc8inx 8865 20 transfusion transfusion NN cord-010092-uftc8inx 8865 21 reaction reaction NN cord-010092-uftc8inx 8865 22 , , , cord-010092-uftc8inx 8865 23 quality quality NN cord-010092-uftc8inx 8865 24 control control NN cord-010092-uftc8inx 8865 25 or or CC cord-010092-uftc8inx 8865 26 research research NN cord-010092-uftc8inx 8865 27 . . . cord-010092-uftc8inx 8866 1 Therefore therefore RB cord-010092-uftc8inx 8866 2 , , , cord-010092-uftc8inx 8866 3 it -PRON- PRP cord-010092-uftc8inx 8866 4 is be VBZ cord-010092-uftc8inx 8866 5 necessary necessary JJ cord-010092-uftc8inx 8866 6 to to TO cord-010092-uftc8inx 8866 7 determine determine VB cord-010092-uftc8inx 8866 8 the the DT cord-010092-uftc8inx 8866 9 stability stability NN cord-010092-uftc8inx 8866 10 of of IN cord-010092-uftc8inx 8866 11 antibodies antibody NNS cord-010092-uftc8inx 8866 12 after after IN cord-010092-uftc8inx 8866 13 refrigeration refrigeration NN cord-010092-uftc8inx 8866 14 or or CC cord-010092-uftc8inx 8866 15 freezing freeze VBG cord-010092-uftc8inx 8866 16 for for IN cord-010092-uftc8inx 8866 17 a a DT cord-010092-uftc8inx 8866 18 certain certain JJ cord-010092-uftc8inx 8866 19 period period NN cord-010092-uftc8inx 8866 20 of of IN cord-010092-uftc8inx 8866 21 time time NN cord-010092-uftc8inx 8866 22 . . . cord-010092-uftc8inx 8867 1 Aims aim VBZ cord-010092-uftc8inx 8867 2 : : : cord-010092-uftc8inx 8868 1 We -PRON- PRP cord-010092-uftc8inx 8868 2 carried carry VBD cord-010092-uftc8inx 8868 3 out out RP cord-010092-uftc8inx 8868 4 antibody antibody NN cord-010092-uftc8inx 8868 5 identification identification NN cord-010092-uftc8inx 8868 6 test test NN cord-010092-uftc8inx 8868 7 with with IN cord-010092-uftc8inx 8868 8 fresh fresh JJ cord-010092-uftc8inx 8868 9 , , , cord-010092-uftc8inx 8868 10 refrigerated refrigerated JJ cord-010092-uftc8inx 8868 11 and and CC cord-010092-uftc8inx 8868 12 frozen frozen JJ cord-010092-uftc8inx 8868 13 samples sample NNS cord-010092-uftc8inx 8868 14 using use VBG cord-010092-uftc8inx 8868 15 automated automate VBN cord-010092-uftc8inx 8868 16 analyzer analyzer NN cord-010092-uftc8inx 8868 17 IH-500 IH-500 NNP cord-010092-uftc8inx 8868 18 and and CC cord-010092-uftc8inx 8868 19 manual manual JJ cord-010092-uftc8inx 8868 20 tube tube NN cord-010092-uftc8inx 8868 21 methods method NNS cord-010092-uftc8inx 8868 22 to to TO cord-010092-uftc8inx 8868 23 evaluate evaluate VB cord-010092-uftc8inx 8868 24 the the DT cord-010092-uftc8inx 8868 25 stability stability NN cord-010092-uftc8inx 8868 26 of of IN cord-010092-uftc8inx 8868 27 antibodies antibody NNS cord-010092-uftc8inx 8868 28 after after IN cord-010092-uftc8inx 8868 29 storage storage NN cord-010092-uftc8inx 8868 30 and and CC cord-010092-uftc8inx 8868 31 compare compare VB cord-010092-uftc8inx 8868 32 the the DT cord-010092-uftc8inx 8868 33 results result NNS cord-010092-uftc8inx 8868 34 between between IN cord-010092-uftc8inx 8868 35 the the DT cord-010092-uftc8inx 8868 36 two two CD cord-010092-uftc8inx 8868 37 methods method NNS cord-010092-uftc8inx 8868 38 Methods method NNS cord-010092-uftc8inx 8868 39 : : : cord-010092-uftc8inx 8868 40 Antibody antibody NN cord-010092-uftc8inx 8868 41 identification identification NN cord-010092-uftc8inx 8868 42 tests test NNS cord-010092-uftc8inx 8868 43 were be VBD cord-010092-uftc8inx 8868 44 performed perform VBN cord-010092-uftc8inx 8868 45 using use VBG cord-010092-uftc8inx 8869 1 IH-500 IH-500 VBG cord-010092-uftc8inx 8869 2 ( ( -LRB- cord-010092-uftc8inx 8869 3 Bio Bio NNP cord-010092-uftc8inx 8869 4 - - HYPH cord-010092-uftc8inx 8869 5 rad rad NNP cord-010092-uftc8inx 8869 6 , , , cord-010092-uftc8inx 8869 7 1785 1785 CD cord-010092-uftc8inx 8869 8 Cressier Cressier NNP cord-010092-uftc8inx 8869 9 FR FR NNP cord-010092-uftc8inx 8869 10 , , , cord-010092-uftc8inx 8869 11 Switzerland Switzerland NNP cord-010092-uftc8inx 8869 12 ) ) -RRB- cord-010092-uftc8inx 8869 13 and and CC cord-010092-uftc8inx 8869 14 manual manual JJ cord-010092-uftc8inx 8869 15 tube tube NN cord-010092-uftc8inx 8869 16 methods method NNS cord-010092-uftc8inx 8869 17 . . . cord-010092-uftc8inx 8870 1 Fifty fifty CD cord-010092-uftc8inx 8870 2 samples sample NNS cord-010092-uftc8inx 8870 3 showing show VBG cord-010092-uftc8inx 8870 4 positive positive JJ cord-010092-uftc8inx 8870 5 results result NNS cord-010092-uftc8inx 8870 6 in in IN cord-010092-uftc8inx 8870 7 antibody antibody NN cord-010092-uftc8inx 8870 8 screening screening NN cord-010092-uftc8inx 8870 9 test test NN cord-010092-uftc8inx 8870 10 by by IN cord-010092-uftc8inx 8870 11 both both DT cord-010092-uftc8inx 8870 12 methods method NNS cord-010092-uftc8inx 8870 13 were be VBD cord-010092-uftc8inx 8870 14 divided divide VBN cord-010092-uftc8inx 8870 15 into into IN cord-010092-uftc8inx 8870 16 three three CD cord-010092-uftc8inx 8870 17 and and CC cord-010092-uftc8inx 8870 18 tested test VBN cord-010092-uftc8inx 8870 19 immediately immediately RB cord-010092-uftc8inx 8870 20 , , , cord-010092-uftc8inx 8870 21 1 1 CD cord-010092-uftc8inx 8870 22 week week NN cord-010092-uftc8inx 8870 23 after after IN cord-010092-uftc8inx 8870 24 storage storage NN cord-010092-uftc8inx 8870 25 at at IN cord-010092-uftc8inx 8870 26 4 4 CD cord-010092-uftc8inx 8870 27 ° ° NN cord-010092-uftc8inx 8870 28 C c NN cord-010092-uftc8inx 8870 29 and and CC cord-010092-uftc8inx 8870 30 1 1 CD cord-010092-uftc8inx 8870 31 month month NN cord-010092-uftc8inx 8870 32 after after IN cord-010092-uftc8inx 8870 33 storage storage NN cord-010092-uftc8inx 8870 34 at at IN cord-010092-uftc8inx 8870 35 À20 À20 NNP cord-010092-uftc8inx 8870 36 ° ° NN cord-010092-uftc8inx 8870 37 C c NN cord-010092-uftc8inx 8870 38 . . . cord-010092-uftc8inx 8871 1 The the DT cord-010092-uftc8inx 8871 2 specificities specificity NNS cord-010092-uftc8inx 8871 3 and and CC cord-010092-uftc8inx 8871 4 reactivities reactivity NNS cord-010092-uftc8inx 8871 5 of of IN cord-010092-uftc8inx 8871 6 antibodies antibody NNS cord-010092-uftc8inx 8871 7 at at IN cord-010092-uftc8inx 8871 8 each each DT cord-010092-uftc8inx 8871 9 storage storage NN cord-010092-uftc8inx 8871 10 state state NN cord-010092-uftc8inx 8871 11 were be VBD cord-010092-uftc8inx 8871 12 recorded record VBN cord-010092-uftc8inx 8871 13 and and CC cord-010092-uftc8inx 8871 14 compared compare VBN cord-010092-uftc8inx 8871 15 between between IN cord-010092-uftc8inx 8871 16 the the DT cord-010092-uftc8inx 8871 17 two two CD cord-010092-uftc8inx 8871 18 methods method NNS cord-010092-uftc8inx 8871 19 . . . cord-010092-uftc8inx 8872 1 Results result NNS cord-010092-uftc8inx 8872 2 : : : cord-010092-uftc8inx 8873 1 Specificities specificity NNS cord-010092-uftc8inx 8873 2 of of IN cord-010092-uftc8inx 8873 3 antibodies antibody NNS cord-010092-uftc8inx 8873 4 identified identify VBN cord-010092-uftc8inx 8873 5 were be VBD cord-010092-uftc8inx 8873 6 concordant concordant JJ cord-010092-uftc8inx 8873 7 between between IN cord-010092-uftc8inx 8873 8 IH-500 IH-500 NNP cord-010092-uftc8inx 8873 9 and and CC cord-010092-uftc8inx 8873 10 manual manual JJ cord-010092-uftc8inx 8873 11 tube tube NN cord-010092-uftc8inx 8873 12 methods method NNS cord-010092-uftc8inx 8873 13 irrespective irrespective RB cord-010092-uftc8inx 8873 14 of of IN cord-010092-uftc8inx 8873 15 the the DT cord-010092-uftc8inx 8873 16 storage storage NN cord-010092-uftc8inx 8873 17 state state NN cord-010092-uftc8inx 8873 18 . . . cord-010092-uftc8inx 8874 1 The the DT cord-010092-uftc8inx 8874 2 results result NNS cord-010092-uftc8inx 8874 3 were be VBD cord-010092-uftc8inx 8874 4 as as IN cord-010092-uftc8inx 8874 5 follows follow VBZ cord-010092-uftc8inx 8874 6 : : : cord-010092-uftc8inx 8875 1 anti anti JJ cord-010092-uftc8inx 8875 2 - - JJ cord-010092-uftc8inx 8875 3 E e JJ cord-010092-uftc8inx 8875 4 / / SYM cord-010092-uftc8inx 8875 5 E+c E+c NNP cord-010092-uftc8inx 8875 6 , , , cord-010092-uftc8inx 8875 7 15 15 CD cord-010092-uftc8inx 8875 8 ; ; : cord-010092-uftc8inx 8875 9 anti anti JJ cord-010092-uftc8inx 8875 10 - - NNP cord-010092-uftc8inx 8875 11 Le Le NNP cord-010092-uftc8inx 8875 12 a a NNP cord-010092-uftc8inx 8875 13 , , , cord-010092-uftc8inx 8875 14 4 4 CD cord-010092-uftc8inx 8875 15 ; ; : cord-010092-uftc8inx 8875 16 anti anti JJ cord-010092-uftc8inx 8875 17 - - JJ cord-010092-uftc8inx 8875 18 Di Di NNP cord-010092-uftc8inx 8875 19 a a NN cord-010092-uftc8inx 8875 20 , , , cord-010092-uftc8inx 8875 21 4 4 CD cord-010092-uftc8inx 8875 22 ; ; : cord-010092-uftc8inx 8875 23 anti anti JJ cord-010092-uftc8inx 8875 24 - - JJ cord-010092-uftc8inx 8875 25 C+e c+e JJ cord-010092-uftc8inx 8875 26 , , , cord-010092-uftc8inx 8875 27 3 3 CD cord-010092-uftc8inx 8875 28 ; ; : cord-010092-uftc8inx 8875 29 anti anti NNP cord-010092-uftc8inx 8875 30 - - NNP cord-010092-uftc8inx 8875 31 M M NNP cord-010092-uftc8inx 8875 32 , , , cord-010092-uftc8inx 8875 33 3 3 CD cord-010092-uftc8inx 8875 34 ; ; : cord-010092-uftc8inx 8875 35 anti anti JJ cord-010092-uftc8inx 8875 36 - - JJ cord-010092-uftc8inx 8875 37 D d JJ cord-010092-uftc8inx 8875 38 , , , cord-010092-uftc8inx 8875 39 2 2 CD cord-010092-uftc8inx 8875 40 ; ; : cord-010092-uftc8inx 8875 41 anti anti JJ cord-010092-uftc8inx 8875 42 - - JJ cord-010092-uftc8inx 8875 43 C C NNP cord-010092-uftc8inx 8875 44 , , , cord-010092-uftc8inx 8875 45 1 1 CD cord-010092-uftc8inx 8875 46 ; ; : cord-010092-uftc8inx 8875 47 anti anti JJ cord-010092-uftc8inx 8875 48 - - JJ cord-010092-uftc8inx 8875 49 K k JJ cord-010092-uftc8inx 8875 50 , , , cord-010092-uftc8inx 8875 51 1 1 CD cord-010092-uftc8inx 8875 52 ; ; : cord-010092-uftc8inx 8875 53 anti anti NNP cord-010092-uftc8inx 8875 54 - - NN cord-010092-uftc8inx 8875 55 Jk Jk NNP cord-010092-uftc8inx 8875 56 a a NN cord-010092-uftc8inx 8875 57 , , , cord-010092-uftc8inx 8875 58 1 1 CD cord-010092-uftc8inx 8875 59 : : : cord-010092-uftc8inx 8875 60 anti anti NNP cord-010092-uftc8inx 8875 61 - - NNP cord-010092-uftc8inx 8875 62 Xg Xg NNP cord-010092-uftc8inx 8875 63 a a DT cord-010092-uftc8inx 8875 64 , , , cord-010092-uftc8inx 8875 65 1 1 CD cord-010092-uftc8inx 8875 66 ; ; , cord-010092-uftc8inx 8875 67 unidentified unidentified JJ cord-010092-uftc8inx 8875 68 antibody antibody NN cord-010092-uftc8inx 8875 69 , , , cord-010092-uftc8inx 8875 70 13 13 CD cord-010092-uftc8inx 8875 71 ; ; : cord-010092-uftc8inx 8875 72 autoantibody autoantibody NNP cord-010092-uftc8inx 8875 73 , , , cord-010092-uftc8inx 8875 74 2 2 CD cord-010092-uftc8inx 8875 75 cases case NNS cord-010092-uftc8inx 8875 76 . . . cord-010092-uftc8inx 8876 1 With with IN cord-010092-uftc8inx 8876 2 regard regard NN cord-010092-uftc8inx 8876 3 to to IN cord-010092-uftc8inx 8876 4 the the DT cord-010092-uftc8inx 8876 5 changes change NNS cord-010092-uftc8inx 8876 6 in in IN cord-010092-uftc8inx 8876 7 reactivity reactivity NN cord-010092-uftc8inx 8876 8 owing owe VBG cord-010092-uftc8inx 8876 9 to to IN cord-010092-uftc8inx 8876 10 storage storage NN cord-010092-uftc8inx 8876 11 , , , cord-010092-uftc8inx 8876 12 26 26 CD cord-010092-uftc8inx 8876 13 ( ( -LRB- cord-010092-uftc8inx 8876 14 52 52 CD cord-010092-uftc8inx 8876 15 % % NN cord-010092-uftc8inx 8876 16 ) ) -RRB- cord-010092-uftc8inx 8876 17 samples sample NNS cord-010092-uftc8inx 8876 18 ( ( -LRB- cord-010092-uftc8inx 8876 19 anti anti JJ cord-010092-uftc8inx 8876 20 - - JJ cord-010092-uftc8inx 8876 21 E+c e+c JJ cord-010092-uftc8inx 8876 22 , , , cord-010092-uftc8inx 8876 23 12 12 CD cord-010092-uftc8inx 8876 24 ; ; : cord-010092-uftc8inx 8876 25 anti anti JJ cord-010092-uftc8inx 8876 26 - - NNP cord-010092-uftc8inx 8876 27 M M NNP cord-010092-uftc8inx 8876 28 , , , cord-010092-uftc8inx 8876 29 3 3 CD cord-010092-uftc8inx 8876 30 ; ; : cord-010092-uftc8inx 8876 31 anti anti JJ cord-010092-uftc8inx 8876 32 - - JJ cord-010092-uftc8inx 8876 33 Di Di NNP cord-010092-uftc8inx 8876 34 a a NN cord-010092-uftc8inx 8876 35 , , , cord-010092-uftc8inx 8876 36 3 3 CD cord-010092-uftc8inx 8876 37 ; ; : cord-010092-uftc8inx 8876 38 anti anti JJ cord-010092-uftc8inx 8876 39 - - JJ cord-010092-uftc8inx 8876 40 D d JJ cord-010092-uftc8inx 8876 41 , , , cord-010092-uftc8inx 8876 42 2 2 CD cord-010092-uftc8inx 8876 43 ; ; : cord-010092-uftc8inx 8876 44 anti anti JJ cord-010092-uftc8inx 8876 45 - - JJ cord-010092-uftc8inx 8876 46 C+e c+e JJ cord-010092-uftc8inx 8876 47 , , , cord-010092-uftc8inx 8876 48 2 2 CD cord-010092-uftc8inx 8876 49 ; ; : cord-010092-uftc8inx 8876 50 anti anti JJ cord-010092-uftc8inx 8876 51 - - NNP cord-010092-uftc8inx 8876 52 Le Le NNP cord-010092-uftc8inx 8876 53 a a NNP cord-010092-uftc8inx 8876 54 , , , cord-010092-uftc8inx 8876 55 1 1 CD cord-010092-uftc8inx 8876 56 ; ; : cord-010092-uftc8inx 8876 57 anti anti JJ cord-010092-uftc8inx 8876 58 - - NNP cord-010092-uftc8inx 8876 59 C C NNP cord-010092-uftc8inx 8876 60 , , , cord-010092-uftc8inx 8876 61 1 1 CD cord-010092-uftc8inx 8876 62 : : : cord-010092-uftc8inx 8876 63 autoantibody autoantibody NNP cord-010092-uftc8inx 8876 64 , , , cord-010092-uftc8inx 8876 65 1 1 CD cord-010092-uftc8inx 8876 66 ; ; , cord-010092-uftc8inx 8876 67 unidentified unidentified JJ cord-010092-uftc8inx 8876 68 antibody antibody NN cord-010092-uftc8inx 8876 69 , , , cord-010092-uftc8inx 8876 70 1 1 CD cord-010092-uftc8inx 8876 71 ) ) -RRB- cord-010092-uftc8inx 8876 72 showed show VBD cord-010092-uftc8inx 8876 73 identical identical JJ cord-010092-uftc8inx 8876 74 reactivities reactivity NNS cord-010092-uftc8inx 8876 75 after after IN cord-010092-uftc8inx 8876 76 1 1 CD cord-010092-uftc8inx 8876 77 week week NN cord-010092-uftc8inx 8876 78 and and CC cord-010092-uftc8inx 8876 79 1 1 CD cord-010092-uftc8inx 8876 80 month month NN cord-010092-uftc8inx 8876 81 storage storage NN cord-010092-uftc8inx 8876 82 by by IN cord-010092-uftc8inx 8876 83 both both CC cord-010092-uftc8inx 8876 84 IH-500 IH-500 NNP cord-010092-uftc8inx 8876 85 and and CC cord-010092-uftc8inx 8876 86 tube tube NN cord-010092-uftc8inx 8876 87 methods method NNS cord-010092-uftc8inx 8876 88 . . . cord-010092-uftc8inx 8877 1 However however RB cord-010092-uftc8inx 8877 2 , , , cord-010092-uftc8inx 8877 3 19 19 CD cord-010092-uftc8inx 8877 4 ( ( -LRB- cord-010092-uftc8inx 8877 5 38 38 CD cord-010092-uftc8inx 8877 6 % % NN cord-010092-uftc8inx 8877 7 ) ) -RRB- cord-010092-uftc8inx 8877 8 samples sample NNS cord-010092-uftc8inx 8877 9 , , , cord-010092-uftc8inx 8877 10 comprising comprise VBG cord-010092-uftc8inx 8877 11 12 12 CD cord-010092-uftc8inx 8877 12 unidentified unidentified JJ cord-010092-uftc8inx 8877 13 antibodies antibody NNS cord-010092-uftc8inx 8877 14 , , , cord-010092-uftc8inx 8877 15 3 3 CD cord-010092-uftc8inx 8877 16 anti anti JJ cord-010092-uftc8inx 8877 17 - - NNP cord-010092-uftc8inx 8877 18 Le Le NNP cord-010092-uftc8inx 8877 19 a a NNP cord-010092-uftc8inx 8877 20 , , , cord-010092-uftc8inx 8877 21 1 1 CD cord-010092-uftc8inx 8877 22 anti anti JJ cord-010092-uftc8inx 8877 23 - - JJ cord-010092-uftc8inx 8877 24 C+e c+e JJ cord-010092-uftc8inx 8877 25 , , , cord-010092-uftc8inx 8877 26 1 1 CD cord-010092-uftc8inx 8877 27 anti anti JJ cord-010092-uftc8inx 8877 28 - - JJ cord-010092-uftc8inx 8877 29 E e JJ cord-010092-uftc8inx 8877 30 , , , cord-010092-uftc8inx 8877 31 1 1 CD cord-010092-uftc8inx 8877 32 anti anti JJ cord-010092-uftc8inx 8877 33 - - JJ cord-010092-uftc8inx 8877 34 E+c e+c JJ cord-010092-uftc8inx 8877 35 , , , cord-010092-uftc8inx 8877 36 and and CC cord-010092-uftc8inx 8877 37 1 1 CD cord-010092-uftc8inx 8877 38 autoantibody autoantibody NNP cord-010092-uftc8inx 8877 39 , , , cord-010092-uftc8inx 8877 40 showed show VBD cord-010092-uftc8inx 8877 41 decreased decrease VBD cord-010092-uftc8inx 8877 42 reactivities reactivity NNS cord-010092-uftc8inx 8877 43 after after IN cord-010092-uftc8inx 8877 44 storage storage NN cord-010092-uftc8inx 8877 45 in in IN cord-010092-uftc8inx 8877 46 both both DT cord-010092-uftc8inx 8877 47 methods method NNS cord-010092-uftc8inx 8877 48 . . . cord-010092-uftc8inx 8878 1 Three three CD cord-010092-uftc8inx 8878 2 samples sample NNS cord-010092-uftc8inx 8878 3 , , , cord-010092-uftc8inx 8878 4 comprising comprise VBG cord-010092-uftc8inx 8878 5 anti anti JJ cord-010092-uftc8inx 8878 6 - - NNP cord-010092-uftc8inx 8878 7 Di Di NNP cord-010092-uftc8inx 8878 8 a a DT cord-010092-uftc8inx 8878 9 , , , cord-010092-uftc8inx 8878 10 anti anti JJ cord-010092-uftc8inx 8878 11 - - JJ cord-010092-uftc8inx 8878 12 E+c e+c JJ cord-010092-uftc8inx 8878 13 and and CC cord-010092-uftc8inx 8878 14 anti anti JJ cord-010092-uftc8inx 8878 15 - - JJ cord-010092-uftc8inx 8878 16 K k JJ cord-010092-uftc8inx 8878 17 antibodies antibody NNS cord-010092-uftc8inx 8878 18 , , , cord-010092-uftc8inx 8878 19 showed show VBD cord-010092-uftc8inx 8878 20 increased increase VBN cord-010092-uftc8inx 8878 21 reactivities reactivity NNS cord-010092-uftc8inx 8878 22 after after IN cord-010092-uftc8inx 8878 23 storage storage NN cord-010092-uftc8inx 8878 24 . . . cord-010092-uftc8inx 8879 1 One one CD cord-010092-uftc8inx 8879 2 sample sample NN cord-010092-uftc8inx 8879 3 with with IN cord-010092-uftc8inx 8879 4 anti anti JJ cord-010092-uftc8inx 8879 5 - - JJ cord-010092-uftc8inx 8879 6 Jk Jk NNP cord-010092-uftc8inx 8879 7 a a DT cord-010092-uftc8inx 8879 8 showed show VBN cord-010092-uftc8inx 8879 9 increased increase VBN cord-010092-uftc8inx 8879 10 reactivity reactivity NN cord-010092-uftc8inx 8879 11 only only RB cord-010092-uftc8inx 8879 12 after after IN cord-010092-uftc8inx 8879 13 1 1 CD cord-010092-uftc8inx 8879 14 month month NN cord-010092-uftc8inx 8879 15 storage storage NN cord-010092-uftc8inx 8879 16 , , , cord-010092-uftc8inx 8879 17 while while IN cord-010092-uftc8inx 8879 18 one one CD cord-010092-uftc8inx 8879 19 sample sample NN cord-010092-uftc8inx 8879 20 with with IN cord-010092-uftc8inx 8879 21 anti anti JJ cord-010092-uftc8inx 8879 22 - - NNP cord-010092-uftc8inx 8879 23 Xg Xg NNP cord-010092-uftc8inx 8879 24 a a DT cord-010092-uftc8inx 8879 25 showed show VBD cord-010092-uftc8inx 8879 26 decreased decrease VBN cord-010092-uftc8inx 8879 27 reactivity reactivity NN cord-010092-uftc8inx 8879 28 only only RB cord-010092-uftc8inx 8879 29 after after IN cord-010092-uftc8inx 8879 30 1 1 CD cord-010092-uftc8inx 8879 31 month month NN cord-010092-uftc8inx 8879 32 storage storage NN cord-010092-uftc8inx 8879 33 . . . cord-010092-uftc8inx 8880 1 Higher high JJR cord-010092-uftc8inx 8880 2 reactivities reactivity NNS cord-010092-uftc8inx 8880 3 were be VBD cord-010092-uftc8inx 8880 4 observed observe VBN cord-010092-uftc8inx 8880 5 in in IN cord-010092-uftc8inx 8880 6 all all DT cord-010092-uftc8inx 8880 7 samples sample NNS cord-010092-uftc8inx 8880 8 detected detect VBN cord-010092-uftc8inx 8880 9 using use VBG cord-010092-uftc8inx 8880 10 the the DT cord-010092-uftc8inx 8880 11 IH-500 IH-500 NNP cord-010092-uftc8inx 8880 12 analyzer analyzer NN cord-010092-uftc8inx 8880 13 than than IN cord-010092-uftc8inx 8880 14 manual manual JJ cord-010092-uftc8inx 8880 15 tube tube NN cord-010092-uftc8inx 8880 16 methods method NNS cord-010092-uftc8inx 8880 17 ( ( -LRB- cord-010092-uftc8inx 8880 18 P p NN cord-010092-uftc8inx 8880 19 < < XX cord-010092-uftc8inx 8880 20 0.005 0.005 XX cord-010092-uftc8inx 8880 21 , , , cord-010092-uftc8inx 8880 22 Wilcoxon Wilcoxon NNP cord-010092-uftc8inx 8880 23 rank rank VBP cord-010092-uftc8inx 8880 24 sum sum NN cord-010092-uftc8inx 8880 25 test test NN cord-010092-uftc8inx 8880 26 ) ) -RRB- cord-010092-uftc8inx 8880 27 . . . cord-010092-uftc8inx 8881 1 Summary Summary NNP cord-010092-uftc8inx 8881 2 / / SYM cord-010092-uftc8inx 8881 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 8881 4 : : : cord-010092-uftc8inx 8882 1 The the DT cord-010092-uftc8inx 8882 2 specificities specificity NNS cord-010092-uftc8inx 8882 3 of of IN cord-010092-uftc8inx 8882 4 unexpected unexpected JJ cord-010092-uftc8inx 8882 5 antibodies antibody NNS cord-010092-uftc8inx 8882 6 detected detect VBN cord-010092-uftc8inx 8882 7 by by IN cord-010092-uftc8inx 8882 8 IH-500 ih-500 NN cord-010092-uftc8inx 8882 9 and and CC cord-010092-uftc8inx 8882 10 tube tube NN cord-010092-uftc8inx 8882 11 methods method NNS cord-010092-uftc8inx 8882 12 were be VBD cord-010092-uftc8inx 8882 13 the the DT cord-010092-uftc8inx 8882 14 same same JJ cord-010092-uftc8inx 8882 15 in in IN cord-010092-uftc8inx 8882 16 all all DT cord-010092-uftc8inx 8882 17 storage storage NN cord-010092-uftc8inx 8882 18 states state NNS cord-010092-uftc8inx 8882 19 ; ; : cord-010092-uftc8inx 8882 20 however however RB cord-010092-uftc8inx 8882 21 , , , cord-010092-uftc8inx 8882 22 reactivities reactivity NNS cord-010092-uftc8inx 8882 23 were be VBD cord-010092-uftc8inx 8882 24 higher high JJR cord-010092-uftc8inx 8882 25 in in IN cord-010092-uftc8inx 8882 26 IH-500 IH-500 NNP cord-010092-uftc8inx 8882 27 than than IN cord-010092-uftc8inx 8882 28 in in IN cord-010092-uftc8inx 8882 29 the the DT cord-010092-uftc8inx 8882 30 tube tube NN cord-010092-uftc8inx 8882 31 method method NN cord-010092-uftc8inx 8882 32 . . . cord-010092-uftc8inx 8883 1 Twenty twenty CD cord-010092-uftc8inx 8883 2 - - HYPH cord-010092-uftc8inx 8883 3 six six CD cord-010092-uftc8inx 8883 4 ( ( -LRB- cord-010092-uftc8inx 8883 5 52 52 CD cord-010092-uftc8inx 8883 6 % % NN cord-010092-uftc8inx 8883 7 ) ) -RRB- cord-010092-uftc8inx 8883 8 of of IN cord-010092-uftc8inx 8883 9 50 50 CD cord-010092-uftc8inx 8883 10 samples sample NNS cord-010092-uftc8inx 8883 11 showed show VBD cord-010092-uftc8inx 8883 12 identical identical JJ cord-010092-uftc8inx 8883 13 reactivities reactivity NNS cord-010092-uftc8inx 8883 14 after after IN cord-010092-uftc8inx 8883 15 1 1 CD cord-010092-uftc8inx 8883 16 week week NN cord-010092-uftc8inx 8883 17 refrigeration refrigeration NN cord-010092-uftc8inx 8883 18 and and CC cord-010092-uftc8inx 8883 19 1 1 CD cord-010092-uftc8inx 8883 20 month month NN cord-010092-uftc8inx 8883 21 freezing freezing NN cord-010092-uftc8inx 8883 22 . . . cord-010092-uftc8inx 8884 1 Nineteen nineteen CD cord-010092-uftc8inx 8884 2 ( ( -LRB- cord-010092-uftc8inx 8884 3 38 38 CD cord-010092-uftc8inx 8884 4 % % NN cord-010092-uftc8inx 8884 5 ) ) -RRB- cord-010092-uftc8inx 8884 6 samples sample NNS cord-010092-uftc8inx 8884 7 showed show VBD cord-010092-uftc8inx 8884 8 decreased decrease VBN cord-010092-uftc8inx 8884 9 reactivities reactivity NNS cord-010092-uftc8inx 8884 10 after after IN cord-010092-uftc8inx 8884 11 storage storage NN cord-010092-uftc8inx 8884 12 ; ; : cord-010092-uftc8inx 8884 13 however however RB cord-010092-uftc8inx 8884 14 , , , cord-010092-uftc8inx 8884 15 12 12 CD cord-010092-uftc8inx 8884 16 ( ( -LRB- cord-010092-uftc8inx 8884 17 12/19 12/19 CD cord-010092-uftc8inx 8884 18 , , , cord-010092-uftc8inx 8884 19 63 63 CD cord-010092-uftc8inx 8884 20 % % NN cord-010092-uftc8inx 8884 21 ) ) -RRB- cord-010092-uftc8inx 8884 22 of of IN cord-010092-uftc8inx 8884 23 them -PRON- PRP cord-010092-uftc8inx 8884 24 were be VBD cord-010092-uftc8inx 8884 25 nonspecific nonspecific JJ cord-010092-uftc8inx 8884 26 antibodies antibody NNS cord-010092-uftc8inx 8884 27 , , , cord-010092-uftc8inx 8884 28 unable unable JJ cord-010092-uftc8inx 8884 29 to to TO cord-010092-uftc8inx 8884 30 identify identify VB cord-010092-uftc8inx 8884 31 using use VBG cord-010092-uftc8inx 8884 32 commercial commercial JJ cord-010092-uftc8inx 8884 33 ID ID NNP cord-010092-uftc8inx 8884 34 panels panel NNS cord-010092-uftc8inx 8884 35 . . . cord-010092-uftc8inx 8885 1 Therefore therefore RB cord-010092-uftc8inx 8885 2 , , , cord-010092-uftc8inx 8885 3 it -PRON- PRP cord-010092-uftc8inx 8885 4 is be VBZ cord-010092-uftc8inx 8885 5 suggested suggest VBN cord-010092-uftc8inx 8885 6 that that IN cord-010092-uftc8inx 8885 7 retests retest NNS cord-010092-uftc8inx 8885 8 for for IN cord-010092-uftc8inx 8885 9 evaluation evaluation NN cord-010092-uftc8inx 8885 10 of of IN cord-010092-uftc8inx 8885 11 transfusion transfusion NN cord-010092-uftc8inx 8885 12 reaction reaction NN cord-010092-uftc8inx 8885 13 , , , cord-010092-uftc8inx 8885 14 quality quality NN cord-010092-uftc8inx 8885 15 control control NN cord-010092-uftc8inx 8885 16 or or CC cord-010092-uftc8inx 8885 17 research research NN cord-010092-uftc8inx 8885 18 could could MD cord-010092-uftc8inx 8885 19 be be VB cord-010092-uftc8inx 8885 20 reliably reliably RB cord-010092-uftc8inx 8885 21 performed perform VBN cord-010092-uftc8inx 8885 22 after after IN cord-010092-uftc8inx 8885 23 more more JJR cord-010092-uftc8inx 8885 24 than than IN cord-010092-uftc8inx 8885 25 3 3 CD cord-010092-uftc8inx 8885 26 days day NNS cord-010092-uftc8inx 8885 27 , , , cord-010092-uftc8inx 8885 28 if if IN cord-010092-uftc8inx 8885 29 stored store VBN cord-010092-uftc8inx 8885 30 appropriately appropriately RB cord-010092-uftc8inx 8885 31 in in IN cord-010092-uftc8inx 8885 32 refrigerated refrigerated JJ cord-010092-uftc8inx 8885 33 or or CC cord-010092-uftc8inx 8885 34 frozen frozen JJ cord-010092-uftc8inx 8885 35 states state NNS cord-010092-uftc8inx 8885 36 . . . cord-010092-uftc8inx 8886 1 Abstract Abstract NNP cord-010092-uftc8inx 8886 2 withdrawn withdraw VBN cord-010092-uftc8inx 8886 3 . . . cord-010092-uftc8inx 8887 1 T T NNP cord-010092-uftc8inx 8887 2 Gleich Gleich NNP cord-010092-uftc8inx 8887 3 - - HYPH cord-010092-uftc8inx 8887 4 Nagel Nagel NNP cord-010092-uftc8inx 8887 5 1 1 CD cord-010092-uftc8inx 8887 6 , , , cord-010092-uftc8inx 8887 7 D D NNP cord-010092-uftc8inx 8887 8 Huber Huber NNP cord-010092-uftc8inx 8887 9 - - HYPH cord-010092-uftc8inx 8887 10 Marcantonio Marcantonio NNP cord-010092-uftc8inx 8887 11 1 1 CD cord-010092-uftc8inx 8887 12 , , , cord-010092-uftc8inx 8887 13 N N NNP cord-010092-uftc8inx 8887 14 Rufer Rufer NNP cord-010092-uftc8inx 8887 15 1 1 CD cord-010092-uftc8inx 8887 16 , , , cord-010092-uftc8inx 8887 17 G G NNP cord-010092-uftc8inx 8887 18 Canellini Canellini NNP cord-010092-uftc8inx 8887 19 1 1 CD cord-010092-uftc8inx 8887 20 and and CC cord-010092-uftc8inx 8887 21 C C NNP cord-010092-uftc8inx 8887 22 Niederhauser Niederhauser NNP cord-010092-uftc8inx 8887 23 2 2 CD cord-010092-uftc8inx 8887 24 1 1 CD cord-010092-uftc8inx 8887 25 Unit Unit NNP cord-010092-uftc8inx 8887 26 of of IN cord-010092-uftc8inx 8887 27 transfusion transfusion NN cord-010092-uftc8inx 8887 28 medicine medicine NN cord-010092-uftc8inx 8887 29 , , , cord-010092-uftc8inx 8887 30 Interregional Interregional NNP cord-010092-uftc8inx 8887 31 Blood Blood NNP cord-010092-uftc8inx 8887 32 Transfusion Transfusion NNP cord-010092-uftc8inx 8887 33 SRC SRC NNP cord-010092-uftc8inx 8887 34 , , , cord-010092-uftc8inx 8887 35 Lausanne Lausanne NNP cord-010092-uftc8inx 8887 36 2 2 CD cord-010092-uftc8inx 8887 37 Laboratory Laboratory NNP cord-010092-uftc8inx 8887 38 Diagnostics Diagnostics NNPS cord-010092-uftc8inx 8887 39 , , , cord-010092-uftc8inx 8887 40 Interregional Interregional NNP cord-010092-uftc8inx 8887 41 Blood Blood NNP cord-010092-uftc8inx 8887 42 Transfusion Transfusion NNP cord-010092-uftc8inx 8887 43 SRC SRC NNP cord-010092-uftc8inx 8887 44 , , , cord-010092-uftc8inx 8887 45 Bern Bern NNP cord-010092-uftc8inx 8887 46 , , , cord-010092-uftc8inx 8887 47 Switzerland Switzerland NNP cord-010092-uftc8inx 8887 48 Background Background NNP cord-010092-uftc8inx 8887 49 : : : cord-010092-uftc8inx 8888 1 A a DT cord-010092-uftc8inx 8888 2 positive positive JJ cord-010092-uftc8inx 8888 3 direct direct JJ cord-010092-uftc8inx 8888 4 antiglobulin antiglobulin NN cord-010092-uftc8inx 8888 5 test test NN cord-010092-uftc8inx 8888 6 ( ( -LRB- cord-010092-uftc8inx 8888 7 DAT DAT NNP cord-010092-uftc8inx 8888 8 ) ) -RRB- cord-010092-uftc8inx 8888 9 is be VBZ cord-010092-uftc8inx 8888 10 mainly mainly RB cord-010092-uftc8inx 8888 11 found find VBN cord-010092-uftc8inx 8888 12 in in IN cord-010092-uftc8inx 8888 13 patients patient NNS cord-010092-uftc8inx 8888 14 with with IN cord-010092-uftc8inx 8888 15 warm warm JJ cord-010092-uftc8inx 8888 16 / / SYM cord-010092-uftc8inx 8888 17 cold cold JJ cord-010092-uftc8inx 8888 18 autoantibodies autoantibody NNS cord-010092-uftc8inx 8888 19 or or CC cord-010092-uftc8inx 8888 20 alloantibodies alloantibody NNS cord-010092-uftc8inx 8888 21 directed direct VBN cord-010092-uftc8inx 8888 22 against against IN cord-010092-uftc8inx 8888 23 transfused transfused JJ cord-010092-uftc8inx 8888 24 erythrocytes erythrocyte NNS cord-010092-uftc8inx 8888 25 . . . cord-010092-uftc8inx 8889 1 The the DT cord-010092-uftc8inx 8889 2 identification identification NN cord-010092-uftc8inx 8889 3 of of IN cord-010092-uftc8inx 8889 4 antibodies antibody NNS cord-010092-uftc8inx 8889 5 fixed fix VBN cord-010092-uftc8inx 8889 6 on on IN cord-010092-uftc8inx 8889 7 red red JJ cord-010092-uftc8inx 8889 8 cells cell NNS cord-010092-uftc8inx 8889 9 is be VBZ cord-010092-uftc8inx 8889 10 important important JJ cord-010092-uftc8inx 8889 11 for for IN cord-010092-uftc8inx 8889 12 the the DT cord-010092-uftc8inx 8889 13 clinician clinician NN cord-010092-uftc8inx 8889 14 , , , cord-010092-uftc8inx 8889 15 allowing allow VBG cord-010092-uftc8inx 8889 16 the the DT cord-010092-uftc8inx 8889 17 further further JJ cord-010092-uftc8inx 8889 18 evaluation evaluation NN cord-010092-uftc8inx 8889 19 of of IN cord-010092-uftc8inx 8889 20 a a DT cord-010092-uftc8inx 8889 21 patient patient NN cord-010092-uftc8inx 8889 22 's 's POS cord-010092-uftc8inx 8889 23 clinical clinical JJ cord-010092-uftc8inx 8889 24 situation situation NN cord-010092-uftc8inx 8889 25 including include VBG cord-010092-uftc8inx 8889 26 their -PRON- PRP$ cord-010092-uftc8inx 8889 27 current current JJ cord-010092-uftc8inx 8889 28 medication medication NN cord-010092-uftc8inx 8889 29 . . . cord-010092-uftc8inx 8890 1 In in IN cord-010092-uftc8inx 8890 2 immunohematology immunohematology NN cord-010092-uftc8inx 8890 3 the the DT cord-010092-uftc8inx 8890 4 elution elution NN cord-010092-uftc8inx 8890 5 of of IN cord-010092-uftc8inx 8890 6 a a DT cord-010092-uftc8inx 8890 7 positive positive JJ cord-010092-uftc8inx 8890 8 DAT DAT NNP cord-010092-uftc8inx 8890 9 remains remain VBZ cord-010092-uftc8inx 8890 10 a a DT cord-010092-uftc8inx 8890 11 tedious tedious JJ cord-010092-uftc8inx 8890 12 and and CC cord-010092-uftc8inx 8890 13 expensive expensive JJ cord-010092-uftc8inx 8890 14 procedure procedure NN cord-010092-uftc8inx 8890 15 . . . cord-010092-uftc8inx 8891 1 The the DT cord-010092-uftc8inx 8891 2 Blood Blood NNP cord-010092-uftc8inx 8891 3 Transfusion Transfusion NNP cord-010092-uftc8inx 8891 4 Service Service NNP cord-010092-uftc8inx 8891 5 SRC SRC NNP cord-010092-uftc8inx 8891 6 ( ( -LRB- cord-010092-uftc8inx 8891 7 BTS BTS NNP cord-010092-uftc8inx 8891 8 SRC SRC NNP cord-010092-uftc8inx 8891 9 ) ) -RRB- cord-010092-uftc8inx 8891 10 has have VBZ cord-010092-uftc8inx 8891 11 derived derive VBN cord-010092-uftc8inx 8891 12 a a DT cord-010092-uftc8inx 8891 13 flow flow NN cord-010092-uftc8inx 8891 14 chart chart NN cord-010092-uftc8inx 8891 15 that that WDT cord-010092-uftc8inx 8891 16 indicates indicate VBZ cord-010092-uftc8inx 8891 17 in in IN cord-010092-uftc8inx 8891 18 which which WDT cord-010092-uftc8inx 8891 19 situation situation NN cord-010092-uftc8inx 8891 20 an an DT cord-010092-uftc8inx 8891 21 elution elution NN cord-010092-uftc8inx 8891 22 of of IN cord-010092-uftc8inx 8891 23 DAT DAT NNP cord-010092-uftc8inx 8891 24 positive positive JJ cord-010092-uftc8inx 8891 25 samples sample NNS cord-010092-uftc8inx 8891 26 should should MD cord-010092-uftc8inx 8891 27 be be VB cord-010092-uftc8inx 8891 28 performed perform VBN cord-010092-uftc8inx 8891 29 . . . cord-010092-uftc8inx 8892 1 In in IN cord-010092-uftc8inx 8892 2 order order NN cord-010092-uftc8inx 8892 3 to to TO cord-010092-uftc8inx 8892 4 follow follow VB cord-010092-uftc8inx 8892 5 the the DT cord-010092-uftc8inx 8892 6 BTS BTS NNP cord-010092-uftc8inx 8892 7 SRC SRC NNP cord-010092-uftc8inx 8892 8 guidelines guideline NNS cord-010092-uftc8inx 8892 9 , , , cord-010092-uftc8inx 8892 10 it -PRON- PRP cord-010092-uftc8inx 8892 11 is be VBZ cord-010092-uftc8inx 8892 12 mandatory mandatory JJ cord-010092-uftc8inx 8892 13 to to TO cord-010092-uftc8inx 8892 14 obtain obtain VB cord-010092-uftc8inx 8892 15 additional additional JJ cord-010092-uftc8inx 8892 16 data datum NNS cord-010092-uftc8inx 8892 17 related relate VBN cord-010092-uftc8inx 8892 18 to to IN cord-010092-uftc8inx 8892 19 the the DT cord-010092-uftc8inx 8892 20 patient patient NN cord-010092-uftc8inx 8892 21 's 's POS cord-010092-uftc8inx 8892 22 condition condition NN cord-010092-uftc8inx 8892 23 , , , cord-010092-uftc8inx 8892 24 such such JJ cord-010092-uftc8inx 8892 25 as as IN cord-010092-uftc8inx 8892 26 haemolytic haemolytic JJ cord-010092-uftc8inx 8892 27 parameters parameter NNS cord-010092-uftc8inx 8892 28 and and CC cord-010092-uftc8inx 8892 29 recent recent JJ cord-010092-uftc8inx 8892 30 transfusion transfusion NN cord-010092-uftc8inx 8892 31 history history NN cord-010092-uftc8inx 8892 32 . . . cord-010092-uftc8inx 8893 1 Currently currently RB cord-010092-uftc8inx 8893 2 , , , cord-010092-uftc8inx 8893 3 our -PRON- PRP$ cord-010092-uftc8inx 8893 4 laboratory laboratory NN cord-010092-uftc8inx 8893 5 is be VBZ cord-010092-uftc8inx 8893 6 not not RB cord-010092-uftc8inx 8893 7 always always RB cord-010092-uftc8inx 8893 8 able able JJ cord-010092-uftc8inx 8893 9 to to TO cord-010092-uftc8inx 8893 10 apply apply VB cord-010092-uftc8inx 8893 11 the the DT cord-010092-uftc8inx 8893 12 recommended recommend VBN cord-010092-uftc8inx 8893 13 flowchart flowchart NN cord-010092-uftc8inx 8893 14 , , , cord-010092-uftc8inx 8893 15 since since IN cord-010092-uftc8inx 8893 16 information information NN cord-010092-uftc8inx 8893 17 is be VBZ cord-010092-uftc8inx 8893 18 often often RB cord-010092-uftc8inx 8893 19 unavailable unavailable JJ cord-010092-uftc8inx 8893 20 . . . cord-010092-uftc8inx 8894 1 Aims aim VBZ cord-010092-uftc8inx 8894 2 : : : cord-010092-uftc8inx 8895 1 Here here RB cord-010092-uftc8inx 8895 2 , , , cord-010092-uftc8inx 8895 3 we -PRON- PRP cord-010092-uftc8inx 8895 4 performed perform VBD cord-010092-uftc8inx 8895 5 a a DT cord-010092-uftc8inx 8895 6 comparative comparative JJ cord-010092-uftc8inx 8895 7 study study NN cord-010092-uftc8inx 8895 8 between between IN cord-010092-uftc8inx 8895 9 the the DT cord-010092-uftc8inx 8895 10 algorithm algorithm NN cord-010092-uftc8inx 8895 11 provided provide VBN cord-010092-uftc8inx 8895 12 by by IN cord-010092-uftc8inx 8895 13 BTS BTS NNP cord-010092-uftc8inx 8895 14 SRC SRC NNP cord-010092-uftc8inx 8895 15 and and CC cord-010092-uftc8inx 8895 16 our -PRON- PRP$ cord-010092-uftc8inx 8895 17 in in IN cord-010092-uftc8inx 8895 18 - - HYPH cord-010092-uftc8inx 8895 19 house house NN cord-010092-uftc8inx 8895 20 strategy strategy NN cord-010092-uftc8inx 8895 21 , , , cord-010092-uftc8inx 8895 22 which which WDT cord-010092-uftc8inx 8895 23 is be VBZ cord-010092-uftc8inx 8895 24 based base VBN cord-010092-uftc8inx 8895 25 on on IN cord-010092-uftc8inx 8895 26 the the DT cord-010092-uftc8inx 8895 27 qualitative qualitative JJ cord-010092-uftc8inx 8895 28 changes change NNS cord-010092-uftc8inx 8895 29 of of IN cord-010092-uftc8inx 8895 30 a a DT cord-010092-uftc8inx 8895 31 positive positive JJ cord-010092-uftc8inx 8895 32 DAT dat NN cord-010092-uftc8inx 8895 33 , , , cord-010092-uftc8inx 8895 34 without without IN cord-010092-uftc8inx 8895 35 the the DT cord-010092-uftc8inx 8895 36 need need NN cord-010092-uftc8inx 8895 37 for for IN cord-010092-uftc8inx 8895 38 additional additional JJ cord-010092-uftc8inx 8895 39 patient patient JJ cord-010092-uftc8inx 8895 40 and and CC cord-010092-uftc8inx 8895 41 biological biological JJ cord-010092-uftc8inx 8895 42 information information NN cord-010092-uftc8inx 8895 43 . . . cord-010092-uftc8inx 8896 1 Methods method NNS cord-010092-uftc8inx 8896 2 : : : cord-010092-uftc8inx 8896 3 Details detail NNS cord-010092-uftc8inx 8896 4 of of IN cord-010092-uftc8inx 8896 5 DAT DAT NNP cord-010092-uftc8inx 8896 6 positivity positivity NN cord-010092-uftc8inx 8896 7 and and CC cord-010092-uftc8inx 8896 8 the the DT cord-010092-uftc8inx 8896 9 patient patient NN cord-010092-uftc8inx 8896 10 's 's POS cord-010092-uftc8inx 8896 11 transfusion transfusion NN cord-010092-uftc8inx 8896 12 history history NN cord-010092-uftc8inx 8896 13 was be VBD cord-010092-uftc8inx 8896 14 taken take VBN cord-010092-uftc8inx 8896 15 from from IN cord-010092-uftc8inx 8896 16 the the DT cord-010092-uftc8inx 8896 17 software software NN cord-010092-uftc8inx 8896 18 eProgesa eProgesa NNP cord-010092-uftc8inx 8896 19 ( ( -LRB- cord-010092-uftc8inx 8896 20 MAK MAK NNP cord-010092-uftc8inx 8896 21 - - HYPH cord-010092-uftc8inx 8896 22 system system NN cord-010092-uftc8inx 8896 23 ) ) -RRB- cord-010092-uftc8inx 8896 24 and and CC cord-010092-uftc8inx 8896 25 analysed analyse VBN cord-010092-uftc8inx 8896 26 in in IN cord-010092-uftc8inx 8896 27 Excel Excel NNP cord-010092-uftc8inx 8896 28 . . . cord-010092-uftc8inx 8897 1 We -PRON- PRP cord-010092-uftc8inx 8897 2 analysed analyse VBD cord-010092-uftc8inx 8897 3 a a DT cord-010092-uftc8inx 8897 4 total total NN cord-010092-uftc8inx 8897 5 of of IN cord-010092-uftc8inx 8897 6 3'753 3'753 CD cord-010092-uftc8inx 8897 7 DATs DATs NNPS cord-010092-uftc8inx 8897 8 and and CC cord-010092-uftc8inx 8897 9 evaluated evaluate VBD cord-010092-uftc8inx 8897 10 them -PRON- PRP cord-010092-uftc8inx 8897 11 for for IN cord-010092-uftc8inx 8897 12 their -PRON- PRP$ cord-010092-uftc8inx 8897 13 positivity positivity NN cord-010092-uftc8inx 8897 14 , , , cord-010092-uftc8inx 8897 15 whether whether IN cord-010092-uftc8inx 8897 16 an an DT cord-010092-uftc8inx 8897 17 elution elution NN cord-010092-uftc8inx 8897 18 was be VBD cord-010092-uftc8inx 8897 19 performed perform VBN cord-010092-uftc8inx 8897 20 or or CC cord-010092-uftc8inx 8897 21 whether whether IN cord-010092-uftc8inx 8897 22 antibodies antibody NNS cord-010092-uftc8inx 8897 23 were be VBD cord-010092-uftc8inx 8897 24 detectable detectable JJ cord-010092-uftc8inx 8897 25 in in IN cord-010092-uftc8inx 8897 26 the the DT cord-010092-uftc8inx 8897 27 eluate eluate NN cord-010092-uftc8inx 8897 28 . . . cord-010092-uftc8inx 8898 1 Furthermore furthermore RB cord-010092-uftc8inx 8898 2 , , , cord-010092-uftc8inx 8898 3 we -PRON- PRP cord-010092-uftc8inx 8898 4 performed perform VBD cord-010092-uftc8inx 8898 5 an an DT cord-010092-uftc8inx 8898 6 additional additional JJ cord-010092-uftc8inx 8898 7 analysis analysis NN cord-010092-uftc8inx 8898 8 on on IN cord-010092-uftc8inx 8898 9 those those DT cord-010092-uftc8inx 8898 10 samples sample NNS cord-010092-uftc8inx 8898 11 , , , cord-010092-uftc8inx 8898 12 that that WDT cord-010092-uftc8inx 8898 13 were be VBD cord-010092-uftc8inx 8898 14 derived derive VBN cord-010092-uftc8inx 8898 15 from from IN cord-010092-uftc8inx 8898 16 recently recently RB cord-010092-uftc8inx 8898 17 transfused transfuse VBN cord-010092-uftc8inx 8898 18 patients patient NNS cord-010092-uftc8inx 8898 19 ( ( -LRB- cord-010092-uftc8inx 8898 20 < < NNP cord-010092-uftc8inx 8898 21 14 14 CD cord-010092-uftc8inx 8898 22 days day NNS cord-010092-uftc8inx 8898 23 ) ) -RRB- cord-010092-uftc8inx 8898 24 . . . cord-010092-uftc8inx 8899 1 Results result NNS cord-010092-uftc8inx 8899 2 : : : cord-010092-uftc8inx 8900 1 A a DT cord-010092-uftc8inx 8900 2 positive positive JJ cord-010092-uftc8inx 8900 3 DAT dat NN cord-010092-uftc8inx 8900 4 was be VBD cord-010092-uftc8inx 8900 5 found find VBN cord-010092-uftc8inx 8900 6 for for IN cord-010092-uftc8inx 8900 7 IgG IgG NNP cord-010092-uftc8inx 8900 8 and and CC cord-010092-uftc8inx 8900 9 C3d C3d NNP cord-010092-uftc8inx 8900 10 in in IN cord-010092-uftc8inx 8900 11 421 421 CD cord-010092-uftc8inx 8900 12 out out IN cord-010092-uftc8inx 8900 13 of of IN cord-010092-uftc8inx 8900 14 3'753 3'753 CD cord-010092-uftc8inx 8900 15 ( ( -LRB- cord-010092-uftc8inx 8900 16 11.2 11.2 CD cord-010092-uftc8inx 8900 17 % % NN cord-010092-uftc8inx 8900 18 ) ) -RRB- cord-010092-uftc8inx 8900 19 samples sample NNS cord-010092-uftc8inx 8900 20 , , , cord-010092-uftc8inx 8900 21 a a DT cord-010092-uftc8inx 8900 22 level level NN cord-010092-uftc8inx 8900 23 similar similar JJ cord-010092-uftc8inx 8900 24 to to IN cord-010092-uftc8inx 8900 25 previous previous JJ cord-010092-uftc8inx 8900 26 reports report NNS cord-010092-uftc8inx 8900 27 of of IN cord-010092-uftc8inx 8900 28 positive positive JJ cord-010092-uftc8inx 8900 29 DATs dat NNS cord-010092-uftc8inx 8900 30 for for IN cord-010092-uftc8inx 8900 31 hospitalized hospitalize VBN cord-010092-uftc8inx 8900 32 patients patient NNS cord-010092-uftc8inx 8900 33 . . . cord-010092-uftc8inx 8901 1 Among among IN cord-010092-uftc8inx 8901 2 these these DT cord-010092-uftc8inx 8901 3 positive positive JJ cord-010092-uftc8inx 8901 4 samples sample NNS cord-010092-uftc8inx 8901 5 , , , cord-010092-uftc8inx 8901 6 244 244 CD cord-010092-uftc8inx 8901 7 ( ( -LRB- cord-010092-uftc8inx 8901 8 57 57 CD cord-010092-uftc8inx 8901 9 % % NN cord-010092-uftc8inx 8901 10 ) ) -RRB- cord-010092-uftc8inx 8901 11 were be VBD cord-010092-uftc8inx 8901 12 eluted elute VBN cord-010092-uftc8inx 8901 13 because because IN cord-010092-uftc8inx 8901 14 of of IN cord-010092-uftc8inx 8901 15 a a DT cord-010092-uftc8inx 8901 16 qualitative qualitative JJ cord-010092-uftc8inx 8901 17 change change NN cord-010092-uftc8inx 8901 18 in in IN cord-010092-uftc8inx 8901 19 their -PRON- PRP$ cord-010092-uftc8inx 8901 20 positivity positivity NN cord-010092-uftc8inx 8901 21 according accord VBG cord-010092-uftc8inx 8901 22 to to IN cord-010092-uftc8inx 8901 23 our -PRON- PRP$ cord-010092-uftc8inx 8901 24 in in IN cord-010092-uftc8inx 8901 25 - - HYPH cord-010092-uftc8inx 8901 26 house house NN cord-010092-uftc8inx 8901 27 algorithm algorithm NN cord-010092-uftc8inx 8901 28 . . . cord-010092-uftc8inx 8902 1 Identification identification NN cord-010092-uftc8inx 8902 2 of of IN cord-010092-uftc8inx 8902 3 warm warm JJ cord-010092-uftc8inx 8902 4 autoantibodies autoantibody NNS cord-010092-uftc8inx 8902 5 or or CC cord-010092-uftc8inx 8902 6 alloantibodies alloantibody NNS cord-010092-uftc8inx 8902 7 occurred occur VBD cord-010092-uftc8inx 8902 8 in in IN cord-010092-uftc8inx 8902 9 only only RB cord-010092-uftc8inx 8902 10 10.7 10.7 CD cord-010092-uftc8inx 8902 11 % % NN cord-010092-uftc8inx 8902 12 ( ( -LRB- cord-010092-uftc8inx 8902 13 26/244 26/244 CD cord-010092-uftc8inx 8902 14 ) ) -RRB- cord-010092-uftc8inx 8902 15 of of IN cord-010092-uftc8inx 8902 16 the the DT cord-010092-uftc8inx 8902 17 cases case NNS cord-010092-uftc8inx 8902 18 . . . cord-010092-uftc8inx 8903 1 From from IN cord-010092-uftc8inx 8903 2 the the DT cord-010092-uftc8inx 8903 3 161 161 CD cord-010092-uftc8inx 8903 4 patients patient NNS cord-010092-uftc8inx 8903 5 transfused transfuse VBN cord-010092-uftc8inx 8903 6 within within IN cord-010092-uftc8inx 8903 7 the the DT cord-010092-uftc8inx 8903 8 last last JJ cord-010092-uftc8inx 8903 9 14 14 CD cord-010092-uftc8inx 8903 10 days day NNS cord-010092-uftc8inx 8903 11 and and CC cord-010092-uftc8inx 8903 12 having have VBG cord-010092-uftc8inx 8903 13 a a DT cord-010092-uftc8inx 8903 14 positive positive JJ cord-010092-uftc8inx 8903 15 DAT DAT NNP cord-010092-uftc8inx 8903 16 , , , cord-010092-uftc8inx 8903 17 60 60 CD cord-010092-uftc8inx 8903 18 ( ( -LRB- cord-010092-uftc8inx 8903 19 14 14 CD cord-010092-uftc8inx 8903 20 % % NN cord-010092-uftc8inx 8903 21 ) ) -RRB- cord-010092-uftc8inx 8903 22 were be VBD cord-010092-uftc8inx 8903 23 eluted elute VBN cord-010092-uftc8inx 8903 24 according accord VBG cord-010092-uftc8inx 8903 25 to to IN cord-010092-uftc8inx 8903 26 our -PRON- PRP$ cord-010092-uftc8inx 8903 27 in in IN cord-010092-uftc8inx 8903 28 - - HYPH cord-010092-uftc8inx 8903 29 house house NN cord-010092-uftc8inx 8903 30 algorithm algorithm NN cord-010092-uftc8inx 8903 31 . . . cord-010092-uftc8inx 8904 1 The the DT cord-010092-uftc8inx 8904 2 same same JJ cord-010092-uftc8inx 8904 3 samples sample NNS cord-010092-uftc8inx 8904 4 would would MD cord-010092-uftc8inx 8904 5 have have VB cord-010092-uftc8inx 8904 6 been be VBN cord-010092-uftc8inx 8904 7 analysed analyse VBN cord-010092-uftc8inx 8904 8 if if IN cord-010092-uftc8inx 8904 9 the the DT cord-010092-uftc8inx 8904 10 Swiss Swiss NNP cord-010092-uftc8inx 8904 11 Transfusion Transfusion NNP cord-010092-uftc8inx 8904 12 guidelines guideline NNS cord-010092-uftc8inx 8904 13 had have VBD cord-010092-uftc8inx 8904 14 been be VBN cord-010092-uftc8inx 8904 15 applied apply VBN cord-010092-uftc8inx 8904 16 . . . cord-010092-uftc8inx 8905 1 However however RB cord-010092-uftc8inx 8905 2 , , , cord-010092-uftc8inx 8905 3 this this DT cord-010092-uftc8inx 8905 4 comparative comparative JJ cord-010092-uftc8inx 8905 5 study study NN cord-010092-uftc8inx 8905 6 reveals reveal VBZ cord-010092-uftc8inx 8905 7 a a DT cord-010092-uftc8inx 8905 8 significant significant JJ cord-010092-uftc8inx 8905 9 discrepancy discrepancy NN cord-010092-uftc8inx 8905 10 in in IN cord-010092-uftc8inx 8905 11 regards regard NNS cord-010092-uftc8inx 8905 12 to to IN cord-010092-uftc8inx 8905 13 overall overall JJ cord-010092-uftc8inx 8905 14 sample sample NN cord-010092-uftc8inx 8905 15 numbers number NNS cord-010092-uftc8inx 8905 16 that that WDT cord-010092-uftc8inx 8905 17 should should MD cord-010092-uftc8inx 8905 18 have have VB cord-010092-uftc8inx 8905 19 been be VBN cord-010092-uftc8inx 8905 20 eluted elute VBN cord-010092-uftc8inx 8905 21 according accord VBG cord-010092-uftc8inx 8905 22 to to IN cord-010092-uftc8inx 8905 23 the the DT cord-010092-uftc8inx 8905 24 two two CD cord-010092-uftc8inx 8905 25 algorithms algorithm NNS cord-010092-uftc8inx 8905 26 ( ( -LRB- cord-010092-uftc8inx 8905 27 244 244 CD cord-010092-uftc8inx 8905 28 versus versus IN cord-010092-uftc8inx 8905 29 60 60 CD cord-010092-uftc8inx 8905 30 samples sample NNS cord-010092-uftc8inx 8905 31 ) ) -RRB- cord-010092-uftc8inx 8905 32 . . . cord-010092-uftc8inx 8906 1 This this DT cord-010092-uftc8inx 8906 2 is be VBZ cord-010092-uftc8inx 8906 3 mainly mainly RB cord-010092-uftc8inx 8906 4 due due JJ cord-010092-uftc8inx 8906 5 to to IN cord-010092-uftc8inx 8906 6 the the DT cord-010092-uftc8inx 8906 7 fact fact NN cord-010092-uftc8inx 8906 8 that that IN cord-010092-uftc8inx 8906 9 the the DT cord-010092-uftc8inx 8906 10 Swiss Swiss NNP cord-010092-uftc8inx 8906 11 Transfusion Transfusion NNP cord-010092-uftc8inx 8906 12 based base VBN cord-010092-uftc8inx 8906 13 algorithm algorithm NN cord-010092-uftc8inx 8906 14 does do VBZ cord-010092-uftc8inx 8906 15 not not RB cord-010092-uftc8inx 8906 16 recommend recommend VB cord-010092-uftc8inx 8906 17 an an DT cord-010092-uftc8inx 8906 18 elution elution NN cord-010092-uftc8inx 8906 19 of of IN cord-010092-uftc8inx 8906 20 positive positive JJ cord-010092-uftc8inx 8906 21 DATs dat NNS cord-010092-uftc8inx 8906 22 from from IN cord-010092-uftc8inx 8906 23 patients patient NNS cord-010092-uftc8inx 8906 24 who who WP cord-010092-uftc8inx 8906 25 did do VBD cord-010092-uftc8inx 8906 26 not not RB cord-010092-uftc8inx 8906 27 receive receive VB cord-010092-uftc8inx 8906 28 a a DT cord-010092-uftc8inx 8906 29 transfusion transfusion NN cord-010092-uftc8inx 8906 30 within within IN cord-010092-uftc8inx 8906 31 the the DT cord-010092-uftc8inx 8906 32 last last JJ cord-010092-uftc8inx 8906 33 14-days 14-days CD cord-010092-uftc8inx 8906 34 , , , cord-010092-uftc8inx 8906 35 except except IN cord-010092-uftc8inx 8906 36 if if IN cord-010092-uftc8inx 8906 37 there there EX cord-010092-uftc8inx 8906 38 is be VBZ cord-010092-uftc8inx 8906 39 a a DT cord-010092-uftc8inx 8906 40 significant significant JJ cord-010092-uftc8inx 8906 41 clinical clinical JJ cord-010092-uftc8inx 8906 42 suspicion suspicion NN cord-010092-uftc8inx 8906 43 ( ( -LRB- cord-010092-uftc8inx 8906 44 e.g. e.g. NNP cord-010092-uftc8inx 8906 45 haemolysis haemolysis NNP cord-010092-uftc8inx 8906 46 ) ) -RRB- cord-010092-uftc8inx 8906 47 . . . cord-010092-uftc8inx 8907 1 Summary Summary NNP cord-010092-uftc8inx 8907 2 / / SYM cord-010092-uftc8inx 8907 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 8907 4 : : : cord-010092-uftc8inx 8908 1 This this DT cord-010092-uftc8inx 8908 2 comparative comparative JJ cord-010092-uftc8inx 8908 3 study study NN cord-010092-uftc8inx 8908 4 indicates indicate VBZ cord-010092-uftc8inx 8908 5 that that IN cord-010092-uftc8inx 8908 6 our -PRON- PRP$ cord-010092-uftc8inx 8908 7 elution elution NN cord-010092-uftc8inx 8908 8 - - HYPH cord-010092-uftc8inx 8908 9 based base VBN cord-010092-uftc8inx 8908 10 algorithm algorithm NN cord-010092-uftc8inx 8908 11 was be VBD cord-010092-uftc8inx 8908 12 performed perform VBN cord-010092-uftc8inx 8908 13 on on IN cord-010092-uftc8inx 8908 14 all all DT cord-010092-uftc8inx 8908 15 clinically clinically RB cord-010092-uftc8inx 8908 16 relevant relevant JJ cord-010092-uftc8inx 8908 17 samples sample NNS cord-010092-uftc8inx 8908 18 as as IN cord-010092-uftc8inx 8908 19 recommended recommend VBN cord-010092-uftc8inx 8908 20 by by IN cord-010092-uftc8inx 8908 21 the the DT cord-010092-uftc8inx 8908 22 BTS BTS NNP cord-010092-uftc8inx 8908 23 SRC SRC NNP cord-010092-uftc8inx 8908 24 guidelines guideline NNS cord-010092-uftc8inx 8908 25 . . . cord-010092-uftc8inx 8909 1 Qualitative qualitative JJ cord-010092-uftc8inx 8909 2 changes change NNS cord-010092-uftc8inx 8909 3 in in IN cord-010092-uftc8inx 8909 4 the the DT cord-010092-uftc8inx 8909 5 DAT DAT NNP cord-010092-uftc8inx 8909 6 positivity positivity NN cord-010092-uftc8inx 8909 7 represent represent VBP cord-010092-uftc8inx 8909 8 our -PRON- PRP$ cord-010092-uftc8inx 8909 9 main main JJ cord-010092-uftc8inx 8909 10 parameter parameter NN cord-010092-uftc8inx 8909 11 for for IN cord-010092-uftc8inx 8909 12 selecting select VBG cord-010092-uftc8inx 8909 13 those those DT cord-010092-uftc8inx 8909 14 samples sample NNS cord-010092-uftc8inx 8909 15 to to IN cord-010092-uftc8inx 8909 16 eluate eluate NNP cord-010092-uftc8inx 8909 17 . . . cord-010092-uftc8inx 8910 1 Besides besides IN cord-010092-uftc8inx 8910 2 ensuring ensure VBG cord-010092-uftc8inx 8910 3 that that IN cord-010092-uftc8inx 8910 4 no no DT cord-010092-uftc8inx 8910 5 clinically clinically RB cord-010092-uftc8inx 8910 6 relevant relevant JJ cord-010092-uftc8inx 8910 7 samples sample NNS cord-010092-uftc8inx 8910 8 were be VBD cord-010092-uftc8inx 8910 9 missed miss VBN cord-010092-uftc8inx 8910 10 , , , cord-010092-uftc8inx 8910 11 this this DT cord-010092-uftc8inx 8910 12 strategy strategy NN cord-010092-uftc8inx 8910 13 also also RB cord-010092-uftc8inx 8910 14 led lead VBD cord-010092-uftc8inx 8910 15 to to IN cord-010092-uftc8inx 8910 16 a a DT cord-010092-uftc8inx 8910 17 large large JJ cord-010092-uftc8inx 8910 18 number number NN cord-010092-uftc8inx 8910 19 of of IN cord-010092-uftc8inx 8910 20 unnecessary unnecessary JJ cord-010092-uftc8inx 8910 21 elution elution NN cord-010092-uftc8inx 8910 22 analyses analysis NNS cord-010092-uftc8inx 8910 23 . . . cord-010092-uftc8inx 8911 1 In in IN cord-010092-uftc8inx 8911 2 conclusion conclusion NN cord-010092-uftc8inx 8911 3 , , , cord-010092-uftc8inx 8911 4 a a DT cord-010092-uftc8inx 8911 5 significant significant JJ cord-010092-uftc8inx 8911 6 reduction reduction NN cord-010092-uftc8inx 8911 7 in in IN cord-010092-uftc8inx 8911 8 the the DT cord-010092-uftc8inx 8911 9 laboratory laboratory NN cord-010092-uftc8inx 8911 10 workload workload NN cord-010092-uftc8inx 8911 11 and and CC cord-010092-uftc8inx 8911 12 economical economical JJ cord-010092-uftc8inx 8911 13 savings saving NNS cord-010092-uftc8inx 8911 14 arises arise VBZ cord-010092-uftc8inx 8911 15 if if IN cord-010092-uftc8inx 8911 16 the the DT cord-010092-uftc8inx 8911 17 relevant relevant JJ cord-010092-uftc8inx 8911 18 clinical clinical JJ cord-010092-uftc8inx 8911 19 information information NN cord-010092-uftc8inx 8911 20 and and CC cord-010092-uftc8inx 8911 21 patients patient NNS cord-010092-uftc8inx 8911 22 history history NN cord-010092-uftc8inx 8911 23 is be VBZ cord-010092-uftc8inx 8911 24 known know VBN cord-010092-uftc8inx 8911 25 prior prior RB cord-010092-uftc8inx 8911 26 to to IN cord-010092-uftc8inx 8911 27 laboratory laboratory NN cord-010092-uftc8inx 8911 28 analysis analysis NN cord-010092-uftc8inx 8911 29 . . . cord-010092-uftc8inx 8912 1 Background background NN cord-010092-uftc8inx 8912 2 : : : cord-010092-uftc8inx 8913 1 Novel novel JJ cord-010092-uftc8inx 8913 2 anti anti JJ cord-010092-uftc8inx 8913 3 - - JJ cord-010092-uftc8inx 8913 4 CD38 cd38 JJ cord-010092-uftc8inx 8913 5 monoclonal monoclonal JJ cord-010092-uftc8inx 8913 6 antibodies antibody NNS cord-010092-uftc8inx 8913 7 , , , cord-010092-uftc8inx 8913 8 such such JJ cord-010092-uftc8inx 8913 9 as as IN cord-010092-uftc8inx 8913 10 daratumumab daratumumab NNP cord-010092-uftc8inx 8913 11 ( ( -LRB- cord-010092-uftc8inx 8913 12 DARA DARA NNP cord-010092-uftc8inx 8913 13 ) ) -RRB- cord-010092-uftc8inx 8913 14 and and CC cord-010092-uftc8inx 8913 15 Isatuximab Isatuximab NNP cord-010092-uftc8inx 8913 16 , , , cord-010092-uftc8inx 8913 17 used use VBN cord-010092-uftc8inx 8913 18 in in IN cord-010092-uftc8inx 8913 19 treatment treatment NN cord-010092-uftc8inx 8913 20 of of IN cord-010092-uftc8inx 8913 21 multiple multiple JJ cord-010092-uftc8inx 8913 22 myeloma myeloma NN cord-010092-uftc8inx 8913 23 , , , cord-010092-uftc8inx 8913 24 interfere interfere VB cord-010092-uftc8inx 8913 25 with with IN cord-010092-uftc8inx 8913 26 routine routine JJ cord-010092-uftc8inx 8913 27 blood blood NN cord-010092-uftc8inx 8913 28 bank bank NN cord-010092-uftc8inx 8913 29 serologic serologic NNP cord-010092-uftc8inx 8913 30 tests test NNS cord-010092-uftc8inx 8913 31 . . . cord-010092-uftc8inx 8914 1 As as IN cord-010092-uftc8inx 8914 2 part part NN cord-010092-uftc8inx 8914 3 of of IN cord-010092-uftc8inx 8914 4 the the DT cord-010092-uftc8inx 8914 5 strategies strategy NNS cord-010092-uftc8inx 8914 6 to to TO cord-010092-uftc8inx 8914 7 manage manage VB cord-010092-uftc8inx 8914 8 these these DT cord-010092-uftc8inx 8914 9 patients patient NNS cord-010092-uftc8inx 8914 10 , , , cord-010092-uftc8inx 8914 11 it -PRON- PRP cord-010092-uftc8inx 8914 12 is be VBZ cord-010092-uftc8inx 8914 13 recommended recommend VBN cord-010092-uftc8inx 8914 14 to to TO cord-010092-uftc8inx 8914 15 perform perform VB cord-010092-uftc8inx 8914 16 extended extended JJ cord-010092-uftc8inx 8914 17 phenotyping phenotyping NN cord-010092-uftc8inx 8914 18 to to TO cord-010092-uftc8inx 8914 19 provide provide VB cord-010092-uftc8inx 8914 20 matched matched JJ cord-010092-uftc8inx 8914 21 units unit NNS cord-010092-uftc8inx 8914 22 ( ( -LRB- cord-010092-uftc8inx 8914 23 AABB AABB NNP cord-010092-uftc8inx 8914 24 Association Association NNP cord-010092-uftc8inx 8914 25 Bulletin Bulletin NNP cord-010092-uftc8inx 8914 26 # # $ cord-010092-uftc8inx 8914 27 16 16 CD cord-010092-uftc8inx 8914 28 - - SYM cord-010092-uftc8inx 8914 29 02 02 CD cord-010092-uftc8inx 8914 30 ) ) -RRB- cord-010092-uftc8inx 8914 31 . . . cord-010092-uftc8inx 8915 1 Many many JJ cord-010092-uftc8inx 8915 2 investigations investigation NNS cord-010092-uftc8inx 8915 3 have have VBP cord-010092-uftc8inx 8915 4 focused focus VBN cord-010092-uftc8inx 8915 5 on on IN cord-010092-uftc8inx 8915 6 the the DT cord-010092-uftc8inx 8915 7 interference interference NN cord-010092-uftc8inx 8915 8 with with IN cord-010092-uftc8inx 8915 9 IAT IAT NNP cord-010092-uftc8inx 8915 10 for for IN cord-010092-uftc8inx 8915 11 the the DT cord-010092-uftc8inx 8915 12 screening screening NN cord-010092-uftc8inx 8915 13 and and CC cord-010092-uftc8inx 8915 14 identification identification NN cord-010092-uftc8inx 8915 15 of of IN cord-010092-uftc8inx 8915 16 underlying underlie VBG cord-010092-uftc8inx 8915 17 alloantibodies alloantibody NNS cord-010092-uftc8inx 8915 18 and and CC cord-010092-uftc8inx 8915 19 how how WRB cord-010092-uftc8inx 8915 20 to to TO cord-010092-uftc8inx 8915 21 overcome overcome VB cord-010092-uftc8inx 8915 22 them -PRON- PRP cord-010092-uftc8inx 8915 23 , , , cord-010092-uftc8inx 8915 24 but but CC cord-010092-uftc8inx 8915 25 less less JJR cord-010092-uftc8inx 8915 26 has have VBZ cord-010092-uftc8inx 8915 27 been be VBN cord-010092-uftc8inx 8915 28 published publish VBN cord-010092-uftc8inx 8915 29 on on IN cord-010092-uftc8inx 8915 30 the the DT cord-010092-uftc8inx 8915 31 potential potential JJ cord-010092-uftc8inx 8915 32 interference interference NN cord-010092-uftc8inx 8915 33 with with IN cord-010092-uftc8inx 8915 34 extended extended JJ cord-010092-uftc8inx 8915 35 phenotyping phenotyping NN cord-010092-uftc8inx 8915 36 techniques technique NNS cord-010092-uftc8inx 8915 37 . . . cord-010092-uftc8inx 8916 1 Aims aim VBZ cord-010092-uftc8inx 8916 2 : : : cord-010092-uftc8inx 8917 1 The the DT cord-010092-uftc8inx 8917 2 purpose purpose NN cord-010092-uftc8inx 8917 3 of of IN cord-010092-uftc8inx 8917 4 this this DT cord-010092-uftc8inx 8917 5 study study NN cord-010092-uftc8inx 8917 6 is be VBZ cord-010092-uftc8inx 8917 7 to to TO cord-010092-uftc8inx 8917 8 compare compare VB cord-010092-uftc8inx 8917 9 different different JJ cord-010092-uftc8inx 8917 10 technologies technology NNS cord-010092-uftc8inx 8917 11 to to TO cord-010092-uftc8inx 8917 12 type type VB cord-010092-uftc8inx 8917 13 the the DT cord-010092-uftc8inx 8917 14 most most RBS cord-010092-uftc8inx 8917 15 important important JJ cord-010092-uftc8inx 8917 16 antigens antigen NNS cord-010092-uftc8inx 8917 17 in in IN cord-010092-uftc8inx 8917 18 myeloma myeloma NN cord-010092-uftc8inx 8917 19 patients patient NNS cord-010092-uftc8inx 8917 20 before before IN cord-010092-uftc8inx 8917 21 and and CC cord-010092-uftc8inx 8917 22 during during IN cord-010092-uftc8inx 8917 23 the the DT cord-010092-uftc8inx 8917 24 treatment treatment NN cord-010092-uftc8inx 8917 25 with with IN cord-010092-uftc8inx 8917 26 therapeutic therapeutic JJ cord-010092-uftc8inx 8917 27 anti anti JJ cord-010092-uftc8inx 8917 28 - - JJ cord-010092-uftc8inx 8917 29 CD38 cd38 JJ cord-010092-uftc8inx 8917 30 antibodies antibody NNS cord-010092-uftc8inx 8917 31 . . . cord-010092-uftc8inx 8918 1 Vox Vox NNP cord-010092-uftc8inx 8918 2 Sanguinis Sanguinis NNP cord-010092-uftc8inx 8918 3 ( ( -LRB- cord-010092-uftc8inx 8918 4 2019 2019 CD cord-010092-uftc8inx 8918 5 ) ) -RRB- cord-010092-uftc8inx 8918 6 114 114 CD cord-010092-uftc8inx 8918 7 ( ( -LRB- cord-010092-uftc8inx 8918 8 Suppl Suppl NNP cord-010092-uftc8inx 8918 9 . . NNP cord-010092-uftc8inx 8918 10 1 1 CD cord-010092-uftc8inx 8918 11 ) ) -RRB- cord-010092-uftc8inx 8918 12 , , , cord-010092-uftc8inx 8918 13 5 5 CD cord-010092-uftc8inx 8918 14 - - SYM cord-010092-uftc8inx 8918 15 240 240 CD cord-010092-uftc8inx 8918 16 Methods method NNS cord-010092-uftc8inx 8918 17 : : : cord-010092-uftc8inx 8918 18 EDTA edta NN cord-010092-uftc8inx 8918 19 - - HYPH cord-010092-uftc8inx 8918 20 anticoagulated anticoagulate VBN cord-010092-uftc8inx 8918 21 whole whole JJ cord-010092-uftc8inx 8918 22 blood blood NN cord-010092-uftc8inx 8918 23 samples sample NNS cord-010092-uftc8inx 8918 24 coming come VBG cord-010092-uftc8inx 8918 25 from from IN cord-010092-uftc8inx 8918 26 30 30 CD cord-010092-uftc8inx 8918 27 patients patient NNS cord-010092-uftc8inx 8918 28 in in IN cord-010092-uftc8inx 8918 29 different different JJ cord-010092-uftc8inx 8918 30 stages stage NNS cord-010092-uftc8inx 8918 31 of of IN cord-010092-uftc8inx 8918 32 treatment treatment NN cord-010092-uftc8inx 8918 33 with with IN cord-010092-uftc8inx 8918 34 Daratumumab Daratumumab NNP cord-010092-uftc8inx 8918 35 and and CC cord-010092-uftc8inx 8918 36 5 5 CD cord-010092-uftc8inx 8918 37 with with IN cord-010092-uftc8inx 8918 38 Isatuximab Isatuximab NNP cord-010092-uftc8inx 8918 39 have have VBP cord-010092-uftc8inx 8918 40 been be VBN cord-010092-uftc8inx 8918 41 typed type VBN cord-010092-uftc8inx 8918 42 in in IN cord-010092-uftc8inx 8918 43 parallel parallel NN cord-010092-uftc8inx 8918 44 with with IN cord-010092-uftc8inx 8918 45 DG DG NNP cord-010092-uftc8inx 8918 46 Gel Gel NNP cord-010092-uftc8inx 8918 47 microcolumn microcolumn NN cord-010092-uftc8inx 8918 48 ( ( -LRB- cord-010092-uftc8inx 8918 49 Grifols Grifols NNP cord-010092-uftc8inx 8918 50 ) ) -RRB- cord-010092-uftc8inx 8918 51 and and CC cord-010092-uftc8inx 8918 52 MDmulticard MDmulticard NNP cord-010092-uftc8inx 8918 53 technology technology NN cord-010092-uftc8inx 8918 54 ( ( -LRB- cord-010092-uftc8inx 8918 55 Grifols Grifols NNP cord-010092-uftc8inx 8918 56 ) ) -RRB- cord-010092-uftc8inx 8918 57 . . . cord-010092-uftc8inx 8919 1 The the DT cord-010092-uftc8inx 8919 2 results result NNS cord-010092-uftc8inx 8919 3 are be VBP cord-010092-uftc8inx 8919 4 also also RB cord-010092-uftc8inx 8919 5 compared compare VBN cord-010092-uftc8inx 8919 6 with with IN cord-010092-uftc8inx 8919 7 genotyping genotyping NN cord-010092-uftc8inx 8919 8 results result NNS cord-010092-uftc8inx 8919 9 obtained obtain VBN cord-010092-uftc8inx 8919 10 with with IN cord-010092-uftc8inx 8919 11 ID ID NNP cord-010092-uftc8inx 8919 12 CORE CORE NNP cord-010092-uftc8inx 8919 13 XT XT NNP cord-010092-uftc8inx 8919 14 ( ( -LRB- cord-010092-uftc8inx 8919 15 Grifols Grifols NNP cord-010092-uftc8inx 8919 16 ) ) -RRB- cord-010092-uftc8inx 8919 17 . . . cord-010092-uftc8inx 8920 1 Direct Direct NNP cord-010092-uftc8inx 8920 2 Coombs Coombs NNP cord-010092-uftc8inx 8920 3 , , , cord-010092-uftc8inx 8920 4 Autocontrol Autocontrol NNP cord-010092-uftc8inx 8920 5 and and CC cord-010092-uftc8inx 8920 6 antibody antibody NN cord-010092-uftc8inx 8920 7 screening screening NN cord-010092-uftc8inx 8920 8 has have VBZ cord-010092-uftc8inx 8920 9 also also RB cord-010092-uftc8inx 8920 10 been be VBN cord-010092-uftc8inx 8920 11 performed perform VBN cord-010092-uftc8inx 8920 12 as as IN cord-010092-uftc8inx 8920 13 complementary complementary JJ cord-010092-uftc8inx 8920 14 tests test NNS cord-010092-uftc8inx 8920 15 . . . cord-010092-uftc8inx 8921 1 Results result NNS cord-010092-uftc8inx 8921 2 : : : cord-010092-uftc8inx 8922 1 The the DT cord-010092-uftc8inx 8922 2 study study NN cord-010092-uftc8inx 8922 3 provides provide VBZ cord-010092-uftc8inx 8922 4 that that IN cord-010092-uftc8inx 8922 5 four four CD cord-010092-uftc8inx 8922 6 patients patient NNS cord-010092-uftc8inx 8922 7 had have VBD cord-010092-uftc8inx 8922 8 positive positive JJ cord-010092-uftc8inx 8922 9 DAT DAT NNP cord-010092-uftc8inx 8922 10 and/or and/or CC cord-010092-uftc8inx 8922 11 AC ac NN cord-010092-uftc8inx 8922 12 before before IN cord-010092-uftc8inx 8922 13 therapeutic therapeutic JJ cord-010092-uftc8inx 8922 14 CD38 CD38 NNP cord-010092-uftc8inx 8922 15 antibodies antibody NNS cord-010092-uftc8inx 8922 16 treatment treatment NN cord-010092-uftc8inx 8922 17 . . . cord-010092-uftc8inx 8923 1 In in IN cord-010092-uftc8inx 8923 2 these these DT cord-010092-uftc8inx 8923 3 cases case NNS cord-010092-uftc8inx 8923 4 , , , cord-010092-uftc8inx 8923 5 6 6 CD cord-010092-uftc8inx 8923 6 of of IN cord-010092-uftc8inx 8923 7 7 7 CD cord-010092-uftc8inx 8923 8 negative negative JJ cord-010092-uftc8inx 8923 9 antigens antigen NNS cord-010092-uftc8inx 8923 10 ( ( -LRB- cord-010092-uftc8inx 8923 11 Fy Fy NNP cord-010092-uftc8inx 8923 12 / / SYM cord-010092-uftc8inx 8923 13 Jk Jk NNP cord-010092-uftc8inx 8924 1 and/or and/or CC cord-010092-uftc8inx 8924 2 S S NNP cord-010092-uftc8inx 8924 3 ) ) -RRB- cord-010092-uftc8inx 8924 4 turn turn VBP cord-010092-uftc8inx 8924 5 to to IN cord-010092-uftc8inx 8924 6 positive positive JJ cord-010092-uftc8inx 8924 7 in in IN cord-010092-uftc8inx 8924 8 gel gel NN cord-010092-uftc8inx 8924 9 technology technology NN cord-010092-uftc8inx 8924 10 but but CC cord-010092-uftc8inx 8924 11 MDmulticard MDmulticard NNP cord-010092-uftc8inx 8924 12 showed show VBD cord-010092-uftc8inx 8924 13 100 100 CD cord-010092-uftc8inx 8924 14 % % NN cord-010092-uftc8inx 8924 15 agreement agreement NN cord-010092-uftc8inx 8924 16 with with IN cord-010092-uftc8inx 8924 17 genotype genotype NN cord-010092-uftc8inx 8924 18 ID ID NNP cord-010092-uftc8inx 8924 19 CORE core NN cord-010092-uftc8inx 8924 20 XT XT NNP cord-010092-uftc8inx 8924 21 results result NNS cord-010092-uftc8inx 8924 22 . . . cord-010092-uftc8inx 8925 1 Focusing focus VBG cord-010092-uftc8inx 8925 2 in in IN cord-010092-uftc8inx 8925 3 the the DT cord-010092-uftc8inx 8925 4 data datum NNS cord-010092-uftc8inx 8925 5 obtained obtain VBN cord-010092-uftc8inx 8925 6 during during IN cord-010092-uftc8inx 8925 7 the the DT cord-010092-uftc8inx 8925 8 treatment treatment NN cord-010092-uftc8inx 8925 9 , , , cord-010092-uftc8inx 8925 10 8 8 CD cord-010092-uftc8inx 8925 11 negative negative JJ cord-010092-uftc8inx 8925 12 antigens antigen NNS cord-010092-uftc8inx 8925 13 were be VBD cord-010092-uftc8inx 8925 14 type type NN cord-010092-uftc8inx 8925 15 as as IN cord-010092-uftc8inx 8925 16 positive positive JJ cord-010092-uftc8inx 8925 17 in in IN cord-010092-uftc8inx 8925 18 gel gel NN cord-010092-uftc8inx 8925 19 technology technology NN cord-010092-uftc8inx 8925 20 ( ( -LRB- cord-010092-uftc8inx 8925 21 12 12 CD cord-010092-uftc8inx 8925 22 % % NN cord-010092-uftc8inx 8925 23 of of IN cord-010092-uftc8inx 8925 24 the the DT cord-010092-uftc8inx 8925 25 tests test NNS cord-010092-uftc8inx 8925 26 ) ) -RRB- cord-010092-uftc8inx 8925 27 . . . cord-010092-uftc8inx 8926 1 MDmulticard MDmulticard NNP cord-010092-uftc8inx 8926 2 agreed agree VBD cord-010092-uftc8inx 8926 3 with with IN cord-010092-uftc8inx 8926 4 genotype genotype NN cord-010092-uftc8inx 8926 5 in in IN cord-010092-uftc8inx 8926 6 100 100 CD cord-010092-uftc8inx 8926 7 % % NN cord-010092-uftc8inx 8926 8 of of IN cord-010092-uftc8inx 8926 9 the the DT cord-010092-uftc8inx 8926 10 analyzed analyze VBN cord-010092-uftc8inx 8926 11 antigens antigen NNS cord-010092-uftc8inx 8926 12 . . . cord-010092-uftc8inx 8927 1 As as IN cord-010092-uftc8inx 8927 2 complementary complementary JJ cord-010092-uftc8inx 8927 3 data datum NNS cord-010092-uftc8inx 8927 4 , , , cord-010092-uftc8inx 8927 5 13 13 CD cord-010092-uftc8inx 8927 6 of of IN cord-010092-uftc8inx 8927 7 66 66 CD cord-010092-uftc8inx 8927 8 patient patient NN cord-010092-uftc8inx 8927 9 - - HYPH cord-010092-uftc8inx 8927 10 treated treat VBN cord-010092-uftc8inx 8927 11 samples sample NNS cord-010092-uftc8inx 8927 12 had have VBD cord-010092-uftc8inx 8927 13 DAT DAT NNP cord-010092-uftc8inx 8927 14 or or CC cord-010092-uftc8inx 8927 15 AC AC NNP cord-010092-uftc8inx 8927 16 positive positive JJ cord-010092-uftc8inx 8927 17 and and CC cord-010092-uftc8inx 8927 18 59 59 CD cord-010092-uftc8inx 8927 19 showed show VBD cord-010092-uftc8inx 8927 20 panagglutination panagglutination NN cord-010092-uftc8inx 8927 21 . . . cord-010092-uftc8inx 8928 1 Summary Summary NNP cord-010092-uftc8inx 8928 2 / / SYM cord-010092-uftc8inx 8928 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 8928 4 : : : cord-010092-uftc8inx 8929 1 The the DT cord-010092-uftc8inx 8929 2 results result NNS cord-010092-uftc8inx 8929 3 demonstrated demonstrate VBD cord-010092-uftc8inx 8929 4 that that IN cord-010092-uftc8inx 8929 5 MDmulticard MDmulticard NNP cord-010092-uftc8inx 8929 6 is be VBZ cord-010092-uftc8inx 8929 7 an an DT cord-010092-uftc8inx 8929 8 effective effective JJ cord-010092-uftc8inx 8929 9 method method NN cord-010092-uftc8inx 8929 10 to to TO cord-010092-uftc8inx 8929 11 type type VB cord-010092-uftc8inx 8929 12 CD38-directed cd38-directed CD cord-010092-uftc8inx 8929 13 cytolytic cytolytic JJ cord-010092-uftc8inx 8929 14 antibodies antibody NNS cord-010092-uftc8inx 8929 15 treated treat VBD cord-010092-uftc8inx 8929 16 samples sample NNS cord-010092-uftc8inx 8929 17 in in IN cord-010092-uftc8inx 8929 18 addition addition NN cord-010092-uftc8inx 8929 19 to to IN cord-010092-uftc8inx 8929 20 DAT DAT NNP cord-010092-uftc8inx 8929 21 and and CC cord-010092-uftc8inx 8929 22 or or CC cord-010092-uftc8inx 8929 23 Autocontrol Autocontrol NNP cord-010092-uftc8inx 8929 24 positive positive JJ cord-010092-uftc8inx 8929 25 samples sample NNS cord-010092-uftc8inx 8929 26 . . . cord-010092-uftc8inx 8930 1 Background background NN cord-010092-uftc8inx 8930 2 : : : cord-010092-uftc8inx 8931 1 Antibody antibody NN cord-010092-uftc8inx 8931 2 titration titration NN cord-010092-uftc8inx 8931 3 is be VBZ cord-010092-uftc8inx 8931 4 a a DT cord-010092-uftc8inx 8931 5 semi semi JJ cord-010092-uftc8inx 8931 6 - - JJ cord-010092-uftc8inx 8931 7 quantitative quantitative JJ cord-010092-uftc8inx 8931 8 method method NN cord-010092-uftc8inx 8931 9 to to TO cord-010092-uftc8inx 8931 10 estimate estimate VB cord-010092-uftc8inx 8931 11 the the DT cord-010092-uftc8inx 8931 12 strength strength NN cord-010092-uftc8inx 8931 13 and and CC cord-010092-uftc8inx 8931 14 concentration concentration NN cord-010092-uftc8inx 8931 15 of of IN cord-010092-uftc8inx 8931 16 antibodies antibody NNS cord-010092-uftc8inx 8931 17 present present JJ cord-010092-uftc8inx 8931 18 in in IN cord-010092-uftc8inx 8931 19 plasma plasma NN cord-010092-uftc8inx 8931 20 or or CC cord-010092-uftc8inx 8931 21 serum serum NN cord-010092-uftc8inx 8931 22 sample sample NN cord-010092-uftc8inx 8931 23 . . . cord-010092-uftc8inx 8932 1 Titration titration NN cord-010092-uftc8inx 8932 2 methodology methodology NN cord-010092-uftc8inx 8932 3 should should MD cord-010092-uftc8inx 8932 4 be be VB cord-010092-uftc8inx 8932 5 validated validate VBN cord-010092-uftc8inx 8932 6 together together RB cord-010092-uftc8inx 8932 7 with with IN cord-010092-uftc8inx 8932 8 clinical clinical JJ cord-010092-uftc8inx 8932 9 data datum NNS cord-010092-uftc8inx 8932 10 to to TO cord-010092-uftc8inx 8932 11 evaluate evaluate VB cord-010092-uftc8inx 8932 12 the the DT cord-010092-uftc8inx 8932 13 relevance relevance NN cord-010092-uftc8inx 8932 14 of of IN cord-010092-uftc8inx 8932 15 the the DT cord-010092-uftc8inx 8932 16 titer titer NN cord-010092-uftc8inx 8932 17 value value NN cord-010092-uftc8inx 8932 18 in in IN cord-010092-uftc8inx 8932 19 each each DT cord-010092-uftc8inx 8932 20 application application NN cord-010092-uftc8inx 8932 21 . . . cord-010092-uftc8inx 8933 1 The the DT cord-010092-uftc8inx 8933 2 titer titer NN cord-010092-uftc8inx 8933 3 of of IN cord-010092-uftc8inx 8933 4 an an DT cord-010092-uftc8inx 8933 5 antibody antibody NN cord-010092-uftc8inx 8933 6 depends depend VBZ cord-010092-uftc8inx 8933 7 on on IN cord-010092-uftc8inx 8933 8 different different JJ cord-010092-uftc8inx 8933 9 parameters parameter NNS cord-010092-uftc8inx 8933 10 : : : cord-010092-uftc8inx 8934 1 the the DT cord-010092-uftc8inx 8934 2 antibody antibody NN cord-010092-uftc8inx 8934 3 concentration concentration NN cord-010092-uftc8inx 8934 4 in in IN cord-010092-uftc8inx 8934 5 the the DT cord-010092-uftc8inx 8934 6 sample sample NN cord-010092-uftc8inx 8934 7 , , , cord-010092-uftc8inx 8934 8 the the DT cord-010092-uftc8inx 8934 9 density density NN cord-010092-uftc8inx 8934 10 of of IN cord-010092-uftc8inx 8934 11 the the DT cord-010092-uftc8inx 8934 12 corresponding correspond VBG cord-010092-uftc8inx 8934 13 antigen antigen NN cord-010092-uftc8inx 8934 14 expressed express VBN cord-010092-uftc8inx 8934 15 on on IN cord-010092-uftc8inx 8934 16 the the DT cord-010092-uftc8inx 8934 17 red red JJ cord-010092-uftc8inx 8934 18 blood blood NN cord-010092-uftc8inx 8934 19 cells cell NNS cord-010092-uftc8inx 8934 20 used use VBN cord-010092-uftc8inx 8934 21 , , , cord-010092-uftc8inx 8934 22 the the DT cord-010092-uftc8inx 8934 23 affinity affinity NN cord-010092-uftc8inx 8934 24 constant constant NN cord-010092-uftc8inx 8934 25 of of IN cord-010092-uftc8inx 8934 26 the the DT cord-010092-uftc8inx 8934 27 antibody antibody NN cord-010092-uftc8inx 8934 28 - - HYPH cord-010092-uftc8inx 8934 29 antigen antigen NN cord-010092-uftc8inx 8934 30 and and CC cord-010092-uftc8inx 8934 31 other other JJ cord-010092-uftc8inx 8934 32 parameters parameter NNS cord-010092-uftc8inx 8934 33 regarding regard VBG cord-010092-uftc8inx 8934 34 the the DT cord-010092-uftc8inx 8934 35 technique technique NN cord-010092-uftc8inx 8934 36 used use VBN cord-010092-uftc8inx 8934 37 ( ( -LRB- cord-010092-uftc8inx 8934 38 e.g. e.g. IN cord-010092-uftc8inx 8934 39 gel gel NN cord-010092-uftc8inx 8934 40 cards card NNS cord-010092-uftc8inx 8934 41 or or CC cord-010092-uftc8inx 8934 42 tube tube NN cord-010092-uftc8inx 8934 43 test test NN cord-010092-uftc8inx 8934 44 ) ) -RRB- cord-010092-uftc8inx 8934 45 . . . cord-010092-uftc8inx 8935 1 Gel gel NN cord-010092-uftc8inx 8935 2 cards card NNS cord-010092-uftc8inx 8935 3 technology technology NN cord-010092-uftc8inx 8935 4 reduces reduce VBZ cord-010092-uftc8inx 8935 5 the the DT cord-010092-uftc8inx 8935 6 intra intra JJ cord-010092-uftc8inx 8935 7 and and CC cord-010092-uftc8inx 8935 8 inter inter JJ cord-010092-uftc8inx 8935 9 - - JJ cord-010092-uftc8inx 8935 10 laboratory laboratory JJ cord-010092-uftc8inx 8935 11 variation variation NN cord-010092-uftc8inx 8935 12 in in IN cord-010092-uftc8inx 8935 13 titration titration NN cord-010092-uftc8inx 8935 14 studies study NNS cord-010092-uftc8inx 8935 15 comparing compare VBG cord-010092-uftc8inx 8935 16 with with IN cord-010092-uftc8inx 8935 17 the the DT cord-010092-uftc8inx 8935 18 tube tube NN cord-010092-uftc8inx 8935 19 technique technique NN cord-010092-uftc8inx 8935 20 . . . cord-010092-uftc8inx 8936 1 Aims aim VBZ cord-010092-uftc8inx 8936 2 : : : cord-010092-uftc8inx 8936 3 To to TO cord-010092-uftc8inx 8936 4 evaluate evaluate VB cord-010092-uftc8inx 8936 5 the the DT cord-010092-uftc8inx 8936 6 suitability suitability NN cord-010092-uftc8inx 8936 7 of of IN cord-010092-uftc8inx 8936 8 DG DG NNP cord-010092-uftc8inx 8936 9 Gel Gel NNP cord-010092-uftc8inx 8936 10 Coombs Coombs NNP cord-010092-uftc8inx 8936 11 , , , cord-010092-uftc8inx 8936 12 DG DG NNP cord-010092-uftc8inx 8936 13 Gel Gel NNP cord-010092-uftc8inx 8936 14 Anti Anti NNP cord-010092-uftc8inx 8936 15 - - JJ cord-010092-uftc8inx 8936 16 IgG IgG NNP cord-010092-uftc8inx 8936 17 and and CC cord-010092-uftc8inx 8936 18 DG DG NNP cord-010092-uftc8inx 8936 19 Gel Gel NNP cord-010092-uftc8inx 8936 20 Neutral Neutral NNP cord-010092-uftc8inx 8936 21 ( ( -LRB- cord-010092-uftc8inx 8936 22 Grifols Grifols NNP cord-010092-uftc8inx 8936 23 ) ) -RRB- cord-010092-uftc8inx 8936 24 for for IN cord-010092-uftc8inx 8936 25 titrations titration NNS cord-010092-uftc8inx 8936 26 using use VBG cord-010092-uftc8inx 8936 27 two two CD cord-010092-uftc8inx 8936 28 sample sample NN cord-010092-uftc8inx 8936 29 volumes volume NNS cord-010092-uftc8inx 8936 30 25 25 CD cord-010092-uftc8inx 8936 31 lL lL NNS cord-010092-uftc8inx 8936 32 and and CC cord-010092-uftc8inx 8936 33 50 50 CD cord-010092-uftc8inx 8936 34 lL. ll. NN cord-010092-uftc8inx 8936 35 Methods method NNS cord-010092-uftc8inx 8936 36 : : : cord-010092-uftc8inx 8937 1 Twenty twenty CD cord-010092-uftc8inx 8937 2 frozen frozen JJ cord-010092-uftc8inx 8937 3 plasma plasma NN cord-010092-uftc8inx 8937 4 samples sample NNS cord-010092-uftc8inx 8937 5 containing contain VBG cord-010092-uftc8inx 8937 6 unexpected unexpected JJ cord-010092-uftc8inx 8937 7 antibodies antibody NNS cord-010092-uftc8inx 8937 8 from from IN cord-010092-uftc8inx 8937 9 different different JJ cord-010092-uftc8inx 8937 10 specificities specificity NNS cord-010092-uftc8inx 8937 11 ( ( -LRB- cord-010092-uftc8inx 8937 12 anti anti JJ cord-010092-uftc8inx 8937 13 - - JJ cord-010092-uftc8inx 8937 14 Jk Jk NNP cord-010092-uftc8inx 8937 15 a a DT cord-010092-uftc8inx 8937 16 , , , cord-010092-uftc8inx 8937 17 -Fy -Fy NNP cord-010092-uftc8inx 8937 18 a a DT cord-010092-uftc8inx 8937 19 , , , cord-010092-uftc8inx 8937 20 -K -k ADD cord-010092-uftc8inx 8937 21 , , , cord-010092-uftc8inx 8937 22 -D -d NN cord-010092-uftc8inx 8937 23 , , , cord-010092-uftc8inx 8937 24 -E -e ADD cord-010092-uftc8inx 8937 25 and and CC cord-010092-uftc8inx 8937 26 -c -c LS cord-010092-uftc8inx 8937 27 ) ) -RRB- cord-010092-uftc8inx 8937 28 were be VBD cord-010092-uftc8inx 8937 29 titrated titrate VBN cord-010092-uftc8inx 8937 30 in in IN cord-010092-uftc8inx 8937 31 DG DG NNP cord-010092-uftc8inx 8937 32 Gel Gel NNP cord-010092-uftc8inx 8937 33 Coombs Coombs NNP cord-010092-uftc8inx 8937 34 and and CC cord-010092-uftc8inx 8937 35 DG DG NNP cord-010092-uftc8inx 8937 36 Gel Gel NNP cord-010092-uftc8inx 8937 37 Anti Anti NNP cord-010092-uftc8inx 8937 38 - - JJ cord-010092-uftc8inx 8937 39 IgG igg JJ cord-010092-uftc8inx 8937 40 cards card NNS cord-010092-uftc8inx 8937 41 and and CC cord-010092-uftc8inx 8937 42 20 20 CD cord-010092-uftc8inx 8937 43 donor donor NN cord-010092-uftc8inx 8937 44 fresh fresh JJ cord-010092-uftc8inx 8937 45 plasmas plasma NNS cord-010092-uftc8inx 8937 46 with with IN cord-010092-uftc8inx 8937 47 natural natural JJ cord-010092-uftc8inx 8937 48 occurring occur VBG cord-010092-uftc8inx 8937 49 antibodies antibody NNS cord-010092-uftc8inx 8937 50 ( ( -LRB- cord-010092-uftc8inx 8937 51 anti anti JJ cord-010092-uftc8inx 8937 52 - - JJ cord-010092-uftc8inx 8937 53 A a NN cord-010092-uftc8inx 8937 54 and and CC cord-010092-uftc8inx 8937 55 -B -b ADD cord-010092-uftc8inx 8937 56 ) ) -RRB- cord-010092-uftc8inx 8938 1 were be VBD cord-010092-uftc8inx 8938 2 titrated titrate VBN cord-010092-uftc8inx 8938 3 in in IN cord-010092-uftc8inx 8938 4 DG DG NNP cord-010092-uftc8inx 8938 5 Gel Gel NNP cord-010092-uftc8inx 8938 6 Coombs Coombs NNP cord-010092-uftc8inx 8938 7 and and CC cord-010092-uftc8inx 8938 8 DG DG NNP cord-010092-uftc8inx 8938 9 Gel Gel NNP cord-010092-uftc8inx 8938 10 Neutral Neutral NNP cord-010092-uftc8inx 8938 11 ( ( -LRB- cord-010092-uftc8inx 8938 12 saline saline NN cord-010092-uftc8inx 8938 13 technique technique NN cord-010092-uftc8inx 8938 14 ) ) -RRB- cord-010092-uftc8inx 8938 15 . . . cord-010092-uftc8inx 8939 1 The the DT cord-010092-uftc8inx 8939 2 titer titer NN cord-010092-uftc8inx 8939 3 of of IN cord-010092-uftc8inx 8939 4 the the DT cord-010092-uftc8inx 8939 5 antibodies antibody NNS cord-010092-uftc8inx 8939 6 was be VBD cord-010092-uftc8inx 8939 7 determined determine VBN cord-010092-uftc8inx 8939 8 by by IN cord-010092-uftc8inx 8939 9 testing test VBG cord-010092-uftc8inx 8939 10 two two CD cord-010092-uftc8inx 8939 11 - - HYPH cord-010092-uftc8inx 8939 12 fold fold JJ cord-010092-uftc8inx 8939 13 dilutions dilution NNS cord-010092-uftc8inx 8939 14 of of IN cord-010092-uftc8inx 8939 15 the the DT cord-010092-uftc8inx 8939 16 plasma plasma NN cord-010092-uftc8inx 8939 17 with with IN cord-010092-uftc8inx 8939 18 selected select VBN cord-010092-uftc8inx 8939 19 red red JJ cord-010092-uftc8inx 8939 20 blood blood NN cord-010092-uftc8inx 8939 21 cells cell NNS cord-010092-uftc8inx 8939 22 depending depend VBG cord-010092-uftc8inx 8939 23 on on IN cord-010092-uftc8inx 8939 24 the the DT cord-010092-uftc8inx 8939 25 antibody antibody NN cord-010092-uftc8inx 8939 26 tested test VBN cord-010092-uftc8inx 8939 27 . . . cord-010092-uftc8inx 8940 1 Plasma plasma NN cord-010092-uftc8inx 8940 2 samples sample NNS cord-010092-uftc8inx 8940 3 were be VBD cord-010092-uftc8inx 8940 4 diluted dilute VBN cord-010092-uftc8inx 8940 5 in in IN cord-010092-uftc8inx 8940 6 DG DG NNP cord-010092-uftc8inx 8940 7 Gel Gel NNP cord-010092-uftc8inx 8940 8 Sol Sol NNP cord-010092-uftc8inx 8940 9 . . . cord-010092-uftc8inx 8941 1 Selected select VBN cord-010092-uftc8inx 8941 2 red red JJ cord-010092-uftc8inx 8941 3 blood blood NN cord-010092-uftc8inx 8941 4 cells cell NNS cord-010092-uftc8inx 8941 5 Serascan Serascan NNP cord-010092-uftc8inx 8941 6 Diana Diana NNP cord-010092-uftc8inx 8941 7 , , , cord-010092-uftc8inx 8941 8 Serigrup Serigrup NNP cord-010092-uftc8inx 8941 9 Diana Diana NNP cord-010092-uftc8inx 8941 10 or or CC cord-010092-uftc8inx 8941 11 donor donor NN cord-010092-uftc8inx 8941 12 blood blood NN cord-010092-uftc8inx 8941 13 were be VBD cord-010092-uftc8inx 8941 14 added add VBN cord-010092-uftc8inx 8941 15 into into IN cord-010092-uftc8inx 8941 16 the the DT cord-010092-uftc8inx 8941 17 card card NN cord-010092-uftc8inx 8941 18 ( ( -LRB- cord-010092-uftc8inx 8941 19 50 50 CD cord-010092-uftc8inx 8941 20 lL ll ADD cord-010092-uftc8inx 8941 21 at at IN cord-010092-uftc8inx 8941 22 0.8 0.8 CD cord-010092-uftc8inx 8941 23 % % NN cord-010092-uftc8inx 8941 24 ) ) -RRB- cord-010092-uftc8inx 8941 25 . . . cord-010092-uftc8inx 8942 1 Further further RB cord-010092-uftc8inx 8942 2 , , , cord-010092-uftc8inx 8942 3 sample sample NN cord-010092-uftc8inx 8942 4 dilutions dilution NNS cord-010092-uftc8inx 8942 5 were be VBD cord-010092-uftc8inx 8942 6 dispensed dispense VBN cord-010092-uftc8inx 8942 7 into into IN cord-010092-uftc8inx 8942 8 the the DT cord-010092-uftc8inx 8942 9 card card NN cord-010092-uftc8inx 8942 10 ( ( -LRB- cord-010092-uftc8inx 8942 11 25 25 CD cord-010092-uftc8inx 8942 12 lL lL NNS cord-010092-uftc8inx 8942 13 or or CC cord-010092-uftc8inx 8942 14 50 50 CD cord-010092-uftc8inx 8942 15 lL lL NNP cord-010092-uftc8inx 8942 16 ) ) -RRB- cord-010092-uftc8inx 8942 17 . . . cord-010092-uftc8inx 8943 1 Subsequently subsequently RB cord-010092-uftc8inx 8943 2 , , , cord-010092-uftc8inx 8943 3 cards card NNS cord-010092-uftc8inx 8943 4 were be VBD cord-010092-uftc8inx 8943 5 incubated incubate VBN cord-010092-uftc8inx 8943 6 15 15 CD cord-010092-uftc8inx 8943 7 min min NN cord-010092-uftc8inx 8943 8 , , , cord-010092-uftc8inx 8943 9 37 37 CD cord-010092-uftc8inx 8943 10 ° ° NN cord-010092-uftc8inx 8943 11 C C NNP cord-010092-uftc8inx 8943 12 ( ( -LRB- cord-010092-uftc8inx 8943 13 Coombs Coombs NNP cord-010092-uftc8inx 8943 14 technique technique NN cord-010092-uftc8inx 8943 15 ) ) -RRB- cord-010092-uftc8inx 8943 16 and and CC cord-010092-uftc8inx 8943 17 15 15 CD cord-010092-uftc8inx 8943 18 min min NN cord-010092-uftc8inx 8943 19 , , , cord-010092-uftc8inx 8943 20 18 18 CD cord-010092-uftc8inx 8943 21 - - SYM cord-010092-uftc8inx 8943 22 25 25 CD cord-010092-uftc8inx 8943 23 ° ° NN cord-010092-uftc8inx 8943 24 C c NN cord-010092-uftc8inx 8943 25 ( ( -LRB- cord-010092-uftc8inx 8943 26 saline saline NN cord-010092-uftc8inx 8943 27 technique technique NN cord-010092-uftc8inx 8943 28 ) ) -RRB- cord-010092-uftc8inx 8943 29 , , , cord-010092-uftc8inx 8943 30 centrifuged centrifuge VBN cord-010092-uftc8inx 8943 31 in in IN cord-010092-uftc8inx 8943 32 DG DG NNP cord-010092-uftc8inx 8943 33 Spin Spin NNP cord-010092-uftc8inx 8943 34 and and CC cord-010092-uftc8inx 8943 35 the the DT cord-010092-uftc8inx 8943 36 results result NNS cord-010092-uftc8inx 8943 37 read read VBD cord-010092-uftc8inx 8943 38 . . . cord-010092-uftc8inx 8944 1 Agglutination agglutination NN cord-010092-uftc8inx 8944 2 intensity intensity NN cord-010092-uftc8inx 8944 3 was be VBD cord-010092-uftc8inx 8944 4 graded grade VBN cord-010092-uftc8inx 8944 5 visually visually RB cord-010092-uftc8inx 8944 6 according accord VBG cord-010092-uftc8inx 8944 7 to to IN cord-010092-uftc8inx 8944 8 the the DT cord-010092-uftc8inx 8944 9 instructions instruction NNS cord-010092-uftc8inx 8944 10 for for IN cord-010092-uftc8inx 8944 11 use use NN cord-010092-uftc8inx 8944 12 of of IN cord-010092-uftc8inx 8944 13 DG DG NNP cord-010092-uftc8inx 8944 14 Gel Gel NNP cord-010092-uftc8inx 8944 15 cards card NNS cord-010092-uftc8inx 8944 16 . . . cord-010092-uftc8inx 8945 1 The the DT cord-010092-uftc8inx 8945 2 reciprocal reciprocal NN cord-010092-uftc8inx 8945 3 of of IN cord-010092-uftc8inx 8945 4 the the DT cord-010092-uftc8inx 8945 5 highest high JJS cord-010092-uftc8inx 8945 6 plasma plasma NN cord-010092-uftc8inx 8945 7 dilution dilution NN cord-010092-uftc8inx 8945 8 that that WDT cord-010092-uftc8inx 8945 9 gives give VBZ cord-010092-uftc8inx 8945 10 macroscopic macroscopic JJ cord-010092-uftc8inx 8945 11 agglutination agglutination NN cord-010092-uftc8inx 8945 12 was be VBD cord-010092-uftc8inx 8945 13 interpreted interpret VBN cord-010092-uftc8inx 8945 14 as as IN cord-010092-uftc8inx 8945 15 the the DT cord-010092-uftc8inx 8945 16 titer titer NN cord-010092-uftc8inx 8945 17 . . . cord-010092-uftc8inx 8946 1 Results result NNS cord-010092-uftc8inx 8946 2 : : : cord-010092-uftc8inx 8947 1 Titers titer NNS cord-010092-uftc8inx 8947 2 obtained obtain VBD cord-010092-uftc8inx 8947 3 with with IN cord-010092-uftc8inx 8947 4 DG DG NNP cord-010092-uftc8inx 8947 5 Gel Gel NNP cord-010092-uftc8inx 8947 6 Coombs Coombs NNP cord-010092-uftc8inx 8947 7 and and CC cord-010092-uftc8inx 8947 8 Anti Anti NNP cord-010092-uftc8inx 8947 9 - - NNP cord-010092-uftc8inx 8947 10 IgG IgG NNP cord-010092-uftc8inx 8947 11 ( ( -LRB- cord-010092-uftc8inx 8947 12 n n NN cord-010092-uftc8inx 8947 13 = = SYM cord-010092-uftc8inx 8947 14 80 80 CD cord-010092-uftc8inx 8947 15 titrations titration NNS cord-010092-uftc8inx 8947 16 , , , cord-010092-uftc8inx 8947 17 titer titer NN cord-010092-uftc8inx 8947 18 ranged range VBD cord-010092-uftc8inx 8947 19 0 0 CD cord-010092-uftc8inx 8947 20 - - HYPH cord-010092-uftc8inx 8947 21 256 256 CD cord-010092-uftc8inx 8947 22 ) ) -RRB- cord-010092-uftc8inx 8948 1 were be VBD cord-010092-uftc8inx 8948 2 compared compare VBN cord-010092-uftc8inx 8948 3 for for IN cord-010092-uftc8inx 8948 4 each each DT cord-010092-uftc8inx 8948 5 sample sample NN cord-010092-uftc8inx 8948 6 with with IN cord-010092-uftc8inx 8948 7 unexpected unexpected JJ cord-010092-uftc8inx 8948 8 antibodies antibody NNS cord-010092-uftc8inx 8948 9 . . . cord-010092-uftc8inx 8949 1 No no DT cord-010092-uftc8inx 8949 2 differences difference NNS cord-010092-uftc8inx 8949 3 were be VBD cord-010092-uftc8inx 8949 4 found find VBN cord-010092-uftc8inx 8949 5 between between IN cord-010092-uftc8inx 8949 6 gel gel NN cord-010092-uftc8inx 8949 7 cards card NNS cord-010092-uftc8inx 8949 8 types type NNS cord-010092-uftc8inx 8949 9 ( ( -LRB- cord-010092-uftc8inx 8949 10 differences difference NNS cord-010092-uftc8inx 8949 11 were be VBD cord-010092-uftc8inx 8949 12 ≤ ≤ NNP cord-010092-uftc8inx 8949 13 0.5 0.5 CD cord-010092-uftc8inx 8949 14 titer titer NN cord-010092-uftc8inx 8949 15 in in IN cord-010092-uftc8inx 8949 16 the the DT cord-010092-uftc8inx 8949 17 98 98 CD cord-010092-uftc8inx 8949 18 % % NN cord-010092-uftc8inx 8949 19 of of IN cord-010092-uftc8inx 8949 20 the the DT cord-010092-uftc8inx 8949 21 cases case NNS cord-010092-uftc8inx 8949 22 ) ) -RRB- cord-010092-uftc8inx 8949 23 . . . cord-010092-uftc8inx 8950 1 Differences difference NNS cord-010092-uftc8inx 8950 2 between between IN cord-010092-uftc8inx 8950 3 DG DG NNP cord-010092-uftc8inx 8950 4 Gel Gel NNP cord-010092-uftc8inx 8950 5 Coombs Coombs NNP cord-010092-uftc8inx 8950 6 and and CC cord-010092-uftc8inx 8950 7 Neutral Neutral NNP cord-010092-uftc8inx 8950 8 ( ( -LRB- cord-010092-uftc8inx 8950 9 saline saline NN cord-010092-uftc8inx 8950 10 technique technique NN cord-010092-uftc8inx 8950 11 ) ) -RRB- cord-010092-uftc8inx 8950 12 ( ( -LRB- cord-010092-uftc8inx 8950 13 n n NN cord-010092-uftc8inx 8950 14 = = SYM cord-010092-uftc8inx 8950 15 80 80 CD cord-010092-uftc8inx 8950 16 titrations titration NNS cord-010092-uftc8inx 8950 17 , , , cord-010092-uftc8inx 8950 18 titer titer NN cord-010092-uftc8inx 8950 19 ranged range VBD cord-010092-uftc8inx 8950 20 2 2 CD cord-010092-uftc8inx 8950 21 - - SYM cord-010092-uftc8inx 8950 22 512 512 CD cord-010092-uftc8inx 8950 23 ) ) -RRB- cord-010092-uftc8inx 8950 24 were be VBD cord-010092-uftc8inx 8950 25 observed observe VBN cord-010092-uftc8inx 8950 26 when when WRB cord-010092-uftc8inx 8950 27 anti anti JJ cord-010092-uftc8inx 8950 28 - - JJ cord-010092-uftc8inx 8950 29 A a JJ cord-010092-uftc8inx 8950 30 and and CC cord-010092-uftc8inx 8950 31 -B -B NFP cord-010092-uftc8inx 8950 32 antibodies antibody NNS cord-010092-uftc8inx 8950 33 were be VBD cord-010092-uftc8inx 8950 34 titrated titrate VBN cord-010092-uftc8inx 8950 35 using use VBG cord-010092-uftc8inx 8950 36 the the DT cord-010092-uftc8inx 8950 37 same same JJ cord-010092-uftc8inx 8950 38 sample sample NN cord-010092-uftc8inx 8950 39 . . . cord-010092-uftc8inx 8951 1 The the DT cord-010092-uftc8inx 8951 2 titer titer NN cord-010092-uftc8inx 8951 3 was be VBD cord-010092-uftc8inx 8951 4 similar similar JJ cord-010092-uftc8inx 8951 5 or or CC cord-010092-uftc8inx 8951 6 higher high JJR cord-010092-uftc8inx 8951 7 in in IN cord-010092-uftc8inx 8951 8 Coombs Coombs NNP cord-010092-uftc8inx 8951 9 in in IN cord-010092-uftc8inx 8951 10 comparison comparison NN cord-010092-uftc8inx 8951 11 to to IN cord-010092-uftc8inx 8951 12 the the DT cord-010092-uftc8inx 8951 13 saline saline NN cord-010092-uftc8inx 8951 14 technique technique NN cord-010092-uftc8inx 8951 15 . . . cord-010092-uftc8inx 8952 1 Coombs Coombs NNP cord-010092-uftc8inx 8952 2 titers titer NNS cord-010092-uftc8inx 8952 3 may may MD cord-010092-uftc8inx 8952 4 be be VB cord-010092-uftc8inx 8952 5 a a DT cord-010092-uftc8inx 8952 6 mix mix NN cord-010092-uftc8inx 8952 7 of of IN cord-010092-uftc8inx 8952 8 IgM IgM NNP cord-010092-uftc8inx 8952 9 antibodies antibody NNS cord-010092-uftc8inx 8952 10 reacting react VBG cord-010092-uftc8inx 8952 11 at at IN cord-010092-uftc8inx 8952 12 37 37 CD cord-010092-uftc8inx 8952 13 ° ° NN cord-010092-uftc8inx 8952 14 C c NN cord-010092-uftc8inx 8952 15 and and CC cord-010092-uftc8inx 8952 16 IgG IgG NNP cord-010092-uftc8inx 8952 17 antibodies antibody NNS cord-010092-uftc8inx 8952 18 . . . cord-010092-uftc8inx 8953 1 Differences difference NNS cord-010092-uftc8inx 8953 2 were be VBD cord-010092-uftc8inx 8953 3 > > NNS cord-010092-uftc8inx 8953 4 1 1 CD cord-010092-uftc8inx 8953 5 titer titer NN cord-010092-uftc8inx 8953 6 in in IN cord-010092-uftc8inx 8953 7 35 35 CD cord-010092-uftc8inx 8953 8 % % NN cord-010092-uftc8inx 8953 9 of of IN cord-010092-uftc8inx 8953 10 the the DT cord-010092-uftc8inx 8953 11 comparisons comparison NNS cord-010092-uftc8inx 8953 12 and and CC cord-010092-uftc8inx 8953 13 ≤ ≤ NN cord-010092-uftc8inx 8953 14 1 1 CD cord-010092-uftc8inx 8953 15 titer titer NN cord-010092-uftc8inx 8953 16 in in IN cord-010092-uftc8inx 8953 17 the the DT cord-010092-uftc8inx 8953 18 rest rest NN cord-010092-uftc8inx 8953 19 of of IN cord-010092-uftc8inx 8953 20 the the DT cord-010092-uftc8inx 8953 21 cases case NNS cord-010092-uftc8inx 8953 22 ( ( -LRB- cord-010092-uftc8inx 8953 23 65 65 CD cord-010092-uftc8inx 8953 24 % % NN cord-010092-uftc8inx 8953 25 ) ) -RRB- cord-010092-uftc8inx 8953 26 . . . cord-010092-uftc8inx 8954 1 Comparing compare VBG cord-010092-uftc8inx 8954 2 sample sample NN cord-010092-uftc8inx 8954 3 volumes volume NNS cord-010092-uftc8inx 8954 4 of of IN cord-010092-uftc8inx 8954 5 25 25 CD cord-010092-uftc8inx 8954 6 lL lL NNS cord-010092-uftc8inx 8954 7 and and CC cord-010092-uftc8inx 8954 8 50 50 CD cord-010092-uftc8inx 8954 9 lL lL NNS cord-010092-uftc8inx 8954 10 in in IN cord-010092-uftc8inx 8954 11 all all DT cord-010092-uftc8inx 8954 12 cards card NNS cord-010092-uftc8inx 8954 13 ( ( -LRB- cord-010092-uftc8inx 8954 14 n n NN cord-010092-uftc8inx 8954 15 = = SYM cord-010092-uftc8inx 8954 16 160 160 CD cord-010092-uftc8inx 8954 17 titrations titration NNS cord-010092-uftc8inx 8954 18 ) ) -RRB- cord-010092-uftc8inx 8954 19 , , , cord-010092-uftc8inx 8954 20 higher high JJR cord-010092-uftc8inx 8954 21 titers titer NNS cord-010092-uftc8inx 8954 22 were be VBD cord-010092-uftc8inx 8954 23 observed observe VBN cord-010092-uftc8inx 8954 24 using use VBG cord-010092-uftc8inx 8954 25 50 50 CD cord-010092-uftc8inx 8954 26 lL lL NNPS cord-010092-uftc8inx 8954 27 , , , cord-010092-uftc8inx 8954 28 as as IN cord-010092-uftc8inx 8954 29 expected expect VBN cord-010092-uftc8inx 8954 30 . . . cord-010092-uftc8inx 8955 1 Differences difference NNS cord-010092-uftc8inx 8955 2 were be VBD cord-010092-uftc8inx 8955 3 1 1 CD cord-010092-uftc8inx 8955 4 titer titer NN cord-010092-uftc8inx 8955 5 in in IN cord-010092-uftc8inx 8955 6 the the DT cord-010092-uftc8inx 8955 7 51 51 CD cord-010092-uftc8inx 8955 8 % % NN cord-010092-uftc8inx 8955 9 of of IN cord-010092-uftc8inx 8955 10 the the DT cord-010092-uftc8inx 8955 11 comparisons comparison NNS cord-010092-uftc8inx 8955 12 , , , cord-010092-uftc8inx 8955 13 < < XX cord-010092-uftc8inx 8955 14 1 1 CD cord-010092-uftc8inx 8955 15 titer titer NN cord-010092-uftc8inx 8955 16 in in IN cord-010092-uftc8inx 8955 17 44 44 CD cord-010092-uftc8inx 8955 18 % % NN cord-010092-uftc8inx 8955 19 and and CC cord-010092-uftc8inx 8955 20 > > NN cord-010092-uftc8inx 8955 21 1 1 CD cord-010092-uftc8inx 8955 22 titer titer NN cord-010092-uftc8inx 8955 23 in in IN cord-010092-uftc8inx 8955 24 the the DT cord-010092-uftc8inx 8955 25 5 5 CD cord-010092-uftc8inx 8955 26 % % NN cord-010092-uftc8inx 8955 27 of of IN cord-010092-uftc8inx 8955 28 the the DT cord-010092-uftc8inx 8955 29 cases case NNS cord-010092-uftc8inx 8955 30 . . . cord-010092-uftc8inx 8956 1 Background background NN cord-010092-uftc8inx 8956 2 : : : cord-010092-uftc8inx 8957 1 Autoimmune autoimmune JJ cord-010092-uftc8inx 8957 2 haemolytic haemolytic JJ cord-010092-uftc8inx 8957 3 anemias anemia NNS cord-010092-uftc8inx 8957 4 ( ( -LRB- cord-010092-uftc8inx 8957 5 AIHA AIHA NNP cord-010092-uftc8inx 8957 6 ) ) -RRB- cord-010092-uftc8inx 8957 7 are be VBP cord-010092-uftc8inx 8957 8 characterized characterize VBN cord-010092-uftc8inx 8957 9 by by IN cord-010092-uftc8inx 8957 10 production production NN cord-010092-uftc8inx 8957 11 of of IN cord-010092-uftc8inx 8957 12 antibodies antibody NNS cord-010092-uftc8inx 8957 13 directed direct VBN cord-010092-uftc8inx 8957 14 against against IN cord-010092-uftc8inx 8957 15 red red JJ cord-010092-uftc8inx 8957 16 blood blood NN cord-010092-uftc8inx 8957 17 cells cell NNS cord-010092-uftc8inx 8957 18 and and CC cord-010092-uftc8inx 8957 19 destruction destruction NN cord-010092-uftc8inx 8957 20 by by IN cord-010092-uftc8inx 8957 21 the the DT cord-010092-uftc8inx 8957 22 mononuclear mononuclear JJ cord-010092-uftc8inx 8957 23 phagocytic phagocytic JJ cord-010092-uftc8inx 8957 24 system system NN cord-010092-uftc8inx 8957 25 or or CC cord-010092-uftc8inx 8957 26 complement complement VB cord-010092-uftc8inx 8957 27 system system NN cord-010092-uftc8inx 8957 28 . . . cord-010092-uftc8inx 8958 1 AIHA AIHA NNP cord-010092-uftc8inx 8958 2 observed observe VBD cord-010092-uftc8inx 8958 3 in in IN cord-010092-uftc8inx 8958 4 paediatrics paediatric NNS cord-010092-uftc8inx 8958 5 is be VBZ cord-010092-uftc8inx 8958 6 usually usually RB cord-010092-uftc8inx 8958 7 self self NN cord-010092-uftc8inx 8958 8 - - HYPH cord-010092-uftc8inx 8958 9 limiting limit VBG cord-010092-uftc8inx 8958 10 and and CC cord-010092-uftc8inx 8958 11 often often RB cord-010092-uftc8inx 8958 12 precipitated precipitate VBN cord-010092-uftc8inx 8958 13 by by IN cord-010092-uftc8inx 8958 14 viral viral JJ cord-010092-uftc8inx 8958 15 infections infection NNS cord-010092-uftc8inx 8958 16 . . . cord-010092-uftc8inx 8959 1 In in IN cord-010092-uftc8inx 8959 2 some some DT cord-010092-uftc8inx 8959 3 , , , cord-010092-uftc8inx 8959 4 the the DT cord-010092-uftc8inx 8959 5 condition condition NN cord-010092-uftc8inx 8959 6 is be VBZ cord-010092-uftc8inx 8959 7 secondary secondary JJ cord-010092-uftc8inx 8959 8 to to IN cord-010092-uftc8inx 8959 9 autoimmune autoimmune JJ cord-010092-uftc8inx 8959 10 diseases disease NNS cord-010092-uftc8inx 8959 11 , , , cord-010092-uftc8inx 8959 12 drugs drug NNS cord-010092-uftc8inx 8959 13 , , , cord-010092-uftc8inx 8959 14 infections infection NNS cord-010092-uftc8inx 8959 15 or or CC cord-010092-uftc8inx 8959 16 underlying underlie VBG cord-010092-uftc8inx 8959 17 primary primary JJ cord-010092-uftc8inx 8959 18 immune immune JJ cord-010092-uftc8inx 8959 19 deficiencies deficiency NNS cord-010092-uftc8inx 8959 20 . . . cord-010092-uftc8inx 8960 1 Appropriate appropriate JJ cord-010092-uftc8inx 8960 2 immuno immuno JJ cord-010092-uftc8inx 8960 3 hematological hematological JJ cord-010092-uftc8inx 8960 4 evaluation evaluation NN cord-010092-uftc8inx 8960 5 to to TO cord-010092-uftc8inx 8960 6 characterise characterise VB cord-010092-uftc8inx 8960 7 the the DT cord-010092-uftc8inx 8960 8 underlying underlie VBG cord-010092-uftc8inx 8960 9 autoantibody autoantibody NN cord-010092-uftc8inx 8960 10 can can MD cord-010092-uftc8inx 8960 11 help help VB cord-010092-uftc8inx 8960 12 identify identify VB cord-010092-uftc8inx 8960 13 the the DT cord-010092-uftc8inx 8960 14 type type NN cord-010092-uftc8inx 8960 15 of of IN cord-010092-uftc8inx 8960 16 AIHA AIHA NNP cord-010092-uftc8inx 8960 17 to to TO cord-010092-uftc8inx 8960 18 aid aid VB cord-010092-uftc8inx 8960 19 in in IN cord-010092-uftc8inx 8960 20 diagnosis diagnosis NN cord-010092-uftc8inx 8960 21 & & CC cord-010092-uftc8inx 8960 22 treatment treatment NN cord-010092-uftc8inx 8960 23 of of IN cord-010092-uftc8inx 8960 24 these these DT cord-010092-uftc8inx 8960 25 cases case NNS cord-010092-uftc8inx 8960 26 . . . cord-010092-uftc8inx 8961 1 Aims aim VBZ cord-010092-uftc8inx 8961 2 : : : cord-010092-uftc8inx 8962 1 Retrospective retrospective JJ cord-010092-uftc8inx 8962 2 analysis analysis NN cord-010092-uftc8inx 8962 3 of of IN cord-010092-uftc8inx 8962 4 immune immune JJ cord-010092-uftc8inx 8962 5 - - HYPH cord-010092-uftc8inx 8962 6 hematological hematological JJ cord-010092-uftc8inx 8962 7 evaluation evaluation NN cord-010092-uftc8inx 8962 8 , , , cord-010092-uftc8inx 8962 9 treatment treatment NN cord-010092-uftc8inx 8962 10 and and CC cord-010092-uftc8inx 8962 11 outcome outcome NN cord-010092-uftc8inx 8962 12 of of IN cord-010092-uftc8inx 8962 13 AIHA AIHA NNP cord-010092-uftc8inx 8962 14 in in IN cord-010092-uftc8inx 8962 15 paediatrics paediatric NNS cord-010092-uftc8inx 8962 16 . . . cord-010092-uftc8inx 8963 1 Methods method NNS cord-010092-uftc8inx 8963 2 : : : cord-010092-uftc8inx 8964 1 Patients patient NNS cord-010092-uftc8inx 8964 2 aged aged JJ cord-010092-uftc8inx 8964 3 0 0 CD cord-010092-uftc8inx 8964 4 - - SYM cord-010092-uftc8inx 8964 5 18 18 CD cord-010092-uftc8inx 8964 6 years year NNS cord-010092-uftc8inx 8964 7 , , , cord-010092-uftc8inx 8964 8 diagnosed diagnose VBN cord-010092-uftc8inx 8964 9 with with IN cord-010092-uftc8inx 8964 10 AIHA AIHA NNP cord-010092-uftc8inx 8964 11 , , , cord-010092-uftc8inx 8964 12 between between IN cord-010092-uftc8inx 8964 13 April April NNP cord-010092-uftc8inx 8964 14 2017-December 2017-december CD cord-010092-uftc8inx 8964 15 2018 2018 CD cord-010092-uftc8inx 8964 16 ( ( -LRB- cord-010092-uftc8inx 8964 17 21 21 CD cord-010092-uftc8inx 8964 18 months month NNS cord-010092-uftc8inx 8964 19 ) ) -RRB- cord-010092-uftc8inx 8964 20 were be VBD cord-010092-uftc8inx 8964 21 included include VBN cord-010092-uftc8inx 8964 22 in in IN cord-010092-uftc8inx 8964 23 this this DT cord-010092-uftc8inx 8964 24 analysis analysis NN cord-010092-uftc8inx 8964 25 . . . cord-010092-uftc8inx 8965 1 AIHA AIHA NNP cord-010092-uftc8inx 8965 2 was be VBD cord-010092-uftc8inx 8965 3 defined define VBN cord-010092-uftc8inx 8965 4 as as IN cord-010092-uftc8inx 8965 5 positive positive JJ cord-010092-uftc8inx 8965 6 direct direct JJ cord-010092-uftc8inx 8965 7 Coombs Coombs NNP cord-010092-uftc8inx 8965 8 ' ' POS cord-010092-uftc8inx 8965 9 test test NN cord-010092-uftc8inx 8965 10 ( ( -LRB- cord-010092-uftc8inx 8965 11 DCT DCT NNP cord-010092-uftc8inx 8965 12 ) ) -RRB- cord-010092-uftc8inx 8965 13 with with IN cord-010092-uftc8inx 8965 14 anemia anemia NN cord-010092-uftc8inx 8965 15 associated associate VBN cord-010092-uftc8inx 8965 16 with with IN cord-010092-uftc8inx 8965 17 corroborative corroborative JJ cord-010092-uftc8inx 8965 18 evidence evidence NN cord-010092-uftc8inx 8965 19 of of IN cord-010092-uftc8inx 8965 20 haemolysis haemolysis NN cord-010092-uftc8inx 8965 21 in in IN cord-010092-uftc8inx 8965 22 the the DT cord-010092-uftc8inx 8965 23 form form NN cord-010092-uftc8inx 8965 24 of of IN cord-010092-uftc8inx 8965 25 raised raise VBN cord-010092-uftc8inx 8965 26 indirect indirect JJ cord-010092-uftc8inx 8965 27 hyperbilirubinemia hyperbilirubinemia NN cord-010092-uftc8inx 8965 28 , , , cord-010092-uftc8inx 8965 29 raised raise VBD cord-010092-uftc8inx 8965 30 LDH LDH NNP cord-010092-uftc8inx 8965 31 , , , cord-010092-uftc8inx 8965 32 raised raise VBD cord-010092-uftc8inx 8965 33 reticulocyte reticulocyte NN cord-010092-uftc8inx 8965 34 counts count NNS cord-010092-uftc8inx 8965 35 or or CC cord-010092-uftc8inx 8965 36 red red JJ cord-010092-uftc8inx 8965 37 cell cell NN cord-010092-uftc8inx 8965 38 agglutination agglutination NN cord-010092-uftc8inx 8965 39 on on IN cord-010092-uftc8inx 8965 40 peripheral peripheral JJ cord-010092-uftc8inx 8965 41 smear smear NN cord-010092-uftc8inx 8965 42 . . . cord-010092-uftc8inx 8966 1 Further further RB cord-010092-uftc8inx 8966 2 monospecific monospecific JJ cord-010092-uftc8inx 8966 3 DCT dct NN cord-010092-uftc8inx 8966 4 and and CC cord-010092-uftc8inx 8966 5 evaluation evaluation NN cord-010092-uftc8inx 8966 6 for for IN cord-010092-uftc8inx 8966 7 the the DT cord-010092-uftc8inx 8966 8 specificity specificity NN cord-010092-uftc8inx 8966 9 of of IN cord-010092-uftc8inx 8966 10 autoantibody autoantibody NN cord-010092-uftc8inx 8966 11 was be VBD cord-010092-uftc8inx 8966 12 done do VBN cord-010092-uftc8inx 8966 13 for for IN cord-010092-uftc8inx 8966 14 all all DT cord-010092-uftc8inx 8966 15 patients patient NNS cord-010092-uftc8inx 8966 16 using use VBG cord-010092-uftc8inx 8966 17 BioRad BioRad NNP cord-010092-uftc8inx 8966 18 gel gel NN cord-010092-uftc8inx 8966 19 cards card NNS cord-010092-uftc8inx 8966 20 and and CC cord-010092-uftc8inx 8966 21 panel panel NN cord-010092-uftc8inx 8966 22 cells cell NNS cord-010092-uftc8inx 8966 23 . . . cord-010092-uftc8inx 8967 1 Steroids steroid NNS cord-010092-uftc8inx 8967 2 were be VBD cord-010092-uftc8inx 8967 3 given give VBN cord-010092-uftc8inx 8967 4 as as IN cord-010092-uftc8inx 8967 5 first first JJ cord-010092-uftc8inx 8967 6 line line NN cord-010092-uftc8inx 8967 7 in in IN cord-010092-uftc8inx 8967 8 all all DT cord-010092-uftc8inx 8967 9 ; ; : cord-010092-uftc8inx 8967 10 second second JJ cord-010092-uftc8inx 8967 11 line line NN cord-010092-uftc8inx 8967 12 agents agent NNS cord-010092-uftc8inx 8967 13 included include VBD cord-010092-uftc8inx 8967 14 cyclosporine cyclosporine NN cord-010092-uftc8inx 8967 15 and and CC cord-010092-uftc8inx 8967 16 rituximab rituximab NN cord-010092-uftc8inx 8967 17 . . . cord-010092-uftc8inx 8968 1 Red red JJ cord-010092-uftc8inx 8968 2 cell cell NN cord-010092-uftc8inx 8968 3 transfusion transfusion NN cord-010092-uftc8inx 8968 4 was be VBD cord-010092-uftc8inx 8968 5 given give VBN cord-010092-uftc8inx 8968 6 in in IN cord-010092-uftc8inx 8968 7 those those DT cord-010092-uftc8inx 8968 8 with with IN cord-010092-uftc8inx 8968 9 severe severe JJ cord-010092-uftc8inx 8968 10 anemia anemia NN cord-010092-uftc8inx 8968 11 with with IN cord-010092-uftc8inx 8968 12 cardiac cardiac JJ cord-010092-uftc8inx 8968 13 decompensation decompensation NN cord-010092-uftc8inx 8968 14 . . . cord-010092-uftc8inx 8969 1 Results result NNS cord-010092-uftc8inx 8969 2 : : : cord-010092-uftc8inx 8969 3 10 10 CD cord-010092-uftc8inx 8969 4 patients patient NNS cord-010092-uftc8inx 8969 5 were be VBD cord-010092-uftc8inx 8969 6 diagnosed diagnose VBN cord-010092-uftc8inx 8969 7 during during IN cord-010092-uftc8inx 8969 8 the the DT cord-010092-uftc8inx 8969 9 study study NN cord-010092-uftc8inx 8969 10 period period NN cord-010092-uftc8inx 8969 11 with with IN cord-010092-uftc8inx 8969 12 autoimmune autoimmune JJ cord-010092-uftc8inx 8969 13 haemolytic haemolytic JJ cord-010092-uftc8inx 8969 14 anemia anemia NN cord-010092-uftc8inx 8969 15 . . . cord-010092-uftc8inx 8970 1 Haemoglobin haemoglobin NN cord-010092-uftc8inx 8970 2 at at IN cord-010092-uftc8inx 8970 3 presentation presentation NN cord-010092-uftc8inx 8970 4 ranged range VBD cord-010092-uftc8inx 8970 5 from from IN cord-010092-uftc8inx 8970 6 2.5 2.5 CD cord-010092-uftc8inx 8970 7 to to TO cord-010092-uftc8inx 8970 8 9 9 CD cord-010092-uftc8inx 8970 9 grams gram NNS cord-010092-uftc8inx 8970 10 / / SYM cord-010092-uftc8inx 8970 11 dl dl NN cord-010092-uftc8inx 8970 12 . . . cord-010092-uftc8inx 8971 1 The the DT cord-010092-uftc8inx 8971 2 initial initial JJ cord-010092-uftc8inx 8971 3 presentation presentation NN cord-010092-uftc8inx 8971 4 was be VBD cord-010092-uftc8inx 8971 5 severe severe JJ cord-010092-uftc8inx 8971 6 anemia anemia NN cord-010092-uftc8inx 8971 7 in in IN cord-010092-uftc8inx 8971 8 7 7 CD cord-010092-uftc8inx 8971 9 children child NNS cord-010092-uftc8inx 8971 10 and and CC cord-010092-uftc8inx 8971 11 mild mild JJ cord-010092-uftc8inx 8971 12 - - HYPH cord-010092-uftc8inx 8971 13 moderate moderate JJ cord-010092-uftc8inx 8971 14 anemia anemia NN cord-010092-uftc8inx 8971 15 with with IN cord-010092-uftc8inx 8971 16 thrombocytopenia thrombocytopenia NN cord-010092-uftc8inx 8971 17 ( ( -LRB- cord-010092-uftc8inx 8971 18 Evan Evan NNP cord-010092-uftc8inx 8971 19 's 's POS cord-010092-uftc8inx 8971 20 syndrome syndrome NN cord-010092-uftc8inx 8971 21 ) ) -RRB- cord-010092-uftc8inx 8971 22 in in IN cord-010092-uftc8inx 8971 23 3 3 CD cord-010092-uftc8inx 8971 24 . . . cord-010092-uftc8inx 8972 1 The the DT cord-010092-uftc8inx 8972 2 trigger trigger NN cord-010092-uftc8inx 8972 3 for for IN cord-010092-uftc8inx 8972 4 haemolysis haemolysis NN cord-010092-uftc8inx 8972 5 was be VBD cord-010092-uftc8inx 8972 6 infection infection NN cord-010092-uftc8inx 8972 7 in in IN cord-010092-uftc8inx 8972 8 4 4 CD cord-010092-uftc8inx 8972 9 children child NNS cord-010092-uftc8inx 8972 10 . . . cord-010092-uftc8inx 8973 1 Rheumatological rheumatological JJ cord-010092-uftc8inx 8973 2 evaluation evaluation NN cord-010092-uftc8inx 8973 3 was be VBD cord-010092-uftc8inx 8973 4 performed perform VBN cord-010092-uftc8inx 8973 5 for for IN cord-010092-uftc8inx 8973 6 5 5 CD cord-010092-uftc8inx 8973 7 children child NNS cord-010092-uftc8inx 8973 8 out out IN cord-010092-uftc8inx 8973 9 of of IN cord-010092-uftc8inx 8973 10 whom whom WP cord-010092-uftc8inx 8973 11 2 2 CD cord-010092-uftc8inx 8973 12 were be VBD cord-010092-uftc8inx 8973 13 diagnosed diagnose VBN cord-010092-uftc8inx 8973 14 as as IN cord-010092-uftc8inx 8973 15 evolving evolve VBG cord-010092-uftc8inx 8973 16 lupus lupus NN cord-010092-uftc8inx 8973 17 . . . cord-010092-uftc8inx 8974 1 Primary primary JJ cord-010092-uftc8inx 8974 2 immune immune JJ cord-010092-uftc8inx 8974 3 deficiency deficiency NN cord-010092-uftc8inx 8974 4 evaluation evaluation NN cord-010092-uftc8inx 8974 5 was be VBD cord-010092-uftc8inx 8974 6 advised advise VBN cord-010092-uftc8inx 8974 7 for for IN cord-010092-uftc8inx 8974 8 4 4 CD cord-010092-uftc8inx 8974 9 and and CC cord-010092-uftc8inx 8974 10 one one CD cord-010092-uftc8inx 8974 11 child child NN cord-010092-uftc8inx 8974 12 was be VBD cord-010092-uftc8inx 8974 13 diagnosed diagnose VBN cord-010092-uftc8inx 8974 14 as as IN cord-010092-uftc8inx 8974 15 suffering suffer VBG cord-010092-uftc8inx 8974 16 from from IN cord-010092-uftc8inx 8974 17 combined combine VBN cord-010092-uftc8inx 8974 18 immunodeficiency immunodeficiency NN cord-010092-uftc8inx 8974 19 . . . cord-010092-uftc8inx 8975 1 DAT DAT NNP cord-010092-uftc8inx 8975 2 was be VBD cord-010092-uftc8inx 8975 3 positive positive JJ cord-010092-uftc8inx 8975 4 in in IN cord-010092-uftc8inx 8975 5 9 9 CD cord-010092-uftc8inx 8975 6 out out IN cord-010092-uftc8inx 8975 7 of of IN cord-010092-uftc8inx 8975 8 10 10 CD cord-010092-uftc8inx 8975 9 AIHA AIHA NNP cord-010092-uftc8inx 8975 10 patients patient NNS cord-010092-uftc8inx 8975 11 as as IN cord-010092-uftc8inx 8975 12 one one CD cord-010092-uftc8inx 8975 13 of of IN cord-010092-uftc8inx 8975 14 the the DT cord-010092-uftc8inx 8975 15 infant infant NN cord-010092-uftc8inx 8975 16 had have VBD cord-010092-uftc8inx 8975 17 DAT DAT NNP cord-010092-uftc8inx 8975 18 negative negative JJ cord-010092-uftc8inx 8975 19 IgA IgA NNP cord-010092-uftc8inx 8975 20 mediated mediate VBN cord-010092-uftc8inx 8975 21 AIHA AIHA NNP cord-010092-uftc8inx 8975 22 secondary secondary JJ cord-010092-uftc8inx 8975 23 to to IN cord-010092-uftc8inx 8975 24 viral viral JJ cord-010092-uftc8inx 8975 25 infection infection NN cord-010092-uftc8inx 8975 26 . . . cord-010092-uftc8inx 8976 1 Two two CD cord-010092-uftc8inx 8976 2 out out IN cord-010092-uftc8inx 8976 3 of of IN cord-010092-uftc8inx 8976 4 9 9 CD cord-010092-uftc8inx 8976 5 DAT DAT NNP cord-010092-uftc8inx 8976 6 positive positive JJ cord-010092-uftc8inx 8976 7 cases case NNS cord-010092-uftc8inx 8976 8 had have VBD cord-010092-uftc8inx 8976 9 IgG IgG NNP cord-010092-uftc8inx 8976 10 & & CC cord-010092-uftc8inx 8976 11 C3d C3d NNP cord-010092-uftc8inx 8976 12 positivity positivity NN cord-010092-uftc8inx 8976 13 on on IN cord-010092-uftc8inx 8976 14 monoclonal monoclonal JJ cord-010092-uftc8inx 8976 15 DAT DAT NNP cord-010092-uftc8inx 8976 16 testing testing NN cord-010092-uftc8inx 8976 17 whereas whereas IN cord-010092-uftc8inx 8976 18 rest rest NN cord-010092-uftc8inx 8976 19 7 7 CD cord-010092-uftc8inx 8976 20 had have VBD cord-010092-uftc8inx 8976 21 only only RB cord-010092-uftc8inx 8976 22 IgG igg NN cord-010092-uftc8inx 8976 23 coating coat VBG cord-010092-uftc8inx 8976 24 the the DT cord-010092-uftc8inx 8976 25 red red JJ cord-010092-uftc8inx 8976 26 cells cell NNS cord-010092-uftc8inx 8976 27 . . . cord-010092-uftc8inx 8977 1 DAT DAT NNP cord-010092-uftc8inx 8977 2 titration titration NN cord-010092-uftc8inx 8977 3 was be VBD cord-010092-uftc8inx 8977 4 more more JJR cord-010092-uftc8inx 8977 5 than than IN cord-010092-uftc8inx 8977 6 1:300 1:300 CD cord-010092-uftc8inx 8977 7 in in IN cord-010092-uftc8inx 8977 8 4 4 CD cord-010092-uftc8inx 8977 9 patients patient NNS cord-010092-uftc8inx 8977 10 ; ; : cord-010092-uftc8inx 8977 11 where where WRB cord-010092-uftc8inx 8977 12 only only RB cord-010092-uftc8inx 8977 13 1 1 CD cord-010092-uftc8inx 8977 14 of of IN cord-010092-uftc8inx 8977 15 these these DT cord-010092-uftc8inx 8977 16 4 4 CD cord-010092-uftc8inx 8977 17 patients patient NNS cord-010092-uftc8inx 8977 18 had have VBD cord-010092-uftc8inx 8977 19 both both DT cord-010092-uftc8inx 8977 20 IgG1 igg1 NN cord-010092-uftc8inx 8977 21 and and CC cord-010092-uftc8inx 8977 22 IgG3 IgG3 NNP cord-010092-uftc8inx 8977 23 coating coating NN cord-010092-uftc8inx 8977 24 and and CC cord-010092-uftc8inx 8977 25 rest rest NN cord-010092-uftc8inx 8977 26 3 3 CD cord-010092-uftc8inx 8977 27 had have VBD cord-010092-uftc8inx 8977 28 only only RB cord-010092-uftc8inx 8977 29 IgG1 igg1 NN cord-010092-uftc8inx 8977 30 . . . cord-010092-uftc8inx 8978 1 Alloantibody alloantibody NN cord-010092-uftc8inx 8978 2 screen screen NN cord-010092-uftc8inx 8978 3 was be VBD cord-010092-uftc8inx 8978 4 negative negative JJ cord-010092-uftc8inx 8978 5 in in IN cord-010092-uftc8inx 8978 6 all all DT cord-010092-uftc8inx 8978 7 . . . cord-010092-uftc8inx 8979 1 Specificity specificity NN cord-010092-uftc8inx 8979 2 of of IN cord-010092-uftc8inx 8979 3 autoantibody autoantibody NN cord-010092-uftc8inx 8979 4 was be VBD cord-010092-uftc8inx 8979 5 found find VBN cord-010092-uftc8inx 8979 6 only only RB cord-010092-uftc8inx 8979 7 in in IN cord-010092-uftc8inx 8979 8 one one CD cord-010092-uftc8inx 8979 9 case case NN cord-010092-uftc8inx 8979 10 , , , cord-010092-uftc8inx 8979 11 which which WDT cord-010092-uftc8inx 8979 12 was be VBD cord-010092-uftc8inx 8979 13 against against IN cord-010092-uftc8inx 8979 14 Rh Rh NNP cord-010092-uftc8inx 8979 15 blood blood NN cord-010092-uftc8inx 8979 16 group group NN cord-010092-uftc8inx 8979 17 antigen antigen NN cord-010092-uftc8inx 8979 18 ( ( -LRB- cord-010092-uftc8inx 8979 19 anti anti NNP cord-010092-uftc8inx 8979 20 E E NNP cord-010092-uftc8inx 8979 21 ) ) -RRB- cord-010092-uftc8inx 8979 22 . . . cord-010092-uftc8inx 8980 1 All all DT cord-010092-uftc8inx 8980 2 patients patient NNS cord-010092-uftc8inx 8980 3 received receive VBD cord-010092-uftc8inx 8980 4 prednisolone prednisolone NN cord-010092-uftc8inx 8980 5 as as IN cord-010092-uftc8inx 8980 6 the the DT cord-010092-uftc8inx 8980 7 primary primary JJ cord-010092-uftc8inx 8980 8 treatment treatment NN cord-010092-uftc8inx 8980 9 . . . cord-010092-uftc8inx 8981 1 Three three CD cord-010092-uftc8inx 8981 2 children child NNS cord-010092-uftc8inx 8981 3 attained attain VBD cord-010092-uftc8inx 8981 4 remission remission NN cord-010092-uftc8inx 8981 5 following follow VBG cord-010092-uftc8inx 8981 6 a a DT cord-010092-uftc8inx 8981 7 4 4 CD cord-010092-uftc8inx 8981 8 - - SYM cord-010092-uftc8inx 8981 9 6 6 CD cord-010092-uftc8inx 8981 10 weeks week NNS cord-010092-uftc8inx 8981 11 of of IN cord-010092-uftc8inx 8981 12 steroids steroid NNS cord-010092-uftc8inx 8981 13 . . . cord-010092-uftc8inx 8982 1 In in IN cord-010092-uftc8inx 8982 2 those those DT cord-010092-uftc8inx 8982 3 who who WP cord-010092-uftc8inx 8982 4 were be VBD cord-010092-uftc8inx 8982 5 steroid steroid JJ cord-010092-uftc8inx 8982 6 dependent dependent JJ cord-010092-uftc8inx 8982 7 , , , cord-010092-uftc8inx 8982 8 cyclosporine cyclosporine NN cord-010092-uftc8inx 8982 9 was be VBD cord-010092-uftc8inx 8982 10 used use VBN cord-010092-uftc8inx 8982 11 as as IN cord-010092-uftc8inx 8982 12 the the DT cord-010092-uftc8inx 8982 13 second second JJ cord-010092-uftc8inx 8982 14 line line NN cord-010092-uftc8inx 8982 15 agent agent NN cord-010092-uftc8inx 8982 16 in in IN cord-010092-uftc8inx 8982 17 2 2 CD cord-010092-uftc8inx 8982 18 and and CC cord-010092-uftc8inx 8982 19 Rituximab Rituximab NNPS cord-010092-uftc8inx 8982 20 was be VBD cord-010092-uftc8inx 8982 21 used use VBN cord-010092-uftc8inx 8982 22 in in IN cord-010092-uftc8inx 8982 23 3 3 CD cord-010092-uftc8inx 8982 24 . . . cord-010092-uftc8inx 8983 1 Out out IN cord-010092-uftc8inx 8983 2 of of IN cord-010092-uftc8inx 8983 3 these these DT cord-010092-uftc8inx 8983 4 children child NNS cord-010092-uftc8inx 8983 5 5 5 CD cord-010092-uftc8inx 8983 6 children child NNS cord-010092-uftc8inx 8983 7 are be VBP cord-010092-uftc8inx 8983 8 in in IN cord-010092-uftc8inx 8983 9 sustained sustained JJ cord-010092-uftc8inx 8983 10 remission remission NN cord-010092-uftc8inx 8983 11 and and CC cord-010092-uftc8inx 8983 12 off off IN cord-010092-uftc8inx 8983 13 any any DT cord-010092-uftc8inx 8983 14 medication medication NN cord-010092-uftc8inx 8983 15 , , , cord-010092-uftc8inx 8983 16 whereas whereas IN cord-010092-uftc8inx 8983 17 the the DT cord-010092-uftc8inx 8983 18 rest rest NN cord-010092-uftc8inx 8983 19 are be VBP cord-010092-uftc8inx 8983 20 on on IN cord-010092-uftc8inx 8983 21 low low JJ cord-010092-uftc8inx 8983 22 dose dose NN cord-010092-uftc8inx 8983 23 steroids steroid NNS cord-010092-uftc8inx 8983 24 with with IN cord-010092-uftc8inx 8983 25 cyclosporine cyclosporine NN cord-010092-uftc8inx 8983 26 . . . cord-010092-uftc8inx 8984 1 Summary Summary NNP cord-010092-uftc8inx 8984 2 / / SYM cord-010092-uftc8inx 8984 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 8984 4 : : : cord-010092-uftc8inx 8985 1 AIHA AIHA NNP cord-010092-uftc8inx 8985 2 is be VBZ cord-010092-uftc8inx 8985 3 not not RB cord-010092-uftc8inx 8985 4 an an DT cord-010092-uftc8inx 8985 5 uncommon uncommon JJ cord-010092-uftc8inx 8985 6 problem problem NN cord-010092-uftc8inx 8985 7 in in IN cord-010092-uftc8inx 8985 8 children child NNS cord-010092-uftc8inx 8985 9 and and CC cord-010092-uftc8inx 8985 10 can can MD cord-010092-uftc8inx 8985 11 vary vary VB cord-010092-uftc8inx 8985 12 in in IN cord-010092-uftc8inx 8985 13 its -PRON- PRP$ cord-010092-uftc8inx 8985 14 clinical clinical JJ cord-010092-uftc8inx 8985 15 severity severity NN cord-010092-uftc8inx 8985 16 . . . cord-010092-uftc8inx 8986 1 The the DT cord-010092-uftc8inx 8986 2 proper proper JJ cord-010092-uftc8inx 8986 3 diagnosis diagnosis NN cord-010092-uftc8inx 8986 4 and and CC cord-010092-uftc8inx 8986 5 management management NN cord-010092-uftc8inx 8986 6 involves involve VBZ cord-010092-uftc8inx 8986 7 efficient efficient JJ cord-010092-uftc8inx 8986 8 immuno immuno JJ cord-010092-uftc8inx 8986 9 - - HYPH cord-010092-uftc8inx 8986 10 hematological hematological JJ cord-010092-uftc8inx 8986 11 evaluation evaluation NN cord-010092-uftc8inx 8986 12 , , , cord-010092-uftc8inx 8986 13 as as IN cord-010092-uftc8inx 8986 14 detailed detailed JJ cord-010092-uftc8inx 8986 15 characterization characterization NN cord-010092-uftc8inx 8986 16 of of IN cord-010092-uftc8inx 8986 17 the the DT cord-010092-uftc8inx 8986 18 autoantibody autoantibody NN cord-010092-uftc8inx 8986 19 coating coat VBG cord-010092-uftc8inx 8986 20 the the DT cord-010092-uftc8inx 8986 21 red red JJ cord-010092-uftc8inx 8986 22 cell cell NN cord-010092-uftc8inx 8986 23 is be VBZ cord-010092-uftc8inx 8986 24 very very RB cord-010092-uftc8inx 8986 25 important important JJ cord-010092-uftc8inx 8986 26 in in IN cord-010092-uftc8inx 8986 27 guiding guide VBG cord-010092-uftc8inx 8986 28 the the DT cord-010092-uftc8inx 8986 29 clinician clinician NN cord-010092-uftc8inx 8986 30 for for IN cord-010092-uftc8inx 8986 31 management management NN cord-010092-uftc8inx 8986 32 and and CC cord-010092-uftc8inx 8986 33 prognosis prognosis NN cord-010092-uftc8inx 8986 34 . . . cord-010092-uftc8inx 8987 1 Abstract Abstract NNP cord-010092-uftc8inx 8987 2 withdrawn withdraw VBN cord-010092-uftc8inx 8987 3 . . . cord-010092-uftc8inx 8988 1 Background background NN cord-010092-uftc8inx 8988 2 : : : cord-010092-uftc8inx 8989 1 Drug drug NN cord-010092-uftc8inx 8989 2 - - HYPH cord-010092-uftc8inx 8989 3 induced induce VBN cord-010092-uftc8inx 8989 4 immune immune JJ cord-010092-uftc8inx 8989 5 hemolytic hemolytic JJ cord-010092-uftc8inx 8989 6 anemia anemia NN cord-010092-uftc8inx 8989 7 ( ( -LRB- cord-010092-uftc8inx 8989 8 DIIHA DIIHA NNP cord-010092-uftc8inx 8989 9 ) ) -RRB- cord-010092-uftc8inx 8989 10 is be VBZ cord-010092-uftc8inx 8989 11 rare rare JJ cord-010092-uftc8inx 8989 12 and and CC cord-010092-uftc8inx 8989 13 has have VBZ cord-010092-uftc8inx 8989 14 only only RB cord-010092-uftc8inx 8989 15 been be VBN cord-010092-uftc8inx 8989 16 described describe VBN cord-010092-uftc8inx 8989 17 once once RB cord-010092-uftc8inx 8989 18 with with IN cord-010092-uftc8inx 8989 19 dexchlorpheniramine dexchlorpheniramine NN cord-010092-uftc8inx 8989 20 ( ( -LRB- cord-010092-uftc8inx 8989 21 Polaramine Polaramine NNP cord-010092-uftc8inx 8989 22 TM TM NNP cord-010092-uftc8inx 8989 23 ) ) -RRB- cord-010092-uftc8inx 8989 24 , , , cord-010092-uftc8inx 8989 25 an an DT cord-010092-uftc8inx 8989 26 antihistaminic antihistaminic NNP cord-010092-uftc8inx 8989 27 agent agent NN cord-010092-uftc8inx 8989 28 widely widely RB cord-010092-uftc8inx 8989 29 used use VBN cord-010092-uftc8inx 8989 30 in in IN cord-010092-uftc8inx 8989 31 the the DT cord-010092-uftc8inx 8989 32 treatment treatment NN cord-010092-uftc8inx 8989 33 of of IN cord-010092-uftc8inx 8989 34 a a DT cord-010092-uftc8inx 8989 35 variety variety NN cord-010092-uftc8inx 8989 36 of of IN cord-010092-uftc8inx 8989 37 allergic allergic JJ cord-010092-uftc8inx 8989 38 reactions reaction NNS cord-010092-uftc8inx 8989 39 . . . cord-010092-uftc8inx 8990 1 We -PRON- PRP cord-010092-uftc8inx 8990 2 report report VBP cord-010092-uftc8inx 8990 3 a a DT cord-010092-uftc8inx 8990 4 case case NN cord-010092-uftc8inx 8990 5 of of IN cord-010092-uftc8inx 8990 6 DIIHA DIIHA NNP cord-010092-uftc8inx 8990 7 complicated complicate VBN cord-010092-uftc8inx 8990 8 with with IN cord-010092-uftc8inx 8990 9 acute acute JJ cord-010092-uftc8inx 8990 10 renal renal JJ cord-010092-uftc8inx 8990 11 failure failure NN cord-010092-uftc8inx 8990 12 associated associate VBN cord-010092-uftc8inx 8990 13 with with IN cord-010092-uftc8inx 8990 14 antibodies antibody NNS cord-010092-uftc8inx 8990 15 to to TO cord-010092-uftc8inx 8990 16 dexchlorpheniramine dexchlorpheniramine VB cord-010092-uftc8inx 8990 17 . . . cord-010092-uftc8inx 8991 1 A a DT cord-010092-uftc8inx 8991 2 64-year 64-year JJ cord-010092-uftc8inx 8991 3 - - HYPH cord-010092-uftc8inx 8991 4 old old JJ cord-010092-uftc8inx 8991 5 woman woman NN cord-010092-uftc8inx 8991 6 with with IN cord-010092-uftc8inx 8991 7 no no DT cord-010092-uftc8inx 8991 8 history history NN cord-010092-uftc8inx 8991 9 of of IN cord-010092-uftc8inx 8991 10 transfusion transfusion NN cord-010092-uftc8inx 8991 11 , , , cord-010092-uftc8inx 8991 12 was be VBD cord-010092-uftc8inx 8991 13 treated treat VBN cord-010092-uftc8inx 8991 14 semimonthly semimonthly RB cord-010092-uftc8inx 8991 15 with with IN cord-010092-uftc8inx 8991 16 a a DT cord-010092-uftc8inx 8991 17 combination combination NN cord-010092-uftc8inx 8991 18 of of IN cord-010092-uftc8inx 8991 19 chemotherapy chemotherapy NN cord-010092-uftc8inx 8991 20 and and CC cord-010092-uftc8inx 8991 21 targeted target VBN cord-010092-uftc8inx 8991 22 therapy therapy NN cord-010092-uftc8inx 8991 23 for for IN cord-010092-uftc8inx 8991 24 metastatic metastatic JJ cord-010092-uftc8inx 8991 25 colorectal colorectal JJ cord-010092-uftc8inx 8991 26 adenocarcinoma adenocarcinoma NN cord-010092-uftc8inx 8991 27 . . . cord-010092-uftc8inx 8992 1 Her -PRON- PRP$ cord-010092-uftc8inx 8992 2 chemotherapy chemotherapy NN cord-010092-uftc8inx 8992 3 regimen regimen NN cord-010092-uftc8inx 8992 4 consisted consist VBD cord-010092-uftc8inx 8992 5 of of IN cord-010092-uftc8inx 8992 6 oxaliplatin oxaliplatin NNP cord-010092-uftc8inx 8992 7 and and CC cord-010092-uftc8inx 8992 8 5-FU 5-fu CD cord-010092-uftc8inx 8992 9 with with IN cord-010092-uftc8inx 8992 10 leucovorin leucovorin NN cord-010092-uftc8inx 8992 11 rescue rescue NN cord-010092-uftc8inx 8992 12 ( ( -LRB- cord-010092-uftc8inx 8992 13 FOLFOX FOLFOX NNP cord-010092-uftc8inx 8992 14 ) ) -RRB- cord-010092-uftc8inx 8992 15 . . . cord-010092-uftc8inx 8993 1 Panitumumab Panitumumab NNP cord-010092-uftc8inx 8993 2 ( ( -LRB- cord-010092-uftc8inx 8993 3 monoclonal monoclonal JJ cord-010092-uftc8inx 8993 4 antibody antibody NN cord-010092-uftc8inx 8993 5 anti anti JJ cord-010092-uftc8inx 8993 6 - - JJ cord-010092-uftc8inx 8993 7 EGFR EGFR NNP cord-010092-uftc8inx 8993 8 ) ) -RRB- cord-010092-uftc8inx 8993 9 was be VBD cord-010092-uftc8inx 8993 10 used use VBN cord-010092-uftc8inx 8993 11 as as IN cord-010092-uftc8inx 8993 12 targeted target VBN cord-010092-uftc8inx 8993 13 therapy therapy NN cord-010092-uftc8inx 8993 14 . . . cord-010092-uftc8inx 8994 1 Premedication Premedication NNP cord-010092-uftc8inx 8994 2 with with IN cord-010092-uftc8inx 8994 3 dexchlorpheniramine dexchlorpheniramine NN cord-010092-uftc8inx 8994 4 IV IV NNP cord-010092-uftc8inx 8994 5 was be VBD cord-010092-uftc8inx 8994 6 systematically systematically RB cord-010092-uftc8inx 8994 7 given give VBN cord-010092-uftc8inx 8994 8 at at IN cord-010092-uftc8inx 8994 9 the the DT cord-010092-uftc8inx 8994 10 beginning beginning NN cord-010092-uftc8inx 8994 11 of of IN cord-010092-uftc8inx 8994 12 each each DT cord-010092-uftc8inx 8994 13 cycle cycle NN cord-010092-uftc8inx 8994 14 of of IN cord-010092-uftc8inx 8994 15 treatment treatment NN cord-010092-uftc8inx 8994 16 to to TO cord-010092-uftc8inx 8994 17 reduce reduce VB cord-010092-uftc8inx 8994 18 the the DT cord-010092-uftc8inx 8994 19 risk risk NN cord-010092-uftc8inx 8994 20 of of IN cord-010092-uftc8inx 8994 21 perfusion perfusion NN cord-010092-uftc8inx 8994 22 reactions reaction NNS cord-010092-uftc8inx 8994 23 mainly mainly RB cord-010092-uftc8inx 8994 24 associated associate VBN cord-010092-uftc8inx 8994 25 with with IN cord-010092-uftc8inx 8994 26 Panitumumab Panitumumab NNP cord-010092-uftc8inx 8994 27 . . . cord-010092-uftc8inx 8995 1 The the DT cord-010092-uftc8inx 8995 2 patient patient NN cord-010092-uftc8inx 8995 3 developed develop VBD cord-010092-uftc8inx 8995 4 chills chill NNS cord-010092-uftc8inx 8995 5 and and CC cord-010092-uftc8inx 8995 6 febrile febrile JJ cord-010092-uftc8inx 8995 7 agranulocytosis agranulocytosis NN cord-010092-uftc8inx 8995 8 during during IN cord-010092-uftc8inx 8995 9 the the DT cord-010092-uftc8inx 8995 10 first first JJ cord-010092-uftc8inx 8995 11 and and CC cord-010092-uftc8inx 8995 12 second second JJ cord-010092-uftc8inx 8995 13 infusion infusion NN cord-010092-uftc8inx 8995 14 respectively respectively RB cord-010092-uftc8inx 8995 15 . . . cord-010092-uftc8inx 8996 1 The the DT cord-010092-uftc8inx 8996 2 third third JJ cord-010092-uftc8inx 8996 3 infusion infusion NN cord-010092-uftc8inx 8996 4 was be VBD cord-010092-uftc8inx 8996 5 not not RB cord-010092-uftc8inx 8996 6 performed perform VBN cord-010092-uftc8inx 8996 7 due due IN cord-010092-uftc8inx 8996 8 to to IN cord-010092-uftc8inx 8996 9 pyrexia pyrexia NNP cord-010092-uftc8inx 8996 10 , , , cord-010092-uftc8inx 8996 11 chills chill NNS cord-010092-uftc8inx 8996 12 , , , cord-010092-uftc8inx 8996 13 general general JJ cord-010092-uftc8inx 8996 14 discomfort discomfort NN cord-010092-uftc8inx 8996 15 experienced experience VBN cord-010092-uftc8inx 8996 16 by by IN cord-010092-uftc8inx 8996 17 the the DT cord-010092-uftc8inx 8996 18 patient patient NN cord-010092-uftc8inx 8996 19 at at IN cord-010092-uftc8inx 8996 20 the the DT cord-010092-uftc8inx 8996 21 beginning beginning NN cord-010092-uftc8inx 8996 22 of of IN cord-010092-uftc8inx 8996 23 chemotherapy chemotherapy NN cord-010092-uftc8inx 8996 24 . . . cord-010092-uftc8inx 8997 1 Probabilistic probabilistic JJ cord-010092-uftc8inx 8997 2 antibiotherapy antibiotherapy NN cord-010092-uftc8inx 8997 3 was be VBD cord-010092-uftc8inx 8997 4 administered administer VBN cord-010092-uftc8inx 8997 5 and and CC cord-010092-uftc8inx 8997 6 the the DT cord-010092-uftc8inx 8997 7 patient patient NN cord-010092-uftc8inx 8997 8 recovered recover VBD cord-010092-uftc8inx 8997 9 rapidly rapidly RB cord-010092-uftc8inx 8997 10 . . . cord-010092-uftc8inx 8998 1 During during IN cord-010092-uftc8inx 8998 2 the the DT cord-010092-uftc8inx 8998 3 next next JJ cord-010092-uftc8inx 8998 4 infusion infusion NN cord-010092-uftc8inx 8998 5 ( ( -LRB- cord-010092-uftc8inx 8998 6 day day NN cord-010092-uftc8inx 8998 7 1 1 CD cord-010092-uftc8inx 8998 8 ) ) -RRB- cord-010092-uftc8inx 8998 9 , , , cord-010092-uftc8inx 8998 10 following follow VBG cord-010092-uftc8inx 8998 11 premedication premedication NN cord-010092-uftc8inx 8998 12 with with IN cord-010092-uftc8inx 8998 13 dexchlorpheniramine dexchlorpheniramine NNP cord-010092-uftc8inx 8998 14 , , , cord-010092-uftc8inx 8998 15 a a DT cord-010092-uftc8inx 8998 16 more more RBR cord-010092-uftc8inx 8998 17 " " `` cord-010092-uftc8inx 8998 18 impressive impressive JJ cord-010092-uftc8inx 8998 19 " " '' cord-010092-uftc8inx 8998 20 reaction reaction NN cord-010092-uftc8inx 8998 21 including include VBG cord-010092-uftc8inx 8998 22 all all PDT cord-010092-uftc8inx 8998 23 the the DT cord-010092-uftc8inx 8998 24 above above RB cord-010092-uftc8inx 8998 25 mentioned mention VBN cord-010092-uftc8inx 8998 26 symptoms symptom NNS cord-010092-uftc8inx 8998 27 occured occur VBD cord-010092-uftc8inx 8998 28 along along RB cord-010092-uftc8inx 8998 29 with with IN cord-010092-uftc8inx 8998 30 back back JJ cord-010092-uftc8inx 8998 31 pain pain NN cord-010092-uftc8inx 8998 32 and and CC cord-010092-uftc8inx 8998 33 dark dark JJ cord-010092-uftc8inx 8998 34 colored colored JJ cord-010092-uftc8inx 8998 35 urine urine NN cord-010092-uftc8inx 8998 36 . . . cord-010092-uftc8inx 8999 1 The the DT cord-010092-uftc8inx 8999 2 infusion infusion NN cord-010092-uftc8inx 8999 3 was be VBD cord-010092-uftc8inx 8999 4 halted halt VBN cord-010092-uftc8inx 8999 5 and and CC cord-010092-uftc8inx 8999 6 no no DT cord-010092-uftc8inx 8999 7 chemotherapy chemotherapy NN cord-010092-uftc8inx 8999 8 was be VBD cord-010092-uftc8inx 8999 9 delivered deliver VBN cord-010092-uftc8inx 8999 10 . . . cord-010092-uftc8inx 9000 1 Bacterial bacterial JJ cord-010092-uftc8inx 9000 2 infection infection NN cord-010092-uftc8inx 9000 3 at at IN cord-010092-uftc8inx 9000 4 the the DT cord-010092-uftc8inx 9000 5 implantable implantable JJ cord-010092-uftc8inx 9000 6 port port NN cord-010092-uftc8inx 9000 7 was be VBD cord-010092-uftc8inx 9000 8 first first RB cord-010092-uftc8inx 9000 9 thought think VBN cord-010092-uftc8inx 9000 10 to to TO cord-010092-uftc8inx 9000 11 be be VB cord-010092-uftc8inx 9000 12 the the DT cord-010092-uftc8inx 9000 13 cause cause NN cord-010092-uftc8inx 9000 14 of of IN cord-010092-uftc8inx 9000 15 this this DT cord-010092-uftc8inx 9000 16 adverse adverse JJ cord-010092-uftc8inx 9000 17 event event NN cord-010092-uftc8inx 9000 18 but but CC cord-010092-uftc8inx 9000 19 was be VBD cord-010092-uftc8inx 9000 20 not not RB cord-010092-uftc8inx 9000 21 confirmed confirm VBN cord-010092-uftc8inx 9000 22 . . . cord-010092-uftc8inx 9001 1 Additional additional JJ cord-010092-uftc8inx 9001 2 laboratory laboratory NN cord-010092-uftc8inx 9001 3 findings finding NNS cord-010092-uftc8inx 9001 4 revealed reveal VBD cord-010092-uftc8inx 9001 5 biological biological JJ cord-010092-uftc8inx 9001 6 signs sign NNS cord-010092-uftc8inx 9001 7 of of IN cord-010092-uftc8inx 9001 8 inflammation inflammation NN cord-010092-uftc8inx 9001 9 associated associate VBN cord-010092-uftc8inx 9001 10 with with IN cord-010092-uftc8inx 9001 11 IHA IHA NNP cord-010092-uftc8inx 9001 12 and and CC cord-010092-uftc8inx 9001 13 acute acute JJ cord-010092-uftc8inx 9001 14 renal renal JJ cord-010092-uftc8inx 9001 15 failure failure NN cord-010092-uftc8inx 9001 16 . . . cord-010092-uftc8inx 9002 1 The the DT cord-010092-uftc8inx 9002 2 patient patient NN cord-010092-uftc8inx 9002 3 was be VBD cord-010092-uftc8inx 9002 4 treated treat VBN cord-010092-uftc8inx 9002 5 with with IN cord-010092-uftc8inx 9002 6 hemodialysis hemodialysis NN cord-010092-uftc8inx 9002 7 ( ( -LRB- cord-010092-uftc8inx 9002 8 day day NN cord-010092-uftc8inx 9002 9 5 5 CD cord-010092-uftc8inx 9002 10 ) ) -RRB- cord-010092-uftc8inx 9002 11 , , , cord-010092-uftc8inx 9002 12 two two CD cord-010092-uftc8inx 9002 13 units unit NNS cord-010092-uftc8inx 9002 14 of of IN cord-010092-uftc8inx 9002 15 RBCs rbc NNS cord-010092-uftc8inx 9002 16 ( ( -LRB- cord-010092-uftc8inx 9002 17 day day NN cord-010092-uftc8inx 9002 18 6 6 CD cord-010092-uftc8inx 9002 19 ) ) -RRB- cord-010092-uftc8inx 9002 20 and and CC cord-010092-uftc8inx 9002 21 was be VBD cord-010092-uftc8inx 9002 22 discharged discharge VBN cord-010092-uftc8inx 9002 23 one one CD cord-010092-uftc8inx 9002 24 week week NN cord-010092-uftc8inx 9002 25 later later RB cord-010092-uftc8inx 9002 26 in in IN cord-010092-uftc8inx 9002 27 stable stable JJ cord-010092-uftc8inx 9002 28 condition condition NN cord-010092-uftc8inx 9002 29 . . . cord-010092-uftc8inx 9003 1 Dexchlorpheniramine Dexchlorpheniramine NNP cord-010092-uftc8inx 9003 2 was be VBD cord-010092-uftc8inx 9003 3 then then RB cord-010092-uftc8inx 9003 4 suspected suspect VBN cord-010092-uftc8inx 9003 5 and and CC cord-010092-uftc8inx 9003 6 samples sample NNS cord-010092-uftc8inx 9003 7 collected collect VBN cord-010092-uftc8inx 9003 8 on on IN cord-010092-uftc8inx 9003 9 day day NN cord-010092-uftc8inx 9003 10 24 24 CD cord-010092-uftc8inx 9003 11 were be VBD cord-010092-uftc8inx 9003 12 sent send VBN cord-010092-uftc8inx 9003 13 for for IN cord-010092-uftc8inx 9003 14 a a DT cord-010092-uftc8inx 9003 15 DIIHA DIIHA NNP cord-010092-uftc8inx 9003 16 laboratory laboratory NN cord-010092-uftc8inx 9003 17 workup workup NN cord-010092-uftc8inx 9003 18 . . . cord-010092-uftc8inx 9004 1 Aims aim VBZ cord-010092-uftc8inx 9004 2 : : : cord-010092-uftc8inx 9005 1 The the DT cord-010092-uftc8inx 9005 2 aim aim NN cord-010092-uftc8inx 9005 3 of of IN cord-010092-uftc8inx 9005 4 this this DT cord-010092-uftc8inx 9005 5 study study NN cord-010092-uftc8inx 9005 6 was be VBD cord-010092-uftc8inx 9005 7 to to TO cord-010092-uftc8inx 9005 8 support support VB cord-010092-uftc8inx 9005 9 a a DT cord-010092-uftc8inx 9005 10 clinical clinical JJ cord-010092-uftc8inx 9005 11 diagnosis diagnosis NN cord-010092-uftc8inx 9005 12 of of IN cord-010092-uftc8inx 9005 13 DIIHA DIIHA NNP cord-010092-uftc8inx 9005 14 . . . cord-010092-uftc8inx 9006 1 Methods method NNS cord-010092-uftc8inx 9006 2 : : : cord-010092-uftc8inx 9007 1 Laboratory laboratory NN cord-010092-uftc8inx 9007 2 workup workup NN cord-010092-uftc8inx 9007 3 included include VBD cord-010092-uftc8inx 9007 4 direct direct JJ cord-010092-uftc8inx 9007 5 and and CC cord-010092-uftc8inx 9007 6 indirect indirect JJ cord-010092-uftc8inx 9007 7 antiglobulin antiglobulin NN cord-010092-uftc8inx 9007 8 tests test NNS cord-010092-uftc8inx 9007 9 ( ( -LRB- cord-010092-uftc8inx 9007 10 DAT DAT NNP cord-010092-uftc8inx 9007 11 and and CC cord-010092-uftc8inx 9007 12 IAT IAT NNP cord-010092-uftc8inx 9007 13 ) ) -RRB- cord-010092-uftc8inx 9007 14 . . . cord-010092-uftc8inx 9008 1 Drug drug NN cord-010092-uftc8inx 9008 2 antibodies antibody NNS cord-010092-uftc8inx 9008 3 investigation investigation NN cord-010092-uftc8inx 9008 4 was be VBD cord-010092-uftc8inx 9008 5 performed perform VBN cord-010092-uftc8inx 9008 6 by by IN cord-010092-uftc8inx 9008 7 incubating incubate VBG cord-010092-uftc8inx 9008 8 patient patient NN cord-010092-uftc8inx 9008 9 's 's POS cord-010092-uftc8inx 9008 10 serum serum NN cord-010092-uftc8inx 9008 11 and and CC cord-010092-uftc8inx 9008 12 eluate eluate NN cord-010092-uftc8inx 9008 13 from from IN cord-010092-uftc8inx 9008 14 patient patient NN cord-010092-uftc8inx 9008 15 's 's POS cord-010092-uftc8inx 9008 16 RBCs rbc NNS cord-010092-uftc8inx 9008 17 in in IN cord-010092-uftc8inx 9008 18 the the DT cord-010092-uftc8inx 9008 19 presence presence NN cord-010092-uftc8inx 9008 20 of of IN cord-010092-uftc8inx 9008 21 drug drug NN cord-010092-uftc8inx 9008 22 against against IN cord-010092-uftc8inx 9008 23 normal normal JJ cord-010092-uftc8inx 9008 24 donor donor NN cord-010092-uftc8inx 9008 25 RBCs rbc NNS cord-010092-uftc8inx 9008 26 that that WDT cord-010092-uftc8inx 9008 27 had have VBD cord-010092-uftc8inx 9008 28 not not RB cord-010092-uftc8inx 9008 29 been be VBN cord-010092-uftc8inx 9008 30 previously previously RB cord-010092-uftc8inx 9008 31 treated treat VBN cord-010092-uftc8inx 9008 32 with with IN cord-010092-uftc8inx 9008 33 the the DT cord-010092-uftc8inx 9008 34 drug drug NN cord-010092-uftc8inx 9008 35 ( ( -LRB- cord-010092-uftc8inx 9008 36 i.e. i.e. FW cord-010092-uftc8inx 9008 37 , , , cord-010092-uftc8inx 9008 38 by by IN cord-010092-uftc8inx 9008 39 the the DT cord-010092-uftc8inx 9008 40 so so RB cord-010092-uftc8inx 9008 41 - - HYPH cord-010092-uftc8inx 9008 42 called call VBN cord-010092-uftc8inx 9008 43 " " `` cord-010092-uftc8inx 9008 44 immune immune JJ cord-010092-uftc8inx 9008 45 complex complex NN cord-010092-uftc8inx 9008 46 " " '' cord-010092-uftc8inx 9008 47 method method NN cord-010092-uftc8inx 9008 48 ) ) -RRB- cord-010092-uftc8inx 9008 49 . . . cord-010092-uftc8inx 9009 1 Control control NN cord-010092-uftc8inx 9009 2 tests test NNS cord-010092-uftc8inx 9009 3 were be VBD cord-010092-uftc8inx 9009 4 performed perform VBN cord-010092-uftc8inx 9009 5 in in IN cord-010092-uftc8inx 9009 6 parallel parallel NN cord-010092-uftc8inx 9009 7 . . . cord-010092-uftc8inx 9010 1 Drug drug NN cord-010092-uftc8inx 9010 2 was be VBD cord-010092-uftc8inx 9010 3 diluted dilute VBN cord-010092-uftc8inx 9010 4 in in IN cord-010092-uftc8inx 9010 5 PBS PBS NNP cord-010092-uftc8inx 9010 6 and and CC cord-010092-uftc8inx 9010 7 tested test VBD cord-010092-uftc8inx 9010 8 at at IN cord-010092-uftc8inx 9010 9 1 1 CD cord-010092-uftc8inx 9010 10 and and CC cord-010092-uftc8inx 9010 11 5 5 CD cord-010092-uftc8inx 9010 12 mg mg NNP cord-010092-uftc8inx 9010 13 / / SYM cord-010092-uftc8inx 9010 14 ml ml NN cord-010092-uftc8inx 9010 15 . . . cord-010092-uftc8inx 9011 1 Results result NNS cord-010092-uftc8inx 9012 1 : : : cord-010092-uftc8inx 9012 2 DAT DAT NNP cord-010092-uftc8inx 9012 3 was be VBD cord-010092-uftc8inx 9012 4 positive positive JJ cord-010092-uftc8inx 9012 5 ( ( -LRB- cord-010092-uftc8inx 9012 6 anti anti JJ cord-010092-uftc8inx 9012 7 - - JJ cord-010092-uftc8inx 9012 8 IgG igg JJ cord-010092-uftc8inx 9012 9 2 2 CD cord-010092-uftc8inx 9012 10 + + SYM cord-010092-uftc8inx 9012 11 , , , cord-010092-uftc8inx 9012 12 anti anti JJ cord-010092-uftc8inx 9012 13 - - JJ cord-010092-uftc8inx 9012 14 C3d c3d JJ cord-010092-uftc8inx 9012 15 2 2 CD cord-010092-uftc8inx 9012 16 + + CD cord-010092-uftc8inx 9012 17 ) ) -RRB- cord-010092-uftc8inx 9012 18 and and CC cord-010092-uftc8inx 9012 19 no no DT cord-010092-uftc8inx 9012 20 unexpected unexpected JJ cord-010092-uftc8inx 9012 21 RBCs rbc NNS cord-010092-uftc8inx 9012 22 antibodies antibody NNS cord-010092-uftc8inx 9012 23 were be VBD cord-010092-uftc8inx 9012 24 detected detect VBN cord-010092-uftc8inx 9012 25 by by IN cord-010092-uftc8inx 9012 26 IAT IAT NNP cord-010092-uftc8inx 9012 27 in in IN cord-010092-uftc8inx 9012 28 patient patient NN cord-010092-uftc8inx 9012 29 's 's POS cord-010092-uftc8inx 9012 30 serum serum NN cord-010092-uftc8inx 9012 31 and and CC cord-010092-uftc8inx 9012 32 eluate eluate NN cord-010092-uftc8inx 9012 33 without without IN cord-010092-uftc8inx 9012 34 the the DT cord-010092-uftc8inx 9012 35 in in FW cord-010092-uftc8inx 9012 36 vitro vitro FW cord-010092-uftc8inx 9012 37 addition addition NN cord-010092-uftc8inx 9012 38 of of IN cord-010092-uftc8inx 9012 39 the the DT cord-010092-uftc8inx 9012 40 drug drug NN cord-010092-uftc8inx 9012 41 . . . cord-010092-uftc8inx 9013 1 An an DT cord-010092-uftc8inx 9013 2 antibody antibody NN cord-010092-uftc8inx 9013 3 directed direct VBN cord-010092-uftc8inx 9013 4 against against IN cord-010092-uftc8inx 9013 5 untreated untreated JJ cord-010092-uftc8inx 9013 6 ( ( -LRB- cord-010092-uftc8inx 9013 7 titer titer NN cord-010092-uftc8inx 9013 8 2 2 CD cord-010092-uftc8inx 9013 9 ) ) -RRB- cord-010092-uftc8inx 9013 10 and and CC cord-010092-uftc8inx 9013 11 enzymetreated enzymetreate VBN cord-010092-uftc8inx 9013 12 ( ( -LRB- cord-010092-uftc8inx 9013 13 titer titer NN cord-010092-uftc8inx 9013 14 8) 8) NNP cord-010092-uftc8inx 9013 15 normal normal JJ cord-010092-uftc8inx 9013 16 donor donor NN cord-010092-uftc8inx 9013 17 RBCs rbc NNS cord-010092-uftc8inx 9013 18 was be VBD cord-010092-uftc8inx 9013 19 demonstrated demonstrate VBN cord-010092-uftc8inx 9013 20 only only RB cord-010092-uftc8inx 9013 21 in in IN cord-010092-uftc8inx 9013 22 patient patient NN cord-010092-uftc8inx 9013 23 's 's POS cord-010092-uftc8inx 9013 24 serum serum NN cord-010092-uftc8inx 9013 25 in in IN cord-010092-uftc8inx 9013 26 the the DT cord-010092-uftc8inx 9013 27 presence presence NN cord-010092-uftc8inx 9013 28 of of IN cord-010092-uftc8inx 9013 29 the the DT cord-010092-uftc8inx 9013 30 drug drug NN cord-010092-uftc8inx 9013 31 tested test VBN cord-010092-uftc8inx 9013 32 at at IN cord-010092-uftc8inx 9013 33 5 5 CD cord-010092-uftc8inx 9013 34 mg mg NNP cord-010092-uftc8inx 9013 35 / / SYM cord-010092-uftc8inx 9013 36 ml ml XX cord-010092-uftc8inx 9013 37 by by IN cord-010092-uftc8inx 9013 38 the the DT cord-010092-uftc8inx 9013 39 gel gel NN cord-010092-uftc8inx 9013 40 method method NN cord-010092-uftc8inx 9013 41 . . . cord-010092-uftc8inx 9014 1 The the DT cord-010092-uftc8inx 9014 2 pool pool NN cord-010092-uftc8inx 9014 3 of of IN cord-010092-uftc8inx 9014 4 normal normal JJ cord-010092-uftc8inx 9014 5 sera sera NNP cord-010092-uftc8inx 9014 6 did do VBD cord-010092-uftc8inx 9014 7 not not RB cord-010092-uftc8inx 9014 8 react react VB cord-010092-uftc8inx 9014 9 in in IN cord-010092-uftc8inx 9014 10 the the DT cord-010092-uftc8inx 9014 11 presence presence NN cord-010092-uftc8inx 9014 12 of of IN cord-010092-uftc8inx 9014 13 the the DT cord-010092-uftc8inx 9014 14 drug drug NN cord-010092-uftc8inx 9014 15 . . . cord-010092-uftc8inx 9015 1 Summary Summary NNP cord-010092-uftc8inx 9015 2 / / SYM cord-010092-uftc8inx 9015 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 9015 4 : : : cord-010092-uftc8inx 9016 1 The the DT cord-010092-uftc8inx 9016 2 multi multi JJ cord-010092-uftc8inx 9016 3 - - JJ cord-010092-uftc8inx 9016 4 drug drug JJ cord-010092-uftc8inx 9016 5 treated treat VBN cord-010092-uftc8inx 9016 6 patient patient NN cord-010092-uftc8inx 9016 7 described describe VBN cord-010092-uftc8inx 9016 8 in in IN cord-010092-uftc8inx 9016 9 this this DT cord-010092-uftc8inx 9016 10 study study NN cord-010092-uftc8inx 9016 11 was be VBD cord-010092-uftc8inx 9016 12 demonstrated demonstrate VBN cord-010092-uftc8inx 9016 13 to to TO cord-010092-uftc8inx 9016 14 have have VB cord-010092-uftc8inx 9016 15 dexchlorpheniramine dexchlorpheniramine JJ cord-010092-uftc8inx 9016 16 dependent dependent JJ cord-010092-uftc8inx 9016 17 antibody antibody NN cord-010092-uftc8inx 9016 18 detected detect VBN cord-010092-uftc8inx 9016 19 by by IN cord-010092-uftc8inx 9016 20 the the DT cord-010092-uftc8inx 9016 21 " " `` cord-010092-uftc8inx 9016 22 immune immune JJ cord-010092-uftc8inx 9016 23 complex complex NN cord-010092-uftc8inx 9016 24 " " '' cord-010092-uftc8inx 9016 25 method method NN cord-010092-uftc8inx 9016 26 . . . cord-010092-uftc8inx 9017 1 The the DT cord-010092-uftc8inx 9017 2 key key NN cord-010092-uftc8inx 9017 3 to to IN cord-010092-uftc8inx 9017 4 the the DT cord-010092-uftc8inx 9017 5 diagnosis diagnosis NN cord-010092-uftc8inx 9017 6 was be VBD cord-010092-uftc8inx 9017 7 the the DT cord-010092-uftc8inx 9017 8 observation observation NN cord-010092-uftc8inx 9017 9 of of IN cord-010092-uftc8inx 9017 10 positive positive JJ cord-010092-uftc8inx 9017 11 DAT DAT NNP cord-010092-uftc8inx 9017 12 with with IN cord-010092-uftc8inx 9017 13 negative negative JJ cord-010092-uftc8inx 9017 14 eluate eluate JJ cord-010092-uftc8inx 9017 15 tests test NNS cord-010092-uftc8inx 9017 16 which which WDT cord-010092-uftc8inx 9017 17 prompted prompt VBD cord-010092-uftc8inx 9017 18 a a DT cord-010092-uftc8inx 9017 19 reexamination reexamination NN cord-010092-uftc8inx 9017 20 of of IN cord-010092-uftc8inx 9017 21 the the DT cord-010092-uftc8inx 9017 22 medications medication NNS cord-010092-uftc8inx 9017 23 administered administer VBN cord-010092-uftc8inx 9017 24 in in IN cord-010092-uftc8inx 9017 25 temporal temporal JJ cord-010092-uftc8inx 9017 26 relationship relationship NN cord-010092-uftc8inx 9017 27 with with IN cord-010092-uftc8inx 9017 28 the the DT cord-010092-uftc8inx 9017 29 hemolytic hemolytic JJ cord-010092-uftc8inx 9017 30 event event NN cord-010092-uftc8inx 9017 31 . . . cord-010092-uftc8inx 9018 1 Although although IN cord-010092-uftc8inx 9018 2 rare rare JJ cord-010092-uftc8inx 9018 3 , , , cord-010092-uftc8inx 9018 4 this this DT cord-010092-uftc8inx 9018 5 case case NN cord-010092-uftc8inx 9018 6 report report NN cord-010092-uftc8inx 9018 7 should should MD cord-010092-uftc8inx 9018 8 alert alert VB cord-010092-uftc8inx 9018 9 physicians physician NNS cord-010092-uftc8inx 9018 10 to to IN cord-010092-uftc8inx 9018 11 the the DT cord-010092-uftc8inx 9018 12 need need NN cord-010092-uftc8inx 9018 13 to to TO cord-010092-uftc8inx 9018 14 investigate investigate VB cord-010092-uftc8inx 9018 15 the the DT cord-010092-uftc8inx 9018 16 possibility possibility NN cord-010092-uftc8inx 9018 17 of of IN cord-010092-uftc8inx 9018 18 dexchlorpheniramine dexchlorpheniramine NN cord-010092-uftc8inx 9018 19 induced induce VBN cord-010092-uftc8inx 9018 20 hemolytic hemolytic JJ cord-010092-uftc8inx 9018 21 anemia anemia NN cord-010092-uftc8inx 9018 22 in in IN cord-010092-uftc8inx 9018 23 any any DT cord-010092-uftc8inx 9018 24 patient patient NN cord-010092-uftc8inx 9018 25 who who WP cord-010092-uftc8inx 9018 26 develop develop VBP cord-010092-uftc8inx 9018 27 unexpected unexpected JJ cord-010092-uftc8inx 9018 28 anemia anemia NN cord-010092-uftc8inx 9018 29 after after IN cord-010092-uftc8inx 9018 30 hematologic hematologic JJ cord-010092-uftc8inx 9018 31 or or CC cord-010092-uftc8inx 9018 32 oncologic oncologic JJ cord-010092-uftc8inx 9018 33 procedures procedure NNS cord-010092-uftc8inx 9018 34 P-331 P-331 VBD cord-010092-uftc8inx 9018 35 Singapore Singapore NNP cord-010092-uftc8inx 9018 36 , , , cord-010092-uftc8inx 9018 37 Singapore Singapore NNP cord-010092-uftc8inx 9018 38 , , , cord-010092-uftc8inx 9018 39 Singapore Singapore NNP cord-010092-uftc8inx 9018 40 Background Background NNP cord-010092-uftc8inx 9018 41 : : : cord-010092-uftc8inx 9018 42 Daratumumab Daratumumab NNP cord-010092-uftc8inx 9018 43 is be VBZ cord-010092-uftc8inx 9018 44 a a DT cord-010092-uftc8inx 9018 45 monoclonal monoclonal JJ cord-010092-uftc8inx 9018 46 antibody antibody NN cord-010092-uftc8inx 9018 47 against against IN cord-010092-uftc8inx 9018 48 CD38 CD38 NNP cord-010092-uftc8inx 9018 49 used use VBN cord-010092-uftc8inx 9018 50 in in IN cord-010092-uftc8inx 9018 51 the the DT cord-010092-uftc8inx 9018 52 treatment treatment NN cord-010092-uftc8inx 9018 53 of of IN cord-010092-uftc8inx 9018 54 multiple multiple JJ cord-010092-uftc8inx 9018 55 myeloma myeloma NN cord-010092-uftc8inx 9018 56 and and CC cord-010092-uftc8inx 9018 57 has have VBZ cord-010092-uftc8inx 9018 58 been be VBN cord-010092-uftc8inx 9018 59 known know VBN cord-010092-uftc8inx 9018 60 to to TO cord-010092-uftc8inx 9018 61 bind bind VB cord-010092-uftc8inx 9018 62 to to IN cord-010092-uftc8inx 9018 63 CD38 CD38 NNP cord-010092-uftc8inx 9018 64 on on IN cord-010092-uftc8inx 9018 65 RBC RBC NNP cord-010092-uftc8inx 9018 66 's 's POS cord-010092-uftc8inx 9018 67 and and CC cord-010092-uftc8inx 9018 68 interfere interfere VB cord-010092-uftc8inx 9018 69 with with IN cord-010092-uftc8inx 9018 70 indirect indirect JJ cord-010092-uftc8inx 9018 71 antiglobulin antiglobulin NN cord-010092-uftc8inx 9018 72 based base VBN cord-010092-uftc8inx 9018 73 serologic serologic NNP cord-010092-uftc8inx 9018 74 tests test NNS cord-010092-uftc8inx 9018 75 such such JJ cord-010092-uftc8inx 9018 76 as as IN cord-010092-uftc8inx 9018 77 red red JJ cord-010092-uftc8inx 9018 78 cell cell NN cord-010092-uftc8inx 9018 79 antibody antibody NN cord-010092-uftc8inx 9018 80 screens screen NNS cord-010092-uftc8inx 9018 81 and and CC cord-010092-uftc8inx 9018 82 crossmatch crossmatch NN cord-010092-uftc8inx 9018 83 compatibility compatibility NN cord-010092-uftc8inx 9018 84 testing testing NN cord-010092-uftc8inx 9018 85 . . . cord-010092-uftc8inx 9019 1 In in IN cord-010092-uftc8inx 9019 2 order order NN cord-010092-uftc8inx 9019 3 to to TO cord-010092-uftc8inx 9019 4 negate negate VB cord-010092-uftc8inx 9019 5 the the DT cord-010092-uftc8inx 9019 6 interference interference NN cord-010092-uftc8inx 9019 7 of of IN cord-010092-uftc8inx 9019 8 Daratumumab Daratumumab NNP cord-010092-uftc8inx 9019 9 , , , cord-010092-uftc8inx 9019 10 our -PRON- PRP$ cord-010092-uftc8inx 9019 11 reference reference NN cord-010092-uftc8inx 9019 12 laboratory laboratory NN cord-010092-uftc8inx 9019 13 follows follow VBZ cord-010092-uftc8inx 9019 14 the the DT cord-010092-uftc8inx 9019 15 Daratumumab Daratumumab NNP cord-010092-uftc8inx 9019 16 protocol protocol NN cord-010092-uftc8inx 9019 17 recommended recommend VBN cord-010092-uftc8inx 9019 18 by by IN cord-010092-uftc8inx 9019 19 the the DT cord-010092-uftc8inx 9019 20 AABB AABB NNP cord-010092-uftc8inx 9019 21 which which WDT cord-010092-uftc8inx 9019 22 uses use VBZ cord-010092-uftc8inx 9019 23 Dithiothreitol Dithiothreitol NNP cord-010092-uftc8inx 9019 24 ( ( -LRB- cord-010092-uftc8inx 9019 25 DTT DTT NNP cord-010092-uftc8inx 9019 26 ) ) -RRB- cord-010092-uftc8inx 9019 27 treated treat VBD cord-010092-uftc8inx 9019 28 reagent reagent NN cord-010092-uftc8inx 9019 29 red red JJ cord-010092-uftc8inx 9019 30 cells cell NNS cord-010092-uftc8inx 9019 31 in in IN cord-010092-uftc8inx 9019 32 red red JJ cord-010092-uftc8inx 9019 33 cell cell NN cord-010092-uftc8inx 9019 34 antibody antibody NN cord-010092-uftc8inx 9019 35 screening screening NN cord-010092-uftc8inx 9019 36 and and CC cord-010092-uftc8inx 9019 37 identification identification NN cord-010092-uftc8inx 9019 38 test test NN cord-010092-uftc8inx 9019 39 in in IN cord-010092-uftc8inx 9019 40 patients patient NNS cord-010092-uftc8inx 9019 41 known know VBN cord-010092-uftc8inx 9019 42 to to TO cord-010092-uftc8inx 9019 43 have have VB cord-010092-uftc8inx 9019 44 received receive VBN cord-010092-uftc8inx 9019 45 Daratumumab Daratumumab NNP cord-010092-uftc8inx 9019 46 . . . cord-010092-uftc8inx 9020 1 Aims aim VBZ cord-010092-uftc8inx 9020 2 : : : cord-010092-uftc8inx 9021 1 The the DT cord-010092-uftc8inx 9021 2 objective objective NN cord-010092-uftc8inx 9021 3 of of IN cord-010092-uftc8inx 9021 4 this this DT cord-010092-uftc8inx 9021 5 study study NN cord-010092-uftc8inx 9021 6 is be VBZ cord-010092-uftc8inx 9021 7 to to TO cord-010092-uftc8inx 9021 8 determine determine VB cord-010092-uftc8inx 9021 9 the the DT cord-010092-uftc8inx 9021 10 impact impact NN cord-010092-uftc8inx 9021 11 of of IN cord-010092-uftc8inx 9021 12 Daratumumab Daratumumab NNP cord-010092-uftc8inx 9021 13 in in IN cord-010092-uftc8inx 9021 14 the the DT cord-010092-uftc8inx 9021 15 turnaround turnaround NN cord-010092-uftc8inx 9021 16 time time NN cord-010092-uftc8inx 9021 17 ( ( -LRB- cord-010092-uftc8inx 9021 18 TAT tat NN cord-010092-uftc8inx 9021 19 ) ) -RRB- cord-010092-uftc8inx 9021 20 for for IN cord-010092-uftc8inx 9021 21 red red JJ cord-010092-uftc8inx 9021 22 cell cell NN cord-010092-uftc8inx 9021 23 antibody antibody NN cord-010092-uftc8inx 9021 24 screening screening NN cord-010092-uftc8inx 9021 25 and and CC cord-010092-uftc8inx 9021 26 identification identification NN cord-010092-uftc8inx 9021 27 . . . cord-010092-uftc8inx 9022 1 Methods method NNS cord-010092-uftc8inx 9022 2 : : : cord-010092-uftc8inx 9023 1 A a DT cord-010092-uftc8inx 9023 2 retrospective retrospective JJ cord-010092-uftc8inx 9023 3 review review NN cord-010092-uftc8inx 9023 4 of of IN cord-010092-uftc8inx 9023 5 the the DT cord-010092-uftc8inx 9023 6 TAT tat NN cord-010092-uftc8inx 9023 7 for for IN cord-010092-uftc8inx 9023 8 red red JJ cord-010092-uftc8inx 9023 9 cell cell NN cord-010092-uftc8inx 9023 10 antibody antibody NN cord-010092-uftc8inx 9023 11 screening screening NN cord-010092-uftc8inx 9023 12 and and CC cord-010092-uftc8inx 9023 13 identification identification NN cord-010092-uftc8inx 9023 14 samples sample NNS cord-010092-uftc8inx 9023 15 of of IN cord-010092-uftc8inx 9023 16 patients patient NNS cord-010092-uftc8inx 9023 17 known know VBN cord-010092-uftc8inx 9023 18 to to TO cord-010092-uftc8inx 9023 19 be be VB cord-010092-uftc8inx 9023 20 treated treat VBN cord-010092-uftc8inx 9023 21 with with IN cord-010092-uftc8inx 9023 22 daratumumab daratumumab NNP cord-010092-uftc8inx 9023 23 from from IN cord-010092-uftc8inx 9023 24 October October NNP cord-010092-uftc8inx 9023 25 2016 2016 CD cord-010092-uftc8inx 9023 26 to to IN cord-010092-uftc8inx 9023 27 December December NNP cord-010092-uftc8inx 9023 28 2018 2018 CD cord-010092-uftc8inx 9023 29 was be VBD cord-010092-uftc8inx 9023 30 performed perform VBN cord-010092-uftc8inx 9023 31 . . . cord-010092-uftc8inx 9024 1 Turnaround turnaround NN cord-010092-uftc8inx 9024 2 time time NN cord-010092-uftc8inx 9024 3 is be VBZ cord-010092-uftc8inx 9024 4 defined define VBN cord-010092-uftc8inx 9024 5 as as IN cord-010092-uftc8inx 9024 6 the the DT cord-010092-uftc8inx 9024 7 time time NN cord-010092-uftc8inx 9024 8 the the DT cord-010092-uftc8inx 9024 9 sample sample NN cord-010092-uftc8inx 9024 10 is be VBZ cord-010092-uftc8inx 9024 11 received receive VBN cord-010092-uftc8inx 9024 12 up up RP cord-010092-uftc8inx 9024 13 the the DT cord-010092-uftc8inx 9024 14 time time NN cord-010092-uftc8inx 9024 15 the the DT cord-010092-uftc8inx 9024 16 results result NNS cord-010092-uftc8inx 9024 17 were be VBD cord-010092-uftc8inx 9024 18 reported report VBN cord-010092-uftc8inx 9024 19 . . . cord-010092-uftc8inx 9025 1 The the DT cord-010092-uftc8inx 9025 2 TAT tat NN cord-010092-uftc8inx 9025 3 for for IN cord-010092-uftc8inx 9025 4 routine routine JJ cord-010092-uftc8inx 9025 5 red red JJ cord-010092-uftc8inx 9025 6 cell cell NN cord-010092-uftc8inx 9025 7 antibody antibody NN cord-010092-uftc8inx 9025 8 screen screen NN cord-010092-uftc8inx 9025 9 and and CC cord-010092-uftc8inx 9025 10 identifications identification NNS cord-010092-uftc8inx 9025 11 were be VBD cord-010092-uftc8inx 9025 12 also also RB cord-010092-uftc8inx 9025 13 reviewed review VBN cord-010092-uftc8inx 9025 14 during during IN cord-010092-uftc8inx 9025 15 the the DT cord-010092-uftc8inx 9025 16 same same JJ cord-010092-uftc8inx 9025 17 period period NN cord-010092-uftc8inx 9025 18 and and CC cord-010092-uftc8inx 9025 19 was be VBD cord-010092-uftc8inx 9025 20 compared compare VBN cord-010092-uftc8inx 9025 21 with with IN cord-010092-uftc8inx 9025 22 the the DT cord-010092-uftc8inx 9025 23 TAT tat NN cord-010092-uftc8inx 9025 24 of of IN cord-010092-uftc8inx 9025 25 samples sample NNS cord-010092-uftc8inx 9025 26 from from IN cord-010092-uftc8inx 9025 27 patients patient NNS cord-010092-uftc8inx 9025 28 treated treat VBN cord-010092-uftc8inx 9025 29 with with IN cord-010092-uftc8inx 9025 30 daratumumab daratumumab NNP cord-010092-uftc8inx 9025 31 . . . cord-010092-uftc8inx 9026 1 Results result NNS cord-010092-uftc8inx 9026 2 : : : cord-010092-uftc8inx 9027 1 A a DT cord-010092-uftc8inx 9027 2 total total NN cord-010092-uftc8inx 9027 3 of of IN cord-010092-uftc8inx 9027 4 55 55 CD cord-010092-uftc8inx 9027 5 patients patient NNS cord-010092-uftc8inx 9027 6 on on IN cord-010092-uftc8inx 9027 7 daratumumab daratumumab NNP cord-010092-uftc8inx 9027 8 had have VBD cord-010092-uftc8inx 9027 9 samples sample NNS cord-010092-uftc8inx 9027 10 sent send VBN cord-010092-uftc8inx 9027 11 to to IN cord-010092-uftc8inx 9027 12 our -PRON- PRP$ cord-010092-uftc8inx 9027 13 reference reference NN cord-010092-uftc8inx 9027 14 laboratory laboratory NN cord-010092-uftc8inx 9027 15 for for IN cord-010092-uftc8inx 9027 16 red red JJ cord-010092-uftc8inx 9027 17 cell cell NN cord-010092-uftc8inx 9027 18 antibody antibody NN cord-010092-uftc8inx 9027 19 screen screen NN cord-010092-uftc8inx 9027 20 and and CC cord-010092-uftc8inx 9027 21 identification identification NN cord-010092-uftc8inx 9027 22 during during IN cord-010092-uftc8inx 9027 23 the the DT cord-010092-uftc8inx 9027 24 study study NN cord-010092-uftc8inx 9027 25 period period NN cord-010092-uftc8inx 9027 26 . . . cord-010092-uftc8inx 9028 1 Information information NN cord-010092-uftc8inx 9028 2 on on IN cord-010092-uftc8inx 9028 3 daratumumab daratumumab JJ cord-010092-uftc8inx 9028 4 treatment treatment NN cord-010092-uftc8inx 9028 5 was be VBD cord-010092-uftc8inx 9028 6 not not RB cord-010092-uftc8inx 9028 7 provided provide VBN cord-010092-uftc8inx 9028 8 to to IN cord-010092-uftc8inx 9028 9 the the DT cord-010092-uftc8inx 9028 10 reference reference NN cord-010092-uftc8inx 9028 11 lab lab NN cord-010092-uftc8inx 9028 12 prior prior RB cord-010092-uftc8inx 9028 13 to to IN cord-010092-uftc8inx 9028 14 the the DT cord-010092-uftc8inx 9028 15 start start NN cord-010092-uftc8inx 9028 16 of of IN cord-010092-uftc8inx 9028 17 testing testing NN cord-010092-uftc8inx 9028 18 in in IN cord-010092-uftc8inx 9028 19 23 23 CD cord-010092-uftc8inx 9028 20 of of IN cord-010092-uftc8inx 9028 21 the the DT cord-010092-uftc8inx 9028 22 55 55 CD cord-010092-uftc8inx 9028 23 patients patient NNS cord-010092-uftc8inx 9028 24 while while IN cord-010092-uftc8inx 9028 25 the the DT cord-010092-uftc8inx 9028 26 use use NN cord-010092-uftc8inx 9028 27 daratumumab daratumumab NNP cord-010092-uftc8inx 9028 28 was be VBD cord-010092-uftc8inx 9028 29 mentioned mention VBN cord-010092-uftc8inx 9028 30 in in IN cord-010092-uftc8inx 9028 31 the the DT cord-010092-uftc8inx 9028 32 serology serology NN cord-010092-uftc8inx 9028 33 request request NN cord-010092-uftc8inx 9028 34 form form NN cord-010092-uftc8inx 9028 35 of of IN cord-010092-uftc8inx 9028 36 the the DT cord-010092-uftc8inx 9028 37 other other JJ cord-010092-uftc8inx 9028 38 32 32 CD cord-010092-uftc8inx 9028 39 patients patient NNS cord-010092-uftc8inx 9028 40 . . . cord-010092-uftc8inx 9029 1 The the DT cord-010092-uftc8inx 9029 2 median median NN cord-010092-uftc8inx 9029 3 TAT tat NN cord-010092-uftc8inx 9029 4 for for IN cord-010092-uftc8inx 9029 5 red red JJ cord-010092-uftc8inx 9029 6 cell cell NN cord-010092-uftc8inx 9029 7 antibody antibody NN cord-010092-uftc8inx 9029 8 screen screen NN cord-010092-uftc8inx 9029 9 and and CC cord-010092-uftc8inx 9029 10 identification identification NN cord-010092-uftc8inx 9029 11 is be VBZ cord-010092-uftc8inx 9029 12 212 212 CD cord-010092-uftc8inx 9029 13 min min NN cord-010092-uftc8inx 9029 14 ( ( -LRB- cord-010092-uftc8inx 9029 15 range range NN cord-010092-uftc8inx 9029 16 : : : cord-010092-uftc8inx 9029 17 47 47 CD cord-010092-uftc8inx 9029 18 - - SYM cord-010092-uftc8inx 9029 19 877 877 CD cord-010092-uftc8inx 9029 20 ) ) -RRB- cord-010092-uftc8inx 9029 21 if if IN cord-010092-uftc8inx 9029 22 information information NN cord-010092-uftc8inx 9029 23 on on IN cord-010092-uftc8inx 9029 24 daratumumab daratumumab NNP cord-010092-uftc8inx 9029 25 was be VBD cord-010092-uftc8inx 9029 26 provided provide VBN cord-010092-uftc8inx 9029 27 prior prior RB cord-010092-uftc8inx 9029 28 to to TO cord-010092-uftc8inx 9029 29 start start NN cord-010092-uftc8inx 9029 30 of of IN cord-010092-uftc8inx 9029 31 testing testing NN cord-010092-uftc8inx 9029 32 and and CC cord-010092-uftc8inx 9029 33 301 301 CD cord-010092-uftc8inx 9029 34 min min NN cord-010092-uftc8inx 9029 35 ( ( -LRB- cord-010092-uftc8inx 9029 36 range range NN cord-010092-uftc8inx 9029 37 : : : cord-010092-uftc8inx 9029 38 133 133 CD cord-010092-uftc8inx 9029 39 - - SYM cord-010092-uftc8inx 9029 40 1417 1417 CD cord-010092-uftc8inx 9029 41 ) ) -RRB- cord-010092-uftc8inx 9029 42 if if IN cord-010092-uftc8inx 9029 43 information information NN cord-010092-uftc8inx 9029 44 was be VBD cord-010092-uftc8inx 9029 45 not not RB cord-010092-uftc8inx 9029 46 provided provide VBN cord-010092-uftc8inx 9029 47 prior prior RB cord-010092-uftc8inx 9029 48 to to IN cord-010092-uftc8inx 9029 49 testing testing NN cord-010092-uftc8inx 9029 50 . . . cord-010092-uftc8inx 9030 1 The the DT cord-010092-uftc8inx 9030 2 median median NN cord-010092-uftc8inx 9030 3 TAT tat NN cord-010092-uftc8inx 9030 4 for for IN cord-010092-uftc8inx 9030 5 routine routine JJ cord-010092-uftc8inx 9030 6 testing testing NN cord-010092-uftc8inx 9030 7 is be VBZ cord-010092-uftc8inx 9030 8 198 198 CD cord-010092-uftc8inx 9030 9 min min NN cord-010092-uftc8inx 9030 10 ( ( -LRB- cord-010092-uftc8inx 9030 11 range range NN cord-010092-uftc8inx 9030 12 : : : cord-010092-uftc8inx 9030 13 15 15 CD cord-010092-uftc8inx 9030 14 - - SYM cord-010092-uftc8inx 9030 15 2245 2245 CD cord-010092-uftc8inx 9030 16 ) ) -RRB- cord-010092-uftc8inx 9030 17 . . . cord-010092-uftc8inx 9031 1 Using use VBG cord-010092-uftc8inx 9031 2 Wilcoxon Wilcoxon NNP cord-010092-uftc8inx 9031 3 rank rank NN cord-010092-uftc8inx 9031 4 - - HYPH cord-010092-uftc8inx 9031 5 sum sum NN cord-010092-uftc8inx 9031 6 test test NN cord-010092-uftc8inx 9031 7 , , , cord-010092-uftc8inx 9031 8 turn turn NN cord-010092-uftc8inx 9031 9 - - HYPH cord-010092-uftc8inx 9031 10 around around RP cord-010092-uftc8inx 9031 11 time time NN cord-010092-uftc8inx 9031 12 for for IN cord-010092-uftc8inx 9031 13 antibody antibody NN cord-010092-uftc8inx 9031 14 screening screening NN cord-010092-uftc8inx 9031 15 and and CC cord-010092-uftc8inx 9031 16 identification identification NN cord-010092-uftc8inx 9031 17 for for IN cord-010092-uftc8inx 9031 18 daratumumab daratumumab NNP cord-010092-uftc8inx 9031 19 treated treat VBN cord-010092-uftc8inx 9031 20 patients patient NNS cord-010092-uftc8inx 9031 21 was be VBD cord-010092-uftc8inx 9031 22 observed observe VBN cord-010092-uftc8inx 9031 23 as as IN cord-010092-uftc8inx 9031 24 statistically statistically RB cord-010092-uftc8inx 9031 25 not not RB cord-010092-uftc8inx 9031 26 significant significant JJ cord-010092-uftc8inx 9031 27 when when WRB cord-010092-uftc8inx 9031 28 compared compare VBN cord-010092-uftc8inx 9031 29 to to IN cord-010092-uftc8inx 9031 30 routine routine JJ cord-010092-uftc8inx 9031 31 samples sample NNS cord-010092-uftc8inx 9031 32 ( ( -LRB- cord-010092-uftc8inx 9031 33 P p NN cord-010092-uftc8inx 9031 34 value value NN cord-010092-uftc8inx 9031 35 0.72634 0.72634 CD cord-010092-uftc8inx 9031 36 ) ) -RRB- cord-010092-uftc8inx 9031 37 . . . cord-010092-uftc8inx 9032 1 However however RB cord-010092-uftc8inx 9032 2 , , , cord-010092-uftc8inx 9032 3 TAT tat NN cord-010092-uftc8inx 9032 4 for for IN cord-010092-uftc8inx 9032 5 serologic serologic NNP cord-010092-uftc8inx 9032 6 tests test NNS cord-010092-uftc8inx 9032 7 requests request NNS cord-010092-uftc8inx 9032 8 with with IN cord-010092-uftc8inx 9032 9 appropriate appropriate JJ cord-010092-uftc8inx 9032 10 medical medical JJ cord-010092-uftc8inx 9032 11 history history NN cord-010092-uftc8inx 9032 12 compared compare VBN cord-010092-uftc8inx 9032 13 to to IN cord-010092-uftc8inx 9032 14 the the DT cord-010092-uftc8inx 9032 15 testing testing NN cord-010092-uftc8inx 9032 16 requests request NNS cord-010092-uftc8inx 9032 17 without without IN cord-010092-uftc8inx 9032 18 relevant relevant JJ cord-010092-uftc8inx 9032 19 information information NN cord-010092-uftc8inx 9032 20 was be VBD cord-010092-uftc8inx 9032 21 also also RB cord-010092-uftc8inx 9032 22 observed observe VBN cord-010092-uftc8inx 9032 23 to to TO cord-010092-uftc8inx 9032 24 be be VB cord-010092-uftc8inx 9032 25 significantly significantly RB cord-010092-uftc8inx 9032 26 difference difference NN cord-010092-uftc8inx 9032 27 ( ( -LRB- cord-010092-uftc8inx 9032 28 P p NN cord-010092-uftc8inx 9032 29 value value NN cord-010092-uftc8inx 9032 30 0.00694 0.00694 CD cord-010092-uftc8inx 9032 31 ) ) -RRB- cord-010092-uftc8inx 9032 32 . . . cord-010092-uftc8inx 9033 1 Summary Summary NNP cord-010092-uftc8inx 9033 2 / / SYM cord-010092-uftc8inx 9033 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 9033 4 : : : cord-010092-uftc8inx 9034 1 There there EX cord-010092-uftc8inx 9034 2 is be VBZ cord-010092-uftc8inx 9034 3 no no DT cord-010092-uftc8inx 9034 4 significant significant JJ cord-010092-uftc8inx 9034 5 impact impact NN cord-010092-uftc8inx 9034 6 in in IN cord-010092-uftc8inx 9034 7 the the DT cord-010092-uftc8inx 9034 8 TAT tat NN cord-010092-uftc8inx 9034 9 of of IN cord-010092-uftc8inx 9034 10 red red JJ cord-010092-uftc8inx 9034 11 cell cell NN cord-010092-uftc8inx 9034 12 antibody antibody NN cord-010092-uftc8inx 9034 13 screen screen NN cord-010092-uftc8inx 9034 14 and and CC cord-010092-uftc8inx 9034 15 identification identification NN cord-010092-uftc8inx 9034 16 in in IN cord-010092-uftc8inx 9034 17 patients patient NNS cord-010092-uftc8inx 9034 18 known know VBN cord-010092-uftc8inx 9034 19 to to TO cord-010092-uftc8inx 9034 20 receive receive VB cord-010092-uftc8inx 9034 21 daratumumab daratumumab VBN cord-010092-uftc8inx 9034 22 as as IN cord-010092-uftc8inx 9034 23 compared compare VBN cord-010092-uftc8inx 9034 24 to to IN cord-010092-uftc8inx 9034 25 routine routine JJ cord-010092-uftc8inx 9034 26 testing testing NN cord-010092-uftc8inx 9034 27 . . . cord-010092-uftc8inx 9035 1 However however RB cord-010092-uftc8inx 9035 2 , , , cord-010092-uftc8inx 9035 3 there there EX cord-010092-uftc8inx 9035 4 is be VBZ cord-010092-uftc8inx 9035 5 a a DT cord-010092-uftc8inx 9035 6 significant significant JJ cord-010092-uftc8inx 9035 7 difference difference NN cord-010092-uftc8inx 9035 8 in in IN cord-010092-uftc8inx 9035 9 the the DT cord-010092-uftc8inx 9035 10 TAT tat NN cord-010092-uftc8inx 9035 11 if if IN cord-010092-uftc8inx 9035 12 information information NN cord-010092-uftc8inx 9035 13 on on IN cord-010092-uftc8inx 9035 14 daratumumab daratumumab JJ cord-010092-uftc8inx 9035 15 treatment treatment NN cord-010092-uftc8inx 9035 16 is be VBZ cord-010092-uftc8inx 9035 17 not not RB cord-010092-uftc8inx 9035 18 provided provide VBN cord-010092-uftc8inx 9035 19 prior prior RB cord-010092-uftc8inx 9035 20 to to IN cord-010092-uftc8inx 9035 21 testing testing NN cord-010092-uftc8inx 9035 22 . . . cord-010092-uftc8inx 9036 1 This this DT cord-010092-uftc8inx 9036 2 highlights highlight VBZ cord-010092-uftc8inx 9036 3 the the DT cord-010092-uftc8inx 9036 4 importance importance NN cord-010092-uftc8inx 9036 5 of of IN cord-010092-uftc8inx 9036 6 providing provide VBG cord-010092-uftc8inx 9036 7 the the DT cord-010092-uftc8inx 9036 8 relevant relevant JJ cord-010092-uftc8inx 9036 9 medication medication NN cord-010092-uftc8inx 9036 10 information information NN cord-010092-uftc8inx 9036 11 in in IN cord-010092-uftc8inx 9036 12 the the DT cord-010092-uftc8inx 9036 13 request request NN cord-010092-uftc8inx 9036 14 form form NN cord-010092-uftc8inx 9036 15 in in IN cord-010092-uftc8inx 9036 16 order order NN cord-010092-uftc8inx 9036 17 to to TO cord-010092-uftc8inx 9036 18 prevent prevent VB cord-010092-uftc8inx 9036 19 delays delay NNS cord-010092-uftc8inx 9036 20 in in IN cord-010092-uftc8inx 9036 21 testing testing NN cord-010092-uftc8inx 9036 22 and and CC cord-010092-uftc8inx 9036 23 provision provision NN cord-010092-uftc8inx 9036 24 of of IN cord-010092-uftc8inx 9036 25 blood blood NN cord-010092-uftc8inx 9036 26 to to IN cord-010092-uftc8inx 9036 27 patients patient NNS cord-010092-uftc8inx 9036 28 on on IN cord-010092-uftc8inx 9036 29 daratumumab daratumumab NNP cord-010092-uftc8inx 9036 30 , , , cord-010092-uftc8inx 9036 31 which which WDT cord-010092-uftc8inx 9036 32 can can MD cord-010092-uftc8inx 9036 33 result result VB cord-010092-uftc8inx 9036 34 in in IN cord-010092-uftc8inx 9036 35 improved improve VBN cord-010092-uftc8inx 9036 36 organizational organizational JJ cord-010092-uftc8inx 9036 37 efficiency efficiency NN cord-010092-uftc8inx 9036 38 and and CC cord-010092-uftc8inx 9036 39 have have VB cord-010092-uftc8inx 9036 40 positive positive JJ cord-010092-uftc8inx 9036 41 impact impact NN cord-010092-uftc8inx 9036 42 on on IN cord-010092-uftc8inx 9036 43 cost cost NN cord-010092-uftc8inx 9036 44 and and CC cord-010092-uftc8inx 9036 45 resource resource NN cord-010092-uftc8inx 9036 46 savings saving NNS cord-010092-uftc8inx 9036 47 . . . cord-010092-uftc8inx 9037 1 Background background NN cord-010092-uftc8inx 9037 2 : : : cord-010092-uftc8inx 9037 3 Daratumumab Daratumumab NNP cord-010092-uftc8inx 9037 4 , , , cord-010092-uftc8inx 9037 5 an an DT cord-010092-uftc8inx 9037 6 anti anti JJ cord-010092-uftc8inx 9037 7 - - JJ cord-010092-uftc8inx 9037 8 CD38 cd38 JJ cord-010092-uftc8inx 9037 9 monoclonal monoclonal JJ cord-010092-uftc8inx 9037 10 antibody antibody NN cord-010092-uftc8inx 9037 11 , , , cord-010092-uftc8inx 9037 12 has have VBZ cord-010092-uftc8inx 9037 13 been be VBN cord-010092-uftc8inx 9037 14 shown show VBN cord-010092-uftc8inx 9037 15 to to TO cord-010092-uftc8inx 9037 16 be be VB cord-010092-uftc8inx 9037 17 highly highly RB cord-010092-uftc8inx 9037 18 efficacious efficacious JJ cord-010092-uftc8inx 9037 19 in in IN cord-010092-uftc8inx 9037 20 the the DT cord-010092-uftc8inx 9037 21 treatment treatment NN cord-010092-uftc8inx 9037 22 of of IN cord-010092-uftc8inx 9037 23 Multiple Multiple NNP cord-010092-uftc8inx 9037 24 Myeloma Myeloma NNP cord-010092-uftc8inx 9037 25 ( ( -LRB- cord-010092-uftc8inx 9037 26 MM MM NNP cord-010092-uftc8inx 9037 27 ) ) -RRB- cord-010092-uftc8inx 9037 28 . . . cord-010092-uftc8inx 9038 1 CD38 CD38 NNP cord-010092-uftc8inx 9038 2 is be VBZ cord-010092-uftc8inx 9038 3 a a DT cord-010092-uftc8inx 9038 4 glycoprotein glycoprotein NN cord-010092-uftc8inx 9038 5 highly highly RB cord-010092-uftc8inx 9038 6 expressed express VBN cord-010092-uftc8inx 9038 7 on on IN cord-010092-uftc8inx 9038 8 plasma plasma NN cord-010092-uftc8inx 9038 9 cells cell NNS cord-010092-uftc8inx 9038 10 and and CC cord-010092-uftc8inx 9038 11 , , , cord-010092-uftc8inx 9038 12 to to IN cord-010092-uftc8inx 9038 13 a a DT cord-010092-uftc8inx 9038 14 less less JJR cord-010092-uftc8inx 9038 15 extend extend NN cord-010092-uftc8inx 9038 16 , , , cord-010092-uftc8inx 9038 17 on on IN cord-010092-uftc8inx 9038 18 the the DT cord-010092-uftc8inx 9038 19 surface surface NN cord-010092-uftc8inx 9038 20 of of IN cord-010092-uftc8inx 9038 21 red red JJ cord-010092-uftc8inx 9038 22 blood blood NN cord-010092-uftc8inx 9038 23 cells cell NNS cord-010092-uftc8inx 9038 24 ( ( -LRB- cord-010092-uftc8inx 9038 25 RBC RBC NNP cord-010092-uftc8inx 9038 26 ) ) -RRB- cord-010092-uftc8inx 9038 27 . . . cord-010092-uftc8inx 9039 1 When when WRB cord-010092-uftc8inx 9039 2 bound bind VBN cord-010092-uftc8inx 9039 3 to to IN cord-010092-uftc8inx 9039 4 CD38 CD38 NNP cord-010092-uftc8inx 9039 5 on on IN cord-010092-uftc8inx 9039 6 RBC RBC NNP cord-010092-uftc8inx 9039 7 , , , cord-010092-uftc8inx 9039 8 daratumumab daratumumab NNP cord-010092-uftc8inx 9039 9 interferes interfere VBZ cord-010092-uftc8inx 9039 10 with with IN cord-010092-uftc8inx 9039 11 the the DT cord-010092-uftc8inx 9039 12 pretransfusion pretransfusion NN cord-010092-uftc8inx 9039 13 tests test NNS cord-010092-uftc8inx 9039 14 , , , cord-010092-uftc8inx 9039 15 with with IN cord-010092-uftc8inx 9039 16 positive positive JJ cord-010092-uftc8inx 9039 17 antibody antibody NN cord-010092-uftc8inx 9039 18 screening screening NN cord-010092-uftc8inx 9039 19 and and CC cord-010092-uftc8inx 9039 20 crossmatch crossmatch NN cord-010092-uftc8inx 9039 21 . . . cord-010092-uftc8inx 9040 1 Anti anti JJ cord-010092-uftc8inx 9040 2 - - JJ cord-010092-uftc8inx 9040 3 CD38 cd38 JJ cord-010092-uftc8inx 9040 4 interference interference NN cord-010092-uftc8inx 9040 5 is be VBZ cord-010092-uftc8inx 9040 6 an an DT cord-010092-uftc8inx 9040 7 important important JJ cord-010092-uftc8inx 9040 8 challenge challenge NN cord-010092-uftc8inx 9040 9 as as IN cord-010092-uftc8inx 9040 10 many many JJ cord-010092-uftc8inx 9040 11 MM MM NNP cord-010092-uftc8inx 9040 12 patients patient NNS cord-010092-uftc8inx 9040 13 will will MD cord-010092-uftc8inx 9040 14 require require VB cord-010092-uftc8inx 9040 15 blood blood NN cord-010092-uftc8inx 9040 16 transfusions transfusion NNS cord-010092-uftc8inx 9040 17 during during IN cord-010092-uftc8inx 9040 18 their -PRON- PRP$ cord-010092-uftc8inx 9040 19 treatment treatment NN cord-010092-uftc8inx 9040 20 . . . cord-010092-uftc8inx 9041 1 Dithiothreitol Dithiothreitol NNP cord-010092-uftc8inx 9041 2 is be VBZ cord-010092-uftc8inx 9041 3 a a DT cord-010092-uftc8inx 9041 4 reducing reduce VBG cord-010092-uftc8inx 9041 5 reagent reagent NN cord-010092-uftc8inx 9041 6 with with IN cord-010092-uftc8inx 9041 7 multiple multiple JJ cord-010092-uftc8inx 9041 8 applications application NNS cord-010092-uftc8inx 9041 9 in in IN cord-010092-uftc8inx 9041 10 blood blood NN cord-010092-uftc8inx 9041 11 bank bank NN cord-010092-uftc8inx 9041 12 testing testing NN cord-010092-uftc8inx 9041 13 . . . cord-010092-uftc8inx 9042 1 Treatment treatment NN cord-010092-uftc8inx 9042 2 of of IN cord-010092-uftc8inx 9042 3 RBC RBC NNP cord-010092-uftc8inx 9042 4 with with IN cord-010092-uftc8inx 9042 5 dithiothreitol dithiothreitol NNP cord-010092-uftc8inx 9042 6 irreversibly irreversibly RB cord-010092-uftc8inx 9042 7 removes remove VBZ cord-010092-uftc8inx 9042 8 cell cell NN cord-010092-uftc8inx 9042 9 surface surface NN cord-010092-uftc8inx 9042 10 CD38 CD38 NNP cord-010092-uftc8inx 9042 11 tertiary tertiary JJ cord-010092-uftc8inx 9042 12 structure structure NN cord-010092-uftc8inx 9042 13 , , , cord-010092-uftc8inx 9042 14 avoiding avoid VBG cord-010092-uftc8inx 9042 15 the the DT cord-010092-uftc8inx 9042 16 binding binding NN cord-010092-uftc8inx 9042 17 and and CC cord-010092-uftc8inx 9042 18 testing testing NN cord-010092-uftc8inx 9042 19 interference interference NN cord-010092-uftc8inx 9042 20 by by IN cord-010092-uftc8inx 9042 21 the the DT cord-010092-uftc8inx 9042 22 anti anti JJ cord-010092-uftc8inx 9042 23 - - JJ cord-010092-uftc8inx 9042 24 CD38 cd38 JJ cord-010092-uftc8inx 9042 25 daratumumab daratumumab VBD cord-010092-uftc8inx 9042 26 . . . cord-010092-uftc8inx 9043 1 Aims aim VBZ cord-010092-uftc8inx 9043 2 : : : cord-010092-uftc8inx 9044 1 To to TO cord-010092-uftc8inx 9044 2 demonstrate demonstrate VB cord-010092-uftc8inx 9044 3 the the DT cord-010092-uftc8inx 9044 4 efficacy efficacy NN cord-010092-uftc8inx 9044 5 , , , cord-010092-uftc8inx 9044 6 safety safety NN cord-010092-uftc8inx 9044 7 and and CC cord-010092-uftc8inx 9044 8 celerity celerity NN cord-010092-uftc8inx 9044 9 of of IN cord-010092-uftc8inx 9044 10 the the DT cord-010092-uftc8inx 9044 11 protocol protocol NN cord-010092-uftc8inx 9044 12 between between IN cord-010092-uftc8inx 9044 13 the the DT cord-010092-uftc8inx 9044 14 Blood Blood NNP cord-010092-uftc8inx 9044 15 Bank Bank NNP cord-010092-uftc8inx 9044 16 ( ( -LRB- cord-010092-uftc8inx 9044 17 BB BB NNP cord-010092-uftc8inx 9044 18 ) ) -RRB- cord-010092-uftc8inx 9044 19 and and CC cord-010092-uftc8inx 9044 20 Haemato Haemato NNP cord-010092-uftc8inx 9044 21 - - HYPH cord-010092-uftc8inx 9044 22 Oncology Oncology NNP cord-010092-uftc8inx 9044 23 of of IN cord-010092-uftc8inx 9044 24 our -PRON- PRP$ cord-010092-uftc8inx 9044 25 institutions institution NNS cord-010092-uftc8inx 9044 26 , , , cord-010092-uftc8inx 9044 27 using use VBG cord-010092-uftc8inx 9044 28 just just RB cord-010092-uftc8inx 9044 29 the the DT cord-010092-uftc8inx 9044 30 crossmatch crossmatch NN cord-010092-uftc8inx 9044 31 . . . cord-010092-uftc8inx 9045 1 Methods method NNS cord-010092-uftc8inx 9045 2 : : : cord-010092-uftc8inx 9046 1 A a DT cord-010092-uftc8inx 9046 2 retrospective retrospective JJ cord-010092-uftc8inx 9046 3 research research NN cord-010092-uftc8inx 9046 4 was be VBD cord-010092-uftc8inx 9046 5 used use VBN cord-010092-uftc8inx 9046 6 for for IN cord-010092-uftc8inx 9046 7 the the DT cord-010092-uftc8inx 9046 8 evaluation evaluation NN cord-010092-uftc8inx 9046 9 of of IN cord-010092-uftc8inx 9046 10 the the DT cord-010092-uftc8inx 9046 11 results result NNS cord-010092-uftc8inx 9046 12 obtained obtain VBN cord-010092-uftc8inx 9046 13 from from IN cord-010092-uftc8inx 9046 14 the the DT cord-010092-uftc8inx 9046 15 implemented implement VBN cord-010092-uftc8inx 9046 16 protocol protocol NN cord-010092-uftc8inx 9046 17 . . . cord-010092-uftc8inx 9047 1 This this DT cord-010092-uftc8inx 9047 2 comprehends comprehend VBZ cord-010092-uftc8inx 9047 3 a a DT cord-010092-uftc8inx 9047 4 previous previous JJ cord-010092-uftc8inx 9047 5 contact contact NN cord-010092-uftc8inx 9047 6 by by IN cord-010092-uftc8inx 9047 7 Haemato Haemato NNP cord-010092-uftc8inx 9047 8 - - HYPH cord-010092-uftc8inx 9047 9 Oncology Oncology NNP cord-010092-uftc8inx 9047 10 that that WDT cord-010092-uftc8inx 9047 11 leads lead VBZ cord-010092-uftc8inx 9047 12 to to IN cord-010092-uftc8inx 9047 13 a a DT cord-010092-uftc8inx 9047 14 study study NN cord-010092-uftc8inx 9047 15 of of IN cord-010092-uftc8inx 9047 16 the the DT cord-010092-uftc8inx 9047 17 patient patient NN cord-010092-uftc8inx 9047 18 before before IN cord-010092-uftc8inx 9047 19 the the DT cord-010092-uftc8inx 9047 20 beginning beginning NN cord-010092-uftc8inx 9047 21 of of IN cord-010092-uftc8inx 9047 22 Daratumumab Daratumumab NNP cord-010092-uftc8inx 9047 23 treatment treatment NN cord-010092-uftc8inx 9047 24 , , , cord-010092-uftc8inx 9047 25 and and CC cord-010092-uftc8inx 9047 26 consists consist VBZ cord-010092-uftc8inx 9047 27 in in IN cord-010092-uftc8inx 9047 28 : : : cord-010092-uftc8inx 9047 29 ABO ABO NNP cord-010092-uftc8inx 9047 30 / / SYM cord-010092-uftc8inx 9047 31 RhD rhd NN cord-010092-uftc8inx 9047 32 grouping grouping NN cord-010092-uftc8inx 9047 33 ; ; : cord-010092-uftc8inx 9047 34 Rh Rh NNP cord-010092-uftc8inx 9047 35 and and CC cord-010092-uftc8inx 9047 36 Kell Kell NNP cord-010092-uftc8inx 9047 37 phenotyping phenotyping NN cord-010092-uftc8inx 9047 38 , , , cord-010092-uftc8inx 9047 39 and and CC cord-010092-uftc8inx 9047 40 other other JJ cord-010092-uftc8inx 9047 41 clinically clinically RB cord-010092-uftc8inx 9047 42 significant significant JJ cord-010092-uftc8inx 9047 43 antigens antigen NNS cord-010092-uftc8inx 9047 44 ; ; : cord-010092-uftc8inx 9047 45 antibody antibody NN cord-010092-uftc8inx 9047 46 screening screening NN cord-010092-uftc8inx 9047 47 ; ; : cord-010092-uftc8inx 9047 48 and and CC cord-010092-uftc8inx 9047 49 direct direct JJ cord-010092-uftc8inx 9047 50 antiglobulin antiglobulin NN cord-010092-uftc8inx 9047 51 test test NN cord-010092-uftc8inx 9047 52 . . . cord-010092-uftc8inx 9048 1 Genotyping Genotyping NNP cord-010092-uftc8inx 9048 2 may may MD cord-010092-uftc8inx 9048 3 be be VB cord-010092-uftc8inx 9048 4 required require VBN cord-010092-uftc8inx 9048 5 for for IN cord-010092-uftc8inx 9048 6 some some DT cord-010092-uftc8inx 9048 7 patients patient NNS cord-010092-uftc8inx 9048 8 who who WP cord-010092-uftc8inx 9048 9 received receive VBD cord-010092-uftc8inx 9048 10 previous previous JJ cord-010092-uftc8inx 9048 11 blood blood NN cord-010092-uftc8inx 9048 12 transfusions transfusion NNS cord-010092-uftc8inx 9048 13 . . . cord-010092-uftc8inx 9049 1 Before before IN cord-010092-uftc8inx 9049 2 the the DT cord-010092-uftc8inx 9049 3 beginning beginning NN cord-010092-uftc8inx 9049 4 of of IN cord-010092-uftc8inx 9049 5 the the DT cord-010092-uftc8inx 9049 6 therapy therapy NN cord-010092-uftc8inx 9049 7 , , , cord-010092-uftc8inx 9049 8 a a DT cord-010092-uftc8inx 9049 9 blood blood NN cord-010092-uftc8inx 9049 10 sample sample NN cord-010092-uftc8inx 9049 11 of of IN cord-010092-uftc8inx 9049 12 the the DT cord-010092-uftc8inx 9049 13 patient patient NN cord-010092-uftc8inx 9049 14 is be VBZ cord-010092-uftc8inx 9049 15 sent send VBN cord-010092-uftc8inx 9049 16 to to IN cord-010092-uftc8inx 9049 17 the the DT cord-010092-uftc8inx 9049 18 BB BB NNP cord-010092-uftc8inx 9049 19 to to TO cord-010092-uftc8inx 9049 20 perform perform VB cord-010092-uftc8inx 9049 21 laboratory laboratory NN cord-010092-uftc8inx 9049 22 tests test NNS cord-010092-uftc8inx 9049 23 and and CC cord-010092-uftc8inx 9049 24 frozen freeze VBN cord-010092-uftc8inx 9049 25 after after IN cord-010092-uftc8inx 9049 26 . . . cord-010092-uftc8inx 9050 1 This this DT cord-010092-uftc8inx 9050 2 frozen frozen JJ cord-010092-uftc8inx 9050 3 sample sample NN cord-010092-uftc8inx 9050 4 is be VBZ cord-010092-uftc8inx 9050 5 used use VBN cord-010092-uftc8inx 9050 6 for for IN cord-010092-uftc8inx 9050 7 crossmatching crossmatche VBG cord-010092-uftc8inx 9050 8 in in IN cord-010092-uftc8inx 9050 9 patients patient NNS cord-010092-uftc8inx 9050 10 that that WDT cord-010092-uftc8inx 9050 11 already already RB cord-010092-uftc8inx 9050 12 started start VBD cord-010092-uftc8inx 9050 13 therapy therapy NN cord-010092-uftc8inx 9050 14 , , , cord-010092-uftc8inx 9050 15 did do VBD cord-010092-uftc8inx 9050 16 not not RB cord-010092-uftc8inx 9050 17 have have VB cord-010092-uftc8inx 9050 18 a a DT cord-010092-uftc8inx 9050 19 blood blood NN cord-010092-uftc8inx 9050 20 transfusion transfusion NN cord-010092-uftc8inx 9050 21 in in IN cord-010092-uftc8inx 9050 22 between between IN cord-010092-uftc8inx 9050 23 , , , cord-010092-uftc8inx 9050 24 and and CC cord-010092-uftc8inx 9050 25 have have VBP cord-010092-uftc8inx 9050 26 a a DT cord-010092-uftc8inx 9050 27 positive positive JJ cord-010092-uftc8inx 9050 28 antibody antibody NN cord-010092-uftc8inx 9050 29 screening screening NN cord-010092-uftc8inx 9050 30 and/or and/or CC cord-010092-uftc8inx 9050 31 crossmatch crossmatch NN cord-010092-uftc8inx 9050 32 . . . cord-010092-uftc8inx 9051 1 In in IN cord-010092-uftc8inx 9051 2 further further JJ cord-010092-uftc8inx 9051 3 transfusions transfusion NNS cord-010092-uftc8inx 9051 4 , , , cord-010092-uftc8inx 9051 5 in in IN cord-010092-uftc8inx 9051 6 case case NN cord-010092-uftc8inx 9051 7 of of IN cord-010092-uftc8inx 9051 8 positive positive JJ cord-010092-uftc8inx 9051 9 tests test NNS cord-010092-uftc8inx 9051 10 , , , cord-010092-uftc8inx 9051 11 the the DT cord-010092-uftc8inx 9051 12 dithiothreitol dithiothreitol NNP cord-010092-uftc8inx 9051 13 - - HYPH cord-010092-uftc8inx 9051 14 treated treat VBN cord-010092-uftc8inx 9051 15 donor donor NN cord-010092-uftc8inx 9051 16 RBC RBC NNP cord-010092-uftc8inx 9051 17 is be VBZ cord-010092-uftc8inx 9051 18 applied apply VBN cord-010092-uftc8inx 9051 19 . . . cord-010092-uftc8inx 9052 1 The the DT cord-010092-uftc8inx 9052 2 donor donor NN cord-010092-uftc8inx 9052 3 RBC RBC NNP cord-010092-uftc8inx 9052 4 antigens antigen NNS cord-010092-uftc8inx 9052 5 are be VBP cord-010092-uftc8inx 9052 6 always always RB cord-010092-uftc8inx 9052 7 selected select VBN cord-010092-uftc8inx 9052 8 accordingly accordingly RB cord-010092-uftc8inx 9052 9 to to IN cord-010092-uftc8inx 9052 10 patients patient NNS cord-010092-uftc8inx 9052 11 negative negative JJ cord-010092-uftc8inx 9052 12 clinically clinically RB cord-010092-uftc8inx 9052 13 significant significant JJ cord-010092-uftc8inx 9052 14 antigens antigen NNS cord-010092-uftc8inx 9052 15 , , , cord-010092-uftc8inx 9052 16 when when WRB cord-010092-uftc8inx 9052 17 transfusional transfusional JJ cord-010092-uftc8inx 9052 18 support support NN cord-010092-uftc8inx 9052 19 is be VBZ cord-010092-uftc8inx 9052 20 needed need VBN cord-010092-uftc8inx 9052 21 . . . cord-010092-uftc8inx 9053 1 The the DT cord-010092-uftc8inx 9053 2 laboratory laboratory NN cord-010092-uftc8inx 9053 3 tests test NNS cord-010092-uftc8inx 9053 4 are be VBP cord-010092-uftc8inx 9053 5 executed execute VBN cord-010092-uftc8inx 9053 6 in in IN cord-010092-uftc8inx 9053 7 gel gel NN cord-010092-uftc8inx 9053 8 column column NN cord-010092-uftc8inx 9053 9 agglutination agglutination NN cord-010092-uftc8inx 9053 10 technique technique NN cord-010092-uftc8inx 9053 11 . . . cord-010092-uftc8inx 9054 1 Results result NNS cord-010092-uftc8inx 9054 2 : : : cord-010092-uftc8inx 9054 3 Since since IN cord-010092-uftc8inx 9054 4 2016 2016 CD cord-010092-uftc8inx 9054 5 , , , cord-010092-uftc8inx 9054 6 32 32 CD cord-010092-uftc8inx 9054 7 patients patient NNS cord-010092-uftc8inx 9054 8 were be VBD cord-010092-uftc8inx 9054 9 studied study VBN cord-010092-uftc8inx 9054 10 , , , cord-010092-uftc8inx 9054 11 from from IN cord-010092-uftc8inx 9054 12 which which WDT cord-010092-uftc8inx 9054 13 16 16 CD cord-010092-uftc8inx 9054 14 were be VBD cord-010092-uftc8inx 9054 15 transfused transfuse VBN cord-010092-uftc8inx 9054 16 with with IN cord-010092-uftc8inx 9054 17 108 108 CD cord-010092-uftc8inx 9054 18 blood blood NN cord-010092-uftc8inx 9054 19 units unit NNS cord-010092-uftc8inx 9054 20 , , , cord-010092-uftc8inx 9054 21 according accord VBG cord-010092-uftc8inx 9054 22 to to IN cord-010092-uftc8inx 9054 23 the the DT cord-010092-uftc8inx 9054 24 protocol protocol NN cord-010092-uftc8inx 9054 25 . . . cord-010092-uftc8inx 9055 1 There there EX cord-010092-uftc8inx 9055 2 were be VBD cord-010092-uftc8inx 9055 3 no no DT cord-010092-uftc8inx 9055 4 immunizations immunization NNS cord-010092-uftc8inx 9055 5 or or CC cord-010092-uftc8inx 9055 6 adverse adverse JJ cord-010092-uftc8inx 9055 7 reactions reaction NNS cord-010092-uftc8inx 9055 8 to to IN cord-010092-uftc8inx 9055 9 transfusion transfusion NN cord-010092-uftc8inx 9055 10 registered register VBN cord-010092-uftc8inx 9055 11 within within IN cord-010092-uftc8inx 9055 12 the the DT cord-010092-uftc8inx 9055 13 transfused transfuse VBN cord-010092-uftc8inx 9055 14 patients patient NNS cord-010092-uftc8inx 9055 15 , , , cord-010092-uftc8inx 9055 16 neither neither CC cord-010092-uftc8inx 9055 17 delay delay VBP cord-010092-uftc8inx 9055 18 on on IN cord-010092-uftc8inx 9055 19 the the DT cord-010092-uftc8inx 9055 20 availability availability NN cord-010092-uftc8inx 9055 21 of of IN cord-010092-uftc8inx 9055 22 blood blood NN cord-010092-uftc8inx 9055 23 units unit NNS cord-010092-uftc8inx 9055 24 . . . cord-010092-uftc8inx 9056 1 Patient patient JJ cord-010092-uftc8inx 9056 2 blood blood NN cord-010092-uftc8inx 9056 3 sample sample NN cord-010092-uftc8inx 9056 4 collected collect VBN cord-010092-uftc8inx 9056 5 and and CC cord-010092-uftc8inx 9056 6 frozen freeze VBN cord-010092-uftc8inx 9056 7 prior prior RB cord-010092-uftc8inx 9056 8 to to IN cord-010092-uftc8inx 9056 9 the the DT cord-010092-uftc8inx 9056 10 beginning beginning NN cord-010092-uftc8inx 9056 11 of of IN cord-010092-uftc8inx 9056 12 the the DT cord-010092-uftc8inx 9056 13 treatment treatment NN cord-010092-uftc8inx 9056 14 , , , cord-010092-uftc8inx 9056 15 has have VBZ cord-010092-uftc8inx 9056 16 shown show VBN cord-010092-uftc8inx 9056 17 to to TO cord-010092-uftc8inx 9056 18 be be VB cord-010092-uftc8inx 9056 19 a a DT cord-010092-uftc8inx 9056 20 good good JJ cord-010092-uftc8inx 9056 21 strategy strategy NN cord-010092-uftc8inx 9056 22 by by IN cord-010092-uftc8inx 9056 23 reducing reduce VBG cord-010092-uftc8inx 9056 24 significantly significantly RB cord-010092-uftc8inx 9056 25 the the DT cord-010092-uftc8inx 9056 26 waiting wait VBG cord-010092-uftc8inx 9056 27 time time NN cord-010092-uftc8inx 9056 28 for for IN cord-010092-uftc8inx 9056 29 the the DT cord-010092-uftc8inx 9056 30 blood blood NN cord-010092-uftc8inx 9056 31 unit unit NN cord-010092-uftc8inx 9056 32 in in IN cord-010092-uftc8inx 9056 33 the the DT cord-010092-uftc8inx 9056 34 first first JJ cord-010092-uftc8inx 9056 35 transfusion transfusion NN cord-010092-uftc8inx 9056 36 . . . cord-010092-uftc8inx 9057 1 Summary Summary NNP cord-010092-uftc8inx 9057 2 / / SYM cord-010092-uftc8inx 9057 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 9057 4 : : : cord-010092-uftc8inx 9058 1 This this DT cord-010092-uftc8inx 9058 2 protocol protocol NN cord-010092-uftc8inx 9058 3 , , , cord-010092-uftc8inx 9058 4 which which WDT cord-010092-uftc8inx 9058 5 defines define VBZ cord-010092-uftc8inx 9058 6 the the DT cord-010092-uftc8inx 9058 7 communication communication NN cord-010092-uftc8inx 9058 8 among among IN cord-010092-uftc8inx 9058 9 the the DT cord-010092-uftc8inx 9058 10 involved involve VBN cord-010092-uftc8inx 9058 11 professionals professional NNS cord-010092-uftc8inx 9058 12 , , , cord-010092-uftc8inx 9058 13 has have VBZ cord-010092-uftc8inx 9058 14 shown show VBN cord-010092-uftc8inx 9058 15 to to TO cord-010092-uftc8inx 9058 16 be be VB cord-010092-uftc8inx 9058 17 a a DT cord-010092-uftc8inx 9058 18 secure secure JJ cord-010092-uftc8inx 9058 19 and and CC cord-010092-uftc8inx 9058 20 effective effective JJ cord-010092-uftc8inx 9058 21 way way NN cord-010092-uftc8inx 9058 22 of of IN cord-010092-uftc8inx 9058 23 reducing reduce VBG cord-010092-uftc8inx 9058 24 interferences interference NNS cord-010092-uftc8inx 9058 25 caused cause VBN cord-010092-uftc8inx 9058 26 by by IN cord-010092-uftc8inx 9058 27 Daratumumab Daratumumab NNP cord-010092-uftc8inx 9058 28 . . . cord-010092-uftc8inx 9059 1 It -PRON- PRP cord-010092-uftc8inx 9059 2 ensures ensure VBZ cord-010092-uftc8inx 9059 3 the the DT cord-010092-uftc8inx 9059 4 previous previous JJ cord-010092-uftc8inx 9059 5 study study NN cord-010092-uftc8inx 9059 6 of of IN cord-010092-uftc8inx 9059 7 the the DT cord-010092-uftc8inx 9059 8 patients patient NNS cord-010092-uftc8inx 9059 9 and and CC cord-010092-uftc8inx 9059 10 their -PRON- PRP$ cord-010092-uftc8inx 9059 11 transfusion transfusion NN cord-010092-uftc8inx 9059 12 with with IN cord-010092-uftc8inx 9059 13 RBC RBC NNP cord-010092-uftc8inx 9059 14 respecting respect VBG cord-010092-uftc8inx 9059 15 the the DT cord-010092-uftc8inx 9059 16 patients patient NNS cord-010092-uftc8inx 9059 17 negative negative JJ cord-010092-uftc8inx 9059 18 clinically clinically RB cord-010092-uftc8inx 9059 19 significant significant JJ cord-010092-uftc8inx 9059 20 antigens antigen NNS cord-010092-uftc8inx 9059 21 . . . cord-010092-uftc8inx 9060 1 If if IN cord-010092-uftc8inx 9060 2 not not RB cord-010092-uftc8inx 9060 3 adopted adopt VBN cord-010092-uftc8inx 9060 4 , , , cord-010092-uftc8inx 9060 5 the the DT cord-010092-uftc8inx 9060 6 mitigation mitigation NN cord-010092-uftc8inx 9060 7 measures measure NNS cord-010092-uftc8inx 9060 8 described describe VBN cord-010092-uftc8inx 9060 9 in in IN cord-010092-uftc8inx 9060 10 this this DT cord-010092-uftc8inx 9060 11 protocol protocol NN cord-010092-uftc8inx 9060 12 , , , cord-010092-uftc8inx 9060 13 delays delay NNS cord-010092-uftc8inx 9060 14 in in IN cord-010092-uftc8inx 9060 15 the the DT cord-010092-uftc8inx 9060 16 availability availability NN cord-010092-uftc8inx 9060 17 of of IN cord-010092-uftc8inx 9060 18 the the DT cord-010092-uftc8inx 9060 19 RBC RBC NNP cord-010092-uftc8inx 9060 20 requested request VBD cord-010092-uftc8inx 9060 21 and and CC cord-010092-uftc8inx 9060 22 alloimmunizations alloimmunization NNS cord-010092-uftc8inx 9060 23 , , , cord-010092-uftc8inx 9060 24 may may MD cord-010092-uftc8inx 9060 25 and and CC cord-010092-uftc8inx 9060 26 will will MD cord-010092-uftc8inx 9060 27 possibly possibly RB cord-010092-uftc8inx 9060 28 occur occur VB cord-010092-uftc8inx 9060 29 . . . cord-010092-uftc8inx 9061 1 A a DT cord-010092-uftc8inx 9061 2 good good JJ cord-010092-uftc8inx 9061 3 communication communication NN cord-010092-uftc8inx 9061 4 between between IN cord-010092-uftc8inx 9061 5 the the DT cord-010092-uftc8inx 9061 6 BB bb NN cord-010092-uftc8inx 9061 7 and and CC cord-010092-uftc8inx 9061 8 the the DT cord-010092-uftc8inx 9061 9 Haemato Haemato NNP cord-010092-uftc8inx 9061 10 - - HYPH cord-010092-uftc8inx 9061 11 Oncology Oncology NNP cord-010092-uftc8inx 9061 12 is be VBZ cord-010092-uftc8inx 9061 13 crucial crucial JJ cord-010092-uftc8inx 9061 14 for for IN cord-010092-uftc8inx 9061 15 a a DT cord-010092-uftc8inx 9061 16 good good JJ cord-010092-uftc8inx 9061 17 time time NN cord-010092-uftc8inx 9061 18 management management NN cord-010092-uftc8inx 9061 19 when when WRB cord-010092-uftc8inx 9061 20 a a DT cord-010092-uftc8inx 9061 21 transfusion transfusion NN cord-010092-uftc8inx 9061 22 is be VBZ cord-010092-uftc8inx 9061 23 requested request VBN cord-010092-uftc8inx 9061 24 for for IN cord-010092-uftc8inx 9061 25 these these DT cord-010092-uftc8inx 9061 26 patients patient NNS cord-010092-uftc8inx 9061 27 . . . cord-010092-uftc8inx 9062 1 Three three CD cord-010092-uftc8inx 9062 2 methods method NNS cord-010092-uftc8inx 9062 3 were be VBD cord-010092-uftc8inx 9062 4 used use VBN cord-010092-uftc8inx 9062 5 to to TO cord-010092-uftc8inx 9062 6 resolve resolve VB cord-010092-uftc8inx 9062 7 this this DT cord-010092-uftc8inx 9062 8 DARA DARA NNP cord-010092-uftc8inx 9062 9 interference interference NN cord-010092-uftc8inx 9062 10 . . . cord-010092-uftc8inx 9063 1 Reagent Reagent NNP cord-010092-uftc8inx 9063 2 RBC RBC NNP cord-010092-uftc8inx 9063 3 's 's POS cord-010092-uftc8inx 9063 4 were be VBD cord-010092-uftc8inx 9063 5 treated treat VBN cord-010092-uftc8inx 9063 6 with with IN cord-010092-uftc8inx 9063 7 DTT DTT NNP cord-010092-uftc8inx 9063 8 , , , cord-010092-uftc8inx 9063 9 which which WDT cord-010092-uftc8inx 9063 10 know know VBP cord-010092-uftc8inx 9063 11 to to TO cord-010092-uftc8inx 9063 12 denature denature VB cord-010092-uftc8inx 9063 13 CD38 CD38 NNP cord-010092-uftc8inx 9064 1 and and CC cord-010092-uftc8inx 9064 2 then then RB cord-010092-uftc8inx 9064 3 tested test VBN cord-010092-uftc8inx 9064 4 with with IN cord-010092-uftc8inx 9064 5 patient patient JJ cord-010092-uftc8inx 9064 6 plasma plasma NN cord-010092-uftc8inx 9064 7 . . . cord-010092-uftc8inx 9065 1 Allo allo NN cord-010092-uftc8inx 9065 2 - - HYPH cord-010092-uftc8inx 9065 3 adsorption adsorption NN cord-010092-uftc8inx 9065 4 study study NN cord-010092-uftc8inx 9065 5 was be VBD cord-010092-uftc8inx 9065 6 performed perform VBN cord-010092-uftc8inx 9065 7 using use VBG cord-010092-uftc8inx 9065 8 a a DT cord-010092-uftc8inx 9065 9 certain certain JJ cord-010092-uftc8inx 9065 10 ratio ratio NN cord-010092-uftc8inx 9065 11 of of IN cord-010092-uftc8inx 9065 12 red red JJ cord-010092-uftc8inx 9065 13 cells cell NNS cord-010092-uftc8inx 9065 14 to to IN cord-010092-uftc8inx 9065 15 plasma plasma NN cord-010092-uftc8inx 9065 16 . . . cord-010092-uftc8inx 9066 1 In in IN cord-010092-uftc8inx 9066 2 addition addition NN cord-010092-uftc8inx 9066 3 , , , cord-010092-uftc8inx 9066 4 a a DT cord-010092-uftc8inx 9066 5 selection selection NN cord-010092-uftc8inx 9066 6 of of IN cord-010092-uftc8inx 9066 7 phenotyped phenotype VBN cord-010092-uftc8inx 9066 8 cord cord NN cord-010092-uftc8inx 9066 9 cells cell NNS cord-010092-uftc8inx 9066 10 were be VBD cord-010092-uftc8inx 9066 11 used use VBN cord-010092-uftc8inx 9066 12 as as IN cord-010092-uftc8inx 9066 13 an an DT cord-010092-uftc8inx 9066 14 antibody antibody NN cord-010092-uftc8inx 9066 15 screening screening NN cord-010092-uftc8inx 9066 16 panel panel NN cord-010092-uftc8inx 9066 17 . . . cord-010092-uftc8inx 9067 1 Results result NNS cord-010092-uftc8inx 9067 2 : : : cord-010092-uftc8inx 9068 1 DTT DTT NNP cord-010092-uftc8inx 9068 2 treatment treatment NN cord-010092-uftc8inx 9068 3 of of IN cord-010092-uftc8inx 9068 4 reagent reagent JJ cord-010092-uftc8inx 9068 5 red red JJ cord-010092-uftc8inx 9068 6 cells cell NNS cord-010092-uftc8inx 9068 7 was be VBD cord-010092-uftc8inx 9068 8 successful successful JJ cord-010092-uftc8inx 9068 9 at at IN cord-010092-uftc8inx 9068 10 eliminating eliminate VBG cord-010092-uftc8inx 9068 11 DARA DARA NNP cord-010092-uftc8inx 9068 12 interference interference NN cord-010092-uftc8inx 9068 13 and and CC cord-010092-uftc8inx 9068 14 allowing allow VBG cord-010092-uftc8inx 9068 15 for for IN cord-010092-uftc8inx 9068 16 the the DT cord-010092-uftc8inx 9068 17 presence presence NN cord-010092-uftc8inx 9068 18 of of IN cord-010092-uftc8inx 9068 19 underlying underlie VBG cord-010092-uftc8inx 9068 20 antibodies antibody NNS cord-010092-uftc8inx 9068 21 to to TO cord-010092-uftc8inx 9068 22 be be VB cord-010092-uftc8inx 9068 23 identified identify VBN cord-010092-uftc8inx 9068 24 . . . cord-010092-uftc8inx 9069 1 In in IN cord-010092-uftc8inx 9069 2 this this DT cord-010092-uftc8inx 9069 3 case case NN cord-010092-uftc8inx 9069 4 , , , cord-010092-uftc8inx 9069 5 underlying underlie VBG cord-010092-uftc8inx 9069 6 antibodies antibody NNS cord-010092-uftc8inx 9069 7 were be VBD cord-010092-uftc8inx 9069 8 not not RB cord-010092-uftc8inx 9069 9 detected detect VBN cord-010092-uftc8inx 9069 10 by by IN cord-010092-uftc8inx 9069 11 using use VBG cord-010092-uftc8inx 9069 12 reagent reagent NN cord-010092-uftc8inx 9069 13 DTT DTT NNP cord-010092-uftc8inx 9069 14 treated treat VBD cord-010092-uftc8inx 9069 15 red red JJ cord-010092-uftc8inx 9069 16 cells cell NNS cord-010092-uftc8inx 9069 17 or or CC cord-010092-uftc8inx 9069 18 phenotyped phenotype VBN cord-010092-uftc8inx 9069 19 cord cord NN cord-010092-uftc8inx 9069 20 cells cell NNS cord-010092-uftc8inx 9069 21 . . . cord-010092-uftc8inx 9070 1 Adsorption adsorption NN cord-010092-uftc8inx 9070 2 technique technique NN cord-010092-uftc8inx 9070 3 was be VBD cord-010092-uftc8inx 9070 4 ineffective ineffective JJ cord-010092-uftc8inx 9070 5 at at IN cord-010092-uftc8inx 9070 6 elimination elimination NN cord-010092-uftc8inx 9070 7 the the DT cord-010092-uftc8inx 9070 8 reactivity reactivity NN cord-010092-uftc8inx 9070 9 . . . cord-010092-uftc8inx 9071 1 Summary Summary NNP cord-010092-uftc8inx 9071 2 / / SYM cord-010092-uftc8inx 9071 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 9071 4 : : : cord-010092-uftc8inx 9072 1 DARA DARA NNP cord-010092-uftc8inx 9072 2 is be VBZ cord-010092-uftc8inx 9072 3 the the DT cord-010092-uftc8inx 9072 4 first first JJ cord-010092-uftc8inx 9072 5 commercial commercial JJ cord-010092-uftc8inx 9072 6 FDA FDA NNP cord-010092-uftc8inx 9072 7 - - HYPH cord-010092-uftc8inx 9072 8 approved approve VBN cord-010092-uftc8inx 9072 9 therapeutic therapeutic JJ cord-010092-uftc8inx 9072 10 monoclonal monoclonal JJ cord-010092-uftc8inx 9072 11 antibody antibody NN cord-010092-uftc8inx 9072 12 used use VBN cord-010092-uftc8inx 9072 13 in in IN cord-010092-uftc8inx 9072 14 treating treat VBG cord-010092-uftc8inx 9072 15 Multiple Multiple NNP cord-010092-uftc8inx 9072 16 Myeloma Myeloma NNP cord-010092-uftc8inx 9072 17 patients patient NNS cord-010092-uftc8inx 9072 18 . . . cord-010092-uftc8inx 9073 1 • • NNP cord-010092-uftc8inx 9074 1 Since since IN cord-010092-uftc8inx 9074 2 CD38 CD38 NNP cord-010092-uftc8inx 9074 3 is be VBZ cord-010092-uftc8inx 9074 4 weakly weakly RB cord-010092-uftc8inx 9074 5 expressed express VBN cord-010092-uftc8inx 9074 6 on on IN cord-010092-uftc8inx 9074 7 normal normal JJ cord-010092-uftc8inx 9074 8 red red JJ cord-010092-uftc8inx 9074 9 blood blood NN cord-010092-uftc8inx 9074 10 cells cell NNS cord-010092-uftc8inx 9074 11 , , , cord-010092-uftc8inx 9074 12 DARA DARA NNP cord-010092-uftc8inx 9074 13 attachment attachment NN cord-010092-uftc8inx 9074 14 to to IN cord-010092-uftc8inx 9074 15 red red JJ cord-010092-uftc8inx 9074 16 blood blood NN cord-010092-uftc8inx 9074 17 cells cell NNS cord-010092-uftc8inx 9074 18 can can MD cord-010092-uftc8inx 9074 19 interfere interfere VB cord-010092-uftc8inx 9074 20 with with IN cord-010092-uftc8inx 9074 21 pre pre JJ cord-010092-uftc8inx 9074 22 - - JJ cord-010092-uftc8inx 9074 23 transfusion transfusion NN cord-010092-uftc8inx 9074 24 IAT IAT NNP cord-010092-uftc8inx 9074 25 testing testing NN cord-010092-uftc8inx 9074 26 . . . cord-010092-uftc8inx 9075 1 • • NNP cord-010092-uftc8inx 9076 1 DTT DTT NNP cord-010092-uftc8inx 9076 2 treatment treatment NN cord-010092-uftc8inx 9076 3 of of IN cord-010092-uftc8inx 9076 4 reagent reagent JJ cord-010092-uftc8inx 9076 5 red red JJ cord-010092-uftc8inx 9076 6 blood blood NN cord-010092-uftc8inx 9076 7 cells cell NNS cord-010092-uftc8inx 9076 8 and and CC cord-010092-uftc8inx 9076 9 cord cord NN cord-010092-uftc8inx 9076 10 cells cell NNS cord-010092-uftc8inx 9076 11 can can MD cord-010092-uftc8inx 9076 12 abolish abolish VB cord-010092-uftc8inx 9076 13 the the DT cord-010092-uftc8inx 9076 14 interference interference NN cord-010092-uftc8inx 9076 15 of of IN cord-010092-uftc8inx 9076 16 DARA DARA NNP cord-010092-uftc8inx 9076 17 to to TO cord-010092-uftc8inx 9076 18 test test VB cord-010092-uftc8inx 9076 19 for for IN cord-010092-uftc8inx 9076 20 the the DT cord-010092-uftc8inx 9076 21 presence presence NN cord-010092-uftc8inx 9076 22 of of IN cord-010092-uftc8inx 9076 23 underlying underlie VBG cord-010092-uftc8inx 9076 24 alloantibodies alloantibody NNS cord-010092-uftc8inx 9076 25 . . . cord-010092-uftc8inx 9077 1 • • NNP cord-010092-uftc8inx 9078 1 To to TO cord-010092-uftc8inx 9078 2 prevent prevent VB cord-010092-uftc8inx 9078 3 delays delay NNS cord-010092-uftc8inx 9078 4 in in IN cord-010092-uftc8inx 9078 5 issuing issue VBG cord-010092-uftc8inx 9078 6 red red JJ cord-010092-uftc8inx 9078 7 blood blood NN cord-010092-uftc8inx 9078 8 cell cell NN cord-010092-uftc8inx 9078 9 units unit NNS cord-010092-uftc8inx 9078 10 to to IN cord-010092-uftc8inx 9078 11 patients patient NNS cord-010092-uftc8inx 9078 12 , , , cord-010092-uftc8inx 9078 13 hospitals hospital NNS cord-010092-uftc8inx 9078 14 should should MD cord-010092-uftc8inx 9078 15 send send VB cord-010092-uftc8inx 9078 16 patient patient JJ cord-010092-uftc8inx 9078 17 samples sample NNS cord-010092-uftc8inx 9078 18 to to TO cord-010092-uftc8inx 9078 19 be be VB cord-010092-uftc8inx 9078 20 tested test VBN cord-010092-uftc8inx 9078 21 before before IN cord-010092-uftc8inx 9078 22 receiving receive VBG cord-010092-uftc8inx 9078 23 DARA DARA NNP cord-010092-uftc8inx 9078 24 treatment treatment NN cord-010092-uftc8inx 9078 25 to to TO cord-010092-uftc8inx 9078 26 ensure ensure VB cord-010092-uftc8inx 9078 27 that that IN cord-010092-uftc8inx 9078 28 clinically clinically RB cord-010092-uftc8inx 9078 29 significant significant JJ cord-010092-uftc8inx 9078 30 alloantibodies alloantibody NNS cord-010092-uftc8inx 9078 31 are be VBP cord-010092-uftc8inx 9078 32 not not RB cord-010092-uftc8inx 9078 33 being be VBG cord-010092-uftc8inx 9078 34 masked mask VBN cord-010092-uftc8inx 9078 35 . . . cord-010092-uftc8inx 9079 1 Background background NN cord-010092-uftc8inx 9079 2 : : : cord-010092-uftc8inx 9080 1 Antibody antibody NN cord-010092-uftc8inx 9080 2 screening screening NN cord-010092-uftc8inx 9080 3 ( ( -LRB- cord-010092-uftc8inx 9080 4 AS)is AS)is NNP cord-010092-uftc8inx 9080 5 considered consider VBN cord-010092-uftc8inx 9080 6 superior superior JJ cord-010092-uftc8inx 9080 7 to to IN cord-010092-uftc8inx 9080 8 antihuman antihuman JJ cord-010092-uftc8inx 9080 9 globulin globulin NN cord-010092-uftc8inx 9081 1 ( ( -LRB- cord-010092-uftc8inx 9081 2 AHG AHG NNP cord-010092-uftc8inx 9081 3 ) ) -RRB- cord-010092-uftc8inx 9081 4 cross cross NN cord-010092-uftc8inx 9081 5 match match NN cord-010092-uftc8inx 9081 6 during during IN cord-010092-uftc8inx 9081 7 pretransfusion pretransfusion NN cord-010092-uftc8inx 9081 8 compatibility compatibility NN cord-010092-uftc8inx 9081 9 testing testing NN cord-010092-uftc8inx 9081 10 . . . cord-010092-uftc8inx 9082 1 In in IN cord-010092-uftc8inx 9082 2 spite spite NN cord-010092-uftc8inx 9082 3 of of IN cord-010092-uftc8inx 9082 4 knowing know VBG cord-010092-uftc8inx 9082 5 the the DT cord-010092-uftc8inx 9082 6 utility utility NN cord-010092-uftc8inx 9082 7 and and CC cord-010092-uftc8inx 9082 8 superiority superiority NN cord-010092-uftc8inx 9082 9 of of IN cord-010092-uftc8inx 9082 10 AS AS NNP cord-010092-uftc8inx 9082 11 , , , cord-010092-uftc8inx 9082 12 it -PRON- PRP cord-010092-uftc8inx 9082 13 has have VBZ cord-010092-uftc8inx 9082 14 not not RB cord-010092-uftc8inx 9082 15 been be VBN cord-010092-uftc8inx 9082 16 adopted adopt VBN cord-010092-uftc8inx 9082 17 uniformly uniformly RB cord-010092-uftc8inx 9082 18 in in IN cord-010092-uftc8inx 9082 19 India India NNP cord-010092-uftc8inx 9082 20 . . . cord-010092-uftc8inx 9083 1 Therefore therefore RB cord-010092-uftc8inx 9083 2 , , , cord-010092-uftc8inx 9083 3 scarce scarce JJ cord-010092-uftc8inx 9083 4 data datum NNS cord-010092-uftc8inx 9083 5 is be VBZ cord-010092-uftc8inx 9083 6 available available JJ cord-010092-uftc8inx 9083 7 from from IN cord-010092-uftc8inx 9083 8 this this DT cord-010092-uftc8inx 9083 9 subcontinent subcontinent NN cord-010092-uftc8inx 9083 10 in in IN cord-010092-uftc8inx 9083 11 terms term NNS cord-010092-uftc8inx 9083 12 of of IN cord-010092-uftc8inx 9083 13 optimisation optimisation NN cord-010092-uftc8inx 9083 14 of of IN cord-010092-uftc8inx 9083 15 red red JJ cord-010092-uftc8inx 9083 16 cell cell NN cord-010092-uftc8inx 9083 17 antibody antibody NN cord-010092-uftc8inx 9083 18 detection detection NN cord-010092-uftc8inx 9083 19 during during IN cord-010092-uftc8inx 9083 20 pretransfusion pretransfusion NN cord-010092-uftc8inx 9083 21 testing testing NN cord-010092-uftc8inx 9083 22 in in IN cord-010092-uftc8inx 9083 23 form form NN cord-010092-uftc8inx 9083 24 of of IN cord-010092-uftc8inx 9083 25 " " `` cord-010092-uftc8inx 9083 26 Type type NN cord-010092-uftc8inx 9083 27 and and CC cord-010092-uftc8inx 9083 28 screen screen NN cord-010092-uftc8inx 9083 29 " " `` cord-010092-uftc8inx 9083 30 Aims aim VBZ cord-010092-uftc8inx 9083 31 : : : cord-010092-uftc8inx 9084 1 The the DT cord-010092-uftc8inx 9084 2 main main JJ cord-010092-uftc8inx 9084 3 objective objective NN cord-010092-uftc8inx 9084 4 was be VBD cord-010092-uftc8inx 9084 5 to to TO cord-010092-uftc8inx 9084 6 study study VB cord-010092-uftc8inx 9084 7 the the DT cord-010092-uftc8inx 9084 8 benefits benefit NNS cord-010092-uftc8inx 9084 9 of of IN cord-010092-uftc8inx 9084 10 performing perform VBG cord-010092-uftc8inx 9084 11 simultaneous simultaneous JJ cord-010092-uftc8inx 9084 12 antibody antibody NN cord-010092-uftc8inx 9084 13 screening screening NN cord-010092-uftc8inx 9084 14 along along IN cord-010092-uftc8inx 9084 15 with with IN cord-010092-uftc8inx 9084 16 the the DT cord-010092-uftc8inx 9084 17 blood blood NN cord-010092-uftc8inx 9084 18 grouping grouping NN cord-010092-uftc8inx 9084 19 during during IN cord-010092-uftc8inx 9084 20 the the DT cord-010092-uftc8inx 9084 21 first first JJ cord-010092-uftc8inx 9084 22 hospital hospital NN cord-010092-uftc8inx 9084 23 visit visit NN cord-010092-uftc8inx 9084 24 to to IN cord-010092-uftc8inx 9084 25 the the DT cord-010092-uftc8inx 9084 26 hospital hospital NN cord-010092-uftc8inx 9084 27 . . . cord-010092-uftc8inx 9085 1 Other other JJ cord-010092-uftc8inx 9085 2 objectives objective NNS cord-010092-uftc8inx 9085 3 were be VBD cord-010092-uftc8inx 9085 4 to to TO cord-010092-uftc8inx 9085 5 study study VB cord-010092-uftc8inx 9085 6 the the DT cord-010092-uftc8inx 9085 7 prevalence prevalence NN cord-010092-uftc8inx 9085 8 of of IN cord-010092-uftc8inx 9085 9 clinically clinically RB cord-010092-uftc8inx 9085 10 significant significant JJ cord-010092-uftc8inx 9085 11 antibody antibody NN cord-010092-uftc8inx 9085 12 among among IN cord-010092-uftc8inx 9085 13 the the DT cord-010092-uftc8inx 9085 14 Indian indian JJ cord-010092-uftc8inx 9085 15 population population NN cord-010092-uftc8inx 9085 16 and and CC cord-010092-uftc8inx 9085 17 to to TO cord-010092-uftc8inx 9085 18 follow follow VB cord-010092-uftc8inx 9085 19 up up RP cord-010092-uftc8inx 9085 20 the the DT cord-010092-uftc8inx 9085 21 patients patient NNS cord-010092-uftc8inx 9085 22 who who WP cord-010092-uftc8inx 9085 23 were be VBD cord-010092-uftc8inx 9085 24 transfused transfuse VBN cord-010092-uftc8inx 9085 25 antibody antibody NN cord-010092-uftc8inx 9085 26 screen screen NN cord-010092-uftc8inx 9085 27 negative negative JJ cord-010092-uftc8inx 9085 28 but but CC cord-010092-uftc8inx 9085 29 cross cross JJ cord-010092-uftc8inx 9085 30 match match VB cord-010092-uftc8inx 9085 31 incompatible incompatible JJ cord-010092-uftc8inx 9085 32 blood blood NN cord-010092-uftc8inx 9085 33 . . . cord-010092-uftc8inx 9086 1 We -PRON- PRP cord-010092-uftc8inx 9086 2 also also RB cord-010092-uftc8inx 9086 3 studied study VBD cord-010092-uftc8inx 9086 4 some some DT cord-010092-uftc8inx 9086 5 other other JJ cord-010092-uftc8inx 9086 6 relevant relevant JJ cord-010092-uftc8inx 9086 7 quality quality NN cord-010092-uftc8inx 9086 8 indicators indicator NNS cord-010092-uftc8inx 9086 9 related relate VBN cord-010092-uftc8inx 9086 10 to to IN cord-010092-uftc8inx 9086 11 efficiency efficiency NN cord-010092-uftc8inx 9086 12 of of IN cord-010092-uftc8inx 9086 13 blood blood NN cord-010092-uftc8inx 9086 14 transfusion transfusion NN cord-010092-uftc8inx 9086 15 services service NNS cord-010092-uftc8inx 9086 16 Methods method NNS cord-010092-uftc8inx 9086 17 : : : cord-010092-uftc8inx 9087 1 This this DT cord-010092-uftc8inx 9087 2 prospective prospective JJ cord-010092-uftc8inx 9087 3 study study NN cord-010092-uftc8inx 9087 4 was be VBD cord-010092-uftc8inx 9087 5 carried carry VBN cord-010092-uftc8inx 9087 6 out out RP cord-010092-uftc8inx 9087 7 at at IN cord-010092-uftc8inx 9087 8 a a DT cord-010092-uftc8inx 9087 9 tertiary tertiary JJ cord-010092-uftc8inx 9087 10 healthcare healthcare NN cord-010092-uftc8inx 9087 11 centre centre NN cord-010092-uftc8inx 9087 12 in in IN cord-010092-uftc8inx 9087 13 India India NNP cord-010092-uftc8inx 9087 14 between between IN cord-010092-uftc8inx 9087 15 July July NNP cord-010092-uftc8inx 9087 16 2014 2014 CD cord-010092-uftc8inx 9087 17 and and CC cord-010092-uftc8inx 9087 18 Dec Dec NNP cord-010092-uftc8inx 9087 19 2018 2018 CD cord-010092-uftc8inx 9087 20 ( ( -LRB- cord-010092-uftc8inx 9087 21 54 54 CD cord-010092-uftc8inx 9087 22 months month NNS cord-010092-uftc8inx 9087 23 ) ) -RRB- cord-010092-uftc8inx 9087 24 . . . cord-010092-uftc8inx 9088 1 The the DT cord-010092-uftc8inx 9088 2 study study NN cord-010092-uftc8inx 9088 3 protocol protocol NN cord-010092-uftc8inx 9088 4 was be VBD cord-010092-uftc8inx 9088 5 submitted submit VBN cord-010092-uftc8inx 9088 6 to to IN cord-010092-uftc8inx 9088 7 institutional institutional JJ cord-010092-uftc8inx 9088 8 review review NNP cord-010092-uftc8inx 9088 9 board board NN cord-010092-uftc8inx 9088 10 and and CC cord-010092-uftc8inx 9088 11 permission permission NN cord-010092-uftc8inx 9088 12 was be VBD cord-010092-uftc8inx 9088 13 granted grant VBN cord-010092-uftc8inx 9088 14 . . . cord-010092-uftc8inx 9089 1 Blood blood NN cord-010092-uftc8inx 9089 2 grouping grouping NN cord-010092-uftc8inx 9089 3 and and CC cord-010092-uftc8inx 9089 4 AS AS NNP cord-010092-uftc8inx 9089 5 were be VBD cord-010092-uftc8inx 9089 6 done do VBN cord-010092-uftc8inx 9089 7 during during IN cord-010092-uftc8inx 9089 8 patients patient NNS cord-010092-uftc8inx 9089 9 ' ' POS cord-010092-uftc8inx 9089 10 first first JJ cord-010092-uftc8inx 9089 11 hospital hospital NN cord-010092-uftc8inx 9089 12 visit visit NN cord-010092-uftc8inx 9089 13 , , , cord-010092-uftc8inx 9089 14 which which WDT cord-010092-uftc8inx 9089 15 we -PRON- PRP cord-010092-uftc8inx 9089 16 called call VBD cord-010092-uftc8inx 9089 17 " " `` cord-010092-uftc8inx 9089 18 type type NN cord-010092-uftc8inx 9089 19 and and CC cord-010092-uftc8inx 9089 20 screen screen NN cord-010092-uftc8inx 9089 21 " " '' cord-010092-uftc8inx 9089 22 . . . cord-010092-uftc8inx 9090 1 When when WRB cord-010092-uftc8inx 9090 2 the the DT cord-010092-uftc8inx 9090 3 patient patient NN cord-010092-uftc8inx 9090 4 got get VBD cord-010092-uftc8inx 9090 5 admitted admit VBN cord-010092-uftc8inx 9090 6 to to IN cord-010092-uftc8inx 9090 7 the the DT cord-010092-uftc8inx 9090 8 hospital hospital NN cord-010092-uftc8inx 9090 9 and and CC cord-010092-uftc8inx 9090 10 required require VBD cord-010092-uftc8inx 9090 11 blood blood NN cord-010092-uftc8inx 9090 12 transfusion transfusion NN cord-010092-uftc8inx 9090 13 , , , cord-010092-uftc8inx 9090 14 a a DT cord-010092-uftc8inx 9090 15 blood blood NN cord-010092-uftc8inx 9090 16 request request NN cord-010092-uftc8inx 9090 17 form form NN cord-010092-uftc8inx 9090 18 was be VBD cord-010092-uftc8inx 9090 19 generated generate VBN cord-010092-uftc8inx 9090 20 by by IN cord-010092-uftc8inx 9090 21 the the DT cord-010092-uftc8inx 9090 22 user user NN cord-010092-uftc8inx 9090 23 and and CC cord-010092-uftc8inx 9090 24 sent send VBN cord-010092-uftc8inx 9090 25 to to IN cord-010092-uftc8inx 9090 26 blood blood NN cord-010092-uftc8inx 9090 27 bank bank NN cord-010092-uftc8inx 9090 28 . . . cord-010092-uftc8inx 9091 1 Depending depend VBG cord-010092-uftc8inx 9091 2 upon upon IN cord-010092-uftc8inx 9091 3 the the DT cord-010092-uftc8inx 9091 4 results result NNS cord-010092-uftc8inx 9091 5 of of IN cord-010092-uftc8inx 9091 6 antibody antibody NN cord-010092-uftc8inx 9091 7 detection detection NN cord-010092-uftc8inx 9091 8 , , , cord-010092-uftc8inx 9091 9 further further JJ cord-010092-uftc8inx 9091 10 course course NN cord-010092-uftc8inx 9091 11 of of IN cord-010092-uftc8inx 9091 12 action action NN cord-010092-uftc8inx 9091 13 was be VBD cord-010092-uftc8inx 9091 14 chosen choose VBN cord-010092-uftc8inx 9091 15 . . . cord-010092-uftc8inx 9092 1 If if IN cord-010092-uftc8inx 9092 2 patient patient NN cord-010092-uftc8inx 9092 3 was be VBD cord-010092-uftc8inx 9092 4 found find VBN cord-010092-uftc8inx 9092 5 to to TO cord-010092-uftc8inx 9092 6 have have VB cord-010092-uftc8inx 9092 7 no no DT cord-010092-uftc8inx 9092 8 antibody antibody NN cord-010092-uftc8inx 9092 9 , , , cord-010092-uftc8inx 9092 10 immediate immediate JJ cord-010092-uftc8inx 9092 11 spin spin NN cord-010092-uftc8inx 9092 12 test test NN cord-010092-uftc8inx 9093 1 ( ( -LRB- cord-010092-uftc8inx 9093 2 IST IST NNP cord-010092-uftc8inx 9093 3 ) ) -RRB- cord-010092-uftc8inx 9093 4 cross cross NN cord-010092-uftc8inx 9093 5 match match VB cord-010092-uftc8inx 9093 6 compatible compatible JJ cord-010092-uftc8inx 9093 7 blood blood NN cord-010092-uftc8inx 9093 8 was be VBD cord-010092-uftc8inx 9093 9 issued issue VBN cord-010092-uftc8inx 9093 10 and and CC cord-010092-uftc8inx 9093 11 transfused transfuse VBN cord-010092-uftc8inx 9093 12 . . . cord-010092-uftc8inx 9094 1 In in IN cord-010092-uftc8inx 9094 2 such such JJ cord-010092-uftc8inx 9094 3 cases case NNS cord-010092-uftc8inx 9094 4 the the DT cord-010092-uftc8inx 9094 5 procedure procedure NN cord-010092-uftc8inx 9094 6 of of IN cord-010092-uftc8inx 9094 7 AHG AHG NNP cord-010092-uftc8inx 9094 8 crossmatch crossmatch NN cord-010092-uftc8inx 9094 9 testing testing NN cord-010092-uftc8inx 9094 10 was be VBD cord-010092-uftc8inx 9094 11 continued continue VBN cord-010092-uftc8inx 9094 12 even even RB cord-010092-uftc8inx 9094 13 after after IN cord-010092-uftc8inx 9094 14 issue issue NN cord-010092-uftc8inx 9094 15 of of IN cord-010092-uftc8inx 9094 16 blood blood NN cord-010092-uftc8inx 9094 17 . . . cord-010092-uftc8inx 9095 1 Cases case NNS cord-010092-uftc8inx 9095 2 where where WRB cord-010092-uftc8inx 9095 3 AHG AHG NNP cord-010092-uftc8inx 9095 4 cross cross NN cord-010092-uftc8inx 9095 5 match match NN cord-010092-uftc8inx 9095 6 test test NN cord-010092-uftc8inx 9095 7 was be VBD cord-010092-uftc8inx 9095 8 found find VBN cord-010092-uftc8inx 9095 9 negative negative JJ cord-010092-uftc8inx 9095 10 no no DT cord-010092-uftc8inx 9095 11 further further JJ cord-010092-uftc8inx 9095 12 follow follow NN cord-010092-uftc8inx 9095 13 - - HYPH cord-010092-uftc8inx 9095 14 up up NN cord-010092-uftc8inx 9095 15 of of IN cord-010092-uftc8inx 9095 16 the the DT cord-010092-uftc8inx 9095 17 patient patient NN cord-010092-uftc8inx 9095 18 was be VBD cord-010092-uftc8inx 9095 19 done do VBN cord-010092-uftc8inx 9095 20 whereas whereas IN cord-010092-uftc8inx 9095 21 when when WRB cord-010092-uftc8inx 9095 22 AHG AHG NNP cord-010092-uftc8inx 9095 23 cross cross NN cord-010092-uftc8inx 9095 24 match match NN cord-010092-uftc8inx 9095 25 was be VBD cord-010092-uftc8inx 9095 26 found find VBN cord-010092-uftc8inx 9095 27 positive positive JJ cord-010092-uftc8inx 9095 28 , , , cord-010092-uftc8inx 9095 29 patients patient NNS cord-010092-uftc8inx 9095 30 were be VBD cord-010092-uftc8inx 9095 31 followed follow VBN cord-010092-uftc8inx 9095 32 after after IN cord-010092-uftc8inx 9095 33 the the DT cord-010092-uftc8inx 9095 34 transfusion transfusion NN cord-010092-uftc8inx 9095 35 Results result NNS cord-010092-uftc8inx 9095 36 : : : cord-010092-uftc8inx 9095 37 A a DT cord-010092-uftc8inx 9095 38 total total NN cord-010092-uftc8inx 9095 39 of of IN cord-010092-uftc8inx 9095 40 22888 22888 CD cord-010092-uftc8inx 9095 41 patients patient NNS cord-010092-uftc8inx 9095 42 were be VBD cord-010092-uftc8inx 9095 43 " " `` cord-010092-uftc8inx 9095 44 type type NN cord-010092-uftc8inx 9095 45 and and CC cord-010092-uftc8inx 9095 46 screened screen VBN cord-010092-uftc8inx 9095 47 " " '' cord-010092-uftc8inx 9095 48 . . . cord-010092-uftc8inx 9096 1 Majority majority NN cord-010092-uftc8inx 9096 2 were be VBD cord-010092-uftc8inx 9096 3 from from IN cord-010092-uftc8inx 9096 4 hemato hemato NNP cord-010092-uftc8inx 9096 5 - - HYPH cord-010092-uftc8inx 9096 6 oncology oncology NN cord-010092-uftc8inx 9096 7 , , , cord-010092-uftc8inx 9096 8 BMT BMT NNP cord-010092-uftc8inx 9096 9 , , , cord-010092-uftc8inx 9096 10 liver liver NN cord-010092-uftc8inx 9096 11 transplant transplant NN cord-010092-uftc8inx 9096 12 , , , cord-010092-uftc8inx 9096 13 paediatric paediatric JJ cord-010092-uftc8inx 9096 14 cardiac cardiac NN cord-010092-uftc8inx 9096 15 surgery surgery NN cord-010092-uftc8inx 9096 16 , , , cord-010092-uftc8inx 9096 17 and and CC cord-010092-uftc8inx 9096 18 medical medical JJ cord-010092-uftc8inx 9096 19 ICU ICU NNP cord-010092-uftc8inx 9096 20 units unit NNS cord-010092-uftc8inx 9096 21 . . . cord-010092-uftc8inx 9097 1 Clinically clinically RB cord-010092-uftc8inx 9097 2 significant significant JJ cord-010092-uftc8inx 9097 3 allo allo NN cord-010092-uftc8inx 9097 4 - - HYPH cord-010092-uftc8inx 9097 5 antibody antibody NN cord-010092-uftc8inx 9097 6 was be VBD cord-010092-uftc8inx 9097 7 detected detect VBN cord-010092-uftc8inx 9097 8 in in IN cord-010092-uftc8inx 9097 9 145 145 CD cord-010092-uftc8inx 9097 10 patients patient NNS cord-010092-uftc8inx 9097 11 and and CC cord-010092-uftc8inx 9097 12 autoantibody autoantibody NNP cord-010092-uftc8inx 9097 13 was be VBD cord-010092-uftc8inx 9097 14 detected detect VBN cord-010092-uftc8inx 9097 15 in in IN cord-010092-uftc8inx 9097 16 53 53 CD cord-010092-uftc8inx 9097 17 patients patient NNS cord-010092-uftc8inx 9097 18 . . . cord-010092-uftc8inx 9098 1 Alloantibody Alloantibody NNP cord-010092-uftc8inx 9098 2 was be VBD cord-010092-uftc8inx 9098 3 detected detect VBN cord-010092-uftc8inx 9098 4 mainly mainly RB cord-010092-uftc8inx 9098 5 against against IN cord-010092-uftc8inx 9098 6 Rh Rh NNP cord-010092-uftc8inx 9098 7 and and CC cord-010092-uftc8inx 9098 8 Kell Kell NNP cord-010092-uftc8inx 9098 9 blood blood NN cord-010092-uftc8inx 9098 10 group group NN cord-010092-uftc8inx 9098 11 systems system NNS cord-010092-uftc8inx 9098 12 . . . cord-010092-uftc8inx 9099 1 In in IN cord-010092-uftc8inx 9099 2 diagnosed diagnosed JJ cord-010092-uftc8inx 9099 3 AIHA AIHA NNP cord-010092-uftc8inx 9099 4 cases case NNS cord-010092-uftc8inx 9099 5 , , , cord-010092-uftc8inx 9099 6 majority majority NN cord-010092-uftc8inx 9099 7 were be VBD cord-010092-uftc8inx 9099 8 in in IN cord-010092-uftc8inx 9099 9 the the DT cord-010092-uftc8inx 9099 10 form form NN cord-010092-uftc8inx 9099 11 of of IN cord-010092-uftc8inx 9099 12 Warm warm JJ cord-010092-uftc8inx 9099 13 AIHA AIHA NNP cord-010092-uftc8inx 9099 14 ( ( -LRB- cord-010092-uftc8inx 9099 15 58 58 CD cord-010092-uftc8inx 9099 16 % % NN cord-010092-uftc8inx 9099 17 ) ) -RRB- cord-010092-uftc8inx 9099 18 and and CC cord-010092-uftc8inx 9099 19 20 20 CD cord-010092-uftc8inx 9099 20 % % NN cord-010092-uftc8inx 9099 21 of of IN cord-010092-uftc8inx 9099 22 AIHA AIHA NNP cord-010092-uftc8inx 9099 23 cases case NNS cord-010092-uftc8inx 9099 24 were be VBD cord-010092-uftc8inx 9099 25 having have VBG cord-010092-uftc8inx 9099 26 hidden hide VBN cord-010092-uftc8inx 9099 27 single single JJ cord-010092-uftc8inx 9099 28 or or CC cord-010092-uftc8inx 9099 29 multiple multiple JJ cord-010092-uftc8inx 9099 30 alloantibody alloantibody NN cord-010092-uftc8inx 9099 31 . . . cord-010092-uftc8inx 9100 1 Significantly significantly RB cord-010092-uftc8inx 9100 2 higher high JJR cord-010092-uftc8inx 9100 3 proportion proportion NN cord-010092-uftc8inx 9100 4 of of IN cord-010092-uftc8inx 9100 5 patients patient NNS cord-010092-uftc8inx 9100 6 in in IN cord-010092-uftc8inx 9100 7 AS as DT cord-010092-uftc8inx 9100 8 positive positive JJ cord-010092-uftc8inx 9100 9 group group NN cord-010092-uftc8inx 9100 10 required require VBD cord-010092-uftc8inx 9100 11 blood blood NN cord-010092-uftc8inx 9100 12 transfusion transfusion NN cord-010092-uftc8inx 9100 13 than than IN cord-010092-uftc8inx 9100 14 AS as DT cord-010092-uftc8inx 9100 15 negative negative JJ cord-010092-uftc8inx 9100 16 group group NN cord-010092-uftc8inx 9100 17 ( ( -LRB- cord-010092-uftc8inx 9100 18 45 45 CD cord-010092-uftc8inx 9100 19 % % NN cord-010092-uftc8inx 9100 20 VS VS NNP cord-010092-uftc8inx 9100 21 34 34 CD cord-010092-uftc8inx 9100 22 % % NN cord-010092-uftc8inx 9100 23 , , , cord-010092-uftc8inx 9100 24 P p NN cord-010092-uftc8inx 9100 25 < < XX cord-010092-uftc8inx 9100 26 0.05 0.05 CD cord-010092-uftc8inx 9100 27 ) ) -RRB- cord-010092-uftc8inx 9100 28 . . . cord-010092-uftc8inx 9101 1 in in IN cord-010092-uftc8inx 9101 2 both both CC cord-010092-uftc8inx 9101 3 the the DT cord-010092-uftc8inx 9101 4 groups group NNS cord-010092-uftc8inx 9101 5 , , , cord-010092-uftc8inx 9101 6 in in IN cord-010092-uftc8inx 9101 7 planned plan VBN cord-010092-uftc8inx 9101 8 cases case NNS cord-010092-uftc8inx 9101 9 , , , cord-010092-uftc8inx 9101 10 most most JJS cord-010092-uftc8inx 9101 11 of of IN cord-010092-uftc8inx 9101 12 the the DT cord-010092-uftc8inx 9101 13 time time NN cord-010092-uftc8inx 9101 14 blood blood NN cord-010092-uftc8inx 9101 15 was be VBD cord-010092-uftc8inx 9101 16 issued issue VBN cord-010092-uftc8inx 9101 17 immediately immediately RB cord-010092-uftc8inx 9101 18 within within IN cord-010092-uftc8inx 9101 19 the the DT cord-010092-uftc8inx 9101 20 defined define VBN cord-010092-uftc8inx 9101 21 turnaround turnaround NN cord-010092-uftc8inx 9101 22 time time NN cord-010092-uftc8inx 9101 23 except except IN cord-010092-uftc8inx 9101 24 in in IN cord-010092-uftc8inx 9101 25 21 21 CD cord-010092-uftc8inx 9101 26 where where WRB cord-010092-uftc8inx 9101 27 either either DT cord-010092-uftc8inx 9101 28 transfusion transfusion NN cord-010092-uftc8inx 9101 29 was be VBD cord-010092-uftc8inx 9101 30 delayed delay VBN cord-010092-uftc8inx 9101 31 or or CC cord-010092-uftc8inx 9101 32 surgery surgery NN cord-010092-uftc8inx 9101 33 was be VBD cord-010092-uftc8inx 9101 34 postponed postpone VBN cord-010092-uftc8inx 9101 35 . . . cord-010092-uftc8inx 9102 1 It -PRON- PRP cord-010092-uftc8inx 9102 2 happened happen VBD cord-010092-uftc8inx 9102 3 only only RB cord-010092-uftc8inx 9102 4 in in IN cord-010092-uftc8inx 9102 5 trauma trauma NN cord-010092-uftc8inx 9102 6 or or CC cord-010092-uftc8inx 9102 7 surgical surgical JJ cord-010092-uftc8inx 9102 8 bleed bleed NN cord-010092-uftc8inx 9102 9 cases case NNS cord-010092-uftc8inx 9102 10 . . . cord-010092-uftc8inx 9103 1 Expiry expiry NN cord-010092-uftc8inx 9103 2 of of IN cord-010092-uftc8inx 9103 3 blood blood NN cord-010092-uftc8inx 9103 4 was be VBD cord-010092-uftc8inx 9103 5 decreased decrease VBN cord-010092-uftc8inx 9103 6 significantly significantly RB cord-010092-uftc8inx 9103 7 due due JJ cord-010092-uftc8inx 9103 8 to to IN cord-010092-uftc8inx 9103 9 no no DT cord-010092-uftc8inx 9103 10 usage usage NN cord-010092-uftc8inx 9103 11 of of IN cord-010092-uftc8inx 9103 12 blood blood NN cord-010092-uftc8inx 9103 13 ( ( -LRB- cord-010092-uftc8inx 9103 14 1.2 1.2 CD cord-010092-uftc8inx 9103 15 % % NN cord-010092-uftc8inx 9103 16 vs. vs. IN cord-010092-uftc8inx 9103 17 5 5 CD cord-010092-uftc8inx 9103 18 % % NN cord-010092-uftc8inx 9103 19 , , , cord-010092-uftc8inx 9103 20 P p NN cord-010092-uftc8inx 9103 21 < < XX cord-010092-uftc8inx 9103 22 0.05 0.05 CD cord-010092-uftc8inx 9103 23 ) ) -RRB- cord-010092-uftc8inx 9103 24 . . . cord-010092-uftc8inx 9104 1 During during IN cord-010092-uftc8inx 9104 2 the the DT cord-010092-uftc8inx 9104 3 period period NN cord-010092-uftc8inx 9104 4 of of IN cord-010092-uftc8inx 9104 5 study study NN cord-010092-uftc8inx 9104 6 we -PRON- PRP cord-010092-uftc8inx 9104 7 obtained obtain VBD cord-010092-uftc8inx 9104 8 10 10 CD cord-010092-uftc8inx 9104 9 cases case NNS cord-010092-uftc8inx 9104 10 where where WRB cord-010092-uftc8inx 9104 11 the the DT cord-010092-uftc8inx 9104 12 IST IST NNP cord-010092-uftc8inx 9104 13 cross cross NN cord-010092-uftc8inx 9104 14 match match NN cord-010092-uftc8inx 9104 15 was be VBD cord-010092-uftc8inx 9104 16 compatible compatible JJ cord-010092-uftc8inx 9104 17 but but CC cord-010092-uftc8inx 9104 18 the the DT cord-010092-uftc8inx 9104 19 AHG AHG NNP cord-010092-uftc8inx 9104 20 cross cross NN cord-010092-uftc8inx 9104 21 match match NN cord-010092-uftc8inx 9104 22 was be VBD cord-010092-uftc8inx 9104 23 incompatible incompatible JJ cord-010092-uftc8inx 9104 24 . . . cord-010092-uftc8inx 9105 1 During during IN cord-010092-uftc8inx 9105 2 follow follow VB cord-010092-uftc8inx 9105 3 up up RP cord-010092-uftc8inx 9105 4 none none NN cord-010092-uftc8inx 9105 5 of of IN cord-010092-uftc8inx 9105 6 the the DT cord-010092-uftc8inx 9105 7 cases case NNS cord-010092-uftc8inx 9105 8 demonstrated demonstrate VBD cord-010092-uftc8inx 9105 9 any any DT cord-010092-uftc8inx 9105 10 sign sign NN cord-010092-uftc8inx 9105 11 of of IN cord-010092-uftc8inx 9105 12 hemolysis hemolysis NN cord-010092-uftc8inx 9105 13 Summary Summary NNP cord-010092-uftc8inx 9105 14 / / SYM cord-010092-uftc8inx 9105 15 Conclusions Conclusions NNPS cord-010092-uftc8inx 9105 16 : : : cord-010092-uftc8inx 9106 1 In in IN cord-010092-uftc8inx 9106 2 developing develop VBG cord-010092-uftc8inx 9106 3 countries country NNS cord-010092-uftc8inx 9106 4 like like IN cord-010092-uftc8inx 9106 5 us -PRON- PRP cord-010092-uftc8inx 9106 6 , , , cord-010092-uftc8inx 9106 7 optimization optimization NN cord-010092-uftc8inx 9106 8 of of IN cord-010092-uftc8inx 9106 9 AS AS NNP cord-010092-uftc8inx 9106 10 during during IN cord-010092-uftc8inx 9106 11 pretransfusion pretransfusion NN cord-010092-uftc8inx 9106 12 testing testing NN cord-010092-uftc8inx 9106 13 increases increase VBZ cord-010092-uftc8inx 9106 14 operational operational JJ cord-010092-uftc8inx 9106 15 efficiency efficiency NN cord-010092-uftc8inx 9106 16 and and CC cord-010092-uftc8inx 9106 17 significantly significantly RB cord-010092-uftc8inx 9106 18 decreases decrease VBZ cord-010092-uftc8inx 9106 19 the the DT cord-010092-uftc8inx 9106 20 expiry expiry NN cord-010092-uftc8inx 9106 21 of of IN cord-010092-uftc8inx 9106 22 blood blood NN cord-010092-uftc8inx 9106 23 . . . cord-010092-uftc8inx 9107 1 Results result NNS cord-010092-uftc8inx 9107 2 : : : cord-010092-uftc8inx 9108 1 During during IN cord-010092-uftc8inx 9108 2 the the DT cord-010092-uftc8inx 9108 3 period period NN cord-010092-uftc8inx 9108 4 when when WRB cord-010092-uftc8inx 9108 5 AbSc AbSc NNP cord-010092-uftc8inx 9108 6 was be VBD cord-010092-uftc8inx 9108 7 performed perform VBN cord-010092-uftc8inx 9108 8 on on IN cord-010092-uftc8inx 9108 9 PK7300 PK7300 NNP cord-010092-uftc8inx 9108 10 , , , cord-010092-uftc8inx 9108 11 250,599 250,599 CD cord-010092-uftc8inx 9108 12 donation donation NN cord-010092-uftc8inx 9108 13 samples sample NNS cord-010092-uftc8inx 9108 14 were be VBD cord-010092-uftc8inx 9108 15 tested test VBN cord-010092-uftc8inx 9108 16 and and CC cord-010092-uftc8inx 9108 17 4,895 4,895 CD cord-010092-uftc8inx 9108 18 ( ( -LRB- cord-010092-uftc8inx 9108 19 1.95 1.95 CD cord-010092-uftc8inx 9108 20 % % NN cord-010092-uftc8inx 9108 21 ) ) -RRB- cord-010092-uftc8inx 9108 22 were be VBD cord-010092-uftc8inx 9108 23 found find VBN cord-010092-uftc8inx 9108 24 AbSc absc JJ cord-010092-uftc8inx 9108 25 positive positive JJ cord-010092-uftc8inx 9108 26 . . . cord-010092-uftc8inx 9109 1 Antibodies antibody NNS cord-010092-uftc8inx 9109 2 to to IN cord-010092-uftc8inx 9109 3 red red JJ cord-010092-uftc8inx 9109 4 cells cell NNS cord-010092-uftc8inx 9109 5 were be VBD cord-010092-uftc8inx 9109 6 identified identify VBN cord-010092-uftc8inx 9109 7 in in IN cord-010092-uftc8inx 9109 8 250 250 CD cord-010092-uftc8inx 9109 9 donations donation NNS cord-010092-uftc8inx 9109 10 out out IN cord-010092-uftc8inx 9109 11 of of IN cord-010092-uftc8inx 9109 12 4,895 4,895 CD cord-010092-uftc8inx 9109 13 ( ( -LRB- cord-010092-uftc8inx 9109 14 5.11 5.11 CD cord-010092-uftc8inx 9109 15 % % NN cord-010092-uftc8inx 9109 16 ) ) -RRB- cord-010092-uftc8inx 9110 1 AbSc absc JJ cord-010092-uftc8inx 9110 2 positive positive JJ cord-010092-uftc8inx 9110 3 samples sample NNS cord-010092-uftc8inx 9110 4 and and CC cord-010092-uftc8inx 9110 5 in in IN cord-010092-uftc8inx 9110 6 the the DT cord-010092-uftc8inx 9110 7 rest rest NN cord-010092-uftc8inx 9110 8 , , , cord-010092-uftc8inx 9110 9 no no DT cord-010092-uftc8inx 9110 10 irregular irregular JJ cord-010092-uftc8inx 9110 11 antibodies antibody NNS cord-010092-uftc8inx 9110 12 were be VBD cord-010092-uftc8inx 9110 13 detected detect VBN cord-010092-uftc8inx 9110 14 . . . cord-010092-uftc8inx 9111 1 The the DT cord-010092-uftc8inx 9111 2 prevalence prevalence NN cord-010092-uftc8inx 9111 3 rate rate NN cord-010092-uftc8inx 9111 4 for for IN cord-010092-uftc8inx 9111 5 atypical atypical JJ cord-010092-uftc8inx 9111 6 antibody antibody NN cord-010092-uftc8inx 9111 7 was be VBD cord-010092-uftc8inx 9111 8 0.10 0.10 CD cord-010092-uftc8inx 9111 9 % % NN cord-010092-uftc8inx 9111 10 . . . cord-010092-uftc8inx 9112 1 The the DT cord-010092-uftc8inx 9112 2 top top JJ cord-010092-uftc8inx 9112 3 5 5 CD cord-010092-uftc8inx 9112 4 most most RBS cord-010092-uftc8inx 9112 5 frequent frequent JJ cord-010092-uftc8inx 9112 6 antibody antibody NN cord-010092-uftc8inx 9112 7 specificities specificity NNS cord-010092-uftc8inx 9112 8 were be VBD cord-010092-uftc8inx 9112 9 : : : cord-010092-uftc8inx 9112 10 nonspecific nonspecific JJ cord-010092-uftc8inx 9112 11 cold cold JJ cord-010092-uftc8inx 9112 12 antibodies antibody NNS cord-010092-uftc8inx 9112 13 ( ( -LRB- cord-010092-uftc8inx 9112 14 28.8 28.8 CD cord-010092-uftc8inx 9112 15 % % NN cord-010092-uftc8inx 9112 16 ) ) -RRB- cord-010092-uftc8inx 9112 17 , , , cord-010092-uftc8inx 9112 18 anti anti JJ cord-010092-uftc8inx 9112 19 - - JJ cord-010092-uftc8inx 9112 20 E e JJ cord-010092-uftc8inx 9112 21 ( ( -LRB- cord-010092-uftc8inx 9112 22 26.8 26.8 CD cord-010092-uftc8inx 9112 23 % % NN cord-010092-uftc8inx 9112 24 ) ) -RRB- cord-010092-uftc8inx 9112 25 , , , cord-010092-uftc8inx 9112 26 anti anti NNP cord-010092-uftc8inx 9112 27 - - NNP cord-010092-uftc8inx 9112 28 Mi Mi NNP cord-010092-uftc8inx 9112 29 a a DT cord-010092-uftc8inx 9112 30 ( ( -LRB- cord-010092-uftc8inx 9112 31 19.6 19.6 CD cord-010092-uftc8inx 9112 32 % % NN cord-010092-uftc8inx 9112 33 ) ) -RRB- cord-010092-uftc8inx 9112 34 , , , cord-010092-uftc8inx 9112 35 anti anti NNP cord-010092-uftc8inx 9112 36 - - NNP cord-010092-uftc8inx 9112 37 M m JJ cord-010092-uftc8inx 9112 38 ( ( -LRB- cord-010092-uftc8inx 9112 39 16.8 16.8 CD cord-010092-uftc8inx 9112 40 % % NN cord-010092-uftc8inx 9112 41 ) ) -RRB- cord-010092-uftc8inx 9112 42 and and CC cord-010092-uftc8inx 9112 43 anti anti JJ cord-010092-uftc8inx 9112 44 - - NNP cord-010092-uftc8inx 9112 45 Le Le NNP cord-010092-uftc8inx 9112 46 a a NN cord-010092-uftc8inx 9112 47 ( ( -LRB- cord-010092-uftc8inx 9112 48 4.0 4.0 CD cord-010092-uftc8inx 9112 49 % % NN cord-010092-uftc8inx 9112 50 ) ) -RRB- cord-010092-uftc8inx 9112 51 . . . cord-010092-uftc8inx 9113 1 A a DT cord-010092-uftc8inx 9113 2 total total NN cord-010092-uftc8inx 9113 3 of of IN cord-010092-uftc8inx 9113 4 225,124 225,124 CD cord-010092-uftc8inx 9113 5 donations donation NNS cord-010092-uftc8inx 9113 6 were be VBD cord-010092-uftc8inx 9113 7 screened screen VBN cord-010092-uftc8inx 9113 8 for for IN cord-010092-uftc8inx 9113 9 atypical atypical JJ cord-010092-uftc8inx 9113 10 antibodies antibody NNS cord-010092-uftc8inx 9113 11 by by IN cord-010092-uftc8inx 9113 12 IH-1000 ih-1000 NN cord-010092-uftc8inx 9113 13 and and CC cord-010092-uftc8inx 9113 14 2,275 2,275 CD cord-010092-uftc8inx 9113 15 ( ( -LRB- cord-010092-uftc8inx 9113 16 1.01 1.01 CD cord-010092-uftc8inx 9113 17 % % NN cord-010092-uftc8inx 9113 18 ) ) -RRB- cord-010092-uftc8inx 9113 19 were be VBD cord-010092-uftc8inx 9113 20 screened screen VBN cord-010092-uftc8inx 9113 21 positive positive JJ cord-010092-uftc8inx 9113 22 . . . cord-010092-uftc8inx 9114 1 Among among IN cord-010092-uftc8inx 9114 2 these these DT cord-010092-uftc8inx 9114 3 , , , cord-010092-uftc8inx 9114 4 anti anti JJ cord-010092-uftc8inx 9114 5 - - JJ cord-010092-uftc8inx 9114 6 red red JJ cord-010092-uftc8inx 9114 7 cell cell NN cord-010092-uftc8inx 9114 8 antibodies antibody NNS cord-010092-uftc8inx 9114 9 were be VBD cord-010092-uftc8inx 9114 10 identified identify VBN cord-010092-uftc8inx 9114 11 in in IN cord-010092-uftc8inx 9114 12 1,239 1,239 CD cord-010092-uftc8inx 9114 13 samples sample NNS cord-010092-uftc8inx 9114 14 ( ( -LRB- cord-010092-uftc8inx 9114 15 54.46 54.46 CD cord-010092-uftc8inx 9114 16 % % NN cord-010092-uftc8inx 9114 17 ) ) -RRB- cord-010092-uftc8inx 9114 18 , , , cord-010092-uftc8inx 9114 19 which which WDT cord-010092-uftc8inx 9114 20 was be VBD cord-010092-uftc8inx 9114 21 significantly significantly RB cord-010092-uftc8inx 9114 22 higher high JJR cord-010092-uftc8inx 9114 23 than than IN cord-010092-uftc8inx 9114 24 those those DT cord-010092-uftc8inx 9114 25 identified identify VBN cord-010092-uftc8inx 9114 26 in in IN cord-010092-uftc8inx 9114 27 PK7300 PK7300 NNP cord-010092-uftc8inx 9114 28 screened screen VBD cord-010092-uftc8inx 9114 29 positive positive JJ cord-010092-uftc8inx 9114 30 samples sample NNS cord-010092-uftc8inx 9114 31 ( ( -LRB- cord-010092-uftc8inx 9114 32 P p NN cord-010092-uftc8inx 9114 33 < < XX cord-010092-uftc8inx 9114 34 0.00001 0.00001 CD cord-010092-uftc8inx 9114 35 ) ) -RRB- cord-010092-uftc8inx 9114 36 . . . cord-010092-uftc8inx 9115 1 The the DT cord-010092-uftc8inx 9115 2 prevalence prevalence NN cord-010092-uftc8inx 9115 3 rate rate NN cord-010092-uftc8inx 9115 4 for for IN cord-010092-uftc8inx 9115 5 atypical atypical JJ cord-010092-uftc8inx 9115 6 antibody antibody NN cord-010092-uftc8inx 9115 7 as as IN cord-010092-uftc8inx 9115 8 screened screen VBN cord-010092-uftc8inx 9115 9 positive positive JJ cord-010092-uftc8inx 9115 10 by by IN cord-010092-uftc8inx 9115 11 IH-1000 ih-1000 NN cord-010092-uftc8inx 9115 12 and and CC cord-010092-uftc8inx 9115 13 with with IN cord-010092-uftc8inx 9115 14 confirmed confirm VBN cord-010092-uftc8inx 9115 15 red red JJ cord-010092-uftc8inx 9115 16 cell cell NN cord-010092-uftc8inx 9115 17 specificities specificity NNS cord-010092-uftc8inx 9115 18 was be VBD cord-010092-uftc8inx 9115 19 0.55 0.55 CD cord-010092-uftc8inx 9115 20 % % NN cord-010092-uftc8inx 9115 21 , , , cord-010092-uftc8inx 9115 22 which which WDT cord-010092-uftc8inx 9115 23 was be VBD cord-010092-uftc8inx 9115 24 also also RB cord-010092-uftc8inx 9115 25 significantly significantly RB cord-010092-uftc8inx 9115 26 higher high JJR cord-010092-uftc8inx 9115 27 ( ( -LRB- cord-010092-uftc8inx 9115 28 P p NN cord-010092-uftc8inx 9115 29 < < XX cord-010092-uftc8inx 9115 30 0.00001 0.00001 CD cord-010092-uftc8inx 9115 31 ) ) -RRB- cord-010092-uftc8inx 9115 32 . . . cord-010092-uftc8inx 9116 1 The the DT cord-010092-uftc8inx 9116 2 top top JJ cord-010092-uftc8inx 9116 3 5 5 CD cord-010092-uftc8inx 9116 4 most most RBS cord-010092-uftc8inx 9116 5 frequent frequent JJ cord-010092-uftc8inx 9116 6 antibody antibody NN cord-010092-uftc8inx 9116 7 specificities specificity NNS cord-010092-uftc8inx 9116 8 were be VBD cord-010092-uftc8inx 9116 9 : : : cord-010092-uftc8inx 9116 10 anti anti NNP cord-010092-uftc8inx 9116 11 - - NNP cord-010092-uftc8inx 9116 12 Mi Mi NNP cord-010092-uftc8inx 9116 13 a a DT cord-010092-uftc8inx 9116 14 ( ( -LRB- cord-010092-uftc8inx 9116 15 55.3 55.3 CD cord-010092-uftc8inx 9116 16 % % NN cord-010092-uftc8inx 9116 17 ) ) -RRB- cord-010092-uftc8inx 9116 18 , , , cord-010092-uftc8inx 9116 19 anti anti NNP cord-010092-uftc8inx 9116 20 - - NNP cord-010092-uftc8inx 9116 21 M m JJ cord-010092-uftc8inx 9116 22 ( ( -LRB- cord-010092-uftc8inx 9116 23 21.1 21.1 CD cord-010092-uftc8inx 9116 24 % % NN cord-010092-uftc8inx 9116 25 ) ) -RRB- cord-010092-uftc8inx 9116 26 , , , cord-010092-uftc8inx 9116 27 anti anti NNP cord-010092-uftc8inx 9116 28 - - NNP cord-010092-uftc8inx 9116 29 Le Le NNP cord-010092-uftc8inx 9116 30 a a NN cord-010092-uftc8inx 9116 31 ( ( -LRB- cord-010092-uftc8inx 9116 32 10.2 10.2 CD cord-010092-uftc8inx 9116 33 % % NN cord-010092-uftc8inx 9116 34 ) ) -RRB- cord-010092-uftc8inx 9116 35 , , , cord-010092-uftc8inx 9116 36 anti anti JJ cord-010092-uftc8inx 9116 37 - - JJ cord-010092-uftc8inx 9116 38 E e JJ cord-010092-uftc8inx 9116 39 ( ( -LRB- cord-010092-uftc8inx 9116 40 6.5 6.5 CD cord-010092-uftc8inx 9116 41 % % NN cord-010092-uftc8inx 9116 42 ) ) -RRB- cord-010092-uftc8inx 9116 43 and and CC cord-010092-uftc8inx 9116 44 non non JJ cord-010092-uftc8inx 9116 45 - - JJ cord-010092-uftc8inx 9116 46 specific specific JJ cord-010092-uftc8inx 9116 47 cold cold JJ cord-010092-uftc8inx 9116 48 antibodies antibody NNS cord-010092-uftc8inx 9116 49 ( ( -LRB- cord-010092-uftc8inx 9116 50 3.6 3.6 CD cord-010092-uftc8inx 9116 51 % % NN cord-010092-uftc8inx 9116 52 ) ) -RRB- cord-010092-uftc8inx 9116 53 . . . cord-010092-uftc8inx 9117 1 Anti Anti NNP cord-010092-uftc8inx 9117 2 - - NNP cord-010092-uftc8inx 9117 3 Fy Fy NNP cord-010092-uftc8inx 9117 4 b b NNP cord-010092-uftc8inx 9117 5 was be VBD cord-010092-uftc8inx 9117 6 detected detect VBN cord-010092-uftc8inx 9117 7 in in IN cord-010092-uftc8inx 9117 8 7 7 CD cord-010092-uftc8inx 9117 9 cases case NNS cord-010092-uftc8inx 9117 10 , , , cord-010092-uftc8inx 9117 11 which which WDT cord-010092-uftc8inx 9117 12 would would MD cord-010092-uftc8inx 9117 13 be be VB cord-010092-uftc8inx 9117 14 missed miss VBN cord-010092-uftc8inx 9117 15 detection detection NN cord-010092-uftc8inx 9117 16 by by IN cord-010092-uftc8inx 9117 17 enzyme enzyme NN cord-010092-uftc8inx 9117 18 treated treat VBN cord-010092-uftc8inx 9117 19 reagent reagent NN cord-010092-uftc8inx 9117 20 cells cell NNS cord-010092-uftc8inx 9117 21 on on IN cord-010092-uftc8inx 9117 22 PK7300 PK7300 NNP cord-010092-uftc8inx 9117 23 system system NN cord-010092-uftc8inx 9117 24 . . . cord-010092-uftc8inx 9118 1 Summary Summary NNP cord-010092-uftc8inx 9118 2 / / SYM cord-010092-uftc8inx 9118 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 9118 4 : : : cord-010092-uftc8inx 9119 1 The the DT cord-010092-uftc8inx 9119 2 performance performance NN cord-010092-uftc8inx 9119 3 of of IN cord-010092-uftc8inx 9119 4 the the DT cord-010092-uftc8inx 9119 5 IH-1000 ih-1000 NN cord-010092-uftc8inx 9119 6 system system NN cord-010092-uftc8inx 9119 7 using use VBG cord-010092-uftc8inx 9119 8 a a DT cord-010092-uftc8inx 9119 9 3-cell 3-cell CD cord-010092-uftc8inx 9119 10 screening screening NN cord-010092-uftc8inx 9119 11 panel panel NN cord-010092-uftc8inx 9119 12 including include VBG cord-010092-uftc8inx 9119 13 one one CD cord-010092-uftc8inx 9119 14 cell cell NN cord-010092-uftc8inx 9119 15 with with IN cord-010092-uftc8inx 9119 16 Mi(a+ Mi(a+ NNP cord-010092-uftc8inx 9119 17 ) ) -RRB- cord-010092-uftc8inx 9119 18 expression expression NN cord-010092-uftc8inx 9119 19 and and CC cord-010092-uftc8inx 9119 20 column column NN cord-010092-uftc8inx 9119 21 agglutination agglutination NN cord-010092-uftc8inx 9119 22 technology technology NN cord-010092-uftc8inx 9119 23 with with IN cord-010092-uftc8inx 9119 24 IAT IAT NNP cord-010092-uftc8inx 9119 25 phase phase NN cord-010092-uftc8inx 9119 26 was be VBD cord-010092-uftc8inx 9119 27 superior superior JJ cord-010092-uftc8inx 9119 28 in in IN cord-010092-uftc8inx 9119 29 comparison comparison NN cord-010092-uftc8inx 9119 30 with with IN cord-010092-uftc8inx 9119 31 that that DT cord-010092-uftc8inx 9119 32 of of IN cord-010092-uftc8inx 9119 33 PK7300 pk7300 NN cord-010092-uftc8inx 9119 34 in in IN cord-010092-uftc8inx 9119 35 the the DT cord-010092-uftc8inx 9119 36 context context NN cord-010092-uftc8inx 9119 37 of of IN cord-010092-uftc8inx 9119 38 higher high JJR cord-010092-uftc8inx 9119 39 sensitivity sensitivity NN cord-010092-uftc8inx 9119 40 in in IN cord-010092-uftc8inx 9119 41 detecting detect VBG cord-010092-uftc8inx 9119 42 more more RBR cord-010092-uftc8inx 9119 43 true true JJ cord-010092-uftc8inx 9119 44 positive positive JJ cord-010092-uftc8inx 9119 45 results result NNS cord-010092-uftc8inx 9119 46 and and CC cord-010092-uftc8inx 9119 47 higher high JJR cord-010092-uftc8inx 9119 48 specificity specificity NN cord-010092-uftc8inx 9119 49 in in IN cord-010092-uftc8inx 9119 50 detecting detect VBG cord-010092-uftc8inx 9119 51 more more RBR cord-010092-uftc8inx 9119 52 true true JJ cord-010092-uftc8inx 9119 53 negative negative JJ cord-010092-uftc8inx 9119 54 and and CC cord-010092-uftc8inx 9119 55 less less RBR cord-010092-uftc8inx 9119 56 false false JJ cord-010092-uftc8inx 9119 57 positive positive JJ cord-010092-uftc8inx 9119 58 results result NNS cord-010092-uftc8inx 9119 59 . . . cord-010092-uftc8inx 9120 1 This this DT cord-010092-uftc8inx 9120 2 has have VBZ cord-010092-uftc8inx 9120 3 translated translate VBN cord-010092-uftc8inx 9120 4 into into IN cord-010092-uftc8inx 9120 5 the the DT cord-010092-uftc8inx 9120 6 advantages advantage NNS cord-010092-uftc8inx 9120 7 of of IN cord-010092-uftc8inx 9120 8 reduction reduction NN cord-010092-uftc8inx 9120 9 in in IN cord-010092-uftc8inx 9120 10 workload workload NN cord-010092-uftc8inx 9120 11 of of IN cord-010092-uftc8inx 9120 12 Reference Reference NNP cord-010092-uftc8inx 9120 13 Laboratory Laboratory NNP cord-010092-uftc8inx 9120 14 in in IN cord-010092-uftc8inx 9120 15 performing perform VBG cord-010092-uftc8inx 9120 16 less less JJR cord-010092-uftc8inx 9120 17 antibody antibody NN cord-010092-uftc8inx 9120 18 identifications identification NNS cord-010092-uftc8inx 9120 19 in in IN cord-010092-uftc8inx 9120 20 those those DT cord-010092-uftc8inx 9120 21 false false JJ cord-010092-uftc8inx 9120 22 positive positive JJ cord-010092-uftc8inx 9120 23 samples sample NNS cord-010092-uftc8inx 9120 24 as as RB cord-010092-uftc8inx 9120 25 well well RB cord-010092-uftc8inx 9120 26 as as IN cord-010092-uftc8inx 9120 27 enhanced enhance VBN cord-010092-uftc8inx 9120 28 transfusion transfusion NN cord-010092-uftc8inx 9120 29 safety safety NN cord-010092-uftc8inx 9120 30 by by IN cord-010092-uftc8inx 9120 31 removing remove VBG cord-010092-uftc8inx 9120 32 more more RBR cord-010092-uftc8inx 9120 33 irregular irregular JJ cord-010092-uftc8inx 9120 34 red red JJ cord-010092-uftc8inx 9120 35 cell cell NN cord-010092-uftc8inx 9120 36 antibody antibody NN cord-010092-uftc8inx 9120 37 positive positive JJ cord-010092-uftc8inx 9120 38 plasma plasma NN cord-010092-uftc8inx 9120 39 - - HYPH cord-010092-uftc8inx 9120 40 containing contain VBG cord-010092-uftc8inx 9120 41 components component NNS cord-010092-uftc8inx 9120 42 from from IN cord-010092-uftc8inx 9120 43 the the DT cord-010092-uftc8inx 9120 44 issuable issuable JJ cord-010092-uftc8inx 9120 45 inventory inventory NN cord-010092-uftc8inx 9120 46 , , , cord-010092-uftc8inx 9120 47 which which WDT cord-010092-uftc8inx 9120 48 may may MD cord-010092-uftc8inx 9120 49 potentially potentially RB cord-010092-uftc8inx 9120 50 lead lead VB cord-010092-uftc8inx 9120 51 to to IN cord-010092-uftc8inx 9120 52 haemolytic haemolytic JJ cord-010092-uftc8inx 9120 53 transfusion transfusion NN cord-010092-uftc8inx 9120 54 reactions reaction NNS cord-010092-uftc8inx 9120 55 . . . cord-010092-uftc8inx 9121 1 The the DT cord-010092-uftc8inx 9121 2 prevalence prevalence NN cord-010092-uftc8inx 9121 3 of of IN cord-010092-uftc8inx 9121 4 irregular irregular JJ cord-010092-uftc8inx 9121 5 red red JJ cord-010092-uftc8inx 9121 6 cell cell NN cord-010092-uftc8inx 9121 7 antibodies antibody NNS cord-010092-uftc8inx 9121 8 of of IN cord-010092-uftc8inx 9121 9 0.55 0.55 CD cord-010092-uftc8inx 9121 10 % % NN cord-010092-uftc8inx 9121 11 in in IN cord-010092-uftc8inx 9121 12 healthy healthy JJ cord-010092-uftc8inx 9121 13 blood blood NN cord-010092-uftc8inx 9121 14 donors donor NNS cord-010092-uftc8inx 9121 15 in in IN cord-010092-uftc8inx 9121 16 Hong Hong NNP cord-010092-uftc8inx 9121 17 Kong Kong NNP cord-010092-uftc8inx 9121 18 reflects reflect VBZ cord-010092-uftc8inx 9121 19 more more RBR cord-010092-uftc8inx 9121 20 the the DT cord-010092-uftc8inx 9121 21 true true JJ cord-010092-uftc8inx 9121 22 statistical statistical JJ cord-010092-uftc8inx 9121 23 figure figure NN cord-010092-uftc8inx 9121 24 . . . cord-010092-uftc8inx 9122 1 Background background NN cord-010092-uftc8inx 9122 2 : : : cord-010092-uftc8inx 9123 1 Chronic chronic JJ cord-010092-uftc8inx 9123 2 Red Red NNP cord-010092-uftc8inx 9123 3 Blood blood NN cord-010092-uftc8inx 9123 4 Cell Cell NNP cord-010092-uftc8inx 9123 5 ( ( -LRB- cord-010092-uftc8inx 9123 6 RBC RBC NNP cord-010092-uftc8inx 9123 7 ) ) -RRB- cord-010092-uftc8inx 9123 8 transfusion transfusion NN cord-010092-uftc8inx 9123 9 is be VBZ cord-010092-uftc8inx 9123 10 the the DT cord-010092-uftc8inx 9123 11 upfront upfront JJ cord-010092-uftc8inx 9123 12 therapy therapy NN cord-010092-uftc8inx 9123 13 for for IN cord-010092-uftc8inx 9123 14 thalassaemia thalassaemia NN cord-010092-uftc8inx 9123 15 patients patient NNS cord-010092-uftc8inx 9123 16 , , , cord-010092-uftc8inx 9123 17 however however RB cord-010092-uftc8inx 9123 18 this this DT cord-010092-uftc8inx 9123 19 therapy therapy NN cord-010092-uftc8inx 9123 20 is be VBZ cord-010092-uftc8inx 9123 21 featured feature VBN cord-010092-uftc8inx 9123 22 by by IN cord-010092-uftc8inx 9123 23 several several JJ cord-010092-uftc8inx 9123 24 adverse adverse JJ cord-010092-uftc8inx 9123 25 events event NNS cord-010092-uftc8inx 9123 26 including include VBG cord-010092-uftc8inx 9123 27 RBC RBC NNP cord-010092-uftc8inx 9123 28 alloimmunization alloimmunization NN cord-010092-uftc8inx 9123 29 . . . cord-010092-uftc8inx 9124 1 Phenotype phenotype NN cord-010092-uftc8inx 9124 2 matched match VBN cord-010092-uftc8inx 9124 3 products product NNS cord-010092-uftc8inx 9124 4 transfusion transfusion NN cord-010092-uftc8inx 9124 5 policy policy NN cord-010092-uftc8inx 9124 6 can can MD cord-010092-uftc8inx 9124 7 prevent prevent VB cord-010092-uftc8inx 9124 8 alloantibody alloantibody NN cord-010092-uftc8inx 9124 9 formation formation NN cord-010092-uftc8inx 9124 10 , , , cord-010092-uftc8inx 9124 11 but but CC cord-010092-uftc8inx 9124 12 it -PRON- PRP cord-010092-uftc8inx 9124 13 makes make VBZ cord-010092-uftc8inx 9124 14 routine routine JJ cord-010092-uftc8inx 9124 15 transfusion transfusion NN cord-010092-uftc8inx 9124 16 more more RBR cord-010092-uftc8inx 9124 17 difficult difficult JJ cord-010092-uftc8inx 9124 18 for for IN cord-010092-uftc8inx 9124 19 both both CC cord-010092-uftc8inx 9124 20 the the DT cord-010092-uftc8inx 9124 21 donor donor NN cord-010092-uftc8inx 9124 22 center center NN cord-010092-uftc8inx 9124 23 and and CC cord-010092-uftc8inx 9124 24 the the DT cord-010092-uftc8inx 9124 25 transfusion transfusion NN cord-010092-uftc8inx 9124 26 service service NN cord-010092-uftc8inx 9124 27 . . . cord-010092-uftc8inx 9125 1 A a DT cord-010092-uftc8inx 9125 2 recent recent JJ cord-010092-uftc8inx 9125 3 systematic systematic JJ cord-010092-uftc8inx 9125 4 review review NN cord-010092-uftc8inx 9125 5 ( ( -LRB- cord-010092-uftc8inx 9125 6 Franchini Franchini NNP cord-010092-uftc8inx 9125 7 et et NNP cord-010092-uftc8inx 9125 8 al al NNP cord-010092-uftc8inx 9125 9 , , , cord-010092-uftc8inx 9125 10 Blood blood NN cord-010092-uftc8inx 9125 11 Transfus Transfus NNP cord-010092-uftc8inx 9125 12 2019 2019 CD cord-010092-uftc8inx 9125 13 ) ) -RRB- cord-010092-uftc8inx 9125 14 reported report VBD cord-010092-uftc8inx 9125 15 a a DT cord-010092-uftc8inx 9125 16 RBCalloimmunization rbcalloimmunization NN cord-010092-uftc8inx 9125 17 prevalence prevalence NN cord-010092-uftc8inx 9125 18 of of IN cord-010092-uftc8inx 9125 19 11.4 11.4 CD cord-010092-uftc8inx 9125 20 % % NN cord-010092-uftc8inx 9125 21 , , , cord-010092-uftc8inx 9125 22 with with IN cord-010092-uftc8inx 9125 23 a a DT cord-010092-uftc8inx 9125 24 higher high JJR cord-010092-uftc8inx 9125 25 incidence incidence NN cord-010092-uftc8inx 9125 26 against against IN cord-010092-uftc8inx 9125 27 Rh Rh NNP cord-010092-uftc8inx 9125 28 and and CC cord-010092-uftc8inx 9125 29 Kell Kell NNP cord-010092-uftc8inx 9125 30 systems system NNS cord-010092-uftc8inx 9125 31 in in IN cord-010092-uftc8inx 9125 32 thalassemia thalassemia NN cord-010092-uftc8inx 9125 33 intermedia intermedia NN cord-010092-uftc8inx 9125 34 patients patient NNS cord-010092-uftc8inx 9125 35 . . . cord-010092-uftc8inx 9126 1 Aims aim VBZ cord-010092-uftc8inx 9126 2 : : : cord-010092-uftc8inx 9127 1 The the DT cord-010092-uftc8inx 9127 2 aim aim NN cord-010092-uftc8inx 9127 3 of of IN cord-010092-uftc8inx 9127 4 our -PRON- PRP$ cord-010092-uftc8inx 9127 5 retrospective retrospective JJ cord-010092-uftc8inx 9127 6 study study NN cord-010092-uftc8inx 9127 7 is be VBZ cord-010092-uftc8inx 9127 8 to to TO cord-010092-uftc8inx 9127 9 evaluate evaluate VB cord-010092-uftc8inx 9127 10 the the DT cord-010092-uftc8inx 9127 11 RBC RBC NNP cord-010092-uftc8inx 9127 12 alloimmunization alloimmunization NN cord-010092-uftc8inx 9127 13 prevalence prevalence NN cord-010092-uftc8inx 9127 14 in in IN cord-010092-uftc8inx 9127 15 thalassemia thalassemia NN cord-010092-uftc8inx 9127 16 patients patient NNS cord-010092-uftc8inx 9127 17 transfused transfuse VBN cord-010092-uftc8inx 9127 18 in in IN cord-010092-uftc8inx 9127 19 a a DT cord-010092-uftc8inx 9127 20 single single JJ cord-010092-uftc8inx 9127 21 center center NN cord-010092-uftc8inx 9127 22 over over IN cord-010092-uftc8inx 9127 23 a a DT cord-010092-uftc8inx 9127 24 18 18 CD cord-010092-uftc8inx 9127 25 years year NNS cord-010092-uftc8inx 9127 26 period period NN cord-010092-uftc8inx 9127 27 with with IN cord-010092-uftc8inx 9127 28 limited limited JJ cord-010092-uftc8inx 9127 29 phenotype phenotype NN cord-010092-uftc8inx 9127 30 matched match VBD cord-010092-uftc8inx 9127 31 RBC RBC NNP cord-010092-uftc8inx 9127 32 ( ( -LRB- cord-010092-uftc8inx 9127 33 Rh Rh NNP cord-010092-uftc8inx 9127 34 and and CC cord-010092-uftc8inx 9127 35 Kell Kell NNP cord-010092-uftc8inx 9127 36 system system NN cord-010092-uftc8inx 9127 37 antigens antigen NNS cord-010092-uftc8inx 9127 38 ) ) -RRB- cord-010092-uftc8inx 9127 39 units unit NNS cord-010092-uftc8inx 9127 40 . . . cord-010092-uftc8inx 9128 1 Methods method NNS cord-010092-uftc8inx 9128 2 : : : cord-010092-uftc8inx 9129 1 From from IN cord-010092-uftc8inx 9129 2 1990 1990 CD cord-010092-uftc8inx 9129 3 to to IN cord-010092-uftc8inx 9129 4 2018 2018 CD cord-010092-uftc8inx 9129 5 thalassaemia thalassaemia NN cord-010092-uftc8inx 9129 6 patients patient NNS cord-010092-uftc8inx 9129 7 , , , cord-010092-uftc8inx 9129 8 with with IN cord-010092-uftc8inx 9129 9 a a DT cord-010092-uftc8inx 9129 10 minimum minimum NN cord-010092-uftc8inx 9129 11 follow follow NN cord-010092-uftc8inx 9129 12 up up IN cord-010092-uftc8inx 9129 13 of of IN cord-010092-uftc8inx 9129 14 1 1 CD cord-010092-uftc8inx 9129 15 year year NN cord-010092-uftc8inx 9129 16 and and CC cord-010092-uftc8inx 9129 17 transfused transfuse VBN cord-010092-uftc8inx 9129 18 with with IN cord-010092-uftc8inx 9129 19 more more JJR cord-010092-uftc8inx 9129 20 than than IN cord-010092-uftc8inx 9129 21 > > XX cord-010092-uftc8inx 9129 22 10 10 CD cord-010092-uftc8inx 9129 23 RBC RBC NNP cord-010092-uftc8inx 9129 24 units unit NNS cord-010092-uftc8inx 9129 25 , , , cord-010092-uftc8inx 9129 26 were be VBD cord-010092-uftc8inx 9129 27 included include VBN cord-010092-uftc8inx 9129 28 in in IN cord-010092-uftc8inx 9129 29 our -PRON- PRP$ cord-010092-uftc8inx 9129 30 study study NN cord-010092-uftc8inx 9129 31 . . . cord-010092-uftc8inx 9130 1 Patients patient NNS cord-010092-uftc8inx 9130 2 were be VBD cord-010092-uftc8inx 9130 3 studied study VBN cord-010092-uftc8inx 9130 4 for for IN cord-010092-uftc8inx 9130 5 : : : cord-010092-uftc8inx 9130 6 blood blood NN cord-010092-uftc8inx 9130 7 group group NN cord-010092-uftc8inx 9130 8 and and CC cord-010092-uftc8inx 9130 9 Rh Rh NNP cord-010092-uftc8inx 9130 10 / / SYM cord-010092-uftc8inx 9130 11 K K NNP cord-010092-uftc8inx 9130 12 phenotype phenotype NN cord-010092-uftc8inx 9130 13 determination determination NN cord-010092-uftc8inx 9130 14 , , , cord-010092-uftc8inx 9130 15 direct direct JJ cord-010092-uftc8inx 9130 16 antiglobulin antiglobulin NN cord-010092-uftc8inx 9130 17 test test NN cord-010092-uftc8inx 9130 18 ( ( -LRB- cord-010092-uftc8inx 9130 19 DAT DAT NNP cord-010092-uftc8inx 9130 20 ) ) -RRB- cord-010092-uftc8inx 9130 21 , , , cord-010092-uftc8inx 9130 22 irregular irregular JJ cord-010092-uftc8inx 9130 23 antibodies antibody NNS cord-010092-uftc8inx 9130 24 research research NN cord-010092-uftc8inx 9130 25 ( ( -LRB- cord-010092-uftc8inx 9130 26 AbIrr AbIrr NNP cord-010092-uftc8inx 9130 27 ) ) -RRB- cord-010092-uftc8inx 9130 28 . . . cord-010092-uftc8inx 9131 1 Cross cross NN cord-010092-uftc8inx 9131 2 - - NN cord-010092-uftc8inx 9131 3 match match NN cord-010092-uftc8inx 9131 4 and and CC cord-010092-uftc8inx 9131 5 detection detection NN cord-010092-uftc8inx 9131 6 of of IN cord-010092-uftc8inx 9131 7 alloantibodies alloantibody NNS cord-010092-uftc8inx 9131 8 were be VBD cord-010092-uftc8inx 9131 9 performed perform VBN cord-010092-uftc8inx 9131 10 using use VBG cord-010092-uftc8inx 9131 11 the the DT cord-010092-uftc8inx 9131 12 indirect indirect JJ cord-010092-uftc8inx 9131 13 antiglobulin antiglobulin NN cord-010092-uftc8inx 9131 14 test test NN cord-010092-uftc8inx 9131 15 by by IN cord-010092-uftc8inx 9131 16 the the DT cord-010092-uftc8inx 9131 17 column column NN cord-010092-uftc8inx 9131 18 agglutination agglutination NN cord-010092-uftc8inx 9131 19 method method NN cord-010092-uftc8inx 9131 20 . . . cord-010092-uftc8inx 9132 1 Six six CD cord-010092-uftc8inx 9132 2 - - HYPH cord-010092-uftc8inx 9132 3 monthly monthly JJ cord-010092-uftc8inx 9132 4 DAT dat NN cord-010092-uftc8inx 9132 5 and and CC cord-010092-uftc8inx 9132 6 antibody antibody NN cord-010092-uftc8inx 9132 7 screening screening NN cord-010092-uftc8inx 9132 8 were be VBD cord-010092-uftc8inx 9132 9 performed perform VBN cord-010092-uftc8inx 9132 10 using use VBG cord-010092-uftc8inx 9132 11 the the DT cord-010092-uftc8inx 9132 12 indirect indirect JJ cord-010092-uftc8inx 9132 13 antiglobulin antiglobulin NN cord-010092-uftc8inx 9132 14 test test NN cord-010092-uftc8inx 9132 15 and and CC cord-010092-uftc8inx 9132 16 enzymatic enzymatic JJ cord-010092-uftc8inx 9132 17 papain papain NN cord-010092-uftc8inx 9132 18 - - HYPH cord-010092-uftc8inx 9132 19 treated treat VBN cord-010092-uftc8inx 9132 20 RBC RBC NNP cord-010092-uftc8inx 9132 21 test test NN cord-010092-uftc8inx 9132 22 . . . cord-010092-uftc8inx 9133 1 Results result NNS cord-010092-uftc8inx 9133 2 : : : cord-010092-uftc8inx 9134 1 Overall overall JJ cord-010092-uftc8inx 9134 2 57 57 CD cord-010092-uftc8inx 9134 3 patients patient NNS cord-010092-uftc8inx 9134 4 ( ( -LRB- cord-010092-uftc8inx 9134 5 38 38 CD cord-010092-uftc8inx 9134 6 females female NNS cord-010092-uftc8inx 9134 7 , , , cord-010092-uftc8inx 9134 8 19 19 CD cord-010092-uftc8inx 9134 9 males male NNS cord-010092-uftc8inx 9134 10 ) ) -RRB- cord-010092-uftc8inx 9134 11 were be VBD cord-010092-uftc8inx 9134 12 included include VBN cord-010092-uftc8inx 9134 13 in in IN cord-010092-uftc8inx 9134 14 our -PRON- PRP$ cord-010092-uftc8inx 9134 15 retrospective retrospective JJ cord-010092-uftc8inx 9134 16 analysis analysis NN cord-010092-uftc8inx 9134 17 : : : cord-010092-uftc8inx 9134 18 54 54 CD cord-010092-uftc8inx 9134 19 patients patient NNS cord-010092-uftc8inx 9134 20 were be VBD cord-010092-uftc8inx 9134 21 affected affect VBN cord-010092-uftc8inx 9134 22 by by IN cord-010092-uftc8inx 9134 23 Thalassaemia Thalassaemia NNP cord-010092-uftc8inx 9134 24 Major Major NNP cord-010092-uftc8inx 9134 25 and and CC cord-010092-uftc8inx 9134 26 3 3 CD cord-010092-uftc8inx 9134 27 by by IN cord-010092-uftc8inx 9134 28 Thalassaemia Thalassaemia NNP cord-010092-uftc8inx 9134 29 Intermedia Intermedia NNP cord-010092-uftc8inx 9134 30 . . . cord-010092-uftc8inx 9135 1 RBC RBC NNP cord-010092-uftc8inx 9135 2 alloimmunization alloimmunization NN cord-010092-uftc8inx 9135 3 prevalence prevalence NN cord-010092-uftc8inx 9135 4 was be VBD cord-010092-uftc8inx 9135 5 12.3 12.3 CD cord-010092-uftc8inx 9135 6 % % NN cord-010092-uftc8inx 9135 7 ( ( -LRB- cord-010092-uftc8inx 9135 8 7 7 CD cord-010092-uftc8inx 9135 9 patients patient NNS cord-010092-uftc8inx 9135 10 ) ) -RRB- cord-010092-uftc8inx 9135 11 : : : cord-010092-uftc8inx 9135 12 3 3 CD cord-010092-uftc8inx 9135 13 patients patient NNS cord-010092-uftc8inx 9135 14 were be VBD cord-010092-uftc8inx 9135 15 found find VBN cord-010092-uftc8inx 9135 16 to to TO cord-010092-uftc8inx 9135 17 be be VB cord-010092-uftc8inx 9135 18 positive positive JJ cord-010092-uftc8inx 9135 19 for for IN cord-010092-uftc8inx 9135 20 RBC RBC NNP cord-010092-uftc8inx 9135 21 alloantibodies alloantibody NNS cord-010092-uftc8inx 9135 22 , , , cord-010092-uftc8inx 9135 23 four four CD cord-010092-uftc8inx 9135 24 with with IN cord-010092-uftc8inx 9135 25 alloantibodies alloantibody NNS cord-010092-uftc8inx 9135 26 and and CC cord-010092-uftc8inx 9135 27 autoantibodies autoantibody NNS cord-010092-uftc8inx 9135 28 . . . cord-010092-uftc8inx 9136 1 Eleven eleven CD cord-010092-uftc8inx 9136 2 alloantibodies alloantibody NNS cord-010092-uftc8inx 9136 3 were be VBD cord-010092-uftc8inx 9136 4 detected detect VBN cord-010092-uftc8inx 9136 5 ( ( -LRB- cord-010092-uftc8inx 9136 6 1 1 CD cord-010092-uftc8inx 9136 7 anti anti JJ cord-010092-uftc8inx 9136 8 - - NNP cord-010092-uftc8inx 9136 9 H H NNP cord-010092-uftc8inx 9136 10 , , , cord-010092-uftc8inx 9136 11 1 1 CD cord-010092-uftc8inx 9136 12 anti anti NNP cord-010092-uftc8inx 9136 13 - - NNP cord-010092-uftc8inx 9136 14 Cw Cw NNP cord-010092-uftc8inx 9136 15 , , , cord-010092-uftc8inx 9136 16 4 4 CD cord-010092-uftc8inx 9136 17 anti anti JJ cord-010092-uftc8inx 9136 18 - - JJ cord-010092-uftc8inx 9136 19 E e JJ cord-010092-uftc8inx 9136 20 , , , cord-010092-uftc8inx 9136 21 1 1 CD cord-010092-uftc8inx 9136 22 Kpa Kpa NNPS cord-010092-uftc8inx 9136 23 , , , cord-010092-uftc8inx 9136 24 1 1 CD cord-010092-uftc8inx 9136 25 anti anti NNP cord-010092-uftc8inx 9136 26 - - NNP cord-010092-uftc8inx 9136 27 Jka Jka NNP cord-010092-uftc8inx 9136 28 , , , cord-010092-uftc8inx 9136 29 1 1 CD cord-010092-uftc8inx 9136 30 anti anti NNP cord-010092-uftc8inx 9136 31 - - NNP cord-010092-uftc8inx 9136 32 Jkb Jkb NNP cord-010092-uftc8inx 9136 33 , , , cord-010092-uftc8inx 9136 34 1 1 CD cord-010092-uftc8inx 9136 35 anti anti NNP cord-010092-uftc8inx 9136 36 - - NNP cord-010092-uftc8inx 9136 37 M M NNP cord-010092-uftc8inx 9136 38 and and CC cord-010092-uftc8inx 9136 39 1 1 CD cord-010092-uftc8inx 9136 40 anti anti JJ cord-010092-uftc8inx 9136 41 - - JJ cord-010092-uftc8inx 9136 42 Lua lua JJ cord-010092-uftc8inx 9136 43 ) ) -RRB- cord-010092-uftc8inx 9136 44 . . . cord-010092-uftc8inx 9137 1 In in IN cord-010092-uftc8inx 9137 2 2 2 CD cord-010092-uftc8inx 9137 3 out out IN cord-010092-uftc8inx 9137 4 of of IN cord-010092-uftc8inx 9137 5 3 3 CD cord-010092-uftc8inx 9137 6 alloimmunized alloimmunize VBN cord-010092-uftc8inx 9137 7 patients patient NNS cord-010092-uftc8inx 9137 8 we -PRON- PRP cord-010092-uftc8inx 9137 9 found find VBD cord-010092-uftc8inx 9137 10 an an DT cord-010092-uftc8inx 9137 11 anti anti JJ cord-010092-uftc8inx 9137 12 - - JJ cord-010092-uftc8inx 9137 13 E e JJ cord-010092-uftc8inx 9137 14 antibody antibody NN cord-010092-uftc8inx 9137 15 reactive reactive JJ cord-010092-uftc8inx 9137 16 in in IN cord-010092-uftc8inx 9137 17 enzymatic enzymatic JJ cord-010092-uftc8inx 9137 18 papain papain NN cord-010092-uftc8inx 9137 19 - - HYPH cord-010092-uftc8inx 9137 20 treated treat VBN cord-010092-uftc8inx 9137 21 RBC RBC NNP cord-010092-uftc8inx 9137 22 test test NN cord-010092-uftc8inx 9137 23 only only RB cord-010092-uftc8inx 9137 24 , , , cord-010092-uftc8inx 9137 25 in in IN cord-010092-uftc8inx 9137 26 the the DT cord-010092-uftc8inx 9137 27 third third JJ cord-010092-uftc8inx 9137 28 alloimmunized alloimmunized JJ cord-010092-uftc8inx 9137 29 patient patient NN cord-010092-uftc8inx 9137 30 anti anti NNP cord-010092-uftc8inx 9137 31 - - NNP cord-010092-uftc8inx 9137 32 Kpa kpa JJ cord-010092-uftc8inx 9137 33 and and CC cord-010092-uftc8inx 9137 34 anti anti JJ cord-010092-uftc8inx 9137 35 - - JJ cord-010092-uftc8inx 9137 36 Lua lua JJ cord-010092-uftc8inx 9137 37 antibodies antibody NNS cord-010092-uftc8inx 9137 38 were be VBD cord-010092-uftc8inx 9137 39 detected detect VBN cord-010092-uftc8inx 9137 40 , , , cord-010092-uftc8inx 9137 41 while while IN cord-010092-uftc8inx 9137 42 in in IN cord-010092-uftc8inx 9137 43 the the DT cord-010092-uftc8inx 9137 44 remaining remain VBG cord-010092-uftc8inx 9137 45 4 4 CD cord-010092-uftc8inx 9137 46 patients patient NNS cord-010092-uftc8inx 9137 47 , , , cord-010092-uftc8inx 9137 48 in in IN cord-010092-uftc8inx 9137 49 which which WDT cord-010092-uftc8inx 9137 50 auto auto NN cord-010092-uftc8inx 9137 51 and and CC cord-010092-uftc8inx 9137 52 alloantibodies alloantibody NNS cord-010092-uftc8inx 9137 53 were be VBD cord-010092-uftc8inx 9137 54 detected detect VBN cord-010092-uftc8inx 9137 55 , , , cord-010092-uftc8inx 9137 56 a a DT cord-010092-uftc8inx 9137 57 severe severe JJ cord-010092-uftc8inx 9137 58 autoimmune autoimmune JJ cord-010092-uftc8inx 9137 59 hemolytic hemolytic JJ cord-010092-uftc8inx 9137 60 anaemia anaemia NN cord-010092-uftc8inx 9137 61 ( ( -LRB- cord-010092-uftc8inx 9137 62 AEA AEA NNP cord-010092-uftc8inx 9137 63 ) ) -RRB- cord-010092-uftc8inx 9137 64 requiring require VBG cord-010092-uftc8inx 9137 65 therapy therapy NN cord-010092-uftc8inx 9137 66 was be VBD cord-010092-uftc8inx 9137 67 diagnosed diagnose VBN cord-010092-uftc8inx 9137 68 . . . cord-010092-uftc8inx 9138 1 In in IN cord-010092-uftc8inx 9138 2 these these DT cord-010092-uftc8inx 9138 3 cases case NNS cord-010092-uftc8inx 9138 4 the the DT cord-010092-uftc8inx 9138 5 appearance appearance NN cord-010092-uftc8inx 9138 6 of of IN cord-010092-uftc8inx 9138 7 alloantibodies alloantibody NNS cord-010092-uftc8inx 9138 8 is be VBZ cord-010092-uftc8inx 9138 9 concomitant concomitant JJ cord-010092-uftc8inx 9138 10 with with IN cord-010092-uftc8inx 9138 11 the the DT cord-010092-uftc8inx 9138 12 presence presence NN cord-010092-uftc8inx 9138 13 of of IN cord-010092-uftc8inx 9138 14 autoantibodies autoantibody NNS cord-010092-uftc8inx 9138 15 . . . cord-010092-uftc8inx 9139 1 Among among IN cord-010092-uftc8inx 9139 2 the the DT cord-010092-uftc8inx 9139 3 7 7 CD cord-010092-uftc8inx 9139 4 patients patient NNS cord-010092-uftc8inx 9139 5 positive positive JJ cord-010092-uftc8inx 9139 6 for for IN cord-010092-uftc8inx 9139 7 alloantibodies alloantibody NNS cord-010092-uftc8inx 9139 8 , , , cord-010092-uftc8inx 9139 9 6 6 CD cord-010092-uftc8inx 9139 10 were be VBD cord-010092-uftc8inx 9139 11 affected affect VBN cord-010092-uftc8inx 9139 12 by by IN cord-010092-uftc8inx 9139 13 major major JJ cord-010092-uftc8inx 9139 14 thalassemia thalassemia NN cord-010092-uftc8inx 9139 15 and and CC cord-010092-uftc8inx 9139 16 one one CD cord-010092-uftc8inx 9139 17 by by IN cord-010092-uftc8inx 9139 18 intermedia intermedia NN cord-010092-uftc8inx 9139 19 thalassaemia thalassaemia NN cord-010092-uftc8inx 9139 20 Summary Summary NNP cord-010092-uftc8inx 9139 21 / / SYM cord-010092-uftc8inx 9139 22 Conclusions Conclusions NNPS cord-010092-uftc8inx 9139 23 : : : cord-010092-uftc8inx 9140 1 In in IN cord-010092-uftc8inx 9140 2 our -PRON- PRP$ cord-010092-uftc8inx 9140 3 experience experience NN cord-010092-uftc8inx 9140 4 a a DT cord-010092-uftc8inx 9140 5 limited limited JJ cord-010092-uftc8inx 9140 6 phenotype phenotype NN cord-010092-uftc8inx 9140 7 matched match VBD cord-010092-uftc8inx 9140 8 RBC RBC NNP cord-010092-uftc8inx 9140 9 transfusion transfusion NN cord-010092-uftc8inx 9140 10 policy policy NN cord-010092-uftc8inx 9140 11 showed show VBD cord-010092-uftc8inx 9140 12 a a DT cord-010092-uftc8inx 9140 13 RBC RBC NNP cord-010092-uftc8inx 9140 14 alloimmunization alloimmunization NN cord-010092-uftc8inx 9140 15 prevalence prevalence NN cord-010092-uftc8inx 9140 16 similar similar JJ cord-010092-uftc8inx 9140 17 to to IN cord-010092-uftc8inx 9140 18 literature literature NN cord-010092-uftc8inx 9140 19 data datum NNS cord-010092-uftc8inx 9140 20 : : : cord-010092-uftc8inx 9140 21 12.3 12.3 CD cord-010092-uftc8inx 9140 22 % % NN cord-010092-uftc8inx 9140 23 vs vs IN cord-010092-uftc8inx 9140 24 11.4 11.4 CD cord-010092-uftc8inx 9140 25 % % NN cord-010092-uftc8inx 9140 26 ; ; : cord-010092-uftc8inx 9140 27 we -PRON- PRP cord-010092-uftc8inx 9140 28 did do VBD cord-010092-uftc8inx 9140 29 n't not RB cord-010092-uftc8inx 9140 30 find find VB cord-010092-uftc8inx 9140 31 higher high JJR cord-010092-uftc8inx 9140 32 alloimmunization alloimmunization NN cord-010092-uftc8inx 9140 33 prevalence prevalence NN cord-010092-uftc8inx 9140 34 in in IN cord-010092-uftc8inx 9140 35 thalassemia thalassemia NN cord-010092-uftc8inx 9140 36 intermedia intermedia NN cord-010092-uftc8inx 9140 37 patients patient NNS cord-010092-uftc8inx 9140 38 may may MD cord-010092-uftc8inx 9140 39 be be VB cord-010092-uftc8inx 9140 40 due due JJ cord-010092-uftc8inx 9140 41 to to IN cord-010092-uftc8inx 9140 42 the the DT cord-010092-uftc8inx 9140 43 low low JJ cord-010092-uftc8inx 9140 44 patients patient NNS cord-010092-uftc8inx 9140 45 number number NN cord-010092-uftc8inx 9140 46 . . . cord-010092-uftc8inx 9141 1 We -PRON- PRP cord-010092-uftc8inx 9141 2 believe believe VBP cord-010092-uftc8inx 9141 3 that that IN cord-010092-uftc8inx 9141 4 introduction introduction NN cord-010092-uftc8inx 9141 5 , , , cord-010092-uftc8inx 9141 6 in in IN cord-010092-uftc8inx 9141 7 our -PRON- PRP$ cord-010092-uftc8inx 9141 8 department department NN cord-010092-uftc8inx 9141 9 , , , cord-010092-uftc8inx 9141 10 of of IN cord-010092-uftc8inx 9141 11 an an DT cord-010092-uftc8inx 9141 12 extended extend VBN cord-010092-uftc8inx 9141 13 - - HYPH cord-010092-uftc8inx 9141 14 phenotype phenotype NN cord-010092-uftc8inx 9141 15 matched match VBN cord-010092-uftc8inx 9141 16 transfusion transfusion NN cord-010092-uftc8inx 9141 17 , , , cord-010092-uftc8inx 9141 18 including include VBG cord-010092-uftc8inx 9141 19 antigens antigen NNS cord-010092-uftc8inx 9141 20 of of IN cord-010092-uftc8inx 9141 21 the the DT cord-010092-uftc8inx 9141 22 main main JJ cord-010092-uftc8inx 9141 23 group group NN cord-010092-uftc8inx 9141 24 systems system NNS cord-010092-uftc8inx 9141 25 ( ( -LRB- cord-010092-uftc8inx 9141 26 Fy Fy NNP cord-010092-uftc8inx 9141 27 , , , cord-010092-uftc8inx 9141 28 Jk Jk NNP cord-010092-uftc8inx 9141 29 , , , cord-010092-uftc8inx 9141 30 MNS MNS NNP cord-010092-uftc8inx 9141 31 ) ) -RRB- cord-010092-uftc8inx 9141 32 and and CC cord-010092-uftc8inx 9141 33 the the DT cord-010092-uftc8inx 9141 34 main main JJ cord-010092-uftc8inx 9141 35 rare rare JJ cord-010092-uftc8inx 9141 36 antigens antigen NNS cord-010092-uftc8inx 9141 37 ( ( -LRB- cord-010092-uftc8inx 9141 38 Cw Cw NNP cord-010092-uftc8inx 9141 39 , , , cord-010092-uftc8inx 9141 40 Kp Kp NNP cord-010092-uftc8inx 9141 41 , , , cord-010092-uftc8inx 9141 42 Lu Lu NNP cord-010092-uftc8inx 9141 43 ) ) -RRB- cord-010092-uftc8inx 9141 44 , , , cord-010092-uftc8inx 9141 45 could could MD cord-010092-uftc8inx 9141 46 reduce reduce VB cord-010092-uftc8inx 9141 47 the the DT cord-010092-uftc8inx 9141 48 risk risk NN cord-010092-uftc8inx 9141 49 of of IN cord-010092-uftc8inx 9141 50 red red JJ cord-010092-uftc8inx 9141 51 blood blood NN cord-010092-uftc8inx 9141 52 cell cell NN cord-010092-uftc8inx 9141 53 alloimmunization alloimmunization NN cord-010092-uftc8inx 9141 54 in in IN cord-010092-uftc8inx 9141 55 thalassemia thalassemia NN cord-010092-uftc8inx 9141 56 patients patient NNS cord-010092-uftc8inx 9141 57 . . . cord-010092-uftc8inx 9142 1 Abstract Abstract NNP cord-010092-uftc8inx 9142 2 withdrawn withdraw VBN cord-010092-uftc8inx 9142 3 . . . cord-010092-uftc8inx 9143 1 Background background NN cord-010092-uftc8inx 9143 2 : : : cord-010092-uftc8inx 9144 1 Undoubtedly undoubtedly RB cord-010092-uftc8inx 9144 2 , , , cord-010092-uftc8inx 9144 3 preventing prevent VBG cord-010092-uftc8inx 9144 4 alloimmunization alloimmunization NN cord-010092-uftc8inx 9144 5 has have VBZ cord-010092-uftc8inx 9144 6 an an DT cord-010092-uftc8inx 9144 7 advantage advantage NN cord-010092-uftc8inx 9144 8 over over IN cord-010092-uftc8inx 9144 9 overcoming overcome VBG cord-010092-uftc8inx 9144 10 its -PRON- PRP$ cord-010092-uftc8inx 9144 11 consequences consequence NNS cord-010092-uftc8inx 9144 12 . . . cord-010092-uftc8inx 9145 1 However however RB cord-010092-uftc8inx 9145 2 , , , cord-010092-uftc8inx 9145 3 the the DT cord-010092-uftc8inx 9145 4 high high JJ cord-010092-uftc8inx 9145 5 cost cost NN cord-010092-uftc8inx 9145 6 of of IN cord-010092-uftc8inx 9145 7 technical technical JJ cord-010092-uftc8inx 9145 8 and and CC cord-010092-uftc8inx 9145 9 organizational organizational JJ cord-010092-uftc8inx 9145 10 aspects aspect NNS cord-010092-uftc8inx 9145 11 of of IN cord-010092-uftc8inx 9145 12 preventive preventive JJ cord-010092-uftc8inx 9145 13 measures measure NNS cord-010092-uftc8inx 9145 14 requires require VBZ cord-010092-uftc8inx 9145 15 their -PRON- PRP$ cord-010092-uftc8inx 9145 16 scientific scientific JJ cord-010092-uftc8inx 9145 17 substantiation substantiation NN cord-010092-uftc8inx 9145 18 confirmed confirm VBN cord-010092-uftc8inx 9145 19 by by IN cord-010092-uftc8inx 9145 20 clinical clinical JJ cord-010092-uftc8inx 9145 21 and and CC cord-010092-uftc8inx 9145 22 laboratory laboratory NN cord-010092-uftc8inx 9145 23 data datum NNS cord-010092-uftc8inx 9145 24 . . . cord-010092-uftc8inx 9146 1 Selection selection NN cord-010092-uftc8inx 9146 2 of of IN cord-010092-uftc8inx 9146 3 donors donor NNS cord-010092-uftc8inx 9146 4 of of IN cord-010092-uftc8inx 9146 5 the the DT cord-010092-uftc8inx 9146 6 Rhesus Rhesus NNP cord-010092-uftc8inx 9146 7 ( ( -LRB- cord-010092-uftc8inx 9146 8 D D NNP cord-010092-uftc8inx 9146 9 , , , cord-010092-uftc8inx 9146 10 c c NN cord-010092-uftc8inx 9146 11 ) ) -RRB- cord-010092-uftc8inx 9146 12 and and CC cord-010092-uftc8inx 9146 13 Kell Kell NNP cord-010092-uftc8inx 9147 1 ( ( -LRB- cord-010092-uftc8inx 9147 2 K K NNP cord-010092-uftc8inx 9147 3 ) ) -RRB- cord-010092-uftc8inx 9147 4 antigens antigen NNS cord-010092-uftc8inx 9147 5 for for IN cord-010092-uftc8inx 9147 6 the the DT cord-010092-uftc8inx 9147 7 red red JJ cord-010092-uftc8inx 9147 8 blood blood NN cord-010092-uftc8inx 9147 9 cell cell NN cord-010092-uftc8inx 9147 10 transfusions transfusion NNS cord-010092-uftc8inx 9147 11 to to IN cord-010092-uftc8inx 9147 12 hematological hematological JJ cord-010092-uftc8inx 9147 13 patients patient NNS cord-010092-uftc8inx 9147 14 has have VBZ cord-010092-uftc8inx 9147 15 been be VBN cord-010092-uftc8inx 9147 16 regulated regulate VBN cord-010092-uftc8inx 9147 17 in in IN cord-010092-uftc8inx 9147 18 the the DT cord-010092-uftc8inx 9147 19 Russian Russian NNP cord-010092-uftc8inx 9147 20 Federation Federation NNP cord-010092-uftc8inx 9147 21 since since IN cord-010092-uftc8inx 9147 22 1998 1998 CD cord-010092-uftc8inx 9147 23 . . . cord-010092-uftc8inx 9148 1 Recipients recipient NNS cord-010092-uftc8inx 9148 2 with with IN cord-010092-uftc8inx 9148 3 the the DT cord-010092-uftc8inx 9148 4 phenotype phenotype NN cord-010092-uftc8inx 9148 5 C+c c+c NN cord-010092-uftc8inx 9148 6 - - HYPH cord-010092-uftc8inx 9148 7 transfuse transfuse JJ cord-010092-uftc8inx 9148 8 red red JJ cord-010092-uftc8inx 9148 9 blood blood NN cord-010092-uftc8inx 9148 10 cell cell NN cord-010092-uftc8inx 9148 11 only only RB cord-010092-uftc8inx 9148 12 with with IN cord-010092-uftc8inx 9148 13 the the DT cord-010092-uftc8inx 9148 14 same same JJ cord-010092-uftc8inx 9148 15 antigenic antigenic JJ cord-010092-uftc8inx 9148 16 combination combination NN cord-010092-uftc8inx 9148 17 . . . cord-010092-uftc8inx 9149 1 For for IN cord-010092-uftc8inx 9149 2 transfusions transfusion NNS cord-010092-uftc8inx 9149 3 red red JJ cord-010092-uftc8inx 9149 4 blood blood NN cord-010092-uftc8inx 9149 5 cell cell NN cord-010092-uftc8inx 9149 6 obtained obtain VBN cord-010092-uftc8inx 9149 7 from from IN cord-010092-uftc8inx 9149 8 K k NN cord-010092-uftc8inx 9149 9 - - HYPH cord-010092-uftc8inx 9149 10 negative negative JJ cord-010092-uftc8inx 9149 11 donors donor NNS cord-010092-uftc8inx 9149 12 are be VBP cord-010092-uftc8inx 9149 13 used use VBN cord-010092-uftc8inx 9149 14 . . . cord-010092-uftc8inx 9150 1 The the DT cord-010092-uftc8inx 9150 2 compatibility compatibility NN cord-010092-uftc8inx 9150 3 of of IN cord-010092-uftc8inx 9150 4 the the DT cord-010092-uftc8inx 9150 5 donor donor NN cord-010092-uftc8inx 9150 6 and and CC cord-010092-uftc8inx 9150 7 recipient recipient NN cord-010092-uftc8inx 9150 8 with with IN cord-010092-uftc8inx 9150 9 the the DT cord-010092-uftc8inx 9150 10 antigens antigen NNS cord-010092-uftc8inx 9150 11 C c NN cord-010092-uftc8inx 9150 12 , , , cord-010092-uftc8inx 9150 13 E E NNP cord-010092-uftc8inx 9150 14 , , , cord-010092-uftc8inx 9150 15 e e NNP cord-010092-uftc8inx 9150 16 , , , cord-010092-uftc8inx 9150 17 C C NNP cord-010092-uftc8inx 9150 18 W W NNP cord-010092-uftc8inx 9150 19 ( ( -LRB- cord-010092-uftc8inx 9150 20 Rhesus Rhesus NNP cord-010092-uftc8inx 9150 21 system system NN cord-010092-uftc8inx 9150 22 ) ) -RRB- cord-010092-uftc8inx 9150 23 and and CC cord-010092-uftc8inx 9150 24 k k NNP cord-010092-uftc8inx 9150 25 ( ( -LRB- cord-010092-uftc8inx 9150 26 Kell Kell NNP cord-010092-uftc8inx 9150 27 system system NN cord-010092-uftc8inx 9150 28 ) ) -RRB- cord-010092-uftc8inx 9150 29 is be VBZ cord-010092-uftc8inx 9150 30 additionally additionally RB cord-010092-uftc8inx 9150 31 taken take VBN cord-010092-uftc8inx 9150 32 into into IN cord-010092-uftc8inx 9150 33 account account NN cord-010092-uftc8inx 9150 34 from from IN cord-010092-uftc8inx 9150 35 April April NNP cord-010092-uftc8inx 9150 36 2013 2013 CD cord-010092-uftc8inx 9150 37 . . . cord-010092-uftc8inx 9151 1 That that DT cord-010092-uftc8inx 9151 2 is is RB cord-010092-uftc8inx 9151 3 , , , cord-010092-uftc8inx 9151 4 transfuse transfuse IN cord-010092-uftc8inx 9151 5 red red JJ cord-010092-uftc8inx 9151 6 blood blood NN cord-010092-uftc8inx 9151 7 cell cell NN cord-010092-uftc8inx 9151 8 that that WDT cord-010092-uftc8inx 9151 9 do do VBP cord-010092-uftc8inx 9151 10 not not RB cord-010092-uftc8inx 9151 11 contain contain VB cord-010092-uftc8inx 9151 12 antigens antigen NNS cord-010092-uftc8inx 9151 13 in in IN cord-010092-uftc8inx 9151 14 the the DT cord-010092-uftc8inx 9151 15 phenotype phenotype NN cord-010092-uftc8inx 9151 16 that that WDT cord-010092-uftc8inx 9151 17 are be VBP cord-010092-uftc8inx 9151 18 not not RB cord-010092-uftc8inx 9151 19 in in IN cord-010092-uftc8inx 9151 20 the the DT cord-010092-uftc8inx 9151 21 recipient recipient NN cord-010092-uftc8inx 9151 22 's 's POS cord-010092-uftc8inx 9151 23 phenotype phenotype NN cord-010092-uftc8inx 9151 24 . . . cord-010092-uftc8inx 9152 1 Aims aim VBZ cord-010092-uftc8inx 9152 2 : : : cord-010092-uftc8inx 9152 3 To to TO cord-010092-uftc8inx 9152 4 evaluate evaluate VB cord-010092-uftc8inx 9152 5 the the DT cord-010092-uftc8inx 9152 6 efficiency efficiency NN cord-010092-uftc8inx 9152 7 of of IN cord-010092-uftc8inx 9152 8 red red JJ cord-010092-uftc8inx 9152 9 blood blood NN cord-010092-uftc8inx 9152 10 cell cell NN cord-010092-uftc8inx 9152 11 donor donor NN cord-010092-uftc8inx 9152 12 selection selection NN cord-010092-uftc8inx 9152 13 using use VBG cord-010092-uftc8inx 9152 14 antigens antigen NNS cord-010092-uftc8inx 9152 15 of of IN cord-010092-uftc8inx 9152 16 Rhesus Rhesus NNP cord-010092-uftc8inx 9152 17 ( ( -LRB- cord-010092-uftc8inx 9152 18 C C NNP cord-010092-uftc8inx 9152 19 , , , cord-010092-uftc8inx 9152 20 c c NNP cord-010092-uftc8inx 9152 21 , , , cord-010092-uftc8inx 9152 22 E E NNP cord-010092-uftc8inx 9152 23 , , , cord-010092-uftc8inx 9152 24 e e NNP cord-010092-uftc8inx 9152 25 , , , cord-010092-uftc8inx 9152 26 C C NNP cord-010092-uftc8inx 9152 27 W W NNP cord-010092-uftc8inx 9152 28 ) ) -RRB- cord-010092-uftc8inx 9153 1 and and CC cord-010092-uftc8inx 9153 2 Kell Kell NNP cord-010092-uftc8inx 9153 3 ( ( -LRB- cord-010092-uftc8inx 9153 4 K K NNP cord-010092-uftc8inx 9153 5 , , , cord-010092-uftc8inx 9153 6 k k NNP cord-010092-uftc8inx 9153 7 ) ) -RRB- cord-010092-uftc8inx 9153 8 systems system NNS cord-010092-uftc8inx 9153 9 for for IN cord-010092-uftc8inx 9153 10 the the DT cord-010092-uftc8inx 9153 11 prevention prevention NN cord-010092-uftc8inx 9153 12 of of IN cord-010092-uftc8inx 9153 13 the the DT cord-010092-uftc8inx 9153 14 recipient recipient NN cord-010092-uftc8inx 9153 15 alloimmunization alloimmunization NN cord-010092-uftc8inx 9153 16 . . . cord-010092-uftc8inx 9154 1 Methods method NNS cord-010092-uftc8inx 9154 2 : : : cord-010092-uftc8inx 9155 1 Immunohaematological Immunohaematological NNP cord-010092-uftc8inx 9155 2 studies study NNS cord-010092-uftc8inx 9155 3 using use VBG cord-010092-uftc8inx 9155 4 equipment equipment NN cord-010092-uftc8inx 9155 5 and and CC cord-010092-uftc8inx 9155 6 reagents reagent NNS cord-010092-uftc8inx 9155 7 of of IN cord-010092-uftc8inx 9155 8 BioRad BioRad NNP cord-010092-uftc8inx 9155 9 ( ( -LRB- cord-010092-uftc8inx 9155 10 USA USA NNP cord-010092-uftc8inx 9155 11 ) ) -RRB- cord-010092-uftc8inx 9155 12 were be VBD cord-010092-uftc8inx 9155 13 performed perform VBN cord-010092-uftc8inx 9155 14 in in IN cord-010092-uftc8inx 9155 15 3642 3642 CD cord-010092-uftc8inx 9155 16 patients patient NNS cord-010092-uftc8inx 9155 17 of of IN cord-010092-uftc8inx 9155 18 the the DT cord-010092-uftc8inx 9155 19 hematology hematology NN cord-010092-uftc8inx 9155 20 clinic clinic NN cord-010092-uftc8inx 9155 21 . . . cord-010092-uftc8inx 9156 1 Non Non NNP cord-010092-uftc8inx 9156 2 - - JJ cord-010092-uftc8inx 9156 3 Hodgkin Hodgkin NNP cord-010092-uftc8inx 9156 4 lymphoma lymphoma NN cord-010092-uftc8inx 9156 5 was be VBD cord-010092-uftc8inx 9156 6 diagnosed diagnose VBN cord-010092-uftc8inx 9156 7 in in IN cord-010092-uftc8inx 9156 8 759 759 CD cord-010092-uftc8inx 9156 9 patients patient NNS cord-010092-uftc8inx 9156 10 , , , cord-010092-uftc8inx 9156 11 acute acute JJ cord-010092-uftc8inx 9156 12 leukemia leukemia NN cord-010092-uftc8inx 9156 13 in in IN cord-010092-uftc8inx 9156 14 600 600 CD cord-010092-uftc8inx 9156 15 , , , cord-010092-uftc8inx 9156 16 multiple multiple JJ cord-010092-uftc8inx 9156 17 myeloma myeloma NN cord-010092-uftc8inx 9156 18 in in IN cord-010092-uftc8inx 9156 19 390 390 CD cord-010092-uftc8inx 9156 20 , , , cord-010092-uftc8inx 9156 21 chronic chronic JJ cord-010092-uftc8inx 9156 22 lymphatic lymphatic NN cord-010092-uftc8inx 9156 23 leukemia leukemia NN cord-010092-uftc8inx 9156 24 in in IN cord-010092-uftc8inx 9156 25 319 319 CD cord-010092-uftc8inx 9156 26 , , , cord-010092-uftc8inx 9156 27 chronic chronic JJ cord-010092-uftc8inx 9156 28 myeloid myeloid NN cord-010092-uftc8inx 9156 29 leukemia leukemia NN cord-010092-uftc8inx 9156 30 in in IN cord-010092-uftc8inx 9156 31 218 218 CD cord-010092-uftc8inx 9156 32 , , , cord-010092-uftc8inx 9156 33 aplastic aplastic JJ cord-010092-uftc8inx 9156 34 anemia anemia NN cord-010092-uftc8inx 9156 35 in in IN cord-010092-uftc8inx 9156 36 147 147 CD cord-010092-uftc8inx 9156 37 , , , cord-010092-uftc8inx 9156 38 hemophilia hemophilia NN cord-010092-uftc8inx 9156 39 in in IN cord-010092-uftc8inx 9156 40 105 105 CD cord-010092-uftc8inx 9156 41 , , , cord-010092-uftc8inx 9156 42 myelodysplastic myelodysplastic JJ cord-010092-uftc8inx 9156 43 syndrome syndrome NN cord-010092-uftc8inx 9156 44 in in IN cord-010092-uftc8inx 9156 45 73 73 CD cord-010092-uftc8inx 9156 46 , , , cord-010092-uftc8inx 9156 47 and and CC cord-010092-uftc8inx 9156 48 other other JJ cord-010092-uftc8inx 9156 49 hematological hematological JJ cord-010092-uftc8inx 9156 50 diseases disease NNS cord-010092-uftc8inx 9156 51 in in IN cord-010092-uftc8inx 9156 52 1031 1031 CD cord-010092-uftc8inx 9156 53 . . . cord-010092-uftc8inx 9157 1 The the DT cord-010092-uftc8inx 9157 2 frequency frequency NN cord-010092-uftc8inx 9157 3 of of IN cord-010092-uftc8inx 9157 4 detection detection NN cord-010092-uftc8inx 9157 5 of of IN cord-010092-uftc8inx 9157 6 antibodies antibody NNS cord-010092-uftc8inx 9157 7 to to IN cord-010092-uftc8inx 9157 8 antigen antigen NNP cord-010092-uftc8inx 9157 9 C C NNP cord-010092-uftc8inx 9157 10 ( ( -LRB- cord-010092-uftc8inx 9157 11 0.25 0.25 CD cord-010092-uftc8inx 9157 12 % % NN cord-010092-uftc8inx 9157 13 vs vs IN cord-010092-uftc8inx 9157 14 0.06 0.06 CD cord-010092-uftc8inx 9157 15 % % NN cord-010092-uftc8inx 9157 16 ) ) -RRB- cord-010092-uftc8inx 9157 17 and and CC cord-010092-uftc8inx 9157 18 to to IN cord-010092-uftc8inx 9157 19 antigen antigen NN cord-010092-uftc8inx 9157 20 E E NNP cord-010092-uftc8inx 9157 21 ( ( -LRB- cord-010092-uftc8inx 9157 22 0.46 0.46 CD cord-010092-uftc8inx 9157 23 % % NN cord-010092-uftc8inx 9157 24 vs vs IN cord-010092-uftc8inx 9157 25 0.12 0.12 CD cord-010092-uftc8inx 9157 26 % % NN cord-010092-uftc8inx 9157 27 ) ) -RRB- cord-010092-uftc8inx 9157 28 decreased decrease VBD cord-010092-uftc8inx 9157 29 four four CD cord-010092-uftc8inx 9157 30 times time NNS cord-010092-uftc8inx 9157 31 . . . cord-010092-uftc8inx 9158 1 The the DT cord-010092-uftc8inx 9158 2 frequency frequency NN cord-010092-uftc8inx 9158 3 of of IN cord-010092-uftc8inx 9158 4 detection detection NN cord-010092-uftc8inx 9158 5 of of IN cord-010092-uftc8inx 9158 6 antibodies antibody NNS cord-010092-uftc8inx 9158 7 to to IN cord-010092-uftc8inx 9158 8 the the DT cord-010092-uftc8inx 9158 9 C C NNP cord-010092-uftc8inx 9158 10 W W NNP cord-010092-uftc8inx 9158 11 antigen antigen NN cord-010092-uftc8inx 9158 12 has have VBZ cord-010092-uftc8inx 9158 13 not not RB cord-010092-uftc8inx 9158 14 changed change VBN cord-010092-uftc8inx 9158 15 significantly significantly RB cord-010092-uftc8inx 9158 16 ( ( -LRB- cord-010092-uftc8inx 9158 17 0.10 0.10 CD cord-010092-uftc8inx 9158 18 % % NN cord-010092-uftc8inx 9158 19 vs vs IN cord-010092-uftc8inx 9158 20 0.06 0.06 CD cord-010092-uftc8inx 9158 21 % % NN cord-010092-uftc8inx 9158 22 , , , cord-010092-uftc8inx 9158 23 respectively respectively RB cord-010092-uftc8inx 9158 24 ) ) -RRB- cord-010092-uftc8inx 9158 25 . . . cord-010092-uftc8inx 9159 1 Selection selection NN cord-010092-uftc8inx 9159 2 of of IN cord-010092-uftc8inx 9159 3 antigens antigen NNS cord-010092-uftc8inx 9159 4 c c NN cord-010092-uftc8inx 9159 5 ( ( -LRB- cord-010092-uftc8inx 9159 6 Rhesus Rhesus NNP cord-010092-uftc8inx 9159 7 ) ) -RRB- cord-010092-uftc8inx 9159 8 and and CC cord-010092-uftc8inx 9159 9 K K NNP cord-010092-uftc8inx 9159 10 ( ( -LRB- cord-010092-uftc8inx 9159 11 Kell Kell NNP cord-010092-uftc8inx 9159 12 ) ) -RRB- cord-010092-uftc8inx 9159 13 has have VBZ cord-010092-uftc8inx 9159 14 been be VBN cord-010092-uftc8inx 9159 15 carried carry VBN cord-010092-uftc8inx 9159 16 out out RP cord-010092-uftc8inx 9159 17 in in IN cord-010092-uftc8inx 9159 18 the the DT cord-010092-uftc8inx 9159 19 clinic clinic NN cord-010092-uftc8inx 9159 20 since since IN cord-010092-uftc8inx 9159 21 1998 1998 CD cord-010092-uftc8inx 9159 22 , , , cord-010092-uftc8inx 9159 23 therefore therefore RB cord-010092-uftc8inx 9159 24 the the DT cord-010092-uftc8inx 9159 25 immunization immunization NN cord-010092-uftc8inx 9159 26 index index NN cord-010092-uftc8inx 9159 27 for for IN cord-010092-uftc8inx 9159 28 these these DT cord-010092-uftc8inx 9159 29 antigens antigen NNS cord-010092-uftc8inx 9159 30 remained remain VBD cord-010092-uftc8inx 9159 31 unchanged unchanged JJ cord-010092-uftc8inx 9159 32 and and CC cord-010092-uftc8inx 9159 33 amounted amount VBD cord-010092-uftc8inx 9159 34 to to IN cord-010092-uftc8inx 9159 35 0.10 0.10 CD cord-010092-uftc8inx 9159 36 % % NN cord-010092-uftc8inx 9159 37 vs vs IN cord-010092-uftc8inx 9159 38 0.12 0.12 CD cord-010092-uftc8inx 9159 39 % % NN cord-010092-uftc8inx 9159 40 for for IN cord-010092-uftc8inx 9159 41 anti anti JJ cord-010092-uftc8inx 9159 42 - - JJ cord-010092-uftc8inx 9159 43 c c JJ cord-010092-uftc8inx 9159 44 antibodies antibody NNS cord-010092-uftc8inx 9159 45 ; ; : cord-010092-uftc8inx 9159 46 0.36 0.36 CD cord-010092-uftc8inx 9159 47 % % NN cord-010092-uftc8inx 9159 48 vs vs IN cord-010092-uftc8inx 9159 49 0.36%for 0.36%for CD cord-010092-uftc8inx 9159 50 anti anti JJ cord-010092-uftc8inx 9159 51 - - JJ cord-010092-uftc8inx 9159 52 K k JJ cord-010092-uftc8inx 9159 53 antibodies antibody NNS cord-010092-uftc8inx 9159 54 . . . cord-010092-uftc8inx 9160 1 Alloantibodies alloantibody NNS cord-010092-uftc8inx 9160 2 to to IN cord-010092-uftc8inx 9160 3 the the DT cord-010092-uftc8inx 9160 4 antigens antigen NNS cord-010092-uftc8inx 9160 5 e e NN cord-010092-uftc8inx 9160 6 ( ( -LRB- cord-010092-uftc8inx 9160 7 Rhesus Rhesus NNP cord-010092-uftc8inx 9160 8 ) ) -RRB- cord-010092-uftc8inx 9160 9 and and CC cord-010092-uftc8inx 9160 10 k k NNP cord-010092-uftc8inx 9160 11 ( ( -LRB- cord-010092-uftc8inx 9160 12 Kell Kell NNP cord-010092-uftc8inx 9160 13 ) ) -RRB- cord-010092-uftc8inx 9160 14 were be VBD cord-010092-uftc8inx 9160 15 not not RB cord-010092-uftc8inx 9160 16 detected detect VBN cord-010092-uftc8inx 9160 17 for for IN cord-010092-uftc8inx 9160 18 the the DT cord-010092-uftc8inx 9160 19 entire entire JJ cord-010092-uftc8inx 9160 20 observation observation NN cord-010092-uftc8inx 9160 21 period period NN cord-010092-uftc8inx 9160 22 . . . cord-010092-uftc8inx 9161 1 Summary Summary NNP cord-010092-uftc8inx 9161 2 / / SYM cord-010092-uftc8inx 9161 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 9161 4 : : : cord-010092-uftc8inx 9162 1 Research research NN cord-010092-uftc8inx 9162 2 verified verify VBD cord-010092-uftc8inx 9162 3 the the DT cord-010092-uftc8inx 9162 4 effectiveness effectiveness NN cord-010092-uftc8inx 9162 5 of of IN cord-010092-uftc8inx 9162 6 alloimmunization alloimmunization NN cord-010092-uftc8inx 9162 7 prevention prevention NN cord-010092-uftc8inx 9162 8 of of IN cord-010092-uftc8inx 9162 9 recipients recipient NNS cord-010092-uftc8inx 9162 10 by by IN cord-010092-uftc8inx 9162 11 selecting select VBG cord-010092-uftc8inx 9162 12 red red JJ cord-010092-uftc8inx 9162 13 blood blood NN cord-010092-uftc8inx 9162 14 cell cell NN cord-010092-uftc8inx 9162 15 for for IN cord-010092-uftc8inx 9162 16 antigens antigen NNS cord-010092-uftc8inx 9162 17 C C NNP cord-010092-uftc8inx 9162 18 , , , cord-010092-uftc8inx 9162 19 c c NNP cord-010092-uftc8inx 9162 20 , , , cord-010092-uftc8inx 9162 21 E E NNP cord-010092-uftc8inx 9162 22 of of IN cord-010092-uftc8inx 9162 23 the the DT cord-010092-uftc8inx 9162 24 Rhesus Rhesus NNP cord-010092-uftc8inx 9162 25 system system NN cord-010092-uftc8inx 9162 26 and and CC cord-010092-uftc8inx 9162 27 K K NNP cord-010092-uftc8inx 9162 28 ( ( -LRB- cord-010092-uftc8inx 9162 29 Kell Kell NNP cord-010092-uftc8inx 9162 30 ) ) -RRB- cord-010092-uftc8inx 9162 31 . . . cord-010092-uftc8inx 9163 1 The the DT cord-010092-uftc8inx 9163 2 study study NN cord-010092-uftc8inx 9163 3 concluded conclude VBD cord-010092-uftc8inx 9163 4 that that IN cord-010092-uftc8inx 9163 5 selection selection NN cord-010092-uftc8inx 9163 6 of of IN cord-010092-uftc8inx 9163 7 red red JJ cord-010092-uftc8inx 9163 8 blood blood NN cord-010092-uftc8inx 9163 9 cells cell NNS cord-010092-uftc8inx 9163 10 for for IN cord-010092-uftc8inx 9163 11 the the DT cord-010092-uftc8inx 9163 12 antigens antigen NNS cord-010092-uftc8inx 9163 13 C C NNP cord-010092-uftc8inx 9163 14 W W NNP cord-010092-uftc8inx 9163 15 , , , cord-010092-uftc8inx 9163 16 e e LS cord-010092-uftc8inx 9163 17 ( ( -LRB- cord-010092-uftc8inx 9163 18 Rhesus Rhesus NNP cord-010092-uftc8inx 9163 19 ) ) -RRB- cord-010092-uftc8inx 9163 20 and and CC cord-010092-uftc8inx 9163 21 k k NNP cord-010092-uftc8inx 9163 22 ( ( -LRB- cord-010092-uftc8inx 9163 23 Kell Kell NNP cord-010092-uftc8inx 9163 24 ) ) -RRB- cord-010092-uftc8inx 9163 25 does do VBZ cord-010092-uftc8inx 9163 26 not not RB cord-010092-uftc8inx 9163 27 affect affect VB cord-010092-uftc8inx 9163 28 the the DT cord-010092-uftc8inx 9163 29 level level NN cord-010092-uftc8inx 9163 30 of of IN cord-010092-uftc8inx 9163 31 alloimmunization alloimmunization NN cord-010092-uftc8inx 9163 32 of of IN cord-010092-uftc8inx 9163 33 patients patient NNS cord-010092-uftc8inx 9163 34 and and CC cord-010092-uftc8inx 9163 35 is be VBZ cord-010092-uftc8inx 9163 36 not not RB cord-010092-uftc8inx 9163 37 clinically clinically RB cord-010092-uftc8inx 9163 38 justified justified JJ cord-010092-uftc8inx 9163 39 . . . cord-010092-uftc8inx 9164 1 Background background NN cord-010092-uftc8inx 9164 2 : : : cord-010092-uftc8inx 9165 1 In in IN cord-010092-uftc8inx 9165 2 the the DT cord-010092-uftc8inx 9165 3 Russian Russian NNP cord-010092-uftc8inx 9165 4 Federation Federation NNP cord-010092-uftc8inx 9165 5 , , , cord-010092-uftc8inx 9165 6 there there EX cord-010092-uftc8inx 9165 7 is be VBZ cord-010092-uftc8inx 9165 8 an an DT cord-010092-uftc8inx 9165 9 order order NN cord-010092-uftc8inx 9165 10 according accord VBG cord-010092-uftc8inx 9165 11 to to IN cord-010092-uftc8inx 9165 12 which which WDT cord-010092-uftc8inx 9165 13 patients patient NNS cord-010092-uftc8inx 9165 14 requiring require VBG cord-010092-uftc8inx 9165 15 multiple multiple JJ cord-010092-uftc8inx 9165 16 transfusions transfusion NNS cord-010092-uftc8inx 9165 17 , , , cord-010092-uftc8inx 9165 18 who who WP cord-010092-uftc8inx 9165 19 are be VBP cord-010092-uftc8inx 9165 20 at at IN cord-010092-uftc8inx 9165 21 high high JJ cord-010092-uftc8inx 9165 22 risk risk NN cord-010092-uftc8inx 9165 23 of of IN cord-010092-uftc8inx 9165 24 immunological immunological JJ cord-010092-uftc8inx 9165 25 complications complication NNS cord-010092-uftc8inx 9165 26 are be VBP cord-010092-uftc8inx 9165 27 to to TO cord-010092-uftc8inx 9165 28 typed type VBN cord-010092-uftc8inx 9165 29 for for IN cord-010092-uftc8inx 9165 30 red red JJ cord-010092-uftc8inx 9165 31 blood blood NN cord-010092-uftc8inx 9165 32 cell cell NN cord-010092-uftc8inx 9165 33 antigens antigen NNS cord-010092-uftc8inx 9165 34 : : : cord-010092-uftc8inx 9165 35 ABO ABO NNP cord-010092-uftc8inx 9165 36 , , , cord-010092-uftc8inx 9165 37 D D NNP cord-010092-uftc8inx 9165 38 , , , cord-010092-uftc8inx 9165 39 C C NNP cord-010092-uftc8inx 9165 40 , , , cord-010092-uftc8inx 9165 41 c c NNP cord-010092-uftc8inx 9165 42 , , , cord-010092-uftc8inx 9165 43 E E NNP cord-010092-uftc8inx 9165 44 , , , cord-010092-uftc8inx 9165 45 e e NNP cord-010092-uftc8inx 9165 46 , , , cord-010092-uftc8inx 9165 47 Cw Cw NNP cord-010092-uftc8inx 9165 48 , , , cord-010092-uftc8inx 9165 49 K K NNP cord-010092-uftc8inx 9165 50 , , , cord-010092-uftc8inx 9165 51 k. k. NNP cord-010092-uftc8inx 9165 52 Selection Selection NNP cord-010092-uftc8inx 9165 53 of of IN cord-010092-uftc8inx 9165 54 erythrocyte erythrocyte NN cord-010092-uftc8inx 9165 55 - - HYPH cord-010092-uftc8inx 9165 56 containing contain VBG cord-010092-uftc8inx 9165 57 blood blood NN cord-010092-uftc8inx 9165 58 components component NNS cord-010092-uftc8inx 9165 59 is be VBZ cord-010092-uftc8inx 9165 60 carried carry VBN cord-010092-uftc8inx 9165 61 out out RP cord-010092-uftc8inx 9165 62 taking take VBG cord-010092-uftc8inx 9165 63 into into IN cord-010092-uftc8inx 9165 64 account account NN cord-010092-uftc8inx 9165 65 the the DT cord-010092-uftc8inx 9165 66 donorrecipient donorrecipient NN cord-010092-uftc8inx 9165 67 compatibility compatibility NN cord-010092-uftc8inx 9165 68 according accord VBG cord-010092-uftc8inx 9165 69 to to IN cord-010092-uftc8inx 9165 70 all all PDT cord-010092-uftc8inx 9165 71 the the DT cord-010092-uftc8inx 9165 72 listed list VBN cord-010092-uftc8inx 9165 73 antigens antigen NNS cord-010092-uftc8inx 9165 74 . . . cord-010092-uftc8inx 9166 1 Aims aim VBZ cord-010092-uftc8inx 9166 2 : : : cord-010092-uftc8inx 9166 3 Analysis analysis NN cord-010092-uftc8inx 9166 4 of of IN cord-010092-uftc8inx 9166 5 results result NNS cord-010092-uftc8inx 9166 6 of of IN cord-010092-uftc8inx 9166 7 immunological immunological JJ cord-010092-uftc8inx 9166 8 evaluation evaluation NN cord-010092-uftc8inx 9166 9 of of IN cord-010092-uftc8inx 9166 10 patients patient NNS cord-010092-uftc8inx 9166 11 of of IN cord-010092-uftc8inx 9166 12 hematological hematological JJ cord-010092-uftc8inx 9166 13 clinic clinic NN cord-010092-uftc8inx 9166 14 . . . cord-010092-uftc8inx 9167 1 Methods method NNS cord-010092-uftc8inx 9167 2 : : : cord-010092-uftc8inx 9168 1 The the DT cord-010092-uftc8inx 9168 2 study study NN cord-010092-uftc8inx 9168 3 included include VBD cord-010092-uftc8inx 9168 4 466 466 CD cord-010092-uftc8inx 9168 5 first first JJ cord-010092-uftc8inx 9168 6 time time NN cord-010092-uftc8inx 9168 7 patients patient NNS cord-010092-uftc8inx 9168 8 of of IN cord-010092-uftc8inx 9168 9 hematology hematology NN cord-010092-uftc8inx 9168 10 clinic clinic NN cord-010092-uftc8inx 9168 11 in in IN cord-010092-uftc8inx 9168 12 2017 2017 CD cord-010092-uftc8inx 9168 13 - - SYM cord-010092-uftc8inx 9168 14 2018 2018 CD cord-010092-uftc8inx 9168 15 . . . cord-010092-uftc8inx 9169 1 Typing typing NN cord-010092-uftc8inx 9169 2 of of IN cord-010092-uftc8inx 9169 3 antigens antigen NNS cord-010092-uftc8inx 9169 4 of of IN cord-010092-uftc8inx 9169 5 ABO ABO NNP cord-010092-uftc8inx 9169 6 , , , cord-010092-uftc8inx 9169 7 Rhesus Rhesus NNP cord-010092-uftc8inx 9169 8 , , , cord-010092-uftc8inx 9169 9 Kell Kell NNP cord-010092-uftc8inx 9169 10 systems system NNS cord-010092-uftc8inx 9169 11 , , , cord-010092-uftc8inx 9169 12 screening screening NN cord-010092-uftc8inx 9169 13 and and CC cord-010092-uftc8inx 9169 14 identification identification NN cord-010092-uftc8inx 9169 15 of of IN cord-010092-uftc8inx 9169 16 antibodies antibody NNS cord-010092-uftc8inx 9169 17 were be VBD cord-010092-uftc8inx 9169 18 carried carry VBN cord-010092-uftc8inx 9169 19 out out RP cord-010092-uftc8inx 9169 20 using use VBG cord-010092-uftc8inx 9169 21 equipment equipment NN cord-010092-uftc8inx 9169 22 and and CC cord-010092-uftc8inx 9169 23 reagents reagent NNS cord-010092-uftc8inx 9169 24 from from IN cord-010092-uftc8inx 9169 25 Bio Bio NNP cord-010092-uftc8inx 9169 26 Rad Rad NNP cord-010092-uftc8inx 9169 27 ( ( -LRB- cord-010092-uftc8inx 9169 28 USA USA NNP cord-010092-uftc8inx 9169 29 ) ) -RRB- cord-010092-uftc8inx 9169 30 . . . cord-010092-uftc8inx 9170 1 Results result NNS cord-010092-uftc8inx 9170 2 : : : cord-010092-uftc8inx 9171 1 Interpretation interpretation NN cord-010092-uftc8inx 9171 2 of of IN cord-010092-uftc8inx 9171 3 results result NNS cord-010092-uftc8inx 9171 4 of of IN cord-010092-uftc8inx 9171 5 immunohematological immunohematological JJ cord-010092-uftc8inx 9171 6 screening screening NN cord-010092-uftc8inx 9171 7 was be VBD cord-010092-uftc8inx 9171 8 complicated complicate VBN cord-010092-uftc8inx 9171 9 in in IN cord-010092-uftc8inx 9171 10 84 84 CD cord-010092-uftc8inx 9171 11 ( ( -LRB- cord-010092-uftc8inx 9171 12 18.0 18.0 CD cord-010092-uftc8inx 9171 13 % % NN cord-010092-uftc8inx 9171 14 ) ) -RRB- cord-010092-uftc8inx 9171 15 patients patient NNS cord-010092-uftc8inx 9171 16 . . . cord-010092-uftc8inx 9172 1 The the DT cord-010092-uftc8inx 9172 2 total total JJ cord-010092-uftc8inx 9172 3 number number NN cord-010092-uftc8inx 9172 4 of of IN cord-010092-uftc8inx 9172 5 complex complex JJ cord-010092-uftc8inx 9172 6 cases case NNS cord-010092-uftc8inx 9172 7 was be VBD cord-010092-uftc8inx 9172 8 96 96 CD cord-010092-uftc8inx 9172 9 . . . cord-010092-uftc8inx 9173 1 The the DT cord-010092-uftc8inx 9173 2 double double JJ cord-010092-uftc8inx 9173 3 population population NN cord-010092-uftc8inx 9173 4 of of IN cord-010092-uftc8inx 9173 5 red red JJ cord-010092-uftc8inx 9173 6 blood blood NN cord-010092-uftc8inx 9173 7 cell cell NN cord-010092-uftc8inx 9173 8 was be VBD cord-010092-uftc8inx 9173 9 most most RBS cord-010092-uftc8inx 9173 10 often often RB cord-010092-uftc8inx 9173 11 determined determine VBN cord-010092-uftc8inx 9173 12 in in IN cord-010092-uftc8inx 9173 13 antigens antigen NNS cord-010092-uftc8inx 9173 14 of of IN cord-010092-uftc8inx 9173 15 the the DT cord-010092-uftc8inx 9173 16 Rhesus Rhesus NNP cord-010092-uftc8inx 9173 17 system system NN cord-010092-uftc8inx 9173 18 ( ( -LRB- cord-010092-uftc8inx 9173 19 10.9 10.9 CD cord-010092-uftc8inx 9173 20 % % NN cord-010092-uftc8inx 9173 21 of of IN cord-010092-uftc8inx 9173 22 the the DT cord-010092-uftc8inx 9173 23 total total JJ cord-010092-uftc8inx 9173 24 number number NN cord-010092-uftc8inx 9173 25 of of IN cord-010092-uftc8inx 9173 26 patients patient NNS cord-010092-uftc8inx 9173 27 ) ) -RRB- cord-010092-uftc8inx 9173 28 as as IN cord-010092-uftc8inx 9173 29 a a DT cord-010092-uftc8inx 9173 30 result result NN cord-010092-uftc8inx 9173 31 of of IN cord-010092-uftc8inx 9173 32 previous previous JJ cord-010092-uftc8inx 9173 33 transfusion transfusion NN cord-010092-uftc8inx 9173 34 therapy therapy NN cord-010092-uftc8inx 9173 35 . . . cord-010092-uftc8inx 9174 1 Of of IN cord-010092-uftc8inx 9174 2 those those DT cord-010092-uftc8inx 9174 3 , , , cord-010092-uftc8inx 9174 4 chimera chimera NN cord-010092-uftc8inx 9174 5 for for IN cord-010092-uftc8inx 9174 6 the the DT cord-010092-uftc8inx 9174 7 antigen antigen NN cord-010092-uftc8inx 9174 8 E E NNP cord-010092-uftc8inx 9174 9 was be VBD cord-010092-uftc8inx 9174 10 detected detect VBN cord-010092-uftc8inx 9174 11 in in IN cord-010092-uftc8inx 9174 12 31 31 CD cord-010092-uftc8inx 9174 13 cases case NNS cord-010092-uftc8inx 9174 14 ( ( -LRB- cord-010092-uftc8inx 9174 15 60.8 60.8 CD cord-010092-uftc8inx 9174 16 % % NN cord-010092-uftc8inx 9174 17 of of IN cord-010092-uftc8inx 9174 18 patients patient NNS cord-010092-uftc8inx 9174 19 with with IN cord-010092-uftc8inx 9174 20 the the DT cord-010092-uftc8inx 9174 21 chimera chimera NN cord-010092-uftc8inx 9174 22 for for IN cord-010092-uftc8inx 9174 23 Rhesus Rhesus NNP cord-010092-uftc8inx 9174 24 and and CC cord-010092-uftc8inx 9174 25 Kell Kell NNP cord-010092-uftc8inx 9174 26 antigens antigen NNS cord-010092-uftc8inx 9174 27 ) ) -RRB- cord-010092-uftc8inx 9174 28 , , , cord-010092-uftc8inx 9174 29 Cin Cin NNP cord-010092-uftc8inx 9174 30 23 23 CD cord-010092-uftc8inx 9174 31 ( ( -LRB- cord-010092-uftc8inx 9174 32 45.1 45.1 CD cord-010092-uftc8inx 9174 33 % % NN cord-010092-uftc8inx 9174 34 ) ) -RRB- cord-010092-uftc8inx 9174 35 , , , cord-010092-uftc8inx 9174 36 sin sin VB cord-010092-uftc8inx 9174 37 15 15 CD cord-010092-uftc8inx 9174 38 ( ( -LRB- cord-010092-uftc8inx 9174 39 29.4 29.4 CD cord-010092-uftc8inx 9174 40 % % NN cord-010092-uftc8inx 9174 41 ) ) -RRB- cord-010092-uftc8inx 9174 42 , , , cord-010092-uftc8inx 9174 43 e e LS cord-010092-uftc8inx 9174 44 -5 -5 NNP cord-010092-uftc8inx 9174 45 ( ( -LRB- cord-010092-uftc8inx 9174 46 9.8 9.8 CD cord-010092-uftc8inx 9174 47 % % NN cord-010092-uftc8inx 9174 48 ) ) -RRB- cord-010092-uftc8inx 9174 49 , , , cord-010092-uftc8inx 9174 50 Cw Cw NNP cord-010092-uftc8inx 9174 51 -8 -8 NNP cord-010092-uftc8inx 9174 52 ( ( -LRB- cord-010092-uftc8inx 9174 53 15.7 15.7 CD cord-010092-uftc8inx 9174 54 % % NN cord-010092-uftc8inx 9174 55 ) ) -RRB- cord-010092-uftc8inx 9174 56 , , , cord-010092-uftc8inx 9174 57 K K NNP cord-010092-uftc8inx 9174 58 -5 -5 NNP cord-010092-uftc8inx 9174 59 ( ( -LRB- cord-010092-uftc8inx 9174 60 9.8 9.8 CD cord-010092-uftc8inx 9174 61 % % NN cord-010092-uftc8inx 9174 62 ) ) -RRB- cord-010092-uftc8inx 9174 63 . . . cord-010092-uftc8inx 9175 1 In in IN cord-010092-uftc8inx 9175 2 such such JJ cord-010092-uftc8inx 9175 3 cases case NNS cord-010092-uftc8inx 9175 4 , , , cord-010092-uftc8inx 9175 5 donor donor NN cord-010092-uftc8inx 9175 6 red red JJ cord-010092-uftc8inx 9175 7 blood blood NN cord-010092-uftc8inx 9175 8 cells cell NNS cord-010092-uftc8inx 9175 9 were be VBD cord-010092-uftc8inx 9175 10 chosen choose VBN cord-010092-uftc8inx 9175 11 not not RB cord-010092-uftc8inx 9175 12 carrying carry VBG cord-010092-uftc8inx 9175 13 chimeric chimeric JJ cord-010092-uftc8inx 9175 14 antigen antigen NN cord-010092-uftc8inx 9175 15 for for IN cord-010092-uftc8inx 9175 16 transfusions transfusion NNS cord-010092-uftc8inx 9175 17 , , , cord-010092-uftc8inx 9175 18 in in IN cord-010092-uftc8inx 9175 19 the the DT cord-010092-uftc8inx 9175 20 presence presence NN cord-010092-uftc8inx 9175 21 of of IN cord-010092-uftc8inx 9175 22 chimeras chimera NNS cord-010092-uftc8inx 9175 23 in in IN cord-010092-uftc8inx 9175 24 both both DT cord-010092-uftc8inx 9175 25 paired pair VBN cord-010092-uftc8inx 9175 26 antigensred antigensred JJ cord-010092-uftc8inx 9175 27 blood blood NN cord-010092-uftc8inx 9175 28 cell cell NN cord-010092-uftc8inx 9175 29 transfusion transfusion NN cord-010092-uftc8inx 9175 30 with with IN cord-010092-uftc8inx 9175 31 the the DT cord-010092-uftc8inx 9175 32 CC CC NNP cord-010092-uftc8inx 9175 33 phenotype phenotype NN cord-010092-uftc8inx 9175 34 and and CC cord-010092-uftc8inx 9175 35 / / SYM cord-010092-uftc8inx 9175 36 ee ee NNP cord-010092-uftc8inx 9175 37 . . . cord-010092-uftc8inx 9176 1 Chimera Chimera NNP cord-010092-uftc8inx 9176 2 for for IN cord-010092-uftc8inx 9176 3 ABO ABO NNP cord-010092-uftc8inx 9176 4 antigens antigen NNS cord-010092-uftc8inx 9176 5 was be VBD cord-010092-uftc8inx 9176 6 detected detect VBN cord-010092-uftc8inx 9176 7 in in IN cord-010092-uftc8inx 9176 8 0.6 0.6 CD cord-010092-uftc8inx 9176 9 % % NN cord-010092-uftc8inx 9176 10 of of IN cord-010092-uftc8inx 9176 11 the the DT cord-010092-uftc8inx 9176 12 examined examine VBN cord-010092-uftc8inx 9176 13 individuals individual NNS cord-010092-uftc8inx 9176 14 . . . cord-010092-uftc8inx 9177 1 The the DT cord-010092-uftc8inx 9177 2 discrepancy discrepancy NN cord-010092-uftc8inx 9177 3 between between IN cord-010092-uftc8inx 9177 4 the the DT cord-010092-uftc8inx 9177 5 direct direct JJ cord-010092-uftc8inx 9177 6 and and CC cord-010092-uftc8inx 9177 7 reverse reverse VB cord-010092-uftc8inx 9177 8 blood blood NN cord-010092-uftc8inx 9177 9 grouping grouping NN cord-010092-uftc8inx 9177 10 of of IN cord-010092-uftc8inx 9177 11 the the DT cord-010092-uftc8inx 9177 12 ABO ABO NNP cord-010092-uftc8inx 9177 13 system system NN cord-010092-uftc8inx 9177 14 in in IN cord-010092-uftc8inx 9177 15 patients patient NNS cord-010092-uftc8inx 9177 16 ( ( -LRB- cord-010092-uftc8inx 9177 17 1.1 1.1 CD cord-010092-uftc8inx 9177 18 % % NN cord-010092-uftc8inx 9177 19 ) ) -RRB- cord-010092-uftc8inx 9177 20 was be VBD cord-010092-uftc8inx 9177 21 due due JJ cord-010092-uftc8inx 9177 22 to to IN cord-010092-uftc8inx 9177 23 a a DT cord-010092-uftc8inx 9177 24 decrease decrease NN cord-010092-uftc8inx 9177 25 in in IN cord-010092-uftc8inx 9177 26 the the DT cord-010092-uftc8inx 9177 27 production production NN cord-010092-uftc8inx 9177 28 of of IN cord-010092-uftc8inx 9177 29 antibodies antibody NNS cord-010092-uftc8inx 9177 30 -4 -4 : cord-010092-uftc8inx 9177 31 cases case NNS cord-010092-uftc8inx 9177 32 and and CC cord-010092-uftc8inx 9177 33 the the DT cord-010092-uftc8inx 9177 34 appearance appearance NN cord-010092-uftc8inx 9177 35 of of IN cord-010092-uftc8inx 9177 36 extra extra JJ cord-010092-uftc8inx 9177 37 agglutinins agglutinin NNS cord-010092-uftc8inx 9177 38 -1 -1 NNP cord-010092-uftc8inx 9177 39 case case NN cord-010092-uftc8inx 9177 40 . . . cord-010092-uftc8inx 9178 1 Autoantibodies Autoantibodies NNP cord-010092-uftc8inx 9178 2 were be VBD cord-010092-uftc8inx 9178 3 detected detect VBN cord-010092-uftc8inx 9178 4 in in IN cord-010092-uftc8inx 9178 5 3.9 3.9 CD cord-010092-uftc8inx 9178 6 % % NN cord-010092-uftc8inx 9178 7 of of IN cord-010092-uftc8inx 9178 8 all all DT cord-010092-uftc8inx 9178 9 patients patient NNS cord-010092-uftc8inx 9178 10 , , , cord-010092-uftc8inx 9178 11 including include VBG cord-010092-uftc8inx 9178 12 0.6 0.6 CD cord-010092-uftc8inx 9178 13 % % NN cord-010092-uftc8inx 9178 14 of of IN cord-010092-uftc8inx 9178 15 patients patient NNS cord-010092-uftc8inx 9178 16 , , , cord-010092-uftc8inx 9178 17 when when WRB cord-010092-uftc8inx 9178 18 they -PRON- PRP cord-010092-uftc8inx 9178 19 caused cause VBD cord-010092-uftc8inx 9178 20 panagglutination panagglutination NN cord-010092-uftc8inx 9178 21 phenomenon phenomenon NN cord-010092-uftc8inx 9178 22 . . . cord-010092-uftc8inx 9179 1 Upon upon IN cord-010092-uftc8inx 9179 2 detection detection NN cord-010092-uftc8inx 9179 3 of of IN cord-010092-uftc8inx 9179 4 autoantibodies autoantibody NNS cord-010092-uftc8inx 9179 5 that that WDT cord-010092-uftc8inx 9179 6 complicate complicate VBP cord-010092-uftc8inx 9179 7 the the DT cord-010092-uftc8inx 9179 8 individual individual JJ cord-010092-uftc8inx 9179 9 selection selection NN cord-010092-uftc8inx 9179 10 of of IN cord-010092-uftc8inx 9179 11 donors donor NNS cord-010092-uftc8inx 9179 12 , , , cord-010092-uftc8inx 9179 13 transfused transfuse VBD cord-010092-uftc8inx 9179 14 red red JJ cord-010092-uftc8inx 9179 15 blood blood NN cord-010092-uftc8inx 9179 16 cells cell NNS cord-010092-uftc8inx 9179 17 that that WDT cord-010092-uftc8inx 9179 18 are be VBP cord-010092-uftc8inx 9179 19 compatible compatible JJ cord-010092-uftc8inx 9179 20 with with IN cord-010092-uftc8inx 9179 21 antigens antigen NNS cord-010092-uftc8inx 9179 22 of of IN cord-010092-uftc8inx 9179 23 ABO ABO NNP cord-010092-uftc8inx 9179 24 , , , cord-010092-uftc8inx 9179 25 Rhesus Rhesus NNP cord-010092-uftc8inx 9179 26 , , , cord-010092-uftc8inx 9179 27 Kell Kell NNP cord-010092-uftc8inx 9179 28 , , , cord-010092-uftc8inx 9179 29 Duffy Duffy NNP cord-010092-uftc8inx 9179 30 , , , cord-010092-uftc8inx 9179 31 Kidd Kidd NNP cord-010092-uftc8inx 9179 32 , , , cord-010092-uftc8inx 9179 33 MNS MNS NNP cord-010092-uftc8inx 9179 34 systems system NNS cord-010092-uftc8inx 9179 35 . . . cord-010092-uftc8inx 9180 1 Alloantibodies alloantibody NNS cord-010092-uftc8inx 9180 2 were be VBD cord-010092-uftc8inx 9180 3 detected detect VBN cord-010092-uftc8inx 9180 4 in in IN cord-010092-uftc8inx 9180 5 2.8 2.8 CD cord-010092-uftc8inx 9180 6 % % NN cord-010092-uftc8inx 9180 7 of of IN cord-010092-uftc8inx 9180 8 patients patient NNS cord-010092-uftc8inx 9180 9 , , , cord-010092-uftc8inx 9180 10 including include VBG cord-010092-uftc8inx 9180 11 specific specific JJ cord-010092-uftc8inx 9180 12 anti anti JJ cord-010092-uftc8inx 9180 13 - - JJ cord-010092-uftc8inx 9180 14 Din Din NNP cord-010092-uftc8inx 9180 15 4 4 CD cord-010092-uftc8inx 9180 16 ( ( -LRB- cord-010092-uftc8inx 9180 17 0.86 0.86 CD cord-010092-uftc8inx 9180 18 % % NN cord-010092-uftc8inx 9180 19 ) ) -RRB- cord-010092-uftc8inx 9180 20 , , , cord-010092-uftc8inx 9180 21 anti anti JJ cord-010092-uftc8inx 9180 22 - - JJ cord-010092-uftc8inx 9180 23 DCin DCin NNP cord-010092-uftc8inx 9180 24 2 2 CD cord-010092-uftc8inx 9180 25 ( ( -LRB- cord-010092-uftc8inx 9180 26 0.43 0.43 CD cord-010092-uftc8inx 9180 27 % % NN cord-010092-uftc8inx 9180 28 ) ) -RRB- cord-010092-uftc8inx 9180 29 , , , cord-010092-uftc8inx 9180 30 anti anti JJ cord-010092-uftc8inx 9180 31 - - NNP cord-010092-uftc8inx 9180 32 Kin Kin NNP cord-010092-uftc8inx 9180 33 1 1 CD cord-010092-uftc8inx 9180 34 ( ( -LRB- cord-010092-uftc8inx 9180 35 0.21 0.21 CD cord-010092-uftc8inx 9180 36 % % NN cord-010092-uftc8inx 9180 37 ) ) -RRB- cord-010092-uftc8inx 9180 38 ; ; : cord-010092-uftc8inx 9180 39 antibodies antibody NNS cord-010092-uftc8inx 9180 40 of of IN cord-010092-uftc8inx 9180 41 unidentified unidentified JJ cord-010092-uftc8inx 9180 42 specificityin specificityin NNP cord-010092-uftc8inx 9180 43 2 2 CD cord-010092-uftc8inx 9180 44 ( ( -LRB- cord-010092-uftc8inx 9180 45 0.43 0.43 CD cord-010092-uftc8inx 9180 46 % % NN cord-010092-uftc8inx 9180 47 ) ) -RRB- cord-010092-uftc8inx 9180 48 , , , cord-010092-uftc8inx 9180 49 polyspecificin polyspecificin NNP cord-010092-uftc8inx 9180 50 4 4 CD cord-010092-uftc8inx 9180 51 ( ( -LRB- cord-010092-uftc8inx 9180 52 0.86 0.86 CD cord-010092-uftc8inx 9180 53 % % NN cord-010092-uftc8inx 9180 54 ) ) -RRB- cord-010092-uftc8inx 9180 55 . . . cord-010092-uftc8inx 9181 1 Summary Summary NNP cord-010092-uftc8inx 9181 2 / / SYM cord-010092-uftc8inx 9181 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 9181 4 : : : cord-010092-uftc8inx 9182 1 The the DT cord-010092-uftc8inx 9182 2 complexity complexity NN cord-010092-uftc8inx 9182 3 of of IN cord-010092-uftc8inx 9182 4 interpreting interpret VBG cord-010092-uftc8inx 9182 5 immuno immuno JJ cord-010092-uftc8inx 9182 6 - - HYPH cord-010092-uftc8inx 9182 7 hematological hematological JJ cord-010092-uftc8inx 9182 8 tests test NNS cord-010092-uftc8inx 9182 9 in in IN cord-010092-uftc8inx 9182 10 hematological hematological JJ cord-010092-uftc8inx 9182 11 patients patient NNS cord-010092-uftc8inx 9182 12 is be VBZ cord-010092-uftc8inx 9182 13 due due JJ cord-010092-uftc8inx 9182 14 to to IN cord-010092-uftc8inx 9182 15 intensive intensive JJ cord-010092-uftc8inx 9182 16 transfusion transfusion NN cord-010092-uftc8inx 9182 17 therapy therapy NN cord-010092-uftc8inx 9182 18 , , , cord-010092-uftc8inx 9182 19 changes change NNS cord-010092-uftc8inx 9182 20 in in IN cord-010092-uftc8inx 9182 21 red red JJ cord-010092-uftc8inx 9182 22 blood blood NN cord-010092-uftc8inx 9182 23 cell cell NN cord-010092-uftc8inx 9182 24 antigens antigen NNS cord-010092-uftc8inx 9182 25 and and CC cord-010092-uftc8inx 9182 26 appearance appearance NN cord-010092-uftc8inx 9182 27 of of IN cord-010092-uftc8inx 9182 28 nonspecific nonspecific JJ cord-010092-uftc8inx 9182 29 antibodies antibody NNS cord-010092-uftc8inx 9182 30 due due JJ cord-010092-uftc8inx 9182 31 to to IN cord-010092-uftc8inx 9182 32 underlying underlying JJ cord-010092-uftc8inx 9182 33 disease disease NN cord-010092-uftc8inx 9182 34 . . . cord-010092-uftc8inx 9183 1 Red red JJ cord-010092-uftc8inx 9183 2 blood blood NN cord-010092-uftc8inx 9183 3 cell cell NN cord-010092-uftc8inx 9183 4 for for IN cord-010092-uftc8inx 9183 5 transfusion transfusion NN cord-010092-uftc8inx 9183 6 in in IN cord-010092-uftc8inx 9183 7 these these DT cord-010092-uftc8inx 9183 8 patients patient NNS cord-010092-uftc8inx 9183 9 should should MD cord-010092-uftc8inx 9183 10 be be VB cord-010092-uftc8inx 9183 11 selected select VBN cord-010092-uftc8inx 9183 12 taking take VBG cord-010092-uftc8inx 9183 13 into into IN cord-010092-uftc8inx 9183 14 account account NN cord-010092-uftc8inx 9183 15 the the DT cord-010092-uftc8inx 9183 16 expanded expand VBN cord-010092-uftc8inx 9183 17 red red JJ cord-010092-uftc8inx 9183 18 blood blood NN cord-010092-uftc8inx 9183 19 cell cell NN cord-010092-uftc8inx 9183 20 antigen antigen NN cord-010092-uftc8inx 9183 21 profile profile NN cord-010092-uftc8inx 9183 22 . . . cord-010092-uftc8inx 9184 1 Abstract Abstract NNP cord-010092-uftc8inx 9184 2 withdrawn withdraw VBN cord-010092-uftc8inx 9184 3 . . . cord-010092-uftc8inx 9185 1 Background background NN cord-010092-uftc8inx 9185 2 : : : cord-010092-uftc8inx 9186 1 Blood blood NN cord-010092-uftc8inx 9186 2 transfusion transfusion NN cord-010092-uftc8inx 9186 3 is be VBZ cord-010092-uftc8inx 9186 4 an an DT cord-010092-uftc8inx 9186 5 essential essential JJ cord-010092-uftc8inx 9186 6 part part NN cord-010092-uftc8inx 9186 7 of of IN cord-010092-uftc8inx 9186 8 therapy therapy NN cord-010092-uftc8inx 9186 9 for for IN cord-010092-uftc8inx 9186 10 many many JJ cord-010092-uftc8inx 9186 11 patients patient NNS cord-010092-uftc8inx 9186 12 . . . cord-010092-uftc8inx 9187 1 Although although IN cord-010092-uftc8inx 9187 2 life life NN cord-010092-uftc8inx 9187 3 - - HYPH cord-010092-uftc8inx 9187 4 saving save VBG cord-010092-uftc8inx 9187 5 for for IN cord-010092-uftc8inx 9187 6 many many JJ cord-010092-uftc8inx 9187 7 patients patient NNS cord-010092-uftc8inx 9187 8 , , , cord-010092-uftc8inx 9187 9 blood blood NN cord-010092-uftc8inx 9187 10 transfusion transfusion NN cord-010092-uftc8inx 9187 11 is be VBZ cord-010092-uftc8inx 9187 12 not not RB cord-010092-uftc8inx 9187 13 without without IN cord-010092-uftc8inx 9187 14 risk risk NN cord-010092-uftc8inx 9187 15 . . . cord-010092-uftc8inx 9188 1 The the DT cord-010092-uftc8inx 9188 2 main main JJ cord-010092-uftc8inx 9188 3 goal goal NN cord-010092-uftc8inx 9188 4 of of IN cord-010092-uftc8inx 9188 5 blood blood NN cord-010092-uftc8inx 9188 6 transfusion transfusion NN cord-010092-uftc8inx 9188 7 services service NNS cord-010092-uftc8inx 9188 8 is be VBZ cord-010092-uftc8inx 9188 9 that that IN cord-010092-uftc8inx 9188 10 transfused transfuse VBN cord-010092-uftc8inx 9188 11 blood blood NN cord-010092-uftc8inx 9188 12 should should MD cord-010092-uftc8inx 9188 13 be be VB cord-010092-uftc8inx 9188 14 compatible compatible JJ cord-010092-uftc8inx 9188 15 with with IN cord-010092-uftc8inx 9188 16 the the DT cord-010092-uftc8inx 9188 17 patient patient NN cord-010092-uftc8inx 9188 18 . . . cord-010092-uftc8inx 9189 1 The the DT cord-010092-uftc8inx 9189 2 clinical clinical JJ cord-010092-uftc8inx 9189 3 and and CC cord-010092-uftc8inx 9189 4 serologic serologic JJ cord-010092-uftc8inx 9189 5 evaluation evaluation NN cord-010092-uftc8inx 9189 6 , , , cord-010092-uftc8inx 9189 7 which which WDT cord-010092-uftc8inx 9189 8 allows allow VBZ cord-010092-uftc8inx 9189 9 for for IN cord-010092-uftc8inx 9189 10 the the DT cord-010092-uftc8inx 9189 11 transfusion transfusion NN cord-010092-uftc8inx 9189 12 of of IN cord-010092-uftc8inx 9189 13 the the DT cord-010092-uftc8inx 9189 14 most most RBS cord-010092-uftc8inx 9189 15 compatible compatible JJ cord-010092-uftc8inx 9189 16 ( ( -LRB- cord-010092-uftc8inx 9189 17 or or CC cord-010092-uftc8inx 9189 18 " " `` cord-010092-uftc8inx 9189 19 least least JJS cord-010092-uftc8inx 9189 20 incompatible incompatible JJ cord-010092-uftc8inx 9189 21 " " '' cord-010092-uftc8inx 9189 22 ) ) -RRB- cord-010092-uftc8inx 9189 23 blood blood NN cord-010092-uftc8inx 9189 24 , , , cord-010092-uftc8inx 9189 25 requires require VBZ cord-010092-uftc8inx 9189 26 a a DT cord-010092-uftc8inx 9189 27 joint joint JJ cord-010092-uftc8inx 9189 28 effort effort NN cord-010092-uftc8inx 9189 29 between between IN cord-010092-uftc8inx 9189 30 the the DT cord-010092-uftc8inx 9189 31 clinician clinician NN cord-010092-uftc8inx 9189 32 and and CC cord-010092-uftc8inx 9189 33 the the DT cord-010092-uftc8inx 9189 34 transfusion transfusion NN cord-010092-uftc8inx 9189 35 medicine medicine NN cord-010092-uftc8inx 9189 36 physician physician NN cord-010092-uftc8inx 9189 37 . . . cord-010092-uftc8inx 9190 1 Aims aim VBZ cord-010092-uftc8inx 9190 2 : : : cord-010092-uftc8inx 9191 1 Root root NN cord-010092-uftc8inx 9191 2 cause cause VB cord-010092-uftc8inx 9191 3 analysis analysis NN cord-010092-uftc8inx 9191 4 of of IN cord-010092-uftc8inx 9191 5 incompatible incompatible JJ cord-010092-uftc8inx 9191 6 cross cross NN cord-010092-uftc8inx 9191 7 matches match NNS cord-010092-uftc8inx 9191 8 in in IN cord-010092-uftc8inx 9191 9 patients patient NNS cord-010092-uftc8inx 9191 10 . . . cord-010092-uftc8inx 9192 1 Methods method NNS cord-010092-uftc8inx 9192 2 : : : cord-010092-uftc8inx 9192 3 In in IN cord-010092-uftc8inx 9192 4 this this DT cord-010092-uftc8inx 9192 5 prospective prospective JJ cord-010092-uftc8inx 9192 6 study study NN cord-010092-uftc8inx 9192 7 , , , cord-010092-uftc8inx 9192 8 total total NN cord-010092-uftc8inx 9192 9 of of IN cord-010092-uftc8inx 9192 10 3,49,497 3,49,497 CD cord-010092-uftc8inx 9192 11 crossmatches crossmatche NNS cord-010092-uftc8inx 9192 12 were be VBD cord-010092-uftc8inx 9192 13 performed perform VBN cord-010092-uftc8inx 9192 14 over over IN cord-010092-uftc8inx 9192 15 period period NN cord-010092-uftc8inx 9192 16 of of IN cord-010092-uftc8inx 9192 17 last last JJ cord-010092-uftc8inx 9192 18 four four CD cord-010092-uftc8inx 9192 19 & & CC cord-010092-uftc8inx 9192 20 half half NN cord-010092-uftc8inx 9192 21 years year NNS cord-010092-uftc8inx 9192 22 , , , cord-010092-uftc8inx 9192 23 out out IN cord-010092-uftc8inx 9192 24 of of IN cord-010092-uftc8inx 9192 25 which which WDT cord-010092-uftc8inx 9192 26 867 867 CD cord-010092-uftc8inx 9192 27 units unit NNS cord-010092-uftc8inx 9192 28 were be VBD cord-010092-uftc8inx 9192 29 found find VBN cord-010092-uftc8inx 9192 30 incompatible incompatible JJ cord-010092-uftc8inx 9192 31 by by IN cord-010092-uftc8inx 9192 32 column column NN cord-010092-uftc8inx 9192 33 agglutination agglutination NN cord-010092-uftc8inx 9192 34 method method NN cord-010092-uftc8inx 9192 35 - - HYPH cord-010092-uftc8inx 9192 36 CAT cat NN cord-010092-uftc8inx 9192 37 in in IN cord-010092-uftc8inx 9192 38 polyspecific polyspecific NN cord-010092-uftc8inx 9193 1 ( ( -LRB- cord-010092-uftc8inx 9193 2 Anti anti JJ cord-010092-uftc8inx 9193 3 - - JJ cord-010092-uftc8inx 9193 4 IgG+ igg+ JJ cord-010092-uftc8inx 9193 5 C3d C3d NNP cord-010092-uftc8inx 9193 6 ) ) -RRB- cord-010092-uftc8inx 9193 7 gel gel NN cord-010092-uftc8inx 9193 8 media medium NNS cord-010092-uftc8inx 9193 9 . . . cord-010092-uftc8inx 9194 1 A a DT cord-010092-uftc8inx 9194 2 root root NN cord-010092-uftc8inx 9194 3 cause cause NN cord-010092-uftc8inx 9194 4 analysis analysis NN cord-010092-uftc8inx 9194 5 protocol protocol NN cord-010092-uftc8inx 9194 6 was be VBD cord-010092-uftc8inx 9194 7 formulated formulate VBN cord-010092-uftc8inx 9194 8 to to TO cord-010092-uftc8inx 9194 9 resolve resolve VB cord-010092-uftc8inx 9194 10 incompatibility incompatibility NN cord-010092-uftc8inx 9194 11 to to TO cord-010092-uftc8inx 9194 12 ensure ensure VB cord-010092-uftc8inx 9194 13 safe safe JJ cord-010092-uftc8inx 9194 14 transfusion transfusion NN cord-010092-uftc8inx 9194 15 . . . cord-010092-uftc8inx 9195 1 Results result NNS cord-010092-uftc8inx 9195 2 : : : cord-010092-uftc8inx 9196 1 On on IN cord-010092-uftc8inx 9196 2 the the DT cord-010092-uftc8inx 9196 3 evaluation evaluation NN cord-010092-uftc8inx 9196 4 of of IN cord-010092-uftc8inx 9196 5 3,49,497 3,49,497 CD cord-010092-uftc8inx 9196 6 crossmatches crossmatche NNS cord-010092-uftc8inx 9196 7 , , , cord-010092-uftc8inx 9196 8 only only RB cord-010092-uftc8inx 9196 9 867 867 CD cord-010092-uftc8inx 9196 10 units unit NNS cord-010092-uftc8inx 9196 11 were be VBD cord-010092-uftc8inx 9196 12 found find VBN cord-010092-uftc8inx 9196 13 to to TO cord-010092-uftc8inx 9196 14 be be VB cord-010092-uftc8inx 9196 15 incompatible incompatible JJ cord-010092-uftc8inx 9196 16 ( ( -LRB- cord-010092-uftc8inx 9196 17 0.14 0.14 CD cord-010092-uftc8inx 9196 18 % % NN cord-010092-uftc8inx 9196 19 ) ) -RRB- cord-010092-uftc8inx 9196 20 . . . cord-010092-uftc8inx 9197 1 The the DT cord-010092-uftc8inx 9197 2 major major JJ cord-010092-uftc8inx 9197 3 cause cause NN cord-010092-uftc8inx 9197 4 for for IN cord-010092-uftc8inx 9197 5 incompatibility incompatibility NN cord-010092-uftc8inx 9197 6 found find VBN cord-010092-uftc8inx 9197 7 in in IN cord-010092-uftc8inx 9197 8 patients patient NNS cord-010092-uftc8inx 9197 9 was be VBD cord-010092-uftc8inx 9197 10 AIHA-(32.87 AIHA-(32.87 NNP cord-010092-uftc8inx 9197 11 % % NN cord-010092-uftc8inx 9197 12 ) ) -RRB- cord-010092-uftc8inx 9197 13 . . . cord-010092-uftc8inx 9198 1 Other other JJ cord-010092-uftc8inx 9198 2 causes cause NNS cord-010092-uftc8inx 9198 3 of of IN cord-010092-uftc8inx 9198 4 incompatibility incompatibility NN cord-010092-uftc8inx 9198 5 were be VBD cord-010092-uftc8inx 9198 6 infections infection NNS cord-010092-uftc8inx 9198 7 ( ( -LRB- cord-010092-uftc8inx 9198 8 27.44 27.44 CD cord-010092-uftc8inx 9198 9 % % NN cord-010092-uftc8inx 9198 10 ) ) -RRB- cord-010092-uftc8inx 9198 11 , , , cord-010092-uftc8inx 9198 12 multiple multiple JJ cord-010092-uftc8inx 9198 13 transfusions transfusion NNS cord-010092-uftc8inx 9198 14 ( ( -LRB- cord-010092-uftc8inx 9198 15 17.41 17.41 CD cord-010092-uftc8inx 9198 16 % % NN cord-010092-uftc8inx 9198 17 ) ) -RRB- cord-010092-uftc8inx 9198 18 , , , cord-010092-uftc8inx 9198 19 trauma trauma NN cord-010092-uftc8inx 9198 20 ( ( -LRB- cord-010092-uftc8inx 9198 21 11.23 11.23 CD cord-010092-uftc8inx 9198 22 % % NN cord-010092-uftc8inx 9198 23 ) ) -RRB- cord-010092-uftc8inx 9198 24 , , , cord-010092-uftc8inx 9198 25 Evan Evan NNP cord-010092-uftc8inx 9198 26 's 's POS cord-010092-uftc8inx 9198 27 syndrome syndrome NN cord-010092-uftc8inx 9198 28 ( ( -LRB- cord-010092-uftc8inx 9198 29 4.15 4.15 CD cord-010092-uftc8inx 9198 30 % % NN cord-010092-uftc8inx 9198 31 ) ) -RRB- cord-010092-uftc8inx 9198 32 , , , cord-010092-uftc8inx 9198 33 Rh Rh NNP cord-010092-uftc8inx 9198 34 Negative negative JJ cord-010092-uftc8inx 9198 35 mother mother NN cord-010092-uftc8inx 9198 36 ( ( -LRB- cord-010092-uftc8inx 9198 37 3.57 3.57 CD cord-010092-uftc8inx 9198 38 % % NN cord-010092-uftc8inx 9198 39 ) ) -RRB- cord-010092-uftc8inx 9198 40 , , , cord-010092-uftc8inx 9198 41 SCA SCA NNP cord-010092-uftc8inx 9198 42 ( ( -LRB- cord-010092-uftc8inx 9198 43 2.99 2.99 CD cord-010092-uftc8inx 9198 44 % % NN cord-010092-uftc8inx 9198 45 ) ) -RRB- cord-010092-uftc8inx 9198 46 & & CC cord-010092-uftc8inx 9198 47 incompatibility incompatibility NN cord-010092-uftc8inx 9198 48 due due IN cord-010092-uftc8inx 9198 49 to to IN cord-010092-uftc8inx 9198 50 DAT DAT NNP cord-010092-uftc8inx 9198 51 positive positive JJ cord-010092-uftc8inx 9198 52 Packed packed JJ cord-010092-uftc8inx 9198 53 Red Red NNP cord-010092-uftc8inx 9198 54 Cells cell NNS cord-010092-uftc8inx 9199 1 ( ( -LRB- cord-010092-uftc8inx 9199 2 0.34%).The 0.34%).the CD cord-010092-uftc8inx 9199 3 most most RBS cord-010092-uftc8inx 9199 4 common common JJ cord-010092-uftc8inx 9199 5 antibody antibody NN cord-010092-uftc8inx 9199 6 found find VBD cord-010092-uftc8inx 9199 7 were be VBD cord-010092-uftc8inx 9199 8 anti-'c anti-'c NNP cord-010092-uftc8inx 9199 9 ' ' NNP cord-010092-uftc8inx 9199 10 , , , cord-010092-uftc8inx 9199 11 anti- anti- NNP cord-010092-uftc8inx 9199 12 's 's POS cord-010092-uftc8inx 9199 13 ' ' '' cord-010092-uftc8inx 9199 14 & & CC cord-010092-uftc8inx 9199 15 anti-'M anti-'M NNP cord-010092-uftc8inx 9199 16 ' ' '' cord-010092-uftc8inx 9199 17 . . . cord-010092-uftc8inx 9200 1 Summary Summary NNP cord-010092-uftc8inx 9200 2 / / SYM cord-010092-uftc8inx 9200 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 9200 4 : : : cord-010092-uftc8inx 9201 1 The the DT cord-010092-uftc8inx 9201 2 RCA RCA NNP cord-010092-uftc8inx 9201 3 protocol protocol NN cord-010092-uftc8inx 9201 4 involves involve VBZ cord-010092-uftc8inx 9201 5 a a DT cord-010092-uftc8inx 9201 6 thorough thorough JJ cord-010092-uftc8inx 9201 7 evaluation evaluation NN cord-010092-uftc8inx 9201 8 of of IN cord-010092-uftc8inx 9201 9 the the DT cord-010092-uftc8inx 9201 10 patient patient NN cord-010092-uftc8inx 9201 11 's 's POS cord-010092-uftc8inx 9201 12 clinical clinical JJ cord-010092-uftc8inx 9201 13 condition condition NN cord-010092-uftc8inx 9201 14 and and CC cord-010092-uftc8inx 9201 15 underlying underlying JJ cord-010092-uftc8inx 9201 16 pathology pathology NN cord-010092-uftc8inx 9201 17 to to TO cord-010092-uftc8inx 9201 18 identify identify VB cord-010092-uftc8inx 9201 19 the the DT cord-010092-uftc8inx 9201 20 cause cause NN cord-010092-uftc8inx 9201 21 . . . cord-010092-uftc8inx 9202 1 A a DT cord-010092-uftc8inx 9202 2 logical logical JJ cord-010092-uftc8inx 9202 3 stepwise stepwise JJ cord-010092-uftc8inx 9202 4 approach approach NN cord-010092-uftc8inx 9202 5 will will MD cord-010092-uftc8inx 9202 6 enable enable VB cord-010092-uftc8inx 9202 7 provision provision NN cord-010092-uftc8inx 9202 8 of of IN cord-010092-uftc8inx 9202 9 safe safe JJ cord-010092-uftc8inx 9202 10 transfusion transfusion NN cord-010092-uftc8inx 9202 11 to to IN cord-010092-uftc8inx 9202 12 the the DT cord-010092-uftc8inx 9202 13 patient patient NN cord-010092-uftc8inx 9202 14 . . . cord-010092-uftc8inx 9203 1 Background background NN cord-010092-uftc8inx 9203 2 : : : cord-010092-uftc8inx 9204 1 Antibodies antibody NNS cord-010092-uftc8inx 9204 2 to to IN cord-010092-uftc8inx 9204 3 high high JJ cord-010092-uftc8inx 9204 4 - - HYPH cord-010092-uftc8inx 9204 5 frequency frequency NN cord-010092-uftc8inx 9204 6 antigens antigen NNS cord-010092-uftc8inx 9204 7 ( ( -LRB- cord-010092-uftc8inx 9204 8 HFAs HFAs NNP cord-010092-uftc8inx 9204 9 ) ) -RRB- cord-010092-uftc8inx 9204 10 are be VBP cord-010092-uftc8inx 9204 11 a a DT cord-010092-uftc8inx 9204 12 transfusion transfusion NN cord-010092-uftc8inx 9204 13 hazard hazard NN cord-010092-uftc8inx 9204 14 , , , cord-010092-uftc8inx 9204 15 as as IN cord-010092-uftc8inx 9204 16 compatible compatible JJ cord-010092-uftc8inx 9204 17 blood blood NN cord-010092-uftc8inx 9204 18 is be VBZ cord-010092-uftc8inx 9204 19 often often RB cord-010092-uftc8inx 9204 20 very very RB cord-010092-uftc8inx 9204 21 difficult difficult JJ cord-010092-uftc8inx 9204 22 to to TO cord-010092-uftc8inx 9204 23 obtain obtain VB cord-010092-uftc8inx 9204 24 . . . cord-010092-uftc8inx 9205 1 Other other JJ cord-010092-uftc8inx 9205 2 clinically clinically RB cord-010092-uftc8inx 9205 3 significant significant JJ cord-010092-uftc8inx 9205 4 alloantibodies alloantibody NNS cord-010092-uftc8inx 9205 5 represent represent VBP cord-010092-uftc8inx 9205 6 an an DT cord-010092-uftc8inx 9205 7 additional additional JJ cord-010092-uftc8inx 9205 8 transfusion transfusion NN cord-010092-uftc8inx 9205 9 risk risk NN cord-010092-uftc8inx 9205 10 . . . cord-010092-uftc8inx 9206 1 In in IN cord-010092-uftc8inx 9206 2 patients patient NNS cord-010092-uftc8inx 9206 3 treated treat VBN cord-010092-uftc8inx 9206 4 with with IN cord-010092-uftc8inx 9206 5 allogeneic allogeneic NN cord-010092-uftc8inx 9206 6 bone bone NN cord-010092-uftc8inx 9206 7 marrow marrow NN cord-010092-uftc8inx 9206 8 transplantation transplantation NN cord-010092-uftc8inx 9206 9 ( ( -LRB- cord-010092-uftc8inx 9206 10 BMT BMT NNP cord-010092-uftc8inx 9206 11 ) ) -RRB- cord-010092-uftc8inx 9206 12 recipient recipient NN cord-010092-uftc8inx 9206 13 red red JJ cord-010092-uftc8inx 9206 14 cell cell NN cord-010092-uftc8inx 9206 15 alloantibodies alloantibody NNS cord-010092-uftc8inx 9206 16 may may MD cord-010092-uftc8inx 9206 17 cause cause VB cord-010092-uftc8inx 9206 18 acute acute JJ cord-010092-uftc8inx 9206 19 or or CC cord-010092-uftc8inx 9206 20 delayed delayed JJ cord-010092-uftc8inx 9206 21 haemolysis haemolysis NN cord-010092-uftc8inx 9206 22 of of IN cord-010092-uftc8inx 9206 23 donor donor NN cord-010092-uftc8inx 9206 24 red red JJ cord-010092-uftc8inx 9206 25 blood blood NN cord-010092-uftc8inx 9206 26 cells cell NNS cord-010092-uftc8inx 9206 27 ( ( -LRB- cord-010092-uftc8inx 9206 28 RBC RBC NNP cord-010092-uftc8inx 9206 29 ) ) -RRB- cord-010092-uftc8inx 9206 30 and and CC cord-010092-uftc8inx 9206 31 contribute contribute VB cord-010092-uftc8inx 9206 32 to to IN cord-010092-uftc8inx 9206 33 morbidity morbidity NN cord-010092-uftc8inx 9206 34 and and CC cord-010092-uftc8inx 9206 35 mortality mortality NN cord-010092-uftc8inx 9206 36 . . . cord-010092-uftc8inx 9207 1 Aims aim VBZ cord-010092-uftc8inx 9207 2 : : : cord-010092-uftc8inx 9208 1 The the DT cord-010092-uftc8inx 9208 2 aim aim NN cord-010092-uftc8inx 9208 3 is be VBZ cord-010092-uftc8inx 9208 4 to to TO cord-010092-uftc8inx 9208 5 present present VB cord-010092-uftc8inx 9208 6 the the DT cord-010092-uftc8inx 9208 7 case case NN cord-010092-uftc8inx 9208 8 of of IN cord-010092-uftc8inx 9208 9 a a DT cord-010092-uftc8inx 9208 10 patient patient NN cord-010092-uftc8inx 9208 11 with with IN cord-010092-uftc8inx 9208 12 Myelodysplastic Myelodysplastic NNP cord-010092-uftc8inx 9208 13 Syndrome Syndrome NNP cord-010092-uftc8inx 9208 14 ( ( -LRB- cord-010092-uftc8inx 9208 15 MDS MDS NNP cord-010092-uftc8inx 9208 16 ) ) -RRB- cord-010092-uftc8inx 9208 17 , , , cord-010092-uftc8inx 9208 18 multiple multiple JJ cord-010092-uftc8inx 9208 19 " " `` cord-010092-uftc8inx 9208 20 common common JJ cord-010092-uftc8inx 9208 21 " " '' cord-010092-uftc8inx 9208 22 alloantibodies alloantibody NNS cord-010092-uftc8inx 9208 23 and and CC cord-010092-uftc8inx 9208 24 an an DT cord-010092-uftc8inx 9208 25 additional additional JJ cord-010092-uftc8inx 9208 26 alloantibody alloantibody NN cord-010092-uftc8inx 9208 27 to to IN cord-010092-uftc8inx 9208 28 a a DT cord-010092-uftc8inx 9208 29 highfrequency highfrequency NN cord-010092-uftc8inx 9208 30 antigen antigen NN cord-010092-uftc8inx 9208 31 , , , cord-010092-uftc8inx 9208 32 treated treat VBN cord-010092-uftc8inx 9208 33 with with IN cord-010092-uftc8inx 9208 34 allogeneic allogeneic NN cord-010092-uftc8inx 9208 35 BMT BMT NNP cord-010092-uftc8inx 9208 36 . . . cord-010092-uftc8inx 9209 1 Methods method NNS cord-010092-uftc8inx 9209 2 : : : cord-010092-uftc8inx 9210 1 A a DT cord-010092-uftc8inx 9210 2 forty forty CD cord-010092-uftc8inx 9210 3 - - HYPH cord-010092-uftc8inx 9210 4 one one CD cord-010092-uftc8inx 9210 5 - - HYPH cord-010092-uftc8inx 9210 6 year year NN cord-010092-uftc8inx 9210 7 - - HYPH cord-010092-uftc8inx 9210 8 old old JJ cord-010092-uftc8inx 9210 9 Caucasian caucasian JJ cord-010092-uftc8inx 9210 10 patient patient NN cord-010092-uftc8inx 9210 11 with with IN cord-010092-uftc8inx 9210 12 MDS MDS NNP cord-010092-uftc8inx 9210 13 ( ( -LRB- cord-010092-uftc8inx 9210 14 RAEB-1 RAEB-1 NNP cord-010092-uftc8inx 9210 15 ) ) -RRB- cord-010092-uftc8inx 9210 16 was be VBD cord-010092-uftc8inx 9210 17 admitted admit VBN cord-010092-uftc8inx 9210 18 to to IN cord-010092-uftc8inx 9210 19 our -PRON- PRP$ cord-010092-uftc8inx 9210 20 hospital hospital NN cord-010092-uftc8inx 9210 21 in in IN cord-010092-uftc8inx 9210 22 January January NNP cord-010092-uftc8inx 9210 23 2017 2017 CD cord-010092-uftc8inx 9210 24 for for IN cord-010092-uftc8inx 9210 25 unrelated unrelated JJ cord-010092-uftc8inx 9210 26 allogeneic allogeneic IN cord-010092-uftc8inx 9210 27 BMT BMT NNP cord-010092-uftc8inx 9210 28 . . . cord-010092-uftc8inx 9211 1 She -PRON- PRP cord-010092-uftc8inx 9211 2 previously previously RB cord-010092-uftc8inx 9211 3 received receive VBD cord-010092-uftc8inx 9211 4 myeloablative myeloablative JJ cord-010092-uftc8inx 9211 5 conditioning conditioning NN cord-010092-uftc8inx 9211 6 therapy therapy NN cord-010092-uftc8inx 9211 7 according accord VBG cord-010092-uftc8inx 9211 8 to to IN cord-010092-uftc8inx 9211 9 the the DT cord-010092-uftc8inx 9211 10 Flu Flu NNP cord-010092-uftc8inx 9211 11 / / SYM cord-010092-uftc8inx 9211 12 Bu4 bu4 NN cord-010092-uftc8inx 9211 13 / / SYM cord-010092-uftc8inx 9211 14 ATG ATG NNP cord-010092-uftc8inx 9211 15 protocol protocol NN cord-010092-uftc8inx 9211 16 ( ( -LRB- cord-010092-uftc8inx 9211 17 5 5 CD cord-010092-uftc8inx 9211 18 days day NNS cord-010092-uftc8inx 9211 19 of of IN cord-010092-uftc8inx 9211 20 250 250 CD cord-010092-uftc8inx 9211 21 mg mg NN cord-010092-uftc8inx 9212 1 iv iv LS cord-010092-uftc8inx 9212 2 . . . cord-010092-uftc8inx 9213 1 Fludarabine Fludarabine NNP cord-010092-uftc8inx 9213 2 , , , cord-010092-uftc8inx 9213 3 4 4 CD cord-010092-uftc8inx 9213 4 days day NNS cord-010092-uftc8inx 9213 5 of of IN cord-010092-uftc8inx 9213 6 Busulfan Busulfan NNP cord-010092-uftc8inx 9214 1 792 792 CD cord-010092-uftc8inx 9214 2 mg mg NNP cord-010092-uftc8inx 9214 3 iv iv CD cord-010092-uftc8inx 9214 4 , , , cord-010092-uftc8inx 9215 1 2 2 CD cord-010092-uftc8inx 9215 2 days day NNS cord-010092-uftc8inx 9215 3 of of IN cord-010092-uftc8inx 9215 4 300 300 CD cord-010092-uftc8inx 9215 5 mg mg NN cord-010092-uftc8inx 9215 6 iv iv CD cord-010092-uftc8inx 9215 7 . . . cord-010092-uftc8inx 9216 1 Antithymocyte Antithymocyte NNP cord-010092-uftc8inx 9216 2 Globulin Globulin NNP cord-010092-uftc8inx 9216 3 ) ) -RRB- cord-010092-uftc8inx 9216 4 . . . cord-010092-uftc8inx 9217 1 The the DT cord-010092-uftc8inx 9217 2 indirect indirect JJ cord-010092-uftc8inx 9217 3 antiglobulin antiglobulin NN cord-010092-uftc8inx 9217 4 test test NN cord-010092-uftc8inx 9217 5 ( ( -LRB- cord-010092-uftc8inx 9217 6 IAT IAT NNP cord-010092-uftc8inx 9217 7 ) ) -RRB- cord-010092-uftc8inx 9217 8 , , , cord-010092-uftc8inx 9217 9 done do VBN cord-010092-uftc8inx 9217 10 in in IN cord-010092-uftc8inx 9217 11 August August NNP cord-010092-uftc8inx 9217 12 and and CC cord-010092-uftc8inx 9217 13 December December NNP cord-010092-uftc8inx 9217 14 of of IN cord-010092-uftc8inx 9217 15 2016 2016 CD cord-010092-uftc8inx 9217 16 , , , cord-010092-uftc8inx 9217 17 was be VBD cord-010092-uftc8inx 9217 18 negative negative JJ cord-010092-uftc8inx 9217 19 . . . cord-010092-uftc8inx 9218 1 According accord VBG cord-010092-uftc8inx 9218 2 to to IN cord-010092-uftc8inx 9218 3 anamnestic anamnestic JJ cord-010092-uftc8inx 9218 4 data datum NNS cord-010092-uftc8inx 9218 5 , , , cord-010092-uftc8inx 9218 6 the the DT cord-010092-uftc8inx 9218 7 patient patient NN cord-010092-uftc8inx 9218 8 had have VBD cord-010092-uftc8inx 9218 9 two two CD cord-010092-uftc8inx 9218 10 pregnancies pregnancy NNS cord-010092-uftc8inx 9218 11 . . . cord-010092-uftc8inx 9219 1 She -PRON- PRP cord-010092-uftc8inx 9219 2 received receive VBD cord-010092-uftc8inx 9219 3 red red JJ cord-010092-uftc8inx 9219 4 cell cell NN cord-010092-uftc8inx 9219 5 transfusions transfusion NNS cord-010092-uftc8inx 9219 6 during during IN cord-010092-uftc8inx 9219 7 childbirth childbirth NN cord-010092-uftc8inx 9219 8 and and CC cord-010092-uftc8inx 9219 9 platelets platelet NNS cord-010092-uftc8inx 9219 10 in in IN cord-010092-uftc8inx 9219 11 December December NNP cord-010092-uftc8inx 9219 12 2016 2016 CD cord-010092-uftc8inx 9219 13 . . . cord-010092-uftc8inx 9220 1 Results result NNS cord-010092-uftc8inx 9220 2 : : : cord-010092-uftc8inx 9221 1 The the DT cord-010092-uftc8inx 9221 2 patient patient NN cord-010092-uftc8inx 9221 3 's 's POS cord-010092-uftc8inx 9221 4 blood blood NN cord-010092-uftc8inx 9221 5 group group NN cord-010092-uftc8inx 9221 6 was be VBD cord-010092-uftc8inx 9221 7 O o UH cord-010092-uftc8inx 9221 8 RhD rhd NN cord-010092-uftc8inx 9221 9 positive positive JJ cord-010092-uftc8inx 9221 10 , , , cord-010092-uftc8inx 9221 11 IAT IAT NNP cord-010092-uftc8inx 9221 12 positive positive JJ cord-010092-uftc8inx 9221 13 . . . cord-010092-uftc8inx 9222 1 The the DT cord-010092-uftc8inx 9222 2 donor donor NN cord-010092-uftc8inx 9222 3 blood blood NN cord-010092-uftc8inx 9222 4 group group NN cord-010092-uftc8inx 9222 5 was be VBD cord-010092-uftc8inx 9222 6 A a DT cord-010092-uftc8inx 9222 7 RhD rhd NN cord-010092-uftc8inx 9222 8 positive positive JJ cord-010092-uftc8inx 9222 9 , , , cord-010092-uftc8inx 9222 10 IAT IAT NNP cord-010092-uftc8inx 9222 11 negative negative JJ cord-010092-uftc8inx 9222 12 . . . cord-010092-uftc8inx 9223 1 Phenotype phenotype NN cord-010092-uftc8inx 9223 2 of of IN cord-010092-uftc8inx 9223 3 the the DT cord-010092-uftc8inx 9223 4 recipient recipient NN cord-010092-uftc8inx 9223 5 's 's POS cord-010092-uftc8inx 9223 6 RBCs rbc NNS cord-010092-uftc8inx 9223 7 , , , cord-010092-uftc8inx 9223 8 as as RB cord-010092-uftc8inx 9223 9 well well RB cord-010092-uftc8inx 9223 10 as as IN cord-010092-uftc8inx 9223 11 the the DT cord-010092-uftc8inx 9223 12 donor donor NN cord-010092-uftc8inx 9223 13 RBCs rbc NNS cord-010092-uftc8inx 9223 14 , , , cord-010092-uftc8inx 9223 15 was be VBD cord-010092-uftc8inx 9223 16 also also RB cord-010092-uftc8inx 9223 17 determined determine VBN cord-010092-uftc8inx 9223 18 . . . cord-010092-uftc8inx 9224 1 Anti anti JJ cord-010092-uftc8inx 9224 2 - - NN cord-010092-uftc8inx 9224 3 E E NNS cord-010092-uftc8inx 9224 4 and and CC cord-010092-uftc8inx 9224 5 -C -C NNS cord-010092-uftc8inx 9224 6 w w NN cord-010092-uftc8inx 9224 7 were be VBD cord-010092-uftc8inx 9224 8 found find VBN cord-010092-uftc8inx 9224 9 in in IN cord-010092-uftc8inx 9224 10 the the DT cord-010092-uftc8inx 9224 11 patient patient NN cord-010092-uftc8inx 9224 12 's 's POS cord-010092-uftc8inx 9224 13 plasma plasma NN cord-010092-uftc8inx 9224 14 , , , cord-010092-uftc8inx 9224 15 but but CC cord-010092-uftc8inx 9224 16 an an DT cord-010092-uftc8inx 9224 17 additional additional JJ cord-010092-uftc8inx 9224 18 alloantibody alloantibody NN cord-010092-uftc8inx 9224 19 was be VBD cord-010092-uftc8inx 9224 20 suspected suspect VBN cord-010092-uftc8inx 9224 21 . . . cord-010092-uftc8inx 9225 1 The the DT cord-010092-uftc8inx 9225 2 autocontrol autocontrol NN cord-010092-uftc8inx 9225 3 was be VBD cord-010092-uftc8inx 9225 4 negative negative JJ cord-010092-uftc8inx 9225 5 . . . cord-010092-uftc8inx 9226 1 Column column NN cord-010092-uftc8inx 9226 2 agglutination agglutination NN cord-010092-uftc8inx 9226 3 technology technology NN cord-010092-uftc8inx 9226 4 ( ( -LRB- cord-010092-uftc8inx 9226 5 CAT cat NN cord-010092-uftc8inx 9226 6 ) ) -RRB- cord-010092-uftc8inx 9226 7 and and CC cord-010092-uftc8inx 9226 8 tube tube NN cord-010092-uftc8inx 9226 9 technology technology NN cord-010092-uftc8inx 9226 10 were be VBD cord-010092-uftc8inx 9226 11 used use VBN cord-010092-uftc8inx 9226 12 to to TO cord-010092-uftc8inx 9226 13 identify identify VB cord-010092-uftc8inx 9226 14 RBC RBC NNP cord-010092-uftc8inx 9226 15 antibodies antibody NNS cord-010092-uftc8inx 9226 16 . . . cord-010092-uftc8inx 9227 1 Plasma plasma NN cord-010092-uftc8inx 9227 2 was be VBD cord-010092-uftc8inx 9227 3 tested test VBN cord-010092-uftc8inx 9227 4 with with IN cord-010092-uftc8inx 9227 5 pheno pheno NN cord-010092-uftc8inx 9227 6 - - HYPH cord-010092-uftc8inx 9227 7 matched match VBN cord-010092-uftc8inx 9227 8 RBCs rbc NNS cord-010092-uftc8inx 9227 9 , , , cord-010092-uftc8inx 9227 10 papain papain NN cord-010092-uftc8inx 9227 11 - - : cord-010092-uftc8inx 9227 12 and and CC cord-010092-uftc8inx 9227 13 0.2 0.2 CD cord-010092-uftc8inx 9227 14 M M NNP cord-010092-uftc8inx 9227 15 dithiothreitol dithiothreitol NN cord-010092-uftc8inx 9227 16 - - HYPH cord-010092-uftc8inx 9227 17 treated treat VBN cord-010092-uftc8inx 9227 18 RBCs rbc NNS cord-010092-uftc8inx 9227 19 , , , cord-010092-uftc8inx 9227 20 as as RB cord-010092-uftc8inx 9227 21 well well RB cord-010092-uftc8inx 9227 22 as as IN cord-010092-uftc8inx 9227 23 cord cord NN cord-010092-uftc8inx 9227 24 and and CC cord-010092-uftc8inx 9227 25 autologous autologous JJ cord-010092-uftc8inx 9227 26 RBCs rbc NNS cord-010092-uftc8inx 9227 27 . . . cord-010092-uftc8inx 9228 1 Adsorption adsorption NN cord-010092-uftc8inx 9228 2 and and CC cord-010092-uftc8inx 9228 3 elution elution NN cord-010092-uftc8inx 9228 4 tests test NNS cord-010092-uftc8inx 9228 5 were be VBD cord-010092-uftc8inx 9228 6 done do VBN cord-010092-uftc8inx 9228 7 , , , cord-010092-uftc8inx 9228 8 excluding exclude VBG cord-010092-uftc8inx 9228 9 other other JJ cord-010092-uftc8inx 9228 10 " " `` cord-010092-uftc8inx 9228 11 usual usual JJ cord-010092-uftc8inx 9228 12 " " '' cord-010092-uftc8inx 9228 13 clinically clinically RB cord-010092-uftc8inx 9228 14 significant significant JJ cord-010092-uftc8inx 9228 15 alloantibodies alloantibody NNS cord-010092-uftc8inx 9228 16 , , , cord-010092-uftc8inx 9228 17 and and CC cord-010092-uftc8inx 9228 18 the the DT cord-010092-uftc8inx 9228 19 patient patient NN cord-010092-uftc8inx 9228 20 received receive VBD cord-010092-uftc8inx 9228 21 three three CD cord-010092-uftc8inx 9228 22 incompatible incompatible JJ cord-010092-uftc8inx 9228 23 ( ( -LRB- cord-010092-uftc8inx 9228 24 XM XM NNP cord-010092-uftc8inx 9228 25 in in IN cord-010092-uftc8inx 9228 26 IAT IAT NNP cord-010092-uftc8inx 9228 27 , , , cord-010092-uftc8inx 9228 28 CAT CAT NNP cord-010092-uftc8inx 9228 29 ) ) -RRB- cord-010092-uftc8inx 9228 30 Yt(a+ Yt(a+ NNP cord-010092-uftc8inx 9228 31 ) ) -RRB- cord-010092-uftc8inx 9228 32 , , , cord-010092-uftc8inx 9228 33 E- E- NNP cord-010092-uftc8inx 9228 34 , , , cord-010092-uftc8inx 9228 35 C C NNP cord-010092-uftc8inx 9228 36 w w NNP cord-010092-uftc8inx 9228 37 - - : cord-010092-uftc8inx 9228 38 , , , cord-010092-uftc8inx 9228 39 K K NNP cord-010092-uftc8inx 9228 40 - - HYPH cord-010092-uftc8inx 9228 41 red red JJ cord-010092-uftc8inx 9228 42 cell cell NN cord-010092-uftc8inx 9228 43 units unit NNS cord-010092-uftc8inx 9228 44 . . . cord-010092-uftc8inx 9229 1 The the DT cord-010092-uftc8inx 9229 2 sample sample NN cord-010092-uftc8inx 9229 3 was be VBD cord-010092-uftc8inx 9229 4 urgently urgently RB cord-010092-uftc8inx 9229 5 sent send VBN cord-010092-uftc8inx 9229 6 for for IN cord-010092-uftc8inx 9229 7 an an DT cord-010092-uftc8inx 9229 8 antibody antibody NN cord-010092-uftc8inx 9229 9 investigation investigation NN cord-010092-uftc8inx 9229 10 at at IN cord-010092-uftc8inx 9229 11 the the DT cord-010092-uftc8inx 9229 12 International International NNP cord-010092-uftc8inx 9229 13 Blood Blood NNP cord-010092-uftc8inx 9229 14 Group Group NNP cord-010092-uftc8inx 9229 15 Reference Reference NNP cord-010092-uftc8inx 9229 16 Laboratory Laboratory NNP cord-010092-uftc8inx 9229 17 ( ( -LRB- cord-010092-uftc8inx 9229 18 Bristol Bristol NNP cord-010092-uftc8inx 9229 19 , , , cord-010092-uftc8inx 9229 20 UK UK NNP cord-010092-uftc8inx 9229 21 ) ) -RRB- cord-010092-uftc8inx 9229 22 . . . cord-010092-uftc8inx 9230 1 In in IN cord-010092-uftc8inx 9230 2 the the DT cord-010092-uftc8inx 9230 3 reference reference NN cord-010092-uftc8inx 9230 4 laboratory laboratory NN cord-010092-uftc8inx 9230 5 , , , cord-010092-uftc8inx 9230 6 anti anti JJ cord-010092-uftc8inx 9230 7 - - JJ cord-010092-uftc8inx 9230 8 E e JJ cord-010092-uftc8inx 9230 9 , , , cord-010092-uftc8inx 9230 10 -C -C : cord-010092-uftc8inx 9230 11 w w NN cord-010092-uftc8inx 9230 12 and and CC cord-010092-uftc8inx 9230 13 an an DT cord-010092-uftc8inx 9230 14 alloantibody alloantibody NN cord-010092-uftc8inx 9230 15 to to IN cord-010092-uftc8inx 9230 16 a a DT cord-010092-uftc8inx 9230 17 high high JJ cord-010092-uftc8inx 9230 18 - - HYPH cord-010092-uftc8inx 9230 19 frequency frequency NN cord-010092-uftc8inx 9230 20 antigen antigen NN cord-010092-uftc8inx 9230 21 were be VBD cord-010092-uftc8inx 9230 22 confirmed confirm VBN cord-010092-uftc8inx 9230 23 , , , cord-010092-uftc8inx 9230 24 whose whose WP$ cord-010092-uftc8inx 9230 25 specificity specificity NN cord-010092-uftc8inx 9230 26 was be VBD cord-010092-uftc8inx 9230 27 determined determine VBN cord-010092-uftc8inx 9230 28 to to TO cord-010092-uftc8inx 9230 29 be be VB cord-010092-uftc8inx 9230 30 anti anti JJ cord-010092-uftc8inx 9230 31 - - JJ cord-010092-uftc8inx 9230 32 Yt Yt NNP cord-010092-uftc8inx 9230 33 a a NN cord-010092-uftc8inx 9230 34 . . . cord-010092-uftc8inx 9231 1 Anti Anti NNP cord-010092-uftc8inx 9231 2 - - NNP cord-010092-uftc8inx 9231 3 Jk Jk NNP cord-010092-uftc8inx 9231 4 b b NNP cord-010092-uftc8inx 9231 5 was be VBD cord-010092-uftc8inx 9231 6 also also RB cord-010092-uftc8inx 9231 7 suspected suspect VBN cord-010092-uftc8inx 9231 8 and and CC cord-010092-uftc8inx 9231 9 later later RB cord-010092-uftc8inx 9231 10 confirmed confirm VBN cord-010092-uftc8inx 9231 11 . . . cord-010092-uftc8inx 9232 1 Before before IN cord-010092-uftc8inx 9232 2 the the DT cord-010092-uftc8inx 9232 3 patient patient NN cord-010092-uftc8inx 9232 4 was be VBD cord-010092-uftc8inx 9232 5 discharged discharge VBN cord-010092-uftc8inx 9232 6 from from IN cord-010092-uftc8inx 9232 7 the the DT cord-010092-uftc8inx 9232 8 hospital hospital NN cord-010092-uftc8inx 9232 9 , , , cord-010092-uftc8inx 9232 10 she -PRON- PRP cord-010092-uftc8inx 9232 11 received receive VBD cord-010092-uftc8inx 9232 12 eight eight CD cord-010092-uftc8inx 9232 13 more more JJR cord-010092-uftc8inx 9232 14 red red JJ cord-010092-uftc8inx 9232 15 cell cell NN cord-010092-uftc8inx 9232 16 units unit NNS cord-010092-uftc8inx 9232 17 ( ( -LRB- cord-010092-uftc8inx 9232 18 Yt(a+ Yt(a+ NNP cord-010092-uftc8inx 9232 19 ) ) -RRB- cord-010092-uftc8inx 9232 20 , , , cord-010092-uftc8inx 9232 21 E- E- NNP cord-010092-uftc8inx 9232 22 , , , cord-010092-uftc8inx 9232 23 C C NNP cord-010092-uftc8inx 9232 24 w w NNP cord-010092-uftc8inx 9232 25 - - : cord-010092-uftc8inx 9232 26 , , , cord-010092-uftc8inx 9232 27 Jk(b- Jk(b- NNP cord-010092-uftc8inx 9232 28 ) ) -RRB- cord-010092-uftc8inx 9232 29 ) ) -RRB- cord-010092-uftc8inx 9232 30 , , , cord-010092-uftc8inx 9232 31 during during IN cord-010092-uftc8inx 9232 32 which which WDT cord-010092-uftc8inx 9232 33 she -PRON- PRP cord-010092-uftc8inx 9232 34 was be VBD cord-010092-uftc8inx 9232 35 serologically serologically RB cord-010092-uftc8inx 9232 36 closely closely RB cord-010092-uftc8inx 9232 37 monitored monitor VBN cord-010092-uftc8inx 9232 38 . . . cord-010092-uftc8inx 9233 1 Summary Summary NNP cord-010092-uftc8inx 9233 2 / / SYM cord-010092-uftc8inx 9233 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 9233 4 : : : cord-010092-uftc8inx 9234 1 The the DT cord-010092-uftc8inx 9234 2 results result NNS cord-010092-uftc8inx 9234 3 of of IN cord-010092-uftc8inx 9234 4 the the DT cord-010092-uftc8inx 9234 5 antibody antibody NN cord-010092-uftc8inx 9234 6 investigation investigation NN cord-010092-uftc8inx 9234 7 in in IN cord-010092-uftc8inx 9234 8 this this DT cord-010092-uftc8inx 9234 9 case case NN cord-010092-uftc8inx 9234 10 study study NN cord-010092-uftc8inx 9234 11 indicate indicate VBP cord-010092-uftc8inx 9234 12 the the DT cord-010092-uftc8inx 9234 13 presence presence NN cord-010092-uftc8inx 9234 14 of of IN cord-010092-uftc8inx 9234 15 multiple multiple JJ cord-010092-uftc8inx 9234 16 alloantibodies alloantibody NNS cord-010092-uftc8inx 9234 17 in in IN cord-010092-uftc8inx 9234 18 a a DT cord-010092-uftc8inx 9234 19 patient patient NN cord-010092-uftc8inx 9234 20 who who WP cord-010092-uftc8inx 9234 21 has have VBZ cord-010092-uftc8inx 9234 22 previously previously RB cord-010092-uftc8inx 9234 23 received receive VBN cord-010092-uftc8inx 9234 24 immunosuppressive immunosuppressive JJ cord-010092-uftc8inx 9234 25 myeloablative myeloablative JJ cord-010092-uftc8inx 9234 26 conditioning conditioning NN cord-010092-uftc8inx 9234 27 therapy therapy NN cord-010092-uftc8inx 9234 28 . . . cord-010092-uftc8inx 9235 1 In in IN cord-010092-uftc8inx 9235 2 addition addition NN cord-010092-uftc8inx 9235 3 to to IN cord-010092-uftc8inx 9235 4 the the DT cord-010092-uftc8inx 9235 5 " " `` cord-010092-uftc8inx 9235 6 common common JJ cord-010092-uftc8inx 9235 7 " " '' cord-010092-uftc8inx 9235 8 alloantibodies alloantibody NNS cord-010092-uftc8inx 9235 9 ( ( -LRB- cord-010092-uftc8inx 9235 10 anti anti JJ cord-010092-uftc8inx 9235 11 - - JJ cord-010092-uftc8inx 9235 12 E e JJ cord-010092-uftc8inx 9235 13 , , , cord-010092-uftc8inx 9235 14 -C -C : cord-010092-uftc8inx 9235 15 w w NN cord-010092-uftc8inx 9235 16 , , , cord-010092-uftc8inx 9235 17 -Jk -Jk : cord-010092-uftc8inx 9235 18 b b LS cord-010092-uftc8inx 9235 19 ) ) -RRB- cord-010092-uftc8inx 9235 20 , , , cord-010092-uftc8inx 9235 21 an an DT cord-010092-uftc8inx 9235 22 alloantibody alloantibody NN cord-010092-uftc8inx 9235 23 to to IN cord-010092-uftc8inx 9235 24 a a DT cord-010092-uftc8inx 9235 25 high high JJ cord-010092-uftc8inx 9235 26 - - HYPH cord-010092-uftc8inx 9235 27 frequency frequency NN cord-010092-uftc8inx 9235 28 antigen antigen NN cord-010092-uftc8inx 9235 29 ( ( -LRB- cord-010092-uftc8inx 9235 30 anti anti NNP cord-010092-uftc8inx 9235 31 - - JJ cord-010092-uftc8inx 9235 32 Yt Yt NNP cord-010092-uftc8inx 9235 33 a a DT cord-010092-uftc8inx 9235 34 ) ) -RRB- cord-010092-uftc8inx 9235 35 was be VBD cord-010092-uftc8inx 9235 36 detected detect VBN cord-010092-uftc8inx 9235 37 in in IN cord-010092-uftc8inx 9235 38 the the DT cord-010092-uftc8inx 9235 39 patient patient NN cord-010092-uftc8inx 9235 40 . . . cord-010092-uftc8inx 9236 1 This this DT cord-010092-uftc8inx 9236 2 patient patient NN cord-010092-uftc8inx 9236 3 was be VBD cord-010092-uftc8inx 9236 4 transfused transfuse VBN cord-010092-uftc8inx 9236 5 with with IN cord-010092-uftc8inx 9236 6 incompatible incompatible JJ cord-010092-uftc8inx 9236 7 red red JJ cord-010092-uftc8inx 9236 8 cell cell NN cord-010092-uftc8inx 9236 9 units unit NNS cord-010092-uftc8inx 9236 10 ( ( -LRB- cord-010092-uftc8inx 9236 11 Yt(a+ Yt(a+ NNP cord-010092-uftc8inx 9236 12 ) ) -RRB- cord-010092-uftc8inx 9236 13 ) ) -RRB- cord-010092-uftc8inx 9236 14 in in IN cord-010092-uftc8inx 9236 15 an an DT cord-010092-uftc8inx 9236 16 emergency emergency NN cord-010092-uftc8inx 9236 17 , , , cord-010092-uftc8inx 9236 18 with with IN cord-010092-uftc8inx 9236 19 no no DT cord-010092-uftc8inx 9236 20 ill ill JJ cord-010092-uftc8inx 9236 21 effects effect NNS cord-010092-uftc8inx 9236 22 . . . cord-010092-uftc8inx 9237 1 Although although IN cord-010092-uftc8inx 9237 2 anti anti JJ cord-010092-uftc8inx 9237 3 - - NNP cord-010092-uftc8inx 9237 4 Yt Yt NNP cord-010092-uftc8inx 9237 5 a a DT cord-010092-uftc8inx 9237 6 is be VBZ cord-010092-uftc8inx 9237 7 rarely rarely RB cord-010092-uftc8inx 9237 8 a a DT cord-010092-uftc8inx 9237 9 clinically clinically RB cord-010092-uftc8inx 9237 10 significant significant JJ cord-010092-uftc8inx 9237 11 antibody antibody NN cord-010092-uftc8inx 9237 12 , , , cord-010092-uftc8inx 9237 13 according accord VBG cord-010092-uftc8inx 9237 14 to to IN cord-010092-uftc8inx 9237 15 literature literature NN cord-010092-uftc8inx 9237 16 , , , cord-010092-uftc8inx 9237 17 it -PRON- PRP cord-010092-uftc8inx 9237 18 can can MD cord-010092-uftc8inx 9237 19 cause cause VB cord-010092-uftc8inx 9237 20 immediate immediate JJ cord-010092-uftc8inx 9237 21 haemolytic haemolytic JJ cord-010092-uftc8inx 9237 22 transfusion transfusion NN cord-010092-uftc8inx 9237 23 reaction reaction NN cord-010092-uftc8inx 9237 24 . . . cord-010092-uftc8inx 9238 1 Additional additional JJ cord-010092-uftc8inx 9238 2 risk risk NN cord-010092-uftc8inx 9238 3 were be VBD cord-010092-uftc8inx 9238 4 " " `` cord-010092-uftc8inx 9238 5 common common JJ cord-010092-uftc8inx 9238 6 " " '' cord-010092-uftc8inx 9238 7 clinically clinically RB cord-010092-uftc8inx 9238 8 significant significant JJ cord-010092-uftc8inx 9238 9 alloantibodies alloantibody NNS cord-010092-uftc8inx 9238 10 , , , cord-010092-uftc8inx 9238 11 especially especially RB cord-010092-uftc8inx 9238 12 anti anti JJ cord-010092-uftc8inx 9238 13 - - JJ cord-010092-uftc8inx 9238 14 Jk Jk NNP cord-010092-uftc8inx 9238 15 b b NNP cord-010092-uftc8inx 9238 16 , , , cord-010092-uftc8inx 9238 17 which which WDT cord-010092-uftc8inx 9238 18 was be VBD cord-010092-uftc8inx 9238 19 in in IN cord-010092-uftc8inx 9238 20 this this DT cord-010092-uftc8inx 9238 21 case case NN cord-010092-uftc8inx 9238 22 extremely extremely RB cord-010092-uftc8inx 9238 23 difficult difficult JJ cord-010092-uftc8inx 9238 24 to to TO cord-010092-uftc8inx 9238 25 detect detect VB cord-010092-uftc8inx 9238 26 and and CC cord-010092-uftc8inx 9238 27 had have VBD cord-010092-uftc8inx 9238 28 further further RB cord-010092-uftc8inx 9238 29 complicated complicate VBN cord-010092-uftc8inx 9238 30 the the DT cord-010092-uftc8inx 9238 31 selection selection NN cord-010092-uftc8inx 9238 32 of of IN cord-010092-uftc8inx 9238 33 blood blood NN cord-010092-uftc8inx 9238 34 . . . cord-010092-uftc8inx 9239 1 Background background NN cord-010092-uftc8inx 9239 2 : : : cord-010092-uftc8inx 9240 1 The the DT cord-010092-uftc8inx 9240 2 identification identification NN cord-010092-uftc8inx 9240 3 of of IN cord-010092-uftc8inx 9240 4 an an DT cord-010092-uftc8inx 9240 5 antibody antibody NN cord-010092-uftc8inx 9240 6 against against IN cord-010092-uftc8inx 9240 7 a a DT cord-010092-uftc8inx 9240 8 high high JJ cord-010092-uftc8inx 9240 9 - - HYPH cord-010092-uftc8inx 9240 10 incidence incidence NN cord-010092-uftc8inx 9240 11 antigen antigen NN cord-010092-uftc8inx 9240 12 always always RB cord-010092-uftc8inx 9240 13 introduces introduce VBZ cord-010092-uftc8inx 9240 14 a a DT cord-010092-uftc8inx 9240 15 challenge challenge NN cord-010092-uftc8inx 9240 16 due due IN cord-010092-uftc8inx 9240 17 to to IN cord-010092-uftc8inx 9240 18 the the DT cord-010092-uftc8inx 9240 19 difficulty difficulty NN cord-010092-uftc8inx 9240 20 in in IN cord-010092-uftc8inx 9240 21 finding find VBG cord-010092-uftc8inx 9240 22 compatible compatible JJ cord-010092-uftc8inx 9240 23 units unit NNS cord-010092-uftc8inx 9240 24 of of IN cord-010092-uftc8inx 9240 25 Red Red NNP cord-010092-uftc8inx 9240 26 Blood Blood NNP cord-010092-uftc8inx 9240 27 Cells cell NNS cord-010092-uftc8inx 9240 28 ( ( -LRB- cord-010092-uftc8inx 9240 29 RBCs rbc NNS cord-010092-uftc8inx 9240 30 ) ) -RRB- cord-010092-uftc8inx 9240 31 . . . cord-010092-uftc8inx 9241 1 In in IN cord-010092-uftc8inx 9241 2 patients patient NNS cord-010092-uftc8inx 9241 3 needing need VBG cord-010092-uftc8inx 9241 4 surgery surgery NN cord-010092-uftc8inx 9241 5 it -PRON- PRP cord-010092-uftc8inx 9241 6 is be VBZ cord-010092-uftc8inx 9241 7 important important JJ cord-010092-uftc8inx 9241 8 to to TO cord-010092-uftc8inx 9241 9 minimize minimize VB cord-010092-uftc8inx 9241 10 their -PRON- PRP$ cord-010092-uftc8inx 9241 11 transfusional transfusional JJ cord-010092-uftc8inx 9241 12 needs need NNS cord-010092-uftc8inx 9241 13 by by IN cord-010092-uftc8inx 9241 14 implementing implement VBG cord-010092-uftc8inx 9241 15 patient patient JJ cord-010092-uftc8inx 9241 16 blood blood NN cord-010092-uftc8inx 9241 17 management management NN cord-010092-uftc8inx 9241 18 programs program NNS cord-010092-uftc8inx 9241 19 ( ( -LRB- cord-010092-uftc8inx 9241 20 PBM PBM NNP cord-010092-uftc8inx 9241 21 ) ) -RRB- cord-010092-uftc8inx 9241 22 . . . cord-010092-uftc8inx 9242 1 Tests test NNS cord-010092-uftc8inx 9242 2 that that WDT cord-010092-uftc8inx 9242 3 predict predict VBP cord-010092-uftc8inx 9242 4 the the DT cord-010092-uftc8inx 9242 5 clinical clinical JJ cord-010092-uftc8inx 9242 6 significance significance NN cord-010092-uftc8inx 9242 7 of of IN cord-010092-uftc8inx 9242 8 antibodies antibody NNS cord-010092-uftc8inx 9242 9 , , , cord-010092-uftc8inx 9242 10 such such JJ cord-010092-uftc8inx 9242 11 as as IN cord-010092-uftc8inx 9242 12 monocyte monocyte NNP cord-010092-uftc8inx 9242 13 monolayer monolayer NN cord-010092-uftc8inx 9242 14 assay assay NN cord-010092-uftc8inx 9242 15 ( ( -LRB- cord-010092-uftc8inx 9242 16 MMA MMA NNP cord-010092-uftc8inx 9242 17 ) ) -RRB- cord-010092-uftc8inx 9242 18 are be VBP cord-010092-uftc8inx 9242 19 also also RB cord-010092-uftc8inx 9242 20 useful useful JJ cord-010092-uftc8inx 9242 21 in in IN cord-010092-uftc8inx 9242 22 guiding guide VBG cord-010092-uftc8inx 9242 23 clinical clinical JJ cord-010092-uftc8inx 9242 24 decisions decision NNS cord-010092-uftc8inx 9242 25 . . . cord-010092-uftc8inx 9243 1 Kell Kell NNP cord-010092-uftc8inx 9243 2 Blood Blood NNP cord-010092-uftc8inx 9243 3 Group Group NNP cord-010092-uftc8inx 9243 4 System System NNP cord-010092-uftc8inx 9243 5 contains contain VBZ cord-010092-uftc8inx 9243 6 highly highly RB cord-010092-uftc8inx 9243 7 immunogenic immunogenic JJ cord-010092-uftc8inx 9243 8 antigens antigen NNS cord-010092-uftc8inx 9243 9 . . . cord-010092-uftc8inx 9244 1 Antibodies antibody NNS cord-010092-uftc8inx 9244 2 against against IN cord-010092-uftc8inx 9244 3 these these DT cord-010092-uftc8inx 9244 4 antigens antigen NNS cord-010092-uftc8inx 9244 5 are be VBP cord-010092-uftc8inx 9244 6 Immunoglobulin Immunoglobulin NNP cord-010092-uftc8inx 9244 7 G G NNP cord-010092-uftc8inx 9244 8 , , , cord-010092-uftc8inx 9244 9 and and CC cord-010092-uftc8inx 9244 10 can can MD cord-010092-uftc8inx 9244 11 cause cause VB cord-010092-uftc8inx 9244 12 severe severe JJ cord-010092-uftc8inx 9244 13 hemolytic hemolytic JJ cord-010092-uftc8inx 9244 14 transfusion transfusion NN cord-010092-uftc8inx 9244 15 reactions reaction NNS cord-010092-uftc8inx 9244 16 and and CC cord-010092-uftc8inx 9244 17 fetal fetal JJ cord-010092-uftc8inx 9244 18 anemia anemia NN cord-010092-uftc8inx 9244 19 . . . cord-010092-uftc8inx 9245 1 Results result NNS cord-010092-uftc8inx 9245 2 : : : cord-010092-uftc8inx 9246 1 Case case NN cord-010092-uftc8inx 9246 2 report report VB cord-010092-uftc8inx 9247 1 We -PRON- PRP cord-010092-uftc8inx 9247 2 report report VBP cord-010092-uftc8inx 9247 3 the the DT cord-010092-uftc8inx 9247 4 case case NN cord-010092-uftc8inx 9247 5 of of IN cord-010092-uftc8inx 9247 6 a a DT cord-010092-uftc8inx 9247 7 75-year 75-year JJ cord-010092-uftc8inx 9247 8 - - HYPH cord-010092-uftc8inx 9247 9 old old JJ cord-010092-uftc8inx 9247 10 female female NN cord-010092-uftc8inx 9247 11 , , , cord-010092-uftc8inx 9247 12 with with IN cord-010092-uftc8inx 9247 13 Non Non NNP cord-010092-uftc8inx 9247 14 - - JJ cord-010092-uftc8inx 9247 15 Hodgkin Hodgkin NNP cord-010092-uftc8inx 9247 16 lymphoma lymphoma NN cord-010092-uftc8inx 9247 17 , , , cord-010092-uftc8inx 9247 18 chronic chronic JJ cord-010092-uftc8inx 9247 19 anemia anemia NN cord-010092-uftc8inx 9247 20 and and CC cord-010092-uftc8inx 9247 21 scoliosis scoliosis NN cord-010092-uftc8inx 9247 22 with with IN cord-010092-uftc8inx 9247 23 severe severe JJ cord-010092-uftc8inx 9247 24 neurological neurological JJ cord-010092-uftc8inx 9247 25 compromise compromise NN cord-010092-uftc8inx 9247 26 , , , cord-010092-uftc8inx 9247 27 proposed propose VBN cord-010092-uftc8inx 9247 28 for for IN cord-010092-uftc8inx 9247 29 lumbar lumbar JJ cord-010092-uftc8inx 9247 30 spinal spinal JJ cord-010092-uftc8inx 9247 31 stabilization stabilization NN cord-010092-uftc8inx 9247 32 surgery surgery NN cord-010092-uftc8inx 9247 33 . . . cord-010092-uftc8inx 9248 1 She -PRON- PRP cord-010092-uftc8inx 9248 2 had have VBD cord-010092-uftc8inx 9248 3 a a DT cord-010092-uftc8inx 9248 4 total total JJ cord-010092-uftc8inx 9248 5 hip hip NN cord-010092-uftc8inx 9248 6 replacement replacement NN cord-010092-uftc8inx 9248 7 surgery surgery NN cord-010092-uftc8inx 9248 8 in in IN cord-010092-uftc8inx 9248 9 2004 2004 CD cord-010092-uftc8inx 9248 10 , , , cord-010092-uftc8inx 9248 11 with with IN cord-010092-uftc8inx 9248 12 unknown unknown JJ cord-010092-uftc8inx 9248 13 transfusion transfusion NN cord-010092-uftc8inx 9248 14 history history NN cord-010092-uftc8inx 9248 15 . . . cord-010092-uftc8inx 9249 1 Her -PRON- PRP$ cord-010092-uftc8inx 9249 2 obstetric obstetric JJ cord-010092-uftc8inx 9249 3 history history NN cord-010092-uftc8inx 9249 4 was be VBD cord-010092-uftc8inx 9249 5 G6P4A2 G6P4A2 NNP cord-010092-uftc8inx 9249 6 . . . cord-010092-uftc8inx 9250 1 The the DT cord-010092-uftc8inx 9250 2 patient patient NN cord-010092-uftc8inx 9250 3 had have VBD cord-010092-uftc8inx 9250 4 no no DT cord-010092-uftc8inx 9250 5 history history NN cord-010092-uftc8inx 9250 6 of of IN cord-010092-uftc8inx 9250 7 thromboembolic thromboembolic JJ cord-010092-uftc8inx 9250 8 or or CC cord-010092-uftc8inx 9250 9 hemorrhagic hemorrhagic JJ cord-010092-uftc8inx 9250 10 events event NNS cord-010092-uftc8inx 9250 11 . . . cord-010092-uftc8inx 9251 1 During during IN cord-010092-uftc8inx 9251 2 pre pre JJ cord-010092-uftc8inx 9251 3 - - JJ cord-010092-uftc8inx 9251 4 transfusional transfusional JJ cord-010092-uftc8inx 9251 5 tests test NNS cord-010092-uftc8inx 9251 6 , , , cord-010092-uftc8inx 9251 7 she -PRON- PRP cord-010092-uftc8inx 9251 8 was be VBD cord-010092-uftc8inx 9251 9 typed type VBN cord-010092-uftc8inx 9251 10 as as IN cord-010092-uftc8inx 9251 11 a a DT cord-010092-uftc8inx 9251 12 0 0 CD cord-010092-uftc8inx 9251 13 rr rr NN cord-010092-uftc8inx 9251 14 and and CC cord-010092-uftc8inx 9251 15 had have VBD cord-010092-uftc8inx 9251 16 a a DT cord-010092-uftc8inx 9251 17 positive positive JJ cord-010092-uftc8inx 9251 18 antibody antibody NN cord-010092-uftc8inx 9251 19 screening screening NN cord-010092-uftc8inx 9251 20 test test NN cord-010092-uftc8inx 9251 21 . . . cord-010092-uftc8inx 9252 1 The the DT cord-010092-uftc8inx 9252 2 identification identification NN cord-010092-uftc8inx 9252 3 studies study NNS cord-010092-uftc8inx 9252 4 were be VBD cord-010092-uftc8inx 9252 5 suggestive suggestive JJ cord-010092-uftc8inx 9252 6 of of IN cord-010092-uftc8inx 9252 7 an an DT cord-010092-uftc8inx 9252 8 antibody antibody NN cord-010092-uftc8inx 9252 9 against against IN cord-010092-uftc8inx 9252 10 a a DT cord-010092-uftc8inx 9252 11 highincidence highincidence NN cord-010092-uftc8inx 9252 12 antigen antigen NN cord-010092-uftc8inx 9252 13 , , , cord-010092-uftc8inx 9252 14 so so IN cord-010092-uftc8inx 9252 15 the the DT cord-010092-uftc8inx 9252 16 surgery surgery NN cord-010092-uftc8inx 9252 17 was be VBD cord-010092-uftc8inx 9252 18 delayed delay VBN cord-010092-uftc8inx 9252 19 until until IN cord-010092-uftc8inx 9252 20 clarification clarification NN cord-010092-uftc8inx 9252 21 of of IN cord-010092-uftc8inx 9252 22 these these DT cord-010092-uftc8inx 9252 23 results result NNS cord-010092-uftc8inx 9252 24 . . . cord-010092-uftc8inx 9253 1 She -PRON- PRP cord-010092-uftc8inx 9253 2 was be VBD cord-010092-uftc8inx 9253 3 also also RB cord-010092-uftc8inx 9253 4 referred refer VBN cord-010092-uftc8inx 9253 5 to to IN cord-010092-uftc8inx 9253 6 a a DT cord-010092-uftc8inx 9253 7 PBM PBM NNP cord-010092-uftc8inx 9253 8 appointment appointment NN cord-010092-uftc8inx 9253 9 where where WRB cord-010092-uftc8inx 9253 10 her -PRON- PRP$ cord-010092-uftc8inx 9253 11 hemoglobin hemoglobin NN cord-010092-uftc8inx 9253 12 was be VBD cord-010092-uftc8inx 9253 13 improved improve VBN cord-010092-uftc8inx 9253 14 from from IN cord-010092-uftc8inx 9253 15 9.0 9.0 CD cord-010092-uftc8inx 9253 16 g g NN cord-010092-uftc8inx 9253 17 / / SYM cord-010092-uftc8inx 9253 18 dl dl NN cord-010092-uftc8inx 9253 19 to to IN cord-010092-uftc8inx 9253 20 12.0 12.0 CD cord-010092-uftc8inx 9253 21 g g NN cord-010092-uftc8inx 9253 22 / / SYM cord-010092-uftc8inx 9253 23 dl dl NNP cord-010092-uftc8inx 9253 24 by by IN cord-010092-uftc8inx 9253 25 administration administration NNP cord-010092-uftc8inx 9253 26 of of IN cord-010092-uftc8inx 9253 27 ferric ferric NNP cord-010092-uftc8inx 9253 28 carboxymaltose carboxymaltose NNP cord-010092-uftc8inx 9253 29 IV IV NNP cord-010092-uftc8inx 9253 30 and and CC cord-010092-uftc8inx 9253 31 darbepoetin darbepoetin NNP cord-010092-uftc8inx 9253 32 SC SC NNP cord-010092-uftc8inx 9253 33 . . . cord-010092-uftc8inx 9254 1 The the DT cord-010092-uftc8inx 9254 2 patient patient NN cord-010092-uftc8inx 9254 3 was be VBD cord-010092-uftc8inx 9254 4 phenotyped phenotype VBN cord-010092-uftc8inx 9254 5 as as IN cord-010092-uftc8inx 9254 6 Kp(a+b- Kp(a+b- NNP cord-010092-uftc8inx 9254 7 ) ) -RRB- cord-010092-uftc8inx 9254 8 with with IN cord-010092-uftc8inx 9254 9 anti anti JJ cord-010092-uftc8inx 9254 10 - - JJ cord-010092-uftc8inx 9254 11 Kpb kpb JJ cord-010092-uftc8inx 9254 12 , , , cord-010092-uftc8inx 9254 13 an an DT cord-010092-uftc8inx 9254 14 antibody antibody NN cord-010092-uftc8inx 9254 15 against against IN cord-010092-uftc8inx 9254 16 a a DT cord-010092-uftc8inx 9254 17 highincidence highincidence NN cord-010092-uftc8inx 9254 18 antigen antigen NN cord-010092-uftc8inx 9254 19 ( ( -LRB- cord-010092-uftc8inx 9254 20 > > NFP cord-010092-uftc8inx 9254 21 99 99 CD cord-010092-uftc8inx 9254 22 % % NN cord-010092-uftc8inx 9254 23 prevalence prevalence NN cord-010092-uftc8inx 9254 24 worldwide worldwide RB cord-010092-uftc8inx 9254 25 ) ) -RRB- cord-010092-uftc8inx 9254 26 . . . cord-010092-uftc8inx 9255 1 It -PRON- PRP cord-010092-uftc8inx 9255 2 is be VBZ cord-010092-uftc8inx 9255 3 a a DT cord-010092-uftc8inx 9255 4 rare rare JJ cord-010092-uftc8inx 9255 5 antibody antibody NN cord-010092-uftc8inx 9255 6 with with IN cord-010092-uftc8inx 9255 7 variable variable JJ cord-010092-uftc8inx 9255 8 reactivity reactivity NN cord-010092-uftc8inx 9255 9 , , , cord-010092-uftc8inx 9255 10 causing cause VBG cord-010092-uftc8inx 9255 11 from from IN cord-010092-uftc8inx 9255 12 none none NN cord-010092-uftc8inx 9255 13 to to TO cord-010092-uftc8inx 9255 14 moderate moderate VB cord-010092-uftc8inx 9255 15 / / SYM cord-010092-uftc8inx 9255 16 delayed delay VBN cord-010092-uftc8inx 9255 17 transfusion transfusion NN cord-010092-uftc8inx 9255 18 reactions reaction NNS cord-010092-uftc8inx 9255 19 . . . cord-010092-uftc8inx 9256 1 To to TO cord-010092-uftc8inx 9256 2 access access VB cord-010092-uftc8inx 9256 3 the the DT cord-010092-uftc8inx 9256 4 clinical clinical JJ cord-010092-uftc8inx 9256 5 significance significance NN cord-010092-uftc8inx 9256 6 of of IN cord-010092-uftc8inx 9256 7 this this DT cord-010092-uftc8inx 9256 8 antibody antibody NN cord-010092-uftc8inx 9256 9 , , , cord-010092-uftc8inx 9256 10 a a DT cord-010092-uftc8inx 9256 11 MMA MMA NNP cord-010092-uftc8inx 9256 12 was be VBD cord-010092-uftc8inx 9256 13 performed perform VBN cord-010092-uftc8inx 9256 14 , , , cord-010092-uftc8inx 9256 15 resulting result VBG cord-010092-uftc8inx 9256 16 in in IN cord-010092-uftc8inx 9256 17 a a DT cord-010092-uftc8inx 9256 18 reactivity reactivity NN cord-010092-uftc8inx 9256 19 of of IN cord-010092-uftc8inx 9256 20 1.2 1.2 CD cord-010092-uftc8inx 9256 21 % % NN cord-010092-uftc8inx 9256 22 , , , cord-010092-uftc8inx 9256 23 suggesting suggest VBG cord-010092-uftc8inx 9256 24 no no DT cord-010092-uftc8inx 9256 25 clinical clinical JJ cord-010092-uftc8inx 9256 26 relevance relevance NN cord-010092-uftc8inx 9256 27 , , , cord-010092-uftc8inx 9256 28 however however RB cord-010092-uftc8inx 9256 29 it -PRON- PRP cord-010092-uftc8inx 9256 30 could could MD cord-010092-uftc8inx 9256 31 be be VB cord-010092-uftc8inx 9256 32 altered alter VBN cord-010092-uftc8inx 9256 33 after after IN cord-010092-uftc8inx 9256 34 transfusion transfusion NN cord-010092-uftc8inx 9256 35 of of IN cord-010092-uftc8inx 9256 36 kpb+ kpb+ NNP cord-010092-uftc8inx 9256 37 blood blood NN cord-010092-uftc8inx 9256 38 . . . cord-010092-uftc8inx 9257 1 In in IN cord-010092-uftc8inx 9257 2 order order NN cord-010092-uftc8inx 9257 3 to to TO cord-010092-uftc8inx 9257 4 find find VB cord-010092-uftc8inx 9257 5 compatible compatible JJ cord-010092-uftc8inx 9257 6 RBC RBC NNP cord-010092-uftc8inx 9257 7 's 's POS cord-010092-uftc8inx 9257 8 , , , cord-010092-uftc8inx 9257 9 several several JJ cord-010092-uftc8inx 9257 10 family family NN cord-010092-uftc8inx 9257 11 members member NNS cord-010092-uftc8inx 9257 12 were be VBD cord-010092-uftc8inx 9257 13 phenotyped phenotype VBN cord-010092-uftc8inx 9257 14 , , , cord-010092-uftc8inx 9257 15 however however RB cord-010092-uftc8inx 9257 16 they -PRON- PRP cord-010092-uftc8inx 9257 17 were be VBD cord-010092-uftc8inx 9257 18 all all RB cord-010092-uftc8inx 9257 19 positive positive JJ cord-010092-uftc8inx 9257 20 to to IN cord-010092-uftc8inx 9257 21 the the DT cord-010092-uftc8inx 9257 22 Kpb Kpb NNP cord-010092-uftc8inx 9257 23 antigen antigen NN cord-010092-uftc8inx 9257 24 . . . cord-010092-uftc8inx 9258 1 In in IN cord-010092-uftc8inx 9258 2 Portugal Portugal NNP cord-010092-uftc8inx 9258 3 there there EX cord-010092-uftc8inx 9258 4 were be VBD cord-010092-uftc8inx 9258 5 no no DT cord-010092-uftc8inx 9258 6 0 0 CD cord-010092-uftc8inx 9258 7 rr rr NN cord-010092-uftc8inx 9258 8 Kp(b- kp(b- CD cord-010092-uftc8inx 9258 9 ) ) -RRB- cord-010092-uftc8inx 9258 10 blood blood NN cord-010092-uftc8inx 9258 11 donors donor NNS cord-010092-uftc8inx 9258 12 , , , cord-010092-uftc8inx 9258 13 as as IN cord-010092-uftc8inx 9258 14 it -PRON- PRP cord-010092-uftc8inx 9258 15 is be VBZ cord-010092-uftc8inx 9258 16 extremely extremely RB cord-010092-uftc8inx 9258 17 rare rare JJ cord-010092-uftc8inx 9258 18 , , , cord-010092-uftc8inx 9258 19 so so RB cord-010092-uftc8inx 9258 20 we -PRON- PRP cord-010092-uftc8inx 9258 21 searched search VBD cord-010092-uftc8inx 9258 22 in in IN cord-010092-uftc8inx 9258 23 the the DT cord-010092-uftc8inx 9258 24 International International NNP cord-010092-uftc8inx 9258 25 Rare Rare NNP cord-010092-uftc8inx 9258 26 Donor Donor NNP cord-010092-uftc8inx 9258 27 Panel Panel NNP cord-010092-uftc8inx 9258 28 ( ( -LRB- cord-010092-uftc8inx 9258 29 IRDP IRDP NNP cord-010092-uftc8inx 9258 30 ) ) -RRB- cord-010092-uftc8inx 9258 31 and and CC cord-010092-uftc8inx 9258 32 two two CD cord-010092-uftc8inx 9258 33 donors donor NNS cord-010092-uftc8inx 9258 34 were be VBD cord-010092-uftc8inx 9258 35 found find VBN cord-010092-uftc8inx 9258 36 in in IN cord-010092-uftc8inx 9258 37 Spain Spain NNP cord-010092-uftc8inx 9258 38 . . . cord-010092-uftc8inx 9259 1 Two two CD cord-010092-uftc8inx 9259 2 units unit NNS cord-010092-uftc8inx 9259 3 of of IN cord-010092-uftc8inx 9259 4 compatible compatible JJ cord-010092-uftc8inx 9259 5 RBC RBC NNP cord-010092-uftc8inx 9259 6 's 's POS cord-010092-uftc8inx 9259 7 were be VBD cord-010092-uftc8inx 9259 8 requested request VBN cord-010092-uftc8inx 9259 9 prior prior RB cord-010092-uftc8inx 9259 10 to to IN cord-010092-uftc8inx 9259 11 the the DT cord-010092-uftc8inx 9259 12 surgery surgery NN cord-010092-uftc8inx 9259 13 , , , cord-010092-uftc8inx 9259 14 which which WDT cord-010092-uftc8inx 9259 15 was be VBD cord-010092-uftc8inx 9259 16 performed perform VBN cord-010092-uftc8inx 9259 17 successfully successfully RB cord-010092-uftc8inx 9259 18 four four CD cord-010092-uftc8inx 9259 19 months month NNS cord-010092-uftc8inx 9259 20 later later RB cord-010092-uftc8inx 9259 21 without without IN cord-010092-uftc8inx 9259 22 transfusional transfusional JJ cord-010092-uftc8inx 9259 23 support support NN cord-010092-uftc8inx 9259 24 . . . cord-010092-uftc8inx 9260 1 Summary Summary NNP cord-010092-uftc8inx 9260 2 / / SYM cord-010092-uftc8inx 9260 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 9260 4 : : : cord-010092-uftc8inx 9261 1 Anti anti JJ cord-010092-uftc8inx 9261 2 - - NNP cord-010092-uftc8inx 9261 3 Kpb Kpb NNP cord-010092-uftc8inx 9261 4 is be VBZ cord-010092-uftc8inx 9261 5 a a DT cord-010092-uftc8inx 9261 6 rare rare JJ cord-010092-uftc8inx 9261 7 antibody antibody NN cord-010092-uftc8inx 9261 8 that that IN cord-010092-uftc8inx 9261 9 in in IN cord-010092-uftc8inx 9261 10 some some DT cord-010092-uftc8inx 9261 11 cases case NNS cord-010092-uftc8inx 9261 12 can can MD cord-010092-uftc8inx 9261 13 cause cause VB cord-010092-uftc8inx 9261 14 hemolysis hemolysis NN cord-010092-uftc8inx 9261 15 of of IN cord-010092-uftc8inx 9261 16 the the DT cord-010092-uftc8inx 9261 17 transfused transfuse VBN cord-010092-uftc8inx 9261 18 Kp(b+ Kp(b+ NNP cord-010092-uftc8inx 9261 19 ) ) -RRB- cord-010092-uftc8inx 9261 20 red red JJ cord-010092-uftc8inx 9261 21 blood blood NN cord-010092-uftc8inx 9261 22 cells cell NNS cord-010092-uftc8inx 9261 23 . . . cord-010092-uftc8inx 9262 1 The the DT cord-010092-uftc8inx 9262 2 combination combination NN cord-010092-uftc8inx 9262 3 of of IN cord-010092-uftc8inx 9262 4 Kp(b- kp(b- CD cord-010092-uftc8inx 9262 5 ) ) -RRB- cord-010092-uftc8inx 9262 6 and and CC cord-010092-uftc8inx 9262 7 O o UH cord-010092-uftc8inx 9262 8 rr rr NN cord-010092-uftc8inx 9262 9 , , , cord-010092-uftc8inx 9262 10 an an DT cord-010092-uftc8inx 9262 11 extremely extremely RB cord-010092-uftc8inx 9262 12 rare rare JJ cord-010092-uftc8inx 9262 13 phenotype phenotype NN cord-010092-uftc8inx 9262 14 , , , cord-010092-uftc8inx 9262 15 presented present VBD cord-010092-uftc8inx 9262 16 a a DT cord-010092-uftc8inx 9262 17 challenge challenge NN cord-010092-uftc8inx 9262 18 in in IN cord-010092-uftc8inx 9262 19 finding find VBG cord-010092-uftc8inx 9262 20 compatible compatible JJ cord-010092-uftc8inx 9262 21 RBCs rbc NNS cord-010092-uftc8inx 9262 22 . . . cord-010092-uftc8inx 9263 1 This this DT cord-010092-uftc8inx 9263 2 case case NN cord-010092-uftc8inx 9263 3 illustrates illustrate VBZ cord-010092-uftc8inx 9263 4 not not RB cord-010092-uftc8inx 9263 5 only only RB cord-010092-uftc8inx 9263 6 the the DT cord-010092-uftc8inx 9263 7 complex complex JJ cord-010092-uftc8inx 9263 8 transfusional transfusional JJ cord-010092-uftc8inx 9263 9 and and CC cord-010092-uftc8inx 9263 10 logistic logistic JJ cord-010092-uftc8inx 9263 11 problems problem NNS cord-010092-uftc8inx 9263 12 that that WDT cord-010092-uftc8inx 9263 13 an an DT cord-010092-uftc8inx 9263 14 antibody antibody NN cord-010092-uftc8inx 9263 15 against against IN cord-010092-uftc8inx 9263 16 a a DT cord-010092-uftc8inx 9263 17 high high JJ cord-010092-uftc8inx 9263 18 - - HYPH cord-010092-uftc8inx 9263 19 incidence incidence NN cord-010092-uftc8inx 9263 20 antigen antigen NN cord-010092-uftc8inx 9263 21 can can MD cord-010092-uftc8inx 9263 22 pose pose VB cord-010092-uftc8inx 9263 23 , , , cord-010092-uftc8inx 9263 24 but but CC cord-010092-uftc8inx 9263 25 also also RB cord-010092-uftc8inx 9263 26 the the DT cord-010092-uftc8inx 9263 27 importance importance NN cord-010092-uftc8inx 9263 28 of of IN cord-010092-uftc8inx 9263 29 an an DT cord-010092-uftc8inx 9263 30 efficient efficient JJ cord-010092-uftc8inx 9263 31 PBM PBM NNP cord-010092-uftc8inx 9263 32 programme programme NN cord-010092-uftc8inx 9263 33 to to TO cord-010092-uftc8inx 9263 34 mitigate mitigate VB cord-010092-uftc8inx 9263 35 the the DT cord-010092-uftc8inx 9263 36 transfusional transfusional NNP cord-010092-uftc8inx 9263 37 needs need NNS cord-010092-uftc8inx 9263 38 in in IN cord-010092-uftc8inx 9263 39 these these DT cord-010092-uftc8inx 9263 40 patients patient NNS cord-010092-uftc8inx 9263 41 . . . cord-010092-uftc8inx 9264 1 Background background NN cord-010092-uftc8inx 9264 2 : : : cord-010092-uftc8inx 9265 1 Blood blood NN cord-010092-uftc8inx 9265 2 transfusion transfusion NN cord-010092-uftc8inx 9265 3 is be VBZ cord-010092-uftc8inx 9265 4 an an DT cord-010092-uftc8inx 9265 5 integral integral JJ cord-010092-uftc8inx 9265 6 part part NN cord-010092-uftc8inx 9265 7 of of IN cord-010092-uftc8inx 9265 8 the the DT cord-010092-uftc8inx 9265 9 supportive supportive JJ cord-010092-uftc8inx 9265 10 care care NN cord-010092-uftc8inx 9265 11 for for IN cord-010092-uftc8inx 9265 12 patients patient NNS cord-010092-uftc8inx 9265 13 with with IN cord-010092-uftc8inx 9265 14 sickle sickle NN cord-010092-uftc8inx 9265 15 cell cell NN cord-010092-uftc8inx 9265 16 disease disease NN cord-010092-uftc8inx 9265 17 ( ( -LRB- cord-010092-uftc8inx 9265 18 SCD SCD NNP cord-010092-uftc8inx 9265 19 ) ) -RRB- cord-010092-uftc8inx 9265 20 . . . cord-010092-uftc8inx 9266 1 Allo allo NN cord-010092-uftc8inx 9266 2 - - HYPH cord-010092-uftc8inx 9266 3 immunization immunization NN cord-010092-uftc8inx 9266 4 is be VBZ cord-010092-uftc8inx 9266 5 a a DT cord-010092-uftc8inx 9266 6 recognized recognize VBN cord-010092-uftc8inx 9266 7 complication complication NN cord-010092-uftc8inx 9266 8 to to IN cord-010092-uftc8inx 9266 9 red red JJ cord-010092-uftc8inx 9266 10 blood blood NN cord-010092-uftc8inx 9266 11 cells cell NNS cord-010092-uftc8inx 9266 12 transfusion transfusion NN cord-010092-uftc8inx 9266 13 ( ( -LRB- cord-010092-uftc8inx 9266 14 RBC RBC NNP cord-010092-uftc8inx 9266 15 ) ) -RRB- cord-010092-uftc8inx 9266 16 in in IN cord-010092-uftc8inx 9266 17 those those DT cord-010092-uftc8inx 9266 18 patients patient NNS cord-010092-uftc8inx 9266 19 . . . cord-010092-uftc8inx 9267 1 This this DT cord-010092-uftc8inx 9267 2 may may MD cord-010092-uftc8inx 9267 3 result result VB cord-010092-uftc8inx 9267 4 in in IN cord-010092-uftc8inx 9267 5 difficulties difficulty NNS cord-010092-uftc8inx 9267 6 in in IN cord-010092-uftc8inx 9267 7 providing provide VBG cord-010092-uftc8inx 9267 8 compatible compatible JJ cord-010092-uftc8inx 9267 9 blood blood NN cord-010092-uftc8inx 9267 10 , , , cord-010092-uftc8inx 9267 11 and and CC cord-010092-uftc8inx 9267 12 may may MD cord-010092-uftc8inx 9267 13 be be VB cord-010092-uftc8inx 9267 14 associated associate VBN cord-010092-uftc8inx 9267 15 with with IN cord-010092-uftc8inx 9267 16 the the DT cord-010092-uftc8inx 9267 17 risk risk NN cord-010092-uftc8inx 9267 18 of of IN cord-010092-uftc8inx 9267 19 acute acute NN cord-010092-uftc8inx 9267 20 of of IN cord-010092-uftc8inx 9267 21 delayed delayed JJ cord-010092-uftc8inx 9267 22 hemolytic hemolytic JJ cord-010092-uftc8inx 9267 23 transfusion transfusion NN cord-010092-uftc8inx 9267 24 reactions reaction NNS cord-010092-uftc8inx 9267 25 . . . cord-010092-uftc8inx 9268 1 Aims aim VBZ cord-010092-uftc8inx 9268 2 : : : cord-010092-uftc8inx 9268 3 To to TO cord-010092-uftc8inx 9268 4 describe describe VB cord-010092-uftc8inx 9268 5 transfusion transfusion NN cord-010092-uftc8inx 9268 6 management management NN cord-010092-uftc8inx 9268 7 in in IN cord-010092-uftc8inx 9268 8 a a DT cord-010092-uftc8inx 9268 9 patient patient NN cord-010092-uftc8inx 9268 10 with with IN cord-010092-uftc8inx 9268 11 SCD SCD NNP cord-010092-uftc8inx 9268 12 who who WP cord-010092-uftc8inx 9268 13 has have VBZ cord-010092-uftc8inx 9268 14 multiple multiple JJ cord-010092-uftc8inx 9268 15 alloantibodies alloantibody NNS cord-010092-uftc8inx 9268 16 with with IN cord-010092-uftc8inx 9268 17 difficulty difficulty NN cord-010092-uftc8inx 9268 18 in in IN cord-010092-uftc8inx 9268 19 obtaining obtain VBG cord-010092-uftc8inx 9268 20 compatible compatible JJ cord-010092-uftc8inx 9268 21 blood blood NN cord-010092-uftc8inx 9268 22 , , , cord-010092-uftc8inx 9268 23 in in IN cord-010092-uftc8inx 9268 24 order order NN cord-010092-uftc8inx 9268 25 to to TO cord-010092-uftc8inx 9268 26 highlight highlight VB cord-010092-uftc8inx 9268 27 the the DT cord-010092-uftc8inx 9268 28 importance importance NN cord-010092-uftc8inx 9268 29 and and CC cord-010092-uftc8inx 9268 30 clinical clinical JJ cord-010092-uftc8inx 9268 31 consequences consequence NNS cord-010092-uftc8inx 9268 32 of of IN cord-010092-uftc8inx 9268 33 this this DT cord-010092-uftc8inx 9268 34 complication complication NN cord-010092-uftc8inx 9268 35 and and CC cord-010092-uftc8inx 9268 36 suggest suggest VBP cord-010092-uftc8inx 9268 37 a a DT cord-010092-uftc8inx 9268 38 possible possible JJ cord-010092-uftc8inx 9268 39 management management NN cord-010092-uftc8inx 9268 40 approach approach NN cord-010092-uftc8inx 9268 41 Methods method NNS cord-010092-uftc8inx 9268 42 : : : cord-010092-uftc8inx 9269 1 An an DT cord-010092-uftc8inx 9269 2 18-years 18-years JJ cord-010092-uftc8inx 9269 3 - - HYPH cord-010092-uftc8inx 9269 4 old old JJ cord-010092-uftc8inx 9269 5 female female JJ cord-010092-uftc8inx 9269 6 patient patient NN cord-010092-uftc8inx 9269 7 with with IN cord-010092-uftc8inx 9269 8 SCD SCD NNP cord-010092-uftc8inx 9269 9 presented present VBN cord-010092-uftc8inx 9269 10 to to IN cord-010092-uftc8inx 9269 11 our -PRON- PRP$ cord-010092-uftc8inx 9269 12 hospital hospital NN cord-010092-uftc8inx 9269 13 with with IN cord-010092-uftc8inx 9269 14 hemoglobin hemoglobin NN cord-010092-uftc8inx 9269 15 level level NN cord-010092-uftc8inx 9269 16 of of IN cord-010092-uftc8inx 9269 17 4 4 CD cord-010092-uftc8inx 9269 18 g g NN cord-010092-uftc8inx 9269 19 / / SYM cord-010092-uftc8inx 9269 20 dl dl NN cord-010092-uftc8inx 9269 21 secondary secondary JJ cord-010092-uftc8inx 9269 22 to to IN cord-010092-uftc8inx 9269 23 acute acute JJ cord-010092-uftc8inx 9269 24 splenic splenic JJ cord-010092-uftc8inx 9269 25 sequestration sequestration NN cord-010092-uftc8inx 9269 26 . . . cord-010092-uftc8inx 9270 1 She -PRON- PRP cord-010092-uftc8inx 9270 2 had have VBD cord-010092-uftc8inx 9270 3 a a DT cord-010092-uftc8inx 9270 4 history history NN cord-010092-uftc8inx 9270 5 of of IN cord-010092-uftc8inx 9270 6 multiple multiple JJ cord-010092-uftc8inx 9270 7 previous previous JJ cord-010092-uftc8inx 9270 8 admissions admission NNS cord-010092-uftc8inx 9270 9 and and CC cord-010092-uftc8inx 9270 10 many many JJ cord-010092-uftc8inx 9270 11 previous previous JJ cord-010092-uftc8inx 9270 12 RBC RBC NNP cord-010092-uftc8inx 9270 13 transfusions transfusion NNS cord-010092-uftc8inx 9270 14 . . . cord-010092-uftc8inx 9271 1 Blood blood NN cord-010092-uftc8inx 9271 2 grouping grouping NN cord-010092-uftc8inx 9271 3 and and CC cord-010092-uftc8inx 9271 4 pre pre JJ cord-010092-uftc8inx 9271 5 - - JJ cord-010092-uftc8inx 9271 6 transfusion transfusion JJ cord-010092-uftc8inx 9271 7 compatibility compatibility NN cord-010092-uftc8inx 9271 8 testing testing NN cord-010092-uftc8inx 9271 9 were be VBD cord-010092-uftc8inx 9271 10 performed perform VBN cord-010092-uftc8inx 9271 11 in in IN cord-010092-uftc8inx 9271 12 addition addition NN cord-010092-uftc8inx 9271 13 to to IN cord-010092-uftc8inx 9271 14 phenotyping phenotyping NN cord-010092-uftc8inx 9271 15 of of IN cord-010092-uftc8inx 9271 16 the the DT cord-010092-uftc8inx 9271 17 patient patient NN cord-010092-uftc8inx 9271 18 's 's POS cord-010092-uftc8inx 9271 19 red red JJ cord-010092-uftc8inx 9271 20 cells cell NNS cord-010092-uftc8inx 9271 21 . . . cord-010092-uftc8inx 9272 1 Screening screening NN cord-010092-uftc8inx 9272 2 was be VBD cord-010092-uftc8inx 9272 3 done do VBN cord-010092-uftc8inx 9272 4 using use VBG cord-010092-uftc8inx 9272 5 column column NN cord-010092-uftc8inx 9272 6 agglutination agglutination NN cord-010092-uftc8inx 9272 7 technique technique NN cord-010092-uftc8inx 9272 8 by by IN cord-010092-uftc8inx 9272 9 automated automate VBN cord-010092-uftc8inx 9272 10 machine machine NN cord-010092-uftc8inx 9272 11 ( ( -LRB- cord-010092-uftc8inx 9272 12 Ortho Ortho NNP cord-010092-uftc8inx 9272 13 ; ; : cord-010092-uftc8inx 9272 14 USA USA NNP cord-010092-uftc8inx 9272 15 ) ) -RRB- cord-010092-uftc8inx 9272 16 and and CC cord-010092-uftc8inx 9272 17 antibody antibody NN cord-010092-uftc8inx 9272 18 identification identification NN cord-010092-uftc8inx 9272 19 was be VBD cord-010092-uftc8inx 9272 20 performed perform VBN cord-010092-uftc8inx 9272 21 manually manually RB cord-010092-uftc8inx 9272 22 using use VBG cord-010092-uftc8inx 9272 23 commercial commercial JJ cord-010092-uftc8inx 9272 24 11 11 CD cord-010092-uftc8inx 9272 25 cells cell NNS cord-010092-uftc8inx 9272 26 identification identification NN cord-010092-uftc8inx 9272 27 panel panel NN cord-010092-uftc8inx 9272 28 . . . cord-010092-uftc8inx 9273 1 Phenotyping phenotyping NN cord-010092-uftc8inx 9273 2 for for IN cord-010092-uftc8inx 9273 3 the the DT cord-010092-uftc8inx 9273 4 patient patient NN cord-010092-uftc8inx 9273 5 was be VBD cord-010092-uftc8inx 9273 6 done do VBN cord-010092-uftc8inx 9273 7 using use VBG cord-010092-uftc8inx 9273 8 haemagglutination haemagglutination NN cord-010092-uftc8inx 9273 9 technique technique NN cord-010092-uftc8inx 9273 10 with with IN cord-010092-uftc8inx 9273 11 mono mono JJ cord-010092-uftc8inx 9273 12 - - HYPH cord-010092-uftc8inx 9273 13 specific specific JJ cord-010092-uftc8inx 9273 14 anti anti FW cord-010092-uftc8inx 9273 15 sera sera NNP cord-010092-uftc8inx 9274 1 ( ( -LRB- cord-010092-uftc8inx 9274 2 Bio Bio NNP cord-010092-uftc8inx 9274 3 - - HYPH cord-010092-uftc8inx 9274 4 Rad Rad NNP cord-010092-uftc8inx 9274 5 ; ; : cord-010092-uftc8inx 9274 6 Switzerland Switzerland NNP cord-010092-uftc8inx 9274 7 ) ) -RRB- cord-010092-uftc8inx 9274 8 . . . cord-010092-uftc8inx 9275 1 Results result NNS cord-010092-uftc8inx 9275 2 : : : cord-010092-uftc8inx 9276 1 The the DT cord-010092-uftc8inx 9276 2 patient patient NN cord-010092-uftc8inx 9276 3 was be VBD cord-010092-uftc8inx 9276 4 of of IN cord-010092-uftc8inx 9276 5 group group NN cord-010092-uftc8inx 9276 6 O o NN cord-010092-uftc8inx 9276 7 RhD rhd NN cord-010092-uftc8inx 9276 8 ( ( -LRB- cord-010092-uftc8inx 9276 9 positive positive JJ cord-010092-uftc8inx 9276 10 ) ) -RRB- cord-010092-uftc8inx 9276 11 . . . cord-010092-uftc8inx 9277 1 Antibody antibody NN cord-010092-uftc8inx 9277 2 screening screening NN cord-010092-uftc8inx 9277 3 was be VBD cord-010092-uftc8inx 9277 4 positive positive JJ cord-010092-uftc8inx 9277 5 and and CC cord-010092-uftc8inx 9277 6 antibody antibody NN cord-010092-uftc8inx 9277 7 identification identification NN cord-010092-uftc8inx 9277 8 revealed reveal VBD cord-010092-uftc8inx 9277 9 probable probable JJ cord-010092-uftc8inx 9277 10 anti anti JJ cord-010092-uftc8inx 9277 11 - - JJ cord-010092-uftc8inx 9277 12 E e JJ cord-010092-uftc8inx 9277 13 and and CC cord-010092-uftc8inx 9277 14 anti anti JJ cord-010092-uftc8inx 9277 15 - - JJ cord-010092-uftc8inx 9277 16 Fya Fya NNP cord-010092-uftc8inx 9277 17 with with IN cord-010092-uftc8inx 9277 18 possible possible JJ cord-010092-uftc8inx 9277 19 development development NN cord-010092-uftc8inx 9277 20 of of IN cord-010092-uftc8inx 9277 21 anti anti JJ cord-010092-uftc8inx 9277 22 - - JJ cord-010092-uftc8inx 9277 23 K k JJ cord-010092-uftc8inx 9277 24 allo allo NN cord-010092-uftc8inx 9277 25 - - HYPH cord-010092-uftc8inx 9277 26 antibodies antibody NNS cord-010092-uftc8inx 9277 27 , , , cord-010092-uftc8inx 9277 28 in in IN cord-010092-uftc8inx 9277 29 addition addition NN cord-010092-uftc8inx 9277 30 to to IN cord-010092-uftc8inx 9277 31 recent recent JJ cord-010092-uftc8inx 9277 32 development development NN cord-010092-uftc8inx 9277 33 of of IN cord-010092-uftc8inx 9277 34 autoantibodies autoantibody NNS cord-010092-uftc8inx 9277 35 ; ; : cord-010092-uftc8inx 9277 36 giving give VBG cord-010092-uftc8inx 9277 37 pan pan JJ cord-010092-uftc8inx 9277 38 - - JJ cord-010092-uftc8inx 9277 39 positive positive JJ cord-010092-uftc8inx 9277 40 reactivity reactivity NN cord-010092-uftc8inx 9277 41 with with IN cord-010092-uftc8inx 9277 42 the the DT cord-010092-uftc8inx 9277 43 identification identification NN cord-010092-uftc8inx 9277 44 panels panel NNS cord-010092-uftc8inx 9277 45 . . . cord-010092-uftc8inx 9278 1 Phenotyping phenotyping NN cord-010092-uftc8inx 9278 2 of of IN cord-010092-uftc8inx 9278 3 the the DT cord-010092-uftc8inx 9278 4 patient patient NN cord-010092-uftc8inx 9278 5 's 's POS cord-010092-uftc8inx 9278 6 RBCs rbc NNS cord-010092-uftc8inx 9278 7 was be VBD cord-010092-uftc8inx 9278 8 found find VBN cord-010092-uftc8inx 9278 9 to to TO cord-010092-uftc8inx 9278 10 be be VB cord-010092-uftc8inx 9278 11 R1r r1r JJ cord-010092-uftc8inx 9278 12 and and CC cord-010092-uftc8inx 9278 13 K k NN cord-010092-uftc8inx 9278 14 - - HYPH cord-010092-uftc8inx 9278 15 negative negative JJ cord-010092-uftc8inx 9278 16 . . . cord-010092-uftc8inx 9279 1 Other other JJ cord-010092-uftc8inx 9279 2 masked masked JJ cord-010092-uftc8inx 9279 3 allo allo NN cord-010092-uftc8inx 9279 4 - - HYPH cord-010092-uftc8inx 9279 5 antibodies antibody NNS cord-010092-uftc8inx 9279 6 of of IN cord-010092-uftc8inx 9279 7 undefined undefined JJ cord-010092-uftc8inx 9279 8 specificities specificity NNS cord-010092-uftc8inx 9279 9 were be VBD cord-010092-uftc8inx 9279 10 suspected suspect VBN cord-010092-uftc8inx 9279 11 and and CC cord-010092-uftc8inx 9279 12 no no DT cord-010092-uftc8inx 9279 13 compatible compatible JJ cord-010092-uftc8inx 9279 14 blood blood NN cord-010092-uftc8inx 9279 15 was be VBD cord-010092-uftc8inx 9279 16 found find VBN cord-010092-uftc8inx 9279 17 . . . cord-010092-uftc8inx 9280 1 The the DT cord-010092-uftc8inx 9280 2 clinical clinical JJ cord-010092-uftc8inx 9280 3 condition condition NN cord-010092-uftc8inx 9280 4 warranted warrant VBD cord-010092-uftc8inx 9280 5 a a DT cord-010092-uftc8inx 9280 6 blood blood NN cord-010092-uftc8inx 9280 7 transfusion transfusion NN cord-010092-uftc8inx 9280 8 , , , cord-010092-uftc8inx 9280 9 so so RB cord-010092-uftc8inx 9280 10 least least JJS cord-010092-uftc8inx 9280 11 incompatible incompatible JJ cord-010092-uftc8inx 9280 12 phenotypically phenotypically RB cord-010092-uftc8inx 9280 13 matched match VBN cord-010092-uftc8inx 9280 14 RBC RBC NNP cord-010092-uftc8inx 9280 15 unit unit NN cord-010092-uftc8inx 9280 16 was be VBD cord-010092-uftc8inx 9280 17 released release VBN cord-010092-uftc8inx 9280 18 . . . cord-010092-uftc8inx 9281 1 The the DT cord-010092-uftc8inx 9281 2 patient patient NN cord-010092-uftc8inx 9281 3 developed develop VBD cord-010092-uftc8inx 9281 4 acute acute JJ cord-010092-uftc8inx 9281 5 hemolytic hemolytic JJ cord-010092-uftc8inx 9281 6 transfusion transfusion NN cord-010092-uftc8inx 9281 7 reaction reaction NN cord-010092-uftc8inx 9281 8 with with IN cord-010092-uftc8inx 9281 9 drop drop NN cord-010092-uftc8inx 9281 10 of of IN cord-010092-uftc8inx 9281 11 the the DT cord-010092-uftc8inx 9281 12 Hb Hb NNP cord-010092-uftc8inx 9281 13 level level NN cord-010092-uftc8inx 9281 14 to to IN cord-010092-uftc8inx 9281 15 2.8 2.8 CD cord-010092-uftc8inx 9281 16 g g NN cord-010092-uftc8inx 9281 17 / / SYM cord-010092-uftc8inx 9281 18 dl dl NN cord-010092-uftc8inx 9281 19 . . . cord-010092-uftc8inx 9282 1 Despite despite IN cord-010092-uftc8inx 9282 2 screening screen VBG cord-010092-uftc8inx 9282 3 hundreds hundred NNS cord-010092-uftc8inx 9282 4 of of IN cord-010092-uftc8inx 9282 5 RBC RBC NNP cord-010092-uftc8inx 9282 6 units unit NNS cord-010092-uftc8inx 9282 7 , , , cord-010092-uftc8inx 9282 8 no no DT cord-010092-uftc8inx 9282 9 compatible compatible JJ cord-010092-uftc8inx 9282 10 units unit NNS cord-010092-uftc8inx 9282 11 were be VBD cord-010092-uftc8inx 9282 12 identified identify VBN cord-010092-uftc8inx 9282 13 , , , cord-010092-uftc8inx 9282 14 and and CC cord-010092-uftc8inx 9282 15 no no DT cord-010092-uftc8inx 9282 16 transfusion transfusion NN cord-010092-uftc8inx 9282 17 was be VBD cord-010092-uftc8inx 9282 18 given give VBN cord-010092-uftc8inx 9282 19 . . . cord-010092-uftc8inx 9283 1 The the DT cord-010092-uftc8inx 9283 2 patient patient NN cord-010092-uftc8inx 9283 3 was be VBD cord-010092-uftc8inx 9283 4 managed manage VBN cord-010092-uftc8inx 9283 5 conservatively conservatively RB cord-010092-uftc8inx 9283 6 using use VBG cord-010092-uftc8inx 9283 7 hydration hydration NN cord-010092-uftc8inx 9283 8 , , , cord-010092-uftc8inx 9283 9 analgesics analgesic NNS cord-010092-uftc8inx 9283 10 , , , cord-010092-uftc8inx 9283 11 hydroxyurea hydroxyurea NNP cord-010092-uftc8inx 9283 12 , , , cord-010092-uftc8inx 9283 13 erythropoietin erythropoietin NN cord-010092-uftc8inx 9283 14 , , , cord-010092-uftc8inx 9283 15 Intravenous Intravenous NNP cord-010092-uftc8inx 9283 16 Immune Immune NNP cord-010092-uftc8inx 9283 17 Globulin Globulin NNP cord-010092-uftc8inx 9283 18 ( ( -LRB- cord-010092-uftc8inx 9283 19 IVIG IVIG NNP cord-010092-uftc8inx 9283 20 ) ) -RRB- cord-010092-uftc8inx 9283 21 , , , cord-010092-uftc8inx 9283 22 steroids steroid NNS cord-010092-uftc8inx 9283 23 , , , cord-010092-uftc8inx 9283 24 and and CC cord-010092-uftc8inx 9283 25 rituximab rituximab NN cord-010092-uftc8inx 9283 26 . . . cord-010092-uftc8inx 9284 1 Hb Hb NNP cord-010092-uftc8inx 9284 2 level level NN cord-010092-uftc8inx 9284 3 increased increase VBD cord-010092-uftc8inx 9284 4 to to IN cord-010092-uftc8inx 9284 5 8 8 CD cord-010092-uftc8inx 9284 6 g g NN cord-010092-uftc8inx 9284 7 / / SYM cord-010092-uftc8inx 9284 8 dl dl NN cord-010092-uftc8inx 9284 9 in in IN cord-010092-uftc8inx 9284 10 2 2 CD cord-010092-uftc8inx 9284 11 weeks week NNS cord-010092-uftc8inx 9284 12 , , , cord-010092-uftc8inx 9284 13 and and CC cord-010092-uftc8inx 9284 14 the the DT cord-010092-uftc8inx 9284 15 patient patient NN cord-010092-uftc8inx 9284 16 was be VBD cord-010092-uftc8inx 9284 17 discharged discharge VBN cord-010092-uftc8inx 9284 18 from from IN cord-010092-uftc8inx 9284 19 the the DT cord-010092-uftc8inx 9284 20 hospital hospital NN cord-010092-uftc8inx 9284 21 . . . cord-010092-uftc8inx 9285 1 The the DT cord-010092-uftc8inx 9285 2 sample sample NN cord-010092-uftc8inx 9285 3 of of IN cord-010092-uftc8inx 9285 4 the the DT cord-010092-uftc8inx 9285 5 patient patient NN cord-010092-uftc8inx 9285 6 was be VBD cord-010092-uftc8inx 9285 7 sent send VBN cord-010092-uftc8inx 9285 8 to to IN cord-010092-uftc8inx 9285 9 a a DT cord-010092-uftc8inx 9285 10 reference reference NN cord-010092-uftc8inx 9285 11 lab lab NN cord-010092-uftc8inx 9286 1 ( ( -LRB- cord-010092-uftc8inx 9286 2 Institut Institut NNP cord-010092-uftc8inx 9286 3 fur fur NN cord-010092-uftc8inx 9286 4 Klinische Klinische NNP cord-010092-uftc8inx 9286 5 Chemie Chemie NNP cord-010092-uftc8inx 9286 6 und und XX cord-010092-uftc8inx 9287 1 Laboratoriumsmedizin Laboratoriumsmedizin NNP cord-010092-uftc8inx 9287 2 - - HYPH cord-010092-uftc8inx 9287 3 Regensburg Regensburg NNP cord-010092-uftc8inx 9288 1 -Germany -germany LS cord-010092-uftc8inx 9288 2 ) ) -RRB- cord-010092-uftc8inx 9288 3 for for IN cord-010092-uftc8inx 9288 4 further further JJ cord-010092-uftc8inx 9288 5 investigations investigation NNS cord-010092-uftc8inx 9288 6 , , , cord-010092-uftc8inx 9288 7 clarifications clarification NNS cord-010092-uftc8inx 9288 8 and and CC cord-010092-uftc8inx 9288 9 advice advice NN cord-010092-uftc8inx 9288 10 for for IN cord-010092-uftc8inx 9288 11 compatible compatible JJ cord-010092-uftc8inx 9288 12 transfusion transfusion NN cord-010092-uftc8inx 9288 13 in in IN cord-010092-uftc8inx 9288 14 case case NN cord-010092-uftc8inx 9288 15 of of IN cord-010092-uftc8inx 9288 16 need need NN cord-010092-uftc8inx 9288 17 . . . cord-010092-uftc8inx 9289 1 The the DT cord-010092-uftc8inx 9289 2 report report NN cord-010092-uftc8inx 9289 3 of of IN cord-010092-uftc8inx 9289 4 the the DT cord-010092-uftc8inx 9289 5 reference reference NN cord-010092-uftc8inx 9289 6 lab lab NN cord-010092-uftc8inx 9289 7 revealed reveal VBD cord-010092-uftc8inx 9289 8 the the DT cord-010092-uftc8inx 9289 9 development development NN cord-010092-uftc8inx 9289 10 of of IN cord-010092-uftc8inx 9289 11 additional additional JJ cord-010092-uftc8inx 9289 12 anti anti JJ cord-010092-uftc8inx 9289 13 - - JJ cord-010092-uftc8inx 9289 14 M m JJ cord-010092-uftc8inx 9289 15 and and CC cord-010092-uftc8inx 9289 16 anti anti NNP cord-010092-uftc8inx 9289 17 - - NNP cord-010092-uftc8inx 9289 18 S s NN cord-010092-uftc8inx 9289 19 with with IN cord-010092-uftc8inx 9289 20 confirmation confirmation NN cord-010092-uftc8inx 9289 21 of of IN cord-010092-uftc8inx 9289 22 the the DT cord-010092-uftc8inx 9289 23 presence presence NN cord-010092-uftc8inx 9289 24 of of IN cord-010092-uftc8inx 9289 25 anti anti NNP cord-010092-uftc8inx 9289 26 - - NNP cord-010092-uftc8inx 9289 27 Fya Fya NNP cord-010092-uftc8inx 9289 28 , , , cord-010092-uftc8inx 9289 29 anti anti JJ cord-010092-uftc8inx 9289 30 - - JJ cord-010092-uftc8inx 9289 31 K k JJ cord-010092-uftc8inx 9289 32 and and CC cord-010092-uftc8inx 9289 33 warm warm JJ cord-010092-uftc8inx 9289 34 auto auto NN cord-010092-uftc8inx 9289 35 - - HYPH cord-010092-uftc8inx 9289 36 antibodies antibody NNS cord-010092-uftc8inx 9289 37 . . . cord-010092-uftc8inx 9290 1 Phenotyping phenotyping NN cord-010092-uftc8inx 9290 2 of of IN cord-010092-uftc8inx 9290 3 RBCs rbc NNS cord-010092-uftc8inx 9290 4 was be VBD cord-010092-uftc8inx 9290 5 confirmed confirm VBN cord-010092-uftc8inx 9290 6 by by IN cord-010092-uftc8inx 9290 7 molecular molecular JJ cord-010092-uftc8inx 9290 8 diagnostic diagnostic JJ cord-010092-uftc8inx 9290 9 testing testing NN cord-010092-uftc8inx 9290 10 done do VBN cord-010092-uftc8inx 9290 11 in in IN cord-010092-uftc8inx 9290 12 the the DT cord-010092-uftc8inx 9290 13 reference reference NN cord-010092-uftc8inx 9290 14 lab lab NN cord-010092-uftc8inx 9290 15 ; ; : cord-010092-uftc8inx 9290 16 as as IN cord-010092-uftc8inx 9290 17 R1r R1r NNP cord-010092-uftc8inx 9290 18 , , , cord-010092-uftc8inx 9290 19 K k NN cord-010092-uftc8inx 9290 20 - - HYPH cord-010092-uftc8inx 9290 21 neg neg NNP cord-010092-uftc8inx 9290 22 . . . cord-010092-uftc8inx 9290 23 Summary Summary NNP cord-010092-uftc8inx 9290 24 / / SYM cord-010092-uftc8inx 9290 25 Conclusions Conclusions NNPS cord-010092-uftc8inx 9290 26 : : : cord-010092-uftc8inx 9291 1 Finding find VBG cord-010092-uftc8inx 9291 2 compatible compatible JJ cord-010092-uftc8inx 9291 3 blood blood NN cord-010092-uftc8inx 9291 4 may may MD cord-010092-uftc8inx 9291 5 be be VB cord-010092-uftc8inx 9291 6 extremely extremely RB cord-010092-uftc8inx 9291 7 difficult difficult JJ cord-010092-uftc8inx 9291 8 in in IN cord-010092-uftc8inx 9291 9 patients patient NNS cord-010092-uftc8inx 9291 10 with with IN cord-010092-uftc8inx 9291 11 SCD SCD NNP cord-010092-uftc8inx 9291 12 who who WP cord-010092-uftc8inx 9291 13 develop develop VBP cord-010092-uftc8inx 9291 14 multiple multiple JJ cord-010092-uftc8inx 9291 15 alloantibodies alloantibody NNS cord-010092-uftc8inx 9291 16 . . . cord-010092-uftc8inx 9292 1 It -PRON- PRP cord-010092-uftc8inx 9292 2 is be VBZ cord-010092-uftc8inx 9292 3 therefore therefore RB cord-010092-uftc8inx 9292 4 essential essential JJ cord-010092-uftc8inx 9292 5 to to TO cord-010092-uftc8inx 9292 6 perform perform VB cord-010092-uftc8inx 9292 7 an an DT cord-010092-uftc8inx 9292 8 initial initial JJ cord-010092-uftc8inx 9292 9 extended extended JJ cord-010092-uftc8inx 9292 10 red red JJ cord-010092-uftc8inx 9292 11 cell cell NN cord-010092-uftc8inx 9292 12 phenotyping phenotyping NN cord-010092-uftc8inx 9292 13 for for IN cord-010092-uftc8inx 9292 14 the the DT cord-010092-uftc8inx 9292 15 patients patient NNS cord-010092-uftc8inx 9292 16 at at IN cord-010092-uftc8inx 9292 17 diagnosis diagnosis NN cord-010092-uftc8inx 9292 18 and and CC cord-010092-uftc8inx 9292 19 to to TO cord-010092-uftc8inx 9292 20 have have VB cord-010092-uftc8inx 9292 21 on on IN cord-010092-uftc8inx 9292 22 shelf shelf NN cord-010092-uftc8inx 9292 23 ready ready JJ cord-010092-uftc8inx 9292 24 phenotyped phenotype VBD cord-010092-uftc8inx 9292 25 blood blood NN cord-010092-uftc8inx 9292 26 units unit NNS cord-010092-uftc8inx 9292 27 for for IN cord-010092-uftc8inx 9292 28 issuing issue VBG cord-010092-uftc8inx 9292 29 to to IN cord-010092-uftc8inx 9292 30 the the DT cord-010092-uftc8inx 9292 31 patients patient NNS cord-010092-uftc8inx 9292 32 , , , cord-010092-uftc8inx 9292 33 to to TO cord-010092-uftc8inx 9292 34 minimize minimize VB cord-010092-uftc8inx 9292 35 allo allo NN cord-010092-uftc8inx 9292 36 - - HYPH cord-010092-uftc8inx 9292 37 immunization immunization NN cord-010092-uftc8inx 9292 38 . . . cord-010092-uftc8inx 9293 1 Transfusion transfusion NN cord-010092-uftc8inx 9293 2 may may MD cord-010092-uftc8inx 9293 3 occasionally occasionally RB cord-010092-uftc8inx 9293 4 be be VB cord-010092-uftc8inx 9293 5 avoided avoid VBN cord-010092-uftc8inx 9293 6 in in IN cord-010092-uftc8inx 9293 7 allo allo NN cord-010092-uftc8inx 9293 8 - - HYPH cord-010092-uftc8inx 9293 9 immunized immunize VBN cord-010092-uftc8inx 9293 10 patients patient NNS cord-010092-uftc8inx 9293 11 , , , cord-010092-uftc8inx 9293 12 utilizing utilize VBG cord-010092-uftc8inx 9293 13 alternative alternative JJ cord-010092-uftc8inx 9293 14 options option NNS cord-010092-uftc8inx 9293 15 of of IN cord-010092-uftc8inx 9293 16 treatment treatment NN cord-010092-uftc8inx 9293 17 and and CC cord-010092-uftc8inx 9293 18 reducing reduce VBG cord-010092-uftc8inx 9293 19 the the DT cord-010092-uftc8inx 9293 20 risk risk NN cord-010092-uftc8inx 9293 21 of of IN cord-010092-uftc8inx 9293 22 serious serious JJ cord-010092-uftc8inx 9293 23 complications complication NNS cord-010092-uftc8inx 9293 24 such such JJ cord-010092-uftc8inx 9293 25 as as IN cord-010092-uftc8inx 9293 26 hemolytic hemolytic JJ cord-010092-uftc8inx 9293 27 transfusion transfusion NN cord-010092-uftc8inx 9293 28 reactions reaction NNS cord-010092-uftc8inx 9293 29 . . . cord-010092-uftc8inx 9294 1 Background background NN cord-010092-uftc8inx 9294 2 : : : cord-010092-uftc8inx 9295 1 Red red JJ cord-010092-uftc8inx 9295 2 blood blood NN cord-010092-uftc8inx 9295 3 cell cell NN cord-010092-uftc8inx 9295 4 ( ( -LRB- cord-010092-uftc8inx 9295 5 RBC RBC NNP cord-010092-uftc8inx 9295 6 ) ) -RRB- cord-010092-uftc8inx 9295 7 antigens antigen NNS cord-010092-uftc8inx 9295 8 that that WDT cord-010092-uftc8inx 9295 9 are be VBP cord-010092-uftc8inx 9295 10 present present JJ cord-010092-uftc8inx 9295 11 on on IN cord-010092-uftc8inx 9295 12 less less JJR cord-010092-uftc8inx 9295 13 than than IN cord-010092-uftc8inx 9295 14 1 1 CD cord-010092-uftc8inx 9295 15 % % NN cord-010092-uftc8inx 9295 16 of of IN cord-010092-uftc8inx 9295 17 most most JJS cord-010092-uftc8inx 9295 18 populations population NNS cord-010092-uftc8inx 9295 19 are be VBP cord-010092-uftc8inx 9295 20 known know VBN cord-010092-uftc8inx 9295 21 as as IN cord-010092-uftc8inx 9295 22 low low JJ cord-010092-uftc8inx 9295 23 incidence incidence NN cord-010092-uftc8inx 9295 24 antigens antigen NNS cord-010092-uftc8inx 9295 25 and and CC cord-010092-uftc8inx 9295 26 those those DT cord-010092-uftc8inx 9295 27 present present JJ cord-010092-uftc8inx 9295 28 on on IN cord-010092-uftc8inx 9295 29 more more JJR cord-010092-uftc8inx 9295 30 than than IN cord-010092-uftc8inx 9295 31 90 90 CD cord-010092-uftc8inx 9295 32 % % NN cord-010092-uftc8inx 9295 33 are be VBP cord-010092-uftc8inx 9295 34 known know VBN cord-010092-uftc8inx 9295 35 has have VBZ cord-010092-uftc8inx 9295 36 high high JJ cord-010092-uftc8inx 9295 37 incidence incidence NN cord-010092-uftc8inx 9295 38 antigens antigen NNS cord-010092-uftc8inx 9295 39 . . . cord-010092-uftc8inx 9296 1 The the DT cord-010092-uftc8inx 9296 2 MNS MNS NNP cord-010092-uftc8inx 9296 3 blood blood NN cord-010092-uftc8inx 9296 4 group group NN cord-010092-uftc8inx 9296 5 system system NN cord-010092-uftc8inx 9296 6 consists consist VBZ cord-010092-uftc8inx 9296 7 of of IN cord-010092-uftc8inx 9296 8 49 49 CD cord-010092-uftc8inx 9296 9 antigens antigen NNS cord-010092-uftc8inx 9296 10 carried carry VBN cord-010092-uftc8inx 9296 11 on on IN cord-010092-uftc8inx 9296 12 glycophorin glycophorin NNP cord-010092-uftc8inx 9296 13 A A NNP cord-010092-uftc8inx 9296 14 ( ( -LRB- cord-010092-uftc8inx 9296 15 GPA GPA NNP cord-010092-uftc8inx 9296 16 ) ) -RRB- cord-010092-uftc8inx 9296 17 , , , cord-010092-uftc8inx 9296 18 glycophorin glycophorin NNP cord-010092-uftc8inx 9296 19 B B NNP cord-010092-uftc8inx 9296 20 ( ( -LRB- cord-010092-uftc8inx 9296 21 GPB GPB NNP cord-010092-uftc8inx 9296 22 ) ) -RRB- cord-010092-uftc8inx 9296 23 or or CC cord-010092-uftc8inx 9296 24 on on IN cord-010092-uftc8inx 9296 25 hybrids hybrid NNS cord-010092-uftc8inx 9296 26 of of IN cord-010092-uftc8inx 9296 27 these these DT cord-010092-uftc8inx 9296 28 glycophorins glycophorin NNS cord-010092-uftc8inx 9296 29 . . . cord-010092-uftc8inx 9297 1 There there EX cord-010092-uftc8inx 9297 2 are be VBP cord-010092-uftc8inx 9297 3 35 35 CD cord-010092-uftc8inx 9297 4 low low JJ cord-010092-uftc8inx 9297 5 incidence incidence NN cord-010092-uftc8inx 9297 6 and and CC cord-010092-uftc8inx 9297 7 10 10 CD cord-010092-uftc8inx 9297 8 high high JJ cord-010092-uftc8inx 9297 9 incidence incidence NN cord-010092-uftc8inx 9297 10 antigens antigen NNS cord-010092-uftc8inx 9297 11 in in IN cord-010092-uftc8inx 9297 12 the the DT cord-010092-uftc8inx 9297 13 MNS MNS NNP cord-010092-uftc8inx 9297 14 blood blood NN cord-010092-uftc8inx 9297 15 group group NN cord-010092-uftc8inx 9297 16 system system NN cord-010092-uftc8inx 9297 17 . . . cord-010092-uftc8inx 9298 1 An an DT cord-010092-uftc8inx 9298 2 individual individual NN cord-010092-uftc8inx 9298 3 that that WDT cord-010092-uftc8inx 9298 4 is be VBZ cord-010092-uftc8inx 9298 5 homozygous homozygous JJ cord-010092-uftc8inx 9298 6 for for IN cord-010092-uftc8inx 9298 7 GP.Mur GP.Mur NNP cord-010092-uftc8inx 9298 8 will will MD cord-010092-uftc8inx 9298 9 be be VB cord-010092-uftc8inx 9298 10 negative negative JJ cord-010092-uftc8inx 9298 11 for for IN cord-010092-uftc8inx 9298 12 the the DT cord-010092-uftc8inx 9298 13 high high JJ cord-010092-uftc8inx 9298 14 incidence incidence NN cord-010092-uftc8inx 9298 15 JENU JENU NNP cord-010092-uftc8inx 9298 16 ( ( -LRB- cord-010092-uftc8inx 9298 17 MNS49 MNS49 NNP cord-010092-uftc8inx 9298 18 ) ) -RRB- cord-010092-uftc8inx 9298 19 antigen antigen NNP cord-010092-uftc8inx 9298 20 . . . cord-010092-uftc8inx 9299 1 Anti Anti NNP cord-010092-uftc8inx 9299 2 - - NNP cord-010092-uftc8inx 9299 3 JENU JENU NNP cord-010092-uftc8inx 9299 4 was be VBD cord-010092-uftc8inx 9299 5 first first RB cord-010092-uftc8inx 9299 6 described describe VBN cord-010092-uftc8inx 9299 7 in in IN cord-010092-uftc8inx 9299 8 a a DT cord-010092-uftc8inx 9299 9 Thai thai JJ cord-010092-uftc8inx 9299 10 patient patient NN cord-010092-uftc8inx 9299 11 with with IN cord-010092-uftc8inx 9299 12 thalassemia thalassemia NN cord-010092-uftc8inx 9299 13 where where WRB cord-010092-uftc8inx 9299 14 only only RB cord-010092-uftc8inx 9299 15 2 2 CD cord-010092-uftc8inx 9299 16 compatible compatible JJ cord-010092-uftc8inx 9299 17 units unit NNS cord-010092-uftc8inx 9299 18 were be VBD cord-010092-uftc8inx 9299 19 found find VBN cord-010092-uftc8inx 9299 20 following follow VBG cord-010092-uftc8inx 9299 21 screening screening NN cord-010092-uftc8inx 9299 22 of of IN cord-010092-uftc8inx 9299 23 3600 3600 CD cord-010092-uftc8inx 9299 24 units unit NNS cord-010092-uftc8inx 9299 25 . . . cord-010092-uftc8inx 9300 1 The the DT cord-010092-uftc8inx 9300 2 JENU JENU NNP cord-010092-uftc8inx 9300 3 negative negative JJ cord-010092-uftc8inx 9300 4 phenotype phenotype NN cord-010092-uftc8inx 9300 5 is be VBZ cord-010092-uftc8inx 9300 6 a a DT cord-010092-uftc8inx 9300 7 rare rare JJ cord-010092-uftc8inx 9300 8 phenotype phenotype NN cord-010092-uftc8inx 9300 9 with with IN cord-010092-uftc8inx 9300 10 an an DT cord-010092-uftc8inx 9300 11 estimated estimate VBN cord-010092-uftc8inx 9300 12 frequency frequency NN cord-010092-uftc8inx 9300 13 of of IN cord-010092-uftc8inx 9300 14 0.06 0.06 CD cord-010092-uftc8inx 9300 15 % % NN cord-010092-uftc8inx 9300 16 . . . cord-010092-uftc8inx 9301 1 A a DT cord-010092-uftc8inx 9301 2 male male JJ cord-010092-uftc8inx 9301 3 patient patient NN cord-010092-uftc8inx 9301 4 with with IN cord-010092-uftc8inx 9301 5 a a DT cord-010092-uftc8inx 9301 6 history history NN cord-010092-uftc8inx 9301 7 of of IN cord-010092-uftc8inx 9301 8 previous previous JJ cord-010092-uftc8inx 9301 9 transfusion transfusion NN cord-010092-uftc8inx 9301 10 presented present VBN cord-010092-uftc8inx 9301 11 with with IN cord-010092-uftc8inx 9301 12 an an DT cord-010092-uftc8inx 9301 13 anti anti JJ cord-010092-uftc8inx 9301 14 - - JJ cord-010092-uftc8inx 9301 15 E E NNS cord-010092-uftc8inx 9301 16 and and CC cord-010092-uftc8inx 9301 17 a a DT cord-010092-uftc8inx 9301 18 weak weak JJ cord-010092-uftc8inx 9301 19 auto auto NN cord-010092-uftc8inx 9301 20 antibody antibody NN cord-010092-uftc8inx 9301 21 with with IN cord-010092-uftc8inx 9301 22 no no DT cord-010092-uftc8inx 9301 23 apparent apparent JJ cord-010092-uftc8inx 9301 24 specificity specificity NN cord-010092-uftc8inx 9301 25 . . . cord-010092-uftc8inx 9302 1 A a DT cord-010092-uftc8inx 9302 2 donor donor NN cord-010092-uftc8inx 9302 3 unit unit NN cord-010092-uftc8inx 9302 4 selected select VBN cord-010092-uftc8inx 9302 5 for for IN cord-010092-uftc8inx 9302 6 cross cross NN cord-010092-uftc8inx 9302 7 match match NN cord-010092-uftc8inx 9302 8 ( ( -LRB- cord-010092-uftc8inx 9302 9 group group NN cord-010092-uftc8inx 9302 10 O o UH cord-010092-uftc8inx 9302 11 RhD rhd NN cord-010092-uftc8inx 9302 12 positive positive JJ cord-010092-uftc8inx 9302 13 , , , cord-010092-uftc8inx 9302 14 C+E C+E NNP cord-010092-uftc8inx 9302 15 - - HYPH cord-010092-uftc8inx 9302 16 c c NNP cord-010092-uftc8inx 9302 17 - - : cord-010092-uftc8inx 9302 18 e+ e+ NNP cord-010092-uftc8inx 9302 19 , , , cord-010092-uftc8inx 9302 20 K- K- NNP cord-010092-uftc8inx 9302 21 ) ) -RRB- cord-010092-uftc8inx 9302 22 was be VBD cord-010092-uftc8inx 9302 23 incompatible incompatible JJ cord-010092-uftc8inx 9302 24 with with IN cord-010092-uftc8inx 9302 25 a a DT cord-010092-uftc8inx 9302 26 reaction reaction NN cord-010092-uftc8inx 9302 27 grade grade NN cord-010092-uftc8inx 9302 28 of of IN cord-010092-uftc8inx 9302 29 4 4 CD cord-010092-uftc8inx 9302 30 + + NN cord-010092-uftc8inx 9302 31 by by IN cord-010092-uftc8inx 9302 32 column column NN cord-010092-uftc8inx 9302 33 agglutination agglutination NN cord-010092-uftc8inx 9302 34 technology technology NN cord-010092-uftc8inx 9302 35 . . . cord-010092-uftc8inx 9303 1 The the DT cord-010092-uftc8inx 9303 2 patient patient NN cord-010092-uftc8inx 9303 3 's 's POS cord-010092-uftc8inx 9303 4 sample sample NN cord-010092-uftc8inx 9303 5 and and CC cord-010092-uftc8inx 9303 6 donor donor NN cord-010092-uftc8inx 9303 7 unit unit NN cord-010092-uftc8inx 9303 8 were be VBD cord-010092-uftc8inx 9303 9 referred refer VBN cord-010092-uftc8inx 9303 10 to to IN cord-010092-uftc8inx 9303 11 the the DT cord-010092-uftc8inx 9303 12 Red Red NNP cord-010092-uftc8inx 9303 13 Cell Cell NNP cord-010092-uftc8inx 9303 14 Reference Reference NNP cord-010092-uftc8inx 9303 15 Laboratory Laboratory NNP cord-010092-uftc8inx 9303 16 for for IN cord-010092-uftc8inx 9303 17 investigation investigation NN cord-010092-uftc8inx 9303 18 for for IN cord-010092-uftc8inx 9303 19 a a DT cord-010092-uftc8inx 9303 20 possible possible JJ cord-010092-uftc8inx 9303 21 antibody antibody NN cord-010092-uftc8inx 9303 22 to to IN cord-010092-uftc8inx 9303 23 a a DT cord-010092-uftc8inx 9303 24 low low JJ cord-010092-uftc8inx 9303 25 incidence incidence NN cord-010092-uftc8inx 9303 26 antigen antigen NN cord-010092-uftc8inx 9303 27 . . . cord-010092-uftc8inx 9304 1 Aims aim VBZ cord-010092-uftc8inx 9304 2 : : : cord-010092-uftc8inx 9305 1 We -PRON- PRP cord-010092-uftc8inx 9305 2 aim aim VBP cord-010092-uftc8inx 9305 3 to to TO cord-010092-uftc8inx 9305 4 characterize characterize VB cord-010092-uftc8inx 9305 5 the the DT cord-010092-uftc8inx 9305 6 phenotype phenotype NN cord-010092-uftc8inx 9305 7 of of IN cord-010092-uftc8inx 9305 8 the the DT cord-010092-uftc8inx 9305 9 incompatible incompatible JJ cord-010092-uftc8inx 9305 10 donor donor NN cord-010092-uftc8inx 9305 11 unit unit NN cord-010092-uftc8inx 9305 12 . . . cord-010092-uftc8inx 9306 1 Methods method NNS cord-010092-uftc8inx 9306 2 : : : cord-010092-uftc8inx 9307 1 Standard standard JJ cord-010092-uftc8inx 9307 2 serological serological JJ cord-010092-uftc8inx 9307 3 procedures procedure NNS cord-010092-uftc8inx 9307 4 were be VBD cord-010092-uftc8inx 9307 5 used use VBN cord-010092-uftc8inx 9307 6 to to TO cord-010092-uftc8inx 9307 7 identify identify VB cord-010092-uftc8inx 9307 8 the the DT cord-010092-uftc8inx 9307 9 antibody antibody NN cord-010092-uftc8inx 9307 10 specificities specificity NNS cord-010092-uftc8inx 9307 11 in in IN cord-010092-uftc8inx 9307 12 the the DT cord-010092-uftc8inx 9307 13 patient patient NN cord-010092-uftc8inx 9307 14 's 's POS cord-010092-uftc8inx 9307 15 sample sample NN cord-010092-uftc8inx 9307 16 . . . cord-010092-uftc8inx 9308 1 Blood blood NN cord-010092-uftc8inx 9308 2 group group NN cord-010092-uftc8inx 9308 3 phenotyping phenotyping NN cord-010092-uftc8inx 9308 4 of of IN cord-010092-uftc8inx 9308 5 the the DT cord-010092-uftc8inx 9308 6 patient patient NN cord-010092-uftc8inx 9308 7 and and CC cord-010092-uftc8inx 9308 8 donor donor NN cord-010092-uftc8inx 9308 9 was be VBD cord-010092-uftc8inx 9308 10 performed perform VBN cord-010092-uftc8inx 9308 11 by by IN cord-010092-uftc8inx 9308 12 standard standard JJ cord-010092-uftc8inx 9308 13 serological serological JJ cord-010092-uftc8inx 9308 14 procedures procedure NNS cord-010092-uftc8inx 9308 15 . . . cord-010092-uftc8inx 9309 1 Genotyping genotyping NN cord-010092-uftc8inx 9309 2 and and CC cord-010092-uftc8inx 9309 3 zygosity zygosity NN cord-010092-uftc8inx 9309 4 testing testing NN cord-010092-uftc8inx 9309 5 was be VBD cord-010092-uftc8inx 9309 6 performed perform VBN cord-010092-uftc8inx 9309 7 using use VBG cord-010092-uftc8inx 9309 8 polymerase polymerase NN cord-010092-uftc8inx 9309 9 chain chain NN cord-010092-uftc8inx 9309 10 reaction reaction NN cord-010092-uftc8inx 9309 11 ( ( -LRB- cord-010092-uftc8inx 9309 12 PCR PCR NNP cord-010092-uftc8inx 9309 13 ) ) -RRB- cord-010092-uftc8inx 9309 14 high high JJ cord-010092-uftc8inx 9309 15 - - HYPH cord-010092-uftc8inx 9309 16 resolution resolution NN cord-010092-uftc8inx 9309 17 melting melting NN cord-010092-uftc8inx 9309 18 ( ( -LRB- cord-010092-uftc8inx 9309 19 HRM HRM NNP cord-010092-uftc8inx 9309 20 ) ) -RRB- cord-010092-uftc8inx 9309 21 assay assay NN cord-010092-uftc8inx 9309 22 . . . cord-010092-uftc8inx 9310 1 GP.Mur GP.Mur NNP cord-010092-uftc8inx 9310 2 is be VBZ cord-010092-uftc8inx 9310 3 a a DT cord-010092-uftc8inx 9310 4 GP(B gp(b NN cord-010092-uftc8inx 9310 5 - - HYPH cord-010092-uftc8inx 9310 6 A a NN cord-010092-uftc8inx 9310 7 - - HYPH cord-010092-uftc8inx 9310 8 B b NN cord-010092-uftc8inx 9310 9 ) ) -RRB- cord-010092-uftc8inx 9310 10 hybrid hybrid JJ cord-010092-uftc8inx 9310 11 glycophorin glycophorin NN cord-010092-uftc8inx 9310 12 resulting result VBG cord-010092-uftc8inx 9310 13 from from IN cord-010092-uftc8inx 9310 14 a a DT cord-010092-uftc8inx 9310 15 gene gene NN cord-010092-uftc8inx 9310 16 conversion conversion NN cord-010092-uftc8inx 9310 17 event event NN cord-010092-uftc8inx 9310 18 between between IN cord-010092-uftc8inx 9310 19 GYPA GYPA NNP cord-010092-uftc8inx 9310 20 and and CC cord-010092-uftc8inx 9310 21 GYPB GYPB NNP cord-010092-uftc8inx 9310 22 . . . cord-010092-uftc8inx 9311 1 This this DT cord-010092-uftc8inx 9311 2 disruption disruption NN cord-010092-uftc8inx 9311 3 to to IN cord-010092-uftc8inx 9311 4 GPB GPB NNP cord-010092-uftc8inx 9311 5 impacts impact VBZ cord-010092-uftc8inx 9311 6 s s POS cord-010092-uftc8inx 9311 7 expression expression NN cord-010092-uftc8inx 9311 8 . . . cord-010092-uftc8inx 9312 1 The the DT cord-010092-uftc8inx 9312 2 donor donor NN cord-010092-uftc8inx 9312 3 was be VBD cord-010092-uftc8inx 9312 4 negative negative JJ cord-010092-uftc8inx 9312 5 with with IN cord-010092-uftc8inx 9312 6 anti anti JJ cord-010092-uftc8inx 9312 7 - - JJ cord-010092-uftc8inx 9312 8 S s JJ cord-010092-uftc8inx 9312 9 MoAb MoAb NNP cord-010092-uftc8inx 9312 10 ( ( -LRB- cord-010092-uftc8inx 9312 11 Albaclone Albaclone NNP cord-010092-uftc8inx 9312 12 ) ) -RRB- cord-010092-uftc8inx 9312 13 , , , cord-010092-uftc8inx 9312 14 positive positive JJ cord-010092-uftc8inx 9312 15 with with IN cord-010092-uftc8inx 9312 16 anti anti JJ cord-010092-uftc8inx 9312 17 - - JJ cord-010092-uftc8inx 9312 18 s s JJ cord-010092-uftc8inx 9312 19 polyclonal polyclonal JJ cord-010092-uftc8inx 9312 20 ( ( -LRB- cord-010092-uftc8inx 9312 21 Immulab Immulab NNP cord-010092-uftc8inx 9312 22 ) ) -RRB- cord-010092-uftc8inx 9312 23 and and CC cord-010092-uftc8inx 9312 24 negative negative JJ cord-010092-uftc8inx 9312 25 with with IN cord-010092-uftc8inx 9312 26 anti anti JJ cord-010092-uftc8inx 9312 27 - - JJ cord-010092-uftc8inx 9312 28 s s JJ cord-010092-uftc8inx 9312 29 monoclonal monoclonal JJ cord-010092-uftc8inx 9312 30 antibody antibody NN cord-010092-uftc8inx 9312 31 ( ( -LRB- cord-010092-uftc8inx 9312 32 Immulab Immulab NNP cord-010092-uftc8inx 9312 33 ) ) -RRB- cord-010092-uftc8inx 9312 34 . . . cord-010092-uftc8inx 9313 1 This this DT cord-010092-uftc8inx 9313 2 S S NNP cord-010092-uftc8inx 9313 3 and and CC cord-010092-uftc8inx 9313 4 s s POS cord-010092-uftc8inx 9313 5 phenotype phenotype NN cord-010092-uftc8inx 9313 6 was be VBD cord-010092-uftc8inx 9313 7 consistent consistent JJ cord-010092-uftc8inx 9313 8 with with IN cord-010092-uftc8inx 9313 9 the the DT cord-010092-uftc8inx 9313 10 previously previously RB cord-010092-uftc8inx 9313 11 reported report VBN cord-010092-uftc8inx 9313 12 examples example NNS cord-010092-uftc8inx 9313 13 of of IN cord-010092-uftc8inx 9313 14 GP.Mur GP.Mur NNP cord-010092-uftc8inx 9313 15 homozygote homozygote NNP cord-010092-uftc8inx 9313 16 JENU JENU NNP cord-010092-uftc8inx 9313 17 negative negative JJ cord-010092-uftc8inx 9313 18 individuals individual NNS cord-010092-uftc8inx 9313 19 . . . cord-010092-uftc8inx 9314 1 Molecular molecular JJ cord-010092-uftc8inx 9314 2 testing testing NN cord-010092-uftc8inx 9314 3 was be VBD cord-010092-uftc8inx 9314 4 consistent consistent JJ cord-010092-uftc8inx 9314 5 with with IN cord-010092-uftc8inx 9314 6 serology serology NN cord-010092-uftc8inx 9314 7 supporting support VBG cord-010092-uftc8inx 9314 8 GP.Mur GP.Mur NNP cord-010092-uftc8inx 9314 9 homozygosity homozygosity NN cord-010092-uftc8inx 9314 10 and and CC cord-010092-uftc8inx 9314 11 JENU JENU NNP cord-010092-uftc8inx 9314 12 negative negative JJ cord-010092-uftc8inx 9314 13 phenotype phenotype NN cord-010092-uftc8inx 9314 14 . . . cord-010092-uftc8inx 9315 1 Summary Summary NNP cord-010092-uftc8inx 9315 2 / / SYM cord-010092-uftc8inx 9315 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 9315 4 : : : cord-010092-uftc8inx 9316 1 This this DT cord-010092-uftc8inx 9316 2 donor donor NN cord-010092-uftc8inx 9316 3 has have VBZ cord-010092-uftc8inx 9316 4 been be VBN cord-010092-uftc8inx 9316 5 added add VBN cord-010092-uftc8inx 9316 6 to to IN cord-010092-uftc8inx 9316 7 our -PRON- PRP$ cord-010092-uftc8inx 9316 8 rare rare JJ cord-010092-uftc8inx 9316 9 donor donor NN cord-010092-uftc8inx 9316 10 panel panel NN cord-010092-uftc8inx 9316 11 and and CC cord-010092-uftc8inx 9316 12 their -PRON- PRP$ cord-010092-uftc8inx 9316 13 red red JJ cord-010092-uftc8inx 9316 14 cell cell NN cord-010092-uftc8inx 9316 15 donations donation NNS cord-010092-uftc8inx 9316 16 are be VBP cord-010092-uftc8inx 9316 17 cryopreserved cryopreserve VBN cord-010092-uftc8inx 9316 18 for for IN cord-010092-uftc8inx 9316 19 future future JJ cord-010092-uftc8inx 9316 20 use use NN cord-010092-uftc8inx 9316 21 in in IN cord-010092-uftc8inx 9316 22 our -PRON- PRP$ cord-010092-uftc8inx 9316 23 rare rare JJ cord-010092-uftc8inx 9316 24 donor donor NN cord-010092-uftc8inx 9316 25 frozen freeze VBN cord-010092-uftc8inx 9316 26 inventory inventory NN cord-010092-uftc8inx 9316 27 . . . cord-010092-uftc8inx 9317 1 There there EX cord-010092-uftc8inx 9317 2 is be VBZ cord-010092-uftc8inx 9317 3 limited limited JJ cord-010092-uftc8inx 9317 4 anti anti JJ cord-010092-uftc8inx 9317 5 - - JJ cord-010092-uftc8inx 9317 6 JENU jenu JJ cord-010092-uftc8inx 9317 7 antiserum antiserum NN cord-010092-uftc8inx 9317 8 available available JJ cord-010092-uftc8inx 9317 9 to to TO cord-010092-uftc8inx 9317 10 confirm confirm VB cord-010092-uftc8inx 9317 11 the the DT cord-010092-uftc8inx 9317 12 JENU JENU NNP cord-010092-uftc8inx 9317 13 negative negative JJ cord-010092-uftc8inx 9317 14 phenotype phenotype NN cord-010092-uftc8inx 9317 15 . . . cord-010092-uftc8inx 9318 1 We -PRON- PRP cord-010092-uftc8inx 9318 2 currently currently RB cord-010092-uftc8inx 9318 3 rely rely VBP cord-010092-uftc8inx 9318 4 on on IN cord-010092-uftc8inx 9318 5 the the DT cord-010092-uftc8inx 9318 6 serological serological JJ cord-010092-uftc8inx 9318 7 profile profile NN cord-010092-uftc8inx 9318 8 of of IN cord-010092-uftc8inx 9318 9 red red JJ cord-010092-uftc8inx 9318 10 cells cell NNS cord-010092-uftc8inx 9318 11 presenting present VBG cord-010092-uftc8inx 9318 12 with with IN cord-010092-uftc8inx 9318 13 the the DT cord-010092-uftc8inx 9318 14 GP.Mur GP.Mur NNP cord-010092-uftc8inx 9318 15 phenotype phenotype NN cord-010092-uftc8inx 9318 16 , , , cord-010092-uftc8inx 9318 17 S S NNP cord-010092-uftc8inx 9318 18 negative negative JJ cord-010092-uftc8inx 9318 19 and and CC cord-010092-uftc8inx 9318 20 the the DT cord-010092-uftc8inx 9318 21 discrepant discrepant JJ cord-010092-uftc8inx 9318 22 s s NN cord-010092-uftc8inx 9318 23 phenotyping phenotyping NN cord-010092-uftc8inx 9318 24 to to TO cord-010092-uftc8inx 9318 25 identify identify VB cord-010092-uftc8inx 9318 26 JENU JENU NNP cord-010092-uftc8inx 9318 27 negative negative JJ cord-010092-uftc8inx 9318 28 donors donor NNS cord-010092-uftc8inx 9318 29 . . . cord-010092-uftc8inx 9319 1 This this DT cord-010092-uftc8inx 9319 2 case case NN cord-010092-uftc8inx 9319 3 has have VBZ cord-010092-uftc8inx 9319 4 highlighted highlight VBN cord-010092-uftc8inx 9319 5 the the DT cord-010092-uftc8inx 9319 6 importance importance NN cord-010092-uftc8inx 9319 7 of of IN cord-010092-uftc8inx 9319 8 following follow VBG cord-010092-uftc8inx 9319 9 up up RP cord-010092-uftc8inx 9319 10 unexplained unexplained JJ cord-010092-uftc8inx 9319 11 serological serological JJ cord-010092-uftc8inx 9319 12 incompatibilities incompatibility NNS cord-010092-uftc8inx 9319 13 . . . cord-010092-uftc8inx 9320 1 The the DT cord-010092-uftc8inx 9320 2 development development NN cord-010092-uftc8inx 9320 3 of of IN cord-010092-uftc8inx 9320 4 a a DT cord-010092-uftc8inx 9320 5 monoclonal monoclonal JJ cord-010092-uftc8inx 9320 6 antibody antibody NN cord-010092-uftc8inx 9320 7 directed direct VBN cord-010092-uftc8inx 9320 8 against against IN cord-010092-uftc8inx 9320 9 JENU JENU NNP cord-010092-uftc8inx 9320 10 antigen antigen NN cord-010092-uftc8inx 9320 11 would would MD cord-010092-uftc8inx 9320 12 provide provide VB cord-010092-uftc8inx 9320 13 an an DT cord-010092-uftc8inx 9320 14 opportunity opportunity NN cord-010092-uftc8inx 9320 15 to to TO cord-010092-uftc8inx 9320 16 screen screen VB cord-010092-uftc8inx 9320 17 for for IN cord-010092-uftc8inx 9320 18 suitable suitable JJ cord-010092-uftc8inx 9320 19 donors donor NNS cord-010092-uftc8inx 9320 20 for for IN cord-010092-uftc8inx 9320 21 this this DT cord-010092-uftc8inx 9320 22 rare rare JJ cord-010092-uftc8inx 9320 23 phenotype phenotype NN cord-010092-uftc8inx 9320 24 . . . cord-010092-uftc8inx 9321 1 Background background NN cord-010092-uftc8inx 9321 2 : : : cord-010092-uftc8inx 9322 1 Molecules molecule NNS cord-010092-uftc8inx 9322 2 expressed express VBD cord-010092-uftc8inx 9322 3 on on IN cord-010092-uftc8inx 9322 4 tumor tumor NN cord-010092-uftc8inx 9322 5 cells cell NNS cord-010092-uftc8inx 9322 6 are be VBP cord-010092-uftc8inx 9322 7 a a DT cord-010092-uftc8inx 9322 8 target target NN cord-010092-uftc8inx 9322 9 of of IN cord-010092-uftc8inx 9322 10 interest interest NN cord-010092-uftc8inx 9322 11 for for IN cord-010092-uftc8inx 9322 12 drug drug NN cord-010092-uftc8inx 9322 13 development development NN cord-010092-uftc8inx 9322 14 by by IN cord-010092-uftc8inx 9322 15 the the DT cord-010092-uftc8inx 9322 16 use use NN cord-010092-uftc8inx 9322 17 of of IN cord-010092-uftc8inx 9322 18 monoclonal monoclonal JJ cord-010092-uftc8inx 9322 19 antibodies antibody NNS cord-010092-uftc8inx 9322 20 or or CC cord-010092-uftc8inx 9322 21 blocking block VBG cord-010092-uftc8inx 9322 22 proteins protein NNS cord-010092-uftc8inx 9322 23 . . . cord-010092-uftc8inx 9323 1 However however RB cord-010092-uftc8inx 9323 2 these these DT cord-010092-uftc8inx 9323 3 drugs drug NNS cord-010092-uftc8inx 9323 4 have have VBP cord-010092-uftc8inx 9323 5 the the DT cord-010092-uftc8inx 9323 6 potential potential NN cord-010092-uftc8inx 9323 7 to to TO cord-010092-uftc8inx 9323 8 interfere interfere VB cord-010092-uftc8inx 9323 9 in in IN cord-010092-uftc8inx 9323 10 pretransfusion pretransfusion NN cord-010092-uftc8inx 9323 11 testing testing NN cord-010092-uftc8inx 9323 12 when when WRB cord-010092-uftc8inx 9323 13 the the DT cord-010092-uftc8inx 9323 14 target target NN cord-010092-uftc8inx 9323 15 molecule molecule NN cord-010092-uftc8inx 9323 16 such such JJ cord-010092-uftc8inx 9323 17 as as IN cord-010092-uftc8inx 9323 18 CD47 CD47 NNP cord-010092-uftc8inx 9323 19 is be VBZ cord-010092-uftc8inx 9323 20 also also RB cord-010092-uftc8inx 9323 21 expressed express VBN cord-010092-uftc8inx 9323 22 on on IN cord-010092-uftc8inx 9323 23 red red JJ cord-010092-uftc8inx 9323 24 blood blood NN cord-010092-uftc8inx 9323 25 cells cell NNS cord-010092-uftc8inx 9323 26 ( ( -LRB- cord-010092-uftc8inx 9323 27 RBCs rbc NNS cord-010092-uftc8inx 9323 28 ) ) -RRB- cord-010092-uftc8inx 9323 29 . . . cord-010092-uftc8inx 9324 1 Recently recently RB cord-010092-uftc8inx 9324 2 , , , cord-010092-uftc8inx 9324 3 many many JJ cord-010092-uftc8inx 9324 4 drugs drug NNS cord-010092-uftc8inx 9324 5 targeting target VBG cord-010092-uftc8inx 9324 6 CD47 CD47 NNP cord-010092-uftc8inx 9324 7 have have VBP cord-010092-uftc8inx 9324 8 been be VBN cord-010092-uftc8inx 9324 9 developed develop VBN cord-010092-uftc8inx 9324 10 but but CC cord-010092-uftc8inx 9324 11 appropriate appropriate JJ cord-010092-uftc8inx 9324 12 mitigation mitigation NN cord-010092-uftc8inx 9324 13 strategies strategy NNS cord-010092-uftc8inx 9324 14 and and CC cord-010092-uftc8inx 9324 15 approach approach NN cord-010092-uftc8inx 9324 16 to to IN cord-010092-uftc8inx 9324 17 selecting select VBG cord-010092-uftc8inx 9324 18 RBCs rbc NNS cord-010092-uftc8inx 9324 19 for for IN cord-010092-uftc8inx 9324 20 safe safe JJ cord-010092-uftc8inx 9324 21 transfusion transfusion NN cord-010092-uftc8inx 9324 22 is be VBZ cord-010092-uftc8inx 9324 23 still still RB cord-010092-uftc8inx 9324 24 an an DT cord-010092-uftc8inx 9324 25 obstacle obstacle NN cord-010092-uftc8inx 9324 26 . . . cord-010092-uftc8inx 9325 1 Aims aim VBZ cord-010092-uftc8inx 9325 2 : : : cord-010092-uftc8inx 9325 3 We -PRON- PRP cord-010092-uftc8inx 9325 4 describe describe VBP cord-010092-uftc8inx 9325 5 a a DT cord-010092-uftc8inx 9325 6 case case NN cord-010092-uftc8inx 9325 7 of of IN cord-010092-uftc8inx 9325 8 delayed delayed JJ cord-010092-uftc8inx 9325 9 hemolytic hemolytic JJ cord-010092-uftc8inx 9325 10 transfusion transfusion NN cord-010092-uftc8inx 9325 11 reaction reaction NN cord-010092-uftc8inx 9325 12 ( ( -LRB- cord-010092-uftc8inx 9325 13 DHTR DHTR NNP cord-010092-uftc8inx 9325 14 ) ) -RRB- cord-010092-uftc8inx 9325 15 by by IN cord-010092-uftc8inx 9325 16 anti anti JJ cord-010092-uftc8inx 9325 17 - - NN cord-010092-uftc8inx 9325 18 Jk Jk NNP cord-010092-uftc8inx 9326 1 a a DT cord-010092-uftc8inx 9326 2 in in IN cord-010092-uftc8inx 9326 3 a a DT cord-010092-uftc8inx 9326 4 patient patient NN cord-010092-uftc8inx 9326 5 treated treat VBN cord-010092-uftc8inx 9326 6 previously previously RB cord-010092-uftc8inx 9326 7 with with IN cord-010092-uftc8inx 9326 8 CD47 CD47 NNP cord-010092-uftc8inx 9326 9 targeted target VBD cord-010092-uftc8inx 9326 10 high high JJ cord-010092-uftc8inx 9326 11 affinity affinity NN cord-010092-uftc8inx 9326 12 SIRPa SIRPa NNS cord-010092-uftc8inx 9326 13 fusion fusion NN cord-010092-uftc8inx 9326 14 protein protein NN cord-010092-uftc8inx 9326 15 ALX148 ALX148 NNP cord-010092-uftc8inx 9326 16 . . . cord-010092-uftc8inx 9327 1 Methods method NNS cord-010092-uftc8inx 9327 2 : : : cord-010092-uftc8inx 9328 1 A a DT cord-010092-uftc8inx 9328 2 35-year 35-year JJ cord-010092-uftc8inx 9328 3 - - HYPH cord-010092-uftc8inx 9328 4 old old JJ cord-010092-uftc8inx 9328 5 woman woman NN cord-010092-uftc8inx 9328 6 diagnosed diagnose VBN cord-010092-uftc8inx 9328 7 with with IN cord-010092-uftc8inx 9328 8 nasal nasal NN cord-010092-uftc8inx 9328 9 cavity cavity NN cord-010092-uftc8inx 9328 10 squamous squamous JJ cord-010092-uftc8inx 9328 11 cell cell NN cord-010092-uftc8inx 9328 12 carcinoma carcinoma NN cord-010092-uftc8inx 9328 13 was be VBD cord-010092-uftc8inx 9328 14 enrolled enrol VBN cord-010092-uftc8inx 9328 15 in in IN cord-010092-uftc8inx 9328 16 an an DT cord-010092-uftc8inx 9328 17 ALX148 ALX148 NNP cord-010092-uftc8inx 9328 18 clinical clinical JJ cord-010092-uftc8inx 9328 19 trial trial NN cord-010092-uftc8inx 9328 20 . . . cord-010092-uftc8inx 9329 1 Her -PRON- PRP$ cord-010092-uftc8inx 9329 2 blood blood NN cord-010092-uftc8inx 9329 3 type type NN cord-010092-uftc8inx 9329 4 was be VBD cord-010092-uftc8inx 9329 5 group group NN cord-010092-uftc8inx 9329 6 AB AB NNP cord-010092-uftc8inx 9329 7 , , , cord-010092-uftc8inx 9329 8 RhD rhd NN cord-010092-uftc8inx 9329 9 positive positive JJ cord-010092-uftc8inx 9329 10 , , , cord-010092-uftc8inx 9329 11 and and CC cord-010092-uftc8inx 9329 12 the the DT cord-010092-uftc8inx 9329 13 antibody antibody NN cord-010092-uftc8inx 9329 14 screening screening NN cord-010092-uftc8inx 9329 15 test test NN cord-010092-uftc8inx 9329 16 was be VBD cord-010092-uftc8inx 9329 17 negative negative JJ cord-010092-uftc8inx 9329 18 for for IN cord-010092-uftc8inx 9329 19 the the DT cord-010092-uftc8inx 9329 20 past past JJ cord-010092-uftc8inx 9329 21 8 8 CD cord-010092-uftc8inx 9329 22 months month NNS cord-010092-uftc8inx 9329 23 . . . cord-010092-uftc8inx 9330 1 She -PRON- PRP cord-010092-uftc8inx 9330 2 had have VBD cord-010092-uftc8inx 9330 3 no no DT cord-010092-uftc8inx 9330 4 previous previous JJ cord-010092-uftc8inx 9330 5 transfusion transfusion NN cord-010092-uftc8inx 9330 6 history history NN cord-010092-uftc8inx 9330 7 during during IN cord-010092-uftc8inx 9330 8 the the DT cord-010092-uftc8inx 9330 9 past past JJ cord-010092-uftc8inx 9330 10 two two CD cord-010092-uftc8inx 9330 11 years year NNS cord-010092-uftc8inx 9330 12 . . . cord-010092-uftc8inx 9331 1 After after IN cord-010092-uftc8inx 9331 2 two two CD cord-010092-uftc8inx 9331 3 infusions infusion NNS cord-010092-uftc8inx 9331 4 of of IN cord-010092-uftc8inx 9331 5 ALX148 alx148 NN cord-010092-uftc8inx 9331 6 , , , cord-010092-uftc8inx 9331 7 two two CD cord-010092-uftc8inx 9331 8 units unit NNS cord-010092-uftc8inx 9331 9 of of IN cord-010092-uftc8inx 9331 10 apheresis apheresis NN cord-010092-uftc8inx 9331 11 platelets platelet NNS cord-010092-uftc8inx 9331 12 were be VBD cord-010092-uftc8inx 9331 13 requested request VBN cord-010092-uftc8inx 9331 14 for for IN cord-010092-uftc8inx 9331 15 transfusion transfusion NN cord-010092-uftc8inx 9331 16 . . . cord-010092-uftc8inx 9332 1 The the DT cord-010092-uftc8inx 9332 2 blood blood NN cord-010092-uftc8inx 9332 3 bank bank NN cord-010092-uftc8inx 9332 4 noticed notice VBD cord-010092-uftc8inx 9332 5 that that IN cord-010092-uftc8inx 9332 6 the the DT cord-010092-uftc8inx 9332 7 antibody antibody NN cord-010092-uftc8inx 9332 8 screening screening NN cord-010092-uftc8inx 9332 9 was be VBD cord-010092-uftc8inx 9332 10 positive positive JJ cord-010092-uftc8inx 9332 11 and and CC cord-010092-uftc8inx 9332 12 further further JJ cord-010092-uftc8inx 9332 13 investigation investigation NN cord-010092-uftc8inx 9332 14 was be VBD cord-010092-uftc8inx 9332 15 proceeded proceed VBN cord-010092-uftc8inx 9332 16 . . . cord-010092-uftc8inx 9333 1 Results result NNS cord-010092-uftc8inx 9333 2 : : : cord-010092-uftc8inx 9334 1 Antibody antibody NN cord-010092-uftc8inx 9334 2 screening screening NN cord-010092-uftc8inx 9334 3 showed show VBD cord-010092-uftc8inx 9334 4 trace trace NN cord-010092-uftc8inx 9334 5 positivity positivity NN cord-010092-uftc8inx 9334 6 in in IN cord-010092-uftc8inx 9334 7 both both DT cord-010092-uftc8inx 9334 8 panel panel NN cord-010092-uftc8inx 9334 9 cells cell NNS cord-010092-uftc8inx 9334 10 ( ( -LRB- cord-010092-uftc8inx 9334 11 I I NNP cord-010092-uftc8inx 9334 12 & & CC cord-010092-uftc8inx 9334 13 II II NNP cord-010092-uftc8inx 9334 14 ) ) -RRB- cord-010092-uftc8inx 9334 15 at at IN cord-010092-uftc8inx 9334 16 room room NN cord-010092-uftc8inx 9334 17 temperature temperature NN cord-010092-uftc8inx 9334 18 ( ( -LRB- cord-010092-uftc8inx 9334 19 RT RT NNP cord-010092-uftc8inx 9334 20 ) ) -RRB- cord-010092-uftc8inx 9334 21 and and CC cord-010092-uftc8inx 9334 22 37 37 CD cord-010092-uftc8inx 9334 23 ° ° NN cord-010092-uftc8inx 9334 24 C c NN cord-010092-uftc8inx 9334 25 albumin albumin NN cord-010092-uftc8inx 9334 26 phase phase NN cord-010092-uftc8inx 9334 27 , , , cord-010092-uftc8inx 9334 28 and and CC cord-010092-uftc8inx 9334 29 2 2 CD cord-010092-uftc8inx 9334 30 + + SYM cord-010092-uftc8inx 9334 31 at at IN cord-010092-uftc8inx 9334 32 anti anti JJ cord-010092-uftc8inx 9334 33 - - JJ cord-010092-uftc8inx 9334 34 human human JJ cord-010092-uftc8inx 9334 35 globulin globulin NN cord-010092-uftc8inx 9335 1 ( ( -LRB- cord-010092-uftc8inx 9335 2 AHG AHG NNP cord-010092-uftc8inx 9335 3 ) ) -RRB- cord-010092-uftc8inx 9335 4 phase phase NN cord-010092-uftc8inx 9335 5 by by IN cord-010092-uftc8inx 9335 6 tube tube NN cord-010092-uftc8inx 9335 7 method method NN cord-010092-uftc8inx 9335 8 . . . cord-010092-uftc8inx 9336 1 The the DT cord-010092-uftc8inx 9336 2 auto auto NN cord-010092-uftc8inx 9336 3 control control NN cord-010092-uftc8inx 9336 4 was be VBD cord-010092-uftc8inx 9336 5 negative negative JJ cord-010092-uftc8inx 9336 6 at at IN cord-010092-uftc8inx 9336 7 RT RT NNP cord-010092-uftc8inx 9336 8 and and CC cord-010092-uftc8inx 9336 9 37 37 CD cord-010092-uftc8inx 9336 10 ° ° NN cord-010092-uftc8inx 9336 11 C c NN cord-010092-uftc8inx 9336 12 albumin albumin NN cord-010092-uftc8inx 9336 13 phase phase NN cord-010092-uftc8inx 9336 14 , , , cord-010092-uftc8inx 9336 15 but but CC cord-010092-uftc8inx 9336 16 2 2 CD cord-010092-uftc8inx 9336 17 + + SYM cord-010092-uftc8inx 9336 18 at at IN cord-010092-uftc8inx 9336 19 AHG AHG NNP cord-010092-uftc8inx 9336 20 phase phase NN cord-010092-uftc8inx 9336 21 . . . cord-010092-uftc8inx 9337 1 Antibody antibody NN cord-010092-uftc8inx 9337 2 screening screening NN cord-010092-uftc8inx 9337 3 ( ( -LRB- cord-010092-uftc8inx 9337 4 2 2 CD cord-010092-uftc8inx 9337 5 cells cell NNS cord-010092-uftc8inx 9337 6 ) ) -RRB- cord-010092-uftc8inx 9337 7 and and CC cord-010092-uftc8inx 9337 8 identification identification NN cord-010092-uftc8inx 9337 9 ( ( -LRB- cord-010092-uftc8inx 9337 10 11 11 CD cord-010092-uftc8inx 9337 11 cells cell NNS cord-010092-uftc8inx 9337 12 ) ) -RRB- cord-010092-uftc8inx 9337 13 all all DT cord-010092-uftc8inx 9337 14 showed show VBD cord-010092-uftc8inx 9337 15 3 3 CD cord-010092-uftc8inx 9337 16 + + SYM cord-010092-uftc8inx 9337 17 at at IN cord-010092-uftc8inx 9337 18 AHG AHG NNP cord-010092-uftc8inx 9337 19 phase phase NN cord-010092-uftc8inx 9337 20 using use VBG cord-010092-uftc8inx 9337 21 gel gel NN cord-010092-uftc8inx 9337 22 cards card NNS cord-010092-uftc8inx 9337 23 . . . cord-010092-uftc8inx 9338 1 Direct direct JJ cord-010092-uftc8inx 9338 2 antiglobulin antiglobulin NN cord-010092-uftc8inx 9338 3 test test NN cord-010092-uftc8inx 9338 4 was be VBD cord-010092-uftc8inx 9338 5 4 4 CD cord-010092-uftc8inx 9338 6 + + SYM cord-010092-uftc8inx 9338 7 for for IN cord-010092-uftc8inx 9338 8 anti anti JJ cord-010092-uftc8inx 9338 9 - - JJ cord-010092-uftc8inx 9338 10 IgG igg JJ cord-010092-uftc8inx 9338 11 and and CC cord-010092-uftc8inx 9338 12 3 3 CD cord-010092-uftc8inx 9338 13 + + SYM cord-010092-uftc8inx 9338 14 for for IN cord-010092-uftc8inx 9338 15 anti anti JJ cord-010092-uftc8inx 9338 16 - - JJ cord-010092-uftc8inx 9338 17 C3d c3d JJ cord-010092-uftc8inx 9338 18 using use VBG cord-010092-uftc8inx 9338 19 gel gel NN cord-010092-uftc8inx 9338 20 cards card NNS cord-010092-uftc8inx 9338 21 . . . cord-010092-uftc8inx 9339 1 Two two CD cord-010092-uftc8inx 9339 2 units unit NNS cord-010092-uftc8inx 9339 3 of of IN cord-010092-uftc8inx 9339 4 RBCs rbc NNS cord-010092-uftc8inx 9339 5 were be VBD cord-010092-uftc8inx 9339 6 requested request VBN cord-010092-uftc8inx 9339 7 for for IN cord-010092-uftc8inx 9339 8 transfusion transfusion NN cord-010092-uftc8inx 9339 9 after after IN cord-010092-uftc8inx 9339 10 hemoglobin hemoglobin NN cord-010092-uftc8inx 9339 11 decrease decrease NN cord-010092-uftc8inx 9339 12 to to IN cord-010092-uftc8inx 9339 13 7.8 7.8 CD cord-010092-uftc8inx 9339 14 g g NN cord-010092-uftc8inx 9339 15 / / SYM cord-010092-uftc8inx 9339 16 dL. dl. CC cord-010092-uftc8inx 9339 17 RBC RBC NNP cord-010092-uftc8inx 9339 18 genotyping genotyping NN cord-010092-uftc8inx 9339 19 was be VBD cord-010092-uftc8inx 9339 20 unavailable unavailable JJ cord-010092-uftc8inx 9339 21 at at IN cord-010092-uftc8inx 9339 22 the the DT cord-010092-uftc8inx 9339 23 moment moment NN cord-010092-uftc8inx 9339 24 . . . cord-010092-uftc8inx 9340 1 As as IN cord-010092-uftc8inx 9340 2 her -PRON- PRP$ cord-010092-uftc8inx 9340 3 previous previous JJ cord-010092-uftc8inx 9340 4 antibody antibody NN cord-010092-uftc8inx 9340 5 screening screening NN cord-010092-uftc8inx 9340 6 was be VBD cord-010092-uftc8inx 9340 7 negative negative JJ cord-010092-uftc8inx 9340 8 ( ( -LRB- cord-010092-uftc8inx 9340 9 anti anti JJ cord-010092-uftc8inx 9340 10 - - JJ cord-010092-uftc8inx 9340 11 Jk Jk NNP cord-010092-uftc8inx 9340 12 a a DT cord-010092-uftc8inx 9340 13 not not RB cord-010092-uftc8inx 9340 14 detectable detectable JJ cord-010092-uftc8inx 9340 15 ) ) -RRB- cord-010092-uftc8inx 9340 16 , , , cord-010092-uftc8inx 9340 17 E- E- NNP cord-010092-uftc8inx 9340 18 , , , cord-010092-uftc8inx 9340 19 c- c- XX cord-010092-uftc8inx 9340 20 , , , cord-010092-uftc8inx 9340 21 Fy Fy NNP cord-010092-uftc8inx 9340 22 b b NNP cord-010092-uftc8inx 9340 23 -RBCs -RBCs : cord-010092-uftc8inx 9340 24 were be VBD cord-010092-uftc8inx 9340 25 given give VBN cord-010092-uftc8inx 9340 26 as as IN cord-010092-uftc8inx 9340 27 a a DT cord-010092-uftc8inx 9340 28 second second JJ cord-010092-uftc8inx 9340 29 best good JJS cord-010092-uftc8inx 9340 30 option option NN cord-010092-uftc8inx 9340 31 , , , cord-010092-uftc8inx 9340 32 considering consider VBG cord-010092-uftc8inx 9340 33 the the DT cord-010092-uftc8inx 9340 34 phenotype phenotype NN cord-010092-uftc8inx 9340 35 distribution distribution NN cord-010092-uftc8inx 9340 36 of of IN cord-010092-uftc8inx 9340 37 major major JJ cord-010092-uftc8inx 9340 38 blood blood NN cord-010092-uftc8inx 9340 39 groups group NNS cord-010092-uftc8inx 9340 40 in in IN cord-010092-uftc8inx 9340 41 the the DT cord-010092-uftc8inx 9340 42 Korean korean JJ cord-010092-uftc8inx 9340 43 population population NN cord-010092-uftc8inx 9340 44 . . . cord-010092-uftc8inx 9341 1 The the DT cord-010092-uftc8inx 9341 2 hemoglobin hemoglobin NN cord-010092-uftc8inx 9341 3 level level NN cord-010092-uftc8inx 9341 4 was be VBD cord-010092-uftc8inx 9341 5 well well RB cord-010092-uftc8inx 9341 6 sustained sustain VBN cord-010092-uftc8inx 9341 7 between between IN cord-010092-uftc8inx 9341 8 11.1 11.1 CD cord-010092-uftc8inx 9341 9 - - HYPH cord-010092-uftc8inx 9341 10 12.0 12.0 CD cord-010092-uftc8inx 9341 11 g g NN cord-010092-uftc8inx 9341 12 / / SYM cord-010092-uftc8inx 9341 13 dL dl NN cord-010092-uftc8inx 9342 1 but but CC cord-010092-uftc8inx 9342 2 it -PRON- PRP cord-010092-uftc8inx 9342 3 decreased decrease VBD cord-010092-uftc8inx 9342 4 again again RB cord-010092-uftc8inx 9342 5 to to IN cord-010092-uftc8inx 9342 6 9.2 9.2 CD cord-010092-uftc8inx 9342 7 g g NN cord-010092-uftc8inx 9342 8 / / SYM cord-010092-uftc8inx 9342 9 dL dl NN cord-010092-uftc8inx 9342 10 twenty twenty CD cord-010092-uftc8inx 9342 11 days day NNS cord-010092-uftc8inx 9342 12 after after IN cord-010092-uftc8inx 9342 13 RBC RBC NNP cord-010092-uftc8inx 9342 14 transfusion transfusion NN cord-010092-uftc8inx 9342 15 . . . cord-010092-uftc8inx 9343 1 Further further JJ cord-010092-uftc8inx 9343 2 laboratory laboratory NN cord-010092-uftc8inx 9343 3 investigation investigation NN cord-010092-uftc8inx 9343 4 was be VBD cord-010092-uftc8inx 9343 5 consistent consistent JJ cord-010092-uftc8inx 9343 6 with with IN cord-010092-uftc8inx 9343 7 a a DT cord-010092-uftc8inx 9343 8 DHTR DHTR NNP cord-010092-uftc8inx 9343 9 . . . cord-010092-uftc8inx 9344 1 The the DT cord-010092-uftc8inx 9344 2 patient patient NN cord-010092-uftc8inx 9344 3 was be VBD cord-010092-uftc8inx 9344 4 no no RB cord-010092-uftc8inx 9344 5 longer long RBR cord-010092-uftc8inx 9344 6 being be VBG cord-010092-uftc8inx 9344 7 given give VBN cord-010092-uftc8inx 9344 8 ALX148 ALX148 NNP cord-010092-uftc8inx 9344 9 , , , cord-010092-uftc8inx 9344 10 and and CC cord-010092-uftc8inx 9344 11 antibody antibody NN cord-010092-uftc8inx 9344 12 screening screening NN cord-010092-uftc8inx 9344 13 and and CC cord-010092-uftc8inx 9344 14 DAT DAT NNP cord-010092-uftc8inx 9344 15 decreased decrease VBD cord-010092-uftc8inx 9344 16 to to IN cord-010092-uftc8inx 9344 17 0 0 CD cord-010092-uftc8inx 9344 18 - - SYM cord-010092-uftc8inx 9344 19 1 1 CD cord-010092-uftc8inx 9344 20 + + CC cord-010092-uftc8inx 9344 21 reactivity reactivity NN cord-010092-uftc8inx 9344 22 . . . cord-010092-uftc8inx 9345 1 We -PRON- PRP cord-010092-uftc8inx 9345 2 presumed presume VBD cord-010092-uftc8inx 9345 3 that that DT cord-010092-uftc8inx 9345 4 antigen antigen NN cord-010092-uftc8inx 9345 5 typing typing NN cord-010092-uftc8inx 9345 6 results result NNS cord-010092-uftc8inx 9345 7 would would MD cord-010092-uftc8inx 9345 8 be be VB cord-010092-uftc8inx 9345 9 reliable reliable JJ cord-010092-uftc8inx 9345 10 after after IN cord-010092-uftc8inx 9345 11 chloroquine chloroquine NN cord-010092-uftc8inx 9345 12 dissociation dissociation NN cord-010092-uftc8inx 9345 13 and and CC cord-010092-uftc8inx 9345 14 cell cell NN cord-010092-uftc8inx 9345 15 washing washing NN cord-010092-uftc8inx 9345 16 using use VBG cord-010092-uftc8inx 9345 17 antisera antisera NN cord-010092-uftc8inx 9345 18 that that WDT cord-010092-uftc8inx 9345 19 did do VBD cord-010092-uftc8inx 9345 20 not not RB cord-010092-uftc8inx 9345 21 require require VB cord-010092-uftc8inx 9345 22 AHG AHG NNP cord-010092-uftc8inx 9345 23 for for IN cord-010092-uftc8inx 9345 24 testing testing NN cord-010092-uftc8inx 9345 25 . . . cord-010092-uftc8inx 9346 1 Serologic Serologic NNP cord-010092-uftc8inx 9346 2 phenotyping phenotyping NN cord-010092-uftc8inx 9346 3 showed show VBD cord-010092-uftc8inx 9346 4 that that IN cord-010092-uftc8inx 9346 5 the the DT cord-010092-uftc8inx 9346 6 patient patient NN cord-010092-uftc8inx 9346 7 's 's POS cord-010092-uftc8inx 9346 8 cells cell NNS cord-010092-uftc8inx 9346 9 were be VBD cord-010092-uftc8inx 9346 10 C+ C+ VBN cord-010092-uftc8inx 9346 11 , , , cord-010092-uftc8inx 9346 12 E+ E+ NNP cord-010092-uftc8inx 9346 13 , , , cord-010092-uftc8inx 9346 14 c+ c+ NNP cord-010092-uftc8inx 9346 15 , , , cord-010092-uftc8inx 9346 16 e+ e+ NNP cord-010092-uftc8inx 9346 17 , , , cord-010092-uftc8inx 9346 18 Jk Jk NNP cord-010092-uftc8inx 9347 1 a a LS cord-010092-uftc8inx 9347 2 - - : cord-010092-uftc8inx 9347 3 , , , cord-010092-uftc8inx 9347 4 Jk Jk NNP cord-010092-uftc8inx 9348 1 b b LS cord-010092-uftc8inx 9349 1 + + CC cord-010092-uftc8inx 9350 1 , , , cord-010092-uftc8inx 9350 2 Fy Fy NNP cord-010092-uftc8inx 9350 3 a a DT cord-010092-uftc8inx 9350 4 + + NN cord-010092-uftc8inx 9350 5 , , , cord-010092-uftc8inx 9350 6 Fy Fy NNP cord-010092-uftc8inx 9350 7 b b NNP cord-010092-uftc8inx 9350 8 - - : cord-010092-uftc8inx 9350 9 , , , cord-010092-uftc8inx 9350 10 S- S- NNP cord-010092-uftc8inx 9350 11 , , , cord-010092-uftc8inx 9350 12 s+ s+ NNP cord-010092-uftc8inx 9350 13 , , , cord-010092-uftc8inx 9350 14 M+ M+ NNP cord-010092-uftc8inx 9350 15 , , , cord-010092-uftc8inx 9350 16 N N NNP cord-010092-uftc8inx 9350 17 + + CC cord-010092-uftc8inx 9350 18 . . . cord-010092-uftc8inx 9351 1 Antibody antibody NN cord-010092-uftc8inx 9351 2 identification identification NN cord-010092-uftc8inx 9351 3 using use VBG cord-010092-uftc8inx 9351 4 papainized papainized JJ cord-010092-uftc8inx 9351 5 panel panel NN cord-010092-uftc8inx 9351 6 cells cell NNS cord-010092-uftc8inx 9351 7 revealed reveal VBD cord-010092-uftc8inx 9351 8 anti anti NNP cord-010092-uftc8inx 9351 9 - - NNP cord-010092-uftc8inx 9351 10 Jk Jk NNP cord-010092-uftc8inx 9351 11 a a DT cord-010092-uftc8inx 9351 12 antibody antibody NN cord-010092-uftc8inx 9351 13 . . . cord-010092-uftc8inx 9352 1 We -PRON- PRP cord-010092-uftc8inx 9352 2 concluded conclude VBD cord-010092-uftc8inx 9352 3 that that IN cord-010092-uftc8inx 9352 4 the the DT cord-010092-uftc8inx 9352 5 DHTR DHTR NNP cord-010092-uftc8inx 9352 6 was be VBD cord-010092-uftc8inx 9352 7 due due JJ cord-010092-uftc8inx 9352 8 to to IN cord-010092-uftc8inx 9352 9 anti anti JJ cord-010092-uftc8inx 9352 10 - - JJ cord-010092-uftc8inx 9352 11 Jk Jk NNP cord-010092-uftc8inx 9352 12 a a DT cord-010092-uftc8inx 9352 13 , , , cord-010092-uftc8inx 9352 14 and and CC cord-010092-uftc8inx 9353 1 Jk Jk NNP cord-010092-uftc8inx 9353 2 a a LS cord-010092-uftc8inx 9353 3 - - : cord-010092-uftc8inx 9353 4 , , , cord-010092-uftc8inx 9353 5 Fy Fy NNP cord-010092-uftc8inx 9353 6 b b NNP cord-010092-uftc8inx 9353 7 - - : cord-010092-uftc8inx 9353 8 , , , cord-010092-uftc8inx 9353 9 S S NNP cord-010092-uftc8inx 9353 10 - - HYPH cord-010092-uftc8inx 9353 11 RBCs rbc NNS cord-010092-uftc8inx 9353 12 were be VBD cord-010092-uftc8inx 9353 13 issued issue VBN cord-010092-uftc8inx 9353 14 for for IN cord-010092-uftc8inx 9353 15 further further JJ cord-010092-uftc8inx 9353 16 transfusion transfusion NN cord-010092-uftc8inx 9353 17 requests request NNS cord-010092-uftc8inx 9353 18 . . . cord-010092-uftc8inx 9354 1 The the DT cord-010092-uftc8inx 9354 2 patient patient NN cord-010092-uftc8inx 9354 3 's 's POS cord-010092-uftc8inx 9354 4 hemoglobin hemoglobin NN cord-010092-uftc8inx 9354 5 level level NN cord-010092-uftc8inx 9354 6 recovered recover VBN cord-010092-uftc8inx 9354 7 to to IN cord-010092-uftc8inx 9354 8 13.6 13.6 CD cord-010092-uftc8inx 9354 9 g/ g/ . cord-010092-uftc8inx 9355 1 dL. dL. NNP cord-010092-uftc8inx 9356 1 The the DT cord-010092-uftc8inx 9356 2 patient patient NN cord-010092-uftc8inx 9356 3 's 's POS cord-010092-uftc8inx 9356 4 genotype genotype NN cord-010092-uftc8inx 9356 5 was be VBD cord-010092-uftc8inx 9356 6 later later RB cord-010092-uftc8inx 9356 7 identified identify VBN cord-010092-uftc8inx 9356 8 to to TO cord-010092-uftc8inx 9356 9 be be VB cord-010092-uftc8inx 9356 10 the the DT cord-010092-uftc8inx 9356 11 same same JJ cord-010092-uftc8inx 9356 12 as as IN cord-010092-uftc8inx 9356 13 serologic serologic NNP cord-010092-uftc8inx 9356 14 typing typing NN cord-010092-uftc8inx 9356 15 . . . cord-010092-uftc8inx 9357 1 Summary Summary NNP cord-010092-uftc8inx 9357 2 / / SYM cord-010092-uftc8inx 9357 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 9357 4 : : : cord-010092-uftc8inx 9358 1 Communication communication NN cord-010092-uftc8inx 9358 2 with with IN cord-010092-uftc8inx 9358 3 the the DT cord-010092-uftc8inx 9358 4 physician physician NN cord-010092-uftc8inx 9358 5 and and CC cord-010092-uftc8inx 9358 6 blood blood NN cord-010092-uftc8inx 9358 7 bank bank NN cord-010092-uftc8inx 9358 8 to to TO cord-010092-uftc8inx 9358 9 perform perform VB cord-010092-uftc8inx 9358 10 adequate adequate JJ cord-010092-uftc8inx 9358 11 pretransfusion pretransfusion NN cord-010092-uftc8inx 9358 12 testing testing NN cord-010092-uftc8inx 9358 13 before before IN cord-010092-uftc8inx 9358 14 administration administration NN cord-010092-uftc8inx 9358 15 of of IN cord-010092-uftc8inx 9358 16 drugs drug NNS cord-010092-uftc8inx 9358 17 targeted target VBN cord-010092-uftc8inx 9358 18 to to IN cord-010092-uftc8inx 9358 19 CD47 CD47 NNP cord-010092-uftc8inx 9358 20 is be VBZ cord-010092-uftc8inx 9358 21 important important JJ cord-010092-uftc8inx 9358 22 to to TO cord-010092-uftc8inx 9358 23 achieve achieve VB cord-010092-uftc8inx 9358 24 safe safe JJ cord-010092-uftc8inx 9358 25 transfusion transfusion NN cord-010092-uftc8inx 9358 26 for for IN cord-010092-uftc8inx 9358 27 patients patient NNS cord-010092-uftc8inx 9358 28 . . . cord-010092-uftc8inx 9359 1 Serologic Serologic NNP cord-010092-uftc8inx 9359 2 phenotyping phenotyping NN cord-010092-uftc8inx 9359 3 using use VBG cord-010092-uftc8inx 9359 4 antisera antisera NN cord-010092-uftc8inx 9359 5 which which WDT cord-010092-uftc8inx 9359 6 do do VBP cord-010092-uftc8inx 9359 7 not not RB cord-010092-uftc8inx 9359 8 require require VB cord-010092-uftc8inx 9359 9 AHG AHG NNP cord-010092-uftc8inx 9359 10 for for IN cord-010092-uftc8inx 9359 11 testing testing NN cord-010092-uftc8inx 9359 12 can can MD cord-010092-uftc8inx 9359 13 be be VB cord-010092-uftc8inx 9359 14 used use VBN cord-010092-uftc8inx 9359 15 as as IN cord-010092-uftc8inx 9359 16 a a DT cord-010092-uftc8inx 9359 17 second second JJ cord-010092-uftc8inx 9359 18 option option NN cord-010092-uftc8inx 9359 19 when when WRB cord-010092-uftc8inx 9359 20 genotyping genotyping NN cord-010092-uftc8inx 9359 21 is be VBZ cord-010092-uftc8inx 9359 22 unavailable unavailable JJ cord-010092-uftc8inx 9359 23 in in IN cord-010092-uftc8inx 9359 24 a a DT cord-010092-uftc8inx 9359 25 timely timely JJ cord-010092-uftc8inx 9359 26 manner manner NN cord-010092-uftc8inx 9359 27 . . . cord-010092-uftc8inx 9360 1 Background background NN cord-010092-uftc8inx 9360 2 : : : cord-010092-uftc8inx 9361 1 Transfusion transfusion NN cord-010092-uftc8inx 9361 2 is be VBZ cord-010092-uftc8inx 9361 3 still still RB cord-010092-uftc8inx 9361 4 a a DT cord-010092-uftc8inx 9361 5 key key JJ cord-010092-uftc8inx 9361 6 treatment treatment NN cord-010092-uftc8inx 9361 7 for for IN cord-010092-uftc8inx 9361 8 sickle sickle NN cord-010092-uftc8inx 9361 9 cell cell NN cord-010092-uftc8inx 9361 10 disease disease NN cord-010092-uftc8inx 9361 11 ( ( -LRB- cord-010092-uftc8inx 9361 12 SCD SCD NNP cord-010092-uftc8inx 9361 13 ) ) -RRB- cord-010092-uftc8inx 9361 14 patients patient NNS cord-010092-uftc8inx 9361 15 . . . cord-010092-uftc8inx 9362 1 As as IN cord-010092-uftc8inx 9362 2 a a DT cord-010092-uftc8inx 9362 3 result result NN cord-010092-uftc8inx 9362 4 , , , cord-010092-uftc8inx 9362 5 these these DT cord-010092-uftc8inx 9362 6 patients patient NNS cord-010092-uftc8inx 9362 7 are be VBP cord-010092-uftc8inx 9362 8 much much RB cord-010092-uftc8inx 9362 9 more more RBR cord-010092-uftc8inx 9362 10 exposed expose VBN cord-010092-uftc8inx 9362 11 to to IN cord-010092-uftc8inx 9362 12 transfusions transfusion NNS cord-010092-uftc8inx 9362 13 ' ' POS cord-010092-uftc8inx 9362 14 risks risk NNS cord-010092-uftc8inx 9362 15 , , , cord-010092-uftc8inx 9362 16 the the DT cord-010092-uftc8inx 9362 17 most most RBS cord-010092-uftc8inx 9362 18 feared fear VBN cord-010092-uftc8inx 9362 19 one one CD cord-010092-uftc8inx 9362 20 being be VBG cord-010092-uftc8inx 9362 21 a a DT cord-010092-uftc8inx 9362 22 delayed delay VBN cord-010092-uftc8inx 9362 23 hemolytic hemolytic JJ cord-010092-uftc8inx 9362 24 transfusion transfusion NN cord-010092-uftc8inx 9362 25 reaction reaction NN cord-010092-uftc8inx 9362 26 ( ( -LRB- cord-010092-uftc8inx 9362 27 DHTR DHTR NNP cord-010092-uftc8inx 9362 28 ) ) -RRB- cord-010092-uftc8inx 9362 29 . . . cord-010092-uftc8inx 9363 1 We -PRON- PRP cord-010092-uftc8inx 9363 2 investigated investigate VBD cord-010092-uftc8inx 9363 3 a a DT cord-010092-uftc8inx 9363 4 female female JJ cord-010092-uftc8inx 9363 5 SCD SCD NNP cord-010092-uftc8inx 9363 6 pediatric pediatric JJ cord-010092-uftc8inx 9363 7 patient patient NN cord-010092-uftc8inx 9363 8 with with IN cord-010092-uftc8inx 9363 9 no no DT cord-010092-uftc8inx 9363 10 known know VBN cord-010092-uftc8inx 9363 11 antibody antibody NN cord-010092-uftc8inx 9363 12 , , , cord-010092-uftc8inx 9363 13 who who WP cord-010092-uftc8inx 9363 14 was be VBD cord-010092-uftc8inx 9363 15 referred refer VBN cord-010092-uftc8inx 9363 16 to to IN cord-010092-uftc8inx 9363 17 us -PRON- PRP cord-010092-uftc8inx 9363 18 for for IN cord-010092-uftc8inx 9363 19 a a DT cord-010092-uftc8inx 9363 20 suspicion suspicion NN cord-010092-uftc8inx 9363 21 of of IN cord-010092-uftc8inx 9363 22 two two CD cord-010092-uftc8inx 9363 23 DHTRs dhtr NNS cord-010092-uftc8inx 9363 24 . . . cord-010092-uftc8inx 9364 1 Three three CD cord-010092-uftc8inx 9364 2 transfusion transfusion NN cord-010092-uftc8inx 9364 3 episodes episode NNS cord-010092-uftc8inx 9364 4 were be VBD cord-010092-uftc8inx 9364 5 reported report VBN cord-010092-uftc8inx 9364 6 ( ( -LRB- cord-010092-uftc8inx 9364 7 a a DT cord-010092-uftc8inx 9364 8 total total NN cord-010092-uftc8inx 9364 9 of of IN cord-010092-uftc8inx 9364 10 four four CD cord-010092-uftc8inx 9364 11 units unit NNS cord-010092-uftc8inx 9364 12 collected collect VBN cord-010092-uftc8inx 9364 13 from from IN cord-010092-uftc8inx 9364 14 four four CD cord-010092-uftc8inx 9364 15 donors donor NNS cord-010092-uftc8inx 9364 16 ) ) -RRB- cord-010092-uftc8inx 9364 17 . . . cord-010092-uftc8inx 9365 1 For for IN cord-010092-uftc8inx 9365 2 the the DT cord-010092-uftc8inx 9365 3 last last JJ cord-010092-uftc8inx 9365 4 transfusion transfusion NN cord-010092-uftc8inx 9365 5 , , , cord-010092-uftc8inx 9365 6 a a DT cord-010092-uftc8inx 9365 7 premedication premedication NN cord-010092-uftc8inx 9365 8 with with IN cord-010092-uftc8inx 9365 9 rituximab rituximab NNP cord-010092-uftc8inx 9365 10 was be VBD cord-010092-uftc8inx 9365 11 done do VBN cord-010092-uftc8inx 9365 12 . . . cord-010092-uftc8inx 9366 1 The the DT cord-010092-uftc8inx 9366 2 patient patient NN cord-010092-uftc8inx 9366 3 was be VBD cord-010092-uftc8inx 9366 4 planned plan VBN cord-010092-uftc8inx 9366 5 to to TO cord-010092-uftc8inx 9366 6 undergo undergo VB cord-010092-uftc8inx 9366 7 a a DT cord-010092-uftc8inx 9366 8 bone bone NN cord-010092-uftc8inx 9366 9 marrow marrow NN cord-010092-uftc8inx 9366 10 transplant transplant NN cord-010092-uftc8inx 9366 11 with with IN cord-010092-uftc8inx 9366 12 her -PRON- PRP$ cord-010092-uftc8inx 9366 13 brother brother NN cord-010092-uftc8inx 9366 14 as as IN cord-010092-uftc8inx 9366 15 her -PRON- PRP$ cord-010092-uftc8inx 9366 16 donor donor NN cord-010092-uftc8inx 9366 17 . . . cord-010092-uftc8inx 9367 1 Aims aim VBZ cord-010092-uftc8inx 9367 2 : : : cord-010092-uftc8inx 9367 3 To to TO cord-010092-uftc8inx 9367 4 describe describe VB cord-010092-uftc8inx 9367 5 the the DT cord-010092-uftc8inx 9367 6 molecular molecular JJ cord-010092-uftc8inx 9367 7 and and CC cord-010092-uftc8inx 9367 8 serological serological JJ cord-010092-uftc8inx 9367 9 workups workup NNS cord-010092-uftc8inx 9367 10 needed need VBN cord-010092-uftc8inx 9367 11 to to TO cord-010092-uftc8inx 9367 12 investigate investigate VB cord-010092-uftc8inx 9367 13 a a DT cord-010092-uftc8inx 9367 14 DHTR dhtr NN cord-010092-uftc8inx 9367 15 in in IN cord-010092-uftc8inx 9367 16 a a DT cord-010092-uftc8inx 9367 17 SCD SCD NNP cord-010092-uftc8inx 9367 18 patient patient NN cord-010092-uftc8inx 9367 19 . . . cord-010092-uftc8inx 9368 1 Methods method NNS cord-010092-uftc8inx 9368 2 : : : cord-010092-uftc8inx 9369 1 Antibody antibody NN cord-010092-uftc8inx 9369 2 identification identification NN cord-010092-uftc8inx 9369 3 and and CC cord-010092-uftc8inx 9369 4 crossmatches crossmatche NNS cord-010092-uftc8inx 9369 5 were be VBD cord-010092-uftc8inx 9369 6 performed perform VBN cord-010092-uftc8inx 9369 7 by by IN cord-010092-uftc8inx 9369 8 IAT IAT NNP cord-010092-uftc8inx 9369 9 gel gel NN cord-010092-uftc8inx 9369 10 testing testing NN cord-010092-uftc8inx 9369 11 with with IN cord-010092-uftc8inx 9369 12 Red Red NNP cord-010092-uftc8inx 9369 13 Blood Blood NNP cord-010092-uftc8inx 9369 14 Cells cell NNS cord-010092-uftc8inx 9369 15 / / SYM cord-010092-uftc8inx 9369 16 panels panel NNS cord-010092-uftc8inx 9369 17 , , , cord-010092-uftc8inx 9369 18 which which WDT cord-010092-uftc8inx 9369 19 were be VBD cord-010092-uftc8inx 9369 20 used use VBN cord-010092-uftc8inx 9369 21 raw raw JJ cord-010092-uftc8inx 9369 22 , , , cord-010092-uftc8inx 9369 23 papain papain NN cord-010092-uftc8inx 9369 24 - - HYPH cord-010092-uftc8inx 9369 25 treated treat VBN cord-010092-uftc8inx 9369 26 and and CC cord-010092-uftc8inx 9369 27 trypsintreated trypsintreate VBN cord-010092-uftc8inx 9369 28 . . . cord-010092-uftc8inx 9370 1 RBCs rbc NNS cord-010092-uftc8inx 9370 2 ' ' POS cord-010092-uftc8inx 9370 3 phenotypes phenotype NNS cord-010092-uftc8inx 9370 4 were be VBD cord-010092-uftc8inx 9370 5 determined determine VBN cord-010092-uftc8inx 9370 6 by by IN cord-010092-uftc8inx 9370 7 conventional conventional JJ cord-010092-uftc8inx 9370 8 techniques technique NNS cord-010092-uftc8inx 9370 9 . . . cord-010092-uftc8inx 9371 1 Semi semi JJ cord-010092-uftc8inx 9371 2 - - JJ cord-010092-uftc8inx 9371 3 quantitative quantitative JJ cord-010092-uftc8inx 9371 4 phenotypes phenotype NNS cord-010092-uftc8inx 9371 5 were be VBD cord-010092-uftc8inx 9371 6 conducted conduct VBN cord-010092-uftc8inx 9371 7 by by IN cord-010092-uftc8inx 9371 8 serial serial JJ cord-010092-uftc8inx 9371 9 dilutions dilution NNS cord-010092-uftc8inx 9371 10 with with IN cord-010092-uftc8inx 9371 11 a a DT cord-010092-uftc8inx 9371 12 monoclonal monoclonal JJ cord-010092-uftc8inx 9371 13 anti anti NN cord-010092-uftc8inx 9371 14 - - NN cord-010092-uftc8inx 9371 15 Jk Jk NNP cord-010092-uftc8inx 9372 1 a a LS cord-010092-uftc8inx 9372 2 ( ( -LRB- cord-010092-uftc8inx 9372 3 MS15 MS15 NNP cord-010092-uftc8inx 9372 4 / / SYM cord-010092-uftc8inx 9372 5 Seraclone Seraclone NNP cord-010092-uftc8inx 9372 6 â â , cord-010092-uftc8inx 9372 7 ) ) -RRB- cord-010092-uftc8inx 9372 8 . . . cord-010092-uftc8inx 9373 1 DNA DNA NNP cord-010092-uftc8inx 9373 2 was be VBD cord-010092-uftc8inx 9373 3 extracted extract VBN cord-010092-uftc8inx 9373 4 using use VBG cord-010092-uftc8inx 9373 5 the the DT cord-010092-uftc8inx 9373 6 MagNA MagNA NNP cord-010092-uftc8inx 9373 7 Pure Pure NNP cord-010092-uftc8inx 9373 8 Compact Compact NNP cord-010092-uftc8inx 9373 9 Instrument Instrument NNP cord-010092-uftc8inx 9373 10 ( ( -LRB- cord-010092-uftc8inx 9373 11 Roche Roche NNP cord-010092-uftc8inx 9373 12 ) ) -RRB- cord-010092-uftc8inx 9373 13 . . . cord-010092-uftc8inx 9374 1 Sequencing sequencing NN cord-010092-uftc8inx 9374 2 of of IN cord-010092-uftc8inx 9374 3 JK JK NNP cord-010092-uftc8inx 9374 4 exons exon NNS cord-010092-uftc8inx 9374 5 4 4 CD cord-010092-uftc8inx 9374 6 - - SYM cord-010092-uftc8inx 9374 7 11 11 CD cord-010092-uftc8inx 9374 8 was be VBD cord-010092-uftc8inx 9374 9 carried carry VBN cord-010092-uftc8inx 9374 10 out out RP cord-010092-uftc8inx 9374 11 by by IN cord-010092-uftc8inx 9374 12 in in IN cord-010092-uftc8inx 9374 13 - - HYPH cord-010092-uftc8inx 9374 14 house house NN cord-010092-uftc8inx 9374 15 techniques technique NNS cord-010092-uftc8inx 9374 16 . . . cord-010092-uftc8inx 9375 1 Results result NNS cord-010092-uftc8inx 9375 2 : : : cord-010092-uftc8inx 9376 1 The the DT cord-010092-uftc8inx 9376 2 antibody antibody NN cord-010092-uftc8inx 9376 3 identification identification NN cord-010092-uftc8inx 9376 4 showed show VBD cord-010092-uftc8inx 9376 5 a a DT cord-010092-uftc8inx 9376 6 very very RB cord-010092-uftc8inx 9376 7 weak weak JJ cord-010092-uftc8inx 9376 8 anti anti AFX cord-010092-uftc8inx 9376 9 - - JJ cord-010092-uftc8inx 9376 10 Jk Jk NNP cord-010092-uftc8inx 9376 11 a a DT cord-010092-uftc8inx 9376 12 , , , cord-010092-uftc8inx 9376 13 which which WDT cord-010092-uftc8inx 9376 14 was be VBD cord-010092-uftc8inx 9376 15 only only RB cord-010092-uftc8inx 9376 16 reactive reactive JJ cord-010092-uftc8inx 9376 17 on on IN cord-010092-uftc8inx 9376 18 papain papain NN cord-010092-uftc8inx 9376 19 - - HYPH cord-010092-uftc8inx 9376 20 treated treat VBN cord-010092-uftc8inx 9376 21 RBCs rbc NNS cord-010092-uftc8inx 9376 22 . . . cord-010092-uftc8inx 9377 1 Autologous autologous JJ cord-010092-uftc8inx 9377 2 control control NN cord-010092-uftc8inx 9377 3 was be VBD cord-010092-uftc8inx 9377 4 also also RB cord-010092-uftc8inx 9377 5 only only RB cord-010092-uftc8inx 9377 6 positive positive JJ cord-010092-uftc8inx 9377 7 in in IN cord-010092-uftc8inx 9377 8 this this DT cord-010092-uftc8inx 9377 9 technique technique NN cord-010092-uftc8inx 9377 10 . . . cord-010092-uftc8inx 9378 1 DAT DAT NNP cord-010092-uftc8inx 9378 2 and and CC cord-010092-uftc8inx 9378 3 the the DT cord-010092-uftc8inx 9378 4 eluate eluate NN cord-010092-uftc8inx 9378 5 were be VBD cord-010092-uftc8inx 9378 6 negative negative JJ cord-010092-uftc8inx 9378 7 . . . cord-010092-uftc8inx 9379 1 As as IN cord-010092-uftc8inx 9379 2 the the DT cord-010092-uftc8inx 9379 3 patient patient NN cord-010092-uftc8inx 9379 4 had have VBD cord-010092-uftc8inx 9379 5 recently recently RB cord-010092-uftc8inx 9379 6 been be VBN cord-010092-uftc8inx 9379 7 transfused transfuse VBN cord-010092-uftc8inx 9379 8 ( ( -LRB- cord-010092-uftc8inx 9379 9 less less JJR cord-010092-uftc8inx 9379 10 than than IN cord-010092-uftc8inx 9379 11 four four CD cord-010092-uftc8inx 9379 12 months month NNS cord-010092-uftc8inx 9379 13 earlier early RBR cord-010092-uftc8inx 9379 14 ) ) -RRB- cord-010092-uftc8inx 9379 15 , , , cord-010092-uftc8inx 9379 16 on on IN cord-010092-uftc8inx 9379 17 this this DT cord-010092-uftc8inx 9379 18 first first JJ cord-010092-uftc8inx 9379 19 sample sample NN cord-010092-uftc8inx 9379 20 we -PRON- PRP cord-010092-uftc8inx 9379 21 were be VBD cord-010092-uftc8inx 9379 22 neither neither CC cord-010092-uftc8inx 9379 23 able able JJ cord-010092-uftc8inx 9379 24 to to TO cord-010092-uftc8inx 9379 25 perform perform VB cord-010092-uftc8inx 9379 26 autologous autologous JJ cord-010092-uftc8inx 9379 27 adsorptions adsorption NNS cord-010092-uftc8inx 9379 28 , , , cord-010092-uftc8inx 9379 29 nor nor CC cord-010092-uftc8inx 9379 30 verify verify VB cord-010092-uftc8inx 9379 31 her -PRON- PRP cord-010092-uftc8inx 9379 32 Jk Jk NNP cord-010092-uftc8inx 9379 33 a a DT cord-010092-uftc8inx 9379 34 /Jk /jk NN cord-010092-uftc8inx 9379 35 b b NN cord-010092-uftc8inx 9379 36 phenotypes phenotype NNS cord-010092-uftc8inx 9379 37 . . . cord-010092-uftc8inx 9380 1 In in IN cord-010092-uftc8inx 9380 2 order order NN cord-010092-uftc8inx 9380 3 to to TO cord-010092-uftc8inx 9380 4 rule rule VB cord-010092-uftc8inx 9380 5 out out RP cord-010092-uftc8inx 9380 6 the the DT cord-010092-uftc8inx 9380 7 imputability imputability NN cord-010092-uftc8inx 9380 8 of of IN cord-010092-uftc8inx 9380 9 an an DT cord-010092-uftc8inx 9380 10 anti anti JJ cord-010092-uftc8inx 9380 11 - - JJ cord-010092-uftc8inx 9380 12 LFA LFA NNP cord-010092-uftc8inx 9380 13 in in IN cord-010092-uftc8inx 9380 14 the the DT cord-010092-uftc8inx 9380 15 DHTR DHTR NNP cord-010092-uftc8inx 9380 16 outcome outcome NN cord-010092-uftc8inx 9380 17 , , , cord-010092-uftc8inx 9380 18 crossmatches crossmatche VBZ cord-010092-uftc8inx 9380 19 with with IN cord-010092-uftc8inx 9380 20 her -PRON- PRP$ cord-010092-uftc8inx 9380 21 donors donor NNS cord-010092-uftc8inx 9380 22 ' ' POS cord-010092-uftc8inx 9380 23 RBCs rbc NNS cord-010092-uftc8inx 9380 24 were be VBD cord-010092-uftc8inx 9380 25 undertaken undertake VBN cord-010092-uftc8inx 9380 26 . . . cord-010092-uftc8inx 9381 1 Three three CD cord-010092-uftc8inx 9381 2 out out IN cord-010092-uftc8inx 9381 3 of of IN cord-010092-uftc8inx 9381 4 the the DT cord-010092-uftc8inx 9381 5 four four CD cord-010092-uftc8inx 9381 6 donors donor NNS cord-010092-uftc8inx 9381 7 were be VBD cord-010092-uftc8inx 9381 8 tested test VBN cord-010092-uftc8inx 9381 9 . . . cord-010092-uftc8inx 9382 1 Apart apart RB cord-010092-uftc8inx 9382 2 from from IN cord-010092-uftc8inx 9382 3 the the DT cord-010092-uftc8inx 9382 4 anti anti NNP cord-010092-uftc8inx 9382 5 - - JJ cord-010092-uftc8inx 9382 6 Jk Jk NNP cord-010092-uftc8inx 9382 7 a a DT cord-010092-uftc8inx 9382 8 reactivity reactivity NN cord-010092-uftc8inx 9382 9 , , , cord-010092-uftc8inx 9382 10 none none NN cord-010092-uftc8inx 9382 11 of of IN cord-010092-uftc8inx 9382 12 them -PRON- PRP cord-010092-uftc8inx 9382 13 was be VBD cord-010092-uftc8inx 9382 14 reactive reactive JJ cord-010092-uftc8inx 9382 15 . . . cord-010092-uftc8inx 9383 1 Because because IN cord-010092-uftc8inx 9383 2 the the DT cord-010092-uftc8inx 9383 3 patient patient NN cord-010092-uftc8inx 9383 4 had have VBD cord-010092-uftc8inx 9383 5 previously previously RB cord-010092-uftc8inx 9383 6 been be VBN cord-010092-uftc8inx 9383 7 phenotyped phenotype VBN cord-010092-uftc8inx 9383 8 as as IN cord-010092-uftc8inx 9383 9 Jk(a+b+ Jk(a+b+ NNP cord-010092-uftc8inx 9383 10 ) ) -RRB- cord-010092-uftc8inx 9383 11 , , , cord-010092-uftc8inx 9383 12 her -PRON- PRP$ cord-010092-uftc8inx 9383 13 JK JK NNP cord-010092-uftc8inx 9383 14 gene gene NN cord-010092-uftc8inx 9383 15 was be VBD cord-010092-uftc8inx 9383 16 sequenced sequence VBN cord-010092-uftc8inx 9383 17 . . . cord-010092-uftc8inx 9384 1 Her -PRON- PRP$ cord-010092-uftc8inx 9384 2 genotype genotype NN cord-010092-uftc8inx 9384 3 was be VBD cord-010092-uftc8inx 9384 4 determined determine VBN cord-010092-uftc8inx 9384 5 as as IN cord-010092-uftc8inx 9384 6 JK*01(28A,226A,303A,588G)/JK*02 JK*01(28A,226A,303A,588G)/JK*02 NNP cord-010092-uftc8inx 9384 7 . . . cord-010092-uftc8inx 9385 1 To to TO cord-010092-uftc8inx 9385 2 confirm confirm VB cord-010092-uftc8inx 9385 3 this this DT cord-010092-uftc8inx 9385 4 Jk Jk NNP cord-010092-uftc8inx 9386 1 a a DT cord-010092-uftc8inx 9386 2 variant variant JJ cord-010092-uftc8inx 9386 3 allele allele NN cord-010092-uftc8inx 9386 4 , , , cord-010092-uftc8inx 9386 5 a a DT cord-010092-uftc8inx 9386 6 family family NN cord-010092-uftc8inx 9386 7 study study NN cord-010092-uftc8inx 9386 8 was be VBD cord-010092-uftc8inx 9386 9 conducted conduct VBN cord-010092-uftc8inx 9386 10 . . . cord-010092-uftc8inx 9387 1 All all DT cord-010092-uftc8inx 9387 2 her -PRON- PRP$ cord-010092-uftc8inx 9387 3 siblings sibling NNS cord-010092-uftc8inx 9387 4 were be VBD cord-010092-uftc8inx 9387 5 found find VBN cord-010092-uftc8inx 9387 6 to to TO cord-010092-uftc8inx 9387 7 harbor harbor VB cord-010092-uftc8inx 9387 8 the the DT cord-010092-uftc8inx 9387 9 same same JJ cord-010092-uftc8inx 9387 10 genotype genotype NN cord-010092-uftc8inx 9387 11 . . . cord-010092-uftc8inx 9388 1 Her -PRON- PRP$ cord-010092-uftc8inx 9388 2 mother mother NN cord-010092-uftc8inx 9388 3 's 's POS cord-010092-uftc8inx 9388 4 and and CC cord-010092-uftc8inx 9388 5 father father NN cord-010092-uftc8inx 9388 6 's 's POS cord-010092-uftc8inx 9388 7 genotypes genotype NNS cord-010092-uftc8inx 9388 8 were be VBD cord-010092-uftc8inx 9388 9 JK*01(28A,226A,303A,588G)/ JK*01(28A,226A,303A,588G)/ NNP cord-010092-uftc8inx 9389 1 JK*01 JK*01 NNP cord-010092-uftc8inx 9390 1 and and CC cord-010092-uftc8inx 9390 2 JK*02 JK*02 NNP cord-010092-uftc8inx 9390 3 / / SYM cord-010092-uftc8inx 9390 4 JK*02 JK*02 NNS cord-010092-uftc8inx 9390 5 , , , cord-010092-uftc8inx 9390 6 respectively respectively RB cord-010092-uftc8inx 9390 7 . . . cord-010092-uftc8inx 9391 1 Subsequently subsequently RB cord-010092-uftc8inx 9391 2 , , , cord-010092-uftc8inx 9391 3 autologous autologous JJ cord-010092-uftc8inx 9391 4 adsorptions adsorption NNS cord-010092-uftc8inx 9391 5 were be VBD cord-010092-uftc8inx 9391 6 performed perform VBN cord-010092-uftc8inx 9391 7 , , , cord-010092-uftc8inx 9391 8 which which WDT cord-010092-uftc8inx 9391 9 proved prove VBD cord-010092-uftc8inx 9391 10 the the DT cord-010092-uftc8inx 9391 11 anti anti JJ cord-010092-uftc8inx 9391 12 - - NN cord-010092-uftc8inx 9391 13 Jk Jk NNP cord-010092-uftc8inx 9391 14 a a DT cord-010092-uftc8inx 9391 15 to to TO cord-010092-uftc8inx 9391 16 be be VB cord-010092-uftc8inx 9391 17 an an DT cord-010092-uftc8inx 9391 18 autoantibody autoantibody NN cord-010092-uftc8inx 9391 19 . . . cord-010092-uftc8inx 9392 1 Considering consider VBG cord-010092-uftc8inx 9392 2 the the DT cord-010092-uftc8inx 9392 3 weakness weakness NN cord-010092-uftc8inx 9392 4 of of IN cord-010092-uftc8inx 9392 5 this this DT cord-010092-uftc8inx 9392 6 antibody antibody NN cord-010092-uftc8inx 9392 7 , , , cord-010092-uftc8inx 9392 8 internal internal JJ cord-010092-uftc8inx 9392 9 controls control NNS cord-010092-uftc8inx 9392 10 were be VBD cord-010092-uftc8inx 9392 11 used use VBN cord-010092-uftc8inx 9392 12 , , , cord-010092-uftc8inx 9392 13 in in IN cord-010092-uftc8inx 9392 14 order order NN cord-010092-uftc8inx 9392 15 to to TO cord-010092-uftc8inx 9392 16 evaluate evaluate VB cord-010092-uftc8inx 9392 17 a a DT cord-010092-uftc8inx 9392 18 possible possible JJ cord-010092-uftc8inx 9392 19 dilution dilution NN cord-010092-uftc8inx 9392 20 effect effect NN cord-010092-uftc8inx 9392 21 of of IN cord-010092-uftc8inx 9392 22 this this DT cord-010092-uftc8inx 9392 23 technique technique NN cord-010092-uftc8inx 9392 24 . . . cord-010092-uftc8inx 9393 1 Finally finally RB cord-010092-uftc8inx 9393 2 , , , cord-010092-uftc8inx 9393 3 serial serial JJ cord-010092-uftc8inx 9393 4 dilutions dilution NNS cord-010092-uftc8inx 9393 5 with with IN cord-010092-uftc8inx 9393 6 the the DT cord-010092-uftc8inx 9393 7 anti anti NN cord-010092-uftc8inx 9393 8 - - NN cord-010092-uftc8inx 9393 9 Jk Jk NNP cord-010092-uftc8inx 9394 1 a a DT cord-010092-uftc8inx 9394 2 reagent reagent NN cord-010092-uftc8inx 9394 3 showed show VBD cord-010092-uftc8inx 9394 4 a a DT cord-010092-uftc8inx 9394 5 weakened weakened JJ cord-010092-uftc8inx 9394 6 Jk Jk NNP cord-010092-uftc8inx 9394 7 a a DT cord-010092-uftc8inx 9394 8 expression expression NN cord-010092-uftc8inx 9394 9 encoded encode VBN cord-010092-uftc8inx 9394 10 by by IN cord-010092-uftc8inx 9394 11 the the DT cord-010092-uftc8inx 9394 12 JK*01(28A,226A,303A,588 JK*01(28A,226A,303A,588 NNP cord-010092-uftc8inx 9394 13 G G NNP cord-010092-uftc8inx 9394 14 ) ) -RRB- cord-010092-uftc8inx 9394 15 variant variant NN cord-010092-uftc8inx 9394 16 allele allele NN cord-010092-uftc8inx 9394 17 . . . cord-010092-uftc8inx 9395 1 This this DT cord-010092-uftc8inx 9395 2 finding finding NN cord-010092-uftc8inx 9395 3 is be VBZ cord-010092-uftc8inx 9395 4 consistent consistent JJ cord-010092-uftc8inx 9395 5 with with IN cord-010092-uftc8inx 9395 6 the the DT cord-010092-uftc8inx 9395 7 fact fact NN cord-010092-uftc8inx 9395 8 that that IN cord-010092-uftc8inx 9395 9 the the DT cord-010092-uftc8inx 9395 10 crossmatches crossmatche NNS cord-010092-uftc8inx 9395 11 between between IN cord-010092-uftc8inx 9395 12 the the DT cord-010092-uftc8inx 9395 13 proband proband NN cord-010092-uftc8inx 9395 14 's 's POS cord-010092-uftc8inx 9395 15 serum serum NN cord-010092-uftc8inx 9395 16 and and CC cord-010092-uftc8inx 9395 17 her -PRON- PRP$ cord-010092-uftc8inx 9395 18 brother brother NN cord-010092-uftc8inx 9395 19 's 's POS cord-010092-uftc8inx 9395 20 RBCs rbc NNS cord-010092-uftc8inx 9395 21 were be VBD cord-010092-uftc8inx 9395 22 weaker weak JJR cord-010092-uftc8inx 9395 23 than than IN cord-010092-uftc8inx 9395 24 those those DT cord-010092-uftc8inx 9395 25 performed perform VBN cord-010092-uftc8inx 9395 26 with with IN cord-010092-uftc8inx 9395 27 ( ( -LRB- cord-010092-uftc8inx 9395 28 Jka+b+ Jka+b+ NNP cord-010092-uftc8inx 9395 29 ) ) -RRB- cord-010092-uftc8inx 9395 30 RBCs rbc NNS cord-010092-uftc8inx 9395 31 . . . cord-010092-uftc8inx 9396 1 Summary Summary NNP cord-010092-uftc8inx 9396 2 / / SYM cord-010092-uftc8inx 9396 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 9396 4 : : : cord-010092-uftc8inx 9396 5 About about RB cord-010092-uftc8inx 9396 6 a a DT cord-010092-uftc8inx 9396 7 third third NN cord-010092-uftc8inx 9396 8 of of IN cord-010092-uftc8inx 9396 9 DHTRs dhtr NNS cord-010092-uftc8inx 9396 10 are be VBP cord-010092-uftc8inx 9396 11 reported report VBN cord-010092-uftc8inx 9396 12 to to TO cord-010092-uftc8inx 9396 13 happen happen VB cord-010092-uftc8inx 9396 14 in in IN cord-010092-uftc8inx 9396 15 patients patient NNS cord-010092-uftc8inx 9396 16 with with IN cord-010092-uftc8inx 9396 17 no no DT cord-010092-uftc8inx 9396 18 previous previous JJ cord-010092-uftc8inx 9396 19 history history NN cord-010092-uftc8inx 9396 20 of of IN cord-010092-uftc8inx 9396 21 immunization immunization NN cord-010092-uftc8inx 9396 22 . . . cord-010092-uftc8inx 9397 1 Performing perform VBG cord-010092-uftc8inx 9397 2 sensitive sensitive JJ cord-010092-uftc8inx 9397 3 serological serological JJ cord-010092-uftc8inx 9397 4 techniques technique NNS cord-010092-uftc8inx 9397 5 in in IN cord-010092-uftc8inx 9397 6 order order NN cord-010092-uftc8inx 9397 7 to to TO cord-010092-uftc8inx 9397 8 identify identify VB cord-010092-uftc8inx 9397 9 antibodies antibody NNS cord-010092-uftc8inx 9397 10 is be VBZ cord-010092-uftc8inx 9397 11 necessary necessary JJ cord-010092-uftc8inx 9397 12 to to TO cord-010092-uftc8inx 9397 13 select select VB cord-010092-uftc8inx 9397 14 the the DT cord-010092-uftc8inx 9397 15 most most RBS cord-010092-uftc8inx 9397 16 appropriate appropriate JJ cord-010092-uftc8inx 9397 17 units unit NNS cord-010092-uftc8inx 9397 18 . . . cord-010092-uftc8inx 9398 1 Molecular molecular JJ cord-010092-uftc8inx 9398 2 work work NN cord-010092-uftc8inx 9398 3 and and CC cord-010092-uftc8inx 9398 4 extra extra JJ cord-010092-uftc8inx 9398 5 serological serological JJ cord-010092-uftc8inx 9398 6 testing testing NN cord-010092-uftc8inx 9398 7 can can MD cord-010092-uftc8inx 9398 8 be be VB cord-010092-uftc8inx 9398 9 useful useful JJ cord-010092-uftc8inx 9398 10 to to TO cord-010092-uftc8inx 9398 11 determine determine VB cord-010092-uftc8inx 9398 12 whether whether IN cord-010092-uftc8inx 9398 13 an an DT cord-010092-uftc8inx 9398 14 antibody antibody NN cord-010092-uftc8inx 9398 15 is be VBZ cord-010092-uftc8inx 9398 16 an an DT cord-010092-uftc8inx 9398 17 allo allo NN cord-010092-uftc8inx 9398 18 or or CC cord-010092-uftc8inx 9398 19 autoantibody autoantibody NN cord-010092-uftc8inx 9398 20 . . . cord-010092-uftc8inx 9399 1 Even even RB cord-010092-uftc8inx 9399 2 though though IN cord-010092-uftc8inx 9399 3 in in IN cord-010092-uftc8inx 9399 4 this this DT cord-010092-uftc8inx 9399 5 case case NN cord-010092-uftc8inx 9399 6 the the DT cord-010092-uftc8inx 9399 7 anti anti JJ cord-010092-uftc8inx 9399 8 - - JJ cord-010092-uftc8inx 9399 9 Jk Jk NNP cord-010092-uftc8inx 9399 10 a a DT cord-010092-uftc8inx 9399 11 was be VBD cord-010092-uftc8inx 9399 12 the the DT cord-010092-uftc8inx 9399 13 only only JJ cord-010092-uftc8inx 9399 14 antibody antibody NN cord-010092-uftc8inx 9399 15 identified identify VBN cord-010092-uftc8inx 9399 16 , , , cord-010092-uftc8inx 9399 17 because because IN cord-010092-uftc8inx 9399 18 it -PRON- PRP cord-010092-uftc8inx 9399 19 was be VBD cord-010092-uftc8inx 9399 20 proven prove VBN cord-010092-uftc8inx 9399 21 to to TO cord-010092-uftc8inx 9399 22 be be VB cord-010092-uftc8inx 9399 23 an an DT cord-010092-uftc8inx 9399 24 autoantibody autoantibody NN cord-010092-uftc8inx 9399 25 , , , cord-010092-uftc8inx 9399 26 it -PRON- PRP cord-010092-uftc8inx 9399 27 is be VBZ cord-010092-uftc8inx 9399 28 difficult difficult JJ cord-010092-uftc8inx 9399 29 to to TO cord-010092-uftc8inx 9399 30 conclude conclude VB cord-010092-uftc8inx 9399 31 if if IN cord-010092-uftc8inx 9399 32 it -PRON- PRP cord-010092-uftc8inx 9399 33 was be VBD cord-010092-uftc8inx 9399 34 the the DT cord-010092-uftc8inx 9399 35 cause cause NN cord-010092-uftc8inx 9399 36 of of IN cord-010092-uftc8inx 9399 37 the the DT cord-010092-uftc8inx 9399 38 DHTR DHTR NNP cord-010092-uftc8inx 9399 39 . . . cord-010092-uftc8inx 9400 1 Nevertheless nevertheless RB cord-010092-uftc8inx 9400 2 , , , cord-010092-uftc8inx 9400 3 Jk(a Jk(a NNP cord-010092-uftc8inx 9400 4 - - HYPH cord-010092-uftc8inx 9400 5 b+ b+ NNP cord-010092-uftc8inx 9400 6 ) ) -RRB- cord-010092-uftc8inx 9400 7 blood blood NN cord-010092-uftc8inx 9400 8 was be VBD cord-010092-uftc8inx 9400 9 issued issue VBN cord-010092-uftc8inx 9400 10 , , , cord-010092-uftc8inx 9400 11 and and CC cord-010092-uftc8inx 9400 12 no no DT cord-010092-uftc8inx 9400 13 adverse adverse JJ cord-010092-uftc8inx 9400 14 events event NNS cord-010092-uftc8inx 9400 15 have have VBP cord-010092-uftc8inx 9400 16 been be VBN cord-010092-uftc8inx 9400 17 reported report VBN cord-010092-uftc8inx 9400 18 . . . cord-010092-uftc8inx 9401 1 Luckily luckily RB cord-010092-uftc8inx 9401 2 , , , cord-010092-uftc8inx 9401 3 the the DT cord-010092-uftc8inx 9401 4 patient patient NN cord-010092-uftc8inx 9401 5 's 's POS cord-010092-uftc8inx 9401 6 bone bone NN cord-010092-uftc8inx 9401 7 marrow marrow NN cord-010092-uftc8inx 9401 8 donor donor NN cord-010092-uftc8inx 9401 9 harbors harbor VBZ cord-010092-uftc8inx 9401 10 the the DT cord-010092-uftc8inx 9401 11 same same JJ cord-010092-uftc8inx 9401 12 variant variant NN cord-010092-uftc8inx 9401 13 allele allele NN cord-010092-uftc8inx 9401 14 . . . cord-010092-uftc8inx 9402 1 Background background NN cord-010092-uftc8inx 9402 2 : : : cord-010092-uftc8inx 9403 1 According accord VBG cord-010092-uftc8inx 9403 2 to to IN cord-010092-uftc8inx 9403 3 the the DT cord-010092-uftc8inx 9403 4 AABB AABB NNP cord-010092-uftc8inx 9403 5 , , , cord-010092-uftc8inx 9403 6 a a DT cord-010092-uftc8inx 9403 7 pre pre JJ cord-010092-uftc8inx 9403 8 - - JJ cord-010092-uftc8inx 9403 9 transfusion transfusion JJ cord-010092-uftc8inx 9403 10 sample sample NN cord-010092-uftc8inx 9403 11 must must MD cord-010092-uftc8inx 9403 12 be be VB cord-010092-uftc8inx 9403 13 obtained obtain VBN cord-010092-uftc8inx 9403 14 within within IN cord-010092-uftc8inx 9403 15 3 3 CD cord-010092-uftc8inx 9403 16 days day NNS cord-010092-uftc8inx 9403 17 of of IN cord-010092-uftc8inx 9403 18 transfusion transfusion NN cord-010092-uftc8inx 9403 19 if if IN cord-010092-uftc8inx 9403 20 a a DT cord-010092-uftc8inx 9403 21 patient patient NN cord-010092-uftc8inx 9403 22 has have VBZ cord-010092-uftc8inx 9403 23 been be VBN cord-010092-uftc8inx 9403 24 transfused transfuse VBN cord-010092-uftc8inx 9403 25 or or CC cord-010092-uftc8inx 9403 26 pregnant pregnant JJ cord-010092-uftc8inx 9403 27 in in IN cord-010092-uftc8inx 9403 28 the the DT cord-010092-uftc8inx 9403 29 preceding precede VBG cord-010092-uftc8inx 9403 30 3 3 CD cord-010092-uftc8inx 9403 31 months month NNS cord-010092-uftc8inx 9403 32 . . . cord-010092-uftc8inx 9404 1 Despite despite IN cord-010092-uftc8inx 9404 2 this this DT cord-010092-uftc8inx 9404 3 safeguard safeguard NN cord-010092-uftc8inx 9404 4 , , , cord-010092-uftc8inx 9404 5 high high JJ cord-010092-uftc8inx 9404 6 risk risk NN cord-010092-uftc8inx 9404 7 patients patient NNS cord-010092-uftc8inx 9404 8 ( ( -LRB- cord-010092-uftc8inx 9404 9 i.e. i.e. FW cord-010092-uftc8inx 9404 10 those those DT cord-010092-uftc8inx 9404 11 recently recently RB cord-010092-uftc8inx 9404 12 transfused transfuse VBN cord-010092-uftc8inx 9404 13 with with IN cord-010092-uftc8inx 9404 14 a a DT cord-010092-uftc8inx 9404 15 history history NN cord-010092-uftc8inx 9404 16 of of IN cord-010092-uftc8inx 9404 17 pregnancy pregnancy NN cord-010092-uftc8inx 9404 18 or or CC cord-010092-uftc8inx 9404 19 transfusion transfusion NN cord-010092-uftc8inx 9404 20 ) ) -RRB- cord-010092-uftc8inx 9404 21 may may MD cord-010092-uftc8inx 9404 22 develop develop VB cord-010092-uftc8inx 9404 23 antibody antibody NN cord-010092-uftc8inx 9404 24 during during IN cord-010092-uftc8inx 9404 25 this this DT cord-010092-uftc8inx 9404 26 3 3 CD cord-010092-uftc8inx 9404 27 day day NN cord-010092-uftc8inx 9404 28 window window NN cord-010092-uftc8inx 9404 29 . . . cord-010092-uftc8inx 9405 1 To to TO cord-010092-uftc8inx 9405 2 avoid avoid VB cord-010092-uftc8inx 9405 3 issuing issue VBG cord-010092-uftc8inx 9405 4 incompatible incompatible JJ cord-010092-uftc8inx 9405 5 red red JJ cord-010092-uftc8inx 9405 6 blood blood NN cord-010092-uftc8inx 9405 7 cells cell NNS cord-010092-uftc8inx 9405 8 ( ( -LRB- cord-010092-uftc8inx 9405 9 RBCs rbc NNS cord-010092-uftc8inx 9405 10 ) ) -RRB- cord-010092-uftc8inx 9405 11 to to IN cord-010092-uftc8inx 9405 12 these these DT cord-010092-uftc8inx 9405 13 patients patient NNS cord-010092-uftc8inx 9405 14 , , , cord-010092-uftc8inx 9405 15 a a DT cord-010092-uftc8inx 9405 16 new new JJ cord-010092-uftc8inx 9405 17 antibody antibody NN cord-010092-uftc8inx 9405 18 screen screen NN cord-010092-uftc8inx 9405 19 ( ( -LRB- cord-010092-uftc8inx 9405 20 ABS abs NN cord-010092-uftc8inx 9405 21 ) ) -RRB- cord-010092-uftc8inx 9405 22 sample sample NN cord-010092-uftc8inx 9405 23 should should MD cord-010092-uftc8inx 9405 24 be be VB cord-010092-uftc8inx 9405 25 drawn draw VBN cord-010092-uftc8inx 9405 26 and and CC cord-010092-uftc8inx 9405 27 tested test VBN cord-010092-uftc8inx 9405 28 shortly shortly RB cord-010092-uftc8inx 9405 29 before before IN cord-010092-uftc8inx 9405 30 anticipated anticipate VBN cord-010092-uftc8inx 9405 31 transfusion transfusion NN cord-010092-uftc8inx 9405 32 . . . cord-010092-uftc8inx 9406 1 Aims aim VBZ cord-010092-uftc8inx 9406 2 : : : cord-010092-uftc8inx 9406 3 We -PRON- PRP cord-010092-uftc8inx 9406 4 report report VBP cord-010092-uftc8inx 9406 5 a a DT cord-010092-uftc8inx 9406 6 case case NN cord-010092-uftc8inx 9406 7 of of IN cord-010092-uftc8inx 9406 8 a a DT cord-010092-uftc8inx 9406 9 60 60 CD cord-010092-uftc8inx 9406 10 y y NN cord-010092-uftc8inx 9406 11 / / SYM cord-010092-uftc8inx 9406 12 o o NN cord-010092-uftc8inx 9406 13 man man NN cord-010092-uftc8inx 9406 14 who who WP cord-010092-uftc8inx 9406 15 presented present VBD cord-010092-uftc8inx 9406 16 to to IN cord-010092-uftc8inx 9406 17 the the DT cord-010092-uftc8inx 9406 18 ED ED NNP cord-010092-uftc8inx 9406 19 ( ( -LRB- cord-010092-uftc8inx 9406 20 hospital hospital NN cord-010092-uftc8inx 9406 21 day day NN cord-010092-uftc8inx 9406 22 0 0 NFP cord-010092-uftc8inx 9406 23 , , , cord-010092-uftc8inx 9406 24 HD0 hd0 NN cord-010092-uftc8inx 9406 25 ) ) -RRB- cord-010092-uftc8inx 9406 26 with with IN cord-010092-uftc8inx 9406 27 a a DT cord-010092-uftc8inx 9406 28 post post JJ cord-010092-uftc8inx 9406 29 - - JJ cord-010092-uftc8inx 9406 30 fall fall JJ cord-010092-uftc8inx 9406 31 intracranial intracranial JJ cord-010092-uftc8inx 9406 32 hemorrhage hemorrhage NN cord-010092-uftc8inx 9406 33 and and CC cord-010092-uftc8inx 9406 34 multiple multiple JJ cord-010092-uftc8inx 9406 35 fractures fracture NNS cord-010092-uftc8inx 9406 36 . . . cord-010092-uftc8inx 9407 1 Anti Anti NNP cord-010092-uftc8inx 9407 2 - - NN cord-010092-uftc8inx 9407 3 E e JJ cord-010092-uftc8inx 9407 4 and and CC cord-010092-uftc8inx 9407 5 anti anti JJ cord-010092-uftc8inx 9407 6 - - NN cord-010092-uftc8inx 9407 7 Jka Jka NNP cord-010092-uftc8inx 9407 8 were be VBD cord-010092-uftc8inx 9407 9 identified identify VBN cord-010092-uftc8inx 9407 10 after after IN cord-010092-uftc8inx 9407 11 admission admission NN cord-010092-uftc8inx 9407 12 on on IN cord-010092-uftc8inx 9407 13 a a DT cord-010092-uftc8inx 9407 14 new new JJ cord-010092-uftc8inx 9407 15 specimen specimen NN cord-010092-uftc8inx 9407 16 prior prior RB cord-010092-uftc8inx 9407 17 to to IN cord-010092-uftc8inx 9407 18 current current JJ cord-010092-uftc8inx 9407 19 specimen specimen NN cord-010092-uftc8inx 9407 20 expiration expiration NN cord-010092-uftc8inx 9407 21 ( ( -LRB- cord-010092-uftc8inx 9407 22 <3 <3 NNP cord-010092-uftc8inx 9407 23 days day NNS cord-010092-uftc8inx 9407 24 ) ) -RRB- cord-010092-uftc8inx 9407 25 . . . cord-010092-uftc8inx 9408 1 Methods method NNS cord-010092-uftc8inx 9408 2 : : : cord-010092-uftc8inx 9409 1 Specimen specimen JJ cord-010092-uftc8inx 9409 2 # # NN cord-010092-uftc8inx 9409 3 1 1 CD cord-010092-uftc8inx 9409 4 ( ( -LRB- cord-010092-uftc8inx 9409 5 S1 S1 NNP cord-010092-uftc8inx 9409 6 ) ) -RRB- cord-010092-uftc8inx 9409 7 was be VBD cord-010092-uftc8inx 9409 8 sent send VBN cord-010092-uftc8inx 9409 9 on on IN cord-010092-uftc8inx 9409 10 HD0 HD0 NNP cord-010092-uftc8inx 9409 11 for for IN cord-010092-uftc8inx 9409 12 Type Type NNP cord-010092-uftc8inx 9409 13 & & CC cord-010092-uftc8inx 9409 14 ABS ABS NNP cord-010092-uftc8inx 9409 15 ( ( -LRB- cord-010092-uftc8inx 9409 16 T&S T&S NNP cord-010092-uftc8inx 9409 17 ) ) -RRB- cord-010092-uftc8inx 9409 18 and and CC cord-010092-uftc8inx 9409 19 crossmatch crossmatch NN cord-010092-uftc8inx 9409 20 ( ( -LRB- cord-010092-uftc8inx 9409 21 XM XM NNP cord-010092-uftc8inx 9409 22 ) ) -RRB- cord-010092-uftc8inx 9409 23 of of IN cord-010092-uftc8inx 9409 24 2 2 CD cord-010092-uftc8inx 9409 25 RBCs rbc NNS cord-010092-uftc8inx 9409 26 . . . cord-010092-uftc8inx 9410 1 ABS abs NN cord-010092-uftc8inx 9410 2 and and CC cord-010092-uftc8inx 9410 3 immediate immediate JJ cord-010092-uftc8inx 9410 4 spin spin NN cord-010092-uftc8inx 9410 5 XM XM NNP cord-010092-uftc8inx 9410 6 were be VBD cord-010092-uftc8inx 9410 7 negative negative JJ cord-010092-uftc8inx 9410 8 ; ; : cord-010092-uftc8inx 9410 9 there there EX cord-010092-uftc8inx 9410 10 was be VBD cord-010092-uftc8inx 9410 11 no no DT cord-010092-uftc8inx 9410 12 patient patient JJ cord-010092-uftc8inx 9410 13 history history NN cord-010092-uftc8inx 9410 14 . . . cord-010092-uftc8inx 9411 1 By by IN cord-010092-uftc8inx 9411 2 HD9 HD9 NNP cord-010092-uftc8inx 9411 3 , , , cord-010092-uftc8inx 9411 4 he -PRON- PRP cord-010092-uftc8inx 9411 5 had have VBD cord-010092-uftc8inx 9411 6 4 4 CD cord-010092-uftc8inx 9411 7 negative negative JJ cord-010092-uftc8inx 9411 8 T&S t&s NN cord-010092-uftc8inx 9411 9 specimens specimen NNS cord-010092-uftc8inx 9411 10 ( ( -LRB- cord-010092-uftc8inx 9411 11 HD0 hd0 NN cord-010092-uftc8inx 9411 12 : : : cord-010092-uftc8inx 9411 13 S1 S1 NNP cord-010092-uftc8inx 9411 14 ; ; : cord-010092-uftc8inx 9411 15 HD2 HD2 NNP cord-010092-uftc8inx 9411 16 : : : cord-010092-uftc8inx 9411 17 S2&3 s2&3 RBS cord-010092-uftc8inx 9411 18 ; ; : cord-010092-uftc8inx 9411 19 HD6 hd6 NN cord-010092-uftc8inx 9411 20 : : : cord-010092-uftc8inx 9411 21 S4 S4 NNP cord-010092-uftc8inx 9411 22 ) ) -RRB- cord-010092-uftc8inx 9411 23 and and CC cord-010092-uftc8inx 9411 24 had have VBD cord-010092-uftc8inx 9411 25 been be VBN cord-010092-uftc8inx 9411 26 transfused transfuse VBN cord-010092-uftc8inx 9411 27 4 4 CD cord-010092-uftc8inx 9411 28 RBCs rbc NNS cord-010092-uftc8inx 9411 29 ( ( -LRB- cord-010092-uftc8inx 9411 30 HD2 HD2 NNP cord-010092-uftc8inx 9411 31 : : : cord-010092-uftc8inx 9411 32 2 2 CD cord-010092-uftc8inx 9411 33 ; ; : cord-010092-uftc8inx 9411 34 HD5 hd5 NN cord-010092-uftc8inx 9411 35 : : : cord-010092-uftc8inx 9411 36 2 2 LS cord-010092-uftc8inx 9411 37 ) ) -RRB- cord-010092-uftc8inx 9412 1 via via IN cord-010092-uftc8inx 9412 2 electronic electronic JJ cord-010092-uftc8inx 9412 3 XM XM NNP cord-010092-uftc8inx 9412 4 ( ( -LRB- cord-010092-uftc8inx 9412 5 EXM EXM NNP cord-010092-uftc8inx 9412 6 ) ) -RRB- cord-010092-uftc8inx 9412 7 . . . cord-010092-uftc8inx 9413 1 At at IN cord-010092-uftc8inx 9413 2 1730 1730 CD cord-010092-uftc8inx 9413 3 hr hr NN cord-010092-uftc8inx 9413 4 on on IN cord-010092-uftc8inx 9413 5 HD9 HD9 NNP cord-010092-uftc8inx 9413 6 , , , cord-010092-uftc8inx 9413 7 2 2 CD cord-010092-uftc8inx 9413 8 RBCs rbc NNS cord-010092-uftc8inx 9413 9 were be VBD cord-010092-uftc8inx 9413 10 requested request VBN cord-010092-uftc8inx 9413 11 and and CC cord-010092-uftc8inx 9413 12 could could MD cord-010092-uftc8inx 9413 13 have have VB cord-010092-uftc8inx 9413 14 been be VBN cord-010092-uftc8inx 9413 15 issued issue VBN cord-010092-uftc8inx 9413 16 via via IN cord-010092-uftc8inx 9413 17 EXM EXM NNP cord-010092-uftc8inx 9413 18 since since IN cord-010092-uftc8inx 9413 19 S4 S4 NNP cord-010092-uftc8inx 9413 20 was be VBD cord-010092-uftc8inx 9413 21 not not RB cord-010092-uftc8inx 9413 22 expiring expire VBG cord-010092-uftc8inx 9413 23 until until IN cord-010092-uftc8inx 9413 24 midnight midnight NN cord-010092-uftc8inx 9413 25 . . . cord-010092-uftc8inx 9414 1 However however RB cord-010092-uftc8inx 9414 2 , , , cord-010092-uftc8inx 9414 3 given give VBN cord-010092-uftc8inx 9414 4 recent recent JJ cord-010092-uftc8inx 9414 5 transfusions transfusion NNS cord-010092-uftc8inx 9414 6 , , , cord-010092-uftc8inx 9414 7 BB BB NNP cord-010092-uftc8inx 9414 8 staff staff NN cord-010092-uftc8inx 9414 9 first first RB cord-010092-uftc8inx 9414 10 called call VBD cord-010092-uftc8inx 9414 11 the the DT cord-010092-uftc8inx 9414 12 patient patient NN cord-010092-uftc8inx 9414 13 's 's POS cord-010092-uftc8inx 9414 14 nurse nurse NN cord-010092-uftc8inx 9414 15 to to TO cord-010092-uftc8inx 9414 16 review review VB cord-010092-uftc8inx 9414 17 history history NN cord-010092-uftc8inx 9414 18 . . . cord-010092-uftc8inx 9415 1 Patient Patient NNP cord-010092-uftc8inx 9415 2 was be VBD cord-010092-uftc8inx 9415 3 uncommunicative uncommunicative JJ cord-010092-uftc8inx 9415 4 , , , cord-010092-uftc8inx 9415 5 but but CC cord-010092-uftc8inx 9415 6 had have VBD cord-010092-uftc8inx 9415 7 scars scar NNS cord-010092-uftc8inx 9415 8 suggesting suggest VBG cord-010092-uftc8inx 9415 9 past past IN cord-010092-uftc8inx 9415 10 trauma trauma NN cord-010092-uftc8inx 9415 11 or or CC cord-010092-uftc8inx 9415 12 surgery surgery NN cord-010092-uftc8inx 9415 13 . . . cord-010092-uftc8inx 9416 1 S5 S5 NNP cord-010092-uftc8inx 9416 2 was be VBD cord-010092-uftc8inx 9416 3 requested request VBN cord-010092-uftc8inx 9416 4 and and CC cord-010092-uftc8inx 9416 5 received receive VBN cord-010092-uftc8inx 9416 6 at at IN cord-010092-uftc8inx 9416 7 1801 1801 CD cord-010092-uftc8inx 9416 8 hr hr NN cord-010092-uftc8inx 9416 9 . . . cord-010092-uftc8inx 9417 1 Results result NNS cord-010092-uftc8inx 9417 2 : : : cord-010092-uftc8inx 9417 3 S5 S5 NNP cord-010092-uftc8inx 9417 4 showed show VBD cord-010092-uftc8inx 9417 5 anti anti JJ cord-010092-uftc8inx 9417 6 - - JJ cord-010092-uftc8inx 9417 7 E e JJ cord-010092-uftc8inx 9417 8 and and CC cord-010092-uftc8inx 9417 9 anti anti JJ cord-010092-uftc8inx 9417 10 - - NN cord-010092-uftc8inx 9417 11 Jk Jk NNP cord-010092-uftc8inx 9417 12 a a DT cord-010092-uftc8inx 9417 13 in in IN cord-010092-uftc8inx 9417 14 plasma plasma NN cord-010092-uftc8inx 9417 15 and and CC cord-010092-uftc8inx 9417 16 eluate eluate NN cord-010092-uftc8inx 9417 17 . . . cord-010092-uftc8inx 9418 1 His -PRON- PRP$ cord-010092-uftc8inx 9418 2 hemoglobin hemoglobin NN cord-010092-uftc8inx 9418 3 / / SYM cord-010092-uftc8inx 9418 4 hematocrit hematocrit NN cord-010092-uftc8inx 9418 5 ( ( -LRB- cord-010092-uftc8inx 9418 6 H h NN cord-010092-uftc8inx 9418 7 / / SYM cord-010092-uftc8inx 9418 8 H H NNP cord-010092-uftc8inx 9418 9 ) ) -RRB- cord-010092-uftc8inx 9418 10 decreased decrease VBD cord-010092-uftc8inx 9418 11 from from IN cord-010092-uftc8inx 9418 12 10.2 10.2 CD cord-010092-uftc8inx 9418 13 ( ( -LRB- cord-010092-uftc8inx 9418 14 14.0 14.0 CD cord-010092-uftc8inx 9418 15 - - SYM cord-010092-uftc8inx 9418 16 17.5 17.5 CD cord-010092-uftc8inx 9418 17 g g NN cord-010092-uftc8inx 9418 18 / / SYM cord-010092-uftc8inx 9418 19 dL)/30.1 dl)/30.1 NN cord-010092-uftc8inx 9418 20 ( ( -LRB- cord-010092-uftc8inx 9418 21 41.5 41.5 CD cord-010092-uftc8inx 9418 22 - - SYM cord-010092-uftc8inx 9418 23 50.4 50.4 CD cord-010092-uftc8inx 9418 24 % % NN cord-010092-uftc8inx 9418 25 ) ) -RRB- cord-010092-uftc8inx 9418 26 on on IN cord-010092-uftc8inx 9418 27 HD6 HD6 NNP cord-010092-uftc8inx 9418 28 to to IN cord-010092-uftc8inx 9418 29 6.9/ 6.9/ CD cord-010092-uftc8inx 9418 30 20.6 20.6 CD cord-010092-uftc8inx 9418 31 on on IN cord-010092-uftc8inx 9418 32 HD9 HD9 NNP cord-010092-uftc8inx 9418 33 . . . cord-010092-uftc8inx 9419 1 During during IN cord-010092-uftc8inx 9419 2 this this DT cord-010092-uftc8inx 9419 3 period period NN cord-010092-uftc8inx 9419 4 , , , cord-010092-uftc8inx 9419 5 he -PRON- PRP cord-010092-uftc8inx 9419 6 underwent undergo VBD cord-010092-uftc8inx 9419 7 several several JJ cord-010092-uftc8inx 9419 8 surgeries surgery NNS cord-010092-uftc8inx 9419 9 without without IN cord-010092-uftc8inx 9419 10 unexpected unexpected JJ cord-010092-uftc8inx 9419 11 bleeding bleeding NN cord-010092-uftc8inx 9419 12 , , , cord-010092-uftc8inx 9419 13 documented document VBN cord-010092-uftc8inx 9419 14 jaundice jaundice NN cord-010092-uftc8inx 9419 15 or or CC cord-010092-uftc8inx 9419 16 dark dark JJ cord-010092-uftc8inx 9419 17 urine urine NN cord-010092-uftc8inx 9419 18 . . . cord-010092-uftc8inx 9420 1 Two two CD cord-010092-uftc8inx 9420 2 E e NN cord-010092-uftc8inx 9420 3 - - NN cord-010092-uftc8inx 9420 4 Jk(a- jk(a- JJ cord-010092-uftc8inx 9420 5 ) ) -RRB- cord-010092-uftc8inx 9420 6 RBCs rbc NNS cord-010092-uftc8inx 9420 7 were be VBD cord-010092-uftc8inx 9420 8 transfused transfuse VBN cord-010092-uftc8inx 9420 9 on on IN cord-010092-uftc8inx 9420 10 HD9 HD9 NNP cord-010092-uftc8inx 9420 11 , , , cord-010092-uftc8inx 9420 12 which which WDT cord-010092-uftc8inx 9420 13 he -PRON- PRP cord-010092-uftc8inx 9420 14 tolerated tolerate VBD cord-010092-uftc8inx 9420 15 well well RB cord-010092-uftc8inx 9420 16 with with IN cord-010092-uftc8inx 9420 17 an an DT cord-010092-uftc8inx 9420 18 increase increase NN cord-010092-uftc8inx 9420 19 of of IN cord-010092-uftc8inx 9420 20 hemoglobin hemoglobin NN cord-010092-uftc8inx 9420 21 from from IN cord-010092-uftc8inx 9420 22 6.9 6.9 CD cord-010092-uftc8inx 9420 23 g g NN cord-010092-uftc8inx 9420 24 / / SYM cord-010092-uftc8inx 9420 25 dL dl NN cord-010092-uftc8inx 9420 26 to to IN cord-010092-uftc8inx 9420 27 8.6 8.6 CD cord-010092-uftc8inx 9420 28 g/ g/ NNS cord-010092-uftc8inx 9421 1 dL. dL. NNP cord-010092-uftc8inx 9422 1 He -PRON- PRP cord-010092-uftc8inx 9422 2 did do VBD cord-010092-uftc8inx 9422 3 well well RB cord-010092-uftc8inx 9422 4 post post VB cord-010092-uftc8inx 9422 5 transfusion transfusion NN cord-010092-uftc8inx 9422 6 with with IN cord-010092-uftc8inx 9422 7 stable stable JJ cord-010092-uftc8inx 9422 8 H h NN cord-010092-uftc8inx 9422 9 / / SYM cord-010092-uftc8inx 9422 10 H h NN cord-010092-uftc8inx 9422 11 between between IN cord-010092-uftc8inx 9422 12 8.1/24.2.0 8.1/24.2.0 CD cord-010092-uftc8inx 9422 13 to to IN cord-010092-uftc8inx 9422 14 8.5/25.3 8.5/25.3 CD cord-010092-uftc8inx 9422 15 . . . cord-010092-uftc8inx 9423 1 He -PRON- PRP cord-010092-uftc8inx 9423 2 was be VBD cord-010092-uftc8inx 9423 3 discharged discharge VBN cord-010092-uftc8inx 9423 4 on on IN cord-010092-uftc8inx 9423 5 HD19 HD19 NNP cord-010092-uftc8inx 9423 6 . . . cord-010092-uftc8inx 9424 1 Repeat repeat VB cord-010092-uftc8inx 9424 2 ABS abs NN cord-010092-uftc8inx 9424 3 on on IN cord-010092-uftc8inx 9424 4 S4 S4 NNP cord-010092-uftc8inx 9424 5 was be VBD cord-010092-uftc8inx 9424 6 negative negative JJ cord-010092-uftc8inx 9424 7 . . . cord-010092-uftc8inx 9425 1 Of of IN cord-010092-uftc8inx 9425 2 the the DT cord-010092-uftc8inx 9425 3 4 4 CD cord-010092-uftc8inx 9425 4 RBCs rbc NNS cord-010092-uftc8inx 9425 5 transfused transfuse VBN cord-010092-uftc8inx 9425 6 before before IN cord-010092-uftc8inx 9425 7 S5 S5 NNP cord-010092-uftc8inx 9425 8 , , , cord-010092-uftc8inx 9425 9 one one CD cord-010092-uftc8inx 9425 10 was be VBD cord-010092-uftc8inx 9425 11 E+ E+ NNP cord-010092-uftc8inx 9425 12 and and CC cord-010092-uftc8inx 9425 13 four four CD cord-010092-uftc8inx 9425 14 Jk(a+ Jk(a+ NNP cord-010092-uftc8inx 9425 15 ) ) -RRB- cord-010092-uftc8inx 9425 16 . . . cord-010092-uftc8inx 9426 1 The the DT cord-010092-uftc8inx 9426 2 family family NN cord-010092-uftc8inx 9426 3 reported report VBD cord-010092-uftc8inx 9426 4 that that IN cord-010092-uftc8inx 9426 5 he -PRON- PRP cord-010092-uftc8inx 9426 6 was be VBD cord-010092-uftc8inx 9426 7 injured injure VBN cord-010092-uftc8inx 9426 8 20 20 CD cord-010092-uftc8inx 9426 9 years year NNS cord-010092-uftc8inx 9426 10 prior prior RB cord-010092-uftc8inx 9426 11 and and CC cord-010092-uftc8inx 9426 12 had have VBD cord-010092-uftc8inx 9426 13 been be VBN cord-010092-uftc8inx 9426 14 admitted admit VBN cord-010092-uftc8inx 9426 15 to to IN cord-010092-uftc8inx 9426 16 3 3 CD cord-010092-uftc8inx 9426 17 hospitals hospital NNS cord-010092-uftc8inx 9426 18 , , , cord-010092-uftc8inx 9426 19 but but CC cord-010092-uftc8inx 9426 20 was be VBD cord-010092-uftc8inx 9426 21 unaware unaware JJ cord-010092-uftc8inx 9426 22 of of IN cord-010092-uftc8inx 9426 23 transfusion transfusion NN cord-010092-uftc8inx 9426 24 . . . cord-010092-uftc8inx 9427 1 Hospital hospital NN cord-010092-uftc8inx 9427 2 # # NN cord-010092-uftc8inx 9427 3 1 1 CD cord-010092-uftc8inx 9427 4 ( ( -LRB- cord-010092-uftc8inx 9427 5 H1 H1 NNP cord-010092-uftc8inx 9427 6 ) ) -RRB- cord-010092-uftc8inx 9427 7 reported report VBD cord-010092-uftc8inx 9427 8 admissions admission NNS cord-010092-uftc8inx 9427 9 20 20 CD cord-010092-uftc8inx 9427 10 years year NNS cord-010092-uftc8inx 9427 11 ago ago RB cord-010092-uftc8inx 9427 12 ( ( -LRB- cord-010092-uftc8inx 9427 13 2 2 CD cord-010092-uftc8inx 9427 14 RBCs rbc NNS cord-010092-uftc8inx 9427 15 transfused transfuse VBN cord-010092-uftc8inx 9427 16 ) ) -RRB- cord-010092-uftc8inx 9427 17 and and CC cord-010092-uftc8inx 9427 18 4 4 CD cord-010092-uftc8inx 9427 19 years year NNS cord-010092-uftc8inx 9427 20 ago ago RB cord-010092-uftc8inx 9427 21 ; ; : cord-010092-uftc8inx 9427 22 all all DT cord-010092-uftc8inx 9427 23 ABS abs NN cord-010092-uftc8inx 9427 24 were be VBD cord-010092-uftc8inx 9427 25 negative negative JJ cord-010092-uftc8inx 9427 26 . . . cord-010092-uftc8inx 9428 1 H2 H2 NNP cord-010092-uftc8inx 9428 2 admission admission NN cord-010092-uftc8inx 9428 3 was be VBD cord-010092-uftc8inx 9428 4 5 5 CD cord-010092-uftc8inx 9428 5 years year NNS cord-010092-uftc8inx 9428 6 ago ago RB cord-010092-uftc8inx 9428 7 with with IN cord-010092-uftc8inx 9428 8 positive positive JJ cord-010092-uftc8inx 9428 9 ABS abs NN cord-010092-uftc8inx 9428 10 and and CC cord-010092-uftc8inx 9428 11 inconclusive inconclusive JJ cord-010092-uftc8inx 9428 12 workup workup NN cord-010092-uftc8inx 9428 13 . . . cord-010092-uftc8inx 9429 1 H3 H3 NNP cord-010092-uftc8inx 9429 2 admission admission NN cord-010092-uftc8inx 9429 3 4 4 CD cord-010092-uftc8inx 9429 4 years year NNS cord-010092-uftc8inx 9429 5 ago ago RB cord-010092-uftc8inx 9429 6 showed show VBD cord-010092-uftc8inx 9429 7 negative negative JJ cord-010092-uftc8inx 9429 8 ABS abs NN cord-010092-uftc8inx 9429 9 . . . cord-010092-uftc8inx 9430 1 Summary Summary NNP cord-010092-uftc8inx 9430 2 / / SYM cord-010092-uftc8inx 9430 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 9430 4 : : : cord-010092-uftc8inx 9431 1 The the DT cord-010092-uftc8inx 9431 2 patient patient NN cord-010092-uftc8inx 9431 3 developed develop VBD cord-010092-uftc8inx 9431 4 a a DT cord-010092-uftc8inx 9431 5 significant significant JJ cord-010092-uftc8inx 9431 6 antibody antibody NN cord-010092-uftc8inx 9431 7 response response NN cord-010092-uftc8inx 9431 8 in in IN cord-010092-uftc8inx 9431 9 less less JJR cord-010092-uftc8inx 9431 10 than than IN cord-010092-uftc8inx 9431 11 3 3 CD cord-010092-uftc8inx 9431 12 days day NNS cord-010092-uftc8inx 9431 13 from from IN cord-010092-uftc8inx 9431 14 the the DT cord-010092-uftc8inx 9431 15 specimen specimen JJ cord-010092-uftc8inx 9431 16 collection collection NN cord-010092-uftc8inx 9431 17 , , , cord-010092-uftc8inx 9431 18 likely likely RB cord-010092-uftc8inx 9431 19 a a DT cord-010092-uftc8inx 9431 20 secondary secondary JJ cord-010092-uftc8inx 9431 21 immune immune JJ cord-010092-uftc8inx 9431 22 response response NN cord-010092-uftc8inx 9431 23 to to IN cord-010092-uftc8inx 9431 24 sensitization sensitization NN cord-010092-uftc8inx 9431 25 from from IN cord-010092-uftc8inx 9431 26 a a DT cord-010092-uftc8inx 9431 27 transfusion transfusion NN cord-010092-uftc8inx 9431 28 20 20 CD cord-010092-uftc8inx 9431 29 years year NNS cord-010092-uftc8inx 9431 30 earlier early RBR cord-010092-uftc8inx 9431 31 . . . cord-010092-uftc8inx 9432 1 A a DT cord-010092-uftc8inx 9432 2 new new JJ cord-010092-uftc8inx 9432 3 specimen specimen NN cord-010092-uftc8inx 9432 4 was be VBD cord-010092-uftc8inx 9432 5 requested request VBN cord-010092-uftc8inx 9432 6 prior prior RB cord-010092-uftc8inx 9432 7 to to IN cord-010092-uftc8inx 9432 8 transfusion transfusion NN cord-010092-uftc8inx 9432 9 even even RB cord-010092-uftc8inx 9432 10 though though IN cord-010092-uftc8inx 9432 11 the the DT cord-010092-uftc8inx 9432 12 existing exist VBG cord-010092-uftc8inx 9432 13 sample sample NN cord-010092-uftc8inx 9432 14 ( ( -LRB- cord-010092-uftc8inx 9432 15 which which WDT cord-010092-uftc8inx 9432 16 was be VBD cord-010092-uftc8inx 9432 17 ABS ABS NNP cord-010092-uftc8inx 9432 18 Negative negative JJ cord-010092-uftc8inx 9432 19 ) ) -RRB- cord-010092-uftc8inx 9432 20 had have VBD cord-010092-uftc8inx 9432 21 not not RB cord-010092-uftc8inx 9432 22 expired expire VBN cord-010092-uftc8inx 9432 23 . . . cord-010092-uftc8inx 9433 1 This this DT cord-010092-uftc8inx 9433 2 approach approach NN cord-010092-uftc8inx 9433 3 identified identify VBD cord-010092-uftc8inx 9433 4 new new JJ cord-010092-uftc8inx 9433 5 antibodies antibody NNS cord-010092-uftc8inx 9433 6 , , , cord-010092-uftc8inx 9433 7 preventing prevent VBG cord-010092-uftc8inx 9433 8 transfusion transfusion NN cord-010092-uftc8inx 9433 9 of of IN cord-010092-uftc8inx 9433 10 incompatible incompatible JJ cord-010092-uftc8inx 9433 11 RBCs rbc NNS cord-010092-uftc8inx 9433 12 , , , cord-010092-uftc8inx 9433 13 and and CC cord-010092-uftc8inx 9433 14 a a DT cord-010092-uftc8inx 9433 15 potentially potentially RB cord-010092-uftc8inx 9433 16 serious serious JJ cord-010092-uftc8inx 9433 17 hemolytic hemolytic JJ cord-010092-uftc8inx 9433 18 transfusion transfusion NN cord-010092-uftc8inx 9433 19 reaction reaction NN cord-010092-uftc8inx 9433 20 . . . cord-010092-uftc8inx 9434 1 This this DT cord-010092-uftc8inx 9434 2 case case NN cord-010092-uftc8inx 9434 3 suggests suggest VBZ cord-010092-uftc8inx 9434 4 that that IN cord-010092-uftc8inx 9434 5 for for IN cord-010092-uftc8inx 9434 6 high high JJ cord-010092-uftc8inx 9434 7 - - HYPH cord-010092-uftc8inx 9434 8 risk risk NN cord-010092-uftc8inx 9434 9 patients patient NNS cord-010092-uftc8inx 9434 10 , , , cord-010092-uftc8inx 9434 11 ABS abs VB cord-010092-uftc8inx 9434 12 more more RBR cord-010092-uftc8inx 9434 13 frequently frequently RB cord-010092-uftc8inx 9434 14 than than IN cord-010092-uftc8inx 9434 15 every every DT cord-010092-uftc8inx 9434 16 3 3 CD cord-010092-uftc8inx 9434 17 days day NNS cord-010092-uftc8inx 9434 18 may may MD cord-010092-uftc8inx 9434 19 be be VB cord-010092-uftc8inx 9434 20 beneficial beneficial JJ cord-010092-uftc8inx 9434 21 . . . cord-010092-uftc8inx 9435 1 It -PRON- PRP cord-010092-uftc8inx 9435 2 is be VBZ cord-010092-uftc8inx 9435 3 important important JJ cord-010092-uftc8inx 9435 4 to to TO cord-010092-uftc8inx 9435 5 increase increase VB cord-010092-uftc8inx 9435 6 clinicians clinician NNS cord-010092-uftc8inx 9435 7 ' ' POS cord-010092-uftc8inx 9435 8 and and CC cord-010092-uftc8inx 9435 9 laboratorians laboratorians NNP cord-010092-uftc8inx 9435 10 ' ' POS cord-010092-uftc8inx 9435 11 awareness awareness NN cord-010092-uftc8inx 9435 12 of of IN cord-010092-uftc8inx 9435 13 this this DT cord-010092-uftc8inx 9435 14 issue issue NN cord-010092-uftc8inx 9435 15 . . . cord-010092-uftc8inx 9436 1 Background background NN cord-010092-uftc8inx 9436 2 : : : cord-010092-uftc8inx 9437 1 Red red JJ cord-010092-uftc8inx 9437 2 cells cell NNS cord-010092-uftc8inx 9437 3 with with IN cord-010092-uftc8inx 9437 4 partial partial JJ cord-010092-uftc8inx 9437 5 D d NN cord-010092-uftc8inx 9437 6 antigen antigen NN cord-010092-uftc8inx 9437 7 have have VBP cord-010092-uftc8inx 9437 8 historically historically RB cord-010092-uftc8inx 9437 9 been be VBN cord-010092-uftc8inx 9437 10 classified classify VBN cord-010092-uftc8inx 9437 11 as as IN cord-010092-uftc8inx 9437 12 such such JJ cord-010092-uftc8inx 9437 13 , , , cord-010092-uftc8inx 9437 14 based base VBN cord-010092-uftc8inx 9437 15 on on IN cord-010092-uftc8inx 9437 16 the the DT cord-010092-uftc8inx 9437 17 fact fact NN cord-010092-uftc8inx 9437 18 that that IN cord-010092-uftc8inx 9437 19 the the DT cord-010092-uftc8inx 9437 20 red red JJ cord-010092-uftc8inx 9437 21 cells cell NNS cord-010092-uftc8inx 9437 22 type type NN cord-010092-uftc8inx 9437 23 as as IN cord-010092-uftc8inx 9437 24 D d NN cord-010092-uftc8inx 9437 25 positive positive JJ cord-010092-uftc8inx 9437 26 , , , cord-010092-uftc8inx 9437 27 but but CC cord-010092-uftc8inx 9437 28 individuals individual NNS cord-010092-uftc8inx 9437 29 make make VBP cord-010092-uftc8inx 9437 30 anti anti JJ cord-010092-uftc8inx 9437 31 - - JJ cord-010092-uftc8inx 9437 32 D d JJ cord-010092-uftc8inx 9437 33 antibody antibody NN cord-010092-uftc8inx 9437 34 when when WRB cord-010092-uftc8inx 9437 35 exposed expose VBN cord-010092-uftc8inx 9437 36 to to IN cord-010092-uftc8inx 9437 37 conventional conventional JJ cord-010092-uftc8inx 9437 38 D d NN cord-010092-uftc8inx 9437 39 antigen antigen NN cord-010092-uftc8inx 9437 40 . . . cord-010092-uftc8inx 9438 1 A a DT cord-010092-uftc8inx 9438 2 definitive definitive JJ cord-010092-uftc8inx 9438 3 confirmation confirmation NN cord-010092-uftc8inx 9438 4 of of IN cord-010092-uftc8inx 9438 5 the the DT cord-010092-uftc8inx 9438 6 variant variant NN cord-010092-uftc8inx 9438 7 of of IN cord-010092-uftc8inx 9438 8 D D NNP cord-010092-uftc8inx 9438 9 antigen antigen NN cord-010092-uftc8inx 9438 10 is be VBZ cord-010092-uftc8inx 9438 11 obtained obtain VBN cord-010092-uftc8inx 9438 12 after after IN cord-010092-uftc8inx 9438 13 the the DT cord-010092-uftc8inx 9438 14 Rh Rh NNP cord-010092-uftc8inx 9438 15 D d NN cord-010092-uftc8inx 9438 16 genotyping genotyping NN cord-010092-uftc8inx 9438 17 . . . cord-010092-uftc8inx 9439 1 Aims aim VBZ cord-010092-uftc8inx 9439 2 : : : cord-010092-uftc8inx 9440 1 To to TO cord-010092-uftc8inx 9440 2 present present VB cord-010092-uftc8inx 9440 3 a a DT cord-010092-uftc8inx 9440 4 case case NN cord-010092-uftc8inx 9440 5 study study NN cord-010092-uftc8inx 9440 6 of of IN cord-010092-uftc8inx 9440 7 the the DT cord-010092-uftc8inx 9440 8 patient patient NN cord-010092-uftc8inx 9440 9 's 's POS cord-010092-uftc8inx 9440 10 alloimmunisation alloimmunisation NN cord-010092-uftc8inx 9440 11 with with IN cord-010092-uftc8inx 9440 12 the the DT cord-010092-uftc8inx 9440 13 present present JJ cord-010092-uftc8inx 9440 14 D d NN cord-010092-uftc8inx 9440 15 partial partial JJ cord-010092-uftc8inx 9440 16 antigen antigen NN cord-010092-uftc8inx 9440 17 type type NN cord-010092-uftc8inx 9440 18 DNB dnb NN cord-010092-uftc8inx 9440 19 , , , cord-010092-uftc8inx 9440 20 most most RBS cord-010092-uftc8inx 9440 21 likely likely JJ cord-010092-uftc8inx 9440 22 on on IN cord-010092-uftc8inx 9440 23 previously previously RB cord-010092-uftc8inx 9440 24 received receive VBN cord-010092-uftc8inx 9440 25 transfusions transfusion NNS cord-010092-uftc8inx 9440 26 . . . cord-010092-uftc8inx 9441 1 Methods method NNS cord-010092-uftc8inx 9441 2 : : : cord-010092-uftc8inx 9441 3 The the DT cord-010092-uftc8inx 9441 4 patient patient NN cord-010092-uftc8inx 9441 5 's 's POS cord-010092-uftc8inx 9441 6 pretransfusion pretransfusion NN cord-010092-uftc8inx 9441 7 testing testing NN cord-010092-uftc8inx 9441 8 included include VBD cord-010092-uftc8inx 9441 9 the the DT cord-010092-uftc8inx 9441 10 determination determination NN cord-010092-uftc8inx 9441 11 of of IN cord-010092-uftc8inx 9441 12 the the DT cord-010092-uftc8inx 9441 13 ABO ABO NNP cord-010092-uftc8inx 9441 14 blood blood NN cord-010092-uftc8inx 9441 15 group group NN cord-010092-uftc8inx 9441 16 and and CC cord-010092-uftc8inx 9441 17 RhD rhd NN cord-010092-uftc8inx 9441 18 type type NN cord-010092-uftc8inx 9441 19 ( ( -LRB- cord-010092-uftc8inx 9441 20 I -PRON- PRP cord-010092-uftc8inx 9441 21 d d NN cord-010092-uftc8inx 9441 22 card card NN cord-010092-uftc8inx 9441 23 DiaClon DiaClon NNP cord-010092-uftc8inx 9441 24 ABO ABO NNP cord-010092-uftc8inx 9441 25 / / SYM cord-010092-uftc8inx 9441 26 D D NNP cord-010092-uftc8inx 9441 27 DV+ DV+ NNP cord-010092-uftc8inx 9441 28 , , , cord-010092-uftc8inx 9441 29 DV- DV- NNS cord-010092-uftc8inx 9441 30 , , , cord-010092-uftc8inx 9441 31 reverse reverse JJ cord-010092-uftc8inx 9441 32 grouping grouping NN cord-010092-uftc8inx 9441 33 , , , cord-010092-uftc8inx 9441 34 monoclonal monoclonal JJ cord-010092-uftc8inx 9441 35 antibodies antibody NNS cord-010092-uftc8inx 9441 36 , , , cord-010092-uftc8inx 9441 37 gel gel NN cord-010092-uftc8inx 9441 38 method method NN cord-010092-uftc8inx 9441 39 ) ) -RRB- cord-010092-uftc8inx 9441 40 , , , cord-010092-uftc8inx 9441 41 antiglobulin antiglobulin NNP cord-010092-uftc8inx 9441 42 crossmatch crossmatch NNP cord-010092-uftc8inx 9441 43 , , , cord-010092-uftc8inx 9441 44 additional additional JJ cord-010092-uftc8inx 9441 45 phenotyping phenotyping NN cord-010092-uftc8inx 9441 46 ( ( -LRB- cord-010092-uftc8inx 9441 47 gel gel NN cord-010092-uftc8inx 9441 48 and and CC cord-010092-uftc8inx 9441 49 tube tube NN cord-010092-uftc8inx 9441 50 methods method NNS cord-010092-uftc8inx 9441 51 ) ) -RRB- cord-010092-uftc8inx 9441 52 , , , cord-010092-uftc8inx 9441 53 antibody antibody NN cord-010092-uftc8inx 9441 54 screening screening NN cord-010092-uftc8inx 9441 55 , , , cord-010092-uftc8inx 9441 56 identification identification NN cord-010092-uftc8inx 9441 57 of of IN cord-010092-uftc8inx 9441 58 the the DT cord-010092-uftc8inx 9441 59 specificity specificity NN cord-010092-uftc8inx 9441 60 of of IN cord-010092-uftc8inx 9441 61 irregular irregular JJ cord-010092-uftc8inx 9441 62 anti anti JJ cord-010092-uftc8inx 9441 63 - - JJ cord-010092-uftc8inx 9441 64 erythrocyte erythrocyte JJ cord-010092-uftc8inx 9441 65 antibodies antibody NNS cord-010092-uftc8inx 9441 66 by by IN cord-010092-uftc8inx 9441 67 commercially commercially RB cord-010092-uftc8inx 9441 68 available available JJ cord-010092-uftc8inx 9441 69 red red JJ cord-010092-uftc8inx 9441 70 cell cell NN cord-010092-uftc8inx 9441 71 panels panel NNS cord-010092-uftc8inx 9441 72 ( ( -LRB- cord-010092-uftc8inx 9441 73 I -PRON- PRP cord-010092-uftc8inx 9441 74 d d NNP cord-010092-uftc8inx 9441 75 Dia Dia NNP cord-010092-uftc8inx 9441 76 - - HYPH cord-010092-uftc8inx 9441 77 Panel Panel NNP cord-010092-uftc8inx 9441 78 Bio Bio NNP cord-010092-uftc8inx 9441 79 Rad Rad NNP cord-010092-uftc8inx 9441 80 gel gel NN cord-010092-uftc8inx 9441 81 method method NN cord-010092-uftc8inx 9441 82 , , , cord-010092-uftc8inx 9441 83 Panocell Panocell NNP cord-010092-uftc8inx 9441 84 Immucor Immucor NNP cord-010092-uftc8inx 9441 85 , , , cord-010092-uftc8inx 9441 86 tube tube NN cord-010092-uftc8inx 9441 87 method method NN cord-010092-uftc8inx 9441 88 ) ) -RRB- cord-010092-uftc8inx 9441 89 through through IN cord-010092-uftc8inx 9441 90 an an DT cord-010092-uftc8inx 9441 91 indirect indirect JJ cord-010092-uftc8inx 9441 92 antiglobulin antiglobulin NN cord-010092-uftc8inx 9441 93 test test NN cord-010092-uftc8inx 9441 94 ( ( -LRB- cord-010092-uftc8inx 9441 95 IAT IAT NNP cord-010092-uftc8inx 9441 96 ) ) -RRB- cord-010092-uftc8inx 9441 97 and and CC cord-010092-uftc8inx 9441 98 enzymes enzyme NNS cord-010092-uftc8inx 9441 99 . . . cord-010092-uftc8inx 9442 1 After after IN cord-010092-uftc8inx 9442 2 routine routine JJ cord-010092-uftc8inx 9442 3 RhD rhd NN cord-010092-uftc8inx 9442 4 typing type VBG cord-010092-uftc8inx 9442 5 we -PRON- PRP cord-010092-uftc8inx 9442 6 continued continue VBD cord-010092-uftc8inx 9442 7 further further JJ cord-010092-uftc8inx 9442 8 characterisation characterisation NN cord-010092-uftc8inx 9442 9 of of IN cord-010092-uftc8inx 9442 10 the the DT cord-010092-uftc8inx 9442 11 RhD RhD NNP cord-010092-uftc8inx 9442 12 antigen antigen NN cord-010092-uftc8inx 9442 13 by by IN cord-010092-uftc8inx 9442 14 serologic serologic NNP cord-010092-uftc8inx 9442 15 assay assay NN cord-010092-uftc8inx 9443 1 ( ( -LRB- cord-010092-uftc8inx 9443 2 Bio Bio NNP cord-010092-uftc8inx 9443 3 - - HYPH cord-010092-uftc8inx 9443 4 Rad Rad NNP cord-010092-uftc8inx 9443 5 ID- id- NN cord-010092-uftc8inx 9444 1 Partial partial JJ cord-010092-uftc8inx 9444 2 RhD rhd NN cord-010092-uftc8inx 9445 1 typing),and typing),and NN cord-010092-uftc8inx 9445 2 finally finally RB cord-010092-uftc8inx 9445 3 by by IN cord-010092-uftc8inx 9445 4 RhD RhD NNP cord-010092-uftc8inx 9445 5 antigen antigen NNP cord-010092-uftc8inx 9445 6 molecular molecular JJ cord-010092-uftc8inx 9445 7 genotyping genotyping NN cord-010092-uftc8inx 9445 8 ( ( -LRB- cord-010092-uftc8inx 9445 9 FluoGene fluogene JJ cord-010092-uftc8inx 9445 10 method method NN cord-010092-uftc8inx 9445 11 on on IN cord-010092-uftc8inx 9445 12 Fluo Fluo NNP cord-010092-uftc8inx 9445 13 Vista Vista NNP cord-010092-uftc8inx 9445 14 machine machine NN cord-010092-uftc8inx 9445 15 ) ) -RRB- cord-010092-uftc8inx 9445 16 . . . cord-010092-uftc8inx 9446 1 Results result NNS cord-010092-uftc8inx 9446 2 : : : cord-010092-uftc8inx 9447 1 Our -PRON- PRP$ cord-010092-uftc8inx 9447 2 patient patient NN cord-010092-uftc8inx 9447 3 is be VBZ cord-010092-uftc8inx 9447 4 a a DT cord-010092-uftc8inx 9447 5 75 75 CD cord-010092-uftc8inx 9447 6 year year NN cord-010092-uftc8inx 9447 7 old old JJ cord-010092-uftc8inx 9447 8 woman woman NN cord-010092-uftc8inx 9447 9 with with IN cord-010092-uftc8inx 9447 10 a a DT cord-010092-uftc8inx 9447 11 diagnosis diagnosis NN cord-010092-uftc8inx 9447 12 of of IN cord-010092-uftc8inx 9447 13 Tu Tu NNP cord-010092-uftc8inx 9447 14 mammae mammae NNP cord-010092-uftc8inx 9447 15 who who WP cord-010092-uftc8inx 9447 16 was be VBD cord-010092-uftc8inx 9447 17 preparing prepare VBG cord-010092-uftc8inx 9447 18 for for IN cord-010092-uftc8inx 9447 19 total total JJ cord-010092-uftc8inx 9447 20 mastectomy mastectomy NN cord-010092-uftc8inx 9447 21 surgery surgery NN cord-010092-uftc8inx 9447 22 . . . cord-010092-uftc8inx 9448 1 She -PRON- PRP cord-010092-uftc8inx 9448 2 had have VBD cord-010092-uftc8inx 9448 3 a a DT cord-010092-uftc8inx 9448 4 history history NN cord-010092-uftc8inx 9448 5 of of IN cord-010092-uftc8inx 9448 6 blood blood NN cord-010092-uftc8inx 9448 7 transfusions transfusion NNS cord-010092-uftc8inx 9448 8 twenty twenty CD cord-010092-uftc8inx 9448 9 years year NNS cord-010092-uftc8inx 9448 10 ago ago RB cord-010092-uftc8inx 9448 11 , , , cord-010092-uftc8inx 9448 12 and and CC cord-010092-uftc8inx 9448 13 she -PRON- PRP cord-010092-uftc8inx 9448 14 also also RB cord-010092-uftc8inx 9448 15 had have VBD cord-010092-uftc8inx 9448 16 two two CD cord-010092-uftc8inx 9448 17 births birth NNS cord-010092-uftc8inx 9448 18 . . . cord-010092-uftc8inx 9449 1 The the DT cord-010092-uftc8inx 9449 2 blood blood NN cord-010092-uftc8inx 9449 3 group group NN cord-010092-uftc8inx 9449 4 typing typing NN cord-010092-uftc8inx 9449 5 was be VBD cord-010092-uftc8inx 9449 6 : : : cord-010092-uftc8inx 9449 7 O o UH cord-010092-uftc8inx 9449 8 , , , cord-010092-uftc8inx 9449 9 CcDee CcDee NNP cord-010092-uftc8inx 9449 10 , , , cord-010092-uftc8inx 9449 11 K- K- NNP cord-010092-uftc8inx 9449 12 , , , cord-010092-uftc8inx 9449 13 Fy Fy NNP cord-010092-uftc8inx 9449 14 ( ( -LRB- cord-010092-uftc8inx 9449 15 a a NN cord-010092-uftc8inx 9449 16 - - HYPH cord-010092-uftc8inx 9449 17 b b NN cord-010092-uftc8inx 9449 18 + + CC cord-010092-uftc8inx 9449 19 ) ) -RRB- cord-010092-uftc8inx 9449 20 , , . cord-010092-uftc8inx 9450 1 Jk Jk NNP cord-010092-uftc8inx 9451 1 ( ( -LRB- cord-010092-uftc8inx 9451 2 a+b a+b CD cord-010092-uftc8inx 9451 3 + + SYM cord-010092-uftc8inx 9451 4 ) ) -RRB- cord-010092-uftc8inx 9451 5 , , , cord-010092-uftc8inx 9451 6 Ss Ss NNP cord-010092-uftc8inx 9451 7 , , , cord-010092-uftc8inx 9451 8 MN MN NNP cord-010092-uftc8inx 9451 9 , , , cord-010092-uftc8inx 9451 10 Le Le NNP cord-010092-uftc8inx 9451 11 ( ( -LRB- cord-010092-uftc8inx 9451 12 a+b a+b NNP cord-010092-uftc8inx 9451 13 - - -RRB- cord-010092-uftc8inx 9451 14 ) ) -RRB- cord-010092-uftc8inx 9451 15 . . . cord-010092-uftc8inx 9452 1 The the DT cord-010092-uftc8inx 9452 2 agglutination agglutination NN cord-010092-uftc8inx 9452 3 reactions reaction NNS cord-010092-uftc8inx 9452 4 that that WDT cord-010092-uftc8inx 9452 5 we -PRON- PRP cord-010092-uftc8inx 9452 6 tested test VBD cord-010092-uftc8inx 9452 7 with with IN cord-010092-uftc8inx 9452 8 anti anti NNP cord-010092-uftc8inx 9452 9 D D NNP cord-010092-uftc8inx 9452 10 serums serum NNS cord-010092-uftc8inx 9452 11 were be VBD cord-010092-uftc8inx 9452 12 strong strong JJ cord-010092-uftc8inx 9452 13 ( ( -LRB- cord-010092-uftc8inx 9452 14 4 4 CD cord-010092-uftc8inx 9452 15 + + CD cord-010092-uftc8inx 9452 16 ) ) -RRB- cord-010092-uftc8inx 9452 17 . . . cord-010092-uftc8inx 9453 1 The the DT cord-010092-uftc8inx 9453 2 compatibility compatibility NN cord-010092-uftc8inx 9453 3 test test NN cord-010092-uftc8inx 9453 4 with with IN cord-010092-uftc8inx 9453 5 RhD RhD NNP cord-010092-uftc8inx 9453 6 positive positive JJ cord-010092-uftc8inx 9453 7 donated donate VBN cord-010092-uftc8inx 9453 8 blood blood NN cord-010092-uftc8inx 9453 9 units unit NNS cord-010092-uftc8inx 9453 10 was be VBD cord-010092-uftc8inx 9453 11 positive positive JJ cord-010092-uftc8inx 9453 12 . . . cord-010092-uftc8inx 9454 1 The the DT cord-010092-uftc8inx 9454 2 presence presence NN cord-010092-uftc8inx 9454 3 of of IN cord-010092-uftc8inx 9454 4 anti anti JJ cord-010092-uftc8inx 9454 5 - - JJ cord-010092-uftc8inx 9454 6 D d JJ cord-010092-uftc8inx 9454 7 and and CC cord-010092-uftc8inx 9454 8 anti anti JJ cord-010092-uftc8inx 9454 9 - - JJ cord-010092-uftc8inx 9454 10 Fya fya JJ cord-010092-uftc8inx 9454 11 antibodies antibody NNS cord-010092-uftc8inx 9454 12 in in IN cord-010092-uftc8inx 9454 13 the the DT cord-010092-uftc8inx 9454 14 serum serum NN cord-010092-uftc8inx 9454 15 of of IN cord-010092-uftc8inx 9454 16 the the DT cord-010092-uftc8inx 9454 17 patient patient NN cord-010092-uftc8inx 9454 18 was be VBD cord-010092-uftc8inx 9454 19 determined determine VBN cord-010092-uftc8inx 9454 20 . . . cord-010092-uftc8inx 9455 1 We -PRON- PRP cord-010092-uftc8inx 9455 2 prepared prepare VBD cord-010092-uftc8inx 9455 3 one one CD cord-010092-uftc8inx 9455 4 compatible compatible JJ cord-010092-uftc8inx 9455 5 blood blood NN cord-010092-uftc8inx 9455 6 unit unit NN cord-010092-uftc8inx 9455 7 , , , cord-010092-uftc8inx 9455 8 RhD RhD NNP cord-010092-uftc8inx 9455 9 negative negative JJ cord-010092-uftc8inx 9455 10 and and CC cord-010092-uftc8inx 9455 11 Fya Fya NNP cord-010092-uftc8inx 9455 12 negative negative NN cord-010092-uftc8inx 9455 13 , , , cord-010092-uftc8inx 9455 14 for for IN cord-010092-uftc8inx 9455 15 a a DT cord-010092-uftc8inx 9455 16 surgery surgery NN cord-010092-uftc8inx 9455 17 . . . cord-010092-uftc8inx 9456 1 Interpretation interpretation NN cord-010092-uftc8inx 9456 2 of of IN cord-010092-uftc8inx 9456 3 the the DT cord-010092-uftc8inx 9456 4 ID ID NNP cord-010092-uftc8inx 9456 5 - - HYPH cord-010092-uftc8inx 9456 6 Partial Partial NNP cord-010092-uftc8inx 9456 7 Rh Rh NNP cord-010092-uftc8inx 9456 8 D D NNP cord-010092-uftc8inx 9456 9 typing typing NN cord-010092-uftc8inx 9456 10 set set NN cord-010092-uftc8inx 9456 11 indicated indicate VBD cord-010092-uftc8inx 9456 12 that that IN cord-010092-uftc8inx 9456 13 this this DT cord-010092-uftc8inx 9456 14 is be VBZ cord-010092-uftc8inx 9456 15 a a DT cord-010092-uftc8inx 9456 16 DIII DIII NNP cord-010092-uftc8inx 9456 17 category category NN cord-010092-uftc8inx 9456 18 of of IN cord-010092-uftc8inx 9456 19 D d JJ cord-010092-uftc8inx 9456 20 partial partial JJ cord-010092-uftc8inx 9456 21 antigen antigen NN cord-010092-uftc8inx 9456 22 . . . cord-010092-uftc8inx 9457 1 A a DT cord-010092-uftc8inx 9457 2 sample sample NN cord-010092-uftc8inx 9457 3 of of IN cord-010092-uftc8inx 9457 4 blood blood NN cord-010092-uftc8inx 9457 5 of of IN cord-010092-uftc8inx 9457 6 our -PRON- PRP$ cord-010092-uftc8inx 9457 7 patient patient NN cord-010092-uftc8inx 9457 8 was be VBD cord-010092-uftc8inx 9457 9 sent send VBN cord-010092-uftc8inx 9457 10 to to IN cord-010092-uftc8inx 9457 11 the the DT cord-010092-uftc8inx 9457 12 Blood Blood NNP cord-010092-uftc8inx 9457 13 Transfusion Transfusion NNP cord-010092-uftc8inx 9457 14 Institute Institute NNP cord-010092-uftc8inx 9457 15 of of IN cord-010092-uftc8inx 9457 16 Serbia Serbia NNP cord-010092-uftc8inx 9457 17 , , , cord-010092-uftc8inx 9457 18 where where WRB cord-010092-uftc8inx 9457 19 molecular molecular JJ cord-010092-uftc8inx 9457 20 typing typing NN cord-010092-uftc8inx 9457 21 of of IN cord-010092-uftc8inx 9457 22 D D NNP cord-010092-uftc8inx 9457 23 antigen antigen NN cord-010092-uftc8inx 9457 24 was be VBD cord-010092-uftc8inx 9457 25 performed perform VBN cord-010092-uftc8inx 9457 26 and and CC cord-010092-uftc8inx 9457 27 the the DT cord-010092-uftc8inx 9457 28 presence presence NN cord-010092-uftc8inx 9457 29 of of IN cord-010092-uftc8inx 9457 30 partial partial JJ cord-010092-uftc8inx 9457 31 form form NN cord-010092-uftc8inx 9457 32 of of IN cord-010092-uftc8inx 9457 33 antigen antigen NN cord-010092-uftc8inx 9457 34 D D NNP cord-010092-uftc8inx 9457 35 , , , cord-010092-uftc8inx 9457 36 DNB dnb NN cord-010092-uftc8inx 9457 37 type type NN cord-010092-uftc8inx 9457 38 , , , cord-010092-uftc8inx 9457 39 was be VBD cord-010092-uftc8inx 9457 40 found find VBN cord-010092-uftc8inx 9457 41 . . . cord-010092-uftc8inx 9458 1 Summary Summary NNP cord-010092-uftc8inx 9458 2 / / SYM cord-010092-uftc8inx 9458 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 9458 4 : : : cord-010092-uftc8inx 9459 1 RhD RhD NNP cord-010092-uftc8inx 9459 2 positive positive JJ cord-010092-uftc8inx 9459 3 patients patient NNS cord-010092-uftc8inx 9459 4 or or CC cord-010092-uftc8inx 9459 5 donors donor NNS cord-010092-uftc8inx 9459 6 with with IN cord-010092-uftc8inx 9459 7 anti anti JJ cord-010092-uftc8inx 9459 8 - - JJ cord-010092-uftc8inx 9459 9 D d JJ cord-010092-uftc8inx 9459 10 antibody antibody NN cord-010092-uftc8inx 9459 11 presents present VBZ cord-010092-uftc8inx 9459 12 in in IN cord-010092-uftc8inx 9459 13 their -PRON- PRP$ cord-010092-uftc8inx 9459 14 serum serum NN cord-010092-uftc8inx 9459 15 should should MD cord-010092-uftc8inx 9459 16 be be VB cord-010092-uftc8inx 9459 17 tested test VBN cord-010092-uftc8inx 9459 18 for for IN cord-010092-uftc8inx 9459 19 D d NN cord-010092-uftc8inx 9459 20 genotyping genotyping NN cord-010092-uftc8inx 9459 21 . . . cord-010092-uftc8inx 9460 1 The the DT cord-010092-uftc8inx 9460 2 recommendation recommendation NN cord-010092-uftc8inx 9460 3 for for IN cord-010092-uftc8inx 9460 4 further further JJ cord-010092-uftc8inx 9460 5 transfusions transfusion NNS cord-010092-uftc8inx 9460 6 of of IN cord-010092-uftc8inx 9460 7 our -PRON- PRP$ cord-010092-uftc8inx 9460 8 patient patient NN cord-010092-uftc8inx 9460 9 with with IN cord-010092-uftc8inx 9460 10 DNB DNB NNP cord-010092-uftc8inx 9460 11 D D NNP cord-010092-uftc8inx 9460 12 partial partial NN cord-010092-uftc8inx 9460 13 and and CC cord-010092-uftc8inx 9460 14 her -PRON- PRP$ cord-010092-uftc8inx 9460 15 alloimmunisation alloimmunisation NN cord-010092-uftc8inx 9460 16 is be VBZ cord-010092-uftc8inx 9460 17 to to TO cord-010092-uftc8inx 9460 18 prepare prepare VB cord-010092-uftc8inx 9460 19 D D NNP cord-010092-uftc8inx 9460 20 negative negative JJ cord-010092-uftc8inx 9460 21 , , , cord-010092-uftc8inx 9460 22 Fya Fya NNP cord-010092-uftc8inx 9460 23 negative negative JJ cord-010092-uftc8inx 9460 24 erythrocytic erythrocytic JJ cord-010092-uftc8inx 9460 25 blood blood NN cord-010092-uftc8inx 9460 26 components component NNS cord-010092-uftc8inx 9460 27 , , , cord-010092-uftc8inx 9460 28 and and CC cord-010092-uftc8inx 9460 29 as as IN cord-010092-uftc8inx 9460 30 a a DT cord-010092-uftc8inx 9460 31 possible possible JJ cord-010092-uftc8inx 9460 32 blood blood NN cord-010092-uftc8inx 9460 33 donor donor NN cord-010092-uftc8inx 9460 34 it -PRON- PRP cord-010092-uftc8inx 9460 35 would would MD cord-010092-uftc8inx 9460 36 be be VB cord-010092-uftc8inx 9460 37 labeled label VBN cord-010092-uftc8inx 9460 38 as as IN cord-010092-uftc8inx 9460 39 Rh Rh NNP cord-010092-uftc8inx 9460 40 D D NNP cord-010092-uftc8inx 9460 41 positive positive JJ cord-010092-uftc8inx 9460 42 . . . cord-010092-uftc8inx 9461 1 Background background NN cord-010092-uftc8inx 9461 2 : : : cord-010092-uftc8inx 9462 1 The the DT cord-010092-uftc8inx 9462 2 JR JR NNP cord-010092-uftc8inx 9462 3 blood blood NN cord-010092-uftc8inx 9462 4 group group NN cord-010092-uftc8inx 9462 5 system system NN cord-010092-uftc8inx 9462 6 consists consist VBZ cord-010092-uftc8inx 9462 7 of of IN cord-010092-uftc8inx 9462 8 Jr Jr NNP cord-010092-uftc8inx 9462 9 a a DT cord-010092-uftc8inx 9462 10 ( ( -LRB- cord-010092-uftc8inx 9462 11 JR1 JR1 NNP cord-010092-uftc8inx 9462 12 ) ) -RRB- cord-010092-uftc8inx 9462 13 , , , cord-010092-uftc8inx 9462 14 a a DT cord-010092-uftc8inx 9462 15 high high JJ cord-010092-uftc8inx 9462 16 frequency frequency NN cord-010092-uftc8inx 9462 17 antigen antigen NN cord-010092-uftc8inx 9462 18 expressed express VBN cord-010092-uftc8inx 9462 19 by by IN cord-010092-uftc8inx 9462 20 the the DT cord-010092-uftc8inx 9462 21 ABCG2 abcg2 NN cord-010092-uftc8inx 9462 22 gene gene NN cord-010092-uftc8inx 9462 23 . . . cord-010092-uftc8inx 9463 1 The the DT cord-010092-uftc8inx 9463 2 individuals individual NNS cord-010092-uftc8inx 9463 3 with with IN cord-010092-uftc8inx 9463 4 Jr(a- jr(a- CD cord-010092-uftc8inx 9463 5 ) ) -RRB- cord-010092-uftc8inx 9463 6 phenotype phenotype NN cord-010092-uftc8inx 9463 7 are be VBP cord-010092-uftc8inx 9463 8 mainly mainly RB cord-010092-uftc8inx 9463 9 found find VBN cord-010092-uftc8inx 9463 10 in in IN cord-010092-uftc8inx 9463 11 the the DT cord-010092-uftc8inx 9463 12 Japanese japanese JJ cord-010092-uftc8inx 9463 13 population population NN cord-010092-uftc8inx 9463 14 and and CC cord-010092-uftc8inx 9463 15 may may MD cord-010092-uftc8inx 9463 16 develop develop VB cord-010092-uftc8inx 9463 17 anti anti JJ cord-010092-uftc8inx 9463 18 - - NNP cord-010092-uftc8inx 9463 19 Jr Jr NNP cord-010092-uftc8inx 9463 20 a a NNP cord-010092-uftc8inx 9463 21 when when WRB cord-010092-uftc8inx 9463 22 stimulated stimulate VBN cord-010092-uftc8inx 9463 23 by by IN cord-010092-uftc8inx 9463 24 blood blood NN cord-010092-uftc8inx 9463 25 transfusion transfusion NN cord-010092-uftc8inx 9463 26 or or CC cord-010092-uftc8inx 9463 27 pregnancy pregnancy NN cord-010092-uftc8inx 9463 28 . . . cord-010092-uftc8inx 9464 1 Anti Anti NNP cord-010092-uftc8inx 9464 2 - - NNP cord-010092-uftc8inx 9464 3 Jr Jr NNP cord-010092-uftc8inx 9464 4 a a NNP cord-010092-uftc8inx 9464 5 is be VBZ cord-010092-uftc8inx 9464 6 a a DT cord-010092-uftc8inx 9464 7 dangerous dangerous JJ cord-010092-uftc8inx 9464 8 antibody antibody NN cord-010092-uftc8inx 9464 9 for for IN cord-010092-uftc8inx 9464 10 pregnancy pregnancy NN cord-010092-uftc8inx 9464 11 , , , cord-010092-uftc8inx 9464 12 but but CC cord-010092-uftc8inx 9464 13 also also RB cord-010092-uftc8inx 9464 14 could could MD cord-010092-uftc8inx 9464 15 cause cause VB cord-010092-uftc8inx 9464 16 mild mild JJ cord-010092-uftc8inx 9464 17 or or CC cord-010092-uftc8inx 9464 18 moderate moderate JJ cord-010092-uftc8inx 9464 19 neonatal neonatal JJ cord-010092-uftc8inx 9464 20 jaundice jaundice NN cord-010092-uftc8inx 9464 21 . . . cord-010092-uftc8inx 9465 1 Aims aim VBZ cord-010092-uftc8inx 9465 2 : : : cord-010092-uftc8inx 9466 1 To to TO cord-010092-uftc8inx 9466 2 conduct conduct VB cord-010092-uftc8inx 9466 3 the the DT cord-010092-uftc8inx 9466 4 antibody antibody NN cord-010092-uftc8inx 9466 5 specificity specificity NN cord-010092-uftc8inx 9466 6 identification identification NN cord-010092-uftc8inx 9466 7 of of IN cord-010092-uftc8inx 9466 8 the the DT cord-010092-uftc8inx 9466 9 high high JJ cord-010092-uftc8inx 9466 10 frequency frequency NN cord-010092-uftc8inx 9466 11 antibody antibody NN cord-010092-uftc8inx 9466 12 in in IN cord-010092-uftc8inx 9466 13 a a DT cord-010092-uftc8inx 9466 14 pregnant pregnant JJ cord-010092-uftc8inx 9466 15 woman woman NN cord-010092-uftc8inx 9466 16 with with IN cord-010092-uftc8inx 9466 17 history history NN cord-010092-uftc8inx 9466 18 of of IN cord-010092-uftc8inx 9466 19 pregnancy pregnancy NN cord-010092-uftc8inx 9466 20 but but CC cord-010092-uftc8inx 9466 21 no no DT cord-010092-uftc8inx 9466 22 transfusion transfusion NN cord-010092-uftc8inx 9466 23 . . . cord-010092-uftc8inx 9467 1 Methods method NNS cord-010092-uftc8inx 9467 2 : : : cord-010092-uftc8inx 9467 3 ABO ABO NNP cord-010092-uftc8inx 9467 4 , , , cord-010092-uftc8inx 9467 5 RhD rhd NN cord-010092-uftc8inx 9467 6 and and CC cord-010092-uftc8inx 9467 7 some some DT cord-010092-uftc8inx 9467 8 special special JJ cord-010092-uftc8inx 9467 9 blood blood NN cord-010092-uftc8inx 9467 10 group group NN cord-010092-uftc8inx 9467 11 antigens antigen NNS cord-010092-uftc8inx 9467 12 were be VBD cord-010092-uftc8inx 9467 13 identified identify VBN cord-010092-uftc8inx 9467 14 by by IN cord-010092-uftc8inx 9467 15 tube tube NN cord-010092-uftc8inx 9467 16 method method NN cord-010092-uftc8inx 9467 17 in in IN cord-010092-uftc8inx 9467 18 saline saline NN cord-010092-uftc8inx 9467 19 . . . cord-010092-uftc8inx 9468 1 Antibody antibody NN cord-010092-uftc8inx 9468 2 screening screening NN cord-010092-uftc8inx 9468 3 and and CC cord-010092-uftc8inx 9468 4 blood blood NN cord-010092-uftc8inx 9468 5 group group NN cord-010092-uftc8inx 9468 6 specific specific JJ cord-010092-uftc8inx 9468 7 antibody antibody NN cord-010092-uftc8inx 9468 8 identification identification NN cord-010092-uftc8inx 9468 9 were be VBD cord-010092-uftc8inx 9468 10 performed perform VBN cord-010092-uftc8inx 9468 11 by by IN cord-010092-uftc8inx 9468 12 indirect indirect JJ cord-010092-uftc8inx 9468 13 antiglobulin antiglobulin NN cord-010092-uftc8inx 9468 14 test test NN cord-010092-uftc8inx 9468 15 ( ( -LRB- cord-010092-uftc8inx 9468 16 IAT IAT NNP cord-010092-uftc8inx 9468 17 ) ) -RRB- cord-010092-uftc8inx 9468 18 in in IN cord-010092-uftc8inx 9468 19 gel gel NN cord-010092-uftc8inx 9468 20 column column NN cord-010092-uftc8inx 9468 21 . . . cord-010092-uftc8inx 9469 1 The the DT cord-010092-uftc8inx 9469 2 reagent reagent NN cord-010092-uftc8inx 9469 3 cells cell NNS cord-010092-uftc8inx 9469 4 treated treat VBN cord-010092-uftc8inx 9469 5 with with IN cord-010092-uftc8inx 9469 6 trypsin trypsin NN cord-010092-uftc8inx 9469 7 , , , cord-010092-uftc8inx 9469 8 chymotrypsin chymotrypsin NNP cord-010092-uftc8inx 9469 9 and and CC cord-010092-uftc8inx 9469 10 papain papain NN cord-010092-uftc8inx 9469 11 , , , cord-010092-uftc8inx 9469 12 were be VBD cord-010092-uftc8inx 9469 13 used use VBN cord-010092-uftc8inx 9469 14 to to TO cord-010092-uftc8inx 9469 15 test test VB cord-010092-uftc8inx 9469 16 the the DT cord-010092-uftc8inx 9469 17 antiserum antiserum NN cord-010092-uftc8inx 9469 18 to to TO cord-010092-uftc8inx 9469 19 obtain obtain VB cord-010092-uftc8inx 9469 20 the the DT cord-010092-uftc8inx 9469 21 characteristic characteristic NN cord-010092-uftc8inx 9469 22 of of IN cord-010092-uftc8inx 9469 23 antibody antibody NN cord-010092-uftc8inx 9469 24 reaction reaction NN cord-010092-uftc8inx 9469 25 . . . cord-010092-uftc8inx 9470 1 The the DT cord-010092-uftc8inx 9470 2 antibody antibody NN cord-010092-uftc8inx 9470 3 titer titer NN cord-010092-uftc8inx 9470 4 in in IN cord-010092-uftc8inx 9470 5 the the DT cord-010092-uftc8inx 9470 6 patient patient NN cord-010092-uftc8inx 9470 7 's 's POS cord-010092-uftc8inx 9470 8 serum serum NN cord-010092-uftc8inx 9470 9 was be VBD cord-010092-uftc8inx 9470 10 detected detect VBN cord-010092-uftc8inx 9470 11 . . . cord-010092-uftc8inx 9471 1 DNA dna NN cord-010092-uftc8inx 9471 2 sample sample NN cord-010092-uftc8inx 9471 3 was be VBD cord-010092-uftc8inx 9471 4 extracted extract VBN cord-010092-uftc8inx 9471 5 and and CC cord-010092-uftc8inx 9471 6 16 16 CD cord-010092-uftc8inx 9471 7 exons exon NNS cord-010092-uftc8inx 9471 8 and and CC cord-010092-uftc8inx 9471 9 adjacent adjacent JJ cord-010092-uftc8inx 9471 10 intronic intronic JJ cord-010092-uftc8inx 9471 11 sequence sequence NN cord-010092-uftc8inx 9471 12 of of IN cord-010092-uftc8inx 9471 13 the the DT cord-010092-uftc8inx 9471 14 ABCG2 abcg2 NN cord-010092-uftc8inx 9471 15 gene gene NN cord-010092-uftc8inx 9471 16 were be VBD cord-010092-uftc8inx 9471 17 sequenced sequence VBN cord-010092-uftc8inx 9471 18 . . . cord-010092-uftc8inx 9472 1 The the DT cord-010092-uftc8inx 9472 2 sample sample NN cord-010092-uftc8inx 9472 3 of of IN cord-010092-uftc8inx 9472 4 one one CD cord-010092-uftc8inx 9472 5 family family NN cord-010092-uftc8inx 9472 6 member member NN cord-010092-uftc8inx 9472 7 was be VBD cord-010092-uftc8inx 9472 8 collected collect VBN cord-010092-uftc8inx 9472 9 for for IN cord-010092-uftc8inx 9472 10 testing testing NN cord-010092-uftc8inx 9472 11 . . . cord-010092-uftc8inx 9473 1 Results result NNS cord-010092-uftc8inx 9473 2 : : : cord-010092-uftc8inx 9474 1 The the DT cord-010092-uftc8inx 9474 2 blood blood NN cord-010092-uftc8inx 9474 3 groups group NNS cord-010092-uftc8inx 9474 4 of of IN cord-010092-uftc8inx 9474 5 the the DT cord-010092-uftc8inx 9474 6 patient patient NN cord-010092-uftc8inx 9474 7 were be VBD cord-010092-uftc8inx 9474 8 B b NN cord-010092-uftc8inx 9474 9 , , , cord-010092-uftc8inx 9474 10 RhD(+ RhD(+ NNS cord-010092-uftc8inx 9474 11 ) ) -RRB- cord-010092-uftc8inx 9474 12 , , , cord-010092-uftc8inx 9474 13 LU LU NNP cord-010092-uftc8inx 9474 14 b b NNP cord-010092-uftc8inx 9474 15 ( ( -LRB- cord-010092-uftc8inx 9474 16 + + NN cord-010092-uftc8inx 9474 17 ) ) -RRB- cord-010092-uftc8inx 9474 18 and and CC cord-010092-uftc8inx 9474 19 Kp Kp NNP cord-010092-uftc8inx 9474 20 b b NNP cord-010092-uftc8inx 9474 21 ( ( -LRB- cord-010092-uftc8inx 9474 22 + + NN cord-010092-uftc8inx 9474 23 ) ) -RRB- cord-010092-uftc8inx 9474 24 . . . cord-010092-uftc8inx 9475 1 The the DT cord-010092-uftc8inx 9475 2 negative negative JJ cord-010092-uftc8inx 9475 3 reaction reaction NN cord-010092-uftc8inx 9475 4 of of IN cord-010092-uftc8inx 9475 5 the the DT cord-010092-uftc8inx 9475 6 serum serum NN cord-010092-uftc8inx 9475 7 reacted react VBD cord-010092-uftc8inx 9475 8 with with IN cord-010092-uftc8inx 9475 9 all all DT cord-010092-uftc8inx 9475 10 reagent reagent NN cord-010092-uftc8inx 9475 11 cells cell NNS cord-010092-uftc8inx 9475 12 were be VBD cord-010092-uftc8inx 9475 13 tested test VBN cord-010092-uftc8inx 9475 14 in in IN cord-010092-uftc8inx 9475 15 saline saline NN cord-010092-uftc8inx 9475 16 , , , cord-010092-uftc8inx 9475 17 but but CC cord-010092-uftc8inx 9475 18 positive positive JJ cord-010092-uftc8inx 9475 19 ( ( -LRB- cord-010092-uftc8inx 9475 20 2 2 CD cord-010092-uftc8inx 9475 21 + + CD cord-010092-uftc8inx 9475 22 ) ) -RRB- cord-010092-uftc8inx 9476 1 in in IN cord-010092-uftc8inx 9476 2 IAT IAT NNP cord-010092-uftc8inx 9476 3 test test NN cord-010092-uftc8inx 9476 4 , , , cord-010092-uftc8inx 9476 5 while while IN cord-010092-uftc8inx 9476 6 the the DT cord-010092-uftc8inx 9476 7 self self NN cord-010092-uftc8inx 9476 8 - - HYPH cord-010092-uftc8inx 9476 9 control control NN cord-010092-uftc8inx 9476 10 was be VBD cord-010092-uftc8inx 9476 11 negative negative JJ cord-010092-uftc8inx 9476 12 . . . cord-010092-uftc8inx 9477 1 The the DT cord-010092-uftc8inx 9477 2 antiserums antiserum NNS cord-010092-uftc8inx 9477 3 reacted react VBD cord-010092-uftc8inx 9477 4 strongly strongly RB cord-010092-uftc8inx 9477 5 ( ( -LRB- cord-010092-uftc8inx 9477 6 4 4 CD cord-010092-uftc8inx 9477 7 + + SYM cord-010092-uftc8inx 9477 8 in in IN cord-010092-uftc8inx 9477 9 IAT IAT NNP cord-010092-uftc8inx 9477 10 test test NN cord-010092-uftc8inx 9477 11 in in IN cord-010092-uftc8inx 9477 12 Gel gel NN cord-010092-uftc8inx 9477 13 card card NN cord-010092-uftc8inx 9477 14 ) ) -RRB- cord-010092-uftc8inx 9477 15 with with IN cord-010092-uftc8inx 9477 16 the the DT cord-010092-uftc8inx 9477 17 papain papain NN cord-010092-uftc8inx 9477 18 - - HYPH cord-010092-uftc8inx 9477 19 treated treat VBN cord-010092-uftc8inx 9477 20 cells cell NNS cord-010092-uftc8inx 9477 21 , , , cord-010092-uftc8inx 9477 22 but but CC cord-010092-uftc8inx 9477 23 kept keep VBD cord-010092-uftc8inx 9477 24 the the DT cord-010092-uftc8inx 9477 25 same same JJ cord-010092-uftc8inx 9477 26 reaction reaction NN cord-010092-uftc8inx 9477 27 strength strength NN cord-010092-uftc8inx 9477 28 ( ( -LRB- cord-010092-uftc8inx 9477 29 2 2 CD cord-010092-uftc8inx 9477 30 + + SYM cord-010092-uftc8inx 9477 31 ) ) -RRB- cord-010092-uftc8inx 9477 32 with with IN cord-010092-uftc8inx 9477 33 trypsin trypsin NN cord-010092-uftc8inx 9477 34 - - HYPH cord-010092-uftc8inx 9477 35 and and CC cord-010092-uftc8inx 9477 36 chymotrypsin chymotrypsin NN cord-010092-uftc8inx 9477 37 - - HYPH cord-010092-uftc8inx 9477 38 treated treat VBN cord-010092-uftc8inx 9477 39 cells cell NNS cord-010092-uftc8inx 9477 40 , , , cord-010092-uftc8inx 9477 41 which which WDT cord-010092-uftc8inx 9477 42 indicated indicate VBD cord-010092-uftc8inx 9477 43 the the DT cord-010092-uftc8inx 9477 44 possible possible JJ cord-010092-uftc8inx 9477 45 existence existence NN cord-010092-uftc8inx 9477 46 of of IN cord-010092-uftc8inx 9477 47 anti anti JJ cord-010092-uftc8inx 9477 48 - - NNP cord-010092-uftc8inx 9477 49 Jr Jr NNP cord-010092-uftc8inx 9477 50 a a NNP cord-010092-uftc8inx 9477 51 . . . cord-010092-uftc8inx 9478 1 The the DT cord-010092-uftc8inx 9478 2 titer titer NN cord-010092-uftc8inx 9478 3 of of IN cord-010092-uftc8inx 9478 4 IgG IgG NNP cord-010092-uftc8inx 9478 5 antibody antibody NN cord-010092-uftc8inx 9478 6 in in IN cord-010092-uftc8inx 9478 7 serum serum NN cord-010092-uftc8inx 9478 8 was be VBD cord-010092-uftc8inx 9478 9 2 2 CD cord-010092-uftc8inx 9478 10 . . . cord-010092-uftc8inx 9479 1 In in IN cord-010092-uftc8inx 9479 2 Cross Cross NNP cord-010092-uftc8inx 9479 3 matching matching NN cord-010092-uftc8inx 9479 4 test test NN cord-010092-uftc8inx 9479 5 , , , cord-010092-uftc8inx 9479 6 the the DT cord-010092-uftc8inx 9479 7 red red JJ cord-010092-uftc8inx 9479 8 blood blood NN cord-010092-uftc8inx 9479 9 cell cell NN cord-010092-uftc8inx 9479 10 of of IN cord-010092-uftc8inx 9479 11 the the DT cord-010092-uftc8inx 9479 12 patient patient NN cord-010092-uftc8inx 9479 13 's 's POS cord-010092-uftc8inx 9479 14 brother brother NN cord-010092-uftc8inx 9479 15 with with IN cord-010092-uftc8inx 9479 16 the the DT cord-010092-uftc8inx 9479 17 same same JJ cord-010092-uftc8inx 9479 18 ABO ABO NNP cord-010092-uftc8inx 9479 19 and and CC cord-010092-uftc8inx 9479 20 RhD RhD NNP cord-010092-uftc8inx 9479 21 blood blood NNP cord-010092-uftc8inx 9479 22 group group NN cord-010092-uftc8inx 9479 23 with with IN cord-010092-uftc8inx 9479 24 the the DT cord-010092-uftc8inx 9479 25 patient patient NN cord-010092-uftc8inx 9479 26 was be VBD cord-010092-uftc8inx 9479 27 successfully successfully RB cord-010092-uftc8inx 9479 28 matched match VBN cord-010092-uftc8inx 9479 29 with with IN cord-010092-uftc8inx 9479 30 the the DT cord-010092-uftc8inx 9479 31 serum serum NN cord-010092-uftc8inx 9479 32 of of IN cord-010092-uftc8inx 9479 33 the the DT cord-010092-uftc8inx 9479 34 patient patient NN cord-010092-uftc8inx 9479 35 . . . cord-010092-uftc8inx 9480 1 The the DT cord-010092-uftc8inx 9480 2 sequencing sequencing NN cord-010092-uftc8inx 9480 3 analysis analysis NN cord-010092-uftc8inx 9480 4 of of IN cord-010092-uftc8inx 9480 5 the the DT cord-010092-uftc8inx 9480 6 ABCG2 abcg2 NN cord-010092-uftc8inx 9480 7 gene gene NN cord-010092-uftc8inx 9480 8 in in IN cord-010092-uftc8inx 9480 9 the the DT cord-010092-uftc8inx 9480 10 patient patient NN cord-010092-uftc8inx 9480 11 and and CC cord-010092-uftc8inx 9480 12 her -PRON- PRP$ cord-010092-uftc8inx 9480 13 brother brother NN cord-010092-uftc8inx 9480 14 revealed reveal VBD cord-010092-uftc8inx 9480 15 one one CD cord-010092-uftc8inx 9480 16 homozygous homozygous JJ cord-010092-uftc8inx 9480 17 nonsense nonsense NN cord-010092-uftc8inx 9480 18 mutation mutation NN cord-010092-uftc8inx 9480 19 in in IN cord-010092-uftc8inx 9480 20 exon exon NN cord-010092-uftc8inx 9480 21 4 4 CD cord-010092-uftc8inx 9480 22 ( ( -LRB- cord-010092-uftc8inx 9480 23 c.376C c.376C NNP cord-010092-uftc8inx 9481 1 > > XX cord-010092-uftc8inx 9482 1 T T NNP cord-010092-uftc8inx 9482 2 , , , cord-010092-uftc8inx 9482 3 p p NN cord-010092-uftc8inx 9482 4 . . . cord-010092-uftc8inx 9482 5 Gln126X Gln126X NNS cord-010092-uftc8inx 9482 6 ) ) -RRB- cord-010092-uftc8inx 9482 7 . . . cord-010092-uftc8inx 9483 1 After after IN cord-010092-uftc8inx 9483 2 the the DT cord-010092-uftc8inx 9483 3 delivery delivery NN cord-010092-uftc8inx 9483 4 of of IN cord-010092-uftc8inx 9483 5 the the DT cord-010092-uftc8inx 9483 6 pregnant pregnant JJ cord-010092-uftc8inx 9483 7 women woman NNS cord-010092-uftc8inx 9483 8 , , , cord-010092-uftc8inx 9483 9 no no DT cord-010092-uftc8inx 9483 10 pathological pathological JJ cord-010092-uftc8inx 9483 11 jaundice jaundice NN cord-010092-uftc8inx 9483 12 was be VBD cord-010092-uftc8inx 9483 13 seen see VBN cord-010092-uftc8inx 9483 14 in in IN cord-010092-uftc8inx 9483 15 the the DT cord-010092-uftc8inx 9483 16 newborn newborn NN cord-010092-uftc8inx 9483 17 . . . cord-010092-uftc8inx 9484 1 Summary Summary NNP cord-010092-uftc8inx 9484 2 / / SYM cord-010092-uftc8inx 9484 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 9484 4 : : : cord-010092-uftc8inx 9485 1 In in IN cord-010092-uftc8inx 9485 2 the the DT cord-010092-uftc8inx 9485 3 condition condition NN cord-010092-uftc8inx 9485 4 of of IN cord-010092-uftc8inx 9485 5 the the DT cord-010092-uftc8inx 9485 6 anti anti NNP cord-010092-uftc8inx 9485 7 - - NNP cord-010092-uftc8inx 9485 8 Jr Jr NNP cord-010092-uftc8inx 9485 9 a a DT cord-010092-uftc8inx 9485 10 reagent reagent NN cord-010092-uftc8inx 9485 11 was be VBD cord-010092-uftc8inx 9485 12 unavailable unavailable JJ cord-010092-uftc8inx 9485 13 for for IN cord-010092-uftc8inx 9485 14 the the DT cord-010092-uftc8inx 9485 15 identification identification NN cord-010092-uftc8inx 9485 16 of of IN cord-010092-uftc8inx 9485 17 Jr Jr NNP cord-010092-uftc8inx 9485 18 a a DT cord-010092-uftc8inx 9485 19 antigen antigen NN cord-010092-uftc8inx 9485 20 in in IN cord-010092-uftc8inx 9485 21 the the DT cord-010092-uftc8inx 9485 22 patient patient NN cord-010092-uftc8inx 9485 23 , , , cord-010092-uftc8inx 9485 24 having have VBG cord-010092-uftc8inx 9485 25 an an DT cord-010092-uftc8inx 9485 26 indication indication NN cord-010092-uftc8inx 9485 27 with with IN cord-010092-uftc8inx 9485 28 anti anti JJ cord-010092-uftc8inx 9485 29 - - NNP cord-010092-uftc8inx 9485 30 Jr Jr NNP cord-010092-uftc8inx 9485 31 a a DT cord-010092-uftc8inx 9485 32 by by IN cord-010092-uftc8inx 9485 33 serological serological JJ cord-010092-uftc8inx 9485 34 test test NN cord-010092-uftc8inx 9485 35 , , , cord-010092-uftc8inx 9485 36 the the DT cord-010092-uftc8inx 9485 37 alternative alternative JJ cord-010092-uftc8inx 9485 38 genotyping genotyping NN cord-010092-uftc8inx 9485 39 method method NN cord-010092-uftc8inx 9485 40 was be VBD cord-010092-uftc8inx 9485 41 used use VBN cord-010092-uftc8inx 9485 42 . . . cord-010092-uftc8inx 9486 1 The the DT cord-010092-uftc8inx 9486 2 most most RBS cord-010092-uftc8inx 9486 3 common common JJ cord-010092-uftc8inx 9486 4 silencing silence VBG cord-010092-uftc8inx 9486 5 JR JR NNP cord-010092-uftc8inx 9486 6 allele allele NN cord-010092-uftc8inx 9486 7 reported report VBN cord-010092-uftc8inx 9486 8 in in IN cord-010092-uftc8inx 9486 9 Asian asian JJ cord-010092-uftc8inx 9486 10 population population NN cord-010092-uftc8inx 9486 11 , , , cord-010092-uftc8inx 9486 12 especially especially RB cord-010092-uftc8inx 9486 13 in in IN cord-010092-uftc8inx 9486 14 Japanese japanese JJ cord-010092-uftc8inx 9486 15 population population NN cord-010092-uftc8inx 9486 16 , , , cord-010092-uftc8inx 9486 17 was be VBD cord-010092-uftc8inx 9486 18 identified identify VBN cord-010092-uftc8inx 9486 19 to to TO cord-010092-uftc8inx 9486 20 indicate indicate VB cord-010092-uftc8inx 9486 21 Jr(a- jr(a- CD cord-010092-uftc8inx 9486 22 ) ) -RRB- cord-010092-uftc8inx 9486 23 phenotype phenotype NN cord-010092-uftc8inx 9486 24 . . . cord-010092-uftc8inx 9487 1 Immunohemotherapy Immunohemotherapy NNP cord-010092-uftc8inx 9487 2 , , , cord-010092-uftc8inx 9487 3 Centro Centro NNP cord-010092-uftc8inx 9487 4 Hospitalar Hospitalar NNP cord-010092-uftc8inx 9487 5 Vila Vila NNP cord-010092-uftc8inx 9487 6 Nova Nova NNP cord-010092-uftc8inx 9487 7 de de NNP cord-010092-uftc8inx 9487 8 Gaia Gaia NNP cord-010092-uftc8inx 9487 9 / / SYM cord-010092-uftc8inx 9487 10 Espinho Espinho NNP cord-010092-uftc8inx 9487 11 , , , cord-010092-uftc8inx 9487 12 Vila Vila NNP cord-010092-uftc8inx 9487 13 Nova Nova NNP cord-010092-uftc8inx 9487 14 de de FW cord-010092-uftc8inx 9487 15 Gaia Gaia NNP cord-010092-uftc8inx 9487 16 , , , cord-010092-uftc8inx 9488 1 Portugal Portugal NNP cord-010092-uftc8inx 9488 2 Background Background NNP cord-010092-uftc8inx 9488 3 : : : cord-010092-uftc8inx 9489 1 If if IN cord-010092-uftc8inx 9489 2 the the DT cord-010092-uftc8inx 9489 3 investigation investigation NN cord-010092-uftc8inx 9489 4 of of IN cord-010092-uftc8inx 9489 5 irregular irregular JJ cord-010092-uftc8inx 9489 6 / / SYM cord-010092-uftc8inx 9489 7 unexpected unexpected JJ cord-010092-uftc8inx 9489 8 antibodies antibody NNS cord-010092-uftc8inx 9489 9 reveals reveal VBZ cord-010092-uftc8inx 9489 10 a a DT cord-010092-uftc8inx 9489 11 pattern pattern NN cord-010092-uftc8inx 9489 12 in in IN cord-010092-uftc8inx 9489 13 which which WDT cord-010092-uftc8inx 9489 14 all all DT cord-010092-uftc8inx 9489 15 or or CC cord-010092-uftc8inx 9489 16 most most JJS cord-010092-uftc8inx 9489 17 screen screen NN cord-010092-uftc8inx 9489 18 and and CC cord-010092-uftc8inx 9489 19 panel panel NN cord-010092-uftc8inx 9489 20 cells cell NNS cord-010092-uftc8inx 9489 21 are be VBP cord-010092-uftc8inx 9489 22 positive positive JJ cord-010092-uftc8inx 9489 23 , , , cord-010092-uftc8inx 9489 24 with with IN cord-010092-uftc8inx 9489 25 reactions reaction NNS cord-010092-uftc8inx 9489 26 in in IN cord-010092-uftc8inx 9489 27 the the DT cord-010092-uftc8inx 9489 28 same same JJ cord-010092-uftc8inx 9489 29 phase phase NN cord-010092-uftc8inx 9489 30 and and CC cord-010092-uftc8inx 9489 31 with with IN cord-010092-uftc8inx 9489 32 the the DT cord-010092-uftc8inx 9489 33 same same JJ cord-010092-uftc8inx 9489 34 strength strength NN cord-010092-uftc8inx 9489 35 , , , cord-010092-uftc8inx 9489 36 along along IN cord-010092-uftc8inx 9489 37 with with IN cord-010092-uftc8inx 9489 38 a a DT cord-010092-uftc8inx 9489 39 negative negative JJ cord-010092-uftc8inx 9489 40 autocontrol autocontrol NN cord-010092-uftc8inx 9489 41 , , , cord-010092-uftc8inx 9489 42 an an DT cord-010092-uftc8inx 9489 43 irregular irregular JJ cord-010092-uftc8inx 9489 44 antibody antibody NN cord-010092-uftc8inx 9489 45 to to IN cord-010092-uftc8inx 9489 46 a a DT cord-010092-uftc8inx 9489 47 high high JJ cord-010092-uftc8inx 9489 48 - - HYPH cord-010092-uftc8inx 9489 49 prevalence prevalence NN cord-010092-uftc8inx 9489 50 antigen antigen NN cord-010092-uftc8inx 9489 51 may may MD cord-010092-uftc8inx 9489 52 be be VB cord-010092-uftc8inx 9489 53 suspected suspect VBN cord-010092-uftc8inx 9489 54 . . . cord-010092-uftc8inx 9490 1 High high JJ cord-010092-uftc8inx 9490 2 - - HYPH cord-010092-uftc8inx 9490 3 prevalence prevalence NN cord-010092-uftc8inx 9490 4 antigens antigen NNS cord-010092-uftc8inx 9490 5 are be VBP cord-010092-uftc8inx 9490 6 those those DT cord-010092-uftc8inx 9490 7 that that WDT cord-010092-uftc8inx 9490 8 are be VBP cord-010092-uftc8inx 9490 9 present present JJ cord-010092-uftc8inx 9490 10 in in IN cord-010092-uftc8inx 9490 11 almost almost RB cord-010092-uftc8inx 9490 12 all all DT cord-010092-uftc8inx 9490 13 individuals individual NNS cord-010092-uftc8inx 9490 14 ( ( -LRB- cord-010092-uftc8inx 9490 15 98 98 CD cord-010092-uftc8inx 9490 16 % % NN cord-010092-uftc8inx 9490 17 or or CC cord-010092-uftc8inx 9490 18 more more JJR cord-010092-uftc8inx 9490 19 ) ) -RRB- cord-010092-uftc8inx 9490 20 . . . cord-010092-uftc8inx 9491 1 Fortunately fortunately RB cord-010092-uftc8inx 9491 2 , , , cord-010092-uftc8inx 9491 3 because because IN cord-010092-uftc8inx 9491 4 these these DT cord-010092-uftc8inx 9491 5 antigens antigen NNS cord-010092-uftc8inx 9491 6 do do VBP cord-010092-uftc8inx 9491 7 occur occur VB cord-010092-uftc8inx 9491 8 so so RB cord-010092-uftc8inx 9491 9 frequently frequently RB cord-010092-uftc8inx 9491 10 , , , cord-010092-uftc8inx 9491 11 it -PRON- PRP cord-010092-uftc8inx 9491 12 is be VBZ cord-010092-uftc8inx 9491 13 not not RB cord-010092-uftc8inx 9491 14 common common JJ cord-010092-uftc8inx 9491 15 to to TO cord-010092-uftc8inx 9491 16 find find VB cord-010092-uftc8inx 9491 17 a a DT cord-010092-uftc8inx 9491 18 patient patient NN cord-010092-uftc8inx 9491 19 with with IN cord-010092-uftc8inx 9491 20 an an DT cord-010092-uftc8inx 9491 21 antibody antibody NN cord-010092-uftc8inx 9491 22 to to IN cord-010092-uftc8inx 9491 23 one one CD cord-010092-uftc8inx 9491 24 of of IN cord-010092-uftc8inx 9491 25 them -PRON- PRP cord-010092-uftc8inx 9491 26 . . . cord-010092-uftc8inx 9492 1 However however RB cord-010092-uftc8inx 9492 2 , , , cord-010092-uftc8inx 9492 3 when when WRB cord-010092-uftc8inx 9492 4 it -PRON- PRP cord-010092-uftc8inx 9492 5 happens happen VBZ cord-010092-uftc8inx 9492 6 , , , cord-010092-uftc8inx 9492 7 it -PRON- PRP cord-010092-uftc8inx 9492 8 may may MD cord-010092-uftc8inx 9492 9 become become VB cord-010092-uftc8inx 9492 10 a a DT cord-010092-uftc8inx 9492 11 troubling troubling JJ cord-010092-uftc8inx 9492 12 situation situation NN cord-010092-uftc8inx 9492 13 . . . cord-010092-uftc8inx 9493 1 Aims aim VBZ cord-010092-uftc8inx 9493 2 : : : cord-010092-uftc8inx 9493 3 Clinical clinical JJ cord-010092-uftc8inx 9493 4 case case NN cord-010092-uftc8inx 9493 5 report report NN cord-010092-uftc8inx 9493 6 of of IN cord-010092-uftc8inx 9493 7 panagglutination panagglutination NN cord-010092-uftc8inx 9493 8 in in IN cord-010092-uftc8inx 9493 9 assessment assessment NN cord-010092-uftc8inx 9493 10 of of IN cord-010092-uftc8inx 9493 11 irregular irregular JJ cord-010092-uftc8inx 9493 12 antibodies antibody NNS cord-010092-uftc8inx 9493 13 . . . cord-010092-uftc8inx 9494 1 Methods method NNS cord-010092-uftc8inx 9494 2 : : : cord-010092-uftc8inx 9494 3 Collection collection NN cord-010092-uftc8inx 9494 4 of of IN cord-010092-uftc8inx 9494 5 clinical clinical JJ cord-010092-uftc8inx 9494 6 data datum NNS cord-010092-uftc8inx 9494 7 in in IN cord-010092-uftc8inx 9494 8 SCl SCl NNP cord-010092-uftc8inx 9494 9 ınico ınico NNP cord-010092-uftc8inx 9494 10 â â , cord-010092-uftc8inx 9494 11 and and CC cord-010092-uftc8inx 9494 12 Sibas Sibas NNP cord-010092-uftc8inx 9494 13 â â NNP cord-010092-uftc8inx 9494 14 applications application NNS cord-010092-uftc8inx 9494 15 . . . cord-010092-uftc8inx 9495 1 Results result NNS cord-010092-uftc8inx 9495 2 : : : cord-010092-uftc8inx 9496 1 Woman woman NN cord-010092-uftc8inx 9496 2 , , , cord-010092-uftc8inx 9496 3 76 76 CD cord-010092-uftc8inx 9496 4 years year NNS cord-010092-uftc8inx 9496 5 old old JJ cord-010092-uftc8inx 9496 6 , , , cord-010092-uftc8inx 9496 7 O o UH cord-010092-uftc8inx 9496 8 RhD+ RhD+ NNP cord-010092-uftc8inx 9496 9 , , , cord-010092-uftc8inx 9496 10 previously previously RB cord-010092-uftc8inx 9496 11 transfused transfuse VBN cord-010092-uftc8inx 9496 12 with with IN cord-010092-uftc8inx 9496 13 4 4 CD cord-010092-uftc8inx 9496 14 red red JJ cord-010092-uftc8inx 9496 15 blood blood NN cord-010092-uftc8inx 9496 16 cells cell NNS cord-010092-uftc8inx 9496 17 concentrates concentrate VBZ cord-010092-uftc8inx 9496 18 in in IN cord-010092-uftc8inx 9496 19 2006 2006 CD cord-010092-uftc8inx 9496 20 , , , cord-010092-uftc8inx 9496 21 was be VBD cord-010092-uftc8inx 9496 22 proposed propose VBN cord-010092-uftc8inx 9496 23 to to IN cord-010092-uftc8inx 9496 24 a a DT cord-010092-uftc8inx 9496 25 correction correction NN cord-010092-uftc8inx 9496 26 surgery surgery NN cord-010092-uftc8inx 9496 27 of of IN cord-010092-uftc8inx 9496 28 a a DT cord-010092-uftc8inx 9496 29 periprosthetic periprosthetic JJ cord-010092-uftc8inx 9496 30 hip hip NN cord-010092-uftc8inx 9496 31 fracture fracture NN cord-010092-uftc8inx 9496 32 . . . cord-010092-uftc8inx 9497 1 Pretransfusion Pretransfusion NNP cord-010092-uftc8inx 9497 2 serologic serologic NN cord-010092-uftc8inx 9497 3 tests test NNS cord-010092-uftc8inx 9497 4 were be VBD cord-010092-uftc8inx 9497 5 requested request VBN cord-010092-uftc8inx 9497 6 and and CC cord-010092-uftc8inx 9497 7 irregular irregular JJ cord-010092-uftc8inx 9497 8 antibodies antibody NNS cord-010092-uftc8inx 9497 9 were be VBD cord-010092-uftc8inx 9497 10 detected detect VBN cord-010092-uftc8inx 9497 11 ( ( -LRB- cord-010092-uftc8inx 9497 12 2 2 CD cord-010092-uftc8inx 9497 13 + + SYM cord-010092-uftc8inx 9497 14 in in IN cord-010092-uftc8inx 9497 15 all all PDT cord-010092-uftc8inx 9497 16 the the DT cord-010092-uftc8inx 9497 17 3 3 CD cord-010092-uftc8inx 9497 18 screening screening NN cord-010092-uftc8inx 9497 19 cells cell NNS cord-010092-uftc8inx 9497 20 ) ) -RRB- cord-010092-uftc8inx 9497 21 . . . cord-010092-uftc8inx 9498 1 In in IN cord-010092-uftc8inx 9498 2 order order NN cord-010092-uftc8inx 9498 3 to to TO cord-010092-uftc8inx 9498 4 identify identify VB cord-010092-uftc8inx 9498 5 the the DT cord-010092-uftc8inx 9498 6 specificity specificity NN cord-010092-uftc8inx 9498 7 of of IN cord-010092-uftc8inx 9498 8 the the DT cord-010092-uftc8inx 9498 9 antibody antibody NN cord-010092-uftc8inx 9498 10 , , , cord-010092-uftc8inx 9498 11 a a DT cord-010092-uftc8inx 9498 12 panel panel NN cord-010092-uftc8inx 9498 13 of of IN cord-010092-uftc8inx 9498 14 11 11 CD cord-010092-uftc8inx 9498 15 cells cell NNS cord-010092-uftc8inx 9498 16 was be VBD cord-010092-uftc8inx 9498 17 tested test VBN cord-010092-uftc8inx 9498 18 ; ; : cord-010092-uftc8inx 9498 19 the the DT cord-010092-uftc8inx 9498 20 result result NN cord-010092-uftc8inx 9498 21 was be VBD cord-010092-uftc8inx 9498 22 considered consider VBN cord-010092-uftc8inx 9498 23 inconclusive inconclusive JJ cord-010092-uftc8inx 9498 24 , , , cord-010092-uftc8inx 9498 25 due due IN cord-010092-uftc8inx 9498 26 to to IN cord-010092-uftc8inx 9498 27 positive positive JJ cord-010092-uftc8inx 9498 28 reactions reaction NNS cord-010092-uftc8inx 9498 29 ( ( -LRB- cord-010092-uftc8inx 9498 30 2 2 CD cord-010092-uftc8inx 9498 31 + + SYM cord-010092-uftc8inx 9498 32 ) ) -RRB- cord-010092-uftc8inx 9498 33 with with IN cord-010092-uftc8inx 9498 34 all all DT cord-010092-uftc8inx 9498 35 test test NN cord-010092-uftc8inx 9498 36 cells cell NNS cord-010092-uftc8inx 9498 37 in in IN cord-010092-uftc8inx 9498 38 LISS LISS NNP cord-010092-uftc8inx 9498 39 / / SYM cord-010092-uftc8inx 9498 40 Coombs Coombs NNP cord-010092-uftc8inx 9498 41 and and CC cord-010092-uftc8inx 9498 42 atypical atypical JJ cord-010092-uftc8inx 9498 43 positivity positivity NN cord-010092-uftc8inx 9498 44 with with IN cord-010092-uftc8inx 9498 45 dragging drag VBG cord-010092-uftc8inx 9498 46 in in IN cord-010092-uftc8inx 9498 47 all all DT cord-010092-uftc8inx 9498 48 cells cell NNS cord-010092-uftc8inx 9498 49 in in IN cord-010092-uftc8inx 9498 50 enzymatic enzymatic JJ cord-010092-uftc8inx 9498 51 environment environment NN cord-010092-uftc8inx 9498 52 . . . cord-010092-uftc8inx 9499 1 Autocontrol Autocontrol NNP cord-010092-uftc8inx 9499 2 and and CC cord-010092-uftc8inx 9499 3 direct direct JJ cord-010092-uftc8inx 9499 4 antiglobulin antiglobulin NN cord-010092-uftc8inx 9499 5 test test NN cord-010092-uftc8inx 9499 6 were be VBD cord-010092-uftc8inx 9499 7 negative negative JJ cord-010092-uftc8inx 9499 8 . . . cord-010092-uftc8inx 9500 1 It -PRON- PRP cord-010092-uftc8inx 9500 2 was be VBD cord-010092-uftc8inx 9500 3 decided decide VBN cord-010092-uftc8inx 9500 4 to to TO cord-010092-uftc8inx 9500 5 send send VB cord-010092-uftc8inx 9500 6 two two CD cord-010092-uftc8inx 9500 7 blood blood NN cord-010092-uftc8inx 9500 8 samples sample NNS cord-010092-uftc8inx 9500 9 to to IN cord-010092-uftc8inx 9500 10 the the DT cord-010092-uftc8inx 9500 11 reference reference NN cord-010092-uftc8inx 9500 12 laboratory laboratory NN cord-010092-uftc8inx 9500 13 for for IN cord-010092-uftc8inx 9500 14 a a DT cord-010092-uftc8inx 9500 15 more more RBR cord-010092-uftc8inx 9500 16 complete complete JJ cord-010092-uftc8inx 9500 17 immunohematological immunohematological JJ cord-010092-uftc8inx 9500 18 study study NN cord-010092-uftc8inx 9500 19 . . . cord-010092-uftc8inx 9501 1 Compatibilization Compatibilization NNP cord-010092-uftc8inx 9501 2 of of IN cord-010092-uftc8inx 9501 3 red red JJ cord-010092-uftc8inx 9501 4 blood blood NN cord-010092-uftc8inx 9501 5 cells cell NNS cord-010092-uftc8inx 9501 6 to to IN cord-010092-uftc8inx 9501 7 this this DT cord-010092-uftc8inx 9501 8 patient patient NN cord-010092-uftc8inx 9501 9 was be VBD cord-010092-uftc8inx 9501 10 also also RB cord-010092-uftc8inx 9501 11 requested request VBN cord-010092-uftc8inx 9501 12 . . . cord-010092-uftc8inx 9502 1 During during IN cord-010092-uftc8inx 9502 2 the the DT cord-010092-uftc8inx 9502 3 waiting waiting NN cord-010092-uftc8inx 9502 4 period period NN cord-010092-uftc8inx 9502 5 , , , cord-010092-uftc8inx 9502 6 haematopoiesis haematopoiesis NN cord-010092-uftc8inx 9502 7 was be VBD cord-010092-uftc8inx 9502 8 optimized optimize VBN cord-010092-uftc8inx 9502 9 . . . cord-010092-uftc8inx 9503 1 Although although IN cord-010092-uftc8inx 9503 2 the the DT cord-010092-uftc8inx 9503 3 patient patient NN cord-010092-uftc8inx 9503 4 did do VBD cord-010092-uftc8inx 9503 5 not not RB cord-010092-uftc8inx 9503 6 present present VB cord-010092-uftc8inx 9503 7 anaemia anaemia NN cord-010092-uftc8inx 9503 8 at at IN cord-010092-uftc8inx 9503 9 admission admission NN cord-010092-uftc8inx 9503 10 , , , cord-010092-uftc8inx 9503 11 the the DT cord-010092-uftc8inx 9503 12 analytical analytical JJ cord-010092-uftc8inx 9503 13 study study NN cord-010092-uftc8inx 9503 14 revealed reveal VBD cord-010092-uftc8inx 9503 15 iron iron NN cord-010092-uftc8inx 9503 16 deficiency deficiency NN cord-010092-uftc8inx 9503 17 ; ; : cord-010092-uftc8inx 9503 18 therefore therefore RB cord-010092-uftc8inx 9503 19 , , , cord-010092-uftc8inx 9503 20 supplementation supplementation NN cord-010092-uftc8inx 9503 21 with with IN cord-010092-uftc8inx 9503 22 intravenous intravenous JJ cord-010092-uftc8inx 9503 23 iron iron NN cord-010092-uftc8inx 9503 24 was be VBD cord-010092-uftc8inx 9503 25 performed perform VBN cord-010092-uftc8inx 9503 26 . . . cord-010092-uftc8inx 9504 1 The the DT cord-010092-uftc8inx 9504 2 reference reference NN cord-010092-uftc8inx 9504 3 laboratory laboratory NN cord-010092-uftc8inx 9504 4 also also RB cord-010092-uftc8inx 9504 5 obtained obtain VBD cord-010092-uftc8inx 9504 6 a a DT cord-010092-uftc8inx 9504 7 panreactive panreactive JJ cord-010092-uftc8inx 9504 8 panel panel NN cord-010092-uftc8inx 9504 9 ( ( -LRB- cord-010092-uftc8inx 9504 10 2 2 CD cord-010092-uftc8inx 9504 11 + + SYM cord-010092-uftc8inx 9504 12 with with IN cord-010092-uftc8inx 9504 13 all all DT cord-010092-uftc8inx 9504 14 cells cell NNS cord-010092-uftc8inx 9504 15 ) ) -RRB- cord-010092-uftc8inx 9504 16 in in IN cord-010092-uftc8inx 9504 17 LISS LISS NNP cord-010092-uftc8inx 9504 18 / / SYM cord-010092-uftc8inx 9504 19 Coombs Coombs NNP cord-010092-uftc8inx 9504 20 and and CC cord-010092-uftc8inx 9504 21 weak weak JJ cord-010092-uftc8inx 9504 22 positivity positivity NN cord-010092-uftc8inx 9504 23 in in IN cord-010092-uftc8inx 9504 24 papain papain NN cord-010092-uftc8inx 9504 25 . . . cord-010092-uftc8inx 9505 1 After after IN cord-010092-uftc8inx 9505 2 allo allo NN cord-010092-uftc8inx 9505 3 - - HYPH cord-010092-uftc8inx 9505 4 adsorption adsorption NN cord-010092-uftc8inx 9505 5 , , , cord-010092-uftc8inx 9505 6 the the DT cord-010092-uftc8inx 9505 7 search search NN cord-010092-uftc8inx 9505 8 for for IN cord-010092-uftc8inx 9505 9 irregular irregular JJ cord-010092-uftc8inx 9505 10 antibodies antibody NNS cord-010092-uftc8inx 9505 11 was be VBD cord-010092-uftc8inx 9505 12 negative negative JJ cord-010092-uftc8inx 9505 13 . . . cord-010092-uftc8inx 9506 1 An an DT cord-010092-uftc8inx 9506 2 anti anti NN cord-010092-uftc8inx 9506 3 - - NN cord-010092-uftc8inx 9506 4 Yt Yt NNP cord-010092-uftc8inx 9506 5 a a DT cord-010092-uftc8inx 9506 6 , , , cord-010092-uftc8inx 9506 7 apparently apparently RB cord-010092-uftc8inx 9506 8 without without IN cord-010092-uftc8inx 9506 9 clinical clinical JJ cord-010092-uftc8inx 9506 10 significance significance NN cord-010092-uftc8inx 9506 11 ( ( -LRB- cord-010092-uftc8inx 9506 12 negative negative JJ cord-010092-uftc8inx 9506 13 IgG1 igg1 NN cord-010092-uftc8inx 9506 14 and and CC cord-010092-uftc8inx 9506 15 IgG3 IgG3 NNP cord-010092-uftc8inx 9506 16 ) ) -RRB- cord-010092-uftc8inx 9506 17 was be VBD cord-010092-uftc8inx 9506 18 then then RB cord-010092-uftc8inx 9506 19 identified identify VBN cord-010092-uftc8inx 9506 20 . . . cord-010092-uftc8inx 9507 1 Transfusion transfusion NN cord-010092-uftc8inx 9507 2 was be VBD cord-010092-uftc8inx 9507 3 not not RB cord-010092-uftc8inx 9507 4 needed need VBN cord-010092-uftc8inx 9507 5 either either CC cord-010092-uftc8inx 9507 6 during during IN cord-010092-uftc8inx 9507 7 or or CC cord-010092-uftc8inx 9507 8 after after IN cord-010092-uftc8inx 9507 9 the the DT cord-010092-uftc8inx 9507 10 surgery surgery NN cord-010092-uftc8inx 9507 11 , , , cord-010092-uftc8inx 9507 12 with with IN cord-010092-uftc8inx 9507 13 a a DT cord-010092-uftc8inx 9507 14 good good JJ cord-010092-uftc8inx 9507 15 recovery recovery NN cord-010092-uftc8inx 9507 16 of of IN cord-010092-uftc8inx 9507 17 the the DT cord-010092-uftc8inx 9507 18 haemoglobin haemoglobin NN cord-010092-uftc8inx 9507 19 value value NN cord-010092-uftc8inx 9507 20 in in IN cord-010092-uftc8inx 9507 21 the the DT cord-010092-uftc8inx 9507 22 postoperative postoperative JJ cord-010092-uftc8inx 9507 23 period period NN cord-010092-uftc8inx 9507 24 . . . cord-010092-uftc8inx 9508 1 Summary Summary NNP cord-010092-uftc8inx 9508 2 / / SYM cord-010092-uftc8inx 9508 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 9508 4 : : : cord-010092-uftc8inx 9509 1 Yt Yt NNP cord-010092-uftc8inx 9509 2 a a DT cord-010092-uftc8inx 9509 3 , , , cord-010092-uftc8inx 9509 4 which which WDT cord-010092-uftc8inx 9509 5 belongs belong VBZ cord-010092-uftc8inx 9509 6 to to IN cord-010092-uftc8inx 9509 7 Cartwright Cartwright NNP cord-010092-uftc8inx 9509 8 system system NN cord-010092-uftc8inx 9509 9 , , , cord-010092-uftc8inx 9509 10 is be VBZ cord-010092-uftc8inx 9509 11 a a DT cord-010092-uftc8inx 9509 12 high high JJ cord-010092-uftc8inx 9509 13 - - HYPH cord-010092-uftc8inx 9509 14 prevalence prevalence NN cord-010092-uftc8inx 9509 15 antigen antigen NN cord-010092-uftc8inx 9509 16 in in IN cord-010092-uftc8inx 9509 17 all all DT cord-010092-uftc8inx 9509 18 populations population NNS cord-010092-uftc8inx 9509 19 . . . cord-010092-uftc8inx 9510 1 Anti Anti NNP cord-010092-uftc8inx 9510 2 - - NNP cord-010092-uftc8inx 9510 3 Yt Yt NNP cord-010092-uftc8inx 9510 4 a a NNP cord-010092-uftc8inx 9510 5 , , , cord-010092-uftc8inx 9510 6 an an DT cord-010092-uftc8inx 9510 7 IgG igg NN cord-010092-uftc8inx 9510 8 antibody antibody NN cord-010092-uftc8inx 9510 9 stimulated stimulate VBN cord-010092-uftc8inx 9510 10 by by IN cord-010092-uftc8inx 9510 11 pregnancy pregnancy NN cord-010092-uftc8inx 9510 12 or or CC cord-010092-uftc8inx 9510 13 transfusion transfusion NN cord-010092-uftc8inx 9510 14 , , , cord-010092-uftc8inx 9510 15 is be VBZ cord-010092-uftc8inx 9510 16 not not RB cord-010092-uftc8inx 9510 17 as as RB cord-010092-uftc8inx 9510 18 uncommon uncommon JJ cord-010092-uftc8inx 9510 19 as as IN cord-010092-uftc8inx 9510 20 we -PRON- PRP cord-010092-uftc8inx 9510 21 may may MD cord-010092-uftc8inx 9510 22 think think VB cord-010092-uftc8inx 9510 23 , , , cord-010092-uftc8inx 9510 24 which which WDT cord-010092-uftc8inx 9510 25 suggests suggest VBZ cord-010092-uftc8inx 9510 26 that that IN cord-010092-uftc8inx 9510 27 it -PRON- PRP cord-010092-uftc8inx 9510 28 is be VBZ cord-010092-uftc8inx 9510 29 reasonably reasonably RB cord-010092-uftc8inx 9510 30 immunogenic immunogenic JJ cord-010092-uftc8inx 9510 31 . . . cord-010092-uftc8inx 9511 1 These these DT cord-010092-uftc8inx 9511 2 antibodies antibody NNS cord-010092-uftc8inx 9511 3 are be VBP cord-010092-uftc8inx 9511 4 not not RB cord-010092-uftc8inx 9511 5 generally generally RB cord-010092-uftc8inx 9511 6 considered consider VBN cord-010092-uftc8inx 9511 7 clinically clinically RB cord-010092-uftc8inx 9511 8 significant significant JJ cord-010092-uftc8inx 9511 9 , , , cord-010092-uftc8inx 9511 10 but but CC cord-010092-uftc8inx 9511 11 there there EX cord-010092-uftc8inx 9511 12 are be VBP cord-010092-uftc8inx 9511 13 reported report VBN cord-010092-uftc8inx 9511 14 cases case NNS cord-010092-uftc8inx 9511 15 of of IN cord-010092-uftc8inx 9511 16 acute acute JJ cord-010092-uftc8inx 9511 17 and and CC cord-010092-uftc8inx 9511 18 delayed delay VBN cord-010092-uftc8inx 9511 19 haemolytic haemolytic JJ cord-010092-uftc8inx 9511 20 transfusion transfusion NN cord-010092-uftc8inx 9511 21 reactions reaction NNS cord-010092-uftc8inx 9511 22 in in IN cord-010092-uftc8inx 9511 23 which which WDT cord-010092-uftc8inx 9511 24 anti anti NNS cord-010092-uftc8inx 9511 25 - - NNP cord-010092-uftc8inx 9511 26 Yt Yt NNP cord-010092-uftc8inx 9511 27 a a DT cord-010092-uftc8inx 9511 28 has have VBZ cord-010092-uftc8inx 9511 29 been be VBN cord-010092-uftc8inx 9511 30 implicated implicate VBN cord-010092-uftc8inx 9511 31 . . . cord-010092-uftc8inx 9512 1 Therefore therefore RB cord-010092-uftc8inx 9512 2 , , , cord-010092-uftc8inx 9512 3 although although IN cord-010092-uftc8inx 9512 4 the the DT cord-010092-uftc8inx 9512 5 described describe VBN cord-010092-uftc8inx 9512 6 pattern pattern NN cord-010092-uftc8inx 9512 7 of of IN cord-010092-uftc8inx 9512 8 panagglutination panagglutination NN cord-010092-uftc8inx 9512 9 in in IN cord-010092-uftc8inx 9512 10 assessment assessment NN cord-010092-uftc8inx 9512 11 of of IN cord-010092-uftc8inx 9512 12 irregular irregular JJ cord-010092-uftc8inx 9512 13 antibodies antibody NNS cord-010092-uftc8inx 9512 14 may may MD cord-010092-uftc8inx 9512 15 suggest suggest VB cord-010092-uftc8inx 9512 16 the the DT cord-010092-uftc8inx 9512 17 presence presence NN cord-010092-uftc8inx 9512 18 of of IN cord-010092-uftc8inx 9512 19 an an DT cord-010092-uftc8inx 9512 20 alloantibody alloantibody NN cord-010092-uftc8inx 9512 21 directed direct VBN cord-010092-uftc8inx 9512 22 against against IN cord-010092-uftc8inx 9512 23 a a DT cord-010092-uftc8inx 9512 24 highfrequency highfrequency NN cord-010092-uftc8inx 9512 25 antigen antigen NN cord-010092-uftc8inx 9512 26 , , , cord-010092-uftc8inx 9512 27 it -PRON- PRP cord-010092-uftc8inx 9512 28 is be VBZ cord-010092-uftc8inx 9512 29 very very RB cord-010092-uftc8inx 9512 30 important important JJ cord-010092-uftc8inx 9512 31 to to TO cord-010092-uftc8inx 9512 32 confirm confirm VB cord-010092-uftc8inx 9512 33 that that DT cord-010092-uftc8inx 9512 34 hypothesis hypothesis NN cord-010092-uftc8inx 9512 35 , , , cord-010092-uftc8inx 9512 36 recurring recur VBG cord-010092-uftc8inx 9512 37 to to IN cord-010092-uftc8inx 9512 38 a a DT cord-010092-uftc8inx 9512 39 reference reference NN cord-010092-uftc8inx 9512 40 laboratory laboratory NN cord-010092-uftc8inx 9512 41 if if IN cord-010092-uftc8inx 9512 42 necessary necessary JJ cord-010092-uftc8inx 9512 43 , , , cord-010092-uftc8inx 9512 44 to to TO cord-010092-uftc8inx 9512 45 identify identify VB cord-010092-uftc8inx 9512 46 the the DT cord-010092-uftc8inx 9512 47 antibody antibody NN cord-010092-uftc8inx 9512 48 and and CC cord-010092-uftc8inx 9512 49 to to TO cord-010092-uftc8inx 9512 50 determine determine VB cord-010092-uftc8inx 9512 51 its -PRON- PRP$ cord-010092-uftc8inx 9512 52 clinical clinical JJ cord-010092-uftc8inx 9512 53 relevance relevance NN cord-010092-uftc8inx 9512 54 . . . cord-010092-uftc8inx 9513 1 Even even RB cord-010092-uftc8inx 9513 2 if if IN cord-010092-uftc8inx 9513 3 the the DT cord-010092-uftc8inx 9513 4 identified identify VBN cord-010092-uftc8inx 9513 5 antibody antibody NN cord-010092-uftc8inx 9513 6 is be VBZ cord-010092-uftc8inx 9513 7 associated associate VBN cord-010092-uftc8inx 9513 8 with with IN cord-010092-uftc8inx 9513 9 rare rare JJ cord-010092-uftc8inx 9513 10 haemolytic haemolytic JJ cord-010092-uftc8inx 9513 11 transfusion transfusion NN cord-010092-uftc8inx 9513 12 reactions reaction NNS cord-010092-uftc8inx 9513 13 , , , cord-010092-uftc8inx 9513 14 it -PRON- PRP cord-010092-uftc8inx 9513 15 is be VBZ cord-010092-uftc8inx 9513 16 crucial crucial JJ cord-010092-uftc8inx 9513 17 to to TO cord-010092-uftc8inx 9513 18 optimize optimize VB cord-010092-uftc8inx 9513 19 haematopoiesis haematopoiesis NN cord-010092-uftc8inx 9513 20 when when WRB cord-010092-uftc8inx 9513 21 it -PRON- PRP cord-010092-uftc8inx 9513 22 is be VBZ cord-010092-uftc8inx 9513 23 not not RB cord-010092-uftc8inx 9513 24 an an DT cord-010092-uftc8inx 9513 25 emergent emergent JJ cord-010092-uftc8inx 9513 26 procedure procedure NN cord-010092-uftc8inx 9513 27 , , , cord-010092-uftc8inx 9513 28 in in IN cord-010092-uftc8inx 9513 29 order order NN cord-010092-uftc8inx 9513 30 to to TO cord-010092-uftc8inx 9513 31 minimize minimize VB cord-010092-uftc8inx 9513 32 transfusion transfusion NN cord-010092-uftc8inx 9513 33 and and CC cord-010092-uftc8inx 9513 34 its -PRON- PRP$ cord-010092-uftc8inx 9513 35 associated associate VBN cord-010092-uftc8inx 9513 36 risks risk NNS cord-010092-uftc8inx 9513 37 . . . cord-010092-uftc8inx 9514 1 Both both DT cord-010092-uftc8inx 9514 2 for for IN cord-010092-uftc8inx 9514 3 emergent emergent JJ cord-010092-uftc8inx 9514 4 and and CC cord-010092-uftc8inx 9514 5 elective elective JJ cord-010092-uftc8inx 9514 6 procedures procedure NNS cord-010092-uftc8inx 9514 7 , , , cord-010092-uftc8inx 9514 8 the the DT cord-010092-uftc8inx 9514 9 creation creation NN cord-010092-uftc8inx 9514 10 of of IN cord-010092-uftc8inx 9514 11 a a DT cord-010092-uftc8inx 9514 12 national national JJ cord-010092-uftc8inx 9514 13 database database NN cord-010092-uftc8inx 9514 14 of of IN cord-010092-uftc8inx 9514 15 patients patient NNS cord-010092-uftc8inx 9514 16 with with IN cord-010092-uftc8inx 9514 17 already already RB cord-010092-uftc8inx 9514 18 identified identify VBN cord-010092-uftc8inx 9514 19 irregular irregular JJ cord-010092-uftc8inx 9514 20 antibodies antibody NNS cord-010092-uftc8inx 9514 21 would would MD cord-010092-uftc8inx 9514 22 facilitate facilitate VB cord-010092-uftc8inx 9514 23 the the DT cord-010092-uftc8inx 9514 24 administration administration NN cord-010092-uftc8inx 9514 25 of of IN cord-010092-uftc8inx 9514 26 red red JJ cord-010092-uftc8inx 9514 27 cells cell NNS cord-010092-uftc8inx 9514 28 concentrates concentrate VBZ cord-010092-uftc8inx 9514 29 without without IN cord-010092-uftc8inx 9514 30 the the DT cord-010092-uftc8inx 9514 31 implicated implicate VBN cord-010092-uftc8inx 9514 32 antigen antigen NN cord-010092-uftc8inx 9514 33 . . . cord-010092-uftc8inx 9515 1 Aims aim VBZ cord-010092-uftc8inx 9515 2 : : : cord-010092-uftc8inx 9516 1 To to TO cord-010092-uftc8inx 9516 2 investigate investigate VB cord-010092-uftc8inx 9516 3 the the DT cord-010092-uftc8inx 9516 4 frequency frequency NN cord-010092-uftc8inx 9516 5 and and CC cord-010092-uftc8inx 9516 6 explore explore VB cord-010092-uftc8inx 9516 7 the the DT cord-010092-uftc8inx 9516 8 genomic genomic JJ cord-010092-uftc8inx 9516 9 characterization characterization NN cord-010092-uftc8inx 9516 10 of of IN cord-010092-uftc8inx 9516 11 Jk Jk NNP cord-010092-uftc8inx 9516 12 ( ( -LRB- cord-010092-uftc8inx 9516 13 a a RB cord-010092-uftc8inx 9516 14 - - HYPH cord-010092-uftc8inx 9516 15 b- b- NN cord-010092-uftc8inx 9516 16 ) ) -RRB- cord-010092-uftc8inx 9516 17 phenotype phenotype NN cord-010092-uftc8inx 9516 18 in in IN cord-010092-uftc8inx 9516 19 blood blood NN cord-010092-uftc8inx 9516 20 donors donor NNS cord-010092-uftc8inx 9516 21 in in IN cord-010092-uftc8inx 9516 22 Harbin Harbin NNP cord-010092-uftc8inx 9516 23 , , , cord-010092-uftc8inx 9516 24 China China NNP cord-010092-uftc8inx 9516 25 . . . cord-010092-uftc8inx 9517 1 Methods method NNS cord-010092-uftc8inx 9517 2 : : : cord-010092-uftc8inx 9518 1 All all DT cord-010092-uftc8inx 9518 2 samples sample NNS cord-010092-uftc8inx 9518 3 were be VBD cord-010092-uftc8inx 9518 4 screened screen VBN cord-010092-uftc8inx 9518 5 for for IN cord-010092-uftc8inx 9518 6 Jk(a Jk(a NNP cord-010092-uftc8inx 9518 7 - - HYPH cord-010092-uftc8inx 9518 8 b- b- NNP cord-010092-uftc8inx 9518 9 ) ) -RRB- cord-010092-uftc8inx 9518 10 phenotype phenotype NN cord-010092-uftc8inx 9518 11 using use VBG cord-010092-uftc8inx 9518 12 a a DT cord-010092-uftc8inx 9518 13 direct direct JJ cord-010092-uftc8inx 9518 14 urea urea NN cord-010092-uftc8inx 9518 15 lysis lysis NN cord-010092-uftc8inx 9518 16 test test NN cord-010092-uftc8inx 9518 17 . . . cord-010092-uftc8inx 9519 1 And and CC cord-010092-uftc8inx 9519 2 the the DT cord-010092-uftc8inx 9519 3 results result NNS cord-010092-uftc8inx 9519 4 were be VBD cord-010092-uftc8inx 9519 5 confirmed confirm VBN cord-010092-uftc8inx 9519 6 with with IN cord-010092-uftc8inx 9519 7 by by IN cord-010092-uftc8inx 9519 8 IAT IAT NNP cord-010092-uftc8inx 9519 9 using use VBG cord-010092-uftc8inx 9519 10 anti anti JJ cord-010092-uftc8inx 9519 11 - - NNP cord-010092-uftc8inx 9519 12 Jka jka JJ cord-010092-uftc8inx 9519 13 and and CC cord-010092-uftc8inx 9519 14 anti anti JJ cord-010092-uftc8inx 9519 15 - - NN cord-010092-uftc8inx 9519 16 Jkb Jkb NNP cord-010092-uftc8inx 9519 17 with with IN cord-010092-uftc8inx 9519 18 a a DT cord-010092-uftc8inx 9519 19 standard standard JJ cord-010092-uftc8inx 9519 20 tube tube NN cord-010092-uftc8inx 9519 21 test test NN cord-010092-uftc8inx 9519 22 . . . cord-010092-uftc8inx 9520 1 Additionally additionally RB cord-010092-uftc8inx 9520 2 , , , cord-010092-uftc8inx 9520 3 polymerase polymerase NN cord-010092-uftc8inx 9520 4 chain chain NN cord-010092-uftc8inx 9520 5 reaction reaction NN cord-010092-uftc8inx 9520 6 amplification amplification NN cord-010092-uftc8inx 9520 7 and and CC cord-010092-uftc8inx 9520 8 sequence sequence NN cord-010092-uftc8inx 9520 9 analysis analysis NN cord-010092-uftc8inx 9520 10 of of IN cord-010092-uftc8inx 9520 11 the the DT cord-010092-uftc8inx 9520 12 JK JK NNP cord-010092-uftc8inx 9520 13 gene gene NN cord-010092-uftc8inx 9520 14 were be VBD cord-010092-uftc8inx 9520 15 performed perform VBN cord-010092-uftc8inx 9520 16 . . . cord-010092-uftc8inx 9521 1 Results result NNS cord-010092-uftc8inx 9521 2 : : : cord-010092-uftc8inx 9522 1 From from IN cord-010092-uftc8inx 9522 2 80865 80865 CD cord-010092-uftc8inx 9522 3 blood blood NN cord-010092-uftc8inx 9522 4 samples sample NNS cord-010092-uftc8inx 9522 5 , , , cord-010092-uftc8inx 9522 6 four four CD cord-010092-uftc8inx 9522 7 donors donor NNS cord-010092-uftc8inx 9522 8 with with IN cord-010092-uftc8inx 9522 9 Jk Jk NNP cord-010092-uftc8inx 9522 10 ( ( -LRB- cord-010092-uftc8inx 9522 11 a a RB cord-010092-uftc8inx 9522 12 - - HYPH cord-010092-uftc8inx 9522 13 b- b- NN cord-010092-uftc8inx 9522 14 ) ) -RRB- cord-010092-uftc8inx 9522 15 were be VBD cord-010092-uftc8inx 9522 16 selected select VBN cord-010092-uftc8inx 9522 17 , , , cord-010092-uftc8inx 9522 18 at at IN cord-010092-uftc8inx 9522 19 a a DT cord-010092-uftc8inx 9522 20 frequency frequency NN cord-010092-uftc8inx 9522 21 of of IN cord-010092-uftc8inx 9522 22 0.0049 0.0049 CD cord-010092-uftc8inx 9522 23 % % NN cord-010092-uftc8inx 9522 24 . . . cord-010092-uftc8inx 9523 1 Among among IN cord-010092-uftc8inx 9523 2 these these DT cord-010092-uftc8inx 9523 3 four four CD cord-010092-uftc8inx 9523 4 samples sample NNS cord-010092-uftc8inx 9523 5 available available JJ cord-010092-uftc8inx 9523 6 for for IN cord-010092-uftc8inx 9523 7 sequencing sequence VBG cord-010092-uftc8inx 9523 8 JK JK NNP cord-010092-uftc8inx 9523 9 gene gene NN cord-010092-uftc8inx 9523 10 , , , cord-010092-uftc8inx 9523 11 a a DT cord-010092-uftc8inx 9523 12 total total NN cord-010092-uftc8inx 9523 13 of of IN cord-010092-uftc8inx 9523 14 two two CD cord-010092-uftc8inx 9523 15 genotypes genotype NNS cord-010092-uftc8inx 9523 16 were be VBD cord-010092-uftc8inx 9523 17 discovered discover VBN cord-010092-uftc8inx 9523 18 : : : cord-010092-uftc8inx 9523 19 heterozygote heterozygote NN cord-010092-uftc8inx 9523 20 of of IN cord-010092-uftc8inx 9523 21 IVS5 IVS5 NNP cord-010092-uftc8inx 9523 22 - - HYPH cord-010092-uftc8inx 9523 23 1 1 CD cord-010092-uftc8inx 9523 24 G g NN cord-010092-uftc8inx 9524 1 > > XX cord-010092-uftc8inx 9525 1 A a DT cord-010092-uftc8inx 9525 2 combining combining NN cord-010092-uftc8inx 9525 3 with with IN cord-010092-uftc8inx 9525 4 heterozygote heterozygote NN cord-010092-uftc8inx 9525 5 of of IN cord-010092-uftc8inx 9525 6 359 359 CD cord-010092-uftc8inx 9525 7 G g NN cord-010092-uftc8inx 9526 1 > > XX cord-010092-uftc8inx 9527 1 A a DT cord-010092-uftc8inx 9527 2 ( ( -LRB- cord-010092-uftc8inx 9527 3 Gly120Glu gly120glu NN cord-010092-uftc8inx 9527 4 ) ) -RRB- cord-010092-uftc8inx 9527 5 and and CC cord-010092-uftc8inx 9527 6 heterozygote heterozygote NN cord-010092-uftc8inx 9527 7 of of IN cord-010092-uftc8inx 9527 8 896 896 CD cord-010092-uftc8inx 9527 9 G g NN cord-010092-uftc8inx 9528 1 > > XX cord-010092-uftc8inx 9529 1 A a DT cord-010092-uftc8inx 9529 2 ( ( -LRB- cord-010092-uftc8inx 9529 3 Gly299Glu gly299glu JJ cord-010092-uftc8inx 9529 4 ) ) -RRB- cord-010092-uftc8inx 9529 5 combining combine VBG cord-010092-uftc8inx 9529 6 with with IN cord-010092-uftc8inx 9529 7 heterozygote heterozygote NN cord-010092-uftc8inx 9529 8 of of IN cord-010092-uftc8inx 9529 9 956C 956c CD cord-010092-uftc8inx 9530 1 > > XX cord-010092-uftc8inx 9531 1 T(Thr319Met T(Thr319Met NNP cord-010092-uftc8inx 9531 2 ) ) -RRB- cord-010092-uftc8inx 9531 3 . . . cord-010092-uftc8inx 9532 1 Summary Summary NNP cord-010092-uftc8inx 9532 2 / / SYM cord-010092-uftc8inx 9532 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 9532 4 : : : cord-010092-uftc8inx 9533 1 The the DT cord-010092-uftc8inx 9533 2 frequency frequency NN cord-010092-uftc8inx 9533 3 of of IN cord-010092-uftc8inx 9533 4 Jk(a Jk(a NNP cord-010092-uftc8inx 9533 5 - - HYPH cord-010092-uftc8inx 9533 6 b- b- NNP cord-010092-uftc8inx 9533 7 ) ) -RRB- cord-010092-uftc8inx 9533 8 phenotype phenotype NN cord-010092-uftc8inx 9533 9 in in IN cord-010092-uftc8inx 9533 10 blood blood NN cord-010092-uftc8inx 9533 11 donors donor NNS cord-010092-uftc8inx 9533 12 in in IN cord-010092-uftc8inx 9533 13 Harbin Harbin NNP cord-010092-uftc8inx 9533 14 area area NN cord-010092-uftc8inx 9533 15 was be VBD cord-010092-uftc8inx 9533 16 lower low JJR cord-010092-uftc8inx 9533 17 than than IN cord-010092-uftc8inx 9533 18 the the DT cord-010092-uftc8inx 9533 19 reported report VBN cord-010092-uftc8inx 9533 20 data datum NNS cord-010092-uftc8inx 9533 21 from from IN cord-010092-uftc8inx 9533 22 the the DT cord-010092-uftc8inx 9533 23 populations population NNS cord-010092-uftc8inx 9533 24 in in IN cord-010092-uftc8inx 9533 25 other other JJ cord-010092-uftc8inx 9533 26 areas area NNS cord-010092-uftc8inx 9533 27 of of IN cord-010092-uftc8inx 9533 28 China China NNP cord-010092-uftc8inx 9533 29 and and CC cord-010092-uftc8inx 9533 30 in in IN cord-010092-uftc8inx 9533 31 Finland Finland NNP cord-010092-uftc8inx 9533 32 , , , cord-010092-uftc8inx 9533 33 but but CC cord-010092-uftc8inx 9533 34 higher high JJR cord-010092-uftc8inx 9533 35 than than IN cord-010092-uftc8inx 9533 36 that that DT cord-010092-uftc8inx 9533 37 in in IN cord-010092-uftc8inx 9533 38 Japan Japan NNP cord-010092-uftc8inx 9533 39 . . . cord-010092-uftc8inx 9534 1 IVS5 IVS5 NNP cord-010092-uftc8inx 9534 2 - - HYPH cord-010092-uftc8inx 9534 3 1 1 CD cord-010092-uftc8inx 9534 4 G g NN cord-010092-uftc8inx 9535 1 > > XX cord-010092-uftc8inx 9536 1 A a LS cord-010092-uftc8inx 9536 2 , , , cord-010092-uftc8inx 9536 3 896 896 CD cord-010092-uftc8inx 9536 4 G g NN cord-010092-uftc8inx 9537 1 > > XX cord-010092-uftc8inx 9538 1 A a NN cord-010092-uftc8inx 9538 2 and and CC cord-010092-uftc8inx 9538 3 956C 956c XX cord-010092-uftc8inx 9539 1 > > XX cord-010092-uftc8inx 9540 1 T T NNP cord-010092-uftc8inx 9540 2 were be VBD cord-010092-uftc8inx 9540 3 common common JJ cord-010092-uftc8inx 9540 4 mutations mutation NNS cord-010092-uftc8inx 9540 5 in in IN cord-010092-uftc8inx 9540 6 the the DT cord-010092-uftc8inx 9540 7 before before JJ cord-010092-uftc8inx 9540 8 reports report NNS cord-010092-uftc8inx 9540 9 , , , cord-010092-uftc8inx 9540 10 while while IN cord-010092-uftc8inx 9540 11 359 359 CD cord-010092-uftc8inx 9540 12 G g NN cord-010092-uftc8inx 9540 13 > > XX cord-010092-uftc8inx 9541 1 A a DT cord-010092-uftc8inx 9541 2 was be VBD cord-010092-uftc8inx 9541 3 reported report VBN cord-010092-uftc8inx 9541 4 first first JJ cord-010092-uftc8inx 9541 5 time time NN cord-010092-uftc8inx 9541 6 . . . cord-010092-uftc8inx 9542 1 In in IN cord-010092-uftc8inx 9542 2 addition addition NN cord-010092-uftc8inx 9542 3 , , , cord-010092-uftc8inx 9542 4 it -PRON- PRP cord-010092-uftc8inx 9542 5 is be VBZ cord-010092-uftc8inx 9542 6 an an DT cord-010092-uftc8inx 9542 7 effective effective JJ cord-010092-uftc8inx 9542 8 measure measure NN cord-010092-uftc8inx 9542 9 which which WDT cord-010092-uftc8inx 9542 10 establish establish VBP cord-010092-uftc8inx 9542 11 the the DT cord-010092-uftc8inx 9542 12 Jk(a Jk(a NNP cord-010092-uftc8inx 9542 13 - - HYPH cord-010092-uftc8inx 9542 14 b- b- NNP cord-010092-uftc8inx 9542 15 ) ) -RRB- cord-010092-uftc8inx 9543 1 phenotype phenotype NN cord-010092-uftc8inx 9543 2 donors donor NNS cord-010092-uftc8inx 9543 3 in in IN cord-010092-uftc8inx 9543 4 this this DT cord-010092-uftc8inx 9543 5 region region NN cord-010092-uftc8inx 9543 6 , , , cord-010092-uftc8inx 9544 1 to to TO cord-010092-uftc8inx 9544 2 solve solve VB cord-010092-uftc8inx 9544 3 the the DT cord-010092-uftc8inx 9544 4 blood blood NN cord-010092-uftc8inx 9544 5 transfusion transfusion NN cord-010092-uftc8inx 9544 6 problem problem NN cord-010092-uftc8inx 9544 7 in in IN cord-010092-uftc8inx 9544 8 patients patient NNS cord-010092-uftc8inx 9544 9 with with IN cord-010092-uftc8inx 9544 10 anti anti JJ cord-010092-uftc8inx 9544 11 - - JJ cord-010092-uftc8inx 9544 12 JK3 JK3 NNP cord-010092-uftc8inx 9544 13 . . . cord-010092-uftc8inx 9545 1 Background background NN cord-010092-uftc8inx 9545 2 : : : cord-010092-uftc8inx 9546 1 Blood blood NN cord-010092-uftc8inx 9546 2 types type NNS cord-010092-uftc8inx 9546 3 , , , cord-010092-uftc8inx 9546 4 indicating indicate VBG cord-010092-uftc8inx 9546 5 the the DT cord-010092-uftc8inx 9546 6 type type NN cord-010092-uftc8inx 9546 7 of of IN cord-010092-uftc8inx 9546 8 blood blood NN cord-010092-uftc8inx 9546 9 group group NN cord-010092-uftc8inx 9546 10 antigen antigen NN cord-010092-uftc8inx 9546 11 expressed express VBD cord-010092-uftc8inx 9546 12 in in IN cord-010092-uftc8inx 9546 13 the the DT cord-010092-uftc8inx 9546 14 red red JJ cord-010092-uftc8inx 9546 15 blood blood NN cord-010092-uftc8inx 9546 16 cells cell NNS cord-010092-uftc8inx 9546 17 , , , cord-010092-uftc8inx 9546 18 is be VBZ cord-010092-uftc8inx 9546 19 determined determine VBN cord-010092-uftc8inx 9546 20 by by IN cord-010092-uftc8inx 9546 21 the the DT cord-010092-uftc8inx 9546 22 type type NN cord-010092-uftc8inx 9546 23 of of IN cord-010092-uftc8inx 9546 24 allele allele NN cord-010092-uftc8inx 9546 25 at at IN cord-010092-uftc8inx 9546 26 the the DT cord-010092-uftc8inx 9546 27 blood blood NN cord-010092-uftc8inx 9546 28 group group NN cord-010092-uftc8inx 9546 29 gene gene NN cord-010092-uftc8inx 9546 30 locus locus NN cord-010092-uftc8inx 9546 31 . . . cord-010092-uftc8inx 9547 1 Therefore therefore RB cord-010092-uftc8inx 9547 2 , , , cord-010092-uftc8inx 9547 3 when when WRB cord-010092-uftc8inx 9547 4 allele allele NN cord-010092-uftc8inx 9547 5 frequency frequency NN cord-010092-uftc8inx 9547 6 of of IN cord-010092-uftc8inx 9547 7 each each DT cord-010092-uftc8inx 9547 8 blood blood NN cord-010092-uftc8inx 9547 9 group group NN cord-010092-uftc8inx 9547 10 gene gene NN cord-010092-uftc8inx 9547 11 is be VBZ cord-010092-uftc8inx 9547 12 determined determine VBN cord-010092-uftc8inx 9547 13 , , , cord-010092-uftc8inx 9547 14 it -PRON- PRP cord-010092-uftc8inx 9547 15 is be VBZ cord-010092-uftc8inx 9547 16 possible possible JJ cord-010092-uftc8inx 9547 17 to to TO cord-010092-uftc8inx 9547 18 predict predict VB cord-010092-uftc8inx 9547 19 the the DT cord-010092-uftc8inx 9547 20 frequency frequency NN cord-010092-uftc8inx 9547 21 of of IN cord-010092-uftc8inx 9547 22 a a DT cord-010092-uftc8inx 9547 23 specific specific JJ cord-010092-uftc8inx 9547 24 blood blood NN cord-010092-uftc8inx 9547 25 type type NN cord-010092-uftc8inx 9547 26 donor donor NN cord-010092-uftc8inx 9547 27 with with IN cord-010092-uftc8inx 9547 28 a a DT cord-010092-uftc8inx 9547 29 homozygous homozygous JJ cord-010092-uftc8inx 9547 30 allele allele NN cord-010092-uftc8inx 9547 31 . . . cord-010092-uftc8inx 9548 1 It -PRON- PRP cord-010092-uftc8inx 9548 2 is be VBZ cord-010092-uftc8inx 9548 3 also also RB cord-010092-uftc8inx 9548 4 possible possible JJ cord-010092-uftc8inx 9548 5 to to TO cord-010092-uftc8inx 9548 6 estimate estimate VB cord-010092-uftc8inx 9548 7 the the DT cord-010092-uftc8inx 9548 8 proportion proportion NN cord-010092-uftc8inx 9548 9 of of IN cord-010092-uftc8inx 9548 10 donors donor NNS cord-010092-uftc8inx 9548 11 within within IN cord-010092-uftc8inx 9548 12 a a DT cord-010092-uftc8inx 9548 13 particular particular JJ cord-010092-uftc8inx 9548 14 blood blood NN cord-010092-uftc8inx 9548 15 type type NN cord-010092-uftc8inx 9548 16 through through IN cord-010092-uftc8inx 9548 17 combination combination NN cord-010092-uftc8inx 9548 18 of of IN cord-010092-uftc8inx 9548 19 specific specific JJ cord-010092-uftc8inx 9548 20 alleles allele NNS cord-010092-uftc8inx 9548 21 . . . cord-010092-uftc8inx 9549 1 And and CC cord-010092-uftc8inx 9549 2 because because IN cord-010092-uftc8inx 9549 3 the the DT cord-010092-uftc8inx 9549 4 ratio ratio NN cord-010092-uftc8inx 9549 5 of of IN cord-010092-uftc8inx 9549 6 blood blood NN cord-010092-uftc8inx 9549 7 group group NN cord-010092-uftc8inx 9549 8 allele allele NN cord-010092-uftc8inx 9549 9 differs differ VBZ cord-010092-uftc8inx 9549 10 between between IN cord-010092-uftc8inx 9549 11 ethnicity ethnicity NN cord-010092-uftc8inx 9549 12 and and CC cord-010092-uftc8inx 9549 13 race race NN cord-010092-uftc8inx 9549 14 , , , cord-010092-uftc8inx 9549 15 this this DT cord-010092-uftc8inx 9549 16 can can MD cord-010092-uftc8inx 9549 17 be be VB cord-010092-uftc8inx 9549 18 used use VBN cord-010092-uftc8inx 9549 19 as as IN cord-010092-uftc8inx 9549 20 basic basic JJ cord-010092-uftc8inx 9549 21 data datum NNS cord-010092-uftc8inx 9549 22 for for IN cord-010092-uftc8inx 9549 23 population population NN cord-010092-uftc8inx 9549 24 genetics genetic NNS cord-010092-uftc8inx 9549 25 and and CC cord-010092-uftc8inx 9549 26 anthropology anthropology NN cord-010092-uftc8inx 9549 27 . . . cord-010092-uftc8inx 9550 1 Therefore therefore RB cord-010092-uftc8inx 9550 2 , , , cord-010092-uftc8inx 9550 3 we -PRON- PRP cord-010092-uftc8inx 9550 4 present present VBP cord-010092-uftc8inx 9550 5 a a DT cord-010092-uftc8inx 9550 6 study study NN cord-010092-uftc8inx 9550 7 that that WDT cord-010092-uftc8inx 9550 8 examined examine VBD cord-010092-uftc8inx 9550 9 the the DT cord-010092-uftc8inx 9550 10 allele allele NN cord-010092-uftc8inx 9550 11 frequencies frequency NNS cord-010092-uftc8inx 9550 12 of of IN cord-010092-uftc8inx 9550 13 10 10 CD cord-010092-uftc8inx 9550 14 blood blood NN cord-010092-uftc8inx 9550 15 group group NN cord-010092-uftc8inx 9550 16 systems system NNS cord-010092-uftc8inx 9550 17 in in IN cord-010092-uftc8inx 9550 18 the the DT cord-010092-uftc8inx 9550 19 Korean korean JJ cord-010092-uftc8inx 9550 20 population population NN cord-010092-uftc8inx 9550 21 through through IN cord-010092-uftc8inx 9550 22 blood blood NN cord-010092-uftc8inx 9550 23 group group NN cord-010092-uftc8inx 9550 24 genotyping genotyping NN cord-010092-uftc8inx 9550 25 . . . cord-010092-uftc8inx 9551 1 Aims aim VBZ cord-010092-uftc8inx 9551 2 : : : cord-010092-uftc8inx 9552 1 The the DT cord-010092-uftc8inx 9552 2 purpose purpose NN cord-010092-uftc8inx 9552 3 of of IN cord-010092-uftc8inx 9552 4 this this DT cord-010092-uftc8inx 9552 5 study study NN cord-010092-uftc8inx 9552 6 is be VBZ cord-010092-uftc8inx 9552 7 to to TO cord-010092-uftc8inx 9552 8 determine determine VB cord-010092-uftc8inx 9552 9 the the DT cord-010092-uftc8inx 9552 10 frequencies frequency NNS cord-010092-uftc8inx 9552 11 of of IN cord-010092-uftc8inx 9552 12 blood blood NN cord-010092-uftc8inx 9552 13 group group NN cord-010092-uftc8inx 9552 14 alleles allele NNS cord-010092-uftc8inx 9552 15 in in IN cord-010092-uftc8inx 9552 16 the the DT cord-010092-uftc8inx 9552 17 Korean korean JJ cord-010092-uftc8inx 9552 18 population population NN cord-010092-uftc8inx 9552 19 , , , cord-010092-uftc8inx 9552 20 to to TO cord-010092-uftc8inx 9552 21 predict predict VB cord-010092-uftc8inx 9552 22 the the DT cord-010092-uftc8inx 9552 23 proportion proportion NN cord-010092-uftc8inx 9552 24 of of IN cord-010092-uftc8inx 9552 25 homozygous homozygous JJ cord-010092-uftc8inx 9552 26 donors donor NNS cord-010092-uftc8inx 9552 27 , , , cord-010092-uftc8inx 9552 28 and and CC cord-010092-uftc8inx 9552 29 to to TO cord-010092-uftc8inx 9552 30 obtain obtain VB cord-010092-uftc8inx 9552 31 the the DT cord-010092-uftc8inx 9552 32 basic basic JJ cord-010092-uftc8inx 9552 33 data datum NNS cord-010092-uftc8inx 9552 34 of of IN cord-010092-uftc8inx 9552 35 population population NN cord-010092-uftc8inx 9552 36 genetics genetics NN cord-010092-uftc8inx 9552 37 . . . cord-010092-uftc8inx 9553 1 Methods method NNS cord-010092-uftc8inx 9553 2 : : : cord-010092-uftc8inx 9553 3 5,213 5,213 CD cord-010092-uftc8inx 9553 4 blood blood NN cord-010092-uftc8inx 9553 5 donors donor NNS cord-010092-uftc8inx 9553 6 from from IN cord-010092-uftc8inx 9553 7 age age NN cord-010092-uftc8inx 9553 8 19 19 CD cord-010092-uftc8inx 9553 9 to to TO cord-010092-uftc8inx 9553 10 54 54 CD cord-010092-uftc8inx 9553 11 were be VBD cord-010092-uftc8inx 9553 12 recruited recruit VBN cord-010092-uftc8inx 9553 13 at at IN cord-010092-uftc8inx 9553 14 Korean Korean NNP cord-010092-uftc8inx 9553 15 Red Red NNP cord-010092-uftc8inx 9553 16 Cross Cross NNP cord-010092-uftc8inx 9553 17 blood blood NN cord-010092-uftc8inx 9553 18 centers center NNS cord-010092-uftc8inx 9553 19 located locate VBN cord-010092-uftc8inx 9553 20 nationwide nationwide RB cord-010092-uftc8inx 9553 21 . . . cord-010092-uftc8inx 9554 1 Acquired acquire VBN cord-010092-uftc8inx 9554 2 samples sample NNS cord-010092-uftc8inx 9554 3 were be VBD cord-010092-uftc8inx 9554 4 examined examine VBN cord-010092-uftc8inx 9554 5 by by IN cord-010092-uftc8inx 9554 6 blood blood NN cord-010092-uftc8inx 9554 7 group group NN cord-010092-uftc8inx 9554 8 genotyping genotyping NN cord-010092-uftc8inx 9554 9 methods method NNS cord-010092-uftc8inx 9554 10 using use VBG cord-010092-uftc8inx 9554 11 the the DT cord-010092-uftc8inx 9554 12 RBC RBC NNP cord-010092-uftc8inx 9554 13 genotyping genotyping NN cord-010092-uftc8inx 9554 14 system system NN cord-010092-uftc8inx 9554 15 ID ID NNP cord-010092-uftc8inx 9554 16 CORE core NN cord-010092-uftc8inx 9554 17 XT XT NNP cord-010092-uftc8inx 9554 18 ( ( -LRB- cord-010092-uftc8inx 9554 19 Progenika Progenika NNP cord-010092-uftc8inx 9554 20 Biopharma Biopharma NNP cord-010092-uftc8inx 9554 21 ) ) -RRB- cord-010092-uftc8inx 9554 22 . . . cord-010092-uftc8inx 9555 1 For for IN cord-010092-uftc8inx 9555 2 each each DT cord-010092-uftc8inx 9555 3 donor donor NN cord-010092-uftc8inx 9555 4 , , , cord-010092-uftc8inx 9555 5 genotypes genotype NNS cord-010092-uftc8inx 9555 6 of of IN cord-010092-uftc8inx 9555 7 10 10 CD cord-010092-uftc8inx 9555 8 blood blood NN cord-010092-uftc8inx 9555 9 group group NN cord-010092-uftc8inx 9555 10 systems system NNS cord-010092-uftc8inx 9555 11 , , , cord-010092-uftc8inx 9555 12 excluding exclude VBG cord-010092-uftc8inx 9555 13 ABO ABO NNP cord-010092-uftc8inx 9555 14 and and CC cord-010092-uftc8inx 9555 15 RhD RhD NNP cord-010092-uftc8inx 9555 16 , , , cord-010092-uftc8inx 9555 17 were be VBD cord-010092-uftc8inx 9555 18 identified identify VBN cord-010092-uftc8inx 9555 19 . . . cord-010092-uftc8inx 9556 1 Calculation calculation NN cord-010092-uftc8inx 9556 2 of of IN cord-010092-uftc8inx 9556 3 the the DT cord-010092-uftc8inx 9556 4 frequencies frequency NNS cord-010092-uftc8inx 9556 5 of of IN cord-010092-uftc8inx 9556 6 blood blood NN cord-010092-uftc8inx 9556 7 group group NN cord-010092-uftc8inx 9556 8 alleles allele NNS cord-010092-uftc8inx 9556 9 in in IN cord-010092-uftc8inx 9556 10 the the DT cord-010092-uftc8inx 9556 11 Korean korean JJ cord-010092-uftc8inx 9556 12 population population NN cord-010092-uftc8inx 9556 13 was be VBD cord-010092-uftc8inx 9556 14 done do VBN cord-010092-uftc8inx 9556 15 . . . cord-010092-uftc8inx 9557 1 Results result NNS cord-010092-uftc8inx 9557 2 : : : cord-010092-uftc8inx 9558 1 We -PRON- PRP cord-010092-uftc8inx 9558 2 conducted conduct VBD cord-010092-uftc8inx 9558 3 molecular molecular JJ cord-010092-uftc8inx 9558 4 genotyping genotyping NN cord-010092-uftc8inx 9558 5 of of IN cord-010092-uftc8inx 9558 6 the the DT cord-010092-uftc8inx 9558 7 RhCE rhce NN cord-010092-uftc8inx 9558 8 , , , cord-010092-uftc8inx 9558 9 Kell Kell NNP cord-010092-uftc8inx 9558 10 , , , cord-010092-uftc8inx 9558 11 Kidd Kidd NNP cord-010092-uftc8inx 9558 12 , , , cord-010092-uftc8inx 9558 13 Duffy Duffy NNP cord-010092-uftc8inx 9558 14 , , , cord-010092-uftc8inx 9558 15 MNSs mns NNS cord-010092-uftc8inx 9558 16 , , , cord-010092-uftc8inx 9558 17 Diego Diego NNP cord-010092-uftc8inx 9558 18 , , , cord-010092-uftc8inx 9558 19 Dombrock Dombrock NNP cord-010092-uftc8inx 9558 20 , , , cord-010092-uftc8inx 9558 21 Colton Colton NNP cord-010092-uftc8inx 9558 22 , , , cord-010092-uftc8inx 9558 23 Cartwright Cartwright NNP cord-010092-uftc8inx 9558 24 , , , cord-010092-uftc8inx 9558 25 and and CC cord-010092-uftc8inx 9558 26 Lutheran Lutheran NNP cord-010092-uftc8inx 9558 27 blood blood NN cord-010092-uftc8inx 9558 28 group group NN cord-010092-uftc8inx 9558 29 systems system NNS cord-010092-uftc8inx 9558 30 . . . cord-010092-uftc8inx 9559 1 The the DT cord-010092-uftc8inx 9559 2 allele allele NN cord-010092-uftc8inx 9559 3 frequencies frequency NNS cord-010092-uftc8inx 9559 4 of of IN cord-010092-uftc8inx 9559 5 these these DT cord-010092-uftc8inx 9559 6 blood blood NN cord-010092-uftc8inx 9559 7 group group NN cord-010092-uftc8inx 9559 8 systems system NNS cord-010092-uftc8inx 9559 9 in in IN cord-010092-uftc8inx 9559 10 the the DT cord-010092-uftc8inx 9559 11 Korean korean JJ cord-010092-uftc8inx 9559 12 population population NN cord-010092-uftc8inx 9559 13 were be VBD cord-010092-uftc8inx 9559 14 estimated estimate VBN cord-010092-uftc8inx 9559 15 as as IN cord-010092-uftc8inx 9559 16 follows follow VBZ cord-010092-uftc8inx 9559 17 . . . cord-010092-uftc8inx 9560 1 -RHCE*CE -RHCE*CE . cord-010092-uftc8inx 9561 1 0.3 0.3 CD cord-010092-uftc8inx 9561 2 % % NN cord-010092-uftc8inx 9561 3 , , , cord-010092-uftc8inx 9561 4 RHCE*Ce rhce*ce NN cord-010092-uftc8inx 9561 5 65.0 65.0 CD cord-010092-uftc8inx 9561 6 % % NN cord-010092-uftc8inx 9561 7 , , , cord-010092-uftc8inx 9561 8 RHCE*cE rhce*ce JJ cord-010092-uftc8inx 9561 9 28.8 28.8 CD cord-010092-uftc8inx 9561 10 % % NN cord-010092-uftc8inx 9561 11 , , , cord-010092-uftc8inx 9561 12 RHCE*ce rhce*ce IN cord-010092-uftc8inx 9561 13 5.9 5.9 CD cord-010092-uftc8inx 9561 14 % % NN cord-010092-uftc8inx 9561 15 -KEL*k_KPB_JSB -kel*k_kpb_jsb NN cord-010092-uftc8inx 9561 16 allele allele NN cord-010092-uftc8inx 9561 17 100 100 CD cord-010092-uftc8inx 9561 18 % % NN cord-010092-uftc8inx 9561 19 -JK*A -JK*A HYPH cord-010092-uftc8inx 9561 20 allele allele NN cord-010092-uftc8inx 9561 21 49.1 49.1 CD cord-010092-uftc8inx 9561 22 % % NN cord-010092-uftc8inx 9561 23 , , , cord-010092-uftc8inx 9561 24 JK*B jk*b DT cord-010092-uftc8inx 9561 25 allele allele NN cord-010092-uftc8inx 9561 26 50.8 50.8 CD cord-010092-uftc8inx 9561 27 % % NN cord-010092-uftc8inx 9561 28 , , , cord-010092-uftc8inx 9561 29 JK*B_null JK*B_null NNP cord-010092-uftc8inx 9561 30 allele allele NN cord-010092-uftc8inx 9561 31 0.1 0.1 CD cord-010092-uftc8inx 9561 32 % % NN cord-010092-uftc8inx 9562 1 -FY*A -FY*A : cord-010092-uftc8inx 9562 2 allele allele NNP cord-010092-uftc8inx 9562 3 92.8 92.8 CD cord-010092-uftc8inx 9562 4 % % NN cord-010092-uftc8inx 9562 5 , , , cord-010092-uftc8inx 9562 6 FY*B FY*B NNP cord-010092-uftc8inx 9562 7 allele allele NN cord-010092-uftc8inx 9562 8 7.2 7.2 CD cord-010092-uftc8inx 9562 9 % % NN cord-010092-uftc8inx 9563 1 -GYPA*M -GYPA*M NNP cord-010092-uftc8inx 9564 1 allele allele NN cord-010092-uftc8inx 9564 2 51.1 51.1 CD cord-010092-uftc8inx 9564 3 % % NN cord-010092-uftc8inx 9564 4 , , , cord-010092-uftc8inx 9564 5 GYPA*N GYPA*N NNP cord-010092-uftc8inx 9564 6 allele allele NN cord-010092-uftc8inx 9564 7 48.9 48.9 CD cord-010092-uftc8inx 9564 8 % % NN cord-010092-uftc8inx 9564 9 -GYPB*S -gypb*s NN cord-010092-uftc8inx 9565 1 allele allele NNP cord-010092-uftc8inx 9566 1 5.1 5.1 CD cord-010092-uftc8inx 9566 2 % % NN cord-010092-uftc8inx 9566 3 , , , cord-010092-uftc8inx 9566 4 GYPB*s gypb*s NN cord-010092-uftc8inx 9566 5 allele allele NN cord-010092-uftc8inx 9566 6 94.8 94.8 CD cord-010092-uftc8inx 9566 7 % % NN cord-010092-uftc8inx 9566 8 , , , cord-010092-uftc8inx 9566 9 GYPB*Mur GYPB*Mur NNP cord-010092-uftc8inx 9566 10 allele allele NN cord-010092-uftc8inx 9566 11 0.1 0.1 CD cord-010092-uftc8inx 9566 12 % % NN cord-010092-uftc8inx 9567 1 -DI*A -DI*A : cord-010092-uftc8inx 9567 2 allele allele NN cord-010092-uftc8inx 9567 3 4.7 4.7 CD cord-010092-uftc8inx 9567 4 % % NN cord-010092-uftc8inx 9567 5 , , , cord-010092-uftc8inx 9567 6 DI*B DI*B NNP cord-010092-uftc8inx 9567 7 allele allele NN cord-010092-uftc8inx 9567 8 95.3 95.3 CD cord-010092-uftc8inx 9567 9 % % NN cord-010092-uftc8inx 9568 1 -DO*A -DO*A . cord-010092-uftc8inx 9569 1 allele allele NN cord-010092-uftc8inx 9569 2 10.1 10.1 CD cord-010092-uftc8inx 9569 3 % % NN cord-010092-uftc8inx 9569 4 , , , cord-010092-uftc8inx 9570 1 DO*B DO*B NNP cord-010092-uftc8inx 9570 2 allele allele NN cord-010092-uftc8inx 9570 3 89.9 89.9 CD cord-010092-uftc8inx 9570 4 % % NN cord-010092-uftc8inx 9570 5 -CO*A -CO*A . cord-010092-uftc8inx 9571 1 allele allele NN cord-010092-uftc8inx 9571 2 100 100 CD cord-010092-uftc8inx 9571 3 % % NN cord-010092-uftc8inx 9571 4 -YT*A -YT*A . cord-010092-uftc8inx 9571 5 allele allele NN cord-010092-uftc8inx 9572 1 100 100 CD cord-010092-uftc8inx 9572 2 % % NN cord-010092-uftc8inx 9572 3 -LU*B -LU*B HYPH cord-010092-uftc8inx 9572 4 allele allele NN cord-010092-uftc8inx 9573 1 100 100 CD cord-010092-uftc8inx 9573 2 % % NN cord-010092-uftc8inx 9573 3 Summary Summary NNP cord-010092-uftc8inx 9573 4 / / SYM cord-010092-uftc8inx 9573 5 Conclusions Conclusions NNPS cord-010092-uftc8inx 9573 6 : : : cord-010092-uftc8inx 9574 1 The the DT cord-010092-uftc8inx 9574 2 significance significance NN cord-010092-uftc8inx 9574 3 of of IN cord-010092-uftc8inx 9574 4 this this DT cord-010092-uftc8inx 9574 5 study study NN cord-010092-uftc8inx 9574 6 is be VBZ cord-010092-uftc8inx 9574 7 accumulation accumulation NN cord-010092-uftc8inx 9574 8 of of IN cord-010092-uftc8inx 9574 9 data datum NNS cord-010092-uftc8inx 9574 10 on on IN cord-010092-uftc8inx 9574 11 the the DT cord-010092-uftc8inx 9574 12 allele allele NN cord-010092-uftc8inx 9574 13 frequencies frequency NNS cord-010092-uftc8inx 9574 14 of of IN cord-010092-uftc8inx 9574 15 blood blood NN cord-010092-uftc8inx 9574 16 group group NN cord-010092-uftc8inx 9574 17 genes gene NNS cord-010092-uftc8inx 9574 18 through through IN cord-010092-uftc8inx 9574 19 highly highly RB cord-010092-uftc8inx 9574 20 accurate accurate JJ cord-010092-uftc8inx 9574 21 genotyping genotyping NN cord-010092-uftc8inx 9574 22 method method NN cord-010092-uftc8inx 9574 23 in in IN cord-010092-uftc8inx 9574 24 the the DT cord-010092-uftc8inx 9574 25 East East NNP cord-010092-uftc8inx 9574 26 Asia Asia NNP cord-010092-uftc8inx 9574 27 region region NN cord-010092-uftc8inx 9574 28 . . . cord-010092-uftc8inx 9575 1 This this DT cord-010092-uftc8inx 9575 2 enables enable VBZ cord-010092-uftc8inx 9575 3 the the DT cord-010092-uftc8inx 9575 4 prediction prediction NN cord-010092-uftc8inx 9575 5 of of IN cord-010092-uftc8inx 9575 6 the the DT cord-010092-uftc8inx 9575 7 proportion proportion NN cord-010092-uftc8inx 9575 8 of of IN cord-010092-uftc8inx 9575 9 donors donor NNS cord-010092-uftc8inx 9575 10 with with IN cord-010092-uftc8inx 9575 11 a a DT cord-010092-uftc8inx 9575 12 combination combination NN cord-010092-uftc8inx 9575 13 of of IN cord-010092-uftc8inx 9575 14 specific specific JJ cord-010092-uftc8inx 9575 15 blood blood NN cord-010092-uftc8inx 9575 16 group group NN cord-010092-uftc8inx 9575 17 alleles allele NNS cord-010092-uftc8inx 9575 18 in in IN cord-010092-uftc8inx 9575 19 the the DT cord-010092-uftc8inx 9575 20 Korean korean JJ cord-010092-uftc8inx 9575 21 population population NN cord-010092-uftc8inx 9575 22 , , , cord-010092-uftc8inx 9575 23 which which WDT cord-010092-uftc8inx 9575 24 accounts account VBZ cord-010092-uftc8inx 9575 25 for for IN cord-010092-uftc8inx 9575 26 a a DT cord-010092-uftc8inx 9575 27 decent decent JJ cord-010092-uftc8inx 9575 28 percentage percentage NN cord-010092-uftc8inx 9575 29 of of IN cord-010092-uftc8inx 9575 30 the the DT cord-010092-uftc8inx 9575 31 population population NN cord-010092-uftc8inx 9575 32 in in IN cord-010092-uftc8inx 9575 33 this this DT cord-010092-uftc8inx 9575 34 region region NN cord-010092-uftc8inx 9575 35 . . . cord-010092-uftc8inx 9576 1 Background background NN cord-010092-uftc8inx 9576 2 : : : cord-010092-uftc8inx 9577 1 In in IN cord-010092-uftc8inx 9577 2 donors donor NNS cord-010092-uftc8inx 9577 3 from from IN cord-010092-uftc8inx 9577 4 Arabian arabian JJ cord-010092-uftc8inx 9577 5 countries country NNS cord-010092-uftc8inx 9577 6 only only RB cord-010092-uftc8inx 9577 7 little little JJ cord-010092-uftc8inx 9577 8 is be VBZ cord-010092-uftc8inx 9577 9 known know VBN cord-010092-uftc8inx 9577 10 about about IN cord-010092-uftc8inx 9577 11 blood blood NN cord-010092-uftc8inx 9577 12 groups group NNS cord-010092-uftc8inx 9577 13 other other JJ cord-010092-uftc8inx 9577 14 than than IN cord-010092-uftc8inx 9577 15 ABO ABO NNP cord-010092-uftc8inx 9577 16 and and CC cord-010092-uftc8inx 9577 17 Rhesus Rhesus NNP cord-010092-uftc8inx 9577 18 . . . cord-010092-uftc8inx 9578 1 During during IN cord-010092-uftc8inx 9578 2 the the DT cord-010092-uftc8inx 9578 3 last last JJ cord-010092-uftc8inx 9578 4 years year NNS cord-010092-uftc8inx 9578 5 increased increase VBD cord-010092-uftc8inx 9578 6 migration migration NN cord-010092-uftc8inx 9578 7 to to IN cord-010092-uftc8inx 9578 8 Central Central NNP cord-010092-uftc8inx 9578 9 Europe Europe NNP cord-010092-uftc8inx 9578 10 has have VBZ cord-010092-uftc8inx 9578 11 put put VBN cord-010092-uftc8inx 9578 12 a a DT cord-010092-uftc8inx 9578 13 focus focus NN cord-010092-uftc8inx 9578 14 on on IN cord-010092-uftc8inx 9578 15 the the DT cord-010092-uftc8inx 9578 16 question question NN cord-010092-uftc8inx 9578 17 how how WRB cord-010092-uftc8inx 9578 18 to to TO cord-010092-uftc8inx 9578 19 guarantee guarantee VB cord-010092-uftc8inx 9578 20 blood blood NN cord-010092-uftc8inx 9578 21 supply supply NN cord-010092-uftc8inx 9578 22 for for IN cord-010092-uftc8inx 9578 23 patients patient NNS cord-010092-uftc8inx 9578 24 from from IN cord-010092-uftc8inx 9578 25 these these DT cord-010092-uftc8inx 9578 26 countries country NNS cord-010092-uftc8inx 9578 27 , , , cord-010092-uftc8inx 9578 28 particularly particularly RB cord-010092-uftc8inx 9578 29 because because IN cord-010092-uftc8inx 9578 30 hemoglobinopathies hemoglobinopathy NNS cord-010092-uftc8inx 9578 31 with with IN cord-010092-uftc8inx 9578 32 the the DT cord-010092-uftc8inx 9578 33 need need NN cord-010092-uftc8inx 9578 34 of of IN cord-010092-uftc8inx 9578 35 regular regular JJ cord-010092-uftc8inx 9578 36 blood blood NN cord-010092-uftc8inx 9578 37 support support NN cord-010092-uftc8inx 9578 38 are be VBP cord-010092-uftc8inx 9578 39 more more RBR cord-010092-uftc8inx 9578 40 frequent frequent JJ cord-010092-uftc8inx 9578 41 in in IN cord-010092-uftc8inx 9578 42 patients patient NNS cord-010092-uftc8inx 9578 43 from from IN cord-010092-uftc8inx 9578 44 that that DT cord-010092-uftc8inx 9578 45 region region NN cord-010092-uftc8inx 9578 46 . . . cord-010092-uftc8inx 9579 1 Aims aim VBZ cord-010092-uftc8inx 9579 2 : : : cord-010092-uftc8inx 9579 3 Blood blood NN cord-010092-uftc8inx 9579 4 group group NN cord-010092-uftc8inx 9579 5 allele allele NN cord-010092-uftc8inx 9579 6 frequencies frequency NNS cord-010092-uftc8inx 9579 7 should should MD cord-010092-uftc8inx 9579 8 be be VB cord-010092-uftc8inx 9579 9 determined determine VBN cord-010092-uftc8inx 9579 10 in in IN cord-010092-uftc8inx 9579 11 individuals individual NNS cord-010092-uftc8inx 9579 12 from from IN cord-010092-uftc8inx 9579 13 Syria Syria NNP cord-010092-uftc8inx 9579 14 , , , cord-010092-uftc8inx 9579 15 other other JJ cord-010092-uftc8inx 9579 16 Arabian arabian JJ cord-010092-uftc8inx 9579 17 countries country NNS cord-010092-uftc8inx 9579 18 , , , cord-010092-uftc8inx 9579 19 and and CC cord-010092-uftc8inx 9579 20 Iran Iran NNP cord-010092-uftc8inx 9579 21 by by IN cord-010092-uftc8inx 9579 22 molecular molecular JJ cord-010092-uftc8inx 9579 23 typing typing NN cord-010092-uftc8inx 9579 24 . . . cord-010092-uftc8inx 9580 1 Methods method NNS cord-010092-uftc8inx 9580 2 : : : cord-010092-uftc8inx 9581 1 As as IN cord-010092-uftc8inx 9581 2 most most JJS cord-010092-uftc8inx 9581 3 blood blood NN cord-010092-uftc8inx 9581 4 groups group NNS cord-010092-uftc8inx 9581 5 are be VBP cord-010092-uftc8inx 9581 6 defined define VBN cord-010092-uftc8inx 9581 7 by by IN cord-010092-uftc8inx 9581 8 single single JJ cord-010092-uftc8inx 9581 9 nucleotide nucleotide JJ cord-010092-uftc8inx 9581 10 polymorphisms polymorphism NNS cord-010092-uftc8inx 9581 11 ( ( -LRB- cord-010092-uftc8inx 9581 12 SNPs SNPs NNP cord-010092-uftc8inx 9581 13 ) ) -RRB- cord-010092-uftc8inx 9581 14 we -PRON- PRP cord-010092-uftc8inx 9581 15 introduced introduce VBD cord-010092-uftc8inx 9581 16 a a DT cord-010092-uftc8inx 9581 17 MALDI MALDI NNP cord-010092-uftc8inx 9581 18 - - HYPH cord-010092-uftc8inx 9581 19 TOF TOF NNP cord-010092-uftc8inx 9581 20 MS MS NNP cord-010092-uftc8inx 9581 21 assay assay NN cord-010092-uftc8inx 9581 22 to to TO cord-010092-uftc8inx 9581 23 detect detect VB cord-010092-uftc8inx 9581 24 alleles allele NNS cord-010092-uftc8inx 9581 25 encoding encode VBG cord-010092-uftc8inx 9581 26 16 16 CD cord-010092-uftc8inx 9581 27 blood blood NN cord-010092-uftc8inx 9581 28 groups group NNS cord-010092-uftc8inx 9581 29 including include VBG cord-010092-uftc8inx 9581 30 Kk Kk NNP cord-010092-uftc8inx 9581 31 , , , cord-010092-uftc8inx 9581 32 Fy Fy NNP cord-010092-uftc8inx 9581 33 ( ( -LRB- cord-010092-uftc8inx 9581 34 a a NN cord-010092-uftc8inx 9581 35 / / SYM cord-010092-uftc8inx 9581 36 b b NN cord-010092-uftc8inx 9581 37 ) ) -RRB- cord-010092-uftc8inx 9581 38 , , , cord-010092-uftc8inx 9581 39 Fy Fy NNP cord-010092-uftc8inx 9581 40 null null NN cord-010092-uftc8inx 9581 41 , , , cord-010092-uftc8inx 9581 42 C C NNP cord-010092-uftc8inx 9581 43 w w NNP cord-010092-uftc8inx 9581 44 , , , cord-010092-uftc8inx 9581 45 Jk(a Jk(a NNP cord-010092-uftc8inx 9581 46 / / SYM cord-010092-uftc8inx 9581 47 b b NNP cord-010092-uftc8inx 9581 48 ) ) -RRB- cord-010092-uftc8inx 9581 49 , , , cord-010092-uftc8inx 9581 50 Jo(a+/a- Jo(a+/a- NNP cord-010092-uftc8inx 9581 51 ) ) -RRB- cord-010092-uftc8inx 9581 52 , , , cord-010092-uftc8inx 9581 53 Lu(a Lu(a NNP cord-010092-uftc8inx 9581 54 / / SYM cord-010092-uftc8inx 9581 55 b b NNP cord-010092-uftc8inx 9581 56 ) ) -RRB- cord-010092-uftc8inx 9581 57 , , , cord-010092-uftc8inx 9581 58 Lu Lu NNP cord-010092-uftc8inx 9581 59 ( ( -LRB- cord-010092-uftc8inx 9581 60 8/14 8/14 CD cord-010092-uftc8inx 9581 61 ) ) -RRB- cord-010092-uftc8inx 9581 62 , , , cord-010092-uftc8inx 9581 63 Ss Ss NNP cord-010092-uftc8inx 9581 64 , , , cord-010092-uftc8inx 9581 65 Do do VBP cord-010092-uftc8inx 9581 66 ( ( -LRB- cord-010092-uftc8inx 9581 67 a a NN cord-010092-uftc8inx 9581 68 / / SYM cord-010092-uftc8inx 9581 69 b b NN cord-010092-uftc8inx 9581 70 ) ) -RRB- cord-010092-uftc8inx 9581 71 , , , cord-010092-uftc8inx 9581 72 Co(a Co(a NNP cord-010092-uftc8inx 9581 73 / / SYM cord-010092-uftc8inx 9581 74 b b NN cord-010092-uftc8inx 9581 75 ) ) -RRB- cord-010092-uftc8inx 9581 76 , , , cord-010092-uftc8inx 9581 77 In(a In(a NNP cord-010092-uftc8inx 9581 78 / / SYM cord-010092-uftc8inx 9581 79 b b NN cord-010092-uftc8inx 9581 80 ) ) -RRB- cord-010092-uftc8inx 9581 81 , , , cord-010092-uftc8inx 9581 82 Js(a Js(a NNP cord-010092-uftc8inx 9581 83 / / SYM cord-010092-uftc8inx 9581 84 b b NN cord-010092-uftc8inx 9581 85 ) ) -RRB- cord-010092-uftc8inx 9581 86 , , , cord-010092-uftc8inx 9581 87 Kp(a Kp(a NNP cord-010092-uftc8inx 9581 88 / / SYM cord-010092-uftc8inx 9581 89 b b NNP cord-010092-uftc8inx 9581 90 ) ) -RRB- cord-010092-uftc8inx 9581 91 , , . cord-010092-uftc8inx 9582 1 RHCE*c.697C RHCE*c.697C NNP cord-010092-uftc8inx 9582 2 > > SYM cord-010092-uftc8inx 9582 3 G G NNP cord-010092-uftc8inx 9582 4 , , , cord-010092-uftc8inx 9582 5 and and CC cord-010092-uftc8inx 9583 1 RHCE*c.733C RHCE*c.733C NNP cord-010092-uftc8inx 9583 2 > > SYM cord-010092-uftc8inx 9583 3 G. G. NNP cord-010092-uftc8inx 9583 4 Additional additional JJ cord-010092-uftc8inx 9583 5 blood blood NN cord-010092-uftc8inx 9583 6 groups group NNS cord-010092-uftc8inx 9583 7 and and CC cord-010092-uftc8inx 9583 8 polymorphisms polymorphism NNS cord-010092-uftc8inx 9583 9 like like IN cord-010092-uftc8inx 9583 10 Yt(a Yt(a NNP cord-010092-uftc8inx 9583 11 / / SYM cord-010092-uftc8inx 9583 12 b b NN cord-010092-uftc8inx 9583 13 ) ) -RRB- cord-010092-uftc8inx 9584 1 , , , cord-010092-uftc8inx 9584 2 S S NNP cord-010092-uftc8inx 9584 3 - - HYPH cord-010092-uftc8inx 9584 4 s s NNP cord-010092-uftc8inx 9584 5 - - HYPH cord-010092-uftc8inx 9584 6 U- U- NNP cord-010092-uftc8inx 9584 7 , , , cord-010092-uftc8inx 9584 8 Vel Vel NNP cord-010092-uftc8inx 9584 9 null null NN cord-010092-uftc8inx 9584 10 , , , cord-010092-uftc8inx 9584 11 Co co NN cord-010092-uftc8inx 9584 12 null null JJ cord-010092-uftc8inx 9585 1 and and CC cord-010092-uftc8inx 9585 2 RHCE*c.667 RHCE*c.667 NNP cord-010092-uftc8inx 9585 3 G g NN cord-010092-uftc8inx 9585 4 > > XX cord-010092-uftc8inx 9586 1 T T NNP cord-010092-uftc8inx 9586 2 were be VBD cord-010092-uftc8inx 9586 3 tested test VBN cord-010092-uftc8inx 9586 4 by by IN cord-010092-uftc8inx 9586 5 PCR PCR NNP cord-010092-uftc8inx 9586 6 - - HYPH cord-010092-uftc8inx 9586 7 SSP SSP NNP cord-010092-uftc8inx 9586 8 . . . cord-010092-uftc8inx 9587 1 A a DT cord-010092-uftc8inx 9587 2 total total NN cord-010092-uftc8inx 9587 3 of of IN cord-010092-uftc8inx 9587 4 1111 1111 CD cord-010092-uftc8inx 9587 5 probands proband NNS cord-010092-uftc8inx 9587 6 including include VBG cord-010092-uftc8inx 9587 7 800 800 CD cord-010092-uftc8inx 9587 8 individuals individual NNS cord-010092-uftc8inx 9587 9 from from IN cord-010092-uftc8inx 9587 10 Syria Syria NNP cord-010092-uftc8inx 9587 11 , , , cord-010092-uftc8inx 9587 12 147 147 CD cord-010092-uftc8inx 9587 13 from from IN cord-010092-uftc8inx 9587 14 Iran Iran NNP cord-010092-uftc8inx 9587 15 , , , cord-010092-uftc8inx 9587 16 123 123 CD cord-010092-uftc8inx 9587 17 from from IN cord-010092-uftc8inx 9587 18 the the DT cord-010092-uftc8inx 9587 19 Arabian Arabian NNP cord-010092-uftc8inx 9587 20 Peninsula Peninsula NNP cord-010092-uftc8inx 9587 21 and and CC cord-010092-uftc8inx 9587 22 41 41 CD cord-010092-uftc8inx 9587 23 from from IN cord-010092-uftc8inx 9587 24 Northern northern JJ cord-010092-uftc8inx 9587 25 African african JJ cord-010092-uftc8inx 9587 26 countries country NNS cord-010092-uftc8inx 9587 27 were be VBD cord-010092-uftc8inx 9587 28 included include VBN cord-010092-uftc8inx 9587 29 . . . cord-010092-uftc8inx 9588 1 Results result NNS cord-010092-uftc8inx 9588 2 : : : cord-010092-uftc8inx 9589 1 2 2 CD cord-010092-uftc8inx 9589 2 % % NN cord-010092-uftc8inx 9589 3 of of IN cord-010092-uftc8inx 9589 4 the the DT cord-010092-uftc8inx 9589 5 donors donor NNS cord-010092-uftc8inx 9589 6 were be VBD cord-010092-uftc8inx 9589 7 homozygous homozygous JJ cord-010092-uftc8inx 9589 8 for for IN cord-010092-uftc8inx 9589 9 the the DT cord-010092-uftc8inx 9589 10 Fy Fy NNP cord-010092-uftc8inx 9589 11 null null NN cord-010092-uftc8inx 9589 12 ( ( -LRB- cord-010092-uftc8inx 9589 13 FY*-67t fy*-67t NN cord-010092-uftc8inx 9589 14 > > XX cord-010092-uftc8inx 9589 15 c c NN cord-010092-uftc8inx 9589 16 , , , cord-010092-uftc8inx 9589 17 FY*02N.01 fy*02n.01 LS cord-010092-uftc8inx 9589 18 ) ) -RRB- cord-010092-uftc8inx 9589 19 mutation mutation NN cord-010092-uftc8inx 9589 20 , , , cord-010092-uftc8inx 9589 21 16.2 16.2 CD cord-010092-uftc8inx 9589 22 % % NN cord-010092-uftc8inx 9589 23 carried carry VBD cord-010092-uftc8inx 9589 24 the the DT cord-010092-uftc8inx 9589 25 heterozygous heterozygous JJ cord-010092-uftc8inx 9589 26 mutation mutation NN cord-010092-uftc8inx 9589 27 . . . cord-010092-uftc8inx 9590 1 0.4 0.4 CD cord-010092-uftc8inx 9590 2 % % NN cord-010092-uftc8inx 9590 3 of of IN cord-010092-uftc8inx 9590 4 the the DT cord-010092-uftc8inx 9590 5 Syrian syrian JJ cord-010092-uftc8inx 9590 6 probands proband NNS cord-010092-uftc8inx 9590 7 were be VBD cord-010092-uftc8inx 9590 8 heterozygous heterozygous JJ cord-010092-uftc8inx 9590 9 for for IN cord-010092-uftc8inx 9590 10 the the DT cord-010092-uftc8inx 9590 11 DO*350C do*350c NN cord-010092-uftc8inx 9590 12 > > XX cord-010092-uftc8inx 9590 13 T t NN cord-010092-uftc8inx 9590 14 mutation mutation NN cord-010092-uftc8inx 9590 15 ( ( -LRB- cord-010092-uftc8inx 9590 16 both both DT cord-010092-uftc8inx 9590 17 , , , cord-010092-uftc8inx 9590 18 DO*JO1 DO*JO1 NNS cord-010092-uftc8inx 9590 19 and and CC cord-010092-uftc8inx 9590 20 DO*JO2 do*jo2 NN cord-010092-uftc8inx 9590 21 ; ; . cord-010092-uftc8inx 9591 1 Jo(a+/ Jo(a+/ NNP cord-010092-uftc8inx 9591 2 a- a- NNP cord-010092-uftc8inx 9591 3 ) ) -RRB- cord-010092-uftc8inx 9591 4 ) ) -RRB- cord-010092-uftc8inx 9591 5 that that WDT cord-010092-uftc8inx 9591 6 is be VBZ cord-010092-uftc8inx 9591 7 virtually virtually RB cord-010092-uftc8inx 9591 8 unknown unknown JJ cord-010092-uftc8inx 9591 9 in in IN cord-010092-uftc8inx 9591 10 Caucasian caucasian JJ cord-010092-uftc8inx 9591 11 donors donor NNS cord-010092-uftc8inx 9591 12 . . . cord-010092-uftc8inx 9592 1 0.8 0.8 CD cord-010092-uftc8inx 9592 2 % % NN cord-010092-uftc8inx 9592 3 of of IN cord-010092-uftc8inx 9592 4 the the DT cord-010092-uftc8inx 9592 5 Syrian syrian JJ cord-010092-uftc8inx 9592 6 donors donor NNS cord-010092-uftc8inx 9592 7 heterozygously heterozygously NN cord-010092-uftc8inx 9592 8 carried carry VBD cord-010092-uftc8inx 9592 9 the the DT cord-010092-uftc8inx 9592 10 KEL*02.06 KEL*02.06 NNP cord-010092-uftc8inx 9592 11 allele allele NN cord-010092-uftc8inx 9592 12 coding coding NN cord-010092-uftc8inx 9592 13 for for IN cord-010092-uftc8inx 9592 14 Js(a Js(a NNP cord-010092-uftc8inx 9592 15 ) ) -RRB- cord-010092-uftc8inx 9593 1 ( ( -LRB- cord-010092-uftc8inx 9593 2 phenotype phenotype NN cord-010092-uftc8inx 9593 3 Js(a+/ Js(a+/ NNP cord-010092-uftc8inx 9593 4 b+ b+ NNP cord-010092-uftc8inx 9593 5 ) ) -RRB- cord-010092-uftc8inx 9593 6 ) ) -RRB- cord-010092-uftc8inx 9594 1 that that DT cord-010092-uftc8inx 9594 2 is be VBZ cord-010092-uftc8inx 9594 3 very very RB cord-010092-uftc8inx 9594 4 rare rare JJ cord-010092-uftc8inx 9594 5 in in IN cord-010092-uftc8inx 9594 6 Caucasians Caucasians NNPS cord-010092-uftc8inx 9594 7 . . . cord-010092-uftc8inx 9595 1 However however RB cord-010092-uftc8inx 9595 2 , , , cord-010092-uftc8inx 9595 3 no no DT cord-010092-uftc8inx 9595 4 homozygous homozygous JJ cord-010092-uftc8inx 9595 5 KEL*02.06 KEL*02.06 NNP cord-010092-uftc8inx 9595 6 carriers carrier NNS cord-010092-uftc8inx 9595 7 were be VBD cord-010092-uftc8inx 9595 8 identified identify VBN cord-010092-uftc8inx 9595 9 . . . cord-010092-uftc8inx 9596 1 1.8 1.8 CD cord-010092-uftc8inx 9596 2 % % NN cord-010092-uftc8inx 9596 3 of of IN cord-010092-uftc8inx 9596 4 the the DT cord-010092-uftc8inx 9596 5 Syrian syrian JJ cord-010092-uftc8inx 9596 6 and and CC cord-010092-uftc8inx 9596 7 1.5 1.5 CD cord-010092-uftc8inx 9596 8 % % NN cord-010092-uftc8inx 9596 9 of of IN cord-010092-uftc8inx 9596 10 all all DT cord-010092-uftc8inx 9596 11 donors donor NNS cord-010092-uftc8inx 9596 12 were be VBD cord-010092-uftc8inx 9596 13 negative negative JJ cord-010092-uftc8inx 9596 14 for for IN cord-010092-uftc8inx 9596 15 YT*A YT*A NNP cord-010092-uftc8inx 9596 16 , , , cord-010092-uftc8inx 9596 17 which which WDT cord-010092-uftc8inx 9596 18 is be VBZ cord-010092-uftc8inx 9596 19 definitely definitely RB cord-010092-uftc8inx 9596 20 more more RBR cord-010092-uftc8inx 9596 21 frequent frequent JJ cord-010092-uftc8inx 9596 22 than than IN cord-010092-uftc8inx 9596 23 in in IN cord-010092-uftc8inx 9596 24 Europeans Europeans NNPS cord-010092-uftc8inx 9596 25 . . . cord-010092-uftc8inx 9597 1 One one CD cord-010092-uftc8inx 9597 2 donor donor NN cord-010092-uftc8inx 9597 3 from from IN cord-010092-uftc8inx 9597 4 Northern Northern NNP cord-010092-uftc8inx 9597 5 Africa Africa NNP cord-010092-uftc8inx 9597 6 homozygously homozygously NN cord-010092-uftc8inx 9597 7 carried carry VBD cord-010092-uftc8inx 9597 8 the the DT cord-010092-uftc8inx 9597 9 GYPB*c.251C gypb*c.251c CD cord-010092-uftc8inx 9597 10 > > SYM cord-010092-uftc8inx 9597 11 G g NN cord-010092-uftc8inx 9597 12 , , , cord-010092-uftc8inx 9597 13 intron intron NN cord-010092-uftc8inx 9597 14 5 5 CD cord-010092-uftc8inx 9597 15 + + SYM cord-010092-uftc8inx 9597 16 5 5 CD cord-010092-uftc8inx 9597 17 g g NN cord-010092-uftc8inx 9597 18 mutation mutation NN cord-010092-uftc8inx 9597 19 , , , cord-010092-uftc8inx 9597 20 inducing induce VBG cord-010092-uftc8inx 9597 21 the the DT cord-010092-uftc8inx 9597 22 S S NNP cord-010092-uftc8inx 9597 23 - - HYPH cord-010092-uftc8inx 9597 24 U+ U+ NNP cord-010092-uftc8inx 9597 25 w w NN cord-010092-uftc8inx 9597 26 phenotype phenotype NN cord-010092-uftc8inx 9597 27 . . . cord-010092-uftc8inx 9598 1 3.6 3.6 CD cord-010092-uftc8inx 9598 2 % % NN cord-010092-uftc8inx 9598 3 of of IN cord-010092-uftc8inx 9598 4 all all DT cord-010092-uftc8inx 9598 5 and and CC cord-010092-uftc8inx 9598 6 29.3 29.3 CD cord-010092-uftc8inx 9598 7 % % NN cord-010092-uftc8inx 9598 8 of of IN cord-010092-uftc8inx 9598 9 Northern northern JJ cord-010092-uftc8inx 9598 10 African african JJ cord-010092-uftc8inx 9598 11 donors donor NNS cord-010092-uftc8inx 9598 12 were be VBD cord-010092-uftc8inx 9598 13 heterozygous heterozygous JJ cord-010092-uftc8inx 9598 14 for for IN cord-010092-uftc8inx 9598 15 the the DT cord-010092-uftc8inx 9598 16 RHCE*c.733C rhce*c.733c CD cord-010092-uftc8inx 9598 17 > > SYM cord-010092-uftc8inx 9598 18 G g NN cord-010092-uftc8inx 9598 19 substitution substitution NN cord-010092-uftc8inx 9598 20 , , , cord-010092-uftc8inx 9598 21 0.3 0.3 CD cord-010092-uftc8inx 9598 22 % % NN cord-010092-uftc8inx 9598 23 of of IN cord-010092-uftc8inx 9598 24 the the DT cord-010092-uftc8inx 9598 25 Syrian syrian JJ cord-010092-uftc8inx 9598 26 donors donor NNS cord-010092-uftc8inx 9598 27 carried carry VBD cord-010092-uftc8inx 9598 28 RHCE*c.697C rhce*c.697c CD cord-010092-uftc8inx 9598 29 > > XX cord-010092-uftc8inx 9598 30 G G NNP cord-010092-uftc8inx 9598 31 ( ( -LRB- cord-010092-uftc8inx 9598 32 heterozygously heterozygously NNP cord-010092-uftc8inx 9598 33 ) ) -RRB- cord-010092-uftc8inx 9598 34 and and CC cord-010092-uftc8inx 9598 35 0.004 0.004 CD cord-010092-uftc8inx 9598 36 % % NN cord-010092-uftc8inx 9598 37 of of IN cord-010092-uftc8inx 9598 38 all all DT cord-010092-uftc8inx 9598 39 donors donor NNS cord-010092-uftc8inx 9598 40 were be VBD cord-010092-uftc8inx 9598 41 heterozygous heterozygous JJ cord-010092-uftc8inx 9598 42 for for IN cord-010092-uftc8inx 9598 43 RHCE*667 rhce*667 NN cord-010092-uftc8inx 9598 44 G g NN cord-010092-uftc8inx 9599 1 > > XX cord-010092-uftc8inx 9600 1 T. T. NNP cord-010092-uftc8inx 9600 2 Heterozygosity Heterozygosity NNP cord-010092-uftc8inx 9600 3 for for IN cord-010092-uftc8inx 9600 4 Vel Vel NNP cord-010092-uftc8inx 9600 5 deficiency deficiency NN cord-010092-uftc8inx 9600 6 ( ( -LRB- cord-010092-uftc8inx 9600 7 VEL*-01 VEL*-01 NNP cord-010092-uftc8inx 9600 8 ) ) -RRB- cord-010092-uftc8inx 9600 9 was be VBD cord-010092-uftc8inx 9600 10 detected detect VBN cord-010092-uftc8inx 9600 11 in in IN cord-010092-uftc8inx 9600 12 21 21 CD cord-010092-uftc8inx 9600 13 individuals individual NNS cord-010092-uftc8inx 9600 14 ( ( -LRB- cord-010092-uftc8inx 9600 15 2 2 CD cord-010092-uftc8inx 9600 16 % % NN cord-010092-uftc8inx 9600 17 ; ; : cord-010092-uftc8inx 9600 18 16 16 CD cord-010092-uftc8inx 9600 19 of of IN cord-010092-uftc8inx 9600 20 them -PRON- PRP cord-010092-uftc8inx 9600 21 from from IN cord-010092-uftc8inx 9600 22 Syria Syria NNP cord-010092-uftc8inx 9600 23 ) ) -RRB- cord-010092-uftc8inx 9600 24 whereas whereas IN cord-010092-uftc8inx 9600 25 only only RB cord-010092-uftc8inx 9600 26 one one CD cord-010092-uftc8inx 9600 27 Syrian syrian JJ cord-010092-uftc8inx 9600 28 donor donor NN cord-010092-uftc8inx 9600 29 carried carry VBD cord-010092-uftc8inx 9600 30 the the DT cord-010092-uftc8inx 9600 31 homozygous homozygous JJ cord-010092-uftc8inx 9600 32 mutation mutation NN cord-010092-uftc8inx 9600 33 . . . cord-010092-uftc8inx 9601 1 None none NN cord-010092-uftc8inx 9601 2 of of IN cord-010092-uftc8inx 9601 3 the the DT cord-010092-uftc8inx 9601 4 donors donor NNS cord-010092-uftc8inx 9601 5 carried carry VBD cord-010092-uftc8inx 9601 6 the the DT cord-010092-uftc8inx 9601 7 AQP1*c.601delG AQP1*c.601delG NNP cord-010092-uftc8inx 9601 8 ( ( -LRB- cord-010092-uftc8inx 9601 9 CO*01N.06 CO*01N.06 NNP cord-010092-uftc8inx 9601 10 ) ) -RRB- cord-010092-uftc8inx 9601 11 mutation mutation NN cord-010092-uftc8inx 9601 12 that that WDT cord-010092-uftc8inx 9601 13 induces induce VBZ cord-010092-uftc8inx 9601 14 the the DT cord-010092-uftc8inx 9601 15 Co Co NNP cord-010092-uftc8inx 9601 16 null null JJ cord-010092-uftc8inx 9601 17 phenotype phenotype NN cord-010092-uftc8inx 9601 18 . . . cord-010092-uftc8inx 9602 1 Summary Summary NNP cord-010092-uftc8inx 9602 2 / / SYM cord-010092-uftc8inx 9602 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 9602 4 : : : cord-010092-uftc8inx 9603 1 The the DT cord-010092-uftc8inx 9603 2 study study NN cord-010092-uftc8inx 9603 3 provides provide VBZ cord-010092-uftc8inx 9603 4 a a DT cord-010092-uftc8inx 9603 5 first first JJ cord-010092-uftc8inx 9603 6 overview overview NN cord-010092-uftc8inx 9603 7 on on IN cord-010092-uftc8inx 9603 8 a a DT cord-010092-uftc8inx 9603 9 number number NN cord-010092-uftc8inx 9603 10 of of IN cord-010092-uftc8inx 9603 11 different different JJ cord-010092-uftc8inx 9603 12 blood blood NN cord-010092-uftc8inx 9603 13 group group NN cord-010092-uftc8inx 9603 14 alleles allele NNS cord-010092-uftc8inx 9603 15 in in IN cord-010092-uftc8inx 9603 16 blood blood NN cord-010092-uftc8inx 9603 17 donors donor NNS cord-010092-uftc8inx 9603 18 from from IN cord-010092-uftc8inx 9603 19 Arabian arabian JJ cord-010092-uftc8inx 9603 20 countries country NNS cord-010092-uftc8inx 9603 21 . . . cord-010092-uftc8inx 9604 1 Some some DT cord-010092-uftc8inx 9604 2 blood blood NN cord-010092-uftc8inx 9604 3 group group NN cord-010092-uftc8inx 9604 4 alleles allele NNS cord-010092-uftc8inx 9604 5 that that WDT cord-010092-uftc8inx 9604 6 largely largely RB cord-010092-uftc8inx 9604 7 are be VBP cord-010092-uftc8inx 9604 8 lacking lack VBG cord-010092-uftc8inx 9604 9 in in IN cord-010092-uftc8inx 9604 10 Europeans Europeans NNPS cord-010092-uftc8inx 9604 11 but but CC cord-010092-uftc8inx 9604 12 had have VBD cord-010092-uftc8inx 9604 13 been be VBN cord-010092-uftc8inx 9604 14 described describe VBN cord-010092-uftc8inx 9604 15 in in IN cord-010092-uftc8inx 9604 16 African african JJ cord-010092-uftc8inx 9604 17 individuals individual NNS cord-010092-uftc8inx 9604 18 are be VBP cord-010092-uftc8inx 9604 19 present present JJ cord-010092-uftc8inx 9604 20 in in IN cord-010092-uftc8inx 9604 21 Arabian arabian JJ cord-010092-uftc8inx 9604 22 populations population NNS cord-010092-uftc8inx 9604 23 at at IN cord-010092-uftc8inx 9604 24 a a DT cord-010092-uftc8inx 9604 25 somewhat somewhat RB cord-010092-uftc8inx 9604 26 lower low JJR cord-010092-uftc8inx 9604 27 frequency frequency NN cord-010092-uftc8inx 9604 28 . . . cord-010092-uftc8inx 9605 1 In in IN cord-010092-uftc8inx 9605 2 single single JJ cord-010092-uftc8inx 9605 3 cases case NNS cord-010092-uftc8inx 9605 4 it -PRON- PRP cord-010092-uftc8inx 9605 5 could could MD cord-010092-uftc8inx 9605 6 be be VB cord-010092-uftc8inx 9605 7 challenging challenge VBG cord-010092-uftc8inx 9605 8 to to TO cord-010092-uftc8inx 9605 9 provide provide VB cord-010092-uftc8inx 9605 10 immunized immunize VBN cord-010092-uftc8inx 9605 11 Arabian arabian JJ cord-010092-uftc8inx 9605 12 patients patient NNS cord-010092-uftc8inx 9605 13 with with IN cord-010092-uftc8inx 9605 14 compatible compatible JJ cord-010092-uftc8inx 9605 15 blood blood NN cord-010092-uftc8inx 9605 16 . . . cord-010092-uftc8inx 9606 1 Methods method NNS cord-010092-uftc8inx 9606 2 : : : cord-010092-uftc8inx 9607 1 Three three CD cord-010092-uftc8inx 9607 2 unrelated unrelated JJ cord-010092-uftc8inx 9607 3 individuals individual NNS cord-010092-uftc8inx 9607 4 ( ( -LRB- cord-010092-uftc8inx 9607 5 2 2 CD cord-010092-uftc8inx 9607 6 blood blood NN cord-010092-uftc8inx 9607 7 donors donor NNS cord-010092-uftc8inx 9607 8 and and CC cord-010092-uftc8inx 9607 9 one one CD cord-010092-uftc8inx 9607 10 pregnant pregnant JJ cord-010092-uftc8inx 9607 11 woman woman NN cord-010092-uftc8inx 9607 12 ) ) -RRB- cord-010092-uftc8inx 9607 13 of of IN cord-010092-uftc8inx 9607 14 Polish polish JJ cord-010092-uftc8inx 9607 15 origin origin NN cord-010092-uftc8inx 9607 16 who who WP cord-010092-uftc8inx 9607 17 were be VBD cord-010092-uftc8inx 9607 18 typed type VBN cord-010092-uftc8inx 9607 19 as as IN cord-010092-uftc8inx 9607 20 AB AB NNP cord-010092-uftc8inx 9607 21 group group NN cord-010092-uftc8inx 9607 22 with with IN cord-010092-uftc8inx 9607 23 a a DT cord-010092-uftc8inx 9607 24 very very RB cord-010092-uftc8inx 9607 25 weak weak JJ cord-010092-uftc8inx 9607 26 A a DT cord-010092-uftc8inx 9607 27 antigen antigen NN cord-010092-uftc8inx 9607 28 and and CC cord-010092-uftc8inx 9607 29 normal normal JJ cord-010092-uftc8inx 9607 30 B b NN cord-010092-uftc8inx 9607 31 antigen antigen NN cord-010092-uftc8inx 9607 32 expression expression NN cord-010092-uftc8inx 9607 33 were be VBD cord-010092-uftc8inx 9607 34 subjected subject VBN cord-010092-uftc8inx 9607 35 to to IN cord-010092-uftc8inx 9607 36 extended extend VBN cord-010092-uftc8inx 9607 37 ABO ABO NNP cord-010092-uftc8inx 9607 38 typing typing NN cord-010092-uftc8inx 9607 39 . . . cord-010092-uftc8inx 9608 1 In in IN cord-010092-uftc8inx 9608 2 one one CD cord-010092-uftc8inx 9608 3 case case NN cord-010092-uftc8inx 9608 4 family family NN cord-010092-uftc8inx 9608 5 studies study NNS cord-010092-uftc8inx 9608 6 were be VBD cord-010092-uftc8inx 9608 7 performed perform VBN cord-010092-uftc8inx 9608 8 ( ( -LRB- cord-010092-uftc8inx 9608 9 blood blood NN cord-010092-uftc8inx 9608 10 samples sample NNS cord-010092-uftc8inx 9608 11 from from IN cord-010092-uftc8inx 9608 12 donor donor NN cord-010092-uftc8inx 9608 13 's 's POS cord-010092-uftc8inx 9608 14 mother mother NN cord-010092-uftc8inx 9608 15 , , , cord-010092-uftc8inx 9608 16 father father NN cord-010092-uftc8inx 9608 17 and and CC cord-010092-uftc8inx 9608 18 sister sister NN cord-010092-uftc8inx 9608 19 ) ) -RRB- cord-010092-uftc8inx 9608 20 . . . cord-010092-uftc8inx 9609 1 Sequencing sequencing NN cord-010092-uftc8inx 9609 2 analysis analysis NN cord-010092-uftc8inx 9609 3 of of IN cord-010092-uftc8inx 9609 4 this this DT cord-010092-uftc8inx 9609 5 donor donor NN cord-010092-uftc8inx 9609 6 DNA dna NN cord-010092-uftc8inx 9609 7 was be VBD cord-010092-uftc8inx 9609 8 performed perform VBN cord-010092-uftc8inx 9609 9 three three CD cord-010092-uftc8inx 9609 10 times time NNS cord-010092-uftc8inx 9609 11 ( ( -LRB- cord-010092-uftc8inx 9609 12 from from IN cord-010092-uftc8inx 9609 13 two two CD cord-010092-uftc8inx 9609 14 blood blood NN cord-010092-uftc8inx 9609 15 samples sample NNS cord-010092-uftc8inx 9609 16 and and CC cord-010092-uftc8inx 9609 17 buccal buccal JJ cord-010092-uftc8inx 9609 18 swab swab NN cord-010092-uftc8inx 9609 19 ) ) -RRB- cord-010092-uftc8inx 9609 20 . . . cord-010092-uftc8inx 9610 1 Serologic Serologic NNP cord-010092-uftc8inx 9610 2 investigations investigation NNS cord-010092-uftc8inx 9610 3 were be VBD cord-010092-uftc8inx 9610 4 performed perform VBN cord-010092-uftc8inx 9610 5 with with IN cord-010092-uftc8inx 9610 6 standard standard JJ cord-010092-uftc8inx 9610 7 methods method NNS cord-010092-uftc8inx 9610 8 : : : cord-010092-uftc8inx 9610 9 1 1 CD cord-010092-uftc8inx 9610 10 / / SYM cord-010092-uftc8inx 9610 11 gel gel NN cord-010092-uftc8inx 9610 12 cards card NNS cord-010092-uftc8inx 9611 1 DiaClon DiaClon NNP cord-010092-uftc8inx 9611 2 ID ID NNP cord-010092-uftc8inx 9612 1 ABO ABO NNP cord-010092-uftc8inx 9612 2 / / SYM cord-010092-uftc8inx 9612 3 D D NNP cord-010092-uftc8inx 9612 4 ( ( -LRB- cord-010092-uftc8inx 9612 5 anti anti JJ cord-010092-uftc8inx 9612 6 - - JJ cord-010092-uftc8inx 9612 7 A a NN cord-010092-uftc8inx 9612 8 : : : cord-010092-uftc8inx 9612 9 clone clone NN cord-010092-uftc8inx 9612 10 A5 a5 NN cord-010092-uftc8inx 9612 11 , , , cord-010092-uftc8inx 9612 12 anti anti NN cord-010092-uftc8inx 9612 13 - - NN cord-010092-uftc8inx 9612 14 B b NN cord-010092-uftc8inx 9612 15 : : : cord-010092-uftc8inx 9612 16 clone clone NN cord-010092-uftc8inx 9612 17 G1/2 G1/2 NNP cord-010092-uftc8inx 9612 18 , , , cord-010092-uftc8inx 9612 19 anti anti JJ cord-010092-uftc8inx 9612 20 - - JJ cord-010092-uftc8inx 9612 21 A a NN cord-010092-uftc8inx 9612 22 , , , cord-010092-uftc8inx 9612 23 B b NN cord-010092-uftc8inx 9612 24 : : : cord-010092-uftc8inx 9612 25 clone clone NN cord-010092-uftc8inx 9612 26 ES131 ES131 NNP cord-010092-uftc8inx 9612 27 , , . cord-010092-uftc8inx 9613 1 ES15 ES15 NNP cord-010092-uftc8inx 9613 2 + + SYM cord-010092-uftc8inx 9613 3 BIRMA BIRMA NNP cord-010092-uftc8inx 9613 4 1 1 CD cord-010092-uftc8inx 9613 5 + + CC cord-010092-uftc8inx 9613 6 ES4 es4 NN cord-010092-uftc8inx 9613 7 ; ; : cord-010092-uftc8inx 9613 8 Bio Bio NNP cord-010092-uftc8inx 9613 9 - - HYPH cord-010092-uftc8inx 9613 10 Rad Rad NNP cord-010092-uftc8inx 9613 11 ) ) -RRB- cord-010092-uftc8inx 9613 12 and and CC cord-010092-uftc8inx 9613 13 DiaClon DiaClon NNP cord-010092-uftc8inx 9613 14 ID ID NNP cord-010092-uftc8inx 9613 15 ABD ABD NNP cord-010092-uftc8inx 9613 16 - - HYPH cord-010092-uftc8inx 9613 17 Confirmation Confirmation NNP cord-010092-uftc8inx 9613 18 for for IN cord-010092-uftc8inx 9613 19 Donors Donors NNPS cord-010092-uftc8inx 9613 20 ( ( -LRB- cord-010092-uftc8inx 9613 21 anti anti JJ cord-010092-uftc8inx 9613 22 - - JJ cord-010092-uftc8inx 9613 23 A a NN cord-010092-uftc8inx 9613 24 : : : cord-010092-uftc8inx 9614 1 clone clone NN cord-010092-uftc8inx 9614 2 M297/628 M297/628 NNP cord-010092-uftc8inx 9614 3 = = SYM cord-010092-uftc8inx 9614 4 LA-2 LA-2 NNP cord-010092-uftc8inx 9614 5 ; ; : cord-010092-uftc8inx 9614 6 Bio Bio NNP cord-010092-uftc8inx 9614 7 - - HYPH cord-010092-uftc8inx 9614 8 Rad Rad NNP cord-010092-uftc8inx 9614 9 ) ) -RRB- cord-010092-uftc8inx 9614 10 ; ; : cord-010092-uftc8inx 9614 11 2 2 CD cord-010092-uftc8inx 9614 12 / / SYM cord-010092-uftc8inx 9614 13 tube tube NN cord-010092-uftc8inx 9614 14 techniques technique NNS cord-010092-uftc8inx 9614 15 with with IN cord-010092-uftc8inx 9614 16 : : : cord-010092-uftc8inx 9614 17 anti anti JJ cord-010092-uftc8inx 9614 18 - - JJ cord-010092-uftc8inx 9614 19 A a JJ cord-010092-uftc8inx 9614 20 ( ( -LRB- cord-010092-uftc8inx 9614 21 BIRMA BIRMA NNP cord-010092-uftc8inx 9614 22 1 1 CD cord-010092-uftc8inx 9614 23 ; ; : cord-010092-uftc8inx 9615 1 A-11H5 A-11H5 NNPS cord-010092-uftc8inx 9615 2 , , , cord-010092-uftc8inx 9615 3 A1 A1 NNP cord-010092-uftc8inx 9615 4 s. s. NNP cord-010092-uftc8inx 9616 1 PA1M095 PA1M095 NNP cord-010092-uftc8inx 9616 2 , , , cord-010092-uftc8inx 9616 3 c.9113D10 c.9113D10 NNP cord-010092-uftc8inx 9616 4 ) ) -RRB- cord-010092-uftc8inx 9616 5 , , , cord-010092-uftc8inx 9616 6 anti anti NN cord-010092-uftc8inx 9616 7 - - NN cord-010092-uftc8inx 9616 8 B b NN cord-010092-uftc8inx 9617 1 ( ( -LRB- cord-010092-uftc8inx 9617 2 LB-2 LB-2 NNP cord-010092-uftc8inx 9617 3 , , , cord-010092-uftc8inx 9617 4 B-6F9 B-6F9 NNP cord-010092-uftc8inx 9617 5 , , , cord-010092-uftc8inx 9617 6 c.9621A8 c.9621A8 NNP cord-010092-uftc8inx 9617 7 ) ) -RRB- cord-010092-uftc8inx 9617 8 . . . cord-010092-uftc8inx 9618 1 Genotyping Genotyping NNP cord-010092-uftc8inx 9618 2 was be VBD cord-010092-uftc8inx 9618 3 determined determine VBN cord-010092-uftc8inx 9618 4 by by IN cord-010092-uftc8inx 9618 5 RBC RBC NNP cord-010092-uftc8inx 9618 6 FluoGene FluoGene NNP cord-010092-uftc8inx 9618 7 ABO ABO NNP cord-010092-uftc8inx 9618 8 Basic Basic NNP cord-010092-uftc8inx 9618 9 Kit kit NN cord-010092-uftc8inx 9618 10 ( ( -LRB- cord-010092-uftc8inx 9618 11 Inno inno JJ cord-010092-uftc8inx 9618 12 - - HYPH cord-010092-uftc8inx 9618 13 train train NN cord-010092-uftc8inx 9618 14 , , , cord-010092-uftc8inx 9618 15 Germany Germany NNP cord-010092-uftc8inx 9618 16 ) ) -RRB- cord-010092-uftc8inx 9618 17 and and CC cord-010092-uftc8inx 9618 18 by by IN cord-010092-uftc8inx 9618 19 sequencing sequence VBG cord-010092-uftc8inx 9618 20 of of IN cord-010092-uftc8inx 9618 21 +7.21-kb +7.21-kb NNP cord-010092-uftc8inx 9618 22 site site NN cord-010092-uftc8inx 9618 23 of of IN cord-010092-uftc8inx 9618 24 ABO ABO NNP cord-010092-uftc8inx 9618 25 gene gene NN cord-010092-uftc8inx 9618 26 to to TO cord-010092-uftc8inx 9618 27 cover cover VB cord-010092-uftc8inx 9618 28 sequences sequence NNS cord-010092-uftc8inx 9618 29 ranging range VBG cord-010092-uftc8inx 9618 30 from from IN cord-010092-uftc8inx 9618 31 the the DT cord-010092-uftc8inx 9618 32 end end NN cord-010092-uftc8inx 9618 33 of of IN cord-010092-uftc8inx 9618 34 Intron Intron NNP cord-010092-uftc8inx 9618 35 1 1 CD cord-010092-uftc8inx 9618 36 to to IN cord-010092-uftc8inx 9618 37 3 3 CD cord-010092-uftc8inx 9618 38 0 0 CD cord-010092-uftc8inx 9618 39 UTR UTR NNP cord-010092-uftc8inx 9618 40 of of IN cord-010092-uftc8inx 9618 41 the the DT cord-010092-uftc8inx 9618 42 ABO ABO NNP cord-010092-uftc8inx 9618 43 gene gene NN cord-010092-uftc8inx 9618 44 . . . cord-010092-uftc8inx 9619 1 Additionally additionally RB cord-010092-uftc8inx 9619 2 sequence sequence NN cord-010092-uftc8inx 9619 3 of of IN cord-010092-uftc8inx 9619 4 Exon Exon NNP cord-010092-uftc8inx 9619 5 1 1 CD cord-010092-uftc8inx 9619 6 of of IN cord-010092-uftc8inx 9619 7 the the DT cord-010092-uftc8inx 9619 8 ABO ABO NNP cord-010092-uftc8inx 9619 9 gene gene NN cord-010092-uftc8inx 9619 10 was be VBD cord-010092-uftc8inx 9619 11 analyzed analyze VBN cord-010092-uftc8inx 9619 12 . . . cord-010092-uftc8inx 9620 1 Results result NNS cord-010092-uftc8inx 9620 2 : : : cord-010092-uftc8inx 9621 1 ABO ABO NNP cord-010092-uftc8inx 9621 2 typing typing NN cord-010092-uftc8inx 9621 3 showed show VBD cord-010092-uftc8inx 9621 4 normal normal JJ cord-010092-uftc8inx 9621 5 B b NN cord-010092-uftc8inx 9621 6 and and CC cord-010092-uftc8inx 9621 7 a a DT cord-010092-uftc8inx 9621 8 very very RB cord-010092-uftc8inx 9621 9 weak weak JJ cord-010092-uftc8inx 9621 10 A a DT cord-010092-uftc8inx 9621 11 antigens antigen NNS cord-010092-uftc8inx 9621 12 on on IN cord-010092-uftc8inx 9621 13 RBCs rbc NNS cord-010092-uftc8inx 9621 14 of of IN cord-010092-uftc8inx 9621 15 all all DT cord-010092-uftc8inx 9621 16 three three CD cord-010092-uftc8inx 9621 17 individuals individual NNS cord-010092-uftc8inx 9621 18 ( ( -LRB- cord-010092-uftc8inx 9621 19 2 2 CD cord-010092-uftc8inx 9621 20 blood blood NN cord-010092-uftc8inx 9621 21 donors donor NNS cord-010092-uftc8inx 9621 22 and and CC cord-010092-uftc8inx 9621 23 one one CD cord-010092-uftc8inx 9621 24 pregnant pregnant JJ cord-010092-uftc8inx 9621 25 woman woman NN cord-010092-uftc8inx 9621 26 ) ) -RRB- cord-010092-uftc8inx 9621 27 . . . cord-010092-uftc8inx 9622 1 The the DT cord-010092-uftc8inx 9622 2 A a DT cord-010092-uftc8inx 9622 3 antigen antigen NN cord-010092-uftc8inx 9622 4 was be VBD cord-010092-uftc8inx 9622 5 detected detect VBN cord-010092-uftc8inx 9622 6 by by IN cord-010092-uftc8inx 9622 7 tube tube NN cord-010092-uftc8inx 9622 8 technique technique NN cord-010092-uftc8inx 9622 9 only only RB cord-010092-uftc8inx 9622 10 using use VBG cord-010092-uftc8inx 9622 11 anti anti JJ cord-010092-uftc8inx 9622 12 - - JJ cord-010092-uftc8inx 9622 13 A a JJ cord-010092-uftc8inx 9622 14 clones clone NNS cord-010092-uftc8inx 9622 15 : : : cord-010092-uftc8inx 9623 1 BIRMA BIRMA NNP cord-010092-uftc8inx 9623 2 1 1 CD cord-010092-uftc8inx 9623 3 ( ( -LRB- cord-010092-uftc8inx 9623 4 1 1 CD cord-010092-uftc8inx 9623 5 + + SYM cord-010092-uftc8inx 9623 6 to to IN cord-010092-uftc8inx 9623 7 2 2 CD cord-010092-uftc8inx 9623 8 + + CD cord-010092-uftc8inx 9623 9 ) ) -RRB- cord-010092-uftc8inx 9623 10 , , . cord-010092-uftc8inx 9624 1 A-11H5 A-11H5 NNPS cord-010092-uftc8inx 9624 2 ( ( -LRB- cord-010092-uftc8inx 9624 3 1 1 CD cord-010092-uftc8inx 9624 4 + + SYM cord-010092-uftc8inx 9624 5 to to IN cord-010092-uftc8inx 9624 6 2 2 CD cord-010092-uftc8inx 9624 7 + + CD cord-010092-uftc8inx 9624 8 ) ) -RRB- cord-010092-uftc8inx 9624 9 and and CC cord-010092-uftc8inx 9624 10 c.9113D10 c.9113D10 NNP cord-010092-uftc8inx 9624 11 ( ( -LRB- cord-010092-uftc8inx 9624 12 weak+ weak+ NNP cord-010092-uftc8inx 9624 13 to to IN cord-010092-uftc8inx 9624 14 1 1 CD cord-010092-uftc8inx 9624 15 + + CD cord-010092-uftc8inx 9624 16 ) ) -RRB- cord-010092-uftc8inx 9625 1 ; ; : cord-010092-uftc8inx 9625 2 negative negative JJ cord-010092-uftc8inx 9625 3 reaction reaction NN cord-010092-uftc8inx 9625 4 of of IN cord-010092-uftc8inx 9625 5 A a DT cord-010092-uftc8inx 9625 6 antigen antigen NN cord-010092-uftc8inx 9625 7 typing type VBG cord-010092-uftc8inx 9625 8 by by IN cord-010092-uftc8inx 9625 9 gel gel NN cord-010092-uftc8inx 9625 10 cards card NNS cord-010092-uftc8inx 9625 11 was be VBD cord-010092-uftc8inx 9625 12 observed observe VBN cord-010092-uftc8inx 9625 13 . . . cord-010092-uftc8inx 9626 1 The the DT cord-010092-uftc8inx 9626 2 sera sera NN cord-010092-uftc8inx 9626 3 of of IN cord-010092-uftc8inx 9626 4 all all DT cord-010092-uftc8inx 9626 5 individuals individual NNS cord-010092-uftc8inx 9626 6 contained contain VBD cord-010092-uftc8inx 9626 7 anti anti JJ cord-010092-uftc8inx 9626 8 - - JJ cord-010092-uftc8inx 9626 9 A1 a1 JJ cord-010092-uftc8inx 9626 10 antibodies antibody NNS cord-010092-uftc8inx 9626 11 . . . cord-010092-uftc8inx 9627 1 Commercial commercial JJ cord-010092-uftc8inx 9627 2 PCR PCR NNP cord-010092-uftc8inx 9627 3 - - HYPH cord-010092-uftc8inx 9627 4 SSP SSP NNP cord-010092-uftc8inx 9627 5 kit kit NN cord-010092-uftc8inx 9627 6 revealed reveal VBD cord-010092-uftc8inx 9627 7 three three CD cord-010092-uftc8inx 9627 8 heterozygous heterozygous JJ cord-010092-uftc8inx 9627 9 A A NNP cord-010092-uftc8inx 9627 10 / / SYM cord-010092-uftc8inx 9627 11 B b NN cord-010092-uftc8inx 9627 12 genotypes genotype NNS cord-010092-uftc8inx 9627 13 ( ( -LRB- cord-010092-uftc8inx 9627 14 absence absence NN cord-010092-uftc8inx 9627 15 of of IN cord-010092-uftc8inx 9627 16 1061delC 1061delc CD cord-010092-uftc8inx 9627 17 typical typical NN cord-010092-uftc8inx 9627 18 for for IN cord-010092-uftc8inx 9627 19 ABO*A2 abo*a2 CD cord-010092-uftc8inx 9627 20 alleles allele NNS cord-010092-uftc8inx 9627 21 ) ) -RRB- cord-010092-uftc8inx 9627 22 . . . cord-010092-uftc8inx 9628 1 In in IN cord-010092-uftc8inx 9628 2 all all PDT cord-010092-uftc8inx 9628 3 these these DT cord-010092-uftc8inx 9628 4 individuals individual NNS cord-010092-uftc8inx 9628 5 ABO ABO NNP cord-010092-uftc8inx 9628 6 sequencing sequencing NN cord-010092-uftc8inx 9628 7 of of IN cord-010092-uftc8inx 9628 8 7.21-kb 7.21-kb CD cord-010092-uftc8inx 9628 9 fragment fragment NN cord-010092-uftc8inx 9628 10 confirmed confirm VBD cord-010092-uftc8inx 9628 11 the the DT cord-010092-uftc8inx 9628 12 heterozygous heterozygous JJ cord-010092-uftc8inx 9628 13 genotype genotype NN cord-010092-uftc8inx 9628 14 with with IN cord-010092-uftc8inx 9628 15 7 7 CD cord-010092-uftc8inx 9628 16 polymorphisms polymorphism NNS cord-010092-uftc8inx 9628 17 characteristic characteristic JJ cord-010092-uftc8inx 9628 18 for for IN cord-010092-uftc8inx 9628 19 ABO*B.01 ABO*B.01 NNP cord-010092-uftc8inx 9628 20 allele allele NN cord-010092-uftc8inx 9628 21 ( ( -LRB- cord-010092-uftc8inx 9628 22 297A 297a CD cord-010092-uftc8inx 9629 1 > > XX cord-010092-uftc8inx 9629 2 G g NN cord-010092-uftc8inx 9629 3 ; ; : cord-010092-uftc8inx 9629 4 526C 526c XX cord-010092-uftc8inx 9629 5 > > XX cord-010092-uftc8inx 9629 6 G g NN cord-010092-uftc8inx 9629 7 ; ; : cord-010092-uftc8inx 9629 8 657C 657c CD cord-010092-uftc8inx 9630 1 > > XX cord-010092-uftc8inx 9631 1 T T NNP cord-010092-uftc8inx 9631 2 ; ; : cord-010092-uftc8inx 9631 3 703G 703G NNP cord-010092-uftc8inx 9631 4 > > XX cord-010092-uftc8inx 9631 5 A a NN cord-010092-uftc8inx 9631 6 ; ; . cord-010092-uftc8inx 9632 1 796C 796C NNP cord-010092-uftc8inx 9632 2 > > XX cord-010092-uftc8inx 9633 1 A a LS cord-010092-uftc8inx 9633 2 ; ; : cord-010092-uftc8inx 9633 3 803G 803G NNP cord-010092-uftc8inx 9633 4 > > XX cord-010092-uftc8inx 9633 5 C c NN cord-010092-uftc8inx 9633 6 ; ; : cord-010092-uftc8inx 9633 7 930G 930g XX cord-010092-uftc8inx 9633 8 > > XX cord-010092-uftc8inx 9633 9 A a DT cord-010092-uftc8inx 9633 10 ) ) -RRB- cord-010092-uftc8inx 9633 11 and and CC cord-010092-uftc8inx 9633 12 detected detect VBD cord-010092-uftc8inx 9633 13 a a DT cord-010092-uftc8inx 9633 14 novel novel JJ cord-010092-uftc8inx 9633 15 ABO*A ABO*A NNP cord-010092-uftc8inx 9633 16 allele allele NN cord-010092-uftc8inx 9633 17 sequence sequence NN cord-010092-uftc8inx 9633 18 with with IN cord-010092-uftc8inx 9633 19 duplication duplication NN cord-010092-uftc8inx 9633 20 - - HYPH cord-010092-uftc8inx 9633 21 based base VBN cord-010092-uftc8inx 9633 22 insertion insertion NN cord-010092-uftc8inx 9633 23 of of IN cord-010092-uftc8inx 9633 24 21 21 CD cord-010092-uftc8inx 9633 25 bp bp NN cord-010092-uftc8inx 9633 26 after after IN cord-010092-uftc8inx 9633 27 564 564 CD cord-010092-uftc8inx 9633 28 position position NN cord-010092-uftc8inx 9633 29 ( ( -LRB- cord-010092-uftc8inx 9633 30 ABO*A ABO*A NNP cord-010092-uftc8inx 9633 31 c.dup543_563 c.dup543_563 CD cord-010092-uftc8inx 9633 32 ; ; : cord-010092-uftc8inx 9633 33 GCAGGACGTGTCCATGCGCCG GCAGGACGTGTCCATGCGCCG NNP cord-010092-uftc8inx 9633 34 ) ) -RRB- cord-010092-uftc8inx 9633 35 . . . cord-010092-uftc8inx 9634 1 As as IN cord-010092-uftc8inx 9634 2 a a DT cord-010092-uftc8inx 9634 3 consequence consequence NN cord-010092-uftc8inx 9634 4 , , , cord-010092-uftc8inx 9634 5 the the DT cord-010092-uftc8inx 9634 6 online online JJ cord-010092-uftc8inx 9634 7 protein protein NN cord-010092-uftc8inx 9634 8 translation translation NN cord-010092-uftc8inx 9634 9 predicts predict VBZ cord-010092-uftc8inx 9634 10 an an DT cord-010092-uftc8inx 9634 11 in in IN cord-010092-uftc8inx 9634 12 - - HYPH cord-010092-uftc8inx 9634 13 frame frame NN cord-010092-uftc8inx 9634 14 duplication duplication NN cord-010092-uftc8inx 9634 15 of of IN cord-010092-uftc8inx 9634 16 seven seven CD cord-010092-uftc8inx 9634 17 amino amino NN cord-010092-uftc8inx 9634 18 acids acid NNS cord-010092-uftc8inx 9634 19 after after IN cord-010092-uftc8inx 9634 20 codon codon NNP cord-010092-uftc8inx 9634 21 188 188 CD cord-010092-uftc8inx 9634 22 ( ( -LRB- cord-010092-uftc8inx 9634 23 p.dup_182_188QDVSMRR p.dup_182_188QDVSMRR NNP cord-010092-uftc8inx 9634 24 ) ) -RRB- cord-010092-uftc8inx 9634 25 , , , cord-010092-uftc8inx 9634 26 with with IN cord-010092-uftc8inx 9634 27 synonymous synonymous JJ cord-010092-uftc8inx 9634 28 change change NN cord-010092-uftc8inx 9634 29 of of IN cord-010092-uftc8inx 9634 30 the the DT cord-010092-uftc8inx 9634 31 repeated repeat VBN cord-010092-uftc8inx 9634 32 codon codon NN cord-010092-uftc8inx 9634 33 182 182 CD cord-010092-uftc8inx 9634 34 ( ( -LRB- cord-010092-uftc8inx 9634 35 CGC CGC NNP cord-010092-uftc8inx 9634 36 > > XX cord-010092-uftc8inx 9634 37 CGG CGG NNP cord-010092-uftc8inx 9634 38 ) ) -RRB- cord-010092-uftc8inx 9634 39 and and CC cord-010092-uftc8inx 9634 40 188 188 CD cord-010092-uftc8inx 9634 41 ( ( -LRB- cord-010092-uftc8inx 9634 42 CGG CGG NNP cord-010092-uftc8inx 9634 43 > > XX cord-010092-uftc8inx 9634 44 CGC CGC NNP cord-010092-uftc8inx 9634 45 ) ) -RRB- cord-010092-uftc8inx 9634 46 but but CC cord-010092-uftc8inx 9634 47 both both DT cord-010092-uftc8inx 9634 48 coding code VBG cord-010092-uftc8inx 9634 49 arginine arginine NN cord-010092-uftc8inx 9634 50 ( ( -LRB- cord-010092-uftc8inx 9634 51 R r NN cord-010092-uftc8inx 9634 52 ) ) -RRB- cord-010092-uftc8inx 9634 53 . . . cord-010092-uftc8inx 9635 1 Inheritance inheritance NN cord-010092-uftc8inx 9635 2 of of IN cord-010092-uftc8inx 9635 3 ABO*A ABO*A NNP cord-010092-uftc8inx 9635 4 c.dup543_563 c.dup543_563 CD cord-010092-uftc8inx 9635 5 allele allele NN cord-010092-uftc8inx 9635 6 was be VBD cord-010092-uftc8inx 9635 7 confirmed confirm VBN cord-010092-uftc8inx 9635 8 by by IN cord-010092-uftc8inx 9635 9 family family NN cord-010092-uftc8inx 9635 10 studies study NNS cord-010092-uftc8inx 9635 11 of of IN cord-010092-uftc8inx 9635 12 one one CD cord-010092-uftc8inx 9635 13 donor donor NN cord-010092-uftc8inx 9635 14 : : : cord-010092-uftc8inx 9635 15 his -PRON- PRP$ cord-010092-uftc8inx 9635 16 father father NN cord-010092-uftc8inx 9635 17 and and CC cord-010092-uftc8inx 9635 18 sister sister NN cord-010092-uftc8inx 9635 19 had have VBD cord-010092-uftc8inx 9635 20 A a DT cord-010092-uftc8inx 9635 21 / / SYM cord-010092-uftc8inx 9635 22 B b NN cord-010092-uftc8inx 9635 23 genotype genotype NN cord-010092-uftc8inx 9635 24 associated associate VBN cord-010092-uftc8inx 9635 25 with with IN cord-010092-uftc8inx 9635 26 normal normal JJ cord-010092-uftc8inx 9635 27 A a NN cord-010092-uftc8inx 9635 28 and and CC cord-010092-uftc8inx 9635 29 B b NN cord-010092-uftc8inx 9635 30 antigens antigen NNS cord-010092-uftc8inx 9635 31 expression expression NN cord-010092-uftc8inx 9635 32 ; ; : cord-010092-uftc8inx 9635 33 his -PRON- PRP$ cord-010092-uftc8inx 9635 34 mother mother NN cord-010092-uftc8inx 9635 35 had have VBD cord-010092-uftc8inx 9635 36 normal normal JJ cord-010092-uftc8inx 9635 37 A a DT cord-010092-uftc8inx 9635 38 antigen antigen NN cord-010092-uftc8inx 9635 39 expression expression NN cord-010092-uftc8inx 9635 40 . . . cord-010092-uftc8inx 9636 1 She -PRON- PRP cord-010092-uftc8inx 9636 2 carried carry VBD cord-010092-uftc8inx 9636 3 ABO*A1.01 abo*a1.01 JJ cord-010092-uftc8inx 9636 4 allele allele NN cord-010092-uftc8inx 9636 5 and and CC cord-010092-uftc8inx 9636 6 the the DT cord-010092-uftc8inx 9636 7 same same JJ cord-010092-uftc8inx 9636 8 ABO*A ABO*A NNP cord-010092-uftc8inx 9636 9 c.dup543_563 c.dup543_563 CD cord-010092-uftc8inx 9636 10 allele allele NN cord-010092-uftc8inx 9636 11 as as IN cord-010092-uftc8inx 9636 12 a a DT cord-010092-uftc8inx 9636 13 son son NN cord-010092-uftc8inx 9636 14 . . . cord-010092-uftc8inx 9637 1 Summary Summary NNP cord-010092-uftc8inx 9637 2 / / SYM cord-010092-uftc8inx 9637 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 9637 4 : : : cord-010092-uftc8inx 9638 1 A a DT cord-010092-uftc8inx 9638 2 novel novel NN cord-010092-uftc8inx 9639 1 A a DT cord-010092-uftc8inx 9639 2 weak weak JJ cord-010092-uftc8inx 9639 3 allele allele NN cord-010092-uftc8inx 9639 4 at at IN cord-010092-uftc8inx 9639 5 the the DT cord-010092-uftc8inx 9639 6 ABO ABO NNP cord-010092-uftc8inx 9639 7 gene gene NN cord-010092-uftc8inx 9639 8 detected detect VBD cord-010092-uftc8inx 9639 9 in in IN cord-010092-uftc8inx 9639 10 three three CD cord-010092-uftc8inx 9639 11 unrelated unrelated JJ cord-010092-uftc8inx 9639 12 Polish polish JJ cord-010092-uftc8inx 9639 13 individuals individual NNS cord-010092-uftc8inx 9639 14 is be VBZ cord-010092-uftc8inx 9639 15 an an DT cord-010092-uftc8inx 9639 16 in in IN cord-010092-uftc8inx 9639 17 - - HYPH cord-010092-uftc8inx 9639 18 frame frame NN cord-010092-uftc8inx 9639 19 insertion insertion NN cord-010092-uftc8inx 9639 20 of of IN cord-010092-uftc8inx 9639 21 seven seven CD cord-010092-uftc8inx 9639 22 amino amino NN cord-010092-uftc8inx 9639 23 acids acid NNS cord-010092-uftc8inx 9639 24 to to IN cord-010092-uftc8inx 9639 25 the the DT cord-010092-uftc8inx 9639 26 wild wild JJ cord-010092-uftc8inx 9639 27 - - HYPH cord-010092-uftc8inx 9639 28 type type NN cord-010092-uftc8inx 9639 29 glycosyltransferase glycosyltransferase NN cord-010092-uftc8inx 9640 1 A. A. NNP cord-010092-uftc8inx 9641 1 The the DT cord-010092-uftc8inx 9641 2 stability stability NN cord-010092-uftc8inx 9641 3 of of IN cord-010092-uftc8inx 9641 4 the the DT cord-010092-uftc8inx 9641 5 encoded encode VBN cord-010092-uftc8inx 9641 6 protein protein NN cord-010092-uftc8inx 9641 7 may may MD cord-010092-uftc8inx 9641 8 be be VB cord-010092-uftc8inx 9641 9 affected affect VBN cord-010092-uftc8inx 9641 10 causing cause VBG cord-010092-uftc8inx 9641 11 the the DT cord-010092-uftc8inx 9641 12 weak weak JJ cord-010092-uftc8inx 9641 13 A a DT cord-010092-uftc8inx 9641 14 phenotype phenotype NN cord-010092-uftc8inx 9641 15 . . . cord-010092-uftc8inx 9642 1 The the DT cord-010092-uftc8inx 9642 2 inheritance inheritance NN cord-010092-uftc8inx 9642 3 of of IN cord-010092-uftc8inx 9642 4 this this DT cord-010092-uftc8inx 9642 5 mutation mutation NN cord-010092-uftc8inx 9642 6 was be VBD cord-010092-uftc8inx 9642 7 confirmed confirm VBN cord-010092-uftc8inx 9642 8 in in IN cord-010092-uftc8inx 9642 9 the the DT cord-010092-uftc8inx 9642 10 family family NN cord-010092-uftc8inx 9642 11 studies study NNS cord-010092-uftc8inx 9642 12 . . . cord-010092-uftc8inx 9643 1 Background background NN cord-010092-uftc8inx 9643 2 : : : cord-010092-uftc8inx 9644 1 Since since IN cord-010092-uftc8inx 9644 2 the the DT cord-010092-uftc8inx 9644 3 cloning cloning NN cord-010092-uftc8inx 9644 4 in in IN cord-010092-uftc8inx 9644 5 1990 1990 CD cord-010092-uftc8inx 9644 6 of of IN cord-010092-uftc8inx 9644 7 cDNA cdna NN cord-010092-uftc8inx 9644 8 corresponding correspond VBG cord-010092-uftc8inx 9644 9 to to IN cord-010092-uftc8inx 9644 10 mRNA mRNA NNP cord-010092-uftc8inx 9644 11 transcribed transcribe VBN cord-010092-uftc8inx 9644 12 at at IN cord-010092-uftc8inx 9644 13 the the DT cord-010092-uftc8inx 9644 14 blood blood NN cord-010092-uftc8inx 9644 15 group group NN cord-010092-uftc8inx 9644 16 ABO ABO NNP cord-010092-uftc8inx 9644 17 locus locus NN cord-010092-uftc8inx 9644 18 , , , cord-010092-uftc8inx 9644 19 polymorphisms polymorphism NNS cord-010092-uftc8inx 9644 20 and and CC cord-010092-uftc8inx 9644 21 phenotype phenotype NN cord-010092-uftc8inx 9644 22 - - HYPH cord-010092-uftc8inx 9644 23 genotype genotype NN cord-010092-uftc8inx 9644 24 correlations correlation NNS cord-010092-uftc8inx 9644 25 have have VBP cord-010092-uftc8inx 9644 26 been be VBN cord-010092-uftc8inx 9644 27 reported report VBN cord-010092-uftc8inx 9644 28 by by IN cord-010092-uftc8inx 9644 29 many many JJ cord-010092-uftc8inx 9644 30 investigators investigator NNS cord-010092-uftc8inx 9644 31 . . . cord-010092-uftc8inx 9645 1 Although although IN cord-010092-uftc8inx 9645 2 many many JJ cord-010092-uftc8inx 9645 3 subgroups subgroup NNS cord-010092-uftc8inx 9645 4 have have VBP cord-010092-uftc8inx 9645 5 been be VBN cord-010092-uftc8inx 9645 6 explained explain VBN cord-010092-uftc8inx 9645 7 at at IN cord-010092-uftc8inx 9645 8 the the DT cord-010092-uftc8inx 9645 9 genetic genetic JJ cord-010092-uftc8inx 9645 10 level level NN cord-010092-uftc8inx 9645 11 , , , cord-010092-uftc8inx 9645 12 unresolved unresolved JJ cord-010092-uftc8inx 9645 13 samples sample NNS cord-010092-uftc8inx 9645 14 are be VBP cord-010092-uftc8inx 9645 15 still still RB cord-010092-uftc8inx 9645 16 encountered encounter VBN cord-010092-uftc8inx 9645 17 in in IN cord-010092-uftc8inx 9645 18 clinical clinical JJ cord-010092-uftc8inx 9645 19 practice practice NN cord-010092-uftc8inx 9645 20 . . . cord-010092-uftc8inx 9646 1 We -PRON- PRP cord-010092-uftc8inx 9646 2 report report VBP cord-010092-uftc8inx 9646 3 here here RB cord-010092-uftc8inx 9646 4 the the DT cord-010092-uftc8inx 9646 5 result result NN cord-010092-uftc8inx 9646 6 of of IN cord-010092-uftc8inx 9646 7 an an DT cord-010092-uftc8inx 9646 8 ABO ABO NNP cord-010092-uftc8inx 9646 9 investigation investigation NN cord-010092-uftc8inx 9646 10 of of IN cord-010092-uftc8inx 9646 11 a a DT cord-010092-uftc8inx 9646 12 sample sample NN cord-010092-uftc8inx 9646 13 from from IN cord-010092-uftc8inx 9646 14 a a DT cord-010092-uftc8inx 9646 15 Swedish swedish JJ cord-010092-uftc8inx 9646 16 blood blood NN cord-010092-uftc8inx 9646 17 donor donor NN cord-010092-uftc8inx 9646 18 that that WDT cord-010092-uftc8inx 9646 19 showed show VBD cord-010092-uftc8inx 9646 20 a a DT cord-010092-uftc8inx 9646 21 very very RB cord-010092-uftc8inx 9646 22 weak weak JJ cord-010092-uftc8inx 9646 23 agglutination agglutination NN cord-010092-uftc8inx 9646 24 of of IN cord-010092-uftc8inx 9646 25 RBCs rbc NNS cord-010092-uftc8inx 9646 26 with with IN cord-010092-uftc8inx 9646 27 anti anti JJ cord-010092-uftc8inx 9646 28 - - JJ cord-010092-uftc8inx 9646 29 A a NN cord-010092-uftc8inx 9646 30 in in IN cord-010092-uftc8inx 9646 31 routine routine JJ cord-010092-uftc8inx 9646 32 forward forward NN cord-010092-uftc8inx 9646 33 typing typing NN cord-010092-uftc8inx 9646 34 . . . cord-010092-uftc8inx 9647 1 Aims aim VBZ cord-010092-uftc8inx 9647 2 : : : cord-010092-uftc8inx 9647 3 To to TO cord-010092-uftc8inx 9647 4 elucidate elucidate VB cord-010092-uftc8inx 9647 5 the the DT cord-010092-uftc8inx 9647 6 genetic genetic JJ cord-010092-uftc8inx 9647 7 basis basis NN cord-010092-uftc8inx 9647 8 of of IN cord-010092-uftc8inx 9647 9 the the DT cord-010092-uftc8inx 9647 10 apparent apparent JJ cord-010092-uftc8inx 9647 11 weak weak JJ cord-010092-uftc8inx 9647 12 A a DT cord-010092-uftc8inx 9647 13 subgroup subgroup NN cord-010092-uftc8inx 9647 14 . . . cord-010092-uftc8inx 9648 1 Methods method NNS cord-010092-uftc8inx 9648 2 : : : cord-010092-uftc8inx 9648 3 Routine routine JJ cord-010092-uftc8inx 9648 4 ABO ABO NNP cord-010092-uftc8inx 9648 5 genotyping genotyping NN cord-010092-uftc8inx 9648 6 by by IN cord-010092-uftc8inx 9648 7 PCR PCR NNP cord-010092-uftc8inx 9648 8 - - HYPH cord-010092-uftc8inx 9648 9 ASP ASP NNP cord-010092-uftc8inx 9648 10 and and CC cord-010092-uftc8inx 9648 11 PCR PCR NNP cord-010092-uftc8inx 9648 12 - - HYPH cord-010092-uftc8inx 9648 13 RFLP RFLP NNP cord-010092-uftc8inx 9648 14 including include VBG cord-010092-uftc8inx 9648 15 PCRbased pcrbase VBN cord-010092-uftc8inx 9648 16 analysis analysis NN cord-010092-uftc8inx 9648 17 of of IN cord-010092-uftc8inx 9648 18 the the DT cord-010092-uftc8inx 9648 19 upstream upstream JJ cord-010092-uftc8inx 9648 20 CBF CBF NNP cord-010092-uftc8inx 9648 21 / / SYM cord-010092-uftc8inx 9648 22 NF NF NNP cord-010092-uftc8inx 9648 23 - - HYPH cord-010092-uftc8inx 9648 24 Y Y NNP cord-010092-uftc8inx 9648 25 - - HYPH cord-010092-uftc8inx 9648 26 binding bind VBG cord-010092-uftc8inx 9648 27 enhancer enhancer NN cord-010092-uftc8inx 9648 28 region region NN cord-010092-uftc8inx 9648 29 was be VBD cord-010092-uftc8inx 9648 30 carried carry VBN cord-010092-uftc8inx 9648 31 out out RP cord-010092-uftc8inx 9648 32 . . . cord-010092-uftc8inx 9649 1 Further further JJ cord-010092-uftc8inx 9649 2 genetic genetic JJ cord-010092-uftc8inx 9649 3 analysis analysis NN cord-010092-uftc8inx 9649 4 was be VBD cord-010092-uftc8inx 9649 5 performed perform VBN cord-010092-uftc8inx 9649 6 by by IN cord-010092-uftc8inx 9649 7 DNA dna NN cord-010092-uftc8inx 9649 8 sequencing sequencing NN cord-010092-uftc8inx 9649 9 of of IN cord-010092-uftc8inx 9649 10 ABO ABO NNP cord-010092-uftc8inx 9649 11 exons exon NNS cord-010092-uftc8inx 9649 12 1 1 CD cord-010092-uftc8inx 9649 13 - - SYM cord-010092-uftc8inx 9649 14 7 7 CD cord-010092-uftc8inx 9649 15 ( ( -LRB- cord-010092-uftc8inx 9649 16 including include VBG cord-010092-uftc8inx 9649 17 50 50 CD cord-010092-uftc8inx 9649 18 base base NN cord-010092-uftc8inx 9649 19 pairs pair NNS cord-010092-uftc8inx 9649 20 of of IN cord-010092-uftc8inx 9649 21 the the DT cord-010092-uftc8inx 9649 22 adjacent adjacent JJ cord-010092-uftc8inx 9649 23 introns intron NNS cord-010092-uftc8inx 9649 24 ) ) -RRB- cord-010092-uftc8inx 9649 25 and and CC cord-010092-uftc8inx 9649 26 the the DT cord-010092-uftc8inx 9649 27 proximal proximal JJ cord-010092-uftc8inx 9649 28 promoter promoter NN cord-010092-uftc8inx 9649 29 . . . cord-010092-uftc8inx 9650 1 Flow flow VB cord-010092-uftc8inx 9650 2 cytometric cytometric JJ cord-010092-uftc8inx 9650 3 testing testing NN cord-010092-uftc8inx 9650 4 of of IN cord-010092-uftc8inx 9650 5 RBCs rbc NNS cord-010092-uftc8inx 9650 6 was be VBD cord-010092-uftc8inx 9650 7 performed perform VBN cord-010092-uftc8inx 9650 8 with with IN cord-010092-uftc8inx 9650 9 monoclonal monoclonal JJ cord-010092-uftc8inx 9650 10 anti anti NNP cord-010092-uftc8inx 9650 11 - - NNP cord-010092-uftc8inx 9650 12 A a JJ cord-010092-uftc8inx 9650 13 , , , cord-010092-uftc8inx 9650 14 anti anti NN cord-010092-uftc8inx 9650 15 - - NN cord-010092-uftc8inx 9650 16 B b JJ cord-010092-uftc8inx 9650 17 and and CC cord-010092-uftc8inx 9650 18 anti anti JJ cord-010092-uftc8inx 9650 19 - - JJ cord-010092-uftc8inx 9650 20 H. h. JJ cord-010092-uftc8inx 9650 21 Results result NNS cord-010092-uftc8inx 9650 22 : : : cord-010092-uftc8inx 9651 1 The the DT cord-010092-uftc8inx 9651 2 weak weak JJ cord-010092-uftc8inx 9651 3 agglutination agglutination NN cord-010092-uftc8inx 9651 4 of of IN cord-010092-uftc8inx 9651 5 erythrocytes erythrocyte NNS cord-010092-uftc8inx 9651 6 with with IN cord-010092-uftc8inx 9651 7 anti anti JJ cord-010092-uftc8inx 9651 8 - - JJ cord-010092-uftc8inx 9651 9 A a NN cord-010092-uftc8inx 9651 10 was be VBD cord-010092-uftc8inx 9651 11 accompanied accompany VBN cord-010092-uftc8inx 9651 12 by by IN cord-010092-uftc8inx 9651 13 the the DT cord-010092-uftc8inx 9651 14 expected expect VBN cord-010092-uftc8inx 9651 15 lack lack NN cord-010092-uftc8inx 9651 16 of of IN cord-010092-uftc8inx 9651 17 anti anti JJ cord-010092-uftc8inx 9651 18 - - JJ cord-010092-uftc8inx 9651 19 A a JJ cord-010092-uftc8inx 9651 20 and and CC cord-010092-uftc8inx 9651 21 anti anti JJ cord-010092-uftc8inx 9651 22 - - JJ cord-010092-uftc8inx 9651 23 A1 a1 NN cord-010092-uftc8inx 9651 24 in in IN cord-010092-uftc8inx 9651 25 plasma plasma NN cord-010092-uftc8inx 9651 26 . . . cord-010092-uftc8inx 9652 1 ABO ABO NNP cord-010092-uftc8inx 9652 2 genotyping genotyping NN cord-010092-uftc8inx 9652 3 gave give VBD cord-010092-uftc8inx 9652 4 the the DT cord-010092-uftc8inx 9652 5 genotype genotype NN cord-010092-uftc8inx 9652 6 ABO*A1.01 ABO*A1.01 . cord-010092-uftc8inx 9653 1 /O2.01 /O2.01 NFP cord-010092-uftc8inx 9653 2 usually usually RB cord-010092-uftc8inx 9653 3 consistent consistent JJ cord-010092-uftc8inx 9653 4 with with IN cord-010092-uftc8inx 9653 5 normal normal JJ cord-010092-uftc8inx 9653 6 expression expression NN cord-010092-uftc8inx 9653 7 of of IN cord-010092-uftc8inx 9653 8 A a DT cord-010092-uftc8inx 9653 9 antigen antigen NN cord-010092-uftc8inx 9653 10 . . . cord-010092-uftc8inx 9654 1 Enhancer enhancer NN cord-010092-uftc8inx 9654 2 analysis analysis NN cord-010092-uftc8inx 9654 3 resulted result VBD cord-010092-uftc8inx 9654 4 in in IN cord-010092-uftc8inx 9654 5 an an DT cord-010092-uftc8inx 9654 6 amplification amplification NN cord-010092-uftc8inx 9654 7 product product NN cord-010092-uftc8inx 9654 8 corresponding correspond VBG cord-010092-uftc8inx 9654 9 to to IN cord-010092-uftc8inx 9654 10 the the DT cord-010092-uftc8inx 9654 11 expected expect VBN cord-010092-uftc8inx 9654 12 single single JJ cord-010092-uftc8inx 9654 13 CBF CBF NNP cord-010092-uftc8inx 9654 14 / / SYM cord-010092-uftc8inx 9654 15 NF NF NNP cord-010092-uftc8inx 9654 16 - - HYPH cord-010092-uftc8inx 9654 17 Y Y NNP cord-010092-uftc8inx 9654 18 binding binding NN cord-010092-uftc8inx 9654 19 motif motif NN cord-010092-uftc8inx 9654 20 . . . cord-010092-uftc8inx 9655 1 Flow flow VB cord-010092-uftc8inx 9655 2 cytometric cytometric JJ cord-010092-uftc8inx 9655 3 testing testing NN cord-010092-uftc8inx 9655 4 of of IN cord-010092-uftc8inx 9655 5 the the DT cord-010092-uftc8inx 9655 6 sample sample NN cord-010092-uftc8inx 9655 7 showed show VBD cord-010092-uftc8inx 9655 8 A a DT cord-010092-uftc8inx 9655 9 antigen antigen NN cord-010092-uftc8inx 9655 10 expression expression NN cord-010092-uftc8inx 9655 11 with with IN cord-010092-uftc8inx 9655 12 an an DT cord-010092-uftc8inx 9655 13 almost almost RB cord-010092-uftc8inx 9655 14 chimeric chimeric JJ cord-010092-uftc8inx 9655 15 pattern pattern NN cord-010092-uftc8inx 9655 16 where where WRB cord-010092-uftc8inx 9655 17 the the DT cord-010092-uftc8inx 9655 18 majority majority NN cord-010092-uftc8inx 9655 19 of of IN cord-010092-uftc8inx 9655 20 the the DT cord-010092-uftc8inx 9655 21 cells cell NNS cord-010092-uftc8inx 9655 22 ( ( -LRB- cord-010092-uftc8inx 9655 23 approximately approximately RB cord-010092-uftc8inx 9655 24 85 85 CD cord-010092-uftc8inx 9655 25 % % NN cord-010092-uftc8inx 9655 26 ) ) -RRB- cord-010092-uftc8inx 9655 27 expressed express VBD cord-010092-uftc8inx 9655 28 the the DT cord-010092-uftc8inx 9655 29 A a DT cord-010092-uftc8inx 9655 30 antigen antigen NN cord-010092-uftc8inx 9655 31 at at IN cord-010092-uftc8inx 9655 32 a a DT cord-010092-uftc8inx 9655 33 very very RB cord-010092-uftc8inx 9655 34 low low JJ cord-010092-uftc8inx 9655 35 level level NN cord-010092-uftc8inx 9655 36 , , , cord-010092-uftc8inx 9655 37 marginally marginally RB cord-010092-uftc8inx 9655 38 distinguishable distinguishable JJ cord-010092-uftc8inx 9655 39 from from IN cord-010092-uftc8inx 9655 40 the the DT cord-010092-uftc8inx 9655 41 group group NN cord-010092-uftc8inx 9655 42 O o UH cord-010092-uftc8inx 9655 43 control control NN cord-010092-uftc8inx 9655 44 . . . cord-010092-uftc8inx 9656 1 The the DT cord-010092-uftc8inx 9656 2 remaining remain VBG cord-010092-uftc8inx 9656 3 approximately approximately RB cord-010092-uftc8inx 9656 4 15 15 CD cord-010092-uftc8inx 9656 5 % % NN cord-010092-uftc8inx 9656 6 of of IN cord-010092-uftc8inx 9656 7 the the DT cord-010092-uftc8inx 9656 8 cells cell NNS cord-010092-uftc8inx 9656 9 displayed display VBD cord-010092-uftc8inx 9656 10 an an DT cord-010092-uftc8inx 9656 11 A a DT cord-010092-uftc8inx 9656 12 antigen antigen NN cord-010092-uftc8inx 9656 13 level level NN cord-010092-uftc8inx 9656 14 ranging range VBG cord-010092-uftc8inx 9656 15 from from IN cord-010092-uftc8inx 9656 16 normal normal JJ cord-010092-uftc8inx 9656 17 to to IN cord-010092-uftc8inx 9656 18 very very RB cord-010092-uftc8inx 9656 19 weak weak JJ cord-010092-uftc8inx 9656 20 . . . cord-010092-uftc8inx 9657 1 Genomic genomic JJ cord-010092-uftc8inx 9657 2 ABO ABO NNP cord-010092-uftc8inx 9657 3 sequencing sequencing NN cord-010092-uftc8inx 9657 4 showed show VBD cord-010092-uftc8inx 9657 5 an an DT cord-010092-uftc8inx 9657 6 ABO*A1.01-like abo*a1.01-like JJ cord-010092-uftc8inx 9657 7 allele allele NN cord-010092-uftc8inx 9657 8 except except IN cord-010092-uftc8inx 9657 9 for for IN cord-010092-uftc8inx 9657 10 a a DT cord-010092-uftc8inx 9657 11 novel novel JJ cord-010092-uftc8inx 9657 12 mutation mutation NN cord-010092-uftc8inx 9657 13 located locate VBN cord-010092-uftc8inx 9657 14 in in IN cord-010092-uftc8inx 9657 15 intron intron NNP cord-010092-uftc8inx 9657 16 5 5 CD cord-010092-uftc8inx 9657 17 , , , cord-010092-uftc8inx 9657 18 c.239 c.239 NNP cord-010092-uftc8inx 9657 19 + + CC cord-010092-uftc8inx 9657 20 4G. 4g. CD cord-010092-uftc8inx 9658 1 The the DT cord-010092-uftc8inx 9658 2 O o NN cord-010092-uftc8inx 9658 3 2 2 CD cord-010092-uftc8inx 9658 4 allele allele NN cord-010092-uftc8inx 9658 5 had have VBD cord-010092-uftc8inx 9658 6 an an DT cord-010092-uftc8inx 9658 7 additional additional JJ cord-010092-uftc8inx 9658 8 SNP SNP NNP cord-010092-uftc8inx 9658 9 , , , cord-010092-uftc8inx 9658 10 c.689 c.689 NN cord-010092-uftc8inx 9658 11 G g NN cord-010092-uftc8inx 9659 1 > > XX cord-010092-uftc8inx 9660 1 A a DT cord-010092-uftc8inx 9660 2 , , , cord-010092-uftc8inx 9660 3 consistent consistent JJ cord-010092-uftc8inx 9660 4 with with IN cord-010092-uftc8inx 9660 5 the the DT cord-010092-uftc8inx 9660 6 ABO*O2.03 abo*o2.03 CD cord-010092-uftc8inx 9660 7 allele allele NN cord-010092-uftc8inx 9660 8 variant variant NN cord-010092-uftc8inx 9660 9 Summary Summary NNP cord-010092-uftc8inx 9660 10 / / SYM cord-010092-uftc8inx 9660 11 Conclusions Conclusions NNPS cord-010092-uftc8inx 9660 12 : : : cord-010092-uftc8inx 9661 1 A a DT cord-010092-uftc8inx 9661 2 previously previously RB cord-010092-uftc8inx 9661 3 unreported unreported JJ cord-010092-uftc8inx 9661 4 variant variant NN cord-010092-uftc8inx 9661 5 , , , cord-010092-uftc8inx 9661 6 c.239 c.239 NNP cord-010092-uftc8inx 9661 7 + + SYM cord-010092-uftc8inx 9661 8 4A 4a NN cord-010092-uftc8inx 9661 9 > > XX cord-010092-uftc8inx 9661 10 G g NN cord-010092-uftc8inx 9661 11 , , , cord-010092-uftc8inx 9661 12 likely likely RB cord-010092-uftc8inx 9661 13 effecting effect VBG cord-010092-uftc8inx 9661 14 the the DT cord-010092-uftc8inx 9661 15 5 5 CD cord-010092-uftc8inx 9661 16 0 0 CD cord-010092-uftc8inx 9661 17 -donor -donor NN cord-010092-uftc8inx 9661 18 splice splice NN cord-010092-uftc8inx 9661 19 site site NN cord-010092-uftc8inx 9661 20 of of IN cord-010092-uftc8inx 9661 21 intron intron NN cord-010092-uftc8inx 9661 22 5 5 CD cord-010092-uftc8inx 9661 23 was be VBD cord-010092-uftc8inx 9661 24 found find VBN cord-010092-uftc8inx 9661 25 in in IN cord-010092-uftc8inx 9661 26 an an DT cord-010092-uftc8inx 9661 27 A a DT cord-010092-uftc8inx 9661 28 weak weak JJ cord-010092-uftc8inx 9661 29 sample sample NN cord-010092-uftc8inx 9661 30 . . . cord-010092-uftc8inx 9662 1 This this DT cord-010092-uftc8inx 9662 2 type type NN cord-010092-uftc8inx 9662 3 of of IN cord-010092-uftc8inx 9662 4 mutations mutation NNS cord-010092-uftc8inx 9662 5 is be VBZ cord-010092-uftc8inx 9662 6 expected expect VBN cord-010092-uftc8inx 9662 7 to to TO cord-010092-uftc8inx 9662 8 decrease decrease VB cord-010092-uftc8inx 9662 9 mRNA mrna NN cord-010092-uftc8inx 9662 10 stability stability NN cord-010092-uftc8inx 9662 11 and/or and/or CC cord-010092-uftc8inx 9662 12 cause cause VB cord-010092-uftc8inx 9662 13 skipping skip VBG cord-010092-uftc8inx 9662 14 of of IN cord-010092-uftc8inx 9662 15 the the DT cord-010092-uftc8inx 9662 16 preceding precede VBG cord-010092-uftc8inx 9662 17 exon exon NN cord-010092-uftc8inx 9662 18 in in IN cord-010092-uftc8inx 9662 19 the the DT cord-010092-uftc8inx 9662 20 mRNA mrna NN cord-010092-uftc8inx 9662 21 . . . cord-010092-uftc8inx 9663 1 However however RB cord-010092-uftc8inx 9663 2 , , , cord-010092-uftc8inx 9663 3 small small JJ cord-010092-uftc8inx 9663 4 amounts amount NNS cord-010092-uftc8inx 9663 5 of of IN cord-010092-uftc8inx 9663 6 full full JJ cord-010092-uftc8inx 9663 7 - - HYPH cord-010092-uftc8inx 9663 8 length length NN cord-010092-uftc8inx 9663 9 enzyme enzyme NN cord-010092-uftc8inx 9663 10 might may MD cord-010092-uftc8inx 9663 11 still still RB cord-010092-uftc8inx 9663 12 be be VB cord-010092-uftc8inx 9663 13 made make VBN cord-010092-uftc8inx 9663 14 , , , cord-010092-uftc8inx 9663 15 being be VBG cord-010092-uftc8inx 9663 16 able able JJ cord-010092-uftc8inx 9663 17 to to TO cord-010092-uftc8inx 9663 18 give give VB cord-010092-uftc8inx 9663 19 rise rise NN cord-010092-uftc8inx 9663 20 to to IN cord-010092-uftc8inx 9663 21 the the DT cord-010092-uftc8inx 9663 22 weak weak JJ cord-010092-uftc8inx 9663 23 A a DT cord-010092-uftc8inx 9663 24 antigen antigen NN cord-010092-uftc8inx 9663 25 expression expression NN cord-010092-uftc8inx 9663 26 seen see VBN cord-010092-uftc8inx 9663 27 in in IN cord-010092-uftc8inx 9663 28 this this DT cord-010092-uftc8inx 9663 29 individual individual NN cord-010092-uftc8inx 9663 30 . . . cord-010092-uftc8inx 9664 1 Interestingly interestingly RB cord-010092-uftc8inx 9664 2 , , , cord-010092-uftc8inx 9664 3 this this DT cord-010092-uftc8inx 9664 4 mutation mutation NN cord-010092-uftc8inx 9664 5 is be VBZ cord-010092-uftc8inx 9664 6 very very RB cord-010092-uftc8inx 9664 7 similar similar JJ cord-010092-uftc8inx 9664 8 to to IN cord-010092-uftc8inx 9664 9 the the DT cord-010092-uftc8inx 9664 10 genetic genetic JJ cord-010092-uftc8inx 9664 11 variant variant NN cord-010092-uftc8inx 9664 12 underlying underlie VBG cord-010092-uftc8inx 9664 13 the the DT cord-010092-uftc8inx 9664 14 weak weak JJ cord-010092-uftc8inx 9664 15 A A NNP cord-010092-uftc8inx 9664 16 subgroup subgroup NN cord-010092-uftc8inx 9664 17 A a DT cord-010092-uftc8inx 9664 18 finn finn NN cord-010092-uftc8inx 9664 19 . . . cord-010092-uftc8inx 9665 1 In in IN cord-010092-uftc8inx 9665 2 this this DT cord-010092-uftc8inx 9665 3 case case NN cord-010092-uftc8inx 9665 4 , , , cord-010092-uftc8inx 9665 5 however however RB cord-010092-uftc8inx 9665 6 , , , cord-010092-uftc8inx 9665 7 the the DT cord-010092-uftc8inx 9665 8 c. c. NN cord-010092-uftc8inx 9665 9 374 374 CD cord-010092-uftc8inx 9666 1 +4A +4A NNP cord-010092-uftc8inx 9666 2 > > XX cord-010092-uftc8inx 9667 1 G g NN cord-010092-uftc8inx 9667 2 mutation mutation NN cord-010092-uftc8inx 9667 3 is be VBZ cord-010092-uftc8inx 9667 4 located locate VBN cord-010092-uftc8inx 9667 5 in in IN cord-010092-uftc8inx 9667 6 the the DT cord-010092-uftc8inx 9667 7 5 5 CD cord-010092-uftc8inx 9667 8 0 0 CD cord-010092-uftc8inx 9667 9 -end -end : cord-010092-uftc8inx 9667 10 of of IN cord-010092-uftc8inx 9667 11 intron intron NN cord-010092-uftc8inx 9667 12 6 6 CD cord-010092-uftc8inx 9667 13 and and CC cord-010092-uftc8inx 9667 14 is be VBZ cord-010092-uftc8inx 9667 15 predicted predict VBN cord-010092-uftc8inx 9667 16 to to TO cord-010092-uftc8inx 9667 17 cause cause VB cord-010092-uftc8inx 9667 18 partial partial JJ cord-010092-uftc8inx 9667 19 skipping skipping NN cord-010092-uftc8inx 9667 20 of of IN cord-010092-uftc8inx 9667 21 exon exon NN cord-010092-uftc8inx 9667 22 6 6 CD cord-010092-uftc8inx 9667 23 . . . cord-010092-uftc8inx 9668 1 Strikingly strikingly RB cord-010092-uftc8inx 9668 2 , , , cord-010092-uftc8inx 9668 3 the the DT cord-010092-uftc8inx 9668 4 A A NNP cord-010092-uftc8inx 9668 5 finn finn NNP cord-010092-uftc8inx 9668 6 phenotype phenotype NN cord-010092-uftc8inx 9668 7 also also RB cord-010092-uftc8inx 9668 8 results result VBZ cord-010092-uftc8inx 9668 9 in in IN cord-010092-uftc8inx 9668 10 a a DT cord-010092-uftc8inx 9668 11 pseudochimeric pseudochimeric JJ cord-010092-uftc8inx 9668 12 pattern pattern NN cord-010092-uftc8inx 9668 13 by by IN cord-010092-uftc8inx 9668 14 flow flow NN cord-010092-uftc8inx 9668 15 cytometry cytometry NN cord-010092-uftc8inx 9668 16 but but CC cord-010092-uftc8inx 9668 17 with with IN cord-010092-uftc8inx 9668 18 only only RB cord-010092-uftc8inx 9668 19 approximately approximately RB cord-010092-uftc8inx 9668 20 2 2 CD cord-010092-uftc8inx 9668 21 % % NN cord-010092-uftc8inx 9668 22 positively positively RB cord-010092-uftc8inx 9668 23 staining stain VBG cord-010092-uftc8inx 9668 24 erythrocytes erythrocyte NNS cord-010092-uftc8inx 9668 25 . . . cord-010092-uftc8inx 9669 1 Due due IN cord-010092-uftc8inx 9669 2 to to IN cord-010092-uftc8inx 9669 3 the the DT cord-010092-uftc8inx 9669 4 well well RB cord-010092-uftc8inx 9669 5 documented document VBN cord-010092-uftc8inx 9669 6 lack lack NN cord-010092-uftc8inx 9669 7 of of IN cord-010092-uftc8inx 9669 8 A a DT cord-010092-uftc8inx 9669 9 - - HYPH cord-010092-uftc8inx 9669 10 allele allele NN cord-010092-uftc8inx 9669 11 - - HYPH cord-010092-uftc8inx 9669 12 derived derive VBN cord-010092-uftc8inx 9669 13 mRNA mrna NN cord-010092-uftc8inx 9669 14 in in IN cord-010092-uftc8inx 9669 15 peripheral peripheral JJ cord-010092-uftc8inx 9669 16 blood blood NN cord-010092-uftc8inx 9669 17 , , , cord-010092-uftc8inx 9669 18 further further RB cord-010092-uftc8inx 9669 19 transcript transcript NN cord-010092-uftc8inx 9669 20 studies study NNS cord-010092-uftc8inx 9669 21 could could MD cord-010092-uftc8inx 9669 22 not not RB cord-010092-uftc8inx 9669 23 be be VB cord-010092-uftc8inx 9669 24 undertaken undertake VBN cord-010092-uftc8inx 9669 25 . . . cord-010092-uftc8inx 9670 1 Further further JJ cord-010092-uftc8inx 9670 2 studies study NNS cord-010092-uftc8inx 9670 3 are be VBP cord-010092-uftc8inx 9670 4 needed need VBN cord-010092-uftc8inx 9670 5 to to TO cord-010092-uftc8inx 9670 6 investigate investigate VB cord-010092-uftc8inx 9670 7 the the DT cord-010092-uftc8inx 9670 8 exact exact JJ cord-010092-uftc8inx 9670 9 mechanisms mechanism NNS cord-010092-uftc8inx 9670 10 underlying underlie VBG cord-010092-uftc8inx 9670 11 the the DT cord-010092-uftc8inx 9670 12 pseudochimeric pseudochimeric JJ cord-010092-uftc8inx 9670 13 pattern pattern NN cord-010092-uftc8inx 9670 14 observed observe VBN cord-010092-uftc8inx 9670 15 by by IN cord-010092-uftc8inx 9670 16 flow flow NN cord-010092-uftc8inx 9670 17 cytometry cytometry NN cord-010092-uftc8inx 9670 18 in in IN cord-010092-uftc8inx 9670 19 these these DT cord-010092-uftc8inx 9670 20 two two CD cord-010092-uftc8inx 9670 21 interesting interesting JJ cord-010092-uftc8inx 9670 22 genotypes genotype NNS cord-010092-uftc8inx 9670 23 / / SYM cord-010092-uftc8inx 9670 24 phenotypes phenotype NNS cord-010092-uftc8inx 9670 25 Abstract Abstract NNP cord-010092-uftc8inx 9670 26 withdrawn withdraw VBN cord-010092-uftc8inx 9670 27 . . . cord-010092-uftc8inx 9671 1 Background background NN cord-010092-uftc8inx 9671 2 : : : cord-010092-uftc8inx 9672 1 ABO ABO NNP cord-010092-uftc8inx 9672 2 is be VBZ cord-010092-uftc8inx 9672 3 the the DT cord-010092-uftc8inx 9672 4 clinically clinically RB cord-010092-uftc8inx 9672 5 most most RBS cord-010092-uftc8inx 9672 6 relevant relevant JJ cord-010092-uftc8inx 9672 7 blood blood NN cord-010092-uftc8inx 9672 8 group group NN cord-010092-uftc8inx 9672 9 system system NN cord-010092-uftc8inx 9672 10 in in IN cord-010092-uftc8inx 9672 11 transfusion transfusion NN cord-010092-uftc8inx 9672 12 and and CC cord-010092-uftc8inx 9672 13 transplantation transplantation NN cord-010092-uftc8inx 9672 14 medicine medicine NN cord-010092-uftc8inx 9672 15 . . . cord-010092-uftc8inx 9673 1 ABO ABO NNP cord-010092-uftc8inx 9673 2 genotyping genotyping NN cord-010092-uftc8inx 9673 3 is be VBZ cord-010092-uftc8inx 9673 4 potentially potentially RB cord-010092-uftc8inx 9673 5 useful useful JJ cord-010092-uftc8inx 9673 6 in in IN cord-010092-uftc8inx 9673 7 clarifying clarify VBG cord-010092-uftc8inx 9673 8 serologic serologic JJ cord-010092-uftc8inx 9673 9 blood blood NN cord-010092-uftc8inx 9673 10 grouping grouping NN cord-010092-uftc8inx 9673 11 discrepancies discrepancy NNS cord-010092-uftc8inx 9673 12 . . . cord-010092-uftc8inx 9674 1 This this DT cord-010092-uftc8inx 9674 2 scenario scenario NN cord-010092-uftc8inx 9674 3 includes include VBZ cord-010092-uftc8inx 9674 4 inherited inherit VBN cord-010092-uftc8inx 9674 5 subgroups subgroup NNS cord-010092-uftc8inx 9674 6 alleles allele NNS cord-010092-uftc8inx 9674 7 , , , cord-010092-uftc8inx 9674 8 temporary temporary JJ cord-010092-uftc8inx 9674 9 acquired acquire VBN cord-010092-uftc8inx 9674 10 variant variant NN cord-010092-uftc8inx 9674 11 ABO ABO NNP cord-010092-uftc8inx 9674 12 phenotypes phenotype NNS cord-010092-uftc8inx 9674 13 in in IN cord-010092-uftc8inx 9674 14 disease disease NN cord-010092-uftc8inx 9674 15 or or CC cord-010092-uftc8inx 9674 16 pregnancy pregnancy NN cord-010092-uftc8inx 9674 17 , , , cord-010092-uftc8inx 9674 18 and and CC cord-010092-uftc8inx 9674 19 chimerism chimerism NN cord-010092-uftc8inx 9674 20 due due IN cord-010092-uftc8inx 9674 21 to to IN cord-010092-uftc8inx 9674 22 exchange exchange NN cord-010092-uftc8inx 9674 23 of of IN cord-010092-uftc8inx 9674 24 progenitor progenitor NN cord-010092-uftc8inx 9674 25 cells cell NNS cord-010092-uftc8inx 9674 26 early early RB cord-010092-uftc8inx 9674 27 in in IN cord-010092-uftc8inx 9674 28 fetal fetal JJ cord-010092-uftc8inx 9674 29 life life NN cord-010092-uftc8inx 9674 30 or or CC cord-010092-uftc8inx 9674 31 after after IN cord-010092-uftc8inx 9674 32 blood blood NN cord-010092-uftc8inx 9674 33 progenitor progenitor NN cord-010092-uftc8inx 9674 34 cell cell NN cord-010092-uftc8inx 9674 35 transplantation transplantation NN cord-010092-uftc8inx 9674 36 . . . cord-010092-uftc8inx 9675 1 Aims aim VBZ cord-010092-uftc8inx 9675 2 : : : cord-010092-uftc8inx 9676 1 To to TO cord-010092-uftc8inx 9676 2 investigate investigate VB cord-010092-uftc8inx 9676 3 the the DT cord-010092-uftc8inx 9676 4 molecular molecular JJ cord-010092-uftc8inx 9676 5 basis basis NN cord-010092-uftc8inx 9676 6 for for IN cord-010092-uftc8inx 9676 7 ABO ABO NNP cord-010092-uftc8inx 9676 8 discrepancies discrepancy NNS cord-010092-uftc8inx 9676 9 detected detect VBN cord-010092-uftc8inx 9676 10 in in IN cord-010092-uftc8inx 9676 11 clinical clinical JJ cord-010092-uftc8inx 9676 12 samples sample NNS cord-010092-uftc8inx 9676 13 , , , cord-010092-uftc8inx 9676 14 including include VBG cord-010092-uftc8inx 9676 15 donors donor NNS cord-010092-uftc8inx 9676 16 and and CC cord-010092-uftc8inx 9676 17 patients patient NNS cord-010092-uftc8inx 9676 18 , , , cord-010092-uftc8inx 9676 19 sent send VBN cord-010092-uftc8inx 9676 20 to to IN cord-010092-uftc8inx 9676 21 our -PRON- PRP$ cord-010092-uftc8inx 9676 22 reference reference NN cord-010092-uftc8inx 9676 23 laboratory laboratory NN cord-010092-uftc8inx 9676 24 during during IN cord-010092-uftc8inx 9676 25 the the DT cord-010092-uftc8inx 9676 26 past past JJ cord-010092-uftc8inx 9676 27 3 3 CD cord-010092-uftc8inx 9676 28 years year NNS cord-010092-uftc8inx 9676 29 . . . cord-010092-uftc8inx 9677 1 Methods method NNS cord-010092-uftc8inx 9677 2 : : : cord-010092-uftc8inx 9677 3 If if IN cord-010092-uftc8inx 9677 4 routine routine JJ cord-010092-uftc8inx 9677 5 ABO ABO NNP cord-010092-uftc8inx 9677 6 grouping grouping NN cord-010092-uftc8inx 9677 7 showed show VBD cord-010092-uftc8inx 9677 8 weak weak JJ cord-010092-uftc8inx 9677 9 agglutination agglutination NN cord-010092-uftc8inx 9677 10 or or CC cord-010092-uftc8inx 9677 11 forward forward RB cord-010092-uftc8inx 9677 12 vs vs IN cord-010092-uftc8inx 9677 13 reverse reverse NN cord-010092-uftc8inx 9677 14 typing typing NN cord-010092-uftc8inx 9677 15 discrepancy discrepancy NN cord-010092-uftc8inx 9677 16 , , , cord-010092-uftc8inx 9677 17 further further RB cord-010092-uftc8inx 9677 18 ABO ABO NNP cord-010092-uftc8inx 9677 19 typing typing NN cord-010092-uftc8inx 9677 20 studies study NNS cord-010092-uftc8inx 9677 21 were be VBD cord-010092-uftc8inx 9677 22 performed perform VBN cord-010092-uftc8inx 9677 23 manually manually RB cord-010092-uftc8inx 9677 24 . . . cord-010092-uftc8inx 9678 1 Adsorption adsorption NN cord-010092-uftc8inx 9678 2 - - HYPH cord-010092-uftc8inx 9678 3 elution elution NN cord-010092-uftc8inx 9678 4 tests test NNS cord-010092-uftc8inx 9678 5 were be VBD cord-010092-uftc8inx 9678 6 also also RB cord-010092-uftc8inx 9678 7 performed perform VBN cord-010092-uftc8inx 9678 8 in in IN cord-010092-uftc8inx 9678 9 some some DT cord-010092-uftc8inx 9678 10 cases case NNS cord-010092-uftc8inx 9678 11 with with IN cord-010092-uftc8inx 9678 12 polyclonal polyclonal JJ cord-010092-uftc8inx 9678 13 anti anti JJ cord-010092-uftc8inx 9678 14 - - NNP cord-010092-uftc8inx 9678 15 A a JJ cord-010092-uftc8inx 9678 16 and and CC cord-010092-uftc8inx 9678 17 anti anti NN cord-010092-uftc8inx 9678 18 - - NN cord-010092-uftc8inx 9678 19 B b NN cord-010092-uftc8inx 9678 20 to to TO cord-010092-uftc8inx 9678 21 confirm confirm VB cord-010092-uftc8inx 9678 22 whether whether IN cord-010092-uftc8inx 9678 23 A a NN cord-010092-uftc8inx 9678 24 or or CC cord-010092-uftc8inx 9678 25 B b NN cord-010092-uftc8inx 9678 26 antigens antigen NNS cord-010092-uftc8inx 9678 27 were be VBD cord-010092-uftc8inx 9678 28 weakly weakly RB cord-010092-uftc8inx 9678 29 expressed express VBN cord-010092-uftc8inx 9678 30 on on IN cord-010092-uftc8inx 9678 31 the the DT cord-010092-uftc8inx 9678 32 RBCs rbc NNS cord-010092-uftc8inx 9678 33 membrane membrane NN cord-010092-uftc8inx 9678 34 . . . cord-010092-uftc8inx 9679 1 A a DT cord-010092-uftc8inx 9679 2 PCR PCR NNP cord-010092-uftc8inx 9679 3 approach approach NN cord-010092-uftc8inx 9679 4 using use VBG cord-010092-uftc8inx 9679 5 sequence sequence NN cord-010092-uftc8inx 9679 6 specific specific JJ cord-010092-uftc8inx 9679 7 primers primer NNS cord-010092-uftc8inx 9679 8 for for IN cord-010092-uftc8inx 9679 9 A2 a2 NN cord-010092-uftc8inx 9679 10 , , , cord-010092-uftc8inx 9679 11 B B NNP cord-010092-uftc8inx 9679 12 , , , cord-010092-uftc8inx 9679 13 O1 O1 NNP cord-010092-uftc8inx 9679 14 and and CC cord-010092-uftc8inx 9679 15 O2 O2 NNP cord-010092-uftc8inx 9679 16 alleles allele NNS cord-010092-uftc8inx 9679 17 was be VBD cord-010092-uftc8inx 9679 18 used use VBN cord-010092-uftc8inx 9679 19 for for IN cord-010092-uftc8inx 9679 20 initial initial JJ cord-010092-uftc8inx 9679 21 genotype genotype NN cord-010092-uftc8inx 9679 22 determination determination NN cord-010092-uftc8inx 9679 23 . . . cord-010092-uftc8inx 9680 1 The the DT cord-010092-uftc8inx 9680 2 full full JJ cord-010092-uftc8inx 9680 3 ABO ABO NNP cord-010092-uftc8inx 9680 4 coding coding NN cord-010092-uftc8inx 9680 5 region region NN cord-010092-uftc8inx 9680 6 was be VBD cord-010092-uftc8inx 9680 7 analysed analyse VBN cord-010092-uftc8inx 9680 8 as as IN cord-010092-uftc8inx 9680 9 previously previously RB cord-010092-uftc8inx 9680 10 described describe VBN cord-010092-uftc8inx 9680 11 in in IN cord-010092-uftc8inx 9680 12 selected select VBN cord-010092-uftc8inx 9680 13 samples sample NNS cord-010092-uftc8inx 9680 14 for for IN cord-010092-uftc8inx 9680 15 which which WDT cord-010092-uftc8inx 9680 16 ABO ABO NNP cord-010092-uftc8inx 9680 17 discrepancy discrepancy NN cord-010092-uftc8inx 9680 18 was be VBD cord-010092-uftc8inx 9680 19 still still RB cord-010092-uftc8inx 9680 20 unexplained unexplained JJ cord-010092-uftc8inx 9680 21 . . . cord-010092-uftc8inx 9681 1 Allele allele NN cord-010092-uftc8inx 9681 2 specific specific JJ cord-010092-uftc8inx 9681 3 fragments fragment NNS cord-010092-uftc8inx 9681 4 spanning span VBG cord-010092-uftc8inx 9681 5 exon exon NN cord-010092-uftc8inx 9681 6 6 6 CD cord-010092-uftc8inx 9681 7 , , , cord-010092-uftc8inx 9681 8 intron intron NN cord-010092-uftc8inx 9681 9 6 6 CD cord-010092-uftc8inx 9681 10 and and CC cord-010092-uftc8inx 9681 11 exon exon NN cord-010092-uftc8inx 9681 12 7 7 CD cord-010092-uftc8inx 9681 13 were be VBD cord-010092-uftc8inx 9681 14 amplified amplify VBN cord-010092-uftc8inx 9681 15 using use VBG cord-010092-uftc8inx 9681 16 a a DT cord-010092-uftc8inx 9681 17 forward forward JJ cord-010092-uftc8inx 9681 18 primer primer NN cord-010092-uftc8inx 9681 19 targeting target VBG cord-010092-uftc8inx 9681 20 the the DT cord-010092-uftc8inx 9681 21 261 261 CD cord-010092-uftc8inx 9681 22 G g NN cord-010092-uftc8inx 9681 23 nucleotide nucleotide NN cord-010092-uftc8inx 9681 24 ( ( -LRB- cord-010092-uftc8inx 9681 25 to to TO cord-010092-uftc8inx 9681 26 exclude exclude VB cord-010092-uftc8inx 9681 27 O1 o1 NN cord-010092-uftc8inx 9681 28 alleles allele NNS cord-010092-uftc8inx 9681 29 amplification amplification NN cord-010092-uftc8inx 9681 30 ) ) -RRB- cord-010092-uftc8inx 9681 31 in in IN cord-010092-uftc8inx 9681 32 combination combination NN cord-010092-uftc8inx 9681 33 with with IN cord-010092-uftc8inx 9681 34 either either DT cord-010092-uftc8inx 9681 35 B B NNP cord-010092-uftc8inx 9681 36 , , , cord-010092-uftc8inx 9681 37 A2 A2 NNP cord-010092-uftc8inx 9681 38 or or CC cord-010092-uftc8inx 9681 39 a a DT cord-010092-uftc8inx 9681 40 generic generic JJ cord-010092-uftc8inx 9681 41 reverse reverse NN cord-010092-uftc8inx 9681 42 primer primer NN cord-010092-uftc8inx 9681 43 . . . cord-010092-uftc8inx 9682 1 Analysis analysis NN cord-010092-uftc8inx 9682 2 was be VBD cord-010092-uftc8inx 9682 3 carried carry VBN cord-010092-uftc8inx 9682 4 out out RP cord-010092-uftc8inx 9682 5 by by IN cord-010092-uftc8inx 9682 6 Sanger Sanger NNP cord-010092-uftc8inx 9682 7 sequencing sequencing NN cord-010092-uftc8inx 9682 8 . . . cord-010092-uftc8inx 9683 1 Results result NNS cord-010092-uftc8inx 9683 2 : : : cord-010092-uftc8inx 9684 1 A a DT cord-010092-uftc8inx 9684 2 total total NN cord-010092-uftc8inx 9684 3 of of IN cord-010092-uftc8inx 9684 4 16 16 CD cord-010092-uftc8inx 9684 5 samples sample NNS cord-010092-uftc8inx 9684 6 with with IN cord-010092-uftc8inx 9684 7 suspected suspect VBN cord-010092-uftc8inx 9684 8 inherited inherit VBN cord-010092-uftc8inx 9684 9 ABO ABO NNP cord-010092-uftc8inx 9684 10 subgroup subgroup NN cord-010092-uftc8inx 9684 11 alleles allele NNS cord-010092-uftc8inx 9684 12 were be VBD cord-010092-uftc8inx 9684 13 selected select VBN cord-010092-uftc8inx 9684 14 for for IN cord-010092-uftc8inx 9684 15 further further JJ cord-010092-uftc8inx 9684 16 molecular molecular JJ cord-010092-uftc8inx 9684 17 studies study NNS cord-010092-uftc8inx 9684 18 by by IN cord-010092-uftc8inx 9684 19 sequence sequence NN cord-010092-uftc8inx 9684 20 analysis analysis NN cord-010092-uftc8inx 9684 21 . . . cord-010092-uftc8inx 9685 1 A a DT cord-010092-uftc8inx 9685 2 subgroup subgroup NN cord-010092-uftc8inx 9685 3 alleles allele NNS cord-010092-uftc8inx 9685 4 : : : cord-010092-uftc8inx 9685 5 in in IN cord-010092-uftc8inx 9685 6 8 8 CD cord-010092-uftc8inx 9685 7 out out IN cord-010092-uftc8inx 9685 8 of of IN cord-010092-uftc8inx 9685 9 12 12 CD cord-010092-uftc8inx 9685 10 samples sample NNS cord-010092-uftc8inx 9685 11 with with IN cord-010092-uftc8inx 9685 12 suspected suspect VBN cord-010092-uftc8inx 9685 13 A a DT cord-010092-uftc8inx 9685 14 subgroup subgroup NN cord-010092-uftc8inx 9685 15 alleles allele NNS cord-010092-uftc8inx 9685 16 , , , cord-010092-uftc8inx 9685 17 the the DT cord-010092-uftc8inx 9685 18 c.804insG c.804insg CD cord-010092-uftc8inx 9685 19 insertion insertion NN cord-010092-uftc8inx 9685 20 was be VBD cord-010092-uftc8inx 9685 21 detected detect VBN cord-010092-uftc8inx 9685 22 corresponding correspond VBG cord-010092-uftc8inx 9685 23 to to IN cord-010092-uftc8inx 9685 24 the the DT cord-010092-uftc8inx 9685 25 ABO*Ael.01 ABO*Ael.01 NNP cord-010092-uftc8inx 9685 26 allele allele NN cord-010092-uftc8inx 9685 27 . . . cord-010092-uftc8inx 9686 1 The the DT cord-010092-uftc8inx 9686 2 ABO*Aw31.02 ABO*Aw31.02 NNP cord-010092-uftc8inx 9686 3 - - HYPH cord-010092-uftc8inx 9686 4 05 05 CD cord-010092-uftc8inx 9686 5 variant variant NN cord-010092-uftc8inx 9686 6 , , , cord-010092-uftc8inx 9686 7 a a DT cord-010092-uftc8inx 9686 8 hybrid hybrid JJ cord-010092-uftc8inx 9686 9 A1-O1v A1-O1v NNP cord-010092-uftc8inx 9686 10 allele allele NN cord-010092-uftc8inx 9686 11 , , , cord-010092-uftc8inx 9686 12 was be VBD cord-010092-uftc8inx 9686 13 found find VBN cord-010092-uftc8inx 9686 14 in in IN cord-010092-uftc8inx 9686 15 2 2 CD cord-010092-uftc8inx 9686 16 cases case NNS cord-010092-uftc8inx 9686 17 . . . cord-010092-uftc8inx 9687 1 In in IN cord-010092-uftc8inx 9687 2 1 1 CD cord-010092-uftc8inx 9687 3 case case NN cord-010092-uftc8inx 9687 4 we -PRON- PRP cord-010092-uftc8inx 9687 5 found find VBD cord-010092-uftc8inx 9687 6 the the DT cord-010092-uftc8inx 9687 7 c.722 c.722 NN cord-010092-uftc8inx 9687 8 G g NN cord-010092-uftc8inx 9687 9 > > XX cord-010092-uftc8inx 9688 1 C C NNP cord-010092-uftc8inx 9688 2 change change NN cord-010092-uftc8inx 9688 3 , , , cord-010092-uftc8inx 9688 4 previously previously RB cord-010092-uftc8inx 9688 5 reported report VBD cord-010092-uftc8inx 9688 6 associated associate VBN cord-010092-uftc8inx 9688 7 with with IN cord-010092-uftc8inx 9688 8 weak weak JJ cord-010092-uftc8inx 9688 9 A a DT cord-010092-uftc8inx 9688 10 antigen antigen NN cord-010092-uftc8inx 9688 11 expression expression NN cord-010092-uftc8inx 9688 12 . . . cord-010092-uftc8inx 9689 1 Finally finally RB cord-010092-uftc8inx 9689 2 , , , cord-010092-uftc8inx 9689 3 a a DT cord-010092-uftc8inx 9689 4 novel novel NN cord-010092-uftc8inx 9690 1 c.961C c.961C NNP cord-010092-uftc8inx 9690 2 > > XX cord-010092-uftc8inx 9691 1 G g NN cord-010092-uftc8inx 9691 2 change change NN cord-010092-uftc8inx 9691 3 was be VBD cord-010092-uftc8inx 9691 4 detected detect VBN cord-010092-uftc8inx 9691 5 in in IN cord-010092-uftc8inx 9691 6 an an DT cord-010092-uftc8inx 9691 7 A2 A2 NNP cord-010092-uftc8inx 9691 8 allele allele NN cord-010092-uftc8inx 9691 9 . . . cord-010092-uftc8inx 9692 1 B(A B(A NNP cord-010092-uftc8inx 9692 2 ) ) -RRB- cord-010092-uftc8inx 9692 3 or or CC cord-010092-uftc8inx 9692 4 cis cis NNP cord-010092-uftc8inx 9692 5 - - HYPH cord-010092-uftc8inx 9692 6 AB AB NNP cord-010092-uftc8inx 9692 7 suspected suspect VBN cord-010092-uftc8inx 9692 8 alleles allele NNS cord-010092-uftc8inx 9692 9 : : : cord-010092-uftc8inx 9693 1 The the DT cord-010092-uftc8inx 9693 2 ABO*B(A)04 ABO*B(A)04 NNPS cord-010092-uftc8inx 9693 3 variant variant NN cord-010092-uftc8inx 9693 4 carrying carry VBG cord-010092-uftc8inx 9693 5 the the DT cord-010092-uftc8inx 9693 6 c.640A c.640A NNP cord-010092-uftc8inx 9694 1 > > XX cord-010092-uftc8inx 9695 1 G g NN cord-010092-uftc8inx 9695 2 change change NN cord-010092-uftc8inx 9695 3 was be VBD cord-010092-uftc8inx 9695 4 found find VBN cord-010092-uftc8inx 9695 5 in in IN cord-010092-uftc8inx 9695 6 1 1 CD cord-010092-uftc8inx 9695 7 of of IN cord-010092-uftc8inx 9695 8 3 3 CD cord-010092-uftc8inx 9695 9 samples sample NNS cord-010092-uftc8inx 9695 10 with with IN cord-010092-uftc8inx 9695 11 BO1 BO1 NNP cord-010092-uftc8inx 9695 12 genotype genotype NN cord-010092-uftc8inx 9695 13 but but CC cord-010092-uftc8inx 9695 14 A a DT cord-010092-uftc8inx 9695 15 weak weak JJ cord-010092-uftc8inx 9695 16 antigen antigen NN cord-010092-uftc8inx 9695 17 expression expression NN cord-010092-uftc8inx 9695 18 . . . cord-010092-uftc8inx 9696 1 In in IN cord-010092-uftc8inx 9696 2 the the DT cord-010092-uftc8inx 9696 3 remaining remain VBG cord-010092-uftc8inx 9696 4 2 2 CD cord-010092-uftc8inx 9696 5 cases case NNS cord-010092-uftc8inx 9696 6 , , , cord-010092-uftc8inx 9696 7 a a DT cord-010092-uftc8inx 9696 8 consensus consensus NN cord-010092-uftc8inx 9696 9 B b NN cord-010092-uftc8inx 9696 10 allele allele NN cord-010092-uftc8inx 9696 11 was be VBD cord-010092-uftc8inx 9696 12 detected detect VBN cord-010092-uftc8inx 9696 13 , , , cord-010092-uftc8inx 9696 14 thus thus RB cord-010092-uftc8inx 9696 15 pointing point VBG cord-010092-uftc8inx 9696 16 to to IN cord-010092-uftc8inx 9696 17 a a DT cord-010092-uftc8inx 9696 18 potential potential JJ cord-010092-uftc8inx 9696 19 chimerism chimerism NN cord-010092-uftc8inx 9696 20 as as IN cord-010092-uftc8inx 9696 21 the the DT cord-010092-uftc8inx 9696 22 cause cause NN cord-010092-uftc8inx 9696 23 of of IN cord-010092-uftc8inx 9696 24 the the DT cord-010092-uftc8inx 9696 25 results result NNS cord-010092-uftc8inx 9696 26 observed observe VBN cord-010092-uftc8inx 9696 27 in in IN cord-010092-uftc8inx 9696 28 ABO ABO NNP cord-010092-uftc8inx 9696 29 grouping grouping NN cord-010092-uftc8inx 9696 30 . . . cord-010092-uftc8inx 9697 1 Finally finally RB cord-010092-uftc8inx 9697 2 , , , cord-010092-uftc8inx 9697 3 we -PRON- PRP cord-010092-uftc8inx 9697 4 have have VBP cord-010092-uftc8inx 9697 5 identified identify VBN cord-010092-uftc8inx 9697 6 an an DT cord-010092-uftc8inx 9697 7 ABO*B01.02 ABO*B01.02 `` cord-010092-uftc8inx 9697 8 allele allele NN cord-010092-uftc8inx 9697 9 carrying carry VBG cord-010092-uftc8inx 9697 10 the the DT cord-010092-uftc8inx 9697 11 nucleotidic nucleotidic NNP cord-010092-uftc8inx 9697 12 change change NN cord-010092-uftc8inx 9697 13 c.926A c.926A NNP cord-010092-uftc8inx 9698 1 > > XX cord-010092-uftc8inx 9699 1 G g NN cord-010092-uftc8inx 9699 2 in in IN cord-010092-uftc8inx 9699 3 the the DT cord-010092-uftc8inx 9699 4 context context NN cord-010092-uftc8inx 9699 5 of of IN cord-010092-uftc8inx 9699 6 an an DT cord-010092-uftc8inx 9699 7 ABO ABO NNP cord-010092-uftc8inx 9699 8 phenotype phenotype NN cord-010092-uftc8inx 9699 9 vs vs IN cord-010092-uftc8inx 9699 10 genotype genotype NN cord-010092-uftc8inx 9699 11 discrepancy discrepancy NN cord-010092-uftc8inx 9699 12 . . . cord-010092-uftc8inx 9700 1 Summary Summary NNP cord-010092-uftc8inx 9700 2 / / SYM cord-010092-uftc8inx 9700 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 9700 4 : : : cord-010092-uftc8inx 9701 1 The the DT cord-010092-uftc8inx 9701 2 Sanger Sanger NNP cord-010092-uftc8inx 9701 3 sequencing sequencing NN cord-010092-uftc8inx 9701 4 approach approach NN cord-010092-uftc8inx 9701 5 applied apply VBN cord-010092-uftc8inx 9701 6 in in IN cord-010092-uftc8inx 9701 7 this this DT cord-010092-uftc8inx 9701 8 study study NN cord-010092-uftc8inx 9701 9 have have VBP cord-010092-uftc8inx 9701 10 proved prove VBN cord-010092-uftc8inx 9701 11 to to TO cord-010092-uftc8inx 9701 12 be be VB cord-010092-uftc8inx 9701 13 informative informative JJ cord-010092-uftc8inx 9701 14 and and CC cord-010092-uftc8inx 9701 15 helpful helpful JJ cord-010092-uftc8inx 9701 16 to to TO cord-010092-uftc8inx 9701 17 determine determine VB cord-010092-uftc8inx 9701 18 the the DT cord-010092-uftc8inx 9701 19 molecular molecular JJ cord-010092-uftc8inx 9701 20 basis basis NN cord-010092-uftc8inx 9701 21 of of IN cord-010092-uftc8inx 9701 22 ABO ABO NNP cord-010092-uftc8inx 9701 23 grouping group VBG cord-010092-uftc8inx 9701 24 discrepancies discrepancy NNS cord-010092-uftc8inx 9701 25 with with IN cord-010092-uftc8inx 9701 26 suspected suspect VBN cord-010092-uftc8inx 9701 27 inherited inherit VBN cord-010092-uftc8inx 9701 28 subgroups subgroup NNS cord-010092-uftc8inx 9701 29 . . . cord-010092-uftc8inx 9702 1 We -PRON- PRP cord-010092-uftc8inx 9702 2 found find VBD cord-010092-uftc8inx 9702 3 mutations mutation NNS cord-010092-uftc8inx 9702 4 , , , cord-010092-uftc8inx 9702 5 within within IN cord-010092-uftc8inx 9702 6 exon exon NN cord-010092-uftc8inx 9702 7 7 7 CD cord-010092-uftc8inx 9702 8 of of IN cord-010092-uftc8inx 9702 9 the the DT cord-010092-uftc8inx 9702 10 ABO ABO NNP cord-010092-uftc8inx 9702 11 gene gene NN cord-010092-uftc8inx 9702 12 , , , cord-010092-uftc8inx 9702 13 in in IN cord-010092-uftc8inx 9702 14 14 14 CD cord-010092-uftc8inx 9702 15 out out IN cord-010092-uftc8inx 9702 16 of of IN cord-010092-uftc8inx 9702 17 16 16 CD cord-010092-uftc8inx 9702 18 samples sample NNS cord-010092-uftc8inx 9702 19 , , , cord-010092-uftc8inx 9702 20 including include VBG cord-010092-uftc8inx 9702 21 2 2 CD cord-010092-uftc8inx 9702 22 novel novel NN cord-010092-uftc8inx 9702 23 alleles allele NNS cord-010092-uftc8inx 9702 24 . . . cord-010092-uftc8inx 9703 1 Chimerism chimerism NN cord-010092-uftc8inx 9703 2 was be VBD cord-010092-uftc8inx 9703 3 suspected suspect VBN cord-010092-uftc8inx 9703 4 in in IN cord-010092-uftc8inx 9703 5 2 2 CD cord-010092-uftc8inx 9703 6 cases case NNS cord-010092-uftc8inx 9703 7 of of IN cord-010092-uftc8inx 9703 8 A a DT cord-010092-uftc8inx 9703 9 antigen antigen NN cord-010092-uftc8inx 9703 10 expression expression NN cord-010092-uftc8inx 9703 11 in in IN cord-010092-uftc8inx 9703 12 samples sample NNS cord-010092-uftc8inx 9703 13 with with IN cord-010092-uftc8inx 9703 14 B1O1 B1O1 NNP cord-010092-uftc8inx 9703 15 genetic genetic JJ cord-010092-uftc8inx 9703 16 background background NN cord-010092-uftc8inx 9703 17 carrying carry VBG cord-010092-uftc8inx 9703 18 an an DT cord-010092-uftc8inx 9703 19 apparent apparent JJ cord-010092-uftc8inx 9703 20 normal normal JJ cord-010092-uftc8inx 9703 21 B b NN cord-010092-uftc8inx 9703 22 allele allele NN cord-010092-uftc8inx 9703 23 . . . cord-010092-uftc8inx 9704 1 We -PRON- PRP cord-010092-uftc8inx 9704 2 are be VBP cord-010092-uftc8inx 9704 3 evaluating evaluate VBG cord-010092-uftc8inx 9704 4 at at IN cord-010092-uftc8inx 9704 5 the the DT cord-010092-uftc8inx 9704 6 moment moment NN cord-010092-uftc8inx 9704 7 a a DT cord-010092-uftc8inx 9704 8 deep deep JJ cord-010092-uftc8inx 9704 9 sequencing sequencing NN cord-010092-uftc8inx 9704 10 approach approach NN cord-010092-uftc8inx 9704 11 by by IN cord-010092-uftc8inx 9704 12 Next Next NNP cord-010092-uftc8inx 9704 13 Generation Generation NNP cord-010092-uftc8inx 9704 14 Sequencing Sequencing NNP cord-010092-uftc8inx 9704 15 to to TO cord-010092-uftc8inx 9704 16 determine determine VB cord-010092-uftc8inx 9704 17 the the DT cord-010092-uftc8inx 9704 18 presence presence NN cord-010092-uftc8inx 9704 19 of of IN cord-010092-uftc8inx 9704 20 a a DT cord-010092-uftc8inx 9704 21 small small JJ cord-010092-uftc8inx 9704 22 amount amount NN cord-010092-uftc8inx 9704 23 of of IN cord-010092-uftc8inx 9704 24 a a DT cord-010092-uftc8inx 9704 25 minor minor JJ cord-010092-uftc8inx 9704 26 allele allele NN cord-010092-uftc8inx 9704 27 in in IN cord-010092-uftc8inx 9704 28 the the DT cord-010092-uftc8inx 9704 29 presence presence NN cord-010092-uftc8inx 9704 30 of of IN cord-010092-uftc8inx 9704 31 a a DT cord-010092-uftc8inx 9704 32 large large JJ cord-010092-uftc8inx 9704 33 surplus surplus NN cord-010092-uftc8inx 9704 34 of of IN cord-010092-uftc8inx 9704 35 the the DT cord-010092-uftc8inx 9704 36 other other JJ cord-010092-uftc8inx 9704 37 two two CD cord-010092-uftc8inx 9704 38 alleles allele NNS cord-010092-uftc8inx 9704 39 . . . cord-010092-uftc8inx 9705 1 Background background NN cord-010092-uftc8inx 9705 2 : : : cord-010092-uftc8inx 9706 1 Recently recently RB cord-010092-uftc8inx 9706 2 , , , cord-010092-uftc8inx 9706 3 the the DT cord-010092-uftc8inx 9706 4 multiple multiple JJ cord-010092-uftc8inx 9706 5 pregnancy pregnancy NN cord-010092-uftc8inx 9706 6 rate rate NN cord-010092-uftc8inx 9706 7 has have VBZ cord-010092-uftc8inx 9706 8 been be VBN cord-010092-uftc8inx 9706 9 increasing increase VBG cord-010092-uftc8inx 9706 10 due due IN cord-010092-uftc8inx 9706 11 to to IN cord-010092-uftc8inx 9706 12 advances advance NNS cord-010092-uftc8inx 9706 13 in in IN cord-010092-uftc8inx 9706 14 artificial artificial JJ cord-010092-uftc8inx 9706 15 fertilization fertilization NN cord-010092-uftc8inx 9706 16 including include VBG cord-010092-uftc8inx 9706 17 in in IN cord-010092-uftc8inx 9706 18 vitro vitro FW cord-010092-uftc8inx 9706 19 fertilization fertilization NN cord-010092-uftc8inx 9706 20 - - HYPH cord-010092-uftc8inx 9706 21 embryo embryo NN cord-010092-uftc8inx 9706 22 transfer transfer NN cord-010092-uftc8inx 9706 23 . . . cord-010092-uftc8inx 9707 1 Most Most JJS cord-010092-uftc8inx 9707 2 dizygotic dizygotic VBN cord-010092-uftc8inx 9707 3 twins twin NNS cord-010092-uftc8inx 9707 4 have have VBP cord-010092-uftc8inx 9707 5 dichorionic dichorionic JJ cord-010092-uftc8inx 9707 6 placenta placenta NN cord-010092-uftc8inx 9707 7 , , , cord-010092-uftc8inx 9707 8 but but CC cord-010092-uftc8inx 9707 9 8 8 CD cord-010092-uftc8inx 9707 10 % % NN cord-010092-uftc8inx 9707 11 of of IN cord-010092-uftc8inx 9707 12 them -PRON- PRP cord-010092-uftc8inx 9707 13 share share VBP cord-010092-uftc8inx 9707 14 the the DT cord-010092-uftc8inx 9707 15 placenta placenta NN cord-010092-uftc8inx 9707 16 . . . cord-010092-uftc8inx 9708 1 Monochorionic monochorionic JJ cord-010092-uftc8inx 9708 2 dizygotic dizygotic VBN cord-010092-uftc8inx 9708 3 twins twin NNS cord-010092-uftc8inx 9708 4 can can MD cord-010092-uftc8inx 9708 5 have have VB cord-010092-uftc8inx 9708 6 blood blood NN cord-010092-uftc8inx 9708 7 chimerism chimerism NN cord-010092-uftc8inx 9708 8 , , , cord-010092-uftc8inx 9708 9 leading lead VBG cord-010092-uftc8inx 9708 10 to to IN cord-010092-uftc8inx 9708 11 double double VB cord-010092-uftc8inx 9708 12 RBC RBC NNP cord-010092-uftc8inx 9708 13 populations population NNS cord-010092-uftc8inx 9708 14 in in IN cord-010092-uftc8inx 9708 15 routine routine JJ cord-010092-uftc8inx 9708 16 ABO ABO NNP cord-010092-uftc8inx 9708 17 serologic serologic NN cord-010092-uftc8inx 9708 18 typing typing NN cord-010092-uftc8inx 9708 19 . . . cord-010092-uftc8inx 9709 1 Recently recently RB cord-010092-uftc8inx 9709 2 , , , cord-010092-uftc8inx 9709 3 more more RBR cord-010092-uftc8inx 9709 4 sensitive sensitive JJ cord-010092-uftc8inx 9709 5 and and CC cord-010092-uftc8inx 9709 6 objective objective JJ cord-010092-uftc8inx 9709 7 column column NN cord-010092-uftc8inx 9709 8 agglutination agglutination NN cord-010092-uftc8inx 9709 9 tests test NNS cord-010092-uftc8inx 9709 10 with with IN cord-010092-uftc8inx 9709 11 automated automate VBN cord-010092-uftc8inx 9709 12 systems system NNS cord-010092-uftc8inx 9709 13 are be VBP cord-010092-uftc8inx 9709 14 being be VBG cord-010092-uftc8inx 9709 15 widely widely RB cord-010092-uftc8inx 9709 16 used use VBN cord-010092-uftc8inx 9709 17 . . . cord-010092-uftc8inx 9710 1 Therefore therefore RB cord-010092-uftc8inx 9710 2 , , , cord-010092-uftc8inx 9710 3 blood blood NN cord-010092-uftc8inx 9710 4 chimerisms chimerism NNS cord-010092-uftc8inx 9710 5 in in IN cord-010092-uftc8inx 9710 6 dizygotic dizygotic JJ cord-010092-uftc8inx 9710 7 twins twin NNS cord-010092-uftc8inx 9710 8 can can MD cord-010092-uftc8inx 9710 9 be be VB cord-010092-uftc8inx 9710 10 detected detect VBN cord-010092-uftc8inx 9710 11 more more RBR cord-010092-uftc8inx 9710 12 easily easily RB cord-010092-uftc8inx 9710 13 by by IN cord-010092-uftc8inx 9710 14 routine routine JJ cord-010092-uftc8inx 9710 15 ABO ABO NNP cord-010092-uftc8inx 9710 16 blood blood NN cord-010092-uftc8inx 9710 17 typing typing NN cord-010092-uftc8inx 9710 18 . . . cord-010092-uftc8inx 9711 1 Aims aim VBZ cord-010092-uftc8inx 9711 2 : : : cord-010092-uftc8inx 9712 1 We -PRON- PRP cord-010092-uftc8inx 9712 2 report report VBP cord-010092-uftc8inx 9712 3 congenital congenital JJ cord-010092-uftc8inx 9712 4 blood blood NN cord-010092-uftc8inx 9712 5 chimerism chimerism NN cord-010092-uftc8inx 9712 6 in in IN cord-010092-uftc8inx 9712 7 monochorionic monochorionic JJ cord-010092-uftc8inx 9712 8 dizygotic dizygotic JJ cord-010092-uftc8inx 9712 9 twins twin NNS cord-010092-uftc8inx 9712 10 of of IN cord-010092-uftc8inx 9712 11 triplets triplet NNS cord-010092-uftc8inx 9712 12 , , , cord-010092-uftc8inx 9712 13 found find VBN cord-010092-uftc8inx 9712 14 incidentally incidentally RB cord-010092-uftc8inx 9712 15 during during IN cord-010092-uftc8inx 9712 16 ABO ABO NNP cord-010092-uftc8inx 9712 17 serological serological JJ cord-010092-uftc8inx 9712 18 testing testing NN cord-010092-uftc8inx 9712 19 and and CC cord-010092-uftc8inx 9712 20 confirmed confirm VBN cord-010092-uftc8inx 9712 21 by by IN cord-010092-uftc8inx 9712 22 ABO ABO NNP cord-010092-uftc8inx 9712 23 genotyping genotyping NN cord-010092-uftc8inx 9712 24 and and CC cord-010092-uftc8inx 9712 25 STR str NN cord-010092-uftc8inx 9712 26 marker marker NN cord-010092-uftc8inx 9712 27 analysis analysis NN cord-010092-uftc8inx 9712 28 . . . cord-010092-uftc8inx 9713 1 Methods method NNS cord-010092-uftc8inx 9713 2 : : : cord-010092-uftc8inx 9713 3 A a DT cord-010092-uftc8inx 9713 4 20-year 20-year JJ cord-010092-uftc8inx 9713 5 - - HYPH cord-010092-uftc8inx 9713 6 old old JJ cord-010092-uftc8inx 9713 7 male male NN cord-010092-uftc8inx 9713 8 ( ( -LRB- cord-010092-uftc8inx 9713 9 one one CD cord-010092-uftc8inx 9713 10 of of IN cord-010092-uftc8inx 9713 11 triplets triplet NNS cord-010092-uftc8inx 9713 12 ) ) -RRB- cord-010092-uftc8inx 9713 13 was be VBD cord-010092-uftc8inx 9713 14 admitted admit VBN cord-010092-uftc8inx 9713 15 to to IN cord-010092-uftc8inx 9713 16 the the DT cord-010092-uftc8inx 9713 17 hospital hospital NN cord-010092-uftc8inx 9713 18 for for IN cord-010092-uftc8inx 9713 19 medical medical JJ cord-010092-uftc8inx 9713 20 checkup checkup NN cord-010092-uftc8inx 9713 21 . . . cord-010092-uftc8inx 9714 1 He -PRON- PRP cord-010092-uftc8inx 9714 2 did do VBD cord-010092-uftc8inx 9714 3 not not RB cord-010092-uftc8inx 9714 4 have have VB cord-010092-uftc8inx 9714 5 any any DT cord-010092-uftc8inx 9714 6 history history NN cord-010092-uftc8inx 9714 7 of of IN cord-010092-uftc8inx 9714 8 transfusion transfusion NN cord-010092-uftc8inx 9714 9 or or CC cord-010092-uftc8inx 9714 10 bone bone NN cord-010092-uftc8inx 9714 11 marrow marrow NN cord-010092-uftc8inx 9714 12 transplantation transplantation NN cord-010092-uftc8inx 9714 13 . . . cord-010092-uftc8inx 9715 1 Routine routine JJ cord-010092-uftc8inx 9715 2 ABO ABO NNP cord-010092-uftc8inx 9715 3 blood blood NN cord-010092-uftc8inx 9715 4 grouping grouping NN cord-010092-uftc8inx 9715 5 test test NN cord-010092-uftc8inx 9715 6 was be VBD cord-010092-uftc8inx 9715 7 performed perform VBN cord-010092-uftc8inx 9715 8 using use VBG cord-010092-uftc8inx 9715 9 automated automate VBN cord-010092-uftc8inx 9715 10 blood blood NN cord-010092-uftc8inx 9715 11 bank bank NN cord-010092-uftc8inx 9715 12 system system NN cord-010092-uftc8inx 9715 13 IH-500 IH-500 NNP cord-010092-uftc8inx 9715 14 ; ; : cord-010092-uftc8inx 9715 15 however however RB cord-010092-uftc8inx 9715 16 , , , cord-010092-uftc8inx 9715 17 it -PRON- PRP cord-010092-uftc8inx 9715 18 showed show VBD cord-010092-uftc8inx 9715 19 ABO ABO NNP cord-010092-uftc8inx 9715 20 discrepancy discrepancy NN cord-010092-uftc8inx 9715 21 . . . cord-010092-uftc8inx 9716 1 The the DT cord-010092-uftc8inx 9716 2 red red JJ cord-010092-uftc8inx 9716 3 blood blood NN cord-010092-uftc8inx 9716 4 cells cell NNS cord-010092-uftc8inx 9716 5 showed show VBD cord-010092-uftc8inx 9716 6 double double JJ cord-010092-uftc8inx 9716 7 cell cell NN cord-010092-uftc8inx 9716 8 populations population NNS cord-010092-uftc8inx 9716 9 in in IN cord-010092-uftc8inx 9716 10 a a DT cord-010092-uftc8inx 9716 11 gel gel NN cord-010092-uftc8inx 9716 12 column column NN cord-010092-uftc8inx 9716 13 with with IN cord-010092-uftc8inx 9716 14 anti anti JJ cord-010092-uftc8inx 9716 15 - - JJ cord-010092-uftc8inx 9716 16 A a JJ cord-010092-uftc8inx 9716 17 and and CC cord-010092-uftc8inx 9716 18 anti anti JJ cord-010092-uftc8inx 9716 19 - - JJ cord-010092-uftc8inx 9716 20 B. B. NNP cord-010092-uftc8inx 9716 21 We -PRON- PRP cord-010092-uftc8inx 9716 22 carried carry VBD cord-010092-uftc8inx 9716 23 out out RP cord-010092-uftc8inx 9716 24 ABO ABO NNP cord-010092-uftc8inx 9716 25 genotyping genotype VBG cord-010092-uftc8inx 9716 26 both both CC cord-010092-uftc8inx 9716 27 from from IN cord-010092-uftc8inx 9716 28 the the DT cord-010092-uftc8inx 9716 29 blood blood NN cord-010092-uftc8inx 9716 30 and and CC cord-010092-uftc8inx 9716 31 from from IN cord-010092-uftc8inx 9716 32 a a DT cord-010092-uftc8inx 9716 33 buccal buccal JJ cord-010092-uftc8inx 9716 34 swab swab NN cord-010092-uftc8inx 9716 35 . . . cord-010092-uftc8inx 9717 1 For for IN cord-010092-uftc8inx 9717 2 the the DT cord-010092-uftc8inx 9717 3 further further JJ cord-010092-uftc8inx 9717 4 evaluation evaluation NN cord-010092-uftc8inx 9717 5 , , , cord-010092-uftc8inx 9717 6 we -PRON- PRP cord-010092-uftc8inx 9717 7 performed perform VBD cord-010092-uftc8inx 9717 8 ABO ABO NNP cord-010092-uftc8inx 9717 9 serologic serologic NN cord-010092-uftc8inx 9717 10 testing testing NN cord-010092-uftc8inx 9717 11 , , , cord-010092-uftc8inx 9717 12 ABO ABO NNP cord-010092-uftc8inx 9717 13 genotyping genotyping NN cord-010092-uftc8inx 9717 14 , , , cord-010092-uftc8inx 9717 15 and and CC cord-010092-uftc8inx 9717 16 STR str NN cord-010092-uftc8inx 9717 17 marker marker NN cord-010092-uftc8inx 9717 18 analysis analysis NN cord-010092-uftc8inx 9717 19 in in IN cord-010092-uftc8inx 9717 20 his -PRON- PRP$ cord-010092-uftc8inx 9717 21 family family NN cord-010092-uftc8inx 9717 22 members member NNS cord-010092-uftc8inx 9717 23 . . . cord-010092-uftc8inx 9718 1 Results result NNS cord-010092-uftc8inx 9718 2 : : : cord-010092-uftc8inx 9719 1 Among among IN cord-010092-uftc8inx 9719 2 the the DT cord-010092-uftc8inx 9719 3 triplets triplet NNS cord-010092-uftc8inx 9719 4 , , , cord-010092-uftc8inx 9719 5 blood blood NN cord-010092-uftc8inx 9719 6 chimerism chimerism NN cord-010092-uftc8inx 9719 7 was be VBD cord-010092-uftc8inx 9719 8 demonstrated demonstrate VBN cord-010092-uftc8inx 9719 9 in in IN cord-010092-uftc8inx 9719 10 the the DT cord-010092-uftc8inx 9719 11 patient patient NN cord-010092-uftc8inx 9719 12 and and CC cord-010092-uftc8inx 9719 13 his -PRON- PRP$ cord-010092-uftc8inx 9719 14 brother brother NN cord-010092-uftc8inx 9719 15 . . . cord-010092-uftc8inx 9720 1 They -PRON- PRP cord-010092-uftc8inx 9720 2 both both DT cord-010092-uftc8inx 9720 3 showed show VBD cord-010092-uftc8inx 9720 4 A a DT cord-010092-uftc8inx 9720 5 3 3 CD cord-010092-uftc8inx 9720 6 B b NN cord-010092-uftc8inx 9720 7 3 3 CD cord-010092-uftc8inx 9720 8 phenotypes phenotype NNS cord-010092-uftc8inx 9720 9 in in IN cord-010092-uftc8inx 9720 10 the the DT cord-010092-uftc8inx 9720 11 serologic serologic NNP cord-010092-uftc8inx 9720 12 test test NN cord-010092-uftc8inx 9720 13 and and CC cord-010092-uftc8inx 9720 14 tri tri JJ cord-010092-uftc8inx 9720 15 - - JJ cord-010092-uftc8inx 9720 16 allelic allelic JJ cord-010092-uftc8inx 9720 17 ABO ABO NNP cord-010092-uftc8inx 9720 18 genotypes genotype NNS cord-010092-uftc8inx 9720 19 in in IN cord-010092-uftc8inx 9720 20 the the DT cord-010092-uftc8inx 9720 21 blood blood NN cord-010092-uftc8inx 9720 22 , , , cord-010092-uftc8inx 9720 23 A102 A102 NNP cord-010092-uftc8inx 9720 24 / / SYM cord-010092-uftc8inx 9720 25 B101 B101 NNP cord-010092-uftc8inx 9720 26 / / SYM cord-010092-uftc8inx 9720 27 O01 O01 NNP cord-010092-uftc8inx 9720 28 . . . cord-010092-uftc8inx 9721 1 However however RB cord-010092-uftc8inx 9721 2 , , , cord-010092-uftc8inx 9721 3 in in IN cord-010092-uftc8inx 9721 4 buccal buccal JJ cord-010092-uftc8inx 9721 5 swabs swab NNS cord-010092-uftc8inx 9721 6 , , , cord-010092-uftc8inx 9721 7 the the DT cord-010092-uftc8inx 9721 8 patient patient NN cord-010092-uftc8inx 9721 9 showed show VBD cord-010092-uftc8inx 9721 10 A102 A102 NNP cord-010092-uftc8inx 9721 11 / / SYM cord-010092-uftc8inx 9721 12 O01 O01 NNP cord-010092-uftc8inx 9721 13 and and CC cord-010092-uftc8inx 9721 14 his -PRON- PRP$ cord-010092-uftc8inx 9721 15 brother brother NN cord-010092-uftc8inx 9721 16 showed show VBD cord-010092-uftc8inx 9721 17 B101 B101 NNP cord-010092-uftc8inx 9721 18 / / SYM cord-010092-uftc8inx 9721 19 O01 O01 NNP cord-010092-uftc8inx 9721 20 . . . cord-010092-uftc8inx 9722 1 Other other JJ cord-010092-uftc8inx 9722 2 members member NNS cord-010092-uftc8inx 9722 3 of of IN cord-010092-uftc8inx 9722 4 the the DT cord-010092-uftc8inx 9722 5 family family NN cord-010092-uftc8inx 9722 6 ( ( -LRB- cord-010092-uftc8inx 9722 7 father father NN cord-010092-uftc8inx 9722 8 , , , cord-010092-uftc8inx 9722 9 mother mother NN cord-010092-uftc8inx 9722 10 , , , cord-010092-uftc8inx 9722 11 and and CC cord-010092-uftc8inx 9722 12 dizygotic dizygotic JJ cord-010092-uftc8inx 9722 13 sister sister NN cord-010092-uftc8inx 9722 14 ) ) -RRB- cord-010092-uftc8inx 9722 15 had have VBD cord-010092-uftc8inx 9722 16 regular regular JJ cord-010092-uftc8inx 9722 17 ABO ABO NNP cord-010092-uftc8inx 9722 18 blood blood NN cord-010092-uftc8inx 9722 19 types type NNS cord-010092-uftc8inx 9722 20 in in IN cord-010092-uftc8inx 9722 21 the the DT cord-010092-uftc8inx 9722 22 serologic serologic NNP cord-010092-uftc8inx 9722 23 test test NN cord-010092-uftc8inx 9722 24 . . . cord-010092-uftc8inx 9723 1 We -PRON- PRP cord-010092-uftc8inx 9723 2 performed perform VBD cord-010092-uftc8inx 9723 3 STR STR NNP cord-010092-uftc8inx 9723 4 analysis analysis NN cord-010092-uftc8inx 9723 5 in in IN cord-010092-uftc8inx 9723 6 the the DT cord-010092-uftc8inx 9723 7 triplets triplet NNS cord-010092-uftc8inx 9723 8 and and CC cord-010092-uftc8inx 9723 9 parents parent NNS cord-010092-uftc8inx 9723 10 . . . cord-010092-uftc8inx 9724 1 Eleven eleven CD cord-010092-uftc8inx 9724 2 loci locus NNS cord-010092-uftc8inx 9724 3 ( ( -LRB- cord-010092-uftc8inx 9724 4 D8S1179 D8S1179 NNP cord-010092-uftc8inx 9724 5 , , , cord-010092-uftc8inx 9724 6 D21S11 D21S11 NNP cord-010092-uftc8inx 9724 7 , , , cord-010092-uftc8inx 9724 8 D7S820 d7s820 NN cord-010092-uftc8inx 9724 9 , , , cord-010092-uftc8inx 9724 10 CSF1PO CSF1PO NNP cord-010092-uftc8inx 9724 11 , , , cord-010092-uftc8inx 9724 12 TH01 TH01 NNP cord-010092-uftc8inx 9724 13 , , , cord-010092-uftc8inx 9724 14 D13S317 D13S317 NNP cord-010092-uftc8inx 9724 15 , , , cord-010092-uftc8inx 9724 16 D16S539 D16S539 NNP cord-010092-uftc8inx 9724 17 , , , cord-010092-uftc8inx 9724 18 D19S433 D19S433 NNP cord-010092-uftc8inx 9724 19 , , , cord-010092-uftc8inx 9724 20 D18S51 D18S51 NNP cord-010092-uftc8inx 9724 21 , , , cord-010092-uftc8inx 9724 22 D5S818 D5S818 NNS cord-010092-uftc8inx 9724 23 , , , cord-010092-uftc8inx 9724 24 and and CC cord-010092-uftc8inx 9724 25 FGA FGA NNP cord-010092-uftc8inx 9724 26 ) ) -RRB- cord-010092-uftc8inx 9724 27 revealed reveal VBD cord-010092-uftc8inx 9724 28 more more JJR cord-010092-uftc8inx 9724 29 than than IN cord-010092-uftc8inx 9724 30 one one CD cord-010092-uftc8inx 9724 31 additional additional JJ cord-010092-uftc8inx 9724 32 allele allele NN cord-010092-uftc8inx 9724 33 in in IN cord-010092-uftc8inx 9724 34 the the DT cord-010092-uftc8inx 9724 35 blood blood NN cord-010092-uftc8inx 9724 36 sample sample NN cord-010092-uftc8inx 9724 37 , , , cord-010092-uftc8inx 9724 38 apart apart RB cord-010092-uftc8inx 9724 39 from from IN cord-010092-uftc8inx 9724 40 those those DT cord-010092-uftc8inx 9724 41 in in IN cord-010092-uftc8inx 9724 42 the the DT cord-010092-uftc8inx 9724 43 buccal buccal JJ cord-010092-uftc8inx 9724 44 swabs swab NNS cord-010092-uftc8inx 9724 45 . . . cord-010092-uftc8inx 9725 1 STR STR NNP cord-010092-uftc8inx 9725 2 marker marker NN cord-010092-uftc8inx 9725 3 analysis analysis NN cord-010092-uftc8inx 9725 4 showed show VBD cord-010092-uftc8inx 9725 5 that that IN cord-010092-uftc8inx 9725 6 his -PRON- PRP$ cord-010092-uftc8inx 9725 7 brother brother NN cord-010092-uftc8inx 9725 8 too too RB cord-010092-uftc8inx 9725 9 had have VBD cord-010092-uftc8inx 9725 10 blood blood NN cord-010092-uftc8inx 9725 11 chimerism chimerism NN cord-010092-uftc8inx 9725 12 . . . cord-010092-uftc8inx 9726 1 Summary Summary NNP cord-010092-uftc8inx 9726 2 / / SYM cord-010092-uftc8inx 9726 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 9726 4 : : : cord-010092-uftc8inx 9727 1 We -PRON- PRP cord-010092-uftc8inx 9727 2 found find VBD cord-010092-uftc8inx 9727 3 blood blood NN cord-010092-uftc8inx 9727 4 chimerism chimerism NN cord-010092-uftc8inx 9727 5 in in IN cord-010092-uftc8inx 9727 6 monochorionic monochorionic JJ cord-010092-uftc8inx 9727 7 dizygotic dizygotic JJ cord-010092-uftc8inx 9727 8 twins twin NNS cord-010092-uftc8inx 9727 9 of of IN cord-010092-uftc8inx 9727 10 triplets triplet NNS cord-010092-uftc8inx 9727 11 during during IN cord-010092-uftc8inx 9727 12 routine routine JJ cord-010092-uftc8inx 9727 13 ABO ABO NNP cord-010092-uftc8inx 9727 14 blood blood NN cord-010092-uftc8inx 9727 15 typing typing NN cord-010092-uftc8inx 9727 16 , , , cord-010092-uftc8inx 9727 17 and and CC cord-010092-uftc8inx 9727 18 this this DT cord-010092-uftc8inx 9727 19 was be VBD cord-010092-uftc8inx 9727 20 confirmed confirm VBN cord-010092-uftc8inx 9727 21 by by IN cord-010092-uftc8inx 9727 22 STR STR NNP cord-010092-uftc8inx 9727 23 analysis analysis NN cord-010092-uftc8inx 9727 24 . . . cord-010092-uftc8inx 9728 1 As as IN cord-010092-uftc8inx 9728 2 the the DT cord-010092-uftc8inx 9728 3 application application NN cord-010092-uftc8inx 9728 4 of of IN cord-010092-uftc8inx 9728 5 assisted assisted JJ cord-010092-uftc8inx 9728 6 reproductive reproductive JJ cord-010092-uftc8inx 9728 7 technology technology NN cord-010092-uftc8inx 9728 8 increases increase NNS cord-010092-uftc8inx 9728 9 , , , cord-010092-uftc8inx 9728 10 the the DT cord-010092-uftc8inx 9728 11 incidence incidence NN cord-010092-uftc8inx 9728 12 of of IN cord-010092-uftc8inx 9728 13 blood blood NN cord-010092-uftc8inx 9728 14 chimerism chimerism NN cord-010092-uftc8inx 9728 15 will will MD cord-010092-uftc8inx 9728 16 also also RB cord-010092-uftc8inx 9728 17 increase increase VB cord-010092-uftc8inx 9728 18 . . . cord-010092-uftc8inx 9729 1 Blood blood NN cord-010092-uftc8inx 9729 2 chimerism chimerism NN cord-010092-uftc8inx 9729 3 can can MD cord-010092-uftc8inx 9729 4 often often RB cord-010092-uftc8inx 9729 5 create create VB cord-010092-uftc8inx 9729 6 confusion confusion NN cord-010092-uftc8inx 9729 7 during during IN cord-010092-uftc8inx 9729 8 ABO ABO NNP cord-010092-uftc8inx 9729 9 serologic serologic NN cord-010092-uftc8inx 9729 10 typing typing NN cord-010092-uftc8inx 9729 11 and and CC cord-010092-uftc8inx 9729 12 microchimerism microchimerism NN cord-010092-uftc8inx 9729 13 can can MD cord-010092-uftc8inx 9729 14 be be VB cord-010092-uftc8inx 9729 15 overlooked overlook VBN cord-010092-uftc8inx 9729 16 in in IN cord-010092-uftc8inx 9729 17 routine routine JJ cord-010092-uftc8inx 9729 18 methods method NNS cord-010092-uftc8inx 9729 19 . . . cord-010092-uftc8inx 9730 1 Therefore therefore RB cord-010092-uftc8inx 9730 2 , , , cord-010092-uftc8inx 9730 3 it -PRON- PRP cord-010092-uftc8inx 9730 4 is be VBZ cord-010092-uftc8inx 9730 5 helpful helpful JJ cord-010092-uftc8inx 9730 6 to to TO cord-010092-uftc8inx 9730 7 use use VB cord-010092-uftc8inx 9730 8 an an DT cord-010092-uftc8inx 9730 9 automated automate VBN cord-010092-uftc8inx 9730 10 blood blood NN cord-010092-uftc8inx 9730 11 bank bank NN cord-010092-uftc8inx 9730 12 system system NN cord-010092-uftc8inx 9730 13 to to TO cord-010092-uftc8inx 9730 14 improve improve VB cord-010092-uftc8inx 9730 15 sensitivity sensitivity NN cord-010092-uftc8inx 9730 16 and and CC cord-010092-uftc8inx 9730 17 blood blood NN cord-010092-uftc8inx 9730 18 chimerism chimerism NN cord-010092-uftc8inx 9730 19 should should MD cord-010092-uftc8inx 9730 20 be be VB cord-010092-uftc8inx 9730 21 considered consider VBN cord-010092-uftc8inx 9730 22 if if IN cord-010092-uftc8inx 9730 23 ABO ABO NNP cord-010092-uftc8inx 9730 24 blood blood NN cord-010092-uftc8inx 9730 25 grouping grouping NN cord-010092-uftc8inx 9730 26 reveals reveal VBZ cord-010092-uftc8inx 9730 27 double double JJ cord-010092-uftc8inx 9730 28 populations population NNS cord-010092-uftc8inx 9730 29 . . . cord-010092-uftc8inx 9731 1 Background background NN cord-010092-uftc8inx 9731 2 : : : cord-010092-uftc8inx 9732 1 Expression expression NN cord-010092-uftc8inx 9732 2 of of IN cord-010092-uftc8inx 9732 3 ABO ABO NNP cord-010092-uftc8inx 9732 4 transferase transferase NN cord-010092-uftc8inx 9732 5 genes gene NNS cord-010092-uftc8inx 9732 6 can can MD cord-010092-uftc8inx 9732 7 be be VB cord-010092-uftc8inx 9732 8 affected affect VBN cord-010092-uftc8inx 9732 9 by by IN cord-010092-uftc8inx 9732 10 genetic genetic JJ cord-010092-uftc8inx 9732 11 variants variant NNS cord-010092-uftc8inx 9732 12 located locate VBN cord-010092-uftc8inx 9732 13 within within IN cord-010092-uftc8inx 9732 14 the the DT cord-010092-uftc8inx 9732 15 coding coding NN cord-010092-uftc8inx 9732 16 sequence sequence NN cord-010092-uftc8inx 9732 17 , , , cord-010092-uftc8inx 9732 18 at at IN cord-010092-uftc8inx 9732 19 splice splice NN cord-010092-uftc8inx 9732 20 junctions junction NNS cord-010092-uftc8inx 9732 21 , , , cord-010092-uftc8inx 9732 22 in in IN cord-010092-uftc8inx 9732 23 the the DT cord-010092-uftc8inx 9732 24 proximal proximal JJ cord-010092-uftc8inx 9732 25 promoter promoter NN cord-010092-uftc8inx 9732 26 and and CC cord-010092-uftc8inx 9732 27 in in IN cord-010092-uftc8inx 9732 28 the the DT cord-010092-uftc8inx 9732 29 intron intron NN cord-010092-uftc8inx 9732 30 1 1 CD cord-010092-uftc8inx 9732 31 enhancer enhancer NN cord-010092-uftc8inx 9732 32 . . . cord-010092-uftc8inx 9733 1 Here here RB cord-010092-uftc8inx 9733 2 we -PRON- PRP cord-010092-uftc8inx 9733 3 describe describe VBP cord-010092-uftc8inx 9733 4 five five CD cord-010092-uftc8inx 9733 5 new new JJ cord-010092-uftc8inx 9733 6 alleles allele NNS cord-010092-uftc8inx 9733 7 with with IN cord-010092-uftc8inx 9733 8 singlenucleotide singlenucleotide NN cord-010092-uftc8inx 9733 9 substitutions substitution NNS cord-010092-uftc8inx 9733 10 found find VBN cord-010092-uftc8inx 9733 11 in in IN cord-010092-uftc8inx 9733 12 samples sample NNS cord-010092-uftc8inx 9733 13 with with IN cord-010092-uftc8inx 9733 14 discrepant discrepant JJ cord-010092-uftc8inx 9733 15 or or CC cord-010092-uftc8inx 9733 16 unusual unusual JJ cord-010092-uftc8inx 9733 17 ABO ABO NNP cord-010092-uftc8inx 9733 18 serology serology NN cord-010092-uftc8inx 9733 19 . . . cord-010092-uftc8inx 9734 1 Aims aim VBZ cord-010092-uftc8inx 9734 2 : : : cord-010092-uftc8inx 9735 1 To to TO cord-010092-uftc8inx 9735 2 resolve resolve VB cord-010092-uftc8inx 9735 3 serological serological JJ cord-010092-uftc8inx 9735 4 discrepancies discrepancy NNS cord-010092-uftc8inx 9735 5 or or CC cord-010092-uftc8inx 9735 6 unusual unusual JJ cord-010092-uftc8inx 9735 7 serological serological JJ cord-010092-uftc8inx 9735 8 findings finding NNS cord-010092-uftc8inx 9735 9 in in IN cord-010092-uftc8inx 9735 10 the the DT cord-010092-uftc8inx 9735 11 ABO ABO NNP cord-010092-uftc8inx 9735 12 blood blood NN cord-010092-uftc8inx 9735 13 group group NN cord-010092-uftc8inx 9735 14 system system NN cord-010092-uftc8inx 9735 15 by by IN cord-010092-uftc8inx 9735 16 molecular molecular JJ cord-010092-uftc8inx 9735 17 methods method NNS cord-010092-uftc8inx 9735 18 , , , cord-010092-uftc8inx 9735 19 in in IN cord-010092-uftc8inx 9735 20 particular particular JJ cord-010092-uftc8inx 9735 21 by by IN cord-010092-uftc8inx 9735 22 Sanger Sanger NNP cord-010092-uftc8inx 9735 23 sequencing sequencing NN cord-010092-uftc8inx 9735 24 . . . cord-010092-uftc8inx 9736 1 Methods method NNS cord-010092-uftc8inx 9736 2 : : : cord-010092-uftc8inx 9737 1 Forward forward RB cord-010092-uftc8inx 9737 2 and and CC cord-010092-uftc8inx 9737 3 reverse reverse VB cord-010092-uftc8inx 9737 4 ABO ABO NNP cord-010092-uftc8inx 9737 5 phenotyping phenotyping NN cord-010092-uftc8inx 9737 6 was be VBD cord-010092-uftc8inx 9737 7 performed perform VBN cord-010092-uftc8inx 9737 8 by by IN cord-010092-uftc8inx 9737 9 the the DT cord-010092-uftc8inx 9737 10 gel gel NN cord-010092-uftc8inx 9737 11 or or CC cord-010092-uftc8inx 9737 12 tube tube NN cord-010092-uftc8inx 9737 13 methods method NNS cord-010092-uftc8inx 9737 14 . . . cord-010092-uftc8inx 9738 1 Genomic genomic JJ cord-010092-uftc8inx 9738 2 DNA dna NN cord-010092-uftc8inx 9738 3 extracted extract VBN cord-010092-uftc8inx 9738 4 from from IN cord-010092-uftc8inx 9738 5 whole whole JJ cord-010092-uftc8inx 9738 6 blood blood NN cord-010092-uftc8inx 9738 7 was be VBD cord-010092-uftc8inx 9738 8 PCR PCR NNP cord-010092-uftc8inx 9738 9 amplified amplify VBN cord-010092-uftc8inx 9738 10 to to TO cord-010092-uftc8inx 9738 11 cover cover VB cord-010092-uftc8inx 9738 12 the the DT cord-010092-uftc8inx 9738 13 entire entire JJ cord-010092-uftc8inx 9738 14 ABO ABO NNP cord-010092-uftc8inx 9738 15 coding coding NN cord-010092-uftc8inx 9738 16 sequence sequence NN cord-010092-uftc8inx 9738 17 , , , cord-010092-uftc8inx 9738 18 splice splice NN cord-010092-uftc8inx 9738 19 junctions junction NNS cord-010092-uftc8inx 9738 20 , , , cord-010092-uftc8inx 9738 21 proximal proximal JJ cord-010092-uftc8inx 9738 22 promoter promoter NN cord-010092-uftc8inx 9738 23 and and CC cord-010092-uftc8inx 9738 24 intron intron NN cord-010092-uftc8inx 9738 25 1 1 CD cord-010092-uftc8inx 9738 26 enhancer enhancer NN cord-010092-uftc8inx 9738 27 . . . cord-010092-uftc8inx 9739 1 Amplification amplification NN cord-010092-uftc8inx 9739 2 products product NNS cord-010092-uftc8inx 9739 3 were be VBD cord-010092-uftc8inx 9739 4 Sanger Sanger NNP cord-010092-uftc8inx 9739 5 sequenced sequence VBN cord-010092-uftc8inx 9739 6 directly directly RB cord-010092-uftc8inx 9739 7 or or CC cord-010092-uftc8inx 9739 8 after after IN cord-010092-uftc8inx 9739 9 cloning clone VBG cord-010092-uftc8inx 9739 10 in in IN cord-010092-uftc8inx 9739 11 a a DT cord-010092-uftc8inx 9739 12 bacterial bacterial JJ cord-010092-uftc8inx 9739 13 host host NN cord-010092-uftc8inx 9739 14 . . . cord-010092-uftc8inx 9740 1 Results result NNS cord-010092-uftc8inx 9740 2 : : : cord-010092-uftc8inx 9741 1 Case case NN cord-010092-uftc8inx 9741 2 # # NN cord-010092-uftc8inx 9741 3 1 1 CD cord-010092-uftc8inx 9741 4 is be VBZ cord-010092-uftc8inx 9741 5 a a DT cord-010092-uftc8inx 9741 6 patient patient NN cord-010092-uftc8inx 9741 7 with with IN cord-010092-uftc8inx 9741 8 an an DT cord-010092-uftc8inx 9741 9 unclear unclear JJ cord-010092-uftc8inx 9741 10 ABO ABO NNP cord-010092-uftc8inx 9741 11 phenotype phenotype NN cord-010092-uftc8inx 9741 12 : : : cord-010092-uftc8inx 9742 1 Forward forward JJ cord-010092-uftc8inx 9742 2 type type NN cord-010092-uftc8inx 9742 3 B b NN cord-010092-uftc8inx 9742 4 , , , cord-010092-uftc8inx 9742 5 reverse reverse JJ cord-010092-uftc8inx 9742 6 type type NN cord-010092-uftc8inx 9742 7 AB ab NN cord-010092-uftc8inx 9742 8 . . . cord-010092-uftc8inx 9743 1 Sequencing sequencing NN cord-010092-uftc8inx 9743 2 of of IN cord-010092-uftc8inx 9743 3 genomic genomic JJ cord-010092-uftc8inx 9743 4 DNA dna NN cord-010092-uftc8inx 9743 5 and and CC cord-010092-uftc8inx 9743 6 cloned clone VBD cord-010092-uftc8inx 9743 7 ABO ABO NNP cord-010092-uftc8inx 9743 8 exon exon NN cord-010092-uftc8inx 9743 9 7 7 CD cord-010092-uftc8inx 9743 10 detected detected JJ cord-010092-uftc8inx 9743 11 variant variant JJ cord-010092-uftc8inx 9743 12 c.29 c.29 NN cord-010092-uftc8inx 9743 13 - - HYPH cord-010092-uftc8inx 9743 14 5 5 CD cord-010092-uftc8inx 9743 15 T t NN cord-010092-uftc8inx 9744 1 > > XX cord-010092-uftc8inx 9745 1 G g NN cord-010092-uftc8inx 9745 2 in in IN cord-010092-uftc8inx 9745 3 heterozygosity heterozygosity NN cord-010092-uftc8inx 9745 4 on on IN cord-010092-uftc8inx 9745 5 an an DT cord-010092-uftc8inx 9745 6 otherwise otherwise RB cord-010092-uftc8inx 9745 7 common common JJ cord-010092-uftc8inx 9745 8 A1 A1 NNP cord-010092-uftc8inx 9745 9 allele allele NN cord-010092-uftc8inx 9745 10 , , , cord-010092-uftc8inx 9745 11 and and CC cord-010092-uftc8inx 9745 12 in in IN cord-010092-uftc8inx 9745 13 trans trans NNP cord-010092-uftc8inx 9745 14 an an DT cord-010092-uftc8inx 9745 15 ABO*B.01 abo*b.01 JJ cord-010092-uftc8inx 9745 16 allele allele NN cord-010092-uftc8inx 9745 17 . . . cord-010092-uftc8inx 9746 1 Case case NN cord-010092-uftc8inx 9746 2 # # $ cord-010092-uftc8inx 9746 3 2 2 CD cord-010092-uftc8inx 9746 4 is be VBZ cord-010092-uftc8inx 9746 5 a a DT cord-010092-uftc8inx 9746 6 caucasian caucasian JJ cord-010092-uftc8inx 9746 7 donor donor NN cord-010092-uftc8inx 9746 8 with with IN cord-010092-uftc8inx 9746 9 an an DT cord-010092-uftc8inx 9746 10 ABO ABO NNP cord-010092-uftc8inx 9746 11 discrepancy discrepancy NN cord-010092-uftc8inx 9746 12 : : : cord-010092-uftc8inx 9746 13 Forward forward JJ cord-010092-uftc8inx 9746 14 type type NN cord-010092-uftc8inx 9746 15 Aweak Aweak NNP cord-010092-uftc8inx 9746 16 / / SYM cord-010092-uftc8inx 9746 17 O o UH cord-010092-uftc8inx 9746 18 , , , cord-010092-uftc8inx 9746 19 reverse reverse JJ cord-010092-uftc8inx 9746 20 type type NN cord-010092-uftc8inx 9746 21 A. a. NN cord-010092-uftc8inx 9746 22 Sequencing Sequencing NNP cord-010092-uftc8inx 9746 23 also also RB cord-010092-uftc8inx 9746 24 detected detect VBD cord-010092-uftc8inx 9746 25 variant variant JJ cord-010092-uftc8inx 9746 26 c.29 c.29 NN cord-010092-uftc8inx 9746 27 - - HYPH cord-010092-uftc8inx 9746 28 5 5 CD cord-010092-uftc8inx 9746 29 T t NN cord-010092-uftc8inx 9747 1 > > XX cord-010092-uftc8inx 9748 1 G g NN cord-010092-uftc8inx 9748 2 in in IN cord-010092-uftc8inx 9748 3 heterozygosity heterozygosity NN cord-010092-uftc8inx 9748 4 on on IN cord-010092-uftc8inx 9748 5 an an DT cord-010092-uftc8inx 9748 6 A A NNP cord-010092-uftc8inx 9748 7 background background NN cord-010092-uftc8inx 9748 8 , , , cord-010092-uftc8inx 9748 9 and and CC cord-010092-uftc8inx 9748 10 in in IN cord-010092-uftc8inx 9748 11 trans trans NNP cord-010092-uftc8inx 9748 12 an an DT cord-010092-uftc8inx 9748 13 ABO*O.01.01 ABO*O.01.01 NNP cord-010092-uftc8inx 9748 14 allele allele NN cord-010092-uftc8inx 9748 15 . . . cord-010092-uftc8inx 9749 1 Given give VBN cord-010092-uftc8inx 9749 2 that that IN cord-010092-uftc8inx 9749 3 this this DT cord-010092-uftc8inx 9749 4 variant variant NN cord-010092-uftc8inx 9749 5 is be VBZ cord-010092-uftc8inx 9749 6 located locate VBN cord-010092-uftc8inx 9749 7 near near IN cord-010092-uftc8inx 9749 8 the the DT cord-010092-uftc8inx 9749 9 intron intron NN cord-010092-uftc8inx 9749 10 1 1 CD cord-010092-uftc8inx 9749 11 splice splice NN cord-010092-uftc8inx 9749 12 acceptor acceptor NN cord-010092-uftc8inx 9749 13 site site NN cord-010092-uftc8inx 9749 14 , , , cord-010092-uftc8inx 9749 15 ABO*29 abo*29 NN cord-010092-uftc8inx 9749 16 - - SYM cord-010092-uftc8inx 9749 17 5 5 CD cord-010092-uftc8inx 9749 18 G g NN cord-010092-uftc8inx 9749 19 transcripts transcript NNS cord-010092-uftc8inx 9749 20 are be VBP cord-010092-uftc8inx 9749 21 postulated postulate VBN cord-010092-uftc8inx 9749 22 to to TO cord-010092-uftc8inx 9749 23 undergo undergo VB cord-010092-uftc8inx 9749 24 altered alter VBN cord-010092-uftc8inx 9749 25 splicing splicing NN cord-010092-uftc8inx 9749 26 , , , cord-010092-uftc8inx 9749 27 leading lead VBG cord-010092-uftc8inx 9749 28 to to IN cord-010092-uftc8inx 9749 29 an an DT cord-010092-uftc8inx 9749 30 Aweak Aweak NNP cord-010092-uftc8inx 9749 31 phenotype phenotype NN cord-010092-uftc8inx 9749 32 . . . cord-010092-uftc8inx 9750 1 Case case NN cord-010092-uftc8inx 9750 2 # # NN cord-010092-uftc8inx 9750 3 3 3 CD cord-010092-uftc8inx 9750 4 is be VBZ cord-010092-uftc8inx 9750 5 a a DT cord-010092-uftc8inx 9750 6 prenatal prenatal JJ cord-010092-uftc8inx 9750 7 sickle sickle NN cord-010092-uftc8inx 9750 8 - - HYPH cord-010092-uftc8inx 9750 9 cell cell NN cord-010092-uftc8inx 9750 10 disease disease NN cord-010092-uftc8inx 9750 11 patient patient JJ cord-010092-uftc8inx 9750 12 with with IN cord-010092-uftc8inx 9750 13 an an DT cord-010092-uftc8inx 9750 14 ABO ABO NNP cord-010092-uftc8inx 9750 15 discrepancy discrepancy NN cord-010092-uftc8inx 9750 16 : : : cord-010092-uftc8inx 9750 17 Forward Forward NNP cord-010092-uftc8inx 9750 18 type type NN cord-010092-uftc8inx 9750 19 Aweak Aweak NNP cord-010092-uftc8inx 9750 20 , , , cord-010092-uftc8inx 9750 21 reverse reverse VB cord-010092-uftc8inx 9751 1 type type NN cord-010092-uftc8inx 9751 2 A. a. NN cord-010092-uftc8inx 9751 3 DNA dna NN cord-010092-uftc8inx 9751 4 sequencing sequencing NN cord-010092-uftc8inx 9751 5 detected detect VBN cord-010092-uftc8inx 9751 6 variants variant NNS cord-010092-uftc8inx 9751 7 c.467C c.467c XX cord-010092-uftc8inx 9752 1 > > XX cord-010092-uftc8inx 9752 2 T T NNP cord-010092-uftc8inx 9752 3 ( ( -LRB- cord-010092-uftc8inx 9752 4 Pro156Leu Pro156Leu NNP cord-010092-uftc8inx 9752 5 ) ) -RRB- cord-010092-uftc8inx 9752 6 and and CC cord-010092-uftc8inx 9752 7 c.709 c.709 NNP cord-010092-uftc8inx 9752 8 T t NN cord-010092-uftc8inx 9752 9 > > XX cord-010092-uftc8inx 9753 1 A a DT cord-010092-uftc8inx 9753 2 ( ( -LRB- cord-010092-uftc8inx 9753 3 Tyr237Asn tyr237asn NN cord-010092-uftc8inx 9753 4 ) ) -RRB- cord-010092-uftc8inx 9753 5 , , , cord-010092-uftc8inx 9753 6 both both CC cord-010092-uftc8inx 9753 7 in in IN cord-010092-uftc8inx 9753 8 heterozygosity heterozygosity NN cord-010092-uftc8inx 9753 9 on on IN cord-010092-uftc8inx 9753 10 an an DT cord-010092-uftc8inx 9753 11 otherwise otherwise RB cord-010092-uftc8inx 9753 12 common common JJ cord-010092-uftc8inx 9753 13 A1 A1 NNP cord-010092-uftc8inx 9753 14 allele allele NN cord-010092-uftc8inx 9753 15 , , , cord-010092-uftc8inx 9753 16 with with IN cord-010092-uftc8inx 9753 17 an an DT cord-010092-uftc8inx 9753 18 ABO*O.01.01 ABO*O.01.01 NNP cord-010092-uftc8inx 9753 19 allele allele NN cord-010092-uftc8inx 9753 20 in in IN cord-010092-uftc8inx 9753 21 trans trans NNP cord-010092-uftc8inx 9753 22 . . . cord-010092-uftc8inx 9754 1 Thus thus RB cord-010092-uftc8inx 9754 2 , , , cord-010092-uftc8inx 9754 3 the the DT cord-010092-uftc8inx 9754 4 data datum NNS cord-010092-uftc8inx 9754 5 establish establish VBP cord-010092-uftc8inx 9754 6 an an DT cord-010092-uftc8inx 9754 7 association association NN cord-010092-uftc8inx 9754 8 of of IN cord-010092-uftc8inx 9754 9 allele allele NN cord-010092-uftc8inx 9754 10 ABO*467T,709A ABO*467T,709A NNP cord-010092-uftc8inx 9754 11 with with IN cord-010092-uftc8inx 9754 12 an an DT cord-010092-uftc8inx 9754 13 Aweak Aweak NNP cord-010092-uftc8inx 9754 14 - - HYPH cord-010092-uftc8inx 9754 15 like like JJ cord-010092-uftc8inx 9754 16 phenotype phenotype NN cord-010092-uftc8inx 9754 17 . . . cord-010092-uftc8inx 9755 1 Case case NN cord-010092-uftc8inx 9755 2 # # NN cord-010092-uftc8inx 9755 3 4 4 CD cord-010092-uftc8inx 9755 4 is be VBZ cord-010092-uftc8inx 9755 5 a a DT cord-010092-uftc8inx 9755 6 donor donor NN cord-010092-uftc8inx 9755 7 with with IN cord-010092-uftc8inx 9755 8 an an DT cord-010092-uftc8inx 9755 9 ABO ABO NNP cord-010092-uftc8inx 9755 10 typing typing NN cord-010092-uftc8inx 9755 11 discrepancy discrepancy NN cord-010092-uftc8inx 9755 12 : : : cord-010092-uftc8inx 9756 1 Forward forward JJ cord-010092-uftc8inx 9756 2 type type NN cord-010092-uftc8inx 9756 3 O o NN cord-010092-uftc8inx 9756 4 , , , cord-010092-uftc8inx 9756 5 reverse reverse JJ cord-010092-uftc8inx 9756 6 type type NN cord-010092-uftc8inx 9756 7 A. a. NN cord-010092-uftc8inx 9756 8 Sequencing Sequencing NNP cord-010092-uftc8inx 9756 9 detected detect VBD cord-010092-uftc8inx 9756 10 variant variant NN cord-010092-uftc8inx 9756 11 c.479C c.479c NN cord-010092-uftc8inx 9757 1 > > XX cord-010092-uftc8inx 9758 1 G G NNP cord-010092-uftc8inx 9758 2 ( ( -LRB- cord-010092-uftc8inx 9758 3 Pro160Arg Pro160Arg NNP cord-010092-uftc8inx 9758 4 ) ) -RRB- cord-010092-uftc8inx 9758 5 in in IN cord-010092-uftc8inx 9758 6 heterozygosity heterozygosity NN cord-010092-uftc8inx 9758 7 on on IN cord-010092-uftc8inx 9758 8 an an DT cord-010092-uftc8inx 9758 9 A2 A2 NNP cord-010092-uftc8inx 9758 10 background background NN cord-010092-uftc8inx 9758 11 , , , cord-010092-uftc8inx 9758 12 and and CC cord-010092-uftc8inx 9758 13 in in IN cord-010092-uftc8inx 9758 14 trans trans NNP cord-010092-uftc8inx 9758 15 an an DT cord-010092-uftc8inx 9758 16 ABO*O.01 abo*o.01 JJ cord-010092-uftc8inx 9758 17 allele allele NN cord-010092-uftc8inx 9758 18 . . . cord-010092-uftc8inx 9759 1 An an DT cord-010092-uftc8inx 9759 2 interpretation interpretation NN cord-010092-uftc8inx 9759 3 of of IN cord-010092-uftc8inx 9759 4 the the DT cord-010092-uftc8inx 9759 5 data data NN cord-010092-uftc8inx 9759 6 is be VBZ cord-010092-uftc8inx 9759 7 that that DT cord-010092-uftc8inx 9759 8 variant variant NN cord-010092-uftc8inx 9759 9 c.479C c.479c NN cord-010092-uftc8inx 9760 1 > > XX cord-010092-uftc8inx 9761 1 G g NN cord-010092-uftc8inx 9761 2 weakens weaken VBZ cord-010092-uftc8inx 9761 3 the the DT cord-010092-uftc8inx 9761 4 activity activity NN cord-010092-uftc8inx 9761 5 of of IN cord-010092-uftc8inx 9761 6 the the DT cord-010092-uftc8inx 9761 7 A2 A2 NNP cord-010092-uftc8inx 9761 8 transferase transferase NN cord-010092-uftc8inx 9761 9 , , , cord-010092-uftc8inx 9761 10 with with IN cord-010092-uftc8inx 9761 11 allele allele NN cord-010092-uftc8inx 9761 12 ABO*A2(479 ABO*A2(479 NNP cord-010092-uftc8inx 9761 13 G G NNP cord-010092-uftc8inx 9761 14 ) ) -RRB- cord-010092-uftc8inx 9761 15 encoding encode VBG cord-010092-uftc8inx 9761 16 the the DT cord-010092-uftc8inx 9761 17 Aweak Aweak NNP cord-010092-uftc8inx 9761 18 - - HYPH cord-010092-uftc8inx 9761 19 like like JJ cord-010092-uftc8inx 9761 20 phenotype phenotype NN cord-010092-uftc8inx 9761 21 detected detect VBN cord-010092-uftc8inx 9761 22 by by IN cord-010092-uftc8inx 9761 23 serology serology NN cord-010092-uftc8inx 9761 24 . . . cord-010092-uftc8inx 9762 1 Case case NN cord-010092-uftc8inx 9762 2 # # NN cord-010092-uftc8inx 9762 3 5 5 CD cord-010092-uftc8inx 9762 4 is be VBZ cord-010092-uftc8inx 9762 5 a a DT cord-010092-uftc8inx 9762 6 9 9 CD cord-010092-uftc8inx 9762 7 year year NN cord-010092-uftc8inx 9762 8 - - HYPH cord-010092-uftc8inx 9762 9 old old JJ cord-010092-uftc8inx 9762 10 patient patient NN cord-010092-uftc8inx 9762 11 with with IN cord-010092-uftc8inx 9762 12 an an DT cord-010092-uftc8inx 9762 13 ABO ABO NNP cord-010092-uftc8inx 9762 14 discrepancy discrepancy NN cord-010092-uftc8inx 9762 15 : : : cord-010092-uftc8inx 9763 1 Forward forward JJ cord-010092-uftc8inx 9763 2 type type NN cord-010092-uftc8inx 9763 3 O o NN cord-010092-uftc8inx 9763 4 , , , cord-010092-uftc8inx 9763 5 reverse reverse JJ cord-010092-uftc8inx 9763 6 type type NN cord-010092-uftc8inx 9763 7 AB ab NN cord-010092-uftc8inx 9763 8 . . . cord-010092-uftc8inx 9764 1 Sequencing sequencing NN cord-010092-uftc8inx 9764 2 of of IN cord-010092-uftc8inx 9764 3 genomic genomic JJ cord-010092-uftc8inx 9764 4 DNA dna NN cord-010092-uftc8inx 9764 5 and and CC cord-010092-uftc8inx 9764 6 cloned clone VBD cord-010092-uftc8inx 9764 7 ABO ABO NNP cord-010092-uftc8inx 9764 8 exon exon NN cord-010092-uftc8inx 9764 9 7 7 CD cord-010092-uftc8inx 9764 10 detected detected JJ cord-010092-uftc8inx 9764 11 variant variant NN cord-010092-uftc8inx 9765 1 c.803 c.803 JJ cord-010092-uftc8inx 9765 2 G g NN cord-010092-uftc8inx 9765 3 > > XX cord-010092-uftc8inx 9766 1 C C NNP cord-010092-uftc8inx 9766 2 ( ( -LRB- cord-010092-uftc8inx 9766 3 Gly268Ala Gly268Ala NNP cord-010092-uftc8inx 9766 4 ) ) -RRB- cord-010092-uftc8inx 9766 5 in in IN cord-010092-uftc8inx 9766 6 heterozygosity heterozygosity NN cord-010092-uftc8inx 9766 7 on on IN cord-010092-uftc8inx 9766 8 an an DT cord-010092-uftc8inx 9766 9 A2 A2 NNP cord-010092-uftc8inx 9766 10 background background NN cord-010092-uftc8inx 9766 11 , , , cord-010092-uftc8inx 9766 12 and and CC cord-010092-uftc8inx 9766 13 in in IN cord-010092-uftc8inx 9766 14 trans trans NNP cord-010092-uftc8inx 9766 15 an an DT cord-010092-uftc8inx 9766 16 ABO*O.01.02 abo*o.01.02 JJ cord-010092-uftc8inx 9766 17 allele allele NN cord-010092-uftc8inx 9766 18 . . . cord-010092-uftc8inx 9767 1 The the DT cord-010092-uftc8inx 9767 2 serology serology NN cord-010092-uftc8inx 9767 3 and and CC cord-010092-uftc8inx 9767 4 molecular molecular JJ cord-010092-uftc8inx 9767 5 results result NNS cord-010092-uftc8inx 9767 6 suggest suggest VBP cord-010092-uftc8inx 9767 7 that that IN cord-010092-uftc8inx 9767 8 allele allele NN cord-010092-uftc8inx 9767 9 ABO*A2(803C ABO*A2(803C NNP cord-010092-uftc8inx 9767 10 ) ) -RRB- cord-010092-uftc8inx 9767 11 encodes encode VBZ cord-010092-uftc8inx 9767 12 a a DT cord-010092-uftc8inx 9767 13 cisAB cisAB VBG cord-010092-uftc8inx 9767 14 weak weak JJ cord-010092-uftc8inx 9767 15 phenotype phenotype NN cord-010092-uftc8inx 9767 16 . . . cord-010092-uftc8inx 9768 1 Case case NN cord-010092-uftc8inx 9768 2 # # $ cord-010092-uftc8inx 9768 3 6 6 CD cord-010092-uftc8inx 9768 4 is be VBZ cord-010092-uftc8inx 9768 5 a a DT cord-010092-uftc8inx 9768 6 caucasian caucasian JJ cord-010092-uftc8inx 9768 7 donor donor NN cord-010092-uftc8inx 9768 8 with with IN cord-010092-uftc8inx 9768 9 an an DT cord-010092-uftc8inx 9768 10 ABO ABO NNP cord-010092-uftc8inx 9768 11 typing typing NN cord-010092-uftc8inx 9768 12 discrepancy discrepancy NN cord-010092-uftc8inx 9768 13 : : : cord-010092-uftc8inx 9768 14 Forward forward JJ cord-010092-uftc8inx 9768 15 type type NN cord-010092-uftc8inx 9768 16 O o NN cord-010092-uftc8inx 9769 1 with with IN cord-010092-uftc8inx 9769 2 a a DT cord-010092-uftc8inx 9769 3 weak weak JJ cord-010092-uftc8inx 9769 4 agglutination agglutination NN cord-010092-uftc8inx 9769 5 with with IN cord-010092-uftc8inx 9769 6 anti anti JJ cord-010092-uftc8inx 9769 7 - - JJ cord-010092-uftc8inx 9769 8 AB ab JJ cord-010092-uftc8inx 9769 9 , , , cord-010092-uftc8inx 9769 10 reverse reverse JJ cord-010092-uftc8inx 9770 1 type type NNP cord-010092-uftc8inx 9770 2 O. O. NNP cord-010092-uftc8inx 9770 3 DNA DNA NNP cord-010092-uftc8inx 9770 4 sequencing sequencing NN cord-010092-uftc8inx 9770 5 detected detect VBN cord-010092-uftc8inx 9770 6 variants variant NNS cord-010092-uftc8inx 9771 1 c.739 c.739 NNP cord-010092-uftc8inx 9771 2 G G NNP cord-010092-uftc8inx 9772 1 > > XX cord-010092-uftc8inx 9773 1 A a LS cord-010092-uftc8inx 9773 2 ( ( -LRB- cord-010092-uftc8inx 9773 3 Glu247Lys Glu247Lys NNP cord-010092-uftc8inx 9773 4 ) ) -RRB- cord-010092-uftc8inx 9773 5 and and CC cord-010092-uftc8inx 9774 1 c.871 c.871 NNP cord-010092-uftc8inx 9774 2 G g NN cord-010092-uftc8inx 9774 3 > > XX cord-010092-uftc8inx 9775 1 A a DT cord-010092-uftc8inx 9775 2 ( ( -LRB- cord-010092-uftc8inx 9775 3 Asp291Asn Asp291Asn NNP cord-010092-uftc8inx 9775 4 ) ) -RRB- cord-010092-uftc8inx 9775 5 , , , cord-010092-uftc8inx 9775 6 both both CC cord-010092-uftc8inx 9775 7 in in IN cord-010092-uftc8inx 9775 8 heterozygosity heterozygosity NN cord-010092-uftc8inx 9775 9 , , , cord-010092-uftc8inx 9775 10 in in IN cord-010092-uftc8inx 9775 11 trans trans NNP cord-010092-uftc8inx 9775 12 , , , cord-010092-uftc8inx 9775 13 and and CC cord-010092-uftc8inx 9775 14 on on IN cord-010092-uftc8inx 9775 15 A1 A1 NNP cord-010092-uftc8inx 9775 16 backgrounds background NNS cord-010092-uftc8inx 9775 17 . . . cord-010092-uftc8inx 9776 1 Variant variant NN cord-010092-uftc8inx 9776 2 c.871 c.871 DT cord-010092-uftc8inx 9776 3 G g NN cord-010092-uftc8inx 9777 1 > > XX cord-010092-uftc8inx 9778 1 A a DT cord-010092-uftc8inx 9778 2 by by IN cord-010092-uftc8inx 9778 3 itself -PRON- PRP cord-010092-uftc8inx 9778 4 constitutes constitute VBZ cord-010092-uftc8inx 9778 5 allele allele NN cord-010092-uftc8inx 9778 6 ABO*A3.01 abo*a3.01 CD cord-010092-uftc8inx 9778 7 . . . cord-010092-uftc8inx 9779 1 The the DT cord-010092-uftc8inx 9779 2 phenotype phenotype NN cord-010092-uftc8inx 9779 3 encoded encode VBN cord-010092-uftc8inx 9779 4 by by IN cord-010092-uftc8inx 9779 5 ABO*739A ABO*739A NNP cord-010092-uftc8inx 9779 6 is be VBZ cord-010092-uftc8inx 9779 7 uncertain uncertain JJ cord-010092-uftc8inx 9779 8 . . . cord-010092-uftc8inx 9780 1 Summary Summary NNP cord-010092-uftc8inx 9780 2 / / SYM cord-010092-uftc8inx 9780 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 9780 4 : : : cord-010092-uftc8inx 9781 1 Molecular molecular JJ cord-010092-uftc8inx 9781 2 characterization characterization NN cord-010092-uftc8inx 9781 3 of of IN cord-010092-uftc8inx 9781 4 ABO ABO NNP cord-010092-uftc8inx 9781 5 alleles allele NNS cord-010092-uftc8inx 9781 6 can can MD cord-010092-uftc8inx 9781 7 help help VB cord-010092-uftc8inx 9781 8 in in IN cord-010092-uftc8inx 9781 9 their -PRON- PRP$ cord-010092-uftc8inx 9781 10 future future JJ cord-010092-uftc8inx 9781 11 identification identification NN cord-010092-uftc8inx 9781 12 and and CC cord-010092-uftc8inx 9781 13 discrepancy discrepancy NN cord-010092-uftc8inx 9781 14 resolution resolution NN cord-010092-uftc8inx 9781 15 . . . cord-010092-uftc8inx 9782 1 Background background NN cord-010092-uftc8inx 9782 2 : : : cord-010092-uftc8inx 9783 1 Expression expression NN cord-010092-uftc8inx 9783 2 of of IN cord-010092-uftc8inx 9783 3 ABO ABO NNP cord-010092-uftc8inx 9783 4 transferase transferase NN cord-010092-uftc8inx 9783 5 genes gene NNS cord-010092-uftc8inx 9783 6 can can MD cord-010092-uftc8inx 9783 7 be be VB cord-010092-uftc8inx 9783 8 affected affect VBN cord-010092-uftc8inx 9783 9 by by IN cord-010092-uftc8inx 9783 10 genetic genetic JJ cord-010092-uftc8inx 9783 11 variants variant NNS cord-010092-uftc8inx 9783 12 located locate VBN cord-010092-uftc8inx 9783 13 within within IN cord-010092-uftc8inx 9783 14 the the DT cord-010092-uftc8inx 9783 15 coding coding NN cord-010092-uftc8inx 9783 16 sequence sequence NN cord-010092-uftc8inx 9783 17 , , , cord-010092-uftc8inx 9783 18 at at IN cord-010092-uftc8inx 9783 19 splice splice NN cord-010092-uftc8inx 9783 20 junctions junction NNS cord-010092-uftc8inx 9783 21 , , , cord-010092-uftc8inx 9783 22 in in IN cord-010092-uftc8inx 9783 23 the the DT cord-010092-uftc8inx 9783 24 proximal proximal JJ cord-010092-uftc8inx 9783 25 promoter promoter NN cord-010092-uftc8inx 9783 26 and and CC cord-010092-uftc8inx 9783 27 in in IN cord-010092-uftc8inx 9783 28 the the DT cord-010092-uftc8inx 9783 29 intron intron NN cord-010092-uftc8inx 9783 30 1 1 CD cord-010092-uftc8inx 9783 31 enhancer enhancer NN cord-010092-uftc8inx 9783 32 . . . cord-010092-uftc8inx 9784 1 Here here RB cord-010092-uftc8inx 9784 2 we -PRON- PRP cord-010092-uftc8inx 9784 3 describe describe VBP cord-010092-uftc8inx 9784 4 five five CD cord-010092-uftc8inx 9784 5 new new JJ cord-010092-uftc8inx 9784 6 alleles allele NNS cord-010092-uftc8inx 9784 7 with with IN cord-010092-uftc8inx 9784 8 singlenucleotide singlenucleotide NN cord-010092-uftc8inx 9784 9 substitutions substitution NNS cord-010092-uftc8inx 9784 10 found find VBN cord-010092-uftc8inx 9784 11 in in IN cord-010092-uftc8inx 9784 12 samples sample NNS cord-010092-uftc8inx 9784 13 with with IN cord-010092-uftc8inx 9784 14 discrepant discrepant JJ cord-010092-uftc8inx 9784 15 or or CC cord-010092-uftc8inx 9784 16 unusual unusual JJ cord-010092-uftc8inx 9784 17 ABO ABO NNP cord-010092-uftc8inx 9784 18 serology serology NN cord-010092-uftc8inx 9784 19 . . . cord-010092-uftc8inx 9785 1 Aims aim VBZ cord-010092-uftc8inx 9785 2 : : : cord-010092-uftc8inx 9786 1 To to TO cord-010092-uftc8inx 9786 2 resolve resolve VB cord-010092-uftc8inx 9786 3 serological serological JJ cord-010092-uftc8inx 9786 4 discrepancies discrepancy NNS cord-010092-uftc8inx 9786 5 or or CC cord-010092-uftc8inx 9786 6 unusual unusual JJ cord-010092-uftc8inx 9786 7 serological serological JJ cord-010092-uftc8inx 9786 8 findings finding NNS cord-010092-uftc8inx 9786 9 in in IN cord-010092-uftc8inx 9786 10 the the DT cord-010092-uftc8inx 9786 11 ABO ABO NNP cord-010092-uftc8inx 9786 12 blood blood NN cord-010092-uftc8inx 9786 13 group group NN cord-010092-uftc8inx 9786 14 system system NN cord-010092-uftc8inx 9786 15 by by IN cord-010092-uftc8inx 9786 16 molecular molecular JJ cord-010092-uftc8inx 9786 17 methods method NNS cord-010092-uftc8inx 9786 18 , , , cord-010092-uftc8inx 9786 19 in in IN cord-010092-uftc8inx 9786 20 particular particular JJ cord-010092-uftc8inx 9786 21 by by IN cord-010092-uftc8inx 9786 22 Sanger Sanger NNP cord-010092-uftc8inx 9786 23 sequencing sequencing NN cord-010092-uftc8inx 9786 24 . . . cord-010092-uftc8inx 9787 1 Methods method NNS cord-010092-uftc8inx 9787 2 : : : cord-010092-uftc8inx 9788 1 Forward forward RB cord-010092-uftc8inx 9788 2 and and CC cord-010092-uftc8inx 9788 3 reverse reverse VB cord-010092-uftc8inx 9788 4 ABO ABO NNP cord-010092-uftc8inx 9788 5 phenotyping phenotyping NN cord-010092-uftc8inx 9788 6 was be VBD cord-010092-uftc8inx 9788 7 performed perform VBN cord-010092-uftc8inx 9788 8 by by IN cord-010092-uftc8inx 9788 9 the the DT cord-010092-uftc8inx 9788 10 gel gel NN cord-010092-uftc8inx 9788 11 or or CC cord-010092-uftc8inx 9788 12 tube tube NN cord-010092-uftc8inx 9788 13 methods method NNS cord-010092-uftc8inx 9788 14 . . . cord-010092-uftc8inx 9789 1 Genomic genomic JJ cord-010092-uftc8inx 9789 2 DNA dna NN cord-010092-uftc8inx 9789 3 extracted extract VBN cord-010092-uftc8inx 9789 4 from from IN cord-010092-uftc8inx 9789 5 whole whole JJ cord-010092-uftc8inx 9789 6 blood blood NN cord-010092-uftc8inx 9789 7 was be VBD cord-010092-uftc8inx 9789 8 PCR PCR NNP cord-010092-uftc8inx 9789 9 amplified amplify VBN cord-010092-uftc8inx 9789 10 to to TO cord-010092-uftc8inx 9789 11 cover cover VB cord-010092-uftc8inx 9789 12 the the DT cord-010092-uftc8inx 9789 13 entire entire JJ cord-010092-uftc8inx 9789 14 ABO ABO NNP cord-010092-uftc8inx 9789 15 coding coding NN cord-010092-uftc8inx 9789 16 sequence sequence NN cord-010092-uftc8inx 9789 17 , , , cord-010092-uftc8inx 9789 18 splice splice NN cord-010092-uftc8inx 9789 19 junctions junction NNS cord-010092-uftc8inx 9789 20 , , , cord-010092-uftc8inx 9789 21 proximal proximal JJ cord-010092-uftc8inx 9789 22 promoter promoter NN cord-010092-uftc8inx 9789 23 and and CC cord-010092-uftc8inx 9789 24 intron intron NN cord-010092-uftc8inx 9789 25 1 1 CD cord-010092-uftc8inx 9789 26 enhancer enhancer NN cord-010092-uftc8inx 9789 27 . . . cord-010092-uftc8inx 9790 1 Amplification amplification NN cord-010092-uftc8inx 9790 2 products product NNS cord-010092-uftc8inx 9790 3 were be VBD cord-010092-uftc8inx 9790 4 Sanger Sanger NNP cord-010092-uftc8inx 9790 5 sequenced sequence VBN cord-010092-uftc8inx 9790 6 directly directly RB cord-010092-uftc8inx 9790 7 or or CC cord-010092-uftc8inx 9790 8 after after IN cord-010092-uftc8inx 9790 9 cloning clone VBG cord-010092-uftc8inx 9790 10 in in IN cord-010092-uftc8inx 9790 11 a a DT cord-010092-uftc8inx 9790 12 bacterial bacterial JJ cord-010092-uftc8inx 9790 13 plasmid plasmid NN cord-010092-uftc8inx 9790 14 vector vector NN cord-010092-uftc8inx 9790 15 . . . cord-010092-uftc8inx 9791 1 Results result NNS cord-010092-uftc8inx 9791 2 : : : cord-010092-uftc8inx 9792 1 Case case NN cord-010092-uftc8inx 9792 2 # # NN cord-010092-uftc8inx 9792 3 1 1 CD cord-010092-uftc8inx 9792 4 is be VBZ cord-010092-uftc8inx 9792 5 a a DT cord-010092-uftc8inx 9792 6 35 35 CD cord-010092-uftc8inx 9792 7 year year NN cord-010092-uftc8inx 9792 8 - - HYPH cord-010092-uftc8inx 9792 9 old old JJ cord-010092-uftc8inx 9792 10 pregnant pregnant JJ cord-010092-uftc8inx 9792 11 female female NN cord-010092-uftc8inx 9792 12 with with IN cord-010092-uftc8inx 9792 13 an an DT cord-010092-uftc8inx 9792 14 ABO ABO NNP cord-010092-uftc8inx 9792 15 typing typing NN cord-010092-uftc8inx 9792 16 discrepancy discrepancy NN cord-010092-uftc8inx 9792 17 : : : cord-010092-uftc8inx 9793 1 Forward forward JJ cord-010092-uftc8inx 9793 2 type type NN cord-010092-uftc8inx 9793 3 O o NN cord-010092-uftc8inx 9793 4 , , , cord-010092-uftc8inx 9793 5 reverse reverse VB cord-010092-uftc8inx 9794 1 type type NN cord-010092-uftc8inx 9794 2 A. A. NNP cord-010092-uftc8inx 9794 3 PCR PCR NNP cord-010092-uftc8inx 9794 4 - - HYPH cord-010092-uftc8inx 9794 5 RFLP RFLP NNP cord-010092-uftc8inx 9794 6 predicted predict VBD cord-010092-uftc8inx 9794 7 ABO*A1/ abo*a1/ NN cord-010092-uftc8inx 9795 1 ABO*O1 abo*o1 NN cord-010092-uftc8inx 9795 2 . . . cord-010092-uftc8inx 9796 1 Sequencing sequencing NN cord-010092-uftc8inx 9796 2 detected detect VBD cord-010092-uftc8inx 9796 3 variant variant NN cord-010092-uftc8inx 9796 4 c.107insG c.107insg NN cord-010092-uftc8inx 9796 5 ( ( -LRB- cord-010092-uftc8inx 9796 6 Val36Gly val36gly NN cord-010092-uftc8inx 9796 7 > > XX cord-010092-uftc8inx 9796 8 fs56Ter fs56ter CD cord-010092-uftc8inx 9796 9 ) ) -RRB- cord-010092-uftc8inx 9796 10 in in IN cord-010092-uftc8inx 9796 11 heterozygosity heterozygosity NN cord-010092-uftc8inx 9796 12 on on IN cord-010092-uftc8inx 9796 13 an an DT cord-010092-uftc8inx 9796 14 otherwise otherwise RB cord-010092-uftc8inx 9796 15 common common JJ cord-010092-uftc8inx 9796 16 A1 A1 NNP cord-010092-uftc8inx 9796 17 allele allele NN cord-010092-uftc8inx 9796 18 , , , cord-010092-uftc8inx 9796 19 and and CC cord-010092-uftc8inx 9796 20 in in IN cord-010092-uftc8inx 9796 21 trans trans NNP cord-010092-uftc8inx 9796 22 an an DT cord-010092-uftc8inx 9796 23 ABO*O.01.01 ABO*O.01.01 NNP cord-010092-uftc8inx 9796 24 allele allele NN cord-010092-uftc8inx 9796 25 . . . cord-010092-uftc8inx 9797 1 It -PRON- PRP cord-010092-uftc8inx 9797 2 is be VBZ cord-010092-uftc8inx 9797 3 unclear unclear JJ cord-010092-uftc8inx 9797 4 how how WRB cord-010092-uftc8inx 9797 5 the the DT cord-010092-uftc8inx 9797 6 early early JJ cord-010092-uftc8inx 9797 7 truncation truncation NN cord-010092-uftc8inx 9797 8 of of IN cord-010092-uftc8inx 9797 9 the the DT cord-010092-uftc8inx 9797 10 A1 A1 NNP cord-010092-uftc8inx 9797 11 transferase transferase NN cord-010092-uftc8inx 9797 12 encoded encode VBN cord-010092-uftc8inx 9797 13 by by IN cord-010092-uftc8inx 9797 14 allele allele NN cord-010092-uftc8inx 9797 15 ABO*107insG ABO*107insG NNP cord-010092-uftc8inx 9797 16 still still RB cord-010092-uftc8inx 9797 17 allows allow VBZ cord-010092-uftc8inx 9797 18 for for IN cord-010092-uftc8inx 9797 19 some some DT cord-010092-uftc8inx 9797 20 residual residual JJ cord-010092-uftc8inx 9797 21 enzyme enzyme NN cord-010092-uftc8inx 9797 22 activity activity NN cord-010092-uftc8inx 9797 23 , , , cord-010092-uftc8inx 9797 24 as as IN cord-010092-uftc8inx 9797 25 suggested suggest VBN cord-010092-uftc8inx 9797 26 by by IN cord-010092-uftc8inx 9797 27 the the DT cord-010092-uftc8inx 9797 28 reverse reverse NN cord-010092-uftc8inx 9797 29 A a DT cord-010092-uftc8inx 9797 30 type type NN cord-010092-uftc8inx 9797 31 . . . cord-010092-uftc8inx 9798 1 Case case NN cord-010092-uftc8inx 9798 2 # # $ cord-010092-uftc8inx 9798 3 2 2 CD cord-010092-uftc8inx 9798 4 is be VBZ cord-010092-uftc8inx 9798 5 a a DT cord-010092-uftc8inx 9798 6 recently recently RB cord-010092-uftc8inx 9798 7 - - HYPH cord-010092-uftc8inx 9798 8 transfused transfuse VBN cord-010092-uftc8inx 9798 9 72 72 CD cord-010092-uftc8inx 9798 10 year year NN cord-010092-uftc8inx 9798 11 - - HYPH cord-010092-uftc8inx 9798 12 old old JJ cord-010092-uftc8inx 9798 13 black black JJ cord-010092-uftc8inx 9798 14 patient patient NN cord-010092-uftc8inx 9798 15 with with IN cord-010092-uftc8inx 9798 16 an an DT cord-010092-uftc8inx 9798 17 unresolved unresolved JJ cord-010092-uftc8inx 9798 18 ABO ABO NNP cord-010092-uftc8inx 9798 19 type type NN cord-010092-uftc8inx 9798 20 . . . cord-010092-uftc8inx 9799 1 Sequencing sequencing NN cord-010092-uftc8inx 9799 2 detected detect VBN cord-010092-uftc8inx 9799 3 variant variant NN cord-010092-uftc8inx 9800 1 c.297A c.297A NNP cord-010092-uftc8inx 9801 1 > > XX cord-010092-uftc8inx 9802 1 G G NNP cord-010092-uftc8inx 9802 2 ( ( -LRB- cord-010092-uftc8inx 9802 3 silent silent JJ cord-010092-uftc8inx 9802 4 ) ) -RRB- cord-010092-uftc8inx 9802 5 in in IN cord-010092-uftc8inx 9802 6 homozygosity homozygosity NN cord-010092-uftc8inx 9802 7 and and CC cord-010092-uftc8inx 9802 8 variant variant NN cord-010092-uftc8inx 9802 9 c.1049C c.1049C . cord-010092-uftc8inx 9802 10 > > XX cord-010092-uftc8inx 9802 11 T t NN cord-010092-uftc8inx 9802 12 ( ( -LRB- cord-010092-uftc8inx 9802 13 Ala350Val Ala350Val NNP cord-010092-uftc8inx 9802 14 ) ) -RRB- cord-010092-uftc8inx 9803 1 in in IN cord-010092-uftc8inx 9803 2 heterozygosity heterozygosity NN cord-010092-uftc8inx 9803 3 , , , cord-010092-uftc8inx 9803 4 both both DT cord-010092-uftc8inx 9803 5 on on IN cord-010092-uftc8inx 9803 6 an an DT cord-010092-uftc8inx 9803 7 O1 o1 NN cord-010092-uftc8inx 9803 8 background background NN cord-010092-uftc8inx 9803 9 , , , cord-010092-uftc8inx 9803 10 with with IN cord-010092-uftc8inx 9803 11 an an DT cord-010092-uftc8inx 9803 12 ABO*B.01 abo*b.01 JJ cord-010092-uftc8inx 9803 13 allele allele NN cord-010092-uftc8inx 9803 14 in in IN cord-010092-uftc8inx 9803 15 trans trans NNP cord-010092-uftc8inx 9803 16 . . . cord-010092-uftc8inx 9804 1 Although although IN cord-010092-uftc8inx 9804 2 variants variant NNS cord-010092-uftc8inx 9804 3 c.297A c.297A NNP cord-010092-uftc8inx 9805 1 > > XX cord-010092-uftc8inx 9805 2 G g NN cord-010092-uftc8inx 9805 3 and and CC cord-010092-uftc8inx 9806 1 c.1049C c.1049C NFP cord-010092-uftc8inx 9806 2 > > XX cord-010092-uftc8inx 9806 3 T T NNP cord-010092-uftc8inx 9806 4 are be VBP cord-010092-uftc8inx 9806 5 likely likely JJ cord-010092-uftc8inx 9806 6 of of IN cord-010092-uftc8inx 9806 7 no no DT cord-010092-uftc8inx 9806 8 consequence consequence NN cord-010092-uftc8inx 9806 9 to to IN cord-010092-uftc8inx 9806 10 the the DT cord-010092-uftc8inx 9806 11 ABO ABO NNP cord-010092-uftc8inx 9806 12 phenotype phenotype NN cord-010092-uftc8inx 9806 13 of of IN cord-010092-uftc8inx 9806 14 this this DT cord-010092-uftc8inx 9806 15 patient patient NN cord-010092-uftc8inx 9806 16 , , , cord-010092-uftc8inx 9806 17 they -PRON- PRP cord-010092-uftc8inx 9806 18 are be VBP cord-010092-uftc8inx 9806 19 reported report VBN cord-010092-uftc8inx 9806 20 here here RB cord-010092-uftc8inx 9806 21 as as IN cord-010092-uftc8inx 9806 22 components component NNS cord-010092-uftc8inx 9806 23 of of IN cord-010092-uftc8inx 9806 24 a a DT cord-010092-uftc8inx 9806 25 new new JJ cord-010092-uftc8inx 9806 26 ABO*O1(297G,1049 ABO*O1(297G,1049 NNP cord-010092-uftc8inx 9806 27 T T NNP cord-010092-uftc8inx 9806 28 ) ) -RRB- cord-010092-uftc8inx 9806 29 allele allele NN cord-010092-uftc8inx 9806 30 . . . cord-010092-uftc8inx 9807 1 Case case NN cord-010092-uftc8inx 9807 2 # # NN cord-010092-uftc8inx 9807 3 3 3 CD cord-010092-uftc8inx 9807 4 is be VBZ cord-010092-uftc8inx 9807 5 a a DT cord-010092-uftc8inx 9807 6 40 40 CD cord-010092-uftc8inx 9807 7 year year NN cord-010092-uftc8inx 9807 8 - - HYPH cord-010092-uftc8inx 9807 9 old old JJ cord-010092-uftc8inx 9807 10 prenatal prenatal JJ cord-010092-uftc8inx 9807 11 female female NN cord-010092-uftc8inx 9807 12 with with IN cord-010092-uftc8inx 9807 13 a a DT cord-010092-uftc8inx 9807 14 RhD rhd NN cord-010092-uftc8inx 9807 15 typing typing NN cord-010092-uftc8inx 9807 16 discrepancy discrepancy NN cord-010092-uftc8inx 9807 17 . . . cord-010092-uftc8inx 9808 1 Failure failure NN cord-010092-uftc8inx 9808 2 to to TO cord-010092-uftc8inx 9808 3 yield yield VB cord-010092-uftc8inx 9808 4 an an DT cord-010092-uftc8inx 9808 5 ABO ABO NNP cord-010092-uftc8inx 9808 6 genotype genotype NN cord-010092-uftc8inx 9808 7 on on IN cord-010092-uftc8inx 9808 8 Blood blood NN cord-010092-uftc8inx 9808 9 - - HYPH cord-010092-uftc8inx 9808 10 Chip chip NN cord-010092-uftc8inx 9808 11 ( ( -LRB- cord-010092-uftc8inx 9808 12 Progenika Progenika NNP cord-010092-uftc8inx 9808 13 ) ) -RRB- cord-010092-uftc8inx 9808 14 , , , cord-010092-uftc8inx 9808 15 a a DT cord-010092-uftc8inx 9808 16 genotyping genotyping NN cord-010092-uftc8inx 9808 17 microarray microarray NN cord-010092-uftc8inx 9808 18 that that WDT cord-010092-uftc8inx 9808 19 interrogates interrogate VBZ cord-010092-uftc8inx 9808 20 polymorphic polymorphic JJ cord-010092-uftc8inx 9808 21 positions position NNS cord-010092-uftc8inx 9808 22 in in IN cord-010092-uftc8inx 9808 23 RHD RHD NNP cord-010092-uftc8inx 9808 24 and and CC cord-010092-uftc8inx 9808 25 ABO ABO NNP cord-010092-uftc8inx 9808 26 , , , cord-010092-uftc8inx 9808 27 prompted prompt VBD cord-010092-uftc8inx 9808 28 DNA dna NN cord-010092-uftc8inx 9808 29 sequencing sequencing NN cord-010092-uftc8inx 9808 30 . . . cord-010092-uftc8inx 9809 1 Sequencing sequencing NN cord-010092-uftc8inx 9809 2 of of IN cord-010092-uftc8inx 9809 3 genomic genomic JJ cord-010092-uftc8inx 9809 4 DNA dna NN cord-010092-uftc8inx 9809 5 and and CC cord-010092-uftc8inx 9809 6 cloned clone VBD cord-010092-uftc8inx 9809 7 ABO ABO NNP cord-010092-uftc8inx 9809 8 exon exon NN cord-010092-uftc8inx 9809 9 7 7 CD cord-010092-uftc8inx 9809 10 detected detected JJ cord-010092-uftc8inx 9809 11 variant variant NN cord-010092-uftc8inx 9810 1 c.436C c.436C NNP cord-010092-uftc8inx 9811 1 > > XX cord-010092-uftc8inx 9812 1 T T NNP cord-010092-uftc8inx 9812 2 ( ( -LRB- cord-010092-uftc8inx 9812 3 Arg146Cys Arg146Cys NNP cord-010092-uftc8inx 9812 4 ) ) -RRB- cord-010092-uftc8inx 9812 5 in in IN cord-010092-uftc8inx 9812 6 heterozygosity heterozygosity NN cord-010092-uftc8inx 9812 7 on on IN cord-010092-uftc8inx 9812 8 an an DT cord-010092-uftc8inx 9812 9 ABO*B ABO*B NNP cord-010092-uftc8inx 9812 10 allele allele NN cord-010092-uftc8inx 9812 11 background background NN cord-010092-uftc8inx 9812 12 , , , cord-010092-uftc8inx 9812 13 and and CC cord-010092-uftc8inx 9812 14 in in IN cord-010092-uftc8inx 9812 15 trans trans NNP cord-010092-uftc8inx 9812 16 an an DT cord-010092-uftc8inx 9812 17 ABO*O.01.01 ABO*O.01.01 NNP cord-010092-uftc8inx 9812 18 allele allele NN cord-010092-uftc8inx 9812 19 . . . cord-010092-uftc8inx 9813 1 The the DT cord-010092-uftc8inx 9813 2 phenotype phenotype NN cord-010092-uftc8inx 9813 3 encoded encode VBN cord-010092-uftc8inx 9813 4 by by IN cord-010092-uftc8inx 9813 5 allele allele NN cord-010092-uftc8inx 9813 6 ABO*B(436 ABO*B(436 NNP cord-010092-uftc8inx 9813 7 T T NNP cord-010092-uftc8inx 9813 8 ) ) -RRB- cord-010092-uftc8inx 9813 9 is be VBZ cord-010092-uftc8inx 9813 10 predicted predict VBN cord-010092-uftc8inx 9813 11 to to TO cord-010092-uftc8inx 9813 12 be be VB cord-010092-uftc8inx 9813 13 B B NNP cord-010092-uftc8inx 9813 14 , , , cord-010092-uftc8inx 9813 15 as as IN cord-010092-uftc8inx 9813 16 evidenced evidence VBN cord-010092-uftc8inx 9813 17 by by IN cord-010092-uftc8inx 9813 18 forward forward RB cord-010092-uftc8inx 9813 19 typing type VBG cord-010092-uftc8inx 9813 20 on on IN cord-010092-uftc8inx 9813 21 Immucor Immucor NNP cord-010092-uftc8inx 9813 22 NEO NEO NNP cord-010092-uftc8inx 9813 23 and and CC cord-010092-uftc8inx 9813 24 reverse reverse VB cord-010092-uftc8inx 9813 25 manual manual JJ cord-010092-uftc8inx 9813 26 typing typing NN cord-010092-uftc8inx 9813 27 . . . cord-010092-uftc8inx 9814 1 Case case NN cord-010092-uftc8inx 9814 2 # # NN cord-010092-uftc8inx 9814 3 4 4 CD cord-010092-uftc8inx 9814 4 is be VBZ cord-010092-uftc8inx 9814 5 a a DT cord-010092-uftc8inx 9814 6 prenatal prenatal JJ cord-010092-uftc8inx 9814 7 black black JJ cord-010092-uftc8inx 9814 8 patient patient NN cord-010092-uftc8inx 9814 9 with with IN cord-010092-uftc8inx 9814 10 an an DT cord-010092-uftc8inx 9814 11 ABO ABO NNP cord-010092-uftc8inx 9814 12 typing typing NN cord-010092-uftc8inx 9814 13 discrepancy discrepancy NN cord-010092-uftc8inx 9814 14 : : : cord-010092-uftc8inx 9815 1 Forward forward JJ cord-010092-uftc8inx 9815 2 type type NN cord-010092-uftc8inx 9815 3 O o NN cord-010092-uftc8inx 9815 4 in in IN cord-010092-uftc8inx 9815 5 gel gel NN cord-010092-uftc8inx 9815 6 , , , cord-010092-uftc8inx 9815 7 A a DT cord-010092-uftc8inx 9815 8 2 2 CD cord-010092-uftc8inx 9815 9 + + SYM cord-010092-uftc8inx 9815 10 mixed mixed JJ cord-010092-uftc8inx 9815 11 field field NN cord-010092-uftc8inx 9815 12 ( ( -LRB- cord-010092-uftc8inx 9815 13 mf mf NNP cord-010092-uftc8inx 9815 14 ) ) -RRB- cord-010092-uftc8inx 9815 15 in in IN cord-010092-uftc8inx 9815 16 tube tube NN cord-010092-uftc8inx 9815 17 . . . cord-010092-uftc8inx 9816 1 Reverse reverse JJ cord-010092-uftc8inx 9816 2 type type NN cord-010092-uftc8inx 9816 3 on on IN cord-010092-uftc8inx 9816 4 A1 a1 NN cord-010092-uftc8inx 9816 5 cells cell NNS cord-010092-uftc8inx 9816 6 1 1 CD cord-010092-uftc8inx 9816 7 + + CD cord-010092-uftc8inx 9816 8 in in IN cord-010092-uftc8inx 9816 9 gel gel NN cord-010092-uftc8inx 9816 10 , , , cord-010092-uftc8inx 9817 1 0/1 0/1 LS cord-010092-uftc8inx 9817 2 + + CC cord-010092-uftc8inx 9817 3 in in IN cord-010092-uftc8inx 9817 4 tube tube NN cord-010092-uftc8inx 9817 5 . . . cord-010092-uftc8inx 9818 1 Sequencing sequencing NN cord-010092-uftc8inx 9818 2 of of IN cord-010092-uftc8inx 9818 3 genomic genomic JJ cord-010092-uftc8inx 9818 4 DNA dna NN cord-010092-uftc8inx 9818 5 and and CC cord-010092-uftc8inx 9818 6 cloned clone VBN cord-010092-uftc8inx 9818 7 PCR PCR NNP cord-010092-uftc8inx 9818 8 products product NNS cord-010092-uftc8inx 9818 9 covering cover VBG cord-010092-uftc8inx 9818 10 exons exon NNS cord-010092-uftc8inx 9818 11 6 6 CD cord-010092-uftc8inx 9818 12 - - SYM cord-010092-uftc8inx 9818 13 7 7 CD cord-010092-uftc8inx 9819 1 detected detect VBN cord-010092-uftc8inx 9819 2 variant variant NN cord-010092-uftc8inx 9820 1 c.784 c.784 NNP cord-010092-uftc8inx 9820 2 G G NNP cord-010092-uftc8inx 9821 1 > > XX cord-010092-uftc8inx 9822 1 C C NNP cord-010092-uftc8inx 9822 2 ( ( -LRB- cord-010092-uftc8inx 9822 3 Asp262His Asp262His NFP cord-010092-uftc8inx 9822 4 ) ) -RRB- cord-010092-uftc8inx 9822 5 in in IN cord-010092-uftc8inx 9822 6 heterozygosity heterozygosity NN cord-010092-uftc8inx 9822 7 , , , cord-010092-uftc8inx 9822 8 and and CC cord-010092-uftc8inx 9822 9 in in IN cord-010092-uftc8inx 9822 10 trans trans NNP cord-010092-uftc8inx 9822 11 an an DT cord-010092-uftc8inx 9822 12 ABO*O.01.09 ABO*O.01.09 NNP cord-010092-uftc8inx 9822 13 allele allele NN cord-010092-uftc8inx 9822 14 . . . cord-010092-uftc8inx 9823 1 Case case NN cord-010092-uftc8inx 9823 2 # # NN cord-010092-uftc8inx 9823 3 5 5 CD cord-010092-uftc8inx 9823 4 is be VBZ cord-010092-uftc8inx 9823 5 the the DT cord-010092-uftc8inx 9823 6 newborn newborn JJ cord-010092-uftc8inx 9823 7 baby baby NN cord-010092-uftc8inx 9823 8 of of IN cord-010092-uftc8inx 9823 9 case case NN cord-010092-uftc8inx 9823 10 # # $ cord-010092-uftc8inx 9823 11 4 4 CD cord-010092-uftc8inx 9823 12 , , , cord-010092-uftc8inx 9823 13 with with IN cord-010092-uftc8inx 9824 1 a a DT cord-010092-uftc8inx 9824 2 forward forward JJ cord-010092-uftc8inx 9824 3 type type NN cord-010092-uftc8inx 9824 4 A a NN cord-010092-uftc8inx 9825 1 1 1 LS cord-010092-uftc8inx 9825 2 + + SYM cord-010092-uftc8inx 9825 3 mf mf NN cord-010092-uftc8inx 9825 4 in in IN cord-010092-uftc8inx 9825 5 gel gel NN cord-010092-uftc8inx 9825 6 , , , cord-010092-uftc8inx 9825 7 A A NNP cord-010092-uftc8inx 9825 8 3 3 CD cord-010092-uftc8inx 9825 9 + + SYM cord-010092-uftc8inx 9825 10 mf mf NN cord-010092-uftc8inx 9825 11 in in IN cord-010092-uftc8inx 9825 12 tube tube NN cord-010092-uftc8inx 9825 13 . . . cord-010092-uftc8inx 9826 1 Sequencing sequencing NN cord-010092-uftc8inx 9826 2 of of IN cord-010092-uftc8inx 9826 3 the the DT cord-010092-uftc8inx 9826 4 baby baby NN cord-010092-uftc8inx 9826 5 's 's POS cord-010092-uftc8inx 9826 6 DNA dna NN cord-010092-uftc8inx 9826 7 detected detect VBN cord-010092-uftc8inx 9826 8 variant variant NN cord-010092-uftc8inx 9827 1 c.784 c.784 NNP cord-010092-uftc8inx 9827 2 G g NN cord-010092-uftc8inx 9827 3 > > XX cord-010092-uftc8inx 9828 1 C C NNP cord-010092-uftc8inx 9828 2 ( ( -LRB- cord-010092-uftc8inx 9828 3 Asp262His Asp262His NFP cord-010092-uftc8inx 9828 4 ) ) -RRB- cord-010092-uftc8inx 9828 5 in in IN cord-010092-uftc8inx 9828 6 heterozygosity heterozygosity NN cord-010092-uftc8inx 9828 7 , , , cord-010092-uftc8inx 9828 8 and and CC cord-010092-uftc8inx 9828 9 in in IN cord-010092-uftc8inx 9828 10 trans trans NNP cord-010092-uftc8inx 9828 11 an an DT cord-010092-uftc8inx 9828 12 ABO*B.01 abo*b.01 JJ cord-010092-uftc8inx 9828 13 allele allele NN cord-010092-uftc8inx 9828 14 . . . cord-010092-uftc8inx 9829 1 From from IN cord-010092-uftc8inx 9829 2 these these DT cord-010092-uftc8inx 9829 3 results result NNS cord-010092-uftc8inx 9829 4 it -PRON- PRP cord-010092-uftc8inx 9829 5 is be VBZ cord-010092-uftc8inx 9829 6 inferred infer VBN cord-010092-uftc8inx 9829 7 that that IN cord-010092-uftc8inx 9829 8 the the DT cord-010092-uftc8inx 9829 9 phenotype phenotype NN cord-010092-uftc8inx 9829 10 encoded encode VBN cord-010092-uftc8inx 9829 11 by by IN cord-010092-uftc8inx 9829 12 allele allele NN cord-010092-uftc8inx 9829 13 ABO*784C abo*784c NN cord-010092-uftc8inx 9829 14 is be VBZ cord-010092-uftc8inx 9829 15 A3-like a3-like ADD cord-010092-uftc8inx 9829 16 . . . cord-010092-uftc8inx 9830 1 Case case NN cord-010092-uftc8inx 9830 2 # # $ cord-010092-uftc8inx 9830 3 6 6 CD cord-010092-uftc8inx 9830 4 is be VBZ cord-010092-uftc8inx 9830 5 an an DT cord-010092-uftc8inx 9830 6 18 18 CD cord-010092-uftc8inx 9830 7 year year NN cord-010092-uftc8inx 9830 8 - - HYPH cord-010092-uftc8inx 9830 9 old old JJ cord-010092-uftc8inx 9830 10 hispanic hispanic JJ cord-010092-uftc8inx 9830 11 donor donor NN cord-010092-uftc8inx 9830 12 with with IN cord-010092-uftc8inx 9830 13 an an DT cord-010092-uftc8inx 9830 14 ABO ABO NNP cord-010092-uftc8inx 9830 15 typing typing NN cord-010092-uftc8inx 9830 16 discrepancy discrepancy NN cord-010092-uftc8inx 9830 17 : : : cord-010092-uftc8inx 9831 1 Forward forward JJ cord-010092-uftc8inx 9831 2 type type NN cord-010092-uftc8inx 9831 3 A a NN cord-010092-uftc8inx 9831 4 , , , cord-010092-uftc8inx 9831 5 reverse reverse JJ cord-010092-uftc8inx 9831 6 type type NN cord-010092-uftc8inx 9831 7 O. O. NNP cord-010092-uftc8inx 9831 8 Sequencing Sequencing NNP cord-010092-uftc8inx 9831 9 of of IN cord-010092-uftc8inx 9831 10 genomic genomic JJ cord-010092-uftc8inx 9831 11 DNA dna NN cord-010092-uftc8inx 9831 12 and and CC cord-010092-uftc8inx 9831 13 ABO ABO NNP cord-010092-uftc8inx 9831 14 exons exon NNS cord-010092-uftc8inx 9831 15 5 5 CD cord-010092-uftc8inx 9831 16 - - SYM cord-010092-uftc8inx 9831 17 6 6 CD cord-010092-uftc8inx 9831 18 and and CC cord-010092-uftc8inx 9831 19 6 6 CD cord-010092-uftc8inx 9831 20 - - SYM cord-010092-uftc8inx 9831 21 7 7 CD cord-010092-uftc8inx 9832 1 detected detect VBN cord-010092-uftc8inx 9832 2 variant variant NN cord-010092-uftc8inx 9833 1 c.979C c.979C NNP cord-010092-uftc8inx 9833 2 > > XX cord-010092-uftc8inx 9834 1 T T NNP cord-010092-uftc8inx 9834 2 ( ( -LRB- cord-010092-uftc8inx 9834 3 Gln327Ter Gln327Ter NNP cord-010092-uftc8inx 9834 4 ) ) -RRB- cord-010092-uftc8inx 9834 5 in in IN cord-010092-uftc8inx 9834 6 heterozygosity heterozygosity NN cord-010092-uftc8inx 9834 7 , , , cord-010092-uftc8inx 9834 8 and and CC cord-010092-uftc8inx 9834 9 in in IN cord-010092-uftc8inx 9834 10 trans trans NNP cord-010092-uftc8inx 9834 11 an an DT cord-010092-uftc8inx 9834 12 ABO*O.01.02 abo*o.01.02 JJ cord-010092-uftc8inx 9834 13 allele allele NN cord-010092-uftc8inx 9834 14 . . . cord-010092-uftc8inx 9835 1 The the DT cord-010092-uftc8inx 9835 2 truncation truncation NN cord-010092-uftc8inx 9835 3 of of IN cord-010092-uftc8inx 9835 4 the the DT cord-010092-uftc8inx 9835 5 A1 a1 NN cord-010092-uftc8inx 9835 6 transferase transferase NN cord-010092-uftc8inx 9835 7 at at IN cord-010092-uftc8inx 9835 8 such such PDT cord-010092-uftc8inx 9835 9 a a DT cord-010092-uftc8inx 9835 10 relatively relatively RB cord-010092-uftc8inx 9835 11 late late JJ cord-010092-uftc8inx 9835 12 position position NN cord-010092-uftc8inx 9835 13 is be VBZ cord-010092-uftc8inx 9835 14 consistent consistent JJ cord-010092-uftc8inx 9835 15 with with IN cord-010092-uftc8inx 9835 16 the the DT cord-010092-uftc8inx 9835 17 retention retention NN cord-010092-uftc8inx 9835 18 of of IN cord-010092-uftc8inx 9835 19 some some DT cord-010092-uftc8inx 9835 20 enzyme enzyme NN cord-010092-uftc8inx 9835 21 activity activity NN cord-010092-uftc8inx 9835 22 , , , cord-010092-uftc8inx 9835 23 explaining explain VBG cord-010092-uftc8inx 9835 24 the the DT cord-010092-uftc8inx 9835 25 forward forward NN cord-010092-uftc8inx 9835 26 A a DT cord-010092-uftc8inx 9835 27 type type NN cord-010092-uftc8inx 9835 28 encoded encode VBN cord-010092-uftc8inx 9835 29 by by IN cord-010092-uftc8inx 9835 30 allele allele NN cord-010092-uftc8inx 9835 31 ABO*979T. ABO*979T. NNP cord-010092-uftc8inx 9835 32 Summary Summary NNP cord-010092-uftc8inx 9835 33 / / SYM cord-010092-uftc8inx 9835 34 Conclusions conclusion NNS cord-010092-uftc8inx 9835 35 : : : cord-010092-uftc8inx 9836 1 Molecular molecular JJ cord-010092-uftc8inx 9836 2 characterization characterization NN cord-010092-uftc8inx 9836 3 of of IN cord-010092-uftc8inx 9836 4 ABO ABO NNP cord-010092-uftc8inx 9836 5 alleles allele NNS cord-010092-uftc8inx 9836 6 can can MD cord-010092-uftc8inx 9836 7 help help VB cord-010092-uftc8inx 9836 8 in in IN cord-010092-uftc8inx 9836 9 their -PRON- PRP$ cord-010092-uftc8inx 9836 10 future future JJ cord-010092-uftc8inx 9836 11 identification identification NN cord-010092-uftc8inx 9836 12 and and CC cord-010092-uftc8inx 9836 13 discrepancy discrepancy NN cord-010092-uftc8inx 9836 14 resolution resolution NN cord-010092-uftc8inx 9836 15 . . . cord-010092-uftc8inx 9837 1 Background background NN cord-010092-uftc8inx 9837 2 : : : cord-010092-uftc8inx 9838 1 Expression expression NN cord-010092-uftc8inx 9838 2 of of IN cord-010092-uftc8inx 9838 3 ABO ABO NNP cord-010092-uftc8inx 9838 4 transferase transferase NN cord-010092-uftc8inx 9838 5 genes gene NNS cord-010092-uftc8inx 9838 6 can can MD cord-010092-uftc8inx 9838 7 be be VB cord-010092-uftc8inx 9838 8 affected affect VBN cord-010092-uftc8inx 9838 9 by by IN cord-010092-uftc8inx 9838 10 genetic genetic JJ cord-010092-uftc8inx 9838 11 variants variant NNS cord-010092-uftc8inx 9838 12 located locate VBN cord-010092-uftc8inx 9838 13 within within IN cord-010092-uftc8inx 9838 14 the the DT cord-010092-uftc8inx 9838 15 coding coding NN cord-010092-uftc8inx 9838 16 sequence sequence NN cord-010092-uftc8inx 9838 17 , , , cord-010092-uftc8inx 9838 18 at at IN cord-010092-uftc8inx 9838 19 splice splice NN cord-010092-uftc8inx 9838 20 junctions junction NNS cord-010092-uftc8inx 9838 21 , , , cord-010092-uftc8inx 9838 22 in in IN cord-010092-uftc8inx 9838 23 the the DT cord-010092-uftc8inx 9838 24 proximal proximal JJ cord-010092-uftc8inx 9838 25 promoter promoter NN cord-010092-uftc8inx 9838 26 and and CC cord-010092-uftc8inx 9838 27 in in IN cord-010092-uftc8inx 9838 28 the the DT cord-010092-uftc8inx 9838 29 intron intron NN cord-010092-uftc8inx 9838 30 1 1 CD cord-010092-uftc8inx 9838 31 enhancer enhancer NN cord-010092-uftc8inx 9838 32 . . . cord-010092-uftc8inx 9839 1 Variants variant NNS cord-010092-uftc8inx 9839 2 reported report VBD cord-010092-uftc8inx 9839 3 to to IN cord-010092-uftc8inx 9839 4 date date NN cord-010092-uftc8inx 9839 5 in in IN cord-010092-uftc8inx 9839 6 the the DT cord-010092-uftc8inx 9839 7 intron intron NN cord-010092-uftc8inx 9839 8 1 1 CD cord-010092-uftc8inx 9839 9 enhancer enhancer NN cord-010092-uftc8inx 9839 10 include include VBP cord-010092-uftc8inx 9839 11 large large JJ cord-010092-uftc8inx 9839 12 deletions deletion NNS cord-010092-uftc8inx 9839 13 , , , cord-010092-uftc8inx 9839 14 small small JJ cord-010092-uftc8inx 9839 15 deletions deletion NNS cord-010092-uftc8inx 9839 16 and and CC cord-010092-uftc8inx 9839 17 single single JJ cord-010092-uftc8inx 9839 18 - - HYPH cord-010092-uftc8inx 9839 19 nucleotide nucleotide NN cord-010092-uftc8inx 9839 20 substitutions substitution NNS cord-010092-uftc8inx 9839 21 . . . cord-010092-uftc8inx 9840 1 Here here RB cord-010092-uftc8inx 9840 2 we -PRON- PRP cord-010092-uftc8inx 9840 3 describe describe VBP cord-010092-uftc8inx 9840 4 four four CD cord-010092-uftc8inx 9840 5 new new JJ cord-010092-uftc8inx 9840 6 alleles allele NNS cord-010092-uftc8inx 9840 7 with with IN cord-010092-uftc8inx 9840 8 single single JJ cord-010092-uftc8inx 9840 9 - - HYPH cord-010092-uftc8inx 9840 10 nucleotide nucleotide NN cord-010092-uftc8inx 9840 11 substitutions substitution NNS cord-010092-uftc8inx 9840 12 found find VBN cord-010092-uftc8inx 9840 13 in in IN cord-010092-uftc8inx 9840 14 samples sample NNS cord-010092-uftc8inx 9840 15 with with IN cord-010092-uftc8inx 9840 16 discrepant discrepant JJ cord-010092-uftc8inx 9840 17 or or CC cord-010092-uftc8inx 9840 18 unusual unusual JJ cord-010092-uftc8inx 9840 19 ABO ABO NNP cord-010092-uftc8inx 9840 20 serology serology NN cord-010092-uftc8inx 9840 21 . . . cord-010092-uftc8inx 9841 1 Aims aim VBZ cord-010092-uftc8inx 9841 2 : : : cord-010092-uftc8inx 9842 1 To to TO cord-010092-uftc8inx 9842 2 resolve resolve VB cord-010092-uftc8inx 9842 3 serological serological JJ cord-010092-uftc8inx 9842 4 discrepancies discrepancy NNS cord-010092-uftc8inx 9842 5 or or CC cord-010092-uftc8inx 9842 6 unusual unusual JJ cord-010092-uftc8inx 9842 7 serological serological JJ cord-010092-uftc8inx 9842 8 findings finding NNS cord-010092-uftc8inx 9842 9 in in IN cord-010092-uftc8inx 9842 10 the the DT cord-010092-uftc8inx 9842 11 ABO ABO NNP cord-010092-uftc8inx 9842 12 blood blood NN cord-010092-uftc8inx 9842 13 group group NN cord-010092-uftc8inx 9842 14 system system NN cord-010092-uftc8inx 9842 15 by by IN cord-010092-uftc8inx 9842 16 molecular molecular JJ cord-010092-uftc8inx 9842 17 methods method NNS cord-010092-uftc8inx 9842 18 , , , cord-010092-uftc8inx 9842 19 in in IN cord-010092-uftc8inx 9842 20 particular particular JJ cord-010092-uftc8inx 9842 21 by by IN cord-010092-uftc8inx 9842 22 Sanger Sanger NNP cord-010092-uftc8inx 9842 23 sequencing sequencing NN cord-010092-uftc8inx 9842 24 . . . cord-010092-uftc8inx 9843 1 Methods method NNS cord-010092-uftc8inx 9843 2 : : : cord-010092-uftc8inx 9844 1 Forward forward RB cord-010092-uftc8inx 9844 2 and and CC cord-010092-uftc8inx 9844 3 reverse reverse VB cord-010092-uftc8inx 9844 4 ABO ABO NNP cord-010092-uftc8inx 9844 5 phenotyping phenotyping NN cord-010092-uftc8inx 9844 6 was be VBD cord-010092-uftc8inx 9844 7 performed perform VBN cord-010092-uftc8inx 9844 8 by by IN cord-010092-uftc8inx 9844 9 the the DT cord-010092-uftc8inx 9844 10 gel gel NN cord-010092-uftc8inx 9844 11 or or CC cord-010092-uftc8inx 9844 12 tube tube NN cord-010092-uftc8inx 9844 13 methods method NNS cord-010092-uftc8inx 9844 14 . . . cord-010092-uftc8inx 9845 1 Adsorption adsorption NN cord-010092-uftc8inx 9845 2 - - HYPH cord-010092-uftc8inx 9845 3 elution elution NNP cord-010092-uftc8inx 9845 4 by by IN cord-010092-uftc8inx 9845 5 the the DT cord-010092-uftc8inx 9845 6 heat heat NN cord-010092-uftc8inx 9845 7 elution elution NN cord-010092-uftc8inx 9845 8 method method NN cord-010092-uftc8inx 9845 9 and and CC cord-010092-uftc8inx 9845 10 testing testing NN cord-010092-uftc8inx 9845 11 for for IN cord-010092-uftc8inx 9845 12 H h NN cord-010092-uftc8inx 9845 13 and and CC cord-010092-uftc8inx 9845 14 A a DT cord-010092-uftc8inx 9845 15 substances substance NNS cord-010092-uftc8inx 9845 16 in in IN cord-010092-uftc8inx 9845 17 saliva saliva NN cord-010092-uftc8inx 9845 18 were be VBD cord-010092-uftc8inx 9845 19 performed perform VBN cord-010092-uftc8inx 9845 20 by by IN cord-010092-uftc8inx 9845 21 following follow VBG cord-010092-uftc8inx 9845 22 the the DT cord-010092-uftc8inx 9845 23 procedures procedure NNS cord-010092-uftc8inx 9845 24 in in IN cord-010092-uftc8inx 9845 25 the the DT cord-010092-uftc8inx 9845 26 AABB AABB NNP cord-010092-uftc8inx 9845 27 technical technical JJ cord-010092-uftc8inx 9845 28 manual manual NN cord-010092-uftc8inx 9845 29 . . . cord-010092-uftc8inx 9846 1 Genomic genomic JJ cord-010092-uftc8inx 9846 2 DNA dna NN cord-010092-uftc8inx 9846 3 extracted extract VBN cord-010092-uftc8inx 9846 4 from from IN cord-010092-uftc8inx 9846 5 whole whole JJ cord-010092-uftc8inx 9846 6 blood blood NN cord-010092-uftc8inx 9846 7 was be VBD cord-010092-uftc8inx 9846 8 PCR PCR NNP cord-010092-uftc8inx 9846 9 amplified amplify VBN cord-010092-uftc8inx 9846 10 to to TO cord-010092-uftc8inx 9846 11 cover cover VB cord-010092-uftc8inx 9846 12 the the DT cord-010092-uftc8inx 9846 13 entire entire JJ cord-010092-uftc8inx 9846 14 ABO ABO NNP cord-010092-uftc8inx 9846 15 coding coding NN cord-010092-uftc8inx 9846 16 sequence sequence NN cord-010092-uftc8inx 9846 17 , , , cord-010092-uftc8inx 9846 18 splice splice NN cord-010092-uftc8inx 9846 19 junctions junction NNS cord-010092-uftc8inx 9846 20 , , , cord-010092-uftc8inx 9846 21 proximal proximal JJ cord-010092-uftc8inx 9846 22 promoter promoter NN cord-010092-uftc8inx 9846 23 and and CC cord-010092-uftc8inx 9846 24 intron intron NN cord-010092-uftc8inx 9846 25 1 1 CD cord-010092-uftc8inx 9846 26 enhancer enhancer NN cord-010092-uftc8inx 9846 27 . . . cord-010092-uftc8inx 9847 1 Amplification amplification NN cord-010092-uftc8inx 9847 2 products product NNS cord-010092-uftc8inx 9847 3 were be VBD cord-010092-uftc8inx 9847 4 Sanger Sanger NNP cord-010092-uftc8inx 9847 5 sequenced sequence VBN cord-010092-uftc8inx 9847 6 directly directly RB cord-010092-uftc8inx 9847 7 or or CC cord-010092-uftc8inx 9847 8 after after IN cord-010092-uftc8inx 9847 9 cloning clone VBG cord-010092-uftc8inx 9847 10 in in IN cord-010092-uftc8inx 9847 11 a a DT cord-010092-uftc8inx 9847 12 bacterial bacterial JJ cord-010092-uftc8inx 9847 13 plasmid plasmid NN cord-010092-uftc8inx 9847 14 vector vector NN cord-010092-uftc8inx 9847 15 . . . cord-010092-uftc8inx 9848 1 Background background NN cord-010092-uftc8inx 9848 2 : : : cord-010092-uftc8inx 9849 1 Inactive inactive JJ cord-010092-uftc8inx 9849 2 alleles allele NNS cord-010092-uftc8inx 9849 3 of of IN cord-010092-uftc8inx 9849 4 the the DT cord-010092-uftc8inx 9849 5 FUT1 FUT1 NNP cord-010092-uftc8inx 9849 6 could could MD cord-010092-uftc8inx 9849 7 be be VB cord-010092-uftc8inx 9849 8 decreased decrease VBN cord-010092-uftc8inx 9849 9 or or CC cord-010092-uftc8inx 9849 10 aborted abort VBN cord-010092-uftc8inx 9849 11 the the DT cord-010092-uftc8inx 9849 12 activity activity NN cord-010092-uftc8inx 9849 13 of of IN cord-010092-uftc8inx 9849 14 the the DT cord-010092-uftc8inx 9849 15 fucosyltransferase fucosyltransferase NN cord-010092-uftc8inx 9849 16 , , , cord-010092-uftc8inx 9849 17 which which WDT cord-010092-uftc8inx 9849 18 results result VBZ cord-010092-uftc8inx 9849 19 in in RP cord-010092-uftc8inx 9849 20 to to TO cord-010092-uftc8inx 9849 21 form form VB cord-010092-uftc8inx 9849 22 the the DT cord-010092-uftc8inx 9849 23 Bombay Bombay NNP cord-010092-uftc8inx 9849 24 or or CC cord-010092-uftc8inx 9849 25 para para NNP cord-010092-uftc8inx 9849 26 - - HYPH cord-010092-uftc8inx 9849 27 Bombay Bombay NNP cord-010092-uftc8inx 9849 28 phenotype phenotype NN cord-010092-uftc8inx 9849 29 with with IN cord-010092-uftc8inx 9849 30 weak weak JJ cord-010092-uftc8inx 9849 31 or or CC cord-010092-uftc8inx 9849 32 no no DT cord-010092-uftc8inx 9849 33 H h NN cord-010092-uftc8inx 9849 34 antigen antigen NN cord-010092-uftc8inx 9849 35 expression expression NN cord-010092-uftc8inx 9849 36 on on IN cord-010092-uftc8inx 9849 37 erythrocytes erythrocyte NNS cord-010092-uftc8inx 9849 38 . . . cord-010092-uftc8inx 9850 1 Now now RB cord-010092-uftc8inx 9850 2 many many JJ cord-010092-uftc8inx 9850 3 para para NNP cord-010092-uftc8inx 9850 4 - - HYPH cord-010092-uftc8inx 9850 5 Bombay Bombay NNP cord-010092-uftc8inx 9850 6 individuals individual NNS cord-010092-uftc8inx 9850 7 have have VBP cord-010092-uftc8inx 9850 8 been be VBN cord-010092-uftc8inx 9850 9 found find VBN cord-010092-uftc8inx 9850 10 in in IN cord-010092-uftc8inx 9850 11 the the DT cord-010092-uftc8inx 9850 12 Chinese chinese JJ cord-010092-uftc8inx 9850 13 population population NN cord-010092-uftc8inx 9850 14 . . . cord-010092-uftc8inx 9851 1 According accord VBG cord-010092-uftc8inx 9851 2 to to IN cord-010092-uftc8inx 9851 3 names name NNS cord-010092-uftc8inx 9851 4 for for IN cord-010092-uftc8inx 9851 5 H H NNP cord-010092-uftc8inx 9851 6 blood blood NN cord-010092-uftc8inx 9851 7 group group NN cord-010092-uftc8inx 9851 8 alleles allele NNS cord-010092-uftc8inx 9852 1 v5.1 v5.1 NNP cord-010092-uftc8inx 9852 2 170221 170221 CD cord-010092-uftc8inx 9852 3 of of IN cord-010092-uftc8inx 9852 4 Red Red NNP cord-010092-uftc8inx 9852 5 Cell Cell NNP cord-010092-uftc8inx 9852 6 Immunogenetics Immunogenetics NNP cord-010092-uftc8inx 9852 7 and and CC cord-010092-uftc8inx 9852 8 Blood Blood NNP cord-010092-uftc8inx 9852 9 Group Group NNP cord-010092-uftc8inx 9852 10 Terminology Terminology NNP cord-010092-uftc8inx 9852 11 working work VBG cord-010092-uftc8inx 9852 12 group group NN cord-010092-uftc8inx 9852 13 of of IN cord-010092-uftc8inx 9852 14 the the DT cord-010092-uftc8inx 9852 15 ISBT ISBT NNP cord-010092-uftc8inx 9852 16 , , , cord-010092-uftc8inx 9852 17 55 55 CD cord-010092-uftc8inx 9852 18 FUT1 FUT1 NNP cord-010092-uftc8inx 9852 19 alleles allele NNS cord-010092-uftc8inx 9852 20 were be VBD cord-010092-uftc8inx 9852 21 identified identify VBN cord-010092-uftc8inx 9852 22 for for IN cord-010092-uftc8inx 9852 23 Bombay Bombay NNP cord-010092-uftc8inx 9852 24 or or CC cord-010092-uftc8inx 9852 25 para para NNP cord-010092-uftc8inx 9852 26 - - HYPH cord-010092-uftc8inx 9852 27 Bombay Bombay NNP cord-010092-uftc8inx 9852 28 phenotype phenotype NN cord-010092-uftc8inx 9852 29 around around IN cord-010092-uftc8inx 9852 30 the the DT cord-010092-uftc8inx 9852 31 world world NN cord-010092-uftc8inx 9852 32 . . . cord-010092-uftc8inx 9853 1 Aims aim VBZ cord-010092-uftc8inx 9853 2 : : : cord-010092-uftc8inx 9854 1 The the DT cord-010092-uftc8inx 9854 2 study study NN cord-010092-uftc8inx 9854 3 was be VBD cord-010092-uftc8inx 9854 4 explored explore VBN cord-010092-uftc8inx 9854 5 the the DT cord-010092-uftc8inx 9854 6 distribution distribution NN cord-010092-uftc8inx 9854 7 of of IN cord-010092-uftc8inx 9854 8 FUT1 FUT1 NNP cord-010092-uftc8inx 9854 9 alleles allele NNS cord-010092-uftc8inx 9854 10 for for IN cord-010092-uftc8inx 9854 11 the the DT cord-010092-uftc8inx 9854 12 19 19 CD cord-010092-uftc8inx 9854 13 Chinese chinese JJ cord-010092-uftc8inx 9854 14 individuals individual NNS cord-010092-uftc8inx 9854 15 with with IN cord-010092-uftc8inx 9854 16 Para Para NNP cord-010092-uftc8inx 9854 17 - - HYPH cord-010092-uftc8inx 9854 18 Bombay Bombay NNP cord-010092-uftc8inx 9854 19 phenotype phenotype NN cord-010092-uftc8inx 9854 20 . . . cord-010092-uftc8inx 9855 1 Methods method NNS cord-010092-uftc8inx 9855 2 : : : cord-010092-uftc8inx 9856 1 The the DT cord-010092-uftc8inx 9856 2 samples sample NNS cord-010092-uftc8inx 9856 3 were be VBD cord-010092-uftc8inx 9856 4 come come VBN cord-010092-uftc8inx 9856 5 from from IN cord-010092-uftc8inx 9856 6 the the DT cord-010092-uftc8inx 9856 7 blood blood NN cord-010092-uftc8inx 9856 8 donors donor NNS cord-010092-uftc8inx 9856 9 or or CC cord-010092-uftc8inx 9856 10 the the DT cord-010092-uftc8inx 9856 11 patients patient NNS cord-010092-uftc8inx 9856 12 . . . cord-010092-uftc8inx 9857 1 The the DT cord-010092-uftc8inx 9857 2 A A NNP cord-010092-uftc8inx 9857 3 , , , cord-010092-uftc8inx 9857 4 B b NN cord-010092-uftc8inx 9857 5 , , , cord-010092-uftc8inx 9857 6 H h NN cord-010092-uftc8inx 9857 7 antigens antigen NNS cord-010092-uftc8inx 9857 8 were be VBD cord-010092-uftc8inx 9857 9 determined determine VBN cord-010092-uftc8inx 9857 10 using use VBG cord-010092-uftc8inx 9857 11 conventional conventional JJ cord-010092-uftc8inx 9857 12 serological serological JJ cord-010092-uftc8inx 9857 13 method method NN cord-010092-uftc8inx 9857 14 according accord VBG cord-010092-uftc8inx 9857 15 to to IN cord-010092-uftc8inx 9857 16 the the DT cord-010092-uftc8inx 9857 17 manufacture manufacture NN cord-010092-uftc8inx 9857 18 's 's POS cord-010092-uftc8inx 9857 19 instruction instruction NN cord-010092-uftc8inx 9857 20 . . . cord-010092-uftc8inx 9858 1 The the DT cord-010092-uftc8inx 9858 2 sequences sequence NNS cord-010092-uftc8inx 9858 3 of of IN cord-010092-uftc8inx 9858 4 the the DT cord-010092-uftc8inx 9858 5 full full JJ cord-010092-uftc8inx 9858 6 coding coding NN cord-010092-uftc8inx 9858 7 region region NN cord-010092-uftc8inx 9858 8 for for IN cord-010092-uftc8inx 9858 9 FUT1 FUT1 NNP cord-010092-uftc8inx 9858 10 was be VBD cord-010092-uftc8inx 9858 11 amplified amplify VBN cord-010092-uftc8inx 9858 12 , , , cord-010092-uftc8inx 9858 13 then then RB cord-010092-uftc8inx 9858 14 amplicon amplicon NN cord-010092-uftc8inx 9858 15 was be VBD cord-010092-uftc8inx 9858 16 purified purify VBN cord-010092-uftc8inx 9858 17 with with IN cord-010092-uftc8inx 9858 18 enzymes enzyme NNS cord-010092-uftc8inx 9858 19 digestion digestion NN cord-010092-uftc8inx 9858 20 and and CC cord-010092-uftc8inx 9858 21 used use VBN cord-010092-uftc8inx 9858 22 as as IN cord-010092-uftc8inx 9858 23 template template NN cord-010092-uftc8inx 9858 24 for for IN cord-010092-uftc8inx 9858 25 sequencing sequencing NN cord-010092-uftc8inx 9858 26 bidirectionally bidirectionally RB cord-010092-uftc8inx 9858 27 . . . cord-010092-uftc8inx 9859 1 All all DT cord-010092-uftc8inx 9859 2 nucleotide nucleotide JJ cord-010092-uftc8inx 9859 3 sequences sequence NNS cord-010092-uftc8inx 9859 4 obtained obtain VBN cord-010092-uftc8inx 9859 5 were be VBD cord-010092-uftc8inx 9859 6 analyzed analyze VBN cord-010092-uftc8inx 9859 7 and and CC cord-010092-uftc8inx 9859 8 compared compare VBN cord-010092-uftc8inx 9859 9 with with IN cord-010092-uftc8inx 9859 10 standard standard JJ cord-010092-uftc8inx 9859 11 FUT1 FUT1 NNP cord-010092-uftc8inx 9859 12 sequence sequence NN cord-010092-uftc8inx 9859 13 . . . cord-010092-uftc8inx 9860 1 Results result NNS cord-010092-uftc8inx 9860 2 : : : cord-010092-uftc8inx 9861 1 Nineteen nineteen CD cord-010092-uftc8inx 9861 2 Chinese chinese JJ cord-010092-uftc8inx 9861 3 individuals individual NNS cord-010092-uftc8inx 9861 4 with with IN cord-010092-uftc8inx 9861 5 Para Para NNP cord-010092-uftc8inx 9861 6 - - HYPH cord-010092-uftc8inx 9861 7 Bombay Bombay NNP cord-010092-uftc8inx 9861 8 phenotype phenotype NN cord-010092-uftc8inx 9861 9 were be VBD cord-010092-uftc8inx 9861 10 identified identify VBN cord-010092-uftc8inx 9861 11 . . . cord-010092-uftc8inx 9862 1 Ten ten CD cord-010092-uftc8inx 9862 2 of of IN cord-010092-uftc8inx 9862 3 them -PRON- PRP cord-010092-uftc8inx 9862 4 were be VBD cord-010092-uftc8inx 9862 5 the the DT cord-010092-uftc8inx 9862 6 donors donor NNS cord-010092-uftc8inx 9862 7 and and CC cord-010092-uftc8inx 9862 8 nine nine CD cord-010092-uftc8inx 9862 9 individuals individual NNS cord-010092-uftc8inx 9862 10 were be VBD cord-010092-uftc8inx 9862 11 come come VBN cord-010092-uftc8inx 9862 12 from from IN cord-010092-uftc8inx 9862 13 the the DT cord-010092-uftc8inx 9862 14 hospital hospital NN cord-010092-uftc8inx 9862 15 . . . cord-010092-uftc8inx 9863 1 The the DT cord-010092-uftc8inx 9863 2 RBCs rbc NNS cord-010092-uftc8inx 9863 3 had have VBD cord-010092-uftc8inx 9863 4 a a DT cord-010092-uftc8inx 9863 5 very very RB cord-010092-uftc8inx 9863 6 weak weak JJ cord-010092-uftc8inx 9863 7 agglutination agglutination NN cord-010092-uftc8inx 9863 8 reaction reaction NN cord-010092-uftc8inx 9863 9 with with IN cord-010092-uftc8inx 9863 10 anti anti JJ cord-010092-uftc8inx 9863 11 - - NNP cord-010092-uftc8inx 9863 12 H h NN cord-010092-uftc8inx 9863 13 in in IN cord-010092-uftc8inx 9863 14 the the DT cord-010092-uftc8inx 9863 15 most most JJS cord-010092-uftc8inx 9863 16 of of IN cord-010092-uftc8inx 9863 17 the the DT cord-010092-uftc8inx 9863 18 individuals individual NNS cord-010092-uftc8inx 9863 19 . . . cord-010092-uftc8inx 9864 1 FUT1 FUT1 NNP cord-010092-uftc8inx 9864 2 homozygous homozygous JJ cord-010092-uftc8inx 9864 3 mutations mutation NNS cord-010092-uftc8inx 9864 4 were be VBD cord-010092-uftc8inx 9864 5 found find VBN cord-010092-uftc8inx 9864 6 in in IN cord-010092-uftc8inx 9864 7 the the DT cord-010092-uftc8inx 9864 8 12 12 CD cord-010092-uftc8inx 9864 9 individuals individual NNS cord-010092-uftc8inx 9864 10 and and CC cord-010092-uftc8inx 9864 11 FUT1 FUT1 NNP cord-010092-uftc8inx 9864 12 heterozygous heterozygous JJ cord-010092-uftc8inx 9864 13 changes change NNS cord-010092-uftc8inx 9864 14 were be VBD cord-010092-uftc8inx 9864 15 existed exist VBN cord-010092-uftc8inx 9864 16 in in IN cord-010092-uftc8inx 9864 17 7 7 CD cord-010092-uftc8inx 9864 18 individuals individual NNS cord-010092-uftc8inx 9864 19 after after IN cord-010092-uftc8inx 9864 20 bidirectionally bidirectionally RB cord-010092-uftc8inx 9864 21 sequencing sequence VBG cord-010092-uftc8inx 9864 22 . . . cord-010092-uftc8inx 9865 1 .05 .05 CD cord-010092-uftc8inx 9865 2 % % NN cord-010092-uftc8inx 9865 3 , , , cord-010092-uftc8inx 9865 4 7.89 7.89 CD cord-010092-uftc8inx 9865 5 % % NN cord-010092-uftc8inx 9865 6 , , , cord-010092-uftc8inx 9865 7 5.26 5.26 CD cord-010092-uftc8inx 9865 8 % % NN cord-010092-uftc8inx 9865 9 , , , cord-010092-uftc8inx 9865 10 5.26 5.26 CD cord-010092-uftc8inx 9865 11 % % NN cord-010092-uftc8inx 9865 12 , , , cord-010092-uftc8inx 9865 13 5.26 5.26 CD cord-010092-uftc8inx 9865 14 % % NN cord-010092-uftc8inx 9865 15 , , , cord-010092-uftc8inx 9865 16 2.63 2.63 CD cord-010092-uftc8inx 9865 17 % % NN cord-010092-uftc8inx 9865 18 , , , cord-010092-uftc8inx 9865 19 2.63 2.63 CD cord-010092-uftc8inx 9865 20 % % NN cord-010092-uftc8inx 9865 21 , , , cord-010092-uftc8inx 9865 22 2.63 2.63 CD cord-010092-uftc8inx 9865 23 % % NN cord-010092-uftc8inx 9865 24 respectively respectively RB cord-010092-uftc8inx 9865 25 in in IN cord-010092-uftc8inx 9865 26 the the DT cord-010092-uftc8inx 9865 27 19 19 CD cord-010092-uftc8inx 9865 28 individuals individual NNS cord-010092-uftc8inx 9865 29 with with IN cord-010092-uftc8inx 9865 30 Para Para NNP cord-010092-uftc8inx 9865 31 - - HYPH cord-010092-uftc8inx 9865 32 Bombay Bombay NNP cord-010092-uftc8inx 9865 33 phenotype phenotype NN cord-010092-uftc8inx 9865 34 . . . cord-010092-uftc8inx 9866 1 According accord VBG cord-010092-uftc8inx 9866 2 to to IN cord-010092-uftc8inx 9866 3 our -PRON- PRP$ cord-010092-uftc8inx 9866 4 previously previously RB cord-010092-uftc8inx 9866 5 reports report NNS cord-010092-uftc8inx 9866 6 , , , cord-010092-uftc8inx 9866 7 the the DT cord-010092-uftc8inx 9866 8 fucosyltransferase fucosyltransferase NN cord-010092-uftc8inx 9866 9 activity activity NN cord-010092-uftc8inx 9866 10 of of IN cord-010092-uftc8inx 9866 11 FUT1 FUT1 NNP cord-010092-uftc8inx 9866 12 * * NFP cord-010092-uftc8inx 9866 13 01N.06(c.551_552delAG 01n.06(c.551_552delag CD cord-010092-uftc8inx 9866 14 ) ) -RRB- cord-010092-uftc8inx 9866 15 , , , cord-010092-uftc8inx 9866 16 FUT1 FUT1 NNP cord-010092-uftc8inx 9866 17 * * NFP cord-010092-uftc8inx 9866 18 01W.09 01w.09 CD cord-010092-uftc8inx 9867 1 ( ( -LRB- cord-010092-uftc8inx 9867 2 c.658C c.658C NNP cord-010092-uftc8inx 9868 1 > > XX cord-010092-uftc8inx 9868 2 T T NNP cord-010092-uftc8inx 9868 3 ) ) -RRB- cord-010092-uftc8inx 9868 4 and and CC cord-010092-uftc8inx 9868 5 FUT1 FUT1 NNP cord-010092-uftc8inx 9868 6 * * NFP cord-010092-uftc8inx 9868 7 01W.01 01w.01 CD cord-010092-uftc8inx 9868 8 ( ( -LRB- cord-010092-uftc8inx 9869 1 c.293C c.293C NNP cord-010092-uftc8inx 9870 1 > > XX cord-010092-uftc8inx 9871 1 T T NNP cord-010092-uftc8inx 9871 2 ) ) -RRB- cord-010092-uftc8inx 9871 3 were be VBD cord-010092-uftc8inx 9871 4 abolished abolish VBN cord-010092-uftc8inx 9871 5 in in IN cord-010092-uftc8inx 9871 6 vitro vitro FW cord-010092-uftc8inx 9871 7 assay assay NN cord-010092-uftc8inx 9871 8 , , , cord-010092-uftc8inx 9871 9 while while IN cord-010092-uftc8inx 9871 10 FUT1 FUT1 NNP cord-010092-uftc8inx 9871 11 mRNA mRNA NNP cord-010092-uftc8inx 9871 12 levels level NNS cord-010092-uftc8inx 9871 13 of of IN cord-010092-uftc8inx 9871 14 them -PRON- PRP cord-010092-uftc8inx 9871 15 had have VBD cord-010092-uftc8inx 9871 16 no no DT cord-010092-uftc8inx 9871 17 effect effect NN cord-010092-uftc8inx 9871 18 compared compare VBN cord-010092-uftc8inx 9871 19 with with IN cord-010092-uftc8inx 9871 20 wild wild JJ cord-010092-uftc8inx 9871 21 type type NN cord-010092-uftc8inx 9871 22 . . . cord-010092-uftc8inx 9872 1 Summary Summary NNP cord-010092-uftc8inx 9872 2 / / SYM cord-010092-uftc8inx 9872 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 9872 4 : : : cord-010092-uftc8inx 9873 1 The the DT cord-010092-uftc8inx 9873 2 FUT1 FUT1 NNP cord-010092-uftc8inx 9873 3 mutations mutation NNS cord-010092-uftc8inx 9873 4 in in IN cord-010092-uftc8inx 9873 5 the the DT cord-010092-uftc8inx 9873 6 Para Para NNP cord-010092-uftc8inx 9873 7 - - HYPH cord-010092-uftc8inx 9873 8 Bombay Bombay NNP cord-010092-uftc8inx 9873 9 individuals individual NNS cord-010092-uftc8inx 9873 10 were be VBD cord-010092-uftc8inx 9873 11 various various JJ cord-010092-uftc8inx 9873 12 . . . cord-010092-uftc8inx 9874 1 The the DT cord-010092-uftc8inx 9874 2 most most RBS cord-010092-uftc8inx 9874 3 common common JJ cord-010092-uftc8inx 9874 4 FUT1 FUT1 NNP cord-010092-uftc8inx 9874 5 allele allele NN cord-010092-uftc8inx 9874 6 in in IN cord-010092-uftc8inx 9874 7 the the DT cord-010092-uftc8inx 9874 8 Chinese chinese JJ cord-010092-uftc8inx 9874 9 individuals individual NNS cord-010092-uftc8inx 9874 10 with with IN cord-010092-uftc8inx 9874 11 Para Para NNP cord-010092-uftc8inx 9874 12 - - HYPH cord-010092-uftc8inx 9874 13 Bombay Bombay NNP cord-010092-uftc8inx 9874 14 phenotype phenotype NN cord-010092-uftc8inx 9874 15 was be VBD cord-010092-uftc8inx 9874 16 FUT1 FUT1 NNP cord-010092-uftc8inx 9874 17 * * NFP cord-010092-uftc8inx 9874 18 01N.06(c.551_552delAG 01n.06(c.551_552delag CD cord-010092-uftc8inx 9874 19 ) ) -RRB- cord-010092-uftc8inx 9874 20 . . . cord-010092-uftc8inx 9875 1 Background background NN cord-010092-uftc8inx 9875 2 : : : cord-010092-uftc8inx 9876 1 The the DT cord-010092-uftc8inx 9876 2 regulatory regulatory JJ cord-010092-uftc8inx 9876 3 mechanism mechanism NN cord-010092-uftc8inx 9876 4 of of IN cord-010092-uftc8inx 9876 5 the the DT cord-010092-uftc8inx 9876 6 ABO ABO NNP cord-010092-uftc8inx 9876 7 gene gene NN cord-010092-uftc8inx 9876 8 is be VBZ cord-010092-uftc8inx 9876 9 complicated complicate VBN cord-010092-uftc8inx 9876 10 and and CC cord-010092-uftc8inx 9876 11 has have VBZ cord-010092-uftc8inx 9876 12 been be VBN cord-010092-uftc8inx 9876 13 investigated investigate VBN cord-010092-uftc8inx 9876 14 extensively extensively RB cord-010092-uftc8inx 9876 15 . . . cord-010092-uftc8inx 9877 1 Variation variation NN cord-010092-uftc8inx 9877 2 in in IN cord-010092-uftc8inx 9877 3 A a DT cord-010092-uftc8inx 9877 4 antigen antigen NN cord-010092-uftc8inx 9877 5 expression expression NN cord-010092-uftc8inx 9877 6 was be VBD cord-010092-uftc8inx 9877 7 recognized recognize VBN cord-010092-uftc8inx 9877 8 very very RB cord-010092-uftc8inx 9877 9 early early RB cord-010092-uftc8inx 9877 10 in in IN cord-010092-uftc8inx 9877 11 the the DT cord-010092-uftc8inx 9877 12 twentieth twentieth JJ cord-010092-uftc8inx 9877 13 century century NN cord-010092-uftc8inx 9877 14 and and CC cord-010092-uftc8inx 9877 15 the the DT cord-010092-uftc8inx 9877 16 A A NNP cord-010092-uftc8inx 9877 17 blood blood NN cord-010092-uftc8inx 9877 18 group group NN cord-010092-uftc8inx 9877 19 was be VBD cord-010092-uftc8inx 9877 20 divided divide VBN cord-010092-uftc8inx 9877 21 into into IN cord-010092-uftc8inx 9877 22 A1 A1 NNP cord-010092-uftc8inx 9877 23 and and CC cord-010092-uftc8inx 9877 24 A2 A2 NNP cord-010092-uftc8inx 9877 25 . . . cord-010092-uftc8inx 9878 1 Later later RB cord-010092-uftc8inx 9878 2 the the DT cord-010092-uftc8inx 9878 3 A a DT cord-010092-uftc8inx 9878 4 blood blood NN cord-010092-uftc8inx 9878 5 group group NN cord-010092-uftc8inx 9878 6 was be VBD cord-010092-uftc8inx 9878 7 subdivided subdivide VBN cord-010092-uftc8inx 9878 8 further further RB cord-010092-uftc8inx 9878 9 based base VBN cord-010092-uftc8inx 9878 10 on on IN cord-010092-uftc8inx 9878 11 characteristic characteristic JJ cord-010092-uftc8inx 9878 12 reactivity reactivity NN cord-010092-uftc8inx 9878 13 with with IN cord-010092-uftc8inx 9878 14 human human JJ cord-010092-uftc8inx 9878 15 polyclonal polyclonal JJ cord-010092-uftc8inx 9878 16 antisera antisera NN cord-010092-uftc8inx 9878 17 , , , cord-010092-uftc8inx 9878 18 i.e. i.e. FW cord-010092-uftc8inx 9878 19 , , , cord-010092-uftc8inx 9878 20 strength strength NN cord-010092-uftc8inx 9878 21 of of IN cord-010092-uftc8inx 9878 22 reactivity reactivity NN cord-010092-uftc8inx 9878 23 and and CC cord-010092-uftc8inx 9878 24 presence presence NN cord-010092-uftc8inx 9878 25 of of IN cord-010092-uftc8inx 9878 26 mixed mixed JJ cord-010092-uftc8inx 9878 27 field field NN cord-010092-uftc8inx 9878 28 agglutination agglutination NN cord-010092-uftc8inx 9878 29 ; ; : cord-010092-uftc8inx 9878 30 presence presence NN cord-010092-uftc8inx 9878 31 of of IN cord-010092-uftc8inx 9878 32 anti anti NNP cord-010092-uftc8inx 9878 33 - - NNP cord-010092-uftc8inx 9878 34 A1 A1 NNP cord-010092-uftc8inx 9878 35 , , , cord-010092-uftc8inx 9878 36 and and CC cord-010092-uftc8inx 9878 37 whether whether IN cord-010092-uftc8inx 9878 38 A a NN cord-010092-uftc8inx 9878 39 or or CC cord-010092-uftc8inx 9878 40 H h NN cord-010092-uftc8inx 9878 41 blood blood NN cord-010092-uftc8inx 9878 42 group group NN cord-010092-uftc8inx 9878 43 substance substance NN cord-010092-uftc8inx 9878 44 was be VBD cord-010092-uftc8inx 9878 45 present present JJ cord-010092-uftc8inx 9878 46 in in IN cord-010092-uftc8inx 9878 47 the the DT cord-010092-uftc8inx 9878 48 saliva saliva NN cord-010092-uftc8inx 9878 49 of of IN cord-010092-uftc8inx 9878 50 secretor secretor NN cord-010092-uftc8inx 9878 51 subjects subject NNS cord-010092-uftc8inx 9878 52 . . . cord-010092-uftc8inx 9879 1 Mutations mutation NNS cord-010092-uftc8inx 9879 2 critical critical JJ cord-010092-uftc8inx 9879 3 for for IN cord-010092-uftc8inx 9879 4 ABO ABO NNP cord-010092-uftc8inx 9879 5 blood blood NN cord-010092-uftc8inx 9879 6 group group NN cord-010092-uftc8inx 9879 7 phenotypes phenotype NNS cord-010092-uftc8inx 9879 8 have have VBP cord-010092-uftc8inx 9879 9 predominantly predominantly RB cord-010092-uftc8inx 9879 10 been be VBN cord-010092-uftc8inx 9879 11 found find VBN cord-010092-uftc8inx 9879 12 in in IN cord-010092-uftc8inx 9879 13 exons exon NNS cord-010092-uftc8inx 9879 14 6 6 CD cord-010092-uftc8inx 9879 15 and and CC cord-010092-uftc8inx 9879 16 7 7 CD cord-010092-uftc8inx 9879 17 of of IN cord-010092-uftc8inx 9879 18 the the DT cord-010092-uftc8inx 9879 19 ABO ABO NNP cord-010092-uftc8inx 9879 20 gene gene NN cord-010092-uftc8inx 9879 21 , , , cord-010092-uftc8inx 9879 22 both both DT cord-010092-uftc8inx 9879 23 of of IN cord-010092-uftc8inx 9879 24 which which WDT cord-010092-uftc8inx 9879 25 encode encode VBP cord-010092-uftc8inx 9879 26 the the DT cord-010092-uftc8inx 9879 27 catalytic catalytic JJ cord-010092-uftc8inx 9879 28 domain domain NN cord-010092-uftc8inx 9879 29 of of IN cord-010092-uftc8inx 9879 30 ABO ABO NNP cord-010092-uftc8inx 9879 31 glycosyltransferase glycosyltransferase NNP cord-010092-uftc8inx 9879 32 . . . cord-010092-uftc8inx 9880 1 In in IN cord-010092-uftc8inx 9880 2 our -PRON- PRP$ cord-010092-uftc8inx 9880 3 case case NN cord-010092-uftc8inx 9880 4 report report NN cord-010092-uftc8inx 9880 5 we -PRON- PRP cord-010092-uftc8inx 9880 6 show show VBP cord-010092-uftc8inx 9880 7 how how WRB cord-010092-uftc8inx 9880 8 mutation mutation NN cord-010092-uftc8inx 9880 9 ranging range VBG cord-010092-uftc8inx 9880 10 from from IN cord-010092-uftc8inx 9880 11 single single JJ cord-010092-uftc8inx 9880 12 nucleotide nucleotide NN cord-010092-uftc8inx 9880 13 in in IN cord-010092-uftc8inx 9880 14 the the DT cord-010092-uftc8inx 9880 15 intron intron NN cord-010092-uftc8inx 9880 16 1 1 CD cord-010092-uftc8inx 9880 17 enhancer enhancer NN cord-010092-uftc8inx 9880 18 element element NN cord-010092-uftc8inx 9880 19 can can MD cord-010092-uftc8inx 9880 20 alter alter VB cord-010092-uftc8inx 9880 21 the the DT cord-010092-uftc8inx 9880 22 efficacy efficacy NN cord-010092-uftc8inx 9880 23 of of IN cord-010092-uftc8inx 9880 24 enzyme enzyme NN cord-010092-uftc8inx 9880 25 and and CC cord-010092-uftc8inx 9880 26 alter alter VB cord-010092-uftc8inx 9880 27 antigen antigen NN cord-010092-uftc8inx 9880 28 expression expression NN cord-010092-uftc8inx 9880 29 . . . cord-010092-uftc8inx 9881 1 Aims aim VBZ cord-010092-uftc8inx 9881 2 : : : cord-010092-uftc8inx 9882 1 This this DT cord-010092-uftc8inx 9882 2 study study NN cord-010092-uftc8inx 9882 3 aims aim VBZ cord-010092-uftc8inx 9882 4 to to TO cord-010092-uftc8inx 9882 5 investigate investigate VB cord-010092-uftc8inx 9882 6 the the DT cord-010092-uftc8inx 9882 7 molecular molecular JJ cord-010092-uftc8inx 9882 8 basis basis NN cord-010092-uftc8inx 9882 9 of of IN cord-010092-uftc8inx 9882 10 discrepant discrepant JJ cord-010092-uftc8inx 9882 11 results result NNS cord-010092-uftc8inx 9882 12 of of IN cord-010092-uftc8inx 9882 13 ABO ABO NNP cord-010092-uftc8inx 9882 14 forward forward RB cord-010092-uftc8inx 9882 15 / / SYM cord-010092-uftc8inx 9882 16 reverse reverse VBP cord-010092-uftc8inx 9882 17 typing typing NN cord-010092-uftc8inx 9882 18 in in IN cord-010092-uftc8inx 9882 19 blood blood NN cord-010092-uftc8inx 9882 20 donor donor NN cord-010092-uftc8inx 9882 21 . . . cord-010092-uftc8inx 9883 1 Methods method NNS cord-010092-uftc8inx 9883 2 : : : cord-010092-uftc8inx 9883 3 The the DT cord-010092-uftc8inx 9883 4 ABO ABO NNP cord-010092-uftc8inx 9883 5 typing typing NN cord-010092-uftc8inx 9883 6 was be VBD cord-010092-uftc8inx 9883 7 performed perform VBN cord-010092-uftc8inx 9883 8 using use VBG cord-010092-uftc8inx 9883 9 tube tube NN cord-010092-uftc8inx 9883 10 technique technique NN cord-010092-uftc8inx 9883 11 and and CC cord-010092-uftc8inx 9883 12 column column NN cord-010092-uftc8inx 9883 13 agglutination agglutination NN cord-010092-uftc8inx 9883 14 tests test NNS cord-010092-uftc8inx 9883 15 ( ( -LRB- cord-010092-uftc8inx 9883 16 Bio Bio NNP cord-010092-uftc8inx 9883 17 - - HYPH cord-010092-uftc8inx 9883 18 Rad Rad NNP cord-010092-uftc8inx 9883 19 , , , cord-010092-uftc8inx 9883 20 Grifols Grifols NNP cord-010092-uftc8inx 9883 21 ) ) -RRB- cord-010092-uftc8inx 9883 22 . . . cord-010092-uftc8inx 9884 1 Standard standard JJ cord-010092-uftc8inx 9884 2 tests test NNS cord-010092-uftc8inx 9884 3 were be VBD cord-010092-uftc8inx 9884 4 completed complete VBN cord-010092-uftc8inx 9884 5 with with IN cord-010092-uftc8inx 9884 6 adsorption adsorption NN cord-010092-uftc8inx 9884 7 - - HYPH cord-010092-uftc8inx 9884 8 elution elution NN cord-010092-uftc8inx 9884 9 study study NN cord-010092-uftc8inx 9884 10 using use VBG cord-010092-uftc8inx 9884 11 O o NN cord-010092-uftc8inx 9884 12 plasma plasma NN cord-010092-uftc8inx 9884 13 as as IN cord-010092-uftc8inx 9884 14 a a DT cord-010092-uftc8inx 9884 15 source source NN cord-010092-uftc8inx 9884 16 of of IN cord-010092-uftc8inx 9884 17 anti anti JJ cord-010092-uftc8inx 9884 18 - - JJ cord-010092-uftc8inx 9884 19 A a NN cord-010092-uftc8inx 9884 20 , , , cord-010092-uftc8inx 9884 21 and and CC cord-010092-uftc8inx 9884 22 with with IN cord-010092-uftc8inx 9884 23 saliva saliva NN cord-010092-uftc8inx 9884 24 testing testing NN cord-010092-uftc8inx 9884 25 for for IN cord-010092-uftc8inx 9884 26 presence presence NN cord-010092-uftc8inx 9884 27 of of IN cord-010092-uftc8inx 9884 28 A a NN cord-010092-uftc8inx 9884 29 and and CC cord-010092-uftc8inx 9884 30 H h NN cord-010092-uftc8inx 9884 31 substances substance NNS cord-010092-uftc8inx 9884 32 . . . cord-010092-uftc8inx 9885 1 We -PRON- PRP cord-010092-uftc8inx 9885 2 performed perform VBD cord-010092-uftc8inx 9885 3 quality quality NN cord-010092-uftc8inx 9885 4 control control NN cord-010092-uftc8inx 9885 5 for for IN cord-010092-uftc8inx 9885 6 these these DT cord-010092-uftc8inx 9885 7 methods method NNS cord-010092-uftc8inx 9885 8 . . . cord-010092-uftc8inx 9886 1 ABO ABO NNP cord-010092-uftc8inx 9886 2 group group NN cord-010092-uftc8inx 9886 3 genotyping genotyping NN cord-010092-uftc8inx 9886 4 was be VBD cord-010092-uftc8inx 9886 5 performed perform VBN cord-010092-uftc8inx 9886 6 using use VBG cord-010092-uftc8inx 9886 7 PCR PCR NNP cord-010092-uftc8inx 9886 8 with with IN cord-010092-uftc8inx 9886 9 sequence sequence NN cord-010092-uftc8inx 9886 10 - - HYPH cord-010092-uftc8inx 9886 11 specific specific JJ cord-010092-uftc8inx 9886 12 primer primer NN cord-010092-uftc8inx 9886 13 by by IN cord-010092-uftc8inx 9886 14 commercial commercial JJ cord-010092-uftc8inx 9886 15 kit kit NN cord-010092-uftc8inx 9886 16 ( ( -LRB- cord-010092-uftc8inx 9886 17 ABO ABO NNP cord-010092-uftc8inx 9886 18 - - HYPH cord-010092-uftc8inx 9886 19 variant variant NN cord-010092-uftc8inx 9886 20 ; ; : cord-010092-uftc8inx 9886 21 BAG BAG NNP cord-010092-uftc8inx 9886 22 Healthcare Healthcare NNP cord-010092-uftc8inx 9886 23 , , , cord-010092-uftc8inx 9886 24 Lich Lich NNP cord-010092-uftc8inx 9886 25 , , , cord-010092-uftc8inx 9886 26 Germany Germany NNP cord-010092-uftc8inx 9886 27 ) ) -RRB- cord-010092-uftc8inx 9886 28 . . . cord-010092-uftc8inx 9887 1 PCR PCR NNP cord-010092-uftc8inx 9887 2 - - HYPH cord-010092-uftc8inx 9887 3 amplified amplify VBN cord-010092-uftc8inx 9887 4 exons exon NNS cord-010092-uftc8inx 9887 5 and and CC cord-010092-uftc8inx 9887 6 intron intron NN cord-010092-uftc8inx 9887 7 1 1 CD cord-010092-uftc8inx 9887 8 enhancer enhancer NN cord-010092-uftc8inx 9887 9 were be VBD cord-010092-uftc8inx 9887 10 subject subject JJ cord-010092-uftc8inx 9887 11 to to IN cord-010092-uftc8inx 9887 12 bi bi JJ cord-010092-uftc8inx 9887 13 - - JJ cord-010092-uftc8inx 9887 14 directional directional JJ cord-010092-uftc8inx 9887 15 DNA dna NN cord-010092-uftc8inx 9887 16 sequence sequence NN cord-010092-uftc8inx 9887 17 analysis analysis NN cord-010092-uftc8inx 9887 18 using use VBG cord-010092-uftc8inx 9887 19 standard standard JJ cord-010092-uftc8inx 9887 20 Sanger Sanger NNP cord-010092-uftc8inx 9887 21 dideoxy dideoxy NN cord-010092-uftc8inx 9887 22 chemistry chemistry NN cord-010092-uftc8inx 9887 23 . . . cord-010092-uftc8inx 9888 1 Seqscape Seqscape NNP cord-010092-uftc8inx 9888 2 software software NN cord-010092-uftc8inx 9888 3 ( ( -LRB- cord-010092-uftc8inx 9888 4 ABI ABI NNP cord-010092-uftc8inx 9888 5 ) ) -RRB- cord-010092-uftc8inx 9888 6 was be VBD cord-010092-uftc8inx 9888 7 used use VBN cord-010092-uftc8inx 9888 8 to to TO cord-010092-uftc8inx 9888 9 analyze analyze VB cord-010092-uftc8inx 9888 10 sequence sequence NN cord-010092-uftc8inx 9888 11 data datum NNS cord-010092-uftc8inx 9888 12 by by IN cord-010092-uftc8inx 9888 13 comparing compare VBG cord-010092-uftc8inx 9888 14 the the DT cord-010092-uftc8inx 9888 15 obtained obtain VBN cord-010092-uftc8inx 9888 16 sequence sequence NN cord-010092-uftc8inx 9888 17 to to IN cord-010092-uftc8inx 9888 18 a a DT cord-010092-uftc8inx 9888 19 reference reference NN cord-010092-uftc8inx 9888 20 sequence sequence NN cord-010092-uftc8inx 9888 21 from from IN cord-010092-uftc8inx 9888 22 NCBI NCBI NNP cord-010092-uftc8inx 9888 23 . . . cord-010092-uftc8inx 9889 1 Results result NNS cord-010092-uftc8inx 9889 2 : : : cord-010092-uftc8inx 9890 1 Standard standard JJ cord-010092-uftc8inx 9890 2 serological serological JJ cord-010092-uftc8inx 9890 3 forward forward NN cord-010092-uftc8inx 9890 4 tests test NNS cord-010092-uftc8inx 9890 5 identified identify VBD cord-010092-uftc8inx 9890 6 blood blood NN cord-010092-uftc8inx 9890 7 group group NN cord-010092-uftc8inx 9890 8 O o NN cord-010092-uftc8inx 9890 9 , , , cord-010092-uftc8inx 9890 10 however however RB cord-010092-uftc8inx 9890 11 , , , cord-010092-uftc8inx 9890 12 only only RB cord-010092-uftc8inx 9890 13 anti anti JJ cord-010092-uftc8inx 9890 14 - - JJ cord-010092-uftc8inx 9890 15 B b JJ cord-010092-uftc8inx 9890 16 iso iso NN cord-010092-uftc8inx 9890 17 - - HYPH cord-010092-uftc8inx 9890 18 agglutinins agglutinin NNS cord-010092-uftc8inx 9890 19 were be VBD cord-010092-uftc8inx 9890 20 present present JJ cord-010092-uftc8inx 9890 21 . . . cord-010092-uftc8inx 9891 1 Anti Anti NNP cord-010092-uftc8inx 9891 2 - - NNP cord-010092-uftc8inx 9891 3 A a NN cord-010092-uftc8inx 9891 4 in in IN cord-010092-uftc8inx 9891 5 adsorption adsorption NN cord-010092-uftc8inx 9891 6 - - HYPH cord-010092-uftc8inx 9891 7 elution elution NN cord-010092-uftc8inx 9891 8 study study NN cord-010092-uftc8inx 9891 9 was be VBD cord-010092-uftc8inx 9891 10 successfully successfully RB cord-010092-uftc8inx 9891 11 adsorbed adsorb VBN cord-010092-uftc8inx 9891 12 and and CC cord-010092-uftc8inx 9891 13 eluted elute VBN cord-010092-uftc8inx 9891 14 from from IN cord-010092-uftc8inx 9891 15 the the DT cord-010092-uftc8inx 9891 16 investigated investigate VBN cord-010092-uftc8inx 9891 17 cells cell NNS cord-010092-uftc8inx 9891 18 . . . cord-010092-uftc8inx 9892 1 A a NN cord-010092-uftc8inx 9892 2 and and CC cord-010092-uftc8inx 9892 3 H h NN cord-010092-uftc8inx 9892 4 substances substance NNS cord-010092-uftc8inx 9892 5 were be VBD cord-010092-uftc8inx 9892 6 detected detect VBN cord-010092-uftc8inx 9892 7 in in IN cord-010092-uftc8inx 9892 8 saliva saliva NN cord-010092-uftc8inx 9892 9 . . . cord-010092-uftc8inx 9893 1 ABO ABO NNP cord-010092-uftc8inx 9893 2 genotyping genotyping NN cord-010092-uftc8inx 9893 3 using use VBG cord-010092-uftc8inx 9893 4 PCR PCR NNP cord-010092-uftc8inx 9893 5 - - HYPH cord-010092-uftc8inx 9893 6 SSP SSP NNP cord-010092-uftc8inx 9893 7 indicated indicate VBD cord-010092-uftc8inx 9893 8 genotype genotype NN cord-010092-uftc8inx 9893 9 O1v/ o1v/ RB cord-010092-uftc8inx 9894 1 A a DT cord-010092-uftc8inx 9894 2 1 1 CD cord-010092-uftc8inx 9894 3 . . . cord-010092-uftc8inx 9895 1 DNA dna NN cord-010092-uftc8inx 9895 2 sequence sequence NN cord-010092-uftc8inx 9895 3 analysis analysis NN cord-010092-uftc8inx 9895 4 showed show VBD cord-010092-uftc8inx 9895 5 result result NN cord-010092-uftc8inx 9895 6 ABO*A01 abo*a01 RB cord-010092-uftc8inx 9895 7 ( ( -LRB- cord-010092-uftc8inx 9895 8 28 28 CD cord-010092-uftc8inx 9895 9 + + SYM cord-010092-uftc8inx 9895 10 5859A 5859a CD cord-010092-uftc8inx 9895 11 ) ) -RRB- cord-010092-uftc8inx 9895 12 , , . cord-010092-uftc8inx 9896 1 ABO*O.01.02 ABO*O.01.02 NNP cord-010092-uftc8inx 9896 2 . . . cord-010092-uftc8inx 9897 1 The the DT cord-010092-uftc8inx 9897 2 specimen specimen NN cord-010092-uftc8inx 9897 3 was be VBD cord-010092-uftc8inx 9897 4 revealed reveal VBN cord-010092-uftc8inx 9897 5 as as IN cord-010092-uftc8inx 9897 6 an an DT cord-010092-uftc8inx 9897 7 A A NNP cord-010092-uftc8inx 9897 8 subgroup subgroup NN cord-010092-uftc8inx 9897 9 , , , cord-010092-uftc8inx 9897 10 probably probably RB cord-010092-uftc8inx 9897 11 A a DT cord-010092-uftc8inx 9897 12 m m NN cord-010092-uftc8inx 9897 13 with with IN cord-010092-uftc8inx 9897 14 an an DT cord-010092-uftc8inx 9897 15 unusual unusual JJ cord-010092-uftc8inx 9897 16 genetic genetic JJ cord-010092-uftc8inx 9897 17 variant variant NN cord-010092-uftc8inx 9897 18 in in IN cord-010092-uftc8inx 9897 19 the the DT cord-010092-uftc8inx 9897 20 intron intron NN cord-010092-uftc8inx 9897 21 region region NN cord-010092-uftc8inx 9897 22 of of IN cord-010092-uftc8inx 9897 23 the the DT cord-010092-uftc8inx 9897 24 ABO ABO NNP cord-010092-uftc8inx 9897 25 gene gene NN cord-010092-uftc8inx 9897 26 , , , cord-010092-uftc8inx 9897 27 the the DT cord-010092-uftc8inx 9897 28 enhancer enhancer NN cord-010092-uftc8inx 9897 29 of of IN cord-010092-uftc8inx 9897 30 the the DT cord-010092-uftc8inx 9897 31 gene gene NN cord-010092-uftc8inx 9897 32 expression expression NN cord-010092-uftc8inx 9897 33 . . . cord-010092-uftc8inx 9898 1 Summary Summary NNP cord-010092-uftc8inx 9898 2 / / SYM cord-010092-uftc8inx 9898 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 9898 4 : : : cord-010092-uftc8inx 9899 1 We -PRON- PRP cord-010092-uftc8inx 9899 2 report report VBP cord-010092-uftc8inx 9899 3 the the DT cord-010092-uftc8inx 9899 4 first first JJ cord-010092-uftc8inx 9899 5 case case NN cord-010092-uftc8inx 9899 6 of of IN cord-010092-uftc8inx 9899 7 ABO*A01(28 ABO*A01(28 NNP cord-010092-uftc8inx 9900 1 +5859A +5859A NNP cord-010092-uftc8inx 9900 2 ) ) -RRB- cord-010092-uftc8inx 9900 3 , , , cord-010092-uftc8inx 9900 4 the the DT cord-010092-uftc8inx 9900 5 mutation mutation NN cord-010092-uftc8inx 9900 6 located locate VBN cord-010092-uftc8inx 9900 7 in in IN cord-010092-uftc8inx 9900 8 the the DT cord-010092-uftc8inx 9900 9 enhancer enhancer NN cord-010092-uftc8inx 9900 10 region region NN cord-010092-uftc8inx 9900 11 of of IN cord-010092-uftc8inx 9900 12 gene gene NN cord-010092-uftc8inx 9900 13 expression expression NN cord-010092-uftc8inx 9900 14 in in IN cord-010092-uftc8inx 9900 15 allele allele NN cord-010092-uftc8inx 9900 16 A A NNP cord-010092-uftc8inx 9900 17 , , , cord-010092-uftc8inx 9900 18 that that WDT cord-010092-uftc8inx 9900 19 causes cause VBZ cord-010092-uftc8inx 9900 20 discrepant discrepant JJ cord-010092-uftc8inx 9900 21 results result NNS cord-010092-uftc8inx 9900 22 not not RB cord-010092-uftc8inx 9900 23 only only RB cord-010092-uftc8inx 9900 24 in in IN cord-010092-uftc8inx 9900 25 ABO ABO NNP cord-010092-uftc8inx 9900 26 forward forward RB cord-010092-uftc8inx 9900 27 / / SYM cord-010092-uftc8inx 9900 28 reverse reverse VBP cord-010092-uftc8inx 9900 29 typing typing NN cord-010092-uftc8inx 9900 30 but but CC cord-010092-uftc8inx 9900 31 also also RB cord-010092-uftc8inx 9900 32 in in IN cord-010092-uftc8inx 9900 33 molecular molecular JJ cord-010092-uftc8inx 9900 34 blood blood NN cord-010092-uftc8inx 9900 35 grouping grouping NN cord-010092-uftc8inx 9900 36 tests test NNS cord-010092-uftc8inx 9900 37 . . . cord-010092-uftc8inx 9901 1 Based base VBN cord-010092-uftc8inx 9901 2 on on IN cord-010092-uftc8inx 9901 3 our -PRON- PRP$ cord-010092-uftc8inx 9901 4 serological serological JJ cord-010092-uftc8inx 9901 5 findings finding NNS cord-010092-uftc8inx 9901 6 , , , cord-010092-uftc8inx 9901 7 this this DT cord-010092-uftc8inx 9901 8 subgroup subgroup NN cord-010092-uftc8inx 9901 9 is be VBZ cord-010092-uftc8inx 9901 10 considered consider VBN cord-010092-uftc8inx 9901 11 as as IN cord-010092-uftc8inx 9901 12 A A NNP cord-010092-uftc8inx 9901 13 m m NN cord-010092-uftc8inx 9901 14 . . . cord-010092-uftc8inx 9902 1 Background background NN cord-010092-uftc8inx 9902 2 : : : cord-010092-uftc8inx 9903 1 A a DT cord-010092-uftc8inx 9903 2 chimera chimera NN cord-010092-uftc8inx 9903 3 is be VBZ cord-010092-uftc8inx 9903 4 a a DT cord-010092-uftc8inx 9903 5 single single JJ cord-010092-uftc8inx 9903 6 organism organism NN cord-010092-uftc8inx 9903 7 composed compose VBN cord-010092-uftc8inx 9903 8 of of IN cord-010092-uftc8inx 9903 9 cells cell NNS cord-010092-uftc8inx 9903 10 with with IN cord-010092-uftc8inx 9903 11 distinct distinct JJ cord-010092-uftc8inx 9903 12 phenotypes phenotype NNS cord-010092-uftc8inx 9903 13 and/or and/or CC cord-010092-uftc8inx 9903 14 genotypes genotype NNS cord-010092-uftc8inx 9903 15 . . . cord-010092-uftc8inx 9904 1 Several several JJ cord-010092-uftc8inx 9904 2 different different JJ cord-010092-uftc8inx 9904 3 types type NNS cord-010092-uftc8inx 9904 4 of of IN cord-010092-uftc8inx 9904 5 chimeras chimera NNS cord-010092-uftc8inx 9904 6 are be VBP cord-010092-uftc8inx 9904 7 described describe VBN cord-010092-uftc8inx 9904 8 : : : cord-010092-uftc8inx 9904 9 artificial artificial JJ cord-010092-uftc8inx 9904 10 , , , cord-010092-uftc8inx 9904 11 twin twin JJ cord-010092-uftc8inx 9904 12 and and CC cord-010092-uftc8inx 9904 13 dispermic dispermic JJ cord-010092-uftc8inx 9904 14 . . . cord-010092-uftc8inx 9905 1 The the DT cord-010092-uftc8inx 9905 2 artificial artificial JJ cord-010092-uftc8inx 9905 3 chimerism chimerism NN cord-010092-uftc8inx 9905 4 can can MD cord-010092-uftc8inx 9905 5 be be VB cord-010092-uftc8inx 9905 6 seen see VBN cord-010092-uftc8inx 9905 7 following follow VBG cord-010092-uftc8inx 9905 8 hematopoietic hematopoietic JJ cord-010092-uftc8inx 9905 9 stem stem NN cord-010092-uftc8inx 9905 10 cell cell NN cord-010092-uftc8inx 9905 11 transplantation transplantation NN cord-010092-uftc8inx 9905 12 , , , cord-010092-uftc8inx 9905 13 or or CC cord-010092-uftc8inx 9905 14 more more RBR cord-010092-uftc8inx 9905 15 transiently transiently RB cord-010092-uftc8inx 9905 16 following follow VBG cord-010092-uftc8inx 9905 17 blood blood NN cord-010092-uftc8inx 9905 18 transfusion transfusion NN cord-010092-uftc8inx 9905 19 . . . cord-010092-uftc8inx 9906 1 The the DT cord-010092-uftc8inx 9906 2 second second JJ cord-010092-uftc8inx 9906 3 type type NN cord-010092-uftc8inx 9906 4 may may MD cord-010092-uftc8inx 9906 5 also also RB cord-010092-uftc8inx 9906 6 be be VB cord-010092-uftc8inx 9906 7 inherited inherit VBN cord-010092-uftc8inx 9906 8 most most RBS cord-010092-uftc8inx 9906 9 commonly commonly RB cord-010092-uftc8inx 9906 10 through through IN cord-010092-uftc8inx 9906 11 blood blood NN cord-010092-uftc8inx 9906 12 exchange exchange NN cord-010092-uftc8inx 9906 13 in in IN cord-010092-uftc8inx 9906 14 utero utero NN cord-010092-uftc8inx 9906 15 between between IN cord-010092-uftc8inx 9906 16 twins twin NNS cord-010092-uftc8inx 9906 17 . . . cord-010092-uftc8inx 9907 1 Dispermic dispermic JJ cord-010092-uftc8inx 9907 2 chimerism chimerism NN cord-010092-uftc8inx 9907 3 is be VBZ cord-010092-uftc8inx 9907 4 induced induce VBN cord-010092-uftc8inx 9907 5 by by IN cord-010092-uftc8inx 9907 6 the the DT cord-010092-uftc8inx 9907 7 fertilization fertilization NN cord-010092-uftc8inx 9907 8 of of IN cord-010092-uftc8inx 9907 9 two two CD cord-010092-uftc8inx 9907 10 maternal maternal JJ cord-010092-uftc8inx 9907 11 eggs egg NNS cord-010092-uftc8inx 9907 12 with with IN cord-010092-uftc8inx 9907 13 two two CD cord-010092-uftc8inx 9907 14 spermatozoa spermatozoon NNS cord-010092-uftc8inx 9907 15 and and CC cord-010092-uftc8inx 9907 16 their -PRON- PRP$ cord-010092-uftc8inx 9907 17 fusion fusion NN cord-010092-uftc8inx 9907 18 into into IN cord-010092-uftc8inx 9907 19 one one CD cord-010092-uftc8inx 9907 20 body body NN cord-010092-uftc8inx 9907 21 . . . cord-010092-uftc8inx 9908 1 This this DT cord-010092-uftc8inx 9908 2 one one NN cord-010092-uftc8inx 9908 3 is be VBZ cord-010092-uftc8inx 9908 4 also also RB cord-010092-uftc8inx 9908 5 called call VBN cord-010092-uftc8inx 9908 6 tetra tetra NNP cord-010092-uftc8inx 9908 7 - - HYPH cord-010092-uftc8inx 9908 8 gametic gametic JJ cord-010092-uftc8inx 9908 9 chimerism chimerism NN cord-010092-uftc8inx 9908 10 . . . cord-010092-uftc8inx 9909 1 In in IN cord-010092-uftc8inx 9909 2 transfusion transfusion NN cord-010092-uftc8inx 9909 3 medicine medicine NN cord-010092-uftc8inx 9909 4 , , , cord-010092-uftc8inx 9909 5 chimeras chimera NNS cord-010092-uftc8inx 9909 6 are be VBP cord-010092-uftc8inx 9909 7 often often RB cord-010092-uftc8inx 9909 8 detected detect VBN cord-010092-uftc8inx 9909 9 when when WRB cord-010092-uftc8inx 9909 10 mixed mixed JJ cord-010092-uftc8inx 9909 11 field field NN cord-010092-uftc8inx 9909 12 reactivity reactivity NN cord-010092-uftc8inx 9909 13 is be VBZ cord-010092-uftc8inx 9909 14 observed observe VBN cord-010092-uftc8inx 9909 15 in in IN cord-010092-uftc8inx 9909 16 ABO ABO NNP cord-010092-uftc8inx 9909 17 / / SYM cord-010092-uftc8inx 9909 18 D d NN cord-010092-uftc8inx 9909 19 typing typing NN cord-010092-uftc8inx 9909 20 or or CC cord-010092-uftc8inx 9909 21 , , , cord-010092-uftc8inx 9909 22 less less RBR cord-010092-uftc8inx 9909 23 commonly commonly RB cord-010092-uftc8inx 9909 24 , , , cord-010092-uftc8inx 9909 25 when when WRB cord-010092-uftc8inx 9909 26 phenotyping phenotype VBG cord-010092-uftc8inx 9909 27 for for IN cord-010092-uftc8inx 9909 28 other other JJ cord-010092-uftc8inx 9909 29 blood blood NN cord-010092-uftc8inx 9909 30 group group NN cord-010092-uftc8inx 9909 31 antigens antigen NNS cord-010092-uftc8inx 9909 32 . . . cord-010092-uftc8inx 9910 1 Aims aim VBZ cord-010092-uftc8inx 9910 2 : : : cord-010092-uftc8inx 9911 1 This this DT cord-010092-uftc8inx 9911 2 investigation investigation NN cord-010092-uftc8inx 9911 3 was be VBD cord-010092-uftc8inx 9911 4 prompted prompt VBN cord-010092-uftc8inx 9911 5 by by IN cord-010092-uftc8inx 9911 6 finding find VBG cord-010092-uftc8inx 9911 7 a a DT cord-010092-uftc8inx 9911 8 double double JJ cord-010092-uftc8inx 9911 9 population population NN cord-010092-uftc8inx 9911 10 of of IN cord-010092-uftc8inx 9911 11 erythrocytes erythrocyte NNS cord-010092-uftc8inx 9911 12 in in IN cord-010092-uftc8inx 9911 13 a a DT cord-010092-uftc8inx 9911 14 surgery surgery NN cord-010092-uftc8inx 9911 15 patient patient NN cord-010092-uftc8inx 9911 16 with with IN cord-010092-uftc8inx 9911 17 no no DT cord-010092-uftc8inx 9911 18 transfusion transfusion NN cord-010092-uftc8inx 9911 19 history history NN cord-010092-uftc8inx 9911 20 . . . cord-010092-uftc8inx 9912 1 Our -PRON- PRP$ cord-010092-uftc8inx 9912 2 aim aim NN cord-010092-uftc8inx 9912 3 was be VBD cord-010092-uftc8inx 9912 4 to to TO cord-010092-uftc8inx 9912 5 investigate investigate VB cord-010092-uftc8inx 9912 6 the the DT cord-010092-uftc8inx 9912 7 chimera chimera NN cord-010092-uftc8inx 9912 8 and and CC cord-010092-uftc8inx 9912 9 determine determine VB cord-010092-uftc8inx 9912 10 the the DT cord-010092-uftc8inx 9912 11 underlying underlie VBG cord-010092-uftc8inx 9912 12 ABO ABO NNP cord-010092-uftc8inx 9912 13 genotype genotype NN cord-010092-uftc8inx 9912 14 of of IN cord-010092-uftc8inx 9912 15 this this DT cord-010092-uftc8inx 9912 16 patient patient NN cord-010092-uftc8inx 9912 17 . . . cord-010092-uftc8inx 9913 1 Methods method NNS cord-010092-uftc8inx 9913 2 : : : cord-010092-uftc8inx 9913 3 Routine routine JJ cord-010092-uftc8inx 9913 4 blood blood NN cord-010092-uftc8inx 9913 5 grouping grouping NN cord-010092-uftc8inx 9913 6 was be VBD cord-010092-uftc8inx 9913 7 performed perform VBN cord-010092-uftc8inx 9913 8 by by IN cord-010092-uftc8inx 9913 9 column column NN cord-010092-uftc8inx 9913 10 agglutination agglutination NN cord-010092-uftc8inx 9913 11 . . . cord-010092-uftc8inx 9914 1 Separation separation NN cord-010092-uftc8inx 9914 2 of of IN cord-010092-uftc8inx 9914 3 the the DT cord-010092-uftc8inx 9914 4 double double JJ cord-010092-uftc8inx 9914 5 cell cell NN cord-010092-uftc8inx 9914 6 populations population NNS cord-010092-uftc8inx 9914 7 was be VBD cord-010092-uftc8inx 9914 8 performed perform VBN cord-010092-uftc8inx 9914 9 by by IN cord-010092-uftc8inx 9914 10 differential differential JJ cord-010092-uftc8inx 9914 11 agglutination agglutination NN cord-010092-uftc8inx 9914 12 with with IN cord-010092-uftc8inx 9914 13 IgM IgM NNP cord-010092-uftc8inx 9914 14 anti anti NNP cord-010092-uftc8inx 9914 15 - - NNP cord-010092-uftc8inx 9914 16 D d JJ cord-010092-uftc8inx 9914 17 ( ( -LRB- cord-010092-uftc8inx 9914 18 immuClone immuclone NN cord-010092-uftc8inx 9914 19 , , , cord-010092-uftc8inx 9914 20 anti anti JJ cord-010092-uftc8inx 9914 21 - - JJ cord-010092-uftc8inx 9914 22 D d JJ cord-010092-uftc8inx 9914 23 fast fast NNP cord-010092-uftc8inx 9914 24 IgM IgM NNP cord-010092-uftc8inx 9914 25 , , , cord-010092-uftc8inx 9914 26 clone clone NNP cord-010092-uftc8inx 9914 27 : : : cord-010092-uftc8inx 9914 28 D175 D175 NNP cord-010092-uftc8inx 9914 29 - - HYPH cord-010092-uftc8inx 9914 30 2 2 CD cord-010092-uftc8inx 9914 31 , , , cord-010092-uftc8inx 9914 32 Immucor Immucor NNP cord-010092-uftc8inx 9914 33 ) ) -RRB- cord-010092-uftc8inx 9914 34 . . . cord-010092-uftc8inx 9915 1 Initial initial JJ cord-010092-uftc8inx 9915 2 ABO ABO NNP cord-010092-uftc8inx 9915 3 genotyping genotyping NN cord-010092-uftc8inx 9915 4 was be VBD cord-010092-uftc8inx 9915 5 performed perform VBN cord-010092-uftc8inx 9915 6 by by IN cord-010092-uftc8inx 9915 7 PCR PCR NNP cord-010092-uftc8inx 9915 8 - - HYPH cord-010092-uftc8inx 9915 9 SSP SSP NNP cord-010092-uftc8inx 9915 10 ( ( -LRB- cord-010092-uftc8inx 9915 11 FluoGene FluoGene NNP cord-010092-uftc8inx 9915 12 ; ; : cord-010092-uftc8inx 9915 13 Inno inno JJ cord-010092-uftc8inx 9915 14 - - HYPH cord-010092-uftc8inx 9915 15 train train NN cord-010092-uftc8inx 9915 16 Diagnostik Diagnostik NNP cord-010092-uftc8inx 9915 17 GmbH GmbH NNP cord-010092-uftc8inx 9915 18 ) ) -RRB- cord-010092-uftc8inx 9915 19 ; ; : cord-010092-uftc8inx 9915 20 further further JJ cord-010092-uftc8inx 9915 21 resolution resolution NN cord-010092-uftc8inx 9915 22 was be VBD cord-010092-uftc8inx 9915 23 performed perform VBN cord-010092-uftc8inx 9915 24 using use VBG cord-010092-uftc8inx 9915 25 in in IN cord-010092-uftc8inx 9915 26 - - HYPH cord-010092-uftc8inx 9915 27 house house NN cord-010092-uftc8inx 9915 28 PCR PCR NNP cord-010092-uftc8inx 9915 29 - - HYPH cord-010092-uftc8inx 9915 30 ASP ASP NNP cord-010092-uftc8inx 9915 31 and and CC cord-010092-uftc8inx 9915 32 PCR PCR NNP cord-010092-uftc8inx 9915 33 - - HYPH cord-010092-uftc8inx 9915 34 RFLP rflp JJ cord-010092-uftc8inx 9915 35 methods method NNS cord-010092-uftc8inx 9915 36 . . . cord-010092-uftc8inx 9916 1 Next next JJ cord-010092-uftc8inx 9916 2 generation generation NN cord-010092-uftc8inx 9916 3 sequencing sequencing NN cord-010092-uftc8inx 9916 4 ( ( -LRB- cord-010092-uftc8inx 9916 5 Monotype Monotype NNP cord-010092-uftc8inx 9916 6 ABO ABO NNP cord-010092-uftc8inx 9916 7 ; ; . cord-010092-uftc8inx 9917 1 Omixon Omixon NNP cord-010092-uftc8inx 9917 2 using use VBG cord-010092-uftc8inx 9917 3 Illumina Illumina NNP cord-010092-uftc8inx 9917 4 sequencing sequencing NN cord-010092-uftc8inx 9917 5 platform platform NN cord-010092-uftc8inx 9917 6 ) ) -RRB- cord-010092-uftc8inx 9917 7 and and CC cord-010092-uftc8inx 9917 8 Sanger Sanger NNP cord-010092-uftc8inx 9917 9 sequencing sequencing NN cord-010092-uftc8inx 9917 10 analysis analysis NN cord-010092-uftc8inx 9917 11 were be VBD cord-010092-uftc8inx 9917 12 also also RB cord-010092-uftc8inx 9917 13 performed perform VBN cord-010092-uftc8inx 9917 14 . . . cord-010092-uftc8inx 9918 1 Identification identification NN cord-010092-uftc8inx 9918 2 of of IN cord-010092-uftc8inx 9918 3 reference reference NN cord-010092-uftc8inx 9918 4 alleles allele NNS cord-010092-uftc8inx 9918 5 was be VBD cord-010092-uftc8inx 9918 6 investigated investigate VBN cord-010092-uftc8inx 9918 7 by by IN cord-010092-uftc8inx 9918 8 fragment fragment NN cord-010092-uftc8inx 9918 9 analysis analysis NN cord-010092-uftc8inx 9918 10 of of IN cord-010092-uftc8inx 9918 11 Short Short NNP cord-010092-uftc8inx 9918 12 Tandem Tandem NNP cord-010092-uftc8inx 9918 13 Repeats Repeats NNP cord-010092-uftc8inx 9918 14 ( ( -LRB- cord-010092-uftc8inx 9918 15 STR str NN cord-010092-uftc8inx 9918 16 ) ) -RRB- cord-010092-uftc8inx 9918 17 polymorphisms polymorphism NNS cord-010092-uftc8inx 9918 18 . . . cord-010092-uftc8inx 9919 1 Results result NNS cord-010092-uftc8inx 9919 2 : : : cord-010092-uftc8inx 9920 1 Double double JJ cord-010092-uftc8inx 9920 2 population population NN cord-010092-uftc8inx 9920 3 was be VBD cord-010092-uftc8inx 9920 4 found find VBN cord-010092-uftc8inx 9920 5 in in IN cord-010092-uftc8inx 9920 6 column column NN cord-010092-uftc8inx 9920 7 agglutination agglutination NN cord-010092-uftc8inx 9920 8 in in IN cord-010092-uftc8inx 9920 9 tests test NNS cord-010092-uftc8inx 9920 10 with with IN cord-010092-uftc8inx 9920 11 anti anti JJ cord-010092-uftc8inx 9920 12 - - JJ cord-010092-uftc8inx 9920 13 A a JJ cord-010092-uftc8inx 9920 14 and and CC cord-010092-uftc8inx 9920 15 anti anti JJ cord-010092-uftc8inx 9920 16 - - JJ cord-010092-uftc8inx 9920 17 AB ab NN cord-010092-uftc8inx 9920 18 , , , cord-010092-uftc8inx 9920 19 and and CC cord-010092-uftc8inx 9920 20 subsequently subsequently RB cord-010092-uftc8inx 9920 21 when when WRB cord-010092-uftc8inx 9920 22 typing type VBG cord-010092-uftc8inx 9920 23 for for IN cord-010092-uftc8inx 9920 24 D D NNP cord-010092-uftc8inx 9920 25 and and CC cord-010092-uftc8inx 9920 26 C c NN cord-010092-uftc8inx 9920 27 antigens antigen NNS cord-010092-uftc8inx 9920 28 , , , cord-010092-uftc8inx 9920 29 with with IN cord-010092-uftc8inx 9920 30 approximately approximately RB cord-010092-uftc8inx 9920 31 85 85 CD cord-010092-uftc8inx 9920 32 % % NN cord-010092-uftc8inx 9920 33 of of IN cord-010092-uftc8inx 9920 34 O o NN cord-010092-uftc8inx 9920 35 D+C+ d+c+ NN cord-010092-uftc8inx 9920 36 cells cell NNS cord-010092-uftc8inx 9920 37 . . . cord-010092-uftc8inx 9921 1 The the DT cord-010092-uftc8inx 9921 2 patient patient NN cord-010092-uftc8inx 9921 3 's 's POS cord-010092-uftc8inx 9921 4 genotype genotype NN cord-010092-uftc8inx 9921 5 was be VBD cord-010092-uftc8inx 9921 6 identified identify VBN cord-010092-uftc8inx 9921 7 as as IN cord-010092-uftc8inx 9921 8 ABO*O.01/*A abo*o.01/*a NN cord-010092-uftc8inx 9921 9 by by IN cord-010092-uftc8inx 9921 10 CE CE NNP cord-010092-uftc8inx 9921 11 - - HYPH cord-010092-uftc8inx 9921 12 certified certify VBN cord-010092-uftc8inx 9921 13 PCR PCR NNP cord-010092-uftc8inx 9921 14 - - HYPH cord-010092-uftc8inx 9921 15 SSP SSP NNP cord-010092-uftc8inx 9921 16 kit kit NN cord-010092-uftc8inx 9921 17 ( ( -LRB- cord-010092-uftc8inx 9921 18 FluoGene FluoGene NNP cord-010092-uftc8inx 9921 19 ) ) -RRB- cord-010092-uftc8inx 9921 20 . . . cord-010092-uftc8inx 9922 1 Routine routine JJ cord-010092-uftc8inx 9922 2 PCR PCR NNP cord-010092-uftc8inx 9922 3 - - HYPH cord-010092-uftc8inx 9922 4 ASP ASP NNP cord-010092-uftc8inx 9922 5 and and CC cord-010092-uftc8inx 9922 6 PCR PCR NNP cord-010092-uftc8inx 9922 7 - - HYPH cord-010092-uftc8inx 9922 8 RFLP RFLP NNP cord-010092-uftc8inx 9922 9 could could MD cord-010092-uftc8inx 9922 10 not not RB cord-010092-uftc8inx 9922 11 resolve resolve VB cord-010092-uftc8inx 9922 12 the the DT cord-010092-uftc8inx 9922 13 patient patient NN cord-010092-uftc8inx 9922 14 's 's POS cord-010092-uftc8inx 9922 15 genotype genotype NN cord-010092-uftc8inx 9922 16 Possible possible JJ cord-010092-uftc8inx 9922 17 ABO*A1/*O1 ABO*A1/*O1 NNP cord-010092-uftc8inx 9922 18 genotype genotype NN cord-010092-uftc8inx 9922 19 was be VBD cord-010092-uftc8inx 9922 20 detected detect VBN cord-010092-uftc8inx 9922 21 by by IN cord-010092-uftc8inx 9922 22 PCR PCR NNP cord-010092-uftc8inx 9922 23 - - HYPH cord-010092-uftc8inx 9922 24 RFLP RFLP NNP cord-010092-uftc8inx 9922 25 , , , cord-010092-uftc8inx 9922 26 but but CC cord-010092-uftc8inx 9922 27 the the DT cord-010092-uftc8inx 9922 28 PCR PCR NNP cord-010092-uftc8inx 9922 29 - - HYPH cord-010092-uftc8inx 9922 30 ASP ASP NNP cord-010092-uftc8inx 9922 31 analysis analysis NN cord-010092-uftc8inx 9922 32 gave give VBD cord-010092-uftc8inx 9922 33 an an DT cord-010092-uftc8inx 9922 34 apparent apparent JJ cord-010092-uftc8inx 9922 35 ABO*A1 abo*a1 CD cord-010092-uftc8inx 9922 36 homozygote homozygote NN cord-010092-uftc8inx 9922 37 result result NN cord-010092-uftc8inx 9922 38 . . . cord-010092-uftc8inx 9923 1 Sanger Sanger NNP cord-010092-uftc8inx 9923 2 sequencing sequencing NN cord-010092-uftc8inx 9923 3 of of IN cord-010092-uftc8inx 9923 4 ABO ABO NNP cord-010092-uftc8inx 9923 5 exons exon NNS cord-010092-uftc8inx 9923 6 6 6 CD cord-010092-uftc8inx 9923 7 and and CC cord-010092-uftc8inx 9923 8 7 7 CD cord-010092-uftc8inx 9923 9 also also RB cord-010092-uftc8inx 9923 10 gave give VBD cord-010092-uftc8inx 9923 11 anomalous anomalous JJ cord-010092-uftc8inx 9923 12 reactions reaction NNS cord-010092-uftc8inx 9923 13 : : : cord-010092-uftc8inx 9923 14 no no DT cord-010092-uftc8inx 9923 15 ABO*A ABO*A NNP cord-010092-uftc8inx 9923 16 allele allele NN cord-010092-uftc8inx 9923 17 was be VBD cord-010092-uftc8inx 9923 18 detected detect VBN cord-010092-uftc8inx 9923 19 . . . cord-010092-uftc8inx 9924 1 Homozygosity Homozygosity NNP cord-010092-uftc8inx 9924 2 for for IN cord-010092-uftc8inx 9924 3 c.261delG c.261delg CD cord-010092-uftc8inx 9924 4 was be VBD cord-010092-uftc8inx 9924 5 observed observe VBN cord-010092-uftc8inx 9924 6 as as RB cord-010092-uftc8inx 9924 7 well well RB cord-010092-uftc8inx 9924 8 as as IN cord-010092-uftc8inx 9924 9 heterozygosity heterozygosity NN cord-010092-uftc8inx 9924 10 for for IN cord-010092-uftc8inx 9924 11 c768C c768C NNP cord-010092-uftc8inx 9924 12 / / SYM cord-010092-uftc8inx 9924 13 A. a. NN cord-010092-uftc8inx 9925 1 This this DT cord-010092-uftc8inx 9925 2 result result NN cord-010092-uftc8inx 9925 3 therefore therefore RB cord-010092-uftc8inx 9925 4 suggests suggest VBZ cord-010092-uftc8inx 9925 5 the the DT cord-010092-uftc8inx 9925 6 patient patient NN cord-010092-uftc8inx 9925 7 's 's POS cord-010092-uftc8inx 9925 8 genotype genotype NN cord-010092-uftc8inx 9925 9 is be VBZ cord-010092-uftc8inx 9925 10 ABO*O.01/*O.01.26 abo*o.01/*o.01.26 JJ cord-010092-uftc8inx 9925 11 . . . cord-010092-uftc8inx 9926 1 Next next JJ cord-010092-uftc8inx 9926 2 generation generation NN cord-010092-uftc8inx 9926 3 sequencing sequencing NN cord-010092-uftc8inx 9926 4 ( ( -LRB- cord-010092-uftc8inx 9926 5 Omixon Omixon NNP cord-010092-uftc8inx 9926 6 ) ) -RRB- cord-010092-uftc8inx 9926 7 revealed reveal VBD cord-010092-uftc8inx 9926 8 the the DT cord-010092-uftc8inx 9926 9 same same JJ cord-010092-uftc8inx 9926 10 result result NN cord-010092-uftc8inx 9926 11 . . . cord-010092-uftc8inx 9927 1 However however RB cord-010092-uftc8inx 9927 2 , , , cord-010092-uftc8inx 9927 3 when when WRB cord-010092-uftc8inx 9927 4 PCR PCR NNP cord-010092-uftc8inx 9927 5 amplification amplification NN cord-010092-uftc8inx 9927 6 of of IN cord-010092-uftc8inx 9927 7 the the DT cord-010092-uftc8inx 9927 8 CBF CBF NNP cord-010092-uftc8inx 9927 9 / / SYM cord-010092-uftc8inx 9927 10 NF NF NNP cord-010092-uftc8inx 9927 11 - - HYPH cord-010092-uftc8inx 9927 12 Y Y NNP cord-010092-uftc8inx 9927 13 enhancer enhancer NN cord-010092-uftc8inx 9927 14 VNTR vntr NN cord-010092-uftc8inx 9927 15 3 3 CD cord-010092-uftc8inx 9927 16 0 0 CD cord-010092-uftc8inx 9927 17 -region -region : cord-010092-uftc8inx 9927 18 was be VBD cord-010092-uftc8inx 9927 19 performed perform VBN cord-010092-uftc8inx 9927 20 , , , cord-010092-uftc8inx 9927 21 possible possible JJ cord-010092-uftc8inx 9927 22 heterozygosity heterozygosity NN cord-010092-uftc8inx 9927 23 was be VBD cord-010092-uftc8inx 9927 24 observed observe VBN cord-010092-uftc8inx 9927 25 , , , cord-010092-uftc8inx 9927 26 i.e. i.e. FW cord-010092-uftc8inx 9927 27 a a DT cord-010092-uftc8inx 9927 28 weak weak JJ cord-010092-uftc8inx 9927 29 band band NN cord-010092-uftc8inx 9927 30 representing represent VBG cord-010092-uftc8inx 9927 31 a a DT cord-010092-uftc8inx 9927 32 single single JJ cord-010092-uftc8inx 9927 33 copy copy NN cord-010092-uftc8inx 9927 34 , , , cord-010092-uftc8inx 9927 35 and and CC cord-010092-uftc8inx 9927 36 one one CD cord-010092-uftc8inx 9927 37 representing represent VBG cord-010092-uftc8inx 9927 38 4 4 CD cord-010092-uftc8inx 9927 39 copies copy NNS cord-010092-uftc8inx 9927 40 of of IN cord-010092-uftc8inx 9927 41 the the DT cord-010092-uftc8inx 9927 42 enhancer enhancer NN cord-010092-uftc8inx 9927 43 region region NN cord-010092-uftc8inx 9927 44 were be VBD cord-010092-uftc8inx 9927 45 present present JJ cord-010092-uftc8inx 9927 46 . . . cord-010092-uftc8inx 9928 1 Presence presence NN cord-010092-uftc8inx 9928 2 of of IN cord-010092-uftc8inx 9928 3 a a DT cord-010092-uftc8inx 9928 4 single single JJ cord-010092-uftc8inx 9928 5 copy copy NN cord-010092-uftc8inx 9928 6 of of IN cord-010092-uftc8inx 9928 7 the the DT cord-010092-uftc8inx 9928 8 43-bp 43-bp CD cord-010092-uftc8inx 9928 9 CBF CBF NNP cord-010092-uftc8inx 9928 10 / / SYM cord-010092-uftc8inx 9928 11 NF NF NNP cord-010092-uftc8inx 9928 12 - - HYPH cord-010092-uftc8inx 9928 13 Y Y NNP cord-010092-uftc8inx 9928 14 enhancer enhancer NN cord-010092-uftc8inx 9928 15 VNTR vntr NN cord-010092-uftc8inx 9928 16 region region NN cord-010092-uftc8inx 9928 17 is be VBZ cord-010092-uftc8inx 9928 18 unique unique JJ cord-010092-uftc8inx 9928 19 Background background NN cord-010092-uftc8inx 9928 20 : : : cord-010092-uftc8inx 9928 21 DEL DEL NNP cord-010092-uftc8inx 9928 22 is be VBZ cord-010092-uftc8inx 9928 23 a a DT cord-010092-uftc8inx 9928 24 very very RB cord-010092-uftc8inx 9928 25 weak weak JJ cord-010092-uftc8inx 9928 26 form form NN cord-010092-uftc8inx 9928 27 of of IN cord-010092-uftc8inx 9928 28 D d NN cord-010092-uftc8inx 9928 29 antigen antigen NN cord-010092-uftc8inx 9928 30 with with IN cord-010092-uftc8inx 9928 31 low low JJ cord-010092-uftc8inx 9928 32 density density NN cord-010092-uftc8inx 9928 33 expression expression NN cord-010092-uftc8inx 9928 34 of of IN cord-010092-uftc8inx 9928 35 D d NN cord-010092-uftc8inx 9928 36 antigen antigen NN cord-010092-uftc8inx 9928 37 on on IN cord-010092-uftc8inx 9928 38 the the DT cord-010092-uftc8inx 9928 39 surface surface NN cord-010092-uftc8inx 9928 40 of of IN cord-010092-uftc8inx 9928 41 red red JJ cord-010092-uftc8inx 9928 42 blood blood NN cord-010092-uftc8inx 9928 43 cell cell NN cord-010092-uftc8inx 9928 44 , , , cord-010092-uftc8inx 9928 45 which which WDT cord-010092-uftc8inx 9928 46 is be VBZ cord-010092-uftc8inx 9928 47 generally generally RB cord-010092-uftc8inx 9928 48 typed type VBN cord-010092-uftc8inx 9928 49 as as IN cord-010092-uftc8inx 9928 50 D d NN cord-010092-uftc8inx 9928 51 - - HYPH cord-010092-uftc8inx 9928 52 blood blood NN cord-010092-uftc8inx 9928 53 group group NN cord-010092-uftc8inx 9928 54 as as IN cord-010092-uftc8inx 9928 55 could could MD cord-010092-uftc8inx 9928 56 n't not RB cord-010092-uftc8inx 9928 57 form form VB cord-010092-uftc8inx 9928 58 agglutination agglutination NN cord-010092-uftc8inx 9928 59 in in IN cord-010092-uftc8inx 9928 60 routine routine JJ cord-010092-uftc8inx 9928 61 RhD rhd NN cord-010092-uftc8inx 9928 62 blood blood NN cord-010092-uftc8inx 9928 63 group group NN cord-010092-uftc8inx 9928 64 testing testing NN cord-010092-uftc8inx 9928 65 and and CC cord-010092-uftc8inx 9928 66 could could MD cord-010092-uftc8inx 9928 67 only only RB cord-010092-uftc8inx 9928 68 be be VB cord-010092-uftc8inx 9928 69 detected detect VBN cord-010092-uftc8inx 9928 70 by by IN cord-010092-uftc8inx 9928 71 the the DT cord-010092-uftc8inx 9928 72 non non JJ cord-010092-uftc8inx 9928 73 - - JJ cord-010092-uftc8inx 9928 74 routine routine JJ cord-010092-uftc8inx 9928 75 adsorption adsorption NN cord-010092-uftc8inx 9928 76 - - HYPH cord-010092-uftc8inx 9928 77 elution elution NN cord-010092-uftc8inx 9928 78 test test NN cord-010092-uftc8inx 9928 79 . . . cord-010092-uftc8inx 9929 1 In in IN cord-010092-uftc8inx 9929 2 the the DT cord-010092-uftc8inx 9929 3 East east JJ cord-010092-uftc8inx 9929 4 Asian Asian NNP cord-010092-uftc8inx 9929 5 and and CC cord-010092-uftc8inx 9929 6 Southeast southeast JJ cord-010092-uftc8inx 9929 7 Asian asian JJ cord-010092-uftc8inx 9929 8 population population NN cord-010092-uftc8inx 9929 9 , , , cord-010092-uftc8inx 9929 10 9 9 CD cord-010092-uftc8inx 9929 11 - - SYM cord-010092-uftc8inx 9929 12 30 30 CD cord-010092-uftc8inx 9929 13 % % NN cord-010092-uftc8inx 9929 14 of of IN cord-010092-uftc8inx 9929 15 the the DT cord-010092-uftc8inx 9929 16 individuals individual NNS cord-010092-uftc8inx 9929 17 with with IN cord-010092-uftc8inx 9929 18 serologically serologically RB cord-010092-uftc8inx 9929 19 apparent apparent JJ cord-010092-uftc8inx 9929 20 D d NN cord-010092-uftc8inx 9929 21 - - HYPH cord-010092-uftc8inx 9929 22 phenotype phenotype NN cord-010092-uftc8inx 9929 23 are be VBP cord-010092-uftc8inx 9929 24 not not RB cord-010092-uftc8inx 9929 25 these these DT cord-010092-uftc8inx 9929 26 with with IN cord-010092-uftc8inx 9929 27 truly truly RB cord-010092-uftc8inx 9929 28 D d NN cord-010092-uftc8inx 9929 29 - - HYPH cord-010092-uftc8inx 9929 30 phenotype phenotype NN cord-010092-uftc8inx 9929 31 , , , cord-010092-uftc8inx 9929 32 but but CC cord-010092-uftc8inx 9929 33 DEL DEL NNP cord-010092-uftc8inx 9929 34 phenotype phenotype NN cord-010092-uftc8inx 9929 35 , , , cord-010092-uftc8inx 9929 36 which which WDT cord-010092-uftc8inx 9929 37 is be VBZ cord-010092-uftc8inx 9929 38 very very RB cord-010092-uftc8inx 9929 39 rare rare JJ cord-010092-uftc8inx 9929 40 in in IN cord-010092-uftc8inx 9929 41 Caucasian caucasian JJ cord-010092-uftc8inx 9929 42 and and CC cord-010092-uftc8inx 9929 43 Black black JJ cord-010092-uftc8inx 9929 44 ethic ethic NN cord-010092-uftc8inx 9929 45 groups group NNS cord-010092-uftc8inx 9929 46 . . . cord-010092-uftc8inx 9930 1 And and CC cord-010092-uftc8inx 9930 2 the the DT cord-010092-uftc8inx 9930 3 RHD*01EL.01 RHD*01EL.01 NNP cord-010092-uftc8inx 9930 4 ( ( -LRB- cord-010092-uftc8inx 9930 5 RHD*1227A RHD*1227A NNP cord-010092-uftc8inx 9930 6 ) ) -RRB- cord-010092-uftc8inx 9930 7 is be VBZ cord-010092-uftc8inx 9930 8 most most RBS cord-010092-uftc8inx 9930 9 prevalent prevalent JJ cord-010092-uftc8inx 9930 10 ( ( -LRB- cord-010092-uftc8inx 9930 11 > > NFP cord-010092-uftc8inx 9930 12 99 99 CD cord-010092-uftc8inx 9930 13 % % NN cord-010092-uftc8inx 9930 14 ) ) -RRB- cord-010092-uftc8inx 9930 15 in in IN cord-010092-uftc8inx 9930 16 DEL DEL NNP cord-010092-uftc8inx 9930 17 people people NNS cord-010092-uftc8inx 9930 18 in in IN cord-010092-uftc8inx 9930 19 these these DT cord-010092-uftc8inx 9930 20 regions region NNS cord-010092-uftc8inx 9930 21 , , , cord-010092-uftc8inx 9930 22 so so IN cord-010092-uftc8inx 9930 23 the the DT cord-010092-uftc8inx 9930 24 DEL DEL NNP cord-010092-uftc8inx 9930 25 carried carry VBD cord-010092-uftc8inx 9930 26 this this DT cord-010092-uftc8inx 9930 27 allele allele NN cord-010092-uftc8inx 9930 28 was be VBD cord-010092-uftc8inx 9930 29 commonly commonly RB cord-010092-uftc8inx 9930 30 known know VBN cord-010092-uftc8inx 9930 31 as as IN cord-010092-uftc8inx 9930 32 " " `` cord-010092-uftc8inx 9930 33 Asia Asia NNP cord-010092-uftc8inx 9930 34 type type NN cord-010092-uftc8inx 9930 35 " " '' cord-010092-uftc8inx 9930 36 DEL DEL NNP cord-010092-uftc8inx 9930 37 . . . cord-010092-uftc8inx 9931 1 In in IN cord-010092-uftc8inx 9931 2 previous previous JJ cord-010092-uftc8inx 9931 3 studies study NNS cord-010092-uftc8inx 9931 4 , , , cord-010092-uftc8inx 9931 5 no no DT cord-010092-uftc8inx 9931 6 alloanti alloanti NNP cord-010092-uftc8inx 9931 7 - - HYPH cord-010092-uftc8inx 9931 8 D D NNP cord-010092-uftc8inx 9931 9 was be VBD cord-010092-uftc8inx 9931 10 observed observe VBN cord-010092-uftc8inx 9931 11 in in IN cord-010092-uftc8inx 9931 12 a a DT cord-010092-uftc8inx 9931 13 large large JJ cord-010092-uftc8inx 9931 14 cohort cohort NN cord-010092-uftc8inx 9931 15 of of IN cord-010092-uftc8inx 9931 16 Chinese chinese JJ cord-010092-uftc8inx 9931 17 " " `` cord-010092-uftc8inx 9931 18 Asia Asia NNP cord-010092-uftc8inx 9931 19 type type NN cord-010092-uftc8inx 9931 20 " " '' cord-010092-uftc8inx 9931 21 DEL DEL NNP cord-010092-uftc8inx 9931 22 pregnant pregnant JJ cord-010092-uftc8inx 9931 23 women woman NNS cord-010092-uftc8inx 9931 24 with with IN cord-010092-uftc8inx 9931 25 D+ d+ NN cord-010092-uftc8inx 9931 26 fetus fetus NN cord-010092-uftc8inx 9931 27 to to TO cord-010092-uftc8inx 9931 28 indicate indicate VB cord-010092-uftc8inx 9931 29 no no DT cord-010092-uftc8inx 9931 30 occurrence occurrence NN cord-010092-uftc8inx 9931 31 of of IN cord-010092-uftc8inx 9931 32 alloanti alloanti NNP cord-010092-uftc8inx 9931 33 - - HYPH cord-010092-uftc8inx 9931 34 D d NN cord-010092-uftc8inx 9931 35 immunization immunization NN cord-010092-uftc8inx 9931 36 against against IN cord-010092-uftc8inx 9931 37 D+ D+ NNP cord-010092-uftc8inx 9931 38 red red JJ cord-010092-uftc8inx 9931 39 cell cell NN cord-010092-uftc8inx 9931 40 in in IN cord-010092-uftc8inx 9931 41 " " `` cord-010092-uftc8inx 9931 42 Asia Asia NNP cord-010092-uftc8inx 9931 43 type type NN cord-010092-uftc8inx 9931 44 " " '' cord-010092-uftc8inx 9931 45 DEL DEL NNP cord-010092-uftc8inx 9931 46 individuals individual NNS cord-010092-uftc8inx 9931 47 . . . cord-010092-uftc8inx 9932 1 Aims aim VBZ cord-010092-uftc8inx 9932 2 : : : cord-010092-uftc8inx 9933 1 To to TO cord-010092-uftc8inx 9933 2 conduct conduct VB cord-010092-uftc8inx 9933 3 genotyping genotyping NN cord-010092-uftc8inx 9933 4 analysis analysis NN cord-010092-uftc8inx 9933 5 in in IN cord-010092-uftc8inx 9933 6 the the DT cord-010092-uftc8inx 9933 7 Chinese chinese JJ cord-010092-uftc8inx 9933 8 patients patient NNS cord-010092-uftc8inx 9933 9 having have VBG cord-010092-uftc8inx 9933 10 serologically serologically RB cord-010092-uftc8inx 9933 11 apparent apparent JJ cord-010092-uftc8inx 9933 12 D d NN cord-010092-uftc8inx 9933 13 - - HYPH cord-010092-uftc8inx 9933 14 phenotype phenotype NN cord-010092-uftc8inx 9933 15 simultaneous simultaneous JJ cord-010092-uftc8inx 9933 16 with with IN cord-010092-uftc8inx 9933 17 alloanti alloanti NNP cord-010092-uftc8inx 9933 18 - - HYPH cord-010092-uftc8inx 9933 19 D D NNP cord-010092-uftc8inx 9933 20 to to TO cord-010092-uftc8inx 9933 21 confirm confirm VB cord-010092-uftc8inx 9933 22 the the DT cord-010092-uftc8inx 9933 23 existence existence NN cord-010092-uftc8inx 9933 24 of of IN cord-010092-uftc8inx 9933 25 the the DT cord-010092-uftc8inx 9933 26 " " `` cord-010092-uftc8inx 9933 27 Asia Asia NNP cord-010092-uftc8inx 9933 28 type type NN cord-010092-uftc8inx 9933 29 " " '' cord-010092-uftc8inx 9933 30 individuals individual NNS cord-010092-uftc8inx 9933 31 to to TO cord-010092-uftc8inx 9933 32 produce produce VB cord-010092-uftc8inx 9933 33 alloanti alloanti NNS cord-010092-uftc8inx 9933 34 - - HYPH cord-010092-uftc8inx 9933 35 D D NNP cord-010092-uftc8inx 9933 36 or or CC cord-010092-uftc8inx 9933 37 not not RB cord-010092-uftc8inx 9933 38 . . . cord-010092-uftc8inx 9934 1 Methods method NNS cord-010092-uftc8inx 9934 2 : : : cord-010092-uftc8inx 9935 1 From from IN cord-010092-uftc8inx 9935 2 2017 2017 CD cord-010092-uftc8inx 9935 3 to to IN cord-010092-uftc8inx 9935 4 2018 2018 CD cord-010092-uftc8inx 9935 5 , , , cord-010092-uftc8inx 9935 6 the the DT cord-010092-uftc8inx 9935 7 blood blood NN cord-010092-uftc8inx 9935 8 sample sample NN cord-010092-uftc8inx 9935 9 of of IN cord-010092-uftc8inx 9935 10 the the DT cord-010092-uftc8inx 9935 11 patients patient NNS cord-010092-uftc8inx 9935 12 or or CC cord-010092-uftc8inx 9935 13 pregnant pregnant JJ cord-010092-uftc8inx 9935 14 women woman NNS cord-010092-uftc8inx 9935 15 identified identify VBN cord-010092-uftc8inx 9935 16 with with IN cord-010092-uftc8inx 9935 17 alloanti alloanti NNP cord-010092-uftc8inx 9935 18 - - HYPH cord-010092-uftc8inx 9935 19 D D NNP cord-010092-uftc8inx 9935 20 in in IN cord-010092-uftc8inx 9935 21 our -PRON- PRP$ cord-010092-uftc8inx 9935 22 reference reference NN cord-010092-uftc8inx 9935 23 lab lab NN cord-010092-uftc8inx 9935 24 were be VBD cord-010092-uftc8inx 9935 25 collected collect VBN cord-010092-uftc8inx 9935 26 . . . cord-010092-uftc8inx 9936 1 D D NNP cord-010092-uftc8inx 9936 2 antigen antigen NNP cord-010092-uftc8inx 9936 3 was be VBD cord-010092-uftc8inx 9936 4 confirmed confirm VBN cord-010092-uftc8inx 9936 5 again again RB cord-010092-uftc8inx 9936 6 using use VBG cord-010092-uftc8inx 9936 7 the the DT cord-010092-uftc8inx 9936 8 blend blend NN cord-010092-uftc8inx 9936 9 anti anti JJ cord-010092-uftc8inx 9936 10 - - JJ cord-010092-uftc8inx 9936 11 D d JJ cord-010092-uftc8inx 9936 12 reagent reagent NN cord-010092-uftc8inx 9936 13 ( ( -LRB- cord-010092-uftc8inx 9936 14 Clone Clone NNP cord-010092-uftc8inx 9936 15 TH-28 TH-28 NNP cord-010092-uftc8inx 9936 16 / / SYM cord-010092-uftc8inx 9936 17 MS-26 MS-26 NNP cord-010092-uftc8inx 9936 18 , , , cord-010092-uftc8inx 9936 19 IgM IgM NNP cord-010092-uftc8inx 9936 20 / / SYM cord-010092-uftc8inx 9936 21 IgG IgG NNP cord-010092-uftc8inx 9936 22 ) ) -RRB- cord-010092-uftc8inx 9936 23 by by IN cord-010092-uftc8inx 9936 24 tube tube NN cord-010092-uftc8inx 9936 25 method method NN cord-010092-uftc8inx 9936 26 in in IN cord-010092-uftc8inx 9936 27 saline saline NN cord-010092-uftc8inx 9936 28 and and CC cord-010092-uftc8inx 9936 29 indirect indirect JJ cord-010092-uftc8inx 9936 30 antiglobulin antiglobulin NN cord-010092-uftc8inx 9936 31 test test NN cord-010092-uftc8inx 9936 32 ( ( -LRB- cord-010092-uftc8inx 9936 33 IAT IAT NNP cord-010092-uftc8inx 9936 34 ) ) -RRB- cord-010092-uftc8inx 9936 35 in in IN cord-010092-uftc8inx 9936 36 gel gel NN cord-010092-uftc8inx 9936 37 card card NN cord-010092-uftc8inx 9936 38 . . . cord-010092-uftc8inx 9937 1 The the DT cord-010092-uftc8inx 9937 2 zygosity zygosity NN cord-010092-uftc8inx 9937 3 of of IN cord-010092-uftc8inx 9937 4 RHD RHD NNP cord-010092-uftc8inx 9937 5 gene gene NN cord-010092-uftc8inx 9937 6 was be VBD cord-010092-uftc8inx 9937 7 detected detect VBN cord-010092-uftc8inx 9937 8 by by IN cord-010092-uftc8inx 9937 9 hybrid hybrid JJ cord-010092-uftc8inx 9937 10 rhesus rhesu NNS cord-010092-uftc8inx 9937 11 box box NN cord-010092-uftc8inx 9937 12 PCR PCR NNP cord-010092-uftc8inx 9937 13 with with IN cord-010092-uftc8inx 9937 14 PstI PstI NNP cord-010092-uftc8inx 9937 15 digestion digestion NN cord-010092-uftc8inx 9937 16 . . . cord-010092-uftc8inx 9938 1 For for IN cord-010092-uftc8inx 9938 2 the the DT cord-010092-uftc8inx 9938 3 samples sample NNS cord-010092-uftc8inx 9938 4 with with IN cord-010092-uftc8inx 9938 5 D D NNP cord-010092-uftc8inx 9938 6 or or CC cord-010092-uftc8inx 9938 7 DD DD NNP cord-010092-uftc8inx 9938 8 genotypes genotype NNS cord-010092-uftc8inx 9938 9 obtained obtain VBN cord-010092-uftc8inx 9938 10 by by IN cord-010092-uftc8inx 9938 11 RHD RHD NNP cord-010092-uftc8inx 9938 12 zygosity zygosity NNP cord-010092-uftc8inx 9938 13 analysis analysis NN cord-010092-uftc8inx 9938 14 , , , cord-010092-uftc8inx 9938 15 multiplex multiplex JJ cord-010092-uftc8inx 9938 16 ligation ligation NN cord-010092-uftc8inx 9938 17 - - HYPH cord-010092-uftc8inx 9938 18 dependent dependent JJ cord-010092-uftc8inx 9938 19 probe probe NN cord-010092-uftc8inx 9938 20 amplification amplification NN cord-010092-uftc8inx 9938 21 ( ( -LRB- cord-010092-uftc8inx 9938 22 MLPA MLPA NNP cord-010092-uftc8inx 9938 23 ) ) -RRB- cord-010092-uftc8inx 9938 24 genotyping genotyping NN cord-010092-uftc8inx 9938 25 was be VBD cord-010092-uftc8inx 9938 26 conducted conduct VBN cord-010092-uftc8inx 9938 27 for for IN cord-010092-uftc8inx 9938 28 RHD RHD NNP cord-010092-uftc8inx 9938 29 genotyping genotyping NN cord-010092-uftc8inx 9938 30 analysis analysis NN cord-010092-uftc8inx 9938 31 . . . cord-010092-uftc8inx 9939 1 Results result NNS cord-010092-uftc8inx 9939 2 : : : cord-010092-uftc8inx 9940 1 A a DT cord-010092-uftc8inx 9940 2 total total NN cord-010092-uftc8inx 9940 3 of of IN cord-010092-uftc8inx 9940 4 129 129 CD cord-010092-uftc8inx 9940 5 serologically serologically RB cord-010092-uftc8inx 9940 6 apparent apparent JJ cord-010092-uftc8inx 9940 7 D d NN cord-010092-uftc8inx 9940 8 - - HYPH cord-010092-uftc8inx 9940 9 Chinese chinese JJ cord-010092-uftc8inx 9940 10 patients patient NNS cord-010092-uftc8inx 9940 11 ( ( -LRB- cord-010092-uftc8inx 9940 12 female female JJ cord-010092-uftc8inx 9940 13 , , , cord-010092-uftc8inx 9940 14 n n NN cord-010092-uftc8inx 9940 15 = = SYM cord-010092-uftc8inx 9940 16 128 128 CD cord-010092-uftc8inx 9940 17 ; ; : cord-010092-uftc8inx 9940 18 male male JJ cord-010092-uftc8inx 9940 19 , , , cord-010092-uftc8inx 9940 20 n n NN cord-010092-uftc8inx 9940 21 = = SYM cord-010092-uftc8inx 9940 22 1 1 CD cord-010092-uftc8inx 9940 23 ) ) -RRB- cord-010092-uftc8inx 9940 24 with with IN cord-010092-uftc8inx 9940 25 alloanti alloanti NNP cord-010092-uftc8inx 9940 26 - - HYPH cord-010092-uftc8inx 9940 27 D D NNP cord-010092-uftc8inx 9940 28 were be VBD cord-010092-uftc8inx 9940 29 identified identify VBN cord-010092-uftc8inx 9940 30 . . . cord-010092-uftc8inx 9941 1 Different different JJ cord-010092-uftc8inx 9941 2 titers titer NNS cord-010092-uftc8inx 9941 3 of of IN cord-010092-uftc8inx 9941 4 alloanti alloanti NNP cord-010092-uftc8inx 9941 5 - - HYPH cord-010092-uftc8inx 9941 6 D D NNP cord-010092-uftc8inx 9941 7 from from IN cord-010092-uftc8inx 9941 8 1:2 1:2 CD cord-010092-uftc8inx 9941 9 to to IN cord-010092-uftc8inx 9941 10 1:4096 1:4096 CD cord-010092-uftc8inx 9942 1 ( ( -LRB- cord-010092-uftc8inx 9942 2 ≤1:16 ≤1:16 NNP cord-010092-uftc8inx 9942 3 , , , cord-010092-uftc8inx 9942 4 n n NN cord-010092-uftc8inx 9942 5 = = SYM cord-010092-uftc8inx 9942 6 60 60 CD cord-010092-uftc8inx 9942 7 ; ; : cord-010092-uftc8inx 9942 8 > > NFP cord-010092-uftc8inx 9942 9 1:16 1:16 CD cord-010092-uftc8inx 9942 10 , , , cord-010092-uftc8inx 9942 11 n n NN cord-010092-uftc8inx 9942 12 = = SYM cord-010092-uftc8inx 9942 13 69 69 CD cord-010092-uftc8inx 9942 14 ) ) -RRB- cord-010092-uftc8inx 9942 15 were be VBD cord-010092-uftc8inx 9942 16 detected detect VBN cord-010092-uftc8inx 9942 17 including include VBG cord-010092-uftc8inx 9942 18 few few JJ cord-010092-uftc8inx 9942 19 cases case NNS cord-010092-uftc8inx 9942 20 with with IN cord-010092-uftc8inx 9942 21 mixed mixed JJ cord-010092-uftc8inx 9942 22 antibodies antibody NNS cord-010092-uftc8inx 9942 23 ( ( -LRB- cord-010092-uftc8inx 9942 24 anti anti JJ cord-010092-uftc8inx 9942 25 - - JJ cord-010092-uftc8inx 9942 26 D d JJ cord-010092-uftc8inx 9942 27 mixed mix VBN cord-010092-uftc8inx 9942 28 with with IN cord-010092-uftc8inx 9942 29 anti anti JJ cord-010092-uftc8inx 9942 30 - - NNP cord-010092-uftc8inx 9942 31 C C NNP cord-010092-uftc8inx 9942 32 , , , cord-010092-uftc8inx 9942 33 n n NN cord-010092-uftc8inx 9942 34 = = SYM cord-010092-uftc8inx 9942 35 11 11 CD cord-010092-uftc8inx 9942 36 ; ; : cord-010092-uftc8inx 9942 37 anti anti JJ cord-010092-uftc8inx 9942 38 - - JJ cord-010092-uftc8inx 9942 39 D d JJ cord-010092-uftc8inx 9942 40 mixed mixed JJ cord-010092-uftc8inx 9942 41 anti anti NN cord-010092-uftc8inx 9942 42 - - JJ cord-010092-uftc8inx 9942 43 E e JJ cord-010092-uftc8inx 9942 44 , , , cord-010092-uftc8inx 9942 45 n n NN cord-010092-uftc8inx 9942 46 = = SYM cord-010092-uftc8inx 9942 47 5 5 CD cord-010092-uftc8inx 9942 48 ) ) -RRB- cord-010092-uftc8inx 9942 49 . . . cord-010092-uftc8inx 9943 1 Serological serological JJ cord-010092-uftc8inx 9943 2 RhD rhd NN cord-010092-uftc8inx 9943 3 typing typing NN cord-010092-uftc8inx 9943 4 confirmed confirm VBD cord-010092-uftc8inx 9943 5 the the DT cord-010092-uftc8inx 9943 6 serologically serologically RB cord-010092-uftc8inx 9943 7 apparent apparent JJ cord-010092-uftc8inx 9943 8 D d NN cord-010092-uftc8inx 9943 9 - - HYPH cord-010092-uftc8inx 9943 10 phenotype phenotype NN cord-010092-uftc8inx 9943 11 . . . cord-010092-uftc8inx 9944 1 RHD*01N.01/01N.01 RHD*01N.01/01N.01 NNP cord-010092-uftc8inx 9944 2 ( ( -LRB- cord-010092-uftc8inx 9944 3 homozygous homozygous JJ cord-010092-uftc8inx 9944 4 RHD RHD NNP cord-010092-uftc8inx 9944 5 gene gene NN cord-010092-uftc8inx 9944 6 deletion deletion NN cord-010092-uftc8inx 9944 7 ) ) -RRB- cord-010092-uftc8inx 9944 8 genotype genotype NN cord-010092-uftc8inx 9944 9 was be VBD cord-010092-uftc8inx 9944 10 identified identify VBN cord-010092-uftc8inx 9944 11 in in IN cord-010092-uftc8inx 9944 12 majority majority NN cord-010092-uftc8inx 9944 13 of of IN cord-010092-uftc8inx 9944 14 them -PRON- PRP cord-010092-uftc8inx 9944 15 ( ( -LRB- cord-010092-uftc8inx 9944 16 123/129 123/129 CD cord-010092-uftc8inx 9944 17 , , , cord-010092-uftc8inx 9944 18 95.3 95.3 CD cord-010092-uftc8inx 9944 19 % % NN cord-010092-uftc8inx 9944 20 ) ) -RRB- cord-010092-uftc8inx 9944 21 by by IN cord-010092-uftc8inx 9944 22 RHD RHD NNP cord-010092-uftc8inx 9944 23 zygosity zygosity NNP cord-010092-uftc8inx 9944 24 analysis analysis NN cord-010092-uftc8inx 9944 25 , , , cord-010092-uftc8inx 9944 26 while while IN cord-010092-uftc8inx 9944 27 RHD*01N.03/ RHD*01N.03/ . cord-010092-uftc8inx 9944 28 01N.01 01n.01 CD cord-010092-uftc8inx 9944 29 genotype genotype NN cord-010092-uftc8inx 9944 30 ( ( -LRB- cord-010092-uftc8inx 9944 31 n n NN cord-010092-uftc8inx 9944 32 = = SYM cord-010092-uftc8inx 9944 33 5 5 CD cord-010092-uftc8inx 9944 34 ) ) -RRB- cord-010092-uftc8inx 9944 35 and and CC cord-010092-uftc8inx 9944 36 RHD*01N.05/01N.01 RHD*01N.05/01N.01 NNP cord-010092-uftc8inx 9944 37 genotype genotype NNP cord-010092-uftc8inx 9944 38 ( ( -LRB- cord-010092-uftc8inx 9944 39 n n NN cord-010092-uftc8inx 9944 40 = = SYM cord-010092-uftc8inx 9944 41 1 1 CD cord-010092-uftc8inx 9944 42 ) ) -RRB- cord-010092-uftc8inx 9944 43 carried carry VBD cord-010092-uftc8inx 9944 44 the the DT cord-010092-uftc8inx 9944 45 RHD RHD NNP cord-010092-uftc8inx 9944 46 non non JJ cord-010092-uftc8inx 9944 47 - - JJ cord-010092-uftc8inx 9944 48 functional functional JJ cord-010092-uftc8inx 9944 49 hybrid hybrid NN cord-010092-uftc8inx 9944 50 alleles allele NNS cord-010092-uftc8inx 9944 51 were be VBD cord-010092-uftc8inx 9944 52 detected detect VBN cord-010092-uftc8inx 9944 53 by by IN cord-010092-uftc8inx 9944 54 MLPA MLPA NNP cord-010092-uftc8inx 9944 55 . . . cord-010092-uftc8inx 9945 1 Summary Summary NNP cord-010092-uftc8inx 9945 2 / / SYM cord-010092-uftc8inx 9945 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 9945 4 : : : cord-010092-uftc8inx 9946 1 Compared compare VBN cord-010092-uftc8inx 9946 2 with with IN cord-010092-uftc8inx 9946 3 the the DT cord-010092-uftc8inx 9946 4 distribution distribution NN cord-010092-uftc8inx 9946 5 of of IN cord-010092-uftc8inx 9946 6 average average JJ cord-010092-uftc8inx 9946 7 25 25 CD cord-010092-uftc8inx 9946 8 % % NN cord-010092-uftc8inx 9946 9 frequency frequency NN cord-010092-uftc8inx 9946 10 of of IN cord-010092-uftc8inx 9946 11 " " `` cord-010092-uftc8inx 9946 12 Asia Asia NNP cord-010092-uftc8inx 9946 13 type type NN cord-010092-uftc8inx 9946 14 " " '' cord-010092-uftc8inx 9946 15 DEL DEL NNP cord-010092-uftc8inx 9946 16 in in IN cord-010092-uftc8inx 9946 17 serologically serologically RB cord-010092-uftc8inx 9946 18 apparent apparent JJ cord-010092-uftc8inx 9946 19 Dpopulation Dpopulation NNP cord-010092-uftc8inx 9946 20 in in IN cord-010092-uftc8inx 9946 21 Guangzhou Guangzhou NNP cord-010092-uftc8inx 9946 22 of of IN cord-010092-uftc8inx 9946 23 China China NNP cord-010092-uftc8inx 9946 24 , , , cord-010092-uftc8inx 9946 25 no no DT cord-010092-uftc8inx 9946 26 one one CD cord-010092-uftc8inx 9946 27 case case NN cord-010092-uftc8inx 9946 28 of of IN cord-010092-uftc8inx 9946 29 " " `` cord-010092-uftc8inx 9946 30 Asia Asia NNP cord-010092-uftc8inx 9946 31 type type NN cord-010092-uftc8inx 9946 32 " " '' cord-010092-uftc8inx 9946 33 DEL DEL NNP cord-010092-uftc8inx 9946 34 was be VBD cord-010092-uftc8inx 9946 35 identified identify VBN cord-010092-uftc8inx 9946 36 in in IN cord-010092-uftc8inx 9946 37 the the DT cord-010092-uftc8inx 9946 38 cohort cohort NN cord-010092-uftc8inx 9946 39 of of IN cord-010092-uftc8inx 9946 40 serologically serologically RB cord-010092-uftc8inx 9946 41 apparent apparent JJ cord-010092-uftc8inx 9946 42 D d NN cord-010092-uftc8inx 9946 43 - - HYPH cord-010092-uftc8inx 9946 44 patients patient NNS cord-010092-uftc8inx 9946 45 with with IN cord-010092-uftc8inx 9946 46 alloanti alloanti NNP cord-010092-uftc8inx 9946 47 - - HYPH cord-010092-uftc8inx 9946 48 D D NNP cord-010092-uftc8inx 9946 49 in in IN cord-010092-uftc8inx 9946 50 this this DT cord-010092-uftc8inx 9946 51 study study NN cord-010092-uftc8inx 9946 52 . . . cord-010092-uftc8inx 9947 1 This this DT cord-010092-uftc8inx 9947 2 also also RB cord-010092-uftc8inx 9947 3 provides provide VBZ cord-010092-uftc8inx 9947 4 evidence evidence NN cord-010092-uftc8inx 9947 5 to to TO cord-010092-uftc8inx 9947 6 confirm confirm VB cord-010092-uftc8inx 9947 7 no no DT cord-010092-uftc8inx 9947 8 occurrence occurrence NN cord-010092-uftc8inx 9947 9 of of IN cord-010092-uftc8inx 9947 10 alloanti alloanti NNP cord-010092-uftc8inx 9947 11 - - HYPH cord-010092-uftc8inx 9947 12 D d JJ cord-010092-uftc8inx 9947 13 immunization immunization NN cord-010092-uftc8inx 9947 14 in in IN cord-010092-uftc8inx 9947 15 " " `` cord-010092-uftc8inx 9947 16 Asia Asia NNP cord-010092-uftc8inx 9947 17 type type NN cord-010092-uftc8inx 9947 18 " " '' cord-010092-uftc8inx 9947 19 DEL DEL NNP cord-010092-uftc8inx 9947 20 individuals individual NNS cord-010092-uftc8inx 9947 21 . . . cord-010092-uftc8inx 9948 1 Aims aim VBZ cord-010092-uftc8inx 9948 2 : : : cord-010092-uftc8inx 9949 1 A a DT cord-010092-uftc8inx 9949 2 serologically serologically RB cord-010092-uftc8inx 9949 3 RhD rhd JJ cord-010092-uftc8inx 9949 4 - - HYPH cord-010092-uftc8inx 9949 5 negative negative JJ cord-010092-uftc8inx 9949 6 donor donor NN cord-010092-uftc8inx 9949 7 was be VBD cord-010092-uftc8inx 9949 8 found find VBN cord-010092-uftc8inx 9949 9 to to TO cord-010092-uftc8inx 9949 10 be be VB cord-010092-uftc8inx 9949 11 RHD RHD NNP cord-010092-uftc8inx 9949 12 - - HYPH cord-010092-uftc8inx 9949 13 positive positive JJ cord-010092-uftc8inx 9949 14 in in IN cord-010092-uftc8inx 9949 15 the the DT cord-010092-uftc8inx 9949 16 routine routine JJ cord-010092-uftc8inx 9949 17 RHD RHD NNP cord-010092-uftc8inx 9949 18 screen screen NN cord-010092-uftc8inx 9949 19 . . . cord-010092-uftc8inx 9950 1 To to TO cord-010092-uftc8inx 9950 2 solve solve VB cord-010092-uftc8inx 9950 3 the the DT cord-010092-uftc8inx 9950 4 discrepancy discrepancy NN cord-010092-uftc8inx 9950 5 between between IN cord-010092-uftc8inx 9950 6 serology serology NN cord-010092-uftc8inx 9950 7 and and CC cord-010092-uftc8inx 9950 8 molecular molecular JJ cord-010092-uftc8inx 9950 9 screen screen NN cord-010092-uftc8inx 9950 10 , , , cord-010092-uftc8inx 9950 11 the the DT cord-010092-uftc8inx 9950 12 sample sample NN cord-010092-uftc8inx 9950 13 was be VBD cord-010092-uftc8inx 9950 14 sequenced sequence VBN cord-010092-uftc8inx 9950 15 on on IN cord-010092-uftc8inx 9950 16 DNA DNA NNP cord-010092-uftc8inx 9950 17 and and CC cord-010092-uftc8inx 9950 18 RNA RNA NNP cord-010092-uftc8inx 9950 19 level level NN cord-010092-uftc8inx 9950 20 . . . cord-010092-uftc8inx 9951 1 Methods method NNS cord-010092-uftc8inx 9951 2 : : : cord-010092-uftc8inx 9951 3 Phenotyping phenotyping NN cord-010092-uftc8inx 9951 4 on on IN cord-010092-uftc8inx 9951 5 ID ID NNP cord-010092-uftc8inx 9951 6 / / SYM cord-010092-uftc8inx 9951 7 IAT IAT NNP cord-010092-uftc8inx 9951 8 - - HYPH cord-010092-uftc8inx 9951 9 cards card NNS cord-010092-uftc8inx 9952 1 ( ( -LRB- cord-010092-uftc8inx 9952 2 Bio Bio NNP cord-010092-uftc8inx 9952 3 - - HYPH cord-010092-uftc8inx 9952 4 Rad Rad NNP cord-010092-uftc8inx 9952 5 ) ) -RRB- cord-010092-uftc8inx 9952 6 was be VBD cord-010092-uftc8inx 9952 7 done do VBN cord-010092-uftc8inx 9952 8 using use VBG cord-010092-uftc8inx 9952 9 commercial commercial JJ cord-010092-uftc8inx 9952 10 anti anti JJ cord-010092-uftc8inx 9952 11 - - JJ cord-010092-uftc8inx 9952 12 D d JJ cord-010092-uftc8inx 9952 13 antibodies antibody NNS cord-010092-uftc8inx 9952 14 . . . cord-010092-uftc8inx 9953 1 The the DT cord-010092-uftc8inx 9953 2 adsorption adsorption NN cord-010092-uftc8inx 9953 3 - - HYPH cord-010092-uftc8inx 9953 4 elution elution NN cord-010092-uftc8inx 9953 5 analysis analysis NN cord-010092-uftc8inx 9953 6 was be VBD cord-010092-uftc8inx 9953 7 performed perform VBN cord-010092-uftc8inx 9953 8 using use VBG cord-010092-uftc8inx 9953 9 an an DT cord-010092-uftc8inx 9953 10 in in IN cord-010092-uftc8inx 9953 11 - - HYPH cord-010092-uftc8inx 9953 12 house house NN cord-010092-uftc8inx 9953 13 pool pool NN cord-010092-uftc8inx 9953 14 of of IN cord-010092-uftc8inx 9953 15 polyclonal polyclonal JJ cord-010092-uftc8inx 9953 16 anti anti JJ cord-010092-uftc8inx 9953 17 - - JJ cord-010092-uftc8inx 9953 18 D d JJ cord-010092-uftc8inx 9953 19 antibodies antibody NNS cord-010092-uftc8inx 9953 20 . . . cord-010092-uftc8inx 9954 1 Furthermore furthermore RB cord-010092-uftc8inx 9954 2 an an DT cord-010092-uftc8inx 9954 3 antibody antibody NN cord-010092-uftc8inx 9954 4 D d NN cord-010092-uftc8inx 9954 5 - - HYPH cord-010092-uftc8inx 9954 6 screen screen NN cord-010092-uftc8inx 9954 7 was be VBD cord-010092-uftc8inx 9954 8 performed perform VBN cord-010092-uftc8inx 9954 9 ( ( -LRB- cord-010092-uftc8inx 9954 10 DIAGAST DIAGAST NNP cord-010092-uftc8inx 9954 11 ) ) -RRB- cord-010092-uftc8inx 9954 12 . . . cord-010092-uftc8inx 9955 1 For for IN cord-010092-uftc8inx 9955 2 RHD RHD NNP cord-010092-uftc8inx 9955 3 genotyping genotyping NN cord-010092-uftc8inx 9955 4 RH RH NNP cord-010092-uftc8inx 9955 5 - - HYPH cord-010092-uftc8inx 9955 6 TYPE TYPE NNP cord-010092-uftc8inx 9955 7 and and CC cord-010092-uftc8inx 9955 8 Partial Partial NNP cord-010092-uftc8inx 9955 9 D D NNP cord-010092-uftc8inx 9955 10 - - HYPH cord-010092-uftc8inx 9955 11 Type type NN cord-010092-uftc8inx 9955 12 assays assay NNS cord-010092-uftc8inx 9955 13 ( ( -LRB- cord-010092-uftc8inx 9955 14 BAG BAG NNP cord-010092-uftc8inx 9955 15 Health Health NNP cord-010092-uftc8inx 9955 16 Care Care NNP cord-010092-uftc8inx 9955 17 ) ) -RRB- cord-010092-uftc8inx 9955 18 were be VBD cord-010092-uftc8inx 9955 19 carried carry VBN cord-010092-uftc8inx 9955 20 out out RP cord-010092-uftc8inx 9955 21 . . . cord-010092-uftc8inx 9956 1 The the DT cord-010092-uftc8inx 9956 2 sample sample NN cord-010092-uftc8inx 9956 3 was be VBD cord-010092-uftc8inx 9956 4 further further RB cord-010092-uftc8inx 9956 5 characterized characterize VBN cord-010092-uftc8inx 9956 6 by by IN cord-010092-uftc8inx 9956 7 exon exon NN cord-010092-uftc8inx 9956 8 sequencing sequencing NN cord-010092-uftc8inx 9956 9 including include VBG cord-010092-uftc8inx 9956 10 flanking flank VBG cord-010092-uftc8inx 9956 11 intronic intronic JJ cord-010092-uftc8inx 9956 12 regions region NNS cord-010092-uftc8inx 9956 13 . . . cord-010092-uftc8inx 9957 1 RNA RNA NNP cord-010092-uftc8inx 9957 2 was be VBD cord-010092-uftc8inx 9957 3 extracted extract VBN cord-010092-uftc8inx 9957 4 from from IN cord-010092-uftc8inx 9957 5 whole whole JJ cord-010092-uftc8inx 9957 6 blood blood NN cord-010092-uftc8inx 9957 7 , , , cord-010092-uftc8inx 9957 8 reverse reverse VB cord-010092-uftc8inx 9957 9 transcribed transcribe VBN cord-010092-uftc8inx 9957 10 and and CC cord-010092-uftc8inx 9957 11 the the DT cord-010092-uftc8inx 9957 12 cDNA cdna NN cord-010092-uftc8inx 9957 13 sequenced sequence VBN cord-010092-uftc8inx 9957 14 . . . cord-010092-uftc8inx 9958 1 For for IN cord-010092-uftc8inx 9958 2 amplification amplification NN cord-010092-uftc8inx 9958 3 and and CC cord-010092-uftc8inx 9958 4 sequencing sequencing NN cord-010092-uftc8inx 9958 5 , , , cord-010092-uftc8inx 9958 6 both both DT cord-010092-uftc8inx 9958 7 published publish VBN cord-010092-uftc8inx 9958 8 ( ( -LRB- cord-010092-uftc8inx 9958 9 Gassner Gassner NNP cord-010092-uftc8inx 9958 10 , , , cord-010092-uftc8inx 9958 11 Transfusion Transfusion NNP cord-010092-uftc8inx 9958 12 , , , cord-010092-uftc8inx 9958 13 2005 2005 CD cord-010092-uftc8inx 9958 14 ; ; : cord-010092-uftc8inx 9958 15 Legler Legler NNP cord-010092-uftc8inx 9958 16 , , , cord-010092-uftc8inx 9958 17 Trans Trans NNP cord-010092-uftc8inx 9958 18 . . . cord-010092-uftc8inx 9959 1 Med Med NNP cord-010092-uftc8inx 9959 2 . . NNP cord-010092-uftc8inx 9959 3 , , , cord-010092-uftc8inx 9959 4 2001 2001 CD cord-010092-uftc8inx 9959 5 ; ; : cord-010092-uftc8inx 9959 6 Richard Richard NNP cord-010092-uftc8inx 9959 7 , , , cord-010092-uftc8inx 9959 8 Transfusion Transfusion NNP cord-010092-uftc8inx 9959 9 , , , cord-010092-uftc8inx 9959 10 2007 2007 CD cord-010092-uftc8inx 9959 11 ) ) -RRB- cord-010092-uftc8inx 9959 12 and and CC cord-010092-uftc8inx 9959 13 in in IN cord-010092-uftc8inx 9959 14 - - HYPH cord-010092-uftc8inx 9959 15 house house NN cord-010092-uftc8inx 9959 16 primers primer NNS cord-010092-uftc8inx 9959 17 were be VBD cord-010092-uftc8inx 9959 18 used use VBN cord-010092-uftc8inx 9959 19 . . . cord-010092-uftc8inx 9960 1 Results result NNS cord-010092-uftc8inx 9960 2 : : : cord-010092-uftc8inx 9961 1 Repeated repeat VBN cord-010092-uftc8inx 9961 2 phenotyping phenotyping NN cord-010092-uftc8inx 9961 3 of of IN cord-010092-uftc8inx 9961 4 the the DT cord-010092-uftc8inx 9961 5 sample sample NN cord-010092-uftc8inx 9961 6 with with IN cord-010092-uftc8inx 9961 7 commercial commercial NN cord-010092-uftc8inx 9961 8 as as RB cord-010092-uftc8inx 9961 9 well well RB cord-010092-uftc8inx 9961 10 as as IN cord-010092-uftc8inx 9961 11 , , , cord-010092-uftc8inx 9961 12 in in IN cord-010092-uftc8inx 9961 13 - - HYPH cord-010092-uftc8inx 9961 14 house house NN cord-010092-uftc8inx 9961 15 anti anti JJ cord-010092-uftc8inx 9961 16 - - JJ cord-010092-uftc8inx 9961 17 D d JJ cord-010092-uftc8inx 9961 18 antibodies antibody NNS cord-010092-uftc8inx 9961 19 confirmed confirm VBD cord-010092-uftc8inx 9961 20 the the DT cord-010092-uftc8inx 9961 21 RhD rhd NN cord-010092-uftc8inx 9961 22 negativity negativity NN cord-010092-uftc8inx 9961 23 . . . cord-010092-uftc8inx 9962 1 In in IN cord-010092-uftc8inx 9962 2 addition addition NN cord-010092-uftc8inx 9962 3 , , , cord-010092-uftc8inx 9962 4 the the DT cord-010092-uftc8inx 9962 5 adsorption adsorption NN cord-010092-uftc8inx 9962 6 - - HYPH cord-010092-uftc8inx 9962 7 elution elution NN cord-010092-uftc8inx 9962 8 analysis analysis NN cord-010092-uftc8inx 9962 9 showed show VBD cord-010092-uftc8inx 9962 10 a a DT cord-010092-uftc8inx 9962 11 negative negative JJ cord-010092-uftc8inx 9962 12 result result NN cord-010092-uftc8inx 9962 13 . . . cord-010092-uftc8inx 9963 1 However however RB cord-010092-uftc8inx 9963 2 , , , cord-010092-uftc8inx 9963 3 genotyping genotyping NN cord-010092-uftc8inx 9963 4 , , , cord-010092-uftc8inx 9963 5 using use VBG cord-010092-uftc8inx 9963 6 commercially commercially RB cord-010092-uftc8inx 9963 7 available available JJ cord-010092-uftc8inx 9963 8 kits kit NNS cord-010092-uftc8inx 9963 9 , , , cord-010092-uftc8inx 9963 10 yielded yield VBD cord-010092-uftc8inx 9963 11 a a DT cord-010092-uftc8inx 9963 12 RHD RHD NNP cord-010092-uftc8inx 9963 13 positive positive JJ cord-010092-uftc8inx 9963 14 result result NN cord-010092-uftc8inx 9963 15 and and CC cord-010092-uftc8inx 9963 16 no no DT cord-010092-uftc8inx 9963 17 variants variant NNS cord-010092-uftc8inx 9963 18 were be VBD cord-010092-uftc8inx 9963 19 detected detect VBN cord-010092-uftc8inx 9963 20 . . . cord-010092-uftc8inx 9964 1 To to TO cord-010092-uftc8inx 9964 2 investigate investigate VB cord-010092-uftc8inx 9964 3 this this DT cord-010092-uftc8inx 9964 4 discrepancy discrepancy NN cord-010092-uftc8inx 9964 5 , , , cord-010092-uftc8inx 9964 6 all all DT cord-010092-uftc8inx 9964 7 10 10 CD cord-010092-uftc8inx 9964 8 RHD RHD NNP cord-010092-uftc8inx 9964 9 exons exon NNS cord-010092-uftc8inx 9964 10 were be VBD cord-010092-uftc8inx 9964 11 sequenced sequence VBN cord-010092-uftc8inx 9964 12 . . . cord-010092-uftc8inx 9965 1 The the DT cord-010092-uftc8inx 9965 2 sequencing sequencing NN cord-010092-uftc8inx 9965 3 data datum NNS cord-010092-uftc8inx 9965 4 revealed reveal VBD cord-010092-uftc8inx 9965 5 the the DT cord-010092-uftc8inx 9965 6 mutation mutation NN cord-010092-uftc8inx 9965 7 c.148 c.148 NN cord-010092-uftc8inx 9965 8 + + SYM cord-010092-uftc8inx 9965 9 2delT 2delt CD cord-010092-uftc8inx 9965 10 in in IN cord-010092-uftc8inx 9965 11 the the DT cord-010092-uftc8inx 9965 12 splice splice NN cord-010092-uftc8inx 9965 13 donor donor NN cord-010092-uftc8inx 9965 14 site site NN cord-010092-uftc8inx 9965 15 of of IN cord-010092-uftc8inx 9965 16 exon exon NN cord-010092-uftc8inx 9965 17 1 1 CD cord-010092-uftc8inx 9965 18 . . . cord-010092-uftc8inx 9966 1 To to TO cord-010092-uftc8inx 9966 2 confirm confirm VB cord-010092-uftc8inx 9966 3 the the DT cord-010092-uftc8inx 9966 4 effect effect NN cord-010092-uftc8inx 9966 5 of of IN cord-010092-uftc8inx 9966 6 the the DT cord-010092-uftc8inx 9966 7 splice splice NN cord-010092-uftc8inx 9966 8 site site NN cord-010092-uftc8inx 9966 9 mutation mutation NN cord-010092-uftc8inx 9966 10 on on IN cord-010092-uftc8inx 9966 11 transcription transcription NN cord-010092-uftc8inx 9966 12 , , , cord-010092-uftc8inx 9966 13 RNA RNA NNP cord-010092-uftc8inx 9966 14 from from IN cord-010092-uftc8inx 9966 15 a a DT cord-010092-uftc8inx 9966 16 fresh fresh JJ cord-010092-uftc8inx 9966 17 whole whole JJ cord-010092-uftc8inx 9966 18 blood blood NN cord-010092-uftc8inx 9966 19 sample sample NN cord-010092-uftc8inx 9966 20 was be VBD cord-010092-uftc8inx 9966 21 analysed analyse VBN cord-010092-uftc8inx 9966 22 . . . cord-010092-uftc8inx 9967 1 As as IN cord-010092-uftc8inx 9967 2 a a DT cord-010092-uftc8inx 9967 3 positive positive JJ cord-010092-uftc8inx 9967 4 control control NN cord-010092-uftc8inx 9967 5 , , , cord-010092-uftc8inx 9967 6 GYPB GYPB NNP cord-010092-uftc8inx 9967 7 was be VBD cord-010092-uftc8inx 9967 8 amplified amplify VBN cord-010092-uftc8inx 9967 9 and and CC cord-010092-uftc8inx 9967 10 sequenced sequence VBN cord-010092-uftc8inx 9967 11 from from IN cord-010092-uftc8inx 9967 12 the the DT cord-010092-uftc8inx 9967 13 same same JJ cord-010092-uftc8inx 9967 14 cDNA cdna NN cord-010092-uftc8inx 9967 15 . . . cord-010092-uftc8inx 9967 16 Wild wild JJ cord-010092-uftc8inx 9967 17 - - HYPH cord-010092-uftc8inx 9967 18 type type NN cord-010092-uftc8inx 9967 19 GYPB GYPB NNP cord-010092-uftc8inx 9967 20 ( ( -LRB- cord-010092-uftc8inx 9967 21 MNS4 MNS4 NNP cord-010092-uftc8inx 9967 22 ) ) -RRB- cord-010092-uftc8inx 9967 23 was be VBD cord-010092-uftc8inx 9967 24 found find VBN cord-010092-uftc8inx 9967 25 . . . cord-010092-uftc8inx 9968 1 With with IN cord-010092-uftc8inx 9968 2 RHD RHD NNP cord-010092-uftc8inx 9968 3 specific specific JJ cord-010092-uftc8inx 9968 4 primers primer NNS cord-010092-uftc8inx 9968 5 , , , cord-010092-uftc8inx 9968 6 no no DT cord-010092-uftc8inx 9968 7 product product NN cord-010092-uftc8inx 9968 8 could could MD cord-010092-uftc8inx 9968 9 be be VB cord-010092-uftc8inx 9968 10 amplified amplify VBN cord-010092-uftc8inx 9968 11 . . . cord-010092-uftc8inx 9969 1 Summary Summary NNP cord-010092-uftc8inx 9969 2 / / SYM cord-010092-uftc8inx 9969 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 9969 4 : : : cord-010092-uftc8inx 9970 1 We -PRON- PRP cord-010092-uftc8inx 9970 2 present present VBP cord-010092-uftc8inx 9970 3 a a DT cord-010092-uftc8inx 9970 4 serologically serologically RB cord-010092-uftc8inx 9970 5 RhD rhd NN cord-010092-uftc8inx 9970 6 negative negative JJ cord-010092-uftc8inx 9970 7 case case NN cord-010092-uftc8inx 9970 8 , , , cord-010092-uftc8inx 9970 9 that that WDT cord-010092-uftc8inx 9970 10 was be VBD cord-010092-uftc8inx 9970 11 identified identify VBN cord-010092-uftc8inx 9970 12 as as IN cord-010092-uftc8inx 9970 13 RHD RHD NNP cord-010092-uftc8inx 9970 14 positive positive JJ cord-010092-uftc8inx 9970 15 by by IN cord-010092-uftc8inx 9970 16 standard standard JJ cord-010092-uftc8inx 9970 17 commercial commercial JJ cord-010092-uftc8inx 9970 18 genotyping genotyping NN cord-010092-uftc8inx 9970 19 kits kit NNS cord-010092-uftc8inx 9970 20 . . . cord-010092-uftc8inx 9971 1 Sequencing sequencing NN cord-010092-uftc8inx 9971 2 revealed reveal VBD cord-010092-uftc8inx 9971 3 the the DT cord-010092-uftc8inx 9971 4 new new JJ cord-010092-uftc8inx 9971 5 splice splice NN cord-010092-uftc8inx 9971 6 site site NN cord-010092-uftc8inx 9971 7 mutation mutation NN cord-010092-uftc8inx 9971 8 c.148 c.148 NN cord-010092-uftc8inx 9971 9 + + CC cord-010092-uftc8inx 9971 10 2delT. 2delt. CD cord-010092-uftc8inx 9971 11 RNA RNA NNP cord-010092-uftc8inx 9971 12 sequencing sequencing NN cord-010092-uftc8inx 9971 13 yielded yield VBD cord-010092-uftc8inx 9971 14 no no DT cord-010092-uftc8inx 9971 15 detectable detectable JJ cord-010092-uftc8inx 9971 16 product product NN cord-010092-uftc8inx 9971 17 . . . cord-010092-uftc8inx 9972 1 The the DT cord-010092-uftc8inx 9972 2 donor donor NN cord-010092-uftc8inx 9972 3 was be VBD cord-010092-uftc8inx 9972 4 classified classify VBN cord-010092-uftc8inx 9972 5 as as IN cord-010092-uftc8inx 9972 6 RhD RhD NNP cord-010092-uftc8inx 9972 7 negative negative JJ cord-010092-uftc8inx 9972 8 . . . cord-010092-uftc8inx 9973 1 This this DT cord-010092-uftc8inx 9973 2 case case NN cord-010092-uftc8inx 9973 3 of of IN cord-010092-uftc8inx 9973 4 a a DT cord-010092-uftc8inx 9973 5 discrepant discrepant JJ cord-010092-uftc8inx 9973 6 result result NN cord-010092-uftc8inx 9973 7 between between IN cord-010092-uftc8inx 9973 8 serology serology NN cord-010092-uftc8inx 9973 9 and and CC cord-010092-uftc8inx 9973 10 genetics genetics NN cord-010092-uftc8inx 9973 11 shows show VBZ cord-010092-uftc8inx 9973 12 the the DT cord-010092-uftc8inx 9973 13 importance importance NN cord-010092-uftc8inx 9973 14 of of IN cord-010092-uftc8inx 9973 15 a a DT cord-010092-uftc8inx 9973 16 profound profound JJ cord-010092-uftc8inx 9973 17 and and CC cord-010092-uftc8inx 9973 18 highly highly RB cord-010092-uftc8inx 9973 19 sophisticated sophisticated JJ cord-010092-uftc8inx 9973 20 genetic genetic JJ cord-010092-uftc8inx 9973 21 investigation investigation NN cord-010092-uftc8inx 9973 22 of of IN cord-010092-uftc8inx 9973 23 conflicting conflict VBG cord-010092-uftc8inx 9973 24 laboratory laboratory NN cord-010092-uftc8inx 9973 25 results result NNS cord-010092-uftc8inx 9973 26 . . . cord-010092-uftc8inx 9974 1 J J NNP cord-010092-uftc8inx 9974 2 Stettler Stettler NNP cord-010092-uftc8inx 9974 3 , , , cord-010092-uftc8inx 9974 4 S S NNP cord-010092-uftc8inx 9974 5 Lejon Lejon NNP cord-010092-uftc8inx 9974 6 Crottet Crottet NNP cord-010092-uftc8inx 9974 7 , , , cord-010092-uftc8inx 9974 8 H H NNP cord-010092-uftc8inx 9974 9 Hustinx Hustinx NNP cord-010092-uftc8inx 9974 10 , , , cord-010092-uftc8inx 9974 11 C C NNP cord-010092-uftc8inx 9974 12 von von NNP cord-010092-uftc8inx 9974 13 Arx Arx NNP cord-010092-uftc8inx 9974 14 , , , cord-010092-uftc8inx 9974 15 F F NNP cord-010092-uftc8inx 9974 16 Still Still NNP cord-010092-uftc8inx 9974 17 , , , cord-010092-uftc8inx 9974 18 J J NNP cord-010092-uftc8inx 9974 19 Graber Graber NNP cord-010092-uftc8inx 9974 20 , , , cord-010092-uftc8inx 9974 21 C C NNP cord-010092-uftc8inx 9974 22 Niederhauser Niederhauser NNP cord-010092-uftc8inx 9974 23 and and CC cord-010092-uftc8inx 9974 24 C C NNP cord-010092-uftc8inx 9974 25 Henny Henny NNP cord-010092-uftc8inx 9974 26 Interregional Interregional NNP cord-010092-uftc8inx 9974 27 Blood Blood NNP cord-010092-uftc8inx 9974 28 Transfusion Transfusion NNP cord-010092-uftc8inx 9974 29 SRC SRC NNP cord-010092-uftc8inx 9974 30 Berne Berne NNP cord-010092-uftc8inx 9974 31 Ltd. Ltd. NNP cord-010092-uftc8inx 9974 32 , , , cord-010092-uftc8inx 9974 33 Berne Berne NNP cord-010092-uftc8inx 9974 34 , , , cord-010092-uftc8inx 9974 35 Switzerland Switzerland NNP cord-010092-uftc8inx 9974 36 Background Background NNP cord-010092-uftc8inx 9974 37 : : : cord-010092-uftc8inx 9974 38 One one CD cord-010092-uftc8inx 9974 39 of of IN cord-010092-uftc8inx 9974 40 the the DT cord-010092-uftc8inx 9974 41 most most RBS cord-010092-uftc8inx 9974 42 immunogenic immunogenic JJ cord-010092-uftc8inx 9974 43 and and CC cord-010092-uftc8inx 9974 44 clinically clinically RB cord-010092-uftc8inx 9974 45 significant significant JJ cord-010092-uftc8inx 9974 46 blood blood NN cord-010092-uftc8inx 9974 47 group group NN cord-010092-uftc8inx 9974 48 antigens antigen NNS cord-010092-uftc8inx 9974 49 in in IN cord-010092-uftc8inx 9974 50 transfusion transfusion NN cord-010092-uftc8inx 9974 51 medicine medicine NN cord-010092-uftc8inx 9974 52 is be VBZ cord-010092-uftc8inx 9974 53 the the DT cord-010092-uftc8inx 9974 54 RhD RhD NNP cord-010092-uftc8inx 9974 55 antigen antigen NNP cord-010092-uftc8inx 9974 56 . . . cord-010092-uftc8inx 9975 1 Variant variant JJ cord-010092-uftc8inx 9975 2 RhD rhd NN cord-010092-uftc8inx 9975 3 phenotypes phenotype NNS cord-010092-uftc8inx 9975 4 with with IN cord-010092-uftc8inx 9975 5 weakened weakened JJ cord-010092-uftc8inx 9975 6 or or CC cord-010092-uftc8inx 9975 7 absent absent JJ cord-010092-uftc8inx 9975 8 antigen antigen NN cord-010092-uftc8inx 9975 9 expression expression NN cord-010092-uftc8inx 9975 10 pose pose VBP cord-010092-uftc8inx 9975 11 a a DT cord-010092-uftc8inx 9975 12 challenge challenge NN cord-010092-uftc8inx 9975 13 for for IN cord-010092-uftc8inx 9975 14 RhD rhd NN cord-010092-uftc8inx 9975 15 status status NN cord-010092-uftc8inx 9975 16 assignment assignment NN cord-010092-uftc8inx 9975 17 in in IN cord-010092-uftc8inx 9975 18 blood blood NN cord-010092-uftc8inx 9975 19 donors donor NNS cord-010092-uftc8inx 9975 20 . . . cord-010092-uftc8inx 9976 1 To to TO cord-010092-uftc8inx 9976 2 ensure ensure VB cord-010092-uftc8inx 9976 3 patient patient JJ cord-010092-uftc8inx 9976 4 safety safety NN cord-010092-uftc8inx 9976 5 , , , cord-010092-uftc8inx 9976 6 it -PRON- PRP cord-010092-uftc8inx 9976 7 is be VBZ cord-010092-uftc8inx 9976 8 necessary necessary JJ cord-010092-uftc8inx 9976 9 to to TO cord-010092-uftc8inx 9976 10 fully fully RB cord-010092-uftc8inx 9976 11 characterize characterize VB cord-010092-uftc8inx 9976 12 these these DT cord-010092-uftc8inx 9976 13 variants variant NNS cord-010092-uftc8inx 9976 14 at at IN cord-010092-uftc8inx 9976 15 the the DT cord-010092-uftc8inx 9976 16 molecular molecular JJ cord-010092-uftc8inx 9976 17 level level NN cord-010092-uftc8inx 9976 18 . . . cord-010092-uftc8inx 9977 1 Aims aim NNS cord-010092-uftc8inx 9977 2 : : : cord-010092-uftc8inx 9977 3 Samples sample NNS cord-010092-uftc8inx 9977 4 from from IN cord-010092-uftc8inx 9977 5 two two CD cord-010092-uftc8inx 9977 6 donors donor NNS cord-010092-uftc8inx 9977 7 were be VBD cord-010092-uftc8inx 9977 8 investigated investigate VBN cord-010092-uftc8inx 9977 9 in in IN cord-010092-uftc8inx 9977 10 our -PRON- PRP$ cord-010092-uftc8inx 9977 11 laboratory laboratory NN cord-010092-uftc8inx 9977 12 due due IN cord-010092-uftc8inx 9977 13 to to IN cord-010092-uftc8inx 9977 14 discrepancy discrepancy NN cord-010092-uftc8inx 9977 15 in in IN cord-010092-uftc8inx 9977 16 RhD rhd NN cord-010092-uftc8inx 9977 17 typing typing NN cord-010092-uftc8inx 9977 18 . . . cord-010092-uftc8inx 9978 1 Methods method NNS cord-010092-uftc8inx 9978 2 : : : cord-010092-uftc8inx 9978 3 Rh Rh NNP cord-010092-uftc8inx 9978 4 blood blood NN cord-010092-uftc8inx 9978 5 group group NN cord-010092-uftc8inx 9978 6 phenotyping phenotyping NN cord-010092-uftc8inx 9978 7 was be VBD cord-010092-uftc8inx 9978 8 done do VBN cord-010092-uftc8inx 9978 9 by by IN cord-010092-uftc8inx 9978 10 standard standard JJ cord-010092-uftc8inx 9978 11 serological serological JJ cord-010092-uftc8inx 9978 12 column column NN cord-010092-uftc8inx 9978 13 agglutination agglutination NN cord-010092-uftc8inx 9978 14 testing testing NN cord-010092-uftc8inx 9978 15 ( ( -LRB- cord-010092-uftc8inx 9978 16 ID id NN cord-010092-uftc8inx 9978 17 - - HYPH cord-010092-uftc8inx 9978 18 system system NN cord-010092-uftc8inx 9978 19 , , , cord-010092-uftc8inx 9978 20 BioRad BioRad NNP cord-010092-uftc8inx 9978 21 ) ) -RRB- cord-010092-uftc8inx 9978 22 . . . cord-010092-uftc8inx 9979 1 Further further JJ cord-010092-uftc8inx 9979 2 RhD rhd NN cord-010092-uftc8inx 9979 3 characterization characterization NN cord-010092-uftc8inx 9979 4 was be VBD cord-010092-uftc8inx 9979 5 performed perform VBN cord-010092-uftc8inx 9979 6 by by IN cord-010092-uftc8inx 9979 7 an an DT cord-010092-uftc8inx 9979 8 anti anti JJ cord-010092-uftc8inx 9979 9 - - JJ cord-010092-uftc8inx 9979 10 D d JJ cord-010092-uftc8inx 9979 11 antibody antibody NN cord-010092-uftc8inx 9979 12 panel panel NN cord-010092-uftc8inx 9979 13 containing contain VBG cord-010092-uftc8inx 9979 14 9 9 CD cord-010092-uftc8inx 9979 15 monoclonal monoclonal JJ cord-010092-uftc8inx 9979 16 antibodies antibody NNS cord-010092-uftc8inx 9979 17 ( ( -LRB- cord-010092-uftc8inx 9979 18 D D NNP cord-010092-uftc8inx 9979 19 - - HYPH cord-010092-uftc8inx 9979 20 Screen screen NN cord-010092-uftc8inx 9979 21 , , , cord-010092-uftc8inx 9979 22 Diagast Diagast NNP cord-010092-uftc8inx 9979 23 ) ) -RRB- cord-010092-uftc8inx 9979 24 and and CC cord-010092-uftc8inx 9979 25 an an DT cord-010092-uftc8inx 9979 26 adsorption adsorption NN cord-010092-uftc8inx 9979 27 - - HYPH cord-010092-uftc8inx 9979 28 elution elution NN cord-010092-uftc8inx 9979 29 test test NN cord-010092-uftc8inx 9979 30 using use VBG cord-010092-uftc8inx 9979 31 an an DT cord-010092-uftc8inx 9979 32 in in IN cord-010092-uftc8inx 9979 33 - - HYPH cord-010092-uftc8inx 9979 34 house house NN cord-010092-uftc8inx 9979 35 pool pool NN cord-010092-uftc8inx 9979 36 of of IN cord-010092-uftc8inx 9979 37 polyclonal polyclonal JJ cord-010092-uftc8inx 9979 38 anti anti JJ cord-010092-uftc8inx 9979 39 - - JJ cord-010092-uftc8inx 9979 40 D d JJ cord-010092-uftc8inx 9979 41 antibodies antibody NNS cord-010092-uftc8inx 9979 42 . . . cord-010092-uftc8inx 9980 1 Molecular molecular JJ cord-010092-uftc8inx 9980 2 investigation investigation NN cord-010092-uftc8inx 9980 3 was be VBD cord-010092-uftc8inx 9980 4 initially initially RB cord-010092-uftc8inx 9980 5 performed perform VBN cord-010092-uftc8inx 9980 6 by by IN cord-010092-uftc8inx 9980 7 SSP SSP NNP cord-010092-uftc8inx 9980 8 - - HYPH cord-010092-uftc8inx 9980 9 PCR PCR NNP cord-010092-uftc8inx 9980 10 detecting detect VBG cord-010092-uftc8inx 9980 11 common common JJ cord-010092-uftc8inx 9980 12 RHD RHD NNP cord-010092-uftc8inx 9980 13 variants variant NNS cord-010092-uftc8inx 9980 14 ( ( -LRB- cord-010092-uftc8inx 9980 15 RBC RBC NNP cord-010092-uftc8inx 9980 16 - - HYPH cord-010092-uftc8inx 9980 17 Ready Ready NNP cord-010092-uftc8inx 9980 18 Gene Gene NNP cord-010092-uftc8inx 9980 19 CDE CDE NNP cord-010092-uftc8inx 9980 20 Inno Inno NNP cord-010092-uftc8inx 9980 21 - - HYPH cord-010092-uftc8inx 9980 22 Train Train NNP cord-010092-uftc8inx 9980 23 ; ; : cord-010092-uftc8inx 9980 24 RH rh NN cord-010092-uftc8inx 9980 25 - - HYPH cord-010092-uftc8inx 9980 26 TYPE TYPE NNP cord-010092-uftc8inx 9980 27 BAG BAG NNP cord-010092-uftc8inx 9980 28 Health Health NNP cord-010092-uftc8inx 9980 29 Care Care NNP cord-010092-uftc8inx 9980 30 ) ) -RRB- cord-010092-uftc8inx 9980 31 . . . cord-010092-uftc8inx 9981 1 RHD RHD NNP cord-010092-uftc8inx 9981 2 sequencing sequencing NN cord-010092-uftc8inx 9981 3 was be VBD cord-010092-uftc8inx 9981 4 done do VBN cord-010092-uftc8inx 9981 5 on on IN cord-010092-uftc8inx 9981 6 either either CC cord-010092-uftc8inx 9981 7 DNA DNA NNP cord-010092-uftc8inx 9981 8 or or CC cord-010092-uftc8inx 9981 9 RNA RNA NNP cord-010092-uftc8inx 9981 10 using use VBG cord-010092-uftc8inx 9981 11 published publish VBN cord-010092-uftc8inx 9981 12 and and CC cord-010092-uftc8inx 9981 13 inhouse inhouse NN cord-010092-uftc8inx 9981 14 primers primer NNS cord-010092-uftc8inx 9981 15 for for IN cord-010092-uftc8inx 9981 16 amplification amplification NN cord-010092-uftc8inx 9981 17 and and CC cord-010092-uftc8inx 9981 18 sequencing sequencing NN cord-010092-uftc8inx 9981 19 . . . cord-010092-uftc8inx 9982 1 Results result NNS cord-010092-uftc8inx 9982 2 : : : cord-010092-uftc8inx 9983 1 By by IN cord-010092-uftc8inx 9983 2 tube tube NN cord-010092-uftc8inx 9983 3 testing testing NN cord-010092-uftc8inx 9983 4 , , , cord-010092-uftc8inx 9983 5 the the DT cord-010092-uftc8inx 9983 6 RBCs rbc NNS cord-010092-uftc8inx 9983 7 of of IN cord-010092-uftc8inx 9983 8 Donor donor NN cord-010092-uftc8inx 9983 9 1 1 CD cord-010092-uftc8inx 9983 10 were be VBD cord-010092-uftc8inx 9983 11 predicted predict VBN cord-010092-uftc8inx 9983 12 to to TO cord-010092-uftc8inx 9983 13 be be VB cord-010092-uftc8inx 9983 14 RH:-1,-2,-3,4,5 RH:-1,-2,-3,4,5 NNP cord-010092-uftc8inx 9983 15 . . . cord-010092-uftc8inx 9984 1 However however RB cord-010092-uftc8inx 9984 2 , , , cord-010092-uftc8inx 9984 3 all all DT cord-010092-uftc8inx 9984 4 ten ten CD cord-010092-uftc8inx 9984 5 exons exon NNS cord-010092-uftc8inx 9984 6 of of IN cord-010092-uftc8inx 9984 7 the the DT cord-010092-uftc8inx 9984 8 RHD RHD NNP cord-010092-uftc8inx 9984 9 gene gene NN cord-010092-uftc8inx 9984 10 could could MD cord-010092-uftc8inx 9984 11 be be VB cord-010092-uftc8inx 9984 12 detected detect VBN cord-010092-uftc8inx 9984 13 by by IN cord-010092-uftc8inx 9984 14 routine routine JJ cord-010092-uftc8inx 9984 15 genotyping genotyping NN cord-010092-uftc8inx 9984 16 . . . cord-010092-uftc8inx 9985 1 Sequencing Sequencing NNP cord-010092-uftc8inx 9985 2 of of IN cord-010092-uftc8inx 9985 3 RHD RHD NNP cord-010092-uftc8inx 9985 4 revealed reveal VBD cord-010092-uftc8inx 9985 5 a a DT cord-010092-uftc8inx 9985 6 homozygous homozygous JJ cord-010092-uftc8inx 9985 7 mutation mutation NN cord-010092-uftc8inx 9985 8 C c NN cord-010092-uftc8inx 9986 1 > > XX cord-010092-uftc8inx 9987 1 G g NN cord-010092-uftc8inx 9987 2 at at IN cord-010092-uftc8inx 9987 3 position position NN cord-010092-uftc8inx 9987 4 1151 1151 CD cord-010092-uftc8inx 9987 5 which which WDT cord-010092-uftc8inx 9987 6 is be VBZ cord-010092-uftc8inx 9987 7 the the DT cord-010092-uftc8inx 9987 8 second second JJ cord-010092-uftc8inx 9987 9 last last JJ cord-010092-uftc8inx 9987 10 nucleotide nucleotide NN cord-010092-uftc8inx 9987 11 of of IN cord-010092-uftc8inx 9987 12 exon exon NN cord-010092-uftc8inx 9987 13 8 8 CD cord-010092-uftc8inx 9987 14 and and CC cord-010092-uftc8inx 9987 15 thus thus RB cord-010092-uftc8inx 9987 16 might may MD cord-010092-uftc8inx 9987 17 have have VB cord-010092-uftc8inx 9987 18 an an DT cord-010092-uftc8inx 9987 19 influence influence NN cord-010092-uftc8inx 9987 20 on on IN cord-010092-uftc8inx 9987 21 exon exon NN cord-010092-uftc8inx 9987 22 splicing splicing NN cord-010092-uftc8inx 9987 23 . . . cord-010092-uftc8inx 9988 1 By by IN cord-010092-uftc8inx 9988 2 cDNA cdna NN cord-010092-uftc8inx 9988 3 analysis analysis NN cord-010092-uftc8inx 9988 4 a a DT cord-010092-uftc8inx 9988 5 transcript transcript NN cord-010092-uftc8inx 9988 6 with with IN cord-010092-uftc8inx 9988 7 a a DT cord-010092-uftc8inx 9988 8 correctly correctly RB cord-010092-uftc8inx 9988 9 spliced splice VBN cord-010092-uftc8inx 9988 10 exon exon NN cord-010092-uftc8inx 9988 11 8 8 CD cord-010092-uftc8inx 9988 12 was be VBD cord-010092-uftc8inx 9988 13 identified identify VBN cord-010092-uftc8inx 9988 14 . . . cord-010092-uftc8inx 9989 1 The the DT cord-010092-uftc8inx 9989 2 mutation mutation NN cord-010092-uftc8inx 9989 3 c.1151C c.1151c XX cord-010092-uftc8inx 9989 4 > > XX cord-010092-uftc8inx 9990 1 G g NN cord-010092-uftc8inx 9990 2 leads lead VBZ cord-010092-uftc8inx 9990 3 to to IN cord-010092-uftc8inx 9990 4 the the DT cord-010092-uftc8inx 9990 5 amino amino NN cord-010092-uftc8inx 9990 6 acid acid NN cord-010092-uftc8inx 9990 7 substitution substitution NN cord-010092-uftc8inx 9990 8 T384R T384R NNS cord-010092-uftc8inx 9990 9 located locate VBN cord-010092-uftc8inx 9990 10 in in IN cord-010092-uftc8inx 9990 11 the the DT cord-010092-uftc8inx 9990 12 twelfth twelfth JJ cord-010092-uftc8inx 9990 13 transmembrane transmembrane NN cord-010092-uftc8inx 9990 14 domain domain NN cord-010092-uftc8inx 9990 15 of of IN cord-010092-uftc8inx 9990 16 RhD rhd NN cord-010092-uftc8inx 9990 17 using use VBG cord-010092-uftc8inx 9990 18 the the DT cord-010092-uftc8inx 9990 19 model model NN cord-010092-uftc8inx 9990 20 of of IN cord-010092-uftc8inx 9990 21 Flegel Flegel NNP cord-010092-uftc8inx 9990 22 ( ( -LRB- cord-010092-uftc8inx 9990 23 Transfus Transfus NNP cord-010092-uftc8inx 9990 24 Apher Apher NNP cord-010092-uftc8inx 9990 25 Sci Sci NNP cord-010092-uftc8inx 9990 26 . . NNP cord-010092-uftc8inx 9990 27 , , , cord-010092-uftc8inx 9990 28 2011 2011 CD cord-010092-uftc8inx 9990 29 ) ) -RRB- cord-010092-uftc8inx 9990 30 as as IN cord-010092-uftc8inx 9990 31 reference reference NN cord-010092-uftc8inx 9990 32 . . . cord-010092-uftc8inx 9991 1 Adsorption adsorption NN cord-010092-uftc8inx 9991 2 - - HYPH cord-010092-uftc8inx 9991 3 elution elution NN cord-010092-uftc8inx 9991 4 testing testing NN cord-010092-uftc8inx 9991 5 using use VBG cord-010092-uftc8inx 9991 6 a a DT cord-010092-uftc8inx 9991 7 pool pool NN cord-010092-uftc8inx 9991 8 of of IN cord-010092-uftc8inx 9991 9 polyclonal polyclonal JJ cord-010092-uftc8inx 9991 10 anti anti JJ cord-010092-uftc8inx 9991 11 - - NNP cord-010092-uftc8inx 9991 12 D D NNP cord-010092-uftc8inx 9991 13 showed show VBD cord-010092-uftc8inx 9991 14 a a DT cord-010092-uftc8inx 9991 15 weak weak JJ cord-010092-uftc8inx 9991 16 positive positive JJ cord-010092-uftc8inx 9991 17 reaction reaction NN cord-010092-uftc8inx 9991 18 , , , cord-010092-uftc8inx 9991 19 re re VBN cord-010092-uftc8inx 9991 20 - - VBG cord-010092-uftc8inx 9991 21 classifying classify VBG cord-010092-uftc8inx 9991 22 the the DT cord-010092-uftc8inx 9991 23 donor donor NN cord-010092-uftc8inx 9991 24 as as IN cord-010092-uftc8inx 9991 25 RhD RhD NNP cord-010092-uftc8inx 9991 26 positive positive JJ cord-010092-uftc8inx 9991 27 . . . cord-010092-uftc8inx 9992 1 This this DT cord-010092-uftc8inx 9992 2 novel novel NN cord-010092-uftc8inx 9992 3 allele allele NN cord-010092-uftc8inx 9992 4 , , , cord-010092-uftc8inx 9992 5 RHD*1151 RHD*1151 NNP cord-010092-uftc8inx 9992 6 G G NNP cord-010092-uftc8inx 9992 7 , , , cord-010092-uftc8inx 9992 8 could could MD cord-010092-uftc8inx 9992 9 thus thus RB cord-010092-uftc8inx 9992 10 be be VB cord-010092-uftc8inx 9992 11 categorized categorize VBN cord-010092-uftc8inx 9992 12 as as IN cord-010092-uftc8inx 9992 13 a a DT cord-010092-uftc8inx 9992 14 DEL DEL NNP cord-010092-uftc8inx 9992 15 allele allele NN cord-010092-uftc8inx 9992 16 . . . cord-010092-uftc8inx 9993 1 Serological serological JJ cord-010092-uftc8inx 9993 2 results result NNS cord-010092-uftc8inx 9993 3 displayed display VBD cord-010092-uftc8inx 9993 4 an an DT cord-010092-uftc8inx 9993 5 almost almost RB cord-010092-uftc8inx 9993 6 normal normal JJ cord-010092-uftc8inx 9993 7 RhD rhd NN cord-010092-uftc8inx 9993 8 antigen antigen NN cord-010092-uftc8inx 9993 9 expression expression NN cord-010092-uftc8inx 9993 10 for for IN cord-010092-uftc8inx 9993 11 Donor donor NN cord-010092-uftc8inx 9993 12 2 2 CD cord-010092-uftc8inx 9993 13 . . . cord-010092-uftc8inx 9994 1 Further further JJ cord-010092-uftc8inx 9994 2 serological serological JJ cord-010092-uftc8inx 9994 3 determination determination NN cord-010092-uftc8inx 9994 4 of of IN cord-010092-uftc8inx 9994 5 the the DT cord-010092-uftc8inx 9994 6 RhD RhD NNP cord-010092-uftc8inx 9994 7 antigen antigen NNP cord-010092-uftc8inx 9994 8 with with IN cord-010092-uftc8inx 9994 9 9 9 CD cord-010092-uftc8inx 9994 10 different different JJ cord-010092-uftc8inx 9994 11 antisera antisera NN cord-010092-uftc8inx 9994 12 , , , cord-010092-uftc8inx 9994 13 however however RB cord-010092-uftc8inx 9994 14 , , , cord-010092-uftc8inx 9994 15 showed show VBD cord-010092-uftc8inx 9994 16 a a DT cord-010092-uftc8inx 9994 17 reaction reaction NN cord-010092-uftc8inx 9994 18 pattern pattern NN cord-010092-uftc8inx 9994 19 typically typically RB cord-010092-uftc8inx 9994 20 observed observe VBD cord-010092-uftc8inx 9994 21 with with IN cord-010092-uftc8inx 9994 22 a a DT cord-010092-uftc8inx 9994 23 weak weak JJ cord-010092-uftc8inx 9994 24 D d NN cord-010092-uftc8inx 9994 25 variant variant NN cord-010092-uftc8inx 9994 26 . . . cord-010092-uftc8inx 9995 1 With with IN cord-010092-uftc8inx 9995 2 commercial commercial JJ cord-010092-uftc8inx 9995 3 available available JJ cord-010092-uftc8inx 9995 4 kits kit NNS cord-010092-uftc8inx 9995 5 no no DT cord-010092-uftc8inx 9995 6 RHD RHD NNP cord-010092-uftc8inx 9995 7 variant variant NN cord-010092-uftc8inx 9995 8 could could MD cord-010092-uftc8inx 9995 9 be be VB cord-010092-uftc8inx 9995 10 detected detect VBN cord-010092-uftc8inx 9995 11 . . . cord-010092-uftc8inx 9996 1 RHD RHD NNP cord-010092-uftc8inx 9996 2 sequencing sequencing NN cord-010092-uftc8inx 9996 3 revealed reveal VBD cord-010092-uftc8inx 9996 4 a a DT cord-010092-uftc8inx 9996 5 novel novel JJ cord-010092-uftc8inx 9996 6 homozygous homozygous JJ cord-010092-uftc8inx 9996 7 mutation mutation NN cord-010092-uftc8inx 9996 8 c.526 c.526 NN cord-010092-uftc8inx 9996 9 G g NN cord-010092-uftc8inx 9996 10 > > XX cord-010092-uftc8inx 9997 1 C C NNP cord-010092-uftc8inx 9997 2 in in IN cord-010092-uftc8inx 9997 3 exon exon NN cord-010092-uftc8inx 9997 4 4 4 CD cord-010092-uftc8inx 9997 5 . . . cord-010092-uftc8inx 9998 1 This this DT cord-010092-uftc8inx 9998 2 mutation mutation NN cord-010092-uftc8inx 9998 3 causes cause VBZ cord-010092-uftc8inx 9998 4 a a DT cord-010092-uftc8inx 9998 5 p. p. NN cord-010092-uftc8inx 9999 1 A176P A176P NNP cord-010092-uftc8inx 9999 2 exchange exchange NN cord-010092-uftc8inx 9999 3 in in IN cord-010092-uftc8inx 9999 4 the the DT cord-010092-uftc8inx 9999 5 sixth sixth JJ cord-010092-uftc8inx 9999 6 membrane membrane NN cord-010092-uftc8inx 9999 7 - - HYPH cord-010092-uftc8inx 9999 8 spanning span VBG cord-010092-uftc8inx 9999 9 domain domain NN cord-010092-uftc8inx 9999 10 of of IN cord-010092-uftc8inx 9999 11 RhD. RhD. NNP cord-010092-uftc8inx 9999 12 Based Based NNP cord-010092-uftc8inx 9999 13 on on IN cord-010092-uftc8inx 9999 14 serological serological JJ cord-010092-uftc8inx 9999 15 data datum NNS cord-010092-uftc8inx 9999 16 , , , cord-010092-uftc8inx 9999 17 the the DT cord-010092-uftc8inx 9999 18 donor donor NN cord-010092-uftc8inx 9999 19 is be VBZ cord-010092-uftc8inx 9999 20 RhD rhd NN cord-010092-uftc8inx 9999 21 positive positive JJ cord-010092-uftc8inx 9999 22 and and CC cord-010092-uftc8inx 9999 23 in in IN cord-010092-uftc8inx 9999 24 case case NN cord-010092-uftc8inx 9999 25 of of IN cord-010092-uftc8inx 9999 26 transfusion transfusion NN cord-010092-uftc8inx 9999 27 the the DT cord-010092-uftc8inx 9999 28 patient patient NN cord-010092-uftc8inx 9999 29 would would MD cord-010092-uftc8inx 9999 30 be be VB cord-010092-uftc8inx 9999 31 treated treat VBN cord-010092-uftc8inx 9999 32 as as IN cord-010092-uftc8inx 9999 33 RhD rhd NN cord-010092-uftc8inx 9999 34 negative negative JJ cord-010092-uftc8inx 9999 35 . . . cord-010092-uftc8inx 10000 1 Summary Summary NNP cord-010092-uftc8inx 10000 2 / / SYM cord-010092-uftc8inx 10000 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 10000 4 : : : cord-010092-uftc8inx 10001 1 Here here RB cord-010092-uftc8inx 10001 2 we -PRON- PRP cord-010092-uftc8inx 10001 3 report report VBP cord-010092-uftc8inx 10001 4 two two CD cord-010092-uftc8inx 10001 5 novel novel JJ cord-010092-uftc8inx 10001 6 RHD RHD NNP cord-010092-uftc8inx 10001 7 missense missense NN cord-010092-uftc8inx 10001 8 mutations mutation NNS cord-010092-uftc8inx 10001 9 c.1151C c.1151C NNS cord-010092-uftc8inx 10002 1 > > XX cord-010092-uftc8inx 10003 1 G g NN cord-010092-uftc8inx 10003 2 and and CC cord-010092-uftc8inx 10003 3 c.526 c.526 NN cord-010092-uftc8inx 10003 4 G g NN cord-010092-uftc8inx 10003 5 > > XX cord-010092-uftc8inx 10004 1 C C NNP cord-010092-uftc8inx 10004 2 harbouring harbour VBG cord-010092-uftc8inx 10004 3 an an DT cord-010092-uftc8inx 10004 4 amino amino NN cord-010092-uftc8inx 10004 5 acid acid NN cord-010092-uftc8inx 10004 6 substitution substitution NN cord-010092-uftc8inx 10004 7 within within IN cord-010092-uftc8inx 10004 8 a a DT cord-010092-uftc8inx 10004 9 transmembrane transmembrane NN cord-010092-uftc8inx 10004 10 segment segment NN cord-010092-uftc8inx 10004 11 . . . cord-010092-uftc8inx 10005 1 The the DT cord-010092-uftc8inx 10006 1 c.1151C c.1151C NNS cord-010092-uftc8inx 10006 2 > > XX cord-010092-uftc8inx 10006 3 G g NN cord-010092-uftc8inx 10006 4 variation variation NN cord-010092-uftc8inx 10006 5 displayed display VBD cord-010092-uftc8inx 10006 6 an an DT cord-010092-uftc8inx 10006 7 unusual unusual JJ cord-010092-uftc8inx 10006 8 low low JJ cord-010092-uftc8inx 10006 9 RhD rhd NN cord-010092-uftc8inx 10006 10 antigen antigen NN cord-010092-uftc8inx 10006 11 reactivity reactivity NN cord-010092-uftc8inx 10006 12 and and CC cord-010092-uftc8inx 10006 13 would would MD cord-010092-uftc8inx 10006 14 have have VB cord-010092-uftc8inx 10006 15 been be VBN cord-010092-uftc8inx 10006 16 mistyped mistype VBN cord-010092-uftc8inx 10006 17 as as IN cord-010092-uftc8inx 10006 18 RhD rhd NN cord-010092-uftc8inx 10006 19 negative negative JJ cord-010092-uftc8inx 10006 20 without without IN cord-010092-uftc8inx 10006 21 extensive extensive JJ cord-010092-uftc8inx 10006 22 genotypic genotypic JJ cord-010092-uftc8inx 10006 23 testing testing NN cord-010092-uftc8inx 10006 24 . . . cord-010092-uftc8inx 10007 1 Molecular molecular JJ cord-010092-uftc8inx 10007 2 analysis analysis NN cord-010092-uftc8inx 10007 3 of of IN cord-010092-uftc8inx 10007 4 variant variant NN cord-010092-uftc8inx 10008 1 c.1151C c.1151C NNP cord-010092-uftc8inx 10008 2 > > XX cord-010092-uftc8inx 10009 1 G g NN cord-010092-uftc8inx 10009 2 suggests suggest VBZ cord-010092-uftc8inx 10009 3 that that IN cord-010092-uftc8inx 10009 4 the the DT cord-010092-uftc8inx 10009 5 T384R T384R NNP cord-010092-uftc8inx 10009 6 exchange exchange NN cord-010092-uftc8inx 10009 7 causes cause VBZ cord-010092-uftc8inx 10009 8 a a DT cord-010092-uftc8inx 10009 9 DEL DEL NNP cord-010092-uftc8inx 10009 10 phenotype phenotype NN cord-010092-uftc8inx 10009 11 rather rather RB cord-010092-uftc8inx 10009 12 than than IN cord-010092-uftc8inx 10009 13 a a DT cord-010092-uftc8inx 10009 14 miss miss JJ cord-010092-uftc8inx 10009 15 splicing splicing NN cord-010092-uftc8inx 10009 16 event event NN cord-010092-uftc8inx 10009 17 . . . cord-010092-uftc8inx 10010 1 This this DT cord-010092-uftc8inx 10010 2 was be VBD cord-010092-uftc8inx 10010 3 also also RB cord-010092-uftc8inx 10010 4 confirmed confirm VBN cord-010092-uftc8inx 10010 5 by by IN cord-010092-uftc8inx 10010 6 adsorption adsorption NN cord-010092-uftc8inx 10010 7 - - HYPH cord-010092-uftc8inx 10010 8 elution elution NN cord-010092-uftc8inx 10010 9 testing testing NN cord-010092-uftc8inx 10010 10 . . . cord-010092-uftc8inx 10011 1 Interestingly interestingly RB cord-010092-uftc8inx 10011 2 , , , cord-010092-uftc8inx 10011 3 variant variant JJ cord-010092-uftc8inx 10011 4 c.526G c.526G NNP cord-010092-uftc8inx 10011 5 > > XX cord-010092-uftc8inx 10011 6 C C NNP cord-010092-uftc8inx 10011 7 could could MD cord-010092-uftc8inx 10011 8 only only RB cord-010092-uftc8inx 10011 9 be be VB cord-010092-uftc8inx 10011 10 detected detect VBN cord-010092-uftc8inx 10011 11 due due IN cord-010092-uftc8inx 10011 12 to to IN cord-010092-uftc8inx 10011 13 comprehensive comprehensive JJ cord-010092-uftc8inx 10011 14 serological serological JJ cord-010092-uftc8inx 10011 15 and and CC cord-010092-uftc8inx 10011 16 genetically genetically RB cord-010092-uftc8inx 10011 17 investigation investigation NN cord-010092-uftc8inx 10011 18 . . . cord-010092-uftc8inx 10012 1 Background background NN cord-010092-uftc8inx 10012 2 : : : cord-010092-uftc8inx 10013 1 The the DT cord-010092-uftc8inx 10013 2 Rh Rh NNP cord-010092-uftc8inx 10013 3 blood blood NN cord-010092-uftc8inx 10013 4 group group NN cord-010092-uftc8inx 10013 5 system system NN cord-010092-uftc8inx 10013 6 is be VBZ cord-010092-uftc8inx 10013 7 highly highly RB cord-010092-uftc8inx 10013 8 polymorphic polymorphic JJ cord-010092-uftc8inx 10013 9 and and CC cord-010092-uftc8inx 10013 10 one one CD cord-010092-uftc8inx 10013 11 of of IN cord-010092-uftc8inx 10013 12 the the DT cord-010092-uftc8inx 10013 13 most most RBS cord-010092-uftc8inx 10013 14 clinically clinically RB cord-010092-uftc8inx 10013 15 relevant relevant JJ cord-010092-uftc8inx 10013 16 systems system NNS cord-010092-uftc8inx 10013 17 in in IN cord-010092-uftc8inx 10013 18 transfusion transfusion NN cord-010092-uftc8inx 10013 19 . . . cord-010092-uftc8inx 10014 1 Actually actually RB cord-010092-uftc8inx 10014 2 D D NNP cord-010092-uftc8inx 10014 3 antigen antigen NN cord-010092-uftc8inx 10014 4 is be VBZ cord-010092-uftc8inx 10014 5 of of IN cord-010092-uftc8inx 10014 6 critical critical JJ cord-010092-uftc8inx 10014 7 importance importance NN cord-010092-uftc8inx 10014 8 due due IN cord-010092-uftc8inx 10014 9 to to IN cord-010092-uftc8inx 10014 10 its -PRON- PRP$ cord-010092-uftc8inx 10014 11 involvement involvement NN cord-010092-uftc8inx 10014 12 in in IN cord-010092-uftc8inx 10014 13 hemolytic hemolytic JJ cord-010092-uftc8inx 10014 14 transfusion transfusion NN cord-010092-uftc8inx 10014 15 reaction reaction NN cord-010092-uftc8inx 10014 16 and and CC cord-010092-uftc8inx 10014 17 hemolytic hemolytic JJ cord-010092-uftc8inx 10014 18 disease disease NN cord-010092-uftc8inx 10014 19 of of IN cord-010092-uftc8inx 10014 20 the the DT cord-010092-uftc8inx 10014 21 fetus fetus NN cord-010092-uftc8inx 10014 22 and and CC cord-010092-uftc8inx 10014 23 newborn newborn JJ cord-010092-uftc8inx 10014 24 . . . cord-010092-uftc8inx 10015 1 RHD RHD NNP cord-010092-uftc8inx 10015 2 gene gene NN cord-010092-uftc8inx 10015 3 variants variant NNS cord-010092-uftc8inx 10015 4 are be VBP cord-010092-uftc8inx 10015 5 common common JJ cord-010092-uftc8inx 10015 6 in in IN cord-010092-uftc8inx 10015 7 Africans Africans NNPS cord-010092-uftc8inx 10015 8 and and CC cord-010092-uftc8inx 10015 9 mostly mostly RB cord-010092-uftc8inx 10015 10 related related JJ cord-010092-uftc8inx 10015 11 to to IN cord-010092-uftc8inx 10015 12 partial partial JJ cord-010092-uftc8inx 10015 13 D d NN cord-010092-uftc8inx 10015 14 phenotype phenotype NN cord-010092-uftc8inx 10015 15 . . . cord-010092-uftc8inx 10016 1 Aims aim VBZ cord-010092-uftc8inx 10016 2 : : : cord-010092-uftc8inx 10016 3 RHD RHD NNP cord-010092-uftc8inx 10016 4 gene gene NN cord-010092-uftc8inx 10016 5 sequence sequence NN cord-010092-uftc8inx 10016 6 was be VBD cord-010092-uftc8inx 10016 7 investigated investigate VBN cord-010092-uftc8inx 10016 8 in in IN cord-010092-uftc8inx 10016 9 two two CD cord-010092-uftc8inx 10016 10 African african JJ cord-010092-uftc8inx 10016 11 Brazilian brazilian JJ cord-010092-uftc8inx 10016 12 samples sample NNS cord-010092-uftc8inx 10016 13 . . . cord-010092-uftc8inx 10017 1 We -PRON- PRP cord-010092-uftc8inx 10017 2 further further RB cord-010092-uftc8inx 10017 3 attempted attempt VBD cord-010092-uftc8inx 10017 4 to to TO cord-010092-uftc8inx 10017 5 take take VB cord-010092-uftc8inx 10017 6 advantage advantage NN cord-010092-uftc8inx 10017 7 of of IN cord-010092-uftc8inx 10017 8 combining combine VBG cord-010092-uftc8inx 10017 9 the the DT cord-010092-uftc8inx 10017 10 molecular molecular JJ cord-010092-uftc8inx 10017 11 data datum NNS cord-010092-uftc8inx 10017 12 and and CC cord-010092-uftc8inx 10017 13 the the DT cord-010092-uftc8inx 10017 14 available available JJ cord-010092-uftc8inx 10017 15 in in IN cord-010092-uftc8inx 10017 16 silico silico NN cord-010092-uftc8inx 10017 17 tools tool NNS cord-010092-uftc8inx 10017 18 for for IN cord-010092-uftc8inx 10017 19 the the DT cord-010092-uftc8inx 10017 20 functional functional JJ cord-010092-uftc8inx 10017 21 interpretation interpretation NN cord-010092-uftc8inx 10017 22 of of IN cord-010092-uftc8inx 10017 23 the the DT cord-010092-uftc8inx 10017 24 variations variation NNS cord-010092-uftc8inx 10017 25 , , , cord-010092-uftc8inx 10017 26 in in IN cord-010092-uftc8inx 10017 27 order order NN cord-010092-uftc8inx 10017 28 to to TO cord-010092-uftc8inx 10017 29 get get VB cord-010092-uftc8inx 10017 30 insights insight NNS cord-010092-uftc8inx 10017 31 into into IN cord-010092-uftc8inx 10017 32 the the DT cord-010092-uftc8inx 10017 33 clinical clinical JJ cord-010092-uftc8inx 10017 34 phenotype phenotype NN cord-010092-uftc8inx 10017 35 that that WDT cord-010092-uftc8inx 10017 36 may may MD cord-010092-uftc8inx 10017 37 be be VB cord-010092-uftc8inx 10017 38 predicted predict VBN cord-010092-uftc8inx 10017 39 a a DT cord-010092-uftc8inx 10017 40 priori priori NN cord-010092-uftc8inx 10017 41 from from IN cord-010092-uftc8inx 10017 42 genotyping genotype VBG cord-010092-uftc8inx 10017 43 . . . cord-010092-uftc8inx 10018 1 Methods method NNS cord-010092-uftc8inx 10018 2 : : : cord-010092-uftc8inx 10019 1 Sample sample NN cord-010092-uftc8inx 10019 2 # # $ cord-010092-uftc8inx 10019 3 ID1 id1 NN cord-010092-uftc8inx 10019 4 is be VBZ cord-010092-uftc8inx 10019 5 a a DT cord-010092-uftc8inx 10019 6 D d JJ cord-010092-uftc8inx 10019 7 - - HYPH cord-010092-uftc8inx 10019 8 negative negative JJ cord-010092-uftc8inx 10019 9 donor donor NN cord-010092-uftc8inx 10019 10 self self NN cord-010092-uftc8inx 10019 11 - - HYPH cord-010092-uftc8inx 10019 12 declared declare VBN cord-010092-uftc8inx 10019 13 as as IN cord-010092-uftc8inx 10019 14 African african JJ cord-010092-uftc8inx 10019 15 descent descent NN cord-010092-uftc8inx 10019 16 . . . cord-010092-uftc8inx 10020 1 Sample sample NN cord-010092-uftc8inx 10020 2 # # $ cord-010092-uftc8inx 10020 3 ID2 id2 NN cord-010092-uftc8inx 10020 4 is be VBZ cord-010092-uftc8inx 10020 5 a a DT cord-010092-uftc8inx 10020 6 patient patient NN cord-010092-uftc8inx 10020 7 with with IN cord-010092-uftc8inx 10020 8 sickle sickle NN cord-010092-uftc8inx 10020 9 cell cell NN cord-010092-uftc8inx 10020 10 disease disease NN cord-010092-uftc8inx 10020 11 ( ( -LRB- cord-010092-uftc8inx 10020 12 SCD SCD NNP cord-010092-uftc8inx 10020 13 ) ) -RRB- cord-010092-uftc8inx 10020 14 typed type VBN cord-010092-uftc8inx 10020 15 as as IN cord-010092-uftc8inx 10020 16 D d NN cord-010092-uftc8inx 10020 17 - - HYPH cord-010092-uftc8inx 10020 18 positive positive JJ cord-010092-uftc8inx 10020 19 with with IN cord-010092-uftc8inx 10020 20 anti anti JJ cord-010092-uftc8inx 10020 21 - - JJ cord-010092-uftc8inx 10020 22 D d JJ cord-010092-uftc8inx 10020 23 in in IN cord-010092-uftc8inx 10020 24 his -PRON- PRP$ cord-010092-uftc8inx 10020 25 serum serum NN cord-010092-uftc8inx 10020 26 . . . cord-010092-uftc8inx 10021 1 Serologic Serologic NNP cord-010092-uftc8inx 10021 2 D D NNP cord-010092-uftc8inx 10021 3 typing typing NN cord-010092-uftc8inx 10021 4 was be VBD cord-010092-uftc8inx 10021 5 determined determine VBN cord-010092-uftc8inx 10021 6 by by IN cord-010092-uftc8inx 10021 7 manual manual JJ cord-010092-uftc8inx 10021 8 gel gel NN cord-010092-uftc8inx 10021 9 test test NN cord-010092-uftc8inx 10021 10 and and CC cord-010092-uftc8inx 10021 11 by by IN cord-010092-uftc8inx 10021 12 microplate microplate NNP cord-010092-uftc8inx 10021 13 in in IN cord-010092-uftc8inx 10021 14 an an DT cord-010092-uftc8inx 10021 15 automated automate VBN cord-010092-uftc8inx 10021 16 instrument instrument NN cord-010092-uftc8inx 10021 17 . . . cord-010092-uftc8inx 10022 1 Sample sample NN cord-010092-uftc8inx 10022 2 # # NN cord-010092-uftc8inx 10022 3 ID1 id1 NN cord-010092-uftc8inx 10022 4 was be VBD cord-010092-uftc8inx 10022 5 also also RB cord-010092-uftc8inx 10022 6 submitted submit VBN cord-010092-uftc8inx 10022 7 to to IN cord-010092-uftc8inx 10022 8 adsorption adsorption NN cord-010092-uftc8inx 10022 9 / / SYM cord-010092-uftc8inx 10022 10 elution elution NN cord-010092-uftc8inx 10022 11 test test NN cord-010092-uftc8inx 10022 12 . . . cord-010092-uftc8inx 10023 1 After after IN cord-010092-uftc8inx 10023 2 genomic genomic JJ cord-010092-uftc8inx 10023 3 DNA dna NN cord-010092-uftc8inx 10023 4 extraction extraction NN cord-010092-uftc8inx 10023 5 , , , cord-010092-uftc8inx 10023 6 all all DT cord-010092-uftc8inx 10023 7 ten ten CD cord-010092-uftc8inx 10023 8 RHD RHD NNP cord-010092-uftc8inx 10023 9 exons exon NNS cord-010092-uftc8inx 10023 10 and and CC cord-010092-uftc8inx 10023 11 flanking flank VBG cord-010092-uftc8inx 10023 12 intronic intronic JJ cord-010092-uftc8inx 10023 13 regions region NNS cord-010092-uftc8inx 10023 14 from from IN cord-010092-uftc8inx 10023 15 sample sample NN cord-010092-uftc8inx 10023 16 # # $ cord-010092-uftc8inx 10023 17 ID1 ID1 NNP cord-010092-uftc8inx 10023 18 were be VBD cord-010092-uftc8inx 10023 19 PCR PCR NNP cord-010092-uftc8inx 10023 20 - - HYPH cord-010092-uftc8inx 10023 21 amplified amplify VBN cord-010092-uftc8inx 10023 22 with with IN cord-010092-uftc8inx 10023 23 RHD rhd NN cord-010092-uftc8inx 10023 24 - - HYPH cord-010092-uftc8inx 10023 25 specific specific JJ cord-010092-uftc8inx 10023 26 primers primer NNS cord-010092-uftc8inx 10023 27 and and CC cord-010092-uftc8inx 10023 28 analyzed analyze VBN cord-010092-uftc8inx 10023 29 by by IN cord-010092-uftc8inx 10023 30 Sanger Sanger NNP cord-010092-uftc8inx 10023 31 sequencing sequencing NN cord-010092-uftc8inx 10023 32 . . . cord-010092-uftc8inx 10024 1 Sample sample NN cord-010092-uftc8inx 10024 2 # # NN cord-010092-uftc8inx 10024 3 ID2 id2 NN cord-010092-uftc8inx 10024 4 was be VBD cord-010092-uftc8inx 10024 5 investigated investigate VBN cord-010092-uftc8inx 10024 6 by by IN cord-010092-uftc8inx 10024 7 next next JJ cord-010092-uftc8inx 10024 8 - - HYPH cord-010092-uftc8inx 10024 9 generation generation NN cord-010092-uftc8inx 10024 10 sequencing sequencing NN cord-010092-uftc8inx 10024 11 on on IN cord-010092-uftc8inx 10024 12 the the DT cord-010092-uftc8inx 10024 13 MiniSeq MiniSeq NNP cord-010092-uftc8inx 10024 14 platform platform NN cord-010092-uftc8inx 10024 15 ( ( -LRB- cord-010092-uftc8inx 10024 16 Illumina Illumina NNP cord-010092-uftc8inx 10024 17 ) ) -RRB- cord-010092-uftc8inx 10024 18 by by IN cord-010092-uftc8inx 10024 19 using use VBG cord-010092-uftc8inx 10024 20 a a DT cord-010092-uftc8inx 10024 21 previously previously RB cord-010092-uftc8inx 10024 22 published publish VBN cord-010092-uftc8inx 10024 23 , , , cord-010092-uftc8inx 10024 24 custom custom JJ cord-010092-uftc8inx 10024 25 ( ( -LRB- cord-010092-uftc8inx 10024 26 selected select VBN cord-010092-uftc8inx 10024 27 blood blood NN cord-010092-uftc8inx 10024 28 group group NN cord-010092-uftc8inx 10024 29 genes gene NNS cord-010092-uftc8inx 10024 30 ) ) -RRB- cord-010092-uftc8inx 10025 1 AmpliSeq AmpliSeq NNP cord-010092-uftc8inx 10025 2 panel panel NN cord-010092-uftc8inx 10025 3 . . . cord-010092-uftc8inx 10026 1 A a DT cord-010092-uftc8inx 10026 2 reported report VBN cord-010092-uftc8inx 10026 3 three three CD cord-010092-uftc8inx 10026 4 - - HYPH cord-010092-uftc8inx 10026 5 dimensional dimensional JJ cord-010092-uftc8inx 10026 6 ( ( -LRB- cord-010092-uftc8inx 10026 7 3D 3D NNP cord-010092-uftc8inx 10026 8 ) ) -RRB- cord-010092-uftc8inx 10026 9 structural structural JJ cord-010092-uftc8inx 10026 10 model model NN cord-010092-uftc8inx 10026 11 of of IN cord-010092-uftc8inx 10026 12 the the DT cord-010092-uftc8inx 10026 13 RhD RhD NNP cord-010092-uftc8inx 10026 14 - - HYPH cord-010092-uftc8inx 10026 15 RhD RhD NNP cord-010092-uftc8inx 10026 16 - - HYPH cord-010092-uftc8inx 10026 17 RhAG RhAG NNP cord-010092-uftc8inx 10026 18 heterotrimer heterotrimer NNP cord-010092-uftc8inx 10026 19 was be VBD cord-010092-uftc8inx 10026 20 used use VBN cord-010092-uftc8inx 10026 21 to to TO cord-010092-uftc8inx 10026 22 visualize visualize VB cord-010092-uftc8inx 10026 23 the the DT cord-010092-uftc8inx 10026 24 position position NN cord-010092-uftc8inx 10026 25 of of IN cord-010092-uftc8inx 10026 26 variations variation NNS cord-010092-uftc8inx 10026 27 and and CC cord-010092-uftc8inx 10026 28 predict predict VBP cord-010092-uftc8inx 10026 29 their -PRON- PRP$ cord-010092-uftc8inx 10026 30 putative putative JJ cord-010092-uftc8inx 10026 31 functional functional JJ cord-010092-uftc8inx 10026 32 / / SYM cord-010092-uftc8inx 10026 33 clinical clinical JJ cord-010092-uftc8inx 10026 34 effect effect NN cord-010092-uftc8inx 10026 35 . . . cord-010092-uftc8inx 10027 1 Results result NNS cord-010092-uftc8inx 10027 2 : : : cord-010092-uftc8inx 10028 1 In in IN cord-010092-uftc8inx 10028 2 sample sample NN cord-010092-uftc8inx 10028 3 # # $ cord-010092-uftc8inx 10028 4 ID1 ID1 NNP cord-010092-uftc8inx 10028 5 , , , cord-010092-uftc8inx 10028 6 a a DT cord-010092-uftc8inx 10028 7 single single JJ cord-010092-uftc8inx 10028 8 nucleotide nucleotide JJ cord-010092-uftc8inx 10028 9 missense missense NN cord-010092-uftc8inx 10028 10 change change NN cord-010092-uftc8inx 10028 11 , , , cord-010092-uftc8inx 10028 12 i.e. i.e. FW cord-010092-uftc8inx 10028 13 c.1151C c.1151c FW cord-010092-uftc8inx 10029 1 > > XX cord-010092-uftc8inx 10030 1 G G NNP cord-010092-uftc8inx 10030 2 in in IN cord-010092-uftc8inx 10030 3 exon exon NN cord-010092-uftc8inx 10030 4 8 8 CD cord-010092-uftc8inx 10030 5 , , , cord-010092-uftc8inx 10030 6 was be VBD cord-010092-uftc8inx 10030 7 identified identify VBN cord-010092-uftc8inx 10030 8 . . . cord-010092-uftc8inx 10031 1 This this DT cord-010092-uftc8inx 10031 2 transversion transversion NN cord-010092-uftc8inx 10031 3 is be VBZ cord-010092-uftc8inx 10031 4 thought think VBN cord-010092-uftc8inx 10031 5 to to TO cord-010092-uftc8inx 10031 6 replace replace VB cord-010092-uftc8inx 10031 7 a a DT cord-010092-uftc8inx 10031 8 threonine threonine NN cord-010092-uftc8inx 10031 9 by by IN cord-010092-uftc8inx 10031 10 an an DT cord-010092-uftc8inx 10031 11 arginine arginine NN cord-010092-uftc8inx 10031 12 residue residue NN cord-010092-uftc8inx 10031 13 at at IN cord-010092-uftc8inx 10031 14 amino amino NN cord-010092-uftc8inx 10031 15 acid acid NN cord-010092-uftc8inx 10031 16 position position NN cord-010092-uftc8inx 10031 17 384 384 CD cord-010092-uftc8inx 10031 18 ( ( -LRB- cord-010092-uftc8inx 10031 19 p p NN cord-010092-uftc8inx 10031 20 . . . cord-010092-uftc8inx 10031 21 Thr384Arg thr384arg CD cord-010092-uftc8inx 10031 22 ) ) -RRB- cord-010092-uftc8inx 10031 23 of of IN cord-010092-uftc8inx 10031 24 the the DT cord-010092-uftc8inx 10031 25 RhD RhD NNP cord-010092-uftc8inx 10031 26 protein protein NNP cord-010092-uftc8inx 10031 27 . . . cord-010092-uftc8inx 10032 1 Analysis analysis NN cord-010092-uftc8inx 10032 2 in in IN cord-010092-uftc8inx 10032 3 the the DT cord-010092-uftc8inx 10032 4 3D 3d JJ cord-010092-uftc8inx 10032 5 model model NN cord-010092-uftc8inx 10032 6 clearly clearly RB cord-010092-uftc8inx 10032 7 suggests suggest VBZ cord-010092-uftc8inx 10032 8 a a DT cord-010092-uftc8inx 10032 9 dramatic dramatic JJ cord-010092-uftc8inx 10032 10 impact impact NN cord-010092-uftc8inx 10032 11 of of IN cord-010092-uftc8inx 10032 12 the the DT cord-010092-uftc8inx 10032 13 p. p. NN cord-010092-uftc8inx 10033 1 Thr384Arg thr384arg CD cord-010092-uftc8inx 10033 2 substitution substitution NN cord-010092-uftc8inx 10033 3 occurring occur VBG cord-010092-uftc8inx 10033 4 in in IN cord-010092-uftc8inx 10033 5 a a DT cord-010092-uftc8inx 10033 6 functionally functionally RB cord-010092-uftc8inx 10033 7 - - HYPH cord-010092-uftc8inx 10033 8 critical critical JJ cord-010092-uftc8inx 10033 9 , , , cord-010092-uftc8inx 10033 10 conserved conserved JJ cord-010092-uftc8inx 10033 11 motif motif NN cord-010092-uftc8inx 10033 12 in in IN cord-010092-uftc8inx 10033 13 terms term NNS cord-010092-uftc8inx 10033 14 of of IN cord-010092-uftc8inx 10033 15 interhelix interhelix JJ cord-010092-uftc8inx 10033 16 interaction interaction NN cord-010092-uftc8inx 10033 17 , , , cord-010092-uftc8inx 10033 18 which which WDT cord-010092-uftc8inx 10033 19 is be VBZ cord-010092-uftc8inx 10033 20 supposed suppose VBN cord-010092-uftc8inx 10033 21 to to TO cord-010092-uftc8inx 10033 22 be be VB cord-010092-uftc8inx 10033 23 highly highly RB cord-010092-uftc8inx 10033 24 deleterious deleterious JJ cord-010092-uftc8inx 10033 25 to to IN cord-010092-uftc8inx 10033 26 the the DT cord-010092-uftc8inx 10033 27 stability stability NN cord-010092-uftc8inx 10033 28 of of IN cord-010092-uftc8inx 10033 29 the the DT cord-010092-uftc8inx 10033 30 protein protein NN cord-010092-uftc8inx 10033 31 , , , cord-010092-uftc8inx 10033 32 and and CC cord-010092-uftc8inx 10033 33 potentially potentially RB cord-010092-uftc8inx 10033 34 impairs impair VBZ cord-010092-uftc8inx 10033 35 totally totally RB cord-010092-uftc8inx 10033 36 its -PRON- PRP$ cord-010092-uftc8inx 10033 37 expression expression NN cord-010092-uftc8inx 10033 38 at at IN cord-010092-uftc8inx 10033 39 the the DT cord-010092-uftc8inx 10033 40 red red JJ cord-010092-uftc8inx 10033 41 blood blood NN cord-010092-uftc8inx 10033 42 cell cell NN cord-010092-uftc8inx 10033 43 plasma plasma NN cord-010092-uftc8inx 10033 44 membrane membrane NN cord-010092-uftc8inx 10033 45 . . . cord-010092-uftc8inx 10034 1 This this DT cord-010092-uftc8inx 10034 2 predicted predict VBD cord-010092-uftc8inx 10034 3 functional functional JJ cord-010092-uftc8inx 10034 4 effect effect NN cord-010092-uftc8inx 10034 5 is be VBZ cord-010092-uftc8inx 10034 6 definitely definitely RB cord-010092-uftc8inx 10034 7 in in IN cord-010092-uftc8inx 10034 8 accordance accordance NN cord-010092-uftc8inx 10034 9 with with IN cord-010092-uftc8inx 10034 10 the the DT cord-010092-uftc8inx 10034 11 D d JJ cord-010092-uftc8inx 10034 12 - - HYPH cord-010092-uftc8inx 10034 13 negative negative JJ cord-010092-uftc8inx 10034 14 phenotype phenotype NN cord-010092-uftc8inx 10034 15 reported report VBN cord-010092-uftc8inx 10034 16 in in IN cord-010092-uftc8inx 10034 17 sample sample NN cord-010092-uftc8inx 10034 18 # # $ cord-010092-uftc8inx 10034 19 ID1 ID1 NNP cord-010092-uftc8inx 10034 20 . . . cord-010092-uftc8inx 10035 1 In in IN cord-010092-uftc8inx 10035 2 sample sample NN cord-010092-uftc8inx 10035 3 # # $ cord-010092-uftc8inx 10035 4 ID2 id2 NN cord-010092-uftc8inx 10035 5 , , , cord-010092-uftc8inx 10035 6 the the DT cord-010092-uftc8inx 10035 7 single single JJ cord-010092-uftc8inx 10035 8 c.325A c.325a NN cord-010092-uftc8inx 10035 9 > > XX cord-010092-uftc8inx 10036 1 G g NN cord-010092-uftc8inx 10036 2 transition transition NN cord-010092-uftc8inx 10036 3 was be VBD cord-010092-uftc8inx 10036 4 found find VBN cord-010092-uftc8inx 10036 5 in in IN cord-010092-uftc8inx 10036 6 exon exon NN cord-010092-uftc8inx 10036 7 2 2 CD cord-010092-uftc8inx 10036 8 leading lead VBG cord-010092-uftc8inx 10036 9 to to IN cord-010092-uftc8inx 10036 10 a a DT cord-010092-uftc8inx 10036 11 threonine threonine NN cord-010092-uftc8inx 10036 12 - - HYPH cord-010092-uftc8inx 10036 13 to to IN cord-010092-uftc8inx 10036 14 - - HYPH cord-010092-uftc8inx 10036 15 alanine alanine NN cord-010092-uftc8inx 10036 16 substitution substitution NN cord-010092-uftc8inx 10036 17 at at IN cord-010092-uftc8inx 10036 18 amino amino NN cord-010092-uftc8inx 10036 19 acid acid NN cord-010092-uftc8inx 10036 20 position position NN cord-010092-uftc8inx 10036 21 109 109 CD cord-010092-uftc8inx 10036 22 ( ( -LRB- cord-010092-uftc8inx 10036 23 p. p. NN cord-010092-uftc8inx 10037 1 Thr109Ala Thr109Ala NNP cord-010092-uftc8inx 10037 2 ) ) -RRB- cord-010092-uftc8inx 10037 3 . . . cord-010092-uftc8inx 10038 1 Amino amino NN cord-010092-uftc8inx 10038 2 acid acid NN cord-010092-uftc8inx 10038 3 109 109 CD cord-010092-uftc8inx 10038 4 is be VBZ cord-010092-uftc8inx 10038 5 located locate VBN cord-010092-uftc8inx 10038 6 in in IN cord-010092-uftc8inx 10038 7 RhD RhD NNP cord-010092-uftc8inx 10038 8 protein protein NN cord-010092-uftc8inx 10038 9 extracellular extracellular JJ cord-010092-uftc8inx 10038 10 loop loop NN cord-010092-uftc8inx 10038 11 2 2 CD cord-010092-uftc8inx 10038 12 , , , cord-010092-uftc8inx 10038 13 and and CC cord-010092-uftc8inx 10038 14 is be VBZ cord-010092-uftc8inx 10038 15 thus thus RB cord-010092-uftc8inx 10038 16 thought think VBN cord-010092-uftc8inx 10038 17 to to TO cord-010092-uftc8inx 10038 18 alter alter VB cord-010092-uftc8inx 10038 19 D D NNP cord-010092-uftc8inx 10038 20 antigen antigen NN cord-010092-uftc8inx 10038 21 structure structure NN cord-010092-uftc8inx 10038 22 , , , cord-010092-uftc8inx 10038 23 resulting result VBG cord-010092-uftc8inx 10038 24 in in IN cord-010092-uftc8inx 10038 25 a a DT cord-010092-uftc8inx 10038 26 partial partial JJ cord-010092-uftc8inx 10038 27 D d NN cord-010092-uftc8inx 10038 28 phenotype phenotype NN cord-010092-uftc8inx 10038 29 . . . cord-010092-uftc8inx 10039 1 This this DT cord-010092-uftc8inx 10039 2 hypothesis hypothesis NN cord-010092-uftc8inx 10039 3 is be VBZ cord-010092-uftc8inx 10039 4 in in IN cord-010092-uftc8inx 10039 5 accordance accordance NN cord-010092-uftc8inx 10039 6 with with IN cord-010092-uftc8inx 10039 7 anti anti JJ cord-010092-uftc8inx 10039 8 - - JJ cord-010092-uftc8inx 10039 9 D d JJ cord-010092-uftc8inx 10039 10 found find VBN cord-010092-uftc8inx 10039 11 in in IN cord-010092-uftc8inx 10039 12 the the DT cord-010092-uftc8inx 10039 13 serum serum NN cord-010092-uftc8inx 10039 14 of of IN cord-010092-uftc8inx 10039 15 sample sample NN cord-010092-uftc8inx 10039 16 # # $ cord-010092-uftc8inx 10039 17 ID2 id2 NN cord-010092-uftc8inx 10039 18 . . . cord-010092-uftc8inx 10040 1 Summary Summary NNP cord-010092-uftc8inx 10040 2 / / SYM cord-010092-uftc8inx 10040 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 10040 4 : : : cord-010092-uftc8inx 10041 1 For for IN cord-010092-uftc8inx 10041 2 the the DT cord-010092-uftc8inx 10041 3 past past JJ cord-010092-uftc8inx 10041 4 years year NNS cord-010092-uftc8inx 10041 5 , , , cord-010092-uftc8inx 10041 6 due due IN cord-010092-uftc8inx 10041 7 to to IN cord-010092-uftc8inx 10041 8 the the DT cord-010092-uftc8inx 10041 9 advent advent NN cord-010092-uftc8inx 10041 10 of of IN cord-010092-uftc8inx 10041 11 next next JJ cord-010092-uftc8inx 10041 12 - - HYPH cord-010092-uftc8inx 10041 13 generation generation NN cord-010092-uftc8inx 10041 14 sequencing sequencing NN cord-010092-uftc8inx 10041 15 and and CC cord-010092-uftc8inx 10041 16 the the DT cord-010092-uftc8inx 10041 17 subsequent subsequent JJ cord-010092-uftc8inx 10041 18 identification identification NN cord-010092-uftc8inx 10041 19 of of IN cord-010092-uftc8inx 10041 20 numerous numerous JJ cord-010092-uftc8inx 10041 21 rare rare JJ cord-010092-uftc8inx 10041 22 variants variant NNS cord-010092-uftc8inx 10041 23 , , , cord-010092-uftc8inx 10041 24 bioinformatics bioinformatics NN cord-010092-uftc8inx 10041 25 prediction prediction NN cord-010092-uftc8inx 10041 26 and and CC cord-010092-uftc8inx 10041 27 modelling modelling NN cord-010092-uftc8inx 10041 28 tools tool NNS cord-010092-uftc8inx 10041 29 have have VBP cord-010092-uftc8inx 10041 30 evolved evolve VBN cord-010092-uftc8inx 10041 31 and and CC cord-010092-uftc8inx 10041 32 currently currently RB cord-010092-uftc8inx 10041 33 help help VB cord-010092-uftc8inx 10041 34 physicians physician NNS cord-010092-uftc8inx 10041 35 in in IN cord-010092-uftc8inx 10041 36 diagnostics diagnostic NNS cord-010092-uftc8inx 10041 37 , , , cord-010092-uftc8inx 10041 38 clinical clinical JJ cord-010092-uftc8inx 10041 39 management management NN cord-010092-uftc8inx 10041 40 and and CC cord-010092-uftc8inx 10041 41 genetic genetic JJ cord-010092-uftc8inx 10041 42 counselling counselling NN cord-010092-uftc8inx 10041 43 . . . cord-010092-uftc8inx 10042 1 We -PRON- PRP cord-010092-uftc8inx 10042 2 took take VBD cord-010092-uftc8inx 10042 3 advantage advantage NN cord-010092-uftc8inx 10042 4 of of IN cord-010092-uftc8inx 10042 5 some some DT cord-010092-uftc8inx 10042 6 of of IN cord-010092-uftc8inx 10042 7 those those DT cord-010092-uftc8inx 10042 8 in in IN cord-010092-uftc8inx 10042 9 silico silico NN cord-010092-uftc8inx 10042 10 methods method NNS cord-010092-uftc8inx 10042 11 to to TO cord-010092-uftc8inx 10042 12 predict predict VB cord-010092-uftc8inx 10042 13 retrospectively retrospectively RB cord-010092-uftc8inx 10042 14 the the DT cord-010092-uftc8inx 10042 15 effect effect NN cord-010092-uftc8inx 10042 16 of of IN cord-010092-uftc8inx 10042 17 two two CD cord-010092-uftc8inx 10042 18 novel novel JJ cord-010092-uftc8inx 10042 19 variant variant NN cord-010092-uftc8inx 10042 20 RHD RHD NNP cord-010092-uftc8inx 10042 21 alleles allele NNS cord-010092-uftc8inx 10042 22 , , , cord-010092-uftc8inx 10042 23 including include VBG cord-010092-uftc8inx 10042 24 one one CD cord-010092-uftc8inx 10042 25 D d JJ cord-010092-uftc8inx 10042 26 - - HYPH cord-010092-uftc8inx 10042 27 negative negative JJ cord-010092-uftc8inx 10042 28 and and CC cord-010092-uftc8inx 10042 29 one one CD cord-010092-uftc8inx 10042 30 partial partial JJ cord-010092-uftc8inx 10042 31 D d NN cord-010092-uftc8inx 10042 32 alleles allele NNS cord-010092-uftc8inx 10042 33 . . . cord-010092-uftc8inx 10043 1 Although although IN cord-010092-uftc8inx 10043 2 phenotype phenotype NN cord-010092-uftc8inx 10043 3 and and CC cord-010092-uftc8inx 10043 4 clinical clinical JJ cord-010092-uftc8inx 10043 5 symptoms symptom NNS cord-010092-uftc8inx 10043 6 remain remain VBP cord-010092-uftc8inx 10043 7 definitely definitely RB cord-010092-uftc8inx 10043 8 the the DT cord-010092-uftc8inx 10043 9 standard standard JJ cord-010092-uftc8inx 10043 10 determinants determinant NNS cord-010092-uftc8inx 10043 11 to to TO cord-010092-uftc8inx 10043 12 assess assess VB cord-010092-uftc8inx 10043 13 the the DT cord-010092-uftc8inx 10043 14 effect effect NN cord-010092-uftc8inx 10043 15 of of IN cord-010092-uftc8inx 10043 16 genetic genetic JJ cord-010092-uftc8inx 10043 17 variations variation NNS cord-010092-uftc8inx 10043 18 , , , cord-010092-uftc8inx 10043 19 use use NN cord-010092-uftc8inx 10043 20 of of IN cord-010092-uftc8inx 10043 21 those those DT cord-010092-uftc8inx 10043 22 approaches approach NNS cord-010092-uftc8inx 10043 23 may may MD cord-010092-uftc8inx 10043 24 soon soon RB cord-010092-uftc8inx 10043 25 become become VB cord-010092-uftc8inx 10043 26 valuable valuable JJ cord-010092-uftc8inx 10043 27 for for IN cord-010092-uftc8inx 10043 28 guiding guide VBG cord-010092-uftc8inx 10043 29 subsequent subsequent JJ cord-010092-uftc8inx 10043 30 investigations investigation NNS cord-010092-uftc8inx 10043 31 in in IN cord-010092-uftc8inx 10043 32 immunohaematology immunohaematology NN cord-010092-uftc8inx 10043 33 . . . cord-010092-uftc8inx 10044 1 Abstract Abstract NNP cord-010092-uftc8inx 10044 2 withdrawn withdraw VBN cord-010092-uftc8inx 10044 3 . . . cord-010092-uftc8inx 10045 1 alleles allele NNS cord-010092-uftc8inx 10045 2 of of IN cord-010092-uftc8inx 10045 3 the the DT cord-010092-uftc8inx 10045 4 weak weak JJ cord-010092-uftc8inx 10045 5 D D NNP cord-010092-uftc8inx 10045 6 type type NN cord-010092-uftc8inx 10045 7 4 4 CD cord-010092-uftc8inx 10045 8 and and CC cord-010092-uftc8inx 10045 9 DIVa DIVa VBZ cord-010092-uftc8inx 10045 10 cluster cluster NN cord-010092-uftc8inx 10045 11 . . . cord-010092-uftc8inx 10046 1 In in IN cord-010092-uftc8inx 10046 2 Africans Africans NNPS cord-010092-uftc8inx 10046 3 , , , cord-010092-uftc8inx 10046 4 the the DT cord-010092-uftc8inx 10046 5 16 16 CD cord-010092-uftc8inx 10046 6 most most RBS cord-010092-uftc8inx 10046 7 frequent frequent JJ cord-010092-uftc8inx 10046 8 were be VBD cord-010092-uftc8inx 10046 9 typically typically RB cord-010092-uftc8inx 10046 10 associated associate VBN cord-010092-uftc8inx 10046 11 with with IN cord-010092-uftc8inx 10046 12 alleles allele NNS cord-010092-uftc8inx 10046 13 of of IN cord-010092-uftc8inx 10046 14 the the DT cord-010092-uftc8inx 10046 15 weak weak JJ cord-010092-uftc8inx 10046 16 D D NNP cord-010092-uftc8inx 10046 17 type type NN cord-010092-uftc8inx 10046 18 4 4 CD cord-010092-uftc8inx 10046 19 ( ( -LRB- cord-010092-uftc8inx 10046 20 including include VBG cord-010092-uftc8inx 10046 21 DOL DOL NNP cord-010092-uftc8inx 10046 22 and and CC cord-010092-uftc8inx 10046 23 RHDpsi RHDpsi NNP cord-010092-uftc8inx 10046 24 ) ) -RRB- cord-010092-uftc8inx 10046 25 , , , cord-010092-uftc8inx 10046 26 DIVa DIVa NNS cord-010092-uftc8inx 10046 27 and and CC cord-010092-uftc8inx 10046 28 DAU dau NN cord-010092-uftc8inx 10046 29 clusters cluster NNS cord-010092-uftc8inx 10046 30 with with IN cord-010092-uftc8inx 10046 31 F223V f223v NN cord-010092-uftc8inx 10046 32 occurring occur VBG cord-010092-uftc8inx 10046 33 in in IN cord-010092-uftc8inx 10046 34 > > XX cord-010092-uftc8inx 10046 35 10 10 CD cord-010092-uftc8inx 10046 36 % % NN cord-010092-uftc8inx 10046 37 of of IN cord-010092-uftc8inx 10046 38 alleles allele NNS cord-010092-uftc8inx 10046 39 ; ; : cord-010092-uftc8inx 10046 40 in in IN cord-010092-uftc8inx 10046 41 addition addition NN cord-010092-uftc8inx 10046 42 the the DT cord-010092-uftc8inx 10046 43 key key JJ cord-010092-uftc8inx 10046 44 mutations mutation NNS cord-010092-uftc8inx 10046 45 of of IN cord-010092-uftc8inx 10046 46 weak weak JJ cord-010092-uftc8inx 10046 47 D d NN cord-010092-uftc8inx 10046 48 type type NN cord-010092-uftc8inx 10046 49 1 1 CD cord-010092-uftc8inx 10046 50 and and CC cord-010092-uftc8inx 10046 51 DII DII NNP cord-010092-uftc8inx 10046 52 and and CC cord-010092-uftc8inx 10046 53 two two CD cord-010092-uftc8inx 10046 54 inactivating inactivate VBG cord-010092-uftc8inx 10046 55 mutations mutation NNS cord-010092-uftc8inx 10046 56 ( ( -LRB- cord-010092-uftc8inx 10046 57 c.1056_1057insT c.1056_1057inst NN cord-010092-uftc8inx 10046 58 and and CC cord-010092-uftc8inx 10046 59 c.1060delG c.1060delG NNP cord-010092-uftc8inx 10046 60 ) ) -RRB- cord-010092-uftc8inx 10046 61 not not RB cord-010092-uftc8inx 10046 62 reported report VBN cord-010092-uftc8inx 10046 63 in in IN cord-010092-uftc8inx 10046 64 RHB RHB NNP cord-010092-uftc8inx 10046 65 were be VBD cord-010092-uftc8inx 10046 66 among among IN cord-010092-uftc8inx 10046 67 the the DT cord-010092-uftc8inx 10046 68 first first JJ cord-010092-uftc8inx 10046 69 20 20 CD cord-010092-uftc8inx 10046 70 polymorphisms polymorphism NNS cord-010092-uftc8inx 10046 71 . . . cord-010092-uftc8inx 10047 1 In in IN cord-010092-uftc8inx 10047 2 East East NNP cord-010092-uftc8inx 10047 3 Asians Asians NNPS cord-010092-uftc8inx 10047 4 , , , cord-010092-uftc8inx 10047 5 RHD(1227G RHD(1227G NNP cord-010092-uftc8inx 10047 6 > > XX cord-010092-uftc8inx 10047 7 A a NN cord-010092-uftc8inx 10047 8 ) ) -RRB- cord-010092-uftc8inx 10047 9 at at IN cord-010092-uftc8inx 10047 10 0.8 0.8 CD cord-010092-uftc8inx 10047 11 % % NN cord-010092-uftc8inx 10047 12 was be VBD cord-010092-uftc8inx 10047 13 most most RBS cord-010092-uftc8inx 10047 14 frequent frequent JJ cord-010092-uftc8inx 10047 15 , , , cord-010092-uftc8inx 10047 16 followed follow VBN cord-010092-uftc8inx 10047 17 by by IN cord-010092-uftc8inx 10047 18 DFV DFV NNP cord-010092-uftc8inx 10047 19 , , , cord-010092-uftc8inx 10047 20 weak weak JJ cord-010092-uftc8inx 10047 21 D d NN cord-010092-uftc8inx 10047 22 type type NN cord-010092-uftc8inx 10047 23 33 33 CD cord-010092-uftc8inx 10047 24 , , , cord-010092-uftc8inx 10047 25 DBO-3 DBO-3 NNP cord-010092-uftc8inx 10047 26 , , , cord-010092-uftc8inx 10047 27 key key JJ cord-010092-uftc8inx 10047 28 mutations mutation NNS cord-010092-uftc8inx 10047 29 of of IN cord-010092-uftc8inx 10047 30 DIVa DIVa NNS cord-010092-uftc8inx 10047 31 and and CC cord-010092-uftc8inx 10047 32 weak weak JJ cord-010092-uftc8inx 10047 33 D d NN cord-010092-uftc8inx 10047 34 type type NN cord-010092-uftc8inx 10047 35 4 4 CD cord-010092-uftc8inx 10047 36 cluster cluster NN cord-010092-uftc8inx 10047 37 as as RB cord-010092-uftc8inx 10047 38 well well RB cord-010092-uftc8inx 10047 39 as as IN cord-010092-uftc8inx 10047 40 RHCE RHCE NNP cord-010092-uftc8inx 10047 41 - - HYPH cord-010092-uftc8inx 10047 42 like like JJ cord-010092-uftc8inx 10047 43 substitutions substitution NNS cord-010092-uftc8inx 10047 44 and and CC cord-010092-uftc8inx 10047 45 the the DT cord-010092-uftc8inx 10047 46 mutations mutation NNS cord-010092-uftc8inx 10047 47 of of IN cord-010092-uftc8inx 10047 48 weak weak JJ cord-010092-uftc8inx 10047 49 D d NN cord-010092-uftc8inx 10047 50 type type NN cord-010092-uftc8inx 10047 51 25 25 CD cord-010092-uftc8inx 10047 52 , , , cord-010092-uftc8inx 10047 53 type type NN cord-010092-uftc8inx 10047 54 15 15 CD cord-010092-uftc8inx 10047 55 , , , cord-010092-uftc8inx 10047 56 type type NN cord-010092-uftc8inx 10047 57 66 66 CD cord-010092-uftc8inx 10047 58 , , , cord-010092-uftc8inx 10047 59 RHD(A85V RHD(A85V NNP cord-010092-uftc8inx 10047 60 ) ) -RRB- cord-010092-uftc8inx 10047 61 , , , cord-010092-uftc8inx 10047 62 DVL-1 DVL-1 NNP cord-010092-uftc8inx 10047 63 , , , cord-010092-uftc8inx 10047 64 weak weak JJ cord-010092-uftc8inx 10047 65 D D NNP cord-010092-uftc8inx 10047 66 119 119 CD cord-010092-uftc8inx 10047 67 and and CC cord-010092-uftc8inx 10047 68 RHD(N135S RHD(N135S NNP cord-010092-uftc8inx 10047 69 ) ) -RRB- cord-010092-uftc8inx 10047 70 . . . cord-010092-uftc8inx 10048 1 Weak weak JJ cord-010092-uftc8inx 10048 2 D d NN cord-010092-uftc8inx 10048 3 type type NN cord-010092-uftc8inx 10048 4 151 151 CD cord-010092-uftc8inx 10048 5 and and CC cord-010092-uftc8inx 10048 6 RHD(T148R RHD(T148R NNP cord-010092-uftc8inx 10048 7 ) ) -RRB- cord-010092-uftc8inx 10048 8 were be VBD cord-010092-uftc8inx 10048 9 frequent frequent JJ cord-010092-uftc8inx 10048 10 in in IN cord-010092-uftc8inx 10048 11 South South NNP cord-010092-uftc8inx 10048 12 Asia Asia NNP cord-010092-uftc8inx 10048 13 but but CC cord-010092-uftc8inx 10048 14 not not RB cord-010092-uftc8inx 10048 15 elsewhere elsewhere RB cord-010092-uftc8inx 10048 16 . . . cord-010092-uftc8inx 10049 1 Summary Summary NNP cord-010092-uftc8inx 10049 2 / / SYM cord-010092-uftc8inx 10049 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 10049 4 : : : cord-010092-uftc8inx 10050 1 Data datum NNS cord-010092-uftc8inx 10050 2 from from IN cord-010092-uftc8inx 10050 3 TGP TGP NNP cord-010092-uftc8inx 10050 4 and and CC cord-010092-uftc8inx 10050 5 gnomAD gnomAD NNP cord-010092-uftc8inx 10050 6 add add VB cord-010092-uftc8inx 10050 7 relevantly relevantly RB cord-010092-uftc8inx 10050 8 to to IN cord-010092-uftc8inx 10050 9 the the DT cord-010092-uftc8inx 10050 10 knowledge knowledge NN cord-010092-uftc8inx 10050 11 on on IN cord-010092-uftc8inx 10050 12 RHD RHD NNP cord-010092-uftc8inx 10050 13 alleles allele NNS cord-010092-uftc8inx 10050 14 ; ; : cord-010092-uftc8inx 10050 15 TGD TGD NNP cord-010092-uftc8inx 10050 16 discloses disclose VBZ cord-010092-uftc8inx 10050 17 linked link VBN cord-010092-uftc8inx 10050 18 intron intron NN cord-010092-uftc8inx 10050 19 polymorphisms polymorphism NNS cord-010092-uftc8inx 10050 20 , , , cord-010092-uftc8inx 10050 21 gnomAD gnomAD NNP cord-010092-uftc8inx 10050 22 frequency frequency NN cord-010092-uftc8inx 10050 23 data datum NNS cord-010092-uftc8inx 10050 24 not not RB cord-010092-uftc8inx 10050 25 biased bias VBN cord-010092-uftc8inx 10050 26 by by IN cord-010092-uftc8inx 10050 27 the the DT cord-010092-uftc8inx 10050 28 likelihood likelihood NN cord-010092-uftc8inx 10050 29 of of IN cord-010092-uftc8inx 10050 30 serologic serologic JJ cord-010092-uftc8inx 10050 31 detection detection NN cord-010092-uftc8inx 10050 32 . . . cord-010092-uftc8inx 10051 1 Current current JJ cord-010092-uftc8inx 10051 2 typing typing NN cord-010092-uftc8inx 10051 3 strategies strategy NNS cord-010092-uftc8inx 10051 4 usually usually RB cord-010092-uftc8inx 10051 5 start start VBP cord-010092-uftc8inx 10051 6 with with IN cord-010092-uftc8inx 10051 7 serology serology NN cord-010092-uftc8inx 10051 8 later later RB cord-010092-uftc8inx 10051 9 complemented complement VBN cord-010092-uftc8inx 10051 10 by by IN cord-010092-uftc8inx 10051 11 molecular molecular JJ cord-010092-uftc8inx 10051 12 typing typing NN cord-010092-uftc8inx 10051 13 . . . cord-010092-uftc8inx 10052 1 In in IN cord-010092-uftc8inx 10052 2 the the DT cord-010092-uftc8inx 10052 3 future future NN cord-010092-uftc8inx 10052 4 , , , cord-010092-uftc8inx 10052 5 molecular molecular JJ cord-010092-uftc8inx 10052 6 methods method NNS cord-010092-uftc8inx 10052 7 will will MD cord-010092-uftc8inx 10052 8 gain gain VB cord-010092-uftc8inx 10052 9 importance importance NN cord-010092-uftc8inx 10052 10 and and CC cord-010092-uftc8inx 10052 11 frequent frequent JJ cord-010092-uftc8inx 10052 12 alleles allele NNS cord-010092-uftc8inx 10052 13 currently currently RB cord-010092-uftc8inx 10052 14 not not RB cord-010092-uftc8inx 10052 15 distinguished distinguish VBN cord-010092-uftc8inx 10052 16 from from IN cord-010092-uftc8inx 10052 17 " " `` cord-010092-uftc8inx 10052 18 standard standard JJ cord-010092-uftc8inx 10052 19 RhD rhd NN cord-010092-uftc8inx 10052 20 " " '' cord-010092-uftc8inx 10052 21 may may MD cord-010092-uftc8inx 10052 22 need need VB cord-010092-uftc8inx 10052 23 a a DT cord-010092-uftc8inx 10052 24 rational rational JJ cord-010092-uftc8inx 10052 25 transfusion transfusion NN cord-010092-uftc8inx 10052 26 strategy strategy NN cord-010092-uftc8inx 10052 27 . . . cord-010092-uftc8inx 10053 1 In in IN cord-010092-uftc8inx 10053 2 this this DT cord-010092-uftc8inx 10053 3 respect respect NN cord-010092-uftc8inx 10053 4 , , , cord-010092-uftc8inx 10053 5 the the DT cord-010092-uftc8inx 10053 6 high high JJ cord-010092-uftc8inx 10053 7 frequency frequency NN cord-010092-uftc8inx 10053 8 of of IN cord-010092-uftc8inx 10053 9 weak weak JJ cord-010092-uftc8inx 10053 10 D d NN cord-010092-uftc8inx 10053 11 type type NN cord-010092-uftc8inx 10053 12 45 45 CD cord-010092-uftc8inx 10053 13 and and CC cord-010092-uftc8inx 10053 14 type type NN cord-010092-uftc8inx 10053 15 33 33 CD cord-010092-uftc8inx 10053 16 in in IN cord-010092-uftc8inx 10053 17 Europeans Europeans NNPS cord-010092-uftc8inx 10053 18 was be VBD cord-010092-uftc8inx 10053 19 surprising surprising JJ cord-010092-uftc8inx 10053 20 , , , cord-010092-uftc8inx 10053 21 might may MD cord-010092-uftc8inx 10053 22 warrant warrant VB cord-010092-uftc8inx 10053 23 confirmation confirmation NN cord-010092-uftc8inx 10053 24 by by IN cord-010092-uftc8inx 10053 25 alternative alternative JJ cord-010092-uftc8inx 10053 26 methods method NNS cord-010092-uftc8inx 10053 27 and and CC cord-010092-uftc8inx 10053 28 should should MD cord-010092-uftc8inx 10053 29 trigger trigger VB cord-010092-uftc8inx 10053 30 discussion discussion NN cord-010092-uftc8inx 10053 31 on on IN cord-010092-uftc8inx 10053 32 rational rational JJ cord-010092-uftc8inx 10053 33 transfusion transfusion NN cord-010092-uftc8inx 10053 34 strategies strategy NNS cord-010092-uftc8inx 10053 35 for for IN cord-010092-uftc8inx 10053 36 these these DT cord-010092-uftc8inx 10053 37 alleles allele NNS cord-010092-uftc8inx 10053 38 . . . cord-010092-uftc8inx 10054 1 consistent consistent JJ cord-010092-uftc8inx 10054 2 with with IN cord-010092-uftc8inx 10054 3 an an DT cord-010092-uftc8inx 10054 4 R r NN cord-010092-uftc8inx 10054 5 0 0 CD cord-010092-uftc8inx 10054 6 haplotype haplotype NN cord-010092-uftc8inx 10054 7 and and CC cord-010092-uftc8inx 10054 8 1 1 CD cord-010092-uftc8inx 10054 9 probable probable JJ cord-010092-uftc8inx 10054 10 Dc- Dc- NNS cord-010092-uftc8inx 10054 11 . . . cord-010092-uftc8inx 10055 1 Two two CD cord-010092-uftc8inx 10055 2 siblings sibling NNS cord-010092-uftc8inx 10055 3 that that WDT cord-010092-uftc8inx 10055 4 were be VBD cord-010092-uftc8inx 10055 5 ABO ABO NNP cord-010092-uftc8inx 10055 6 compatible compatible JJ cord-010092-uftc8inx 10055 7 including include VBG cord-010092-uftc8inx 10055 8 the the DT cord-010092-uftc8inx 10055 9 Dc Dc NNP cord-010092-uftc8inx 10055 10 - - NN cord-010092-uftc8inx 10055 11 sibling sibling NN cord-010092-uftc8inx 10055 12 were be VBD cord-010092-uftc8inx 10055 13 incompatible incompatible JJ cord-010092-uftc8inx 10055 14 at at IN cord-010092-uftc8inx 10055 15 IAT IAT NNP cord-010092-uftc8inx 10055 16 phase phase NN cord-010092-uftc8inx 10055 17 . . . cord-010092-uftc8inx 10056 1 Reactivity reactivity NN cord-010092-uftc8inx 10056 2 could could MD cord-010092-uftc8inx 10056 3 be be VB cord-010092-uftc8inx 10056 4 completely completely RB cord-010092-uftc8inx 10056 5 adsorbed adsorb VBN cord-010092-uftc8inx 10056 6 from from IN cord-010092-uftc8inx 10056 7 the the DT cord-010092-uftc8inx 10056 8 serum serum NN cord-010092-uftc8inx 10056 9 using use VBG cord-010092-uftc8inx 10056 10 R R NNP cord-010092-uftc8inx 10056 11 1 1 CD cord-010092-uftc8inx 10056 12 R r NN cord-010092-uftc8inx 10056 13 1 1 CD cord-010092-uftc8inx 10056 14 , , , cord-010092-uftc8inx 10056 15 R r NN cord-010092-uftc8inx 10056 16 2 2 CD cord-010092-uftc8inx 10056 17 R r NN cord-010092-uftc8inx 10056 18 2 2 CD cord-010092-uftc8inx 10056 19 , , , cord-010092-uftc8inx 10056 20 and and CC cord-010092-uftc8inx 10056 21 rr rr NNP cord-010092-uftc8inx 10056 22 RBCs rbc NNS cord-010092-uftc8inx 10056 23 indicating indicate VBG cord-010092-uftc8inx 10056 24 the the DT cord-010092-uftc8inx 10056 25 antibody antibody NN cord-010092-uftc8inx 10056 26 is be VBZ cord-010092-uftc8inx 10056 27 probably probably RB cord-010092-uftc8inx 10056 28 a a DT cord-010092-uftc8inx 10056 29 single single JJ cord-010092-uftc8inx 10056 30 specificity specificity NN cord-010092-uftc8inx 10056 31 . . . cord-010092-uftc8inx 10057 1 The the DT cord-010092-uftc8inx 10057 2 donor donor NN cord-010092-uftc8inx 10057 3 returned return VBD cord-010092-uftc8inx 10057 4 in in IN cord-010092-uftc8inx 10057 5 2015 2015 CD cord-010092-uftc8inx 10057 6 and and CC cord-010092-uftc8inx 10057 7 2017 2017 CD cord-010092-uftc8inx 10057 8 to to TO cord-010092-uftc8inx 10057 9 continue continue VB cord-010092-uftc8inx 10057 10 autologous autologous JJ cord-010092-uftc8inx 10057 11 donations donation NNS cord-010092-uftc8inx 10057 12 . . . cord-010092-uftc8inx 10058 1 The the DT cord-010092-uftc8inx 10058 2 aim aim NN cord-010092-uftc8inx 10058 3 of of IN cord-010092-uftc8inx 10058 4 this this DT cord-010092-uftc8inx 10058 5 case case NN cord-010092-uftc8inx 10058 6 study study NN cord-010092-uftc8inx 10058 7 was be VBD cord-010092-uftc8inx 10058 8 to to TO cord-010092-uftc8inx 10058 9 examine examine VB cord-010092-uftc8inx 10058 10 the the DT cord-010092-uftc8inx 10058 11 genetic genetic JJ cord-010092-uftc8inx 10058 12 framework framework NN cord-010092-uftc8inx 10058 13 of of IN cord-010092-uftc8inx 10058 14 the the DT cord-010092-uftc8inx 10058 15 RHD RHD NNP cord-010092-uftc8inx 10058 16 and and CC cord-010092-uftc8inx 10058 17 RHCE RHCE NNP cord-010092-uftc8inx 10058 18 genes gene NNS cord-010092-uftc8inx 10058 19 and and CC cord-010092-uftc8inx 10058 20 to to TO cord-010092-uftc8inx 10058 21 characterize characterize VB cord-010092-uftc8inx 10058 22 the the DT cord-010092-uftc8inx 10058 23 Rh Rh NNP cord-010092-uftc8inx 10058 24 epitope epitope NN cord-010092-uftc8inx 10058 25 recognized recognize VBN cord-010092-uftc8inx 10058 26 by by IN cord-010092-uftc8inx 10058 27 the the DT cord-010092-uftc8inx 10058 28 antibody antibody NN cord-010092-uftc8inx 10058 29 . . . cord-010092-uftc8inx 10059 1 Aims aim VBZ cord-010092-uftc8inx 10059 2 : : : cord-010092-uftc8inx 10060 1 The the DT cord-010092-uftc8inx 10060 2 donor donor NN cord-010092-uftc8inx 10060 3 returned return VBD cord-010092-uftc8inx 10060 4 in in IN cord-010092-uftc8inx 10060 5 2015 2015 CD cord-010092-uftc8inx 10060 6 and and CC cord-010092-uftc8inx 10060 7 2017 2017 CD cord-010092-uftc8inx 10060 8 to to TO cord-010092-uftc8inx 10060 9 continue continue VB cord-010092-uftc8inx 10060 10 autologous autologous JJ cord-010092-uftc8inx 10060 11 donations donation NNS cord-010092-uftc8inx 10060 12 . . . cord-010092-uftc8inx 10061 1 The the DT cord-010092-uftc8inx 10061 2 aim aim NN cord-010092-uftc8inx 10061 3 of of IN cord-010092-uftc8inx 10061 4 this this DT cord-010092-uftc8inx 10061 5 case case NN cord-010092-uftc8inx 10061 6 study study NN cord-010092-uftc8inx 10061 7 was be VBD cord-010092-uftc8inx 10061 8 to to TO cord-010092-uftc8inx 10061 9 examine examine VB cord-010092-uftc8inx 10061 10 the the DT cord-010092-uftc8inx 10061 11 genetic genetic JJ cord-010092-uftc8inx 10061 12 framework framework NN cord-010092-uftc8inx 10061 13 of of IN cord-010092-uftc8inx 10061 14 the the DT cord-010092-uftc8inx 10061 15 RHD RHD NNP cord-010092-uftc8inx 10061 16 and and CC cord-010092-uftc8inx 10061 17 RHCE RHCE NNP cord-010092-uftc8inx 10061 18 genes gene NNS cord-010092-uftc8inx 10061 19 and and CC cord-010092-uftc8inx 10061 20 to to TO cord-010092-uftc8inx 10061 21 characterize characterize VB cord-010092-uftc8inx 10061 22 the the DT cord-010092-uftc8inx 10061 23 Rh Rh NNP cord-010092-uftc8inx 10061 24 epitope epitope NN cord-010092-uftc8inx 10061 25 recognized recognize VBN cord-010092-uftc8inx 10061 26 by by IN cord-010092-uftc8inx 10061 27 the the DT cord-010092-uftc8inx 10061 28 antibody antibody NN cord-010092-uftc8inx 10061 29 . . . cord-010092-uftc8inx 10062 1 Methods method NNS cord-010092-uftc8inx 10062 2 : : : cord-010092-uftc8inx 10062 3 Serologic Serologic NNP cord-010092-uftc8inx 10062 4 testing testing NN cord-010092-uftc8inx 10062 5 was be VBD cord-010092-uftc8inx 10062 6 performed perform VBN cord-010092-uftc8inx 10062 7 by by IN cord-010092-uftc8inx 10062 8 manual manual JJ cord-010092-uftc8inx 10062 9 tube tube NN cord-010092-uftc8inx 10062 10 testing testing NN cord-010092-uftc8inx 10062 11 using use VBG cord-010092-uftc8inx 10062 12 AHG AHG NNP cord-010092-uftc8inx 10062 13 in in IN cord-010092-uftc8inx 10062 14 the the DT cord-010092-uftc8inx 10062 15 indirect indirect JJ cord-010092-uftc8inx 10062 16 antiglobulin antiglobulin NN cord-010092-uftc8inx 10062 17 phase phase NN cord-010092-uftc8inx 10062 18 . . . cord-010092-uftc8inx 10063 1 RBC RBC NNP cord-010092-uftc8inx 10063 2 phenotyping phenotyping NN cord-010092-uftc8inx 10063 3 was be VBD cord-010092-uftc8inx 10063 4 performed perform VBN cord-010092-uftc8inx 10063 5 by by IN cord-010092-uftc8inx 10063 6 standard standard JJ cord-010092-uftc8inx 10063 7 tube tube NN cord-010092-uftc8inx 10063 8 hemagglutination hemagglutination NN cord-010092-uftc8inx 10063 9 testing testing NN cord-010092-uftc8inx 10063 10 from from IN cord-010092-uftc8inx 10063 11 EDTA EDTA NNP cord-010092-uftc8inx 10063 12 anticoagulated anticoagulate VBD cord-010092-uftc8inx 10063 13 blood blood NN cord-010092-uftc8inx 10063 14 . . . cord-010092-uftc8inx 10064 1 RHD RHD NNP cord-010092-uftc8inx 10064 2 and and CC cord-010092-uftc8inx 10064 3 RHCE RHCE NNP cord-010092-uftc8inx 10064 4 exons exon NNS cord-010092-uftc8inx 10064 5 were be VBD cord-010092-uftc8inx 10064 6 sequenced sequence VBN cord-010092-uftc8inx 10064 7 using use VBG cord-010092-uftc8inx 10064 8 genomic genomic JJ cord-010092-uftc8inx 10064 9 DNA dna NN cord-010092-uftc8inx 10064 10 and and CC cord-010092-uftc8inx 10064 11 standard standard JJ cord-010092-uftc8inx 10064 12 Sanger Sanger NNP cord-010092-uftc8inx 10064 13 dideoxy dideoxy NN cord-010092-uftc8inx 10064 14 method method NN cord-010092-uftc8inx 10064 15 with with IN cord-010092-uftc8inx 10064 16 the the DT cord-010092-uftc8inx 10064 17 BigDye BigDye NNP cord-010092-uftc8inx 10064 18 Terminator Terminator NNP cord-010092-uftc8inx 10064 19 v3.1 v3.1 NN cord-010092-uftc8inx 10064 20 Cycle Cycle NNP cord-010092-uftc8inx 10064 21 Sequencing Sequencing NNP cord-010092-uftc8inx 10064 22 Kit kit NN cord-010092-uftc8inx 10064 23 . . . cord-010092-uftc8inx 10065 1 Sequence sequence NN cord-010092-uftc8inx 10065 2 data datum NNS cord-010092-uftc8inx 10065 3 was be VBD cord-010092-uftc8inx 10065 4 aligned align VBN cord-010092-uftc8inx 10065 5 to to IN cord-010092-uftc8inx 10065 6 RHD_NG_007494.1 RHD_NG_007494.1 NNP cord-010092-uftc8inx 10065 7 . . . cord-010092-uftc8inx 10066 1 RHD RHD NNP cord-010092-uftc8inx 10066 2 zygosity zygosity NNP cord-010092-uftc8inx 10066 3 was be VBD cord-010092-uftc8inx 10066 4 performed perform VBN cord-010092-uftc8inx 10066 5 using use VBG cord-010092-uftc8inx 10066 6 PCR PCR NNP cord-010092-uftc8inx 10066 7 - - HYPH cord-010092-uftc8inx 10066 8 RFLP RFLP NNP cord-010092-uftc8inx 10066 9 with with IN cord-010092-uftc8inx 10066 10 MspI. MspI. . cord-010092-uftc8inx 10066 11 Background background NN cord-010092-uftc8inx 10066 12 : : : cord-010092-uftc8inx 10067 1 According accord VBG cord-010092-uftc8inx 10067 2 to to IN cord-010092-uftc8inx 10067 3 recent recent JJ cord-010092-uftc8inx 10067 4 findings finding NNS cord-010092-uftc8inx 10067 5 in in IN cord-010092-uftc8inx 10067 6 molecular molecular JJ cord-010092-uftc8inx 10067 7 immuno immuno JJ cord-010092-uftc8inx 10067 8 - - HYPH cord-010092-uftc8inx 10067 9 hematology hematology JJ cord-010092-uftc8inx 10067 10 , , , cord-010092-uftc8inx 10067 11 RHD RHD NNP cord-010092-uftc8inx 10067 12 genotyping genotyping NN cord-010092-uftc8inx 10067 13 is be VBZ cord-010092-uftc8inx 10067 14 strongly strongly RB cord-010092-uftc8inx 10067 15 indicated indicate VBN cord-010092-uftc8inx 10067 16 in in IN cord-010092-uftc8inx 10067 17 RhC+ RhC+ NNP cord-010092-uftc8inx 10067 18 and and CC cord-010092-uftc8inx 10067 19 RhE+ rhe+ JJ cord-010092-uftc8inx 10067 20 donors donor NNS cord-010092-uftc8inx 10067 21 classified classify VBN cord-010092-uftc8inx 10067 22 in in IN cord-010092-uftc8inx 10067 23 routine routine NN cord-010092-uftc8inx 10067 24 as as IN cord-010092-uftc8inx 10067 25 D d NN cord-010092-uftc8inx 10067 26 - - HYPH cord-010092-uftc8inx 10067 27 negative negative JJ cord-010092-uftc8inx 10067 28 . . . cord-010092-uftc8inx 10068 1 Among among IN cord-010092-uftc8inx 10068 2 these these DT cord-010092-uftc8inx 10068 3 , , , cord-010092-uftc8inx 10068 4 one one PRP cord-010092-uftc8inx 10068 5 could could MD cord-010092-uftc8inx 10068 6 find find VB cord-010092-uftc8inx 10068 7 a a DT cord-010092-uftc8inx 10068 8 non non JJ cord-010092-uftc8inx 10068 9 - - JJ cord-010092-uftc8inx 10068 10 negligible negligible JJ cord-010092-uftc8inx 10068 11 share share NN cord-010092-uftc8inx 10068 12 of of IN cord-010092-uftc8inx 10068 13 entirely entirely RB cord-010092-uftc8inx 10068 14 new new JJ cord-010092-uftc8inx 10068 15 genetic genetic JJ cord-010092-uftc8inx 10068 16 alterations alteration NNS cord-010092-uftc8inx 10068 17 or or CC cord-010092-uftc8inx 10068 18 even even RB cord-010092-uftc8inx 10068 19 DEL DEL NNP cord-010092-uftc8inx 10068 20 alleles allele NNS cord-010092-uftc8inx 10068 21 , , , cord-010092-uftc8inx 10068 22 which which WDT cord-010092-uftc8inx 10068 23 are be VBP cord-010092-uftc8inx 10068 24 often often RB cord-010092-uftc8inx 10068 25 not not RB cord-010092-uftc8inx 10068 26 identifiable identifiable JJ cord-010092-uftc8inx 10068 27 with with IN cord-010092-uftc8inx 10068 28 routine routine JJ cord-010092-uftc8inx 10068 29 serological serological JJ cord-010092-uftc8inx 10068 30 methods method NNS cord-010092-uftc8inx 10068 31 due due IN cord-010092-uftc8inx 10068 32 to to IN cord-010092-uftc8inx 10068 33 the the DT cord-010092-uftc8inx 10068 34 low low JJ cord-010092-uftc8inx 10068 35 number number NN cord-010092-uftc8inx 10068 36 of of IN cord-010092-uftc8inx 10068 37 antigenic antigenic JJ cord-010092-uftc8inx 10068 38 sites site NNS cord-010092-uftc8inx 10068 39 . . . cord-010092-uftc8inx 10069 1 Aims aim VBZ cord-010092-uftc8inx 10069 2 : : : cord-010092-uftc8inx 10070 1 The the DT cord-010092-uftc8inx 10070 2 present present JJ cord-010092-uftc8inx 10070 3 study study NN cord-010092-uftc8inx 10070 4 reports report VBZ cord-010092-uftc8inx 10070 5 the the DT cord-010092-uftc8inx 10070 6 genotyping genotyping NN cord-010092-uftc8inx 10070 7 data datum NNS cord-010092-uftc8inx 10070 8 of of IN cord-010092-uftc8inx 10070 9 RHD RHD NNP cord-010092-uftc8inx 10070 10 on on IN cord-010092-uftc8inx 10070 11 201 201 CD cord-010092-uftc8inx 10070 12 RhC+ RhC+ NNP cord-010092-uftc8inx 10070 13 and and CC cord-010092-uftc8inx 10070 14 RhE+ rhe+ JJ cord-010092-uftc8inx 10070 15 Caucasian caucasian JJ cord-010092-uftc8inx 10070 16 donors donor NNS cord-010092-uftc8inx 10070 17 classified classify VBN cord-010092-uftc8inx 10070 18 serologically serologically RB cord-010092-uftc8inx 10070 19 as as IN cord-010092-uftc8inx 10070 20 D d NN cord-010092-uftc8inx 10070 21 - - HYPH cord-010092-uftc8inx 10070 22 negative negative JJ cord-010092-uftc8inx 10070 23 , , , cord-010092-uftc8inx 10070 24 all all DT cord-010092-uftc8inx 10070 25 enrolled enrol VBN cord-010092-uftc8inx 10070 26 by by IN cord-010092-uftc8inx 10070 27 a a DT cord-010092-uftc8inx 10070 28 single single JJ cord-010092-uftc8inx 10070 29 transfusion transfusion NN cord-010092-uftc8inx 10070 30 center center NN cord-010092-uftc8inx 10070 31 in in IN cord-010092-uftc8inx 10070 32 Italy Italy NNP cord-010092-uftc8inx 10070 33 Methods Methods NNPS cord-010092-uftc8inx 10070 34 : : : cord-010092-uftc8inx 10070 35 RhD RhD NNP cord-010092-uftc8inx 10070 36 serological serological JJ cord-010092-uftc8inx 10070 37 typing typing NN cord-010092-uftc8inx 10070 38 was be VBD cord-010092-uftc8inx 10070 39 carried carry VBN cord-010092-uftc8inx 10070 40 out out RP cord-010092-uftc8inx 10070 41 in in IN cord-010092-uftc8inx 10070 42 microplate microplate JJ cord-010092-uftc8inx 10070 43 direct direct JJ cord-010092-uftc8inx 10070 44 agglutination agglutination NN cord-010092-uftc8inx 10070 45 tests test NNS cord-010092-uftc8inx 10070 46 ( ( -LRB- cord-010092-uftc8inx 10070 47 IRIS IRIS NNP cord-010092-uftc8inx 10070 48 , , , cord-010092-uftc8inx 10070 49 Immucor Immucor NNP cord-010092-uftc8inx 10070 50 ) ) -RRB- cord-010092-uftc8inx 10070 51 by by IN cord-010092-uftc8inx 10070 52 using use VBG cord-010092-uftc8inx 10070 53 2 2 CD cord-010092-uftc8inx 10070 54 different different JJ cord-010092-uftc8inx 10070 55 anti anti JJ cord-010092-uftc8inx 10070 56 - - JJ cord-010092-uftc8inx 10070 57 D d JJ cord-010092-uftc8inx 10070 58 IgM IgM NNP cord-010092-uftc8inx 10070 59 clones clone NNS cord-010092-uftc8inx 10071 1 ( ( -LRB- cord-010092-uftc8inx 10071 2 Clone clone NN cord-010092-uftc8inx 10071 3 1 1 CD cord-010092-uftc8inx 10071 4 , , , cord-010092-uftc8inx 10071 5 DVI+ DVI+ NNP cord-010092-uftc8inx 10071 6 : : : cord-010092-uftc8inx 10071 7 LDM1+ESD1 LDM1+ESD1 NNP cord-010092-uftc8inx 10071 8 M M NNP cord-010092-uftc8inx 10071 9 ; ; : cord-010092-uftc8inx 10071 10 Clone clone NN cord-010092-uftc8inx 10071 11 2 2 CD cord-010092-uftc8inx 10071 12 , , , cord-010092-uftc8inx 10071 13 DVI- dvi- NN cord-010092-uftc8inx 10071 14 : : : cord-010092-uftc8inx 10071 15 RUM-1 RUM-1 NNP cord-010092-uftc8inx 10071 16 , , , cord-010092-uftc8inx 10071 17 TH28 TH28 NNP cord-010092-uftc8inx 10071 18 ) ) -RRB- cord-010092-uftc8inx 10071 19 and and CC cord-010092-uftc8inx 10071 20 2 2 CD cord-010092-uftc8inx 10071 21 different different JJ cord-010092-uftc8inx 10071 22 anti anti JJ cord-010092-uftc8inx 10071 23 - - JJ cord-010092-uftc8inx 10071 24 D d JJ cord-010092-uftc8inx 10071 25 IgG igg NN cord-010092-uftc8inx 10071 26 clones clone NNS cord-010092-uftc8inx 10072 1 ( ( -LRB- cord-010092-uftc8inx 10072 2 Clone clone NN cord-010092-uftc8inx 10072 3 1 1 CD cord-010092-uftc8inx 10072 4 : : : cord-010092-uftc8inx 10072 5 MS26 MS26 NNP cord-010092-uftc8inx 10072 6 ; ; : cord-010092-uftc8inx 10072 7 Clone clone NN cord-010092-uftc8inx 10072 8 2 2 CD cord-010092-uftc8inx 10072 9 : : : cord-010092-uftc8inx 10072 10 D415 d415 ADD cord-010092-uftc8inx 10072 11 1E4 1e4 CD cord-010092-uftc8inx 10072 12 ) ) -RRB- cord-010092-uftc8inx 10072 13 . . . cord-010092-uftc8inx 10073 1 All all DT cord-010092-uftc8inx 10073 2 donors donor NNS cord-010092-uftc8inx 10073 3 with with IN cord-010092-uftc8inx 10073 4 D d NN cord-010092-uftc8inx 10073 5 - - HYPH cord-010092-uftc8inx 10073 6 negative negative JJ cord-010092-uftc8inx 10073 7 results result NNS cord-010092-uftc8inx 10074 1 ( ( -LRB- cord-010092-uftc8inx 10074 2 N n NN cord-010092-uftc8inx 10074 3 = = SYM cord-010092-uftc8inx 10074 4 201 201 CD cord-010092-uftc8inx 10074 5 , , , cord-010092-uftc8inx 10074 6 divided divide VBN cord-010092-uftc8inx 10074 7 into into IN cord-010092-uftc8inx 10074 8 153 153 CD cord-010092-uftc8inx 10074 9 subjects subject NNS cord-010092-uftc8inx 10074 10 with with IN cord-010092-uftc8inx 10074 11 RhC+ RhC+ NNP cord-010092-uftc8inx 10074 12 , , , cord-010092-uftc8inx 10074 13 45 45 CD cord-010092-uftc8inx 10074 14 with with IN cord-010092-uftc8inx 10074 15 RhE+ RhE+ NNP cord-010092-uftc8inx 10074 16 and and CC cord-010092-uftc8inx 10074 17 3 3 CD cord-010092-uftc8inx 10074 18 with with IN cord-010092-uftc8inx 10074 19 both both DT cord-010092-uftc8inx 10074 20 RHC+ RHC+ NNP cord-010092-uftc8inx 10074 21 and and CC cord-010092-uftc8inx 10074 22 RhE+ RhE+ NNP cord-010092-uftc8inx 10074 23 ) ) -RRB- cord-010092-uftc8inx 10074 24 were be VBD cord-010092-uftc8inx 10074 25 addressed address VBN cord-010092-uftc8inx 10074 26 to to IN cord-010092-uftc8inx 10074 27 genotype genotype NN cord-010092-uftc8inx 10074 28 analysis analysis NN cord-010092-uftc8inx 10074 29 with with IN cord-010092-uftc8inx 10074 30 RHD RHD NNP cord-010092-uftc8inx 10074 31 BeadChip BeadChip NNP cord-010092-uftc8inx 10074 32 Molecular Molecular NNP cord-010092-uftc8inx 10074 33 Test Test NNP cord-010092-uftc8inx 10074 34 ( ( -LRB- cord-010092-uftc8inx 10074 35 Immucor Immucor NNP cord-010092-uftc8inx 10074 36 ) ) -RRB- cord-010092-uftc8inx 10074 37 , , , cord-010092-uftc8inx 10074 38 PCR PCR NNP cord-010092-uftc8inx 10074 39 - - HYPH cord-010092-uftc8inx 10074 40 SSP SSP NNP cord-010092-uftc8inx 10075 1 ( ( -LRB- cord-010092-uftc8inx 10075 2 BAGene BAGene NNP cord-010092-uftc8inx 10075 3 , , , cord-010092-uftc8inx 10075 4 Inno Inno NNP cord-010092-uftc8inx 10075 5 - - HYPH cord-010092-uftc8inx 10075 6 Train Train NNP cord-010092-uftc8inx 10075 7 ) ) -RRB- cord-010092-uftc8inx 10075 8 and/or and/or CC cord-010092-uftc8inx 10076 1 RBC RBC NNP cord-010092-uftc8inx 10076 2 - - HYPH cord-010092-uftc8inx 10076 3 FluoGene FluoGene NNP cord-010092-uftc8inx 10077 1 ( ( -LRB- cord-010092-uftc8inx 10077 2 Inno Inno NNP cord-010092-uftc8inx 10077 3 - - HYPH cord-010092-uftc8inx 10077 4 Train Train NNP cord-010092-uftc8inx 10077 5 ) ) -RRB- cord-010092-uftc8inx 10077 6 . . . cord-010092-uftc8inx 10078 1 The the DT cord-010092-uftc8inx 10078 2 discrepant discrepant JJ cord-010092-uftc8inx 10078 3 results result NNS cord-010092-uftc8inx 10078 4 between between IN cord-010092-uftc8inx 10078 5 serology serology NN cord-010092-uftc8inx 10078 6 ( ( -LRB- cord-010092-uftc8inx 10078 7 D d NN cord-010092-uftc8inx 10078 8 - - HYPH cord-010092-uftc8inx 10078 9 neg neg JJ cord-010092-uftc8inx 10078 10 ) ) -RRB- cord-010092-uftc8inx 10078 11 and and CC cord-010092-uftc8inx 10078 12 molecular molecular JJ cord-010092-uftc8inx 10078 13 biology biology NN cord-010092-uftc8inx 10079 1 ( ( -LRB- cord-010092-uftc8inx 10079 2 wild wild JJ cord-010092-uftc8inx 10079 3 - - HYPH cord-010092-uftc8inx 10079 4 type type NN cord-010092-uftc8inx 10079 5 or or CC cord-010092-uftc8inx 10079 6 full full JJ cord-010092-uftc8inx 10079 7 - - HYPH cord-010092-uftc8inx 10079 8 length length NN cord-010092-uftc8inx 10079 9 RHD RHD NNP cord-010092-uftc8inx 10079 10 gene gene NN cord-010092-uftc8inx 10079 11 ) ) -RRB- cord-010092-uftc8inx 10079 12 were be VBD cord-010092-uftc8inx 10079 13 further further RB cord-010092-uftc8inx 10079 14 investigated investigate VBN cord-010092-uftc8inx 10079 15 by by IN cord-010092-uftc8inx 10079 16 bi bi JJ cord-010092-uftc8inx 10079 17 - - JJ cord-010092-uftc8inx 10079 18 directional directional JJ cord-010092-uftc8inx 10079 19 sequencing sequencing NN cord-010092-uftc8inx 10079 20 of of IN cord-010092-uftc8inx 10079 21 the the DT cord-010092-uftc8inx 10079 22 RHD RHD NNP cord-010092-uftc8inx 10079 23 coding coding NN cord-010092-uftc8inx 10079 24 regions region NNS cord-010092-uftc8inx 10079 25 . . . cord-010092-uftc8inx 10080 1 Results result NNS cord-010092-uftc8inx 10080 2 : : : cord-010092-uftc8inx 10081 1 One one CD cord-010092-uftc8inx 10081 2 - - HYPH cord-010092-uftc8inx 10081 3 hundred hundred CD cord-010092-uftc8inx 10081 4 donors donor NNS cord-010092-uftc8inx 10081 5 have have VBP cord-010092-uftc8inx 10081 6 been be VBN cord-010092-uftc8inx 10081 7 analyzed analyze VBN cord-010092-uftc8inx 10081 8 retrospectively retrospectively RB cord-010092-uftc8inx 10081 9 , , , cord-010092-uftc8inx 10081 10 as as IN cord-010092-uftc8inx 10081 11 part part NN cord-010092-uftc8inx 10081 12 of of IN cord-010092-uftc8inx 10081 13 a a DT cord-010092-uftc8inx 10081 14 pilot pilot NN cord-010092-uftc8inx 10081 15 study study NN cord-010092-uftc8inx 10081 16 . . . cord-010092-uftc8inx 10082 1 Following follow VBG cord-010092-uftc8inx 10082 2 the the DT cord-010092-uftc8inx 10082 3 data datum NNS cord-010092-uftc8inx 10082 4 obtained obtain VBN cord-010092-uftc8inx 10082 5 in in IN cord-010092-uftc8inx 10082 6 this this DT cord-010092-uftc8inx 10082 7 first first JJ cord-010092-uftc8inx 10082 8 phase phase NN cord-010092-uftc8inx 10082 9 , , , cord-010092-uftc8inx 10082 10 the the DT cord-010092-uftc8inx 10082 11 analysis analysis NN cord-010092-uftc8inx 10082 12 methods method NNS cord-010092-uftc8inx 10082 13 described describe VBN cord-010092-uftc8inx 10082 14 above above RB cord-010092-uftc8inx 10082 15 have have VBP cord-010092-uftc8inx 10082 16 been be VBN cord-010092-uftc8inx 10082 17 implemented implement VBN cord-010092-uftc8inx 10082 18 in in IN cord-010092-uftc8inx 10082 19 routine routine NN cord-010092-uftc8inx 10082 20 , , , cord-010092-uftc8inx 10082 21 allowing allow VBG cord-010092-uftc8inx 10082 22 to to TO cord-010092-uftc8inx 10082 23 include include VB cord-010092-uftc8inx 10082 24 further further RB cord-010092-uftc8inx 10082 25 101 101 CD cord-010092-uftc8inx 10082 26 donors donor NNS cord-010092-uftc8inx 10082 27 , , , cord-010092-uftc8inx 10082 28 studied study VBD cord-010092-uftc8inx 10082 29 prospectively prospectively RB cord-010092-uftc8inx 10082 30 . . . cord-010092-uftc8inx 10083 1 In in IN cord-010092-uftc8inx 10083 2 92.5 92.5 CD cord-010092-uftc8inx 10083 3 % % NN cord-010092-uftc8inx 10083 4 of of IN cord-010092-uftc8inx 10083 5 donors donor NNS cord-010092-uftc8inx 10083 6 ( ( -LRB- cord-010092-uftc8inx 10083 7 N n NN cord-010092-uftc8inx 10083 8 = = SYM cord-010092-uftc8inx 10083 9 186 186 CD cord-010092-uftc8inx 10083 10 ) ) -RRB- cord-010092-uftc8inx 10083 11 , , , cord-010092-uftc8inx 10083 12 the the DT cord-010092-uftc8inx 10083 13 molecular molecular JJ cord-010092-uftc8inx 10083 14 analyses analysis NNS cord-010092-uftc8inx 10083 15 showed show VBD cord-010092-uftc8inx 10083 16 the the DT cord-010092-uftc8inx 10083 17 complete complete JJ cord-010092-uftc8inx 10083 18 deletion deletion NN cord-010092-uftc8inx 10083 19 of of IN cord-010092-uftc8inx 10083 20 the the DT cord-010092-uftc8inx 10083 21 RHD RHD NNP cord-010092-uftc8inx 10083 22 locus locus NN cord-010092-uftc8inx 10083 23 , , , cord-010092-uftc8inx 10083 24 while while IN cord-010092-uftc8inx 10083 25 in in IN cord-010092-uftc8inx 10083 26 15 15 CD cord-010092-uftc8inx 10083 27 cases case NNS cord-010092-uftc8inx 10083 28 ( ( -LRB- cord-010092-uftc8inx 10083 29 7.5 7.5 CD cord-010092-uftc8inx 10083 30 % % NN cord-010092-uftc8inx 10083 31 ) ) -RRB- cord-010092-uftc8inx 10083 32 a a DT cord-010092-uftc8inx 10083 33 genetic genetic JJ cord-010092-uftc8inx 10083 34 status status NN cord-010092-uftc8inx 10083 35 was be VBD cord-010092-uftc8inx 10083 36 found find VBN cord-010092-uftc8inx 10083 37 with with IN cord-010092-uftc8inx 10083 38 " " `` cord-010092-uftc8inx 10083 39 non non JJ cord-010092-uftc8inx 10083 40 - - JJ cord-010092-uftc8inx 10083 41 deleted deleted JJ cord-010092-uftc8inx 10083 42 " " `` cord-010092-uftc8inx 10083 43 RHD RHD NNP cord-010092-uftc8inx 10083 44 . . . cord-010092-uftc8inx 10084 1 Over over IN cord-010092-uftc8inx 10084 2 all all DT cord-010092-uftc8inx 10084 3 , , , cord-010092-uftc8inx 10084 4 bi bi JJ cord-010092-uftc8inx 10084 5 - - JJ cord-010092-uftc8inx 10084 6 directional directional JJ cord-010092-uftc8inx 10084 7 sequencing sequencing NN cord-010092-uftc8inx 10084 8 on on IN cord-010092-uftc8inx 10084 9 these these DT cord-010092-uftc8inx 10084 10 15 15 CD cord-010092-uftc8inx 10084 11 donors donor NNS cord-010092-uftc8inx 10084 12 revealed reveal VBD cord-010092-uftc8inx 10084 13 the the DT cord-010092-uftc8inx 10084 14 presence presence NN cord-010092-uftc8inx 10084 15 of of IN cord-010092-uftc8inx 10084 16 9 9 CD cord-010092-uftc8inx 10084 17 negative negative JJ cord-010092-uftc8inx 10084 18 and and CC cord-010092-uftc8inx 10084 19 4 4 CD cord-010092-uftc8inx 10084 20 Weak weak JJ cord-010092-uftc8inx 10084 21 - - HYPH cord-010092-uftc8inx 10084 22 D d JJ cord-010092-uftc8inx 10084 23 variants variant NNS cord-010092-uftc8inx 10084 24 . . . cord-010092-uftc8inx 10085 1 The the DT cord-010092-uftc8inx 10085 2 list list NN cord-010092-uftc8inx 10085 3 of of IN cord-010092-uftc8inx 10085 4 RHD RHD NNP cord-010092-uftc8inx 10085 5 alleles allele NNS cord-010092-uftc8inx 10085 6 we -PRON- PRP cord-010092-uftc8inx 10085 7 have have VBP cord-010092-uftc8inx 10085 8 identified identify VBN cord-010092-uftc8inx 10085 9 at at IN cord-010092-uftc8inx 10085 10 the the DT cord-010092-uftc8inx 10085 11 molecular molecular JJ cord-010092-uftc8inx 10085 12 level level NN cord-010092-uftc8inx 10085 13 is be VBZ cord-010092-uftc8inx 10085 14 as as IN cord-010092-uftc8inx 10085 15 follows follow VBZ cord-010092-uftc8inx 10085 16 : : : cord-010092-uftc8inx 10085 17 RHD*01N.82 RHD*01N.82 NNP cord-010092-uftc8inx 10085 18 ( ( -LRB- cord-010092-uftc8inx 10085 19 2 2 CD cord-010092-uftc8inx 10085 20 cases case NNS cord-010092-uftc8inx 10085 21 ) ) -RRB- cord-010092-uftc8inx 10085 22 , , , cord-010092-uftc8inx 10085 23 RHD*01N.83 RHD*01N.83 NNPS cord-010092-uftc8inx 10085 24 ( ( -LRB- cord-010092-uftc8inx 10085 25 1 1 CD cord-010092-uftc8inx 10085 26 ) ) -RRB- cord-010092-uftc8inx 10085 27 , , , cord-010092-uftc8inx 10085 28 RHD*01N.80 RHD*01N.80 NNP cord-010092-uftc8inx 10085 29 ( ( -LRB- cord-010092-uftc8inx 10085 30 1 1 CD cord-010092-uftc8inx 10085 31 ) ) -RRB- cord-010092-uftc8inx 10085 32 , , , cord-010092-uftc8inx 10085 33 RHD*01N.61 RHD*01N.61 NNPS cord-010092-uftc8inx 10085 34 ( ( -LRB- cord-010092-uftc8inx 10085 35 1 1 CD cord-010092-uftc8inx 10085 36 ) ) -RRB- cord-010092-uftc8inx 10085 37 , , , cord-010092-uftc8inx 10085 38 RHD*01N.05 RHD*01N.05 NNP cord-010092-uftc8inx 10085 39 ( ( -LRB- cord-010092-uftc8inx 10085 40 3 3 CD cord-010092-uftc8inx 10085 41 ) ) -RRB- cord-010092-uftc8inx 10085 42 , , , cord-010092-uftc8inx 10085 43 RHD*01EL.08 rhd*01el.08 NN cord-010092-uftc8inx 10085 44 ( ( -LRB- cord-010092-uftc8inx 10085 45 1 1 CD cord-010092-uftc8inx 10085 46 ) ) -RRB- cord-010092-uftc8inx 10085 47 , , . cord-010092-uftc8inx 10086 1 RHD*01EL.18 rhd*01el.18 LS cord-010092-uftc8inx 10086 2 ( ( -LRB- cord-010092-uftc8inx 10086 3 1 1 CD cord-010092-uftc8inx 10086 4 ) ) -RRB- cord-010092-uftc8inx 10086 5 , , . cord-010092-uftc8inx 10087 1 RHD*01EL.17 RHD*01EL.17 NNP cord-010092-uftc8inx 10087 2 ( ( -LRB- cord-010092-uftc8inx 10087 3 1 1 CD cord-010092-uftc8inx 10087 4 ) ) -RRB- cord-010092-uftc8inx 10087 5 , , , cord-010092-uftc8inx 10087 6 RHD*01W.54 RHD*01W.54 NNP cord-010092-uftc8inx 10087 7 ( ( -LRB- cord-010092-uftc8inx 10087 8 1 1 CD cord-010092-uftc8inx 10087 9 ) ) -RRB- cord-010092-uftc8inx 10087 10 . . . cord-010092-uftc8inx 10088 1 Moreover moreover RB cord-010092-uftc8inx 10088 2 we -PRON- PRP cord-010092-uftc8inx 10088 3 found find VBD cord-010092-uftc8inx 10088 4 a a DT cord-010092-uftc8inx 10088 5 donor donor NN cord-010092-uftc8inx 10088 6 with with IN cord-010092-uftc8inx 10088 7 a a DT cord-010092-uftc8inx 10088 8 lack lack NN cord-010092-uftc8inx 10088 9 of of IN cord-010092-uftc8inx 10088 10 signal signal NN cord-010092-uftc8inx 10088 11 encompassing encompass VBG cord-010092-uftc8inx 10088 12 exons exon NNS cord-010092-uftc8inx 10088 13 1 1 CD cord-010092-uftc8inx 10088 14 - - SYM cord-010092-uftc8inx 10088 15 5 5 CD cord-010092-uftc8inx 10088 16 of of IN cord-010092-uftc8inx 10088 17 the the DT cord-010092-uftc8inx 10088 18 RHD RHD NNP cord-010092-uftc8inx 10088 19 sequence sequence NN cord-010092-uftc8inx 10088 20 ( ( -LRB- cord-010092-uftc8inx 10088 21 BioArray BioArray NNP cord-010092-uftc8inx 10088 22 RHD RHD NNP cord-010092-uftc8inx 10088 23 BeadChip BeadChip NNP cord-010092-uftc8inx 10088 24 ) ) -RRB- cord-010092-uftc8inx 10088 25 , , , cord-010092-uftc8inx 10088 26 while while IN cord-010092-uftc8inx 10088 27 2 2 CD cord-010092-uftc8inx 10088 28 additional additional JJ cord-010092-uftc8inx 10088 29 cases case NNS cord-010092-uftc8inx 10088 30 are be VBP cord-010092-uftc8inx 10088 31 currently currently RB cord-010092-uftc8inx 10088 32 under under IN cord-010092-uftc8inx 10088 33 investigation investigation NN cord-010092-uftc8inx 10088 34 . . . cord-010092-uftc8inx 10089 1 Summary Summary NNP cord-010092-uftc8inx 10089 2 / / SYM cord-010092-uftc8inx 10089 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 10089 4 : : : cord-010092-uftc8inx 10090 1 Our -PRON- PRP$ cord-010092-uftc8inx 10090 2 study study NN cord-010092-uftc8inx 10090 3 confirms confirm VBZ cord-010092-uftc8inx 10090 4 that that IN cord-010092-uftc8inx 10090 5 a a DT cord-010092-uftc8inx 10090 6 non non JJ cord-010092-uftc8inx 10090 7 - - JJ cord-010092-uftc8inx 10090 8 negligible negligible JJ cord-010092-uftc8inx 10090 9 number number NN cord-010092-uftc8inx 10090 10 of of IN cord-010092-uftc8inx 10090 11 Caucasian caucasian JJ cord-010092-uftc8inx 10090 12 subjects subject NNS cord-010092-uftc8inx 10090 13 , , , cord-010092-uftc8inx 10090 14 classified classify VBN cord-010092-uftc8inx 10090 15 serologically serologically RB cord-010092-uftc8inx 10090 16 as as IN cord-010092-uftc8inx 10090 17 D d NN cord-010092-uftc8inx 10090 18 - - HYPH cord-010092-uftc8inx 10090 19 negative negative JJ cord-010092-uftc8inx 10090 20 , , , cord-010092-uftc8inx 10090 21 present present JJ cord-010092-uftc8inx 10090 22 RHD RHD NNP cord-010092-uftc8inx 10090 23 gene gene NN cord-010092-uftc8inx 10090 24 alterations alteration NNS cord-010092-uftc8inx 10090 25 that that WDT cord-010092-uftc8inx 10090 26 differ differ VBP cord-010092-uftc8inx 10090 27 from from IN cord-010092-uftc8inx 10090 28 the the DT cord-010092-uftc8inx 10090 29 common common JJ cord-010092-uftc8inx 10090 30 total total JJ cord-010092-uftc8inx 10090 31 deletion deletion NN cord-010092-uftc8inx 10090 32 . . . cord-010092-uftc8inx 10091 1 In in IN cord-010092-uftc8inx 10091 2 line line NN cord-010092-uftc8inx 10091 3 with with IN cord-010092-uftc8inx 10091 4 the the DT cord-010092-uftc8inx 10091 5 literature literature NN cord-010092-uftc8inx 10091 6 data datum NNS cord-010092-uftc8inx 10091 7 , , , cord-010092-uftc8inx 10091 8 we -PRON- PRP cord-010092-uftc8inx 10091 9 also also RB cord-010092-uftc8inx 10091 10 found find VBD cord-010092-uftc8inx 10091 11 a a DT cord-010092-uftc8inx 10091 12 frequency frequency NN cord-010092-uftc8inx 10091 13 of of IN cord-010092-uftc8inx 10091 14 about about IN cord-010092-uftc8inx 10091 15 1 1 CD cord-010092-uftc8inx 10091 16 in in IN cord-010092-uftc8inx 10091 17 50 50 CD cord-010092-uftc8inx 10091 18 cases case NNS cord-010092-uftc8inx 10091 19 ( ( -LRB- cord-010092-uftc8inx 10091 20 4 4 CD cord-010092-uftc8inx 10091 21 subjects subject NNS cord-010092-uftc8inx 10091 22 out out IN cord-010092-uftc8inx 10091 23 of of IN cord-010092-uftc8inx 10091 24 201 201 CD cord-010092-uftc8inx 10091 25 ) ) -RRB- cord-010092-uftc8inx 10091 26 , , , cord-010092-uftc8inx 10091 27 in in IN cord-010092-uftc8inx 10091 28 which which WDT cord-010092-uftc8inx 10091 29 a a DT cord-010092-uftc8inx 10091 30 donor donor NN cord-010092-uftc8inx 10091 31 re re NN cord-010092-uftc8inx 10091 32 - - NN cord-010092-uftc8inx 10091 33 classification classification NN cord-010092-uftc8inx 10091 34 as as IN cord-010092-uftc8inx 10091 35 D d NN cord-010092-uftc8inx 10091 36 - - HYPH cord-010092-uftc8inx 10091 37 positive positive JJ cord-010092-uftc8inx 10091 38 ( ( -LRB- cord-010092-uftc8inx 10091 39 weak weak JJ cord-010092-uftc8inx 10091 40 D d NN cord-010092-uftc8inx 10091 41 type type NN cord-010092-uftc8inx 10091 42 ) ) -RRB- cord-010092-uftc8inx 10091 43 was be VBD cord-010092-uftc8inx 10091 44 necessary necessary JJ cord-010092-uftc8inx 10091 45 . . . cord-010092-uftc8inx 10092 1 Hence hence RB cord-010092-uftc8inx 10092 2 , , , cord-010092-uftc8inx 10092 3 a a DT cord-010092-uftc8inx 10092 4 wider wide JJR cord-010092-uftc8inx 10092 5 use use NN cord-010092-uftc8inx 10092 6 of of IN cord-010092-uftc8inx 10092 7 molecular molecular JJ cord-010092-uftc8inx 10092 8 typing typing NN cord-010092-uftc8inx 10092 9 methods method NNS cord-010092-uftc8inx 10092 10 is be VBZ cord-010092-uftc8inx 10092 11 desirable desirable JJ cord-010092-uftc8inx 10092 12 in in IN cord-010092-uftc8inx 10092 13 order order NN cord-010092-uftc8inx 10092 14 to to TO cord-010092-uftc8inx 10092 15 achieve achieve VB cord-010092-uftc8inx 10092 16 the the DT cord-010092-uftc8inx 10092 17 correct correct JJ cord-010092-uftc8inx 10092 18 genetic genetic JJ cord-010092-uftc8inx 10092 19 characterization characterization NN cord-010092-uftc8inx 10092 20 and and CC cord-010092-uftc8inx 10092 21 the the DT cord-010092-uftc8inx 10092 22 appropriate appropriate JJ cord-010092-uftc8inx 10092 23 phenotypic phenotypic JJ cord-010092-uftc8inx 10092 24 classification classification NN cord-010092-uftc8inx 10092 25 of of IN cord-010092-uftc8inx 10092 26 " " `` cord-010092-uftc8inx 10092 27 apparently apparently RB cord-010092-uftc8inx 10092 28 " " `` cord-010092-uftc8inx 10092 29 D d JJ cord-010092-uftc8inx 10092 30 - - HYPH cord-010092-uftc8inx 10092 31 negative negative JJ cord-010092-uftc8inx 10092 32 donors donor NNS cord-010092-uftc8inx 10092 33 . . . cord-010092-uftc8inx 10093 1 Background background NN cord-010092-uftc8inx 10093 2 : : : cord-010092-uftc8inx 10094 1 Without without IN cord-010092-uftc8inx 10094 2 evidence evidence NN cord-010092-uftc8inx 10094 3 of of IN cord-010092-uftc8inx 10094 4 abnormal abnormal JJ cord-010092-uftc8inx 10094 5 serological serological JJ cord-010092-uftc8inx 10094 6 D d NN cord-010092-uftc8inx 10094 7 antigen antigen NN cord-010092-uftc8inx 10094 8 expression expression NN cord-010092-uftc8inx 10094 9 there there EX cord-010092-uftc8inx 10094 10 will will MD cord-010092-uftc8inx 10094 11 be be VB cord-010092-uftc8inx 10094 12 no no DT cord-010092-uftc8inx 10094 13 quest quest NN cord-010092-uftc8inx 10094 14 for for IN cord-010092-uftc8inx 10094 15 weak weak JJ cord-010092-uftc8inx 10094 16 D D NNP cord-010092-uftc8inx 10094 17 , , , cord-010092-uftc8inx 10094 18 partial partial JJ cord-010092-uftc8inx 10094 19 D d NN cord-010092-uftc8inx 10094 20 or or CC cord-010092-uftc8inx 10094 21 D d NN cord-010092-uftc8inx 10094 22 variant variant NN cord-010092-uftc8inx 10094 23 on on IN cord-010092-uftc8inx 10094 24 the the DT cord-010092-uftc8inx 10094 25 red red JJ cord-010092-uftc8inx 10094 26 blood blood NN cord-010092-uftc8inx 10094 27 cells cell NNS cord-010092-uftc8inx 10094 28 . . . cord-010092-uftc8inx 10095 1 According accord VBG cord-010092-uftc8inx 10095 2 to to IN cord-010092-uftc8inx 10095 3 our -PRON- PRP$ cord-010092-uftc8inx 10095 4 blood blood NN cord-010092-uftc8inx 10095 5 donor donor NN cord-010092-uftc8inx 10095 6 registry registry NN cord-010092-uftc8inx 10095 7 we -PRON- PRP cord-010092-uftc8inx 10095 8 found find VBD cord-010092-uftc8inx 10095 9 that that IN cord-010092-uftc8inx 10095 10 out out IN cord-010092-uftc8inx 10095 11 of of IN cord-010092-uftc8inx 10095 12 43960 43960 CD cord-010092-uftc8inx 10095 13 serologically serologically RB cord-010092-uftc8inx 10095 14 typed type VBN cord-010092-uftc8inx 10095 15 donors donor NNS cord-010092-uftc8inx 10095 16 , , , cord-010092-uftc8inx 10095 17 85.5 85.5 CD cord-010092-uftc8inx 10095 18 % % NN cord-010092-uftc8inx 10095 19 were be VBD cord-010092-uftc8inx 10095 20 D+ D+ NNS cord-010092-uftc8inx 10095 21 , , , cord-010092-uftc8inx 10095 22 14.0 14.0 CD cord-010092-uftc8inx 10095 23 % % NN cord-010092-uftc8inx 10095 24 D d NN cord-010092-uftc8inx 10095 25 - - : cord-010092-uftc8inx 10095 26 and and CC cord-010092-uftc8inx 10095 27 0.5 0.5 CD cord-010092-uftc8inx 10095 28 % % NN cord-010092-uftc8inx 10095 29 weak weak JJ cord-010092-uftc8inx 10095 30 D. D. NNP cord-010092-uftc8inx 10095 31 Aims Aims NNP cord-010092-uftc8inx 10095 32 : : : cord-010092-uftc8inx 10095 33 To to TO cord-010092-uftc8inx 10095 34 compare compare VB cord-010092-uftc8inx 10095 35 different different JJ cord-010092-uftc8inx 10095 36 weak weak JJ cord-010092-uftc8inx 10095 37 serological serological JJ cord-010092-uftc8inx 10095 38 reactions reaction NNS cord-010092-uftc8inx 10095 39 of of IN cord-010092-uftc8inx 10095 40 the the DT cord-010092-uftc8inx 10095 41 D d NN cord-010092-uftc8inx 10095 42 antigen antigen NN cord-010092-uftc8inx 10095 43 to to IN cord-010092-uftc8inx 10095 44 the the DT cord-010092-uftc8inx 10095 45 RHD RHD NNP cord-010092-uftc8inx 10095 46 genotyping genotyping NN cord-010092-uftc8inx 10095 47 . . . cord-010092-uftc8inx 10096 1 Methods method NNS cord-010092-uftc8inx 10096 2 : : : cord-010092-uftc8inx 10097 1 Molecular molecular JJ cord-010092-uftc8inx 10097 2 RHD RHD NNP cord-010092-uftc8inx 10097 3 typing type VBG cord-010092-uftc8inx 10097 4 using use VBG cord-010092-uftc8inx 10097 5 isolated isolate VBN cord-010092-uftc8inx 10097 6 DNA DNA NNP cord-010092-uftc8inx 10097 7 and and CC cord-010092-uftc8inx 10097 8 RBC RBC NNP cord-010092-uftc8inx 10097 9 - - HYPH cord-010092-uftc8inx 10097 10 Ready Ready NNP cord-010092-uftc8inx 10097 11 Gene Gene NNP cord-010092-uftc8inx 10097 12 CDE CDE NNP cord-010092-uftc8inx 10097 13 and and CC cord-010092-uftc8inx 10097 14 RBC RBC NNP cord-010092-uftc8inx 10097 15 - - HYPH cord-010092-uftc8inx 10097 16 Ready Ready NNP cord-010092-uftc8inx 10098 1 Gene gene NN cord-010092-uftc8inx 10098 2 D D NNP cord-010092-uftc8inx 10098 3 weak weak JJ cord-010092-uftc8inx 10098 4 kits kit NNS cord-010092-uftc8inx 10098 5 was be VBD cord-010092-uftc8inx 10098 6 performed perform VBN cord-010092-uftc8inx 10098 7 in in IN cord-010092-uftc8inx 10098 8 22 22 CD cord-010092-uftc8inx 10098 9 blood blood NN cord-010092-uftc8inx 10098 10 donors donor NNS cord-010092-uftc8inx 10098 11 , , , cord-010092-uftc8inx 10098 12 who who WP cord-010092-uftc8inx 10098 13 were be VBD cord-010092-uftc8inx 10098 14 serologically serologically RB cord-010092-uftc8inx 10098 15 typed type VBN cord-010092-uftc8inx 10098 16 as as IN cord-010092-uftc8inx 10098 17 weak weak JJ cord-010092-uftc8inx 10098 18 D d NN cord-010092-uftc8inx 10098 19 using use VBG cord-010092-uftc8inx 10098 20 monoclonal monoclonal JJ cord-010092-uftc8inx 10098 21 blended blended NNP cord-010092-uftc8inx 10098 22 IgM IgM NNP cord-010092-uftc8inx 10098 23 / / SYM cord-010092-uftc8inx 10098 24 IgG IgG NNP cord-010092-uftc8inx 10098 25 and and CC cord-010092-uftc8inx 10098 26 DVI DVI NNP cord-010092-uftc8inx 10098 27 - - : cord-010092-uftc8inx 10098 28 and and CC cord-010092-uftc8inx 10098 29 DVI+ DVI+ NNP cord-010092-uftc8inx 10098 30 anti anti JJ cord-010092-uftc8inx 10098 31 - - JJ cord-010092-uftc8inx 10098 32 D d JJ cord-010092-uftc8inx 10098 33 reagents reagent NNS cord-010092-uftc8inx 10098 34 by by IN cord-010092-uftc8inx 10098 35 slide slide NN cord-010092-uftc8inx 10098 36 and and CC cord-010092-uftc8inx 10098 37 microplate microplate NN cord-010092-uftc8inx 10098 38 ( ( -LRB- cord-010092-uftc8inx 10098 39 MP MP NNP cord-010092-uftc8inx 10098 40 ) ) -RRB- cord-010092-uftc8inx 10098 41 technique technique NN cord-010092-uftc8inx 10098 42 respectfully respectfully RB cord-010092-uftc8inx 10098 43 , , , cord-010092-uftc8inx 10098 44 as as RB cord-010092-uftc8inx 10098 45 well well RB cord-010092-uftc8inx 10098 46 as as IN cord-010092-uftc8inx 10098 47 by by IN cord-010092-uftc8inx 10098 48 the the DT cord-010092-uftc8inx 10098 49 antiglobulin antiglobulin NN cord-010092-uftc8inx 10098 50 test test NN cord-010092-uftc8inx 10098 51 ( ( -LRB- cord-010092-uftc8inx 10098 52 IAT IAT NNP cord-010092-uftc8inx 10098 53 ) ) -RRB- cord-010092-uftc8inx 10098 54 in in IN cord-010092-uftc8inx 10098 55 gel gel NN cord-010092-uftc8inx 10098 56 and and CC cord-010092-uftc8inx 10098 57 with with IN cord-010092-uftc8inx 10098 58 the the DT cord-010092-uftc8inx 10098 59 set set NN cord-010092-uftc8inx 10098 60 of of IN cord-010092-uftc8inx 10098 61 monoclonal monoclonal JJ cord-010092-uftc8inx 10098 62 partial partial JJ cord-010092-uftc8inx 10098 63 D d NN cord-010092-uftc8inx 10098 64 typing typing NN cord-010092-uftc8inx 10098 65 reagents reagent NNS cord-010092-uftc8inx 10098 66 ( ( -LRB- cord-010092-uftc8inx 10098 67 BioRad BioRad NNP cord-010092-uftc8inx 10098 68 ) ) -RRB- cord-010092-uftc8inx 10098 69 . . . cord-010092-uftc8inx 10099 1 In in IN cord-010092-uftc8inx 10099 2 addition addition NN cord-010092-uftc8inx 10099 3 , , , cord-010092-uftc8inx 10099 4 RhCcEe RhCcEe NNP cord-010092-uftc8inx 10099 5 phenotyping phenotyping NN cord-010092-uftc8inx 10099 6 and and CC cord-010092-uftc8inx 10099 7 genotyping genotyping NN cord-010092-uftc8inx 10099 8 was be VBD cord-010092-uftc8inx 10099 9 also also RB cord-010092-uftc8inx 10099 10 performed perform VBN cord-010092-uftc8inx 10099 11 . . . cord-010092-uftc8inx 10100 1 Results result NNS cord-010092-uftc8inx 10100 2 : : : cord-010092-uftc8inx 10101 1 All all DT cord-010092-uftc8inx 10101 2 of of IN cord-010092-uftc8inx 10101 3 the the DT cord-010092-uftc8inx 10101 4 donors donor NNS cord-010092-uftc8inx 10101 5 with with IN cord-010092-uftc8inx 10101 6 serologically serologically RB cord-010092-uftc8inx 10101 7 weak weak JJ cord-010092-uftc8inx 10101 8 reactions reaction NNS cord-010092-uftc8inx 10101 9 were be VBD cord-010092-uftc8inx 10101 10 confirmed confirm VBN cord-010092-uftc8inx 10101 11 to to TO cord-010092-uftc8inx 10101 12 be be VB cord-010092-uftc8inx 10101 13 weak weak JJ cord-010092-uftc8inx 10101 14 D d NN cord-010092-uftc8inx 10101 15 variants variant NNS cord-010092-uftc8inx 10101 16 by by IN cord-010092-uftc8inx 10101 17 genotyping genotype VBG cord-010092-uftc8inx 10101 18 except except IN cord-010092-uftc8inx 10101 19 one one CD cord-010092-uftc8inx 10101 20 donor donor NN cord-010092-uftc8inx 10101 21 whose whose WP$ cord-010092-uftc8inx 10101 22 IAT IAT NNP cord-010092-uftc8inx 10101 23 was be VBD cord-010092-uftc8inx 10101 24 false false JJ cord-010092-uftc8inx 10101 25 positive positive JJ cord-010092-uftc8inx 10101 26 due due IN cord-010092-uftc8inx 10101 27 to to IN cord-010092-uftc8inx 10101 28 RBC RBC NNP cord-010092-uftc8inx 10101 29 autoantibodies autoantibody NNS cord-010092-uftc8inx 10101 30 . . . cord-010092-uftc8inx 10102 1 The the DT cord-010092-uftc8inx 10102 2 frequency frequency NN cord-010092-uftc8inx 10102 3 of of IN cord-010092-uftc8inx 10102 4 D d NN cord-010092-uftc8inx 10102 5 variant variant NN cord-010092-uftc8inx 10102 6 genotypes genotype NNS cord-010092-uftc8inx 10102 7 was be VBD cord-010092-uftc8inx 10102 8 as as IN cord-010092-uftc8inx 10102 9 follows follow VBZ cord-010092-uftc8inx 10102 10 : : : cord-010092-uftc8inx 10102 11 62 62 CD cord-010092-uftc8inx 10102 12 % % NN cord-010092-uftc8inx 10102 13 weak weak JJ cord-010092-uftc8inx 10102 14 D d NN cord-010092-uftc8inx 10102 15 type type NN cord-010092-uftc8inx 10102 16 1 1 CD cord-010092-uftc8inx 10102 17 , , , cord-010092-uftc8inx 10102 18 28 28 CD cord-010092-uftc8inx 10102 19 % % NN cord-010092-uftc8inx 10102 20 weak weak JJ cord-010092-uftc8inx 10102 21 D d NN cord-010092-uftc8inx 10102 22 type type NN cord-010092-uftc8inx 10102 23 3 3 CD cord-010092-uftc8inx 10102 24 , , , cord-010092-uftc8inx 10102 25 one one CD cord-010092-uftc8inx 10102 26 donor donor NN cord-010092-uftc8inx 10102 27 was be VBD cord-010092-uftc8inx 10102 28 typed type VBN cord-010092-uftc8inx 10102 29 as as IN cord-010092-uftc8inx 10102 30 weak weak JJ cord-010092-uftc8inx 10102 31 D d NN cord-010092-uftc8inx 10102 32 type type NN cord-010092-uftc8inx 10102 33 14 14 CD cord-010092-uftc8inx 10102 34 and and CC cord-010092-uftc8inx 10102 35 another another DT cord-010092-uftc8inx 10102 36 one one NN cord-010092-uftc8inx 10102 37 as as IN cord-010092-uftc8inx 10102 38 weak weak JJ cord-010092-uftc8inx 10102 39 D d NN cord-010092-uftc8inx 10102 40 type type NN cord-010092-uftc8inx 10102 41 11 11 CD cord-010092-uftc8inx 10102 42 . . . cord-010092-uftc8inx 10103 1 These these DT cord-010092-uftc8inx 10103 2 weak weak JJ cord-010092-uftc8inx 10103 3 D d NN cord-010092-uftc8inx 10103 4 types type NNS cord-010092-uftc8inx 10103 5 were be VBD cord-010092-uftc8inx 10103 6 associated associate VBN cord-010092-uftc8inx 10103 7 with with IN cord-010092-uftc8inx 10103 8 different different JJ cord-010092-uftc8inx 10103 9 degrees degree NNS cord-010092-uftc8inx 10103 10 of of IN cord-010092-uftc8inx 10103 11 serologically serologically RB cord-010092-uftc8inx 10103 12 determined determine VBN cord-010092-uftc8inx 10103 13 weakness weakness NN cord-010092-uftc8inx 10103 14 ranging range VBG cord-010092-uftc8inx 10103 15 from from IN cord-010092-uftc8inx 10103 16 negative negative JJ cord-010092-uftc8inx 10103 17 to to IN cord-010092-uftc8inx 10103 18 weak weak JJ cord-010092-uftc8inx 10103 19 positive positive JJ cord-010092-uftc8inx 10103 20 reactions reaction NNS cord-010092-uftc8inx 10103 21 concerning concern VBG cord-010092-uftc8inx 10103 22 slide slide NN cord-010092-uftc8inx 10103 23 and and CC cord-010092-uftc8inx 10103 24 MP MP NNP cord-010092-uftc8inx 10103 25 . . . cord-010092-uftc8inx 10104 1 All all DT cord-010092-uftc8inx 10104 2 of of IN cord-010092-uftc8inx 10104 3 them -PRON- PRP cord-010092-uftc8inx 10104 4 gave give VBD cord-010092-uftc8inx 10104 5 positive positive JJ cord-010092-uftc8inx 10104 6 reaction reaction NN cord-010092-uftc8inx 10104 7 ranging range VBG cord-010092-uftc8inx 10104 8 from from IN cord-010092-uftc8inx 10104 9 2 2 CD cord-010092-uftc8inx 10104 10 + + CD cord-010092-uftc8inx 10104 11 to to IN cord-010092-uftc8inx 10104 12 4 4 CD cord-010092-uftc8inx 10104 13 + + CD cord-010092-uftc8inx 10104 14 with with IN cord-010092-uftc8inx 10104 15 IAT IAT NNP cord-010092-uftc8inx 10104 16 , , , cord-010092-uftc8inx 10104 17 except except IN cord-010092-uftc8inx 10104 18 for for IN cord-010092-uftc8inx 10104 19 the the DT cord-010092-uftc8inx 10104 20 weak weak JJ cord-010092-uftc8inx 10104 21 D D NNP cord-010092-uftc8inx 10104 22 type type NN cord-010092-uftc8inx 10104 23 11 11 CD cord-010092-uftc8inx 10104 24 with with IN cord-010092-uftc8inx 10104 25 the the DT cord-010092-uftc8inx 10104 26 score score NN cord-010092-uftc8inx 10104 27 of of IN cord-010092-uftc8inx 10104 28 < < NNP cord-010092-uftc8inx 10104 29 1 1 CD cord-010092-uftc8inx 10104 30 + + CC cord-010092-uftc8inx 10104 31 which which WDT cord-010092-uftc8inx 10104 32 gave give VBD cord-010092-uftc8inx 10104 33 negative negative JJ cord-010092-uftc8inx 10104 34 reaction reaction NN cord-010092-uftc8inx 10104 35 by by IN cord-010092-uftc8inx 10104 36 slide slide NN cord-010092-uftc8inx 10104 37 and and CC cord-010092-uftc8inx 10104 38 MP MP NNP cord-010092-uftc8inx 10104 39 and and CC cord-010092-uftc8inx 10104 40 inconclusive inconclusive JJ cord-010092-uftc8inx 10104 41 result result NN cord-010092-uftc8inx 10104 42 with with IN cord-010092-uftc8inx 10104 43 the the DT cord-010092-uftc8inx 10104 44 set set NN cord-010092-uftc8inx 10104 45 of of IN cord-010092-uftc8inx 10104 46 monoclonal monoclonal JJ cord-010092-uftc8inx 10104 47 anti anti JJ cord-010092-uftc8inx 10104 48 - - JJ cord-010092-uftc8inx 10104 49 D d JJ cord-010092-uftc8inx 10104 50 reagents reagent NNS cord-010092-uftc8inx 10104 51 for for IN cord-010092-uftc8inx 10104 52 partial partial JJ cord-010092-uftc8inx 10104 53 D d NN cord-010092-uftc8inx 10104 54 typing typing NN cord-010092-uftc8inx 10104 55 . . . cord-010092-uftc8inx 10105 1 The the DT cord-010092-uftc8inx 10105 2 percentage percentage NN cord-010092-uftc8inx 10105 3 of of IN cord-010092-uftc8inx 10105 4 donors donor NNS cord-010092-uftc8inx 10105 5 , , , cord-010092-uftc8inx 10105 6 who who WP cord-010092-uftc8inx 10105 7 , , , cord-010092-uftc8inx 10105 8 at at IN cord-010092-uftc8inx 10105 9 serological serological JJ cord-010092-uftc8inx 10105 10 typing typing NN cord-010092-uftc8inx 10105 11 were be VBD cord-010092-uftc8inx 10105 12 only only RB cord-010092-uftc8inx 10105 13 found find VBN cord-010092-uftc8inx 10105 14 to to TO cord-010092-uftc8inx 10105 15 be be VB cord-010092-uftc8inx 10105 16 D D NNP cord-010092-uftc8inx 10105 17 positive positive JJ cord-010092-uftc8inx 10105 18 in in IN cord-010092-uftc8inx 10105 19 the the DT cord-010092-uftc8inx 10105 20 IAT IAT NNP cord-010092-uftc8inx 10105 21 was be VBD cord-010092-uftc8inx 10105 22 19 19 CD cord-010092-uftc8inx 10105 23 % % NN cord-010092-uftc8inx 10105 24 . . . cord-010092-uftc8inx 10106 1 One one CD cord-010092-uftc8inx 10106 2 of of IN cord-010092-uftc8inx 10106 3 the the DT cord-010092-uftc8inx 10106 4 weak weak JJ cord-010092-uftc8inx 10106 5 D D NNP cord-010092-uftc8inx 10106 6 type type NN cord-010092-uftc8inx 10106 7 1 1 CD cord-010092-uftc8inx 10106 8 donors donor NNS cord-010092-uftc8inx 10106 9 was be VBD cord-010092-uftc8inx 10106 10 negative negative JJ cord-010092-uftc8inx 10106 11 with with IN cord-010092-uftc8inx 10106 12 DVI dvi NN cord-010092-uftc8inx 10106 13 - - , cord-010092-uftc8inx 10106 14 and and CC cord-010092-uftc8inx 10106 15 positive positive JJ cord-010092-uftc8inx 10106 16 with with IN cord-010092-uftc8inx 10106 17 DVI+ DVI+ NNP cord-010092-uftc8inx 10106 18 reagent reagent NN cord-010092-uftc8inx 10106 19 in in IN cord-010092-uftc8inx 10106 20 the the DT cord-010092-uftc8inx 10106 21 MP MP NNP cord-010092-uftc8inx 10106 22 . . . cord-010092-uftc8inx 10107 1 The the DT cord-010092-uftc8inx 10107 2 additional additional JJ cord-010092-uftc8inx 10107 3 Rh Rh NNP cord-010092-uftc8inx 10107 4 phenotype phenotype NN cord-010092-uftc8inx 10107 5 ( ( -LRB- cord-010092-uftc8inx 10107 6 genotype genotype NN cord-010092-uftc8inx 10107 7 ) ) -RRB- cord-010092-uftc8inx 10107 8 was be VBD cord-010092-uftc8inx 10107 9 Ccee Ccee NNP cord-010092-uftc8inx 10107 10 in in IN cord-010092-uftc8inx 10107 11 all all DT cord-010092-uftc8inx 10107 12 of of IN cord-010092-uftc8inx 10107 13 the the DT cord-010092-uftc8inx 10107 14 donors donor NNS cord-010092-uftc8inx 10107 15 except except IN cord-010092-uftc8inx 10107 16 in in IN cord-010092-uftc8inx 10107 17 the the DT cord-010092-uftc8inx 10107 18 one one NN cord-010092-uftc8inx 10107 19 who who WP cord-010092-uftc8inx 10107 20 was be VBD cord-010092-uftc8inx 10107 21 genotyped genotype VBN cord-010092-uftc8inx 10107 22 as as IN cord-010092-uftc8inx 10107 23 weak weak JJ cord-010092-uftc8inx 10107 24 D d NN cord-010092-uftc8inx 10107 25 type type NN cord-010092-uftc8inx 10107 26 14 14 CD cord-010092-uftc8inx 10107 27 , , , cord-010092-uftc8inx 10107 28 as as RB cord-010092-uftc8inx 10107 29 well well RB cord-010092-uftc8inx 10107 30 as as IN cord-010092-uftc8inx 10107 31 in in IN cord-010092-uftc8inx 10107 32 the the DT cord-010092-uftc8inx 10107 33 D d JJ cord-010092-uftc8inx 10107 34 negative negative JJ cord-010092-uftc8inx 10107 35 donor donor NN cord-010092-uftc8inx 10107 36 , , , cord-010092-uftc8inx 10107 37 being be VBG cord-010092-uftc8inx 10107 38 ccee ccee NNP cord-010092-uftc8inx 10107 39 . . . cord-010092-uftc8inx 10108 1 Summary Summary NNP cord-010092-uftc8inx 10108 2 / / SYM cord-010092-uftc8inx 10108 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 10108 4 : : : cord-010092-uftc8inx 10109 1 Further further JJ cord-010092-uftc8inx 10109 2 RHD RHD NNP cord-010092-uftc8inx 10109 3 genotyping genotyping NN cord-010092-uftc8inx 10109 4 is be VBZ cord-010092-uftc8inx 10109 5 required require VBN cord-010092-uftc8inx 10109 6 to to TO cord-010092-uftc8inx 10109 7 estimate estimate VB cord-010092-uftc8inx 10109 8 the the DT cord-010092-uftc8inx 10109 9 actual actual JJ cord-010092-uftc8inx 10109 10 frequency frequency NN cord-010092-uftc8inx 10109 11 of of IN cord-010092-uftc8inx 10109 12 D d NN cord-010092-uftc8inx 10109 13 variants variant NNS cord-010092-uftc8inx 10109 14 in in IN cord-010092-uftc8inx 10109 15 our -PRON- PRP$ cord-010092-uftc8inx 10109 16 blood blood NN cord-010092-uftc8inx 10109 17 donors donor NNS cord-010092-uftc8inx 10109 18 . . . cord-010092-uftc8inx 10110 1 In in IN cord-010092-uftc8inx 10110 2 practice practice NN cord-010092-uftc8inx 10110 3 , , , cord-010092-uftc8inx 10110 4 current current JJ cord-010092-uftc8inx 10110 5 serological serological JJ cord-010092-uftc8inx 10110 6 methods method NNS cord-010092-uftc8inx 10110 7 are be VBP cord-010092-uftc8inx 10110 8 sufficient sufficient JJ cord-010092-uftc8inx 10110 9 to to TO cord-010092-uftc8inx 10110 10 detect detect VB cord-010092-uftc8inx 10110 11 almost almost RB cord-010092-uftc8inx 10110 12 all all DT cord-010092-uftc8inx 10110 13 variant variant JJ cord-010092-uftc8inx 10110 14 D d NN cord-010092-uftc8inx 10110 15 phenotypes phenotype NNS cord-010092-uftc8inx 10110 16 . . . cord-010092-uftc8inx 10111 1 There there EX cord-010092-uftc8inx 10111 2 is be VBZ cord-010092-uftc8inx 10111 3 a a DT cord-010092-uftc8inx 10111 4 consensus consensus NN cord-010092-uftc8inx 10111 5 that that WDT cord-010092-uftc8inx 10111 6 routine routine JJ cord-010092-uftc8inx 10111 7 molecular molecular JJ cord-010092-uftc8inx 10111 8 D d NN cord-010092-uftc8inx 10111 9 antigen antigen NN cord-010092-uftc8inx 10111 10 screening screening NN cord-010092-uftc8inx 10111 11 in in IN cord-010092-uftc8inx 10111 12 D D NNP cord-010092-uftc8inx 10111 13 negative negative JJ cord-010092-uftc8inx 10111 14 donors donor NNS cord-010092-uftc8inx 10111 15 in in IN cord-010092-uftc8inx 10111 16 order order NN cord-010092-uftc8inx 10111 17 to to TO cord-010092-uftc8inx 10111 18 detect detect VB cord-010092-uftc8inx 10111 19 DEL DEL NNP cord-010092-uftc8inx 10111 20 variant variant NN cord-010092-uftc8inx 10111 21 when when WRB cord-010092-uftc8inx 10111 22 ddccee ddccee NNP cord-010092-uftc8inx 10111 23 phenotyped phenotype VBD cord-010092-uftc8inx 10111 24 red red JJ cord-010092-uftc8inx 10111 25 blood blood NN cord-010092-uftc8inx 10111 26 cell cell NN cord-010092-uftc8inx 10111 27 transfusion transfusion NN cord-010092-uftc8inx 10111 28 is be VBZ cord-010092-uftc8inx 10111 29 practiced practice VBN cord-010092-uftc8inx 10111 30 in in IN cord-010092-uftc8inx 10111 31 all all DT cord-010092-uftc8inx 10111 32 D d JJ cord-010092-uftc8inx 10111 33 negative negative JJ cord-010092-uftc8inx 10111 34 patients patient NNS cord-010092-uftc8inx 10111 35 does do VBZ cord-010092-uftc8inx 10111 36 not not RB cord-010092-uftc8inx 10111 37 seem seem VB cord-010092-uftc8inx 10111 38 to to TO cord-010092-uftc8inx 10111 39 be be VB cord-010092-uftc8inx 10111 40 cost cost NN cord-010092-uftc8inx 10111 41 - - HYPH cord-010092-uftc8inx 10111 42 effective effective JJ cord-010092-uftc8inx 10111 43 . . . cord-010092-uftc8inx 10112 1 Background background NN cord-010092-uftc8inx 10112 2 : : : cord-010092-uftc8inx 10113 1 Rh Rh NNP cord-010092-uftc8inx 10113 2 null null NN cord-010092-uftc8inx 10113 3 or or CC cord-010092-uftc8inx 10113 4 Rh Rh NNP cord-010092-uftc8inx 10113 5 mod mod NN cord-010092-uftc8inx 10114 1 -the -the NFP cord-010092-uftc8inx 10115 1 so so RB cord-010092-uftc8inx 10115 2 - - HYPH cord-010092-uftc8inx 10115 3 called call VBN cord-010092-uftc8inx 10115 4 Rh Rh NNP cord-010092-uftc8inx 10115 5 - - HYPH cord-010092-uftc8inx 10115 6 deficiency deficiency NN cord-010092-uftc8inx 10115 7 phenotypes phenotype NNS cord-010092-uftc8inx 10115 8 - - , cord-010092-uftc8inx 10115 9 are be VBP cord-010092-uftc8inx 10115 10 characterized characterize VBN cord-010092-uftc8inx 10115 11 by by IN cord-010092-uftc8inx 10115 12 a a DT cord-010092-uftc8inx 10115 13 null null JJ cord-010092-uftc8inx 10115 14 or or CC cord-010092-uftc8inx 10115 15 severely severely RB cord-010092-uftc8inx 10115 16 reduced reduce VBN cord-010092-uftc8inx 10115 17 RH RH NNP cord-010092-uftc8inx 10115 18 antigen antigen NN cord-010092-uftc8inx 10115 19 expression expression NN cord-010092-uftc8inx 10115 20 ( ( -LRB- cord-010092-uftc8inx 10115 21 including include VBG cord-010092-uftc8inx 10115 22 D D NNP cord-010092-uftc8inx 10115 23 , , , cord-010092-uftc8inx 10115 24 C C NNP cord-010092-uftc8inx 10115 25 / / SYM cord-010092-uftc8inx 10115 26 c c NN cord-010092-uftc8inx 10115 27 and and CC cord-010092-uftc8inx 10115 28 E/ e/ NN cord-010092-uftc8inx 10115 29 e e NN cord-010092-uftc8inx 10115 30 ) ) -RRB- cord-010092-uftc8inx 10115 31 , , , cord-010092-uftc8inx 10115 32 respectively respectively RB cord-010092-uftc8inx 10115 33 . . . cord-010092-uftc8inx 10116 1 Molecular molecular JJ cord-010092-uftc8inx 10116 2 genetic genetic JJ cord-010092-uftc8inx 10116 3 studies study NNS cord-010092-uftc8inx 10116 4 showed show VBD cord-010092-uftc8inx 10116 5 that that IN cord-010092-uftc8inx 10116 6 these these DT cord-010092-uftc8inx 10116 7 phenotypes phenotype NNS cord-010092-uftc8inx 10116 8 are be VBP cord-010092-uftc8inx 10116 9 transmitted transmit VBN cord-010092-uftc8inx 10116 10 in in IN cord-010092-uftc8inx 10116 11 an an DT cord-010092-uftc8inx 10116 12 autosomal autosomal JJ cord-010092-uftc8inx 10116 13 recessive recessive JJ cord-010092-uftc8inx 10116 14 manner manner NN cord-010092-uftc8inx 10116 15 . . . cord-010092-uftc8inx 10117 1 Rh Rh NNP cord-010092-uftc8inx 10117 2 null null JJ cord-010092-uftc8inx 10117 3 phenotype phenotype NN cord-010092-uftc8inx 10117 4 originates originate VBZ cord-010092-uftc8inx 10117 5 from from IN cord-010092-uftc8inx 10117 6 two two CD cord-010092-uftc8inx 10117 7 different different JJ cord-010092-uftc8inx 10117 8 molecular molecular JJ cord-010092-uftc8inx 10117 9 events event NNS cord-010092-uftc8inx 10117 10 giving give VBG cord-010092-uftc8inx 10117 11 rise rise NN cord-010092-uftc8inx 10117 12 to to IN cord-010092-uftc8inx 10117 13 the the DT cord-010092-uftc8inx 10117 14 amorph amorph JJ cord-010092-uftc8inx 10117 15 type type NN cord-010092-uftc8inx 10117 16 and and CC cord-010092-uftc8inx 10117 17 the the DT cord-010092-uftc8inx 10117 18 regulator regulator NN cord-010092-uftc8inx 10117 19 type type NN cord-010092-uftc8inx 10117 20 . . . cord-010092-uftc8inx 10118 1 The the DT cord-010092-uftc8inx 10118 2 former former JJ cord-010092-uftc8inx 10118 3 is be VBZ cord-010092-uftc8inx 10118 4 caused cause VBN cord-010092-uftc8inx 10118 5 by by IN cord-010092-uftc8inx 10118 6 homozygosity homozygosity NN cord-010092-uftc8inx 10118 7 for for IN cord-010092-uftc8inx 10118 8 silent silent JJ cord-010092-uftc8inx 10118 9 genes gene NNS cord-010092-uftc8inx 10118 10 at at IN cord-010092-uftc8inx 10118 11 RHD RHD NNP cord-010092-uftc8inx 10118 12 and and CC cord-010092-uftc8inx 10118 13 RHCE RHCE NNP cord-010092-uftc8inx 10118 14 loci locus NNS cord-010092-uftc8inx 10118 15 , , , cord-010092-uftc8inx 10118 16 caused cause VBN cord-010092-uftc8inx 10118 17 by by IN cord-010092-uftc8inx 10118 18 inactivating inactivate VBG cord-010092-uftc8inx 10118 19 mutations mutation NNS cord-010092-uftc8inx 10118 20 in in IN cord-010092-uftc8inx 10118 21 RHCE RHCE NNP cord-010092-uftc8inx 10118 22 and and CC cord-010092-uftc8inx 10118 23 deletion deletion NN cord-010092-uftc8inx 10118 24 of of IN cord-010092-uftc8inx 10118 25 RHD RHD NNP cord-010092-uftc8inx 10118 26 . . . cord-010092-uftc8inx 10119 1 On on IN cord-010092-uftc8inx 10119 2 the the DT cord-010092-uftc8inx 10119 3 other other JJ cord-010092-uftc8inx 10119 4 hand hand NN cord-010092-uftc8inx 10119 5 , , , cord-010092-uftc8inx 10119 6 the the DT cord-010092-uftc8inx 10119 7 regulator regulator NN cord-010092-uftc8inx 10119 8 Rh Rh NNP cord-010092-uftc8inx 10119 9 null null JJ cord-010092-uftc8inx 10119 10 type type NN cord-010092-uftc8inx 10119 11 as as RB cord-010092-uftc8inx 10119 12 well well RB cord-010092-uftc8inx 10119 13 as as IN cord-010092-uftc8inx 10119 14 the the DT cord-010092-uftc8inx 10119 15 Rh Rh NNP cord-010092-uftc8inx 10119 16 mod mod NN cord-010092-uftc8inx 10119 17 phenotype phenotype NN cord-010092-uftc8inx 10119 18 are be VBP cord-010092-uftc8inx 10119 19 attributed attribute VBN cord-010092-uftc8inx 10119 20 to to IN cord-010092-uftc8inx 10119 21 mutations mutation NNS cord-010092-uftc8inx 10119 22 in in IN cord-010092-uftc8inx 10119 23 RHAG RHAG NNP cord-010092-uftc8inx 10119 24 gene gene NN cord-010092-uftc8inx 10119 25 when when WRB cord-010092-uftc8inx 10119 26 in in IN cord-010092-uftc8inx 10119 27 homozygous homozygous JJ cord-010092-uftc8inx 10119 28 state state NN cord-010092-uftc8inx 10119 29 or or CC cord-010092-uftc8inx 10119 30 when when WRB cord-010092-uftc8inx 10119 31 in in IN cord-010092-uftc8inx 10119 32 heterozygosity heterozygosity NN cord-010092-uftc8inx 10119 33 with with IN cord-010092-uftc8inx 10119 34 another another DT cord-010092-uftc8inx 10119 35 RHAG RHAG NNP cord-010092-uftc8inx 10119 36 allele allele NN cord-010092-uftc8inx 10119 37 containing contain VBG cord-010092-uftc8inx 10119 38 an an DT cord-010092-uftc8inx 10119 39 inactivating inactivate VBG cord-010092-uftc8inx 10119 40 mutation mutation NN cord-010092-uftc8inx 10119 41 . . . cord-010092-uftc8inx 10120 1 A a DT cord-010092-uftc8inx 10120 2 functional functional JJ cord-010092-uftc8inx 10120 3 RhAG rhag NN cord-010092-uftc8inx 10120 4 is be VBZ cord-010092-uftc8inx 10120 5 essential essential JJ cord-010092-uftc8inx 10120 6 both both DT cord-010092-uftc8inx 10120 7 for for IN cord-010092-uftc8inx 10120 8 the the DT cord-010092-uftc8inx 10120 9 correct correct JJ cord-010092-uftc8inx 10120 10 Rh Rh NNP cord-010092-uftc8inx 10120 11 complex complex JJ cord-010092-uftc8inx 10120 12 assembly assembly NN cord-010092-uftc8inx 10120 13 and and CC cord-010092-uftc8inx 10120 14 Rh Rh NNP cord-010092-uftc8inx 10120 15 antigen antigen NN cord-010092-uftc8inx 10120 16 expression expression NN cord-010092-uftc8inx 10120 17 in in IN cord-010092-uftc8inx 10120 18 the the DT cord-010092-uftc8inx 10120 19 erythrocyte erythrocyte NN cord-010092-uftc8inx 10120 20 membrane membrane NN cord-010092-uftc8inx 10120 21 . . . cord-010092-uftc8inx 10121 1 Aims aim VBZ cord-010092-uftc8inx 10121 2 : : : cord-010092-uftc8inx 10122 1 The the DT cord-010092-uftc8inx 10122 2 aim aim NN cord-010092-uftc8inx 10122 3 of of IN cord-010092-uftc8inx 10122 4 this this DT cord-010092-uftc8inx 10122 5 study study NN cord-010092-uftc8inx 10122 6 was be VBD cord-010092-uftc8inx 10122 7 to to TO cord-010092-uftc8inx 10122 8 investigate investigate VB cord-010092-uftc8inx 10122 9 the the DT cord-010092-uftc8inx 10122 10 molecular molecular JJ cord-010092-uftc8inx 10122 11 genetic genetic JJ cord-010092-uftc8inx 10122 12 basis basis NN cord-010092-uftc8inx 10122 13 of of IN cord-010092-uftc8inx 10122 14 an an DT cord-010092-uftc8inx 10122 15 Argentinean argentinean JJ cord-010092-uftc8inx 10122 16 proband proband NN cord-010092-uftc8inx 10122 17 with with IN cord-010092-uftc8inx 10122 18 no no DT cord-010092-uftc8inx 10122 19 detectable detectable JJ cord-010092-uftc8inx 10122 20 D d NN cord-010092-uftc8inx 10122 21 , , , cord-010092-uftc8inx 10122 22 C C NNP cord-010092-uftc8inx 10122 23 , , , cord-010092-uftc8inx 10122 24 c c NNP cord-010092-uftc8inx 10122 25 , , , cord-010092-uftc8inx 10122 26 E e NN cord-010092-uftc8inx 10122 27 and and CC cord-010092-uftc8inx 10122 28 e e NN cord-010092-uftc8inx 10122 29 antigens antigen NNS cord-010092-uftc8inx 10122 30 by by IN cord-010092-uftc8inx 10122 31 standard standard JJ cord-010092-uftc8inx 10122 32 serological serological JJ cord-010092-uftc8inx 10122 33 techniques technique NNS cord-010092-uftc8inx 10122 34 . . . cord-010092-uftc8inx 10123 1 Methods method NNS cord-010092-uftc8inx 10123 2 : : : cord-010092-uftc8inx 10123 3 Blood blood NN cord-010092-uftc8inx 10123 4 samples sample NNS cord-010092-uftc8inx 10123 5 were be VBD cord-010092-uftc8inx 10123 6 collected collect VBN cord-010092-uftc8inx 10123 7 from from IN cord-010092-uftc8inx 10123 8 the the DT cord-010092-uftc8inx 10123 9 proband proband NN cord-010092-uftc8inx 10123 10 , , , cord-010092-uftc8inx 10123 11 her -PRON- PRP$ cord-010092-uftc8inx 10123 12 parents parent NNS cord-010092-uftc8inx 10123 13 and and CC cord-010092-uftc8inx 10123 14 sister sister NN cord-010092-uftc8inx 10123 15 . . . cord-010092-uftc8inx 10124 1 The the DT cord-010092-uftc8inx 10124 2 proband proband NN cord-010092-uftc8inx 10124 3 was be VBD cord-010092-uftc8inx 10124 4 a a DT cord-010092-uftc8inx 10124 5 14 14 CD cord-010092-uftc8inx 10124 6 year year NN cord-010092-uftc8inx 10124 7 - - HYPH cord-010092-uftc8inx 10124 8 old old JJ cord-010092-uftc8inx 10124 9 young young JJ cord-010092-uftc8inx 10124 10 woman woman NN cord-010092-uftc8inx 10124 11 with with IN cord-010092-uftc8inx 10124 12 parameters parameter NNS cord-010092-uftc8inx 10124 13 of of IN cord-010092-uftc8inx 10124 14 hemolytic hemolytic JJ cord-010092-uftc8inx 10124 15 anemia anemia NN cord-010092-uftc8inx 10124 16 : : : cord-010092-uftc8inx 10124 17 low low JJ cord-010092-uftc8inx 10124 18 hemoglobin hemoglobin NN cord-010092-uftc8inx 10124 19 level level NN cord-010092-uftc8inx 10124 20 ( ( -LRB- cord-010092-uftc8inx 10124 21 10 10 CD cord-010092-uftc8inx 10124 22 g g NN cord-010092-uftc8inx 10124 23 / / SYM cord-010092-uftc8inx 10124 24 dL dl NN cord-010092-uftc8inx 10124 25 ) ) -RRB- cord-010092-uftc8inx 10124 26 , , , cord-010092-uftc8inx 10124 27 reticulocytosis reticulocytosis NNP cord-010092-uftc8inx 10124 28 ( ( -LRB- cord-010092-uftc8inx 10124 29 14 14 CD cord-010092-uftc8inx 10124 30 % % NN cord-010092-uftc8inx 10124 31 ) ) -RRB- cord-010092-uftc8inx 10124 32 , , , cord-010092-uftc8inx 10124 33 hyperbilirubinemia hyperbilirubinemia NNP cord-010092-uftc8inx 10124 34 , , , cord-010092-uftc8inx 10124 35 increased increase VBD cord-010092-uftc8inx 10124 36 LDH LDH NNP cord-010092-uftc8inx 10124 37 and and CC cord-010092-uftc8inx 10124 38 marked mark VBD cord-010092-uftc8inx 10124 39 spherocytosis spherocytosis NN cord-010092-uftc8inx 10124 40 . . . cord-010092-uftc8inx 10125 1 The the DT cord-010092-uftc8inx 10125 2 D d NN cord-010092-uftc8inx 10125 3 , , , cord-010092-uftc8inx 10125 4 C C NNP cord-010092-uftc8inx 10125 5 , , , cord-010092-uftc8inx 10125 6 c c NNP cord-010092-uftc8inx 10125 7 , , , cord-010092-uftc8inx 10125 8 E e NN cord-010092-uftc8inx 10125 9 and and CC cord-010092-uftc8inx 10125 10 e e NN cord-010092-uftc8inx 10125 11 status status NN cord-010092-uftc8inx 10125 12 was be VBD cord-010092-uftc8inx 10125 13 determined determine VBN cord-010092-uftc8inx 10125 14 by by IN cord-010092-uftc8inx 10125 15 standard standard JJ cord-010092-uftc8inx 10125 16 serologic serologic JJ cord-010092-uftc8inx 10125 17 hemagglutination hemagglutination NN cord-010092-uftc8inx 10125 18 techniques technique NNS cord-010092-uftc8inx 10125 19 using use VBG cord-010092-uftc8inx 10125 20 specific specific JJ cord-010092-uftc8inx 10125 21 monoclonal monoclonal JJ cord-010092-uftc8inx 10125 22 antibodies antibody NNS cord-010092-uftc8inx 10125 23 . . . cord-010092-uftc8inx 10126 1 Genomic genomic JJ cord-010092-uftc8inx 10126 2 DNA dna NN cord-010092-uftc8inx 10126 3 was be VBD cord-010092-uftc8inx 10126 4 isolated isolate VBN cord-010092-uftc8inx 10126 5 using use VBG cord-010092-uftc8inx 10126 6 a a DT cord-010092-uftc8inx 10126 7 modified modify VBN cord-010092-uftc8inx 10126 8 salting salting NN cord-010092-uftc8inx 10126 9 - - HYPH cord-010092-uftc8inx 10126 10 out out RP cord-010092-uftc8inx 10126 11 method method NN cord-010092-uftc8inx 10126 12 . . . cord-010092-uftc8inx 10127 1 DNA dna NN cord-010092-uftc8inx 10127 2 samples sample NNS cord-010092-uftc8inx 10127 3 were be VBD cord-010092-uftc8inx 10127 4 initially initially RB cord-010092-uftc8inx 10127 5 screened screen VBN cord-010092-uftc8inx 10127 6 for for IN cord-010092-uftc8inx 10127 7 the the DT cord-010092-uftc8inx 10127 8 presence presence NN cord-010092-uftc8inx 10127 9 of of IN cord-010092-uftc8inx 10127 10 intron intron NNP cord-010092-uftc8inx 10127 11 4 4 CD cord-010092-uftc8inx 10127 12 and and CC cord-010092-uftc8inx 10127 13 the the DT cord-010092-uftc8inx 10127 14 3 3 CD cord-010092-uftc8inx 10127 15 0 0 CD cord-010092-uftc8inx 10127 16 untranslated untranslated JJ cord-010092-uftc8inx 10127 17 region region NN cord-010092-uftc8inx 10127 18 of of IN cord-010092-uftc8inx 10127 19 the the DT cord-010092-uftc8inx 10127 20 RHD RHD NNP cord-010092-uftc8inx 10127 21 gene gene NN cord-010092-uftc8inx 10127 22 using use VBG cord-010092-uftc8inx 10127 23 PCR PCR NNP cord-010092-uftc8inx 10127 24 strategies strategy NNS cord-010092-uftc8inx 10127 25 . . . cord-010092-uftc8inx 10128 1 RHC RHC NNP cord-010092-uftc8inx 10128 2 / / SYM cord-010092-uftc8inx 10128 3 c c NN cord-010092-uftc8inx 10128 4 , , , cord-010092-uftc8inx 10128 5 and and CC cord-010092-uftc8inx 10128 6 RHE RHE NNP cord-010092-uftc8inx 10128 7 / / SYM cord-010092-uftc8inx 10128 8 e e NN cord-010092-uftc8inx 10128 9 alleles allele NNS cord-010092-uftc8inx 10128 10 were be VBD cord-010092-uftc8inx 10128 11 studied study VBN cord-010092-uftc8inx 10128 12 by by IN cord-010092-uftc8inx 10128 13 allele allele NN cord-010092-uftc8inx 10128 14 - - HYPH cord-010092-uftc8inx 10128 15 specific specific JJ cord-010092-uftc8inx 10128 16 PCRs pcr NNS cord-010092-uftc8inx 10128 17 to to TO cord-010092-uftc8inx 10128 18 determine determine VB cord-010092-uftc8inx 10128 19 the the DT cord-010092-uftc8inx 10128 20 RHCE RHCE NNP cord-010092-uftc8inx 10128 21 genotype genotype NN cord-010092-uftc8inx 10128 22 . . . cord-010092-uftc8inx 10129 1 RHD RHD NNP cord-010092-uftc8inx 10129 2 zygosity zygosity NNP cord-010092-uftc8inx 10129 3 was be VBD cord-010092-uftc8inx 10129 4 analyzed analyze VBN cord-010092-uftc8inx 10129 5 by by IN cord-010092-uftc8inx 10129 6 PCR PCR NNP cord-010092-uftc8inx 10129 7 - - HYPH cord-010092-uftc8inx 10129 8 RFLP RFLP NNP cord-010092-uftc8inx 10129 9 . . . cord-010092-uftc8inx 10130 1 RHD RHD NNP cord-010092-uftc8inx 10130 2 exon exon NN cord-010092-uftc8inx 10130 3 polymorphisms polymorphism NNS cord-010092-uftc8inx 10130 4 were be VBD cord-010092-uftc8inx 10130 5 studied study VBN cord-010092-uftc8inx 10130 6 by by IN cord-010092-uftc8inx 10130 7 RHD RHD NNP cord-010092-uftc8inx 10130 8 exon exon NN cord-010092-uftc8inx 10130 9 scanning scanning NN cord-010092-uftc8inx 10130 10 procedure procedure NN cord-010092-uftc8inx 10130 11 based base VBN cord-010092-uftc8inx 10130 12 on on IN cord-010092-uftc8inx 10130 13 PCR PCR NNP cord-010092-uftc8inx 10130 14 - - HYPH cord-010092-uftc8inx 10130 15 SSP SSP NNP cord-010092-uftc8inx 10130 16 . . . cord-010092-uftc8inx 10131 1 RHAG RHAG NNP cord-010092-uftc8inx 10131 2 gene gene NN cord-010092-uftc8inx 10131 3 was be VBD cord-010092-uftc8inx 10131 4 investigated investigate VBN cord-010092-uftc8inx 10131 5 by by IN cord-010092-uftc8inx 10131 6 exon exon NN cord-010092-uftc8inx 10131 7 - - HYPH cord-010092-uftc8inx 10131 8 specific specific JJ cord-010092-uftc8inx 10131 9 PCR pcr NN cord-010092-uftc8inx 10131 10 amplification amplification NN cord-010092-uftc8inx 10131 11 and and CC cord-010092-uftc8inx 10131 12 Sanger Sanger NNP cord-010092-uftc8inx 10131 13 sequencing sequencing NN cord-010092-uftc8inx 10131 14 . . . cord-010092-uftc8inx 10132 1 Results result NNS cord-010092-uftc8inx 10132 2 : : : cord-010092-uftc8inx 10133 1 No no DT cord-010092-uftc8inx 10133 2 D d NN cord-010092-uftc8inx 10133 3 , , , cord-010092-uftc8inx 10133 4 C C NNP cord-010092-uftc8inx 10133 5 , , , cord-010092-uftc8inx 10133 6 c c NNP cord-010092-uftc8inx 10133 7 , , , cord-010092-uftc8inx 10133 8 E e NN cord-010092-uftc8inx 10133 9 and and CC cord-010092-uftc8inx 10133 10 e e NN cord-010092-uftc8inx 10133 11 antigens antigen NNS cord-010092-uftc8inx 10133 12 were be VBD cord-010092-uftc8inx 10133 13 detected detect VBN cord-010092-uftc8inx 10133 14 in in IN cord-010092-uftc8inx 10133 15 the the DT cord-010092-uftc8inx 10133 16 proband proband NN cord-010092-uftc8inx 10133 17 's 's POS cord-010092-uftc8inx 10133 18 erythrocytes erythrocyte NNS cord-010092-uftc8inx 10133 19 . . . cord-010092-uftc8inx 10134 1 The the DT cord-010092-uftc8inx 10134 2 father father NN cord-010092-uftc8inx 10134 3 and and CC cord-010092-uftc8inx 10134 4 sister sister NN cord-010092-uftc8inx 10134 5 Rh Rh NNP cord-010092-uftc8inx 10134 6 phenotype phenotype NN cord-010092-uftc8inx 10134 7 was be VBD cord-010092-uftc8inx 10134 8 : : : cord-010092-uftc8inx 10134 9 D+ D+ NNP cord-010092-uftc8inx 10134 10 , , , cord-010092-uftc8inx 10134 11 C+ C+ NNP cord-010092-uftc8inx 10134 12 , , , cord-010092-uftc8inx 10134 13 c+ c+ NNP cord-010092-uftc8inx 10134 14 , , , cord-010092-uftc8inx 10134 15 E+ E+ NNP cord-010092-uftc8inx 10134 16 , , , cord-010092-uftc8inx 10134 17 e+ e+ NNP cord-010092-uftc8inx 10134 18 whereas whereas IN cord-010092-uftc8inx 10134 19 the the DT cord-010092-uftc8inx 10134 20 mother mother NN cord-010092-uftc8inx 10134 21 Rh Rh NNP cord-010092-uftc8inx 10134 22 phenotype phenotype NN cord-010092-uftc8inx 10134 23 was be VBD cord-010092-uftc8inx 10134 24 : : : cord-010092-uftc8inx 10134 25 D+ D+ NNP cord-010092-uftc8inx 10134 26 , , , cord-010092-uftc8inx 10134 27 C+ C+ NNP cord-010092-uftc8inx 10134 28 , , , cord-010092-uftc8inx 10134 29 c- c- XX cord-010092-uftc8inx 10134 30 , , , cord-010092-uftc8inx 10134 31 E- E- NNP cord-010092-uftc8inx 10134 32 , , , cord-010092-uftc8inx 10134 33 e+ e+ NNP cord-010092-uftc8inx 10134 34 . . . cord-010092-uftc8inx 10135 1 RH RH NNP cord-010092-uftc8inx 10135 2 genotyping genotyping NN cord-010092-uftc8inx 10135 3 confirmed confirm VBD cord-010092-uftc8inx 10135 4 the the DT cord-010092-uftc8inx 10135 5 Rh Rh NNP cord-010092-uftc8inx 10135 6 phenotypes phenotype NNS cord-010092-uftc8inx 10135 7 for for IN cord-010092-uftc8inx 10135 8 all all DT cord-010092-uftc8inx 10135 9 family family NN cord-010092-uftc8inx 10135 10 members member NNS cord-010092-uftc8inx 10135 11 except except IN cord-010092-uftc8inx 10135 12 for for IN cord-010092-uftc8inx 10135 13 the the DT cord-010092-uftc8inx 10135 14 proposita proposita NN cord-010092-uftc8inx 10135 15 who who WP cord-010092-uftc8inx 10135 16 genotyped genotype VBD cord-010092-uftc8inx 10135 17 RHD+ RHD+ NNP cord-010092-uftc8inx 10135 18 , , , cord-010092-uftc8inx 10135 19 RHC+ RHC+ NNP cord-010092-uftc8inx 10135 20 and and CC cord-010092-uftc8inx 10135 21 RHe+ RHe+ NNP cord-010092-uftc8inx 10135 22 . . . cord-010092-uftc8inx 10136 1 All all DT cord-010092-uftc8inx 10136 2 samples sample NNS cord-010092-uftc8inx 10136 3 showed show VBD cord-010092-uftc8inx 10136 4 an an DT cord-010092-uftc8inx 10136 5 homozygous homozygous JJ cord-010092-uftc8inx 10136 6 status status NN cord-010092-uftc8inx 10136 7 for for IN cord-010092-uftc8inx 10136 8 the the DT cord-010092-uftc8inx 10136 9 RHD RHD NNP cord-010092-uftc8inx 10136 10 gene gene NN cord-010092-uftc8inx 10136 11 and and CC cord-010092-uftc8inx 10136 12 all all DT cord-010092-uftc8inx 10136 13 RHD RHD NNP cord-010092-uftc8inx 10136 14 exons exon NNS cord-010092-uftc8inx 10136 15 were be VBD cord-010092-uftc8inx 10136 16 detected detect VBN cord-010092-uftc8inx 10136 17 by by IN cord-010092-uftc8inx 10136 18 exon exon NN cord-010092-uftc8inx 10136 19 scanning scanning NN cord-010092-uftc8inx 10136 20 . . . cord-010092-uftc8inx 10137 1 Sequencing sequencing NN cord-010092-uftc8inx 10137 2 analysis analysis NN cord-010092-uftc8inx 10137 3 revealed reveal VBD cord-010092-uftc8inx 10137 4 an an DT cord-010092-uftc8inx 10137 5 homozygous homozygous JJ cord-010092-uftc8inx 10137 6 c.920C c.920c NN cord-010092-uftc8inx 10137 7 > > XX cord-010092-uftc8inx 10137 8 T t NN cord-010092-uftc8inx 10137 9 mutation mutation NN cord-010092-uftc8inx 10137 10 in in IN cord-010092-uftc8inx 10137 11 RHAG RHAG NNP cord-010092-uftc8inx 10137 12 exon exon NN cord-010092-uftc8inx 10137 13 6 6 CD cord-010092-uftc8inx 10137 14 in in IN cord-010092-uftc8inx 10137 15 the the DT cord-010092-uftc8inx 10137 16 proband proband NN cord-010092-uftc8inx 10137 17 whereas whereas IN cord-010092-uftc8inx 10137 18 the the DT cord-010092-uftc8inx 10137 19 rest rest NN cord-010092-uftc8inx 10137 20 of of IN cord-010092-uftc8inx 10137 21 the the DT cord-010092-uftc8inx 10137 22 family family NN cord-010092-uftc8inx 10137 23 showed show VBD cord-010092-uftc8inx 10137 24 an an DT cord-010092-uftc8inx 10137 25 heterozygous heterozygous JJ cord-010092-uftc8inx 10137 26 state state NN cord-010092-uftc8inx 10137 27 in in IN cord-010092-uftc8inx 10137 28 the the DT cord-010092-uftc8inx 10137 29 same same JJ cord-010092-uftc8inx 10137 30 nucleotide nucleotide JJ cord-010092-uftc8inx 10137 31 position position NN cord-010092-uftc8inx 10137 32 . . . cord-010092-uftc8inx 10138 1 The the DT cord-010092-uftc8inx 10138 2 c.920C c.920C NNP cord-010092-uftc8inx 10139 1 > > XX cord-010092-uftc8inx 10140 1 T T NNP cord-010092-uftc8inx 10140 2 mutation mutation NN cord-010092-uftc8inx 10140 3 is be VBZ cord-010092-uftc8inx 10140 4 responsible responsible JJ cord-010092-uftc8inx 10140 5 for for IN cord-010092-uftc8inx 10140 6 the the DT cord-010092-uftc8inx 10140 7 p. p. NN cord-010092-uftc8inx 10141 1 Ser307Phe ser307phe NN cord-010092-uftc8inx 10141 2 amino amino NN cord-010092-uftc8inx 10141 3 acid acid NN cord-010092-uftc8inx 10141 4 substitution substitution NN cord-010092-uftc8inx 10141 5 predicted predict VBN cord-010092-uftc8inx 10141 6 to to TO cord-010092-uftc8inx 10141 7 be be VB cord-010092-uftc8inx 10141 8 in in IN cord-010092-uftc8inx 10141 9 the the DT cord-010092-uftc8inx 10141 10 10 10 CD cord-010092-uftc8inx 10141 11 th th XX cord-010092-uftc8inx 10141 12 RhAG rhag NN cord-010092-uftc8inx 10141 13 glycoprotein glycoprotein NN cord-010092-uftc8inx 10141 14 transmembrane transmembrane NN cord-010092-uftc8inx 10141 15 segment segment NN cord-010092-uftc8inx 10141 16 . . . cord-010092-uftc8inx 10142 1 Summary Summary NNP cord-010092-uftc8inx 10142 2 / / SYM cord-010092-uftc8inx 10142 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 10142 4 : : : cord-010092-uftc8inx 10143 1 This this DT cord-010092-uftc8inx 10143 2 study study NN cord-010092-uftc8inx 10143 3 described describe VBD cord-010092-uftc8inx 10143 4 the the DT cord-010092-uftc8inx 10143 5 molecular molecular JJ cord-010092-uftc8inx 10143 6 background background NN cord-010092-uftc8inx 10143 7 responsible responsible JJ cord-010092-uftc8inx 10143 8 for for IN cord-010092-uftc8inx 10143 9 an an DT cord-010092-uftc8inx 10143 10 Rh Rh NNP cord-010092-uftc8inx 10143 11 - - HYPH cord-010092-uftc8inx 10143 12 deficiency deficiency NN cord-010092-uftc8inx 10143 13 phenotype phenotype NN cord-010092-uftc8inx 10143 14 in in IN cord-010092-uftc8inx 10143 15 an an DT cord-010092-uftc8inx 10143 16 Argentinean argentinean JJ cord-010092-uftc8inx 10143 17 proband proband NN cord-010092-uftc8inx 10143 18 . . . cord-010092-uftc8inx 10144 1 We -PRON- PRP cord-010092-uftc8inx 10144 2 identified identify VBD cord-010092-uftc8inx 10144 3 the the DT cord-010092-uftc8inx 10144 4 novel novel NN cord-010092-uftc8inx 10144 5 missense missense NN cord-010092-uftc8inx 10144 6 mutation mutation NN cord-010092-uftc8inx 10145 1 c.920C c.920C NNP cord-010092-uftc8inx 10146 1 > > XX cord-010092-uftc8inx 10147 1 T T NNP cord-010092-uftc8inx 10147 2 in in IN cord-010092-uftc8inx 10147 3 the the DT cord-010092-uftc8inx 10147 4 RHAG RHAG NNP cord-010092-uftc8inx 10147 5 gene gene NN cord-010092-uftc8inx 10147 6 which which WDT cord-010092-uftc8inx 10147 7 results result VBZ cord-010092-uftc8inx 10147 8 in in IN cord-010092-uftc8inx 10147 9 the the DT cord-010092-uftc8inx 10147 10 Ser Ser NNP cord-010092-uftc8inx 10147 11 to to IN cord-010092-uftc8inx 10147 12 Phe Phe NNP cord-010092-uftc8inx 10147 13 single single JJ cord-010092-uftc8inx 10147 14 amino amino NN cord-010092-uftc8inx 10147 15 acid acid NN cord-010092-uftc8inx 10147 16 substitution substitution NN cord-010092-uftc8inx 10147 17 that that WDT cord-010092-uftc8inx 10147 18 shows show VBZ cord-010092-uftc8inx 10147 19 to to TO cord-010092-uftc8inx 10147 20 be be VB cord-010092-uftc8inx 10147 21 critical critical JJ cord-010092-uftc8inx 10147 22 for for IN cord-010092-uftc8inx 10147 23 Rh Rh NNP cord-010092-uftc8inx 10147 24 antigen antigen NN cord-010092-uftc8inx 10147 25 complex complex JJ cord-010092-uftc8inx 10147 26 assembly assembly NN cord-010092-uftc8inx 10147 27 within within IN cord-010092-uftc8inx 10147 28 the the DT cord-010092-uftc8inx 10147 29 erythrocyte erythrocyte NN cord-010092-uftc8inx 10147 30 membrane membrane NN cord-010092-uftc8inx 10147 31 . . . cord-010092-uftc8inx 10148 1 Further further JJ cord-010092-uftc8inx 10148 2 studies study NNS cord-010092-uftc8inx 10148 3 are be VBP cord-010092-uftc8inx 10148 4 being be VBG cord-010092-uftc8inx 10148 5 performed perform VBN cord-010092-uftc8inx 10148 6 in in IN cord-010092-uftc8inx 10148 7 order order NN cord-010092-uftc8inx 10148 8 to to TO cord-010092-uftc8inx 10148 9 determine determine VB cord-010092-uftc8inx 10148 10 whether whether IN cord-010092-uftc8inx 10148 11 the the DT cord-010092-uftc8inx 10148 12 proband proband NN cord-010092-uftc8inx 10148 13 is be VBZ cord-010092-uftc8inx 10148 14 Rh Rh NNP cord-010092-uftc8inx 10148 15 null null NN cord-010092-uftc8inx 10148 16 or or CC cord-010092-uftc8inx 10148 17 Rh Rh NNP cord-010092-uftc8inx 10148 18 mod mod NN cord-010092-uftc8inx 10148 19 . . . cord-010092-uftc8inx 10149 1 Background background NN cord-010092-uftc8inx 10149 2 : : : cord-010092-uftc8inx 10150 1 Rh Rh NNP cord-010092-uftc8inx 10150 2 blood blood NN cord-010092-uftc8inx 10150 3 group group NN cord-010092-uftc8inx 10150 4 system system NN cord-010092-uftc8inx 10150 5 is be VBZ cord-010092-uftc8inx 10150 6 the the DT cord-010092-uftc8inx 10150 7 most most RBS cord-010092-uftc8inx 10150 8 immunogenetic immunogenetic JJ cord-010092-uftc8inx 10150 9 blood blood NN cord-010092-uftc8inx 10150 10 group group NN cord-010092-uftc8inx 10150 11 system system NN cord-010092-uftc8inx 10150 12 and and CC cord-010092-uftc8inx 10150 13 blood blood NN cord-010092-uftc8inx 10150 14 donor donor NN cord-010092-uftc8inx 10150 15 typing typing NN cord-010092-uftc8inx 10150 16 should should MD cord-010092-uftc8inx 10150 17 account account VB cord-010092-uftc8inx 10150 18 for for IN cord-010092-uftc8inx 10150 19 all all DT cord-010092-uftc8inx 10150 20 expressing express VBG cord-010092-uftc8inx 10150 21 antigens antigen NNS cord-010092-uftc8inx 10150 22 in in IN cord-010092-uftc8inx 10150 23 order order NN cord-010092-uftc8inx 10150 24 to to TO cord-010092-uftc8inx 10150 25 prevent prevent VB cord-010092-uftc8inx 10150 26 anti anti JJ cord-010092-uftc8inx 10150 27 - - JJ cord-010092-uftc8inx 10150 28 D d JJ cord-010092-uftc8inx 10150 29 alloimmunization alloimmunization NN cord-010092-uftc8inx 10150 30 . . . cord-010092-uftc8inx 10151 1 Aims aim VBZ cord-010092-uftc8inx 10151 2 : : : cord-010092-uftc8inx 10152 1 The the DT cord-010092-uftc8inx 10152 2 objective objective NN cord-010092-uftc8inx 10152 3 of of IN cord-010092-uftc8inx 10152 4 this this DT cord-010092-uftc8inx 10152 5 prospective prospective JJ cord-010092-uftc8inx 10152 6 study study NN cord-010092-uftc8inx 10152 7 was be VBD cord-010092-uftc8inx 10152 8 to to TO cord-010092-uftc8inx 10152 9 investigate investigate VB cord-010092-uftc8inx 10152 10 RHD RHD NNP cord-010092-uftc8inx 10152 11 alleles allele NNS cord-010092-uftc8inx 10152 12 among among IN cord-010092-uftc8inx 10152 13 blood blood NN cord-010092-uftc8inx 10152 14 donors donor NNS cord-010092-uftc8inx 10152 15 who who WP cord-010092-uftc8inx 10152 16 typed type VBD cord-010092-uftc8inx 10152 17 D D NNP cord-010092-uftc8inx 10152 18 - - HYPH cord-010092-uftc8inx 10152 19 by by IN cord-010092-uftc8inx 10152 20 serologic serologic JJ cord-010092-uftc8inx 10152 21 methods method NNS cord-010092-uftc8inx 10152 22 and and CC cord-010092-uftc8inx 10152 23 positive positive JJ cord-010092-uftc8inx 10152 24 for for IN cord-010092-uftc8inx 10152 25 C C NNP cord-010092-uftc8inx 10152 26 and/or and/or CC cord-010092-uftc8inx 10152 27 E. E. NNP cord-010092-uftc8inx 10153 1 For for IN cord-010092-uftc8inx 10153 2 this this DT cord-010092-uftc8inx 10153 3 reason reason NN cord-010092-uftc8inx 10153 4 we -PRON- PRP cord-010092-uftc8inx 10153 5 developed develop VBD cord-010092-uftc8inx 10153 6 an an DT cord-010092-uftc8inx 10153 7 easy easy JJ cord-010092-uftc8inx 10153 8 - - HYPH cord-010092-uftc8inx 10153 9 to to TO cord-010092-uftc8inx 10153 10 - - HYPH cord-010092-uftc8inx 10153 11 perform perform VB cord-010092-uftc8inx 10153 12 DNA dna NN cord-010092-uftc8inx 10153 13 - - HYPH cord-010092-uftc8inx 10153 14 based base VBN cord-010092-uftc8inx 10153 15 screening screening NN cord-010092-uftc8inx 10153 16 method method NN cord-010092-uftc8inx 10153 17 for for IN cord-010092-uftc8inx 10153 18 the the DT cord-010092-uftc8inx 10153 19 detection detection NN cord-010092-uftc8inx 10153 20 of of IN cord-010092-uftc8inx 10153 21 RHD RHD NNP cord-010092-uftc8inx 10153 22 gene gene NN cord-010092-uftc8inx 10153 23 and and CC cord-010092-uftc8inx 10153 24 positive positive JJ cord-010092-uftc8inx 10153 25 samples sample NNS cord-010092-uftc8inx 10153 26 were be VBD cord-010092-uftc8inx 10153 27 further further RB cord-010092-uftc8inx 10153 28 characterized characterize VBN cord-010092-uftc8inx 10153 29 by by IN cord-010092-uftc8inx 10153 30 two two CD cord-010092-uftc8inx 10153 31 commercial commercial JJ cord-010092-uftc8inx 10153 32 PCR PCR NNP cord-010092-uftc8inx 10153 33 - - HYPH cord-010092-uftc8inx 10153 34 SSP SSP NNP cord-010092-uftc8inx 10153 35 kits kit NNS cord-010092-uftc8inx 10153 36 . . . cord-010092-uftc8inx 10154 1 Methods method NNS cord-010092-uftc8inx 10154 2 : : : cord-010092-uftc8inx 10154 3 Of of IN cord-010092-uftc8inx 10154 4 15692 15692 CD cord-010092-uftc8inx 10154 5 individual individual JJ cord-010092-uftc8inx 10154 6 blood blood NN cord-010092-uftc8inx 10154 7 donors donor NNS cord-010092-uftc8inx 10154 8 within within IN cord-010092-uftc8inx 10154 9 a a DT cord-010092-uftc8inx 10154 10 15 15 CD cord-010092-uftc8inx 10154 11 month month NN cord-010092-uftc8inx 10154 12 period period NN cord-010092-uftc8inx 10154 13 , , , cord-010092-uftc8inx 10154 14 1688 1688 CD cord-010092-uftc8inx 10154 15 ( ( -LRB- cord-010092-uftc8inx 10154 16 10.76 10.76 CD cord-010092-uftc8inx 10154 17 % % NN cord-010092-uftc8inx 10154 18 ) ) -RRB- cord-010092-uftc8inx 10154 19 typed type VBN cord-010092-uftc8inx 10154 20 as as IN cord-010092-uftc8inx 10154 21 D D NNP cord-010092-uftc8inx 10154 22 - - HYPH cord-010092-uftc8inx 10154 23 with with IN cord-010092-uftc8inx 10154 24 standardized standardized JJ cord-010092-uftc8inx 10154 25 immunohematologic immunohematologic JJ cord-010092-uftc8inx 10154 26 methods method NNS cord-010092-uftc8inx 10154 27 including include VBG cord-010092-uftc8inx 10154 28 the the DT cord-010092-uftc8inx 10154 29 indirect indirect JJ cord-010092-uftc8inx 10154 30 antiglobulin antiglobulin NN cord-010092-uftc8inx 10154 31 test test NN cord-010092-uftc8inx 10154 32 ( ( -LRB- cord-010092-uftc8inx 10154 33 IAT IAT NNP cord-010092-uftc8inx 10154 34 ) ) -RRB- cord-010092-uftc8inx 10154 35 . . . cord-010092-uftc8inx 10155 1 Residual Residual NNP cord-010092-uftc8inx 10155 2 EDTA EDTA NNP cord-010092-uftc8inx 10155 3 - - HYPH cord-010092-uftc8inx 10155 4 anticoagulated anticoagulate VBN cord-010092-uftc8inx 10155 5 blood blood NN cord-010092-uftc8inx 10155 6 samples sample NNS cord-010092-uftc8inx 10155 7 were be VBD cord-010092-uftc8inx 10155 8 used use VBN cord-010092-uftc8inx 10155 9 to to TO cord-010092-uftc8inx 10155 10 isolate isolate VB cord-010092-uftc8inx 10155 11 genomic genomic JJ cord-010092-uftc8inx 10155 12 DNA dna NN cord-010092-uftc8inx 10155 13 using use VBG cord-010092-uftc8inx 10155 14 the the DT cord-010092-uftc8inx 10155 15 QIAamp QIAamp NNP cord-010092-uftc8inx 10155 16 DNA DNA NNP cord-010092-uftc8inx 10155 17 Blood Blood NNP cord-010092-uftc8inx 10155 18 Kit kit NN cord-010092-uftc8inx 10155 19 ( ( -LRB- cord-010092-uftc8inx 10155 20 QIAGEN QIAGEN NNP cord-010092-uftc8inx 10155 21 , , , cord-010092-uftc8inx 10155 22 Germany Germany NNP cord-010092-uftc8inx 10155 23 ) ) -RRB- cord-010092-uftc8inx 10155 24 from from IN cord-010092-uftc8inx 10155 25 112 112 CD cord-010092-uftc8inx 10155 26 out out IN cord-010092-uftc8inx 10155 27 of of IN cord-010092-uftc8inx 10155 28 151 151 CD cord-010092-uftc8inx 10155 29 ( ( -LRB- cord-010092-uftc8inx 10155 30 8.95 8.95 CD cord-010092-uftc8inx 10155 31 % % NN cord-010092-uftc8inx 10155 32 ) ) -RRB- cord-010092-uftc8inx 10155 33 C C NNP cord-010092-uftc8inx 10155 34 / / SYM cord-010092-uftc8inx 10155 35 E+ e+ VBP cord-010092-uftc8inx 10155 36 and and CC cord-010092-uftc8inx 10155 37 serologically serologically RB cord-010092-uftc8inx 10155 38 D D NNP cord-010092-uftc8inx 10155 39 - - HYPH cord-010092-uftc8inx 10155 40 donors donor NNS cord-010092-uftc8inx 10155 41 . . . cord-010092-uftc8inx 10156 1 All all DT cord-010092-uftc8inx 10156 2 DNA dna NN cord-010092-uftc8inx 10156 3 samples sample NNS cord-010092-uftc8inx 10156 4 were be VBD cord-010092-uftc8inx 10156 5 tested test VBN cord-010092-uftc8inx 10156 6 individually individually RB cord-010092-uftc8inx 10156 7 for for IN cord-010092-uftc8inx 10156 8 the the DT cord-010092-uftc8inx 10156 9 presence presence NN cord-010092-uftc8inx 10156 10 of of IN cord-010092-uftc8inx 10156 11 RHD RHD NNP cord-010092-uftc8inx 10156 12 - - HYPH cord-010092-uftc8inx 10156 13 specific specific JJ cord-010092-uftc8inx 10156 14 DNA dna NN cord-010092-uftc8inx 10156 15 sequences sequence NNS cord-010092-uftc8inx 10156 16 in in IN cord-010092-uftc8inx 10156 17 the the DT cord-010092-uftc8inx 10156 18 RHD RHD NNP cord-010092-uftc8inx 10156 19 promoter promoter NN cord-010092-uftc8inx 10156 20 , , , cord-010092-uftc8inx 10156 21 intron intron NNP cord-010092-uftc8inx 10156 22 4 4 CD cord-010092-uftc8inx 10156 23 , , , cord-010092-uftc8inx 10156 24 exon exon NN cord-010092-uftc8inx 10156 25 7 7 CD cord-010092-uftc8inx 10156 26 and and CC cord-010092-uftc8inx 10156 27 exon exon NN cord-010092-uftc8inx 10156 28 10 10 CD cord-010092-uftc8inx 10156 29 by by IN cord-010092-uftc8inx 10156 30 a a DT cord-010092-uftc8inx 10156 31 multiplex multiplex JJ cord-010092-uftc8inx 10156 32 PCR PCR NNP cord-010092-uftc8inx 10156 33 - - HYPH cord-010092-uftc8inx 10156 34 SSP SSP NNP cord-010092-uftc8inx 10156 35 method method NN cord-010092-uftc8inx 10156 36 . . . cord-010092-uftc8inx 10157 1 The the DT cord-010092-uftc8inx 10157 2 reaction reaction NN cord-010092-uftc8inx 10157 3 was be VBD cord-010092-uftc8inx 10157 4 conducted conduct VBN cord-010092-uftc8inx 10157 5 in in IN cord-010092-uftc8inx 10157 6 a a DT cord-010092-uftc8inx 10157 7 final final JJ cord-010092-uftc8inx 10157 8 volume volume NN cord-010092-uftc8inx 10157 9 of of IN cord-010092-uftc8inx 10157 10 20 20 CD cord-010092-uftc8inx 10157 11 lL lL NNS cord-010092-uftc8inx 10157 12 with with IN cord-010092-uftc8inx 10157 13 primers primer NNS cord-010092-uftc8inx 10157 14 that that WDT cord-010092-uftc8inx 10157 15 were be VBD cord-010092-uftc8inx 10157 16 applied apply VBN cord-010092-uftc8inx 10157 17 as as IN cord-010092-uftc8inx 10157 18 described describe VBN cord-010092-uftc8inx 10157 19 by by IN cord-010092-uftc8inx 10157 20 F. F. NNP cord-010092-uftc8inx 10157 21 Wagner Wagner NNP cord-010092-uftc8inx 10157 22 et et NNP cord-010092-uftc8inx 10157 23 al al NNP cord-010092-uftc8inx 10157 24 . . . cord-010092-uftc8inx 10158 1 ( ( -LRB- cord-010092-uftc8inx 10158 2 BMC BMC NNP cord-010092-uftc8inx 10158 3 Genetics Genetics NNP cord-010092-uftc8inx 10158 4 , , , cord-010092-uftc8inx 10158 5 2001 2001 CD cord-010092-uftc8inx 10158 6 ) ) -RRB- cord-010092-uftc8inx 10158 7 except except IN cord-010092-uftc8inx 10158 8 antisense antisense NNP cord-010092-uftc8inx 10158 9 primer primer NN cord-010092-uftc8inx 10158 10 for for IN cord-010092-uftc8inx 10158 11 exon exon NNP cord-010092-uftc8inx 10158 12 10 10 CD cord-010092-uftc8inx 10158 13 and and CC cord-010092-uftc8inx 10158 14 the the DT cord-010092-uftc8inx 10158 15 two two CD cord-010092-uftc8inx 10158 16 primers primer NNS cord-010092-uftc8inx 10158 17 amplifying amplify VBG cord-010092-uftc8inx 10158 18 an an DT cord-010092-uftc8inx 10158 19 HGH HGH NNP cord-010092-uftc8inx 10158 20 gene gene NN cord-010092-uftc8inx 10158 21 fragment fragment NN cord-010092-uftc8inx 10158 22 as as IN cord-010092-uftc8inx 10158 23 internal internal JJ cord-010092-uftc8inx 10158 24 control control NN cord-010092-uftc8inx 10158 25 , , , cord-010092-uftc8inx 10158 26 designed design VBN cord-010092-uftc8inx 10158 27 by by IN cord-010092-uftc8inx 10158 28 our -PRON- PRP$ cord-010092-uftc8inx 10158 29 laboratory laboratory NN cord-010092-uftc8inx 10158 30 . . . cord-010092-uftc8inx 10159 1 PCR PCR NNP cord-010092-uftc8inx 10159 2 products product NNS cord-010092-uftc8inx 10159 3 were be VBD cord-010092-uftc8inx 10159 4 visualized visualize VBN cord-010092-uftc8inx 10159 5 by by IN cord-010092-uftc8inx 10159 6 electrophoresis electrophoresis NN cord-010092-uftc8inx 10159 7 on on IN cord-010092-uftc8inx 10159 8 a a DT cord-010092-uftc8inx 10159 9 4 4 CD cord-010092-uftc8inx 10159 10 % % NN cord-010092-uftc8inx 10159 11 agarose agarose JJ cord-010092-uftc8inx 10159 12 gel gel NN cord-010092-uftc8inx 10159 13 with with IN cord-010092-uftc8inx 10159 14 ethidium ethidium NN cord-010092-uftc8inx 10159 15 bromide bromide NN cord-010092-uftc8inx 10159 16 staining staining NN cord-010092-uftc8inx 10159 17 . . . cord-010092-uftc8inx 10160 1 In in IN cord-010092-uftc8inx 10160 2 case case NN cord-010092-uftc8inx 10160 3 of of IN cord-010092-uftc8inx 10160 4 a a DT cord-010092-uftc8inx 10160 5 positive positive JJ cord-010092-uftc8inx 10160 6 reaction reaction NN cord-010092-uftc8inx 10160 7 the the DT cord-010092-uftc8inx 10160 8 sample sample NN cord-010092-uftc8inx 10160 9 was be VBD cord-010092-uftc8inx 10160 10 analyzed analyze VBN cord-010092-uftc8inx 10160 11 by by IN cord-010092-uftc8inx 10160 12 PCR PCR NNP cord-010092-uftc8inx 10160 13 - - HYPH cord-010092-uftc8inx 10160 14 SSP SSP NNP cord-010092-uftc8inx 10160 15 D D NNP cord-010092-uftc8inx 10160 16 weak weak JJ cord-010092-uftc8inx 10160 17 and and CC cord-010092-uftc8inx 10160 18 PCR PCR NNP cord-010092-uftc8inx 10160 19 - - HYPH cord-010092-uftc8inx 10160 20 SSP SSP NNP cord-010092-uftc8inx 10160 21 CDE CDE NNP cord-010092-uftc8inx 10161 1 ( ( -LRB- cord-010092-uftc8inx 10161 2 Inno Inno NNP cord-010092-uftc8inx 10161 3 - - HYPH cord-010092-uftc8inx 10161 4 train train NN cord-010092-uftc8inx 10161 5 , , , cord-010092-uftc8inx 10161 6 Germany Germany NNP cord-010092-uftc8inx 10161 7 ) ) -RRB- cord-010092-uftc8inx 10161 8 . . . cord-010092-uftc8inx 10162 1 Results result NNS cord-010092-uftc8inx 10162 2 : : : cord-010092-uftc8inx 10163 1 Out out IN cord-010092-uftc8inx 10163 2 of of IN cord-010092-uftc8inx 10163 3 112 112 CD cord-010092-uftc8inx 10163 4 D d NN cord-010092-uftc8inx 10163 5 - - HYPH cord-010092-uftc8inx 10163 6 individuals individual NNS cord-010092-uftc8inx 10163 7 analyzed analyze VBN cord-010092-uftc8inx 10163 8 , , , cord-010092-uftc8inx 10163 9 101 101 CD cord-010092-uftc8inx 10163 10 were be VBD cord-010092-uftc8inx 10163 11 ddCcee ddCcee NNP cord-010092-uftc8inx 10163 12 , , , cord-010092-uftc8inx 10163 13 8 8 CD cord-010092-uftc8inx 10163 14 ddccEe ddccee CD cord-010092-uftc8inx 10163 15 , , , cord-010092-uftc8inx 10163 16 2 2 CD cord-010092-uftc8inx 10163 17 ddCcEe ddccee NN cord-010092-uftc8inx 10163 18 and and CC cord-010092-uftc8inx 10163 19 one one CD cord-010092-uftc8inx 10163 20 had have VBD cord-010092-uftc8inx 10163 21 a a DT cord-010092-uftc8inx 10163 22 ddCCee ddccee JJ cord-010092-uftc8inx 10163 23 phenotype phenotype NN cord-010092-uftc8inx 10163 24 . . . cord-010092-uftc8inx 10164 1 Molecular molecular JJ cord-010092-uftc8inx 10164 2 analysis analysis NN cord-010092-uftc8inx 10164 3 showed show VBD cord-010092-uftc8inx 10164 4 that that IN cord-010092-uftc8inx 10164 5 104 104 CD cord-010092-uftc8inx 10164 6 ( ( -LRB- cord-010092-uftc8inx 10164 7 92.86 92.86 CD cord-010092-uftc8inx 10164 8 % % NN cord-010092-uftc8inx 10164 9 ) ) -RRB- cord-010092-uftc8inx 10164 10 were be VBD cord-010092-uftc8inx 10164 11 negative negative JJ cord-010092-uftc8inx 10164 12 for for IN cord-010092-uftc8inx 10164 13 all all DT cord-010092-uftc8inx 10164 14 four four CD cord-010092-uftc8inx 10164 15 RHD RHD NNP cord-010092-uftc8inx 10164 16 DNA dna NN cord-010092-uftc8inx 10164 17 regions region NNS cord-010092-uftc8inx 10164 18 . . . cord-010092-uftc8inx 10165 1 Among among IN cord-010092-uftc8inx 10165 2 the the DT cord-010092-uftc8inx 10165 3 other other JJ cord-010092-uftc8inx 10165 4 8 8 CD cord-010092-uftc8inx 10165 5 samples sample NNS cord-010092-uftc8inx 10165 6 , , , cord-010092-uftc8inx 10165 7 all all DT cord-010092-uftc8inx 10165 8 of of IN cord-010092-uftc8inx 10165 9 ddCcee ddCcee NNP cord-010092-uftc8inx 10165 10 phenotype phenotype NN cord-010092-uftc8inx 10165 11 , , , cord-010092-uftc8inx 10165 12 three three CD cord-010092-uftc8inx 10165 13 were be VBD cord-010092-uftc8inx 10165 14 found find VBN cord-010092-uftc8inx 10165 15 to to TO cord-010092-uftc8inx 10165 16 be be VB cord-010092-uftc8inx 10165 17 positive positive JJ cord-010092-uftc8inx 10165 18 for for IN cord-010092-uftc8inx 10165 19 RHD rhd NN cord-010092-uftc8inx 10165 20 promoter promoter NN cord-010092-uftc8inx 10165 21 , , , cord-010092-uftc8inx 10165 22 intron intron NNP cord-010092-uftc8inx 10165 23 4 4 CD cord-010092-uftc8inx 10165 24 , , , cord-010092-uftc8inx 10165 25 exon exon NN cord-010092-uftc8inx 10165 26 7 7 CD cord-010092-uftc8inx 10165 27 and and CC cord-010092-uftc8inx 10165 28 exon exon NN cord-010092-uftc8inx 10165 29 10 10 CD cord-010092-uftc8inx 10165 30 , , , cord-010092-uftc8inx 10165 31 three three CD cord-010092-uftc8inx 10165 32 for for IN cord-010092-uftc8inx 10165 33 RHD RHD NNP cord-010092-uftc8inx 10165 34 promoter promoter NN cord-010092-uftc8inx 10165 35 and and CC cord-010092-uftc8inx 10165 36 exon exon NN cord-010092-uftc8inx 10165 37 10 10 CD cord-010092-uftc8inx 10165 38 , , , cord-010092-uftc8inx 10165 39 and and CC cord-010092-uftc8inx 10165 40 two two CD cord-010092-uftc8inx 10165 41 for for IN cord-010092-uftc8inx 10165 42 exon exon NN cord-010092-uftc8inx 10165 43 10 10 CD cord-010092-uftc8inx 10165 44 alone alone RB cord-010092-uftc8inx 10165 45 . . . cord-010092-uftc8inx 10166 1 Further further JJ cord-010092-uftc8inx 10166 2 genotyping genotyping NN cord-010092-uftc8inx 10166 3 revealed reveal VBD cord-010092-uftc8inx 10166 4 five five CD cord-010092-uftc8inx 10166 5 hybrid hybrid JJ cord-010092-uftc8inx 10166 6 RHD RHD NNP cord-010092-uftc8inx 10166 7 - - HYPH cord-010092-uftc8inx 10166 8 CE CE NNP cord-010092-uftc8inx 10166 9 - - HYPH cord-010092-uftc8inx 10166 10 D d JJ cord-010092-uftc8inx 10166 11 alleles allele NNS cord-010092-uftc8inx 10166 12 [ [ -LRB- cord-010092-uftc8inx 10166 13 3 3 CD cord-010092-uftc8inx 10166 14 RHD RHD NNP cord-010092-uftc8inx 10166 15 - - HYPH cord-010092-uftc8inx 10166 16 CE(2 CE(2 NNP cord-010092-uftc8inx 10166 17 - - HYPH cord-010092-uftc8inx 10166 18 9)-D 9)-d NN cord-010092-uftc8inx 10166 19 and and CC cord-010092-uftc8inx 10166 20 2 2 CD cord-010092-uftc8inx 10166 21 RHD RHD NNP cord-010092-uftc8inx 10166 22 - - HYPH cord-010092-uftc8inx 10166 23 CE(3 CE(3 NNP cord-010092-uftc8inx 10166 24 - - HYPH cord-010092-uftc8inx 10166 25 7)-D 7)-D NNP cord-010092-uftc8inx 10166 26 ] ] -RRB- cord-010092-uftc8inx 10166 27 , , , cord-010092-uftc8inx 10166 28 one one CD cord-010092-uftc8inx 10166 29 allele allele NN cord-010092-uftc8inx 10166 30 represented represent VBD cord-010092-uftc8inx 10166 31 the the DT cord-010092-uftc8inx 10166 32 DEL(M295I DEL(M295I NNP cord-010092-uftc8inx 10166 33 ) ) -RRB- cord-010092-uftc8inx 10166 34 genotype genotype NN cord-010092-uftc8inx 10166 35 , , , cord-010092-uftc8inx 10166 36 while while IN cord-010092-uftc8inx 10166 37 the the DT cord-010092-uftc8inx 10166 38 remaining remain VBG cord-010092-uftc8inx 10166 39 two two CD cord-010092-uftc8inx 10166 40 samples sample NNS cord-010092-uftc8inx 10166 41 did do VBD cord-010092-uftc8inx 10166 42 not not RB cord-010092-uftc8inx 10166 43 show show VB cord-010092-uftc8inx 10166 44 an an DT cord-010092-uftc8inx 10166 45 allele allele NN cord-010092-uftc8inx 10166 46 that that WDT cord-010092-uftc8inx 10166 47 could could MD cord-010092-uftc8inx 10166 48 be be VB cord-010092-uftc8inx 10166 49 determined determine VBN cord-010092-uftc8inx 10166 50 with with IN cord-010092-uftc8inx 10166 51 the the DT cord-010092-uftc8inx 10166 52 PCR PCR NNP cord-010092-uftc8inx 10166 53 - - HYPH cord-010092-uftc8inx 10166 54 SSP SSP NNP cord-010092-uftc8inx 10166 55 kits kit NNS cord-010092-uftc8inx 10166 56 . . . cord-010092-uftc8inx 10167 1 Summary Summary NNP cord-010092-uftc8inx 10167 2 / / SYM cord-010092-uftc8inx 10167 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 10167 4 : : : cord-010092-uftc8inx 10168 1 Serotyping serotyping NN cord-010092-uftc8inx 10168 2 is be VBZ cord-010092-uftc8inx 10168 3 the the DT cord-010092-uftc8inx 10168 4 standard standard JJ cord-010092-uftc8inx 10168 5 method method NN cord-010092-uftc8inx 10168 6 to to TO cord-010092-uftc8inx 10168 7 assign assign VB cord-010092-uftc8inx 10168 8 transfusion transfusion NN cord-010092-uftc8inx 10168 9 strategies strategy NNS cord-010092-uftc8inx 10168 10 but but CC cord-010092-uftc8inx 10168 11 it -PRON- PRP cord-010092-uftc8inx 10168 12 is be VBZ cord-010092-uftc8inx 10168 13 not not RB cord-010092-uftc8inx 10168 14 always always RB cord-010092-uftc8inx 10168 15 capable capable JJ cord-010092-uftc8inx 10168 16 to to TO cord-010092-uftc8inx 10168 17 correctly correctly RB cord-010092-uftc8inx 10168 18 define define VB cord-010092-uftc8inx 10168 19 all all DT cord-010092-uftc8inx 10168 20 samples sample NNS cord-010092-uftc8inx 10168 21 that that WDT cord-010092-uftc8inx 10168 22 show show VBP cord-010092-uftc8inx 10168 23 weak weak JJ cord-010092-uftc8inx 10168 24 reactions reaction NNS cord-010092-uftc8inx 10168 25 in in IN cord-010092-uftc8inx 10168 26 D. D. NNP cord-010092-uftc8inx 10168 27 A a DT cord-010092-uftc8inx 10168 28 RHD RHD NNP cord-010092-uftc8inx 10168 29 genotyping genotyping NN cord-010092-uftc8inx 10168 30 strategy strategy NN cord-010092-uftc8inx 10168 31 is be VBZ cord-010092-uftc8inx 10168 32 needed need VBN cord-010092-uftc8inx 10168 33 to to TO cord-010092-uftc8inx 10168 34 confirm confirm VB cord-010092-uftc8inx 10168 35 D d NN cord-010092-uftc8inx 10168 36 - - HYPH cord-010092-uftc8inx 10168 37 blood blood NN cord-010092-uftc8inx 10168 38 donors donor NNS cord-010092-uftc8inx 10168 39 and and CC cord-010092-uftc8inx 10168 40 thus thus RB cord-010092-uftc8inx 10168 41 to to TO cord-010092-uftc8inx 10168 42 avoid avoid VB cord-010092-uftc8inx 10168 43 anti anti JJ cord-010092-uftc8inx 10168 44 - - JJ cord-010092-uftc8inx 10168 45 D d JJ cord-010092-uftc8inx 10168 46 immunizations immunization NNS cord-010092-uftc8inx 10168 47 . . . cord-010092-uftc8inx 10169 1 For for IN cord-010092-uftc8inx 10169 2 these these DT cord-010092-uftc8inx 10169 3 reasons reason NNS cord-010092-uftc8inx 10169 4 we -PRON- PRP cord-010092-uftc8inx 10169 5 suggest suggest VBP cord-010092-uftc8inx 10169 6 the the DT cord-010092-uftc8inx 10169 7 implementation implementation NN cord-010092-uftc8inx 10169 8 of of IN cord-010092-uftc8inx 10169 9 an an DT cord-010092-uftc8inx 10169 10 easy easy JJ cord-010092-uftc8inx 10169 11 and and CC cord-010092-uftc8inx 10169 12 possible possible JJ cord-010092-uftc8inx 10169 13 cost cost NN cord-010092-uftc8inx 10169 14 - - HYPH cord-010092-uftc8inx 10169 15 effective effective JJ cord-010092-uftc8inx 10169 16 method method NN cord-010092-uftc8inx 10169 17 . . . cord-010092-uftc8inx 10170 1 Background background NN cord-010092-uftc8inx 10170 2 : : : cord-010092-uftc8inx 10171 1 More More JJR cord-010092-uftc8inx 10171 2 than than IN cord-010092-uftc8inx 10171 3 100 100 CD cord-010092-uftc8inx 10171 4 weak weak JJ cord-010092-uftc8inx 10171 5 D d NN cord-010092-uftc8inx 10171 6 types type NNS cord-010092-uftc8inx 10171 7 have have VBP cord-010092-uftc8inx 10171 8 been be VBN cord-010092-uftc8inx 10171 9 described describe VBN cord-010092-uftc8inx 10171 10 to to IN cord-010092-uftc8inx 10171 11 date date NN cord-010092-uftc8inx 10171 12 . . . cord-010092-uftc8inx 10172 1 Transfusion transfusion NN cord-010092-uftc8inx 10172 2 recipients recipient NNS cord-010092-uftc8inx 10172 3 with with IN cord-010092-uftc8inx 10172 4 weak weak JJ cord-010092-uftc8inx 10172 5 D d NN cord-010092-uftc8inx 10172 6 type type NN cord-010092-uftc8inx 10172 7 1 1 CD cord-010092-uftc8inx 10172 8 , , , cord-010092-uftc8inx 10172 9 2 2 CD cord-010092-uftc8inx 10172 10 , , , cord-010092-uftc8inx 10172 11 or or CC cord-010092-uftc8inx 10172 12 3 3 CD cord-010092-uftc8inx 10172 13 are be VBP cord-010092-uftc8inx 10172 14 not not RB cord-010092-uftc8inx 10172 15 at at IN cord-010092-uftc8inx 10172 16 risk risk NN cord-010092-uftc8inx 10172 17 for for IN cord-010092-uftc8inx 10172 18 forming form VBG cord-010092-uftc8inx 10172 19 allo allo NNP cord-010092-uftc8inx 10172 20 anti anti JJ cord-010092-uftc8inx 10172 21 - - JJ cord-010092-uftc8inx 10172 22 D d JJ cord-010092-uftc8inx 10172 23 when when WRB cord-010092-uftc8inx 10172 24 exposed expose VBN cord-010092-uftc8inx 10172 25 to to IN cord-010092-uftc8inx 10172 26 conventional conventional JJ cord-010092-uftc8inx 10172 27 Rh Rh NNP cord-010092-uftc8inx 10172 28 D d NN cord-010092-uftc8inx 10172 29 - - HYPH cord-010092-uftc8inx 10172 30 positive positive JJ cord-010092-uftc8inx 10172 31 RBCs rbc NNS cord-010092-uftc8inx 10172 32 . . . cord-010092-uftc8inx 10173 1 Molecular molecular JJ cord-010092-uftc8inx 10173 2 analysis analysis NN cord-010092-uftc8inx 10173 3 of of IN cord-010092-uftc8inx 10173 4 weak weak JJ cord-010092-uftc8inx 10173 5 D D NNP cord-010092-uftc8inx 10173 6 offers offer VBZ cord-010092-uftc8inx 10173 7 a a DT cord-010092-uftc8inx 10173 8 more more RBR cord-010092-uftc8inx 10173 9 reliable reliable JJ cord-010092-uftc8inx 10173 10 basis basis NN cord-010092-uftc8inx 10173 11 than than IN cord-010092-uftc8inx 10173 12 serotyping serotype VBG cord-010092-uftc8inx 10173 13 to to TO cord-010092-uftc8inx 10173 14 determine determine VB cord-010092-uftc8inx 10173 15 the the DT cord-010092-uftc8inx 10173 16 prevalence prevalence NN cord-010092-uftc8inx 10173 17 of of IN cord-010092-uftc8inx 10173 18 weak weak JJ cord-010092-uftc8inx 10173 19 D d NN cord-010092-uftc8inx 10173 20 types type NNS cord-010092-uftc8inx 10173 21 and and CC cord-010092-uftc8inx 10173 22 optimal optimal JJ cord-010092-uftc8inx 10173 23 D d NN cord-010092-uftc8inx 10173 24 transfusion transfusion NN cord-010092-uftc8inx 10173 25 strategies strategy NNS cord-010092-uftc8inx 10173 26 . . . cord-010092-uftc8inx 10174 1 Background background NN cord-010092-uftc8inx 10174 2 : : : cord-010092-uftc8inx 10175 1 The the DT cord-010092-uftc8inx 10175 2 D d NN cord-010092-uftc8inx 10175 3 antigen antigen NN cord-010092-uftc8inx 10175 4 , , , cord-010092-uftc8inx 10175 5 which which WDT cord-010092-uftc8inx 10175 6 consists consist VBZ cord-010092-uftc8inx 10175 7 of of IN cord-010092-uftc8inx 10175 8 a a DT cord-010092-uftc8inx 10175 9 mosaic mosaic NN cord-010092-uftc8inx 10175 10 of of IN cord-010092-uftc8inx 10175 11 epitopes epitope NNS cord-010092-uftc8inx 10175 12 , , , cord-010092-uftc8inx 10175 13 is be VBZ cord-010092-uftc8inx 10175 14 determined determine VBN cord-010092-uftc8inx 10175 15 in in IN cord-010092-uftc8inx 10175 16 all all PDT cord-010092-uftc8inx 10175 17 the the DT cord-010092-uftc8inx 10175 18 blood blood NN cord-010092-uftc8inx 10175 19 donors donor NNS cord-010092-uftc8inx 10175 20 and and CC cord-010092-uftc8inx 10175 21 patients patient NNS cord-010092-uftc8inx 10175 22 . . . cord-010092-uftc8inx 10176 1 Most Most JJS cord-010092-uftc8inx 10176 2 people people NNS cord-010092-uftc8inx 10176 3 are be VBP cord-010092-uftc8inx 10176 4 either either RB cord-010092-uftc8inx 10176 5 RhD rhd NN cord-010092-uftc8inx 10176 6 - - HYPH cord-010092-uftc8inx 10176 7 positive positive JJ cord-010092-uftc8inx 10176 8 or or CC cord-010092-uftc8inx 10176 9 RhDnegative rhdnegative JJ cord-010092-uftc8inx 10176 10 , , , cord-010092-uftc8inx 10176 11 but but CC cord-010092-uftc8inx 10176 12 there there EX cord-010092-uftc8inx 10176 13 is be VBZ cord-010092-uftc8inx 10176 14 a a DT cord-010092-uftc8inx 10176 15 certain certain JJ cord-010092-uftc8inx 10176 16 number number NN cord-010092-uftc8inx 10176 17 of of IN cord-010092-uftc8inx 10176 18 people people NNS cord-010092-uftc8inx 10176 19 who who WP cord-010092-uftc8inx 10176 20 have have VBP cord-010092-uftc8inx 10176 21 a a DT cord-010092-uftc8inx 10176 22 variation variation NN cord-010092-uftc8inx 10176 23 of of IN cord-010092-uftc8inx 10176 24 the the DT cord-010092-uftc8inx 10176 25 D D NNP cord-010092-uftc8inx 10176 26 antigen antigen NN cord-010092-uftc8inx 10176 27 , , , cord-010092-uftc8inx 10176 28 which which WDT cord-010092-uftc8inx 10176 29 are be VBP cord-010092-uftc8inx 10176 30 called call VBN cord-010092-uftc8inx 10176 31 weak weak JJ cord-010092-uftc8inx 10176 32 D D NNP cord-010092-uftc8inx 10176 33 , , , cord-010092-uftc8inx 10176 34 partial partial JJ cord-010092-uftc8inx 10176 35 D d NN cord-010092-uftc8inx 10176 36 and and CC cord-010092-uftc8inx 10176 37 DEL DEL NNP cord-010092-uftc8inx 10176 38 phenotypes phenotype NNS cord-010092-uftc8inx 10176 39 . . . cord-010092-uftc8inx 10177 1 Aims aim VBZ cord-010092-uftc8inx 10177 2 : : : cord-010092-uftc8inx 10178 1 The the DT cord-010092-uftc8inx 10178 2 objective objective NN cord-010092-uftc8inx 10178 3 is be VBZ cord-010092-uftc8inx 10178 4 to to TO cord-010092-uftc8inx 10178 5 use use VB cord-010092-uftc8inx 10178 6 molecular molecular JJ cord-010092-uftc8inx 10178 7 methods method NNS cord-010092-uftc8inx 10178 8 to to TO cord-010092-uftc8inx 10178 9 determine determine VB cord-010092-uftc8inx 10178 10 whether whether IN cord-010092-uftc8inx 10178 11 blood blood NN cord-010092-uftc8inx 10178 12 donors donor NNS cord-010092-uftc8inx 10178 13 in in IN cord-010092-uftc8inx 10178 14 Republika Republika NNP cord-010092-uftc8inx 10178 15 Srpska Srpska NNP cord-010092-uftc8inx 10178 16 ( ( -LRB- cord-010092-uftc8inx 10178 17 with with IN cord-010092-uftc8inx 10178 18 whom whom WP cord-010092-uftc8inx 10178 19 a a DT cord-010092-uftc8inx 10178 20 serological serological JJ cord-010092-uftc8inx 10178 21 weak weak JJ cord-010092-uftc8inx 10178 22 D d NN cord-010092-uftc8inx 10178 23 antigen antigen NN cord-010092-uftc8inx 10178 24 has have VBZ cord-010092-uftc8inx 10178 25 been be VBN cord-010092-uftc8inx 10178 26 detected detect VBN cord-010092-uftc8inx 10178 27 ) ) -RRB- cord-010092-uftc8inx 10178 28 really really RB cord-010092-uftc8inx 10178 29 have have VB cord-010092-uftc8inx 10178 30 the the DT cord-010092-uftc8inx 10178 31 weak weak JJ cord-010092-uftc8inx 10178 32 D D NNP cord-010092-uftc8inx 10178 33 antigen antigen NN cord-010092-uftc8inx 10178 34 . . . cord-010092-uftc8inx 10179 1 In in IN cord-010092-uftc8inx 10179 2 addition addition NN cord-010092-uftc8inx 10179 3 , , , cord-010092-uftc8inx 10179 4 determine determine VB cord-010092-uftc8inx 10179 5 whether whether IN cord-010092-uftc8inx 10179 6 blood blood NN cord-010092-uftc8inx 10179 7 donors donor NNS cord-010092-uftc8inx 10179 8 , , , cord-010092-uftc8inx 10179 9 who who WP cord-010092-uftc8inx 10179 10 have have VBP cord-010092-uftc8inx 10179 11 been be VBN cord-010092-uftc8inx 10179 12 determined determine VBN cord-010092-uftc8inx 10179 13 as as IN cord-010092-uftc8inx 10179 14 persons person NNS cord-010092-uftc8inx 10179 15 who who WP cord-010092-uftc8inx 10179 16 are be VBP cord-010092-uftc8inx 10179 17 RhD rhd NN cord-010092-uftc8inx 10179 18 - - HYPH cord-010092-uftc8inx 10179 19 negative negative JJ cord-010092-uftc8inx 10179 20 , , , cord-010092-uftc8inx 10179 21 with with IN cord-010092-uftc8inx 10179 22 the the DT cord-010092-uftc8inx 10179 23 phenotypes phenotype NNS cord-010092-uftc8inx 10180 1 C C NNP cord-010092-uftc8inx 10180 2 and/ and/ NNP cord-010092-uftc8inx 10181 1 or or CC cord-010092-uftc8inx 10181 2 E E NNP cord-010092-uftc8inx 10181 3 , , , cord-010092-uftc8inx 10181 4 who who WP cord-010092-uftc8inx 10181 5 have have VBP cord-010092-uftc8inx 10181 6 the the DT cord-010092-uftc8inx 10181 7 RHD RHD NNP cord-010092-uftc8inx 10181 8 gene gene NN cord-010092-uftc8inx 10181 9 and and CC cord-010092-uftc8inx 10181 10 D d NN cord-010092-uftc8inx 10181 11 antigen antigen NN cord-010092-uftc8inx 10181 12 on on IN cord-010092-uftc8inx 10181 13 the the DT cord-010092-uftc8inx 10181 14 erythrocyte erythrocyte NN cord-010092-uftc8inx 10181 15 membrane membrane NN cord-010092-uftc8inx 10181 16 , , , cord-010092-uftc8inx 10181 17 so so RB cord-010092-uftc8inx 10181 18 weak weak JJ cord-010092-uftc8inx 10181 19 that that IN cord-010092-uftc8inx 10181 20 it -PRON- PRP cord-010092-uftc8inx 10181 21 could could MD cord-010092-uftc8inx 10181 22 not not RB cord-010092-uftc8inx 10181 23 be be VB cord-010092-uftc8inx 10181 24 determined determine VBN cord-010092-uftc8inx 10181 25 by by IN cord-010092-uftc8inx 10181 26 serological serological JJ cord-010092-uftc8inx 10181 27 techniques technique NNS cord-010092-uftc8inx 10181 28 . . . cord-010092-uftc8inx 10182 1 Methods method NNS cord-010092-uftc8inx 10182 2 : : : cord-010092-uftc8inx 10182 3 Blood blood NN cord-010092-uftc8inx 10182 4 samples sample NNS cord-010092-uftc8inx 10182 5 were be VBD cord-010092-uftc8inx 10182 6 used use VBN cord-010092-uftc8inx 10182 7 from from IN cord-010092-uftc8inx 10182 8 regular regular JJ cord-010092-uftc8inx 10182 9 blood blood NN cord-010092-uftc8inx 10182 10 donors donor NNS cord-010092-uftc8inx 10182 11 , , , cord-010092-uftc8inx 10182 12 who who WP cord-010092-uftc8inx 10182 13 have have VBP cord-010092-uftc8inx 10182 14 been be VBN cord-010092-uftc8inx 10182 15 determined determine VBN cord-010092-uftc8inx 10182 16 as as IN cord-010092-uftc8inx 10182 17 persons person NNS cord-010092-uftc8inx 10182 18 with with IN cord-010092-uftc8inx 10182 19 a a DT cord-010092-uftc8inx 10182 20 weaker weak JJR cord-010092-uftc8inx 10182 21 D d NN cord-010092-uftc8inx 10182 22 antigen antigen NN cord-010092-uftc8inx 10182 23 , , , cord-010092-uftc8inx 10182 24 as as IN cord-010092-uftc8inx 10182 25 RhD rhd NN cord-010092-uftc8inx 10182 26 - - HYPH cord-010092-uftc8inx 10182 27 negative negative JJ cord-010092-uftc8inx 10182 28 or or CC cord-010092-uftc8inx 10182 29 as as IN cord-010092-uftc8inx 10182 30 C C NNP cord-010092-uftc8inx 10183 1 and/or and/or CC cord-010092-uftc8inx 10183 2 E e LS cord-010092-uftc8inx 10183 3 positive positive JJ cord-010092-uftc8inx 10183 4 ( ( -LRB- cord-010092-uftc8inx 10183 5 based base VBN cord-010092-uftc8inx 10183 6 on on IN cord-010092-uftc8inx 10183 7 the the DT cord-010092-uftc8inx 10183 8 agglutination agglutination NN cord-010092-uftc8inx 10183 9 strength strength NN cord-010092-uftc8inx 10183 10 ) ) -RRB- cord-010092-uftc8inx 10184 1 using use VBG cord-010092-uftc8inx 10184 2 serological serological JJ cord-010092-uftc8inx 10184 3 techniques technique NNS cord-010092-uftc8inx 10184 4 , , , cord-010092-uftc8inx 10184 5 the the DT cord-010092-uftc8inx 10184 6 test test NN cord-010092-uftc8inx 10184 7 tube tube NN cord-010092-uftc8inx 10184 8 method method NN cord-010092-uftc8inx 10184 9 , , , cord-010092-uftc8inx 10184 10 the the DT cord-010092-uftc8inx 10184 11 microplate microplate NN cord-010092-uftc8inx 10184 12 method method NN cord-010092-uftc8inx 10184 13 and and CC cord-010092-uftc8inx 10184 14 the the DT cord-010092-uftc8inx 10184 15 gel gel NN cord-010092-uftc8inx 10184 16 method method NN cord-010092-uftc8inx 10184 17 . . . cord-010092-uftc8inx 10185 1 GP.Mur GP.Mur NNP cord-010092-uftc8inx 10185 2 was be VBD cord-010092-uftc8inx 10185 3 also also RB cord-010092-uftc8inx 10185 4 modelled model VBN cord-010092-uftc8inx 10185 5 and and CC cord-010092-uftc8inx 10185 6 shown show VBN cord-010092-uftc8inx 10185 7 to to TO cord-010092-uftc8inx 10185 8 closely closely RB cord-010092-uftc8inx 10185 9 resemble resemble VB cord-010092-uftc8inx 10185 10 the the DT cord-010092-uftc8inx 10185 11 tertiary tertiary JJ cord-010092-uftc8inx 10185 12 structure structure NN cord-010092-uftc8inx 10185 13 of of IN cord-010092-uftc8inx 10185 14 glycophorin glycophorin NNP cord-010092-uftc8inx 10185 15 A. a. NN cord-010092-uftc8inx 10186 1 The the DT cord-010092-uftc8inx 10186 2 predicted predict VBN cord-010092-uftc8inx 10186 3 structure structure NN cord-010092-uftc8inx 10186 4 is be VBZ cord-010092-uftc8inx 10186 5 5 5 CD cord-010092-uftc8inx 10186 6 anti anti JJ cord-010092-uftc8inx 10186 7 - - JJ cord-010092-uftc8inx 10186 8 parallel parallel JJ cord-010092-uftc8inx 10186 9 b b NN cord-010092-uftc8inx 10186 10 sheets sheet NNS cord-010092-uftc8inx 10186 11 arranged arrange VBN cord-010092-uftc8inx 10186 12 in in IN cord-010092-uftc8inx 10186 13 a a DT cord-010092-uftc8inx 10186 14 " " `` cord-010092-uftc8inx 10186 15 b b NN cord-010092-uftc8inx 10186 16 barrel barrel NN cord-010092-uftc8inx 10186 17 " " '' cord-010092-uftc8inx 10186 18 also also RB cord-010092-uftc8inx 10186 19 referred refer VBD cord-010092-uftc8inx 10186 20 to to IN cord-010092-uftc8inx 10186 21 as as IN cord-010092-uftc8inx 10186 22 an an DT cord-010092-uftc8inx 10186 23 OB OB NNP cord-010092-uftc8inx 10186 24 - - HYPH cord-010092-uftc8inx 10186 25 like like JJ cord-010092-uftc8inx 10186 26 - - HYPH cord-010092-uftc8inx 10186 27 fold fold NN cord-010092-uftc8inx 10186 28 . . . cord-010092-uftc8inx 10187 1 The the DT cord-010092-uftc8inx 10187 2 regions region NNS cord-010092-uftc8inx 10187 3 in in IN cord-010092-uftc8inx 10187 4 which which WDT cord-010092-uftc8inx 10187 5 blood blood NN cord-010092-uftc8inx 10187 6 group group NN cord-010092-uftc8inx 10187 7 antigens antigen NNS cord-010092-uftc8inx 10187 8 were be VBD cord-010092-uftc8inx 10187 9 identified identify VBN cord-010092-uftc8inx 10187 10 in in IN cord-010092-uftc8inx 10187 11 the the DT cord-010092-uftc8inx 10187 12 predicted predict VBN cord-010092-uftc8inx 10187 13 stable stable JJ cord-010092-uftc8inx 10187 14 dimeric dimeric JJ cord-010092-uftc8inx 10187 15 structure structure NN cord-010092-uftc8inx 10187 16 . . . cord-010092-uftc8inx 10188 1 Summary Summary NNP cord-010092-uftc8inx 10188 2 / / SYM cord-010092-uftc8inx 10188 3 Conclusions conclusion NNS cord-010092-uftc8inx 10188 4 : : : cord-010092-uftc8inx 10188 5 OB OB NNP cord-010092-uftc8inx 10188 6 - - HYPH cord-010092-uftc8inx 10188 7 like like JJ cord-010092-uftc8inx 10188 8 - - HYPH cord-010092-uftc8inx 10188 9 fold fold VB cord-010092-uftc8inx 10188 10 structures structure NNS cord-010092-uftc8inx 10188 11 typically typically RB cord-010092-uftc8inx 10188 12 to to TO cord-010092-uftc8inx 10188 13 bind bind VB cord-010092-uftc8inx 10188 14 oligonucleotides oligonucleotide NNS cord-010092-uftc8inx 10188 15 or or CC cord-010092-uftc8inx 10188 16 oligosaccharides oligosaccharide NNS cord-010092-uftc8inx 10188 17 and and CC cord-010092-uftc8inx 10188 18 are be VBP cord-010092-uftc8inx 10188 19 associated associate VBN cord-010092-uftc8inx 10188 20 with with IN cord-010092-uftc8inx 10188 21 cold cold JJ cord-010092-uftc8inx 10188 22 shock shock NN cord-010092-uftc8inx 10188 23 proteins protein NNS cord-010092-uftc8inx 10188 24 . . . cord-010092-uftc8inx 10189 1 Further further JJ cord-010092-uftc8inx 10189 2 modelling modelling NN cord-010092-uftc8inx 10189 3 is be VBZ cord-010092-uftc8inx 10189 4 in in IN cord-010092-uftc8inx 10189 5 progress progress NN cord-010092-uftc8inx 10189 6 to to TO cord-010092-uftc8inx 10189 7 predict predict VB cord-010092-uftc8inx 10189 8 the the DT cord-010092-uftc8inx 10189 9 structure structure NN cord-010092-uftc8inx 10189 10 of of IN cord-010092-uftc8inx 10189 11 GPA GPA NNP cord-010092-uftc8inx 10189 12 / / SYM cord-010092-uftc8inx 10189 13 GPB GPB NNP cord-010092-uftc8inx 10189 14 heterodimers heterodimer NNS cord-010092-uftc8inx 10189 15 as as IN cord-010092-uftc8inx 10189 16 a a DT cord-010092-uftc8inx 10189 17 basis basis NN cord-010092-uftc8inx 10189 18 for for IN cord-010092-uftc8inx 10189 19 understanding understand VBG cord-010092-uftc8inx 10189 20 the the DT cord-010092-uftc8inx 10189 21 presentation presentation NN cord-010092-uftc8inx 10189 22 of of IN cord-010092-uftc8inx 10189 23 blood blood NN cord-010092-uftc8inx 10189 24 group group NN cord-010092-uftc8inx 10189 25 antigens antigen NNS cord-010092-uftc8inx 10189 26 . . . cord-010092-uftc8inx 10190 1 Of of IN cord-010092-uftc8inx 10190 2 interest interest NN cord-010092-uftc8inx 10190 3 , , , cord-010092-uftc8inx 10190 4 this this DT cord-010092-uftc8inx 10190 5 finding finding NN cord-010092-uftc8inx 10190 6 is be VBZ cord-010092-uftc8inx 10190 7 consistent consistent JJ cord-010092-uftc8inx 10190 8 with with IN cord-010092-uftc8inx 10190 9 a a DT cord-010092-uftc8inx 10190 10 previous previous JJ cord-010092-uftc8inx 10190 11 report report NN cord-010092-uftc8inx 10190 12 showing show VBG cord-010092-uftc8inx 10190 13 that that IN cord-010092-uftc8inx 10190 14 this this DT cord-010092-uftc8inx 10190 15 GPA GPA NNP cord-010092-uftc8inx 10190 16 binds bind VBZ cord-010092-uftc8inx 10190 17 to to IN cord-010092-uftc8inx 10190 18 carbohydrates carbohydrate NNS cord-010092-uftc8inx 10190 19 . . . cord-010092-uftc8inx 10191 1 This this DT cord-010092-uftc8inx 10191 2 model model NN cord-010092-uftc8inx 10191 3 serves serve VBZ cord-010092-uftc8inx 10191 4 as as IN cord-010092-uftc8inx 10191 5 a a DT cord-010092-uftc8inx 10191 6 foundation foundation NN cord-010092-uftc8inx 10191 7 for for IN cord-010092-uftc8inx 10191 8 future future JJ cord-010092-uftc8inx 10191 9 work work NN cord-010092-uftc8inx 10191 10 regarding regard VBG cord-010092-uftc8inx 10191 11 the the DT cord-010092-uftc8inx 10191 12 properties property NNS cord-010092-uftc8inx 10191 13 of of IN cord-010092-uftc8inx 10191 14 GPA GPA NNP cord-010092-uftc8inx 10191 15 , , , cord-010092-uftc8inx 10191 16 which which WDT cord-010092-uftc8inx 10191 17 includes include VBZ cord-010092-uftc8inx 10191 18 identifying identify VBG cord-010092-uftc8inx 10191 19 locations location NNS cord-010092-uftc8inx 10191 20 of of IN cord-010092-uftc8inx 10191 21 specific specific JJ cord-010092-uftc8inx 10191 22 interactions interaction NNS cord-010092-uftc8inx 10191 23 between between IN cord-010092-uftc8inx 10191 24 GPA GPA NNP cord-010092-uftc8inx 10191 25 and and CC cord-010092-uftc8inx 10191 26 other other JJ cord-010092-uftc8inx 10191 27 RBC RBC NNP cord-010092-uftc8inx 10191 28 surface surface NN cord-010092-uftc8inx 10191 29 proteins protein NNS cord-010092-uftc8inx 10191 30 such such JJ cord-010092-uftc8inx 10191 31 as as IN cord-010092-uftc8inx 10191 32 GPB GPB NNP cord-010092-uftc8inx 10191 33 and and CC cord-010092-uftc8inx 10191 34 Band Band NNP cord-010092-uftc8inx 10191 35 3 3 CD cord-010092-uftc8inx 10191 36 , , , cord-010092-uftc8inx 10191 37 as as RB cord-010092-uftc8inx 10191 38 well well RB cord-010092-uftc8inx 10191 39 as as IN cord-010092-uftc8inx 10191 40 identifying identify VBG cord-010092-uftc8inx 10191 41 structural structural JJ cord-010092-uftc8inx 10191 42 features feature NNS cord-010092-uftc8inx 10191 43 of of IN cord-010092-uftc8inx 10191 44 antigenic antigenic JJ cord-010092-uftc8inx 10191 45 regions region NNS cord-010092-uftc8inx 10191 46 on on IN cord-010092-uftc8inx 10191 47 GPA GPA NNP cord-010092-uftc8inx 10191 48 . . . cord-010092-uftc8inx 10191 49 . . . cord-010092-uftc8inx 10192 1 Even even RB cord-010092-uftc8inx 10192 2 though though IN cord-010092-uftc8inx 10192 3 no no DT cord-010092-uftc8inx 10192 4 significant significant JJ cord-010092-uftc8inx 10192 5 differences difference NNS cord-010092-uftc8inx 10192 6 were be VBD cord-010092-uftc8inx 10192 7 found find VBN cord-010092-uftc8inx 10192 8 among among IN cord-010092-uftc8inx 10192 9 the the DT cord-010092-uftc8inx 10192 10 groups group NNS cord-010092-uftc8inx 10192 11 studied study VBD cord-010092-uftc8inx 10192 12 , , , cord-010092-uftc8inx 10192 13 4 4 CD cord-010092-uftc8inx 10192 14 haplotypes haplotype NNS cord-010092-uftc8inx 10192 15 containing contain VBG cord-010092-uftc8inx 10192 16 the the DT cord-010092-uftc8inx 10192 17 McC McC NNP cord-010092-uftc8inx 10192 18 b b NNP cord-010092-uftc8inx 10192 19 and and CC cord-010092-uftc8inx 10192 20 SL2 SL2 NNP cord-010092-uftc8inx 10192 21 polymorphisms polymorphism NNS cord-010092-uftc8inx 10192 22 were be VBD cord-010092-uftc8inx 10192 23 identified identify VBN cord-010092-uftc8inx 10192 24 in in IN cord-010092-uftc8inx 10192 25 D d NN cord-010092-uftc8inx 10192 26 samples sample NNS cord-010092-uftc8inx 10192 27 but but CC cord-010092-uftc8inx 10192 28 were be VBD cord-010092-uftc8inx 10192 29 not not RB cord-010092-uftc8inx 10192 30 found find VBN cord-010092-uftc8inx 10192 31 in in IN cord-010092-uftc8inx 10192 32 TB TB NNP cord-010092-uftc8inx 10192 33 and and CC cord-010092-uftc8inx 10192 34 L L NNP cord-010092-uftc8inx 10192 35 groups group NNS cord-010092-uftc8inx 10192 36 . . . cord-010092-uftc8inx 10193 1 Summary Summary NNP cord-010092-uftc8inx 10193 2 / / SYM cord-010092-uftc8inx 10193 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 10193 4 : : : cord-010092-uftc8inx 10194 1 This this DT cord-010092-uftc8inx 10194 2 preliminary preliminary JJ cord-010092-uftc8inx 10194 3 data datum NNS cord-010092-uftc8inx 10194 4 obtained obtain VBD cord-010092-uftc8inx 10194 5 suggests suggest VBZ cord-010092-uftc8inx 10194 6 that that IN cord-010092-uftc8inx 10194 7 CR1 CR1 NNP cord-010092-uftc8inx 10194 8 polymorphisms polymorphism NNS cord-010092-uftc8inx 10194 9 and and CC cord-010092-uftc8inx 10194 10 haplotypes haplotype NNS cord-010092-uftc8inx 10194 11 , , , cord-010092-uftc8inx 10194 12 especially especially RB cord-010092-uftc8inx 10194 13 those those DT cord-010092-uftc8inx 10194 14 containing contain VBG cord-010092-uftc8inx 10194 15 McC McC NNP cord-010092-uftc8inx 10194 16 b b NNP cord-010092-uftc8inx 10194 17 and and CC cord-010092-uftc8inx 10194 18 Sl2 Sl2 NNP cord-010092-uftc8inx 10194 19 SNPs SNPs NNPS cord-010092-uftc8inx 10194 20 , , , cord-010092-uftc8inx 10194 21 could could MD cord-010092-uftc8inx 10194 22 be be VB cord-010092-uftc8inx 10194 23 involved involve VBN cord-010092-uftc8inx 10194 24 in in IN cord-010092-uftc8inx 10194 25 the the DT cord-010092-uftc8inx 10194 26 disease disease NN cord-010092-uftc8inx 10194 27 pathogenesis pathogenesis NN cord-010092-uftc8inx 10194 28 of of IN cord-010092-uftc8inx 10194 29 tuberculosis tuberculosis NN cord-010092-uftc8inx 10194 30 and and CC cord-010092-uftc8inx 10194 31 leprosy leprosy NN cord-010092-uftc8inx 10194 32 . . . cord-010092-uftc8inx 10195 1 The the DT cord-010092-uftc8inx 10195 2 entrance entrance NN cord-010092-uftc8inx 10195 3 of of IN cord-010092-uftc8inx 10195 4 mycobacteria mycobacterium NNS cord-010092-uftc8inx 10195 5 into into IN cord-010092-uftc8inx 10195 6 macrophages macrophage NNS cord-010092-uftc8inx 10195 7 is be VBZ cord-010092-uftc8inx 10195 8 mediated mediate VBN cord-010092-uftc8inx 10195 9 by by IN cord-010092-uftc8inx 10195 10 complement complement JJ cord-010092-uftc8inx 10195 11 receptors receptor NNS cord-010092-uftc8inx 10195 12 that that WDT cord-010092-uftc8inx 10195 13 facilitate facilitate VBP cord-010092-uftc8inx 10195 14 their -PRON- PRP$ cord-010092-uftc8inx 10195 15 uptake uptake NN cord-010092-uftc8inx 10195 16 by by IN cord-010092-uftc8inx 10195 17 host host NN cord-010092-uftc8inx 10195 18 cells cell NNS cord-010092-uftc8inx 10195 19 so so IN cord-010092-uftc8inx 10195 20 the the DT cord-010092-uftc8inx 10195 21 combined combined JJ cord-010092-uftc8inx 10195 22 haplotypes haplotype NNS cord-010092-uftc8inx 10195 23 could could MD cord-010092-uftc8inx 10195 24 be be VB cord-010092-uftc8inx 10195 25 enhancing enhance VBG cord-010092-uftc8inx 10195 26 parasite parasite NN cord-010092-uftc8inx 10195 27 phagocytosis phagocytosis NN cord-010092-uftc8inx 10195 28 and and CC cord-010092-uftc8inx 10195 29 inflammation inflammation NN cord-010092-uftc8inx 10195 30 . . . cord-010092-uftc8inx 10196 1 Further further JJ cord-010092-uftc8inx 10196 2 studies study NNS cord-010092-uftc8inx 10196 3 are be VBP cord-010092-uftc8inx 10196 4 being be VBG cord-010092-uftc8inx 10196 5 carried carry VBN cord-010092-uftc8inx 10196 6 out out RP cord-010092-uftc8inx 10196 7 to to TO cord-010092-uftc8inx 10196 8 establish establish VB cord-010092-uftc8inx 10196 9 whether whether IN cord-010092-uftc8inx 10196 10 CR1 CR1 NNP cord-010092-uftc8inx 10196 11 polymorphisms polymorphism NNS cord-010092-uftc8inx 10196 12 are be VBP cord-010092-uftc8inx 10196 13 risk risk NN cord-010092-uftc8inx 10196 14 or or CC cord-010092-uftc8inx 10196 15 protective protective JJ cord-010092-uftc8inx 10196 16 factors factor NNS cord-010092-uftc8inx 10196 17 and and CC cord-010092-uftc8inx 10196 18 whether whether IN cord-010092-uftc8inx 10196 19 other other JJ cord-010092-uftc8inx 10196 20 genetic genetic JJ cord-010092-uftc8inx 10196 21 variations variation NNS cord-010092-uftc8inx 10196 22 in in IN cord-010092-uftc8inx 10196 23 this this DT cord-010092-uftc8inx 10196 24 receptor receptor NN cord-010092-uftc8inx 10196 25 are be VBP cord-010092-uftc8inx 10196 26 also also RB cord-010092-uftc8inx 10196 27 involved involve VBN cord-010092-uftc8inx 10196 28 . . . cord-010092-uftc8inx 10197 1 Abstract Abstract NNP cord-010092-uftc8inx 10197 2 withdrawn withdraw VBN cord-010092-uftc8inx 10197 3 . . . cord-010092-uftc8inx 10198 1 Background background NN cord-010092-uftc8inx 10198 2 : : : cord-010092-uftc8inx 10199 1 The the DT cord-010092-uftc8inx 10199 2 Dombrock Dombrock NNP cord-010092-uftc8inx 10199 3 blood blood NN cord-010092-uftc8inx 10199 4 group group NN cord-010092-uftc8inx 10199 5 system system NN cord-010092-uftc8inx 10199 6 consists consist VBZ cord-010092-uftc8inx 10199 7 of of IN cord-010092-uftc8inx 10199 8 two two CD cord-010092-uftc8inx 10199 9 antithetical antithetical JJ cord-010092-uftc8inx 10199 10 antigens antigen NNS cord-010092-uftc8inx 10199 11 , , , cord-010092-uftc8inx 10199 12 Do do VB cord-010092-uftc8inx 10199 13 a a DT cord-010092-uftc8inx 10199 14 and and CC cord-010092-uftc8inx 10199 15 Do do VBP cord-010092-uftc8inx 10199 16 b b NN cord-010092-uftc8inx 10199 17 , , , cord-010092-uftc8inx 10199 18 and and CC cord-010092-uftc8inx 10199 19 three three CD cord-010092-uftc8inx 10199 20 high high JJ cord-010092-uftc8inx 10199 21 - - HYPH cord-010092-uftc8inx 10199 22 prevalence prevalence NN cord-010092-uftc8inx 10199 23 antigens antigen NNS cord-010092-uftc8inx 10199 24 , , , cord-010092-uftc8inx 10199 25 Gregory Gregory NNP cord-010092-uftc8inx 10199 26 ( ( -LRB- cord-010092-uftc8inx 10199 27 Gy Gy NNP cord-010092-uftc8inx 10199 28 a a DT cord-010092-uftc8inx 10199 29 ) ) -RRB- cord-010092-uftc8inx 10199 30 , , , cord-010092-uftc8inx 10199 31 Holley Holley NNP cord-010092-uftc8inx 10199 32 ( ( -LRB- cord-010092-uftc8inx 10199 33 Hy Hy NNP cord-010092-uftc8inx 10199 34 ) ) -RRB- cord-010092-uftc8inx 10199 35 , , , cord-010092-uftc8inx 10199 36 and and CC cord-010092-uftc8inx 10199 37 Joseph Joseph NNP cord-010092-uftc8inx 10199 38 ( ( -LRB- cord-010092-uftc8inx 10199 39 Jo Jo NNP cord-010092-uftc8inx 10199 40 a a NNP cord-010092-uftc8inx 10199 41 ) ) -RRB- cord-010092-uftc8inx 10199 42 . . . cord-010092-uftc8inx 10200 1 The the DT cord-010092-uftc8inx 10201 1 rare rare JJ cord-010092-uftc8inx 10201 2 Do do VBP cord-010092-uftc8inx 10201 3 null null NN cord-010092-uftc8inx 10201 4 or or CC cord-010092-uftc8inx 10201 5 Gy(a- gy(a- CD cord-010092-uftc8inx 10201 6 ) ) -RRB- cord-010092-uftc8inx 10202 1 phenotype phenotype NN cord-010092-uftc8inx 10202 2 lacks lack VBZ cord-010092-uftc8inx 10202 3 all all DT cord-010092-uftc8inx 10202 4 Dombrock Dombrock NNP cord-010092-uftc8inx 10202 5 antigens antigen NNS cord-010092-uftc8inx 10202 6 , , , cord-010092-uftc8inx 10202 7 and and CC cord-010092-uftc8inx 10202 8 the the DT cord-010092-uftc8inx 10202 9 DO DO NNP cord-010092-uftc8inx 10202 10 null null JJ cord-010092-uftc8inx 10202 11 alleles allele NNS cord-010092-uftc8inx 10202 12 vary vary VBP cord-010092-uftc8inx 10202 13 with with IN cord-010092-uftc8inx 10202 14 both both DT cord-010092-uftc8inx 10202 15 DO*01 DO*01 NNS cord-010092-uftc8inx 10202 16 and and CC cord-010092-uftc8inx 10202 17 DO*02 do*02 NN cord-010092-uftc8inx 10202 18 backgrounds background NNS cord-010092-uftc8inx 10202 19 . . . cord-010092-uftc8inx 10203 1 Here here RB cord-010092-uftc8inx 10203 2 we -PRON- PRP cord-010092-uftc8inx 10203 3 report report VBP cord-010092-uftc8inx 10203 4 the the DT cord-010092-uftc8inx 10203 5 molecular molecular JJ cord-010092-uftc8inx 10203 6 basis basis NN cord-010092-uftc8inx 10203 7 of of IN cord-010092-uftc8inx 10203 8 a a DT cord-010092-uftc8inx 10203 9 novel novel NN cord-010092-uftc8inx 10203 10 DO do VB cord-010092-uftc8inx 10203 11 null null JJ cord-010092-uftc8inx 10203 12 allele allele NN cord-010092-uftc8inx 10203 13 in in IN cord-010092-uftc8inx 10203 14 a a DT cord-010092-uftc8inx 10203 15 Gy(a- gy(a- CD cord-010092-uftc8inx 10203 16 ) ) -RRB- cord-010092-uftc8inx 10204 1 Brazilian brazilian JJ cord-010092-uftc8inx 10204 2 patient patient NN cord-010092-uftc8inx 10204 3 with with IN cord-010092-uftc8inx 10204 4 anti anti JJ cord-010092-uftc8inx 10204 5 - - NNP cord-010092-uftc8inx 10204 6 Gy Gy NNP cord-010092-uftc8inx 10204 7 a a NN cord-010092-uftc8inx 10204 8 . . . cord-010092-uftc8inx 10205 1 Aims aim VBZ cord-010092-uftc8inx 10205 2 : : : cord-010092-uftc8inx 10206 1 Case case NN cord-010092-uftc8inx 10206 2 presentation presentation NN cord-010092-uftc8inx 10206 3 : : : cord-010092-uftc8inx 10206 4 An an DT cord-010092-uftc8inx 10206 5 alloantibody alloantibody NN cord-010092-uftc8inx 10206 6 to to IN cord-010092-uftc8inx 10206 7 a a DT cord-010092-uftc8inx 10206 8 high high JJ cord-010092-uftc8inx 10206 9 - - HYPH cord-010092-uftc8inx 10206 10 prevalence prevalence NN cord-010092-uftc8inx 10206 11 antigen antigen NN cord-010092-uftc8inx 10206 12 was be VBD cord-010092-uftc8inx 10206 13 detected detect VBN cord-010092-uftc8inx 10206 14 in in IN cord-010092-uftc8inx 10206 15 the the DT cord-010092-uftc8inx 10206 16 serum serum NN cord-010092-uftc8inx 10206 17 of of IN cord-010092-uftc8inx 10206 18 a a DT cord-010092-uftc8inx 10206 19 42 42 CD cord-010092-uftc8inx 10206 20 year year NN cord-010092-uftc8inx 10206 21 old old JJ cord-010092-uftc8inx 10206 22 woman woman NN cord-010092-uftc8inx 10206 23 from from IN cord-010092-uftc8inx 10206 24 the the DT cord-010092-uftc8inx 10206 25 Northeast Northeast NNP cord-010092-uftc8inx 10206 26 Brazil Brazil NNP cord-010092-uftc8inx 10206 27 with with IN cord-010092-uftc8inx 10206 28 a a DT cord-010092-uftc8inx 10206 29 history history NN cord-010092-uftc8inx 10206 30 of of IN cord-010092-uftc8inx 10206 31 4 4 CD cord-010092-uftc8inx 10206 32 pregnancies pregnancy NNS cord-010092-uftc8inx 10206 33 but but CC cord-010092-uftc8inx 10206 34 no no DT cord-010092-uftc8inx 10206 35 history history NN cord-010092-uftc8inx 10206 36 of of IN cord-010092-uftc8inx 10206 37 previous previous JJ cord-010092-uftc8inx 10206 38 transfusion transfusion NN cord-010092-uftc8inx 10206 39 . . . cord-010092-uftc8inx 10207 1 She -PRON- PRP cord-010092-uftc8inx 10207 2 required require VBD cord-010092-uftc8inx 10207 3 transfusion transfusion NN cord-010092-uftc8inx 10207 4 because because IN cord-010092-uftc8inx 10207 5 of of IN cord-010092-uftc8inx 10207 6 a a DT cord-010092-uftc8inx 10207 7 schedule schedule NN cord-010092-uftc8inx 10207 8 for for IN cord-010092-uftc8inx 10207 9 total total JJ cord-010092-uftc8inx 10207 10 thyroidectomy thyroidectomy NN cord-010092-uftc8inx 10207 11 surgery surgery NN cord-010092-uftc8inx 10207 12 due due IN cord-010092-uftc8inx 10207 13 to to IN cord-010092-uftc8inx 10207 14 a a DT cord-010092-uftc8inx 10207 15 large large JJ cord-010092-uftc8inx 10207 16 compressive compressive JJ cord-010092-uftc8inx 10207 17 nodular nodular JJ cord-010092-uftc8inx 10207 18 goiter goiter NN cord-010092-uftc8inx 10207 19 . . . cord-010092-uftc8inx 10208 1 The the DT cord-010092-uftc8inx 10208 2 antibody antibody NN cord-010092-uftc8inx 10208 3 did do VBD cord-010092-uftc8inx 10208 4 not not RB cord-010092-uftc8inx 10208 5 react react VB cord-010092-uftc8inx 10208 6 with with IN cord-010092-uftc8inx 10208 7 the the DT cord-010092-uftc8inx 10208 8 autologous autologous JJ cord-010092-uftc8inx 10208 9 RBCs rbc NNS cord-010092-uftc8inx 10208 10 but but CC cord-010092-uftc8inx 10208 11 reacted react VBD cord-010092-uftc8inx 10208 12 by by IN cord-010092-uftc8inx 10208 13 the the DT cord-010092-uftc8inx 10208 14 indirect indirect JJ cord-010092-uftc8inx 10208 15 antiglobulin antiglobulin NN cord-010092-uftc8inx 10208 16 test test NN cord-010092-uftc8inx 10208 17 in in IN cord-010092-uftc8inx 10208 18 LISS LISS NNP cord-010092-uftc8inx 10208 19 with with IN cord-010092-uftc8inx 10208 20 all all DT cord-010092-uftc8inx 10208 21 panel panel NN cord-010092-uftc8inx 10208 22 RBCs rbc NNS cord-010092-uftc8inx 10208 23 and and CC cord-010092-uftc8inx 10208 24 other other JJ cord-010092-uftc8inx 10208 25 RBC RBC NNP cord-010092-uftc8inx 10208 26 samples sample NNS cord-010092-uftc8inx 10208 27 tested test VBN cord-010092-uftc8inx 10208 28 except except IN cord-010092-uftc8inx 10208 29 with with IN cord-010092-uftc8inx 10208 30 the the DT cord-010092-uftc8inx 10208 31 Gy(a- gy(a- CD cord-010092-uftc8inx 10208 32 ) ) -RRB- cord-010092-uftc8inx 10208 33 phenotype phenotype NN cord-010092-uftc8inx 10208 34 . . . cord-010092-uftc8inx 10209 1 The the DT cord-010092-uftc8inx 10209 2 corresponding correspond VBG cord-010092-uftc8inx 10209 3 antigen antigen NN cord-010092-uftc8inx 10209 4 was be VBD cord-010092-uftc8inx 10209 5 resistant resistant JJ cord-010092-uftc8inx 10209 6 to to IN cord-010092-uftc8inx 10209 7 treatment treatment NN cord-010092-uftc8inx 10209 8 with with IN cord-010092-uftc8inx 10209 9 papain papain NN cord-010092-uftc8inx 10209 10 but but CC cord-010092-uftc8inx 10209 11 sensitive sensitive JJ cord-010092-uftc8inx 10209 12 to to IN cord-010092-uftc8inx 10209 13 DTT DTT NNP cord-010092-uftc8inx 10209 14 and and CC cord-010092-uftc8inx 10209 15 trypsin trypsin NN cord-010092-uftc8inx 10209 16 . . . cord-010092-uftc8inx 10210 1 These these DT cord-010092-uftc8inx 10210 2 results result NNS cord-010092-uftc8inx 10210 3 suggested suggest VBD cord-010092-uftc8inx 10210 4 that that IN cord-010092-uftc8inx 10210 5 the the DT cord-010092-uftc8inx 10210 6 antibody antibody NN cord-010092-uftc8inx 10210 7 recognized recognize VBD cord-010092-uftc8inx 10210 8 an an DT cord-010092-uftc8inx 10210 9 antigen antigen NN cord-010092-uftc8inx 10210 10 in in IN cord-010092-uftc8inx 10210 11 the the DT cord-010092-uftc8inx 10210 12 Dombrock Dombrock NNP cord-010092-uftc8inx 10210 13 blood blood NN cord-010092-uftc8inx 10210 14 group group NN cord-010092-uftc8inx 10210 15 system system NN cord-010092-uftc8inx 10210 16 . . . cord-010092-uftc8inx 10211 1 The the DT cord-010092-uftc8inx 10211 2 purpose purpose NN cord-010092-uftc8inx 10211 3 of of IN cord-010092-uftc8inx 10211 4 this this DT cord-010092-uftc8inx 10211 5 study study NN cord-010092-uftc8inx 10211 6 was be VBD cord-010092-uftc8inx 10211 7 to to TO cord-010092-uftc8inx 10211 8 identify identify VB cord-010092-uftc8inx 10211 9 the the DT cord-010092-uftc8inx 10211 10 antibody antibody NN cord-010092-uftc8inx 10211 11 specificity specificity NN cord-010092-uftc8inx 10211 12 and and CC cord-010092-uftc8inx 10211 13 to to TO cord-010092-uftc8inx 10211 14 determine determine VB cord-010092-uftc8inx 10211 15 the the DT cord-010092-uftc8inx 10211 16 molecular molecular JJ cord-010092-uftc8inx 10211 17 basis basis NN cord-010092-uftc8inx 10211 18 of of IN cord-010092-uftc8inx 10211 19 the the DT cord-010092-uftc8inx 10211 20 phenotype phenotype NN cord-010092-uftc8inx 10211 21 detected detect VBN cord-010092-uftc8inx 10211 22 . . . cord-010092-uftc8inx 10212 1 Methods method NNS cord-010092-uftc8inx 10212 2 : : : cord-010092-uftc8inx 10213 1 The the DT cord-010092-uftc8inx 10213 2 red red JJ cord-010092-uftc8inx 10213 3 cells cell NNS cord-010092-uftc8inx 10213 4 phenotype phenotype NN cord-010092-uftc8inx 10213 5 and and CC cord-010092-uftc8inx 10213 6 the the DT cord-010092-uftc8inx 10213 7 presence presence NN cord-010092-uftc8inx 10213 8 of of IN cord-010092-uftc8inx 10213 9 the the DT cord-010092-uftc8inx 10213 10 Dombrock Dombrock NNP cord-010092-uftc8inx 10213 11 related related JJ cord-010092-uftc8inx 10213 12 antibody antibody NN cord-010092-uftc8inx 10213 13 in in IN cord-010092-uftc8inx 10213 14 the the DT cord-010092-uftc8inx 10213 15 serum serum NN cord-010092-uftc8inx 10213 16 were be VBD cord-010092-uftc8inx 10213 17 detected detect VBN cord-010092-uftc8inx 10213 18 by by IN cord-010092-uftc8inx 10213 19 standard standard JJ cord-010092-uftc8inx 10213 20 hemagglutination hemagglutination NN cord-010092-uftc8inx 10213 21 techniques technique NNS cord-010092-uftc8inx 10213 22 . . . cord-010092-uftc8inx 10214 1 RBCs rbc NNS cord-010092-uftc8inx 10214 2 and and CC cord-010092-uftc8inx 10214 3 antibodies antibody NNS cord-010092-uftc8inx 10214 4 were be VBD cord-010092-uftc8inx 10214 5 from from IN cord-010092-uftc8inx 10214 6 our -PRON- PRP$ cord-010092-uftc8inx 10214 7 in in IN cord-010092-uftc8inx 10214 8 - - HYPH cord-010092-uftc8inx 10214 9 house house NN cord-010092-uftc8inx 10214 10 collection collection NN cord-010092-uftc8inx 10214 11 of of IN cord-010092-uftc8inx 10214 12 rare rare JJ cord-010092-uftc8inx 10214 13 samples sample NNS cord-010092-uftc8inx 10214 14 . . . cord-010092-uftc8inx 10215 1 Genomic genomic JJ cord-010092-uftc8inx 10215 2 DNA dna NN cord-010092-uftc8inx 10215 3 was be VBD cord-010092-uftc8inx 10215 4 prepared prepare VBN cord-010092-uftc8inx 10215 5 from from IN cord-010092-uftc8inx 10215 6 peripheral peripheral JJ cord-010092-uftc8inx 10215 7 blood blood NN cord-010092-uftc8inx 10215 8 of of IN cord-010092-uftc8inx 10215 9 the the DT cord-010092-uftc8inx 10215 10 patient patient NN cord-010092-uftc8inx 10215 11 . . . cord-010092-uftc8inx 10216 1 Dombrock Dombrock NNP cord-010092-uftc8inx 10216 2 genotyping genotyping NN cord-010092-uftc8inx 10216 3 was be VBD cord-010092-uftc8inx 10216 4 performed perform VBN cord-010092-uftc8inx 10216 5 by by IN cord-010092-uftc8inx 10216 6 ID ID NNP cord-010092-uftc8inx 10216 7 - - HYPH cord-010092-uftc8inx 10216 8 Core Core NNP cord-010092-uftc8inx 10216 9 XT XT NNP cord-010092-uftc8inx 10216 10 platform platform NN cord-010092-uftc8inx 10216 11 ( ( -LRB- cord-010092-uftc8inx 10216 12 Grifols Grifols NNP cord-010092-uftc8inx 10216 13 , , , cord-010092-uftc8inx 10216 14 Spain Spain NNP cord-010092-uftc8inx 10216 15 ) ) -RRB- cord-010092-uftc8inx 10216 16 . . . cord-010092-uftc8inx 10217 1 The the DT cord-010092-uftc8inx 10217 2 3 3 CD cord-010092-uftc8inx 10217 3 exons exon NNS cord-010092-uftc8inx 10217 4 of of IN cord-010092-uftc8inx 10217 5 the the DT cord-010092-uftc8inx 10217 6 DO DO NNP cord-010092-uftc8inx 10217 7 gene gene NN cord-010092-uftc8inx 10217 8 were be VBD cord-010092-uftc8inx 10217 9 amplified amplify VBN cord-010092-uftc8inx 10217 10 by by IN cord-010092-uftc8inx 10217 11 PCR PCR NNP cord-010092-uftc8inx 10217 12 and and CC cord-010092-uftc8inx 10217 13 directly directly RB cord-010092-uftc8inx 10217 14 sequenced sequence VBN cord-010092-uftc8inx 10217 15 . . . cord-010092-uftc8inx 10218 1 Experimental Experimental NNP cord-010092-uftc8inx 10218 2 Immunohematology Immunohematology NNP cord-010092-uftc8inx 10218 3 and and CC cord-010092-uftc8inx 10218 4 Diagnostic Diagnostic NNP cord-010092-uftc8inx 10218 5 Immunohematology Immunohematology NNP cord-010092-uftc8inx 10218 6 2 2 CD cord-010092-uftc8inx 10218 7 Diagnostic Diagnostic NNP cord-010092-uftc8inx 10218 8 Immunohematology Immunohematology NNP cord-010092-uftc8inx 10218 9 3 3 CD cord-010092-uftc8inx 10218 10 Experimental Experimental NNP cord-010092-uftc8inx 10218 11 Immunohematology Immunohematology NNP cord-010092-uftc8inx 10218 12 , , , cord-010092-uftc8inx 10218 13 Sanquin Sanquin NNP cord-010092-uftc8inx 10218 14 , , , cord-010092-uftc8inx 10218 15 Amsterdam Amsterdam NNP cord-010092-uftc8inx 10218 16 , , , cord-010092-uftc8inx 10219 1 Netherlands Netherlands NNP cord-010092-uftc8inx 10219 2 Background Background NNP cord-010092-uftc8inx 10219 3 : : : cord-010092-uftc8inx 10219 4 Typing typing NN cord-010092-uftc8inx 10219 5 of of IN cord-010092-uftc8inx 10219 6 blood blood NN cord-010092-uftc8inx 10219 7 group group NN cord-010092-uftc8inx 10219 8 antigens antigen NNS cord-010092-uftc8inx 10219 9 is be VBZ cord-010092-uftc8inx 10219 10 essential essential JJ cord-010092-uftc8inx 10219 11 to to TO cord-010092-uftc8inx 10219 12 prevent prevent VB cord-010092-uftc8inx 10219 13 transfusion transfusion NN cord-010092-uftc8inx 10219 14 reactions reaction NNS cord-010092-uftc8inx 10219 15 or or CC cord-010092-uftc8inx 10219 16 haemolytic haemolytic JJ cord-010092-uftc8inx 10219 17 disease disease NN cord-010092-uftc8inx 10219 18 of of IN cord-010092-uftc8inx 10219 19 the the DT cord-010092-uftc8inx 10219 20 foetus foetus NN cord-010092-uftc8inx 10219 21 and and CC cord-010092-uftc8inx 10219 22 newborn newborn JJ cord-010092-uftc8inx 10219 23 . . . cord-010092-uftc8inx 10220 1 To to IN cord-010092-uftc8inx 10220 2 date date NN cord-010092-uftc8inx 10220 3 , , , cord-010092-uftc8inx 10220 4 the the DT cord-010092-uftc8inx 10220 5 ISBT ISBT NNP cord-010092-uftc8inx 10220 6 recognises recognise VBZ cord-010092-uftc8inx 10220 7 360 360 CD cord-010092-uftc8inx 10220 8 blood blood NN cord-010092-uftc8inx 10220 9 group group NN cord-010092-uftc8inx 10220 10 antigens antigen NNS cord-010092-uftc8inx 10220 11 . . . cord-010092-uftc8inx 10221 1 Most Most JJS cord-010092-uftc8inx 10221 2 antigens antigen NNS cord-010092-uftc8inx 10221 3 ( ( -LRB- cord-010092-uftc8inx 10221 4 322 322 CD cord-010092-uftc8inx 10221 5 ) ) -RRB- cord-010092-uftc8inx 10221 6 belong belong VB cord-010092-uftc8inx 10221 7 to to IN cord-010092-uftc8inx 10221 8 one one CD cord-010092-uftc8inx 10221 9 of of IN cord-010092-uftc8inx 10221 10 the the DT cord-010092-uftc8inx 10221 11 36 36 CD cord-010092-uftc8inx 10221 12 blood blood NN cord-010092-uftc8inx 10221 13 group group NN cord-010092-uftc8inx 10221 14 systems system NNS cord-010092-uftc8inx 10221 15 . . . cord-010092-uftc8inx 10222 1 Since since IN cord-010092-uftc8inx 10222 2 the the DT cord-010092-uftc8inx 10222 3 genetic genetic JJ cord-010092-uftc8inx 10222 4 basis basis NN cord-010092-uftc8inx 10222 5 of of IN cord-010092-uftc8inx 10222 6 these these DT cord-010092-uftc8inx 10222 7 systems system NNS cord-010092-uftc8inx 10222 8 is be VBZ cord-010092-uftc8inx 10222 9 known know VBN cord-010092-uftc8inx 10222 10 , , , cord-010092-uftc8inx 10222 11 genotyping genotype VBG cord-010092-uftc8inx 10222 12 of of IN cord-010092-uftc8inx 10222 13 these these DT cord-010092-uftc8inx 10222 14 antigens antigen NNS cord-010092-uftc8inx 10222 15 is be VBZ cord-010092-uftc8inx 10222 16 possible possible JJ cord-010092-uftc8inx 10222 17 . . . cord-010092-uftc8inx 10223 1 The the DT cord-010092-uftc8inx 10223 2 molecular molecular JJ cord-010092-uftc8inx 10223 3 background background NN cord-010092-uftc8inx 10223 4 of of IN cord-010092-uftc8inx 10223 5 38 38 CD cord-010092-uftc8inx 10223 6 antigens antigen NNS cord-010092-uftc8inx 10223 7 is be VBZ cord-010092-uftc8inx 10223 8 unknown unknown JJ cord-010092-uftc8inx 10223 9 and and CC cord-010092-uftc8inx 10223 10 can can MD cord-010092-uftc8inx 10223 11 only only RB cord-010092-uftc8inx 10223 12 be be VB cord-010092-uftc8inx 10223 13 determined determine VBN cord-010092-uftc8inx 10223 14 serologically serologically RB cord-010092-uftc8inx 10223 15 . . . cord-010092-uftc8inx 10224 1 One one CD cord-010092-uftc8inx 10224 2 of of IN cord-010092-uftc8inx 10224 3 these these DT cord-010092-uftc8inx 10224 4 antigens antigen NNS cord-010092-uftc8inx 10224 5 is be VBZ cord-010092-uftc8inx 10224 6 Sd Sd NNP cord-010092-uftc8inx 10224 7 a a DT cord-010092-uftc8inx 10224 8 ( ( -LRB- cord-010092-uftc8inx 10224 9 Sid Sid NNP cord-010092-uftc8inx 10224 10 ) ) -RRB- cord-010092-uftc8inx 10224 11 , , , cord-010092-uftc8inx 10224 12 first first RB cord-010092-uftc8inx 10224 13 reported report VBD cord-010092-uftc8inx 10224 14 in in IN cord-010092-uftc8inx 10224 15 1967.~91 1967.~91 CD cord-010092-uftc8inx 10224 16 % % NN cord-010092-uftc8inx 10224 17 of of IN cord-010092-uftc8inx 10224 18 the the DT cord-010092-uftc8inx 10224 19 population population NN cord-010092-uftc8inx 10224 20 carry carry VBP cord-010092-uftc8inx 10224 21 Sd Sd NNP cord-010092-uftc8inx 10224 22 a a DT cord-010092-uftc8inx 10224 23 on on IN cord-010092-uftc8inx 10224 24 erythrocytes erythrocyte NNS cord-010092-uftc8inx 10224 25 , , , cord-010092-uftc8inx 10224 26 but but CC cord-010092-uftc8inx 10224 27 this this DT cord-010092-uftc8inx 10224 28 frequency frequency NN cord-010092-uftc8inx 10224 29 might may MD cord-010092-uftc8inx 10224 30 be be VB cord-010092-uftc8inx 10224 31 higher high JJR cord-010092-uftc8inx 10224 32 since since IN cord-010092-uftc8inx 10224 33 identification identification NN cord-010092-uftc8inx 10224 34 is be VBZ cord-010092-uftc8inx 10224 35 difficult difficult JJ cord-010092-uftc8inx 10224 36 due due IN cord-010092-uftc8inx 10224 37 to to IN cord-010092-uftc8inx 10224 38 variability variability NN cord-010092-uftc8inx 10224 39 in in IN cord-010092-uftc8inx 10224 40 expression expression NN cord-010092-uftc8inx 10224 41 . . . cord-010092-uftc8inx 10225 1 In in IN cord-010092-uftc8inx 10225 2 96 96 CD cord-010092-uftc8inx 10225 3 % % NN cord-010092-uftc8inx 10225 4 of of IN cord-010092-uftc8inx 10225 5 individuals individual NNS cord-010092-uftc8inx 10225 6 Sd Sd NNP cord-010092-uftc8inx 10225 7 a a NNP cord-010092-uftc8inx 10225 8 is be VBZ cord-010092-uftc8inx 10225 9 present present JJ cord-010092-uftc8inx 10225 10 in in IN cord-010092-uftc8inx 10225 11 urine urine NN cord-010092-uftc8inx 10225 12 . . . cord-010092-uftc8inx 10226 1 Cells cell NNS cord-010092-uftc8inx 10226 2 with with IN cord-010092-uftc8inx 10226 3 a a DT cord-010092-uftc8inx 10226 4 high high JJ cord-010092-uftc8inx 10226 5 expression expression NN cord-010092-uftc8inx 10226 6 of of IN cord-010092-uftc8inx 10226 7 Sd Sd NNP cord-010092-uftc8inx 10226 8 a a DT cord-010092-uftc8inx 10226 9 ( ( -LRB- cord-010092-uftc8inx 10226 10 Cad Cad NNP cord-010092-uftc8inx 10226 11 / / SYM cord-010092-uftc8inx 10226 12 Sda++ Sda++ NNP cord-010092-uftc8inx 10226 13 ) ) -RRB- cord-010092-uftc8inx 10226 14 are be VBP cord-010092-uftc8inx 10226 15 used use VBN cord-010092-uftc8inx 10226 16 for for IN cord-010092-uftc8inx 10226 17 detection detection NN cord-010092-uftc8inx 10226 18 of of IN cord-010092-uftc8inx 10226 19 antibodies antibody NNS cord-010092-uftc8inx 10226 20 . . . cord-010092-uftc8inx 10227 1 Recently recently RB cord-010092-uftc8inx 10227 2 , , , cord-010092-uftc8inx 10227 3 a a DT cord-010092-uftc8inx 10227 4 3-cells 3-cells CD cord-010092-uftc8inx 10227 5 antibody antibody NN cord-010092-uftc8inx 10227 6 detection detection NN cord-010092-uftc8inx 10227 7 panel panel NN cord-010092-uftc8inx 10227 8 of of IN cord-010092-uftc8inx 10227 9 Bio Bio NNP cord-010092-uftc8inx 10227 10 - - HYPH cord-010092-uftc8inx 10227 11 Rad Rad NNP cord-010092-uftc8inx 10227 12 contained contain VBD cord-010092-uftc8inx 10227 13 a a DT cord-010092-uftc8inx 10227 14 Sda++ Sda++ NNP cord-010092-uftc8inx 10227 15 cell cell NN cord-010092-uftc8inx 10227 16 and and CC cord-010092-uftc8inx 10227 17 many many JJ cord-010092-uftc8inx 10227 18 individuals individual NNS cord-010092-uftc8inx 10227 19 with with IN cord-010092-uftc8inx 10227 20 anti anti JJ cord-010092-uftc8inx 10227 21 - - JJ cord-010092-uftc8inx 10227 22 Sd Sd NNP cord-010092-uftc8inx 10227 23 a a DT cord-010092-uftc8inx 10227 24 were be VBD cord-010092-uftc8inx 10227 25 detected detect VBN cord-010092-uftc8inx 10227 26 . . . cord-010092-uftc8inx 10228 1 The the DT cord-010092-uftc8inx 10228 2 B4GALNT2 b4galnt2 NN cord-010092-uftc8inx 10228 3 gene gene NN cord-010092-uftc8inx 10228 4 has have VBZ cord-010092-uftc8inx 10228 5 been be VBN cord-010092-uftc8inx 10228 6 implicated implicate VBN cord-010092-uftc8inx 10228 7 in in IN cord-010092-uftc8inx 10228 8 the the DT cord-010092-uftc8inx 10228 9 synthesis synthesis NN cord-010092-uftc8inx 10228 10 of of IN cord-010092-uftc8inx 10228 11 Sd Sd NNP cord-010092-uftc8inx 10228 12 a a NNP cord-010092-uftc8inx 10228 13 . . . cord-010092-uftc8inx 10229 1 We -PRON- PRP cord-010092-uftc8inx 10229 2 collected collect VBD cord-010092-uftc8inx 10229 3 individuals individual NNS cord-010092-uftc8inx 10229 4 with with IN cord-010092-uftc8inx 10229 5 and and CC cord-010092-uftc8inx 10229 6 without without IN cord-010092-uftc8inx 10229 7 anti anti JJ cord-010092-uftc8inx 10229 8 - - JJ cord-010092-uftc8inx 10229 9 Sd Sd NNP cord-010092-uftc8inx 10229 10 a a DT cord-010092-uftc8inx 10229 11 to to TO cord-010092-uftc8inx 10229 12 elucidate elucidate VB cord-010092-uftc8inx 10229 13 the the DT cord-010092-uftc8inx 10229 14 genetic genetic JJ cord-010092-uftc8inx 10229 15 background background NN cord-010092-uftc8inx 10229 16 of of IN cord-010092-uftc8inx 10229 17 the the DT cord-010092-uftc8inx 10229 18 antigen antigen NN cord-010092-uftc8inx 10229 19 . . . cord-010092-uftc8inx 10230 1 Aims aim VBZ cord-010092-uftc8inx 10230 2 : : : cord-010092-uftc8inx 10231 1 Elucidation elucidation NN cord-010092-uftc8inx 10231 2 of of IN cord-010092-uftc8inx 10231 3 the the DT cord-010092-uftc8inx 10231 4 genetic genetic JJ cord-010092-uftc8inx 10231 5 basis basis NN cord-010092-uftc8inx 10231 6 responsible responsible JJ cord-010092-uftc8inx 10231 7 for for IN cord-010092-uftc8inx 10231 8 loss loss NN cord-010092-uftc8inx 10231 9 of of IN cord-010092-uftc8inx 10231 10 the the DT cord-010092-uftc8inx 10231 11 Sd Sd NNP cord-010092-uftc8inx 10231 12 a a DT cord-010092-uftc8inx 10231 13 antigen antigen NN cord-010092-uftc8inx 10231 14 on on IN cord-010092-uftc8inx 10231 15 red red JJ cord-010092-uftc8inx 10231 16 blood blood NN cord-010092-uftc8inx 10231 17 cells cell NNS cord-010092-uftc8inx 10231 18 . . . cord-010092-uftc8inx 10232 1 Methods method NNS cord-010092-uftc8inx 10232 2 : : : cord-010092-uftc8inx 10232 3 Routine routine JJ cord-010092-uftc8inx 10232 4 diagnostics diagnostic NNS cord-010092-uftc8inx 10232 5 to to TO cord-010092-uftc8inx 10232 6 identify identify VB cord-010092-uftc8inx 10232 7 antibodies antibody NNS cord-010092-uftc8inx 10232 8 in in IN cord-010092-uftc8inx 10232 9 patients patient NNS cord-010092-uftc8inx 10232 10 was be VBD cord-010092-uftc8inx 10232 11 performed perform VBN cord-010092-uftc8inx 10232 12 using use VBG cord-010092-uftc8inx 10232 13 a a DT cord-010092-uftc8inx 10232 14 Bio Bio NNP cord-010092-uftc8inx 10232 15 - - HYPH cord-010092-uftc8inx 10232 16 Rad Rad NNP cord-010092-uftc8inx 10232 17 3-cells 3-cells CD cord-010092-uftc8inx 10232 18 panel panel NN cord-010092-uftc8inx 10232 19 , , , cord-010092-uftc8inx 10232 20 containing contain VBG cord-010092-uftc8inx 10232 21 donor donor NN cord-010092-uftc8inx 10232 22 626521 626521 CD cord-010092-uftc8inx 10232 23 with with IN cord-010092-uftc8inx 10232 24 high high JJ cord-010092-uftc8inx 10232 25 expression expression NN cord-010092-uftc8inx 10232 26 of of IN cord-010092-uftc8inx 10232 27 Sd Sd NNP cord-010092-uftc8inx 10232 28 a a NN cord-010092-uftc8inx 10232 29 . . . cord-010092-uftc8inx 10233 1 Additionally additionally RB cord-010092-uftc8inx 10233 2 , , , cord-010092-uftc8inx 10233 3 200 200 CD cord-010092-uftc8inx 10233 4 pregnant pregnant JJ cord-010092-uftc8inx 10233 5 women woman NNS cord-010092-uftc8inx 10233 6 were be VBD cord-010092-uftc8inx 10233 7 screened screen VBN cord-010092-uftc8inx 10233 8 for for IN cord-010092-uftc8inx 10233 9 anti anti JJ cord-010092-uftc8inx 10233 10 - - JJ cord-010092-uftc8inx 10233 11 Sd Sd NNP cord-010092-uftc8inx 10233 12 a a NN cord-010092-uftc8inx 10233 13 . . . cord-010092-uftc8inx 10234 1 DNA DNA NNP cord-010092-uftc8inx 10234 2 of of IN cord-010092-uftc8inx 10234 3 eight eight CD cord-010092-uftc8inx 10234 4 samples sample NNS cord-010092-uftc8inx 10234 5 with with IN cord-010092-uftc8inx 10234 6 anti anti JJ cord-010092-uftc8inx 10234 7 - - JJ cord-010092-uftc8inx 10234 8 Sd Sd NNP cord-010092-uftc8inx 10234 9 a a NN cord-010092-uftc8inx 10234 10 and and CC cord-010092-uftc8inx 10234 11 eight eight CD cord-010092-uftc8inx 10234 12 samples sample NNS cord-010092-uftc8inx 10234 13 without without IN cord-010092-uftc8inx 10234 14 anti anti JJ cord-010092-uftc8inx 10234 15 - - JJ cord-010092-uftc8inx 10234 16 Sd Sd NNP cord-010092-uftc8inx 10234 17 a a NN cord-010092-uftc8inx 10234 18 was be VBD cord-010092-uftc8inx 10234 19 isolated isolate VBN cord-010092-uftc8inx 10234 20 for for IN cord-010092-uftc8inx 10234 21 further further JJ cord-010092-uftc8inx 10234 22 analysis analysis NN cord-010092-uftc8inx 10234 23 . . . cord-010092-uftc8inx 10235 1 Sanger Sanger NNP cord-010092-uftc8inx 10235 2 sequencing sequencing NN cord-010092-uftc8inx 10235 3 was be VBD cord-010092-uftc8inx 10235 4 performed perform VBN cord-010092-uftc8inx 10235 5 on on IN cord-010092-uftc8inx 10235 6 B4GALTNT2 B4GALTNT2 NNP cord-010092-uftc8inx 10235 7 exon exon NN cord-010092-uftc8inx 10235 8 1 1 CD cord-010092-uftc8inx 10235 9 - - SYM cord-010092-uftc8inx 10235 10 11 11 CD cord-010092-uftc8inx 10235 11 . . . cord-010092-uftc8inx 10236 1 Results result NNS cord-010092-uftc8inx 10236 2 : : : cord-010092-uftc8inx 10237 1 Sequencing sequencing NN cord-010092-uftc8inx 10237 2 of of IN cord-010092-uftc8inx 10237 3 B4GALTNT2 B4GALTNT2 NNP cord-010092-uftc8inx 10237 4 revealed reveal VBD cord-010092-uftc8inx 10237 5 two two CD cord-010092-uftc8inx 10237 6 homozygous homozygous JJ cord-010092-uftc8inx 10237 7 mutations mutation NNS cord-010092-uftc8inx 10237 8 which which WDT cord-010092-uftc8inx 10237 9 are be VBP cord-010092-uftc8inx 10237 10 present present JJ cord-010092-uftc8inx 10237 11 in in IN cord-010092-uftc8inx 10237 12 all all DT cord-010092-uftc8inx 10237 13 eight eight CD cord-010092-uftc8inx 10237 14 individuals individual NNS cord-010092-uftc8inx 10237 15 with with IN cord-010092-uftc8inx 10237 16 anti anti JJ cord-010092-uftc8inx 10237 17 - - JJ cord-010092-uftc8inx 10237 18 Sd Sd NNP cord-010092-uftc8inx 10237 19 a a NN cord-010092-uftc8inx 10237 20 , , , cord-010092-uftc8inx 10237 21 but but CC cord-010092-uftc8inx 10237 22 not not RB cord-010092-uftc8inx 10237 23 present present JJ cord-010092-uftc8inx 10237 24 in in IN cord-010092-uftc8inx 10237 25 6 6 CD cord-010092-uftc8inx 10237 26 controls control NNS cord-010092-uftc8inx 10237 27 . . . cord-010092-uftc8inx 10238 1 The the DT cord-010092-uftc8inx 10238 2 remaining remain VBG cord-010092-uftc8inx 10238 3 two two CD cord-010092-uftc8inx 10238 4 controls control NNS cord-010092-uftc8inx 10238 5 are be VBP cord-010092-uftc8inx 10238 6 heterozygous heterozygous JJ cord-010092-uftc8inx 10238 7 for for IN cord-010092-uftc8inx 10238 8 these these DT cord-010092-uftc8inx 10238 9 mutations mutation NNS cord-010092-uftc8inx 10238 10 . . . cord-010092-uftc8inx 10239 1 The the DT cord-010092-uftc8inx 10239 2 first first JJ cord-010092-uftc8inx 10239 3 mutation mutation NN cord-010092-uftc8inx 10239 4 within within IN cord-010092-uftc8inx 10239 5 exon exon NN cord-010092-uftc8inx 10239 6 10 10 CD cord-010092-uftc8inx 10239 7 , , , cord-010092-uftc8inx 10240 1 c.1396T c.1396T NNP cord-010092-uftc8inx 10240 2 > > XX cord-010092-uftc8inx 10240 3 C c NN cord-010092-uftc8inx 10240 4 ( ( -LRB- cord-010092-uftc8inx 10240 5 ENST00000300404.2 ENST00000300404.2 NNP cord-010092-uftc8inx 10240 6 , , , cord-010092-uftc8inx 10240 7 rs7224888 rs7224888 NNP cord-010092-uftc8inx 10240 8 ) ) -RRB- cord-010092-uftc8inx 10240 9 changes change VBZ cord-010092-uftc8inx 10240 10 a a DT cord-010092-uftc8inx 10240 11 cysteine cysteine NN cord-010092-uftc8inx 10240 12 to to IN cord-010092-uftc8inx 10240 13 arginine arginine NN cord-010092-uftc8inx 10240 14 at at IN cord-010092-uftc8inx 10240 15 position position NN cord-010092-uftc8inx 10240 16 466 466 CD cord-010092-uftc8inx 10240 17 of of IN cord-010092-uftc8inx 10240 18 the the DT cord-010092-uftc8inx 10240 19 protein protein NN cord-010092-uftc8inx 10240 20 . . . cord-010092-uftc8inx 10241 1 The the DT cord-010092-uftc8inx 10241 2 second second JJ cord-010092-uftc8inx 10241 3 mutation mutation NN cord-010092-uftc8inx 10241 4 in in IN cord-010092-uftc8inx 10241 5 exon exon NN cord-010092-uftc8inx 10241 6 11 11 CD cord-010092-uftc8inx 10242 1 c.1590A c.1590A NNP cord-010092-uftc8inx 10242 2 > > XX cord-010092-uftc8inx 10242 3 G g NN cord-010092-uftc8inx 10242 4 ( ( -LRB- cord-010092-uftc8inx 10242 5 rs16946912 rs16946912 NN cord-010092-uftc8inx 10242 6 ) ) -RRB- cord-010092-uftc8inx 10242 7 does do VBZ cord-010092-uftc8inx 10242 8 not not RB cord-010092-uftc8inx 10242 9 change change VB cord-010092-uftc8inx 10242 10 an an DT cord-010092-uftc8inx 10242 11 amino amino NN cord-010092-uftc8inx 10242 12 acid acid NN cord-010092-uftc8inx 10242 13 . . . cord-010092-uftc8inx 10243 1 Both both DT cord-010092-uftc8inx 10243 2 SNPs snp NNS cord-010092-uftc8inx 10243 3 have have VBP cord-010092-uftc8inx 10243 4 a a DT cord-010092-uftc8inx 10243 5 MAF maf NN cord-010092-uftc8inx 10243 6 of of IN cord-010092-uftc8inx 10243 7 0.11 0.11 CD cord-010092-uftc8inx 10243 8 and and CC cord-010092-uftc8inx 10243 9 therefore therefore RB cord-010092-uftc8inx 10243 10 we -PRON- PRP cord-010092-uftc8inx 10243 11 expect expect VBP cord-010092-uftc8inx 10243 12 that that IN cord-010092-uftc8inx 10243 13 2.1 2.1 CD cord-010092-uftc8inx 10243 14 % % NN cord-010092-uftc8inx 10243 15 of of IN cord-010092-uftc8inx 10243 16 the the DT cord-010092-uftc8inx 10243 17 population population NN cord-010092-uftc8inx 10243 18 is be VBZ cord-010092-uftc8inx 10243 19 homozygous homozygous JJ cord-010092-uftc8inx 10243 20 for for IN cord-010092-uftc8inx 10243 21 the the DT cord-010092-uftc8inx 10243 22 minor minor JJ cord-010092-uftc8inx 10243 23 allele allele NN cord-010092-uftc8inx 10243 24 . . . cord-010092-uftc8inx 10244 1 Genotyping genotype VBG cord-010092-uftc8inx 10244 2 of of IN cord-010092-uftc8inx 10244 3 a a DT cord-010092-uftc8inx 10244 4 large large JJ cord-010092-uftc8inx 10244 5 population population NN cord-010092-uftc8inx 10244 6 of of IN cord-010092-uftc8inx 10244 7 pregnant pregnant JJ cord-010092-uftc8inx 10244 8 women woman NNS cord-010092-uftc8inx 10244 9 and and CC cord-010092-uftc8inx 10244 10 the the DT cord-010092-uftc8inx 10244 11 serological serological JJ cord-010092-uftc8inx 10244 12 detection detection NN cord-010092-uftc8inx 10244 13 of of IN cord-010092-uftc8inx 10244 14 anti anti JJ cord-010092-uftc8inx 10244 15 - - JJ cord-010092-uftc8inx 10244 16 Sd Sd NNP cord-010092-uftc8inx 10244 17 a a DT cord-010092-uftc8inx 10244 18 in in IN cord-010092-uftc8inx 10244 19 women woman NNS cord-010092-uftc8inx 10244 20 with with IN cord-010092-uftc8inx 10244 21 a a DT cord-010092-uftc8inx 10244 22 homozygous homozygous JJ cord-010092-uftc8inx 10244 23 mutation mutation NN cord-010092-uftc8inx 10244 24 is be VBZ cord-010092-uftc8inx 10244 25 in in IN cord-010092-uftc8inx 10244 26 progress progress NN cord-010092-uftc8inx 10244 27 . . . cord-010092-uftc8inx 10245 1 Summary Summary NNP cord-010092-uftc8inx 10245 2 / / SYM cord-010092-uftc8inx 10245 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 10245 4 : : : cord-010092-uftc8inx 10246 1 The the DT cord-010092-uftc8inx 10246 2 high high JJ cord-010092-uftc8inx 10246 3 frequency frequency NN cord-010092-uftc8inx 10246 4 antigen antigen NN cord-010092-uftc8inx 10246 5 Sd Sd NNP cord-010092-uftc8inx 10246 6 a a NN cord-010092-uftc8inx 10246 7 has have VBZ cord-010092-uftc8inx 10246 8 not not RB cord-010092-uftc8inx 10246 9 been be VBN cord-010092-uftc8inx 10246 10 linked link VBN cord-010092-uftc8inx 10246 11 to to IN cord-010092-uftc8inx 10246 12 a a DT cord-010092-uftc8inx 10246 13 blood blood NN cord-010092-uftc8inx 10246 14 group group NN cord-010092-uftc8inx 10246 15 system system NN cord-010092-uftc8inx 10246 16 because because IN cord-010092-uftc8inx 10246 17 the the DT cord-010092-uftc8inx 10246 18 molecular molecular JJ cord-010092-uftc8inx 10246 19 basis basis NN cord-010092-uftc8inx 10246 20 for for IN cord-010092-uftc8inx 10246 21 loss loss NN cord-010092-uftc8inx 10246 22 of of IN cord-010092-uftc8inx 10246 23 the the DT cord-010092-uftc8inx 10246 24 antigen antigen NN cord-010092-uftc8inx 10246 25 has have VBZ cord-010092-uftc8inx 10246 26 not not RB cord-010092-uftc8inx 10246 27 been be VBN cord-010092-uftc8inx 10246 28 elucidated elucidate VBN cord-010092-uftc8inx 10246 29 . . . cord-010092-uftc8inx 10247 1 The the DT cord-010092-uftc8inx 10247 2 B4GALTNT2 B4GALTNT2 NNP cord-010092-uftc8inx 10247 3 gene gene NN cord-010092-uftc8inx 10247 4 has have VBZ cord-010092-uftc8inx 10247 5 been be VBN cord-010092-uftc8inx 10247 6 associated associate VBN cord-010092-uftc8inx 10247 7 with with IN cord-010092-uftc8inx 10247 8 Sd Sd NNP cord-010092-uftc8inx 10247 9 a a DT cord-010092-uftc8inx 10247 10 synthesis synthesis NN cord-010092-uftc8inx 10247 11 and and CC cord-010092-uftc8inx 10247 12 therefore therefore RB cord-010092-uftc8inx 10247 13 we -PRON- PRP cord-010092-uftc8inx 10247 14 analysed analyse VBD cord-010092-uftc8inx 10247 15 this this DT cord-010092-uftc8inx 10247 16 gene gene NN cord-010092-uftc8inx 10247 17 for for IN cord-010092-uftc8inx 10247 18 mutations mutation NNS cord-010092-uftc8inx 10247 19 in in IN cord-010092-uftc8inx 10247 20 individuals individual NNS cord-010092-uftc8inx 10247 21 with with IN cord-010092-uftc8inx 10247 22 antibodies antibody NNS cord-010092-uftc8inx 10247 23 against against IN cord-010092-uftc8inx 10247 24 Sd Sd NNP cord-010092-uftc8inx 10247 25 a a NNP cord-010092-uftc8inx 10247 26 . . . cord-010092-uftc8inx 10248 1 A a DT cord-010092-uftc8inx 10248 2 single single JJ cord-010092-uftc8inx 10248 3 homozygous homozygous JJ cord-010092-uftc8inx 10248 4 mutation mutation NN cord-010092-uftc8inx 10248 5 within within IN cord-010092-uftc8inx 10248 6 exon exon NN cord-010092-uftc8inx 10248 7 10 10 CD cord-010092-uftc8inx 10248 8 causing cause VBG cord-010092-uftc8inx 10248 9 an an DT cord-010092-uftc8inx 10248 10 amino amino NN cord-010092-uftc8inx 10248 11 acid acid NN cord-010092-uftc8inx 10248 12 change change NN cord-010092-uftc8inx 10248 13 was be VBD cord-010092-uftc8inx 10248 14 found find VBN cord-010092-uftc8inx 10248 15 in in IN cord-010092-uftc8inx 10248 16 all all DT cord-010092-uftc8inx 10248 17 individuals individual NNS cord-010092-uftc8inx 10248 18 with with IN cord-010092-uftc8inx 10248 19 anti anti JJ cord-010092-uftc8inx 10248 20 - - JJ cord-010092-uftc8inx 10248 21 Sd Sd NNP cord-010092-uftc8inx 10248 22 a a NN cord-010092-uftc8inx 10248 23 , , , cord-010092-uftc8inx 10248 24 and and CC cord-010092-uftc8inx 10248 25 no no DT cord-010092-uftc8inx 10248 26 individuals individual NNS cord-010092-uftc8inx 10248 27 without without IN cord-010092-uftc8inx 10248 28 antibodies antibody NNS cord-010092-uftc8inx 10248 29 were be VBD cord-010092-uftc8inx 10248 30 homozygous homozygous JJ cord-010092-uftc8inx 10248 31 for for IN cord-010092-uftc8inx 10248 32 this this DT cord-010092-uftc8inx 10248 33 SNP SNP NNP cord-010092-uftc8inx 10248 34 . . . cord-010092-uftc8inx 10249 1 From from IN cord-010092-uftc8inx 10249 2 population population NN cord-010092-uftc8inx 10249 3 studies study NNS cord-010092-uftc8inx 10249 4 we -PRON- PRP cord-010092-uftc8inx 10249 5 expected~4 expected~4 VBP cord-010092-uftc8inx 10249 6 % % NN cord-010092-uftc8inx 10250 1 Sd Sd NNP cord-010092-uftc8inx 10250 2 a a DT cord-010092-uftc8inx 10250 3 -negatives -negative NNS cord-010092-uftc8inx 10251 1 , , , cord-010092-uftc8inx 10251 2 but but CC cord-010092-uftc8inx 10251 3 either either CC cord-010092-uftc8inx 10251 4 this this DT cord-010092-uftc8inx 10251 5 frequency frequency NN cord-010092-uftc8inx 10251 6 is be VBZ cord-010092-uftc8inx 10251 7 an an DT cord-010092-uftc8inx 10251 8 overestimation overestimation NN cord-010092-uftc8inx 10251 9 because because IN cord-010092-uftc8inx 10251 10 of of IN cord-010092-uftc8inx 10251 11 difficulties difficulty NNS cord-010092-uftc8inx 10251 12 to to TO cord-010092-uftc8inx 10251 13 detect detect VB cord-010092-uftc8inx 10251 14 low low JJ cord-010092-uftc8inx 10251 15 expressed express VBN cord-010092-uftc8inx 10251 16 antigens antigen NNS cord-010092-uftc8inx 10251 17 or or CC cord-010092-uftc8inx 10251 18 mutations mutation NNS cord-010092-uftc8inx 10251 19 in in IN cord-010092-uftc8inx 10251 20 other other JJ cord-010092-uftc8inx 10251 21 genes gene NNS cord-010092-uftc8inx 10251 22 are be VBP cord-010092-uftc8inx 10251 23 interfering interfere VBG cord-010092-uftc8inx 10251 24 with with IN cord-010092-uftc8inx 10251 25 Sd Sd NNP cord-010092-uftc8inx 10251 26 a a DT cord-010092-uftc8inx 10251 27 synthesis synthesis NN cord-010092-uftc8inx 10251 28 . . . cord-010092-uftc8inx 10252 1 A a DT cord-010092-uftc8inx 10252 2 larger large JJR cord-010092-uftc8inx 10252 3 study study NN cord-010092-uftc8inx 10252 4 of of IN cord-010092-uftc8inx 10252 5 individuals individual NNS cord-010092-uftc8inx 10252 6 with with IN cord-010092-uftc8inx 10252 7 homozygous homozygous JJ cord-010092-uftc8inx 10252 8 mutations mutation NNS cord-010092-uftc8inx 10252 9 in in IN cord-010092-uftc8inx 10252 10 B4GALNT2 b4galnt2 NN cord-010092-uftc8inx 10252 11 and and CC cord-010092-uftc8inx 10252 12 linkage linkage NN cord-010092-uftc8inx 10252 13 to to IN cord-010092-uftc8inx 10252 14 Sd Sd NNP cord-010092-uftc8inx 10252 15 a a DT cord-010092-uftc8inx 10252 16 -negativity -negativity NN cord-010092-uftc8inx 10252 17 and and CC cord-010092-uftc8inx 10252 18 presence presence NN cord-010092-uftc8inx 10252 19 of of IN cord-010092-uftc8inx 10252 20 antibodies antibody NNS cord-010092-uftc8inx 10252 21 will will MD cord-010092-uftc8inx 10252 22 be be VB cord-010092-uftc8inx 10252 23 performed perform VBN cord-010092-uftc8inx 10252 24 before before IN cord-010092-uftc8inx 10252 25 Sd Sd NNP cord-010092-uftc8inx 10252 26 a a DT cord-010092-uftc8inx 10252 27 can can MD cord-010092-uftc8inx 10252 28 be be VB cord-010092-uftc8inx 10252 29 assigned assign VBN cord-010092-uftc8inx 10252 30 to to IN cord-010092-uftc8inx 10252 31 a a DT cord-010092-uftc8inx 10252 32 new new JJ cord-010092-uftc8inx 10252 33 blood blood NN cord-010092-uftc8inx 10252 34 group group NN cord-010092-uftc8inx 10252 35 system system NN cord-010092-uftc8inx 10252 36 . . . cord-010092-uftc8inx 10253 1 Abstract Abstract NNP cord-010092-uftc8inx 10253 2 withdrawn withdraw VBN cord-010092-uftc8inx 10253 3 . . . cord-010092-uftc8inx 10254 1 Abstract Abstract NNP cord-010092-uftc8inx 10254 2 withdrawn withdraw VBN cord-010092-uftc8inx 10254 3 . . . cord-010092-uftc8inx 10255 1 Background background NN cord-010092-uftc8inx 10255 2 : : : cord-010092-uftc8inx 10256 1 Erythrocyte Erythrocyte NNP cord-010092-uftc8inx 10256 2 Duffy Duffy NNP cord-010092-uftc8inx 10256 3 blood blood NN cord-010092-uftc8inx 10256 4 group group NN cord-010092-uftc8inx 10256 5 antigen antigen NN cord-010092-uftc8inx 10256 6 can can MD cord-010092-uftc8inx 10256 7 scavenge scavenge VB cord-010092-uftc8inx 10256 8 chemokines chemokine NNS cord-010092-uftc8inx 10256 9 in in IN cord-010092-uftc8inx 10256 10 whole whole JJ cord-010092-uftc8inx 10256 11 blood blood NN cord-010092-uftc8inx 10256 12 . . . cord-010092-uftc8inx 10257 1 Duffy Duffy NNP cord-010092-uftc8inx 10257 2 blood blood NN cord-010092-uftc8inx 10257 3 group group NN cord-010092-uftc8inx 10257 4 gene gene NN cord-010092-uftc8inx 10257 5 consists consist VBZ cord-010092-uftc8inx 10257 6 of of IN cord-010092-uftc8inx 10257 7 two two CD cord-010092-uftc8inx 10257 8 major major JJ cord-010092-uftc8inx 10257 9 alleles allele NNS cord-010092-uftc8inx 10257 10 : : : cord-010092-uftc8inx 10258 1 FY*A FY*A NNP cord-010092-uftc8inx 10258 2 and and CC cord-010092-uftc8inx 10258 3 FY*B. FY*B. NNP cord-010092-uftc8inx 10259 1 However however RB cord-010092-uftc8inx 10259 2 , , , cord-010092-uftc8inx 10259 3 little little JJ cord-010092-uftc8inx 10259 4 is be VBZ cord-010092-uftc8inx 10259 5 known know VBN cord-010092-uftc8inx 10259 6 regarding regard VBG cord-010092-uftc8inx 10259 7 the the DT cord-010092-uftc8inx 10259 8 association association NN cord-010092-uftc8inx 10259 9 of of IN cord-010092-uftc8inx 10259 10 Duffy Duffy NNP cord-010092-uftc8inx 10259 11 blood blood NN cord-010092-uftc8inx 10259 12 group group NN cord-010092-uftc8inx 10259 13 polymorphisms polymorphism NNS cord-010092-uftc8inx 10259 14 with with IN cord-010092-uftc8inx 10259 15 the the DT cord-010092-uftc8inx 10259 16 red red JJ cord-010092-uftc8inx 10259 17 blood blood NN cord-010092-uftc8inx 10259 18 cell cell NN cord-010092-uftc8inx 10259 19 ( ( -LRB- cord-010092-uftc8inx 10259 20 RBC RBC NNP cord-010092-uftc8inx 10259 21 ) ) -RRB- cord-010092-uftc8inx 10259 22 chemokine chemokine NN cord-010092-uftc8inx 10259 23 scavenging scavenging NN cord-010092-uftc8inx 10259 24 . . . cord-010092-uftc8inx 10260 1 Aims aim VBZ cord-010092-uftc8inx 10260 2 : : : cord-010092-uftc8inx 10261 1 The the DT cord-010092-uftc8inx 10261 2 aim aim NN cord-010092-uftc8inx 10261 3 of of IN cord-010092-uftc8inx 10261 4 this this DT cord-010092-uftc8inx 10261 5 study study NN cord-010092-uftc8inx 10261 6 was be VBD cord-010092-uftc8inx 10261 7 to to TO cord-010092-uftc8inx 10261 8 determine determine VB cord-010092-uftc8inx 10261 9 the the DT cord-010092-uftc8inx 10261 10 association association NN cord-010092-uftc8inx 10261 11 of of IN cord-010092-uftc8inx 10261 12 Duffy Duffy NNP cord-010092-uftc8inx 10261 13 blood blood NN cord-010092-uftc8inx 10261 14 group group NN cord-010092-uftc8inx 10261 15 polymorphism polymorphism NN cord-010092-uftc8inx 10261 16 with with IN cord-010092-uftc8inx 10261 17 the the DT cord-010092-uftc8inx 10261 18 RBC RBC NNP cord-010092-uftc8inx 10261 19 chemokine chemokine NN cord-010092-uftc8inx 10261 20 scavenging scavenging NN cord-010092-uftc8inx 10261 21 . . . cord-010092-uftc8inx 10262 1 Methods method NNS cord-010092-uftc8inx 10262 2 : : : cord-010092-uftc8inx 10263 1 The the DT cord-010092-uftc8inx 10263 2 Duffy Duffy NNP cord-010092-uftc8inx 10263 3 blood blood NN cord-010092-uftc8inx 10263 4 group group NN cord-010092-uftc8inx 10263 5 were be VBD cord-010092-uftc8inx 10263 6 genotyped genotype VBN cord-010092-uftc8inx 10263 7 by by IN cord-010092-uftc8inx 10263 8 5ˊ-nuclease 5ˊ-nuclease CD cord-010092-uftc8inx 10263 9 assay assay NN cord-010092-uftc8inx 10263 10 in in IN cord-010092-uftc8inx 10263 11 healthy healthy JJ cord-010092-uftc8inx 10263 12 Chinese chinese JJ cord-010092-uftc8inx 10263 13 Han Han NNP cord-010092-uftc8inx 10263 14 individuals individual NNS cord-010092-uftc8inx 10263 15 , , , cord-010092-uftc8inx 10263 16 while while IN cord-010092-uftc8inx 10263 17 erythrocyte erythrocyte NN cord-010092-uftc8inx 10263 18 chemokine chemokine NN cord-010092-uftc8inx 10263 19 scavenging scavenging NN cord-010092-uftc8inx 10263 20 function function NN cord-010092-uftc8inx 10263 21 and and CC cord-010092-uftc8inx 10263 22 Duffy Duffy NNP cord-010092-uftc8inx 10263 23 antigen antigen NN cord-010092-uftc8inx 10263 24 expression expression NN cord-010092-uftc8inx 10263 25 from from IN cord-010092-uftc8inx 10263 26 the the DT cord-010092-uftc8inx 10263 27 same same JJ cord-010092-uftc8inx 10263 28 samples sample NNS cord-010092-uftc8inx 10263 29 were be VBD cord-010092-uftc8inx 10263 30 measured measure VBN cord-010092-uftc8inx 10263 31 using use VBG cord-010092-uftc8inx 10263 32 erythrocyte erythrocyte NN cord-010092-uftc8inx 10263 33 chemokine chemokine NN cord-010092-uftc8inx 10263 34 binding bind VBG cord-010092-uftc8inx 10263 35 assays assay NNS cord-010092-uftc8inx 10263 36 and and CC cord-010092-uftc8inx 10263 37 quantitative quantitative JJ cord-010092-uftc8inx 10263 38 flow flow NN cord-010092-uftc8inx 10263 39 cytometry cytometry NN cord-010092-uftc8inx 10263 40 respectively respectively RB cord-010092-uftc8inx 10263 41 . . . cord-010092-uftc8inx 10264 1 Results result NNS cord-010092-uftc8inx 10264 2 : : : cord-010092-uftc8inx 10265 1 RBC RBC NNP cord-010092-uftc8inx 10265 2 chemokine chemokine NN cord-010092-uftc8inx 10265 3 scavenging scavenging NN cord-010092-uftc8inx 10265 4 of of IN cord-010092-uftc8inx 10265 5 CXCL8 cxcl8 NN cord-010092-uftc8inx 10265 6 was be VBD cord-010092-uftc8inx 10265 7 significantly significantly RB cord-010092-uftc8inx 10265 8 lower low JJR cord-010092-uftc8inx 10265 9 in in IN cord-010092-uftc8inx 10265 10 the the DT cord-010092-uftc8inx 10265 11 individuals individual NNS cord-010092-uftc8inx 10265 12 with with IN cord-010092-uftc8inx 10265 13 the the DT cord-010092-uftc8inx 10265 14 FY*A FY*A NNP cord-010092-uftc8inx 10265 15 / / SYM cord-010092-uftc8inx 10265 16 FY*A FY*A NNP cord-010092-uftc8inx 10265 17 genotype genotype NN cord-010092-uftc8inx 10265 18 compared compare VBN cord-010092-uftc8inx 10265 19 to to IN cord-010092-uftc8inx 10265 20 those those DT cord-010092-uftc8inx 10265 21 with with IN cord-010092-uftc8inx 10265 22 FY*A FY*A NNP cord-010092-uftc8inx 10265 23 / / SYM cord-010092-uftc8inx 10265 24 FY*B FY*B NNP cord-010092-uftc8inx 10265 25 genotype genotype NN cord-010092-uftc8inx 10265 26 ( ( -LRB- cord-010092-uftc8inx 10265 27 P p NN cord-010092-uftc8inx 10265 28 = = SYM cord-010092-uftc8inx 10265 29 0.016 0.016 CD cord-010092-uftc8inx 10265 30 ) ) -RRB- cord-010092-uftc8inx 10265 31 . . . cord-010092-uftc8inx 10266 1 Similar similar JJ cord-010092-uftc8inx 10266 2 result result NN cord-010092-uftc8inx 10266 3 was be VBD cord-010092-uftc8inx 10266 4 also also RB cord-010092-uftc8inx 10266 5 observed observe VBN cord-010092-uftc8inx 10266 6 in in IN cord-010092-uftc8inx 10266 7 RBC RBC NNP cord-010092-uftc8inx 10266 8 chemokine chemokine NN cord-010092-uftc8inx 10266 9 scavenging scavenging NN cord-010092-uftc8inx 10266 10 of of IN cord-010092-uftc8inx 10266 11 CCL2 CCL2 NNP cord-010092-uftc8inx 10266 12 ( ( -LRB- cord-010092-uftc8inx 10266 13 P p NN cord-010092-uftc8inx 10266 14 = = SYM cord-010092-uftc8inx 10266 15 0.038 0.038 CD cord-010092-uftc8inx 10266 16 ) ) -RRB- cord-010092-uftc8inx 10266 17 . . . cord-010092-uftc8inx 10267 1 The the DT cord-010092-uftc8inx 10267 2 expression expression NN cord-010092-uftc8inx 10267 3 of of IN cord-010092-uftc8inx 10267 4 Duffy Duffy NNP cord-010092-uftc8inx 10267 5 antigen antigen NN cord-010092-uftc8inx 10267 6 on on IN cord-010092-uftc8inx 10267 7 RBC RBC NNP cord-010092-uftc8inx 10267 8 surface surface NN cord-010092-uftc8inx 10267 9 in in IN cord-010092-uftc8inx 10267 10 the the DT cord-010092-uftc8inx 10267 11 individuals individual NNS cord-010092-uftc8inx 10267 12 with with IN cord-010092-uftc8inx 10267 13 the the DT cord-010092-uftc8inx 10267 14 FY*A FY*A NNP cord-010092-uftc8inx 10267 15 / / SYM cord-010092-uftc8inx 10267 16 FY*A FY*A NNP cord-010092-uftc8inx 10267 17 genotype genotype NN cord-010092-uftc8inx 10267 18 was be VBD cord-010092-uftc8inx 10267 19 significantly significantly RB cord-010092-uftc8inx 10267 20 higher high JJR cord-010092-uftc8inx 10267 21 compared compare VBN cord-010092-uftc8inx 10267 22 to to IN cord-010092-uftc8inx 10267 23 those those DT cord-010092-uftc8inx 10267 24 with with IN cord-010092-uftc8inx 10267 25 FY*A/ fy*a/ JJ cord-010092-uftc8inx 10267 26 FY*B FY*B NNP cord-010092-uftc8inx 10267 27 genotype genotype NN cord-010092-uftc8inx 10267 28 ( ( -LRB- cord-010092-uftc8inx 10267 29 P p NN cord-010092-uftc8inx 10267 30 = = SYM cord-010092-uftc8inx 10267 31 0.021 0.021 CD cord-010092-uftc8inx 10267 32 ) ) -RRB- cord-010092-uftc8inx 10267 33 . . . cord-010092-uftc8inx 10268 1 Summary Summary NNP cord-010092-uftc8inx 10268 2 / / SYM cord-010092-uftc8inx 10268 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 10268 4 : : : cord-010092-uftc8inx 10269 1 Duffy Duffy NNP cord-010092-uftc8inx 10269 2 blood blood NN cord-010092-uftc8inx 10269 3 group group NN cord-010092-uftc8inx 10269 4 polymorphism polymorphism NN cord-010092-uftc8inx 10269 5 is be VBZ cord-010092-uftc8inx 10269 6 associated associate VBN cord-010092-uftc8inx 10269 7 with with IN cord-010092-uftc8inx 10269 8 the the DT cord-010092-uftc8inx 10269 9 differential differential JJ cord-010092-uftc8inx 10269 10 RBC RBC NNP cord-010092-uftc8inx 10269 11 chemokine chemokine NN cord-010092-uftc8inx 10269 12 scavenging scavenging NN cord-010092-uftc8inx 10269 13 . . . cord-010092-uftc8inx 10270 1 It -PRON- PRP cord-010092-uftc8inx 10270 2 is be VBZ cord-010092-uftc8inx 10270 3 probable probable JJ cord-010092-uftc8inx 10270 4 that that IN cord-010092-uftc8inx 10270 5 a a DT cord-010092-uftc8inx 10270 6 change change NN cord-010092-uftc8inx 10270 7 in in IN cord-010092-uftc8inx 10270 8 Duffy Duffy NNP cord-010092-uftc8inx 10270 9 antigen antigen NN cord-010092-uftc8inx 10270 10 structure structure NN cord-010092-uftc8inx 10270 11 caused cause VBN cord-010092-uftc8inx 10270 12 by by IN cord-010092-uftc8inx 10270 13 Duffy Duffy NNP cord-010092-uftc8inx 10270 14 blood blood NN cord-010092-uftc8inx 10270 15 group group NN cord-010092-uftc8inx 10270 16 polymorphism polymorphism NN cord-010092-uftc8inx 10270 17 is be VBZ cord-010092-uftc8inx 10270 18 responsible responsible JJ cord-010092-uftc8inx 10270 19 for for IN cord-010092-uftc8inx 10270 20 the the DT cord-010092-uftc8inx 10270 21 differential differential JJ cord-010092-uftc8inx 10270 22 RBC RBC NNP cord-010092-uftc8inx 10270 23 chemokine chemokine NN cord-010092-uftc8inx 10270 24 scavenging scavenging NN cord-010092-uftc8inx 10270 25 . . . cord-010092-uftc8inx 10271 1 Background background NN cord-010092-uftc8inx 10271 2 : : : cord-010092-uftc8inx 10272 1 Individuals individual NNS cord-010092-uftc8inx 10272 2 with with IN cord-010092-uftc8inx 10272 3 p p NN cord-010092-uftc8inx 10272 4 - - HYPH cord-010092-uftc8inx 10272 5 phenotype phenotype NN cord-010092-uftc8inx 10272 6 can can MD cord-010092-uftc8inx 10272 7 develop develop VB cord-010092-uftc8inx 10272 8 a a DT cord-010092-uftc8inx 10272 9 naturally naturally RB cord-010092-uftc8inx 10272 10 occurring occur VBG cord-010092-uftc8inx 10272 11 anti anti JJ cord-010092-uftc8inx 10272 12 - - JJ cord-010092-uftc8inx 10272 13 PP1Pk PP1Pk NNP cord-010092-uftc8inx 10272 14 and and CC cord-010092-uftc8inx 10272 15 has have VBZ cord-010092-uftc8inx 10272 16 clinical clinical JJ cord-010092-uftc8inx 10272 17 significance significance NN cord-010092-uftc8inx 10272 18 , , , cord-010092-uftc8inx 10272 19 causing cause VBG cord-010092-uftc8inx 10272 20 hemolytic hemolytic JJ cord-010092-uftc8inx 10272 21 transfusion transfusion NN cord-010092-uftc8inx 10272 22 reactions reaction NNS cord-010092-uftc8inx 10272 23 or or CC cord-010092-uftc8inx 10272 24 hemolytic hemolytic JJ cord-010092-uftc8inx 10272 25 disease disease NN cord-010092-uftc8inx 10272 26 of of IN cord-010092-uftc8inx 10272 27 the the DT cord-010092-uftc8inx 10272 28 fetus fetus NN cord-010092-uftc8inx 10272 29 and and CC cord-010092-uftc8inx 10272 30 newborn newborn JJ cord-010092-uftc8inx 10272 31 . . . cord-010092-uftc8inx 10273 1 Finding find VBG cord-010092-uftc8inx 10273 2 and and CC cord-010092-uftc8inx 10273 3 procuring procure VBG cord-010092-uftc8inx 10273 4 blood blood NN cord-010092-uftc8inx 10273 5 units unit NNS cord-010092-uftc8inx 10273 6 of of IN cord-010092-uftc8inx 10273 7 pphenotype pphenotype NNP cord-010092-uftc8inx 10273 8 is be VBZ cord-010092-uftc8inx 10273 9 a a DT cord-010092-uftc8inx 10273 10 challenge challenge NN cord-010092-uftc8inx 10273 11 because because IN cord-010092-uftc8inx 10273 12 of of IN cord-010092-uftc8inx 10273 13 its -PRON- PRP$ cord-010092-uftc8inx 10273 14 rarity rarity NN cord-010092-uftc8inx 10273 15 throughout throughout IN cord-010092-uftc8inx 10273 16 the the DT cord-010092-uftc8inx 10273 17 world world NN cord-010092-uftc8inx 10273 18 . . . cord-010092-uftc8inx 10274 1 Therefore therefore RB cord-010092-uftc8inx 10274 2 , , , cord-010092-uftc8inx 10274 3 acute acute JJ cord-010092-uftc8inx 10274 4 normovolemic normovolemic JJ cord-010092-uftc8inx 10274 5 hemodilution hemodilution NNP cord-010092-uftc8inx 10274 6 ( ( -LRB- cord-010092-uftc8inx 10274 7 ANH ANH NNP cord-010092-uftc8inx 10274 8 ) ) -RRB- cord-010092-uftc8inx 10274 9 can can MD cord-010092-uftc8inx 10274 10 be be VB cord-010092-uftc8inx 10274 11 an an DT cord-010092-uftc8inx 10274 12 on on IN cord-010092-uftc8inx 10274 13 hand hand NN cord-010092-uftc8inx 10274 14 tool tool NN cord-010092-uftc8inx 10274 15 in in IN cord-010092-uftc8inx 10274 16 the the DT cord-010092-uftc8inx 10274 17 perioperative perioperative JJ cord-010092-uftc8inx 10274 18 successful successful JJ cord-010092-uftc8inx 10274 19 management management NN cord-010092-uftc8inx 10274 20 of of IN cord-010092-uftc8inx 10274 21 patient patient NN cord-010092-uftc8inx 10274 22 with with IN cord-010092-uftc8inx 10274 23 rare rare JJ cord-010092-uftc8inx 10274 24 blood blood NN cord-010092-uftc8inx 10274 25 group group NN cord-010092-uftc8inx 10274 26 . . . cord-010092-uftc8inx 10275 1 However however RB cord-010092-uftc8inx 10275 2 , , , cord-010092-uftc8inx 10275 3 this this DT cord-010092-uftc8inx 10275 4 approach approach NN cord-010092-uftc8inx 10275 5 has have VBZ cord-010092-uftc8inx 10275 6 not not RB cord-010092-uftc8inx 10275 7 been be VBN cord-010092-uftc8inx 10275 8 commonly commonly RB cord-010092-uftc8inx 10275 9 used use VBN cord-010092-uftc8inx 10275 10 Aims aim NNS cord-010092-uftc8inx 10275 11 : : : cord-010092-uftc8inx 10276 1 N n NN cord-010092-uftc8inx 10276 2 / / SYM cord-010092-uftc8inx 10276 3 A. a. NN cord-010092-uftc8inx 10276 4 Methods method NNS cord-010092-uftc8inx 10276 5 : : : cord-010092-uftc8inx 10277 1 N n NN cord-010092-uftc8inx 10277 2 / / SYM cord-010092-uftc8inx 10277 3 A. a. NN cord-010092-uftc8inx 10277 4 Results result NNS cord-010092-uftc8inx 10277 5 : : : cord-010092-uftc8inx 10278 1 A a DT cord-010092-uftc8inx 10278 2 66-year 66-year JJ cord-010092-uftc8inx 10278 3 - - HYPH cord-010092-uftc8inx 10278 4 old old JJ cord-010092-uftc8inx 10278 5 Korean korean JJ cord-010092-uftc8inx 10278 6 woman woman NN cord-010092-uftc8inx 10278 7 was be VBD cord-010092-uftc8inx 10278 8 referred refer VBN cord-010092-uftc8inx 10278 9 to to IN cord-010092-uftc8inx 10278 10 Samsung Samsung NNP cord-010092-uftc8inx 10278 11 Medical Medical NNP cord-010092-uftc8inx 10278 12 Center Center NNP cord-010092-uftc8inx 10278 13 for for IN cord-010092-uftc8inx 10278 14 surgical surgical JJ cord-010092-uftc8inx 10278 15 management management NN cord-010092-uftc8inx 10278 16 for for IN cord-010092-uftc8inx 10278 17 gallbladder gallbladder NN cord-010092-uftc8inx 10278 18 malignancy malignancy NN cord-010092-uftc8inx 10278 19 . . . cord-010092-uftc8inx 10279 1 Her -PRON- PRP$ cord-010092-uftc8inx 10279 2 blood blood NN cord-010092-uftc8inx 10279 3 type type NN cord-010092-uftc8inx 10279 4 was be VBD cord-010092-uftc8inx 10279 5 group group NN cord-010092-uftc8inx 10279 6 A A NNP cord-010092-uftc8inx 10279 7 , , , cord-010092-uftc8inx 10279 8 D d NN cord-010092-uftc8inx 10279 9 - - HYPH cord-010092-uftc8inx 10279 10 positive positive JJ cord-010092-uftc8inx 10279 11 . . . cord-010092-uftc8inx 10280 1 The the DT cord-010092-uftc8inx 10280 2 patient patient NN cord-010092-uftc8inx 10280 3 had have VBD cord-010092-uftc8inx 10280 4 no no DT cord-010092-uftc8inx 10280 5 known know VBN cord-010092-uftc8inx 10280 6 history history NN cord-010092-uftc8inx 10280 7 of of IN cord-010092-uftc8inx 10280 8 transfusion transfusion NN cord-010092-uftc8inx 10280 9 . . . cord-010092-uftc8inx 10281 1 However however RB cord-010092-uftc8inx 10281 2 , , , cord-010092-uftc8inx 10281 3 antibody antibody NN cord-010092-uftc8inx 10281 4 screening screening NN cord-010092-uftc8inx 10281 5 and and CC cord-010092-uftc8inx 10281 6 identification identification NN cord-010092-uftc8inx 10281 7 test test NN cord-010092-uftc8inx 10281 8 using use VBG cord-010092-uftc8inx 10281 9 the the DT cord-010092-uftc8inx 10281 10 column column NN cord-010092-uftc8inx 10281 11 agglutination agglutination NN cord-010092-uftc8inx 10281 12 method method NN cord-010092-uftc8inx 10281 13 ( ( -LRB- cord-010092-uftc8inx 10281 14 Bio Bio NNP cord-010092-uftc8inx 10281 15 - - HYPH cord-010092-uftc8inx 10281 16 Rad Rad NNP cord-010092-uftc8inx 10281 17 , , , cord-010092-uftc8inx 10281 18 Cressier Cressier NNP cord-010092-uftc8inx 10281 19 , , , cord-010092-uftc8inx 10281 20 Switzerland Switzerland NNP cord-010092-uftc8inx 10281 21 ) ) -RRB- cord-010092-uftc8inx 10281 22 showed show VBD cord-010092-uftc8inx 10281 23 panagglutination panagglutination NN cord-010092-uftc8inx 10281 24 with with IN cord-010092-uftc8inx 10281 25 negative negative JJ cord-010092-uftc8inx 10281 26 reactions reaction NNS cord-010092-uftc8inx 10281 27 to to IN cord-010092-uftc8inx 10281 28 autologous autologous JJ cord-010092-uftc8inx 10281 29 red red JJ cord-010092-uftc8inx 10281 30 blood blood NN cord-010092-uftc8inx 10281 31 cells cell NNS cord-010092-uftc8inx 10281 32 , , , cord-010092-uftc8inx 10281 33 indicating indicate VBG cord-010092-uftc8inx 10281 34 the the DT cord-010092-uftc8inx 10281 35 presence presence NN cord-010092-uftc8inx 10281 36 of of IN cord-010092-uftc8inx 10281 37 alloantibodies alloantibody NNS cord-010092-uftc8inx 10281 38 to to IN cord-010092-uftc8inx 10281 39 high high JJ cord-010092-uftc8inx 10281 40 frequency frequency NN cord-010092-uftc8inx 10281 41 antigens antigen NNS cord-010092-uftc8inx 10281 42 . . . cord-010092-uftc8inx 10282 1 The the DT cord-010092-uftc8inx 10282 2 specimen specimen NN cord-010092-uftc8inx 10282 3 obtained obtain VBN cord-010092-uftc8inx 10282 4 from from IN cord-010092-uftc8inx 10282 5 the the DT cord-010092-uftc8inx 10282 6 patient patient NN cord-010092-uftc8inx 10282 7 was be VBD cord-010092-uftc8inx 10282 8 sent send VBN cord-010092-uftc8inx 10282 9 to to IN cord-010092-uftc8inx 10282 10 the the DT cord-010092-uftc8inx 10282 11 central central JJ cord-010092-uftc8inx 10282 12 laboratory laboratory NN cord-010092-uftc8inx 10282 13 of of IN cord-010092-uftc8inx 10282 14 the the DT cord-010092-uftc8inx 10282 15 Swiss Swiss NNP cord-010092-uftc8inx 10282 16 Red Red NNP cord-010092-uftc8inx 10282 17 Cross Cross NNP cord-010092-uftc8inx 10282 18 ( ( -LRB- cord-010092-uftc8inx 10282 19 Bern Bern NNP cord-010092-uftc8inx 10282 20 , , , cord-010092-uftc8inx 10282 21 Switzerland Switzerland NNP cord-010092-uftc8inx 10282 22 ) ) -RRB- cord-010092-uftc8inx 10282 23 and and CC cord-010092-uftc8inx 10282 24 confirmed confirm VBD cord-010092-uftc8inx 10282 25 as as IN cord-010092-uftc8inx 10282 26 anti anti NNP cord-010092-uftc8inx 10282 27 - - JJ cord-010092-uftc8inx 10282 28 PP1Pk PP1Pk NNP cord-010092-uftc8inx 10282 29 . . . cord-010092-uftc8inx 10283 1 At at IN cord-010092-uftc8inx 10283 2 first first RB cord-010092-uftc8inx 10283 3 , , , cord-010092-uftc8inx 10283 4 the the DT cord-010092-uftc8inx 10283 5 transfusion transfusion NN cord-010092-uftc8inx 10283 6 team team NN cord-010092-uftc8inx 10283 7 of of IN cord-010092-uftc8inx 10283 8 our -PRON- PRP$ cord-010092-uftc8inx 10283 9 hospital hospital NN cord-010092-uftc8inx 10283 10 recommended recommend VBD cord-010092-uftc8inx 10283 11 the the DT cord-010092-uftc8inx 10283 12 surgical surgical JJ cord-010092-uftc8inx 10283 13 team team NN cord-010092-uftc8inx 10283 14 to to TO cord-010092-uftc8inx 10283 15 postpone postpone VB cord-010092-uftc8inx 10283 16 the the DT cord-010092-uftc8inx 10283 17 surgery surgery NN cord-010092-uftc8inx 10283 18 . . . cord-010092-uftc8inx 10284 1 However however RB cord-010092-uftc8inx 10284 2 , , , cord-010092-uftc8inx 10284 3 ANH ANH NNP cord-010092-uftc8inx 10284 4 was be VBD cord-010092-uftc8inx 10284 5 planned plan VBN cord-010092-uftc8inx 10284 6 because because IN cord-010092-uftc8inx 10284 7 postponing postpone VBG cord-010092-uftc8inx 10284 8 surgery surgery NN cord-010092-uftc8inx 10284 9 was be VBD cord-010092-uftc8inx 10284 10 not not RB cord-010092-uftc8inx 10284 11 preferred prefer VBN cord-010092-uftc8inx 10284 12 and and CC cord-010092-uftc8inx 10284 13 the the DT cord-010092-uftc8inx 10284 14 patient patient NN cord-010092-uftc8inx 10284 15 's 's POS cord-010092-uftc8inx 10284 16 preoperative preoperative JJ cord-010092-uftc8inx 10284 17 hemoglobin hemoglobin NN cord-010092-uftc8inx 10284 18 was be VBD cord-010092-uftc8inx 10284 19 12.9 12.9 CD cord-010092-uftc8inx 10284 20 g g NNP cord-010092-uftc8inx 10284 21 / / SYM cord-010092-uftc8inx 10284 22 dl dl NN cord-010092-uftc8inx 10284 23 . . . cord-010092-uftc8inx 10285 1 800 800 CD cord-010092-uftc8inx 10285 2 mL ml NN cord-010092-uftc8inx 10285 3 of of IN cord-010092-uftc8inx 10285 4 blood blood NN cord-010092-uftc8inx 10285 5 was be VBD cord-010092-uftc8inx 10285 6 withdrawn withdraw VBN cord-010092-uftc8inx 10285 7 through through IN cord-010092-uftc8inx 10285 8 a a DT cord-010092-uftc8inx 10285 9 radial radial JJ cord-010092-uftc8inx 10285 10 arterial arterial JJ cord-010092-uftc8inx 10285 11 catheter catheter NN cord-010092-uftc8inx 10285 12 in in IN cord-010092-uftc8inx 10285 13 two two CD cord-010092-uftc8inx 10285 14 400 400 CD cord-010092-uftc8inx 10285 15 mL ml NN cord-010092-uftc8inx 10285 16 blood blood NN cord-010092-uftc8inx 10285 17 bags bag NNS cord-010092-uftc8inx 10285 18 containing contain VBG cord-010092-uftc8inx 10285 19 citrate citrate NN cord-010092-uftc8inx 10285 20 - - HYPH cord-010092-uftc8inx 10285 21 phosphate phosphate NN cord-010092-uftc8inx 10285 22 - - HYPH cord-010092-uftc8inx 10285 23 dextrose dextrose NN cord-010092-uftc8inx 10285 24 - - HYPH cord-010092-uftc8inx 10285 25 A a DT cord-010092-uftc8inx 10285 26 solution solution NN cord-010092-uftc8inx 10285 27 after after IN cord-010092-uftc8inx 10285 28 anesthetic anesthetic JJ cord-010092-uftc8inx 10285 29 induction induction NN cord-010092-uftc8inx 10285 30 . . . cord-010092-uftc8inx 10286 1 Equal equal JJ cord-010092-uftc8inx 10286 2 volume volume NN cord-010092-uftc8inx 10286 3 of of IN cord-010092-uftc8inx 10286 4 6 6 CD cord-010092-uftc8inx 10286 5 % % NN cord-010092-uftc8inx 10286 6 hydroxyethyl hydroxyethyl NN cord-010092-uftc8inx 10286 7 starch starch NN cord-010092-uftc8inx 10286 8 solution solution NN cord-010092-uftc8inx 10286 9 was be VBD cord-010092-uftc8inx 10286 10 infused infuse VBN cord-010092-uftc8inx 10286 11 during during IN cord-010092-uftc8inx 10286 12 the the DT cord-010092-uftc8inx 10286 13 procedure procedure NN cord-010092-uftc8inx 10286 14 . . . cord-010092-uftc8inx 10287 1 The the DT cord-010092-uftc8inx 10287 2 patient patient NN cord-010092-uftc8inx 10287 3 underwent undergo VBD cord-010092-uftc8inx 10287 4 radical radical JJ cord-010092-uftc8inx 10287 5 cholecystectomy cholecystectomy NN cord-010092-uftc8inx 10287 6 and and CC cord-010092-uftc8inx 10287 7 liver liver NN cord-010092-uftc8inx 10287 8 wedge wedge NN cord-010092-uftc8inx 10287 9 resection resection NN cord-010092-uftc8inx 10287 10 with with IN cord-010092-uftc8inx 10287 11 lymph lymph NN cord-010092-uftc8inx 10287 12 node node NN cord-010092-uftc8inx 10287 13 dissection dissection NN cord-010092-uftc8inx 10287 14 , , , cord-010092-uftc8inx 10287 15 and and CC cord-010092-uftc8inx 10287 16 two two CD cord-010092-uftc8inx 10287 17 units unit NNS cord-010092-uftc8inx 10287 18 of of IN cord-010092-uftc8inx 10287 19 autologous autologous JJ cord-010092-uftc8inx 10287 20 blood blood NN cord-010092-uftc8inx 10287 21 were be VBD cord-010092-uftc8inx 10287 22 returned return VBN cord-010092-uftc8inx 10287 23 to to IN cord-010092-uftc8inx 10287 24 the the DT cord-010092-uftc8inx 10287 25 patient patient NN cord-010092-uftc8inx 10287 26 during during IN cord-010092-uftc8inx 10287 27 surgery surgery NN cord-010092-uftc8inx 10287 28 . . . cord-010092-uftc8inx 10288 1 She -PRON- PRP cord-010092-uftc8inx 10288 2 was be VBD cord-010092-uftc8inx 10288 3 then then RB cord-010092-uftc8inx 10288 4 discharged discharge VBN cord-010092-uftc8inx 10288 5 48 48 CD cord-010092-uftc8inx 10288 6 h h NN cord-010092-uftc8inx 10288 7 later later RB cord-010092-uftc8inx 10288 8 with with IN cord-010092-uftc8inx 10288 9 a a DT cord-010092-uftc8inx 10288 10 hemoglobin hemoglobin NN cord-010092-uftc8inx 10288 11 level level NN cord-010092-uftc8inx 10288 12 of of IN cord-010092-uftc8inx 10288 13 12.3 12.3 CD cord-010092-uftc8inx 10288 14 g g NN cord-010092-uftc8inx 10288 15 / / SYM cord-010092-uftc8inx 10288 16 dL. dL. NNP cord-010092-uftc8inx 10289 1 Later later RBR cord-010092-uftc8inx 10289 2 , , , cord-010092-uftc8inx 10289 3 the the DT cord-010092-uftc8inx 10289 4 family family NN cord-010092-uftc8inx 10289 5 study study NN cord-010092-uftc8inx 10289 6 was be VBD cord-010092-uftc8inx 10289 7 performed perform VBN cord-010092-uftc8inx 10289 8 with with IN cord-010092-uftc8inx 10289 9 the the DT cord-010092-uftc8inx 10289 10 standard standard JJ cord-010092-uftc8inx 10289 11 serologic serologic NN cord-010092-uftc8inx 10289 12 method method NN cord-010092-uftc8inx 10289 13 using use VBG cord-010092-uftc8inx 10289 14 the the DT cord-010092-uftc8inx 10289 15 proband proband NN cord-010092-uftc8inx 10289 16 's 's POS cord-010092-uftc8inx 10289 17 plasma plasma NN cord-010092-uftc8inx 10289 18 containing contain VBG cord-010092-uftc8inx 10289 19 anti anti NNP cord-010092-uftc8inx 10289 20 - - JJ cord-010092-uftc8inx 10289 21 PP1Pk PP1Pk NNP cord-010092-uftc8inx 10289 22 and and CC cord-010092-uftc8inx 10289 23 sequencing sequencing NN cord-010092-uftc8inx 10289 24 of of IN cord-010092-uftc8inx 10289 25 the the DT cord-010092-uftc8inx 10289 26 A4GALT A4GALT NNP cord-010092-uftc8inx 10289 27 gene gene NN cord-010092-uftc8inx 10289 28 , , , cord-010092-uftc8inx 10289 29 which which WDT cord-010092-uftc8inx 10289 30 were be VBD cord-010092-uftc8inx 10289 31 conducted conduct VBN cord-010092-uftc8inx 10289 32 according accord VBG cord-010092-uftc8inx 10289 33 to to IN cord-010092-uftc8inx 10289 34 the the DT cord-010092-uftc8inx 10289 35 protocols protocol NNS cord-010092-uftc8inx 10289 36 by by IN cord-010092-uftc8inx 10289 37 Koda Koda NNP cord-010092-uftc8inx 10289 38 et et NNP cord-010092-uftc8inx 10289 39 al.(Transfusion al.(Transfusion NNP cord-010092-uftc8inx 10289 40 . . . cord-010092-uftc8inx 10290 1 2002 2002 CD cord-010092-uftc8inx 10290 2 ) ) -RRB- cord-010092-uftc8inx 10290 3 . . . cord-010092-uftc8inx 10291 1 The the DT cord-010092-uftc8inx 10291 2 proband proband NN cord-010092-uftc8inx 10291 3 and and CC cord-010092-uftc8inx 10291 4 her -PRON- PRP$ cord-010092-uftc8inx 10291 5 brother brother NN cord-010092-uftc8inx 10291 6 were be VBD cord-010092-uftc8inx 10291 7 homozygous homozygous JJ cord-010092-uftc8inx 10291 8 for for IN cord-010092-uftc8inx 10291 9 c.1029dupC c.1029dupC NNP cord-010092-uftc8inx 10291 10 , , , cord-010092-uftc8inx 10291 11 indicating indicate VBG cord-010092-uftc8inx 10291 12 a a DT cord-010092-uftc8inx 10291 13 rare rare JJ cord-010092-uftc8inx 10291 14 p p NN cord-010092-uftc8inx 10291 15 phenotype phenotype NN cord-010092-uftc8inx 10291 16 . . . cord-010092-uftc8inx 10292 1 Summary Summary NNP cord-010092-uftc8inx 10292 2 / / SYM cord-010092-uftc8inx 10292 3 Conclusions conclusion NNS cord-010092-uftc8inx 10292 4 : : : cord-010092-uftc8inx 10292 5 We -PRON- PRP cord-010092-uftc8inx 10292 6 experienced experience VBD cord-010092-uftc8inx 10292 7 that that IN cord-010092-uftc8inx 10292 8 autologous autologous JJ cord-010092-uftc8inx 10292 9 blood blood NN cord-010092-uftc8inx 10292 10 transfusions transfusion NNS cord-010092-uftc8inx 10292 11 via via IN cord-010092-uftc8inx 10292 12 ANH ANH NNP cord-010092-uftc8inx 10292 13 is be VBZ cord-010092-uftc8inx 10292 14 an an DT cord-010092-uftc8inx 10292 15 alternative alternative NN cord-010092-uftc8inx 10292 16 to to IN cord-010092-uftc8inx 10292 17 allogenic allogenic JJ cord-010092-uftc8inx 10292 18 RBC RBC NNP cord-010092-uftc8inx 10292 19 blood blood NN cord-010092-uftc8inx 10292 20 transfusion transfusion NN cord-010092-uftc8inx 10292 21 in in IN cord-010092-uftc8inx 10292 22 patients patient NNS cord-010092-uftc8inx 10292 23 who who WP cord-010092-uftc8inx 10292 24 have have VBP cord-010092-uftc8inx 10292 25 no no DT cord-010092-uftc8inx 10292 26 blood blood NN cord-010092-uftc8inx 10292 27 available available JJ cord-010092-uftc8inx 10292 28 because because IN cord-010092-uftc8inx 10292 29 of of IN cord-010092-uftc8inx 10292 30 high high JJ cord-010092-uftc8inx 10292 31 alloimmunization alloimmunization NN cord-010092-uftc8inx 10292 32 antibodies antibody NNS cord-010092-uftc8inx 10292 33 against against IN cord-010092-uftc8inx 10292 34 rare rare JJ cord-010092-uftc8inx 10292 35 blood blood NN cord-010092-uftc8inx 10292 36 groups group NNS cord-010092-uftc8inx 10292 37 . . . cord-010092-uftc8inx 10292 38 " " '' cord-010092-uftc8inx 10293 1 and and CC cord-010092-uftc8inx 10293 2 the the DT cord-010092-uftc8inx 10293 3 third third JJ cord-010092-uftc8inx 10293 4 sample sample NN cord-010092-uftc8inx 10293 5 as as IN cord-010092-uftc8inx 10293 6 " " `` cord-010092-uftc8inx 10293 7 GYPB*S_GYP*[140A GYPB*S_GYP*[140A NNP cord-010092-uftc8inx 10293 8 ] ] -RRB- cord-010092-uftc8inx 10293 9 , , , cord-010092-uftc8inx 10293 10 GYPB*S_null(IVS5 GYPB*S_null(IVS5 VBN cord-010092-uftc8inx 10293 11 + + SYM cord-010092-uftc8inx 10293 12 5 5 CD cord-010092-uftc8inx 10293 13 t t NN cord-010092-uftc8inx 10293 14 ) ) -RRB- cord-010092-uftc8inx 10294 1 " " `` cord-010092-uftc8inx 10294 2 with with IN cord-010092-uftc8inx 10294 3 a a DT cord-010092-uftc8inx 10294 4 predicted predict VBN cord-010092-uftc8inx 10294 5 phenotype phenotype NN cord-010092-uftc8inx 10294 6 : : : cord-010092-uftc8inx 10294 7 S S NNP cord-010092-uftc8inx 10294 8 - - HYPH cord-010092-uftc8inx 10294 9 s+ s+ NNP cord-010092-uftc8inx 10294 10 Mi Mi NNPS cord-010092-uftc8inx 10295 1 a a LS cord-010092-uftc8inx 10295 2 + + NN cord-010092-uftc8inx 10295 3 and and CC cord-010092-uftc8inx 10296 1 S+s S+s NNP cord-010092-uftc8inx 10296 2 - - HYPH cord-010092-uftc8inx 10296 3 Mi Mi NNP cord-010092-uftc8inx 10297 1 a a LS cord-010092-uftc8inx 10297 2 + + NN cord-010092-uftc8inx 10297 3 , , , cord-010092-uftc8inx 10297 4 respectively respectively RB cord-010092-uftc8inx 10297 5 . . . cord-010092-uftc8inx 10298 1 The the DT cord-010092-uftc8inx 10298 2 GYPA GYPA NNP cord-010092-uftc8inx 10298 3 specific specific JJ cord-010092-uftc8inx 10298 4 primers primer NNS cord-010092-uftc8inx 10298 5 used use VBN cord-010092-uftc8inx 10298 6 for for IN cord-010092-uftc8inx 10298 7 discrepancy discrepancy NN cord-010092-uftc8inx 10298 8 resolution resolution NN cord-010092-uftc8inx 10298 9 detected detect VBD cord-010092-uftc8inx 10298 10 the the DT cord-010092-uftc8inx 10298 11 nucleotide nucleotide JJ cord-010092-uftc8inx 10298 12 substitution substitution NN cord-010092-uftc8inx 10298 13 , , , cord-010092-uftc8inx 10298 14 GYP.c.140C GYP.c.140C NNP cord-010092-uftc8inx 10299 1 > > XX cord-010092-uftc8inx 10300 1 A a LS cord-010092-uftc8inx 10300 2 , , , cord-010092-uftc8inx 10300 3 in in IN cord-010092-uftc8inx 10300 4 GYPA GYPA NNP cord-010092-uftc8inx 10300 5 - - HYPH cord-010092-uftc8inx 10300 6 B B NNP cord-010092-uftc8inx 10300 7 - - HYPH cord-010092-uftc8inx 10300 8 A a DT cord-010092-uftc8inx 10300 9 hybrid hybrid NN cord-010092-uftc8inx 10300 10 associated associate VBN cord-010092-uftc8inx 10300 11 to to IN cord-010092-uftc8inx 10300 12 GP.Hut GP.Hut NNP cord-010092-uftc8inx 10300 13 allele allele NN cord-010092-uftc8inx 10300 14 , , , cord-010092-uftc8inx 10300 15 thus thus RB cord-010092-uftc8inx 10300 16 confirming confirm VBG cord-010092-uftc8inx 10300 17 the the DT cord-010092-uftc8inx 10300 18 ID ID NNP cord-010092-uftc8inx 10300 19 CORE CORE NNP cord-010092-uftc8inx 10300 20 XT XT NNP cord-010092-uftc8inx 10300 21 result result NN cord-010092-uftc8inx 10300 22 . . . cord-010092-uftc8inx 10301 1 The the DT cord-010092-uftc8inx 10301 2 expression expression NN cord-010092-uftc8inx 10301 3 of of IN cord-010092-uftc8inx 10301 4 Mi Mi NNP cord-010092-uftc8inx 10301 5 a a DT cord-010092-uftc8inx 10301 6 for for IN cord-010092-uftc8inx 10301 7 one one CD cord-010092-uftc8inx 10301 8 of of IN cord-010092-uftc8inx 10301 9 these these DT cord-010092-uftc8inx 10301 10 samples sample NNS cord-010092-uftc8inx 10301 11 was be VBD cord-010092-uftc8inx 10301 12 confirmed confirm VBN cord-010092-uftc8inx 10301 13 using use VBG cord-010092-uftc8inx 10301 14 non non JJ cord-010092-uftc8inx 10301 15 - - JJ cord-010092-uftc8inx 10301 16 commercial commercial JJ cord-010092-uftc8inx 10301 17 anti anti JJ cord-010092-uftc8inx 10301 18 - - JJ cord-010092-uftc8inx 10301 19 sera sera JJ cord-010092-uftc8inx 10301 20 . . . cord-010092-uftc8inx 10302 1 Hence hence RB cord-010092-uftc8inx 10302 2 , , , cord-010092-uftc8inx 10302 3 these these DT cord-010092-uftc8inx 10302 4 three three CD cord-010092-uftc8inx 10302 5 samples sample NNS cord-010092-uftc8inx 10302 6 were be VBD cord-010092-uftc8inx 10302 7 not not RB cord-010092-uftc8inx 10302 8 GP.Mur GP.Mur NNP cord-010092-uftc8inx 10302 9 but but CC cord-010092-uftc8inx 10302 10 GP.Hut GP.Hut NNP cord-010092-uftc8inx 10302 11 phenotype phenotype NN cord-010092-uftc8inx 10302 12 . . . cord-010092-uftc8inx 10303 1 Both both DT cord-010092-uftc8inx 10303 2 alleles allele NNS cord-010092-uftc8inx 10303 3 codify codify VBP cord-010092-uftc8inx 10303 4 for for IN cord-010092-uftc8inx 10303 5 the the DT cord-010092-uftc8inx 10303 6 expression expression NN cord-010092-uftc8inx 10303 7 of of IN cord-010092-uftc8inx 10303 8 Mi Mi NNP cord-010092-uftc8inx 10303 9 a a DT cord-010092-uftc8inx 10303 10 antigen antigen NN cord-010092-uftc8inx 10303 11 since since IN cord-010092-uftc8inx 10303 12 it -PRON- PRP cord-010092-uftc8inx 10303 13 is be VBZ cord-010092-uftc8inx 10303 14 expressed express VBN cord-010092-uftc8inx 10303 15 on on IN cord-010092-uftc8inx 10303 16 several several JJ cord-010092-uftc8inx 10303 17 hybrids hybrid NNS cord-010092-uftc8inx 10303 18 between between IN cord-010092-uftc8inx 10303 19 the the DT cord-010092-uftc8inx 10303 20 usual usual JJ cord-010092-uftc8inx 10303 21 forms form NNS cord-010092-uftc8inx 10303 22 of of IN cord-010092-uftc8inx 10303 23 glycophorin glycophorin NNP cord-010092-uftc8inx 10303 24 A A NNP cord-010092-uftc8inx 10303 25 and and CC cord-010092-uftc8inx 10303 26 B. B. NNP cord-010092-uftc8inx 10303 27 Two two CD cord-010092-uftc8inx 10303 28 of of IN cord-010092-uftc8inx 10303 29 these these DT cord-010092-uftc8inx 10303 30 three three CD cord-010092-uftc8inx 10303 31 GP.Hut GP.Hut NNP cord-010092-uftc8inx 10303 32 samples sample NNS cord-010092-uftc8inx 10303 33 are be VBP cord-010092-uftc8inx 10303 34 African african JJ cord-010092-uftc8inx 10303 35 - - HYPH cord-010092-uftc8inx 10303 36 American american JJ cord-010092-uftc8inx 10303 37 donors donor NNS cord-010092-uftc8inx 10303 38 . . . cord-010092-uftc8inx 10304 1 GP.Hut GP.Hut NNP cord-010092-uftc8inx 10304 2 was be VBD cord-010092-uftc8inx 10304 3 reported report VBN cord-010092-uftc8inx 10304 4 in in IN cord-010092-uftc8inx 10304 5 white white JJ cord-010092-uftc8inx 10304 6 people people NNS cord-010092-uftc8inx 10304 7 with with IN cord-010092-uftc8inx 10304 8 a a DT cord-010092-uftc8inx 10304 9 frequency frequency NN cord-010092-uftc8inx 10304 10 about about RB cord-010092-uftc8inx 10304 11 0.06 0.06 CD cord-010092-uftc8inx 10304 12 % % NN cord-010092-uftc8inx 10304 13 and and CC cord-010092-uftc8inx 10304 14 in in IN cord-010092-uftc8inx 10304 15 Thais Thais NNP cord-010092-uftc8inx 10304 16 with with IN cord-010092-uftc8inx 10304 17 0.04 0.04 CD cord-010092-uftc8inx 10304 18 % % NN cord-010092-uftc8inx 10304 19 . . . cord-010092-uftc8inx 10305 1 These these DT cord-010092-uftc8inx 10305 2 three three CD cord-010092-uftc8inx 10305 3 GP.Hut GP.Hut NNP cord-010092-uftc8inx 10305 4 cases case NNS cord-010092-uftc8inx 10305 5 found find VBN cord-010092-uftc8inx 10305 6 by by IN cord-010092-uftc8inx 10305 7 ID ID NNP cord-010092-uftc8inx 10305 8 CORE CORE NNP cord-010092-uftc8inx 10305 9 XT XT NNP cord-010092-uftc8inx 10305 10 in in IN cord-010092-uftc8inx 10305 11 this this DT cord-010092-uftc8inx 10305 12 study study NN cord-010092-uftc8inx 10305 13 point point NN cord-010092-uftc8inx 10305 14 to to IN cord-010092-uftc8inx 10305 15 a a DT cord-010092-uftc8inx 10305 16 higher high JJR cord-010092-uftc8inx 10305 17 frequency frequency NN cord-010092-uftc8inx 10305 18 of of IN cord-010092-uftc8inx 10305 19 this this DT cord-010092-uftc8inx 10305 20 glycophorin glycophorin NN cord-010092-uftc8inx 10305 21 variant variant NN cord-010092-uftc8inx 10305 22 and and CC cord-010092-uftc8inx 10305 23 also also RB cord-010092-uftc8inx 10305 24 to to IN cord-010092-uftc8inx 10305 25 the the DT cord-010092-uftc8inx 10305 26 presence presence NN cord-010092-uftc8inx 10305 27 in in IN cord-010092-uftc8inx 10305 28 African african JJ cord-010092-uftc8inx 10305 29 American american JJ cord-010092-uftc8inx 10305 30 population population NN cord-010092-uftc8inx 10305 31 . . . cord-010092-uftc8inx 10306 1 Summary Summary NNP cord-010092-uftc8inx 10306 2 / / SYM cord-010092-uftc8inx 10306 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 10306 4 : : : cord-010092-uftc8inx 10307 1 ID ID NNP cord-010092-uftc8inx 10307 2 CORE CORE NNP cord-010092-uftc8inx 10307 3 XT XT NNP cord-010092-uftc8inx 10307 4 was be VBD cord-010092-uftc8inx 10307 5 able able JJ cord-010092-uftc8inx 10307 6 to to TO cord-010092-uftc8inx 10307 7 detect detect VB cord-010092-uftc8inx 10307 8 two two CD cord-010092-uftc8inx 10307 9 glycophorin glycophorin NN cord-010092-uftc8inx 10307 10 phenotypes phenotype NNS cord-010092-uftc8inx 10307 11 , , , cord-010092-uftc8inx 10307 12 GP.Mur GP.Mur NNP cord-010092-uftc8inx 10307 13 and and CC cord-010092-uftc8inx 10307 14 GP.Hut GP.Hut NNP cord-010092-uftc8inx 10307 15 , , , cord-010092-uftc8inx 10307 16 which which WDT cord-010092-uftc8inx 10307 17 codify codify VBP cord-010092-uftc8inx 10307 18 for for IN cord-010092-uftc8inx 10307 19 the the DT cord-010092-uftc8inx 10307 20 expression expression NN cord-010092-uftc8inx 10307 21 of of IN cord-010092-uftc8inx 10307 22 Mi Mi NNP cord-010092-uftc8inx 10307 23 a a DT cord-010092-uftc8inx 10307 24 antigen antigen NN cord-010092-uftc8inx 10307 25 . . . cord-010092-uftc8inx 10308 1 Standard standard JJ cord-010092-uftc8inx 10308 2 molecular molecular JJ cord-010092-uftc8inx 10308 3 methods method NNS cord-010092-uftc8inx 10308 4 should should MD cord-010092-uftc8inx 10308 5 be be VB cord-010092-uftc8inx 10308 6 implemented implement VBN cord-010092-uftc8inx 10308 7 in in IN cord-010092-uftc8inx 10308 8 pre pre JJ cord-010092-uftc8inx 10308 9 - - JJ cord-010092-uftc8inx 10308 10 transfusion transfusion JJ cord-010092-uftc8inx 10308 11 testing testing NN cord-010092-uftc8inx 10308 12 and and CC cord-010092-uftc8inx 10308 13 obstetrical obstetrical JJ cord-010092-uftc8inx 10308 14 care care NN cord-010092-uftc8inx 10308 15 routine routine NN cord-010092-uftc8inx 10308 16 to to TO cord-010092-uftc8inx 10308 17 detect detect VB cord-010092-uftc8inx 10308 18 the the DT cord-010092-uftc8inx 10308 19 most most RBS cord-010092-uftc8inx 10308 20 clinically clinically RB cord-010092-uftc8inx 10308 21 relevant relevant JJ cord-010092-uftc8inx 10308 22 glycophorin glycophorin NN cord-010092-uftc8inx 10308 23 variants variant NNS cord-010092-uftc8inx 10308 24 in in IN cord-010092-uftc8inx 10308 25 MNS MNS NNP cord-010092-uftc8inx 10308 26 system system NN cord-010092-uftc8inx 10308 27 . . . cord-010092-uftc8inx 10309 1 Background background NN cord-010092-uftc8inx 10309 2 : : : cord-010092-uftc8inx 10309 3 SERF(+ SERF(+ NNP cord-010092-uftc8inx 10309 4 ) ) -RRB- cord-010092-uftc8inx 10309 5 is be VBZ cord-010092-uftc8inx 10309 6 a a DT cord-010092-uftc8inx 10309 7 high high JJ cord-010092-uftc8inx 10309 8 prevalence prevalence NN cord-010092-uftc8inx 10309 9 antigen antigen NN cord-010092-uftc8inx 10309 10 in in IN cord-010092-uftc8inx 10309 11 the the DT cord-010092-uftc8inx 10309 12 Cromer Cromer NNP cord-010092-uftc8inx 10309 13 blood blood NN cord-010092-uftc8inx 10309 14 group group NN cord-010092-uftc8inx 10309 15 system system NN cord-010092-uftc8inx 10309 16 , , , cord-010092-uftc8inx 10309 17 which which WDT cord-010092-uftc8inx 10309 18 is be VBZ cord-010092-uftc8inx 10309 19 encoded encode VBN cord-010092-uftc8inx 10309 20 by by IN cord-010092-uftc8inx 10309 21 a a DT cord-010092-uftc8inx 10309 22 CROM*12 CROM*12 NNP cord-010092-uftc8inx 10309 23 allele allele NN cord-010092-uftc8inx 10309 24 . . . cord-010092-uftc8inx 10310 1 The the DT cord-010092-uftc8inx 10310 2 lack lack NN cord-010092-uftc8inx 10310 3 of of IN cord-010092-uftc8inx 10310 4 the the DT cord-010092-uftc8inx 10310 5 SERF SERF NNP cord-010092-uftc8inx 10310 6 antigen antigen NN cord-010092-uftc8inx 10310 7 , , , cord-010092-uftc8inx 10310 8 SERF(À serf(à NN cord-010092-uftc8inx 10310 9 ) ) -RRB- cord-010092-uftc8inx 10310 10 on on IN cord-010092-uftc8inx 10310 11 red red JJ cord-010092-uftc8inx 10310 12 cells cell NNS cord-010092-uftc8inx 10310 13 is be VBZ cord-010092-uftc8inx 10310 14 caused cause VBN cord-010092-uftc8inx 10310 15 by by IN cord-010092-uftc8inx 10310 16 a a DT cord-010092-uftc8inx 10310 17 single single JJ cord-010092-uftc8inx 10310 18 nucleotide nucleotide JJ cord-010092-uftc8inx 10310 19 polymorphism polymorphism NN cord-010092-uftc8inx 10310 20 , , , cord-010092-uftc8inx 10310 21 c.647C c.647C NNP cord-010092-uftc8inx 10310 22 > > XX cord-010092-uftc8inx 10311 1 T T NNP cord-010092-uftc8inx 10311 2 in in IN cord-010092-uftc8inx 10311 3 exon exon NN cord-010092-uftc8inx 10311 4 5 5 CD cord-010092-uftc8inx 10311 5 of of IN cord-010092-uftc8inx 10311 6 the the DT cord-010092-uftc8inx 10311 7 Decay decay NN cord-010092-uftc8inx 10311 8 - - HYPH cord-010092-uftc8inx 10311 9 accelerating accelerate VBG cord-010092-uftc8inx 10311 10 factor factor NN cord-010092-uftc8inx 10311 11 , , , cord-010092-uftc8inx 10311 12 DAF DAF NNP cord-010092-uftc8inx 10311 13 gene gene NN cord-010092-uftc8inx 10311 14 . . . cord-010092-uftc8inx 10312 1 Alloanti Alloanti NNP cord-010092-uftc8inx 10312 2 - - HYPH cord-010092-uftc8inx 10312 3 SERF SERF NNP cord-010092-uftc8inx 10312 4 has have VBZ cord-010092-uftc8inx 10312 5 been be VBN cord-010092-uftc8inx 10312 6 found find VBN cord-010092-uftc8inx 10312 7 in in IN cord-010092-uftc8inx 10312 8 Thai thai JJ cord-010092-uftc8inx 10312 9 pregnant pregnant JJ cord-010092-uftc8inx 10312 10 woman woman NN cord-010092-uftc8inx 10312 11 with with IN cord-010092-uftc8inx 10312 12 SERF(À serf(à NN cord-010092-uftc8inx 10312 13 ) ) -RRB- cord-010092-uftc8inx 10312 14 and and CC cord-010092-uftc8inx 10312 15 a a DT cord-010092-uftc8inx 10312 16 SERF(À serf(à NN cord-010092-uftc8inx 10313 1 ) ) -RRB- cord-010092-uftc8inx 10313 2 individual individual NN cord-010092-uftc8inx 10313 3 was be VBD cord-010092-uftc8inx 10313 4 found find VBN cord-010092-uftc8inx 10313 5 among among IN cord-010092-uftc8inx 10313 6 Thai Thai NNP cord-010092-uftc8inx 10313 7 blood blood NN cord-010092-uftc8inx 10313 8 donors donor NNS cord-010092-uftc8inx 10313 9 . . . cord-010092-uftc8inx 10314 1 Anti anti JJ cord-010092-uftc8inx 10314 2 - - NNP cord-010092-uftc8inx 10314 3 SERF SERF NNP cord-010092-uftc8inx 10314 4 is be VBZ cord-010092-uftc8inx 10314 5 not not RB cord-010092-uftc8inx 10314 6 a a DT cord-010092-uftc8inx 10314 7 marketed market VBN cord-010092-uftc8inx 10314 8 product product NN cord-010092-uftc8inx 10314 9 ; ; : cord-010092-uftc8inx 10314 10 hence hence RB cord-010092-uftc8inx 10314 11 , , , cord-010092-uftc8inx 10314 12 a a DT cord-010092-uftc8inx 10314 13 molecular molecular JJ cord-010092-uftc8inx 10314 14 technique technique NN cord-010092-uftc8inx 10314 15 has have VBZ cord-010092-uftc8inx 10314 16 to to TO cord-010092-uftc8inx 10314 17 be be VB cord-010092-uftc8inx 10314 18 implemented implement VBN cord-010092-uftc8inx 10314 19 to to TO cord-010092-uftc8inx 10314 20 genotype genotype VB cord-010092-uftc8inx 10314 21 for for IN cord-010092-uftc8inx 10314 22 the the DT cord-010092-uftc8inx 10314 23 CROM*12 CROM*12 NNP cord-010092-uftc8inx 10314 24 allele allele NN cord-010092-uftc8inx 10314 25 among among IN cord-010092-uftc8inx 10314 26 blood blood NN cord-010092-uftc8inx 10314 27 donors donor NNS cord-010092-uftc8inx 10314 28 . . . cord-010092-uftc8inx 10315 1 Aims aim VBZ cord-010092-uftc8inx 10315 2 : : : cord-010092-uftc8inx 10316 1 This this DT cord-010092-uftc8inx 10316 2 study study NN cord-010092-uftc8inx 10316 3 aimed aim VBD cord-010092-uftc8inx 10316 4 to to TO cord-010092-uftc8inx 10316 5 identify identify VB cord-010092-uftc8inx 10316 6 the the DT cord-010092-uftc8inx 10316 7 CROM*12 CROM*12 NNP cord-010092-uftc8inx 10316 8 allele allele NN cord-010092-uftc8inx 10316 9 among among IN cord-010092-uftc8inx 10316 10 Thai Thai NNP cord-010092-uftc8inx 10316 11 blood blood NN cord-010092-uftc8inx 10316 12 donors donor NNS cord-010092-uftc8inx 10316 13 leading lead VBG cord-010092-uftc8inx 10316 14 to to IN cord-010092-uftc8inx 10316 15 predicted predict VBN cord-010092-uftc8inx 10316 16 SERF(+ SERF(+ NNP cord-010092-uftc8inx 10316 17 ) ) -RRB- cord-010092-uftc8inx 10316 18 and and CC cord-010092-uftc8inx 10316 19 SERF(À serf(à LS cord-010092-uftc8inx 10316 20 ) ) -RRB- cord-010092-uftc8inx 10316 21 phenotypes phenotype NNS cord-010092-uftc8inx 10316 22 . . . cord-010092-uftc8inx 10317 1 Methods method NNS cord-010092-uftc8inx 10317 2 : : : cord-010092-uftc8inx 10317 3 DNA dna NN cord-010092-uftc8inx 10317 4 samples sample NNS cord-010092-uftc8inx 10317 5 obtained obtain VBN cord-010092-uftc8inx 10317 6 from from IN cord-010092-uftc8inx 10317 7 1,512 1,512 CD cord-010092-uftc8inx 10317 8 central central JJ cord-010092-uftc8inx 10317 9 Thai Thai NNP cord-010092-uftc8inx 10317 10 blood blood NN cord-010092-uftc8inx 10317 11 donors donor NNS cord-010092-uftc8inx 10317 12 were be VBD cord-010092-uftc8inx 10317 13 genotyped genotype VBN cord-010092-uftc8inx 10317 14 for for IN cord-010092-uftc8inx 10317 15 SERF SERF NNP cord-010092-uftc8inx 10317 16 allele allele NN cord-010092-uftc8inx 10317 17 detection detection NN cord-010092-uftc8inx 10317 18 using use VBG cord-010092-uftc8inx 10317 19 in in IN cord-010092-uftc8inx 10317 20 - - HYPH cord-010092-uftc8inx 10317 21 house house NN cord-010092-uftc8inx 10317 22 PCR PCR NNP cord-010092-uftc8inx 10317 23 with with IN cord-010092-uftc8inx 10317 24 sequence sequence NN cord-010092-uftc8inx 10317 25 - - HYPH cord-010092-uftc8inx 10317 26 specific specific JJ cord-010092-uftc8inx 10317 27 primer primer NN cord-010092-uftc8inx 10317 28 ( ( -LRB- cord-010092-uftc8inx 10317 29 PCR PCR NNP cord-010092-uftc8inx 10317 30 - - HYPH cord-010092-uftc8inx 10317 31 SSP SSP NNP cord-010092-uftc8inx 10317 32 ) ) -RRB- cord-010092-uftc8inx 10317 33 and and CC cord-010092-uftc8inx 10317 34 confirmed confirm VBN cord-010092-uftc8inx 10317 35 by by IN cord-010092-uftc8inx 10317 36 DNA dna NN cord-010092-uftc8inx 10317 37 sequencing sequencing NN cord-010092-uftc8inx 10317 38 . . . cord-010092-uftc8inx 10318 1 Results result NNS cord-010092-uftc8inx 10318 2 : : : cord-010092-uftc8inx 10319 1 The the DT cord-010092-uftc8inx 10319 2 allele allele NN cord-010092-uftc8inx 10319 3 frequencies frequency NNS cord-010092-uftc8inx 10319 4 of of IN cord-010092-uftc8inx 10319 5 CROM*12(+ CROM*12(+ NNP cord-010092-uftc8inx 10319 6 ) ) -RRB- cord-010092-uftc8inx 10319 7 and and CC cord-010092-uftc8inx 10319 8 CROM*12(À CROM*12(À NNP cord-010092-uftc8inx 10319 9 ) ) -RRB- cord-010092-uftc8inx 10319 10 among among IN cord-010092-uftc8inx 10319 11 1,512 1,512 CD cord-010092-uftc8inx 10319 12 central central JJ cord-010092-uftc8inx 10319 13 Thais Thais NNPS cord-010092-uftc8inx 10319 14 were be VBD cord-010092-uftc8inx 10319 15 0.992 0.992 CD cord-010092-uftc8inx 10319 16 ( ( -LRB- cord-010092-uftc8inx 10319 17 3,001/3,024 3,001/3,024 CD cord-010092-uftc8inx 10319 18 ) ) -RRB- cord-010092-uftc8inx 10319 19 and and CC cord-010092-uftc8inx 10319 20 0.008 0.008 CD cord-010092-uftc8inx 10319 21 ( ( -LRB- cord-010092-uftc8inx 10319 22 23/3,024 23/3,024 NNP cord-010092-uftc8inx 10319 23 ) ) -RRB- cord-010092-uftc8inx 10319 24 , , , cord-010092-uftc8inx 10319 25 respectively respectively RB cord-010092-uftc8inx 10319 26 . . . cord-010092-uftc8inx 10320 1 The the DT cord-010092-uftc8inx 10320 2 homozygous homozygous NN cord-010092-uftc8inx 10320 3 of of IN cord-010092-uftc8inx 10320 4 CROM*12(À CROM*12(À NNP cord-010092-uftc8inx 10320 5 / / SYM cord-010092-uftc8inx 10320 6 À à NN cord-010092-uftc8inx 10320 7 ) ) -RRB- cord-010092-uftc8inx 10320 8 alleles allele NNS cord-010092-uftc8inx 10320 9 was be VBD cord-010092-uftc8inx 10320 10 not not RB cord-010092-uftc8inx 10320 11 found find VBN cord-010092-uftc8inx 10320 12 in in IN cord-010092-uftc8inx 10320 13 this this DT cord-010092-uftc8inx 10320 14 study study NN cord-010092-uftc8inx 10320 15 . . . cord-010092-uftc8inx 10321 1 Additionally additionally RB cord-010092-uftc8inx 10321 2 , , , cord-010092-uftc8inx 10321 3 the the DT cord-010092-uftc8inx 10321 4 PCR PCR NNP cord-010092-uftc8inx 10321 5 - - HYPH cord-010092-uftc8inx 10321 6 SSP SSP NNP cord-010092-uftc8inx 10321 7 technique technique NN cord-010092-uftc8inx 10321 8 was be VBD cord-010092-uftc8inx 10321 9 validated validate VBN cord-010092-uftc8inx 10321 10 by by IN cord-010092-uftc8inx 10321 11 DNA dna NN cord-010092-uftc8inx 10321 12 sequencing sequencing NN cord-010092-uftc8inx 10321 13 using use VBG cord-010092-uftc8inx 10321 14 randomly randomly RB cord-010092-uftc8inx 10321 15 chosen choose VBN cord-010092-uftc8inx 10321 16 100 100 CD cord-010092-uftc8inx 10321 17 samples sample NNS cord-010092-uftc8inx 10321 18 together together RB cord-010092-uftc8inx 10321 19 with with IN cord-010092-uftc8inx 10321 20 23 23 CD cord-010092-uftc8inx 10321 21 heterozygous heterozygous JJ cord-010092-uftc8inx 10321 22 CROM*12(+/À CROM*12(+/À NNP cord-010092-uftc8inx 10321 23 ) ) -RRB- cord-010092-uftc8inx 10321 24 samples sample NNS cord-010092-uftc8inx 10321 25 and and CC cord-010092-uftc8inx 10321 26 the the DT cord-010092-uftc8inx 10321 27 results result NNS cord-010092-uftc8inx 10321 28 were be VBD cord-010092-uftc8inx 10321 29 in in IN cord-010092-uftc8inx 10321 30 agreement agreement NN cord-010092-uftc8inx 10321 31 . . . cord-010092-uftc8inx 10322 1 Summary Summary NNP cord-010092-uftc8inx 10322 2 / / SYM cord-010092-uftc8inx 10322 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 10322 4 : : : cord-010092-uftc8inx 10323 1 Our -PRON- PRP$ cord-010092-uftc8inx 10323 2 results result NNS cord-010092-uftc8inx 10323 3 confirm confirm VBP cord-010092-uftc8inx 10323 4 a a DT cord-010092-uftc8inx 10323 5 high high JJ cord-010092-uftc8inx 10323 6 frequency frequency NN cord-010092-uftc8inx 10323 7 of of IN cord-010092-uftc8inx 10323 8 the the DT cord-010092-uftc8inx 10323 9 CROM*12(+ CROM*12(+ NNP cord-010092-uftc8inx 10323 10 ) ) -RRB- cord-010092-uftc8inx 10324 1 allele allele NN cord-010092-uftc8inx 10324 2 in in IN cord-010092-uftc8inx 10324 3 the the DT cord-010092-uftc8inx 10324 4 Thai thai JJ cord-010092-uftc8inx 10324 5 population population NN cord-010092-uftc8inx 10324 6 and and CC cord-010092-uftc8inx 10324 7 their -PRON- PRP$ cord-010092-uftc8inx 10324 8 frequencies frequency NNS cord-010092-uftc8inx 10324 9 were be VBD cord-010092-uftc8inx 10324 10 similar similar JJ cord-010092-uftc8inx 10324 11 to to IN cord-010092-uftc8inx 10324 12 those those DT cord-010092-uftc8inx 10324 13 formerly formerly RB cord-010092-uftc8inx 10324 14 reported report VBN cord-010092-uftc8inx 10324 15 among among IN cord-010092-uftc8inx 10324 16 Thai Thai NNP cord-010092-uftc8inx 10324 17 blood blood NN cord-010092-uftc8inx 10324 18 donors donor NNS cord-010092-uftc8inx 10324 19 . . . cord-010092-uftc8inx 10325 1 This this DT cord-010092-uftc8inx 10325 2 study study NN cord-010092-uftc8inx 10325 3 would would MD cord-010092-uftc8inx 10325 4 be be VB cord-010092-uftc8inx 10325 5 beneficial beneficial JJ cord-010092-uftc8inx 10325 6 to to TO cord-010092-uftc8inx 10325 7 predict predict VB cord-010092-uftc8inx 10325 8 the the DT cord-010092-uftc8inx 10325 9 SERF serf NN cord-010092-uftc8inx 10325 10 antigen antigen NN cord-010092-uftc8inx 10325 11 from from IN cord-010092-uftc8inx 10325 12 genotyping genotyping NN cord-010092-uftc8inx 10325 13 results result NNS cord-010092-uftc8inx 10325 14 due due JJ cord-010092-uftc8inx 10325 15 to to IN cord-010092-uftc8inx 10325 16 unavailability unavailability NN cord-010092-uftc8inx 10325 17 of of IN cord-010092-uftc8inx 10325 18 commercial commercial JJ cord-010092-uftc8inx 10325 19 antiserum antiserum NN cord-010092-uftc8inx 10325 20 . . . cord-010092-uftc8inx 10326 1 Background background NN cord-010092-uftc8inx 10326 2 : : : cord-010092-uftc8inx 10327 1 There there EX cord-010092-uftc8inx 10327 2 is be VBZ cord-010092-uftc8inx 10327 3 increasing increase VBG cord-010092-uftc8inx 10327 4 interest interest NN cord-010092-uftc8inx 10327 5 in in IN cord-010092-uftc8inx 10327 6 the the DT cord-010092-uftc8inx 10327 7 use use NN cord-010092-uftc8inx 10327 8 of of IN cord-010092-uftc8inx 10327 9 molecular molecular JJ cord-010092-uftc8inx 10327 10 methods method NNS cord-010092-uftc8inx 10327 11 for for IN cord-010092-uftc8inx 10327 12 predicting predict VBG cord-010092-uftc8inx 10327 13 ABO ABO NNP cord-010092-uftc8inx 10327 14 grouping grouping NN cord-010092-uftc8inx 10327 15 . . . cord-010092-uftc8inx 10328 1 Though though IN cord-010092-uftc8inx 10328 2 NextGen NextGen NNP cord-010092-uftc8inx 10328 3 and and CC cord-010092-uftc8inx 10328 4 Sanger Sanger NNP cord-010092-uftc8inx 10328 5 sequencing sequencing NN cord-010092-uftc8inx 10328 6 have have VBP cord-010092-uftc8inx 10328 7 both both DT cord-010092-uftc8inx 10328 8 been be VBN cord-010092-uftc8inx 10328 9 used use VBN cord-010092-uftc8inx 10328 10 to to TO cord-010092-uftc8inx 10328 11 predict predict VB cord-010092-uftc8inx 10328 12 ABO ABO NNP cord-010092-uftc8inx 10328 13 type type NN cord-010092-uftc8inx 10328 14 , , , cord-010092-uftc8inx 10328 15 predicting predict VBG cord-010092-uftc8inx 10328 16 ABO ABO NNP cord-010092-uftc8inx 10328 17 type type NN cord-010092-uftc8inx 10328 18 from from IN cord-010092-uftc8inx 10328 19 buccal buccal JJ cord-010092-uftc8inx 10328 20 swab swab NN cord-010092-uftc8inx 10328 21 - - HYPH cord-010092-uftc8inx 10328 22 derived derive VBN cord-010092-uftc8inx 10328 23 DNA dna NN cord-010092-uftc8inx 10328 24 and and CC cord-010092-uftc8inx 10328 25 from from IN cord-010092-uftc8inx 10328 26 deceased deceased JJ cord-010092-uftc8inx 10328 27 donors donor NNS cord-010092-uftc8inx 10328 28 benefits benefit NNS cord-010092-uftc8inx 10328 29 from from IN cord-010092-uftc8inx 10328 30 a a DT cord-010092-uftc8inx 10328 31 quick quick JJ cord-010092-uftc8inx 10328 32 and and CC cord-010092-uftc8inx 10328 33 reliable reliable JJ cord-010092-uftc8inx 10328 34 method method NN cord-010092-uftc8inx 10328 35 . . . cord-010092-uftc8inx 10329 1 Besides besides IN cord-010092-uftc8inx 10329 2 a a DT cord-010092-uftc8inx 10329 3 PCR PCR NNP cord-010092-uftc8inx 10329 4 - - HYPH cord-010092-uftc8inx 10329 5 RFLP RFLP NNP cord-010092-uftc8inx 10329 6 that that WDT cord-010092-uftc8inx 10329 7 has have VBZ cord-010092-uftc8inx 10329 8 been be VBN cord-010092-uftc8inx 10329 9 used use VBN cord-010092-uftc8inx 10329 10 by by IN cord-010092-uftc8inx 10329 11 many many JJ cord-010092-uftc8inx 10329 12 labs lab NNS cord-010092-uftc8inx 10329 13 for for IN cord-010092-uftc8inx 10329 14 more more JJR cord-010092-uftc8inx 10329 15 than than IN cord-010092-uftc8inx 10329 16 25 25 CD cord-010092-uftc8inx 10329 17 years year NNS cord-010092-uftc8inx 10329 18 , , , cord-010092-uftc8inx 10329 19 there there EX cord-010092-uftc8inx 10329 20 is be VBZ cord-010092-uftc8inx 10329 21 a a DT cord-010092-uftc8inx 10329 22 commercially commercially RB cord-010092-uftc8inx 10329 23 - - HYPH cord-010092-uftc8inx 10329 24 available available JJ cord-010092-uftc8inx 10329 25 research research NN cord-010092-uftc8inx 10329 26 use use NN cord-010092-uftc8inx 10329 27 only only RB cord-010092-uftc8inx 10329 28 ( ( -LRB- cord-010092-uftc8inx 10329 29 RUO RUO NNP cord-010092-uftc8inx 10329 30 ) ) -RRB- cord-010092-uftc8inx 10329 31 kit kit NN cord-010092-uftc8inx 10329 32 , , , cord-010092-uftc8inx 10329 33 and and CC cord-010092-uftc8inx 10329 34 both both DT cord-010092-uftc8inx 10329 35 interrogate interrogate VBP cord-010092-uftc8inx 10329 36 nucleotides nucleotide NNS cord-010092-uftc8inx 10329 37 associated associate VBN cord-010092-uftc8inx 10329 38 with with IN cord-010092-uftc8inx 10329 39 O1 O1 NNP cord-010092-uftc8inx 10329 40 , , , cord-010092-uftc8inx 10329 41 O2 O2 NNP cord-010092-uftc8inx 10329 42 , , , cord-010092-uftc8inx 10329 43 A2 A2 NNP cord-010092-uftc8inx 10329 44 and and CC cord-010092-uftc8inx 10329 45 B B NNP cord-010092-uftc8inx 10329 46 with with IN cord-010092-uftc8inx 10329 47 A a DT cord-010092-uftc8inx 10329 48 representing represent VBG cord-010092-uftc8inx 10329 49 the the DT cord-010092-uftc8inx 10329 50 ancestral ancestral JJ cord-010092-uftc8inx 10329 51 allele allele NN cord-010092-uftc8inx 10329 52 . . . cord-010092-uftc8inx 10330 1 Aims aim VBZ cord-010092-uftc8inx 10330 2 : : : cord-010092-uftc8inx 10331 1 The the DT cord-010092-uftc8inx 10331 2 aim aim NN cord-010092-uftc8inx 10331 3 of of IN cord-010092-uftc8inx 10331 4 this this DT cord-010092-uftc8inx 10331 5 report report NN cord-010092-uftc8inx 10331 6 is be VBZ cord-010092-uftc8inx 10331 7 to to TO cord-010092-uftc8inx 10331 8 compare compare VB cord-010092-uftc8inx 10331 9 two two CD cord-010092-uftc8inx 10331 10 low low JJ cord-010092-uftc8inx 10331 11 - - HYPH cord-010092-uftc8inx 10331 12 resolution resolution NN cord-010092-uftc8inx 10331 13 polymerase polymerase NN cord-010092-uftc8inx 10331 14 chain chain NN cord-010092-uftc8inx 10331 15 reaction reaction NN cord-010092-uftc8inx 10331 16 ( ( -LRB- cord-010092-uftc8inx 10331 17 PCR)-based pcr)-base VBN cord-010092-uftc8inx 10331 18 methods method NNS cord-010092-uftc8inx 10331 19 , , , cord-010092-uftc8inx 10331 20 for for IN cord-010092-uftc8inx 10331 21 investigation investigation NN cord-010092-uftc8inx 10331 22 of of IN cord-010092-uftc8inx 10331 23 samples sample NNS cord-010092-uftc8inx 10331 24 submitted submit VBN cord-010092-uftc8inx 10331 25 to to IN cord-010092-uftc8inx 10331 26 a a DT cord-010092-uftc8inx 10331 27 reference reference NN cord-010092-uftc8inx 10331 28 molecular molecular JJ cord-010092-uftc8inx 10331 29 immunohematology immunohematology NN cord-010092-uftc8inx 10331 30 laboratory laboratory NN cord-010092-uftc8inx 10331 31 for for IN cord-010092-uftc8inx 10331 32 ABO ABO NNP cord-010092-uftc8inx 10331 33 typing type VBG cord-010092-uftc8inx 10331 34 discrepancies discrepancy NNS cord-010092-uftc8inx 10331 35 . . . cord-010092-uftc8inx 10332 1 Fifty fifty CD cord-010092-uftc8inx 10332 2 - - HYPH cord-010092-uftc8inx 10332 3 six six CD cord-010092-uftc8inx 10332 4 peripheral peripheral JJ cord-010092-uftc8inx 10332 5 blood blood NN cord-010092-uftc8inx 10332 6 samples sample NNS cord-010092-uftc8inx 10332 7 were be VBD cord-010092-uftc8inx 10332 8 tested test VBN cord-010092-uftc8inx 10332 9 , , , cord-010092-uftc8inx 10332 10 31 31 CD cord-010092-uftc8inx 10332 11 from from IN cord-010092-uftc8inx 10332 12 patients patient NNS cord-010092-uftc8inx 10332 13 and and CC cord-010092-uftc8inx 10332 14 25 25 CD cord-010092-uftc8inx 10332 15 from from IN cord-010092-uftc8inx 10332 16 blood blood NN cord-010092-uftc8inx 10332 17 donors donor NNS cord-010092-uftc8inx 10332 18 . . . cord-010092-uftc8inx 10333 1 Methods method NNS cord-010092-uftc8inx 10333 2 : : : cord-010092-uftc8inx 10334 1 Genomic genomic JJ cord-010092-uftc8inx 10334 2 DNA dna NN cord-010092-uftc8inx 10334 3 was be VBD cord-010092-uftc8inx 10334 4 isolated isolate VBN cord-010092-uftc8inx 10334 5 from from IN cord-010092-uftc8inx 10334 6 peripheral peripheral JJ cord-010092-uftc8inx 10334 7 blood blood NN cord-010092-uftc8inx 10334 8 mononuclear mononuclear NN cord-010092-uftc8inx 10334 9 cells cell NNS cord-010092-uftc8inx 10334 10 . . . cord-010092-uftc8inx 10335 1 Background background NN cord-010092-uftc8inx 10335 2 : : : cord-010092-uftc8inx 10336 1 DEL DEL NNP cord-010092-uftc8inx 10336 2 is be VBZ cord-010092-uftc8inx 10336 3 the the DT cord-010092-uftc8inx 10336 4 weakest weak JJS cord-010092-uftc8inx 10336 5 known know VBN cord-010092-uftc8inx 10336 6 D d NN cord-010092-uftc8inx 10336 7 positive positive JJ cord-010092-uftc8inx 10336 8 phenotype phenotype NN cord-010092-uftc8inx 10336 9 in in IN cord-010092-uftc8inx 10336 10 the the DT cord-010092-uftc8inx 10336 11 Rh Rh NNP cord-010092-uftc8inx 10336 12 blood blood NN cord-010092-uftc8inx 10336 13 group group NN cord-010092-uftc8inx 10336 14 system system NN cord-010092-uftc8inx 10336 15 and and CC cord-010092-uftc8inx 10336 16 detectable detectable JJ cord-010092-uftc8inx 10336 17 only only RB cord-010092-uftc8inx 10336 18 by by IN cord-010092-uftc8inx 10336 19 adsorption adsorption NN cord-010092-uftc8inx 10336 20 and and CC cord-010092-uftc8inx 10336 21 elution elution NN cord-010092-uftc8inx 10336 22 tests test NNS cord-010092-uftc8inx 10336 23 . . . cord-010092-uftc8inx 10337 1 The the DT cord-010092-uftc8inx 10337 2 RHD1227 RHD1227 NNP cord-010092-uftc8inx 10337 3 G g NN cord-010092-uftc8inx 10338 1 > > XX cord-010092-uftc8inx 10339 1 A a DT cord-010092-uftc8inx 10339 2 change change NN cord-010092-uftc8inx 10339 3 is be VBZ cord-010092-uftc8inx 10339 4 an an DT cord-010092-uftc8inx 10339 5 important important JJ cord-010092-uftc8inx 10339 6 marker marker NN cord-010092-uftc8inx 10339 7 for for IN cord-010092-uftc8inx 10339 8 DEL DEL NNP cord-010092-uftc8inx 10339 9 phenotype phenotype NN cord-010092-uftc8inx 10339 10 in in IN cord-010092-uftc8inx 10339 11 East East NNP cord-010092-uftc8inx 10339 12 Asians Asians NNPS cord-010092-uftc8inx 10339 13 . . . cord-010092-uftc8inx 10340 1 A a DT cord-010092-uftc8inx 10340 2 rapid rapid JJ cord-010092-uftc8inx 10340 3 and and CC cord-010092-uftc8inx 10340 4 efficient efficient JJ cord-010092-uftc8inx 10340 5 PCR pcr NN cord-010092-uftc8inx 10340 6 method method NN cord-010092-uftc8inx 10340 7 for for IN cord-010092-uftc8inx 10340 8 RHD RHD NNP cord-010092-uftc8inx 10340 9 gene gene NN cord-010092-uftc8inx 10340 10 1227 1227 CD cord-010092-uftc8inx 10340 11 G g NN cord-010092-uftc8inx 10341 1 > > XX cord-010092-uftc8inx 10342 1 A a DT cord-010092-uftc8inx 10342 2 genotyping genotyping NN cord-010092-uftc8inx 10342 3 is be VBZ cord-010092-uftc8inx 10342 4 useful useful JJ cord-010092-uftc8inx 10342 5 in in IN cord-010092-uftc8inx 10342 6 East east JJ cord-010092-uftc8inx 10342 7 Asian asian JJ cord-010092-uftc8inx 10342 8 countries country NNS cord-010092-uftc8inx 10342 9 . . . cord-010092-uftc8inx 10343 1 Aims aim VBZ cord-010092-uftc8inx 10343 2 : : : cord-010092-uftc8inx 10344 1 The the DT cord-010092-uftc8inx 10344 2 aim aim NN cord-010092-uftc8inx 10344 3 of of IN cord-010092-uftc8inx 10344 4 this this DT cord-010092-uftc8inx 10344 5 study study NN cord-010092-uftc8inx 10344 6 was be VBD cord-010092-uftc8inx 10344 7 to to TO cord-010092-uftc8inx 10344 8 develop develop VB cord-010092-uftc8inx 10344 9 a a DT cord-010092-uftc8inx 10344 10 method method NN cord-010092-uftc8inx 10344 11 for for IN cord-010092-uftc8inx 10344 12 RHD RHD NNP cord-010092-uftc8inx 10344 13 1227 1227 CD cord-010092-uftc8inx 10344 14 G g NN cord-010092-uftc8inx 10345 1 > > XX cord-010092-uftc8inx 10346 1 A a DT cord-010092-uftc8inx 10346 2 genotyping genotyping NN cord-010092-uftc8inx 10346 3 by by IN cord-010092-uftc8inx 10346 4 using use VBG cord-010092-uftc8inx 10346 5 single single JJ cord-010092-uftc8inx 10346 6 - - HYPH cord-010092-uftc8inx 10346 7 tube tube NN cord-010092-uftc8inx 10346 8 PCR pcr NN cord-010092-uftc8inx 10346 9 with with IN cord-010092-uftc8inx 10346 10 melting melt VBG cord-010092-uftc8inx 10346 11 temperature(T temperature(T NNP cord-010092-uftc8inx 10346 12 m m CD cord-010092-uftc8inx 10346 13 ) ) -RRB- cord-010092-uftc8inx 10346 14 -shift -shift HYPH cord-010092-uftc8inx 10346 15 primers primer NNS cord-010092-uftc8inx 10346 16 . . . cord-010092-uftc8inx 10347 1 Methods method NNS cord-010092-uftc8inx 10347 2 : : : cord-010092-uftc8inx 10348 1 Two two CD cord-010092-uftc8inx 10348 2 allele allele NN cord-010092-uftc8inx 10348 3 - - HYPH cord-010092-uftc8inx 10348 4 specific specific JJ cord-010092-uftc8inx 10348 5 primer primer NN cord-010092-uftc8inx 10348 6 for for IN cord-010092-uftc8inx 10348 7 RHD RHD NNP cord-010092-uftc8inx 10348 8 1227 1227 CD cord-010092-uftc8inx 10348 9 G g NN cord-010092-uftc8inx 10349 1 > > XX cord-010092-uftc8inx 10350 1 A a NN cord-010092-uftc8inx 10350 2 and and CC cord-010092-uftc8inx 10350 3 a a DT cord-010092-uftc8inx 10350 4 common common JJ cord-010092-uftc8inx 10350 5 primer primer NN cord-010092-uftc8inx 10350 6 were be VBD cord-010092-uftc8inx 10350 7 designed design VBN cord-010092-uftc8inx 10350 8 and and CC cord-010092-uftc8inx 10350 9 synthesized synthesize VBN cord-010092-uftc8inx 10350 10 . . . cord-010092-uftc8inx 10351 1 Two two CD cord-010092-uftc8inx 10351 2 GC gc NN cord-010092-uftc8inx 10351 3 - - HYPH cord-010092-uftc8inx 10351 4 rich rich JJ cord-010092-uftc8inx 10351 5 tails tail NNS cord-010092-uftc8inx 10351 6 of of IN cord-010092-uftc8inx 10351 7 different different JJ cord-010092-uftc8inx 10351 8 lengths length NNS cord-010092-uftc8inx 10351 9 were be VBD cord-010092-uftc8inx 10351 10 attached attach VBN cord-010092-uftc8inx 10351 11 to to IN cord-010092-uftc8inx 10351 12 5 5 CD cord-010092-uftc8inx 10351 13 0 0 CD cord-010092-uftc8inx 10351 14 ends end NNS cord-010092-uftc8inx 10351 15 of of IN cord-010092-uftc8inx 10351 16 the the DT cord-010092-uftc8inx 10351 17 allele allele NN cord-010092-uftc8inx 10351 18 - - HYPH cord-010092-uftc8inx 10351 19 specific specific JJ cord-010092-uftc8inx 10351 20 PCR PCR NNP cord-010092-uftc8inx 10351 21 primers primer NNS cord-010092-uftc8inx 10351 22 . . . cord-010092-uftc8inx 10352 1 Single single JJ cord-010092-uftc8inx 10352 2 - - HYPH cord-010092-uftc8inx 10352 3 tube tube NN cord-010092-uftc8inx 10352 4 PCR PCR NNP cord-010092-uftc8inx 10352 5 with with IN cord-010092-uftc8inx 10352 6 T T NNP cord-010092-uftc8inx 10352 7 m m NNP cord-010092-uftc8inx 10352 8 -shift -shift NN cord-010092-uftc8inx 10352 9 primers primer NNS cord-010092-uftc8inx 10352 10 was be VBD cord-010092-uftc8inx 10352 11 carried carry VBN cord-010092-uftc8inx 10352 12 out out RP cord-010092-uftc8inx 10352 13 with with IN cord-010092-uftc8inx 10352 14 the the DT cord-010092-uftc8inx 10352 15 three three CD cord-010092-uftc8inx 10352 16 primers primer NNS cord-010092-uftc8inx 10352 17 . . . cord-010092-uftc8inx 10353 1 After after IN cord-010092-uftc8inx 10353 2 PCR PCR NNP cord-010092-uftc8inx 10353 3 , , , cord-010092-uftc8inx 10353 4 melting melt VBG cord-010092-uftc8inx 10353 5 curve curve NN cord-010092-uftc8inx 10353 6 analysis analysis NN cord-010092-uftc8inx 10353 7 was be VBD cord-010092-uftc8inx 10353 8 performed perform VBN cord-010092-uftc8inx 10353 9 . . . cord-010092-uftc8inx 10354 1 RHD RHD NNP cord-010092-uftc8inx 10354 2 1227 1227 CD cord-010092-uftc8inx 10354 3 G g NN cord-010092-uftc8inx 10355 1 > > XX cord-010092-uftc8inx 10356 1 A a DT cord-010092-uftc8inx 10356 2 could could MD cord-010092-uftc8inx 10356 3 be be VB cord-010092-uftc8inx 10356 4 genotyped genotype VBN cord-010092-uftc8inx 10356 5 by by IN cord-010092-uftc8inx 10356 6 differences difference NNS cord-010092-uftc8inx 10356 7 of of IN cord-010092-uftc8inx 10356 8 the the DT cord-010092-uftc8inx 10356 9 T T NNP cord-010092-uftc8inx 10356 10 m m NNP cord-010092-uftc8inx 10356 11 s s NNP cord-010092-uftc8inx 10356 12 of of IN cord-010092-uftc8inx 10356 13 the the DT cord-010092-uftc8inx 10356 14 PCR PCR NNP cord-010092-uftc8inx 10356 15 products product NNS cord-010092-uftc8inx 10356 16 . . . cord-010092-uftc8inx 10357 1 All all DT cord-010092-uftc8inx 10357 2 of of IN cord-010092-uftc8inx 10357 3 genotyping genotyping NN cord-010092-uftc8inx 10357 4 results result NNS cord-010092-uftc8inx 10357 5 were be VBD cord-010092-uftc8inx 10357 6 compared compare VBN cord-010092-uftc8inx 10357 7 with with IN cord-010092-uftc8inx 10357 8 those those DT cord-010092-uftc8inx 10357 9 obtained obtain VBN cord-010092-uftc8inx 10357 10 from from IN cord-010092-uftc8inx 10357 11 conventional conventional JJ cord-010092-uftc8inx 10357 12 PCR PCR NNP cord-010092-uftc8inx 10357 13 - - HYPH cord-010092-uftc8inx 10357 14 SSP SSP NNP cord-010092-uftc8inx 10357 15 . . . cord-010092-uftc8inx 10358 1 For for IN cord-010092-uftc8inx 10358 2 the the DT cord-010092-uftc8inx 10358 3 discordant discordant JJ cord-010092-uftc8inx 10358 4 results result NNS cord-010092-uftc8inx 10358 5 , , , cord-010092-uftc8inx 10358 6 RhD rhd NN cord-010092-uftc8inx 10358 7 exon exon NNP cord-010092-uftc8inx 10358 8 9 9 CD cord-010092-uftc8inx 10358 9 sequencing sequencing NN cord-010092-uftc8inx 10358 10 was be VBD cord-010092-uftc8inx 10358 11 performed perform VBN cord-010092-uftc8inx 10358 12 to to TO cord-010092-uftc8inx 10358 13 determine determine VB cord-010092-uftc8inx 10358 14 RHD RHD NNP cord-010092-uftc8inx 10358 15 1227 1227 CD cord-010092-uftc8inx 10358 16 G g NN cord-010092-uftc8inx 10359 1 > > XX cord-010092-uftc8inx 10360 1 A a DT cord-010092-uftc8inx 10360 2 genotype genotype NN cord-010092-uftc8inx 10360 3 . . . cord-010092-uftc8inx 10361 1 Results result NNS cord-010092-uftc8inx 10361 2 : : : cord-010092-uftc8inx 10362 1 A a DT cord-010092-uftc8inx 10362 2 total total NN cord-010092-uftc8inx 10362 3 of of IN cord-010092-uftc8inx 10362 4 84 84 CD cord-010092-uftc8inx 10362 5 samples sample NNS cord-010092-uftc8inx 10362 6 were be VBD cord-010092-uftc8inx 10362 7 genotyped genotype VBN cord-010092-uftc8inx 10362 8 for for IN cord-010092-uftc8inx 10362 9 RHD RHD NNP cord-010092-uftc8inx 10362 10 1227 1227 CD cord-010092-uftc8inx 10362 11 G g NN cord-010092-uftc8inx 10363 1 > > XX cord-010092-uftc8inx 10364 1 A a NN cord-010092-uftc8inx 10364 2 by by IN cord-010092-uftc8inx 10364 3 PCR PCR NNP cord-010092-uftc8inx 10364 4 with with IN cord-010092-uftc8inx 10364 5 T T NNP cord-010092-uftc8inx 10364 6 mshift mshift NN cord-010092-uftc8inx 10364 7 primers primer NNS cord-010092-uftc8inx 10364 8 . . . cord-010092-uftc8inx 10365 1 32 32 CD cord-010092-uftc8inx 10365 2 samples sample NNS cord-010092-uftc8inx 10365 3 were be VBD cord-010092-uftc8inx 10365 4 typed type VBN cord-010092-uftc8inx 10365 5 as as IN cord-010092-uftc8inx 10365 6 1227A+/G- 1227a+/g- CD cord-010092-uftc8inx 10365 7 , , , cord-010092-uftc8inx 10365 8 22 22 CD cord-010092-uftc8inx 10365 9 samples sample NNS cord-010092-uftc8inx 10365 10 were be VBD cord-010092-uftc8inx 10365 11 typed type VBN cord-010092-uftc8inx 10365 12 as as IN cord-010092-uftc8inx 10365 13 1227A-/G+ 1227a-/g+ CD cord-010092-uftc8inx 10365 14 , , , cord-010092-uftc8inx 10365 15 6 6 CD cord-010092-uftc8inx 10365 16 samples sample NNS cord-010092-uftc8inx 10365 17 were be VBD cord-010092-uftc8inx 10365 18 typed type VBN cord-010092-uftc8inx 10365 19 as as IN cord-010092-uftc8inx 10365 20 1227A+/G+ 1227a+/g+ CD cord-010092-uftc8inx 10365 21 and and CC cord-010092-uftc8inx 10365 22 24 24 CD cord-010092-uftc8inx 10365 23 samples sample NNS cord-010092-uftc8inx 10365 24 were be VBD cord-010092-uftc8inx 10365 25 typed type VBN cord-010092-uftc8inx 10365 26 as as IN cord-010092-uftc8inx 10365 27 1227A-/G- 1227a-/g- CD cord-010092-uftc8inx 10365 28 . . . cord-010092-uftc8inx 10366 1 Two two CD cord-010092-uftc8inx 10366 2 samples sample NNS cord-010092-uftc8inx 10366 3 typed type VBN cord-010092-uftc8inx 10366 4 as as IN cord-010092-uftc8inx 10366 5 1227A+/G+ 1227a+/g+ CD cord-010092-uftc8inx 10366 6 by by IN cord-010092-uftc8inx 10366 7 PCR PCR NNP cord-010092-uftc8inx 10366 8 - - HYPH cord-010092-uftc8inx 10366 9 SSP SSP NNP cord-010092-uftc8inx 10366 10 but but CC cord-010092-uftc8inx 10366 11 1227A+/G 1227A+/G NNP cord-010092-uftc8inx 10366 12 - - , cord-010092-uftc8inx 10366 13 by by IN cord-010092-uftc8inx 10366 14 PCR PCR NNP cord-010092-uftc8inx 10366 15 with with IN cord-010092-uftc8inx 10366 16 T T NNP cord-010092-uftc8inx 10366 17 m m NNP cord-010092-uftc8inx 10366 18 -shift -shift NN cord-010092-uftc8inx 10366 19 primers primer NNS cord-010092-uftc8inx 10366 20 were be VBD cord-010092-uftc8inx 10366 21 confirmed confirm VBN cord-010092-uftc8inx 10366 22 as as IN cord-010092-uftc8inx 10366 23 1227A+/G 1227a+/g CD cord-010092-uftc8inx 10366 24 - - HYPH cord-010092-uftc8inx 10366 25 by by IN cord-010092-uftc8inx 10366 26 RHD RHD NNP cord-010092-uftc8inx 10366 27 exon exon NN cord-010092-uftc8inx 10366 28 9 9 CD cord-010092-uftc8inx 10366 29 sequencing sequencing NN cord-010092-uftc8inx 10366 30 . . . cord-010092-uftc8inx 10367 1 Summary Summary NNP cord-010092-uftc8inx 10367 2 / / SYM cord-010092-uftc8inx 10367 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 10367 4 : : : cord-010092-uftc8inx 10368 1 The the DT cord-010092-uftc8inx 10368 2 single single JJ cord-010092-uftc8inx 10368 3 - - HYPH cord-010092-uftc8inx 10368 4 tube tube NN cord-010092-uftc8inx 10368 5 PCR PCR NNP cord-010092-uftc8inx 10368 6 with with IN cord-010092-uftc8inx 10368 7 T T NNP cord-010092-uftc8inx 10368 8 m m NN cord-010092-uftc8inx 10368 9 -shift -shift NN cord-010092-uftc8inx 10368 10 primers primer NNS cord-010092-uftc8inx 10368 11 for for IN cord-010092-uftc8inx 10368 12 RHD RHD NNP cord-010092-uftc8inx 10368 13 1227 1227 CD cord-010092-uftc8inx 10368 14 G g NN cord-010092-uftc8inx 10369 1 > > XX cord-010092-uftc8inx 10370 1 A a DT cord-010092-uftc8inx 10370 2 genotyping genotyping NN cord-010092-uftc8inx 10370 3 is be VBZ cord-010092-uftc8inx 10370 4 simple simple JJ cord-010092-uftc8inx 10370 5 , , , cord-010092-uftc8inx 10370 6 rapid rapid JJ cord-010092-uftc8inx 10370 7 , , , cord-010092-uftc8inx 10370 8 accurate accurate JJ cord-010092-uftc8inx 10370 9 , , , cord-010092-uftc8inx 10370 10 and and CC cord-010092-uftc8inx 10370 11 it -PRON- PRP cord-010092-uftc8inx 10370 12 is be VBZ cord-010092-uftc8inx 10370 13 superior superior JJ cord-010092-uftc8inx 10370 14 to to IN cord-010092-uftc8inx 10370 15 conventional conventional JJ cord-010092-uftc8inx 10370 16 PCR PCR NNP cord-010092-uftc8inx 10370 17 - - HYPH cord-010092-uftc8inx 10370 18 SSP SSP NNP cord-010092-uftc8inx 10370 19 . . . cord-010092-uftc8inx 10371 1 Abstract Abstract NNP cord-010092-uftc8inx 10371 2 withdrawn withdraw VBN cord-010092-uftc8inx 10371 3 . . . cord-010092-uftc8inx 10372 1 Background background NN cord-010092-uftc8inx 10372 2 : : : cord-010092-uftc8inx 10373 1 The the DT cord-010092-uftc8inx 10373 2 Rh Rh NNP cord-010092-uftc8inx 10373 3 blood blood NN cord-010092-uftc8inx 10373 4 group group NN cord-010092-uftc8inx 10373 5 system system NN cord-010092-uftc8inx 10373 6 has have VBZ cord-010092-uftc8inx 10373 7 numerous numerous JJ cord-010092-uftc8inx 10373 8 variant variant JJ cord-010092-uftc8inx 10373 9 alleles allele NNS cord-010092-uftc8inx 10373 10 , , , cord-010092-uftc8inx 10373 11 which which WDT cord-010092-uftc8inx 10373 12 may may MD cord-010092-uftc8inx 10373 13 affect affect VB cord-010092-uftc8inx 10373 14 Rh Rh NNP cord-010092-uftc8inx 10373 15 antigen antigen NN cord-010092-uftc8inx 10373 16 expression expression NN cord-010092-uftc8inx 10373 17 , , , cord-010092-uftc8inx 10373 18 including include VBG cord-010092-uftc8inx 10373 19 RHD RHD NNP cord-010092-uftc8inx 10373 20 - - HYPH cord-010092-uftc8inx 10373 21 RHCE RHCE NNP cord-010092-uftc8inx 10373 22 ( ( -LRB- cord-010092-uftc8inx 10373 23 D D NNP cord-010092-uftc8inx 10373 24 - - HYPH cord-010092-uftc8inx 10373 25 CE CE NNP cord-010092-uftc8inx 10373 26 ) ) -RRB- cord-010092-uftc8inx 10373 27 hybrid hybrid JJ cord-010092-uftc8inx 10373 28 genes gene NNS cord-010092-uftc8inx 10373 29 . . . cord-010092-uftc8inx 10374 1 These these DT cord-010092-uftc8inx 10374 2 variant variant JJ cord-010092-uftc8inx 10374 3 alleles allele NNS cord-010092-uftc8inx 10374 4 are be VBP cord-010092-uftc8inx 10374 5 frequently frequently RB cord-010092-uftc8inx 10374 6 found find VBN cord-010092-uftc8inx 10374 7 in in IN cord-010092-uftc8inx 10374 8 people people NNS cord-010092-uftc8inx 10374 9 of of IN cord-010092-uftc8inx 10374 10 African african JJ cord-010092-uftc8inx 10374 11 descent descent NN cord-010092-uftc8inx 10374 12 , , , cord-010092-uftc8inx 10374 13 and and CC cord-010092-uftc8inx 10374 14 typically typically RB cord-010092-uftc8inx 10374 15 result result VB cord-010092-uftc8inx 10374 16 in in IN cord-010092-uftc8inx 10374 17 either either DT cord-010092-uftc8inx 10374 18 D d JJ cord-010092-uftc8inx 10374 19 - - HYPH cord-010092-uftc8inx 10374 20 negative negative JJ cord-010092-uftc8inx 10374 21 ( ( -LRB- cord-010092-uftc8inx 10374 22 D- d- NN cord-010092-uftc8inx 10374 23 ) ) -RRB- cord-010092-uftc8inx 10374 24 phenotype phenotype NN cord-010092-uftc8inx 10374 25 , , , cord-010092-uftc8inx 10374 26 or or CC cord-010092-uftc8inx 10374 27 partial partial JJ cord-010092-uftc8inx 10374 28 D d NN cord-010092-uftc8inx 10374 29 antigen antigen NN cord-010092-uftc8inx 10374 30 expression expression NN cord-010092-uftc8inx 10374 31 , , , cord-010092-uftc8inx 10374 32 including include VBG cord-010092-uftc8inx 10374 33 silencing silence VBG cord-010092-uftc8inx 10374 34 of of IN cord-010092-uftc8inx 10374 35 high high JJ cord-010092-uftc8inx 10374 36 - - HYPH cord-010092-uftc8inx 10374 37 frequency frequency NN cord-010092-uftc8inx 10374 38 antigens antigen NNS cord-010092-uftc8inx 10374 39 and/or and/or CC cord-010092-uftc8inx 10374 40 expression expression NN cord-010092-uftc8inx 10374 41 of of IN cord-010092-uftc8inx 10374 42 low low JJ cord-010092-uftc8inx 10374 43 - - HYPH cord-010092-uftc8inx 10374 44 frequency frequency NN cord-010092-uftc8inx 10374 45 antigens antigen NNS cord-010092-uftc8inx 10374 46 . . . cord-010092-uftc8inx 10375 1 Patients patient NNS cord-010092-uftc8inx 10375 2 carrying carry VBG cord-010092-uftc8inx 10375 3 those those DT cord-010092-uftc8inx 10375 4 alleles allele NNS cord-010092-uftc8inx 10375 5 are be VBP cord-010092-uftc8inx 10375 6 particularly particularly RB cord-010092-uftc8inx 10375 7 at at IN cord-010092-uftc8inx 10375 8 risk risk NN cord-010092-uftc8inx 10375 9 of of IN cord-010092-uftc8inx 10375 10 alloimmunization alloimmunization NN cord-010092-uftc8inx 10375 11 , , , cord-010092-uftc8inx 10375 12 suggesting suggest VBG cord-010092-uftc8inx 10375 13 that that IN cord-010092-uftc8inx 10375 14 their -PRON- PRP$ cord-010092-uftc8inx 10375 15 identification identification NN cord-010092-uftc8inx 10375 16 is be VBZ cord-010092-uftc8inx 10375 17 important important JJ cord-010092-uftc8inx 10375 18 in in IN cord-010092-uftc8inx 10375 19 diagnostics diagnostic NNS cord-010092-uftc8inx 10375 20 . . . cord-010092-uftc8inx 10376 1 Quantitative quantitative JJ cord-010092-uftc8inx 10376 2 multiplex multiplex NN cord-010092-uftc8inx 10376 3 polymerase polymerase NN cord-010092-uftc8inx 10376 4 chain chain NN cord-010092-uftc8inx 10376 5 reaction reaction NN cord-010092-uftc8inx 10376 6 ( ( -LRB- cord-010092-uftc8inx 10376 7 PCR PCR NNP cord-010092-uftc8inx 10376 8 ) ) -RRB- cord-010092-uftc8inx 10376 9 of of IN cord-010092-uftc8inx 10376 10 short short JJ cord-010092-uftc8inx 10376 11 fluorescent fluorescent NN cord-010092-uftc8inx 10376 12 fragments fragment NNS cord-010092-uftc8inx 10376 13 ( ( -LRB- cord-010092-uftc8inx 10376 14 QMPSF QMPSF NNP cord-010092-uftc8inx 10376 15 ) ) -RRB- cord-010092-uftc8inx 10376 16 has have VBZ cord-010092-uftc8inx 10376 17 proven prove VBN cord-010092-uftc8inx 10376 18 successful successful JJ cord-010092-uftc8inx 10376 19 for for IN cord-010092-uftc8inx 10376 20 genotyping genotype VBG cord-010092-uftc8inx 10376 21 those those DT cord-010092-uftc8inx 10376 22 DNA dna NN cord-010092-uftc8inx 10376 23 samples sample NNS cord-010092-uftc8inx 10376 24 carrying carry VBG cord-010092-uftc8inx 10376 25 D D NNP cord-010092-uftc8inx 10376 26 - - HYPH cord-010092-uftc8inx 10376 27 CE CE NNP cord-010092-uftc8inx 10376 28 hybrid hybrid NN cord-010092-uftc8inx 10376 29 genes gene NNS cord-010092-uftc8inx 10376 30 by by IN cord-010092-uftc8inx 10376 31 assessing assess VBG cord-010092-uftc8inx 10376 32 both both CC cord-010092-uftc8inx 10376 33 qualitatively qualitatively RB cord-010092-uftc8inx 10376 34 and and CC cord-010092-uftc8inx 10376 35 quantitatively quantitatively RB cord-010092-uftc8inx 10376 36 RHD RHD NNP cord-010092-uftc8inx 10376 37 and and CC cord-010092-uftc8inx 10376 38 RHCE RHCE NNP cord-010092-uftc8inx 10376 39 gene gene NN cord-010092-uftc8inx 10376 40 exons exon NNS cord-010092-uftc8inx 10376 41 . . . cord-010092-uftc8inx 10377 1 Aims aim VBZ cord-010092-uftc8inx 10377 2 : : : cord-010092-uftc8inx 10378 1 The the DT cord-010092-uftc8inx 10378 2 aim aim NN cord-010092-uftc8inx 10378 3 of of IN cord-010092-uftc8inx 10378 4 this this DT cord-010092-uftc8inx 10378 5 project project NN cord-010092-uftc8inx 10378 6 was be VBD cord-010092-uftc8inx 10378 7 to to TO cord-010092-uftc8inx 10378 8 genotype genotype VB cord-010092-uftc8inx 10378 9 both both CC cord-010092-uftc8inx 10378 10 RH RH NNP cord-010092-uftc8inx 10378 11 genes gene NNS cord-010092-uftc8inx 10378 12 in in IN cord-010092-uftc8inx 10378 13 a a DT cord-010092-uftc8inx 10378 14 cohort cohort NN cord-010092-uftc8inx 10378 15 of of IN cord-010092-uftc8inx 10378 16 Brazilian brazilian JJ cord-010092-uftc8inx 10378 17 patients patient NNS cord-010092-uftc8inx 10378 18 with with IN cord-010092-uftc8inx 10378 19 sickle sickle NN cord-010092-uftc8inx 10378 20 cell cell NN cord-010092-uftc8inx 10378 21 disease disease NN cord-010092-uftc8inx 10378 22 ( ( -LRB- cord-010092-uftc8inx 10378 23 SCD SCD NNP cord-010092-uftc8inx 10378 24 ) ) -RRB- cord-010092-uftc8inx 10378 25 , , , cord-010092-uftc8inx 10378 26 which which WDT cord-010092-uftc8inx 10378 27 are be VBP cord-010092-uftc8inx 10378 28 known know VBN cord-010092-uftc8inx 10378 29 to to TO cord-010092-uftc8inx 10378 30 be be VB cord-010092-uftc8inx 10378 31 of of IN cord-010092-uftc8inx 10378 32 African african JJ cord-010092-uftc8inx 10378 33 descent descent NN cord-010092-uftc8inx 10378 34 , , , cord-010092-uftc8inx 10378 35 by by IN cord-010092-uftc8inx 10378 36 using use VBG cord-010092-uftc8inx 10378 37 the the DT cord-010092-uftc8inx 10378 38 QMPSF QMPSF NNP cord-010092-uftc8inx 10378 39 approach approach NN cord-010092-uftc8inx 10378 40 and and CC cord-010092-uftc8inx 10378 41 report report VB cord-010092-uftc8inx 10378 42 hybrid hybrid JJ cord-010092-uftc8inx 10378 43 gene gene NN cord-010092-uftc8inx 10378 44 variability variability NN cord-010092-uftc8inx 10378 45 in in IN cord-010092-uftc8inx 10378 46 this this DT cord-010092-uftc8inx 10378 47 population population NN cord-010092-uftc8inx 10378 48 . . . cord-010092-uftc8inx 10379 1 Methods method NNS cord-010092-uftc8inx 10379 2 : : : cord-010092-uftc8inx 10379 3 One one CD cord-010092-uftc8inx 10379 4 - - HYPH cord-010092-uftc8inx 10379 5 hundred hundred CD cord-010092-uftc8inx 10379 6 fifteen fifteen CD cord-010092-uftc8inx 10379 7 DNA dna NN cord-010092-uftc8inx 10379 8 samples sample NNS cord-010092-uftc8inx 10379 9 were be VBD cord-010092-uftc8inx 10379 10 selected select VBN cord-010092-uftc8inx 10379 11 for for IN cord-010092-uftc8inx 10379 12 the the DT cord-010092-uftc8inx 10379 13 study study NN cord-010092-uftc8inx 10379 14 and and CC cord-010092-uftc8inx 10379 15 analyzed analyze VBD cord-010092-uftc8inx 10379 16 prospectively prospectively RB cord-010092-uftc8inx 10379 17 by by IN cord-010092-uftc8inx 10379 18 the the DT cord-010092-uftc8inx 10379 19 RHD RHD NNP cord-010092-uftc8inx 10379 20 - - HYPH cord-010092-uftc8inx 10379 21 QMPSF QMPSF NNP cord-010092-uftc8inx 10379 22 and and CC cord-010092-uftc8inx 10379 23 RHCE RHCE NNP cord-010092-uftc8inx 10379 24 - - HYPH cord-010092-uftc8inx 10379 25 QMPSF QMPSF NNP cord-010092-uftc8inx 10379 26 approaches approach NNS cord-010092-uftc8inx 10379 27 to to TO cord-010092-uftc8inx 10379 28 investigate investigate VB cord-010092-uftc8inx 10379 29 the the DT cord-010092-uftc8inx 10379 30 copy copy NN cord-010092-uftc8inx 10379 31 number number NN cord-010092-uftc8inx 10379 32 of of IN cord-010092-uftc8inx 10379 33 all all DT cord-010092-uftc8inx 10379 34 exons exon NNS cord-010092-uftc8inx 10379 35 in in IN cord-010092-uftc8inx 10379 36 both both DT cord-010092-uftc8inx 10379 37 RH RH NNP cord-010092-uftc8inx 10379 38 genes gene NNS cord-010092-uftc8inx 10379 39 . . . cord-010092-uftc8inx 10380 1 Genotypes genotype NNS cord-010092-uftc8inx 10380 2 were be VBD cord-010092-uftc8inx 10380 3 further further RB cord-010092-uftc8inx 10380 4 confirmed confirm VBN cord-010092-uftc8inx 10380 5 or or CC cord-010092-uftc8inx 10380 6 investigated investigate VBN cord-010092-uftc8inx 10380 7 by by IN cord-010092-uftc8inx 10380 8 Sanger Sanger NNP cord-010092-uftc8inx 10380 9 sequencing sequencing NN cord-010092-uftc8inx 10380 10 and and CC cord-010092-uftc8inx 10380 11 conventional conventional JJ cord-010092-uftc8inx 10380 12 PCR pcr NN cord-010092-uftc8inx 10380 13 - - HYPH cord-010092-uftc8inx 10380 14 RFLP RFLP VBN cord-010092-uftc8inx 10380 15 assays assay NNS cord-010092-uftc8inx 10380 16 . . . cord-010092-uftc8inx 10381 1 Results result NNS cord-010092-uftc8inx 10381 2 : : : cord-010092-uftc8inx 10382 1 In in IN cord-010092-uftc8inx 10382 2 the the DT cord-010092-uftc8inx 10382 3 115 115 CD cord-010092-uftc8inx 10382 4 DNA dna NN cord-010092-uftc8inx 10382 5 samples sample NNS cord-010092-uftc8inx 10382 6 , , , cord-010092-uftc8inx 10382 7 75 75 CD cord-010092-uftc8inx 10382 8 ( ( -LRB- cord-010092-uftc8inx 10382 9 65.2 65.2 CD cord-010092-uftc8inx 10382 10 % % NN cord-010092-uftc8inx 10382 11 ) ) -RRB- cord-010092-uftc8inx 10382 12 exhibited exhibit VBD cord-010092-uftc8inx 10382 13 a a DT cord-010092-uftc8inx 10382 14 " " `` cord-010092-uftc8inx 10382 15 wild wild JJ cord-010092-uftc8inx 10382 16 - - HYPH cord-010092-uftc8inx 10382 17 type type NN cord-010092-uftc8inx 10382 18 " " '' cord-010092-uftc8inx 10382 19 profile profile NN cord-010092-uftc8inx 10382 20 by by IN cord-010092-uftc8inx 10382 21 QMPSF QMPSF NNP cord-010092-uftc8inx 10382 22 analysis analysis NN cord-010092-uftc8inx 10382 23 . . . cord-010092-uftc8inx 10383 1 Hybrid hybrid JJ cord-010092-uftc8inx 10383 2 genes gene NNS cord-010092-uftc8inx 10383 3 involving involve VBG cord-010092-uftc8inx 10383 4 exon exon NN cord-010092-uftc8inx 10383 5 8 8 CD cord-010092-uftc8inx 10383 6 , , , cord-010092-uftc8inx 10383 7 which which WDT cord-010092-uftc8inx 10383 8 is be VBZ cord-010092-uftc8inx 10383 9 functionally functionally RB cord-010092-uftc8inx 10383 10 not not RB cord-010092-uftc8inx 10383 11 relevant relevant JJ cord-010092-uftc8inx 10383 12 as as IN cord-010092-uftc8inx 10383 13 reported report VBN cord-010092-uftc8inx 10383 14 before before RB cord-010092-uftc8inx 10383 15 , , , cord-010092-uftc8inx 10383 16 was be VBD cord-010092-uftc8inx 10383 17 found find VBN cord-010092-uftc8inx 10383 18 in in IN cord-010092-uftc8inx 10383 19 28 28 CD cord-010092-uftc8inx 10383 20 samples sample NNS cord-010092-uftc8inx 10383 21 , , , cord-010092-uftc8inx 10383 22 including include VBG cord-010092-uftc8inx 10383 23 11 11 CD cord-010092-uftc8inx 10383 24 and and CC cord-010092-uftc8inx 10383 25 17 17 CD cord-010092-uftc8inx 10383 26 samples sample NNS cord-010092-uftc8inx 10383 27 carrying carry VBG cord-010092-uftc8inx 10383 28 respectively respectively RB cord-010092-uftc8inx 10383 29 RHD RHD NNP cord-010092-uftc8inx 10383 30 - - HYPH cord-010092-uftc8inx 10383 31 CE(8)-D CE(8)-D NNP cord-010092-uftc8inx 10383 32 and and CC cord-010092-uftc8inx 10383 33 RHCE RHCE NNP cord-010092-uftc8inx 10383 34 - - HYPH cord-010092-uftc8inx 10383 35 D(8)-CE D(8)-CE NNP cord-010092-uftc8inx 10383 36 ( ( -LRB- cord-010092-uftc8inx 10383 37 two two CD cord-010092-uftc8inx 10383 38 homozygous homozygous JJ cord-010092-uftc8inx 10383 39 each each DT cord-010092-uftc8inx 10383 40 ) ) -RRB- cord-010092-uftc8inx 10383 41 . . . cord-010092-uftc8inx 10384 1 Except except IN cord-010092-uftc8inx 10384 2 two two CD cord-010092-uftc8inx 10384 3 samples sample NNS cord-010092-uftc8inx 10384 4 that that WDT cord-010092-uftc8inx 10384 5 require require VBP cord-010092-uftc8inx 10384 6 additional additional JJ cord-010092-uftc8inx 10384 7 studies study NNS cord-010092-uftc8inx 10384 8 ( ( -LRB- cord-010092-uftc8inx 10384 9 1.7 1.7 CD cord-010092-uftc8inx 10384 10 % % NN cord-010092-uftc8inx 10384 11 ) ) -RRB- cord-010092-uftc8inx 10384 12 , , , cord-010092-uftc8inx 10384 13 RHD RHD NNP cord-010092-uftc8inx 10384 14 zygosity zygosity NN cord-010092-uftc8inx 10384 15 was be VBD cord-010092-uftc8inx 10384 16 resolved resolve VBN cord-010092-uftc8inx 10384 17 successfully successfully RB cord-010092-uftc8inx 10384 18 : : : cord-010092-uftc8inx 10384 19 60 60 CD cord-010092-uftc8inx 10384 20 ( ( -LRB- cord-010092-uftc8inx 10384 21 n n NN cord-010092-uftc8inx 10384 22 = = SYM cord-010092-uftc8inx 10384 23 2 2 CD cord-010092-uftc8inx 10384 24 RHD RHD NNP cord-010092-uftc8inx 10384 25 gene gene NN cord-010092-uftc8inx 10384 26 copies copy NNS cord-010092-uftc8inx 10384 27 ; ; : cord-010092-uftc8inx 10384 28 52.2 52.2 CD cord-010092-uftc8inx 10384 29 % % NN cord-010092-uftc8inx 10384 30 ) ) -RRB- cord-010092-uftc8inx 10384 31 , , , cord-010092-uftc8inx 10384 32 49 49 CD cord-010092-uftc8inx 10384 33 ( ( -LRB- cord-010092-uftc8inx 10384 34 1 1 CD cord-010092-uftc8inx 10384 35 ; ; : cord-010092-uftc8inx 10384 36 42.6 42.6 CD cord-010092-uftc8inx 10384 37 % % NN cord-010092-uftc8inx 10384 38 ) ) -RRB- cord-010092-uftc8inx 10384 39 and and CC cord-010092-uftc8inx 10384 40 4 4 LS cord-010092-uftc8inx 10384 41 ( ( -LRB- cord-010092-uftc8inx 10384 42 0 0 CD cord-010092-uftc8inx 10384 43 ; ; : cord-010092-uftc8inx 10384 44 3.5 3.5 CD cord-010092-uftc8inx 10384 45 % % NN cord-010092-uftc8inx 10384 46 ) ) -RRB- cord-010092-uftc8inx 10384 47 . . . cord-010092-uftc8inx 10385 1 Clinically clinically RB cord-010092-uftc8inx 10385 2 relevant relevant JJ cord-010092-uftc8inx 10385 3 , , , cord-010092-uftc8inx 10385 4 i.e. i.e. FW cord-010092-uftc8inx 10385 5 partial partial JJ cord-010092-uftc8inx 10385 6 D d NN cord-010092-uftc8inx 10385 7 , , , cord-010092-uftc8inx 10385 8 genotypes genotype NNS cord-010092-uftc8inx 10385 9 were be VBD cord-010092-uftc8inx 10385 10 identified identify VBN cord-010092-uftc8inx 10385 11 in in IN cord-010092-uftc8inx 10385 12 four four CD cord-010092-uftc8inx 10385 13 hemizygous hemizygous JJ cord-010092-uftc8inx 10385 14 samples sample NNS cord-010092-uftc8inx 10385 15 ( ( -LRB- cord-010092-uftc8inx 10385 16 4/115 4/115 CD cord-010092-uftc8inx 10385 17 , , , cord-010092-uftc8inx 10385 18 3.5 3.5 CD cord-010092-uftc8inx 10385 19 % % NN cord-010092-uftc8inx 10385 20 ) ) -RRB- cord-010092-uftc8inx 10385 21 carrying carry VBG cord-010092-uftc8inx 10385 22 RHD*DAU5 RHD*DAU5 NNS cord-010092-uftc8inx 10385 23 , , , cord-010092-uftc8inx 10385 24 RHD*DV.2 RHD*DV.2 NNP cord-010092-uftc8inx 10385 25 , , , cord-010092-uftc8inx 10385 26 a a DT cord-010092-uftc8inx 10385 27 RHD*DIIIa rhd*diiia NN cord-010092-uftc8inx 10385 28 - - HYPH cord-010092-uftc8inx 10385 29 like like JJ cord-010092-uftc8inx 10385 30 allele allele NN cord-010092-uftc8inx 10385 31 , , , cord-010092-uftc8inx 10385 32 and and CC cord-010092-uftc8inx 10385 33 a a DT cord-010092-uftc8inx 10385 34 novel novel JJ cord-010092-uftc8inx 10385 35 RHD*D rhd*d NN cord-010092-uftc8inx 10385 36 - - HYPH cord-010092-uftc8inx 10385 37 CE(7 CE(7 NNP cord-010092-uftc8inx 10385 38 : : : cord-010092-uftc8inx 10386 1 G329H G329H NNS cord-010092-uftc8inx 10386 2 - - HYPH cord-010092-uftc8inx 10386 3 Y330S Y330S NNP cord-010092-uftc8inx 10386 4 - - HYPH cord-010092-uftc8inx 10386 5 N331I)-D N331I)-D NNP cord-010092-uftc8inx 10386 6 allele allele NN cord-010092-uftc8inx 10386 7 , , , cord-010092-uftc8inx 10386 8 as as IN cord-010092-uftc8inx 10386 9 confirmed confirm VBN cord-010092-uftc8inx 10386 10 by by IN cord-010092-uftc8inx 10386 11 sequencing sequence VBG cord-010092-uftc8inx 10386 12 . . . cord-010092-uftc8inx 10387 1 Other other JJ cord-010092-uftc8inx 10387 2 hybrid hybrid NN cord-010092-uftc8inx 10387 3 alleles allele NNS cord-010092-uftc8inx 10387 4 , , , cord-010092-uftc8inx 10387 5 such such JJ cord-010092-uftc8inx 10387 6 as as IN cord-010092-uftc8inx 10387 7 RHD*03N.01 rhd*03n.01 CD cord-010092-uftc8inx 10387 8 and and CC cord-010092-uftc8inx 10387 9 RHD*DIIIc RHD*DIIIc NNP cord-010092-uftc8inx 10387 10 , , , cord-010092-uftc8inx 10387 11 were be VBD cord-010092-uftc8inx 10387 12 also also RB cord-010092-uftc8inx 10387 13 found find VBN cord-010092-uftc8inx 10387 14 in in IN cord-010092-uftc8inx 10387 15 trans trans NNP cord-010092-uftc8inx 10387 16 with with IN cord-010092-uftc8inx 10387 17 a a DT cord-010092-uftc8inx 10387 18 normal normal JJ cord-010092-uftc8inx 10387 19 RHD*01 rhd*01 NN cord-010092-uftc8inx 10387 20 allele allele NN cord-010092-uftc8inx 10387 21 . . . cord-010092-uftc8inx 10388 1 In in IN cord-010092-uftc8inx 10388 2 RHCE RHCE NNP cord-010092-uftc8inx 10388 3 , , , cord-010092-uftc8inx 10388 4 C C NNP cord-010092-uftc8inx 10388 5 / / SYM cord-010092-uftc8inx 10388 6 c c NN cord-010092-uftc8inx 10388 7 genotype genotype NN cord-010092-uftc8inx 10388 8 could could MD cord-010092-uftc8inx 10388 9 be be VB cord-010092-uftc8inx 10388 10 resolved resolve VBN cord-010092-uftc8inx 10388 11 . . . cord-010092-uftc8inx 10389 1 The the DT cord-010092-uftc8inx 10389 2 RHCE*ce16 RHCE*ce16 NNS cord-010092-uftc8inx 10389 3 ( ( -LRB- cord-010092-uftc8inx 10389 4 RHCE*ce rhce*ce JJ cord-010092-uftc8inx 10389 5 ( ( -LRB- cord-010092-uftc8inx 10389 6 48C)-D(9)-ce 48c)-d(9)-ce CD cord-010092-uftc8inx 10389 7 ) ) -RRB- cord-010092-uftc8inx 10389 8 allele allele NN cord-010092-uftc8inx 10389 9 , , , cord-010092-uftc8inx 10389 10 which which WDT cord-010092-uftc8inx 10389 11 is be VBZ cord-010092-uftc8inx 10389 12 commonly commonly RB cord-010092-uftc8inx 10389 13 cis cis NNP cord-010092-uftc8inx 10389 14 - - HYPH cord-010092-uftc8inx 10389 15 associated associate VBN cord-010092-uftc8inx 10389 16 with with IN cord-010092-uftc8inx 10389 17 RHD*Ψ RHD*Ψ NNP cord-010092-uftc8inx 10389 18 , , , cord-010092-uftc8inx 10389 19 was be VBD cord-010092-uftc8inx 10389 20 observed observe VBN cord-010092-uftc8inx 10389 21 in in IN cord-010092-uftc8inx 10389 22 four four CD cord-010092-uftc8inx 10389 23 samples sample NNS cord-010092-uftc8inx 10389 24 . . . cord-010092-uftc8inx 10390 1 However however RB cord-010092-uftc8inx 10390 2 the the DT cord-010092-uftc8inx 10390 3 clinically clinically RB cord-010092-uftc8inx 10390 4 relevant relevant JJ cord-010092-uftc8inx 10390 5 polymorphisms polymorphism NNS cord-010092-uftc8inx 10390 6 in in IN cord-010092-uftc8inx 10390 7 variant variant JJ cord-010092-uftc8inx 10390 8 RHCE RHCE NNP cord-010092-uftc8inx 10390 9 alleles allele NNS cord-010092-uftc8inx 10390 10 , , , cord-010092-uftc8inx 10390 11 such such JJ cord-010092-uftc8inx 10390 12 as as IN cord-010092-uftc8inx 10390 13 those those DT cord-010092-uftc8inx 10390 14 involved involve VBN cord-010092-uftc8inx 10390 15 in in IN cord-010092-uftc8inx 10390 16 ceMO cemo NN cord-010092-uftc8inx 10390 17 , , , cord-010092-uftc8inx 10390 18 ceAR ceAR NNP cord-010092-uftc8inx 10390 19 , , , cord-010092-uftc8inx 10390 20 ceAG ceAG NNP cord-010092-uftc8inx 10390 21 , , , cord-010092-uftc8inx 10390 22 and and CC cord-010092-uftc8inx 10390 23 ceTI ceti NN cord-010092-uftc8inx 10390 24 , , , cord-010092-uftc8inx 10390 25 were be VBD cord-010092-uftc8inx 10390 26 mostly mostly RB cord-010092-uftc8inx 10390 27 identified identify VBN cord-010092-uftc8inx 10390 28 by by IN cord-010092-uftc8inx 10390 29 other other JJ cord-010092-uftc8inx 10390 30 standard standard JJ cord-010092-uftc8inx 10390 31 methods method NNS cord-010092-uftc8inx 10390 32 . . . cord-010092-uftc8inx 10391 1 Summary Summary NNP cord-010092-uftc8inx 10391 2 / / SYM cord-010092-uftc8inx 10391 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 10391 4 : : : cord-010092-uftc8inx 10392 1 Although although IN cord-010092-uftc8inx 10392 2 most most JJS cord-010092-uftc8inx 10392 3 of of IN cord-010092-uftc8inx 10392 4 the the DT cord-010092-uftc8inx 10392 5 Brazilian brazilian JJ cord-010092-uftc8inx 10392 6 patients patient NNS cord-010092-uftc8inx 10392 7 with with IN cord-010092-uftc8inx 10392 8 SCD SCD NNP cord-010092-uftc8inx 10392 9 investigated investigate VBN cord-010092-uftc8inx 10392 10 in in IN cord-010092-uftc8inx 10392 11 this this DT cord-010092-uftc8inx 10392 12 study study NN cord-010092-uftc8inx 10392 13 did do VBD cord-010092-uftc8inx 10392 14 not not RB cord-010092-uftc8inx 10392 15 carry carry VB cord-010092-uftc8inx 10392 16 RHD RHD NNP cord-010092-uftc8inx 10392 17 - - HYPH cord-010092-uftc8inx 10392 18 RHCE RHCE NNP cord-010092-uftc8inx 10392 19 hybrid hybrid NN cord-010092-uftc8inx 10392 20 genes gene NNS cord-010092-uftc8inx 10392 21 , , , cord-010092-uftc8inx 10392 22 QMPSF QMPSF NNP cord-010092-uftc8inx 10392 23 analysis analysis NN cord-010092-uftc8inx 10392 24 has have VBZ cord-010092-uftc8inx 10392 25 been be VBN cord-010092-uftc8inx 10392 26 shown show VBN cord-010092-uftc8inx 10392 27 to to TO cord-010092-uftc8inx 10392 28 be be VB cord-010092-uftc8inx 10392 29 an an DT cord-010092-uftc8inx 10392 30 efficient efficient JJ cord-010092-uftc8inx 10392 31 tool tool NN cord-010092-uftc8inx 10392 32 in in IN cord-010092-uftc8inx 10392 33 the the DT cord-010092-uftc8inx 10392 34 whole whole JJ cord-010092-uftc8inx 10392 35 genotyping genotyping NN cord-010092-uftc8inx 10392 36 process process NN cord-010092-uftc8inx 10392 37 to to TO cord-010092-uftc8inx 10392 38 investigate investigate VB cord-010092-uftc8inx 10392 39 RH RH NNP cord-010092-uftc8inx 10392 40 gene gene NN cord-010092-uftc8inx 10392 41 variation variation NN cord-010092-uftc8inx 10392 42 . . . cord-010092-uftc8inx 10393 1 As as IN cord-010092-uftc8inx 10393 2 previously previously RB cord-010092-uftc8inx 10393 3 reported report VBN cord-010092-uftc8inx 10393 4 , , , cord-010092-uftc8inx 10393 5 it -PRON- PRP cord-010092-uftc8inx 10393 6 has have VBZ cord-010092-uftc8inx 10393 7 been be VBN cord-010092-uftc8inx 10393 8 conclusive conclusive JJ cord-010092-uftc8inx 10393 9 for for IN cord-010092-uftc8inx 10393 10 characterization characterization NN cord-010092-uftc8inx 10393 11 of of IN cord-010092-uftc8inx 10393 12 RHD RHD NNP cord-010092-uftc8inx 10393 13 zygosity zygosity NN cord-010092-uftc8inx 10393 14 and and CC cord-010092-uftc8inx 10393 15 identification identification NN cord-010092-uftc8inx 10393 16 of of IN cord-010092-uftc8inx 10393 17 rare rare JJ cord-010092-uftc8inx 10393 18 , , , cord-010092-uftc8inx 10393 19 as as RB cord-010092-uftc8inx 10393 20 well well RB cord-010092-uftc8inx 10393 21 as as IN cord-010092-uftc8inx 10393 22 novel novel NN cord-010092-uftc8inx 10393 23 , , , cord-010092-uftc8inx 10393 24 variant variant NN cord-010092-uftc8inx 10393 25 alleles allele NNS cord-010092-uftc8inx 10393 26 . . . cord-010092-uftc8inx 10394 1 Additionally additionally RB cord-010092-uftc8inx 10394 2 , , , cord-010092-uftc8inx 10394 3 our -PRON- PRP$ cord-010092-uftc8inx 10394 4 results result NNS cord-010092-uftc8inx 10394 5 show show VBP cord-010092-uftc8inx 10394 6 a a DT cord-010092-uftc8inx 10394 7 large large JJ cord-010092-uftc8inx 10394 8 diversity diversity NN cord-010092-uftc8inx 10394 9 of of IN cord-010092-uftc8inx 10394 10 hybrid hybrid JJ cord-010092-uftc8inx 10394 11 genes gene NNS cord-010092-uftc8inx 10394 12 among among IN cord-010092-uftc8inx 10394 13 the the DT cord-010092-uftc8inx 10394 14 Brazilian brazilian JJ cord-010092-uftc8inx 10394 15 patients patient NNS cord-010092-uftc8inx 10394 16 with with IN cord-010092-uftc8inx 10394 17 SCD SCD NNP cord-010092-uftc8inx 10394 18 . . . cord-010092-uftc8inx 10395 1 Therefore therefore RB cord-010092-uftc8inx 10395 2 , , , cord-010092-uftc8inx 10395 3 we -PRON- PRP cord-010092-uftc8inx 10395 4 suggest suggest VBP cord-010092-uftc8inx 10395 5 that that IN cord-010092-uftc8inx 10395 6 QMPSF QMPSF NNP cord-010092-uftc8inx 10395 7 may may MD cord-010092-uftc8inx 10395 8 be be VB cord-010092-uftc8inx 10395 9 used use VBN cord-010092-uftc8inx 10395 10 as as IN cord-010092-uftc8inx 10395 11 a a DT cord-010092-uftc8inx 10395 12 complementary complementary JJ cord-010092-uftc8inx 10395 13 screening screening NN cord-010092-uftc8inx 10395 14 approach approach NN cord-010092-uftc8inx 10395 15 for for IN cord-010092-uftc8inx 10395 16 assessing assess VBG cord-010092-uftc8inx 10395 17 RH RH NNP cord-010092-uftc8inx 10395 18 genotype genotype NN cord-010092-uftc8inx 10395 19 in in IN cord-010092-uftc8inx 10395 20 selected select VBN cord-010092-uftc8inx 10395 21 patients patient NNS cord-010092-uftc8inx 10395 22 and and CC cord-010092-uftc8inx 10395 23 donors donor NNS cord-010092-uftc8inx 10395 24 . . . cord-010092-uftc8inx 10396 1 = = SYM cord-010092-uftc8inx 10396 2 19 19 CD cord-010092-uftc8inx 10396 3 ) ) -RRB- cord-010092-uftc8inx 10396 4 vs. vs. FW cord-010092-uftc8inx 10396 5 non non JJ cord-010092-uftc8inx 10396 6 - - JJ cord-010092-uftc8inx 10396 7 bleeding bleeding JJ cord-010092-uftc8inx 10396 8 ( ( -LRB- cord-010092-uftc8inx 10396 9 n n NN cord-010092-uftc8inx 10396 10 = = SYM cord-010092-uftc8inx 10396 11 15 15 CD cord-010092-uftc8inx 10396 12 ) ) -RRB- cord-010092-uftc8inx 10396 13 patients patient NNS cord-010092-uftc8inx 10396 14 . . . cord-010092-uftc8inx 10397 1 Platelet platelet NN cord-010092-uftc8inx 10397 2 , , , cord-010092-uftc8inx 10397 3 PMP PMP NNP cord-010092-uftc8inx 10397 4 and and CC cord-010092-uftc8inx 10397 5 CP CP NNP cord-010092-uftc8inx 10397 6 phenotype phenotype NN cord-010092-uftc8inx 10397 7 and and CC cord-010092-uftc8inx 10397 8 function function NN cord-010092-uftc8inx 10397 9 were be VBD cord-010092-uftc8inx 10397 10 evaluated evaluate VBN cord-010092-uftc8inx 10397 11 by by IN cord-010092-uftc8inx 10397 12 flow flow NN cord-010092-uftc8inx 10397 13 cytometry cytometry NN cord-010092-uftc8inx 10397 14 : : : cord-010092-uftc8inx 10398 1 Activation activation NN cord-010092-uftc8inx 10398 2 and and CC cord-010092-uftc8inx 10398 3 granule granule NN cord-010092-uftc8inx 10398 4 release release NN cord-010092-uftc8inx 10398 5 were be VBD cord-010092-uftc8inx 10398 6 examined examine VBN cord-010092-uftc8inx 10398 7 by by IN cord-010092-uftc8inx 10398 8 antibodies antibody NNS cord-010092-uftc8inx 10398 9 against against IN cord-010092-uftc8inx 10398 10 granulphysin granulphysin NNP cord-010092-uftc8inx 10398 11 ( ( -LRB- cord-010092-uftc8inx 10398 12 CD63 CD63 NNP cord-010092-uftc8inx 10398 13 ) ) -RRB- cord-010092-uftc8inx 10398 14 , , , cord-010092-uftc8inx 10398 15 P p NN cord-010092-uftc8inx 10398 16 - - HYPH cord-010092-uftc8inx 10398 17 selectin selectin NNP cord-010092-uftc8inx 10398 18 ( ( -LRB- cord-010092-uftc8inx 10398 19 CD62P CD62P NNP cord-010092-uftc8inx 10398 20 ) ) -RRB- cord-010092-uftc8inx 10398 21 , , , cord-010092-uftc8inx 10398 22 activated activate VBN cord-010092-uftc8inx 10398 23 GPIIb GPIIb NNP cord-010092-uftc8inx 10398 24 / / SYM cord-010092-uftc8inx 10398 25 IIIa iiia NN cord-010092-uftc8inx 10398 26 ( ( -LRB- cord-010092-uftc8inx 10398 27 PAC-1 PAC-1 NNP cord-010092-uftc8inx 10398 28 ) ) -RRB- cord-010092-uftc8inx 10398 29 and and CC cord-010092-uftc8inx 10398 30 phosphatidylserine phosphatidylserine NN cord-010092-uftc8inx 10398 31 ( ( -LRB- cord-010092-uftc8inx 10398 32 PS PS NNP cord-010092-uftc8inx 10398 33 ) ) -RRB- cord-010092-uftc8inx 10398 34 ( ( -LRB- cord-010092-uftc8inx 10398 35 lactadherin lactadherin NNP cord-010092-uftc8inx 10398 36 ) ) -RRB- cord-010092-uftc8inx 10398 37 unstimulated unstimulated JJ cord-010092-uftc8inx 10398 38 and and CC cord-010092-uftc8inx 10398 39 ADP ADP NNP cord-010092-uftc8inx 10398 40 , , , cord-010092-uftc8inx 10398 41 TRAP trap NN cord-010092-uftc8inx 10398 42 or or CC cord-010092-uftc8inx 10398 43 collagen collagen NN cord-010092-uftc8inx 10398 44 stimulated stimulate VBD cord-010092-uftc8inx 10398 45 . . . cord-010092-uftc8inx 10399 1 Coated coated JJ cord-010092-uftc8inx 10399 2 platelets platelet NNS cord-010092-uftc8inx 10399 3 were be VBD cord-010092-uftc8inx 10399 4 identified identify VBN cord-010092-uftc8inx 10399 5 as as IN cord-010092-uftc8inx 10399 6 a a DT cord-010092-uftc8inx 10399 7 highly highly RB cord-010092-uftc8inx 10399 8 granulated granulated JJ cord-010092-uftc8inx 10399 9 independent independent JJ cord-010092-uftc8inx 10399 10 cell cell NN cord-010092-uftc8inx 10399 11 population population NN cord-010092-uftc8inx 10399 12 appearing appear VBG cord-010092-uftc8inx 10399 13 following follow VBG cord-010092-uftc8inx 10399 14 collagen collagen NN cord-010092-uftc8inx 10399 15 stimulation stimulation NN cord-010092-uftc8inx 10399 16 , , , cord-010092-uftc8inx 10399 17 gated gate VBN cord-010092-uftc8inx 10399 18 on on IN cord-010092-uftc8inx 10399 19 side side JJ cord-010092-uftc8inx 10399 20 scatter scatter NN cord-010092-uftc8inx 10399 21 and and CC cord-010092-uftc8inx 10399 22 GPIba GPIba NNP cord-010092-uftc8inx 10399 23 ( ( -LRB- cord-010092-uftc8inx 10399 24 CD42b CD42b NNP cord-010092-uftc8inx 10399 25 ) ) -RRB- cord-010092-uftc8inx 10399 26 . . . cord-010092-uftc8inx 10400 1 Normal normal JJ cord-010092-uftc8inx 10400 2 healthy healthy JJ cord-010092-uftc8inx 10400 3 reference reference NN cord-010092-uftc8inx 10400 4 levels level NNS cord-010092-uftc8inx 10400 5 were be VBD cord-010092-uftc8inx 10400 6 available available JJ cord-010092-uftc8inx 10400 7 . . . cord-010092-uftc8inx 10401 1 Results result NNS cord-010092-uftc8inx 10401 2 : : : cord-010092-uftc8inx 10402 1 The the DT cord-010092-uftc8inx 10402 2 platelet platelet NN cord-010092-uftc8inx 10402 3 count count NN cord-010092-uftc8inx 10402 4 in in IN cord-010092-uftc8inx 10402 5 bleeding bleed VBG cord-010092-uftc8inx 10402 6 ( ( -LRB- cord-010092-uftc8inx 10402 7 72 72 CD cord-010092-uftc8inx 10402 8 9 9 CD cord-010092-uftc8inx 10402 9 10 10 CD cord-010092-uftc8inx 10402 10 9 9 CD cord-010092-uftc8inx 10402 11 /l /l NN cord-010092-uftc8inx 10402 12 ) ) -RRB- cord-010092-uftc8inx 10402 13 and and CC cord-010092-uftc8inx 10402 14 non non JJ cord-010092-uftc8inx 10402 15 - - JJ cord-010092-uftc8inx 10402 16 bleeding bleeding JJ cord-010092-uftc8inx 10402 17 ( ( -LRB- cord-010092-uftc8inx 10402 18 68 68 CD cord-010092-uftc8inx 10402 19 9 9 CD cord-010092-uftc8inx 10402 20 10 10 CD cord-010092-uftc8inx 10402 21 9 9 CD cord-010092-uftc8inx 10402 22 /l /l NN cord-010092-uftc8inx 10402 23 ) ) -RRB- cord-010092-uftc8inx 10402 24 patients patient NNS cord-010092-uftc8inx 10402 25 was be VBD cord-010092-uftc8inx 10402 26 comparable comparable JJ cord-010092-uftc8inx 10402 27 ( ( -LRB- cord-010092-uftc8inx 10402 28 P p NN cord-010092-uftc8inx 10402 29 = = SYM cord-010092-uftc8inx 10402 30 0,66 0,66 CD cord-010092-uftc8inx 10402 31 ) ) -RRB- cord-010092-uftc8inx 10402 32 . . . cord-010092-uftc8inx 10403 1 Bleeding bleed VBG cord-010092-uftc8inx 10403 2 patients patient NNS cord-010092-uftc8inx 10403 3 had have VBD cord-010092-uftc8inx 10403 4 a a DT cord-010092-uftc8inx 10403 5 higher high JJR cord-010092-uftc8inx 10403 6 BAT bat NN cord-010092-uftc8inx 10403 7 score score NN cord-010092-uftc8inx 10403 8 compared compare VBN cord-010092-uftc8inx 10403 9 to to IN cord-010092-uftc8inx 10403 10 non non JJ cord-010092-uftc8inx 10403 11 - - JJ cord-010092-uftc8inx 10403 12 bleeding bleeding JJ cord-010092-uftc8inx 10403 13 patients patient NNS cord-010092-uftc8inx 10403 14 ( ( -LRB- cord-010092-uftc8inx 10403 15 10 10 CD cord-010092-uftc8inx 10403 16 vs. vs. NN cord-010092-uftc8inx 10403 17 2 2 CD cord-010092-uftc8inx 10403 18 , , , cord-010092-uftc8inx 10403 19 P p NN cord-010092-uftc8inx 10403 20 < < XX cord-010092-uftc8inx 10403 21 0,01 0,01 NN cord-010092-uftc8inx 10403 22 ) ) -RRB- cord-010092-uftc8inx 10403 23 . . . cord-010092-uftc8inx 10404 1 The the DT cord-010092-uftc8inx 10404 2 proportion proportion NN cord-010092-uftc8inx 10404 3 of of IN cord-010092-uftc8inx 10404 4 CPs cp NNS cord-010092-uftc8inx 10404 5 was be VBD cord-010092-uftc8inx 10404 6 normal normal JJ cord-010092-uftc8inx 10404 7 in in IN cord-010092-uftc8inx 10404 8 all all DT cord-010092-uftc8inx 10404 9 patients patient NNS cord-010092-uftc8inx 10404 10 . . . cord-010092-uftc8inx 10405 1 However however RB cord-010092-uftc8inx 10405 2 , , , cord-010092-uftc8inx 10405 3 in in IN cord-010092-uftc8inx 10405 4 non non JJ cord-010092-uftc8inx 10405 5 - - JJ cord-010092-uftc8inx 10405 6 bleeding bleeding JJ cord-010092-uftc8inx 10405 7 patients patient NNS cord-010092-uftc8inx 10405 8 the the DT cord-010092-uftc8inx 10405 9 proportion proportion NN cord-010092-uftc8inx 10405 10 of of IN cord-010092-uftc8inx 10405 11 PS+CPs ps+cp NNS cord-010092-uftc8inx 10405 12 and and CC cord-010092-uftc8inx 10405 13 per per IN cord-010092-uftc8inx 10405 14 cell cell NN cord-010092-uftc8inx 10405 15 PS ps NN cord-010092-uftc8inx 10405 16 expression expression NN cord-010092-uftc8inx 10405 17 ( ( -LRB- cord-010092-uftc8inx 10405 18 MFI MFI NNP cord-010092-uftc8inx 10405 19 ) ) -RRB- cord-010092-uftc8inx 10405 20 ( ( -LRB- cord-010092-uftc8inx 10405 21 86,16 86,16 CD cord-010092-uftc8inx 10405 22 % % NN cord-010092-uftc8inx 10405 23 and and CC cord-010092-uftc8inx 10405 24 4,96MFI 4,96mfi CD cord-010092-uftc8inx 10405 25 ) ) -RRB- cord-010092-uftc8inx 10405 26 were be VBD cord-010092-uftc8inx 10405 27 higher high JJR cord-010092-uftc8inx 10405 28 , , , cord-010092-uftc8inx 10405 29 compared compare VBN cord-010092-uftc8inx 10405 30 to to IN cord-010092-uftc8inx 10405 31 bleeding bleed VBG cord-010092-uftc8inx 10405 32 patients patient NNS cord-010092-uftc8inx 10405 33 ( ( -LRB- cord-010092-uftc8inx 10405 34 64,08 64,08 CD cord-010092-uftc8inx 10405 35 % % NN cord-010092-uftc8inx 10405 36 and and CC cord-010092-uftc8inx 10405 37 2,44MFI 2,44mfi CD cord-010092-uftc8inx 10405 38 , , , cord-010092-uftc8inx 10405 39 both both DT cord-010092-uftc8inx 10405 40 P p NN cord-010092-uftc8inx 10405 41 < < XX cord-010092-uftc8inx 10405 42 0,05 0,05 NNP cord-010092-uftc8inx 10405 43 ) ) -RRB- cord-010092-uftc8inx 10405 44 , , , cord-010092-uftc8inx 10405 45 and and CC cord-010092-uftc8inx 10405 46 the the DT cord-010092-uftc8inx 10405 47 proportion proportion NN cord-010092-uftc8inx 10405 48 of of IN cord-010092-uftc8inx 10405 49 PS+CPs ps+cp NNS cord-010092-uftc8inx 10405 50 correlated correlate VBN cord-010092-uftc8inx 10405 51 negatively negatively RB cord-010092-uftc8inx 10405 52 with with IN cord-010092-uftc8inx 10405 53 BAT bat NN cord-010092-uftc8inx 10405 54 score score NN cord-010092-uftc8inx 10405 55 ( ( -LRB- cord-010092-uftc8inx 10405 56 r r NN cord-010092-uftc8inx 10405 57 2 2 CD cord-010092-uftc8inx 10405 58 = = SYM cord-010092-uftc8inx 10405 59 0,26 0,26 CD cord-010092-uftc8inx 10405 60 , , , cord-010092-uftc8inx 10406 1 P p NN cord-010092-uftc8inx 10406 2 < < XX cord-010092-uftc8inx 10406 3 0,01 0,01 NN cord-010092-uftc8inx 10406 4 ) ) -RRB- cord-010092-uftc8inx 10406 5 . . . cord-010092-uftc8inx 10407 1 CD63 cd63 NN cord-010092-uftc8inx 10407 2 + + CC cord-010092-uftc8inx 10407 3 CP CP NNP cord-010092-uftc8inx 10407 4 was be VBD cord-010092-uftc8inx 10407 5 higher high JJR cord-010092-uftc8inx 10407 6 in in IN cord-010092-uftc8inx 10407 7 non non JJ cord-010092-uftc8inx 10407 8 - - JJ cord-010092-uftc8inx 10407 9 bleeding bleeding JJ cord-010092-uftc8inx 10407 10 ( ( -LRB- cord-010092-uftc8inx 10407 11 97,25 97,25 CD cord-010092-uftc8inx 10407 12 % % NN cord-010092-uftc8inx 10407 13 and and CC cord-010092-uftc8inx 10407 14 10,54MFI 10,54mfi CD cord-010092-uftc8inx 10407 15 ) ) -RRB- cord-010092-uftc8inx 10407 16 compared compare VBN cord-010092-uftc8inx 10407 17 to to IN cord-010092-uftc8inx 10407 18 both both DT cord-010092-uftc8inx 10407 19 bleeding bleed VBG cord-010092-uftc8inx 10407 20 patients patient NNS cord-010092-uftc8inx 10407 21 ( ( -LRB- cord-010092-uftc8inx 10407 22 94,88 94,88 CD cord-010092-uftc8inx 10407 23 % % NN cord-010092-uftc8inx 10407 24 and and CC cord-010092-uftc8inx 10407 25 6,89MFI 6,89mfi CD cord-010092-uftc8inx 10407 26 ) ) -RRB- cord-010092-uftc8inx 10407 27 and and CC cord-010092-uftc8inx 10407 28 significantly significantly RB cord-010092-uftc8inx 10407 29 higher high JJR cord-010092-uftc8inx 10407 30 than than IN cord-010092-uftc8inx 10407 31 the the DT cord-010092-uftc8inx 10407 32 reference reference NN cord-010092-uftc8inx 10407 33 level level NN cord-010092-uftc8inx 10407 34 ( ( -LRB- cord-010092-uftc8inx 10407 35 88,44 88,44 CD cord-010092-uftc8inx 10407 36 % % NN cord-010092-uftc8inx 10407 37 and and CC cord-010092-uftc8inx 10407 38 5,36MFI 5,36mfi CD cord-010092-uftc8inx 10407 39 , , , cord-010092-uftc8inx 10407 40 both both DT cord-010092-uftc8inx 10407 41 P p NN cord-010092-uftc8inx 10407 42 < < XX cord-010092-uftc8inx 10407 43 0,05 0,05 NNP cord-010092-uftc8inx 10407 44 ) ) -RRB- cord-010092-uftc8inx 10407 45 . . . cord-010092-uftc8inx 10408 1 Finally finally RB cord-010092-uftc8inx 10408 2 , , , cord-010092-uftc8inx 10408 3 the the DT cord-010092-uftc8inx 10408 4 proportion proportion NN cord-010092-uftc8inx 10408 5 of of IN cord-010092-uftc8inx 10408 6 PS+PMPs PS+PMPs NNP cord-010092-uftc8inx 10408 7 was be VBD cord-010092-uftc8inx 10408 8 normal normal JJ cord-010092-uftc8inx 10408 9 in in IN cord-010092-uftc8inx 10408 10 bleeding bleed VBG cord-010092-uftc8inx 10408 11 patients patient NNS cord-010092-uftc8inx 10408 12 , , , cord-010092-uftc8inx 10408 13 but but CC cord-010092-uftc8inx 10408 14 their -PRON- PRP$ cord-010092-uftc8inx 10408 15 PMPs pmp NNS cord-010092-uftc8inx 10408 16 expressed express VBD cord-010092-uftc8inx 10408 17 higher high JJR cord-010092-uftc8inx 10408 18 than than IN cord-010092-uftc8inx 10408 19 reference reference NN cord-010092-uftc8inx 10408 20 PS ps NN cord-010092-uftc8inx 10408 21 per per IN cord-010092-uftc8inx 10408 22 cell cell NN cord-010092-uftc8inx 10408 23 , , , cord-010092-uftc8inx 10408 24 both both CC cord-010092-uftc8inx 10408 25 unstimulated unstimulated JJ cord-010092-uftc8inx 10408 26 and and CC cord-010092-uftc8inx 10408 27 for for IN cord-010092-uftc8inx 10408 28 all all DT cord-010092-uftc8inx 10408 29 agonist agonist NN cord-010092-uftc8inx 10408 30 ( ( -LRB- cord-010092-uftc8inx 10408 31 134,12 134,12 CD cord-010092-uftc8inx 10408 32 MFI MFI NNP cord-010092-uftc8inx 10408 33 unstimulated unstimulated JJ cord-010092-uftc8inx 10408 34 vs vs IN cord-010092-uftc8inx 10408 35 32,38 32,38 CD cord-010092-uftc8inx 10408 36 MFI MFI NNP cord-010092-uftc8inx 10408 37 reference reference NN cord-010092-uftc8inx 10408 38 , , , cord-010092-uftc8inx 10409 1 P p NN cord-010092-uftc8inx 10409 2 < < XX cord-010092-uftc8inx 10409 3 0,01 0,01 NN cord-010092-uftc8inx 10409 4 ) ) -RRB- cord-010092-uftc8inx 10409 5 . . . cord-010092-uftc8inx 10410 1 Summary Summary NNP cord-010092-uftc8inx 10410 2 / / SYM cord-010092-uftc8inx 10410 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 10410 4 : : : cord-010092-uftc8inx 10411 1 Patients patient NNS cord-010092-uftc8inx 10411 2 with with IN cord-010092-uftc8inx 10411 3 IT it PRP cord-010092-uftc8inx 10411 4 exhibited exhibit VBD cord-010092-uftc8inx 10411 5 different different JJ cord-010092-uftc8inx 10411 6 bleeding bleeding NN cord-010092-uftc8inx 10411 7 tendency tendency NN cord-010092-uftc8inx 10411 8 despite despite IN cord-010092-uftc8inx 10411 9 comparable comparable JJ cord-010092-uftc8inx 10411 10 thrombocytopenia thrombocytopenia NN cord-010092-uftc8inx 10411 11 . . . cord-010092-uftc8inx 10412 1 In in IN cord-010092-uftc8inx 10412 2 non non JJ cord-010092-uftc8inx 10412 3 - - JJ cord-010092-uftc8inx 10412 4 bleeding bleeding JJ cord-010092-uftc8inx 10412 5 patients patient NNS cord-010092-uftc8inx 10412 6 the the DT cord-010092-uftc8inx 10412 7 proportion proportion NN cord-010092-uftc8inx 10412 8 and and CC cord-010092-uftc8inx 10412 9 per per IN cord-010092-uftc8inx 10412 10 cell cell NN cord-010092-uftc8inx 10412 11 level level NN cord-010092-uftc8inx 10412 12 of of IN cord-010092-uftc8inx 10412 13 PS+ PS+ NNP cord-010092-uftc8inx 10412 14 were be VBD cord-010092-uftc8inx 10412 15 higher high JJR cord-010092-uftc8inx 10412 16 , , , cord-010092-uftc8inx 10412 17 indicating indicate VBG cord-010092-uftc8inx 10412 18 that that IN cord-010092-uftc8inx 10412 19 generation generation NN cord-010092-uftc8inx 10412 20 of of IN cord-010092-uftc8inx 10412 21 CPs cp NNS cord-010092-uftc8inx 10412 22 with with IN cord-010092-uftc8inx 10412 23 high high JJ cord-010092-uftc8inx 10412 24 PS PS NNP cord-010092-uftc8inx 10412 25 expression expression NN cord-010092-uftc8inx 10412 26 is be VBZ cord-010092-uftc8inx 10412 27 a a DT cord-010092-uftc8inx 10412 28 critical critical JJ cord-010092-uftc8inx 10412 29 factor factor NN cord-010092-uftc8inx 10412 30 determining determine VBG cord-010092-uftc8inx 10412 31 bleeding bleed VBG cord-010092-uftc8inx 10412 32 phenotype phenotype NN cord-010092-uftc8inx 10412 33 . . . cord-010092-uftc8inx 10413 1 The the DT cord-010092-uftc8inx 10413 2 finding finding NN cord-010092-uftc8inx 10413 3 of of IN cord-010092-uftc8inx 10413 4 high high JJ cord-010092-uftc8inx 10413 5 PMP PMP NNP cord-010092-uftc8inx 10413 6 PS PS NNP cord-010092-uftc8inx 10413 7 per per IN cord-010092-uftc8inx 10413 8 cell cell NN cord-010092-uftc8inx 10413 9 level level NN cord-010092-uftc8inx 10413 10 in in IN cord-010092-uftc8inx 10413 11 bleeding bleed VBG cord-010092-uftc8inx 10413 12 patients patient NNS cord-010092-uftc8inx 10413 13 could could MD cord-010092-uftc8inx 10413 14 represent represent VB cord-010092-uftc8inx 10413 15 an an DT cord-010092-uftc8inx 10413 16 inadequate inadequate JJ cord-010092-uftc8inx 10413 17 compensation compensation NN cord-010092-uftc8inx 10413 18 for for IN cord-010092-uftc8inx 10413 19 lack lack NN cord-010092-uftc8inx 10413 20 of of IN cord-010092-uftc8inx 10413 21 CP cp NN cord-010092-uftc8inx 10413 22 function function NN cord-010092-uftc8inx 10413 23 , , , cord-010092-uftc8inx 10413 24 indicating indicate VBG cord-010092-uftc8inx 10413 25 that that IN cord-010092-uftc8inx 10413 26 procoagulant procoagulant NN cord-010092-uftc8inx 10413 27 PMPs pmp NNS cord-010092-uftc8inx 10413 28 may may MD cord-010092-uftc8inx 10413 29 be be VB cord-010092-uftc8inx 10413 30 less less RBR cord-010092-uftc8inx 10413 31 important important JJ cord-010092-uftc8inx 10413 32 than than IN cord-010092-uftc8inx 10413 33 CPs cp NNS cord-010092-uftc8inx 10413 34 for for IN cord-010092-uftc8inx 10413 35 thrombocytopenic thrombocytopenic JJ cord-010092-uftc8inx 10413 36 bleeding bleeding NN cord-010092-uftc8inx 10413 37 . . . cord-010092-uftc8inx 10414 1 Quantification quantification NN cord-010092-uftc8inx 10414 2 and and CC cord-010092-uftc8inx 10414 3 characterization characterization NN cord-010092-uftc8inx 10414 4 of of IN cord-010092-uftc8inx 10414 5 CPs cp NNS cord-010092-uftc8inx 10414 6 may may MD cord-010092-uftc8inx 10414 7 be be VB cord-010092-uftc8inx 10414 8 a a DT cord-010092-uftc8inx 10414 9 useful useful JJ cord-010092-uftc8inx 10414 10 tool tool NN cord-010092-uftc8inx 10414 11 for for IN cord-010092-uftc8inx 10414 12 future future JJ cord-010092-uftc8inx 10414 13 assessment assessment NN cord-010092-uftc8inx 10414 14 of of IN cord-010092-uftc8inx 10414 15 bleeding bleed VBG cord-010092-uftc8inx 10414 16 risk risk NN cord-010092-uftc8inx 10414 17 as as RB cord-010092-uftc8inx 10414 18 well well RB cord-010092-uftc8inx 10414 19 as as IN cord-010092-uftc8inx 10414 20 a a DT cord-010092-uftc8inx 10414 21 therapeutic therapeutic JJ cord-010092-uftc8inx 10414 22 target target NN cord-010092-uftc8inx 10414 23 in in IN cord-010092-uftc8inx 10414 24 IT IT NNP cord-010092-uftc8inx 10414 25 and and CC cord-010092-uftc8inx 10414 26 other other JJ cord-010092-uftc8inx 10414 27 conditions condition NNS cord-010092-uftc8inx 10414 28 with with IN cord-010092-uftc8inx 10414 29 bleeding bleed VBG cord-010092-uftc8inx 10414 30 diathesis diathesis NN cord-010092-uftc8inx 10414 31 and/or and/or CC cord-010092-uftc8inx 10414 32 thrombocytopenia thrombocytopenia NN cord-010092-uftc8inx 10414 33 . . . cord-010092-uftc8inx 10415 1 More More JJR cord-010092-uftc8inx 10415 2 studies study NNS cord-010092-uftc8inx 10415 3 investigating investigate VBG cord-010092-uftc8inx 10415 4 this this DT cord-010092-uftc8inx 10415 5 field field NN cord-010092-uftc8inx 10415 6 are be VBP cord-010092-uftc8inx 10415 7 warranted warrant VBN cord-010092-uftc8inx 10415 8 . . . cord-010092-uftc8inx 10416 1 Background background NN cord-010092-uftc8inx 10416 2 : : : cord-010092-uftc8inx 10417 1 Alloantibodies Alloantibodies NNP cord-010092-uftc8inx 10417 2 against against IN cord-010092-uftc8inx 10417 3 human human JJ cord-010092-uftc8inx 10417 4 platelet platelet NN cord-010092-uftc8inx 10417 5 antigens antigen NNS cord-010092-uftc8inx 10417 6 ( ( -LRB- cord-010092-uftc8inx 10417 7 HPAs HPAs NNP cord-010092-uftc8inx 10417 8 ) ) -RRB- cord-010092-uftc8inx 10417 9 and and CC cord-010092-uftc8inx 10417 10 human human JJ cord-010092-uftc8inx 10417 11 leukocyte leukocyte NN cord-010092-uftc8inx 10417 12 antigen antigen NN cord-010092-uftc8inx 10417 13 ( ( -LRB- cord-010092-uftc8inx 10417 14 HLA HLA NNP cord-010092-uftc8inx 10417 15 ) ) -RRB- cord-010092-uftc8inx 10417 16 are be VBP cord-010092-uftc8inx 10417 17 implicated implicate VBN cord-010092-uftc8inx 10417 18 in in IN cord-010092-uftc8inx 10417 19 several several JJ cord-010092-uftc8inx 10417 20 immune immune NN cord-010092-uftc8inx 10417 21 - - HYPH cord-010092-uftc8inx 10417 22 mediated mediate VBN cord-010092-uftc8inx 10417 23 platelet platelet NN cord-010092-uftc8inx 10417 24 disorders disorder NNS cord-010092-uftc8inx 10417 25 . . . cord-010092-uftc8inx 10418 1 Detection detection NN cord-010092-uftc8inx 10418 2 of of IN cord-010092-uftc8inx 10418 3 these these DT cord-010092-uftc8inx 10418 4 antibodies antibody NNS cord-010092-uftc8inx 10418 5 is be VBZ cord-010092-uftc8inx 10418 6 crucial crucial JJ cord-010092-uftc8inx 10418 7 in in IN cord-010092-uftc8inx 10418 8 the the DT cord-010092-uftc8inx 10418 9 diagnosis diagnosis NN cord-010092-uftc8inx 10418 10 and and CC cord-010092-uftc8inx 10418 11 management management NN cord-010092-uftc8inx 10418 12 of of IN cord-010092-uftc8inx 10418 13 these these DT cord-010092-uftc8inx 10418 14 disorders disorder NNS cord-010092-uftc8inx 10418 15 . . . cord-010092-uftc8inx 10419 1 Aims aim VBZ cord-010092-uftc8inx 10419 2 : : : cord-010092-uftc8inx 10420 1 To to TO cord-010092-uftc8inx 10420 2 establish establish VB cord-010092-uftc8inx 10420 3 a a DT cord-010092-uftc8inx 10420 4 method method NN cord-010092-uftc8inx 10420 5 detecting detect VBG cord-010092-uftc8inx 10420 6 HPA-1 HPA-1 NNP cord-010092-uftc8inx 10420 7 , , , cord-010092-uftc8inx 10420 8 HPA-2 HPA-2 NNP cord-010092-uftc8inx 10420 9 , , , cord-010092-uftc8inx 10420 10 HPA-3 HPA-3 NNP cord-010092-uftc8inx 10420 11 , , , cord-010092-uftc8inx 10420 12 HPA-5 HPA-5 NNP cord-010092-uftc8inx 10420 13 and and CC cord-010092-uftc8inx 10420 14 HLA HLA NNP cord-010092-uftc8inx 10420 15 antibodies antibody NNS cord-010092-uftc8inx 10420 16 using use VBG cord-010092-uftc8inx 10420 17 Luminex Luminex NNP cord-010092-uftc8inx 10420 18 bead bead NN cord-010092-uftc8inx 10420 19 technology technology NN cord-010092-uftc8inx 10420 20 . . . cord-010092-uftc8inx 10421 1 Methods method NNS cord-010092-uftc8inx 10421 2 : : : cord-010092-uftc8inx 10421 3 Monoclonal monoclonal JJ cord-010092-uftc8inx 10421 4 antibodies antibody NNS cord-010092-uftc8inx 10421 5 specific specific JJ cord-010092-uftc8inx 10421 6 for for IN cord-010092-uftc8inx 10421 7 platelet platelet NN cord-010092-uftc8inx 10421 8 glycoproteins glycoprotein NNS cord-010092-uftc8inx 10421 9 and and CC cord-010092-uftc8inx 10421 10 HLA HLA NNP cord-010092-uftc8inx 10421 11 class class NN cord-010092-uftc8inx 10422 1 I -PRON- PRP cord-010092-uftc8inx 10422 2 molecules molecule NNS cord-010092-uftc8inx 10422 3 were be VBD cord-010092-uftc8inx 10422 4 separately separately RB cord-010092-uftc8inx 10422 5 coupled couple VBN cord-010092-uftc8inx 10422 6 to to IN cord-010092-uftc8inx 10422 7 the the DT cord-010092-uftc8inx 10422 8 Luminex Luminex NNP cord-010092-uftc8inx 10422 9 microbeads microbead NNS cord-010092-uftc8inx 10422 10 . . . cord-010092-uftc8inx 10423 1 Positive positive JJ cord-010092-uftc8inx 10423 2 anti anti JJ cord-010092-uftc8inx 10423 3 - - NN cord-010092-uftc8inx 10423 4 HPA-1a HPA-1a NNP cord-010092-uftc8inx 10424 1 , , , cord-010092-uftc8inx 10424 2 anti anti JJ cord-010092-uftc8inx 10424 3 - - NNP cord-010092-uftc8inx 10424 4 HPA-2b hpa-2b JJ cord-010092-uftc8inx 10424 5 , , , cord-010092-uftc8inx 10424 6 anti anti JJ cord-010092-uftc8inx 10424 7 - - NNP cord-010092-uftc8inx 10424 8 HPA-3a hpa-3a JJ cord-010092-uftc8inx 10424 9 , , , cord-010092-uftc8inx 10424 10 anti anti JJ cord-010092-uftc8inx 10424 11 - - JJ cord-010092-uftc8inx 10424 12 HPA-5a hpa-5a JJ cord-010092-uftc8inx 10424 13 samples sample NNS cord-010092-uftc8inx 10424 14 were be VBD cord-010092-uftc8inx 10424 15 used use VBN cord-010092-uftc8inx 10424 16 to to TO cord-010092-uftc8inx 10424 17 validate validate VB cord-010092-uftc8inx 10424 18 the the DT cord-010092-uftc8inx 10424 19 specificities specificity NNS cord-010092-uftc8inx 10424 20 of of IN cord-010092-uftc8inx 10424 21 the the DT cord-010092-uftc8inx 10424 22 Luminex Luminex NNP cord-010092-uftc8inx 10424 23 assay assay NN cord-010092-uftc8inx 10424 24 . . . cord-010092-uftc8inx 10425 1 The the DT cord-010092-uftc8inx 10425 2 anti anti JJ cord-010092-uftc8inx 10425 3 - - NNP cord-010092-uftc8inx 10425 4 HPA-1a HPA-1a NNP cord-010092-uftc8inx 10425 5 , , , cord-010092-uftc8inx 10425 6 anti anti JJ cord-010092-uftc8inx 10425 7 - - JJ cord-010092-uftc8inx 10425 8 HPA-3a hpa-3a JJ cord-010092-uftc8inx 10425 9 standard standard JJ cord-010092-uftc8inx 10425 10 samples sample NNS cord-010092-uftc8inx 10425 11 were be VBD cord-010092-uftc8inx 10425 12 used use VBN cord-010092-uftc8inx 10425 13 to to TO cord-010092-uftc8inx 10425 14 evaluate evaluate VB cord-010092-uftc8inx 10425 15 the the DT cord-010092-uftc8inx 10425 16 sensitivities sensitivity NNS cord-010092-uftc8inx 10425 17 of of IN cord-010092-uftc8inx 10425 18 the the DT cord-010092-uftc8inx 10425 19 Luminex Luminex NNP cord-010092-uftc8inx 10425 20 assay assay NN cord-010092-uftc8inx 10425 21 by by IN cord-010092-uftc8inx 10425 22 serial serial JJ cord-010092-uftc8inx 10425 23 dilutions dilution NNS cord-010092-uftc8inx 10425 24 ( ( -LRB- cord-010092-uftc8inx 10425 25 from from IN cord-010092-uftc8inx 10425 26 neat neat JJ cord-010092-uftc8inx 10425 27 to to IN cord-010092-uftc8inx 10425 28 1/1024 1/1024 NN cord-010092-uftc8inx 10425 29 ) ) -RRB- cord-010092-uftc8inx 10425 30 . . . cord-010092-uftc8inx 10426 1 Results result NNS cord-010092-uftc8inx 10426 2 : : : cord-010092-uftc8inx 10427 1 44 44 CD cord-010092-uftc8inx 10427 2 samples sample NNS cord-010092-uftc8inx 10427 3 collected collect VBN cord-010092-uftc8inx 10427 4 from from IN cord-010092-uftc8inx 10427 5 patients patient NNS cord-010092-uftc8inx 10427 6 or or CC cord-010092-uftc8inx 10427 7 ISBT ISBT NNP cord-010092-uftc8inx 10427 8 platelet platelet NN cord-010092-uftc8inx 10427 9 workshop workshop NN cord-010092-uftc8inx 10427 10 were be VBD cord-010092-uftc8inx 10427 11 tested test VBN cord-010092-uftc8inx 10427 12 by by IN cord-010092-uftc8inx 10427 13 the the DT cord-010092-uftc8inx 10427 14 Luminex Luminex NNP cord-010092-uftc8inx 10427 15 assay assay NN cord-010092-uftc8inx 10427 16 . . . cord-010092-uftc8inx 10428 1 The the DT cord-010092-uftc8inx 10428 2 results result NNS cord-010092-uftc8inx 10428 3 showed show VBD cord-010092-uftc8inx 10428 4 that that IN cord-010092-uftc8inx 10428 5 Luminex Luminex NNP cord-010092-uftc8inx 10428 6 assay assay NN cord-010092-uftc8inx 10428 7 could could MD cord-010092-uftc8inx 10428 8 detect detect VB cord-010092-uftc8inx 10428 9 antibodies antibody NNS cord-010092-uftc8inx 10428 10 against against IN cord-010092-uftc8inx 10428 11 HPA-1a HPA-1a NNP cord-010092-uftc8inx 10428 12 , , , cord-010092-uftc8inx 10428 13 HPA-2b HPA-2b NNP cord-010092-uftc8inx 10428 14 , , , cord-010092-uftc8inx 10428 15 HPA-3a HPA-3a NNP cord-010092-uftc8inx 10428 16 , , , cord-010092-uftc8inx 10428 17 or or CC cord-010092-uftc8inx 10428 18 HPA-5a HPA-5a NNP cord-010092-uftc8inx 10428 19 successfully successfully RB cord-010092-uftc8inx 10428 20 from from IN cord-010092-uftc8inx 10428 21 the the DT cord-010092-uftc8inx 10428 22 known know VBN cord-010092-uftc8inx 10428 23 samples sample NNS cord-010092-uftc8inx 10428 24 . . . cord-010092-uftc8inx 10429 1 The the DT cord-010092-uftc8inx 10429 2 sensitivities sensitivity NNS cord-010092-uftc8inx 10429 3 of of IN cord-010092-uftc8inx 10429 4 the the DT cord-010092-uftc8inx 10429 5 Luminex Luminex NNP cord-010092-uftc8inx 10429 6 assay assay NN cord-010092-uftc8inx 10429 7 detecting detect VBG cord-010092-uftc8inx 10429 8 anti anti NNP cord-010092-uftc8inx 10429 9 - - NNP cord-010092-uftc8inx 10429 10 HPA-1a HPA-1a NNP cord-010092-uftc8inx 10429 11 , , , cord-010092-uftc8inx 10429 12 and and CC cord-010092-uftc8inx 10429 13 anti anti JJ cord-010092-uftc8inx 10429 14 - - NNP cord-010092-uftc8inx 10429 15 HPA-3a HPA-3a NNP cord-010092-uftc8inx 10429 16 were be VBD cord-010092-uftc8inx 10429 17 1:512 1:512 CD cord-010092-uftc8inx 10429 18 and and CC cord-010092-uftc8inx 10429 19 1:64 1:64 CD cord-010092-uftc8inx 10429 20 , , , cord-010092-uftc8inx 10429 21 respectively respectively RB cord-010092-uftc8inx 10429 22 , , , cord-010092-uftc8inx 10429 23 using use VBG cord-010092-uftc8inx 10429 24 the the DT cord-010092-uftc8inx 10429 25 standard standard JJ cord-010092-uftc8inx 10429 26 samples sample NNS cord-010092-uftc8inx 10429 27 . . . cord-010092-uftc8inx 10430 1 No no DT cord-010092-uftc8inx 10430 2 cross cross NN cord-010092-uftc8inx 10430 3 - - NN cord-010092-uftc8inx 10430 4 reactivity reactivity NN cord-010092-uftc8inx 10430 5 was be VBD cord-010092-uftc8inx 10430 6 observed observe VBN cord-010092-uftc8inx 10430 7 in in IN cord-010092-uftc8inx 10430 8 the the DT cord-010092-uftc8inx 10430 9 samples sample NNS cord-010092-uftc8inx 10430 10 containing contain VBG cord-010092-uftc8inx 10430 11 multi multi JJ cord-010092-uftc8inx 10430 12 - - JJ cord-010092-uftc8inx 10430 13 platelet platelet JJ cord-010092-uftc8inx 10430 14 antibodies antibody NNS cord-010092-uftc8inx 10430 15 , , , cord-010092-uftc8inx 10430 16 or or CC cord-010092-uftc8inx 10430 17 mixture mixture NN cord-010092-uftc8inx 10430 18 antibodies antibody NNS cord-010092-uftc8inx 10430 19 against against IN cord-010092-uftc8inx 10430 20 HPA HPA NNP cord-010092-uftc8inx 10430 21 and and CC cord-010092-uftc8inx 10430 22 HLA HLA NNP cord-010092-uftc8inx 10430 23 . . . cord-010092-uftc8inx 10431 1 The the DT cord-010092-uftc8inx 10431 2 results result NNS cord-010092-uftc8inx 10431 3 of of IN cord-010092-uftc8inx 10431 4 44 44 CD cord-010092-uftc8inx 10431 5 samples sample NNS cord-010092-uftc8inx 10431 6 with with IN cord-010092-uftc8inx 10431 7 platelet platelet NN cord-010092-uftc8inx 10431 8 disorders disorder NNS cord-010092-uftc8inx 10431 9 were be VBD cord-010092-uftc8inx 10431 10 agreement agreement NN cord-010092-uftc8inx 10431 11 with with IN cord-010092-uftc8inx 10431 12 those those DT cord-010092-uftc8inx 10431 13 of of IN cord-010092-uftc8inx 10431 14 monoclonal monoclonal JJ cord-010092-uftc8inx 10431 15 antibody antibody NN cord-010092-uftc8inx 10431 16 immobilization immobilization NN cord-010092-uftc8inx 10431 17 of of IN cord-010092-uftc8inx 10431 18 platelet platelet NN cord-010092-uftc8inx 10431 19 antigens antigen NNS cord-010092-uftc8inx 10431 20 ( ( -LRB- cord-010092-uftc8inx 10431 21 MAIPA MAIPA NNP cord-010092-uftc8inx 10431 22 ) ) -RRB- cord-010092-uftc8inx 10431 23 assay assay NN cord-010092-uftc8inx 10431 24 . . . cord-010092-uftc8inx 10432 1 Summary Summary NNP cord-010092-uftc8inx 10432 2 / / SYM cord-010092-uftc8inx 10432 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 10432 4 : : : cord-010092-uftc8inx 10433 1 Luminex Luminex NNP cord-010092-uftc8inx 10433 2 beads bead NNS cord-010092-uftc8inx 10433 3 coupled couple VBN cord-010092-uftc8inx 10433 4 with with IN cord-010092-uftc8inx 10433 5 monoclonal monoclonal JJ cord-010092-uftc8inx 10433 6 antibodies antibody NNS cord-010092-uftc8inx 10433 7 could could MD cord-010092-uftc8inx 10433 8 be be VB cord-010092-uftc8inx 10433 9 successfully successfully RB cord-010092-uftc8inx 10433 10 used use VBN cord-010092-uftc8inx 10433 11 to to TO cord-010092-uftc8inx 10433 12 detect detect VB cord-010092-uftc8inx 10433 13 HPA HPA NNP cord-010092-uftc8inx 10433 14 and and CC cord-010092-uftc8inx 10433 15 HLA HLA NNP cord-010092-uftc8inx 10433 16 antibodies antibody NNS cord-010092-uftc8inx 10433 17 with with IN cord-010092-uftc8inx 10433 18 high high JJ cord-010092-uftc8inx 10433 19 sensitivity sensitivity NN cord-010092-uftc8inx 10433 20 . . . cord-010092-uftc8inx 10434 1 Background background NN cord-010092-uftc8inx 10434 2 : : : cord-010092-uftc8inx 10435 1 Platelet platelet NN cord-010092-uftc8inx 10435 2 transfusion transfusion NN cord-010092-uftc8inx 10435 3 is be VBZ cord-010092-uftc8inx 10435 4 important important JJ cord-010092-uftc8inx 10435 5 in in IN cord-010092-uftc8inx 10435 6 clinical clinical JJ cord-010092-uftc8inx 10435 7 treatment treatment NN cord-010092-uftc8inx 10435 8 . . . cord-010092-uftc8inx 10436 1 The the DT cord-010092-uftc8inx 10436 2 expression expression NN cord-010092-uftc8inx 10436 3 of of IN cord-010092-uftc8inx 10436 4 ABO ABO NNP cord-010092-uftc8inx 10436 5 antigen antigen NN cord-010092-uftc8inx 10436 6 on on IN cord-010092-uftc8inx 10436 7 platelet platelet NN cord-010092-uftc8inx 10436 8 surface surface NN cord-010092-uftc8inx 10436 9 is be VBZ cord-010092-uftc8inx 10436 10 differential differential JJ cord-010092-uftc8inx 10436 11 , , , cord-010092-uftc8inx 10436 12 so so CC cord-010092-uftc8inx 10436 13 it -PRON- PRP cord-010092-uftc8inx 10436 14 is be VBZ cord-010092-uftc8inx 10436 15 usually usually RB cord-010092-uftc8inx 10436 16 need need VBP cord-010092-uftc8inx 10436 17 to to TO cord-010092-uftc8inx 10436 18 ensure ensure VB cord-010092-uftc8inx 10436 19 the the DT cord-010092-uftc8inx 10436 20 consistency consistency NN cord-010092-uftc8inx 10436 21 of of IN cord-010092-uftc8inx 10436 22 the the DT cord-010092-uftc8inx 10436 23 ABO ABO NNP cord-010092-uftc8inx 10436 24 antigen antigen NN cord-010092-uftc8inx 10436 25 in in IN cord-010092-uftc8inx 10436 26 clinical clinical JJ cord-010092-uftc8inx 10436 27 transfusion transfusion NN cord-010092-uftc8inx 10436 28 . . . cord-010092-uftc8inx 10437 1 But but CC cord-010092-uftc8inx 10437 2 in in IN cord-010092-uftc8inx 10437 3 many many JJ cord-010092-uftc8inx 10437 4 cases case NNS cord-010092-uftc8inx 10437 5 , , , cord-010092-uftc8inx 10437 6 it -PRON- PRP cord-010092-uftc8inx 10437 7 is be VBZ cord-010092-uftc8inx 10437 8 difficult difficult JJ cord-010092-uftc8inx 10437 9 to to TO cord-010092-uftc8inx 10437 10 find find VB cord-010092-uftc8inx 10437 11 the the DT cord-010092-uftc8inx 10437 12 platelets platelet NNS cord-010092-uftc8inx 10437 13 that that IN cord-010092-uftc8inx 10437 14 the the DT cord-010092-uftc8inx 10437 15 ABO ABO NNP cord-010092-uftc8inx 10437 16 blood blood NN cord-010092-uftc8inx 10437 17 type type NN cord-010092-uftc8inx 10437 18 matched match VBN cord-010092-uftc8inx 10437 19 between between IN cord-010092-uftc8inx 10437 20 the the DT cord-010092-uftc8inx 10437 21 recipient recipient NN cord-010092-uftc8inx 10437 22 and and CC cord-010092-uftc8inx 10437 23 donor donor NN cord-010092-uftc8inx 10437 24 , , , cord-010092-uftc8inx 10437 25 and and CC cord-010092-uftc8inx 10437 26 ABO ABO NNP cord-010092-uftc8inx 10437 27 - - HYPH cord-010092-uftc8inx 10437 28 incompatible incompatible JJ cord-010092-uftc8inx 10437 29 platelet platelet NN cord-010092-uftc8inx 10437 30 infusion infusion NN cord-010092-uftc8inx 10437 31 is be VBZ cord-010092-uftc8inx 10437 32 required require VBN cord-010092-uftc8inx 10437 33 in in IN cord-010092-uftc8inx 10437 34 these these DT cord-010092-uftc8inx 10437 35 cases case NNS cord-010092-uftc8inx 10437 36 . . . cord-010092-uftc8inx 10438 1 To to IN cord-010092-uftc8inx 10438 2 data datum NNS cord-010092-uftc8inx 10438 3 , , , cord-010092-uftc8inx 10438 4 the the DT cord-010092-uftc8inx 10438 5 expression expression NN cord-010092-uftc8inx 10438 6 of of IN cord-010092-uftc8inx 10438 7 ABO ABO NNP cord-010092-uftc8inx 10438 8 antigens antigen NNS cord-010092-uftc8inx 10438 9 on on IN cord-010092-uftc8inx 10438 10 platelets platelet NNS cord-010092-uftc8inx 10438 11 in in IN cord-010092-uftc8inx 10438 12 normal normal JJ cord-010092-uftc8inx 10438 13 blood blood NN cord-010092-uftc8inx 10438 14 group group NN cord-010092-uftc8inx 10438 15 individuals individual NNS cord-010092-uftc8inx 10438 16 is be VBZ cord-010092-uftc8inx 10438 17 rarely rarely RB cord-010092-uftc8inx 10438 18 reported report VBN cord-010092-uftc8inx 10438 19 in in IN cord-010092-uftc8inx 10438 20 Chinese chinese JJ cord-010092-uftc8inx 10438 21 population population NN cord-010092-uftc8inx 10438 22 . . . cord-010092-uftc8inx 10439 1 Aims aim VBZ cord-010092-uftc8inx 10439 2 : : : cord-010092-uftc8inx 10440 1 To to TO cord-010092-uftc8inx 10440 2 understand understand VB cord-010092-uftc8inx 10440 3 the the DT cord-010092-uftc8inx 10440 4 differential differential JJ cord-010092-uftc8inx 10440 5 expression expression NN cord-010092-uftc8inx 10440 6 of of IN cord-010092-uftc8inx 10440 7 ABO ABO NNP cord-010092-uftc8inx 10440 8 antigen antigen NN cord-010092-uftc8inx 10440 9 on on IN cord-010092-uftc8inx 10440 10 platelet platelet NN cord-010092-uftc8inx 10440 11 surface surface NN cord-010092-uftc8inx 10440 12 in in IN cord-010092-uftc8inx 10440 13 population population NN cord-010092-uftc8inx 10440 14 of of IN cord-010092-uftc8inx 10440 15 Zhejiang Zhejiang NNP cord-010092-uftc8inx 10440 16 province province NN cord-010092-uftc8inx 10440 17 , , , cord-010092-uftc8inx 10440 18 China China NNP cord-010092-uftc8inx 10440 19 . . . cord-010092-uftc8inx 10441 1 Methods method NNS cord-010092-uftc8inx 10441 2 : : : cord-010092-uftc8inx 10441 3 Total total NN cord-010092-uftc8inx 10441 4 of of IN cord-010092-uftc8inx 10441 5 358 358 CD cord-010092-uftc8inx 10441 6 individuals individual NNS cord-010092-uftc8inx 10441 7 with with IN cord-010092-uftc8inx 10441 8 normal normal JJ cord-010092-uftc8inx 10441 9 ABO ABO NNP cord-010092-uftc8inx 10441 10 groups group NNS cord-010092-uftc8inx 10441 11 ( ( -LRB- cord-010092-uftc8inx 10441 12 101 101 CD cord-010092-uftc8inx 10441 13 group group NN cord-010092-uftc8inx 10441 14 A A NNP cord-010092-uftc8inx 10441 15 , , , cord-010092-uftc8inx 10441 16 100 100 CD cord-010092-uftc8inx 10441 17 group group NN cord-010092-uftc8inx 10441 18 B b NN cord-010092-uftc8inx 10441 19 and and CC cord-010092-uftc8inx 10441 20 101 101 CD cord-010092-uftc8inx 10441 21 group group NN cord-010092-uftc8inx 10441 22 AB AB NNP cord-010092-uftc8inx 10441 23 individuals individual NNS cord-010092-uftc8inx 10441 24 , , , cord-010092-uftc8inx 10441 25 and and CC cord-010092-uftc8inx 10441 26 56 56 CD cord-010092-uftc8inx 10441 27 group group NN cord-010092-uftc8inx 10441 28 O o NN cord-010092-uftc8inx 10441 29 as as IN cord-010092-uftc8inx 10441 30 negative negative JJ cord-010092-uftc8inx 10441 31 control control NN cord-010092-uftc8inx 10441 32 of of IN cord-010092-uftc8inx 10441 33 ABO ABO NNP cord-010092-uftc8inx 10441 34 antigens antigen NNS cord-010092-uftc8inx 10441 35 on on IN cord-010092-uftc8inx 10441 36 platelets platelet NNS cord-010092-uftc8inx 10441 37 ) ) -RRB- cord-010092-uftc8inx 10441 38 were be VBD cord-010092-uftc8inx 10441 39 analyzed analyze VBN cord-010092-uftc8inx 10441 40 . . . cord-010092-uftc8inx 10442 1 The the DT cord-010092-uftc8inx 10442 2 expression expression NN cord-010092-uftc8inx 10442 3 of of IN cord-010092-uftc8inx 10442 4 ABO ABO NNP cord-010092-uftc8inx 10442 5 antigens antigen NNS cord-010092-uftc8inx 10442 6 on on IN cord-010092-uftc8inx 10442 7 platelets platelet NNS cord-010092-uftc8inx 10442 8 was be VBD cord-010092-uftc8inx 10442 9 determined determine VBN cord-010092-uftc8inx 10442 10 by by IN cord-010092-uftc8inx 10442 11 flow flow NN cord-010092-uftc8inx 10442 12 cytometry cytometry NN cord-010092-uftc8inx 10442 13 using use VBG cord-010092-uftc8inx 10442 14 monoclonal monoclonal JJ cord-010092-uftc8inx 10442 15 antibodies antibody NNS cord-010092-uftc8inx 10442 16 : : : cord-010092-uftc8inx 10442 17 Fluorescein Fluorescein NNP cord-010092-uftc8inx 10442 18 isothiocyanate isothiocyanate NN cord-010092-uftc8inx 10442 19 ( ( -LRB- cord-010092-uftc8inx 10442 20 FITC)-conjugated fitc)-conjugate VBN cord-010092-uftc8inx 10442 21 mouse mouse NN cord-010092-uftc8inx 10442 22 antihuman antihuman JJ cord-010092-uftc8inx 10442 23 blood blood NN cord-010092-uftc8inx 10442 24 group group NN cord-010092-uftc8inx 10442 25 A A NNP cord-010092-uftc8inx 10442 26 and and CC cord-010092-uftc8inx 10442 27 PE pe NN cord-010092-uftc8inx 10442 28 - - HYPH cord-010092-uftc8inx 10442 29 conjugated conjugate VBN cord-010092-uftc8inx 10442 30 murine murine JJ cord-010092-uftc8inx 10442 31 IgG1 igg1 XX cord-010092-uftc8inx 10442 32 anti anti NN cord-010092-uftc8inx 10442 33 - - JJ cord-010092-uftc8inx 10442 34 B b JJ cord-010092-uftc8inx 10442 35 antibody antibody NN cord-010092-uftc8inx 10442 36 ( ( -LRB- cord-010092-uftc8inx 10442 37 9431PE 9431pe CD cord-010092-uftc8inx 10442 38 BGRL1 BGRL1 NNS cord-010092-uftc8inx 10442 39 ) ) -RRB- cord-010092-uftc8inx 10442 40 . . . cord-010092-uftc8inx 10443 1 Flow flow VB cord-010092-uftc8inx 10443 2 cytometric cytometric NN cord-010092-uftc8inx 10443 3 parameters parameter NNS cord-010092-uftc8inx 10443 4 were be VBD cord-010092-uftc8inx 10443 5 statistically statistically RB cord-010092-uftc8inx 10443 6 analyzed analyze VBN cord-010092-uftc8inx 10443 7 by by IN cord-010092-uftc8inx 10443 8 the the DT cord-010092-uftc8inx 10443 9 Mann Mann NNP cord-010092-uftc8inx 10443 10 - - HYPH cord-010092-uftc8inx 10443 11 Whitney Whitney NNP cord-010092-uftc8inx 10443 12 test test NN cord-010092-uftc8inx 10443 13 or or CC cord-010092-uftc8inx 10443 14 the the DT cord-010092-uftc8inx 10443 15 Kruskal Kruskal NNP cord-010092-uftc8inx 10443 16 - - HYPH cord-010092-uftc8inx 10443 17 Wallis Wallis NNP cord-010092-uftc8inx 10443 18 test test NN cord-010092-uftc8inx 10443 19 to to TO cord-010092-uftc8inx 10443 20 observe observe VB cord-010092-uftc8inx 10443 21 the the DT cord-010092-uftc8inx 10443 22 difference difference NN cord-010092-uftc8inx 10443 23 in in IN cord-010092-uftc8inx 10443 24 two two CD cord-010092-uftc8inx 10443 25 or or CC cord-010092-uftc8inx 10443 26 more more JJR cord-010092-uftc8inx 10443 27 groups group NNS cord-010092-uftc8inx 10443 28 using use VBG cord-010092-uftc8inx 10443 29 GraphPad GraphPad NNP cord-010092-uftc8inx 10443 30 software software NN cord-010092-uftc8inx 10443 31 v5.01 v5.01 NN cord-010092-uftc8inx 10443 32 . . . cord-010092-uftc8inx 10444 1 The the DT cord-010092-uftc8inx 10444 2 correlation correlation NN cord-010092-uftc8inx 10444 3 and and CC cord-010092-uftc8inx 10444 4 regression regression NN cord-010092-uftc8inx 10444 5 analysis analysis NN cord-010092-uftc8inx 10444 6 between between IN cord-010092-uftc8inx 10444 7 A a NN cord-010092-uftc8inx 10444 8 and and CC cord-010092-uftc8inx 10444 9 B b NN cord-010092-uftc8inx 10444 10 antigen antigen NN cord-010092-uftc8inx 10444 11 in in IN cord-010092-uftc8inx 10444 12 the the DT cord-010092-uftc8inx 10444 13 platelets platelet NNS cord-010092-uftc8inx 10444 14 and and CC cord-010092-uftc8inx 10444 15 RBCs rbc NNS cord-010092-uftc8inx 10444 16 were be VBD cord-010092-uftc8inx 10444 17 also also RB cord-010092-uftc8inx 10444 18 performed perform VBN cord-010092-uftc8inx 10444 19 by by IN cord-010092-uftc8inx 10444 20 the the DT cord-010092-uftc8inx 10444 21 software software NN cord-010092-uftc8inx 10444 22 . . . cord-010092-uftc8inx 10445 1 Population population NN cord-010092-uftc8inx 10445 2 studies study NNS cord-010092-uftc8inx 10445 3 were be VBD cord-010092-uftc8inx 10445 4 reported report VBN cord-010092-uftc8inx 10445 5 as as IN cord-010092-uftc8inx 10445 6 the the DT cord-010092-uftc8inx 10445 7 mean mean JJ cord-010092-uftc8inx 10445 8 and and CC cord-010092-uftc8inx 10445 9 standard standard JJ cord-010092-uftc8inx 10445 10 deviation deviation NN cord-010092-uftc8inx 10445 11 ( ( -LRB- cord-010092-uftc8inx 10445 12 SD SD NNP cord-010092-uftc8inx 10445 13 ) ) -RRB- cord-010092-uftc8inx 10445 14 , , , cord-010092-uftc8inx 10445 15 and and CC cord-010092-uftc8inx 10445 16 P p NN cord-010092-uftc8inx 10445 17 values value NNS cord-010092-uftc8inx 10445 18 less less JJR cord-010092-uftc8inx 10445 19 than than IN cord-010092-uftc8inx 10445 20 0.05 0.05 CD cord-010092-uftc8inx 10445 21 were be VBD cord-010092-uftc8inx 10445 22 considered consider VBN cord-010092-uftc8inx 10445 23 statistically statistically RB cord-010092-uftc8inx 10445 24 significant significant JJ cord-010092-uftc8inx 10445 25 . . . cord-010092-uftc8inx 10446 1 Results result NNS cord-010092-uftc8inx 10446 2 : : : cord-010092-uftc8inx 10447 1 According accord VBG cord-010092-uftc8inx 10447 2 to to IN cord-010092-uftc8inx 10447 3 MFI MFI NNP cord-010092-uftc8inx 10447 4 values value NNS cord-010092-uftc8inx 10447 5 of of IN cord-010092-uftc8inx 10447 6 ABO ABO NNP cord-010092-uftc8inx 10447 7 antigens antigen NNS cord-010092-uftc8inx 10447 8 expression expression NN cord-010092-uftc8inx 10447 9 on on IN cord-010092-uftc8inx 10447 10 platelets platelet NNS cord-010092-uftc8inx 10447 11 , , , cord-010092-uftc8inx 10447 12 the the DT cord-010092-uftc8inx 10447 13 samples sample NNS cord-010092-uftc8inx 10447 14 were be VBD cord-010092-uftc8inx 10447 15 divided divide VBN cord-010092-uftc8inx 10447 16 into into IN cord-010092-uftc8inx 10447 17 three three CD cord-010092-uftc8inx 10447 18 groups group NNS cord-010092-uftc8inx 10447 19 : : : cord-010092-uftc8inx 10447 20 low low JJ cord-010092-uftc8inx 10447 21 expression expression NN cord-010092-uftc8inx 10447 22 ( ( -LRB- cord-010092-uftc8inx 10447 23 LE LE NNP cord-010092-uftc8inx 10447 24 ) ) -RRB- cord-010092-uftc8inx 10447 25 , , , cord-010092-uftc8inx 10447 26 high high JJ cord-010092-uftc8inx 10447 27 expression(HE expression(HE NNS cord-010092-uftc8inx 10447 28 ) ) -RRB- cord-010092-uftc8inx 10447 29 and and CC cord-010092-uftc8inx 10447 30 moderate moderate JJ cord-010092-uftc8inx 10447 31 expression expression NN cord-010092-uftc8inx 10447 32 ( ( -LRB- cord-010092-uftc8inx 10447 33 ME ME NNP cord-010092-uftc8inx 10447 34 ) ) -RRB- cord-010092-uftc8inx 10447 35 according accord VBG cord-010092-uftc8inx 10447 36 to to IN cord-010092-uftc8inx 10447 37 the the DT cord-010092-uftc8inx 10447 38 background background NN cord-010092-uftc8inx 10447 39 MFI MFI NNP cord-010092-uftc8inx 10447 40 observed observe VBD cord-010092-uftc8inx 10447 41 in in IN cord-010092-uftc8inx 10447 42 group group NN cord-010092-uftc8inx 10447 43 O o NN cord-010092-uftc8inx 10447 44 samples sample NNS cord-010092-uftc8inx 10447 45 . . . cord-010092-uftc8inx 10448 1 It -PRON- PRP cord-010092-uftc8inx 10448 2 was be VBD cord-010092-uftc8inx 10448 3 found find VBN cord-010092-uftc8inx 10448 4 that that IN cord-010092-uftc8inx 10448 5 about about IN cord-010092-uftc8inx 10448 6 66.22 66.22 CD cord-010092-uftc8inx 10448 7 % % NN cord-010092-uftc8inx 10448 8 of of IN cord-010092-uftc8inx 10448 9 the the DT cord-010092-uftc8inx 10448 10 individuals individual NNS cord-010092-uftc8inx 10448 11 had have VBD cord-010092-uftc8inx 10448 12 a a DT cord-010092-uftc8inx 10448 13 weak weak JJ cord-010092-uftc8inx 10448 14 expression expression NN cord-010092-uftc8inx 10448 15 of of IN cord-010092-uftc8inx 10448 16 ABO ABO NNP cord-010092-uftc8inx 10448 17 antigen antigen NN cord-010092-uftc8inx 10448 18 on on IN cord-010092-uftc8inx 10448 19 the the DT cord-010092-uftc8inx 10448 20 platelet platelet NN cord-010092-uftc8inx 10448 21 surface surface NN cord-010092-uftc8inx 10448 22 in in IN cord-010092-uftc8inx 10448 23 Zhejiang Zhejiang NNP cord-010092-uftc8inx 10448 24 province province NN cord-010092-uftc8inx 10448 25 . . . cord-010092-uftc8inx 10449 1 there there EX cord-010092-uftc8inx 10449 2 was be VBD cord-010092-uftc8inx 10449 3 a a DT cord-010092-uftc8inx 10449 4 significant significant JJ cord-010092-uftc8inx 10449 5 difference difference NN cord-010092-uftc8inx 10449 6 in in IN cord-010092-uftc8inx 10449 7 the the DT cord-010092-uftc8inx 10449 8 intensity intensity NN cord-010092-uftc8inx 10449 9 of of IN cord-010092-uftc8inx 10449 10 antigen antigen NN cord-010092-uftc8inx 10449 11 expression expression NN cord-010092-uftc8inx 10449 12 between between IN cord-010092-uftc8inx 10449 13 these these DT cord-010092-uftc8inx 10449 14 three three CD cord-010092-uftc8inx 10449 15 different different JJ cord-010092-uftc8inx 10449 16 groups group NNS cord-010092-uftc8inx 10449 17 of of IN cord-010092-uftc8inx 10449 18 the the DT cord-010092-uftc8inx 10449 19 same same JJ cord-010092-uftc8inx 10449 20 blood blood NN cord-010092-uftc8inx 10449 21 group group NN cord-010092-uftc8inx 10449 22 . . . cord-010092-uftc8inx 10450 1 For for IN cord-010092-uftc8inx 10450 2 each each DT cord-010092-uftc8inx 10450 3 blood blood NN cord-010092-uftc8inx 10450 4 group group NN cord-010092-uftc8inx 10450 5 , , , cord-010092-uftc8inx 10450 6 there there EX cord-010092-uftc8inx 10450 7 was be VBD cord-010092-uftc8inx 10450 8 a a DT cord-010092-uftc8inx 10450 9 positive positive JJ cord-010092-uftc8inx 10450 10 correlation correlation NN cord-010092-uftc8inx 10450 11 between between IN cord-010092-uftc8inx 10450 12 the the DT cord-010092-uftc8inx 10450 13 intensity intensity NN cord-010092-uftc8inx 10450 14 of of IN cord-010092-uftc8inx 10450 15 ABO ABO NNP cord-010092-uftc8inx 10450 16 antigen antigen NN cord-010092-uftc8inx 10450 17 expressed express VBD cord-010092-uftc8inx 10450 18 on on IN cord-010092-uftc8inx 10450 19 the the DT cord-010092-uftc8inx 10450 20 platelet platelet NN cord-010092-uftc8inx 10450 21 membrane membrane NN cord-010092-uftc8inx 10450 22 and and CC cord-010092-uftc8inx 10450 23 red red JJ cord-010092-uftc8inx 10450 24 blood blood NN cord-010092-uftc8inx 10450 25 cells cell NNS cord-010092-uftc8inx 10450 26 of of IN cord-010092-uftc8inx 10450 27 the the DT cord-010092-uftc8inx 10450 28 individuals individual NNS cord-010092-uftc8inx 10450 29 . . . cord-010092-uftc8inx 10451 1 Results result NNS cord-010092-uftc8inx 10451 2 : : : cord-010092-uftc8inx 10451 3 40 40 CD cord-010092-uftc8inx 10451 4 cases case NNS cord-010092-uftc8inx 10451 5 were be VBD cord-010092-uftc8inx 10451 6 found find VBN cord-010092-uftc8inx 10451 7 with with IN cord-010092-uftc8inx 10451 8 antibody antibody NN cord-010092-uftc8inx 10451 9 positive positive JJ cord-010092-uftc8inx 10451 10 . . . cord-010092-uftc8inx 10452 1 Among among IN cord-010092-uftc8inx 10452 2 them -PRON- PRP cord-010092-uftc8inx 10452 3 , , , cord-010092-uftc8inx 10452 4 6 6 CD cord-010092-uftc8inx 10452 5 cases case NNS cord-010092-uftc8inx 10452 6 ( ( -LRB- cord-010092-uftc8inx 10452 7 15 15 CD cord-010092-uftc8inx 10452 8 % % NN cord-010092-uftc8inx 10452 9 ) ) -RRB- cord-010092-uftc8inx 10452 10 were be VBD cord-010092-uftc8inx 10452 11 only only RB cord-010092-uftc8inx 10452 12 anti anti JJ cord-010092-uftc8inx 10452 13 - - JJ cord-010092-uftc8inx 10452 14 HLA HLA NNP cord-010092-uftc8inx 10452 15 - - HYPH cord-010092-uftc8inx 10452 16 I -PRON- PRP cord-010092-uftc8inx 10452 17 positive positive JJ cord-010092-uftc8inx 10452 18 , , , cord-010092-uftc8inx 10452 19 4 4 CD cord-010092-uftc8inx 10452 20 cases case NNS cord-010092-uftc8inx 10452 21 ( ( -LRB- cord-010092-uftc8inx 10452 22 10 10 CD cord-010092-uftc8inx 10452 23 % % NN cord-010092-uftc8inx 10452 24 ) ) -RRB- cord-010092-uftc8inx 10452 25 were be VBD cord-010092-uftc8inx 10452 26 only only RB cord-010092-uftc8inx 10452 27 anti anti JJ cord-010092-uftc8inx 10452 28 - - JJ cord-010092-uftc8inx 10452 29 HPA hpa JJ cord-010092-uftc8inx 10452 30 positive positive JJ cord-010092-uftc8inx 10452 31 , , , cord-010092-uftc8inx 10452 32 30 30 CD cord-010092-uftc8inx 10452 33 cases case NNS cord-010092-uftc8inx 10452 34 ( ( -LRB- cord-010092-uftc8inx 10452 35 75 75 CD cord-010092-uftc8inx 10452 36 % % NN cord-010092-uftc8inx 10452 37 ) ) -RRB- cord-010092-uftc8inx 10452 38 were be VBD cord-010092-uftc8inx 10452 39 both both DT cord-010092-uftc8inx 10452 40 anti anti JJ cord-010092-uftc8inx 10452 41 - - JJ cord-010092-uftc8inx 10452 42 HLA HLA NNP cord-010092-uftc8inx 10452 43 - - HYPH cord-010092-uftc8inx 10452 44 I I NNP cord-010092-uftc8inx 10452 45 and and CC cord-010092-uftc8inx 10452 46 anti anti JJ cord-010092-uftc8inx 10452 47 - - JJ cord-010092-uftc8inx 10452 48 HPA hpa JJ cord-010092-uftc8inx 10452 49 positive positive JJ cord-010092-uftc8inx 10452 50 . . . cord-010092-uftc8inx 10453 1 8 8 CD cord-010092-uftc8inx 10453 2 cases case NNS cord-010092-uftc8inx 10453 3 were be VBD cord-010092-uftc8inx 10453 4 found find VBN cord-010092-uftc8inx 10453 5 without without IN cord-010092-uftc8inx 10453 6 anti anti JJ cord-010092-uftc8inx 10453 7 - - JJ cord-010092-uftc8inx 10453 8 HLA HLA NNP cord-010092-uftc8inx 10453 9 - - HYPH cord-010092-uftc8inx 10453 10 I i NN cord-010092-uftc8inx 10453 11 or or CC cord-010092-uftc8inx 10453 12 anti anti JJ cord-010092-uftc8inx 10453 13 - - JJ cord-010092-uftc8inx 10453 14 HPA HPA NNP cord-010092-uftc8inx 10453 15 . . . cord-010092-uftc8inx 10454 1 Among among IN cord-010092-uftc8inx 10454 2 the the DT cord-010092-uftc8inx 10454 3 34 34 CD cord-010092-uftc8inx 10454 4 cases case NNS cord-010092-uftc8inx 10454 5 with with IN cord-010092-uftc8inx 10454 6 anti anti JJ cord-010092-uftc8inx 10454 7 - - JJ cord-010092-uftc8inx 10454 8 HPA hpa JJ cord-010092-uftc8inx 10454 9 positive positive JJ cord-010092-uftc8inx 10454 10 , , , cord-010092-uftc8inx 10454 11 the the DT cord-010092-uftc8inx 10454 12 distributions distribution NNS cord-010092-uftc8inx 10454 13 of of IN cord-010092-uftc8inx 10454 14 anti anti JJ cord-010092-uftc8inx 10454 15 - - JJ cord-010092-uftc8inx 10454 16 GPIIb GPIIb NNS cord-010092-uftc8inx 10454 17 / / SYM cord-010092-uftc8inx 10454 18 IIIa iiia NN cord-010092-uftc8inx 10454 19 , , , cord-010092-uftc8inx 10454 20 anti anti JJ cord-010092-uftc8inx 10454 21 - - NNP cord-010092-uftc8inx 10454 22 GPIa GPIa NNPS cord-010092-uftc8inx 10454 23 / / SYM cord-010092-uftc8inx 10454 24 IIa IIa NNP cord-010092-uftc8inx 10454 25 , , , cord-010092-uftc8inx 10454 26 anti anti JJ cord-010092-uftc8inx 10454 27 - - NNP cord-010092-uftc8inx 10454 28 GPIb gpib JJ cord-010092-uftc8inx 10454 29 / / SYM cord-010092-uftc8inx 10454 30 IX IX NNP cord-010092-uftc8inx 10454 31 , , , cord-010092-uftc8inx 10454 32 anti anti JJ cord-010092-uftc8inx 10454 33 - - NNP cord-010092-uftc8inx 10454 34 GPIV GPIV NNP cord-010092-uftc8inx 10454 35 were be VBD cord-010092-uftc8inx 10454 36 73.5 73.5 CD cord-010092-uftc8inx 10454 37 % % NN cord-010092-uftc8inx 10454 38 , , , cord-010092-uftc8inx 10454 39 61.2 61.2 CD cord-010092-uftc8inx 10454 40 % % NN cord-010092-uftc8inx 10454 41 , , , cord-010092-uftc8inx 10454 42 50 50 CD cord-010092-uftc8inx 10454 43 % % NN cord-010092-uftc8inx 10454 44 , , , cord-010092-uftc8inx 10454 45 44.1 44.1 CD cord-010092-uftc8inx 10454 46 % % NN cord-010092-uftc8inx 10454 47 , , , cord-010092-uftc8inx 10454 48 respectively respectively RB cord-010092-uftc8inx 10454 49 . . . cord-010092-uftc8inx 10455 1 , , , cord-010092-uftc8inx 10455 2 HLA HLA NNP cord-010092-uftc8inx 10455 3 antibody antibody NN cord-010092-uftc8inx 10455 4 positive positive JJ cord-010092-uftc8inx 10455 5 rate rate NN cord-010092-uftc8inx 10455 6 in in IN cord-010092-uftc8inx 10455 7 the the DT cord-010092-uftc8inx 10455 8 female female JJ cord-010092-uftc8inx 10455 9 patients patient NNS cord-010092-uftc8inx 10455 10 was be VBD cord-010092-uftc8inx 10455 11 higher high JJR cord-010092-uftc8inx 10455 12 than than IN cord-010092-uftc8inx 10455 13 that that DT cord-010092-uftc8inx 10455 14 in in IN cord-010092-uftc8inx 10455 15 the the DT cord-010092-uftc8inx 10455 16 male male NN cord-010092-uftc8inx 10455 17 and and CC cord-010092-uftc8inx 10455 18 HPA HPA NNP cord-010092-uftc8inx 10455 19 antibody antibody NN cord-010092-uftc8inx 10455 20 positive positive JJ cord-010092-uftc8inx 10455 21 rate rate NN cord-010092-uftc8inx 10455 22 in in IN cord-010092-uftc8inx 10455 23 the the DT cord-010092-uftc8inx 10455 24 female female NN cord-010092-uftc8inx 10455 25 was be VBD cord-010092-uftc8inx 10455 26 lower low JJR cord-010092-uftc8inx 10455 27 than than IN cord-010092-uftc8inx 10455 28 that that DT cord-010092-uftc8inx 10455 29 in in IN cord-010092-uftc8inx 10455 30 male male NN cord-010092-uftc8inx 10455 31 , , , cord-010092-uftc8inx 10455 32 but but CC cord-010092-uftc8inx 10455 33 there there EX cord-010092-uftc8inx 10455 34 was be VBD cord-010092-uftc8inx 10455 35 no no DT cord-010092-uftc8inx 10455 36 significance significance NN cord-010092-uftc8inx 10455 37 difference difference NN cord-010092-uftc8inx 10455 38 between between IN cord-010092-uftc8inx 10455 39 them -PRON- PRP cord-010092-uftc8inx 10455 40 ( ( -LRB- cord-010092-uftc8inx 10455 41 P p NN cord-010092-uftc8inx 10455 42 > > XX cord-010092-uftc8inx 10455 43 0.05 0.05 CD cord-010092-uftc8inx 10455 44 ) ) -RRB- cord-010092-uftc8inx 10455 45 . . . cord-010092-uftc8inx 10456 1 Summary Summary NNP cord-010092-uftc8inx 10456 2 / / SYM cord-010092-uftc8inx 10456 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 10456 4 : : : cord-010092-uftc8inx 10457 1 In in IN cord-010092-uftc8inx 10457 2 PTR ptr NN cord-010092-uftc8inx 10457 3 patients patient NNS cord-010092-uftc8inx 10457 4 , , , cord-010092-uftc8inx 10457 5 the the DT cord-010092-uftc8inx 10457 6 platelet platelet NN cord-010092-uftc8inx 10457 7 antibody antibody NN cord-010092-uftc8inx 10457 8 was be VBD cord-010092-uftc8inx 10457 9 mainly mainly RB cord-010092-uftc8inx 10457 10 HLA HLA NNP cord-010092-uftc8inx 10457 11 - - HYPH cord-010092-uftc8inx 10457 12 I i NN cord-010092-uftc8inx 10457 13 antibody antibody NN cord-010092-uftc8inx 10457 14 combined combine VBN cord-010092-uftc8inx 10457 15 with with IN cord-010092-uftc8inx 10457 16 HPA HPA NNP cord-010092-uftc8inx 10457 17 antibody antibody NN cord-010092-uftc8inx 10457 18 . . . cord-010092-uftc8inx 10458 1 Background background NN cord-010092-uftc8inx 10458 2 : : : cord-010092-uftc8inx 10459 1 Human human JJ cord-010092-uftc8inx 10459 2 neutrophil neutrophil NN cord-010092-uftc8inx 10459 3 antigens antigen NNS cord-010092-uftc8inx 10459 4 ( ( -LRB- cord-010092-uftc8inx 10459 5 HNA HNA NNP cord-010092-uftc8inx 10459 6 ) ) -RRB- cord-010092-uftc8inx 10459 7 are be VBP cord-010092-uftc8inx 10459 8 polymorphic polymorphic JJ cord-010092-uftc8inx 10459 9 structures structure NNS cord-010092-uftc8inx 10459 10 located locate VBN cord-010092-uftc8inx 10459 11 on on IN cord-010092-uftc8inx 10459 12 surface surface NN cord-010092-uftc8inx 10459 13 membrane membrane NN cord-010092-uftc8inx 10459 14 of of IN cord-010092-uftc8inx 10459 15 human human JJ cord-010092-uftc8inx 10459 16 neutrophils neutrophil NNS cord-010092-uftc8inx 10459 17 . . . cord-010092-uftc8inx 10460 1 Alloantibodies Alloantibodies NNP cord-010092-uftc8inx 10460 2 against against IN cord-010092-uftc8inx 10460 3 HNA HNA NNP cord-010092-uftc8inx 10460 4 are be VBP cord-010092-uftc8inx 10460 5 implicated implicate VBN cord-010092-uftc8inx 10460 6 in in IN cord-010092-uftc8inx 10460 7 a a DT cord-010092-uftc8inx 10460 8 number number NN cord-010092-uftc8inx 10460 9 of of IN cord-010092-uftc8inx 10460 10 clinical clinical JJ cord-010092-uftc8inx 10460 11 conditions condition NNS cord-010092-uftc8inx 10460 12 , , , cord-010092-uftc8inx 10460 13 including include VBG cord-010092-uftc8inx 10460 14 immune immune NN cord-010092-uftc8inx 10460 15 - - HYPH cord-010092-uftc8inx 10460 16 mediated mediate VBN cord-010092-uftc8inx 10460 17 neutropenia neutropenia NN cord-010092-uftc8inx 10460 18 and and CC cord-010092-uftc8inx 10460 19 transfusion transfusion NN cord-010092-uftc8inx 10460 20 reactions reaction NNS cord-010092-uftc8inx 10460 21 . . . cord-010092-uftc8inx 10461 1 Genotyping genotype VBG cord-010092-uftc8inx 10461 2 for for IN cord-010092-uftc8inx 10461 3 human human JJ cord-010092-uftc8inx 10461 4 neutrophil neutrophil NN cord-010092-uftc8inx 10461 5 antigen antigen NN cord-010092-uftc8inx 10461 6 ( ( -LRB- cord-010092-uftc8inx 10461 7 HNA HNA NNP cord-010092-uftc8inx 10461 8 ) ) -RRB- cord-010092-uftc8inx 10461 9 systems system NNS cord-010092-uftc8inx 10461 10 is be VBZ cord-010092-uftc8inx 10461 11 an an DT cord-010092-uftc8inx 10461 12 important important JJ cord-010092-uftc8inx 10461 13 in in IN cord-010092-uftc8inx 10461 14 the the DT cord-010092-uftc8inx 10461 15 diagnosis diagnosis NN cord-010092-uftc8inx 10461 16 of of IN cord-010092-uftc8inx 10461 17 disorders disorder NNS cord-010092-uftc8inx 10461 18 involving involve VBG cord-010092-uftc8inx 10461 19 alloimmunization alloimmunization NN cord-010092-uftc8inx 10461 20 to to IN cord-010092-uftc8inx 10461 21 HNA HNA NNP cord-010092-uftc8inx 10461 22 . . . cord-010092-uftc8inx 10462 1 Aims aim VBZ cord-010092-uftc8inx 10462 2 : : : cord-010092-uftc8inx 10463 1 The the DT cord-010092-uftc8inx 10463 2 aim aim NN cord-010092-uftc8inx 10463 3 of of IN cord-010092-uftc8inx 10463 4 this this DT cord-010092-uftc8inx 10463 5 study study NN cord-010092-uftc8inx 10463 6 was be VBD cord-010092-uftc8inx 10463 7 to to TO cord-010092-uftc8inx 10463 8 investigate investigate VB cord-010092-uftc8inx 10463 9 the the DT cord-010092-uftc8inx 10463 10 HNA HNA NNP cord-010092-uftc8inx 10463 11 allele allele NN cord-010092-uftc8inx 10463 12 frequencies frequency NNS cord-010092-uftc8inx 10463 13 among among IN cord-010092-uftc8inx 10463 14 blood blood NN cord-010092-uftc8inx 10463 15 donors donor NNS cord-010092-uftc8inx 10463 16 and and CC cord-010092-uftc8inx 10463 17 hematological hematological JJ cord-010092-uftc8inx 10463 18 patients patient NNS cord-010092-uftc8inx 10463 19 undergoing undergo VBG cord-010092-uftc8inx 10463 20 blood blood NN cord-010092-uftc8inx 10463 21 transfusions transfusion NNS cord-010092-uftc8inx 10463 22 and and CC cord-010092-uftc8inx 10463 23 to to TO cord-010092-uftc8inx 10463 24 estimate estimate VB cord-010092-uftc8inx 10463 25 possible possible JJ cord-010092-uftc8inx 10463 26 HNA HNA NNP cord-010092-uftc8inx 10463 27 incompatibilities incompatibility NNS cord-010092-uftc8inx 10463 28 and and CC cord-010092-uftc8inx 10463 29 risk risk NN cord-010092-uftc8inx 10463 30 of of IN cord-010092-uftc8inx 10463 31 HNA HNA NNP cord-010092-uftc8inx 10463 32 alloimmunization alloimmunization NN cord-010092-uftc8inx 10463 33 . . . cord-010092-uftc8inx 10464 1 Methods method NNS cord-010092-uftc8inx 10464 2 : : : cord-010092-uftc8inx 10464 3 A a DT cord-010092-uftc8inx 10464 4 total total NN cord-010092-uftc8inx 10464 5 of of IN cord-010092-uftc8inx 10464 6 303 303 CD cord-010092-uftc8inx 10464 7 blood blood NN cord-010092-uftc8inx 10464 8 donors donor NNS cord-010092-uftc8inx 10464 9 and and CC cord-010092-uftc8inx 10464 10 302 302 CD cord-010092-uftc8inx 10464 11 hematological hematological JJ cord-010092-uftc8inx 10464 12 patients patient NNS cord-010092-uftc8inx 10464 13 from from IN cord-010092-uftc8inx 10464 14 the the DT cord-010092-uftc8inx 10464 15 North North NNP cord-010092-uftc8inx 10464 16 - - HYPH cord-010092-uftc8inx 10464 17 West West NNP cord-010092-uftc8inx 10464 18 region region NN cord-010092-uftc8inx 10464 19 of of IN cord-010092-uftc8inx 10464 20 the the DT cord-010092-uftc8inx 10464 21 Russian Russian NNP cord-010092-uftc8inx 10464 22 Federation Federation NNP cord-010092-uftc8inx 10464 23 were be VBD cord-010092-uftc8inx 10464 24 recruited recruit VBN cord-010092-uftc8inx 10464 25 . . . cord-010092-uftc8inx 10465 1 DNA dna NN cord-010092-uftc8inx 10465 2 samples sample NNS cord-010092-uftc8inx 10465 3 were be VBD cord-010092-uftc8inx 10465 4 obtained obtain VBN cord-010092-uftc8inx 10465 5 and and CC cord-010092-uftc8inx 10465 6 typed type VBN cord-010092-uftc8inx 10465 7 for for IN cord-010092-uftc8inx 10465 8 HNA-1 HNA-1 NNP cord-010092-uftc8inx 10465 9 , , , cord-010092-uftc8inx 10465 10 -3 -3 NNP cord-010092-uftc8inx 10465 11 , , , cord-010092-uftc8inx 10465 12 -4 -4 NNP cord-010092-uftc8inx 10465 13 and and CC cord-010092-uftc8inx 10465 14 -5 -5 NNP cord-010092-uftc8inx 10465 15 systems system NNS cord-010092-uftc8inx 10465 16 using use VBG cord-010092-uftc8inx 10465 17 polymerase polymerase NN cord-010092-uftc8inx 10465 18 chain chain NN cord-010092-uftc8inx 10465 19 reactions reaction NNS cord-010092-uftc8inx 10465 20 with with IN cord-010092-uftc8inx 10465 21 sequence sequence NN cord-010092-uftc8inx 10465 22 - - HYPH cord-010092-uftc8inx 10465 23 specific specific JJ cord-010092-uftc8inx 10465 24 primers primer NNS cord-010092-uftc8inx 10465 25 ( ( -LRB- cord-010092-uftc8inx 10465 26 PCR PCR NNP cord-010092-uftc8inx 10465 27 - - HYPH cord-010092-uftc8inx 10465 28 SSP SSP NNP cord-010092-uftc8inx 10465 29 ) ) -RRB- cord-010092-uftc8inx 10465 30 . . . cord-010092-uftc8inx 10466 1 Specific specific JJ cord-010092-uftc8inx 10466 2 primers primer NNS cord-010092-uftc8inx 10466 3 for for IN cord-010092-uftc8inx 10466 4 HNA HNA NNP cord-010092-uftc8inx 10466 5 were be VBD cord-010092-uftc8inx 10466 6 designed design VBN cord-010092-uftc8inx 10466 7 and and CC cord-010092-uftc8inx 10466 8 the the DT cord-010092-uftc8inx 10466 9 polymerase polymerase NN cord-010092-uftc8inx 10466 10 chain chain NN cord-010092-uftc8inx 10466 11 reaction reaction NN cord-010092-uftc8inx 10466 12 amplification amplification NN cord-010092-uftc8inx 10466 13 conditions condition NNS cord-010092-uftc8inx 10466 14 were be VBD cord-010092-uftc8inx 10466 15 optimized optimize VBN cord-010092-uftc8inx 10466 16 . . . cord-010092-uftc8inx 10467 1 The the DT cord-010092-uftc8inx 10467 2 v v NN cord-010092-uftc8inx 10467 3 2 2 CD cord-010092-uftc8inx 10467 4 test test NN cord-010092-uftc8inx 10467 5 was be VBD cord-010092-uftc8inx 10467 6 used use VBN cord-010092-uftc8inx 10467 7 to to TO cord-010092-uftc8inx 10467 8 test test VB cord-010092-uftc8inx 10467 9 for for IN cord-010092-uftc8inx 10467 10 the the DT cord-010092-uftc8inx 10467 11 Hardy Hardy NNP cord-010092-uftc8inx 10467 12 - - HYPH cord-010092-uftc8inx 10467 13 Weinberg Weinberg NNP cord-010092-uftc8inx 10467 14 equilibrium equilibrium NN cord-010092-uftc8inx 10467 15 for for IN cord-010092-uftc8inx 10467 16 the the DT cord-010092-uftc8inx 10467 17 HNA HNA NNP cord-010092-uftc8inx 10467 18 systems system NNS cord-010092-uftc8inx 10467 19 . . . cord-010092-uftc8inx 10468 1 The the DT cord-010092-uftc8inx 10468 2 probabilities probability NNS cord-010092-uftc8inx 10468 3 of of IN cord-010092-uftc8inx 10468 4 the the DT cord-010092-uftc8inx 10468 5 incompatibility incompatibility NN cord-010092-uftc8inx 10468 6 and and CC cord-010092-uftc8inx 10468 7 the the DT cord-010092-uftc8inx 10468 8 potential potential JJ cord-010092-uftc8inx 10468 9 risk risk NN cord-010092-uftc8inx 10468 10 for for IN cord-010092-uftc8inx 10468 11 alloimmunization alloimmunization NN cord-010092-uftc8inx 10468 12 against against IN cord-010092-uftc8inx 10468 13 different different JJ cord-010092-uftc8inx 10468 14 HNA HNA NNP cord-010092-uftc8inx 10468 15 systems system NNS cord-010092-uftc8inx 10468 16 after after IN cord-010092-uftc8inx 10468 17 random random JJ cord-010092-uftc8inx 10468 18 transfusions transfusion NNS cord-010092-uftc8inx 10468 19 were be VBD cord-010092-uftc8inx 10468 20 estimated estimate VBN cord-010092-uftc8inx 10468 21 based base VBN cord-010092-uftc8inx 10468 22 on on IN cord-010092-uftc8inx 10468 23 the the DT cord-010092-uftc8inx 10468 24 HNA HNA NNP cord-010092-uftc8inx 10468 25 allele allele NN cord-010092-uftc8inx 10468 26 and and CC cord-010092-uftc8inx 10468 27 genotype genotype NN cord-010092-uftc8inx 10468 28 frequencies frequency NNS cord-010092-uftc8inx 10468 29 . . . cord-010092-uftc8inx 10469 1 Results result NNS cord-010092-uftc8inx 10469 2 : : : cord-010092-uftc8inx 10470 1 In in IN cord-010092-uftc8inx 10470 2 blood blood NN cord-010092-uftc8inx 10470 3 donors donor NNS cord-010092-uftc8inx 10470 4 , , , cord-010092-uftc8inx 10470 5 the the DT cord-010092-uftc8inx 10470 6 frequencies frequency NNS cord-010092-uftc8inx 10470 7 for for IN cord-010092-uftc8inx 10470 8 the the DT cord-010092-uftc8inx 10470 9 FCGR3B*01 FCGR3B*01 NNP cord-010092-uftc8inx 10470 10 ( ( -LRB- cord-010092-uftc8inx 10470 11 HNA-1a HNA-1a NNP cord-010092-uftc8inx 10470 12 ) ) -RRB- cord-010092-uftc8inx 10470 13 , , , cord-010092-uftc8inx 10470 14 FCGR3B*02 FCGR3B*02 NNP cord-010092-uftc8inx 10470 15 ( ( -LRB- cord-010092-uftc8inx 10470 16 HNA-1bd HNA-1bd NNP cord-010092-uftc8inx 10470 17 ) ) -RRB- cord-010092-uftc8inx 10470 18 , , , cord-010092-uftc8inx 10470 19 and and CC cord-010092-uftc8inx 10470 20 FCGR3B*03 fcgr3b*03 CD cord-010092-uftc8inx 10471 1 ( ( -LRB- cord-010092-uftc8inx 10471 2 HNA-1bc HNA-1bc NNP cord-010092-uftc8inx 10471 3 ) ) -RRB- cord-010092-uftc8inx 10471 4 alleles allele NNS cord-010092-uftc8inx 10471 5 were be VBD cord-010092-uftc8inx 10471 6 0.384 0.384 CD cord-010092-uftc8inx 10471 7 , , , cord-010092-uftc8inx 10471 8 0.584 0.584 CD cord-010092-uftc8inx 10471 9 and and CC cord-010092-uftc8inx 10471 10 0.032 0.032 CD cord-010092-uftc8inx 10471 11 ; ; : cord-010092-uftc8inx 10471 12 for for IN cord-010092-uftc8inx 10471 13 the the DT cord-010092-uftc8inx 10471 14 SLC44A2 SLC44A2 NNP cord-010092-uftc8inx 10471 15 * * NFP cord-010092-uftc8inx 10471 16 1 1 CD cord-010092-uftc8inx 10471 17 ( ( -LRB- cord-010092-uftc8inx 10471 18 HNA-3a HNA-3a NNP cord-010092-uftc8inx 10471 19 ) ) -RRB- cord-010092-uftc8inx 10471 20 and and CC cord-010092-uftc8inx 10471 21 SLC44A2 slc44a2 JJ cord-010092-uftc8inx 10471 22 * * NFP cord-010092-uftc8inx 10471 23 2 2 CD cord-010092-uftc8inx 10471 24 ( ( -LRB- cord-010092-uftc8inx 10471 25 HNA-3b HNA-3b NNP cord-010092-uftc8inx 10471 26 ) ) -RRB- cord-010092-uftc8inx 10471 27 alleles allele NNS cord-010092-uftc8inx 10471 28 , , , cord-010092-uftc8inx 10471 29 0.804 0.804 CD cord-010092-uftc8inx 10471 30 and and CC cord-010092-uftc8inx 10471 31 0.196 0.196 CD cord-010092-uftc8inx 10471 32 ; ; : cord-010092-uftc8inx 10471 33 for for IN cord-010092-uftc8inx 10471 34 the the DT cord-010092-uftc8inx 10471 35 ITGAM*1 ITGAM*1 NNP cord-010092-uftc8inx 10471 36 ( ( -LRB- cord-010092-uftc8inx 10471 37 HNA-4a HNA-4a NNP cord-010092-uftc8inx 10471 38 ) ) -RRB- cord-010092-uftc8inx 10471 39 and and CC cord-010092-uftc8inx 10471 40 ITGAM*2(HNA-4b ITGAM*2(HNA-4b NNP cord-010092-uftc8inx 10471 41 ) ) -RRB- cord-010092-uftc8inx 10471 42 alleles allele NNS cord-010092-uftc8inx 10471 43 , , , cord-010092-uftc8inx 10471 44 0.898 0.898 CD cord-010092-uftc8inx 10471 45 and and CC cord-010092-uftc8inx 10471 46 0.102 0.102 CD cord-010092-uftc8inx 10471 47 ; ; : cord-010092-uftc8inx 10471 48 for for IN cord-010092-uftc8inx 10471 49 the the DT cord-010092-uftc8inx 10471 50 ITGAL*1 itgal*1 NN cord-010092-uftc8inx 10471 51 ( ( -LRB- cord-010092-uftc8inx 10471 52 HNA-5a HNA-5a NNP cord-010092-uftc8inx 10471 53 ) ) -RRB- cord-010092-uftc8inx 10471 54 and and CC cord-010092-uftc8inx 10471 55 ITGAL*2 ITGAL*2 NNP cord-010092-uftc8inx 10471 56 ( ( -LRB- cord-010092-uftc8inx 10471 57 HNA-5b HNA-5b NNP cord-010092-uftc8inx 10471 58 ) ) -RRB- cord-010092-uftc8inx 10471 59 alleles allele NNS cord-010092-uftc8inx 10471 60 , , , cord-010092-uftc8inx 10471 61 0.708 0.708 CD cord-010092-uftc8inx 10471 62 and and CC cord-010092-uftc8inx 10471 63 0.292 0.292 CD cord-010092-uftc8inx 10471 64 , , , cord-010092-uftc8inx 10471 65 respectively respectively RB cord-010092-uftc8inx 10471 66 . . . cord-010092-uftc8inx 10472 1 In in IN cord-010092-uftc8inx 10472 2 hematological hematological JJ cord-010092-uftc8inx 10472 3 patients patient NNS cord-010092-uftc8inx 10472 4 , , , cord-010092-uftc8inx 10472 5 the the DT cord-010092-uftc8inx 10472 6 gene gene NN cord-010092-uftc8inx 10472 7 frequencies frequency NNS cord-010092-uftc8inx 10472 8 for for IN cord-010092-uftc8inx 10472 9 HNA-1a/1bd HNA-1a/1bd NNP cord-010092-uftc8inx 10472 10 / / SYM cord-010092-uftc8inx 10472 11 bc bc NNP cord-010092-uftc8inx 10472 12 , , , cord-010092-uftc8inx 10472 13 -3a/3b -3a/3b NNP cord-010092-uftc8inx 10472 14 , , , cord-010092-uftc8inx 10472 15 -4a/4b -4a/4b ADD cord-010092-uftc8inx 10472 16 , , , cord-010092-uftc8inx 10472 17 and and CC cord-010092-uftc8inx 10472 18 -5a/5b -5a/5b CD cord-010092-uftc8inx 10472 19 were be VBD cord-010092-uftc8inx 10472 20 0.376/0.588/0.036 0.376/0.588/0.036 CD cord-010092-uftc8inx 10472 21 , , , cord-010092-uftc8inx 10472 22 0.795/0.205 0.795/0.205 NN cord-010092-uftc8inx 10472 23 , , , cord-010092-uftc8inx 10472 24 0.887/0.113 0.887/0.113 NNP cord-010092-uftc8inx 10472 25 , , , cord-010092-uftc8inx 10472 26 and and CC cord-010092-uftc8inx 10472 27 0.699/0.301 0.699/0.301 NN cord-010092-uftc8inx 10472 28 , , , cord-010092-uftc8inx 10472 29 respectively respectively RB cord-010092-uftc8inx 10472 30 . . . cord-010092-uftc8inx 10473 1 No no DT cord-010092-uftc8inx 10473 2 statistic statistic JJ cord-010092-uftc8inx 10473 3 significant significant JJ cord-010092-uftc8inx 10473 4 difference difference NN cord-010092-uftc8inx 10473 5 between between IN cord-010092-uftc8inx 10473 6 genotypes genotype NNS cord-010092-uftc8inx 10473 7 in in IN cord-010092-uftc8inx 10473 8 these these DT cord-010092-uftc8inx 10473 9 groups group NNS cord-010092-uftc8inx 10473 10 was be VBD cord-010092-uftc8inx 10473 11 observed observe VBN cord-010092-uftc8inx 10473 12 . . . cord-010092-uftc8inx 10474 1 Since since IN cord-010092-uftc8inx 10474 2 the the DT cord-010092-uftc8inx 10474 3 allele allele NN cord-010092-uftc8inx 10474 4 frequencies frequency NNS cord-010092-uftc8inx 10474 5 of of IN cord-010092-uftc8inx 10474 6 HNA HNA NNP cord-010092-uftc8inx 10474 7 -1 -1 NNP cord-010092-uftc8inx 10474 8 , , , cord-010092-uftc8inx 10474 9 -3 -3 NNP cord-010092-uftc8inx 10474 10 - - SYM cord-010092-uftc8inx 10474 11 5 5 CD cord-010092-uftc8inx 10474 12 for for IN cord-010092-uftc8inx 10474 13 hematological hematological JJ cord-010092-uftc8inx 10474 14 patients patient NNS cord-010092-uftc8inx 10474 15 and and CC cord-010092-uftc8inx 10474 16 donors donor NNS cord-010092-uftc8inx 10474 17 did do VBD cord-010092-uftc8inx 10474 18 not not RB cord-010092-uftc8inx 10474 19 have have VB cord-010092-uftc8inx 10474 20 statistically statistically RB cord-010092-uftc8inx 10474 21 significant significant JJ cord-010092-uftc8inx 10474 22 differences difference NNS cord-010092-uftc8inx 10474 23 , , , cord-010092-uftc8inx 10474 24 possible possible JJ cord-010092-uftc8inx 10474 25 HNA HNA NNP cord-010092-uftc8inx 10474 26 incompatibilities incompatibility NNS cord-010092-uftc8inx 10474 27 and and CC cord-010092-uftc8inx 10474 28 risk risk NN cord-010092-uftc8inx 10474 29 of of IN cord-010092-uftc8inx 10474 30 HNA HNA NNP cord-010092-uftc8inx 10474 31 alloimmunization alloimmunization NN cord-010092-uftc8inx 10474 32 were be VBD cord-010092-uftc8inx 10474 33 estimated estimate VBN cord-010092-uftc8inx 10474 34 based base VBN cord-010092-uftc8inx 10474 35 on on IN cord-010092-uftc8inx 10474 36 the the DT cord-010092-uftc8inx 10474 37 obtained obtain VBN cord-010092-uftc8inx 10474 38 data datum NNS cord-010092-uftc8inx 10474 39 on on IN cord-010092-uftc8inx 10474 40 the the DT cord-010092-uftc8inx 10474 41 allele allele NN cord-010092-uftc8inx 10474 42 and and CC cord-010092-uftc8inx 10474 43 genotype genotype NN cord-010092-uftc8inx 10474 44 frequencies frequency NNS cord-010092-uftc8inx 10474 45 of of IN cord-010092-uftc8inx 10474 46 HNA HNA NNP cord-010092-uftc8inx 10474 47 in in IN cord-010092-uftc8inx 10474 48 a a DT cord-010092-uftc8inx 10474 49 group group NN cord-010092-uftc8inx 10474 50 that that WDT cord-010092-uftc8inx 10474 51 combines combine VBZ cord-010092-uftc8inx 10474 52 donors donor NNS cord-010092-uftc8inx 10474 53 and and CC cord-010092-uftc8inx 10474 54 hematological hematological JJ cord-010092-uftc8inx 10474 55 patients patient NNS cord-010092-uftc8inx 10474 56 ( ( -LRB- cord-010092-uftc8inx 10474 57 n n NN cord-010092-uftc8inx 10474 58 = = SYM cord-010092-uftc8inx 10474 59 605 605 CD cord-010092-uftc8inx 10474 60 ) ) -RRB- cord-010092-uftc8inx 10474 61 . . . cord-010092-uftc8inx 10475 1 The the DT cord-010092-uftc8inx 10475 2 predicted predict VBN cord-010092-uftc8inx 10475 3 risk risk NN cord-010092-uftc8inx 10475 4 of of IN cord-010092-uftc8inx 10475 5 HNA-1 HNA-1 NNP cord-010092-uftc8inx 10475 6 , , , cord-010092-uftc8inx 10475 7 -3 -3 NNP cord-010092-uftc8inx 10475 8 , , , cord-010092-uftc8inx 10475 9 -4 -4 NNP cord-010092-uftc8inx 10475 10 , , , cord-010092-uftc8inx 10475 11 -5 -5 NNP cord-010092-uftc8inx 10475 12 incompatibilities incompatibility NNS cord-010092-uftc8inx 10475 13 in in IN cord-010092-uftc8inx 10475 14 this this DT cord-010092-uftc8inx 10475 15 cohort cohort NN cord-010092-uftc8inx 10475 16 were be VBD cord-010092-uftc8inx 10475 17 34.9 34.9 CD cord-010092-uftc8inx 10475 18 % % NN cord-010092-uftc8inx 10475 19 , , , cord-010092-uftc8inx 10475 20 26.9 26.9 CD cord-010092-uftc8inx 10475 21 % % NN cord-010092-uftc8inx 10475 22 , , , cord-010092-uftc8inx 10475 23 19 19 CD cord-010092-uftc8inx 10475 24 % % NN cord-010092-uftc8inx 10475 25 , , , cord-010092-uftc8inx 10475 26 and and CC cord-010092-uftc8inx 10475 27 32.9 32.9 CD cord-010092-uftc8inx 10475 28 % % NN cord-010092-uftc8inx 10475 29 , , , cord-010092-uftc8inx 10475 30 respectively respectively RB cord-010092-uftc8inx 10475 31 . . . cord-010092-uftc8inx 10476 1 The the DT cord-010092-uftc8inx 10476 2 possible possible JJ cord-010092-uftc8inx 10476 3 risk risk NN cord-010092-uftc8inx 10476 4 of of IN cord-010092-uftc8inx 10476 5 HNA-1a HNA-1a NNP cord-010092-uftc8inx 10476 6 , , , cord-010092-uftc8inx 10476 7 -1bd -1bd CD cord-010092-uftc8inx 10476 8 , , , cord-010092-uftc8inx 10476 9 and and CC cord-010092-uftc8inx 10476 10 -1bc -1bc VBZ cord-010092-uftc8inx 10476 11 alloimmunization alloimmunization NN cord-010092-uftc8inx 10476 12 were be VBD cord-010092-uftc8inx 10476 13 0.233 0.233 CD cord-010092-uftc8inx 10476 14 , , , cord-010092-uftc8inx 10476 15 0.143 0.143 CD cord-010092-uftc8inx 10476 16 , , , cord-010092-uftc8inx 10476 17 and and CC cord-010092-uftc8inx 10476 18 0.064 0.064 CD cord-010092-uftc8inx 10476 19 , , , cord-010092-uftc8inx 10476 20 respectively respectively RB cord-010092-uftc8inx 10476 21 ; ; : cord-010092-uftc8inx 10476 22 of of IN cord-010092-uftc8inx 10476 23 HNA-3a HNA-3a NNP cord-010092-uftc8inx 10476 24 and and CC cord-010092-uftc8inx 10476 25 -3b -3b HYPH cord-010092-uftc8inx 10476 26 alloimmunization alloimmunization NN cord-010092-uftc8inx 10476 27 , , , cord-010092-uftc8inx 10476 28 0.037 0.037 CD cord-010092-uftc8inx 10476 29 and and CC cord-010092-uftc8inx 10476 30 0.231 0.231 CD cord-010092-uftc8inx 10476 31 ; ; : cord-010092-uftc8inx 10476 32 of of IN cord-010092-uftc8inx 10476 33 HNA-4a HNA-4a NNP cord-010092-uftc8inx 10476 34 and and CC cord-010092-uftc8inx 10476 35 -4b -4b ADD cord-010092-uftc8inx 10476 36 alloimmunization alloimmunization NN cord-010092-uftc8inx 10476 37 , , , cord-010092-uftc8inx 10476 38 0.01 0.01 CD cord-010092-uftc8inx 10476 39 and and CC cord-010092-uftc8inx 10476 40 0.163 0.163 CD cord-010092-uftc8inx 10476 41 ; ; : cord-010092-uftc8inx 10476 42 of of IN cord-010092-uftc8inx 10476 43 HNA-5a HNA-5a NNP cord-010092-uftc8inx 10476 44 and and CC cord-010092-uftc8inx 10476 45 -5b -5b CD cord-010092-uftc8inx 10476 46 alloimmunization alloimmunization NN cord-010092-uftc8inx 10476 47 , , , cord-010092-uftc8inx 10476 48 0.080 0.080 CD cord-010092-uftc8inx 10476 49 and and CC cord-010092-uftc8inx 10476 50 0.250 0.250 CD cord-010092-uftc8inx 10476 51 , , , cord-010092-uftc8inx 10476 52 respectively respectively RB cord-010092-uftc8inx 10476 53 . . . cord-010092-uftc8inx 10477 1 Summary Summary NNP cord-010092-uftc8inx 10477 2 / / SYM cord-010092-uftc8inx 10477 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 10477 4 : : : cord-010092-uftc8inx 10478 1 The the DT cord-010092-uftc8inx 10478 2 information information NN cord-010092-uftc8inx 10478 3 about about IN cord-010092-uftc8inx 10478 4 HNA HNA NNP cord-010092-uftc8inx 10478 5 gene gene NN cord-010092-uftc8inx 10478 6 frequencies frequency NNS cord-010092-uftc8inx 10478 7 can can MD cord-010092-uftc8inx 10478 8 be be VB cord-010092-uftc8inx 10478 9 used use VBN cord-010092-uftc8inx 10478 10 not not RB cord-010092-uftc8inx 10478 11 only only RB cord-010092-uftc8inx 10478 12 in in IN cord-010092-uftc8inx 10478 13 blood blood NN cord-010092-uftc8inx 10478 14 services service NNS cord-010092-uftc8inx 10478 15 for for IN cord-010092-uftc8inx 10478 16 detection detection NN cord-010092-uftc8inx 10478 17 and and CC cord-010092-uftc8inx 10478 18 identification identification NN cord-010092-uftc8inx 10478 19 of of IN cord-010092-uftc8inx 10478 20 HNA HNA NNP cord-010092-uftc8inx 10478 21 alloantibodies alloantibody NNS cord-010092-uftc8inx 10478 22 in in IN cord-010092-uftc8inx 10478 23 donors donor NNS cord-010092-uftc8inx 10478 24 and and CC cord-010092-uftc8inx 10478 25 assessment assessment NN cord-010092-uftc8inx 10478 26 of of IN cord-010092-uftc8inx 10478 27 alloimmunization alloimmunization NN cord-010092-uftc8inx 10478 28 risk risk NN cord-010092-uftc8inx 10478 29 but but CC cord-010092-uftc8inx 10478 30 also also RB cord-010092-uftc8inx 10478 31 for for IN cord-010092-uftc8inx 10478 32 anthropological anthropological JJ cord-010092-uftc8inx 10478 33 studies study NNS cord-010092-uftc8inx 10478 34 . . . cord-010092-uftc8inx 10479 1 Background background NN cord-010092-uftc8inx 10479 2 : : : cord-010092-uftc8inx 10480 1 Non non JJ cord-010092-uftc8inx 10480 2 - - JJ cord-010092-uftc8inx 10480 3 invasive invasive JJ cord-010092-uftc8inx 10480 4 fetal fetal JJ cord-010092-uftc8inx 10480 5 RHD rhd NN cord-010092-uftc8inx 10480 6 genotyping genotyping NN cord-010092-uftc8inx 10480 7 is be VBZ cord-010092-uftc8inx 10480 8 performed perform VBN cord-010092-uftc8inx 10480 9 using use VBG cord-010092-uftc8inx 10480 10 circulating circulate VBG cord-010092-uftc8inx 10480 11 cell cell NN cord-010092-uftc8inx 10480 12 - - HYPH cord-010092-uftc8inx 10480 13 free free JJ cord-010092-uftc8inx 10480 14 fetal fetal JJ cord-010092-uftc8inx 10480 15 DNA dna NN cord-010092-uftc8inx 10480 16 from from IN cord-010092-uftc8inx 10480 17 maternal maternal JJ cord-010092-uftc8inx 10480 18 plasma plasma NN cord-010092-uftc8inx 10480 19 sample sample NN cord-010092-uftc8inx 10480 20 and and CC cord-010092-uftc8inx 10480 21 real real JJ cord-010092-uftc8inx 10480 22 - - HYPH cord-010092-uftc8inx 10480 23 time time NN cord-010092-uftc8inx 10480 24 polymerase polymerase NN cord-010092-uftc8inx 10480 25 chain chain NN cord-010092-uftc8inx 10480 26 reaction reaction NN cord-010092-uftc8inx 10480 27 . . . cord-010092-uftc8inx 10481 1 This this DT cord-010092-uftc8inx 10481 2 antenatal antenatal JJ cord-010092-uftc8inx 10481 3 routine routine JJ cord-010092-uftc8inx 10481 4 DNA dna NN cord-010092-uftc8inx 10481 5 test test NN cord-010092-uftc8inx 10481 6 is be VBZ cord-010092-uftc8inx 10481 7 used use VBN cord-010092-uftc8inx 10481 8 to to TO cord-010092-uftc8inx 10481 9 target target VB cord-010092-uftc8inx 10481 10 Rh Rh NNP cord-010092-uftc8inx 10481 11 - - HYPH cord-010092-uftc8inx 10481 12 Ig Ig NNP cord-010092-uftc8inx 10481 13 administration administration NN cord-010092-uftc8inx 10481 14 to to TO cord-010092-uftc8inx 10481 15 prevent prevent VB cord-010092-uftc8inx 10481 16 hemolytic hemolytic JJ cord-010092-uftc8inx 10481 17 disease disease NN cord-010092-uftc8inx 10481 18 of of IN cord-010092-uftc8inx 10481 19 the the DT cord-010092-uftc8inx 10481 20 newborn newborn NN cord-010092-uftc8inx 10481 21 . . . cord-010092-uftc8inx 10482 1 Aims aim VBZ cord-010092-uftc8inx 10482 2 : : : cord-010092-uftc8inx 10483 1 The the DT cord-010092-uftc8inx 10483 2 aim aim NN cord-010092-uftc8inx 10483 3 of of IN cord-010092-uftc8inx 10483 4 this this DT cord-010092-uftc8inx 10483 5 study study NN cord-010092-uftc8inx 10483 6 is be VBZ cord-010092-uftc8inx 10483 7 to to TO cord-010092-uftc8inx 10483 8 characterize characterize VB cord-010092-uftc8inx 10483 9 maternal maternal JJ cord-010092-uftc8inx 10483 10 RHD RHD NNP cord-010092-uftc8inx 10483 11 variants variant NNS cord-010092-uftc8inx 10483 12 responsible responsible JJ cord-010092-uftc8inx 10483 13 for for IN cord-010092-uftc8inx 10483 14 indeterminate indeterminate JJ cord-010092-uftc8inx 10483 15 results result NNS cord-010092-uftc8inx 10483 16 during during IN cord-010092-uftc8inx 10483 17 fetal fetal JJ cord-010092-uftc8inx 10483 18 RHD rhd NN cord-010092-uftc8inx 10483 19 genotyping genotyping NN cord-010092-uftc8inx 10483 20 due due IN cord-010092-uftc8inx 10483 21 to to IN cord-010092-uftc8inx 10483 22 early early JJ cord-010092-uftc8inx 10483 23 amplification amplification NN cord-010092-uftc8inx 10483 24 of of IN cord-010092-uftc8inx 10483 25 at at RB cord-010092-uftc8inx 10483 26 least least RBS cord-010092-uftc8inx 10483 27 one one CD cord-010092-uftc8inx 10483 28 of of IN cord-010092-uftc8inx 10483 29 the the DT cord-010092-uftc8inx 10483 30 exons exon NNS cord-010092-uftc8inx 10483 31 ( ( -LRB- cord-010092-uftc8inx 10483 32 5 5 CD cord-010092-uftc8inx 10483 33 , , , cord-010092-uftc8inx 10483 34 7 7 CD cord-010092-uftc8inx 10483 35 or or CC cord-010092-uftc8inx 10483 36 10 10 CD cord-010092-uftc8inx 10483 37 ) ) -RRB- cord-010092-uftc8inx 10483 38 of of IN cord-010092-uftc8inx 10483 39 the the DT cord-010092-uftc8inx 10483 40 RHD RHD NNP cord-010092-uftc8inx 10483 41 gene gene NN cord-010092-uftc8inx 10483 42 . . . cord-010092-uftc8inx 10484 1 Methods method NNS cord-010092-uftc8inx 10484 2 : : : cord-010092-uftc8inx 10485 1 2004 2004 CD cord-010092-uftc8inx 10485 2 samples sample NNS cord-010092-uftc8inx 10485 3 were be VBD cord-010092-uftc8inx 10485 4 tested test VBN cord-010092-uftc8inx 10485 5 from from IN cord-010092-uftc8inx 10485 6 01/12/2017 01/12/2017 CD cord-010092-uftc8inx 10485 7 to to IN cord-010092-uftc8inx 10485 8 01/12/2018 01/12/2018 CD cord-010092-uftc8inx 10485 9 using use VBG cord-010092-uftc8inx 10485 10 Free free JJ cord-010092-uftc8inx 10485 11 DNA DNA NNP cord-010092-uftc8inx 10485 12 Fetal Fetal NNP cord-010092-uftc8inx 10485 13 Kit kit NN cord-010092-uftc8inx 10485 14 â â . cord-010092-uftc8inx 10486 1 RhD. RhD. NNP cord-010092-uftc8inx 10486 2 44 44 CD cord-010092-uftc8inx 10486 3 samples sample NNS cord-010092-uftc8inx 10486 4 ( ( -LRB- cord-010092-uftc8inx 10486 5 2,2 2,2 CD cord-010092-uftc8inx 10486 6 % % NN cord-010092-uftc8inx 10486 7 ) ) -RRB- cord-010092-uftc8inx 10486 8 yielded yield VBD cord-010092-uftc8inx 10486 9 a a DT cord-010092-uftc8inx 10486 10 premature premature JJ cord-010092-uftc8inx 10486 11 signal signal NN cord-010092-uftc8inx 10486 12 for for IN cord-010092-uftc8inx 10486 13 one one CD cord-010092-uftc8inx 10486 14 or or CC cord-010092-uftc8inx 10486 15 more more JJR cord-010092-uftc8inx 10486 16 exons exon NNS cord-010092-uftc8inx 10486 17 of of IN cord-010092-uftc8inx 10486 18 the the DT cord-010092-uftc8inx 10486 19 RHD RHD NNP cord-010092-uftc8inx 10486 20 gene gene NN cord-010092-uftc8inx 10486 21 . . . cord-010092-uftc8inx 10487 1 After after IN cord-010092-uftc8inx 10487 2 extraction extraction NN cord-010092-uftc8inx 10487 3 of of IN cord-010092-uftc8inx 10487 4 maternal maternal JJ cord-010092-uftc8inx 10487 5 cellular cellular JJ cord-010092-uftc8inx 10487 6 DNA dna NN cord-010092-uftc8inx 10487 7 , , , cord-010092-uftc8inx 10487 8 the the DT cord-010092-uftc8inx 10487 9 maternal maternal JJ cord-010092-uftc8inx 10487 10 RHD RHD NNP cord-010092-uftc8inx 10487 11 was be VBD cord-010092-uftc8inx 10487 12 characterized characterize VBN cord-010092-uftc8inx 10487 13 using use VBG cord-010092-uftc8inx 10487 14 RHD RHD NNP cord-010092-uftc8inx 10487 15 BeadChip BeadChip NNP cord-010092-uftc8inx 10487 16 assay assay NN cord-010092-uftc8inx 10487 17 ( ( -LRB- cord-010092-uftc8inx 10487 18 Immucor Immucor NNP cord-010092-uftc8inx 10487 19 / / SYM cord-010092-uftc8inx 10487 20 BioArray BioArray NNP cord-010092-uftc8inx 10487 21 ) ) -RRB- cord-010092-uftc8inx 10487 22 . . . cord-010092-uftc8inx 10488 1 RHDIIIa RHDIIIa NNS cord-010092-uftc8inx 10488 2 - - HYPH cord-010092-uftc8inx 10488 3 CE(4 ce(4 NN cord-010092-uftc8inx 10488 4 - - HYPH cord-010092-uftc8inx 10488 5 7)-D 7)-D NNP cord-010092-uftc8inx 10488 6 Summary Summary NNP cord-010092-uftc8inx 10488 7 / / SYM cord-010092-uftc8inx 10488 8 Conclusions Conclusions NNPS cord-010092-uftc8inx 10488 9 : : : cord-010092-uftc8inx 10489 1 Greater great JJR cord-010092-uftc8inx 10489 2 diversity diversity NN cord-010092-uftc8inx 10489 3 is be VBZ cord-010092-uftc8inx 10489 4 observed observe VBN cord-010092-uftc8inx 10489 5 in in IN cord-010092-uftc8inx 10489 6 the the DT cord-010092-uftc8inx 10489 7 Caucasian caucasian JJ cord-010092-uftc8inx 10489 8 population population NN cord-010092-uftc8inx 10489 9 rather rather RB cord-010092-uftc8inx 10489 10 than than IN cord-010092-uftc8inx 10489 11 in in IN cord-010092-uftc8inx 10489 12 the the DT cord-010092-uftc8inx 10489 13 Afro Afro NNP cord-010092-uftc8inx 10489 14 - - HYPH cord-010092-uftc8inx 10489 15 Caribbean Caribbean NNP cord-010092-uftc8inx 10489 16 . . . cord-010092-uftc8inx 10490 1 65 65 CD cord-010092-uftc8inx 10490 2 % % NN cord-010092-uftc8inx 10490 3 of of IN cord-010092-uftc8inx 10490 4 the the DT cord-010092-uftc8inx 10490 5 identified identify VBN cord-010092-uftc8inx 10490 6 variants variant NNS cord-010092-uftc8inx 10490 7 are be VBP cord-010092-uftc8inx 10490 8 RHD RHD NNP cord-010092-uftc8inx 10490 9 negative negative JJ cord-010092-uftc8inx 10490 10 alleles allele NNS cord-010092-uftc8inx 10490 11 including include VBG cord-010092-uftc8inx 10490 12 alleles allele NNS cord-010092-uftc8inx 10490 13 leading lead VBG cord-010092-uftc8inx 10490 14 to to IN cord-010092-uftc8inx 10490 15 partial partial JJ cord-010092-uftc8inx 10490 16 RH2 RH2 NNP cord-010092-uftc8inx 10490 17 antigen antigen NNP cord-010092-uftc8inx 10490 18 expression expression NN cord-010092-uftc8inx 10490 19 . . . cord-010092-uftc8inx 10491 1 Unexpected unexpected JJ cord-010092-uftc8inx 10491 2 alleles allele NNS cord-010092-uftc8inx 10491 3 are be VBP cord-010092-uftc8inx 10491 4 found find VBN cord-010092-uftc8inx 10491 5 such such JJ cord-010092-uftc8inx 10491 6 as as IN cord-010092-uftc8inx 10491 7 weak weak JJ cord-010092-uftc8inx 10491 8 D d NN cord-010092-uftc8inx 10491 9 type type NN cord-010092-uftc8inx 10491 10 1 1 CD cord-010092-uftc8inx 10491 11 , , , cord-010092-uftc8inx 10491 12 2 2 CD cord-010092-uftc8inx 10491 13 , , , cord-010092-uftc8inx 10491 14 5 5 CD cord-010092-uftc8inx 10491 15 or or CC cord-010092-uftc8inx 10491 16 11 11 CD cord-010092-uftc8inx 10491 17 . . . cord-010092-uftc8inx 10492 1 These these DT cord-010092-uftc8inx 10492 2 data datum NNS cord-010092-uftc8inx 10492 3 underline underline VBP cord-010092-uftc8inx 10492 4 the the DT cord-010092-uftc8inx 10492 5 benefits benefit NNS cord-010092-uftc8inx 10492 6 of of IN cord-010092-uftc8inx 10492 7 maternal maternal JJ cord-010092-uftc8inx 10492 8 RHD rhd NN cord-010092-uftc8inx 10492 9 genotyping genotyping NN cord-010092-uftc8inx 10492 10 when when WRB cord-010092-uftc8inx 10492 11 abnormal abnormal JJ cord-010092-uftc8inx 10492 12 early early JJ cord-010092-uftc8inx 10492 13 signals signal NNS cord-010092-uftc8inx 10492 14 are be VBP cord-010092-uftc8inx 10492 15 detected detect VBN cord-010092-uftc8inx 10492 16 during during IN cord-010092-uftc8inx 10492 17 noninvasive noninvasive JJ cord-010092-uftc8inx 10492 18 fetal fetal JJ cord-010092-uftc8inx 10492 19 RHD rhd NN cord-010092-uftc8inx 10492 20 genotyping genotyping NN cord-010092-uftc8inx 10492 21 . . . cord-010092-uftc8inx 10493 1 Background background NN cord-010092-uftc8inx 10493 2 : : : cord-010092-uftc8inx 10494 1 A a DT cord-010092-uftc8inx 10494 2 considerable considerable JJ cord-010092-uftc8inx 10494 3 number number NN cord-010092-uftc8inx 10494 4 of of IN cord-010092-uftc8inx 10494 5 RHD RHD NNP cord-010092-uftc8inx 10494 6 alleles allele NNS cord-010092-uftc8inx 10494 7 responsible responsible JJ cord-010092-uftc8inx 10494 8 for for IN cord-010092-uftc8inx 10494 9 weak weak JJ cord-010092-uftc8inx 10494 10 D d NN cord-010092-uftc8inx 10494 11 phenotypes phenotype NNS cord-010092-uftc8inx 10494 12 have have VBP cord-010092-uftc8inx 10494 13 been be VBN cord-010092-uftc8inx 10494 14 identified identify VBN cord-010092-uftc8inx 10494 15 . . . cord-010092-uftc8inx 10495 1 Serologic Serologic NNP cord-010092-uftc8inx 10495 2 determination determination NN cord-010092-uftc8inx 10495 3 of of IN cord-010092-uftc8inx 10495 4 these these DT cord-010092-uftc8inx 10495 5 phenotypes phenotype NNS cord-010092-uftc8inx 10495 6 is be VBZ cord-010092-uftc8inx 10495 7 often often RB cord-010092-uftc8inx 10495 8 doubtful doubtful JJ cord-010092-uftc8inx 10495 9 and and CC cord-010092-uftc8inx 10495 10 makes make VBZ cord-010092-uftc8inx 10495 11 genetic genetic JJ cord-010092-uftc8inx 10495 12 analysis analysis NN cord-010092-uftc8inx 10495 13 of of IN cord-010092-uftc8inx 10495 14 RHD RHD NNP cord-010092-uftc8inx 10495 15 gene gene NN cord-010092-uftc8inx 10495 16 highly highly RB cord-010092-uftc8inx 10495 17 desirable desirable JJ cord-010092-uftc8inx 10495 18 in in IN cord-010092-uftc8inx 10495 19 transfusion transfusion NN cord-010092-uftc8inx 10495 20 recipients recipient NNS cord-010092-uftc8inx 10495 21 and and CC cord-010092-uftc8inx 10495 22 pregnant pregnant JJ cord-010092-uftc8inx 10495 23 women woman NNS cord-010092-uftc8inx 10495 24 . . . cord-010092-uftc8inx 10496 1 DNA dna NN cord-010092-uftc8inx 10496 2 - - HYPH cord-010092-uftc8inx 10496 3 based base VBN cord-010092-uftc8inx 10496 4 methods method NNS cord-010092-uftc8inx 10496 5 are be VBP cord-010092-uftc8inx 10496 6 useful useful JJ cord-010092-uftc8inx 10496 7 for for IN cord-010092-uftc8inx 10496 8 enhancing enhance VBG cord-010092-uftc8inx 10496 9 immunohematology immunohematology NN cord-010092-uftc8inx 10496 10 typing type VBG cord-010092-uftc8inx 10496 11 in in IN cord-010092-uftc8inx 10496 12 doubtful doubtful JJ cord-010092-uftc8inx 10496 13 D d NN cord-010092-uftc8inx 10496 14 phenotypes phenotype NNS cord-010092-uftc8inx 10496 15 at at IN cord-010092-uftc8inx 10496 16 pregnant pregnant JJ cord-010092-uftc8inx 10496 17 women woman NNS cord-010092-uftc8inx 10496 18 . . . cord-010092-uftc8inx 10497 1 Aims aim VBZ cord-010092-uftc8inx 10497 2 : : : cord-010092-uftc8inx 10497 3 Determination determination NN cord-010092-uftc8inx 10497 4 of of IN cord-010092-uftc8inx 10497 5 the the DT cord-010092-uftc8inx 10497 6 RHD RHD NNP cord-010092-uftc8inx 10497 7 gene gene NN cord-010092-uftc8inx 10497 8 in in IN cord-010092-uftc8inx 10497 9 a a DT cord-010092-uftc8inx 10497 10 cohort cohort NN cord-010092-uftc8inx 10497 11 of of IN cord-010092-uftc8inx 10497 12 pregnant pregnant JJ cord-010092-uftc8inx 10497 13 women woman NNS cord-010092-uftc8inx 10497 14 with with IN cord-010092-uftc8inx 10497 15 doubtful doubtful JJ cord-010092-uftc8inx 10497 16 D d NN cord-010092-uftc8inx 10497 17 phenotypes phenotype NNS cord-010092-uftc8inx 10497 18 . . . cord-010092-uftc8inx 10498 1 Methods method NNS cord-010092-uftc8inx 10498 2 : : : cord-010092-uftc8inx 10499 1 Determination determination NN cord-010092-uftc8inx 10499 2 of of IN cord-010092-uftc8inx 10499 3 the the DT cord-010092-uftc8inx 10499 4 RhD rhd NN cord-010092-uftc8inx 10499 5 phenotyping phenotyping NN cord-010092-uftc8inx 10499 6 was be VBD cord-010092-uftc8inx 10499 7 performed perform VBN cord-010092-uftc8inx 10499 8 with with IN cord-010092-uftc8inx 10499 9 microagglutination microagglutination NN cord-010092-uftc8inx 10499 10 technique technique NN cord-010092-uftc8inx 10499 11 BioRad BioRad NNP cord-010092-uftc8inx 10499 12 and and CC cord-010092-uftc8inx 10499 13 Ortho Ortho NNP cord-010092-uftc8inx 10499 14 Diagnostic Diagnostic NNP cord-010092-uftc8inx 10499 15 simultaneously simultaneously RB cord-010092-uftc8inx 10499 16 . . . cord-010092-uftc8inx 10500 1 RHD RHD NNP cord-010092-uftc8inx 10500 2 genotyping genotyping NN cord-010092-uftc8inx 10500 3 was be VBD cord-010092-uftc8inx 10500 4 performed perform VBN cord-010092-uftc8inx 10500 5 on on IN cord-010092-uftc8inx 10500 6 20 20 CD cord-010092-uftc8inx 10500 7 cases case NNS cord-010092-uftc8inx 10500 8 with with IN cord-010092-uftc8inx 10500 9 D d NN cord-010092-uftc8inx 10500 10 typing type VBG cord-010092-uftc8inx 10500 11 serological serological JJ cord-010092-uftc8inx 10500 12 discrepancies discrepancy NNS cord-010092-uftc8inx 10500 13 with with IN cord-010092-uftc8inx 10500 14 Ready Ready NNP cord-010092-uftc8inx 10500 15 - - HYPH cord-010092-uftc8inx 10500 16 to to IN cord-010092-uftc8inx 10500 17 - - HYPH cord-010092-uftc8inx 10500 18 use use NN cord-010092-uftc8inx 10500 19 Inno Inno NNP cord-010092-uftc8inx 10500 20 - - HYPH cord-010092-uftc8inx 10500 21 train train NN cord-010092-uftc8inx 10500 22 RBC RBC NNP cord-010092-uftc8inx 10500 23 - - HYPH cord-010092-uftc8inx 10500 24 Ready Ready NNP cord-010092-uftc8inx 10500 25 Gene Gene NNP cord-010092-uftc8inx 10500 26 CDE CDE NNP cord-010092-uftc8inx 10500 27 and and CC cord-010092-uftc8inx 10500 28 RBC RBC NNP cord-010092-uftc8inx 10500 29 - - HYPH cord-010092-uftc8inx 10500 30 Ready Ready NNP cord-010092-uftc8inx 10500 31 Gene Gene NNP cord-010092-uftc8inx 10500 32 D D NNP cord-010092-uftc8inx 10500 33 weak weak JJ cord-010092-uftc8inx 10500 34 test test NN cord-010092-uftc8inx 10500 35 kits kit NNS cord-010092-uftc8inx 10500 36 based base VBN cord-010092-uftc8inx 10500 37 on on IN cord-010092-uftc8inx 10500 38 polymerase polymerase NN cord-010092-uftc8inx 10500 39 chain chain NN cord-010092-uftc8inx 10500 40 reaction reaction NN cord-010092-uftc8inx 10500 41 with with IN cord-010092-uftc8inx 10500 42 sequence sequence NN cord-010092-uftc8inx 10500 43 - - HYPH cord-010092-uftc8inx 10500 44 specific specific JJ cord-010092-uftc8inx 10500 45 priming priming NN cord-010092-uftc8inx 10500 46 ( ( -LRB- cord-010092-uftc8inx 10500 47 PCR PCR NNP cord-010092-uftc8inx 10500 48 - - HYPH cord-010092-uftc8inx 10500 49 SSP SSP NNP cord-010092-uftc8inx 10500 50 ) ) -RRB- cord-010092-uftc8inx 10500 51 to to IN cord-010092-uftc8inx 10500 52 unclear unclear JJ cord-010092-uftc8inx 10500 53 serologic serologic JJ cord-010092-uftc8inx 10500 54 findings finding NNS cord-010092-uftc8inx 10500 55 . . . cord-010092-uftc8inx 10501 1 Results result NNS cord-010092-uftc8inx 10501 2 : : : cord-010092-uftc8inx 10502 1 Molecular molecular JJ cord-010092-uftc8inx 10502 2 analyses analysis NNS cord-010092-uftc8inx 10502 3 showed show VBD cord-010092-uftc8inx 10502 4 16 16 CD cord-010092-uftc8inx 10502 5 of of IN cord-010092-uftc8inx 10502 6 20 20 CD cord-010092-uftc8inx 10502 7 ( ( -LRB- cord-010092-uftc8inx 10502 8 80 80 CD cord-010092-uftc8inx 10502 9 % % NN cord-010092-uftc8inx 10502 10 ) ) -RRB- cord-010092-uftc8inx 10503 1 pregnant pregnant JJ cord-010092-uftc8inx 10503 2 women woman NNS cord-010092-uftc8inx 10503 3 were be VBD cord-010092-uftc8inx 10503 4 RHD*weak RHD*weak NNP cord-010092-uftc8inx 10503 5 D D NNP cord-010092-uftc8inx 10503 6 type type NN cord-010092-uftc8inx 10503 7 1 1 CD cord-010092-uftc8inx 10503 8 and and CC cord-010092-uftc8inx 10503 9 not not RB cord-010092-uftc8inx 10503 10 at at IN cord-010092-uftc8inx 10503 11 risk risk NN cord-010092-uftc8inx 10503 12 for for IN cord-010092-uftc8inx 10503 13 anti anti NNP cord-010092-uftc8inx 10503 14 - - JJ cord-010092-uftc8inx 10503 15 D. D. NNP cord-010092-uftc8inx 10504 1 RHD*weak RHD*weak NNP cord-010092-uftc8inx 10504 2 D D NNP cord-010092-uftc8inx 10504 3 type type NN cord-010092-uftc8inx 10504 4 3 3 CD cord-010092-uftc8inx 10504 5 were be VBD cord-010092-uftc8inx 10504 6 typed type VBN cord-010092-uftc8inx 10504 7 in in IN cord-010092-uftc8inx 10504 8 3 3 CD cord-010092-uftc8inx 10504 9 cases case NNS cord-010092-uftc8inx 10504 10 ( ( -LRB- cord-010092-uftc8inx 10504 11 15 15 CD cord-010092-uftc8inx 10504 12 % % NN cord-010092-uftc8inx 10504 13 ) ) -RRB- cord-010092-uftc8inx 10504 14 and and CC cord-010092-uftc8inx 10504 15 1 1 CD cord-010092-uftc8inx 10504 16 case case NN cord-010092-uftc8inx 10504 17 was be VBD cord-010092-uftc8inx 10504 18 RHD*weak RHD*weak NNP cord-010092-uftc8inx 10504 19 partial partial JJ cord-010092-uftc8inx 10504 20 4.0 4.0 CD cord-010092-uftc8inx 10504 21 and and CC cord-010092-uftc8inx 10504 22 potentially potentially RB cord-010092-uftc8inx 10504 23 at at IN cord-010092-uftc8inx 10504 24 risk risk NN cord-010092-uftc8inx 10504 25 for for IN cord-010092-uftc8inx 10504 26 being be VBG cord-010092-uftc8inx 10504 27 alloimmunized alloimmunize VBN cord-010092-uftc8inx 10504 28 producing produce VBG cord-010092-uftc8inx 10504 29 anti anti JJ cord-010092-uftc8inx 10504 30 - - JJ cord-010092-uftc8inx 10504 31 D d JJ cord-010092-uftc8inx 10504 32 allo allo NN cord-010092-uftc8inx 10504 33 - - HYPH cord-010092-uftc8inx 10504 34 antibodies antibody NNS cord-010092-uftc8inx 10504 35 . . . cord-010092-uftc8inx 10505 1 Summary Summary NNP cord-010092-uftc8inx 10505 2 / / SYM cord-010092-uftc8inx 10505 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 10505 4 : : : cord-010092-uftc8inx 10506 1 Appropriate appropriate JJ cord-010092-uftc8inx 10506 2 classification classification NN cord-010092-uftc8inx 10506 3 of of IN cord-010092-uftc8inx 10506 4 RhD rhd NN cord-010092-uftc8inx 10506 5 phenotypes phenotype NNS cord-010092-uftc8inx 10506 6 is be VBZ cord-010092-uftc8inx 10506 7 recommended recommend VBN cord-010092-uftc8inx 10506 8 for for IN cord-010092-uftc8inx 10506 9 correct correct JJ cord-010092-uftc8inx 10506 10 indication indication NN cord-010092-uftc8inx 10506 11 of of IN cord-010092-uftc8inx 10506 12 RhIG rhig NN cord-010092-uftc8inx 10506 13 in in IN cord-010092-uftc8inx 10506 14 pregnant pregnant JJ cord-010092-uftc8inx 10506 15 women woman NNS cord-010092-uftc8inx 10506 16 . . . cord-010092-uftc8inx 10507 1 However however RB cord-010092-uftc8inx 10507 2 , , , cord-010092-uftc8inx 10507 3 the the DT cord-010092-uftc8inx 10507 4 serologic serologic JJ cord-010092-uftc8inx 10507 5 differences difference NNS cord-010092-uftc8inx 10507 6 between between IN cord-010092-uftc8inx 10507 7 RhD rhd NN cord-010092-uftc8inx 10507 8 - - HYPH cord-010092-uftc8inx 10507 9 negative negative JJ cord-010092-uftc8inx 10507 10 and and CC cord-010092-uftc8inx 10507 11 RhD rhd NN cord-010092-uftc8inx 10507 12 - - HYPH cord-010092-uftc8inx 10507 13 positive positive JJ cord-010092-uftc8inx 10507 14 pregnant pregnant JJ cord-010092-uftc8inx 10507 15 women woman NNS cord-010092-uftc8inx 10507 16 is be VBZ cord-010092-uftc8inx 10507 17 a a DT cord-010092-uftc8inx 10507 18 real real JJ cord-010092-uftc8inx 10507 19 problem problem NN cord-010092-uftc8inx 10507 20 for for IN cord-010092-uftc8inx 10507 21 unnecessary unnecessary JJ cord-010092-uftc8inx 10507 22 application application NN cord-010092-uftc8inx 10507 23 of of IN cord-010092-uftc8inx 10507 24 RhIG rhig NN cord-010092-uftc8inx 10507 25 prophylaxis prophylaxis NN cord-010092-uftc8inx 10507 26 in in IN cord-010092-uftc8inx 10507 27 pregnant pregnant JJ cord-010092-uftc8inx 10507 28 women woman NNS cord-010092-uftc8inx 10507 29 with with IN cord-010092-uftc8inx 10507 30 D d NN cord-010092-uftc8inx 10507 31 variants variant NNS cord-010092-uftc8inx 10507 32 . . . cord-010092-uftc8inx 10508 1 Conclusion conclusion NN cord-010092-uftc8inx 10508 2 : : : cord-010092-uftc8inx 10509 1 Antenatal antenatal JJ cord-010092-uftc8inx 10509 2 RhIG rhig NN cord-010092-uftc8inx 10509 3 prophylaxis prophylaxis NN cord-010092-uftc8inx 10509 4 is be VBZ cord-010092-uftc8inx 10509 5 useful useful JJ cord-010092-uftc8inx 10509 6 in in IN cord-010092-uftc8inx 10509 7 RhD rhd NN cord-010092-uftc8inx 10509 8 negative negative JJ cord-010092-uftc8inx 10509 9 pregnant pregnant JJ cord-010092-uftc8inx 10509 10 women woman NNS cord-010092-uftc8inx 10509 11 . . . cord-010092-uftc8inx 10510 1 With with IN cord-010092-uftc8inx 10510 2 genotyping genotyping NN cord-010092-uftc8inx 10510 3 we -PRON- PRP cord-010092-uftc8inx 10510 4 found find VBD cord-010092-uftc8inx 10510 5 that that IN cord-010092-uftc8inx 10510 6 95 95 CD cord-010092-uftc8inx 10510 7 % % NN cord-010092-uftc8inx 10510 8 of of IN cord-010092-uftc8inx 10510 9 serological serological JJ cord-010092-uftc8inx 10510 10 doubtful doubtful JJ cord-010092-uftc8inx 10510 11 RhD rhd NN cord-010092-uftc8inx 10510 12 negative negative JJ cord-010092-uftc8inx 10510 13 women woman NNS cord-010092-uftc8inx 10510 14 was be VBD cord-010092-uftc8inx 10510 15 D d NN cord-010092-uftc8inx 10510 16 variants variant NNS cord-010092-uftc8inx 10510 17 that that WDT cord-010092-uftc8inx 10510 18 not not RB cord-010092-uftc8inx 10510 19 produce produce VBP cord-010092-uftc8inx 10510 20 anti anti AFX cord-010092-uftc8inx 10510 21 D d NN cord-010092-uftc8inx 10510 22 antibodies antibody NNS cord-010092-uftc8inx 10510 23 . . . cord-010092-uftc8inx 10511 1 In in IN cord-010092-uftc8inx 10511 2 that that DT cord-010092-uftc8inx 10511 3 cases case NNS cord-010092-uftc8inx 10511 4 those those DT cord-010092-uftc8inx 10511 5 RhIG rhig NN cord-010092-uftc8inx 10511 6 prophylaxis prophylaxis NN cord-010092-uftc8inx 10511 7 was be VBD cord-010092-uftc8inx 10511 8 unnecessary unnecessary JJ cord-010092-uftc8inx 10511 9 and and CC cord-010092-uftc8inx 10511 10 harmful harmful JJ cord-010092-uftc8inx 10511 11 as as IN cord-010092-uftc8inx 10511 12 a a DT cord-010092-uftc8inx 10511 13 product product NN cord-010092-uftc8inx 10511 14 of of IN cord-010092-uftc8inx 10511 15 human human JJ cord-010092-uftc8inx 10511 16 origin origin NN cord-010092-uftc8inx 10511 17 . . . cord-010092-uftc8inx 10512 1 On on IN cord-010092-uftc8inx 10512 2 other other JJ cord-010092-uftc8inx 10512 3 hand hand NN cord-010092-uftc8inx 10512 4 there there EX cord-010092-uftc8inx 10512 5 is be VBZ cord-010092-uftc8inx 10512 6 a a DT cord-010092-uftc8inx 10512 7 save save NN cord-010092-uftc8inx 10512 8 up up IN cord-010092-uftc8inx 10512 9 of of IN cord-010092-uftc8inx 10512 10 a a DT cord-010092-uftc8inx 10512 11 stock stock NN cord-010092-uftc8inx 10512 12 of of IN cord-010092-uftc8inx 10512 13 RhIG rhig NN cord-010092-uftc8inx 10512 14 which which WDT cord-010092-uftc8inx 10512 15 is be VBZ cord-010092-uftc8inx 10512 16 any any DT cord-010092-uftc8inx 10512 17 way way NN cord-010092-uftc8inx 10512 18 in in IN cord-010092-uftc8inx 10512 19 deficit deficit NN cord-010092-uftc8inx 10512 20 . . . cord-010092-uftc8inx 10513 1 Is be VBZ cord-010092-uftc8inx 10513 2 it -PRON- PRP cord-010092-uftc8inx 10513 3 time time NN cord-010092-uftc8inx 10513 4 to to TO cord-010092-uftc8inx 10513 5 think think VB cord-010092-uftc8inx 10513 6 about about IN cord-010092-uftc8inx 10513 7 cost cost NN cord-010092-uftc8inx 10513 8 benefit benefit NN cord-010092-uftc8inx 10513 9 of of IN cord-010092-uftc8inx 10513 10 RhIG rhig NN cord-010092-uftc8inx 10513 11 prophylaxis prophylaxis NN cord-010092-uftc8inx 10513 12 and and CC cord-010092-uftc8inx 10513 13 genotyping genotype VBG cord-010092-uftc8inx 10513 14 in in IN cord-010092-uftc8inx 10513 15 pregnant pregnant JJ cord-010092-uftc8inx 10513 16 women woman NNS cord-010092-uftc8inx 10513 17 . . . cord-010092-uftc8inx 10514 1 Background background NN cord-010092-uftc8inx 10514 2 : : : cord-010092-uftc8inx 10515 1 In in IN cord-010092-uftc8inx 10515 2 May May NNP cord-010092-uftc8inx 10515 3 2018 2018 CD cord-010092-uftc8inx 10515 4 , , , cord-010092-uftc8inx 10515 5 UK UK NNP cord-010092-uftc8inx 10515 6 NEQAS NEQAS NNP cord-010092-uftc8inx 10515 7 ( ( -LRB- cord-010092-uftc8inx 10515 8 BTLP BTLP NNP cord-010092-uftc8inx 10515 9 ) ) -RRB- cord-010092-uftc8inx 10515 10 created create VBD cord-010092-uftc8inx 10515 11 an an DT cord-010092-uftc8inx 10515 12 External External NNP cord-010092-uftc8inx 10515 13 Quality Quality NNP cord-010092-uftc8inx 10515 14 Assessment Assessment NNP cord-010092-uftc8inx 10515 15 ( ( -LRB- cord-010092-uftc8inx 10515 16 EQA EQA NNP cord-010092-uftc8inx 10515 17 ) ) -RRB- cord-010092-uftc8inx 10515 18 sample sample NN cord-010092-uftc8inx 10515 19 designed design VBN cord-010092-uftc8inx 10515 20 to to TO cord-010092-uftc8inx 10515 21 mimic mimic VB cord-010092-uftc8inx 10515 22 a a DT cord-010092-uftc8inx 10515 23 Feto Feto NNP cord-010092-uftc8inx 10515 24 - - HYPH cord-010092-uftc8inx 10515 25 Maternal Maternal NNP cord-010092-uftc8inx 10515 26 Haemorrhage Haemorrhage NNP cord-010092-uftc8inx 10515 27 ( ( -LRB- cord-010092-uftc8inx 10515 28 FMH FMH NNP cord-010092-uftc8inx 10515 29 ) ) -RRB- cord-010092-uftc8inx 10515 30 bleed bleed NN cord-010092-uftc8inx 10515 31 of of IN cord-010092-uftc8inx 10515 32 3 3 CD cord-010092-uftc8inx 10515 33 mL. mL. NNS cord-010092-uftc8inx 10516 1 All all DT cord-010092-uftc8inx 10516 2 material material NN cord-010092-uftc8inx 10516 3 used use VBD cord-010092-uftc8inx 10516 4 passed pass VBN cord-010092-uftc8inx 10516 5 pre pre JJ cord-010092-uftc8inx 10516 6 - - JJ cord-010092-uftc8inx 10516 7 acceptance acceptance JJ cord-010092-uftc8inx 10516 8 serological serological JJ cord-010092-uftc8inx 10516 9 testing testing NN cord-010092-uftc8inx 10516 10 ; ; : cord-010092-uftc8inx 10516 11 samples sample NNS cord-010092-uftc8inx 10516 12 were be VBD cord-010092-uftc8inx 10516 13 dispatched dispatch VBN cord-010092-uftc8inx 10516 14 to to IN cord-010092-uftc8inx 10516 15 298 298 CD cord-010092-uftc8inx 10516 16 participants participant NNS cord-010092-uftc8inx 10516 17 in in IN cord-010092-uftc8inx 10516 18 17 17 CD cord-010092-uftc8inx 10516 19 countries country NNS cord-010092-uftc8inx 10516 20 . . . cord-010092-uftc8inx 10517 1 Post post JJ cord-010092-uftc8inx 10517 2 - - JJ cord-010092-uftc8inx 10517 3 dispatch dispatch JJ cord-010092-uftc8inx 10517 4 testing testing NN cord-010092-uftc8inx 10517 5 by by IN cord-010092-uftc8inx 10517 6 flow flow NN cord-010092-uftc8inx 10517 7 cytometry cytometry NN cord-010092-uftc8inx 10517 8 ( ( -LRB- cord-010092-uftc8inx 10517 9 FC FC NNP cord-010092-uftc8inx 10517 10 ) ) -RRB- cord-010092-uftc8inx 10517 11 using use VBG cord-010092-uftc8inx 10517 12 an an DT cord-010092-uftc8inx 10517 13 anti anti JJ cord-010092-uftc8inx 10517 14 - - JJ cord-010092-uftc8inx 10517 15 D d JJ cord-010092-uftc8inx 10517 16 marker marker NN cord-010092-uftc8inx 10517 17 showed show VBD cord-010092-uftc8inx 10517 18 a a DT cord-010092-uftc8inx 10517 19 bleed bleed NN cord-010092-uftc8inx 10517 20 volume volume NN cord-010092-uftc8inx 10517 21 of of IN cord-010092-uftc8inx 10517 22 1.1 1.1 CD cord-010092-uftc8inx 10517 23 mL mL NNS cord-010092-uftc8inx 10517 24 so so IN cord-010092-uftc8inx 10517 25 an an DT cord-010092-uftc8inx 10517 26 investigation investigation NN cord-010092-uftc8inx 10517 27 was be VBD cord-010092-uftc8inx 10517 28 initiated initiate VBN cord-010092-uftc8inx 10517 29 . . . cord-010092-uftc8inx 10518 1 Aims aim VBZ cord-010092-uftc8inx 10518 2 : : : cord-010092-uftc8inx 10519 1 To to TO cord-010092-uftc8inx 10519 2 determine determine VB cord-010092-uftc8inx 10519 3 the the DT cord-010092-uftc8inx 10519 4 cause cause NN cord-010092-uftc8inx 10519 5 of of IN cord-010092-uftc8inx 10519 6 the the DT cord-010092-uftc8inx 10519 7 unexpectedly unexpectedly RB cord-010092-uftc8inx 10519 8 low low JJ cord-010092-uftc8inx 10519 9 bleed bleed NN cord-010092-uftc8inx 10519 10 volume volume NN cord-010092-uftc8inx 10519 11 and and CC cord-010092-uftc8inx 10519 12 what what WDT cord-010092-uftc8inx 10519 13 lessons lesson NNS cord-010092-uftc8inx 10519 14 could could MD cord-010092-uftc8inx 10519 15 be be VB cord-010092-uftc8inx 10519 16 learnt learn VBN cord-010092-uftc8inx 10519 17 . . . cord-010092-uftc8inx 10520 1 Methods method NNS cord-010092-uftc8inx 10520 2 : : : cord-010092-uftc8inx 10521 1 Production production NN cord-010092-uftc8inx 10521 2 methodology methodology NN cord-010092-uftc8inx 10521 3 and and CC cord-010092-uftc8inx 10521 4 results result NNS cord-010092-uftc8inx 10521 5 of of IN cord-010092-uftc8inx 10521 6 pre pre JJ cord-010092-uftc8inx 10521 7 - - JJ cord-010092-uftc8inx 10521 8 acceptance acceptance JJ cord-010092-uftc8inx 10521 9 testing testing NN cord-010092-uftc8inx 10521 10 were be VBD cord-010092-uftc8inx 10521 11 reviewed review VBN cord-010092-uftc8inx 10521 12 . . . cord-010092-uftc8inx 10522 1 FC FC NNP cord-010092-uftc8inx 10522 2 testing testing NN cord-010092-uftc8inx 10522 3 was be VBD cord-010092-uftc8inx 10522 4 repeated repeat VBN cord-010092-uftc8inx 10522 5 , , , cord-010092-uftc8inx 10522 6 plots plot NNS cord-010092-uftc8inx 10522 7 examined examine VBN cord-010092-uftc8inx 10522 8 , , , cord-010092-uftc8inx 10522 9 and and CC cord-010092-uftc8inx 10522 10 the the DT cord-010092-uftc8inx 10522 11 FMH FMH NNP cord-010092-uftc8inx 10522 12 Scientific Scientific NNP cord-010092-uftc8inx 10522 13 Advisory Advisory NNP cord-010092-uftc8inx 10522 14 Group Group NNP cord-010092-uftc8inx 10522 15 consulted consult VBD cord-010092-uftc8inx 10522 16 for for IN cord-010092-uftc8inx 10522 17 advice advice NN cord-010092-uftc8inx 10522 18 . . . cord-010092-uftc8inx 10523 1 Further further RB cord-010092-uftc8inx 10523 2 FC FC NNP cord-010092-uftc8inx 10523 3 testing testing NN cord-010092-uftc8inx 10523 4 was be VBD cord-010092-uftc8inx 10523 5 performed perform VBN cord-010092-uftc8inx 10523 6 at at IN cord-010092-uftc8inx 10523 7 WBS WBS NNP cord-010092-uftc8inx 10523 8 using use VBG cord-010092-uftc8inx 10523 9 alternative alternative JJ cord-010092-uftc8inx 10523 10 markers marker NNS cord-010092-uftc8inx 10523 11 , , , cord-010092-uftc8inx 10523 12 and and CC cord-010092-uftc8inx 10523 13 the the DT cord-010092-uftc8inx 10523 14 material material NN cord-010092-uftc8inx 10523 15 used use VBN cord-010092-uftc8inx 10523 16 was be VBD cord-010092-uftc8inx 10523 17 investigated investigate VBN cord-010092-uftc8inx 10523 18 at at IN cord-010092-uftc8inx 10523 19 IBGRL IBGRL NNP cord-010092-uftc8inx 10523 20 . . . cord-010092-uftc8inx 10524 1 Participant participant NN cord-010092-uftc8inx 10524 2 results result NNS cord-010092-uftc8inx 10524 3 were be VBD cord-010092-uftc8inx 10524 4 examined examine VBN cord-010092-uftc8inx 10524 5 to to TO cord-010092-uftc8inx 10524 6 determine determine VB cord-010092-uftc8inx 10524 7 if if IN cord-010092-uftc8inx 10524 8 the the DT cord-010092-uftc8inx 10524 9 sample sample NN cord-010092-uftc8inx 10524 10 should should MD cord-010092-uftc8inx 10524 11 be be VB cord-010092-uftc8inx 10524 12 withdrawn withdraw VBN cord-010092-uftc8inx 10524 13 from from IN cord-010092-uftc8inx 10524 14 scoring score VBG cord-010092-uftc8inx 10524 15 . . . cord-010092-uftc8inx 10525 1 A a DT cord-010092-uftc8inx 10525 2 questionnaire questionnaire NN cord-010092-uftc8inx 10525 3 on on IN cord-010092-uftc8inx 10525 4 how how WRB cord-010092-uftc8inx 10525 5 results result NNS cord-010092-uftc8inx 10525 6 were be VBD cord-010092-uftc8inx 10525 7 managed manage VBN cord-010092-uftc8inx 10525 8 was be VBD cord-010092-uftc8inx 10525 9 sent send VBN cord-010092-uftc8inx 10525 10 to to IN cord-010092-uftc8inx 10525 11 the the DT cord-010092-uftc8inx 10525 12 36 36 CD cord-010092-uftc8inx 10525 13 participants participant NNS cord-010092-uftc8inx 10525 14 using use VBG cord-010092-uftc8inx 10525 15 FC FC NNP cord-010092-uftc8inx 10525 16 with with IN cord-010092-uftc8inx 10525 17 an an DT cord-010092-uftc8inx 10525 18 anti anti JJ cord-010092-uftc8inx 10525 19 - - JJ cord-010092-uftc8inx 10525 20 D d JJ cord-010092-uftc8inx 10525 21 marker marker NN cord-010092-uftc8inx 10525 22 . . . cord-010092-uftc8inx 10526 1 Results result NNS cord-010092-uftc8inx 10526 2 : : : cord-010092-uftc8inx 10527 1 A a DT cord-010092-uftc8inx 10527 2 material material NN cord-010092-uftc8inx 10527 3 production production NN cord-010092-uftc8inx 10527 4 methodology methodology NN cord-010092-uftc8inx 10527 5 review review NN cord-010092-uftc8inx 10527 6 showed show VBD cord-010092-uftc8inx 10527 7 no no DT cord-010092-uftc8inx 10527 8 obvious obvious JJ cord-010092-uftc8inx 10527 9 cause cause NN cord-010092-uftc8inx 10527 10 of of IN cord-010092-uftc8inx 10527 11 the the DT cord-010092-uftc8inx 10527 12 erroneous erroneous JJ cord-010092-uftc8inx 10527 13 in in IN cord-010092-uftc8inx 10527 14 - - HYPH cord-010092-uftc8inx 10527 15 house house NN cord-010092-uftc8inx 10527 16 result result NN cord-010092-uftc8inx 10527 17 . . . cord-010092-uftc8inx 10528 1 Review Review NNP cord-010092-uftc8inx 10528 2 of of IN cord-010092-uftc8inx 10528 3 pre pre JJ cord-010092-uftc8inx 10528 4 - - JJ cord-010092-uftc8inx 10528 5 acceptance acceptance JJ cord-010092-uftc8inx 10528 6 testing testing NN cord-010092-uftc8inx 10528 7 images image NNS cord-010092-uftc8inx 10528 8 showed show VBD cord-010092-uftc8inx 10528 9 no no DT cord-010092-uftc8inx 10528 10 issues issue NNS cord-010092-uftc8inx 10528 11 , , , cord-010092-uftc8inx 10528 12 further further RB cord-010092-uftc8inx 10528 13 D d NN cord-010092-uftc8inx 10528 14 - - HYPH cord-010092-uftc8inx 10528 15 typing typing NN cord-010092-uftc8inx 10528 16 of of IN cord-010092-uftc8inx 10528 17 the the DT cord-010092-uftc8inx 10528 18 cord cord NN cord-010092-uftc8inx 10528 19 showed show VBD cord-010092-uftc8inx 10528 20 2 2 CD cord-010092-uftc8inx 10528 21 + + SYM cord-010092-uftc8inx 10528 22 reactions reaction NNS cord-010092-uftc8inx 10528 23 vs. vs. IN cord-010092-uftc8inx 10528 24 two two CD cord-010092-uftc8inx 10528 25 reagents reagent NNS cord-010092-uftc8inx 10528 26 by by IN cord-010092-uftc8inx 10528 27 tube tube NN cord-010092-uftc8inx 10528 28 , , , cord-010092-uftc8inx 10528 29 cf cf NNP cord-010092-uftc8inx 10528 30 . . NNP cord-010092-uftc8inx 10528 31 4 4 CD cord-010092-uftc8inx 10528 32 + + CC cord-010092-uftc8inx 10528 33 with with IN cord-010092-uftc8inx 10528 34 two two CD cord-010092-uftc8inx 10528 35 different different JJ cord-010092-uftc8inx 10528 36 reagents reagent NNS cord-010092-uftc8inx 10528 37 by by IN cord-010092-uftc8inx 10528 38 column column NN cord-010092-uftc8inx 10528 39 agglutination agglutination NN cord-010092-uftc8inx 10528 40 technology technology NN cord-010092-uftc8inx 10528 41 . . . cord-010092-uftc8inx 10529 1 Repeat repeat VB cord-010092-uftc8inx 10529 2 FC FC NNP cord-010092-uftc8inx 10529 3 testing testing NN cord-010092-uftc8inx 10529 4 using use VBG cord-010092-uftc8inx 10529 5 the the DT cord-010092-uftc8inx 10529 6 anti anti JJ cord-010092-uftc8inx 10529 7 - - JJ cord-010092-uftc8inx 10529 8 D d JJ cord-010092-uftc8inx 10529 9 marker marker NN cord-010092-uftc8inx 10529 10 gave give VBD cord-010092-uftc8inx 10529 11 similar similar JJ cord-010092-uftc8inx 10529 12 results result NNS cord-010092-uftc8inx 10529 13 ; ; : cord-010092-uftc8inx 10529 14 however however RB cord-010092-uftc8inx 10529 15 , , , cord-010092-uftc8inx 10529 16 closer close JJR cord-010092-uftc8inx 10529 17 examination examination NN cord-010092-uftc8inx 10529 18 of of IN cord-010092-uftc8inx 10529 19 the the DT cord-010092-uftc8inx 10529 20 plots plot NNS cord-010092-uftc8inx 10529 21 showed show VBD cord-010092-uftc8inx 10529 22 a a DT cord-010092-uftc8inx 10529 23 left left JJ cord-010092-uftc8inx 10529 24 shift shift NN cord-010092-uftc8inx 10529 25 in in IN cord-010092-uftc8inx 10529 26 the the DT cord-010092-uftc8inx 10529 27 positive positive JJ cord-010092-uftc8inx 10529 28 peak peak NN cord-010092-uftc8inx 10529 29 , , , cord-010092-uftc8inx 10529 30 indicating indicate VBG cord-010092-uftc8inx 10529 31 reduced reduce VBN cord-010092-uftc8inx 10529 32 fluorochrome fluorochrome NN cord-010092-uftc8inx 10529 33 binding binding NN cord-010092-uftc8inx 10529 34 , , , cord-010092-uftc8inx 10529 35 possibly possibly RB cord-010092-uftc8inx 10529 36 due due JJ cord-010092-uftc8inx 10529 37 to to IN cord-010092-uftc8inx 10529 38 reduced reduce VBN cord-010092-uftc8inx 10529 39 D d NN cord-010092-uftc8inx 10529 40 antigen antigen NN cord-010092-uftc8inx 10529 41 density density NN cord-010092-uftc8inx 10529 42 on on IN cord-010092-uftc8inx 10529 43 the the DT cord-010092-uftc8inx 10529 44 cord cord NN cord-010092-uftc8inx 10529 45 cells cell NNS cord-010092-uftc8inx 10529 46 . . . cord-010092-uftc8inx 10530 1 Further further RB cord-010092-uftc8inx 10530 2 FC FC NNP cord-010092-uftc8inx 10530 3 testing testing NN cord-010092-uftc8inx 10530 4 at at IN cord-010092-uftc8inx 10530 5 WBS WBS NNP cord-010092-uftc8inx 10530 6 demonstrated demonstrate VBD cord-010092-uftc8inx 10530 7 a a DT cord-010092-uftc8inx 10530 8 marked marked JJ cord-010092-uftc8inx 10530 9 reduction reduction NN cord-010092-uftc8inx 10530 10 in in IN cord-010092-uftc8inx 10530 11 fluorescence fluorescence NN cord-010092-uftc8inx 10530 12 intensity intensity NN cord-010092-uftc8inx 10530 13 with with IN cord-010092-uftc8inx 10530 14 an an DT cord-010092-uftc8inx 10530 15 anti anti JJ cord-010092-uftc8inx 10530 16 - - JJ cord-010092-uftc8inx 10530 17 D d JJ cord-010092-uftc8inx 10530 18 marker marker NN cord-010092-uftc8inx 10530 19 . . . cord-010092-uftc8inx 10531 1 Further further JJ cord-010092-uftc8inx 10531 2 investigation investigation NN cord-010092-uftc8inx 10531 3 using use VBG cord-010092-uftc8inx 10531 4 an an DT cord-010092-uftc8inx 10531 5 anti anti JJ cord-010092-uftc8inx 10531 6 - - JJ cord-010092-uftc8inx 10531 7 HbF hbf JJ cord-010092-uftc8inx 10531 8 marker marker NN cord-010092-uftc8inx 10531 9 showed show VBD cord-010092-uftc8inx 10531 10 a a DT cord-010092-uftc8inx 10531 11 bleed bleed NN cord-010092-uftc8inx 10531 12 volume volume NN cord-010092-uftc8inx 10531 13 of of IN cord-010092-uftc8inx 10531 14 3.7 3.7 CD cord-010092-uftc8inx 10531 15 mL ml NN cord-010092-uftc8inx 10531 16 , , , cord-010092-uftc8inx 10531 17 indicating indicate VBG cord-010092-uftc8inx 10531 18 the the DT cord-010092-uftc8inx 10531 19 correct correct JJ cord-010092-uftc8inx 10531 20 proportion proportion NN cord-010092-uftc8inx 10531 21 of of IN cord-010092-uftc8inx 10531 22 cord cord NN cord-010092-uftc8inx 10531 23 material material NN cord-010092-uftc8inx 10531 24 had have VBD cord-010092-uftc8inx 10531 25 been be VBN cord-010092-uftc8inx 10531 26 used use VBN cord-010092-uftc8inx 10531 27 during during IN cord-010092-uftc8inx 10531 28 sample sample NN cord-010092-uftc8inx 10531 29 production production NN cord-010092-uftc8inx 10531 30 . . . cord-010092-uftc8inx 10532 1 Additional additional JJ cord-010092-uftc8inx 10532 2 serology serology NN cord-010092-uftc8inx 10532 3 at at IN cord-010092-uftc8inx 10532 4 IBGRL IBGRL NNP cord-010092-uftc8inx 10532 5 on on IN cord-010092-uftc8inx 10532 6 the the DT cord-010092-uftc8inx 10532 7 cord cord NN cord-010092-uftc8inx 10532 8 material material NN cord-010092-uftc8inx 10532 9 showed show VBD cord-010092-uftc8inx 10532 10 reactions reaction NNS cord-010092-uftc8inx 10532 11 which which WDT cord-010092-uftc8inx 10532 12 were be VBD cord-010092-uftc8inx 10532 13 weaker weak JJR cord-010092-uftc8inx 10532 14 than than IN cord-010092-uftc8inx 10532 15 the the DT cord-010092-uftc8inx 10532 16 control control NN cord-010092-uftc8inx 10532 17 with with IN cord-010092-uftc8inx 10532 18 4/17 4/17 CD cord-010092-uftc8inx 10532 19 anti anti JJ cord-010092-uftc8inx 10532 20 - - JJ cord-010092-uftc8inx 10532 21 D d JJ cord-010092-uftc8inx 10532 22 reagents reagent NNS cord-010092-uftc8inx 10532 23 . . . cord-010092-uftc8inx 10533 1 Overall overall RB cord-010092-uftc8inx 10533 2 , , , cord-010092-uftc8inx 10533 3 the the DT cord-010092-uftc8inx 10533 4 investigation investigation NN cord-010092-uftc8inx 10533 5 supported support VBD cord-010092-uftc8inx 10533 6 the the DT cord-010092-uftc8inx 10533 7 hypothesis hypothesis NN cord-010092-uftc8inx 10533 8 that that IN cord-010092-uftc8inx 10533 9 the the DT cord-010092-uftc8inx 10533 10 cord cord NN cord-010092-uftc8inx 10533 11 material material NN cord-010092-uftc8inx 10533 12 was be VBD cord-010092-uftc8inx 10533 13 D d NN cord-010092-uftc8inx 10533 14 variant variant NN cord-010092-uftc8inx 10533 15 . . . cord-010092-uftc8inx 10534 1 A a DT cord-010092-uftc8inx 10534 2 review review NN cord-010092-uftc8inx 10534 3 of of IN cord-010092-uftc8inx 10534 4 results result NNS cord-010092-uftc8inx 10534 5 submitted submit VBN cord-010092-uftc8inx 10534 6 by by IN cord-010092-uftc8inx 10534 7 participants participant NNS cord-010092-uftc8inx 10534 8 mirrored mirror VBD cord-010092-uftc8inx 10534 9 the the DT cord-010092-uftc8inx 10534 10 FC FC NNP cord-010092-uftc8inx 10534 11 investigation investigation NN cord-010092-uftc8inx 10534 12 and and CC cord-010092-uftc8inx 10534 13 the the DT cord-010092-uftc8inx 10534 14 sample sample NN cord-010092-uftc8inx 10534 15 was be VBD cord-010092-uftc8inx 10534 16 withdrawn withdraw VBN cord-010092-uftc8inx 10534 17 from from IN cord-010092-uftc8inx 10534 18 scoring score VBG cord-010092-uftc8inx 10534 19 , , , cord-010092-uftc8inx 10534 20 as as IN cord-010092-uftc8inx 10534 21 the the DT cord-010092-uftc8inx 10534 22 FC FC NNP cord-010092-uftc8inx 10534 23 median median NN cord-010092-uftc8inx 10534 24 result result NN cord-010092-uftc8inx 10534 25 is be VBZ cord-010092-uftc8inx 10534 26 used use VBN cord-010092-uftc8inx 10534 27 to to TO cord-010092-uftc8inx 10534 28 calculate calculate VB cord-010092-uftc8inx 10534 29 scores score NNS cord-010092-uftc8inx 10534 30 and and CC cord-010092-uftc8inx 10534 31 the the DT cord-010092-uftc8inx 10534 32 D D NNP cord-010092-uftc8inx 10534 33 variant variant NN cord-010092-uftc8inx 10534 34 cord cord NN cord-010092-uftc8inx 10534 35 was be VBD cord-010092-uftc8inx 10534 36 clearly clearly RB cord-010092-uftc8inx 10534 37 affecting affect VBG cord-010092-uftc8inx 10534 38 testing testing NN cord-010092-uftc8inx 10534 39 with with IN cord-010092-uftc8inx 10534 40 an an DT cord-010092-uftc8inx 10534 41 anti anti JJ cord-010092-uftc8inx 10534 42 - - JJ cord-010092-uftc8inx 10534 43 D d JJ cord-010092-uftc8inx 10534 44 marker marker NN cord-010092-uftc8inx 10534 45 . . . cord-010092-uftc8inx 10535 1 The the DT cord-010092-uftc8inx 10535 2 questionnaire questionnaire NN cord-010092-uftc8inx 10535 3 showed show VBD cord-010092-uftc8inx 10535 4 that that IN cord-010092-uftc8inx 10535 5 all all DT cord-010092-uftc8inx 10535 6 16 16 CD cord-010092-uftc8inx 10535 7 respondents respondent NNS cord-010092-uftc8inx 10535 8 examine examine VBP cord-010092-uftc8inx 10535 9 FC FC NNP cord-010092-uftc8inx 10535 10 plots plot NNS cord-010092-uftc8inx 10535 11 and and CC cord-010092-uftc8inx 10535 12 the the DT cord-010092-uftc8inx 10535 13 gating gating NN cord-010092-uftc8inx 10535 14 used use VBN cord-010092-uftc8inx 10535 15 , , , cord-010092-uftc8inx 10535 16 but but CC cord-010092-uftc8inx 10535 17 not not RB cord-010092-uftc8inx 10535 18 all all DT cord-010092-uftc8inx 10535 19 act act VB cord-010092-uftc8inx 10535 20 on on IN cord-010092-uftc8inx 10535 21 them -PRON- PRP cord-010092-uftc8inx 10535 22 before before IN cord-010092-uftc8inx 10535 23 reporting reporting NN cord-010092-uftc8inx 10535 24 results result NNS cord-010092-uftc8inx 10535 25 , , , cord-010092-uftc8inx 10535 26 and and CC cord-010092-uftc8inx 10535 27 not not RB cord-010092-uftc8inx 10535 28 all all DT cord-010092-uftc8inx 10535 29 have have VB cord-010092-uftc8inx 10535 30 a a DT cord-010092-uftc8inx 10535 31 back back NN cord-010092-uftc8inx 10535 32 - - HYPH cord-010092-uftc8inx 10535 33 up up NN cord-010092-uftc8inx 10535 34 plan plan NN cord-010092-uftc8inx 10535 35 for for IN cord-010092-uftc8inx 10535 36 anti anti JJ cord-010092-uftc8inx 10535 37 - - JJ cord-010092-uftc8inx 10535 38 D d JJ cord-010092-uftc8inx 10535 39 Ig ig NN cord-010092-uftc8inx 10535 40 dosing dose VBG cord-010092-uftc8inx 10535 41 in in IN cord-010092-uftc8inx 10535 42 a a DT cord-010092-uftc8inx 10535 43 similar similar JJ cord-010092-uftc8inx 10535 44 situation situation NN cord-010092-uftc8inx 10535 45 . . . cord-010092-uftc8inx 10536 1 Later later RB cord-010092-uftc8inx 10536 2 sequencing sequencing NN cord-010092-uftc8inx 10536 3 of of IN cord-010092-uftc8inx 10536 4 the the DT cord-010092-uftc8inx 10536 5 D D NNP cord-010092-uftc8inx 10536 6 gene gene NN cord-010092-uftc8inx 10536 7 revealed reveal VBD cord-010092-uftc8inx 10536 8 the the DT cord-010092-uftc8inx 10536 9 cord cord NN cord-010092-uftc8inx 10536 10 donor donor NN cord-010092-uftc8inx 10536 11 to to TO cord-010092-uftc8inx 10536 12 be be VB cord-010092-uftc8inx 10536 13 DVII DVII NNP cord-010092-uftc8inx 10536 14 which which WDT cord-010092-uftc8inx 10536 15 can can MD cord-010092-uftc8inx 10536 16 have have VB cord-010092-uftc8inx 10536 17 a a DT cord-010092-uftc8inx 10536 18 lower low JJR cord-010092-uftc8inx 10536 19 than than IN cord-010092-uftc8inx 10536 20 normal normal JJ cord-010092-uftc8inx 10536 21 D d NN cord-010092-uftc8inx 10536 22 antigen antigen NN cord-010092-uftc8inx 10536 23 density density NN cord-010092-uftc8inx 10536 24 . . . cord-010092-uftc8inx 10537 1 Summary Summary NNP cord-010092-uftc8inx 10537 2 / / SYM cord-010092-uftc8inx 10537 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 10537 4 : : : cord-010092-uftc8inx 10538 1 The the DT cord-010092-uftc8inx 10538 2 use use NN cord-010092-uftc8inx 10538 3 of of IN cord-010092-uftc8inx 10538 4 a a DT cord-010092-uftc8inx 10538 5 D d NN cord-010092-uftc8inx 10538 6 variant variant NN cord-010092-uftc8inx 10538 7 cord cord NN cord-010092-uftc8inx 10538 8 in in IN cord-010092-uftc8inx 10538 9 an an DT cord-010092-uftc8inx 10538 10 EQA EQA NNP cord-010092-uftc8inx 10538 11 sample sample NN cord-010092-uftc8inx 10538 12 was be VBD cord-010092-uftc8inx 10538 13 not not RB cord-010092-uftc8inx 10538 14 planned plan VBN cord-010092-uftc8inx 10538 15 , , , cord-010092-uftc8inx 10538 16 but but CC cord-010092-uftc8inx 10538 17 allowed allow VBD cord-010092-uftc8inx 10538 18 UK UK NNP cord-010092-uftc8inx 10538 19 NEQAS NEQAS NNP cord-010092-uftc8inx 10538 20 to to TO cord-010092-uftc8inx 10538 21 highlight highlight VB cord-010092-uftc8inx 10538 22 some some DT cord-010092-uftc8inx 10538 23 important important JJ cord-010092-uftc8inx 10538 24 learning learning NN cord-010092-uftc8inx 10538 25 points point NNS cord-010092-uftc8inx 10538 26 : : : cord-010092-uftc8inx 10539 1 -Thorough -Thorough : cord-010092-uftc8inx 10539 2 examination examination NN cord-010092-uftc8inx 10539 3 of of IN cord-010092-uftc8inx 10539 4 FC FC NNP cord-010092-uftc8inx 10539 5 plots plot NNS cord-010092-uftc8inx 10539 6 is be VBZ cord-010092-uftc8inx 10539 7 essential essential JJ cord-010092-uftc8inx 10539 8 to to TO cord-010092-uftc8inx 10539 9 avoid avoid VB cord-010092-uftc8inx 10539 10 underestimation underestimation NN cord-010092-uftc8inx 10539 11 of of IN cord-010092-uftc8inx 10539 12 FMH FMH NNP cord-010092-uftc8inx 10539 13 ; ; : cord-010092-uftc8inx 10539 14 a a DT cord-010092-uftc8inx 10539 15 controlled control VBN cord-010092-uftc8inx 10539 16 procedure procedure NN cord-010092-uftc8inx 10539 17 should should MD cord-010092-uftc8inx 10539 18 be be VB cord-010092-uftc8inx 10539 19 in in IN cord-010092-uftc8inx 10539 20 place place NN cord-010092-uftc8inx 10539 21 if if IN cord-010092-uftc8inx 10539 22 modification modification NN cord-010092-uftc8inx 10539 23 of of IN cord-010092-uftc8inx 10539 24 gates gate NNS cord-010092-uftc8inx 10539 25 is be VBZ cord-010092-uftc8inx 10539 26 required require VBN cord-010092-uftc8inx 10539 27 -Access -access NN cord-010092-uftc8inx 10539 28 to to TO cord-010092-uftc8inx 10539 29 cord cord NN cord-010092-uftc8inx 10539 30 / / SYM cord-010092-uftc8inx 10539 31 neonatal neonatal JJ cord-010092-uftc8inx 10539 32 blood blood NN cord-010092-uftc8inx 10539 33 to to TO cord-010092-uftc8inx 10539 34 allow allow VB cord-010092-uftc8inx 10539 35 serological serological JJ cord-010092-uftc8inx 10539 36 investigation investigation NN cord-010092-uftc8inx 10539 37 may may MD cord-010092-uftc8inx 10539 38 be be VB cord-010092-uftc8inx 10539 39 useful useful JJ cord-010092-uftc8inx 10539 40 in in IN cord-010092-uftc8inx 10539 41 a a DT cord-010092-uftc8inx 10539 42 similar similar JJ cord-010092-uftc8inx 10539 43 clinical clinical JJ cord-010092-uftc8inx 10539 44 situation situation NN cord-010092-uftc8inx 10539 45 -It -It : cord-010092-uftc8inx 10539 46 is be VBZ cord-010092-uftc8inx 10539 47 important important JJ cord-010092-uftc8inx 10539 48 to to TO cord-010092-uftc8inx 10539 49 have have VB cord-010092-uftc8inx 10539 50 a a DT cord-010092-uftc8inx 10539 51 back back NN cord-010092-uftc8inx 10539 52 - - HYPH cord-010092-uftc8inx 10539 53 up up NN cord-010092-uftc8inx 10539 54 plan plan NN cord-010092-uftc8inx 10539 55 for for IN cord-010092-uftc8inx 10539 56 issuing issue VBG cord-010092-uftc8inx 10539 57 anti anti JJ cord-010092-uftc8inx 10539 58 - - JJ cord-010092-uftc8inx 10539 59 D d JJ cord-010092-uftc8inx 10539 60 Ig ig NN cord-010092-uftc8inx 10539 61 in in IN cord-010092-uftc8inx 10539 62 the the DT cord-010092-uftc8inx 10539 63 event event NN cord-010092-uftc8inx 10539 64 of of IN cord-010092-uftc8inx 10539 65 an an DT cord-010092-uftc8inx 10539 66 uninterpretable uninterpretable JJ cord-010092-uftc8inx 10539 67 FMH fmh NN cord-010092-uftc8inx 10539 68 result result NN cord-010092-uftc8inx 10540 1 Background background NN cord-010092-uftc8inx 10540 2 : : : cord-010092-uftc8inx 10541 1 Allo allo NN cord-010092-uftc8inx 10541 2 - - HYPH cord-010092-uftc8inx 10541 3 antibodies antibody NNS cord-010092-uftc8inx 10541 4 against against IN cord-010092-uftc8inx 10541 5 fetal fetal JJ cord-010092-uftc8inx 10541 6 blood blood NN cord-010092-uftc8inx 10541 7 group group NN cord-010092-uftc8inx 10541 8 and and CC cord-010092-uftc8inx 10541 9 platelet platelet NN cord-010092-uftc8inx 10541 10 antigens antigen NNS cord-010092-uftc8inx 10541 11 produced produce VBN cord-010092-uftc8inx 10541 12 by by IN cord-010092-uftc8inx 10541 13 antigen antigen NN cord-010092-uftc8inx 10541 14 - - HYPH cord-010092-uftc8inx 10541 15 negative negative JJ cord-010092-uftc8inx 10541 16 pregnant pregnant JJ cord-010092-uftc8inx 10541 17 women woman NNS cord-010092-uftc8inx 10541 18 can can MD cord-010092-uftc8inx 10541 19 cause cause VB cord-010092-uftc8inx 10541 20 hemolytic hemolytic JJ cord-010092-uftc8inx 10541 21 disease disease NN cord-010092-uftc8inx 10541 22 of of IN cord-010092-uftc8inx 10541 23 fetus fetus NN cord-010092-uftc8inx 10541 24 and and CC cord-010092-uftc8inx 10541 25 newborn newborn JJ cord-010092-uftc8inx 10541 26 ( ( -LRB- cord-010092-uftc8inx 10541 27 HDFN HDFN NNP cord-010092-uftc8inx 10541 28 ) ) -RRB- cord-010092-uftc8inx 10541 29 and and CC cord-010092-uftc8inx 10541 30 fetal fetal JJ cord-010092-uftc8inx 10541 31 and and CC cord-010092-uftc8inx 10541 32 neonatal neonatal JJ cord-010092-uftc8inx 10541 33 alloimmune alloimmune JJ cord-010092-uftc8inx 10541 34 thrombocytopenia thrombocytopenia NN cord-010092-uftc8inx 10541 35 ( ( -LRB- cord-010092-uftc8inx 10541 36 FNAIT FNAIT NNP cord-010092-uftc8inx 10541 37 ) ) -RRB- cord-010092-uftc8inx 10541 38 . . . cord-010092-uftc8inx 10542 1 Prediction prediction NN cord-010092-uftc8inx 10542 2 of of IN cord-010092-uftc8inx 10542 3 the the DT cord-010092-uftc8inx 10542 4 fetus fetus NN cord-010092-uftc8inx 10542 5 antigen antigen NN cord-010092-uftc8inx 10542 6 status status NN cord-010092-uftc8inx 10542 7 in in IN cord-010092-uftc8inx 10542 8 immunized immunize VBN cord-010092-uftc8inx 10542 9 women woman NNS cord-010092-uftc8inx 10542 10 is be VBZ cord-010092-uftc8inx 10542 11 important important JJ cord-010092-uftc8inx 10542 12 for for IN cord-010092-uftc8inx 10542 13 making make VBG cord-010092-uftc8inx 10542 14 decisions decision NNS cord-010092-uftc8inx 10542 15 concerning concern VBG cord-010092-uftc8inx 10542 16 further further JJ cord-010092-uftc8inx 10542 17 management management NN cord-010092-uftc8inx 10542 18 of of IN cord-010092-uftc8inx 10542 19 pregnancy pregnancy NN cord-010092-uftc8inx 10542 20 . . . cord-010092-uftc8inx 10543 1 NIPT NIPT NNP cord-010092-uftc8inx 10543 2 is be VBZ cord-010092-uftc8inx 10543 3 widely widely RB cord-010092-uftc8inx 10543 4 used use VBN cord-010092-uftc8inx 10543 5 for for IN cord-010092-uftc8inx 10543 6 determination determination NN cord-010092-uftc8inx 10543 7 of of IN cord-010092-uftc8inx 10543 8 fetal fetal JJ cord-010092-uftc8inx 10543 9 blood blood NN cord-010092-uftc8inx 10543 10 groups group NNS cord-010092-uftc8inx 10543 11 but but CC cord-010092-uftc8inx 10543 12 determination determination NN cord-010092-uftc8inx 10543 13 of of IN cord-010092-uftc8inx 10543 14 proper proper JJ cord-010092-uftc8inx 10543 15 specificity specificity NN cord-010092-uftc8inx 10543 16 in in IN cord-010092-uftc8inx 10543 17 the the DT cord-010092-uftc8inx 10543 18 real real JJ cord-010092-uftc8inx 10543 19 - - HYPH cord-010092-uftc8inx 10543 20 time time NN cord-010092-uftc8inx 10543 21 amplification amplification NN cord-010092-uftc8inx 10543 22 of of IN cord-010092-uftc8inx 10543 23 a a DT cord-010092-uftc8inx 10543 24 single single JJ cord-010092-uftc8inx 10543 25 nucleotide nucleotide JJ cord-010092-uftc8inx 10543 26 polymorphism polymorphism NN cord-010092-uftc8inx 10543 27 ( ( -LRB- cord-010092-uftc8inx 10543 28 SNP SNP NNP cord-010092-uftc8inx 10543 29 ) ) -RRB- cord-010092-uftc8inx 10543 30 , , , cord-010092-uftc8inx 10543 31 such such JJ cord-010092-uftc8inx 10543 32 as as IN cord-010092-uftc8inx 10543 33 K K NNP cord-010092-uftc8inx 10543 34 or or CC cord-010092-uftc8inx 10543 35 HPA-1a HPA-1a NNP cord-010092-uftc8inx 10543 36 , , , cord-010092-uftc8inx 10543 37 requires require VBZ cord-010092-uftc8inx 10543 38 modified modify VBN cord-010092-uftc8inx 10543 39 protocols protocol NNS cord-010092-uftc8inx 10543 40 . . . cord-010092-uftc8inx 10544 1 Droplet Droplet NNP cord-010092-uftc8inx 10544 2 digital digital JJ cord-010092-uftc8inx 10544 3 PCR PCR NNP cord-010092-uftc8inx 10544 4 ( ( -LRB- cord-010092-uftc8inx 10544 5 ddPCR ddPCR NNP cord-010092-uftc8inx 10544 6 ) ) -RRB- cord-010092-uftc8inx 10544 7 permits permit VBZ cord-010092-uftc8inx 10544 8 detection detection NN cord-010092-uftc8inx 10544 9 of of IN cord-010092-uftc8inx 10544 10 low low JJ cord-010092-uftc8inx 10544 11 - - HYPH cord-010092-uftc8inx 10544 12 grade grade NN cord-010092-uftc8inx 10544 13 fetal fetal JJ cord-010092-uftc8inx 10544 14 chimerism chimerism NN cord-010092-uftc8inx 10544 15 in in IN cord-010092-uftc8inx 10544 16 maternal maternal JJ cord-010092-uftc8inx 10544 17 plasma plasma NN cord-010092-uftc8inx 10544 18 DNA dna NN cord-010092-uftc8inx 10544 19 with with IN cord-010092-uftc8inx 10544 20 higher high JJR cord-010092-uftc8inx 10544 21 specificity specificity NN cord-010092-uftc8inx 10544 22 using use VBG cord-010092-uftc8inx 10544 23 allelic allelic JJ cord-010092-uftc8inx 10544 24 discrimination discrimination NN cord-010092-uftc8inx 10544 25 PCR PCR NNP cord-010092-uftc8inx 10544 26 protocols protocol NNS cord-010092-uftc8inx 10544 27 . . . cord-010092-uftc8inx 10545 1 Aims aim VBZ cord-010092-uftc8inx 10545 2 : : : cord-010092-uftc8inx 10546 1 To to TO cord-010092-uftc8inx 10546 2 establish establish VB cord-010092-uftc8inx 10546 3 ddPCR ddpcr FW cord-010092-uftc8inx 10546 4 protocols protocol NNS cord-010092-uftc8inx 10546 5 for for IN cord-010092-uftc8inx 10546 6 non non JJ cord-010092-uftc8inx 10546 7 - - JJ cord-010092-uftc8inx 10546 8 invasive invasive JJ cord-010092-uftc8inx 10546 9 prenatal prenatal JJ cord-010092-uftc8inx 10546 10 diagnostics diagnostic NNS cord-010092-uftc8inx 10546 11 ( ( -LRB- cord-010092-uftc8inx 10546 12 NIPD NIPD NNP cord-010092-uftc8inx 10546 13 ) ) -RRB- cord-010092-uftc8inx 10546 14 of of IN cord-010092-uftc8inx 10546 15 clinically clinically RB cord-010092-uftc8inx 10546 16 important important JJ cord-010092-uftc8inx 10546 17 blood blood NN cord-010092-uftc8inx 10546 18 group group NN cord-010092-uftc8inx 10546 19 antigens antigen NNS cord-010092-uftc8inx 10546 20 . . . cord-010092-uftc8inx 10547 1 Methods method NNS cord-010092-uftc8inx 10547 2 : : : cord-010092-uftc8inx 10548 1 DNA DNA NNP cord-010092-uftc8inx 10548 2 was be VBD cord-010092-uftc8inx 10548 3 isolated isolate VBN cord-010092-uftc8inx 10548 4 from from IN cord-010092-uftc8inx 10548 5 133 133 CD cord-010092-uftc8inx 10548 6 plasma plasma NN cord-010092-uftc8inx 10548 7 samples sample NNS cord-010092-uftc8inx 10548 8 of of IN cord-010092-uftc8inx 10548 9 pregnant pregnant JJ cord-010092-uftc8inx 10548 10 women woman NNS cord-010092-uftc8inx 10548 11 and and CC cord-010092-uftc8inx 10548 12 donors donor NNS cord-010092-uftc8inx 10548 13 with with IN cord-010092-uftc8inx 10548 14 known know VBN cord-010092-uftc8inx 10548 15 genotypes genotype NNS cord-010092-uftc8inx 10548 16 ( ( -LRB- cord-010092-uftc8inx 10548 17 easyMag easymag NN cord-010092-uftc8inx 10548 18 , , , cord-010092-uftc8inx 10548 19 Biomerieux Biomerieux NNP cord-010092-uftc8inx 10548 20 ) ) -RRB- cord-010092-uftc8inx 10548 21 . . . cord-010092-uftc8inx 10549 1 Allelic allelic JJ cord-010092-uftc8inx 10549 2 discrimination discrimination NN cord-010092-uftc8inx 10549 3 protocols protocol NNS cord-010092-uftc8inx 10549 4 for for IN cord-010092-uftc8inx 10549 5 determination determination NN cord-010092-uftc8inx 10549 6 of of IN cord-010092-uftc8inx 10549 7 K K NNP cord-010092-uftc8inx 10549 8 / / SYM cord-010092-uftc8inx 10549 9 k k NNP cord-010092-uftc8inx 10549 10 ( ( -LRB- cord-010092-uftc8inx 10549 11 n n NN cord-010092-uftc8inx 10549 12 = = SYM cord-010092-uftc8inx 10549 13 29 29 CD cord-010092-uftc8inx 10549 14 ) ) -RRB- cord-010092-uftc8inx 10549 15 , , , cord-010092-uftc8inx 10549 16 S S NNP cord-010092-uftc8inx 10549 17 / / SYM cord-010092-uftc8inx 10549 18 s s NN cord-010092-uftc8inx 10550 1 ( ( -LRB- cord-010092-uftc8inx 10550 2 n n NN cord-010092-uftc8inx 10550 3 = = SYM cord-010092-uftc8inx 10550 4 13 13 CD cord-010092-uftc8inx 10550 5 ) ) -RRB- cord-010092-uftc8inx 10550 6 , , , cord-010092-uftc8inx 10550 7 HPA-1a HPA-1a NNP cord-010092-uftc8inx 10550 8 ( ( -LRB- cord-010092-uftc8inx 10550 9 n n NN cord-010092-uftc8inx 10550 10 = = SYM cord-010092-uftc8inx 10550 11 49 49 CD cord-010092-uftc8inx 10550 12 ) ) -RRB- cord-010092-uftc8inx 10550 13 , , , cord-010092-uftc8inx 10550 14 HPA-3 HPA-3 NNP cord-010092-uftc8inx 10551 1 ( ( -LRB- cord-010092-uftc8inx 10551 2 n n NNP cord-010092-uftc8inx 10552 1 = = SYM cord-010092-uftc8inx 10552 2 8) 8) NN cord-010092-uftc8inx 10552 3 , , , cord-010092-uftc8inx 10552 4 HPA-5 HPA-5 NNP cord-010092-uftc8inx 10553 1 ( ( -LRB- cord-010092-uftc8inx 10553 2 n n NN cord-010092-uftc8inx 10553 3 = = SYM cord-010092-uftc8inx 10553 4 14 14 CD cord-010092-uftc8inx 10553 5 ) ) -RRB- cord-010092-uftc8inx 10553 6 , , . cord-010092-uftc8inx 10554 1 HPA-15 HPA-15 NNP cord-010092-uftc8inx 10555 1 ( ( -LRB- cord-010092-uftc8inx 10555 2 n n NN cord-010092-uftc8inx 10555 3 = = SYM cord-010092-uftc8inx 10555 4 20 20 CD cord-010092-uftc8inx 10555 5 ) ) -RRB- cord-010092-uftc8inx 10555 6 genotypes genotype NNS cord-010092-uftc8inx 10555 7 were be VBD cord-010092-uftc8inx 10555 8 performed perform VBN cord-010092-uftc8inx 10555 9 using use VBG cord-010092-uftc8inx 10555 10 ddPCR ddPCR NNP cord-010092-uftc8inx 10555 11 method method NN cord-010092-uftc8inx 10555 12 with with IN cord-010092-uftc8inx 10555 13 Droplet Droplet NNP cord-010092-uftc8inx 10555 14 Digital Digital NNP cord-010092-uftc8inx 10555 15 TM TM NNP cord-010092-uftc8inx 10555 16 ( ( -LRB- cord-010092-uftc8inx 10555 17 Biorad Biorad NNP cord-010092-uftc8inx 10555 18 ) ) -RRB- cord-010092-uftc8inx 10555 19 . . . cord-010092-uftc8inx 10556 1 The the DT cord-010092-uftc8inx 10556 2 results result NNS cord-010092-uftc8inx 10556 3 of of IN cord-010092-uftc8inx 10556 4 allelic allelic JJ cord-010092-uftc8inx 10556 5 discrimination discrimination NN cord-010092-uftc8inx 10556 6 performed perform VBN cord-010092-uftc8inx 10556 7 using use VBG cord-010092-uftc8inx 10556 8 ddPCR ddPCR -LRB- cord-010092-uftc8inx 10556 9 were be VBD cord-010092-uftc8inx 10556 10 concordant concordant JJ cord-010092-uftc8inx 10556 11 with with IN cord-010092-uftc8inx 10556 12 the the DT cord-010092-uftc8inx 10556 13 already already RB cord-010092-uftc8inx 10556 14 known know VBN cord-010092-uftc8inx 10556 15 phenotype phenotype NN cord-010092-uftc8inx 10556 16 / / SYM cord-010092-uftc8inx 10556 17 genotype genotype NN cord-010092-uftc8inx 10556 18 of of IN cord-010092-uftc8inx 10556 19 donors donor NNS cord-010092-uftc8inx 10556 20 and and CC cord-010092-uftc8inx 10556 21 pregnant pregnant JJ cord-010092-uftc8inx 10556 22 women woman NNS cord-010092-uftc8inx 10556 23 . . . cord-010092-uftc8inx 10557 1 DdPCR DdPCR NNP cord-010092-uftc8inx 10557 2 enabled enable VBD cord-010092-uftc8inx 10557 3 the the DT cord-010092-uftc8inx 10557 4 detection detection NN cord-010092-uftc8inx 10557 5 of of IN cord-010092-uftc8inx 10557 6 100 100 CD cord-010092-uftc8inx 10557 7 - - SYM cord-010092-uftc8inx 10557 8 16,000 16,000 CD cord-010092-uftc8inx 10557 9 reads read NNS cord-010092-uftc8inx 10557 10 for for IN cord-010092-uftc8inx 10557 11 total total JJ cord-010092-uftc8inx 10557 12 DNA dna NN cord-010092-uftc8inx 10557 13 from from IN cord-010092-uftc8inx 10557 14 plasma plasma NN cord-010092-uftc8inx 10557 15 in in IN cord-010092-uftc8inx 10557 16 tested test VBN cord-010092-uftc8inx 10557 17 samples sample NNS cord-010092-uftc8inx 10557 18 . . . cord-010092-uftc8inx 10558 1 All all DT cord-010092-uftc8inx 10558 2 fetal fetal JJ cord-010092-uftc8inx 10558 3 results result NNS cord-010092-uftc8inx 10558 4 were be VBD cord-010092-uftc8inx 10558 5 in in IN cord-010092-uftc8inx 10558 6 agreement agreement NN cord-010092-uftc8inx 10558 7 with with IN cord-010092-uftc8inx 10558 8 antigen antigen NN cord-010092-uftc8inx 10558 9 positive positive JJ cord-010092-uftc8inx 10558 10 genotype genotype NN cord-010092-uftc8inx 10558 11 of of IN cord-010092-uftc8inx 10558 12 the the DT cord-010092-uftc8inx 10558 13 neonates neonate NNS cord-010092-uftc8inx 10558 14 and and CC cord-010092-uftc8inx 10558 15 the the DT cord-010092-uftc8inx 10558 16 fetal fetal JJ cord-010092-uftc8inx 10558 17 chimerism chimerism NN cord-010092-uftc8inx 10558 18 was be VBD cord-010092-uftc8inx 10558 19 from from IN cord-010092-uftc8inx 10558 20 0,01 0,01 NN cord-010092-uftc8inx 10558 21 % % NN cord-010092-uftc8inx 10558 22 to to TO cord-010092-uftc8inx 10558 23 26,4 26,4 CD cord-010092-uftc8inx 10558 24 % % NN cord-010092-uftc8inx 10558 25 ( ( -LRB- cord-010092-uftc8inx 10558 26 one one CD cord-010092-uftc8inx 10558 27 case case NN cord-010092-uftc8inx 10558 28 was be VBD cord-010092-uftc8inx 10558 29 for for IN cord-010092-uftc8inx 10558 30 advanced advanced JJ cord-010092-uftc8inx 10558 31 pregnancy pregnancy NN cord-010092-uftc8inx 10558 32 -38 -38 NNP cord-010092-uftc8inx 10558 33 week week NN cord-010092-uftc8inx 10558 34 of of IN cord-010092-uftc8inx 10558 35 gestation gestation NN cord-010092-uftc8inx 10558 36 ) ) -RRB- cord-010092-uftc8inx 10558 37 . . . cord-010092-uftc8inx 10559 1 In in IN cord-010092-uftc8inx 10559 2 19/133 19/133 CD cord-010092-uftc8inx 10559 3 tested test VBN cord-010092-uftc8inx 10559 4 samples sample NNS cord-010092-uftc8inx 10559 5 false false JJ cord-010092-uftc8inx 10559 6 positive positive JJ cord-010092-uftc8inx 10559 7 results result NNS cord-010092-uftc8inx 10559 8 were be VBD cord-010092-uftc8inx 10559 9 detected detect VBN cord-010092-uftc8inx 10559 10 at at IN cord-010092-uftc8inx 10559 11 the the DT cord-010092-uftc8inx 10559 12 level level NN cord-010092-uftc8inx 10559 13 of of IN cord-010092-uftc8inx 10559 14 1 1 CD cord-010092-uftc8inx 10559 15 or or CC cord-010092-uftc8inx 10559 16 2 2 CD cord-010092-uftc8inx 10559 17 unspecific unspecific JJ cord-010092-uftc8inx 10559 18 reads read NNS cord-010092-uftc8inx 10559 19 . . . cord-010092-uftc8inx 10560 1 Summary Summary NNP cord-010092-uftc8inx 10560 2 / / SYM cord-010092-uftc8inx 10560 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 10560 4 : : : cord-010092-uftc8inx 10561 1 The the DT cord-010092-uftc8inx 10561 2 implementation implementation NN cord-010092-uftc8inx 10561 3 of of IN cord-010092-uftc8inx 10561 4 allelic allelic JJ cord-010092-uftc8inx 10561 5 discrimination discrimination NN cord-010092-uftc8inx 10561 6 protocols protocol NNS cord-010092-uftc8inx 10561 7 for for IN cord-010092-uftc8inx 10561 8 ddPCR ddPCR NNP cord-010092-uftc8inx 10561 9 allowed allow VBN cord-010092-uftc8inx 10561 10 detection detection NN cord-010092-uftc8inx 10561 11 of of IN cord-010092-uftc8inx 10561 12 fetal fetal JJ cord-010092-uftc8inx 10561 13 - - HYPH cord-010092-uftc8inx 10561 14 maternal maternal JJ cord-010092-uftc8inx 10561 15 incompatibility incompatibility NN cord-010092-uftc8inx 10561 16 in in IN cord-010092-uftc8inx 10561 17 K K NNP cord-010092-uftc8inx 10561 18 / / SYM cord-010092-uftc8inx 10561 19 k k NNP cord-010092-uftc8inx 10561 20 , , , cord-010092-uftc8inx 10561 21 S S NNP cord-010092-uftc8inx 10561 22 / / SYM cord-010092-uftc8inx 10561 23 s s NNP cord-010092-uftc8inx 10561 24 and and CC cord-010092-uftc8inx 10561 25 HPA-1a HPA-1a NNP cord-010092-uftc8inx 10561 26 , , , cord-010092-uftc8inx 10561 27 -3a -3a NNP cord-010092-uftc8inx 10561 28 / / SYM cord-010092-uftc8inx 10561 29 b b NN cord-010092-uftc8inx 10561 30 , , , cord-010092-uftc8inx 10561 31 -5a -5a NNP cord-010092-uftc8inx 10561 32 / / SYM cord-010092-uftc8inx 10561 33 b b NN cord-010092-uftc8inx 10561 34 , , , cord-010092-uftc8inx 10561 35 -15a -15a : cord-010092-uftc8inx 10561 36 / / SYM cord-010092-uftc8inx 10561 37 b b NN cord-010092-uftc8inx 10561 38 antigens antigen NNS cord-010092-uftc8inx 10561 39 encoded encode VBN cord-010092-uftc8inx 10561 40 by by IN cord-010092-uftc8inx 10561 41 SNP SNP NNP cord-010092-uftc8inx 10561 42 . . . cord-010092-uftc8inx 10562 1 Background background NN cord-010092-uftc8inx 10562 2 : : : cord-010092-uftc8inx 10563 1 In in IN cord-010092-uftc8inx 10563 2 France France NNP cord-010092-uftc8inx 10563 3 , , , cord-010092-uftc8inx 10563 4 for for IN cord-010092-uftc8inx 10563 5 pregnancies pregnancy NNS cord-010092-uftc8inx 10563 6 complicated complicate VBN cord-010092-uftc8inx 10563 7 by by IN cord-010092-uftc8inx 10563 8 anti anti JJ cord-010092-uftc8inx 10563 9 - - JJ cord-010092-uftc8inx 10563 10 D d JJ cord-010092-uftc8inx 10563 11 ( ( -LRB- cord-010092-uftc8inx 10563 12 RH1 RH1 NNP cord-010092-uftc8inx 10563 13 ) ) -RRB- cord-010092-uftc8inx 10563 14 and and CC cord-010092-uftc8inx 10563 15 anti anti JJ cord-010092-uftc8inx 10563 16 - - NN cord-010092-uftc8inx 10563 17 c c JJ cord-010092-uftc8inx 10563 18 ( ( -LRB- cord-010092-uftc8inx 10563 19 RH4 RH4 NNP cord-010092-uftc8inx 10563 20 ) ) -RRB- cord-010092-uftc8inx 10563 21 allo allo NN cord-010092-uftc8inx 10563 22 - - HYPH cord-010092-uftc8inx 10563 23 immunization immunization NN cord-010092-uftc8inx 10563 24 , , , cord-010092-uftc8inx 10563 25 the the DT cord-010092-uftc8inx 10563 26 tests test NNS cord-010092-uftc8inx 10563 27 currently currently RB cord-010092-uftc8inx 10563 28 used use VBD cord-010092-uftc8inx 10563 29 to to TO cord-010092-uftc8inx 10563 30 quantitate quantitate VB cord-010092-uftc8inx 10563 31 maternal maternal JJ cord-010092-uftc8inx 10563 32 antibodies antibody NNS cord-010092-uftc8inx 10563 33 are be VBP cord-010092-uftc8inx 10563 34 tube tube NN cord-010092-uftc8inx 10563 35 method method NN cord-010092-uftc8inx 10563 36 titration titration NN cord-010092-uftc8inx 10563 37 and and CC cord-010092-uftc8inx 10563 38 continuous continuous JJ cord-010092-uftc8inx 10563 39 flow flow NN cord-010092-uftc8inx 10563 40 analysis analysis NN cord-010092-uftc8inx 10563 41 determination determination NN cord-010092-uftc8inx 10563 42 of of IN cord-010092-uftc8inx 10563 43 the the DT cord-010092-uftc8inx 10563 44 antibodies antibody NNS cord-010092-uftc8inx 10563 45 concentration concentration NN cord-010092-uftc8inx 10563 46 . . . cord-010092-uftc8inx 10564 1 Recently recently RB cord-010092-uftc8inx 10564 2 , , , cord-010092-uftc8inx 10564 3 an an DT cord-010092-uftc8inx 10564 4 automated automated JJ cord-010092-uftc8inx 10564 5 assay assay NN cord-010092-uftc8inx 10564 6 was be VBD cord-010092-uftc8inx 10564 7 developed develop VBN cord-010092-uftc8inx 10564 8 using use VBG cord-010092-uftc8inx 10564 9 the the DT cord-010092-uftc8inx 10564 10 column column NN cord-010092-uftc8inx 10564 11 agglutination agglutination NN cord-010092-uftc8inx 10564 12 technology technology NN cord-010092-uftc8inx 10564 13 on on IN cord-010092-uftc8inx 10564 14 the the DT cord-010092-uftc8inx 10564 15 IH-500 IH-500 NNP cord-010092-uftc8inx 10564 16 system system NN cord-010092-uftc8inx 10565 1 ( ( -LRB- cord-010092-uftc8inx 10565 2 Bio Bio NNP cord-010092-uftc8inx 10565 3 - - HYPH cord-010092-uftc8inx 10565 4 Rad Rad NNP cord-010092-uftc8inx 10565 5 â â NN cord-010092-uftc8inx 10565 6 ) ) -RRB- cord-010092-uftc8inx 10565 7 . . . cord-010092-uftc8inx 10566 1 Aims aim VBZ cord-010092-uftc8inx 10566 2 : : : cord-010092-uftc8inx 10566 3 We -PRON- PRP cord-010092-uftc8inx 10566 4 wanted want VBD cord-010092-uftc8inx 10566 5 to to TO cord-010092-uftc8inx 10566 6 evaluate evaluate VB cord-010092-uftc8inx 10566 7 the the DT cord-010092-uftc8inx 10566 8 score score NN cord-010092-uftc8inx 10566 9 , , , cord-010092-uftc8inx 10566 10 calculated calculate VBN cord-010092-uftc8inx 10566 11 from from IN cord-010092-uftc8inx 10566 12 the the DT cord-010092-uftc8inx 10566 13 agglutination agglutination NN cord-010092-uftc8inx 10566 14 profile profile NN cord-010092-uftc8inx 10566 15 of of IN cord-010092-uftc8inx 10566 16 the the DT cord-010092-uftc8inx 10566 17 antibodies antibody NNS cord-010092-uftc8inx 10566 18 on on IN cord-010092-uftc8inx 10566 19 the the DT cord-010092-uftc8inx 10566 20 IH-500 IH-500 NNP cord-010092-uftc8inx 10566 21 system system NN cord-010092-uftc8inx 10566 22 , , , cord-010092-uftc8inx 10566 23 as as IN cord-010092-uftc8inx 10566 24 a a DT cord-010092-uftc8inx 10566 25 quantitative quantitative JJ cord-010092-uftc8inx 10566 26 data datum NNS cord-010092-uftc8inx 10566 27 to to TO cord-010092-uftc8inx 10566 28 appreciate appreciate VB cord-010092-uftc8inx 10566 29 the the DT cord-010092-uftc8inx 10566 30 level level NN cord-010092-uftc8inx 10566 31 of of IN cord-010092-uftc8inx 10566 32 maternal maternal JJ cord-010092-uftc8inx 10566 33 antibodies antibody NNS cord-010092-uftc8inx 10566 34 . . . cord-010092-uftc8inx 10567 1 Methods method NNS cord-010092-uftc8inx 10567 2 : : : cord-010092-uftc8inx 10568 1 Titers titer NNS cord-010092-uftc8inx 10568 2 from from IN cord-010092-uftc8inx 10568 3 29 29 CD cord-010092-uftc8inx 10568 4 samples sample NNS cord-010092-uftc8inx 10568 5 containing contain VBG cord-010092-uftc8inx 10568 6 anti anti JJ cord-010092-uftc8inx 10568 7 - - JJ cord-010092-uftc8inx 10568 8 D d JJ cord-010092-uftc8inx 10568 9 and and CC cord-010092-uftc8inx 10568 10 20 20 CD cord-010092-uftc8inx 10568 11 containing contain VBG cord-010092-uftc8inx 10568 12 anti anti JJ cord-010092-uftc8inx 10568 13 - - NN cord-010092-uftc8inx 10568 14 c c JJ cord-010092-uftc8inx 10568 15 have have VBP cord-010092-uftc8inx 10568 16 been be VBN cord-010092-uftc8inx 10568 17 established establish VBN cord-010092-uftc8inx 10568 18 using use VBG cord-010092-uftc8inx 10568 19 the the DT cord-010092-uftc8inx 10568 20 semi semi RB cord-010092-uftc8inx 10568 21 - - JJ cord-010092-uftc8inx 10568 22 automated automated JJ cord-010092-uftc8inx 10568 23 tube tube NN cord-010092-uftc8inx 10568 24 method method NN cord-010092-uftc8inx 10568 25 performed perform VBN cord-010092-uftc8inx 10568 26 since since IN cord-010092-uftc8inx 10568 27 decades decade NNS cord-010092-uftc8inx 10568 28 in in IN cord-010092-uftc8inx 10568 29 our -PRON- PRP$ cord-010092-uftc8inx 10568 30 lab lab NN cord-010092-uftc8inx 10568 31 and and CC cord-010092-uftc8inx 10568 32 the the DT cord-010092-uftc8inx 10568 33 fully fully RB cord-010092-uftc8inx 10568 34 automated automate VBN cord-010092-uftc8inx 10568 35 gel gel NN cord-010092-uftc8inx 10568 36 method method NN cord-010092-uftc8inx 10568 37 on on IN cord-010092-uftc8inx 10568 38 the the DT cord-010092-uftc8inx 10568 39 IH-500 IH-500 NNP cord-010092-uftc8inx 10568 40 system system NN cord-010092-uftc8inx 10568 41 . . . cord-010092-uftc8inx 10569 1 Scores score NNS cord-010092-uftc8inx 10569 2 were be VBD cord-010092-uftc8inx 10569 3 calculated calculate VBN cord-010092-uftc8inx 10569 4 manually manually RB cord-010092-uftc8inx 10569 5 in in IN cord-010092-uftc8inx 10569 6 both both DT cord-010092-uftc8inx 10569 7 cases case NNS cord-010092-uftc8inx 10569 8 . . . cord-010092-uftc8inx 10570 1 Antibodies antibody NNS cord-010092-uftc8inx 10570 2 concentrations concentration NNS cord-010092-uftc8inx 10570 3 were be VBD cord-010092-uftc8inx 10570 4 also also RB cord-010092-uftc8inx 10570 5 determined determine VBN cord-010092-uftc8inx 10570 6 for for IN cord-010092-uftc8inx 10570 7 all all DT cord-010092-uftc8inx 10570 8 samples sample NNS cord-010092-uftc8inx 10570 9 by by IN cord-010092-uftc8inx 10570 10 continuous continuous JJ cord-010092-uftc8inx 10570 11 flow flow NN cord-010092-uftc8inx 10570 12 analysis analysis NN cord-010092-uftc8inx 10570 13 on on IN cord-010092-uftc8inx 10570 14 our -PRON- PRP$ cord-010092-uftc8inx 10570 15 auto auto NN cord-010092-uftc8inx 10570 16 - - HYPH cord-010092-uftc8inx 10570 17 analyzer analyzer NN cord-010092-uftc8inx 10570 18 device device NN cord-010092-uftc8inx 10571 1 ( ( -LRB- cord-010092-uftc8inx 10571 2 Evolution Evolution NNP cord-010092-uftc8inx 10571 3 III III NNP cord-010092-uftc8inx 10571 4 AMS AMS NNP cord-010092-uftc8inx 10571 5 Alliance Alliance NNP cord-010092-uftc8inx 10571 6 ) ) -RRB- cord-010092-uftc8inx 10571 7 . . . cord-010092-uftc8inx 10572 1 We -PRON- PRP cord-010092-uftc8inx 10572 2 looked look VBD cord-010092-uftc8inx 10572 3 for for IN cord-010092-uftc8inx 10572 4 a a DT cord-010092-uftc8inx 10572 5 possible possible JJ cord-010092-uftc8inx 10572 6 correlation correlation NN cord-010092-uftc8inx 10572 7 between between IN cord-010092-uftc8inx 10572 8 anti anti JJ cord-010092-uftc8inx 10572 9 - - JJ cord-010092-uftc8inx 10572 10 D d JJ cord-010092-uftc8inx 10572 11 and and CC cord-010092-uftc8inx 10572 12 anti anti JJ cord-010092-uftc8inx 10572 13 - - JJ cord-010092-uftc8inx 10572 14 c c JJ cord-010092-uftc8inx 10572 15 scores score NNS cord-010092-uftc8inx 10572 16 and and CC cord-010092-uftc8inx 10572 17 the the DT cord-010092-uftc8inx 10572 18 corresponding correspond VBG cord-010092-uftc8inx 10572 19 concentrations concentration NNS cord-010092-uftc8inx 10572 20 using use VBG cord-010092-uftc8inx 10572 21 the the DT cord-010092-uftc8inx 10572 22 Spearman Spearman NNP cord-010092-uftc8inx 10572 23 correlation correlation NN cord-010092-uftc8inx 10572 24 test test NN cord-010092-uftc8inx 10572 25 . . . cord-010092-uftc8inx 10573 1 Results result NNS cord-010092-uftc8inx 10573 2 : : : cord-010092-uftc8inx 10573 3 Anti anti JJ cord-010092-uftc8inx 10573 4 - - JJ cord-010092-uftc8inx 10573 5 D d JJ cord-010092-uftc8inx 10573 6 tube tube NN cord-010092-uftc8inx 10573 7 and and CC cord-010092-uftc8inx 10573 8 gel gel NN cord-010092-uftc8inx 10573 9 scores score NNS cord-010092-uftc8inx 10573 10 were be VBD cord-010092-uftc8inx 10573 11 significantly significantly RB cord-010092-uftc8inx 10573 12 correlated correlate VBN cord-010092-uftc8inx 10573 13 with with IN cord-010092-uftc8inx 10573 14 the the DT cord-010092-uftc8inx 10573 15 anti anti JJ cord-010092-uftc8inx 10573 16 - - JJ cord-010092-uftc8inx 10573 17 D d JJ cord-010092-uftc8inx 10573 18 concentration concentration NN cord-010092-uftc8inx 10573 19 values value NNS cord-010092-uftc8inx 10573 20 ( ( -LRB- cord-010092-uftc8inx 10573 21 p p NN cord-010092-uftc8inx 10573 22 < < XX cord-010092-uftc8inx 10573 23 0.0001 0.0001 CD cord-010092-uftc8inx 10573 24 , , , cord-010092-uftc8inx 10573 25 r r NN cord-010092-uftc8inx 10573 26 = = SYM cord-010092-uftc8inx 10573 27 0.79 0.79 CD cord-010092-uftc8inx 10573 28 and and CC cord-010092-uftc8inx 10573 29 p p NN cord-010092-uftc8inx 10573 30 < < XX cord-010092-uftc8inx 10573 31 0.0001 0.0001 CD cord-010092-uftc8inx 10573 32 , , , cord-010092-uftc8inx 10573 33 r r NN cord-010092-uftc8inx 10573 34 = = SYM cord-010092-uftc8inx 10573 35 0.82 0.82 CD cord-010092-uftc8inx 10573 36 respectively respectively RB cord-010092-uftc8inx 10573 37 ) ) -RRB- cord-010092-uftc8inx 10573 38 . . . cord-010092-uftc8inx 10574 1 Anti anti JJ cord-010092-uftc8inx 10574 2 - - JJ cord-010092-uftc8inx 10574 3 c c JJ cord-010092-uftc8inx 10574 4 scores score NNS cord-010092-uftc8inx 10574 5 were be VBD cord-010092-uftc8inx 10574 6 also also RB cord-010092-uftc8inx 10574 7 significantly significantly RB cord-010092-uftc8inx 10574 8 correlated correlate VBN cord-010092-uftc8inx 10574 9 with with IN cord-010092-uftc8inx 10574 10 anti anti JJ cord-010092-uftc8inx 10574 11 - - JJ cord-010092-uftc8inx 10574 12 c c JJ cord-010092-uftc8inx 10574 13 concentration concentration NN cord-010092-uftc8inx 10574 14 values value NNS cord-010092-uftc8inx 10574 15 ( ( -LRB- cord-010092-uftc8inx 10574 16 p p NN cord-010092-uftc8inx 10574 17 < < XX cord-010092-uftc8inx 10574 18 0.0001 0.0001 CD cord-010092-uftc8inx 10574 19 ) ) -RRB- cord-010092-uftc8inx 10574 20 but but CC cord-010092-uftc8inx 10574 21 gel gel NN cord-010092-uftc8inx 10574 22 scores score NNS cord-010092-uftc8inx 10574 23 have have VBP cord-010092-uftc8inx 10574 24 a a DT cord-010092-uftc8inx 10574 25 better well JJR cord-010092-uftc8inx 10574 26 correlation correlation NN cord-010092-uftc8inx 10574 27 coefficient coefficient NN cord-010092-uftc8inx 10574 28 than than IN cord-010092-uftc8inx 10574 29 tube tube NN cord-010092-uftc8inx 10574 30 scores score NNS cord-010092-uftc8inx 10574 31 ( ( -LRB- cord-010092-uftc8inx 10574 32 r r NN cord-010092-uftc8inx 10574 33 = = SYM cord-010092-uftc8inx 10574 34 0.78 0.78 CD cord-010092-uftc8inx 10574 35 versus versus IN cord-010092-uftc8inx 10574 36 0.55 0.55 CD cord-010092-uftc8inx 10574 37 ) ) -RRB- cord-010092-uftc8inx 10574 38 . . . cord-010092-uftc8inx 10575 1 It -PRON- PRP cord-010092-uftc8inx 10575 2 was be VBD cord-010092-uftc8inx 10575 3 easier easy JJR cord-010092-uftc8inx 10575 4 to to TO cord-010092-uftc8inx 10575 5 extrapolate extrapolate VB cord-010092-uftc8inx 10575 6 gel gel NN cord-010092-uftc8inx 10575 7 score score NN cord-010092-uftc8inx 10575 8 thresholds threshold NNS cord-010092-uftc8inx 10575 9 than than IN cord-010092-uftc8inx 10575 10 tube tube NN cord-010092-uftc8inx 10575 11 score score NN cord-010092-uftc8inx 10575 12 thresholds threshold NNS cord-010092-uftc8inx 10575 13 from from IN cord-010092-uftc8inx 10575 14 the the DT cord-010092-uftc8inx 10575 15 autoanalyzer autoanalyzer NN cord-010092-uftc8inx 10575 16 values value NNS cord-010092-uftc8inx 10575 17 , , , cord-010092-uftc8inx 10575 18 with with IN cord-010092-uftc8inx 10575 19 the the DT cord-010092-uftc8inx 10575 20 aim aim NN cord-010092-uftc8inx 10575 21 of of IN cord-010092-uftc8inx 10575 22 triggering trigger VBG cord-010092-uftc8inx 10575 23 fetal fetal JJ cord-010092-uftc8inx 10575 24 monitoring monitoring NN cord-010092-uftc8inx 10575 25 by by IN cord-010092-uftc8inx 10575 26 ultrasounds ultrasound NNS cord-010092-uftc8inx 10575 27 and and CC cord-010092-uftc8inx 10575 28 measurements measurement NNS cord-010092-uftc8inx 10575 29 of of IN cord-010092-uftc8inx 10575 30 the the DT cord-010092-uftc8inx 10575 31 peak peak JJ cord-010092-uftc8inx 10575 32 systolic systolic JJ cord-010092-uftc8inx 10575 33 velocity velocity NN cord-010092-uftc8inx 10575 34 in in IN cord-010092-uftc8inx 10575 35 the the DT cord-010092-uftc8inx 10575 36 middle middle JJ cord-010092-uftc8inx 10575 37 cerebral cerebral JJ cord-010092-uftc8inx 10575 38 artery artery NN cord-010092-uftc8inx 10575 39 only only RB cord-010092-uftc8inx 10575 40 for for IN cord-010092-uftc8inx 10575 41 risk risk NN cord-010092-uftc8inx 10575 42 pregnancies pregnancy NNS cord-010092-uftc8inx 10575 43 . . . cord-010092-uftc8inx 10576 1 The the DT cord-010092-uftc8inx 10576 2 determined determined JJ cord-010092-uftc8inx 10576 3 gel gel NN cord-010092-uftc8inx 10576 4 score score NN cord-010092-uftc8inx 10576 5 thresholds threshold NNS cord-010092-uftc8inx 10576 6 were be VBD cord-010092-uftc8inx 10576 7 75 75 CD cord-010092-uftc8inx 10576 8 and and CC cord-010092-uftc8inx 10576 9 35 35 CD cord-010092-uftc8inx 10576 10 , , , cord-010092-uftc8inx 10576 11 corresponding correspond VBG cord-010092-uftc8inx 10576 12 respectively respectively RB cord-010092-uftc8inx 10576 13 to to IN cord-010092-uftc8inx 10576 14 5 5 CD cord-010092-uftc8inx 10576 15 UI UI NNP cord-010092-uftc8inx 10576 16 / / SYM cord-010092-uftc8inx 10576 17 ml ml NN cord-010092-uftc8inx 10576 18 ( ( -LRB- cord-010092-uftc8inx 10576 19 250 250 CD cord-010092-uftc8inx 10576 20 UCHP UCHP NNP cord-010092-uftc8inx 10576 21 / / SYM cord-010092-uftc8inx 10576 22 ml ml NNP cord-010092-uftc8inx 10576 23 ) ) -RRB- cord-010092-uftc8inx 10576 24 of of IN cord-010092-uftc8inx 10576 25 anti anti JJ cord-010092-uftc8inx 10576 26 - - JJ cord-010092-uftc8inx 10576 27 D d JJ cord-010092-uftc8inx 10576 28 and and CC cord-010092-uftc8inx 10576 29 7.5 7.5 CD cord-010092-uftc8inx 10576 30 UI UI NNP cord-010092-uftc8inx 10576 31 / / SYM cord-010092-uftc8inx 10576 32 ml ml NN cord-010092-uftc8inx 10576 33 ( ( -LRB- cord-010092-uftc8inx 10576 34 500 500 CD cord-010092-uftc8inx 10576 35 UCHP UCHP NNP cord-010092-uftc8inx 10576 36 / / SYM cord-010092-uftc8inx 10576 37 ml ml NNP cord-010092-uftc8inx 10576 38 ) ) -RRB- cord-010092-uftc8inx 10576 39 of of IN cord-010092-uftc8inx 10576 40 anti anti JJ cord-010092-uftc8inx 10576 41 - - NN cord-010092-uftc8inx 10576 42 c c JJ cord-010092-uftc8inx 10576 43 . . . cord-010092-uftc8inx 10577 1 Conclusions conclusion NNS cord-010092-uftc8inx 10577 2 : : : cord-010092-uftc8inx 10578 1 Calculating calculate VBG cord-010092-uftc8inx 10578 2 the the DT cord-010092-uftc8inx 10578 3 score score NN cord-010092-uftc8inx 10578 4 from from IN cord-010092-uftc8inx 10578 5 the the DT cord-010092-uftc8inx 10578 6 hemagglutination hemagglutination NN cord-010092-uftc8inx 10578 7 profile profile NN cord-010092-uftc8inx 10578 8 displayed display VBN cord-010092-uftc8inx 10578 9 by by IN cord-010092-uftc8inx 10578 10 the the DT cord-010092-uftc8inx 10578 11 IH-500 IH-500 NNP cord-010092-uftc8inx 10578 12 system system NN cord-010092-uftc8inx 10578 13 provides provide VBZ cord-010092-uftc8inx 10578 14 added add VBN cord-010092-uftc8inx 10578 15 values value NNS cord-010092-uftc8inx 10578 16 compared compare VBN cord-010092-uftc8inx 10578 17 to to IN cord-010092-uftc8inx 10578 18 the the DT cord-010092-uftc8inx 10578 19 sole sole JJ cord-010092-uftc8inx 10578 20 reading reading NN cord-010092-uftc8inx 10578 21 of of IN cord-010092-uftc8inx 10578 22 the the DT cord-010092-uftc8inx 10578 23 titer titer NN cord-010092-uftc8inx 10578 24 . . . cord-010092-uftc8inx 10579 1 For for IN cord-010092-uftc8inx 10579 2 anti anti JJ cord-010092-uftc8inx 10579 3 - - JJ cord-010092-uftc8inx 10579 4 c c JJ cord-010092-uftc8inx 10579 5 immunization immunization NN cord-010092-uftc8inx 10579 6 , , , cord-010092-uftc8inx 10579 7 gel gel NN cord-010092-uftc8inx 10579 8 scores score NNS cord-010092-uftc8inx 10579 9 are be VBP cord-010092-uftc8inx 10579 10 more more RBR cord-010092-uftc8inx 10579 11 discriminant discriminant JJ cord-010092-uftc8inx 10579 12 than than IN cord-010092-uftc8inx 10579 13 tube tube NN cord-010092-uftc8inx 10579 14 ones one NNS cord-010092-uftc8inx 10579 15 and and CC cord-010092-uftc8inx 10579 16 better well RBR cord-010092-uftc8inx 10579 17 correlated correlate VBN cord-010092-uftc8inx 10579 18 to to IN cord-010092-uftc8inx 10579 19 the the DT cord-010092-uftc8inx 10579 20 concentration concentration NN cord-010092-uftc8inx 10579 21 values value NNS cord-010092-uftc8inx 10579 22 established establish VBN cord-010092-uftc8inx 10579 23 by by IN cord-010092-uftc8inx 10579 24 continuous continuous JJ cord-010092-uftc8inx 10579 25 flow flow NN cord-010092-uftc8inx 10579 26 analysis analysis NN cord-010092-uftc8inx 10579 27 . . . cord-010092-uftc8inx 10580 1 The the DT cord-010092-uftc8inx 10580 2 proposed propose VBN cord-010092-uftc8inx 10580 3 score score NN cord-010092-uftc8inx 10580 4 thresholds threshold NNS cord-010092-uftc8inx 10580 5 to to TO cord-010092-uftc8inx 10580 6 trigger trigger VB cord-010092-uftc8inx 10580 7 fetal fetal JJ cord-010092-uftc8inx 10580 8 antenatal antenatal JJ cord-010092-uftc8inx 10580 9 monitoring monitoring NN cord-010092-uftc8inx 10580 10 need need NN cord-010092-uftc8inx 10580 11 , , , cord-010092-uftc8inx 10580 12 however however RB cord-010092-uftc8inx 10580 13 , , , cord-010092-uftc8inx 10580 14 to to TO cord-010092-uftc8inx 10580 15 be be VB cord-010092-uftc8inx 10580 16 confirmed confirm VBN cord-010092-uftc8inx 10580 17 on on IN cord-010092-uftc8inx 10580 18 more more JJR cord-010092-uftc8inx 10580 19 samples sample NNS cord-010092-uftc8inx 10580 20 and and CC cord-010092-uftc8inx 10580 21 to to TO cord-010092-uftc8inx 10580 22 be be VB cord-010092-uftc8inx 10580 23 clinically clinically RB cord-010092-uftc8inx 10580 24 documented document VBN cord-010092-uftc8inx 10580 25 . . . cord-010092-uftc8inx 10581 1 Background background NN cord-010092-uftc8inx 10581 2 : : : cord-010092-uftc8inx 10582 1 HDNF HDNF NNP cord-010092-uftc8inx 10582 2 is be VBZ cord-010092-uftc8inx 10582 3 due due JJ cord-010092-uftc8inx 10582 4 to to IN cord-010092-uftc8inx 10582 5 maternal maternal JJ cord-010092-uftc8inx 10582 6 IgG igg NN cord-010092-uftc8inx 10582 7 alloantibodies alloantibody NNS cord-010092-uftc8inx 10582 8 directed direct VBN cord-010092-uftc8inx 10582 9 against against IN cord-010092-uftc8inx 10582 10 fetal fetal JJ cord-010092-uftc8inx 10582 11 antigens antigen NNS cord-010092-uftc8inx 10582 12 that that WDT cord-010092-uftc8inx 10582 13 cross cross VBP cord-010092-uftc8inx 10582 14 the the DT cord-010092-uftc8inx 10582 15 placenta placenta NN cord-010092-uftc8inx 10582 16 during during IN cord-010092-uftc8inx 10582 17 pregnancy pregnancy NN cord-010092-uftc8inx 10582 18 , , , cord-010092-uftc8inx 10582 19 causing cause VBG cord-010092-uftc8inx 10582 20 hemolysis hemolysis NN cord-010092-uftc8inx 10582 21 in in IN cord-010092-uftc8inx 10582 22 the the DT cord-010092-uftc8inx 10582 23 fetus fetus NN cord-010092-uftc8inx 10582 24 , , , cord-010092-uftc8inx 10582 25 anemia anemia NN cord-010092-uftc8inx 10582 26 that that WDT cord-010092-uftc8inx 10582 27 can can MD cord-010092-uftc8inx 10582 28 lead lead VB cord-010092-uftc8inx 10582 29 to to IN cord-010092-uftc8inx 10582 30 edema edema NN cord-010092-uftc8inx 10582 31 , , , cord-010092-uftc8inx 10582 32 ascites ascites NN cord-010092-uftc8inx 10582 33 , , , cord-010092-uftc8inx 10582 34 hydrops hydrop NNS cord-010092-uftc8inx 10582 35 and and CC cord-010092-uftc8inx 10582 36 , , , cord-010092-uftc8inx 10582 37 in in IN cord-010092-uftc8inx 10582 38 some some DT cord-010092-uftc8inx 10582 39 cases case NNS cord-010092-uftc8inx 10582 40 , , , cord-010092-uftc8inx 10582 41 death death NN cord-010092-uftc8inx 10582 42 . . . cord-010092-uftc8inx 10583 1 The the DT cord-010092-uftc8inx 10583 2 diagnosis diagnosis NN cord-010092-uftc8inx 10583 3 and and CC cord-010092-uftc8inx 10583 4 management management NN cord-010092-uftc8inx 10583 5 of of IN cord-010092-uftc8inx 10583 6 HDNF HDNF NNP cord-010092-uftc8inx 10583 7 is be VBZ cord-010092-uftc8inx 10583 8 based base VBN cord-010092-uftc8inx 10583 9 on on IN cord-010092-uftc8inx 10583 10 maternal maternal JJ cord-010092-uftc8inx 10583 11 screening screening NN cord-010092-uftc8inx 10583 12 , , , cord-010092-uftc8inx 10583 13 and and CC cord-010092-uftc8inx 10583 14 Middle Middle NNP cord-010092-uftc8inx 10583 15 Cerebral Cerebral NNP cord-010092-uftc8inx 10583 16 Artery Artery NNP cord-010092-uftc8inx 10583 17 ( ( -LRB- cord-010092-uftc8inx 10583 18 MCA MCA NNP cord-010092-uftc8inx 10583 19 ) ) -RRB- cord-010092-uftc8inx 10583 20 Doppler Doppler NNP cord-010092-uftc8inx 10583 21 monitoring monitoring NN cord-010092-uftc8inx 10583 22 . . . cord-010092-uftc8inx 10584 1 In in IN cord-010092-uftc8inx 10584 2 severe severe JJ cord-010092-uftc8inx 10584 3 HDNF HDNF NNP cord-010092-uftc8inx 10584 4 intrauterine intrauterine JJ cord-010092-uftc8inx 10584 5 blood blood NN cord-010092-uftc8inx 10584 6 transfusions transfusion NNS cord-010092-uftc8inx 10584 7 ( ( -LRB- cord-010092-uftc8inx 10584 8 IUTs IUTs NNP cord-010092-uftc8inx 10584 9 ) ) -RRB- cord-010092-uftc8inx 10584 10 and and CC cord-010092-uftc8inx 10584 11 or or CC cord-010092-uftc8inx 10584 12 exchange exchange NN cord-010092-uftc8inx 10584 13 transfusion transfusion NN cord-010092-uftc8inx 10584 14 ( ( -LRB- cord-010092-uftc8inx 10584 15 ET ET NNP cord-010092-uftc8inx 10584 16 ) ) -RRB- cord-010092-uftc8inx 10584 17 after after IN cord-010092-uftc8inx 10584 18 birth birth NN cord-010092-uftc8inx 10584 19 are be VBP cord-010092-uftc8inx 10584 20 necessary necessary JJ cord-010092-uftc8inx 10584 21 to to TO cord-010092-uftc8inx 10584 22 correct correct VB cord-010092-uftc8inx 10584 23 anemia anemia NN cord-010092-uftc8inx 10584 24 , , , cord-010092-uftc8inx 10584 25 to to TO cord-010092-uftc8inx 10584 26 prevent prevent VB cord-010092-uftc8inx 10584 27 and and CC cord-010092-uftc8inx 10584 28 treat treat VB cord-010092-uftc8inx 10584 29 fetal fetal JJ cord-010092-uftc8inx 10584 30 hydrops hydrop NNS cord-010092-uftc8inx 10584 31 . . . cord-010092-uftc8inx 10585 1 Aims aim VBZ cord-010092-uftc8inx 10585 2 : : : cord-010092-uftc8inx 10586 1 We -PRON- PRP cord-010092-uftc8inx 10586 2 report report VBP cord-010092-uftc8inx 10586 3 eight eight CD cord-010092-uftc8inx 10586 4 years year NNS cord-010092-uftc8inx 10586 5 of of IN cord-010092-uftc8inx 10586 6 experience experience NN cord-010092-uftc8inx 10586 7 in in IN cord-010092-uftc8inx 10586 8 our -PRON- PRP$ cord-010092-uftc8inx 10586 9 Immunohematology Immunohematology NNP cord-010092-uftc8inx 10586 10 Reference Reference NNP cord-010092-uftc8inx 10586 11 Laboratory Laboratory NNP cord-010092-uftc8inx 10586 12 ( ( -LRB- cord-010092-uftc8inx 10586 13 IRL IRL NNP cord-010092-uftc8inx 10586 14 ) ) -RRB- cord-010092-uftc8inx 10586 15 to to TO cord-010092-uftc8inx 10586 16 highlight highlight VB cord-010092-uftc8inx 10586 17 the the DT cord-010092-uftc8inx 10586 18 importance importance NN cord-010092-uftc8inx 10586 19 of of IN cord-010092-uftc8inx 10586 20 red red JJ cord-010092-uftc8inx 10586 21 cell cell NN cord-010092-uftc8inx 10586 22 antibody antibody NN cord-010092-uftc8inx 10586 23 detection detection NN cord-010092-uftc8inx 10586 24 as as IN cord-010092-uftc8inx 10586 25 a a DT cord-010092-uftc8inx 10586 26 fundamental fundamental JJ cord-010092-uftc8inx 10586 27 parameter parameter NN cord-010092-uftc8inx 10586 28 to to TO cord-010092-uftc8inx 10586 29 identify identify VB cord-010092-uftc8inx 10586 30 pregnancies pregnancy NNS cord-010092-uftc8inx 10586 31 with with IN cord-010092-uftc8inx 10586 32 high high JJ cord-010092-uftc8inx 10586 33 fetal fetal JJ cord-010092-uftc8inx 10586 34 risk risk NN cord-010092-uftc8inx 10586 35 and and CC cord-010092-uftc8inx 10586 36 to to TO cord-010092-uftc8inx 10586 37 drive drive VB cord-010092-uftc8inx 10586 38 a a DT cord-010092-uftc8inx 10586 39 correct correct JJ cord-010092-uftc8inx 10586 40 treatment treatment NN cord-010092-uftc8inx 10586 41 . . . cord-010092-uftc8inx 10587 1 Methods method NNS cord-010092-uftc8inx 10587 2 : : : cord-010092-uftc8inx 10587 3 We -PRON- PRP cord-010092-uftc8inx 10587 4 report report VBP cord-010092-uftc8inx 10587 5 laboratory laboratory NN cord-010092-uftc8inx 10587 6 data datum NNS cord-010092-uftc8inx 10587 7 from from IN cord-010092-uftc8inx 10587 8 250 250 CD cord-010092-uftc8inx 10587 9 pregnant pregnant JJ cord-010092-uftc8inx 10587 10 women woman NNS cord-010092-uftc8inx 10587 11 with with IN cord-010092-uftc8inx 10587 12 a a DT cord-010092-uftc8inx 10587 13 positive positive JJ cord-010092-uftc8inx 10587 14 indirect indirect JJ cord-010092-uftc8inx 10587 15 antiglobulin antiglobulin NN cord-010092-uftc8inx 10587 16 test test NN cord-010092-uftc8inx 10587 17 ( ( -LRB- cord-010092-uftc8inx 10587 18 IAT IAT NNP cord-010092-uftc8inx 10587 19 ) ) -RRB- cord-010092-uftc8inx 10587 20 referred refer VBD cord-010092-uftc8inx 10587 21 to to IN cord-010092-uftc8inx 10587 22 our -PRON- PRP$ cord-010092-uftc8inx 10587 23 IRL IRL NNP cord-010092-uftc8inx 10587 24 from from IN cord-010092-uftc8inx 10587 25 January January NNP cord-010092-uftc8inx 10587 26 2008 2008 CD cord-010092-uftc8inx 10587 27 to to IN cord-010092-uftc8inx 10587 28 December December NNP cord-010092-uftc8inx 10587 29 2016 2016 CD cord-010092-uftc8inx 10587 30 . . . cord-010092-uftc8inx 10588 1 We -PRON- PRP cord-010092-uftc8inx 10588 2 performed perform VBD cord-010092-uftc8inx 10588 3 antibody antibody NN cord-010092-uftc8inx 10588 4 screening screening NN cord-010092-uftc8inx 10588 5 and and CC cord-010092-uftc8inx 10588 6 identification identification NN cord-010092-uftc8inx 10588 7 by by IN cord-010092-uftc8inx 10588 8 indirect indirect JJ cord-010092-uftc8inx 10588 9 antiglobulin antiglobulin NN cord-010092-uftc8inx 10588 10 test test NN cord-010092-uftc8inx 10588 11 ( ( -LRB- cord-010092-uftc8inx 10588 12 IAT IAT NNP cord-010092-uftc8inx 10588 13 ) ) -RRB- cord-010092-uftc8inx 10588 14 in in IN cord-010092-uftc8inx 10588 15 microcolumn microcolumn NN cord-010092-uftc8inx 10588 16 method method NN cord-010092-uftc8inx 10588 17 with with IN cord-010092-uftc8inx 10588 18 BioVue BioVue NNP cord-010092-uftc8inx 10588 19 System System NNP cord-010092-uftc8inx 10588 20 ( ( -LRB- cord-010092-uftc8inx 10588 21 Ortho Ortho NNP cord-010092-uftc8inx 10588 22 - - HYPH cord-010092-uftc8inx 10588 23 Clinical Clinical NNP cord-010092-uftc8inx 10588 24 Diagnostics Diagnostics NNPS cord-010092-uftc8inx 10588 25 , , , cord-010092-uftc8inx 10588 26 Raritan Raritan NNP cord-010092-uftc8inx 10588 27 , , , cord-010092-uftc8inx 10588 28 USA USA NNP cord-010092-uftc8inx 10588 29 ) ) -RRB- cord-010092-uftc8inx 10588 30 , , , cord-010092-uftc8inx 10588 31 and and CC cord-010092-uftc8inx 10588 32 the the DT cord-010092-uftc8inx 10588 33 title title NN cord-010092-uftc8inx 10588 34 of of IN cord-010092-uftc8inx 10588 35 antibodies antibody NNS cord-010092-uftc8inx 10588 36 in in IN cord-010092-uftc8inx 10588 37 IAT IAT NNP cord-010092-uftc8inx 10588 38 by by IN cord-010092-uftc8inx 10588 39 tube tube NN cord-010092-uftc8inx 10588 40 method method NN cord-010092-uftc8inx 10588 41 without without IN cord-010092-uftc8inx 10588 42 additive additive NN cord-010092-uftc8inx 10588 43 . . . cord-010092-uftc8inx 10589 1 Follow follow VB cord-010092-uftc8inx 10589 2 - - HYPH cord-010092-uftc8inx 10589 3 up up NN cord-010092-uftc8inx 10589 4 tests test NNS cord-010092-uftc8inx 10589 5 were be VBD cord-010092-uftc8inx 10589 6 also also RB cord-010092-uftc8inx 10589 7 performed perform VBN cord-010092-uftc8inx 10589 8 in in IN cord-010092-uftc8inx 10589 9 the the DT cord-010092-uftc8inx 10589 10 presence presence NN cord-010092-uftc8inx 10589 11 of of IN cord-010092-uftc8inx 10589 12 significant significant JJ cord-010092-uftc8inx 10589 13 red red JJ cord-010092-uftc8inx 10589 14 cell cell NN cord-010092-uftc8inx 10589 15 antibodies antibody NNS cord-010092-uftc8inx 10589 16 in in IN cord-010092-uftc8inx 10589 17 order order NN cord-010092-uftc8inx 10589 18 to to TO cord-010092-uftc8inx 10589 19 check check VB cord-010092-uftc8inx 10589 20 antibody antibody NN cord-010092-uftc8inx 10589 21 title title NN cord-010092-uftc8inx 10589 22 and and CC cord-010092-uftc8inx 10589 23 begin begin VB cord-010092-uftc8inx 10589 24 clinical clinical JJ cord-010092-uftc8inx 10589 25 monitoring monitoring NN cord-010092-uftc8inx 10589 26 . . . cord-010092-uftc8inx 10590 1 Threshold threshold NN cord-010092-uftc8inx 10590 2 values value NNS cord-010092-uftc8inx 10590 3 were be VBD cord-010092-uftc8inx 10590 4 ≥ ≥ CD cord-010092-uftc8inx 10590 5 1:8 1:8 CD cord-010092-uftc8inx 10590 6 for for IN cord-010092-uftc8inx 10590 7 anti anti JJ cord-010092-uftc8inx 10590 8 Kell Kell NNP cord-010092-uftc8inx 10590 9 antibodies antibody NNS cord-010092-uftc8inx 10590 10 and and CC cord-010092-uftc8inx 10590 11 ≥ ≥ CD cord-010092-uftc8inx 10590 12 1:32 1:32 CD cord-010092-uftc8inx 10590 13 for for IN cord-010092-uftc8inx 10590 14 other other JJ cord-010092-uftc8inx 10590 15 specificities specificity NNS cord-010092-uftc8inx 10590 16 . . . cord-010092-uftc8inx 10591 1 Results result NNS cord-010092-uftc8inx 10591 2 : : : cord-010092-uftc8inx 10592 1 Out out IN cord-010092-uftc8inx 10592 2 of of IN cord-010092-uftc8inx 10592 3 250 250 CD cord-010092-uftc8inx 10592 4 women woman NNS cord-010092-uftc8inx 10592 5 , , , cord-010092-uftc8inx 10592 6 143 143 CD cord-010092-uftc8inx 10592 7 ( ( -LRB- cord-010092-uftc8inx 10592 8 57.2 57.2 CD cord-010092-uftc8inx 10592 9 % % NN cord-010092-uftc8inx 10592 10 ) ) -RRB- cord-010092-uftc8inx 10592 11 displayed display VBD cord-010092-uftc8inx 10592 12 clinically clinically RB cord-010092-uftc8inx 10592 13 significant significant JJ cord-010092-uftc8inx 10592 14 antibodies antibody NNS cord-010092-uftc8inx 10592 15 , , , cord-010092-uftc8inx 10592 16 92 92 CD cord-010092-uftc8inx 10592 17 ( ( -LRB- cord-010092-uftc8inx 10592 18 36.8 36.8 CD cord-010092-uftc8inx 10592 19 % % NN cord-010092-uftc8inx 10592 20 ) ) -RRB- cord-010092-uftc8inx 10592 21 clinically clinically RB cord-010092-uftc8inx 10592 22 insignificant insignificant JJ cord-010092-uftc8inx 10592 23 antibodies antibody NNS cord-010092-uftc8inx 10592 24 and and CC cord-010092-uftc8inx 10592 25 15 15 CD cord-010092-uftc8inx 10592 26 ( ( -LRB- cord-010092-uftc8inx 10592 27 6 6 CD cord-010092-uftc8inx 10592 28 % % NN cord-010092-uftc8inx 10592 29 ) ) -RRB- cord-010092-uftc8inx 10592 30 natural natural JJ cord-010092-uftc8inx 10592 31 antibodies antibody NNS cord-010092-uftc8inx 10592 32 of of IN cord-010092-uftc8inx 10592 33 different different JJ cord-010092-uftc8inx 10592 34 specificities specificity NNS cord-010092-uftc8inx 10592 35 . . . cord-010092-uftc8inx 10593 1 Among among IN cord-010092-uftc8inx 10593 2 women woman NNS cord-010092-uftc8inx 10593 3 with with IN cord-010092-uftc8inx 10593 4 clinically clinically RB cord-010092-uftc8inx 10593 5 significant significant JJ cord-010092-uftc8inx 10593 6 antibodies antibody NNS cord-010092-uftc8inx 10594 1 the the DT cord-010092-uftc8inx 10594 2 most most RBS cord-010092-uftc8inx 10594 3 frequent frequent JJ cord-010092-uftc8inx 10594 4 was be VBD cord-010092-uftc8inx 10594 5 anti anti JJ cord-010092-uftc8inx 10594 6 - - JJ cord-010092-uftc8inx 10594 7 D d JJ cord-010092-uftc8inx 10594 8 ( ( -LRB- cord-010092-uftc8inx 10594 9 16.8 16.8 CD cord-010092-uftc8inx 10594 10 % % NN cord-010092-uftc8inx 10594 11 ) ) -RRB- cord-010092-uftc8inx 10594 12 also also RB cord-010092-uftc8inx 10594 13 in in IN cord-010092-uftc8inx 10594 14 combination combination NN cord-010092-uftc8inx 10594 15 with with IN cord-010092-uftc8inx 10594 16 other other JJ cord-010092-uftc8inx 10594 17 Rh Rh NNP cord-010092-uftc8inx 10594 18 antibodies antibody NNS cord-010092-uftc8inx 10594 19 ( ( -LRB- cord-010092-uftc8inx 10594 20 8.8 8.8 CD cord-010092-uftc8inx 10594 21 % % NN cord-010092-uftc8inx 10594 22 ) ) -RRB- cord-010092-uftc8inx 10594 23 , , , cord-010092-uftc8inx 10594 24 while while IN cord-010092-uftc8inx 10594 25 anti anti JJ cord-010092-uftc8inx 10594 26 - - NNP cord-010092-uftc8inx 10594 27 K K NNP cord-010092-uftc8inx 10594 28 accounted account VBD cord-010092-uftc8inx 10594 29 for for IN cord-010092-uftc8inx 10594 30 10 10 CD cord-010092-uftc8inx 10594 31 % % NN cord-010092-uftc8inx 10594 32 , , , cord-010092-uftc8inx 10594 33 anti anti JJ cord-010092-uftc8inx 10594 34 - - NN cord-010092-uftc8inx 10594 35 E e JJ cord-010092-uftc8inx 10594 36 for for IN cord-010092-uftc8inx 10594 37 10 10 CD cord-010092-uftc8inx 10594 38 % % NN cord-010092-uftc8inx 10594 39 and and CC cord-010092-uftc8inx 10594 40 antibodies antibody NNS cord-010092-uftc8inx 10594 41 against against IN cord-010092-uftc8inx 10594 42 high high JJ cord-010092-uftc8inx 10594 43 - - HYPH cord-010092-uftc8inx 10594 44 incidence incidence NN cord-010092-uftc8inx 10594 45 antigens antigen NNS cord-010092-uftc8inx 10594 46 for for IN cord-010092-uftc8inx 10594 47 2.4 2.4 CD cord-010092-uftc8inx 10594 48 % % NN cord-010092-uftc8inx 10594 49 . . . cord-010092-uftc8inx 10595 1 Anti Anti NNP cord-010092-uftc8inx 10595 2 - - NNP cord-010092-uftc8inx 10595 3 M M NNP cord-010092-uftc8inx 10595 4 and and CC cord-010092-uftc8inx 10595 5 anti anti NNP cord-010092-uftc8inx 10595 6 - - NNP cord-010092-uftc8inx 10595 7 Le Le NNP cord-010092-uftc8inx 10595 8 a a DT cord-010092-uftc8inx 10595 9 antibodies antibody NNS cord-010092-uftc8inx 10595 10 were be VBD cord-010092-uftc8inx 10595 11 also also RB cord-010092-uftc8inx 10595 12 found find VBN cord-010092-uftc8inx 10595 13 ( ( -LRB- cord-010092-uftc8inx 10595 14 16.8 16.8 CD cord-010092-uftc8inx 10595 15 % % NN cord-010092-uftc8inx 10595 16 and and CC cord-010092-uftc8inx 10595 17 8 8 CD cord-010092-uftc8inx 10595 18 % % NN cord-010092-uftc8inx 10595 19 respectively respectively RB cord-010092-uftc8inx 10595 20 ) ) -RRB- cord-010092-uftc8inx 10595 21 but but CC cord-010092-uftc8inx 10595 22 they -PRON- PRP cord-010092-uftc8inx 10595 23 were be VBD cord-010092-uftc8inx 10595 24 not not RB cord-010092-uftc8inx 10595 25 clinically clinically RB cord-010092-uftc8inx 10595 26 significant significant JJ cord-010092-uftc8inx 10595 27 . . . cord-010092-uftc8inx 10596 1 Among among IN cord-010092-uftc8inx 10596 2 143 143 CD cord-010092-uftc8inx 10596 3 women woman NNS cord-010092-uftc8inx 10596 4 with with IN cord-010092-uftc8inx 10596 5 clinically clinically RB cord-010092-uftc8inx 10596 6 relevant relevant JJ cord-010092-uftc8inx 10596 7 antibodies antibody NNS cord-010092-uftc8inx 10596 8 , , , cord-010092-uftc8inx 10596 9 37 37 CD cord-010092-uftc8inx 10596 10 showed show VBD cord-010092-uftc8inx 10596 11 a a DT cord-010092-uftc8inx 10596 12 critic critic JJ cord-010092-uftc8inx 10596 13 antibody antibody NN cord-010092-uftc8inx 10596 14 title title NN cord-010092-uftc8inx 10596 15 and and CC cord-010092-uftc8inx 10596 16 they -PRON- PRP cord-010092-uftc8inx 10596 17 underwent undergo VBD cord-010092-uftc8inx 10596 18 gynecological gynecological JJ cord-010092-uftc8inx 10596 19 and and CC cord-010092-uftc8inx 10596 20 obstetric obstetric JJ cord-010092-uftc8inx 10596 21 monitoring monitoring NN cord-010092-uftc8inx 10596 22 . . . cord-010092-uftc8inx 10597 1 21 21 CD cord-010092-uftc8inx 10597 2 fetuses fetus NNS cord-010092-uftc8inx 10597 3 resulted result VBD cord-010092-uftc8inx 10597 4 affected affect VBN cord-010092-uftc8inx 10597 5 by by IN cord-010092-uftc8inx 10597 6 HDFN HDFN NNP cord-010092-uftc8inx 10597 7 , , , cord-010092-uftc8inx 10597 8 displaying display VBG cord-010092-uftc8inx 10597 9 anti anti JJ cord-010092-uftc8inx 10597 10 - - JJ cord-010092-uftc8inx 10597 11 D d JJ cord-010092-uftc8inx 10597 12 in in IN cord-010092-uftc8inx 10597 13 16 16 CD cord-010092-uftc8inx 10597 14 cases case NNS cord-010092-uftc8inx 10597 15 and and CC cord-010092-uftc8inx 10597 16 anti anti JJ cord-010092-uftc8inx 10597 17 - - NNP cord-010092-uftc8inx 10597 18 Kell Kell NNP cord-010092-uftc8inx 10597 19 in in IN cord-010092-uftc8inx 10597 20 5 5 CD cord-010092-uftc8inx 10597 21 . . . cord-010092-uftc8inx 10598 1 11 11 CD cord-010092-uftc8inx 10598 2 fetuses fetus NNS cord-010092-uftc8inx 10598 3 with with IN cord-010092-uftc8inx 10598 4 severe severe JJ cord-010092-uftc8inx 10598 5 HDFN HDFN NNP cord-010092-uftc8inx 10598 6 ( ( -LRB- cord-010092-uftc8inx 10598 7 anti anti JJ cord-010092-uftc8inx 10598 8 - - JJ cord-010092-uftc8inx 10598 9 D d JJ cord-010092-uftc8inx 10598 10 in in IN cord-010092-uftc8inx 10598 11 7 7 CD cord-010092-uftc8inx 10598 12 and and CC cord-010092-uftc8inx 10598 13 anti anti JJ cord-010092-uftc8inx 10598 14 - - NNP cord-010092-uftc8inx 10598 15 Kell Kell NNP cord-010092-uftc8inx 10598 16 in in IN cord-010092-uftc8inx 10598 17 4 4 CD cord-010092-uftc8inx 10598 18 ) ) -RRB- cord-010092-uftc8inx 10598 19 required require VBN cord-010092-uftc8inx 10598 20 IUTs iut NNS cord-010092-uftc8inx 10598 21 , , , cord-010092-uftc8inx 10598 22 2 2 CD cord-010092-uftc8inx 10598 23 were be VBD cord-010092-uftc8inx 10598 24 treated treat VBN cord-010092-uftc8inx 10598 25 with with IN cord-010092-uftc8inx 10598 26 ET ET NNP cord-010092-uftc8inx 10598 27 , , , cord-010092-uftc8inx 10598 28 8 8 CD cord-010092-uftc8inx 10598 29 received receive VBD cord-010092-uftc8inx 10598 30 red red JJ cord-010092-uftc8inx 10598 31 blood blood NN cord-010092-uftc8inx 10598 32 cells cell NNS cord-010092-uftc8inx 10598 33 units unit NNS cord-010092-uftc8inx 10598 34 at at IN cord-010092-uftc8inx 10598 35 birth birth NN cord-010092-uftc8inx 10598 36 . . . cord-010092-uftc8inx 10599 1 Summary Summary NNP cord-010092-uftc8inx 10599 2 / / SYM cord-010092-uftc8inx 10599 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 10599 4 : : : cord-010092-uftc8inx 10600 1 The the DT cord-010092-uftc8inx 10600 2 mother mother NN cord-010092-uftc8inx 10600 3 screening screening NN cord-010092-uftc8inx 10600 4 program program NN cord-010092-uftc8inx 10600 5 led lead VBD cord-010092-uftc8inx 10600 6 to to IN cord-010092-uftc8inx 10600 7 important important JJ cord-010092-uftc8inx 10600 8 improvements improvement NNS cord-010092-uftc8inx 10600 9 in in IN cord-010092-uftc8inx 10600 10 the the DT cord-010092-uftc8inx 10600 11 outcomes outcome NNS cord-010092-uftc8inx 10600 12 of of IN cord-010092-uftc8inx 10600 13 HDFN HDFN NNP cord-010092-uftc8inx 10600 14 . . . cord-010092-uftc8inx 10601 1 The the DT cord-010092-uftc8inx 10601 2 identification identification NN cord-010092-uftc8inx 10601 3 of of IN cord-010092-uftc8inx 10601 4 women woman NNS cord-010092-uftc8inx 10601 5 with with IN cord-010092-uftc8inx 10601 6 clinically clinically RB cord-010092-uftc8inx 10601 7 significant significant JJ cord-010092-uftc8inx 10601 8 antibodies antibody NNS cord-010092-uftc8inx 10601 9 allowed allow VBD cord-010092-uftc8inx 10601 10 an an DT cord-010092-uftc8inx 10601 11 appropriate appropriate JJ cord-010092-uftc8inx 10601 12 monitoring monitoring NN cord-010092-uftc8inx 10601 13 program program NN cord-010092-uftc8inx 10601 14 and and CC cord-010092-uftc8inx 10601 15 therapy therapy NN cord-010092-uftc8inx 10601 16 . . . cord-010092-uftc8inx 10602 1 Background background NN cord-010092-uftc8inx 10602 2 : : : cord-010092-uftc8inx 10603 1 The the DT cord-010092-uftc8inx 10603 2 hemolytic hemolytic JJ cord-010092-uftc8inx 10603 3 disease disease NN cord-010092-uftc8inx 10603 4 of of IN cord-010092-uftc8inx 10603 5 the the DT cord-010092-uftc8inx 10603 6 fetus fetus NN cord-010092-uftc8inx 10603 7 and and CC cord-010092-uftc8inx 10603 8 newborn newborn JJ cord-010092-uftc8inx 10603 9 ( ( -LRB- cord-010092-uftc8inx 10603 10 HDFN HDFN NNP cord-010092-uftc8inx 10603 11 ) ) -RRB- cord-010092-uftc8inx 10603 12 is be VBZ cord-010092-uftc8inx 10603 13 a a DT cord-010092-uftc8inx 10603 14 severe severe JJ cord-010092-uftc8inx 10603 15 disease disease NN cord-010092-uftc8inx 10603 16 , , , cord-010092-uftc8inx 10603 17 resulting result VBG cord-010092-uftc8inx 10603 18 from from IN cord-010092-uftc8inx 10603 19 maternal maternal JJ cord-010092-uftc8inx 10603 20 erythrocyte erythrocyte NN cord-010092-uftc8inx 10603 21 alloantibodies alloantibody NNS cord-010092-uftc8inx 10603 22 directed direct VBN cord-010092-uftc8inx 10603 23 against against IN cord-010092-uftc8inx 10603 24 fetal fetal JJ cord-010092-uftc8inx 10603 25 erythrocytes erythrocyte NNS cord-010092-uftc8inx 10603 26 . . . cord-010092-uftc8inx 10604 1 Alloimmunization alloimmunization NN cord-010092-uftc8inx 10604 2 in in IN cord-010092-uftc8inx 10604 3 pregnant pregnant JJ cord-010092-uftc8inx 10604 4 women woman NNS cord-010092-uftc8inx 10604 5 has have VBZ cord-010092-uftc8inx 10604 6 been be VBN cord-010092-uftc8inx 10604 7 found find VBN cord-010092-uftc8inx 10604 8 to to TO cord-010092-uftc8inx 10604 9 range range VB cord-010092-uftc8inx 10604 10 from from IN cord-010092-uftc8inx 10604 11 0,4 0,4 CD cord-010092-uftc8inx 10604 12 % % NN cord-010092-uftc8inx 10604 13 to to IN cord-010092-uftc8inx 10604 14 2,7 2,7 CD cord-010092-uftc8inx 10604 15 % % NN cord-010092-uftc8inx 10604 16 worldwide worldwide RB cord-010092-uftc8inx 10604 17 . . . cord-010092-uftc8inx 10605 1 There there EX cord-010092-uftc8inx 10605 2 are be VBP cord-010092-uftc8inx 10605 3 over over IN cord-010092-uftc8inx 10605 4 400 400 CD cord-010092-uftc8inx 10605 5 erythrocyte erythrocyte NN cord-010092-uftc8inx 10605 6 surface surface NN cord-010092-uftc8inx 10605 7 antigens antigen NNS cord-010092-uftc8inx 10605 8 , , , cord-010092-uftc8inx 10605 9 of of IN cord-010092-uftc8inx 10605 10 which which WDT cord-010092-uftc8inx 10605 11 more more JJR cord-010092-uftc8inx 10605 12 than than IN cord-010092-uftc8inx 10605 13 43 43 CD cord-010092-uftc8inx 10605 14 have have VBP cord-010092-uftc8inx 10605 15 been be VBN cord-010092-uftc8inx 10605 16 reported report VBN cord-010092-uftc8inx 10605 17 to to TO cord-010092-uftc8inx 10605 18 be be VB cord-010092-uftc8inx 10605 19 associated associate VBN cord-010092-uftc8inx 10605 20 with with IN cord-010092-uftc8inx 10605 21 HDFN HDFN NNP cord-010092-uftc8inx 10605 22 . . . cord-010092-uftc8inx 10606 1 Although although IN cord-010092-uftc8inx 10606 2 anti anti JJ cord-010092-uftc8inx 10606 3 - - JJ cord-010092-uftc8inx 10606 4 Rhesus rhesus JJ cord-010092-uftc8inx 10606 5 D d NN cord-010092-uftc8inx 10606 6 was be VBD cord-010092-uftc8inx 10606 7 once once RB cord-010092-uftc8inx 10606 8 the the DT cord-010092-uftc8inx 10606 9 major major JJ cord-010092-uftc8inx 10606 10 etiology etiology NN cord-010092-uftc8inx 10606 11 of of IN cord-010092-uftc8inx 10606 12 HDFN HDFN NNP cord-010092-uftc8inx 10606 13 , , , cord-010092-uftc8inx 10606 14 the the DT cord-010092-uftc8inx 10606 15 universal universal JJ cord-010092-uftc8inx 10606 16 introduction introduction NN cord-010092-uftc8inx 10606 17 of of IN cord-010092-uftc8inx 10606 18 antenatal antenatal JJ cord-010092-uftc8inx 10606 19 and and CC cord-010092-uftc8inx 10606 20 postpartum postpartum NN cord-010092-uftc8inx 10606 21 Rh Rh NNP cord-010092-uftc8inx 10606 22 immunoglobulin immunoglobulin NN cord-010092-uftc8inx 10606 23 has have VBZ cord-010092-uftc8inx 10606 24 resulted result VBN cord-010092-uftc8inx 10606 25 in in IN cord-010092-uftc8inx 10606 26 a a DT cord-010092-uftc8inx 10606 27 marked marked JJ cord-010092-uftc8inx 10606 28 decrease decrease NN cord-010092-uftc8inx 10606 29 in in IN cord-010092-uftc8inx 10606 30 the the DT cord-010092-uftc8inx 10606 31 prevalence prevalence NN cord-010092-uftc8inx 10606 32 of of IN cord-010092-uftc8inx 10606 33 alloimmunization alloimmunization NN cord-010092-uftc8inx 10606 34 to to IN cord-010092-uftc8inx 10606 35 the the DT cord-010092-uftc8inx 10606 36 RhD RhD NNP cord-010092-uftc8inx 10606 37 antigen antigen NN cord-010092-uftc8inx 10606 38 in in IN cord-010092-uftc8inx 10606 39 pregnancy pregnancy NN cord-010092-uftc8inx 10606 40 . . . cord-010092-uftc8inx 10607 1 Consequently consequently RB cord-010092-uftc8inx 10607 2 , , , cord-010092-uftc8inx 10607 3 alloantibodies alloantibody NNS cord-010092-uftc8inx 10607 4 other other JJ cord-010092-uftc8inx 10607 5 than than IN cord-010092-uftc8inx 10607 6 anti anti JJ cord-010092-uftc8inx 10607 7 - - JJ cord-010092-uftc8inx 10607 8 D d JJ cord-010092-uftc8inx 10607 9 emerged emerge VBD cord-010092-uftc8inx 10607 10 as as IN cord-010092-uftc8inx 10607 11 an an DT cord-010092-uftc8inx 10607 12 important important JJ cord-010092-uftc8inx 10607 13 cause cause NN cord-010092-uftc8inx 10607 14 of of IN cord-010092-uftc8inx 10607 15 severe severe JJ cord-010092-uftc8inx 10607 16 HDNF HDNF NNP cord-010092-uftc8inx 10607 17 , , , cord-010092-uftc8inx 10607 18 in in IN cord-010092-uftc8inx 10607 19 particular particular JJ cord-010092-uftc8inx 10607 20 anti anti JJ cord-010092-uftc8inx 10607 21 - - JJ cord-010092-uftc8inx 10607 22 K k JJ cord-010092-uftc8inx 10607 23 and and CC cord-010092-uftc8inx 10607 24 anti anti JJ cord-010092-uftc8inx 10607 25 - - NN cord-010092-uftc8inx 10607 26 c c JJ cord-010092-uftc8inx 10607 27 . . . cord-010092-uftc8inx 10608 1 However however RB cord-010092-uftc8inx 10608 2 , , , cord-010092-uftc8inx 10608 3 there there EX cord-010092-uftc8inx 10608 4 are be VBP cord-010092-uftc8inx 10608 5 other other JJ cord-010092-uftc8inx 10608 6 antigens antigen NNS cord-010092-uftc8inx 10608 7 that that WDT cord-010092-uftc8inx 10608 8 have have VBP cord-010092-uftc8inx 10608 9 also also RB cord-010092-uftc8inx 10608 10 been be VBN cord-010092-uftc8inx 10608 11 found find VBN cord-010092-uftc8inx 10608 12 to to TO cord-010092-uftc8inx 10608 13 be be VB cord-010092-uftc8inx 10608 14 associated associate VBN cord-010092-uftc8inx 10608 15 with with IN cord-010092-uftc8inx 10608 16 HDFN HDFN NNP cord-010092-uftc8inx 10608 17 . . . cord-010092-uftc8inx 10609 1 Aims aim VBZ cord-010092-uftc8inx 10609 2 : : : cord-010092-uftc8inx 10610 1 Retrospective retrospective JJ cord-010092-uftc8inx 10610 2 identification identification NN cord-010092-uftc8inx 10610 3 of of IN cord-010092-uftc8inx 10610 4 erythrocyte erythrocyte NN cord-010092-uftc8inx 10610 5 antibodies antibody NNS cord-010092-uftc8inx 10610 6 in in IN cord-010092-uftc8inx 10610 7 pregnant pregnant JJ cord-010092-uftc8inx 10610 8 women woman NNS cord-010092-uftc8inx 10610 9 in in IN cord-010092-uftc8inx 10610 10 Hospital Hospital NNP cord-010092-uftc8inx 10610 11 de de NNP cord-010092-uftc8inx 10610 12 Braga Braga NNP cord-010092-uftc8inx 10610 13 in in IN cord-010092-uftc8inx 10610 14 2016 2016 CD cord-010092-uftc8inx 10610 15 and and CC cord-010092-uftc8inx 10610 16 2017 2017 CD cord-010092-uftc8inx 10610 17 . . . cord-010092-uftc8inx 10611 1 Methods method NNS cord-010092-uftc8inx 10611 2 : : : cord-010092-uftc8inx 10612 1 This this DT cord-010092-uftc8inx 10612 2 study study NN cord-010092-uftc8inx 10612 3 was be VBD cord-010092-uftc8inx 10612 4 planned plan VBN cord-010092-uftc8inx 10612 5 to to TO cord-010092-uftc8inx 10612 6 assess assess VB cord-010092-uftc8inx 10612 7 the the DT cord-010092-uftc8inx 10612 8 prevalence prevalence NN cord-010092-uftc8inx 10612 9 of of IN cord-010092-uftc8inx 10612 10 erythrocyte erythrocyte NN cord-010092-uftc8inx 10612 11 antibodies antibody NNS cord-010092-uftc8inx 10612 12 responsible responsible JJ cord-010092-uftc8inx 10612 13 for for IN cord-010092-uftc8inx 10612 14 alloimmunization alloimmunization NN cord-010092-uftc8inx 10612 15 , , , cord-010092-uftc8inx 10612 16 excluding exclude VBG cord-010092-uftc8inx 10612 17 ABO ABO NNP cord-010092-uftc8inx 10612 18 - - HYPH cord-010092-uftc8inx 10612 19 immunizations immunization NNS cord-010092-uftc8inx 10612 20 , , , cord-010092-uftc8inx 10612 21 in in IN cord-010092-uftc8inx 10612 22 pregnant pregnant JJ cord-010092-uftc8inx 10612 23 women woman NNS cord-010092-uftc8inx 10612 24 attending attend VBG cord-010092-uftc8inx 10612 25 the the DT cord-010092-uftc8inx 10612 26 antenatal antenatal JJ cord-010092-uftc8inx 10612 27 clinics clinic NNS cord-010092-uftc8inx 10612 28 of of IN cord-010092-uftc8inx 10612 29 Hospital Hospital NNP cord-010092-uftc8inx 10612 30 Braga Braga NNP cord-010092-uftc8inx 10612 31 during during IN cord-010092-uftc8inx 10612 32 2 2 CD cord-010092-uftc8inx 10612 33 years year NNS cord-010092-uftc8inx 10612 34 , , , cord-010092-uftc8inx 10612 35 from from IN cord-010092-uftc8inx 10612 36 January January NNP cord-010092-uftc8inx 10612 37 2016 2016 CD cord-010092-uftc8inx 10612 38 to to IN cord-010092-uftc8inx 10612 39 December December NNP cord-010092-uftc8inx 10612 40 2017 2017 CD cord-010092-uftc8inx 10612 41 . . . cord-010092-uftc8inx 10613 1 In in IN cord-010092-uftc8inx 10613 2 this this DT cord-010092-uftc8inx 10613 3 study study NN cord-010092-uftc8inx 10613 4 , , , cord-010092-uftc8inx 10613 5 we -PRON- PRP cord-010092-uftc8inx 10613 6 retrospectively retrospectively RB cord-010092-uftc8inx 10613 7 evaluated evaluate VBD cord-010092-uftc8inx 10613 8 the the DT cord-010092-uftc8inx 10613 9 erythrocyte erythrocyte NN cord-010092-uftc8inx 10613 10 antibody antibody NN cord-010092-uftc8inx 10613 11 screening screening NN cord-010092-uftc8inx 10613 12 results result NNS cord-010092-uftc8inx 10613 13 of of IN cord-010092-uftc8inx 10613 14 pregnant pregnant JJ cord-010092-uftc8inx 10613 15 women woman NNS cord-010092-uftc8inx 10613 16 . . . cord-010092-uftc8inx 10614 1 Women woman NNS cord-010092-uftc8inx 10614 2 with with IN cord-010092-uftc8inx 10614 3 positive positive JJ cord-010092-uftc8inx 10614 4 erythrocyte erythrocyte NN cord-010092-uftc8inx 10614 5 antibody antibody NN cord-010092-uftc8inx 10614 6 screening screening NN cord-010092-uftc8inx 10614 7 also also RB cord-010092-uftc8inx 10614 8 underwent undergo VBD cord-010092-uftc8inx 10614 9 identification identification NN cord-010092-uftc8inx 10614 10 with with IN cord-010092-uftc8inx 10614 11 gel gel NN cord-010092-uftc8inx 10614 12 card card NN cord-010092-uftc8inx 10614 13 system system NN cord-010092-uftc8inx 10614 14 following follow VBG cord-010092-uftc8inx 10614 15 the the DT cord-010092-uftc8inx 10614 16 manufacturer manufacturer NN cord-010092-uftc8inx 10614 17 's 's POS cord-010092-uftc8inx 10614 18 instructions instruction NNS cord-010092-uftc8inx 10614 19 ( ( -LRB- cord-010092-uftc8inx 10614 20 DiaMed DiaMed NNP cord-010092-uftc8inx 10614 21 â â NNP cord-010092-uftc8inx 10614 22 ) ) -RRB- cord-010092-uftc8inx 10614 23 . . . cord-010092-uftc8inx 10615 1 The the DT cord-010092-uftc8inx 10615 2 outcomes outcome NNS cord-010092-uftc8inx 10615 3 of of IN cord-010092-uftc8inx 10615 4 infants infant NNS cord-010092-uftc8inx 10615 5 , , , cord-010092-uftc8inx 10615 6 whose whose WP$ cord-010092-uftc8inx 10615 7 mother mother NN cord-010092-uftc8inx 10615 8 's 's POS cord-010092-uftc8inx 10615 9 indirect indirect JJ cord-010092-uftc8inx 10615 10 antiglobulin antiglobulin NN cord-010092-uftc8inx 10615 11 tests test NNS cord-010092-uftc8inx 10615 12 were be VBD cord-010092-uftc8inx 10615 13 found find VBN cord-010092-uftc8inx 10615 14 to to TO cord-010092-uftc8inx 10615 15 be be VB cord-010092-uftc8inx 10615 16 positive positive JJ cord-010092-uftc8inx 10615 17 , , , cord-010092-uftc8inx 10615 18 were be VBD cord-010092-uftc8inx 10615 19 examined examine VBN cord-010092-uftc8inx 10615 20 . . . cord-010092-uftc8inx 10616 1 Direct direct JJ cord-010092-uftc8inx 10616 2 antiglobulin antiglobulin NN cord-010092-uftc8inx 10616 3 tests test NNS cord-010092-uftc8inx 10616 4 , , , cord-010092-uftc8inx 10616 5 jaundice jaundice NN cord-010092-uftc8inx 10616 6 and and CC cord-010092-uftc8inx 10616 7 phototherapy phototherapy NN cord-010092-uftc8inx 10616 8 history history NN cord-010092-uftc8inx 10616 9 , , , cord-010092-uftc8inx 10616 10 transfusion transfusion NN cord-010092-uftc8inx 10616 11 and and CC cord-010092-uftc8inx 10616 12 mortality mortality NN cord-010092-uftc8inx 10616 13 of of IN cord-010092-uftc8inx 10616 14 the the DT cord-010092-uftc8inx 10616 15 newborns newborn NNS cord-010092-uftc8inx 10616 16 were be VBD cord-010092-uftc8inx 10616 17 recorded record VBN cord-010092-uftc8inx 10616 18 . . . cord-010092-uftc8inx 10617 1 Results result NNS cord-010092-uftc8inx 10617 2 : : : cord-010092-uftc8inx 10618 1 During during IN cord-010092-uftc8inx 10618 2 the the DT cord-010092-uftc8inx 10618 3 study study NN cord-010092-uftc8inx 10618 4 period period NN cord-010092-uftc8inx 10618 5 , , , cord-010092-uftc8inx 10618 6 5982 5982 CD cord-010092-uftc8inx 10618 7 pregnant pregnant JJ cord-010092-uftc8inx 10618 8 women woman NNS cord-010092-uftc8inx 10618 9 were be VBD cord-010092-uftc8inx 10618 10 attended attend VBN cord-010092-uftc8inx 10618 11 in in IN cord-010092-uftc8inx 10618 12 Hospital Hospital NNP cord-010092-uftc8inx 10618 13 de de NNP cord-010092-uftc8inx 10618 14 Braga Braga NNP cord-010092-uftc8inx 10618 15 . . . cord-010092-uftc8inx 10619 1 The the DT cord-010092-uftc8inx 10619 2 laboratory laboratory NN cord-010092-uftc8inx 10619 3 registered register VBD cord-010092-uftc8inx 10619 4 100 100 CD cord-010092-uftc8inx 10619 5 positive positive JJ cord-010092-uftc8inx 10619 6 erythrocyte erythrocyte NN cord-010092-uftc8inx 10619 7 antibody antibody NN cord-010092-uftc8inx 10619 8 screening screening NN cord-010092-uftc8inx 10619 9 tests test NNS cord-010092-uftc8inx 10619 10 . . . cord-010092-uftc8inx 10620 1 The the DT cord-010092-uftc8inx 10620 2 prevalence prevalence NN cord-010092-uftc8inx 10620 3 of of IN cord-010092-uftc8inx 10620 4 positive positive JJ cord-010092-uftc8inx 10620 5 erythrocyte erythrocyte NN cord-010092-uftc8inx 10620 6 antibody antibody NN cord-010092-uftc8inx 10620 7 screening screening NN cord-010092-uftc8inx 10620 8 was be VBD cord-010092-uftc8inx 10620 9 1,7 1,7 CD cord-010092-uftc8inx 10620 10 % % NN cord-010092-uftc8inx 10620 11 . . . cord-010092-uftc8inx 10621 1 Anti Anti NNP cord-010092-uftc8inx 10621 2 - - NNP cord-010092-uftc8inx 10621 3 D D NNP cord-010092-uftc8inx 10621 4 was be VBD cord-010092-uftc8inx 10621 5 the the DT cord-010092-uftc8inx 10621 6 most most RBS cord-010092-uftc8inx 10621 7 common common JJ cord-010092-uftc8inx 10621 8 antibody antibody NN cord-010092-uftc8inx 10621 9 found find VBD cord-010092-uftc8inx 10621 10 ( ( -LRB- cord-010092-uftc8inx 10621 11 58,5 58,5 CD cord-010092-uftc8inx 10621 12 % % NN cord-010092-uftc8inx 10621 13 ) ) -RRB- cord-010092-uftc8inx 10621 14 . . . cord-010092-uftc8inx 10622 1 Anti anti JJ cord-010092-uftc8inx 10622 2 - - JJ cord-010092-uftc8inx 10622 3 D d JJ cord-010092-uftc8inx 10622 4 prophylaxis prophylaxis NN cord-010092-uftc8inx 10622 5 given give VBN cord-010092-uftc8inx 10622 6 during during IN cord-010092-uftc8inx 10622 7 pregnancy pregnancy NN cord-010092-uftc8inx 10622 8 was be VBD cord-010092-uftc8inx 10622 9 responsible responsible JJ cord-010092-uftc8inx 10622 10 for for IN cord-010092-uftc8inx 10622 11 51 51 CD cord-010092-uftc8inx 10622 12 of of IN cord-010092-uftc8inx 10622 13 62 62 CD cord-010092-uftc8inx 10622 14 cases case NNS cord-010092-uftc8inx 10622 15 and and CC cord-010092-uftc8inx 10622 16 maternal maternal JJ cord-010092-uftc8inx 10622 17 antibody antibody NN cord-010092-uftc8inx 10622 18 titer titer NN cord-010092-uftc8inx 10622 19 levels level NNS cord-010092-uftc8inx 10622 20 did do VBD cord-010092-uftc8inx 10622 21 not not RB cord-010092-uftc8inx 10622 22 exceed exceed VB cord-010092-uftc8inx 10622 23 8 8 CD cord-010092-uftc8inx 10622 24 among among IN cord-010092-uftc8inx 10622 25 these these DT cord-010092-uftc8inx 10622 26 cases case NNS cord-010092-uftc8inx 10622 27 . . . cord-010092-uftc8inx 10623 1 The the DT cord-010092-uftc8inx 10623 2 prevalence prevalence NN cord-010092-uftc8inx 10623 3 of of IN cord-010092-uftc8inx 10623 4 non non JJ cord-010092-uftc8inx 10623 5 - - JJ cord-010092-uftc8inx 10623 6 RhD rhd JJ cord-010092-uftc8inx 10623 7 immunization immunization NN cord-010092-uftc8inx 10623 8 was be VBD cord-010092-uftc8inx 10623 9 33 33 CD cord-010092-uftc8inx 10623 10 % % NN cord-010092-uftc8inx 10623 11 . . . cord-010092-uftc8inx 10624 1 Anti anti JJ cord-010092-uftc8inx 10624 2 - - NN cord-010092-uftc8inx 10624 3 E e JJ cord-010092-uftc8inx 10624 4 ( ( -LRB- cord-010092-uftc8inx 10624 5 9,4 9,4 CD cord-010092-uftc8inx 10624 6 % % NN cord-010092-uftc8inx 10624 7 ) ) -RRB- cord-010092-uftc8inx 10624 8 was be VBD cord-010092-uftc8inx 10624 9 the the DT cord-010092-uftc8inx 10624 10 most most RBS cord-010092-uftc8inx 10624 11 frequent frequent JJ cord-010092-uftc8inx 10624 12 alloantibody alloantibody NN cord-010092-uftc8inx 10624 13 other other JJ cord-010092-uftc8inx 10624 14 than than IN cord-010092-uftc8inx 10624 15 anti anti JJ cord-010092-uftc8inx 10624 16 - - JJ cord-010092-uftc8inx 10624 17 D d JJ cord-010092-uftc8inx 10624 18 followed follow VBN cord-010092-uftc8inx 10624 19 by by IN cord-010092-uftc8inx 10624 20 anti anti JJ cord-010092-uftc8inx 10624 21 - - JJ cord-010092-uftc8inx 10624 22 M m JJ cord-010092-uftc8inx 10624 23 ( ( -LRB- cord-010092-uftc8inx 10624 24 5,7 5,7 CD cord-010092-uftc8inx 10624 25 % % NN cord-010092-uftc8inx 10624 26 ) ) -RRB- cord-010092-uftc8inx 10624 27 and and CC cord-010092-uftc8inx 10624 28 anti anti JJ cord-010092-uftc8inx 10624 29 - - JJ cord-010092-uftc8inx 10624 30 C c JJ cord-010092-uftc8inx 10624 31 ( ( -LRB- cord-010092-uftc8inx 10624 32 4,7 4,7 CD cord-010092-uftc8inx 10624 33 % % NN cord-010092-uftc8inx 10624 34 ) ) -RRB- cord-010092-uftc8inx 10624 35 . . . cord-010092-uftc8inx 10625 1 Multiple multiple JJ cord-010092-uftc8inx 10625 2 maternal maternal JJ cord-010092-uftc8inx 10625 3 antibodies antibody NNS cord-010092-uftc8inx 10625 4 were be VBD cord-010092-uftc8inx 10625 5 found find VBN cord-010092-uftc8inx 10625 6 in in IN cord-010092-uftc8inx 10625 7 5 5 CD cord-010092-uftc8inx 10625 8 pregnant pregnant JJ cord-010092-uftc8inx 10625 9 women woman NNS cord-010092-uftc8inx 10625 10 . . . cord-010092-uftc8inx 10626 1 Four four CD cord-010092-uftc8inx 10626 2 women woman NNS cord-010092-uftc8inx 10626 3 had have VBD cord-010092-uftc8inx 10626 4 2 2 CD cord-010092-uftc8inx 10626 5 types type NNS cord-010092-uftc8inx 10626 6 of of IN cord-010092-uftc8inx 10626 7 alloantibodies alloantibody NNS cord-010092-uftc8inx 10626 8 : : : cord-010092-uftc8inx 10626 9 anti anti JJ cord-010092-uftc8inx 10626 10 - - NN cord-010092-uftc8inx 10626 11 c c JJ cord-010092-uftc8inx 10626 12 and and CC cord-010092-uftc8inx 10626 13 anti anti JJ cord-010092-uftc8inx 10626 14 - - JJ cord-010092-uftc8inx 10626 15 E e JJ cord-010092-uftc8inx 10626 16 ; ; : cord-010092-uftc8inx 10626 17 anti anti JJ cord-010092-uftc8inx 10626 18 - - JJ cord-010092-uftc8inx 10626 19 C c JJ cord-010092-uftc8inx 10626 20 and and CC cord-010092-uftc8inx 10626 21 anti anti JJ cord-010092-uftc8inx 10626 22 - - JJ cord-010092-uftc8inx 10626 23 D d JJ cord-010092-uftc8inx 10626 24 ; ; : cord-010092-uftc8inx 10626 25 anti anti JJ cord-010092-uftc8inx 10626 26 - - JJ cord-010092-uftc8inx 10626 27 K k JJ cord-010092-uftc8inx 10626 28 and and CC cord-010092-uftc8inx 10626 29 anti anti JJ cord-010092-uftc8inx 10626 30 - - JJ cord-010092-uftc8inx 10626 31 Cw cw JJ cord-010092-uftc8inx 10626 32 ; ; : cord-010092-uftc8inx 10626 33 anti anti JJ cord-010092-uftc8inx 10626 34 - - JJ cord-010092-uftc8inx 10626 35 E E NNS cord-010092-uftc8inx 10626 36 and and CC cord-010092-uftc8inx 10626 37 a a DT cord-010092-uftc8inx 10626 38 non non JJ cord-010092-uftc8inx 10626 39 - - JJ cord-010092-uftc8inx 10626 40 identified identified JJ cord-010092-uftc8inx 10626 41 antibody antibody NN cord-010092-uftc8inx 10626 42 . . . cord-010092-uftc8inx 10627 1 One one CD cord-010092-uftc8inx 10627 2 pregnant pregnant JJ cord-010092-uftc8inx 10627 3 had have VBD cord-010092-uftc8inx 10627 4 3 3 CD cord-010092-uftc8inx 10627 5 types type NNS cord-010092-uftc8inx 10627 6 of of IN cord-010092-uftc8inx 10627 7 alloantibodies alloantibody NNS cord-010092-uftc8inx 10627 8 : : : cord-010092-uftc8inx 10627 9 anti anti JJ cord-010092-uftc8inx 10627 10 - - JJ cord-010092-uftc8inx 10627 11 D d JJ cord-010092-uftc8inx 10627 12 , , , cord-010092-uftc8inx 10627 13 anti anti JJ cord-010092-uftc8inx 10627 14 - - NNP cord-010092-uftc8inx 10627 15 C c JJ cord-010092-uftc8inx 10627 16 and and CC cord-010092-uftc8inx 10627 17 anti anti JJ cord-010092-uftc8inx 10627 18 - - NNP cord-010092-uftc8inx 10627 19 E. E. NNP cord-010092-uftc8inx 10627 20 Of of IN cord-010092-uftc8inx 10627 21 all all DT cord-010092-uftc8inx 10627 22 cases case NNS cord-010092-uftc8inx 10627 23 of of IN cord-010092-uftc8inx 10627 24 newborns newborn NNS cord-010092-uftc8inx 10627 25 whose whose WP$ cord-010092-uftc8inx 10627 26 mothers mother NNS cord-010092-uftc8inx 10627 27 had have VBD cord-010092-uftc8inx 10627 28 a a DT cord-010092-uftc8inx 10627 29 positive positive JJ cord-010092-uftc8inx 10627 30 antibody antibody NN cord-010092-uftc8inx 10627 31 screen screen NN cord-010092-uftc8inx 10627 32 tests test NNS cord-010092-uftc8inx 10627 33 , , , cord-010092-uftc8inx 10627 34 icterus icterus NN cord-010092-uftc8inx 10627 35 occurred occur VBD cord-010092-uftc8inx 10627 36 in in IN cord-010092-uftc8inx 10627 37 45 45 CD cord-010092-uftc8inx 10627 38 % % NN cord-010092-uftc8inx 10627 39 of of IN cord-010092-uftc8inx 10627 40 them -PRON- PRP cord-010092-uftc8inx 10627 41 and and CC cord-010092-uftc8inx 10627 42 phototherapy phototherapy NN cord-010092-uftc8inx 10627 43 was be VBD cord-010092-uftc8inx 10627 44 given give VBN cord-010092-uftc8inx 10627 45 in in IN cord-010092-uftc8inx 10627 46 14 14 CD cord-010092-uftc8inx 10627 47 % % NN cord-010092-uftc8inx 10627 48 . . . cord-010092-uftc8inx 10628 1 Summary Summary NNP cord-010092-uftc8inx 10628 2 / / SYM cord-010092-uftc8inx 10628 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 10628 4 : : : cord-010092-uftc8inx 10629 1 The the DT cord-010092-uftc8inx 10629 2 prevalence prevalence NN cord-010092-uftc8inx 10629 3 of of IN cord-010092-uftc8inx 10629 4 positive positive JJ cord-010092-uftc8inx 10629 5 erythrocyte erythrocyte NN cord-010092-uftc8inx 10629 6 antibody antibody NN cord-010092-uftc8inx 10629 7 screening screening NN cord-010092-uftc8inx 10629 8 in in IN cord-010092-uftc8inx 10629 9 Hospital Hospital NNP cord-010092-uftc8inx 10629 10 de de NNP cord-010092-uftc8inx 10629 11 Braga Braga NNP cord-010092-uftc8inx 10629 12 was be VBD cord-010092-uftc8inx 10629 13 1,7 1,7 CD cord-010092-uftc8inx 10629 14 % % NN cord-010092-uftc8inx 10629 15 . . . cord-010092-uftc8inx 10630 1 The the DT cord-010092-uftc8inx 10630 2 erythrocyte erythrocyte NN cord-010092-uftc8inx 10630 3 antibody antibody NN cord-010092-uftc8inx 10630 4 screening screening NN cord-010092-uftc8inx 10630 5 showed show VBD cord-010092-uftc8inx 10630 6 that that IN cord-010092-uftc8inx 10630 7 anti anti JJ cord-010092-uftc8inx 10630 8 - - JJ cord-010092-uftc8inx 10630 9 D D NNP cord-010092-uftc8inx 10630 10 was be VBD cord-010092-uftc8inx 10630 11 the the DT cord-010092-uftc8inx 10630 12 most most RBS cord-010092-uftc8inx 10630 13 common common JJ cord-010092-uftc8inx 10630 14 antibody antibody NN cord-010092-uftc8inx 10630 15 found find VBD cord-010092-uftc8inx 10630 16 ( ( -LRB- cord-010092-uftc8inx 10630 17 58,5 58,5 CD cord-010092-uftc8inx 10630 18 % % NN cord-010092-uftc8inx 10630 19 ) ) -RRB- cord-010092-uftc8inx 10630 20 in in IN cord-010092-uftc8inx 10630 21 most most JJS cord-010092-uftc8inx 10630 22 of of IN cord-010092-uftc8inx 10630 23 the the DT cord-010092-uftc8inx 10630 24 cases case NNS cord-010092-uftc8inx 10630 25 because because IN cord-010092-uftc8inx 10630 26 of of IN cord-010092-uftc8inx 10630 27 anti anti JJ cord-010092-uftc8inx 10630 28 - - JJ cord-010092-uftc8inx 10630 29 D d JJ cord-010092-uftc8inx 10630 30 prophylaxis prophylaxis NN cord-010092-uftc8inx 10630 31 . . . cord-010092-uftc8inx 10631 1 The the DT cord-010092-uftc8inx 10631 2 prevalence prevalence NN cord-010092-uftc8inx 10631 3 of of IN cord-010092-uftc8inx 10631 4 non non JJ cord-010092-uftc8inx 10631 5 - - JJ cord-010092-uftc8inx 10631 6 RhD rhd JJ cord-010092-uftc8inx 10631 7 immunization immunization NN cord-010092-uftc8inx 10631 8 was be VBD cord-010092-uftc8inx 10631 9 33 33 CD cord-010092-uftc8inx 10631 10 % % NN cord-010092-uftc8inx 10631 11 . . . cord-010092-uftc8inx 10632 1 The the DT cord-010092-uftc8inx 10632 2 other other JJ cord-010092-uftc8inx 10632 3 most most RBS cord-010092-uftc8inx 10632 4 frequent frequent JJ cord-010092-uftc8inx 10632 5 alloantibodies alloantibody NNS cord-010092-uftc8inx 10632 6 were be VBD cord-010092-uftc8inx 10632 7 anti anti JJ cord-010092-uftc8inx 10632 8 - - JJ cord-010092-uftc8inx 10632 9 E e JJ cord-010092-uftc8inx 10632 10 ( ( -LRB- cord-010092-uftc8inx 10632 11 9,4 9,4 CD cord-010092-uftc8inx 10632 12 % % NN cord-010092-uftc8inx 10632 13 ) ) -RRB- cord-010092-uftc8inx 10632 14 , , , cord-010092-uftc8inx 10632 15 anti anti NNP cord-010092-uftc8inx 10632 16 - - NNP cord-010092-uftc8inx 10632 17 M m JJ cord-010092-uftc8inx 10632 18 ( ( -LRB- cord-010092-uftc8inx 10632 19 5,7 5,7 CD cord-010092-uftc8inx 10632 20 % % NN cord-010092-uftc8inx 10632 21 ) ) -RRB- cord-010092-uftc8inx 10632 22 and and CC cord-010092-uftc8inx 10632 23 anti anti JJ cord-010092-uftc8inx 10632 24 - - JJ cord-010092-uftc8inx 10632 25 C c JJ cord-010092-uftc8inx 10632 26 ( ( -LRB- cord-010092-uftc8inx 10632 27 4,7 4,7 CD cord-010092-uftc8inx 10632 28 % % NN cord-010092-uftc8inx 10632 29 ) ) -RRB- cord-010092-uftc8inx 10632 30 . . . cord-010092-uftc8inx 10633 1 An an DT cord-010092-uftc8inx 10633 2 increasing increase VBG cord-010092-uftc8inx 10633 3 prevalence prevalence NN cord-010092-uftc8inx 10633 4 of of IN cord-010092-uftc8inx 10633 5 non non JJ cord-010092-uftc8inx 10633 6 - - JJ cord-010092-uftc8inx 10633 7 anti anti JJ cord-010092-uftc8inx 10633 8 - - JJ cord-010092-uftc8inx 10633 9 D d JJ cord-010092-uftc8inx 10633 10 alloimmunization alloimmunization NN cord-010092-uftc8inx 10633 11 was be VBD cord-010092-uftc8inx 10633 12 found find VBN cord-010092-uftc8inx 10633 13 and and CC cord-010092-uftc8inx 10633 14 there there EX cord-010092-uftc8inx 10633 15 are be VBP cord-010092-uftc8inx 10633 16 currently currently RB cord-010092-uftc8inx 10633 17 no no DT cord-010092-uftc8inx 10633 18 preventive preventive JJ cord-010092-uftc8inx 10633 19 strategies strategy NNS cord-010092-uftc8inx 10633 20 . . . cord-010092-uftc8inx 10634 1 In in IN cord-010092-uftc8inx 10634 2 contrast contrast NN cord-010092-uftc8inx 10634 3 to to IN cord-010092-uftc8inx 10634 4 RhD RhD NNP cord-010092-uftc8inx 10634 5 alloimmunization alloimmunization NNP cord-010092-uftc8inx 10634 6 , , , cord-010092-uftc8inx 10634 7 the the DT cord-010092-uftc8inx 10634 8 main main JJ cord-010092-uftc8inx 10634 9 risk risk NN cord-010092-uftc8inx 10634 10 factor factor NN cord-010092-uftc8inx 10634 11 for for IN cord-010092-uftc8inx 10634 12 non non JJ cord-010092-uftc8inx 10634 13 - - JJ cord-010092-uftc8inx 10634 14 anti anti JJ cord-010092-uftc8inx 10634 15 - - JJ cord-010092-uftc8inx 10634 16 D d JJ cord-010092-uftc8inx 10634 17 alloimmunization alloimmunization NN cord-010092-uftc8inx 10634 18 is be VBZ cord-010092-uftc8inx 10634 19 a a DT cord-010092-uftc8inx 10634 20 previous previous JJ cord-010092-uftc8inx 10634 21 transfusion transfusion NN cord-010092-uftc8inx 10634 22 therapy therapy NN cord-010092-uftc8inx 10634 23 . . . cord-010092-uftc8inx 10635 1 Thus thus RB cord-010092-uftc8inx 10635 2 , , , cord-010092-uftc8inx 10635 3 it -PRON- PRP cord-010092-uftc8inx 10635 4 is be VBZ cord-010092-uftc8inx 10635 5 important important JJ cord-010092-uftc8inx 10635 6 to to TO cord-010092-uftc8inx 10635 7 minimize minimize VB cord-010092-uftc8inx 10635 8 the the DT cord-010092-uftc8inx 10635 9 exposure exposure NN cord-010092-uftc8inx 10635 10 of of IN cord-010092-uftc8inx 10635 11 women woman NNS cord-010092-uftc8inx 10635 12 to to IN cord-010092-uftc8inx 10635 13 incompatible incompatible JJ cord-010092-uftc8inx 10635 14 erythrocyte erythrocyte NN cord-010092-uftc8inx 10635 15 antigens antigen NNS cord-010092-uftc8inx 10635 16 through through IN cord-010092-uftc8inx 10635 17 unnecessary unnecessary JJ cord-010092-uftc8inx 10635 18 transfusions transfusion NNS cord-010092-uftc8inx 10635 19 when when WRB cord-010092-uftc8inx 10635 20 possible possible JJ cord-010092-uftc8inx 10635 21 . . . cord-010092-uftc8inx 10636 1 Background background NN cord-010092-uftc8inx 10636 2 : : : cord-010092-uftc8inx 10637 1 The the DT cord-010092-uftc8inx 10637 2 MNS MNS NNP cord-010092-uftc8inx 10637 3 blood blood NN cord-010092-uftc8inx 10637 4 group group NN cord-010092-uftc8inx 10637 5 system system NN cord-010092-uftc8inx 10637 6 is be VBZ cord-010092-uftc8inx 10637 7 one one CD cord-010092-uftc8inx 10637 8 of of IN cord-010092-uftc8inx 10637 9 the the DT cord-010092-uftc8inx 10637 10 most most RBS cord-010092-uftc8inx 10637 11 complex complex JJ cord-010092-uftc8inx 10637 12 blood blood NN cord-010092-uftc8inx 10637 13 group group NN cord-010092-uftc8inx 10637 14 systems system NNS cord-010092-uftc8inx 10637 15 . . . cord-010092-uftc8inx 10638 1 Although although IN cord-010092-uftc8inx 10638 2 alloanti alloanti NNP cord-010092-uftc8inx 10638 3 - - HYPH cord-010092-uftc8inx 10638 4 M M NNP cord-010092-uftc8inx 10638 5 is be VBZ cord-010092-uftc8inx 10638 6 a a DT cord-010092-uftc8inx 10638 7 common common JJ cord-010092-uftc8inx 10638 8 antibody antibody NN cord-010092-uftc8inx 10638 9 observed observe VBN cord-010092-uftc8inx 10638 10 in in IN cord-010092-uftc8inx 10638 11 pregnant pregnant JJ cord-010092-uftc8inx 10638 12 women woman NNS cord-010092-uftc8inx 10638 13 and and CC cord-010092-uftc8inx 10638 14 could could MD cord-010092-uftc8inx 10638 15 also also RB cord-010092-uftc8inx 10638 16 be be VB cord-010092-uftc8inx 10638 17 found find VBN cord-010092-uftc8inx 10638 18 in in IN cord-010092-uftc8inx 10638 19 the the DT cord-010092-uftc8inx 10638 20 serum serum NN cord-010092-uftc8inx 10638 21 of of IN cord-010092-uftc8inx 10638 22 individuals individual NNS cord-010092-uftc8inx 10638 23 who who WP cord-010092-uftc8inx 10638 24 have have VBP cord-010092-uftc8inx 10638 25 not not RB cord-010092-uftc8inx 10638 26 been be VBN cord-010092-uftc8inx 10638 27 exposed expose VBN cord-010092-uftc8inx 10638 28 to to IN cord-010092-uftc8inx 10638 29 M M NNP cord-010092-uftc8inx 10638 30 positive positive JJ cord-010092-uftc8inx 10638 31 erythrocytes erythrocyte NNS cord-010092-uftc8inx 10638 32 , , , cord-010092-uftc8inx 10638 33 it -PRON- PRP cord-010092-uftc8inx 10638 34 is be VBZ cord-010092-uftc8inx 10638 35 rarely rarely RB cord-010092-uftc8inx 10638 36 clinically clinically RB cord-010092-uftc8inx 10638 37 significant significant JJ cord-010092-uftc8inx 10638 38 and and CC cord-010092-uftc8inx 10638 39 has have VBZ cord-010092-uftc8inx 10638 40 been be VBN cord-010092-uftc8inx 10638 41 regarded regard VBN cord-010092-uftc8inx 10638 42 as as IN cord-010092-uftc8inx 10638 43 an an DT cord-010092-uftc8inx 10638 44 unimportant unimportant JJ cord-010092-uftc8inx 10638 45 antibody antibody NN cord-010092-uftc8inx 10638 46 to to TO cord-010092-uftc8inx 10638 47 cause cause VB cord-010092-uftc8inx 10638 48 hemolytic hemolytic JJ cord-010092-uftc8inx 10638 49 disease disease NN cord-010092-uftc8inx 10638 50 of of IN cord-010092-uftc8inx 10638 51 the the DT cord-010092-uftc8inx 10638 52 fetus fetus NN cord-010092-uftc8inx 10638 53 and and CC cord-010092-uftc8inx 10638 54 newborn newborn JJ cord-010092-uftc8inx 10638 55 ( ( -LRB- cord-010092-uftc8inx 10638 56 HDFN HDFN NNP cord-010092-uftc8inx 10638 57 ) ) -RRB- cord-010092-uftc8inx 10638 58 , , , cord-010092-uftc8inx 10638 59 especially especially RB cord-010092-uftc8inx 10638 60 in in IN cord-010092-uftc8inx 10638 61 Caucasian caucasian JJ cord-010092-uftc8inx 10638 62 and and CC cord-010092-uftc8inx 10638 63 black black JJ cord-010092-uftc8inx 10638 64 ethnic ethnic JJ cord-010092-uftc8inx 10638 65 groups group NNS cord-010092-uftc8inx 10638 66 , , , cord-010092-uftc8inx 10638 67 for for IN cord-010092-uftc8inx 10638 68 a a DT cord-010092-uftc8inx 10638 69 long long JJ cord-010092-uftc8inx 10638 70 time time NN cord-010092-uftc8inx 10638 71 . . . cord-010092-uftc8inx 10639 1 However however RB cord-010092-uftc8inx 10639 2 , , , cord-010092-uftc8inx 10639 3 an an DT cord-010092-uftc8inx 10639 4 increasing increase VBG cord-010092-uftc8inx 10639 5 number number NN cord-010092-uftc8inx 10639 6 of of IN cord-010092-uftc8inx 10639 7 cases case NNS cord-010092-uftc8inx 10639 8 of of IN cord-010092-uftc8inx 10639 9 severe severe JJ cord-010092-uftc8inx 10639 10 HDFN HDFN NNP cord-010092-uftc8inx 10639 11 resulting result VBG cord-010092-uftc8inx 10639 12 in in IN cord-010092-uftc8inx 10639 13 fetal fetal JJ cord-010092-uftc8inx 10639 14 hydrops hydrop NNS cord-010092-uftc8inx 10639 15 and and CC cord-010092-uftc8inx 10639 16 recurrent recurrent JJ cord-010092-uftc8inx 10639 17 abortion abortion NN cord-010092-uftc8inx 10639 18 caused cause VBN cord-010092-uftc8inx 10639 19 by by IN cord-010092-uftc8inx 10639 20 alloanti alloanti NNP cord-010092-uftc8inx 10639 21 - - HYPH cord-010092-uftc8inx 10639 22 M M NNP cord-010092-uftc8inx 10639 23 have have VBP cord-010092-uftc8inx 10639 24 been be VBN cord-010092-uftc8inx 10639 25 reported report VBN cord-010092-uftc8inx 10639 26 mainly mainly RB cord-010092-uftc8inx 10639 27 in in IN cord-010092-uftc8inx 10639 28 the the DT cord-010092-uftc8inx 10639 29 Asian asian JJ cord-010092-uftc8inx 10639 30 population population NN cord-010092-uftc8inx 10639 31 , , , cord-010092-uftc8inx 10639 32 especially especially RB cord-010092-uftc8inx 10639 33 in in IN cord-010092-uftc8inx 10639 34 the the DT cord-010092-uftc8inx 10639 35 Japanese japanese JJ cord-010092-uftc8inx 10639 36 and and CC cord-010092-uftc8inx 10639 37 Chinese chinese JJ cord-010092-uftc8inx 10639 38 populations population NNS cord-010092-uftc8inx 10639 39 . . . cord-010092-uftc8inx 10640 1 Aims aim VBZ cord-010092-uftc8inx 10640 2 : : : cord-010092-uftc8inx 10640 3 To to TO cord-010092-uftc8inx 10640 4 summarize summarize VB cord-010092-uftc8inx 10640 5 the the DT cord-010092-uftc8inx 10640 6 characters character NNS cord-010092-uftc8inx 10640 7 of of IN cord-010092-uftc8inx 10640 8 serological serological JJ cord-010092-uftc8inx 10640 9 testing testing NN cord-010092-uftc8inx 10640 10 in in IN cord-010092-uftc8inx 10640 11 preterm preterm JJR cord-010092-uftc8inx 10640 12 twins twin NNS cord-010092-uftc8inx 10640 13 newborns newborn NNS cord-010092-uftc8inx 10640 14 suffered suffer VBD cord-010092-uftc8inx 10640 15 with with IN cord-010092-uftc8inx 10640 16 severe severe JJ cord-010092-uftc8inx 10640 17 HDFN HDFN NNP cord-010092-uftc8inx 10640 18 . . . cord-010092-uftc8inx 10641 1 Methods method NNS cord-010092-uftc8inx 10641 2 : : : cord-010092-uftc8inx 10642 1 The the DT cord-010092-uftc8inx 10642 2 blood blood NN cord-010092-uftc8inx 10642 3 sample sample NN cord-010092-uftc8inx 10642 4 of of IN cord-010092-uftc8inx 10642 5 two two CD cord-010092-uftc8inx 10642 6 newborns newborn NNS cord-010092-uftc8inx 10642 7 with with IN cord-010092-uftc8inx 10642 8 severe severe JJ cord-010092-uftc8inx 10642 9 HDFN HDFN NNP cord-010092-uftc8inx 10642 10 and and CC cord-010092-uftc8inx 10642 11 the the DT cord-010092-uftc8inx 10642 12 mother mother NN cord-010092-uftc8inx 10642 13 , , , cord-010092-uftc8inx 10642 14 who who WP cord-010092-uftc8inx 10642 15 had have VBD cord-010092-uftc8inx 10642 16 the the DT cord-010092-uftc8inx 10642 17 history history NN cord-010092-uftc8inx 10642 18 with with IN cord-010092-uftc8inx 10642 19 three three CD cord-010092-uftc8inx 10642 20 hydrops hydrop NNS cord-010092-uftc8inx 10642 21 fetus fetus NN cord-010092-uftc8inx 10642 22 , , , cord-010092-uftc8inx 10642 23 were be VBD cord-010092-uftc8inx 10642 24 collected collect VBN cord-010092-uftc8inx 10642 25 . . . cord-010092-uftc8inx 10643 1 ABO ABO NNP cord-010092-uftc8inx 10643 2 , , , cord-010092-uftc8inx 10643 3 RhD RhD NNP cord-010092-uftc8inx 10643 4 , , , cord-010092-uftc8inx 10643 5 RhCE RhCE NNP cord-010092-uftc8inx 10643 6 , , , cord-010092-uftc8inx 10643 7 and and CC cord-010092-uftc8inx 10643 8 MN MN NNP cord-010092-uftc8inx 10643 9 blood blood NN cord-010092-uftc8inx 10643 10 group group NN cord-010092-uftc8inx 10643 11 typing typing NN cord-010092-uftc8inx 10643 12 of of IN cord-010092-uftc8inx 10643 13 the the DT cord-010092-uftc8inx 10643 14 twins twin NNS cord-010092-uftc8inx 10643 15 newborn newborn JJ cord-010092-uftc8inx 10643 16 and and CC cord-010092-uftc8inx 10643 17 their -PRON- PRP$ cord-010092-uftc8inx 10643 18 mother mother NN cord-010092-uftc8inx 10643 19 were be VBD cord-010092-uftc8inx 10643 20 performed perform VBN cord-010092-uftc8inx 10643 21 in in IN cord-010092-uftc8inx 10643 22 saline saline NN cord-010092-uftc8inx 10643 23 with with IN cord-010092-uftc8inx 10643 24 tube tube NN cord-010092-uftc8inx 10643 25 or or CC cord-010092-uftc8inx 10643 26 gel gel NN cord-010092-uftc8inx 10643 27 card card NN cord-010092-uftc8inx 10643 28 . . . cord-010092-uftc8inx 10644 1 Direct direct JJ cord-010092-uftc8inx 10644 2 agglutination agglutination NN cord-010092-uftc8inx 10644 3 test test NN cord-010092-uftc8inx 10644 4 ( ( -LRB- cord-010092-uftc8inx 10644 5 DAT DAT NNP cord-010092-uftc8inx 10644 6 ) ) -RRB- cord-010092-uftc8inx 10644 7 , , , cord-010092-uftc8inx 10644 8 elution elution NN cord-010092-uftc8inx 10644 9 test test NN cord-010092-uftc8inx 10644 10 , , , cord-010092-uftc8inx 10644 11 antibody antibody NN cord-010092-uftc8inx 10644 12 specificity specificity NN cord-010092-uftc8inx 10644 13 identification identification NN cord-010092-uftc8inx 10644 14 and and CC cord-010092-uftc8inx 10644 15 antibody antibody NN cord-010092-uftc8inx 10644 16 titer titer NN cord-010092-uftc8inx 10644 17 detection detection NN cord-010092-uftc8inx 10644 18 were be VBD cord-010092-uftc8inx 10644 19 conducted conduct VBN cord-010092-uftc8inx 10644 20 by by IN cord-010092-uftc8inx 10644 21 IAT IAT NNP cord-010092-uftc8inx 10644 22 method method NN cord-010092-uftc8inx 10644 23 in in IN cord-010092-uftc8inx 10644 24 gel gel NN cord-010092-uftc8inx 10644 25 card card NN cord-010092-uftc8inx 10644 26 . . . cord-010092-uftc8inx 10645 1 Results result NNS cord-010092-uftc8inx 10645 2 : : : cord-010092-uftc8inx 10645 3 O o UH cord-010092-uftc8inx 10645 4 , , , cord-010092-uftc8inx 10645 5 RhD(+ RhD(+ NNP cord-010092-uftc8inx 10645 6 ) ) -RRB- cord-010092-uftc8inx 10645 7 , , , cord-010092-uftc8inx 10645 8 and and CC cord-010092-uftc8inx 10645 9 CcEe CcEe NNP cord-010092-uftc8inx 10645 10 blood blood NN cord-010092-uftc8inx 10645 11 groups group NNS cord-010092-uftc8inx 10645 12 were be VBD cord-010092-uftc8inx 10645 13 identified identify VBN cord-010092-uftc8inx 10645 14 both both CC cord-010092-uftc8inx 10645 15 in in IN cord-010092-uftc8inx 10645 16 the the DT cord-010092-uftc8inx 10645 17 mother mother NN cord-010092-uftc8inx 10645 18 and and CC cord-010092-uftc8inx 10645 19 the the DT cord-010092-uftc8inx 10645 20 twins twin NNS cord-010092-uftc8inx 10645 21 newborn newborn JJ cord-010092-uftc8inx 10645 22 . . . cord-010092-uftc8inx 10646 1 Background background NN cord-010092-uftc8inx 10646 2 : : : cord-010092-uftc8inx 10647 1 In in IN cord-010092-uftc8inx 10647 2 France France NNP cord-010092-uftc8inx 10647 3 , , , cord-010092-uftc8inx 10647 4 since since IN cord-010092-uftc8inx 10647 5 May May NNP cord-010092-uftc8inx 10647 6 2018 2018 CD cord-010092-uftc8inx 10647 7 , , , cord-010092-uftc8inx 10647 8 the the DT cord-010092-uftc8inx 10647 9 legislation legislation NN cord-010092-uftc8inx 10647 10 does do VBZ cord-010092-uftc8inx 10647 11 not not RB cord-010092-uftc8inx 10647 12 promote promote VB cord-010092-uftc8inx 10647 13 anymore anymore RB cord-010092-uftc8inx 10647 14 the the DT cord-010092-uftc8inx 10647 15 use use NN cord-010092-uftc8inx 10647 16 of of IN cord-010092-uftc8inx 10647 17 the the DT cord-010092-uftc8inx 10647 18 reference reference NN cord-010092-uftc8inx 10647 19 tube tube NN cord-010092-uftc8inx 10647 20 method method NN cord-010092-uftc8inx 10647 21 for for IN cord-010092-uftc8inx 10647 22 titration titration NN cord-010092-uftc8inx 10647 23 of of IN cord-010092-uftc8inx 10647 24 anti anti JJ cord-010092-uftc8inx 10647 25 - - JJ cord-010092-uftc8inx 10647 26 red red JJ cord-010092-uftc8inx 10647 27 blood blood NN cord-010092-uftc8inx 10647 28 cells cell NNS cord-010092-uftc8inx 10647 29 antibodies antibody NNS cord-010092-uftc8inx 10647 30 . . . cord-010092-uftc8inx 10648 1 This this DT cord-010092-uftc8inx 10648 2 opened open VBD cord-010092-uftc8inx 10648 3 the the DT cord-010092-uftc8inx 10648 4 way way NN cord-010092-uftc8inx 10648 5 to to IN cord-010092-uftc8inx 10648 6 the the DT cord-010092-uftc8inx 10648 7 use use NN cord-010092-uftc8inx 10648 8 of of IN cord-010092-uftc8inx 10648 9 newly newly RB cord-010092-uftc8inx 10648 10 developed develop VBN cord-010092-uftc8inx 10648 11 automated automate VBN cord-010092-uftc8inx 10648 12 anti anti JJ cord-010092-uftc8inx 10648 13 - - JJ cord-010092-uftc8inx 10648 14 red red JJ cord-010092-uftc8inx 10648 15 blood blood NN cord-010092-uftc8inx 10648 16 cells cell NNS cord-010092-uftc8inx 10648 17 antibodies antibody NNS cord-010092-uftc8inx 10648 18 quantitation quantitation NN cord-010092-uftc8inx 10648 19 by by IN cord-010092-uftc8inx 10648 20 column column NN cord-010092-uftc8inx 10648 21 agglutination agglutination NN cord-010092-uftc8inx 10648 22 technology technology NN cord-010092-uftc8inx 10648 23 . . . cord-010092-uftc8inx 10649 1 Aims aim VBZ cord-010092-uftc8inx 10649 2 : : : cord-010092-uftc8inx 10649 3 We -PRON- PRP cord-010092-uftc8inx 10649 4 wanted want VBD cord-010092-uftc8inx 10649 5 to to TO cord-010092-uftc8inx 10649 6 assess assess VB cord-010092-uftc8inx 10649 7 the the DT cord-010092-uftc8inx 10649 8 performance performance NN cord-010092-uftc8inx 10649 9 of of IN cord-010092-uftc8inx 10649 10 titration titration NN cord-010092-uftc8inx 10649 11 and and CC cord-010092-uftc8inx 10649 12 scoring scoring NN cord-010092-uftc8inx 10649 13 by by IN cord-010092-uftc8inx 10649 14 the the DT cord-010092-uftc8inx 10649 15 ID ID NNP cord-010092-uftc8inx 10649 16 - - HYPH cord-010092-uftc8inx 10649 17 gel gel NN cord-010092-uftc8inx 10649 18 test test NN cord-010092-uftc8inx 10649 19 on on IN cord-010092-uftc8inx 10649 20 the the DT cord-010092-uftc8inx 10649 21 IH-500 IH-500 NNP cord-010092-uftc8inx 10649 22 system system NN cord-010092-uftc8inx 10649 23 ( ( -LRB- cord-010092-uftc8inx 10649 24 Bio Bio NNP cord-010092-uftc8inx 10649 25 - - HYPH cord-010092-uftc8inx 10649 26 Radâ Radâ NNP cord-010092-uftc8inx 10649 27 ) ) -RRB- cord-010092-uftc8inx 10649 28 and and CC cord-010092-uftc8inx 10649 29 to to TO cord-010092-uftc8inx 10649 30 compare compare VB cord-010092-uftc8inx 10649 31 it -PRON- PRP cord-010092-uftc8inx 10649 32 with with IN cord-010092-uftc8inx 10649 33 the the DT cord-010092-uftc8inx 10649 34 performance performance NN cord-010092-uftc8inx 10649 35 established establish VBN cord-010092-uftc8inx 10649 36 for for IN cord-010092-uftc8inx 10649 37 the the DT cord-010092-uftc8inx 10649 38 reference reference NN cord-010092-uftc8inx 10649 39 tube tube NN cord-010092-uftc8inx 10649 40 method method NN cord-010092-uftc8inx 10649 41 , , , cord-010092-uftc8inx 10649 42 used use VBN cord-010092-uftc8inx 10649 43 in in IN cord-010092-uftc8inx 10649 44 our -PRON- PRP$ cord-010092-uftc8inx 10649 45 lab lab NN cord-010092-uftc8inx 10649 46 since since IN cord-010092-uftc8inx 10649 47 decades decade NNS cord-010092-uftc8inx 10649 48 . . . cord-010092-uftc8inx 10650 1 Another another DT cord-010092-uftc8inx 10650 2 objective objective NN cord-010092-uftc8inx 10650 3 of of IN cord-010092-uftc8inx 10650 4 the the DT cord-010092-uftc8inx 10650 5 study study NN cord-010092-uftc8inx 10650 6 was be VBD cord-010092-uftc8inx 10650 7 to to TO cord-010092-uftc8inx 10650 8 determine determine VB cord-010092-uftc8inx 10650 9 titer titer NN cord-010092-uftc8inx 10650 10 thresholds threshold NNS cord-010092-uftc8inx 10650 11 for for IN cord-010092-uftc8inx 10650 12 the the DT cord-010092-uftc8inx 10650 13 gel gel NN cord-010092-uftc8inx 10650 14 method method NN cord-010092-uftc8inx 10650 15 , , , cord-010092-uftc8inx 10650 16 to to TO cord-010092-uftc8inx 10650 17 trigger trigger VB cord-010092-uftc8inx 10650 18 fetal fetal JJ cord-010092-uftc8inx 10650 19 monitoring monitoring NN cord-010092-uftc8inx 10650 20 by by IN cord-010092-uftc8inx 10650 21 ultrasounds ultrasound NNS cord-010092-uftc8inx 10650 22 and and CC cord-010092-uftc8inx 10650 23 measurements measurement NNS cord-010092-uftc8inx 10650 24 of of IN cord-010092-uftc8inx 10650 25 the the DT cord-010092-uftc8inx 10650 26 peak peak JJ cord-010092-uftc8inx 10650 27 systolic systolic JJ cord-010092-uftc8inx 10650 28 velocity velocity NN cord-010092-uftc8inx 10650 29 in in IN cord-010092-uftc8inx 10650 30 the the DT cord-010092-uftc8inx 10650 31 middle middle JJ cord-010092-uftc8inx 10650 32 cerebral cerebral JJ cord-010092-uftc8inx 10650 33 artery artery NN cord-010092-uftc8inx 10650 34 . . . cord-010092-uftc8inx 10651 1 Methods method NNS cord-010092-uftc8inx 10651 2 : : : cord-010092-uftc8inx 10652 1 An an DT cord-010092-uftc8inx 10652 2 home home NN cord-010092-uftc8inx 10652 3 - - HYPH cord-010092-uftc8inx 10652 4 made make VBN cord-010092-uftc8inx 10652 5 internal internal JJ cord-010092-uftc8inx 10652 6 quality quality NN cord-010092-uftc8inx 10652 7 control control NN cord-010092-uftc8inx 10652 8 ( ( -LRB- cord-010092-uftc8inx 10652 9 IQC IQC NNP cord-010092-uftc8inx 10652 10 ) ) -RRB- cord-010092-uftc8inx 10652 11 prepared prepare VBD cord-010092-uftc8inx 10652 12 and and CC cord-010092-uftc8inx 10652 13 calibrated calibrate VBN cord-010092-uftc8inx 10652 14 using use VBG cord-010092-uftc8inx 10652 15 the the DT cord-010092-uftc8inx 10652 16 international international JJ cord-010092-uftc8inx 10652 17 anti anti JJ cord-010092-uftc8inx 10652 18 - - JJ cord-010092-uftc8inx 10652 19 D d JJ cord-010092-uftc8inx 10652 20 Standard standard NN cord-010092-uftc8inx 10652 21 ( ( -LRB- cord-010092-uftc8inx 10652 22 01/572 01/572 CD cord-010092-uftc8inx 10652 23 ) ) -RRB- cord-010092-uftc8inx 10652 24 was be VBD cord-010092-uftc8inx 10652 25 used use VBN cord-010092-uftc8inx 10652 26 to to TO cord-010092-uftc8inx 10652 27 determine determine VB cord-010092-uftc8inx 10652 28 the the DT cord-010092-uftc8inx 10652 29 intraassay intraassay NNP cord-010092-uftc8inx 10652 30 and and CC cord-010092-uftc8inx 10652 31 interassay interassay NNP cord-010092-uftc8inx 10652 32 imprecisions imprecision NNS cord-010092-uftc8inx 10652 33 , , , cord-010092-uftc8inx 10652 34 regarding regard VBG cord-010092-uftc8inx 10652 35 the the DT cord-010092-uftc8inx 10652 36 score score NN cord-010092-uftc8inx 10652 37 and and CC cord-010092-uftc8inx 10652 38 the the DT cord-010092-uftc8inx 10652 39 titer titer NN cord-010092-uftc8inx 10652 40 results result NNS cord-010092-uftc8inx 10652 41 . . . cord-010092-uftc8inx 10653 1 Patients patient NNS cord-010092-uftc8inx 10653 2 samples sample NNS cord-010092-uftc8inx 10653 3 for for IN cord-010092-uftc8inx 10653 4 testing testing NN cord-010092-uftc8inx 10653 5 were be VBD cord-010092-uftc8inx 10653 6 chosen choose VBN cord-010092-uftc8inx 10653 7 during during IN cord-010092-uftc8inx 10653 8 the the DT cord-010092-uftc8inx 10653 9 2-months 2-months CD cord-010092-uftc8inx 10653 10 assay assay NN cord-010092-uftc8inx 10653 11 period period NN cord-010092-uftc8inx 10653 12 , , , cord-010092-uftc8inx 10653 13 regarding regard VBG cord-010092-uftc8inx 10653 14 the the DT cord-010092-uftc8inx 10653 15 specificity specificity NN cord-010092-uftc8inx 10653 16 of of IN cord-010092-uftc8inx 10653 17 the the DT cord-010092-uftc8inx 10653 18 antibodies antibody NNS cord-010092-uftc8inx 10653 19 and and CC cord-010092-uftc8inx 10653 20 the the DT cord-010092-uftc8inx 10653 21 tube tube NN cord-010092-uftc8inx 10653 22 titer titer NN cord-010092-uftc8inx 10653 23 in in IN cord-010092-uftc8inx 10653 24 order order NN cord-010092-uftc8inx 10653 25 to to TO cord-010092-uftc8inx 10653 26 cover cover VB cord-010092-uftc8inx 10653 27 a a DT cord-010092-uftc8inx 10653 28 wide wide JJ cord-010092-uftc8inx 10653 29 range range NN cord-010092-uftc8inx 10653 30 of of IN cord-010092-uftc8inx 10653 31 2 2 CD cord-010092-uftc8inx 10653 32 have have VBP cord-010092-uftc8inx 10653 33 lower low JJR cord-010092-uftc8inx 10653 34 values value NNS cord-010092-uftc8inx 10653 35 . . . cord-010092-uftc8inx 10654 1 The the DT cord-010092-uftc8inx 10654 2 highest high JJS cord-010092-uftc8inx 10654 3 differences difference NNS cord-010092-uftc8inx 10654 4 ( ( -LRB- cord-010092-uftc8inx 10654 5 more more JJR cord-010092-uftc8inx 10654 6 than than IN cord-010092-uftc8inx 10654 7 2 2 CD cord-010092-uftc8inx 10654 8 to to TO cord-010092-uftc8inx 10654 9 3 3 CD cord-010092-uftc8inx 10654 10 dilutions dilution NNS cord-010092-uftc8inx 10654 11 higher high JJR cord-010092-uftc8inx 10654 12 ) ) -RRB- cord-010092-uftc8inx 10654 13 were be VBD cord-010092-uftc8inx 10654 14 seen see VBN cord-010092-uftc8inx 10654 15 for for IN cord-010092-uftc8inx 10654 16 antibodies antibody NNS cord-010092-uftc8inx 10654 17 directed direct VBN cord-010092-uftc8inx 10654 18 against against IN cord-010092-uftc8inx 10654 19 RH RH NNP cord-010092-uftc8inx 10654 20 system system NN cord-010092-uftc8inx 10654 21 antigens antigen NNS cord-010092-uftc8inx 10654 22 . . . cord-010092-uftc8inx 10655 1 Among among IN cord-010092-uftc8inx 10655 2 the the DT cord-010092-uftc8inx 10655 3 other other JJ cord-010092-uftc8inx 10655 4 specificities specificity NNS cord-010092-uftc8inx 10655 5 , , , cord-010092-uftc8inx 10655 6 Anti Anti NNP cord-010092-uftc8inx 10655 7 - - NNP cord-010092-uftc8inx 10655 8 K K NNP cord-010092-uftc8inx 10655 9 ( ( -LRB- cord-010092-uftc8inx 10655 10 KEL1 KEL1 NNP cord-010092-uftc8inx 10655 11 ) ) -RRB- cord-010092-uftc8inx 10655 12 and and CC cord-010092-uftc8inx 10655 13 anti anti JJ cord-010092-uftc8inx 10655 14 - - JJ cord-010092-uftc8inx 10655 15 M m JJ cord-010092-uftc8inx 10655 16 ( ( -LRB- cord-010092-uftc8inx 10655 17 MNS1 MNS1 NNP cord-010092-uftc8inx 10655 18 ) ) -RRB- cord-010092-uftc8inx 10655 19 antibodies antibody NNS cord-010092-uftc8inx 10655 20 show show VBP cord-010092-uftc8inx 10655 21 the the DT cord-010092-uftc8inx 10655 22 most most JJS cord-010092-uftc8inx 10655 23 samples sample NNS cord-010092-uftc8inx 10655 24 with with IN cord-010092-uftc8inx 10655 25 equal equal JJ cord-010092-uftc8inx 10655 26 or or CC cord-010092-uftc8inx 10655 27 lower low JJR cord-010092-uftc8inx 10655 28 titers titer NNS cord-010092-uftc8inx 10655 29 compared compare VBN cord-010092-uftc8inx 10655 30 to to IN cord-010092-uftc8inx 10655 31 the the DT cord-010092-uftc8inx 10655 32 tube tube NN cord-010092-uftc8inx 10655 33 method method NN cord-010092-uftc8inx 10655 34 . . . cord-010092-uftc8inx 10656 1 Conclusions conclusion NNS cord-010092-uftc8inx 10656 2 : : : cord-010092-uftc8inx 10657 1 Automated automate VBN cord-010092-uftc8inx 10657 2 anti anti JJ cord-010092-uftc8inx 10657 3 - - JJ cord-010092-uftc8inx 10657 4 red red JJ cord-010092-uftc8inx 10657 5 blood blood NN cord-010092-uftc8inx 10657 6 cell cell NN cord-010092-uftc8inx 10657 7 antibodies antibody NNS cord-010092-uftc8inx 10657 8 titration titration NN cord-010092-uftc8inx 10657 9 by by IN cord-010092-uftc8inx 10657 10 column column NN cord-010092-uftc8inx 10657 11 agglutination agglutination NN cord-010092-uftc8inx 10657 12 technology technology NN cord-010092-uftc8inx 10657 13 on on IN cord-010092-uftc8inx 10657 14 IH-500 IH-500 NNP cord-010092-uftc8inx 10657 15 system system NN cord-010092-uftc8inx 10657 16 shows show VBZ cord-010092-uftc8inx 10657 17 better well JJR cord-010092-uftc8inx 10657 18 intra intra NNP cord-010092-uftc8inx 10657 19 and and CC cord-010092-uftc8inx 10657 20 interassay interassay JJ cord-010092-uftc8inx 10657 21 CVs CVs NNPS cord-010092-uftc8inx 10657 22 compared compare VBN cord-010092-uftc8inx 10657 23 to to IN cord-010092-uftc8inx 10657 24 the the DT cord-010092-uftc8inx 10657 25 tube tube NN cord-010092-uftc8inx 10657 26 method method NN cord-010092-uftc8inx 10657 27 . . . cord-010092-uftc8inx 10658 1 It -PRON- PRP cord-010092-uftc8inx 10658 2 is be VBZ cord-010092-uftc8inx 10658 3 explained explain VBN cord-010092-uftc8inx 10658 4 by by IN cord-010092-uftc8inx 10658 5 the the DT cord-010092-uftc8inx 10658 6 fully fully RB cord-010092-uftc8inx 10658 7 automated automate VBN cord-010092-uftc8inx 10658 8 process process NN cord-010092-uftc8inx 10658 9 that that WDT cord-010092-uftc8inx 10658 10 includes include VBZ cord-010092-uftc8inx 10658 11 the the DT cord-010092-uftc8inx 10658 12 reading reading NN cord-010092-uftc8inx 10658 13 step step NN cord-010092-uftc8inx 10658 14 . . . cord-010092-uftc8inx 10659 1 Titer titer NN cord-010092-uftc8inx 10659 2 results result NNS cord-010092-uftc8inx 10659 3 are be VBP cord-010092-uftc8inx 10659 4 almost almost RB cord-010092-uftc8inx 10659 5 always always RB cord-010092-uftc8inx 10659 6 higher high JJR cord-010092-uftc8inx 10659 7 with with IN cord-010092-uftc8inx 10659 8 the the DT cord-010092-uftc8inx 10659 9 gel gel NN cord-010092-uftc8inx 10659 10 technology technology NN cord-010092-uftc8inx 10659 11 . . . cord-010092-uftc8inx 10660 1 Thus thus RB cord-010092-uftc8inx 10660 2 , , , cord-010092-uftc8inx 10660 3 it -PRON- PRP cord-010092-uftc8inx 10660 4 seems seem VBZ cord-010092-uftc8inx 10660 5 possible possible JJ cord-010092-uftc8inx 10660 6 to to TO cord-010092-uftc8inx 10660 7 safely safely RB cord-010092-uftc8inx 10660 8 extrapolate extrapolate VB cord-010092-uftc8inx 10660 9 the the DT cord-010092-uftc8inx 10660 10 titer titer NN cord-010092-uftc8inx 10660 11 thresholds threshold NNS cord-010092-uftc8inx 10660 12 defined define VBN cord-010092-uftc8inx 10660 13 for for IN cord-010092-uftc8inx 10660 14 anti anti JJ cord-010092-uftc8inx 10660 15 - - JJ cord-010092-uftc8inx 10660 16 red red JJ cord-010092-uftc8inx 10660 17 blood blood NN cord-010092-uftc8inx 10660 18 cells cell NNS cord-010092-uftc8inx 10660 19 antibodies antibody NNS cord-010092-uftc8inx 10660 20 by by IN cord-010092-uftc8inx 10660 21 the the DT cord-010092-uftc8inx 10660 22 tube tube NN cord-010092-uftc8inx 10660 23 method method NN cord-010092-uftc8inx 10660 24 to to IN cord-010092-uftc8inx 10660 25 the the DT cord-010092-uftc8inx 10660 26 gel gel NN cord-010092-uftc8inx 10660 27 method method NN cord-010092-uftc8inx 10660 28 . . . cord-010092-uftc8inx 10661 1 However however RB cord-010092-uftc8inx 10661 2 , , , cord-010092-uftc8inx 10661 3 based base VBN cord-010092-uftc8inx 10661 4 on on IN cord-010092-uftc8inx 10661 5 future future JJ cord-010092-uftc8inx 10661 6 clinical clinical JJ cord-010092-uftc8inx 10661 7 studies study NNS cord-010092-uftc8inx 10661 8 and and CC cord-010092-uftc8inx 10661 9 fetal fetal JJ cord-010092-uftc8inx 10661 10 / / SYM cord-010092-uftc8inx 10661 11 neonatal neonatal JJ cord-010092-uftc8inx 10661 12 outcomes outcome NNS cord-010092-uftc8inx 10661 13 , , , cord-010092-uftc8inx 10661 14 it -PRON- PRP cord-010092-uftc8inx 10661 15 would would MD cord-010092-uftc8inx 10661 16 probably probably RB cord-010092-uftc8inx 10661 17 be be VB cord-010092-uftc8inx 10661 18 necessary necessary JJ cord-010092-uftc8inx 10661 19 to to TO cord-010092-uftc8inx 10661 20 increase increase VB cord-010092-uftc8inx 10661 21 these these DT cord-010092-uftc8inx 10661 22 thresholds threshold NNS cord-010092-uftc8inx 10661 23 , , , cord-010092-uftc8inx 10661 24 at at IN cord-010092-uftc8inx 10661 25 least least JJS cord-010092-uftc8inx 10661 26 for for IN cord-010092-uftc8inx 10661 27 anti anti JJ cord-010092-uftc8inx 10661 28 - - JJ cord-010092-uftc8inx 10661 29 RH rh JJ cord-010092-uftc8inx 10661 30 antibodies antibody NNS cord-010092-uftc8inx 10661 31 , , , cord-010092-uftc8inx 10661 32 in in IN cord-010092-uftc8inx 10661 33 order order NN cord-010092-uftc8inx 10661 34 to to TO cord-010092-uftc8inx 10661 35 avoid avoid VB cord-010092-uftc8inx 10661 36 heavy heavy JJ cord-010092-uftc8inx 10661 37 , , , cord-010092-uftc8inx 10661 38 expensive expensive JJ cord-010092-uftc8inx 10661 39 , , , cord-010092-uftc8inx 10661 40 stressful stressful JJ cord-010092-uftc8inx 10661 41 and and CC cord-010092-uftc8inx 10661 42 useless useless JJ cord-010092-uftc8inx 10661 43 monitoring monitoring NN cord-010092-uftc8inx 10661 44 of of IN cord-010092-uftc8inx 10661 45 some some DT cord-010092-uftc8inx 10661 46 pregnancies pregnancy NNS cord-010092-uftc8inx 10661 47 . . . cord-010092-uftc8inx 10662 1 Results result NNS cord-010092-uftc8inx 10662 2 : : : cord-010092-uftc8inx 10663 1 The the DT cord-010092-uftc8inx 10663 2 first first JJ cord-010092-uftc8inx 10663 3 case case NN cord-010092-uftc8inx 10663 4 was be VBD cord-010092-uftc8inx 10663 5 a a DT cord-010092-uftc8inx 10663 6 1-day 1-day JJ cord-010092-uftc8inx 10663 7 - - HYPH cord-010092-uftc8inx 10663 8 old old JJ cord-010092-uftc8inx 10663 9 female female JJ cord-010092-uftc8inx 10663 10 infant infant NN cord-010092-uftc8inx 10663 11 , , , cord-010092-uftc8inx 10663 12 yellowish yellowish JJ cord-010092-uftc8inx 10663 13 skin skin NN cord-010092-uftc8inx 10663 14 developed develop VBD cord-010092-uftc8inx 10663 15 the the DT cord-010092-uftc8inx 10663 16 next next JJ cord-010092-uftc8inx 10663 17 day day NN cord-010092-uftc8inx 10663 18 after after IN cord-010092-uftc8inx 10663 19 birth birth NN cord-010092-uftc8inx 10663 20 . . . cord-010092-uftc8inx 10664 1 Her -PRON- PRP$ cord-010092-uftc8inx 10664 2 capillary capillary JJ cord-010092-uftc8inx 10664 3 bilirubin bilirubin NN cord-010092-uftc8inx 10664 4 level level NN cord-010092-uftc8inx 10664 5 was be VBD cord-010092-uftc8inx 10664 6 13 13 CD cord-010092-uftc8inx 10664 7 mg mg NN cord-010092-uftc8inx 10664 8 / / SYM cord-010092-uftc8inx 10664 9 dL dl NN cord-010092-uftc8inx 10665 1 , , , cord-010092-uftc8inx 10665 2 the the DT cord-010092-uftc8inx 10665 3 evidence evidence NN cord-010092-uftc8inx 10665 4 favored favor VBD cord-010092-uftc8inx 10665 5 neonatal neonatal JJ cord-010092-uftc8inx 10665 6 hyperbilirubinemia hyperbilirubinemia NN cord-010092-uftc8inx 10665 7 and and CC cord-010092-uftc8inx 10665 8 the the DT cord-010092-uftc8inx 10665 9 clinical clinical JJ cord-010092-uftc8inx 10665 10 manifestation manifestation NN cord-010092-uftc8inx 10665 11 revealed reveal VBD cord-010092-uftc8inx 10665 12 hemolysis hemolysis NN cord-010092-uftc8inx 10665 13 symptoms symptom NNS cord-010092-uftc8inx 10665 14 . . . cord-010092-uftc8inx 10666 1 Her -PRON- PRP$ cord-010092-uftc8inx 10666 2 laboratory laboratory NN cord-010092-uftc8inx 10666 3 findings finding NNS cord-010092-uftc8inx 10666 4 showed show VBD cord-010092-uftc8inx 10666 5 elevated elevated JJ cord-010092-uftc8inx 10666 6 reticulocytes reticulocyte NNS cord-010092-uftc8inx 10666 7 ( ( -LRB- cord-010092-uftc8inx 10666 8 15.2 15.2 CD cord-010092-uftc8inx 10666 9 % % NN cord-010092-uftc8inx 10666 10 ) ) -RRB- cord-010092-uftc8inx 10666 11 , , , cord-010092-uftc8inx 10666 12 LDH LDH NNP cord-010092-uftc8inx 10666 13 ( ( -LRB- cord-010092-uftc8inx 10666 14 1162 1162 CD cord-010092-uftc8inx 10666 15 IU IU NNP cord-010092-uftc8inx 10666 16 / / SYM cord-010092-uftc8inx 10666 17 L L NNP cord-010092-uftc8inx 10666 18 ) ) -RRB- cord-010092-uftc8inx 10666 19 and and CC cord-010092-uftc8inx 10666 20 G6PD G6PD NNP cord-010092-uftc8inx 10666 21 ( ( -LRB- cord-010092-uftc8inx 10666 22 25.3 25.3 CD cord-010092-uftc8inx 10666 23 U U NNP cord-010092-uftc8inx 10666 24 / / SYM cord-010092-uftc8inx 10666 25 gHb gHb NNP cord-010092-uftc8inx 10666 26 ) ) -RRB- cord-010092-uftc8inx 10666 27 ; ; : cord-010092-uftc8inx 10666 28 DAT DAT NNP cord-010092-uftc8inx 10666 29 ( ( -LRB- cord-010092-uftc8inx 10666 30 + + CC cord-010092-uftc8inx 10666 31 /- /- . cord-010092-uftc8inx 10666 32 ) ) -RRB- cord-010092-uftc8inx 10666 33 , , , cord-010092-uftc8inx 10666 34 IAT IAT NNP cord-010092-uftc8inx 10666 35 ( ( -LRB- cord-010092-uftc8inx 10666 36 - - : cord-010092-uftc8inx 10666 37 ) ) -RRB- cord-010092-uftc8inx 10666 38 , , , cord-010092-uftc8inx 10666 39 anemia anemia NN cord-010092-uftc8inx 10666 40 ( ( -LRB- cord-010092-uftc8inx 10667 1 Hb Hb NNP cord-010092-uftc8inx 10667 2 8.7 8.7 CD cord-010092-uftc8inx 10667 3 g g NN cord-010092-uftc8inx 10667 4 / / SYM cord-010092-uftc8inx 10667 5 dl dl NN cord-010092-uftc8inx 10667 6 , , , cord-010092-uftc8inx 10667 7 Hct Hct NNP cord-010092-uftc8inx 10667 8 28 28 CD cord-010092-uftc8inx 10667 9 % % NN cord-010092-uftc8inx 10667 10 ) ) -RRB- cord-010092-uftc8inx 10667 11 , , , cord-010092-uftc8inx 10667 12 and and CC cord-010092-uftc8inx 10667 13 blood blood NN cord-010092-uftc8inx 10667 14 smear smear NN cord-010092-uftc8inx 10667 15 showed show VBD cord-010092-uftc8inx 10667 16 anisocytosis anisocytosis NN cord-010092-uftc8inx 10667 17 , , , cord-010092-uftc8inx 10667 18 spherocytes spherocyte NNS cord-010092-uftc8inx 10667 19 , , , cord-010092-uftc8inx 10667 20 and and CC cord-010092-uftc8inx 10667 21 polychromatic polychromatic JJ cord-010092-uftc8inx 10667 22 RBC RBC NNP cord-010092-uftc8inx 10667 23 . . . cord-010092-uftc8inx 10668 1 Her -PRON- PRP$ cord-010092-uftc8inx 10668 2 mother mother NN cord-010092-uftc8inx 10668 3 blood blood NN cord-010092-uftc8inx 10668 4 typed type VBD cord-010092-uftc8inx 10668 5 O o UH cord-010092-uftc8inx 10668 6 , , , cord-010092-uftc8inx 10668 7 D D NNP cord-010092-uftc8inx 10668 8 positive positive JJ cord-010092-uftc8inx 10668 9 , , , cord-010092-uftc8inx 10668 10 while while IN cord-010092-uftc8inx 10668 11 her -PRON- PRP$ cord-010092-uftc8inx 10668 12 blood blood NN cord-010092-uftc8inx 10668 13 type type NN cord-010092-uftc8inx 10668 14 was be VBD cord-010092-uftc8inx 10668 15 B b NN cord-010092-uftc8inx 10668 16 , , , cord-010092-uftc8inx 10668 17 D D NNP cord-010092-uftc8inx 10668 18 positive positive JJ cord-010092-uftc8inx 10668 19 and and CC cord-010092-uftc8inx 10668 20 Anti Anti NNP cord-010092-uftc8inx 10668 21 - - NNP cord-010092-uftc8inx 10668 22 B B NNP cord-010092-uftc8inx 10668 23 was be VBD cord-010092-uftc8inx 10668 24 found find VBN cord-010092-uftc8inx 10668 25 from from IN cord-010092-uftc8inx 10668 26 her -PRON- PRP$ cord-010092-uftc8inx 10668 27 elution elution NN cord-010092-uftc8inx 10668 28 RBCs rbc NNS cord-010092-uftc8inx 10668 29 ( ( -LRB- cord-010092-uftc8inx 10668 30 3 3 CD cord-010092-uftc8inx 10668 31 + + SYM cord-010092-uftc8inx 10668 32 ) ) -RRB- cord-010092-uftc8inx 10668 33 . . . cord-010092-uftc8inx 10669 1 Due due IN cord-010092-uftc8inx 10669 2 to to IN cord-010092-uftc8inx 10669 3 rarely rarely RB cord-010092-uftc8inx 10669 4 severe severe JJ cord-010092-uftc8inx 10669 5 anemia anemia NN cord-010092-uftc8inx 10669 6 with with IN cord-010092-uftc8inx 10669 7 ABO ABO NNP cord-010092-uftc8inx 10669 8 incompatibility incompatibility NN cord-010092-uftc8inx 10669 9 , , , cord-010092-uftc8inx 10669 10 maternal maternal JJ cord-010092-uftc8inx 10669 11 plasma plasma NN cord-010092-uftc8inx 10669 12 was be VBD cord-010092-uftc8inx 10669 13 analysed analyse VBN cord-010092-uftc8inx 10669 14 for for IN cord-010092-uftc8inx 10669 15 ABO ABO NNP cord-010092-uftc8inx 10669 16 IgG igg NN cord-010092-uftc8inx 10669 17 Antibodies Antibodies NNPS cord-010092-uftc8inx 10669 18 and and CC cord-010092-uftc8inx 10669 19 showed show VBD cord-010092-uftc8inx 10669 20 high high JJ cord-010092-uftc8inx 10669 21 antibody antibody NN cord-010092-uftc8inx 10669 22 A a NN cord-010092-uftc8inx 10669 23 and and CC cord-010092-uftc8inx 10669 24 B B NNP cord-010092-uftc8inx 10669 25 titre titre NN cord-010092-uftc8inx 10669 26 with with IN cord-010092-uftc8inx 10669 27 1:1024 1:1024 CD cord-010092-uftc8inx 10669 28 and and CC cord-010092-uftc8inx 10669 29 1:2048 1:2048 NNS cord-010092-uftc8inx 10669 30 . . . cord-010092-uftc8inx 10670 1 The the DT cord-010092-uftc8inx 10670 2 female female JJ cord-010092-uftc8inx 10670 3 infant infant NN cord-010092-uftc8inx 10670 4 received receive VBD cord-010092-uftc8inx 10670 5 one one CD cord-010092-uftc8inx 10670 6 unit unit NN cord-010092-uftc8inx 10670 7 washed wash VBN cord-010092-uftc8inx 10670 8 - - HYPH cord-010092-uftc8inx 10670 9 PRBCs prbc NNS cord-010092-uftc8inx 10670 10 for for IN cord-010092-uftc8inx 10670 11 anemia anemia NN cord-010092-uftc8inx 10670 12 and and CC cord-010092-uftc8inx 10670 13 intensive intensive JJ cord-010092-uftc8inx 10670 14 phototherapy phototherapy NN cord-010092-uftc8inx 10670 15 for for IN cord-010092-uftc8inx 10670 16 hyperbilirubinemia hyperbilirubinemia NN cord-010092-uftc8inx 10670 17 . . . cord-010092-uftc8inx 10671 1 Her -PRON- PRP$ cord-010092-uftc8inx 10671 2 clinical clinical JJ cord-010092-uftc8inx 10671 3 condition condition NN cord-010092-uftc8inx 10671 4 improved improve VBD cord-010092-uftc8inx 10671 5 significantly significantly RB cord-010092-uftc8inx 10671 6 , , , cord-010092-uftc8inx 10671 7 Hb Hb NNP cord-010092-uftc8inx 10671 8 rose rise VBD cord-010092-uftc8inx 10671 9 to to IN cord-010092-uftc8inx 10671 10 14.6 14.6 CD cord-010092-uftc8inx 10671 11 , , , cord-010092-uftc8inx 10671 12 bilirubin bilirubin JJ cord-010092-uftc8inx 10671 13 level level NN cord-010092-uftc8inx 10671 14 was be VBD cord-010092-uftc8inx 10671 15 within within IN cord-010092-uftc8inx 10671 16 normal normal JJ cord-010092-uftc8inx 10671 17 range range NN cord-010092-uftc8inx 10671 18 , , , cord-010092-uftc8inx 10671 19 she -PRON- PRP cord-010092-uftc8inx 10671 20 was be VBD cord-010092-uftc8inx 10671 21 discharged discharge VBN cord-010092-uftc8inx 10671 22 . . . cord-010092-uftc8inx 10672 1 Another another DT cord-010092-uftc8inx 10672 2 5-days 5-days CD cord-010092-uftc8inx 10672 3 - - HYPH cord-010092-uftc8inx 10672 4 old old JJ cord-010092-uftc8inx 10672 5 male male JJ cord-010092-uftc8inx 10672 6 infant infant NN cord-010092-uftc8inx 10672 7 was be VBD cord-010092-uftc8inx 10672 8 our -PRON- PRP$ cord-010092-uftc8inx 10672 9 second second JJ cord-010092-uftc8inx 10672 10 case case NN cord-010092-uftc8inx 10672 11 . . . cord-010092-uftc8inx 10673 1 On on IN cord-010092-uftc8inx 10673 2 the the DT cord-010092-uftc8inx 10673 3 third third JJ cord-010092-uftc8inx 10673 4 day day NN cord-010092-uftc8inx 10673 5 after after IN cord-010092-uftc8inx 10673 6 birth birth NN cord-010092-uftc8inx 10673 7 , , , cord-010092-uftc8inx 10673 8 yellowish yellowish JJ cord-010092-uftc8inx 10673 9 skin skin NN cord-010092-uftc8inx 10673 10 discoloration discoloration NN cord-010092-uftc8inx 10673 11 developed develop VBN cord-010092-uftc8inx 10673 12 and and CC cord-010092-uftc8inx 10673 13 bilirubin bilirubin JJ cord-010092-uftc8inx 10673 14 level level NN cord-010092-uftc8inx 10673 15 was be VBD cord-010092-uftc8inx 10673 16 15 15 CD cord-010092-uftc8inx 10673 17 mg/ mg/ NN cord-010092-uftc8inx 10674 1 dL. dL. NNP cord-010092-uftc8inx 10675 1 Two two CD cord-010092-uftc8inx 10675 2 days day NNS cord-010092-uftc8inx 10675 3 later later RB cord-010092-uftc8inx 10675 4 , , , cord-010092-uftc8inx 10675 5 his -PRON- PRP$ cord-010092-uftc8inx 10675 6 Transcutaneous transcutaneous JJ cord-010092-uftc8inx 10675 7 bilirubin bilirubin NN cord-010092-uftc8inx 10675 8 ( ( -LRB- cord-010092-uftc8inx 10675 9 TcB TcB NNP cord-010092-uftc8inx 10675 10 ) ) -RRB- cord-010092-uftc8inx 10675 11 measurement measurement NN cord-010092-uftc8inx 10675 12 data data NN cord-010092-uftc8inx 10675 13 was be VBD cord-010092-uftc8inx 10676 1 high high JJ cord-010092-uftc8inx 10676 2 and and CC cord-010092-uftc8inx 10676 3 laboratory laboratory NN cord-010092-uftc8inx 10676 4 findings finding NNS cord-010092-uftc8inx 10676 5 also also RB cord-010092-uftc8inx 10676 6 showed show VBD cord-010092-uftc8inx 10676 7 raised raise VBN cord-010092-uftc8inx 10676 8 reticulocytes reticulocyte NNS cord-010092-uftc8inx 10676 9 ( ( -LRB- cord-010092-uftc8inx 10676 10 5.2 5.2 CD cord-010092-uftc8inx 10676 11 % % NN cord-010092-uftc8inx 10676 12 ) ) -RRB- cord-010092-uftc8inx 10676 13 , , , cord-010092-uftc8inx 10676 14 DAT DAT NNP cord-010092-uftc8inx 10676 15 ( ( -LRB- cord-010092-uftc8inx 10676 16 + + CC cord-010092-uftc8inx 10676 17 /À /à JJ cord-010092-uftc8inx 10676 18 ) ) -RRB- cord-010092-uftc8inx 10676 19 , , , cord-010092-uftc8inx 10676 20 IAT IAT NNP cord-010092-uftc8inx 10676 21 ( ( -LRB- cord-010092-uftc8inx 10676 22 À à NN cord-010092-uftc8inx 10676 23 ) ) -RRB- cord-010092-uftc8inx 10676 24 , , , cord-010092-uftc8inx 10676 25 Hb Hb NNP cord-010092-uftc8inx 10676 26 12 12 CD cord-010092-uftc8inx 10676 27 . . . cord-010092-uftc8inx 10677 1 Background background NN cord-010092-uftc8inx 10677 2 : : : cord-010092-uftc8inx 10678 1 Anti anti JJ cord-010092-uftc8inx 10678 2 - - JJ cord-010092-uftc8inx 10678 3 Indian indian JJ cord-010092-uftc8inx 10678 4 b b NNP cord-010092-uftc8inx 10678 5 is be VBZ cord-010092-uftc8inx 10678 6 a a DT cord-010092-uftc8inx 10678 7 rare rare JJ cord-010092-uftc8inx 10678 8 alloantibody alloantibody NN cord-010092-uftc8inx 10678 9 against against IN cord-010092-uftc8inx 10678 10 the the DT cord-010092-uftc8inx 10678 11 high high JJ cord-010092-uftc8inx 10678 12 frequency frequency NN cord-010092-uftc8inx 10678 13 antigen antigen NN cord-010092-uftc8inx 10678 14 In in IN cord-010092-uftc8inx 10678 15 b b NN cord-010092-uftc8inx 10678 16 . . . cord-010092-uftc8inx 10679 1 Individuals individual NNS cord-010092-uftc8inx 10679 2 with with IN cord-010092-uftc8inx 10679 3 the the DT cord-010092-uftc8inx 10679 4 IN:1,-2 IN:1,-2 NNP cord-010092-uftc8inx 10679 5 phenotype phenotype NN cord-010092-uftc8inx 10679 6 ( ( -LRB- cord-010092-uftc8inx 10679 7 In(a+b- in(a+b- NN cord-010092-uftc8inx 10679 8 ) ) -RRB- cord-010092-uftc8inx 10679 9 ) ) -RRB- cord-010092-uftc8inx 10679 10 are be VBP cord-010092-uftc8inx 10679 11 observed observe VBN cord-010092-uftc8inx 10679 12 with with IN cord-010092-uftc8inx 10679 13 a a DT cord-010092-uftc8inx 10679 14 frequency frequency NN cord-010092-uftc8inx 10679 15 of of IN cord-010092-uftc8inx 10679 16 < < $ cord-010092-uftc8inx 10679 17 0.1 0.1 CD cord-010092-uftc8inx 10679 18 % % NN cord-010092-uftc8inx 10679 19 in in IN cord-010092-uftc8inx 10679 20 the the DT cord-010092-uftc8inx 10679 21 Indian indian JJ cord-010092-uftc8inx 10679 22 population population NN cord-010092-uftc8inx 10679 23 and and CC cord-010092-uftc8inx 10679 24 have have VBP cord-010092-uftc8inx 10679 25 not not RB cord-010092-uftc8inx 10679 26 been be VBN cord-010092-uftc8inx 10679 27 described describe VBN cord-010092-uftc8inx 10679 28 in in IN cord-010092-uftc8inx 10679 29 Caucasians Caucasians NNPS cord-010092-uftc8inx 10679 30 . . . cord-010092-uftc8inx 10680 1 The the DT cord-010092-uftc8inx 10680 2 majority majority NN cord-010092-uftc8inx 10680 3 of of IN cord-010092-uftc8inx 10680 4 anti anti JJ cord-010092-uftc8inx 10680 5 - - JJ cord-010092-uftc8inx 10680 6 In in NN cord-010092-uftc8inx 10680 7 b b NN cord-010092-uftc8inx 10680 8 antibodies antibody NNS cord-010092-uftc8inx 10680 9 have have VBP cord-010092-uftc8inx 10680 10 been be VBN cord-010092-uftc8inx 10680 11 reported report VBN cord-010092-uftc8inx 10680 12 in in IN cord-010092-uftc8inx 10680 13 individuals individual NNS cord-010092-uftc8inx 10680 14 without without IN cord-010092-uftc8inx 10680 15 previous previous JJ cord-010092-uftc8inx 10680 16 transfusions transfusion NNS cord-010092-uftc8inx 10680 17 , , , cord-010092-uftc8inx 10680 18 indicating indicate VBG cord-010092-uftc8inx 10680 19 the the DT cord-010092-uftc8inx 10680 20 possibility possibility NN cord-010092-uftc8inx 10680 21 of of IN cord-010092-uftc8inx 10680 22 a a DT cord-010092-uftc8inx 10680 23 naturally naturally RB cord-010092-uftc8inx 10680 24 occurring occur VBG cord-010092-uftc8inx 10680 25 antibody antibody NN cord-010092-uftc8inx 10680 26 . . . cord-010092-uftc8inx 10681 1 Anti Anti NNP cord-010092-uftc8inx 10681 2 - - HYPH cord-010092-uftc8inx 10681 3 In in NN cord-010092-uftc8inx 10681 4 b b NN cord-010092-uftc8inx 10681 5 is be VBZ cord-010092-uftc8inx 10681 6 considered consider VBN cord-010092-uftc8inx 10681 7 clinically clinically RB cord-010092-uftc8inx 10681 8 significant significant JJ cord-010092-uftc8inx 10681 9 and and CC cord-010092-uftc8inx 10681 10 haemolytic haemolytic JJ cord-010092-uftc8inx 10681 11 reactions reaction NNS cord-010092-uftc8inx 10681 12 after after IN cord-010092-uftc8inx 10681 13 In in IN cord-010092-uftc8inx 10681 14 b b NN cord-010092-uftc8inx 10681 15 -incompatible -incompatible JJ cord-010092-uftc8inx 10681 16 transfusions transfusion NNS cord-010092-uftc8inx 10681 17 have have VBP cord-010092-uftc8inx 10681 18 been be VBN cord-010092-uftc8inx 10681 19 reported report VBN cord-010092-uftc8inx 10681 20 . . . cord-010092-uftc8inx 10682 1 Haemolytic haemolytic JJ cord-010092-uftc8inx 10682 2 disease disease NN cord-010092-uftc8inx 10682 3 of of IN cord-010092-uftc8inx 10682 4 the the DT cord-010092-uftc8inx 10682 5 foetus foetus NN cord-010092-uftc8inx 10682 6 and and CC cord-010092-uftc8inx 10682 7 newborn newborn JJ cord-010092-uftc8inx 10682 8 ( ( -LRB- cord-010092-uftc8inx 10682 9 HDFN HDFN NNP cord-010092-uftc8inx 10682 10 ) ) -RRB- cord-010092-uftc8inx 10682 11 due due JJ cord-010092-uftc8inx 10682 12 to to IN cord-010092-uftc8inx 10682 13 anti anti JJ cord-010092-uftc8inx 10682 14 - - JJ cord-010092-uftc8inx 10682 15 In in NN cord-010092-uftc8inx 10682 16 b b NN cord-010092-uftc8inx 10682 17 has have VBZ cord-010092-uftc8inx 10682 18 not not RB cord-010092-uftc8inx 10682 19 been be VBN cord-010092-uftc8inx 10682 20 described describe VBN cord-010092-uftc8inx 10682 21 . . . cord-010092-uftc8inx 10683 1 However however RB cord-010092-uftc8inx 10683 2 , , , cord-010092-uftc8inx 10683 3 a a DT cord-010092-uftc8inx 10683 4 positive positive JJ cord-010092-uftc8inx 10683 5 direct direct JJ cord-010092-uftc8inx 10683 6 antihuman antihuman JJ cord-010092-uftc8inx 10683 7 globulin globulin NN cord-010092-uftc8inx 10683 8 test test NN cord-010092-uftc8inx 10683 9 ( ( -LRB- cord-010092-uftc8inx 10683 10 DAT DAT NNP cord-010092-uftc8inx 10683 11 ) ) -RRB- cord-010092-uftc8inx 10683 12 may may MD cord-010092-uftc8inx 10683 13 be be VB cord-010092-uftc8inx 10683 14 observed observe VBN cord-010092-uftc8inx 10683 15 . . . cord-010092-uftc8inx 10684 1 Aims aim VBZ cord-010092-uftc8inx 10684 2 : : : cord-010092-uftc8inx 10684 3 To to TO cord-010092-uftc8inx 10684 4 describe describe VB cord-010092-uftc8inx 10684 5 the the DT cord-010092-uftc8inx 10684 6 challenges challenge NNS cord-010092-uftc8inx 10684 7 of of IN cord-010092-uftc8inx 10684 8 managing manage VBG cord-010092-uftc8inx 10684 9 a a DT cord-010092-uftc8inx 10684 10 pregnancy pregnancy NN cord-010092-uftc8inx 10684 11 and and CC cord-010092-uftc8inx 10684 12 childbirth childbirth NN cord-010092-uftc8inx 10684 13 of of IN cord-010092-uftc8inx 10684 14 a a DT cord-010092-uftc8inx 10684 15 woman woman NN cord-010092-uftc8inx 10684 16 with with IN cord-010092-uftc8inx 10684 17 an an DT cord-010092-uftc8inx 10684 18 anti anti NN cord-010092-uftc8inx 10684 19 - - NN cord-010092-uftc8inx 10684 20 In in NN cord-010092-uftc8inx 10684 21 b b NN cord-010092-uftc8inx 10684 22 . . . cord-010092-uftc8inx 10685 1 Methods method NNS cord-010092-uftc8inx 10685 2 : : : cord-010092-uftc8inx 10685 3 Serological serological JJ cord-010092-uftc8inx 10685 4 investigations investigation NNS cord-010092-uftc8inx 10685 5 were be VBD cord-010092-uftc8inx 10685 6 performed perform VBN cord-010092-uftc8inx 10685 7 by by IN cord-010092-uftc8inx 10685 8 IAT IAT NNP cord-010092-uftc8inx 10685 9 ( ( -LRB- cord-010092-uftc8inx 10685 10 tube tube NN cord-010092-uftc8inx 10685 11 and and CC cord-010092-uftc8inx 10685 12 column column NN cord-010092-uftc8inx 10685 13 agglutination agglutination NN cord-010092-uftc8inx 10685 14 ) ) -RRB- cord-010092-uftc8inx 10685 15 . . . cord-010092-uftc8inx 10686 1 Papain papain JJ cord-010092-uftc8inx 10686 2 and and CC cord-010092-uftc8inx 10686 3 trypsin trypsin NN cord-010092-uftc8inx 10686 4 treated treat VBN cord-010092-uftc8inx 10686 5 cells cell NNS cord-010092-uftc8inx 10686 6 were be VBD cord-010092-uftc8inx 10686 7 also also RB cord-010092-uftc8inx 10686 8 utilised utilise VBN cord-010092-uftc8inx 10686 9 . . . cord-010092-uftc8inx 10687 1 Soluble soluble JJ cord-010092-uftc8inx 10687 2 recombinant recombinant JJ cord-010092-uftc8inx 10688 1 In in IN cord-010092-uftc8inx 10688 2 blood blood NN cord-010092-uftc8inx 10688 3 group group NN cord-010092-uftc8inx 10688 4 proteins protein NNS cord-010092-uftc8inx 10689 1 ( ( -LRB- cord-010092-uftc8inx 10689 2 In in IN cord-010092-uftc8inx 10689 3 - - HYPH cord-010092-uftc8inx 10689 4 rBGP rbgp NN cord-010092-uftc8inx 10689 5 ) ) -RRB- cord-010092-uftc8inx 10689 6 ( ( -LRB- cord-010092-uftc8inx 10689 7 Inno Inno NNP cord-010092-uftc8inx 10689 8 - - HYPH cord-010092-uftc8inx 10689 9 Train Train NNP cord-010092-uftc8inx 10689 10 , , , cord-010092-uftc8inx 10689 11 Germany Germany NNP cord-010092-uftc8inx 10689 12 ) ) -RRB- cord-010092-uftc8inx 10689 13 were be VBD cord-010092-uftc8inx 10689 14 used use VBN cord-010092-uftc8inx 10689 15 in in IN cord-010092-uftc8inx 10689 16 neutralization neutralization NN cord-010092-uftc8inx 10689 17 tests test NNS cord-010092-uftc8inx 10689 18 . . . cord-010092-uftc8inx 10690 1 The the DT cord-010092-uftc8inx 10690 2 clinical clinical JJ cord-010092-uftc8inx 10690 3 significance significance NN cord-010092-uftc8inx 10690 4 of of IN cord-010092-uftc8inx 10690 5 the the DT cord-010092-uftc8inx 10690 6 anti anti NN cord-010092-uftc8inx 10690 7 - - NN cord-010092-uftc8inx 10690 8 In in NN cord-010092-uftc8inx 10690 9 b b NN cord-010092-uftc8inx 10690 10 antibody antibody NN cord-010092-uftc8inx 10690 11 was be VBD cord-010092-uftc8inx 10690 12 determined determine VBN cord-010092-uftc8inx 10690 13 by by IN cord-010092-uftc8inx 10690 14 monocyte monocyte NNP cord-010092-uftc8inx 10690 15 monolayer monolayer NN cord-010092-uftc8inx 10690 16 assay assay NN cord-010092-uftc8inx 10690 17 ( ( -LRB- cord-010092-uftc8inx 10690 18 MMA MMA NNP cord-010092-uftc8inx 10690 19 ) ) -RRB- cord-010092-uftc8inx 10690 20 . . . cord-010092-uftc8inx 10691 1 Genomic genomic JJ cord-010092-uftc8inx 10691 2 DNA dna NN cord-010092-uftc8inx 10691 3 was be VBD cord-010092-uftc8inx 10691 4 isolated isolate VBN cord-010092-uftc8inx 10691 5 from from IN cord-010092-uftc8inx 10691 6 whole whole JJ cord-010092-uftc8inx 10691 7 blood blood NN cord-010092-uftc8inx 10691 8 and and CC cord-010092-uftc8inx 10691 9 the the DT cord-010092-uftc8inx 10691 10 samples sample NNS cord-010092-uftc8inx 10691 11 were be VBD cord-010092-uftc8inx 10691 12 further further RB cord-010092-uftc8inx 10691 13 characterized characterize VBN cord-010092-uftc8inx 10691 14 by by IN cord-010092-uftc8inx 10691 15 PCR PCR NNP cord-010092-uftc8inx 10691 16 amplification amplification NN cord-010092-uftc8inx 10691 17 and and CC cord-010092-uftc8inx 10691 18 Sanger Sanger NNP cord-010092-uftc8inx 10691 19 sequencing sequencing NN cord-010092-uftc8inx 10691 20 of of IN cord-010092-uftc8inx 10691 21 exon exon NN cord-010092-uftc8inx 10691 22 2 2 CD cord-010092-uftc8inx 10691 23 of of IN cord-010092-uftc8inx 10691 24 CD44 CD44 NNP cord-010092-uftc8inx 10691 25 . . . cord-010092-uftc8inx 10692 1 Results result NNS cord-010092-uftc8inx 10692 2 : : : cord-010092-uftc8inx 10693 1 In in IN cord-010092-uftc8inx 10693 2 a a DT cord-010092-uftc8inx 10693 3 27-year 27-year JJ cord-010092-uftc8inx 10693 4 - - HYPH cord-010092-uftc8inx 10693 5 old old JJ cord-010092-uftc8inx 10693 6 pregnant pregnant JJ cord-010092-uftc8inx 10693 7 ( ( -LRB- cord-010092-uftc8inx 10693 8 para para NNP cord-010092-uftc8inx 10693 9 1 1 CD cord-010092-uftc8inx 10693 10 ) ) -RRB- cord-010092-uftc8inx 10693 11 woman woman NN cord-010092-uftc8inx 10693 12 of of IN cord-010092-uftc8inx 10693 13 Indian indian JJ cord-010092-uftc8inx 10693 14 origin origin NN cord-010092-uftc8inx 10693 15 without without IN cord-010092-uftc8inx 10693 16 previous previous JJ cord-010092-uftc8inx 10693 17 transfusions transfusion NNS cord-010092-uftc8inx 10693 18 , , , cord-010092-uftc8inx 10693 19 an an DT cord-010092-uftc8inx 10693 20 alloantibody alloantibody NN cord-010092-uftc8inx 10693 21 of of IN cord-010092-uftc8inx 10693 22 the the DT cord-010092-uftc8inx 10693 23 specificity specificity NN cord-010092-uftc8inx 10693 24 anti anti JJ cord-010092-uftc8inx 10693 25 - - JJ cord-010092-uftc8inx 10693 26 In in JJ cord-010092-uftc8inx 10693 27 b b NN cord-010092-uftc8inx 10693 28 with with IN cord-010092-uftc8inx 10693 29 a a DT cord-010092-uftc8inx 10693 30 titer titer NN cord-010092-uftc8inx 10693 31 of of IN cord-010092-uftc8inx 10693 32 1:2 1:2 CD cord-010092-uftc8inx 10693 33 was be VBD cord-010092-uftc8inx 10693 34 detected detect VBN cord-010092-uftc8inx 10693 35 by by IN cord-010092-uftc8inx 10693 36 IAT IAT NNP cord-010092-uftc8inx 10693 37 ( ( -LRB- cord-010092-uftc8inx 10693 38 negative negative JJ cord-010092-uftc8inx 10693 39 with with IN cord-010092-uftc8inx 10693 40 papain papain NN cord-010092-uftc8inx 10693 41 - - HYPH cord-010092-uftc8inx 10693 42 treated treat VBN cord-010092-uftc8inx 10693 43 cells cell NNS cord-010092-uftc8inx 10693 44 ) ) -RRB- cord-010092-uftc8inx 10693 45 at at IN cord-010092-uftc8inx 10693 46 gestational gestational JJ cord-010092-uftc8inx 10693 47 week week NN cord-010092-uftc8inx 10693 48 ( ( -LRB- cord-010092-uftc8inx 10693 49 GW GW NNP cord-010092-uftc8inx 10693 50 ) ) -RRB- cord-010092-uftc8inx 10693 51 32 32 CD cord-010092-uftc8inx 10693 52 and and CC cord-010092-uftc8inx 10693 53 36 36 CD cord-010092-uftc8inx 10693 54 . . . cord-010092-uftc8inx 10694 1 The the DT cord-010092-uftc8inx 10694 2 MMA MMA NNP cord-010092-uftc8inx 10694 3 , , , cord-010092-uftc8inx 10694 4 performed perform VBN cord-010092-uftc8inx 10694 5 in in IN cord-010092-uftc8inx 10694 6 duplicate duplicate NN cord-010092-uftc8inx 10694 7 on on IN cord-010092-uftc8inx 10694 8 samples sample NNS cord-010092-uftc8inx 10694 9 taken take VBN cord-010092-uftc8inx 10694 10 at at IN cord-010092-uftc8inx 10694 11 these these DT cord-010092-uftc8inx 10694 12 dates date NNS cord-010092-uftc8inx 10694 13 , , , cord-010092-uftc8inx 10694 14 showed show VBD cord-010092-uftc8inx 10694 15 a a DT cord-010092-uftc8inx 10694 16 MI MI NNP cord-010092-uftc8inx 10694 17 of of IN cord-010092-uftc8inx 10694 18 0.5%/4.8 0.5%/4.8 CD cord-010092-uftc8inx 10694 19 % % NN cord-010092-uftc8inx 10694 20 and and CC cord-010092-uftc8inx 10694 21 7.7%/6.3 7.7%/6.3 CD cord-010092-uftc8inx 10694 22 % % NN cord-010092-uftc8inx 10694 23 respectively respectively RB cord-010092-uftc8inx 10694 24 . . . cord-010092-uftc8inx 10695 1 The the DT cord-010092-uftc8inx 10695 2 MI MI NNP cord-010092-uftc8inx 10695 3 was be VBD cord-010092-uftc8inx 10695 4 interpreted interpret VBN cord-010092-uftc8inx 10695 5 as as IN cord-010092-uftc8inx 10695 6 follows follow VBZ cord-010092-uftc8inx 10695 7 : : : cord-010092-uftc8inx 10695 8 0 0 CD cord-010092-uftc8inx 10695 9 - - SYM cord-010092-uftc8inx 10695 10 3 3 CD cord-010092-uftc8inx 10695 11 % % NN cord-010092-uftc8inx 10695 12 not not RB cord-010092-uftc8inx 10695 13 relevant relevant JJ cord-010092-uftc8inx 10695 14 ; ; : cord-010092-uftc8inx 10695 15 3 3 CD cord-010092-uftc8inx 10695 16 - - SYM cord-010092-uftc8inx 10695 17 5 5 CD cord-010092-uftc8inx 10695 18 % % NN cord-010092-uftc8inx 10695 19 inconclusive inconclusive JJ cord-010092-uftc8inx 10695 20 ; ; : cord-010092-uftc8inx 10695 21 > > SYM cord-010092-uftc8inx 10695 22 5 5 CD cord-010092-uftc8inx 10695 23 % % NN cord-010092-uftc8inx 10695 24 clinical clinical JJ cord-010092-uftc8inx 10695 25 significant significant JJ cord-010092-uftc8inx 10695 26 . . . cord-010092-uftc8inx 10696 1 The the DT cord-010092-uftc8inx 10696 2 patient patient NN cord-010092-uftc8inx 10696 3 's 's POS cord-010092-uftc8inx 10696 4 parents parent NNS cord-010092-uftc8inx 10696 5 were be VBD cord-010092-uftc8inx 10696 6 typed type VBN cord-010092-uftc8inx 10696 7 heterozygous heterozygous JJ cord-010092-uftc8inx 10696 8 , , , cord-010092-uftc8inx 10696 9 IN:1,2 in:1,2 CD cord-010092-uftc8inx 10696 10 whereas whereas IN cord-010092-uftc8inx 10696 11 her -PRON- PRP$ cord-010092-uftc8inx 10696 12 husband husband NN cord-010092-uftc8inx 10696 13 was be VBD cord-010092-uftc8inx 10696 14 homozygous homozygous JJ cord-010092-uftc8inx 10696 15 , , , cord-010092-uftc8inx 10696 16 IN:-1,2 IN:-1,2 NNP cord-010092-uftc8inx 10696 17 . . . cord-010092-uftc8inx 10697 1 Due due IN cord-010092-uftc8inx 10697 2 to to IN cord-010092-uftc8inx 10697 3 the the DT cord-010092-uftc8inx 10697 4 husbands husband NNS cord-010092-uftc8inx 10697 5 phenotype phenotype NN cord-010092-uftc8inx 10697 6 , , , cord-010092-uftc8inx 10697 7 the the DT cord-010092-uftc8inx 10697 8 fetus fetus NN cord-010092-uftc8inx 10697 9 was be VBD cord-010092-uftc8inx 10697 10 predicted predict VBN cord-010092-uftc8inx 10697 11 to to TO cord-010092-uftc8inx 10697 12 be be VB cord-010092-uftc8inx 10697 13 In in IN cord-010092-uftc8inx 10697 14 b b NN cord-010092-uftc8inx 10697 15 positive positive JJ cord-010092-uftc8inx 10697 16 . . . cord-010092-uftc8inx 10698 1 Doppler Doppler NNP cord-010092-uftc8inx 10698 2 flow flow NN cord-010092-uftc8inx 10698 3 measurement measurement NN cord-010092-uftc8inx 10698 4 of of IN cord-010092-uftc8inx 10698 5 the the DT cord-010092-uftc8inx 10698 6 peak peak JJ cord-010092-uftc8inx 10698 7 systolic systolic JJ cord-010092-uftc8inx 10698 8 velocity velocity NN cord-010092-uftc8inx 10698 9 in in IN cord-010092-uftc8inx 10698 10 the the DT cord-010092-uftc8inx 10698 11 middle middle JJ cord-010092-uftc8inx 10698 12 cerebral cerebral JJ cord-010092-uftc8inx 10698 13 artery artery NN cord-010092-uftc8inx 10698 14 of of IN cord-010092-uftc8inx 10698 15 the the DT cord-010092-uftc8inx 10698 16 foetus foetus NN cord-010092-uftc8inx 10698 17 was be VBD cord-010092-uftc8inx 10698 18 normal normal JJ cord-010092-uftc8inx 10698 19 . . . cord-010092-uftc8inx 10699 1 Delivery delivery NN cord-010092-uftc8inx 10699 2 took take VBD cord-010092-uftc8inx 10699 3 place place NN cord-010092-uftc8inx 10699 4 at at IN cord-010092-uftc8inx 10699 5 GW GW NNP cord-010092-uftc8inx 10699 6 41 41 CD cord-010092-uftc8inx 10699 7 without without IN cord-010092-uftc8inx 10699 8 increased increase VBN cord-010092-uftc8inx 10699 9 bleeding bleed VBG cord-010092-uftc8inx 10699 10 . . . cord-010092-uftc8inx 10700 1 The the DT cord-010092-uftc8inx 10700 2 neonate neonate NN cord-010092-uftc8inx 10700 3 presented present VBD cord-010092-uftc8inx 10700 4 no no DT cord-010092-uftc8inx 10700 5 clinical clinical JJ cord-010092-uftc8inx 10700 6 manifestation manifestation NN cord-010092-uftc8inx 10700 7 of of IN cord-010092-uftc8inx 10700 8 HDFN HDFN NNP cord-010092-uftc8inx 10700 9 . . . cord-010092-uftc8inx 10701 1 Neither neither CC cord-010092-uftc8inx 10701 2 the the DT cord-010092-uftc8inx 10701 3 mother mother NN cord-010092-uftc8inx 10701 4 nor nor CC cord-010092-uftc8inx 10701 5 the the DT cord-010092-uftc8inx 10701 6 baby baby NN cord-010092-uftc8inx 10701 7 required require VBD cord-010092-uftc8inx 10701 8 blood blood NN cord-010092-uftc8inx 10701 9 transfusions transfusion NNS cord-010092-uftc8inx 10701 10 . . . cord-010092-uftc8inx 10702 1 Summary Summary NNP cord-010092-uftc8inx 10702 2 / / SYM cord-010092-uftc8inx 10702 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 10702 4 : : : cord-010092-uftc8inx 10703 1 We -PRON- PRP cord-010092-uftc8inx 10703 2 report report VBP cord-010092-uftc8inx 10703 3 the the DT cord-010092-uftc8inx 10703 4 case case NN cord-010092-uftc8inx 10703 5 of of IN cord-010092-uftc8inx 10703 6 a a DT cord-010092-uftc8inx 10703 7 pregnant pregnant JJ cord-010092-uftc8inx 10703 8 woman woman NN cord-010092-uftc8inx 10703 9 of of IN cord-010092-uftc8inx 10703 10 Indian indian JJ cord-010092-uftc8inx 10703 11 origin origin NN cord-010092-uftc8inx 10703 12 with with IN cord-010092-uftc8inx 10703 13 an an DT cord-010092-uftc8inx 10703 14 anti anti NN cord-010092-uftc8inx 10703 15 - - NN cord-010092-uftc8inx 10703 16 In in JJ cord-010092-uftc8inx 10703 17 b b NN cord-010092-uftc8inx 10703 18 alloantibody alloantibody NN cord-010092-uftc8inx 10703 19 . . . cord-010092-uftc8inx 10704 1 The the DT cord-010092-uftc8inx 10704 2 first first JJ cord-010092-uftc8inx 10704 3 MMA MMA NNP cord-010092-uftc8inx 10704 4 , , , cord-010092-uftc8inx 10704 5 performed perform VBN cord-010092-uftc8inx 10704 6 in in IN cord-010092-uftc8inx 10704 7 GW GW NNP cord-010092-uftc8inx 10704 8 32 32 CD cord-010092-uftc8inx 10704 9 , , , cord-010092-uftc8inx 10704 10 was be VBD cord-010092-uftc8inx 10704 11 inconclusive inconclusive JJ cord-010092-uftc8inx 10704 12 whereas whereas IN cord-010092-uftc8inx 10704 13 the the DT cord-010092-uftc8inx 10704 14 second second JJ cord-010092-uftc8inx 10704 15 MMA MMA NNP cord-010092-uftc8inx 10704 16 , , , cord-010092-uftc8inx 10704 17 performed perform VBN cord-010092-uftc8inx 10704 18 in in IN cord-010092-uftc8inx 10704 19 GW GW NNP cord-010092-uftc8inx 10704 20 36 36 CD cord-010092-uftc8inx 10704 21 , , , cord-010092-uftc8inx 10704 22 indicated indicate VBD cord-010092-uftc8inx 10704 23 that that IN cord-010092-uftc8inx 10704 24 the the DT cord-010092-uftc8inx 10704 25 antibody antibody NN cord-010092-uftc8inx 10704 26 was be VBD cord-010092-uftc8inx 10704 27 clinically clinically RB cord-010092-uftc8inx 10704 28 significant significant JJ cord-010092-uftc8inx 10704 29 . . . cord-010092-uftc8inx 10705 1 If if IN cord-010092-uftc8inx 10705 2 the the DT cord-010092-uftc8inx 10705 3 MI mi NN cord-010092-uftc8inx 10705 4 - - HYPH cord-010092-uftc8inx 10705 5 increase increase NN cord-010092-uftc8inx 10705 6 is be VBZ cord-010092-uftc8inx 10705 7 only only RB cord-010092-uftc8inx 10705 8 due due IN cord-010092-uftc8inx 10705 9 to to IN cord-010092-uftc8inx 10705 10 the the DT cord-010092-uftc8inx 10705 11 pregnancy pregnancy NN cord-010092-uftc8inx 10705 12 or or CC cord-010092-uftc8inx 10705 13 has have VBZ cord-010092-uftc8inx 10705 14 also also RB cord-010092-uftc8inx 10705 15 a a DT cord-010092-uftc8inx 10705 16 clinical clinical JJ cord-010092-uftc8inx 10705 17 significance significance NN cord-010092-uftc8inx 10705 18 , , , cord-010092-uftc8inx 10705 19 can can MD cord-010092-uftc8inx 10705 20 not not RB cord-010092-uftc8inx 10705 21 be be VB cord-010092-uftc8inx 10705 22 stated state VBN cord-010092-uftc8inx 10705 23 . . . cord-010092-uftc8inx 10706 1 In in IN cord-010092-uftc8inx 10706 2 b b LS cord-010092-uftc8inx 10706 3 negative negative JJ cord-010092-uftc8inx 10706 4 blood blood NN cord-010092-uftc8inx 10706 5 components component NNS cord-010092-uftc8inx 10706 6 were be VBD cord-010092-uftc8inx 10706 7 not not RB cord-010092-uftc8inx 10706 8 available available JJ cord-010092-uftc8inx 10706 9 and and CC cord-010092-uftc8inx 10706 10 the the DT cord-010092-uftc8inx 10706 11 patient patient NN cord-010092-uftc8inx 10706 12 's 's POS cord-010092-uftc8inx 10706 13 relatives relative NNS cord-010092-uftc8inx 10706 14 were be VBD cord-010092-uftc8inx 10706 15 all all DT cord-010092-uftc8inx 10706 16 In in IN cord-010092-uftc8inx 10706 17 b b NN cord-010092-uftc8inx 10706 18 positive positive JJ cord-010092-uftc8inx 10706 19 . . . cord-010092-uftc8inx 10707 1 Therefore therefore RB cord-010092-uftc8inx 10707 2 , , , cord-010092-uftc8inx 10707 3 measures measure NNS cord-010092-uftc8inx 10707 4 to to TO cord-010092-uftc8inx 10707 5 avoid avoid VB cord-010092-uftc8inx 10707 6 transfusions transfusion NNS cord-010092-uftc8inx 10707 7 , , , cord-010092-uftc8inx 10707 8 including include VBG cord-010092-uftc8inx 10707 9 optimised optimise VBN cord-010092-uftc8inx 10707 10 peripartal peripartal NNP cord-010092-uftc8inx 10707 11 management management NNP cord-010092-uftc8inx 10707 12 of of IN cord-010092-uftc8inx 10707 13 haemostasis haemostasis NNP cord-010092-uftc8inx 10707 14 , , , cord-010092-uftc8inx 10707 15 was be VBD cord-010092-uftc8inx 10707 16 of of IN cord-010092-uftc8inx 10707 17 utmost utmost JJ cord-010092-uftc8inx 10707 18 importance importance NN cord-010092-uftc8inx 10707 19 . . . cord-010092-uftc8inx 10708 1 With with IN cord-010092-uftc8inx 10708 2 only only RB cord-010092-uftc8inx 10708 3 few few JJ cord-010092-uftc8inx 10708 4 cases case NNS cord-010092-uftc8inx 10708 5 published publish VBN cord-010092-uftc8inx 10708 6 , , , cord-010092-uftc8inx 10708 7 the the DT cord-010092-uftc8inx 10708 8 risk risk NN cord-010092-uftc8inx 10708 9 of of IN cord-010092-uftc8inx 10708 10 HDFN HDFN NNP cord-010092-uftc8inx 10708 11 could could MD cord-010092-uftc8inx 10708 12 not not RB cord-010092-uftc8inx 10708 13 be be VB cord-010092-uftc8inx 10708 14 excluded exclude VBN cord-010092-uftc8inx 10708 15 with with IN cord-010092-uftc8inx 10708 16 certainty certainty NN cord-010092-uftc8inx 10708 17 . . . cord-010092-uftc8inx 10709 1 An an DT cord-010092-uftc8inx 10709 2 intrauterine intrauterine JJ cord-010092-uftc8inx 10709 3 investigation investigation NN cord-010092-uftc8inx 10709 4 by by IN cord-010092-uftc8inx 10709 5 Doppler Doppler NNP cord-010092-uftc8inx 10709 6 was be VBD cord-010092-uftc8inx 10709 7 performed perform VBN cord-010092-uftc8inx 10709 8 to to TO cord-010092-uftc8inx 10709 9 exclude exclude VB cord-010092-uftc8inx 10709 10 relevant relevant JJ cord-010092-uftc8inx 10709 11 anaemia anaemia NN cord-010092-uftc8inx 10709 12 of of IN cord-010092-uftc8inx 10709 13 the the DT cord-010092-uftc8inx 10709 14 fetus fetus NN cord-010092-uftc8inx 10709 15 . . . cord-010092-uftc8inx 10710 1 No no DT cord-010092-uftc8inx 10710 2 transfusion transfusion NN cord-010092-uftc8inx 10710 3 was be VBD cord-010092-uftc8inx 10710 4 needed need VBN cord-010092-uftc8inx 10710 5 at at IN cord-010092-uftc8inx 10710 6 delivery delivery NN cord-010092-uftc8inx 10710 7 as as IN cord-010092-uftc8inx 10710 8 there there EX cord-010092-uftc8inx 10710 9 were be VBD cord-010092-uftc8inx 10710 10 no no DT cord-010092-uftc8inx 10710 11 haemorrhagic haemorrhagic JJ cord-010092-uftc8inx 10710 12 complications complication NNS cord-010092-uftc8inx 10710 13 . . . cord-010092-uftc8inx 10711 1 The the DT cord-010092-uftc8inx 10711 2 neonate neonate NN cord-010092-uftc8inx 10711 3 presented present VBD cord-010092-uftc8inx 10711 4 no no DT cord-010092-uftc8inx 10711 5 clinical clinical JJ cord-010092-uftc8inx 10711 6 signs sign NNS cord-010092-uftc8inx 10711 7 of of IN cord-010092-uftc8inx 10711 8 HDFN HDFN NNP cord-010092-uftc8inx 10711 9 . . . cord-010092-uftc8inx 10712 1 Background background NN cord-010092-uftc8inx 10712 2 : : : cord-010092-uftc8inx 10713 1 Hemolytic hemolytic JJ cord-010092-uftc8inx 10713 2 disease disease NN cord-010092-uftc8inx 10713 3 of of IN cord-010092-uftc8inx 10713 4 the the DT cord-010092-uftc8inx 10713 5 fetus fetus NN cord-010092-uftc8inx 10713 6 and and CC cord-010092-uftc8inx 10713 7 newborn newborn JJ cord-010092-uftc8inx 10713 8 ( ( -LRB- cord-010092-uftc8inx 10713 9 HDFN HDFN NNP cord-010092-uftc8inx 10713 10 ) ) -RRB- cord-010092-uftc8inx 10713 11 is be VBZ cord-010092-uftc8inx 10713 12 a a DT cord-010092-uftc8inx 10713 13 disease disease NN cord-010092-uftc8inx 10713 14 which which WDT cord-010092-uftc8inx 10713 15 if if IN cord-010092-uftc8inx 10713 16 untreatedcan untreatedcan NNP cord-010092-uftc8inx 10713 17 cause cause VB cord-010092-uftc8inx 10713 18 perinatal perinatal JJ cord-010092-uftc8inx 10713 19 mortality mortality NN cord-010092-uftc8inx 10713 20 and and CC cord-010092-uftc8inx 10713 21 morbidity morbidity NN cord-010092-uftc8inx 10713 22 with with IN cord-010092-uftc8inx 10713 23 a a DT cord-010092-uftc8inx 10713 24 substantial substantial JJ cord-010092-uftc8inx 10713 25 risk risk NN cord-010092-uftc8inx 10713 26 for for IN cord-010092-uftc8inx 10713 27 long long JJ cord-010092-uftc8inx 10713 28 - - HYPH cord-010092-uftc8inx 10713 29 term term NN cord-010092-uftc8inx 10713 30 sequela sequela NN cord-010092-uftc8inx 10713 31 . . . cord-010092-uftc8inx 10714 1 In in IN cord-010092-uftc8inx 10714 2 Albania Albania NNP cord-010092-uftc8inx 10714 3 we -PRON- PRP cord-010092-uftc8inx 10714 4 lack lack VBP cord-010092-uftc8inx 10714 5 of of IN cord-010092-uftc8inx 10714 6 studies study NNS cord-010092-uftc8inx 10714 7 in in IN cord-010092-uftc8inx 10714 8 this this DT cord-010092-uftc8inx 10714 9 field field NN cord-010092-uftc8inx 10714 10 . . . cord-010092-uftc8inx 10715 1 Aims aim VBZ cord-010092-uftc8inx 10715 2 : : : cord-010092-uftc8inx 10716 1 The the DT cord-010092-uftc8inx 10716 2 aim aim NN cord-010092-uftc8inx 10716 3 of of IN cord-010092-uftc8inx 10716 4 this this DT cord-010092-uftc8inx 10716 5 study study NN cord-010092-uftc8inx 10716 6 is be VBZ cord-010092-uftc8inx 10716 7 to to TO cord-010092-uftc8inx 10716 8 determine determine VB cord-010092-uftc8inx 10716 9 the the DT cord-010092-uftc8inx 10716 10 predictive predictive JJ cord-010092-uftc8inx 10716 11 value value NN cord-010092-uftc8inx 10716 12 and and CC cord-010092-uftc8inx 10716 13 the the DT cord-010092-uftc8inx 10716 14 reliability reliability NN cord-010092-uftc8inx 10716 15 of of IN cord-010092-uftc8inx 10716 16 the the DT cord-010092-uftc8inx 10716 17 " " `` cord-010092-uftc8inx 10716 18 critical critical JJ cord-010092-uftc8inx 10716 19 titre titre NN cord-010092-uftc8inx 10716 20 " " '' cord-010092-uftc8inx 10716 21 during during IN cord-010092-uftc8inx 10716 22 the the DT cord-010092-uftc8inx 10716 23 evaluation evaluation NN cord-010092-uftc8inx 10716 24 of of IN cord-010092-uftc8inx 10716 25 red red JJ cord-010092-uftc8inx 10716 26 cells cell NNS cord-010092-uftc8inx 10716 27 alloantibodies alloantibody NNS cord-010092-uftc8inx 10716 28 ability ability NN cord-010092-uftc8inx 10716 29 to to TO cord-010092-uftc8inx 10716 30 cause cause VB cord-010092-uftc8inx 10716 31 the the DT cord-010092-uftc8inx 10716 32 Hemolytic hemolytic JJ cord-010092-uftc8inx 10716 33 Disease Disease NNP cord-010092-uftc8inx 10716 34 of of IN cord-010092-uftc8inx 10716 35 Fetus Fetus NNP cord-010092-uftc8inx 10716 36 and and CC cord-010092-uftc8inx 10716 37 Newborn Newborn NNP cord-010092-uftc8inx 10716 38 . . . cord-010092-uftc8inx 10717 1 Methods method NNS cord-010092-uftc8inx 10717 2 : : : cord-010092-uftc8inx 10718 1 We -PRON- PRP cord-010092-uftc8inx 10718 2 conducted conduct VBD cord-010092-uftc8inx 10718 3 a a DT cord-010092-uftc8inx 10718 4 descriptive descriptive JJ cord-010092-uftc8inx 10718 5 , , , cord-010092-uftc8inx 10718 6 cross cross JJ cord-010092-uftc8inx 10718 7 - - JJ cord-010092-uftc8inx 10718 8 sectional sectional JJ cord-010092-uftc8inx 10718 9 study study NN cord-010092-uftc8inx 10718 10 . . . cord-010092-uftc8inx 10719 1 The the DT cord-010092-uftc8inx 10719 2 data datum NNS cord-010092-uftc8inx 10719 3 were be VBD cord-010092-uftc8inx 10719 4 collected collect VBN cord-010092-uftc8inx 10719 5 in in IN cord-010092-uftc8inx 10719 6 the the DT cord-010092-uftc8inx 10719 7 University University NNP cord-010092-uftc8inx 10719 8 Hospital Hospital NNP cord-010092-uftc8inx 10719 9 for for IN cord-010092-uftc8inx 10719 10 Obstetrics Obstetrics NNP cord-010092-uftc8inx 10719 11 and and CC cord-010092-uftc8inx 10719 12 Gynecology Gynecology NNP cord-010092-uftc8inx 10719 13 in in IN cord-010092-uftc8inx 10719 14 Albania Albania NNP cord-010092-uftc8inx 10719 15 . . . cord-010092-uftc8inx 10720 1 In in IN cord-010092-uftc8inx 10720 2 the the DT cord-010092-uftc8inx 10720 3 study study NN cord-010092-uftc8inx 10720 4 were be VBD cord-010092-uftc8inx 10720 5 included include VBN cord-010092-uftc8inx 10720 6 20 20 CD cord-010092-uftc8inx 10720 7 immunized immunize VBN cord-010092-uftc8inx 10720 8 pregnant pregnant JJ cord-010092-uftc8inx 10720 9 woman woman NN cord-010092-uftc8inx 10720 10 for for IN cord-010092-uftc8inx 10720 11 anti anti JJ cord-010092-uftc8inx 10720 12 - - JJ cord-010092-uftc8inx 10720 13 D d JJ cord-010092-uftc8inx 10720 14 antibodies antibody NNS cord-010092-uftc8inx 10720 15 and and CC cord-010092-uftc8inx 10720 16 their -PRON- PRP$ cord-010092-uftc8inx 10720 17 newborns newborn NNS cord-010092-uftc8inx 10720 18 which which WDT cord-010092-uftc8inx 10720 19 were be VBD cord-010092-uftc8inx 10720 20 affected affect VBN cord-010092-uftc8inx 10720 21 from from IN cord-010092-uftc8inx 10720 22 the the DT cord-010092-uftc8inx 10720 23 Hemolytic hemolytic JJ cord-010092-uftc8inx 10720 24 Disease Disease NNP cord-010092-uftc8inx 10720 25 of of IN cord-010092-uftc8inx 10720 26 Fetus Fetus NNP cord-010092-uftc8inx 10720 27 and and CC cord-010092-uftc8inx 10720 28 Newborn Newborn NNP cord-010092-uftc8inx 10720 29 . . . cord-010092-uftc8inx 10721 1 The the DT cord-010092-uftc8inx 10721 2 data datum NNS cord-010092-uftc8inx 10721 3 belong belong VBP cord-010092-uftc8inx 10721 4 to to IN cord-010092-uftc8inx 10721 5 the the DT cord-010092-uftc8inx 10721 6 period period NN cord-010092-uftc8inx 10721 7 2013 2013 CD cord-010092-uftc8inx 10721 8 and and CC cord-010092-uftc8inx 10721 9 2018 2018 CD cord-010092-uftc8inx 10721 10 . . . cord-010092-uftc8inx 10722 1 Results result NNS cord-010092-uftc8inx 10722 2 : : : cord-010092-uftc8inx 10723 1 The the DT cord-010092-uftc8inx 10723 2 " " `` cord-010092-uftc8inx 10723 3 Critical Critical NNP cord-010092-uftc8inx 10723 4 Titre Titre NNP cord-010092-uftc8inx 10723 5 " " '' cord-010092-uftc8inx 10723 6 in in IN cord-010092-uftc8inx 10723 7 our -PRON- PRP$ cord-010092-uftc8inx 10723 8 study study NN cord-010092-uftc8inx 10723 9 was be VBD cord-010092-uftc8inx 10723 10 8 8 CD cord-010092-uftc8inx 10723 11 , , , cord-010092-uftc8inx 10723 12 meaning mean VBG cord-010092-uftc8inx 10723 13 that that IN cord-010092-uftc8inx 10723 14 this this DT cord-010092-uftc8inx 10723 15 was be VBD cord-010092-uftc8inx 10723 16 the the DT cord-010092-uftc8inx 10723 17 minimal minimal JJ cord-010092-uftc8inx 10723 18 value value NN cord-010092-uftc8inx 10723 19 of of IN cord-010092-uftc8inx 10723 20 the the DT cord-010092-uftc8inx 10723 21 titre titre NN cord-010092-uftc8inx 10723 22 antibodies antibody NNS cord-010092-uftc8inx 10723 23 that that WDT cord-010092-uftc8inx 10723 24 could could MD cord-010092-uftc8inx 10723 25 cause cause VB cord-010092-uftc8inx 10723 26 Hemolytic hemolytic JJ cord-010092-uftc8inx 10723 27 Disease Disease NNP cord-010092-uftc8inx 10723 28 of of IN cord-010092-uftc8inx 10723 29 Fetus Fetus NNP cord-010092-uftc8inx 10723 30 and and CC cord-010092-uftc8inx 10723 31 Newborn Newborn NNP cord-010092-uftc8inx 10723 32 . . . cord-010092-uftc8inx 10724 1 Our -PRON- PRP$ cord-010092-uftc8inx 10724 2 study study NN cord-010092-uftc8inx 10724 3 concluded conclude VBD cord-010092-uftc8inx 10724 4 that that IN cord-010092-uftc8inx 10724 5 only only RB cord-010092-uftc8inx 10724 6 2 2 CD cord-010092-uftc8inx 10724 7 newborns newborn NNS cord-010092-uftc8inx 10724 8 were be VBD cord-010092-uftc8inx 10724 9 born bear VBN cord-010092-uftc8inx 10724 10 without without IN cord-010092-uftc8inx 10724 11 the the DT cord-010092-uftc8inx 10724 12 Hemolytic hemolytic JJ cord-010092-uftc8inx 10724 13 Disease Disease NNP cord-010092-uftc8inx 10724 14 of of IN cord-010092-uftc8inx 10724 15 Fetus Fetus NNP cord-010092-uftc8inx 10724 16 and and CC cord-010092-uftc8inx 10724 17 Newborn Newborn NNP cord-010092-uftc8inx 10724 18 and and CC cord-010092-uftc8inx 10724 19 the the DT cord-010092-uftc8inx 10724 20 titre titre NN cord-010092-uftc8inx 10724 21 values value NNS cord-010092-uftc8inx 10724 22 were be VBD cord-010092-uftc8inx 10724 23 less less JJR cord-010092-uftc8inx 10724 24 than than IN cord-010092-uftc8inx 10724 25 4 4 CD cord-010092-uftc8inx 10724 26 . . . cord-010092-uftc8inx 10725 1 Moderate moderate JJ cord-010092-uftc8inx 10725 2 Hemolytic hemolytic JJ cord-010092-uftc8inx 10725 3 Disease Disease NNP cord-010092-uftc8inx 10725 4 of of IN cord-010092-uftc8inx 10725 5 Fetus Fetus NNP cord-010092-uftc8inx 10725 6 and and CC cord-010092-uftc8inx 10725 7 Newborn Newborn NNP cord-010092-uftc8inx 10725 8 were be VBD cord-010092-uftc8inx 10725 9 caused cause VBN cord-010092-uftc8inx 10725 10 between between IN cord-010092-uftc8inx 10725 11 the the DT cord-010092-uftc8inx 10725 12 titre titre NN cord-010092-uftc8inx 10725 13 values value NNS cord-010092-uftc8inx 10725 14 8 8 CD cord-010092-uftc8inx 10725 15 - - SYM cord-010092-uftc8inx 10725 16 32 32 CD cord-010092-uftc8inx 10725 17 . . . cord-010092-uftc8inx 10726 1 The the DT cord-010092-uftc8inx 10726 2 Summary Summary NNP cord-010092-uftc8inx 10726 3 / / SYM cord-010092-uftc8inx 10726 4 Conclusions Conclusions NNPS cord-010092-uftc8inx 10726 5 : : : cord-010092-uftc8inx 10727 1 The the DT cord-010092-uftc8inx 10727 2 titre titre NN cord-010092-uftc8inx 10727 3 values value NNS cord-010092-uftc8inx 10727 4 of of IN cord-010092-uftc8inx 10727 5 the the DT cord-010092-uftc8inx 10727 6 mothers mother NNS cord-010092-uftc8inx 10727 7 are be VBP cord-010092-uftc8inx 10727 8 a a DT cord-010092-uftc8inx 10727 9 predictive predictive JJ cord-010092-uftc8inx 10727 10 option option NN cord-010092-uftc8inx 10727 11 of of IN cord-010092-uftc8inx 10727 12 the the DT cord-010092-uftc8inx 10727 13 high high JJ cord-010092-uftc8inx 10727 14 risk risk NN cord-010092-uftc8inx 10727 15 of of IN cord-010092-uftc8inx 10727 16 giving give VBG cord-010092-uftc8inx 10727 17 birth birth NN cord-010092-uftc8inx 10727 18 to to IN cord-010092-uftc8inx 10727 19 a a DT cord-010092-uftc8inx 10727 20 child child NN cord-010092-uftc8inx 10727 21 with with IN cord-010092-uftc8inx 10727 22 the the DT cord-010092-uftc8inx 10727 23 Hemolytic hemolytic JJ cord-010092-uftc8inx 10727 24 Disease Disease NNP cord-010092-uftc8inx 10727 25 of of IN cord-010092-uftc8inx 10727 26 Fetus Fetus NNP cord-010092-uftc8inx 10727 27 and and CC cord-010092-uftc8inx 10727 28 Newborn Newborn NNP cord-010092-uftc8inx 10727 29 . . . cord-010092-uftc8inx 10728 1 It -PRON- PRP cord-010092-uftc8inx 10728 2 is be VBZ cord-010092-uftc8inx 10728 3 recommended recommend VBN cord-010092-uftc8inx 10728 4 that that IN cord-010092-uftc8inx 10728 5 in in IN cord-010092-uftc8inx 10728 6 this this DT cord-010092-uftc8inx 10728 7 cases case NNS cord-010092-uftc8inx 10728 8 the the DT cord-010092-uftc8inx 10728 9 mother mother NN cord-010092-uftc8inx 10728 10 should should MD cord-010092-uftc8inx 10728 11 be be VB cord-010092-uftc8inx 10728 12 followed follow VBN cord-010092-uftc8inx 10728 13 with with IN cord-010092-uftc8inx 10728 14 Doppler Doppler NNP cord-010092-uftc8inx 10728 15 Ultrasonography Ultrasonography NNP cord-010092-uftc8inx 10728 16 to to TO cord-010092-uftc8inx 10728 17 measure measure VB cord-010092-uftc8inx 10728 18 the the DT cord-010092-uftc8inx 10728 19 blood blood NN cord-010092-uftc8inx 10728 20 flow flow NN cord-010092-uftc8inx 10728 21 of of IN cord-010092-uftc8inx 10728 22 the the DT cord-010092-uftc8inx 10728 23 middle middle JJ cord-010092-uftc8inx 10728 24 cerebral cerebral JJ cord-010092-uftc8inx 10728 25 artery artery NN cord-010092-uftc8inx 10728 26 . . . cord-010092-uftc8inx 10729 1 Also also RB cord-010092-uftc8inx 10729 2 the the DT cord-010092-uftc8inx 10729 3 doctors doctor NNS cord-010092-uftc8inx 10729 4 should should MD cord-010092-uftc8inx 10729 5 recommend recommend VB cord-010092-uftc8inx 10729 6 in in IN cord-010092-uftc8inx 10729 7 pregnant pregnant JJ cord-010092-uftc8inx 10729 8 women woman NNS cord-010092-uftc8inx 10729 9 with with IN cord-010092-uftc8inx 10729 10 positive positive JJ cord-010092-uftc8inx 10729 11 Coombs Coombs NNP cord-010092-uftc8inx 10729 12 test test NN cord-010092-uftc8inx 10729 13 not not RB cord-010092-uftc8inx 10729 14 only only RB cord-010092-uftc8inx 10729 15 the the DT cord-010092-uftc8inx 10729 16 identification identification NN cord-010092-uftc8inx 10729 17 of of IN cord-010092-uftc8inx 10729 18 the the DT cord-010092-uftc8inx 10729 19 anti anti JJ cord-010092-uftc8inx 10729 20 - - JJ cord-010092-uftc8inx 10729 21 D d JJ cord-010092-uftc8inx 10729 22 antibodies antibody NNS cord-010092-uftc8inx 10729 23 but but CC cord-010092-uftc8inx 10729 24 also also RB cord-010092-uftc8inx 10729 25 the the DT cord-010092-uftc8inx 10729 26 identification identification NN cord-010092-uftc8inx 10729 27 of of IN cord-010092-uftc8inx 10729 28 the the DT cord-010092-uftc8inx 10729 29 other other JJ cord-010092-uftc8inx 10729 30 antibodies antibody NNS cord-010092-uftc8inx 10729 31 such such JJ cord-010092-uftc8inx 10729 32 as as IN cord-010092-uftc8inx 10729 33 anti anti JJ cord-010092-uftc8inx 10729 34 - - JJ cord-010092-uftc8inx 10729 35 E e JJ cord-010092-uftc8inx 10729 36 , , , cord-010092-uftc8inx 10729 37 anti anti JJ cord-010092-uftc8inx 10729 38 - - NN cord-010092-uftc8inx 10729 39 c c JJ cord-010092-uftc8inx 10729 40 , , , cord-010092-uftc8inx 10729 41 anti anti NNP cord-010092-uftc8inx 10729 42 - - NNP cord-010092-uftc8inx 10729 43 K. K. NNP cord-010092-uftc8inx 10729 44 Background background NN cord-010092-uftc8inx 10729 45 : : : cord-010092-uftc8inx 10729 46 RhD rhd NN cord-010092-uftc8inx 10729 47 - - HYPH cord-010092-uftc8inx 10729 48 negative negative JJ cord-010092-uftc8inx 10729 49 pregnant pregnant JJ cord-010092-uftc8inx 10729 50 women woman NNS cord-010092-uftc8inx 10729 51 with with IN cord-010092-uftc8inx 10729 52 allo allo NN cord-010092-uftc8inx 10729 53 - - HYPH cord-010092-uftc8inx 10729 54 anti anti NN cord-010092-uftc8inx 10729 55 - - JJ cord-010092-uftc8inx 10729 56 D d JJ cord-010092-uftc8inx 10729 57 are be VBP cord-010092-uftc8inx 10729 58 at at IN cord-010092-uftc8inx 10729 59 risk risk NN cord-010092-uftc8inx 10729 60 of of IN cord-010092-uftc8inx 10729 61 having have VBG cord-010092-uftc8inx 10729 62 a a DT cord-010092-uftc8inx 10729 63 fetus fetus NN cord-010092-uftc8inx 10729 64 affected affect VBN cord-010092-uftc8inx 10729 65 by by IN cord-010092-uftc8inx 10729 66 haemolytic haemolytic JJ cord-010092-uftc8inx 10729 67 disease disease NN cord-010092-uftc8inx 10729 68 of of IN cord-010092-uftc8inx 10729 69 the the DT cord-010092-uftc8inx 10729 70 fetus fetus NN cord-010092-uftc8inx 10729 71 and and CC cord-010092-uftc8inx 10729 72 newborn newborn JJ cord-010092-uftc8inx 10729 73 ( ( -LRB- cord-010092-uftc8inx 10729 74 HDFN HDFN NNP cord-010092-uftc8inx 10729 75 ) ) -RRB- cord-010092-uftc8inx 10729 76 where where WRB cord-010092-uftc8inx 10729 77 the the DT cord-010092-uftc8inx 10729 78 fetus fetus NN cord-010092-uftc8inx 10729 79 is be VBZ cord-010092-uftc8inx 10729 80 RhD rhd NN cord-010092-uftc8inx 10729 81 - - HYPH cord-010092-uftc8inx 10729 82 positive positive JJ cord-010092-uftc8inx 10729 83 . . . cord-010092-uftc8inx 10730 1 The the DT cord-010092-uftc8inx 10730 2 RHD RHD NNP cord-010092-uftc8inx 10730 3 allele allele NN cord-010092-uftc8inx 10730 4 is be VBZ cord-010092-uftc8inx 10730 5 highly highly RB cord-010092-uftc8inx 10730 6 polymorphic polymorphic JJ cord-010092-uftc8inx 10730 7 and and CC cord-010092-uftc8inx 10730 8 many many JJ cord-010092-uftc8inx 10730 9 RHD RHD NNP cord-010092-uftc8inx 10730 10 variants variant NNS cord-010092-uftc8inx 10730 11 give give VBP cord-010092-uftc8inx 10730 12 rise rise NN cord-010092-uftc8inx 10730 13 to to IN cord-010092-uftc8inx 10730 14 an an DT cord-010092-uftc8inx 10730 15 array array NN cord-010092-uftc8inx 10730 16 of of IN cord-010092-uftc8inx 10730 17 partial partial JJ cord-010092-uftc8inx 10730 18 D d NN cord-010092-uftc8inx 10730 19 phenotypes phenotype NNS cord-010092-uftc8inx 10730 20 . . . cord-010092-uftc8inx 10731 1 The the DT cord-010092-uftc8inx 10731 2 clinical clinical JJ cord-010092-uftc8inx 10731 3 significance significance NN cord-010092-uftc8inx 10731 4 for for IN cord-010092-uftc8inx 10731 5 many many JJ cord-010092-uftc8inx 10731 6 partial partial JJ cord-010092-uftc8inx 10731 7 D d NN cord-010092-uftc8inx 10731 8 phenotypes phenotype NNS cord-010092-uftc8inx 10731 9 is be VBZ cord-010092-uftc8inx 10731 10 not not RB cord-010092-uftc8inx 10731 11 well well RB cord-010092-uftc8inx 10731 12 - - HYPH cord-010092-uftc8inx 10731 13 established establish VBN cord-010092-uftc8inx 10731 14 . . . cord-010092-uftc8inx 10732 1 RHD RHD NNP cord-010092-uftc8inx 10732 2 genotyping genotyping NN cord-010092-uftc8inx 10732 3 by by IN cord-010092-uftc8inx 10732 4 Non non JJ cord-010092-uftc8inx 10732 5 - - JJ cord-010092-uftc8inx 10732 6 invasive invasive JJ cord-010092-uftc8inx 10732 7 Prenatal prenatal JJ cord-010092-uftc8inx 10732 8 Testing testing NN cord-010092-uftc8inx 10732 9 ( ( -LRB- cord-010092-uftc8inx 10732 10 NIPT NIPT NNP cord-010092-uftc8inx 10732 11 ) ) -RRB- cord-010092-uftc8inx 10733 1 to to TO cord-010092-uftc8inx 10733 2 assess assess VB cord-010092-uftc8inx 10733 3 the the DT cord-010092-uftc8inx 10733 4 fetal fetal JJ cord-010092-uftc8inx 10733 5 RHD rhd NN cord-010092-uftc8inx 10733 6 status status NN cord-010092-uftc8inx 10733 7 determines determine VBZ cord-010092-uftc8inx 10733 8 whether whether IN cord-010092-uftc8inx 10733 9 the the DT cord-010092-uftc8inx 10733 10 fetus fetus NN cord-010092-uftc8inx 10733 11 is be VBZ cord-010092-uftc8inx 10733 12 at at IN cord-010092-uftc8inx 10733 13 risk risk NN cord-010092-uftc8inx 10733 14 for for IN cord-010092-uftc8inx 10733 15 HDFN HDFN NNP cord-010092-uftc8inx 10733 16 . . . cord-010092-uftc8inx 10734 1 NIPT NIPT NNP cord-010092-uftc8inx 10734 2 tests test NNS cord-010092-uftc8inx 10734 3 also also RB cord-010092-uftc8inx 10734 4 include include VBP cord-010092-uftc8inx 10734 5 strategies strategy NNS cord-010092-uftc8inx 10734 6 for for IN cord-010092-uftc8inx 10734 7 detecting detect VBG cord-010092-uftc8inx 10734 8 maternal maternal JJ cord-010092-uftc8inx 10734 9 RHD RHD NNP cord-010092-uftc8inx 10734 10 variants variant NNS cord-010092-uftc8inx 10734 11 to to TO cord-010092-uftc8inx 10734 12 provide provide VB cord-010092-uftc8inx 10734 13 for for IN cord-010092-uftc8inx 10734 14 accurate accurate JJ cord-010092-uftc8inx 10734 15 reporting reporting NN cord-010092-uftc8inx 10734 16 . . . cord-010092-uftc8inx 10735 1 However however RB cord-010092-uftc8inx 10735 2 , , , cord-010092-uftc8inx 10735 3 the the DT cord-010092-uftc8inx 10735 4 presence presence NN cord-010092-uftc8inx 10735 5 of of IN cord-010092-uftc8inx 10735 6 a a DT cord-010092-uftc8inx 10735 7 paternal paternal JJ cord-010092-uftc8inx 10735 8 RHD rhd NN cord-010092-uftc8inx 10735 9 variant variant NN cord-010092-uftc8inx 10735 10 , , , cord-010092-uftc8inx 10735 11 while while IN cord-010092-uftc8inx 10735 12 having have VBG cord-010092-uftc8inx 10735 13 the the DT cord-010092-uftc8inx 10735 14 potential potential NN cord-010092-uftc8inx 10735 15 to to TO cord-010092-uftc8inx 10735 16 confound confound VB cord-010092-uftc8inx 10735 17 NIPT NIPT NNP cord-010092-uftc8inx 10735 18 interpretation interpretation NN cord-010092-uftc8inx 10735 19 , , , cord-010092-uftc8inx 10735 20 is be VBZ cord-010092-uftc8inx 10735 21 often often RB cord-010092-uftc8inx 10735 22 not not RB cord-010092-uftc8inx 10735 23 recognised recognise VBN cord-010092-uftc8inx 10735 24 . . . cord-010092-uftc8inx 10736 1 We -PRON- PRP cord-010092-uftc8inx 10736 2 report report VBP cord-010092-uftc8inx 10736 3 a a DT cord-010092-uftc8inx 10736 4 " " `` cord-010092-uftc8inx 10736 5 trio trio NN cord-010092-uftc8inx 10736 6 " " '' cord-010092-uftc8inx 10736 7 family family NN cord-010092-uftc8inx 10736 8 study study NN cord-010092-uftc8inx 10736 9 triggered trigger VBN cord-010092-uftc8inx 10736 10 by by IN cord-010092-uftc8inx 10736 11 a a DT cord-010092-uftc8inx 10736 12 request request NN cord-010092-uftc8inx 10736 13 for for IN cord-010092-uftc8inx 10736 14 NIPT NIPT NNP cord-010092-uftc8inx 10736 15 for for IN cord-010092-uftc8inx 10736 16 an an DT cord-010092-uftc8inx 10736 17 RhD rhd NN cord-010092-uftc8inx 10736 18 - - HYPH cord-010092-uftc8inx 10736 19 negative negative JJ cord-010092-uftc8inx 10736 20 pregnant pregnant JJ cord-010092-uftc8inx 10736 21 mother mother NN cord-010092-uftc8inx 10736 22 , , , cord-010092-uftc8inx 10736 23 16 16 CD cord-010092-uftc8inx 10736 24 weeks week NNS cord-010092-uftc8inx 10736 25 gestation gestation NN cord-010092-uftc8inx 10736 26 , , , cord-010092-uftc8inx 10736 27 who who WP cord-010092-uftc8inx 10736 28 presented present VBD cord-010092-uftc8inx 10736 29 with with IN cord-010092-uftc8inx 10736 30 allo allo NN cord-010092-uftc8inx 10736 31 - - HYPH cord-010092-uftc8inx 10736 32 anti anti NN cord-010092-uftc8inx 10736 33 - - JJ cord-010092-uftc8inx 10736 34 D d JJ cord-010092-uftc8inx 10736 35 and and CC cord-010092-uftc8inx 10736 36 anti anti JJ cord-010092-uftc8inx 10736 37 - - NN cord-010092-uftc8inx 10736 38 Jk Jk NNP cord-010092-uftc8inx 10736 39 a a DT cord-010092-uftc8inx 10736 40 antibody antibody NN cord-010092-uftc8inx 10736 41 . . . cord-010092-uftc8inx 10737 1 Subsequent subsequent JJ cord-010092-uftc8inx 10737 2 paternal paternal JJ cord-010092-uftc8inx 10737 3 and and CC cord-010092-uftc8inx 10737 4 fetal fetal JJ cord-010092-uftc8inx 10737 5 RHD rhd NN cord-010092-uftc8inx 10737 6 genotyping genotyping NN cord-010092-uftc8inx 10737 7 was be VBD cord-010092-uftc8inx 10737 8 conducted conduct VBN cord-010092-uftc8inx 10737 9 and and CC cord-010092-uftc8inx 10737 10 revealed reveal VBD cord-010092-uftc8inx 10737 11 a a DT cord-010092-uftc8inx 10737 12 novel novel JJ cord-010092-uftc8inx 10737 13 variant variant NN cord-010092-uftc8inx 10737 14 RHD RHD NNP cord-010092-uftc8inx 10737 15 allele allele NN cord-010092-uftc8inx 10737 16 . . . cord-010092-uftc8inx 10738 1 Aims aim VBZ cord-010092-uftc8inx 10738 2 : : : cord-010092-uftc8inx 10738 3 We -PRON- PRP cord-010092-uftc8inx 10738 4 aim aim VBP cord-010092-uftc8inx 10738 5 to to TO cord-010092-uftc8inx 10738 6 characterise characterise VB cord-010092-uftc8inx 10738 7 the the DT cord-010092-uftc8inx 10738 8 paternal paternal JJ cord-010092-uftc8inx 10738 9 RHD RHD NNP cord-010092-uftc8inx 10738 10 allele allele NN cord-010092-uftc8inx 10738 11 and and CC cord-010092-uftc8inx 10738 12 review review VB cord-010092-uftc8inx 10738 13 clinical clinical JJ cord-010092-uftc8inx 10738 14 case case NN cord-010092-uftc8inx 10738 15 features feature NNS cord-010092-uftc8inx 10738 16 . . . cord-010092-uftc8inx 10739 1 Methods method NNS cord-010092-uftc8inx 10739 2 : : : cord-010092-uftc8inx 10739 3 Rh Rh NNP cord-010092-uftc8inx 10739 4 phenotyping phenotyping NN cord-010092-uftc8inx 10739 5 was be VBD cord-010092-uftc8inx 10739 6 performed perform VBN cord-010092-uftc8inx 10739 7 by by IN cord-010092-uftc8inx 10739 8 standard standard JJ cord-010092-uftc8inx 10739 9 serological serological JJ cord-010092-uftc8inx 10739 10 procedures procedure NNS cord-010092-uftc8inx 10739 11 . . . cord-010092-uftc8inx 10740 1 NIPT NIPT NNP cord-010092-uftc8inx 10740 2 tested test VBN cord-010092-uftc8inx 10740 3 for for IN cord-010092-uftc8inx 10740 4 fetal fetal JJ cord-010092-uftc8inx 10740 5 RHD RHD NNP cord-010092-uftc8inx 10740 6 Exons Exons NNP cord-010092-uftc8inx 10740 7 4 4 CD cord-010092-uftc8inx 10740 8 , , , cord-010092-uftc8inx 10740 9 5 5 CD cord-010092-uftc8inx 10740 10 and and CC cord-010092-uftc8inx 10740 11 10 10 CD cord-010092-uftc8inx 10740 12 . . . cord-010092-uftc8inx 10741 1 RHD RHD NNP cord-010092-uftc8inx 10741 2 genotyping genotype VBG cord-010092-uftc8inx 10741 3 on on IN cord-010092-uftc8inx 10741 4 whole whole JJ cord-010092-uftc8inx 10741 5 blood blood NN cord-010092-uftc8inx 10741 6 / / SYM cord-010092-uftc8inx 10741 7 cord cord NN cord-010092-uftc8inx 10741 8 blood blood NN cord-010092-uftc8inx 10741 9 DNA DNA NNP cord-010092-uftc8inx 10741 10 was be VBD cord-010092-uftc8inx 10741 11 performed perform VBN cord-010092-uftc8inx 10741 12 on on IN cord-010092-uftc8inx 10741 13 the the DT cord-010092-uftc8inx 10741 14 Immucor Immucor NNP cord-010092-uftc8inx 10741 15 Bioarray Bioarray NNP cord-010092-uftc8inx 10741 16 RHD RHD NNP cord-010092-uftc8inx 10741 17 BeadChip BeadChip NNP cord-010092-uftc8inx 10741 18 kit kit NN cord-010092-uftc8inx 10741 19 which which WDT cord-010092-uftc8inx 10741 20 predicts predict VBZ cord-010092-uftc8inx 10741 21 a a DT cord-010092-uftc8inx 10741 22 RhD rhd NN cord-010092-uftc8inx 10741 23 phenotypic phenotypic NN cord-010092-uftc8inx 10741 24 variant variant NN cord-010092-uftc8inx 10741 25 of of IN cord-010092-uftc8inx 10741 26 best good JJS cord-010092-uftc8inx 10741 27 fit fit NN cord-010092-uftc8inx 10741 28 . . . cord-010092-uftc8inx 10742 1 DNA dna NN cord-010092-uftc8inx 10742 2 sequencing sequencing NN cord-010092-uftc8inx 10742 3 was be VBD cord-010092-uftc8inx 10742 4 performed perform VBN cord-010092-uftc8inx 10742 5 using use VBG cord-010092-uftc8inx 10742 6 the the DT cord-010092-uftc8inx 10742 7 Illumina Illumina NNP cord-010092-uftc8inx 10742 8 TruSight TruSight NNP cord-010092-uftc8inx 10742 9 One one CD cord-010092-uftc8inx 10742 10 Sequencing Sequencing NNP cord-010092-uftc8inx 10742 11 panel panel NN cord-010092-uftc8inx 10742 12 . . . cord-010092-uftc8inx 10743 1 Copy copy JJ cord-010092-uftc8inx 10743 2 number number NN cord-010092-uftc8inx 10743 3 variation variation NN cord-010092-uftc8inx 10743 4 ( ( -LRB- cord-010092-uftc8inx 10743 5 CNV CNV NNP cord-010092-uftc8inx 10743 6 ) ) -RRB- cord-010092-uftc8inx 10743 7 analysis analysis NN cord-010092-uftc8inx 10743 8 was be VBD cord-010092-uftc8inx 10743 9 used use VBN cord-010092-uftc8inx 10743 10 to to TO cord-010092-uftc8inx 10743 11 assess assess VB cord-010092-uftc8inx 10743 12 the the DT cord-010092-uftc8inx 10743 13 RHD RHD NNP cord-010092-uftc8inx 10743 14 exon exon NN cord-010092-uftc8inx 10743 15 structure structure NN cord-010092-uftc8inx 10743 16 and and CC cord-010092-uftc8inx 10743 17 zygosity zygosity NN cord-010092-uftc8inx 10743 18 . . . cord-010092-uftc8inx 10744 1 Results result NNS cord-010092-uftc8inx 10744 2 : : : cord-010092-uftc8inx 10745 1 The the DT cord-010092-uftc8inx 10745 2 paternal paternal JJ cord-010092-uftc8inx 10745 3 red red JJ cord-010092-uftc8inx 10745 4 cells cell NNS cord-010092-uftc8inx 10745 5 typed type VBN cord-010092-uftc8inx 10745 6 as as IN cord-010092-uftc8inx 10745 7 group group NN cord-010092-uftc8inx 10745 8 O o NN cord-010092-uftc8inx 10745 9 RhD+C RhD+C NNP cord-010092-uftc8inx 10745 10 - - HYPH cord-010092-uftc8inx 10745 11 c+E c+E NNP cord-010092-uftc8inx 10745 12 - - HYPH cord-010092-uftc8inx 10745 13 e+ e+ NNP cord-010092-uftc8inx 10745 14 , , , cord-010092-uftc8inx 10745 15 ( ( -LRB- cord-010092-uftc8inx 10745 16 Ror Ror NNP cord-010092-uftc8inx 10745 17 ) ) -RRB- cord-010092-uftc8inx 10745 18 . . . cord-010092-uftc8inx 10746 1 NIPT NIPT NNP cord-010092-uftc8inx 10746 2 genotyping genotype VBG cord-010092-uftc8inx 10746 3 detected detect VBD cord-010092-uftc8inx 10746 4 fetal fetal JJ cord-010092-uftc8inx 10746 5 RHD rhd NN cord-010092-uftc8inx 10746 6 signals signal NNS cord-010092-uftc8inx 10746 7 for for IN cord-010092-uftc8inx 10746 8 all all DT cord-010092-uftc8inx 10746 9 3 3 CD cord-010092-uftc8inx 10746 10 exons exon NNS cord-010092-uftc8inx 10746 11 , , , cord-010092-uftc8inx 10746 12 predicting predict VBG cord-010092-uftc8inx 10746 13 RhD rhd NN cord-010092-uftc8inx 10746 14 - - HYPH cord-010092-uftc8inx 10746 15 positive positive JJ cord-010092-uftc8inx 10746 16 . . . cord-010092-uftc8inx 10747 1 No no DT cord-010092-uftc8inx 10747 2 maternal maternal JJ cord-010092-uftc8inx 10747 3 RHD RHD NNP cord-010092-uftc8inx 10747 4 sequences sequence NNS cord-010092-uftc8inx 10747 5 were be VBD cord-010092-uftc8inx 10747 6 detected detect VBN cord-010092-uftc8inx 10747 7 consistent consistent JJ cord-010092-uftc8inx 10747 8 with with IN cord-010092-uftc8inx 10747 9 homozygosity homozygosity NN cord-010092-uftc8inx 10747 10 for for IN cord-010092-uftc8inx 10747 11 the the DT cord-010092-uftc8inx 10747 12 RHD RHD NNP cord-010092-uftc8inx 10747 13 deleted delete VBN cord-010092-uftc8inx 10747 14 haplotype haplotype NN cord-010092-uftc8inx 10747 15 . . . cord-010092-uftc8inx 10748 1 For for IN cord-010092-uftc8inx 10748 2 both both DT cord-010092-uftc8inx 10748 3 paternal paternal JJ cord-010092-uftc8inx 10748 4 and and CC cord-010092-uftc8inx 10748 5 cord cord NN cord-010092-uftc8inx 10748 6 genomic genomic JJ cord-010092-uftc8inx 10748 7 DNA dna NN cord-010092-uftc8inx 10748 8 ( ( -LRB- cord-010092-uftc8inx 10748 9 gDNA gDNA NNP cord-010092-uftc8inx 10748 10 ) ) -RRB- cord-010092-uftc8inx 10748 11 , , , cord-010092-uftc8inx 10748 12 BeadChip BeadChip NNP cord-010092-uftc8inx 10748 13 genotyping genotyping NN cord-010092-uftc8inx 10748 14 predicted predict VBD cord-010092-uftc8inx 10748 15 a a DT cord-010092-uftc8inx 10748 16 RhD rhd NN cord-010092-uftc8inx 10748 17 variant variant NN cord-010092-uftc8inx 10748 18 " " '' cord-010092-uftc8inx 10748 19 DIIIa DIIIa NNS cord-010092-uftc8inx 10748 20 / / SYM cord-010092-uftc8inx 10748 21 ceHAR ceHAR NNS cord-010092-uftc8inx 10748 22 " " '' cord-010092-uftc8inx 10748 23 . . . cord-010092-uftc8inx 10749 1 Furthermore furthermore RB cord-010092-uftc8inx 10749 2 , , , cord-010092-uftc8inx 10749 3 signal signal NN cord-010092-uftc8inx 10749 4 drop drop NN cord-010092-uftc8inx 10749 5 out out RP cord-010092-uftc8inx 10749 6 was be VBD cord-010092-uftc8inx 10749 7 observed observe VBN cord-010092-uftc8inx 10749 8 at at IN cord-010092-uftc8inx 10749 9 3 3 CD cord-010092-uftc8inx 10749 10 nucleotide nucleotide JJ cord-010092-uftc8inx 10749 11 positions position NNS cord-010092-uftc8inx 10749 12 ( ( -LRB- cord-010092-uftc8inx 10749 13 c.1154 c.1154 NNP cord-010092-uftc8inx 10749 14 , , , cord-010092-uftc8inx 10749 15 c.1193 c.1193 NNP cord-010092-uftc8inx 10749 16 , , , cord-010092-uftc8inx 10749 17 c.1227 c.1227 NN cord-010092-uftc8inx 10749 18 ) ) -RRB- cord-010092-uftc8inx 10749 19 located locate VBN cord-010092-uftc8inx 10749 20 in in IN cord-010092-uftc8inx 10749 21 RHD RHD NNP cord-010092-uftc8inx 10749 22 Exon Exon NNP cord-010092-uftc8inx 10749 23 9 9 CD cord-010092-uftc8inx 10749 24 suggesting suggest VBG cord-010092-uftc8inx 10749 25 Exon Exon NNP cord-010092-uftc8inx 10749 26 9 9 CD cord-010092-uftc8inx 10749 27 was be VBD cord-010092-uftc8inx 10749 28 either either CC cord-010092-uftc8inx 10749 29 deleted delete VBN cord-010092-uftc8inx 10749 30 or or CC cord-010092-uftc8inx 10749 31 RHCE RHCE NNP cord-010092-uftc8inx 10749 32 - - HYPH cord-010092-uftc8inx 10749 33 replaced replace VBN cord-010092-uftc8inx 10749 34 . . . cord-010092-uftc8inx 10750 1 Paternal paternal JJ cord-010092-uftc8inx 10750 2 and and CC cord-010092-uftc8inx 10750 3 cord cord NN cord-010092-uftc8inx 10750 4 gDNA gdna NN cord-010092-uftc8inx 10750 5 sequencing sequencing NN cord-010092-uftc8inx 10750 6 detected detect VBD cord-010092-uftc8inx 10750 7 4 4 CD cord-010092-uftc8inx 10750 8 out out IN cord-010092-uftc8inx 10750 9 of of IN cord-010092-uftc8inx 10750 10 6 6 CD cord-010092-uftc8inx 10750 11 SNPs snp NNS cord-010092-uftc8inx 10750 12 ( ( -LRB- cord-010092-uftc8inx 10751 1 c.186G c.186G NNP cord-010092-uftc8inx 10751 2 > > XX cord-010092-uftc8inx 10751 3 T T NNP cord-010092-uftc8inx 10751 4 , , , cord-010092-uftc8inx 10751 5 c.410C c.410C NNP cord-010092-uftc8inx 10752 1 > > XX cord-010092-uftc8inx 10753 1 T T NNP cord-010092-uftc8inx 10753 2 , , , cord-010092-uftc8inx 10753 3 c.455A c.455A NNP cord-010092-uftc8inx 10753 4 > > XX cord-010092-uftc8inx 10753 5 C C NNP cord-010092-uftc8inx 10753 6 , , , cord-010092-uftc8inx 10753 7 c.602C c.602C NNP cord-010092-uftc8inx 10753 8 > > XX cord-010092-uftc8inx 10753 9 G g NN cord-010092-uftc8inx 10753 10 ) ) -RRB- cord-010092-uftc8inx 10753 11 associated associate VBN cord-010092-uftc8inx 10753 12 with with IN cord-010092-uftc8inx 10753 13 DIIIa DIIIa NNS cord-010092-uftc8inx 10753 14 phenotype phenotype NN cord-010092-uftc8inx 10753 15 plus plus CC cord-010092-uftc8inx 10753 16 2 2 CD cord-010092-uftc8inx 10753 17 additional additional JJ cord-010092-uftc8inx 10753 18 SNPs snp NNS cord-010092-uftc8inx 10753 19 ( ( -LRB- cord-010092-uftc8inx 10753 20 c.604 c.604 NN cord-010092-uftc8inx 10753 21 G g NN cord-010092-uftc8inx 10753 22 > > XX cord-010092-uftc8inx 10754 1 A a DT cord-010092-uftc8inx 10754 2 , , , cord-010092-uftc8inx 10754 3 c.733G c.733G NNP cord-010092-uftc8inx 10754 4 > > XX cord-010092-uftc8inx 10754 5 C C NNP cord-010092-uftc8inx 10754 6 ) ) -RRB- cord-010092-uftc8inx 10754 7 on on IN cord-010092-uftc8inx 10754 8 the the DT cord-010092-uftc8inx 10754 9 RHD RHD NNP cord-010092-uftc8inx 10754 10 gene gene NN cord-010092-uftc8inx 10754 11 . . . cord-010092-uftc8inx 10755 1 Both both DT cord-010092-uftc8inx 10755 2 were be VBD cord-010092-uftc8inx 10755 3 RHD RHD NNP cord-010092-uftc8inx 10755 4 hemizygote hemizygote NN cord-010092-uftc8inx 10755 5 by by IN cord-010092-uftc8inx 10755 6 CNV CNV NNP cord-010092-uftc8inx 10755 7 analysis analysis NN cord-010092-uftc8inx 10755 8 . . . cord-010092-uftc8inx 10756 1 No no DT cord-010092-uftc8inx 10756 2 RHCE RHCE NNP cord-010092-uftc8inx 10756 3 variants variant NNS cord-010092-uftc8inx 10756 4 were be VBD cord-010092-uftc8inx 10756 5 detected detect VBN cord-010092-uftc8inx 10756 6 . . . cord-010092-uftc8inx 10757 1 Clinical clinical JJ cord-010092-uftc8inx 10757 2 case case NN cord-010092-uftc8inx 10757 3 features feature VBZ cord-010092-uftc8inx 10757 4 : : : cord-010092-uftc8inx 10758 1 The the DT cord-010092-uftc8inx 10758 2 maternal maternal JJ cord-010092-uftc8inx 10758 3 anti anti JJ cord-010092-uftc8inx 10758 4 - - JJ cord-010092-uftc8inx 10758 5 D d JJ cord-010092-uftc8inx 10758 6 quantitation quantitation NN cord-010092-uftc8inx 10758 7 increased increase VBD cord-010092-uftc8inx 10758 8 from from IN cord-010092-uftc8inx 10758 9 5.3 5.3 CD cord-010092-uftc8inx 10758 10 IU IU NNP cord-010092-uftc8inx 10758 11 / / , cord-010092-uftc8inx 10758 12 ml ml NN cord-010092-uftc8inx 10758 13 ( ( -LRB- cord-010092-uftc8inx 10758 14 16 16 CD cord-010092-uftc8inx 10758 15 weeks week NNS cord-010092-uftc8inx 10758 16 gestation gestation NN cord-010092-uftc8inx 10758 17 ) ) -RRB- cord-010092-uftc8inx 10758 18 to to IN cord-010092-uftc8inx 10758 19 166 166 CD cord-010092-uftc8inx 10758 20 IU IU NNP cord-010092-uftc8inx 10758 21 / / , cord-010092-uftc8inx 10758 22 ml ml NN cord-010092-uftc8inx 10758 23 ( ( -LRB- cord-010092-uftc8inx 10758 24 33 33 CD cord-010092-uftc8inx 10758 25 weeks week NNS cord-010092-uftc8inx 10758 26 gestation gestation NN cord-010092-uftc8inx 10758 27 ) ) -RRB- cord-010092-uftc8inx 10758 28 . . . cord-010092-uftc8inx 10759 1 The the DT cord-010092-uftc8inx 10759 2 fetus fetus NN cord-010092-uftc8inx 10759 3 required require VBD cord-010092-uftc8inx 10759 4 3 3 CD cord-010092-uftc8inx 10759 5 intrauterine intrauterine JJ cord-010092-uftc8inx 10759 6 transfusions transfusion NNS cord-010092-uftc8inx 10759 7 during during IN cord-010092-uftc8inx 10759 8 the the DT cord-010092-uftc8inx 10759 9 pregnancy pregnancy NN cord-010092-uftc8inx 10759 10 to to TO cord-010092-uftc8inx 10759 11 manage manage VB cord-010092-uftc8inx 10759 12 the the DT cord-010092-uftc8inx 10759 13 HDFN HDFN NNP cord-010092-uftc8inx 10759 14 . . . cord-010092-uftc8inx 10760 1 Summary Summary NNP cord-010092-uftc8inx 10760 2 / / SYM cord-010092-uftc8inx 10760 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 10760 4 : : : cord-010092-uftc8inx 10761 1 Both both DT cord-010092-uftc8inx 10761 2 father father NN cord-010092-uftc8inx 10761 3 and and CC cord-010092-uftc8inx 10761 4 fetus fetus NN cord-010092-uftc8inx 10761 5 carry carry VBP cord-010092-uftc8inx 10761 6 an an DT cord-010092-uftc8inx 10761 7 RHD RHD NNP cord-010092-uftc8inx 10761 8 allele allele NN cord-010092-uftc8inx 10761 9 that that WDT cord-010092-uftc8inx 10761 10 does do VBZ cord-010092-uftc8inx 10761 11 not not RB cord-010092-uftc8inx 10761 12 align align VB cord-010092-uftc8inx 10761 13 with with IN cord-010092-uftc8inx 10761 14 alleles allele NNS cord-010092-uftc8inx 10761 15 encoding encode VBG cord-010092-uftc8inx 10761 16 DIII DIII NNP cord-010092-uftc8inx 10761 17 phenotypes phenotype NNS cord-010092-uftc8inx 10761 18 . . . cord-010092-uftc8inx 10762 1 This this DT cord-010092-uftc8inx 10762 2 putative putative JJ cord-010092-uftc8inx 10762 3 novel novel JJ cord-010092-uftc8inx 10762 4 RHD RHD NNP cord-010092-uftc8inx 10762 5 variant variant NN cord-010092-uftc8inx 10762 6 allele allele NN cord-010092-uftc8inx 10762 7 comprises comprise VBZ cord-010092-uftc8inx 10762 8 SNPs SNPs NNPS cord-010092-uftc8inx 10762 9 associated associate VBN cord-010092-uftc8inx 10762 10 with with IN cord-010092-uftc8inx 10762 11 DIIIa DIIIa NNS cord-010092-uftc8inx 10762 12 and and CC cord-010092-uftc8inx 10762 13 with with IN cord-010092-uftc8inx 10762 14 a a DT cord-010092-uftc8inx 10762 15 possible possible JJ cord-010092-uftc8inx 10762 16 Exon Exon NNP cord-010092-uftc8inx 10762 17 9 9 CD cord-010092-uftc8inx 10762 18 deletion deletion NN cord-010092-uftc8inx 10762 19 / / SYM cord-010092-uftc8inx 10762 20 RHCEreplaced rhcereplaced NN cord-010092-uftc8inx 10762 21 . . . cord-010092-uftc8inx 10763 1 A a DT cord-010092-uftc8inx 10763 2 similar similar JJ cord-010092-uftc8inx 10763 3 allele allele NN cord-010092-uftc8inx 10763 4 was be VBD cord-010092-uftc8inx 10763 5 reported report VBN cord-010092-uftc8inx 10763 6 in in IN cord-010092-uftc8inx 10763 7 literature literature NN cord-010092-uftc8inx 10763 8 , , , cord-010092-uftc8inx 10763 9 although although IN cord-010092-uftc8inx 10763 10 based base VBN cord-010092-uftc8inx 10763 11 on on IN cord-010092-uftc8inx 10763 12 sequence sequence NN cord-010092-uftc8inx 10763 13 analysis analysis NN cord-010092-uftc8inx 10763 14 only only RB cord-010092-uftc8inx 10763 15 , , , cord-010092-uftc8inx 10763 16 with with IN cord-010092-uftc8inx 10763 17 no no DT cord-010092-uftc8inx 10763 18 phenotype phenotype NN cord-010092-uftc8inx 10763 19 data datum NNS cord-010092-uftc8inx 10763 20 . . . cord-010092-uftc8inx 10764 1 The the DT cord-010092-uftc8inx 10764 2 variant variant JJ cord-010092-uftc8inx 10764 3 allele allele NN cord-010092-uftc8inx 10764 4 here here RB cord-010092-uftc8inx 10764 5 encodes encode VBZ cord-010092-uftc8inx 10764 6 RhD rhd NN cord-010092-uftc8inx 10764 7 - - HYPH cord-010092-uftc8inx 10764 8 positive positive JJ cord-010092-uftc8inx 10764 9 phenotype phenotype NN cord-010092-uftc8inx 10764 10 and and CC cord-010092-uftc8inx 10764 11 we -PRON- PRP cord-010092-uftc8inx 10764 12 predict predict VBP cord-010092-uftc8inx 10764 13 that that IN cord-010092-uftc8inx 10764 14 there there EX cord-010092-uftc8inx 10764 15 may may MD cord-010092-uftc8inx 10764 16 be be VB cord-010092-uftc8inx 10764 17 a a DT cord-010092-uftc8inx 10764 18 loss loss NN cord-010092-uftc8inx 10764 19 of of IN cord-010092-uftc8inx 10764 20 D d NN cord-010092-uftc8inx 10764 21 - - HYPH cord-010092-uftc8inx 10764 22 epitopes epitope NNS cord-010092-uftc8inx 10764 23 . . . cord-010092-uftc8inx 10765 1 Notwithstanding notwithstanding IN cord-010092-uftc8inx 10765 2 , , , cord-010092-uftc8inx 10765 3 the the DT cord-010092-uftc8inx 10765 4 clinical clinical JJ cord-010092-uftc8inx 10765 5 presentation presentation NN cord-010092-uftc8inx 10765 6 shows show VBZ cord-010092-uftc8inx 10765 7 that that IN cord-010092-uftc8inx 10765 8 maternal maternal JJ cord-010092-uftc8inx 10765 9 anti anti JJ cord-010092-uftc8inx 10765 10 - - JJ cord-010092-uftc8inx 10765 11 D d JJ cord-010092-uftc8inx 10765 12 against against IN cord-010092-uftc8inx 10765 13 this this DT cord-010092-uftc8inx 10765 14 RhD rhd NN cord-010092-uftc8inx 10765 15 phenotype phenotype NN cord-010092-uftc8inx 10765 16 ( ( -LRB- cord-010092-uftc8inx 10765 17 presumed presume VBN cord-010092-uftc8inx 10765 18 partial partial JJ cord-010092-uftc8inx 10765 19 ) ) -RRB- cord-010092-uftc8inx 10765 20 is be VBZ cord-010092-uftc8inx 10765 21 associated associate VBN cord-010092-uftc8inx 10765 22 with with IN cord-010092-uftc8inx 10765 23 a a DT cord-010092-uftc8inx 10765 24 severe severe JJ cord-010092-uftc8inx 10765 25 HDFN HDFN NNP cord-010092-uftc8inx 10765 26 and and CC cord-010092-uftc8inx 10765 27 that that IN cord-010092-uftc8inx 10765 28 such such JJ cord-010092-uftc8inx 10765 29 RhD RhD NNP cord-010092-uftc8inx 10765 30 blood blood NN cord-010092-uftc8inx 10765 31 group group NN cord-010092-uftc8inx 10765 32 phenotypes phenotype NNS cord-010092-uftc8inx 10765 33 are be VBP cord-010092-uftc8inx 10765 34 of of IN cord-010092-uftc8inx 10765 35 clinical clinical JJ cord-010092-uftc8inx 10765 36 significance significance NN cord-010092-uftc8inx 10765 37 for for IN cord-010092-uftc8inx 10765 38 alloimmunised alloimmunise VBN cord-010092-uftc8inx 10765 39 pregnancies pregnancy NNS cord-010092-uftc8inx 10765 40 . . . cord-010092-uftc8inx 10766 1 Abstract Abstract NNP cord-010092-uftc8inx 10766 2 withdrawn withdraw VBN cord-010092-uftc8inx 10766 3 . . . cord-010092-uftc8inx 10767 1 Background background NN cord-010092-uftc8inx 10767 2 : : : cord-010092-uftc8inx 10768 1 CD109 CD109 NNP cord-010092-uftc8inx 10768 2 is be VBZ cord-010092-uftc8inx 10768 3 a a DT cord-010092-uftc8inx 10768 4 glycosylphosphatidylinositol glycosylphosphatidylinositol NN cord-010092-uftc8inx 10768 5 ( ( -LRB- cord-010092-uftc8inx 10768 6 GPI)-anchored gpi)-anchored JJ cord-010092-uftc8inx 10768 7 protein protein NN cord-010092-uftc8inx 10768 8 with with IN cord-010092-uftc8inx 10768 9 apparent apparent JJ cord-010092-uftc8inx 10768 10 molecular molecular JJ cord-010092-uftc8inx 10768 11 mass mass NN cord-010092-uftc8inx 10768 12 of of IN cord-010092-uftc8inx 10768 13 170 170 CD cord-010092-uftc8inx 10768 14 kDa kDa NNS cord-010092-uftc8inx 10768 15 . . . cord-010092-uftc8inx 10769 1 In in IN cord-010092-uftc8inx 10769 2 addition addition NN cord-010092-uftc8inx 10769 3 to to IN cord-010092-uftc8inx 10769 4 being be VBG cord-010092-uftc8inx 10769 5 expressed express VBN cord-010092-uftc8inx 10769 6 on on IN cord-010092-uftc8inx 10769 7 human human JJ cord-010092-uftc8inx 10769 8 PLTs plt NNS cord-010092-uftc8inx 10769 9 , , , cord-010092-uftc8inx 10769 10 CD109 CD109 NNP cord-010092-uftc8inx 10769 11 is be VBZ cord-010092-uftc8inx 10769 12 expressed express VBN cord-010092-uftc8inx 10769 13 on on IN cord-010092-uftc8inx 10769 14 activated activate VBN cord-010092-uftc8inx 10769 15 T t NN cord-010092-uftc8inx 10769 16 - - HYPH cord-010092-uftc8inx 10769 17 cells cell NNS cord-010092-uftc8inx 10769 18 , , , cord-010092-uftc8inx 10769 19 endothelial endothelial JJ cord-010092-uftc8inx 10769 20 cells cell NNS cord-010092-uftc8inx 10769 21 , , , cord-010092-uftc8inx 10769 22 CD34 CD34 NNP cord-010092-uftc8inx 10769 23 + + CC cord-010092-uftc8inx 10769 24 hematopoietic hematopoietic JJ cord-010092-uftc8inx 10769 25 stem stem NN cord-010092-uftc8inx 10769 26 cells cell NNS cord-010092-uftc8inx 10769 27 as as RB cord-010092-uftc8inx 10769 28 well well RB cord-010092-uftc8inx 10769 29 as as IN cord-010092-uftc8inx 10769 30 on on IN cord-010092-uftc8inx 10769 31 progenitor progenitor NN cord-010092-uftc8inx 10769 32 cells cell NNS cord-010092-uftc8inx 10769 33 . . . cord-010092-uftc8inx 10770 1 In in IN cord-010092-uftc8inx 10770 2 the the DT cord-010092-uftc8inx 10770 3 Chinese chinese JJ cord-010092-uftc8inx 10770 4 population population NN cord-010092-uftc8inx 10770 5 , , , cord-010092-uftc8inx 10770 6 the the DT cord-010092-uftc8inx 10770 7 calculated calculate VBN cord-010092-uftc8inx 10770 8 allele allele NN cord-010092-uftc8inx 10770 9 frequencies frequency NNS cord-010092-uftc8inx 10770 10 of of IN cord-010092-uftc8inx 10770 11 HPA-15a HPA-15a NNP cord-010092-uftc8inx 10770 12 and and CC cord-010092-uftc8inx 10770 13 -15b -15b WDT cord-010092-uftc8inx 10770 14 are be VBP cord-010092-uftc8inx 10770 15 0.505 0.505 CD cord-010092-uftc8inx 10770 16 and and CC cord-010092-uftc8inx 10770 17 0.495 0.495 CD cord-010092-uftc8inx 10770 18 , , , cord-010092-uftc8inx 10770 19 respectively respectively RB cord-010092-uftc8inx 10770 20 . . . cord-010092-uftc8inx 10771 1 Based base VBN cord-010092-uftc8inx 10771 2 on on IN cord-010092-uftc8inx 10771 3 these these DT cord-010092-uftc8inx 10771 4 data datum NNS cord-010092-uftc8inx 10771 5 , , , cord-010092-uftc8inx 10771 6 the the DT cord-010092-uftc8inx 10771 7 risk risk NN cord-010092-uftc8inx 10771 8 of of IN cord-010092-uftc8inx 10771 9 alloimmunization alloimmunization NN cord-010092-uftc8inx 10771 10 against against IN cord-010092-uftc8inx 10771 11 HPA-15 HPA-15 NNP cord-010092-uftc8inx 10771 12 alloantibodies alloantibody NNS cord-010092-uftc8inx 10771 13 due due JJ cord-010092-uftc8inx 10771 14 to to IN cord-010092-uftc8inx 10771 15 incompatible incompatible JJ cord-010092-uftc8inx 10771 16 PLT PLT NNP cord-010092-uftc8inx 10771 17 transfusion transfusion NN cord-010092-uftc8inx 10771 18 or or CC cord-010092-uftc8inx 10771 19 pregnancy pregnancy NN cord-010092-uftc8inx 10771 20 is be VBZ cord-010092-uftc8inx 10771 21 expected expect VBN cord-010092-uftc8inx 10771 22 to to TO cord-010092-uftc8inx 10771 23 occur occur VB cord-010092-uftc8inx 10771 24 in in IN cord-010092-uftc8inx 10771 25 relatively relatively RB cord-010092-uftc8inx 10771 26 high high JJ cord-010092-uftc8inx 10771 27 frequency frequency NN cord-010092-uftc8inx 10771 28 . . . cord-010092-uftc8inx 10772 1 However however RB cord-010092-uftc8inx 10772 2 , , , cord-010092-uftc8inx 10772 3 until until IN cord-010092-uftc8inx 10772 4 today today NN cord-010092-uftc8inx 10772 5 there there EX cord-010092-uftc8inx 10772 6 is be VBZ cord-010092-uftc8inx 10772 7 no no DT cord-010092-uftc8inx 10772 8 report report NN cord-010092-uftc8inx 10772 9 of of IN cord-010092-uftc8inx 10772 10 HPA-15 hpa-15 CD cord-010092-uftc8inx 10772 11 alloimmunization alloimmunization NN cord-010092-uftc8inx 10772 12 in in IN cord-010092-uftc8inx 10772 13 the the DT cord-010092-uftc8inx 10772 14 Chinese chinese JJ cord-010092-uftc8inx 10772 15 population population NN cord-010092-uftc8inx 10772 16 . . . cord-010092-uftc8inx 10773 1 In in IN cord-010092-uftc8inx 10773 2 this this DT cord-010092-uftc8inx 10773 3 study study NN cord-010092-uftc8inx 10773 4 , , , cord-010092-uftc8inx 10773 5 we -PRON- PRP cord-010092-uftc8inx 10773 6 analyzed analyze VBD cord-010092-uftc8inx 10773 7 sera sera NNP cord-010092-uftc8inx 10773 8 from from IN cord-010092-uftc8inx 10773 9 hydrop hydrop NNP cord-010092-uftc8inx 10773 10 fetus fetus NN cord-010092-uftc8inx 10773 11 cases case NNS cord-010092-uftc8inx 10773 12 by by IN cord-010092-uftc8inx 10773 13 MAIPA MAIPA NNP cord-010092-uftc8inx 10773 14 technique technique NN cord-010092-uftc8inx 10773 15 and and CC cord-010092-uftc8inx 10773 16 ICFA ICFA NNP cord-010092-uftc8inx 10773 17 . . . cord-010092-uftc8inx 10774 1 Aims aim VBZ cord-010092-uftc8inx 10774 2 : : : cord-010092-uftc8inx 10774 3 To to TO cord-010092-uftc8inx 10774 4 detect detect VB cord-010092-uftc8inx 10774 5 the the DT cord-010092-uftc8inx 10774 6 anti anti JJ cord-010092-uftc8inx 10774 7 - - JJ cord-010092-uftc8inx 10774 8 HPA HPA NNP cord-010092-uftc8inx 10774 9 15b 15b NNS cord-010092-uftc8inx 10774 10 alloantibodies alloantibody NNS cord-010092-uftc8inx 10774 11 by by IN cord-010092-uftc8inx 10774 12 MAIPA MAIPA NNP cord-010092-uftc8inx 10774 13 and and CC cord-010092-uftc8inx 10774 14 ICFA ICFA NNP cord-010092-uftc8inx 10774 15 . . . cord-010092-uftc8inx 10775 1 Methods method NNS cord-010092-uftc8inx 10775 2 : : : cord-010092-uftc8inx 10776 1 A a DT cord-010092-uftc8inx 10776 2 24-year 24-year JJ cord-010092-uftc8inx 10776 3 - - HYPH cord-010092-uftc8inx 10776 4 old old JJ cord-010092-uftc8inx 10776 5 mother mother NN cord-010092-uftc8inx 10776 6 , , , cord-010092-uftc8inx 10776 7 gravida gravida NNP cord-010092-uftc8inx 10776 8 2 2 CD cord-010092-uftc8inx 10776 9 / / SYM cord-010092-uftc8inx 10776 10 para para NNP cord-010092-uftc8inx 10776 11 0 0 CD cord-010092-uftc8inx 10776 12 . . . cord-010092-uftc8inx 10777 1 The the DT cord-010092-uftc8inx 10777 2 mother mother NN cord-010092-uftc8inx 10777 3 in in IN cord-010092-uftc8inx 10777 4 the the DT cord-010092-uftc8inx 10777 5 first first JJ cord-010092-uftc8inx 10777 6 pregnancy pregnancy NN cord-010092-uftc8inx 10777 7 was be VBD cord-010092-uftc8inx 10777 8 diagnosed diagnose VBN cord-010092-uftc8inx 10777 9 hydrop hydrop NN cord-010092-uftc8inx 10777 10 fetus fetus NN cord-010092-uftc8inx 10777 11 at at IN cord-010092-uftc8inx 10777 12 pregnancy pregnancy NN cord-010092-uftc8inx 10777 13 33 33 CD cord-010092-uftc8inx 10777 14 weeks week NNS cord-010092-uftc8inx 10777 15 by by IN cord-010092-uftc8inx 10777 16 ultrasound ultrasound NN cord-010092-uftc8inx 10777 17 . . . cord-010092-uftc8inx 10778 1 In in IN cord-010092-uftc8inx 10778 2 the the DT cord-010092-uftc8inx 10778 3 second second JJ cord-010092-uftc8inx 10778 4 pregnancy pregnancy NN cord-010092-uftc8inx 10778 5 , , , cord-010092-uftc8inx 10778 6 fetal fetal JJ cord-010092-uftc8inx 10778 7 hydrops hydrop NNS cord-010092-uftc8inx 10778 8 was be VBD cord-010092-uftc8inx 10778 9 observed observe VBN cord-010092-uftc8inx 10778 10 by by IN cord-010092-uftc8inx 10778 11 ultrasound ultrasound NN cord-010092-uftc8inx 10778 12 at at IN cord-010092-uftc8inx 10778 13 pregnancy pregnancy NN cord-010092-uftc8inx 10778 14 24 24 CD cord-010092-uftc8inx 10778 15 weeks week NNS cord-010092-uftc8inx 10778 16 . . . cord-010092-uftc8inx 10779 1 The the DT cord-010092-uftc8inx 10779 2 mother mother NN cord-010092-uftc8inx 10779 3 's 's POS cord-010092-uftc8inx 10779 4 irregular irregular JJ cord-010092-uftc8inx 10779 5 antibody antibody NN cord-010092-uftc8inx 10779 6 test test NN cord-010092-uftc8inx 10779 7 was be VBD cord-010092-uftc8inx 10779 8 negative negative JJ cord-010092-uftc8inx 10779 9 . . . cord-010092-uftc8inx 10780 1 The the DT cord-010092-uftc8inx 10780 2 Maternal maternal JJ cord-010092-uftc8inx 10780 3 platelet platelet NN cord-010092-uftc8inx 10780 4 specific specific JJ cord-010092-uftc8inx 10780 5 antibodies antibody NNS cord-010092-uftc8inx 10780 6 and and CC cord-010092-uftc8inx 10780 7 HLA HLA NNP cord-010092-uftc8inx 10780 8 antibodies antibody NNS cord-010092-uftc8inx 10780 9 were be VBD cord-010092-uftc8inx 10780 10 negative negative JJ cord-010092-uftc8inx 10780 11 . . . cord-010092-uftc8inx 10781 1 Blood blood NN cord-010092-uftc8inx 10781 2 routine routine JJ cord-010092-uftc8inx 10781 3 and and CC cord-010092-uftc8inx 10781 4 morphological morphological JJ cord-010092-uftc8inx 10781 5 examination examination NN cord-010092-uftc8inx 10781 6 of of IN cord-010092-uftc8inx 10781 7 fetal fetal JJ cord-010092-uftc8inx 10781 8 umbilical umbilical JJ cord-010092-uftc8inx 10781 9 cord cord NN cord-010092-uftc8inx 10781 10 blood blood NN cord-010092-uftc8inx 10781 11 showed show VBD cord-010092-uftc8inx 10781 12 that that IN cord-010092-uftc8inx 10781 13 PLT PLT NNP cord-010092-uftc8inx 10781 14 count count NN cord-010092-uftc8inx 10781 15 dropped drop VBD cord-010092-uftc8inx 10781 16 to to IN cord-010092-uftc8inx 10781 17 4.7 4.7 CD cord-010092-uftc8inx 10781 18 9 9 CD cord-010092-uftc8inx 10781 19 10 10 CD cord-010092-uftc8inx 10781 20 10 10 CD cord-010092-uftc8inx 10781 21 /L /l CD cord-010092-uftc8inx 10781 22 , , , cord-010092-uftc8inx 10781 23 WBC WBC NNP cord-010092-uftc8inx 10781 24 count count NN cord-010092-uftc8inx 10781 25 dropped drop VBD cord-010092-uftc8inx 10781 26 to to IN cord-010092-uftc8inx 10781 27 2.96 2.96 CD cord-010092-uftc8inx 10781 28 9 9 CD cord-010092-uftc8inx 10781 29 10 10 CD cord-010092-uftc8inx 10781 30 10 10 CD cord-010092-uftc8inx 10781 31 /L /l CD cord-010092-uftc8inx 10781 32 , , , cord-010092-uftc8inx 10781 33 including include VBG cord-010092-uftc8inx 10781 34 Neutrophil Neutrophil NNP cord-010092-uftc8inx 10781 35 37 37 CD cord-010092-uftc8inx 10781 36 % % NN cord-010092-uftc8inx 10781 37 , , , cord-010092-uftc8inx 10781 38 lymphocyte lymphocyte NN cord-010092-uftc8inx 10781 39 16 16 CD cord-010092-uftc8inx 10781 40 % % NN cord-010092-uftc8inx 10781 41 , , , cord-010092-uftc8inx 10781 42 mononuclear mononuclear JJ cord-010092-uftc8inx 10781 43 43 43 CD cord-010092-uftc8inx 10781 44 % % NN cord-010092-uftc8inx 10781 45 , , , cord-010092-uftc8inx 10781 46 eosinophil eosinophil JJ cord-010092-uftc8inx 10781 47 2 2 CD cord-010092-uftc8inx 10781 48 % % NN cord-010092-uftc8inx 10781 49 , , , cord-010092-uftc8inx 10781 50 basophil basophil NNP cord-010092-uftc8inx 10781 51 2 2 CD cord-010092-uftc8inx 10781 52 % % NN cord-010092-uftc8inx 10782 1 , , , cord-010092-uftc8inx 10782 2 Red red JJ cord-010092-uftc8inx 10782 3 blood blood NN cord-010092-uftc8inx 10782 4 cells cell NNS cord-010092-uftc8inx 10782 5 were be VBD cord-010092-uftc8inx 10782 6 normal normal JJ cord-010092-uftc8inx 10782 7 , , , cord-010092-uftc8inx 10782 8 Hb Hb NNP cord-010092-uftc8inx 10782 9 was be VBD cord-010092-uftc8inx 10782 10 111 111 CD cord-010092-uftc8inx 10782 11 g g NN cord-010092-uftc8inx 10782 12 / / SYM cord-010092-uftc8inx 10782 13 L. L. NNP cord-010092-uftc8inx 10782 14 Screening Screening NNP cord-010092-uftc8inx 10782 15 for for IN cord-010092-uftc8inx 10782 16 HLA HLA NNP cord-010092-uftc8inx 10782 17 and and CC cord-010092-uftc8inx 10783 1 PLT PLT NNP cord-010092-uftc8inx 10783 2 - - HYPH cord-010092-uftc8inx 10783 3 specific specific JJ cord-010092-uftc8inx 10783 4 antibodies antibody NNS cord-010092-uftc8inx 10783 5 was be VBD cord-010092-uftc8inx 10783 6 performed perform VBN cord-010092-uftc8inx 10783 7 using use VBG cord-010092-uftc8inx 10783 8 a a DT cord-010092-uftc8inx 10783 9 ELISA ELISA NNP cord-010092-uftc8inx 10783 10 - - HYPH cord-010092-uftc8inx 10783 11 based base VBN cord-010092-uftc8inx 10783 12 PLT PLT NNP cord-010092-uftc8inx 10783 13 antibody antibody NN cord-010092-uftc8inx 10783 14 kit kit NN cord-010092-uftc8inx 10783 15 ( ( -LRB- cord-010092-uftc8inx 10783 16 PAKPLUS PAKPLUS NNP cord-010092-uftc8inx 10783 17 , , , cord-010092-uftc8inx 10783 18 GTI GTI NNP cord-010092-uftc8inx 10783 19 Diagnostics Diagnostics NNPS cord-010092-uftc8inx 10783 20 ) ) -RRB- cord-010092-uftc8inx 10783 21 as as IN cord-010092-uftc8inx 10783 22 recommended recommend VBN cord-010092-uftc8inx 10783 23 by by IN cord-010092-uftc8inx 10783 24 the the DT cord-010092-uftc8inx 10783 25 manufacturer manufacturer NN cord-010092-uftc8inx 10783 26 . . . cord-010092-uftc8inx 10784 1 PLT PLT NNP cord-010092-uftc8inx 10784 2 antibodies antibody NNS cord-010092-uftc8inx 10784 3 were be VBD cord-010092-uftc8inx 10784 4 detected detect VBN cord-010092-uftc8inx 10784 5 by by IN cord-010092-uftc8inx 10784 6 ICFA ICFA NNP cord-010092-uftc8inx 10784 7 and and CC cord-010092-uftc8inx 10784 8 MAIPA.HPA MAIPA.HPA NNP cord-010092-uftc8inx 10784 9 genotyping genotyping NN cord-010092-uftc8inx 10784 10 was be VBD cord-010092-uftc8inx 10784 11 detected detect VBN cord-010092-uftc8inx 10784 12 by by IN cord-010092-uftc8inx 10784 13 CPR CPR NNP cord-010092-uftc8inx 10784 14 - - HYPH cord-010092-uftc8inx 10784 15 SSP SSP NNP cord-010092-uftc8inx 10784 16 . . . cord-010092-uftc8inx 10785 1 Results result NNS cord-010092-uftc8inx 10785 2 : : : cord-010092-uftc8inx 10786 1 The the DT cord-010092-uftc8inx 10786 2 fetus fetus NN cord-010092-uftc8inx 10786 3 's 's POS cord-010092-uftc8inx 10786 4 genotype genotype NN cord-010092-uftc8inx 10786 5 was be VBD cord-010092-uftc8inx 10786 6 HPA-1a HPA-1a NNP cord-010092-uftc8inx 10786 7 / / SYM cord-010092-uftc8inx 10786 8 a a NN cord-010092-uftc8inx 10786 9 , , , cord-010092-uftc8inx 10787 1 -2a -2a : cord-010092-uftc8inx 10787 2 / / SYM cord-010092-uftc8inx 10787 3 a a NN cord-010092-uftc8inx 10787 4 , , , cord-010092-uftc8inx 10788 1 -3a -3a NFP cord-010092-uftc8inx 10788 2 / / SYM cord-010092-uftc8inx 10788 3 a a NN cord-010092-uftc8inx 10788 4 , , , cord-010092-uftc8inx 10788 5 -4a -4a ADD cord-010092-uftc8inx 10788 6 / / SYM cord-010092-uftc8inx 10788 7 a a NN cord-010092-uftc8inx 10788 8 . . . cord-010092-uftc8inx 10789 1 -5a/ -5a/ : cord-010092-uftc8inx 10790 1 a a LS cord-010092-uftc8inx 10790 2 , , , cord-010092-uftc8inx 10790 3 6a 6a NNP cord-010092-uftc8inx 10790 4 / / SYM cord-010092-uftc8inx 10790 5 a a NN cord-010092-uftc8inx 10790 6 , , , cord-010092-uftc8inx 10790 7 7a 7a NN cord-010092-uftc8inx 10790 8 / / SYM cord-010092-uftc8inx 10790 9 a a NN cord-010092-uftc8inx 10790 10 , , , cord-010092-uftc8inx 10790 11 15a 15a NNP cord-010092-uftc8inx 10790 12 / / SYM cord-010092-uftc8inx 10790 13 b b NN cord-010092-uftc8inx 10790 14 , , , cord-010092-uftc8inx 10791 1 Naka Naka NNP cord-010092-uftc8inx 10791 2 ( ( -LRB- cord-010092-uftc8inx 10791 3 + + CC cord-010092-uftc8inx 10791 4 ) ) -RRB- cord-010092-uftc8inx 10791 5 and and CC cord-010092-uftc8inx 10791 6 the the DT cord-010092-uftc8inx 10791 7 maternal maternal JJ cord-010092-uftc8inx 10791 8 was be VBD cord-010092-uftc8inx 10791 9 HPA-1a HPA-1a NNP cord-010092-uftc8inx 10791 10 / / SYM cord-010092-uftc8inx 10791 11 a a DT cord-010092-uftc8inx 10792 1 , , , cord-010092-uftc8inx 10792 2 -2a -2a : cord-010092-uftc8inx 10792 3 / / SYM cord-010092-uftc8inx 10792 4 b b NN cord-010092-uftc8inx 10792 5 , , , cord-010092-uftc8inx 10792 6 -3a -3a NNP cord-010092-uftc8inx 10792 7 / / SYM cord-010092-uftc8inx 10792 8 a a NN cord-010092-uftc8inx 10792 9 , , , cord-010092-uftc8inx 10792 10 -4a -4a ADD cord-010092-uftc8inx 10792 11 / / SYM cord-010092-uftc8inx 10792 12 a a NN cord-010092-uftc8inx 10792 13 . . . cord-010092-uftc8inx 10793 1 -5a/ -5a/ : cord-010092-uftc8inx 10794 1 a a LS cord-010092-uftc8inx 10794 2 , , , cord-010092-uftc8inx 10794 3 6a 6a NNP cord-010092-uftc8inx 10794 4 / / SYM cord-010092-uftc8inx 10794 5 a a NN cord-010092-uftc8inx 10795 1 , , , cord-010092-uftc8inx 10795 2 7a/ 7a/ CD cord-010092-uftc8inx 10795 3 a a NN cord-010092-uftc8inx 10795 4 , , , cord-010092-uftc8inx 10795 5 15a 15a NNP cord-010092-uftc8inx 10795 6 / / SYM cord-010092-uftc8inx 10795 7 a a NN cord-010092-uftc8inx 10795 8 , , , cord-010092-uftc8inx 10795 9 Naka Naka NNP cord-010092-uftc8inx 10795 10 ( ( -LRB- cord-010092-uftc8inx 10795 11 + + NN cord-010092-uftc8inx 10795 12 ) ) -RRB- cord-010092-uftc8inx 10795 13 . . . cord-010092-uftc8inx 10796 1 The the DT cord-010092-uftc8inx 10796 2 paternal paternal JJ cord-010092-uftc8inx 10796 3 genotype genotype NN cord-010092-uftc8inx 10796 4 was be VBD cord-010092-uftc8inx 10796 5 HPA-1a HPA-1a NNP cord-010092-uftc8inx 10796 6 / / SYM cord-010092-uftc8inx 10796 7 a a NNP cord-010092-uftc8inx 10796 8 , , , cord-010092-uftc8inx 10796 9 2a 2a CD cord-010092-uftc8inx 10796 10 / / SYM cord-010092-uftc8inx 10796 11 b b NN cord-010092-uftc8inx 10796 12 , , , cord-010092-uftc8inx 10796 13 3a 3a NNP cord-010092-uftc8inx 10796 14 / / SYM cord-010092-uftc8inx 10796 15 a a NNP cord-010092-uftc8inx 10796 16 , , , cord-010092-uftc8inx 10796 17 4a 4a CD cord-010092-uftc8inx 10796 18 / / SYM cord-010092-uftc8inx 10796 19 a a NN cord-010092-uftc8inx 10796 20 , , , cord-010092-uftc8inx 10796 21 5a 5a CD cord-010092-uftc8inx 10796 22 / / SYM cord-010092-uftc8inx 10796 23 a a NN cord-010092-uftc8inx 10796 24 , , , cord-010092-uftc8inx 10796 25 6a 6a CD cord-010092-uftc8inx 10796 26 / / SYM cord-010092-uftc8inx 10796 27 a a NN cord-010092-uftc8inx 10796 28 , , , cord-010092-uftc8inx 10796 29 7a 7a NN cord-010092-uftc8inx 10796 30 / / SYM cord-010092-uftc8inx 10796 31 a a NN cord-010092-uftc8inx 10796 32 , , , cord-010092-uftc8inx 10796 33 15a 15a NNP cord-010092-uftc8inx 10796 34 / / SYM cord-010092-uftc8inx 10796 35 b b NN cord-010092-uftc8inx 10796 36 , , , cord-010092-uftc8inx 10797 1 Naka Naka NNP cord-010092-uftc8inx 10797 2 ( ( -LRB- cord-010092-uftc8inx 10797 3 + + NNS cord-010092-uftc8inx 10797 4 ) ) -RRB- cord-010092-uftc8inx 10797 5 , , , cord-010092-uftc8inx 10797 6 which which WDT cord-010092-uftc8inx 10797 7 was be VBD cord-010092-uftc8inx 10797 8 the the DT cord-010092-uftc8inx 10797 9 only only JJ cord-010092-uftc8inx 10797 10 incompatible incompatible JJ cord-010092-uftc8inx 10797 11 antigen antigen NN cord-010092-uftc8inx 10797 12 compared compare VBN cord-010092-uftc8inx 10797 13 with with IN cord-010092-uftc8inx 10797 14 the the DT cord-010092-uftc8inx 10797 15 maternal maternal JJ cord-010092-uftc8inx 10797 16 HPA hpa NN cord-010092-uftc8inx 10797 17 . . . cord-010092-uftc8inx 10798 1 Samples sample NNS cord-010092-uftc8inx 10798 2 were be VBD cord-010092-uftc8inx 10798 3 tested test VBN cord-010092-uftc8inx 10798 4 using use VBG cord-010092-uftc8inx 10798 5 the the DT cord-010092-uftc8inx 10798 6 fresh fresh JJ cord-010092-uftc8inx 10798 7 PLT PLT NNP cord-010092-uftc8inx 10798 8 panels panel NNS cord-010092-uftc8inx 10798 9 consisting consist VBG cord-010092-uftc8inx 10798 10 of of IN cord-010092-uftc8inx 10798 11 HPA-15aa hpa-15aa CD cord-010092-uftc8inx 10799 1 and and CC cord-010092-uftc8inx 10799 2 -15bb -15bb . cord-010092-uftc8inx 10799 3 homozygous homozygous JJ cord-010092-uftc8inx 10799 4 donors donor NNS cord-010092-uftc8inx 10799 5 . . . cord-010092-uftc8inx 10800 1 The the DT cord-010092-uftc8inx 10800 2 reactivity reactivity NN cord-010092-uftc8inx 10800 3 of of IN cord-010092-uftc8inx 10800 4 the the DT cord-010092-uftc8inx 10800 5 negative negative JJ cord-010092-uftc8inx 10800 6 control control NN cord-010092-uftc8inx 10800 7 and and CC cord-010092-uftc8inx 10800 8 the the DT cord-010092-uftc8inx 10800 9 mother mother NN cord-010092-uftc8inx 10800 10 's 's POS cord-010092-uftc8inx 10800 11 sera sera NNP cord-010092-uftc8inx 10800 12 with with IN cord-010092-uftc8inx 10800 13 the the DT cord-010092-uftc8inx 10800 14 PLTs plt NNS cord-010092-uftc8inx 10800 15 from from IN cord-010092-uftc8inx 10800 16 HPA-15a/ HPA-15a/ NNP cord-010092-uftc8inx 10801 1 a a LS cord-010092-uftc8inx 10802 1 ( ( -LRB- cord-010092-uftc8inx 10802 2 Donors donor NNS cord-010092-uftc8inx 10802 3 1 1 CD cord-010092-uftc8inx 10802 4 ) ) -RRB- cord-010092-uftc8inx 10802 5 , , , cord-010092-uftc8inx 10802 6 HPA-15a HPA-15a NNP cord-010092-uftc8inx 10802 7 / / SYM cord-010092-uftc8inx 10802 8 b b NNP cord-010092-uftc8inx 10802 9 ( ( -LRB- cord-010092-uftc8inx 10802 10 Donors donor NNS cord-010092-uftc8inx 10802 11 2 2 CD cord-010092-uftc8inx 10802 12 ) ) -RRB- cord-010092-uftc8inx 10802 13 and and CC cord-010092-uftc8inx 10802 14 HPA-15b HPA-15b NNP cord-010092-uftc8inx 10802 15 / / SYM cord-010092-uftc8inx 10802 16 b b NN cord-010092-uftc8inx 10803 1 ( ( -LRB- cord-010092-uftc8inx 10803 2 Donors donor NNS cord-010092-uftc8inx 10803 3 3 3 CD cord-010092-uftc8inx 10803 4 ) ) -RRB- cord-010092-uftc8inx 10803 5 donors donor NNS cord-010092-uftc8inx 10803 6 by by IN cord-010092-uftc8inx 10803 7 MAIPA MAIPA NNP cord-010092-uftc8inx 10803 8 . . . cord-010092-uftc8inx 10804 1 The the DT cord-010092-uftc8inx 10804 2 mother mother NN cord-010092-uftc8inx 10804 3 's 's POS cord-010092-uftc8inx 10804 4 serum serum NN cord-010092-uftc8inx 10804 5 showed show VBD cord-010092-uftc8inx 10804 6 no no DT cord-010092-uftc8inx 10804 7 reactivity reactivity NN cord-010092-uftc8inx 10804 8 against against IN cord-010092-uftc8inx 10804 9 15a 15a NNS cord-010092-uftc8inx 10804 10 / / SYM cord-010092-uftc8inx 10804 11 a a DT cord-010092-uftc8inx 10804 12 PLTs plt NNS cord-010092-uftc8inx 10804 13 , , , cord-010092-uftc8inx 10804 14 weak weak JJ cord-010092-uftc8inx 10804 15 positive positive JJ cord-010092-uftc8inx 10804 16 reactivity reactivity NN cord-010092-uftc8inx 10804 17 against against IN cord-010092-uftc8inx 10804 18 15a 15a NNS cord-010092-uftc8inx 10804 19 / / SYM cord-010092-uftc8inx 10804 20 b b NN cord-010092-uftc8inx 10804 21 PLTs PLTs NNP cord-010092-uftc8inx 10804 22 ( ( -LRB- cord-010092-uftc8inx 10804 23 OD OD NNP cord-010092-uftc8inx 10804 24 values value VBZ cord-010092-uftc8inx 10804 25 0.28 0.28 CD cord-010092-uftc8inx 10804 26 ) ) -RRB- cord-010092-uftc8inx 10804 27 , , , cord-010092-uftc8inx 10804 28 but but CC cord-010092-uftc8inx 10804 29 strong strong JJ cord-010092-uftc8inx 10804 30 reactivity reactivity NN cord-010092-uftc8inx 10804 31 against against IN cord-010092-uftc8inx 10804 32 15b 15b NNS cord-010092-uftc8inx 10804 33 / / SYM cord-010092-uftc8inx 10804 34 b b NN cord-010092-uftc8inx 10804 35 PLTs PLTs NNP cord-010092-uftc8inx 10805 1 ( ( -LRB- cord-010092-uftc8inx 10805 2 OD OD NNP cord-010092-uftc8inx 10805 3 values value VBZ cord-010092-uftc8inx 10805 4 0.38).This 0.38).this CD cord-010092-uftc8inx 10805 5 finding finding NN cord-010092-uftc8inx 10805 6 could could MD cord-010092-uftc8inx 10805 7 be be VB cord-010092-uftc8inx 10805 8 confirmed confirm VBN cord-010092-uftc8inx 10805 9 by by IN cord-010092-uftc8inx 10805 10 one one CD cord-010092-uftc8inx 10805 11 of of IN cord-010092-uftc8inx 10805 12 the the DT cord-010092-uftc8inx 10805 13 reference reference NN cord-010092-uftc8inx 10805 14 PLT PLT NNP cord-010092-uftc8inx 10805 15 laboratories laboratory NNS cord-010092-uftc8inx 10805 16 ( ( -LRB- cord-010092-uftc8inx 10805 17 Japanese Japanese NNP cord-010092-uftc8inx 10805 18 Red Red NNP cord-010092-uftc8inx 10805 19 Cross Cross NNP cord-010092-uftc8inx 10805 20 Kanto Kanto NNP cord-010092-uftc8inx 10805 21 - - HYPH cord-010092-uftc8inx 10805 22 Koshinetsu Koshinetsu NNP cord-010092-uftc8inx 10805 23 Block Block NNP cord-010092-uftc8inx 10805 24 Blood Blood NNP cord-010092-uftc8inx 10805 25 Center Center NNP cord-010092-uftc8inx 10805 26 , , , cord-010092-uftc8inx 10805 27 Japan Japan NNP cord-010092-uftc8inx 10805 28 ) ) -RRB- cord-010092-uftc8inx 10805 29 using use VBG cord-010092-uftc8inx 10805 30 freshly freshly RB cord-010092-uftc8inx 10805 31 isolated isolate VBN cord-010092-uftc8inx 10805 32 PLTs plt NNS cord-010092-uftc8inx 10805 33 from from IN cord-010092-uftc8inx 10805 34 HPA-15genotyped HPA-15genotyped NNP cord-010092-uftc8inx 10805 35 donors donor NNS cord-010092-uftc8inx 10805 36 ( ( -LRB- cord-010092-uftc8inx 10805 37 Anti Anti NNP cord-010092-uftc8inx 10805 38 - - JJ cord-010092-uftc8inx 10805 39 HPA-15b hpa-15b JJ cord-010092-uftc8inx 10805 40 average average JJ cord-010092-uftc8inx 10805 41 value value NN cord-010092-uftc8inx 10805 42 9.8 9.8 CD cord-010092-uftc8inx 10805 43 ) ) -RRB- cord-010092-uftc8inx 10805 44 . . . cord-010092-uftc8inx 10806 1 Summary Summary NNP cord-010092-uftc8inx 10806 2 / / SYM cord-010092-uftc8inx 10806 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 10806 4 : : : cord-010092-uftc8inx 10807 1 In in IN cord-010092-uftc8inx 10807 2 this this DT cord-010092-uftc8inx 10807 3 study study NN cord-010092-uftc8inx 10807 4 , , , cord-010092-uftc8inx 10807 5 we -PRON- PRP cord-010092-uftc8inx 10807 6 found find VBD cord-010092-uftc8inx 10807 7 anti anti JJ cord-010092-uftc8inx 10807 8 - - JJ cord-010092-uftc8inx 10807 9 HPA-15b hpa-15b JJ cord-010092-uftc8inx 10807 10 in in IN cord-010092-uftc8inx 10807 11 a a DT cord-010092-uftc8inx 10807 12 case case NN cord-010092-uftc8inx 10807 13 of of IN cord-010092-uftc8inx 10807 14 FNAIT FNAIT NNP cord-010092-uftc8inx 10807 15 ( ( -LRB- cord-010092-uftc8inx 10807 16 patient patient JJ cord-010092-uftc8inx 10807 17 HPA-15aa hpa-15aa CD cord-010092-uftc8inx 10807 18 , , , cord-010092-uftc8inx 10807 19 blood blood NN cord-010092-uftc8inx 10807 20 group group NN cord-010092-uftc8inx 10807 21 O O NNP cord-010092-uftc8inx 10807 22 ) ) -RRB- cord-010092-uftc8inx 10807 23 using use VBG cord-010092-uftc8inx 10807 24 the the DT cord-010092-uftc8inx 10807 25 MAIPA MAIPA NNP cord-010092-uftc8inx 10807 26 technique technique NN cord-010092-uftc8inx 10807 27 . . . cord-010092-uftc8inx 10808 1 We -PRON- PRP cord-010092-uftc8inx 10808 2 were be VBD cord-010092-uftc8inx 10808 3 able able JJ cord-010092-uftc8inx 10808 4 to to TO cord-010092-uftc8inx 10808 5 detect detect VB cord-010092-uftc8inx 10808 6 the the DT cord-010092-uftc8inx 10808 7 presence presence NN cord-010092-uftc8inx 10808 8 of of IN cord-010092-uftc8inx 10808 9 HPA-15b HPA-15b NNP cord-010092-uftc8inx 10808 10 alloantibody alloantibody NN cord-010092-uftc8inx 10808 11 in in IN cord-010092-uftc8inx 10808 12 one one CD cord-010092-uftc8inx 10808 13 case case NN cord-010092-uftc8inx 10808 14 of of IN cord-010092-uftc8inx 10808 15 NAIT NAIT NNP cord-010092-uftc8inx 10808 16 . . . cord-010092-uftc8inx 10809 1 Background background NN cord-010092-uftc8inx 10809 2 : : : cord-010092-uftc8inx 10810 1 Fetal fetal JJ cord-010092-uftc8inx 10810 2 and and CC cord-010092-uftc8inx 10810 3 neonatal neonatal JJ cord-010092-uftc8inx 10810 4 alloimmune alloimmune JJ cord-010092-uftc8inx 10810 5 thrombocytopenia thrombocytopenia NN cord-010092-uftc8inx 10810 6 ( ( -LRB- cord-010092-uftc8inx 10810 7 FNAIT FNAIT NNP cord-010092-uftc8inx 10810 8 ) ) -RRB- cord-010092-uftc8inx 10810 9 occurs occur VBZ cord-010092-uftc8inx 10810 10 in in IN cord-010092-uftc8inx 10810 11 1:10000 1:10000 `` cord-010092-uftc8inx 10810 12 live live JJ cord-010092-uftc8inx 10810 13 births birth NNS cord-010092-uftc8inx 10810 14 in in IN cord-010092-uftc8inx 10810 15 Caucasians Caucasians NNPS cord-010092-uftc8inx 10810 16 . . . cord-010092-uftc8inx 10811 1 Serological serological JJ cord-010092-uftc8inx 10811 2 and and CC cord-010092-uftc8inx 10811 3 molecular molecular JJ cord-010092-uftc8inx 10811 4 Human Human NNP cord-010092-uftc8inx 10811 5 Platelet Platelet NNP cord-010092-uftc8inx 10811 6 Antigens Antigens NNP cord-010092-uftc8inx 10811 7 ( ( -LRB- cord-010092-uftc8inx 10811 8 HPA HPA NNP cord-010092-uftc8inx 10811 9 ) ) -RRB- cord-010092-uftc8inx 10811 10 genotyping genotyping NN cord-010092-uftc8inx 10811 11 tests test NNS cord-010092-uftc8inx 10811 12 are be VBP cord-010092-uftc8inx 10811 13 performed perform VBN cord-010092-uftc8inx 10811 14 to to TO cord-010092-uftc8inx 10811 15 investigate investigate VB cord-010092-uftc8inx 10811 16 and and CC cord-010092-uftc8inx 10811 17 conclude conclude VB cord-010092-uftc8inx 10811 18 to to IN cord-010092-uftc8inx 10811 19 FNAIT fnait NN cord-010092-uftc8inx 10811 20 diagnosis diagnosis NN cord-010092-uftc8inx 10811 21 . . . cord-010092-uftc8inx 10812 1 However however RB cord-010092-uftc8inx 10812 2 , , , cord-010092-uftc8inx 10812 3 in in IN cord-010092-uftc8inx 10812 4 few few JJ cord-010092-uftc8inx 10812 5 cases case NNS cord-010092-uftc8inx 10812 6 and and CC cord-010092-uftc8inx 10812 7 particularly particularly RB cord-010092-uftc8inx 10812 8 in in IN cord-010092-uftc8inx 10812 9 case case NN cord-010092-uftc8inx 10812 10 of of IN cord-010092-uftc8inx 10812 11 suspicion suspicion NN cord-010092-uftc8inx 10812 12 of of IN cord-010092-uftc8inx 10812 13 private private JJ cord-010092-uftc8inx 10812 14 platelet platelet NN cord-010092-uftc8inx 10812 15 antigen antigen NN cord-010092-uftc8inx 10812 16 , , , cord-010092-uftc8inx 10812 17 some some DT cord-010092-uftc8inx 10812 18 specialized specialize VBN cord-010092-uftc8inx 10812 19 analyzes analyze NNS cord-010092-uftc8inx 10812 20 must must MD cord-010092-uftc8inx 10812 21 be be VB cord-010092-uftc8inx 10812 22 performed perform VBN cord-010092-uftc8inx 10812 23 in in IN cord-010092-uftc8inx 10812 24 the the DT cord-010092-uftc8inx 10812 25 laboratory laboratory NN cord-010092-uftc8inx 10812 26 ( ( -LRB- cord-010092-uftc8inx 10812 27 lab lab NN cord-010092-uftc8inx 10812 28 ) ) -RRB- cord-010092-uftc8inx 10812 29 . . . cord-010092-uftc8inx 10813 1 These these DT cord-010092-uftc8inx 10813 2 analyzes analyze NNS cord-010092-uftc8inx 10813 3 can can MD cord-010092-uftc8inx 10813 4 range range VB cord-010092-uftc8inx 10813 5 from from IN cord-010092-uftc8inx 10813 6 Sanger Sanger NNP cord-010092-uftc8inx 10813 7 or or CC cord-010092-uftc8inx 10813 8 NGS NGS NNP cord-010092-uftc8inx 10813 9 sequencing sequencing NN cord-010092-uftc8inx 10813 10 to to IN cord-010092-uftc8inx 10813 11 platelet platelet NN cord-010092-uftc8inx 10813 12 serology serology NN cord-010092-uftc8inx 10813 13 with with IN cord-010092-uftc8inx 10813 14 transfected transfecte VBN cord-010092-uftc8inx 10813 15 cells cell NNS cord-010092-uftc8inx 10813 16 . . . cord-010092-uftc8inx 10814 1 Aims aim VBZ cord-010092-uftc8inx 10814 2 : : : cord-010092-uftc8inx 10815 1 The the DT cord-010092-uftc8inx 10815 2 aim aim NN cord-010092-uftc8inx 10815 3 of of IN cord-010092-uftc8inx 10815 4 our -PRON- PRP$ cord-010092-uftc8inx 10815 5 study study NN cord-010092-uftc8inx 10815 6 was be VBD cord-010092-uftc8inx 10815 7 to to TO cord-010092-uftc8inx 10815 8 explore explore VB cord-010092-uftc8inx 10815 9 where where WRB cord-010092-uftc8inx 10815 10 the the DT cord-010092-uftc8inx 10815 11 frontier frontier NN cord-010092-uftc8inx 10815 12 between between IN cord-010092-uftc8inx 10815 13 research research NN cord-010092-uftc8inx 10815 14 and and CC cord-010092-uftc8inx 10815 15 care care NN cord-010092-uftc8inx 10815 16 takes take VBZ cord-010092-uftc8inx 10815 17 place place NN cord-010092-uftc8inx 10815 18 in in IN cord-010092-uftc8inx 10815 19 the the DT cord-010092-uftc8inx 10815 20 field field NN cord-010092-uftc8inx 10815 21 of of IN cord-010092-uftc8inx 10815 22 Platelet Platelet NNP cord-010092-uftc8inx 10815 23 Immunology Immunology NNP cord-010092-uftc8inx 10815 24 through through IN cord-010092-uftc8inx 10815 25 the the DT cord-010092-uftc8inx 10815 26 prism prism NN cord-010092-uftc8inx 10815 27 of of IN cord-010092-uftc8inx 10815 28 the the DT cord-010092-uftc8inx 10815 29 FNAIT FNAIT NNP cord-010092-uftc8inx 10815 30 investigations investigation NNS cord-010092-uftc8inx 10815 31 carried carry VBN cord-010092-uftc8inx 10815 32 out out RP cord-010092-uftc8inx 10815 33 by by IN cord-010092-uftc8inx 10815 34 the the DT cord-010092-uftc8inx 10815 35 Platelet Platelet NNP cord-010092-uftc8inx 10815 36 Immunology Immunology NNP cord-010092-uftc8inx 10815 37 laboratories laboratory NNS cord-010092-uftc8inx 10815 38 . . . cord-010092-uftc8inx 10816 1 Methods method NNS cord-010092-uftc8inx 10816 2 : : : cord-010092-uftc8inx 10817 1 A a DT cord-010092-uftc8inx 10817 2 two two CD cord-010092-uftc8inx 10817 3 - - HYPH cord-010092-uftc8inx 10817 4 part part NN cord-010092-uftc8inx 10817 5 electronic electronic JJ cord-010092-uftc8inx 10817 6 survey survey NN cord-010092-uftc8inx 10817 7 have have VBP cord-010092-uftc8inx 10817 8 been be VBN cord-010092-uftc8inx 10817 9 sent send VBN cord-010092-uftc8inx 10817 10 to to IN cord-010092-uftc8inx 10817 11 foreign foreign JJ cord-010092-uftc8inx 10817 12 platelet platelet NN cord-010092-uftc8inx 10817 13 immunology immunology NN cord-010092-uftc8inx 10817 14 experts expert NNS cord-010092-uftc8inx 10817 15 ( ( -LRB- cord-010092-uftc8inx 10817 16 PIE pie NN cord-010092-uftc8inx 10817 17 ) ) -RRB- cord-010092-uftc8inx 10817 18 from from IN cord-010092-uftc8inx 10817 19 Platelet Platelet NNP cord-010092-uftc8inx 10817 20 Immunobiology Immunobiology NNP cord-010092-uftc8inx 10817 21 Working Working NNP cord-010092-uftc8inx 10817 22 Party Party NNP cord-010092-uftc8inx 10817 23 ( ( -LRB- cord-010092-uftc8inx 10817 24 PIWP PIWP NNP cord-010092-uftc8inx 10817 25 ) ) -RRB- cord-010092-uftc8inx 10817 26 members member NNS cord-010092-uftc8inx 10817 27 and and CC cord-010092-uftc8inx 10817 28 ESPGI ESPGI NNP cord-010092-uftc8inx 10817 29 board board NN cord-010092-uftc8inx 10817 30 members member NNS cord-010092-uftc8inx 10817 31 ( ( -LRB- cord-010092-uftc8inx 10817 32 n n NN cord-010092-uftc8inx 10817 33 = = SYM cord-010092-uftc8inx 10817 34 40 40 CD cord-010092-uftc8inx 10817 35 ) ) -RRB- cord-010092-uftc8inx 10817 36 . . . cord-010092-uftc8inx 10818 1 The the DT cord-010092-uftc8inx 10818 2 first first JJ cord-010092-uftc8inx 10818 3 part part NN cord-010092-uftc8inx 10818 4 focused focus VBD cord-010092-uftc8inx 10818 5 on on IN cord-010092-uftc8inx 10818 6 the the DT cord-010092-uftc8inx 10818 7 lab lab NN cord-010092-uftc8inx 10818 8 practices practice NNS cord-010092-uftc8inx 10818 9 and and CC cord-010092-uftc8inx 10818 10 regulatory regulatory JJ cord-010092-uftc8inx 10818 11 environment environment NN cord-010092-uftc8inx 10818 12 regarding regard VBG cord-010092-uftc8inx 10818 13 to to IN cord-010092-uftc8inx 10818 14 accreditation accreditation NN cord-010092-uftc8inx 10818 15 , , , cord-010092-uftc8inx 10818 16 contact contact NN cord-010092-uftc8inx 10818 17 with with IN cord-010092-uftc8inx 10818 18 patient patient NN cord-010092-uftc8inx 10818 19 , , , cord-010092-uftc8inx 10818 20 informed informed JJ cord-010092-uftc8inx 10818 21 consent consent NN cord-010092-uftc8inx 10818 22 and and CC cord-010092-uftc8inx 10818 23 patient patient NN cord-010092-uftc8inx 10818 24 results result NNS cord-010092-uftc8inx 10818 25 . . . cord-010092-uftc8inx 10819 1 The the DT cord-010092-uftc8inx 10819 2 second second JJ cord-010092-uftc8inx 10819 3 part part NN cord-010092-uftc8inx 10819 4 stressed stress VBD cord-010092-uftc8inx 10819 5 on on IN cord-010092-uftc8inx 10819 6 the the DT cord-010092-uftc8inx 10819 7 investigations investigation NNS cord-010092-uftc8inx 10819 8 performed perform VBN cord-010092-uftc8inx 10819 9 to to TO cord-010092-uftc8inx 10819 10 discover discover VB cord-010092-uftc8inx 10819 11 new new JJ cord-010092-uftc8inx 10819 12 platelet platelet NN cord-010092-uftc8inx 10819 13 antigen antigen NN cord-010092-uftc8inx 10819 14 and and CC cord-010092-uftc8inx 10819 15 more more RBR cord-010092-uftc8inx 10819 16 precisely precisely RB cord-010092-uftc8inx 10819 17 on on IN cord-010092-uftc8inx 10819 18 the the DT cord-010092-uftc8inx 10819 19 perceived perceive VBN cord-010092-uftc8inx 10819 20 status status NN cord-010092-uftc8inx 10819 21 of of IN cord-010092-uftc8inx 10819 22 these these DT cord-010092-uftc8inx 10819 23 analyzes analyze NNS cord-010092-uftc8inx 10819 24 ( ( -LRB- cord-010092-uftc8inx 10819 25 Background background NN cord-010092-uftc8inx 10819 26 : : : cord-010092-uftc8inx 10820 1 Haemolytic haemolytic JJ cord-010092-uftc8inx 10820 2 disease disease NN cord-010092-uftc8inx 10820 3 of of IN cord-010092-uftc8inx 10820 4 the the DT cord-010092-uftc8inx 10820 5 fetus fetus NN cord-010092-uftc8inx 10820 6 and and CC cord-010092-uftc8inx 10820 7 newborn newborn JJ cord-010092-uftc8inx 10820 8 ( ( -LRB- cord-010092-uftc8inx 10820 9 HDFN HDFN NNP cord-010092-uftc8inx 10820 10 ) ) -RRB- cord-010092-uftc8inx 10820 11 can can MD cord-010092-uftc8inx 10820 12 occur occur VB cord-010092-uftc8inx 10820 13 when when WRB cord-010092-uftc8inx 10820 14 maternal maternal JJ cord-010092-uftc8inx 10820 15 red red JJ cord-010092-uftc8inx 10820 16 cell cell NN cord-010092-uftc8inx 10820 17 antibodies antibody NNS cord-010092-uftc8inx 10820 18 , , , cord-010092-uftc8inx 10820 19 directed direct VBN cord-010092-uftc8inx 10820 20 against against IN cord-010092-uftc8inx 10820 21 red red JJ cord-010092-uftc8inx 10820 22 cell cell NN cord-010092-uftc8inx 10820 23 antigens antigen NNS cord-010092-uftc8inx 10820 24 present present JJ cord-010092-uftc8inx 10820 25 on on IN cord-010092-uftc8inx 10820 26 the the DT cord-010092-uftc8inx 10820 27 fetal fetal JJ cord-010092-uftc8inx 10820 28 red red JJ cord-010092-uftc8inx 10820 29 blood blood NN cord-010092-uftc8inx 10820 30 cells cell NNS cord-010092-uftc8inx 10820 31 , , , cord-010092-uftc8inx 10820 32 cross cross VB cord-010092-uftc8inx 10820 33 the the DT cord-010092-uftc8inx 10820 34 placenta placenta NN cord-010092-uftc8inx 10820 35 and and CC cord-010092-uftc8inx 10820 36 enter enter VB cord-010092-uftc8inx 10820 37 the the DT cord-010092-uftc8inx 10820 38 fetal fetal JJ cord-010092-uftc8inx 10820 39 circulation circulation NN cord-010092-uftc8inx 10820 40 . . . cord-010092-uftc8inx 10821 1 In in IN cord-010092-uftc8inx 10821 2 a a DT cord-010092-uftc8inx 10821 3 " " `` cord-010092-uftc8inx 10821 4 traditionally traditionally RB cord-010092-uftc8inx 10821 5 " " '' cord-010092-uftc8inx 10821 6 conceived conceive VBN cord-010092-uftc8inx 10821 7 pregnancy pregnancy NN cord-010092-uftc8inx 10821 8 , , , cord-010092-uftc8inx 10821 9 when when WRB cord-010092-uftc8inx 10821 10 HDFN HDFN NNP cord-010092-uftc8inx 10821 11 occurs occur VBZ cord-010092-uftc8inx 10821 12 , , , cord-010092-uftc8inx 10821 13 it -PRON- PRP cord-010092-uftc8inx 10821 14 is be VBZ cord-010092-uftc8inx 10821 15 as as IN cord-010092-uftc8inx 10821 16 a a DT cord-010092-uftc8inx 10821 17 result result NN cord-010092-uftc8inx 10821 18 of of IN cord-010092-uftc8inx 10821 19 maternal maternal JJ cord-010092-uftc8inx 10821 20 antibodies antibody NNS cord-010092-uftc8inx 10821 21 directed direct VBN cord-010092-uftc8inx 10821 22 against against IN cord-010092-uftc8inx 10821 23 fetal fetal JJ cord-010092-uftc8inx 10821 24 red red JJ cord-010092-uftc8inx 10821 25 cell cell NN cord-010092-uftc8inx 10821 26 antigens antigen NNS cord-010092-uftc8inx 10821 27 in in IN cord-010092-uftc8inx 10821 28 the the DT cord-010092-uftc8inx 10821 29 heterozygous heterozygous JJ cord-010092-uftc8inx 10821 30 state state NN cord-010092-uftc8inx 10821 31 , , , cord-010092-uftc8inx 10821 32 whereby whereby WRB cord-010092-uftc8inx 10821 33 the the DT cord-010092-uftc8inx 10821 34 antigen antigen NN cord-010092-uftc8inx 10821 35 is be VBZ cord-010092-uftc8inx 10821 36 inherited inherit VBN cord-010092-uftc8inx 10821 37 from from IN cord-010092-uftc8inx 10821 38 the the DT cord-010092-uftc8inx 10821 39 father father NN cord-010092-uftc8inx 10821 40 only only RB cord-010092-uftc8inx 10821 41 . . . cord-010092-uftc8inx 10822 1 With with IN cord-010092-uftc8inx 10822 2 the the DT cord-010092-uftc8inx 10822 3 advent advent NN cord-010092-uftc8inx 10822 4 of of IN cord-010092-uftc8inx 10822 5 donor donor NN cord-010092-uftc8inx 10822 6 oocyte oocyte NN cord-010092-uftc8inx 10822 7 ( ( -LRB- cord-010092-uftc8inx 10822 8 DO do VB cord-010092-uftc8inx 10822 9 ) ) -RRB- cord-010092-uftc8inx 10822 10 in in IN cord-010092-uftc8inx 10822 11 - - HYPH cord-010092-uftc8inx 10822 12 vitro vitro FW cord-010092-uftc8inx 10822 13 fertilisation fertilisation NN cord-010092-uftc8inx 10822 14 ( ( -LRB- cord-010092-uftc8inx 10822 15 IVF IVF NNP cord-010092-uftc8inx 10822 16 ) ) -RRB- cord-010092-uftc8inx 10822 17 , , , cord-010092-uftc8inx 10822 18 the the DT cord-010092-uftc8inx 10822 19 addition addition NN cord-010092-uftc8inx 10822 20 of of IN cord-010092-uftc8inx 10822 21 a a DT cord-010092-uftc8inx 10822 22 third third JJ cord-010092-uftc8inx 10822 23 person person NN cord-010092-uftc8inx 10822 24 into into IN cord-010092-uftc8inx 10822 25 the the DT cord-010092-uftc8inx 10822 26 reproductive reproductive JJ cord-010092-uftc8inx 10822 27 equation equation NN cord-010092-uftc8inx 10822 28 allows allow VBZ cord-010092-uftc8inx 10822 29 for for IN cord-010092-uftc8inx 10822 30 the the DT cord-010092-uftc8inx 10822 31 possibility possibility NN cord-010092-uftc8inx 10822 32 of of IN cord-010092-uftc8inx 10822 33 a a DT cord-010092-uftc8inx 10822 34 more more RBR cord-010092-uftc8inx 10822 35 severe severe JJ cord-010092-uftc8inx 10822 36 form form NN cord-010092-uftc8inx 10822 37 of of IN cord-010092-uftc8inx 10822 38 HDFN HDFN NNP cord-010092-uftc8inx 10822 39 when when WRB cord-010092-uftc8inx 10822 40 fetal fetal JJ cord-010092-uftc8inx 10822 41 red red JJ cord-010092-uftc8inx 10822 42 cell cell NN cord-010092-uftc8inx 10822 43 antigens antigen NNS cord-010092-uftc8inx 10822 44 are be VBP cord-010092-uftc8inx 10822 45 present present JJ cord-010092-uftc8inx 10822 46 in in IN cord-010092-uftc8inx 10822 47 the the DT cord-010092-uftc8inx 10822 48 homozygous homozygous JJ cord-010092-uftc8inx 10822 49 state state NN cord-010092-uftc8inx 10822 50 ( ( -LRB- cord-010092-uftc8inx 10822 51 one one CD cord-010092-uftc8inx 10822 52 copy copy NN cord-010092-uftc8inx 10822 53 from from IN cord-010092-uftc8inx 10822 54 father father NN cord-010092-uftc8inx 10822 55 and and CC cord-010092-uftc8inx 10822 56 one one CD cord-010092-uftc8inx 10822 57 copy copy NN cord-010092-uftc8inx 10822 58 from from IN cord-010092-uftc8inx 10822 59 donor donor NN cord-010092-uftc8inx 10822 60 ) ) -RRB- cord-010092-uftc8inx 10822 61 and and CC cord-010092-uftc8inx 10822 62 maternal maternal JJ cord-010092-uftc8inx 10822 63 antibodies antibody NNS cord-010092-uftc8inx 10822 64 are be VBP cord-010092-uftc8inx 10822 65 directed direct VBN cord-010092-uftc8inx 10822 66 against against IN cord-010092-uftc8inx 10822 67 these these DT cord-010092-uftc8inx 10822 68 . . . cord-010092-uftc8inx 10823 1 Antigens antigen NNS cord-010092-uftc8inx 10823 2 expressed express VBN cord-010092-uftc8inx 10823 3 in in IN cord-010092-uftc8inx 10823 4 the the DT cord-010092-uftc8inx 10823 5 homozygous homozygous JJ cord-010092-uftc8inx 10823 6 state state NN cord-010092-uftc8inx 10823 7 will will MD cord-010092-uftc8inx 10823 8 have have VB cord-010092-uftc8inx 10823 9 more more JJR cord-010092-uftc8inx 10823 10 antigens antigen NNS cord-010092-uftc8inx 10823 11 sites site NNS cord-010092-uftc8inx 10823 12 per per IN cord-010092-uftc8inx 10823 13 red red JJ cord-010092-uftc8inx 10823 14 blood blood NN cord-010092-uftc8inx 10823 15 cell cell NN cord-010092-uftc8inx 10823 16 and and CC cord-010092-uftc8inx 10823 17 therefore therefore RB cord-010092-uftc8inx 10823 18 are be VBP cord-010092-uftc8inx 10823 19 at at IN cord-010092-uftc8inx 10823 20 an an DT cord-010092-uftc8inx 10823 21 increased increase VBN cord-010092-uftc8inx 10823 22 risk risk NN cord-010092-uftc8inx 10823 23 of of IN cord-010092-uftc8inx 10823 24 red red JJ cord-010092-uftc8inx 10823 25 cell cell NN cord-010092-uftc8inx 10823 26 destruction destruction NN cord-010092-uftc8inx 10823 27 from from IN cord-010092-uftc8inx 10823 28 the the DT cord-010092-uftc8inx 10823 29 maternal maternal JJ cord-010092-uftc8inx 10823 30 derived derive VBN cord-010092-uftc8inx 10823 31 cognate cognate JJ cord-010092-uftc8inx 10823 32 antibodies antibody NNS cord-010092-uftc8inx 10823 33 . . . cord-010092-uftc8inx 10824 1 Aims aim VBZ cord-010092-uftc8inx 10824 2 : : : cord-010092-uftc8inx 10825 1 To to TO cord-010092-uftc8inx 10825 2 raise raise VB cord-010092-uftc8inx 10825 3 awareness awareness NN cord-010092-uftc8inx 10825 4 of of IN cord-010092-uftc8inx 10825 5 increased increase VBN cord-010092-uftc8inx 10825 6 severity severity NN cord-010092-uftc8inx 10825 7 risk risk NN cord-010092-uftc8inx 10825 8 of of IN cord-010092-uftc8inx 10825 9 HDFN HDFN NNP cord-010092-uftc8inx 10825 10 in in IN cord-010092-uftc8inx 10825 11 donor donor NN cord-010092-uftc8inx 10825 12 oocyte oocyte NN cord-010092-uftc8inx 10825 13 conceived conceive VBD cord-010092-uftc8inx 10825 14 pregnancies pregnancy NNS cord-010092-uftc8inx 10825 15 . . . cord-010092-uftc8inx 10826 1 Methods method NNS cord-010092-uftc8inx 10827 1 : : : cord-010092-uftc8inx 10827 2 We -PRON- PRP cord-010092-uftc8inx 10827 3 describe describe VBP cord-010092-uftc8inx 10827 4 two two CD cord-010092-uftc8inx 10827 5 unusual unusual JJ cord-010092-uftc8inx 10827 6 cases case NNS cord-010092-uftc8inx 10827 7 of of IN cord-010092-uftc8inx 10827 8 HDFN HDFN NNP cord-010092-uftc8inx 10827 9 in in IN cord-010092-uftc8inx 10827 10 our -PRON- PRP$ cord-010092-uftc8inx 10827 11 institution institution NN cord-010092-uftc8inx 10827 12 of of IN cord-010092-uftc8inx 10827 13 two two CD cord-010092-uftc8inx 10827 14 women woman NNS cord-010092-uftc8inx 10827 15 whose whose WP$ cord-010092-uftc8inx 10827 16 pregnancy pregnancy NN cord-010092-uftc8inx 10827 17 was be VBD cord-010092-uftc8inx 10827 18 induced induce VBN cord-010092-uftc8inx 10827 19 using use VBG cord-010092-uftc8inx 10827 20 a a DT cord-010092-uftc8inx 10827 21 donor donor NN cord-010092-uftc8inx 10827 22 oocyte oocyte NN cord-010092-uftc8inx 10827 23 and and CC cord-010092-uftc8inx 10827 24 their -PRON- PRP$ cord-010092-uftc8inx 10827 25 offspring offspring NN cord-010092-uftc8inx 10827 26 requiring require VBG cord-010092-uftc8inx 10827 27 transfusion transfusion NN cord-010092-uftc8inx 10827 28 support support NN cord-010092-uftc8inx 10827 29 in in IN cord-010092-uftc8inx 10827 30 the the DT cord-010092-uftc8inx 10827 31 postnatal postnatal JJ cord-010092-uftc8inx 10827 32 period period NN cord-010092-uftc8inx 10827 33 to to TO cord-010092-uftc8inx 10827 34 treat treat VB cord-010092-uftc8inx 10827 35 HDFN HDFN NNP cord-010092-uftc8inx 10827 36 . . . cord-010092-uftc8inx 10828 1 Results result NNS cord-010092-uftc8inx 10828 2 : : : cord-010092-uftc8inx 10829 1 The the DT cord-010092-uftc8inx 10829 2 first first JJ cord-010092-uftc8inx 10829 3 is be VBZ cord-010092-uftc8inx 10829 4 a a DT cord-010092-uftc8inx 10829 5 case case NN cord-010092-uftc8inx 10829 6 previously previously RB cord-010092-uftc8inx 10829 7 reported report VBD cord-010092-uftc8inx 10829 8 ( ( -LRB- cord-010092-uftc8inx 10829 9 Doyle Doyle NNP cord-010092-uftc8inx 10829 10 , , , cord-010092-uftc8inx 10829 11 Quigley Quigley NNP cord-010092-uftc8inx 10829 12 , , , cord-010092-uftc8inx 10829 13 Fitzgerald Fitzgerald NNP cord-010092-uftc8inx 10829 14 et et NNP cord-010092-uftc8inx 10829 15 . . . cord-010092-uftc8inx 10830 1 al al NNP cord-010092-uftc8inx 10830 2 . . . cord-010092-uftc8inx 10831 1 Transfusion Transfusion NNP cord-010092-uftc8inx 10831 2 Medicine Medicine NNP cord-010092-uftc8inx 10831 3 , , , cord-010092-uftc8inx 10831 4 2014 2014 CD cord-010092-uftc8inx 10831 5 ) ) -RRB- cord-010092-uftc8inx 10831 6 of of IN cord-010092-uftc8inx 10831 7 protracted protract VBN cord-010092-uftc8inx 10831 8 HDFN HDFN NNP cord-010092-uftc8inx 10831 9 due due IN cord-010092-uftc8inx 10831 10 to to IN cord-010092-uftc8inx 10831 11 anti anti JJ cord-010092-uftc8inx 10831 12 - - NN cord-010092-uftc8inx 10831 13 c c JJ cord-010092-uftc8inx 10831 14 , , , cord-010092-uftc8inx 10831 15 managed manage VBN cord-010092-uftc8inx 10831 16 with with IN cord-010092-uftc8inx 10831 17 phototherapy phototherapy NN cord-010092-uftc8inx 10831 18 initially initially RB cord-010092-uftc8inx 10831 19 , , , cord-010092-uftc8inx 10831 20 then then RB cord-010092-uftc8inx 10831 21 intervention intervention NN cord-010092-uftc8inx 10831 22 with with IN cord-010092-uftc8inx 10831 23 red red JJ cord-010092-uftc8inx 10831 24 cell cell NN cord-010092-uftc8inx 10831 25 top top RB cord-010092-uftc8inx 10831 26 - - HYPH cord-010092-uftc8inx 10831 27 up up RP cord-010092-uftc8inx 10831 28 transfusion transfusion NN cord-010092-uftc8inx 10831 29 at at IN cord-010092-uftc8inx 10831 30 4 4 CD cord-010092-uftc8inx 10831 31 weeks week NNS cord-010092-uftc8inx 10831 32 post post NN cord-010092-uftc8inx 10831 33 - - NN cord-010092-uftc8inx 10831 34 delivery delivery NN cord-010092-uftc8inx 10831 35 . . . cord-010092-uftc8inx 10832 1 The the DT cord-010092-uftc8inx 10832 2 second second JJ cord-010092-uftc8inx 10832 3 is be VBZ cord-010092-uftc8inx 10832 4 an an DT cord-010092-uftc8inx 10832 5 unusual unusual JJ cord-010092-uftc8inx 10832 6 case case NN cord-010092-uftc8inx 10832 7 of of IN cord-010092-uftc8inx 10832 8 severe severe JJ cord-010092-uftc8inx 10832 9 ABO ABO NNP cord-010092-uftc8inx 10832 10 HDFN HDFN NNP cord-010092-uftc8inx 10832 11 requiring require VBG cord-010092-uftc8inx 10832 12 exchange exchange NN cord-010092-uftc8inx 10832 13 transfusion transfusion NN cord-010092-uftc8inx 10832 14 therapy therapy NN cord-010092-uftc8inx 10832 15 ( ( -LRB- cord-010092-uftc8inx 10832 16 pre pre JJ cord-010092-uftc8inx 10832 17 - - NN cord-010092-uftc8inx 10832 18 publication publication NN cord-010092-uftc8inx 10832 19 ) ) -RRB- cord-010092-uftc8inx 10832 20 . . . cord-010092-uftc8inx 10833 1 Summary Summary NNP cord-010092-uftc8inx 10833 2 / / SYM cord-010092-uftc8inx 10833 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 10833 4 : : : cord-010092-uftc8inx 10834 1 Given give VBN cord-010092-uftc8inx 10834 2 the the DT cord-010092-uftc8inx 10834 3 increased increase VBN cord-010092-uftc8inx 10834 4 number number NN cord-010092-uftc8inx 10834 5 of of IN cord-010092-uftc8inx 10834 6 pregnancies pregnancy NNS cord-010092-uftc8inx 10834 7 conceived conceive VBN cord-010092-uftc8inx 10834 8 using use VBG cord-010092-uftc8inx 10834 9 DO DO NNP cord-010092-uftc8inx 10834 10 we -PRON- PRP cord-010092-uftc8inx 10834 11 recommend recommend VB cord-010092-uftc8inx 10834 12 that that IN cord-010092-uftc8inx 10834 13 antenatal antenatal JJ cord-010092-uftc8inx 10834 14 guidelines guideline NNS cord-010092-uftc8inx 10834 15 are be VBP cord-010092-uftc8inx 10834 16 reviewed review VBN cord-010092-uftc8inx 10834 17 to to TO cord-010092-uftc8inx 10834 18 create create VB cord-010092-uftc8inx 10834 19 awareness awareness NN cord-010092-uftc8inx 10834 20 regarding regard VBG cord-010092-uftc8inx 10834 21 the the DT cord-010092-uftc8inx 10834 22 potential potential JJ cord-010092-uftc8inx 10834 23 increased increase VBN cord-010092-uftc8inx 10834 24 risk risk NN cord-010092-uftc8inx 10834 25 of of IN cord-010092-uftc8inx 10834 26 HDFN HDFN NNP cord-010092-uftc8inx 10834 27 in in IN cord-010092-uftc8inx 10834 28 DO DO NNP cord-010092-uftc8inx 10834 29 pregnancies pregnancy NNS cord-010092-uftc8inx 10834 30 complicated complicate VBN cord-010092-uftc8inx 10834 31 by by IN cord-010092-uftc8inx 10834 32 allo allo NN cord-010092-uftc8inx 10834 33 - - HYPH cord-010092-uftc8inx 10834 34 immunisation immunisation NN cord-010092-uftc8inx 10834 35 . . . cord-010092-uftc8inx 10835 1 Critically critically RB cord-010092-uftc8inx 10835 2 , , , cord-010092-uftc8inx 10835 3 antenatal antenatal JJ cord-010092-uftc8inx 10835 4 testing testing NN cord-010092-uftc8inx 10835 5 guidelines guideline NNS cord-010092-uftc8inx 10835 6 should should MD cord-010092-uftc8inx 10835 7 highlight highlight VB cord-010092-uftc8inx 10835 8 that that IN cord-010092-uftc8inx 10835 9 the the DT cord-010092-uftc8inx 10835 10 predicted predict VBN cord-010092-uftc8inx 10835 11 outcomes outcome NNS cord-010092-uftc8inx 10835 12 associated associate VBN cord-010092-uftc8inx 10835 13 with with IN cord-010092-uftc8inx 10835 14 quantitation quantitation NN cord-010092-uftc8inx 10835 15 / / SYM cord-010092-uftc8inx 10835 16 titres titre NNS cord-010092-uftc8inx 10835 17 can can MD cord-010092-uftc8inx 10835 18 only only RB cord-010092-uftc8inx 10835 19 be be VB cord-010092-uftc8inx 10835 20 used use VBN cord-010092-uftc8inx 10835 21 when when WRB cord-010092-uftc8inx 10835 22 DO DO NNP cord-010092-uftc8inx 10835 23 has have VBZ cord-010092-uftc8inx 10835 24 not not RB cord-010092-uftc8inx 10835 25 been be VBN cord-010092-uftc8inx 10835 26 used use VBN cord-010092-uftc8inx 10835 27 to to TO cord-010092-uftc8inx 10835 28 obtain obtain VB cord-010092-uftc8inx 10835 29 the the DT cord-010092-uftc8inx 10835 30 pregnancy pregnancy NN cord-010092-uftc8inx 10835 31 . . . cord-010092-uftc8inx 10836 1 It -PRON- PRP cord-010092-uftc8inx 10836 2 is be VBZ cord-010092-uftc8inx 10836 3 also also RB cord-010092-uftc8inx 10836 4 essential essential JJ cord-010092-uftc8inx 10836 5 that that IN cord-010092-uftc8inx 10836 6 clinicians clinician NNS cord-010092-uftc8inx 10836 7 inform inform VBP cord-010092-uftc8inx 10836 8 the the DT cord-010092-uftc8inx 10836 9 blood blood NN cord-010092-uftc8inx 10836 10 transfusion transfusion NN cord-010092-uftc8inx 10836 11 laboratory laboratory NN cord-010092-uftc8inx 10836 12 when when WRB cord-010092-uftc8inx 10836 13 DO DO NNP cord-010092-uftc8inx 10836 14 has have VBZ cord-010092-uftc8inx 10836 15 been be VBN cord-010092-uftc8inx 10836 16 used use VBN cord-010092-uftc8inx 10836 17 . . . cord-010092-uftc8inx 10837 1 Abstract Abstract NNP cord-010092-uftc8inx 10837 2 withdrawn withdraw VBN cord-010092-uftc8inx 10837 3 . . . cord-010092-uftc8inx 10838 1 19 19 CD cord-010092-uftc8inx 10838 2 % % NN cord-010092-uftc8inx 10838 3 ) ) -RRB- cord-010092-uftc8inx 10838 4 are be VBP cord-010092-uftc8inx 10838 5 deceased decease VBN cord-010092-uftc8inx 10838 6 due due IN cord-010092-uftc8inx 10838 7 to to IN cord-010092-uftc8inx 10838 8 organ organ NN cord-010092-uftc8inx 10838 9 rejection rejection NN cord-010092-uftc8inx 10838 10 , , , cord-010092-uftc8inx 10838 11 and and CC cord-010092-uftc8inx 10838 12 8/36 8/36 CD cord-010092-uftc8inx 10838 13 patients patient NNS cord-010092-uftc8inx 10838 14 ( ( -LRB- cord-010092-uftc8inx 10838 15 22 22 CD cord-010092-uftc8inx 10838 16 % % NN cord-010092-uftc8inx 10838 17 ) ) -RRB- cord-010092-uftc8inx 10838 18 are be VBP cord-010092-uftc8inx 10838 19 deceased decease VBN cord-010092-uftc8inx 10838 20 due due IN cord-010092-uftc8inx 10838 21 to to IN cord-010092-uftc8inx 10838 22 disease disease NN cord-010092-uftc8inx 10838 23 not not RB cord-010092-uftc8inx 10838 24 related relate VBN cord-010092-uftc8inx 10838 25 to to IN cord-010092-uftc8inx 10838 26 rejection rejection NN cord-010092-uftc8inx 10838 27 . . . cord-010092-uftc8inx 10839 1 Summary Summary NNP cord-010092-uftc8inx 10839 2 / / SYM cord-010092-uftc8inx 10839 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 10839 4 : : : cord-010092-uftc8inx 10840 1 The the DT cord-010092-uftc8inx 10840 2 use use NN cord-010092-uftc8inx 10840 3 of of IN cord-010092-uftc8inx 10840 4 therapeutic therapeutic JJ cord-010092-uftc8inx 10840 5 plasma plasma NN cord-010092-uftc8inx 10840 6 exchange exchange NN cord-010092-uftc8inx 10840 7 for for IN cord-010092-uftc8inx 10840 8 the the DT cord-010092-uftc8inx 10840 9 treatment treatment NN cord-010092-uftc8inx 10840 10 of of IN cord-010092-uftc8inx 10840 11 antibody antibody NN cord-010092-uftc8inx 10840 12 mediated mediate VBN cord-010092-uftc8inx 10840 13 rejection rejection NN cord-010092-uftc8inx 10840 14 in in IN cord-010092-uftc8inx 10840 15 solid solid JJ cord-010092-uftc8inx 10840 16 organ organ NN cord-010092-uftc8inx 10840 17 transplant transplant NN cord-010092-uftc8inx 10840 18 is be VBZ cord-010092-uftc8inx 10840 19 safe safe JJ cord-010092-uftc8inx 10840 20 and and CC cord-010092-uftc8inx 10840 21 effective effective JJ cord-010092-uftc8inx 10840 22 when when WRB cord-010092-uftc8inx 10840 23 used use VBN cord-010092-uftc8inx 10840 24 along along RB cord-010092-uftc8inx 10840 25 with with IN cord-010092-uftc8inx 10840 26 other other JJ cord-010092-uftc8inx 10840 27 treatment treatment NN cord-010092-uftc8inx 10840 28 modalities modality NNS cord-010092-uftc8inx 10840 29 . . . cord-010092-uftc8inx 10841 1 Further further JJ cord-010092-uftc8inx 10841 2 studies study NNS cord-010092-uftc8inx 10841 3 will will MD cord-010092-uftc8inx 10841 4 help help VB cord-010092-uftc8inx 10841 5 determine determine VB cord-010092-uftc8inx 10841 6 whether whether IN cord-010092-uftc8inx 10841 7 it -PRON- PRP cord-010092-uftc8inx 10841 8 can can MD cord-010092-uftc8inx 10841 9 be be VB cord-010092-uftc8inx 10841 10 reproduced reproduce VBN cord-010092-uftc8inx 10841 11 in in IN cord-010092-uftc8inx 10841 12 larger large JJR cord-010092-uftc8inx 10841 13 cohorts cohort NNS cord-010092-uftc8inx 10841 14 and and CC cord-010092-uftc8inx 10841 15 whether whether IN cord-010092-uftc8inx 10841 16 it -PRON- PRP cord-010092-uftc8inx 10841 17 is be VBZ cord-010092-uftc8inx 10841 18 more more RBR cord-010092-uftc8inx 10841 19 effective effective JJ cord-010092-uftc8inx 10841 20 in in IN cord-010092-uftc8inx 10841 21 certain certain JJ cord-010092-uftc8inx 10841 22 organs organ NNS cord-010092-uftc8inx 10841 23 . . . cord-010092-uftc8inx 10842 1 Background background NN cord-010092-uftc8inx 10842 2 : : : cord-010092-uftc8inx 10843 1 Extracorporeal extracorporeal JJ cord-010092-uftc8inx 10843 2 Photopheresis Photopheresis NNP cord-010092-uftc8inx 10843 3 ( ( -LRB- cord-010092-uftc8inx 10843 4 ECP ECP NNP cord-010092-uftc8inx 10843 5 ) ) -RRB- cord-010092-uftc8inx 10843 6 is be VBZ cord-010092-uftc8inx 10843 7 an an DT cord-010092-uftc8inx 10843 8 important important JJ cord-010092-uftc8inx 10843 9 cellular cellular JJ cord-010092-uftc8inx 10843 10 therapy therapy NN cord-010092-uftc8inx 10843 11 for for IN cord-010092-uftc8inx 10843 12 the the DT cord-010092-uftc8inx 10843 13 treatment treatment NN cord-010092-uftc8inx 10843 14 of of IN cord-010092-uftc8inx 10843 15 several several JJ cord-010092-uftc8inx 10843 16 ( ( -LRB- cord-010092-uftc8inx 10843 17 auto-)immune auto-)immune NNP cord-010092-uftc8inx 10843 18 diseases disease NNS cord-010092-uftc8inx 10843 19 such such JJ cord-010092-uftc8inx 10843 20 as as IN cord-010092-uftc8inx 10843 21 graft graft NN cord-010092-uftc8inx 10843 22 - - HYPH cord-010092-uftc8inx 10843 23 versus versus IN cord-010092-uftc8inx 10843 24 - - HYPH cord-010092-uftc8inx 10843 25 host host NN cord-010092-uftc8inx 10843 26 disease disease NN cord-010092-uftc8inx 10843 27 . . . cord-010092-uftc8inx 10844 1 The the DT cord-010092-uftc8inx 10844 2 international international JJ cord-010092-uftc8inx 10844 3 standard standard NN cord-010092-uftc8inx 10844 4 for for IN cord-010092-uftc8inx 10844 5 the the DT cord-010092-uftc8inx 10844 6 ex ex FW cord-010092-uftc8inx 10844 7 vivo vivo NN cord-010092-uftc8inx 10844 8 treatment treatment NN cord-010092-uftc8inx 10844 9 of of IN cord-010092-uftc8inx 10844 10 the the DT cord-010092-uftc8inx 10844 11 leukapheresis leukapheresis NN cord-010092-uftc8inx 10844 12 product product NN cord-010092-uftc8inx 10844 13 is be VBZ cord-010092-uftc8inx 10844 14 the the DT cord-010092-uftc8inx 10844 15 application application NN cord-010092-uftc8inx 10844 16 of of IN cord-010092-uftc8inx 10844 17 8-Methoxypsoralen 8-methoxypsoralen CD cord-010092-uftc8inx 10844 18 ( ( -LRB- cord-010092-uftc8inx 10844 19 8-MOP 8-mop CD cord-010092-uftc8inx 10844 20 ) ) -RRB- cord-010092-uftc8inx 10844 21 and and CC cord-010092-uftc8inx 10844 22 irradiation irradiation NN cord-010092-uftc8inx 10844 23 with with IN cord-010092-uftc8inx 10844 24 UV uv NN cord-010092-uftc8inx 10844 25 - - HYPH cord-010092-uftc8inx 10844 26 A a DT cord-010092-uftc8inx 10844 27 light light NN cord-010092-uftc8inx 10844 28 . . . cord-010092-uftc8inx 10845 1 However however RB cord-010092-uftc8inx 10845 2 , , , cord-010092-uftc8inx 10845 3 the the DT cord-010092-uftc8inx 10845 4 addition addition NN cord-010092-uftc8inx 10845 5 of of IN cord-010092-uftc8inx 10845 6 8-MOP 8-mop CD cord-010092-uftc8inx 10845 7 to to IN cord-010092-uftc8inx 10845 8 the the DT cord-010092-uftc8inx 10845 9 illumination illumination NN cord-010092-uftc8inx 10845 10 bag bag NN cord-010092-uftc8inx 10845 11 is be VBZ cord-010092-uftc8inx 10845 12 associated associate VBN cord-010092-uftc8inx 10845 13 with with IN cord-010092-uftc8inx 10845 14 a a DT cord-010092-uftc8inx 10845 15 potential potential JJ cord-010092-uftc8inx 10845 16 risk risk NN cord-010092-uftc8inx 10845 17 of of IN cord-010092-uftc8inx 10845 18 contamination contamination NN cord-010092-uftc8inx 10845 19 . . . cord-010092-uftc8inx 10846 1 Aims aim VBZ cord-010092-uftc8inx 10846 2 : : : cord-010092-uftc8inx 10847 1 The the DT cord-010092-uftc8inx 10847 2 basic basic JJ cord-010092-uftc8inx 10847 3 principle principle NN cord-010092-uftc8inx 10847 4 of of IN cord-010092-uftc8inx 10847 5 the the DT cord-010092-uftc8inx 10847 6 ECP ECP NNP cord-010092-uftc8inx 10847 7 is be VBZ cord-010092-uftc8inx 10847 8 the the DT cord-010092-uftc8inx 10847 9 induction induction NN cord-010092-uftc8inx 10847 10 of of IN cord-010092-uftc8inx 10847 11 apoptosis apoptosis NN cord-010092-uftc8inx 10847 12 in in IN cord-010092-uftc8inx 10847 13 the the DT cord-010092-uftc8inx 10847 14 leukocytes leukocyte NNS cord-010092-uftc8inx 10847 15 . . . cord-010092-uftc8inx 10848 1 Our -PRON- PRP$ cord-010092-uftc8inx 10848 2 aim aim NN cord-010092-uftc8inx 10848 3 was be VBD cord-010092-uftc8inx 10848 4 to to TO cord-010092-uftc8inx 10848 5 find find VB cord-010092-uftc8inx 10848 6 an an DT cord-010092-uftc8inx 10848 7 alternative alternative NN cord-010092-uftc8inx 10848 8 for for IN cord-010092-uftc8inx 10848 9 the the DT cord-010092-uftc8inx 10848 10 conventional conventional JJ cord-010092-uftc8inx 10848 11 apoptosis apoptosis NN cord-010092-uftc8inx 10848 12 induction induction NN cord-010092-uftc8inx 10848 13 without without IN cord-010092-uftc8inx 10848 14 the the DT cord-010092-uftc8inx 10848 15 need need NN cord-010092-uftc8inx 10848 16 of of IN cord-010092-uftc8inx 10848 17 external external JJ cord-010092-uftc8inx 10848 18 substance substance NN cord-010092-uftc8inx 10848 19 application application NN cord-010092-uftc8inx 10848 20 . . . cord-010092-uftc8inx 10849 1 The the DT cord-010092-uftc8inx 10849 2 objective objective NN cord-010092-uftc8inx 10849 3 of of IN cord-010092-uftc8inx 10849 4 the the DT cord-010092-uftc8inx 10849 5 study study NN cord-010092-uftc8inx 10849 6 was be VBD cord-010092-uftc8inx 10849 7 the the DT cord-010092-uftc8inx 10849 8 investigation investigation NN cord-010092-uftc8inx 10849 9 of of IN cord-010092-uftc8inx 10849 10 the the DT cord-010092-uftc8inx 10849 11 apoptosis apoptosis NN cord-010092-uftc8inx 10849 12 levels level NNS cord-010092-uftc8inx 10849 13 and and CC cord-010092-uftc8inx 10849 14 kinetics kinetic NNS cord-010092-uftc8inx 10849 15 in in IN cord-010092-uftc8inx 10849 16 leukocytes leukocyte NNS cord-010092-uftc8inx 10849 17 after after IN cord-010092-uftc8inx 10849 18 treatment treatment NN cord-010092-uftc8inx 10849 19 with with IN cord-010092-uftc8inx 10849 20 8-MOP+UV 8-mop+uv CD cord-010092-uftc8inx 10849 21 - - HYPH cord-010092-uftc8inx 10849 22 A a NN cord-010092-uftc8inx 10849 23 compared compare VBN cord-010092-uftc8inx 10849 24 to to IN cord-010092-uftc8inx 10849 25 UV uv NN cord-010092-uftc8inx 10849 26 - - HYPH cord-010092-uftc8inx 10849 27 C c NN cord-010092-uftc8inx 10849 28 treatment treatment NN cord-010092-uftc8inx 10849 29 without without IN cord-010092-uftc8inx 10849 30 additional additional JJ cord-010092-uftc8inx 10849 31 8-MOP 8-mop CD cord-010092-uftc8inx 10849 32 . . . cord-010092-uftc8inx 10850 1 Methods method NNS cord-010092-uftc8inx 10850 2 : : : cord-010092-uftc8inx 10851 1 We -PRON- PRP cord-010092-uftc8inx 10851 2 used use VBD cord-010092-uftc8inx 10851 3 an an DT cord-010092-uftc8inx 10851 4 in in IN cord-010092-uftc8inx 10851 5 vitro vitro FW cord-010092-uftc8inx 10851 6 72 72 CD cord-010092-uftc8inx 10851 7 h h NN cord-010092-uftc8inx 10851 8 cell cell NN cord-010092-uftc8inx 10851 9 culture culture NN cord-010092-uftc8inx 10851 10 approach approach NN cord-010092-uftc8inx 10851 11 with with IN cord-010092-uftc8inx 10851 12 human human JJ cord-010092-uftc8inx 10851 13 mononuclear mononuclear NN cord-010092-uftc8inx 10851 14 cells cell NNS cord-010092-uftc8inx 10851 15 from from IN cord-010092-uftc8inx 10851 16 healthy healthy JJ cord-010092-uftc8inx 10851 17 blood blood NN cord-010092-uftc8inx 10851 18 donors donor NNS cord-010092-uftc8inx 10851 19 . . . cord-010092-uftc8inx 10852 1 Untreated untreated JJ cord-010092-uftc8inx 10852 2 control control NN cord-010092-uftc8inx 10852 3 cells cell NNS cord-010092-uftc8inx 10852 4 were be VBD cord-010092-uftc8inx 10852 5 compared compare VBN cord-010092-uftc8inx 10852 6 with with IN cord-010092-uftc8inx 10852 7 0,2 0,2 CD cord-010092-uftc8inx 10852 8 lg/ lg/ NN cord-010092-uftc8inx 10852 9 ml ml NNP cord-010092-uftc8inx 10852 10 8-MOP 8-mop CD cord-010092-uftc8inx 10852 11 plus plus CC cord-010092-uftc8inx 10852 12 2 2 CD cord-010092-uftc8inx 10852 13 J J NNP cord-010092-uftc8inx 10852 14 / / SYM cord-010092-uftc8inx 10852 15 cm cm NNP cord-010092-uftc8inx 10852 16 2 2 CD cord-010092-uftc8inx 10852 17 UV uv NN cord-010092-uftc8inx 10852 18 - - HYPH cord-010092-uftc8inx 10852 19 A a NN cord-010092-uftc8inx 10852 20 treated treat VBN cord-010092-uftc8inx 10852 21 cells cell NNS cord-010092-uftc8inx 10852 22 and and CC cord-010092-uftc8inx 10852 23 2 2 CD cord-010092-uftc8inx 10852 24 J J NNP cord-010092-uftc8inx 10852 25 / / SYM cord-010092-uftc8inx 10852 26 cm cm NNP cord-010092-uftc8inx 10852 27 2 2 CD cord-010092-uftc8inx 10852 28 ( ( -LRB- cord-010092-uftc8inx 10852 29 effective effective JJ cord-010092-uftc8inx 10852 30 dose dose NN cord-010092-uftc8inx 10852 31 ) ) -RRB- cord-010092-uftc8inx 10852 32 UV uv NN cord-010092-uftc8inx 10852 33 - - HYPH cord-010092-uftc8inx 10852 34 C c NN cord-010092-uftc8inx 10852 35 treated treat VBD cord-010092-uftc8inx 10852 36 cells cell NNS cord-010092-uftc8inx 10852 37 . . . cord-010092-uftc8inx 10853 1 Apoptosis apoptosis NN cord-010092-uftc8inx 10853 2 in in IN cord-010092-uftc8inx 10853 3 several several JJ cord-010092-uftc8inx 10853 4 leukocyte leukocyte NN cord-010092-uftc8inx 10853 5 sub sub NN cord-010092-uftc8inx 10853 6 - - NNS cord-010092-uftc8inx 10853 7 populations population NNS cord-010092-uftc8inx 10853 8 was be VBD cord-010092-uftc8inx 10853 9 detected detect VBN cord-010092-uftc8inx 10853 10 daily daily RB cord-010092-uftc8inx 10853 11 with with IN cord-010092-uftc8inx 10853 12 Annexin Annexin NNP cord-010092-uftc8inx 10853 13 V V NNP cord-010092-uftc8inx 10853 14 and and CC cord-010092-uftc8inx 10853 15 7-AAD 7-aad CD cord-010092-uftc8inx 10853 16 flow flow NN cord-010092-uftc8inx 10853 17 cytometry cytometry NN cord-010092-uftc8inx 10853 18 standings standing NNS cord-010092-uftc8inx 10853 19 . . . cord-010092-uftc8inx 10854 1 Results result NNS cord-010092-uftc8inx 10854 2 : : : cord-010092-uftc8inx 10855 1 The the DT cord-010092-uftc8inx 10855 2 apoptosis apoptosis NN cord-010092-uftc8inx 10855 3 analysis analysis NN cord-010092-uftc8inx 10855 4 of of IN cord-010092-uftc8inx 10855 5 CD3 CD3 NNP cord-010092-uftc8inx 10855 6 CD4 CD4 NNP cord-010092-uftc8inx 10855 7 T T NNP cord-010092-uftc8inx 10855 8 - - HYPH cord-010092-uftc8inx 10855 9 helper helper NN cord-010092-uftc8inx 10855 10 cells cell NNS cord-010092-uftc8inx 10855 11 , , , cord-010092-uftc8inx 10855 12 CD3 CD3 NNP cord-010092-uftc8inx 10855 13 CD8 CD8 NNP cord-010092-uftc8inx 10855 14 cytotoxic cytotoxic JJ cord-010092-uftc8inx 10855 15 Tcells Tcells NNP cord-010092-uftc8inx 10855 16 , , , cord-010092-uftc8inx 10855 17 CD19 CD19 NNP cord-010092-uftc8inx 10855 18 B B NNP cord-010092-uftc8inx 10855 19 - - HYPH cord-010092-uftc8inx 10855 20 cells cell NNS cord-010092-uftc8inx 10855 21 , , , cord-010092-uftc8inx 10855 22 CD14 CD14 NNP cord-010092-uftc8inx 10855 23 Monocytes Monocytes NNPS cord-010092-uftc8inx 10855 24 , , , cord-010092-uftc8inx 10855 25 CD3 CD3 NNP cord-010092-uftc8inx 10855 26 neg neg NNP cord-010092-uftc8inx 10855 27 CD56 CD56 NNP cord-010092-uftc8inx 10855 28 NK NK NNP cord-010092-uftc8inx 10855 29 - - HYPH cord-010092-uftc8inx 10855 30 cells cell NNS cord-010092-uftc8inx 10855 31 and and CC cord-010092-uftc8inx 10855 32 CD3 CD3 NNP cord-010092-uftc8inx 10855 33 CD56 CD56 NNP cord-010092-uftc8inx 10855 34 NKT NKT NNP cord-010092-uftc8inx 10855 35 cells cell NNS cord-010092-uftc8inx 10855 36 revealed reveal VBD cord-010092-uftc8inx 10855 37 no no DT cord-010092-uftc8inx 10855 38 statistical statistical JJ cord-010092-uftc8inx 10855 39 differences difference NNS cord-010092-uftc8inx 10855 40 in in IN cord-010092-uftc8inx 10855 41 almost almost RB cord-010092-uftc8inx 10855 42 all all DT cord-010092-uftc8inx 10855 43 of of IN cord-010092-uftc8inx 10855 44 these these DT cord-010092-uftc8inx 10855 45 cell cell NN cord-010092-uftc8inx 10855 46 types type NNS cord-010092-uftc8inx 10855 47 after after IN cord-010092-uftc8inx 10855 48 treatment treatment NN cord-010092-uftc8inx 10855 49 with with IN cord-010092-uftc8inx 10855 50 8-MOP 8-mop CD cord-010092-uftc8inx 10855 51 / / SYM cord-010092-uftc8inx 10855 52 UV uv NN cord-010092-uftc8inx 10855 53 - - HYPH cord-010092-uftc8inx 10855 54 A a NN cord-010092-uftc8inx 10855 55 or or CC cord-010092-uftc8inx 10855 56 UV uv NN cord-010092-uftc8inx 10855 57 - - HYPH cord-010092-uftc8inx 10855 58 C c NN cord-010092-uftc8inx 10855 59 light light NN cord-010092-uftc8inx 10855 60 . . . cord-010092-uftc8inx 10856 1 The the DT cord-010092-uftc8inx 10856 2 apoptosis apoptosis NN cord-010092-uftc8inx 10856 3 kinetic kinetic JJ cord-010092-uftc8inx 10856 4 as as RB cord-010092-uftc8inx 10856 5 well well RB cord-010092-uftc8inx 10856 6 as as IN cord-010092-uftc8inx 10856 7 the the DT cord-010092-uftc8inx 10856 8 final final JJ cord-010092-uftc8inx 10856 9 apoptosis apoptosis NN cord-010092-uftc8inx 10856 10 after after IN cord-010092-uftc8inx 10856 11 72 72 CD cord-010092-uftc8inx 10856 12 h h NN cord-010092-uftc8inx 10856 13 were be VBD cord-010092-uftc8inx 10856 14 similar similar JJ cord-010092-uftc8inx 10856 15 in in IN cord-010092-uftc8inx 10856 16 both both DT cord-010092-uftc8inx 10856 17 treatment treatment NN cord-010092-uftc8inx 10856 18 groups group NNS cord-010092-uftc8inx 10856 19 . . . cord-010092-uftc8inx 10857 1 Summary Summary NNP cord-010092-uftc8inx 10857 2 / / SYM cord-010092-uftc8inx 10857 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 10857 4 : : : cord-010092-uftc8inx 10858 1 The the DT cord-010092-uftc8inx 10858 2 addition addition NN cord-010092-uftc8inx 10858 3 of of IN cord-010092-uftc8inx 10858 4 8-MOP 8-mop CD cord-010092-uftc8inx 10858 5 to to IN cord-010092-uftc8inx 10858 6 the the DT cord-010092-uftc8inx 10858 7 photopheresis photopheresis NNP cord-010092-uftc8inx 10858 8 irradiation irradiation NN cord-010092-uftc8inx 10858 9 bag bag NN cord-010092-uftc8inx 10858 10 is be VBZ cord-010092-uftc8inx 10858 11 a a DT cord-010092-uftc8inx 10858 12 risk risk NN cord-010092-uftc8inx 10858 13 for for IN cord-010092-uftc8inx 10858 14 potential potential JJ cord-010092-uftc8inx 10858 15 infections infection NNS cord-010092-uftc8inx 10858 16 . . . cord-010092-uftc8inx 10859 1 The the DT cord-010092-uftc8inx 10859 2 main main JJ cord-010092-uftc8inx 10859 3 effect effect NN cord-010092-uftc8inx 10859 4 of of IN cord-010092-uftc8inx 10859 5 the the DT cord-010092-uftc8inx 10859 6 8-MOP 8-mop CD cord-010092-uftc8inx 10859 7 / / SYM cord-010092-uftc8inx 10859 8 UV uv NN cord-010092-uftc8inx 10859 9 - - HYPH cord-010092-uftc8inx 10859 10 A a DT cord-010092-uftc8inx 10859 11 treatment treatment NN cord-010092-uftc8inx 10859 12 is be VBZ cord-010092-uftc8inx 10859 13 most most RBS cord-010092-uftc8inx 10859 14 probably probably RB cord-010092-uftc8inx 10859 15 the the DT cord-010092-uftc8inx 10859 16 induction induction NN cord-010092-uftc8inx 10859 17 of of IN cord-010092-uftc8inx 10859 18 apoptosis apoptosis NN cord-010092-uftc8inx 10859 19 in in IN cord-010092-uftc8inx 10859 20 the the DT cord-010092-uftc8inx 10859 21 leukocytes leukocyte NNS cord-010092-uftc8inx 10859 22 . . . cord-010092-uftc8inx 10860 1 Here here RB cord-010092-uftc8inx 10860 2 , , , cord-010092-uftc8inx 10860 3 we -PRON- PRP cord-010092-uftc8inx 10860 4 provide provide VBP cord-010092-uftc8inx 10860 5 information information NN cord-010092-uftc8inx 10860 6 that that IN cord-010092-uftc8inx 10860 7 this this DT cord-010092-uftc8inx 10860 8 induction induction NN cord-010092-uftc8inx 10860 9 of of IN cord-010092-uftc8inx 10860 10 apoptosis apoptosis NN cord-010092-uftc8inx 10860 11 can can MD cord-010092-uftc8inx 10860 12 also also RB cord-010092-uftc8inx 10860 13 be be VB cord-010092-uftc8inx 10860 14 achieved achieve VBN cord-010092-uftc8inx 10860 15 with with IN cord-010092-uftc8inx 10860 16 UV uv NN cord-010092-uftc8inx 10860 17 - - HYPH cord-010092-uftc8inx 10860 18 C c NN cord-010092-uftc8inx 10860 19 irradiation irradiation NN cord-010092-uftc8inx 10860 20 without without IN cord-010092-uftc8inx 10860 21 the the DT cord-010092-uftc8inx 10860 22 need need NN cord-010092-uftc8inx 10860 23 of of IN cord-010092-uftc8inx 10860 24 8-MOP 8-mop CD cord-010092-uftc8inx 10860 25 addition addition NN cord-010092-uftc8inx 10860 26 . . . cord-010092-uftc8inx 10861 1 The the DT cord-010092-uftc8inx 10861 2 apoptosis apoptosis NN cord-010092-uftc8inx 10861 3 patterns pattern NNS cord-010092-uftc8inx 10861 4 in in IN cord-010092-uftc8inx 10861 5 most most JJS cord-010092-uftc8inx 10861 6 leukocyte leukocyte NN cord-010092-uftc8inx 10861 7 subpopulations subpopulation NNS cord-010092-uftc8inx 10861 8 are be VBP cord-010092-uftc8inx 10861 9 very very RB cord-010092-uftc8inx 10861 10 similar similar JJ cord-010092-uftc8inx 10861 11 after after IN cord-010092-uftc8inx 10861 12 treatment treatment NN cord-010092-uftc8inx 10861 13 with with IN cord-010092-uftc8inx 10861 14 UV uv NN cord-010092-uftc8inx 10861 15 - - HYPH cord-010092-uftc8inx 10861 16 C c NN cord-010092-uftc8inx 10861 17 compared compare VBN cord-010092-uftc8inx 10861 18 with with IN cord-010092-uftc8inx 10861 19 8-MOP 8-mop CD cord-010092-uftc8inx 10861 20 / / SYM cord-010092-uftc8inx 10861 21 UV uv NN cord-010092-uftc8inx 10861 22 - - HYPH cord-010092-uftc8inx 10861 23 A a DT cord-010092-uftc8inx 10861 24 treatment treatment NN cord-010092-uftc8inx 10861 25 . . . cord-010092-uftc8inx 10862 1 Future future NN cord-010092-uftc8inx 10862 2 in in IN cord-010092-uftc8inx 10862 3 vivo vivo NN cord-010092-uftc8inx 10862 4 studies study NNS cord-010092-uftc8inx 10862 5 are be VBP cord-010092-uftc8inx 10862 6 needed need VBN cord-010092-uftc8inx 10862 7 to to TO cord-010092-uftc8inx 10862 8 prove prove VB cord-010092-uftc8inx 10862 9 the the DT cord-010092-uftc8inx 10862 10 therapeutic therapeutic JJ cord-010092-uftc8inx 10862 11 effect effect NN cord-010092-uftc8inx 10862 12 of of IN cord-010092-uftc8inx 10862 13 UV uv NN cord-010092-uftc8inx 10862 14 - - HYPH cord-010092-uftc8inx 10862 15 C c NN cord-010092-uftc8inx 10862 16 treated treat VBD cord-010092-uftc8inx 10862 17 cells cell NNS cord-010092-uftc8inx 10862 18 in in IN cord-010092-uftc8inx 10862 19 the the DT cord-010092-uftc8inx 10862 20 ECP ECP NNP cord-010092-uftc8inx 10862 21 setting setting NN cord-010092-uftc8inx 10862 22 . . . cord-010092-uftc8inx 10863 1 Abstract Abstract NNP cord-010092-uftc8inx 10863 2 withdrawn withdraw VBN cord-010092-uftc8inx 10863 3 . . . cord-010092-uftc8inx 10864 1 Background background NN cord-010092-uftc8inx 10864 2 : : : cord-010092-uftc8inx 10865 1 Therapeutic Therapeutic NNP cord-010092-uftc8inx 10865 2 Plasma Plasma NNP cord-010092-uftc8inx 10865 3 exchange exchange NN cord-010092-uftc8inx 10865 4 ( ( -LRB- cord-010092-uftc8inx 10865 5 TPE TPE NNP cord-010092-uftc8inx 10865 6 ) ) -RRB- cord-010092-uftc8inx 10865 7 is be VBZ cord-010092-uftc8inx 10865 8 performed perform VBN cord-010092-uftc8inx 10865 9 to to TO cord-010092-uftc8inx 10865 10 remove remove VB cord-010092-uftc8inx 10865 11 the the DT cord-010092-uftc8inx 10865 12 implicating implicate VBG cord-010092-uftc8inx 10865 13 substances substance NNS cord-010092-uftc8inx 10865 14 from from IN cord-010092-uftc8inx 10865 15 the the DT cord-010092-uftc8inx 10865 16 plasma plasma NN cord-010092-uftc8inx 10865 17 causing cause VBG cord-010092-uftc8inx 10865 18 the the DT cord-010092-uftc8inx 10865 19 disease disease NN cord-010092-uftc8inx 10865 20 . . . cord-010092-uftc8inx 10866 1 A a DT cord-010092-uftc8inx 10866 2 periodic periodic JJ cord-010092-uftc8inx 10866 3 appraisal appraisal NN cord-010092-uftc8inx 10866 4 of of IN cord-010092-uftc8inx 10866 5 TPE TPE NNP cord-010092-uftc8inx 10866 6 data datum NNS cord-010092-uftc8inx 10866 7 is be VBZ cord-010092-uftc8inx 10866 8 important important JJ cord-010092-uftc8inx 10866 9 to to TO cord-010092-uftc8inx 10866 10 get get VB cord-010092-uftc8inx 10866 11 insight insight NN cord-010092-uftc8inx 10866 12 into into IN cord-010092-uftc8inx 10866 13 the the DT cord-010092-uftc8inx 10866 14 procedural procedural JJ cord-010092-uftc8inx 10866 15 related relate VBN cord-010092-uftc8inx 10866 16 effects effect NNS cord-010092-uftc8inx 10866 17 and and CC cord-010092-uftc8inx 10866 18 toxicities toxicity NNS cord-010092-uftc8inx 10866 19 and and CC cord-010092-uftc8inx 10866 20 overall overall JJ cord-010092-uftc8inx 10866 21 outcome outcome NN cord-010092-uftc8inx 10866 22 in in IN cord-010092-uftc8inx 10866 23 order order NN cord-010092-uftc8inx 10866 24 to to TO cord-010092-uftc8inx 10866 25 have have VB cord-010092-uftc8inx 10866 26 a a DT cord-010092-uftc8inx 10866 27 guided guide VBN cord-010092-uftc8inx 10866 28 future future JJ cord-010092-uftc8inx 10866 29 approach approach NN cord-010092-uftc8inx 10866 30 . . . cord-010092-uftc8inx 10867 1 Aims aim VBZ cord-010092-uftc8inx 10867 2 : : : cord-010092-uftc8inx 10868 1 The the DT cord-010092-uftc8inx 10868 2 purpose purpose NN cord-010092-uftc8inx 10868 3 of of IN cord-010092-uftc8inx 10868 4 this this DT cord-010092-uftc8inx 10868 5 study study NN cord-010092-uftc8inx 10868 6 is be VBZ cord-010092-uftc8inx 10868 7 to to TO cord-010092-uftc8inx 10868 8 observe observe VB cord-010092-uftc8inx 10868 9 the the DT cord-010092-uftc8inx 10868 10 overall overall JJ cord-010092-uftc8inx 10868 11 profile profile NN cord-010092-uftc8inx 10868 12 and and CC cord-010092-uftc8inx 10868 13 outcome outcome NN cord-010092-uftc8inx 10868 14 of of IN cord-010092-uftc8inx 10868 15 the the DT cord-010092-uftc8inx 10868 16 patients patient NNS cord-010092-uftc8inx 10868 17 receiving receive VBG cord-010092-uftc8inx 10868 18 the the DT cord-010092-uftc8inx 10868 19 TPE TPE NNP cord-010092-uftc8inx 10868 20 in in IN cord-010092-uftc8inx 10868 21 the the DT cord-010092-uftc8inx 10868 22 Medicine Medicine NNP cord-010092-uftc8inx 10868 23 Intensive Intensive NNP cord-010092-uftc8inx 10868 24 Care Care NNP cord-010092-uftc8inx 10868 25 Unit Unit NNP cord-010092-uftc8inx 10868 26 ( ( -LRB- cord-010092-uftc8inx 10868 27 MICU MICU NNP cord-010092-uftc8inx 10868 28 ) ) -RRB- cord-010092-uftc8inx 10868 29 of of IN cord-010092-uftc8inx 10868 30 a a DT cord-010092-uftc8inx 10868 31 tertiary tertiary JJ cord-010092-uftc8inx 10868 32 care care NN cord-010092-uftc8inx 10868 33 hospital hospital NN cord-010092-uftc8inx 10868 34 in in IN cord-010092-uftc8inx 10868 35 South South NNP cord-010092-uftc8inx 10868 36 India India NNP cord-010092-uftc8inx 10868 37 . . . cord-010092-uftc8inx 10869 1 Methods method NNS cord-010092-uftc8inx 10869 2 : : : cord-010092-uftc8inx 10870 1 A a DT cord-010092-uftc8inx 10870 2 record record NN cord-010092-uftc8inx 10870 3 based base VBN cord-010092-uftc8inx 10870 4 audit audit NN cord-010092-uftc8inx 10870 5 was be VBD cord-010092-uftc8inx 10870 6 conducted conduct VBN cord-010092-uftc8inx 10870 7 for for IN cord-010092-uftc8inx 10870 8 the the DT cord-010092-uftc8inx 10870 9 all all PDT cord-010092-uftc8inx 10870 10 the the DT cord-010092-uftc8inx 10870 11 patients patient NNS cord-010092-uftc8inx 10870 12 who who WP cord-010092-uftc8inx 10870 13 were be VBD cord-010092-uftc8inx 10870 14 admitted admit VBN cord-010092-uftc8inx 10870 15 to to IN cord-010092-uftc8inx 10870 16 our -PRON- PRP$ cord-010092-uftc8inx 10870 17 tertiary tertiary JJ cord-010092-uftc8inx 10870 18 care care NN cord-010092-uftc8inx 10870 19 hospital hospital NN cord-010092-uftc8inx 10870 20 of of IN cord-010092-uftc8inx 10870 21 South South NNP cord-010092-uftc8inx 10870 22 India India NNP cord-010092-uftc8inx 10870 23 with with IN cord-010092-uftc8inx 10870 24 16 16 CD cord-010092-uftc8inx 10870 25 bedded bed VBN cord-010092-uftc8inx 10870 26 MICU MICU NNP cord-010092-uftc8inx 10870 27 and and CC cord-010092-uftc8inx 10870 28 received receive VBD cord-010092-uftc8inx 10870 29 TPE TPE NNP cord-010092-uftc8inx 10870 30 therapy therapy NN cord-010092-uftc8inx 10870 31 between between IN cord-010092-uftc8inx 10870 32 1 1 CD cord-010092-uftc8inx 10870 33 June June NNP cord-010092-uftc8inx 10870 34 , , , cord-010092-uftc8inx 10870 35 2016 2016 CD cord-010092-uftc8inx 10870 36 and and CC cord-010092-uftc8inx 10870 37 31 31 CD cord-010092-uftc8inx 10870 38 December December NNP cord-010092-uftc8inx 10870 39 2018 2018 CD cord-010092-uftc8inx 10870 40 . . . cord-010092-uftc8inx 10871 1 All all PDT cord-010092-uftc8inx 10871 2 the the DT cord-010092-uftc8inx 10871 3 TPE TPE NNP cord-010092-uftc8inx 10871 4 procedures procedure NNS cord-010092-uftc8inx 10871 5 were be VBD cord-010092-uftc8inx 10871 6 performed perform VBN cord-010092-uftc8inx 10871 7 using use VBG cord-010092-uftc8inx 10871 8 Haemonetics Haemonetics NNP cord-010092-uftc8inx 10871 9 Multicomponents Multicomponents NNP cord-010092-uftc8inx 10871 10 System System NNP cord-010092-uftc8inx 10871 11 ( ( -LRB- cord-010092-uftc8inx 10871 12 MCS MCS NNP cord-010092-uftc8inx 10871 13 ) ) -RRB- cord-010092-uftc8inx 10871 14 + + . cord-010092-uftc8inx 10871 15 LN9000 ln9000 NN cord-010092-uftc8inx 10871 16 apheresis apheresis NN cord-010092-uftc8inx 10871 17 system system NN cord-010092-uftc8inx 10871 18 based base VBN cord-010092-uftc8inx 10871 19 on on IN cord-010092-uftc8inx 10871 20 intermittent intermittent JJ cord-010092-uftc8inx 10871 21 flow flow NN cord-010092-uftc8inx 10871 22 centrifugation centrifugation NN cord-010092-uftc8inx 10871 23 . . . cord-010092-uftc8inx 10872 1 We -PRON- PRP cord-010092-uftc8inx 10872 2 audited audit VBD cord-010092-uftc8inx 10872 3 our -PRON- PRP$ cord-010092-uftc8inx 10872 4 TPE tpe NN cord-010092-uftc8inx 10872 5 for for IN cord-010092-uftc8inx 10872 6 : : : cord-010092-uftc8inx 10872 7 number number NN cord-010092-uftc8inx 10872 8 of of IN cord-010092-uftc8inx 10872 9 treatments treatment NNS cord-010092-uftc8inx 10872 10 , , , cord-010092-uftc8inx 10872 11 clinical clinical JJ cord-010092-uftc8inx 10872 12 indications indication NNS cord-010092-uftc8inx 10872 13 , , , cord-010092-uftc8inx 10872 14 treatments treatment NNS cord-010092-uftc8inx 10872 15 prescribed prescribe VBN cord-010092-uftc8inx 10872 16 and and CC cord-010092-uftc8inx 10872 17 administered administer VBN cord-010092-uftc8inx 10872 18 , , , cord-010092-uftc8inx 10872 19 any any DT cord-010092-uftc8inx 10872 20 procedural procedural JJ cord-010092-uftc8inx 10872 21 or or CC cord-010092-uftc8inx 10872 22 patient patient JJ cord-010092-uftc8inx 10872 23 complications complication NNS cord-010092-uftc8inx 10872 24 , , , cord-010092-uftc8inx 10872 25 and and CC cord-010092-uftc8inx 10872 26 adherence adherence NN cord-010092-uftc8inx 10872 27 to to IN cord-010092-uftc8inx 10872 28 current current JJ cord-010092-uftc8inx 10872 29 best good JJS cord-010092-uftc8inx 10872 30 practice practice NN cord-010092-uftc8inx 10872 31 recommendations recommendation NNS cord-010092-uftc8inx 10872 32 . . . cord-010092-uftc8inx 10873 1 Results result NNS cord-010092-uftc8inx 10873 2 : : : cord-010092-uftc8inx 10874 1 Sixty sixty CD cord-010092-uftc8inx 10874 2 nine nine CD cord-010092-uftc8inx 10874 3 patients patient NNS cord-010092-uftc8inx 10874 4 had have VBD cord-010092-uftc8inx 10874 5 undergone undergo VBN cord-010092-uftc8inx 10874 6 269 269 CD cord-010092-uftc8inx 10874 7 TPE TPE NNP cord-010092-uftc8inx 10874 8 procedures procedure NNS cord-010092-uftc8inx 10874 9 . . . cord-010092-uftc8inx 10875 1 Among among IN cord-010092-uftc8inx 10875 2 them -PRON- PRP cord-010092-uftc8inx 10875 3 , , , cord-010092-uftc8inx 10875 4 thirty thirty CD cord-010092-uftc8inx 10875 5 were be VBD cord-010092-uftc8inx 10875 6 female female JJ cord-010092-uftc8inx 10875 7 patients patient NNS cord-010092-uftc8inx 10875 8 ( ( -LRB- cord-010092-uftc8inx 10875 9 43 43 CD cord-010092-uftc8inx 10875 10 % % NN cord-010092-uftc8inx 10875 11 ) ) -RRB- cord-010092-uftc8inx 10875 12 . . . cord-010092-uftc8inx 10876 1 The the DT cord-010092-uftc8inx 10876 2 median median JJ cord-010092-uftc8inx 10876 3 age age NN cord-010092-uftc8inx 10876 4 45 45 CD cord-010092-uftc8inx 10876 5 ( ( -LRB- cord-010092-uftc8inx 10876 6 13 13 CD cord-010092-uftc8inx 10876 7 - - SYM cord-010092-uftc8inx 10876 8 75 75 CD cord-010092-uftc8inx 10876 9 ) ) -RRB- cord-010092-uftc8inx 10876 10 years year NNS cord-010092-uftc8inx 10876 11 . . . cord-010092-uftc8inx 10877 1 Guillain Guillain NNP cord-010092-uftc8inx 10877 2 - - HYPH cord-010092-uftc8inx 10877 3 Barre Barre NNP cord-010092-uftc8inx 10877 4 Syndrome Syndrome NNP cord-010092-uftc8inx 10877 5 ( ( -LRB- cord-010092-uftc8inx 10877 6 GBS GBS NNP cord-010092-uftc8inx 10877 7 ) ) -RRB- cord-010092-uftc8inx 10877 8 was be VBD cord-010092-uftc8inx 10877 9 the the DT cord-010092-uftc8inx 10877 10 most most RBS cord-010092-uftc8inx 10877 11 common common JJ cord-010092-uftc8inx 10877 12 indication indication NN cord-010092-uftc8inx 10877 13 ( ( -LRB- cord-010092-uftc8inx 10877 14 72 72 CD cord-010092-uftc8inx 10877 15 % % NN cord-010092-uftc8inx 10877 16 ) ) -RRB- cord-010092-uftc8inx 10877 17 followed follow VBN cord-010092-uftc8inx 10877 18 by by IN cord-010092-uftc8inx 10877 19 cases case NNS cord-010092-uftc8inx 10877 20 of of IN cord-010092-uftc8inx 10877 21 Thrombotic thrombotic JJ cord-010092-uftc8inx 10877 22 thrombocytopenic thrombocytopenic JJ cord-010092-uftc8inx 10877 23 purpura purpura NN cord-010092-uftc8inx 10877 24 , , , cord-010092-uftc8inx 10877 25 diffuse diffuse VB cord-010092-uftc8inx 10877 26 alveolar alveolar NN cord-010092-uftc8inx 10877 27 hemorrhage hemorrhage NN cord-010092-uftc8inx 10877 28 , , , cord-010092-uftc8inx 10877 29 myasthenia myasthenia NN cord-010092-uftc8inx 10877 30 gravis gravis NN cord-010092-uftc8inx 10877 31 , , , cord-010092-uftc8inx 10877 32 autoimmune autoimmune JJ cord-010092-uftc8inx 10877 33 encephalitis encephalitis NN cord-010092-uftc8inx 10877 34 and and CC cord-010092-uftc8inx 10877 35 hypertriglyceridemia hypertriglyceridemia NN cord-010092-uftc8inx 10877 36 respectively respectively RB cord-010092-uftc8inx 10877 37 . . . cord-010092-uftc8inx 10878 1 The the DT cord-010092-uftc8inx 10878 2 TPE TPE NNP cord-010092-uftc8inx 10878 3 regimens regimen NNS cord-010092-uftc8inx 10878 4 received receive VBN cord-010092-uftc8inx 10878 5 by by IN cord-010092-uftc8inx 10878 6 patients patient NNS cord-010092-uftc8inx 10878 7 in in IN cord-010092-uftc8inx 10878 8 this this DT cord-010092-uftc8inx 10878 9 ICU ICU NNP cord-010092-uftc8inx 10878 10 were be VBD cord-010092-uftc8inx 10878 11 not not RB cord-010092-uftc8inx 10878 12 always always RB cord-010092-uftc8inx 10878 13 prescribed prescribe VBN cord-010092-uftc8inx 10878 14 in in IN cord-010092-uftc8inx 10878 15 accordance accordance NN cord-010092-uftc8inx 10878 16 with with IN cord-010092-uftc8inx 10878 17 current current JJ cord-010092-uftc8inx 10878 18 best good JJS cord-010092-uftc8inx 10878 19 practice practice NN cord-010092-uftc8inx 10878 20 recommendations recommendation NNS cord-010092-uftc8inx 10878 21 . . . cord-010092-uftc8inx 10879 1 There there EX cord-010092-uftc8inx 10879 2 were be VBD cord-010092-uftc8inx 10879 3 48 48 CD cord-010092-uftc8inx 10879 4 ( ( -LRB- cord-010092-uftc8inx 10879 5 18 18 CD cord-010092-uftc8inx 10879 6 % % NN cord-010092-uftc8inx 10879 7 ) ) -RRB- cord-010092-uftc8inx 10879 8 episodes episode NNS cord-010092-uftc8inx 10879 9 of of IN cord-010092-uftc8inx 10879 10 patient patient JJ cord-010092-uftc8inx 10879 11 related relate VBN cord-010092-uftc8inx 10879 12 complications complication NNS cord-010092-uftc8inx 10879 13 during during IN cord-010092-uftc8inx 10879 14 the the DT cord-010092-uftc8inx 10879 15 TPE TPE NNP cord-010092-uftc8inx 10879 16 treatments treatment NNS cord-010092-uftc8inx 10879 17 . . . cord-010092-uftc8inx 10880 1 In in IN cord-010092-uftc8inx 10880 2 8 8 CD cord-010092-uftc8inx 10880 3 ( ( -LRB- cord-010092-uftc8inx 10880 4 3 3 CD cord-010092-uftc8inx 10880 5 % % NN cord-010092-uftc8inx 10880 6 ) ) -RRB- cord-010092-uftc8inx 10880 7 procedures procedure NNS cord-010092-uftc8inx 10880 8 , , , cord-010092-uftc8inx 10880 9 technical technical JJ cord-010092-uftc8inx 10880 10 error error NN cord-010092-uftc8inx 10880 11 in in IN cord-010092-uftc8inx 10880 12 the the DT cord-010092-uftc8inx 10880 13 machine machine NN cord-010092-uftc8inx 10880 14 was be VBD cord-010092-uftc8inx 10880 15 encountered encounter VBN cord-010092-uftc8inx 10880 16 . . . cord-010092-uftc8inx 10881 1 Summary Summary NNP cord-010092-uftc8inx 10881 2 / / SYM cord-010092-uftc8inx 10881 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 10881 4 : : : cord-010092-uftc8inx 10882 1 The the DT cord-010092-uftc8inx 10882 2 findings finding NNS cord-010092-uftc8inx 10882 3 of of IN cord-010092-uftc8inx 10882 4 this this DT cord-010092-uftc8inx 10882 5 audit audit NN cord-010092-uftc8inx 10882 6 have have VBP cord-010092-uftc8inx 10882 7 identified identify VBN cord-010092-uftc8inx 10882 8 differences difference NNS cord-010092-uftc8inx 10882 9 between between IN cord-010092-uftc8inx 10882 10 the the DT cord-010092-uftc8inx 10882 11 current current JJ cord-010092-uftc8inx 10882 12 prescription prescription NN cord-010092-uftc8inx 10882 13 recommendations recommendation NNS cord-010092-uftc8inx 10882 14 for for IN cord-010092-uftc8inx 10882 15 TPE TPE NNP cord-010092-uftc8inx 10882 16 and and CC cord-010092-uftc8inx 10882 17 those those DT cord-010092-uftc8inx 10882 18 applied apply VBN cord-010092-uftc8inx 10882 19 . . . cord-010092-uftc8inx 10883 1 The the DT cord-010092-uftc8inx 10883 2 infrequency infrequency NN cord-010092-uftc8inx 10883 3 of of IN cord-010092-uftc8inx 10883 4 the the DT cord-010092-uftc8inx 10883 5 therapy therapy NN cord-010092-uftc8inx 10883 6 and and CC cord-010092-uftc8inx 10883 7 the the DT cord-010092-uftc8inx 10883 8 different different JJ cord-010092-uftc8inx 10883 9 indications indication NNS cord-010092-uftc8inx 10883 10 may may MD cord-010092-uftc8inx 10883 11 present present VB cord-010092-uftc8inx 10883 12 a a DT cord-010092-uftc8inx 10883 13 challenge challenge NN cord-010092-uftc8inx 10883 14 for for IN cord-010092-uftc8inx 10883 15 Medicine Medicine NNP cord-010092-uftc8inx 10883 16 Intensive Intensive NNP cord-010092-uftc8inx 10883 17 Care Care NNP cord-010092-uftc8inx 10883 18 clinicians clinician NNS cord-010092-uftc8inx 10883 19 to to TO cord-010092-uftc8inx 10883 20 provide provide VB cord-010092-uftc8inx 10883 21 best good JJS cord-010092-uftc8inx 10883 22 care care NN cord-010092-uftc8inx 10883 23 in in IN cord-010092-uftc8inx 10883 24 all all DT cord-010092-uftc8inx 10883 25 cases case NNS cord-010092-uftc8inx 10883 26 . . . cord-010092-uftc8inx 10884 1 Background background NN cord-010092-uftc8inx 10884 2 : : : cord-010092-uftc8inx 10885 1 Microangiopathic microangiopathic JJ cord-010092-uftc8inx 10885 2 hemolytic hemolytic JJ cord-010092-uftc8inx 10885 3 anaemia anaemia NN cord-010092-uftc8inx 10885 4 ( ( -LRB- cord-010092-uftc8inx 10885 5 MAHA MAHA NNP cord-010092-uftc8inx 10885 6 ) ) -RRB- cord-010092-uftc8inx 10885 7 encompasses encompass VBZ cord-010092-uftc8inx 10885 8 a a DT cord-010092-uftc8inx 10885 9 spectrum spectrum NN cord-010092-uftc8inx 10885 10 of of IN cord-010092-uftc8inx 10885 11 disorders disorder NNS cord-010092-uftc8inx 10885 12 characterised characterise VBN cord-010092-uftc8inx 10885 13 by by IN cord-010092-uftc8inx 10885 14 widely widely RB cord-010092-uftc8inx 10885 15 disseminated disseminate VBN cord-010092-uftc8inx 10885 16 thrombosis thrombosis NN cord-010092-uftc8inx 10885 17 in in IN cord-010092-uftc8inx 10885 18 small small JJ cord-010092-uftc8inx 10885 19 blood blood NN cord-010092-uftc8inx 10885 20 vessels vessel NNS cord-010092-uftc8inx 10885 21 resulting result VBG cord-010092-uftc8inx 10885 22 in in IN cord-010092-uftc8inx 10885 23 formation formation NN cord-010092-uftc8inx 10885 24 of of IN cord-010092-uftc8inx 10885 25 schistocytes schistocyte NNS cord-010092-uftc8inx 10885 26 and and CC cord-010092-uftc8inx 10885 27 concomitant concomitant JJ cord-010092-uftc8inx 10885 28 thrombocytopenia thrombocytopenia NN cord-010092-uftc8inx 10885 29 . . . cord-010092-uftc8inx 10886 1 Plasma plasma NN cord-010092-uftc8inx 10886 2 exchange exchange NN cord-010092-uftc8inx 10886 3 ( ( -LRB- cord-010092-uftc8inx 10886 4 PE pe NN cord-010092-uftc8inx 10886 5 ) ) -RRB- cord-010092-uftc8inx 10886 6 needs need VBZ cord-010092-uftc8inx 10886 7 to to TO cord-010092-uftc8inx 10886 8 be be VB cord-010092-uftc8inx 10886 9 considered consider VBN cord-010092-uftc8inx 10886 10 as as IN cord-010092-uftc8inx 10886 11 empirical empirical JJ cord-010092-uftc8inx 10886 12 and and CC cord-010092-uftc8inx 10886 13 urgent urgent JJ cord-010092-uftc8inx 10886 14 life life NN cord-010092-uftc8inx 10886 15 saving save VBG cord-010092-uftc8inx 10886 16 therapy therapy NN cord-010092-uftc8inx 10886 17 in in IN cord-010092-uftc8inx 10886 18 these these DT cord-010092-uftc8inx 10886 19 disorders disorder NNS cord-010092-uftc8inx 10886 20 irrespective irrespective RB cord-010092-uftc8inx 10886 21 of of IN cord-010092-uftc8inx 10886 22 waiting wait VBG cord-010092-uftc8inx 10886 23 for for IN cord-010092-uftc8inx 10886 24 specific specific JJ cord-010092-uftc8inx 10886 25 testing testing NN cord-010092-uftc8inx 10886 26 like like IN cord-010092-uftc8inx 10886 27 ADAMTS ADAMTS NNP cord-010092-uftc8inx 10886 28 13 13 CD cord-010092-uftc8inx 10886 29 levels level NNS cord-010092-uftc8inx 10886 30 in in IN cord-010092-uftc8inx 10886 31 Thrombotic thrombotic JJ cord-010092-uftc8inx 10886 32 thrombocytopenic thrombocytopenic JJ cord-010092-uftc8inx 10886 33 purpura purpura NN cord-010092-uftc8inx 10886 34 ( ( -LRB- cord-010092-uftc8inx 10886 35 TTP TTP NNP cord-010092-uftc8inx 10886 36 ) ) -RRB- cord-010092-uftc8inx 10886 37 or or CC cord-010092-uftc8inx 10886 38 Complement complement JJ cord-010092-uftc8inx 10886 39 levels level NNS cord-010092-uftc8inx 10886 40 or or CC cord-010092-uftc8inx 10886 41 factor factor NN cord-010092-uftc8inx 10886 42 H h NN cord-010092-uftc8inx 10886 43 antibodies antibody NNS cord-010092-uftc8inx 10886 44 in in IN cord-010092-uftc8inx 10886 45 Atypical atypical JJ cord-010092-uftc8inx 10886 46 Hemolytic hemolytic JJ cord-010092-uftc8inx 10886 47 uremic uremic JJ cord-010092-uftc8inx 10886 48 syndrome syndrome NN cord-010092-uftc8inx 10886 49 ( ( -LRB- cord-010092-uftc8inx 10886 50 aHUS aHUS NNP cord-010092-uftc8inx 10886 51 ) ) -RRB- cord-010092-uftc8inx 10886 52 . . . cord-010092-uftc8inx 10887 1 Aims aim VBZ cord-010092-uftc8inx 10887 2 : : : cord-010092-uftc8inx 10887 3 To to TO cord-010092-uftc8inx 10887 4 assess assess VB cord-010092-uftc8inx 10887 5 the the DT cord-010092-uftc8inx 10887 6 efficacy efficacy NN cord-010092-uftc8inx 10887 7 and and CC cord-010092-uftc8inx 10887 8 safety safety NN cord-010092-uftc8inx 10887 9 of of IN cord-010092-uftc8inx 10887 10 plasma plasma NN cord-010092-uftc8inx 10887 11 exchange exchange NN cord-010092-uftc8inx 10887 12 in in IN cord-010092-uftc8inx 10887 13 patients patient NNS cord-010092-uftc8inx 10887 14 diagnosed diagnose VBN cord-010092-uftc8inx 10887 15 as as IN cord-010092-uftc8inx 10887 16 having have VBG cord-010092-uftc8inx 10887 17 microangiopathic microangiopathic JJ cord-010092-uftc8inx 10887 18 hemolytic hemolytic JJ cord-010092-uftc8inx 10887 19 anaemias anaemia NNS cord-010092-uftc8inx 10887 20 . . . cord-010092-uftc8inx 10888 1 Methods method NNS cord-010092-uftc8inx 10888 2 : : : cord-010092-uftc8inx 10889 1 A a DT cord-010092-uftc8inx 10889 2 retrospective retrospective JJ cord-010092-uftc8inx 10889 3 analysis analysis NN cord-010092-uftc8inx 10889 4 of of IN cord-010092-uftc8inx 10889 5 all all DT cord-010092-uftc8inx 10889 6 PE PE NNP cord-010092-uftc8inx 10889 7 procedures procedure NNS cord-010092-uftc8inx 10889 8 performed perform VBN cord-010092-uftc8inx 10889 9 in in IN cord-010092-uftc8inx 10889 10 patients patient NNS cord-010092-uftc8inx 10889 11 diagnosed diagnose VBN cord-010092-uftc8inx 10889 12 as as IN cord-010092-uftc8inx 10889 13 having have VBG cord-010092-uftc8inx 10889 14 MAHA MAHA NNP cord-010092-uftc8inx 10889 15 was be VBD cord-010092-uftc8inx 10889 16 done do VBN cord-010092-uftc8inx 10889 17 over over IN cord-010092-uftc8inx 10889 18 a a DT cord-010092-uftc8inx 10889 19 period period NN cord-010092-uftc8inx 10889 20 of of IN cord-010092-uftc8inx 10889 21 9 9 CD cord-010092-uftc8inx 10889 22 years year NNS cord-010092-uftc8inx 10889 23 ( ( -LRB- cord-010092-uftc8inx 10889 24 2007 2007 CD cord-010092-uftc8inx 10889 25 ) ) -RRB- cord-010092-uftc8inx 10890 1 ( ( -LRB- cord-010092-uftc8inx 10890 2 2008 2008 CD cord-010092-uftc8inx 10890 3 ) ) -RRB- cord-010092-uftc8inx 10891 1 ( ( -LRB- cord-010092-uftc8inx 10891 2 2009 2009 CD cord-010092-uftc8inx 10891 3 ) ) -RRB- cord-010092-uftc8inx 10892 1 ( ( -LRB- cord-010092-uftc8inx 10892 2 2010 2010 CD cord-010092-uftc8inx 10892 3 ) ) -RRB- cord-010092-uftc8inx 10893 1 ( ( -LRB- cord-010092-uftc8inx 10893 2 2011 2011 CD cord-010092-uftc8inx 10893 3 ) ) -RRB- cord-010092-uftc8inx 10894 1 ( ( -LRB- cord-010092-uftc8inx 10894 2 2012 2012 CD cord-010092-uftc8inx 10894 3 ) ) -RRB- cord-010092-uftc8inx 10895 1 ( ( -LRB- cord-010092-uftc8inx 10895 2 2013 2013 CD cord-010092-uftc8inx 10895 3 ) ) -RRB- cord-010092-uftc8inx 10896 1 ( ( -LRB- cord-010092-uftc8inx 10896 2 2014 2014 CD cord-010092-uftc8inx 10896 3 ) ) -RRB- cord-010092-uftc8inx 10896 4 ( ( -LRB- cord-010092-uftc8inx 10896 5 2015 2015 CD cord-010092-uftc8inx 10896 6 ) ) -RRB- cord-010092-uftc8inx 10896 7 ( ( -LRB- cord-010092-uftc8inx 10896 8 2016 2016 CD cord-010092-uftc8inx 10896 9 ) ) -RRB- cord-010092-uftc8inx 10896 10 . . . cord-010092-uftc8inx 10897 1 Procedures procedure NNS cord-010092-uftc8inx 10897 2 were be VBD cord-010092-uftc8inx 10897 3 done do VBN cord-010092-uftc8inx 10897 4 on on IN cord-010092-uftc8inx 10897 5 apheretic apheretic JJ cord-010092-uftc8inx 10897 6 device device NN cord-010092-uftc8inx 10897 7 ( ( -LRB- cord-010092-uftc8inx 10897 8 Cobe Cobe NNP cord-010092-uftc8inx 10897 9 Spectra Spectra NNP cord-010092-uftc8inx 10897 10 , , , cord-010092-uftc8inx 10897 11 Terumo Terumo NNP cord-010092-uftc8inx 10897 12 BCT BCT NNP cord-010092-uftc8inx 10897 13 , , , cord-010092-uftc8inx 10897 14 Lakewood Lakewood NNP cord-010092-uftc8inx 10897 15 Co. Co. NNP cord-010092-uftc8inx 10897 16 USA USA NNP cord-010092-uftc8inx 10897 17 ) ) -RRB- cord-010092-uftc8inx 10897 18 . . . cord-010092-uftc8inx 10898 1 Patients patient NNS cord-010092-uftc8inx 10898 2 ' ' POS cord-010092-uftc8inx 10898 3 pre pre JJ cord-010092-uftc8inx 10898 4 and and CC cord-010092-uftc8inx 10898 5 post post VB cord-010092-uftc8inx 10898 6 procedural procedural JJ cord-010092-uftc8inx 10898 7 hematological hematological JJ cord-010092-uftc8inx 10898 8 and and CC cord-010092-uftc8inx 10898 9 renal renal JJ cord-010092-uftc8inx 10898 10 parameters parameter NNS cord-010092-uftc8inx 10898 11 were be VBD cord-010092-uftc8inx 10898 12 analyzed analyze VBN cord-010092-uftc8inx 10898 13 by by IN cord-010092-uftc8inx 10898 14 applying apply VBG cord-010092-uftc8inx 10898 15 paired pair VBN cord-010092-uftc8inx 10898 16 T t NN cord-010092-uftc8inx 10898 17 test test NN cord-010092-uftc8inx 10898 18 . . . cord-010092-uftc8inx 10899 1 Adverse adverse JJ cord-010092-uftc8inx 10899 2 event event NN cord-010092-uftc8inx 10899 3 if if IN cord-010092-uftc8inx 10899 4 any any DT cord-010092-uftc8inx 10899 5 was be VBD cord-010092-uftc8inx 10899 6 recorded record VBN cord-010092-uftc8inx 10899 7 . . . cord-010092-uftc8inx 10900 1 Results result NNS cord-010092-uftc8inx 10900 2 : : : cord-010092-uftc8inx 10900 3 PE PE NNP cord-010092-uftc8inx 10900 4 was be VBD cord-010092-uftc8inx 10900 5 performed perform VBN cord-010092-uftc8inx 10900 6 in in IN cord-010092-uftc8inx 10900 7 46 46 CD cord-010092-uftc8inx 10900 8 patients patient NNS cord-010092-uftc8inx 10900 9 with with IN cord-010092-uftc8inx 10900 10 diagnosis diagnosis NN cord-010092-uftc8inx 10900 11 of of IN cord-010092-uftc8inx 10900 12 MAHA MAHA NNP cord-010092-uftc8inx 10900 13 ( ( -LRB- cord-010092-uftc8inx 10900 14 27-aHUS 27-ahus CD cord-010092-uftc8inx 10900 15 , , , cord-010092-uftc8inx 10900 16 16 16 CD cord-010092-uftc8inx 10900 17 -TTP -ttp SYM cord-010092-uftc8inx 10900 18 , , , cord-010092-uftc8inx 10900 19 1 1 CD cord-010092-uftc8inx 10900 20 each each DT cord-010092-uftc8inx 10900 21 of of IN cord-010092-uftc8inx 10900 22 post post JJ cord-010092-uftc8inx 10900 23 stem stem NN cord-010092-uftc8inx 10900 24 cell cell NN cord-010092-uftc8inx 10900 25 transplantation transplantation NN cord-010092-uftc8inx 10900 26 drug drug NN cord-010092-uftc8inx 10900 27 induced induce VBD cord-010092-uftc8inx 10900 28 thrombotic thrombotic JJ cord-010092-uftc8inx 10900 29 microangiopathy microangiopathy NNP cord-010092-uftc8inx 10900 30 ( ( -LRB- cord-010092-uftc8inx 10900 31 TMA TMA NNP cord-010092-uftc8inx 10900 32 ) ) -RRB- cord-010092-uftc8inx 10900 33 , , , cord-010092-uftc8inx 10900 34 post post NN cord-010092-uftc8inx 10900 35 thyroidectomy thyroidectomy NN cord-010092-uftc8inx 10900 36 TMA TMA NNP cord-010092-uftc8inx 10900 37 and and CC cord-010092-uftc8inx 10900 38 post post JJ cord-010092-uftc8inx 10900 39 - - JJ cord-010092-uftc8inx 10900 40 partum partum JJ cord-010092-uftc8inx 10900 41 TMA TMA NNP cord-010092-uftc8inx 10900 42 ) ) -RRB- cord-010092-uftc8inx 10900 43 . . . cord-010092-uftc8inx 10901 1 The the DT cord-010092-uftc8inx 10901 2 mean mean JJ cord-010092-uftc8inx 10901 3 age age NN cord-010092-uftc8inx 10901 4 of of IN cord-010092-uftc8inx 10901 5 patient patient NN cord-010092-uftc8inx 10901 6 was be VBD cord-010092-uftc8inx 10901 7 19.94 19.94 CD cord-010092-uftc8inx 10901 8 AE AE NNP cord-010092-uftc8inx 10901 9 19.58 19.58 CD cord-010092-uftc8inx 10901 10 years year NNS cord-010092-uftc8inx 10901 11 with with IN cord-010092-uftc8inx 10901 12 M M NNP cord-010092-uftc8inx 10901 13 : : : cord-010092-uftc8inx 10901 14 F f NN cord-010092-uftc8inx 10901 15 as as IN cord-010092-uftc8inx 10901 16 1.5:1 1.5:1 CD cord-010092-uftc8inx 10901 17 . . . cord-010092-uftc8inx 10902 1 Number number NN cord-010092-uftc8inx 10902 2 of of IN cord-010092-uftc8inx 10902 3 procedures procedure NNS cord-010092-uftc8inx 10902 4 per per IN cord-010092-uftc8inx 10902 5 patient patient NN cord-010092-uftc8inx 10902 6 varied varied JJ cord-010092-uftc8inx 10902 7 from from IN cord-010092-uftc8inx 10902 8 1 1 CD cord-010092-uftc8inx 10902 9 to to IN cord-010092-uftc8inx 10902 10 27 27 CD cord-010092-uftc8inx 10902 11 . . . cord-010092-uftc8inx 10903 1 Post Post NNP cord-010092-uftc8inx 10903 2 PE PE NNP cord-010092-uftc8inx 10903 3 recovery recovery NN cord-010092-uftc8inx 10903 4 was be VBD cord-010092-uftc8inx 10903 5 observed observe VBN cord-010092-uftc8inx 10903 6 within within IN cord-010092-uftc8inx 10903 7 10 10 CD cord-010092-uftc8inx 10903 8 - - SYM cord-010092-uftc8inx 10903 9 14 14 CD cord-010092-uftc8inx 10903 10 days day NNS cord-010092-uftc8inx 10903 11 with with IN cord-010092-uftc8inx 10903 12 statistically statistically RB cord-010092-uftc8inx 10903 13 significant significant JJ cord-010092-uftc8inx 10903 14 increase increase NN cord-010092-uftc8inx 10903 15 in in IN cord-010092-uftc8inx 10903 16 mean mean JJ cord-010092-uftc8inx 10903 17 platelet platelet NN cord-010092-uftc8inx 10903 18 count count NN cord-010092-uftc8inx 10903 19 from from IN cord-010092-uftc8inx 10903 20 40.05 40.05 CD cord-010092-uftc8inx 10903 21 AE AE NNP cord-010092-uftc8inx 10903 22 5.9 5.9 CD cord-010092-uftc8inx 10903 23 to to IN cord-010092-uftc8inx 10903 24 82.11 82.11 CD cord-010092-uftc8inx 10903 25 AE AE NNP cord-010092-uftc8inx 10903 26 12.10 12.10 CD cord-010092-uftc8inx 10903 27 9 9 CD cord-010092-uftc8inx 10903 28 10 10 CD cord-010092-uftc8inx 10903 29 9 9 CD cord-010092-uftc8inx 10903 30 /L /L . cord-010092-uftc8inx 10903 31 ( ( -LRB- cord-010092-uftc8inx 10903 32 P p NN cord-010092-uftc8inx 10903 33 = = SYM cord-010092-uftc8inx 10903 34 0.000 0.000 CD cord-010092-uftc8inx 10903 35 ) ) -RRB- cord-010092-uftc8inx 10903 36 and and CC cord-010092-uftc8inx 10903 37 significant significant JJ cord-010092-uftc8inx 10903 38 decline decline NN cord-010092-uftc8inx 10903 39 in in IN cord-010092-uftc8inx 10903 40 mean mean JJ cord-010092-uftc8inx 10903 41 lactate lactate NN cord-010092-uftc8inx 10903 42 dehydrogenase dehydrogenase NN cord-010092-uftc8inx 10903 43 level level NN cord-010092-uftc8inx 10903 44 from from IN cord-010092-uftc8inx 10903 45 48.91 48.91 CD cord-010092-uftc8inx 10903 46 AE AE NNP cord-010092-uftc8inx 10903 47 34.73 34.73 CD cord-010092-uftc8inx 10903 48 to to IN cord-010092-uftc8inx 10903 49 10.98 10.98 CD cord-010092-uftc8inx 10903 50 AE AE NNP cord-010092-uftc8inx 10903 51 6.49 6.49 CD cord-010092-uftc8inx 10903 52 lkat lkat NN cord-010092-uftc8inx 10903 53 / / SYM cord-010092-uftc8inx 10903 54 L l NN cord-010092-uftc8inx 10903 55 ( ( -LRB- cord-010092-uftc8inx 10903 56 P p NN cord-010092-uftc8inx 10903 57 = = SYM cord-010092-uftc8inx 10903 58 0.000 0.000 CD cord-010092-uftc8inx 10903 59 ) ) -RRB- cord-010092-uftc8inx 10903 60 . . . cord-010092-uftc8inx 10904 1 There there EX cord-010092-uftc8inx 10904 2 was be VBD cord-010092-uftc8inx 10904 3 also also RB cord-010092-uftc8inx 10904 4 significant significant JJ cord-010092-uftc8inx 10904 5 decline decline NN cord-010092-uftc8inx 10904 6 in in IN cord-010092-uftc8inx 10904 7 mean mean JJ cord-010092-uftc8inx 10904 8 percentage percentage NN cord-010092-uftc8inx 10904 9 of of IN cord-010092-uftc8inx 10904 10 schistocytes schistocyte NNS cord-010092-uftc8inx 10904 11 in in IN cord-010092-uftc8inx 10904 12 peripheral peripheral JJ cord-010092-uftc8inx 10904 13 smear smear NN cord-010092-uftc8inx 10904 14 from from IN cord-010092-uftc8inx 10904 15 5.44 5.44 CD cord-010092-uftc8inx 10904 16 AE AE NNP cord-010092-uftc8inx 10904 17 3.96 3.96 CD cord-010092-uftc8inx 10904 18 % % NN cord-010092-uftc8inx 10904 19 to to IN cord-010092-uftc8inx 10904 20 0.56 0.56 CD cord-010092-uftc8inx 10904 21 AE AE NNP cord-010092-uftc8inx 10904 22 0.89 0.89 CD cord-010092-uftc8inx 10904 23 % % NN cord-010092-uftc8inx 10904 24 ( ( -LRB- cord-010092-uftc8inx 10904 25 P p NN cord-010092-uftc8inx 10904 26 = = SYM cord-010092-uftc8inx 10904 27 0.000 0.000 CD cord-010092-uftc8inx 10904 28 ) ) -RRB- cord-010092-uftc8inx 10904 29 . . . cord-010092-uftc8inx 10905 1 The the DT cord-010092-uftc8inx 10905 2 mean mean JJ cord-010092-uftc8inx 10905 3 serum serum NN cord-010092-uftc8inx 10905 4 urea urea NN cord-010092-uftc8inx 10905 5 changed change VBD cord-010092-uftc8inx 10905 6 from from IN cord-010092-uftc8inx 10905 7 48.88 48.88 CD cord-010092-uftc8inx 10905 8 AE AE NNP cord-010092-uftc8inx 10905 9 24.56 24.56 CD cord-010092-uftc8inx 10905 10 to to IN cord-010092-uftc8inx 10905 11 24.50 24.50 CD cord-010092-uftc8inx 10905 12 AE AE NNP cord-010092-uftc8inx 10905 13 17.78 17.78 CD cord-010092-uftc8inx 10905 14 mmol mmol NNP cord-010092-uftc8inx 10905 15 / / SYM cord-010092-uftc8inx 10905 16 L l NN cord-010092-uftc8inx 10905 17 and and CC cord-010092-uftc8inx 10905 18 creatinine creatinine NN cord-010092-uftc8inx 10905 19 from from IN cord-010092-uftc8inx 10905 20 266.11 266.11 CD cord-010092-uftc8inx 10905 21 AE AE NNP cord-010092-uftc8inx 10905 22 142.59 142.59 CD cord-010092-uftc8inx 10905 23 to to IN cord-010092-uftc8inx 10905 24 173.09 173.09 CD cord-010092-uftc8inx 10905 25 AE AE NNP cord-010092-uftc8inx 10905 26 127.34 127.34 CD cord-010092-uftc8inx 10905 27 lmol lmol NNP cord-010092-uftc8inx 10905 28 / / SYM cord-010092-uftc8inx 10905 29 L l NN cord-010092-uftc8inx 10905 30 ( ( -LRB- cord-010092-uftc8inx 10905 31 P p NN cord-010092-uftc8inx 10905 32 = = SYM cord-010092-uftc8inx 10905 33 0.000 0.000 CD cord-010092-uftc8inx 10905 34 and and CC cord-010092-uftc8inx 10905 35 0.001 0.001 CD cord-010092-uftc8inx 10905 36 respectively respectively RB cord-010092-uftc8inx 10905 37 ) ) -RRB- cord-010092-uftc8inx 10905 38 with with IN cord-010092-uftc8inx 10905 39 significant significant JJ cord-010092-uftc8inx 10905 40 increase increase NN cord-010092-uftc8inx 10905 41 in in IN cord-010092-uftc8inx 10905 42 urine urine NN cord-010092-uftc8inx 10905 43 output output NN cord-010092-uftc8inx 10905 44 from from IN cord-010092-uftc8inx 10905 45 0.71 0.71 CD cord-010092-uftc8inx 10905 46 AE AE NNP cord-010092-uftc8inx 10905 47 0.53 0.53 CD cord-010092-uftc8inx 10905 48 to to IN cord-010092-uftc8inx 10905 49 1.06 1.06 CD cord-010092-uftc8inx 10905 50 AE AE NNP cord-010092-uftc8inx 10906 1 0.33 0.33 CD cord-010092-uftc8inx 10906 2 ml ml NNP cord-010092-uftc8inx 10906 3 / / SYM cord-010092-uftc8inx 10906 4 kg kg NNP cord-010092-uftc8inx 10906 5 / / SYM cord-010092-uftc8inx 10906 6 h h NN cord-010092-uftc8inx 10906 7 ( ( -LRB- cord-010092-uftc8inx 10906 8 P p NN cord-010092-uftc8inx 10906 9 = = SYM cord-010092-uftc8inx 10906 10 0.000 0.000 CD cord-010092-uftc8inx 10906 11 ) ) -RRB- cord-010092-uftc8inx 10906 12 . . . cord-010092-uftc8inx 10907 1 Adverse adverse JJ cord-010092-uftc8inx 10907 2 events event NNS cord-010092-uftc8inx 10907 3 were be VBD cord-010092-uftc8inx 10907 4 observed observe VBN cord-010092-uftc8inx 10907 5 in in IN cord-010092-uftc8inx 10907 6 10 10 CD cord-010092-uftc8inx 10907 7 patients patient NNS cord-010092-uftc8inx 10907 8 ( ( -LRB- cord-010092-uftc8inx 10907 9 21 21 CD cord-010092-uftc8inx 10907 10 % % NN cord-010092-uftc8inx 10907 11 ) ) -RRB- cord-010092-uftc8inx 10907 12 , , , cord-010092-uftc8inx 10907 13 allergic allergic JJ cord-010092-uftc8inx 10907 14 reaction reaction NN cord-010092-uftc8inx 10907 15 to to IN cord-010092-uftc8inx 10907 16 replacement replacement NN cord-010092-uftc8inx 10907 17 fluid fluid NN cord-010092-uftc8inx 10907 18 ( ( -LRB- cord-010092-uftc8inx 10907 19 n n NN cord-010092-uftc8inx 10907 20 = = SYM cord-010092-uftc8inx 10907 21 6 6 CD cord-010092-uftc8inx 10907 22 ) ) -RRB- cord-010092-uftc8inx 10907 23 being be VBG cord-010092-uftc8inx 10907 24 the the DT cord-010092-uftc8inx 10907 25 commonest common JJS cord-010092-uftc8inx 10907 26 followed follow VBN cord-010092-uftc8inx 10907 27 by by IN cord-010092-uftc8inx 10907 28 hypotension hypotension NN cord-010092-uftc8inx 10907 29 ( ( -LRB- cord-010092-uftc8inx 10907 30 n n NN cord-010092-uftc8inx 10907 31 = = SYM cord-010092-uftc8inx 10907 32 2 2 CD cord-010092-uftc8inx 10907 33 ) ) -RRB- cord-010092-uftc8inx 10907 34 , , , cord-010092-uftc8inx 10907 35 rigors rigor NNS cord-010092-uftc8inx 10907 36 and and CC cord-010092-uftc8inx 10907 37 chills chill NNS cord-010092-uftc8inx 10907 38 ( ( -LRB- cord-010092-uftc8inx 10907 39 n n NN cord-010092-uftc8inx 10907 40 = = SYM cord-010092-uftc8inx 10907 41 2 2 CD cord-010092-uftc8inx 10907 42 ) ) -RRB- cord-010092-uftc8inx 10907 43 . . . cord-010092-uftc8inx 10908 1 Overall overall JJ cord-010092-uftc8inx 10908 2 survival survival NN cord-010092-uftc8inx 10908 3 rate rate NN cord-010092-uftc8inx 10908 4 at at IN cord-010092-uftc8inx 10908 5 6 6 CD cord-010092-uftc8inx 10908 6 months month NNS cord-010092-uftc8inx 10908 7 was be VBD cord-010092-uftc8inx 10908 8 89 89 CD cord-010092-uftc8inx 10908 9 % % NN cord-010092-uftc8inx 10908 10 . . . cord-010092-uftc8inx 10909 1 Summary Summary NNP cord-010092-uftc8inx 10909 2 / / SYM cord-010092-uftc8inx 10909 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 10909 4 : : : cord-010092-uftc8inx 10910 1 PE PE NNP cord-010092-uftc8inx 10910 2 had have VBD cord-010092-uftc8inx 10910 3 proven prove VBN cord-010092-uftc8inx 10910 4 its -PRON- PRP$ cord-010092-uftc8inx 10910 5 safety safety NN cord-010092-uftc8inx 10910 6 and and CC cord-010092-uftc8inx 10910 7 usefulness usefulness NN cord-010092-uftc8inx 10910 8 as as IN cord-010092-uftc8inx 10910 9 life life NN cord-010092-uftc8inx 10910 10 - - HYPH cord-010092-uftc8inx 10910 11 saving save VBG cord-010092-uftc8inx 10910 12 first first JJ cord-010092-uftc8inx 10910 13 line line NN cord-010092-uftc8inx 10910 14 treatment treatment NN cord-010092-uftc8inx 10910 15 modality modality NN cord-010092-uftc8inx 10910 16 in in IN cord-010092-uftc8inx 10910 17 MAHA MAHA NNP cord-010092-uftc8inx 10910 18 . . . cord-010092-uftc8inx 10911 1 Prompt prompt JJ cord-010092-uftc8inx 10911 2 and and CC cord-010092-uftc8inx 10911 3 aggressive aggressive JJ cord-010092-uftc8inx 10911 4 treatment treatment NN cord-010092-uftc8inx 10911 5 helps help VBZ cord-010092-uftc8inx 10911 6 in in IN cord-010092-uftc8inx 10911 7 achieving achieve VBG cord-010092-uftc8inx 10911 8 early early JJ cord-010092-uftc8inx 10911 9 and and CC cord-010092-uftc8inx 10911 10 complete complete JJ cord-010092-uftc8inx 10911 11 remission remission NN cord-010092-uftc8inx 10911 12 in in IN cord-010092-uftc8inx 10911 13 these these DT cord-010092-uftc8inx 10911 14 patients patient NNS cord-010092-uftc8inx 10911 15 . . . cord-010092-uftc8inx 10912 1 Background background NN cord-010092-uftc8inx 10912 2 : : : cord-010092-uftc8inx 10913 1 Neuromyelitis Neuromyelitis NNP cord-010092-uftc8inx 10913 2 optica optica NN cord-010092-uftc8inx 10913 3 ( ( -LRB- cord-010092-uftc8inx 10913 4 NMO NMO NNP cord-010092-uftc8inx 10913 5 ) ) -RRB- cord-010092-uftc8inx 10913 6 also also RB cord-010092-uftc8inx 10913 7 known know VBN cord-010092-uftc8inx 10913 8 as as IN cord-010092-uftc8inx 10913 9 Devic Devic NNP cord-010092-uftc8inx 10913 10 's 's POS cord-010092-uftc8inx 10913 11 disease disease NN cord-010092-uftc8inx 10913 12 or or CC cord-010092-uftc8inx 10913 13 Devic Devic NNP cord-010092-uftc8inx 10913 14 's 's POS cord-010092-uftc8inx 10913 15 syndrome syndrome NN cord-010092-uftc8inx 10913 16 is be VBZ cord-010092-uftc8inx 10913 17 a a DT cord-010092-uftc8inx 10913 18 rare rare JJ cord-010092-uftc8inx 10913 19 demyelinating demyelinating JJ cord-010092-uftc8inx 10913 20 disease disease NN cord-010092-uftc8inx 10913 21 of of IN cord-010092-uftc8inx 10913 22 the the DT cord-010092-uftc8inx 10913 23 central central JJ cord-010092-uftc8inx 10913 24 nervous nervous JJ cord-010092-uftc8inx 10913 25 system system NN cord-010092-uftc8inx 10913 26 that that WDT cord-010092-uftc8inx 10913 27 most most RBS cord-010092-uftc8inx 10913 28 often often RB cord-010092-uftc8inx 10913 29 results result VBZ cord-010092-uftc8inx 10913 30 in in IN cord-010092-uftc8inx 10913 31 selective selective JJ cord-010092-uftc8inx 10913 32 involvement involvement NN cord-010092-uftc8inx 10913 33 of of IN cord-010092-uftc8inx 10913 34 the the DT cord-010092-uftc8inx 10913 35 optic optic JJ cord-010092-uftc8inx 10913 36 nerves nerve NNS cord-010092-uftc8inx 10913 37 ( ( -LRB- cord-010092-uftc8inx 10913 38 optic optic JJ cord-010092-uftc8inx 10913 39 neuritis neuritis NN cord-010092-uftc8inx 10913 40 ) ) -RRB- cord-010092-uftc8inx 10913 41 and and CC cord-010092-uftc8inx 10913 42 spinal spinal JJ cord-010092-uftc8inx 10913 43 cord cord NN cord-010092-uftc8inx 10913 44 ( ( -LRB- cord-010092-uftc8inx 10913 45 myelitis)and myelitis)and NNP cord-010092-uftc8inx 10913 46 has have VBZ cord-010092-uftc8inx 10913 47 female female JJ cord-010092-uftc8inx 10913 48 preponderance preponderance NN cord-010092-uftc8inx 10913 49 . . . cord-010092-uftc8inx 10914 1 Neuromyelitis Neuromyelitis NNP cord-010092-uftc8inx 10914 2 optica optica NN cord-010092-uftc8inx 10914 3 ( ( -LRB- cord-010092-uftc8inx 10914 4 NMO NMO NNP cord-010092-uftc8inx 10914 5 ) ) -RRB- cord-010092-uftc8inx 10914 6 attacks attack NNS cord-010092-uftc8inx 10914 7 are be VBP cord-010092-uftc8inx 10914 8 poorly poorly RB cord-010092-uftc8inx 10914 9 controlled control VBN cord-010092-uftc8inx 10914 10 by by IN cord-010092-uftc8inx 10914 11 steroids steroid NNS cord-010092-uftc8inx 10914 12 and and CC cord-010092-uftc8inx 10914 13 evolve evolve VB cord-010092-uftc8inx 10914 14 in in IN cord-010092-uftc8inx 10914 15 stepwise stepwise JJ cord-010092-uftc8inx 10914 16 neurological neurological JJ cord-010092-uftc8inx 10914 17 impairments impairment NNS cord-010092-uftc8inx 10914 18 . . . cord-010092-uftc8inx 10915 1 Assuming assume VBG cord-010092-uftc8inx 10915 2 the the DT cord-010092-uftc8inx 10915 3 strong strong JJ cord-010092-uftc8inx 10915 4 humoral humoral JJ cord-010092-uftc8inx 10915 5 response response NN cord-010092-uftc8inx 10915 6 underlying underlie VBG cord-010092-uftc8inx 10915 7 NMO NMO NNP cord-010092-uftc8inx 10915 8 attacks attack NNS cord-010092-uftc8inx 10915 9 , , , cord-010092-uftc8inx 10915 10 Therapeutic Therapeutic NNP cord-010092-uftc8inx 10915 11 Plasma Plasma NNP cord-010092-uftc8inx 10915 12 Exchange Exchange NNP cord-010092-uftc8inx 10915 13 is be VBZ cord-010092-uftc8inx 10915 14 an an DT cord-010092-uftc8inx 10915 15 appropriate appropriate JJ cord-010092-uftc8inx 10915 16 technique technique NN cord-010092-uftc8inx 10915 17 in in IN cord-010092-uftc8inx 10915 18 severe severe JJ cord-010092-uftc8inx 10915 19 NMO NMO NNP cord-010092-uftc8inx 10915 20 attacks attack NNS cord-010092-uftc8inx 10915 21 . . . cord-010092-uftc8inx 10916 1 Aims aim VBZ cord-010092-uftc8inx 10916 2 : : : cord-010092-uftc8inx 10916 3 To to TO cord-010092-uftc8inx 10916 4 study study VB cord-010092-uftc8inx 10916 5 the the DT cord-010092-uftc8inx 10916 6 effect effect NN cord-010092-uftc8inx 10916 7 of of IN cord-010092-uftc8inx 10916 8 TPE TPE NNP cord-010092-uftc8inx 10916 9 in in IN cord-010092-uftc8inx 10916 10 Neuromyelitis Neuromyelitis NNP cord-010092-uftc8inx 10916 11 Optica Optica NNP cord-010092-uftc8inx 10916 12 . . . cord-010092-uftc8inx 10917 1 Methods method NNS cord-010092-uftc8inx 10917 2 : : : cord-010092-uftc8inx 10918 1 A a DT cord-010092-uftc8inx 10918 2 17 17 CD cord-010092-uftc8inx 10918 3 year year NN cord-010092-uftc8inx 10918 4 old old JJ cord-010092-uftc8inx 10918 5 Female Female NNP cord-010092-uftc8inx 10918 6 in in IN cord-010092-uftc8inx 10918 7 the the DT cord-010092-uftc8inx 10918 8 Medicine Medicine NNP cord-010092-uftc8inx 10918 9 department department NN cord-010092-uftc8inx 10918 10 , , , cord-010092-uftc8inx 10918 11 Civil civil JJ cord-010092-uftc8inx 10918 12 hospital hospital NN cord-010092-uftc8inx 10918 13 , , , cord-010092-uftc8inx 10918 14 Ahmedabad Ahmedabad NNP cord-010092-uftc8inx 10918 15 admitted admit VBD cord-010092-uftc8inx 10918 16 with with IN cord-010092-uftc8inx 10918 17 chief chief JJ cord-010092-uftc8inx 10918 18 complains complain NNS cord-010092-uftc8inx 10918 19 of of IN cord-010092-uftc8inx 10918 20 weakness weakness NN cord-010092-uftc8inx 10918 21 and and CC cord-010092-uftc8inx 10918 22 numbness numbness NN cord-010092-uftc8inx 10918 23 in in IN cord-010092-uftc8inx 10918 24 the the DT cord-010092-uftc8inx 10918 25 arms arm NNS cord-010092-uftc8inx 10918 26 and and CC cord-010092-uftc8inx 10918 27 legs leg NNS cord-010092-uftc8inx 10918 28 , , , cord-010092-uftc8inx 10918 29 blurred blurred JJ cord-010092-uftc8inx 10918 30 vision vision NN cord-010092-uftc8inx 10918 31 , , , cord-010092-uftc8inx 10918 32 reduced reduce VBN cord-010092-uftc8inx 10918 33 sensation sensation NN cord-010092-uftc8inx 10918 34 , , , cord-010092-uftc8inx 10918 35 difficulty difficulty NN cord-010092-uftc8inx 10918 36 in in IN cord-010092-uftc8inx 10918 37 controlling control VBG cord-010092-uftc8inx 10918 38 bladder bladder NN cord-010092-uftc8inx 10918 39 and and CC cord-010092-uftc8inx 10918 40 bowels bowel NNS cord-010092-uftc8inx 10918 41 , , , cord-010092-uftc8inx 10918 42 uncontrollable uncontrollable JJ cord-010092-uftc8inx 10918 43 vomiting vomiting NN cord-010092-uftc8inx 10918 44 and and CC cord-010092-uftc8inx 10918 45 hiccups hiccup NNS cord-010092-uftc8inx 10918 46 since since IN cord-010092-uftc8inx 10918 47 2 2 CD cord-010092-uftc8inx 10918 48 - - SYM cord-010092-uftc8inx 10918 49 3 3 CD cord-010092-uftc8inx 10918 50 days day NNS cord-010092-uftc8inx 10918 51 in in IN cord-010092-uftc8inx 10918 52 the the DT cord-010092-uftc8inx 10918 53 medicine medicine NN cord-010092-uftc8inx 10918 54 department department NN cord-010092-uftc8inx 10918 55 , , , cord-010092-uftc8inx 10918 56 Civil civil JJ cord-010092-uftc8inx 10918 57 hospital hospital NN cord-010092-uftc8inx 10918 58 , , , cord-010092-uftc8inx 10918 59 Ahmedabad Ahmedabad NNP cord-010092-uftc8inx 10918 60 . . . cord-010092-uftc8inx 10919 1 Attacks attack NNS cord-010092-uftc8inx 10919 2 were be VBD cord-010092-uftc8inx 10919 3 treated treat VBN cord-010092-uftc8inx 10919 4 with with IN cord-010092-uftc8inx 10919 5 short short JJ cord-010092-uftc8inx 10919 6 courses course NNS cord-010092-uftc8inx 10919 7 of of IN cord-010092-uftc8inx 10919 8 high high JJ cord-010092-uftc8inx 10919 9 doses dose NNS cord-010092-uftc8inx 10919 10 of of IN cord-010092-uftc8inx 10919 11 intravenous intravenous JJ cord-010092-uftc8inx 10919 12 corticosteroid corticosteroid NN cord-010092-uftc8inx 10919 13 -Methylprednisolone -Methylprednisolone NNP cord-010092-uftc8inx 10919 14 Intravenous Intravenous NNP cord-010092-uftc8inx 10919 15 . . . cord-010092-uftc8inx 10920 1 But but CC cord-010092-uftc8inx 10920 2 there there EX cord-010092-uftc8inx 10920 3 was be VBD cord-010092-uftc8inx 10920 4 no no DT cord-010092-uftc8inx 10920 5 clinical clinical JJ cord-010092-uftc8inx 10920 6 improvement improvement NN cord-010092-uftc8inx 10920 7 . . . cord-010092-uftc8inx 10921 1 Results result NNS cord-010092-uftc8inx 10921 2 : : : cord-010092-uftc8inx 10922 1 Clinician clinician NN cord-010092-uftc8inx 10922 2 advised advise VBD cord-010092-uftc8inx 10922 3 for for IN cord-010092-uftc8inx 10922 4 the the DT cord-010092-uftc8inx 10922 5 trial trial NN cord-010092-uftc8inx 10922 6 of of IN cord-010092-uftc8inx 10922 7 TPE TPE NNP cord-010092-uftc8inx 10922 8 in in IN cord-010092-uftc8inx 10922 9 this this DT cord-010092-uftc8inx 10922 10 patient patient NN cord-010092-uftc8inx 10922 11 . . . cord-010092-uftc8inx 10923 1 The the DT cord-010092-uftc8inx 10923 2 procedure procedure NN cord-010092-uftc8inx 10923 3 was be VBD cord-010092-uftc8inx 10923 4 performed perform VBN cord-010092-uftc8inx 10923 5 by by IN cord-010092-uftc8inx 10923 6 automated automate VBN cord-010092-uftc8inx 10923 7 device device NN cord-010092-uftc8inx 10923 8 with with IN cord-010092-uftc8inx 10923 9 continuous continuous JJ cord-010092-uftc8inx 10923 10 flow flow NN cord-010092-uftc8inx 10923 11 centrifuge centrifuge NN cord-010092-uftc8inx 10923 12 machine machine NN cord-010092-uftc8inx 10923 13 Fresenius Fresenius NNP cord-010092-uftc8inx 10923 14 Kabi Kabi NNP cord-010092-uftc8inx 10923 15 - - HYPH cord-010092-uftc8inx 10923 16 COM.TEC COM.TEC NNP cord-010092-uftc8inx 10923 17 using use VBG cord-010092-uftc8inx 10923 18 double double JJ cord-010092-uftc8inx 10923 19 lumen lumen JJ cord-010092-uftc8inx 10923 20 femoral femoral JJ cord-010092-uftc8inx 10923 21 catheter catheter NN cord-010092-uftc8inx 10923 22 . . . cord-010092-uftc8inx 10924 1 After after IN cord-010092-uftc8inx 10924 2 obtaining obtain VBG cord-010092-uftc8inx 10924 3 informed informed JJ cord-010092-uftc8inx 10924 4 consent consent NN cord-010092-uftc8inx 10924 5 from from IN cord-010092-uftc8inx 10924 6 the the DT cord-010092-uftc8inx 10924 7 relative relative NN cord-010092-uftc8inx 10924 8 of of IN cord-010092-uftc8inx 10924 9 the the DT cord-010092-uftc8inx 10924 10 patient patient NN cord-010092-uftc8inx 10924 11 , , , cord-010092-uftc8inx 10924 12 6 6 CD cord-010092-uftc8inx 10924 13 cycles cycle NNS cord-010092-uftc8inx 10924 14 of of IN cord-010092-uftc8inx 10924 15 TPE TPE NNP cord-010092-uftc8inx 10924 16 were be VBD cord-010092-uftc8inx 10924 17 performed perform VBN cord-010092-uftc8inx 10924 18 on on IN cord-010092-uftc8inx 10924 19 daily daily JJ cord-010092-uftc8inx 10924 20 basis basis NN cord-010092-uftc8inx 10924 21 . . . cord-010092-uftc8inx 10925 1 After after IN cord-010092-uftc8inx 10925 2 6 6 CD cord-010092-uftc8inx 10925 3 cycles cycle NNS cord-010092-uftc8inx 10925 4 , , , cord-010092-uftc8inx 10925 5 both both CC cord-010092-uftc8inx 10925 6 subjective subjective JJ cord-010092-uftc8inx 10925 7 and and CC cord-010092-uftc8inx 10925 8 objective objective JJ cord-010092-uftc8inx 10925 9 clinical clinical JJ cord-010092-uftc8inx 10925 10 response response NN cord-010092-uftc8inx 10925 11 to to IN cord-010092-uftc8inx 10925 12 TPE TPE NNP cord-010092-uftc8inx 10925 13 was be VBD cord-010092-uftc8inx 10925 14 estimated estimate VBN cord-010092-uftc8inx 10925 15 by by IN cord-010092-uftc8inx 10925 16 three three CD cord-010092-uftc8inx 10925 17 different different JJ cord-010092-uftc8inx 10925 18 sources source NNS cord-010092-uftc8inx 10925 19 ( ( -LRB- cord-010092-uftc8inx 10925 20 the the DT cord-010092-uftc8inx 10925 21 patient patient NN cord-010092-uftc8inx 10925 22 , , , cord-010092-uftc8inx 10925 23 a a DT cord-010092-uftc8inx 10925 24 Transfusion Transfusion NNP cord-010092-uftc8inx 10925 25 Medicine Medicine NNP cord-010092-uftc8inx 10925 26 Physician Physician NNP cord-010092-uftc8inx 10925 27 , , , cord-010092-uftc8inx 10925 28 and and CC cord-010092-uftc8inx 10925 29 the the DT cord-010092-uftc8inx 10925 30 treating treat VBG cord-010092-uftc8inx 10925 31 Neurologist Neurologist NNP cord-010092-uftc8inx 10925 32 ) ) -RRB- cord-010092-uftc8inx 10925 33 . . . cord-010092-uftc8inx 10926 1 [ [ -LRB- cord-010092-uftc8inx 10926 2 1 1 CD cord-010092-uftc8inx 10926 3 ] ] -RRB- cord-010092-uftc8inx 10926 4 For for IN cord-010092-uftc8inx 10926 5 Motor Motor NNP cord-010092-uftc8inx 10926 6 Performance Performance NNP cord-010092-uftc8inx 10926 7 , , , cord-010092-uftc8inx 10926 8 patient patient NN cord-010092-uftc8inx 10926 9 was be VBD cord-010092-uftc8inx 10926 10 assessed assess VBN cord-010092-uftc8inx 10926 11 on on IN cord-010092-uftc8inx 10926 12 a a DT cord-010092-uftc8inx 10926 13 disability disability NN cord-010092-uftc8inx 10926 14 scale scale NN cord-010092-uftc8inx 10926 15 ( ( -LRB- cord-010092-uftc8inx 10926 16 0 0 NFP cord-010092-uftc8inx 10926 17 = = SYM cord-010092-uftc8inx 10926 18 healthy healthy JJ cord-010092-uftc8inx 10926 19 ; ; : cord-010092-uftc8inx 10926 20 1 1 CD cord-010092-uftc8inx 10926 21 = = SYM cord-010092-uftc8inx 10926 22 minor minor JJ cord-010092-uftc8inx 10926 23 symptoms symptom NNS cord-010092-uftc8inx 10926 24 ; ; : cord-010092-uftc8inx 10926 25 2 2 LS cord-010092-uftc8inx 10926 26 = = SYM cord-010092-uftc8inx 10926 27 able able JJ cord-010092-uftc8inx 10926 28 to to TO cord-010092-uftc8inx 10926 29 walk walk VB cord-010092-uftc8inx 10926 30 5 5 CD cord-010092-uftc8inx 10926 31 meters meter NNS cord-010092-uftc8inx 10926 32 without without IN cord-010092-uftc8inx 10926 33 support support NN cord-010092-uftc8inx 10926 34 ; ; : cord-010092-uftc8inx 10926 35 3 3 LS cord-010092-uftc8inx 10926 36 = = SYM cord-010092-uftc8inx 10926 37 able able JJ cord-010092-uftc8inx 10926 38 to to TO cord-010092-uftc8inx 10926 39 walk walk VB cord-010092-uftc8inx 10926 40 5 5 CD cord-010092-uftc8inx 10926 41 meters meter NNS cord-010092-uftc8inx 10926 42 with with IN cord-010092-uftc8inx 10926 43 support support NN cord-010092-uftc8inx 10926 44 ; ; : cord-010092-uftc8inx 10926 45 4 4 CD cord-010092-uftc8inx 10926 46 = = SYM cord-010092-uftc8inx 10926 47 confined confine VBN cord-010092-uftc8inx 10926 48 to to IN cord-010092-uftc8inx 10926 49 bed bed NN cord-010092-uftc8inx 10926 50 or or CC cord-010092-uftc8inx 10926 51 wheelchair wheelchair NN cord-010092-uftc8inx 10926 52 ; ; : cord-010092-uftc8inx 10926 53 5 5 LS cord-010092-uftc8inx 10926 54 = = SYM cord-010092-uftc8inx 10926 55 requiring require VBG cord-010092-uftc8inx 10926 56 assisted assist VBN cord-010092-uftc8inx 10926 57 ventilation ventilation NN cord-010092-uftc8inx 10926 58 ; ; : cord-010092-uftc8inx 10926 59 6 6 CD cord-010092-uftc8inx 10926 60 = = SYM cord-010092-uftc8inx 10926 61 dead).Patient dead).patient NN cord-010092-uftc8inx 10926 62 's 's POS cord-010092-uftc8inx 10926 63 motor motor NN cord-010092-uftc8inx 10926 64 performance performance NN cord-010092-uftc8inx 10926 65 was be VBD cord-010092-uftc8inx 10926 66 increased increase VBN cord-010092-uftc8inx 10926 67 to to IN cord-010092-uftc8inx 10926 68 Scale scale NN cord-010092-uftc8inx 10926 69 1(Upper 1(upper CD cord-010092-uftc8inx 10926 70 limb limb NN cord-010092-uftc8inx 10926 71 ) ) -RRB- cord-010092-uftc8inx 10926 72 and and CC cord-010092-uftc8inx 10926 73 2(Lower 2(lower CD cord-010092-uftc8inx 10926 74 Limb limb NN cord-010092-uftc8inx 10926 75 ) ) -RRB- cord-010092-uftc8inx 10926 76 from from IN cord-010092-uftc8inx 10926 77 Scale scale NN cord-010092-uftc8inx 10926 78 5 5 CD cord-010092-uftc8inx 10926 79 , , , cord-010092-uftc8inx 10926 80 deep deep JJ cord-010092-uftc8inx 10926 81 tendon tendon NN cord-010092-uftc8inx 10926 82 reflexes reflex NNS cord-010092-uftc8inx 10926 83 were be VBD cord-010092-uftc8inx 10926 84 normal normal JJ cord-010092-uftc8inx 10926 85 . . . cord-010092-uftc8inx 10927 1 Visual visual JJ cord-010092-uftc8inx 10927 2 function function NN cord-010092-uftc8inx 10927 3 began begin VBD cord-010092-uftc8inx 10927 4 to to TO cord-010092-uftc8inx 10927 5 improve improve VB cord-010092-uftc8inx 10927 6 1 1 CD cord-010092-uftc8inx 10927 7 week week NN cord-010092-uftc8inx 10927 8 after after IN cord-010092-uftc8inx 10927 9 the the DT cord-010092-uftc8inx 10927 10 treatment treatment NN cord-010092-uftc8inx 10927 11 . . . cord-010092-uftc8inx 10928 1 Visual visual JJ cord-010092-uftc8inx 10928 2 acuity acuity NN cord-010092-uftc8inx 10928 3 was be VBD cord-010092-uftc8inx 10928 4 6/6 6/6 CD cord-010092-uftc8inx 10928 5 after after IN cord-010092-uftc8inx 10928 6 4 4 CD cord-010092-uftc8inx 10928 7 weeks week NNS cord-010092-uftc8inx 10928 8 . . . cord-010092-uftc8inx 10929 1 Summary Summary NNP cord-010092-uftc8inx 10929 2 / / SYM cord-010092-uftc8inx 10929 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 10929 4 : : : cord-010092-uftc8inx 10930 1 Assuming assume VBG cord-010092-uftc8inx 10930 2 the the DT cord-010092-uftc8inx 10930 3 strong strong JJ cord-010092-uftc8inx 10930 4 humoral humoral JJ cord-010092-uftc8inx 10930 5 response response NN cord-010092-uftc8inx 10930 6 underlying underlie VBG cord-010092-uftc8inx 10930 7 NMO NMO NNP cord-010092-uftc8inx 10930 8 attacks attack NNS cord-010092-uftc8inx 10930 9 , , , cord-010092-uftc8inx 10930 10 Therapeutic Therapeutic NNP cord-010092-uftc8inx 10930 11 Plasma Plasma NNP cord-010092-uftc8inx 10930 12 Exchange Exchange NNP cord-010092-uftc8inx 10930 13 is be VBZ cord-010092-uftc8inx 10930 14 an an DT cord-010092-uftc8inx 10930 15 appropriate appropriate JJ cord-010092-uftc8inx 10930 16 technique technique NN cord-010092-uftc8inx 10930 17 in in IN cord-010092-uftc8inx 10930 18 severe severe JJ cord-010092-uftc8inx 10930 19 NMO NMO NNP cord-010092-uftc8inx 10930 20 attacks attack NNS cord-010092-uftc8inx 10930 21 . . . cord-010092-uftc8inx 10931 1 This this DT cord-010092-uftc8inx 10931 2 suggests suggest VBZ cord-010092-uftc8inx 10931 3 that that IN cord-010092-uftc8inx 10931 4 TPE TPE NNP cord-010092-uftc8inx 10931 5 is be VBZ cord-010092-uftc8inx 10931 6 beneficial beneficial JJ cord-010092-uftc8inx 10931 7 in in IN cord-010092-uftc8inx 10931 8 NMO NMO NNP cord-010092-uftc8inx 10931 9 patients patient NNS cord-010092-uftc8inx 10931 10 during during IN cord-010092-uftc8inx 10931 11 acute acute JJ cord-010092-uftc8inx 10931 12 attack attack NN cord-010092-uftc8inx 10931 13 if if IN cord-010092-uftc8inx 10931 14 there there EX cord-010092-uftc8inx 10931 15 is be VBZ cord-010092-uftc8inx 10931 16 no no DT cord-010092-uftc8inx 10931 17 response response NN cord-010092-uftc8inx 10931 18 to to IN cord-010092-uftc8inx 10931 19 corticosteroid corticosteroid NN cord-010092-uftc8inx 10931 20 treatment treatment NN cord-010092-uftc8inx 10931 21 . . . cord-010092-uftc8inx 10932 1 Background background NN cord-010092-uftc8inx 10932 2 : : : cord-010092-uftc8inx 10933 1 Babesiosis babesiosis NN cord-010092-uftc8inx 10933 2 is be VBZ cord-010092-uftc8inx 10933 3 a a DT cord-010092-uftc8inx 10933 4 tick tick NN cord-010092-uftc8inx 10933 5 borne bear VBN cord-010092-uftc8inx 10933 6 infectious infectious JJ cord-010092-uftc8inx 10933 7 disease disease NN cord-010092-uftc8inx 10933 8 caused cause VBN cord-010092-uftc8inx 10933 9 by by IN cord-010092-uftc8inx 10933 10 the the DT cord-010092-uftc8inx 10933 11 protozoa protozoan NNS cord-010092-uftc8inx 10933 12 Babesia Babesia NNP cord-010092-uftc8inx 10933 13 . . . cord-010092-uftc8inx 10934 1 While while IN cord-010092-uftc8inx 10934 2 most most JJS cord-010092-uftc8inx 10934 3 infections infection NNS cord-010092-uftc8inx 10934 4 with with IN cord-010092-uftc8inx 10934 5 Babesia Babesia NNP cord-010092-uftc8inx 10934 6 are be VBP cord-010092-uftc8inx 10934 7 asymptomatic asymptomatic JJ cord-010092-uftc8inx 10934 8 , , , cord-010092-uftc8inx 10934 9 some some DT cord-010092-uftc8inx 10934 10 patients patient NNS cord-010092-uftc8inx 10934 11 present present JJ cord-010092-uftc8inx 10934 12 with with IN cord-010092-uftc8inx 10934 13 a a DT cord-010092-uftc8inx 10934 14 symptomatic symptomatic JJ cord-010092-uftc8inx 10934 15 infections infection NNS cord-010092-uftc8inx 10934 16 and and CC cord-010092-uftc8inx 10934 17 rarely rarely RB cord-010092-uftc8inx 10934 18 this this DT cord-010092-uftc8inx 10934 19 can can MD cord-010092-uftc8inx 10934 20 be be VB cord-010092-uftc8inx 10934 21 a a DT cord-010092-uftc8inx 10934 22 severe severe JJ cord-010092-uftc8inx 10934 23 life life NN cord-010092-uftc8inx 10934 24 threatening threaten VBG cord-010092-uftc8inx 10934 25 illness illness NN cord-010092-uftc8inx 10934 26 . . . cord-010092-uftc8inx 10935 1 Treatment treatment NN cord-010092-uftc8inx 10935 2 is be VBZ cord-010092-uftc8inx 10935 3 primarily primarily RB cord-010092-uftc8inx 10935 4 with with IN cord-010092-uftc8inx 10935 5 antibiotics antibiotic NNS cord-010092-uftc8inx 10935 6 but but CC cord-010092-uftc8inx 10935 7 red red JJ cord-010092-uftc8inx 10935 8 cell cell NN cord-010092-uftc8inx 10935 9 exchange exchange NN cord-010092-uftc8inx 10935 10 ( ( -LRB- cord-010092-uftc8inx 10935 11 RCE RCE NNP cord-010092-uftc8inx 10935 12 ) ) -RRB- cord-010092-uftc8inx 10935 13 has have VBZ cord-010092-uftc8inx 10935 14 been be VBN cord-010092-uftc8inx 10935 15 used use VBN cord-010092-uftc8inx 10935 16 in in IN cord-010092-uftc8inx 10935 17 the the DT cord-010092-uftc8inx 10935 18 more more RBR cord-010092-uftc8inx 10935 19 severe severe JJ cord-010092-uftc8inx 10935 20 cases case NNS cord-010092-uftc8inx 10935 21 which which WDT cord-010092-uftc8inx 10935 22 are be VBP cord-010092-uftc8inx 10935 23 characterized characterize VBN cord-010092-uftc8inx 10935 24 by by IN cord-010092-uftc8inx 10935 25 high high JJ cord-010092-uftc8inx 10935 26 grade grade NN cord-010092-uftc8inx 10935 27 parasitemia parasitemia NN cord-010092-uftc8inx 10935 28 , , , cord-010092-uftc8inx 10935 29 evidence evidence NN cord-010092-uftc8inx 10935 30 of of IN cord-010092-uftc8inx 10935 31 severe severe JJ cord-010092-uftc8inx 10935 32 hemolysis hemolysis NN cord-010092-uftc8inx 10935 33 and and CC cord-010092-uftc8inx 10935 34 or or CC cord-010092-uftc8inx 10935 35 multi multi JJ cord-010092-uftc8inx 10935 36 - - JJ cord-010092-uftc8inx 10935 37 organ organ JJ cord-010092-uftc8inx 10935 38 failure failure NN cord-010092-uftc8inx 10935 39 involving involve VBG cord-010092-uftc8inx 10935 40 the the DT cord-010092-uftc8inx 10935 41 kidney kidney NN cord-010092-uftc8inx 10935 42 , , , cord-010092-uftc8inx 10935 43 lung lung NN cord-010092-uftc8inx 10935 44 or or CC cord-010092-uftc8inx 10935 45 liver liver NN cord-010092-uftc8inx 10935 46 . . . cord-010092-uftc8inx 10936 1 A a DT cord-010092-uftc8inx 10936 2 threshold threshold NN cord-010092-uftc8inx 10936 3 parasite parasite NN cord-010092-uftc8inx 10936 4 level level NN cord-010092-uftc8inx 10936 5 of of IN cord-010092-uftc8inx 10936 6 10 10 CD cord-010092-uftc8inx 10936 7 % % NN cord-010092-uftc8inx 10936 8 has have VBZ cord-010092-uftc8inx 10936 9 arbitrarily arbitrarily RB cord-010092-uftc8inx 10936 10 been be VBN cord-010092-uftc8inx 10936 11 applied apply VBN cord-010092-uftc8inx 10936 12 as as IN cord-010092-uftc8inx 10936 13 an an DT cord-010092-uftc8inx 10936 14 indication indication NN cord-010092-uftc8inx 10936 15 for for IN cord-010092-uftc8inx 10936 16 RCE RCE NNP cord-010092-uftc8inx 10936 17 , , , cord-010092-uftc8inx 10936 18 however however RB cord-010092-uftc8inx 10936 19 , , , cord-010092-uftc8inx 10936 20 this this DT cord-010092-uftc8inx 10936 21 threshold threshold NN cord-010092-uftc8inx 10936 22 is be VBZ cord-010092-uftc8inx 10936 23 not not RB cord-010092-uftc8inx 10936 24 evidence evidence NN cord-010092-uftc8inx 10936 25 based base VBN cord-010092-uftc8inx 10936 26 . . . cord-010092-uftc8inx 10937 1 Aims aim VBZ cord-010092-uftc8inx 10937 2 : : : cord-010092-uftc8inx 10938 1 To to TO cord-010092-uftc8inx 10938 2 report report VB cord-010092-uftc8inx 10938 3 on on IN cord-010092-uftc8inx 10938 4 patients patient NNS cord-010092-uftc8inx 10938 5 with with IN cord-010092-uftc8inx 10938 6 babesiosis babesiosis NN cord-010092-uftc8inx 10938 7 and and CC cord-010092-uftc8inx 10938 8 high high JJ cord-010092-uftc8inx 10938 9 grade grade NN cord-010092-uftc8inx 10938 10 parasitemia parasitemia NN cord-010092-uftc8inx 10938 11 who who WP cord-010092-uftc8inx 10938 12 were be VBD cord-010092-uftc8inx 10938 13 treated treat VBN cord-010092-uftc8inx 10938 14 with with IN cord-010092-uftc8inx 10938 15 antibiotics antibiotic NNS cord-010092-uftc8inx 10938 16 only only RB cord-010092-uftc8inx 10938 17 without without IN cord-010092-uftc8inx 10938 18 RCE RCE NNP cord-010092-uftc8inx 10938 19 Methods method NNS cord-010092-uftc8inx 10938 20 : : : cord-010092-uftc8inx 10938 21 Data datum NNS cord-010092-uftc8inx 10938 22 were be VBD cord-010092-uftc8inx 10938 23 collected collect VBN cord-010092-uftc8inx 10938 24 from from IN cord-010092-uftc8inx 10938 25 July July NNP cord-010092-uftc8inx 10938 26 2014 2014 CD cord-010092-uftc8inx 10938 27 to to IN cord-010092-uftc8inx 10938 28 July July NNP cord-010092-uftc8inx 10938 29 2018 2018 CD cord-010092-uftc8inx 10938 30 . . . cord-010092-uftc8inx 10939 1 A a DT cord-010092-uftc8inx 10939 2 case case NN cord-010092-uftc8inx 10939 3 was be VBD cord-010092-uftc8inx 10939 4 defined define VBN cord-010092-uftc8inx 10939 5 as as IN cord-010092-uftc8inx 10939 6 a a DT cord-010092-uftc8inx 10939 7 patient patient NN cord-010092-uftc8inx 10939 8 diagnosed diagnose VBN cord-010092-uftc8inx 10939 9 with with IN cord-010092-uftc8inx 10939 10 babesiosis babesiosis NN cord-010092-uftc8inx 10939 11 for for IN cord-010092-uftc8inx 10939 12 whom whom WP cord-010092-uftc8inx 10939 13 RCE RCE NNP cord-010092-uftc8inx 10939 14 was be VBD cord-010092-uftc8inx 10939 15 requested request VBN cord-010092-uftc8inx 10939 16 on on IN cord-010092-uftc8inx 10939 17 the the DT cord-010092-uftc8inx 10939 18 basis basis NN cord-010092-uftc8inx 10939 19 of of IN cord-010092-uftc8inx 10939 20 a a DT cord-010092-uftc8inx 10939 21 parasitemia parasitemia NN cord-010092-uftc8inx 10939 22 of of IN cord-010092-uftc8inx 10939 23 > > $ cord-010092-uftc8inx 10939 24 10 10 CD cord-010092-uftc8inx 10939 25 % % NN cord-010092-uftc8inx 10939 26 but but CC cord-010092-uftc8inx 10939 27 on on IN cord-010092-uftc8inx 10939 28 clinical clinical JJ cord-010092-uftc8inx 10939 29 evaluation evaluation NN cord-010092-uftc8inx 10939 30 it -PRON- PRP cord-010092-uftc8inx 10939 31 was be VBD cord-010092-uftc8inx 10939 32 considered consider VBN cord-010092-uftc8inx 10939 33 that that IN cord-010092-uftc8inx 10939 34 RCE RCE NNP cord-010092-uftc8inx 10939 35 could could MD cord-010092-uftc8inx 10939 36 be be VB cord-010092-uftc8inx 10939 37 withheld withhold VBN cord-010092-uftc8inx 10939 38 and and CC cord-010092-uftc8inx 10939 39 the the DT cord-010092-uftc8inx 10939 40 patient patient NN cord-010092-uftc8inx 10939 41 monitored monitor VBD cord-010092-uftc8inx 10939 42 awaiting await VBG cord-010092-uftc8inx 10939 43 response response NN cord-010092-uftc8inx 10939 44 to to IN cord-010092-uftc8inx 10939 45 antibiotics antibiotic NNS cord-010092-uftc8inx 10939 46 . . . cord-010092-uftc8inx 10940 1 Results result NNS cord-010092-uftc8inx 10940 2 : : : cord-010092-uftc8inx 10941 1 Three three CD cord-010092-uftc8inx 10941 2 cases case NNS cord-010092-uftc8inx 10941 3 of of IN cord-010092-uftc8inx 10941 4 severe severe JJ cord-010092-uftc8inx 10941 5 babesiosis babesiosis NN cord-010092-uftc8inx 10941 6 in in IN cord-010092-uftc8inx 10941 7 which which WDT cord-010092-uftc8inx 10941 8 the the DT cord-010092-uftc8inx 10941 9 use use NN cord-010092-uftc8inx 10941 10 of of IN cord-010092-uftc8inx 10941 11 RCE RCE NNP cord-010092-uftc8inx 10941 12 was be VBD cord-010092-uftc8inx 10941 13 requested request VBN cord-010092-uftc8inx 10941 14 on on IN cord-010092-uftc8inx 10941 15 the the DT cord-010092-uftc8inx 10941 16 basis basis NN cord-010092-uftc8inx 10941 17 of of IN cord-010092-uftc8inx 10941 18 a a DT cord-010092-uftc8inx 10941 19 parasite parasite NN cord-010092-uftc8inx 10941 20 level level NN cord-010092-uftc8inx 10941 21 of of IN cord-010092-uftc8inx 10941 22 greater great JJR cord-010092-uftc8inx 10941 23 than than IN cord-010092-uftc8inx 10941 24 10 10 CD cord-010092-uftc8inx 10941 25 % % NN cord-010092-uftc8inx 10941 26 , , , cord-010092-uftc8inx 10941 27 but but CC cord-010092-uftc8inx 10941 28 was be VBD cord-010092-uftc8inx 10941 29 not not RB cord-010092-uftc8inx 10941 30 performed perform VBN cord-010092-uftc8inx 10941 31 . . . cord-010092-uftc8inx 10942 1 The the DT cord-010092-uftc8inx 10942 2 RCE RCE NNP cord-010092-uftc8inx 10942 3 was be VBD cord-010092-uftc8inx 10942 4 deferred defer VBN cord-010092-uftc8inx 10942 5 on on IN cord-010092-uftc8inx 10942 6 account account NN cord-010092-uftc8inx 10942 7 of of IN cord-010092-uftc8inx 10942 8 the the DT cord-010092-uftc8inx 10942 9 good good JJ cord-010092-uftc8inx 10942 10 clinical clinical JJ cord-010092-uftc8inx 10942 11 state state NN cord-010092-uftc8inx 10942 12 of of IN cord-010092-uftc8inx 10942 13 the the DT cord-010092-uftc8inx 10942 14 patient patient NN cord-010092-uftc8inx 10942 15 and and CC cord-010092-uftc8inx 10942 16 the the DT cord-010092-uftc8inx 10942 17 absence absence NN cord-010092-uftc8inx 10942 18 of of IN cord-010092-uftc8inx 10942 19 renal renal JJ cord-010092-uftc8inx 10942 20 failure failure NN cord-010092-uftc8inx 10942 21 . . . cord-010092-uftc8inx 10943 1 Levels level NNS cord-010092-uftc8inx 10943 2 of of IN cord-010092-uftc8inx 10943 3 parasite parasite NN cord-010092-uftc8inx 10943 4 at at IN cord-010092-uftc8inx 10943 5 diagnosis diagnosis NN cord-010092-uftc8inx 10943 6 were be VBD cord-010092-uftc8inx 10943 7 10.6 10.6 CD cord-010092-uftc8inx 10943 8 % % NN cord-010092-uftc8inx 10943 9 , , , cord-010092-uftc8inx 10943 10 11 11 CD cord-010092-uftc8inx 10943 11 % % NN cord-010092-uftc8inx 10943 12 and and CC cord-010092-uftc8inx 10943 13 31 31 CD cord-010092-uftc8inx 10943 14 % % NN cord-010092-uftc8inx 10943 15 . . . cord-010092-uftc8inx 10944 1 All all DT cord-010092-uftc8inx 10944 2 patients patient NNS cord-010092-uftc8inx 10944 3 were be VBD cord-010092-uftc8inx 10944 4 followed follow VBN cord-010092-uftc8inx 10944 5 daily daily RB cord-010092-uftc8inx 10944 6 until until IN cord-010092-uftc8inx 10944 7 discharge discharge NN cord-010092-uftc8inx 10944 8 . . . cord-010092-uftc8inx 10945 1 Two two CD cord-010092-uftc8inx 10945 2 of of IN cord-010092-uftc8inx 10945 3 these these DT cord-010092-uftc8inx 10945 4 patients patient NNS cord-010092-uftc8inx 10945 5 had have VBD cord-010092-uftc8inx 10945 6 been be VBN cord-010092-uftc8inx 10945 7 splenectomized splenectomize VBN cord-010092-uftc8inx 10945 8 and and CC cord-010092-uftc8inx 10945 9 each each DT cord-010092-uftc8inx 10945 10 received receive VBD cord-010092-uftc8inx 10945 11 a a DT cord-010092-uftc8inx 10945 12 single single JJ cord-010092-uftc8inx 10945 13 unit unit NN cord-010092-uftc8inx 10945 14 of of IN cord-010092-uftc8inx 10945 15 red red JJ cord-010092-uftc8inx 10945 16 blood blood NN cord-010092-uftc8inx 10945 17 cells cell NNS cord-010092-uftc8inx 10945 18 during during IN cord-010092-uftc8inx 10945 19 the the DT cord-010092-uftc8inx 10945 20 hospitalization hospitalization NN cord-010092-uftc8inx 10945 21 . . . cord-010092-uftc8inx 10946 1 The the DT cord-010092-uftc8inx 10946 2 third third JJ cord-010092-uftc8inx 10946 3 patient patient NN cord-010092-uftc8inx 10946 4 had have VBD cord-010092-uftc8inx 10946 5 a a DT cord-010092-uftc8inx 10946 6 long long JJ cord-010092-uftc8inx 10946 7 history history NN cord-010092-uftc8inx 10946 8 of of IN cord-010092-uftc8inx 10946 9 refractory refractory JJ cord-010092-uftc8inx 10946 10 lymphoma lymphoma NN cord-010092-uftc8inx 10946 11 and and CC cord-010092-uftc8inx 10946 12 was be VBD cord-010092-uftc8inx 10946 13 pancytopenic pancytopenic JJ cord-010092-uftc8inx 10946 14 requiring require VBG cord-010092-uftc8inx 10946 15 multiple multiple JJ cord-010092-uftc8inx 10946 16 transfusions transfusion NNS cord-010092-uftc8inx 10946 17 during during IN cord-010092-uftc8inx 10946 18 the the DT cord-010092-uftc8inx 10946 19 years year NNS cord-010092-uftc8inx 10946 20 before before IN cord-010092-uftc8inx 10946 21 the the DT cord-010092-uftc8inx 10946 22 diagnosis diagnosis NN cord-010092-uftc8inx 10946 23 of of IN cord-010092-uftc8inx 10946 24 babesiosis babesiosi NNS cord-010092-uftc8inx 10946 25 . . . cord-010092-uftc8inx 10947 1 She -PRON- PRP cord-010092-uftc8inx 10947 2 had have VBD cord-010092-uftc8inx 10947 3 transfusion transfusion NN cord-010092-uftc8inx 10947 4 transmitted transmit VBN cord-010092-uftc8inx 10947 5 babesiosis babesiosis NN cord-010092-uftc8inx 10947 6 from from IN cord-010092-uftc8inx 10947 7 a a DT cord-010092-uftc8inx 10947 8 red red JJ cord-010092-uftc8inx 10947 9 blood blood NN cord-010092-uftc8inx 10947 10 cell cell NN cord-010092-uftc8inx 10947 11 transfused transfuse VBD cord-010092-uftc8inx 10947 12 46 46 CD cord-010092-uftc8inx 10947 13 days day NNS cord-010092-uftc8inx 10947 14 prior prior RB cord-010092-uftc8inx 10947 15 to to IN cord-010092-uftc8inx 10947 16 the the DT cord-010092-uftc8inx 10947 17 diagnosis diagnosis NN cord-010092-uftc8inx 10947 18 . . . cord-010092-uftc8inx 10948 1 All all DT cord-010092-uftc8inx 10948 2 three three CD cord-010092-uftc8inx 10948 3 patients patient NNS cord-010092-uftc8inx 10948 4 responded respond VBD cord-010092-uftc8inx 10948 5 well well RB cord-010092-uftc8inx 10948 6 to to IN cord-010092-uftc8inx 10948 7 antibiotics antibiotic NNS cord-010092-uftc8inx 10948 8 and and CC cord-010092-uftc8inx 10948 9 were be VBD cord-010092-uftc8inx 10948 10 discharged discharge VBN cord-010092-uftc8inx 10948 11 between between IN cord-010092-uftc8inx 10948 12 9 9 CD cord-010092-uftc8inx 10948 13 - - SYM cord-010092-uftc8inx 10948 14 16 16 CD cord-010092-uftc8inx 10948 15 days day NNS cord-010092-uftc8inx 10948 16 with with IN cord-010092-uftc8inx 10948 17 undetectable undetectable JJ cord-010092-uftc8inx 10948 18 parasites parasite NNS cord-010092-uftc8inx 10948 19 . . . cord-010092-uftc8inx 10949 1 Summary Summary NNP cord-010092-uftc8inx 10949 2 / / SYM cord-010092-uftc8inx 10949 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 10949 4 : : : cord-010092-uftc8inx 10950 1 This this DT cord-010092-uftc8inx 10950 2 small small JJ cord-010092-uftc8inx 10950 3 case case NN cord-010092-uftc8inx 10950 4 series series NN cord-010092-uftc8inx 10950 5 suggests suggest VBZ cord-010092-uftc8inx 10950 6 that that IN cord-010092-uftc8inx 10950 7 requests request NNS cord-010092-uftc8inx 10950 8 for for IN cord-010092-uftc8inx 10950 9 RCE RCE NNP cord-010092-uftc8inx 10950 10 solely solely RB cord-010092-uftc8inx 10950 11 on on IN cord-010092-uftc8inx 10950 12 the the DT cord-010092-uftc8inx 10950 13 basis basis NN cord-010092-uftc8inx 10950 14 of of IN cord-010092-uftc8inx 10950 15 an an DT cord-010092-uftc8inx 10950 16 arbitrary arbitrary JJ cord-010092-uftc8inx 10950 17 level level NN cord-010092-uftc8inx 10950 18 of of IN cord-010092-uftc8inx 10950 19 parasitemia parasitemia NN cord-010092-uftc8inx 10950 20 should should MD cord-010092-uftc8inx 10950 21 be be VB cord-010092-uftc8inx 10950 22 questioned question VBN cord-010092-uftc8inx 10950 23 and and CC cord-010092-uftc8inx 10950 24 the the DT cord-010092-uftc8inx 10950 25 clinical clinical JJ cord-010092-uftc8inx 10950 26 state state NN cord-010092-uftc8inx 10950 27 and and CC cord-010092-uftc8inx 10950 28 evidence evidence NN cord-010092-uftc8inx 10950 29 of of IN cord-010092-uftc8inx 10950 30 organ organ NN cord-010092-uftc8inx 10950 31 failure failure NN cord-010092-uftc8inx 10950 32 considered consider VBN cord-010092-uftc8inx 10950 33 in in IN cord-010092-uftc8inx 10950 34 the the DT cord-010092-uftc8inx 10950 35 decision decision NN cord-010092-uftc8inx 10950 36 to to TO cord-010092-uftc8inx 10950 37 perform perform VB cord-010092-uftc8inx 10950 38 RCE RCE NNP cord-010092-uftc8inx 10950 39 . . . cord-010092-uftc8inx 10951 1 Abstract Abstract NNP cord-010092-uftc8inx 10951 2 withdrawn withdraw VBN cord-010092-uftc8inx 10951 3 . . . cord-010092-uftc8inx 10952 1 Chronic Chronic NNP cord-010092-uftc8inx 10952 2 Transfusion Transfusion NNP cord-010092-uftc8inx 10952 3 Program Program NNP cord-010092-uftc8inx 10952 4 ( ( -LRB- cord-010092-uftc8inx 10952 5 CTP CTP NNP cord-010092-uftc8inx 10952 6 ) ) -RRB- cord-010092-uftc8inx 10952 7 remains remain VBZ cord-010092-uftc8inx 10952 8 the the DT cord-010092-uftc8inx 10952 9 gold gold JJ cord-010092-uftc8inx 10952 10 standard standard JJ cord-010092-uftc8inx 10952 11 therapy therapy NN cord-010092-uftc8inx 10952 12 for for IN cord-010092-uftc8inx 10952 13 stroke stroke NN cord-010092-uftc8inx 10952 14 prevention prevention NN cord-010092-uftc8inx 10952 15 and and CC cord-010092-uftc8inx 10952 16 for for IN cord-010092-uftc8inx 10952 17 patients patient NNS cord-010092-uftc8inx 10952 18 with with IN cord-010092-uftc8inx 10952 19 a a DT cord-010092-uftc8inx 10952 20 severe severe JJ cord-010092-uftc8inx 10952 21 disease disease NN cord-010092-uftc8inx 10952 22 who who WP cord-010092-uftc8inx 10952 23 have have VBP cord-010092-uftc8inx 10952 24 inadequate inadequate JJ cord-010092-uftc8inx 10952 25 response response NN cord-010092-uftc8inx 10952 26 to to IN cord-010092-uftc8inx 10952 27 hydroxyurea hydroxyurea NNP cord-010092-uftc8inx 10952 28 treatment treatment NN cord-010092-uftc8inx 10952 29 . . . cord-010092-uftc8inx 10953 1 Aims aim VBZ cord-010092-uftc8inx 10953 2 : : : cord-010092-uftc8inx 10953 3 To to TO cord-010092-uftc8inx 10953 4 evaluate evaluate VB cord-010092-uftc8inx 10953 5 the the DT cord-010092-uftc8inx 10953 6 safety safety NN cord-010092-uftc8inx 10953 7 , , , cord-010092-uftc8inx 10953 8 efficacy efficacy NN cord-010092-uftc8inx 10953 9 and and CC cord-010092-uftc8inx 10953 10 cost cost VBD cord-010092-uftc8inx 10953 11 between between IN cord-010092-uftc8inx 10953 12 SCD SCD NNP cord-010092-uftc8inx 10953 13 patients patient NNS cord-010092-uftc8inx 10953 14 on on IN cord-010092-uftc8inx 10953 15 CTP CTP NNP cord-010092-uftc8inx 10953 16 that that WDT cord-010092-uftc8inx 10953 17 underwent undergo VBD cord-010092-uftc8inx 10953 18 both both DT cord-010092-uftc8inx 10953 19 AET AET NNP cord-010092-uftc8inx 10953 20 and and CC cord-010092-uftc8inx 10953 21 Partial Partial NNP cord-010092-uftc8inx 10953 22 Manual Manual NNP cord-010092-uftc8inx 10953 23 Exchange Exchange NNP cord-010092-uftc8inx 10953 24 Transfusion Transfusion NNP cord-010092-uftc8inx 10953 25 ( ( -LRB- cord-010092-uftc8inx 10953 26 pMET pmet JJ cord-010092-uftc8inx 10953 27 ) ) -RRB- cord-010092-uftc8inx 10953 28 procedures procedure NNS cord-010092-uftc8inx 10953 29 . . . cord-010092-uftc8inx 10954 1 Methods method NNS cord-010092-uftc8inx 10954 2 : : : cord-010092-uftc8inx 10955 1 Retrospective retrospective JJ cord-010092-uftc8inx 10955 2 observational observational JJ cord-010092-uftc8inx 10955 3 cohort cohort NN cord-010092-uftc8inx 10955 4 study study NN cord-010092-uftc8inx 10955 5 of of IN cord-010092-uftc8inx 10955 6 patients patient NNS cord-010092-uftc8inx 10955 7 with with IN cord-010092-uftc8inx 10955 8 SCD SCD NNP cord-010092-uftc8inx 10955 9 on on IN cord-010092-uftc8inx 10955 10 CTP CTP NNP cord-010092-uftc8inx 10955 11 that that WDT cord-010092-uftc8inx 10955 12 have have VBP cord-010092-uftc8inx 10955 13 switched switch VBN cord-010092-uftc8inx 10955 14 between between IN cord-010092-uftc8inx 10955 15 pMET pMET NNP cord-010092-uftc8inx 10955 16 and and CC cord-010092-uftc8inx 10955 17 AET AET NNP cord-010092-uftc8inx 10955 18 . . . cord-010092-uftc8inx 10956 1 This this DT cord-010092-uftc8inx 10956 2 study study NN cord-010092-uftc8inx 10956 3 was be VBD cord-010092-uftc8inx 10956 4 carried carry VBN cord-010092-uftc8inx 10956 5 out out RP cord-010092-uftc8inx 10956 6 from from IN cord-010092-uftc8inx 10956 7 01/01/2017 01/01/2017 CD cord-010092-uftc8inx 10956 8 to to IN cord-010092-uftc8inx 10956 9 31/12/2018 31/12/2018 CD cord-010092-uftc8inx 10956 10 in in IN cord-010092-uftc8inx 10956 11 a a DT cord-010092-uftc8inx 10956 12 hospital hospital NN cord-010092-uftc8inx 10956 13 in in IN cord-010092-uftc8inx 10956 14 Portugal Portugal NNP cord-010092-uftc8inx 10956 15 . . . cord-010092-uftc8inx 10957 1 Data datum NNS cord-010092-uftc8inx 10957 2 on on IN cord-010092-uftc8inx 10957 3 patient patient JJ cord-010092-uftc8inx 10957 4 history history NN cord-010092-uftc8inx 10957 5 , , , cord-010092-uftc8inx 10957 6 haematological haematological JJ cord-010092-uftc8inx 10957 7 values value NNS cord-010092-uftc8inx 10957 8 , , , cord-010092-uftc8inx 10957 9 duration duration NN cord-010092-uftc8inx 10957 10 of of IN cord-010092-uftc8inx 10957 11 the the DT cord-010092-uftc8inx 10957 12 procedure procedure NN cord-010092-uftc8inx 10957 13 , , , cord-010092-uftc8inx 10957 14 intervals interval NNS cord-010092-uftc8inx 10957 15 between between IN cord-010092-uftc8inx 10957 16 them -PRON- PRP cord-010092-uftc8inx 10957 17 , , , cord-010092-uftc8inx 10957 18 adverse adverse JJ cord-010092-uftc8inx 10957 19 events event NNS cord-010092-uftc8inx 10957 20 as as RB cord-010092-uftc8inx 10957 21 well well RB cord-010092-uftc8inx 10957 22 as as IN cord-010092-uftc8inx 10957 23 the the DT cord-010092-uftc8inx 10957 24 cost cost NN cord-010092-uftc8inx 10957 25 of of IN cord-010092-uftc8inx 10957 26 material material NN cord-010092-uftc8inx 10957 27 and and CC cord-010092-uftc8inx 10957 28 working working NN cord-010092-uftc8inx 10957 29 hours hour NNS cord-010092-uftc8inx 10957 30 were be VBD cord-010092-uftc8inx 10957 31 collected collect VBN cord-010092-uftc8inx 10957 32 and and CC cord-010092-uftc8inx 10957 33 compared compare VBN cord-010092-uftc8inx 10957 34 between between IN cord-010092-uftc8inx 10957 35 both both DT cord-010092-uftc8inx 10957 36 procedures procedure NNS cord-010092-uftc8inx 10957 37 . . . cord-010092-uftc8inx 10958 1 Results result NNS cord-010092-uftc8inx 10958 2 : : : cord-010092-uftc8inx 10959 1 A a DT cord-010092-uftc8inx 10959 2 total total NN cord-010092-uftc8inx 10959 3 of of IN cord-010092-uftc8inx 10959 4 6 6 CD cord-010092-uftc8inx 10959 5 patients patient NNS cord-010092-uftc8inx 10959 6 met meet VBD cord-010092-uftc8inx 10959 7 the the DT cord-010092-uftc8inx 10959 8 inclusion inclusion NN cord-010092-uftc8inx 10959 9 criteria criterion NNS cord-010092-uftc8inx 10959 10 described describe VBN cord-010092-uftc8inx 10959 11 . . . cord-010092-uftc8inx 10960 1 However however RB cord-010092-uftc8inx 10960 2 , , , cord-010092-uftc8inx 10960 3 1 1 CD cord-010092-uftc8inx 10960 4 patient patient NN cord-010092-uftc8inx 10960 5 was be VBD cord-010092-uftc8inx 10960 6 excluded exclude VBN cord-010092-uftc8inx 10960 7 from from IN cord-010092-uftc8inx 10960 8 our -PRON- PRP$ cord-010092-uftc8inx 10960 9 study study NN cord-010092-uftc8inx 10960 10 because because IN cord-010092-uftc8inx 10960 11 of of IN cord-010092-uftc8inx 10960 12 the the DT cord-010092-uftc8inx 10960 13 lack lack NN cord-010092-uftc8inx 10960 14 of of IN cord-010092-uftc8inx 10960 15 attendance attendance NN cord-010092-uftc8inx 10960 16 to to IN cord-010092-uftc8inx 10960 17 the the DT cord-010092-uftc8inx 10960 18 CTP CTP NNP cord-010092-uftc8inx 10960 19 . . . cord-010092-uftc8inx 10961 1 During during IN cord-010092-uftc8inx 10961 2 the the DT cord-010092-uftc8inx 10961 3 study study NN cord-010092-uftc8inx 10961 4 , , , cord-010092-uftc8inx 10961 5 we -PRON- PRP cord-010092-uftc8inx 10961 6 recorded record VBD cord-010092-uftc8inx 10961 7 88 88 CD cord-010092-uftc8inx 10961 8 exchange exchange NN cord-010092-uftc8inx 10961 9 procedures procedure NNS cord-010092-uftc8inx 10961 10 ( ( -LRB- cord-010092-uftc8inx 10961 11 42 42 CD cord-010092-uftc8inx 10961 12 pMET pmet JJ cord-010092-uftc8inx 10961 13 and and CC cord-010092-uftc8inx 10961 14 46 46 CD cord-010092-uftc8inx 10961 15 AET AET NNP cord-010092-uftc8inx 10961 16 ) ) -RRB- cord-010092-uftc8inx 10961 17 , , , cord-010092-uftc8inx 10961 18 both both DT cord-010092-uftc8inx 10961 19 on on IN cord-010092-uftc8inx 10961 20 peripheral peripheral JJ cord-010092-uftc8inx 10961 21 venous venous JJ cord-010092-uftc8inx 10961 22 access access NN cord-010092-uftc8inx 10961 23 . . . cord-010092-uftc8inx 10962 1 From from IN cord-010092-uftc8inx 10962 2 all all PDT cord-010092-uftc8inx 10962 3 those those DT cord-010092-uftc8inx 10962 4 procedures procedure NNS cord-010092-uftc8inx 10962 5 the the DT cord-010092-uftc8inx 10962 6 major major JJ cord-010092-uftc8inx 10962 7 concern concern NN cord-010092-uftc8inx 10962 8 was be VBD cord-010092-uftc8inx 10962 9 the the DT cord-010092-uftc8inx 10962 10 poor poor JJ cord-010092-uftc8inx 10962 11 venous venous JJ cord-010092-uftc8inx 10962 12 access access NN cord-010092-uftc8inx 10962 13 , , , cord-010092-uftc8inx 10962 14 which which WDT cord-010092-uftc8inx 10962 15 was be VBD cord-010092-uftc8inx 10962 16 the the DT cord-010092-uftc8inx 10962 17 reason reason NN cord-010092-uftc8inx 10962 18 why why WRB cord-010092-uftc8inx 10962 19 2 2 CD cord-010092-uftc8inx 10962 20 patients patient NNS cord-010092-uftc8inx 10962 21 had have VBD cord-010092-uftc8inx 10962 22 returned return VBN cord-010092-uftc8inx 10962 23 to to IN cord-010092-uftc8inx 10962 24 pMET pmet NN cord-010092-uftc8inx 10962 25 . . . cord-010092-uftc8inx 10963 1 No no DT cord-010092-uftc8inx 10963 2 major major JJ cord-010092-uftc8inx 10963 3 complication complication NN cord-010092-uftc8inx 10963 4 or or CC cord-010092-uftc8inx 10963 5 alloimmunization alloimmunization NN cord-010092-uftc8inx 10963 6 was be VBD cord-010092-uftc8inx 10963 7 observed observe VBN cord-010092-uftc8inx 10963 8 . . . cord-010092-uftc8inx 10964 1 The the DT cord-010092-uftc8inx 10964 2 indications indication NNS cord-010092-uftc8inx 10964 3 for for IN cord-010092-uftc8inx 10964 4 CTP CTP NNP cord-010092-uftc8inx 10964 5 were be VBD cord-010092-uftc8inx 10964 6 cerebral cerebral JJ cord-010092-uftc8inx 10964 7 vasculopathy vasculopathy NNP cord-010092-uftc8inx 10964 8 ( ( -LRB- cord-010092-uftc8inx 10964 9 N n NN cord-010092-uftc8inx 10964 10 = = SYM cord-010092-uftc8inx 10964 11 2 2 CD cord-010092-uftc8inx 10964 12 ) ) -RRB- cord-010092-uftc8inx 10964 13 , , , cord-010092-uftc8inx 10964 14 stroke stroke NN cord-010092-uftc8inx 10964 15 ( ( -LRB- cord-010092-uftc8inx 10964 16 N n NN cord-010092-uftc8inx 10964 17 = = SYM cord-010092-uftc8inx 10964 18 1 1 CD cord-010092-uftc8inx 10964 19 ) ) -RRB- cord-010092-uftc8inx 10964 20 and and CC cord-010092-uftc8inx 10964 21 recurrent recurrent JJ cord-010092-uftc8inx 10964 22 vaso vaso JJ cord-010092-uftc8inx 10964 23 - - HYPH cord-010092-uftc8inx 10964 24 occlusive occlusive JJ cord-010092-uftc8inx 10964 25 crisis crisis NN cord-010092-uftc8inx 10964 26 with with IN cord-010092-uftc8inx 10964 27 multiorgan multiorgan NNP cord-010092-uftc8inx 10964 28 failure failure NN cord-010092-uftc8inx 10964 29 ( ( -LRB- cord-010092-uftc8inx 10964 30 N n NN cord-010092-uftc8inx 10964 31 = = SYM cord-010092-uftc8inx 10964 32 2 2 CD cord-010092-uftc8inx 10964 33 ) ) -RRB- cord-010092-uftc8inx 10964 34 . . . cord-010092-uftc8inx 10965 1 For for IN cord-010092-uftc8inx 10965 2 both both DT cord-010092-uftc8inx 10965 3 procedures procedure NNS cord-010092-uftc8inx 10965 4 , , , cord-010092-uftc8inx 10965 5 target target NN cord-010092-uftc8inx 10965 6 values value NNS cord-010092-uftc8inx 10965 7 were be VBD cord-010092-uftc8inx 10965 8 to to TO cord-010092-uftc8inx 10965 9 obtain obtain VB cord-010092-uftc8inx 10965 10 a a DT cord-010092-uftc8inx 10965 11 pre pre JJ cord-010092-uftc8inx 10965 12 - - JJ cord-010092-uftc8inx 10965 13 exchange exchange JJ cord-010092-uftc8inx 10965 14 HbS HbS NNP cord-010092-uftc8inx 10965 15 level level NN cord-010092-uftc8inx 10965 16 ≤ ≤ NNP cord-010092-uftc8inx 10965 17 30 30 CD cord-010092-uftc8inx 10965 18 % % NN cord-010092-uftc8inx 10965 19 for for IN cord-010092-uftc8inx 10965 20 stroke stroke NN cord-010092-uftc8inx 10965 21 and and CC cord-010092-uftc8inx 10965 22 cerebral cerebral JJ cord-010092-uftc8inx 10965 23 vasculopathy vasculopathy NNP cord-010092-uftc8inx 10965 24 and and CC cord-010092-uftc8inx 10965 25 ≤ ≤ NNP cord-010092-uftc8inx 10965 26 50 50 CD cord-010092-uftc8inx 10965 27 - - SYM cord-010092-uftc8inx 10965 28 60 60 CD cord-010092-uftc8inx 10965 29 % % NN cord-010092-uftc8inx 10965 30 for for IN cord-010092-uftc8inx 10965 31 other other JJ cord-010092-uftc8inx 10965 32 indications indication NNS cord-010092-uftc8inx 10965 33 . . . cord-010092-uftc8inx 10966 1 The the DT cord-010092-uftc8inx 10966 2 median median NN cord-010092-uftc8inx 10966 3 HbS hbs JJ cord-010092-uftc8inx 10966 4 level level NN cord-010092-uftc8inx 10966 5 before before IN cord-010092-uftc8inx 10966 6 pMET pMET NNP cord-010092-uftc8inx 10966 7 was be VBD cord-010092-uftc8inx 10966 8 42,6 42,6 CD cord-010092-uftc8inx 10966 9 % % NN cord-010092-uftc8inx 10966 10 ( ( -LRB- cord-010092-uftc8inx 10966 11 31,3 31,3 CD cord-010092-uftc8inx 10966 12 - - HYPH cord-010092-uftc8inx 10966 13 59,1 59,1 CD cord-010092-uftc8inx 10966 14 ) ) -RRB- cord-010092-uftc8inx 10966 15 and and CC cord-010092-uftc8inx 10966 16 38,4 38,4 CD cord-010092-uftc8inx 10966 17 % % NN cord-010092-uftc8inx 10966 18 ( ( -LRB- cord-010092-uftc8inx 10966 19 18 18 CD cord-010092-uftc8inx 10966 20 , , , cord-010092-uftc8inx 10966 21 9 9 CD cord-010092-uftc8inx 10966 22 ) ) -RRB- cord-010092-uftc8inx 10966 23 before before IN cord-010092-uftc8inx 10966 24 AET AET NNP cord-010092-uftc8inx 10966 25 . . . cord-010092-uftc8inx 10967 1 We -PRON- PRP cord-010092-uftc8inx 10967 2 documented document VBD cord-010092-uftc8inx 10967 3 a a DT cord-010092-uftc8inx 10967 4 higher high JJR cord-010092-uftc8inx 10967 5 HbS hbs JJ cord-010092-uftc8inx 10967 6 level level NN cord-010092-uftc8inx 10967 7 prior prior RB cord-010092-uftc8inx 10967 8 to to IN cord-010092-uftc8inx 10967 9 the the DT cord-010092-uftc8inx 10967 10 next next JJ cord-010092-uftc8inx 10967 11 procedure procedure NN cord-010092-uftc8inx 10967 12 in in IN cord-010092-uftc8inx 10967 13 11,4 11,4 CD cord-010092-uftc8inx 10967 14 % % NN cord-010092-uftc8inx 10967 15 of of IN cord-010092-uftc8inx 10967 16 patients patient NNS cord-010092-uftc8inx 10967 17 ( ( -LRB- cord-010092-uftc8inx 10967 18 N n NN cord-010092-uftc8inx 10967 19 = = SYM cord-010092-uftc8inx 10967 20 10 10 CD cord-010092-uftc8inx 10967 21 ) ) -RRB- cord-010092-uftc8inx 10967 22 . . . cord-010092-uftc8inx 10968 1 Despite despite IN cord-010092-uftc8inx 10968 2 that that IN cord-010092-uftc8inx 10968 3 all all DT cord-010092-uftc8inx 10968 4 patients patient NNS cord-010092-uftc8inx 10968 5 remained remain VBD cord-010092-uftc8inx 10968 6 stable stable JJ cord-010092-uftc8inx 10968 7 without without IN cord-010092-uftc8inx 10968 8 any any DT cord-010092-uftc8inx 10968 9 major major JJ cord-010092-uftc8inx 10968 10 SCD SCD NNP cord-010092-uftc8inx 10968 11 related relate VBN cord-010092-uftc8inx 10968 12 event event NN cord-010092-uftc8inx 10968 13 . . . cord-010092-uftc8inx 10969 1 Both both DT cord-010092-uftc8inx 10969 2 procedures procedure NNS cord-010092-uftc8inx 10969 3 were be VBD cord-010092-uftc8inx 10969 4 well well RB cord-010092-uftc8inx 10969 5 tolerated tolerate VBN cord-010092-uftc8inx 10969 6 and and CC cord-010092-uftc8inx 10969 7 iron iron NN cord-010092-uftc8inx 10969 8 overload overload NN cord-010092-uftc8inx 10969 9 was be VBD cord-010092-uftc8inx 10969 10 well well RB cord-010092-uftc8inx 10969 11 controlled control VBN cord-010092-uftc8inx 10970 1 ( ( -LRB- cord-010092-uftc8inx 10970 2 median median JJ cord-010092-uftc8inx 10970 3 ferritin ferritin NN cord-010092-uftc8inx 10970 4 level level NN cord-010092-uftc8inx 10970 5 pMET pmet NN cord-010092-uftc8inx 10970 6 : : : cord-010092-uftc8inx 10970 7 1356,1 1356,1 CD cord-010092-uftc8inx 10970 8 vs. vs. IN cord-010092-uftc8inx 10970 9 AET aet NN cord-010092-uftc8inx 10970 10 : : : cord-010092-uftc8inx 10971 1 1314,7 1314,7 CD cord-010092-uftc8inx 10971 2 ng ng NN cord-010092-uftc8inx 10971 3 / / SYM cord-010092-uftc8inx 10971 4 mL mL NNP cord-010092-uftc8inx 10971 5 ) ) -RRB- cord-010092-uftc8inx 10971 6 . . . cord-010092-uftc8inx 10972 1 The the DT cord-010092-uftc8inx 10972 2 duration duration NN cord-010092-uftc8inx 10972 3 of of IN cord-010092-uftc8inx 10972 4 the the DT cord-010092-uftc8inx 10972 5 exchange exchange NN cord-010092-uftc8inx 10972 6 procedure procedure NN cord-010092-uftc8inx 10972 7 was be VBD cord-010092-uftc8inx 10972 8 longer long JJR cord-010092-uftc8inx 10972 9 and and CC cord-010092-uftc8inx 10972 10 the the DT cord-010092-uftc8inx 10972 11 intervals interval NNS cord-010092-uftc8inx 10972 12 between between IN cord-010092-uftc8inx 10972 13 procedures procedure NNS cord-010092-uftc8inx 10972 14 were be VBD cord-010092-uftc8inx 10972 15 shorter short JJR cord-010092-uftc8inx 10972 16 with with IN cord-010092-uftc8inx 10972 17 pMET pmet JJ cord-010092-uftc8inx 10972 18 ( ( -LRB- cord-010092-uftc8inx 10972 19 median median JJ cord-010092-uftc8inx 10972 20 pMET pmet JJ cord-010092-uftc8inx 10972 21 : : : cord-010092-uftc8inx 10972 22 360 360 CD cord-010092-uftc8inx 10972 23 vs. vs. IN cord-010092-uftc8inx 10972 24 AET aet NN cord-010092-uftc8inx 10972 25 : : : cord-010092-uftc8inx 10972 26 60 60 CD cord-010092-uftc8inx 10972 27 min min NN cord-010092-uftc8inx 10972 28 and and CC cord-010092-uftc8inx 10972 29 pMET pmet JJ cord-010092-uftc8inx 10972 30 : : : cord-010092-uftc8inx 10972 31 21 21 CD cord-010092-uftc8inx 10972 32 vs. vs. IN cord-010092-uftc8inx 10972 33 AET aet NN cord-010092-uftc8inx 10972 34 : : : cord-010092-uftc8inx 10972 35 24 24 CD cord-010092-uftc8inx 10972 36 weeks week NNS cord-010092-uftc8inx 10972 37 , , , cord-010092-uftc8inx 10972 38 respectively respectively RB cord-010092-uftc8inx 10972 39 ) ) -RRB- cord-010092-uftc8inx 10972 40 . . . cord-010092-uftc8inx 10973 1 Annual annual JJ cord-010092-uftc8inx 10973 2 RBC RBC NNP cord-010092-uftc8inx 10973 3 requirements requirement NNS cord-010092-uftc8inx 10973 4 per per IN cord-010092-uftc8inx 10973 5 procedure procedure NN cord-010092-uftc8inx 10973 6 were be VBD cord-010092-uftc8inx 10973 7 superior superior JJ cord-010092-uftc8inx 10973 8 ( ( -LRB- cord-010092-uftc8inx 10973 9 median median JJ cord-010092-uftc8inx 10973 10 2 2 CD cord-010092-uftc8inx 10973 11 vs. vs. NN cord-010092-uftc8inx 10973 12 4 4 CD cord-010092-uftc8inx 10973 13 units unit NNS cord-010092-uftc8inx 10973 14 ) ) -RRB- cord-010092-uftc8inx 10973 15 and and CC cord-010092-uftc8inx 10973 16 the the DT cord-010092-uftc8inx 10973 17 overall overall JJ cord-010092-uftc8inx 10973 18 costs cost NNS cord-010092-uftc8inx 10973 19 related relate VBN cord-010092-uftc8inx 10973 20 with with IN cord-010092-uftc8inx 10973 21 AET AET NNP cord-010092-uftc8inx 10973 22 were be VBD cord-010092-uftc8inx 10973 23 2,2 2,2 CD cord-010092-uftc8inx 10973 24 times time NNS cord-010092-uftc8inx 10973 25 higher high JJR cord-010092-uftc8inx 10974 1 -18.180,93 -18.180,93 . cord-010092-uftc8inx 10975 1 € € $ cord-010092-uftc8inx 10975 2 and and CC cord-010092-uftc8inx 10975 3 8.174,79 8.174,79 CD cord-010092-uftc8inx 10975 4 € € NN cord-010092-uftc8inx 10975 5 AET aet NN cord-010092-uftc8inx 10975 6 and and CC cord-010092-uftc8inx 10975 7 pMET pmet NN cord-010092-uftc8inx 10975 8 , , , cord-010092-uftc8inx 10976 1 respectively respectively RB cord-010092-uftc8inx 10976 2 ( ( -LRB- cord-010092-uftc8inx 10976 3 estimated estimate VBN cord-010092-uftc8inx 10976 4 cost cost NN cord-010092-uftc8inx 10976 5 per per IN cord-010092-uftc8inx 10976 6 session session NN cord-010092-uftc8inx 10976 7 AET aet NN cord-010092-uftc8inx 10976 8 : : : cord-010092-uftc8inx 10976 9 790,48 790,48 NNP cord-010092-uftc8inx 10976 10 € € SYM cord-010092-uftc8inx 10976 11 and and CC cord-010092-uftc8inx 10976 12 pMET pmet JJ cord-010092-uftc8inx 10976 13 : : : cord-010092-uftc8inx 10976 14 389,28 389,28 CD cord-010092-uftc8inx 10976 15 € € CD cord-010092-uftc8inx 10976 16 ) ) -RRB- cord-010092-uftc8inx 10976 17 . . . cord-010092-uftc8inx 10977 1 Summary Summary NNP cord-010092-uftc8inx 10977 2 / / SYM cord-010092-uftc8inx 10977 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 10977 4 : : : cord-010092-uftc8inx 10978 1 Our -PRON- PRP$ cord-010092-uftc8inx 10978 2 study study NN cord-010092-uftc8inx 10978 3 shows show VBZ cord-010092-uftc8inx 10978 4 , , , cord-010092-uftc8inx 10978 5 that that IN cord-010092-uftc8inx 10978 6 the the DT cord-010092-uftc8inx 10978 7 HbS hbs JJ cord-010092-uftc8inx 10978 8 level level NN cord-010092-uftc8inx 10978 9 before before IN cord-010092-uftc8inx 10978 10 both both DT cord-010092-uftc8inx 10978 11 procedures procedure NNS cord-010092-uftc8inx 10978 12 , , , cord-010092-uftc8inx 10978 13 performed perform VBN cord-010092-uftc8inx 10978 14 during during IN cord-010092-uftc8inx 10978 15 the the DT cord-010092-uftc8inx 10978 16 same same JJ cord-010092-uftc8inx 10978 17 interval interval NN cord-010092-uftc8inx 10978 18 , , , cord-010092-uftc8inx 10978 19 was be VBD cord-010092-uftc8inx 10978 20 similar similar JJ cord-010092-uftc8inx 10978 21 . . . cord-010092-uftc8inx 10979 1 We -PRON- PRP cord-010092-uftc8inx 10979 2 verified verify VBD cord-010092-uftc8inx 10979 3 that that IN cord-010092-uftc8inx 10979 4 pMET pMET NNP cord-010092-uftc8inx 10979 5 has have VBZ cord-010092-uftc8inx 10979 6 a a DT cord-010092-uftc8inx 10979 7 comparable comparable JJ cord-010092-uftc8inx 10979 8 efficacy efficacy NN cord-010092-uftc8inx 10979 9 with with IN cord-010092-uftc8inx 10979 10 AET aet NN cord-010092-uftc8inx 10979 11 in in IN cord-010092-uftc8inx 10979 12 terms term NNS cord-010092-uftc8inx 10979 13 of of IN cord-010092-uftc8inx 10979 14 preventing prevent VBG cord-010092-uftc8inx 10979 15 the the DT cord-010092-uftc8inx 10979 16 development development NN cord-010092-uftc8inx 10979 17 or or CC cord-010092-uftc8inx 10979 18 progression progression NN cord-010092-uftc8inx 10979 19 of of IN cord-010092-uftc8inx 10979 20 chronic chronic JJ cord-010092-uftc8inx 10979 21 complications complication NNS cord-010092-uftc8inx 10979 22 and and CC cord-010092-uftc8inx 10979 23 that that IN cord-010092-uftc8inx 10979 24 the the DT cord-010092-uftc8inx 10979 25 cost cost NN cord-010092-uftc8inx 10979 26 per per IN cord-010092-uftc8inx 10979 27 procedure procedure NN cord-010092-uftc8inx 10979 28 is be VBZ cord-010092-uftc8inx 10979 29 significantly significantly RB cord-010092-uftc8inx 10979 30 higher high JJR cord-010092-uftc8inx 10979 31 with with IN cord-010092-uftc8inx 10979 32 AET AET NNP cord-010092-uftc8inx 10979 33 . . . cord-010092-uftc8inx 10980 1 However however RB cord-010092-uftc8inx 10980 2 , , , cord-010092-uftc8inx 10980 3 in in IN cord-010092-uftc8inx 10980 4 a a DT cord-010092-uftc8inx 10980 5 clinical clinical JJ cord-010092-uftc8inx 10980 6 situation situation NN cord-010092-uftc8inx 10980 7 where where WRB cord-010092-uftc8inx 10980 8 it -PRON- PRP cord-010092-uftc8inx 10980 9 is be VBZ cord-010092-uftc8inx 10980 10 important important JJ cord-010092-uftc8inx 10980 11 to to TO cord-010092-uftc8inx 10980 12 rapidly rapidly RB cord-010092-uftc8inx 10980 13 reduce reduce VB cord-010092-uftc8inx 10980 14 the the DT cord-010092-uftc8inx 10980 15 HbS hbs JJ cord-010092-uftc8inx 10980 16 level level NN cord-010092-uftc8inx 10980 17 , , , cord-010092-uftc8inx 10980 18 and/or and/or CC cord-010092-uftc8inx 10980 19 where where WRB cord-010092-uftc8inx 10980 20 the the DT cord-010092-uftc8inx 10980 21 control control NN cord-010092-uftc8inx 10980 22 of of IN cord-010092-uftc8inx 10980 23 the the DT cord-010092-uftc8inx 10980 24 target target NN cord-010092-uftc8inx 10980 25 HbS hb VBN cord-010092-uftc8inx 10980 26 is be VBZ cord-010092-uftc8inx 10980 27 stricter strict JJR cord-010092-uftc8inx 10980 28 so so IN cord-010092-uftc8inx 10980 29 that that IN cord-010092-uftc8inx 10980 30 the the DT cord-010092-uftc8inx 10980 31 patients patient NNS cord-010092-uftc8inx 10980 32 are be VBP cord-010092-uftc8inx 10980 33 clinically clinically RB cord-010092-uftc8inx 10980 34 controlled control VBN cord-010092-uftc8inx 10980 35 without without IN cord-010092-uftc8inx 10980 36 an an DT cord-010092-uftc8inx 10980 37 increase increase NN cord-010092-uftc8inx 10980 38 in in IN cord-010092-uftc8inx 10980 39 hospital hospital NN cord-010092-uftc8inx 10980 40 visits visit NNS cord-010092-uftc8inx 10980 41 , , , cord-010092-uftc8inx 10980 42 AET AET NNP cord-010092-uftc8inx 10980 43 is be VBZ cord-010092-uftc8inx 10980 44 preferred prefer VBN cord-010092-uftc8inx 10980 45 . . . cord-010092-uftc8inx 10981 1 We -PRON- PRP cord-010092-uftc8inx 10981 2 conclude conclude VBP cord-010092-uftc8inx 10981 3 that that IN cord-010092-uftc8inx 10981 4 AET AET NNP cord-010092-uftc8inx 10981 5 is be VBZ cord-010092-uftc8inx 10981 6 more more RBR cord-010092-uftc8inx 10981 7 effective effective JJ cord-010092-uftc8inx 10981 8 in in IN cord-010092-uftc8inx 10981 9 the the DT cord-010092-uftc8inx 10981 10 rapid rapid JJ cord-010092-uftc8inx 10981 11 reduction reduction NN cord-010092-uftc8inx 10981 12 of of IN cord-010092-uftc8inx 10981 13 HbS hbs NN cord-010092-uftc8inx 10981 14 and and CC cord-010092-uftc8inx 10981 15 ferritin ferritin NN cord-010092-uftc8inx 10981 16 levels level NNS cord-010092-uftc8inx 10981 17 , , , cord-010092-uftc8inx 10981 18 as as RB cord-010092-uftc8inx 10981 19 well well RB cord-010092-uftc8inx 10981 20 as as IN cord-010092-uftc8inx 10981 21 being be VBG cord-010092-uftc8inx 10981 22 less less JJR cord-010092-uftc8inx 10981 23 time time NN cord-010092-uftc8inx 10981 24 consuming consume VBG cord-010092-uftc8inx 10981 25 . . . cord-010092-uftc8inx 10982 1 Despite despite IN cord-010092-uftc8inx 10982 2 this this DT cord-010092-uftc8inx 10982 3 , , , cord-010092-uftc8inx 10982 4 for for IN cord-010092-uftc8inx 10982 5 the the DT cord-010092-uftc8inx 10982 6 reasons reason NNS cord-010092-uftc8inx 10982 7 described describe VBN cord-010092-uftc8inx 10982 8 above above RB cord-010092-uftc8inx 10982 9 , , , cord-010092-uftc8inx 10982 10 it -PRON- PRP cord-010092-uftc8inx 10982 11 is be VBZ cord-010092-uftc8inx 10982 12 more more RBR cord-010092-uftc8inx 10982 13 cost cost NN cord-010092-uftc8inx 10982 14 - - HYPH cord-010092-uftc8inx 10982 15 effective effective JJ cord-010092-uftc8inx 10982 16 to to TO cord-010092-uftc8inx 10982 17 maintain maintain VB cord-010092-uftc8inx 10982 18 both both DT cord-010092-uftc8inx 10982 19 AET aet NN cord-010092-uftc8inx 10982 20 and and CC cord-010092-uftc8inx 10982 21 pMET pmet JJ cord-010092-uftc8inx 10982 22 procedures procedure NNS cord-010092-uftc8inx 10982 23 . . . cord-010092-uftc8inx 10983 1 Background background NN cord-010092-uftc8inx 10983 2 : : : cord-010092-uftc8inx 10984 1 Erythrocytapheresis erythrocytapheresis NN cord-010092-uftc8inx 10984 2 / / SYM cord-010092-uftc8inx 10984 3 Red Red NNP cord-010092-uftc8inx 10984 4 Blood Blood NNP cord-010092-uftc8inx 10984 5 Cell Cell NNP cord-010092-uftc8inx 10984 6 ( ( -LRB- cord-010092-uftc8inx 10984 7 RBC RBC NNP cord-010092-uftc8inx 10984 8 ) ) -RRB- cord-010092-uftc8inx 10984 9 exchange exchange NN cord-010092-uftc8inx 10984 10 , , , cord-010092-uftc8inx 10984 11 involves involve VBZ cord-010092-uftc8inx 10984 12 removing remove VBG cord-010092-uftc8inx 10984 13 of of IN cord-010092-uftc8inx 10984 14 a a DT cord-010092-uftc8inx 10984 15 large large JJ cord-010092-uftc8inx 10984 16 number number NN cord-010092-uftc8inx 10984 17 of of IN cord-010092-uftc8inx 10984 18 RBCs rbc NNS cord-010092-uftc8inx 10984 19 from from IN cord-010092-uftc8inx 10984 20 the the DT cord-010092-uftc8inx 10984 21 patient patient NN cord-010092-uftc8inx 10984 22 and and CC cord-010092-uftc8inx 10984 23 returning return VBG cord-010092-uftc8inx 10984 24 the the DT cord-010092-uftc8inx 10984 25 patient patient NN cord-010092-uftc8inx 10984 26 's 's POS cord-010092-uftc8inx 10984 27 plasma plasma NN cord-010092-uftc8inx 10984 28 and and CC cord-010092-uftc8inx 10984 29 platelets platelet NNS cord-010092-uftc8inx 10984 30 along along IN cord-010092-uftc8inx 10984 31 with with IN cord-010092-uftc8inx 10984 32 compatible compatible JJ cord-010092-uftc8inx 10984 33 allogenic allogenic JJ cord-010092-uftc8inx 10984 34 donor donor NN cord-010092-uftc8inx 10984 35 RBCs rbc NNS cord-010092-uftc8inx 10984 36 . . . cord-010092-uftc8inx 10985 1 Typical typical JJ cord-010092-uftc8inx 10985 2 indication indication NN cord-010092-uftc8inx 10985 3 for for IN cord-010092-uftc8inx 10985 4 RBC RBC NNP cord-010092-uftc8inx 10985 5 exchange exchange NN cord-010092-uftc8inx 10985 6 is be VBZ cord-010092-uftc8inx 10985 7 Sickle Sickle NNP cord-010092-uftc8inx 10985 8 Cell Cell NNP cord-010092-uftc8inx 10985 9 disease disease NN cord-010092-uftc8inx 10985 10 and and CC cord-010092-uftc8inx 10985 11 its -PRON- PRP$ cord-010092-uftc8inx 10985 12 related related JJ cord-010092-uftc8inx 10985 13 complications complication NNS cord-010092-uftc8inx 10985 14 . . . cord-010092-uftc8inx 10986 1 However however RB cord-010092-uftc8inx 10986 2 , , , cord-010092-uftc8inx 10986 3 one one CD cord-010092-uftc8inx 10986 4 of of IN cord-010092-uftc8inx 10986 5 the the DT cord-010092-uftc8inx 10986 6 miscellaneous miscellaneous JJ cord-010092-uftc8inx 10986 7 indications indication NNS cord-010092-uftc8inx 10986 8 of of IN cord-010092-uftc8inx 10986 9 RBC RBC NNP cord-010092-uftc8inx 10986 10 exchange exchange NN cord-010092-uftc8inx 10986 11 is be VBZ cord-010092-uftc8inx 10986 12 for for IN cord-010092-uftc8inx 10986 13 the the DT cord-010092-uftc8inx 10986 14 patients patient NNS cord-010092-uftc8inx 10986 15 of of IN cord-010092-uftc8inx 10986 16 methemoglobinemia methemoglobinemia NN cord-010092-uftc8inx 10986 17 who who WP cord-010092-uftc8inx 10986 18 are be VBP cord-010092-uftc8inx 10986 19 refractory refractory JJ cord-010092-uftc8inx 10986 20 to to IN cord-010092-uftc8inx 10986 21 treatment treatment NN cord-010092-uftc8inx 10986 22 by by IN cord-010092-uftc8inx 10986 23 methylene methylene NN cord-010092-uftc8inx 10986 24 blue blue NN cord-010092-uftc8inx 10986 25 . . . cord-010092-uftc8inx 10987 1 Acquired acquire VBN cord-010092-uftc8inx 10987 2 methemoglobinemia methemoglobinemia NN cord-010092-uftc8inx 10987 3 is be VBZ cord-010092-uftc8inx 10987 4 more more RBR cord-010092-uftc8inx 10987 5 common common JJ cord-010092-uftc8inx 10987 6 than than IN cord-010092-uftc8inx 10987 7 any any DT cord-010092-uftc8inx 10987 8 genetic genetic JJ cord-010092-uftc8inx 10987 9 causes cause NNS cord-010092-uftc8inx 10987 10 . . . cord-010092-uftc8inx 10988 1 Acquired acquire VBN cord-010092-uftc8inx 10988 2 methemoglobinemia methemoglobinemia NN cord-010092-uftc8inx 10988 3 is be VBZ cord-010092-uftc8inx 10988 4 caused cause VBN cord-010092-uftc8inx 10988 5 by by IN cord-010092-uftc8inx 10988 6 toxins toxin NNS cord-010092-uftc8inx 10988 7 that that WDT cord-010092-uftc8inx 10988 8 oxidize oxidize VBP cord-010092-uftc8inx 10988 9 heme heme NN cord-010092-uftc8inx 10988 10 iron iron NN cord-010092-uftc8inx 10988 11 , , , cord-010092-uftc8inx 10988 12 notably notably RB cord-010092-uftc8inx 10988 13 nitrate nitrate NN cord-010092-uftc8inx 10988 14 and and CC cord-010092-uftc8inx 10988 15 nitrite nitrite NN cord-010092-uftc8inx 10988 16 - - HYPH cord-010092-uftc8inx 10988 17 containing contain VBG cord-010092-uftc8inx 10988 18 compounds compound NNS cord-010092-uftc8inx 10988 19 . . . cord-010092-uftc8inx 10989 1 For for IN cord-010092-uftc8inx 10989 2 patients patient NNS cord-010092-uftc8inx 10989 3 failing fail VBG cord-010092-uftc8inx 10989 4 to to TO cord-010092-uftc8inx 10989 5 respond respond VB cord-010092-uftc8inx 10989 6 to to IN cord-010092-uftc8inx 10989 7 standard standard JJ cord-010092-uftc8inx 10989 8 treatment treatment NN cord-010092-uftc8inx 10989 9 with with IN cord-010092-uftc8inx 10989 10 methylene methylene NN cord-010092-uftc8inx 10989 11 blue blue JJ cord-010092-uftc8inx 10989 12 or or CC cord-010092-uftc8inx 10989 13 in in IN cord-010092-uftc8inx 10989 14 whom whom WP cord-010092-uftc8inx 10989 15 its -PRON- PRP$ cord-010092-uftc8inx 10989 16 use use NN cord-010092-uftc8inx 10989 17 is be VBZ cord-010092-uftc8inx 10989 18 contraindicated contraindicate VBN cord-010092-uftc8inx 10989 19 ; ; : cord-010092-uftc8inx 10989 20 hyperbaric hyperbaric NN cord-010092-uftc8inx 10989 21 oxygen oxygen NN cord-010092-uftc8inx 10989 22 or or CC cord-010092-uftc8inx 10989 23 RBC RBC NNP cord-010092-uftc8inx 10989 24 exchange exchange NN cord-010092-uftc8inx 10989 25 is be VBZ cord-010092-uftc8inx 10989 26 indicated indicate VBN cord-010092-uftc8inx 10989 27 Aims aim VBZ cord-010092-uftc8inx 10989 28 : : : cord-010092-uftc8inx 10990 1 Case case NN cord-010092-uftc8inx 10990 2 reports report NNS cord-010092-uftc8inx 10990 3 on on IN cord-010092-uftc8inx 10990 4 use use NN cord-010092-uftc8inx 10990 5 of of IN cord-010092-uftc8inx 10990 6 RBC RBC NNP cord-010092-uftc8inx 10990 7 exchange exchange NN cord-010092-uftc8inx 10990 8 in in IN cord-010092-uftc8inx 10990 9 methemoglobinemia methemoglobinemia NN cord-010092-uftc8inx 10990 10 are be VBP cord-010092-uftc8inx 10990 11 few few JJ cord-010092-uftc8inx 10990 12 and and CC cord-010092-uftc8inx 10990 13 indications indication NNS cord-010092-uftc8inx 10990 14 are be VBP cord-010092-uftc8inx 10990 15 based base VBN cord-010092-uftc8inx 10990 16 on on IN cord-010092-uftc8inx 10990 17 anecdotal anecdotal JJ cord-010092-uftc8inx 10990 18 reports report NNS cord-010092-uftc8inx 10990 19 . . . cord-010092-uftc8inx 10991 1 Methods method NNS cord-010092-uftc8inx 10991 2 : : : cord-010092-uftc8inx 10991 3 Exchange Exchange NNP cord-010092-uftc8inx 10991 4 was be VBD cord-010092-uftc8inx 10991 5 performed perform VBN cord-010092-uftc8inx 10991 6 on on IN cord-010092-uftc8inx 10991 7 the the DT cord-010092-uftc8inx 10991 8 Cell Cell NNP cord-010092-uftc8inx 10991 9 Separator Separator NNP cord-010092-uftc8inx 10991 10 machine machine NN cord-010092-uftc8inx 10991 11 , , , cord-010092-uftc8inx 10991 12 Com Com NNP cord-010092-uftc8inx 10991 13 Tec Tec NNP cord-010092-uftc8inx 10991 14 by by IN cord-010092-uftc8inx 10991 15 Fresenius Fresenius NNP cord-010092-uftc8inx 10991 16 Kabi Kabi NNP cord-010092-uftc8inx 10991 17 . . . cord-010092-uftc8inx 10992 1 Results result NNS cord-010092-uftc8inx 10992 2 : : : cord-010092-uftc8inx 10993 1 We -PRON- PRP cord-010092-uftc8inx 10993 2 report report VBP cord-010092-uftc8inx 10993 3 a a DT cord-010092-uftc8inx 10993 4 case case NN cord-010092-uftc8inx 10993 5 of of IN cord-010092-uftc8inx 10993 6 acquired acquire VBN cord-010092-uftc8inx 10993 7 methemoglobinemia methemoglobinemia NN cord-010092-uftc8inx 10993 8 where where WRB cord-010092-uftc8inx 10993 9 patient patient NN cord-010092-uftc8inx 10993 10 was be VBD cord-010092-uftc8inx 10993 11 admitted admit VBN cord-010092-uftc8inx 10993 12 with with IN cord-010092-uftc8inx 10993 13 peripheral peripheral JJ cord-010092-uftc8inx 10993 14 capillary capillary JJ cord-010092-uftc8inx 10993 15 oxygen oxygen NN cord-010092-uftc8inx 10993 16 saturation saturation NN cord-010092-uftc8inx 10993 17 ( ( -LRB- cord-010092-uftc8inx 10993 18 SpO2 SpO2 NNP cord-010092-uftc8inx 10993 19 ) ) -RRB- cord-010092-uftc8inx 10993 20 of of IN cord-010092-uftc8inx 10993 21 87 87 CD cord-010092-uftc8inx 10993 22 % % NN cord-010092-uftc8inx 10993 23 on on IN cord-010092-uftc8inx 10993 24 air air NN cord-010092-uftc8inx 10993 25 . . . cord-010092-uftc8inx 10994 1 The the DT cord-010092-uftc8inx 10994 2 patient patient NN cord-010092-uftc8inx 10994 3 did do VBD cord-010092-uftc8inx 10994 4 not not RB cord-010092-uftc8inx 10994 5 show show VB cord-010092-uftc8inx 10994 6 improvement improvement NN cord-010092-uftc8inx 10994 7 in in IN cord-010092-uftc8inx 10994 8 SpO2 spo2 JJ cord-010092-uftc8inx 10994 9 level level NN cord-010092-uftc8inx 10994 10 with with IN cord-010092-uftc8inx 10994 11 effective effective JJ cord-010092-uftc8inx 10994 12 emergency emergency NN cord-010092-uftc8inx 10994 13 treatment treatment NN cord-010092-uftc8inx 10994 14 of of IN cord-010092-uftc8inx 10994 15 methylene methylene NN cord-010092-uftc8inx 10994 16 blue blue NN cord-010092-uftc8inx 10994 17 . . . cord-010092-uftc8inx 10995 1 Since since IN cord-010092-uftc8inx 10995 2 , , , cord-010092-uftc8inx 10995 3 the the DT cord-010092-uftc8inx 10995 4 patient patient NN cord-010092-uftc8inx 10995 5 was be VBD cord-010092-uftc8inx 10995 6 refractory refractory JJ cord-010092-uftc8inx 10995 7 to to IN cord-010092-uftc8inx 10995 8 treatment treatment NN cord-010092-uftc8inx 10995 9 with with IN cord-010092-uftc8inx 10995 10 methylene methylene NN cord-010092-uftc8inx 10995 11 blue blue NN cord-010092-uftc8inx 10995 12 , , , cord-010092-uftc8inx 10995 13 the the DT cord-010092-uftc8inx 10995 14 decision decision NN cord-010092-uftc8inx 10995 15 was be VBD cord-010092-uftc8inx 10995 16 made make VBN cord-010092-uftc8inx 10995 17 by by IN cord-010092-uftc8inx 10995 18 clinician clinician NN cord-010092-uftc8inx 10995 19 to to TO cord-010092-uftc8inx 10995 20 proceed proceed VB cord-010092-uftc8inx 10995 21 with with IN cord-010092-uftc8inx 10995 22 RBC RBC NNP cord-010092-uftc8inx 10995 23 exchange exchange NN cord-010092-uftc8inx 10995 24 . . . cord-010092-uftc8inx 10996 1 The the DT cord-010092-uftc8inx 10996 2 patient patient NN cord-010092-uftc8inx 10996 3 improved improve VBD cord-010092-uftc8inx 10996 4 significantly significantly RB cord-010092-uftc8inx 10996 5 after after IN cord-010092-uftc8inx 10996 6 two two CD cord-010092-uftc8inx 10996 7 cycles cycle NNS cord-010092-uftc8inx 10996 8 of of IN cord-010092-uftc8inx 10996 9 one one CD cord-010092-uftc8inx 10996 10 RBC RBC NNP cord-010092-uftc8inx 10996 11 volume volume NN cord-010092-uftc8inx 10996 12 automated automate VBN cord-010092-uftc8inx 10996 13 RBC RBC NNP cord-010092-uftc8inx 10996 14 exchange exchange NN cord-010092-uftc8inx 10996 15 , , , cord-010092-uftc8inx 10996 16 and and CC cord-010092-uftc8inx 10996 17 was be VBD cord-010092-uftc8inx 10996 18 discharged discharge VBN cord-010092-uftc8inx 10996 19 with with IN cord-010092-uftc8inx 10996 20 SpO2 SpO2 NNP cord-010092-uftc8inx 10996 21 of of IN cord-010092-uftc8inx 10996 22 97 97 CD cord-010092-uftc8inx 10996 23 % % NN cord-010092-uftc8inx 10996 24 on on IN cord-010092-uftc8inx 10996 25 air air NN cord-010092-uftc8inx 10996 26 . . . cord-010092-uftc8inx 10997 1 Summary Summary NNP cord-010092-uftc8inx 10997 2 / / SYM cord-010092-uftc8inx 10997 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 10997 4 : : : cord-010092-uftc8inx 10998 1 Automated Automated NNP cord-010092-uftc8inx 10998 2 RBC RBC NNP cord-010092-uftc8inx 10998 3 exchange exchange NN cord-010092-uftc8inx 10998 4 can can MD cord-010092-uftc8inx 10998 5 be be VB cord-010092-uftc8inx 10998 6 used use VBN cord-010092-uftc8inx 10998 7 in in IN cord-010092-uftc8inx 10998 8 patients patient NNS cord-010092-uftc8inx 10998 9 of of IN cord-010092-uftc8inx 10998 10 acquired acquire VBN cord-010092-uftc8inx 10998 11 methemoglobinemia methemoglobinemia NN cord-010092-uftc8inx 10998 12 successfully successfully RB cord-010092-uftc8inx 10998 13 when when WRB cord-010092-uftc8inx 10998 14 methylene methylene NN cord-010092-uftc8inx 10998 15 blue blue NN cord-010092-uftc8inx 10998 16 is be VBZ cord-010092-uftc8inx 10998 17 ineffective ineffective JJ cord-010092-uftc8inx 10998 18 , , , cord-010092-uftc8inx 10998 19 and and CC cord-010092-uftc8inx 10998 20 may may MD cord-010092-uftc8inx 10998 21 be be VB cord-010092-uftc8inx 10998 22 superior superior JJ cord-010092-uftc8inx 10998 23 to to IN cord-010092-uftc8inx 10998 24 manual manual JJ cord-010092-uftc8inx 10998 25 one one CD cord-010092-uftc8inx 10998 26 . . . cord-010092-uftc8inx 10999 1 Background background NN cord-010092-uftc8inx 10999 2 : : : cord-010092-uftc8inx 11000 1 Therapeutic therapeutic JJ cord-010092-uftc8inx 11000 2 plasma plasma NN cord-010092-uftc8inx 11000 3 exchange exchange NN cord-010092-uftc8inx 11000 4 ( ( -LRB- cord-010092-uftc8inx 11000 5 TPE TPE NNP cord-010092-uftc8inx 11000 6 ) ) -RRB- cord-010092-uftc8inx 11000 7 is be VBZ cord-010092-uftc8inx 11000 8 known know VBN cord-010092-uftc8inx 11000 9 to to TO cord-010092-uftc8inx 11000 10 disturb disturb VB cord-010092-uftc8inx 11000 11 the the DT cord-010092-uftc8inx 11000 12 pH ph NN cord-010092-uftc8inx 11000 13 and and CC cord-010092-uftc8inx 11000 14 electrolyte electrolyte JJ cord-010092-uftc8inx 11000 15 status status NN cord-010092-uftc8inx 11000 16 . . . cord-010092-uftc8inx 11001 1 Patients patient NNS cord-010092-uftc8inx 11001 2 with with IN cord-010092-uftc8inx 11001 3 compromised compromised JJ cord-010092-uftc8inx 11001 4 liver liver NN cord-010092-uftc8inx 11001 5 functions function NNS cord-010092-uftc8inx 11001 6 may may MD cord-010092-uftc8inx 11001 7 be be VB cord-010092-uftc8inx 11001 8 at at IN cord-010092-uftc8inx 11001 9 a a DT cord-010092-uftc8inx 11001 10 higher high JJR cord-010092-uftc8inx 11001 11 risk risk NN cord-010092-uftc8inx 11001 12 of of IN cord-010092-uftc8inx 11001 13 electrolyte electrolyte JJ cord-010092-uftc8inx 11001 14 imbalance imbalance NN cord-010092-uftc8inx 11001 15 due due IN cord-010092-uftc8inx 11001 16 to to IN cord-010092-uftc8inx 11001 17 metabolic metabolic JJ cord-010092-uftc8inx 11001 18 abnormalities abnormality NNS cord-010092-uftc8inx 11001 19 . . . cord-010092-uftc8inx 11002 1 Aims aim VBZ cord-010092-uftc8inx 11002 2 : : : cord-010092-uftc8inx 11003 1 The the DT cord-010092-uftc8inx 11003 2 aim aim NN cord-010092-uftc8inx 11003 3 of of IN cord-010092-uftc8inx 11003 4 this this DT cord-010092-uftc8inx 11003 5 study study NN cord-010092-uftc8inx 11003 6 was be VBD cord-010092-uftc8inx 11003 7 to to TO cord-010092-uftc8inx 11003 8 analyze analyze VB cord-010092-uftc8inx 11003 9 the the DT cord-010092-uftc8inx 11003 10 variation variation NN cord-010092-uftc8inx 11003 11 in in IN cord-010092-uftc8inx 11003 12 pH pH NNP cord-010092-uftc8inx 11003 13 , , , cord-010092-uftc8inx 11003 14 ionized ionized JJ cord-010092-uftc8inx 11003 15 calcium calcium NN cord-010092-uftc8inx 11003 16 , , , cord-010092-uftc8inx 11003 17 sodium sodium NN cord-010092-uftc8inx 11003 18 , , , cord-010092-uftc8inx 11003 19 potassium potassium NN cord-010092-uftc8inx 11003 20 , , , cord-010092-uftc8inx 11003 21 and and CC cord-010092-uftc8inx 11003 22 bicarbonate bicarbonate NN cord-010092-uftc8inx 11003 23 in in IN cord-010092-uftc8inx 11003 24 liver liver NN cord-010092-uftc8inx 11003 25 disease disease NN cord-010092-uftc8inx 11003 26 patients patient NNS cord-010092-uftc8inx 11003 27 undergoing undergo VBG cord-010092-uftc8inx 11003 28 TPE TPE NNP cord-010092-uftc8inx 11003 29 . . . cord-010092-uftc8inx 11004 1 Methods method NNS cord-010092-uftc8inx 11004 2 : : : cord-010092-uftc8inx 11004 3 Patients patient NNS cord-010092-uftc8inx 11004 4 with with IN cord-010092-uftc8inx 11004 5 liver liver NN cord-010092-uftc8inx 11004 6 disease disease NN cord-010092-uftc8inx 11004 7 undergoing undergo VBG cord-010092-uftc8inx 11004 8 TPE TPE NNP cord-010092-uftc8inx 11004 9 during during IN cord-010092-uftc8inx 11004 10 the the DT cord-010092-uftc8inx 11004 11 period period NN cord-010092-uftc8inx 11004 12 from from IN cord-010092-uftc8inx 11004 13 July July NNP cord-010092-uftc8inx 11004 14 2016 2016 CD cord-010092-uftc8inx 11004 15 to to IN cord-010092-uftc8inx 11004 16 August August NNP cord-010092-uftc8inx 11004 17 2017 2017 CD cord-010092-uftc8inx 11004 18 were be VBD cord-010092-uftc8inx 11004 19 included include VBN cord-010092-uftc8inx 11004 20 in in IN cord-010092-uftc8inx 11004 21 the the DT cord-010092-uftc8inx 11004 22 study study NN cord-010092-uftc8inx 11004 23 . . . cord-010092-uftc8inx 11005 1 Data datum NNS cord-010092-uftc8inx 11005 2 on on IN cord-010092-uftc8inx 11005 3 patient patient JJ cord-010092-uftc8inx 11005 4 demographics demographic NNS cord-010092-uftc8inx 11005 5 , , , cord-010092-uftc8inx 11005 6 details detail NNS cord-010092-uftc8inx 11005 7 of of IN cord-010092-uftc8inx 11005 8 the the DT cord-010092-uftc8inx 11005 9 TPE TPE NNP cord-010092-uftc8inx 11005 10 procedure procedure NN cord-010092-uftc8inx 11005 11 , , , cord-010092-uftc8inx 11005 12 blood blood NN cord-010092-uftc8inx 11005 13 gas gas NN cord-010092-uftc8inx 11005 14 analysis analysis NN cord-010092-uftc8inx 11005 15 report report NN cord-010092-uftc8inx 11005 16 and and CC cord-010092-uftc8inx 11005 17 adverse adverse JJ cord-010092-uftc8inx 11005 18 effects effect NNS cord-010092-uftc8inx 11005 19 of of IN cord-010092-uftc8inx 11005 20 TPE TPE NNP cord-010092-uftc8inx 11005 21 ( ( -LRB- cord-010092-uftc8inx 11005 22 if if IN cord-010092-uftc8inx 11005 23 any any DT cord-010092-uftc8inx 11005 24 ) ) -RRB- cord-010092-uftc8inx 11005 25 were be VBD cord-010092-uftc8inx 11005 26 collected collect VBN cord-010092-uftc8inx 11005 27 and and CC cord-010092-uftc8inx 11005 28 analyzed analyze VBN cord-010092-uftc8inx 11005 29 . . . cord-010092-uftc8inx 11006 1 Results result NNS cord-010092-uftc8inx 11006 2 : : : cord-010092-uftc8inx 11007 1 One one CD cord-010092-uftc8inx 11007 2 hundred hundred CD cord-010092-uftc8inx 11007 3 and and CC cord-010092-uftc8inx 11007 4 seven seven CD cord-010092-uftc8inx 11007 5 procedures procedure NNS cord-010092-uftc8inx 11007 6 were be VBD cord-010092-uftc8inx 11007 7 done do VBN cord-010092-uftc8inx 11007 8 during during IN cord-010092-uftc8inx 11007 9 the the DT cord-010092-uftc8inx 11007 10 study study NN cord-010092-uftc8inx 11007 11 period period NN cord-010092-uftc8inx 11007 12 ; ; : cord-010092-uftc8inx 11007 13 of of IN cord-010092-uftc8inx 11007 14 these these DT cord-010092-uftc8inx 11007 15 46 46 CD cord-010092-uftc8inx 11007 16 ( ( -LRB- cord-010092-uftc8inx 11007 17 43 43 CD cord-010092-uftc8inx 11007 18 % % NN cord-010092-uftc8inx 11007 19 ) ) -RRB- cord-010092-uftc8inx 11007 20 were be VBD cord-010092-uftc8inx 11007 21 done do VBN cord-010092-uftc8inx 11007 22 on on IN cord-010092-uftc8inx 11007 23 the the DT cord-010092-uftc8inx 11007 24 MCS MCS NNP cord-010092-uftc8inx 11007 25 plus plus CC cord-010092-uftc8inx 11007 26 ( ( -LRB- cord-010092-uftc8inx 11007 27 Haemonetics Haemonetics NNP cord-010092-uftc8inx 11007 28 Corporation Corporation NNP cord-010092-uftc8inx 11007 29 ) ) -RRB- cord-010092-uftc8inx 11007 30 and and CC cord-010092-uftc8inx 11007 31 rest rest VB cord-010092-uftc8inx 11007 32 61 61 CD cord-010092-uftc8inx 11007 33 ( ( -LRB- cord-010092-uftc8inx 11007 34 57 57 CD cord-010092-uftc8inx 11007 35 % % NN cord-010092-uftc8inx 11007 36 ) ) -RRB- cord-010092-uftc8inx 11008 1 were be VBD cord-010092-uftc8inx 11008 2 done do VBN cord-010092-uftc8inx 11008 3 on on IN cord-010092-uftc8inx 11008 4 the the DT cord-010092-uftc8inx 11008 5 Spectra Spectra NNP cord-010092-uftc8inx 11008 6 Optia Optia NNP cord-010092-uftc8inx 11008 7 ( ( -LRB- cord-010092-uftc8inx 11008 8 Terumo Terumo NNP cord-010092-uftc8inx 11008 9 BCT BCT NNP cord-010092-uftc8inx 11008 10 ) ) -RRB- cord-010092-uftc8inx 11008 11 . . . cord-010092-uftc8inx 11009 1 The the DT cord-010092-uftc8inx 11009 2 percentage percentage NN cord-010092-uftc8inx 11009 3 change change NN cord-010092-uftc8inx 11009 4 in in IN cord-010092-uftc8inx 11009 5 ionized ionized JJ cord-010092-uftc8inx 11009 6 calcium calcium NN cord-010092-uftc8inx 11009 7 , , , cord-010092-uftc8inx 11009 8 sodium sodium NN cord-010092-uftc8inx 11009 9 , , , cord-010092-uftc8inx 11009 10 and and CC cord-010092-uftc8inx 11009 11 potassium potassium NN cord-010092-uftc8inx 11009 12 due due IN cord-010092-uftc8inx 11009 13 to to IN cord-010092-uftc8inx 11009 14 the the DT cord-010092-uftc8inx 11009 15 procedure procedure NN cord-010092-uftc8inx 11009 16 was be VBD cord-010092-uftc8inx 11009 17 found find VBN cord-010092-uftc8inx 11009 18 to to TO cord-010092-uftc8inx 11009 19 be be VB cord-010092-uftc8inx 11009 20 statistically statistically RB cord-010092-uftc8inx 11009 21 significant significant JJ cord-010092-uftc8inx 11009 22 ( ( -LRB- cord-010092-uftc8inx 11009 23 P p NN cord-010092-uftc8inx 11009 24 = = SYM cord-010092-uftc8inx 11009 25 0.000 0.000 CD cord-010092-uftc8inx 11009 26 ) ) -RRB- cord-010092-uftc8inx 11009 27 . . . cord-010092-uftc8inx 11010 1 The the DT cord-010092-uftc8inx 11010 2 systolic systolic JJ cord-010092-uftc8inx 11010 3 ( ( -LRB- cord-010092-uftc8inx 11010 4 P p NN cord-010092-uftc8inx 11010 5 = = SYM cord-010092-uftc8inx 11010 6 0.010 0.010 CD cord-010092-uftc8inx 11010 7 ) ) -RRB- cord-010092-uftc8inx 11010 8 and and CC cord-010092-uftc8inx 11010 9 diastolic diastolic JJ cord-010092-uftc8inx 11010 10 ( ( -LRB- cord-010092-uftc8inx 11010 11 0.001 0.001 CD cord-010092-uftc8inx 11010 12 ) ) -RRB- cord-010092-uftc8inx 11010 13 blood blood NN cord-010092-uftc8inx 11010 14 pressure pressure NN cord-010092-uftc8inx 11010 15 also also RB cord-010092-uftc8inx 11010 16 changed change VBD cord-010092-uftc8inx 11010 17 significantly significantly RB cord-010092-uftc8inx 11010 18 with with IN cord-010092-uftc8inx 11010 19 the the DT cord-010092-uftc8inx 11010 20 procedure procedure NN cord-010092-uftc8inx 11010 21 . . . cord-010092-uftc8inx 11011 1 The the DT cord-010092-uftc8inx 11011 2 predictors predictor NNS cord-010092-uftc8inx 11011 3 for for IN cord-010092-uftc8inx 11011 4 the the DT cord-010092-uftc8inx 11011 5 change change NN cord-010092-uftc8inx 11011 6 in in IN cord-010092-uftc8inx 11011 7 ionized ionized JJ cord-010092-uftc8inx 11011 8 calcium calcium NN cord-010092-uftc8inx 11011 9 were be VBD cord-010092-uftc8inx 11011 10 found find VBN cord-010092-uftc8inx 11011 11 to to TO cord-010092-uftc8inx 11011 12 be be VB cord-010092-uftc8inx 11011 13 pre pre JJ cord-010092-uftc8inx 11011 14 - - JJ cord-010092-uftc8inx 11011 15 procedure procedure JJ cord-010092-uftc8inx 11011 16 ionized ionized JJ cord-010092-uftc8inx 11011 17 calcium calcium NN cord-010092-uftc8inx 11011 18 ( ( -LRB- cord-010092-uftc8inx 11011 19 P p NN cord-010092-uftc8inx 11011 20 < < XX cord-010092-uftc8inx 11011 21 0.001 0.001 CD cord-010092-uftc8inx 11011 22 ) ) -RRB- cord-010092-uftc8inx 11011 23 , , , cord-010092-uftc8inx 11011 24 the the DT cord-010092-uftc8inx 11011 25 age age NN cord-010092-uftc8inx 11011 26 of of IN cord-010092-uftc8inx 11011 27 the the DT cord-010092-uftc8inx 11011 28 patient patient NN cord-010092-uftc8inx 11011 29 ( ( -LRB- cord-010092-uftc8inx 11011 30 P p NN cord-010092-uftc8inx 11011 31 < < XX cord-010092-uftc8inx 11011 32 0.001 0.001 CD cord-010092-uftc8inx 11011 33 ) ) -RRB- cord-010092-uftc8inx 11011 34 and and CC cord-010092-uftc8inx 11011 35 the the DT cord-010092-uftc8inx 11011 36 pre pre JJ cord-010092-uftc8inx 11011 37 - - NN cord-010092-uftc8inx 11011 38 procedure procedure JJ cord-010092-uftc8inx 11011 39 pH ph NN cord-010092-uftc8inx 11011 40 ( ( -LRB- cord-010092-uftc8inx 11011 41 P p NN cord-010092-uftc8inx 11011 42 = = SYM cord-010092-uftc8inx 11011 43 0.002 0.002 CD cord-010092-uftc8inx 11011 44 ) ) -RRB- cord-010092-uftc8inx 11011 45 . . . cord-010092-uftc8inx 11012 1 Procedurerelated Procedurerelated NNP cord-010092-uftc8inx 11012 2 complications complication NNS cord-010092-uftc8inx 11012 3 occurred occur VBD cord-010092-uftc8inx 11012 4 during during IN cord-010092-uftc8inx 11012 5 30 30 CD cord-010092-uftc8inx 11012 6 procedures procedure NNS cord-010092-uftc8inx 11012 7 of of IN cord-010092-uftc8inx 11012 8 which which WDT cord-010092-uftc8inx 11012 9 13 13 CD cord-010092-uftc8inx 11012 10 complications complication NNS cord-010092-uftc8inx 11012 11 ( ( -LRB- cord-010092-uftc8inx 11012 12 12.15 12.15 CD cord-010092-uftc8inx 11012 13 % % NN cord-010092-uftc8inx 11012 14 ) ) -RRB- cord-010092-uftc8inx 11012 15 were be VBD cord-010092-uftc8inx 11012 16 categorized categorize VBN cord-010092-uftc8inx 11012 17 as as IN cord-010092-uftc8inx 11012 18 features feature NNS cord-010092-uftc8inx 11012 19 of of IN cord-010092-uftc8inx 11012 20 hypocalcemia hypocalcemia NN cord-010092-uftc8inx 11012 21 . . . cord-010092-uftc8inx 11013 1 No no DT cord-010092-uftc8inx 11013 2 association association NN cord-010092-uftc8inx 11013 3 was be VBD cord-010092-uftc8inx 11013 4 found find VBN cord-010092-uftc8inx 11013 5 between between IN cord-010092-uftc8inx 11013 6 hypocalcemic hypocalcemic JJ cord-010092-uftc8inx 11013 7 manifestations manifestation NNS cord-010092-uftc8inx 11013 8 and and CC cord-010092-uftc8inx 11013 9 pre pre JJ cord-010092-uftc8inx 11013 10 - - JJ cord-010092-uftc8inx 11013 11 procedure procedure JJ cord-010092-uftc8inx 11013 12 calcium calcium NN cord-010092-uftc8inx 11013 13 , , , cord-010092-uftc8inx 11013 14 change change NN cord-010092-uftc8inx 11013 15 in in IN cord-010092-uftc8inx 11013 16 calcium calcium NN cord-010092-uftc8inx 11013 17 , , , cord-010092-uftc8inx 11013 18 age age NN cord-010092-uftc8inx 11013 19 or or CC cord-010092-uftc8inx 11013 20 gender gender NN cord-010092-uftc8inx 11013 21 of of IN cord-010092-uftc8inx 11013 22 the the DT cord-010092-uftc8inx 11013 23 patient patient NN cord-010092-uftc8inx 11013 24 . . . cord-010092-uftc8inx 11014 1 Summary Summary NNP cord-010092-uftc8inx 11014 2 / / SYM cord-010092-uftc8inx 11014 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 11014 4 : : : cord-010092-uftc8inx 11015 1 The the DT cord-010092-uftc8inx 11015 2 TPE TPE NNP cord-010092-uftc8inx 11015 3 procedure procedure NN cord-010092-uftc8inx 11015 4 in in IN cord-010092-uftc8inx 11015 5 liver liver NN cord-010092-uftc8inx 11015 6 disease disease NN cord-010092-uftc8inx 11015 7 patients patient NNS cord-010092-uftc8inx 11015 8 causes cause VBZ cord-010092-uftc8inx 11015 9 remarkable remarkable JJ cord-010092-uftc8inx 11015 10 changes change NNS cord-010092-uftc8inx 11015 11 in in IN cord-010092-uftc8inx 11015 12 ionized ionized JJ cord-010092-uftc8inx 11015 13 calcium calcium NN cord-010092-uftc8inx 11015 14 , , , cord-010092-uftc8inx 11015 15 sodium sodium NN cord-010092-uftc8inx 11015 16 , , , cord-010092-uftc8inx 11015 17 potassium potassium NN cord-010092-uftc8inx 11015 18 and and CC cord-010092-uftc8inx 11015 19 bicarbonate bicarbonate NN cord-010092-uftc8inx 11015 20 ions ion NNS cord-010092-uftc8inx 11015 21 . . . cord-010092-uftc8inx 11016 1 The the DT cord-010092-uftc8inx 11016 2 decrease decrease NN cord-010092-uftc8inx 11016 3 in in IN cord-010092-uftc8inx 11016 4 ionized ionized JJ cord-010092-uftc8inx 11016 5 calcium calcium NN cord-010092-uftc8inx 11016 6 during during IN cord-010092-uftc8inx 11016 7 the the DT cord-010092-uftc8inx 11016 8 procedure procedure NN cord-010092-uftc8inx 11016 9 is be VBZ cord-010092-uftc8inx 11016 10 predicted predict VBN cord-010092-uftc8inx 11016 11 by by IN cord-010092-uftc8inx 11016 12 pre pre JJ cord-010092-uftc8inx 11016 13 - - JJ cord-010092-uftc8inx 11016 14 procedure procedure JJ cord-010092-uftc8inx 11016 15 ionized ionized JJ cord-010092-uftc8inx 11016 16 calcium calcium NN cord-010092-uftc8inx 11016 17 levels level NNS cord-010092-uftc8inx 11016 18 , , , cord-010092-uftc8inx 11016 19 pH ph NN cord-010092-uftc8inx 11016 20 and and CC cord-010092-uftc8inx 11016 21 age age NN cord-010092-uftc8inx 11016 22 of of IN cord-010092-uftc8inx 11016 23 the the DT cord-010092-uftc8inx 11016 24 patient patient NN cord-010092-uftc8inx 11016 25 . . . cord-010092-uftc8inx 11017 1 Monitoring monitor VBG cord-010092-uftc8inx 11017 2 of of IN cord-010092-uftc8inx 11017 3 these these DT cord-010092-uftc8inx 11017 4 parameters parameter NNS cord-010092-uftc8inx 11017 5 and and CC cord-010092-uftc8inx 11017 6 appropriate appropriate JJ cord-010092-uftc8inx 11017 7 corrective corrective JJ cord-010092-uftc8inx 11017 8 measures measure NNS cord-010092-uftc8inx 11017 9 are be VBP cord-010092-uftc8inx 11017 10 imperative imperative JJ cord-010092-uftc8inx 11017 11 to to IN cord-010092-uftc8inx 11017 12 patient patient JJ cord-010092-uftc8inx 11017 13 safety safety NN cord-010092-uftc8inx 11017 14 . . . cord-010092-uftc8inx 11018 1 Background background NN cord-010092-uftc8inx 11018 2 : : : cord-010092-uftc8inx 11019 1 Therapeutic therapeutic JJ cord-010092-uftc8inx 11019 2 plasma plasma NN cord-010092-uftc8inx 11019 3 exchange exchange NN cord-010092-uftc8inx 11019 4 ( ( -LRB- cord-010092-uftc8inx 11019 5 TPE TPE NNP cord-010092-uftc8inx 11019 6 ) ) -RRB- cord-010092-uftc8inx 11019 7 in in IN cord-010092-uftc8inx 11019 8 pediatric pediatric JJ cord-010092-uftc8inx 11019 9 age age NN cord-010092-uftc8inx 11019 10 group group NN cord-010092-uftc8inx 11019 11 is be VBZ cord-010092-uftc8inx 11019 12 technically technically RB cord-010092-uftc8inx 11019 13 demanding demanding JJ cord-010092-uftc8inx 11019 14 because because IN cord-010092-uftc8inx 11019 15 of of IN cord-010092-uftc8inx 11019 16 low low JJ cord-010092-uftc8inx 11019 17 blood blood NN cord-010092-uftc8inx 11019 18 volume volume NN cord-010092-uftc8inx 11019 19 , , , cord-010092-uftc8inx 11019 20 difficult difficult JJ cord-010092-uftc8inx 11019 21 venous venous JJ cord-010092-uftc8inx 11019 22 access access NN cord-010092-uftc8inx 11019 23 and and CC cord-010092-uftc8inx 11019 24 poor poor JJ cord-010092-uftc8inx 11019 25 cooperation cooperation NN cord-010092-uftc8inx 11019 26 of of IN cord-010092-uftc8inx 11019 27 the the DT cord-010092-uftc8inx 11019 28 patient patient NN cord-010092-uftc8inx 11019 29 during during IN cord-010092-uftc8inx 11019 30 the the DT cord-010092-uftc8inx 11019 31 procedure procedure NN cord-010092-uftc8inx 11019 32 . . . cord-010092-uftc8inx 11020 1 We -PRON- PRP cord-010092-uftc8inx 11020 2 here here RB cord-010092-uftc8inx 11020 3 present present VBP cord-010092-uftc8inx 11020 4 our -PRON- PRP$ cord-010092-uftc8inx 11020 5 experience experience NN cord-010092-uftc8inx 11020 6 of of IN cord-010092-uftc8inx 11020 7 TPE TPE NNP cord-010092-uftc8inx 11020 8 in in IN cord-010092-uftc8inx 11020 9 pediatric pediatric JJ cord-010092-uftc8inx 11020 10 patients patient NNS cord-010092-uftc8inx 11020 11 from from IN cord-010092-uftc8inx 11020 12 our -PRON- PRP$ cord-010092-uftc8inx 11020 13 centre centre NN cord-010092-uftc8inx 11020 14 . . . cord-010092-uftc8inx 11021 1 Aims aim VBZ cord-010092-uftc8inx 11021 2 : : : cord-010092-uftc8inx 11021 3 To to TO cord-010092-uftc8inx 11021 4 assess assess VB cord-010092-uftc8inx 11021 5 the the DT cord-010092-uftc8inx 11021 6 challenges challenge NNS cord-010092-uftc8inx 11021 7 during during IN cord-010092-uftc8inx 11021 8 TPE TPE NNP cord-010092-uftc8inx 11021 9 in in IN cord-010092-uftc8inx 11021 10 pediatric pediatric JJ cord-010092-uftc8inx 11021 11 patients patient NNS cord-010092-uftc8inx 11021 12 and and CC cord-010092-uftc8inx 11021 13 formulate formulate VB cord-010092-uftc8inx 11021 14 appropriate appropriate JJ cord-010092-uftc8inx 11021 15 strategies strategy NNS cord-010092-uftc8inx 11021 16 . . . cord-010092-uftc8inx 11022 1 Methods method NNS cord-010092-uftc8inx 11022 2 : : : cord-010092-uftc8inx 11022 3 We -PRON- PRP cord-010092-uftc8inx 11022 4 did do VBD cord-010092-uftc8inx 11022 5 retrospective retrospective JJ cord-010092-uftc8inx 11022 6 analysis analysis NN cord-010092-uftc8inx 11022 7 of of IN cord-010092-uftc8inx 11022 8 all all DT cord-010092-uftc8inx 11022 9 TPE TPE NNP cord-010092-uftc8inx 11022 10 procedures procedure NNS cord-010092-uftc8inx 11022 11 performed perform VBN cord-010092-uftc8inx 11022 12 in in IN cord-010092-uftc8inx 11022 13 pediatric pediatric JJ cord-010092-uftc8inx 11022 14 patients patient NNS cord-010092-uftc8inx 11022 15 over over IN cord-010092-uftc8inx 11022 16 a a DT cord-010092-uftc8inx 11022 17 period period NN cord-010092-uftc8inx 11022 18 of of IN cord-010092-uftc8inx 11022 19 16 16 CD cord-010092-uftc8inx 11022 20 years year NNS cord-010092-uftc8inx 11022 21 ( ( -LRB- cord-010092-uftc8inx 11022 22 2001 2001 CD cord-010092-uftc8inx 11022 23 ) ) -RRB- cord-010092-uftc8inx 11022 24 ( ( -LRB- cord-010092-uftc8inx 11022 25 2002 2002 CD cord-010092-uftc8inx 11022 26 ) ) -RRB- cord-010092-uftc8inx 11022 27 ( ( -LRB- cord-010092-uftc8inx 11022 28 2003 2003 CD cord-010092-uftc8inx 11022 29 ) ) -RRB- cord-010092-uftc8inx 11022 30 ( ( -LRB- cord-010092-uftc8inx 11022 31 2004 2004 CD cord-010092-uftc8inx 11022 32 ) ) -RRB- cord-010092-uftc8inx 11022 33 ( ( -LRB- cord-010092-uftc8inx 11022 34 2005 2005 CD cord-010092-uftc8inx 11022 35 ) ) -RRB- cord-010092-uftc8inx 11022 36 ( ( -LRB- cord-010092-uftc8inx 11022 37 2006 2006 CD cord-010092-uftc8inx 11022 38 ) ) -RRB- cord-010092-uftc8inx 11022 39 ( ( -LRB- cord-010092-uftc8inx 11022 40 2007 2007 CD cord-010092-uftc8inx 11022 41 ) ) -RRB- cord-010092-uftc8inx 11022 42 ( ( -LRB- cord-010092-uftc8inx 11022 43 2008 2008 CD cord-010092-uftc8inx 11022 44 ) ) -RRB- cord-010092-uftc8inx 11022 45 ( ( -LRB- cord-010092-uftc8inx 11022 46 2009 2009 CD cord-010092-uftc8inx 11022 47 ) ) -RRB- cord-010092-uftc8inx 11022 48 ( ( -LRB- cord-010092-uftc8inx 11022 49 2010 2010 CD cord-010092-uftc8inx 11022 50 ) ) -RRB- cord-010092-uftc8inx 11022 51 ( ( -LRB- cord-010092-uftc8inx 11022 52 2011 2011 CD cord-010092-uftc8inx 11022 53 ) ) -RRB- cord-010092-uftc8inx 11022 54 ( ( -LRB- cord-010092-uftc8inx 11022 55 2012 2012 CD cord-010092-uftc8inx 11022 56 ) ) -RRB- cord-010092-uftc8inx 11022 57 ( ( -LRB- cord-010092-uftc8inx 11022 58 2013 2013 CD cord-010092-uftc8inx 11022 59 ) ) -RRB- cord-010092-uftc8inx 11022 60 ( ( -LRB- cord-010092-uftc8inx 11022 61 2014 2014 CD cord-010092-uftc8inx 11022 62 ) ) -RRB- cord-010092-uftc8inx 11022 63 ( ( -LRB- cord-010092-uftc8inx 11022 64 2015 2015 CD cord-010092-uftc8inx 11022 65 ) ) -RRB- cord-010092-uftc8inx 11022 66 ( ( -LRB- cord-010092-uftc8inx 11022 67 2016 2016 CD cord-010092-uftc8inx 11022 68 ) ) -RRB- cord-010092-uftc8inx 11022 69 . . . cord-010092-uftc8inx 11023 1 TPE TPE NNP cord-010092-uftc8inx 11023 2 procedures procedure NNS cord-010092-uftc8inx 11023 3 were be VBD cord-010092-uftc8inx 11023 4 done do VBN cord-010092-uftc8inx 11023 5 on on IN cord-010092-uftc8inx 11023 6 two two CD cord-010092-uftc8inx 11023 7 different different JJ cord-010092-uftc8inx 11023 8 apheretic apheretic JJ cord-010092-uftc8inx 11023 9 devices device NNS cord-010092-uftc8inx 11023 10 ( ( -LRB- cord-010092-uftc8inx 11023 11 CS CS NNP cord-010092-uftc8inx 11023 12 3000 3000 CD cord-010092-uftc8inx 11023 13 plus plus CC cord-010092-uftc8inx 11023 14 , , , cord-010092-uftc8inx 11023 15 Fenwal Fenwal NNP cord-010092-uftc8inx 11023 16 USA USA NNP cord-010092-uftc8inx 11023 17 and and CC cord-010092-uftc8inx 11023 18 Cobe Cobe NNP cord-010092-uftc8inx 11023 19 spectra spectrum NNS cord-010092-uftc8inx 11023 20 , , , cord-010092-uftc8inx 11023 21 Terumo Terumo NNP cord-010092-uftc8inx 11023 22 BCT BCT NNP cord-010092-uftc8inx 11023 23 Lakewood Lakewood NNP cord-010092-uftc8inx 11023 24 , , , cord-010092-uftc8inx 11023 25 Colorado Colorado NNP cord-010092-uftc8inx 11023 26 ) ) -RRB- cord-010092-uftc8inx 11023 27 daily daily RB cord-010092-uftc8inx 11023 28 or or CC cord-010092-uftc8inx 11023 29 on on IN cord-010092-uftc8inx 11023 30 alternate alternate JJ cord-010092-uftc8inx 11023 31 days day NNS cord-010092-uftc8inx 11023 32 depending depend VBG cord-010092-uftc8inx 11023 33 on on IN cord-010092-uftc8inx 11023 34 clinical clinical JJ cord-010092-uftc8inx 11023 35 condition condition NN cord-010092-uftc8inx 11023 36 of of IN cord-010092-uftc8inx 11023 37 the the DT cord-010092-uftc8inx 11023 38 patient patient NN cord-010092-uftc8inx 11023 39 . . . cord-010092-uftc8inx 11024 1 For for IN cord-010092-uftc8inx 11024 2 all all DT cord-010092-uftc8inx 11024 3 procedures procedure NNS cord-010092-uftc8inx 11024 4 , , , cord-010092-uftc8inx 11024 5 kit kit NN cord-010092-uftc8inx 11024 6 was be VBD cord-010092-uftc8inx 11024 7 primed prime VBN cord-010092-uftc8inx 11024 8 with with IN cord-010092-uftc8inx 11024 9 compatible compatible JJ cord-010092-uftc8inx 11024 10 packed packed JJ cord-010092-uftc8inx 11024 11 red red JJ cord-010092-uftc8inx 11024 12 cells cell NNS cord-010092-uftc8inx 11024 13 . . . cord-010092-uftc8inx 11025 1 Adverse adverse JJ cord-010092-uftc8inx 11025 2 events event NNS cord-010092-uftc8inx 11025 3 during during IN cord-010092-uftc8inx 11025 4 the the DT cord-010092-uftc8inx 11025 5 procedure procedure NN cord-010092-uftc8inx 11025 6 were be VBD cord-010092-uftc8inx 11025 7 noted note VBN cord-010092-uftc8inx 11025 8 and and CC cord-010092-uftc8inx 11025 9 analyzed analyze VBN cord-010092-uftc8inx 11025 10 . . . cord-010092-uftc8inx 11026 1 Results result NNS cord-010092-uftc8inx 11026 2 : : : cord-010092-uftc8inx 11027 1 A a DT cord-010092-uftc8inx 11027 2 total total NN cord-010092-uftc8inx 11027 3 of of IN cord-010092-uftc8inx 11027 4 356 356 CD cord-010092-uftc8inx 11027 5 TPE TPE NNP cord-010092-uftc8inx 11027 6 ( ( -LRB- cord-010092-uftc8inx 11027 7 range range NNP cord-010092-uftc8inx 11027 8 1 1 CD cord-010092-uftc8inx 11027 9 - - HYPH cord-010092-uftc8inx 11027 10 22 22 CD cord-010092-uftc8inx 11027 11 / / SYM cord-010092-uftc8inx 11027 12 patient patient NN cord-010092-uftc8inx 11027 13 with with IN cord-010092-uftc8inx 11027 14 mean mean NN cord-010092-uftc8inx 11027 15 of of IN cord-010092-uftc8inx 11027 16 6.2 6.2 CD cord-010092-uftc8inx 11027 17 procedures procedure NNS cord-010092-uftc8inx 11027 18 ) ) -RRB- cord-010092-uftc8inx 11027 19 were be VBD cord-010092-uftc8inx 11027 20 performed perform VBN cord-010092-uftc8inx 11027 21 for for IN cord-010092-uftc8inx 11027 22 55 55 CD cord-010092-uftc8inx 11027 23 pediatric pediatric JJ cord-010092-uftc8inx 11027 24 patients patient NNS cord-010092-uftc8inx 11027 25 with with IN cord-010092-uftc8inx 11027 26 different different JJ cord-010092-uftc8inx 11027 27 indications indication NNS cord-010092-uftc8inx 11027 28 like like IN cord-010092-uftc8inx 11027 29 atypical atypical JJ cord-010092-uftc8inx 11027 30 HUS hus NN cord-010092-uftc8inx 11027 31 ( ( -LRB- cord-010092-uftc8inx 11027 32 category category NN cord-010092-uftc8inx 11027 33 I -PRON- PRP cord-010092-uftc8inx 11027 34 as as IN cord-010092-uftc8inx 11027 35 per per IN cord-010092-uftc8inx 11027 36 American American NNP cord-010092-uftc8inx 11027 37 Society Society NNP cord-010092-uftc8inx 11027 38 for for IN cord-010092-uftc8inx 11027 39 Apheresis Apheresis NNP cord-010092-uftc8inx 11027 40 ( ( -LRB- cord-010092-uftc8inx 11027 41 ASFA ASFA NNP cord-010092-uftc8inx 11027 42 ) ) -RRB- cord-010092-uftc8inx 11027 43 in in IN cord-010092-uftc8inx 11027 44 total total JJ cord-010092-uftc8inx 11027 45 44 44 CD cord-010092-uftc8inx 11027 46 patients patient NNS cord-010092-uftc8inx 11027 47 , , , cord-010092-uftc8inx 11027 48 Neuromyelitis Neuromyelitis NNP cord-010092-uftc8inx 11027 49 optica optica NN cord-010092-uftc8inx 11027 50 ( ( -LRB- cord-010092-uftc8inx 11027 51 category category NN cord-010092-uftc8inx 11027 52 II II NNP cord-010092-uftc8inx 11027 53 ) ) -RRB- cord-010092-uftc8inx 11027 54 in in IN cord-010092-uftc8inx 11027 55 4 4 CD cord-010092-uftc8inx 11027 56 patients patient NNS cord-010092-uftc8inx 11027 57 , , , cord-010092-uftc8inx 11027 58 Rapid Rapid NNP cord-010092-uftc8inx 11027 59 proliferative proliferative JJ cord-010092-uftc8inx 11027 60 glomerulonephritis glomerulonephritis NN cord-010092-uftc8inx 11027 61 ( ( -LRB- cord-010092-uftc8inx 11027 62 category category NN cord-010092-uftc8inx 11027 63 I I NNP cord-010092-uftc8inx 11027 64 ) ) -RRB- cord-010092-uftc8inx 11027 65 , , , cord-010092-uftc8inx 11027 66 C3 C3 NNP cord-010092-uftc8inx 11027 67 glomerulopathy glomerulopathy NN cord-010092-uftc8inx 11027 68 in in IN cord-010092-uftc8inx 11027 69 3 3 CD cord-010092-uftc8inx 11027 70 patients patient NNS cord-010092-uftc8inx 11027 71 each each DT cord-010092-uftc8inx 11027 72 and and CC cord-010092-uftc8inx 11027 73 one one CD cord-010092-uftc8inx 11027 74 patient patient NN cord-010092-uftc8inx 11027 75 of of IN cord-010092-uftc8inx 11027 76 infective infective JJ cord-010092-uftc8inx 11027 77 hemophagocytosis hemophagocytosis NN cord-010092-uftc8inx 11027 78 . . . cord-010092-uftc8inx 11028 1 The the DT cord-010092-uftc8inx 11028 2 average average JJ cord-010092-uftc8inx 11028 3 age age NN cord-010092-uftc8inx 11028 4 of of IN cord-010092-uftc8inx 11028 5 patient patient JJ cord-010092-uftc8inx 11028 6 population population NN cord-010092-uftc8inx 11028 7 was be VBD cord-010092-uftc8inx 11028 8 7.8 7.8 CD cord-010092-uftc8inx 11028 9 yrs yr NNS cord-010092-uftc8inx 11028 10 ( ( -LRB- cord-010092-uftc8inx 11028 11 1.2 1.2 CD cord-010092-uftc8inx 11028 12 - - SYM cord-010092-uftc8inx 11028 13 13 13 CD cord-010092-uftc8inx 11028 14 years year NNS cord-010092-uftc8inx 11028 15 ) ) -RRB- cord-010092-uftc8inx 11028 16 . . . cord-010092-uftc8inx 11029 1 The the DT cord-010092-uftc8inx 11029 2 Male male JJ cord-010092-uftc8inx 11029 3 : : : cord-010092-uftc8inx 11029 4 Female female JJ cord-010092-uftc8inx 11029 5 ratio ratio NN cord-010092-uftc8inx 11029 6 was be VBD cord-010092-uftc8inx 11029 7 3:1 3:1 CD cord-010092-uftc8inx 11029 8 with with IN cord-010092-uftc8inx 11029 9 an an DT cord-010092-uftc8inx 11029 10 average average JJ cord-010092-uftc8inx 11029 11 weight weight NN cord-010092-uftc8inx 11029 12 of of IN cord-010092-uftc8inx 11029 13 25.5 25.5 CD cord-010092-uftc8inx 11029 14 Kgs kg NNS cord-010092-uftc8inx 11029 15 . . . cord-010092-uftc8inx 11030 1 Adverse adverse JJ cord-010092-uftc8inx 11030 2 events event NNS cord-010092-uftc8inx 11030 3 were be VBD cord-010092-uftc8inx 11030 4 observed observe VBN cord-010092-uftc8inx 11030 5 during during IN cord-010092-uftc8inx 11030 6 20 20 CD cord-010092-uftc8inx 11030 7 ( ( -LRB- cord-010092-uftc8inx 11030 8 5.61 5.61 CD cord-010092-uftc8inx 11030 9 % % NN cord-010092-uftc8inx 11030 10 ) ) -RRB- cord-010092-uftc8inx 11030 11 procedures procedure NNS cord-010092-uftc8inx 11030 12 . . . cord-010092-uftc8inx 11031 1 Most most RBS cord-010092-uftc8inx 11031 2 commonly commonly RB cord-010092-uftc8inx 11031 3 observed observe VBD cord-010092-uftc8inx 11031 4 adverse adverse JJ cord-010092-uftc8inx 11031 5 events event NNS cord-010092-uftc8inx 11031 6 were be VBD cord-010092-uftc8inx 11031 7 allergic allergic JJ cord-010092-uftc8inx 11031 8 reaction reaction NN cord-010092-uftc8inx 11031 9 to to IN cord-010092-uftc8inx 11031 10 replacement replacement NN cord-010092-uftc8inx 11031 11 fluid fluid NN cord-010092-uftc8inx 11031 12 ( ( -LRB- cord-010092-uftc8inx 11031 13 1.4 1.4 CD cord-010092-uftc8inx 11031 14 % % NN cord-010092-uftc8inx 11031 15 ) ) -RRB- cord-010092-uftc8inx 11031 16 followed follow VBN cord-010092-uftc8inx 11031 17 by by IN cord-010092-uftc8inx 11031 18 hypotension hypotension NN cord-010092-uftc8inx 11031 19 ( ( -LRB- cord-010092-uftc8inx 11031 20 1.1 1.1 CD cord-010092-uftc8inx 11031 21 % % NN cord-010092-uftc8inx 11031 22 ) ) -RRB- cord-010092-uftc8inx 11031 23 , , , cord-010092-uftc8inx 11031 24 line line NN cord-010092-uftc8inx 11031 25 occlusion occlusion NN cord-010092-uftc8inx 11031 26 ( ( -LRB- cord-010092-uftc8inx 11031 27 0.8 0.8 CD cord-010092-uftc8inx 11031 28 % % NN cord-010092-uftc8inx 11031 29 ) ) -RRB- cord-010092-uftc8inx 11031 30 , , , cord-010092-uftc8inx 11031 31 vasovagal vasovagal NN cord-010092-uftc8inx 11031 32 , , , cord-010092-uftc8inx 11031 33 endotracheal endotracheal NN cord-010092-uftc8inx 11031 34 tube tube NN cord-010092-uftc8inx 11031 35 blockage blockage NN cord-010092-uftc8inx 11031 36 and and CC cord-010092-uftc8inx 11031 37 symptomatic symptomatic JJ cord-010092-uftc8inx 11031 38 hypocalcemia hypocalcemia NN cord-010092-uftc8inx 11031 39 was be VBD cord-010092-uftc8inx 11031 40 observed observe VBN cord-010092-uftc8inx 11031 41 in in IN cord-010092-uftc8inx 11031 42 one one CD cord-010092-uftc8inx 11031 43 procedure procedure NN cord-010092-uftc8inx 11031 44 each each DT cord-010092-uftc8inx 11032 1 ( ( -LRB- cord-010092-uftc8inx 11032 2 0.28%).There 0.28%).there CD cord-010092-uftc8inx 11032 3 was be VBD cord-010092-uftc8inx 11032 4 no no DT cord-010092-uftc8inx 11032 5 corelation corelation NN cord-010092-uftc8inx 11032 6 observed observe VBN cord-010092-uftc8inx 11032 7 between between IN cord-010092-uftc8inx 11032 8 physical physical JJ cord-010092-uftc8inx 11032 9 parameters parameter NNS cord-010092-uftc8inx 11032 10 of of IN cord-010092-uftc8inx 11032 11 patient patient NN cord-010092-uftc8inx 11032 12 with with IN cord-010092-uftc8inx 11032 13 adverse adverse JJ cord-010092-uftc8inx 11032 14 events event NNS cord-010092-uftc8inx 11032 15 . . . cord-010092-uftc8inx 11033 1 All all DT cord-010092-uftc8inx 11033 2 adverse adverse JJ cord-010092-uftc8inx 11033 3 events event NNS cord-010092-uftc8inx 11033 4 were be VBD cord-010092-uftc8inx 11033 5 managed manage VBN cord-010092-uftc8inx 11033 6 as as IN cord-010092-uftc8inx 11033 7 per per IN cord-010092-uftc8inx 11033 8 departmental departmental JJ cord-010092-uftc8inx 11033 9 standard standard JJ cord-010092-uftc8inx 11033 10 operating operating NN cord-010092-uftc8inx 11033 11 procedures procedure NNS cord-010092-uftc8inx 11033 12 ( ( -LRB- cord-010092-uftc8inx 11033 13 SOPs sop NNS cord-010092-uftc8inx 11033 14 ) ) -RRB- cord-010092-uftc8inx 11033 15 and and CC cord-010092-uftc8inx 11033 16 procedures procedure NNS cord-010092-uftc8inx 11033 17 were be VBD cord-010092-uftc8inx 11033 18 completed complete VBN cord-010092-uftc8inx 11033 19 successfully successfully RB cord-010092-uftc8inx 11033 20 except except IN cord-010092-uftc8inx 11033 21 in in IN cord-010092-uftc8inx 11033 22 one one CD cord-010092-uftc8inx 11033 23 where where WRB cord-010092-uftc8inx 11033 24 the the DT cord-010092-uftc8inx 11033 25 procedure procedure NN cord-010092-uftc8inx 11033 26 was be VBD cord-010092-uftc8inx 11033 27 abandoned abandon VBN cord-010092-uftc8inx 11033 28 . . . cord-010092-uftc8inx 11034 1 No no DT cord-010092-uftc8inx 11034 2 mortality mortality NN cord-010092-uftc8inx 11034 3 was be VBD cord-010092-uftc8inx 11034 4 observed observe VBN cord-010092-uftc8inx 11034 5 during during IN cord-010092-uftc8inx 11034 6 the the DT cord-010092-uftc8inx 11034 7 procedures procedure NNS cord-010092-uftc8inx 11034 8 . . . cord-010092-uftc8inx 11035 1 Background background NN cord-010092-uftc8inx 11035 2 : : : cord-010092-uftc8inx 11036 1 The the DT cord-010092-uftc8inx 11036 2 hemoglobin hemoglobin NN cord-010092-uftc8inx 11036 3 ( ( -LRB- cord-010092-uftc8inx 11036 4 Hb Hb NNP cord-010092-uftc8inx 11036 5 ) ) -RRB- cord-010092-uftc8inx 11036 6 content content NN cord-010092-uftc8inx 11036 7 of of IN cord-010092-uftc8inx 11036 8 packed packed JJ cord-010092-uftc8inx 11036 9 red red JJ cord-010092-uftc8inx 11036 10 blood blood NN cord-010092-uftc8inx 11036 11 cell cell NN cord-010092-uftc8inx 11036 12 ( ( -LRB- cord-010092-uftc8inx 11036 13 PRBC PRBC NNP cord-010092-uftc8inx 11036 14 ) ) -RRB- cord-010092-uftc8inx 11036 15 units unit NNS cord-010092-uftc8inx 11036 16 is be VBZ cord-010092-uftc8inx 11036 17 heterogenous heterogenous JJ cord-010092-uftc8inx 11036 18 . . . cord-010092-uftc8inx 11037 1 The the DT cord-010092-uftc8inx 11037 2 patient patient NN cord-010092-uftc8inx 11037 3 's 's POS cord-010092-uftc8inx 11037 4 blood blood NN cord-010092-uftc8inx 11037 5 volume volume NN cord-010092-uftc8inx 11037 6 is be VBZ cord-010092-uftc8inx 11037 7 also also RB cord-010092-uftc8inx 11037 8 variable variable JJ cord-010092-uftc8inx 11037 9 which which WDT cord-010092-uftc8inx 11037 10 can can MD cord-010092-uftc8inx 11037 11 be be VB cord-010092-uftc8inx 11037 12 calculated calculate VBN cord-010092-uftc8inx 11037 13 based base VBN cord-010092-uftc8inx 11037 14 on on IN cord-010092-uftc8inx 11037 15 the the DT cord-010092-uftc8inx 11037 16 weight weight NN cord-010092-uftc8inx 11037 17 , , , cord-010092-uftc8inx 11037 18 height height NN cord-010092-uftc8inx 11037 19 and and CC cord-010092-uftc8inx 11037 20 body body NN cord-010092-uftc8inx 11037 21 surface surface NN cord-010092-uftc8inx 11037 22 area area NN cord-010092-uftc8inx 11037 23 ( ( -LRB- cord-010092-uftc8inx 11037 24 BSA BSA NNP cord-010092-uftc8inx 11037 25 ) ) -RRB- cord-010092-uftc8inx 11037 26 of of IN cord-010092-uftc8inx 11037 27 the the DT cord-010092-uftc8inx 11037 28 patient patient NN cord-010092-uftc8inx 11037 29 . . . cord-010092-uftc8inx 11038 1 The the DT cord-010092-uftc8inx 11038 2 efficacy efficacy NN cord-010092-uftc8inx 11038 3 of of IN cord-010092-uftc8inx 11038 4 a a DT cord-010092-uftc8inx 11038 5 transfusion transfusion NN cord-010092-uftc8inx 11038 6 episode episode NN cord-010092-uftc8inx 11038 7 can can MD cord-010092-uftc8inx 11038 8 be be VB cord-010092-uftc8inx 11038 9 assessed assess VBN cord-010092-uftc8inx 11038 10 if if IN cord-010092-uftc8inx 11038 11 the the DT cord-010092-uftc8inx 11038 12 Hb Hb NNP cord-010092-uftc8inx 11038 13 content content NN cord-010092-uftc8inx 11038 14 of of IN cord-010092-uftc8inx 11038 15 PRBC PRBC NNP cord-010092-uftc8inx 11038 16 is be VBZ cord-010092-uftc8inx 11038 17 known know VBN cord-010092-uftc8inx 11038 18 and and CC cord-010092-uftc8inx 11038 19 the the DT cord-010092-uftc8inx 11038 20 patient patient NN cord-010092-uftc8inx 11038 21 's 's POS cord-010092-uftc8inx 11038 22 post post JJ cord-010092-uftc8inx 11038 23 - - JJ cord-010092-uftc8inx 11038 24 transfusion transfusion NN cord-010092-uftc8inx 11038 25 Hb Hb NNP cord-010092-uftc8inx 11038 26 increment increment NN cord-010092-uftc8inx 11038 27 is be VBZ cord-010092-uftc8inx 11038 28 determined determine VBN cord-010092-uftc8inx 11038 29 . . . cord-010092-uftc8inx 11039 1 Aims aim VBZ cord-010092-uftc8inx 11039 2 : : : cord-010092-uftc8inx 11040 1 This this DT cord-010092-uftc8inx 11040 2 prospective prospective JJ cord-010092-uftc8inx 11040 3 study study NN cord-010092-uftc8inx 11040 4 was be VBD cord-010092-uftc8inx 11040 5 performed perform VBN cord-010092-uftc8inx 11040 6 to to TO cord-010092-uftc8inx 11040 7 compare compare VB cord-010092-uftc8inx 11040 8 the the DT cord-010092-uftc8inx 11040 9 efficacy efficacy NN cord-010092-uftc8inx 11040 10 of of IN cord-010092-uftc8inx 11040 11 the the DT cord-010092-uftc8inx 11040 12 transfusion transfusion NN cord-010092-uftc8inx 11040 13 of of IN cord-010092-uftc8inx 11040 14 PRBCs prbc NNS cord-010092-uftc8inx 11040 15 based base VBN cord-010092-uftc8inx 11040 16 on on IN cord-010092-uftc8inx 11040 17 Hb Hb NNP cord-010092-uftc8inx 11040 18 content content NN cord-010092-uftc8inx 11040 19 versus versus IN cord-010092-uftc8inx 11040 20 the the DT cord-010092-uftc8inx 11040 21 standard standard JJ cord-010092-uftc8inx 11040 22 transfusion transfusion NN cord-010092-uftc8inx 11040 23 practice practice NN cord-010092-uftc8inx 11040 24 in in IN cord-010092-uftc8inx 11040 25 thalassemia thalassemia NN cord-010092-uftc8inx 11040 26 major major JJ cord-010092-uftc8inx 11040 27 patients patient NNS cord-010092-uftc8inx 11040 28 . . . cord-010092-uftc8inx 11041 1 We -PRON- PRP cord-010092-uftc8inx 11041 2 also also RB cord-010092-uftc8inx 11041 3 determined determine VBD cord-010092-uftc8inx 11041 4 the the DT cord-010092-uftc8inx 11041 5 correlation correlation NN cord-010092-uftc8inx 11041 6 between between IN cord-010092-uftc8inx 11041 7 Hb Hb NNP cord-010092-uftc8inx 11041 8 increment increment NN cord-010092-uftc8inx 11041 9 and and CC cord-010092-uftc8inx 11041 10 the the DT cord-010092-uftc8inx 11041 11 Hb Hb NNP cord-010092-uftc8inx 11041 12 content content NN cord-010092-uftc8inx 11041 13 of of IN cord-010092-uftc8inx 11041 14 PRBC PRBC NNP cord-010092-uftc8inx 11041 15 units unit NNS cord-010092-uftc8inx 11041 16 transfused transfuse VBN cord-010092-uftc8inx 11041 17 . . . cord-010092-uftc8inx 11042 1 Methods method NNS cord-010092-uftc8inx 11042 2 : : : cord-010092-uftc8inx 11042 3 A a DT cord-010092-uftc8inx 11042 4 total total NN cord-010092-uftc8inx 11042 5 of of IN cord-010092-uftc8inx 11042 6 160 160 CD cord-010092-uftc8inx 11042 7 registered register VBN cord-010092-uftc8inx 11042 8 thalassemia thalassemia NN cord-010092-uftc8inx 11042 9 major major JJ cord-010092-uftc8inx 11042 10 patients patient NNS cord-010092-uftc8inx 11042 11 of of IN cord-010092-uftc8inx 11042 12 our -PRON- PRP$ cord-010092-uftc8inx 11042 13 institute institute NN cord-010092-uftc8inx 11042 14 were be VBD cord-010092-uftc8inx 11042 15 included include VBN cord-010092-uftc8inx 11042 16 in in IN cord-010092-uftc8inx 11042 17 the the DT cord-010092-uftc8inx 11042 18 study study NN cord-010092-uftc8inx 11042 19 after after IN cord-010092-uftc8inx 11042 20 excluding exclude VBG cord-010092-uftc8inx 11042 21 the the DT cord-010092-uftc8inx 11042 22 patients patient NNS cord-010092-uftc8inx 11042 23 who who WP cord-010092-uftc8inx 11042 24 had have VBD cord-010092-uftc8inx 11042 25 allo allo NN cord-010092-uftc8inx 11042 26 - - HYPH cord-010092-uftc8inx 11042 27 or or CC cord-010092-uftc8inx 11042 28 auto auto NN cord-010092-uftc8inx 11042 29 - - HYPH cord-010092-uftc8inx 11042 30 antibodies antibody NNS cord-010092-uftc8inx 11042 31 . . . cord-010092-uftc8inx 11043 1 The the DT cord-010092-uftc8inx 11043 2 study study NN cord-010092-uftc8inx 11043 3 was be VBD cord-010092-uftc8inx 11043 4 approved approve VBN cord-010092-uftc8inx 11043 5 by by IN cord-010092-uftc8inx 11043 6 the the DT cord-010092-uftc8inx 11043 7 Institute Institute NNP cord-010092-uftc8inx 11043 8 Ethics Ethics NNP cord-010092-uftc8inx 11043 9 Committee Committee NNP cord-010092-uftc8inx 11043 10 . . . cord-010092-uftc8inx 11044 1 The the DT cord-010092-uftc8inx 11044 2 enrolled enrol VBN cord-010092-uftc8inx 11044 3 patients patient NNS cord-010092-uftc8inx 11044 4 were be VBD cord-010092-uftc8inx 11044 5 randomly randomly RB cord-010092-uftc8inx 11044 6 divided divide VBN cord-010092-uftc8inx 11044 7 into into IN cord-010092-uftc8inx 11044 8 two two CD cord-010092-uftc8inx 11044 9 groups group NNS cord-010092-uftc8inx 11044 10 : : : cord-010092-uftc8inx 11045 1 Group group NN cord-010092-uftc8inx 11045 2 I -PRON- PRP cord-010092-uftc8inx 11046 1 ( ( -LRB- cord-010092-uftc8inx 11046 2 n n NN cord-010092-uftc8inx 11046 3 = = NN cord-010092-uftc8inx 11047 1 80)they 80)they CD cord-010092-uftc8inx 11047 2 received receive VBD cord-010092-uftc8inx 11047 3 ABO ABO NNP cord-010092-uftc8inx 11047 4 / / SYM cord-010092-uftc8inx 11047 5 RhD rhd NN cord-010092-uftc8inx 11047 6 identical identical JJ cord-010092-uftc8inx 11047 7 PRBCs prbc NNS cord-010092-uftc8inx 11047 8 suspended suspend VBN cord-010092-uftc8inx 11047 9 in in IN cord-010092-uftc8inx 11047 10 additive additive NN cord-010092-uftc8inx 11047 11 solution solution NN cord-010092-uftc8inx 11047 12 ( ( -LRB- cord-010092-uftc8inx 11047 13 saline saline NN cord-010092-uftc8inx 11047 14 , , , cord-010092-uftc8inx 11047 15 adenine adenine NN cord-010092-uftc8inx 11047 16 , , , cord-010092-uftc8inx 11047 17 glucose glucose NN cord-010092-uftc8inx 11047 18 , , , cord-010092-uftc8inx 11047 19 mannitol mannitol NN cord-010092-uftc8inx 11047 20 : : : cord-010092-uftc8inx 11047 21 SAGM SAGM NNP cord-010092-uftc8inx 11047 22 - - HYPH cord-010092-uftc8inx 11047 23 PRBCs prbc NNS cord-010092-uftc8inx 11047 24 ) ) -RRB- cord-010092-uftc8inx 11047 25 after after IN cord-010092-uftc8inx 11047 26 determining determine VBG cord-010092-uftc8inx 11047 27 its -PRON- PRP$ cord-010092-uftc8inx 11047 28 Hb Hb NNP cord-010092-uftc8inx 11047 29 content content NN cord-010092-uftc8inx 11047 30 ( ( -LRB- cord-010092-uftc8inx 11047 31 units unit NNS cord-010092-uftc8inx 11047 32 with with IN cord-010092-uftc8inx 11047 33 Hb Hb NNP cord-010092-uftc8inx 11047 34 content content NN cord-010092-uftc8inx 11047 35 ≥ ≥ CD cord-010092-uftc8inx 11047 36 50 50 CD cord-010092-uftc8inx 11047 37 g g NN cord-010092-uftc8inx 11047 38 ) ) -RRB- cord-010092-uftc8inx 11047 39 ; ; : cord-010092-uftc8inx 11047 40 and and CC cord-010092-uftc8inx 11047 41 Group Group NNP cord-010092-uftc8inx 11047 42 II II NNP cord-010092-uftc8inx 11047 43 ( ( -LRB- cord-010092-uftc8inx 11047 44 n n NN cord-010092-uftc8inx 11047 45 = = SYM cord-010092-uftc8inx 11047 46 80)they 80)they CD cord-010092-uftc8inx 11047 47 received receive VBD cord-010092-uftc8inx 11047 48 randomly randomly RB cord-010092-uftc8inx 11047 49 selected select VBN cord-010092-uftc8inx 11047 50 ABO ABO NNP cord-010092-uftc8inx 11047 51 / / SYM cord-010092-uftc8inx 11047 52 RhD rhd NN cord-010092-uftc8inx 11047 53 identical identical JJ cord-010092-uftc8inx 11047 54 SAGM SAGM NNP cord-010092-uftc8inx 11047 55 - - HYPH cord-010092-uftc8inx 11047 56 PRBCs prbc NNS cord-010092-uftc8inx 11047 57 . . . cord-010092-uftc8inx 11048 1 The the DT cord-010092-uftc8inx 11048 2 Hb Hb NNP cord-010092-uftc8inx 11048 3 estimation estimation NN cord-010092-uftc8inx 11048 4 of of IN cord-010092-uftc8inx 11048 5 the the DT cord-010092-uftc8inx 11048 6 randomly randomly RB cord-010092-uftc8inx 11048 7 selected select VBN cord-010092-uftc8inx 11048 8 units unit NNS cord-010092-uftc8inx 11048 9 in in IN cord-010092-uftc8inx 11048 10 group group NN cord-010092-uftc8inx 11048 11 II II NNP cord-010092-uftc8inx 11048 12 was be VBD cord-010092-uftc8inx 11048 13 blinded blind VBN cord-010092-uftc8inx 11048 14 . . . cord-010092-uftc8inx 11049 1 Following follow VBG cord-010092-uftc8inx 11049 2 tests test NNS cord-010092-uftc8inx 11049 3 were be VBD cord-010092-uftc8inx 11049 4 done do VBN cord-010092-uftc8inx 11049 5 on on IN cord-010092-uftc8inx 11049 6 pre pre JJ cord-010092-uftc8inx 11049 7 - - JJ cord-010092-uftc8inx 11049 8 transfusion transfusion JJ cord-010092-uftc8inx 11049 9 sample sample NN cord-010092-uftc8inx 11049 10 : : : cord-010092-uftc8inx 11050 1 Hb Hb NNP cord-010092-uftc8inx 11050 2 estimation estimation NN cord-010092-uftc8inx 11050 3 using use VBG cord-010092-uftc8inx 11050 4 the the DT cord-010092-uftc8inx 11050 5 hematology hematology NN cord-010092-uftc8inx 11050 6 analyzer analyzer NN cord-010092-uftc8inx 11050 7 ( ( -LRB- cord-010092-uftc8inx 11050 8 Orion Orion NNP cord-010092-uftc8inx 11050 9 60 60 CD cord-010092-uftc8inx 11050 10 , , , cord-010092-uftc8inx 11050 11 Ocean Ocean NNP cord-010092-uftc8inx 11050 12 Medical Medical NNP cord-010092-uftc8inx 11050 13 Technologies Technologies NNPS cord-010092-uftc8inx 11050 14 , , , cord-010092-uftc8inx 11050 15 India India NNP cord-010092-uftc8inx 11050 16 ) ) -RRB- cord-010092-uftc8inx 11050 17 , , , cord-010092-uftc8inx 11050 18 blood blood NN cord-010092-uftc8inx 11050 19 grouping grouping NN cord-010092-uftc8inx 11050 20 using use VBG cord-010092-uftc8inx 11050 21 tube tube NN cord-010092-uftc8inx 11050 22 technique technique NN cord-010092-uftc8inx 11050 23 , , , cord-010092-uftc8inx 11050 24 anti anti JJ cord-010092-uftc8inx 11050 25 - - JJ cord-010092-uftc8inx 11050 26 human human JJ cord-010092-uftc8inx 11050 27 globulin globulin NN cord-010092-uftc8inx 11050 28 ( ( -LRB- cord-010092-uftc8inx 11050 29 AHG AHG NNP cord-010092-uftc8inx 11050 30 ) ) -RRB- cord-010092-uftc8inx 11050 31 crossmatch crossmatch NN cord-010092-uftc8inx 11050 32 and and CC cord-010092-uftc8inx 11050 33 direct direct JJ cord-010092-uftc8inx 11050 34 antiglobulin antiglobulin NN cord-010092-uftc8inx 11050 35 test test NN cord-010092-uftc8inx 11051 1 ( ( -LRB- cord-010092-uftc8inx 11051 2 DAT DAT NNP cord-010092-uftc8inx 11051 3 ) ) -RRB- cord-010092-uftc8inx 11051 4 using use VBG cord-010092-uftc8inx 11051 5 gel gel NN cord-010092-uftc8inx 11051 6 technique technique NN cord-010092-uftc8inx 11051 7 ( ( -LRB- cord-010092-uftc8inx 11051 8 Biorad Biorad NNP cord-010092-uftc8inx 11051 9 , , , cord-010092-uftc8inx 11051 10 Switzerland Switzerland NNP cord-010092-uftc8inx 11051 11 ) ) -RRB- cord-010092-uftc8inx 11051 12 , , , cord-010092-uftc8inx 11051 13 antibody antibody NN cord-010092-uftc8inx 11051 14 screening screening NN cord-010092-uftc8inx 11051 15 ( ( -LRB- cord-010092-uftc8inx 11051 16 ABS abs NN cord-010092-uftc8inx 11051 17 ) ) -RRB- cord-010092-uftc8inx 11051 18 using use VBG cord-010092-uftc8inx 11051 19 a a DT cord-010092-uftc8inx 11051 20 fully fully RB cord-010092-uftc8inx 11051 21 automated automate VBN cord-010092-uftc8inx 11051 22 immunohematology immunohematology NN cord-010092-uftc8inx 11051 23 analyzer analyzer NN cord-010092-uftc8inx 11051 24 ( ( -LRB- cord-010092-uftc8inx 11051 25 Neo Neo NNP cord-010092-uftc8inx 11051 26 , , , cord-010092-uftc8inx 11051 27 Immucor Immucor NNP cord-010092-uftc8inx 11051 28 , , , cord-010092-uftc8inx 11051 29 USA USA NNP cord-010092-uftc8inx 11051 30 ) ) -RRB- cord-010092-uftc8inx 11051 31 . . . cord-010092-uftc8inx 11052 1 On on IN cord-010092-uftc8inx 11052 2 the the DT cord-010092-uftc8inx 11052 3 posttransfusion posttransfusion NN cord-010092-uftc8inx 11052 4 sample sample NN cord-010092-uftc8inx 11052 5 collected collect VBD cord-010092-uftc8inx 11052 6 1 1 CD cord-010092-uftc8inx 11052 7 h h NN cord-010092-uftc8inx 11052 8 after after IN cord-010092-uftc8inx 11052 9 transfusion transfusion NN cord-010092-uftc8inx 11052 10 , , , cord-010092-uftc8inx 11052 11 Hb Hb NNP cord-010092-uftc8inx 11052 12 estimation estimation NN cord-010092-uftc8inx 11052 13 and and CC cord-010092-uftc8inx 11052 14 DAT DAT NNP cord-010092-uftc8inx 11052 15 were be VBD cord-010092-uftc8inx 11052 16 performed perform VBN cord-010092-uftc8inx 11052 17 . . . cord-010092-uftc8inx 11053 1 Results result NNS cord-010092-uftc8inx 11053 2 : : : cord-010092-uftc8inx 11054 1 There there EX cord-010092-uftc8inx 11054 2 was be VBD cord-010092-uftc8inx 11054 3 no no DT cord-010092-uftc8inx 11054 4 significant significant JJ cord-010092-uftc8inx 11054 5 difference difference NN cord-010092-uftc8inx 11054 6 among among IN cord-010092-uftc8inx 11054 7 the the DT cord-010092-uftc8inx 11054 8 patient patient JJ cord-010092-uftc8inx 11054 9 characteristics characteristic NNS cord-010092-uftc8inx 11054 10 of of IN cord-010092-uftc8inx 11054 11 the the DT cord-010092-uftc8inx 11054 12 two two CD cord-010092-uftc8inx 11054 13 groups group NNS cord-010092-uftc8inx 11054 14 . . . cord-010092-uftc8inx 11055 1 The the DT cord-010092-uftc8inx 11055 2 mean mean JJ cord-010092-uftc8inx 11055 3 Hb Hb NNP cord-010092-uftc8inx 11055 4 content content NN cord-010092-uftc8inx 11055 5 of of IN cord-010092-uftc8inx 11055 6 the the DT cord-010092-uftc8inx 11055 7 SAGM SAGM NNP cord-010092-uftc8inx 11055 8 - - HYPH cord-010092-uftc8inx 11055 9 PRBC PRBC NNP cord-010092-uftc8inx 11055 10 units unit NNS cord-010092-uftc8inx 11055 11 was be VBD cord-010092-uftc8inx 11055 12 significantly significantly RB cord-010092-uftc8inx 11055 13 higher high JJR cord-010092-uftc8inx 11055 14 ( ( -LRB- cord-010092-uftc8inx 11055 15 P p NN cord-010092-uftc8inx 11055 16 = = SYM cord-010092-uftc8inx 11055 17 0.000 0.000 CD cord-010092-uftc8inx 11055 18 ) ) -RRB- cord-010092-uftc8inx 11055 19 in in IN cord-010092-uftc8inx 11055 20 group group NN cord-010092-uftc8inx 11056 1 I -PRON- PRP cord-010092-uftc8inx 11057 1 ( ( -LRB- cord-010092-uftc8inx 11057 2 Mean mean JJ cord-010092-uftc8inx 11057 3 AE AE NNP cord-010092-uftc8inx 11057 4 standard standard JJ cord-010092-uftc8inx 11057 5 deviation deviation NN cord-010092-uftc8inx 11057 6 : : : cord-010092-uftc8inx 11057 7 67.86 67.86 CD cord-010092-uftc8inx 11057 8 AE AE NNP cord-010092-uftc8inx 11057 9 8.07 8.07 CD cord-010092-uftc8inx 11057 10 g g NN cord-010092-uftc8inx 11057 11 ; ; : cord-010092-uftc8inx 11057 12 range range NN cord-010092-uftc8inx 11057 13 : : : cord-010092-uftc8inx 11057 14 50.80 50.80 CD cord-010092-uftc8inx 11057 15 - - SYM cord-010092-uftc8inx 11057 16 92.13 92.13 CD cord-010092-uftc8inx 11057 17 g g NN cord-010092-uftc8inx 11057 18 ) ) -RRB- cord-010092-uftc8inx 11057 19 than than IN cord-010092-uftc8inx 11057 20 group group NN cord-010092-uftc8inx 11057 21 II II NNP cord-010092-uftc8inx 11057 22 ( ( -LRB- cord-010092-uftc8inx 11057 23 60.92 60.92 CD cord-010092-uftc8inx 11057 24 AE AE NNP cord-010092-uftc8inx 11057 25 8.29 8.29 CD cord-010092-uftc8inx 11057 26 g g NN cord-010092-uftc8inx 11057 27 ; ; : cord-010092-uftc8inx 11058 1 range range NN cord-010092-uftc8inx 11058 2 : : : cord-010092-uftc8inx 11058 3 40.86 40.86 CD cord-010092-uftc8inx 11058 4 - - SYM cord-010092-uftc8inx 11058 5 86.76 86.76 CD cord-010092-uftc8inx 11058 6 g g NN cord-010092-uftc8inx 11058 7 ) ) -RRB- cord-010092-uftc8inx 11058 8 . . . cord-010092-uftc8inx 11059 1 The the DT cord-010092-uftc8inx 11059 2 mean mean JJ cord-010092-uftc8inx 11059 3 Hb Hb NNP cord-010092-uftc8inx 11059 4 increment increment NN cord-010092-uftc8inx 11059 5 in in IN cord-010092-uftc8inx 11059 6 group group NN cord-010092-uftc8inx 11059 7 I -PRON- PRP cord-010092-uftc8inx 11059 8 patients patient NNS cord-010092-uftc8inx 11059 9 ( ( -LRB- cord-010092-uftc8inx 11059 10 3.26 3.26 CD cord-010092-uftc8inx 11059 11 AE AE NNP cord-010092-uftc8inx 11059 12 0.83 0.83 CD cord-010092-uftc8inx 11059 13 g g NN cord-010092-uftc8inx 11059 14 / / SYM cord-010092-uftc8inx 11059 15 dl dl NN cord-010092-uftc8inx 11059 16 ) ) -RRB- cord-010092-uftc8inx 11059 17 was be VBD cord-010092-uftc8inx 11059 18 significantly significantly RB cord-010092-uftc8inx 11059 19 higher high JJR cord-010092-uftc8inx 11059 20 ( ( -LRB- cord-010092-uftc8inx 11059 21 P p NN cord-010092-uftc8inx 11059 22 = = SYM cord-010092-uftc8inx 11059 23 0.04 0.04 CD cord-010092-uftc8inx 11059 24 ) ) -RRB- cord-010092-uftc8inx 11059 25 than than IN cord-010092-uftc8inx 11059 26 the the DT cord-010092-uftc8inx 11059 27 group group NN cord-010092-uftc8inx 11059 28 II ii CD cord-010092-uftc8inx 11059 29 patients patient NNS cord-010092-uftc8inx 11059 30 ( ( -LRB- cord-010092-uftc8inx 11059 31 3.00 3.00 CD cord-010092-uftc8inx 11059 32 AE AE NNP cord-010092-uftc8inx 11059 33 0.76 0.76 CD cord-010092-uftc8inx 11059 34 g g NN cord-010092-uftc8inx 11059 35 / / SYM cord-010092-uftc8inx 11059 36 dl dl NN cord-010092-uftc8inx 11059 37 ) ) -RRB- cord-010092-uftc8inx 11059 38 . . . cord-010092-uftc8inx 11060 1 In in IN cord-010092-uftc8inx 11060 2 both both CC cord-010092-uftc8inx 11060 3 the the DT cord-010092-uftc8inx 11060 4 groups group NNS cord-010092-uftc8inx 11060 5 I -PRON- PRP cord-010092-uftc8inx 11060 6 and and CC cord-010092-uftc8inx 11060 7 II II NNP cord-010092-uftc8inx 11060 8 , , , cord-010092-uftc8inx 11060 9 there there EX cord-010092-uftc8inx 11060 10 was be VBD cord-010092-uftc8inx 11060 11 a a DT cord-010092-uftc8inx 11060 12 significant significant JJ cord-010092-uftc8inx 11060 13 negative negative JJ cord-010092-uftc8inx 11060 14 correlation correlation NN cord-010092-uftc8inx 11060 15 between between IN cord-010092-uftc8inx 11060 16 Hb Hb NNP cord-010092-uftc8inx 11060 17 increment increment NN cord-010092-uftc8inx 11060 18 and and CC cord-010092-uftc8inx 11060 19 weight weight NN cord-010092-uftc8inx 11060 20 ( ( -LRB- cord-010092-uftc8inx 11060 21 P p NN cord-010092-uftc8inx 11060 22 = = SYM cord-010092-uftc8inx 11060 23 0.000 0.000 CD cord-010092-uftc8inx 11060 24 in in IN cord-010092-uftc8inx 11060 25 groups group NNS cord-010092-uftc8inx 11061 1 I -PRON- PRP cord-010092-uftc8inx 11061 2 and and CC cord-010092-uftc8inx 11061 3 II II NNP cord-010092-uftc8inx 11061 4 ) ) -RRB- cord-010092-uftc8inx 11061 5 , , , cord-010092-uftc8inx 11061 6 age age NN cord-010092-uftc8inx 11061 7 ( ( -LRB- cord-010092-uftc8inx 11061 8 P p NN cord-010092-uftc8inx 11061 9 = = SYM cord-010092-uftc8inx 11061 10 0.001 0.001 CD cord-010092-uftc8inx 11061 11 for for IN cord-010092-uftc8inx 11061 12 group group NN cord-010092-uftc8inx 11061 13 I i NN cord-010092-uftc8inx 11061 14 ; ; : cord-010092-uftc8inx 11061 15 P p NN cord-010092-uftc8inx 11061 16 = = SYM cord-010092-uftc8inx 11061 17 0.032 0.032 CD cord-010092-uftc8inx 11061 18 for for IN cord-010092-uftc8inx 11061 19 group group NN cord-010092-uftc8inx 11061 20 II ii CD cord-010092-uftc8inx 11061 21 ) ) -RRB- cord-010092-uftc8inx 11062 1 , , , cord-010092-uftc8inx 11062 2 body body NN cord-010092-uftc8inx 11062 3 surface surface NN cord-010092-uftc8inx 11062 4 area area NN cord-010092-uftc8inx 11062 5 ( ( -LRB- cord-010092-uftc8inx 11062 6 BSA BSA NNP cord-010092-uftc8inx 11062 7 ) ) -RRB- cord-010092-uftc8inx 11063 1 ( ( -LRB- cord-010092-uftc8inx 11063 2 P p NN cord-010092-uftc8inx 11063 3 = = SYM cord-010092-uftc8inx 11063 4 0.002 0.002 NN cord-010092-uftc8inx 11063 5 for for IN cord-010092-uftc8inx 11063 6 group group NN cord-010092-uftc8inx 11063 7 I i NN cord-010092-uftc8inx 11063 8 ; ; : cord-010092-uftc8inx 11063 9 P p NN cord-010092-uftc8inx 11063 10 = = SYM cord-010092-uftc8inx 11063 11 0.000 0.000 CD cord-010092-uftc8inx 11063 12 for for IN cord-010092-uftc8inx 11063 13 group group NN cord-010092-uftc8inx 11063 14 II II NNP cord-010092-uftc8inx 11063 15 ) ) -RRB- cord-010092-uftc8inx 11063 16 and and CC cord-010092-uftc8inx 11063 17 blood blood NN cord-010092-uftc8inx 11063 18 volume volume NN cord-010092-uftc8inx 11064 1 ( ( -LRB- cord-010092-uftc8inx 11064 2 P p NN cord-010092-uftc8inx 11064 3 = = SYM cord-010092-uftc8inx 11064 4 0.006 0.006 CD cord-010092-uftc8inx 11064 5 for for IN cord-010092-uftc8inx 11064 6 group group NN cord-010092-uftc8inx 11064 7 I i NN cord-010092-uftc8inx 11064 8 ; ; : cord-010092-uftc8inx 11064 9 P p NN cord-010092-uftc8inx 11064 10 = = SYM cord-010092-uftc8inx 11064 11 0.000 0.000 CD cord-010092-uftc8inx 11064 12 in in IN cord-010092-uftc8inx 11064 13 group group NN cord-010092-uftc8inx 11064 14 II II NNP cord-010092-uftc8inx 11064 15 ) ) -RRB- cord-010092-uftc8inx 11064 16 . . . cord-010092-uftc8inx 11065 1 In in IN cord-010092-uftc8inx 11065 2 both both CC cord-010092-uftc8inx 11065 3 the the DT cord-010092-uftc8inx 11065 4 groups group NNS cord-010092-uftc8inx 11065 5 I -PRON- PRP cord-010092-uftc8inx 11065 6 and and CC cord-010092-uftc8inx 11065 7 II II NNP cord-010092-uftc8inx 11065 8 , , , cord-010092-uftc8inx 11065 9 there there EX cord-010092-uftc8inx 11065 10 was be VBD cord-010092-uftc8inx 11065 11 a a DT cord-010092-uftc8inx 11065 12 significant significant JJ cord-010092-uftc8inx 11065 13 positive positive JJ cord-010092-uftc8inx 11065 14 correlation correlation NN cord-010092-uftc8inx 11065 15 between between IN cord-010092-uftc8inx 11065 16 Hb Hb NNP cord-010092-uftc8inx 11065 17 increment increment NN cord-010092-uftc8inx 11065 18 and and CC cord-010092-uftc8inx 11065 19 Hb Hb NNP cord-010092-uftc8inx 11065 20 dose dose NN cord-010092-uftc8inx 11065 21 adjusted adjust VBN cord-010092-uftc8inx 11065 22 for for IN cord-010092-uftc8inx 11065 23 BSA BSA NNP cord-010092-uftc8inx 11065 24 and and CC cord-010092-uftc8inx 11065 25 the the DT cord-010092-uftc8inx 11065 26 Hb Hb NNP cord-010092-uftc8inx 11065 27 dose dose NN cord-010092-uftc8inx 11065 28 adjusted adjust VBN cord-010092-uftc8inx 11065 29 for for IN cord-010092-uftc8inx 11065 30 blood blood NN cord-010092-uftc8inx 11065 31 volume volume NN cord-010092-uftc8inx 11065 32 ( ( -LRB- cord-010092-uftc8inx 11065 33 P p NN cord-010092-uftc8inx 11065 34 = = SYM cord-010092-uftc8inx 11065 35 0.000 0.000 CD cord-010092-uftc8inx 11065 36 in in IN cord-010092-uftc8inx 11065 37 both both DT cord-010092-uftc8inx 11065 38 groups group NNS cord-010092-uftc8inx 11065 39 I -PRON- PRP cord-010092-uftc8inx 11065 40 and and CC cord-010092-uftc8inx 11065 41 II II NNP cord-010092-uftc8inx 11065 42 for for IN cord-010092-uftc8inx 11065 43 both both CC cord-010092-uftc8inx 11065 44 the the DT cord-010092-uftc8inx 11065 45 parameters parameter NNS cord-010092-uftc8inx 11065 46 ) ) -RRB- cord-010092-uftc8inx 11065 47 . . . cord-010092-uftc8inx 11066 1 Summary Summary NNP cord-010092-uftc8inx 11066 2 / / SYM cord-010092-uftc8inx 11066 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 11066 4 : : : cord-010092-uftc8inx 11067 1 The the DT cord-010092-uftc8inx 11067 2 efficacy efficacy NN cord-010092-uftc8inx 11067 3 of of IN cord-010092-uftc8inx 11067 4 transfusion transfusion NN cord-010092-uftc8inx 11067 5 is be VBZ cord-010092-uftc8inx 11067 6 more more JJR cord-010092-uftc8inx 11067 7 when when WRB cord-010092-uftc8inx 11067 8 patients patient NNS cord-010092-uftc8inx 11067 9 are be VBP cord-010092-uftc8inx 11067 10 transfused transfuse VBN cord-010092-uftc8inx 11067 11 with with IN cord-010092-uftc8inx 11067 12 SAGM SAGM NNP cord-010092-uftc8inx 11067 13 - - HYPH cord-010092-uftc8inx 11067 14 PRBCs prbc NNS cord-010092-uftc8inx 11067 15 having have VBG cord-010092-uftc8inx 11067 16 Hb Hb NNP cord-010092-uftc8inx 11067 17 content content NN cord-010092-uftc8inx 11067 18 of of IN cord-010092-uftc8inx 11067 19 50 50 CD cord-010092-uftc8inx 11067 20 g g NN cord-010092-uftc8inx 11067 21 or or CC cord-010092-uftc8inx 11067 22 more more JJR cord-010092-uftc8inx 11067 23 as as IN cord-010092-uftc8inx 11067 24 compared compare VBN cord-010092-uftc8inx 11067 25 to to IN cord-010092-uftc8inx 11067 26 those those DT cord-010092-uftc8inx 11067 27 who who WP cord-010092-uftc8inx 11067 28 are be VBP cord-010092-uftc8inx 11067 29 transfused transfuse VBN cord-010092-uftc8inx 11067 30 with with IN cord-010092-uftc8inx 11067 31 randomly randomly RB cord-010092-uftc8inx 11067 32 selected select VBN cord-010092-uftc8inx 11067 33 units unit NNS cord-010092-uftc8inx 11067 34 . . . cord-010092-uftc8inx 11068 1 For for IN cord-010092-uftc8inx 11068 2 optimal optimal JJ cord-010092-uftc8inx 11068 3 Hb Hb NNP cord-010092-uftc8inx 11068 4 increment increment NN cord-010092-uftc8inx 11068 5 in in IN cord-010092-uftc8inx 11068 6 thalassemia thalassemia NN cord-010092-uftc8inx 11068 7 major major JJ cord-010092-uftc8inx 11068 8 patients patient NNS cord-010092-uftc8inx 11068 9 , , , cord-010092-uftc8inx 11068 10 the the DT cord-010092-uftc8inx 11068 11 transfusion transfusion NN cord-010092-uftc8inx 11068 12 strategy strategy NN cord-010092-uftc8inx 11068 13 should should MD cord-010092-uftc8inx 11068 14 be be VB cord-010092-uftc8inx 11068 15 based base VBN cord-010092-uftc8inx 11068 16 on on IN cord-010092-uftc8inx 11068 17 the the DT cord-010092-uftc8inx 11068 18 Hb Hb NNP cord-010092-uftc8inx 11068 19 content content NN cord-010092-uftc8inx 11068 20 of of IN cord-010092-uftc8inx 11068 21 the the DT cord-010092-uftc8inx 11068 22 SAGM SAGM NNP cord-010092-uftc8inx 11068 23 - - HYPH cord-010092-uftc8inx 11068 24 PRBCs prbc NNS cord-010092-uftc8inx 11068 25 . . . cord-010092-uftc8inx 11069 1 Background background NN cord-010092-uftc8inx 11069 2 : : : cord-010092-uftc8inx 11070 1 In in IN cord-010092-uftc8inx 11070 2 male male JJ cord-010092-uftc8inx 11070 3 transfusion transfusion NN cord-010092-uftc8inx 11070 4 recipients recipient NNS cord-010092-uftc8inx 11070 5 under under IN cord-010092-uftc8inx 11070 6 50 50 CD cord-010092-uftc8inx 11070 7 years year NNS cord-010092-uftc8inx 11070 8 of of IN cord-010092-uftc8inx 11070 9 age age NN cord-010092-uftc8inx 11070 10 , , , cord-010092-uftc8inx 11070 11 receiving receive VBG cord-010092-uftc8inx 11070 12 red red JJ cord-010092-uftc8inx 11070 13 blood blood NN cord-010092-uftc8inx 11070 14 cells cell NNS cord-010092-uftc8inx 11070 15 ( ( -LRB- cord-010092-uftc8inx 11070 16 RBCs rbc NNS cord-010092-uftc8inx 11070 17 ) ) -RRB- cord-010092-uftc8inx 11070 18 from from IN cord-010092-uftc8inx 11070 19 an an DT cord-010092-uftc8inx 11070 20 ever ever RB cord-010092-uftc8inx 11070 21 - - HYPH cord-010092-uftc8inx 11070 22 pregnant pregnant JJ cord-010092-uftc8inx 11070 23 blood blood NN cord-010092-uftc8inx 11070 24 donor donor NN cord-010092-uftc8inx 11070 25 has have VBZ cord-010092-uftc8inx 11070 26 been be VBN cord-010092-uftc8inx 11070 27 associated associate VBN cord-010092-uftc8inx 11070 28 with with IN cord-010092-uftc8inx 11070 29 increased increase VBN cord-010092-uftc8inx 11070 30 mortality mortality NN cord-010092-uftc8inx 11070 31 , , , cord-010092-uftc8inx 11070 32 compared compare VBN cord-010092-uftc8inx 11070 33 to to IN cord-010092-uftc8inx 11070 34 receiving receive VBG cord-010092-uftc8inx 11070 35 a a DT cord-010092-uftc8inx 11070 36 product product NN cord-010092-uftc8inx 11070 37 from from IN cord-010092-uftc8inx 11070 38 a a DT cord-010092-uftc8inx 11070 39 male male JJ cord-010092-uftc8inx 11070 40 donor donor NN cord-010092-uftc8inx 11070 41 . . . cord-010092-uftc8inx 11071 1 Although although IN cord-010092-uftc8inx 11071 2 it -PRON- PRP cord-010092-uftc8inx 11071 3 has have VBZ cord-010092-uftc8inx 11071 4 been be VBN cord-010092-uftc8inx 11071 5 suggested suggest VBN cord-010092-uftc8inx 11071 6 that that IN cord-010092-uftc8inx 11071 7 older old JJR cord-010092-uftc8inx 11071 8 units unit NNS cord-010092-uftc8inx 11071 9 of of IN cord-010092-uftc8inx 11071 10 RBCs rbc NNS cord-010092-uftc8inx 11071 11 could could MD cord-010092-uftc8inx 11071 12 be be VB cord-010092-uftc8inx 11071 13 associated associate VBN cord-010092-uftc8inx 11071 14 with with IN cord-010092-uftc8inx 11071 15 increased increase VBN cord-010092-uftc8inx 11071 16 mortality mortality NN cord-010092-uftc8inx 11071 17 , , , cord-010092-uftc8inx 11071 18 there there EX cord-010092-uftc8inx 11071 19 are be VBP cord-010092-uftc8inx 11071 20 significant significant JJ cord-010092-uftc8inx 11071 21 methodological methodological JJ cord-010092-uftc8inx 11071 22 challenges challenge NNS cord-010092-uftc8inx 11071 23 in in IN cord-010092-uftc8inx 11071 24 these these DT cord-010092-uftc8inx 11071 25 studies study NNS cord-010092-uftc8inx 11071 26 . . . cord-010092-uftc8inx 11072 1 Other other JJ cord-010092-uftc8inx 11072 2 studies study NNS cord-010092-uftc8inx 11072 3 indicated indicate VBD cord-010092-uftc8inx 11072 4 the the DT cord-010092-uftc8inx 11072 5 freshest fresh JJS cord-010092-uftc8inx 11072 6 units unit NNS cord-010092-uftc8inx 11072 7 of of IN cord-010092-uftc8inx 11072 8 RBCs rbc NNS cord-010092-uftc8inx 11072 9 could could MD cord-010092-uftc8inx 11072 10 be be VB cord-010092-uftc8inx 11072 11 associated associate VBN cord-010092-uftc8inx 11072 12 with with IN cord-010092-uftc8inx 11072 13 increased increase VBN cord-010092-uftc8inx 11072 14 mortality mortality NN cord-010092-uftc8inx 11072 15 among among IN cord-010092-uftc8inx 11072 16 transfusion transfusion NN cord-010092-uftc8inx 11072 17 recipients recipient NNS cord-010092-uftc8inx 11072 18 . . . cord-010092-uftc8inx 11073 1 We -PRON- PRP cord-010092-uftc8inx 11073 2 hypothesize hypothesize VBP cord-010092-uftc8inx 11073 3 both both CC cord-010092-uftc8inx 11073 4 the the DT cord-010092-uftc8inx 11073 5 association association NN cord-010092-uftc8inx 11073 6 between between IN cord-010092-uftc8inx 11073 7 ever ever RB cord-010092-uftc8inx 11073 8 - - HYPH cord-010092-uftc8inx 11073 9 pregnant pregnant JJ cord-010092-uftc8inx 11073 10 donors donor NNS cord-010092-uftc8inx 11073 11 , , , cord-010092-uftc8inx 11073 12 and and CC cord-010092-uftc8inx 11073 13 fresh fresh JJ cord-010092-uftc8inx 11073 14 units unit NNS cord-010092-uftc8inx 11073 15 , , , cord-010092-uftc8inx 11073 16 with with IN cord-010092-uftc8inx 11073 17 mortality mortality NN cord-010092-uftc8inx 11073 18 could could MD cord-010092-uftc8inx 11073 19 be be VB cord-010092-uftc8inx 11073 20 caused cause VBN cord-010092-uftc8inx 11073 21 by by IN cord-010092-uftc8inx 11073 22 passenger passenger NN cord-010092-uftc8inx 11073 23 leukocytes leukocyte NNS cord-010092-uftc8inx 11073 24 in in IN cord-010092-uftc8inx 11073 25 the the DT cord-010092-uftc8inx 11073 26 transfused transfuse VBN cord-010092-uftc8inx 11073 27 RBC RBC NNP cord-010092-uftc8inx 11073 28 units unit NNS cord-010092-uftc8inx 11073 29 , , , cord-010092-uftc8inx 11073 30 which which WDT cord-010092-uftc8inx 11073 31 decay decay VBP cord-010092-uftc8inx 11073 32 during during IN cord-010092-uftc8inx 11073 33 storage storage NN cord-010092-uftc8inx 11073 34 . . . cord-010092-uftc8inx 11074 1 Aims aim VBZ cord-010092-uftc8inx 11074 2 : : : cord-010092-uftc8inx 11074 3 To to TO cord-010092-uftc8inx 11074 4 quantify quantify VB cord-010092-uftc8inx 11074 5 modification modification NN cord-010092-uftc8inx 11074 6 of of IN cord-010092-uftc8inx 11074 7 the the DT cord-010092-uftc8inx 11074 8 effect effect NN cord-010092-uftc8inx 11074 9 of of IN cord-010092-uftc8inx 11074 10 ever ever RB cord-010092-uftc8inx 11074 11 - - HYPH cord-010092-uftc8inx 11074 12 pregnant pregnant JJ cord-010092-uftc8inx 11074 13 donors donor NNS cord-010092-uftc8inx 11074 14 on on IN cord-010092-uftc8inx 11074 15 mortality mortality NN cord-010092-uftc8inx 11074 16 in in IN cord-010092-uftc8inx 11074 17 young young JJ cord-010092-uftc8inx 11074 18 male male JJ cord-010092-uftc8inx 11074 19 RBC RBC NNP cord-010092-uftc8inx 11074 20 transfusion transfusion NN cord-010092-uftc8inx 11074 21 recipients recipient NNS cord-010092-uftc8inx 11074 22 , , , cord-010092-uftc8inx 11074 23 by by IN cord-010092-uftc8inx 11074 24 storage storage NN cord-010092-uftc8inx 11074 25 time time NN cord-010092-uftc8inx 11074 26 . . . cord-010092-uftc8inx 11075 1 Methods method NNS cord-010092-uftc8inx 11075 2 : : : cord-010092-uftc8inx 11075 3 Data datum NNS cord-010092-uftc8inx 11075 4 on on IN cord-010092-uftc8inx 11075 5 transfusion transfusion NN cord-010092-uftc8inx 11075 6 recipients recipient NNS cord-010092-uftc8inx 11075 7 receiving receive VBG cord-010092-uftc8inx 11075 8 their -PRON- PRP$ cord-010092-uftc8inx 11075 9 first first JJ cord-010092-uftc8inx 11075 10 - - HYPH cord-010092-uftc8inx 11075 11 ever ever RB cord-010092-uftc8inx 11075 12 RBC RBC NNP cord-010092-uftc8inx 11075 13 transfusion transfusion NN cord-010092-uftc8inx 11075 14 in in IN cord-010092-uftc8inx 11075 15 one one CD cord-010092-uftc8inx 11075 16 of of IN cord-010092-uftc8inx 11075 17 six six CD cord-010092-uftc8inx 11075 18 major major JJ cord-010092-uftc8inx 11075 19 Dutch dutch JJ cord-010092-uftc8inx 11075 20 hospitals hospital NNS cord-010092-uftc8inx 11075 21 between between IN cord-010092-uftc8inx 11075 22 20/03/2004 20/03/2004 CD cord-010092-uftc8inx 11075 23 and and CC cord-010092-uftc8inx 11075 24 01/09/2015 01/09/2015 CD cord-010092-uftc8inx 11075 25 was be VBD cord-010092-uftc8inx 11075 26 collected collect VBN cord-010092-uftc8inx 11075 27 . . . cord-010092-uftc8inx 11076 1 For for IN cord-010092-uftc8inx 11076 2 the the DT cord-010092-uftc8inx 11076 3 current current JJ cord-010092-uftc8inx 11076 4 study study NN cord-010092-uftc8inx 11076 5 , , , cord-010092-uftc8inx 11076 6 male male JJ cord-010092-uftc8inx 11076 7 transfusion transfusion NN cord-010092-uftc8inx 11076 8 recipients recipient NNS cord-010092-uftc8inx 11076 9 under under IN cord-010092-uftc8inx 11076 10 50 50 CD cord-010092-uftc8inx 11076 11 years year NNS cord-010092-uftc8inx 11076 12 receiving receive VBG cord-010092-uftc8inx 11076 13 only only RB cord-010092-uftc8inx 11076 14 transfusions transfusion NNS cord-010092-uftc8inx 11076 15 from from IN cord-010092-uftc8inx 11076 16 one one CD cord-010092-uftc8inx 11076 17 donor donor NN cord-010092-uftc8inx 11076 18 sex sex NN cord-010092-uftc8inx 11076 19 exposure exposure NN cord-010092-uftc8inx 11076 20 category category NN cord-010092-uftc8inx 11076 21 were be VBD cord-010092-uftc8inx 11076 22 selected select VBN cord-010092-uftc8inx 11076 23 and and CC cord-010092-uftc8inx 11076 24 followup followup JJ cord-010092-uftc8inx 11076 25 was be VBD cord-010092-uftc8inx 11076 26 censored censor VBN cord-010092-uftc8inx 11076 27 at at IN cord-010092-uftc8inx 11076 28 three three CD cord-010092-uftc8inx 11076 29 years year NNS cord-010092-uftc8inx 11076 30 after after IN cord-010092-uftc8inx 11076 31 transfusion transfusion NN cord-010092-uftc8inx 11076 32 . . . cord-010092-uftc8inx 11077 1 Differences difference NNS cord-010092-uftc8inx 11077 2 in in IN cord-010092-uftc8inx 11077 3 storage storage NN cord-010092-uftc8inx 11077 4 time time NN cord-010092-uftc8inx 11077 5 between between IN cord-010092-uftc8inx 11077 6 groups group NNS cord-010092-uftc8inx 11077 7 were be VBD cord-010092-uftc8inx 11077 8 estimated estimate VBN cord-010092-uftc8inx 11077 9 by by IN cord-010092-uftc8inx 11077 10 linear linear JJ cord-010092-uftc8inx 11077 11 regression regression NN cord-010092-uftc8inx 11077 12 , , , cord-010092-uftc8inx 11077 13 adjusted adjust VBN cord-010092-uftc8inx 11077 14 for for IN cord-010092-uftc8inx 11077 15 total total JJ cord-010092-uftc8inx 11077 16 number number NN cord-010092-uftc8inx 11077 17 of of IN cord-010092-uftc8inx 11077 18 transfusions transfusion NNS cord-010092-uftc8inx 11077 19 , , , cord-010092-uftc8inx 11077 20 patient patient JJ cord-010092-uftc8inx 11077 21 age age NN cord-010092-uftc8inx 11077 22 , , , cord-010092-uftc8inx 11077 23 blood blood NN cord-010092-uftc8inx 11077 24 group group NN cord-010092-uftc8inx 11077 25 , , , cord-010092-uftc8inx 11077 26 transfusion transfusion NN cord-010092-uftc8inx 11077 27 year year NN cord-010092-uftc8inx 11077 28 and and CC cord-010092-uftc8inx 11077 29 month month NN cord-010092-uftc8inx 11077 30 . . . cord-010092-uftc8inx 11078 1 In in IN cord-010092-uftc8inx 11078 2 a a DT cord-010092-uftc8inx 11078 3 single single JJ cord-010092-uftc8inx 11078 4 - - HYPH cord-010092-uftc8inx 11078 5 unit unit NN cord-010092-uftc8inx 11078 6 , , , cord-010092-uftc8inx 11078 7 single single JJ cord-010092-uftc8inx 11078 8 - - HYPH cord-010092-uftc8inx 11078 9 transfusion transfusion NN cord-010092-uftc8inx 11078 10 cohort cohort NN cord-010092-uftc8inx 11078 11 , , , cord-010092-uftc8inx 11078 12 cumulative cumulative JJ cord-010092-uftc8inx 11078 13 mortality mortality NN cord-010092-uftc8inx 11078 14 was be VBD cord-010092-uftc8inx 11078 15 estimated estimate VBN cord-010092-uftc8inx 11078 16 separately separately RB cord-010092-uftc8inx 11078 17 for for IN cord-010092-uftc8inx 11078 18 patients patient NNS cord-010092-uftc8inx 11078 19 receiving receive VBG cord-010092-uftc8inx 11078 20 transfusions transfusion NNS cord-010092-uftc8inx 11078 21 from from IN cord-010092-uftc8inx 11078 22 ever ever RB cord-010092-uftc8inx 11078 23 - - HYPH cord-010092-uftc8inx 11078 24 pregnant pregnant JJ cord-010092-uftc8inx 11078 25 or or CC cord-010092-uftc8inx 11078 26 male male JJ cord-010092-uftc8inx 11078 27 donors donor NNS cord-010092-uftc8inx 11078 28 and and CC cord-010092-uftc8inx 11078 29 for for IN cord-010092-uftc8inx 11078 30 ' ' `` cord-010092-uftc8inx 11078 31 fresh fresh JJ cord-010092-uftc8inx 11078 32 ' ' '' cord-010092-uftc8inx 11078 33 ( ( -LRB- cord-010092-uftc8inx 11078 34 < < NNP cord-010092-uftc8inx 11078 35 10 10 CD cord-010092-uftc8inx 11078 36 days day NNS cord-010092-uftc8inx 11078 37 storage storage NN cord-010092-uftc8inx 11078 38 ) ) -RRB- cord-010092-uftc8inx 11078 39 or or CC cord-010092-uftc8inx 11078 40 ' ' `` cord-010092-uftc8inx 11078 41 old old JJ cord-010092-uftc8inx 11078 42 ' ' '' cord-010092-uftc8inx 11079 1 ( ( -LRB- cord-010092-uftc8inx 11079 2 > > VBZ cord-010092-uftc8inx 11079 3 24 24 CD cord-010092-uftc8inx 11079 4 up up RB cord-010092-uftc8inx 11079 5 to to TO cord-010092-uftc8inx 11079 6 36 36 CD cord-010092-uftc8inx 11079 7 days day NNS cord-010092-uftc8inx 11079 8 storage storage NN cord-010092-uftc8inx 11079 9 ) ) -RRB- cord-010092-uftc8inx 11079 10 RBCs rbc NNS cord-010092-uftc8inx 11079 11 . . . cord-010092-uftc8inx 11080 1 Results result NNS cord-010092-uftc8inx 11080 2 : : : cord-010092-uftc8inx 11081 1 For for IN cord-010092-uftc8inx 11081 2 recipients recipient NNS cord-010092-uftc8inx 11081 3 of of IN cord-010092-uftc8inx 11081 4 only only JJ cord-010092-uftc8inx 11081 5 blood blood NN cord-010092-uftc8inx 11081 6 from from IN cord-010092-uftc8inx 11081 7 male male JJ cord-010092-uftc8inx 11081 8 donors donor NNS cord-010092-uftc8inx 11081 9 , , , cord-010092-uftc8inx 11081 10 the the DT cord-010092-uftc8inx 11081 11 storage storage NN cord-010092-uftc8inx 11081 12 time time NN cord-010092-uftc8inx 11081 13 of of IN cord-010092-uftc8inx 11081 14 the the DT cord-010092-uftc8inx 11081 15 freshest fresh JJS cord-010092-uftc8inx 11081 16 unit unit NN cord-010092-uftc8inx 11081 17 was be VBD cord-010092-uftc8inx 11081 18 0.47 0.47 CD cord-010092-uftc8inx 11081 19 day day NN cord-010092-uftc8inx 11081 20 shorter short JJR cord-010092-uftc8inx 11081 21 when when WRB cord-010092-uftc8inx 11081 22 comparing compare VBG cord-010092-uftc8inx 11081 23 the the DT cord-010092-uftc8inx 11081 24 221 221 CD cord-010092-uftc8inx 11081 25 patients patient NNS cord-010092-uftc8inx 11081 26 who who WP cord-010092-uftc8inx 11081 27 died die VBD cord-010092-uftc8inx 11081 28 , , , cord-010092-uftc8inx 11081 29 to to IN cord-010092-uftc8inx 11081 30 1,623 1,623 CD cord-010092-uftc8inx 11081 31 patients patient NNS cord-010092-uftc8inx 11081 32 who who WP cord-010092-uftc8inx 11081 33 survived survive VBD cord-010092-uftc8inx 11081 34 ( ( -LRB- cord-010092-uftc8inx 11081 35 CI CI NNP cord-010092-uftc8inx 11081 36 : : : cord-010092-uftc8inx 11082 1 À1.41 À1.41 VBN cord-010092-uftc8inx 11082 2 to to IN cord-010092-uftc8inx 11082 3 0.48 0.48 CD cord-010092-uftc8inx 11082 4 ) ) -RRB- cord-010092-uftc8inx 11082 5 . . . cord-010092-uftc8inx 11083 1 For for IN cord-010092-uftc8inx 11083 2 recipients recipient NNS cord-010092-uftc8inx 11083 3 of of IN cord-010092-uftc8inx 11083 4 only only JJ cord-010092-uftc8inx 11083 5 blood blood NN cord-010092-uftc8inx 11083 6 from from IN cord-010092-uftc8inx 11083 7 ever ever RB cord-010092-uftc8inx 11083 8 - - HYPH cord-010092-uftc8inx 11083 9 pregnant pregnant JJ cord-010092-uftc8inx 11083 10 donors donor NNS cord-010092-uftc8inx 11083 11 , , , cord-010092-uftc8inx 11083 12 the the DT cord-010092-uftc8inx 11083 13 storage storage NN cord-010092-uftc8inx 11083 14 time time NN cord-010092-uftc8inx 11083 15 of of IN cord-010092-uftc8inx 11083 16 the the DT cord-010092-uftc8inx 11083 17 freshest fresh JJS cord-010092-uftc8inx 11083 18 unit unit NN cord-010092-uftc8inx 11083 19 was be VBD cord-010092-uftc8inx 11083 20 0.64 0.64 CD cord-010092-uftc8inx 11083 21 day day NN cord-010092-uftc8inx 11083 22 longer long RBR cord-010092-uftc8inx 11083 23 when when WRB cord-010092-uftc8inx 11083 24 comparing compare VBG cord-010092-uftc8inx 11083 25 the the DT cord-010092-uftc8inx 11083 26 27 27 CD cord-010092-uftc8inx 11083 27 patients patient NNS cord-010092-uftc8inx 11083 28 who who WP cord-010092-uftc8inx 11083 29 died die VBD cord-010092-uftc8inx 11083 30 , , , cord-010092-uftc8inx 11083 31 to to IN cord-010092-uftc8inx 11083 32 101 101 CD cord-010092-uftc8inx 11083 33 patients patient NNS cord-010092-uftc8inx 11083 34 who who WP cord-010092-uftc8inx 11083 35 survived survive VBD cord-010092-uftc8inx 11083 36 ( ( -LRB- cord-010092-uftc8inx 11083 37 CI CI NNP cord-010092-uftc8inx 11083 38 : : : cord-010092-uftc8inx 11083 39 À2.53 À2.53 NNP cord-010092-uftc8inx 11083 40 to to IN cord-010092-uftc8inx 11083 41 3.80 3.80 CD cord-010092-uftc8inx 11083 42 ) ) -RRB- cord-010092-uftc8inx 11083 43 . . . cord-010092-uftc8inx 11084 1 In in IN cord-010092-uftc8inx 11084 2 the the DT cord-010092-uftc8inx 11084 3 single single JJ cord-010092-uftc8inx 11084 4 - - HYPH cord-010092-uftc8inx 11084 5 transfusion transfusion NN cord-010092-uftc8inx 11084 6 cohort cohort NN cord-010092-uftc8inx 11084 7 , , , cord-010092-uftc8inx 11084 8 1,280 1,280 CD cord-010092-uftc8inx 11084 9 patients patient NNS cord-010092-uftc8inx 11084 10 received receive VBD cord-010092-uftc8inx 11084 11 a a DT cord-010092-uftc8inx 11084 12 fresh fresh JJ cord-010092-uftc8inx 11084 13 RBC RBC NNP cord-010092-uftc8inx 11084 14 transfusion transfusion NN cord-010092-uftc8inx 11084 15 from from IN cord-010092-uftc8inx 11084 16 a a DT cord-010092-uftc8inx 11084 17 male male JJ cord-010092-uftc8inx 11084 18 donor donor NN cord-010092-uftc8inx 11084 19 , , , cord-010092-uftc8inx 11084 20 52 52 CD cord-010092-uftc8inx 11084 21 of of IN cord-010092-uftc8inx 11084 22 whom whom WP cord-010092-uftc8inx 11084 23 died die VBD cord-010092-uftc8inx 11084 24 ; ; : cord-010092-uftc8inx 11084 25 138 138 CD cord-010092-uftc8inx 11084 26 patients patient NNS cord-010092-uftc8inx 11084 27 received receive VBD cord-010092-uftc8inx 11084 28 a a DT cord-010092-uftc8inx 11084 29 fresh fresh JJ cord-010092-uftc8inx 11084 30 transfusion transfusion NN cord-010092-uftc8inx 11084 31 from from IN cord-010092-uftc8inx 11084 32 an an DT cord-010092-uftc8inx 11084 33 ever ever RB cord-010092-uftc8inx 11084 34 - - HYPH cord-010092-uftc8inx 11084 35 pregnant pregnant JJ cord-010092-uftc8inx 11084 36 female female JJ cord-010092-uftc8inx 11084 37 donor donor NN cord-010092-uftc8inx 11084 38 , , , cord-010092-uftc8inx 11084 39 9 9 CD cord-010092-uftc8inx 11084 40 of of IN cord-010092-uftc8inx 11084 41 whom whom WP cord-010092-uftc8inx 11084 42 died die VBD cord-010092-uftc8inx 11084 43 . . . cord-010092-uftc8inx 11085 1 193 193 CD cord-010092-uftc8inx 11085 2 patients patient NNS cord-010092-uftc8inx 11085 3 received receive VBD cord-010092-uftc8inx 11085 4 an an DT cord-010092-uftc8inx 11085 5 old old JJ cord-010092-uftc8inx 11085 6 transfusion transfusion NN cord-010092-uftc8inx 11085 7 from from IN cord-010092-uftc8inx 11085 8 a a DT cord-010092-uftc8inx 11085 9 male male JJ cord-010092-uftc8inx 11085 10 donor donor NN cord-010092-uftc8inx 11085 11 , , , cord-010092-uftc8inx 11085 12 7 7 CD cord-010092-uftc8inx 11085 13 of of IN cord-010092-uftc8inx 11085 14 whom whom WP cord-010092-uftc8inx 11085 15 died die VBD cord-010092-uftc8inx 11085 16 ; ; : cord-010092-uftc8inx 11085 17 16 16 CD cord-010092-uftc8inx 11085 18 patients patient NNS cord-010092-uftc8inx 11085 19 received receive VBD cord-010092-uftc8inx 11085 20 an an DT cord-010092-uftc8inx 11085 21 old old JJ cord-010092-uftc8inx 11085 22 transfusion transfusion NN cord-010092-uftc8inx 11085 23 from from IN cord-010092-uftc8inx 11085 24 an an DT cord-010092-uftc8inx 11085 25 ever ever RB cord-010092-uftc8inx 11085 26 - - HYPH cord-010092-uftc8inx 11085 27 pregnant pregnant JJ cord-010092-uftc8inx 11085 28 female female NN cord-010092-uftc8inx 11085 29 , , , cord-010092-uftc8inx 11085 30 2 2 CD cord-010092-uftc8inx 11085 31 of of IN cord-010092-uftc8inx 11085 32 whom whom WP cord-010092-uftc8inx 11085 33 died die VBD cord-010092-uftc8inx 11085 34 . . . cord-010092-uftc8inx 11086 1 The the DT cord-010092-uftc8inx 11086 2 3-years 3-years CD cord-010092-uftc8inx 11086 3 cumulative cumulative JJ cord-010092-uftc8inx 11086 4 incidence incidence NN cord-010092-uftc8inx 11086 5 of of IN cord-010092-uftc8inx 11086 6 death death NN cord-010092-uftc8inx 11086 7 among among IN cord-010092-uftc8inx 11086 8 young young JJ cord-010092-uftc8inx 11086 9 male male JJ cord-010092-uftc8inx 11086 10 recipients recipient NNS cord-010092-uftc8inx 11086 11 was be VBD cord-010092-uftc8inx 11086 12 4.7 4.7 CD cord-010092-uftc8inx 11086 13 % % NN cord-010092-uftc8inx 11086 14 ( ( -LRB- cord-010092-uftc8inx 11086 15 confidence confidence NN cord-010092-uftc8inx 11086 16 interval interval NN cord-010092-uftc8inx 11086 17 ( ( -LRB- cord-010092-uftc8inx 11086 18 CI CI NNP cord-010092-uftc8inx 11086 19 ) ) -RRB- cord-010092-uftc8inx 11086 20 : : : cord-010092-uftc8inx 11086 21 3.6 3.6 CD cord-010092-uftc8inx 11086 22 % % NN cord-010092-uftc8inx 11086 23 to to IN cord-010092-uftc8inx 11086 24 6.2 6.2 CD cord-010092-uftc8inx 11086 25 % % NN cord-010092-uftc8inx 11086 26 ) ) -RRB- cord-010092-uftc8inx 11086 27 after after IN cord-010092-uftc8inx 11086 28 a a DT cord-010092-uftc8inx 11086 29 fresh fresh JJ cord-010092-uftc8inx 11086 30 transfusion transfusion NN cord-010092-uftc8inx 11086 31 from from IN cord-010092-uftc8inx 11086 32 a a DT cord-010092-uftc8inx 11086 33 male male JJ cord-010092-uftc8inx 11086 34 donor donor NN cord-010092-uftc8inx 11086 35 and and CC cord-010092-uftc8inx 11086 36 4.8 4.8 CD cord-010092-uftc8inx 11086 37 % % NN cord-010092-uftc8inx 11087 1 ( ( -LRB- cord-010092-uftc8inx 11087 2 CI CI NNP cord-010092-uftc8inx 11087 3 : : : cord-010092-uftc8inx 11087 4 2.2 2.2 CD cord-010092-uftc8inx 11087 5 % % NN cord-010092-uftc8inx 11087 6 to to IN cord-010092-uftc8inx 11087 7 10.4 10.4 CD cord-010092-uftc8inx 11087 8 % % NN cord-010092-uftc8inx 11087 9 ) ) -RRB- cord-010092-uftc8inx 11087 10 after after IN cord-010092-uftc8inx 11087 11 a a DT cord-010092-uftc8inx 11087 12 fresh fresh JJ cord-010092-uftc8inx 11087 13 transfusion transfusion NN cord-010092-uftc8inx 11087 14 from from IN cord-010092-uftc8inx 11087 15 an an DT cord-010092-uftc8inx 11087 16 ever ever RB cord-010092-uftc8inx 11087 17 - - HYPH cord-010092-uftc8inx 11087 18 pregnant pregnant JJ cord-010092-uftc8inx 11087 19 female female JJ cord-010092-uftc8inx 11087 20 donor donor NN cord-010092-uftc8inx 11087 21 . . . cord-010092-uftc8inx 11088 1 The the DT cord-010092-uftc8inx 11088 2 3-years 3-years CD cord-010092-uftc8inx 11088 3 cumulative cumulative JJ cord-010092-uftc8inx 11088 4 incidence incidence NN cord-010092-uftc8inx 11088 5 of of IN cord-010092-uftc8inx 11088 6 death death NN cord-010092-uftc8inx 11088 7 was be VBD cord-010092-uftc8inx 11088 8 7.2 7.2 CD cord-010092-uftc8inx 11088 9 % % NN cord-010092-uftc8inx 11088 10 ( ( -LRB- cord-010092-uftc8inx 11088 11 CI ci NN cord-010092-uftc8inx 11088 12 : : : cord-010092-uftc8inx 11088 13 3.8 3.8 CD cord-010092-uftc8inx 11088 14 % % NN cord-010092-uftc8inx 11088 15 to to IN cord-010092-uftc8inx 11088 16 13.6 13.6 CD cord-010092-uftc8inx 11088 17 % % NN cord-010092-uftc8inx 11088 18 ) ) -RRB- cord-010092-uftc8inx 11088 19 after after IN cord-010092-uftc8inx 11088 20 an an DT cord-010092-uftc8inx 11088 21 old old JJ cord-010092-uftc8inx 11088 22 transfusion transfusion NN cord-010092-uftc8inx 11088 23 from from IN cord-010092-uftc8inx 11088 24 a a DT cord-010092-uftc8inx 11088 25 male male JJ cord-010092-uftc8inx 11088 26 donor donor NN cord-010092-uftc8inx 11088 27 and and CC cord-010092-uftc8inx 11088 28 15.4 15.4 CD cord-010092-uftc8inx 11088 29 % % NN cord-010092-uftc8inx 11088 30 ( ( -LRB- cord-010092-uftc8inx 11088 31 CI ci NN cord-010092-uftc8inx 11088 32 : : : cord-010092-uftc8inx 11088 33 4.1 4.1 CD cord-010092-uftc8inx 11088 34 % % NN cord-010092-uftc8inx 11088 35 to to IN cord-010092-uftc8inx 11088 36 48.8 48.8 CD cord-010092-uftc8inx 11088 37 % % NN cord-010092-uftc8inx 11088 38 ) ) -RRB- cord-010092-uftc8inx 11088 39 after after IN cord-010092-uftc8inx 11088 40 an an DT cord-010092-uftc8inx 11088 41 old old JJ cord-010092-uftc8inx 11088 42 transfusion transfusion NN cord-010092-uftc8inx 11088 43 from from IN cord-010092-uftc8inx 11088 44 an an DT cord-010092-uftc8inx 11088 45 everpregnant everpregnant JJ cord-010092-uftc8inx 11088 46 female female JJ cord-010092-uftc8inx 11088 47 donor donor NN cord-010092-uftc8inx 11088 48 . . . cord-010092-uftc8inx 11089 1 Summary Summary NNP cord-010092-uftc8inx 11089 2 / / SYM cord-010092-uftc8inx 11089 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 11089 4 : : : cord-010092-uftc8inx 11090 1 Prolonged prolonged JJ cord-010092-uftc8inx 11090 2 storage storage NN cord-010092-uftc8inx 11090 3 of of IN cord-010092-uftc8inx 11090 4 RBCs rbc NNS cord-010092-uftc8inx 11090 5 from from IN cord-010092-uftc8inx 11090 6 ever ever RB cord-010092-uftc8inx 11090 7 - - HYPH cord-010092-uftc8inx 11090 8 pregnant pregnant JJ cord-010092-uftc8inx 11090 9 donors donor NNS cord-010092-uftc8inx 11090 10 was be VBD cord-010092-uftc8inx 11090 11 not not RB cord-010092-uftc8inx 11090 12 associated associate VBN cord-010092-uftc8inx 11090 13 with with IN cord-010092-uftc8inx 11090 14 decreased decrease VBN cord-010092-uftc8inx 11090 15 mortality mortality NN cord-010092-uftc8inx 11090 16 at at IN cord-010092-uftc8inx 11090 17 3 3 CD cord-010092-uftc8inx 11090 18 years year NNS cord-010092-uftc8inx 11090 19 . . . cord-010092-uftc8inx 11091 1 Contrary contrary JJ cord-010092-uftc8inx 11091 2 to to IN cord-010092-uftc8inx 11091 3 our -PRON- PRP$ cord-010092-uftc8inx 11091 4 expectations expectation NNS cord-010092-uftc8inx 11091 5 , , , cord-010092-uftc8inx 11091 6 our -PRON- PRP$ cord-010092-uftc8inx 11091 7 results result NNS cord-010092-uftc8inx 11091 8 indicate indicate VBP cord-010092-uftc8inx 11091 9 older old JJR cord-010092-uftc8inx 11091 10 units unit NNS cord-010092-uftc8inx 11091 11 may may MD cord-010092-uftc8inx 11091 12 potentiate potentiate VB cord-010092-uftc8inx 11091 13 the the DT cord-010092-uftc8inx 11091 14 effect effect NN cord-010092-uftc8inx 11091 15 of of IN cord-010092-uftc8inx 11091 16 ever ever RB cord-010092-uftc8inx 11091 17 - - HYPH cord-010092-uftc8inx 11091 18 pregnant pregnant JJ cord-010092-uftc8inx 11091 19 donors donor NNS cord-010092-uftc8inx 11091 20 . . . cord-010092-uftc8inx 11092 1 However however RB cord-010092-uftc8inx 11092 2 , , , cord-010092-uftc8inx 11092 3 due due IN cord-010092-uftc8inx 11092 4 to to IN cord-010092-uftc8inx 11092 5 limited limited JJ cord-010092-uftc8inx 11092 6 sample sample NN cord-010092-uftc8inx 11092 7 size size NN cord-010092-uftc8inx 11092 8 the the DT cord-010092-uftc8inx 11092 9 observed observed JJ cord-010092-uftc8inx 11092 10 differences difference NNS cord-010092-uftc8inx 11092 11 were be VBD cord-010092-uftc8inx 11092 12 not not RB cord-010092-uftc8inx 11092 13 statistically statistically RB cord-010092-uftc8inx 11092 14 significant significant JJ cord-010092-uftc8inx 11092 15 . . . cord-010092-uftc8inx 11093 1 Background background NN cord-010092-uftc8inx 11093 2 : : : cord-010092-uftc8inx 11094 1 According accord VBG cord-010092-uftc8inx 11094 2 to to IN cord-010092-uftc8inx 11094 3 the the DT cord-010092-uftc8inx 11094 4 literature literature NN cord-010092-uftc8inx 11094 5 review review NN cord-010092-uftc8inx 11094 6 , , , cord-010092-uftc8inx 11094 7 there there EX cord-010092-uftc8inx 11094 8 was be VBD cord-010092-uftc8inx 11094 9 limited limited JJ cord-010092-uftc8inx 11094 10 impact impact NN cord-010092-uftc8inx 11094 11 of of IN cord-010092-uftc8inx 11094 12 premedication premedication NN cord-010092-uftc8inx 11094 13 ( ( -LRB- cord-010092-uftc8inx 11094 14 antipyretics antipyretic NNS cord-010092-uftc8inx 11094 15 , , , cord-010092-uftc8inx 11094 16 antihistamines antihistamine NNS cord-010092-uftc8inx 11094 17 and and CC cord-010092-uftc8inx 11094 18 steroids steroid NNS cord-010092-uftc8inx 11094 19 ) ) -RRB- cord-010092-uftc8inx 11094 20 before before IN cord-010092-uftc8inx 11094 21 transfusion transfusion NN cord-010092-uftc8inx 11094 22 on on IN cord-010092-uftc8inx 11094 23 the the DT cord-010092-uftc8inx 11094 24 prevention prevention NN cord-010092-uftc8inx 11094 25 of of IN cord-010092-uftc8inx 11094 26 adverse adverse JJ cord-010092-uftc8inx 11094 27 transfusion transfusion NN cord-010092-uftc8inx 11094 28 reactions reaction NNS cord-010092-uftc8inx 11094 29 ( ( -LRB- cord-010092-uftc8inx 11094 30 ATRs atr NNS cord-010092-uftc8inx 11094 31 ) ) -RRB- cord-010092-uftc8inx 11094 32 . . . cord-010092-uftc8inx 11095 1 However however RB cord-010092-uftc8inx 11095 2 , , , cord-010092-uftc8inx 11095 3 the the DT cord-010092-uftc8inx 11095 4 necessity necessity NN cord-010092-uftc8inx 11095 5 of of IN cord-010092-uftc8inx 11095 6 premedication premedication NN cord-010092-uftc8inx 11095 7 remains remain VBZ cord-010092-uftc8inx 11095 8 controversial controversial JJ cord-010092-uftc8inx 11095 9 . . . cord-010092-uftc8inx 11096 1 The the DT cord-010092-uftc8inx 11096 2 premedication premedication NN cord-010092-uftc8inx 11096 3 before before IN cord-010092-uftc8inx 11096 4 transfusion transfusion NN cord-010092-uftc8inx 11096 5 is be VBZ cord-010092-uftc8inx 11096 6 still still RB cord-010092-uftc8inx 11096 7 a a DT cord-010092-uftc8inx 11096 8 common common JJ cord-010092-uftc8inx 11096 9 clinical clinical JJ cord-010092-uftc8inx 11096 10 practice practice NN cord-010092-uftc8inx 11096 11 in in IN cord-010092-uftc8inx 11096 12 Pacific Pacific NNP cord-010092-uftc8inx 11096 13 - - HYPH cord-010092-uftc8inx 11096 14 Asian asian JJ cord-010092-uftc8inx 11096 15 countries country NNS cord-010092-uftc8inx 11096 16 , , , cord-010092-uftc8inx 11096 17 along along IN cord-010092-uftc8inx 11096 18 with with IN cord-010092-uftc8inx 11096 19 the the DT cord-010092-uftc8inx 11096 20 premedication premedication NN cord-010092-uftc8inx 11096 21 rate rate NN cord-010092-uftc8inx 11096 22 ranging range VBG cord-010092-uftc8inx 11096 23 from from IN cord-010092-uftc8inx 11096 24 50 50 CD cord-010092-uftc8inx 11096 25 to to TO cord-010092-uftc8inx 11096 26 80 80 CD cord-010092-uftc8inx 11096 27 % % NN cord-010092-uftc8inx 11096 28 . . . cord-010092-uftc8inx 11097 1 In in IN cord-010092-uftc8inx 11097 2 our -PRON- PRP$ cord-010092-uftc8inx 11097 3 previous previous JJ cord-010092-uftc8inx 11097 4 investigation investigation NN cord-010092-uftc8inx 11097 5 , , , cord-010092-uftc8inx 11097 6 we -PRON- PRP cord-010092-uftc8inx 11097 7 found find VBD cord-010092-uftc8inx 11097 8 that that IN cord-010092-uftc8inx 11097 9 premedication premedication NN cord-010092-uftc8inx 11097 10 rate rate NN cord-010092-uftc8inx 11097 11 was be VBD cord-010092-uftc8inx 11097 12 92.5 92.5 CD cord-010092-uftc8inx 11097 13 % % NN cord-010092-uftc8inx 11097 14 in in IN cord-010092-uftc8inx 11097 15 the the DT cord-010092-uftc8inx 11097 16 outpatients outpatient NNS cord-010092-uftc8inx 11097 17 in in IN cord-010092-uftc8inx 11097 18 2017 2017 CD cord-010092-uftc8inx 11097 19 , , , cord-010092-uftc8inx 11097 20 which which WDT cord-010092-uftc8inx 11097 21 was be VBD cord-010092-uftc8inx 11097 22 much much RB cord-010092-uftc8inx 11097 23 higher high JJR cord-010092-uftc8inx 11097 24 than than IN cord-010092-uftc8inx 11097 25 the the DT cord-010092-uftc8inx 11097 26 reported report VBN cord-010092-uftc8inx 11097 27 rate rate NN cord-010092-uftc8inx 11097 28 in in IN cord-010092-uftc8inx 11097 29 Asia Asia NNP cord-010092-uftc8inx 11097 30 . . . cord-010092-uftc8inx 11098 1 Aims aim VBZ cord-010092-uftc8inx 11098 2 : : : cord-010092-uftc8inx 11099 1 To to TO cord-010092-uftc8inx 11099 2 investigate investigate VB cord-010092-uftc8inx 11099 3 the the DT cord-010092-uftc8inx 11099 4 incidence incidence NN cord-010092-uftc8inx 11099 5 of of IN cord-010092-uftc8inx 11099 6 ATRs atr NNS cord-010092-uftc8inx 11099 7 and and CC cord-010092-uftc8inx 11099 8 decrease decrease VB cord-010092-uftc8inx 11099 9 premedication premedication NN cord-010092-uftc8inx 11099 10 rate rate NN cord-010092-uftc8inx 11099 11 without without IN cord-010092-uftc8inx 11099 12 increasing increase VBG cord-010092-uftc8inx 11099 13 the the DT cord-010092-uftc8inx 11099 14 rate rate NN cord-010092-uftc8inx 11099 15 of of IN cord-010092-uftc8inx 11099 16 ATRs atr NNS cord-010092-uftc8inx 11099 17 via via IN cord-010092-uftc8inx 11099 18 education education NN cord-010092-uftc8inx 11099 19 and and CC cord-010092-uftc8inx 11099 20 evidence evidence NN cord-010092-uftc8inx 11099 21 - - HYPH cord-010092-uftc8inx 11099 22 based base VBN cord-010092-uftc8inx 11099 23 clinical clinical JJ cord-010092-uftc8inx 11099 24 practice practice NN cord-010092-uftc8inx 11099 25 . . . cord-010092-uftc8inx 11100 1 Methods method NNS cord-010092-uftc8inx 11100 2 : : : cord-010092-uftc8inx 11101 1 The the DT cord-010092-uftc8inx 11101 2 incidence incidence NN cord-010092-uftc8inx 11101 3 of of IN cord-010092-uftc8inx 11101 4 ATRs atr NNS cord-010092-uftc8inx 11101 5 from from IN cord-010092-uftc8inx 11101 6 April April NNP cord-010092-uftc8inx 11101 7 to to IN cord-010092-uftc8inx 11101 8 December December NNP cord-010092-uftc8inx 11101 9 , , , cord-010092-uftc8inx 11101 10 2017 2017 CD cord-010092-uftc8inx 11101 11 was be VBD cord-010092-uftc8inx 11101 12 retrospectively retrospectively RB cord-010092-uftc8inx 11101 13 surveyed survey VBN cord-010092-uftc8inx 11101 14 . . . cord-010092-uftc8inx 11102 1 Evidence evidence NN cord-010092-uftc8inx 11102 2 - - HYPH cord-010092-uftc8inx 11102 3 based base VBN cord-010092-uftc8inx 11102 4 clinical clinical JJ cord-010092-uftc8inx 11102 5 practice practice NN cord-010092-uftc8inx 11102 6 was be VBD cord-010092-uftc8inx 11102 7 initiated initiate VBN cord-010092-uftc8inx 11102 8 since since IN cord-010092-uftc8inx 11102 9 January January NNP cord-010092-uftc8inx 11102 10 , , , cord-010092-uftc8inx 11102 11 2018 2018 CD cord-010092-uftc8inx 11102 12 . . . cord-010092-uftc8inx 11103 1 Clinical clinical JJ cord-010092-uftc8inx 11103 2 data datum NNS cord-010092-uftc8inx 11103 3 of of IN cord-010092-uftc8inx 11103 4 the the DT cord-010092-uftc8inx 11103 5 outpatients outpatient NNS cord-010092-uftc8inx 11103 6 receiving receive VBG cord-010092-uftc8inx 11103 7 transfusion transfusion NN cord-010092-uftc8inx 11103 8 therapy therapy NN cord-010092-uftc8inx 11103 9 were be VBD cord-010092-uftc8inx 11103 10 requested request VBN cord-010092-uftc8inx 11103 11 and and CC cord-010092-uftc8inx 11103 12 analyzed analyze VBN cord-010092-uftc8inx 11103 13 from from IN cord-010092-uftc8inx 11103 14 January January NNP cord-010092-uftc8inx 11103 15 to to IN cord-010092-uftc8inx 11103 16 September September NNP cord-010092-uftc8inx 11103 17 , , , cord-010092-uftc8inx 11103 18 2018 2018 CD cord-010092-uftc8inx 11103 19 . . . cord-010092-uftc8inx 11104 1 The the DT cord-010092-uftc8inx 11104 2 incidences incidence NNS cord-010092-uftc8inx 11104 3 of of IN cord-010092-uftc8inx 11104 4 ATRs atr NNS cord-010092-uftc8inx 11104 5 and and CC cord-010092-uftc8inx 11104 6 premedication premedication NN cord-010092-uftc8inx 11104 7 rates rate NNS cord-010092-uftc8inx 11104 8 in in IN cord-010092-uftc8inx 11104 9 2017 2017 CD cord-010092-uftc8inx 11104 10 and and CC cord-010092-uftc8inx 11104 11 2018 2018 CD cord-010092-uftc8inx 11104 12 were be VBD cord-010092-uftc8inx 11104 13 compared compare VBN cord-010092-uftc8inx 11104 14 using use VBG cord-010092-uftc8inx 11104 15 chi chi JJ cord-010092-uftc8inx 11104 16 - - HYPH cord-010092-uftc8inx 11104 17 square square JJ cord-010092-uftc8inx 11104 18 test test NN cord-010092-uftc8inx 11104 19 . . . cord-010092-uftc8inx 11105 1 A a DT cord-010092-uftc8inx 11105 2 P p NN cord-010092-uftc8inx 11105 3 value value NN cord-010092-uftc8inx 11105 4 less less JJR cord-010092-uftc8inx 11105 5 than than IN cord-010092-uftc8inx 11105 6 0.05 0.05 CD cord-010092-uftc8inx 11105 7 was be VBD cord-010092-uftc8inx 11105 8 statistically statistically RB cord-010092-uftc8inx 11105 9 significant significant JJ cord-010092-uftc8inx 11105 10 . . . cord-010092-uftc8inx 11106 1 Besides besides RB cord-010092-uftc8inx 11106 2 , , , cord-010092-uftc8inx 11106 3 feedback feedback NN cord-010092-uftc8inx 11106 4 of of IN cord-010092-uftc8inx 11106 5 the the DT cord-010092-uftc8inx 11106 6 incidence incidence NN cord-010092-uftc8inx 11106 7 of of IN cord-010092-uftc8inx 11106 8 ATRs atr NNS cord-010092-uftc8inx 11106 9 and and CC cord-010092-uftc8inx 11106 10 premedication premedication NN cord-010092-uftc8inx 11106 11 rate rate NN cord-010092-uftc8inx 11106 12 was be VBD cord-010092-uftc8inx 11106 13 given give VBN cord-010092-uftc8inx 11106 14 quarterly quarterly RB cord-010092-uftc8inx 11106 15 to to IN cord-010092-uftc8inx 11106 16 the the DT cord-010092-uftc8inx 11106 17 clinicians clinician NNS cord-010092-uftc8inx 11106 18 during during IN cord-010092-uftc8inx 11106 19 the the DT cord-010092-uftc8inx 11106 20 investigation investigation NN cord-010092-uftc8inx 11106 21 . . . cord-010092-uftc8inx 11107 1 Results result NNS cord-010092-uftc8inx 11107 2 : : : cord-010092-uftc8inx 11108 1 From from IN cord-010092-uftc8inx 11108 2 April April NNP cord-010092-uftc8inx 11108 3 , , , cord-010092-uftc8inx 11108 4 2017 2017 CD cord-010092-uftc8inx 11108 5 to to IN cord-010092-uftc8inx 11108 6 September September NNP cord-010092-uftc8inx 11108 7 , , , cord-010092-uftc8inx 11108 8 2018 2018 CD cord-010092-uftc8inx 11108 9 , , , cord-010092-uftc8inx 11108 10 a a DT cord-010092-uftc8inx 11108 11 total total NN cord-010092-uftc8inx 11108 12 of of IN cord-010092-uftc8inx 11108 13 5,018 5,018 CD cord-010092-uftc8inx 11108 14 blood blood NN cord-010092-uftc8inx 11108 15 units unit NNS cord-010092-uftc8inx 11108 16 were be VBD cord-010092-uftc8inx 11108 17 transfused transfuse VBN cord-010092-uftc8inx 11108 18 in in IN cord-010092-uftc8inx 11108 19 the the DT cord-010092-uftc8inx 11108 20 outpatients outpatient NNS cord-010092-uftc8inx 11108 21 with with IN cord-010092-uftc8inx 11108 22 2,453 2,453 CD cord-010092-uftc8inx 11108 23 transfusion transfusion NN cord-010092-uftc8inx 11108 24 events event NNS cord-010092-uftc8inx 11108 25 . . . cord-010092-uftc8inx 11109 1 Of of IN cord-010092-uftc8inx 11109 2 these these DT cord-010092-uftc8inx 11109 3 , , , cord-010092-uftc8inx 11109 4 25 25 CD cord-010092-uftc8inx 11109 5 cases case NNS cord-010092-uftc8inx 11109 6 of of IN cord-010092-uftc8inx 11109 7 ATRs atr NNS cord-010092-uftc8inx 11109 8 , , , cord-010092-uftc8inx 11109 9 including include VBG cord-010092-uftc8inx 11109 10 febrile febrile JJ cord-010092-uftc8inx 11109 11 nonhemolytic nonhemolytic JJ cord-010092-uftc8inx 11109 12 transfusion transfusion NN cord-010092-uftc8inx 11109 13 reactions reaction NNS cord-010092-uftc8inx 11109 14 ( ( -LRB- cord-010092-uftc8inx 11109 15 FNHTR FNHTR NNP cord-010092-uftc8inx 11109 16 ) ) -RRB- cord-010092-uftc8inx 11109 17 and and CC cord-010092-uftc8inx 11109 18 minor minor JJ cord-010092-uftc8inx 11109 19 allergic allergic JJ cord-010092-uftc8inx 11109 20 reactions reaction NNS cord-010092-uftc8inx 11109 21 were be VBD cord-010092-uftc8inx 11109 22 reported report VBN cord-010092-uftc8inx 11109 23 . . . cord-010092-uftc8inx 11110 1 The the DT cord-010092-uftc8inx 11110 2 overall overall JJ cord-010092-uftc8inx 11110 3 premedication premedication NN cord-010092-uftc8inx 11110 4 rate rate NN cord-010092-uftc8inx 11110 5 in in IN cord-010092-uftc8inx 11110 6 the the DT cord-010092-uftc8inx 11110 7 outpatients outpatient NNS cord-010092-uftc8inx 11110 8 was be VBD cord-010092-uftc8inx 11110 9 92.5 92.5 CD cord-010092-uftc8inx 11110 10 % % NN cord-010092-uftc8inx 11110 11 in in IN cord-010092-uftc8inx 11110 12 2017 2017 CD cord-010092-uftc8inx 11110 13 , , , cord-010092-uftc8inx 11110 14 and and CC cord-010092-uftc8inx 11110 15 was be VBD cord-010092-uftc8inx 11110 16 significantly significantly RB cord-010092-uftc8inx 11110 17 decreased decrease VBN cord-010092-uftc8inx 11110 18 to to IN cord-010092-uftc8inx 11110 19 77.9 77.9 CD cord-010092-uftc8inx 11110 20 % % NN cord-010092-uftc8inx 11110 21 in in IN cord-010092-uftc8inx 11110 22 2018 2018 CD cord-010092-uftc8inx 11111 1 ( ( -LRB- cord-010092-uftc8inx 11111 2 P p NN cord-010092-uftc8inx 11111 3 < < XX cord-010092-uftc8inx 11111 4 0.001 0.001 CD cord-010092-uftc8inx 11111 5 ) ) -RRB- cord-010092-uftc8inx 11111 6 . . . cord-010092-uftc8inx 11112 1 It -PRON- PRP cord-010092-uftc8inx 11112 2 was be VBD cord-010092-uftc8inx 11112 3 reported report VBN cord-010092-uftc8inx 11112 4 that that IN cord-010092-uftc8inx 11112 5 the the DT cord-010092-uftc8inx 11112 6 incidences incidence NNS cord-010092-uftc8inx 11112 7 of of IN cord-010092-uftc8inx 11112 8 ATRs atr NNS cord-010092-uftc8inx 11112 9 in in IN cord-010092-uftc8inx 11112 10 2017 2017 CD cord-010092-uftc8inx 11112 11 and and CC cord-010092-uftc8inx 11112 12 2018 2018 CD cord-010092-uftc8inx 11112 13 were be VBD cord-010092-uftc8inx 11112 14 0.48 0.48 CD cord-010092-uftc8inx 11112 15 % % NN cord-010092-uftc8inx 11112 16 and and CC cord-010092-uftc8inx 11112 17 0.52 0.52 CD cord-010092-uftc8inx 11112 18 % % NN cord-010092-uftc8inx 11112 19 per per IN cord-010092-uftc8inx 11112 20 unit unit NN cord-010092-uftc8inx 11112 21 , , , cord-010092-uftc8inx 11112 22 respectively respectively RB cord-010092-uftc8inx 11112 23 . . . cord-010092-uftc8inx 11113 1 There there EX cord-010092-uftc8inx 11113 2 was be VBD cord-010092-uftc8inx 11113 3 no no DT cord-010092-uftc8inx 11113 4 remarkable remarkable JJ cord-010092-uftc8inx 11113 5 difference difference NN cord-010092-uftc8inx 11113 6 between between IN cord-010092-uftc8inx 11113 7 the the DT cord-010092-uftc8inx 11113 8 incidence incidence NN cord-010092-uftc8inx 11113 9 of of IN cord-010092-uftc8inx 11113 10 ATRs atr NNS cord-010092-uftc8inx 11113 11 in in IN cord-010092-uftc8inx 11113 12 2017 2017 CD cord-010092-uftc8inx 11113 13 and and CC cord-010092-uftc8inx 11113 14 2018 2018 CD cord-010092-uftc8inx 11114 1 ( ( -LRB- cord-010092-uftc8inx 11114 2 P p NN cord-010092-uftc8inx 11114 3 = = SYM cord-010092-uftc8inx 11114 4 0.642 0.642 CD cord-010092-uftc8inx 11114 5 ) ) -RRB- cord-010092-uftc8inx 11114 6 . . . cord-010092-uftc8inx 11115 1 Summary Summary NNP cord-010092-uftc8inx 11115 2 / / SYM cord-010092-uftc8inx 11115 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 11115 4 : : : cord-010092-uftc8inx 11116 1 Via via IN cord-010092-uftc8inx 11116 2 education education NN cord-010092-uftc8inx 11116 3 and and CC cord-010092-uftc8inx 11116 4 evidence evidence NN cord-010092-uftc8inx 11116 5 - - HYPH cord-010092-uftc8inx 11116 6 based base VBN cord-010092-uftc8inx 11116 7 clinical clinical JJ cord-010092-uftc8inx 11116 8 practice practice NN cord-010092-uftc8inx 11116 9 , , , cord-010092-uftc8inx 11116 10 we -PRON- PRP cord-010092-uftc8inx 11116 11 successfully successfully RB cord-010092-uftc8inx 11116 12 reduced reduce VBD cord-010092-uftc8inx 11116 13 premedication premedication NN cord-010092-uftc8inx 11116 14 rate rate NN cord-010092-uftc8inx 11116 15 without without IN cord-010092-uftc8inx 11116 16 increasing increase VBG cord-010092-uftc8inx 11116 17 the the DT cord-010092-uftc8inx 11116 18 rate rate NN cord-010092-uftc8inx 11116 19 of of IN cord-010092-uftc8inx 11116 20 ATRs atr NNS cord-010092-uftc8inx 11116 21 in in IN cord-010092-uftc8inx 11116 22 the the DT cord-010092-uftc8inx 11116 23 outpatients outpatient NNS cord-010092-uftc8inx 11116 24 . . . cord-010092-uftc8inx 11117 1 Furthermore furthermore RB cord-010092-uftc8inx 11117 2 , , , cord-010092-uftc8inx 11117 3 introduction introduction NN cord-010092-uftc8inx 11117 4 of of IN cord-010092-uftc8inx 11117 5 computerized computerized JJ cord-010092-uftc8inx 11117 6 provider provider NN cord-010092-uftc8inx 11117 7 order order NN cord-010092-uftc8inx 11117 8 entry entry NN cord-010092-uftc8inx 11117 9 ( ( -LRB- cord-010092-uftc8inx 11117 10 CPOE CPOE NNP cord-010092-uftc8inx 11117 11 ) ) -RRB- cord-010092-uftc8inx 11117 12 and and CC cord-010092-uftc8inx 11117 13 clinical clinical JJ cord-010092-uftc8inx 11117 14 decision decision NN cord-010092-uftc8inx 11117 15 support support NN cord-010092-uftc8inx 11117 16 system system NN cord-010092-uftc8inx 11117 17 ( ( -LRB- cord-010092-uftc8inx 11117 18 CDSS CDSS NNP cord-010092-uftc8inx 11117 19 ) ) -RRB- cord-010092-uftc8inx 11117 20 could could MD cord-010092-uftc8inx 11117 21 be be VB cord-010092-uftc8inx 11117 22 considered consider VBN cord-010092-uftc8inx 11117 23 and and CC cord-010092-uftc8inx 11117 24 be be VB cord-010092-uftc8inx 11117 25 expected expect VBN cord-010092-uftc8inx 11117 26 to to TO cord-010092-uftc8inx 11117 27 prevent prevent VB cord-010092-uftc8inx 11117 28 unnecessary unnecessary JJ cord-010092-uftc8inx 11117 29 premedication premedication NN cord-010092-uftc8inx 11117 30 before before IN cord-010092-uftc8inx 11117 31 transfusion transfusion NN cord-010092-uftc8inx 11117 32 , , , cord-010092-uftc8inx 11117 33 increasing increase VBG cord-010092-uftc8inx 11117 34 the the DT cord-010092-uftc8inx 11117 35 compliance compliance NN cord-010092-uftc8inx 11117 36 with with IN cord-010092-uftc8inx 11117 37 optimized optimize VBN cord-010092-uftc8inx 11117 38 transfusion transfusion NN cord-010092-uftc8inx 11117 39 strategies strategy NNS cord-010092-uftc8inx 11117 40 in in IN cord-010092-uftc8inx 11117 41 the the DT cord-010092-uftc8inx 11117 42 future future NN cord-010092-uftc8inx 11117 43 . . . cord-010092-uftc8inx 11118 1 Methods method NNS cord-010092-uftc8inx 11118 2 : : : cord-010092-uftc8inx 11119 1 A a DT cord-010092-uftc8inx 11119 2 retrospective retrospective JJ cord-010092-uftc8inx 11119 3 analysis analysis NN cord-010092-uftc8inx 11119 4 was be VBD cord-010092-uftc8inx 11119 5 done do VBN cord-010092-uftc8inx 11119 6 over over IN cord-010092-uftc8inx 11119 7 a a DT cord-010092-uftc8inx 11119 8 period period NN cord-010092-uftc8inx 11119 9 of of IN cord-010092-uftc8inx 11119 10 one one CD cord-010092-uftc8inx 11119 11 year year NN cord-010092-uftc8inx 11119 12 to to TO cord-010092-uftc8inx 11119 13 evaluate evaluate VB cord-010092-uftc8inx 11119 14 clinical clinical JJ cord-010092-uftc8inx 11119 15 efficacy efficacy NN cord-010092-uftc8inx 11119 16 of of IN cord-010092-uftc8inx 11119 17 19 19 CD cord-010092-uftc8inx 11119 18 granulocyte granulocyte NN cord-010092-uftc8inx 11119 19 transfusions transfusion NNS cord-010092-uftc8inx 11119 20 in in IN cord-010092-uftc8inx 11119 21 15 15 CD cord-010092-uftc8inx 11119 22 hemato hemato NNP cord-010092-uftc8inx 11119 23 - - HYPH cord-010092-uftc8inx 11119 24 oncology oncology NN cord-010092-uftc8inx 11119 25 patients patient NNS cord-010092-uftc8inx 11119 26 with with IN cord-010092-uftc8inx 11119 27 febrile febrile JJ cord-010092-uftc8inx 11119 28 neutropenia neutropenia NN cord-010092-uftc8inx 11119 29 . . . cord-010092-uftc8inx 11120 1 Mobilization mobilization NN cord-010092-uftc8inx 11120 2 of of IN cord-010092-uftc8inx 11120 3 granulocyte granulocyte NN cord-010092-uftc8inx 11120 4 donors donor NNS cord-010092-uftc8inx 11120 5 was be VBD cord-010092-uftc8inx 11120 6 done do VBN cord-010092-uftc8inx 11120 7 as as IN cord-010092-uftc8inx 11120 8 per per IN cord-010092-uftc8inx 11120 9 standard standard JJ cord-010092-uftc8inx 11120 10 protocol protocol NN cord-010092-uftc8inx 11120 11 , , , cord-010092-uftc8inx 11120 12 which which WDT cord-010092-uftc8inx 11120 13 included include VBD cord-010092-uftc8inx 11120 14 subcutaneous subcutaneous JJ cord-010092-uftc8inx 11120 15 injection injection NN cord-010092-uftc8inx 11120 16 of of IN cord-010092-uftc8inx 11120 17 granulocyte granulocyte NN cord-010092-uftc8inx 11120 18 colony colony NN cord-010092-uftc8inx 11120 19 stimulating stimulate VBG cord-010092-uftc8inx 11120 20 factor factor NN cord-010092-uftc8inx 11120 21 ( ( -LRB- cord-010092-uftc8inx 11120 22 G G NNP cord-010092-uftc8inx 11120 23 - - HYPH cord-010092-uftc8inx 11120 24 CSF CSF NNP cord-010092-uftc8inx 11120 25 ) ) -RRB- cord-010092-uftc8inx 11120 26 5 5 CD cord-010092-uftc8inx 11120 27 - - SYM cord-010092-uftc8inx 11120 28 10 10 CD cord-010092-uftc8inx 11120 29 lg lg NNP cord-010092-uftc8inx 11120 30 / / SYM cord-010092-uftc8inx 11120 31 kg kg NNP cord-010092-uftc8inx 11120 32 and and CC cord-010092-uftc8inx 11120 33 tablet tablet NN cord-010092-uftc8inx 11120 34 Dexamethasone Dexamethasone NNP cord-010092-uftc8inx 11120 35 8 8 CD cord-010092-uftc8inx 11120 36 mg mg NNP cord-010092-uftc8inx 11120 37 , , , cord-010092-uftc8inx 11120 38 10 10 CD cord-010092-uftc8inx 11120 39 - - SYM cord-010092-uftc8inx 11120 40 12 12 CD cord-010092-uftc8inx 11120 41 h h NN cord-010092-uftc8inx 11120 42 prior prior RB cord-010092-uftc8inx 11120 43 to to IN cord-010092-uftc8inx 11120 44 granulocyte granulocyte NN cord-010092-uftc8inx 11120 45 harvest harvest NN cord-010092-uftc8inx 11120 46 by by IN cord-010092-uftc8inx 11120 47 apheresis apheresis NN cord-010092-uftc8inx 11120 48 . . . cord-010092-uftc8inx 11121 1 All all DT cord-010092-uftc8inx 11121 2 granulocyte granulocyte NN cord-010092-uftc8inx 11121 3 products product NNS cord-010092-uftc8inx 11121 4 were be VBD cord-010092-uftc8inx 11121 5 gamma gamma NN cord-010092-uftc8inx 11121 6 irradiated irradiate VBN cord-010092-uftc8inx 11121 7 before before IN cord-010092-uftc8inx 11121 8 transfusion transfusion NN cord-010092-uftc8inx 11121 9 . . . cord-010092-uftc8inx 11122 1 Patient patient NN cord-010092-uftc8inx 11122 2 parameters parameter NNS cord-010092-uftc8inx 11122 3 like like IN cord-010092-uftc8inx 11122 4 white white JJ cord-010092-uftc8inx 11122 5 blood blood NN cord-010092-uftc8inx 11122 6 count count NN cord-010092-uftc8inx 11122 7 ( ( -LRB- cord-010092-uftc8inx 11122 8 WBC WBC NNP cord-010092-uftc8inx 11122 9 ) ) -RRB- cord-010092-uftc8inx 11122 10 , , , cord-010092-uftc8inx 11122 11 absolute absolute JJ cord-010092-uftc8inx 11122 12 neutrophil neutrophil NN cord-010092-uftc8inx 11122 13 count count NN cord-010092-uftc8inx 11122 14 ( ( -LRB- cord-010092-uftc8inx 11122 15 ANC ANC NNP cord-010092-uftc8inx 11122 16 ) ) -RRB- cord-010092-uftc8inx 11122 17 , , , cord-010092-uftc8inx 11122 18 hemoglobin hemoglobin NN cord-010092-uftc8inx 11122 19 and and CC cord-010092-uftc8inx 11122 20 platelet platelet NN cord-010092-uftc8inx 11122 21 count count NN cord-010092-uftc8inx 11122 22 were be VBD cord-010092-uftc8inx 11122 23 recorded record VBN cord-010092-uftc8inx 11122 24 pre pre JJ cord-010092-uftc8inx 11122 25 - - JJ cord-010092-uftc8inx 11122 26 and and CC cord-010092-uftc8inx 11122 27 post post JJ cord-010092-uftc8inx 11122 28 - - JJ cord-010092-uftc8inx 11122 29 granulocyte granulocyte JJ cord-010092-uftc8inx 11122 30 transfusion transfusion NN cord-010092-uftc8inx 11122 31 . . . cord-010092-uftc8inx 11123 1 Infection infection NN cord-010092-uftc8inx 11123 2 related relate VBN cord-010092-uftc8inx 11123 3 mortality mortality NN cord-010092-uftc8inx 11123 4 ( ( -LRB- cord-010092-uftc8inx 11123 5 IRM IRM NNP cord-010092-uftc8inx 11123 6 ) ) -RRB- cord-010092-uftc8inx 11123 7 within within IN cord-010092-uftc8inx 11123 8 30 30 CD cord-010092-uftc8inx 11123 9 days day NNS cord-010092-uftc8inx 11123 10 of of IN cord-010092-uftc8inx 11123 11 granulocyte granulocyte NN cord-010092-uftc8inx 11123 12 transfusion transfusion NN cord-010092-uftc8inx 11123 13 was be VBD cord-010092-uftc8inx 11123 14 also also RB cord-010092-uftc8inx 11123 15 recorded record VBN cord-010092-uftc8inx 11123 16 . . . cord-010092-uftc8inx 11124 1 Results result NNS cord-010092-uftc8inx 11124 2 : : : cord-010092-uftc8inx 11125 1 Minimum minimum JJ cord-010092-uftc8inx 11125 2 adequate adequate JJ cord-010092-uftc8inx 11125 3 granulocyte granulocyte NN cord-010092-uftc8inx 11125 4 yield yield NN cord-010092-uftc8inx 11125 5 of of IN cord-010092-uftc8inx 11125 6 1 1 CD cord-010092-uftc8inx 11125 7 9 9 CD cord-010092-uftc8inx 11125 8 10 10 CD cord-010092-uftc8inx 11125 9 10 10 CD cord-010092-uftc8inx 11125 10 per per IN cord-010092-uftc8inx 11125 11 unit unit NN cord-010092-uftc8inx 11125 12 was be VBD cord-010092-uftc8inx 11125 13 fulfilled fulfil VBN cord-010092-uftc8inx 11125 14 in in IN cord-010092-uftc8inx 11125 15 90 90 CD cord-010092-uftc8inx 11125 16 % % NN cord-010092-uftc8inx 11125 17 of of IN cord-010092-uftc8inx 11125 18 granulocyte granulocyte NN cord-010092-uftc8inx 11125 19 harvests harvest NNS cord-010092-uftc8inx 11125 20 . . . cord-010092-uftc8inx 11126 1 Clinical clinical JJ cord-010092-uftc8inx 11126 2 indications indication NNS cord-010092-uftc8inx 11126 3 for for IN cord-010092-uftc8inx 11126 4 granulocyte granulocyte NN cord-010092-uftc8inx 11126 5 transfusions transfusion NNS cord-010092-uftc8inx 11126 6 were be VBD cord-010092-uftc8inx 11126 7 fever fever NN cord-010092-uftc8inx 11126 8 , , , cord-010092-uftc8inx 11126 9 an an DT cord-010092-uftc8inx 11126 10 absolute absolute JJ cord-010092-uftc8inx 11126 11 neutrophil neutrophil NN cord-010092-uftc8inx 11126 12 count count NN cord-010092-uftc8inx 11126 13 ( ( -LRB- cord-010092-uftc8inx 11126 14 ANC ANC NNP cord-010092-uftc8inx 11126 15 ) ) -RRB- cord-010092-uftc8inx 11126 16 < < XX cord-010092-uftc8inx 11126 17 500 500 CD cord-010092-uftc8inx 11127 1 /lL /lL NFP cord-010092-uftc8inx 11127 2 , , , cord-010092-uftc8inx 11127 3 evidence evidence NN cord-010092-uftc8inx 11127 4 of of IN cord-010092-uftc8inx 11127 5 bacterial bacterial JJ cord-010092-uftc8inx 11127 6 and/or and/or CC cord-010092-uftc8inx 11127 7 fungal fungal JJ cord-010092-uftc8inx 11127 8 infections infection NNS cord-010092-uftc8inx 11127 9 ( ( -LRB- cord-010092-uftc8inx 11127 10 i.e. i.e. FW cord-010092-uftc8inx 11127 11 clinical clinical JJ cord-010092-uftc8inx 11127 12 signs sign NNS cord-010092-uftc8inx 11127 13 of of IN cord-010092-uftc8inx 11127 14 infection infection NN cord-010092-uftc8inx 11127 15 , , , cord-010092-uftc8inx 11127 16 positive positive JJ cord-010092-uftc8inx 11127 17 cultures culture NNS cord-010092-uftc8inx 11127 18 and and CC cord-010092-uftc8inx 11127 19 radiological radiological JJ cord-010092-uftc8inx 11127 20 evidence evidence NN cord-010092-uftc8inx 11127 21 ) ) -RRB- cord-010092-uftc8inx 11127 22 and and CC cord-010092-uftc8inx 11127 23 unresponsiveness unresponsiveness NN cord-010092-uftc8inx 11127 24 to to TO cord-010092-uftc8inx 11127 25 appropriate appropriate VB cord-010092-uftc8inx 11127 26 antimicrobial antimicrobial JJ cord-010092-uftc8inx 11127 27 therapy therapy NN cord-010092-uftc8inx 11127 28 for for IN cord-010092-uftc8inx 11127 29 at at RB cord-010092-uftc8inx 11127 30 least least RBS cord-010092-uftc8inx 11127 31 48 48 CD cord-010092-uftc8inx 11127 32 h. h. NN cord-010092-uftc8inx 11127 33 Effects effect NNS cord-010092-uftc8inx 11127 34 of of IN cord-010092-uftc8inx 11127 35 clinical clinical JJ cord-010092-uftc8inx 11127 36 , , , cord-010092-uftc8inx 11127 37 microbiological microbiological JJ cord-010092-uftc8inx 11127 38 and and CC cord-010092-uftc8inx 11127 39 granulocyte granulocyte NN cord-010092-uftc8inx 11127 40 transfusion transfusion NN cord-010092-uftc8inx 11127 41 related relate VBD cord-010092-uftc8inx 11127 42 variables variable NNS cord-010092-uftc8inx 11127 43 on on IN cord-010092-uftc8inx 11127 44 infection infection NN cord-010092-uftc8inx 11127 45 - - HYPH cord-010092-uftc8inx 11127 46 related relate VBN cord-010092-uftc8inx 11127 47 mortality mortality NN cord-010092-uftc8inx 11127 48 were be VBD cord-010092-uftc8inx 11127 49 investigated investigate VBN cord-010092-uftc8inx 11127 50 . . . cord-010092-uftc8inx 11128 1 The the DT cord-010092-uftc8inx 11128 2 post post JJ cord-010092-uftc8inx 11128 3 transfusion transfusion NN cord-010092-uftc8inx 11128 4 ANC ANC NNP cord-010092-uftc8inx 11128 5 ( ( -LRB- cord-010092-uftc8inx 11128 6 within within IN cord-010092-uftc8inx 11128 7 24 24 CD cord-010092-uftc8inx 11128 8 h h NN cord-010092-uftc8inx 11128 9 ) ) -RRB- cord-010092-uftc8inx 11128 10 increased increase VBN cord-010092-uftc8inx 11128 11 significantly significantly RB cord-010092-uftc8inx 11129 1 ( ( -LRB- cord-010092-uftc8inx 11129 2 median median JJ cord-010092-uftc8inx 11129 3 value value NN cord-010092-uftc8inx 11129 4 : : : cord-010092-uftc8inx 11129 5 350 350 CD cord-010092-uftc8inx 11129 6 / / SYM cord-010092-uftc8inx 11129 7 lL lL NNP cord-010092-uftc8inx 11129 8 ) ) -RRB- cord-010092-uftc8inx 11129 9 as as IN cord-010092-uftc8inx 11129 10 compared compare VBN cord-010092-uftc8inx 11129 11 to to IN cord-010092-uftc8inx 11129 12 baseline baseline JJ cord-010092-uftc8inx 11129 13 levels level NNS cord-010092-uftc8inx 11129 14 ( ( -LRB- cord-010092-uftc8inx 11129 15 median median JJ cord-010092-uftc8inx 11129 16 value value NN cord-010092-uftc8inx 11129 17 : : : cord-010092-uftc8inx 11129 18 40 40 CD cord-010092-uftc8inx 11129 19 / / SYM cord-010092-uftc8inx 11129 20 lL ll CD cord-010092-uftc8inx 11129 21 ) ) -RRB- cord-010092-uftc8inx 11130 1 ( ( -LRB- cord-010092-uftc8inx 11130 2 P p NN cord-010092-uftc8inx 11130 3 < < XX cord-010092-uftc8inx 11130 4 0.05 0.05 CD cord-010092-uftc8inx 11130 5 ) ) -RRB- cord-010092-uftc8inx 11130 6 . . . cord-010092-uftc8inx 11131 1 Infection infection NN cord-010092-uftc8inx 11131 2 related relate VBN cord-010092-uftc8inx 11131 3 mortality mortality NN cord-010092-uftc8inx 11131 4 was be VBD cord-010092-uftc8inx 11131 5 observed observe VBN cord-010092-uftc8inx 11131 6 in in IN cord-010092-uftc8inx 11131 7 only only RB cord-010092-uftc8inx 11131 8 20 20 CD cord-010092-uftc8inx 11131 9 % % NN cord-010092-uftc8inx 11131 10 ( ( -LRB- cord-010092-uftc8inx 11131 11 3 3 CD cord-010092-uftc8inx 11131 12 out out IN cord-010092-uftc8inx 11131 13 of of IN cord-010092-uftc8inx 11131 14 15 15 CD cord-010092-uftc8inx 11131 15 ) ) -RRB- cord-010092-uftc8inx 11131 16 of of IN cord-010092-uftc8inx 11131 17 patients patient NNS cord-010092-uftc8inx 11131 18 . . . cord-010092-uftc8inx 11132 1 Patients patient NNS cord-010092-uftc8inx 11132 2 became become VBD cord-010092-uftc8inx 11132 3 afebrile afebrile JJ cord-010092-uftc8inx 11132 4 within within IN cord-010092-uftc8inx 11132 5 2 2 CD cord-010092-uftc8inx 11132 6 - - SYM cord-010092-uftc8inx 11132 7 4 4 CD cord-010092-uftc8inx 11132 8 days day NNS cord-010092-uftc8inx 11132 9 and and CC cord-010092-uftc8inx 11132 10 culture culture NN cord-010092-uftc8inx 11132 11 negative negative JJ cord-010092-uftc8inx 11132 12 within within IN cord-010092-uftc8inx 11132 13 3 3 CD cord-010092-uftc8inx 11132 14 - - SYM cord-010092-uftc8inx 11132 15 6 6 CD cord-010092-uftc8inx 11132 16 days day NNS cord-010092-uftc8inx 11132 17 after after IN cord-010092-uftc8inx 11132 18 granulocyte granulocyte NN cord-010092-uftc8inx 11132 19 transfusion transfusion NN cord-010092-uftc8inx 11132 20 . . . cord-010092-uftc8inx 11133 1 For for IN cord-010092-uftc8inx 11133 2 analysis analysis NN cord-010092-uftc8inx 11133 3 purpose purpose NN cord-010092-uftc8inx 11133 4 granulocyte granulocyte NN cord-010092-uftc8inx 11133 5 transfusion transfusion NN cord-010092-uftc8inx 11133 6 episodes episode NNS cord-010092-uftc8inx 11133 7 were be VBD cord-010092-uftc8inx 11133 8 grouped group VBN cord-010092-uftc8inx 11133 9 according accord VBG cord-010092-uftc8inx 11133 10 to to IN cord-010092-uftc8inx 11133 11 doses dose NNS cord-010092-uftc8inx 11133 12 of of IN cord-010092-uftc8inx 11133 13 granulocyte granulocyte NN cord-010092-uftc8inx 11133 14 transfusions transfusion NNS cord-010092-uftc8inx 11133 15 , , , cord-010092-uftc8inx 11133 16 based base VBN cord-010092-uftc8inx 11133 17 on on IN cord-010092-uftc8inx 11133 18 European european JJ cord-010092-uftc8inx 11133 19 guidelines guideline NNS cord-010092-uftc8inx 11133 20 ( ( -LRB- cord-010092-uftc8inx 11133 21 standard standard JJ cord-010092-uftc8inx 11133 22 dose dose NN cord-010092-uftc8inx 11133 23 : : : cord-010092-uftc8inx 11133 24 1.5 1.5 CD cord-010092-uftc8inx 11133 25 - - SYM cord-010092-uftc8inx 11133 26 3.0 3.0 CD cord-010092-uftc8inx 11133 27 9 9 CD cord-010092-uftc8inx 11133 28 10 10 CD cord-010092-uftc8inx 11133 29 8 8 CD cord-010092-uftc8inx 11133 30 cells cell NNS cord-010092-uftc8inx 11133 31 / / SYM cord-010092-uftc8inx 11133 32 kg kg NNS cord-010092-uftc8inx 11133 33 and and CC cord-010092-uftc8inx 11133 34 high high JJ cord-010092-uftc8inx 11133 35 dose dose NN cord-010092-uftc8inx 11133 36 : : : cord-010092-uftc8inx 11133 37 > > XX cord-010092-uftc8inx 11134 1 3.0 3.0 CD cord-010092-uftc8inx 11134 2 9 9 CD cord-010092-uftc8inx 11134 3 10 10 CD cord-010092-uftc8inx 11134 4 8 8 CD cord-010092-uftc8inx 11134 5 cells cell NNS cord-010092-uftc8inx 11134 6 / / SYM cord-010092-uftc8inx 11134 7 kg kg NN cord-010092-uftc8inx 11134 8 Background background NN cord-010092-uftc8inx 11134 9 : : : cord-010092-uftc8inx 11135 1 HSA HSA NNP cord-010092-uftc8inx 11135 2 's 's POS cord-010092-uftc8inx 11135 3 Blood Blood NNP cord-010092-uftc8inx 11135 4 Services Services NNPS cord-010092-uftc8inx 11135 5 Group Group NNP cord-010092-uftc8inx 11135 6 ( ( -LRB- cord-010092-uftc8inx 11135 7 BSG BSG NNP cord-010092-uftc8inx 11135 8 ) ) -RRB- cord-010092-uftc8inx 11135 9 is be VBZ cord-010092-uftc8inx 11135 10 Singapore Singapore NNP cord-010092-uftc8inx 11135 11 's 's POS cord-010092-uftc8inx 11135 12 National National NNP cord-010092-uftc8inx 11135 13 Blood Blood NNP cord-010092-uftc8inx 11135 14 Service Service NNP cord-010092-uftc8inx 11135 15 . . . cord-010092-uftc8inx 11136 1 In in IN cord-010092-uftc8inx 11136 2 2016 2016 CD cord-010092-uftc8inx 11136 3 , , , cord-010092-uftc8inx 11136 4 we -PRON- PRP cord-010092-uftc8inx 11136 5 conducted conduct VBD cord-010092-uftc8inx 11136 6 our -PRON- PRP$ cord-010092-uftc8inx 11136 7 pilot pilot NN cord-010092-uftc8inx 11136 8 National National NNP cord-010092-uftc8inx 11136 9 PBM PBM NNP cord-010092-uftc8inx 11136 10 Audit Audit NNP cord-010092-uftc8inx 11136 11 to to TO cord-010092-uftc8inx 11136 12 promote promote VB cord-010092-uftc8inx 11136 13 PBM PBM NNP cord-010092-uftc8inx 11136 14 practices practice NNS cord-010092-uftc8inx 11136 15 . . . cord-010092-uftc8inx 11137 1 It -PRON- PRP cord-010092-uftc8inx 11137 2 was be VBD cord-010092-uftc8inx 11137 3 agreed agree VBN cord-010092-uftc8inx 11137 4 that that IN cord-010092-uftc8inx 11137 5 the the DT cord-010092-uftc8inx 11137 6 audit audit NN cord-010092-uftc8inx 11137 7 would would MD cord-010092-uftc8inx 11137 8 be be VB cord-010092-uftc8inx 11137 9 performed perform VBN cord-010092-uftc8inx 11137 10 annually annually RB cord-010092-uftc8inx 11137 11 with with IN cord-010092-uftc8inx 11137 12 incorporation incorporation NN cord-010092-uftc8inx 11137 13 of of IN cord-010092-uftc8inx 11137 14 a a DT cord-010092-uftc8inx 11137 15 new new JJ cord-010092-uftc8inx 11137 16 indicator indicator NN cord-010092-uftc8inx 11137 17 to to TO cord-010092-uftc8inx 11137 18 continue continue VB cord-010092-uftc8inx 11137 19 promotion promotion NN cord-010092-uftc8inx 11137 20 of of IN cord-010092-uftc8inx 11137 21 PBM PBM NNP cord-010092-uftc8inx 11137 22 and and CC cord-010092-uftc8inx 11137 23 sharing sharing NN cord-010092-uftc8inx 11137 24 of of IN cord-010092-uftc8inx 11137 25 good good JJ cord-010092-uftc8inx 11137 26 practices practice NNS cord-010092-uftc8inx 11137 27 . . . cord-010092-uftc8inx 11138 1 Aims aim VBZ cord-010092-uftc8inx 11138 2 : : : cord-010092-uftc8inx 11139 1 To to TO cord-010092-uftc8inx 11139 2 provide provide VB cord-010092-uftc8inx 11139 3 an an DT cord-010092-uftc8inx 11139 4 update update NN cord-010092-uftc8inx 11139 5 on on IN cord-010092-uftc8inx 11139 6 the the DT cord-010092-uftc8inx 11139 7 second second JJ cord-010092-uftc8inx 11139 8 National National NNP cord-010092-uftc8inx 11139 9 PBM PBM NNP cord-010092-uftc8inx 11139 10 Audit Audit NNP cord-010092-uftc8inx 11139 11 for for IN cord-010092-uftc8inx 11139 12 2017 2017 CD cord-010092-uftc8inx 11139 13 . . . cord-010092-uftc8inx 11140 1 Results result NNS cord-010092-uftc8inx 11140 2 are be VBP cord-010092-uftc8inx 11140 3 compared compare VBN cord-010092-uftc8inx 11140 4 to to IN cord-010092-uftc8inx 11140 5 the the DT cord-010092-uftc8inx 11140 6 pilot pilot NN cord-010092-uftc8inx 11140 7 audit audit NN cord-010092-uftc8inx 11140 8 and and CC cord-010092-uftc8inx 11140 9 summarized summarize VBD cord-010092-uftc8inx 11140 10 below below RB cord-010092-uftc8inx 11140 11 . . . cord-010092-uftc8inx 11141 1 Methods method NNS cord-010092-uftc8inx 11141 2 : : : cord-010092-uftc8inx 11141 3 We -PRON- PRP cord-010092-uftc8inx 11141 4 collected collect VBD cord-010092-uftc8inx 11141 5 data datum NNS cord-010092-uftc8inx 11141 6 on on IN cord-010092-uftc8inx 11141 7 3 3 CD cord-010092-uftc8inx 11141 8 performance performance NN cord-010092-uftc8inx 11141 9 indicators indicator NNS cord-010092-uftc8inx 11141 10 from from IN cord-010092-uftc8inx 11141 11 7 7 CD cord-010092-uftc8inx 11141 12 acute acute JJ cord-010092-uftc8inx 11141 13 public public JJ cord-010092-uftc8inx 11141 14 care care NN cord-010092-uftc8inx 11141 15 hospitals hospital NNS cord-010092-uftc8inx 11141 16 for for IN cord-010092-uftc8inx 11141 17 4 4 CD cord-010092-uftc8inx 11141 18 weeks week NNS cord-010092-uftc8inx 11141 19 each each DT cord-010092-uftc8inx 11141 20 in in IN cord-010092-uftc8inx 11141 21 March March NNP cord-010092-uftc8inx 11141 22 and and CC cord-010092-uftc8inx 11141 23 August August NNP cord-010092-uftc8inx 11141 24 2017 2017 CD cord-010092-uftc8inx 11142 1 ( ( -LRB- cord-010092-uftc8inx 11142 2 the the DT cord-010092-uftc8inx 11142 3 pilot pilot NN cord-010092-uftc8inx 11142 4 audit audit NN cord-010092-uftc8inx 11142 5 covered cover VBD cord-010092-uftc8inx 11142 6 2 2 CD cord-010092-uftc8inx 11142 7 weeks week NNS cord-010092-uftc8inx 11142 8 in in IN cord-010092-uftc8inx 11142 9 2016 2016 CD cord-010092-uftc8inx 11142 10 ) ) -RRB- cord-010092-uftc8inx 11142 11 . . . cord-010092-uftc8inx 11143 1 The the DT cord-010092-uftc8inx 11143 2 performance performance NN cord-010092-uftc8inx 11143 3 indicators indicator NNS cord-010092-uftc8inx 11143 4 were be VBD cord-010092-uftc8inx 11143 5 : : : cord-010092-uftc8inx 11143 6 1 1 LS cord-010092-uftc8inx 11143 7 ) ) -RRB- cord-010092-uftc8inx 11143 8 . . . cord-010092-uftc8inx 11144 1 Percentage percentage NN cord-010092-uftc8inx 11144 2 compliance compliance NN cord-010092-uftc8inx 11144 3 to to IN cord-010092-uftc8inx 11144 4 documentation documentation NN cord-010092-uftc8inx 11144 5 of of IN cord-010092-uftc8inx 11144 6 red red JJ cord-010092-uftc8inx 11144 7 blood blood NN cord-010092-uftc8inx 11144 8 cell cell NN cord-010092-uftc8inx 11144 9 transfusion transfusion NN cord-010092-uftc8inx 11144 10 indications indication NNS cord-010092-uftc8inx 11144 11 2 2 CD cord-010092-uftc8inx 11144 12 ) ) -RRB- cord-010092-uftc8inx 11144 13 . . . cord-010092-uftc8inx 11145 1 Percentage percentage NN cord-010092-uftc8inx 11145 2 of of IN cord-010092-uftc8inx 11145 3 patients patient NNS cord-010092-uftc8inx 11145 4 screened screen VBN cord-010092-uftc8inx 11145 5 for for IN cord-010092-uftc8inx 11145 6 pre pre JJ cord-010092-uftc8inx 11145 7 - - JJ cord-010092-uftc8inx 11145 8 operative operative JJ cord-010092-uftc8inx 11145 9 anaemia anaemia NN cord-010092-uftc8inx 11145 10 , , , cord-010092-uftc8inx 11145 11 14 14 CD cord-010092-uftc8inx 11145 12 to to TO cord-010092-uftc8inx 11145 13 45 45 CD cord-010092-uftc8inx 11145 14 days day NNS cord-010092-uftc8inx 11145 15 before before IN cord-010092-uftc8inx 11145 16 surgery surgery NN cord-010092-uftc8inx 11145 17 3 3 CD cord-010092-uftc8inx 11145 18 ) ) -RRB- cord-010092-uftc8inx 11145 19 . . . cord-010092-uftc8inx 11146 1 Peri peri JJ cord-010092-uftc8inx 11146 2 - - HYPH cord-010092-uftc8inx 11146 3 operative operative JJ cord-010092-uftc8inx 11146 4 transfusion transfusion NN cord-010092-uftc8inx 11146 5 rates rate NNS cord-010092-uftc8inx 11146 6 ( ( -LRB- cord-010092-uftc8inx 11146 7 3 3 CD cord-010092-uftc8inx 11146 8 days day NNS cord-010092-uftc8inx 11146 9 before before RB cord-010092-uftc8inx 11146 10 to to IN cord-010092-uftc8inx 11146 11 3 3 CD cord-010092-uftc8inx 11146 12 days day NNS cord-010092-uftc8inx 11146 13 after after IN cord-010092-uftc8inx 11146 14 surgery surgery NN cord-010092-uftc8inx 11146 15 ) ) -RRB- cord-010092-uftc8inx 11146 16 for for IN cord-010092-uftc8inx 11146 17 6 6 CD cord-010092-uftc8inx 11146 18 commonly commonly RB cord-010092-uftc8inx 11146 19 performed perform VBN cord-010092-uftc8inx 11146 20 surgeries surgery NNS cord-010092-uftc8inx 11146 21 : : : cord-010092-uftc8inx 11147 1 coronary coronary JJ cord-010092-uftc8inx 11147 2 artery artery NN cord-010092-uftc8inx 11147 3 bypass bypass NN cord-010092-uftc8inx 11147 4 graft graft NN cord-010092-uftc8inx 11147 5 surgery surgery NN cord-010092-uftc8inx 11147 6 ( ( -LRB- cord-010092-uftc8inx 11147 7 CABG CABG NNP cord-010092-uftc8inx 11147 8 ) ) -RRB- cord-010092-uftc8inx 11147 9 , , , cord-010092-uftc8inx 11147 10 total total JJ cord-010092-uftc8inx 11147 11 knee knee NN cord-010092-uftc8inx 11147 12 replacement replacement NN cord-010092-uftc8inx 11147 13 ( ( -LRB- cord-010092-uftc8inx 11147 14 TKR TKR NNP cord-010092-uftc8inx 11147 15 ) ) -RRB- cord-010092-uftc8inx 11147 16 , , , cord-010092-uftc8inx 11147 17 total total JJ cord-010092-uftc8inx 11147 18 hip hip NN cord-010092-uftc8inx 11147 19 replacement replacement NN cord-010092-uftc8inx 11147 20 ( ( -LRB- cord-010092-uftc8inx 11147 21 THR THR NNP cord-010092-uftc8inx 11147 22 ) ) -RRB- cord-010092-uftc8inx 11147 23 , , , cord-010092-uftc8inx 11147 24 nephrectomy nephrectomy NN cord-010092-uftc8inx 11147 25 , , , cord-010092-uftc8inx 11147 26 colectomy colectomy NN cord-010092-uftc8inx 11147 27 and and CC cord-010092-uftc8inx 11147 28 hysterectomy hysterectomy NN cord-010092-uftc8inx 11147 29 . . . cord-010092-uftc8inx 11148 1 The the DT cord-010092-uftc8inx 11148 2 first first JJ cord-010092-uftc8inx 11148 3 two two CD cord-010092-uftc8inx 11148 4 indicators indicator NNS cord-010092-uftc8inx 11148 5 assess assess VBP cord-010092-uftc8inx 11148 6 PBM PBM NNP cord-010092-uftc8inx 11148 7 efforts effort NNS cord-010092-uftc8inx 11148 8 and and CC cord-010092-uftc8inx 11148 9 were be VBD cord-010092-uftc8inx 11148 10 measured measure VBN cord-010092-uftc8inx 11148 11 in in IN cord-010092-uftc8inx 11148 12 the the DT cord-010092-uftc8inx 11148 13 pilot pilot NN cord-010092-uftc8inx 11148 14 audit audit NN cord-010092-uftc8inx 11148 15 . . . cord-010092-uftc8inx 11149 1 Indicator Indicator NNP cord-010092-uftc8inx 11149 2 3 3 CD cord-010092-uftc8inx 11149 3 ) ) -RRB- cord-010092-uftc8inx 11149 4 was be VBD cord-010092-uftc8inx 11149 5 added add VBN cord-010092-uftc8inx 11149 6 to to IN cord-010092-uftc8inx 11149 7 the the DT cord-010092-uftc8inx 11149 8 second second JJ cord-010092-uftc8inx 11149 9 audit audit NN cord-010092-uftc8inx 11149 10 to to TO cord-010092-uftc8inx 11149 11 assess assess VB cord-010092-uftc8inx 11149 12 impact impact NN cord-010092-uftc8inx 11149 13 of of IN cord-010092-uftc8inx 11149 14 PBM PBM NNP cord-010092-uftc8inx 11149 15 practices practice NNS cord-010092-uftc8inx 11149 16 on on IN cord-010092-uftc8inx 11149 17 transfusion transfusion NN cord-010092-uftc8inx 11149 18 in in IN cord-010092-uftc8inx 11149 19 surgical surgical JJ cord-010092-uftc8inx 11149 20 patients patient NNS cord-010092-uftc8inx 11149 21 . . . cord-010092-uftc8inx 11150 1 It -PRON- PRP cord-010092-uftc8inx 11150 2 was be VBD cord-010092-uftc8inx 11150 3 an an DT cord-010092-uftc8inx 11150 4 appropriate appropriate JJ cord-010092-uftc8inx 11150 5 time time NN cord-010092-uftc8inx 11150 6 to to TO cord-010092-uftc8inx 11150 7 incorporate incorporate VB cord-010092-uftc8inx 11150 8 this this DT cord-010092-uftc8inx 11150 9 indicator indicator NN cord-010092-uftc8inx 11150 10 as as IN cord-010092-uftc8inx 11150 11 the the DT cord-010092-uftc8inx 11150 12 hospitals hospital NNS cord-010092-uftc8inx 11150 13 would would MD cord-010092-uftc8inx 11150 14 have have VB cord-010092-uftc8inx 11150 15 been be VBN cord-010092-uftc8inx 11150 16 familiar familiar JJ cord-010092-uftc8inx 11150 17 with with IN cord-010092-uftc8inx 11150 18 PBM PBM NNP cord-010092-uftc8inx 11150 19 since since IN cord-010092-uftc8inx 11150 20 its -PRON- PRP$ cord-010092-uftc8inx 11150 21 introduction introduction NN cord-010092-uftc8inx 11150 22 in in IN cord-010092-uftc8inx 11150 23 2012 2012 CD cord-010092-uftc8inx 11150 24 . . . cord-010092-uftc8inx 11151 1 Results result NNS cord-010092-uftc8inx 11151 2 and and CC cord-010092-uftc8inx 11151 3 recommendations recommendation NNS cord-010092-uftc8inx 11151 4 were be VBD cord-010092-uftc8inx 11151 5 shared share VBN cord-010092-uftc8inx 11151 6 with with IN cord-010092-uftc8inx 11151 7 the the DT cord-010092-uftc8inx 11151 8 Senior Senior NNP cord-010092-uftc8inx 11151 9 Management Management NNP cord-010092-uftc8inx 11151 10 and and CC cord-010092-uftc8inx 11151 11 Hospital Hospital NNP cord-010092-uftc8inx 11151 12 Transfusion Transfusion NNP cord-010092-uftc8inx 11151 13 Committees Committees NNPS cord-010092-uftc8inx 11151 14 of of IN cord-010092-uftc8inx 11151 15 the the DT cord-010092-uftc8inx 11151 16 participating participate VBG cord-010092-uftc8inx 11151 17 hospitals hospital NNS cord-010092-uftc8inx 11151 18 . . . cord-010092-uftc8inx 11152 1 Results result NNS cord-010092-uftc8inx 11152 2 : : : cord-010092-uftc8inx 11153 1 For for IN cord-010092-uftc8inx 11153 2 indicator indicator NN cord-010092-uftc8inx 11153 3 1 1 CD cord-010092-uftc8inx 11153 4 ) ) -RRB- cord-010092-uftc8inx 11153 5 , , , cord-010092-uftc8inx 11153 6 2 2 CD cord-010092-uftc8inx 11153 7 hospitals hospital NNS cord-010092-uftc8inx 11153 8 had have VBD cord-010092-uftc8inx 11153 9 a a DT cord-010092-uftc8inx 11153 10 compliance compliance NN cord-010092-uftc8inx 11153 11 of of IN cord-010092-uftc8inx 11153 12 57 57 CD cord-010092-uftc8inx 11153 13 - - SYM cord-010092-uftc8inx 11153 14 61 61 CD cord-010092-uftc8inx 11153 15 % % NN cord-010092-uftc8inx 11153 16 , , , cord-010092-uftc8inx 11153 17 the the DT cord-010092-uftc8inx 11153 18 remaining remain VBG cord-010092-uftc8inx 11153 19 5 5 CD cord-010092-uftc8inx 11153 20 had have VBD cord-010092-uftc8inx 11153 21 a a DT cord-010092-uftc8inx 11153 22 compliance compliance NN cord-010092-uftc8inx 11153 23 of of IN cord-010092-uftc8inx 11153 24 90 90 CD cord-010092-uftc8inx 11153 25 - - SYM cord-010092-uftc8inx 11153 26 100 100 CD cord-010092-uftc8inx 11153 27 % % NN cord-010092-uftc8inx 11153 28 . . . cord-010092-uftc8inx 11154 1 All all DT cord-010092-uftc8inx 11154 2 7 7 CD cord-010092-uftc8inx 11154 3 hospitals hospital NNS cord-010092-uftc8inx 11154 4 incorporated incorporate VBD cord-010092-uftc8inx 11154 5 electronic electronic JJ cord-010092-uftc8inx 11154 6 blood blood NN cord-010092-uftc8inx 11154 7 ordering ordering NN cord-010092-uftc8inx 11154 8 but but CC cord-010092-uftc8inx 11154 9 the the DT cord-010092-uftc8inx 11154 10 usage usage NN cord-010092-uftc8inx 11154 11 was be VBD cord-010092-uftc8inx 11154 12 not not RB cord-010092-uftc8inx 11154 13 compulsory compulsory JJ cord-010092-uftc8inx 11154 14 in in IN cord-010092-uftc8inx 11154 15 some some DT cord-010092-uftc8inx 11154 16 . . . cord-010092-uftc8inx 11155 1 Hospitals hospital NNS cord-010092-uftc8inx 11155 2 which which WDT cord-010092-uftc8inx 11155 3 mandated mandate VBD cord-010092-uftc8inx 11155 4 electronic electronic JJ cord-010092-uftc8inx 11155 5 ordering ordering NN cord-010092-uftc8inx 11155 6 performed perform VBN cord-010092-uftc8inx 11155 7 better well RBR cord-010092-uftc8inx 11155 8 as as IN cord-010092-uftc8inx 11155 9 doctors doctor NNS cord-010092-uftc8inx 11155 10 could could MD cord-010092-uftc8inx 11155 11 only only RB cord-010092-uftc8inx 11155 12 order order VB cord-010092-uftc8inx 11155 13 blood blood NN cord-010092-uftc8inx 11155 14 products product NNS cord-010092-uftc8inx 11155 15 after after IN cord-010092-uftc8inx 11155 16 entering enter VBG cord-010092-uftc8inx 11155 17 the the DT cord-010092-uftc8inx 11155 18 transfusion transfusion NN cord-010092-uftc8inx 11155 19 indication indication NN cord-010092-uftc8inx 11155 20 . . . cord-010092-uftc8inx 11156 1 We -PRON- PRP cord-010092-uftc8inx 11156 2 saw see VBD cord-010092-uftc8inx 11156 3 compliance compliance NN cord-010092-uftc8inx 11156 4 increase increase NN cord-010092-uftc8inx 11156 5 from from IN cord-010092-uftc8inx 11156 6 75 75 CD cord-010092-uftc8inx 11156 7 % % NN cord-010092-uftc8inx 11156 8 in in IN cord-010092-uftc8inx 11156 9 2016 2016 CD cord-010092-uftc8inx 11156 10 to to TO cord-010092-uftc8inx 11156 11 100 100 CD cord-010092-uftc8inx 11156 12 % % NN cord-010092-uftc8inx 11156 13 in in IN cord-010092-uftc8inx 11156 14 a a DT cord-010092-uftc8inx 11156 15 hospital hospital NN cord-010092-uftc8inx 11156 16 that that WDT cord-010092-uftc8inx 11156 17 had have VBD cord-010092-uftc8inx 11156 18 newly newly RB cord-010092-uftc8inx 11156 19 mandated mandate VBN cord-010092-uftc8inx 11156 20 electronic electronic JJ cord-010092-uftc8inx 11156 21 ordering ordering NN cord-010092-uftc8inx 11156 22 . . . cord-010092-uftc8inx 11157 1 For for IN cord-010092-uftc8inx 11157 2 indicator indicator NN cord-010092-uftc8inx 11157 3 2 2 CD cord-010092-uftc8inx 11157 4 ) ) -RRB- cord-010092-uftc8inx 11157 5 , , , cord-010092-uftc8inx 11157 6 results result NNS cord-010092-uftc8inx 11157 7 ranged range VBD cord-010092-uftc8inx 11157 8 from from IN cord-010092-uftc8inx 11157 9 30 30 CD cord-010092-uftc8inx 11157 10 % % NN cord-010092-uftc8inx 11157 11 to to IN cord-010092-uftc8inx 11157 12 92 92 CD cord-010092-uftc8inx 11157 13 % % NN cord-010092-uftc8inx 11157 14 . . . cord-010092-uftc8inx 11158 1 2 2 CD cord-010092-uftc8inx 11158 2 hospitals hospital NNS cord-010092-uftc8inx 11158 3 made make VBD cord-010092-uftc8inx 11158 4 notable notable JJ cord-010092-uftc8inx 11158 5 improvements improvement NNS cord-010092-uftc8inx 11158 6 when when WRB cord-010092-uftc8inx 11158 7 compared compare VBN cord-010092-uftc8inx 11158 8 to to IN cord-010092-uftc8inx 11158 9 2016 2016 CD cord-010092-uftc8inx 11158 10 , , , cord-010092-uftc8inx 11158 11 achieving achieve VBG cord-010092-uftc8inx 11158 12 83 83 CD cord-010092-uftc8inx 11158 13 % % NN cord-010092-uftc8inx 11158 14 and and CC cord-010092-uftc8inx 11158 15 88 88 CD cord-010092-uftc8inx 11158 16 % % NN cord-010092-uftc8inx 11158 17 respectively respectively RB cord-010092-uftc8inx 11158 18 . . . cord-010092-uftc8inx 11159 1 They -PRON- PRP cord-010092-uftc8inx 11159 2 had have VBD cord-010092-uftc8inx 11159 3 implemented implement VBN cord-010092-uftc8inx 11159 4 pre pre JJ cord-010092-uftc8inx 11159 5 - - JJ cord-010092-uftc8inx 11159 6 operative operative JJ cord-010092-uftc8inx 11159 7 workflows workflow NNS cord-010092-uftc8inx 11159 8 screening screen VBG cord-010092-uftc8inx 11159 9 all all DT cord-010092-uftc8inx 11159 10 elective elective JJ cord-010092-uftc8inx 11159 11 surgical surgical JJ cord-010092-uftc8inx 11159 12 cases case NNS cord-010092-uftc8inx 11159 13 for for IN cord-010092-uftc8inx 11159 14 anaemia anaemia NN cord-010092-uftc8inx 11159 15 at at IN cord-010092-uftc8inx 11159 16 least least JJS cord-010092-uftc8inx 11159 17 2 2 CD cord-010092-uftc8inx 11159 18 weeks week NNS cord-010092-uftc8inx 11159 19 before before IN cord-010092-uftc8inx 11159 20 surgery surgery NN cord-010092-uftc8inx 11159 21 . . . cord-010092-uftc8inx 11160 1 One one CD cord-010092-uftc8inx 11160 2 hospital hospital NN cord-010092-uftc8inx 11160 3 also also RB cord-010092-uftc8inx 11160 4 started start VBD cord-010092-uftc8inx 11160 5 an an DT cord-010092-uftc8inx 11160 6 outpatient outpatient NN cord-010092-uftc8inx 11160 7 intravenous intravenous JJ cord-010092-uftc8inx 11160 8 iron iron NN cord-010092-uftc8inx 11160 9 service service NN cord-010092-uftc8inx 11160 10 which which WDT cord-010092-uftc8inx 11160 11 reduced reduce VBD cord-010092-uftc8inx 11160 12 pre pre JJ cord-010092-uftc8inx 11160 13 - - JJ cord-010092-uftc8inx 11160 14 operative operative JJ cord-010092-uftc8inx 11160 15 anaemia anaemia NN cord-010092-uftc8inx 11160 16 rates rate NNS cord-010092-uftc8inx 11160 17 . . . cord-010092-uftc8inx 11161 1 For for IN cord-010092-uftc8inx 11161 2 indicator indicator NN cord-010092-uftc8inx 11161 3 3 3 CD cord-010092-uftc8inx 11161 4 ) ) -RRB- cord-010092-uftc8inx 11161 5 , , , cord-010092-uftc8inx 11161 6 mean mean JJ cord-010092-uftc8inx 11161 7 number number NN cord-010092-uftc8inx 11161 8 of of IN cord-010092-uftc8inx 11161 9 transfused transfuse VBN cord-010092-uftc8inx 11161 10 units unit NNS cord-010092-uftc8inx 11161 11 for for IN cord-010092-uftc8inx 11161 12 each each DT cord-010092-uftc8inx 11161 13 surgery surgery NN cord-010092-uftc8inx 11161 14 ranged range VBD cord-010092-uftc8inx 11161 15 from from IN cord-010092-uftc8inx 11161 16 1.5 1.5 CD cord-010092-uftc8inx 11161 17 to to TO cord-010092-uftc8inx 11161 18 2.8 2.8 CD cord-010092-uftc8inx 11161 19 units unit NNS cord-010092-uftc8inx 11161 20 per per IN cord-010092-uftc8inx 11161 21 patient patient NN cord-010092-uftc8inx 11161 22 , , , cord-010092-uftc8inx 11161 23 lowest lowest RBS cord-010092-uftc8inx 11161 24 being be VBG cord-010092-uftc8inx 11161 25 THR THR NNP cord-010092-uftc8inx 11161 26 and and CC cord-010092-uftc8inx 11161 27 highest high JJS cord-010092-uftc8inx 11161 28 being be VBG cord-010092-uftc8inx 11161 29 CABG CABG NNP cord-010092-uftc8inx 11161 30 . . . cord-010092-uftc8inx 11162 1 This this DT cord-010092-uftc8inx 11162 2 suggests suggest VBZ cord-010092-uftc8inx 11162 3 that that IN cord-010092-uftc8inx 11162 4 some some DT cord-010092-uftc8inx 11162 5 transfusions transfusion NNS cord-010092-uftc8inx 11162 6 were be VBD cord-010092-uftc8inx 11162 7 potentially potentially RB cord-010092-uftc8inx 11162 8 avoidable avoidable JJ cord-010092-uftc8inx 11162 9 with with IN cord-010092-uftc8inx 11162 10 more more RBR cord-010092-uftc8inx 11162 11 robust robust JJ cord-010092-uftc8inx 11162 12 PBM PBM NNP cord-010092-uftc8inx 11162 13 practices practice NNS cord-010092-uftc8inx 11162 14 . . . cord-010092-uftc8inx 11163 1 The the DT cord-010092-uftc8inx 11163 2 rate rate NN cord-010092-uftc8inx 11163 3 of of IN cord-010092-uftc8inx 11163 4 perioperative perioperative JJ cord-010092-uftc8inx 11163 5 transfusions transfusion NNS cord-010092-uftc8inx 11163 6 was be VBD cord-010092-uftc8inx 11163 7 highest high JJS cord-010092-uftc8inx 11163 8 for for IN cord-010092-uftc8inx 11163 9 CABG CABG NNP cord-010092-uftc8inx 11163 10 at at IN cord-010092-uftc8inx 11163 11 46 46 CD cord-010092-uftc8inx 11163 12 % % NN cord-010092-uftc8inx 11163 13 and and CC cord-010092-uftc8inx 11163 14 lowest low JJS cord-010092-uftc8inx 11163 15 for for IN cord-010092-uftc8inx 11163 16 TKR TKR NNP cord-010092-uftc8inx 11163 17 at at IN cord-010092-uftc8inx 11163 18 7 7 CD cord-010092-uftc8inx 11163 19 % % NN cord-010092-uftc8inx 11163 20 . . . cord-010092-uftc8inx 11164 1 Summary Summary NNP cord-010092-uftc8inx 11164 2 / / SYM cord-010092-uftc8inx 11164 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 11164 4 : : : cord-010092-uftc8inx 11165 1 The the DT cord-010092-uftc8inx 11165 2 annual annual JJ cord-010092-uftc8inx 11165 3 National National NNP cord-010092-uftc8inx 11165 4 PBM PBM NNP cord-010092-uftc8inx 11165 5 Audit Audit NNP cord-010092-uftc8inx 11165 6 increases increase VBZ cord-010092-uftc8inx 11165 7 PBM PBM NNP cord-010092-uftc8inx 11165 8 awareness awareness NN cord-010092-uftc8inx 11165 9 , , , cord-010092-uftc8inx 11165 10 allowing allow VBG cord-010092-uftc8inx 11165 11 hospitals hospital NNS cord-010092-uftc8inx 11165 12 to to TO cord-010092-uftc8inx 11165 13 share share VB cord-010092-uftc8inx 11165 14 and and CC cord-010092-uftc8inx 11165 15 learn learn VB cord-010092-uftc8inx 11165 16 good good JJ cord-010092-uftc8inx 11165 17 practices practice NNS cord-010092-uftc8inx 11165 18 and and CC cord-010092-uftc8inx 11165 19 implement implement VB cord-010092-uftc8inx 11165 20 measurable measurable JJ cord-010092-uftc8inx 11165 21 improvements improvement NNS cord-010092-uftc8inx 11165 22 . . . cord-010092-uftc8inx 11166 1 Based base VBN cord-010092-uftc8inx 11166 2 on on IN cord-010092-uftc8inx 11166 3 this this DT cord-010092-uftc8inx 11166 4 audit audit NN cord-010092-uftc8inx 11166 5 , , , cord-010092-uftc8inx 11166 6 a a DT cord-010092-uftc8inx 11166 7 recommendation recommendation NN cord-010092-uftc8inx 11166 8 to to TO cord-010092-uftc8inx 11166 9 mandate mandate VB cord-010092-uftc8inx 11166 10 electronic electronic JJ cord-010092-uftc8inx 11166 11 ordering ordering NN cord-010092-uftc8inx 11166 12 of of IN cord-010092-uftc8inx 11166 13 blood blood NN cord-010092-uftc8inx 11166 14 products product NNS cord-010092-uftc8inx 11166 15 to to TO cord-010092-uftc8inx 11166 16 improve improve VB cord-010092-uftc8inx 11166 17 adherence adherence NN cord-010092-uftc8inx 11166 18 to to IN cord-010092-uftc8inx 11166 19 red red JJ cord-010092-uftc8inx 11166 20 cell cell NN cord-010092-uftc8inx 11166 21 transfusion transfusion NN cord-010092-uftc8inx 11166 22 indications indication NNS cord-010092-uftc8inx 11166 23 and and CC cord-010092-uftc8inx 11166 24 implementing implement VBG cord-010092-uftc8inx 11166 25 pre pre JJ cord-010092-uftc8inx 11166 26 - - JJ cord-010092-uftc8inx 11166 27 operative operative JJ cord-010092-uftc8inx 11166 28 workflows workflow NNS cord-010092-uftc8inx 11166 29 with with IN cord-010092-uftc8inx 11166 30 consideration consideration NN cord-010092-uftc8inx 11166 31 for for IN cord-010092-uftc8inx 11166 32 Intravenous Intravenous NNP cord-010092-uftc8inx 11166 33 Iron Iron NNP cord-010092-uftc8inx 11166 34 support support NN cord-010092-uftc8inx 11166 35 was be VBD cord-010092-uftc8inx 11166 36 made make VBN cord-010092-uftc8inx 11166 37 . . . cord-010092-uftc8inx 11167 1 This this DT cord-010092-uftc8inx 11167 2 audit audit NN cord-010092-uftc8inx 11167 3 was be VBD cord-010092-uftc8inx 11167 4 more more RBR cord-010092-uftc8inx 11167 5 representative representative JJ cord-010092-uftc8inx 11167 6 than than IN cord-010092-uftc8inx 11167 7 the the DT cord-010092-uftc8inx 11167 8 pilot pilot NN cord-010092-uftc8inx 11167 9 , , , cord-010092-uftc8inx 11167 10 with with IN cord-010092-uftc8inx 11167 11 a a DT cord-010092-uftc8inx 11167 12 longer long JJR cord-010092-uftc8inx 11167 13 duration duration NN cord-010092-uftc8inx 11167 14 of of IN cord-010092-uftc8inx 11167 15 data datum NNS cord-010092-uftc8inx 11167 16 collection collection NN cord-010092-uftc8inx 11167 17 and and CC cord-010092-uftc8inx 11167 18 incorporation incorporation NN cord-010092-uftc8inx 11167 19 of of IN cord-010092-uftc8inx 11167 20 indicator indicator NN cord-010092-uftc8inx 11167 21 3 3 CD cord-010092-uftc8inx 11167 22 ) ) -RRB- cord-010092-uftc8inx 11167 23 showing show VBG cord-010092-uftc8inx 11167 24 impact impact NN cord-010092-uftc8inx 11167 25 of of IN cord-010092-uftc8inx 11167 26 PBM PBM NNP cord-010092-uftc8inx 11167 27 practices practice NNS cord-010092-uftc8inx 11167 28 . . . cord-010092-uftc8inx 11168 1 Background background NN cord-010092-uftc8inx 11168 2 : : : cord-010092-uftc8inx 11169 1 Autoimmune autoimmune JJ cord-010092-uftc8inx 11169 2 haemolytic haemolytic JJ cord-010092-uftc8inx 11169 3 anaemia anaemia NN cord-010092-uftc8inx 11169 4 ( ( -LRB- cord-010092-uftc8inx 11169 5 AIHA AIHA NNP cord-010092-uftc8inx 11169 6 ) ) -RRB- cord-010092-uftc8inx 11169 7 is be VBZ cord-010092-uftc8inx 11169 8 a a DT cord-010092-uftc8inx 11169 9 decompensated decompensate VBN cord-010092-uftc8inx 11169 10 acquired acquire VBN cord-010092-uftc8inx 11169 11 haemolysis haemolysis NN cord-010092-uftc8inx 11169 12 caused cause VBN cord-010092-uftc8inx 11169 13 by by IN cord-010092-uftc8inx 11169 14 the the DT cord-010092-uftc8inx 11169 15 host host NN cord-010092-uftc8inx 11169 16 's 's POS cord-010092-uftc8inx 11169 17 immune immune JJ cord-010092-uftc8inx 11169 18 system system NN cord-010092-uftc8inx 11169 19 acting act VBG cord-010092-uftc8inx 11169 20 against against IN cord-010092-uftc8inx 11169 21 its -PRON- PRP$ cord-010092-uftc8inx 11169 22 own own JJ cord-010092-uftc8inx 11169 23 red red JJ cord-010092-uftc8inx 11169 24 cell cell NN cord-010092-uftc8inx 11169 25 antigens antigen NNS cord-010092-uftc8inx 11169 26 . . . cord-010092-uftc8inx 11170 1 AIHA AIHA NNP cord-010092-uftc8inx 11170 2 is be VBZ cord-010092-uftc8inx 11170 3 a a DT cord-010092-uftc8inx 11170 4 rare rare JJ cord-010092-uftc8inx 11170 5 disorder disorder NN cord-010092-uftc8inx 11170 6 and and CC cord-010092-uftc8inx 11170 7 although although IN cord-010092-uftc8inx 11170 8 British British NNP cord-010092-uftc8inx 11170 9 Society Society NNP cord-010092-uftc8inx 11170 10 of of IN cord-010092-uftc8inx 11170 11 Haematology Haematology NNP cord-010092-uftc8inx 11170 12 ( ( -LRB- cord-010092-uftc8inx 11170 13 BSH BSH NNP cord-010092-uftc8inx 11170 14 ) ) -RRB- cord-010092-uftc8inx 11170 15 guidelines guideline NNS cord-010092-uftc8inx 11170 16 for for IN cord-010092-uftc8inx 11170 17 diagnosis diagnosis NN cord-010092-uftc8inx 11170 18 and and CC cord-010092-uftc8inx 11170 19 treatment treatment NN cord-010092-uftc8inx 11170 20 were be VBD cord-010092-uftc8inx 11170 21 published publish VBN cord-010092-uftc8inx 11170 22 in in IN cord-010092-uftc8inx 11170 23 February February NNP cord-010092-uftc8inx 11170 24 2017 2017 CD cord-010092-uftc8inx 11170 25 , , , cord-010092-uftc8inx 11170 26 there there EX cord-010092-uftc8inx 11170 27 is be VBZ cord-010092-uftc8inx 11170 28 little little JJ cord-010092-uftc8inx 11170 29 evidence evidence NN cord-010092-uftc8inx 11170 30 for for IN cord-010092-uftc8inx 11170 31 clinical clinical JJ cord-010092-uftc8inx 11170 32 practice practice NN cord-010092-uftc8inx 11170 33 in in IN cord-010092-uftc8inx 11170 34 the the DT cord-010092-uftc8inx 11170 35 United United NNP cord-010092-uftc8inx 11170 36 Kingdom Kingdom NNP cord-010092-uftc8inx 11170 37 . . . cord-010092-uftc8inx 11171 1 Aims aim VBZ cord-010092-uftc8inx 11171 2 : : : cord-010092-uftc8inx 11172 1 To to TO cord-010092-uftc8inx 11172 2 investigate investigate VB cord-010092-uftc8inx 11172 3 the the DT cord-010092-uftc8inx 11172 4 approach approach NN cord-010092-uftc8inx 11172 5 to to IN cord-010092-uftc8inx 11172 6 the the DT cord-010092-uftc8inx 11172 7 diagnosis diagnosis NN cord-010092-uftc8inx 11172 8 , , , cord-010092-uftc8inx 11172 9 investigation investigation NN cord-010092-uftc8inx 11172 10 and and CC cord-010092-uftc8inx 11172 11 management management NN cord-010092-uftc8inx 11172 12 of of IN cord-010092-uftc8inx 11172 13 patients patient NNS cord-010092-uftc8inx 11172 14 with with IN cord-010092-uftc8inx 11172 15 autoimmune autoimmune JJ cord-010092-uftc8inx 11172 16 haemolytic haemolytic JJ cord-010092-uftc8inx 11172 17 anaemia anaemia NN cord-010092-uftc8inx 11172 18 ( ( -LRB- cord-010092-uftc8inx 11172 19 AIHA AIHA NNP cord-010092-uftc8inx 11172 20 ) ) -RRB- cord-010092-uftc8inx 11172 21 in in IN cord-010092-uftc8inx 11172 22 English English NNP cord-010092-uftc8inx 11172 23 NHS NHS NNP cord-010092-uftc8inx 11172 24 Trusts Trusts NNPS cord-010092-uftc8inx 11172 25 . . . cord-010092-uftc8inx 11173 1 Methods method NNS cord-010092-uftc8inx 11173 2 : : : cord-010092-uftc8inx 11173 3 We -PRON- PRP cord-010092-uftc8inx 11173 4 designed design VBD cord-010092-uftc8inx 11173 5 and and CC cord-010092-uftc8inx 11173 6 distributed distribute VBD cord-010092-uftc8inx 11173 7 a a DT cord-010092-uftc8inx 11173 8 survey survey NN cord-010092-uftc8inx 11173 9 to to IN cord-010092-uftc8inx 11173 10 the the DT cord-010092-uftc8inx 11173 11 clinical clinical JJ cord-010092-uftc8inx 11173 12 transfusion transfusion NN cord-010092-uftc8inx 11173 13 leads lead VBZ cord-010092-uftc8inx 11173 14 at at IN cord-010092-uftc8inx 11173 15 all all DT cord-010092-uftc8inx 11173 16 English English NNP cord-010092-uftc8inx 11173 17 NHS NHS NNP cord-010092-uftc8inx 11173 18 Trusts Trusts NNPS cord-010092-uftc8inx 11173 19 between between IN cord-010092-uftc8inx 11173 20 November November NNP cord-010092-uftc8inx 11173 21 2017 2017 CD cord-010092-uftc8inx 11173 22 and and CC cord-010092-uftc8inx 11173 23 March March NNP cord-010092-uftc8inx 11173 24 2018 2018 CD cord-010092-uftc8inx 11173 25 . . . cord-010092-uftc8inx 11174 1 The the DT cord-010092-uftc8inx 11174 2 survey survey NN cord-010092-uftc8inx 11174 3 requested request VBD cord-010092-uftc8inx 11174 4 information information NN cord-010092-uftc8inx 11174 5 on on IN cord-010092-uftc8inx 11174 6 detailed detailed JJ cord-010092-uftc8inx 11174 7 , , , cord-010092-uftc8inx 11174 8 simulated simulated JJ cord-010092-uftc8inx 11174 9 clinical clinical JJ cord-010092-uftc8inx 11174 10 scenarios scenario NNS cord-010092-uftc8inx 11174 11 . . . cord-010092-uftc8inx 11175 1 The the DT cord-010092-uftc8inx 11175 2 first first JJ cord-010092-uftc8inx 11175 3 simulated simulated JJ cord-010092-uftc8inx 11175 4 scenario scenario NN cord-010092-uftc8inx 11175 5 described describe VBD cord-010092-uftc8inx 11175 6 a a DT cord-010092-uftc8inx 11175 7 young young JJ cord-010092-uftc8inx 11175 8 patient patient NN cord-010092-uftc8inx 11175 9 with with IN cord-010092-uftc8inx 11175 10 active active JJ cord-010092-uftc8inx 11175 11 AIHA AIHA NNP cord-010092-uftc8inx 11175 12 3 3 CD cord-010092-uftc8inx 11175 13 months month NNS cord-010092-uftc8inx 11175 14 after after IN cord-010092-uftc8inx 11175 15 an an DT cord-010092-uftc8inx 11175 16 allogeneic allogeneic NN cord-010092-uftc8inx 11175 17 stem stem NN cord-010092-uftc8inx 11175 18 cell cell NN cord-010092-uftc8inx 11175 19 transplant transplant NN cord-010092-uftc8inx 11175 20 , , , cord-010092-uftc8inx 11175 21 who who WP cord-010092-uftc8inx 11175 22 has have VBZ cord-010092-uftc8inx 11175 23 received receive VBN cord-010092-uftc8inx 11175 24 multiple multiple JJ cord-010092-uftc8inx 11175 25 transfusions transfusion NNS cord-010092-uftc8inx 11175 26 in in IN cord-010092-uftc8inx 11175 27 the the DT cord-010092-uftc8inx 11175 28 last last JJ cord-010092-uftc8inx 11175 29 2 2 CD cord-010092-uftc8inx 11175 30 weeks week NNS cord-010092-uftc8inx 11175 31 and and CC cord-010092-uftc8inx 11175 32 is be VBZ cord-010092-uftc8inx 11175 33 hypotensive hypotensive JJ cord-010092-uftc8inx 11175 34 , , , cord-010092-uftc8inx 11175 35 tachycardic tachycardic JJ cord-010092-uftc8inx 11175 36 , , , cord-010092-uftc8inx 11175 37 with with IN cord-010092-uftc8inx 11175 38 a a DT cord-010092-uftc8inx 11175 39 falling fall VBG cord-010092-uftc8inx 11175 40 haemoglobin haemoglobin NN cord-010092-uftc8inx 11175 41 ( ( -LRB- cord-010092-uftc8inx 11175 42 Hb Hb NNP cord-010092-uftc8inx 11175 43 ) ) -RRB- cord-010092-uftc8inx 11175 44 , , , cord-010092-uftc8inx 11175 45 currently currently RB cord-010092-uftc8inx 11175 46 48 48 CD cord-010092-uftc8inx 11175 47 g g NN cord-010092-uftc8inx 11175 48 / / SYM cord-010092-uftc8inx 11175 49 l l NN cord-010092-uftc8inx 11175 50 . . . cord-010092-uftc8inx 11176 1 The the DT cord-010092-uftc8inx 11176 2 second second JJ cord-010092-uftc8inx 11176 3 scenario scenario NN cord-010092-uftc8inx 11176 4 describes describe VBZ cord-010092-uftc8inx 11176 5 a a DT cord-010092-uftc8inx 11176 6 young young JJ cord-010092-uftc8inx 11176 7 man man NN cord-010092-uftc8inx 11176 8 with with IN cord-010092-uftc8inx 11176 9 a a DT cord-010092-uftc8inx 11176 10 new new JJ cord-010092-uftc8inx 11176 11 diagnosis diagnosis NN cord-010092-uftc8inx 11176 12 of of IN cord-010092-uftc8inx 11176 13 warm warm JJ cord-010092-uftc8inx 11176 14 AIHA AIHA NNP cord-010092-uftc8inx 11176 15 who who WP cord-010092-uftc8inx 11176 16 has have VBZ cord-010092-uftc8inx 11176 17 an an DT cord-010092-uftc8inx 11176 18 initial initial JJ cord-010092-uftc8inx 11176 19 Hb Hb NNP cord-010092-uftc8inx 11176 20 of of IN cord-010092-uftc8inx 11176 21 104 104 CD cord-010092-uftc8inx 11176 22 g g NN cord-010092-uftc8inx 11176 23 / / SYM cord-010092-uftc8inx 11176 24 l l NN cord-010092-uftc8inx 11176 25 and and CC cord-010092-uftc8inx 11176 26 returns return VBZ cord-010092-uftc8inx 11176 27 to to TO cord-010092-uftc8inx 11176 28 clinic clinic VB cord-010092-uftc8inx 11176 29 at at IN cord-010092-uftc8inx 11176 30 a a DT cord-010092-uftc8inx 11176 31 2-week 2-week CD cord-010092-uftc8inx 11176 32 interval interval NN cord-010092-uftc8inx 11176 33 with with IN cord-010092-uftc8inx 11176 34 symptoms symptom NNS cord-010092-uftc8inx 11176 35 of of IN cord-010092-uftc8inx 11176 36 fatigue fatigue NN cord-010092-uftc8inx 11176 37 . . . cord-010092-uftc8inx 11177 1 He -PRON- PRP cord-010092-uftc8inx 11177 2 is be VBZ cord-010092-uftc8inx 11177 3 actively actively RB cord-010092-uftc8inx 11177 4 haemolysing haemolyse VBG cord-010092-uftc8inx 11177 5 and and CC cord-010092-uftc8inx 11177 6 commenced commence VBD cord-010092-uftc8inx 11177 7 on on IN cord-010092-uftc8inx 11177 8 1 1 CD cord-010092-uftc8inx 11177 9 mg mg NNP cord-010092-uftc8inx 11177 10 / / SYM cord-010092-uftc8inx 11177 11 kg kg NNP cord-010092-uftc8inx 11177 12 prednisolone prednisolone NN cord-010092-uftc8inx 11177 13 . . . cord-010092-uftc8inx 11178 1 Results result NNS cord-010092-uftc8inx 11178 2 : : : cord-010092-uftc8inx 11179 1 There there EX cord-010092-uftc8inx 11179 2 was be VBD cord-010092-uftc8inx 11179 3 a a DT cord-010092-uftc8inx 11179 4 42 42 CD cord-010092-uftc8inx 11179 5 % % NN cord-010092-uftc8inx 11179 6 ( ( -LRB- cord-010092-uftc8inx 11179 7 58/137 58/137 CD cord-010092-uftc8inx 11179 8 ) ) -RRB- cord-010092-uftc8inx 11179 9 response response NN cord-010092-uftc8inx 11179 10 rate rate NN cord-010092-uftc8inx 11179 11 by by IN cord-010092-uftc8inx 11179 12 Trusts trust NNS cord-010092-uftc8inx 11179 13 . . . cord-010092-uftc8inx 11180 1 Faced face VBN cord-010092-uftc8inx 11180 2 with with IN cord-010092-uftc8inx 11180 3 a a DT cord-010092-uftc8inx 11180 4 4 4 CD cord-010092-uftc8inx 11180 5 - - SYM cord-010092-uftc8inx 11180 6 6 6 CD cord-010092-uftc8inx 11180 7 h h NN cord-010092-uftc8inx 11180 8 delay delay NN cord-010092-uftc8inx 11180 9 for for IN cord-010092-uftc8inx 11180 10 allo allo NN cord-010092-uftc8inx 11180 11 - - HYPH cord-010092-uftc8inx 11180 12 adsorption adsorption NN cord-010092-uftc8inx 11180 13 studies study NNS cord-010092-uftc8inx 11180 14 , , , cord-010092-uftc8inx 11180 15 68 68 CD cord-010092-uftc8inx 11180 16 % % NN cord-010092-uftc8inx 11180 17 ( ( -LRB- cord-010092-uftc8inx 11180 18 38/56 38/56 CD cord-010092-uftc8inx 11180 19 ) ) -RRB- cord-010092-uftc8inx 11180 20 of of IN cord-010092-uftc8inx 11180 21 respondents respondent NNS cord-010092-uftc8inx 11180 22 would would MD cord-010092-uftc8inx 11180 23 instead instead RB cord-010092-uftc8inx 11180 24 transfuse transfuse VB cord-010092-uftc8inx 11180 25 acutely acutely RB cord-010092-uftc8inx 11180 26 with with IN cord-010092-uftc8inx 11180 27 ABO ABO NNP cord-010092-uftc8inx 11180 28 , , , cord-010092-uftc8inx 11180 29 Rh Rh NNP cord-010092-uftc8inx 11180 30 and and CC cord-010092-uftc8inx 11180 31 K K NNP cord-010092-uftc8inx 11180 32 matched match VBD cord-010092-uftc8inx 11180 33 red red JJ cord-010092-uftc8inx 11180 34 cells cell NNS cord-010092-uftc8inx 11180 35 negative negative JJ cord-010092-uftc8inx 11180 36 for for IN cord-010092-uftc8inx 11180 37 any any DT cord-010092-uftc8inx 11180 38 previously previously RB cord-010092-uftc8inx 11180 39 detected detect VBN cord-010092-uftc8inx 11180 40 alloantibodies alloantibody NNS cord-010092-uftc8inx 11180 41 , , , cord-010092-uftc8inx 11180 42 7 7 CD cord-010092-uftc8inx 11180 43 % % NN cord-010092-uftc8inx 11180 44 ( ( -LRB- cord-010092-uftc8inx 11180 45 4/56 4/56 CD cord-010092-uftc8inx 11180 46 ) ) -RRB- cord-010092-uftc8inx 11180 47 would would MD cord-010092-uftc8inx 11180 48 transfuse transfuse VB cord-010092-uftc8inx 11180 49 with with IN cord-010092-uftc8inx 11180 50 O o UH cord-010092-uftc8inx 11180 51 Rh rh NN cord-010092-uftc8inx 11180 52 D D NNP cord-010092-uftc8inx 11180 53 negative negative JJ cord-010092-uftc8inx 11180 54 red red JJ cord-010092-uftc8inx 11180 55 cells cell NNS cord-010092-uftc8inx 11180 56 and and CC cord-010092-uftc8inx 11180 57 25 25 CD cord-010092-uftc8inx 11180 58 % % NN cord-010092-uftc8inx 11180 59 ( ( -LRB- cord-010092-uftc8inx 11180 60 14/56 14/56 CD cord-010092-uftc8inx 11180 61 ) ) -RRB- cord-010092-uftc8inx 11180 62 would would MD cord-010092-uftc8inx 11180 63 wait wait VB cord-010092-uftc8inx 11180 64 for for IN cord-010092-uftc8inx 11180 65 completion completion NN cord-010092-uftc8inx 11180 66 of of IN cord-010092-uftc8inx 11180 67 allo allo NN cord-010092-uftc8inx 11180 68 - - HYPH cord-010092-uftc8inx 11180 69 adsorption adsorption NN cord-010092-uftc8inx 11180 70 studies study NNS cord-010092-uftc8inx 11180 71 before before IN cord-010092-uftc8inx 11180 72 transfusing transfuse VBG cord-010092-uftc8inx 11180 73 . . . cord-010092-uftc8inx 11181 1 In in IN cord-010092-uftc8inx 11181 2 this this DT cord-010092-uftc8inx 11181 3 first first JJ cord-010092-uftc8inx 11181 4 scenario scenario NN cord-010092-uftc8inx 11181 5 , , , cord-010092-uftc8inx 11181 6 a a DT cord-010092-uftc8inx 11181 7 quarter quarter NN cord-010092-uftc8inx 11181 8 of of IN cord-010092-uftc8inx 11181 9 respondents respondent NNS cord-010092-uftc8inx 11181 10 appeared appear VBD cord-010092-uftc8inx 11181 11 to to TO cord-010092-uftc8inx 11181 12 delay delay VB cord-010092-uftc8inx 11181 13 a a DT cord-010092-uftc8inx 11181 14 potentially potentially RB cord-010092-uftc8inx 11181 15 lifesaving lifesaving JJ cord-010092-uftc8inx 11181 16 blood blood NN cord-010092-uftc8inx 11181 17 transfusion transfusion NN cord-010092-uftc8inx 11181 18 . . . cord-010092-uftc8inx 11182 1 2017 2017 CD cord-010092-uftc8inx 11183 1 British British NNP cord-010092-uftc8inx 11183 2 Society Society NNP cord-010092-uftc8inx 11183 3 of of IN cord-010092-uftc8inx 11183 4 Haematology Haematology NNP cord-010092-uftc8inx 11183 5 guidelines guideline NNS cord-010092-uftc8inx 11183 6 recommend recommend VBP cord-010092-uftc8inx 11183 7 that that IN cord-010092-uftc8inx 11183 8 when when WRB cord-010092-uftc8inx 11183 9 anaemia anaemia NN cord-010092-uftc8inx 11183 10 is be VBZ cord-010092-uftc8inx 11183 11 life life NN cord-010092-uftc8inx 11183 12 - - HYPH cord-010092-uftc8inx 11183 13 threatening threaten VBG cord-010092-uftc8inx 11183 14 in in IN cord-010092-uftc8inx 11183 15 the the DT cord-010092-uftc8inx 11183 16 time time NN cord-010092-uftc8inx 11183 17 required require VBN cord-010092-uftc8inx 11183 18 for for IN cord-010092-uftc8inx 11183 19 full full JJ cord-010092-uftc8inx 11183 20 compatibility compatibility NN cord-010092-uftc8inx 11183 21 testing testing NN cord-010092-uftc8inx 11183 22 , , , cord-010092-uftc8inx 11183 23 ABO ABO NNP cord-010092-uftc8inx 11183 24 , , , cord-010092-uftc8inx 11183 25 Rh Rh NNP cord-010092-uftc8inx 11183 26 and and CC cord-010092-uftc8inx 11183 27 K K NNP cord-010092-uftc8inx 11183 28 matched match VBD cord-010092-uftc8inx 11183 29 red red JJ cord-010092-uftc8inx 11183 30 cells cell NNS cord-010092-uftc8inx 11183 31 should should MD cord-010092-uftc8inx 11183 32 be be VB cord-010092-uftc8inx 11183 33 transfused transfuse VBN cord-010092-uftc8inx 11183 34 . . . cord-010092-uftc8inx 11184 1 In in IN cord-010092-uftc8inx 11184 2 the the DT cord-010092-uftc8inx 11184 3 2017 2017 CD cord-010092-uftc8inx 11184 4 Serious serious JJ cord-010092-uftc8inx 11184 5 Hazards Hazards NNPS cord-010092-uftc8inx 11184 6 of of IN cord-010092-uftc8inx 11184 7 Transfusion Transfusion NNP cord-010092-uftc8inx 11184 8 ( ( -LRB- cord-010092-uftc8inx 11184 9 SHOT SHOT NNP cord-010092-uftc8inx 11184 10 ) ) -RRB- cord-010092-uftc8inx 11184 11 report report NN cord-010092-uftc8inx 11184 12 , , , cord-010092-uftc8inx 11184 13 the the DT cord-010092-uftc8inx 11184 14 most most RBS cord-010092-uftc8inx 11184 15 serious serious JJ cord-010092-uftc8inx 11184 16 and and CC cord-010092-uftc8inx 11184 17 fatal fatal JJ cord-010092-uftc8inx 11184 18 of of IN cord-010092-uftc8inx 11184 19 95 95 CD cord-010092-uftc8inx 11184 20 cases case NNS cord-010092-uftc8inx 11184 21 of of IN cord-010092-uftc8inx 11184 22 preventable preventable JJ cord-010092-uftc8inx 11184 23 delayed delay VBN cord-010092-uftc8inx 11184 24 transfusion transfusion NN cord-010092-uftc8inx 11184 25 was be VBD cord-010092-uftc8inx 11184 26 a a DT cord-010092-uftc8inx 11184 27 patient patient NN cord-010092-uftc8inx 11184 28 with with IN cord-010092-uftc8inx 11184 29 AIHA AIHA NNP cord-010092-uftc8inx 11184 30 who who WP cord-010092-uftc8inx 11184 31 died die VBD cord-010092-uftc8inx 11184 32 untransfused untransfuse VBN cord-010092-uftc8inx 11184 33 with with IN cord-010092-uftc8inx 11184 34 an an DT cord-010092-uftc8inx 11184 35 Hb Hb NNP cord-010092-uftc8inx 11184 36 of of IN cord-010092-uftc8inx 11184 37 38 38 CD cord-010092-uftc8inx 11184 38 g g NN cord-010092-uftc8inx 11184 39 / / SYM cord-010092-uftc8inx 11184 40 l l NN cord-010092-uftc8inx 11184 41 , , , cord-010092-uftc8inx 11184 42 while while IN cord-010092-uftc8inx 11184 43 awaiting await VBG cord-010092-uftc8inx 11184 44 alloadsorption alloadsorption NN cord-010092-uftc8inx 11184 45 studies study NNS cord-010092-uftc8inx 11184 46 . . . cord-010092-uftc8inx 11185 1 A a DT cord-010092-uftc8inx 11185 2 key key JJ cord-010092-uftc8inx 11185 3 SHOT SHOT NNP cord-010092-uftc8inx 11185 4 message message NN cord-010092-uftc8inx 11185 5 was be VBD cord-010092-uftc8inx 11185 6 that that IN cord-010092-uftc8inx 11185 7 if if IN cord-010092-uftc8inx 11185 8 clinical clinical JJ cord-010092-uftc8inx 11185 9 harm harm NN cord-010092-uftc8inx 11185 10 to to IN cord-010092-uftc8inx 11185 11 patients patient NNS cord-010092-uftc8inx 11185 12 from from IN cord-010092-uftc8inx 11185 13 withholding withhold VBG cord-010092-uftc8inx 11185 14 blood blood NN cord-010092-uftc8inx 11185 15 outweighs outweighs NN cord-010092-uftc8inx 11185 16 safety safety NN cord-010092-uftc8inx 11185 17 concerns concern NNS cord-010092-uftc8inx 11185 18 over over IN cord-010092-uftc8inx 11185 19 a a DT cord-010092-uftc8inx 11185 20 possible possible JJ cord-010092-uftc8inx 11185 21 delayed delay VBN cord-010092-uftc8inx 11185 22 haemolytic haemolytic JJ cord-010092-uftc8inx 11185 23 transfusion transfusion NN cord-010092-uftc8inx 11185 24 reaction reaction NN cord-010092-uftc8inx 11185 25 , , , cord-010092-uftc8inx 11185 26 emergency emergency NN cord-010092-uftc8inx 11185 27 blood blood NN cord-010092-uftc8inx 11185 28 is be VBZ cord-010092-uftc8inx 11185 29 essential essential JJ cord-010092-uftc8inx 11185 30 and and CC cord-010092-uftc8inx 11185 31 should should MD cord-010092-uftc8inx 11185 32 be be VB cord-010092-uftc8inx 11185 33 offered offer VBN cord-010092-uftc8inx 11185 34 . . . cord-010092-uftc8inx 11186 1 The the DT cord-010092-uftc8inx 11186 2 second second JJ cord-010092-uftc8inx 11186 3 scenario scenario NN cord-010092-uftc8inx 11186 4 also also RB cord-010092-uftc8inx 11186 5 identified identify VBD cord-010092-uftc8inx 11186 6 considerable considerable JJ cord-010092-uftc8inx 11186 7 variation variation NN cord-010092-uftc8inx 11186 8 in in IN cord-010092-uftc8inx 11186 9 transfusion transfusion NN cord-010092-uftc8inx 11186 10 practice practice NN cord-010092-uftc8inx 11186 11 . . . cord-010092-uftc8inx 11187 1 It -PRON- PRP cord-010092-uftc8inx 11187 2 can can MD cord-010092-uftc8inx 11187 3 take take VB cord-010092-uftc8inx 11187 4 several several JJ cord-010092-uftc8inx 11187 5 weeks week NNS cord-010092-uftc8inx 11187 6 for for IN cord-010092-uftc8inx 11187 7 patients patient NNS cord-010092-uftc8inx 11187 8 with with IN cord-010092-uftc8inx 11187 9 AIHA AIHA NNP cord-010092-uftc8inx 11187 10 to to TO cord-010092-uftc8inx 11187 11 respond respond VB cord-010092-uftc8inx 11187 12 to to IN cord-010092-uftc8inx 11187 13 prednisolone prednisolone NN cord-010092-uftc8inx 11187 14 so so IN cord-010092-uftc8inx 11187 15 a a DT cord-010092-uftc8inx 11187 16 transfusion transfusion NN cord-010092-uftc8inx 11187 17 threshold threshold NN cord-010092-uftc8inx 11187 18 < < XX cord-010092-uftc8inx 11187 19 60 60 CD cord-010092-uftc8inx 11187 20 g g NN cord-010092-uftc8inx 11187 21 / / SYM cord-010092-uftc8inx 11187 22 l l NN cord-010092-uftc8inx 11187 23 after after IN cord-010092-uftc8inx 11187 24 an an DT cord-010092-uftc8inx 11187 25 Hb Hb NNP cord-010092-uftc8inx 11187 26 fall fall NN cord-010092-uftc8inx 11187 27 of of IN cord-010092-uftc8inx 11187 28 at at RB cord-010092-uftc8inx 11187 29 least least RBS cord-010092-uftc8inx 11187 30 40 40 CD cord-010092-uftc8inx 11187 31 g g NN cord-010092-uftc8inx 11187 32 / / SYM cord-010092-uftc8inx 11187 33 l l NN cord-010092-uftc8inx 11187 34 in in IN cord-010092-uftc8inx 11187 35 the the DT cord-010092-uftc8inx 11187 36 previous previous JJ cord-010092-uftc8inx 11187 37 2 2 CD cord-010092-uftc8inx 11187 38 weeks week NNS cord-010092-uftc8inx 11187 39 is be VBZ cord-010092-uftc8inx 11187 40 perhaps perhaps RB cord-010092-uftc8inx 11187 41 overly overly RB cord-010092-uftc8inx 11187 42 conservative conservative JJ cord-010092-uftc8inx 11187 43 . . . cord-010092-uftc8inx 11188 1 Summary Summary NNP cord-010092-uftc8inx 11188 2 / / SYM cord-010092-uftc8inx 11188 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 11188 4 : : : cord-010092-uftc8inx 11189 1 The the DT cord-010092-uftc8inx 11189 2 overall overall JJ cord-010092-uftc8inx 11189 3 findings finding NNS cord-010092-uftc8inx 11189 4 support support VBP cord-010092-uftc8inx 11189 5 a a DT cord-010092-uftc8inx 11189 6 need need NN cord-010092-uftc8inx 11189 7 for for IN cord-010092-uftc8inx 11189 8 studies study NNS cord-010092-uftc8inx 11189 9 to to TO cord-010092-uftc8inx 11189 10 explore explore VB cord-010092-uftc8inx 11189 11 barriers barrier NNS cord-010092-uftc8inx 11189 12 to to IN cord-010092-uftc8inx 11189 13 uptake uptake NN cord-010092-uftc8inx 11189 14 of of IN cord-010092-uftc8inx 11189 15 guidelines guideline NNS cord-010092-uftc8inx 11189 16 , , , cord-010092-uftc8inx 11189 17 and and CC cord-010092-uftc8inx 11189 18 to to TO cord-010092-uftc8inx 11189 19 identify identify VB cord-010092-uftc8inx 11189 20 areas area NNS cord-010092-uftc8inx 11189 21 for for IN cord-010092-uftc8inx 11189 22 further further JJ cord-010092-uftc8inx 11189 23 audit audit NN cord-010092-uftc8inx 11189 24 and and CC cord-010092-uftc8inx 11189 25 research research NN cord-010092-uftc8inx 11189 26 to to TO cord-010092-uftc8inx 11189 27 guide guide VB cord-010092-uftc8inx 11189 28 safe safe JJ cord-010092-uftc8inx 11189 29 and and CC cord-010092-uftc8inx 11189 30 appropriate appropriate JJ cord-010092-uftc8inx 11189 31 transfusion transfusion NN cord-010092-uftc8inx 11189 32 practice practice NN cord-010092-uftc8inx 11189 33 in in IN cord-010092-uftc8inx 11189 34 AIHA AIHA NNP cord-010092-uftc8inx 11189 35 . . . cord-010092-uftc8inx 11190 1 Background background NN cord-010092-uftc8inx 11190 2 : : : cord-010092-uftc8inx 11191 1 Balance balance NN cord-010092-uftc8inx 11191 2 between between IN cord-010092-uftc8inx 11191 3 supply supply NN cord-010092-uftc8inx 11191 4 and and CC cord-010092-uftc8inx 11191 5 demand demand NN cord-010092-uftc8inx 11191 6 of of IN cord-010092-uftc8inx 11191 7 O o NN cord-010092-uftc8inx 11191 8 D d NN cord-010092-uftc8inx 11191 9 negative negative JJ cord-010092-uftc8inx 11191 10 red red JJ cord-010092-uftc8inx 11191 11 cells cell NNS cord-010092-uftc8inx 11191 12 remains remain VBZ cord-010092-uftc8inx 11191 13 a a DT cord-010092-uftc8inx 11191 14 challenge challenge NN cord-010092-uftc8inx 11191 15 for for IN cord-010092-uftc8inx 11191 16 almost almost RB cord-010092-uftc8inx 11191 17 every every DT cord-010092-uftc8inx 11191 18 blood blood NN cord-010092-uftc8inx 11191 19 service service NN cord-010092-uftc8inx 11191 20 . . . cord-010092-uftc8inx 11192 1 With with IN cord-010092-uftc8inx 11192 2 this this DT cord-010092-uftc8inx 11192 3 re re NN cord-010092-uftc8inx 11192 4 - - NN cord-010092-uftc8inx 11192 5 audit audit NN cord-010092-uftc8inx 11192 6 , , , cord-010092-uftc8inx 11192 7 we -PRON- PRP cord-010092-uftc8inx 11192 8 wanted want VBD cord-010092-uftc8inx 11192 9 to to TO cord-010092-uftc8inx 11192 10 collect collect VB cord-010092-uftc8inx 11192 11 objective objective JJ cord-010092-uftc8inx 11192 12 and and CC cord-010092-uftc8inx 11192 13 comprehensive comprehensive JJ cord-010092-uftc8inx 11192 14 information information NN cord-010092-uftc8inx 11192 15 regarding regard VBG cord-010092-uftc8inx 11192 16 usage usage NN cord-010092-uftc8inx 11192 17 of of IN cord-010092-uftc8inx 11192 18 O o NN cord-010092-uftc8inx 11192 19 D d NN cord-010092-uftc8inx 11192 20 negative negative JJ cord-010092-uftc8inx 11192 21 red red JJ cord-010092-uftc8inx 11192 22 cells cell NNS cord-010092-uftc8inx 11192 23 supplied supply VBN cord-010092-uftc8inx 11192 24 by by IN cord-010092-uftc8inx 11192 25 NHS NHS NNP cord-010092-uftc8inx 11192 26 Blood Blood NNP cord-010092-uftc8inx 11192 27 and and CC cord-010092-uftc8inx 11192 28 Transplant Transplant NNP cord-010092-uftc8inx 11192 29 ( ( -LRB- cord-010092-uftc8inx 11192 30 NHSBT NHSBT NNP cord-010092-uftc8inx 11192 31 ) ) -RRB- cord-010092-uftc8inx 11192 32 to to TO cord-010092-uftc8inx 11192 33 private private JJ cord-010092-uftc8inx 11192 34 and and CC cord-010092-uftc8inx 11192 35 NHS NHS NNP cord-010092-uftc8inx 11192 36 hospitals hospital NNS cord-010092-uftc8inx 11192 37 in in IN cord-010092-uftc8inx 11192 38 England England NNP cord-010092-uftc8inx 11192 39 . . . cord-010092-uftc8inx 11193 1 Aims aim VBZ cord-010092-uftc8inx 11193 2 : : : cord-010092-uftc8inx 11194 1 The the DT cord-010092-uftc8inx 11194 2 aim aim NN cord-010092-uftc8inx 11194 3 was be VBD cord-010092-uftc8inx 11194 4 to to TO cord-010092-uftc8inx 11194 5 understand understand VB cord-010092-uftc8inx 11194 6 hospital hospital NN cord-010092-uftc8inx 11194 7 practices practice NNS cord-010092-uftc8inx 11194 8 , , , cord-010092-uftc8inx 11194 9 actual actual JJ cord-010092-uftc8inx 11194 10 needs need NNS cord-010092-uftc8inx 11194 11 and and CC cord-010092-uftc8inx 11194 12 possible possible JJ cord-010092-uftc8inx 11194 13 avoidable avoidable JJ cord-010092-uftc8inx 11194 14 usage usage NN cord-010092-uftc8inx 11194 15 of of IN cord-010092-uftc8inx 11194 16 O o NN cord-010092-uftc8inx 11194 17 D d NN cord-010092-uftc8inx 11194 18 negative negative JJ cord-010092-uftc8inx 11194 19 red red JJ cord-010092-uftc8inx 11194 20 cells cell NNS cord-010092-uftc8inx 11194 21 . . . cord-010092-uftc8inx 11195 1 Where where WRB cord-010092-uftc8inx 11195 2 possible possible JJ cord-010092-uftc8inx 11195 3 , , , cord-010092-uftc8inx 11195 4 comparisons comparison NNS cord-010092-uftc8inx 11195 5 were be VBD cord-010092-uftc8inx 11195 6 made make VBN cord-010092-uftc8inx 11195 7 with with IN cord-010092-uftc8inx 11195 8 two two CD cord-010092-uftc8inx 11195 9 previous previous JJ cord-010092-uftc8inx 11195 10 audits audits NN cord-010092-uftc8inx 11195 11 ( ( -LRB- cord-010092-uftc8inx 11195 12 2008 2008 CD cord-010092-uftc8inx 11195 13 ) ) -RRB- cord-010092-uftc8inx 11195 14 ( ( -LRB- cord-010092-uftc8inx 11195 15 2009 2009 CD cord-010092-uftc8inx 11195 16 ) ) -RRB- cord-010092-uftc8inx 11195 17 ( ( -LRB- cord-010092-uftc8inx 11195 18 2010 2010 CD cord-010092-uftc8inx 11195 19 ) ) -RRB- cord-010092-uftc8inx 11195 20 . . . cord-010092-uftc8inx 11196 1 Methods method NNS cord-010092-uftc8inx 11196 2 : : : cord-010092-uftc8inx 11196 3 Participating participate VBG cord-010092-uftc8inx 11196 4 hospitals hospital NNS cord-010092-uftc8inx 11196 5 were be VBD cord-010092-uftc8inx 11196 6 asked ask VBN cord-010092-uftc8inx 11196 7 to to TO cord-010092-uftc8inx 11196 8 determine determine VB cord-010092-uftc8inx 11196 9 the the DT cord-010092-uftc8inx 11196 10 fate fate NN cord-010092-uftc8inx 11196 11 of of IN cord-010092-uftc8inx 11196 12 all all DT cord-010092-uftc8inx 11196 13 group group NN cord-010092-uftc8inx 11196 14 O o NN cord-010092-uftc8inx 11196 15 D d NN cord-010092-uftc8inx 11196 16 negative negative JJ cord-010092-uftc8inx 11196 17 red red JJ cord-010092-uftc8inx 11196 18 cells cell NNS cord-010092-uftc8inx 11196 19 they -PRON- PRP cord-010092-uftc8inx 11196 20 received receive VBD cord-010092-uftc8inx 11196 21 between between IN cord-010092-uftc8inx 11196 22 14 14 CD cord-010092-uftc8inx 11196 23 th th XX cord-010092-uftc8inx 11196 24 and and CC cord-010092-uftc8inx 11196 25 27 27 CD cord-010092-uftc8inx 11196 26 th th XX cord-010092-uftc8inx 11196 27 May May NNP cord-010092-uftc8inx 11196 28 2018 2018 CD cord-010092-uftc8inx 11196 29 excluding exclude VBG cord-010092-uftc8inx 11196 30 substitutions substitution NNS cord-010092-uftc8inx 11196 31 and and CC cord-010092-uftc8inx 11196 32 complete complete VB cord-010092-uftc8inx 11196 33 an an DT cord-010092-uftc8inx 11196 34 organisational organisational JJ cord-010092-uftc8inx 11196 35 survey survey NN cord-010092-uftc8inx 11196 36 regarding regard VBG cord-010092-uftc8inx 11196 37 activities activity NNS cord-010092-uftc8inx 11196 38 , , , cord-010092-uftc8inx 11196 39 policies policy NNS cord-010092-uftc8inx 11196 40 and and CC cord-010092-uftc8inx 11196 41 stockholding stockholding NN cord-010092-uftc8inx 11196 42 practices practice NNS cord-010092-uftc8inx 11196 43 with with IN cord-010092-uftc8inx 11196 44 respect respect NN cord-010092-uftc8inx 11196 45 to to IN cord-010092-uftc8inx 11196 46 O o UH cord-010092-uftc8inx 11196 47 D d NN cord-010092-uftc8inx 11196 48 negative negative JJ cord-010092-uftc8inx 11196 49 blood blood NN cord-010092-uftc8inx 11196 50 . . . cord-010092-uftc8inx 11197 1 Participating participate VBG cord-010092-uftc8inx 11197 2 hospitals hospital NNS cord-010092-uftc8inx 11197 3 were be VBD cord-010092-uftc8inx 11197 4 asked ask VBN cord-010092-uftc8inx 11197 5 to to TO cord-010092-uftc8inx 11197 6 provide provide VB cord-010092-uftc8inx 11197 7 ( ( -LRB- cord-010092-uftc8inx 11197 8 if if IN cord-010092-uftc8inx 11197 9 available available JJ cord-010092-uftc8inx 11197 10 ) ) -RRB- cord-010092-uftc8inx 11197 11 the the DT cord-010092-uftc8inx 11197 12 prevalence prevalence NN cord-010092-uftc8inx 11197 13 ( ( -LRB- cord-010092-uftc8inx 11197 14 as as IN cord-010092-uftc8inx 11197 15 a a DT cord-010092-uftc8inx 11197 16 percentage percentage NN cord-010092-uftc8inx 11197 17 ) ) -RRB- cord-010092-uftc8inx 11197 18 of of IN cord-010092-uftc8inx 11197 19 O o NN cord-010092-uftc8inx 11197 20 D d NN cord-010092-uftc8inx 11197 21 negative negative JJ cord-010092-uftc8inx 11197 22 patients patient NNS cord-010092-uftc8inx 11197 23 in in IN cord-010092-uftc8inx 11197 24 their -PRON- PRP$ cord-010092-uftc8inx 11197 25 population population NN cord-010092-uftc8inx 11197 26 . . . cord-010092-uftc8inx 11198 1 This this DT cord-010092-uftc8inx 11198 2 information information NN cord-010092-uftc8inx 11198 3 , , , cord-010092-uftc8inx 11198 4 in in IN cord-010092-uftc8inx 11198 5 conjunctions conjunction NNS cord-010092-uftc8inx 11198 6 with with IN cord-010092-uftc8inx 11198 7 hospital hospital NN cord-010092-uftc8inx 11198 8 activities activity NNS cord-010092-uftc8inx 11198 9 , , , cord-010092-uftc8inx 11198 10 will will MD cord-010092-uftc8inx 11198 11 be be VB cord-010092-uftc8inx 11198 12 used use VBN cord-010092-uftc8inx 11198 13 to to TO cord-010092-uftc8inx 11198 14 estimate estimate VB cord-010092-uftc8inx 11198 15 appropriate appropriate JJ cord-010092-uftc8inx 11198 16 O o UH cord-010092-uftc8inx 11198 17 D d NN cord-010092-uftc8inx 11198 18 negative negative JJ cord-010092-uftc8inx 11198 19 stockholding stockholding NN cord-010092-uftc8inx 11198 20 levels level NNS cord-010092-uftc8inx 11198 21 . . . cord-010092-uftc8inx 11199 1 Background background NN cord-010092-uftc8inx 11199 2 : : : cord-010092-uftc8inx 11200 1 O o UH cord-010092-uftc8inx 11200 2 RhD rhd NN cord-010092-uftc8inx 11200 3 - - HYPH cord-010092-uftc8inx 11200 4 negative negative JJ cord-010092-uftc8inx 11200 5 ( ( -LRB- cord-010092-uftc8inx 11200 6 neg neg JJ cord-010092-uftc8inx 11200 7 ) ) -RRB- cord-010092-uftc8inx 11200 8 red red JJ cord-010092-uftc8inx 11200 9 blood blood NN cord-010092-uftc8inx 11200 10 cells cell NNS cord-010092-uftc8inx 11200 11 ( ( -LRB- cord-010092-uftc8inx 11200 12 RBCs rbc NNS cord-010092-uftc8inx 11200 13 ) ) -RRB- cord-010092-uftc8inx 11200 14 are be VBP cord-010092-uftc8inx 11200 15 a a DT cord-010092-uftc8inx 11200 16 precious precious JJ cord-010092-uftc8inx 11200 17 resource resource NN cord-010092-uftc8inx 11200 18 , , , cord-010092-uftc8inx 11200 19 are be VBP cord-010092-uftc8inx 11200 20 often often RB cord-010092-uftc8inx 11200 21 in in IN cord-010092-uftc8inx 11200 22 short short JJ cord-010092-uftc8inx 11200 23 supply supply NN cord-010092-uftc8inx 11200 24 and and CC cord-010092-uftc8inx 11200 25 transfusion transfusion NN cord-010092-uftc8inx 11200 26 of of IN cord-010092-uftc8inx 11200 27 these these DT cord-010092-uftc8inx 11200 28 units unit NNS cord-010092-uftc8inx 11200 29 in in IN cord-010092-uftc8inx 11200 30 emergency emergency NN cord-010092-uftc8inx 11200 31 settings setting NNS cord-010092-uftc8inx 11200 32 carries carry VBZ cord-010092-uftc8inx 11200 33 the the DT cord-010092-uftc8inx 11200 34 potential potential JJ cord-010092-uftc8inx 11200 35 risk risk NN cord-010092-uftc8inx 11200 36 of of IN cord-010092-uftc8inx 11200 37 transfusion transfusion NN cord-010092-uftc8inx 11200 38 - - HYPH cord-010092-uftc8inx 11200 39 related relate VBN cord-010092-uftc8inx 11200 40 adverse adverse JJ cord-010092-uftc8inx 11200 41 outcomes outcome NNS cord-010092-uftc8inx 11200 42 such such JJ cord-010092-uftc8inx 11200 43 as as IN cord-010092-uftc8inx 11200 44 haemolytic haemolytic JJ cord-010092-uftc8inx 11200 45 reaction reaction NN cord-010092-uftc8inx 11200 46 due due IN cord-010092-uftc8inx 11200 47 to to IN cord-010092-uftc8inx 11200 48 minor minor JJ cord-010092-uftc8inx 11200 49 blood blood NN cord-010092-uftc8inx 11200 50 group group NN cord-010092-uftc8inx 11200 51 incompatibility incompatibility NN cord-010092-uftc8inx 11200 52 . . . cord-010092-uftc8inx 11201 1 As as IN cord-010092-uftc8inx 11201 2 such such JJ cord-010092-uftc8inx 11201 3 , , , cord-010092-uftc8inx 11201 4 their -PRON- PRP$ cord-010092-uftc8inx 11201 5 use use NN cord-010092-uftc8inx 11201 6 should should MD cord-010092-uftc8inx 11201 7 be be VB cord-010092-uftc8inx 11201 8 closely closely RB cord-010092-uftc8inx 11201 9 monitored monitor VBN cord-010092-uftc8inx 11201 10 within within IN cord-010092-uftc8inx 11201 11 health health NN cord-010092-uftc8inx 11201 12 services service NNS cord-010092-uftc8inx 11201 13 . . . cord-010092-uftc8inx 11202 1 Most Most JJS cord-010092-uftc8inx 11202 2 recent recent JJ cord-010092-uftc8inx 11202 3 Australian australian JJ cord-010092-uftc8inx 11202 4 guidelines guideline NNS cord-010092-uftc8inx 11202 5 ( ( -LRB- cord-010092-uftc8inx 11202 6 2008 2008 CD cord-010092-uftc8inx 11202 7 ) ) -RRB- cord-010092-uftc8inx 11202 8 for for IN cord-010092-uftc8inx 11202 9 their -PRON- PRP$ cord-010092-uftc8inx 11202 10 use use NN cord-010092-uftc8inx 11202 11 in in IN cord-010092-uftc8inx 11202 12 emergency emergency NN cord-010092-uftc8inx 11202 13 settings setting NNS cord-010092-uftc8inx 11202 14 include include VBP cord-010092-uftc8inx 11202 15 pre pre JJ cord-010092-uftc8inx 11202 16 - - JJ cord-010092-uftc8inx 11202 17 menopausal menopausal JJ cord-010092-uftc8inx 11202 18 females female NNS cord-010092-uftc8inx 11202 19 of of IN cord-010092-uftc8inx 11202 20 unknown unknown JJ cord-010092-uftc8inx 11202 21 blood blood NN cord-010092-uftc8inx 11202 22 group group NN cord-010092-uftc8inx 11202 23 ( ( -LRB- cord-010092-uftc8inx 11202 24 mandatory mandatory JJ cord-010092-uftc8inx 11202 25 indication indication NN cord-010092-uftc8inx 11202 26 ) ) -RRB- cord-010092-uftc8inx 11202 27 or or CC cord-010092-uftc8inx 11202 28 while while IN cord-010092-uftc8inx 11202 29 the the DT cord-010092-uftc8inx 11202 30 blood blood NN cord-010092-uftc8inx 11202 31 group group NN cord-010092-uftc8inx 11202 32 is be VBZ cord-010092-uftc8inx 11202 33 being be VBG cord-010092-uftc8inx 11202 34 established establish VBN cord-010092-uftc8inx 11202 35 ; ; : cord-010092-uftc8inx 11202 36 use use NN cord-010092-uftc8inx 11202 37 should should MD cord-010092-uftc8inx 11202 38 be be VB cord-010092-uftc8inx 11202 39 limited limit VBN cord-010092-uftc8inx 11202 40 to to IN cord-010092-uftc8inx 11202 41 2 2 CD cord-010092-uftc8inx 11202 42 or or CC cord-010092-uftc8inx 11202 43 less less JJR cord-010092-uftc8inx 11202 44 units unit NNS cord-010092-uftc8inx 11202 45 where where WRB cord-010092-uftc8inx 11202 46 possible possible JJ cord-010092-uftc8inx 11202 47 before before IN cord-010092-uftc8inx 11202 48 a a DT cord-010092-uftc8inx 11202 49 switch switch NN cord-010092-uftc8inx 11202 50 to to IN cord-010092-uftc8inx 11202 51 group group NN cord-010092-uftc8inx 11202 52 - - HYPH cord-010092-uftc8inx 11202 53 specific specific JJ cord-010092-uftc8inx 11202 54 RBCs rbc NNS cord-010092-uftc8inx 11202 55 ( ( -LRB- cord-010092-uftc8inx 11202 56 acceptable acceptable JJ cord-010092-uftc8inx 11202 57 indication indication NN cord-010092-uftc8inx 11202 58 ) ) -RRB- cord-010092-uftc8inx 11202 59 . . . cord-010092-uftc8inx 11203 1 Aims aim VBZ cord-010092-uftc8inx 11203 2 : : : cord-010092-uftc8inx 11203 3 Audit audit NN cord-010092-uftc8inx 11203 4 of of IN cord-010092-uftc8inx 11203 5 use use NN cord-010092-uftc8inx 11203 6 of of IN cord-010092-uftc8inx 11204 1 emergency emergency NN cord-010092-uftc8inx 11204 2 uncrossmatched uncrossmatched JJ cord-010092-uftc8inx 11205 1 O o UH cord-010092-uftc8inx 11205 2 RhD RhD NNP cord-010092-uftc8inx 11206 1 -neg -neg : cord-010092-uftc8inx 11206 2 RBCs rbc NNS cord-010092-uftc8inx 11206 3 against against IN cord-010092-uftc8inx 11206 4 national national JJ cord-010092-uftc8inx 11206 5 guidelines guideline NNS cord-010092-uftc8inx 11206 6 in in IN cord-010092-uftc8inx 11206 7 our -PRON- PRP$ cord-010092-uftc8inx 11206 8 institution institution NN cord-010092-uftc8inx 11206 9 ( ( -LRB- cord-010092-uftc8inx 11206 10 an an DT cord-010092-uftc8inx 11206 11 Australian australian JJ cord-010092-uftc8inx 11206 12 tertiary tertiary JJ cord-010092-uftc8inx 11206 13 metropolitan metropolitan JJ cord-010092-uftc8inx 11206 14 public public JJ cord-010092-uftc8inx 11206 15 hospital hospital NN cord-010092-uftc8inx 11206 16 providing provide VBG cord-010092-uftc8inx 11206 17 acute acute JJ cord-010092-uftc8inx 11206 18 medical medical JJ cord-010092-uftc8inx 11206 19 and and CC cord-010092-uftc8inx 11206 20 surgical surgical JJ cord-010092-uftc8inx 11206 21 , , , cord-010092-uftc8inx 11206 22 emergency emergency NN cord-010092-uftc8inx 11206 23 and and CC cord-010092-uftc8inx 11206 24 critical critical JJ cord-010092-uftc8inx 11206 25 care care NN cord-010092-uftc8inx 11206 26 services service NNS cord-010092-uftc8inx 11206 27 ) ) -RRB- cord-010092-uftc8inx 11206 28 . . . cord-010092-uftc8inx 11207 1 Methods method NNS cord-010092-uftc8inx 11207 2 : : : cord-010092-uftc8inx 11207 3 Use use NN cord-010092-uftc8inx 11207 4 of of IN cord-010092-uftc8inx 11207 5 emergency emergency NN cord-010092-uftc8inx 11208 1 uncrossmatched uncrossmatched JJ cord-010092-uftc8inx 11209 1 O o UH cord-010092-uftc8inx 11209 2 RhD rhd NN cord-010092-uftc8inx 11209 3 - - HYPH cord-010092-uftc8inx 11209 4 neg neg JJ cord-010092-uftc8inx 11209 5 RBCs rbc NNS cord-010092-uftc8inx 11209 6 units unit NNS cord-010092-uftc8inx 11209 7 over over IN cord-010092-uftc8inx 11209 8 a a DT cord-010092-uftc8inx 11209 9 six six CD cord-010092-uftc8inx 11209 10 - - HYPH cord-010092-uftc8inx 11209 11 year year NN cord-010092-uftc8inx 11209 12 period period NN cord-010092-uftc8inx 11209 13 was be VBD cord-010092-uftc8inx 11209 14 retrospectively retrospectively RB cord-010092-uftc8inx 11209 15 reviewed review VBN cord-010092-uftc8inx 11209 16 . . . cord-010092-uftc8inx 11210 1 We -PRON- PRP cord-010092-uftc8inx 11210 2 collected collect VBD cord-010092-uftc8inx 11210 3 information information NN cord-010092-uftc8inx 11210 4 about about IN cord-010092-uftc8inx 11210 5 RBCs rbc NNS cord-010092-uftc8inx 11210 6 transfused transfuse VBN cord-010092-uftc8inx 11210 7 and and CC cord-010092-uftc8inx 11210 8 discarded discard VBN cord-010092-uftc8inx 11210 9 , , , cord-010092-uftc8inx 11210 10 adverse adverse JJ cord-010092-uftc8inx 11210 11 outcomes outcome NNS cord-010092-uftc8inx 11210 12 , , , cord-010092-uftc8inx 11210 13 patient patient NN cord-010092-uftc8inx 11210 14 characteristics characteristic NNS cord-010092-uftc8inx 11210 15 , , , cord-010092-uftc8inx 11210 16 clinical clinical JJ cord-010092-uftc8inx 11210 17 indications indication NNS cord-010092-uftc8inx 11210 18 and and CC cord-010092-uftc8inx 11210 19 whether whether IN cord-010092-uftc8inx 11210 20 use use NN cord-010092-uftc8inx 11210 21 met meet VBD cord-010092-uftc8inx 11210 22 national national JJ cord-010092-uftc8inx 11210 23 guidelines guideline NNS cord-010092-uftc8inx 11210 24 or or CC cord-010092-uftc8inx 11210 25 could could MD cord-010092-uftc8inx 11210 26 have have VB cord-010092-uftc8inx 11210 27 been be VBN cord-010092-uftc8inx 11210 28 avoided avoid VBN cord-010092-uftc8inx 11210 29 . . . cord-010092-uftc8inx 11211 1 Results result NNS cord-010092-uftc8inx 11211 2 : : : cord-010092-uftc8inx 11211 3 105 105 CD cord-010092-uftc8inx 11211 4 episodes episode NNS cord-010092-uftc8inx 11211 5 of of IN cord-010092-uftc8inx 11211 6 emergency emergency NN cord-010092-uftc8inx 11211 7 uncrossmatched uncrossmatched JJ cord-010092-uftc8inx 11211 8 O o NN cord-010092-uftc8inx 11211 9 RhD rhd NN cord-010092-uftc8inx 11212 1 -neg -neg : cord-010092-uftc8inx 11212 2 RBCs rbc NNS cord-010092-uftc8inx 11212 3 were be VBD cord-010092-uftc8inx 11212 4 identified identify VBN cord-010092-uftc8inx 11212 5 , , , cord-010092-uftc8inx 11212 6 encompassing encompass VBG cord-010092-uftc8inx 11212 7 transfusion transfusion NN cord-010092-uftc8inx 11212 8 of of IN cord-010092-uftc8inx 11212 9 241 241 CD cord-010092-uftc8inx 11212 10 RBC RBC NNP cord-010092-uftc8inx 11212 11 units unit NNS cord-010092-uftc8inx 11212 12 to to IN cord-010092-uftc8inx 11212 13 103 103 CD cord-010092-uftc8inx 11212 14 patients patient NNS cord-010092-uftc8inx 11212 15 and and CC cord-010092-uftc8inx 11212 16 the the DT cord-010092-uftc8inx 11212 17 discard discard NN cord-010092-uftc8inx 11212 18 of of IN cord-010092-uftc8inx 11212 19 2 2 CD cord-010092-uftc8inx 11212 20 RBCs rbc NNS cord-010092-uftc8inx 11212 21 ( ( -LRB- cord-010092-uftc8inx 11212 22 due due JJ cord-010092-uftc8inx 11212 23 to to IN cord-010092-uftc8inx 11212 24 incorrect incorrect JJ cord-010092-uftc8inx 11212 25 transport transport NN cord-010092-uftc8inx 11212 26 ) ) -RRB- cord-010092-uftc8inx 11212 27 . . . cord-010092-uftc8inx 11213 1 Of of IN cord-010092-uftc8inx 11213 2 the the DT cord-010092-uftc8inx 11213 3 105 105 CD cord-010092-uftc8inx 11213 4 episodes episode NNS cord-010092-uftc8inx 11213 5 , , , cord-010092-uftc8inx 11213 6 78 78 CD cord-010092-uftc8inx 11213 7 episodes episode NNS cord-010092-uftc8inx 11213 8 ( ( -LRB- cord-010092-uftc8inx 11213 9 74 74 CD cord-010092-uftc8inx 11213 10 % % NN cord-010092-uftc8inx 11213 11 ) ) -RRB- cord-010092-uftc8inx 11213 12 involved involve VBD cord-010092-uftc8inx 11213 13 an an DT cord-010092-uftc8inx 11213 14 eventual eventual JJ cord-010092-uftc8inx 11213 15 switch switch NN cord-010092-uftc8inx 11213 16 to to IN cord-010092-uftc8inx 11213 17 group group NN cord-010092-uftc8inx 11213 18 - - HYPH cord-010092-uftc8inx 11213 19 specific specific JJ cord-010092-uftc8inx 11213 20 RBCs rbc NNS cord-010092-uftc8inx 11213 21 ( ( -LRB- cord-010092-uftc8inx 11213 22 range range NN cord-010092-uftc8inx 11213 23 of of IN cord-010092-uftc8inx 11213 24 emergency emergency NN cord-010092-uftc8inx 11213 25 units unit NNS cord-010092-uftc8inx 11213 26 , , , cord-010092-uftc8inx 11213 27 1 1 CD cord-010092-uftc8inx 11213 28 - - SYM cord-010092-uftc8inx 11213 29 13 13 CD cord-010092-uftc8inx 11213 30 units unit NNS cord-010092-uftc8inx 11213 31 ) ) -RRB- cord-010092-uftc8inx 11213 32 . . . cord-010092-uftc8inx 11214 1 The the DT cord-010092-uftc8inx 11214 2 main main JJ cord-010092-uftc8inx 11214 3 requester requester NN cord-010092-uftc8inx 11214 4 was be VBD cord-010092-uftc8inx 11214 5 the the DT cord-010092-uftc8inx 11214 6 emergency emergency NN cord-010092-uftc8inx 11214 7 department department NN cord-010092-uftc8inx 11214 8 ( ( -LRB- cord-010092-uftc8inx 11214 9 53 53 CD cord-010092-uftc8inx 11214 10 % % NN cord-010092-uftc8inx 11214 11 ) ) -RRB- cord-010092-uftc8inx 11214 12 . . . cord-010092-uftc8inx 11215 1 The the DT cord-010092-uftc8inx 11215 2 most most RBS cord-010092-uftc8inx 11215 3 common common JJ cord-010092-uftc8inx 11215 4 clinical clinical JJ cord-010092-uftc8inx 11215 5 indication indication NN cord-010092-uftc8inx 11215 6 for for IN cord-010092-uftc8inx 11215 7 transfusion transfusion NN cord-010092-uftc8inx 11215 8 was be VBD cord-010092-uftc8inx 11215 9 acute acute JJ cord-010092-uftc8inx 11215 10 gastrointestinal gastrointestinal JJ cord-010092-uftc8inx 11215 11 bleeding bleeding NN cord-010092-uftc8inx 11215 12 ( ( -LRB- cord-010092-uftc8inx 11215 13 49 49 CD cord-010092-uftc8inx 11215 14 % % NN cord-010092-uftc8inx 11215 15 ) ) -RRB- cord-010092-uftc8inx 11215 16 . . . cord-010092-uftc8inx 11216 1 Of of IN cord-010092-uftc8inx 11216 2 the the DT cord-010092-uftc8inx 11216 3 105 105 CD cord-010092-uftc8inx 11216 4 episodes episode NNS cord-010092-uftc8inx 11216 5 , , , cord-010092-uftc8inx 11216 6 28 28 CD cord-010092-uftc8inx 11216 7 episodes episode NNS cord-010092-uftc8inx 11216 8 ( ( -LRB- cord-010092-uftc8inx 11216 9 27 27 CD cord-010092-uftc8inx 11216 10 % % NN cord-010092-uftc8inx 11216 11 ) ) -RRB- cord-010092-uftc8inx 11216 12 did do VBD cord-010092-uftc8inx 11216 13 not not RB cord-010092-uftc8inx 11216 14 meet meet VB cord-010092-uftc8inx 11216 15 the the DT cord-010092-uftc8inx 11216 16 guidelines guideline NNS cord-010092-uftc8inx 11216 17 for for IN cord-010092-uftc8inx 11216 18 emergency emergency NN cord-010092-uftc8inx 11216 19 use use NN cord-010092-uftc8inx 11216 20 because because IN cord-010092-uftc8inx 11216 21 > > XX cord-010092-uftc8inx 11216 22 2 2 CD cord-010092-uftc8inx 11216 23 units unit NNS cord-010092-uftc8inx 11216 24 of of IN cord-010092-uftc8inx 11216 25 emergency emergency NN cord-010092-uftc8inx 11217 1 uncrossmatched uncrossmatched JJ cord-010092-uftc8inx 11218 1 O o UH cord-010092-uftc8inx 11218 2 RhD RhD NNP cord-010092-uftc8inx 11219 1 -neg -neg : cord-010092-uftc8inx 11219 2 RBCs rbc NNS cord-010092-uftc8inx 11219 3 were be VBD cord-010092-uftc8inx 11219 4 issued issue VBN cord-010092-uftc8inx 11219 5 . . . cord-010092-uftc8inx 11220 1 2 2 CD cord-010092-uftc8inx 11220 2 episodes episode NNS cord-010092-uftc8inx 11220 3 ( ( -LRB- cord-010092-uftc8inx 11220 4 2 2 CD cord-010092-uftc8inx 11220 5 % % NN cord-010092-uftc8inx 11220 6 ) ) -RRB- cord-010092-uftc8inx 11220 7 were be VBD cord-010092-uftc8inx 11220 8 flagged flag VBN cord-010092-uftc8inx 11220 9 as as IN cord-010092-uftc8inx 11220 10 potentially potentially RB cord-010092-uftc8inx 11220 11 inappropriate inappropriate JJ cord-010092-uftc8inx 11220 12 as as IN cord-010092-uftc8inx 11220 13 the the DT cord-010092-uftc8inx 11220 14 patients patient NNS cord-010092-uftc8inx 11220 15 were be VBD cord-010092-uftc8inx 11220 16 clinically clinically RB cord-010092-uftc8inx 11220 17 stable stable JJ cord-010092-uftc8inx 11220 18 according accord VBG cord-010092-uftc8inx 11220 19 to to IN cord-010092-uftc8inx 11220 20 documentation documentation NN cord-010092-uftc8inx 11220 21 in in IN cord-010092-uftc8inx 11220 22 the the DT cord-010092-uftc8inx 11220 23 medical medical JJ cord-010092-uftc8inx 11220 24 records record NNS cord-010092-uftc8inx 11220 25 . . . cord-010092-uftc8inx 11221 1 30 30 CD cord-010092-uftc8inx 11221 2 episodes episode NNS cord-010092-uftc8inx 11221 3 ( ( -LRB- cord-010092-uftc8inx 11221 4 29 29 CD cord-010092-uftc8inx 11221 5 % % NN cord-010092-uftc8inx 11221 6 ) ) -RRB- cord-010092-uftc8inx 11221 7 were be VBD cord-010092-uftc8inx 11221 8 identified identify VBN cord-010092-uftc8inx 11221 9 as as IN cord-010092-uftc8inx 11221 10 potentially potentially RB cord-010092-uftc8inx 11221 11 preventable preventable JJ cord-010092-uftc8inx 11221 12 due due IN cord-010092-uftc8inx 11221 13 to to TO cord-010092-uftc8inx 11221 14 delay delay VB cord-010092-uftc8inx 11221 15 in in IN cord-010092-uftc8inx 11221 16 pre pre JJ cord-010092-uftc8inx 11221 17 - - JJ cord-010092-uftc8inx 11221 18 transfusion transfusion JJ cord-010092-uftc8inx 11221 19 sample sample NN cord-010092-uftc8inx 11221 20 collection collection NN cord-010092-uftc8inx 11221 21 ( ( -LRB- cord-010092-uftc8inx 11221 22 defined define VBN cord-010092-uftc8inx 11221 23 as as IN cord-010092-uftc8inx 11221 24 > > NN cord-010092-uftc8inx 11221 25 1 1 CD cord-010092-uftc8inx 11221 26 h h NN cord-010092-uftc8inx 11221 27 elapsed elapse VBN cord-010092-uftc8inx 11221 28 between between IN cord-010092-uftc8inx 11221 29 patient patient JJ cord-010092-uftc8inx 11221 30 arrival arrival NN cord-010092-uftc8inx 11221 31 and and CC cord-010092-uftc8inx 11221 32 group group NN cord-010092-uftc8inx 11221 33 and and CC cord-010092-uftc8inx 11221 34 screen screen NN cord-010092-uftc8inx 11221 35 sample sample NN cord-010092-uftc8inx 11221 36 collection collection NN cord-010092-uftc8inx 11221 37 ) ) -RRB- cord-010092-uftc8inx 11221 38 in in IN cord-010092-uftc8inx 11221 39 the the DT cord-010092-uftc8inx 11221 40 setting setting NN cord-010092-uftc8inx 11221 41 of of IN cord-010092-uftc8inx 11221 42 acute acute JJ cord-010092-uftc8inx 11221 43 bleeding bleeding NN cord-010092-uftc8inx 11221 44 ( ( -LRB- cord-010092-uftc8inx 11221 45 6 6 CD cord-010092-uftc8inx 11221 46 % % NN cord-010092-uftc8inx 11221 47 ) ) -RRB- cord-010092-uftc8inx 11221 48 , , , cord-010092-uftc8inx 11221 49 receipt receipt NN cord-010092-uftc8inx 11221 50 of of IN cord-010092-uftc8inx 11221 51 an an DT cord-010092-uftc8inx 11221 52 unsuitable unsuitable JJ cord-010092-uftc8inx 11221 53 pretransfusion pretransfusion NN cord-010092-uftc8inx 11221 54 sample sample NN cord-010092-uftc8inx 11221 55 requiring require VBG cord-010092-uftc8inx 11221 56 sample sample NN cord-010092-uftc8inx 11221 57 recollection recollection NN cord-010092-uftc8inx 11221 58 ( ( -LRB- cord-010092-uftc8inx 11221 59 5 5 CD cord-010092-uftc8inx 11221 60 % % NN cord-010092-uftc8inx 11221 61 ) ) -RRB- cord-010092-uftc8inx 11221 62 , , , cord-010092-uftc8inx 11221 63 delay delay VB cord-010092-uftc8inx 11221 64 in in IN cord-010092-uftc8inx 11221 65 pre pre JJ cord-010092-uftc8inx 11221 66 - - JJ cord-010092-uftc8inx 11221 67 transfusion transfusion JJ cord-010092-uftc8inx 11221 68 sample sample NN cord-010092-uftc8inx 11221 69 processing processing NN cord-010092-uftc8inx 11221 70 ( ( -LRB- cord-010092-uftc8inx 11221 71 4 4 CD cord-010092-uftc8inx 11221 72 % % NN cord-010092-uftc8inx 11221 73 ) ) -RRB- cord-010092-uftc8inx 11221 74 , , , cord-010092-uftc8inx 11221 75 no no DT cord-010092-uftc8inx 11221 76 valid valid JJ cord-010092-uftc8inx 11221 77 pre pre JJ cord-010092-uftc8inx 11221 78 - - JJ cord-010092-uftc8inx 11221 79 transfusion transfusion JJ cord-010092-uftc8inx 11221 80 sample sample NN cord-010092-uftc8inx 11221 81 being be VBG cord-010092-uftc8inx 11221 82 available available JJ cord-010092-uftc8inx 11221 83 at at IN cord-010092-uftc8inx 11221 84 the the DT cord-010092-uftc8inx 11221 85 time time NN cord-010092-uftc8inx 11221 86 of of IN cord-010092-uftc8inx 11221 87 the the DT cord-010092-uftc8inx 11221 88 bleeding bleeding JJ cord-010092-uftc8inx 11221 89 episode episode NN cord-010092-uftc8inx 11221 90 despite despite IN cord-010092-uftc8inx 11221 91 having have VBG cord-010092-uftc8inx 11221 92 a a DT cord-010092-uftc8inx 11221 93 planned plan VBN cord-010092-uftc8inx 11221 94 elective elective JJ cord-010092-uftc8inx 11221 95 procedure procedure NN cord-010092-uftc8inx 11221 96 or or CC cord-010092-uftc8inx 11221 97 being be VBG cord-010092-uftc8inx 11221 98 an an DT cord-010092-uftc8inx 11221 99 inpatient inpatient JJ cord-010092-uftc8inx 11221 100 with with IN cord-010092-uftc8inx 11221 101 recent recent JJ cord-010092-uftc8inx 11221 102 clinical clinical JJ cord-010092-uftc8inx 11221 103 bleeding bleeding NN cord-010092-uftc8inx 11221 104 ( ( -LRB- cord-010092-uftc8inx 11221 105 10 10 CD cord-010092-uftc8inx 11221 106 % % NN cord-010092-uftc8inx 11221 107 ) ) -RRB- cord-010092-uftc8inx 11221 108 . . . cord-010092-uftc8inx 11222 1 Only only RB cord-010092-uftc8inx 11222 2 one one CD cord-010092-uftc8inx 11222 3 patient patient NN cord-010092-uftc8inx 11222 4 was be VBD cord-010092-uftc8inx 11222 5 investigated investigate VBN cord-010092-uftc8inx 11222 6 for for IN cord-010092-uftc8inx 11222 7 potential potential JJ cord-010092-uftc8inx 11222 8 transfusion transfusion NN cord-010092-uftc8inx 11222 9 - - HYPH cord-010092-uftc8inx 11222 10 related relate VBN cord-010092-uftc8inx 11222 11 adverse adverse JJ cord-010092-uftc8inx 11222 12 outcome outcome NN cord-010092-uftc8inx 11222 13 ( ( -LRB- cord-010092-uftc8inx 11222 14 1 1 CD cord-010092-uftc8inx 11222 15 % % NN cord-010092-uftc8inx 11222 16 ) ) -RRB- cord-010092-uftc8inx 11222 17 which which WDT cord-010092-uftc8inx 11222 18 was be VBD cord-010092-uftc8inx 11222 19 thought think VBN cord-010092-uftc8inx 11222 20 likely likely RB cord-010092-uftc8inx 11222 21 due due IN cord-010092-uftc8inx 11222 22 to to IN cord-010092-uftc8inx 11222 23 concurrent concurrent JJ cord-010092-uftc8inx 11222 24 sepsis sepsis NN cord-010092-uftc8inx 11222 25 . . . cord-010092-uftc8inx 11223 1 Summary Summary NNP cord-010092-uftc8inx 11223 2 / / SYM cord-010092-uftc8inx 11223 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 11223 4 : : : cord-010092-uftc8inx 11224 1 Over over IN cord-010092-uftc8inx 11224 2 six six CD cord-010092-uftc8inx 11224 3 years year NNS cord-010092-uftc8inx 11224 4 , , , cord-010092-uftc8inx 11224 5 105 105 CD cord-010092-uftc8inx 11224 6 episodes episode NNS cord-010092-uftc8inx 11224 7 utilising utilise VBG cord-010092-uftc8inx 11224 8 emergency emergency NN cord-010092-uftc8inx 11225 1 uncrossmatched uncrossmatched JJ cord-010092-uftc8inx 11226 1 O o UH cord-010092-uftc8inx 11226 2 RhD RhD NNP cord-010092-uftc8inx 11227 1 -neg -neg : cord-010092-uftc8inx 11227 2 RBCs rbc NNS cord-010092-uftc8inx 11227 3 were be VBD cord-010092-uftc8inx 11227 4 identified identify VBN cord-010092-uftc8inx 11227 5 with with IN cord-010092-uftc8inx 11227 6 241 241 CD cord-010092-uftc8inx 11227 7 RBCs rbc NNS cord-010092-uftc8inx 11227 8 issued issue VBN cord-010092-uftc8inx 11227 9 and and CC cord-010092-uftc8inx 11227 10 2 2 CD cord-010092-uftc8inx 11227 11 RBCs rbc NNS cord-010092-uftc8inx 11227 12 discarded discard VBN cord-010092-uftc8inx 11227 13 . . . cord-010092-uftc8inx 11228 1 A a DT cord-010092-uftc8inx 11228 2 significant significant JJ cord-010092-uftc8inx 11228 3 proportion proportion NN cord-010092-uftc8inx 11228 4 of of IN cord-010092-uftc8inx 11228 5 episodes episode NNS cord-010092-uftc8inx 11228 6 ( ( -LRB- cord-010092-uftc8inx 11228 7 29 29 CD cord-010092-uftc8inx 11228 8 % % NN cord-010092-uftc8inx 11228 9 ) ) -RRB- cord-010092-uftc8inx 11228 10 were be VBD cord-010092-uftc8inx 11228 11 potentially potentially RB cord-010092-uftc8inx 11228 12 avoidable avoidable JJ cord-010092-uftc8inx 11228 13 if if IN cord-010092-uftc8inx 11228 14 there there EX cord-010092-uftc8inx 11228 15 had have VBD cord-010092-uftc8inx 11228 16 been be VBN cord-010092-uftc8inx 11228 17 a a DT cord-010092-uftc8inx 11228 18 valid valid JJ cord-010092-uftc8inx 11228 19 pre pre JJ cord-010092-uftc8inx 11228 20 - - JJ cord-010092-uftc8inx 11228 21 transfusion transfusion JJ cord-010092-uftc8inx 11228 22 sample sample NN cord-010092-uftc8inx 11228 23 available available JJ cord-010092-uftc8inx 11228 24 in in IN cord-010092-uftc8inx 11228 25 the the DT cord-010092-uftc8inx 11228 26 transfusion transfusion NN cord-010092-uftc8inx 11228 27 laboratory laboratory NN cord-010092-uftc8inx 11228 28 at at IN cord-010092-uftc8inx 11228 29 the the DT cord-010092-uftc8inx 11228 30 time time NN cord-010092-uftc8inx 11228 31 of of IN cord-010092-uftc8inx 11228 32 the the DT cord-010092-uftc8inx 11228 33 episode episode NN cord-010092-uftc8inx 11228 34 . . . cord-010092-uftc8inx 11229 1 Efforts effort NNS cord-010092-uftc8inx 11229 2 to to TO cord-010092-uftc8inx 11229 3 minimise minimise VB cord-010092-uftc8inx 11229 4 use use NN cord-010092-uftc8inx 11229 5 of of IN cord-010092-uftc8inx 11229 6 this this DT cord-010092-uftc8inx 11229 7 precious precious JJ cord-010092-uftc8inx 11229 8 resource resource NN cord-010092-uftc8inx 11229 9 are be VBP cord-010092-uftc8inx 11229 10 ongoing ongoing JJ cord-010092-uftc8inx 11229 11 , , , cord-010092-uftc8inx 11229 12 and and CC cord-010092-uftc8inx 11229 13 include include VBP cord-010092-uftc8inx 11229 14 feedback feedback NN cord-010092-uftc8inx 11229 15 to to IN cord-010092-uftc8inx 11229 16 clinical clinical JJ cord-010092-uftc8inx 11229 17 units unit NNS cord-010092-uftc8inx 11229 18 regarding regard VBG cord-010092-uftc8inx 11229 19 importance importance NN cord-010092-uftc8inx 11229 20 of of IN cord-010092-uftc8inx 11229 21 valid valid JJ cord-010092-uftc8inx 11229 22 pretransfusion pretransfusion NN cord-010092-uftc8inx 11229 23 samples sample NNS cord-010092-uftc8inx 11229 24 prior prior RB cord-010092-uftc8inx 11229 25 to to IN cord-010092-uftc8inx 11229 26 applicable applicable JJ cord-010092-uftc8inx 11229 27 invasive invasive JJ cord-010092-uftc8inx 11229 28 procedures procedure NNS cord-010092-uftc8inx 11229 29 and and CC cord-010092-uftc8inx 11229 30 in in IN cord-010092-uftc8inx 11229 31 bleeding bleed VBG cord-010092-uftc8inx 11229 32 patients patient NNS cord-010092-uftc8inx 11229 33 , , , cord-010092-uftc8inx 11229 34 ongoing ongoing JJ cord-010092-uftc8inx 11229 35 education education NN cord-010092-uftc8inx 11229 36 to to IN cord-010092-uftc8inx 11229 37 medical medical JJ cord-010092-uftc8inx 11229 38 and and CC cord-010092-uftc8inx 11229 39 nursing nursing NN cord-010092-uftc8inx 11229 40 staff staff NN cord-010092-uftc8inx 11229 41 , , , cord-010092-uftc8inx 11229 42 and and CC cord-010092-uftc8inx 11229 43 continuing continue VBG cord-010092-uftc8inx 11229 44 audit audit NN cord-010092-uftc8inx 11229 45 of of IN cord-010092-uftc8inx 11229 46 use use NN cord-010092-uftc8inx 11229 47 of of IN cord-010092-uftc8inx 11229 48 this this DT cord-010092-uftc8inx 11229 49 blood blood NN cord-010092-uftc8inx 11229 50 component component NN cord-010092-uftc8inx 11229 51 in in IN cord-010092-uftc8inx 11229 52 the the DT cord-010092-uftc8inx 11229 53 hospital hospital NN cord-010092-uftc8inx 11229 54 haemovigilance haemovigilance NNP cord-010092-uftc8inx 11229 55 programme programme NN cord-010092-uftc8inx 11229 56 . . . cord-010092-uftc8inx 11230 1 Abstract Abstract NNP cord-010092-uftc8inx 11230 2 withdrawn withdraw VBN cord-010092-uftc8inx 11230 3 . . . cord-010092-uftc8inx 11231 1 Abstract Abstract NNP cord-010092-uftc8inx 11231 2 withdrawn withdraw VBN cord-010092-uftc8inx 11231 3 . . . cord-010092-uftc8inx 11232 1 Background background NN cord-010092-uftc8inx 11232 2 : : : cord-010092-uftc8inx 11233 1 Platelet platelet NN cord-010092-uftc8inx 11233 2 transfusions transfusion NNS cord-010092-uftc8inx 11233 3 are be VBP cord-010092-uftc8inx 11233 4 often often RB cord-010092-uftc8inx 11233 5 given give VBN cord-010092-uftc8inx 11233 6 prophylactically prophylactically RB cord-010092-uftc8inx 11233 7 to to IN cord-010092-uftc8inx 11233 8 thrombocytopenic thrombocytopenic JJ cord-010092-uftc8inx 11233 9 hematology hematology NN cord-010092-uftc8inx 11233 10 patients patient NNS cord-010092-uftc8inx 11233 11 . . . cord-010092-uftc8inx 11234 1 To to TO cord-010092-uftc8inx 11234 2 which which WDT cord-010092-uftc8inx 11234 3 extent extent NN cord-010092-uftc8inx 11234 4 platelet platelet NN cord-010092-uftc8inx 11234 5 function function NN cord-010092-uftc8inx 11234 6 improves improve VBZ cord-010092-uftc8inx 11234 7 after after IN cord-010092-uftc8inx 11234 8 transfusion transfusion NN cord-010092-uftc8inx 11234 9 , , , cord-010092-uftc8inx 11234 10 and and CC cord-010092-uftc8inx 11234 11 how how WRB cord-010092-uftc8inx 11234 12 this this DT cord-010092-uftc8inx 11234 13 improvement improvement NN cord-010092-uftc8inx 11234 14 correlates correlate VBZ cord-010092-uftc8inx 11234 15 with with IN cord-010092-uftc8inx 11234 16 an an DT cord-010092-uftc8inx 11234 17 increase increase NN cord-010092-uftc8inx 11234 18 in in IN cord-010092-uftc8inx 11234 19 platelet platelet NN cord-010092-uftc8inx 11234 20 count count NN cord-010092-uftc8inx 11234 21 , , , cord-010092-uftc8inx 11234 22 is be VBZ cord-010092-uftc8inx 11234 23 not not RB cord-010092-uftc8inx 11234 24 well well RB cord-010092-uftc8inx 11234 25 studied study VBN cord-010092-uftc8inx 11234 26 . . . cord-010092-uftc8inx 11235 1 Flow flow NN cord-010092-uftc8inx 11235 2 cytometry cytometry NN cord-010092-uftc8inx 11235 3 has have VBZ cord-010092-uftc8inx 11235 4 been be VBN cord-010092-uftc8inx 11235 5 used use VBN cord-010092-uftc8inx 11235 6 to to TO cord-010092-uftc8inx 11235 7 evaluate evaluate VB cord-010092-uftc8inx 11235 8 platelet platelet NN cord-010092-uftc8inx 11235 9 function function NN cord-010092-uftc8inx 11235 10 after after IN cord-010092-uftc8inx 11235 11 transfusion transfusion NN cord-010092-uftc8inx 11235 12 in in IN cord-010092-uftc8inx 11235 13 a a DT cord-010092-uftc8inx 11235 14 few few JJ cord-010092-uftc8inx 11235 15 studies study NNS cord-010092-uftc8inx 11235 16 and and CC cord-010092-uftc8inx 11235 17 can can MD cord-010092-uftc8inx 11235 18 be be VB cord-010092-uftc8inx 11235 19 performed perform VBN cord-010092-uftc8inx 11235 20 even even RB cord-010092-uftc8inx 11235 21 at at IN cord-010092-uftc8inx 11235 22 low low JJ cord-010092-uftc8inx 11235 23 platelet platelet NN cord-010092-uftc8inx 11235 24 counts count NNS cord-010092-uftc8inx 11235 25 . . . cord-010092-uftc8inx 11236 1 Rotational rotational JJ cord-010092-uftc8inx 11236 2 thromboelastometry thromboelastometry NN cord-010092-uftc8inx 11236 3 ( ( -LRB- cord-010092-uftc8inx 11236 4 ROTEM ROTEM NNP cord-010092-uftc8inx 11236 5 ) ) -RRB- cord-010092-uftc8inx 11236 6 represents represent VBZ cord-010092-uftc8inx 11236 7 a a DT cord-010092-uftc8inx 11236 8 more more RBR cord-010092-uftc8inx 11236 9 physiological physiological JJ cord-010092-uftc8inx 11236 10 measure measure NN cord-010092-uftc8inx 11236 11 of of IN cord-010092-uftc8inx 11236 12 platelet platelet NN cord-010092-uftc8inx 11236 13 function function NN cord-010092-uftc8inx 11236 14 in in IN cord-010092-uftc8inx 11236 15 whole whole JJ cord-010092-uftc8inx 11236 16 blood blood NN cord-010092-uftc8inx 11236 17 that that WDT cord-010092-uftc8inx 11236 18 has have VBZ cord-010092-uftc8inx 11236 19 not not RB cord-010092-uftc8inx 11236 20 been be VBN cord-010092-uftc8inx 11236 21 extensively extensively RB cord-010092-uftc8inx 11236 22 used use VBN cord-010092-uftc8inx 11236 23 in in IN cord-010092-uftc8inx 11236 24 transfusion transfusion NN cord-010092-uftc8inx 11236 25 settings setting NNS cord-010092-uftc8inx 11236 26 . . . cord-010092-uftc8inx 11237 1 We -PRON- PRP cord-010092-uftc8inx 11237 2 used use VBD cord-010092-uftc8inx 11237 3 these these DT cord-010092-uftc8inx 11237 4 methods method NNS cord-010092-uftc8inx 11237 5 to to TO cord-010092-uftc8inx 11237 6 investigate investigate VB cord-010092-uftc8inx 11237 7 if if IN cord-010092-uftc8inx 11237 8 platelet platelet NN cord-010092-uftc8inx 11237 9 transfusion transfusion NN cord-010092-uftc8inx 11237 10 improves improve VBZ cord-010092-uftc8inx 11237 11 platelet platelet NN cord-010092-uftc8inx 11237 12 function function NN cord-010092-uftc8inx 11237 13 in in IN cord-010092-uftc8inx 11237 14 hematology hematology NN cord-010092-uftc8inx 11237 15 patients patient NNS cord-010092-uftc8inx 11237 16 and and CC cord-010092-uftc8inx 11237 17 if if IN cord-010092-uftc8inx 11237 18 improvement improvement NN cord-010092-uftc8inx 11237 19 correlates correlate VBZ cord-010092-uftc8inx 11237 20 with with IN cord-010092-uftc8inx 11237 21 increased increase VBN cord-010092-uftc8inx 11237 22 platelet platelet NN cord-010092-uftc8inx 11237 23 counts count NNS cord-010092-uftc8inx 11237 24 . . . cord-010092-uftc8inx 11238 1 Aims aim VBZ cord-010092-uftc8inx 11238 2 : : : cord-010092-uftc8inx 11239 1 The the DT cord-010092-uftc8inx 11239 2 aim aim NN cord-010092-uftc8inx 11239 3 was be VBD cord-010092-uftc8inx 11239 4 to to TO cord-010092-uftc8inx 11239 5 evaluate evaluate VB cord-010092-uftc8inx 11239 6 the the DT cord-010092-uftc8inx 11239 7 relationship relationship NN cord-010092-uftc8inx 11239 8 between between IN cord-010092-uftc8inx 11239 9 response response NN cord-010092-uftc8inx 11239 10 to to IN cord-010092-uftc8inx 11239 11 platelet platelet NN cord-010092-uftc8inx 11239 12 transfusion transfusion NN cord-010092-uftc8inx 11239 13 , , , cord-010092-uftc8inx 11239 14 measured measure VBN cord-010092-uftc8inx 11239 15 as as IN cord-010092-uftc8inx 11239 16 corrected correct VBN cord-010092-uftc8inx 11239 17 count count NN cord-010092-uftc8inx 11239 18 increments increment NNS cord-010092-uftc8inx 11239 19 ( ( -LRB- cord-010092-uftc8inx 11239 20 CCI CCI NNP cord-010092-uftc8inx 11239 21 ) ) -RRB- cord-010092-uftc8inx 11239 22 , , , cord-010092-uftc8inx 11239 23 and and CC cord-010092-uftc8inx 11239 24 platelet platelet NN cord-010092-uftc8inx 11239 25 function function NN cord-010092-uftc8inx 11239 26 in in IN cord-010092-uftc8inx 11239 27 thrombocytopenic thrombocytopenic JJ cord-010092-uftc8inx 11239 28 patients patient NNS cord-010092-uftc8inx 11239 29 with with IN cord-010092-uftc8inx 11239 30 hematological hematological JJ cord-010092-uftc8inx 11239 31 disorders disorder NNS cord-010092-uftc8inx 11239 32 . . . cord-010092-uftc8inx 11240 1 Methods method NNS cord-010092-uftc8inx 11240 2 : : : cord-010092-uftc8inx 11240 3 Blood blood NN cord-010092-uftc8inx 11240 4 samples sample NNS cord-010092-uftc8inx 11240 5 ( ( -LRB- cord-010092-uftc8inx 11240 6 sodium sodium NN cord-010092-uftc8inx 11240 7 - - HYPH cord-010092-uftc8inx 11240 8 citrate citrate NN cord-010092-uftc8inx 11240 9 anticoagulated anticoagulated NNP cord-010092-uftc8inx 11240 10 ) ) -RRB- cord-010092-uftc8inx 11240 11 were be VBD cord-010092-uftc8inx 11240 12 collected collect VBN cord-010092-uftc8inx 11240 13 from from IN cord-010092-uftc8inx 11240 14 unselected unselected JJ cord-010092-uftc8inx 11240 15 hematology hematology NN cord-010092-uftc8inx 11240 16 patients patient NNS cord-010092-uftc8inx 11240 17 receiving receive VBG cord-010092-uftc8inx 11240 18 prophylactic prophylactic JJ cord-010092-uftc8inx 11240 19 platelet platelet NN cord-010092-uftc8inx 11240 20 transfusions transfusion NNS cord-010092-uftc8inx 11240 21 , , , cord-010092-uftc8inx 11240 22 after after IN cord-010092-uftc8inx 11240 23 informed informed JJ cord-010092-uftc8inx 11240 24 consent consent NN cord-010092-uftc8inx 11240 25 had have VBD cord-010092-uftc8inx 11240 26 been be VBN cord-010092-uftc8inx 11240 27 obtained obtain VBN cord-010092-uftc8inx 11240 28 . . . cord-010092-uftc8inx 11241 1 Samples sample NNS cord-010092-uftc8inx 11241 2 were be VBD cord-010092-uftc8inx 11241 3 taken take VBN cord-010092-uftc8inx 11241 4 at at IN cord-010092-uftc8inx 11241 5 three three CD cord-010092-uftc8inx 11241 6 time time NN cord-010092-uftc8inx 11241 7 - - HYPH cord-010092-uftc8inx 11241 8 points point NNS cord-010092-uftc8inx 11241 9 : : : cord-010092-uftc8inx 11241 10 within within IN cord-010092-uftc8inx 11241 11 1 1 CD cord-010092-uftc8inx 11241 12 h h NN cord-010092-uftc8inx 11241 13 before before IN cord-010092-uftc8inx 11241 14 transfusion transfusion NN cord-010092-uftc8inx 11241 15 , , , cord-010092-uftc8inx 11241 16 1 1 CD cord-010092-uftc8inx 11241 17 h h NN cord-010092-uftc8inx 11241 18 after after IN cord-010092-uftc8inx 11241 19 and and CC cord-010092-uftc8inx 11241 20 14 14 CD cord-010092-uftc8inx 11241 21 - - SYM cord-010092-uftc8inx 11241 22 24 24 CD cord-010092-uftc8inx 11241 23 h h NN cord-010092-uftc8inx 11241 24 after after IN cord-010092-uftc8inx 11241 25 transfusion transfusion NN cord-010092-uftc8inx 11241 26 ( ( -LRB- cord-010092-uftc8inx 11241 27 via via IN cord-010092-uftc8inx 11241 28 a a DT cord-010092-uftc8inx 11241 29 central central JJ cord-010092-uftc8inx 11241 30 venous venous JJ cord-010092-uftc8inx 11241 31 catheter catheter NN cord-010092-uftc8inx 11241 32 or or CC cord-010092-uftc8inx 11241 33 a a DT cord-010092-uftc8inx 11241 34 subcutaneous subcutaneous JJ cord-010092-uftc8inx 11241 35 venous venous JJ cord-010092-uftc8inx 11241 36 port port NN cord-010092-uftc8inx 11241 37 ) ) -RRB- cord-010092-uftc8inx 11241 38 . . . cord-010092-uftc8inx 11242 1 For for IN cord-010092-uftc8inx 11242 2 each each DT cord-010092-uftc8inx 11242 3 time time NN cord-010092-uftc8inx 11242 4 - - HYPH cord-010092-uftc8inx 11242 5 point point NN cord-010092-uftc8inx 11242 6 , , , cord-010092-uftc8inx 11242 7 platelet platelet NN cord-010092-uftc8inx 11242 8 response response NN cord-010092-uftc8inx 11242 9 to to IN cord-010092-uftc8inx 11242 10 adenosine adenosine NN cord-010092-uftc8inx 11242 11 diphosphate diphosphate NN cord-010092-uftc8inx 11242 12 ( ( -LRB- cord-010092-uftc8inx 11242 13 ADP ADP NNP cord-010092-uftc8inx 11242 14 ) ) -RRB- cord-010092-uftc8inx 11242 15 and and CC cord-010092-uftc8inx 11242 16 thrombin thrombin JJ cord-010092-uftc8inx 11242 17 receptor receptor NN cord-010092-uftc8inx 11242 18 - - HYPH cord-010092-uftc8inx 11242 19 activating activate VBG cord-010092-uftc8inx 11242 20 peptide peptide NN cord-010092-uftc8inx 11242 21 ( ( -LRB- cord-010092-uftc8inx 11242 22 TRAP-6 TRAP-6 NNP cord-010092-uftc8inx 11242 23 ) ) -RRB- cord-010092-uftc8inx 11242 24 was be VBD cord-010092-uftc8inx 11242 25 assessed assess VBN cord-010092-uftc8inx 11242 26 by by IN cord-010092-uftc8inx 11242 27 flow flow NN cord-010092-uftc8inx 11242 28 cytometry cytometry NN cord-010092-uftc8inx 11242 29 by by IN cord-010092-uftc8inx 11242 30 measuring measure VBG cord-010092-uftc8inx 11242 31 P p NN cord-010092-uftc8inx 11242 32 - - HYPH cord-010092-uftc8inx 11242 33 selectin selectin NNP cord-010092-uftc8inx 11242 34 and and CC cord-010092-uftc8inx 11242 35 PAC-1 pac-1 VB cord-010092-uftc8inx 11242 36 expression expression NN cord-010092-uftc8inx 11242 37 on on IN cord-010092-uftc8inx 11242 38 single single JJ cord-010092-uftc8inx 11242 39 platelets platelet NNS cord-010092-uftc8inx 11242 40 . . . cord-010092-uftc8inx 11243 1 ROTEM ROTEM NNP cord-010092-uftc8inx 11243 2 analysis analysis NN cord-010092-uftc8inx 11243 3 was be VBD cord-010092-uftc8inx 11243 4 also also RB cord-010092-uftc8inx 11243 5 performed perform VBN cord-010092-uftc8inx 11243 6 on on IN cord-010092-uftc8inx 11243 7 all all DT cord-010092-uftc8inx 11243 8 samples sample NNS cord-010092-uftc8inx 11243 9 , , , cord-010092-uftc8inx 11243 10 using use VBG cord-010092-uftc8inx 11243 11 INTEM INTEM NNP cord-010092-uftc8inx 11243 12 and and CC cord-010092-uftc8inx 11243 13 EXTEM EXTEM NNP cord-010092-uftc8inx 11243 14 reagents reagent NNS cord-010092-uftc8inx 11243 15 . . . cord-010092-uftc8inx 11244 1 Results result NNS cord-010092-uftc8inx 11244 2 : : : cord-010092-uftc8inx 11245 1 An an DT cord-010092-uftc8inx 11245 2 interim interim JJ cord-010092-uftc8inx 11245 3 analysis analysis NN cord-010092-uftc8inx 11245 4 was be VBD cord-010092-uftc8inx 11245 5 performed perform VBN cord-010092-uftc8inx 11245 6 after after IN cord-010092-uftc8inx 11245 7 inclusion inclusion NN cord-010092-uftc8inx 11245 8 of of IN cord-010092-uftc8inx 11245 9 22 22 CD cord-010092-uftc8inx 11245 10 patients patient NNS cord-010092-uftc8inx 11245 11 . . . cord-010092-uftc8inx 11246 1 The the DT cord-010092-uftc8inx 11246 2 mean mean JJ cord-010092-uftc8inx 11246 3 platelet platelet NN cord-010092-uftc8inx 11246 4 count count NN cord-010092-uftc8inx 11246 5 before before IN cord-010092-uftc8inx 11246 6 transfusion transfusion NN cord-010092-uftc8inx 11246 7 was be VBD cord-010092-uftc8inx 11246 8 8 8 CD cord-010092-uftc8inx 11246 9 9 9 CD cord-010092-uftc8inx 11246 10 10 10 CD cord-010092-uftc8inx 11246 11 9 9 CD cord-010092-uftc8inx 11246 12 /L /L . cord-010092-uftc8inx 11246 13 ( ( -LRB- cord-010092-uftc8inx 11246 14 range range NNP cord-010092-uftc8inx 11246 15 2 2 CD cord-010092-uftc8inx 11246 16 - - SYM cord-010092-uftc8inx 11246 17 34 34 CD cord-010092-uftc8inx 11246 18 9 9 CD cord-010092-uftc8inx 11246 19 10 10 CD cord-010092-uftc8inx 11246 20 9 9 CD cord-010092-uftc8inx 11246 21 /L /l CD cord-010092-uftc8inx 11246 22 ) ) -RRB- cord-010092-uftc8inx 11246 23 . . . cord-010092-uftc8inx 11247 1 1 1 LS cord-010092-uftc8inx 11248 1 h h NNP cord-010092-uftc8inx 11248 2 CCI CCI NNP cord-010092-uftc8inx 11248 3 was be VBD cord-010092-uftc8inx 11248 4 11 11 CD cord-010092-uftc8inx 11248 5 9 9 CD cord-010092-uftc8inx 11248 6 10 10 CD cord-010092-uftc8inx 11248 7 9 9 CD cord-010092-uftc8inx 11248 8 /L /L . cord-010092-uftc8inx 11248 9 and and CC cord-010092-uftc8inx 11249 1 14 14 CD cord-010092-uftc8inx 11249 2 - - SYM cord-010092-uftc8inx 11249 3 24 24 CD cord-010092-uftc8inx 11249 4 h h NNP cord-010092-uftc8inx 11249 5 CCI CCI NNP cord-010092-uftc8inx 11249 6 was be VBD cord-010092-uftc8inx 11249 7 6 6 CD cord-010092-uftc8inx 11249 8 9 9 CD cord-010092-uftc8inx 11249 9 10 10 CD cord-010092-uftc8inx 11249 10 9 9 CD cord-010092-uftc8inx 11249 11 /L /l CD cord-010092-uftc8inx 11249 12 , , , cord-010092-uftc8inx 11249 13 but but CC cord-010092-uftc8inx 11249 14 response response NN cord-010092-uftc8inx 11249 15 was be VBD cord-010092-uftc8inx 11249 16 highly highly RB cord-010092-uftc8inx 11249 17 variable variable JJ cord-010092-uftc8inx 11249 18 . . . cord-010092-uftc8inx 11250 1 Pselectin pselectin JJ cord-010092-uftc8inx 11250 2 expression expression NN cord-010092-uftc8inx 11250 3 after after IN cord-010092-uftc8inx 11250 4 stimulation stimulation NN cord-010092-uftc8inx 11250 5 with with IN cord-010092-uftc8inx 11250 6 ADP ADP NNP cord-010092-uftc8inx 11250 7 and and CC cord-010092-uftc8inx 11250 8 TRAP trap NN cord-010092-uftc8inx 11250 9 was be VBD cord-010092-uftc8inx 11250 10 significantly significantly RB cord-010092-uftc8inx 11250 11 higher high JJR cord-010092-uftc8inx 11250 12 at at IN cord-010092-uftc8inx 11250 13 1 1 CD cord-010092-uftc8inx 11250 14 h h NN cord-010092-uftc8inx 11250 15 after after IN cord-010092-uftc8inx 11250 16 and and CC cord-010092-uftc8inx 11250 17 14 14 CD cord-010092-uftc8inx 11250 18 - - SYM cord-010092-uftc8inx 11250 19 24 24 CD cord-010092-uftc8inx 11250 20 h h NN cord-010092-uftc8inx 11250 21 after after IN cord-010092-uftc8inx 11250 22 transfusion transfusion NN cord-010092-uftc8inx 11250 23 compared compare VBN cord-010092-uftc8inx 11250 24 to to IN cord-010092-uftc8inx 11250 25 before before IN cord-010092-uftc8inx 11250 26 transfusion transfusion NN cord-010092-uftc8inx 11250 27 ( ( -LRB- cord-010092-uftc8inx 11250 28 P p NN cord-010092-uftc8inx 11250 29 < < XX cord-010092-uftc8inx 11250 30 0.05 0.05 CD cord-010092-uftc8inx 11250 31 ) ) -RRB- cord-010092-uftc8inx 11250 32 . . . cord-010092-uftc8inx 11251 1 PAC-1 pac-1 VB cord-010092-uftc8inx 11251 2 expression expression NN cord-010092-uftc8inx 11251 3 after after IN cord-010092-uftc8inx 11251 4 stimulation stimulation NN cord-010092-uftc8inx 11251 5 with with IN cord-010092-uftc8inx 11251 6 ADP ADP NNP cord-010092-uftc8inx 11251 7 was be VBD cord-010092-uftc8inx 11251 8 significantly significantly RB cord-010092-uftc8inx 11251 9 higher high JJR cord-010092-uftc8inx 11251 10 at at IN cord-010092-uftc8inx 11251 11 14 14 CD cord-010092-uftc8inx 11251 12 - - SYM cord-010092-uftc8inx 11251 13 24 24 CD cord-010092-uftc8inx 11251 14 h h NN cord-010092-uftc8inx 11251 15 after after IN cord-010092-uftc8inx 11251 16 transfusion transfusion NN cord-010092-uftc8inx 11251 17 ( ( -LRB- cord-010092-uftc8inx 11251 18 P p NN cord-010092-uftc8inx 11251 19 < < XX cord-010092-uftc8inx 11251 20 0.001 0.001 CD cord-010092-uftc8inx 11251 21 ) ) -RRB- cord-010092-uftc8inx 11251 22 , , , cord-010092-uftc8inx 11251 23 but but CC cord-010092-uftc8inx 11251 24 not not RB cord-010092-uftc8inx 11251 25 at at IN cord-010092-uftc8inx 11251 26 1 1 CD cord-010092-uftc8inx 11251 27 h h NN cord-010092-uftc8inx 11251 28 after after IN cord-010092-uftc8inx 11251 29 transfusion transfusion NN cord-010092-uftc8inx 11251 30 . . . cord-010092-uftc8inx 11252 1 In in IN cord-010092-uftc8inx 11252 2 ROTEM rotem NN cord-010092-uftc8inx 11252 3 , , , cord-010092-uftc8inx 11252 4 clot clot NN cord-010092-uftc8inx 11252 5 amplitude amplitude NN cord-010092-uftc8inx 11252 6 at at IN cord-010092-uftc8inx 11252 7 10 10 CD cord-010092-uftc8inx 11252 8 and and CC cord-010092-uftc8inx 11252 9 20 20 CD cord-010092-uftc8inx 11252 10 min min NN cord-010092-uftc8inx 11252 11 ( ( -LRB- cord-010092-uftc8inx 11252 12 A10 A10 NNP cord-010092-uftc8inx 11252 13 and and CC cord-010092-uftc8inx 11252 14 A20 A20 NNP cord-010092-uftc8inx 11252 15 ) ) -RRB- cord-010092-uftc8inx 11252 16 as as RB cord-010092-uftc8inx 11252 17 well well RB cord-010092-uftc8inx 11252 18 as as IN cord-010092-uftc8inx 11252 19 maximum maximum JJ cord-010092-uftc8inx 11252 20 clot clot NN cord-010092-uftc8inx 11252 21 firmness firmness NN cord-010092-uftc8inx 11252 22 ( ( -LRB- cord-010092-uftc8inx 11252 23 MCF MCF NNP cord-010092-uftc8inx 11252 24 ) ) -RRB- cord-010092-uftc8inx 11252 25 improved improve VBD cord-010092-uftc8inx 11252 26 after after IN cord-010092-uftc8inx 11252 27 transfusion transfusion NN cord-010092-uftc8inx 11252 28 ( ( -LRB- cord-010092-uftc8inx 11252 29 P p NN cord-010092-uftc8inx 11252 30 < < XX cord-010092-uftc8inx 11252 31 0.05 0.05 CD cord-010092-uftc8inx 11252 32 ) ) -RRB- cord-010092-uftc8inx 11252 33 . . . cord-010092-uftc8inx 11253 1 A a DT cord-010092-uftc8inx 11253 2 significant significant JJ cord-010092-uftc8inx 11253 3 correlation correlation NN cord-010092-uftc8inx 11253 4 between between IN cord-010092-uftc8inx 11253 5 absolute absolute JJ cord-010092-uftc8inx 11253 6 platelet platelet NN cord-010092-uftc8inx 11253 7 count count NN cord-010092-uftc8inx 11253 8 and and CC cord-010092-uftc8inx 11253 9 P p NN cord-010092-uftc8inx 11253 10 - - HYPH cord-010092-uftc8inx 11253 11 selectin selectin JJ cord-010092-uftc8inx 11253 12 expression expression NN cord-010092-uftc8inx 11253 13 after after IN cord-010092-uftc8inx 11253 14 TRAP trap NN cord-010092-uftc8inx 11253 15 and and CC cord-010092-uftc8inx 11253 16 ADP ADP NNP cord-010092-uftc8inx 11253 17 stimulation stimulation NN cord-010092-uftc8inx 11253 18 was be VBD cord-010092-uftc8inx 11253 19 found find VBN cord-010092-uftc8inx 11253 20 ( ( -LRB- cord-010092-uftc8inx 11253 21 r r NN cord-010092-uftc8inx 11253 22 s s NN cord-010092-uftc8inx 11254 1 = = SYM cord-010092-uftc8inx 11254 2 0.53 0.53 CD cord-010092-uftc8inx 11254 3 and and CC cord-010092-uftc8inx 11254 4 0.45 0.45 CD cord-010092-uftc8inx 11254 5 respectively respectively RB cord-010092-uftc8inx 11254 6 , , , cord-010092-uftc8inx 11254 7 P p NN cord-010092-uftc8inx 11254 8 < < XX cord-010092-uftc8inx 11254 9 0.001 0.001 CD cord-010092-uftc8inx 11254 10 ) ) -RRB- cord-010092-uftc8inx 11254 11 . . . cord-010092-uftc8inx 11255 1 Absolute absolute JJ cord-010092-uftc8inx 11255 2 platelet platelet NN cord-010092-uftc8inx 11255 3 count count NN cord-010092-uftc8inx 11255 4 was be VBD cord-010092-uftc8inx 11255 5 also also RB cord-010092-uftc8inx 11255 6 significantly significantly RB cord-010092-uftc8inx 11255 7 correlated correlate VBN cord-010092-uftc8inx 11255 8 with with IN cord-010092-uftc8inx 11255 9 MCF MCF NNP cord-010092-uftc8inx 11255 10 ( ( -LRB- cord-010092-uftc8inx 11255 11 r r NN cord-010092-uftc8inx 11255 12 s s NN cord-010092-uftc8inx 11255 13 = = SYM cord-010092-uftc8inx 11255 14 0.61 0.61 CD cord-010092-uftc8inx 11255 15 , , , cord-010092-uftc8inx 11255 16 P p NN cord-010092-uftc8inx 11255 17 < < XX cord-010092-uftc8inx 11255 18 0.001 0.001 CD cord-010092-uftc8inx 11255 19 ) ) -RRB- cord-010092-uftc8inx 11255 20 , , , cord-010092-uftc8inx 11255 21 where where WRB cord-010092-uftc8inx 11255 22 84 84 CD cord-010092-uftc8inx 11255 23 % % NN cord-010092-uftc8inx 11255 24 of of IN cord-010092-uftc8inx 11255 25 patients patient NNS cord-010092-uftc8inx 11255 26 with with IN cord-010092-uftc8inx 11255 27 a a DT cord-010092-uftc8inx 11255 28 platelet platelet NN cord-010092-uftc8inx 11255 29 count count NN cord-010092-uftc8inx 11255 30 of of IN cord-010092-uftc8inx 11255 31 more more JJR cord-010092-uftc8inx 11255 32 than than IN cord-010092-uftc8inx 11255 33 20 20 CD cord-010092-uftc8inx 11255 34 9 9 CD cord-010092-uftc8inx 11255 35 10 10 CD cord-010092-uftc8inx 11255 36 9 9 CD cord-010092-uftc8inx 11255 37 /L /L . cord-010092-uftc8inx 11255 38 reached reach VBN cord-010092-uftc8inx 11255 39 MCF MCF NNP cord-010092-uftc8inx 11255 40 values value NNS cord-010092-uftc8inx 11255 41 within within IN cord-010092-uftc8inx 11255 42 the the DT cord-010092-uftc8inx 11255 43 reference reference NN cord-010092-uftc8inx 11255 44 interval interval NN cord-010092-uftc8inx 11255 45 . . . cord-010092-uftc8inx 11256 1 Summary Summary NNP cord-010092-uftc8inx 11256 2 / / SYM cord-010092-uftc8inx 11256 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 11256 4 : : : cord-010092-uftc8inx 11257 1 Platelet platelet NN cord-010092-uftc8inx 11257 2 function function NN cord-010092-uftc8inx 11257 3 generally generally RB cord-010092-uftc8inx 11257 4 improves improve VBZ cord-010092-uftc8inx 11257 5 after after IN cord-010092-uftc8inx 11257 6 transfusion transfusion NN cord-010092-uftc8inx 11257 7 and and CC cord-010092-uftc8inx 11257 8 was be VBD cord-010092-uftc8inx 11257 9 in in IN cord-010092-uftc8inx 11257 10 our -PRON- PRP$ cord-010092-uftc8inx 11257 11 patient patient JJ cord-010092-uftc8inx 11257 12 population population NN cord-010092-uftc8inx 11257 13 correlated correlate VBD cord-010092-uftc8inx 11257 14 to to IN cord-010092-uftc8inx 11257 15 the the DT cord-010092-uftc8inx 11257 16 absolute absolute JJ cord-010092-uftc8inx 11257 17 platelet platelet NN cord-010092-uftc8inx 11257 18 count count NN cord-010092-uftc8inx 11257 19 , , , cord-010092-uftc8inx 11257 20 but but CC cord-010092-uftc8inx 11257 21 was be VBD cord-010092-uftc8inx 11257 22 also also RB cord-010092-uftc8inx 11257 23 seen see VBN cord-010092-uftc8inx 11257 24 at at IN cord-010092-uftc8inx 11257 25 the the DT cord-010092-uftc8inx 11257 26 single single JJ cord-010092-uftc8inx 11257 27 platelet platelet NN cord-010092-uftc8inx 11257 28 level level NN cord-010092-uftc8inx 11257 29 in in IN cord-010092-uftc8inx 11257 30 flow flow NN cord-010092-uftc8inx 11257 31 cytometry cytometry NN cord-010092-uftc8inx 11257 32 . . . cord-010092-uftc8inx 11258 1 A a DT cord-010092-uftc8inx 11258 2 post post JJ cord-010092-uftc8inx 11258 3 transfusion transfusion NN cord-010092-uftc8inx 11258 4 platelet platelet NN cord-010092-uftc8inx 11258 5 count count NN cord-010092-uftc8inx 11258 6 of of IN cord-010092-uftc8inx 11258 7 more more JJR cord-010092-uftc8inx 11258 8 than than IN cord-010092-uftc8inx 11258 9 20 20 CD cord-010092-uftc8inx 11258 10 9 9 CD cord-010092-uftc8inx 11258 11 10 10 CD cord-010092-uftc8inx 11258 12 9 9 CD cord-010092-uftc8inx 11258 13 /L /L . cord-010092-uftc8inx 11258 14 might may MD cord-010092-uftc8inx 11258 15 be be VB cord-010092-uftc8inx 11258 16 sufficient sufficient JJ cord-010092-uftc8inx 11258 17 to to TO cord-010092-uftc8inx 11258 18 significantly significantly RB cord-010092-uftc8inx 11258 19 improve improve VB cord-010092-uftc8inx 11258 20 coagulation coagulation NN cord-010092-uftc8inx 11258 21 in in IN cord-010092-uftc8inx 11258 22 heavily heavily RB cord-010092-uftc8inx 11258 23 thrombocytopenic thrombocytopenic JJ cord-010092-uftc8inx 11258 24 patients patient NNS cord-010092-uftc8inx 11258 25 , , , cord-010092-uftc8inx 11258 26 but but CC cord-010092-uftc8inx 11258 27 larger large JJR cord-010092-uftc8inx 11258 28 studies study NNS cord-010092-uftc8inx 11258 29 are be VBP cord-010092-uftc8inx 11258 30 needed need VBN cord-010092-uftc8inx 11258 31 to to TO cord-010092-uftc8inx 11258 32 confirm confirm VB cord-010092-uftc8inx 11258 33 this this DT cord-010092-uftc8inx 11258 34 conclusion conclusion NN cord-010092-uftc8inx 11258 35 . . . cord-010092-uftc8inx 11259 1 Abstract Abstract NNP cord-010092-uftc8inx 11259 2 withdrawn withdraw VBN cord-010092-uftc8inx 11259 3 . . . cord-010092-uftc8inx 11260 1 Abstract Abstract NNP cord-010092-uftc8inx 11260 2 withdrawn withdraw VBN cord-010092-uftc8inx 11260 3 . . . cord-010092-uftc8inx 11261 1 Background background NN cord-010092-uftc8inx 11261 2 : : : cord-010092-uftc8inx 11262 1 Sickle sickle NN cord-010092-uftc8inx 11262 2 cell cell NN cord-010092-uftc8inx 11262 3 disease disease NN cord-010092-uftc8inx 11262 4 ( ( -LRB- cord-010092-uftc8inx 11262 5 SCD SCD NNP cord-010092-uftc8inx 11262 6 ) ) -RRB- cord-010092-uftc8inx 11262 7 is be VBZ cord-010092-uftc8inx 11262 8 a a DT cord-010092-uftc8inx 11262 9 genetic genetic JJ cord-010092-uftc8inx 11262 10 disorder disorder NN cord-010092-uftc8inx 11262 11 that that WDT cord-010092-uftc8inx 11262 12 is be VBZ cord-010092-uftc8inx 11262 13 frequently frequently RB cord-010092-uftc8inx 11262 14 referred refer VBN cord-010092-uftc8inx 11262 15 to to IN cord-010092-uftc8inx 11262 16 as as IN cord-010092-uftc8inx 11262 17 a a DT cord-010092-uftc8inx 11262 18 hypercoagulable hypercoagulable JJ cord-010092-uftc8inx 11262 19 state state NN cord-010092-uftc8inx 11262 20 . . . cord-010092-uftc8inx 11263 1 Hydroxyurea Hydroxyurea NNP cord-010092-uftc8inx 11263 2 ( ( -LRB- cord-010092-uftc8inx 11263 3 HU HU NNP cord-010092-uftc8inx 11263 4 ) ) -RRB- cord-010092-uftc8inx 11263 5 is be VBZ cord-010092-uftc8inx 11263 6 known know VBN cord-010092-uftc8inx 11263 7 to to TO cord-010092-uftc8inx 11263 8 decrease decrease VB cord-010092-uftc8inx 11263 9 the the DT cord-010092-uftc8inx 11263 10 frequency frequency NN cord-010092-uftc8inx 11263 11 of of IN cord-010092-uftc8inx 11263 12 vaso vaso JJ cord-010092-uftc8inx 11263 13 - - HYPH cord-010092-uftc8inx 11263 14 occlusive occlusive JJ cord-010092-uftc8inx 11263 15 complications complication NNS cord-010092-uftc8inx 11263 16 and and CC cord-010092-uftc8inx 11263 17 need need VBP cord-010092-uftc8inx 11263 18 for for IN cord-010092-uftc8inx 11263 19 blood blood NN cord-010092-uftc8inx 11263 20 transfusions transfusion NNS cord-010092-uftc8inx 11263 21 in in IN cord-010092-uftc8inx 11263 22 severely severely RB cord-010092-uftc8inx 11263 23 affected affect VBN cord-010092-uftc8inx 11263 24 individuals individual NNS cord-010092-uftc8inx 11263 25 . . . cord-010092-uftc8inx 11264 1 Although although IN cord-010092-uftc8inx 11264 2 cross cross JJ cord-010092-uftc8inx 11264 3 - - JJ cord-010092-uftc8inx 11264 4 sectional sectional JJ cord-010092-uftc8inx 11264 5 studies study NNS cord-010092-uftc8inx 11264 6 show show VBP cord-010092-uftc8inx 11264 7 that that IN cord-010092-uftc8inx 11264 8 treatment treatment NN cord-010092-uftc8inx 11264 9 with with IN cord-010092-uftc8inx 11264 10 HU HU NNP cord-010092-uftc8inx 11264 11 is be VBZ cord-010092-uftc8inx 11264 12 associated associate VBN cord-010092-uftc8inx 11264 13 with with IN cord-010092-uftc8inx 11264 14 decreased decreased JJ cord-010092-uftc8inx 11264 15 coagulation coagulation NN cord-010092-uftc8inx 11264 16 activation activation NN cord-010092-uftc8inx 11264 17 , , , cord-010092-uftc8inx 11264 18 there there EX cord-010092-uftc8inx 11264 19 are be VBP cord-010092-uftc8inx 11264 20 no no DT cord-010092-uftc8inx 11264 21 prospective prospective JJ cord-010092-uftc8inx 11264 22 studies study NNS cord-010092-uftc8inx 11264 23 evaluating evaluate VBG cord-010092-uftc8inx 11264 24 the the DT cord-010092-uftc8inx 11264 25 effect effect NN cord-010092-uftc8inx 11264 26 of of IN cord-010092-uftc8inx 11264 27 HU HU NNP cord-010092-uftc8inx 11264 28 on on IN cord-010092-uftc8inx 11264 29 coagulation coagulation NN cord-010092-uftc8inx 11264 30 activation activation NN cord-010092-uftc8inx 11264 31 . . . cord-010092-uftc8inx 11265 1 Aims aim VBZ cord-010092-uftc8inx 11265 2 : : : cord-010092-uftc8inx 11265 3 To to TO cord-010092-uftc8inx 11265 4 assess assess VB cord-010092-uftc8inx 11265 5 the the DT cord-010092-uftc8inx 11265 6 effect effect NN cord-010092-uftc8inx 11265 7 of of IN cord-010092-uftc8inx 11265 8 HU HU NNP cord-010092-uftc8inx 11265 9 on on IN cord-010092-uftc8inx 11265 10 markers marker NNS cord-010092-uftc8inx 11265 11 of of IN cord-010092-uftc8inx 11265 12 fibrinolysis fibrinolysis NN cord-010092-uftc8inx 11265 13 ( ( -LRB- cord-010092-uftc8inx 11265 14 D d NN cord-010092-uftc8inx 11265 15 - - HYPH cord-010092-uftc8inx 11265 16 dimer dimer NN cord-010092-uftc8inx 11265 17 ) ) -RRB- cord-010092-uftc8inx 11265 18 and and CC cord-010092-uftc8inx 11265 19 endothelial endothelial JJ cord-010092-uftc8inx 11265 20 activation activation NN cord-010092-uftc8inx 11265 21 ( ( -LRB- cord-010092-uftc8inx 11265 22 soluble soluble JJ cord-010092-uftc8inx 11265 23 vascular vascular JJ cord-010092-uftc8inx 11265 24 cell cell NN cord-010092-uftc8inx 11265 25 adhesion adhesion NN cord-010092-uftc8inx 11265 26 molecule-1 molecule-1 NNP cord-010092-uftc8inx 11265 27 [ [ -LRB- cord-010092-uftc8inx 11265 28 soluble soluble JJ cord-010092-uftc8inx 11265 29 VCAM-1 VCAM-1 NNP cord-010092-uftc8inx 11265 30 ] ] -RRB- cord-010092-uftc8inx 11265 31 ) ) -RRB- cord-010092-uftc8inx 11265 32 in in IN cord-010092-uftc8inx 11265 33 patients patient NNS cord-010092-uftc8inx 11265 34 with with IN cord-010092-uftc8inx 11265 35 SCD SCD NNP cord-010092-uftc8inx 11265 36 in in IN cord-010092-uftc8inx 11265 37 their -PRON- PRP$ cord-010092-uftc8inx 11265 38 non non JJ cord-010092-uftc8inx 11265 39 - - JJ cord-010092-uftc8inx 11265 40 crisis crisis JJ cord-010092-uftc8inx 11265 41 , , , cord-010092-uftc8inx 11265 42 " " '' cord-010092-uftc8inx 11265 43 steady steady JJ cord-010092-uftc8inx 11265 44 state state NN cord-010092-uftc8inx 11265 45 . . . cord-010092-uftc8inx 11265 46 " " '' cord-010092-uftc8inx 11266 1 Methods method NNS cord-010092-uftc8inx 11266 2 : : : cord-010092-uftc8inx 11266 3 Patients patient NNS cord-010092-uftc8inx 11266 4 , , , cord-010092-uftc8inx 11266 5 at at RB cord-010092-uftc8inx 11266 6 least least RBS cord-010092-uftc8inx 11266 7 10 10 CD cord-010092-uftc8inx 11266 8 years year NNS cord-010092-uftc8inx 11266 9 of of IN cord-010092-uftc8inx 11266 10 age age NN cord-010092-uftc8inx 11266 11 , , , cord-010092-uftc8inx 11266 12 with with IN cord-010092-uftc8inx 11266 13 documented document VBN cord-010092-uftc8inx 11266 14 HbSS HbSS NNP cord-010092-uftc8inx 11266 15 or or CC cord-010092-uftc8inx 11266 16 HbSb HbSb NNP cord-010092-uftc8inx 11266 17 - - HYPH cord-010092-uftc8inx 11266 18 thalassemia thalassemia NN cord-010092-uftc8inx 11266 19 , , , cord-010092-uftc8inx 11266 20 eligible eligible JJ cord-010092-uftc8inx 11266 21 for for IN cord-010092-uftc8inx 11266 22 treatment treatment NN cord-010092-uftc8inx 11266 23 with with IN cord-010092-uftc8inx 11266 24 HU HU NNP cord-010092-uftc8inx 11266 25 were be VBD cord-010092-uftc8inx 11266 26 studied study VBN cord-010092-uftc8inx 11266 27 in in IN cord-010092-uftc8inx 11266 28 this this DT cord-010092-uftc8inx 11266 29 prospective prospective JJ cord-010092-uftc8inx 11266 30 , , , cord-010092-uftc8inx 11266 31 observational observational JJ cord-010092-uftc8inx 11266 32 study study NN cord-010092-uftc8inx 11266 33 . . . cord-010092-uftc8inx 11267 1 Laboratory laboratory NN cord-010092-uftc8inx 11267 2 investigations investigation NNS cord-010092-uftc8inx 11267 3 were be VBD cord-010092-uftc8inx 11267 4 obtained obtain VBN cord-010092-uftc8inx 11267 5 at at IN cord-010092-uftc8inx 11267 6 baseline baseline NN cord-010092-uftc8inx 11267 7 , , , cord-010092-uftc8inx 11267 8 prior prior RB cord-010092-uftc8inx 11267 9 to to IN cord-010092-uftc8inx 11267 10 commencement commencement NN cord-010092-uftc8inx 11267 11 of of IN cord-010092-uftc8inx 11267 12 therapy therapy NN cord-010092-uftc8inx 11267 13 with with IN cord-010092-uftc8inx 11267 14 HU HU NNP cord-010092-uftc8inx 11267 15 , , , cord-010092-uftc8inx 11267 16 with with IN cord-010092-uftc8inx 11267 17 repeat repeat NN cord-010092-uftc8inx 11267 18 evaluations evaluation NNS cord-010092-uftc8inx 11267 19 at at IN cord-010092-uftc8inx 11267 20 three three CD cord-010092-uftc8inx 11267 21 and and CC cord-010092-uftc8inx 11267 22 six six CD cord-010092-uftc8inx 11267 23 months month NNS cord-010092-uftc8inx 11267 24 of of IN cord-010092-uftc8inx 11267 25 therapy therapy NN cord-010092-uftc8inx 11267 26 . . . cord-010092-uftc8inx 11268 1 Non non JJ cord-010092-uftc8inx 11268 2 - - JJ cord-010092-uftc8inx 11268 3 parametric parametric JJ cord-010092-uftc8inx 11268 4 test test NN cord-010092-uftc8inx 11268 5 was be VBD cord-010092-uftc8inx 11268 6 applied apply VBN cord-010092-uftc8inx 11268 7 to to TO cord-010092-uftc8inx 11268 8 observe observe VB cord-010092-uftc8inx 11268 9 the the DT cord-010092-uftc8inx 11268 10 association association NN cord-010092-uftc8inx 11268 11 between between IN cord-010092-uftc8inx 11268 12 HU HU NNP cord-010092-uftc8inx 11268 13 therapy therapy NN cord-010092-uftc8inx 11268 14 and and CC cord-010092-uftc8inx 11268 15 the the DT cord-010092-uftc8inx 11268 16 biomarkers biomarker NNS cord-010092-uftc8inx 11268 17 of of IN cord-010092-uftc8inx 11268 18 interest interest NN cord-010092-uftc8inx 11268 19 . . . cord-010092-uftc8inx 11269 1 Results result NNS cord-010092-uftc8inx 11269 2 : : : cord-010092-uftc8inx 11270 1 Twenty twenty CD cord-010092-uftc8inx 11270 2 - - HYPH cord-010092-uftc8inx 11270 3 five five CD cord-010092-uftc8inx 11270 4 patients patient NNS cord-010092-uftc8inx 11270 5 with with IN cord-010092-uftc8inx 11270 6 SCD SCD NNP cord-010092-uftc8inx 11271 1 ( ( -LRB- cord-010092-uftc8inx 11271 2 HbSS HbSS NNP cord-010092-uftc8inx 11271 3 : : : cord-010092-uftc8inx 11271 4 15 15 CD cord-010092-uftc8inx 11271 5 , , , cord-010092-uftc8inx 11271 6 HbSb HbSb NNP cord-010092-uftc8inx 11271 7 thalassemia thalassemia NN cord-010092-uftc8inx 11271 8 : : : cord-010092-uftc8inx 11271 9 10 10 CD cord-010092-uftc8inx 11271 10 ) ) -RRB- cord-010092-uftc8inx 11271 11 were be VBD cord-010092-uftc8inx 11271 12 enrolled enrol VBN cord-010092-uftc8inx 11271 13 ( ( -LRB- cord-010092-uftc8inx 11271 14 females female NNS cord-010092-uftc8inx 11271 15 : : : cord-010092-uftc8inx 11271 16 15 15 CD cord-010092-uftc8inx 11271 17 [ [ -LRB- cord-010092-uftc8inx 11271 18 60 60 CD cord-010092-uftc8inx 11271 19 % % NN cord-010092-uftc8inx 11271 20 ] ] -RRB- cord-010092-uftc8inx 11271 21 ) ) -RRB- cord-010092-uftc8inx 11271 22 , , , cord-010092-uftc8inx 11271 23 with with IN cord-010092-uftc8inx 11271 24 a a DT cord-010092-uftc8inx 11271 25 median median JJ cord-010092-uftc8inx 11271 26 age age NN cord-010092-uftc8inx 11271 27 of of IN cord-010092-uftc8inx 11271 28 23 23 CD cord-010092-uftc8inx 11271 29 years year NNS cord-010092-uftc8inx 11271 30 ( ( -LRB- cord-010092-uftc8inx 11271 31 IQR iqr NN cord-010092-uftc8inx 11271 32 : : : cord-010092-uftc8inx 11271 33 11 11 CD cord-010092-uftc8inx 11271 34 ) ) -RRB- cord-010092-uftc8inx 11271 35 . . . cord-010092-uftc8inx 11272 1 Following follow VBG cord-010092-uftc8inx 11272 2 6 6 CD cord-010092-uftc8inx 11272 3 months month NNS cord-010092-uftc8inx 11272 4 of of IN cord-010092-uftc8inx 11272 5 HU HU NNP cord-010092-uftc8inx 11272 6 , , , cord-010092-uftc8inx 11272 7 median median JJ cord-010092-uftc8inx 11272 8 values value NNS cord-010092-uftc8inx 11272 9 for for IN cord-010092-uftc8inx 11272 10 WBC WBC NNP cord-010092-uftc8inx 11272 11 count count NN cord-010092-uftc8inx 11272 12 ( ( -LRB- cord-010092-uftc8inx 11272 13 9.02 9.02 CD cord-010092-uftc8inx 11272 14 9 9 CD cord-010092-uftc8inx 11272 15 10 10 CD cord-010092-uftc8inx 11272 16 9 9 CD cord-010092-uftc8inx 11272 17 /L /L . cord-010092-uftc8inx 11272 18 vs. vs. NN cord-010092-uftc8inx 11272 19 7.22 7.22 CD cord-010092-uftc8inx 11272 20 9 9 CD cord-010092-uftc8inx 11272 21 10 10 CD cord-010092-uftc8inx 11272 22 9 9 CD cord-010092-uftc8inx 11272 23 /L /l CD cord-010092-uftc8inx 11272 24 , , , cord-010092-uftc8inx 11272 25 P p NN cord-010092-uftc8inx 11272 26 = = SYM cord-010092-uftc8inx 11272 27 0.007 0.007 CD cord-010092-uftc8inx 11272 28 ) ) -RRB- cord-010092-uftc8inx 11272 29 and and CC cord-010092-uftc8inx 11272 30 D d NN cord-010092-uftc8inx 11272 31 - - HYPH cord-010092-uftc8inx 11272 32 dimer dimer NN cord-010092-uftc8inx 11272 33 ( ( -LRB- cord-010092-uftc8inx 11272 34 1243.8 1243.8 CD cord-010092-uftc8inx 11272 35 ng ng NNP cord-010092-uftc8inx 11272 36 / / SYM cord-010092-uftc8inx 11272 37 mL ml NN cord-010092-uftc8inx 11272 38 vs. vs. NN cord-010092-uftc8inx 11273 1 830.2 830.2 CD cord-010092-uftc8inx 11273 2 ng ng NNP cord-010092-uftc8inx 11273 3 / / SYM cord-010092-uftc8inx 11273 4 mL mL NNP cord-010092-uftc8inx 11273 5 , , , cord-010092-uftc8inx 11273 6 P p NN cord-010092-uftc8inx 11273 7 = = SYM cord-010092-uftc8inx 11273 8 0.028 0.028 CD cord-010092-uftc8inx 11273 9 ) ) -RRB- cord-010092-uftc8inx 11273 10 were be VBD cord-010092-uftc8inx 11273 11 significantly significantly RB cord-010092-uftc8inx 11273 12 lower low JJR cord-010092-uftc8inx 11273 13 than than IN cord-010092-uftc8inx 11273 14 baseline baseline JJ cord-010092-uftc8inx 11273 15 values value NNS cord-010092-uftc8inx 11273 16 , , , cord-010092-uftc8inx 11273 17 while while IN cord-010092-uftc8inx 11273 18 the the DT cord-010092-uftc8inx 11273 19 mean mean JJ cord-010092-uftc8inx 11273 20 corpuscular corpuscular JJ cord-010092-uftc8inx 11273 21 volume volume NN cord-010092-uftc8inx 11273 22 ( ( -LRB- cord-010092-uftc8inx 11273 23 76.0 76.0 CD cord-010092-uftc8inx 11273 24 fL fL NNP cord-010092-uftc8inx 11273 25 vs. vs. FW cord-010092-uftc8inx 11273 26 88.0 88.0 CD cord-010092-uftc8inx 11273 27 fL fL NNP cord-010092-uftc8inx 11273 28 , , , cord-010092-uftc8inx 11273 29 P p NN cord-010092-uftc8inx 11273 30 = = SYM cord-010092-uftc8inx 11273 31 0.001 0.001 CD cord-010092-uftc8inx 11273 32 ) ) -RRB- cord-010092-uftc8inx 11273 33 was be VBD cord-010092-uftc8inx 11273 34 significantly significantly RB cord-010092-uftc8inx 11273 35 higher high JJR cord-010092-uftc8inx 11273 36 than than IN cord-010092-uftc8inx 11273 37 the the DT cord-010092-uftc8inx 11273 38 baseline baseline JJ cord-010092-uftc8inx 11273 39 value value NN cord-010092-uftc8inx 11273 40 . . . cord-010092-uftc8inx 11274 1 No no DT cord-010092-uftc8inx 11274 2 significant significant JJ cord-010092-uftc8inx 11274 3 differences difference NNS cord-010092-uftc8inx 11274 4 from from IN cord-010092-uftc8inx 11274 5 baseline baseline NN cord-010092-uftc8inx 11274 6 were be VBD cord-010092-uftc8inx 11274 7 observed observe VBN cord-010092-uftc8inx 11274 8 in in IN cord-010092-uftc8inx 11274 9 the the DT cord-010092-uftc8inx 11274 10 median median JJ cord-010092-uftc8inx 11274 11 values value NNS cord-010092-uftc8inx 11274 12 for for IN cord-010092-uftc8inx 11274 13 hemoglobin hemoglobin NN cord-010092-uftc8inx 11275 1 ( ( -LRB- cord-010092-uftc8inx 11275 2 9.1 9.1 CD cord-010092-uftc8inx 11275 3 g/ g/ JJ cord-010092-uftc8inx 11275 4 dL dl NN cord-010092-uftc8inx 11275 5 vs. vs. FW cord-010092-uftc8inx 11275 6 9.6 9.6 CD cord-010092-uftc8inx 11275 7 g g NN cord-010092-uftc8inx 11275 8 / / SYM cord-010092-uftc8inx 11275 9 dL dl NN cord-010092-uftc8inx 11275 10 , , , cord-010092-uftc8inx 11275 11 P p NN cord-010092-uftc8inx 11275 12 = = SYM cord-010092-uftc8inx 11275 13 0.72 0.72 CD cord-010092-uftc8inx 11275 14 ) ) -RRB- cord-010092-uftc8inx 11275 15 , , , cord-010092-uftc8inx 11275 16 platelet platelet NN cord-010092-uftc8inx 11275 17 count count NN cord-010092-uftc8inx 11275 18 ( ( -LRB- cord-010092-uftc8inx 11275 19 250 250 CD cord-010092-uftc8inx 11275 20 10 10 CD cord-010092-uftc8inx 11275 21 9 9 CD cord-010092-uftc8inx 11275 22 /L /L . cord-010092-uftc8inx 11275 23 vs. vs. FW cord-010092-uftc8inx 11275 24 196.5 196.5 CD cord-010092-uftc8inx 11275 25 10 10 CD cord-010092-uftc8inx 11275 26 9 9 CD cord-010092-uftc8inx 11275 27 /L /l CD cord-010092-uftc8inx 11275 28 , , , cord-010092-uftc8inx 11275 29 P p NN cord-010092-uftc8inx 11275 30 = = SYM cord-010092-uftc8inx 11275 31 0.71 0.71 CD cord-010092-uftc8inx 11275 32 ) ) -RRB- cord-010092-uftc8inx 11275 33 , , , cord-010092-uftc8inx 11275 34 lactate lactate NN cord-010092-uftc8inx 11275 35 dehydrogenase dehydrogenase NN cord-010092-uftc8inx 11275 36 ( ( -LRB- cord-010092-uftc8inx 11275 37 744 744 CD cord-010092-uftc8inx 11275 38 U U NNP cord-010092-uftc8inx 11275 39 / / SYM cord-010092-uftc8inx 11275 40 L l NN cord-010092-uftc8inx 11275 41 vs. vs. FW cord-010092-uftc8inx 11275 42 567.5 567.5 CD cord-010092-uftc8inx 11275 43 U U NNP cord-010092-uftc8inx 11275 44 / / SYM cord-010092-uftc8inx 11275 45 L L NNP cord-010092-uftc8inx 11275 46 , , , cord-010092-uftc8inx 11275 47 P p NN cord-010092-uftc8inx 11275 48 = = SYM cord-010092-uftc8inx 11275 49 0.23 0.23 CD cord-010092-uftc8inx 11275 50 ) ) -RRB- cord-010092-uftc8inx 11275 51 or or CC cord-010092-uftc8inx 11275 52 soluble soluble JJ cord-010092-uftc8inx 11275 53 VCAM-1 VCAM-1 NNS cord-010092-uftc8inx 11275 54 ( ( -LRB- cord-010092-uftc8inx 11275 55 567.8 567.8 CD cord-010092-uftc8inx 11275 56 ng/ ng/ NN cord-010092-uftc8inx 11275 57 mL ml NN cord-010092-uftc8inx 11275 58 vs. vs. JJ cord-010092-uftc8inx 11275 59 526.4 526.4 CD cord-010092-uftc8inx 11275 60 ng ng NNP cord-010092-uftc8inx 11275 61 / / SYM cord-010092-uftc8inx 11275 62 mL mL NNP cord-010092-uftc8inx 11275 63 , , , cord-010092-uftc8inx 11275 64 P p NN cord-010092-uftc8inx 11275 65 = = SYM cord-010092-uftc8inx 11275 66 0.33 0.33 CD cord-010092-uftc8inx 11275 67 ) ) -RRB- cord-010092-uftc8inx 11275 68 following follow VBG cord-010092-uftc8inx 11275 69 6 6 CD cord-010092-uftc8inx 11275 70 months month NNS cord-010092-uftc8inx 11275 71 of of IN cord-010092-uftc8inx 11275 72 HU HU NNP cord-010092-uftc8inx 11275 73 therapy therapy NN cord-010092-uftc8inx 11275 74 . . . cord-010092-uftc8inx 11276 1 Summary Summary NNP cord-010092-uftc8inx 11276 2 / / SYM cord-010092-uftc8inx 11276 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 11276 4 : : : cord-010092-uftc8inx 11277 1 This this DT cord-010092-uftc8inx 11277 2 exploratory exploratory JJ cord-010092-uftc8inx 11277 3 study study NN cord-010092-uftc8inx 11277 4 confirms confirm VBZ cord-010092-uftc8inx 11277 5 that that IN cord-010092-uftc8inx 11277 6 treatment treatment NN cord-010092-uftc8inx 11277 7 with with IN cord-010092-uftc8inx 11277 8 HU HU NNP cord-010092-uftc8inx 11277 9 is be VBZ cord-010092-uftc8inx 11277 10 associated associate VBN cord-010092-uftc8inx 11277 11 with with IN cord-010092-uftc8inx 11277 12 decreased decreased JJ cord-010092-uftc8inx 11277 13 coagulation coagulation NN cord-010092-uftc8inx 11277 14 activation activation NN cord-010092-uftc8inx 11277 15 in in IN cord-010092-uftc8inx 11277 16 patients patient NNS cord-010092-uftc8inx 11277 17 with with IN cord-010092-uftc8inx 11277 18 SCD SCD NNP cord-010092-uftc8inx 11277 19 , , , cord-010092-uftc8inx 11277 20 although although IN cord-010092-uftc8inx 11277 21 no no DT cord-010092-uftc8inx 11277 22 effect effect NN cord-010092-uftc8inx 11277 23 on on IN cord-010092-uftc8inx 11277 24 endothelial endothelial JJ cord-010092-uftc8inx 11277 25 activation activation NN cord-010092-uftc8inx 11277 26 was be VBD cord-010092-uftc8inx 11277 27 observed observe VBN cord-010092-uftc8inx 11277 28 . . . cord-010092-uftc8inx 11278 1 By by IN cord-010092-uftc8inx 11278 2 decreasing decrease VBG cord-010092-uftc8inx 11278 3 coagulation coagulation NN cord-010092-uftc8inx 11278 4 activation activation NN cord-010092-uftc8inx 11278 5 , , , cord-010092-uftc8inx 11278 6 HU HU NNP cord-010092-uftc8inx 11278 7 may may MD cord-010092-uftc8inx 11278 8 decrease decrease VB cord-010092-uftc8inx 11278 9 the the DT cord-010092-uftc8inx 11278 10 risk risk NN cord-010092-uftc8inx 11278 11 of of IN cord-010092-uftc8inx 11278 12 thrombotic thrombotic JJ cord-010092-uftc8inx 11278 13 complications complication NNS cord-010092-uftc8inx 11278 14 in in IN cord-010092-uftc8inx 11278 15 SCD SCD NNP cord-010092-uftc8inx 11278 16 . . . cord-010092-uftc8inx 11279 1 Abstract Abstract NNP cord-010092-uftc8inx 11279 2 withdrawn withdraw VBN cord-010092-uftc8inx 11279 3 . . . cord-010092-uftc8inx 11280 1 Abstract Abstract NNP cord-010092-uftc8inx 11280 2 withdrawn withdraw VBN cord-010092-uftc8inx 11280 3 . . . cord-010092-uftc8inx 11281 1 Transfusion Transfusion NNP cord-010092-uftc8inx 11281 2 Medicine Medicine NNP cord-010092-uftc8inx 11281 3 , , , cord-010092-uftc8inx 11281 4 Apollo Apollo NNP cord-010092-uftc8inx 11281 5 Gleneagles Gleneagles NNP cord-010092-uftc8inx 11281 6 Hospitals Hospitals NNPS cord-010092-uftc8inx 11281 7 , , , cord-010092-uftc8inx 11281 8 Kolkata Kolkata NNP cord-010092-uftc8inx 11281 9 , , , cord-010092-uftc8inx 11281 10 India India NNP cord-010092-uftc8inx 11281 11 Background Background NNP cord-010092-uftc8inx 11281 12 : : : cord-010092-uftc8inx 11281 13 Reduction reduction NN cord-010092-uftc8inx 11281 14 of of IN cord-010092-uftc8inx 11281 15 immune immune JJ cord-010092-uftc8inx 11281 16 responsiveness responsiveness NN cord-010092-uftc8inx 11281 17 through through IN cord-010092-uftc8inx 11281 18 blood blood NN cord-010092-uftc8inx 11281 19 transfusion transfusion NN cord-010092-uftc8inx 11281 20 has have VBZ cord-010092-uftc8inx 11281 21 been be VBN cord-010092-uftc8inx 11281 22 documented document VBN cord-010092-uftc8inx 11281 23 by by IN cord-010092-uftc8inx 11281 24 previous previous JJ cord-010092-uftc8inx 11281 25 authors author NNS cord-010092-uftc8inx 11281 26 . . . cord-010092-uftc8inx 11282 1 Breast breast NN cord-010092-uftc8inx 11282 2 cancer cancer NN cord-010092-uftc8inx 11282 3 is be VBZ cord-010092-uftc8inx 11282 4 considered consider VBN cord-010092-uftc8inx 11282 5 as as IN cord-010092-uftc8inx 11282 6 one one CD cord-010092-uftc8inx 11282 7 of of IN cord-010092-uftc8inx 11282 8 the the DT cord-010092-uftc8inx 11282 9 commonest common JJS cord-010092-uftc8inx 11282 10 cancer cancer NN cord-010092-uftc8inx 11282 11 globally globally RB cord-010092-uftc8inx 11282 12 and and CC cord-010092-uftc8inx 11282 13 the the DT cord-010092-uftc8inx 11282 14 second second JJ cord-010092-uftc8inx 11282 15 main main JJ cord-010092-uftc8inx 11282 16 cause cause NN cord-010092-uftc8inx 11282 17 of of IN cord-010092-uftc8inx 11282 18 death death NN cord-010092-uftc8inx 11282 19 in in IN cord-010092-uftc8inx 11282 20 females females JJ cord-010092-uftc8inx 11282 21 Transfusion transfusion NN cord-010092-uftc8inx 11282 22 of of IN cord-010092-uftc8inx 11282 23 allogeneic allogeneic NN cord-010092-uftc8inx 11282 24 blood blood NN cord-010092-uftc8inx 11282 25 in in IN cord-010092-uftc8inx 11282 26 breast breast NN cord-010092-uftc8inx 11282 27 cancer cancer NN cord-010092-uftc8inx 11282 28 surgery surgery NN cord-010092-uftc8inx 11282 29 is be VBZ cord-010092-uftc8inx 11282 30 variable variable JJ cord-010092-uftc8inx 11282 31 and and CC cord-010092-uftc8inx 11282 32 differences difference NNS cord-010092-uftc8inx 11282 33 of of IN cord-010092-uftc8inx 11282 34 transfusion transfusion NN cord-010092-uftc8inx 11282 35 incidence incidence NN cord-010092-uftc8inx 11282 36 have have VBP cord-010092-uftc8inx 11282 37 been be VBN cord-010092-uftc8inx 11282 38 observed observe VBN cord-010092-uftc8inx 11282 39 in in IN cord-010092-uftc8inx 11282 40 the the DT cord-010092-uftc8inx 11282 41 literature literature NN cord-010092-uftc8inx 11282 42 . . . cord-010092-uftc8inx 11283 1 Where where WRB cord-010092-uftc8inx 11283 2 the the DT cord-010092-uftc8inx 11283 3 maximum maximum JJ cord-010092-uftc8inx 11283 4 surgical surgical JJ cord-010092-uftc8inx 11283 5 blood blood NN cord-010092-uftc8inx 11283 6 ordering ordering NN cord-010092-uftc8inx 11283 7 schedule schedule NN cord-010092-uftc8inx 11283 8 ( ( -LRB- cord-010092-uftc8inx 11283 9 MSBOS MSBOS NNP cord-010092-uftc8inx 11283 10 ) ) -RRB- cord-010092-uftc8inx 11283 11 dictates dictate VBZ cord-010092-uftc8inx 11283 12 cross cross NN cord-010092-uftc8inx 11283 13 matching matching NN cord-010092-uftc8inx 11283 14 and and CC cord-010092-uftc8inx 11283 15 reservation reservation NN cord-010092-uftc8inx 11283 16 of of IN cord-010092-uftc8inx 11283 17 blood blood NN cord-010092-uftc8inx 11283 18 before before IN cord-010092-uftc8inx 11283 19 surgery surgery NN cord-010092-uftc8inx 11283 20 , , , cord-010092-uftc8inx 11283 21 factors factor NNS cord-010092-uftc8inx 11283 22 deciding decide VBG cord-010092-uftc8inx 11283 23 their -PRON- PRP$ cord-010092-uftc8inx 11283 24 utilization utilization NN cord-010092-uftc8inx 11283 25 are be VBP cord-010092-uftc8inx 11283 26 varied varied JJ cord-010092-uftc8inx 11283 27 and and CC cord-010092-uftc8inx 11283 28 numerous numerous JJ cord-010092-uftc8inx 11283 29 . . . cord-010092-uftc8inx 11284 1 Our -PRON- PRP$ cord-010092-uftc8inx 11284 2 hospital hospital NN cord-010092-uftc8inx 11284 3 protocol protocol NN cord-010092-uftc8inx 11284 4 guides guide VBZ cord-010092-uftc8inx 11284 5 that that IN cord-010092-uftc8inx 11284 6 every every DT cord-010092-uftc8inx 11284 7 patient patient NN cord-010092-uftc8inx 11284 8 planned plan VBN cord-010092-uftc8inx 11284 9 for for IN cord-010092-uftc8inx 11284 10 elective elective JJ cord-010092-uftc8inx 11284 11 breast breast NN cord-010092-uftc8inx 11284 12 cancer cancer NN cord-010092-uftc8inx 11284 13 surgery surgery NN cord-010092-uftc8inx 11284 14 should should MD cord-010092-uftc8inx 11284 15 routinely routinely RB cord-010092-uftc8inx 11284 16 have have VB cord-010092-uftc8inx 11284 17 a a DT cord-010092-uftc8inx 11284 18 blood blood NN cord-010092-uftc8inx 11284 19 sample sample NN cord-010092-uftc8inx 11284 20 sent send VBN cord-010092-uftc8inx 11284 21 for for IN cord-010092-uftc8inx 11284 22 reservation reservation NN cord-010092-uftc8inx 11284 23 of of IN cord-010092-uftc8inx 11284 24 one one CD cord-010092-uftc8inx 11284 25 unit unit NN cord-010092-uftc8inx 11284 26 of of IN cord-010092-uftc8inx 11284 27 compatible compatible JJ cord-010092-uftc8inx 11284 28 packed packed JJ cord-010092-uftc8inx 11284 29 red red JJ cord-010092-uftc8inx 11284 30 blood blood NN cord-010092-uftc8inx 11284 31 cell cell NN cord-010092-uftc8inx 11284 32 ( ( -LRB- cord-010092-uftc8inx 11284 33 PRBC PRBC NNP cord-010092-uftc8inx 11284 34 ) ) -RRB- cord-010092-uftc8inx 11284 35 in in IN cord-010092-uftc8inx 11284 36 the the DT cord-010092-uftc8inx 11284 37 blood blood NN cord-010092-uftc8inx 11284 38 bank bank NN cord-010092-uftc8inx 11284 39 . . . cord-010092-uftc8inx 11285 1 Aims aim VBZ cord-010092-uftc8inx 11285 2 : : : cord-010092-uftc8inx 11286 1 In in IN cord-010092-uftc8inx 11286 2 this this DT cord-010092-uftc8inx 11286 3 prospective prospective JJ cord-010092-uftc8inx 11286 4 study study NN cord-010092-uftc8inx 11286 5 we -PRON- PRP cord-010092-uftc8inx 11286 6 aimed aim VBD cord-010092-uftc8inx 11286 7 to to TO cord-010092-uftc8inx 11286 8 audit audit VB cord-010092-uftc8inx 11286 9 the the DT cord-010092-uftc8inx 11286 10 blood blood NN cord-010092-uftc8inx 11286 11 utilization utilization NN cord-010092-uftc8inx 11286 12 in in IN cord-010092-uftc8inx 11286 13 patients patient NNS cord-010092-uftc8inx 11286 14 undergoing undergo VBG cord-010092-uftc8inx 11286 15 elective elective JJ cord-010092-uftc8inx 11286 16 breast breast NN cord-010092-uftc8inx 11286 17 surgery surgery NN cord-010092-uftc8inx 11286 18 and and CC cord-010092-uftc8inx 11286 19 thereby thereby RB cord-010092-uftc8inx 11286 20 optimize optimize VB cord-010092-uftc8inx 11286 21 the the DT cord-010092-uftc8inx 11286 22 blood blood NN cord-010092-uftc8inx 11286 23 ordering ordering NN cord-010092-uftc8inx 11286 24 schedule schedule NN cord-010092-uftc8inx 11286 25 , , , cord-010092-uftc8inx 11286 26 economic economic JJ cord-010092-uftc8inx 11286 27 burden burden NN cord-010092-uftc8inx 11286 28 and and CC cord-010092-uftc8inx 11286 29 loss loss NN cord-010092-uftc8inx 11286 30 of of IN cord-010092-uftc8inx 11286 31 clinical clinical JJ cord-010092-uftc8inx 11286 32 resources resource NNS cord-010092-uftc8inx 11286 33 . . . cord-010092-uftc8inx 11287 1 Methods method NNS cord-010092-uftc8inx 11287 2 : : : cord-010092-uftc8inx 11288 1 The the DT cord-010092-uftc8inx 11288 2 study study NN cord-010092-uftc8inx 11288 3 included include VBD cord-010092-uftc8inx 11288 4 478 478 CD cord-010092-uftc8inx 11288 5 confirmed confirm VBD cord-010092-uftc8inx 11288 6 breast breast NN cord-010092-uftc8inx 11288 7 cancer cancer NN cord-010092-uftc8inx 11288 8 patients patient NNS cord-010092-uftc8inx 11288 9 planned plan VBN cord-010092-uftc8inx 11288 10 for for IN cord-010092-uftc8inx 11288 11 elective elective JJ cord-010092-uftc8inx 11288 12 breast breast NN cord-010092-uftc8inx 11288 13 surgeries surgery NNS cord-010092-uftc8inx 11288 14 from from IN cord-010092-uftc8inx 11288 15 January January NNP cord-010092-uftc8inx 11288 16 2012 2012 CD cord-010092-uftc8inx 11288 17 to to IN cord-010092-uftc8inx 11288 18 December December NNP cord-010092-uftc8inx 11288 19 2017 2017 CD cord-010092-uftc8inx 11288 20 . . . cord-010092-uftc8inx 11289 1 Patient patient JJ cord-010092-uftc8inx 11289 2 and and CC cord-010092-uftc8inx 11289 3 disease disease NN cord-010092-uftc8inx 11289 4 details detail NNS cord-010092-uftc8inx 11289 5 like like IN cord-010092-uftc8inx 11289 6 age age NN cord-010092-uftc8inx 11289 7 , , , cord-010092-uftc8inx 11289 8 stage stage NN cord-010092-uftc8inx 11289 9 , , , cord-010092-uftc8inx 11289 10 TNM tnm NN cord-010092-uftc8inx 11289 11 status status NN cord-010092-uftc8inx 11289 12 , , , cord-010092-uftc8inx 11289 13 estrogen estrogen NN cord-010092-uftc8inx 11289 14 receptor receptor NN cord-010092-uftc8inx 11289 15 ( ( -LRB- cord-010092-uftc8inx 11289 16 ER ER NNP cord-010092-uftc8inx 11289 17 ) ) -RRB- cord-010092-uftc8inx 11289 18 and and CC cord-010092-uftc8inx 11289 19 progesterone progesterone NN cord-010092-uftc8inx 11289 20 receptor receptor NN cord-010092-uftc8inx 11289 21 ( ( -LRB- cord-010092-uftc8inx 11289 22 PR PR NNP cord-010092-uftc8inx 11289 23 ) ) -RRB- cord-010092-uftc8inx 11289 24 status status NN cord-010092-uftc8inx 11289 25 , , , cord-010092-uftc8inx 11289 26 human human JJ cord-010092-uftc8inx 11289 27 epidermal epidermal JJ cord-010092-uftc8inx 11289 28 growth growth NN cord-010092-uftc8inx 11289 29 factor factor NN cord-010092-uftc8inx 11289 30 receptor receptor NN cord-010092-uftc8inx 11289 31 2 2 CD cord-010092-uftc8inx 11289 32 ( ( -LRB- cord-010092-uftc8inx 11289 33 HER her PRP$ cord-010092-uftc8inx 11289 34 -2 -2 CD cord-010092-uftc8inx 11289 35 ) ) -RRB- cord-010092-uftc8inx 11289 36 expression expression NN cord-010092-uftc8inx 11289 37 , , , cord-010092-uftc8inx 11289 38 triple triple JJ cord-010092-uftc8inx 11289 39 negative negative JJ cord-010092-uftc8inx 11289 40 breast breast NN cord-010092-uftc8inx 11289 41 cancer cancer NN cord-010092-uftc8inx 11289 42 ( ( -LRB- cord-010092-uftc8inx 11289 43 TNBC TNBC NNP cord-010092-uftc8inx 11289 44 ) ) -RRB- cord-010092-uftc8inx 11289 45 status status NN cord-010092-uftc8inx 11289 46 , , , cord-010092-uftc8inx 11289 47 reproductive reproductive JJ cord-010092-uftc8inx 11289 48 and and CC cord-010092-uftc8inx 11289 49 treatment treatment NN cord-010092-uftc8inx 11289 50 status status NN cord-010092-uftc8inx 11289 51 were be VBD cord-010092-uftc8inx 11289 52 documented document VBN cord-010092-uftc8inx 11289 53 . . . cord-010092-uftc8inx 11290 1 Patients patient NNS cord-010092-uftc8inx 11290 2 were be VBD cord-010092-uftc8inx 11290 3 divided divide VBN cord-010092-uftc8inx 11290 4 into into IN cord-010092-uftc8inx 11290 5 younger young JJR cord-010092-uftc8inx 11290 6 group group NN cord-010092-uftc8inx 11290 7 [ [ -LRB- cord-010092-uftc8inx 11290 8 ≤40 ≤40 NN cord-010092-uftc8inx 11290 9 years year NNS cord-010092-uftc8inx 11290 10 ] ] -RRB- cord-010092-uftc8inx 11290 11 and and CC cord-010092-uftc8inx 11290 12 older old JJR cord-010092-uftc8inx 11290 13 group group NN cord-010092-uftc8inx 11290 14 ( ( -LRB- cord-010092-uftc8inx 11290 15 > > NFP cord-010092-uftc8inx 11290 16 40 40 CD cord-010092-uftc8inx 11290 17 years year NNS cord-010092-uftc8inx 11290 18 ) ) -RRB- cord-010092-uftc8inx 11290 19 . . . cord-010092-uftc8inx 11291 1 Before before IN cord-010092-uftc8inx 11291 2 surgery surgery NN cord-010092-uftc8inx 11291 3 blood blood NN cord-010092-uftc8inx 11291 4 samples sample NNS cord-010092-uftc8inx 11291 5 for for IN cord-010092-uftc8inx 11291 6 compatibility compatibility NN cord-010092-uftc8inx 11291 7 testing testing NN cord-010092-uftc8inx 11291 8 were be VBD cord-010092-uftc8inx 11291 9 sent send VBN cord-010092-uftc8inx 11291 10 to to IN cord-010092-uftc8inx 11291 11 blood blood NN cord-010092-uftc8inx 11291 12 bank bank NN cord-010092-uftc8inx 11291 13 for for IN cord-010092-uftc8inx 11291 14 blood blood NN cord-010092-uftc8inx 11291 15 reservation reservation NN cord-010092-uftc8inx 11291 16 . . . cord-010092-uftc8inx 11292 1 Details detail NNS cord-010092-uftc8inx 11292 2 of of IN cord-010092-uftc8inx 11292 3 test test NN cord-010092-uftc8inx 11292 4 , , , cord-010092-uftc8inx 11292 5 blood blood NN cord-010092-uftc8inx 11292 6 issue issue NN cord-010092-uftc8inx 11292 7 and and CC cord-010092-uftc8inx 11292 8 blood blood NN cord-010092-uftc8inx 11292 9 transfusion transfusion NN cord-010092-uftc8inx 11292 10 were be VBD cord-010092-uftc8inx 11292 11 documented document VBN cord-010092-uftc8inx 11292 12 in in IN cord-010092-uftc8inx 11292 13 the the DT cord-010092-uftc8inx 11292 14 blood blood NN cord-010092-uftc8inx 11292 15 bank bank NN cord-010092-uftc8inx 11292 16 . . . cord-010092-uftc8inx 11293 1 Approximate approximate JJ cord-010092-uftc8inx 11293 2 loss loss NN cord-010092-uftc8inx 11293 3 of of IN cord-010092-uftc8inx 11293 4 time time NN cord-010092-uftc8inx 11293 5 in in IN cord-010092-uftc8inx 11293 6 minutes minute NNS cord-010092-uftc8inx 11293 7 and and CC cord-010092-uftc8inx 11293 8 wastage wastage NN cord-010092-uftc8inx 11293 9 of of IN cord-010092-uftc8inx 11293 10 resources resource NNS cord-010092-uftc8inx 11293 11 in in IN cord-010092-uftc8inx 11293 12 terms term NNS cord-010092-uftc8inx 11293 13 of of IN cord-010092-uftc8inx 11293 14 money money NN cord-010092-uftc8inx 11293 15 ( ( -LRB- cord-010092-uftc8inx 11293 16 INR INR NNP cord-010092-uftc8inx 11293 17 ) ) -RRB- cord-010092-uftc8inx 11293 18 in in IN cord-010092-uftc8inx 11293 19 the the DT cord-010092-uftc8inx 11293 20 blood blood NN cord-010092-uftc8inx 11293 21 bank bank NN cord-010092-uftc8inx 11293 22 were be VBD cord-010092-uftc8inx 11293 23 noted note VBN cord-010092-uftc8inx 11293 24 . . . cord-010092-uftc8inx 11294 1 All all DT cord-010092-uftc8inx 11294 2 results result NNS cord-010092-uftc8inx 11294 3 were be VBD cord-010092-uftc8inx 11294 4 calculated calculate VBN cord-010092-uftc8inx 11294 5 as as IN cord-010092-uftc8inx 11294 6 mean mean JJ cord-010092-uftc8inx 11294 7 AE AE NNP cord-010092-uftc8inx 11294 8 SD SD NNP cord-010092-uftc8inx 11294 9 and and CC cord-010092-uftc8inx 11294 10 a a DT cord-010092-uftc8inx 11294 11 ' ' `` cord-010092-uftc8inx 11294 12 P p NN cord-010092-uftc8inx 11294 13 ' ' '' cord-010092-uftc8inx 11294 14 value value NN cord-010092-uftc8inx 11294 15 of of IN cord-010092-uftc8inx 11294 16 < < NNP cord-010092-uftc8inx 11294 17 0.05 0.05 CD cord-010092-uftc8inx 11294 18 was be VBD cord-010092-uftc8inx 11294 19 considered consider VBN cord-010092-uftc8inx 11294 20 statistically statistically RB cord-010092-uftc8inx 11294 21 significant significant JJ cord-010092-uftc8inx 11294 22 . . . cord-010092-uftc8inx 11295 1 Results result NNS cord-010092-uftc8inx 11295 2 : : : cord-010092-uftc8inx 11296 1 Of of IN cord-010092-uftc8inx 11296 2 the the DT cord-010092-uftc8inx 11296 3 total total JJ cord-010092-uftc8inx 11296 4 478 478 CD cord-010092-uftc8inx 11296 5 patients patient NNS cord-010092-uftc8inx 11296 6 most most RBS cord-010092-uftc8inx 11296 7 underwent undergo VBD cord-010092-uftc8inx 11296 8 wide wide JJ cord-010092-uftc8inx 11296 9 local local JJ cord-010092-uftc8inx 11296 10 excision excision NN cord-010092-uftc8inx 11296 11 of of IN cord-010092-uftc8inx 11296 12 the the DT cord-010092-uftc8inx 11296 13 breast breast NN cord-010092-uftc8inx 11296 14 and and CC cord-010092-uftc8inx 11296 15 modified modify VBN cord-010092-uftc8inx 11296 16 radical radical JJ cord-010092-uftc8inx 11296 17 mastectomy mastectomy NN cord-010092-uftc8inx 11296 18 . . . cord-010092-uftc8inx 11297 1 A a DT cord-010092-uftc8inx 11297 2 total total NN cord-010092-uftc8inx 11297 3 of of IN cord-010092-uftc8inx 11297 4 16 16 CD cord-010092-uftc8inx 11297 5 patients patient NNS cord-010092-uftc8inx 11297 6 received receive VBD cord-010092-uftc8inx 11297 7 71 71 CD cord-010092-uftc8inx 11297 8 units unit NNS cord-010092-uftc8inx 11297 9 of of IN cord-010092-uftc8inx 11297 10 blood blood NN cord-010092-uftc8inx 11297 11 and and CC cord-010092-uftc8inx 11297 12 blood blood NN cord-010092-uftc8inx 11297 13 components component NNS cord-010092-uftc8inx 11297 14 in in IN cord-010092-uftc8inx 11297 15 all all DT cord-010092-uftc8inx 11297 16 categories category NNS cord-010092-uftc8inx 11297 17 of of IN cord-010092-uftc8inx 11297 18 surgeries surgery NNS cord-010092-uftc8inx 11297 19 . . . cord-010092-uftc8inx 11298 1 Only only RB cord-010092-uftc8inx 11298 2 103 103 CD cord-010092-uftc8inx 11298 3 were be VBD cord-010092-uftc8inx 11298 4 younger young JJR cord-010092-uftc8inx 11298 5 women woman NNS cord-010092-uftc8inx 11298 6 ( ( -LRB- cord-010092-uftc8inx 11298 7 ≤40 ≤40 NN cord-010092-uftc8inx 11298 8 years year NNS cord-010092-uftc8inx 11298 9 ) ) -RRB- cord-010092-uftc8inx 11298 10 with with IN cord-010092-uftc8inx 11298 11 mean mean JJ cord-010092-uftc8inx 11298 12 age age NN cord-010092-uftc8inx 11298 13 of of IN cord-010092-uftc8inx 11298 14 31 31 CD cord-010092-uftc8inx 11298 15 years year NNS cord-010092-uftc8inx 11298 16 . . . cord-010092-uftc8inx 11299 1 Non non JJ cord-010092-uftc8inx 11299 2 - - JJ cord-010092-uftc8inx 11299 3 transfused transfuse VBN cord-010092-uftc8inx 11299 4 patients patient NNS cord-010092-uftc8inx 11299 5 were be VBD cord-010092-uftc8inx 11299 6 significantly significantly RB cord-010092-uftc8inx 11299 7 more more JJR cord-010092-uftc8inx 11299 8 than than IN cord-010092-uftc8inx 11299 9 transfused transfused JJ cord-010092-uftc8inx 11299 10 ones one NNS cord-010092-uftc8inx 11299 11 ( ( -LRB- cord-010092-uftc8inx 11299 12 P p NN cord-010092-uftc8inx 11299 13 < < XX cord-010092-uftc8inx 11299 14 0.05 0.05 CD cord-010092-uftc8inx 11299 15 ) ) -RRB- cord-010092-uftc8inx 11299 16 . . . cord-010092-uftc8inx 11300 1 Frequency frequency NN cord-010092-uftc8inx 11300 2 of of IN cord-010092-uftc8inx 11300 3 blood blood NN cord-010092-uftc8inx 11300 4 transfusion transfusion NN cord-010092-uftc8inx 11300 5 was be VBD cord-010092-uftc8inx 11300 6 more more JJR cord-010092-uftc8inx 11300 7 in in IN cord-010092-uftc8inx 11300 8 young young JJ cord-010092-uftc8inx 11300 9 patients patient NNS cord-010092-uftc8inx 11300 10 ( ( -LRB- cord-010092-uftc8inx 11300 11 4.9 4.9 CD cord-010092-uftc8inx 11300 12 % % NN cord-010092-uftc8inx 11300 13 ) ) -RRB- cord-010092-uftc8inx 11300 14 . . . cord-010092-uftc8inx 11301 1 Seven seven CD cord-010092-uftc8inx 11301 2 ( ( -LRB- cord-010092-uftc8inx 11301 3 22.6 22.6 CD cord-010092-uftc8inx 11301 4 % % NN cord-010092-uftc8inx 11301 5 ) ) -RRB- cord-010092-uftc8inx 11301 6 of of IN cord-010092-uftc8inx 11301 7 the the DT cord-010092-uftc8inx 11301 8 total total JJ cord-010092-uftc8inx 11301 9 31 31 CD cord-010092-uftc8inx 11301 10 stage stage NN cord-010092-uftc8inx 11301 11 IV IV NNP cord-010092-uftc8inx 11301 12 patients patient NNS cord-010092-uftc8inx 11301 13 received receive VBD cord-010092-uftc8inx 11301 14 blood blood NN cord-010092-uftc8inx 11301 15 transfusions transfusion NNS cord-010092-uftc8inx 11301 16 . . . cord-010092-uftc8inx 11302 1 Frequency frequency NN cord-010092-uftc8inx 11302 2 of of IN cord-010092-uftc8inx 11302 3 blood blood NN cord-010092-uftc8inx 11302 4 transfusion transfusion NN cord-010092-uftc8inx 11302 5 was be VBD cord-010092-uftc8inx 11302 6 more more JJR cord-010092-uftc8inx 11302 7 in in IN cord-010092-uftc8inx 11302 8 patients patient NNS cord-010092-uftc8inx 11302 9 undergoing undergo VBG cord-010092-uftc8inx 11302 10 surgery surgery NN cord-010092-uftc8inx 11302 11 after after IN cord-010092-uftc8inx 11302 12 chemotherapy chemotherapy NN cord-010092-uftc8inx 11302 13 ( ( -LRB- cord-010092-uftc8inx 11302 14 8.8 8.8 CD cord-010092-uftc8inx 11302 15 % % NN cord-010092-uftc8inx 11302 16 ) ) -RRB- cord-010092-uftc8inx 11302 17 . . . cord-010092-uftc8inx 11303 1 A a DT cord-010092-uftc8inx 11303 2 significant significant JJ cord-010092-uftc8inx 11303 3 loss loss NN cord-010092-uftc8inx 11303 4 of of IN cord-010092-uftc8inx 11303 5 time time NN cord-010092-uftc8inx 11303 6 and and CC cord-010092-uftc8inx 11303 7 loss loss NN cord-010092-uftc8inx 11303 8 of of IN cord-010092-uftc8inx 11303 9 revenue revenue NN cord-010092-uftc8inx 11303 10 was be VBD cord-010092-uftc8inx 11303 11 observed observe VBN cord-010092-uftc8inx 11303 12 . . . cord-010092-uftc8inx 11304 1 Summary Summary NNP cord-010092-uftc8inx 11304 2 / / SYM cord-010092-uftc8inx 11304 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 11304 4 : : : cord-010092-uftc8inx 11305 1 We -PRON- PRP cord-010092-uftc8inx 11305 2 conclude conclude VBP cord-010092-uftc8inx 11305 3 that that IN cord-010092-uftc8inx 11305 4 routine routine JJ cord-010092-uftc8inx 11305 5 compatibility compatibility NN cord-010092-uftc8inx 11305 6 test test NN cord-010092-uftc8inx 11305 7 is be VBZ cord-010092-uftc8inx 11305 8 not not RB cord-010092-uftc8inx 11305 9 justified justified JJ cord-010092-uftc8inx 11305 10 for for IN cord-010092-uftc8inx 11305 11 all all DT cord-010092-uftc8inx 11305 12 patients patient NNS cord-010092-uftc8inx 11305 13 undergoing undergo VBG cord-010092-uftc8inx 11305 14 breast breast NN cord-010092-uftc8inx 11305 15 surgery surgery NN cord-010092-uftc8inx 11305 16 . . . cord-010092-uftc8inx 11306 1 A a DT cord-010092-uftc8inx 11306 2 more more RBR cord-010092-uftc8inx 11306 3 targeted target VBN cord-010092-uftc8inx 11306 4 approach approach NN cord-010092-uftc8inx 11306 5 is be VBZ cord-010092-uftc8inx 11306 6 needed need VBN cord-010092-uftc8inx 11306 7 to to TO cord-010092-uftc8inx 11306 8 reduce reduce VB cord-010092-uftc8inx 11306 9 blood blood NN cord-010092-uftc8inx 11306 10 demand demand NN cord-010092-uftc8inx 11306 11 and and CC cord-010092-uftc8inx 11306 12 associated associate VBN cord-010092-uftc8inx 11306 13 cost cost NN cord-010092-uftc8inx 11306 14 to to IN cord-010092-uftc8inx 11306 15 patient patient NN cord-010092-uftc8inx 11306 16 and and CC cord-010092-uftc8inx 11306 17 blood blood NN cord-010092-uftc8inx 11306 18 transfusion transfusion NN cord-010092-uftc8inx 11306 19 services service NNS cord-010092-uftc8inx 11306 20 . . . cord-010092-uftc8inx 11307 1 Background background NN cord-010092-uftc8inx 11307 2 : : : cord-010092-uftc8inx 11308 1 Blood blood NN cord-010092-uftc8inx 11308 2 transfusion transfusion NN cord-010092-uftc8inx 11308 3 guidelines guideline NNS cord-010092-uftc8inx 11308 4 are be VBP cord-010092-uftc8inx 11308 5 not not RB cord-010092-uftc8inx 11308 6 only only RB cord-010092-uftc8inx 11308 7 essential essential JJ cord-010092-uftc8inx 11308 8 for for IN cord-010092-uftc8inx 11308 9 the the DT cord-010092-uftc8inx 11308 10 optimal optimal JJ cord-010092-uftc8inx 11308 11 use use NN cord-010092-uftc8inx 11308 12 of of IN cord-010092-uftc8inx 11308 13 blood blood NN cord-010092-uftc8inx 11308 14 products product NNS cord-010092-uftc8inx 11308 15 , , , cord-010092-uftc8inx 11308 16 but but CC cord-010092-uftc8inx 11308 17 also also RB cord-010092-uftc8inx 11308 18 help help VB cord-010092-uftc8inx 11308 19 reduce reduce VB cord-010092-uftc8inx 11308 20 transfusion transfusion NN cord-010092-uftc8inx 11308 21 - - HYPH cord-010092-uftc8inx 11308 22 related relate VBN cord-010092-uftc8inx 11308 23 adverse adverse JJ cord-010092-uftc8inx 11308 24 reactions reaction NNS cord-010092-uftc8inx 11308 25 and and CC cord-010092-uftc8inx 11308 26 improve improve VB cord-010092-uftc8inx 11308 27 patient patient JJ cord-010092-uftc8inx 11308 28 outcomes outcome NNS cord-010092-uftc8inx 11308 29 . . . cord-010092-uftc8inx 11309 1 The the DT cord-010092-uftc8inx 11309 2 Korean korean JJ cord-010092-uftc8inx 11309 3 national national JJ cord-010092-uftc8inx 11309 4 transfusion transfusion NN cord-010092-uftc8inx 11309 5 guidelines guideline NNS cord-010092-uftc8inx 11309 6 were be VBD cord-010092-uftc8inx 11309 7 developed develop VBN cord-010092-uftc8inx 11309 8 in in IN cord-010092-uftc8inx 11309 9 2009 2009 CD cord-010092-uftc8inx 11309 10 and and CC cord-010092-uftc8inx 11309 11 fully fully RB cord-010092-uftc8inx 11309 12 revised revise VBN cord-010092-uftc8inx 11309 13 in in IN cord-010092-uftc8inx 11309 14 2016 2016 CD cord-010092-uftc8inx 11309 15 by by IN cord-010092-uftc8inx 11309 16 the the DT cord-010092-uftc8inx 11309 17 Korean Korean NNP cord-010092-uftc8inx 11309 18 Centers Centers NNPS cord-010092-uftc8inx 11309 19 for for IN cord-010092-uftc8inx 11309 20 Disease Disease NNP cord-010092-uftc8inx 11309 21 Control Control NNP cord-010092-uftc8inx 11309 22 and and CC cord-010092-uftc8inx 11309 23 Prevention Prevention NNP cord-010092-uftc8inx 11309 24 and and CC cord-010092-uftc8inx 11309 25 the the DT cord-010092-uftc8inx 11309 26 Korean Korean NNP cord-010092-uftc8inx 11309 27 Society Society NNP cord-010092-uftc8inx 11309 28 of of IN cord-010092-uftc8inx 11309 29 Blood Blood NNP cord-010092-uftc8inx 11309 30 Transfusion Transfusion NNP cord-010092-uftc8inx 11309 31 . . . cord-010092-uftc8inx 11310 1 In in IN cord-010092-uftc8inx 11310 2 our -PRON- PRP$ cord-010092-uftc8inx 11310 3 hospital hospital NN cord-010092-uftc8inx 11310 4 , , , cord-010092-uftc8inx 11310 5 which which WDT cord-010092-uftc8inx 11310 6 is be VBZ cord-010092-uftc8inx 11310 7 a a DT cord-010092-uftc8inx 11310 8 700-bed 700-bed CD cord-010092-uftc8inx 11310 9 university university NN cord-010092-uftc8inx 11310 10 hospital hospital NN cord-010092-uftc8inx 11310 11 , , , cord-010092-uftc8inx 11310 12 a a DT cord-010092-uftc8inx 11310 13 transfusion transfusion NN cord-010092-uftc8inx 11310 14 - - HYPH cord-010092-uftc8inx 11310 15 indication indication NN cord-010092-uftc8inx 11310 16 data data NN cord-010092-uftc8inx 11310 17 - - HYPH cord-010092-uftc8inx 11310 18 entry entry NN cord-010092-uftc8inx 11310 19 program program NN cord-010092-uftc8inx 11310 20 based base VBN cord-010092-uftc8inx 11310 21 on on IN cord-010092-uftc8inx 11310 22 the the DT cord-010092-uftc8inx 11310 23 national national JJ cord-010092-uftc8inx 11310 24 transfusion transfusion NN cord-010092-uftc8inx 11310 25 guidelines guideline NNS cord-010092-uftc8inx 11310 26 was be VBD cord-010092-uftc8inx 11310 27 developed develop VBN cord-010092-uftc8inx 11310 28 in in IN cord-010092-uftc8inx 11310 29 2016 2016 CD cord-010092-uftc8inx 11310 30 . . . cord-010092-uftc8inx 11311 1 It -PRON- PRP cord-010092-uftc8inx 11311 2 was be VBD cord-010092-uftc8inx 11311 3 applied apply VBN cord-010092-uftc8inx 11311 4 to to IN cord-010092-uftc8inx 11311 5 the the DT cord-010092-uftc8inx 11311 6 electronic electronic JJ cord-010092-uftc8inx 11311 7 medical medical JJ cord-010092-uftc8inx 11311 8 record record NN cord-010092-uftc8inx 11311 9 system system NN cord-010092-uftc8inx 11311 10 and and CC cord-010092-uftc8inx 11311 11 all all DT cord-010092-uftc8inx 11311 12 transfusion transfusion NN cord-010092-uftc8inx 11311 13 orders order NNS cord-010092-uftc8inx 11311 14 , , , cord-010092-uftc8inx 11311 15 except except IN cord-010092-uftc8inx 11311 16 emergencies emergency NNS cord-010092-uftc8inx 11311 17 , , , cord-010092-uftc8inx 11311 18 have have VBP cord-010092-uftc8inx 11311 19 been be VBN cord-010092-uftc8inx 11311 20 performed perform VBN cord-010092-uftc8inx 11311 21 through through IN cord-010092-uftc8inx 11311 22 this this DT cord-010092-uftc8inx 11311 23 program program NN cord-010092-uftc8inx 11311 24 since since IN cord-010092-uftc8inx 11311 25 then then RB cord-010092-uftc8inx 11311 26 . . . cord-010092-uftc8inx 11312 1 Aims aim VBZ cord-010092-uftc8inx 11312 2 : : : cord-010092-uftc8inx 11312 3 We -PRON- PRP cord-010092-uftc8inx 11312 4 planned plan VBD cord-010092-uftc8inx 11312 5 to to TO cord-010092-uftc8inx 11312 6 record record VB cord-010092-uftc8inx 11312 7 and and CC cord-010092-uftc8inx 11312 8 analyze analyze VB cord-010092-uftc8inx 11312 9 the the DT cord-010092-uftc8inx 11312 10 reasons reason NNS cord-010092-uftc8inx 11312 11 for for IN cord-010092-uftc8inx 11312 12 transfusion transfusion NN cord-010092-uftc8inx 11312 13 in in IN cord-010092-uftc8inx 11312 14 order order NN cord-010092-uftc8inx 11312 15 to to TO cord-010092-uftc8inx 11312 16 monitor monitor VB cord-010092-uftc8inx 11312 17 blood blood NN cord-010092-uftc8inx 11312 18 product product NN cord-010092-uftc8inx 11312 19 usage usage NN cord-010092-uftc8inx 11312 20 and and CC cord-010092-uftc8inx 11312 21 provide provide VB cord-010092-uftc8inx 11312 22 feedback feedback NN cord-010092-uftc8inx 11312 23 to to IN cord-010092-uftc8inx 11312 24 clinicians clinician NNS cord-010092-uftc8inx 11312 25 . . . cord-010092-uftc8inx 11313 1 Furthermore furthermore RB cord-010092-uftc8inx 11313 2 , , , cord-010092-uftc8inx 11313 3 we -PRON- PRP cord-010092-uftc8inx 11313 4 intended intend VBD cord-010092-uftc8inx 11313 5 to to TO cord-010092-uftc8inx 11313 6 contribute contribute VB cord-010092-uftc8inx 11313 7 to to IN cord-010092-uftc8inx 11313 8 patient patient JJ cord-010092-uftc8inx 11313 9 safety safety NN cord-010092-uftc8inx 11313 10 through through IN cord-010092-uftc8inx 11313 11 the the DT cord-010092-uftc8inx 11313 12 appropriate appropriate JJ cord-010092-uftc8inx 11313 13 use use NN cord-010092-uftc8inx 11313 14 of of IN cord-010092-uftc8inx 11313 15 blood blood NN cord-010092-uftc8inx 11313 16 products product NNS cord-010092-uftc8inx 11313 17 . . . cord-010092-uftc8inx 11314 1 Methods method NNS cord-010092-uftc8inx 11314 2 : : : cord-010092-uftc8inx 11315 1 We -PRON- PRP cord-010092-uftc8inx 11315 2 classified classify VBD cord-010092-uftc8inx 11315 3 transfusion transfusion NN cord-010092-uftc8inx 11315 4 - - HYPH cord-010092-uftc8inx 11315 5 indications indication NNS cord-010092-uftc8inx 11315 6 by by IN cord-010092-uftc8inx 11315 7 the the DT cord-010092-uftc8inx 11315 8 blood blood NN cord-010092-uftc8inx 11315 9 product product NN cord-010092-uftc8inx 11315 10 requested request VBD cord-010092-uftc8inx 11315 11 and and CC cord-010092-uftc8inx 11315 12 created create VBD cord-010092-uftc8inx 11315 13 a a DT cord-010092-uftc8inx 11315 14 pop pop VB cord-010092-uftc8inx 11315 15 - - HYPH cord-010092-uftc8inx 11315 16 up up RP cord-010092-uftc8inx 11315 17 window window NN cord-010092-uftc8inx 11315 18 listing list VBG cord-010092-uftc8inx 11315 19 these these DT cord-010092-uftc8inx 11315 20 indications indication NNS cord-010092-uftc8inx 11315 21 , , , cord-010092-uftc8inx 11315 22 which which WDT cord-010092-uftc8inx 11315 23 would would MD cord-010092-uftc8inx 11315 24 appear appear VB cord-010092-uftc8inx 11315 25 at at IN cord-010092-uftc8inx 11315 26 each each DT cord-010092-uftc8inx 11315 27 regular regular JJ cord-010092-uftc8inx 11315 28 transfusion transfusion NN cord-010092-uftc8inx 11315 29 order order NN cord-010092-uftc8inx 11315 30 . . . cord-010092-uftc8inx 11316 1 Indications indication NNS cord-010092-uftc8inx 11316 2 for for IN cord-010092-uftc8inx 11316 3 transfusion transfusion NN cord-010092-uftc8inx 11316 4 with with IN cord-010092-uftc8inx 11316 5 each each DT cord-010092-uftc8inx 11316 6 blood blood NN cord-010092-uftc8inx 11316 7 product product NN cord-010092-uftc8inx 11316 8 were be VBD cord-010092-uftc8inx 11316 9 as as IN cord-010092-uftc8inx 11316 10 follows follow VBZ cord-010092-uftc8inx 11316 11 : : : cord-010092-uftc8inx 11317 1 Red red JJ cord-010092-uftc8inx 11317 2 blood blood NN cord-010092-uftc8inx 11317 3 cells cell NNS cord-010092-uftc8inx 11317 4 ( ( -LRB- cord-010092-uftc8inx 11317 5 RBCs)acute rbcs)acute NN cord-010092-uftc8inx 11317 6 blood blood NN cord-010092-uftc8inx 11317 7 loss loss NN cord-010092-uftc8inx 11317 8 , , , cord-010092-uftc8inx 11317 9 chronic chronic JJ cord-010092-uftc8inx 11317 10 disease disease NN cord-010092-uftc8inx 11317 11 ( ( -LRB- cord-010092-uftc8inx 11317 12 sub sub NN cord-010092-uftc8inx 11317 13 - - HYPH cord-010092-uftc8inx 11317 14 classified classify VBN cord-010092-uftc8inx 11317 15 as as IN cord-010092-uftc8inx 11317 16 Hb Hb NNP cord-010092-uftc8inx 11317 17 ≤ ≤ NNP cord-010092-uftc8inx 11318 1 7 7 CD cord-010092-uftc8inx 11318 2 g g NN cord-010092-uftc8inx 11318 3 / / SYM cord-010092-uftc8inx 11318 4 dL dl NN cord-010092-uftc8inx 11318 5 , , , cord-010092-uftc8inx 11318 6 cardiovascular cardiovascular JJ cord-010092-uftc8inx 11318 7 disease disease NN cord-010092-uftc8inx 11318 8 , , , cord-010092-uftc8inx 11318 9 cerebrovascular cerebrovascular JJ cord-010092-uftc8inx 11318 10 disease disease NN cord-010092-uftc8inx 11318 11 , , , cord-010092-uftc8inx 11318 12 peripheral peripheral JJ cord-010092-uftc8inx 11318 13 vascular vascular JJ cord-010092-uftc8inx 11318 14 disease disease NN cord-010092-uftc8inx 11318 15 , , , cord-010092-uftc8inx 11318 16 respiratory respiratory JJ cord-010092-uftc8inx 11318 17 disease disease NN cord-010092-uftc8inx 11318 18 , , , cord-010092-uftc8inx 11318 19 age age NN cord-010092-uftc8inx 11318 20 ≥ ≥ CD cord-010092-uftc8inx 11318 21 65 65 CD cord-010092-uftc8inx 11318 22 years year NNS cord-010092-uftc8inx 11318 23 , , , cord-010092-uftc8inx 11318 24 age age NN cord-010092-uftc8inx 11318 25 ≤ ≤ NNS cord-010092-uftc8inx 11318 26 6 6 CD cord-010092-uftc8inx 11318 27 months month NNS cord-010092-uftc8inx 11318 28 , , , cord-010092-uftc8inx 11318 29 chemotherapy chemotherapy NN cord-010092-uftc8inx 11318 30 ) ) -RRB- cord-010092-uftc8inx 11318 31 , , , cord-010092-uftc8inx 11318 32 surgery/ surgery/ CD cord-010092-uftc8inx 11318 33 procedure procedure NN cord-010092-uftc8inx 11318 34 , , , cord-010092-uftc8inx 11318 35 transplantation transplantation NN cord-010092-uftc8inx 11318 36 and and CC cord-010092-uftc8inx 11318 37 ' ' `` cord-010092-uftc8inx 11318 38 other other JJ cord-010092-uftc8inx 11318 39 ' ' '' cord-010092-uftc8inx 11318 40 ; ; : cord-010092-uftc8inx 11318 41 Platelets platelet NNS cord-010092-uftc8inx 11318 42 ( ( -LRB- cord-010092-uftc8inx 11318 43 PLTs)present plts)present NN cord-010092-uftc8inx 11318 44 bleeding bleeding NN cord-010092-uftc8inx 11318 45 , , , cord-010092-uftc8inx 11318 46 bleeding bleed VBG cord-010092-uftc8inx 11318 47 prevention prevention NN cord-010092-uftc8inx 11318 48 ( ( -LRB- cord-010092-uftc8inx 11318 49 sub sub NN cord-010092-uftc8inx 11318 50 - - HYPH cord-010092-uftc8inx 11318 51 classified classify VBN cord-010092-uftc8inx 11318 52 as as IN cord-010092-uftc8inx 11318 53 hematologic hematologic JJ cord-010092-uftc8inx 11318 54 disease disease NN cord-010092-uftc8inx 11318 55 , , , cord-010092-uftc8inx 11318 56 solid solid JJ cord-010092-uftc8inx 11318 57 tumor tumor NN cord-010092-uftc8inx 11318 58 , , , cord-010092-uftc8inx 11318 59 peripheral peripheral JJ cord-010092-uftc8inx 11318 60 blood blood NN cord-010092-uftc8inx 11318 61 stem stem NN cord-010092-uftc8inx 11318 62 cell cell NN cord-010092-uftc8inx 11318 63 transplantation transplantation NN cord-010092-uftc8inx 11318 64 , , , cord-010092-uftc8inx 11318 65 disseminated disseminate VBN cord-010092-uftc8inx 11318 66 intravascular intravascular JJ cord-010092-uftc8inx 11318 67 coagulopathy coagulopathy NN cord-010092-uftc8inx 11318 68 , , , cord-010092-uftc8inx 11318 69 infant infant NN cord-010092-uftc8inx 11318 70 ) ) -RRB- cord-010092-uftc8inx 11318 71 , , , cord-010092-uftc8inx 11318 72 surgery surgery NN cord-010092-uftc8inx 11318 73 / / SYM cord-010092-uftc8inx 11318 74 procedure procedure NN cord-010092-uftc8inx 11318 75 , , , cord-010092-uftc8inx 11318 76 massive massive JJ cord-010092-uftc8inx 11318 77 transfusion transfusion NN cord-010092-uftc8inx 11318 78 and and CC cord-010092-uftc8inx 11318 79 ' ' `` cord-010092-uftc8inx 11318 80 other other JJ cord-010092-uftc8inx 11318 81 ' ' '' cord-010092-uftc8inx 11318 82 ; ; : cord-010092-uftc8inx 11318 83 Fresh fresh JJ cord-010092-uftc8inx 11318 84 frozen frozen JJ cord-010092-uftc8inx 11318 85 plasma plasma NN cord-010092-uftc8inx 11318 86 ( ( -LRB- cord-010092-uftc8inx 11318 87 FFP)bleeding FFP)bleeding NNP cord-010092-uftc8inx 11318 88 in in IN cord-010092-uftc8inx 11318 89 coagulopathy coagulopathy NN cord-010092-uftc8inx 11318 90 , , , cord-010092-uftc8inx 11318 91 bleeding bleed VBG cord-010092-uftc8inx 11318 92 prevention prevention NN cord-010092-uftc8inx 11318 93 in in IN cord-010092-uftc8inx 11318 94 coagulopathy coagulopathy NN cord-010092-uftc8inx 11318 95 , , , cord-010092-uftc8inx 11318 96 massive massive JJ cord-010092-uftc8inx 11318 97 transfusion transfusion NN cord-010092-uftc8inx 11318 98 , , , cord-010092-uftc8inx 11318 99 plasma plasma NN cord-010092-uftc8inx 11318 100 exchange exchange NN cord-010092-uftc8inx 11318 101 and and CC cord-010092-uftc8inx 11318 102 ' ' `` cord-010092-uftc8inx 11318 103 other other JJ cord-010092-uftc8inx 11318 104 ' ' '' cord-010092-uftc8inx 11318 105 . . . cord-010092-uftc8inx 11319 1 Transfusion transfusion NN cord-010092-uftc8inx 11319 2 indications indication NNS cord-010092-uftc8inx 11319 3 entered enter VBD cord-010092-uftc8inx 11319 4 into into IN cord-010092-uftc8inx 11319 5 the the DT cord-010092-uftc8inx 11319 6 data data NN cord-010092-uftc8inx 11319 7 - - HYPH cord-010092-uftc8inx 11319 8 entry entry NN cord-010092-uftc8inx 11319 9 program program NN cord-010092-uftc8inx 11319 10 from from IN cord-010092-uftc8inx 11319 11 Sep Sep NNP cord-010092-uftc8inx 11319 12 2016 2016 CD cord-010092-uftc8inx 11319 13 to to IN cord-010092-uftc8inx 11319 14 Feb Feb NNP cord-010092-uftc8inx 11319 15 2018 2018 CD cord-010092-uftc8inx 11319 16 were be VBD cord-010092-uftc8inx 11319 17 analyzed analyze VBN cord-010092-uftc8inx 11319 18 . . . cord-010092-uftc8inx 11320 1 Results result NNS cord-010092-uftc8inx 11320 2 : : : cord-010092-uftc8inx 11321 1 The the DT cord-010092-uftc8inx 11321 2 number number NN cord-010092-uftc8inx 11321 3 of of IN cord-010092-uftc8inx 11321 4 transfusion transfusion NN cord-010092-uftc8inx 11321 5 - - HYPH cord-010092-uftc8inx 11321 6 indications indication NNS cord-010092-uftc8inx 11321 7 analyzed analyze VBN cord-010092-uftc8inx 11321 8 was be VBD cord-010092-uftc8inx 11321 9 16138 16138 CD cord-010092-uftc8inx 11321 10 for for IN cord-010092-uftc8inx 11321 11 RBCs rbc NNS cord-010092-uftc8inx 11321 12 , , , cord-010092-uftc8inx 11321 13 11158 11158 CD cord-010092-uftc8inx 11321 14 for for IN cord-010092-uftc8inx 11321 15 PLTs plt NNS cord-010092-uftc8inx 11321 16 and and CC cord-010092-uftc8inx 11321 17 6024 6024 CD cord-010092-uftc8inx 11321 18 for for IN cord-010092-uftc8inx 11321 19 FFPs ffp NNS cord-010092-uftc8inx 11321 20 . . . cord-010092-uftc8inx 11322 1 The the DT cord-010092-uftc8inx 11322 2 most most RBS cord-010092-uftc8inx 11322 3 common common JJ cord-010092-uftc8inx 11322 4 indications indication NNS cord-010092-uftc8inx 11322 5 for for IN cord-010092-uftc8inx 11322 6 transfusion transfusion NN cord-010092-uftc8inx 11322 7 were be VBD cord-010092-uftc8inx 11322 8 chronic chronic JJ cord-010092-uftc8inx 11322 9 disease disease NN cord-010092-uftc8inx 11322 10 for for IN cord-010092-uftc8inx 11322 11 RBCs rbc NNS cord-010092-uftc8inx 11322 12 ( ( -LRB- cord-010092-uftc8inx 11322 13 7977/16138 7977/16138 CD cord-010092-uftc8inx 11322 14 , , , cord-010092-uftc8inx 11322 15 49.4 49.4 CD cord-010092-uftc8inx 11322 16 % % NN cord-010092-uftc8inx 11322 17 ) ) -RRB- cord-010092-uftc8inx 11322 18 , , , cord-010092-uftc8inx 11322 19 bleeding bleed VBG cord-010092-uftc8inx 11322 20 prevention prevention NN cord-010092-uftc8inx 11322 21 for for IN cord-010092-uftc8inx 11322 22 PLTs plt NNS cord-010092-uftc8inx 11322 23 ( ( -LRB- cord-010092-uftc8inx 11322 24 5726/11158 5726/11158 CD cord-010092-uftc8inx 11322 25 , , , cord-010092-uftc8inx 11322 26 51.3 51.3 CD cord-010092-uftc8inx 11322 27 % % NN cord-010092-uftc8inx 11322 28 ) ) -RRB- cord-010092-uftc8inx 11322 29 and and CC cord-010092-uftc8inx 11322 30 ' ' `` cord-010092-uftc8inx 11322 31 other other JJ cord-010092-uftc8inx 11322 32 ' ' '' cord-010092-uftc8inx 11322 33 for for IN cord-010092-uftc8inx 11322 34 FFP FFP NNP cord-010092-uftc8inx 11322 35 ( ( -LRB- cord-010092-uftc8inx 11322 36 2180/6024 2180/6024 CD cord-010092-uftc8inx 11322 37 , , , cord-010092-uftc8inx 11322 38 36.2 36.2 CD cord-010092-uftc8inx 11322 39 % % NN cord-010092-uftc8inx 11322 40 ) ) -RRB- cord-010092-uftc8inx 11322 41 . . . cord-010092-uftc8inx 11322 42 ' ' '' cord-010092-uftc8inx 11323 1 Hb Hb NNP cord-010092-uftc8inx 11323 2 ≤ ≤ NNP cord-010092-uftc8inx 11323 3 7 7 CD cord-010092-uftc8inx 11323 4 g g NN cord-010092-uftc8inx 11323 5 / / SYM cord-010092-uftc8inx 11323 6 dL dl NN cord-010092-uftc8inx 11323 7 ' ' '' cord-010092-uftc8inx 11323 8 was be VBD cord-010092-uftc8inx 11323 9 the the DT cord-010092-uftc8inx 11323 10 most most RBS cord-010092-uftc8inx 11323 11 frequent frequent JJ cord-010092-uftc8inx 11323 12 sub sub NN cord-010092-uftc8inx 11323 13 - - JJ cord-010092-uftc8inx 11323 14 indication indication NN cord-010092-uftc8inx 11323 15 of of IN cord-010092-uftc8inx 11323 16 chronic chronic JJ cord-010092-uftc8inx 11323 17 disease disease NN cord-010092-uftc8inx 11323 18 ( ( -LRB- cord-010092-uftc8inx 11323 19 3570/7977 3570/7977 CD cord-010092-uftc8inx 11323 20 , , , cord-010092-uftc8inx 11323 21 44.8 44.8 CD cord-010092-uftc8inx 11323 22 % % NN cord-010092-uftc8inx 11323 23 ) ) -RRB- cord-010092-uftc8inx 11323 24 , , , cord-010092-uftc8inx 11323 25 and and CC cord-010092-uftc8inx 11323 26 hematologic hematologic JJ cord-010092-uftc8inx 11323 27 disease disease NN cord-010092-uftc8inx 11323 28 was be VBD cord-010092-uftc8inx 11323 29 the the DT cord-010092-uftc8inx 11323 30 most most RBS cord-010092-uftc8inx 11323 31 frequent frequent JJ cord-010092-uftc8inx 11323 32 sub sub NN cord-010092-uftc8inx 11323 33 - - JJ cord-010092-uftc8inx 11323 34 indication indication NN cord-010092-uftc8inx 11323 35 of of IN cord-010092-uftc8inx 11323 36 bleeding bleed VBG cord-010092-uftc8inx 11323 37 prevention prevention NN cord-010092-uftc8inx 11323 38 ( ( -LRB- cord-010092-uftc8inx 11323 39 3432/ 3432/ CD cord-010092-uftc8inx 11323 40 5726 5726 CD cord-010092-uftc8inx 11323 41 , , , cord-010092-uftc8inx 11323 42 59.3 59.3 CD cord-010092-uftc8inx 11323 43 % % NN cord-010092-uftc8inx 11323 44 ) ) -RRB- cord-010092-uftc8inx 11323 45 . . . cord-010092-uftc8inx 11324 1 Many many JJ cord-010092-uftc8inx 11324 2 clinicians clinician NNS cord-010092-uftc8inx 11324 3 entered enter VBD cord-010092-uftc8inx 11324 4 transfusion transfusion NN cord-010092-uftc8inx 11324 5 indication indication NN cord-010092-uftc8inx 11324 6 as as IN cord-010092-uftc8inx 11324 7 ' ' `` cord-010092-uftc8inx 11324 8 other other JJ cord-010092-uftc8inx 11324 9 ' ' '' cord-010092-uftc8inx 11324 10 : : : cord-010092-uftc8inx 11324 11 RBCs rbc NNS cord-010092-uftc8inx 11324 12 ( ( -LRB- cord-010092-uftc8inx 11324 13 2866/ 2866/ CD cord-010092-uftc8inx 11324 14 16138 16138 CD cord-010092-uftc8inx 11324 15 , , , cord-010092-uftc8inx 11324 16 17.5 17.5 CD cord-010092-uftc8inx 11324 17 % % NN cord-010092-uftc8inx 11324 18 ) ) -RRB- cord-010092-uftc8inx 11324 19 , , , cord-010092-uftc8inx 11324 20 PLTs PLTs NNP cord-010092-uftc8inx 11324 21 ( ( -LRB- cord-010092-uftc8inx 11324 22 856/11158 856/11158 CD cord-010092-uftc8inx 11324 23 , , , cord-010092-uftc8inx 11324 24 7.7 7.7 CD cord-010092-uftc8inx 11324 25 % % NN cord-010092-uftc8inx 11324 26 ) ) -RRB- cord-010092-uftc8inx 11324 27 and and CC cord-010092-uftc8inx 11324 28 FFP FFP NNP cord-010092-uftc8inx 11324 29 ( ( -LRB- cord-010092-uftc8inx 11324 30 2180/6024 2180/6024 CD cord-010092-uftc8inx 11324 31 , , , cord-010092-uftc8inx 11324 32 36.2 36.2 CD cord-010092-uftc8inx 11324 33 % % NN cord-010092-uftc8inx 11324 34 ) ) -RRB- cord-010092-uftc8inx 11324 35 . . . cord-010092-uftc8inx 11325 1 However however RB cord-010092-uftc8inx 11325 2 , , , cord-010092-uftc8inx 11325 3 the the DT cord-010092-uftc8inx 11325 4 free free JJ cord-010092-uftc8inx 11325 5 - - HYPH cord-010092-uftc8inx 11325 6 text text NN cord-010092-uftc8inx 11325 7 supplied supply VBN cord-010092-uftc8inx 11325 8 by by IN cord-010092-uftc8inx 11325 9 the the DT cord-010092-uftc8inx 11325 10 clinician clinician NN cord-010092-uftc8inx 11325 11 when when WRB cord-010092-uftc8inx 11325 12 ' ' `` cord-010092-uftc8inx 11325 13 other other JJ cord-010092-uftc8inx 11325 14 ' ' '' cord-010092-uftc8inx 11325 15 was be VBD cord-010092-uftc8inx 11325 16 selected select VBN cord-010092-uftc8inx 11325 17 , , , cord-010092-uftc8inx 11325 18 often often RB cord-010092-uftc8inx 11325 19 corresponded correspond VBD cord-010092-uftc8inx 11325 20 to to IN cord-010092-uftc8inx 11325 21 an an DT cord-010092-uftc8inx 11325 22 indication indication NN cord-010092-uftc8inx 11325 23 already already RB cord-010092-uftc8inx 11325 24 categorized categorize VBN cord-010092-uftc8inx 11325 25 in in IN cord-010092-uftc8inx 11325 26 the the DT cord-010092-uftc8inx 11325 27 transfusion transfusion NN cord-010092-uftc8inx 11325 28 - - HYPH cord-010092-uftc8inx 11325 29 indication indication NN cord-010092-uftc8inx 11325 30 data data NN cord-010092-uftc8inx 11325 31 - - HYPH cord-010092-uftc8inx 11325 32 entry entry NN cord-010092-uftc8inx 11325 33 program program NN cord-010092-uftc8inx 11325 34 ; ; : cord-010092-uftc8inx 11325 35 82.9 82.9 CD cord-010092-uftc8inx 11325 36 % % NN cord-010092-uftc8inx 11325 37 of of IN cord-010092-uftc8inx 11325 38 RBCs rbc NNS cord-010092-uftc8inx 11325 39 and and CC cord-010092-uftc8inx 11325 40 54 54 CD cord-010092-uftc8inx 11325 41 % % NN cord-010092-uftc8inx 11325 42 of of IN cord-010092-uftc8inx 11325 43 PLTs plt NNS cord-010092-uftc8inx 11325 44 . . . cord-010092-uftc8inx 11326 1 Of of IN cord-010092-uftc8inx 11326 2 the the DT cord-010092-uftc8inx 11326 3 indications indication NNS cord-010092-uftc8inx 11326 4 entered enter VBD cord-010092-uftc8inx 11326 5 as as IN cord-010092-uftc8inx 11326 6 ' ' `` cord-010092-uftc8inx 11326 7 other other JJ cord-010092-uftc8inx 11326 8 ' ' '' cord-010092-uftc8inx 11326 9 in in IN cord-010092-uftc8inx 11326 10 FFP FFP NNP cord-010092-uftc8inx 11326 11 , , , cord-010092-uftc8inx 11326 12 80.3 80.3 CD cord-010092-uftc8inx 11326 13 % % NN cord-010092-uftc8inx 11326 14 were be VBD cord-010092-uftc8inx 11326 15 surgery surgery NN cord-010092-uftc8inx 11326 16 / / SYM cord-010092-uftc8inx 11326 17 procedure procedure NN cord-010092-uftc8inx 11326 18 - - HYPH cord-010092-uftc8inx 11326 19 related relate VBN cord-010092-uftc8inx 11326 20 . . . cord-010092-uftc8inx 11327 1 Summary Summary NNP cord-010092-uftc8inx 11327 2 / / SYM cord-010092-uftc8inx 11327 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 11327 4 : : : cord-010092-uftc8inx 11328 1 In in IN cord-010092-uftc8inx 11328 2 our -PRON- PRP$ cord-010092-uftc8inx 11328 3 hospital hospital NN cord-010092-uftc8inx 11328 4 , , , cord-010092-uftc8inx 11328 5 the the DT cord-010092-uftc8inx 11328 6 release release NN cord-010092-uftc8inx 11328 7 of of IN cord-010092-uftc8inx 11328 8 blood blood NN cord-010092-uftc8inx 11328 9 products product NNS cord-010092-uftc8inx 11328 10 has have VBZ cord-010092-uftc8inx 11328 11 been be VBN cord-010092-uftc8inx 11328 12 dependent dependent JJ cord-010092-uftc8inx 11328 13 on on IN cord-010092-uftc8inx 11328 14 the the DT cord-010092-uftc8inx 11328 15 data data NN cord-010092-uftc8inx 11328 16 - - HYPH cord-010092-uftc8inx 11328 17 entry entry NN cord-010092-uftc8inx 11328 18 of of IN cord-010092-uftc8inx 11328 19 transfusion transfusion NN cord-010092-uftc8inx 11328 20 indications indication NNS cord-010092-uftc8inx 11328 21 ( ( -LRB- cord-010092-uftc8inx 11328 22 except except IN cord-010092-uftc8inx 11328 23 in in IN cord-010092-uftc8inx 11328 24 emergencies emergency NNS cord-010092-uftc8inx 11328 25 ) ) -RRB- cord-010092-uftc8inx 11328 26 since since IN cord-010092-uftc8inx 11328 27 Sep Sep NNP cord-010092-uftc8inx 11328 28 2016 2016 CD cord-010092-uftc8inx 11328 29 . . . cord-010092-uftc8inx 11329 1 Transfusions transfusion NNS cord-010092-uftc8inx 11329 2 of of IN cord-010092-uftc8inx 11329 3 RBCs rbc NNS cord-010092-uftc8inx 11329 4 and and CC cord-010092-uftc8inx 11329 5 PLTs plt NNS cord-010092-uftc8inx 11329 6 were be VBD cord-010092-uftc8inx 11329 7 most most RBS cord-010092-uftc8inx 11329 8 common common JJ cord-010092-uftc8inx 11329 9 for for IN cord-010092-uftc8inx 11329 10 chronic chronic JJ cord-010092-uftc8inx 11329 11 disease disease NN cord-010092-uftc8inx 11329 12 and and CC cord-010092-uftc8inx 11329 13 bleeding bleeding NN cord-010092-uftc8inx 11329 14 prevention prevention NN cord-010092-uftc8inx 11329 15 , , , cord-010092-uftc8inx 11329 16 respectively respectively RB cord-010092-uftc8inx 11329 17 , , , cord-010092-uftc8inx 11329 18 but but CC cord-010092-uftc8inx 11329 19 many many JJ cord-010092-uftc8inx 11329 20 cases case NNS cord-010092-uftc8inx 11329 21 entered enter VBD cord-010092-uftc8inx 11329 22 as as IN cord-010092-uftc8inx 11329 23 ' ' `` cord-010092-uftc8inx 11329 24 other other JJ cord-010092-uftc8inx 11329 25 ' ' '' cord-010092-uftc8inx 11329 26 could could MD cord-010092-uftc8inx 11329 27 have have VB cord-010092-uftc8inx 11329 28 been be VBN cord-010092-uftc8inx 11329 29 categorized categorize VBN cord-010092-uftc8inx 11329 30 as as IN cord-010092-uftc8inx 11329 31 existing exist VBG cord-010092-uftc8inx 11329 32 indications indication NNS cord-010092-uftc8inx 11329 33 in in IN cord-010092-uftc8inx 11329 34 our -PRON- PRP$ cord-010092-uftc8inx 11329 35 data data NN cord-010092-uftc8inx 11329 36 - - HYPH cord-010092-uftc8inx 11329 37 entry entry NN cord-010092-uftc8inx 11329 38 program program NN cord-010092-uftc8inx 11329 39 . . . cord-010092-uftc8inx 11330 1 Therefore therefore RB cord-010092-uftc8inx 11330 2 , , , cord-010092-uftc8inx 11330 3 we -PRON- PRP cord-010092-uftc8inx 11330 4 conclude conclude VBP cord-010092-uftc8inx 11330 5 that that IN cord-010092-uftc8inx 11330 6 additional additional JJ cord-010092-uftc8inx 11330 7 training training NN cord-010092-uftc8inx 11330 8 is be VBZ cord-010092-uftc8inx 11330 9 needed need VBN cord-010092-uftc8inx 11330 10 for for IN cord-010092-uftc8inx 11330 11 clinicians clinician NNS cord-010092-uftc8inx 11330 12 regarding regard VBG cord-010092-uftc8inx 11330 13 the the DT cord-010092-uftc8inx 11330 14 determination determination NN cord-010092-uftc8inx 11330 15 of of IN cord-010092-uftc8inx 11330 16 transfusion transfusion NN cord-010092-uftc8inx 11330 17 - - HYPH cord-010092-uftc8inx 11330 18 indications indication NNS cord-010092-uftc8inx 11330 19 and and CC cord-010092-uftc8inx 11330 20 correct correct JJ cord-010092-uftc8inx 11330 21 use use NN cord-010092-uftc8inx 11330 22 of of IN cord-010092-uftc8inx 11330 23 the the DT cord-010092-uftc8inx 11330 24 transfusion transfusion NN cord-010092-uftc8inx 11330 25 - - HYPH cord-010092-uftc8inx 11330 26 indication indication NN cord-010092-uftc8inx 11330 27 dataentry dataentry NN cord-010092-uftc8inx 11330 28 program program NN cord-010092-uftc8inx 11330 29 , , , cord-010092-uftc8inx 11330 30 in in IN cord-010092-uftc8inx 11330 31 order order NN cord-010092-uftc8inx 11330 32 to to TO cord-010092-uftc8inx 11330 33 use use VB cord-010092-uftc8inx 11330 34 blood blood NN cord-010092-uftc8inx 11330 35 products product NNS cord-010092-uftc8inx 11330 36 more more RBR cord-010092-uftc8inx 11330 37 appropriately appropriately RB cord-010092-uftc8inx 11330 38 . . . cord-010092-uftc8inx 11331 1 Methods method NNS cord-010092-uftc8inx 11331 2 : : : cord-010092-uftc8inx 11332 1 This this DT cord-010092-uftc8inx 11332 2 was be VBD cord-010092-uftc8inx 11332 3 a a DT cord-010092-uftc8inx 11332 4 prospective prospective JJ cord-010092-uftc8inx 11332 5 cohort cohort NN cord-010092-uftc8inx 11332 6 designed design VBN cord-010092-uftc8inx 11332 7 study study NN cord-010092-uftc8inx 11332 8 . . . cord-010092-uftc8inx 11333 1 Subjects subject NNS cord-010092-uftc8inx 11333 2 were be VBD cord-010092-uftc8inx 11333 3 children child NNS cord-010092-uftc8inx 11333 4 aged age VBN cord-010092-uftc8inx 11333 5 1 1 CD cord-010092-uftc8inx 11333 6 - - SYM cord-010092-uftc8inx 11333 7 18 18 CD cord-010092-uftc8inx 11333 8 years year NNS cord-010092-uftc8inx 11333 9 with with IN cord-010092-uftc8inx 11333 10 indication indication NN cord-010092-uftc8inx 11333 11 of of IN cord-010092-uftc8inx 11333 12 platelet platelet NN cord-010092-uftc8inx 11333 13 transfusions transfusion NNS cord-010092-uftc8inx 11333 14 in in IN cord-010092-uftc8inx 11333 15 Sardjito Sardjito NNP cord-010092-uftc8inx 11333 16 Hospital Hospital NNP cord-010092-uftc8inx 11333 17 Yogyakarta Yogyakarta NNP cord-010092-uftc8inx 11333 18 Indonesia Indonesia NNP cord-010092-uftc8inx 11333 19 . . . cord-010092-uftc8inx 11334 1 The the DT cord-010092-uftc8inx 11334 2 patient patient NN cord-010092-uftc8inx 11334 3 samples sample NNS cord-010092-uftc8inx 11334 4 were be VBD cord-010092-uftc8inx 11334 5 collected collect VBN cord-010092-uftc8inx 11334 6 before before RB cord-010092-uftc8inx 11334 7 and and CC cord-010092-uftc8inx 11334 8 1 1 CD cord-010092-uftc8inx 11334 9 h h NN cord-010092-uftc8inx 11334 10 post post NN cord-010092-uftc8inx 11334 11 - - NN cord-010092-uftc8inx 11334 12 transfusion transfusion NN cord-010092-uftc8inx 11334 13 , , , cord-010092-uftc8inx 11334 14 the the DT cord-010092-uftc8inx 11334 15 expression expression NN cord-010092-uftc8inx 11334 16 of of IN cord-010092-uftc8inx 11334 17 CD62P cd62p NN cord-010092-uftc8inx 11334 18 on on IN cord-010092-uftc8inx 11334 19 platelet platelet NN cord-010092-uftc8inx 11334 20 was be VBD cord-010092-uftc8inx 11334 21 determined determine VBN cord-010092-uftc8inx 11334 22 by by IN cord-010092-uftc8inx 11334 23 flow flow NN cord-010092-uftc8inx 11334 24 cytometry cytometry NN cord-010092-uftc8inx 11334 25 method method NN cord-010092-uftc8inx 11334 26 . . . cord-010092-uftc8inx 11335 1 Results result NNS cord-010092-uftc8inx 11335 2 : : : cord-010092-uftc8inx 11336 1 There there EX cord-010092-uftc8inx 11336 2 were be VBD cord-010092-uftc8inx 11336 3 102 102 CD cord-010092-uftc8inx 11336 4 subjects subject NNS cord-010092-uftc8inx 11336 5 who who WP cord-010092-uftc8inx 11336 6 were be VBD cord-010092-uftc8inx 11336 7 divided divide VBN cord-010092-uftc8inx 11336 8 into into IN cord-010092-uftc8inx 11336 9 two two CD cord-010092-uftc8inx 11336 10 groups group NNS cord-010092-uftc8inx 11336 11 . . . cord-010092-uftc8inx 11337 1 Fifty fifty CD cord-010092-uftc8inx 11337 2 - - HYPH cord-010092-uftc8inx 11337 3 one one CD cord-010092-uftc8inx 11337 4 subjects subject NNS cord-010092-uftc8inx 11337 5 received receive VBD cord-010092-uftc8inx 11337 6 non non JJ cord-010092-uftc8inx 11337 7 - - JJ cord-010092-uftc8inx 11337 8 leukodepleted leukodepleted JJ cord-010092-uftc8inx 11337 9 PCs pc NNS cord-010092-uftc8inx 11337 10 and and CC cord-010092-uftc8inx 11337 11 the the DT cord-010092-uftc8inx 11337 12 other other JJ cord-010092-uftc8inx 11337 13 fifty fifty CD cord-010092-uftc8inx 11337 14 - - HYPH cord-010092-uftc8inx 11337 15 one one CD cord-010092-uftc8inx 11337 16 transfused transfuse VBN cord-010092-uftc8inx 11337 17 by by IN cord-010092-uftc8inx 11337 18 pre pre JJ cord-010092-uftc8inx 11337 19 - - JJ cord-010092-uftc8inx 11337 20 storage storage JJ cord-010092-uftc8inx 11337 21 leukodepleted leukodepleted JJ cord-010092-uftc8inx 11337 22 PCs pc NNS cord-010092-uftc8inx 11337 23 . . . cord-010092-uftc8inx 11338 1 The the DT cord-010092-uftc8inx 11338 2 mean mean NN cord-010092-uftc8inx 11338 3 of of IN cord-010092-uftc8inx 11338 4 pre pre JJ cord-010092-uftc8inx 11338 5 - - JJ cord-010092-uftc8inx 11338 6 transfusion transfusion JJ cord-010092-uftc8inx 11338 7 platelet platelet NN cord-010092-uftc8inx 11338 8 CD62P cd62p NN cord-010092-uftc8inx 11338 9 for for IN cord-010092-uftc8inx 11338 10 nonleukodepleted nonleukodepleted JJ cord-010092-uftc8inx 11338 11 and and CC cord-010092-uftc8inx 11338 12 leukodepleted leukodepleted JJ cord-010092-uftc8inx 11338 13 groups group NNS cord-010092-uftc8inx 11338 14 were be VBD cord-010092-uftc8inx 11338 15 26.2 26.2 CD cord-010092-uftc8inx 11338 16 % % NN cord-010092-uftc8inx 11338 17 and and CC cord-010092-uftc8inx 11338 18 27.7 27.7 CD cord-010092-uftc8inx 11338 19 % % NN cord-010092-uftc8inx 11338 20 , , , cord-010092-uftc8inx 11338 21 and and CC cord-010092-uftc8inx 11338 22 the the DT cord-010092-uftc8inx 11338 23 mean mean JJ cord-010092-uftc8inx 11338 24 increase increase NN cord-010092-uftc8inx 11338 25 of of IN cord-010092-uftc8inx 11338 26 post post JJ cord-010092-uftc8inx 11338 27 - - JJ cord-010092-uftc8inx 11338 28 transfusion transfusion JJ cord-010092-uftc8inx 11338 29 platelet platelet NN cord-010092-uftc8inx 11338 30 CD62P cd62p NN cord-010092-uftc8inx 11338 31 for for IN cord-010092-uftc8inx 11338 32 non non JJ cord-010092-uftc8inx 11338 33 - - JJ cord-010092-uftc8inx 11338 34 leukodepleted leukodepleted JJ cord-010092-uftc8inx 11338 35 was be VBD cord-010092-uftc8inx 11338 36 10.1 10.1 CD cord-010092-uftc8inx 11338 37 % % NN cord-010092-uftc8inx 11338 38 and and CC cord-010092-uftc8inx 11338 39 the the DT cord-010092-uftc8inx 11338 40 mean mean JJ cord-010092-uftc8inx 11338 41 decrease decrease NN cord-010092-uftc8inx 11338 42 of of IN cord-010092-uftc8inx 11338 43 leukodepleted leukodeplete VBN cord-010092-uftc8inx 11338 44 groups group NNS cord-010092-uftc8inx 11338 45 was be VBD cord-010092-uftc8inx 11338 46 3.3 3.3 CD cord-010092-uftc8inx 11338 47 % % NN cord-010092-uftc8inx 11338 48 . . . cord-010092-uftc8inx 11339 1 It -PRON- PRP cord-010092-uftc8inx 11339 2 was be VBD cord-010092-uftc8inx 11339 3 shown show VBN cord-010092-uftc8inx 11339 4 the the DT cord-010092-uftc8inx 11339 5 increase increase NN cord-010092-uftc8inx 11339 6 of of IN cord-010092-uftc8inx 11339 7 post post JJ cord-010092-uftc8inx 11339 8 - - JJ cord-010092-uftc8inx 11339 9 transfusion transfusion JJ cord-010092-uftc8inx 11339 10 platelet platelet NN cord-010092-uftc8inx 11339 11 CD62P cd62p NN cord-010092-uftc8inx 11339 12 for for IN cord-010092-uftc8inx 11339 13 non non JJ cord-010092-uftc8inx 11339 14 - - JJ cord-010092-uftc8inx 11339 15 leukodepleted leukodepleted JJ cord-010092-uftc8inx 11339 16 group group NN cord-010092-uftc8inx 11339 17 , , , cord-010092-uftc8inx 11339 18 and and CC cord-010092-uftc8inx 11339 19 it -PRON- PRP cord-010092-uftc8inx 11339 20 was be VBD cord-010092-uftc8inx 11339 21 significantly significantly RB cord-010092-uftc8inx 11339 22 ( ( -LRB- cord-010092-uftc8inx 11339 23 P p NN cord-010092-uftc8inx 11339 24 < < XX cord-010092-uftc8inx 11339 25 0.05 0.05 CD cord-010092-uftc8inx 11339 26 ) ) -RRB- cord-010092-uftc8inx 11339 27 higher high JJR cord-010092-uftc8inx 11339 28 than than IN cord-010092-uftc8inx 11339 29 in in IN cord-010092-uftc8inx 11339 30 the the DT cord-010092-uftc8inx 11339 31 leukodepleted leukodeplete VBN cord-010092-uftc8inx 11339 32 groups group NNS cord-010092-uftc8inx 11339 33 . . . cord-010092-uftc8inx 11340 1 Summary Summary NNP cord-010092-uftc8inx 11340 2 / / SYM cord-010092-uftc8inx 11340 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 11340 4 : : : cord-010092-uftc8inx 11341 1 There there EX cord-010092-uftc8inx 11341 2 was be VBD cord-010092-uftc8inx 11341 3 an an DT cord-010092-uftc8inx 11341 4 increase increase NN cord-010092-uftc8inx 11341 5 of of IN cord-010092-uftc8inx 11341 6 post post JJ cord-010092-uftc8inx 11341 7 - - JJ cord-010092-uftc8inx 11341 8 transfusion transfusion JJ cord-010092-uftc8inx 11341 9 platelet platelet NN cord-010092-uftc8inx 11341 10 CD62P cd62p NN cord-010092-uftc8inx 11341 11 expression expression NN cord-010092-uftc8inx 11341 12 in in IN cord-010092-uftc8inx 11341 13 patients patient NNS cord-010092-uftc8inx 11341 14 received receive VBD cord-010092-uftc8inx 11341 15 non non JJ cord-010092-uftc8inx 11341 16 - - JJ cord-010092-uftc8inx 11341 17 leukodepleted leukodepleted JJ cord-010092-uftc8inx 11341 18 , , , cord-010092-uftc8inx 11341 19 but but CC cord-010092-uftc8inx 11341 20 a a DT cord-010092-uftc8inx 11341 21 decrease decrease NN cord-010092-uftc8inx 11341 22 in in IN cord-010092-uftc8inx 11341 23 leukodepleted leukodepleted JJ cord-010092-uftc8inx 11341 24 PC pc NN cord-010092-uftc8inx 11341 25 transfusions transfusion NNS cord-010092-uftc8inx 11341 26 . . . cord-010092-uftc8inx 11342 1 Background background NN cord-010092-uftc8inx 11342 2 : : : cord-010092-uftc8inx 11343 1 Preoperative preoperative JJ cord-010092-uftc8inx 11343 2 anaemia anaemia NN cord-010092-uftc8inx 11343 3 is be VBZ cord-010092-uftc8inx 11343 4 a a DT cord-010092-uftc8inx 11343 5 common common JJ cord-010092-uftc8inx 11343 6 finding finding NN cord-010092-uftc8inx 11343 7 in in IN cord-010092-uftc8inx 11343 8 patients patient NNS cord-010092-uftc8inx 11343 9 undergoing undergo VBG cord-010092-uftc8inx 11343 10 surgery surgery NN cord-010092-uftc8inx 11343 11 and and CC cord-010092-uftc8inx 11343 12 often often RB cord-010092-uftc8inx 11343 13 neglected neglect VBN cord-010092-uftc8inx 11343 14 in in IN cord-010092-uftc8inx 11343 15 our -PRON- PRP$ cord-010092-uftc8inx 11343 16 country country NN cord-010092-uftc8inx 11343 17 . . . cord-010092-uftc8inx 11344 1 Aims aim VBZ cord-010092-uftc8inx 11344 2 : : : cord-010092-uftc8inx 11345 1 The the DT cord-010092-uftc8inx 11345 2 objective objective NN cord-010092-uftc8inx 11345 3 of of IN cord-010092-uftc8inx 11345 4 this this DT cord-010092-uftc8inx 11345 5 study study NN cord-010092-uftc8inx 11345 6 was be VBD cord-010092-uftc8inx 11345 7 to to TO cord-010092-uftc8inx 11345 8 evaluate evaluate VB cord-010092-uftc8inx 11345 9 Hb(values hb(value NNS cord-010092-uftc8inx 11345 10 and and CC cord-010092-uftc8inx 11345 11 the the DT cord-010092-uftc8inx 11345 12 identification identification NN cord-010092-uftc8inx 11345 13 of of IN cord-010092-uftc8inx 11345 14 cardiac cardiac JJ cord-010092-uftc8inx 11345 15 patients patient NNS cord-010092-uftc8inx 11345 16 who who WP cord-010092-uftc8inx 11345 17 entered enter VBD cord-010092-uftc8inx 11345 18 operation operation NN cord-010092-uftc8inx 11345 19 with with IN cord-010092-uftc8inx 11345 20 anaemia anaemia NN cord-010092-uftc8inx 11345 21 . . . cord-010092-uftc8inx 11346 1 And and CC cord-010092-uftc8inx 11346 2 also also RB cord-010092-uftc8inx 11346 3 to to TO cord-010092-uftc8inx 11346 4 study study VB cord-010092-uftc8inx 11346 5 the the DT cord-010092-uftc8inx 11346 6 correlation correlation NN cord-010092-uftc8inx 11346 7 between between IN cord-010092-uftc8inx 11346 8 Hb Hb NNP cord-010092-uftc8inx 11346 9 values value NNS cord-010092-uftc8inx 11346 10 and and CC cord-010092-uftc8inx 11346 11 the the DT cord-010092-uftc8inx 11346 12 number number NN cord-010092-uftc8inx 11346 13 of of IN cord-010092-uftc8inx 11346 14 RBC RBC NNP cord-010092-uftc8inx 11346 15 ( ( -LRB- cord-010092-uftc8inx 11346 16 red red JJ cord-010092-uftc8inx 11346 17 blood blood NN cord-010092-uftc8inx 11346 18 cell cell NN cord-010092-uftc8inx 11346 19 ) ) -RRB- cord-010092-uftc8inx 11346 20 transfused transfuse VBN cord-010092-uftc8inx 11346 21 unit unit NN cord-010092-uftc8inx 11346 22 Methods method NNS cord-010092-uftc8inx 11347 1 : : : cord-010092-uftc8inx 11347 2 This this DT cord-010092-uftc8inx 11347 3 is be VBZ cord-010092-uftc8inx 11347 4 a a DT cord-010092-uftc8inx 11347 5 retrospective retrospective JJ cord-010092-uftc8inx 11347 6 , , , cord-010092-uftc8inx 11347 7 descriptive descriptive JJ cord-010092-uftc8inx 11347 8 and and CC cord-010092-uftc8inx 11347 9 analytical analytical JJ cord-010092-uftc8inx 11347 10 study study NN cord-010092-uftc8inx 11347 11 . . . cord-010092-uftc8inx 11348 1 The the DT cord-010092-uftc8inx 11348 2 data datum NNS cord-010092-uftc8inx 11348 3 for for IN cord-010092-uftc8inx 11348 4 this this DT cord-010092-uftc8inx 11348 5 study study NN cord-010092-uftc8inx 11348 6 was be VBD cord-010092-uftc8inx 11348 7 collected collect VBN cord-010092-uftc8inx 11348 8 from from IN cord-010092-uftc8inx 11348 9 the the DT cord-010092-uftc8inx 11348 10 files file NNS cord-010092-uftc8inx 11348 11 in in IN cord-010092-uftc8inx 11348 12 the the DT cord-010092-uftc8inx 11348 13 Statistic statistic NN cord-010092-uftc8inx 11348 14 's 's POS cord-010092-uftc8inx 11348 15 Service Service NNP cord-010092-uftc8inx 11348 16 at at IN cord-010092-uftc8inx 11348 17 QSUT QSUT NNP cord-010092-uftc8inx 11348 18 ( ( -LRB- cord-010092-uftc8inx 11348 19 University University NNP cord-010092-uftc8inx 11348 20 Hospital Hospital NNP cord-010092-uftc8inx 11348 21 Center Center NNP cord-010092-uftc8inx 11348 22 " " '' cord-010092-uftc8inx 11348 23 Mother Mother NNP cord-010092-uftc8inx 11348 24 Teresa Teresa NNP cord-010092-uftc8inx 11348 25 " " '' cord-010092-uftc8inx 11348 26 ) ) -RRB- cord-010092-uftc8inx 11348 27 . . . cord-010092-uftc8inx 11349 1 The the DT cord-010092-uftc8inx 11349 2 object object NN cord-010092-uftc8inx 11349 3 of of IN cord-010092-uftc8inx 11349 4 our -PRON- PRP$ cord-010092-uftc8inx 11349 5 study study NN cord-010092-uftc8inx 11349 6 were be VBD cord-010092-uftc8inx 11349 7 the the DT cord-010092-uftc8inx 11349 8 files file NNS cord-010092-uftc8inx 11349 9 of of IN cord-010092-uftc8inx 11349 10 158 158 CD cord-010092-uftc8inx 11349 11 patients patient NNS cord-010092-uftc8inx 11349 12 hospitalized hospitalize VBN cord-010092-uftc8inx 11349 13 in in IN cord-010092-uftc8inx 11349 14 the the DT cord-010092-uftc8inx 11349 15 period period NN cord-010092-uftc8inx 11349 16 January January NNP cord-010092-uftc8inx 11349 17 -May -May NNP cord-010092-uftc8inx 11349 18 2018 2018 CD cord-010092-uftc8inx 11349 19 in in IN cord-010092-uftc8inx 11349 20 the the DT cord-010092-uftc8inx 11349 21 Cardiac Cardiac NNP cord-010092-uftc8inx 11349 22 Surgery Surgery NNP cord-010092-uftc8inx 11349 23 Ward Ward NNP cord-010092-uftc8inx 11349 24 , , , cord-010092-uftc8inx 11349 25 which which WDT cord-010092-uftc8inx 11349 26 were be VBD cord-010092-uftc8inx 11349 27 subjected subject VBN cord-010092-uftc8inx 11349 28 to to IN cord-010092-uftc8inx 11349 29 cardiac cardiac JJ cord-010092-uftc8inx 11349 30 surgery surgery NN cord-010092-uftc8inx 11349 31 . . . cord-010092-uftc8inx 11350 1 From from IN cord-010092-uftc8inx 11350 2 the the DT cord-010092-uftc8inx 11350 3 files file NNS cord-010092-uftc8inx 11350 4 were be VBD cord-010092-uftc8inx 11350 5 collected collect VBN cord-010092-uftc8inx 11350 6 data datum NNS cord-010092-uftc8inx 11350 7 on on IN cord-010092-uftc8inx 11350 8 age age NN cord-010092-uftc8inx 11350 9 , , , cord-010092-uftc8inx 11350 10 gender gender NN cord-010092-uftc8inx 11350 11 , , , cord-010092-uftc8inx 11350 12 primary primary JJ cord-010092-uftc8inx 11350 13 diagnosis diagnosis NN cord-010092-uftc8inx 11350 14 , , , cord-010092-uftc8inx 11350 15 accompanying accompany VBG cord-010092-uftc8inx 11350 16 diseases disease NNS cord-010092-uftc8inx 11350 17 . . . cord-010092-uftc8inx 11351 1 We -PRON- PRP cord-010092-uftc8inx 11351 2 also also RB cord-010092-uftc8inx 11351 3 collected collect VBD cord-010092-uftc8inx 11351 4 Hb Hb NNP cord-010092-uftc8inx 11351 5 , , , cord-010092-uftc8inx 11351 6 RBC RBC NNP cord-010092-uftc8inx 11351 7 , , , cord-010092-uftc8inx 11351 8 Htc Htc NNP cord-010092-uftc8inx 11351 9 ( ( -LRB- cord-010092-uftc8inx 11351 10 hematocrit hematocrit NN cord-010092-uftc8inx 11351 11 ) ) -RRB- cord-010092-uftc8inx 11351 12 , , , cord-010092-uftc8inx 11351 13 MCV MCV NNP cord-010092-uftc8inx 11351 14 ( ( -LRB- cord-010092-uftc8inx 11351 15 mean mean NNP cord-010092-uftc8inx 11351 16 corpuscular corpuscular JJ cord-010092-uftc8inx 11351 17 volume volume NN cord-010092-uftc8inx 11351 18 ) ) -RRB- cord-010092-uftc8inx 11351 19 , , , cord-010092-uftc8inx 11351 20 MCH MCH NNP cord-010092-uftc8inx 11351 21 ( ( -LRB- cord-010092-uftc8inx 11351 22 mean mean NNP cord-010092-uftc8inx 11351 23 corpuscular corpuscular JJ cord-010092-uftc8inx 11351 24 hemoglobin hemoglobin NN cord-010092-uftc8inx 11351 25 ) ) -RRB- cord-010092-uftc8inx 11351 26 , , , cord-010092-uftc8inx 11351 27 MCHC MCHC NNP cord-010092-uftc8inx 11351 28 ( ( -LRB- cord-010092-uftc8inx 11351 29 mean mean VB cord-010092-uftc8inx 11351 30 corpuscular corpuscular JJ cord-010092-uftc8inx 11351 31 hemoglobin hemoglobin NN cord-010092-uftc8inx 11351 32 concentration concentration NN cord-010092-uftc8inx 11351 33 ) ) -RRB- cord-010092-uftc8inx 11351 34 . . . cord-010092-uftc8inx 11352 1 From from IN cord-010092-uftc8inx 11352 2 the the DT cord-010092-uftc8inx 11352 3 Transfusion Transfusion NNP cord-010092-uftc8inx 11352 4 Service Service NNP cord-010092-uftc8inx 11352 5 at at IN cord-010092-uftc8inx 11352 6 QSUT QSUT NNP cord-010092-uftc8inx 11352 7 and and CC cord-010092-uftc8inx 11352 8 from from IN cord-010092-uftc8inx 11352 9 the the DT cord-010092-uftc8inx 11352 10 files file NNS cord-010092-uftc8inx 11352 11 were be VBD cord-010092-uftc8inx 11352 12 pulled pull VBN cord-010092-uftc8inx 11352 13 out out RP cord-010092-uftc8inx 11352 14 the the DT cord-010092-uftc8inx 11352 15 transfused transfuse VBN cord-010092-uftc8inx 11352 16 patients patient NNS cord-010092-uftc8inx 11352 17 and and CC cord-010092-uftc8inx 11352 18 the the DT cord-010092-uftc8inx 11352 19 number number NN cord-010092-uftc8inx 11352 20 of of IN cord-010092-uftc8inx 11352 21 transfused transfuse VBN cord-010092-uftc8inx 11352 22 units unit NNS cord-010092-uftc8inx 11352 23 . . . cord-010092-uftc8inx 11353 1 Results result NNS cord-010092-uftc8inx 11353 2 : : : cord-010092-uftc8inx 11354 1 Based base VBN cord-010092-uftc8inx 11354 2 on on IN cord-010092-uftc8inx 11354 3 the the DT cord-010092-uftc8inx 11354 4 WHO WHO NNP cord-010092-uftc8inx 11354 5 definition definition NN cord-010092-uftc8inx 11354 6 for for IN cord-010092-uftc8inx 11354 7 Anemia anemia NN cord-010092-uftc8inx 11354 8 ( ( -LRB- cord-010092-uftc8inx 11354 9 females female NNS cord-010092-uftc8inx 11354 10 < < XX cord-010092-uftc8inx 11354 11 12 12 CD cord-010092-uftc8inx 11354 12 g g NN cord-010092-uftc8inx 11354 13 / / SYM cord-010092-uftc8inx 11354 14 dl dl NN cord-010092-uftc8inx 11354 15 and and CC cord-010092-uftc8inx 11354 16 males male NNS cord-010092-uftc8inx 11354 17 < < XX cord-010092-uftc8inx 11354 18 13 13 CD cord-010092-uftc8inx 11354 19 g g NN cord-010092-uftc8inx 11354 20 / / SYM cord-010092-uftc8inx 11354 21 dl dl NNP cord-010092-uftc8inx 11354 22 ) ) -RRB- cord-010092-uftc8inx 11354 23 , , , cord-010092-uftc8inx 11354 24 from from IN cord-010092-uftc8inx 11354 25 the the DT cord-010092-uftc8inx 11354 26 158 158 CD cord-010092-uftc8inx 11354 27 patients patient NNS cord-010092-uftc8inx 11354 28 included include VBN cord-010092-uftc8inx 11354 29 in in IN cord-010092-uftc8inx 11354 30 the the DT cord-010092-uftc8inx 11354 31 study study NN cord-010092-uftc8inx 11354 32 , , , cord-010092-uftc8inx 11354 33 61 61 CD cord-010092-uftc8inx 11354 34 ( ( -LRB- cord-010092-uftc8inx 11354 35 39 39 CD cord-010092-uftc8inx 11354 36 % % NN cord-010092-uftc8inx 11354 37 ) ) -RRB- cord-010092-uftc8inx 11354 38 were be VBD cord-010092-uftc8inx 11354 39 anaemic anaemic JJ cord-010092-uftc8inx 11354 40 . . . cord-010092-uftc8inx 11355 1 From from IN cord-010092-uftc8inx 11355 2 117 117 CD cord-010092-uftc8inx 11355 3 males male NNS cord-010092-uftc8inx 11355 4 in in IN cord-010092-uftc8inx 11355 5 the the DT cord-010092-uftc8inx 11355 6 study study NN cord-010092-uftc8inx 11355 7 , , , cord-010092-uftc8inx 11355 8 40 40 CD cord-010092-uftc8inx 11355 9 ( ( -LRB- cord-010092-uftc8inx 11355 10 34 34 CD cord-010092-uftc8inx 11355 11 % % NN cord-010092-uftc8inx 11355 12 ) ) -RRB- cord-010092-uftc8inx 11355 13 of of IN cord-010092-uftc8inx 11355 14 them -PRON- PRP cord-010092-uftc8inx 11355 15 were be VBD cord-010092-uftc8inx 11355 16 anaemic anaemic JJ cord-010092-uftc8inx 11355 17 based base VBN cord-010092-uftc8inx 11355 18 on on IN cord-010092-uftc8inx 11355 19 Hb Hb NNP cord-010092-uftc8inx 11355 20 lab lab NN cord-010092-uftc8inx 11355 21 values value NNS cord-010092-uftc8inx 11355 22 , , , cord-010092-uftc8inx 11355 23 whereas whereas IN cord-010092-uftc8inx 11355 24 from from IN cord-010092-uftc8inx 11355 25 41 41 CD cord-010092-uftc8inx 11355 26 women woman NNS cord-010092-uftc8inx 11355 27 in in IN cord-010092-uftc8inx 11355 28 the the DT cord-010092-uftc8inx 11355 29 study study NN cord-010092-uftc8inx 11355 30 anaemic anaemic JJ cord-010092-uftc8inx 11355 31 were be VBD cord-010092-uftc8inx 11355 32 found find VBN cord-010092-uftc8inx 11355 33 to to TO cord-010092-uftc8inx 11355 34 be be VB cord-010092-uftc8inx 11355 35 21 21 CD cord-010092-uftc8inx 11355 36 ( ( -LRB- cord-010092-uftc8inx 11355 37 51 51 CD cord-010092-uftc8inx 11355 38 % % NN cord-010092-uftc8inx 11355 39 ) ) -RRB- cord-010092-uftc8inx 11355 40 of of IN cord-010092-uftc8inx 11355 41 them -PRON- PRP cord-010092-uftc8inx 11355 42 . . . cord-010092-uftc8inx 11356 1 From from IN cord-010092-uftc8inx 11356 2 the the DT cord-010092-uftc8inx 11356 3 61 61 CD cord-010092-uftc8inx 11356 4 anaemic anaemic JJ cord-010092-uftc8inx 11356 5 patients patient NNS cord-010092-uftc8inx 11356 6 in in IN cord-010092-uftc8inx 11356 7 the the DT cord-010092-uftc8inx 11356 8 study study NN cord-010092-uftc8inx 11356 9 , , , cord-010092-uftc8inx 11356 10 35 35 CD cord-010092-uftc8inx 11356 11 ( ( -LRB- cord-010092-uftc8inx 11356 12 57.4 57.4 CD cord-010092-uftc8inx 11356 13 % % NN cord-010092-uftc8inx 11356 14 ) ) -RRB- cord-010092-uftc8inx 11356 15 of of IN cord-010092-uftc8inx 11356 16 them -PRON- PRP cord-010092-uftc8inx 11356 17 with with IN cord-010092-uftc8inx 11356 18 mild mild JJ cord-010092-uftc8inx 11356 19 anaemia anaemia NN cord-010092-uftc8inx 11356 20 , , , cord-010092-uftc8inx 11356 21 23 23 CD cord-010092-uftc8inx 11356 22 ( ( -LRB- cord-010092-uftc8inx 11356 23 37.7 37.7 CD cord-010092-uftc8inx 11356 24 % % NN cord-010092-uftc8inx 11356 25 ) ) -RRB- cord-010092-uftc8inx 11356 26 with with IN cord-010092-uftc8inx 11356 27 moderate moderate JJ cord-010092-uftc8inx 11356 28 anaemia anaemia NN cord-010092-uftc8inx 11356 29 and and CC cord-010092-uftc8inx 11356 30 3 3 CD cord-010092-uftc8inx 11356 31 ( ( -LRB- cord-010092-uftc8inx 11356 32 4.9 4.9 CD cord-010092-uftc8inx 11356 33 % % NN cord-010092-uftc8inx 11356 34 ) ) -RRB- cord-010092-uftc8inx 11356 35 with with IN cord-010092-uftc8inx 11356 36 severe severe JJ cord-010092-uftc8inx 11356 37 anaemia anaemia NN cord-010092-uftc8inx 11356 38 . . . cord-010092-uftc8inx 11357 1 In in IN cord-010092-uftc8inx 11357 2 the the DT cord-010092-uftc8inx 11357 3 total total NN cord-010092-uftc8inx 11357 4 of of IN cord-010092-uftc8inx 11357 5 anaemic anaemic JJ cord-010092-uftc8inx 11357 6 female female JJ cord-010092-uftc8inx 11357 7 38.1 38.1 CD cord-010092-uftc8inx 11357 8 % % NN cord-010092-uftc8inx 11357 9 are be VBP cord-010092-uftc8inx 11357 10 under under IN cord-010092-uftc8inx 11357 11 65 65 CD cord-010092-uftc8inx 11357 12 , , , cord-010092-uftc8inx 11357 13 while while IN cord-010092-uftc8inx 11357 14 61.9 61.9 CD cord-010092-uftc8inx 11357 15 % % NN cord-010092-uftc8inx 11357 16 are be VBP cord-010092-uftc8inx 11357 17 over over IN cord-010092-uftc8inx 11357 18 / / SYM cord-010092-uftc8inx 11357 19 or or CC cord-010092-uftc8inx 11357 20 65 65 CD cord-010092-uftc8inx 11357 21 years year NNS cord-010092-uftc8inx 11357 22 old old JJ cord-010092-uftc8inx 11357 23 . . . cord-010092-uftc8inx 11358 1 In in IN cord-010092-uftc8inx 11358 2 the the DT cord-010092-uftc8inx 11358 3 total total NN cord-010092-uftc8inx 11358 4 of of IN cord-010092-uftc8inx 11358 5 anaemic anaemic JJ cord-010092-uftc8inx 11358 6 males male NNS cord-010092-uftc8inx 11358 7 , , , cord-010092-uftc8inx 11358 8 35 35 CD cord-010092-uftc8inx 11358 9 % % NN cord-010092-uftc8inx 11358 10 are be VBP cord-010092-uftc8inx 11358 11 under under IN cord-010092-uftc8inx 11358 12 65 65 CD cord-010092-uftc8inx 11358 13 , , , cord-010092-uftc8inx 11358 14 while while IN cord-010092-uftc8inx 11358 15 65 65 CD cord-010092-uftc8inx 11358 16 % % NN cord-010092-uftc8inx 11358 17 are be VBP cord-010092-uftc8inx 11358 18 over over IN cord-010092-uftc8inx 11358 19 / / SYM cord-010092-uftc8inx 11358 20 or or CC cord-010092-uftc8inx 11358 21 65 65 CD cord-010092-uftc8inx 11358 22 years year NNS cord-010092-uftc8inx 11358 23 old old JJ cord-010092-uftc8inx 11358 24 . . . cord-010092-uftc8inx 11359 1 It -PRON- PRP cord-010092-uftc8inx 11359 2 is be VBZ cord-010092-uftc8inx 11359 3 noticed notice VBN cord-010092-uftc8inx 11359 4 that that IN cord-010092-uftc8inx 11359 5 most most JJS cord-010092-uftc8inx 11359 6 of of IN cord-010092-uftc8inx 11359 7 them -PRON- PRP cord-010092-uftc8inx 11359 8 are be VBP cord-010092-uftc8inx 11359 9 with with IN cord-010092-uftc8inx 11359 10 normochromic normochromic JJ cord-010092-uftc8inx 11359 11 normocytic normocytic JJ cord-010092-uftc8inx 11359 12 67.2 67.2 CD cord-010092-uftc8inx 11359 13 % % NN cord-010092-uftc8inx 11359 14 , , , cord-010092-uftc8inx 11359 15 normocytic normocytic JJ cord-010092-uftc8inx 11359 16 hypochromic hypochromic JJ cord-010092-uftc8inx 11359 17 anaemia anaemia NN cord-010092-uftc8inx 11359 18 16.4 16.4 CD cord-010092-uftc8inx 11359 19 % % NN cord-010092-uftc8inx 11359 20 , , , cord-010092-uftc8inx 11360 1 hyperchromic hyperchromic NNP cord-010092-uftc8inx 11360 2 microcytic microcytic NNP cord-010092-uftc8inx 11360 3 anaemia anaemia NN cord-010092-uftc8inx 11360 4 8.2 8.2 CD cord-010092-uftc8inx 11360 5 % % NN cord-010092-uftc8inx 11360 6 , , , cord-010092-uftc8inx 11360 7 macrocytic macrocytic JJ cord-010092-uftc8inx 11360 8 normochromic normochromic JJ cord-010092-uftc8inx 11360 9 anaemia anaemia NN cord-010092-uftc8inx 11360 10 and and CC cord-010092-uftc8inx 11360 11 macrocytic macrocytic VBD cord-010092-uftc8inx 11360 12 Hypochromic Hypochromic NNP cord-010092-uftc8inx 11360 13 anaemia anaemia NN cord-010092-uftc8inx 11360 14 respectively respectively RB cord-010092-uftc8inx 11360 15 1.6 1.6 CD cord-010092-uftc8inx 11360 16 % % NN cord-010092-uftc8inx 11360 17 and and CC cord-010092-uftc8inx 11360 18 microcytic microcytic JJ cord-010092-uftc8inx 11360 19 normochromic normochromic JJ cord-010092-uftc8inx 11360 20 anaemia anaemia NN cord-010092-uftc8inx 11360 21 4.9 4.9 CD cord-010092-uftc8inx 11360 22 % % NN cord-010092-uftc8inx 11360 23 . . . cord-010092-uftc8inx 11361 1 The the DT cord-010092-uftc8inx 11361 2 average average JJ cord-010092-uftc8inx 11361 3 value value NN cord-010092-uftc8inx 11361 4 of of IN cord-010092-uftc8inx 11361 5 preoperative preoperative JJ cord-010092-uftc8inx 11361 6 Hb Hb NNP cord-010092-uftc8inx 11361 7 decreased decrease VBD cord-010092-uftc8inx 11361 8 from from IN cord-010092-uftc8inx 11361 9 12.8 12.8 CD cord-010092-uftc8inx 11361 10 g g NN cord-010092-uftc8inx 11361 11 / / SYM cord-010092-uftc8inx 11361 12 dl dl NN cord-010092-uftc8inx 11361 13 before before IN cord-010092-uftc8inx 11361 14 surgery surgery NN cord-010092-uftc8inx 11361 15 to to IN cord-010092-uftc8inx 11361 16 10.3 10.3 CD cord-010092-uftc8inx 11361 17 g g NN cord-010092-uftc8inx 11361 18 / / SYM cord-010092-uftc8inx 11361 19 dl dl NN cord-010092-uftc8inx 11361 20 after after IN cord-010092-uftc8inx 11361 21 surgery surgery NN cord-010092-uftc8inx 11361 22 , , , cord-010092-uftc8inx 11361 23 so so CC cord-010092-uftc8inx 11361 24 there there EX cord-010092-uftc8inx 11361 25 is be VBZ cord-010092-uftc8inx 11361 26 a a DT cord-010092-uftc8inx 11361 27 decrease decrease NN cord-010092-uftc8inx 11361 28 of of IN cord-010092-uftc8inx 11361 29 approximately approximately RB cord-010092-uftc8inx 11361 30 2.5 2.5 CD cord-010092-uftc8inx 11361 31 g g NN cord-010092-uftc8inx 11361 32 / / SYM cord-010092-uftc8inx 11361 33 dl dl NN cord-010092-uftc8inx 11361 34 of of IN cord-010092-uftc8inx 11361 35 Hb Hb NNP cord-010092-uftc8inx 11361 36 value value NN cord-010092-uftc8inx 11361 37 . . . cord-010092-uftc8inx 11362 1 In in IN cord-010092-uftc8inx 11362 2 our -PRON- PRP$ cord-010092-uftc8inx 11362 3 158 158 CD cord-010092-uftc8inx 11362 4 patients patient NNS cord-010092-uftc8inx 11362 5 , , , cord-010092-uftc8inx 11362 6 48 48 CD cord-010092-uftc8inx 11362 7 % % NN cord-010092-uftc8inx 11362 8 ( ( -LRB- cord-010092-uftc8inx 11362 9 76 76 CD cord-010092-uftc8inx 11362 10 ) ) -RRB- cord-010092-uftc8inx 11362 11 were be VBD cord-010092-uftc8inx 11362 12 transfused transfuse VBN cord-010092-uftc8inx 11362 13 and and CC cord-010092-uftc8inx 11362 14 the the DT cord-010092-uftc8inx 11362 15 remaining remain VBG cord-010092-uftc8inx 11362 16 52 52 CD cord-010092-uftc8inx 11362 17 % % NN cord-010092-uftc8inx 11362 18 ( ( -LRB- cord-010092-uftc8inx 11362 19 82 82 CD cord-010092-uftc8inx 11362 20 ) ) -RRB- cord-010092-uftc8inx 11362 21 were be VBD cord-010092-uftc8inx 11362 22 not not RB cord-010092-uftc8inx 11362 23 transfused transfuse VBN cord-010092-uftc8inx 11362 24 . . . cord-010092-uftc8inx 11363 1 From from IN cord-010092-uftc8inx 11363 2 76 76 CD cord-010092-uftc8inx 11363 3 transfused transfuse VBN cord-010092-uftc8inx 11363 4 patients patient NNS cord-010092-uftc8inx 11363 5 41 41 CD cord-010092-uftc8inx 11363 6 ( ( -LRB- cord-010092-uftc8inx 11363 7 54 54 CD cord-010092-uftc8inx 11363 8 % % NN cord-010092-uftc8inx 11363 9 ) ) -RRB- cord-010092-uftc8inx 11363 10 patients patient NNS cord-010092-uftc8inx 11363 11 were be VBD cord-010092-uftc8inx 11363 12 anaemic anaemic JJ cord-010092-uftc8inx 11363 13 . . . cord-010092-uftc8inx 11364 1 The the DT cord-010092-uftc8inx 11364 2 correlation correlation NN cord-010092-uftc8inx 11364 3 between between IN cord-010092-uftc8inx 11364 4 the the DT cord-010092-uftc8inx 11364 5 values value NNS cord-010092-uftc8inx 11364 6 of of IN cord-010092-uftc8inx 11364 7 Hb Hb NNP cord-010092-uftc8inx 11364 8 , , , cord-010092-uftc8inx 11364 9 RBC RBC NNP cord-010092-uftc8inx 11364 10 , , , cord-010092-uftc8inx 11364 11 Htc Htc NNP cord-010092-uftc8inx 11364 12 and and CC cord-010092-uftc8inx 11364 13 the the DT cord-010092-uftc8inx 11364 14 number number NN cord-010092-uftc8inx 11364 15 of of IN cord-010092-uftc8inx 11364 16 transfusions transfusion NNS cord-010092-uftc8inx 11364 17 shows show VBZ cord-010092-uftc8inx 11364 18 that that IN cord-010092-uftc8inx 11364 19 with with IN cord-010092-uftc8inx 11364 20 the the DT cord-010092-uftc8inx 11364 21 decrease decrease NN cord-010092-uftc8inx 11364 22 of of IN cord-010092-uftc8inx 11364 23 these these DT cord-010092-uftc8inx 11364 24 values value NNS cord-010092-uftc8inx 11364 25 the the DT cord-010092-uftc8inx 11364 26 number number NN cord-010092-uftc8inx 11364 27 of of IN cord-010092-uftc8inx 11364 28 transfused transfuse VBN cord-010092-uftc8inx 11364 29 units unit NNS cord-010092-uftc8inx 11364 30 increases increase NNS cord-010092-uftc8inx 11364 31 . . . cord-010092-uftc8inx 11365 1 Summary Summary NNP cord-010092-uftc8inx 11365 2 / / SYM cord-010092-uftc8inx 11365 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 11365 4 : : : cord-010092-uftc8inx 11366 1 The the DT cord-010092-uftc8inx 11366 2 diagnose diagnose NN cord-010092-uftc8inx 11366 3 of of IN cord-010092-uftc8inx 11366 4 anaemia anaemia NN cord-010092-uftc8inx 11366 5 is be VBZ cord-010092-uftc8inx 11366 6 underestimated underestimate VBN cord-010092-uftc8inx 11366 7 before before IN cord-010092-uftc8inx 11366 8 surgical surgical JJ cord-010092-uftc8inx 11366 9 intervention intervention NN cord-010092-uftc8inx 11366 10 in in IN cord-010092-uftc8inx 11366 11 our -PRON- PRP$ cord-010092-uftc8inx 11366 12 country country NN cord-010092-uftc8inx 11366 13 and and CC cord-010092-uftc8inx 11366 14 investigation investigation NN cord-010092-uftc8inx 11366 15 of of IN cord-010092-uftc8inx 11366 16 Hb Hb NNP cord-010092-uftc8inx 11366 17 low low JJ cord-010092-uftc8inx 11366 18 values value NNS cord-010092-uftc8inx 11366 19 do do VBP cord-010092-uftc8inx 11366 20 not not RB cord-010092-uftc8inx 11366 21 take take VB cord-010092-uftc8inx 11366 22 the the DT cord-010092-uftc8inx 11366 23 proper proper JJ cord-010092-uftc8inx 11366 24 importance importance NN cord-010092-uftc8inx 11366 25 to to TO cord-010092-uftc8inx 11366 26 find find VB cord-010092-uftc8inx 11366 27 probable probable JJ cord-010092-uftc8inx 11366 28 cause cause NN cord-010092-uftc8inx 11366 29 and and CC cord-010092-uftc8inx 11366 30 correct correct VB cord-010092-uftc8inx 11366 31 it -PRON- PRP cord-010092-uftc8inx 11366 32 before before IN cord-010092-uftc8inx 11366 33 surgical surgical JJ cord-010092-uftc8inx 11366 34 intervention intervention NN cord-010092-uftc8inx 11366 35 . . . cord-010092-uftc8inx 11367 1 The the DT cord-010092-uftc8inx 11367 2 lower low JJR cord-010092-uftc8inx 11367 3 the the DT cord-010092-uftc8inx 11367 4 Hb Hb NNP cord-010092-uftc8inx 11367 5 values value NNS cord-010092-uftc8inx 11367 6 , , , cord-010092-uftc8inx 11367 7 the the DT cord-010092-uftc8inx 11367 8 greater great JJR cord-010092-uftc8inx 11367 9 the the DT cord-010092-uftc8inx 11367 10 chance chance NN cord-010092-uftc8inx 11367 11 to to TO cord-010092-uftc8inx 11367 12 be be VB cord-010092-uftc8inx 11367 13 transfused transfuse VBN cord-010092-uftc8inx 11367 14 and and CC cord-010092-uftc8inx 11367 15 the the DT cord-010092-uftc8inx 11367 16 number number NN cord-010092-uftc8inx 11367 17 of of IN cord-010092-uftc8inx 11367 18 RBC RBC NNP cord-010092-uftc8inx 11367 19 transfused transfuse VBN cord-010092-uftc8inx 11367 20 units unit NNS cord-010092-uftc8inx 11367 21 . . . cord-010092-uftc8inx 11368 1 Failure failure NN cord-010092-uftc8inx 11368 2 to to TO cord-010092-uftc8inx 11368 3 correct correct VB cord-010092-uftc8inx 11368 4 Hb Hb NNP cord-010092-uftc8inx 11368 5 values value NNS cord-010092-uftc8inx 11368 6 before before IN cord-010092-uftc8inx 11368 7 surgery surgery NN cord-010092-uftc8inx 11368 8 results result NNS cord-010092-uftc8inx 11368 9 in in IN cord-010092-uftc8inx 11368 10 unnecessary unnecessary JJ cord-010092-uftc8inx 11368 11 transfusions transfusion NNS cord-010092-uftc8inx 11368 12 for for IN cord-010092-uftc8inx 11368 13 the the DT cord-010092-uftc8inx 11368 14 patients patient NNS cord-010092-uftc8inx 11368 15 or or CC cord-010092-uftc8inx 11368 16 which which WDT cord-010092-uftc8inx 11368 17 could could MD cord-010092-uftc8inx 11368 18 have have VB cord-010092-uftc8inx 11368 19 been be VBN cord-010092-uftc8inx 11368 20 avoided avoid VBN cord-010092-uftc8inx 11368 21 , , , cord-010092-uftc8inx 11368 22 eliminating eliminate VBG cord-010092-uftc8inx 11368 23 also also RB cord-010092-uftc8inx 11368 24 the the DT cord-010092-uftc8inx 11368 25 risk risk NN cord-010092-uftc8inx 11368 26 of of IN cord-010092-uftc8inx 11368 27 transfusion transfusion NN cord-010092-uftc8inx 11368 28 complications complication NNS cord-010092-uftc8inx 11368 29 . . . cord-010092-uftc8inx 11369 1 Background background NN cord-010092-uftc8inx 11369 2 : : : cord-010092-uftc8inx 11370 1 Alloimmunization alloimmunization NN cord-010092-uftc8inx 11370 2 after after IN cord-010092-uftc8inx 11370 3 red red JJ cord-010092-uftc8inx 11370 4 blood blood NN cord-010092-uftc8inx 11370 5 cell cell NN cord-010092-uftc8inx 11370 6 transfusion transfusion NN cord-010092-uftc8inx 11370 7 is be VBZ cord-010092-uftc8inx 11370 8 affected affect VBN cord-010092-uftc8inx 11370 9 by by IN cord-010092-uftc8inx 11370 10 various various JJ cord-010092-uftc8inx 11370 11 factors factor NNS cord-010092-uftc8inx 11370 12 . . . cord-010092-uftc8inx 11371 1 It -PRON- PRP cord-010092-uftc8inx 11371 2 is be VBZ cord-010092-uftc8inx 11371 3 known know VBN cord-010092-uftc8inx 11371 4 that that IN cord-010092-uftc8inx 11371 5 the the DT cord-010092-uftc8inx 11371 6 incidence incidence NN cord-010092-uftc8inx 11371 7 of of IN cord-010092-uftc8inx 11371 8 alloimmunization alloimmunization NN cord-010092-uftc8inx 11371 9 increases increase NNS cord-010092-uftc8inx 11371 10 in in IN cord-010092-uftc8inx 11371 11 certain certain JJ cord-010092-uftc8inx 11371 12 diseases disease NNS cord-010092-uftc8inx 11371 13 . . . cord-010092-uftc8inx 11372 1 Extended extended JJ cord-010092-uftc8inx 11372 2 red red JJ cord-010092-uftc8inx 11372 3 blood blood NN cord-010092-uftc8inx 11372 4 cell cell NN cord-010092-uftc8inx 11372 5 matching matching NN cord-010092-uftc8inx 11372 6 can can MD cord-010092-uftc8inx 11372 7 be be VB cord-010092-uftc8inx 11372 8 used use VBN cord-010092-uftc8inx 11372 9 to to TO cord-010092-uftc8inx 11372 10 prevent prevent VB cord-010092-uftc8inx 11372 11 the the DT cord-010092-uftc8inx 11372 12 development development NN cord-010092-uftc8inx 11372 13 of of IN cord-010092-uftc8inx 11372 14 alloimmunization alloimmunization NN cord-010092-uftc8inx 11372 15 in in IN cord-010092-uftc8inx 11372 16 diseases disease NNS cord-010092-uftc8inx 11372 17 which which WDT cord-010092-uftc8inx 11372 18 the the DT cord-010092-uftc8inx 11372 19 rate rate NN cord-010092-uftc8inx 11372 20 of of IN cord-010092-uftc8inx 11372 21 alloimmunization alloimmunization NN cord-010092-uftc8inx 11372 22 is be VBZ cord-010092-uftc8inx 11372 23 increased increase VBN cord-010092-uftc8inx 11372 24 . . . cord-010092-uftc8inx 11373 1 In in IN cord-010092-uftc8inx 11373 2 Asia Asia NNP cord-010092-uftc8inx 11373 3 , , , cord-010092-uftc8inx 11373 4 extended extend VBD cord-010092-uftc8inx 11373 5 red red JJ cord-010092-uftc8inx 11373 6 blood blood NN cord-010092-uftc8inx 11373 7 cell cell NN cord-010092-uftc8inx 11373 8 matching matching NN cord-010092-uftc8inx 11373 9 is be VBZ cord-010092-uftc8inx 11373 10 not not RB cord-010092-uftc8inx 11373 11 actively actively RB cord-010092-uftc8inx 11373 12 implemented implement VBN cord-010092-uftc8inx 11373 13 . . . cord-010092-uftc8inx 11374 1 Aims aim VBZ cord-010092-uftc8inx 11374 2 : : : cord-010092-uftc8inx 11374 3 We -PRON- PRP cord-010092-uftc8inx 11374 4 tried try VBD cord-010092-uftc8inx 11374 5 to to TO cord-010092-uftc8inx 11374 6 investigate investigate VB cord-010092-uftc8inx 11374 7 whether whether IN cord-010092-uftc8inx 11374 8 there there EX cord-010092-uftc8inx 11374 9 is be VBZ cord-010092-uftc8inx 11374 10 a a DT cord-010092-uftc8inx 11374 11 difference difference NN cord-010092-uftc8inx 11374 12 in in IN cord-010092-uftc8inx 11374 13 the the DT cord-010092-uftc8inx 11374 14 disease disease NN cord-010092-uftc8inx 11374 15 categories category NNS cord-010092-uftc8inx 11374 16 between between IN cord-010092-uftc8inx 11374 17 unexpected unexpected JJ cord-010092-uftc8inx 11374 18 red red JJ cord-010092-uftc8inx 11374 19 blood blood NN cord-010092-uftc8inx 11374 20 cell cell NN cord-010092-uftc8inx 11374 21 antibody antibody NN cord-010092-uftc8inx 11374 22 positive positive JJ cord-010092-uftc8inx 11374 23 and and CC cord-010092-uftc8inx 11374 24 negative negative JJ cord-010092-uftc8inx 11374 25 groups group NNS cord-010092-uftc8inx 11374 26 . . . cord-010092-uftc8inx 11375 1 Methods method NNS cord-010092-uftc8inx 11375 2 : : : cord-010092-uftc8inx 11376 1 From from IN cord-010092-uftc8inx 11376 2 January January NNP cord-010092-uftc8inx 11376 3 , , , cord-010092-uftc8inx 11376 4 2003 2003 CD cord-010092-uftc8inx 11376 5 to to IN cord-010092-uftc8inx 11376 6 December December NNP cord-010092-uftc8inx 11376 7 , , , cord-010092-uftc8inx 11376 8 2017 2017 CD cord-010092-uftc8inx 11376 9 , , , cord-010092-uftc8inx 11376 10 the the DT cord-010092-uftc8inx 11376 11 diseases disease NNS cord-010092-uftc8inx 11376 12 of of IN cord-010092-uftc8inx 11376 13 the the DT cord-010092-uftc8inx 11376 14 patients patient NNS cord-010092-uftc8inx 11376 15 who who WP cord-010092-uftc8inx 11376 16 had have VBD cord-010092-uftc8inx 11376 17 undergone undergo VBN cord-010092-uftc8inx 11376 18 unexpected unexpected JJ cord-010092-uftc8inx 11376 19 red red JJ cord-010092-uftc8inx 11376 20 blood blood NN cord-010092-uftc8inx 11376 21 cell cell NN cord-010092-uftc8inx 11376 22 antibody antibody NN cord-010092-uftc8inx 11376 23 identification identification NN cord-010092-uftc8inx 11376 24 test test NN cord-010092-uftc8inx 11376 25 at at IN cord-010092-uftc8inx 11376 26 Dong Dong NNP cord-010092-uftc8inx 11376 27 - - HYPH cord-010092-uftc8inx 11376 28 A A NNP cord-010092-uftc8inx 11376 29 University University NNP cord-010092-uftc8inx 11376 30 Hospital Hospital NNP cord-010092-uftc8inx 11376 31 was be VBD cord-010092-uftc8inx 11376 32 examined examine VBN cord-010092-uftc8inx 11376 33 through through IN cord-010092-uftc8inx 11376 34 medical medical JJ cord-010092-uftc8inx 11376 35 records record NNS cord-010092-uftc8inx 11376 36 . . . cord-010092-uftc8inx 11377 1 From from IN cord-010092-uftc8inx 11377 2 January January NNP cord-010092-uftc8inx 11377 3 2008 2008 CD cord-010092-uftc8inx 11377 4 to to IN cord-010092-uftc8inx 11377 5 December December NNP cord-010092-uftc8inx 11377 6 2009 2009 CD cord-010092-uftc8inx 11377 7 , , , cord-010092-uftc8inx 11377 8 the the DT cord-010092-uftc8inx 11377 9 diagnosis diagnosis NN cord-010092-uftc8inx 11377 10 was be VBD cord-010092-uftc8inx 11377 11 made make VBN cord-010092-uftc8inx 11377 12 on on IN cord-010092-uftc8inx 11377 13 patients patient NNS cord-010092-uftc8inx 11377 14 who who WP cord-010092-uftc8inx 11377 15 had have VBD cord-010092-uftc8inx 11377 16 two two CD cord-010092-uftc8inx 11377 17 or or CC cord-010092-uftc8inx 11377 18 more more RBR cord-010092-uftc8inx 11377 19 unexpected unexpected JJ cord-010092-uftc8inx 11377 20 antibody antibody NN cord-010092-uftc8inx 11377 21 screening screening NN cord-010092-uftc8inx 11377 22 tests test NNS cord-010092-uftc8inx 11377 23 . . . cord-010092-uftc8inx 11378 1 We -PRON- PRP cord-010092-uftc8inx 11378 2 analyzed analyze VBD cord-010092-uftc8inx 11378 3 the the DT cord-010092-uftc8inx 11378 4 frequency frequency NN cord-010092-uftc8inx 11378 5 difference difference NN cord-010092-uftc8inx 11378 6 of of IN cord-010092-uftc8inx 11378 7 disease disease NN cord-010092-uftc8inx 11378 8 category category NN cord-010092-uftc8inx 11378 9 between between IN cord-010092-uftc8inx 11378 10 two two CD cord-010092-uftc8inx 11378 11 groups group NNS cord-010092-uftc8inx 11378 12 . . . cord-010092-uftc8inx 11379 1 Results result NNS cord-010092-uftc8inx 11379 2 : : : cord-010092-uftc8inx 11380 1 A a DT cord-010092-uftc8inx 11380 2 total total NN cord-010092-uftc8inx 11380 3 of of IN cord-010092-uftc8inx 11380 4 988 988 CD cord-010092-uftc8inx 11380 5 patients patient NNS cord-010092-uftc8inx 11380 6 were be VBD cord-010092-uftc8inx 11380 7 performed perform VBN cord-010092-uftc8inx 11380 8 with with IN cord-010092-uftc8inx 11380 9 unexpected unexpected JJ cord-010092-uftc8inx 11380 10 antibody antibody NN cord-010092-uftc8inx 11380 11 identification identification NN cord-010092-uftc8inx 11380 12 tests test NNS cord-010092-uftc8inx 11380 13 . . . cord-010092-uftc8inx 11381 1 Of of IN cord-010092-uftc8inx 11381 2 1896 1896 CD cord-010092-uftc8inx 11381 3 patients patient NNS cord-010092-uftc8inx 11381 4 who who WP cord-010092-uftc8inx 11381 5 underwent undergo VBD cord-010092-uftc8inx 11381 6 more more JJR cord-010092-uftc8inx 11381 7 than than IN cord-010092-uftc8inx 11381 8 2 2 CD cord-010092-uftc8inx 11381 9 screening screening NN cord-010092-uftc8inx 11381 10 tests test NNS cord-010092-uftc8inx 11381 11 , , , cord-010092-uftc8inx 11381 12 25 25 CD cord-010092-uftc8inx 11381 13 ( ( -LRB- cord-010092-uftc8inx 11381 14 1.3 1.3 CD cord-010092-uftc8inx 11381 15 % % NN cord-010092-uftc8inx 11381 16 ) ) -RRB- cord-010092-uftc8inx 11381 17 were be VBD cord-010092-uftc8inx 11381 18 positive positive JJ cord-010092-uftc8inx 11381 19 . . . cord-010092-uftc8inx 11382 1 1871 1871 CD cord-010092-uftc8inx 11382 2 were be VBD cord-010092-uftc8inx 11382 3 consistently consistently RB cord-010092-uftc8inx 11382 4 unexpected unexpected JJ cord-010092-uftc8inx 11382 5 antibody antibody NN cord-010092-uftc8inx 11382 6 negative negative JJ cord-010092-uftc8inx 11382 7 . . . cord-010092-uftc8inx 11383 1 The the DT cord-010092-uftc8inx 11383 2 patients patient NNS cord-010092-uftc8inx 11383 3 with with IN cord-010092-uftc8inx 11383 4 solid solid JJ cord-010092-uftc8inx 11383 5 tumors tumor NNS cord-010092-uftc8inx 11383 6 ( ( -LRB- cord-010092-uftc8inx 11383 7 N n NN cord-010092-uftc8inx 11383 8 = = SYM cord-010092-uftc8inx 11383 9 375 375 CD cord-010092-uftc8inx 11383 10 , , , cord-010092-uftc8inx 11383 11 56.3 56.3 CD cord-010092-uftc8inx 11383 12 % % NN cord-010092-uftc8inx 11383 13 ) ) -RRB- cord-010092-uftc8inx 11383 14 and and CC cord-010092-uftc8inx 11383 15 those those DT cord-010092-uftc8inx 11383 16 with with IN cord-010092-uftc8inx 11383 17 hematologic hematologic JJ cord-010092-uftc8inx 11383 18 diseases disease NNS cord-010092-uftc8inx 11383 19 ( ( -LRB- cord-010092-uftc8inx 11383 20 N n NN cord-010092-uftc8inx 11383 21 = = SYM cord-010092-uftc8inx 11383 22 112 112 CD cord-010092-uftc8inx 11383 23 , , , cord-010092-uftc8inx 11383 24 16.8 16.8 CD cord-010092-uftc8inx 11383 25 % % NN cord-010092-uftc8inx 11383 26 ) ) -RRB- cord-010092-uftc8inx 11383 27 had have VBD cord-010092-uftc8inx 11383 28 a a DT cord-010092-uftc8inx 11383 29 higher high JJR cord-010092-uftc8inx 11383 30 incidence incidence NN cord-010092-uftc8inx 11383 31 in in IN cord-010092-uftc8inx 11383 32 unexpected unexpected JJ cord-010092-uftc8inx 11383 33 antibody antibody NN cord-010092-uftc8inx 11383 34 positive positive JJ cord-010092-uftc8inx 11383 35 group group NN cord-010092-uftc8inx 11383 36 . . . cord-010092-uftc8inx 11384 1 The the DT cord-010092-uftc8inx 11384 2 patients patient NNS cord-010092-uftc8inx 11384 3 with with IN cord-010092-uftc8inx 11384 4 myeloid myeloid JJ cord-010092-uftc8inx 11384 5 malignancy malignancy NN cord-010092-uftc8inx 11384 6 had have VBD cord-010092-uftc8inx 11384 7 a a DT cord-010092-uftc8inx 11384 8 significantly significantly RB cord-010092-uftc8inx 11384 9 higher high JJR cord-010092-uftc8inx 11384 10 frequency frequency NN cord-010092-uftc8inx 11384 11 than than IN cord-010092-uftc8inx 11384 12 lymphoid lymphoid JJ cord-010092-uftc8inx 11384 13 malignancy malignancy NN cord-010092-uftc8inx 11385 1 ( ( -LRB- cord-010092-uftc8inx 11385 2 P p NN cord-010092-uftc8inx 11385 3 = = SYM cord-010092-uftc8inx 11385 4 0.0002 0.0002 CD cord-010092-uftc8inx 11385 5 ) ) -RRB- cord-010092-uftc8inx 11385 6 . . . cord-010092-uftc8inx 11386 1 The the DT cord-010092-uftc8inx 11386 2 frequency frequency NN cord-010092-uftc8inx 11386 3 of of IN cord-010092-uftc8inx 11386 4 patients patient NNS cord-010092-uftc8inx 11386 5 with with IN cord-010092-uftc8inx 11386 6 liver liver NN cord-010092-uftc8inx 11386 7 cirrhosis cirrhosis NN cord-010092-uftc8inx 11386 8 was be VBD cord-010092-uftc8inx 11386 9 significantly significantly RB cord-010092-uftc8inx 11386 10 higher high JJR cord-010092-uftc8inx 11386 11 in in IN cord-010092-uftc8inx 11386 12 the the DT cord-010092-uftc8inx 11386 13 unexpected unexpected JJ cord-010092-uftc8inx 11386 14 antibody antibody NN cord-010092-uftc8inx 11386 15 positive positive JJ cord-010092-uftc8inx 11386 16 group group NN cord-010092-uftc8inx 11386 17 ( ( -LRB- cord-010092-uftc8inx 11386 18 65/988 65/988 CD cord-010092-uftc8inx 11386 19 , , , cord-010092-uftc8inx 11386 20 6.6 6.6 CD cord-010092-uftc8inx 11386 21 % % NN cord-010092-uftc8inx 11386 22 ) ) -RRB- cord-010092-uftc8inx 11386 23 than than IN cord-010092-uftc8inx 11386 24 in in IN cord-010092-uftc8inx 11386 25 the the DT cord-010092-uftc8inx 11386 26 negative negative JJ cord-010092-uftc8inx 11386 27 group group NN cord-010092-uftc8inx 11386 28 ( ( -LRB- cord-010092-uftc8inx 11386 29 77/1871 77/1871 CD cord-010092-uftc8inx 11386 30 , , , cord-010092-uftc8inx 11386 31 4.1 4.1 CD cord-010092-uftc8inx 11386 32 % % NN cord-010092-uftc8inx 11386 33 ) ) -RRB- cord-010092-uftc8inx 11387 1 ( ( -LRB- cord-010092-uftc8inx 11387 2 P p NN cord-010092-uftc8inx 11387 3 = = SYM cord-010092-uftc8inx 11387 4 0.006 0.006 CD cord-010092-uftc8inx 11387 5 ) ) -RRB- cord-010092-uftc8inx 11387 6 . . . cord-010092-uftc8inx 11388 1 The the DT cord-010092-uftc8inx 11388 2 incidence incidence NN cord-010092-uftc8inx 11388 3 of of IN cord-010092-uftc8inx 11388 4 non non JJ cord-010092-uftc8inx 11388 5 - - JJ cord-010092-uftc8inx 11388 6 Hodgkin Hodgkin NNP cord-010092-uftc8inx 11388 7 lymphoma lymphoma NN cord-010092-uftc8inx 11388 8 was be VBD cord-010092-uftc8inx 11388 9 significantly significantly RB cord-010092-uftc8inx 11388 10 higher high JJR cord-010092-uftc8inx 11388 11 in in IN cord-010092-uftc8inx 11388 12 the the DT cord-010092-uftc8inx 11388 13 unexpected unexpected JJ cord-010092-uftc8inx 11388 14 antibody antibody NN cord-010092-uftc8inx 11388 15 negative negative JJ cord-010092-uftc8inx 11388 16 group group NN cord-010092-uftc8inx 11388 17 ( ( -LRB- cord-010092-uftc8inx 11388 18 28/1871 28/1871 CD cord-010092-uftc8inx 11388 19 , , , cord-010092-uftc8inx 11388 20 1.5 1.5 CD cord-010092-uftc8inx 11388 21 % % NN cord-010092-uftc8inx 11388 22 ) ) -RRB- cord-010092-uftc8inx 11388 23 than than IN cord-010092-uftc8inx 11388 24 in in IN cord-010092-uftc8inx 11388 25 the the DT cord-010092-uftc8inx 11388 26 positive positive JJ cord-010092-uftc8inx 11388 27 group group NN cord-010092-uftc8inx 11388 28 ( ( -LRB- cord-010092-uftc8inx 11388 29 5/988 5/988 CD cord-010092-uftc8inx 11388 30 , , , cord-010092-uftc8inx 11388 31 0.5 0.5 CD cord-010092-uftc8inx 11388 32 % % NN cord-010092-uftc8inx 11388 33 ) ) -RRB- cord-010092-uftc8inx 11389 1 ( ( -LRB- cord-010092-uftc8inx 11389 2 P p NN cord-010092-uftc8inx 11389 3 = = SYM cord-010092-uftc8inx 11389 4 0.019 0.019 CD cord-010092-uftc8inx 11389 5 ) ) -RRB- cord-010092-uftc8inx 11389 6 . . . cord-010092-uftc8inx 11390 1 Summary Summary NNP cord-010092-uftc8inx 11390 2 / / SYM cord-010092-uftc8inx 11390 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 11390 4 : : : cord-010092-uftc8inx 11391 1 There there EX cord-010092-uftc8inx 11391 2 was be VBD cord-010092-uftc8inx 11391 3 a a DT cord-010092-uftc8inx 11391 4 difference difference NN cord-010092-uftc8inx 11391 5 in in IN cord-010092-uftc8inx 11391 6 the the DT cord-010092-uftc8inx 11391 7 distribution distribution NN cord-010092-uftc8inx 11391 8 of of IN cord-010092-uftc8inx 11391 9 diseases disease NNS cord-010092-uftc8inx 11391 10 between between IN cord-010092-uftc8inx 11391 11 unexpected unexpected JJ cord-010092-uftc8inx 11391 12 antibody antibody NN cord-010092-uftc8inx 11391 13 positive positive JJ cord-010092-uftc8inx 11391 14 group group NN cord-010092-uftc8inx 11391 15 and and CC cord-010092-uftc8inx 11391 16 negative negative JJ cord-010092-uftc8inx 11391 17 group group NN cord-010092-uftc8inx 11391 18 . . . cord-010092-uftc8inx 11392 1 The the DT cord-010092-uftc8inx 11392 2 patients patient NNS cord-010092-uftc8inx 11392 3 with with IN cord-010092-uftc8inx 11392 4 liver liver NN cord-010092-uftc8inx 11392 5 cirrhosis cirrhosis NN cord-010092-uftc8inx 11392 6 were be VBD cord-010092-uftc8inx 11392 7 more more RBR cord-010092-uftc8inx 11392 8 frequent frequent JJ cord-010092-uftc8inx 11392 9 in in IN cord-010092-uftc8inx 11392 10 unexpected unexpected JJ cord-010092-uftc8inx 11392 11 antibody antibody NN cord-010092-uftc8inx 11392 12 positive positive JJ cord-010092-uftc8inx 11392 13 group group NN cord-010092-uftc8inx 11392 14 , , , cord-010092-uftc8inx 11392 15 suggesting suggest VBG cord-010092-uftc8inx 11392 16 that that IN cord-010092-uftc8inx 11392 17 extended extend VBN cord-010092-uftc8inx 11392 18 red red JJ cord-010092-uftc8inx 11392 19 blood blood NN cord-010092-uftc8inx 11392 20 cell cell NN cord-010092-uftc8inx 11392 21 matching matching NN cord-010092-uftc8inx 11392 22 would would MD cord-010092-uftc8inx 11392 23 be be VB cord-010092-uftc8inx 11392 24 considered consider VBN cord-010092-uftc8inx 11392 25 . . . cord-010092-uftc8inx 11393 1 Background background NN cord-010092-uftc8inx 11393 2 : : : cord-010092-uftc8inx 11394 1 In in IN cord-010092-uftc8inx 11394 2 hematological hematological JJ cord-010092-uftc8inx 11394 3 patients patient NNS cord-010092-uftc8inx 11394 4 with with IN cord-010092-uftc8inx 11394 5 multiple multiple JJ cord-010092-uftc8inx 11394 6 platelet platelet NN cord-010092-uftc8inx 11394 7 transfusions transfusion NNS cord-010092-uftc8inx 11394 8 ( ( -LRB- cord-010092-uftc8inx 11394 9 PC pc NN cord-010092-uftc8inx 11394 10 ) ) -RRB- cord-010092-uftc8inx 11394 11 often often RB cord-010092-uftc8inx 11394 12 develop develop VBP cord-010092-uftc8inx 11394 13 immune immune JJ cord-010092-uftc8inx 11394 14 response response NN cord-010092-uftc8inx 11394 15 to to IN cord-010092-uftc8inx 11394 16 human human JJ cord-010092-uftc8inx 11394 17 leukocyte leukocyte NN cord-010092-uftc8inx 11394 18 associated associate VBD cord-010092-uftc8inx 11394 19 antigens antigen NNS cord-010092-uftc8inx 11394 20 ( ( -LRB- cord-010092-uftc8inx 11394 21 HLA HLA NNP cord-010092-uftc8inx 11394 22 - - HYPH cord-010092-uftc8inx 11394 23 I I NNP cord-010092-uftc8inx 11394 24 ) ) -RRB- cord-010092-uftc8inx 11394 25 and and CC cord-010092-uftc8inx 11394 26 human human JJ cord-010092-uftc8inx 11394 27 platelet platelet NN cord-010092-uftc8inx 11394 28 - - HYPH cord-010092-uftc8inx 11394 29 specific specific JJ cord-010092-uftc8inx 11394 30 associated associate VBN cord-010092-uftc8inx 11394 31 antigens antigen NNS cord-010092-uftc8inx 11394 32 ( ( -LRB- cord-010092-uftc8inx 11394 33 HPA HPA NNP cord-010092-uftc8inx 11394 34 ) ) -RRB- cord-010092-uftc8inx 11394 35 . . . cord-010092-uftc8inx 11395 1 Besides besides RB cord-010092-uftc8inx 11395 2 , , , cord-010092-uftc8inx 11395 3 platelet platelet NN cord-010092-uftc8inx 11395 4 associated associate VBN cord-010092-uftc8inx 11395 5 immunoglobulins immunoglobulin NNS cord-010092-uftc8inx 11395 6 ( ( -LRB- cord-010092-uftc8inx 11395 7 PAIg PAIg NNS cord-010092-uftc8inx 11395 8 ) ) -RRB- cord-010092-uftc8inx 11395 9 and and CC cord-010092-uftc8inx 11395 10 complement complement VB cord-010092-uftc8inx 11395 11 components component NNS cord-010092-uftc8inx 11395 12 ( ( -LRB- cord-010092-uftc8inx 11395 13 PAC PAC NNP cord-010092-uftc8inx 11395 14 ) ) -RRB- cord-010092-uftc8inx 11395 15 are be VBP cord-010092-uftc8inx 11395 16 found find VBN cord-010092-uftc8inx 11395 17 on on IN cord-010092-uftc8inx 11395 18 platelet platelet NN cord-010092-uftc8inx 11395 19 . . . cord-010092-uftc8inx 11396 1 This this DT cord-010092-uftc8inx 11396 2 leads lead VBZ cord-010092-uftc8inx 11396 3 to to IN cord-010092-uftc8inx 11396 4 increased increase VBN cord-010092-uftc8inx 11396 5 platelet platelet NN cord-010092-uftc8inx 11396 6 destruction destruction NN cord-010092-uftc8inx 11396 7 and and CC cord-010092-uftc8inx 11396 8 development development NN cord-010092-uftc8inx 11396 9 of of IN cord-010092-uftc8inx 11396 10 refractoriness refractoriness NN cord-010092-uftc8inx 11396 11 to to IN cord-010092-uftc8inx 11396 12 transfusions transfusion NNS cord-010092-uftc8inx 11396 13 of of IN cord-010092-uftc8inx 11396 14 donors donor NNS cord-010092-uftc8inx 11396 15 ' ' POS cord-010092-uftc8inx 11396 16 platelets platelet NNS cord-010092-uftc8inx 11396 17 . . . cord-010092-uftc8inx 11397 1 Transfusion transfusion NN cord-010092-uftc8inx 11397 2 therapy therapy NN cord-010092-uftc8inx 11397 3 using use VBG cord-010092-uftc8inx 11397 4 an an DT cord-010092-uftc8inx 11397 5 individual individual JJ cord-010092-uftc8inx 11397 6 selection selection NN cord-010092-uftc8inx 11397 7 of of IN cord-010092-uftc8inx 11397 8 platelets platelet NNS cord-010092-uftc8inx 11397 9 and and CC cord-010092-uftc8inx 11397 10 plasmapheresis plasmapheresis NN cord-010092-uftc8inx 11397 11 , , , cord-010092-uftc8inx 11397 12 contribute contribute VBP cord-010092-uftc8inx 11397 13 , , , cord-010092-uftc8inx 11397 14 in in IN cord-010092-uftc8inx 11397 15 the the DT cord-010092-uftc8inx 11397 16 majority majority NN cord-010092-uftc8inx 11397 17 of of IN cord-010092-uftc8inx 11397 18 cases case NNS cord-010092-uftc8inx 11397 19 , , , cord-010092-uftc8inx 11397 20 to to IN cord-010092-uftc8inx 11397 21 the the DT cord-010092-uftc8inx 11397 22 realization realization NN cord-010092-uftc8inx 11397 23 of of IN cord-010092-uftc8inx 11397 24 efficient efficient JJ cord-010092-uftc8inx 11397 25 transfusion transfusion NN cord-010092-uftc8inx 11397 26 by by IN cord-010092-uftc8inx 11397 27 PC pc NN cord-010092-uftc8inx 11397 28 . . . cord-010092-uftc8inx 11398 1 But but CC cord-010092-uftc8inx 11398 2 , , , cord-010092-uftc8inx 11398 3 in in IN cord-010092-uftc8inx 11398 4 difficult difficult JJ cord-010092-uftc8inx 11398 5 cases case NNS cord-010092-uftc8inx 11398 6 , , , cord-010092-uftc8inx 11398 7 there there EX cord-010092-uftc8inx 11398 8 is be VBZ cord-010092-uftc8inx 11398 9 a a DT cord-010092-uftc8inx 11398 10 need need NN cord-010092-uftc8inx 11398 11 to to TO cord-010092-uftc8inx 11398 12 use use VB cord-010092-uftc8inx 11398 13 intravenous intravenous JJ cord-010092-uftc8inx 11398 14 immunoglobulin immunoglobulin NN cord-010092-uftc8inx 11398 15 , , , cord-010092-uftc8inx 11398 16 which which WDT cord-010092-uftc8inx 11398 17 may may MD cord-010092-uftc8inx 11398 18 promote promote VB cord-010092-uftc8inx 11398 19 the the DT cord-010092-uftc8inx 11398 20 efficient efficient JJ cord-010092-uftc8inx 11398 21 transfusion transfusion NN cord-010092-uftc8inx 11398 22 of of IN cord-010092-uftc8inx 11398 23 PC pc NN cord-010092-uftc8inx 11398 24 . . . cord-010092-uftc8inx 11399 1 Aims aim NNS cord-010092-uftc8inx 11399 2 : : : cord-010092-uftc8inx 11399 3 Evaluate evaluate VB cord-010092-uftc8inx 11399 4 the the DT cord-010092-uftc8inx 11399 5 algorithms algorithm NNS cord-010092-uftc8inx 11399 6 of of IN cord-010092-uftc8inx 11399 7 using use VBG cord-010092-uftc8inx 11399 8 the the DT cord-010092-uftc8inx 11399 9 complex complex JJ cord-010092-uftc8inx 11399 10 therapy therapy NN cord-010092-uftc8inx 11399 11 of of IN cord-010092-uftc8inx 11399 12 refractoriness refractoriness NN cord-010092-uftc8inx 11399 13 to to IN cord-010092-uftc8inx 11399 14 transfusions transfusion NNS cord-010092-uftc8inx 11399 15 of of IN cord-010092-uftc8inx 11399 16 donors donor NNS cord-010092-uftc8inx 11399 17 ' ' POS cord-010092-uftc8inx 11399 18 platelets platelet NNS cord-010092-uftc8inx 11399 19 with with IN cord-010092-uftc8inx 11399 20 additional additional JJ cord-010092-uftc8inx 11399 21 application application NN cord-010092-uftc8inx 11399 22 of of IN cord-010092-uftc8inx 11399 23 intravenous intravenous JJ cord-010092-uftc8inx 11399 24 immunoglobulin immunoglobulin NN cord-010092-uftc8inx 11399 25 ( ( -LRB- cord-010092-uftc8inx 11399 26 IVIG IVIG NNP cord-010092-uftc8inx 11399 27 ) ) -RRB- cord-010092-uftc8inx 11399 28 . . . cord-010092-uftc8inx 11400 1 Methods method NNS cord-010092-uftc8inx 11400 2 : : : cord-010092-uftc8inx 11401 1 In in IN cord-010092-uftc8inx 11401 2 2018 2018 CD cord-010092-uftc8inx 11401 3 there there EX cord-010092-uftc8inx 11401 4 were be VBD cord-010092-uftc8inx 11401 5 three three CD cord-010092-uftc8inx 11401 6 female female JJ cord-010092-uftc8inx 11401 7 patients patient NNS cord-010092-uftc8inx 11401 8 in in IN cord-010092-uftc8inx 11401 9 the the DT cord-010092-uftc8inx 11401 10 clinics clinic NNS cord-010092-uftc8inx 11401 11 of of IN cord-010092-uftc8inx 11401 12 the the DT cord-010092-uftc8inx 11401 13 centre centre NN cord-010092-uftc8inx 11401 14 for for IN cord-010092-uftc8inx 11401 15 observation observation NN cord-010092-uftc8inx 11401 16 , , , cord-010092-uftc8inx 11401 17 age age NN cord-010092-uftc8inx 11401 18 between between IN cord-010092-uftc8inx 11401 19 29 29 CD cord-010092-uftc8inx 11401 20 and and CC cord-010092-uftc8inx 11401 21 51 51 CD cord-010092-uftc8inx 11401 22 years year NNS cord-010092-uftc8inx 11402 1 ( ( -LRB- cord-010092-uftc8inx 11402 2 Me Me NNP cord-010092-uftc8inx 11402 3 = = VBZ cord-010092-uftc8inx 11402 4 39 39 CD cord-010092-uftc8inx 11402 5 ) ) -RRB- cord-010092-uftc8inx 11402 6 with with IN cord-010092-uftc8inx 11402 7 the the DT cord-010092-uftc8inx 11402 8 ineffectiveness ineffectiveness NN cord-010092-uftc8inx 11402 9 of of IN cord-010092-uftc8inx 11402 10 complex complex JJ cord-010092-uftc8inx 11402 11 therapy therapy NN cord-010092-uftc8inx 11402 12 for for IN cord-010092-uftc8inx 11402 13 overcoming overcome VBG cord-010092-uftc8inx 11402 14 refractoriness refractorines NNS cord-010092-uftc8inx 11402 15 to to IN cord-010092-uftc8inx 11402 16 transfusions transfusion NNS cord-010092-uftc8inx 11402 17 of of IN cord-010092-uftc8inx 11402 18 donors donor NNS cord-010092-uftc8inx 11402 19 ' ' POS cord-010092-uftc8inx 11402 20 platelets platelet NNS cord-010092-uftc8inx 11402 21 due due JJ cord-010092-uftc8inx 11402 22 to to IN cord-010092-uftc8inx 11402 23 selection selection NN cord-010092-uftc8inx 11402 24 and and CC cord-010092-uftc8inx 11402 25 plasmapheresis plasmapheresis NN cord-010092-uftc8inx 11402 26 . . . cord-010092-uftc8inx 11403 1 The the DT cord-010092-uftc8inx 11403 2 diagnoses diagnosis NNS cord-010092-uftc8inx 11403 3 were be VBD cord-010092-uftc8inx 11403 4 as as IN cord-010092-uftc8inx 11403 5 follows follow VBZ cord-010092-uftc8inx 11403 6 : : : cord-010092-uftc8inx 11403 7 aplastic aplastic JJ cord-010092-uftc8inx 11403 8 anaemia anaemia NN cord-010092-uftc8inx 11403 9 ( ( -LRB- cord-010092-uftc8inx 11403 10 AA)-2 AA)-2 NNP cord-010092-uftc8inx 11403 11 , , , cord-010092-uftc8inx 11403 12 acute acute JJ cord-010092-uftc8inx 11403 13 myeloid myeloid NN cord-010092-uftc8inx 11403 14 leukemia leukemia NN cord-010092-uftc8inx 11403 15 ( ( -LRB- cord-010092-uftc8inx 11403 16 AML)-1 aml)-1 NN cord-010092-uftc8inx 11403 17 . . . cord-010092-uftc8inx 11404 1 Individual individual JJ cord-010092-uftc8inx 11404 2 selection selection NN cord-010092-uftc8inx 11404 3 of of IN cord-010092-uftc8inx 11404 4 platelets platelet NNS cord-010092-uftc8inx 11404 5 was be VBD cord-010092-uftc8inx 11404 6 carried carry VBN cord-010092-uftc8inx 11404 7 out out RP cord-010092-uftc8inx 11404 8 by by IN cord-010092-uftc8inx 11404 9 the the DT cord-010092-uftc8inx 11404 10 adhesion adhesion NN cord-010092-uftc8inx 11404 11 method method NN cord-010092-uftc8inx 11404 12 on on IN cord-010092-uftc8inx 11404 13 the the DT cord-010092-uftc8inx 11404 14 solid solid JJ cord-010092-uftc8inx 11404 15 phase phase NN cord-010092-uftc8inx 11404 16 ( ( -LRB- cord-010092-uftc8inx 11404 17 Immucor Immucor NNP cord-010092-uftc8inx 11404 18 " " `` cord-010092-uftc8inx 11404 19 Galileo Galileo NNP cord-010092-uftc8inx 11404 20 Neo Neo NNP cord-010092-uftc8inx 11404 21 " " '' cord-010092-uftc8inx 11404 22 ) ) -RRB- cord-010092-uftc8inx 11404 23 . . . cord-010092-uftc8inx 11405 1 PAIg PAIg NNS cord-010092-uftc8inx 11405 2 and and CC cord-010092-uftc8inx 11405 3 PAC3/4 PAC3/4 NNP cord-010092-uftc8inx 11405 4 were be VBD cord-010092-uftc8inx 11405 5 evaluated evaluate VBN cord-010092-uftc8inx 11405 6 by by IN cord-010092-uftc8inx 11405 7 the the DT cord-010092-uftc8inx 11405 8 method method NN cord-010092-uftc8inx 11405 9 of of IN cord-010092-uftc8inx 11405 10 flow flow NN cord-010092-uftc8inx 11405 11 cytometry cytometry NN cord-010092-uftc8inx 11405 12 ( ( -LRB- cord-010092-uftc8inx 11405 13 BD BD NNP cord-010092-uftc8inx 11405 14 FACSCanto FACSCanto NNP cord-010092-uftc8inx 11405 15 II II NNP cord-010092-uftc8inx 11405 16 ) ) -RRB- cord-010092-uftc8inx 11405 17 by by IN cord-010092-uftc8inx 11405 18 the the DT cord-010092-uftc8inx 11405 19 method method NN cord-010092-uftc8inx 11405 20 of of IN cord-010092-uftc8inx 11405 21 double double JJ cord-010092-uftc8inx 11405 22 staining staining NN cord-010092-uftc8inx 11405 23 with with IN cord-010092-uftc8inx 11405 24 CD41a CD41a NNP cord-010092-uftc8inx 11405 25 . . . cord-010092-uftc8inx 11406 1 The the DT cord-010092-uftc8inx 11406 2 density density NN cord-010092-uftc8inx 11406 3 of of IN cord-010092-uftc8inx 11406 4 fixed fix VBN cord-010092-uftc8inx 11406 5 PAIg PAIg NNS cord-010092-uftc8inx 11406 6 , , , cord-010092-uftc8inx 11406 7 PAC PAC NNP cord-010092-uftc8inx 11406 8 was be VBD cord-010092-uftc8inx 11406 9 © © NNP cord-010092-uftc8inx 11406 10 2019 2019 CD cord-010092-uftc8inx 11407 1 The the DT cord-010092-uftc8inx 11407 2 Authors author NNS cord-010092-uftc8inx 11407 3 Vox Vox NNP cord-010092-uftc8inx 11407 4 Sanguinis Sanguinis NNP cord-010092-uftc8inx 11407 5 © © NN cord-010092-uftc8inx 11408 1 2019 2019 CD cord-010092-uftc8inx 11408 2 International International NNP cord-010092-uftc8inx 11408 3 Society Society NNP cord-010092-uftc8inx 11408 4 of of IN cord-010092-uftc8inx 11408 5 Blood Blood NNP cord-010092-uftc8inx 11408 6 Transfusion Transfusion NNP cord-010092-uftc8inx 11408 7 Vox Vox NNP cord-010092-uftc8inx 11408 8 Sanguinis Sanguinis NNP cord-010092-uftc8inx 11408 9 ( ( -LRB- cord-010092-uftc8inx 11408 10 2019 2019 CD cord-010092-uftc8inx 11408 11 ) ) -RRB- cord-010092-uftc8inx 11408 12 114 114 CD cord-010092-uftc8inx 11409 1 ( ( -LRB- cord-010092-uftc8inx 11409 2 Suppl Suppl NNP cord-010092-uftc8inx 11409 3 . . . cord-010092-uftc8inx 11410 1 1 1 LS cord-010092-uftc8inx 11410 2 ) ) -RRB- cord-010092-uftc8inx 11410 3 , , , cord-010092-uftc8inx 11410 4 5 5 CD cord-010092-uftc8inx 11410 5 - - SYM cord-010092-uftc8inx 11410 6 240 240 CD cord-010092-uftc8inx 11410 7 evaluated evaluate VBN cord-010092-uftc8inx 11410 8 by by IN cord-010092-uftc8inx 11410 9 the the DT cord-010092-uftc8inx 11410 10 Median Median NNP cord-010092-uftc8inx 11410 11 Fluorescence Fluorescence NNP cord-010092-uftc8inx 11410 12 Intensity Intensity NNP cord-010092-uftc8inx 11410 13 ( ( -LRB- cord-010092-uftc8inx 11410 14 MFI MFI NNP cord-010092-uftc8inx 11410 15 ) ) -RRB- cord-010092-uftc8inx 11410 16 . . . cord-010092-uftc8inx 11411 1 The the DT cord-010092-uftc8inx 11411 2 two two CD cord-010092-uftc8inx 11411 3 patients patient NNS cord-010092-uftc8inx 11411 4 with with IN cord-010092-uftc8inx 11411 5 AA AA NNP cord-010092-uftc8inx 11411 6 received receive VBD cord-010092-uftc8inx 11411 7 IVIG IVIG NNP cord-010092-uftc8inx 11411 8 - - HYPH cord-010092-uftc8inx 11411 9 IgG igg NN cord-010092-uftc8inx 11411 10 therapy therapy NN cord-010092-uftc8inx 11411 11 in in IN cord-010092-uftc8inx 11411 12 the the DT cord-010092-uftc8inx 11411 13 standard standard JJ cord-010092-uftc8inx 11411 14 dose dose NN cord-010092-uftc8inx 11411 15 0,4 0,4 CD cord-010092-uftc8inx 11411 16 g g NN cord-010092-uftc8inx 11411 17 / / SYM cord-010092-uftc8inx 11411 18 kg kg NN cord-010092-uftc8inx 11411 19 per per IN cord-010092-uftc8inx 11411 20 day day NN cord-010092-uftc8inx 11411 21 , , , cord-010092-uftc8inx 11411 22 for for IN cord-010092-uftc8inx 11411 23 3 3 CD cord-010092-uftc8inx 11411 24 days day NNS cord-010092-uftc8inx 11411 25 . . . cord-010092-uftc8inx 11412 1 One one CD cord-010092-uftc8inx 11412 2 patient patient NN cord-010092-uftc8inx 11412 3 with with IN cord-010092-uftc8inx 11412 4 AML AML NNP cord-010092-uftc8inx 11412 5 received receive VBD cord-010092-uftc8inx 11412 6 IVIG IVIG NNP cord-010092-uftc8inx 11412 7 - - : cord-010092-uftc8inx 11412 8 IgGAM iggam CD cord-010092-uftc8inx 11412 9 therapy therapy NN cord-010092-uftc8inx 11412 10 in in IN cord-010092-uftc8inx 11412 11 the the DT cord-010092-uftc8inx 11412 12 standard standard JJ cord-010092-uftc8inx 11412 13 dose dose NN cord-010092-uftc8inx 11412 14 5,0 5,0 CD cord-010092-uftc8inx 11412 15 ml ml NN cord-010092-uftc8inx 11412 16 / / SYM cord-010092-uftc8inx 11412 17 kg kg NNP cord-010092-uftc8inx 11412 18 / / SYM cord-010092-uftc8inx 11412 19 day day NN cord-010092-uftc8inx 11412 20 for for IN cord-010092-uftc8inx 11412 21 3 3 CD cord-010092-uftc8inx 11412 22 . . . cord-010092-uftc8inx 11413 1 Results result NNS cord-010092-uftc8inx 11413 2 : : : cord-010092-uftc8inx 11414 1 Under under IN cord-010092-uftc8inx 11414 2 pressure pressure NN cord-010092-uftc8inx 11414 3 of of IN cord-010092-uftc8inx 11414 4 the the DT cord-010092-uftc8inx 11414 5 complex complex JJ cord-010092-uftc8inx 11414 6 therapy therapy NN cord-010092-uftc8inx 11414 7 with with IN cord-010092-uftc8inx 11414 8 the the DT cord-010092-uftc8inx 11414 9 use use NN cord-010092-uftc8inx 11414 10 of of IN cord-010092-uftc8inx 11414 11 IVIG IVIG NNP cord-010092-uftc8inx 11414 12 in in IN cord-010092-uftc8inx 11414 13 the the DT cord-010092-uftc8inx 11414 14 standard standard JJ cord-010092-uftc8inx 11414 15 dose dose NN cord-010092-uftc8inx 11414 16 there there EX cord-010092-uftc8inx 11414 17 was be VBD cord-010092-uftc8inx 11414 18 are be VBP cord-010092-uftc8inx 11414 19 decrease decrease NN cord-010092-uftc8inx 11414 20 in in IN cord-010092-uftc8inx 11414 21 MFI MFI NNP cord-010092-uftc8inx 11414 22 over over IN cord-010092-uftc8inx 11414 23 time time NN cord-010092-uftc8inx 11414 24 in in IN cord-010092-uftc8inx 11414 25 the the DT cord-010092-uftc8inx 11414 26 case case NN cord-010092-uftc8inx 11414 27 of of IN cord-010092-uftc8inx 11414 28 two two CD cord-010092-uftc8inx 11414 29 patients patient NNS cord-010092-uftc8inx 11414 30 : : : cord-010092-uftc8inx 11415 1 AA-1 AA-1 NNP cord-010092-uftc8inx 11416 1 MFI MFI NNP cord-010092-uftc8inx 11416 2 - - HYPH cord-010092-uftc8inx 11416 3 PAIgG PAIgG NNP cord-010092-uftc8inx 11416 4 reduced reduce VBD cord-010092-uftc8inx 11416 5 from from IN cord-010092-uftc8inx 11416 6 926 926 CD cord-010092-uftc8inx 11416 7 to to TO cord-010092-uftc8inx 11416 8 65 65 CD cord-010092-uftc8inx 11416 9 ; ; : cord-010092-uftc8inx 11416 10 while while IN cord-010092-uftc8inx 11416 11 the the DT cord-010092-uftc8inx 11416 12 patient patient NN cord-010092-uftc8inx 11416 13 with with IN cord-010092-uftc8inx 11416 14 AML AML NNP cord-010092-uftc8inx 11416 15 : : : cord-010092-uftc8inx 11417 1 PAIgA PAIgA NNS cord-010092-uftc8inx 11417 2 reduced reduce VBN cord-010092-uftc8inx 11417 3 from from IN cord-010092-uftc8inx 11417 4 5506 5506 CD cord-010092-uftc8inx 11417 5 to to IN cord-010092-uftc8inx 11417 6 187 187 CD cord-010092-uftc8inx 11417 7 , , , cord-010092-uftc8inx 11417 8 and and CC cord-010092-uftc8inx 11417 9 PAIgM paigm NN cord-010092-uftc8inx 11417 10 from from IN cord-010092-uftc8inx 11417 11 1971 1971 CD cord-010092-uftc8inx 11417 12 to to IN cord-010092-uftc8inx 11417 13 302 302 CD cord-010092-uftc8inx 11417 14 , , , cord-010092-uftc8inx 11417 15 PAC3 PAC3 NNP cord-010092-uftc8inx 11417 16 from from IN cord-010092-uftc8inx 11417 17 691 691 CD cord-010092-uftc8inx 11417 18 to to IN cord-010092-uftc8inx 11417 19 31 31 CD cord-010092-uftc8inx 11417 20 , , , cord-010092-uftc8inx 11417 21 PAC4 PAC4 NNP cord-010092-uftc8inx 11417 22 from from IN cord-010092-uftc8inx 11417 23 404 404 CD cord-010092-uftc8inx 11417 24 to to IN cord-010092-uftc8inx 11417 25 103 103 CD cord-010092-uftc8inx 11417 26 . . . cord-010092-uftc8inx 11418 1 The the DT cord-010092-uftc8inx 11418 2 patient patient NN cord-010092-uftc8inx 11418 3 with with IN cord-010092-uftc8inx 11418 4 AA-2 AA-2 NNP cord-010092-uftc8inx 11418 5 over over IN cord-010092-uftc8inx 11418 6 time time NN cord-010092-uftc8inx 11418 7 , , , cord-010092-uftc8inx 11418 8 regardless regardless RB cord-010092-uftc8inx 11418 9 of of IN cord-010092-uftc8inx 11418 10 the the DT cord-010092-uftc8inx 11418 11 treatment treatment NN cord-010092-uftc8inx 11418 12 , , , cord-010092-uftc8inx 11418 13 there there EX cord-010092-uftc8inx 11418 14 was be VBD cord-010092-uftc8inx 11418 15 an an DT cord-010092-uftc8inx 11418 16 increase increase NN cord-010092-uftc8inx 11418 17 of of IN cord-010092-uftc8inx 11418 18 MFI MFI NNP cord-010092-uftc8inx 11418 19 , , , cord-010092-uftc8inx 11418 20 but but CC cord-010092-uftc8inx 11418 21 the the DT cord-010092-uftc8inx 11418 22 effect effect NN cord-010092-uftc8inx 11418 23 of of IN cord-010092-uftc8inx 11418 24 PC pc NN cord-010092-uftc8inx 11418 25 transfusions transfusion NNS cord-010092-uftc8inx 11418 26 was be VBD cord-010092-uftc8inx 11418 27 achieved achieve VBN cord-010092-uftc8inx 11418 28 under under IN cord-010092-uftc8inx 11418 29 pressure pressure NN cord-010092-uftc8inx 11418 30 of of IN cord-010092-uftc8inx 11418 31 complex complex JJ cord-010092-uftc8inx 11418 32 therapy therapy NN cord-010092-uftc8inx 11418 33 . . . cord-010092-uftc8inx 11419 1 Under under IN cord-010092-uftc8inx 11419 2 pressure pressure NN cord-010092-uftc8inx 11419 3 of of IN cord-010092-uftc8inx 11419 4 complex complex JJ cord-010092-uftc8inx 11419 5 therapy therapy NN cord-010092-uftc8inx 11419 6 all all PDT cord-010092-uftc8inx 11419 7 the the DT cord-010092-uftc8inx 11419 8 3 3 CD cord-010092-uftc8inx 11419 9 patients patient NNS cord-010092-uftc8inx 11419 10 also also RB cord-010092-uftc8inx 11419 11 reduced reduce VBD cord-010092-uftc8inx 11419 12 the the DT cord-010092-uftc8inx 11419 13 frequency frequency NN cord-010092-uftc8inx 11419 14 of of IN cord-010092-uftc8inx 11419 15 reaction reaction NN cord-010092-uftc8inx 11419 16 of of IN cord-010092-uftc8inx 11419 17 alloantibodies alloantibody NNS cord-010092-uftc8inx 11419 18 when when WRB cord-010092-uftc8inx 11419 19 resorting resort VBG cord-010092-uftc8inx 11419 20 to to IN cord-010092-uftc8inx 11419 21 an an DT cord-010092-uftc8inx 11419 22 individual individual JJ cord-010092-uftc8inx 11419 23 selection selection NN cord-010092-uftc8inx 11419 24 and and CC cord-010092-uftc8inx 11419 25 increasing increase VBG cord-010092-uftc8inx 11419 26 the the DT cord-010092-uftc8inx 11419 27 frequency frequency NN cord-010092-uftc8inx 11419 28 of of IN cord-010092-uftc8inx 11419 29 compatible compatible JJ cord-010092-uftc8inx 11419 30 couples couple NNS cord-010092-uftc8inx 11419 31 " " '' cord-010092-uftc8inx 11419 32 donor donor NN cord-010092-uftc8inx 11419 33 - - HYPH cord-010092-uftc8inx 11419 34 recipient recipient NN cord-010092-uftc8inx 11419 35 " " '' cord-010092-uftc8inx 11419 36 . . . cord-010092-uftc8inx 11420 1 Summary Summary NNP cord-010092-uftc8inx 11420 2 / / SYM cord-010092-uftc8inx 11420 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 11420 4 : : : cord-010092-uftc8inx 11421 1 Delivery delivery NN cord-010092-uftc8inx 11421 2 of of IN cord-010092-uftc8inx 11421 3 complex complex JJ cord-010092-uftc8inx 11421 4 therapy therapy NN cord-010092-uftc8inx 11421 5 and and CC cord-010092-uftc8inx 11421 6 the the DT cord-010092-uftc8inx 11421 7 additional additional JJ cord-010092-uftc8inx 11421 8 application application NN cord-010092-uftc8inx 11421 9 of of IN cord-010092-uftc8inx 11421 10 IVIG IVIG NNP cord-010092-uftc8inx 11421 11 enables enable VBZ cord-010092-uftc8inx 11421 12 an an DT cord-010092-uftc8inx 11421 13 adequate adequate JJ cord-010092-uftc8inx 11421 14 transfusion transfusion NN cord-010092-uftc8inx 11421 15 therapy therapy NN cord-010092-uftc8inx 11421 16 of of IN cord-010092-uftc8inx 11421 17 PC PC NNP cord-010092-uftc8inx 11421 18 , , , cord-010092-uftc8inx 11421 19 neutralize neutralize VB cord-010092-uftc8inx 11421 20 hemorrhagic hemorrhagic JJ cord-010092-uftc8inx 11421 21 syndrome syndrome NN cord-010092-uftc8inx 11421 22 and and CC cord-010092-uftc8inx 11421 23 continue continue VB cord-010092-uftc8inx 11421 24 the the DT cord-010092-uftc8inx 11421 25 treatment treatment NN cord-010092-uftc8inx 11421 26 of of IN cord-010092-uftc8inx 11421 27 the the DT cord-010092-uftc8inx 11421 28 main main JJ cord-010092-uftc8inx 11421 29 disease disease NN cord-010092-uftc8inx 11421 30 . . . cord-010092-uftc8inx 11422 1 Detection detection NN cord-010092-uftc8inx 11422 2 and and CC cord-010092-uftc8inx 11422 3 monitoring monitoring NN cord-010092-uftc8inx 11422 4 of of IN cord-010092-uftc8inx 11422 5 PAIg PAIg NNS cord-010092-uftc8inx 11422 6 / / SYM cord-010092-uftc8inx 11422 7 PAC PAC NNP cord-010092-uftc8inx 11422 8 during during IN cord-010092-uftc8inx 11422 9 the the DT cord-010092-uftc8inx 11422 10 development development NN cord-010092-uftc8inx 11422 11 of of IN cord-010092-uftc8inx 11422 12 refractoriness refractoriness NN cord-010092-uftc8inx 11422 13 to to IN cord-010092-uftc8inx 11422 14 transfusions transfusion NNS cord-010092-uftc8inx 11422 15 of of IN cord-010092-uftc8inx 11422 16 donors donor NNS cord-010092-uftc8inx 11422 17 ' ' POS cord-010092-uftc8inx 11422 18 platelets platelet NNS cord-010092-uftc8inx 11422 19 are be VBP cord-010092-uftc8inx 11422 20 additional additional JJ cord-010092-uftc8inx 11422 21 markers marker NNS cord-010092-uftc8inx 11422 22 for for IN cord-010092-uftc8inx 11422 23 prescription prescription NN cord-010092-uftc8inx 11422 24 of of IN cord-010092-uftc8inx 11422 25 IVIG IVIG NNP cord-010092-uftc8inx 11422 26 therapy therapy NN cord-010092-uftc8inx 11422 27 . . . cord-010092-uftc8inx 11423 1 Anaesthesia Anaesthesia NNP cord-010092-uftc8inx 11423 2 , , , cord-010092-uftc8inx 11423 3 Tan Tan NNP cord-010092-uftc8inx 11423 4 Tong Tong NNP cord-010092-uftc8inx 11423 5 Seng Seng NNP cord-010092-uftc8inx 11423 6 Hospital Hospital NNP cord-010092-uftc8inx 11423 7 , , , cord-010092-uftc8inx 11423 8 Singapore Singapore NNP cord-010092-uftc8inx 11423 9 , , , cord-010092-uftc8inx 11423 10 Singapore Singapore NNP cord-010092-uftc8inx 11423 11 Background Background NNP cord-010092-uftc8inx 11423 12 : : : cord-010092-uftc8inx 11424 1 Blood blood NN cord-010092-uftc8inx 11424 2 transfusion transfusion NN cord-010092-uftc8inx 11424 3 is be VBZ cord-010092-uftc8inx 11424 4 quite quite RB cord-010092-uftc8inx 11424 5 prevalent prevalent JJ cord-010092-uftc8inx 11424 6 in in IN cord-010092-uftc8inx 11424 7 paediatric paediatric JJ cord-010092-uftc8inx 11424 8 cardiac cardiac JJ cord-010092-uftc8inx 11424 9 surgical surgical JJ cord-010092-uftc8inx 11424 10 procedures procedure NNS cord-010092-uftc8inx 11424 11 . . . cord-010092-uftc8inx 11425 1 We -PRON- PRP cord-010092-uftc8inx 11425 2 hypothesized hypothesize VBD cord-010092-uftc8inx 11425 3 that that IN cord-010092-uftc8inx 11425 4 the the DT cord-010092-uftc8inx 11425 5 routine routine JJ cord-010092-uftc8inx 11425 6 use use NN cord-010092-uftc8inx 11425 7 of of IN cord-010092-uftc8inx 11425 8 rotational rotational JJ cord-010092-uftc8inx 11425 9 thromboelastography thromboelastography NN cord-010092-uftc8inx 11425 10 ( ( -LRB- cord-010092-uftc8inx 11425 11 ROTEM ROTEM NNP cord-010092-uftc8inx 11425 12 ) ) -RRB- cord-010092-uftc8inx 11425 13 to to TO cord-010092-uftc8inx 11425 14 guide guide VB cord-010092-uftc8inx 11425 15 transfusion transfusion NN cord-010092-uftc8inx 11425 16 decisions decision NNS cord-010092-uftc8inx 11425 17 would would MD cord-010092-uftc8inx 11425 18 reduce reduce VB cord-010092-uftc8inx 11425 19 the the DT cord-010092-uftc8inx 11425 20 overall overall JJ cord-010092-uftc8inx 11425 21 proportion proportion NN cord-010092-uftc8inx 11425 22 of of IN cord-010092-uftc8inx 11425 23 patients patient NNS cord-010092-uftc8inx 11425 24 receiving receive VBG cord-010092-uftc8inx 11425 25 transfusions transfusion NNS cord-010092-uftc8inx 11425 26 in in IN cord-010092-uftc8inx 11425 27 paediatric paediatric JJ cord-010092-uftc8inx 11425 28 cardiac cardiac JJ cord-010092-uftc8inx 11425 29 surgery surgery NN cord-010092-uftc8inx 11425 30 Aims Aims NNPS cord-010092-uftc8inx 11425 31 : : : cord-010092-uftc8inx 11425 32 The the DT cord-010092-uftc8inx 11425 33 aim aim NN cord-010092-uftc8inx 11425 34 of of IN cord-010092-uftc8inx 11425 35 the the DT cord-010092-uftc8inx 11425 36 study study NN cord-010092-uftc8inx 11425 37 was be VBD cord-010092-uftc8inx 11425 38 to to TO cord-010092-uftc8inx 11425 39 find find VB cord-010092-uftc8inx 11425 40 if if IN cord-010092-uftc8inx 11425 41 the the DT cord-010092-uftc8inx 11425 42 use use NN cord-010092-uftc8inx 11425 43 of of IN cord-010092-uftc8inx 11425 44 blood blood NN cord-010092-uftc8inx 11425 45 and and CC cord-010092-uftc8inx 11425 46 blood blood NN cord-010092-uftc8inx 11425 47 products product NNS cord-010092-uftc8inx 11425 48 in in IN cord-010092-uftc8inx 11425 49 pediatric pediatric JJ cord-010092-uftc8inx 11425 50 cardiac cardiac JJ cord-010092-uftc8inx 11425 51 surgical surgical JJ cord-010092-uftc8inx 11425 52 cases case NNS cord-010092-uftc8inx 11425 53 in in IN cord-010092-uftc8inx 11425 54 a a DT cord-010092-uftc8inx 11425 55 single single JJ cord-010092-uftc8inx 11425 56 centre centre NN cord-010092-uftc8inx 11425 57 is be VBZ cord-010092-uftc8inx 11425 58 affected affect VBN cord-010092-uftc8inx 11425 59 due due IN cord-010092-uftc8inx 11425 60 to to IN cord-010092-uftc8inx 11425 61 ROTEM ROTEM NNP cord-010092-uftc8inx 11425 62 . . . cord-010092-uftc8inx 11426 1 Methods method NNS cord-010092-uftc8inx 11426 2 : : : cord-010092-uftc8inx 11427 1 Sixty sixty CD cord-010092-uftc8inx 11427 2 paediatric paediatric JJ cord-010092-uftc8inx 11427 3 cardiac cardiac JJ cord-010092-uftc8inx 11427 4 surgical surgical JJ cord-010092-uftc8inx 11427 5 patients patient NNS cord-010092-uftc8inx 11427 6 undergoing undergo VBG cord-010092-uftc8inx 11427 7 CPB CPB NNP cord-010092-uftc8inx 11427 8 were be VBD cord-010092-uftc8inx 11427 9 included include VBN cord-010092-uftc8inx 11427 10 in in IN cord-010092-uftc8inx 11427 11 this this DT cord-010092-uftc8inx 11427 12 study study NN cord-010092-uftc8inx 11427 13 . . . cord-010092-uftc8inx 11428 1 Thirty thirty CD cord-010092-uftc8inx 11428 2 patients patient NNS cord-010092-uftc8inx 11428 3 ( ( -LRB- cord-010092-uftc8inx 11428 4 study study NN cord-010092-uftc8inx 11428 5 group group NN cord-010092-uftc8inx 11428 6 ) ) -RRB- cord-010092-uftc8inx 11428 7 were be VBD cord-010092-uftc8inx 11428 8 prospectively prospectively RB cord-010092-uftc8inx 11428 9 included include VBN cord-010092-uftc8inx 11428 10 and and CC cord-010092-uftc8inx 11428 11 compared compare VBN cord-010092-uftc8inx 11428 12 with with IN cord-010092-uftc8inx 11428 13 thirty thirty CD cord-010092-uftc8inx 11428 14 procedure procedure NN cord-010092-uftc8inx 11428 15 and and CC cord-010092-uftc8inx 11428 16 age age NN cord-010092-uftc8inx 11428 17 - - HYPH cord-010092-uftc8inx 11428 18 matched match VBN cord-010092-uftc8inx 11428 19 control control NN cord-010092-uftc8inx 11428 20 patients patient NNS cord-010092-uftc8inx 11428 21 ( ( -LRB- cord-010092-uftc8inx 11428 22 control control NNP cord-010092-uftc8inx 11428 23 group group NN cord-010092-uftc8inx 11428 24 ) ) -RRB- cord-010092-uftc8inx 11428 25 . . . cord-010092-uftc8inx 11429 1 In in IN cord-010092-uftc8inx 11429 2 the the DT cord-010092-uftc8inx 11429 3 study study NN cord-010092-uftc8inx 11429 4 group group NN cord-010092-uftc8inx 11429 5 , , , cord-010092-uftc8inx 11429 6 ROTEM ROTEM NNP cord-010092-uftc8inx 11429 7 , , , cord-010092-uftc8inx 11429 8 performed perform VBN cord-010092-uftc8inx 11429 9 during during IN cord-010092-uftc8inx 11429 10 CPB CPB NNP cord-010092-uftc8inx 11429 11 guided guide VBD cord-010092-uftc8inx 11429 12 intraoperative intraoperative JJ cord-010092-uftc8inx 11429 13 transfusions transfusion NNS cord-010092-uftc8inx 11429 14 . . . cord-010092-uftc8inx 11430 1 Perioperative perioperative JJ cord-010092-uftc8inx 11430 2 transfusions transfusion NNS cord-010092-uftc8inx 11430 3 of of IN cord-010092-uftc8inx 11430 4 blood blood NN cord-010092-uftc8inx 11430 5 and and CC cord-010092-uftc8inx 11430 6 blood blood NN cord-010092-uftc8inx 11430 7 products product NNS cord-010092-uftc8inx 11430 8 , , , cord-010092-uftc8inx 11430 9 postoperative postoperative JJ cord-010092-uftc8inx 11430 10 blood blood NN cord-010092-uftc8inx 11430 11 loss loss NN cord-010092-uftc8inx 11430 12 and and CC cord-010092-uftc8inx 11430 13 hemoglobin hemoglobin NN cord-010092-uftc8inx 11430 14 levels level NNS cord-010092-uftc8inx 11430 15 were be VBD cord-010092-uftc8inx 11430 16 compared compare VBN cord-010092-uftc8inx 11430 17 between between IN cord-010092-uftc8inx 11430 18 the the DT cord-010092-uftc8inx 11430 19 two two CD cord-010092-uftc8inx 11430 20 groups group NNS cord-010092-uftc8inx 11430 21 . . . cord-010092-uftc8inx 11431 1 Results result NNS cord-010092-uftc8inx 11431 2 : : : cord-010092-uftc8inx 11432 1 The the DT cord-010092-uftc8inx 11432 2 patients patient NNS cord-010092-uftc8inx 11432 3 in in IN cord-010092-uftc8inx 11432 4 the the DT cord-010092-uftc8inx 11432 5 control control NN cord-010092-uftc8inx 11432 6 group group NN cord-010092-uftc8inx 11432 7 received receive VBD cord-010092-uftc8inx 11432 8 fewer few JJR cord-010092-uftc8inx 11432 9 transfusions transfusion NNS cord-010092-uftc8inx 11432 10 of of IN cord-010092-uftc8inx 11432 11 packed pack VBN cord-010092-uftc8inx 11432 12 cells cell NNS cord-010092-uftc8inx 11432 13 ( ( -LRB- cord-010092-uftc8inx 11432 14 60 60 CD cord-010092-uftc8inx 11432 15 % % NN cord-010092-uftc8inx 11432 16 vs vs IN cord-010092-uftc8inx 11432 17 78 78 CD cord-010092-uftc8inx 11432 18 % % NN cord-010092-uftc8inx 11432 19 ) ) -RRB- cord-010092-uftc8inx 11432 20 and and CC cord-010092-uftc8inx 11432 21 fresh fresh JJ cord-010092-uftc8inx 11432 22 frozen frozen JJ cord-010092-uftc8inx 11432 23 plasma plasma NN cord-010092-uftc8inx 11432 24 ( ( -LRB- cord-010092-uftc8inx 11432 25 36 36 CD cord-010092-uftc8inx 11432 26 % % NN cord-010092-uftc8inx 11432 27 vs vs IN cord-010092-uftc8inx 11432 28 84 84 CD cord-010092-uftc8inx 11432 29 % % NN cord-010092-uftc8inx 11432 30 P p NN cord-010092-uftc8inx 11432 31 < < XX cord-010092-uftc8inx 11432 32 o.oo1 o.oo1 NNP cord-010092-uftc8inx 11432 33 ) ) -RRB- cord-010092-uftc8inx 11432 34 . . . cord-010092-uftc8inx 11433 1 More More JJR cord-010092-uftc8inx 11433 2 patients patient NNS cord-010092-uftc8inx 11433 3 in in IN cord-010092-uftc8inx 11433 4 the the DT cord-010092-uftc8inx 11433 5 study study NN cord-010092-uftc8inx 11433 6 group group NN cord-010092-uftc8inx 11433 7 received receive VBD cord-010092-uftc8inx 11433 8 platelets platelet NNS cord-010092-uftc8inx 11433 9 ( ( -LRB- cord-010092-uftc8inx 11433 10 72 72 CD cord-010092-uftc8inx 11433 11 % % NN cord-010092-uftc8inx 11433 12 vs vs IN cord-010092-uftc8inx 11433 13 60 60 CD cord-010092-uftc8inx 11433 14 % % NN cord-010092-uftc8inx 11433 15 ) ) -RRB- cord-010092-uftc8inx 11433 16 and and CC cord-010092-uftc8inx 11433 17 cryoprecipitate cryoprecipitate NNP cord-010092-uftc8inx 11433 18 ( ( -LRB- cord-010092-uftc8inx 11433 19 50 50 CD cord-010092-uftc8inx 11433 20 % % NN cord-010092-uftc8inx 11433 21 vs vs IN cord-010092-uftc8inx 11433 22 36 36 CD cord-010092-uftc8inx 11433 23 % % NN cord-010092-uftc8inx 11433 24 ) ) -RRB- cord-010092-uftc8inx 11433 25 . . . cord-010092-uftc8inx 11434 1 The the DT cord-010092-uftc8inx 11434 2 postoperative postoperative JJ cord-010092-uftc8inx 11434 3 blood blood NN cord-010092-uftc8inx 11434 4 loss loss NN cord-010092-uftc8inx 11434 5 was be VBD cord-010092-uftc8inx 11434 6 lower low JJR cord-010092-uftc8inx 11434 7 in in IN cord-010092-uftc8inx 11434 8 study study NN cord-010092-uftc8inx 11434 9 group group NN cord-010092-uftc8inx 11434 10 compared compare VBN cord-010092-uftc8inx 11434 11 to to IN cord-010092-uftc8inx 11434 12 the the DT cord-010092-uftc8inx 11434 13 control control NN cord-010092-uftc8inx 11434 14 group group NN cord-010092-uftc8inx 11434 15 . . . cord-010092-uftc8inx 11435 1 The the DT cord-010092-uftc8inx 11435 2 postoperative postoperative JJ cord-010092-uftc8inx 11435 3 hemoglobin hemoglobin NN cord-010092-uftc8inx 11435 4 did do VBD cord-010092-uftc8inx 11435 5 not not RB cord-010092-uftc8inx 11435 6 differ differ VB cord-010092-uftc8inx 11435 7 between between IN cord-010092-uftc8inx 11435 8 the the DT cord-010092-uftc8inx 11435 9 two two CD cord-010092-uftc8inx 11435 10 groups group NNS cord-010092-uftc8inx 11435 11 . . . cord-010092-uftc8inx 11436 1 Summary Summary NNP cord-010092-uftc8inx 11436 2 / / SYM cord-010092-uftc8inx 11436 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 11436 4 : : : cord-010092-uftc8inx 11437 1 The the DT cord-010092-uftc8inx 11437 2 results result NNS cord-010092-uftc8inx 11437 3 suggest suggest VBP cord-010092-uftc8inx 11437 4 that that IN cord-010092-uftc8inx 11437 5 the the DT cord-010092-uftc8inx 11437 6 routine routine JJ cord-010092-uftc8inx 11437 7 use use NN cord-010092-uftc8inx 11437 8 of of IN cord-010092-uftc8inx 11437 9 ROTEM ROTEM NNP cord-010092-uftc8inx 11437 10 in in IN cord-010092-uftc8inx 11437 11 paediatric paediatric JJ cord-010092-uftc8inx 11437 12 cardiac cardiac JJ cord-010092-uftc8inx 11437 13 surgery surgery NN cord-010092-uftc8inx 11437 14 to to TO cord-010092-uftc8inx 11437 15 guide guide VB cord-010092-uftc8inx 11437 16 transfusions transfusion NNS cord-010092-uftc8inx 11437 17 is be VBZ cord-010092-uftc8inx 11437 18 associated associate VBN cord-010092-uftc8inx 11437 19 with with IN cord-010092-uftc8inx 11437 20 reduced reduced JJ cord-010092-uftc8inx 11437 21 proportions proportion NNS cord-010092-uftc8inx 11437 22 of of IN cord-010092-uftc8inx 11437 23 patients patient NNS cord-010092-uftc8inx 11437 24 receiving receive VBG cord-010092-uftc8inx 11437 25 transfusions transfusion NNS cord-010092-uftc8inx 11437 26 and and CC cord-010092-uftc8inx 11437 27 is be VBZ cord-010092-uftc8inx 11437 28 evidence evidence NN cord-010092-uftc8inx 11437 29 based base VBN cord-010092-uftc8inx 11437 30 practice practice NN cord-010092-uftc8inx 11437 31 . . . cord-010092-uftc8inx 11438 1 Abstract Abstract NNP cord-010092-uftc8inx 11438 2 withdrawn withdraw VBN cord-010092-uftc8inx 11438 3 . . . cord-010092-uftc8inx 11439 1 Abstract Abstract NNP cord-010092-uftc8inx 11439 2 withdrawn withdraw VBN cord-010092-uftc8inx 11439 3 . . . cord-010092-uftc8inx 11440 1 Abstract Abstract NNP cord-010092-uftc8inx 11440 2 withdrawn withdraw VBN cord-010092-uftc8inx 11440 3 . . . cord-010092-uftc8inx 11441 1 Background background NN cord-010092-uftc8inx 11441 2 : : : cord-010092-uftc8inx 11442 1 Mycoplasma mycoplasma NN cord-010092-uftc8inx 11442 2 pneumonia pneumonia NN cord-010092-uftc8inx 11442 3 ( ( -LRB- cord-010092-uftc8inx 11442 4 MP MP NNP cord-010092-uftc8inx 11442 5 ) ) -RRB- cord-010092-uftc8inx 11442 6 infection infection NN cord-010092-uftc8inx 11442 7 has have VBZ cord-010092-uftc8inx 11442 8 often often RB cord-010092-uftc8inx 11442 9 been be VBN cord-010092-uftc8inx 11442 10 implicated implicate VBN cord-010092-uftc8inx 11442 11 in in IN cord-010092-uftc8inx 11442 12 respiratory respiratory JJ cord-010092-uftc8inx 11442 13 tract tract NN cord-010092-uftc8inx 11442 14 infections infection NNS cord-010092-uftc8inx 11442 15 . . . cord-010092-uftc8inx 11443 1 Although although IN cord-010092-uftc8inx 11443 2 this this DT cord-010092-uftc8inx 11443 3 agent agent NN cord-010092-uftc8inx 11443 4 has have VBZ cord-010092-uftc8inx 11443 5 also also RB cord-010092-uftc8inx 11443 6 been be VBN cord-010092-uftc8inx 11443 7 associated associate VBN cord-010092-uftc8inx 11443 8 with with IN cord-010092-uftc8inx 11443 9 other other JJ cord-010092-uftc8inx 11443 10 non non JJ cord-010092-uftc8inx 11443 11 - - JJ cord-010092-uftc8inx 11443 12 respiratory respiratory JJ cord-010092-uftc8inx 11443 13 diseases disease NNS cord-010092-uftc8inx 11443 14 , , , cord-010092-uftc8inx 11443 15 hemolytic hemolytic JJ cord-010092-uftc8inx 11443 16 anemia anemia NN cord-010092-uftc8inx 11443 17 is be VBZ cord-010092-uftc8inx 11443 18 the the DT cord-010092-uftc8inx 11443 19 most most RBS cord-010092-uftc8inx 11443 20 common common JJ cord-010092-uftc8inx 11443 21 hematologic hematologic JJ cord-010092-uftc8inx 11443 22 complication complication NN cord-010092-uftc8inx 11443 23 of of IN cord-010092-uftc8inx 11443 24 MP MP NNP cord-010092-uftc8inx 11443 25 infection infection NN cord-010092-uftc8inx 11443 26 . . . cord-010092-uftc8inx 11444 1 Episodes episode NNS cord-010092-uftc8inx 11444 2 of of IN cord-010092-uftc8inx 11444 3 sudden sudden JJ cord-010092-uftc8inx 11444 4 onset onset NN cord-010092-uftc8inx 11444 5 of of IN cord-010092-uftc8inx 11444 6 severe severe JJ cord-010092-uftc8inx 11444 7 anemia anemia NN cord-010092-uftc8inx 11444 8 are be VBP cord-010092-uftc8inx 11444 9 rarely rarely RB cord-010092-uftc8inx 11444 10 seen see VBN cord-010092-uftc8inx 11444 11 in in IN cord-010092-uftc8inx 11444 12 beta beta NN cord-010092-uftc8inx 11444 13 thalassemia thalassemia NN cord-010092-uftc8inx 11444 14 . . . cord-010092-uftc8inx 11445 1 We -PRON- PRP cord-010092-uftc8inx 11445 2 report report VBP cord-010092-uftc8inx 11445 3 a a DT cord-010092-uftc8inx 11445 4 33-years 33-years CD cord-010092-uftc8inx 11445 5 - - HYPH cord-010092-uftc8inx 11445 6 old old JJ cord-010092-uftc8inx 11445 7 female female NN cord-010092-uftc8inx 11445 8 with with IN cord-010092-uftc8inx 11445 9 beta beta NN cord-010092-uftc8inx 11445 10 thalassemia thalassemia NN cord-010092-uftc8inx 11445 11 major major NN cord-010092-uftc8inx 11445 12 who who WP cord-010092-uftc8inx 11445 13 was be VBD cord-010092-uftc8inx 11445 14 diagnosed diagnose VBN cord-010092-uftc8inx 11445 15 to to TO cord-010092-uftc8inx 11445 16 have have VB cord-010092-uftc8inx 11445 17 severe severe JJ cord-010092-uftc8inx 11445 18 anemia anemia NN cord-010092-uftc8inx 11445 19 secondary secondary JJ cord-010092-uftc8inx 11445 20 to to IN cord-010092-uftc8inx 11445 21 autoimmune autoimmune JJ cord-010092-uftc8inx 11445 22 hemolytic hemolytic JJ cord-010092-uftc8inx 11445 23 anemia anemia NN cord-010092-uftc8inx 11445 24 induced induce VBN cord-010092-uftc8inx 11445 25 from from IN cord-010092-uftc8inx 11445 26 MP MP NNP cord-010092-uftc8inx 11445 27 infection infection NN cord-010092-uftc8inx 11445 28 Aims aim VBZ cord-010092-uftc8inx 11445 29 : : : cord-010092-uftc8inx 11445 30 To to TO cord-010092-uftc8inx 11445 31 report report VB cord-010092-uftc8inx 11445 32 a a DT cord-010092-uftc8inx 11445 33 case case NN cord-010092-uftc8inx 11445 34 of of IN cord-010092-uftc8inx 11445 35 patient patient NN cord-010092-uftc8inx 11445 36 with with IN cord-010092-uftc8inx 11445 37 beta beta NN cord-010092-uftc8inx 11445 38 thalassemia thalassemia NN cord-010092-uftc8inx 11445 39 major major NN cord-010092-uftc8inx 11445 40 who who WP cord-010092-uftc8inx 11445 41 was be VBD cord-010092-uftc8inx 11445 42 diagnosed diagnose VBN cord-010092-uftc8inx 11445 43 to to TO cord-010092-uftc8inx 11445 44 have have VB cord-010092-uftc8inx 11445 45 severe severe JJ cord-010092-uftc8inx 11445 46 anemia anemia NN cord-010092-uftc8inx 11445 47 secondary secondary JJ cord-010092-uftc8inx 11445 48 to to IN cord-010092-uftc8inx 11445 49 autoimmune autoimmune JJ cord-010092-uftc8inx 11445 50 hemolytic hemolytic JJ cord-010092-uftc8inx 11445 51 anemia anemia NN cord-010092-uftc8inx 11445 52 induced induce VBN cord-010092-uftc8inx 11445 53 from from IN cord-010092-uftc8inx 11445 54 MP MP NNP cord-010092-uftc8inx 11445 55 infection infection NN cord-010092-uftc8inx 11445 56 and and CC cord-010092-uftc8inx 11445 57 how how WRB cord-010092-uftc8inx 11445 58 it -PRON- PRP cord-010092-uftc8inx 11445 59 was be VBD cord-010092-uftc8inx 11445 60 managed manage VBN cord-010092-uftc8inx 11445 61 with with IN cord-010092-uftc8inx 11445 62 minimal minimal JJ cord-010092-uftc8inx 11445 63 transfusion transfusion NN cord-010092-uftc8inx 11445 64 . . . cord-010092-uftc8inx 11446 1 Methods method NNS cord-010092-uftc8inx 11446 2 : : : cord-010092-uftc8inx 11447 1 A a DT cord-010092-uftc8inx 11447 2 33-year 33-year JJ cord-010092-uftc8inx 11447 3 - - HYPH cord-010092-uftc8inx 11447 4 old old JJ cord-010092-uftc8inx 11447 5 female female JJ cord-010092-uftc8inx 11447 6 case case NN cord-010092-uftc8inx 11447 7 of of IN cord-010092-uftc8inx 11447 8 beta beta NN cord-010092-uftc8inx 11447 9 thalassemia thalassemia NN cord-010092-uftc8inx 11447 10 major major NN cord-010092-uftc8inx 11447 11 who who WP cord-010092-uftc8inx 11447 12 developed develop VBD cord-010092-uftc8inx 11447 13 autoimmune autoimmune JJ cord-010092-uftc8inx 11447 14 hemolytic hemolytic JJ cord-010092-uftc8inx 11447 15 anemia anemia NN cord-010092-uftc8inx 11447 16 following follow VBG cord-010092-uftc8inx 11447 17 Mycoplasma Mycoplasma NNP cord-010092-uftc8inx 11447 18 infection infection NN cord-010092-uftc8inx 11447 19 . . . cord-010092-uftc8inx 11448 1 The the DT cord-010092-uftc8inx 11448 2 patient patient NN cord-010092-uftc8inx 11448 3 is be VBZ cord-010092-uftc8inx 11448 4 on on IN cord-010092-uftc8inx 11448 5 monthly monthly JJ cord-010092-uftc8inx 11448 6 blood blood NN cord-010092-uftc8inx 11448 7 transfusion transfusion NN cord-010092-uftc8inx 11448 8 since since IN cord-010092-uftc8inx 11448 9 the the DT cord-010092-uftc8inx 11448 10 age age NN cord-010092-uftc8inx 11448 11 of of IN cord-010092-uftc8inx 11448 12 3 3 CD cord-010092-uftc8inx 11448 13 years year NNS cord-010092-uftc8inx 11448 14 at at IN cord-010092-uftc8inx 11448 15 Dubai Dubai NNP cord-010092-uftc8inx 11448 16 Thalassemia Thalassemia NNP cord-010092-uftc8inx 11448 17 Center Center NNP cord-010092-uftc8inx 11448 18 . . . cord-010092-uftc8inx 11449 1 She -PRON- PRP cord-010092-uftc8inx 11449 2 was be VBD cord-010092-uftc8inx 11449 3 admitted admit VBN cord-010092-uftc8inx 11449 4 to to IN cord-010092-uftc8inx 11449 5 the the DT cord-010092-uftc8inx 11449 6 hospital hospital NN cord-010092-uftc8inx 11449 7 with with IN cord-010092-uftc8inx 11449 8 5 5 CD cord-010092-uftc8inx 11449 9 days day NNS cord-010092-uftc8inx 11449 10 history history NN cord-010092-uftc8inx 11449 11 of of IN cord-010092-uftc8inx 11449 12 dizziness dizziness NN cord-010092-uftc8inx 11449 13 , , , cord-010092-uftc8inx 11449 14 severe severe JJ cord-010092-uftc8inx 11449 15 low low JJ cord-010092-uftc8inx 11449 16 back back NN cord-010092-uftc8inx 11449 17 and and CC cord-010092-uftc8inx 11449 18 joint joint JJ cord-010092-uftc8inx 11449 19 pain pain NN cord-010092-uftc8inx 11449 20 and and CC cord-010092-uftc8inx 11449 21 her -PRON- PRP$ cord-010092-uftc8inx 11449 22 travel travel NN cord-010092-uftc8inx 11449 23 history history NN cord-010092-uftc8inx 11450 1 indicated indicate VBD cord-010092-uftc8inx 11450 2 a a DT cord-010092-uftc8inx 11450 3 four four CD cord-010092-uftc8inx 11450 4 - - HYPH cord-010092-uftc8inx 11450 5 week week NN cord-010092-uftc8inx 11450 6 visit visit NN cord-010092-uftc8inx 11450 7 to to IN cord-010092-uftc8inx 11450 8 Pakistan Pakistan NNP cord-010092-uftc8inx 11450 9 . . . cord-010092-uftc8inx 11451 1 Initial initial JJ cord-010092-uftc8inx 11451 2 investigations investigation NNS cord-010092-uftc8inx 11451 3 showed show VBD cord-010092-uftc8inx 11451 4 a a DT cord-010092-uftc8inx 11451 5 hemoglobin hemoglobin NN cord-010092-uftc8inx 11451 6 level level NN cord-010092-uftc8inx 11451 7 of of IN cord-010092-uftc8inx 11451 8 7.8 7.8 CD cord-010092-uftc8inx 11451 9 g g NN cord-010092-uftc8inx 11451 10 / / SYM cord-010092-uftc8inx 11451 11 dL dl NN cord-010092-uftc8inx 11451 12 the the DT cord-010092-uftc8inx 11451 13 direct direct JJ cord-010092-uftc8inx 11451 14 and and CC cord-010092-uftc8inx 11451 15 indirect indirect JJ cord-010092-uftc8inx 11451 16 coombs coombs NNP cord-010092-uftc8inx 11451 17 test test NN cord-010092-uftc8inx 11451 18 were be VBD cord-010092-uftc8inx 11451 19 positive positive JJ cord-010092-uftc8inx 11451 20 . . . cord-010092-uftc8inx 11452 1 Patient Patient NNP cord-010092-uftc8inx 11452 2 was be VBD cord-010092-uftc8inx 11452 3 transfused transfuse VBN cord-010092-uftc8inx 11452 4 with with IN cord-010092-uftc8inx 11452 5 two two CD cord-010092-uftc8inx 11452 6 units unit NNS cord-010092-uftc8inx 11452 7 leuko leuko NN cord-010092-uftc8inx 11452 8 - - HYPH cord-010092-uftc8inx 11452 9 depleted deplete VBN cord-010092-uftc8inx 11452 10 compatible compatible JJ cord-010092-uftc8inx 11452 11 PRBC PRBC NNP cord-010092-uftc8inx 11452 12 ( ( -LRB- cord-010092-uftc8inx 11452 13 O o UH cord-010092-uftc8inx 11452 14 , , , cord-010092-uftc8inx 11452 15 Rh Rh NNP cord-010092-uftc8inx 11452 16 + + CC cord-010092-uftc8inx 11452 17 , , , cord-010092-uftc8inx 11452 18 negative negative JJ cord-010092-uftc8inx 11452 19 for for IN cord-010092-uftc8inx 11452 20 E E NNP cord-010092-uftc8inx 11452 21 and and CC cord-010092-uftc8inx 11452 22 Kell Kell NNP cord-010092-uftc8inx 11452 23 antigens antigen NNS cord-010092-uftc8inx 11452 24 . . . cord-010092-uftc8inx 11452 25 ) ) -RRB- cord-010092-uftc8inx 11452 26 and and CC cord-010092-uftc8inx 11452 27 discharged discharge VBN cord-010092-uftc8inx 11452 28 next next JJ cord-010092-uftc8inx 11452 29 day day NN cord-010092-uftc8inx 11452 30 . . . cord-010092-uftc8inx 11453 1 Three three CD cord-010092-uftc8inx 11453 2 weeks week NNS cord-010092-uftc8inx 11453 3 later later RB cord-010092-uftc8inx 11453 4 , , , cord-010092-uftc8inx 11453 5 the the DT cord-010092-uftc8inx 11453 6 patient patient NN cord-010092-uftc8inx 11453 7 was be VBD cord-010092-uftc8inx 11453 8 still still RB cord-010092-uftc8inx 11453 9 with with IN cord-010092-uftc8inx 11453 10 lower low JJR cord-010092-uftc8inx 11453 11 limbs limb NNS cord-010092-uftc8inx 11453 12 pain pain NN cord-010092-uftc8inx 11453 13 and and CC cord-010092-uftc8inx 11453 14 the the DT cord-010092-uftc8inx 11453 15 hemoglobin hemoglobin NN cord-010092-uftc8inx 11453 16 was be VBD cord-010092-uftc8inx 11453 17 8.5 8.5 CD cord-010092-uftc8inx 11453 18 g g NN cord-010092-uftc8inx 11453 19 / / SYM cord-010092-uftc8inx 11453 20 dl dl NN cord-010092-uftc8inx 11453 21 with with IN cord-010092-uftc8inx 11453 22 a a DT cord-010092-uftc8inx 11453 23 positive positive JJ cord-010092-uftc8inx 11453 24 DAT dat NN cord-010092-uftc8inx 11453 25 with with IN cord-010092-uftc8inx 11453 26 both both CC cord-010092-uftc8inx 11453 27 IgG+4 igg+4 JJ cord-010092-uftc8inx 11453 28 and and CC cord-010092-uftc8inx 11453 29 C3 c3 NN cord-010092-uftc8inx 11453 30 + + SYM cord-010092-uftc8inx 11453 31 4 4 CD cord-010092-uftc8inx 11453 32 , , , cord-010092-uftc8inx 11453 33 patient patient JJ cord-010092-uftc8inx 11453 34 was be VBD cord-010092-uftc8inx 11453 35 not not RB cord-010092-uftc8inx 11453 36 transfused transfuse VBN cord-010092-uftc8inx 11453 37 as as IN cord-010092-uftc8inx 11453 38 it -PRON- PRP cord-010092-uftc8inx 11453 39 was be VBD cord-010092-uftc8inx 11453 40 difficult difficult JJ cord-010092-uftc8inx 11453 41 to to TO cord-010092-uftc8inx 11453 42 find find VB cord-010092-uftc8inx 11453 43 matching matching JJ cord-010092-uftc8inx 11453 44 blood blood NN cord-010092-uftc8inx 11453 45 ; ; : cord-010092-uftc8inx 11453 46 therefore therefore RB cord-010092-uftc8inx 11453 47 she -PRON- PRP cord-010092-uftc8inx 11453 48 was be VBD cord-010092-uftc8inx 11453 49 given give VBN cord-010092-uftc8inx 11453 50 one one CD cord-010092-uftc8inx 11453 51 week week NN cord-010092-uftc8inx 11453 52 follow follow VB cord-010092-uftc8inx 11453 53 up up RP cord-010092-uftc8inx 11453 54 . . . cord-010092-uftc8inx 11454 1 Four four CD cord-010092-uftc8inx 11454 2 days day NNS cord-010092-uftc8inx 11454 3 later later RB cord-010092-uftc8inx 11454 4 , , , cord-010092-uftc8inx 11454 5 patient patient NN cord-010092-uftc8inx 11454 6 reported report VBD cord-010092-uftc8inx 11454 7 to to IN cord-010092-uftc8inx 11454 8 the the DT cord-010092-uftc8inx 11454 9 center center NN cord-010092-uftc8inx 11454 10 with with IN cord-010092-uftc8inx 11454 11 fever fever NN cord-010092-uftc8inx 11454 12 , , , cord-010092-uftc8inx 11454 13 generalized generalize VBN cord-010092-uftc8inx 11454 14 body body NN cord-010092-uftc8inx 11454 15 pain pain NN cord-010092-uftc8inx 11454 16 and and CC cord-010092-uftc8inx 11454 17 fatigue fatigue NN cord-010092-uftc8inx 11454 18 . . . cord-010092-uftc8inx 11455 1 She -PRON- PRP cord-010092-uftc8inx 11455 2 had have VBD cord-010092-uftc8inx 11455 3 significant significant JJ cord-010092-uftc8inx 11455 4 drop drop NN cord-010092-uftc8inx 11455 5 in in IN cord-010092-uftc8inx 11455 6 hemoglobin hemoglobin NN cord-010092-uftc8inx 11455 7 5.6 5.6 CD cord-010092-uftc8inx 11455 8 g g NN cord-010092-uftc8inx 11455 9 / / SYM cord-010092-uftc8inx 11455 10 dl dl NNP cord-010092-uftc8inx 11455 11 , , , cord-010092-uftc8inx 11455 12 MCV MCV NNP cord-010092-uftc8inx 11455 13 85.0 85.0 CD cord-010092-uftc8inx 11455 14 , , , cord-010092-uftc8inx 11455 15 Platelets platelet NNS cord-010092-uftc8inx 11455 16 count count VBP cord-010092-uftc8inx 11455 17 216000 216000 CD cord-010092-uftc8inx 11455 18 , , , cord-010092-uftc8inx 11455 19 CRP CRP NNP cord-010092-uftc8inx 11455 20 3.6 3.6 CD cord-010092-uftc8inx 11455 21 , , , cord-010092-uftc8inx 11455 22 Retic Retic NNP cord-010092-uftc8inx 11455 23 count count NN cord-010092-uftc8inx 11455 24 2.18 2.18 CD cord-010092-uftc8inx 11455 25 , , , cord-010092-uftc8inx 11455 26 Blood blood NN cord-010092-uftc8inx 11455 27 culture culture NN cord-010092-uftc8inx 11456 1 no no DT cord-010092-uftc8inx 11456 2 growth growth NN cord-010092-uftc8inx 11456 3 , , , cord-010092-uftc8inx 11456 4 total total VBP cord-010092-uftc8inx 11456 5 bilirubin bilirubin NN cord-010092-uftc8inx 11456 6 1.5 1.5 CD cord-010092-uftc8inx 11457 1 , , , cord-010092-uftc8inx 11457 2 Malaria Malaria NNP cord-010092-uftc8inx 11457 3 parasite parasite NN cord-010092-uftc8inx 11457 4 smear smear NN cord-010092-uftc8inx 11457 5 was be VBD cord-010092-uftc8inx 11457 6 negative negative JJ cord-010092-uftc8inx 11457 7 , , , cord-010092-uftc8inx 11457 8 urine urine NN cord-010092-uftc8inx 11457 9 culture culture NN cord-010092-uftc8inx 11457 10 and and CC cord-010092-uftc8inx 11457 11 microscopy microscopy NNS cord-010092-uftc8inx 11457 12 were be VBD cord-010092-uftc8inx 11457 13 normal normal JJ cord-010092-uftc8inx 11457 14 . . . cord-010092-uftc8inx 11458 1 Mycoplasma mycoplasma NN cord-010092-uftc8inx 11458 2 pneumonia pneumonia NN cord-010092-uftc8inx 11458 3 antibody antibody NN cord-010092-uftc8inx 11458 4 showed show VBD cord-010092-uftc8inx 11458 5 positive positive JJ cord-010092-uftc8inx 11458 6 with with IN cord-010092-uftc8inx 11458 7 IgG IgG NNP cord-010092-uftc8inx 11458 8 57.1 57.1 CD cord-010092-uftc8inx 11458 9 and and CC cord-010092-uftc8inx 11458 10 IgM IgM NNP cord-010092-uftc8inx 11458 11 21.3 21.3 CD cord-010092-uftc8inx 11458 12 , , , cord-010092-uftc8inx 11458 13 she -PRON- PRP cord-010092-uftc8inx 11458 14 was be VBD cord-010092-uftc8inx 11458 15 started start VBN cord-010092-uftc8inx 11458 16 on on IN cord-010092-uftc8inx 11458 17 Azithromycin Azithromycin NNP cord-010092-uftc8inx 11458 18 for for IN cord-010092-uftc8inx 11458 19 5 5 CD cord-010092-uftc8inx 11458 20 days day NNS cord-010092-uftc8inx 11458 21 and and CC cord-010092-uftc8inx 11458 22 received receive VBD cord-010092-uftc8inx 11458 23 2 2 CD cord-010092-uftc8inx 11458 24 units unit NNS cord-010092-uftc8inx 11458 25 PRBC PRBC NNP cord-010092-uftc8inx 11458 26 least least JJS cord-010092-uftc8inx 11458 27 incompatible incompatible JJ cord-010092-uftc8inx 11458 28 leuko leuko NN cord-010092-uftc8inx 11458 29 - - HYPH cord-010092-uftc8inx 11458 30 depleted deplete VBN cord-010092-uftc8inx 11458 31 ( ( -LRB- cord-010092-uftc8inx 11458 32 O o UH cord-010092-uftc8inx 11458 33 , , , cord-010092-uftc8inx 11458 34 Rh Rh NNP cord-010092-uftc8inx 11458 35 + + CC cord-010092-uftc8inx 11458 36 , , , cord-010092-uftc8inx 11458 37 negative negative JJ cord-010092-uftc8inx 11458 38 for for IN cord-010092-uftc8inx 11458 39 E E NNP cord-010092-uftc8inx 11458 40 and and CC cord-010092-uftc8inx 11458 41 Kell Kell NNP cord-010092-uftc8inx 11458 42 antigens antigen NNS cord-010092-uftc8inx 11458 43 . . . cord-010092-uftc8inx 11458 44 ) ) -RRB- cord-010092-uftc8inx 11458 45 . . . cord-010092-uftc8inx 11459 1 After after IN cord-010092-uftc8inx 11459 2 which which WDT cord-010092-uftc8inx 11459 3 her -PRON- PRP$ cord-010092-uftc8inx 11459 4 hemoglobin hemoglobin NN cord-010092-uftc8inx 11459 5 increased increase VBD cord-010092-uftc8inx 11459 6 to to IN cord-010092-uftc8inx 11459 7 9.3 9.3 CD cord-010092-uftc8inx 11459 8 g g NN cord-010092-uftc8inx 11459 9 / / SYM cord-010092-uftc8inx 11459 10 dL. dl. NN cord-010092-uftc8inx 11460 1 She -PRON- PRP cord-010092-uftc8inx 11460 2 did do VBD cord-010092-uftc8inx 11460 3 not not RB cord-010092-uftc8inx 11460 4 show show VB cord-010092-uftc8inx 11460 5 any any DT cord-010092-uftc8inx 11460 6 improvement improvement NN cord-010092-uftc8inx 11460 7 in in IN cord-010092-uftc8inx 11460 8 her -PRON- PRP$ cord-010092-uftc8inx 11460 9 condition condition NN cord-010092-uftc8inx 11460 10 over over IN cord-010092-uftc8inx 11460 11 the the DT cord-010092-uftc8inx 11460 12 following follow VBG cord-010092-uftc8inx 11460 13 2 2 CD cord-010092-uftc8inx 11460 14 weeks week NNS cord-010092-uftc8inx 11460 15 and and CC cord-010092-uftc8inx 11460 16 repeat repeat VB cord-010092-uftc8inx 11460 17 Mycoplasma Mycoplasma NNP cord-010092-uftc8inx 11460 18 pneumonia pneumonia NN cord-010092-uftc8inx 11460 19 antibody antibody NN cord-010092-uftc8inx 11460 20 showed show VBD cord-010092-uftc8inx 11460 21 an an DT cord-010092-uftc8inx 11460 22 increased increase VBN cord-010092-uftc8inx 11460 23 titer titer NN cord-010092-uftc8inx 11460 24 , , , cord-010092-uftc8inx 11460 25 which which WDT cord-010092-uftc8inx 11460 26 denoted denote VBD cord-010092-uftc8inx 11460 27 resistance resistance NN cord-010092-uftc8inx 11460 28 to to IN cord-010092-uftc8inx 11460 29 Azithromycin Azithromycin NNP cord-010092-uftc8inx 11460 30 ; ; : cord-010092-uftc8inx 11460 31 hence hence RB cord-010092-uftc8inx 11460 32 , , , cord-010092-uftc8inx 11460 33 we -PRON- PRP cord-010092-uftc8inx 11460 34 started start VBD cord-010092-uftc8inx 11460 35 her -PRON- PRP cord-010092-uftc8inx 11460 36 with with IN cord-010092-uftc8inx 11460 37 second second JJ cord-010092-uftc8inx 11460 38 line line NN cord-010092-uftc8inx 11460 39 of of IN cord-010092-uftc8inx 11460 40 treatment treatment NN cord-010092-uftc8inx 11460 41 Levofloxacin Levofloxacin NNP cord-010092-uftc8inx 11460 42 for for IN cord-010092-uftc8inx 11460 43 10 10 CD cord-010092-uftc8inx 11460 44 days day NNS cord-010092-uftc8inx 11460 45 . . . cord-010092-uftc8inx 11461 1 Screening screen VBG cord-010092-uftc8inx 11461 2 for for IN cord-010092-uftc8inx 11461 3 collagen collagen NN cord-010092-uftc8inx 11461 4 disease disease NN cord-010092-uftc8inx 11461 5 were be VBD cord-010092-uftc8inx 11461 6 all all DT cord-010092-uftc8inx 11461 7 negative negative JJ cord-010092-uftc8inx 11461 8 apart apart RB cord-010092-uftc8inx 11461 9 from from IN cord-010092-uftc8inx 11461 10 high high JJ cord-010092-uftc8inx 11461 11 ESR ESR NNP cord-010092-uftc8inx 11461 12 of of IN cord-010092-uftc8inx 11461 13 130 130 CD cord-010092-uftc8inx 11461 14 mm mm NNP cord-010092-uftc8inx 11461 15 / / SYM cord-010092-uftc8inx 11461 16 hr hr NN cord-010092-uftc8inx 11461 17 . . . cord-010092-uftc8inx 11462 1 Patient Patient NNP cord-010092-uftc8inx 11462 2 remained remain VBD cord-010092-uftc8inx 11462 3 afebrile afebrile JJ cord-010092-uftc8inx 11462 4 and and CC cord-010092-uftc8inx 11462 5 transfused transfuse VBN cord-010092-uftc8inx 11462 6 with with IN cord-010092-uftc8inx 11462 7 least least JJS cord-010092-uftc8inx 11462 8 incompatible incompatible JJ cord-010092-uftc8inx 11462 9 available available JJ cord-010092-uftc8inx 11462 10 blood blood NN cord-010092-uftc8inx 11462 11 , , , cord-010092-uftc8inx 11462 12 post post NN cord-010092-uftc8inx 11462 13 transfusion transfusion NN cord-010092-uftc8inx 11462 14 Hb Hb NNP cord-010092-uftc8inx 11462 15 was be VBD cord-010092-uftc8inx 11462 16 11.8 11.8 CD cord-010092-uftc8inx 11462 17 g g NN cord-010092-uftc8inx 11462 18 / / SYM cord-010092-uftc8inx 11462 19 dl dl NN cord-010092-uftc8inx 11462 20 . . . cord-010092-uftc8inx 11463 1 Three three CD cord-010092-uftc8inx 11463 2 weeks week NNS cord-010092-uftc8inx 11463 3 later later RB cord-010092-uftc8inx 11463 4 , , , cord-010092-uftc8inx 11463 5 during during IN cord-010092-uftc8inx 11463 6 her -PRON- PRP$ cord-010092-uftc8inx 11463 7 routine routine JJ cord-010092-uftc8inx 11463 8 follow follow VB cord-010092-uftc8inx 11463 9 up up RP cord-010092-uftc8inx 11463 10 , , , cord-010092-uftc8inx 11463 11 she -PRON- PRP cord-010092-uftc8inx 11463 12 was be VBD cord-010092-uftc8inx 11463 13 doing do VBG cord-010092-uftc8inx 11463 14 well well RB cord-010092-uftc8inx 11463 15 with with IN cord-010092-uftc8inx 11463 16 ESR ESR NNP cord-010092-uftc8inx 11463 17 dropping drop VBG cord-010092-uftc8inx 11463 18 to to IN cord-010092-uftc8inx 11464 1 85 85 CD cord-010092-uftc8inx 11464 2 mm mm NNP cord-010092-uftc8inx 11464 3 / / SYM cord-010092-uftc8inx 11464 4 hr hr NN cord-010092-uftc8inx 11464 5 and and CC cord-010092-uftc8inx 11464 6 hemoglobin hemoglobin NN cord-010092-uftc8inx 11464 7 10.2 10.2 CD cord-010092-uftc8inx 11464 8 g g NNP cord-010092-uftc8inx 11464 9 / / SYM cord-010092-uftc8inx 11464 10 dl dl NNP cord-010092-uftc8inx 11464 11 , , , cord-010092-uftc8inx 11464 12 which which WDT cord-010092-uftc8inx 11464 13 indicated indicate VBD cord-010092-uftc8inx 11464 14 gradual gradual JJ cord-010092-uftc8inx 11464 15 settling settling NN cord-010092-uftc8inx 11464 16 of of IN cord-010092-uftc8inx 11464 17 hemolysis hemolysis NN cord-010092-uftc8inx 11464 18 , , , cord-010092-uftc8inx 11464 19 although although IN cord-010092-uftc8inx 11464 20 the the DT cord-010092-uftc8inx 11464 21 last last JJ cord-010092-uftc8inx 11464 22 DAT DAT NNP cord-010092-uftc8inx 11464 23 remained remain VBD cord-010092-uftc8inx 11464 24 positive positive JJ cord-010092-uftc8inx 11464 25 . . . cord-010092-uftc8inx 11465 1 Subsequent subsequent JJ cord-010092-uftc8inx 11465 2 visits visit NNS cord-010092-uftc8inx 11465 3 showed show VBD cord-010092-uftc8inx 11465 4 Hb Hb NNP cord-010092-uftc8inx 11465 5 drop drop NN cord-010092-uftc8inx 11465 6 of of IN cord-010092-uftc8inx 11465 7 1.2 1.2 CD cord-010092-uftc8inx 11465 8 g g NN cord-010092-uftc8inx 11465 9 / / SYM cord-010092-uftc8inx 11465 10 dl dl NN cord-010092-uftc8inx 11465 11 / / SYM cord-010092-uftc8inx 11465 12 week week NN cord-010092-uftc8inx 11465 13 which which WDT cord-010092-uftc8inx 11465 14 is be VBZ cord-010092-uftc8inx 11465 15 acceptable acceptable JJ cord-010092-uftc8inx 11465 16 for for IN cord-010092-uftc8inx 11465 17 transfusion transfusion NN cord-010092-uftc8inx 11465 18 dependant dependant JJ cord-010092-uftc8inx 11465 19 thalassemia thalassemia NN cord-010092-uftc8inx 11465 20 . . . cord-010092-uftc8inx 11466 1 Results result NNS cord-010092-uftc8inx 11466 2 : : : cord-010092-uftc8inx 11467 1 With with IN cord-010092-uftc8inx 11467 2 conservative conservative JJ cord-010092-uftc8inx 11467 3 management management NN cord-010092-uftc8inx 11467 4 patient patient NN cord-010092-uftc8inx 11467 5 condition condition NN cord-010092-uftc8inx 11467 6 improved improve VBD cord-010092-uftc8inx 11467 7 . . . cord-010092-uftc8inx 11468 1 Summary Summary NNP cord-010092-uftc8inx 11468 2 / / SYM cord-010092-uftc8inx 11468 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 11468 4 : : : cord-010092-uftc8inx 11469 1 Hemolytic hemolytic JJ cord-010092-uftc8inx 11469 2 anemia anemia NN cord-010092-uftc8inx 11469 3 associated associate VBN cord-010092-uftc8inx 11469 4 with with IN cord-010092-uftc8inx 11469 5 Mycoplasma Mycoplasma NNP cord-010092-uftc8inx 11469 6 pneumonia pneumonia NN cord-010092-uftc8inx 11469 7 is be VBZ cord-010092-uftc8inx 11469 8 usually usually RB cord-010092-uftc8inx 11469 9 self self NN cord-010092-uftc8inx 11469 10 - - HYPH cord-010092-uftc8inx 11469 11 limited limit VBN cord-010092-uftc8inx 11469 12 and and CC cord-010092-uftc8inx 11469 13 resolves resolve VBZ cord-010092-uftc8inx 11469 14 spontaneously spontaneously RB cord-010092-uftc8inx 11469 15 after after IN cord-010092-uftc8inx 11469 16 mycoplasma mycoplasma NN cord-010092-uftc8inx 11469 17 infection infection NN cord-010092-uftc8inx 11469 18 elimination elimination NN cord-010092-uftc8inx 11469 19 . . . cord-010092-uftc8inx 11470 1 Packed packed JJ cord-010092-uftc8inx 11470 2 red red JJ cord-010092-uftc8inx 11470 3 cell cell NN cord-010092-uftc8inx 11470 4 transfusion transfusion NN cord-010092-uftc8inx 11470 5 in in IN cord-010092-uftc8inx 11470 6 transfusion transfusion NN cord-010092-uftc8inx 11470 7 dependent dependent JJ cord-010092-uftc8inx 11470 8 patient patient NN cord-010092-uftc8inx 11470 9 may may MD cord-010092-uftc8inx 11470 10 be be VB cord-010092-uftc8inx 11470 11 troublesome troublesome JJ cord-010092-uftc8inx 11470 12 and and CC cord-010092-uftc8inx 11470 13 can can MD cord-010092-uftc8inx 11470 14 aggravate aggravate VB cord-010092-uftc8inx 11470 15 the the DT cord-010092-uftc8inx 11470 16 condition condition NN cord-010092-uftc8inx 11470 17 ; ; : cord-010092-uftc8inx 11470 18 therefore therefore RB cord-010092-uftc8inx 11470 19 it -PRON- PRP cord-010092-uftc8inx 11470 20 should should MD cord-010092-uftc8inx 11470 21 be be VB cord-010092-uftc8inx 11470 22 utilized utilize VBN cord-010092-uftc8inx 11470 23 and and CC cord-010092-uftc8inx 11470 24 limited limit VBN cord-010092-uftc8inx 11470 25 to to IN cord-010092-uftc8inx 11470 26 significant significant JJ cord-010092-uftc8inx 11470 27 symptomatic symptomatic JJ cord-010092-uftc8inx 11470 28 anaemia anaemia NN cord-010092-uftc8inx 11470 29 Background background NN cord-010092-uftc8inx 11470 30 : : : cord-010092-uftc8inx 11470 31 Early early JJ cord-010092-uftc8inx 11470 32 plasma plasma NN cord-010092-uftc8inx 11470 33 transfusion transfusion NN cord-010092-uftc8inx 11470 34 in in IN cord-010092-uftc8inx 11470 35 women woman NNS cord-010092-uftc8inx 11470 36 with with IN cord-010092-uftc8inx 11470 37 severe severe JJ cord-010092-uftc8inx 11470 38 postpartum postpartum NN cord-010092-uftc8inx 11470 39 hemorrhage hemorrhage NN cord-010092-uftc8inx 11470 40 is be VBZ cord-010092-uftc8inx 11470 41 often often RB cord-010092-uftc8inx 11470 42 instituted institute VBN cord-010092-uftc8inx 11470 43 to to TO cord-010092-uftc8inx 11470 44 prevent prevent VB cord-010092-uftc8inx 11470 45 and and CC cord-010092-uftc8inx 11470 46 treat treat VB cord-010092-uftc8inx 11470 47 coagulopathy coagulopathy NN cord-010092-uftc8inx 11470 48 , , , cord-010092-uftc8inx 11470 49 but but CC cord-010092-uftc8inx 11470 50 whether whether IN cord-010092-uftc8inx 11470 51 maternal maternal JJ cord-010092-uftc8inx 11470 52 outcomes outcome NNS cord-010092-uftc8inx 11470 53 improve improve VBP cord-010092-uftc8inx 11470 54 with with IN cord-010092-uftc8inx 11470 55 this this DT cord-010092-uftc8inx 11470 56 treatment treatment NN cord-010092-uftc8inx 11470 57 is be VBZ cord-010092-uftc8inx 11470 58 unclear unclear JJ cord-010092-uftc8inx 11470 59 . . . cord-010092-uftc8inx 11471 1 Aims aim VBZ cord-010092-uftc8inx 11471 2 : : : cord-010092-uftc8inx 11471 3 To to TO cord-010092-uftc8inx 11471 4 quantify quantify VB cord-010092-uftc8inx 11471 5 the the DT cord-010092-uftc8inx 11471 6 association association NN cord-010092-uftc8inx 11471 7 of of IN cord-010092-uftc8inx 11471 8 plasma plasma NNP cord-010092-uftc8inx 11471 9 transfusion transfusion NN cord-010092-uftc8inx 11471 10 within within IN cord-010092-uftc8inx 11471 11 the the DT cord-010092-uftc8inx 11471 12 first first JJ cord-010092-uftc8inx 11471 13 60 60 CD cord-010092-uftc8inx 11471 14 min min NN cord-010092-uftc8inx 11471 15 after after IN cord-010092-uftc8inx 11471 16 diagnosing diagnose VBG cord-010092-uftc8inx 11471 17 persistent persistent JJ cord-010092-uftc8inx 11471 18 postpartum postpartum NN cord-010092-uftc8inx 11471 19 hemorrhage hemorrhage NN cord-010092-uftc8inx 11471 20 and and CC cord-010092-uftc8inx 11471 21 adverse adverse JJ cord-010092-uftc8inx 11471 22 maternal maternal JJ cord-010092-uftc8inx 11471 23 outcome outcome NN cord-010092-uftc8inx 11471 24 . . . cord-010092-uftc8inx 11472 1 Methods method NNS cord-010092-uftc8inx 11472 2 : : : cord-010092-uftc8inx 11472 3 We -PRON- PRP cord-010092-uftc8inx 11472 4 performed perform VBD cord-010092-uftc8inx 11472 5 a a DT cord-010092-uftc8inx 11472 6 retrospective retrospective JJ cord-010092-uftc8inx 11472 7 cohort cohort NN cord-010092-uftc8inx 11472 8 study study NN cord-010092-uftc8inx 11472 9 of of IN cord-010092-uftc8inx 11472 10 women woman NNS cord-010092-uftc8inx 11472 11 with with IN cord-010092-uftc8inx 11472 12 persistent persistent JJ cord-010092-uftc8inx 11472 13 postpartum postpartum NN cord-010092-uftc8inx 11472 14 hemorrhage hemorrhage NN cord-010092-uftc8inx 11472 15 , , , cord-010092-uftc8inx 11472 16 defined define VBN cord-010092-uftc8inx 11472 17 as as IN cord-010092-uftc8inx 11472 18 postpartum postpartum NN cord-010092-uftc8inx 11472 19 hemorrhage hemorrhage NN cord-010092-uftc8inx 11472 20 refractory refractory JJ cord-010092-uftc8inx 11472 21 to to IN cord-010092-uftc8inx 11472 22 first first JJ cord-010092-uftc8inx 11472 23 - - HYPH cord-010092-uftc8inx 11472 24 line line NN cord-010092-uftc8inx 11472 25 measures measure NNS cord-010092-uftc8inx 11472 26 to to TO cord-010092-uftc8inx 11472 27 control control VB cord-010092-uftc8inx 11472 28 bleeding bleeding NN cord-010092-uftc8inx 11472 29 . . . cord-010092-uftc8inx 11473 1 Women woman NNS cord-010092-uftc8inx 11473 2 were be VBD cord-010092-uftc8inx 11473 3 enrolled enrol VBN cord-010092-uftc8inx 11473 4 from from IN cord-010092-uftc8inx 11473 5 January January NNP cord-010092-uftc8inx 11473 6 1 1 CD cord-010092-uftc8inx 11473 7 , , , cord-010092-uftc8inx 11473 8 2011 2011 CD cord-010092-uftc8inx 11473 9 to to IN cord-010092-uftc8inx 11473 10 January January NNP cord-010092-uftc8inx 11473 11 1 1 CD cord-010092-uftc8inx 11473 12 , , , cord-010092-uftc8inx 11473 13 2013 2013 CD cord-010092-uftc8inx 11473 14 in in IN cord-010092-uftc8inx 11473 15 61 61 CD cord-010092-uftc8inx 11473 16 Dutch dutch JJ cord-010092-uftc8inx 11473 17 hospitals hospital NNS cord-010092-uftc8inx 11473 18 . . . cord-010092-uftc8inx 11474 1 In in IN cord-010092-uftc8inx 11474 2 a a DT cord-010092-uftc8inx 11474 3 time time NN cord-010092-uftc8inx 11474 4 - - HYPH cord-010092-uftc8inx 11474 5 dependent dependent JJ cord-010092-uftc8inx 11474 6 propensity propensity NN cord-010092-uftc8inx 11474 7 score score RB cord-010092-uftc8inx 11474 8 - - HYPH cord-010092-uftc8inx 11474 9 matched match VBN cord-010092-uftc8inx 11474 10 analysis analysis NN cord-010092-uftc8inx 11474 11 , , , cord-010092-uftc8inx 11474 12 women woman NNS cord-010092-uftc8inx 11474 13 with with IN cord-010092-uftc8inx 11474 14 transfusion transfusion NN cord-010092-uftc8inx 11474 15 of of IN cord-010092-uftc8inx 11474 16 fresh fresh JJ cord-010092-uftc8inx 11474 17 frozen frozen JJ cord-010092-uftc8inx 11474 18 plasma plasma NN cord-010092-uftc8inx 11474 19 within within IN cord-010092-uftc8inx 11474 20 60 60 CD cord-010092-uftc8inx 11474 21 min min NN cord-010092-uftc8inx 11474 22 following follow VBG cord-010092-uftc8inx 11474 23 the the DT cord-010092-uftc8inx 11474 24 diagnosis diagnosis NN cord-010092-uftc8inx 11474 25 of of IN cord-010092-uftc8inx 11474 26 persistent persistent JJ cord-010092-uftc8inx 11474 27 postpartum postpartum NN cord-010092-uftc8inx 11474 28 hemorrhage hemorrhage NN cord-010092-uftc8inx 11474 29 were be VBD cord-010092-uftc8inx 11474 30 matched match VBN cord-010092-uftc8inx 11474 31 to to IN cord-010092-uftc8inx 11474 32 women woman NNS cord-010092-uftc8inx 11474 33 without without IN cord-010092-uftc8inx 11474 34 plasma plasma NN cord-010092-uftc8inx 11474 35 transfusion transfusion NN cord-010092-uftc8inx 11474 36 or or CC cord-010092-uftc8inx 11474 37 plasma plasma NN cord-010092-uftc8inx 11474 38 transfusion transfusion NN cord-010092-uftc8inx 11474 39 at at IN cord-010092-uftc8inx 11474 40 a a DT cord-010092-uftc8inx 11474 41 later later JJ cord-010092-uftc8inx 11474 42 time time NN cord-010092-uftc8inx 11474 43 point point NN cord-010092-uftc8inx 11474 44 during during IN cord-010092-uftc8inx 11474 45 hemorrhage hemorrhage NN cord-010092-uftc8inx 11474 46 . . . cord-010092-uftc8inx 11475 1 Plasma plasma NN cord-010092-uftc8inx 11475 2 transfusion transfusion NN cord-010092-uftc8inx 11475 3 was be VBD cord-010092-uftc8inx 11475 4 not not RB cord-010092-uftc8inx 11475 5 guided guide VBN cord-010092-uftc8inx 11475 6 by by IN cord-010092-uftc8inx 11475 7 coagulation coagulation NN cord-010092-uftc8inx 11475 8 tests test NNS cord-010092-uftc8inx 11475 9 . . . cord-010092-uftc8inx 11476 1 The the DT cord-010092-uftc8inx 11476 2 main main JJ cord-010092-uftc8inx 11476 3 outcome outcome NN cord-010092-uftc8inx 11476 4 measure measure NN cord-010092-uftc8inx 11476 5 was be VBD cord-010092-uftc8inx 11476 6 adverse adverse JJ cord-010092-uftc8inx 11476 7 maternal maternal JJ cord-010092-uftc8inx 11476 8 outcome outcome NN cord-010092-uftc8inx 11476 9 , , , cord-010092-uftc8inx 11476 10 defined define VBN cord-010092-uftc8inx 11476 11 as as IN cord-010092-uftc8inx 11476 12 a a DT cord-010092-uftc8inx 11476 13 composite composite NN cord-010092-uftc8inx 11476 14 of of IN cord-010092-uftc8inx 11476 15 mortality mortality NN cord-010092-uftc8inx 11476 16 , , , cord-010092-uftc8inx 11476 17 hysterectomy hysterectomy NN cord-010092-uftc8inx 11476 18 and and CC cord-010092-uftc8inx 11476 19 arterial arterial JJ cord-010092-uftc8inx 11476 20 embolization embolization NN cord-010092-uftc8inx 11476 21 to to TO cord-010092-uftc8inx 11476 22 control control VB cord-010092-uftc8inx 11476 23 bleeding bleeding NN cord-010092-uftc8inx 11476 24 . . . cord-010092-uftc8inx 11477 1 We -PRON- PRP cord-010092-uftc8inx 11477 2 performed perform VBD cord-010092-uftc8inx 11477 3 sensitivity sensitivity NN cord-010092-uftc8inx 11477 4 analyses analysis NNS cord-010092-uftc8inx 11477 5 with with IN cord-010092-uftc8inx 11477 6 initiation initiation NN cord-010092-uftc8inx 11477 7 of of IN cord-010092-uftc8inx 11477 8 plasma plasma NN cord-010092-uftc8inx 11477 9 transfusion transfusion NN cord-010092-uftc8inx 11477 10 within within IN cord-010092-uftc8inx 11477 11 120 120 CD cord-010092-uftc8inx 11477 12 and and CC cord-010092-uftc8inx 11477 13 within within IN cord-010092-uftc8inx 11477 14 180 180 CD cord-010092-uftc8inx 11477 15 min min NN cord-010092-uftc8inx 11477 16 following follow VBG cord-010092-uftc8inx 11477 17 diagnosis diagnosis NN cord-010092-uftc8inx 11477 18 persistent persistent JJ cord-010092-uftc8inx 11477 19 postpartum postpartum NN cord-010092-uftc8inx 11477 20 hemorrhage hemorrhage NN cord-010092-uftc8inx 11477 21 , , , cord-010092-uftc8inx 11477 22 compared compare VBN cord-010092-uftc8inx 11477 23 with with IN cord-010092-uftc8inx 11477 24 other other JJ cord-010092-uftc8inx 11477 25 plasma plasma NN cord-010092-uftc8inx 11477 26 transfusion transfusion NN cord-010092-uftc8inx 11477 27 strategies strategy NNS cord-010092-uftc8inx 11477 28 . . . cord-010092-uftc8inx 11478 1 Results result NNS cord-010092-uftc8inx 11478 2 Results result NNS cord-010092-uftc8inx 11478 3 : : : cord-010092-uftc8inx 11479 1 The the DT cord-010092-uftc8inx 11479 2 cohort cohort NN cord-010092-uftc8inx 11479 3 consisted consist VBD cord-010092-uftc8inx 11479 4 of of IN cord-010092-uftc8inx 11479 5 1216 1216 CD cord-010092-uftc8inx 11479 6 women woman NNS cord-010092-uftc8inx 11479 7 with with IN cord-010092-uftc8inx 11479 8 persistent persistent JJ cord-010092-uftc8inx 11479 9 postpartum postpartum NN cord-010092-uftc8inx 11479 10 hemorrhage hemorrhage NN cord-010092-uftc8inx 11479 11 , , , cord-010092-uftc8inx 11479 12 with with IN cord-010092-uftc8inx 11479 13 uterine uterine JJ cord-010092-uftc8inx 11479 14 atony atony NN cord-010092-uftc8inx 11479 15 as as IN cord-010092-uftc8inx 11479 16 cause cause NN cord-010092-uftc8inx 11479 17 of of IN cord-010092-uftc8inx 11479 18 hemorrhage hemorrhage NN cord-010092-uftc8inx 11479 19 in in IN cord-010092-uftc8inx 11479 20 780 780 CD cord-010092-uftc8inx 11479 21 women woman NNS cord-010092-uftc8inx 11479 22 ( ( -LRB- cord-010092-uftc8inx 11479 23 64.1 64.1 CD cord-010092-uftc8inx 11479 24 % % NN cord-010092-uftc8inx 11479 25 ) ) -RRB- cord-010092-uftc8inx 11479 26 . . . cord-010092-uftc8inx 11480 1 In in IN cord-010092-uftc8inx 11480 2 this this DT cord-010092-uftc8inx 11480 3 cohort cohort NN cord-010092-uftc8inx 11480 4 , , , cord-010092-uftc8inx 11480 5 seven seven CD cord-010092-uftc8inx 11480 6 maternal maternal JJ cord-010092-uftc8inx 11480 7 deaths death NNS cord-010092-uftc8inx 11480 8 ( ( -LRB- cord-010092-uftc8inx 11480 9 0.6 0.6 CD cord-010092-uftc8inx 11480 10 % % NN cord-010092-uftc8inx 11480 11 ) ) -RRB- cord-010092-uftc8inx 11480 12 , , , cord-010092-uftc8inx 11480 13 62 62 CD cord-010092-uftc8inx 11480 14 hysterectomies hysterectomy NNS cord-010092-uftc8inx 11480 15 ( ( -LRB- cord-010092-uftc8inx 11480 16 5.1 5.1 CD cord-010092-uftc8inx 11480 17 % % NN cord-010092-uftc8inx 11480 18 ) ) -RRB- cord-010092-uftc8inx 11480 19 and and CC cord-010092-uftc8inx 11480 20 159 159 CD cord-010092-uftc8inx 11480 21 arterial arterial JJ cord-010092-uftc8inx 11480 22 embolizations embolization NNS cord-010092-uftc8inx 11480 23 ( ( -LRB- cord-010092-uftc8inx 11480 24 13.1 13.1 CD cord-010092-uftc8inx 11480 25 % % NN cord-010092-uftc8inx 11480 26 ) ) -RRB- cord-010092-uftc8inx 11480 27 were be VBD cord-010092-uftc8inx 11480 28 observed observe VBN cord-010092-uftc8inx 11480 29 . . . cord-010092-uftc8inx 11481 1 Plasma plasma NN cord-010092-uftc8inx 11481 2 transfusion transfusion NN cord-010092-uftc8inx 11481 3 within within IN cord-010092-uftc8inx 11481 4 60 60 CD cord-010092-uftc8inx 11481 5 min min NN cord-010092-uftc8inx 11481 6 in in IN cord-010092-uftc8inx 11481 7 114 114 CD cord-010092-uftc8inx 11481 8 women woman NNS cord-010092-uftc8inx 11481 9 was be VBD cord-010092-uftc8inx 11481 10 matched match VBN cord-010092-uftc8inx 11481 11 on on IN cord-010092-uftc8inx 11481 12 time time NN cord-010092-uftc8inx 11481 13 - - HYPH cord-010092-uftc8inx 11481 14 dependent dependent JJ cord-010092-uftc8inx 11481 15 propensity propensity NN cord-010092-uftc8inx 11481 16 scores score NNS cord-010092-uftc8inx 11481 17 with with IN cord-010092-uftc8inx 11481 18 114 114 CD cord-010092-uftc8inx 11481 19 women woman NNS cord-010092-uftc8inx 11481 20 with with IN cord-010092-uftc8inx 11481 21 no no DT cord-010092-uftc8inx 11481 22 or or CC cord-010092-uftc8inx 11481 23 later later JJ cord-010092-uftc8inx 11481 24 plasma plasma NN cord-010092-uftc8inx 11481 25 transfusion transfusion NN cord-010092-uftc8inx 11481 26 . . . cord-010092-uftc8inx 11482 1 Rate rate NN cord-010092-uftc8inx 11482 2 of of IN cord-010092-uftc8inx 11482 3 adverse adverse JJ cord-010092-uftc8inx 11482 4 maternal maternal JJ cord-010092-uftc8inx 11482 5 outcome outcome NN cord-010092-uftc8inx 11482 6 was be VBD cord-010092-uftc8inx 11482 7 similar similar JJ cord-010092-uftc8inx 11482 8 between between IN cord-010092-uftc8inx 11482 9 women woman NNS cord-010092-uftc8inx 11482 10 with with IN cord-010092-uftc8inx 11482 11 and and CC cord-010092-uftc8inx 11482 12 without without IN cord-010092-uftc8inx 11482 13 early early JJ cord-010092-uftc8inx 11482 14 plasma plasma NN cord-010092-uftc8inx 11482 15 transfusion transfusion NN cord-010092-uftc8inx 11482 16 , , , cord-010092-uftc8inx 11482 17 21.2 21.2 CD cord-010092-uftc8inx 11482 18 % % NN cord-010092-uftc8inx 11482 19 versus versus IN cord-010092-uftc8inx 11482 20 19.9 19.9 CD cord-010092-uftc8inx 11482 21 % % NN cord-010092-uftc8inx 11482 22 , , , cord-010092-uftc8inx 11482 23 adjusted adjusted JJ cord-010092-uftc8inx 11482 24 odds odd NNS cord-010092-uftc8inx 11482 25 ratio ratio NN cord-010092-uftc8inx 11482 26 1.09 1.09 CD cord-010092-uftc8inx 11482 27 ( ( -LRB- cord-010092-uftc8inx 11482 28 95 95 CD cord-010092-uftc8inx 11482 29 % % NN cord-010092-uftc8inx 11482 30 confidence confidence NN cord-010092-uftc8inx 11482 31 interval interval NN cord-010092-uftc8inx 11482 32 0.57 0.57 CD cord-010092-uftc8inx 11482 33 - - SYM cord-010092-uftc8inx 11482 34 2.08 2.08 CD cord-010092-uftc8inx 11482 35 ) ) -RRB- cord-010092-uftc8inx 11482 36 . . . cord-010092-uftc8inx 11483 1 Results result NNS cord-010092-uftc8inx 11483 2 of of IN cord-010092-uftc8inx 11483 3 sensitivity sensitivity NN cord-010092-uftc8inx 11483 4 analyses analysis NNS cord-010092-uftc8inx 11483 5 were be VBD cord-010092-uftc8inx 11483 6 comparable comparable JJ cord-010092-uftc8inx 11483 7 to to IN cord-010092-uftc8inx 11483 8 the the DT cord-010092-uftc8inx 11483 9 primary primary JJ cord-010092-uftc8inx 11483 10 results result NNS cord-010092-uftc8inx 11483 11 . . . cord-010092-uftc8inx 11484 1 Summary Summary NNP cord-010092-uftc8inx 11484 2 / / SYM cord-010092-uftc8inx 11484 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 11484 4 : : : cord-010092-uftc8inx 11485 1 Among among IN cord-010092-uftc8inx 11485 2 women woman NNS cord-010092-uftc8inx 11485 3 with with IN cord-010092-uftc8inx 11485 4 persistent persistent JJ cord-010092-uftc8inx 11485 5 postpartum postpartum NN cord-010092-uftc8inx 11485 6 hemorrhage hemorrhage NN cord-010092-uftc8inx 11485 7 , , , cord-010092-uftc8inx 11485 8 initiation initiation NN cord-010092-uftc8inx 11485 9 of of IN cord-010092-uftc8inx 11485 10 plasma plasma NN cord-010092-uftc8inx 11485 11 transfusion transfusion NN cord-010092-uftc8inx 11485 12 within within IN cord-010092-uftc8inx 11485 13 60 60 CD cord-010092-uftc8inx 11485 14 min min NN cord-010092-uftc8inx 11485 15 following follow VBG cord-010092-uftc8inx 11485 16 this this DT cord-010092-uftc8inx 11485 17 diagnosis diagnosis NN cord-010092-uftc8inx 11485 18 was be VBD cord-010092-uftc8inx 11485 19 not not RB cord-010092-uftc8inx 11485 20 associated associate VBN cord-010092-uftc8inx 11485 21 with with IN cord-010092-uftc8inx 11485 22 improved improved JJ cord-010092-uftc8inx 11485 23 maternal maternal JJ cord-010092-uftc8inx 11485 24 outcomes outcome NNS cord-010092-uftc8inx 11485 25 , , , cord-010092-uftc8inx 11485 26 compared compare VBN cord-010092-uftc8inx 11485 27 with with IN cord-010092-uftc8inx 11485 28 no no DT cord-010092-uftc8inx 11485 29 or or CC cord-010092-uftc8inx 11485 30 later later JJ cord-010092-uftc8inx 11485 31 plasma plasma NN cord-010092-uftc8inx 11485 32 transfusion transfusion NN cord-010092-uftc8inx 11485 33 . . . cord-010092-uftc8inx 11486 1 Whether whether IN cord-010092-uftc8inx 11486 2 other other JJ cord-010092-uftc8inx 11486 3 transfusion transfusion NN cord-010092-uftc8inx 11486 4 strategies strategy NNS cord-010092-uftc8inx 11486 5 or or CC cord-010092-uftc8inx 11486 6 identification identification NN cord-010092-uftc8inx 11486 7 of of IN cord-010092-uftc8inx 11486 8 women woman NNS cord-010092-uftc8inx 11486 9 with with IN cord-010092-uftc8inx 11486 10 high high JJ cord-010092-uftc8inx 11486 11 risk risk NN cord-010092-uftc8inx 11486 12 of of IN cord-010092-uftc8inx 11486 13 coagulopathy coagulopathy NN cord-010092-uftc8inx 11486 14 will will MD cord-010092-uftc8inx 11486 15 improve improve VB cord-010092-uftc8inx 11486 16 maternal maternal JJ cord-010092-uftc8inx 11486 17 outcomes outcome NNS cord-010092-uftc8inx 11486 18 remains remain VBZ cord-010092-uftc8inx 11486 19 to to TO cord-010092-uftc8inx 11486 20 be be VB cord-010092-uftc8inx 11486 21 studied study VBN cord-010092-uftc8inx 11486 22 . . . cord-010092-uftc8inx 11487 1 Background background NN cord-010092-uftc8inx 11487 2 : : : cord-010092-uftc8inx 11488 1 Preoperative preoperative JJ cord-010092-uftc8inx 11488 2 evaluation evaluation NN cord-010092-uftc8inx 11488 3 of of IN cord-010092-uftc8inx 11488 4 increased increase VBN cord-010092-uftc8inx 11488 5 risk risk NN cord-010092-uftc8inx 11488 6 for for IN cord-010092-uftc8inx 11488 7 perioperative perioperative JJ cord-010092-uftc8inx 11488 8 bleeding bleeding NN cord-010092-uftc8inx 11488 9 is be VBZ cord-010092-uftc8inx 11488 10 essential essential JJ cord-010092-uftc8inx 11488 11 for for IN cord-010092-uftc8inx 11488 12 cardiac cardiac JJ cord-010092-uftc8inx 11488 13 surgery surgery NN cord-010092-uftc8inx 11488 14 patients patient NNS cord-010092-uftc8inx 11488 15 . . . cord-010092-uftc8inx 11489 1 Platelet platelet NN cord-010092-uftc8inx 11489 2 aggregation aggregation NN cord-010092-uftc8inx 11489 3 , , , cord-010092-uftc8inx 11489 4 as as IN cord-010092-uftc8inx 11489 5 a a DT cord-010092-uftc8inx 11489 6 laboratory laboratory NN cord-010092-uftc8inx 11489 7 test test NN cord-010092-uftc8inx 11489 8 for for IN cord-010092-uftc8inx 11489 9 assessment assessment NN cord-010092-uftc8inx 11489 10 of of IN cord-010092-uftc8inx 11489 11 platelet platelet NN cord-010092-uftc8inx 11489 12 function function NN cord-010092-uftc8inx 11489 13 , , , cord-010092-uftc8inx 11489 14 is be VBZ cord-010092-uftc8inx 11489 15 very very RB cord-010092-uftc8inx 11489 16 efficient efficient JJ cord-010092-uftc8inx 11489 17 for for IN cord-010092-uftc8inx 11489 18 optimal optimal JJ cord-010092-uftc8inx 11490 1 antiplatelet antiplatelet JJ cord-010092-uftc8inx 11490 2 treatment treatment NN cord-010092-uftc8inx 11490 3 and and CC cord-010092-uftc8inx 11491 1 also also RB cord-010092-uftc8inx 11491 2 for for IN cord-010092-uftc8inx 11491 3 assessment assessment NN cord-010092-uftc8inx 11491 4 of of IN cord-010092-uftc8inx 11491 5 the the DT cord-010092-uftc8inx 11491 6 increased increase VBN cord-010092-uftc8inx 11491 7 risk risk NN cord-010092-uftc8inx 11491 8 of of IN cord-010092-uftc8inx 11491 9 postoperative postoperative JJ cord-010092-uftc8inx 11491 10 bleeding bleeding NN cord-010092-uftc8inx 11491 11 and and CC cord-010092-uftc8inx 11491 12 perioperative perioperative JJ cord-010092-uftc8inx 11491 13 application application NN cord-010092-uftc8inx 11491 14 of of IN cord-010092-uftc8inx 11491 15 allogenic allogenic JJ cord-010092-uftc8inx 11491 16 red red JJ cord-010092-uftc8inx 11491 17 blood blood NN cord-010092-uftc8inx 11491 18 cell cell NN cord-010092-uftc8inx 11491 19 transfusions transfusion NNS cord-010092-uftc8inx 11491 20 . . . cord-010092-uftc8inx 11492 1 Aims aim VBZ cord-010092-uftc8inx 11492 2 : : : cord-010092-uftc8inx 11493 1 The the DT cord-010092-uftc8inx 11493 2 aim aim NN cord-010092-uftc8inx 11493 3 of of IN cord-010092-uftc8inx 11493 4 this this DT cord-010092-uftc8inx 11493 5 study study NN cord-010092-uftc8inx 11493 6 was be VBD cord-010092-uftc8inx 11493 7 to to TO cord-010092-uftc8inx 11493 8 establish establish VB cord-010092-uftc8inx 11493 9 whether whether IN cord-010092-uftc8inx 11493 10 preoperative preoperative JJ cord-010092-uftc8inx 11493 11 platelet platelet NN cord-010092-uftc8inx 11493 12 function function NN cord-010092-uftc8inx 11493 13 testing test VBG cord-010092-uftc8inx 11493 14 for for IN cord-010092-uftc8inx 11493 15 the the DT cord-010092-uftc8inx 11493 16 presence presence NN cord-010092-uftc8inx 11493 17 of of IN cord-010092-uftc8inx 11493 18 residual residual JJ cord-010092-uftc8inx 11493 19 effect effect NN cord-010092-uftc8inx 11493 20 of of IN cord-010092-uftc8inx 11493 21 acetylsalicylic acetylsalicylic JJ cord-010092-uftc8inx 11493 22 acid acid NN cord-010092-uftc8inx 11493 23 ( ( -LRB- cord-010092-uftc8inx 11493 24 ASA ASA NNP cord-010092-uftc8inx 11493 25 ) ) -RRB- cord-010092-uftc8inx 11493 26 on on IN cord-010092-uftc8inx 11493 27 platelet platelet NN cord-010092-uftc8inx 11493 28 aggregation aggregation NN cord-010092-uftc8inx 11493 29 can can MD cord-010092-uftc8inx 11493 30 be be VB cord-010092-uftc8inx 11493 31 correlated correlate VBN cord-010092-uftc8inx 11493 32 with with IN cord-010092-uftc8inx 11493 33 an an DT cord-010092-uftc8inx 11493 34 increased increase VBN cord-010092-uftc8inx 11493 35 risk risk NN cord-010092-uftc8inx 11493 36 for for IN cord-010092-uftc8inx 11493 37 intraoperative intraoperative JJ cord-010092-uftc8inx 11493 38 bleeding bleeding NN cord-010092-uftc8inx 11493 39 during during IN cord-010092-uftc8inx 11493 40 cardiac cardiac JJ cord-010092-uftc8inx 11493 41 interventions intervention NNS cord-010092-uftc8inx 11493 42 . . . cord-010092-uftc8inx 11494 1 Methods method NNS cord-010092-uftc8inx 11494 2 : : : cord-010092-uftc8inx 11495 1 A a DT cord-010092-uftc8inx 11495 2 retrospective retrospective JJ cord-010092-uftc8inx 11495 3 study study NN cord-010092-uftc8inx 11495 4 included include VBD cord-010092-uftc8inx 11495 5 60 60 CD cord-010092-uftc8inx 11495 6 patients patient NNS cord-010092-uftc8inx 11495 7 who who WP cord-010092-uftc8inx 11495 8 underwent undergo VBD cord-010092-uftc8inx 11495 9 surgical surgical JJ cord-010092-uftc8inx 11495 10 procedures procedure NNS cord-010092-uftc8inx 11495 11 ( ( -LRB- cord-010092-uftc8inx 11495 12 CABG CABG NNP cord-010092-uftc8inx 11495 13 II II NNP cord-010092-uftc8inx 11495 14 and and CC cord-010092-uftc8inx 11495 15 CABG CABG NNP cord-010092-uftc8inx 11495 16 III III NNP cord-010092-uftc8inx 11495 17 ) ) -RRB- cord-010092-uftc8inx 11495 18 at at IN cord-010092-uftc8inx 11495 19 the the DT cord-010092-uftc8inx 11495 20 Department Department NNP cord-010092-uftc8inx 11495 21 of of IN cord-010092-uftc8inx 11495 22 Cardiovascular Cardiovascular NNP cord-010092-uftc8inx 11495 23 Surgery Surgery NNP cord-010092-uftc8inx 11495 24 , , , cord-010092-uftc8inx 11495 25 Clinical Clinical NNP cord-010092-uftc8inx 11495 26 Center Center NNP cord-010092-uftc8inx 11495 27 in in IN cord-010092-uftc8inx 11495 28 Ni Ni NNP cord-010092-uftc8inx 11495 29 s s NNP cord-010092-uftc8inx 11495 30 in in IN cord-010092-uftc8inx 11495 31 period period NN cord-010092-uftc8inx 11495 32 November November NNP cord-010092-uftc8inx 11495 33 2017-July 2017-july CD cord-010092-uftc8inx 11495 34 2018 2018 CD cord-010092-uftc8inx 11495 35 . . . cord-010092-uftc8inx 11496 1 Patients patient NNS cord-010092-uftc8inx 11496 2 were be VBD cord-010092-uftc8inx 11496 3 previously previously RB cord-010092-uftc8inx 11496 4 taken take VBN cord-010092-uftc8inx 11496 5 ASA ASA NNP cord-010092-uftc8inx 11496 6 at at IN cord-010092-uftc8inx 11496 7 a a DT cord-010092-uftc8inx 11496 8 dose dose NN cord-010092-uftc8inx 11496 9 of of IN cord-010092-uftc8inx 11496 10 100 100 CD cord-010092-uftc8inx 11496 11 mg mg NN cord-010092-uftc8inx 11496 12 per per IN cord-010092-uftc8inx 11496 13 day day NN cord-010092-uftc8inx 11496 14 , , , cord-010092-uftc8inx 11496 15 but but CC cord-010092-uftc8inx 11496 16 therapy therapy NN cord-010092-uftc8inx 11496 17 was be VBD cord-010092-uftc8inx 11496 18 discontinued discontinue VBN cord-010092-uftc8inx 11496 19 5 5 CD cord-010092-uftc8inx 11496 20 days day NNS cord-010092-uftc8inx 11496 21 before before IN cord-010092-uftc8inx 11496 22 surgery surgery NN cord-010092-uftc8inx 11496 23 . . . cord-010092-uftc8inx 11497 1 Platelet platelet NN cord-010092-uftc8inx 11497 2 aggregation aggregation NN cord-010092-uftc8inx 11497 3 was be VBD cord-010092-uftc8inx 11497 4 measured measure VBN cord-010092-uftc8inx 11497 5 on on IN cord-010092-uftc8inx 11497 6 the the DT cord-010092-uftc8inx 11497 7 day day NN cord-010092-uftc8inx 11497 8 of of IN cord-010092-uftc8inx 11497 9 surgery surgery NN cord-010092-uftc8inx 11497 10 using use VBG cord-010092-uftc8inx 11497 11 impedance impedance NN cord-010092-uftc8inx 11497 12 aggregometer aggregometer NN cord-010092-uftc8inx 11497 13 Multiplate Multiplate NNP cord-010092-uftc8inx 11497 14 ( ( -LRB- cord-010092-uftc8inx 11497 15 Multiplate Multiplate NNP cord-010092-uftc8inx 11497 16 Platelet Platelet NNP cord-010092-uftc8inx 11497 17 Function Function NNP cord-010092-uftc8inx 11497 18 Analyzer Analyzer NNP cord-010092-uftc8inx 11497 19 , , , cord-010092-uftc8inx 11497 20 Roche Roche NNP cord-010092-uftc8inx 11497 21 ) ) -RRB- cord-010092-uftc8inx 11497 22 , , , cord-010092-uftc8inx 11497 23 using use VBG cord-010092-uftc8inx 11497 24 TRAP trap NN cord-010092-uftc8inx 11497 25 and and CC cord-010092-uftc8inx 11497 26 ASPI ASPI NNP cord-010092-uftc8inx 11497 27 tests test NNS cord-010092-uftc8inx 11497 28 . . . cord-010092-uftc8inx 11498 1 Patients patient NNS cord-010092-uftc8inx 11498 2 were be VBD cord-010092-uftc8inx 11498 3 divided divide VBN cord-010092-uftc8inx 11498 4 into into IN cord-010092-uftc8inx 11498 5 two two CD cord-010092-uftc8inx 11498 6 groups group NNS cord-010092-uftc8inx 11498 7 : : : cord-010092-uftc8inx 11498 8 Control Control NNP cord-010092-uftc8inx 11498 9 group group NN cord-010092-uftc8inx 11498 10 ( ( -LRB- cord-010092-uftc8inx 11498 11 CG CG NNP cord-010092-uftc8inx 11498 12 ) ) -RRB- cord-010092-uftc8inx 11498 13 , , , cord-010092-uftc8inx 11498 14 which which WDT cord-010092-uftc8inx 11498 15 included include VBD cord-010092-uftc8inx 11498 16 patients patient NNS cord-010092-uftc8inx 11498 17 with with IN cord-010092-uftc8inx 11498 18 preserved preserved JJ cord-010092-uftc8inx 11498 19 function function NN cord-010092-uftc8inx 11498 20 of of IN cord-010092-uftc8inx 11498 21 platelets platelet NNS cord-010092-uftc8inx 11498 22 ( ( -LRB- cord-010092-uftc8inx 11498 23 ASPI ASPI NNP cord-010092-uftc8inx 11498 24 790 790 CD cord-010092-uftc8inx 11498 25 - - HYPH cord-010092-uftc8inx 11498 26 1410 1410 CD cord-010092-uftc8inx 11498 27 AU*min AU*min NNP cord-010092-uftc8inx 11498 28 ) ) -RRB- cord-010092-uftc8inx 11498 29 , , , cord-010092-uftc8inx 11498 30 and and CC cord-010092-uftc8inx 11498 31 Examined examine VBN cord-010092-uftc8inx 11498 32 group group NN cord-010092-uftc8inx 11498 33 ( ( -LRB- cord-010092-uftc8inx 11498 34 EG EG NNP cord-010092-uftc8inx 11498 35 ) ) -RRB- cord-010092-uftc8inx 11498 36 , , , cord-010092-uftc8inx 11498 37 which which WDT cord-010092-uftc8inx 11498 38 included include VBD cord-010092-uftc8inx 11498 39 patients patient NNS cord-010092-uftc8inx 11498 40 with with IN cord-010092-uftc8inx 11498 41 inhibited inhibited JJ cord-010092-uftc8inx 11498 42 platelet platelet NN cord-010092-uftc8inx 11498 43 aggregation aggregation NN cord-010092-uftc8inx 11498 44 in in IN cord-010092-uftc8inx 11498 45 ASPI ASPI NNP cord-010092-uftc8inx 11498 46 test test NN cord-010092-uftc8inx 11498 47 ( ( -LRB- cord-010092-uftc8inx 11498 48 < < XX cord-010092-uftc8inx 11498 49 790 790 CD cord-010092-uftc8inx 11498 50 AU AU NNP cord-010092-uftc8inx 11498 51 * * NFP cord-010092-uftc8inx 11498 52 min min NN cord-010092-uftc8inx 11498 53 Background background NN cord-010092-uftc8inx 11498 54 : : : cord-010092-uftc8inx 11499 1 Hemophilia Hemophilia NNP cord-010092-uftc8inx 11499 2 B B NNP cord-010092-uftc8inx 11499 3 is be VBZ cord-010092-uftc8inx 11499 4 an an DT cord-010092-uftc8inx 11499 5 X x NN cord-010092-uftc8inx 11499 6 - - NN cord-010092-uftc8inx 11499 7 chromosome chromosome NN cord-010092-uftc8inx 11499 8 - - HYPH cord-010092-uftc8inx 11499 9 linked link VBN cord-010092-uftc8inx 11499 10 inherited inherit VBN cord-010092-uftc8inx 11499 11 bleeding bleed VBG cord-010092-uftc8inx 11499 12 disorder disorder NN cord-010092-uftc8inx 11499 13 resulting result VBG cord-010092-uftc8inx 11499 14 from from IN cord-010092-uftc8inx 11499 15 reduced reduce VBN cord-010092-uftc8inx 11499 16 levels level NNS cord-010092-uftc8inx 11499 17 or or CC cord-010092-uftc8inx 11499 18 an an DT cord-010092-uftc8inx 11499 19 absence absence NN cord-010092-uftc8inx 11499 20 of of IN cord-010092-uftc8inx 11499 21 factor factor NN cord-010092-uftc8inx 11499 22 IX IX NNP cord-010092-uftc8inx 11499 23 clinically clinically RB cord-010092-uftc8inx 11499 24 represented represent VBN cord-010092-uftc8inx 11499 25 by by IN cord-010092-uftc8inx 11499 26 recurrent recurrent JJ cord-010092-uftc8inx 11499 27 prolonged prolong VBN cord-010092-uftc8inx 11499 28 bleeding bleeding NN cord-010092-uftc8inx 11499 29 . . . cord-010092-uftc8inx 11500 1 Mutations mutation NNS cord-010092-uftc8inx 11500 2 can can MD cord-010092-uftc8inx 11500 3 be be VB cord-010092-uftc8inx 11500 4 inherited inherit VBN cord-010092-uftc8inx 11500 5 or or CC cord-010092-uftc8inx 11500 6 acquired acquire VBN cord-010092-uftc8inx 11500 7 de de IN cord-010092-uftc8inx 11500 8 novo novo NNP cord-010092-uftc8inx 11500 9 . . . cord-010092-uftc8inx 11501 1 De De NNP cord-010092-uftc8inx 11501 2 novo novo NNP cord-010092-uftc8inx 11501 3 mutations mutation NNS cord-010092-uftc8inx 11501 4 arise arise VBP cord-010092-uftc8inx 11501 5 in in IN cord-010092-uftc8inx 11501 6 about about RB cord-010092-uftc8inx 11501 7 one one CD cord-010092-uftc8inx 11501 8 - - HYPH cord-010092-uftc8inx 11501 9 third third NN cord-010092-uftc8inx 11501 10 of of IN cord-010092-uftc8inx 11501 11 patients patient NNS cord-010092-uftc8inx 11501 12 with with IN cord-010092-uftc8inx 11501 13 haemophilia haemophilia NN cord-010092-uftc8inx 11501 14 . . . cord-010092-uftc8inx 11502 1 The the DT cord-010092-uftc8inx 11502 2 disease disease NN cord-010092-uftc8inx 11502 3 affects affect VBZ cord-010092-uftc8inx 11502 4 primarily primarily RB cord-010092-uftc8inx 11502 5 males male NNS cord-010092-uftc8inx 11502 6 , , , cord-010092-uftc8inx 11502 7 but but CC cord-010092-uftc8inx 11502 8 approximately approximately RB cord-010092-uftc8inx 11502 9 30 30 CD cord-010092-uftc8inx 11502 10 % % NN cord-010092-uftc8inx 11502 11 of of IN cord-010092-uftc8inx 11502 12 carrier carrier NN cord-010092-uftc8inx 11502 13 females female NNS cord-010092-uftc8inx 11502 14 have have VBP cord-010092-uftc8inx 11502 15 factor factor NN cord-010092-uftc8inx 11502 16 IX IX NNP cord-010092-uftc8inx 11502 17 clotting clotting NN cord-010092-uftc8inx 11502 18 activity activity NN cord-010092-uftc8inx 11502 19 lower low JJR cord-010092-uftc8inx 11502 20 than than IN cord-010092-uftc8inx 11502 21 40 40 CD cord-010092-uftc8inx 11502 22 % % NN cord-010092-uftc8inx 11502 23 and and CC cord-010092-uftc8inx 11502 24 are be VBP cord-010092-uftc8inx 11502 25 at at IN cord-010092-uftc8inx 11502 26 risk risk NN cord-010092-uftc8inx 11502 27 for for IN cord-010092-uftc8inx 11502 28 bleeding bleed VBG cord-010092-uftc8inx 11502 29 . . . cord-010092-uftc8inx 11503 1 Aims aim VBZ cord-010092-uftc8inx 11503 2 : : : cord-010092-uftc8inx 11504 1 case case NNP cord-010092-uftc8inx 11504 2 report report NN cord-010092-uftc8inx 11504 3 of of IN cord-010092-uftc8inx 11504 4 a a DT cord-010092-uftc8inx 11504 5 Hemophilia Hemophilia NNP cord-010092-uftc8inx 11504 6 B B NNP cord-010092-uftc8inx 11504 7 carrier carrier NN cord-010092-uftc8inx 11504 8 . . . cord-010092-uftc8inx 11505 1 Methods method NNS cord-010092-uftc8inx 11505 2 : : : cord-010092-uftc8inx 11505 3 the the DT cord-010092-uftc8inx 11505 4 clinical clinical JJ cord-010092-uftc8inx 11505 5 history history NN cord-010092-uftc8inx 11505 6 of of IN cord-010092-uftc8inx 11505 7 the the DT cord-010092-uftc8inx 11505 8 patient patient NN cord-010092-uftc8inx 11505 9 was be VBD cord-010092-uftc8inx 11505 10 thoroughly thoroughly RB cord-010092-uftc8inx 11505 11 studied study VBN cord-010092-uftc8inx 11505 12 by by IN cord-010092-uftc8inx 11505 13 analyzing analyze VBG cord-010092-uftc8inx 11505 14 medical medical JJ cord-010092-uftc8inx 11505 15 records record NNS cord-010092-uftc8inx 11505 16 and and CC cord-010092-uftc8inx 11505 17 analytical analytical JJ cord-010092-uftc8inx 11505 18 results result NNS cord-010092-uftc8inx 11505 19 using use VBG cord-010092-uftc8inx 11505 20 the the DT cord-010092-uftc8inx 11505 21 software software NN cord-010092-uftc8inx 11505 22 available available JJ cord-010092-uftc8inx 11505 23 in in IN cord-010092-uftc8inx 11505 24 the the DT cord-010092-uftc8inx 11505 25 health health NN cord-010092-uftc8inx 11505 26 institution institution NN cord-010092-uftc8inx 11505 27 and and CC cord-010092-uftc8inx 11505 28 paper paper NN cord-010092-uftc8inx 11505 29 records record NNS cord-010092-uftc8inx 11505 30 . . . cord-010092-uftc8inx 11506 1 Results result NNS cord-010092-uftc8inx 11506 2 : : : cord-010092-uftc8inx 11506 3 45 45 CD cord-010092-uftc8inx 11506 4 year year NN cord-010092-uftc8inx 11506 5 old old JJ cord-010092-uftc8inx 11506 6 woman woman NN cord-010092-uftc8inx 11506 7 , , , cord-010092-uftc8inx 11506 8 with with IN cord-010092-uftc8inx 11506 9 no no DT cord-010092-uftc8inx 11506 10 history history NN cord-010092-uftc8inx 11506 11 of of IN cord-010092-uftc8inx 11506 12 abnormal abnormal JJ cord-010092-uftc8inx 11506 13 haemorrhage haemorrhage NN cord-010092-uftc8inx 11506 14 , , , cord-010092-uftc8inx 11506 15 healthy healthy JJ cord-010092-uftc8inx 11506 16 , , , cord-010092-uftc8inx 11506 17 up up IN cord-010092-uftc8inx 11506 18 to to IN cord-010092-uftc8inx 11506 19 2004 2004 CD cord-010092-uftc8inx 11506 20 when when WRB cord-010092-uftc8inx 11506 21 , , , cord-010092-uftc8inx 11506 22 after after IN cord-010092-uftc8inx 11506 23 a a DT cord-010092-uftc8inx 11506 24 dystocic dystocic JJ cord-010092-uftc8inx 11506 25 delivery delivery NN cord-010092-uftc8inx 11506 26 , , , cord-010092-uftc8inx 11506 27 presents present VBZ cord-010092-uftc8inx 11506 28 with with IN cord-010092-uftc8inx 11506 29 subcutaneous subcutaneous JJ cord-010092-uftc8inx 11506 30 and and CC cord-010092-uftc8inx 11506 31 ocular ocular JJ cord-010092-uftc8inx 11506 32 haemorrhage haemorrhage NN cord-010092-uftc8inx 11506 33 and and CC cord-010092-uftc8inx 11506 34 dispersed disperse VBD cord-010092-uftc8inx 11506 35 bruises bruise NNS cord-010092-uftc8inx 11506 36 . . . cord-010092-uftc8inx 11507 1 A a DT cord-010092-uftc8inx 11507 2 basic basic JJ cord-010092-uftc8inx 11507 3 coagulation coagulation NN cord-010092-uftc8inx 11507 4 study study NN cord-010092-uftc8inx 11507 5 is be VBZ cord-010092-uftc8inx 11507 6 performed perform VBN cord-010092-uftc8inx 11507 7 and and CC cord-010092-uftc8inx 11507 8 a a DT cord-010092-uftc8inx 11507 9 level level NN cord-010092-uftc8inx 11507 10 of of IN cord-010092-uftc8inx 11507 11 20 20 CD cord-010092-uftc8inx 11507 12 % % NN cord-010092-uftc8inx 11507 13 FIX fix NN cord-010092-uftc8inx 11507 14 is be VBZ cord-010092-uftc8inx 11507 15 found find VBN cord-010092-uftc8inx 11507 16 . . . cord-010092-uftc8inx 11508 1 Genetic genetic JJ cord-010092-uftc8inx 11508 2 analysis analysis NN cord-010092-uftc8inx 11508 3 reveals reveal VBZ cord-010092-uftc8inx 11508 4 a a DT cord-010092-uftc8inx 11508 5 mutation mutation NN cord-010092-uftc8inx 11508 6 in in IN cord-010092-uftc8inx 11508 7 FIX fix NN cord-010092-uftc8inx 11508 8 gene gene NN cord-010092-uftc8inx 11508 9 and and CC cord-010092-uftc8inx 11508 10 she -PRON- PRP cord-010092-uftc8inx 11508 11 is be VBZ cord-010092-uftc8inx 11508 12 diagnosed diagnose VBN cord-010092-uftc8inx 11508 13 as as IN cord-010092-uftc8inx 11508 14 a a DT cord-010092-uftc8inx 11508 15 carrier carrier NN cord-010092-uftc8inx 11508 16 of of IN cord-010092-uftc8inx 11509 1 Hemophilia Hemophilia NNP cord-010092-uftc8inx 11509 2 B. B. NNP cord-010092-uftc8inx 11509 3 Except Except NNP cord-010092-uftc8inx 11509 4 for for IN cord-010092-uftc8inx 11509 5 a a DT cord-010092-uftc8inx 11509 6 son son NN cord-010092-uftc8inx 11509 7 , , , cord-010092-uftc8inx 11509 8 no no DT cord-010092-uftc8inx 11509 9 other other JJ cord-010092-uftc8inx 11509 10 direct direct JJ cord-010092-uftc8inx 11509 11 family family NN cord-010092-uftc8inx 11509 12 members member NNS cord-010092-uftc8inx 11509 13 carry carry VBP cord-010092-uftc8inx 11509 14 the the DT cord-010092-uftc8inx 11509 15 mutation mutation NN cord-010092-uftc8inx 11509 16 . . . cord-010092-uftc8inx 11510 1 In in IN cord-010092-uftc8inx 11510 2 2008 2008 CD cord-010092-uftc8inx 11510 3 , , , cord-010092-uftc8inx 11510 4 after after IN cord-010092-uftc8inx 11510 5 total total JJ cord-010092-uftc8inx 11510 6 hysterectomy hysterectomy NN cord-010092-uftc8inx 11510 7 with with IN cord-010092-uftc8inx 11510 8 bilateral bilateral JJ cord-010092-uftc8inx 11510 9 adnexectomy adnexectomy NN cord-010092-uftc8inx 11510 10 due due IN cord-010092-uftc8inx 11510 11 to to IN cord-010092-uftc8inx 11510 12 an an DT cord-010092-uftc8inx 11510 13 invasive invasive JJ cord-010092-uftc8inx 11510 14 carcinoma carcinoma NN cord-010092-uftc8inx 11510 15 in in IN cord-010092-uftc8inx 11510 16 the the DT cord-010092-uftc8inx 11510 17 uterine uterine JJ cord-010092-uftc8inx 11510 18 cervix cervix NN cord-010092-uftc8inx 11510 19 , , , cord-010092-uftc8inx 11510 20 the the DT cord-010092-uftc8inx 11510 21 patient patient NN cord-010092-uftc8inx 11510 22 suffers suffer VBZ cord-010092-uftc8inx 11510 23 a a DT cord-010092-uftc8inx 11510 24 haemorrhagic haemorrhagic JJ cord-010092-uftc8inx 11510 25 shock shock NN cord-010092-uftc8inx 11510 26 with with IN cord-010092-uftc8inx 11510 27 multiple multiple JJ cord-010092-uftc8inx 11510 28 transfusion transfusion NN cord-010092-uftc8inx 11510 29 support support NN cord-010092-uftc8inx 11510 30 and and CC cord-010092-uftc8inx 11510 31 around around IN cord-010092-uftc8inx 11510 32 six six CD cord-010092-uftc8inx 11510 33 months month NNS cord-010092-uftc8inx 11510 34 later later RB cord-010092-uftc8inx 11510 35 undergoes undergo VBZ cord-010092-uftc8inx 11510 36 an an DT cord-010092-uftc8inx 11510 37 ureteronephrectomy ureteronephrectomy NN cord-010092-uftc8inx 11510 38 also also RB cord-010092-uftc8inx 11510 39 with with IN cord-010092-uftc8inx 11510 40 the the DT cord-010092-uftc8inx 11510 41 need need NN cord-010092-uftc8inx 11510 42 for for IN cord-010092-uftc8inx 11510 43 post post JJ cord-010092-uftc8inx 11510 44 - - JJ cord-010092-uftc8inx 11510 45 surgery surgery JJ cord-010092-uftc8inx 11510 46 transfusion transfusion NN cord-010092-uftc8inx 11510 47 support support NN cord-010092-uftc8inx 11510 48 . . . cord-010092-uftc8inx 11511 1 The the DT cord-010092-uftc8inx 11511 2 patient patient NN cord-010092-uftc8inx 11511 3 is be VBZ cord-010092-uftc8inx 11511 4 referred refer VBN cord-010092-uftc8inx 11511 5 to to IN cord-010092-uftc8inx 11511 6 the the DT cord-010092-uftc8inx 11511 7 Immunohemotherapy Immunohemotherapy NNP cord-010092-uftc8inx 11511 8 Department Department NNP cord-010092-uftc8inx 11511 9 where where WRB cord-010092-uftc8inx 11511 10 she -PRON- PRP cord-010092-uftc8inx 11511 11 has have VBZ cord-010092-uftc8inx 11511 12 regular regular JJ cord-010092-uftc8inx 11511 13 appointments appointment NNS cord-010092-uftc8inx 11511 14 as as IN cord-010092-uftc8inx 11511 15 an an DT cord-010092-uftc8inx 11511 16 outpatient outpatient NN cord-010092-uftc8inx 11511 17 since since IN cord-010092-uftc8inx 11511 18 2009 2009 CD cord-010092-uftc8inx 11511 19 . . . cord-010092-uftc8inx 11512 1 In in IN cord-010092-uftc8inx 11512 2 2012 2012 CD cord-010092-uftc8inx 11512 3 , , , cord-010092-uftc8inx 11512 4 she -PRON- PRP cord-010092-uftc8inx 11512 5 requires require VBZ cord-010092-uftc8inx 11512 6 surgery surgery NN cord-010092-uftc8inx 11512 7 for for IN cord-010092-uftc8inx 11512 8 the the DT cord-010092-uftc8inx 11512 9 removal removal NN cord-010092-uftc8inx 11512 10 of of IN cord-010092-uftc8inx 11512 11 a a DT cord-010092-uftc8inx 11512 12 thyroglossal thyroglossal NN cord-010092-uftc8inx 11512 13 duct duct NN cord-010092-uftc8inx 11512 14 cyst cyst NN cord-010092-uftc8inx 11512 15 , , , cord-010092-uftc8inx 11512 16 which which WDT cord-010092-uftc8inx 11512 17 is be VBZ cord-010092-uftc8inx 11512 18 performed perform VBN cord-010092-uftc8inx 11512 19 under under IN cord-010092-uftc8inx 11512 20 prophylactic prophylactic JJ cord-010092-uftc8inx 11512 21 treatment treatment NN cord-010092-uftc8inx 11512 22 with with IN cord-010092-uftc8inx 11512 23 2000 2000 CD cord-010092-uftc8inx 11512 24 IU IU NNP cord-010092-uftc8inx 11512 25 recombinant recombinant JJ cord-010092-uftc8inx 11512 26 FIX fix NN cord-010092-uftc8inx 11512 27 ( ( -LRB- cord-010092-uftc8inx 11512 28 rFIX rfix NN cord-010092-uftc8inx 11512 29 ) ) -RRB- cord-010092-uftc8inx 11513 1 daily daily RB cord-010092-uftc8inx 11513 2 , , , cord-010092-uftc8inx 11513 3 for for IN cord-010092-uftc8inx 11513 4 four four CD cord-010092-uftc8inx 11513 5 days day NNS cord-010092-uftc8inx 11513 6 , , , cord-010092-uftc8inx 11513 7 and and CC cord-010092-uftc8inx 11513 8 up up IN cord-010092-uftc8inx 11513 9 to to TO cord-010092-uftc8inx 11513 10 48 48 CD cord-010092-uftc8inx 11513 11 h h NN cord-010092-uftc8inx 11513 12 after after IN cord-010092-uftc8inx 11513 13 discharge discharge NN cord-010092-uftc8inx 11513 14 maintaining maintain VBG cord-010092-uftc8inx 11513 15 basal basal NN cord-010092-uftc8inx 11513 16 levels level NNS cord-010092-uftc8inx 11513 17 of of IN cord-010092-uftc8inx 11513 18 FIX fix NN cord-010092-uftc8inx 11513 19 of of IN cord-010092-uftc8inx 11513 20 60 60 CD cord-010092-uftc8inx 11513 21 % % NN cord-010092-uftc8inx 11513 22 and and CC cord-010092-uftc8inx 11514 1 with with IN cord-010092-uftc8inx 11514 2 no no DT cord-010092-uftc8inx 11514 3 major major JJ cord-010092-uftc8inx 11514 4 complications complication NNS cord-010092-uftc8inx 11514 5 reported report VBN cord-010092-uftc8inx 11514 6 . . . cord-010092-uftc8inx 11515 1 In in IN cord-010092-uftc8inx 11515 2 2013 2013 CD cord-010092-uftc8inx 11515 3 , , , cord-010092-uftc8inx 11515 4 the the DT cord-010092-uftc8inx 11515 5 patient patient NN cord-010092-uftc8inx 11515 6 is be VBZ cord-010092-uftc8inx 11515 7 admitted admit VBN cord-010092-uftc8inx 11515 8 to to IN cord-010092-uftc8inx 11515 9 the the DT cord-010092-uftc8inx 11515 10 ER ER NNP cord-010092-uftc8inx 11515 11 in in IN cord-010092-uftc8inx 11515 12 haemodynamic haemodynamic JJ cord-010092-uftc8inx 11515 13 shock shock NN cord-010092-uftc8inx 11515 14 and and CC cord-010092-uftc8inx 11515 15 a a DT cord-010092-uftc8inx 11515 16 history history NN cord-010092-uftc8inx 11515 17 of of IN cord-010092-uftc8inx 11515 18 black black JJ cord-010092-uftc8inx 11515 19 stools stool NNS cord-010092-uftc8inx 11515 20 and and CC cord-010092-uftc8inx 11515 21 syncope syncope NN cord-010092-uftc8inx 11515 22 . . . cord-010092-uftc8inx 11516 1 At at IN cord-010092-uftc8inx 11516 2 admittance admittance NN cord-010092-uftc8inx 11516 3 , , , cord-010092-uftc8inx 11516 4 she -PRON- PRP cord-010092-uftc8inx 11516 5 receives receive VBZ cord-010092-uftc8inx 11516 6 a a DT cord-010092-uftc8inx 11516 7 bolus bolus NN cord-010092-uftc8inx 11516 8 of of IN cord-010092-uftc8inx 11516 9 4000 4000 CD cord-010092-uftc8inx 11516 10 IU IU NNP cord-010092-uftc8inx 11516 11 of of IN cord-010092-uftc8inx 11516 12 rFIX rfix NN cord-010092-uftc8inx 11516 13 and and CC cord-010092-uftc8inx 11516 14 requires require VBZ cord-010092-uftc8inx 11516 15 severe severe JJ cord-010092-uftc8inx 11516 16 transfusion transfusion NN cord-010092-uftc8inx 11516 17 support support NN cord-010092-uftc8inx 11516 18 due due IN cord-010092-uftc8inx 11516 19 to to IN cord-010092-uftc8inx 11516 20 active active JJ cord-010092-uftc8inx 11516 21 bleeding bleeding NN cord-010092-uftc8inx 11516 22 . . . cord-010092-uftc8inx 11517 1 She -PRON- PRP cord-010092-uftc8inx 11517 2 is be VBZ cord-010092-uftc8inx 11517 3 diagnosed diagnose VBN cord-010092-uftc8inx 11517 4 with with IN cord-010092-uftc8inx 11517 5 colonic colonic NNP cord-010092-uftc8inx 11517 6 angiodysplasia angiodysplasia NNP cord-010092-uftc8inx 11517 7 and and CC cord-010092-uftc8inx 11517 8 undergoes undergo VBZ cord-010092-uftc8inx 11517 9 surgery surgery NN cord-010092-uftc8inx 11517 10 . . . cord-010092-uftc8inx 11518 1 Daily daily JJ cord-010092-uftc8inx 11518 2 doses dose NNS cord-010092-uftc8inx 11518 3 of of IN cord-010092-uftc8inx 11518 4 3000 3000 CD cord-010092-uftc8inx 11518 5 IU IU NNP cord-010092-uftc8inx 11518 6 rFIX rfix NN cord-010092-uftc8inx 11518 7 are be VBP cord-010092-uftc8inx 11518 8 administered administer VBN cord-010092-uftc8inx 11518 9 from from IN cord-010092-uftc8inx 11518 10 day day NN cord-010092-uftc8inx 11518 11 1 1 CD cord-010092-uftc8inx 11518 12 ( ( -LRB- cord-010092-uftc8inx 11518 13 D1 D1 NNP cord-010092-uftc8inx 11518 14 ) ) -RRB- cord-010092-uftc8inx 11518 15 and and CC cord-010092-uftc8inx 11518 16 up up IN cord-010092-uftc8inx 11518 17 to to IN cord-010092-uftc8inx 11518 18 D7 d7 NN cord-010092-uftc8inx 11518 19 maintaining maintain VBG cord-010092-uftc8inx 11518 20 FIX fix NN cord-010092-uftc8inx 11518 21 levels level NNS cord-010092-uftc8inx 11518 22 around around IN cord-010092-uftc8inx 11518 23 60 60 CD cord-010092-uftc8inx 11518 24 - - SYM cord-010092-uftc8inx 11518 25 80 80 CD cord-010092-uftc8inx 11518 26 % % NN cord-010092-uftc8inx 11518 27 . . . cord-010092-uftc8inx 11519 1 The the DT cord-010092-uftc8inx 11519 2 patient patient NN cord-010092-uftc8inx 11519 3 is be VBZ cord-010092-uftc8inx 11519 4 operated operate VBN cord-010092-uftc8inx 11519 5 at at IN cord-010092-uftc8inx 11519 6 D8 D8 NNP cord-010092-uftc8inx 11519 7 under under IN cord-010092-uftc8inx 11519 8 the the DT cord-010092-uftc8inx 11519 9 cover cover NN cord-010092-uftc8inx 11519 10 of of IN cord-010092-uftc8inx 11519 11 2000 2000 CD cord-010092-uftc8inx 11519 12 IU IU NNP cord-010092-uftc8inx 11519 13 of of IN cord-010092-uftc8inx 11519 14 rFIX rfix NN cord-010092-uftc8inx 11519 15 , , , cord-010092-uftc8inx 11519 16 twice twice RB cord-010092-uftc8inx 11519 17 per per IN cord-010092-uftc8inx 11519 18 day day NN cord-010092-uftc8inx 11519 19 , , , cord-010092-uftc8inx 11519 20 and and CC cord-010092-uftc8inx 11519 21 up up IN cord-010092-uftc8inx 11519 22 to to IN cord-010092-uftc8inx 11519 23 D14 D14 NNP cord-010092-uftc8inx 11519 24 after after IN cord-010092-uftc8inx 11519 25 surgery surgery NN cord-010092-uftc8inx 11519 26 reaching reach VBG cord-010092-uftc8inx 11519 27 FIX fix NN cord-010092-uftc8inx 11519 28 levels level NNS cord-010092-uftc8inx 11519 29 of of IN cord-010092-uftc8inx 11519 30 around around IN cord-010092-uftc8inx 11519 31 80 80 CD cord-010092-uftc8inx 11519 32 - - SYM cord-010092-uftc8inx 11519 33 110 110 CD cord-010092-uftc8inx 11519 34 % % NN cord-010092-uftc8inx 11519 35 . . . cord-010092-uftc8inx 11520 1 At at IN cord-010092-uftc8inx 11520 2 D15 D15 NNP cord-010092-uftc8inx 11520 3 the the DT cord-010092-uftc8inx 11520 4 dose dose NN cord-010092-uftc8inx 11520 5 was be VBD cord-010092-uftc8inx 11520 6 diminished diminish VBN cord-010092-uftc8inx 11520 7 to to IN cord-010092-uftc8inx 11520 8 2000 2000 CD cord-010092-uftc8inx 11520 9 IU IU NNP cord-010092-uftc8inx 11520 10 of of IN cord-010092-uftc8inx 11520 11 rFIX rfix JJ cord-010092-uftc8inx 11520 12 daily daily RB cord-010092-uftc8inx 11520 13 and and CC cord-010092-uftc8inx 11520 14 at at IN cord-010092-uftc8inx 11520 15 D17 D17 NNP cord-010092-uftc8inx 11520 16 she -PRON- PRP cord-010092-uftc8inx 11520 17 is be VBZ cord-010092-uftc8inx 11520 18 discharged discharge VBN cord-010092-uftc8inx 11520 19 with with IN cord-010092-uftc8inx 11520 20 no no DT cord-010092-uftc8inx 11520 21 rFIX rfix NN cord-010092-uftc8inx 11520 22 replacement replacement NN cord-010092-uftc8inx 11520 23 therapy therapy NN cord-010092-uftc8inx 11520 24 necessary necessary JJ cord-010092-uftc8inx 11520 25 in in IN cord-010092-uftc8inx 11520 26 ambulatory ambulatory NN cord-010092-uftc8inx 11520 27 . . . cord-010092-uftc8inx 11521 1 Since since IN cord-010092-uftc8inx 11521 2 then then RB cord-010092-uftc8inx 11521 3 , , , cord-010092-uftc8inx 11521 4 no no DT cord-010092-uftc8inx 11521 5 complications complication NNS cord-010092-uftc8inx 11521 6 or or CC cord-010092-uftc8inx 11521 7 new new JJ cord-010092-uftc8inx 11521 8 occurrences occurrence NNS cord-010092-uftc8inx 11521 9 have have VBP cord-010092-uftc8inx 11521 10 been be VBN cord-010092-uftc8inx 11521 11 reported report VBN cord-010092-uftc8inx 11521 12 . . . cord-010092-uftc8inx 11522 1 The the DT cord-010092-uftc8inx 11522 2 patient patient NN cord-010092-uftc8inx 11522 3 is be VBZ cord-010092-uftc8inx 11522 4 under under IN cord-010092-uftc8inx 11522 5 prophylactic prophylactic JJ cord-010092-uftc8inx 11522 6 administration administration NN cord-010092-uftc8inx 11522 7 of of IN cord-010092-uftc8inx 11522 8 rFIX rFIX NNP cord-010092-uftc8inx 11522 9 prior prior RB cord-010092-uftc8inx 11522 10 to to IN cord-010092-uftc8inx 11522 11 minor minor JJ cord-010092-uftc8inx 11522 12 invasive invasive JJ cord-010092-uftc8inx 11522 13 procedures procedure NNS cord-010092-uftc8inx 11522 14 ( ( -LRB- cord-010092-uftc8inx 11522 15 nodule nodule NN cord-010092-uftc8inx 11522 16 biopsy biopsy NN cord-010092-uftc8inx 11522 17 , , , cord-010092-uftc8inx 11522 18 dental dental JJ cord-010092-uftc8inx 11522 19 extractions extraction NNS cord-010092-uftc8inx 11522 20 and and CC cord-010092-uftc8inx 11522 21 colonoscopies colonoscopy NNS cord-010092-uftc8inx 11522 22 ) ) -RRB- cord-010092-uftc8inx 11522 23 . . . cord-010092-uftc8inx 11523 1 Summary Summary NNP cord-010092-uftc8inx 11523 2 / / SYM cord-010092-uftc8inx 11523 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 11523 4 : : : cord-010092-uftc8inx 11524 1 Hemophilia Hemophilia NNP cord-010092-uftc8inx 11524 2 B b NN cord-010092-uftc8inx 11524 3 carriers carrier NNS cord-010092-uftc8inx 11524 4 usually usually RB cord-010092-uftc8inx 11524 5 do do VBP cord-010092-uftc8inx 11524 6 not not RB cord-010092-uftc8inx 11524 7 require require VB cord-010092-uftc8inx 11524 8 any any DT cord-010092-uftc8inx 11524 9 major major JJ cord-010092-uftc8inx 11524 10 health health NN cord-010092-uftc8inx 11524 11 care care NN cord-010092-uftc8inx 11524 12 for for IN cord-010092-uftc8inx 11524 13 their -PRON- PRP$ cord-010092-uftc8inx 11524 14 daily daily JJ cord-010092-uftc8inx 11524 15 routine routine JJ cord-010092-uftc8inx 11524 16 or or CC cord-010092-uftc8inx 11524 17 invasive invasive JJ cord-010092-uftc8inx 11524 18 procedures procedure NNS cord-010092-uftc8inx 11524 19 . . . cord-010092-uftc8inx 11525 1 However however RB cord-010092-uftc8inx 11525 2 , , , cord-010092-uftc8inx 11525 3 in in IN cord-010092-uftc8inx 11525 4 the the DT cord-010092-uftc8inx 11525 5 case case NN cord-010092-uftc8inx 11525 6 reported report VBN cord-010092-uftc8inx 11525 7 , , , cord-010092-uftc8inx 11525 8 basal basal JJ cord-010092-uftc8inx 11525 9 FIX fix NN cord-010092-uftc8inx 11525 10 levels level NNS cord-010092-uftc8inx 11525 11 conditioned condition VBD cord-010092-uftc8inx 11525 12 any any DT cord-010092-uftc8inx 11525 13 minor minor JJ cord-010092-uftc8inx 11525 14 intervention intervention NN cord-010092-uftc8inx 11525 15 to to TO cord-010092-uftc8inx 11525 16 be be VB cord-010092-uftc8inx 11525 17 performed perform VBN cord-010092-uftc8inx 11525 18 . . . cord-010092-uftc8inx 11526 1 Thus thus RB cord-010092-uftc8inx 11526 2 , , , cord-010092-uftc8inx 11526 3 this this DT cord-010092-uftc8inx 11526 4 carrier carrier NN cord-010092-uftc8inx 11526 5 must must MD cord-010092-uftc8inx 11526 6 be be VB cord-010092-uftc8inx 11526 7 considered consider VBN cord-010092-uftc8inx 11526 8 as as IN cord-010092-uftc8inx 11526 9 a a DT cord-010092-uftc8inx 11526 10 moderate moderate JJ cord-010092-uftc8inx 11526 11 Hemophilia Hemophilia NNP cord-010092-uftc8inx 11526 12 B B NNP cord-010092-uftc8inx 11526 13 patient patient NN cord-010092-uftc8inx 11526 14 and and CC cord-010092-uftc8inx 11526 15 mandatory mandatory JJ cord-010092-uftc8inx 11526 16 prophylaxis prophylaxis NN cord-010092-uftc8inx 11526 17 with with IN cord-010092-uftc8inx 11526 18 rFIX rfix NN cord-010092-uftc8inx 11526 19 must must MD cord-010092-uftc8inx 11526 20 be be VB cord-010092-uftc8inx 11526 21 performed perform VBN cord-010092-uftc8inx 11526 22 prior prior RB cord-010092-uftc8inx 11526 23 to to IN cord-010092-uftc8inx 11526 24 any any DT cord-010092-uftc8inx 11526 25 invasive invasive JJ cord-010092-uftc8inx 11526 26 procedure procedure NN cord-010092-uftc8inx 11526 27 . . . cord-010092-uftc8inx 11527 1 Background background NN cord-010092-uftc8inx 11527 2 : : : cord-010092-uftc8inx 11528 1 Blood blood NN cord-010092-uftc8inx 11528 2 transfusion transfusion NN cord-010092-uftc8inx 11528 3 is be VBZ cord-010092-uftc8inx 11528 4 a a DT cord-010092-uftc8inx 11528 5 life life NN cord-010092-uftc8inx 11528 6 saving save VBG cord-010092-uftc8inx 11528 7 procedure procedure NN cord-010092-uftc8inx 11528 8 but but CC cord-010092-uftc8inx 11528 9 transfusion transfusion NN cord-010092-uftc8inx 11528 10 associated associate VBD cord-010092-uftc8inx 11528 11 complications complication NNS cord-010092-uftc8inx 11528 12 are be VBP cord-010092-uftc8inx 11528 13 equally equally RB cord-010092-uftc8inx 11528 14 important important JJ cord-010092-uftc8inx 11528 15 that that WDT cord-010092-uftc8inx 11528 16 need need VBP cord-010092-uftc8inx 11528 17 to to TO cord-010092-uftc8inx 11528 18 be be VB cord-010092-uftc8inx 11528 19 addressed address VBN cord-010092-uftc8inx 11528 20 . . . cord-010092-uftc8inx 11529 1 With with IN cord-010092-uftc8inx 11529 2 limited limited JJ cord-010092-uftc8inx 11529 3 resources resource NNS cord-010092-uftc8inx 11529 4 of of IN cord-010092-uftc8inx 11529 5 blood blood NN cord-010092-uftc8inx 11529 6 donations donation NNS cord-010092-uftc8inx 11529 7 and and CC cord-010092-uftc8inx 11529 8 screening screening NN cord-010092-uftc8inx 11529 9 , , , cord-010092-uftc8inx 11529 10 excessive excessive JJ cord-010092-uftc8inx 11529 11 transfusions transfusion NNS cord-010092-uftc8inx 11529 12 must must MD cord-010092-uftc8inx 11529 13 be be VB cord-010092-uftc8inx 11529 14 avoided avoid VBN cord-010092-uftc8inx 11529 15 to to TO cord-010092-uftc8inx 11529 16 prevent prevent VB cord-010092-uftc8inx 11529 17 risk risk NN cord-010092-uftc8inx 11529 18 and and CC cord-010092-uftc8inx 11529 19 economic economic JJ cord-010092-uftc8inx 11529 20 burden burden NN cord-010092-uftc8inx 11529 21 on on IN cord-010092-uftc8inx 11529 22 patients patient NNS cord-010092-uftc8inx 11529 23 . . . cord-010092-uftc8inx 11530 1 On on IN cord-010092-uftc8inx 11530 2 the the DT cord-010092-uftc8inx 11530 3 other other JJ cord-010092-uftc8inx 11530 4 hand hand NN cord-010092-uftc8inx 11530 5 discussion discussion NN cord-010092-uftc8inx 11530 6 on on IN cord-010092-uftc8inx 11530 7 appropriate appropriate JJ cord-010092-uftc8inx 11530 8 use use NN cord-010092-uftc8inx 11530 9 of of IN cord-010092-uftc8inx 11530 10 blood blood NN cord-010092-uftc8inx 11530 11 product product NN cord-010092-uftc8inx 11530 12 is be VBZ cord-010092-uftc8inx 11530 13 a a DT cord-010092-uftc8inx 11530 14 matter matter NN cord-010092-uftc8inx 11530 15 of of IN cord-010092-uftc8inx 11530 16 debate debate NN cord-010092-uftc8inx 11530 17 in in IN cord-010092-uftc8inx 11530 18 medical medical JJ cord-010092-uftc8inx 11530 19 literature literature NN cord-010092-uftc8inx 11530 20 . . . cord-010092-uftc8inx 11531 1 It -PRON- PRP cord-010092-uftc8inx 11531 2 is be VBZ cord-010092-uftc8inx 11531 3 recommended recommend VBN cord-010092-uftc8inx 11531 4 to to TO cord-010092-uftc8inx 11531 5 restrict restrict VB cord-010092-uftc8inx 11531 6 the the DT cord-010092-uftc8inx 11531 7 liberal liberal JJ cord-010092-uftc8inx 11531 8 use use NN cord-010092-uftc8inx 11531 9 of of IN cord-010092-uftc8inx 11531 10 transfusion transfusion NN cord-010092-uftc8inx 11531 11 . . . cord-010092-uftc8inx 11532 1 Aims aim VBZ cord-010092-uftc8inx 11532 2 : : : cord-010092-uftc8inx 11533 1 In in IN cord-010092-uftc8inx 11533 2 this this DT cord-010092-uftc8inx 11533 3 regard regard NN cord-010092-uftc8inx 11533 4 we -PRON- PRP cord-010092-uftc8inx 11533 5 aimed aim VBD cord-010092-uftc8inx 11533 6 to to TO cord-010092-uftc8inx 11533 7 observe observe VB cord-010092-uftc8inx 11533 8 the the DT cord-010092-uftc8inx 11533 9 frequency frequency NN cord-010092-uftc8inx 11533 10 of of IN cord-010092-uftc8inx 11533 11 genuine genuine JJ cord-010092-uftc8inx 11533 12 and and CC cord-010092-uftc8inx 11533 13 non non JJ cord-010092-uftc8inx 11533 14 genuine genuine JJ cord-010092-uftc8inx 11533 15 transfusion transfusion NN cord-010092-uftc8inx 11533 16 at at IN cord-010092-uftc8inx 11533 17 our -PRON- PRP$ cord-010092-uftc8inx 11533 18 hospital hospital NN cord-010092-uftc8inx 11533 19 and and CC cord-010092-uftc8inx 11533 20 also also RB cord-010092-uftc8inx 11533 21 to to TO cord-010092-uftc8inx 11533 22 compare compare VB cord-010092-uftc8inx 11533 23 the the DT cord-010092-uftc8inx 11533 24 outcomes outcome NNS cord-010092-uftc8inx 11533 25 of of IN cord-010092-uftc8inx 11533 26 liberal liberal JJ cord-010092-uftc8inx 11533 27 and and CC cord-010092-uftc8inx 11533 28 restrictive restrictive JJ cord-010092-uftc8inx 11533 29 transfusions transfusion NNS cord-010092-uftc8inx 11533 30 . . . cord-010092-uftc8inx 11534 1 Methods method NNS cord-010092-uftc8inx 11534 2 : : : cord-010092-uftc8inx 11534 3 It -PRON- PRP cord-010092-uftc8inx 11534 4 was be VBD cord-010092-uftc8inx 11534 5 a a DT cord-010092-uftc8inx 11534 6 cross cross JJ cord-010092-uftc8inx 11534 7 sectional sectional JJ cord-010092-uftc8inx 11534 8 study study NN cord-010092-uftc8inx 11534 9 carried carry VBD cord-010092-uftc8inx 11534 10 out out RP cord-010092-uftc8inx 11534 11 at at IN cord-010092-uftc8inx 11534 12 NIBD NIBD NNP cord-010092-uftc8inx 11534 13 and and CC cord-010092-uftc8inx 11534 14 BMT BMT NNP cord-010092-uftc8inx 11534 15 , , , cord-010092-uftc8inx 11534 16 PECHS PECHS NNP cord-010092-uftc8inx 11534 17 campus campus NN cord-010092-uftc8inx 11534 18 , , , cord-010092-uftc8inx 11534 19 Karachi Karachi NNP cord-010092-uftc8inx 11534 20 , , , cord-010092-uftc8inx 11534 21 Pakistan Pakistan NNP cord-010092-uftc8inx 11534 22 , , , cord-010092-uftc8inx 11534 23 from from IN cord-010092-uftc8inx 11534 24 February February NNP cord-010092-uftc8inx 11534 25 2018 2018 CD cord-010092-uftc8inx 11534 26 to to IN cord-010092-uftc8inx 11534 27 January January NNP cord-010092-uftc8inx 11534 28 2019 2019 CD cord-010092-uftc8inx 11534 29 . . . cord-010092-uftc8inx 11535 1 The the DT cord-010092-uftc8inx 11535 2 study study NN cord-010092-uftc8inx 11535 3 was be VBD cord-010092-uftc8inx 11535 4 approved approve VBN cord-010092-uftc8inx 11535 5 from from IN cord-010092-uftc8inx 11535 6 institutional institutional JJ cord-010092-uftc8inx 11535 7 review review NNP cord-010092-uftc8inx 11535 8 board board NN cord-010092-uftc8inx 11535 9 . . . cord-010092-uftc8inx 11536 1 Pack pack VB cord-010092-uftc8inx 11536 2 red red JJ cord-010092-uftc8inx 11536 3 cells cell NNS cord-010092-uftc8inx 11536 4 ( ( -LRB- cord-010092-uftc8inx 11536 5 PRC PRC NNP cord-010092-uftc8inx 11536 6 ) ) -RRB- cord-010092-uftc8inx 11536 7 transfusion transfusion NN cord-010092-uftc8inx 11536 8 in in IN cord-010092-uftc8inx 11536 9 case case NN cord-010092-uftc8inx 11536 10 of of IN cord-010092-uftc8inx 11536 11 < < NNP cord-010092-uftc8inx 11536 12 7 7 CD cord-010092-uftc8inx 11536 13 g g NN cord-010092-uftc8inx 11536 14 / / SYM cord-010092-uftc8inx 11536 15 dl dl NN cord-010092-uftc8inx 11536 16 hemoglobin hemoglobin NN cord-010092-uftc8inx 11536 17 ( ( -LRB- cord-010092-uftc8inx 11536 18 Hb Hb NNP cord-010092-uftc8inx 11536 19 ) ) -RRB- cord-010092-uftc8inx 11536 20 with with IN cord-010092-uftc8inx 11536 21 cardiac cardiac JJ cord-010092-uftc8inx 11536 22 history history NN cord-010092-uftc8inx 11536 23 and and CC cord-010092-uftc8inx 11536 24 < < XX cord-010092-uftc8inx 11536 25 7 7 CD cord-010092-uftc8inx 11536 26 g g NN cord-010092-uftc8inx 11536 27 / / SYM cord-010092-uftc8inx 11536 28 dl dl NNP cord-010092-uftc8inx 11536 29 Hb Hb NNP cord-010092-uftc8inx 11536 30 with with IN cord-010092-uftc8inx 11536 31 symptomatic symptomatic JJ cord-010092-uftc8inx 11536 32 anemia anemia NN cord-010092-uftc8inx 11536 33 was be VBD cord-010092-uftc8inx 11536 34 considered consider VBN cord-010092-uftc8inx 11536 35 genuine genuine JJ cord-010092-uftc8inx 11536 36 . . . cord-010092-uftc8inx 11537 1 Platelets platelet NNS cord-010092-uftc8inx 11537 2 transfusion transfusion NN cord-010092-uftc8inx 11537 3 in in IN cord-010092-uftc8inx 11537 4 case case NN cord-010092-uftc8inx 11537 5 of of IN cord-010092-uftc8inx 11537 6 sepsis sepsis NN cord-010092-uftc8inx 11537 7 and and CC cord-010092-uftc8inx 11537 8 count count VB cord-010092-uftc8inx 11537 9 < < XX cord-010092-uftc8inx 11537 10 50 50 CD cord-010092-uftc8inx 11537 11 9 9 CD cord-010092-uftc8inx 11537 12 10 10 CD cord-010092-uftc8inx 11537 13 9 9 CD cord-010092-uftc8inx 11537 14 /L /l CD cord-010092-uftc8inx 11537 15 , , , cord-010092-uftc8inx 11537 16 sepsis sepsis NN cord-010092-uftc8inx 11537 17 with with IN cord-010092-uftc8inx 11537 18 bleeding bleeding NN cord-010092-uftc8inx 11537 19 and and CC cord-010092-uftc8inx 11537 20 < < XX cord-010092-uftc8inx 11537 21 100 100 CD cord-010092-uftc8inx 11537 22 9 9 CD cord-010092-uftc8inx 11537 23 10 10 CD cord-010092-uftc8inx 11537 24 9 9 CD cord-010092-uftc8inx 11537 25 /L /l CD cord-010092-uftc8inx 11537 26 , , , cord-010092-uftc8inx 11537 27 patients patient NNS cord-010092-uftc8inx 11537 28 on on IN cord-010092-uftc8inx 11537 29 active active JJ cord-010092-uftc8inx 11537 30 chemotherapy chemotherapy NN cord-010092-uftc8inx 11537 31 without without IN cord-010092-uftc8inx 11537 32 bleeding bleed VBG cord-010092-uftc8inx 11537 33 but but CC cord-010092-uftc8inx 11537 34 platelet platelet NN cord-010092-uftc8inx 11537 35 count count NN cord-010092-uftc8inx 11537 36 < < XX cord-010092-uftc8inx 11537 37 10 10 CD cord-010092-uftc8inx 11537 38 9 9 CD cord-010092-uftc8inx 11537 39 10 10 CD cord-010092-uftc8inx 11537 40 9 9 CD cord-010092-uftc8inx 11537 41 /L /L . cord-010092-uftc8inx 11537 42 and and CC cord-010092-uftc8inx 11537 43 in in IN cord-010092-uftc8inx 11537 44 patients patient NNS cord-010092-uftc8inx 11537 45 presented present VBN cord-010092-uftc8inx 11537 46 with with IN cord-010092-uftc8inx 11537 47 bleeding bleed VBG cord-010092-uftc8inx 11537 48 was be VBD cord-010092-uftc8inx 11537 49 considered consider VBN cord-010092-uftc8inx 11537 50 genuine genuine JJ cord-010092-uftc8inx 11537 51 . . . cord-010092-uftc8inx 11538 1 Patients patient NNS cord-010092-uftc8inx 11538 2 who who WP cord-010092-uftc8inx 11538 3 were be VBD cord-010092-uftc8inx 11538 4 presented present VBN cord-010092-uftc8inx 11538 5 with with IN cord-010092-uftc8inx 11538 6 bleeding bleed VBG cord-010092-uftc8inx 11538 7 , , , cord-010092-uftc8inx 11538 8 deranged deranged JJ cord-010092-uftc8inx 11538 9 coagulation coagulation NN cord-010092-uftc8inx 11538 10 profile profile NN cord-010092-uftc8inx 11538 11 and and CC cord-010092-uftc8inx 11538 12 with with IN cord-010092-uftc8inx 11538 13 sepsis sepsis NN cord-010092-uftc8inx 11538 14 + + CC cord-010092-uftc8inx 11538 15 bleeding bleeding NN cord-010092-uftc8inx 11538 16 considered consider VBN cord-010092-uftc8inx 11538 17 genuine genuine JJ cord-010092-uftc8inx 11538 18 for for IN cord-010092-uftc8inx 11538 19 fresh fresh JJ cord-010092-uftc8inx 11538 20 frozen frozen JJ cord-010092-uftc8inx 11538 21 plasma plasma NN cord-010092-uftc8inx 11538 22 ( ( -LRB- cord-010092-uftc8inx 11538 23 FFP FFP NNP cord-010092-uftc8inx 11538 24 ) ) -RRB- cord-010092-uftc8inx 11538 25 transfusion transfusion NN cord-010092-uftc8inx 11538 26 . . . cord-010092-uftc8inx 11539 1 SPSS SPSS NNP cord-010092-uftc8inx 11539 2 version version NN cord-010092-uftc8inx 11539 3 23.0 23.0 CD cord-010092-uftc8inx 11539 4 was be VBD cord-010092-uftc8inx 11539 5 used use VBN cord-010092-uftc8inx 11539 6 for for IN cord-010092-uftc8inx 11539 7 descriptive descriptive JJ cord-010092-uftc8inx 11539 8 and and CC cord-010092-uftc8inx 11539 9 inferential inferential JJ cord-010092-uftc8inx 11539 10 statistics statistic NNS cord-010092-uftc8inx 11539 11 . . . cord-010092-uftc8inx 11540 1 Results result NNS cord-010092-uftc8inx 11540 2 : : : cord-010092-uftc8inx 11541 1 A a DT cord-010092-uftc8inx 11541 2 total total NN cord-010092-uftc8inx 11541 3 of of IN cord-010092-uftc8inx 11541 4 250 250 CD cord-010092-uftc8inx 11541 5 transfusions transfusion NNS cord-010092-uftc8inx 11541 6 were be VBD cord-010092-uftc8inx 11541 7 evaluated evaluate VBN cord-010092-uftc8inx 11541 8 for for IN cord-010092-uftc8inx 11541 9 genuine genuine JJ cord-010092-uftc8inx 11541 10 and and CC cord-010092-uftc8inx 11541 11 non non JJ cord-010092-uftc8inx 11541 12 genuine genuine JJ cord-010092-uftc8inx 11541 13 transfusion transfusion NN cord-010092-uftc8inx 11541 14 . . . cord-010092-uftc8inx 11542 1 Male male JJ cord-010092-uftc8inx 11542 2 predominance predominance NN cord-010092-uftc8inx 11542 3 was be VBD cord-010092-uftc8inx 11542 4 high high JJ cord-010092-uftc8inx 11542 5 in in IN cord-010092-uftc8inx 11542 6 our -PRON- PRP$ cord-010092-uftc8inx 11542 7 data datum NNS cord-010092-uftc8inx 11542 8 194(78 194(78 CD cord-010092-uftc8inx 11542 9 % % NN cord-010092-uftc8inx 11542 10 ) ) -RRB- cord-010092-uftc8inx 11542 11 . . . cord-010092-uftc8inx 11543 1 Out out IN cord-010092-uftc8inx 11543 2 of of IN cord-010092-uftc8inx 11543 3 250 250 CD cord-010092-uftc8inx 11543 4 , , , cord-010092-uftc8inx 11543 5 134 134 CD cord-010092-uftc8inx 11543 6 ( ( -LRB- cord-010092-uftc8inx 11543 7 54 54 CD cord-010092-uftc8inx 11543 8 % % NN cord-010092-uftc8inx 11543 9 ) ) -RRB- cord-010092-uftc8inx 11543 10 , , , cord-010092-uftc8inx 11543 11 100(40 100(40 CD cord-010092-uftc8inx 11543 12 % % NN cord-010092-uftc8inx 11543 13 ) ) -RRB- cord-010092-uftc8inx 11543 14 and and CC cord-010092-uftc8inx 11543 15 16(6 16(6 CD cord-010092-uftc8inx 11543 16 % % NN cord-010092-uftc8inx 11543 17 ) ) -RRB- cord-010092-uftc8inx 11544 1 PRCs PRCs NNPS cord-010092-uftc8inx 11544 2 , , , cord-010092-uftc8inx 11544 3 Platelets Platelets NNPS cord-010092-uftc8inx 11544 4 and and CC cord-010092-uftc8inx 11544 5 FFP FFP NNP cord-010092-uftc8inx 11544 6 were be VBD cord-010092-uftc8inx 11544 7 transfused transfuse VBN cord-010092-uftc8inx 11544 8 respectively respectively RB cord-010092-uftc8inx 11544 9 . . . cord-010092-uftc8inx 11545 1 Out out IN cord-010092-uftc8inx 11545 2 of of IN cord-010092-uftc8inx 11545 3 100 100 CD cord-010092-uftc8inx 11545 4 platelets platelet NNS cord-010092-uftc8inx 11545 5 , , , cord-010092-uftc8inx 11545 6 10(10 10(10 CD cord-010092-uftc8inx 11545 7 % % NN cord-010092-uftc8inx 11545 8 ) ) -RRB- cord-010092-uftc8inx 11545 9 were be VBD cord-010092-uftc8inx 11545 10 platelet platelet NN cord-010092-uftc8inx 11545 11 apheresis apheresis NN cord-010092-uftc8inx 11545 12 . . . cord-010092-uftc8inx 11546 1 80/134 80/134 CD cord-010092-uftc8inx 11546 2 ( ( -LRB- cord-010092-uftc8inx 11546 3 60 60 CD cord-010092-uftc8inx 11546 4 % % NN cord-010092-uftc8inx 11546 5 ) ) -RRB- cord-010092-uftc8inx 11547 1 PRCs PRCs NNPS cord-010092-uftc8inx 11547 2 and and CC cord-010092-uftc8inx 11547 3 22/90 22/90 CD cord-010092-uftc8inx 11547 4 ( ( -LRB- cord-010092-uftc8inx 11547 5 24 24 CD cord-010092-uftc8inx 11547 6 % % NN cord-010092-uftc8inx 11547 7 ) ) -RRB- cord-010092-uftc8inx 11548 1 platelets platelet NNS cord-010092-uftc8inx 11548 2 were be VBD cord-010092-uftc8inx 11548 3 non non JJ cord-010092-uftc8inx 11548 4 genuinely genuinely RB cord-010092-uftc8inx 11548 5 transfused transfuse VBN cord-010092-uftc8inx 11548 6 as as IN cord-010092-uftc8inx 11548 7 per per IN cord-010092-uftc8inx 11548 8 the the DT cord-010092-uftc8inx 11548 9 criteria criterion NNS cord-010092-uftc8inx 11548 10 described describe VBN cord-010092-uftc8inx 11548 11 in in IN cord-010092-uftc8inx 11548 12 methods method NNS cord-010092-uftc8inx 11548 13 . . . cord-010092-uftc8inx 11549 1 However however RB cord-010092-uftc8inx 11549 2 , , , cord-010092-uftc8inx 11549 3 FFP FFP NNP cord-010092-uftc8inx 11549 4 and and CC cord-010092-uftc8inx 11549 5 platelet platelet NN cord-010092-uftc8inx 11549 6 apheresis apheresis NN cord-010092-uftc8inx 11549 7 were be VBD cord-010092-uftc8inx 11549 8 genuinely genuinely RB cord-010092-uftc8inx 11549 9 transfused transfuse VBN cord-010092-uftc8inx 11549 10 . . . cord-010092-uftc8inx 11550 1 In in IN cord-010092-uftc8inx 11550 2 non non JJ cord-010092-uftc8inx 11550 3 genuine genuine JJ cord-010092-uftc8inx 11550 4 group group NN cord-010092-uftc8inx 11550 5 of of IN cord-010092-uftc8inx 11550 6 platelet platelet NN cord-010092-uftc8inx 11550 7 transfusion transfusion NN cord-010092-uftc8inx 11550 8 , , , cord-010092-uftc8inx 11550 9 all all DT cord-010092-uftc8inx 11550 10 patients patient NNS cord-010092-uftc8inx 11550 11 received receive VBD cord-010092-uftc8inx 11550 12 more more JJR cord-010092-uftc8inx 11550 13 than than IN cord-010092-uftc8inx 11550 14 1 1 CD cord-010092-uftc8inx 11550 15 unit unit NN cord-010092-uftc8inx 11550 16 platelet platelet NN cord-010092-uftc8inx 11550 17 and and CC cord-010092-uftc8inx 11550 18 the the DT cord-010092-uftc8inx 11550 19 increment increment NN cord-010092-uftc8inx 11550 20 of of IN cord-010092-uftc8inx 11550 21 platelet platelet NN cord-010092-uftc8inx 11550 22 count count NN cord-010092-uftc8inx 11550 23 post post NN cord-010092-uftc8inx 11550 24 transfusion transfusion NN cord-010092-uftc8inx 11550 25 was be VBD cord-010092-uftc8inx 11550 26 found find VBN cord-010092-uftc8inx 11550 27 statistically statistically RB cord-010092-uftc8inx 11550 28 non non AFX cord-010092-uftc8inx 11550 29 significant significant JJ cord-010092-uftc8inx 11550 30 ( ( -LRB- cord-010092-uftc8inx 11550 31 P p NN cord-010092-uftc8inx 11550 32 = = SYM cord-010092-uftc8inx 11550 33 0.121 0.121 CD cord-010092-uftc8inx 11550 34 ) ) -RRB- cord-010092-uftc8inx 11550 35 . . . cord-010092-uftc8inx 11551 1 Thirty thirty CD cord-010092-uftc8inx 11551 2 six six CD cord-010092-uftc8inx 11551 3 ( ( -LRB- cord-010092-uftc8inx 11551 4 45 45 CD cord-010092-uftc8inx 11551 5 % % NN cord-010092-uftc8inx 11551 6 ) ) -RRB- cord-010092-uftc8inx 11551 7 of of IN cord-010092-uftc8inx 11551 8 transfusions transfusion NNS cord-010092-uftc8inx 11551 9 were be VBD cord-010092-uftc8inx 11551 10 done do VBN cord-010092-uftc8inx 11551 11 with with IN cord-010092-uftc8inx 11551 12 more more JJR cord-010092-uftc8inx 11551 13 than than IN cord-010092-uftc8inx 11551 14 1 1 CD cord-010092-uftc8inx 11551 15 units unit NNS cord-010092-uftc8inx 11551 16 of of IN cord-010092-uftc8inx 11551 17 PRCs PRCs NNPS cord-010092-uftc8inx 11551 18 in in IN cord-010092-uftc8inx 11551 19 non non JJ cord-010092-uftc8inx 11551 20 genuine genuine JJ cord-010092-uftc8inx 11551 21 group group NN cord-010092-uftc8inx 11551 22 . . . cord-010092-uftc8inx 11552 1 The the DT cord-010092-uftc8inx 11552 2 mean mean JJ cord-010092-uftc8inx 11552 3 Hb Hb NNP cord-010092-uftc8inx 11552 4 level level NN cord-010092-uftc8inx 11552 5 of of IN cord-010092-uftc8inx 11552 6 patients patient NNS cord-010092-uftc8inx 11552 7 received receive VBD cord-010092-uftc8inx 11552 8 1 1 CD cord-010092-uftc8inx 11552 9 unit unit NN cord-010092-uftc8inx 11552 10 and and CC cord-010092-uftc8inx 11552 11 more more JJR cord-010092-uftc8inx 11552 12 than than IN cord-010092-uftc8inx 11552 13 1 1 CD cord-010092-uftc8inx 11552 14 units unit NNS cord-010092-uftc8inx 11552 15 PRCs PRCs NNPS cord-010092-uftc8inx 11552 16 was be VBD cord-010092-uftc8inx 11552 17 statistically statistically RB cord-010092-uftc8inx 11552 18 same same JJ cord-010092-uftc8inx 11552 19 ( ( -LRB- cord-010092-uftc8inx 11552 20 P p NN cord-010092-uftc8inx 11552 21 = = SYM cord-010092-uftc8inx 11552 22 0.868 0.868 CD cord-010092-uftc8inx 11552 23 ) ) -RRB- cord-010092-uftc8inx 11552 24 and and CC cord-010092-uftc8inx 11552 25 it -PRON- PRP cord-010092-uftc8inx 11552 26 was be VBD cord-010092-uftc8inx 11552 27 found find VBN cord-010092-uftc8inx 11552 28 out out RP cord-010092-uftc8inx 11552 29 that that IN cord-010092-uftc8inx 11552 30 there there EX cord-010092-uftc8inx 11552 31 was be VBD cord-010092-uftc8inx 11552 32 same same JJ cord-010092-uftc8inx 11552 33 increment increment NN cord-010092-uftc8inx 11552 34 in in IN cord-010092-uftc8inx 11552 35 Hb Hb NNP cord-010092-uftc8inx 11552 36 in in IN cord-010092-uftc8inx 11552 37 both both CC cord-010092-uftc8inx 11552 38 the the DT cord-010092-uftc8inx 11552 39 groups group NNS cord-010092-uftc8inx 11552 40 post post VBP cord-010092-uftc8inx 11552 41 transfusion transfusion NN cord-010092-uftc8inx 11552 42 . . . cord-010092-uftc8inx 11553 1 ( ( -LRB- cord-010092-uftc8inx 11553 2 P p NN cord-010092-uftc8inx 11553 3 = = SYM cord-010092-uftc8inx 11553 4 0.867 0.867 CD cord-010092-uftc8inx 11553 5 ) ) -RRB- cord-010092-uftc8inx 11553 6 . . . cord-010092-uftc8inx 11554 1 Summary Summary NNP cord-010092-uftc8inx 11554 2 / / SYM cord-010092-uftc8inx 11554 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 11554 4 : : : cord-010092-uftc8inx 11555 1 We -PRON- PRP cord-010092-uftc8inx 11555 2 concluded conclude VBD cord-010092-uftc8inx 11555 3 that that IN cord-010092-uftc8inx 11555 4 although although IN cord-010092-uftc8inx 11555 5 blood blood NN cord-010092-uftc8inx 11555 6 transfusion transfusion NN cord-010092-uftc8inx 11555 7 is be VBZ cord-010092-uftc8inx 11555 8 an an DT cord-010092-uftc8inx 11555 9 integral integral JJ cord-010092-uftc8inx 11555 10 procedure procedure NN cord-010092-uftc8inx 11555 11 for for IN cord-010092-uftc8inx 11555 12 saving save VBG cord-010092-uftc8inx 11555 13 life life NN cord-010092-uftc8inx 11555 14 yet yet CC cord-010092-uftc8inx 11555 15 correct correct JJ cord-010092-uftc8inx 11555 16 use use NN cord-010092-uftc8inx 11555 17 of of IN cord-010092-uftc8inx 11555 18 blood blood NN cord-010092-uftc8inx 11555 19 products product NNS cord-010092-uftc8inx 11555 20 is be VBZ cord-010092-uftc8inx 11555 21 necessary necessary JJ cord-010092-uftc8inx 11555 22 in in IN cord-010092-uftc8inx 11555 23 the the DT cord-010092-uftc8inx 11555 24 era era NN cord-010092-uftc8inx 11555 25 where where WRB cord-010092-uftc8inx 11555 26 blood blood NN cord-010092-uftc8inx 11555 27 donations donation NNS cord-010092-uftc8inx 11555 28 are be VBP cord-010092-uftc8inx 11555 29 scarce scarce JJ cord-010092-uftc8inx 11555 30 and and CC cord-010092-uftc8inx 11555 31 blood blood NN cord-010092-uftc8inx 11555 32 transfusion transfusion NN cord-010092-uftc8inx 11555 33 has have VBZ cord-010092-uftc8inx 11555 34 its -PRON- PRP$ cord-010092-uftc8inx 11555 35 potential potential JJ cord-010092-uftc8inx 11555 36 associated associate VBN cord-010092-uftc8inx 11555 37 hazards hazard NNS cord-010092-uftc8inx 11555 38 . . . cord-010092-uftc8inx 11556 1 The the DT cord-010092-uftc8inx 11556 2 approach approach NN cord-010092-uftc8inx 11556 3 towards towards IN cord-010092-uftc8inx 11556 4 the the DT cord-010092-uftc8inx 11556 5 appropriate appropriate JJ cord-010092-uftc8inx 11556 6 use use NN cord-010092-uftc8inx 11556 7 of of IN cord-010092-uftc8inx 11556 8 blood blood NN cord-010092-uftc8inx 11556 9 products product NNS cord-010092-uftc8inx 11556 10 will will MD cord-010092-uftc8inx 11556 11 not not RB cord-010092-uftc8inx 11556 12 only only RB cord-010092-uftc8inx 11556 13 minimize minimize VB cord-010092-uftc8inx 11556 14 the the DT cord-010092-uftc8inx 11556 15 risk risk NN cord-010092-uftc8inx 11556 16 of of IN cord-010092-uftc8inx 11556 17 transmission transmission NN cord-010092-uftc8inx 11556 18 of of IN cord-010092-uftc8inx 11556 19 infectious infectious JJ cord-010092-uftc8inx 11556 20 diseases disease NNS cord-010092-uftc8inx 11556 21 but but CC cord-010092-uftc8inx 11556 22 also also RB cord-010092-uftc8inx 11556 23 will will MD cord-010092-uftc8inx 11556 24 reduce reduce VB cord-010092-uftc8inx 11556 25 the the DT cord-010092-uftc8inx 11556 26 economic economic JJ cord-010092-uftc8inx 11556 27 burden burden NN cord-010092-uftc8inx 11556 28 . . . cord-010092-uftc8inx 11557 1 Longitudinal longitudinal JJ cord-010092-uftc8inx 11557 2 studies study NNS cord-010092-uftc8inx 11557 3 on on IN cord-010092-uftc8inx 11557 4 large large JJ cord-010092-uftc8inx 11557 5 sample sample NN cord-010092-uftc8inx 11557 6 size size NN cord-010092-uftc8inx 11557 7 are be VBP cord-010092-uftc8inx 11557 8 needed need VBN cord-010092-uftc8inx 11557 9 to to TO cord-010092-uftc8inx 11557 10 validate validate VB cord-010092-uftc8inx 11557 11 this this DT cord-010092-uftc8inx 11557 12 study study NN cord-010092-uftc8inx 11557 13 . . . cord-010092-uftc8inx 11558 1 uncertain uncertain JJ cord-010092-uftc8inx 11558 2 . . . cord-010092-uftc8inx 11559 1 An an DT cord-010092-uftc8inx 11559 2 ovine ovine JJ cord-010092-uftc8inx 11559 3 model model NN cord-010092-uftc8inx 11559 4 enables enable VBZ cord-010092-uftc8inx 11559 5 comparisons comparison NNS cord-010092-uftc8inx 11559 6 of of IN cord-010092-uftc8inx 11559 7 ; ; : cord-010092-uftc8inx 11559 8 ( ( -LRB- cord-010092-uftc8inx 11559 9 a a DT cord-010092-uftc8inx 11559 10 ) ) -RRB- cord-010092-uftc8inx 11559 11 invasive invasive JJ cord-010092-uftc8inx 11559 12 and and CC cord-010092-uftc8inx 11559 13 non non JJ cord-010092-uftc8inx 11559 14 - - JJ cord-010092-uftc8inx 11559 15 invasive invasive JJ cord-010092-uftc8inx 11559 16 methods method NNS cord-010092-uftc8inx 11559 17 to to TO cord-010092-uftc8inx 11559 18 measure measure VB cord-010092-uftc8inx 11559 19 oxygen oxygen NN cord-010092-uftc8inx 11559 20 delivery delivery NN cord-010092-uftc8inx 11559 21 and and CC cord-010092-uftc8inx 11559 22 utilisation utilisation NN cord-010092-uftc8inx 11559 23 at at IN cord-010092-uftc8inx 11559 24 a a DT cord-010092-uftc8inx 11559 25 tissue tissue NN cord-010092-uftc8inx 11559 26 level level NN cord-010092-uftc8inx 11559 27 , , , cord-010092-uftc8inx 11559 28 and and CC cord-010092-uftc8inx 11559 29 of of IN cord-010092-uftc8inx 11559 30 ( ( -LRB- cord-010092-uftc8inx 11559 31 b b NN cord-010092-uftc8inx 11559 32 ) ) -RRB- cord-010092-uftc8inx 11559 33 the the DT cord-010092-uftc8inx 11559 34 efficacy efficacy NN cord-010092-uftc8inx 11559 35 of of IN cord-010092-uftc8inx 11559 36 various various JJ cord-010092-uftc8inx 11559 37 resuscitation resuscitation NN cord-010092-uftc8inx 11559 38 fluids fluid NNS cord-010092-uftc8inx 11559 39 and and CC cord-010092-uftc8inx 11559 40 transfusion transfusion NN cord-010092-uftc8inx 11559 41 protocols protocol NNS cord-010092-uftc8inx 11559 42 in in IN cord-010092-uftc8inx 11559 43 treating treat VBG cord-010092-uftc8inx 11559 44 haemorrhagic haemorrhagic JJ cord-010092-uftc8inx 11559 45 shock shock NN cord-010092-uftc8inx 11559 46 . . . cord-010092-uftc8inx 11560 1 Aims aim VBZ cord-010092-uftc8inx 11560 2 : : : cord-010092-uftc8inx 11560 3 To to TO cord-010092-uftc8inx 11560 4 develop develop VB cord-010092-uftc8inx 11560 5 an an DT cord-010092-uftc8inx 11560 6 ovine ovine JJ cord-010092-uftc8inx 11560 7 model model NN cord-010092-uftc8inx 11560 8 of of IN cord-010092-uftc8inx 11560 9 haemorrhagic haemorrhagic JJ cord-010092-uftc8inx 11560 10 shock shock NN cord-010092-uftc8inx 11560 11 . . . cord-010092-uftc8inx 11561 1 Methods method NNS cord-010092-uftc8inx 11561 2 : : : cord-010092-uftc8inx 11561 3 Sheep Sheep NNP cord-010092-uftc8inx 11561 4 ( ( -LRB- cord-010092-uftc8inx 11561 5 n n NN cord-010092-uftc8inx 11561 6 = = SYM cord-010092-uftc8inx 11561 7 4 4 CD cord-010092-uftc8inx 11561 8 ) ) -RRB- cord-010092-uftc8inx 11561 9 were be VBD cord-010092-uftc8inx 11561 10 anaesthetised anaesthetise VBN cord-010092-uftc8inx 11561 11 , , , cord-010092-uftc8inx 11561 12 ventilated ventilate VBN cord-010092-uftc8inx 11561 13 and and CC cord-010092-uftc8inx 11561 14 instrumented instrument VBN cord-010092-uftc8inx 11561 15 . . . cord-010092-uftc8inx 11562 1 Instrumentation instrumentation NN cord-010092-uftc8inx 11562 2 included include VBD cord-010092-uftc8inx 11562 3 blood blood NN cord-010092-uftc8inx 11562 4 flow flow NN cord-010092-uftc8inx 11562 5 , , , cord-010092-uftc8inx 11562 6 perfusion perfusion NN cord-010092-uftc8inx 11562 7 , , , cord-010092-uftc8inx 11562 8 and and CC cord-010092-uftc8inx 11562 9 microdialysis microdialysis NN cord-010092-uftc8inx 11562 10 probes probe NNS cord-010092-uftc8inx 11562 11 placed place VBN cord-010092-uftc8inx 11562 12 in in IN cord-010092-uftc8inx 11562 13 the the DT cord-010092-uftc8inx 11562 14 brain brain NN cord-010092-uftc8inx 11562 15 , , , cord-010092-uftc8inx 11562 16 kidney kidney NN cord-010092-uftc8inx 11562 17 , , , cord-010092-uftc8inx 11562 18 liver liver NN cord-010092-uftc8inx 11562 19 and and CC cord-010092-uftc8inx 11562 20 skeletal skeletal JJ cord-010092-uftc8inx 11562 21 muscle muscle NN cord-010092-uftc8inx 11562 22 . . . cord-010092-uftc8inx 11563 1 Haemodynamic Haemodynamic NNP cord-010092-uftc8inx 11563 2 , , , cord-010092-uftc8inx 11563 3 tissue tissue NN cord-010092-uftc8inx 11563 4 oxygenation oxygenation NN cord-010092-uftc8inx 11563 5 , , , cord-010092-uftc8inx 11563 6 tissue tissue NN cord-010092-uftc8inx 11563 7 flow flow NN cord-010092-uftc8inx 11563 8 and and CC cord-010092-uftc8inx 11563 9 respiratory respiratory JJ cord-010092-uftc8inx 11563 10 data datum NNS cord-010092-uftc8inx 11563 11 were be VBD cord-010092-uftc8inx 11563 12 recorded record VBN cord-010092-uftc8inx 11563 13 continuously continuously RB cord-010092-uftc8inx 11563 14 by by IN cord-010092-uftc8inx 11563 15 data datum NNS cord-010092-uftc8inx 11563 16 capture capture NN cord-010092-uftc8inx 11563 17 software software NN cord-010092-uftc8inx 11563 18 . . . cord-010092-uftc8inx 11564 1 Non non JJ cord-010092-uftc8inx 11564 2 - - JJ cord-010092-uftc8inx 11564 3 invasive invasive JJ cord-010092-uftc8inx 11564 4 assessments assessment NNS cord-010092-uftc8inx 11564 5 , , , cord-010092-uftc8inx 11564 6 including include VBG cord-010092-uftc8inx 11564 7 brain brain NN cord-010092-uftc8inx 11564 8 and and CC cord-010092-uftc8inx 11564 9 muscle muscle NN cord-010092-uftc8inx 11564 10 oxygen oxygen NN cord-010092-uftc8inx 11564 11 saturation saturation NN cord-010092-uftc8inx 11564 12 by by IN cord-010092-uftc8inx 11564 13 NIRS NIRS NNP cord-010092-uftc8inx 11564 14 , , , cord-010092-uftc8inx 11564 15 and and CC cord-010092-uftc8inx 11564 16 visualisation visualisation NN cord-010092-uftc8inx 11564 17 of of IN cord-010092-uftc8inx 11564 18 sub sub JJ cord-010092-uftc8inx 11564 19 - - JJ cord-010092-uftc8inx 11564 20 lingual lingual JJ cord-010092-uftc8inx 11564 21 microvascular microvascular JJ cord-010092-uftc8inx 11564 22 perfusion perfusion NN cord-010092-uftc8inx 11564 23 , , , cord-010092-uftc8inx 11564 24 as as RB cord-010092-uftc8inx 11564 25 well well RB cord-010092-uftc8inx 11564 26 as as IN cord-010092-uftc8inx 11564 27 arterial arterial JJ cord-010092-uftc8inx 11564 28 blood blood NN cord-010092-uftc8inx 11564 29 gas gas NN cord-010092-uftc8inx 11564 30 measurements measurement NNS cord-010092-uftc8inx 11564 31 and and CC cord-010092-uftc8inx 11564 32 plasma plasma NN cord-010092-uftc8inx 11564 33 / / SYM cord-010092-uftc8inx 11564 34 serum serum NN cord-010092-uftc8inx 11564 35 / / SYM cord-010092-uftc8inx 11564 36 urine urine NN cord-010092-uftc8inx 11564 37 collections collection NNS cord-010092-uftc8inx 11564 38 were be VBD cord-010092-uftc8inx 11564 39 made make VBN cord-010092-uftc8inx 11564 40 at at IN cord-010092-uftc8inx 11564 41 specific specific JJ cord-010092-uftc8inx 11564 42 timepoints timepoint NNS cord-010092-uftc8inx 11564 43 . . . cord-010092-uftc8inx 11565 1 After after IN cord-010092-uftc8inx 11565 2 a a DT cord-010092-uftc8inx 11565 3 baseline baseline JJ cord-010092-uftc8inx 11565 4 period period NN cord-010092-uftc8inx 11565 5 ( ( -LRB- cord-010092-uftc8inx 11565 6 1 1 CD cord-010092-uftc8inx 11565 7 h h NN cord-010092-uftc8inx 11565 8 ) ) -RRB- cord-010092-uftc8inx 11565 9 sheep sheep NNS cord-010092-uftc8inx 11565 10 were be VBD cord-010092-uftc8inx 11565 11 bled~40 bled~40 JJ cord-010092-uftc8inx 11565 12 % % NN cord-010092-uftc8inx 11565 13 of of IN cord-010092-uftc8inx 11565 14 their -PRON- PRP$ cord-010092-uftc8inx 11565 15 estimated estimate VBN cord-010092-uftc8inx 11565 16 blood blood NN cord-010092-uftc8inx 11565 17 volume volume NN cord-010092-uftc8inx 11565 18 ( ( -LRB- cord-010092-uftc8inx 11565 19 estimated estimate VBN cord-010092-uftc8inx 11565 20 at at IN cord-010092-uftc8inx 11565 21 65 65 CD cord-010092-uftc8inx 11565 22 mL ml NN cord-010092-uftc8inx 11565 23 / / SYM cord-010092-uftc8inx 11565 24 kg kg NN cord-010092-uftc8inx 11565 25 ) ) -RRB- cord-010092-uftc8inx 11565 26 to to IN cord-010092-uftc8inx 11565 27 a a DT cord-010092-uftc8inx 11565 28 mean mean JJ cord-010092-uftc8inx 11565 29 arterial arterial JJ cord-010092-uftc8inx 11565 30 blood blood NN cord-010092-uftc8inx 11565 31 pressure pressure NN cord-010092-uftc8inx 11565 32 ( ( -LRB- cord-010092-uftc8inx 11565 33 MAP MAP NNP cord-010092-uftc8inx 11565 34 ) ) -RRB- cord-010092-uftc8inx 11565 35 of of IN cord-010092-uftc8inx 11566 1 30 30 CD cord-010092-uftc8inx 11566 2 - - SYM cord-010092-uftc8inx 11566 3 40 40 CD cord-010092-uftc8inx 11566 4 mmHg mmHg NNS cord-010092-uftc8inx 11566 5 . . . cord-010092-uftc8inx 11567 1 Sheep Sheep NNS cord-010092-uftc8inx 11567 2 were be VBD cord-010092-uftc8inx 11567 3 then then RB cord-010092-uftc8inx 11567 4 resuscitated resuscitate VBN cord-010092-uftc8inx 11567 5 with with IN cord-010092-uftc8inx 11567 6 either either CC cord-010092-uftc8inx 11567 7 PlasmaLyte PlasmaLyte NNP cord-010092-uftc8inx 11567 8 â â . cord-010092-uftc8inx 11567 9 ( ( -LRB- cord-010092-uftc8inx 11568 1 up up IN cord-010092-uftc8inx 11568 2 to to TO cord-010092-uftc8inx 11568 3 20 20 CD cord-010092-uftc8inx 11568 4 mL ml NN cord-010092-uftc8inx 11568 5 / / SYM cord-010092-uftc8inx 11568 6 kg/ kg/ NNS cord-010092-uftc8inx 11568 7 hr hr NN cord-010092-uftc8inx 11568 8 ; ; : cord-010092-uftc8inx 11568 9 n n NN cord-010092-uftc8inx 11568 10 = = SYM cord-010092-uftc8inx 11568 11 3 3 CD cord-010092-uftc8inx 11568 12 ) ) -RRB- cord-010092-uftc8inx 11568 13 or or CC cord-010092-uftc8inx 11568 14 transfused transfuse VBN cord-010092-uftc8inx 11568 15 with with IN cord-010092-uftc8inx 11568 16 sheep sheep NN cord-010092-uftc8inx 11568 17 red red JJ cord-010092-uftc8inx 11568 18 cells cell NNS cord-010092-uftc8inx 11568 19 ( ( -LRB- cord-010092-uftc8inx 11568 20 n n NN cord-010092-uftc8inx 11568 21 = = SYM cord-010092-uftc8inx 11568 22 1 1 CD cord-010092-uftc8inx 11568 23 ) ) -RRB- cord-010092-uftc8inx 11568 24 to to TO cord-010092-uftc8inx 11568 25 achieve achieve VB cord-010092-uftc8inx 11568 26 a a DT cord-010092-uftc8inx 11568 27 MAP map NN cord-010092-uftc8inx 11569 1 > > XX cord-010092-uftc8inx 11570 1 65 65 CD cord-010092-uftc8inx 11570 2 mmHg mmHg NNS cord-010092-uftc8inx 11570 3 . . . cord-010092-uftc8inx 11570 4 Sheep Sheep NNS cord-010092-uftc8inx 11570 5 were be VBD cord-010092-uftc8inx 11570 6 euthanised euthanise VBN cord-010092-uftc8inx 11570 7 4 4 CD cord-010092-uftc8inx 11570 8 h h NN cord-010092-uftc8inx 11570 9 after after IN cord-010092-uftc8inx 11570 10 resuscitation resuscitation NN cord-010092-uftc8inx 11570 11 . . . cord-010092-uftc8inx 11571 1 Data datum NNS cord-010092-uftc8inx 11571 2 are be VBP cord-010092-uftc8inx 11571 3 presented present VBN cord-010092-uftc8inx 11571 4 as as IN cord-010092-uftc8inx 11571 5 mean mean JJ cord-010092-uftc8inx 11571 6 AE AE NNP cord-010092-uftc8inx 11571 7 standard standard JJ cord-010092-uftc8inx 11571 8 deviation deviation NN cord-010092-uftc8inx 11571 9 . . . cord-010092-uftc8inx 11572 1 Results result NNS cord-010092-uftc8inx 11572 2 : : : cord-010092-uftc8inx 11573 1 Sheep Sheep NNS cord-010092-uftc8inx 11573 2 were be VBD cord-010092-uftc8inx 11573 3 haemorrhaged haemorrhage VBN cord-010092-uftc8inx 11573 4 an an DT cord-010092-uftc8inx 11573 5 average average NN cord-010092-uftc8inx 11573 6 of of IN cord-010092-uftc8inx 11573 7 931.7 931.7 CD cord-010092-uftc8inx 11573 8 AE ae NN cord-010092-uftc8inx 11573 9 135.3 135.3 CD cord-010092-uftc8inx 11573 10 mL ml NN cord-010092-uftc8inx 11573 11 blood blood NN cord-010092-uftc8inx 11573 12 which which WDT cord-010092-uftc8inx 11573 13 combined combine VBN cord-010092-uftc8inx 11573 14 with with IN cord-010092-uftc8inx 11573 15 iatrogenic iatrogenic JJ cord-010092-uftc8inx 11573 16 blood blood NN cord-010092-uftc8inx 11573 17 loss loss NN cord-010092-uftc8inx 11573 18 ( ( -LRB- cord-010092-uftc8inx 11573 19 ~300 ~300 NNP cord-010092-uftc8inx 11573 20 mL ml NN cord-010092-uftc8inx 11573 21 ) ) -RRB- cord-010092-uftc8inx 11573 22 corresponded correspond VBD cord-010092-uftc8inx 11573 23 to to IN cord-010092-uftc8inx 11573 24 an an DT cord-010092-uftc8inx 11573 25 average average JJ cord-010092-uftc8inx 11573 26 40.2 40.2 CD cord-010092-uftc8inx 11573 27 AE AE NNP cord-010092-uftc8inx 11573 28 2.4 2.4 CD cord-010092-uftc8inx 11573 29 % % NN cord-010092-uftc8inx 11573 30 blood blood NN cord-010092-uftc8inx 11573 31 loss loss NN cord-010092-uftc8inx 11573 32 . . . cord-010092-uftc8inx 11574 1 Two two CD cord-010092-uftc8inx 11574 2 out out IN cord-010092-uftc8inx 11574 3 of of IN cord-010092-uftc8inx 11574 4 the the DT cord-010092-uftc8inx 11574 5 four four CD cord-010092-uftc8inx 11574 6 sheep sheep NNS cord-010092-uftc8inx 11574 7 met meet VBD cord-010092-uftc8inx 11574 8 clinical clinical JJ cord-010092-uftc8inx 11574 9 criteria criterion NNS cord-010092-uftc8inx 11574 10 for for IN cord-010092-uftc8inx 11574 11 haemorrhagic haemorrhagic JJ cord-010092-uftc8inx 11574 12 shock shock NN cord-010092-uftc8inx 11574 13 ( ( -LRB- cord-010092-uftc8inx 11574 14 MAP map NN cord-010092-uftc8inx 11574 15 = = SYM cord-010092-uftc8inx 11574 16 30 30 CD cord-010092-uftc8inx 11574 17 - - SYM cord-010092-uftc8inx 11574 18 40 40 CD cord-010092-uftc8inx 11574 19 mmHg mmHg NNS cord-010092-uftc8inx 11574 20 , , , cord-010092-uftc8inx 11574 21 lactate lactate NN cord-010092-uftc8inx 11574 22 > > XX cord-010092-uftc8inx 11575 1 4 4 LS cord-010092-uftc8inx 11575 2 mM mm CD cord-010092-uftc8inx 11575 3 , , , cord-010092-uftc8inx 11575 4 SvO SvO NNP cord-010092-uftc8inx 11575 5 2 2 CD cord-010092-uftc8inx 11575 6 < < XX cord-010092-uftc8inx 11575 7 60 60 CD cord-010092-uftc8inx 11575 8 % % NN cord-010092-uftc8inx 11575 9 ) ) -RRB- cord-010092-uftc8inx 11575 10 . . . cord-010092-uftc8inx 11576 1 Across across IN cord-010092-uftc8inx 11576 2 all all DT cord-010092-uftc8inx 11576 3 four four CD cord-010092-uftc8inx 11576 4 sheep sheep NNS cord-010092-uftc8inx 11576 5 the the DT cord-010092-uftc8inx 11576 6 nadir nadir NNP cord-010092-uftc8inx 11576 7 MAP MAP NNP cord-010092-uftc8inx 11576 8 averaged average VBD cord-010092-uftc8inx 11576 9 40.5 40.5 CD cord-010092-uftc8inx 11576 10 AE AE NNP cord-010092-uftc8inx 11576 11 13.1 13.1 CD cord-010092-uftc8inx 11576 12 mmHg mmHg NNS cord-010092-uftc8inx 11576 13 , , , cord-010092-uftc8inx 11576 14 lactate lactate NN cord-010092-uftc8inx 11576 15 peaked peak VBD cord-010092-uftc8inx 11576 16 at at IN cord-010092-uftc8inx 11576 17 3.9 3.9 CD cord-010092-uftc8inx 11576 18 AE AE NNP cord-010092-uftc8inx 11576 19 1 1 CD cord-010092-uftc8inx 11576 20 mmol/ mmol/ NN cord-010092-uftc8inx 11576 21 L l NN cord-010092-uftc8inx 11576 22 , , , cord-010092-uftc8inx 11576 23 and and CC cord-010092-uftc8inx 11576 24 nadir nadir NNP cord-010092-uftc8inx 11576 25 SvO SvO NNP cord-010092-uftc8inx 11576 26 2 2 CD cord-010092-uftc8inx 11576 27 was be VBD cord-010092-uftc8inx 11576 28 41.3 41.3 CD cord-010092-uftc8inx 11576 29 AE AE NNP cord-010092-uftc8inx 11576 30 17.9 17.9 CD cord-010092-uftc8inx 11576 31 % % NN cord-010092-uftc8inx 11576 32 . . . cord-010092-uftc8inx 11577 1 All all DT cord-010092-uftc8inx 11577 2 sheep sheep NNS cord-010092-uftc8inx 11577 3 survived survive VBD cord-010092-uftc8inx 11577 4 to to IN cord-010092-uftc8inx 11577 5 the the DT cord-010092-uftc8inx 11577 6 end end NN cord-010092-uftc8inx 11577 7 of of IN cord-010092-uftc8inx 11577 8 the the DT cord-010092-uftc8inx 11577 9 experimental experimental JJ cord-010092-uftc8inx 11577 10 protocol protocol NN cord-010092-uftc8inx 11577 11 . . . cord-010092-uftc8inx 11578 1 Summary Summary NNP cord-010092-uftc8inx 11578 2 / / SYM cord-010092-uftc8inx 11578 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 11578 4 : : : cord-010092-uftc8inx 11579 1 These these DT cord-010092-uftc8inx 11579 2 data datum NNS cord-010092-uftc8inx 11579 3 demonstrate demonstrate VBP cord-010092-uftc8inx 11579 4 the the DT cord-010092-uftc8inx 11579 5 successful successful JJ cord-010092-uftc8inx 11579 6 induction induction NN cord-010092-uftc8inx 11579 7 of of IN cord-010092-uftc8inx 11579 8 haemorrhagic haemorrhagic JJ cord-010092-uftc8inx 11579 9 shock shock NN cord-010092-uftc8inx 11579 10 in in IN cord-010092-uftc8inx 11579 11 an an DT cord-010092-uftc8inx 11579 12 ovine ovine JJ cord-010092-uftc8inx 11579 13 model model NN cord-010092-uftc8inx 11579 14 . . . cord-010092-uftc8inx 11580 1 Further further JJ cord-010092-uftc8inx 11580 2 experiments experiment NNS cord-010092-uftc8inx 11580 3 are be VBP cord-010092-uftc8inx 11580 4 planned plan VBN cord-010092-uftc8inx 11580 5 to to TO cord-010092-uftc8inx 11580 6 improve improve VB cord-010092-uftc8inx 11580 7 the the DT cord-010092-uftc8inx 11580 8 protocol protocol NN cord-010092-uftc8inx 11580 9 and and CC cord-010092-uftc8inx 11580 10 to to TO cord-010092-uftc8inx 11580 11 achieve achieve VB cord-010092-uftc8inx 11580 12 100 100 CD cord-010092-uftc8inx 11580 13 % % NN cord-010092-uftc8inx 11580 14 incidence incidence NN cord-010092-uftc8inx 11580 15 of of IN cord-010092-uftc8inx 11580 16 haemorrhagic haemorrhagic JJ cord-010092-uftc8inx 11580 17 shock shock NN cord-010092-uftc8inx 11580 18 , , , cord-010092-uftc8inx 11580 19 and and CC cord-010092-uftc8inx 11580 20 then then RB cord-010092-uftc8inx 11580 21 to to TO cord-010092-uftc8inx 11580 22 compare compare VB cord-010092-uftc8inx 11580 23 invasive invasive JJ cord-010092-uftc8inx 11580 24 and and CC cord-010092-uftc8inx 11580 25 non non JJ cord-010092-uftc8inx 11580 26 - - JJ cord-010092-uftc8inx 11580 27 invasive invasive JJ cord-010092-uftc8inx 11580 28 measures measure NNS cord-010092-uftc8inx 11580 29 of of IN cord-010092-uftc8inx 11580 30 oxygen oxygen NN cord-010092-uftc8inx 11580 31 delivery delivery NN cord-010092-uftc8inx 11580 32 and and CC cord-010092-uftc8inx 11580 33 utilisation utilisation NN cord-010092-uftc8inx 11580 34 as as RB cord-010092-uftc8inx 11580 35 well well RB cord-010092-uftc8inx 11580 36 as as IN cord-010092-uftc8inx 11580 37 the the DT cord-010092-uftc8inx 11580 38 efficacy efficacy NN cord-010092-uftc8inx 11580 39 of of IN cord-010092-uftc8inx 11580 40 different different JJ cord-010092-uftc8inx 11580 41 resuscitation resuscitation NN cord-010092-uftc8inx 11580 42 fluids fluid NNS cord-010092-uftc8inx 11580 43 and and CC cord-010092-uftc8inx 11580 44 red red JJ cord-010092-uftc8inx 11580 45 cell cell NN cord-010092-uftc8inx 11580 46 transfusion transfusion NN cord-010092-uftc8inx 11580 47 . . . cord-010092-uftc8inx 11581 1 Adverse adverse JJ cord-010092-uftc8inx 11581 2 events event NNS cord-010092-uftc8inx 11581 3 , , , cord-010092-uftc8inx 11581 4 including include VBG cord-010092-uftc8inx 11581 5 TRALI TRALI NNP cord-010092-uftc8inx 11581 6 P-515 P-515 NNS cord-010092-uftc8inx 11581 7 Bilirubin bilirubin NN cord-010092-uftc8inx 11581 8 were be VBD cord-010092-uftc8inx 11581 9 recorded record VBN cord-010092-uftc8inx 11581 10 within within IN cord-010092-uftc8inx 11581 11 the the DT cord-010092-uftc8inx 11581 12 28-day 28-day CD cord-010092-uftc8inx 11581 13 period period NN cord-010092-uftc8inx 11581 14 . . . cord-010092-uftc8inx 11582 1 The the DT cord-010092-uftc8inx 11582 2 clinical clinical JJ cord-010092-uftc8inx 11582 3 parameters parameter NNS cord-010092-uftc8inx 11582 4 were be VBD cord-010092-uftc8inx 11582 5 compared compare VBN cord-010092-uftc8inx 11582 6 against against IN cord-010092-uftc8inx 11582 7 the the DT cord-010092-uftc8inx 11582 8 reaction reaction NN cord-010092-uftc8inx 11582 9 strength strength NN cord-010092-uftc8inx 11582 10 of of IN cord-010092-uftc8inx 11582 11 the the DT cord-010092-uftc8inx 11582 12 antibody antibody NN cord-010092-uftc8inx 11582 13 reactions reaction NNS cord-010092-uftc8inx 11582 14 . . . cord-010092-uftc8inx 11583 1 The the DT cord-010092-uftc8inx 11583 2 automated automate VBN cord-010092-uftc8inx 11583 3 strength strength NN cord-010092-uftc8inx 11583 4 was be VBD cord-010092-uftc8inx 11583 5 measured measure VBN cord-010092-uftc8inx 11583 6 by by IN cord-010092-uftc8inx 11583 7 Solid solid JJ cord-010092-uftc8inx 11583 8 phase phase NN cord-010092-uftc8inx 11583 9 . . . cord-010092-uftc8inx 11584 1 The the DT cord-010092-uftc8inx 11584 2 manual manual JJ cord-010092-uftc8inx 11584 3 testing testing NN cord-010092-uftc8inx 11584 4 consisted consist VBD cord-010092-uftc8inx 11584 5 of of IN cord-010092-uftc8inx 11584 6 a a DT cord-010092-uftc8inx 11584 7 15-min 15-min CD cord-010092-uftc8inx 11584 8 incubation incubation NN cord-010092-uftc8inx 11584 9 using use VBG cord-010092-uftc8inx 11584 10 LISS LISS NNP cord-010092-uftc8inx 11584 11 and and CC cord-010092-uftc8inx 11584 12 adding add VBG cord-010092-uftc8inx 11584 13 Monospecific Monospecific NNP cord-010092-uftc8inx 11585 1 IgG. IgG. NNP cord-010092-uftc8inx 11586 1 The the DT cord-010092-uftc8inx 11586 2 DAT DAT NNP cord-010092-uftc8inx 11586 3 was be VBD cord-010092-uftc8inx 11586 4 performed perform VBN cord-010092-uftc8inx 11586 5 manually manually RB cord-010092-uftc8inx 11586 6 by by IN cord-010092-uftc8inx 11586 7 adding add VBG cord-010092-uftc8inx 11586 8 Poly Poly NNP cord-010092-uftc8inx 11586 9 - - HYPH cord-010092-uftc8inx 11586 10 specific specific JJ cord-010092-uftc8inx 11586 11 IgG igg NN cord-010092-uftc8inx 11586 12 and and CC cord-010092-uftc8inx 11586 13 then then RB cord-010092-uftc8inx 11586 14 testing test VBG cord-010092-uftc8inx 11586 15 with with IN cord-010092-uftc8inx 11586 16 Monospecific Monospecific NNP cord-010092-uftc8inx 11586 17 IgG igg NN cord-010092-uftc8inx 11586 18 and and CC cord-010092-uftc8inx 11586 19 C3d C3d NNP cord-010092-uftc8inx 11586 20 . . . cord-010092-uftc8inx 11587 1 The the DT cord-010092-uftc8inx 11587 2 Rh Rh NNP cord-010092-uftc8inx 11587 3 Group Group NNP cord-010092-uftc8inx 11587 4 and and CC cord-010092-uftc8inx 11587 5 non non NNP cord-010092-uftc8inx 11587 6 - - JJ cord-010092-uftc8inx 11587 7 Rh Rh NNP cord-010092-uftc8inx 11587 8 group group NN cord-010092-uftc8inx 11587 9 had have VBD cord-010092-uftc8inx 11587 10 11 11 CD cord-010092-uftc8inx 11587 11 and and CC cord-010092-uftc8inx 11587 12 10 10 CD cord-010092-uftc8inx 11587 13 cases case NNS cord-010092-uftc8inx 11587 14 performed perform VBN cord-010092-uftc8inx 11587 15 manually manually RB cord-010092-uftc8inx 11587 16 , , , cord-010092-uftc8inx 11587 17 and and CC cord-010092-uftc8inx 11587 18 results result NNS cord-010092-uftc8inx 11587 19 were be VBD cord-010092-uftc8inx 11587 20 2 2 CD cord-010092-uftc8inx 11587 21 + + SYM cord-010092-uftc8inx 11587 22 or or CC cord-010092-uftc8inx 11587 23 weaker weak JJR cord-010092-uftc8inx 11587 24 further further RB cord-010092-uftc8inx 11587 25 indicating indicate VBG cord-010092-uftc8inx 11587 26 the the DT cord-010092-uftc8inx 11587 27 manual manual JJ cord-010092-uftc8inx 11587 28 strength strength NN cord-010092-uftc8inx 11587 29 did do VBD cord-010092-uftc8inx 11587 30 not not RB cord-010092-uftc8inx 11587 31 correlate correlate VB cord-010092-uftc8inx 11587 32 with with IN cord-010092-uftc8inx 11587 33 the the DT cord-010092-uftc8inx 11587 34 clinical clinical JJ cord-010092-uftc8inx 11587 35 hemolysis hemolysis NN cord-010092-uftc8inx 11587 36 . . . cord-010092-uftc8inx 11588 1 Likewise likewise RB cord-010092-uftc8inx 11588 2 , , , cord-010092-uftc8inx 11588 3 in in IN cord-010092-uftc8inx 11588 4 31/44 31/44 CD cord-010092-uftc8inx 11588 5 ( ( -LRB- cord-010092-uftc8inx 11588 6 70 70 CD cord-010092-uftc8inx 11588 7 % % NN cord-010092-uftc8inx 11588 8 ) ) -RRB- cord-010092-uftc8inx 11588 9 the the DT cord-010092-uftc8inx 11588 10 DAT DAT NNP cord-010092-uftc8inx 11588 11 was be VBD cord-010092-uftc8inx 11588 12 negative negative JJ cord-010092-uftc8inx 11588 13 , , , cord-010092-uftc8inx 11588 14 and and CC cord-010092-uftc8inx 11588 15 did do VBD cord-010092-uftc8inx 11588 16 not not RB cord-010092-uftc8inx 11588 17 show show VB cord-010092-uftc8inx 11588 18 any any DT cord-010092-uftc8inx 11588 19 correlation correlation NN cord-010092-uftc8inx 11588 20 with with IN cord-010092-uftc8inx 11588 21 clinical clinical JJ cord-010092-uftc8inx 11588 22 hemolysis hemolysis NN cord-010092-uftc8inx 11588 23 . . . cord-010092-uftc8inx 11589 1 However however RB cord-010092-uftc8inx 11589 2 , , , cord-010092-uftc8inx 11589 3 when when WRB cord-010092-uftc8inx 11589 4 LDH LDH NNP cord-010092-uftc8inx 11589 5 and and CC cord-010092-uftc8inx 11589 6 Bilirubin Bilirubin NNP cord-010092-uftc8inx 11589 7 were be VBD cord-010092-uftc8inx 11589 8 measured measure VBN cord-010092-uftc8inx 11589 9 , , , cord-010092-uftc8inx 11589 10 the the DT cord-010092-uftc8inx 11589 11 two two CD cord-010092-uftc8inx 11589 12 parameters parameter NNS cord-010092-uftc8inx 11589 13 increased increase VBD cord-010092-uftc8inx 11589 14 as as IN cord-010092-uftc8inx 11589 15 the the DT cord-010092-uftc8inx 11589 16 automated automate VBN cord-010092-uftc8inx 11589 17 strength strength NN cord-010092-uftc8inx 11589 18 of of IN cord-010092-uftc8inx 11589 19 the the DT cord-010092-uftc8inx 11589 20 antibodies antibody NNS cord-010092-uftc8inx 11589 21 increased increase VBD cord-010092-uftc8inx 11589 22 . . . cord-010092-uftc8inx 11590 1 Summary Summary NNP cord-010092-uftc8inx 11590 2 / / SYM cord-010092-uftc8inx 11590 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 11590 4 : : : cord-010092-uftc8inx 11591 1 Most Most JJS cord-010092-uftc8inx 11591 2 of of IN cord-010092-uftc8inx 11591 3 the the DT cord-010092-uftc8inx 11591 4 DSHTR DSHTR NNP cord-010092-uftc8inx 11591 5 investigation investigation NN cord-010092-uftc8inx 11591 6 was be VBD cord-010092-uftc8inx 11591 7 not not RB cord-010092-uftc8inx 11591 8 associated associate VBN cord-010092-uftc8inx 11591 9 with with IN cord-010092-uftc8inx 11591 10 overt overt JJ cord-010092-uftc8inx 11591 11 accelerated accelerate VBN cord-010092-uftc8inx 11591 12 red red JJ cord-010092-uftc8inx 11591 13 cell cell NN cord-010092-uftc8inx 11591 14 destruction destruction NN cord-010092-uftc8inx 11591 15 . . . cord-010092-uftc8inx 11592 1 A a DT cord-010092-uftc8inx 11592 2 strong strong JJ cord-010092-uftc8inx 11592 3 correlation correlation NN cord-010092-uftc8inx 11592 4 was be VBD cord-010092-uftc8inx 11592 5 observed observe VBN cord-010092-uftc8inx 11592 6 only only RB cord-010092-uftc8inx 11592 7 between between IN cord-010092-uftc8inx 11592 8 the the DT cord-010092-uftc8inx 11592 9 automated automate VBN cord-010092-uftc8inx 11592 10 immunohematology immunohematology NN cord-010092-uftc8inx 11592 11 testing testing NN cord-010092-uftc8inx 11592 12 results result NNS cord-010092-uftc8inx 11592 13 and and CC cord-010092-uftc8inx 11592 14 other other JJ cord-010092-uftc8inx 11592 15 laboratory laboratory NN cord-010092-uftc8inx 11592 16 markers marker NNS cord-010092-uftc8inx 11592 17 of of IN cord-010092-uftc8inx 11592 18 hemolysis hemolysis NN cord-010092-uftc8inx 11592 19 . . . cord-010092-uftc8inx 11593 1 In in IN cord-010092-uftc8inx 11593 2 our -PRON- PRP$ cord-010092-uftc8inx 11593 3 experience experience NN cord-010092-uftc8inx 11593 4 , , , cord-010092-uftc8inx 11593 5 the the DT cord-010092-uftc8inx 11593 6 direct direct JJ cord-010092-uftc8inx 11593 7 antiglobulin antiglobulin NN cord-010092-uftc8inx 11593 8 test test NN cord-010092-uftc8inx 11593 9 and and CC cord-010092-uftc8inx 11593 10 manual manual JJ cord-010092-uftc8inx 11593 11 strength strength NN cord-010092-uftc8inx 11593 12 showed show VBD cord-010092-uftc8inx 11593 13 no no DT cord-010092-uftc8inx 11593 14 correlation correlation NN cord-010092-uftc8inx 11593 15 . . . cord-010092-uftc8inx 11594 1 Background background NN cord-010092-uftc8inx 11594 2 : : : cord-010092-uftc8inx 11595 1 Numerous numerous JJ cord-010092-uftc8inx 11595 2 transfused transfuse VBN cord-010092-uftc8inx 11595 3 patients patient NNS cord-010092-uftc8inx 11595 4 present present JJ cord-010092-uftc8inx 11595 5 severe severe JJ cord-010092-uftc8inx 11595 6 , , , cord-010092-uftc8inx 11595 7 sometimes sometimes RB cord-010092-uftc8inx 11595 8 critical critical JJ cord-010092-uftc8inx 11595 9 clinical clinical JJ cord-010092-uftc8inx 11595 10 conditions condition NNS cord-010092-uftc8inx 11595 11 . . . cord-010092-uftc8inx 11596 1 The the DT cord-010092-uftc8inx 11596 2 occurrence occurrence NN cord-010092-uftc8inx 11596 3 of of IN cord-010092-uftc8inx 11596 4 adverse adverse JJ cord-010092-uftc8inx 11596 5 transfusion transfusion NN cord-010092-uftc8inx 11596 6 reactions reaction NNS cord-010092-uftc8inx 11596 7 ( ( -LRB- cord-010092-uftc8inx 11596 8 ATR ATR NNP cord-010092-uftc8inx 11596 9 ) ) -RRB- cord-010092-uftc8inx 11596 10 may may MD cord-010092-uftc8inx 11596 11 induce induce VB cord-010092-uftc8inx 11596 12 deterioration deterioration NN cord-010092-uftc8inx 11596 13 in in IN cord-010092-uftc8inx 11596 14 the the DT cord-010092-uftc8inx 11596 15 clinical clinical JJ cord-010092-uftc8inx 11596 16 condition condition NN cord-010092-uftc8inx 11596 17 with with IN cord-010092-uftc8inx 11596 18 a a DT cord-010092-uftc8inx 11596 19 worsened worsen VBN cord-010092-uftc8inx 11596 20 clinical clinical JJ cord-010092-uftc8inx 11596 21 course course NN cord-010092-uftc8inx 11596 22 and and CC cord-010092-uftc8inx 11596 23 a a DT cord-010092-uftc8inx 11596 24 lifethreatening lifethreatening JJ cord-010092-uftc8inx 11596 25 or or CC cord-010092-uftc8inx 11596 26 fatal fatal JJ cord-010092-uftc8inx 11596 27 outcome outcome NN cord-010092-uftc8inx 11596 28 as as IN cord-010092-uftc8inx 11596 29 is be VBZ cord-010092-uftc8inx 11596 30 the the DT cord-010092-uftc8inx 11596 31 case case NN cord-010092-uftc8inx 11596 32 with with IN cord-010092-uftc8inx 11596 33 nervous nervous JJ cord-010092-uftc8inx 11596 34 system system NN cord-010092-uftc8inx 11596 35 impairment impairment NN cord-010092-uftc8inx 11596 36 . . . cord-010092-uftc8inx 11597 1 In in IN cord-010092-uftc8inx 11597 2 France France NNP cord-010092-uftc8inx 11597 3 , , , cord-010092-uftc8inx 11597 4 in in IN cord-010092-uftc8inx 11597 5 2017 2017 CD cord-010092-uftc8inx 11597 6 , , , cord-010092-uftc8inx 11597 7 out out IN cord-010092-uftc8inx 11597 8 of of IN cord-010092-uftc8inx 11597 9 7,276 7,276 CD cord-010092-uftc8inx 11597 10 notified notify VBN cord-010092-uftc8inx 11597 11 ATRs atr NNS cord-010092-uftc8inx 11597 12 , , , cord-010092-uftc8inx 11597 13 113 113 CD cord-010092-uftc8inx 11597 14 ( ( -LRB- cord-010092-uftc8inx 11597 15 1.5 1.5 CD cord-010092-uftc8inx 11597 16 % % NN cord-010092-uftc8inx 11597 17 ) ) -RRB- cord-010092-uftc8inx 11597 18 and and CC cord-010092-uftc8inx 11597 19 6 6 CD cord-010092-uftc8inx 11597 20 ( ( -LRB- cord-010092-uftc8inx 11597 21 0.1 0.1 CD cord-010092-uftc8inx 11597 22 % % NN cord-010092-uftc8inx 11597 23 ) ) -RRB- cord-010092-uftc8inx 11597 24 were be VBD cord-010092-uftc8inx 11597 25 life life NN cord-010092-uftc8inx 11597 26 - - HYPH cord-010092-uftc8inx 11597 27 threatening threaten VBG cord-010092-uftc8inx 11597 28 and and CC cord-010092-uftc8inx 11597 29 death death NN cord-010092-uftc8inx 11597 30 respectively respectively RB cord-010092-uftc8inx 11597 31 . . . cord-010092-uftc8inx 11598 1 Aims aim VBZ cord-010092-uftc8inx 11598 2 : : : cord-010092-uftc8inx 11599 1 Our -PRON- PRP$ cord-010092-uftc8inx 11599 2 aim aim NN cord-010092-uftc8inx 11599 3 was be VBD cord-010092-uftc8inx 11599 4 to to TO cord-010092-uftc8inx 11599 5 evaluate evaluate VB cord-010092-uftc8inx 11599 6 the the DT cord-010092-uftc8inx 11599 7 notified notify VBN cord-010092-uftc8inx 11599 8 ATRs atr NNS cord-010092-uftc8inx 11599 9 with with IN cord-010092-uftc8inx 11599 10 neurological neurological JJ cord-010092-uftc8inx 11599 11 signs sign NNS cord-010092-uftc8inx 11599 12 that that WDT cord-010092-uftc8inx 11599 13 occurred occur VBD cord-010092-uftc8inx 11599 14 in in IN cord-010092-uftc8inx 11599 15 transfused transfuse VBN cord-010092-uftc8inx 11599 16 patients patient NNS cord-010092-uftc8inx 11599 17 over over IN cord-010092-uftc8inx 11599 18 a a DT cord-010092-uftc8inx 11599 19 period period NN cord-010092-uftc8inx 11599 20 of of IN cord-010092-uftc8inx 11599 21 six six CD cord-010092-uftc8inx 11599 22 years year NNS cord-010092-uftc8inx 11599 23 and and CC cord-010092-uftc8inx 11599 24 six six CD cord-010092-uftc8inx 11599 25 months month NNS cord-010092-uftc8inx 11599 26 in in IN cord-010092-uftc8inx 11599 27 hospitals hospital NNS cord-010092-uftc8inx 11599 28 in in IN cord-010092-uftc8inx 11599 29 the the DT cord-010092-uftc8inx 11599 30 Auvergne Auvergne NNP cord-010092-uftc8inx 11599 31 Rhône Rhône NNP cord-010092-uftc8inx 11599 32 Alpes Alpes NNP cord-010092-uftc8inx 11599 33 area area NN cord-010092-uftc8inx 11599 34 . . . cord-010092-uftc8inx 11600 1 The the DT cord-010092-uftc8inx 11600 2 study study NN cord-010092-uftc8inx 11600 3 included include VBD cord-010092-uftc8inx 11600 4 patients patient NNS cord-010092-uftc8inx 11600 5 with with IN cord-010092-uftc8inx 11600 6 reported report VBN cord-010092-uftc8inx 11600 7 ATRs atr NNS cord-010092-uftc8inx 11600 8 in in IN cord-010092-uftc8inx 11600 9 hospitals hospital NNS cord-010092-uftc8inx 11600 10 in in IN cord-010092-uftc8inx 11600 11 this this DT cord-010092-uftc8inx 11600 12 area area NN cord-010092-uftc8inx 11600 13 from from IN cord-010092-uftc8inx 11600 14 January January NNP cord-010092-uftc8inx 11600 15 1 1 CD cord-010092-uftc8inx 11600 16 st st NNP cord-010092-uftc8inx 11600 17 2010 2010 CD cord-010092-uftc8inx 11600 18 to to IN cord-010092-uftc8inx 11600 19 June June NNP cord-010092-uftc8inx 11600 20 30 30 CD cord-010092-uftc8inx 11600 21 th th CD cord-010092-uftc8inx 11600 22 2018 2018 CD cord-010092-uftc8inx 11600 23 . . . cord-010092-uftc8inx 11601 1 Each each DT cord-010092-uftc8inx 11601 2 ATR ATR NNP cord-010092-uftc8inx 11601 3 was be VBD cord-010092-uftc8inx 11601 4 registered register VBN cord-010092-uftc8inx 11601 5 in in IN cord-010092-uftc8inx 11601 6 the the DT cord-010092-uftc8inx 11601 7 national national JJ cord-010092-uftc8inx 11601 8 haemovigilance haemovigilance NNP cord-010092-uftc8inx 11601 9 database database NN cord-010092-uftc8inx 11601 10 system system NN cord-010092-uftc8inx 11601 11 . . . cord-010092-uftc8inx 11602 1 Two two CD cord-010092-uftc8inx 11602 2 signs sign NNS cord-010092-uftc8inx 11602 3 observed observe VBD cord-010092-uftc8inx 11602 4 at at IN cord-010092-uftc8inx 11602 5 the the DT cord-010092-uftc8inx 11602 6 time time NN cord-010092-uftc8inx 11602 7 of of IN cord-010092-uftc8inx 11602 8 the the DT cord-010092-uftc8inx 11602 9 ATR ATR NNP cord-010092-uftc8inx 11602 10 were be VBD cord-010092-uftc8inx 11602 11 analyzed analyze VBN cord-010092-uftc8inx 11602 12 : : : cord-010092-uftc8inx 11602 13 unconsciousness unconsciousness NN cord-010092-uftc8inx 11602 14 and and CC cord-010092-uftc8inx 11602 15 convulsions convulsion NNS cord-010092-uftc8inx 11602 16 . . . cord-010092-uftc8inx 11603 1 Stroke stroke NN cord-010092-uftc8inx 11603 2 was be VBD cord-010092-uftc8inx 11603 3 excluded exclude VBN cord-010092-uftc8inx 11603 4 . . . cord-010092-uftc8inx 11604 1 The the DT cord-010092-uftc8inx 11604 2 type type NN cord-010092-uftc8inx 11604 3 of of IN cord-010092-uftc8inx 11604 4 ATR ATR NNP cord-010092-uftc8inx 11604 5 , , , cord-010092-uftc8inx 11604 6 its -PRON- PRP$ cord-010092-uftc8inx 11604 7 severity severity NN cord-010092-uftc8inx 11604 8 , , , cord-010092-uftc8inx 11604 9 the the DT cord-010092-uftc8inx 11604 10 blood blood NN cord-010092-uftc8inx 11604 11 product product NN cord-010092-uftc8inx 11604 12 involved involve VBN cord-010092-uftc8inx 11604 13 and and CC cord-010092-uftc8inx 11604 14 its -PRON- PRP$ cord-010092-uftc8inx 11604 15 imputability imputability NN cord-010092-uftc8inx 11604 16 were be VBD cord-010092-uftc8inx 11604 17 studied study VBN cord-010092-uftc8inx 11604 18 . . . cord-010092-uftc8inx 11605 1 Results result NNS cord-010092-uftc8inx 11605 2 : : : cord-010092-uftc8inx 11606 1 During during IN cord-010092-uftc8inx 11606 2 the the DT cord-010092-uftc8inx 11606 3 period period NN cord-010092-uftc8inx 11606 4 under under IN cord-010092-uftc8inx 11606 5 study study NN cord-010092-uftc8inx 11606 6 , , , cord-010092-uftc8inx 11606 7 9,544 9,544 CD cord-010092-uftc8inx 11606 8 ATR ATR NNP cord-010092-uftc8inx 11606 9 were be VBD cord-010092-uftc8inx 11606 10 reported report VBN cord-010092-uftc8inx 11606 11 , , , cord-010092-uftc8inx 11606 12 of of IN cord-010092-uftc8inx 11606 13 which which WDT cord-010092-uftc8inx 11606 14 29 29 CD cord-010092-uftc8inx 11606 15 included include VBD cord-010092-uftc8inx 11606 16 unconsciousness unconsciousness NN cord-010092-uftc8inx 11606 17 and/or and/or CC cord-010092-uftc8inx 11606 18 convulsions convulsion NNS cord-010092-uftc8inx 11606 19 ( ( -LRB- cord-010092-uftc8inx 11606 20 0.3 0.3 CD cord-010092-uftc8inx 11606 21 % % NN cord-010092-uftc8inx 11606 22 ) ) -RRB- cord-010092-uftc8inx 11606 23 . . . cord-010092-uftc8inx 11607 1 Of of IN cord-010092-uftc8inx 11607 2 these these DT cord-010092-uftc8inx 11607 3 29 29 CD cord-010092-uftc8inx 11607 4 patients patient NNS cord-010092-uftc8inx 11607 5 , , , cord-010092-uftc8inx 11607 6 13 13 CD cord-010092-uftc8inx 11607 7 were be VBD cord-010092-uftc8inx 11607 8 females female NNS cord-010092-uftc8inx 11607 9 ( ( -LRB- cord-010092-uftc8inx 11607 10 44.8 44.8 CD cord-010092-uftc8inx 11607 11 % % NN cord-010092-uftc8inx 11607 12 ) ) -RRB- cord-010092-uftc8inx 11607 13 and and CC cord-010092-uftc8inx 11607 14 16 16 CD cord-010092-uftc8inx 11607 15 males male NNS cord-010092-uftc8inx 11607 16 ( ( -LRB- cord-010092-uftc8inx 11607 17 55.2 55.2 CD cord-010092-uftc8inx 11607 18 % % NN cord-010092-uftc8inx 11607 19 ) ) -RRB- cord-010092-uftc8inx 11607 20 . . . cord-010092-uftc8inx 11608 1 Unconsciousness unconsciousness NN cord-010092-uftc8inx 11608 2 alone alone RB cord-010092-uftc8inx 11608 3 was be VBD cord-010092-uftc8inx 11608 4 frequently frequently RB cord-010092-uftc8inx 11608 5 observed observe VBN cord-010092-uftc8inx 11608 6 ( ( -LRB- cord-010092-uftc8inx 11608 7 21 21 CD cord-010092-uftc8inx 11608 8 reports report NNS cord-010092-uftc8inx 11608 9 , , , cord-010092-uftc8inx 11608 10 72.4 72.4 CD cord-010092-uftc8inx 11608 11 % % NN cord-010092-uftc8inx 11608 12 ) ) -RRB- cord-010092-uftc8inx 11608 13 . . . cord-010092-uftc8inx 11609 1 Convulsions convulsion NNS cord-010092-uftc8inx 11609 2 were be VBD cord-010092-uftc8inx 11609 3 notified notify VBN cord-010092-uftc8inx 11609 4 in in IN cord-010092-uftc8inx 11609 5 8 8 CD cord-010092-uftc8inx 11609 6 reports report NNS cord-010092-uftc8inx 11609 7 ( ( -LRB- cord-010092-uftc8inx 11609 8 27.6 27.6 CD cord-010092-uftc8inx 11609 9 % % NN cord-010092-uftc8inx 11609 10 ) ) -RRB- cord-010092-uftc8inx 11609 11 and and CC cord-010092-uftc8inx 11609 12 were be VBD cord-010092-uftc8inx 11609 13 associated associate VBN cord-010092-uftc8inx 11609 14 with with IN cord-010092-uftc8inx 11609 15 unconsciousness unconsciousness NN cord-010092-uftc8inx 11609 16 in in IN cord-010092-uftc8inx 11609 17 2 2 CD cord-010092-uftc8inx 11609 18 of of IN cord-010092-uftc8inx 11609 19 them -PRON- PRP cord-010092-uftc8inx 11609 20 . . . cord-010092-uftc8inx 11610 1 The the DT cord-010092-uftc8inx 11610 2 diagnosis diagnosis NN cord-010092-uftc8inx 11610 3 of of IN cord-010092-uftc8inx 11610 4 seizure seizure NN cord-010092-uftc8inx 11610 5 , , , cord-010092-uftc8inx 11610 6 with with IN cord-010092-uftc8inx 11610 7 no no DT cord-010092-uftc8inx 11610 8 other other JJ cord-010092-uftc8inx 11610 9 clinical clinical JJ cord-010092-uftc8inx 11610 10 signs sign NNS cord-010092-uftc8inx 11610 11 , , , cord-010092-uftc8inx 11610 12 was be VBD cord-010092-uftc8inx 11610 13 established establish VBN cord-010092-uftc8inx 11610 14 in in IN cord-010092-uftc8inx 11610 15 2 2 CD cord-010092-uftc8inx 11610 16 cases case NNS cord-010092-uftc8inx 11610 17 ( ( -LRB- cord-010092-uftc8inx 11610 18 6.9 6.9 CD cord-010092-uftc8inx 11610 19 % % NN cord-010092-uftc8inx 11610 20 ) ) -RRB- cord-010092-uftc8inx 11610 21 . . . cord-010092-uftc8inx 11611 1 Unconsciousness unconsciousness NN cord-010092-uftc8inx 11611 2 and/or and/or CC cord-010092-uftc8inx 11611 3 convulsions convulsion NNS cord-010092-uftc8inx 11611 4 were be VBD cord-010092-uftc8inx 11611 5 present present JJ cord-010092-uftc8inx 11611 6 in in IN cord-010092-uftc8inx 11611 7 8 8 CD cord-010092-uftc8inx 11611 8 allergic allergic JJ cord-010092-uftc8inx 11611 9 reactions reaction NNS cord-010092-uftc8inx 11611 10 ( ( -LRB- cord-010092-uftc8inx 11611 11 27.6 27.6 CD cord-010092-uftc8inx 11611 12 % % NN cord-010092-uftc8inx 11611 13 ) ) -RRB- cord-010092-uftc8inx 11611 14 , , , cord-010092-uftc8inx 11611 15 4 4 CD cord-010092-uftc8inx 11611 16 cases case NNS cord-010092-uftc8inx 11611 17 of of IN cord-010092-uftc8inx 11611 18 transfusion transfusion NN cord-010092-uftc8inx 11611 19 - - HYPH cord-010092-uftc8inx 11611 20 associated associate VBN cord-010092-uftc8inx 11611 21 circulating circulate VBG cord-010092-uftc8inx 11611 22 overload overload NN cord-010092-uftc8inx 11611 23 ( ( -LRB- cord-010092-uftc8inx 11611 24 13.8 13.8 CD cord-010092-uftc8inx 11611 25 % % NN cord-010092-uftc8inx 11611 26 ) ) -RRB- cord-010092-uftc8inx 11611 27 , , , cord-010092-uftc8inx 11611 28 3 3 CD cord-010092-uftc8inx 11611 29 cases case NNS cord-010092-uftc8inx 11611 30 of of IN cord-010092-uftc8inx 11611 31 suspected suspect VBN cord-010092-uftc8inx 11611 32 transfusion transfusion NN cord-010092-uftc8inx 11611 33 - - HYPH cord-010092-uftc8inx 11611 34 transmitted transmit VBN cord-010092-uftc8inx 11611 35 bacterial bacterial JJ cord-010092-uftc8inx 11611 36 infections infection NNS cord-010092-uftc8inx 11611 37 and and CC cord-010092-uftc8inx 11611 38 2 2 CD cord-010092-uftc8inx 11611 39 hypertensive hypertensive JJ cord-010092-uftc8inx 11611 40 reactions reaction NNS cord-010092-uftc8inx 11611 41 . . . cord-010092-uftc8inx 11612 1 In in IN cord-010092-uftc8inx 11612 2 allergic allergic JJ cord-010092-uftc8inx 11612 3 ATRs atr NNS cord-010092-uftc8inx 11612 4 , , , cord-010092-uftc8inx 11612 5 unconsciousness unconsciousness NN cord-010092-uftc8inx 11612 6 was be VBD cord-010092-uftc8inx 11612 7 notified notify VBN cord-010092-uftc8inx 11612 8 in in IN cord-010092-uftc8inx 11612 9 7 7 CD cord-010092-uftc8inx 11612 10 cases case NNS cord-010092-uftc8inx 11612 11 and and CC cord-010092-uftc8inx 11612 12 unconsciousness unconsciousness NN cord-010092-uftc8inx 11612 13 associated associate VBN cord-010092-uftc8inx 11612 14 with with IN cord-010092-uftc8inx 11612 15 convulsions convulsion NNS cord-010092-uftc8inx 11612 16 in in IN cord-010092-uftc8inx 11612 17 one one CD cord-010092-uftc8inx 11612 18 . . . cord-010092-uftc8inx 11613 1 Twelve twelve CD cord-010092-uftc8inx 11613 2 ATRs atr NNS cord-010092-uftc8inx 11613 3 were be VBD cord-010092-uftc8inx 11613 4 severe severe JJ cord-010092-uftc8inx 11613 5 ( ( -LRB- cord-010092-uftc8inx 11613 6 41.4 41.4 CD cord-010092-uftc8inx 11613 7 % % NN cord-010092-uftc8inx 11613 8 ) ) -RRB- cord-010092-uftc8inx 11613 9 , , , cord-010092-uftc8inx 11613 10 10 10 CD cord-010092-uftc8inx 11613 11 were be VBD cord-010092-uftc8inx 11613 12 life life NN cord-010092-uftc8inx 11613 13 - - HYPH cord-010092-uftc8inx 11613 14 threatening threaten VBG cord-010092-uftc8inx 11613 15 ( ( -LRB- cord-010092-uftc8inx 11613 16 34.5 34.5 CD cord-010092-uftc8inx 11613 17 % % NN cord-010092-uftc8inx 11613 18 ) ) -RRB- cord-010092-uftc8inx 11613 19 and and CC cord-010092-uftc8inx 11613 20 in in IN cord-010092-uftc8inx 11613 21 4 4 CD cord-010092-uftc8inx 11613 22 cases case NNS cord-010092-uftc8inx 11613 23 , , , cord-010092-uftc8inx 11613 24 they -PRON- PRP cord-010092-uftc8inx 11613 25 resulted result VBD cord-010092-uftc8inx 11613 26 in in IN cord-010092-uftc8inx 11613 27 the the DT cord-010092-uftc8inx 11613 28 death death NN cord-010092-uftc8inx 11613 29 of of IN cord-010092-uftc8inx 11613 30 the the DT cord-010092-uftc8inx 11613 31 recipient recipient NN cord-010092-uftc8inx 11613 32 ( ( -LRB- cord-010092-uftc8inx 11613 33 13.8 13.8 CD cord-010092-uftc8inx 11613 34 % % NN cord-010092-uftc8inx 11613 35 ) ) -RRB- cord-010092-uftc8inx 11613 36 . . . cord-010092-uftc8inx 11614 1 Of of IN cord-010092-uftc8inx 11614 2 the the DT cord-010092-uftc8inx 11614 3 8 8 CD cord-010092-uftc8inx 11614 4 allergic allergic JJ cord-010092-uftc8inx 11614 5 ATRs atr NNS cord-010092-uftc8inx 11614 6 , , , cord-010092-uftc8inx 11614 7 4 4 CD cord-010092-uftc8inx 11614 8 were be VBD cord-010092-uftc8inx 11614 9 severe severe JJ cord-010092-uftc8inx 11614 10 and and CC cord-010092-uftc8inx 11614 11 4 4 CD cord-010092-uftc8inx 11614 12 life life NN cord-010092-uftc8inx 11614 13 - - HYPH cord-010092-uftc8inx 11614 14 threatening threaten VBG cord-010092-uftc8inx 11614 15 . . . cord-010092-uftc8inx 11615 1 Red red JJ cord-010092-uftc8inx 11615 2 blood blood NN cord-010092-uftc8inx 11615 3 cell cell NN cord-010092-uftc8inx 11615 4 concentrate concentrate NN cord-010092-uftc8inx 11615 5 was be VBD cord-010092-uftc8inx 11615 6 involved involve VBN cord-010092-uftc8inx 11615 7 in in IN cord-010092-uftc8inx 11615 8 15 15 CD cord-010092-uftc8inx 11615 9 ATRs atr NNS cord-010092-uftc8inx 11615 10 ( ( -LRB- cord-010092-uftc8inx 11615 11 51.7 51.7 CD cord-010092-uftc8inx 11615 12 % % NN cord-010092-uftc8inx 11615 13 ) ) -RRB- cord-010092-uftc8inx 11615 14 and and CC cord-010092-uftc8inx 11615 15 platelet platelet NN cord-010092-uftc8inx 11615 16 concentrate concentrate NN cord-010092-uftc8inx 11615 17 in in IN cord-010092-uftc8inx 11615 18 9 9 CD cord-010092-uftc8inx 11615 19 ( ( -LRB- cord-010092-uftc8inx 11615 20 31.1 31.1 CD cord-010092-uftc8inx 11615 21 % % NN cord-010092-uftc8inx 11615 22 ) ) -RRB- cord-010092-uftc8inx 11615 23 , , , cord-010092-uftc8inx 11615 24 including include VBG cord-010092-uftc8inx 11615 25 5 5 CD cord-010092-uftc8inx 11615 26 cases case NNS cord-010092-uftc8inx 11615 27 with with IN cord-010092-uftc8inx 11615 28 apheresis apheresis NN cord-010092-uftc8inx 11615 29 platelet platelet NN cord-010092-uftc8inx 11615 30 concentrate concentrate NN cord-010092-uftc8inx 11615 31 and and CC cord-010092-uftc8inx 11615 32 4 4 CD cord-010092-uftc8inx 11615 33 cases case NNS cord-010092-uftc8inx 11615 34 with with IN cord-010092-uftc8inx 11615 35 pooled pool VBN cord-010092-uftc8inx 11615 36 platelet platelet NN cord-010092-uftc8inx 11615 37 concentrate concentrate NN cord-010092-uftc8inx 11615 38 . . . cord-010092-uftc8inx 11616 1 Fresh fresh JJ cord-010092-uftc8inx 11616 2 frozen frozen JJ cord-010092-uftc8inx 11616 3 plasma plasma NN cord-010092-uftc8inx 11616 4 was be VBD cord-010092-uftc8inx 11616 5 involved involve VBN cord-010092-uftc8inx 11616 6 in in IN cord-010092-uftc8inx 11616 7 5 5 CD cord-010092-uftc8inx 11616 8 ATRs atr NNS cord-010092-uftc8inx 11616 9 ( ( -LRB- cord-010092-uftc8inx 11616 10 17.2 17.2 CD cord-010092-uftc8inx 11616 11 % % NN cord-010092-uftc8inx 11616 12 ) ) -RRB- cord-010092-uftc8inx 11616 13 . . . cord-010092-uftc8inx 11617 1 Nevertheless nevertheless RB cord-010092-uftc8inx 11617 2 , , , cord-010092-uftc8inx 11617 3 the the DT cord-010092-uftc8inx 11617 4 imputability imputability NN cord-010092-uftc8inx 11617 5 of of IN cord-010092-uftc8inx 11617 6 the the DT cord-010092-uftc8inx 11617 7 blood blood NN cord-010092-uftc8inx 11617 8 product product NN cord-010092-uftc8inx 11617 9 was be VBD cord-010092-uftc8inx 11617 10 excluded exclude VBN cord-010092-uftc8inx 11617 11 or or CC cord-010092-uftc8inx 11617 12 unlikely unlikely JJ cord-010092-uftc8inx 11617 13 in in IN cord-010092-uftc8inx 11617 14 11 11 CD cord-010092-uftc8inx 11617 15 ATRs atr NNS cord-010092-uftc8inx 11617 16 ( ( -LRB- cord-010092-uftc8inx 11617 17 37.9 37.9 CD cord-010092-uftc8inx 11617 18 % % NN cord-010092-uftc8inx 11617 19 ) ) -RRB- cord-010092-uftc8inx 11617 20 . . . cord-010092-uftc8inx 11618 1 In in IN cord-010092-uftc8inx 11618 2 the the DT cord-010092-uftc8inx 11618 3 3 3 CD cord-010092-uftc8inx 11618 4 suspected suspect VBN cord-010092-uftc8inx 11618 5 transfusion transfusion NN cord-010092-uftc8inx 11618 6 - - HYPH cord-010092-uftc8inx 11618 7 transmitted transmit VBN cord-010092-uftc8inx 11618 8 bacterial bacterial JJ cord-010092-uftc8inx 11618 9 infections infection NNS cord-010092-uftc8inx 11618 10 , , , cord-010092-uftc8inx 11618 11 the the DT cord-010092-uftc8inx 11618 12 imputability imputability NN cord-010092-uftc8inx 11618 13 of of IN cord-010092-uftc8inx 11618 14 the the DT cord-010092-uftc8inx 11618 15 transfusion transfusion NN cord-010092-uftc8inx 11618 16 was be VBD cord-010092-uftc8inx 11618 17 ultimately ultimately RB cord-010092-uftc8inx 11618 18 excluded exclude VBN cord-010092-uftc8inx 11618 19 after after IN cord-010092-uftc8inx 11618 20 a a DT cord-010092-uftc8inx 11618 21 negative negative JJ cord-010092-uftc8inx 11618 22 result result NN cord-010092-uftc8inx 11618 23 was be VBD cord-010092-uftc8inx 11618 24 obtained obtain VBN cord-010092-uftc8inx 11618 25 in in IN cord-010092-uftc8inx 11618 26 the the DT cord-010092-uftc8inx 11618 27 bacterial bacterial JJ cord-010092-uftc8inx 11618 28 culture culture NN cord-010092-uftc8inx 11618 29 of of IN cord-010092-uftc8inx 11618 30 the the DT cord-010092-uftc8inx 11618 31 blood blood NN cord-010092-uftc8inx 11618 32 product product NN cord-010092-uftc8inx 11618 33 . . . cord-010092-uftc8inx 11619 1 The the DT cord-010092-uftc8inx 11619 2 imputability imputability NN cord-010092-uftc8inx 11619 3 of of IN cord-010092-uftc8inx 11619 4 the the DT cord-010092-uftc8inx 11619 5 blood blood NN cord-010092-uftc8inx 11619 6 product product NN cord-010092-uftc8inx 11619 7 was be VBD cord-010092-uftc8inx 11619 8 probable probable JJ cord-010092-uftc8inx 11619 9 or or CC cord-010092-uftc8inx 11619 10 possible possible JJ cord-010092-uftc8inx 11619 11 in in IN cord-010092-uftc8inx 11619 12 7 7 CD cord-010092-uftc8inx 11619 13 and and CC cord-010092-uftc8inx 11619 14 9 9 CD cord-010092-uftc8inx 11619 15 ATRs atr NNS cord-010092-uftc8inx 11619 16 respectively respectively RB cord-010092-uftc8inx 11619 17 , , , cord-010092-uftc8inx 11619 18 but but CC cord-010092-uftc8inx 11619 19 was be VBD cord-010092-uftc8inx 11619 20 certain certain JJ cord-010092-uftc8inx 11619 21 in in IN cord-010092-uftc8inx 11619 22 only only RB cord-010092-uftc8inx 11619 23 2 2 CD cord-010092-uftc8inx 11619 24 ATRs atr NNS cord-010092-uftc8inx 11619 25 . . . cord-010092-uftc8inx 11620 1 Summary Summary NNP cord-010092-uftc8inx 11620 2 / / SYM cord-010092-uftc8inx 11620 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 11620 4 : : : cord-010092-uftc8inx 11621 1 Unconsciousness unconsciousness NN cord-010092-uftc8inx 11621 2 and/or and/or CC cord-010092-uftc8inx 11621 3 convulsions convulsion NNS cord-010092-uftc8inx 11621 4 were be VBD cord-010092-uftc8inx 11621 5 rarely rarely RB cord-010092-uftc8inx 11621 6 observed observe VBN cord-010092-uftc8inx 11621 7 in in IN cord-010092-uftc8inx 11621 8 ATRs atr NNS cord-010092-uftc8inx 11621 9 notified notify VBN cord-010092-uftc8inx 11621 10 in in IN cord-010092-uftc8inx 11621 11 transfused transfuse VBN cord-010092-uftc8inx 11621 12 patients patient NNS cord-010092-uftc8inx 11621 13 . . . cord-010092-uftc8inx 11622 1 Nevertheless nevertheless RB cord-010092-uftc8inx 11622 2 , , , cord-010092-uftc8inx 11622 3 the the DT cord-010092-uftc8inx 11622 4 presence presence NN cord-010092-uftc8inx 11622 5 of of IN cord-010092-uftc8inx 11622 6 these these DT cord-010092-uftc8inx 11622 7 signs sign NNS cord-010092-uftc8inx 11622 8 highlights highlight VBZ cord-010092-uftc8inx 11622 9 the the DT cord-010092-uftc8inx 11622 10 seriousness seriousness NN cord-010092-uftc8inx 11622 11 of of IN cord-010092-uftc8inx 11622 12 the the DT cord-010092-uftc8inx 11622 13 ATR ATR NNP cord-010092-uftc8inx 11622 14 ( ( -LRB- cord-010092-uftc8inx 11622 15 26 26 CD cord-010092-uftc8inx 11622 16 ARs ar NNS cord-010092-uftc8inx 11622 17 , , , cord-010092-uftc8inx 11622 18 89.7 89.7 CD cord-010092-uftc8inx 11622 19 % % NN cord-010092-uftc8inx 11622 20 ) ) -RRB- cord-010092-uftc8inx 11622 21 . . . cord-010092-uftc8inx 11623 1 Lastly lastly RB cord-010092-uftc8inx 11623 2 , , , cord-010092-uftc8inx 11623 3 the the DT cord-010092-uftc8inx 11623 4 imputability imputability NN cord-010092-uftc8inx 11623 5 of of IN cord-010092-uftc8inx 11623 6 the the DT cord-010092-uftc8inx 11623 7 blood blood NN cord-010092-uftc8inx 11623 8 product product NN cord-010092-uftc8inx 11623 9 was be VBD cord-010092-uftc8inx 11623 10 often often RB cord-010092-uftc8inx 11623 11 excluded exclude VBN cord-010092-uftc8inx 11623 12 or or CC cord-010092-uftc8inx 11623 13 unlikely unlikely JJ cord-010092-uftc8inx 11623 14 . . . cord-010092-uftc8inx 11624 1 In in IN cord-010092-uftc8inx 11624 2 the the DT cord-010092-uftc8inx 11624 3 multivariate multivariate JJ cord-010092-uftc8inx 11624 4 Cox Cox NNP cord-010092-uftc8inx 11624 5 model model NN cord-010092-uftc8inx 11624 6 for for IN cord-010092-uftc8inx 11624 7 the the DT cord-010092-uftc8inx 11624 8 effect effect NN cord-010092-uftc8inx 11624 9 of of IN cord-010092-uftc8inx 11624 10 LPI lpi NN cord-010092-uftc8inx 11624 11 on on IN cord-010092-uftc8inx 11624 12 overall overall JJ cord-010092-uftc8inx 11624 13 survival survival NN cord-010092-uftc8inx 11624 14 , , , cord-010092-uftc8inx 11624 15 adjusted adjust VBN cord-010092-uftc8inx 11624 16 for for IN cord-010092-uftc8inx 11624 17 age age NN cord-010092-uftc8inx 11624 18 and and CC cord-010092-uftc8inx 11624 19 IPSS IPSS NNP cord-010092-uftc8inx 11624 20 - - HYPH cord-010092-uftc8inx 11624 21 R r NN cord-010092-uftc8inx 11624 22 category category NN cord-010092-uftc8inx 11624 23 , , , cord-010092-uftc8inx 11624 24 elevated elevated JJ cord-010092-uftc8inx 11624 25 LPI lpi NN cord-010092-uftc8inx 11624 26 levels level NNS cord-010092-uftc8inx 11624 27 were be VBD cord-010092-uftc8inx 11624 28 associated associate VBN cord-010092-uftc8inx 11624 29 with with IN cord-010092-uftc8inx 11624 30 inferior inferior JJ cord-010092-uftc8inx 11624 31 overall overall JJ cord-010092-uftc8inx 11624 32 survival survival NN cord-010092-uftc8inx 11624 33 ( ( -LRB- cord-010092-uftc8inx 11624 34 HR HR NNP cord-010092-uftc8inx 11624 35 3.0 3.0 CD cord-010092-uftc8inx 11624 36 , , , cord-010092-uftc8inx 11624 37 95 95 CD cord-010092-uftc8inx 11624 38 % % NN cord-010092-uftc8inx 11624 39 CI CI NNP cord-010092-uftc8inx 11624 40 1.5 1.5 CD cord-010092-uftc8inx 11624 41 - - SYM cord-010092-uftc8inx 11624 42 5.7 5.7 CD cord-010092-uftc8inx 11624 43 , , , cord-010092-uftc8inx 11624 44 P p NN cord-010092-uftc8inx 11624 45 = = SYM cord-010092-uftc8inx 11624 46 0.001 0.001 CD cord-010092-uftc8inx 11624 47 ) ) -RRB- cord-010092-uftc8inx 11624 48 . . . cord-010092-uftc8inx 11625 1 This this DT cord-010092-uftc8inx 11625 2 effect effect NN cord-010092-uftc8inx 11625 3 was be VBD cord-010092-uftc8inx 11625 4 most most RBS cord-010092-uftc8inx 11625 5 pronounced pronounce VBN cord-010092-uftc8inx 11625 6 in in IN cord-010092-uftc8inx 11625 7 the the DT cord-010092-uftc8inx 11625 8 TD TD NNP cord-010092-uftc8inx 11625 9 - - HYPH cord-010092-uftc8inx 11625 10 RS rs NN cord-010092-uftc8inx 11625 11 subgroup subgroup NN cord-010092-uftc8inx 11625 12 ( ( -LRB- cord-010092-uftc8inx 11625 13 HR HR NNP cord-010092-uftc8inx 11625 14 6.0 6.0 CD cord-010092-uftc8inx 11625 15 , , , cord-010092-uftc8inx 11625 16 95 95 CD cord-010092-uftc8inx 11625 17 % % NN cord-010092-uftc8inx 11625 18 CI CI NNP cord-010092-uftc8inx 11625 19 2.2 2.2 CD cord-010092-uftc8inx 11625 20 - - HYPH cord-010092-uftc8inx 11625 21 16.2 16.2 CD cord-010092-uftc8inx 11625 22 , , , cord-010092-uftc8inx 11626 1 P p NN cord-010092-uftc8inx 11626 2 < < XX cord-010092-uftc8inx 11626 3 0.001 0.001 CD cord-010092-uftc8inx 11626 4 ) ) -RRB- cord-010092-uftc8inx 11626 5 . . . cord-010092-uftc8inx 11627 1 Similarly similarly RB cord-010092-uftc8inx 11627 2 , , , cord-010092-uftc8inx 11627 3 elevated elevated JJ cord-010092-uftc8inx 11627 4 LPI lpi NN cord-010092-uftc8inx 11627 5 levels level NNS cord-010092-uftc8inx 11627 6 were be VBD cord-010092-uftc8inx 11627 7 associated associate VBN cord-010092-uftc8inx 11627 8 with with IN cord-010092-uftc8inx 11627 9 inferior inferior JJ cord-010092-uftc8inx 11627 10 PFS PFS NNP cord-010092-uftc8inx 11627 11 ( ( -LRB- cord-010092-uftc8inx 11627 12 HR HR NNP cord-010092-uftc8inx 11627 13 3.4 3.4 CD cord-010092-uftc8inx 11627 14 , , , cord-010092-uftc8inx 11627 15 95 95 CD cord-010092-uftc8inx 11627 16 % % NN cord-010092-uftc8inx 11627 17 CI CI NNP cord-010092-uftc8inx 11627 18 1.9 1.9 CD cord-010092-uftc8inx 11627 19 - - SYM cord-010092-uftc8inx 11627 20 6.3 6.3 CD cord-010092-uftc8inx 11627 21 , , , cord-010092-uftc8inx 11627 22 P p NN cord-010092-uftc8inx 11627 23 < < XX cord-010092-uftc8inx 11627 24 0.001 0.001 CD cord-010092-uftc8inx 11627 25 ) ) -RRB- cord-010092-uftc8inx 11627 26 for for IN cord-010092-uftc8inx 11627 27 the the DT cord-010092-uftc8inx 11627 28 whole whole JJ cord-010092-uftc8inx 11627 29 study study NN cord-010092-uftc8inx 11627 30 population population NN cord-010092-uftc8inx 11627 31 and and CC cord-010092-uftc8inx 11627 32 the the DT cord-010092-uftc8inx 11627 33 TD TD NNP cord-010092-uftc8inx 11627 34 - - HYPH cord-010092-uftc8inx 11627 35 RS rs NN cord-010092-uftc8inx 11627 36 subgroup subgroup NN cord-010092-uftc8inx 11627 37 ( ( -LRB- cord-010092-uftc8inx 11627 38 HR HR NNP cord-010092-uftc8inx 11627 39 8.2 8.2 CD cord-010092-uftc8inx 11627 40 , , , cord-010092-uftc8inx 11627 41 95 95 CD cord-010092-uftc8inx 11627 42 % % NN cord-010092-uftc8inx 11627 43 CI CI NNP cord-010092-uftc8inx 11627 44 3.4 3.4 CD cord-010092-uftc8inx 11627 45 - - HYPH cord-010092-uftc8inx 11627 46 21.0 21.0 CD cord-010092-uftc8inx 11627 47 , , , cord-010092-uftc8inx 11627 48 P p NN cord-010092-uftc8inx 11627 49 < < XX cord-010092-uftc8inx 11627 50 0.001 0.001 CD cord-010092-uftc8inx 11627 51 ) ) -RRB- cord-010092-uftc8inx 11627 52 . . . cord-010092-uftc8inx 11628 1 In in IN cord-010092-uftc8inx 11628 2 total total JJ cord-010092-uftc8inx 11628 3 16 16 CD cord-010092-uftc8inx 11628 4 patients patient NNS cord-010092-uftc8inx 11628 5 received receive VBD cord-010092-uftc8inx 11628 6 iron iron NN cord-010092-uftc8inx 11628 7 chelation chelation NN cord-010092-uftc8inx 11628 8 during during IN cord-010092-uftc8inx 11628 9 the the DT cord-010092-uftc8inx 11628 10 sample sample NN cord-010092-uftc8inx 11628 11 collection collection NN cord-010092-uftc8inx 11628 12 period period NN cord-010092-uftc8inx 11628 13 ( ( -LRB- cord-010092-uftc8inx 11628 14 11 11 CD cord-010092-uftc8inx 11628 15 patients patient NNS cord-010092-uftc8inx 11628 16 deferasirox deferasirox NN cord-010092-uftc8inx 11628 17 , , , cord-010092-uftc8inx 11628 18 5 5 CD cord-010092-uftc8inx 11628 19 patients patient NNS cord-010092-uftc8inx 11628 20 desferrioxamine desferrioxamine NN cord-010092-uftc8inx 11628 21 ) ) -RRB- cord-010092-uftc8inx 11628 22 . . . cord-010092-uftc8inx 11629 1 LPI LPI NNP cord-010092-uftc8inx 11629 2 levels level NNS cord-010092-uftc8inx 11629 3 were be VBD cord-010092-uftc8inx 11629 4 normal normal JJ cord-010092-uftc8inx 11629 5 in in IN cord-010092-uftc8inx 11629 6 14 14 CD cord-010092-uftc8inx 11629 7 out out IN cord-010092-uftc8inx 11629 8 of of IN cord-010092-uftc8inx 11629 9 the the DT cord-010092-uftc8inx 11629 10 17 17 CD cord-010092-uftc8inx 11629 11 samples sample NNS cord-010092-uftc8inx 11629 12 collected collect VBN cord-010092-uftc8inx 11629 13 during during IN cord-010092-uftc8inx 11629 14 deferasirox deferasirox NNP cord-010092-uftc8inx 11629 15 treatment treatment NN cord-010092-uftc8inx 11629 16 and and CC cord-010092-uftc8inx 11629 17 in in IN cord-010092-uftc8inx 11629 18 2 2 CD cord-010092-uftc8inx 11629 19 out out IN cord-010092-uftc8inx 11629 20 of of IN cord-010092-uftc8inx 11629 21 5 5 CD cord-010092-uftc8inx 11629 22 samples sample NNS cord-010092-uftc8inx 11629 23 collected collect VBN cord-010092-uftc8inx 11629 24 during during IN cord-010092-uftc8inx 11629 25 desferrioxamine desferrioxamine JJ cord-010092-uftc8inx 11629 26 treatment treatment NN cord-010092-uftc8inx 11629 27 . . . cord-010092-uftc8inx 11630 1 Summary Summary NNP cord-010092-uftc8inx 11630 2 / / SYM cord-010092-uftc8inx 11630 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 11630 4 : : : cord-010092-uftc8inx 11631 1 Transfusion transfusion NN cord-010092-uftc8inx 11631 2 dependency dependency NN cord-010092-uftc8inx 11631 3 is be VBZ cord-010092-uftc8inx 11631 4 associated associate VBN cord-010092-uftc8inx 11631 5 with with IN cord-010092-uftc8inx 11631 6 the the DT cord-010092-uftc8inx 11631 7 presence presence NN cord-010092-uftc8inx 11631 8 of of IN cord-010092-uftc8inx 11631 9 toxic toxic JJ cord-010092-uftc8inx 11631 10 iron iron NN cord-010092-uftc8inx 11631 11 species specie NNS cord-010092-uftc8inx 11631 12 and and CC cord-010092-uftc8inx 11631 13 inferior inferior JJ cord-010092-uftc8inx 11631 14 overall overall NN cord-010092-uftc8inx 11631 15 and and CC cord-010092-uftc8inx 11631 16 progression progression NN cord-010092-uftc8inx 11631 17 - - HYPH cord-010092-uftc8inx 11631 18 free free JJ cord-010092-uftc8inx 11631 19 survival survival NN cord-010092-uftc8inx 11631 20 in in IN cord-010092-uftc8inx 11631 21 lower low JJR cord-010092-uftc8inx 11631 22 - - HYPH cord-010092-uftc8inx 11631 23 risk risk NN cord-010092-uftc8inx 11631 24 MDS MDS NNP cord-010092-uftc8inx 11631 25 patients patient NNS cord-010092-uftc8inx 11631 26 . . . cord-010092-uftc8inx 11632 1 In in IN cord-010092-uftc8inx 11632 2 TD TD NNP cord-010092-uftc8inx 11632 3 - - HYPH cord-010092-uftc8inx 11632 4 RS rs NN cord-010092-uftc8inx 11632 5 patients patient NNS cord-010092-uftc8inx 11632 6 the the DT cord-010092-uftc8inx 11632 7 effects effect NNS cord-010092-uftc8inx 11632 8 were be VBD cord-010092-uftc8inx 11632 9 most most RBS cord-010092-uftc8inx 11632 10 pronounced pronounce VBN cord-010092-uftc8inx 11632 11 indicating indicate VBG cord-010092-uftc8inx 11632 12 ineffective ineffective JJ cord-010092-uftc8inx 11632 13 erythropoiesis erythropoiesis NN cord-010092-uftc8inx 11632 14 leading lead VBG cord-010092-uftc8inx 11632 15 to to IN cord-010092-uftc8inx 11632 16 additional additional JJ cord-010092-uftc8inx 11632 17 iron iron NN cord-010092-uftc8inx 11632 18 toxicity toxicity NN cord-010092-uftc8inx 11632 19 . . . cord-010092-uftc8inx 11633 1 Background background NN cord-010092-uftc8inx 11633 2 : : : cord-010092-uftc8inx 11634 1 Post post JJ cord-010092-uftc8inx 11634 2 - - JJ cord-010092-uftc8inx 11634 3 transfusion transfusion JJ cord-010092-uftc8inx 11634 4 immunomodulation immunomodulation NN cord-010092-uftc8inx 11634 5 has have VBZ cord-010092-uftc8inx 11634 6 been be VBN cord-010092-uftc8inx 11634 7 reported report VBN cord-010092-uftc8inx 11634 8 to to TO cord-010092-uftc8inx 11634 9 contribute contribute VB cord-010092-uftc8inx 11634 10 to to IN cord-010092-uftc8inx 11634 11 poor poor JJ cord-010092-uftc8inx 11634 12 patient patient NN cord-010092-uftc8inx 11634 13 outcomes outcome NNS cord-010092-uftc8inx 11634 14 . . . cord-010092-uftc8inx 11635 1 Clinically clinically RB cord-010092-uftc8inx 11635 2 relevant relevant JJ cord-010092-uftc8inx 11635 3 transfusion transfusion NN cord-010092-uftc8inx 11635 4 models model NNS cord-010092-uftc8inx 11635 5 are be VBP cord-010092-uftc8inx 11635 6 needed need VBN cord-010092-uftc8inx 11635 7 to to TO cord-010092-uftc8inx 11635 8 improve improve VB cord-010092-uftc8inx 11635 9 our -PRON- PRP$ cord-010092-uftc8inx 11635 10 understanding understanding NN cord-010092-uftc8inx 11635 11 of of IN cord-010092-uftc8inx 11635 12 underlying underlie VBG cord-010092-uftc8inx 11635 13 mechanisms mechanism NNS cord-010092-uftc8inx 11635 14 . . . cord-010092-uftc8inx 11636 1 Sheep sheep NN cord-010092-uftc8inx 11636 2 transfusion transfusion NN cord-010092-uftc8inx 11636 3 models model NNS cord-010092-uftc8inx 11636 4 are be VBP cord-010092-uftc8inx 11636 5 of of IN cord-010092-uftc8inx 11636 6 increasing increase VBG cord-010092-uftc8inx 11636 7 importance importance NN cord-010092-uftc8inx 11636 8 in in IN cord-010092-uftc8inx 11636 9 blood blood NN cord-010092-uftc8inx 11636 10 transfusion transfusion NN cord-010092-uftc8inx 11636 11 research research NN cord-010092-uftc8inx 11636 12 as as IN cord-010092-uftc8inx 11636 13 they -PRON- PRP cord-010092-uftc8inx 11636 14 provide provide VBP cord-010092-uftc8inx 11636 15 several several JJ cord-010092-uftc8inx 11636 16 advantages advantage NNS cord-010092-uftc8inx 11636 17 over over IN cord-010092-uftc8inx 11636 18 small small JJ cord-010092-uftc8inx 11636 19 animals animal NNS cord-010092-uftc8inx 11636 20 , , , cord-010092-uftc8inx 11636 21 including include VBG cord-010092-uftc8inx 11636 22 their -PRON- PRP$ cord-010092-uftc8inx 11636 23 size size NN cord-010092-uftc8inx 11636 24 , , , cord-010092-uftc8inx 11636 25 anatomy anatomy NN cord-010092-uftc8inx 11636 26 , , , cord-010092-uftc8inx 11636 27 physiology physiology NN cord-010092-uftc8inx 11636 28 and and CC cord-010092-uftc8inx 11636 29 similar similar JJ cord-010092-uftc8inx 11636 30 blood blood NN cord-010092-uftc8inx 11636 31 volume volume NN cord-010092-uftc8inx 11636 32 compared compare VBN cord-010092-uftc8inx 11636 33 to to IN cord-010092-uftc8inx 11636 34 human human NN cord-010092-uftc8inx 11636 35 . . . cord-010092-uftc8inx 11637 1 A a DT cord-010092-uftc8inx 11637 2 current current JJ cord-010092-uftc8inx 11637 3 limitation limitation NN cord-010092-uftc8inx 11637 4 of of IN cord-010092-uftc8inx 11637 5 sheep sheep NN cord-010092-uftc8inx 11637 6 transfusion transfusion NN cord-010092-uftc8inx 11637 7 models model NNS cord-010092-uftc8inx 11637 8 is be VBZ cord-010092-uftc8inx 11637 9 the the DT cord-010092-uftc8inx 11637 10 lack lack NN cord-010092-uftc8inx 11637 11 of of IN cord-010092-uftc8inx 11637 12 characterisation characterisation NN cord-010092-uftc8inx 11637 13 of of IN cord-010092-uftc8inx 11637 14 the the DT cord-010092-uftc8inx 11637 15 sheep sheep NN cord-010092-uftc8inx 11637 16 immune immune NN cord-010092-uftc8inx 11637 17 system system NN cord-010092-uftc8inx 11637 18 . . . cord-010092-uftc8inx 11638 1 Understanding understand VBG cord-010092-uftc8inx 11638 2 the the DT cord-010092-uftc8inx 11638 3 sheep sheep NNS cord-010092-uftc8inx 11638 4 immunology immunology NN cord-010092-uftc8inx 11638 5 is be VBZ cord-010092-uftc8inx 11638 6 necessary necessary JJ cord-010092-uftc8inx 11638 7 to to TO cord-010092-uftc8inx 11638 8 advance advance VB cord-010092-uftc8inx 11638 9 sheep sheep NN cord-010092-uftc8inx 11638 10 transfusion transfusion NN cord-010092-uftc8inx 11638 11 models model NNS cord-010092-uftc8inx 11638 12 , , , cord-010092-uftc8inx 11638 13 identify identify VB cord-010092-uftc8inx 11638 14 mechanisms mechanism NNS cord-010092-uftc8inx 11638 15 that that WDT cord-010092-uftc8inx 11638 16 contribute contribute VBP cord-010092-uftc8inx 11638 17 to to IN cord-010092-uftc8inx 11638 18 post post JJ cord-010092-uftc8inx 11638 19 - - JJ cord-010092-uftc8inx 11638 20 transfusion transfusion JJ cord-010092-uftc8inx 11638 21 immunomodulation immunomodulation NN cord-010092-uftc8inx 11638 22 and and CC cord-010092-uftc8inx 11638 23 facilitate facilitate VB cord-010092-uftc8inx 11638 24 the the DT cord-010092-uftc8inx 11638 25 translation translation NN cord-010092-uftc8inx 11638 26 of of IN cord-010092-uftc8inx 11638 27 findings finding NNS cord-010092-uftc8inx 11638 28 into into IN cord-010092-uftc8inx 11638 29 clinical clinical JJ cord-010092-uftc8inx 11638 30 settings setting NNS cord-010092-uftc8inx 11638 31 . . . cord-010092-uftc8inx 11639 1 Aims aim VBZ cord-010092-uftc8inx 11639 2 : : : cord-010092-uftc8inx 11640 1 To to TO cord-010092-uftc8inx 11640 2 characterise characterise VB cord-010092-uftc8inx 11640 3 the the DT cord-010092-uftc8inx 11640 4 sheep sheep NN cord-010092-uftc8inx 11640 5 leukocyte leukocyte NN cord-010092-uftc8inx 11640 6 inflammatory inflammatory JJ cord-010092-uftc8inx 11640 7 responses response NNS cord-010092-uftc8inx 11640 8 to to IN cord-010092-uftc8inx 11640 9 in in FW cord-010092-uftc8inx 11640 10 vitro vitro FW cord-010092-uftc8inx 11640 11 lipopolysaccharide lipopolysaccharide NN cord-010092-uftc8inx 11640 12 ( ( -LRB- cord-010092-uftc8inx 11640 13 LPS LPS NNP cord-010092-uftc8inx 11640 14 ) ) -RRB- cord-010092-uftc8inx 11640 15 challenge challenge NN cord-010092-uftc8inx 11640 16 in in IN cord-010092-uftc8inx 11640 17 EDTA EDTA NNP cord-010092-uftc8inx 11640 18 and and CC cord-010092-uftc8inx 11640 19 heparinized heparinize VBD cord-010092-uftc8inx 11640 20 whole whole JJ cord-010092-uftc8inx 11640 21 blood blood NN cord-010092-uftc8inx 11640 22 . . . cord-010092-uftc8inx 11641 1 Methods method NNS cord-010092-uftc8inx 11641 2 : : : cord-010092-uftc8inx 11641 3 EDTA EDTA NNP cord-010092-uftc8inx 11641 4 and and CC cord-010092-uftc8inx 11641 5 heparinized heparinized JJ cord-010092-uftc8inx 11641 6 sheep sheep NN cord-010092-uftc8inx 11641 7 whole whole JJ cord-010092-uftc8inx 11641 8 blood blood NN cord-010092-uftc8inx 11641 9 ( ( -LRB- cord-010092-uftc8inx 11641 10 n n NN cord-010092-uftc8inx 11641 11 = = SYM cord-010092-uftc8inx 11641 12 4 4 CD cord-010092-uftc8inx 11641 13 of of IN cord-010092-uftc8inx 11641 14 each each DT cord-010092-uftc8inx 11641 15 ) ) -RRB- cord-010092-uftc8inx 11641 16 was be VBD cord-010092-uftc8inx 11641 17 cultured culture VBN cord-010092-uftc8inx 11641 18 with with IN cord-010092-uftc8inx 11641 19 RPMI RPMI NNP cord-010092-uftc8inx 11641 20 media medium NNS cord-010092-uftc8inx 11641 21 ( ( -LRB- cord-010092-uftc8inx 11641 22 37 37 CD cord-010092-uftc8inx 11641 23 ° ° NN cord-010092-uftc8inx 11641 24 C c NN cord-010092-uftc8inx 11641 25 , , , cord-010092-uftc8inx 11641 26 5 5 CD cord-010092-uftc8inx 11641 27 % % NN cord-010092-uftc8inx 11641 28 CO co NN cord-010092-uftc8inx 11641 29 2 2 CD cord-010092-uftc8inx 11641 30 ) ) -RRB- cord-010092-uftc8inx 11641 31 alone alone RB cord-010092-uftc8inx 11641 32 or or CC cord-010092-uftc8inx 11641 33 with with IN cord-010092-uftc8inx 11641 34 the the DT cord-010092-uftc8inx 11641 35 addition addition NN cord-010092-uftc8inx 11641 36 of of IN cord-010092-uftc8inx 11641 37 LPS LPS NNP cord-010092-uftc8inx 11641 38 ( ( -LRB- cord-010092-uftc8inx 11641 39 1 1 CD cord-010092-uftc8inx 11641 40 - - SYM cord-010092-uftc8inx 11641 41 100 100 CD cord-010092-uftc8inx 11641 42 lg lg NNP cord-010092-uftc8inx 11641 43 / / SYM cord-010092-uftc8inx 11641 44 mL ml NN cord-010092-uftc8inx 11641 45 ; ; , cord-010092-uftc8inx 11641 46 derived derive VBN cord-010092-uftc8inx 11641 47 from from IN cord-010092-uftc8inx 11641 48 Escherichia Escherichia NNP cord-010092-uftc8inx 11641 49 coli coli VBZ cord-010092-uftc8inx 11641 50 055 055 CD cord-010092-uftc8inx 11641 51 : : : cord-010092-uftc8inx 11641 52 B5 b5 NN cord-010092-uftc8inx 11641 53 ) ) -RRB- cord-010092-uftc8inx 11641 54 . . . cord-010092-uftc8inx 11642 1 The the DT cord-010092-uftc8inx 11642 2 inflammatory inflammatory JJ cord-010092-uftc8inx 11642 3 response response NN cord-010092-uftc8inx 11642 4 was be VBD cord-010092-uftc8inx 11642 5 assessed assess VBN cord-010092-uftc8inx 11642 6 after after IN cord-010092-uftc8inx 11642 7 2 2 CD cord-010092-uftc8inx 11642 8 h h NN cord-010092-uftc8inx 11642 9 ( ( -LRB- cord-010092-uftc8inx 11642 10 h h NNP cord-010092-uftc8inx 11642 11 ) ) -RRB- cord-010092-uftc8inx 11642 12 , , , cord-010092-uftc8inx 11642 13 6 6 CD cord-010092-uftc8inx 11642 14 h h NN cord-010092-uftc8inx 11642 15 , , , cord-010092-uftc8inx 11642 16 12 12 CD cord-010092-uftc8inx 11642 17 h h NN cord-010092-uftc8inx 11642 18 , , , cord-010092-uftc8inx 11642 19 24 24 CD cord-010092-uftc8inx 11642 20 h h NNP cord-010092-uftc8inx 11642 21 , , , cord-010092-uftc8inx 11642 22 36 36 CD cord-010092-uftc8inx 11642 23 h h NN cord-010092-uftc8inx 11642 24 and and CC cord-010092-uftc8inx 11642 25 48 48 CD cord-010092-uftc8inx 11642 26 h. h. NN cord-010092-uftc8inx 11642 27 Supernatant Supernatant NNP cord-010092-uftc8inx 11642 28 was be VBD cord-010092-uftc8inx 11642 29 harvested harvest VBN cord-010092-uftc8inx 11642 30 at at IN cord-010092-uftc8inx 11642 31 each each DT cord-010092-uftc8inx 11642 32 time time NN cord-010092-uftc8inx 11642 33 point point NN cord-010092-uftc8inx 11642 34 and and CC cord-010092-uftc8inx 11642 35 stored store VBN cord-010092-uftc8inx 11642 36 at at IN cord-010092-uftc8inx 11642 37 À80 À80 NNP cord-010092-uftc8inx 11642 38 ° ° NN cord-010092-uftc8inx 11642 39 C C NNP cord-010092-uftc8inx 11642 40 . . . cord-010092-uftc8inx 11643 1 Inflammatory inflammatory JJ cord-010092-uftc8inx 11643 2 cytokine cytokine NN cord-010092-uftc8inx 11643 3 / / SYM cord-010092-uftc8inx 11643 4 chemokine chemokine NN cord-010092-uftc8inx 11643 5 production production NN cord-010092-uftc8inx 11643 6 was be VBD cord-010092-uftc8inx 11643 7 determined determine VBN cord-010092-uftc8inx 11643 8 using use VBG cord-010092-uftc8inx 11643 9 sheep sheep NNS cord-010092-uftc8inx 11643 10 specific specific JJ cord-010092-uftc8inx 11643 11 in in IN cord-010092-uftc8inx 11643 12 - - HYPH cord-010092-uftc8inx 11643 13 house house NN cord-010092-uftc8inx 11643 14 ELISA ELISA NNP cord-010092-uftc8inx 11643 15 ( ( -LRB- cord-010092-uftc8inx 11643 16 IL-1b IL-1b NNP cord-010092-uftc8inx 11643 17 , , , cord-010092-uftc8inx 11643 18 IL-6 IL-6 NNP cord-010092-uftc8inx 11643 19 , , , cord-010092-uftc8inx 11643 20 IL-8 IL-8 NNP cord-010092-uftc8inx 11643 21 and and CC cord-010092-uftc8inx 11643 22 IL-10 IL-10 NNP cord-010092-uftc8inx 11643 23 ) ) -RRB- cord-010092-uftc8inx 11643 24 . . . cord-010092-uftc8inx 11644 1 Twoway twoway JJ cord-010092-uftc8inx 11644 2 analysis analysis NN cord-010092-uftc8inx 11644 3 of of IN cord-010092-uftc8inx 11644 4 variance variance NN cord-010092-uftc8inx 11644 5 with with IN cord-010092-uftc8inx 11644 6 Bonferroni Bonferroni NNP cord-010092-uftc8inx 11644 7 's 's POS cord-010092-uftc8inx 11644 8 post post JJ cord-010092-uftc8inx 11644 9 - - JJ cord-010092-uftc8inx 11644 10 test test NN cord-010092-uftc8inx 11644 11 was be VBD cord-010092-uftc8inx 11644 12 used use VBN cord-010092-uftc8inx 11644 13 to to TO cord-010092-uftc8inx 11644 14 measure measure VB cord-010092-uftc8inx 11644 15 the the DT cord-010092-uftc8inx 11644 16 effect effect NN cord-010092-uftc8inx 11644 17 of of IN cord-010092-uftc8inx 11644 18 incubation incubation NN cord-010092-uftc8inx 11644 19 time time NN cord-010092-uftc8inx 11644 20 and and CC cord-010092-uftc8inx 11644 21 concentration concentration NN cord-010092-uftc8inx 11644 22 compared compare VBN cord-010092-uftc8inx 11644 23 to to IN cord-010092-uftc8inx 11644 24 no no DT cord-010092-uftc8inx 11644 25 LPS LPS NNP cord-010092-uftc8inx 11644 26 matched match VBD cord-010092-uftc8inx 11644 27 samples sample NNS cord-010092-uftc8inx 11644 28 . . . cord-010092-uftc8inx 11645 1 Results result NNS cord-010092-uftc8inx 11645 2 : : : cord-010092-uftc8inx 11646 1 When when WRB cord-010092-uftc8inx 11646 2 EDTA EDTA NNP cord-010092-uftc8inx 11646 3 was be VBD cord-010092-uftc8inx 11646 4 used use VBN cord-010092-uftc8inx 11646 5 as as IN cord-010092-uftc8inx 11646 6 an an DT cord-010092-uftc8inx 11646 7 anticoagulant anticoagulant NN cord-010092-uftc8inx 11646 8 , , , cord-010092-uftc8inx 11646 9 addition addition NN cord-010092-uftc8inx 11646 10 of of IN cord-010092-uftc8inx 11646 11 LPS LPS NNP cord-010092-uftc8inx 11646 12 resulted result VBD cord-010092-uftc8inx 11646 13 in in IN cord-010092-uftc8inx 11646 14 production production NN cord-010092-uftc8inx 11646 15 of of IN cord-010092-uftc8inx 11646 16 sheep sheep NN cord-010092-uftc8inx 11646 17 IL-1b IL-1b NNS cord-010092-uftc8inx 11646 18 and and CC cord-010092-uftc8inx 11647 1 IL-10 IL-10 NNP cord-010092-uftc8inx 11647 2 but but CC cord-010092-uftc8inx 11647 3 not not RB cord-010092-uftc8inx 11647 4 IL-6 IL-6 NNP cord-010092-uftc8inx 11647 5 or or CC cord-010092-uftc8inx 11647 6 IL-8 IL-8 NNP cord-010092-uftc8inx 11647 7 . . . cord-010092-uftc8inx 11648 1 IL-1b IL-1b NNP cord-010092-uftc8inx 11648 2 production production NN cord-010092-uftc8inx 11648 3 was be VBD cord-010092-uftc8inx 11648 4 significantly significantly RB cord-010092-uftc8inx 11648 5 increased increase VBN cord-010092-uftc8inx 11648 6 following follow VBG cord-010092-uftc8inx 11648 7 stimulation stimulation NN cord-010092-uftc8inx 11648 8 of of IN cord-010092-uftc8inx 11648 9 100 100 CD cord-010092-uftc8inx 11648 10 lg lg NN cord-010092-uftc8inx 11648 11 / / SYM cord-010092-uftc8inx 11648 12 mL mL NNP cord-010092-uftc8inx 11648 13 LPS LPS NNP cord-010092-uftc8inx 11648 14 for for IN cord-010092-uftc8inx 11648 15 6 6 CD cord-010092-uftc8inx 11648 16 h h NN cord-010092-uftc8inx 11648 17 ( ( -LRB- cord-010092-uftc8inx 11648 18 P p NN cord-010092-uftc8inx 11648 19 = = SYM cord-010092-uftc8inx 11648 20 0.043 0.043 CD cord-010092-uftc8inx 11648 21 ) ) -RRB- cord-010092-uftc8inx 11648 22 and and CC cord-010092-uftc8inx 11648 23 declined decline VBD cord-010092-uftc8inx 11648 24 following follow VBG cord-010092-uftc8inx 11648 25 36 36 CD cord-010092-uftc8inx 11648 26 h h NN cord-010092-uftc8inx 11648 27 incubation incubation NN cord-010092-uftc8inx 11648 28 . . . cord-010092-uftc8inx 11649 1 Release release NN cord-010092-uftc8inx 11649 2 of of IN cord-010092-uftc8inx 11649 3 IL-10 IL-10 NNP cord-010092-uftc8inx 11649 4 was be VBD cord-010092-uftc8inx 11649 5 significant significant JJ cord-010092-uftc8inx 11649 6 12 12 CD cord-010092-uftc8inx 11649 7 h h NN cord-010092-uftc8inx 11649 8 post post NN cord-010092-uftc8inx 11649 9 - - JJ cord-010092-uftc8inx 11649 10 LPS lps JJ cord-010092-uftc8inx 11649 11 stimulation stimulation NN cord-010092-uftc8inx 11649 12 with with IN cord-010092-uftc8inx 11649 13 100 100 CD cord-010092-uftc8inx 11649 14 lg lg NN cord-010092-uftc8inx 11649 15 / / SYM cord-010092-uftc8inx 11649 16 mL ml NN cord-010092-uftc8inx 11649 17 ( ( -LRB- cord-010092-uftc8inx 11649 18 P p NN cord-010092-uftc8inx 11649 19 = = SYM cord-010092-uftc8inx 11649 20 0.030 0.030 CD cord-010092-uftc8inx 11649 21 ) ) -RRB- cord-010092-uftc8inx 11649 22 and and CC cord-010092-uftc8inx 11649 23 reached reach VBD cord-010092-uftc8inx 11649 24 a a DT cord-010092-uftc8inx 11649 25 maximum maximum NN cord-010092-uftc8inx 11649 26 at at IN cord-010092-uftc8inx 11649 27 24 24 CD cord-010092-uftc8inx 11649 28 h. h. NN cord-010092-uftc8inx 11650 1 The the DT cord-010092-uftc8inx 11650 2 use use NN cord-010092-uftc8inx 11650 3 of of IN cord-010092-uftc8inx 11650 4 heparinized heparinized JJ cord-010092-uftc8inx 11650 5 blood blood NN cord-010092-uftc8inx 11650 6 resulted result VBD cord-010092-uftc8inx 11650 7 in in IN cord-010092-uftc8inx 11650 8 a a DT cord-010092-uftc8inx 11650 9 different different JJ cord-010092-uftc8inx 11650 10 immune immune NN cord-010092-uftc8inx 11650 11 profile profile NN cord-010092-uftc8inx 11650 12 as as IN cord-010092-uftc8inx 11650 13 all all DT cord-010092-uftc8inx 11650 14 inflammatory inflammatory JJ cord-010092-uftc8inx 11650 15 markers marker NNS cord-010092-uftc8inx 11650 16 tested test VBN cord-010092-uftc8inx 11650 17 were be VBD cord-010092-uftc8inx 11650 18 detected detect VBN cord-010092-uftc8inx 11650 19 following follow VBG cord-010092-uftc8inx 11650 20 stimulation stimulation NN cord-010092-uftc8inx 11650 21 with with IN cord-010092-uftc8inx 11650 22 much much JJ cord-010092-uftc8inx 11650 23 lower low JJR cord-010092-uftc8inx 11650 24 concentrations concentration NNS cord-010092-uftc8inx 11650 25 of of IN cord-010092-uftc8inx 11650 26 LPS LPS NNP cord-010092-uftc8inx 11650 27 ( ( -LRB- cord-010092-uftc8inx 11650 28 1 1 CD cord-010092-uftc8inx 11650 29 lg lg NNP cord-010092-uftc8inx 11650 30 / / SYM cord-010092-uftc8inx 11650 31 mL mL NNP cord-010092-uftc8inx 11650 32 ) ) -RRB- cord-010092-uftc8inx 11650 33 , , , cord-010092-uftc8inx 11650 34 although although IN cord-010092-uftc8inx 11650 35 the the DT cord-010092-uftc8inx 11650 36 incubation incubation NN cord-010092-uftc8inx 11650 37 times time NNS cord-010092-uftc8inx 11650 38 differed differ VBD cord-010092-uftc8inx 11650 39 . . . cord-010092-uftc8inx 11651 1 IL-1b IL-1b NNP cord-010092-uftc8inx 11651 2 was be VBD cord-010092-uftc8inx 11651 3 significantly significantly RB cord-010092-uftc8inx 11651 4 increased increase VBN cord-010092-uftc8inx 11651 5 following follow VBG cord-010092-uftc8inx 11651 6 2 2 CD cord-010092-uftc8inx 11651 7 h h NN cord-010092-uftc8inx 11651 8 incubation incubation NN cord-010092-uftc8inx 11651 9 ( ( -LRB- cord-010092-uftc8inx 11651 10 P p NN cord-010092-uftc8inx 11651 11 = = SYM cord-010092-uftc8inx 11651 12 0.002 0.002 CD cord-010092-uftc8inx 11651 13 ) ) -RRB- cord-010092-uftc8inx 11651 14 , , , cord-010092-uftc8inx 11651 15 with with IN cord-010092-uftc8inx 11651 16 increasing increase VBG cord-010092-uftc8inx 11651 17 levels level NNS cord-010092-uftc8inx 11651 18 observed observe VBD cord-010092-uftc8inx 11651 19 up up IN cord-010092-uftc8inx 11651 20 to to IN cord-010092-uftc8inx 11651 21 24 24 CD cord-010092-uftc8inx 11651 22 h h NN cord-010092-uftc8inx 11651 23 post post JJ cord-010092-uftc8inx 11651 24 - - JJ cord-010092-uftc8inx 11651 25 LPS lps JJ cord-010092-uftc8inx 11651 26 stimulation stimulation NN cord-010092-uftc8inx 11651 27 . . . cord-010092-uftc8inx 11652 1 IL-8 IL-8 NNP cord-010092-uftc8inx 11652 2 production production NN cord-010092-uftc8inx 11652 3 was be VBD cord-010092-uftc8inx 11652 4 evident evident JJ cord-010092-uftc8inx 11652 5 from from IN cord-010092-uftc8inx 11652 6 6 6 CD cord-010092-uftc8inx 11652 7 h h NN cord-010092-uftc8inx 11652 8 and and CC cord-010092-uftc8inx 11652 9 reached reach VBD cord-010092-uftc8inx 11652 10 significance significance NN cord-010092-uftc8inx 11652 11 at at IN cord-010092-uftc8inx 11652 12 24 24 CD cord-010092-uftc8inx 11652 13 h h NN cord-010092-uftc8inx 11652 14 post post JJ cord-010092-uftc8inx 11652 15 - - JJ cord-010092-uftc8inx 11652 16 LPS lps JJ cord-010092-uftc8inx 11652 17 stimulation stimulation NN cord-010092-uftc8inx 11652 18 ( ( -LRB- cord-010092-uftc8inx 11652 19 P p NN cord-010092-uftc8inx 11652 20 = = SYM cord-010092-uftc8inx 11652 21 0.009 0.009 CD cord-010092-uftc8inx 11652 22 ) ) -RRB- cord-010092-uftc8inx 11652 23 . . . cord-010092-uftc8inx 11653 1 IL-10 IL-10 NNP cord-010092-uftc8inx 11653 2 was be VBD cord-010092-uftc8inx 11653 3 significantly significantly RB cord-010092-uftc8inx 11653 4 increased increase VBN cord-010092-uftc8inx 11653 5 following follow VBG cord-010092-uftc8inx 11653 6 stimulation stimulation NN cord-010092-uftc8inx 11653 7 of of IN cord-010092-uftc8inx 11653 8 5 5 CD cord-010092-uftc8inx 11653 9 lg lg NNP cord-010092-uftc8inx 11653 10 / / SYM cord-010092-uftc8inx 11653 11 mL mL NNP cord-010092-uftc8inx 11653 12 LPS LPS NNP cord-010092-uftc8inx 11653 13 for for IN cord-010092-uftc8inx 11653 14 6 6 CD cord-010092-uftc8inx 11653 15 hr hr NN cord-010092-uftc8inx 11653 16 ( ( -LRB- cord-010092-uftc8inx 11653 17 P p NN cord-010092-uftc8inx 11653 18 = = SYM cord-010092-uftc8inx 11653 19 0.043 0.043 CD cord-010092-uftc8inx 11653 20 ) ) -RRB- cord-010092-uftc8inx 11653 21 with with IN cord-010092-uftc8inx 11653 22 lower low JJR cord-010092-uftc8inx 11653 23 concentrations concentration NNS cord-010092-uftc8inx 11653 24 of of IN cord-010092-uftc8inx 11653 25 LPS lp NNS cord-010092-uftc8inx 11653 26 resulting result VBG cord-010092-uftc8inx 11653 27 in in IN cord-010092-uftc8inx 11653 28 IL-10 IL-10 NNP cord-010092-uftc8inx 11653 29 production production NN cord-010092-uftc8inx 11653 30 at at IN cord-010092-uftc8inx 11653 31 24 24 CD cord-010092-uftc8inx 11653 32 h h NN cord-010092-uftc8inx 11653 33 ( ( -LRB- cord-010092-uftc8inx 11653 34 P p NN cord-010092-uftc8inx 11653 35 = = SYM cord-010092-uftc8inx 11653 36 0.008 0.008 CD cord-010092-uftc8inx 11653 37 ) ) -RRB- cord-010092-uftc8inx 11653 38 . . . cord-010092-uftc8inx 11654 1 Release Release NNP cord-010092-uftc8inx 11654 2 of of IN cord-010092-uftc8inx 11654 3 IL-6 IL-6 NNP cord-010092-uftc8inx 11654 4 was be VBD cord-010092-uftc8inx 11654 5 significant significant JJ cord-010092-uftc8inx 11654 6 after after IN cord-010092-uftc8inx 11654 7 6 6 CD cord-010092-uftc8inx 11654 8 h h NN cord-010092-uftc8inx 11654 9 of of IN cord-010092-uftc8inx 11654 10 50 50 CD cord-010092-uftc8inx 11654 11 lg lg NNP cord-010092-uftc8inx 11654 12 / / SYM cord-010092-uftc8inx 11654 13 mL ml NN cord-010092-uftc8inx 11654 14 LPS LPS NNP cord-010092-uftc8inx 11654 15 stimulation stimulation NN cord-010092-uftc8inx 11654 16 ( ( -LRB- cord-010092-uftc8inx 11654 17 P p NN cord-010092-uftc8inx 11654 18 = = SYM cord-010092-uftc8inx 11654 19 0.046 0.046 CD cord-010092-uftc8inx 11654 20 ) ) -RRB- cord-010092-uftc8inx 11654 21 , , , cord-010092-uftc8inx 11654 22 with with IN cord-010092-uftc8inx 11654 23 lower low JJR cord-010092-uftc8inx 11654 24 concentrations concentration NNS cord-010092-uftc8inx 11654 25 of of IN cord-010092-uftc8inx 11654 26 LPS lp NNS cord-010092-uftc8inx 11654 27 resulting result VBG cord-010092-uftc8inx 11654 28 in in IN cord-010092-uftc8inx 11654 29 IL-6 IL-6 NNP cord-010092-uftc8inx 11654 30 production production NN cord-010092-uftc8inx 11654 31 at at IN cord-010092-uftc8inx 11654 32 24 24 CD cord-010092-uftc8inx 11654 33 h h NN cord-010092-uftc8inx 11654 34 ( ( -LRB- cord-010092-uftc8inx 11654 35 P p NN cord-010092-uftc8inx 11654 36 = = SYM cord-010092-uftc8inx 11654 37 0.015 0.015 CD cord-010092-uftc8inx 11654 38 ) ) -RRB- cord-010092-uftc8inx 11654 39 . . . cord-010092-uftc8inx 11655 1 In in IN cord-010092-uftc8inx 11655 2 heparinized heparinized JJ cord-010092-uftc8inx 11655 3 whole whole JJ cord-010092-uftc8inx 11655 4 blood blood NN cord-010092-uftc8inx 11655 5 an an DT cord-010092-uftc8inx 11655 6 LPS LPS NNP cord-010092-uftc8inx 11655 7 concentration concentration NN cord-010092-uftc8inx 11655 8 - - HYPH cord-010092-uftc8inx 11655 9 dependent dependent JJ cord-010092-uftc8inx 11655 10 effect effect NN cord-010092-uftc8inx 11655 11 was be VBD cord-010092-uftc8inx 11655 12 evident evident JJ cord-010092-uftc8inx 11655 13 for for IN cord-010092-uftc8inx 11655 14 all all DT cord-010092-uftc8inx 11655 15 cytokines cytokine NNS cord-010092-uftc8inx 11655 16 . . . cord-010092-uftc8inx 11656 1 Summary Summary NNP cord-010092-uftc8inx 11656 2 / / SYM cord-010092-uftc8inx 11656 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 11656 4 : : : cord-010092-uftc8inx 11657 1 Using use VBG cord-010092-uftc8inx 11657 2 a a DT cord-010092-uftc8inx 11657 3 time time NN cord-010092-uftc8inx 11657 4 - - HYPH cord-010092-uftc8inx 11657 5 and and CC cord-010092-uftc8inx 11657 6 concentration concentration NN cord-010092-uftc8inx 11657 7 - - HYPH cord-010092-uftc8inx 11657 8 approach approach VB cord-010092-uftc8inx 11657 9 our -PRON- PRP$ cord-010092-uftc8inx 11657 10 findings finding NNS cord-010092-uftc8inx 11657 11 indicate indicate VBP cord-010092-uftc8inx 11657 12 that that IN cord-010092-uftc8inx 11657 13 sheep sheep NNS cord-010092-uftc8inx 11657 14 are be VBP cord-010092-uftc8inx 11657 15 more more RBR cord-010092-uftc8inx 11657 16 tolerant tolerant JJ cord-010092-uftc8inx 11657 17 and and CC cord-010092-uftc8inx 11657 18 have have VBP cord-010092-uftc8inx 11657 19 a a DT cord-010092-uftc8inx 11657 20 delayed delay VBN cord-010092-uftc8inx 11657 21 response response NN cord-010092-uftc8inx 11657 22 to to IN cord-010092-uftc8inx 11657 23 LPS LPS NNP cord-010092-uftc8inx 11657 24 stimulation stimulation NN cord-010092-uftc8inx 11657 25 compared compare VBN cord-010092-uftc8inx 11657 26 to to IN cord-010092-uftc8inx 11657 27 previous previous JJ cord-010092-uftc8inx 11657 28 research research NN cord-010092-uftc8inx 11657 29 using use VBG cord-010092-uftc8inx 11657 30 similar similar JJ cord-010092-uftc8inx 11657 31 human human NN cord-010092-uftc8inx 11657 32 in in IN cord-010092-uftc8inx 11657 33 vitro vitro FW cord-010092-uftc8inx 11657 34 whole whole JJ cord-010092-uftc8inx 11657 35 blood blood NN cord-010092-uftc8inx 11657 36 culture culture NN cord-010092-uftc8inx 11657 37 models model NNS cord-010092-uftc8inx 11657 38 . . . cord-010092-uftc8inx 11658 1 In in IN cord-010092-uftc8inx 11658 2 addition addition NN cord-010092-uftc8inx 11658 3 , , , cord-010092-uftc8inx 11658 4 data datum NNS cord-010092-uftc8inx 11658 5 suggest suggest VBP cord-010092-uftc8inx 11658 6 that that IN cord-010092-uftc8inx 11658 7 sheep sheep NNS cord-010092-uftc8inx 11658 8 have have VBP cord-010092-uftc8inx 11658 9 greater great JJR cord-010092-uftc8inx 11658 10 immune immune JJ cord-010092-uftc8inx 11658 11 responses response NNS cord-010092-uftc8inx 11658 12 using use VBG cord-010092-uftc8inx 11658 13 heparin heparin NN cord-010092-uftc8inx 11658 14 as as IN cord-010092-uftc8inx 11658 15 anticoagulant anticoagulant NN cord-010092-uftc8inx 11658 16 for for IN cord-010092-uftc8inx 11658 17 the the DT cord-010092-uftc8inx 11658 18 collection collection NN cord-010092-uftc8inx 11658 19 of of IN cord-010092-uftc8inx 11658 20 blood blood NN cord-010092-uftc8inx 11658 21 samples sample NNS cord-010092-uftc8inx 11658 22 . . . cord-010092-uftc8inx 11659 1 Improving improve VBG cord-010092-uftc8inx 11659 2 our -PRON- PRP$ cord-010092-uftc8inx 11659 3 understanding understanding NN cord-010092-uftc8inx 11659 4 of of IN cord-010092-uftc8inx 11659 5 sheep sheep NNS cord-010092-uftc8inx 11659 6 immunology immunology NN cord-010092-uftc8inx 11659 7 and and CC cord-010092-uftc8inx 11659 8 development development NN cord-010092-uftc8inx 11659 9 of of IN cord-010092-uftc8inx 11659 10 relevant relevant JJ cord-010092-uftc8inx 11659 11 sheep sheep NN cord-010092-uftc8inx 11659 12 transfusion transfusion NN cord-010092-uftc8inx 11659 13 models model NNS cord-010092-uftc8inx 11659 14 will will MD cord-010092-uftc8inx 11659 15 provide provide VB cord-010092-uftc8inx 11659 16 a a DT cord-010092-uftc8inx 11659 17 bridge bridge NN cord-010092-uftc8inx 11659 18 between between IN cord-010092-uftc8inx 11659 19 sheep sheep NN cord-010092-uftc8inx 11659 20 models model NNS cord-010092-uftc8inx 11659 21 of of IN cord-010092-uftc8inx 11659 22 transfusion transfusion NN cord-010092-uftc8inx 11659 23 and and CC cord-010092-uftc8inx 11659 24 clinical clinical JJ cord-010092-uftc8inx 11659 25 settings setting NNS cord-010092-uftc8inx 11659 26 . . . cord-010092-uftc8inx 11660 1 1 1 LS cord-010092-uftc8inx 11660 2 . . . cord-010092-uftc8inx 11660 3 RhDIg RhDIg NNPS cord-010092-uftc8inx 11660 4 inappropriately inappropriately RB cord-010092-uftc8inx 11660 5 administered administer VBD cord-010092-uftc8inx 11660 6 ( ( -LRB- cord-010092-uftc8inx 11660 7 unnecessary unnecessary JJ cord-010092-uftc8inx 11660 8 exposure exposure NN cord-010092-uftc8inx 11660 9 ) ) -RRB- cord-010092-uftc8inx 11661 1 ( ( -LRB- cord-010092-uftc8inx 11661 2 n n NN cord-010092-uftc8inx 11661 3 = = SYM cord-010092-uftc8inx 11661 4 17 17 CD cord-010092-uftc8inx 11661 5 , , , cord-010092-uftc8inx 11661 6 40 40 CD cord-010092-uftc8inx 11661 7 % % NN cord-010092-uftc8inx 11661 8 ) ) -RRB- cord-010092-uftc8inx 11662 1 Administered administer VBN cord-010092-uftc8inx 11662 2 to to IN cord-010092-uftc8inx 11662 3 : : : cord-010092-uftc8inx 11662 4 -RhD -RhD NFP cord-010092-uftc8inx 11662 5 positive positive JJ cord-010092-uftc8inx 11662 6 woman woman NN cord-010092-uftc8inx 11662 7 ( ( -LRB- cord-010092-uftc8inx 11662 8 n n NN cord-010092-uftc8inx 11662 9 = = SYM cord-010092-uftc8inx 11662 10 9 9 CD cord-010092-uftc8inx 11662 11 ) ) -RRB- cord-010092-uftc8inx 11662 12 -RhD -RhD . cord-010092-uftc8inx 11662 13 negative negative JJ cord-010092-uftc8inx 11662 14 mother mother NN cord-010092-uftc8inx 11662 15 with with IN cord-010092-uftc8inx 11662 16 RhD RhD NNP cord-010092-uftc8inx 11662 17 negative negative JJ cord-010092-uftc8inx 11662 18 neonate neonate NN cord-010092-uftc8inx 11662 19 ( ( -LRB- cord-010092-uftc8inx 11662 20 n n NN cord-010092-uftc8inx 11662 21 = = SYM cord-010092-uftc8inx 11662 22 5 5 CD cord-010092-uftc8inx 11662 23 ) ) -RRB- cord-010092-uftc8inx 11663 1 -Woman -Woman NNP cord-010092-uftc8inx 11663 2 with with IN cord-010092-uftc8inx 11663 3 immune immune JJ cord-010092-uftc8inx 11663 4 anti anti AFX cord-010092-uftc8inx 11663 5 D D NNP cord-010092-uftc8inx 11663 6 ( ( -LRB- cord-010092-uftc8inx 11663 7 n n NN cord-010092-uftc8inx 11663 8 = = SYM cord-010092-uftc8inx 11663 9 1 1 CD cord-010092-uftc8inx 11663 10 ) ) -RRB- cord-010092-uftc8inx 11664 1 -Administered -administere VBN cord-010092-uftc8inx 11665 1 in in IN cord-010092-uftc8inx 11665 2 error error NN cord-010092-uftc8inx 11665 3 ( ( -LRB- cord-010092-uftc8inx 11665 4 instead instead RB cord-010092-uftc8inx 11665 5 of of IN cord-010092-uftc8inx 11665 6 other other JJ cord-010092-uftc8inx 11665 7 Ig Ig NNP cord-010092-uftc8inx 11665 8 ) ) -RRB- cord-010092-uftc8inx 11666 1 ( ( -LRB- cord-010092-uftc8inx 11666 2 n n NN cord-010092-uftc8inx 11666 3 = = SYM cord-010092-uftc8inx 11666 4 2 2 CD cord-010092-uftc8inx 11666 5 ) ) -RRB- cord-010092-uftc8inx 11667 1 2RhDIg 2rhdig CD cord-010092-uftc8inx 11667 2 delayed delay VBN cord-010092-uftc8inx 11667 3 / / SYM cord-010092-uftc8inx 11667 4 omitted omit VBN cord-010092-uftc8inx 11667 5 / / SYM cord-010092-uftc8inx 11667 6 wrong wrong JJ cord-010092-uftc8inx 11667 7 dose dose NN cord-010092-uftc8inx 11667 8 ( ( -LRB- cord-010092-uftc8inx 11667 9 risk risk NN cord-010092-uftc8inx 11667 10 of of IN cord-010092-uftc8inx 11667 11 sensitisation sensitisation NN cord-010092-uftc8inx 11667 12 to to IN cord-010092-uftc8inx 11667 13 the the DT cord-010092-uftc8inx 11667 14 D D NNP cord-010092-uftc8inx 11667 15 antigen antigen NN cord-010092-uftc8inx 11667 16 ) ) -RRB- cord-010092-uftc8inx 11668 1 ( ( -LRB- cord-010092-uftc8inx 11668 2 n n NN cord-010092-uftc8inx 11668 3 = = SYM cord-010092-uftc8inx 11668 4 17 17 CD cord-010092-uftc8inx 11668 5 , , , cord-010092-uftc8inx 11668 6 40 40 CD cord-010092-uftc8inx 11668 7 % % NN cord-010092-uftc8inx 11668 8 ) ) -RRB- cord-010092-uftc8inx 11669 1 -Omitted -omitte VBN cord-010092-uftc8inx 11670 1 ( ( -LRB- cord-010092-uftc8inx 11670 2 n n NN cord-010092-uftc8inx 11670 3 = = SYM cord-010092-uftc8inx 11670 4 14 14 CD cord-010092-uftc8inx 11670 5 ) ) -RRB- cord-010092-uftc8inx 11671 1 -Delayed -Delayed NNP cord-010092-uftc8inx 11672 1 ( ( -LRB- cord-010092-uftc8inx 11672 2 n n NN cord-010092-uftc8inx 11672 3 = = SYM cord-010092-uftc8inx 11672 4 1 1 CD cord-010092-uftc8inx 11672 5 ) ) -RRB- cord-010092-uftc8inx 11672 6 -Inadequate -Inadequate : cord-010092-uftc8inx 11672 7 dose dose NN cord-010092-uftc8inx 11672 8 ( ( -LRB- cord-010092-uftc8inx 11672 9 n n NN cord-010092-uftc8inx 11672 10 = = SYM cord-010092-uftc8inx 11672 11 2 2 CD cord-010092-uftc8inx 11672 12 ) ) -RRB- cord-010092-uftc8inx 11672 13 3Administration 3administration CD cord-010092-uftc8inx 11672 14 without without IN cord-010092-uftc8inx 11673 1 correct correct JJ cord-010092-uftc8inx 11673 2 patient patient JJ cord-010092-uftc8inx 11673 3 identification identification NN cord-010092-uftc8inx 11673 4 ( ( -LRB- cord-010092-uftc8inx 11673 5 n n NN cord-010092-uftc8inx 11673 6 = = SYM cord-010092-uftc8inx 11673 7 6 6 CD cord-010092-uftc8inx 11673 8 , , , cord-010092-uftc8inx 11673 9 14 14 CD cord-010092-uftc8inx 11673 10 % % NN cord-010092-uftc8inx 11673 11 ) ) -RRB- cord-010092-uftc8inx 11673 12 4Storage 4Storage NNS cord-010092-uftc8inx 11673 13 & & CC cord-010092-uftc8inx 11673 14 handling handling NN cord-010092-uftc8inx 11674 1 ( ( -LRB- cord-010092-uftc8inx 11674 2 n n NN cord-010092-uftc8inx 11674 3 = = SYM cord-010092-uftc8inx 11674 4 3 3 CD cord-010092-uftc8inx 11674 5 , , , cord-010092-uftc8inx 11674 6 7 7 CD cord-010092-uftc8inx 11674 7 % % NN cord-010092-uftc8inx 11674 8 ) ) -RRB- cord-010092-uftc8inx 11674 9 Failure failure NN cord-010092-uftc8inx 11674 10 to to TO cord-010092-uftc8inx 11674 11 check check VB cord-010092-uftc8inx 11674 12 the the DT cord-010092-uftc8inx 11674 13 maternal maternal JJ cord-010092-uftc8inx 11674 14 and and CC cord-010092-uftc8inx 11674 15 neonatal neonatal JJ cord-010092-uftc8inx 11674 16 blood blood NN cord-010092-uftc8inx 11674 17 groups group NNS cord-010092-uftc8inx 11674 18 prior prior RB cord-010092-uftc8inx 11674 19 to to IN cord-010092-uftc8inx 11674 20 administration administration NN cord-010092-uftc8inx 11674 21 was be VBD cord-010092-uftc8inx 11674 22 identified identify VBN cord-010092-uftc8inx 11674 23 as as IN cord-010092-uftc8inx 11674 24 a a DT cord-010092-uftc8inx 11674 25 source source NN cord-010092-uftc8inx 11674 26 of of IN cord-010092-uftc8inx 11674 27 error error NN cord-010092-uftc8inx 11674 28 . . . cord-010092-uftc8inx 11675 1 Misinterpretation misinterpretation NN cord-010092-uftc8inx 11675 2 of of IN cord-010092-uftc8inx 11675 3 blood blood NN cord-010092-uftc8inx 11675 4 results result NNS cord-010092-uftc8inx 11675 5 also also RB cord-010092-uftc8inx 11675 6 led lead VBD cord-010092-uftc8inx 11675 7 to to IN cord-010092-uftc8inx 11675 8 women woman NNS cord-010092-uftc8inx 11675 9 receiving receive VBG cord-010092-uftc8inx 11675 10 product product NN cord-010092-uftc8inx 11675 11 inappropriately inappropriately RB cord-010092-uftc8inx 11675 12 . . . cord-010092-uftc8inx 11676 1 e.g. e.g. RB cord-010092-uftc8inx 11676 2 reading read VBG cord-010092-uftc8inx 11676 3 a a DT cord-010092-uftc8inx 11676 4 negative negative JJ cord-010092-uftc8inx 11676 5 antibody antibody NN cord-010092-uftc8inx 11676 6 screen screen NN cord-010092-uftc8inx 11676 7 as as IN cord-010092-uftc8inx 11676 8 the the DT cord-010092-uftc8inx 11676 9 mother mother NN cord-010092-uftc8inx 11676 10 being be VBG cord-010092-uftc8inx 11676 11 RhD RhD NNP cord-010092-uftc8inx 11676 12 negative negative JJ cord-010092-uftc8inx 11676 13 . . . cord-010092-uftc8inx 11677 1 Patient patient JJ cord-010092-uftc8inx 11677 2 identification identification NN cord-010092-uftc8inx 11677 3 was be VBD cord-010092-uftc8inx 11677 4 raised raise VBN cord-010092-uftc8inx 11677 5 as as IN cord-010092-uftc8inx 11677 6 an an DT cord-010092-uftc8inx 11677 7 issue issue NN cord-010092-uftc8inx 11677 8 . . . cord-010092-uftc8inx 11678 1 RhDIg RhDIg NNS cord-010092-uftc8inx 11678 2 is be VBZ cord-010092-uftc8inx 11678 3 often often RB cord-010092-uftc8inx 11678 4 stored store VBN cord-010092-uftc8inx 11678 5 in in IN cord-010092-uftc8inx 11678 6 satellite satellite NN cord-010092-uftc8inx 11678 7 blood blood NN cord-010092-uftc8inx 11678 8 fridges fridge NNS cord-010092-uftc8inx 11678 9 for for IN cord-010092-uftc8inx 11678 10 easy easy JJ cord-010092-uftc8inx 11678 11 access access NN cord-010092-uftc8inx 11678 12 . . . cord-010092-uftc8inx 11679 1 Collection collection NN cord-010092-uftc8inx 11679 2 from from IN cord-010092-uftc8inx 11679 3 these these DT cord-010092-uftc8inx 11679 4 areas area NNS cord-010092-uftc8inx 11679 5 did do VBD cord-010092-uftc8inx 11679 6 not not RB cord-010092-uftc8inx 11679 7 always always RB cord-010092-uftc8inx 11679 8 require require VB cord-010092-uftc8inx 11679 9 confirmation confirmation NN cord-010092-uftc8inx 11679 10 against against IN cord-010092-uftc8inx 11679 11 patient patient JJ cord-010092-uftc8inx 11679 12 identifiers identifier NNS cord-010092-uftc8inx 11679 13 and and CC cord-010092-uftc8inx 11679 14 there there EX cord-010092-uftc8inx 11679 15 was be VBD cord-010092-uftc8inx 11679 16 no no DT cord-010092-uftc8inx 11679 17 register register NN cord-010092-uftc8inx 11679 18 of of IN cord-010092-uftc8inx 11679 19 women woman NNS cord-010092-uftc8inx 11679 20 who who WP cord-010092-uftc8inx 11679 21 received receive VBD cord-010092-uftc8inx 11679 22 product product NN cord-010092-uftc8inx 11679 23 or or CC cord-010092-uftc8inx 11679 24 link link NN cord-010092-uftc8inx 11679 25 to to IN cord-010092-uftc8inx 11679 26 the the DT cord-010092-uftc8inx 11679 27 batch batch NN cord-010092-uftc8inx 11679 28 number number NN cord-010092-uftc8inx 11679 29 to to TO cord-010092-uftc8inx 11679 30 ensure ensure VB cord-010092-uftc8inx 11679 31 traceability traceability NN cord-010092-uftc8inx 11679 32 . . . cord-010092-uftc8inx 11680 1 Two two CD cord-010092-uftc8inx 11680 2 incidents incident NNS cord-010092-uftc8inx 11680 3 involved involve VBD cord-010092-uftc8inx 11680 4 the the DT cord-010092-uftc8inx 11680 5 administration administration NN cord-010092-uftc8inx 11680 6 of of IN cord-010092-uftc8inx 11680 7 RhDIg RhDIg NNS cord-010092-uftc8inx 11680 8 when when WRB cord-010092-uftc8inx 11680 9 the the DT cord-010092-uftc8inx 11680 10 prescription prescription NN cord-010092-uftc8inx 11680 11 for for IN cord-010092-uftc8inx 11680 12 other other JJ cord-010092-uftc8inx 11680 13 immunoglobulin immunoglobulin NN cord-010092-uftc8inx 11680 14 products product NNS cord-010092-uftc8inx 11680 15 was be VBD cord-010092-uftc8inx 11680 16 not not RB cord-010092-uftc8inx 11680 17 clear clear JJ cord-010092-uftc8inx 11680 18 , , , cord-010092-uftc8inx 11680 19 leading lead VBG cord-010092-uftc8inx 11680 20 to to IN cord-010092-uftc8inx 11680 21 a a DT cord-010092-uftc8inx 11680 22 child child NN cord-010092-uftc8inx 11680 23 and and CC cord-010092-uftc8inx 11680 24 a a DT cord-010092-uftc8inx 11680 25 baby baby NN cord-010092-uftc8inx 11680 26 receiving receive VBG cord-010092-uftc8inx 11680 27 RhDIg RhDIg NNS cord-010092-uftc8inx 11680 28 instead instead RB cord-010092-uftc8inx 11680 29 of of IN cord-010092-uftc8inx 11680 30 the the DT cord-010092-uftc8inx 11680 31 intended intended JJ cord-010092-uftc8inx 11680 32 immunoglobulin immunoglobulin NN cord-010092-uftc8inx 11680 33 . . . cord-010092-uftc8inx 11681 1 Summary Summary NNP cord-010092-uftc8inx 11681 2 / / SYM cord-010092-uftc8inx 11681 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 11681 4 : : : cord-010092-uftc8inx 11682 1 These these DT cord-010092-uftc8inx 11682 2 incidents incident NNS cord-010092-uftc8inx 11682 3 indicate indicate VBP cord-010092-uftc8inx 11682 4 problems problem NNS cord-010092-uftc8inx 11682 5 with with IN cord-010092-uftc8inx 11682 6 the the DT cord-010092-uftc8inx 11682 7 processes process NNS cord-010092-uftc8inx 11682 8 of of IN cord-010092-uftc8inx 11682 9 appropriate appropriate JJ cord-010092-uftc8inx 11682 10 identification identification NN cord-010092-uftc8inx 11682 11 of of IN cord-010092-uftc8inx 11682 12 women woman NNS cord-010092-uftc8inx 11682 13 who who WP cord-010092-uftc8inx 11682 14 need need VBP cord-010092-uftc8inx 11682 15 RhDIg RhDIg NNS cord-010092-uftc8inx 11682 16 , , , cord-010092-uftc8inx 11682 17 the the DT cord-010092-uftc8inx 11682 18 use use NN cord-010092-uftc8inx 11682 19 and and CC cord-010092-uftc8inx 11682 20 interpretation interpretation NN cord-010092-uftc8inx 11682 21 of of IN cord-010092-uftc8inx 11682 22 pathology pathology NN cord-010092-uftc8inx 11682 23 tests test NNS cord-010092-uftc8inx 11682 24 and and CC cord-010092-uftc8inx 11682 25 requirements requirement NNS cord-010092-uftc8inx 11682 26 for for IN cord-010092-uftc8inx 11682 27 prescription prescription NN cord-010092-uftc8inx 11682 28 and and CC cord-010092-uftc8inx 11682 29 administration administration NN cord-010092-uftc8inx 11682 30 . . . cord-010092-uftc8inx 11683 1 These these DT cord-010092-uftc8inx 11683 2 resulted result VBD cord-010092-uftc8inx 11683 3 in in IN cord-010092-uftc8inx 11683 4 omitted omitted JJ cord-010092-uftc8inx 11683 5 and and CC cord-010092-uftc8inx 11683 6 inappropriate inappropriate JJ cord-010092-uftc8inx 11683 7 doses dose NNS cord-010092-uftc8inx 11683 8 of of IN cord-010092-uftc8inx 11683 9 RhDIg RhDIg NNS cord-010092-uftc8inx 11683 10 . . . cord-010092-uftc8inx 11684 1 Blood blood NN cord-010092-uftc8inx 11684 2 Matters matter NNS cord-010092-uftc8inx 11684 3 has have VBZ cord-010092-uftc8inx 11684 4 made make VBN cord-010092-uftc8inx 11684 5 a a DT cord-010092-uftc8inx 11684 6 number number NN cord-010092-uftc8inx 11684 7 of of IN cord-010092-uftc8inx 11684 8 recommendations recommendation NNS cord-010092-uftc8inx 11684 9 regarding regard VBG cord-010092-uftc8inx 11684 10 RhDIg RhDIg NNP cord-010092-uftc8inx 11684 11 administration administration NN cord-010092-uftc8inx 11684 12 : : : cord-010092-uftc8inx 11684 13 -All -All : cord-010092-uftc8inx 11684 14 health health NN cord-010092-uftc8inx 11684 15 professionals professional NNS cord-010092-uftc8inx 11684 16 involved involve VBN cord-010092-uftc8inx 11684 17 in in IN cord-010092-uftc8inx 11684 18 RhDIg RhDIg NNP cord-010092-uftc8inx 11684 19 administration administration NN cord-010092-uftc8inx 11684 20 should should MD cord-010092-uftc8inx 11684 21 be be VB cord-010092-uftc8inx 11684 22 appropriately appropriately RB cord-010092-uftc8inx 11684 23 trained train VBN cord-010092-uftc8inx 11684 24 in in IN cord-010092-uftc8inx 11684 25 the the DT cord-010092-uftc8inx 11684 26 use use NN cord-010092-uftc8inx 11684 27 of of IN cord-010092-uftc8inx 11684 28 RhDIg RhDIg NNS cord-010092-uftc8inx 11684 29 -Confirmation -confirmation NN cord-010092-uftc8inx 11684 30 of of IN cord-010092-uftc8inx 11684 31 the the DT cord-010092-uftc8inx 11684 32 maternal maternal JJ cord-010092-uftc8inx 11684 33 RhD rhd NN cord-010092-uftc8inx 11684 34 status status NN cord-010092-uftc8inx 11684 35 is be VBZ cord-010092-uftc8inx 11684 36 essential essential JJ cord-010092-uftc8inx 11684 37 prior prior RB cord-010092-uftc8inx 11684 38 to to IN cord-010092-uftc8inx 11684 39 prescription prescription NN cord-010092-uftc8inx 11684 40 or or CC cord-010092-uftc8inx 11684 41 administration administration NN cord-010092-uftc8inx 11684 42 -Positive -Positive NNP cord-010092-uftc8inx 11684 43 patient patient JJ cord-010092-uftc8inx 11684 44 identification identification NN cord-010092-uftc8inx 11684 45 must must MD cord-010092-uftc8inx 11684 46 be be VB cord-010092-uftc8inx 11684 47 used use VBN cord-010092-uftc8inx 11684 48 prior prior RB cord-010092-uftc8inx 11684 49 to to IN cord-010092-uftc8inx 11684 50 administration administration NN cord-010092-uftc8inx 11684 51 of of IN cord-010092-uftc8inx 11684 52 RhDIg RhDIg NNPS cord-010092-uftc8inx 11685 1 -Health -Health NNP cord-010092-uftc8inx 11685 2 services service NNS cord-010092-uftc8inx 11685 3 should should MD cord-010092-uftc8inx 11685 4 consider consider VB cord-010092-uftc8inx 11685 5 regular regular JJ cord-010092-uftc8inx 11685 6 auditing auditing NN cord-010092-uftc8inx 11685 7 to to TO cord-010092-uftc8inx 11685 8 identify identify VB cord-010092-uftc8inx 11685 9 areas area NNS cord-010092-uftc8inx 11685 10 for for IN cord-010092-uftc8inx 11685 11 improvement improvement NN cord-010092-uftc8inx 11685 12 relating relate VBG cord-010092-uftc8inx 11685 13 to to IN cord-010092-uftc8inx 11685 14 RhDIg RhDIg NNS cord-010092-uftc8inx 11685 15 Blood blood NN cord-010092-uftc8inx 11685 16 Matters Matters NNPS cord-010092-uftc8inx 11685 17 continues continue VBZ cord-010092-uftc8inx 11685 18 to to TO cord-010092-uftc8inx 11685 19 work work VB cord-010092-uftc8inx 11685 20 with with IN cord-010092-uftc8inx 11685 21 maternity maternity NN cord-010092-uftc8inx 11685 22 care care NN cord-010092-uftc8inx 11685 23 providers provider NNS cord-010092-uftc8inx 11685 24 to to TO cord-010092-uftc8inx 11685 25 improve improve VB cord-010092-uftc8inx 11685 26 practice practice NN cord-010092-uftc8inx 11685 27 . . . cord-010092-uftc8inx 11686 1 Centro Centro NNP cord-010092-uftc8inx 11686 2 Comunitario Comunitario NNP cord-010092-uftc8inx 11686 3 de de NNP cord-010092-uftc8inx 11686 4 Sangre Sangre NNP cord-010092-uftc8inx 11686 5 y y NNP cord-010092-uftc8inx 11686 6 Tejidos Tejidos NNP cord-010092-uftc8inx 11686 7 de de NNP cord-010092-uftc8inx 11686 8 Asturias Asturias NNP cord-010092-uftc8inx 11686 9 , , , cord-010092-uftc8inx 11686 10 Oviedo Oviedo NNP cord-010092-uftc8inx 11686 11 2 2 CD cord-010092-uftc8inx 11686 12 Agencia Agencia NNP cord-010092-uftc8inx 11686 13 Gallega Gallega NNP cord-010092-uftc8inx 11686 14 de de NNP cord-010092-uftc8inx 11686 15 Sangre Sangre NNP cord-010092-uftc8inx 11686 16 , , , cord-010092-uftc8inx 11686 17 Organos Organos NNP cord-010092-uftc8inx 11686 18 y y NNP cord-010092-uftc8inx 11686 19 Tejidos Tejidos NNP cord-010092-uftc8inx 11686 20 , , , cord-010092-uftc8inx 11686 21 Galicia Galicia NNP cord-010092-uftc8inx 11686 22 3 3 CD cord-010092-uftc8inx 11686 23 Banco Banco NNP cord-010092-uftc8inx 11686 24 de de NNP cord-010092-uftc8inx 11686 25 Sangre Sangre NNP cord-010092-uftc8inx 11686 26 y y NNP cord-010092-uftc8inx 11686 27 Tejidos Tejidos NNP cord-010092-uftc8inx 11686 28 de de NNP cord-010092-uftc8inx 11686 29 Cantabria Cantabria NNP cord-010092-uftc8inx 11686 30 , , , cord-010092-uftc8inx 11686 31 Cantabria Cantabria NNP cord-010092-uftc8inx 11686 32 4 4 CD cord-010092-uftc8inx 11686 33 Banco Banco NNP cord-010092-uftc8inx 11686 34 de de NNP cord-010092-uftc8inx 11686 35 Sangre Sangre NNP cord-010092-uftc8inx 11686 36 de de NNP cord-010092-uftc8inx 11686 37 La La NNP cord-010092-uftc8inx 11686 38 Rioja Rioja NNP cord-010092-uftc8inx 11686 39 , , , cord-010092-uftc8inx 11686 40 La La NNP cord-010092-uftc8inx 11686 41 Rioja Rioja NNP cord-010092-uftc8inx 11686 42 5 5 CD cord-010092-uftc8inx 11686 43 Banco Banco NNP cord-010092-uftc8inx 11686 44 de de NNP cord-010092-uftc8inx 11686 45 Sangre Sangre NNP cord-010092-uftc8inx 11686 46 y y NNP cord-010092-uftc8inx 11686 47 Tejidos Tejidos NNP cord-010092-uftc8inx 11686 48 de de NNP cord-010092-uftc8inx 11686 49 Navarra Navarra NNP cord-010092-uftc8inx 11686 50 , , , cord-010092-uftc8inx 11686 51 Navarra Navarra NNP cord-010092-uftc8inx 11686 52 6 6 CD cord-010092-uftc8inx 11686 53 Banco Banco NNP cord-010092-uftc8inx 11686 54 de de NNP cord-010092-uftc8inx 11686 55 Sangre Sangre NNP cord-010092-uftc8inx 11686 56 y y NNP cord-010092-uftc8inx 11686 57 Tejidos Tejidos NNP cord-010092-uftc8inx 11686 58 de de NNP cord-010092-uftc8inx 11686 59 Arag Arag NNP cord-010092-uftc8inx 11686 60 on on IN cord-010092-uftc8inx 11686 61 , , , cord-010092-uftc8inx 11686 62 Aragon Aragon NNP cord-010092-uftc8inx 11686 63 7 7 CD cord-010092-uftc8inx 11686 64 Fundaci Fundaci NNP cord-010092-uftc8inx 11686 65 on on IN cord-010092-uftc8inx 11686 66 de de NNP cord-010092-uftc8inx 11686 67 Hemoterapia Hemoterapia NNP cord-010092-uftc8inx 11686 68 y y NNP cord-010092-uftc8inx 11686 69 Hemodonaci Hemodonaci NNP cord-010092-uftc8inx 11686 70 on on IN cord-010092-uftc8inx 11686 71 de de NNP cord-010092-uftc8inx 11686 72 Castilla Castilla NNP cord-010092-uftc8inx 11686 73 y y NNP cord-010092-uftc8inx 11686 74 Le Le NNP cord-010092-uftc8inx 11686 75 on on RP cord-010092-uftc8inx 11686 76 , , , cord-010092-uftc8inx 11686 77 Castilla Castilla NNP cord-010092-uftc8inx 11686 78 y y NNP cord-010092-uftc8inx 11686 79 Leon Leon NNP cord-010092-uftc8inx 11686 80 8 8 CD cord-010092-uftc8inx 11686 81 Fundaci Fundaci NNP cord-010092-uftc8inx 11686 82 on on IN cord-010092-uftc8inx 11686 83 Banco Banco NNP cord-010092-uftc8inx 11686 84 de de NNP cord-010092-uftc8inx 11686 85 Sangre Sangre NNP cord-010092-uftc8inx 11686 86 y y NNP cord-010092-uftc8inx 11686 87 Tejidos Tejidos NNP cord-010092-uftc8inx 11686 88 de de NNP cord-010092-uftc8inx 11686 89 las las NNP cord-010092-uftc8inx 11686 90 Islas Islas NNP cord-010092-uftc8inx 11686 91 Baleares Baleares NNP cord-010092-uftc8inx 11686 92 , , , cord-010092-uftc8inx 11686 93 Islas Islas NNP cord-010092-uftc8inx 11686 94 Baleares Baleares NNP cord-010092-uftc8inx 11686 95 , , , cord-010092-uftc8inx 11686 96 Spain Spain NNP cord-010092-uftc8inx 11686 97 9 9 CD cord-010092-uftc8inx 11686 98 Terumo Terumo NNP cord-010092-uftc8inx 11686 99 BCT BCT NNP cord-010092-uftc8inx 11686 100 Europe Europe NNP cord-010092-uftc8inx 11686 101 NV NV NNP cord-010092-uftc8inx 11686 102 , , , cord-010092-uftc8inx 11686 103 Zaventem Zaventem NNP cord-010092-uftc8inx 11686 104 , , , cord-010092-uftc8inx 11686 105 Belgium Belgium NNP cord-010092-uftc8inx 11686 106 Background Background NNP cord-010092-uftc8inx 11686 107 : : : cord-010092-uftc8inx 11686 108 Hemovigilance Hemovigilance NNP cord-010092-uftc8inx 11686 109 , , , cord-010092-uftc8inx 11686 110 a a DT cord-010092-uftc8inx 11686 111 long long JJ cord-010092-uftc8inx 11686 112 - - HYPH cord-010092-uftc8inx 11686 113 term term NN cord-010092-uftc8inx 11686 114 monitoring monitoring NN cord-010092-uftc8inx 11686 115 process process NN cord-010092-uftc8inx 11686 116 made make VBD cord-010092-uftc8inx 11686 117 mandatory mandatory JJ cord-010092-uftc8inx 11686 118 by by IN cord-010092-uftc8inx 11686 119 national national JJ cord-010092-uftc8inx 11686 120 and and CC cord-010092-uftc8inx 11686 121 supranational supranational JJ cord-010092-uftc8inx 11686 122 regulations regulation NNS cord-010092-uftc8inx 11686 123 , , , cord-010092-uftc8inx 11686 124 begins begin VBZ cord-010092-uftc8inx 11686 125 with with IN cord-010092-uftc8inx 11686 126 a a DT cord-010092-uftc8inx 11686 127 systematic systematic JJ cord-010092-uftc8inx 11686 128 whole whole JJ cord-010092-uftc8inx 11686 129 blood blood NN cord-010092-uftc8inx 11686 130 or or CC cord-010092-uftc8inx 11686 131 blood blood NN cord-010092-uftc8inx 11686 132 component component NN cord-010092-uftc8inx 11686 133 collection collection NN cord-010092-uftc8inx 11686 134 and and CC cord-010092-uftc8inx 11686 135 ends end VBZ cord-010092-uftc8inx 11686 136 with with IN cord-010092-uftc8inx 11686 137 an an DT cord-010092-uftc8inx 11686 138 examining examine VBG cord-010092-uftc8inx 11686 139 period period NN cord-010092-uftc8inx 11686 140 after after IN cord-010092-uftc8inx 11686 141 transfusion transfusion NN cord-010092-uftc8inx 11686 142 of of IN cord-010092-uftc8inx 11686 143 blood blood NN cord-010092-uftc8inx 11686 144 components component NNS cord-010092-uftc8inx 11686 145 into into IN cord-010092-uftc8inx 11686 146 the the DT cord-010092-uftc8inx 11686 147 patients patient NNS cord-010092-uftc8inx 11686 148 . . . cord-010092-uftc8inx 11687 1 In in IN cord-010092-uftc8inx 11687 2 Spain Spain NNP cord-010092-uftc8inx 11687 3 , , , cord-010092-uftc8inx 11687 4 organized organize VBN cord-010092-uftc8inx 11687 5 in in IN cord-010092-uftc8inx 11687 6 17 17 CD cord-010092-uftc8inx 11687 7 autonomous autonomous JJ cord-010092-uftc8inx 11687 8 regions region NNS cord-010092-uftc8inx 11687 9 , , , cord-010092-uftc8inx 11687 10 the the DT cord-010092-uftc8inx 11687 11 hemovigilance hemovigilance NN cord-010092-uftc8inx 11687 12 system system NN cord-010092-uftc8inx 11687 13 is be VBZ cord-010092-uftc8inx 11687 14 structured structure VBN cord-010092-uftc8inx 11687 15 in in IN cord-010092-uftc8inx 11687 16 three three CD cord-010092-uftc8inx 11687 17 levels level NNS cord-010092-uftc8inx 11687 18 : : : cord-010092-uftc8inx 11687 19 ( ( -LRB- cord-010092-uftc8inx 11687 20 1 1 LS cord-010092-uftc8inx 11687 21 ) ) -RRB- cord-010092-uftc8inx 11687 22 the the DT cord-010092-uftc8inx 11687 23 local local JJ cord-010092-uftc8inx 11687 24 level level NN cord-010092-uftc8inx 11687 25 comprised comprise VBN cord-010092-uftc8inx 11687 26 of of IN cord-010092-uftc8inx 11687 27 transfusion transfusion NN cord-010092-uftc8inx 11687 28 centers center NNS cord-010092-uftc8inx 11687 29 and and CC cord-010092-uftc8inx 11687 30 hospital hospital NN cord-010092-uftc8inx 11687 31 based base VBN cord-010092-uftc8inx 11687 32 transfusion transfusion NN cord-010092-uftc8inx 11687 33 services service NNS cord-010092-uftc8inx 11687 34 that that WDT cord-010092-uftc8inx 11687 35 monitor monitor VBP cord-010092-uftc8inx 11687 36 and and CC cord-010092-uftc8inx 11687 37 collect collect VBP cord-010092-uftc8inx 11687 38 all all DT cord-010092-uftc8inx 11687 39 transfusion transfusion NN cord-010092-uftc8inx 11687 40 related relate VBD cord-010092-uftc8inx 11687 41 adverse adverse JJ cord-010092-uftc8inx 11687 42 events event NNS cord-010092-uftc8inx 11687 43 ( ( -LRB- cord-010092-uftc8inx 11687 44 AE AE NNP cord-010092-uftc8inx 11687 45 ) ) -RRB- cord-010092-uftc8inx 11687 46 and and CC cord-010092-uftc8inx 11687 47 level level VB cord-010092-uftc8inx 11687 48 them -PRON- PRP cord-010092-uftc8inx 11687 49 up up RP cord-010092-uftc8inx 11687 50 to to IN cord-010092-uftc8inx 11687 51 ( ( -LRB- cord-010092-uftc8inx 11687 52 2 2 CD cord-010092-uftc8inx 11687 53 ) ) -RRB- cord-010092-uftc8inx 11688 1 the the DT cord-010092-uftc8inx 11688 2 regional regional JJ cord-010092-uftc8inx 11688 3 hemovigilance hemovigilance NN cord-010092-uftc8inx 11688 4 coordinator coordinator NN cord-010092-uftc8inx 11688 5 , , , cord-010092-uftc8inx 11688 6 who who WP cord-010092-uftc8inx 11688 7 communicates communicate VBZ cord-010092-uftc8inx 11688 8 all all PDT cord-010092-uftc8inx 11688 9 the the DT cord-010092-uftc8inx 11688 10 region region NN cord-010092-uftc8inx 11688 11 's 's POS cord-010092-uftc8inx 11688 12 data datum NNS cord-010092-uftc8inx 11688 13 to to IN cord-010092-uftc8inx 11688 14 the the DT cord-010092-uftc8inx 11688 15 ( ( -LRB- cord-010092-uftc8inx 11688 16 3 3 CD cord-010092-uftc8inx 11688 17 ) ) -RRB- cord-010092-uftc8inx 11688 18 Spanish Spanish NNP cord-010092-uftc8inx 11688 19 Ministry Ministry NNP cord-010092-uftc8inx 11688 20 of of IN cord-010092-uftc8inx 11688 21 health health NN cord-010092-uftc8inx 11688 22 which which WDT cord-010092-uftc8inx 11688 23 issues issue VBZ cord-010092-uftc8inx 11688 24 an an DT cord-010092-uftc8inx 11688 25 annual annual JJ cord-010092-uftc8inx 11688 26 report report NN cord-010092-uftc8inx 11688 27 and and CC cord-010092-uftc8inx 11688 28 corresponds correspond VBZ cord-010092-uftc8inx 11688 29 with with IN cord-010092-uftc8inx 11688 30 European european JJ cord-010092-uftc8inx 11688 31 institutions institution NNS cord-010092-uftc8inx 11688 32 . . . cord-010092-uftc8inx 11689 1 To to TO cord-010092-uftc8inx 11689 2 ensure ensure VB cord-010092-uftc8inx 11689 3 safer safe JJR cord-010092-uftc8inx 11689 4 blood blood NN cord-010092-uftc8inx 11689 5 supply supply NN cord-010092-uftc8inx 11689 6 , , , cord-010092-uftc8inx 11689 7 pathogen pathogen NN cord-010092-uftc8inx 11689 8 reduction reduction NN cord-010092-uftc8inx 11689 9 technology technology NN cord-010092-uftc8inx 11689 10 ( ( -LRB- cord-010092-uftc8inx 11689 11 PRT PRT NNP cord-010092-uftc8inx 11689 12 ) ) -RRB- cord-010092-uftc8inx 11689 13 was be VBD cord-010092-uftc8inx 11689 14 approved approve VBN cord-010092-uftc8inx 11689 15 and and CC cord-010092-uftc8inx 11689 16 implementation implementation NN cord-010092-uftc8inx 11689 17 started start VBD cord-010092-uftc8inx 11689 18 in in IN cord-010092-uftc8inx 11689 19 Spain Spain NNP cord-010092-uftc8inx 11689 20 in in IN cord-010092-uftc8inx 11689 21 2008 2008 CD cord-010092-uftc8inx 11689 22 . . . cord-010092-uftc8inx 11690 1 The the DT cord-010092-uftc8inx 11690 2 Mirasol Mirasol NNP cord-010092-uftc8inx 11690 3 PRT PRT NNP cord-010092-uftc8inx 11690 4 system system NN cord-010092-uftc8inx 11690 5 for for IN cord-010092-uftc8inx 11690 6 platelets platelet NNS cord-010092-uftc8inx 11690 7 and and CC cord-010092-uftc8inx 11690 8 plasma plasma NN cord-010092-uftc8inx 11690 9 was be VBD cord-010092-uftc8inx 11690 10 introduced introduce VBN cord-010092-uftc8inx 11690 11 in in IN cord-010092-uftc8inx 11690 12 2010 2010 CD cord-010092-uftc8inx 11690 13 and and CC cord-010092-uftc8inx 11690 14 is be VBZ cord-010092-uftc8inx 11690 15 currently currently RB cord-010092-uftc8inx 11690 16 being be VBG cord-010092-uftc8inx 11690 17 used use VBN cord-010092-uftc8inx 11690 18 in in IN cord-010092-uftc8inx 11690 19 10 10 CD cord-010092-uftc8inx 11690 20 of of IN cord-010092-uftc8inx 11690 21 the the DT cord-010092-uftc8inx 11690 22 17 17 CD cord-010092-uftc8inx 11690 23 Spanish spanish JJ cord-010092-uftc8inx 11690 24 regions region NNS cord-010092-uftc8inx 11690 25 . . . cord-010092-uftc8inx 11691 1 Aims aim VBZ cord-010092-uftc8inx 11691 2 : : : cord-010092-uftc8inx 11692 1 To to TO cord-010092-uftc8inx 11692 2 monitor monitor VB cord-010092-uftc8inx 11692 3 the the DT cord-010092-uftc8inx 11692 4 safety safety NN cord-010092-uftc8inx 11692 5 of of IN cord-010092-uftc8inx 11692 6 the the DT cord-010092-uftc8inx 11692 7 system system NN cord-010092-uftc8inx 11692 8 , , , cord-010092-uftc8inx 11692 9 a a DT cord-010092-uftc8inx 11692 10 passive passive JJ cord-010092-uftc8inx 11692 11 hemovigilance hemovigilance NN cord-010092-uftc8inx 11692 12 study study NN cord-010092-uftc8inx 11692 13 on on IN cord-010092-uftc8inx 11692 14 Mirasol Mirasol NNP cord-010092-uftc8inx 11692 15 treated treat VBN cord-010092-uftc8inx 11692 16 products product NNS cord-010092-uftc8inx 11692 17 was be VBD cord-010092-uftc8inx 11692 18 initiated initiate VBN cord-010092-uftc8inx 11692 19 in in IN cord-010092-uftc8inx 11692 20 the the DT cord-010092-uftc8inx 11692 21 region region NN cord-010092-uftc8inx 11692 22 of of IN cord-010092-uftc8inx 11692 23 Asturias Asturias NNP cord-010092-uftc8inx 11692 24 and and CC cord-010092-uftc8inx 11692 25 collaboration collaboration NN cord-010092-uftc8inx 11692 26 was be VBD cord-010092-uftc8inx 11692 27 extended extend VBN cord-010092-uftc8inx 11692 28 to to IN cord-010092-uftc8inx 11692 29 other other JJ cord-010092-uftc8inx 11692 30 regions region NNS cord-010092-uftc8inx 11692 31 ( ( -LRB- cord-010092-uftc8inx 11692 32 Baleares Baleares NNP cord-010092-uftc8inx 11692 33 , , , cord-010092-uftc8inx 11692 34 Galicia Galicia NNP cord-010092-uftc8inx 11692 35 , , , cord-010092-uftc8inx 11692 36 La La NNP cord-010092-uftc8inx 11692 37 Rioja Rioja NNP cord-010092-uftc8inx 11692 38 , , , cord-010092-uftc8inx 11692 39 Cantabria Cantabria NNP cord-010092-uftc8inx 11692 40 , , , cord-010092-uftc8inx 11692 41 Navarra Navarra NNP cord-010092-uftc8inx 11692 42 , , , cord-010092-uftc8inx 11692 43 Castilla Castilla NNP cord-010092-uftc8inx 11692 44 y y NNP cord-010092-uftc8inx 11692 45 Leon Leon NNP cord-010092-uftc8inx 11692 46 and and CC cord-010092-uftc8inx 11692 47 Aragon Aragon NNP cord-010092-uftc8inx 11692 48 ) ) -RRB- cord-010092-uftc8inx 11692 49 . . . cord-010092-uftc8inx 11693 1 Methods method NNS cord-010092-uftc8inx 11693 2 : : : cord-010092-uftc8inx 11693 3 Collected collect VBN cord-010092-uftc8inx 11693 4 data datum NNS cord-010092-uftc8inx 11693 5 included include VBD cord-010092-uftc8inx 11693 6 allergic allergic JJ cord-010092-uftc8inx 11693 7 and and CC cord-010092-uftc8inx 11693 8 febrile febrile JJ cord-010092-uftc8inx 11693 9 reactions reaction NNS cord-010092-uftc8inx 11693 10 , , , cord-010092-uftc8inx 11693 11 TRALI TRALI NNP cord-010092-uftc8inx 11693 12 and and CC cord-010092-uftc8inx 11693 13 all all DT cord-010092-uftc8inx 11693 14 other other JJ cord-010092-uftc8inx 11693 15 adverse adverse JJ cord-010092-uftc8inx 11693 16 event event NN cord-010092-uftc8inx 11693 17 observed observe VBD cord-010092-uftc8inx 11693 18 . . . cord-010092-uftc8inx 11694 1 Severity severity NN cord-010092-uftc8inx 11694 2 of of IN cord-010092-uftc8inx 11694 3 the the DT cord-010092-uftc8inx 11694 4 event event NN cord-010092-uftc8inx 11694 5 and and CC cord-010092-uftc8inx 11694 6 level level NN cord-010092-uftc8inx 11694 7 on on IN cord-010092-uftc8inx 11694 8 imputability imputability NN cord-010092-uftc8inx 11694 9 of of IN cord-010092-uftc8inx 11694 10 the the DT cord-010092-uftc8inx 11694 11 transfusion transfusion NN cord-010092-uftc8inx 11694 12 were be VBD cord-010092-uftc8inx 11694 13 also also RB cord-010092-uftc8inx 11694 14 assessed assess VBN cord-010092-uftc8inx 11694 15 using use VBG cord-010092-uftc8inx 11694 16 the the DT cord-010092-uftc8inx 11694 17 WHO who WP cord-010092-uftc8inx 11694 18 grading grading NN cord-010092-uftc8inx 11694 19 scale scale NN cord-010092-uftc8inx 11694 20 . . . cord-010092-uftc8inx 11695 1 Hemovigilance Hemovigilance NNP cord-010092-uftc8inx 11695 2 data datum NNS cord-010092-uftc8inx 11695 3 of of IN cord-010092-uftc8inx 11695 4 Mirasol Mirasol NNP cord-010092-uftc8inx 11695 5 treated treat VBN cord-010092-uftc8inx 11695 6 products product NNS cord-010092-uftc8inx 11695 7 ( ( -LRB- cord-010092-uftc8inx 11695 8 platelets platelet NNS cord-010092-uftc8inx 11695 9 or or CC cord-010092-uftc8inx 11695 10 M M NNP cord-010092-uftc8inx 11695 11 - - HYPH cord-010092-uftc8inx 11695 12 PC pc NN cord-010092-uftc8inx 11695 13 and and CC cord-010092-uftc8inx 11695 14 plasma plasma NN cord-010092-uftc8inx 11695 15 or or CC cord-010092-uftc8inx 11695 16 M M NNP cord-010092-uftc8inx 11695 17 - - HYPH cord-010092-uftc8inx 11695 18 P P NNP cord-010092-uftc8inx 11695 19 ) ) -RRB- cord-010092-uftc8inx 11695 20 are be VBP cord-010092-uftc8inx 11695 21 included include VBN cord-010092-uftc8inx 11695 22 from from IN cord-010092-uftc8inx 11695 23 2012 2012 CD cord-010092-uftc8inx 11695 24 to to IN cord-010092-uftc8inx 11695 25 2017 2017 CD cord-010092-uftc8inx 11695 26 as as IN cord-010092-uftc8inx 11695 27 blood blood NN cord-010092-uftc8inx 11695 28 centers center NNS cord-010092-uftc8inx 11695 29 started start VBD cord-010092-uftc8inx 11695 30 to to TO cord-010092-uftc8inx 11695 31 apply apply VB cord-010092-uftc8inx 11695 32 the the DT cord-010092-uftc8inx 11695 33 technology technology NN cord-010092-uftc8inx 11695 34 in in IN cord-010092-uftc8inx 11695 35 routine routine NN cord-010092-uftc8inx 11695 36 . . . cord-010092-uftc8inx 11696 1 Results result NNS cord-010092-uftc8inx 11696 2 : : : cord-010092-uftc8inx 11697 1 Increase increase VB cord-010092-uftc8inx 11698 1 adoption adoption NN cord-010092-uftc8inx 11698 2 of of IN cord-010092-uftc8inx 11698 3 the the DT cord-010092-uftc8inx 11698 4 Mirasol Mirasol NNP cord-010092-uftc8inx 11698 5 system system NN cord-010092-uftc8inx 11698 6 is be VBZ cord-010092-uftc8inx 11698 7 observed observe VBN cord-010092-uftc8inx 11698 8 between between IN cord-010092-uftc8inx 11698 9 2012 2012 CD cord-010092-uftc8inx 11698 10 , , , cord-010092-uftc8inx 11698 11 when when WRB cord-010092-uftc8inx 11698 12 4,196 4,196 CD cord-010092-uftc8inx 11698 13 Mirasol Mirasol NNP cord-010092-uftc8inx 11698 14 treated treat VBD cord-010092-uftc8inx 11698 15 blood blood NN cord-010092-uftc8inx 11698 16 products product NNS cord-010092-uftc8inx 11698 17 were be VBD cord-010092-uftc8inx 11698 18 issued issue VBN cord-010092-uftc8inx 11698 19 to to IN cord-010092-uftc8inx 11698 20 hospitals hospital NNS cord-010092-uftc8inx 11698 21 and and CC cord-010092-uftc8inx 11698 22 2017 2017 CD cord-010092-uftc8inx 11698 23 with with IN cord-010092-uftc8inx 11698 24 56,229 56,229 CD cord-010092-uftc8inx 11698 25 Mirasol Mirasol NNP cord-010092-uftc8inx 11698 26 products product NNS cord-010092-uftc8inx 11698 27 issued issue VBN cord-010092-uftc8inx 11698 28 . . . cord-010092-uftc8inx 11699 1 Due due IN cord-010092-uftc8inx 11699 2 to to IN cord-010092-uftc8inx 11699 3 low low JJ cord-010092-uftc8inx 11699 4 number number NN cord-010092-uftc8inx 11699 5 of of IN cord-010092-uftc8inx 11699 6 transfusions transfusion NNS cord-010092-uftc8inx 11699 7 of of IN cord-010092-uftc8inx 11699 8 Mirasol Mirasol NNP cord-010092-uftc8inx 11699 9 - - HYPH cord-010092-uftc8inx 11699 10 treated treat VBN cord-010092-uftc8inx 11699 11 blood blood NN cord-010092-uftc8inx 11699 12 components component NNS cord-010092-uftc8inx 11699 13 in in IN cord-010092-uftc8inx 11699 14 2012 2012 CD cord-010092-uftc8inx 11699 15 and and CC cord-010092-uftc8inx 11699 16 2013 2013 CD cord-010092-uftc8inx 11699 17 , , , cord-010092-uftc8inx 11699 18 notification notification NN cord-010092-uftc8inx 11699 19 rates rate NNS cord-010092-uftc8inx 11699 20 began begin VBD cord-010092-uftc8inx 11699 21 to to TO cord-010092-uftc8inx 11699 22 be be VB cord-010092-uftc8inx 11699 23 analyzed analyze VBN cord-010092-uftc8inx 11699 24 in in IN cord-010092-uftc8inx 11699 25 2014 2014 CD cord-010092-uftc8inx 11699 26 , , , cord-010092-uftc8inx 11699 27 showing show VBG cord-010092-uftc8inx 11699 28 AE AE NNP cord-010092-uftc8inx 11699 29 rates rate NNS cord-010092-uftc8inx 11699 30 of of IN cord-010092-uftc8inx 11699 31 0.2 0.2 CD cord-010092-uftc8inx 11699 32 % % NN cord-010092-uftc8inx 11699 33 , , , cord-010092-uftc8inx 11699 34 similar similar JJ cord-010092-uftc8inx 11699 35 to to IN cord-010092-uftc8inx 11699 36 reports report NNS cord-010092-uftc8inx 11699 37 at at IN cord-010092-uftc8inx 11699 38 the the DT cord-010092-uftc8inx 11699 39 national national JJ cord-010092-uftc8inx 11699 40 level level NN cord-010092-uftc8inx 11699 41 . . . cord-010092-uftc8inx 11700 1 Stable stable JJ cord-010092-uftc8inx 11700 2 transfusion transfusion NN cord-010092-uftc8inx 11700 3 reaction reaction NN cord-010092-uftc8inx 11700 4 rates rate NNS cord-010092-uftc8inx 11700 5 were be VBD cord-010092-uftc8inx 11700 6 observed observe VBN cord-010092-uftc8inx 11700 7 with with IN cord-010092-uftc8inx 11700 8 M M NNP cord-010092-uftc8inx 11700 9 - - HYPH cord-010092-uftc8inx 11700 10 PC PC NNP cord-010092-uftc8inx 11700 11 ( ( -LRB- cord-010092-uftc8inx 11700 12 around around RB cord-010092-uftc8inx 11700 13 0.23 0.23 CD cord-010092-uftc8inx 11700 14 ) ) -RRB- cord-010092-uftc8inx 11700 15 . . . cord-010092-uftc8inx 11701 1 Rate rate NN cord-010092-uftc8inx 11701 2 of of IN cord-010092-uftc8inx 11701 3 AE AE NNP cord-010092-uftc8inx 11701 4 after after IN cord-010092-uftc8inx 11701 5 transfusion transfusion NN cord-010092-uftc8inx 11701 6 of of IN cord-010092-uftc8inx 11701 7 M M NNP cord-010092-uftc8inx 11701 8 - - HYPH cord-010092-uftc8inx 11701 9 P P NNP cord-010092-uftc8inx 11701 10 is be VBZ cord-010092-uftc8inx 11701 11 fluctuant fluctuant JJ cord-010092-uftc8inx 11701 12 between between IN cord-010092-uftc8inx 11701 13 0.06 0.06 CD cord-010092-uftc8inx 11701 14 and and CC cord-010092-uftc8inx 11701 15 0.17 0.17 CD cord-010092-uftc8inx 11701 16 . . . cord-010092-uftc8inx 11702 1 This this DT cord-010092-uftc8inx 11702 2 fluctuation fluctuation NN cord-010092-uftc8inx 11702 3 could could MD cord-010092-uftc8inx 11702 4 be be VB cord-010092-uftc8inx 11702 5 due due JJ cord-010092-uftc8inx 11702 6 to to IN cord-010092-uftc8inx 11702 7 the the DT cord-010092-uftc8inx 11702 8 inconsistent inconsistent JJ cord-010092-uftc8inx 11702 9 numbers number NNS cord-010092-uftc8inx 11702 10 of of IN cord-010092-uftc8inx 11702 11 M M NNP cord-010092-uftc8inx 11702 12 - - HYPH cord-010092-uftc8inx 11702 13 P P NNP cord-010092-uftc8inx 11702 14 transfused transfuse VBN cord-010092-uftc8inx 11702 15 from from IN cord-010092-uftc8inx 11702 16 one one CD cord-010092-uftc8inx 11702 17 year year NN cord-010092-uftc8inx 11702 18 to to IN cord-010092-uftc8inx 11702 19 the the DT cord-010092-uftc8inx 11702 20 other other JJ cord-010092-uftc8inx 11702 21 . . . cord-010092-uftc8inx 11703 1 Most Most JJS cord-010092-uftc8inx 11703 2 of of IN cord-010092-uftc8inx 11703 3 transfusion transfusion NN cord-010092-uftc8inx 11703 4 reactions reaction NNS cord-010092-uftc8inx 11703 5 ( ( -LRB- cord-010092-uftc8inx 11703 6 around around IN cord-010092-uftc8inx 11703 7 80 80 CD cord-010092-uftc8inx 11703 8 % % NN cord-010092-uftc8inx 11703 9 ) ) -RRB- cord-010092-uftc8inx 11703 10 were be VBD cord-010092-uftc8inx 11703 11 of of IN cord-010092-uftc8inx 11703 12 grade grade NN cord-010092-uftc8inx 11704 1 I -PRON- PRP cord-010092-uftc8inx 11704 2 severity severity NN cord-010092-uftc8inx 11704 3 and and CC cord-010092-uftc8inx 11704 4 grade grade NN cord-010092-uftc8inx 11704 5 II ii CD cord-010092-uftc8inx 11704 6 level level NN cord-010092-uftc8inx 11704 7 of of IN cord-010092-uftc8inx 11704 8 imputability imputability NN cord-010092-uftc8inx 11704 9 . . . cord-010092-uftc8inx 11705 1 Allergic allergic JJ cord-010092-uftc8inx 11705 2 reactions reaction NNS cord-010092-uftc8inx 11705 3 accounted account VBD cord-010092-uftc8inx 11705 4 for for IN cord-010092-uftc8inx 11705 5 most most JJS cord-010092-uftc8inx 11705 6 of of IN cord-010092-uftc8inx 11705 7 the the DT cord-010092-uftc8inx 11705 8 adverse adverse JJ cord-010092-uftc8inx 11705 9 events event NNS cord-010092-uftc8inx 11705 10 , , , cord-010092-uftc8inx 11705 11 with with IN cord-010092-uftc8inx 11705 12 G&I G&I NNP cord-010092-uftc8inx 11705 13 > > XX cord-010092-uftc8inx 11705 14 2 2 CD cord-010092-uftc8inx 11705 15 reactions reaction NNS cord-010092-uftc8inx 11705 16 in in IN cord-010092-uftc8inx 11705 17 2016 2016 CD cord-010092-uftc8inx 11705 18 and and CC cord-010092-uftc8inx 11705 19 2017 2017 CD cord-010092-uftc8inx 11705 20 of of IN cord-010092-uftc8inx 11705 21 respectively respectively RB cord-010092-uftc8inx 11705 22 0.18 0.18 CD cord-010092-uftc8inx 11705 23 and and CC cord-010092-uftc8inx 11705 24 0.07 0.07 CD cord-010092-uftc8inx 11705 25 No no DT cord-010092-uftc8inx 11705 26 bacterial bacterial JJ cord-010092-uftc8inx 11705 27 nor nor CC cord-010092-uftc8inx 11705 28 viral viral JJ cord-010092-uftc8inx 11705 29 transfusion transfusion NN cord-010092-uftc8inx 11705 30 transmission transmission NN cord-010092-uftc8inx 11705 31 was be VBD cord-010092-uftc8inx 11705 32 recorded record VBN cord-010092-uftc8inx 11705 33 on on IN cord-010092-uftc8inx 11705 34 Mirasol Mirasol NNP cord-010092-uftc8inx 11705 35 products product NNS cord-010092-uftc8inx 11705 36 during during IN cord-010092-uftc8inx 11705 37 the the DT cord-010092-uftc8inx 11705 38 study study NN cord-010092-uftc8inx 11705 39 period period NN cord-010092-uftc8inx 11705 40 ( ( -LRB- cord-010092-uftc8inx 11705 41 2012 2012 CD cord-010092-uftc8inx 11705 42 ) ) -RRB- cord-010092-uftc8inx 11705 43 ( ( -LRB- cord-010092-uftc8inx 11705 44 2013 2013 CD cord-010092-uftc8inx 11705 45 ) ) -RRB- cord-010092-uftc8inx 11706 1 ( ( -LRB- cord-010092-uftc8inx 11706 2 2014 2014 CD cord-010092-uftc8inx 11706 3 ) ) -RRB- cord-010092-uftc8inx 11706 4 ( ( -LRB- cord-010092-uftc8inx 11706 5 2015 2015 CD cord-010092-uftc8inx 11706 6 ) ) -RRB- cord-010092-uftc8inx 11706 7 ( ( -LRB- cord-010092-uftc8inx 11706 8 2016 2016 CD cord-010092-uftc8inx 11706 9 ) ) -RRB- cord-010092-uftc8inx 11706 10 ( ( -LRB- cord-010092-uftc8inx 11706 11 2017 2017 CD cord-010092-uftc8inx 11706 12 ) ) -RRB- cord-010092-uftc8inx 11706 13 . . . cord-010092-uftc8inx 11707 1 At at IN cord-010092-uftc8inx 11707 2 the the DT cord-010092-uftc8inx 11707 3 National national JJ cord-010092-uftc8inx 11707 4 level level NN cord-010092-uftc8inx 11707 5 , , , cord-010092-uftc8inx 11707 6 nine nine CD cord-010092-uftc8inx 11707 7 cases case NNS cord-010092-uftc8inx 11707 8 of of IN cord-010092-uftc8inx 11707 9 bacterial bacterial JJ cord-010092-uftc8inx 11707 10 transfusion transfusion NN cord-010092-uftc8inx 11707 11 transmission transmission NN cord-010092-uftc8inx 11707 12 ( ( -LRB- cord-010092-uftc8inx 11707 13 with with IN cord-010092-uftc8inx 11707 14 G&I G&I NNP cord-010092-uftc8inx 11707 15 > > XX cord-010092-uftc8inx 11707 16 2 2 CD cord-010092-uftc8inx 11707 17 ) ) -RRB- cord-010092-uftc8inx 11707 18 were be VBD cord-010092-uftc8inx 11707 19 reported report VBN cord-010092-uftc8inx 11707 20 . . . cord-010092-uftc8inx 11708 1 These these DT cord-010092-uftc8inx 11708 2 transmissions transmission NNS cord-010092-uftc8inx 11708 3 were be VBD cord-010092-uftc8inx 11708 4 probably probably RB cord-010092-uftc8inx 11708 5 due due JJ cord-010092-uftc8inx 11708 6 to to IN cord-010092-uftc8inx 11708 7 transfusion transfusion NN cord-010092-uftc8inx 11708 8 of of IN cord-010092-uftc8inx 11708 9 non non JJ cord-010092-uftc8inx 11708 10 - - JJ cord-010092-uftc8inx 11708 11 pathogen pathogen JJ cord-010092-uftc8inx 11708 12 reduced reduce VBN cord-010092-uftc8inx 11708 13 products product NNS cord-010092-uftc8inx 11708 14 . . . cord-010092-uftc8inx 11709 1 Summary Summary NNP cord-010092-uftc8inx 11709 2 / / SYM cord-010092-uftc8inx 11709 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 11709 4 : : : cord-010092-uftc8inx 11710 1 The the DT cord-010092-uftc8inx 11710 2 observed observed JJ cord-010092-uftc8inx 11710 3 notification notification NN cord-010092-uftc8inx 11710 4 rate rate NN cord-010092-uftc8inx 11710 5 of of IN cord-010092-uftc8inx 11710 6 AE AE NNP cord-010092-uftc8inx 11710 7 is be VBZ cord-010092-uftc8inx 11710 8 similar similar JJ cord-010092-uftc8inx 11710 9 to to IN cord-010092-uftc8inx 11710 10 the the DT cord-010092-uftc8inx 11710 11 national national JJ cord-010092-uftc8inx 11710 12 rate rate NN cord-010092-uftc8inx 11710 13 but but CC cord-010092-uftc8inx 11710 14 allergic allergic JJ cord-010092-uftc8inx 11710 15 reactions reaction NNS cord-010092-uftc8inx 11710 16 with with IN cord-010092-uftc8inx 11710 17 G&I G&I NNP cord-010092-uftc8inx 11710 18 > > XX cord-010092-uftc8inx 11711 1 2 2 CD cord-010092-uftc8inx 11711 2 is be VBZ cord-010092-uftc8inx 11711 3 inferior inferior JJ cord-010092-uftc8inx 11711 4 with with IN cord-010092-uftc8inx 11711 5 Mirasol Mirasol NNP cord-010092-uftc8inx 11711 6 treated treat VBN cord-010092-uftc8inx 11711 7 products product NNS cord-010092-uftc8inx 11711 8 . . . cord-010092-uftc8inx 11712 1 Also also RB cord-010092-uftc8inx 11712 2 , , , cord-010092-uftc8inx 11712 3 we -PRON- PRP cord-010092-uftc8inx 11712 4 found find VBD cord-010092-uftc8inx 11712 5 no no DT cord-010092-uftc8inx 11712 6 reports report NNS cord-010092-uftc8inx 11712 7 of of IN cord-010092-uftc8inx 11712 8 transfusion transfusion NN cord-010092-uftc8inx 11712 9 transmission transmission NN cord-010092-uftc8inx 11712 10 infections infection NNS cord-010092-uftc8inx 11712 11 nor nor CC cord-010092-uftc8inx 11712 12 cases case NNS cord-010092-uftc8inx 11712 13 of of IN cord-010092-uftc8inx 11712 14 transfusion transfusion NN cord-010092-uftc8inx 11712 15 associated associate VBN cord-010092-uftc8inx 11712 16 graft graft NN cord-010092-uftc8inx 11712 17 - - HYPH cord-010092-uftc8inx 11712 18 vs vs IN cord-010092-uftc8inx 11712 19 - - HYPH cord-010092-uftc8inx 11712 20 host host NN cord-010092-uftc8inx 11712 21 disease disease NN cord-010092-uftc8inx 11712 22 , , , cord-010092-uftc8inx 11712 23 demonstrating demonstrate VBG cord-010092-uftc8inx 11712 24 safety safety NN cord-010092-uftc8inx 11712 25 of of IN cord-010092-uftc8inx 11712 26 Mirasol Mirasol NNP cord-010092-uftc8inx 11712 27 treated treat VBN cord-010092-uftc8inx 11712 28 products product NNS cord-010092-uftc8inx 11712 29 . . . cord-010092-uftc8inx 11713 1 were be VBD cord-010092-uftc8inx 11713 2 attributed attribute VBN cord-010092-uftc8inx 11713 3 to to IN cord-010092-uftc8inx 11713 4 Human Human NNP cord-010092-uftc8inx 11713 5 Error Error NNP cord-010092-uftc8inx 11713 6 ( ( -LRB- cord-010092-uftc8inx 11713 7 75 75 CD cord-010092-uftc8inx 11713 8 % % NN cord-010092-uftc8inx 11713 9 ) ) -RRB- cord-010092-uftc8inx 11713 10 with with IN cord-010092-uftc8inx 11713 11 the the DT cord-010092-uftc8inx 11713 12 lowest low JJS cord-010092-uftc8inx 11713 13 frequency frequency NN cord-010092-uftc8inx 11713 14 in in IN cord-010092-uftc8inx 11713 15 Equipment Equipment NNP cord-010092-uftc8inx 11713 16 Failure failure NN cord-010092-uftc8inx 11713 17 ( ( -LRB- cord-010092-uftc8inx 11713 18 10 10 CD cord-010092-uftc8inx 11713 19 % % NN cord-010092-uftc8inx 11713 20 ) ) -RRB- cord-010092-uftc8inx 11713 21 , , , cord-010092-uftc8inx 11713 22 compared compare VBN cord-010092-uftc8inx 11713 23 to to IN cord-010092-uftc8inx 11713 24 21 21 CD cord-010092-uftc8inx 11713 25 % % NN cord-010092-uftc8inx 11713 26 and and CC cord-010092-uftc8inx 11713 27 29 29 CD cord-010092-uftc8inx 11713 28 % % NN cord-010092-uftc8inx 11713 29 , , , cord-010092-uftc8inx 11713 30 respectively respectively RB cord-010092-uftc8inx 11713 31 , , , cord-010092-uftc8inx 11713 32 in in IN cord-010092-uftc8inx 11713 33 the the DT cord-010092-uftc8inx 11713 34 following follow VBG cord-010092-uftc8inx 11713 35 three three CD cord-010092-uftc8inx 11713 36 years year NNS cord-010092-uftc8inx 11713 37 . . . cord-010092-uftc8inx 11714 1 Root root NN cord-010092-uftc8inx 11714 2 cause cause NN cord-010092-uftc8inx 11714 3 analysis analysis NN cord-010092-uftc8inx 11714 4 demonstrated demonstrate VBD cord-010092-uftc8inx 11714 5 failures failure NNS cord-010092-uftc8inx 11714 6 in in IN cord-010092-uftc8inx 11714 7 the the DT cord-010092-uftc8inx 11714 8 Quality Quality NNP cord-010092-uftc8inx 11714 9 Management Management NNP cord-010092-uftc8inx 11714 10 System System NNP cord-010092-uftc8inx 11714 11 including include VBG cord-010092-uftc8inx 11714 12 failures failure NNS cord-010092-uftc8inx 11714 13 in in IN cord-010092-uftc8inx 11714 14 administration administration NN cord-010092-uftc8inx 11714 15 , , , cord-010092-uftc8inx 11714 16 inadequate inadequate JJ cord-010092-uftc8inx 11714 17 staffing staffing NN cord-010092-uftc8inx 11714 18 for for IN cord-010092-uftc8inx 11714 19 blood blood NN cord-010092-uftc8inx 11714 20 collection collection NN cord-010092-uftc8inx 11714 21 as as RB cord-010092-uftc8inx 11714 22 well well RB cord-010092-uftc8inx 11714 23 as as IN cord-010092-uftc8inx 11714 24 in in IN cord-010092-uftc8inx 11714 25 distribution distribution NN cord-010092-uftc8inx 11714 26 and and CC cord-010092-uftc8inx 11714 27 processing processing NN cord-010092-uftc8inx 11714 28 , , , cord-010092-uftc8inx 11714 29 and and CC cord-010092-uftc8inx 11714 30 failures failure NNS cord-010092-uftc8inx 11714 31 arising arise VBG cord-010092-uftc8inx 11714 32 from from IN cord-010092-uftc8inx 11714 33 institutional institutional JJ cord-010092-uftc8inx 11714 34 constraints constraint NNS cord-010092-uftc8inx 11714 35 and and CC cord-010092-uftc8inx 11714 36 system system NN cord-010092-uftc8inx 11714 37 failures failure NNS cord-010092-uftc8inx 11714 38 in in IN cord-010092-uftc8inx 11714 39 hospital hospital NN cord-010092-uftc8inx 11714 40 management management NN cord-010092-uftc8inx 11714 41 . . . cord-010092-uftc8inx 11715 1 High high JJ cord-010092-uftc8inx 11715 2 numbers number NNS cord-010092-uftc8inx 11715 3 of of IN cord-010092-uftc8inx 11715 4 " " `` cord-010092-uftc8inx 11715 5 Other other JJ cord-010092-uftc8inx 11715 6 " " '' cord-010092-uftc8inx 11715 7 AEs ae NNS cord-010092-uftc8inx 11715 8 ( ( -LRB- cord-010092-uftc8inx 11715 9 25 25 CD cord-010092-uftc8inx 11715 10 % % NN cord-010092-uftc8inx 11715 11 ) ) -RRB- cord-010092-uftc8inx 11715 12 in in IN cord-010092-uftc8inx 11715 13 distribution distribution NN cord-010092-uftc8inx 11715 14 and and CC cord-010092-uftc8inx 11715 15 whole whole JJ cord-010092-uftc8inx 11715 16 blood blood NN cord-010092-uftc8inx 11715 17 collection collection NN cord-010092-uftc8inx 11715 18 call call NN cord-010092-uftc8inx 11715 19 for for IN cord-010092-uftc8inx 11715 20 further further JJ cord-010092-uftc8inx 11715 21 investigation investigation NN cord-010092-uftc8inx 11715 22 to to TO cord-010092-uftc8inx 11715 23 indicate indicate VB cord-010092-uftc8inx 11715 24 measures measure NNS cord-010092-uftc8inx 11715 25 necessary necessary JJ cord-010092-uftc8inx 11715 26 for for IN cord-010092-uftc8inx 11715 27 prevention prevention NN cord-010092-uftc8inx 11715 28 and and CC cord-010092-uftc8inx 11715 29 correction correction NN cord-010092-uftc8inx 11715 30 . . . cord-010092-uftc8inx 11716 1 Errors error NNS cord-010092-uftc8inx 11716 2 related relate VBN cord-010092-uftc8inx 11716 3 to to IN cord-010092-uftc8inx 11716 4 incorrect incorrect JJ cord-010092-uftc8inx 11716 5 blood blood NN cord-010092-uftc8inx 11716 6 component component NN cord-010092-uftc8inx 11716 7 transfused transfuse VBN cord-010092-uftc8inx 11716 8 ( ( -LRB- cord-010092-uftc8inx 11716 9 IBCT IBCT NNP cord-010092-uftc8inx 11716 10 ) ) -RRB- cord-010092-uftc8inx 11716 11 in in IN cord-010092-uftc8inx 11716 12 2007 2007 CD cord-010092-uftc8inx 11716 13 - - SYM cord-010092-uftc8inx 11716 14 2017 2017 CD cord-010092-uftc8inx 11717 1 were be VBD cord-010092-uftc8inx 11717 2 80 80 CD cord-010092-uftc8inx 11717 3 in in IN cord-010092-uftc8inx 11717 4 8,385,448 8,385,448 CD cord-010092-uftc8inx 11717 5 blood blood NN cord-010092-uftc8inx 11717 6 units unit NNS cord-010092-uftc8inx 11717 7 ( ( -LRB- cord-010092-uftc8inx 11717 8 1/104,818 1/104,818 CD cord-010092-uftc8inx 11717 9 ) ) -RRB- cord-010092-uftc8inx 11717 10 issued issue VBN cord-010092-uftc8inx 11717 11 for for IN cord-010092-uftc8inx 11717 12 transfusion transfusion NN cord-010092-uftc8inx 11717 13 . . . cord-010092-uftc8inx 11718 1 These these DT cord-010092-uftc8inx 11718 2 resulted result VBD cord-010092-uftc8inx 11718 3 in in IN cord-010092-uftc8inx 11718 4 27 27 CD cord-010092-uftc8inx 11718 5 serious serious JJ cord-010092-uftc8inx 11718 6 reactions reaction NNS cord-010092-uftc8inx 11718 7 ( ( -LRB- cord-010092-uftc8inx 11718 8 34 34 CD cord-010092-uftc8inx 11718 9 % % NN cord-010092-uftc8inx 11718 10 ) ) -RRB- cord-010092-uftc8inx 11718 11 ( ( -LRB- cord-010092-uftc8inx 11718 12 1 1 CD cord-010092-uftc8inx 11718 13 fatal fatal JJ cord-010092-uftc8inx 11718 14 , , , cord-010092-uftc8inx 11718 15 11 11 CD cord-010092-uftc8inx 11718 16 life life NN cord-010092-uftc8inx 11718 17 - - HYPH cord-010092-uftc8inx 11718 18 threatening threaten VBG cord-010092-uftc8inx 11718 19 ) ) -RRB- cord-010092-uftc8inx 11718 20 . . . cord-010092-uftc8inx 11719 1 Another another DT cord-010092-uftc8inx 11719 2 21 21 CD cord-010092-uftc8inx 11719 3 ( ( -LRB- cord-010092-uftc8inx 11719 4 26 26 CD cord-010092-uftc8inx 11719 5 % % NN cord-010092-uftc8inx 11719 6 ) ) -RRB- cord-010092-uftc8inx 11719 7 were be VBD cord-010092-uftc8inx 11719 8 related relate VBN cord-010092-uftc8inx 11719 9 with with IN cord-010092-uftc8inx 11719 10 IBCT IBCT NNP cord-010092-uftc8inx 11719 11 that that WDT cord-010092-uftc8inx 11719 12 did do VBD cord-010092-uftc8inx 11719 13 not not RB cord-010092-uftc8inx 11719 14 cause cause VB cord-010092-uftc8inx 11719 15 a a DT cord-010092-uftc8inx 11719 16 reaction reaction NN cord-010092-uftc8inx 11719 17 . . . cord-010092-uftc8inx 11720 1 Near near IN cord-010092-uftc8inx 11720 2 misses miss NNS cord-010092-uftc8inx 11720 3 ( ( -LRB- cord-010092-uftc8inx 11720 4 component component NN cord-010092-uftc8inx 11720 5 not not RB cord-010092-uftc8inx 11720 6 transfused transfuse VBN cord-010092-uftc8inx 11720 7 ) ) -RRB- cord-010092-uftc8inx 11720 8 were be VBD cord-010092-uftc8inx 11720 9 24 24 CD cord-010092-uftc8inx 11720 10 ( ( -LRB- cord-010092-uftc8inx 11720 11 40 40 CD cord-010092-uftc8inx 11720 12 % % NN cord-010092-uftc8inx 11720 13 ) ) -RRB- cord-010092-uftc8inx 11721 1 Summary Summary NNP cord-010092-uftc8inx 11721 2 / / SYM cord-010092-uftc8inx 11721 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 11721 4 : : : cord-010092-uftc8inx 11722 1 Our -PRON- PRP$ cord-010092-uftc8inx 11722 2 data datum NNS cord-010092-uftc8inx 11722 3 demonstrate demonstrate VBP cord-010092-uftc8inx 11722 4 increasing increase VBG cord-010092-uftc8inx 11722 5 compliance compliance NN cord-010092-uftc8inx 11722 6 with with IN cord-010092-uftc8inx 11722 7 reporting reporting NN cord-010092-uftc8inx 11722 8 requirements requirement NNS cord-010092-uftc8inx 11722 9 . . . cord-010092-uftc8inx 11723 1 Questions question NNS cord-010092-uftc8inx 11723 2 about about IN cord-010092-uftc8inx 11723 3 the the DT cord-010092-uftc8inx 11723 4 initial initial JJ cord-010092-uftc8inx 11723 5 factors factor NNS cord-010092-uftc8inx 11723 6 for for IN cord-010092-uftc8inx 11723 7 deviations deviation NNS cord-010092-uftc8inx 11723 8 in in IN cord-010092-uftc8inx 11723 9 certain certain JJ cord-010092-uftc8inx 11723 10 activities activity NNS cord-010092-uftc8inx 11723 11 specifying specify VBG cord-010092-uftc8inx 11723 12 failures failure NNS cord-010092-uftc8inx 11723 13 in in IN cord-010092-uftc8inx 11723 14 equipment equipment NN cord-010092-uftc8inx 11723 15 and and CC cord-010092-uftc8inx 11723 16 materials material NNS cord-010092-uftc8inx 11723 17 due due JJ cord-010092-uftc8inx 11723 18 to to IN cord-010092-uftc8inx 11723 19 system system NN cord-010092-uftc8inx 11723 20 as as RB cord-010092-uftc8inx 11723 21 well well RB cord-010092-uftc8inx 11723 22 as as IN cord-010092-uftc8inx 11723 23 human human JJ cord-010092-uftc8inx 11723 24 errors error NNS cord-010092-uftc8inx 11723 25 , , , cord-010092-uftc8inx 11723 26 highlight highlight VB cord-010092-uftc8inx 11723 27 the the DT cord-010092-uftc8inx 11723 28 need need NN cord-010092-uftc8inx 11723 29 for for IN cord-010092-uftc8inx 11723 30 further further JJ cord-010092-uftc8inx 11723 31 specifications specification NNS cord-010092-uftc8inx 11723 32 beyond beyond IN cord-010092-uftc8inx 11723 33 " " `` cord-010092-uftc8inx 11723 34 other other JJ cord-010092-uftc8inx 11723 35 " " '' cord-010092-uftc8inx 11723 36 and and CC cord-010092-uftc8inx 11723 37 " " `` cord-010092-uftc8inx 11723 38 human human JJ cord-010092-uftc8inx 11723 39 error error NN cord-010092-uftc8inx 11723 40 " " '' cord-010092-uftc8inx 11723 41 . . . cord-010092-uftc8inx 11724 1 Background background NN cord-010092-uftc8inx 11724 2 : : : cord-010092-uftc8inx 11725 1 The the DT cord-010092-uftc8inx 11725 2 weakest weak JJS cord-010092-uftc8inx 11725 3 link link NN cord-010092-uftc8inx 11725 4 in in IN cord-010092-uftc8inx 11725 5 the the DT cord-010092-uftc8inx 11725 6 transfusion transfusion NN cord-010092-uftc8inx 11725 7 chain chain NN cord-010092-uftc8inx 11725 8 currently currently RB cord-010092-uftc8inx 11725 9 is be VBZ cord-010092-uftc8inx 11725 10 the the DT cord-010092-uftc8inx 11725 11 handling handling NN cord-010092-uftc8inx 11725 12 of of IN cord-010092-uftc8inx 11725 13 blood blood NN cord-010092-uftc8inx 11725 14 components component NNS cord-010092-uftc8inx 11725 15 after after IN cord-010092-uftc8inx 11725 16 their -PRON- PRP$ cord-010092-uftc8inx 11725 17 issue issue NN cord-010092-uftc8inx 11725 18 and and CC cord-010092-uftc8inx 11725 19 the the DT cord-010092-uftc8inx 11725 20 bedside bedside NN cord-010092-uftc8inx 11725 21 blood blood NN cord-010092-uftc8inx 11725 22 administration administration NN cord-010092-uftc8inx 11725 23 practices practice NNS cord-010092-uftc8inx 11725 24 . . . cord-010092-uftc8inx 11726 1 Aims aim VBZ cord-010092-uftc8inx 11726 2 : : : cord-010092-uftc8inx 11726 3 To to TO cord-010092-uftc8inx 11726 4 evaluate evaluate VB cord-010092-uftc8inx 11726 5 compliance compliance NN cord-010092-uftc8inx 11726 6 with with IN cord-010092-uftc8inx 11726 7 standard standard JJ cord-010092-uftc8inx 11726 8 procedures procedure NNS cord-010092-uftc8inx 11726 9 for for IN cord-010092-uftc8inx 11726 10 bedside bedside JJ cord-010092-uftc8inx 11726 11 blood blood NN cord-010092-uftc8inx 11726 12 transfusion transfusion NN cord-010092-uftc8inx 11726 13 practices practice NNS cord-010092-uftc8inx 11726 14 by by IN cord-010092-uftc8inx 11726 15 analysis analysis NN cord-010092-uftc8inx 11726 16 of of IN cord-010092-uftc8inx 11726 17 the the DT cord-010092-uftc8inx 11726 18 " " `` cord-010092-uftc8inx 11726 19 Transfusion transfusion NN cord-010092-uftc8inx 11726 20 feedback feedback NN cord-010092-uftc8inx 11726 21 forms form NNS cord-010092-uftc8inx 11726 22 " " '' cord-010092-uftc8inx 11726 23 in in IN cord-010092-uftc8inx 11726 24 a a DT cord-010092-uftc8inx 11726 25 tertiary tertiary JJ cord-010092-uftc8inx 11726 26 care care NN cord-010092-uftc8inx 11726 27 multi multi JJ cord-010092-uftc8inx 11726 28 - - JJ cord-010092-uftc8inx 11726 29 specialty specialty JJ cord-010092-uftc8inx 11726 30 hospital hospital NN cord-010092-uftc8inx 11726 31 setting setting NN cord-010092-uftc8inx 11726 32 . . . cord-010092-uftc8inx 11727 1 Methods method NNS cord-010092-uftc8inx 11727 2 : : : cord-010092-uftc8inx 11727 3 During during IN cord-010092-uftc8inx 11727 4 the the DT cord-010092-uftc8inx 11727 5 study study NN cord-010092-uftc8inx 11727 6 period period NN cord-010092-uftc8inx 11727 7 of of IN cord-010092-uftc8inx 11727 8 24 24 CD cord-010092-uftc8inx 11727 9 months month NNS cord-010092-uftc8inx 11727 10 , , , cord-010092-uftc8inx 11727 11 the the DT cord-010092-uftc8inx 11727 12 transfusion transfusion NN cord-010092-uftc8inx 11727 13 feedback feedback NN cord-010092-uftc8inx 11727 14 forms form NNS cord-010092-uftc8inx 11727 15 received receive VBN cord-010092-uftc8inx 11727 16 from from IN cord-010092-uftc8inx 11727 17 various various JJ cord-010092-uftc8inx 11727 18 clinical clinical JJ cord-010092-uftc8inx 11727 19 areas area NNS cord-010092-uftc8inx 11727 20 of of IN cord-010092-uftc8inx 11727 21 the the DT cord-010092-uftc8inx 11727 22 hospital hospital NN cord-010092-uftc8inx 11727 23 were be VBD cord-010092-uftc8inx 11727 24 studied study VBN cord-010092-uftc8inx 11727 25 with with IN cord-010092-uftc8inx 11727 26 special special JJ cord-010092-uftc8inx 11727 27 reference reference NN cord-010092-uftc8inx 11727 28 to to IN cord-010092-uftc8inx 11727 29 the the DT cord-010092-uftc8inx 11727 30 transfusion transfusion NN cord-010092-uftc8inx 11727 31 times time NNS cord-010092-uftc8inx 11727 32 . . . cord-010092-uftc8inx 11728 1 The the DT cord-010092-uftc8inx 11728 2 data datum NNS cord-010092-uftc8inx 11728 3 was be VBD cord-010092-uftc8inx 11728 4 categorized categorize VBN cord-010092-uftc8inx 11728 5 based base VBN cord-010092-uftc8inx 11728 6 on on IN cord-010092-uftc8inx 11728 7 the the DT cord-010092-uftc8inx 11728 8 patient patient NN cord-010092-uftc8inx 11728 9 's 's POS cord-010092-uftc8inx 11728 10 location location NN cord-010092-uftc8inx 11728 11 as as RB cord-010092-uftc8inx 11728 12 well well RB cord-010092-uftc8inx 11728 13 as as IN cord-010092-uftc8inx 11728 14 the the DT cord-010092-uftc8inx 11728 15 time time NN cord-010092-uftc8inx 11728 16 of of IN cord-010092-uftc8inx 11728 17 transfusion transfusion NN cord-010092-uftc8inx 11728 18 , , , cord-010092-uftc8inx 11728 19 whether whether IN cord-010092-uftc8inx 11728 20 done do VBN cord-010092-uftc8inx 11728 21 in in IN cord-010092-uftc8inx 11728 22 routine routine NN cord-010092-uftc8inx 11728 23 or or CC cord-010092-uftc8inx 11728 24 emergency emergency NN cord-010092-uftc8inx 11728 25 hours hour NNS cord-010092-uftc8inx 11728 26 . . . cord-010092-uftc8inx 11729 1 Results result NNS cord-010092-uftc8inx 11729 2 : : : cord-010092-uftc8inx 11729 3 42,403 42,403 CD cord-010092-uftc8inx 11729 4 blood blood NN cord-010092-uftc8inx 11729 5 components component NNS cord-010092-uftc8inx 11729 6 were be VBD cord-010092-uftc8inx 11729 7 issued issue VBN cord-010092-uftc8inx 11729 8 during during IN cord-010092-uftc8inx 11729 9 the the DT cord-010092-uftc8inx 11729 10 study study NN cord-010092-uftc8inx 11729 11 period period NN cord-010092-uftc8inx 11729 12 , , , cord-010092-uftc8inx 11729 13 while while IN cord-010092-uftc8inx 11729 14 transfusion transfusion NN cord-010092-uftc8inx 11729 15 feedback feedback NN cord-010092-uftc8inx 11729 16 forms form NNS cord-010092-uftc8inx 11729 17 for for IN cord-010092-uftc8inx 11729 18 37,816 37,816 CD cord-010092-uftc8inx 11729 19 components component NNS cord-010092-uftc8inx 11729 20 ( ( -LRB- cord-010092-uftc8inx 11729 21 89.1 89.1 CD cord-010092-uftc8inx 11729 22 % % NN cord-010092-uftc8inx 11729 23 ) ) -RRB- cord-010092-uftc8inx 11729 24 were be VBD cord-010092-uftc8inx 11729 25 received receive VBN cord-010092-uftc8inx 11729 26 in in IN cord-010092-uftc8inx 11729 27 the the DT cord-010092-uftc8inx 11729 28 transfusion transfusion NN cord-010092-uftc8inx 11729 29 medicine medicine NN cord-010092-uftc8inx 11729 30 department department NN cord-010092-uftc8inx 11729 31 . . . cord-010092-uftc8inx 11730 1 Delay delay VB cord-010092-uftc8inx 11730 2 in in IN cord-010092-uftc8inx 11730 3 starting start VBG cord-010092-uftc8inx 11730 4 the the DT cord-010092-uftc8inx 11730 5 transfusion transfusion NN cord-010092-uftc8inx 11730 6 ( ( -LRB- cord-010092-uftc8inx 11730 7 more more JJR cord-010092-uftc8inx 11730 8 than than IN cord-010092-uftc8inx 11730 9 30 30 CD cord-010092-uftc8inx 11730 10 min min NN cord-010092-uftc8inx 11730 11 after after IN cord-010092-uftc8inx 11730 12 issue issue NN cord-010092-uftc8inx 11730 13 ) ) -RRB- cord-010092-uftc8inx 11730 14 was be VBD cord-010092-uftc8inx 11730 15 observed observe VBN cord-010092-uftc8inx 11730 16 in in IN cord-010092-uftc8inx 11730 17 2965 2965 CD cord-010092-uftc8inx 11730 18 transfusion transfusion NN cord-010092-uftc8inx 11730 19 events event NNS cord-010092-uftc8inx 11730 20 ( ( -LRB- cord-010092-uftc8inx 11730 21 6.9 6.9 CD cord-010092-uftc8inx 11730 22 % % NN cord-010092-uftc8inx 11730 23 ) ) -RRB- cord-010092-uftc8inx 11730 24 . . . cord-010092-uftc8inx 11731 1 The the DT cord-010092-uftc8inx 11731 2 component component NN cord-010092-uftc8inx 11731 3 transfusion transfusion NN cord-010092-uftc8inx 11731 4 time time NN cord-010092-uftc8inx 11731 5 exceeded exceed VBD cord-010092-uftc8inx 11731 6 the the DT cord-010092-uftc8inx 11731 7 permissible permissible JJ cord-010092-uftc8inx 11731 8 limits limit NNS cord-010092-uftc8inx 11731 9 for for IN cord-010092-uftc8inx 11731 10 930 930 CD cord-010092-uftc8inx 11731 11 component component NN cord-010092-uftc8inx 11731 12 ( ( -LRB- cord-010092-uftc8inx 11731 13 2.1%).The 2.1%).the CD cord-010092-uftc8inx 11731 14 overall overall JJ cord-010092-uftc8inx 11731 15 total total JJ cord-010092-uftc8inx 11731 16 permissible permissible JJ cord-010092-uftc8inx 11731 17 time time NN cord-010092-uftc8inx 11731 18 for for IN cord-010092-uftc8inx 11731 19 completion completion NN cord-010092-uftc8inx 11731 20 of of IN cord-010092-uftc8inx 11731 21 components component NNS cord-010092-uftc8inx 11731 22 exceeded exceed VBD cord-010092-uftc8inx 11731 23 permissible permissible JJ cord-010092-uftc8inx 11731 24 limit limit NN cord-010092-uftc8inx 11731 25 in in IN cord-010092-uftc8inx 11731 26 2217 2217 CD cord-010092-uftc8inx 11731 27 ( ( -LRB- cord-010092-uftc8inx 11731 28 5.2 5.2 CD cord-010092-uftc8inx 11731 29 % % NN cord-010092-uftc8inx 11731 30 ) ) -RRB- cord-010092-uftc8inx 11731 31 of of IN cord-010092-uftc8inx 11731 32 transfusion transfusion NN cord-010092-uftc8inx 11731 33 events event NNS cord-010092-uftc8inx 11731 34 . . . cord-010092-uftc8inx 11732 1 The the DT cord-010092-uftc8inx 11732 2 pediatric pediatric JJ cord-010092-uftc8inx 11732 3 ward ward NN cord-010092-uftc8inx 11732 4 ( ( -LRB- cord-010092-uftc8inx 11732 5 23.9 23.9 CD cord-010092-uftc8inx 11732 6 % % NN cord-010092-uftc8inx 11732 7 ) ) -RRB- cord-010092-uftc8inx 11732 8 , , , cord-010092-uftc8inx 11732 9 ICU ICU NNP cord-010092-uftc8inx 11732 10 and and CC cord-010092-uftc8inx 11732 11 OT OT NNP cord-010092-uftc8inx 11732 12 complex complex NN cord-010092-uftc8inx 11732 13 ( ( -LRB- cord-010092-uftc8inx 11732 14 25.4 25.4 CD cord-010092-uftc8inx 11732 15 % % NN cord-010092-uftc8inx 11732 16 ) ) -RRB- cord-010092-uftc8inx 11732 17 were be VBD cord-010092-uftc8inx 11732 18 found find VBN cord-010092-uftc8inx 11732 19 to to TO cord-010092-uftc8inx 11732 20 be be VB cord-010092-uftc8inx 11732 21 the the DT cord-010092-uftc8inx 11732 22 most most RBS cord-010092-uftc8inx 11732 23 non non JJ cord-010092-uftc8inx 11732 24 - - JJ cord-010092-uftc8inx 11732 25 compliant compliant JJ cord-010092-uftc8inx 11732 26 delay delay NN cord-010092-uftc8inx 11732 27 in in IN cord-010092-uftc8inx 11732 28 transfusion transfusion NN cord-010092-uftc8inx 11732 29 , , , cord-010092-uftc8inx 11732 30 transfusion transfusion NN cord-010092-uftc8inx 11732 31 time time NN cord-010092-uftc8inx 11732 32 and and CC cord-010092-uftc8inx 11732 33 total total JJ cord-010092-uftc8inx 11732 34 transfusion transfusion NN cord-010092-uftc8inx 11732 35 time time NN cord-010092-uftc8inx 11732 36 . . . cord-010092-uftc8inx 11733 1 Amongst amongst IN cord-010092-uftc8inx 11733 2 the the DT cord-010092-uftc8inx 11733 3 2965 2965 CD cord-010092-uftc8inx 11733 4 delayed delay VBN cord-010092-uftc8inx 11733 5 transfusions transfusion NNS cord-010092-uftc8inx 11733 6 after after IN cord-010092-uftc8inx 11733 7 issue issue NN cord-010092-uftc8inx 11733 8 , , , cord-010092-uftc8inx 11733 9 2120 2120 CD cord-010092-uftc8inx 11733 10 ( ( -LRB- cord-010092-uftc8inx 11733 11 71.5 71.5 CD cord-010092-uftc8inx 11733 12 % % NN cord-010092-uftc8inx 11733 13 ) ) -RRB- cord-010092-uftc8inx 11733 14 were be VBD cord-010092-uftc8inx 11733 15 during during IN cord-010092-uftc8inx 11733 16 the the DT cord-010092-uftc8inx 11733 17 routine routine JJ cord-010092-uftc8inx 11733 18 hours hour NNS cord-010092-uftc8inx 11733 19 i.e. i.e. FW cord-010092-uftc8inx 11733 20 between between IN cord-010092-uftc8inx 11733 21 7 7 CD cord-010092-uftc8inx 11733 22 am am NN cord-010092-uftc8inx 11733 23 to to IN cord-010092-uftc8inx 11733 24 7 7 CD cord-010092-uftc8inx 11733 25 pm pm NN cord-010092-uftc8inx 11733 26 and and CC cord-010092-uftc8inx 11733 27 845 845 CD cord-010092-uftc8inx 11733 28 ( ( -LRB- cord-010092-uftc8inx 11733 29 28.5 28.5 CD cord-010092-uftc8inx 11733 30 % % NN cord-010092-uftc8inx 11733 31 ) ) -RRB- cord-010092-uftc8inx 11733 32 were be VBD cord-010092-uftc8inx 11733 33 in in IN cord-010092-uftc8inx 11733 34 the the DT cord-010092-uftc8inx 11733 35 non non JJ cord-010092-uftc8inx 11733 36 routine routine JJ cord-010092-uftc8inx 11733 37 hours hour NNS cord-010092-uftc8inx 11733 38 i.e. i.e. FW cord-010092-uftc8inx 11733 39 between between IN cord-010092-uftc8inx 11733 40 7 7 CD cord-010092-uftc8inx 11733 41 pm pm NN cord-010092-uftc8inx 11733 42 to to IN cord-010092-uftc8inx 11733 43 7 7 CD cord-010092-uftc8inx 11733 44 am am NN cord-010092-uftc8inx 11733 45 . . . cord-010092-uftc8inx 11734 1 Summary Summary NNP cord-010092-uftc8inx 11734 2 / / SYM cord-010092-uftc8inx 11734 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 11734 4 : : : cord-010092-uftc8inx 11735 1 The the DT cord-010092-uftc8inx 11735 2 audit audit NN cord-010092-uftc8inx 11735 3 of of IN cord-010092-uftc8inx 11735 4 bedside bedside NN cord-010092-uftc8inx 11735 5 blood blood NN cord-010092-uftc8inx 11735 6 transfusion transfusion NN cord-010092-uftc8inx 11735 7 practices practice NNS cord-010092-uftc8inx 11735 8 has have VBZ cord-010092-uftc8inx 11735 9 given give VBN cord-010092-uftc8inx 11735 10 us -PRON- PRP cord-010092-uftc8inx 11735 11 a a DT cord-010092-uftc8inx 11735 12 good good JJ cord-010092-uftc8inx 11735 13 insight insight NN cord-010092-uftc8inx 11735 14 into into IN cord-010092-uftc8inx 11735 15 various various JJ cord-010092-uftc8inx 11735 16 areas area NNS cord-010092-uftc8inx 11735 17 of of IN cord-010092-uftc8inx 11735 18 noncompliances noncompliance NNS cord-010092-uftc8inx 11735 19 as as RB cord-010092-uftc8inx 11735 20 well well RB cord-010092-uftc8inx 11735 21 as as IN cord-010092-uftc8inx 11735 22 the the DT cord-010092-uftc8inx 11735 23 predominant predominant JJ cord-010092-uftc8inx 11735 24 locations location NNS cord-010092-uftc8inx 11735 25 in in IN cord-010092-uftc8inx 11735 26 the the DT cord-010092-uftc8inx 11735 27 hospital hospital NN cord-010092-uftc8inx 11735 28 where where WRB cord-010092-uftc8inx 11735 29 the the DT cord-010092-uftc8inx 11735 30 practices practice NNS cord-010092-uftc8inx 11735 31 need need VBP cord-010092-uftc8inx 11735 32 to to TO cord-010092-uftc8inx 11735 33 strengthened strengthen VBN cord-010092-uftc8inx 11735 34 further further RB cord-010092-uftc8inx 11735 35 . . . cord-010092-uftc8inx 11736 1 Focused focused JJ cord-010092-uftc8inx 11736 2 training training NN cord-010092-uftc8inx 11736 3 program program NN cord-010092-uftc8inx 11736 4 on on IN cord-010092-uftc8inx 11736 5 safe safe JJ cord-010092-uftc8inx 11736 6 blood blood NN cord-010092-uftc8inx 11736 7 administration administration NN cord-010092-uftc8inx 11736 8 practices practice NNS cord-010092-uftc8inx 11736 9 for for IN cord-010092-uftc8inx 11736 10 all all DT cord-010092-uftc8inx 11736 11 staff staff NN cord-010092-uftc8inx 11736 12 involved involve VBN cord-010092-uftc8inx 11736 13 in in IN cord-010092-uftc8inx 11736 14 handling handling NN cord-010092-uftc8inx 11736 15 and and CC cord-010092-uftc8inx 11736 16 transfusion transfusion NN cord-010092-uftc8inx 11736 17 of of IN cord-010092-uftc8inx 11736 18 blood blood NN cord-010092-uftc8inx 11736 19 components component NNS cord-010092-uftc8inx 11736 20 is be VBZ cord-010092-uftc8inx 11736 21 now now RB cord-010092-uftc8inx 11736 22 planned plan VBN cord-010092-uftc8inx 11736 23 to to TO cord-010092-uftc8inx 11736 24 combat combat VB cord-010092-uftc8inx 11736 25 this this DT cord-010092-uftc8inx 11736 26 issue issue NN cord-010092-uftc8inx 11736 27 . . . cord-010092-uftc8inx 11737 1 Background background NN cord-010092-uftc8inx 11737 2 : : : cord-010092-uftc8inx 11738 1 The the DT cord-010092-uftc8inx 11738 2 international international JJ cord-010092-uftc8inx 11738 3 surveillance surveillance NN cord-010092-uftc8inx 11738 4 of of IN cord-010092-uftc8inx 11738 5 transfusion transfusion NN cord-010092-uftc8inx 11738 6 adverse adverse JJ cord-010092-uftc8inx 11738 7 reactions reaction NNS cord-010092-uftc8inx 11738 8 ( ( -LRB- cord-010092-uftc8inx 11738 9 ARs ar NNS cord-010092-uftc8inx 11738 10 ) ) -RRB- cord-010092-uftc8inx 11738 11 and and CC cord-010092-uftc8inx 11738 12 events event NNS cord-010092-uftc8inx 11738 13 ( ( -LRB- cord-010092-uftc8inx 11738 14 AEs AEs NNP cord-010092-uftc8inx 11738 15 ) ) -RRB- cord-010092-uftc8inx 11738 16 ( ( -LRB- cord-010092-uftc8inx 11738 17 ISTARE ISTARE NNP cord-010092-uftc8inx 11738 18 ) ) -RRB- cord-010092-uftc8inx 11738 19 of of IN cord-010092-uftc8inx 11738 20 the the DT cord-010092-uftc8inx 11738 21 International International NNP cord-010092-uftc8inx 11738 22 Haemovigilance Haemovigilance NNP cord-010092-uftc8inx 11738 23 Network Network NNP cord-010092-uftc8inx 11738 24 ( ( -LRB- cord-010092-uftc8inx 11738 25 IHN IHN NNP cord-010092-uftc8inx 11738 26 ) ) -RRB- cord-010092-uftc8inx 11738 27 collects collect VBZ cord-010092-uftc8inx 11738 28 aggregate aggregate JJ cord-010092-uftc8inx 11738 29 data datum NNS cord-010092-uftc8inx 11738 30 from from IN cord-010092-uftc8inx 11738 31 member member NN cord-010092-uftc8inx 11738 32 national national NNP cord-010092-uftc8inx 11738 33 haemovigilance haemovigilance NNP cord-010092-uftc8inx 11738 34 systems system NNS cord-010092-uftc8inx 11738 35 ( ( -LRB- cord-010092-uftc8inx 11738 36 HVS HVS NNP cord-010092-uftc8inx 11738 37 ) ) -RRB- cord-010092-uftc8inx 11738 38 in in IN cord-010092-uftc8inx 11738 39 order order NN cord-010092-uftc8inx 11738 40 to to TO cord-010092-uftc8inx 11738 41 estimate estimate VB cord-010092-uftc8inx 11738 42 the the DT cord-010092-uftc8inx 11738 43 morbidity morbidity NN cord-010092-uftc8inx 11738 44 and and CC cord-010092-uftc8inx 11738 45 mortality mortality NN cord-010092-uftc8inx 11738 46 of of IN cord-010092-uftc8inx 11738 47 blood blood NN cord-010092-uftc8inx 11738 48 transfusion transfusion NN cord-010092-uftc8inx 11738 49 in in IN cord-010092-uftc8inx 11738 50 a a DT cord-010092-uftc8inx 11738 51 holistic holistic JJ cord-010092-uftc8inx 11738 52 approach approach NN cord-010092-uftc8inx 11738 53 . . . cord-010092-uftc8inx 11739 1 The the DT cord-010092-uftc8inx 11739 2 ultimate ultimate JJ cord-010092-uftc8inx 11739 3 goal goal NN cord-010092-uftc8inx 11739 4 is be VBZ cord-010092-uftc8inx 11739 5 to to TO cord-010092-uftc8inx 11739 6 contribute contribute VB cord-010092-uftc8inx 11739 7 to to IN cord-010092-uftc8inx 11739 8 improving improve VBG cord-010092-uftc8inx 11739 9 the the DT cord-010092-uftc8inx 11739 10 safety safety NN cord-010092-uftc8inx 11739 11 of of IN cord-010092-uftc8inx 11739 12 transfusion transfusion NN cord-010092-uftc8inx 11739 13 by by IN cord-010092-uftc8inx 11739 14 close close JJ cord-010092-uftc8inx 11739 15 monitoring monitoring NN cord-010092-uftc8inx 11739 16 throughout throughout IN cord-010092-uftc8inx 11739 17 the the DT cord-010092-uftc8inx 11739 18 chain chain NN cord-010092-uftc8inx 11739 19 " " '' cord-010092-uftc8inx 11739 20 from from IN cord-010092-uftc8inx 11739 21 vein vein NN cord-010092-uftc8inx 11739 22 to to IN cord-010092-uftc8inx 11739 23 vein vein NN cord-010092-uftc8inx 11739 24 " " '' cord-010092-uftc8inx 11739 25 . . . cord-010092-uftc8inx 11740 1 Aims aim VBZ cord-010092-uftc8inx 11740 2 : : : cord-010092-uftc8inx 11740 3 We -PRON- PRP cord-010092-uftc8inx 11740 4 analyse analyse VBP cord-010092-uftc8inx 11740 5 recent recent JJ cord-010092-uftc8inx 11740 6 ISTARE ISTARE NNP cord-010092-uftc8inx 11740 7 data datum NNS cord-010092-uftc8inx 11740 8 on on IN cord-010092-uftc8inx 11740 9 suspected suspect VBN cord-010092-uftc8inx 11740 10 transfusion transfusion NN cord-010092-uftc8inx 11740 11 transmitted transmit VBN cord-010092-uftc8inx 11740 12 infections infection NNS cord-010092-uftc8inx 11740 13 ( ( -LRB- cord-010092-uftc8inx 11740 14 sTTIs sTTIs NFP cord-010092-uftc8inx 11740 15 ) ) -RRB- cord-010092-uftc8inx 11740 16 for for IN cord-010092-uftc8inx 11740 17 2013 2013 CD cord-010092-uftc8inx 11740 18 - - SYM cord-010092-uftc8inx 11740 19 2016 2016 CD cord-010092-uftc8inx 11740 20 in in IN cord-010092-uftc8inx 11740 21 comparison comparison NN cord-010092-uftc8inx 11740 22 to to IN cord-010092-uftc8inx 11740 23 previous previous JJ cord-010092-uftc8inx 11740 24 years year NNS cord-010092-uftc8inx 11740 25 of of IN cord-010092-uftc8inx 11740 26 surveillance surveillance NN cord-010092-uftc8inx 11740 27 , , , cord-010092-uftc8inx 11740 28 [ [ -LRB- cord-010092-uftc8inx 11740 29 2006 2006 CD cord-010092-uftc8inx 11740 30 ] ] -RRB- cord-010092-uftc8inx 11740 31 [ [ -LRB- cord-010092-uftc8inx 11740 32 2007 2007 CD cord-010092-uftc8inx 11740 33 ] ] -RRB- cord-010092-uftc8inx 11740 34 [ [ -LRB- cord-010092-uftc8inx 11740 35 2008 2008 CD cord-010092-uftc8inx 11740 36 ] ] -RRB- cord-010092-uftc8inx 11740 37 [ [ -LRB- cord-010092-uftc8inx 11740 38 2009 2009 CD cord-010092-uftc8inx 11740 39 ] ] -RRB- cord-010092-uftc8inx 11740 40 [ [ -LRB- cord-010092-uftc8inx 11740 41 2010 2010 CD cord-010092-uftc8inx 11740 42 ] ] -RRB- cord-010092-uftc8inx 11740 43 [ [ -LRB- cord-010092-uftc8inx 11740 44 2011 2011 CD cord-010092-uftc8inx 11740 45 ] ] -RRB- cord-010092-uftc8inx 11741 1 [ [ -LRB- cord-010092-uftc8inx 11741 2 2012 2012 CD cord-010092-uftc8inx 11741 3 ] ] -RRB- cord-010092-uftc8inx 11741 4 Methods method NNS cord-010092-uftc8inx 11741 5 : : : cord-010092-uftc8inx 11741 6 Annual annual JJ cord-010092-uftc8inx 11741 7 aggregate aggregate JJ cord-010092-uftc8inx 11741 8 data datum NNS cord-010092-uftc8inx 11741 9 from from IN cord-010092-uftc8inx 11741 10 IHN IHN NNP cord-010092-uftc8inx 11741 11 member member NN cord-010092-uftc8inx 11741 12 HVS HVS NNP cord-010092-uftc8inx 11741 13 on on IN cord-010092-uftc8inx 11741 14 transfusion transfusion NN cord-010092-uftc8inx 11741 15 associated associate VBN cord-010092-uftc8inx 11741 16 bacterial bacterial JJ cord-010092-uftc8inx 11741 17 , , , cord-010092-uftc8inx 11741 18 viral viral JJ cord-010092-uftc8inx 11741 19 and and CC cord-010092-uftc8inx 11741 20 parasitic parasitic JJ cord-010092-uftc8inx 11741 21 infections infection NNS cord-010092-uftc8inx 11741 22 collected collect VBN cord-010092-uftc8inx 11741 23 online online RB cord-010092-uftc8inx 11741 24 in in IN cord-010092-uftc8inx 11741 25 ISTARE ISTARE NNP cord-010092-uftc8inx 11741 26 are be VBP cord-010092-uftc8inx 11741 27 analyzed analyze VBN cord-010092-uftc8inx 11741 28 by by IN cord-010092-uftc8inx 11741 29 incidence incidence NN cord-010092-uftc8inx 11741 30 in in IN cord-010092-uftc8inx 11741 31 blood blood NN cord-010092-uftc8inx 11741 32 components component NNS cord-010092-uftc8inx 11741 33 ( ( -LRB- cord-010092-uftc8inx 11741 34 BCs BCs NNP cord-010092-uftc8inx 11741 35 ) ) -RRB- cord-010092-uftc8inx 11741 36 issued issue VBD cord-010092-uftc8inx 11741 37 for for IN cord-010092-uftc8inx 11741 38 transfusion transfusion NN cord-010092-uftc8inx 11741 39 , , , cord-010092-uftc8inx 11741 40 by by IN cord-010092-uftc8inx 11741 41 severity severity NN cord-010092-uftc8inx 11741 42 and and CC cord-010092-uftc8inx 11741 43 imputability imputability NN cord-010092-uftc8inx 11741 44 as as RB cord-010092-uftc8inx 11741 45 well well RB cord-010092-uftc8inx 11741 46 as as IN cord-010092-uftc8inx 11741 47 by by IN cord-010092-uftc8inx 11741 48 blood blood NN cord-010092-uftc8inx 11741 49 component component NN cord-010092-uftc8inx 11741 50 . . . cord-010092-uftc8inx 11742 1 ARs ar NNS cord-010092-uftc8inx 11742 2 with with IN cord-010092-uftc8inx 11742 3 definite definite JJ cord-010092-uftc8inx 11742 4 , , , cord-010092-uftc8inx 11742 5 probable probable JJ cord-010092-uftc8inx 11742 6 or or CC cord-010092-uftc8inx 11742 7 possible possible JJ cord-010092-uftc8inx 11742 8 imputability imputability NN cord-010092-uftc8inx 11742 9 were be VBD cord-010092-uftc8inx 11742 10 included include VBN cord-010092-uftc8inx 11742 11 in in IN cord-010092-uftc8inx 11742 12 the the DT cord-010092-uftc8inx 11742 13 analysis analysis NN cord-010092-uftc8inx 11742 14 . . . cord-010092-uftc8inx 11743 1 Trend trend NN cord-010092-uftc8inx 11743 2 analysis analysis NN cord-010092-uftc8inx 11743 3 is be VBZ cord-010092-uftc8inx 11743 4 performed perform VBN cord-010092-uftc8inx 11743 5 to to TO cord-010092-uftc8inx 11743 6 allow allow VB cord-010092-uftc8inx 11743 7 comparisons comparison NNS cord-010092-uftc8inx 11743 8 and and CC cord-010092-uftc8inx 11743 9 to to TO cord-010092-uftc8inx 11743 10 collect collect VB cord-010092-uftc8inx 11743 11 information information NN cord-010092-uftc8inx 11743 12 on on IN cord-010092-uftc8inx 11743 13 established establish VBN cord-010092-uftc8inx 11743 14 and and CC cord-010092-uftc8inx 11743 15 newly newly RB cord-010092-uftc8inx 11743 16 emerging emerge VBG cord-010092-uftc8inx 11743 17 infectious infectious JJ cord-010092-uftc8inx 11743 18 threats threat NNS cord-010092-uftc8inx 11743 19 of of IN cord-010092-uftc8inx 11743 20 blood blood NN cord-010092-uftc8inx 11743 21 transfusion transfusion NN cord-010092-uftc8inx 11743 22 . . . cord-010092-uftc8inx 11744 1 Results result NNS cord-010092-uftc8inx 11744 2 : : : cord-010092-uftc8inx 11745 1 For for IN cord-010092-uftc8inx 11745 2 2013 2013 CD cord-010092-uftc8inx 11745 3 - - SYM cord-010092-uftc8inx 11745 4 2016 2016 CD cord-010092-uftc8inx 11745 5 89 89 CD cord-010092-uftc8inx 11745 6 sets set NNS cord-010092-uftc8inx 11745 7 of of IN cord-010092-uftc8inx 11745 8 annual annual JJ cord-010092-uftc8inx 11745 9 aggregated aggregated JJ cord-010092-uftc8inx 11745 10 data datum NNS cord-010092-uftc8inx 11745 11 from from IN cord-010092-uftc8inx 11745 12 25 25 CD cord-010092-uftc8inx 11745 13 countries country NNS cord-010092-uftc8inx 11745 14 covering cover VBG cord-010092-uftc8inx 11745 15 85,521,393 85,521,393 CD cord-010092-uftc8inx 11745 16 BCs BCs NNP cord-010092-uftc8inx 11745 17 issued issue VBD cord-010092-uftc8inx 11745 18 were be VBD cord-010092-uftc8inx 11745 19 analyzed analyze VBN cord-010092-uftc8inx 11745 20 . . . cord-010092-uftc8inx 11746 1 All all DT cord-010092-uftc8inx 11746 2 ARs ar NNS cord-010092-uftc8inx 11746 3 totalled total VBD cord-010092-uftc8inx 11746 4 76,907 76,907 CD cord-010092-uftc8inx 11746 5 and and CC cord-010092-uftc8inx 11746 6 infectious infectious JJ cord-010092-uftc8inx 11746 7 ARs ar NNS cord-010092-uftc8inx 11747 1 amounted amount VBD cord-010092-uftc8inx 11747 2 to to IN cord-010092-uftc8inx 11747 3 285 285 CD cord-010092-uftc8inx 11747 4 ( ( -LRB- cord-010092-uftc8inx 11747 5 0.4 0.4 CD cord-010092-uftc8inx 11747 6 % % NN cord-010092-uftc8inx 11747 7 ) ) -RRB- cord-010092-uftc8inx 11747 8 . . . cord-010092-uftc8inx 11748 1 The the DT cord-010092-uftc8inx 11748 2 overall overall JJ cord-010092-uftc8inx 11748 3 incidence incidence NN cord-010092-uftc8inx 11748 4 of of IN cord-010092-uftc8inx 11748 5 the the DT cord-010092-uftc8inx 11748 6 infectious infectious JJ cord-010092-uftc8inx 11748 7 ARs ar NNS cord-010092-uftc8inx 11748 8 was be VBD cord-010092-uftc8inx 11748 9 0.33/ 0.33/ CD cord-010092-uftc8inx 11748 10 100,000 100,000 CD cord-010092-uftc8inx 11748 11 units unit NNS cord-010092-uftc8inx 11748 12 of of IN cord-010092-uftc8inx 11748 13 BCs BCs NNP cord-010092-uftc8inx 11748 14 issued issue VBD cord-010092-uftc8inx 11748 15 . . . cord-010092-uftc8inx 11749 1 Bacterial bacterial JJ cord-010092-uftc8inx 11749 2 infections infection NNS cord-010092-uftc8inx 11749 3 were be VBD cord-010092-uftc8inx 11749 4 the the DT cord-010092-uftc8inx 11749 5 most most RBS cord-010092-uftc8inx 11749 6 frequent frequent JJ cord-010092-uftc8inx 11749 7 ( ( -LRB- cord-010092-uftc8inx 11749 8 188 188 CD cord-010092-uftc8inx 11749 9 , , , cord-010092-uftc8inx 11749 10 66 66 CD cord-010092-uftc8inx 11749 11 % % NN cord-010092-uftc8inx 11749 12 ) ) -RRB- cord-010092-uftc8inx 11749 13 , , , cord-010092-uftc8inx 11749 14 next next JJ cord-010092-uftc8inx 11749 15 viral viral NN cord-010092-uftc8inx 11749 16 ( ( -LRB- cord-010092-uftc8inx 11749 17 84 84 CD cord-010092-uftc8inx 11749 18 , , , cord-010092-uftc8inx 11749 19 29.5 29.5 CD cord-010092-uftc8inx 11749 20 % % NN cord-010092-uftc8inx 11749 21 ) ) -RRB- cord-010092-uftc8inx 11749 22 and and CC cord-010092-uftc8inx 11749 23 then then RB cord-010092-uftc8inx 11749 24 parasitic parasitic JJ cord-010092-uftc8inx 11749 25 ( ( -LRB- cord-010092-uftc8inx 11749 26 13 13 CD cord-010092-uftc8inx 11749 27 , , , cord-010092-uftc8inx 11749 28 4.5 4.5 CD cord-010092-uftc8inx 11749 29 % % NN cord-010092-uftc8inx 11749 30 ) ) -RRB- cord-010092-uftc8inx 11749 31 . . . cord-010092-uftc8inx 11750 1 Serious serious JJ cord-010092-uftc8inx 11750 2 were be VBD cord-010092-uftc8inx 11750 3 46 46 CD cord-010092-uftc8inx 11750 4 % % NN cord-010092-uftc8inx 11750 5 and and CC cord-010092-uftc8inx 11750 6 there there EX cord-010092-uftc8inx 11750 7 were be VBD cord-010092-uftc8inx 11750 8 11 11 CD cord-010092-uftc8inx 11750 9 fatalities fatality NNS cord-010092-uftc8inx 11750 10 ( ( -LRB- cord-010092-uftc8inx 11750 11 3.9 3.9 CD cord-010092-uftc8inx 11750 12 % % NN cord-010092-uftc8inx 11750 13 , , , cord-010092-uftc8inx 11750 14 incidence incidence NN cord-010092-uftc8inx 11750 15 0.013/100,000 0.013/100,000 CD cord-010092-uftc8inx 11750 16 ) ) -RRB- cord-010092-uftc8inx 11750 17 . . . cord-010092-uftc8inx 11751 1 Nine nine CD cord-010092-uftc8inx 11751 2 deaths death NNS cord-010092-uftc8inx 11751 3 were be VBD cord-010092-uftc8inx 11751 4 attributed attribute VBN cord-010092-uftc8inx 11751 5 to to IN cord-010092-uftc8inx 11751 6 sepsis sepsis NN cord-010092-uftc8inx 11751 7 and and CC cord-010092-uftc8inx 11751 8 the the DT cord-010092-uftc8inx 11751 9 other other JJ cord-010092-uftc8inx 11751 10 two two CD cord-010092-uftc8inx 11751 11 were be VBD cord-010092-uftc8inx 11751 12 associated associate VBN cord-010092-uftc8inx 11751 13 with with IN cord-010092-uftc8inx 11751 14 non non JJ cord-010092-uftc8inx 11751 15 - - JJ cord-010092-uftc8inx 11751 16 malarial malarial JJ cord-010092-uftc8inx 11751 17 parasitic parasitic JJ cord-010092-uftc8inx 11751 18 pathogens pathogen NNS cord-010092-uftc8inx 11751 19 . . . cord-010092-uftc8inx 11752 1 One one CD cord-010092-uftc8inx 11752 2 Geotrichum Geotrichum NNP cord-010092-uftc8inx 11752 3 clavatum clavatum NN cord-010092-uftc8inx 11752 4 fungal fungal NN cord-010092-uftc8inx 11752 5 infection infection NN cord-010092-uftc8inx 11752 6 associated associate VBN cord-010092-uftc8inx 11752 7 with with IN cord-010092-uftc8inx 11752 8 apheresis apheresis NN cord-010092-uftc8inx 11752 9 platelets platelet NNS cord-010092-uftc8inx 11752 10 was be VBD cord-010092-uftc8inx 11752 11 reported report VBN cord-010092-uftc8inx 11752 12 as as IN cord-010092-uftc8inx 11752 13 a a DT cord-010092-uftc8inx 11752 14 free free JJ cord-010092-uftc8inx 11752 15 text text NN cord-010092-uftc8inx 11752 16 comment comment NN cord-010092-uftc8inx 11752 17 . . . cord-010092-uftc8inx 11753 1 This this DT cord-010092-uftc8inx 11753 2 very very RB cord-010092-uftc8inx 11753 3 rarely rarely RB cord-010092-uftc8inx 11753 4 recognized recognize VBD cord-010092-uftc8inx 11753 5 fungal fungal JJ cord-010092-uftc8inx 11753 6 pathogen pathogen NN cord-010092-uftc8inx 11753 7 caused cause VBD cord-010092-uftc8inx 11753 8 a a DT cord-010092-uftc8inx 11753 9 very very RB cord-010092-uftc8inx 11753 10 severe severe JJ cord-010092-uftc8inx 11753 11 infection infection NN cord-010092-uftc8inx 11753 12 in in IN cord-010092-uftc8inx 11753 13 a a DT cord-010092-uftc8inx 11753 14 patient patient NN cord-010092-uftc8inx 11753 15 but but CC cord-010092-uftc8inx 11753 16 the the DT cord-010092-uftc8inx 11753 17 route route NN cord-010092-uftc8inx 11753 18 of of IN cord-010092-uftc8inx 11753 19 transmission transmission NN cord-010092-uftc8inx 11753 20 is be VBZ cord-010092-uftc8inx 11753 21 inconclusive inconclusive JJ cord-010092-uftc8inx 11753 22 . . . cord-010092-uftc8inx 11754 1 The the DT cord-010092-uftc8inx 11754 2 84 84 CD cord-010092-uftc8inx 11754 3 viral viral JJ cord-010092-uftc8inx 11754 4 sTTIs sTTIs NNP cord-010092-uftc8inx 11754 5 included include VBD cord-010092-uftc8inx 11754 6 17 17 CD cord-010092-uftc8inx 11754 7 HBV HBV NNP cord-010092-uftc8inx 11754 8 ( ( -LRB- cord-010092-uftc8inx 11754 9 20 20 CD cord-010092-uftc8inx 11754 10 % % NN cord-010092-uftc8inx 11754 11 ) ) -RRB- cord-010092-uftc8inx 11754 12 , , , cord-010092-uftc8inx 11754 13 10 10 CD cord-010092-uftc8inx 11754 14 HCV HCV NNP cord-010092-uftc8inx 11754 15 ( ( -LRB- cord-010092-uftc8inx 11754 16 12 12 CD cord-010092-uftc8inx 11754 17 % % NN cord-010092-uftc8inx 11754 18 ) ) -RRB- cord-010092-uftc8inx 11754 19 and and CC cord-010092-uftc8inx 11754 20 2 2 CD cord-010092-uftc8inx 11754 21 HIV HIV NNP cord-010092-uftc8inx 11754 22 ( ( -LRB- cord-010092-uftc8inx 11754 23 2.5 2.5 CD cord-010092-uftc8inx 11754 24 % % NN cord-010092-uftc8inx 11754 25 ) ) -RRB- cord-010092-uftc8inx 11754 26 . . . cord-010092-uftc8inx 11755 1 The the DT cord-010092-uftc8inx 11755 2 55 55 CD cord-010092-uftc8inx 11755 3 recorded record VBD cord-010092-uftc8inx 11755 4 as as IN cord-010092-uftc8inx 11755 5 " " `` cord-010092-uftc8inx 11755 6 Other other JJ cord-010092-uftc8inx 11755 7 " " '' cord-010092-uftc8inx 11755 8 ( ( -LRB- cord-010092-uftc8inx 11755 9 65.5 65.5 CD cord-010092-uftc8inx 11755 10 % % NN cord-010092-uftc8inx 11755 11 ) ) -RRB- cord-010092-uftc8inx 11755 12 including include VBG cord-010092-uftc8inx 11755 13 24 24 CD cord-010092-uftc8inx 11755 14 cases case NNS cord-010092-uftc8inx 11755 15 of of IN cord-010092-uftc8inx 11755 16 HEV hev NN cord-010092-uftc8inx 11755 17 , , , cord-010092-uftc8inx 11755 18 one one CD cord-010092-uftc8inx 11755 19 case case NN cord-010092-uftc8inx 11755 20 of of IN cord-010092-uftc8inx 11755 21 Parvovirus Parvovirus NNP cord-010092-uftc8inx 11755 22 B19 B19 NNP cord-010092-uftc8inx 11755 23 , , , cord-010092-uftc8inx 11755 24 one one CD cord-010092-uftc8inx 11755 25 CMV CMV NNP cord-010092-uftc8inx 11755 26 and and CC cord-010092-uftc8inx 11755 27 one one CD cord-010092-uftc8inx 11755 28 EBV EBV NNP cord-010092-uftc8inx 11755 29 . . . cord-010092-uftc8inx 11756 1 No no DT cord-010092-uftc8inx 11756 2 case case NN cord-010092-uftc8inx 11756 3 of of IN cord-010092-uftc8inx 11756 4 TT TT NNP cord-010092-uftc8inx 11756 5 - - HYPH cord-010092-uftc8inx 11756 6 malaria malaria NNP cord-010092-uftc8inx 11756 7 was be VBD cord-010092-uftc8inx 11756 8 reported report VBN cord-010092-uftc8inx 11756 9 . . . cord-010092-uftc8inx 11757 1 Other other JJ cord-010092-uftc8inx 11757 2 sTT sTT NNS cord-010092-uftc8inx 11757 3 - - HYPH cord-010092-uftc8inx 11757 4 PI PI NNP cord-010092-uftc8inx 11757 5 were be VBD cord-010092-uftc8inx 11757 6 15 15 CD cord-010092-uftc8inx 11757 7 ( ( -LRB- cord-010092-uftc8inx 11757 8 two two CD cord-010092-uftc8inx 11757 9 fatal fatal JJ cord-010092-uftc8inx 11757 10 ) ) -RRB- cord-010092-uftc8inx 11757 11 . . . cord-010092-uftc8inx 11758 1 The the DT cord-010092-uftc8inx 11758 2 prevailing prevail VBG cord-010092-uftc8inx 11758 3 BCs BCs NNPS cord-010092-uftc8inx 11758 4 were be VBD cord-010092-uftc8inx 11758 5 in in IN cord-010092-uftc8inx 11758 6 general general JJ cord-010092-uftc8inx 11758 7 RBCs rbc NNS cord-010092-uftc8inx 11758 8 followed follow VBN cord-010092-uftc8inx 11758 9 by by IN cord-010092-uftc8inx 11758 10 platelets platelet NNS cord-010092-uftc8inx 11758 11 . . . cord-010092-uftc8inx 11759 1 Comparison comparison NN cord-010092-uftc8inx 11759 2 with with IN cord-010092-uftc8inx 11759 3 corresponding correspond VBG cord-010092-uftc8inx 11759 4 data datum NNS cord-010092-uftc8inx 11759 5 for for IN cord-010092-uftc8inx 11759 6 2006 2006 CD cord-010092-uftc8inx 11759 7 - - SYM cord-010092-uftc8inx 11759 8 2012 2012 CD cord-010092-uftc8inx 11759 9 shows show VBZ cord-010092-uftc8inx 11759 10 a a DT cord-010092-uftc8inx 11759 11 consistent consistent JJ cord-010092-uftc8inx 11759 12 overall overall JJ cord-010092-uftc8inx 11759 13 incidence incidence NN cord-010092-uftc8inx 11759 14 in in IN cord-010092-uftc8inx 11759 15 total total JJ cord-010092-uftc8inx 11759 16 sTTIs sTTIs NNP cord-010092-uftc8inx 11759 17 ( ( -LRB- cord-010092-uftc8inx 11759 18 0.33 0.33 CD cord-010092-uftc8inx 11759 19 vs vs IN cord-010092-uftc8inx 11759 20 0.4/100,000 0.4/100,000 CD cord-010092-uftc8inx 11759 21 ) ) -RRB- cord-010092-uftc8inx 11759 22 . . . cord-010092-uftc8inx 11760 1 However however RB cord-010092-uftc8inx 11760 2 , , , cord-010092-uftc8inx 11760 3 considerable considerable JJ cord-010092-uftc8inx 11760 4 differences difference NNS cord-010092-uftc8inx 11760 5 were be VBD cord-010092-uftc8inx 11760 6 seen see VBN cord-010092-uftc8inx 11760 7 in in IN cord-010092-uftc8inx 11760 8 separate separate JJ cord-010092-uftc8inx 11760 9 categories category NNS cord-010092-uftc8inx 11760 10 , , , cord-010092-uftc8inx 11760 11 such such JJ cord-010092-uftc8inx 11760 12 as as IN cord-010092-uftc8inx 11760 13 bacterial bacterial JJ cord-010092-uftc8inx 11760 14 infections infection NNS cord-010092-uftc8inx 11760 15 ( ( -LRB- cord-010092-uftc8inx 11760 16 significantly significantly RB cord-010092-uftc8inx 11760 17 increased increase VBN cord-010092-uftc8inx 11760 18 rate rate NN cord-010092-uftc8inx 11760 19 in in IN cord-010092-uftc8inx 11760 20 2013 2013 CD cord-010092-uftc8inx 11760 21 - - SYM cord-010092-uftc8inx 11760 22 2016 2016 CD cord-010092-uftc8inx 11760 23 , , , cord-010092-uftc8inx 11760 24 P p NN cord-010092-uftc8inx 11760 25 < < XX cord-010092-uftc8inx 11760 26 0.001 0.001 CD cord-010092-uftc8inx 11760 27 ) ) -RRB- cord-010092-uftc8inx 11760 28 and and CC cord-010092-uftc8inx 11760 29 an an DT cord-010092-uftc8inx 11760 30 almost almost RB cord-010092-uftc8inx 11760 31 doubled double VBN cord-010092-uftc8inx 11760 32 rate rate NN cord-010092-uftc8inx 11760 33 of of IN cord-010092-uftc8inx 11760 34 parasitic parasitic JJ cord-010092-uftc8inx 11760 35 infections infection NNS cord-010092-uftc8inx 11760 36 ( ( -LRB- cord-010092-uftc8inx 11760 37 P p NN cord-010092-uftc8inx 11760 38 < < XX cord-010092-uftc8inx 11760 39 0.001 0.001 CD cord-010092-uftc8inx 11760 40 ) ) -RRB- cord-010092-uftc8inx 11760 41 . . . cord-010092-uftc8inx 11761 1 Compared compare VBN cord-010092-uftc8inx 11761 2 to to IN cord-010092-uftc8inx 11761 3 the the DT cord-010092-uftc8inx 11761 4 earlier early JJR cord-010092-uftc8inx 11761 5 period period NN cord-010092-uftc8inx 11761 6 , , , cord-010092-uftc8inx 11761 7 there there EX cord-010092-uftc8inx 11761 8 were be VBD cord-010092-uftc8inx 11761 9 many many JJ cord-010092-uftc8inx 11761 10 fewer few JJR cord-010092-uftc8inx 11761 11 HBV HBV NNP cord-010092-uftc8inx 11761 12 infections infection NNS cord-010092-uftc8inx 11761 13 ( ( -LRB- cord-010092-uftc8inx 11761 14 17 17 CD cord-010092-uftc8inx 11761 15 vs vs IN cord-010092-uftc8inx 11761 16 160 160 CD cord-010092-uftc8inx 11761 17 ) ) -RRB- cord-010092-uftc8inx 11761 18 and and CC cord-010092-uftc8inx 11761 19 many many JJ cord-010092-uftc8inx 11761 20 more more JJR cord-010092-uftc8inx 11761 21 HEV hev NN cord-010092-uftc8inx 11761 22 . . . cord-010092-uftc8inx 11762 1 A a DT cord-010092-uftc8inx 11762 2 similar similar JJ cord-010092-uftc8inx 11762 3 reduction reduction NN cord-010092-uftc8inx 11762 4 in in IN cord-010092-uftc8inx 11762 5 the the DT cord-010092-uftc8inx 11762 6 rate rate NN cord-010092-uftc8inx 11762 7 of of IN cord-010092-uftc8inx 11762 8 HCV HCV NNP cord-010092-uftc8inx 11762 9 and and CC cord-010092-uftc8inx 11762 10 HIV HIV NNP cord-010092-uftc8inx 11762 11 was be VBD cord-010092-uftc8inx 11762 12 observed observe VBN cord-010092-uftc8inx 11762 13 in in IN cord-010092-uftc8inx 11762 14 2013 2013 CD cord-010092-uftc8inx 11762 15 - - SYM cord-010092-uftc8inx 11762 16 2016 2016 CD cord-010092-uftc8inx 11762 17 in in IN cord-010092-uftc8inx 11762 18 comparison comparison NN cord-010092-uftc8inx 11762 19 with with IN cord-010092-uftc8inx 11762 20 previous previous JJ cord-010092-uftc8inx 11762 21 years year NNS cord-010092-uftc8inx 11762 22 . . . cord-010092-uftc8inx 11763 1 This this DT cord-010092-uftc8inx 11763 2 may may MD cord-010092-uftc8inx 11763 3 be be VB cord-010092-uftc8inx 11763 4 explained explain VBN cord-010092-uftc8inx 11763 5 by by IN cord-010092-uftc8inx 11763 6 the the DT cord-010092-uftc8inx 11763 7 fact fact NN cord-010092-uftc8inx 11763 8 that that IN cord-010092-uftc8inx 11763 9 NAT NAT NNP cord-010092-uftc8inx 11763 10 testing testing NN cord-010092-uftc8inx 11763 11 for for IN cord-010092-uftc8inx 11763 12 HCV HCV NNP cord-010092-uftc8inx 11763 13 / / SYM cord-010092-uftc8inx 11763 14 HIV HIV NNP cord-010092-uftc8inx 11763 15 / / SYM cord-010092-uftc8inx 11763 16 HBV HBV NNP cord-010092-uftc8inx 11763 17 has have VBZ cord-010092-uftc8inx 11763 18 been be VBN cord-010092-uftc8inx 11763 19 implemented implement VBN cord-010092-uftc8inx 11763 20 in in IN cord-010092-uftc8inx 11763 21 many many JJ cord-010092-uftc8inx 11763 22 countries country NNS cord-010092-uftc8inx 11763 23 in in IN cord-010092-uftc8inx 11763 24 the the DT cord-010092-uftc8inx 11763 25 last last JJ cord-010092-uftc8inx 11763 26 decade decade NN cord-010092-uftc8inx 11763 27 . . . cord-010092-uftc8inx 11764 1 Summary Summary NNP cord-010092-uftc8inx 11764 2 / / SYM cord-010092-uftc8inx 11764 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 11764 4 : : : cord-010092-uftc8inx 11765 1 The the DT cord-010092-uftc8inx 11765 2 infectious infectious JJ cord-010092-uftc8inx 11765 3 risk risk NN cord-010092-uftc8inx 11765 4 of of IN cord-010092-uftc8inx 11765 5 transfusion transfusion NN cord-010092-uftc8inx 11765 6 overall overall NN cord-010092-uftc8inx 11765 7 remains remain VBZ cord-010092-uftc8inx 11765 8 very very RB cord-010092-uftc8inx 11765 9 low low JJ cord-010092-uftc8inx 11765 10 . . . cord-010092-uftc8inx 11766 1 The the DT cord-010092-uftc8inx 11766 2 rate rate NN cord-010092-uftc8inx 11766 3 of of IN cord-010092-uftc8inx 11766 4 bacterial bacterial JJ cord-010092-uftc8inx 11766 5 cases case NNS cord-010092-uftc8inx 11766 6 has have VBZ cord-010092-uftc8inx 11766 7 increased increase VBN cord-010092-uftc8inx 11766 8 and and CC cord-010092-uftc8inx 11766 9 among among IN cord-010092-uftc8inx 11766 10 other other JJ cord-010092-uftc8inx 11766 11 viral viral NN cord-010092-uftc8inx 11766 12 sTTIs sTTIs NFP cord-010092-uftc8inx 11766 13 the the DT cord-010092-uftc8inx 11766 14 frequency frequency NN cord-010092-uftc8inx 11766 15 of of IN cord-010092-uftc8inx 11766 16 HEV HEV NNP cord-010092-uftc8inx 11766 17 is be VBZ cord-010092-uftc8inx 11766 18 increasing increase VBG cord-010092-uftc8inx 11766 19 . . . cord-010092-uftc8inx 11767 1 The the DT cord-010092-uftc8inx 11767 2 mortality mortality NN cord-010092-uftc8inx 11767 3 of of IN cord-010092-uftc8inx 11767 4 transfusion transfusion NN cord-010092-uftc8inx 11767 5 due due IN cord-010092-uftc8inx 11767 6 to to IN cord-010092-uftc8inx 11767 7 sTTIs sTTIs NNP cord-010092-uftc8inx 11767 8 is be VBZ cord-010092-uftc8inx 11767 9 lower low JJR cord-010092-uftc8inx 11767 10 than than IN cord-010092-uftc8inx 11767 11 in in IN cord-010092-uftc8inx 11767 12 the the DT cord-010092-uftc8inx 11767 13 previous previous JJ cord-010092-uftc8inx 11767 14 period period NN cord-010092-uftc8inx 11767 15 of of IN cord-010092-uftc8inx 11767 16 surveillance surveillance NN cord-010092-uftc8inx 11767 17 . . . cord-010092-uftc8inx 11768 1 Abstract Abstract NNP cord-010092-uftc8inx 11768 2 withdrawn withdraw VBN cord-010092-uftc8inx 11768 3 . . . cord-010092-uftc8inx 11769 1 Background background NN cord-010092-uftc8inx 11769 2 : : : cord-010092-uftc8inx 11770 1 One one CD cord-010092-uftc8inx 11770 2 of of IN cord-010092-uftc8inx 11770 3 the the DT cord-010092-uftc8inx 11770 4 main main JJ cord-010092-uftc8inx 11770 5 aspects aspect NNS cord-010092-uftc8inx 11770 6 of of IN cord-010092-uftc8inx 11770 7 haemovigilance haemovigilance NN cord-010092-uftc8inx 11770 8 system system NN cord-010092-uftc8inx 11770 9 in in IN cord-010092-uftc8inx 11770 10 hospitals hospital NNS cord-010092-uftc8inx 11770 11 is be VBZ cord-010092-uftc8inx 11770 12 following follow VBG cord-010092-uftc8inx 11770 13 of of IN cord-010092-uftc8inx 11770 14 adverse adverse JJ cord-010092-uftc8inx 11770 15 events event NNS cord-010092-uftc8inx 11770 16 and and CC cord-010092-uftc8inx 11770 17 reactions reaction NNS cord-010092-uftc8inx 11770 18 related relate VBN cord-010092-uftc8inx 11770 19 to to IN cord-010092-uftc8inx 11770 20 blood blood NN cord-010092-uftc8inx 11770 21 transfusions transfusion NNS cord-010092-uftc8inx 11770 22 . . . cord-010092-uftc8inx 11771 1 Aims aim VBZ cord-010092-uftc8inx 11771 2 : : : cord-010092-uftc8inx 11771 3 It -PRON- PRP cord-010092-uftc8inx 11771 4 was be VBD cord-010092-uftc8inx 11771 5 intended intend VBN cord-010092-uftc8inx 11771 6 to to TO cord-010092-uftc8inx 11771 7 analyse analyse VB cord-010092-uftc8inx 11771 8 the the DT cord-010092-uftc8inx 11771 9 adverse adverse JJ cord-010092-uftc8inx 11771 10 reactions reaction NNS cord-010092-uftc8inx 11771 11 related relate VBN cord-010092-uftc8inx 11771 12 to to IN cord-010092-uftc8inx 11771 13 transfusion transfusion NN cord-010092-uftc8inx 11771 14 of of IN cord-010092-uftc8inx 11771 15 blood blood NN cord-010092-uftc8inx 11771 16 components component NNS cord-010092-uftc8inx 11771 17 in in IN cord-010092-uftc8inx 11771 18 pediatric pediatric JJ cord-010092-uftc8inx 11771 19 patients patient NNS cord-010092-uftc8inx 11771 20 . . . cord-010092-uftc8inx 11772 1 Methods method NNS cord-010092-uftc8inx 11772 2 : : : cord-010092-uftc8inx 11772 3 Over over IN cord-010092-uftc8inx 11772 4 a a DT cord-010092-uftc8inx 11772 5 four four CD cord-010092-uftc8inx 11772 6 year year NN cord-010092-uftc8inx 11772 7 period period NN cord-010092-uftc8inx 11772 8 ( ( -LRB- cord-010092-uftc8inx 11772 9 January January NNP cord-010092-uftc8inx 11772 10 2015-December 2015-december CD cord-010092-uftc8inx 11772 11 2018 2018 CD cord-010092-uftc8inx 11772 12 ) ) -RRB- cord-010092-uftc8inx 11772 13 , , , cord-010092-uftc8inx 11772 14 the the DT cord-010092-uftc8inx 11772 15 haemovigilance haemovigilance NN cord-010092-uftc8inx 11772 16 records record NNS cord-010092-uftc8inx 11772 17 of of IN cord-010092-uftc8inx 11772 18 all all DT cord-010092-uftc8inx 11772 19 patients patient NNS cord-010092-uftc8inx 11772 20 receiving receive VBG cord-010092-uftc8inx 11772 21 blood blood NN cord-010092-uftc8inx 11772 22 transfusions transfusion NNS cord-010092-uftc8inx 11772 23 procedures procedure NNS cord-010092-uftc8inx 11772 24 were be VBD cord-010092-uftc8inx 11772 25 reviewed review VBN cord-010092-uftc8inx 11772 26 and and CC cord-010092-uftc8inx 11772 27 transfusion transfusion NN cord-010092-uftc8inx 11772 28 reactions reaction NNS cord-010092-uftc8inx 11772 29 were be VBD cord-010092-uftc8inx 11772 30 analysed analyse VBN cord-010092-uftc8inx 11772 31 . . . cord-010092-uftc8inx 11773 1 Statistical statistical JJ cord-010092-uftc8inx 11773 2 analysis analysis NN cord-010092-uftc8inx 11773 3 of of IN cord-010092-uftc8inx 11773 4 data datum NNS cord-010092-uftc8inx 11773 5 was be VBD cord-010092-uftc8inx 11773 6 performed perform VBN cord-010092-uftc8inx 11773 7 by by IN cord-010092-uftc8inx 11773 8 SPSS SPSS NNP cord-010092-uftc8inx 11773 9 software software NN cord-010092-uftc8inx 11773 10 ( ( -LRB- cord-010092-uftc8inx 11773 11 version version NN cord-010092-uftc8inx 11773 12 22.0 22.0 CD cord-010092-uftc8inx 11773 13 , , , cord-010092-uftc8inx 11773 14 SPSS SPSS NNP cord-010092-uftc8inx 11773 15 Inc. Inc. NNP cord-010092-uftc8inx 11773 16 , , , cord-010092-uftc8inx 11773 17 Chicago Chicago NNP cord-010092-uftc8inx 11773 18 , , , cord-010092-uftc8inx 11773 19 IL IL NNP cord-010092-uftc8inx 11773 20 , , , cord-010092-uftc8inx 11773 21 USA USA NNP cord-010092-uftc8inx 11773 22 ) ) -RRB- cord-010092-uftc8inx 11773 23 . . . cord-010092-uftc8inx 11774 1 Majority majority NN cord-010092-uftc8inx 11774 2 of of IN cord-010092-uftc8inx 11774 3 blood blood NN cord-010092-uftc8inx 11774 4 components component NNS cord-010092-uftc8inx 11774 5 were be VBD cord-010092-uftc8inx 11774 6 provided provide VBN cord-010092-uftc8inx 11774 7 by by IN cord-010092-uftc8inx 11774 8 regional regional JJ cord-010092-uftc8inx 11774 9 blood blood NN cord-010092-uftc8inx 11774 10 center center NN cord-010092-uftc8inx 11774 11 organized organize VBN cord-010092-uftc8inx 11774 12 by by IN cord-010092-uftc8inx 11774 13 national national JJ cord-010092-uftc8inx 11774 14 Red Red NNP cord-010092-uftc8inx 11774 15 Crescent Crescent NNP cord-010092-uftc8inx 11774 16 Society Society NNP cord-010092-uftc8inx 11774 17 . . . cord-010092-uftc8inx 11775 1 But but CC cord-010092-uftc8inx 11775 2 granulocytes granulocyte NNS cord-010092-uftc8inx 11775 3 collected collect VBN cord-010092-uftc8inx 11775 4 by by IN cord-010092-uftc8inx 11775 5 apheresis apheresis NN cord-010092-uftc8inx 11775 6 after after IN cord-010092-uftc8inx 11775 7 donor donor NN cord-010092-uftc8inx 11775 8 mobilization mobilization NN cord-010092-uftc8inx 11775 9 and and CC cord-010092-uftc8inx 11775 10 reconstituted reconstitute VBD cord-010092-uftc8inx 11775 11 whole whole JJ cord-010092-uftc8inx 11775 12 blood blood NN cord-010092-uftc8inx 11775 13 for for IN cord-010092-uftc8inx 11775 14 exchange exchange NN cord-010092-uftc8inx 11775 15 transfusions transfusion NNS cord-010092-uftc8inx 11775 16 were be VBD cord-010092-uftc8inx 11775 17 prepared prepare VBN cord-010092-uftc8inx 11775 18 in in IN cord-010092-uftc8inx 11775 19 the the DT cord-010092-uftc8inx 11775 20 transfusion transfusion NN cord-010092-uftc8inx 11775 21 center center NN cord-010092-uftc8inx 11775 22 of of IN cord-010092-uftc8inx 11775 23 the the DT cord-010092-uftc8inx 11775 24 hospital hospital NN cord-010092-uftc8inx 11775 25 . . . cord-010092-uftc8inx 11776 1 Results result NNS cord-010092-uftc8inx 11776 2 : : : cord-010092-uftc8inx 11777 1 The the DT cord-010092-uftc8inx 11777 2 median median JJ cord-010092-uftc8inx 11777 3 age age NN cord-010092-uftc8inx 11777 4 of of IN cord-010092-uftc8inx 11777 5 patients patient NNS cord-010092-uftc8inx 11777 6 who who WP cord-010092-uftc8inx 11777 7 developed develop VBD cord-010092-uftc8inx 11777 8 transfusion transfusion NN cord-010092-uftc8inx 11777 9 reactions reaction NNS cord-010092-uftc8inx 11777 10 was be VBD cord-010092-uftc8inx 11777 11 72 72 CD cord-010092-uftc8inx 11777 12 months month NNS cord-010092-uftc8inx 11777 13 ( ( -LRB- cord-010092-uftc8inx 11778 1 interquantile interquantile NNP cord-010092-uftc8inx 11778 2 range range NNP cord-010092-uftc8inx 11778 3 - - HYPH cord-010092-uftc8inx 11778 4 IQR IQR NNP cord-010092-uftc8inx 11778 5 108 108 CD cord-010092-uftc8inx 11778 6 ) ) -RRB- cord-010092-uftc8inx 11778 7 . . . cord-010092-uftc8inx 11779 1 The the DT cord-010092-uftc8inx 11779 2 median median NN cord-010092-uftc8inx 11779 3 for for IN cord-010092-uftc8inx 11779 4 the the DT cord-010092-uftc8inx 11779 5 numbers number NNS cord-010092-uftc8inx 11779 6 of of IN cord-010092-uftc8inx 11779 7 individual individual JJ cord-010092-uftc8inx 11779 8 transfusions transfusion NNS cord-010092-uftc8inx 11779 9 in in IN cord-010092-uftc8inx 11779 10 children child NNS cord-010092-uftc8inx 11779 11 in in IN cord-010092-uftc8inx 11779 12 a a DT cord-010092-uftc8inx 11779 13 year year NN cord-010092-uftc8inx 11779 14 was be VBD cord-010092-uftc8inx 11779 15 12 12 CD cord-010092-uftc8inx 11780 1 ( ( -LRB- cord-010092-uftc8inx 11780 2 IQR IQR NNP cord-010092-uftc8inx 11780 3 17 17 CD cord-010092-uftc8inx 11780 4 ) ) -RRB- cord-010092-uftc8inx 11780 5 . . . cord-010092-uftc8inx 11781 1 The the DT cord-010092-uftc8inx 11781 2 median median NN cord-010092-uftc8inx 11781 3 for for IN cord-010092-uftc8inx 11781 4 the the DT cord-010092-uftc8inx 11781 5 numbers number NNS cord-010092-uftc8inx 11781 6 of of IN cord-010092-uftc8inx 11781 7 blood blood NN cord-010092-uftc8inx 11781 8 components component NNS cord-010092-uftc8inx 11781 9 individually individually RB cord-010092-uftc8inx 11781 10 transfused transfuse VBN cord-010092-uftc8inx 11781 11 to to IN cord-010092-uftc8inx 11781 12 patients patient NNS cord-010092-uftc8inx 11781 13 was be VBD cord-010092-uftc8inx 11781 14 18 18 CD cord-010092-uftc8inx 11782 1 ( ( -LRB- cord-010092-uftc8inx 11782 2 IQR IQR NNP cord-010092-uftc8inx 11782 3 24 24 CD cord-010092-uftc8inx 11782 4 ) ) -RRB- cord-010092-uftc8inx 11782 5 . . . cord-010092-uftc8inx 11783 1 patients patient NNS cord-010092-uftc8inx 11783 2 , , , cord-010092-uftc8inx 11783 3 anaphylactic anaphylactic JJ cord-010092-uftc8inx 11783 4 transfusion transfusion NN cord-010092-uftc8inx 11783 5 reactions reaction NNS cord-010092-uftc8inx 11783 6 in in IN cord-010092-uftc8inx 11783 7 4 4 CD cord-010092-uftc8inx 11783 8 patients patient NNS cord-010092-uftc8inx 11783 9 and and CC cord-010092-uftc8inx 11783 10 transfusion transfusion NN cord-010092-uftc8inx 11783 11 - - HYPH cord-010092-uftc8inx 11783 12 related relate VBN cord-010092-uftc8inx 11783 13 lung lung NN cord-010092-uftc8inx 11783 14 injury injury NN cord-010092-uftc8inx 11783 15 ( ( -LRB- cord-010092-uftc8inx 11783 16 TRALI TRALI NNP cord-010092-uftc8inx 11783 17 ) ) -RRB- cord-010092-uftc8inx 11783 18 in in IN cord-010092-uftc8inx 11783 19 a a DT cord-010092-uftc8inx 11783 20 patient patient NN cord-010092-uftc8inx 11783 21 . . . cord-010092-uftc8inx 11784 1 The the DT cord-010092-uftc8inx 11784 2 overall overall JJ cord-010092-uftc8inx 11784 3 incidence incidence NN cord-010092-uftc8inx 11784 4 of of IN cord-010092-uftc8inx 11784 5 transfusion transfusion NN cord-010092-uftc8inx 11784 6 reactions reaction NNS cord-010092-uftc8inx 11784 7 was be VBD cord-010092-uftc8inx 11784 8 estimated estimate VBN cord-010092-uftc8inx 11784 9 at at IN cord-010092-uftc8inx 11784 10 a a DT cord-010092-uftc8inx 11784 11 rate rate NN cord-010092-uftc8inx 11784 12 of of IN cord-010092-uftc8inx 11784 13 2.7 2.7 CD cord-010092-uftc8inx 11784 14 per per IN cord-010092-uftc8inx 11784 15 100000 100000 CD cord-010092-uftc8inx 11784 16 units unit NNS cord-010092-uftc8inx 11784 17 . . . cord-010092-uftc8inx 11785 1 Summary Summary NNP cord-010092-uftc8inx 11785 2 / / SYM cord-010092-uftc8inx 11785 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 11785 4 : : : cord-010092-uftc8inx 11786 1 It -PRON- PRP cord-010092-uftc8inx 11786 2 was be VBD cord-010092-uftc8inx 11786 3 reported report VBN cord-010092-uftc8inx 11786 4 that that IN cord-010092-uftc8inx 11786 5 adverse adverse JJ cord-010092-uftc8inx 11786 6 effects effect NNS cord-010092-uftc8inx 11786 7 related relate VBN cord-010092-uftc8inx 11786 8 to to IN cord-010092-uftc8inx 11786 9 blood blood NN cord-010092-uftc8inx 11786 10 transfusion transfusion NN cord-010092-uftc8inx 11786 11 , , , cord-010092-uftc8inx 11786 12 especially especially RB cord-010092-uftc8inx 11786 13 allergic allergic JJ cord-010092-uftc8inx 11786 14 reactions reaction NNS cord-010092-uftc8inx 11786 15 and and CC cord-010092-uftc8inx 11786 16 FNHTRs fnhtr NNS cord-010092-uftc8inx 11786 17 are be VBP cord-010092-uftc8inx 11786 18 common common JJ cord-010092-uftc8inx 11786 19 in in IN cord-010092-uftc8inx 11786 20 pediatric pediatric JJ cord-010092-uftc8inx 11786 21 patients patient NNS cord-010092-uftc8inx 11786 22 than than IN cord-010092-uftc8inx 11786 23 adults adult NNS cord-010092-uftc8inx 11786 24 . . . cord-010092-uftc8inx 11787 1 In in IN cord-010092-uftc8inx 11787 2 a a DT cord-010092-uftc8inx 11787 3 multinational multinational JJ cord-010092-uftc8inx 11787 4 study study NN cord-010092-uftc8inx 11787 5 concerned concern VBN cord-010092-uftc8inx 11787 6 about about IN cord-010092-uftc8inx 11787 7 the the DT cord-010092-uftc8inx 11787 8 transfusion transfusion NN cord-010092-uftc8inx 11787 9 reactions reaction NNS cord-010092-uftc8inx 11787 10 related relate VBN cord-010092-uftc8inx 11787 11 with with IN cord-010092-uftc8inx 11787 12 red red JJ cord-010092-uftc8inx 11787 13 cell cell NN cord-010092-uftc8inx 11787 14 concentrates concentrate VBZ cord-010092-uftc8inx 11787 15 , , , cord-010092-uftc8inx 11787 16 allergic allergic JJ cord-010092-uftc8inx 11787 17 transfusion transfusion NN cord-010092-uftc8inx 11787 18 reactions reaction NNS cord-010092-uftc8inx 11787 19 and and CC cord-010092-uftc8inx 11787 20 FNHTRs fnhtr NNS cord-010092-uftc8inx 11787 21 were be VBD cord-010092-uftc8inx 11787 22 reported report VBN cord-010092-uftc8inx 11787 23 at at IN cord-010092-uftc8inx 11787 24 a a DT cord-010092-uftc8inx 11787 25 rate rate NN cord-010092-uftc8inx 11787 26 of of IN cord-010092-uftc8inx 11787 27 11 11 CD cord-010092-uftc8inx 11787 28 and and CC cord-010092-uftc8inx 11787 29 in in IN cord-010092-uftc8inx 11787 30 100000 100000 CD cord-010092-uftc8inx 11787 31 units unit NNS cord-010092-uftc8inx 11787 32 and and CC cord-010092-uftc8inx 11787 33 26 26 CD cord-010092-uftc8inx 11787 34 in in IN cord-010092-uftc8inx 11787 35 100000 100000 CD cord-010092-uftc8inx 11787 36 units unit NNS cord-010092-uftc8inx 11787 37 , , , cord-010092-uftc8inx 11787 38 respectively respectively RB cord-010092-uftc8inx 11787 39 . . . cord-010092-uftc8inx 11788 1 While while IN cord-010092-uftc8inx 11788 2 the the DT cord-010092-uftc8inx 11788 3 incidence incidence NN cord-010092-uftc8inx 11788 4 of of IN cord-010092-uftc8inx 11788 5 transfusion transfusion NN cord-010092-uftc8inx 11788 6 reactions reaction NNS cord-010092-uftc8inx 11788 7 in in IN cord-010092-uftc8inx 11788 8 children child NNS cord-010092-uftc8inx 11788 9 was be VBD cord-010092-uftc8inx 11788 10 found find VBN cord-010092-uftc8inx 11788 11 0.62 0.62 CD cord-010092-uftc8inx 11788 12 % % NN cord-010092-uftc8inx 11788 13 in in IN cord-010092-uftc8inx 11788 14 a a DT cord-010092-uftc8inx 11788 15 study study NN cord-010092-uftc8inx 11788 16 from from IN cord-010092-uftc8inx 11788 17 the the DT cord-010092-uftc8inx 11788 18 U.S.A. U.S.A. NNP cord-010092-uftc8inx 11788 19 , , , cord-010092-uftc8inx 11788 20 the the DT cord-010092-uftc8inx 11788 21 overall overall JJ cord-010092-uftc8inx 11788 22 incidence incidence NN cord-010092-uftc8inx 11788 23 of of IN cord-010092-uftc8inx 11788 24 transfusion transfusion NN cord-010092-uftc8inx 11788 25 reactions reaction NNS cord-010092-uftc8inx 11788 26 in in IN cord-010092-uftc8inx 11788 27 our -PRON- PRP$ cord-010092-uftc8inx 11788 28 study study NN cord-010092-uftc8inx 11788 29 which which WDT cord-010092-uftc8inx 11788 30 was be VBD cord-010092-uftc8inx 11788 31 estimated estimate VBN cord-010092-uftc8inx 11788 32 at at IN cord-010092-uftc8inx 11788 33 a a DT cord-010092-uftc8inx 11788 34 rate rate NN cord-010092-uftc8inx 11788 35 of of IN cord-010092-uftc8inx 11788 36 2.7 2.7 CD cord-010092-uftc8inx 11788 37 per per IN cord-010092-uftc8inx 11788 38 100000 100000 CD cord-010092-uftc8inx 11788 39 units unit NNS cord-010092-uftc8inx 11788 40 represents represent VBZ cord-010092-uftc8inx 11788 41 a a DT cord-010092-uftc8inx 11788 42 lower low JJR cord-010092-uftc8inx 11788 43 rate rate NN cord-010092-uftc8inx 11788 44 . . . cord-010092-uftc8inx 11789 1 Hospital Hospital NNP cord-010092-uftc8inx 11789 2 Gran Gran NNP cord-010092-uftc8inx 11789 3 Canaria Canaria NNP cord-010092-uftc8inx 11790 1 Dr. Dr. NNP cord-010092-uftc8inx 11790 2 Negr Negr NNP cord-010092-uftc8inx 11790 3 ın ın NNP cord-010092-uftc8inx 11790 4 , , , cord-010092-uftc8inx 11790 5 Gran Gran NNP cord-010092-uftc8inx 11790 6 Canaria Canaria NNP cord-010092-uftc8inx 11790 7 6 6 CD cord-010092-uftc8inx 11790 8 Hospital Hospital NNP cord-010092-uftc8inx 11790 9 General General NNP cord-010092-uftc8inx 11790 10 Universitario Universitario NNP cord-010092-uftc8inx 11790 11 , , , cord-010092-uftc8inx 11790 12 Ciudad Ciudad NNP cord-010092-uftc8inx 11790 13 Real Real NNP cord-010092-uftc8inx 11790 14 , , , cord-010092-uftc8inx 11790 15 Spain Spain NNP cord-010092-uftc8inx 11790 16 7 7 CD cord-010092-uftc8inx 11790 17 Hospital Hospital NNP cord-010092-uftc8inx 11790 18 Nostra Nostra NNP cord-010092-uftc8inx 11790 19 Senior Senior NNP cord-010092-uftc8inx 11790 20 de de IN cord-010092-uftc8inx 11790 21 Meritxell Meritxell NNP cord-010092-uftc8inx 11790 22 , , , cord-010092-uftc8inx 11790 23 Andorra Andorra NNP cord-010092-uftc8inx 11790 24 , , , cord-010092-uftc8inx 11790 25 Andorra Andorra NNP cord-010092-uftc8inx 11790 26 8 8 CD cord-010092-uftc8inx 11790 27 Banco Banco NNP cord-010092-uftc8inx 11790 28 Sangre Sangre NNP cord-010092-uftc8inx 11790 29 y y NNP cord-010092-uftc8inx 11790 30 Tejidos Tejidos NNP cord-010092-uftc8inx 11790 31 , , , cord-010092-uftc8inx 11790 32 Santander Santander NNP cord-010092-uftc8inx 11790 33 9 9 CD cord-010092-uftc8inx 11790 34 Banc Banc NNP cord-010092-uftc8inx 11790 35 de de NNP cord-010092-uftc8inx 11790 36 Sang Sang NNP cord-010092-uftc8inx 11791 1 i i PRP cord-010092-uftc8inx 11791 2 Teixits Teixits NNP cord-010092-uftc8inx 11791 3 , , , cord-010092-uftc8inx 11791 4 Barcelona Barcelona NNP cord-010092-uftc8inx 11791 5 , , , cord-010092-uftc8inx 11792 1 Spain Spain NNP cord-010092-uftc8inx 11792 2 10 10 CD cord-010092-uftc8inx 11792 3 Fundaci Fundaci NNP cord-010092-uftc8inx 11792 4 on on IN cord-010092-uftc8inx 11792 5 Hematol Hematol NNP cord-010092-uftc8inx 11792 6 ogica ogica NNP cord-010092-uftc8inx 11792 7 Colombia Colombia NNP cord-010092-uftc8inx 11792 8 , , , cord-010092-uftc8inx 11793 1 Bogot Bogot NNP cord-010092-uftc8inx 11793 2 a a DT cord-010092-uftc8inx 11794 1 , , , cord-010092-uftc8inx 11794 2 Colombia Colombia NNP cord-010092-uftc8inx 11794 3 11 11 CD cord-010092-uftc8inx 11794 4 Centro Centro NNP cord-010092-uftc8inx 11794 5 Regional Regional NNP cord-010092-uftc8inx 11794 6 de de IN cord-010092-uftc8inx 11794 7 Transfusi Transfusi NNP cord-010092-uftc8inx 11794 8 on on IN cord-010092-uftc8inx 11794 9 de de NNP cord-010092-uftc8inx 11794 10 Almer Almer NNP cord-010092-uftc8inx 11794 11 ıa ıa NNP cord-010092-uftc8inx 11794 12 , , , cord-010092-uftc8inx 11794 13 Almeria Almeria NNP cord-010092-uftc8inx 11794 14 12 12 CD cord-010092-uftc8inx 11794 15 Complejo Complejo NNP cord-010092-uftc8inx 11794 16 Hospitalario Hospitalario NNP cord-010092-uftc8inx 11794 17 de de NNP cord-010092-uftc8inx 11794 18 Navarra Navarra NNP cord-010092-uftc8inx 11794 19 , , , cord-010092-uftc8inx 11794 20 Pamplona Pamplona NNP cord-010092-uftc8inx 11794 21 13 13 CD cord-010092-uftc8inx 11794 22 Fundaci Fundaci NNP cord-010092-uftc8inx 11794 23 on on IN cord-010092-uftc8inx 11794 24 Banc Banc NNP cord-010092-uftc8inx 11794 25 de de NNP cord-010092-uftc8inx 11794 26 Sang Sang NNP cord-010092-uftc8inx 11795 1 i i PRP cord-010092-uftc8inx 11796 1 Teixits Teixits NNP cord-010092-uftc8inx 11796 2 Illes Illes NNP cord-010092-uftc8inx 11796 3 Balears Balears NNP cord-010092-uftc8inx 11796 4 , , , cord-010092-uftc8inx 11796 5 Palma Palma NNP cord-010092-uftc8inx 11796 6 de de NNP cord-010092-uftc8inx 11796 7 Mallorca Mallorca NNP cord-010092-uftc8inx 11796 8 14 14 CD cord-010092-uftc8inx 11796 9 Hospital Hospital NNP cord-010092-uftc8inx 11796 10 de de NNP cord-010092-uftc8inx 11796 11 Cabueñes Cabueñes NNP cord-010092-uftc8inx 11796 12 , , , cord-010092-uftc8inx 11796 13 Gij Gij NNP cord-010092-uftc8inx 11796 14 on on RB cord-010092-uftc8inx 11796 15 , , , cord-010092-uftc8inx 11796 16 Spain Spain NNP cord-010092-uftc8inx 11796 17 Background Background NNP cord-010092-uftc8inx 11797 1 : : : cord-010092-uftc8inx 11797 2 Root root NN cord-010092-uftc8inx 11797 3 analysis analysis NN cord-010092-uftc8inx 11797 4 cause cause NN cord-010092-uftc8inx 11797 5 is be VBZ cord-010092-uftc8inx 11797 6 defined define VBN cord-010092-uftc8inx 11797 7 as as IN cord-010092-uftc8inx 11797 8 the the DT cord-010092-uftc8inx 11797 9 cause cause NN cord-010092-uftc8inx 11797 10 of of IN cord-010092-uftc8inx 11797 11 an an DT cord-010092-uftc8inx 11797 12 error error NN cord-010092-uftc8inx 11797 13 that that IN cord-010092-uftc8inx 11797 14 , , , cord-010092-uftc8inx 11797 15 if if IN cord-010092-uftc8inx 11797 16 it -PRON- PRP cord-010092-uftc8inx 11797 17 is be VBZ cord-010092-uftc8inx 11797 18 treated treat VBN cord-010092-uftc8inx 11797 19 , , , cord-010092-uftc8inx 11797 20 eliminates eliminate VBZ cord-010092-uftc8inx 11797 21 the the DT cord-010092-uftc8inx 11797 22 repetition repetition NN cord-010092-uftc8inx 11797 23 of of IN cord-010092-uftc8inx 11797 24 the the DT cord-010092-uftc8inx 11797 25 error error NN cord-010092-uftc8inx 11797 26 Aims aim VBZ cord-010092-uftc8inx 11797 27 : : : cord-010092-uftc8inx 11798 1 Describe describe VB cord-010092-uftc8inx 11798 2 types type NNS cord-010092-uftc8inx 11798 3 of of IN cord-010092-uftc8inx 11798 4 human human JJ cord-010092-uftc8inx 11798 5 and and CC cord-010092-uftc8inx 11798 6 latent latent JJ cord-010092-uftc8inx 11798 7 errors error NNS cord-010092-uftc8inx 11798 8 detected detect VBN cord-010092-uftc8inx 11798 9 by by IN cord-010092-uftc8inx 11798 10 a a DT cord-010092-uftc8inx 11798 11 work work NN cord-010092-uftc8inx 11798 12 group group NN cord-010092-uftc8inx 11798 13 in in IN cord-010092-uftc8inx 11798 14 the the DT cord-010092-uftc8inx 11798 15 root root NN cord-010092-uftc8inx 11798 16 analysis analysis NN cord-010092-uftc8inx 11798 17 cause cause NN cord-010092-uftc8inx 11798 18 of of IN cord-010092-uftc8inx 11798 19 transfusion transfusion NN cord-010092-uftc8inx 11798 20 incidents incident NNS cord-010092-uftc8inx 11798 21 , , , cord-010092-uftc8inx 11798 22 analyze analyze VB cord-010092-uftc8inx 11798 23 the the DT cord-010092-uftc8inx 11798 24 concordance concordance NN cord-010092-uftc8inx 11798 25 between between IN cord-010092-uftc8inx 11798 26 the the DT cord-010092-uftc8inx 11798 27 individual individual JJ cord-010092-uftc8inx 11798 28 responses response NNS cord-010092-uftc8inx 11798 29 of of IN cord-010092-uftc8inx 11798 30 the the DT cord-010092-uftc8inx 11798 31 members member NNS cord-010092-uftc8inx 11798 32 and and CC cord-010092-uftc8inx 11798 33 propose propose VB cord-010092-uftc8inx 11798 34 recommendations recommendation NNS cord-010092-uftc8inx 11798 35 in in IN cord-010092-uftc8inx 11798 36 order order NN cord-010092-uftc8inx 11798 37 to to TO cord-010092-uftc8inx 11798 38 improve improve VB cord-010092-uftc8inx 11798 39 transfusional transfusional JJ cord-010092-uftc8inx 11798 40 safety safety NN cord-010092-uftc8inx 11798 41 . . . cord-010092-uftc8inx 11799 1 Methods method NNS cord-010092-uftc8inx 11799 2 : : : cord-010092-uftc8inx 11799 3 In in IN cord-010092-uftc8inx 11799 4 2018 2018 CD cord-010092-uftc8inx 11799 5 fifteen fifteen CD cord-010092-uftc8inx 11799 6 participants participant NNS cord-010092-uftc8inx 11799 7 ( ( -LRB- cord-010092-uftc8inx 11799 8 nurses nurse NNS cord-010092-uftc8inx 11799 9 and and CC cord-010092-uftc8inx 11799 10 hematologists hematologist NNS cord-010092-uftc8inx 11799 11 dedicated dedicate VBN cord-010092-uftc8inx 11799 12 to to IN cord-010092-uftc8inx 11799 13 transfusion transfusion NN cord-010092-uftc8inx 11799 14 and and CC cord-010092-uftc8inx 11799 15 component component NN cord-010092-uftc8inx 11799 16 preparation preparation NN cord-010092-uftc8inx 11799 17 ) ) -RRB- cord-010092-uftc8inx 11799 18 studied study VBD cord-010092-uftc8inx 11799 19 some some DT cord-010092-uftc8inx 11799 20 incidents incident NNS cord-010092-uftc8inx 11799 21 of of IN cord-010092-uftc8inx 11799 22 administration administration NN cord-010092-uftc8inx 11799 23 of of IN cord-010092-uftc8inx 11799 24 nonirradiated nonirradiated NNP cord-010092-uftc8inx 11799 25 components components NNP cord-010092-uftc8inx 11799 26 and and CC cord-010092-uftc8inx 11799 27 tried try VBD cord-010092-uftc8inx 11799 28 to to TO cord-010092-uftc8inx 11799 29 approach approach VB cord-010092-uftc8inx 11799 30 the the DT cord-010092-uftc8inx 11799 31 root root NN cord-010092-uftc8inx 11799 32 causes cause NNS cord-010092-uftc8inx 11799 33 by by IN cord-010092-uftc8inx 11799 34 applying apply VBG cord-010092-uftc8inx 11799 35 the the DT cord-010092-uftc8inx 11799 36 classification classification NN cord-010092-uftc8inx 11799 37 of of IN cord-010092-uftc8inx 11799 38 errors error NNS cord-010092-uftc8inx 11799 39 in in IN cord-010092-uftc8inx 11799 40 MERS MERS NNP cord-010092-uftc8inx 11799 41 - - HYPH cord-010092-uftc8inx 11799 42 TM TM NNP cord-010092-uftc8inx 11799 43 Transfusion Transfusion NNP cord-010092-uftc8inx 11799 44 Medicine Medicine NNP cord-010092-uftc8inx 11799 45 . . . cord-010092-uftc8inx 11800 1 They -PRON- PRP cord-010092-uftc8inx 11800 2 transferred transfer VBD cord-010092-uftc8inx 11800 3 the the DT cord-010092-uftc8inx 11800 4 answers answer NNS cord-010092-uftc8inx 11800 5 to to IN cord-010092-uftc8inx 11800 6 a a DT cord-010092-uftc8inx 11800 7 questionnaire questionnaire NN cord-010092-uftc8inx 11800 8 ( ( -LRB- cord-010092-uftc8inx 11800 9 simple simple JJ cord-010092-uftc8inx 11800 10 or or CC cord-010092-uftc8inx 11800 11 chain chain NN cord-010092-uftc8inx 11800 12 error error NN cord-010092-uftc8inx 11800 13 , , , cord-010092-uftc8inx 11800 14 initial initial JJ cord-010092-uftc8inx 11800 15 process process NN cord-010092-uftc8inx 11800 16 affected affect VBN cord-010092-uftc8inx 11800 17 , , , cord-010092-uftc8inx 11800 18 human human JJ cord-010092-uftc8inx 11800 19 and and CC cord-010092-uftc8inx 11800 20 latent latent JJ cord-010092-uftc8inx 11800 21 errors error NNS cord-010092-uftc8inx 11800 22 and and CC cord-010092-uftc8inx 11800 23 measures measure NNS cord-010092-uftc8inx 11800 24 derived derive VBN cord-010092-uftc8inx 11800 25 from from IN cord-010092-uftc8inx 11800 26 the the DT cord-010092-uftc8inx 11800 27 analysis analysis NN cord-010092-uftc8inx 11800 28 to to TO cord-010092-uftc8inx 11800 29 correct correct VB cord-010092-uftc8inx 11800 30 the the DT cord-010092-uftc8inx 11800 31 errors error NNS cord-010092-uftc8inx 11800 32 ) ) -RRB- cord-010092-uftc8inx 11800 33 . . . cord-010092-uftc8inx 11801 1 The the DT cord-010092-uftc8inx 11801 2 communication communication NN cord-010092-uftc8inx 11801 3 was be VBD cord-010092-uftc8inx 11801 4 made make VBN cord-010092-uftc8inx 11801 5 by by IN cord-010092-uftc8inx 11801 6 mail mail NN cord-010092-uftc8inx 11801 7 and and CC cord-010092-uftc8inx 11801 8 by by IN cord-010092-uftc8inx 11801 9 the the DT cord-010092-uftc8inx 11801 10 Spanish Spanish NNP cord-010092-uftc8inx 11801 11 Transfusion Transfusion NNP cord-010092-uftc8inx 11801 12 Society Society NNP cord-010092-uftc8inx 11801 13 web web NN cord-010092-uftc8inx 11801 14 forum forum NN cord-010092-uftc8inx 11801 15 , , , cord-010092-uftc8inx 11801 16 which which WDT cord-010092-uftc8inx 11801 17 contained contain VBD cord-010092-uftc8inx 11801 18 the the DT cord-010092-uftc8inx 11801 19 consultation consultation NN cord-010092-uftc8inx 11801 20 documents document NNS cord-010092-uftc8inx 11801 21 . . . cord-010092-uftc8inx 11802 1 Data datum NNS cord-010092-uftc8inx 11802 2 and and CC cord-010092-uftc8inx 11802 3 percentages percentage NNS cord-010092-uftc8inx 11802 4 are be VBP cord-010092-uftc8inx 11802 5 exposed expose VBN cord-010092-uftc8inx 11802 6 for for IN cord-010092-uftc8inx 11802 7 each each DT cord-010092-uftc8inx 11802 8 type type NN cord-010092-uftc8inx 11802 9 of of IN cord-010092-uftc8inx 11802 10 error error NN cord-010092-uftc8inx 11802 11 and and CC cord-010092-uftc8inx 11802 12 the the DT cord-010092-uftc8inx 11802 13 answers answer NNS cord-010092-uftc8inx 11802 14 of of IN cord-010092-uftc8inx 11802 15 the the DT cord-010092-uftc8inx 11802 16 participants participant NNS cord-010092-uftc8inx 11802 17 are be VBP cord-010092-uftc8inx 11802 18 tabulated tabulate VBN cord-010092-uftc8inx 11802 19 . . . cord-010092-uftc8inx 11803 1 Results result NNS cord-010092-uftc8inx 11803 2 : : : cord-010092-uftc8inx 11803 3 Cases case NNS cord-010092-uftc8inx 11803 4 corresponded correspond VBD cord-010092-uftc8inx 11803 5 to to IN cord-010092-uftc8inx 11803 6 3 3 CD cord-010092-uftc8inx 11803 7 patients patient NNS cord-010092-uftc8inx 11803 8 . . . cord-010092-uftc8inx 11804 1 Two two CD cord-010092-uftc8inx 11804 2 patients patient NNS cord-010092-uftc8inx 11804 3 of of IN cord-010092-uftc8inx 11804 4 55 55 CD cord-010092-uftc8inx 11804 5 years year NNS cord-010092-uftc8inx 11804 6 of of IN cord-010092-uftc8inx 11804 7 age age NN cord-010092-uftc8inx 11804 8 diagnosed diagnose VBN cord-010092-uftc8inx 11804 9 of of IN cord-010092-uftc8inx 11804 10 acute acute JJ cord-010092-uftc8inx 11804 11 myeloblastic myeloblastic JJ cord-010092-uftc8inx 11804 12 leukemia leukemia NN cord-010092-uftc8inx 11804 13 ( ( -LRB- cord-010092-uftc8inx 11804 14 case case NN cord-010092-uftc8inx 11804 15 1 1 CD cord-010092-uftc8inx 11804 16 and and CC cord-010092-uftc8inx 11804 17 2 2 CD cord-010092-uftc8inx 11804 18 ) ) -RRB- cord-010092-uftc8inx 11804 19 and and CC cord-010092-uftc8inx 11804 20 chronic chronic JJ cord-010092-uftc8inx 11804 21 lymphatic lymphatic NN cord-010092-uftc8inx 11804 22 leukemia leukemia NN cord-010092-uftc8inx 11804 23 ( ( -LRB- cord-010092-uftc8inx 11804 24 case case NN cord-010092-uftc8inx 11804 25 3 3 CD cord-010092-uftc8inx 11804 26 ) ) -RRB- cord-010092-uftc8inx 11804 27 . . . cord-010092-uftc8inx 11805 1 In in IN cord-010092-uftc8inx 11805 2 one one CD cord-010092-uftc8inx 11805 3 case case NN cord-010092-uftc8inx 11805 4 , , , cord-010092-uftc8inx 11805 5 the the DT cord-010092-uftc8inx 11805 6 hematologist hematologist NN cord-010092-uftc8inx 11805 7 of of IN cord-010092-uftc8inx 11805 8 the the DT cord-010092-uftc8inx 11805 9 Transfusion Transfusion NNP cord-010092-uftc8inx 11805 10 Service Service NNP cord-010092-uftc8inx 11805 11 canceled cancel VBD cord-010092-uftc8inx 11805 12 an an DT cord-010092-uftc8inx 11805 13 irradiation irradiation NN cord-010092-uftc8inx 11805 14 prescription prescription NN cord-010092-uftc8inx 11805 15 ; ; : cord-010092-uftc8inx 11805 16 in in IN cord-010092-uftc8inx 11805 17 another another DT cord-010092-uftc8inx 11805 18 , , , cord-010092-uftc8inx 11805 19 a a DT cord-010092-uftc8inx 11805 20 patient patient NN cord-010092-uftc8inx 11805 21 with with IN cord-010092-uftc8inx 11805 22 fever fever NN cord-010092-uftc8inx 11805 23 was be VBD cord-010092-uftc8inx 11805 24 transfused transfuse VBN cord-010092-uftc8inx 11805 25 in in IN cord-010092-uftc8inx 11805 26 the the DT cord-010092-uftc8inx 11805 27 Emergency Emergency NNP cord-010092-uftc8inx 11805 28 Room Room NNP cord-010092-uftc8inx 11805 29 without without IN cord-010092-uftc8inx 11805 30 the the DT cord-010092-uftc8inx 11805 31 irradiation irradiation NN cord-010092-uftc8inx 11805 32 requirement requirement NN cord-010092-uftc8inx 11805 33 and and CC cord-010092-uftc8inx 11805 34 it -PRON- PRP cord-010092-uftc8inx 11805 35 was be VBD cord-010092-uftc8inx 11805 36 later later RB cord-010092-uftc8inx 11805 37 discovered discover VBN cord-010092-uftc8inx 11805 38 that that IN cord-010092-uftc8inx 11805 39 he -PRON- PRP cord-010092-uftc8inx 11805 40 had have VBD cord-010092-uftc8inx 11805 41 received receive VBN cord-010092-uftc8inx 11805 42 a a DT cord-010092-uftc8inx 11805 43 transplant transplant NN cord-010092-uftc8inx 11805 44 of of IN cord-010092-uftc8inx 11805 45 hemopoietic hemopoietic JJ cord-010092-uftc8inx 11805 46 progenitors progenitor NNS cord-010092-uftc8inx 11805 47 1 1 CD cord-010092-uftc8inx 11805 48 month month NN cord-010092-uftc8inx 11805 49 earlier early RBR cord-010092-uftc8inx 11805 50 ; ; . cord-010092-uftc8inx 11805 51 In in IN cord-010092-uftc8inx 11805 52 the the DT cord-010092-uftc8inx 11805 53 last last JJ cord-010092-uftc8inx 11805 54 case case NN cord-010092-uftc8inx 11805 55 , , , cord-010092-uftc8inx 11805 56 neither neither CC cord-010092-uftc8inx 11805 57 the the DT cord-010092-uftc8inx 11805 58 requesting request VBG cord-010092-uftc8inx 11805 59 doctor doctor NN cord-010092-uftc8inx 11805 60 nor nor CC cord-010092-uftc8inx 11805 61 the the DT cord-010092-uftc8inx 11805 62 laboratory laboratory NN cord-010092-uftc8inx 11805 63 technician technician NN cord-010092-uftc8inx 11805 64 nor nor CC cord-010092-uftc8inx 11805 65 the the DT cord-010092-uftc8inx 11805 66 following follow VBG cord-010092-uftc8inx 11805 67 doctor doctor NN cord-010092-uftc8inx 11805 68 ( ( -LRB- cord-010092-uftc8inx 11805 69 prescriber prescriber NN cord-010092-uftc8inx 11805 70 ) ) -RRB- cord-010092-uftc8inx 11805 71 detected detect VBD cord-010092-uftc8inx 11805 72 the the DT cord-010092-uftc8inx 11805 73 alerts alert NNS cord-010092-uftc8inx 11805 74 located locate VBN cord-010092-uftc8inx 11805 75 in in IN cord-010092-uftc8inx 11805 76 their -PRON- PRP$ cord-010092-uftc8inx 11805 77 respective respective JJ cord-010092-uftc8inx 11805 78 computer computer NN cord-010092-uftc8inx 11805 79 applications application NNS cord-010092-uftc8inx 11805 80 . . . cord-010092-uftc8inx 11806 1 In in IN cord-010092-uftc8inx 11806 2 all all DT cord-010092-uftc8inx 11806 3 3 3 CD cord-010092-uftc8inx 11806 4 cases case NNS cord-010092-uftc8inx 11806 5 , , , cord-010092-uftc8inx 11806 6 the the DT cord-010092-uftc8inx 11806 7 story story NN cord-010092-uftc8inx 11806 8 was be VBD cord-010092-uftc8inx 11806 9 judged judge VBN cord-010092-uftc8inx 11806 10 as as IN cord-010092-uftc8inx 11806 11 sufficient sufficient JJ cord-010092-uftc8inx 11806 12 for for IN cord-010092-uftc8inx 11806 13 analysis analysis NN cord-010092-uftc8inx 11806 14 . . . cord-010092-uftc8inx 11807 1 The the DT cord-010092-uftc8inx 11807 2 majority majority NN cord-010092-uftc8inx 11807 3 of of IN cord-010092-uftc8inx 11807 4 reviewers reviewer NNS cord-010092-uftc8inx 11807 5 ( ( -LRB- cord-010092-uftc8inx 11807 6 93 93 CD cord-010092-uftc8inx 11807 7 % % NN cord-010092-uftc8inx 11807 8 ) ) -RRB- cord-010092-uftc8inx 11807 9 diagnosed diagnose VBD cord-010092-uftc8inx 11807 10 a a DT cord-010092-uftc8inx 11807 11 chain chain NN cord-010092-uftc8inx 11807 12 of of IN cord-010092-uftc8inx 11807 13 errors error NNS cord-010092-uftc8inx 11807 14 . . . cord-010092-uftc8inx 11808 1 There there EX cord-010092-uftc8inx 11808 2 was be VBD cord-010092-uftc8inx 11808 3 agreement agreement NN cord-010092-uftc8inx 11808 4 of of IN cord-010092-uftc8inx 11808 5 95 95 CD cord-010092-uftc8inx 11808 6 % % NN cord-010092-uftc8inx 11808 7 with with IN cord-010092-uftc8inx 11808 8 respect respect NN cord-010092-uftc8inx 11808 9 to to IN cord-010092-uftc8inx 11808 10 the the DT cord-010092-uftc8inx 11808 11 initial initial JJ cord-010092-uftc8inx 11808 12 process process NN cord-010092-uftc8inx 11808 13 affected affect VBN cord-010092-uftc8inx 11808 14 . . . cord-010092-uftc8inx 11809 1 The the DT cord-010092-uftc8inx 11809 2 initial initial JJ cord-010092-uftc8inx 11809 3 error error NN cord-010092-uftc8inx 11809 4 was be VBD cord-010092-uftc8inx 11809 5 communication communication NN cord-010092-uftc8inx 11809 6 ( ( -LRB- cord-010092-uftc8inx 11809 7 42 42 CD cord-010092-uftc8inx 11809 8 % % NN cord-010092-uftc8inx 11809 9 ) ) -RRB- cord-010092-uftc8inx 11809 10 , , , cord-010092-uftc8inx 11809 11 monitoring monitoring NN cord-010092-uftc8inx 11809 12 ( ( -LRB- cord-010092-uftc8inx 11809 13 45 45 CD cord-010092-uftc8inx 11809 14 % % NN cord-010092-uftc8inx 11809 15 ) ) -RRB- cord-010092-uftc8inx 11809 16 and and CC cord-010092-uftc8inx 11809 17 compliance compliance NN cord-010092-uftc8inx 11809 18 ( ( -LRB- cord-010092-uftc8inx 11809 19 62 62 CD cord-010092-uftc8inx 11809 20 % % NN cord-010092-uftc8inx 11809 21 ) ) -RRB- cord-010092-uftc8inx 11809 22 , , , cord-010092-uftc8inx 11809 23 in in IN cord-010092-uftc8inx 11809 24 cases case NNS cord-010092-uftc8inx 11809 25 1 1 CD cord-010092-uftc8inx 11809 26 , , , cord-010092-uftc8inx 11809 27 2 2 CD cord-010092-uftc8inx 11809 28 , , , cord-010092-uftc8inx 11809 29 and and CC cord-010092-uftc8inx 11809 30 3 3 CD cord-010092-uftc8inx 11809 31 . . CD cord-010092-uftc8inx 11809 32 2 2 CD cord-010092-uftc8inx 11809 33 - - SYM cord-010092-uftc8inx 11809 34 3 3 CD cord-010092-uftc8inx 11809 35 human human JJ cord-010092-uftc8inx 11809 36 errors error NNS cord-010092-uftc8inx 11809 37 were be VBD cord-010092-uftc8inx 11809 38 detected detect VBN cord-010092-uftc8inx 11809 39 per per IN cord-010092-uftc8inx 11809 40 case case NN cord-010092-uftc8inx 11809 41 ( ( -LRB- cord-010092-uftc8inx 11809 42 average average NN cord-010092-uftc8inx 11809 43 : : : cord-010092-uftc8inx 11809 44 2.2 2.2 CD cord-010092-uftc8inx 11809 45 , , , cord-010092-uftc8inx 11809 46 2.7 2.7 CD cord-010092-uftc8inx 11809 47 and and CC cord-010092-uftc8inx 11809 48 2.4 2.4 CD cord-010092-uftc8inx 11809 49 errors error NNS cord-010092-uftc8inx 11809 50 respectively respectively RB cord-010092-uftc8inx 11809 51 ) ) -RRB- cord-010092-uftc8inx 11809 52 and and CC cord-010092-uftc8inx 11809 53 2 2 CD cord-010092-uftc8inx 11809 54 - - SYM cord-010092-uftc8inx 11809 55 3 3 CD cord-010092-uftc8inx 11809 56 latent latent JJ cord-010092-uftc8inx 11809 57 errors error NNS cord-010092-uftc8inx 11809 58 per per IN cord-010092-uftc8inx 11809 59 case case NN cord-010092-uftc8inx 11809 60 ( ( -LRB- cord-010092-uftc8inx 11809 61 average average NN cord-010092-uftc8inx 11809 62 : : : cord-010092-uftc8inx 11809 63 1.8 1.8 CD cord-010092-uftc8inx 11809 64 , , , cord-010092-uftc8inx 11809 65 2.7 2.7 CD cord-010092-uftc8inx 11809 66 and and CC cord-010092-uftc8inx 11809 67 2.1 2.1 CD cord-010092-uftc8inx 11809 68 , , , cord-010092-uftc8inx 11809 69 respectively respectively RB cord-010092-uftc8inx 11809 70 ) ) -RRB- cord-010092-uftc8inx 11809 71 . . . cord-010092-uftc8inx 11810 1 The the DT cord-010092-uftc8inx 11810 2 latent latent NN cord-010092-uftc8inx 11810 3 errors error NNS cord-010092-uftc8inx 11810 4 most most RBS cord-010092-uftc8inx 11810 5 punctuated punctuated JJ cord-010092-uftc8inx 11810 6 were be VBD cord-010092-uftc8inx 11810 7 : : : cord-010092-uftc8inx 11810 8 failures failure NNS cord-010092-uftc8inx 11810 9 in in IN cord-010092-uftc8inx 11810 10 the the DT cord-010092-uftc8inx 11810 11 quality quality NN cord-010092-uftc8inx 11810 12 of of IN cord-010092-uftc8inx 11810 13 the the DT cord-010092-uftc8inx 11810 14 protocols protocol NNS cord-010092-uftc8inx 11810 15 ( ( -LRB- cord-010092-uftc8inx 11810 16 24 24 CD cord-010092-uftc8inx 11810 17 % % NN cord-010092-uftc8inx 11810 18 ) ) -RRB- cord-010092-uftc8inx 11810 19 , , , cord-010092-uftc8inx 11810 20 in in IN cord-010092-uftc8inx 11810 21 the the DT cord-010092-uftc8inx 11810 22 transfer transfer NN cord-010092-uftc8inx 11810 23 of of IN cord-010092-uftc8inx 11810 24 important important JJ cord-010092-uftc8inx 11810 25 knowledge knowledge NN cord-010092-uftc8inx 11810 26 ( ( -LRB- cord-010092-uftc8inx 11810 27 22 22 CD cord-010092-uftc8inx 11810 28 % % NN cord-010092-uftc8inx 11810 29 ) ) -RRB- cord-010092-uftc8inx 11810 30 , , , cord-010092-uftc8inx 11810 31 in in IN cord-010092-uftc8inx 11810 32 the the DT cord-010092-uftc8inx 11810 33 available available JJ cord-010092-uftc8inx 11810 34 technology technology NN cord-010092-uftc8inx 11810 35 ( ( -LRB- cord-010092-uftc8inx 11810 36 21 21 CD cord-010092-uftc8inx 11810 37 % % NN cord-010092-uftc8inx 11810 38 ) ) -RRB- cord-010092-uftc8inx 11810 39 and and CC cord-010092-uftc8inx 11810 40 in in IN cord-010092-uftc8inx 11810 41 the the DT cord-010092-uftc8inx 11810 42 information information NN cord-010092-uftc8inx 11810 43 to to IN cord-010092-uftc8inx 11810 44 the the DT cord-010092-uftc8inx 11810 45 patient patient NN cord-010092-uftc8inx 11810 46 ( ( -LRB- cord-010092-uftc8inx 11810 47 10 10 CD cord-010092-uftc8inx 11810 48 % % NN cord-010092-uftc8inx 11810 49 ) ) -RRB- cord-010092-uftc8inx 11810 50 . . . cord-010092-uftc8inx 11811 1 All all PDT cord-010092-uftc8inx 11811 2 the the DT cord-010092-uftc8inx 11811 3 participants participant NNS cord-010092-uftc8inx 11811 4 contributed contribute VBD cord-010092-uftc8inx 11811 5 feasible feasible JJ cord-010092-uftc8inx 11811 6 measures measure NNS cord-010092-uftc8inx 11811 7 of of IN cord-010092-uftc8inx 11811 8 improvement improvement NN cord-010092-uftc8inx 11811 9 according accord VBG cord-010092-uftc8inx 11811 10 to to IN cord-010092-uftc8inx 11811 11 root root NN cord-010092-uftc8inx 11811 12 causes cause NNS cord-010092-uftc8inx 11811 13 : : : cord-010092-uftc8inx 11811 14 1 1 LS cord-010092-uftc8inx 11811 15 ) ) -RRB- cord-010092-uftc8inx 11811 16 improve improve VB cord-010092-uftc8inx 11811 17 the the DT cord-010092-uftc8inx 11811 18 quality quality NN cord-010092-uftc8inx 11811 19 and and CC cord-010092-uftc8inx 11811 20 drafting drafting NN cord-010092-uftc8inx 11811 21 of of IN cord-010092-uftc8inx 11811 22 work work NN cord-010092-uftc8inx 11811 23 procedures procedure NNS cord-010092-uftc8inx 11811 24 and and CC cord-010092-uftc8inx 11811 25 their -PRON- PRP$ cord-010092-uftc8inx 11811 26 compliance compliance NN cord-010092-uftc8inx 11811 27 , , , cord-010092-uftc8inx 11811 28 including include VBG cord-010092-uftc8inx 11811 29 procedures procedure NNS cord-010092-uftc8inx 11811 30 of of IN cord-010092-uftc8inx 11811 31 effective effective JJ cord-010092-uftc8inx 11811 32 communication communication NN cord-010092-uftc8inx 11811 33 between between IN cord-010092-uftc8inx 11811 34 professionals professional NNS cord-010092-uftc8inx 11811 35 , , , cord-010092-uftc8inx 11811 36 2 2 CD cord-010092-uftc8inx 11811 37 ) ) -RRB- cord-010092-uftc8inx 11811 38 train train NN cord-010092-uftc8inx 11811 39 staff staff NN cord-010092-uftc8inx 11811 40 in in IN cord-010092-uftc8inx 11811 41 knowledge knowledge NN cord-010092-uftc8inx 11811 42 important important JJ cord-010092-uftc8inx 11811 43 for for IN cord-010092-uftc8inx 11811 44 safety safety NN cord-010092-uftc8inx 11811 45 , , , cord-010092-uftc8inx 11811 46 3 3 CD cord-010092-uftc8inx 11811 47 ) ) -RRB- cord-010092-uftc8inx 11811 48 communicate communicate VBP cord-010092-uftc8inx 11811 49 with with IN cord-010092-uftc8inx 11811 50 computer computer NN cord-010092-uftc8inx 11811 51 application application NN cord-010092-uftc8inx 11811 52 providers provider NNS cord-010092-uftc8inx 11811 53 to to TO cord-010092-uftc8inx 11811 54 improve improve VB cord-010092-uftc8inx 11811 55 the the DT cord-010092-uftc8inx 11811 56 effectiveness effectiveness NN cord-010092-uftc8inx 11811 57 and and CC cord-010092-uftc8inx 11811 58 visibility visibility NN cord-010092-uftc8inx 11811 59 of of IN cord-010092-uftc8inx 11811 60 the the DT cord-010092-uftc8inx 11811 61 alerts alert NNS cord-010092-uftc8inx 11811 62 and and CC cord-010092-uftc8inx 11811 63 4 4 CD cord-010092-uftc8inx 11811 64 ) ) -RRB- cord-010092-uftc8inx 11812 1 involve involve VBP cord-010092-uftc8inx 11812 2 the the DT cord-010092-uftc8inx 11812 3 patient patient NN cord-010092-uftc8inx 11812 4 with with IN cord-010092-uftc8inx 11812 5 essential essential JJ cord-010092-uftc8inx 11812 6 information information NN cord-010092-uftc8inx 11812 7 to to TO cord-010092-uftc8inx 11812 8 ensure ensure VB cord-010092-uftc8inx 11812 9 transfusion transfusion NN cord-010092-uftc8inx 11812 10 safety safety NN cord-010092-uftc8inx 11812 11 . . . cord-010092-uftc8inx 11813 1 The the DT cord-010092-uftc8inx 11813 2 measures measure NNS cord-010092-uftc8inx 11813 3 were be VBD cord-010092-uftc8inx 11813 4 processed process VBN cord-010092-uftc8inx 11813 5 later later RB cord-010092-uftc8inx 11813 6 as as IN cord-010092-uftc8inx 11813 7 recommendations recommendation NNS cord-010092-uftc8inx 11813 8 . . . cord-010092-uftc8inx 11814 1 Summary Summary NNP cord-010092-uftc8inx 11814 2 / / SYM cord-010092-uftc8inx 11814 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 11814 4 : : : cord-010092-uftc8inx 11815 1 The the DT cord-010092-uftc8inx 11815 2 root root NN cord-010092-uftc8inx 11815 3 analysis analysis NN cord-010092-uftc8inx 11815 4 shows show VBZ cord-010092-uftc8inx 11815 5 agreement agreement NN cord-010092-uftc8inx 11815 6 between between IN cord-010092-uftc8inx 11815 7 participants participant NNS cord-010092-uftc8inx 11815 8 and and CC cord-010092-uftc8inx 11815 9 allows allow VBZ cord-010092-uftc8inx 11815 10 the the DT cord-010092-uftc8inx 11815 11 elaboration elaboration NN cord-010092-uftc8inx 11815 12 of of IN cord-010092-uftc8inx 11815 13 useful useful JJ cord-010092-uftc8inx 11815 14 recommendations recommendation NNS cord-010092-uftc8inx 11815 15 to to TO cord-010092-uftc8inx 11815 16 increase increase VB cord-010092-uftc8inx 11815 17 patient patient JJ cord-010092-uftc8inx 11815 18 safety safety NN cord-010092-uftc8inx 11815 19 . . . cord-010092-uftc8inx 11816 1 This this DT cord-010092-uftc8inx 11816 2 strategy strategy NN cord-010092-uftc8inx 11816 3 can can MD cord-010092-uftc8inx 11816 4 contribute contribute VB cord-010092-uftc8inx 11816 5 to to IN cord-010092-uftc8inx 11816 6 the the DT cord-010092-uftc8inx 11816 7 comprehensive comprehensive JJ cord-010092-uftc8inx 11816 8 prevention prevention NN cord-010092-uftc8inx 11816 9 of of IN cord-010092-uftc8inx 11816 10 errors error NNS cord-010092-uftc8inx 11816 11 . . . cord-010092-uftc8inx 11817 1 Background background NN cord-010092-uftc8inx 11817 2 : : : cord-010092-uftc8inx 11818 1 In in IN cord-010092-uftc8inx 11818 2 transfusion transfusion NN cord-010092-uftc8inx 11818 3 - - HYPH cord-010092-uftc8inx 11818 4 associated associate VBN cord-010092-uftc8inx 11818 5 circulatory circulatory JJ cord-010092-uftc8inx 11818 6 overload overload NN cord-010092-uftc8inx 11818 7 ( ( -LRB- cord-010092-uftc8inx 11818 8 TACO TACO NNP cord-010092-uftc8inx 11818 9 ) ) -RRB- cord-010092-uftc8inx 11818 10 , , , cord-010092-uftc8inx 11818 11 pulmonary pulmonary JJ cord-010092-uftc8inx 11818 12 oedema oedema NN cord-010092-uftc8inx 11818 13 develops develop VBZ cord-010092-uftc8inx 11818 14 primarily primarily RB cord-010092-uftc8inx 11818 15 due due JJ cord-010092-uftc8inx 11818 16 to to IN cord-010092-uftc8inx 11818 17 volume volume NN cord-010092-uftc8inx 11818 18 excess excess NN cord-010092-uftc8inx 11818 19 . . . cord-010092-uftc8inx 11819 1 Data datum NNS cord-010092-uftc8inx 11819 2 from from IN cord-010092-uftc8inx 11819 3 the the DT cord-010092-uftc8inx 11819 4 UK UK NNP cord-010092-uftc8inx 11819 5 haemovigilance haemovigilance NN cord-010092-uftc8inx 11819 6 scheme scheme NN cord-010092-uftc8inx 11819 7 , , , cord-010092-uftc8inx 11819 8 Serious Serious NNP cord-010092-uftc8inx 11819 9 Hazards Hazards NNPS cord-010092-uftc8inx 11819 10 of of IN cord-010092-uftc8inx 11819 11 Transfusion Transfusion NNP cord-010092-uftc8inx 11819 12 ( ( -LRB- cord-010092-uftc8inx 11819 13 SHOT shot NN cord-010092-uftc8inx 11819 14 ) ) -RRB- cord-010092-uftc8inx 11819 15 suggest suggest VBP cord-010092-uftc8inx 11819 16 that that IN cord-010092-uftc8inx 11819 17 either either CC cord-010092-uftc8inx 11819 18 the the DT cord-010092-uftc8inx 11819 19 incidence incidence NN cord-010092-uftc8inx 11819 20 of of IN cord-010092-uftc8inx 11819 21 TACO taco NN cord-010092-uftc8inx 11819 22 , , , cord-010092-uftc8inx 11819 23 or or CC cord-010092-uftc8inx 11819 24 the the DT cord-010092-uftc8inx 11819 25 recognition recognition NN cord-010092-uftc8inx 11819 26 and and CC cord-010092-uftc8inx 11819 27 reporting reporting NN cord-010092-uftc8inx 11819 28 of of IN cord-010092-uftc8inx 11819 29 TACO TACO NNP cord-010092-uftc8inx 11819 30 , , , cord-010092-uftc8inx 11819 31 has have VBZ cord-010092-uftc8inx 11819 32 increased increase VBN cord-010092-uftc8inx 11819 33 over over IN cord-010092-uftc8inx 11819 34 time time NN cord-010092-uftc8inx 11819 35 . . . cord-010092-uftc8inx 11820 1 From from IN cord-010092-uftc8inx 11820 2 2007 2007 CD cord-010092-uftc8inx 11820 3 to to IN cord-010092-uftc8inx 11820 4 2017 2017 CD cord-010092-uftc8inx 11820 5 , , , cord-010092-uftc8inx 11820 6 reports report NNS cord-010092-uftc8inx 11820 7 of of IN cord-010092-uftc8inx 11820 8 TACO TACO NNP cord-010092-uftc8inx 11820 9 increased increase VBD cord-010092-uftc8inx 11820 10 from from IN cord-010092-uftc8inx 11820 11 6 6 CD cord-010092-uftc8inx 11820 12 to to IN cord-010092-uftc8inx 11820 13 92 92 CD cord-010092-uftc8inx 11820 14 ; ; : cord-010092-uftc8inx 11820 15 deaths death NNS cord-010092-uftc8inx 11820 16 from from IN cord-010092-uftc8inx 11820 17 1 1 CD cord-010092-uftc8inx 11820 18 to to IN cord-010092-uftc8inx 11820 19 7 7 CD cord-010092-uftc8inx 11820 20 , , , cord-010092-uftc8inx 11820 21 major major JJ cord-010092-uftc8inx 11820 22 morbidity morbidity NN cord-010092-uftc8inx 11820 23 from from IN cord-010092-uftc8inx 11820 24 3 3 CD cord-010092-uftc8inx 11820 25 to to IN cord-010092-uftc8inx 11820 26 20 20 CD cord-010092-uftc8inx 11820 27 . . . cord-010092-uftc8inx 11821 1 Known know VBN cord-010092-uftc8inx 11821 2 risk risk NN cord-010092-uftc8inx 11821 3 factors factor NNS cord-010092-uftc8inx 11821 4 include include VBP cord-010092-uftc8inx 11821 5 pre pre JJ cord-010092-uftc8inx 11821 6 - - JJ cord-010092-uftc8inx 11821 7 existing existing JJ cord-010092-uftc8inx 11821 8 cardiac cardiac NN cord-010092-uftc8inx 11821 9 and/or and/or CC cord-010092-uftc8inx 11821 10 renal renal JJ cord-010092-uftc8inx 11821 11 dysfunction dysfunction NN cord-010092-uftc8inx 11821 12 , , , cord-010092-uftc8inx 11821 13 low low JJ cord-010092-uftc8inx 11821 14 body body NN cord-010092-uftc8inx 11821 15 weight weight NN cord-010092-uftc8inx 11821 16 , , , cord-010092-uftc8inx 11821 17 extremes extreme NNS cord-010092-uftc8inx 11821 18 of of IN cord-010092-uftc8inx 11821 19 age age NN cord-010092-uftc8inx 11821 20 ( ( -LRB- cord-010092-uftc8inx 11821 21 eg eg UH cord-010092-uftc8inx 11821 22 , , , cord-010092-uftc8inx 11821 23 <3 <3 NN cord-010092-uftc8inx 11821 24 years year NNS cord-010092-uftc8inx 11821 25 , , , cord-010092-uftc8inx 11821 26 > > XX cord-010092-uftc8inx 11821 27 60 60 CD cord-010092-uftc8inx 11821 28 years year NNS cord-010092-uftc8inx 11821 29 ) ) -RRB- cord-010092-uftc8inx 11821 30 , , , cord-010092-uftc8inx 11821 31 concomitant concomitant JJ cord-010092-uftc8inx 11821 32 fluid fluid JJ cord-010092-uftc8inx 11821 33 administration administration NN cord-010092-uftc8inx 11821 34 , , , cord-010092-uftc8inx 11821 35 positive positive JJ cord-010092-uftc8inx 11821 36 fluid fluid JJ cord-010092-uftc8inx 11821 37 balance balance NN cord-010092-uftc8inx 11821 38 , , , cord-010092-uftc8inx 11821 39 peripheral peripheral JJ cord-010092-uftc8inx 11821 40 oedema oedema NN cord-010092-uftc8inx 11821 41 and and CC cord-010092-uftc8inx 11821 42 hypoalbuminemia hypoalbuminemia NN cord-010092-uftc8inx 11821 43 . . . cord-010092-uftc8inx 11822 1 In in IN cord-010092-uftc8inx 11822 2 a a DT cord-010092-uftc8inx 11822 3 small small JJ cord-010092-uftc8inx 11822 4 subset subset NN cord-010092-uftc8inx 11822 5 of of IN cord-010092-uftc8inx 11822 6 cases case NNS cord-010092-uftc8inx 11822 7 reported report VBN cord-010092-uftc8inx 11822 8 to to IN cord-010092-uftc8inx 11822 9 SHOT SHOT NNP cord-010092-uftc8inx 11822 10 , , , cord-010092-uftc8inx 11822 11 TACO TACO NNP cord-010092-uftc8inx 11822 12 developed develop VBD cord-010092-uftc8inx 11822 13 following follow VBG cord-010092-uftc8inx 11822 14 transfusion transfusion NN cord-010092-uftc8inx 11822 15 for for IN cord-010092-uftc8inx 11822 16 severe severe JJ cord-010092-uftc8inx 11822 17 anaemia anaemia NN cord-010092-uftc8inx 11822 18 in in IN cord-010092-uftc8inx 11822 19 the the DT cord-010092-uftc8inx 11822 20 absence absence NN cord-010092-uftc8inx 11822 21 of of IN cord-010092-uftc8inx 11822 22 other other JJ cord-010092-uftc8inx 11822 23 risk risk NN cord-010092-uftc8inx 11822 24 factors factor NNS cord-010092-uftc8inx 11822 25 . . . cord-010092-uftc8inx 11823 1 This this DT cord-010092-uftc8inx 11823 2 may may MD cord-010092-uftc8inx 11823 3 be be VB cord-010092-uftc8inx 11823 4 an an DT cord-010092-uftc8inx 11823 5 under under RB cord-010092-uftc8inx 11823 6 - - HYPH cord-010092-uftc8inx 11823 7 recognised recognise VBN cord-010092-uftc8inx 11823 8 independent independent JJ cord-010092-uftc8inx 11823 9 risk risk NN cord-010092-uftc8inx 11823 10 - - HYPH cord-010092-uftc8inx 11823 11 factor factor NN cord-010092-uftc8inx 11823 12 . . . cord-010092-uftc8inx 11824 1 Aims aim VBZ cord-010092-uftc8inx 11824 2 : : : cord-010092-uftc8inx 11825 1 To to TO cord-010092-uftc8inx 11825 2 raise raise VB cord-010092-uftc8inx 11825 3 awareness awareness NN cord-010092-uftc8inx 11825 4 of of IN cord-010092-uftc8inx 11825 5 severe severe JJ cord-010092-uftc8inx 11825 6 anaemia anaemia NN cord-010092-uftc8inx 11825 7 as as IN cord-010092-uftc8inx 11825 8 an an DT cord-010092-uftc8inx 11825 9 under under RB cord-010092-uftc8inx 11825 10 - - HYPH cord-010092-uftc8inx 11825 11 recognised recognise VBN cord-010092-uftc8inx 11825 12 risk risk NN cord-010092-uftc8inx 11825 13 factor factor NN cord-010092-uftc8inx 11825 14 for for IN cord-010092-uftc8inx 11825 15 TACO taco NN cord-010092-uftc8inx 11825 16 and and CC cord-010092-uftc8inx 11825 17 is be VBZ cord-010092-uftc8inx 11825 18 potentially potentially RB cord-010092-uftc8inx 11825 19 life life NN cord-010092-uftc8inx 11825 20 - - HYPH cord-010092-uftc8inx 11825 21 threatening threaten VBG cord-010092-uftc8inx 11825 22 transfusion transfusion NN cord-010092-uftc8inx 11825 23 . . . cord-010092-uftc8inx 11826 1 Methods method NNS cord-010092-uftc8inx 11826 2 : : : cord-010092-uftc8inx 11826 3 Cases case NNS cord-010092-uftc8inx 11826 4 of of IN cord-010092-uftc8inx 11826 5 TACO taco NN cord-010092-uftc8inx 11826 6 submitted submit VBN cord-010092-uftc8inx 11826 7 to to IN cord-010092-uftc8inx 11826 8 SHOT shot VB cord-010092-uftc8inx 11826 9 over over IN cord-010092-uftc8inx 11826 10 the the DT cord-010092-uftc8inx 11826 11 last last JJ cord-010092-uftc8inx 11826 12 3 3 CD cord-010092-uftc8inx 11826 13 years year NNS cord-010092-uftc8inx 11826 14 were be VBD cord-010092-uftc8inx 11826 15 reviewed review VBN cord-010092-uftc8inx 11826 16 to to TO cord-010092-uftc8inx 11826 17 identify identify VB cord-010092-uftc8inx 11826 18 cases case NNS cord-010092-uftc8inx 11826 19 where where WRB cord-010092-uftc8inx 11826 20 transfusion transfusion NN cord-010092-uftc8inx 11826 21 for for IN cord-010092-uftc8inx 11826 22 severe severe JJ cord-010092-uftc8inx 11826 23 anaemia anaemia NN cord-010092-uftc8inx 11826 24 was be VBD cord-010092-uftc8inx 11826 25 a a DT cord-010092-uftc8inx 11826 26 key key JJ cord-010092-uftc8inx 11826 27 identifiable identifiable JJ cord-010092-uftc8inx 11826 28 patient patient JJ cord-010092-uftc8inx 11826 29 risk risk NN cord-010092-uftc8inx 11826 30 factor factor NN cord-010092-uftc8inx 11826 31 . . . cord-010092-uftc8inx 11827 1 Results result NNS cord-010092-uftc8inx 11827 2 : : : cord-010092-uftc8inx 11828 1 The the DT cord-010092-uftc8inx 11828 2 following follow VBG cord-010092-uftc8inx 11828 3 are be VBP cord-010092-uftc8inx 11828 4 illustrative illustrative JJ cord-010092-uftc8inx 11828 5 cases case NNS cord-010092-uftc8inx 11828 6 : : : cord-010092-uftc8inx 11829 1 -Case -case NN cord-010092-uftc8inx 11829 2 1 1 CD cord-010092-uftc8inx 11829 3 : : : cord-010092-uftc8inx 11829 4 A a DT cord-010092-uftc8inx 11829 5 patient patient NN cord-010092-uftc8inx 11829 6 in in IN cord-010092-uftc8inx 11829 7 their -PRON- PRP$ cord-010092-uftc8inx 11829 8 50s 50 NNS cord-010092-uftc8inx 11829 9 weighing weigh VBG cord-010092-uftc8inx 11829 10 67 67 CD cord-010092-uftc8inx 11829 11 kg kg NNS cord-010092-uftc8inx 11829 12 was be VBD cord-010092-uftc8inx 11829 13 prescribed prescribe VBN cord-010092-uftc8inx 11829 14 six six CD cord-010092-uftc8inx 11829 15 units unit NNS cord-010092-uftc8inx 11829 16 of of IN cord-010092-uftc8inx 11829 17 red red JJ cord-010092-uftc8inx 11829 18 cells cell NNS cord-010092-uftc8inx 11829 19 for for IN cord-010092-uftc8inx 11829 20 iron iron NN cord-010092-uftc8inx 11829 21 deficiency deficiency NN cord-010092-uftc8inx 11829 22 anaemia anaemia NN cord-010092-uftc8inx 11829 23 after after IN cord-010092-uftc8inx 11829 24 being be VBG cord-010092-uftc8inx 11829 25 admitted admit VBN cord-010092-uftc8inx 11829 26 with with IN cord-010092-uftc8inx 11829 27 Hb Hb NNP cord-010092-uftc8inx 11829 28 37 37 CD cord-010092-uftc8inx 11829 29 g g NN cord-010092-uftc8inx 11829 30 / / SYM cord-010092-uftc8inx 11829 31 L. L. NNP cord-010092-uftc8inx 11830 1 The the DT cord-010092-uftc8inx 11830 2 patient patient NN cord-010092-uftc8inx 11830 3 had have VBD cord-010092-uftc8inx 11830 4 no no DT cord-010092-uftc8inx 11830 5 risk risk NN cord-010092-uftc8inx 11830 6 factors factor NNS cord-010092-uftc8inx 11830 7 for for IN cord-010092-uftc8inx 11830 8 TACO taco NN cord-010092-uftc8inx 11830 9 except except IN cord-010092-uftc8inx 11830 10 for for IN cord-010092-uftc8inx 11830 11 profound profound JJ cord-010092-uftc8inx 11830 12 anaemia anaemia NN cord-010092-uftc8inx 11830 13 . . . cord-010092-uftc8inx 11831 1 During during IN cord-010092-uftc8inx 11831 2 transfusion transfusion NN cord-010092-uftc8inx 11831 3 of of IN cord-010092-uftc8inx 11831 4 the the DT cord-010092-uftc8inx 11831 5 fifth fifth JJ cord-010092-uftc8inx 11831 6 unit unit NN cord-010092-uftc8inx 11831 7 the the DT cord-010092-uftc8inx 11831 8 patient patient NN cord-010092-uftc8inx 11831 9 became become VBD cord-010092-uftc8inx 11831 10 dyspnoeic dyspnoeic NNS cord-010092-uftc8inx 11831 11 , , , cord-010092-uftc8inx 11831 12 hypoxic hypoxic JJ cord-010092-uftc8inx 11831 13 and and CC cord-010092-uftc8inx 11831 14 hypertensive hypertensive JJ cord-010092-uftc8inx 11831 15 . . . cord-010092-uftc8inx 11832 1 The the DT cord-010092-uftc8inx 11832 2 patient patient NN cord-010092-uftc8inx 11832 3 recovered recover VBD cord-010092-uftc8inx 11832 4 after after IN cord-010092-uftc8inx 11832 5 diuretic diuretic JJ cord-010092-uftc8inx 11832 6 therapy therapy NN cord-010092-uftc8inx 11832 7 and and CC cord-010092-uftc8inx 11832 8 had have VBD cord-010092-uftc8inx 11832 9 a a DT cord-010092-uftc8inx 11832 10 post post JJ cord-010092-uftc8inx 11832 11 - - JJ cord-010092-uftc8inx 11832 12 transfusion transfusion NN cord-010092-uftc8inx 11832 13 Hb Hb NNP cord-010092-uftc8inx 11832 14 level level NN cord-010092-uftc8inx 11832 15 of of IN cord-010092-uftc8inx 11832 16 100 100 CD cord-010092-uftc8inx 11832 17 g g NN cord-010092-uftc8inx 11832 18 / / SYM cord-010092-uftc8inx 11832 19 L. L. NNP cord-010092-uftc8inx 11832 20 -Case -Case NNP cord-010092-uftc8inx 11832 21 2 2 CD cord-010092-uftc8inx 11832 22 : : : cord-010092-uftc8inx 11833 1 A a DT cord-010092-uftc8inx 11833 2 patient patient NN cord-010092-uftc8inx 11833 3 in in IN cord-010092-uftc8inx 11833 4 their -PRON- PRP$ cord-010092-uftc8inx 11833 5 50s 50 NNS cord-010092-uftc8inx 11833 6 presented present VBN cord-010092-uftc8inx 11833 7 with with IN cord-010092-uftc8inx 11833 8 a a DT cord-010092-uftc8inx 11833 9 4-week 4-week CD cord-010092-uftc8inx 11833 10 history history NN cord-010092-uftc8inx 11833 11 of of IN cord-010092-uftc8inx 11833 12 weakness weakness NN cord-010092-uftc8inx 11833 13 and and CC cord-010092-uftc8inx 11833 14 dizziness dizziness NN cord-010092-uftc8inx 11833 15 and and CC cord-010092-uftc8inx 11833 16 had have VBD cord-010092-uftc8inx 11833 17 felt feel VBN cord-010092-uftc8inx 11833 18 unwell unwell JJ cord-010092-uftc8inx 11833 19 for for IN cord-010092-uftc8inx 11833 20 6 6 CD cord-010092-uftc8inx 11833 21 months month NNS cord-010092-uftc8inx 11833 22 . . . cord-010092-uftc8inx 11834 1 The the DT cord-010092-uftc8inx 11834 2 Hb Hb NNP cord-010092-uftc8inx 11834 3 was be VBD cord-010092-uftc8inx 11834 4 34 34 CD cord-010092-uftc8inx 11834 5 g g NN cord-010092-uftc8inx 11834 6 / / SYM cord-010092-uftc8inx 11834 7 L L NNP cord-010092-uftc8inx 11834 8 , , , cord-010092-uftc8inx 11834 9 ferritin ferritin NN cord-010092-uftc8inx 11834 10 26 26 CD cord-010092-uftc8inx 11834 11 lg lg NNP cord-010092-uftc8inx 11834 12 / / SYM cord-010092-uftc8inx 11834 13 L L NNP cord-010092-uftc8inx 11834 14 and and CC cord-010092-uftc8inx 11834 15 ECG ECG NNP cord-010092-uftc8inx 11834 16 showed show VBD cord-010092-uftc8inx 11834 17 cardiac cardiac JJ cord-010092-uftc8inx 11834 18 ischaemia ischaemia NN cord-010092-uftc8inx 11834 19 . . . cord-010092-uftc8inx 11835 1 Two two CD cord-010092-uftc8inx 11835 2 units unit NNS cord-010092-uftc8inx 11835 3 of of IN cord-010092-uftc8inx 11835 4 red red JJ cord-010092-uftc8inx 11835 5 cells cell NNS cord-010092-uftc8inx 11835 6 were be VBD cord-010092-uftc8inx 11835 7 transfused transfuse VBN cord-010092-uftc8inx 11835 8 . . . cord-010092-uftc8inx 11836 1 After after IN cord-010092-uftc8inx 11836 2 the the DT cord-010092-uftc8inx 11836 3 second second JJ cord-010092-uftc8inx 11836 4 unit unit NN cord-010092-uftc8inx 11836 5 oxygen oxygen NN cord-010092-uftc8inx 11836 6 saturations saturation NNS cord-010092-uftc8inx 11836 7 fell fall VBD cord-010092-uftc8inx 11836 8 despite despite IN cord-010092-uftc8inx 11836 9 supplemental supplemental JJ cord-010092-uftc8inx 11836 10 oxygen oxygen NN cord-010092-uftc8inx 11836 11 , , , cord-010092-uftc8inx 11836 12 post post JJ cord-010092-uftc8inx 11836 13 - - JJ cord-010092-uftc8inx 11836 14 transfusion transfusion NN cord-010092-uftc8inx 11836 15 Hb Hb NNP cord-010092-uftc8inx 11836 16 of of IN cord-010092-uftc8inx 11837 1 51 51 CD cord-010092-uftc8inx 11837 2 g g NN cord-010092-uftc8inx 11837 3 / / SYM cord-010092-uftc8inx 11837 4 L. L. NNP cord-010092-uftc8inx 11837 5 A a DT cord-010092-uftc8inx 11837 6 third third JJ cord-010092-uftc8inx 11837 7 unit unit NN cord-010092-uftc8inx 11837 8 was be VBD cord-010092-uftc8inx 11837 9 transfused transfuse VBN cord-010092-uftc8inx 11837 10 over over IN cord-010092-uftc8inx 11837 11 125 125 CD cord-010092-uftc8inx 11837 12 min min NN cord-010092-uftc8inx 11837 13 and and CC cord-010092-uftc8inx 11837 14 the the DT cord-010092-uftc8inx 11837 15 hypoxia hypoxia NN cord-010092-uftc8inx 11837 16 worsened worsen VBD cord-010092-uftc8inx 11837 17 with with IN cord-010092-uftc8inx 11837 18 dyspnoea dyspnoea NNS cord-010092-uftc8inx 11837 19 and and CC cord-010092-uftc8inx 11837 20 crackles crackle NNS cord-010092-uftc8inx 11837 21 on on IN cord-010092-uftc8inx 11837 22 chest chest NN cord-010092-uftc8inx 11837 23 auscultation auscultation NN cord-010092-uftc8inx 11837 24 . . . cord-010092-uftc8inx 11838 1 The the DT cord-010092-uftc8inx 11838 2 chest chest NN cord-010092-uftc8inx 11838 3 x x NN cord-010092-uftc8inx 11838 4 - - NN cord-010092-uftc8inx 11838 5 ray ray NN cord-010092-uftc8inx 11838 6 showed show VBD cord-010092-uftc8inx 11838 7 an an DT cord-010092-uftc8inx 11838 8 enlarged enlarged JJ cord-010092-uftc8inx 11838 9 cardiac cardiac JJ cord-010092-uftc8inx 11838 10 silhouette silhouette NN cord-010092-uftc8inx 11838 11 and and CC cord-010092-uftc8inx 11838 12 pulmonary pulmonary JJ cord-010092-uftc8inx 11838 13 congestion congestion NN cord-010092-uftc8inx 11838 14 . . . cord-010092-uftc8inx 11839 1 The the DT cord-010092-uftc8inx 11839 2 patient patient NN cord-010092-uftc8inx 11839 3 improved improve VBD cord-010092-uftc8inx 11839 4 with with IN cord-010092-uftc8inx 11839 5 diuretics diuretic NNS cord-010092-uftc8inx 11839 6 . . . cord-010092-uftc8inx 11840 1 -Case -case NN cord-010092-uftc8inx 11840 2 3 3 CD cord-010092-uftc8inx 11841 1 : : : cord-010092-uftc8inx 11841 2 A a DT cord-010092-uftc8inx 11841 3 patient patient NN cord-010092-uftc8inx 11841 4 in in IN cord-010092-uftc8inx 11841 5 their -PRON- PRP$ cord-010092-uftc8inx 11841 6 90s 90 NNS cord-010092-uftc8inx 11841 7 with with IN cord-010092-uftc8inx 11841 8 severe severe JJ cord-010092-uftc8inx 11841 9 megaloblastic megaloblastic JJ cord-010092-uftc8inx 11841 10 anaemia anaemia NN cord-010092-uftc8inx 11841 11 , , , cord-010092-uftc8inx 11841 12 Hb Hb NNP cord-010092-uftc8inx 11841 13 41 41 CD cord-010092-uftc8inx 11841 14 g g NNP cord-010092-uftc8inx 11841 15 / / SYM cord-010092-uftc8inx 11841 16 L l NN cord-010092-uftc8inx 11841 17 and and CC cord-010092-uftc8inx 11841 18 peripheral peripheral JJ cord-010092-uftc8inx 11841 19 oedema oedema NN cord-010092-uftc8inx 11841 20 developed develop VBD cord-010092-uftc8inx 11841 21 TACO taco NN cord-010092-uftc8inx 11841 22 after after IN cord-010092-uftc8inx 11841 23 transfusion transfusion NN cord-010092-uftc8inx 11841 24 of of IN cord-010092-uftc8inx 11841 25 3 3 CD cord-010092-uftc8inx 11841 26 units unit NNS cord-010092-uftc8inx 11841 27 and and CC cord-010092-uftc8inx 11841 28 recovered recover VBD cord-010092-uftc8inx 11841 29 with with IN cord-010092-uftc8inx 11841 30 diuretic diuretic JJ cord-010092-uftc8inx 11841 31 therapy therapy NN cord-010092-uftc8inx 11841 32 . . . cord-010092-uftc8inx 11842 1 Summary Summary NNP cord-010092-uftc8inx 11842 2 / / SYM cord-010092-uftc8inx 11842 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 11842 4 : : : cord-010092-uftc8inx 11843 1 Chronic chronic JJ cord-010092-uftc8inx 11843 2 and and CC cord-010092-uftc8inx 11843 3 acute acute JJ cord-010092-uftc8inx 11843 4 anaemia anaemia NN cord-010092-uftc8inx 11843 5 are be VBP cord-010092-uftc8inx 11843 6 associated associate VBN cord-010092-uftc8inx 11843 7 with with IN cord-010092-uftc8inx 11843 8 compensatory compensatory JJ cord-010092-uftc8inx 11843 9 cardiac cardiac JJ cord-010092-uftc8inx 11843 10 changes change NNS cord-010092-uftc8inx 11843 11 irrespective irrespective RB cord-010092-uftc8inx 11843 12 of of IN cord-010092-uftc8inx 11843 13 the the DT cord-010092-uftc8inx 11843 14 aetiology aetiology NN cord-010092-uftc8inx 11843 15 of of IN cord-010092-uftc8inx 11843 16 anaemia anaemia NN cord-010092-uftc8inx 11843 17 . . . cord-010092-uftc8inx 11844 1 This this DT cord-010092-uftc8inx 11844 2 is be VBZ cord-010092-uftc8inx 11844 3 further further RB cord-010092-uftc8inx 11844 4 compounded compound VBN cord-010092-uftc8inx 11844 5 by by IN cord-010092-uftc8inx 11844 6 the the DT cord-010092-uftc8inx 11844 7 underlying underlying JJ cord-010092-uftc8inx 11844 8 cause cause NN cord-010092-uftc8inx 11844 9 of of IN cord-010092-uftc8inx 11844 10 anaemia anaemia NN cord-010092-uftc8inx 11844 11 particularly particularly RB cord-010092-uftc8inx 11844 12 haematinic haematinic JJ cord-010092-uftc8inx 11844 13 deficiencies deficiency NNS cord-010092-uftc8inx 11844 14 ( ( -LRB- cord-010092-uftc8inx 11844 15 iron iron NN cord-010092-uftc8inx 11844 16 / / SYM cord-010092-uftc8inx 11844 17 B12 B12 NNP cord-010092-uftc8inx 11844 18 deficiency deficiency NN cord-010092-uftc8inx 11844 19 ) ) -RRB- cord-010092-uftc8inx 11844 20 that that WDT cord-010092-uftc8inx 11844 21 independently independently RB cord-010092-uftc8inx 11844 22 affect affect VBP cord-010092-uftc8inx 11844 23 myocardial myocardial JJ cord-010092-uftc8inx 11844 24 function function NN cord-010092-uftc8inx 11844 25 . . . cord-010092-uftc8inx 11845 1 Hyperdynamic Hyperdynamic NNP cord-010092-uftc8inx 11845 2 circulation circulation NN cord-010092-uftc8inx 11845 3 related relate VBN cord-010092-uftc8inx 11845 4 to to IN cord-010092-uftc8inx 11845 5 anaemia anaemia NN cord-010092-uftc8inx 11845 6 increases increase VBZ cord-010092-uftc8inx 11845 7 the the DT cord-010092-uftc8inx 11845 8 load load NN cord-010092-uftc8inx 11845 9 on on IN cord-010092-uftc8inx 11845 10 the the DT cord-010092-uftc8inx 11845 11 heart heart NN cord-010092-uftc8inx 11845 12 , , , cord-010092-uftc8inx 11845 13 causing cause VBG cord-010092-uftc8inx 11845 14 myocardial myocardial JJ cord-010092-uftc8inx 11845 15 ischaemia ischaemia NN cord-010092-uftc8inx 11845 16 and and CC cord-010092-uftc8inx 11845 17 hypoxia hypoxia NN cord-010092-uftc8inx 11845 18 and and CC cord-010092-uftc8inx 11845 19 if if IN cord-010092-uftc8inx 11845 20 the the DT cord-010092-uftc8inx 11845 21 anaemia anaemia NN cord-010092-uftc8inx 11845 22 is be VBZ cord-010092-uftc8inx 11845 23 not not RB cord-010092-uftc8inx 11845 24 corrected correct VBN cord-010092-uftc8inx 11845 25 , , , cord-010092-uftc8inx 11845 26 eventually eventually RB cord-010092-uftc8inx 11845 27 leads lead VBZ cord-010092-uftc8inx 11845 28 to to IN cord-010092-uftc8inx 11845 29 heart heart NN cord-010092-uftc8inx 11845 30 failure failure NN cord-010092-uftc8inx 11845 31 . . . cord-010092-uftc8inx 11846 1 Clinicians clinician NNS cord-010092-uftc8inx 11846 2 need need VBP cord-010092-uftc8inx 11846 3 to to TO cord-010092-uftc8inx 11846 4 make make VB cord-010092-uftc8inx 11846 5 an an DT cord-010092-uftc8inx 11846 6 accurate accurate JJ cord-010092-uftc8inx 11846 7 diagnosis diagnosis NN cord-010092-uftc8inx 11846 8 and and CC cord-010092-uftc8inx 11846 9 avoid avoid VB cord-010092-uftc8inx 11846 10 excessive excessive JJ cord-010092-uftc8inx 11846 11 transfusion transfusion NN cord-010092-uftc8inx 11846 12 in in IN cord-010092-uftc8inx 11846 13 patients patient NNS cord-010092-uftc8inx 11846 14 with with IN cord-010092-uftc8inx 11846 15 severe severe JJ cord-010092-uftc8inx 11846 16 anaemia anaemia NN cord-010092-uftc8inx 11846 17 with with IN cord-010092-uftc8inx 11846 18 or or CC cord-010092-uftc8inx 11846 19 without without IN cord-010092-uftc8inx 11846 20 other other JJ cord-010092-uftc8inx 11846 21 additional additional JJ cord-010092-uftc8inx 11846 22 risk risk NN cord-010092-uftc8inx 11846 23 factors factor NNS cord-010092-uftc8inx 11846 24 . . . cord-010092-uftc8inx 11847 1 Patients patient NNS cord-010092-uftc8inx 11847 2 with with IN cord-010092-uftc8inx 11847 3 chronic chronic JJ cord-010092-uftc8inx 11847 4 iron iron NN cord-010092-uftc8inx 11847 5 / / SYM cord-010092-uftc8inx 11847 6 folate folate NN cord-010092-uftc8inx 11847 7 / / SYM cord-010092-uftc8inx 11847 8 B12 B12 NNP cord-010092-uftc8inx 11847 9 deficiency deficiency NN cord-010092-uftc8inx 11847 10 without without IN cord-010092-uftc8inx 11847 11 haemodynamic haemodynamic JJ cord-010092-uftc8inx 11847 12 instability instability NN cord-010092-uftc8inx 11847 13 should should MD cord-010092-uftc8inx 11847 14 be be VB cord-010092-uftc8inx 11847 15 given give VBN cord-010092-uftc8inx 11847 16 the the DT cord-010092-uftc8inx 11847 17 appropriate appropriate JJ cord-010092-uftc8inx 11847 18 haematinic haematinic NNP cord-010092-uftc8inx 11847 19 replacement replacement NN cord-010092-uftc8inx 11847 20 . . . cord-010092-uftc8inx 11848 1 Haematinic Haematinic NNP cord-010092-uftc8inx 11848 2 deficiency deficiency NN cord-010092-uftc8inx 11848 3 responds respond VBZ cord-010092-uftc8inx 11848 4 rapidly rapidly RB cord-010092-uftc8inx 11848 5 to to TO cord-010092-uftc8inx 11848 6 appropriate appropriate JJ cord-010092-uftc8inx 11848 7 vitamin vitamin NN cord-010092-uftc8inx 11848 8 / / SYM cord-010092-uftc8inx 11848 9 mineral mineral NN cord-010092-uftc8inx 11848 10 . . . cord-010092-uftc8inx 11849 1 Blood blood NN cord-010092-uftc8inx 11849 2 transfusions transfusion NNS cord-010092-uftc8inx 11849 3 are be VBP cord-010092-uftc8inx 11849 4 to to TO cord-010092-uftc8inx 11849 5 be be VB cord-010092-uftc8inx 11849 6 given give VBN cord-010092-uftc8inx 11849 7 only only RB cord-010092-uftc8inx 11849 8 when when WRB cord-010092-uftc8inx 11849 9 clinically clinically RB cord-010092-uftc8inx 11849 10 indicated indicate VBN cord-010092-uftc8inx 11849 11 and and CC cord-010092-uftc8inx 11849 12 even even RB cord-010092-uftc8inx 11849 13 then then RB cord-010092-uftc8inx 11849 14 , , , cord-010092-uftc8inx 11849 15 only only RB cord-010092-uftc8inx 11849 16 the the DT cord-010092-uftc8inx 11849 17 minimum minimum JJ cord-010092-uftc8inx 11849 18 volume volume NN cord-010092-uftc8inx 11849 19 needed need VBN cord-010092-uftc8inx 11849 20 for for IN cord-010092-uftc8inx 11849 21 symptomatic symptomatic JJ cord-010092-uftc8inx 11849 22 relief relief NN cord-010092-uftc8inx 11849 23 transfused transfuse VBN cord-010092-uftc8inx 11849 24 with with IN cord-010092-uftc8inx 11849 25 consideration consideration NN cord-010092-uftc8inx 11849 26 for for IN cord-010092-uftc8inx 11849 27 diuretic diuretic JJ cord-010092-uftc8inx 11849 28 therapy therapy NN cord-010092-uftc8inx 11849 29 . . . cord-010092-uftc8inx 11850 1 Methods method NNS cord-010092-uftc8inx 11850 2 : : : cord-010092-uftc8inx 11850 3 Legal legal JJ cord-010092-uftc8inx 11850 4 forms form NNS cord-010092-uftc8inx 11850 5 for for IN cord-010092-uftc8inx 11850 6 reporting report VBG cord-010092-uftc8inx 11850 7 transfusion transfusion NN cord-010092-uftc8inx 11850 8 reactions reaction NNS cord-010092-uftc8inx 11850 9 were be VBD cord-010092-uftc8inx 11850 10 used use VBN cord-010092-uftc8inx 11850 11 in in IN cord-010092-uftc8inx 11850 12 the the DT cord-010092-uftc8inx 11850 13 retrospective retrospective JJ cord-010092-uftc8inx 11850 14 analysis analysis NN cord-010092-uftc8inx 11850 15 , , , cord-010092-uftc8inx 11850 16 which which WDT cord-010092-uftc8inx 11850 17 were be VBD cord-010092-uftc8inx 11850 18 adjusted adjust VBN cord-010092-uftc8inx 11850 19 by by IN cord-010092-uftc8inx 11850 20 the the DT cord-010092-uftc8inx 11850 21 Department Department NNP cord-010092-uftc8inx 11850 22 of of IN cord-010092-uftc8inx 11850 23 Quality Quality NNP cord-010092-uftc8inx 11850 24 Assurance Assurance NNP cord-010092-uftc8inx 11850 25 and and CC cord-010092-uftc8inx 11850 26 Quality Quality NNP cord-010092-uftc8inx 11850 27 Control Control NNP cord-010092-uftc8inx 11850 28 in in IN cord-010092-uftc8inx 11850 29 the the DT cord-010092-uftc8inx 11850 30 electronic electronic JJ cord-010092-uftc8inx 11850 31 form form NN cord-010092-uftc8inx 11850 32 and and CC cord-010092-uftc8inx 11850 33 distributed distribute VBN cord-010092-uftc8inx 11850 34 to to IN cord-010092-uftc8inx 11850 35 clinics clinic NNS cord-010092-uftc8inx 11850 36 using use VBG cord-010092-uftc8inx 11850 37 blood blood NN cord-010092-uftc8inx 11850 38 components component NNS cord-010092-uftc8inx 11850 39 . . . cord-010092-uftc8inx 11851 1 Clinicians clinician NNS cord-010092-uftc8inx 11851 2 were be VBD cord-010092-uftc8inx 11851 3 trained train VBN cord-010092-uftc8inx 11851 4 to to TO cord-010092-uftc8inx 11851 5 report report VB cord-010092-uftc8inx 11851 6 transfusion transfusion NN cord-010092-uftc8inx 11851 7 reactions reaction NNS cord-010092-uftc8inx 11851 8 through through IN cord-010092-uftc8inx 11851 9 the the DT cord-010092-uftc8inx 11851 10 Hospital Hospital NNP cord-010092-uftc8inx 11851 11 's 's POS cord-010092-uftc8inx 11851 12 Transfusion Transfusion NNP cord-010092-uftc8inx 11851 13 Board Board NNP cord-010092-uftc8inx 11851 14 and and CC cord-010092-uftc8inx 11851 15 through through IN cord-010092-uftc8inx 11851 16 the the DT cord-010092-uftc8inx 11851 17 " " `` cord-010092-uftc8inx 11851 18 Service Service NNP cord-010092-uftc8inx 11851 19 for for IN cord-010092-uftc8inx 11851 20 Improvement Improvement NNP cord-010092-uftc8inx 11851 21 of of IN cord-010092-uftc8inx 11851 22 the the DT cord-010092-uftc8inx 11851 23 Quality Quality NNP cord-010092-uftc8inx 11851 24 and and CC cord-010092-uftc8inx 11851 25 Safety Safety NNP cord-010092-uftc8inx 11851 26 of of IN cord-010092-uftc8inx 11851 27 Health Health NNP cord-010092-uftc8inx 11851 28 Services Services NNPS cord-010092-uftc8inx 11851 29 " " '' cord-010092-uftc8inx 11851 30 at at IN cord-010092-uftc8inx 11851 31 the the DT cord-010092-uftc8inx 11851 32 Clinical Clinical NNP cord-010092-uftc8inx 11851 33 Center Center NNP cord-010092-uftc8inx 11851 34 of of IN cord-010092-uftc8inx 11851 35 Sarajevo Sarajevo NNP cord-010092-uftc8inx 11851 36 . . . cord-010092-uftc8inx 11852 1 Analysis analysis NN cord-010092-uftc8inx 11852 2 of of IN cord-010092-uftc8inx 11852 3 the the DT cord-010092-uftc8inx 11852 4 reported report VBN cord-010092-uftc8inx 11852 5 reactions reaction NNS cord-010092-uftc8inx 11852 6 in in IN cord-010092-uftc8inx 11852 7 the the DT cord-010092-uftc8inx 11852 8 Institute Institute NNP cord-010092-uftc8inx 11852 9 include include VBP cord-010092-uftc8inx 11852 10 immunohematological immunohematological JJ cord-010092-uftc8inx 11852 11 and and CC cord-010092-uftc8inx 11852 12 microbiological microbiological JJ cord-010092-uftc8inx 11852 13 examination examination NN cord-010092-uftc8inx 11852 14 based base VBN cord-010092-uftc8inx 11852 15 on on IN cord-010092-uftc8inx 11852 16 which which WDT cord-010092-uftc8inx 11852 17 the the DT cord-010092-uftc8inx 11852 18 guidelines guideline NNS cord-010092-uftc8inx 11852 19 for for IN cord-010092-uftc8inx 11852 20 further further JJ cord-010092-uftc8inx 11852 21 treatment treatment NN cord-010092-uftc8inx 11852 22 with with IN cord-010092-uftc8inx 11852 23 blood blood NN cord-010092-uftc8inx 11852 24 components component NNS cord-010092-uftc8inx 11852 25 are be VBP cord-010092-uftc8inx 11852 26 being be VBG cord-010092-uftc8inx 11852 27 made make VBN cord-010092-uftc8inx 11852 28 . . . cord-010092-uftc8inx 11853 1 Users user NNS cord-010092-uftc8inx 11853 2 of of IN cord-010092-uftc8inx 11853 3 registered register VBN cord-010092-uftc8inx 11853 4 services service NNS cord-010092-uftc8inx 11853 5 are be VBP cord-010092-uftc8inx 11853 6 obliged oblige VBN cord-010092-uftc8inx 11853 7 to to TO cord-010092-uftc8inx 11853 8 report report VB cord-010092-uftc8inx 11853 9 since since IN cord-010092-uftc8inx 11853 10 2015 2015 CD cord-010092-uftc8inx 11853 11 . . . cord-010092-uftc8inx 11854 1 Results result NNS cord-010092-uftc8inx 11854 2 : : : cord-010092-uftc8inx 11855 1 Total total NN cord-010092-uftc8inx 11855 2 of of IN cord-010092-uftc8inx 11855 3 121,076 121,076 CD cord-010092-uftc8inx 11855 4 different different JJ cord-010092-uftc8inx 11855 5 blood blood NN cord-010092-uftc8inx 11855 6 components component NNS cord-010092-uftc8inx 11855 7 were be VBD cord-010092-uftc8inx 11855 8 applied apply VBN cord-010092-uftc8inx 11855 9 in in IN cord-010092-uftc8inx 11855 10 the the DT cord-010092-uftc8inx 11855 11 period period NN cord-010092-uftc8inx 11855 12 between between IN cord-010092-uftc8inx 11855 13 2015 2015 CD cord-010092-uftc8inx 11855 14 - - SYM cord-010092-uftc8inx 11855 15 2018 2018 CD cord-010092-uftc8inx 11855 16 . . . cord-010092-uftc8inx 11856 1 Department Department NNP cord-010092-uftc8inx 11856 2 for for IN cord-010092-uftc8inx 11856 3 Quality Quality NNP cord-010092-uftc8inx 11856 4 Assurance Assurance NNP cord-010092-uftc8inx 11856 5 and and CC cord-010092-uftc8inx 11856 6 Control Control NNP cord-010092-uftc8inx 11856 7 has have VBZ cord-010092-uftc8inx 11856 8 received receive VBN cord-010092-uftc8inx 11856 9 4 4 CD cord-010092-uftc8inx 11856 10 serious serious JJ cord-010092-uftc8inx 11856 11 adverse adverse JJ cord-010092-uftc8inx 11856 12 reactions reaction NNS cord-010092-uftc8inx 11856 13 , , , cord-010092-uftc8inx 11856 14 1 1 CD cord-010092-uftc8inx 11856 15 serious serious JJ cord-010092-uftc8inx 11856 16 adverse adverse JJ cord-010092-uftc8inx 11856 17 event event NN cord-010092-uftc8inx 11856 18 , , , cord-010092-uftc8inx 11856 19 157 157 CD cord-010092-uftc8inx 11856 20 reports report NNS cord-010092-uftc8inx 11856 21 of of IN cord-010092-uftc8inx 11856 22 transfusion transfusion NN cord-010092-uftc8inx 11856 23 reactions reaction NNS cord-010092-uftc8inx 11856 24 , , , cord-010092-uftc8inx 11856 25 of of IN cord-010092-uftc8inx 11856 26 which which WDT cord-010092-uftc8inx 11856 27 11 11 CD cord-010092-uftc8inx 11856 28 ( ( -LRB- cord-010092-uftc8inx 11856 29 7 7 CD cord-010092-uftc8inx 11856 30 % % NN cord-010092-uftc8inx 11856 31 ) ) -RRB- cord-010092-uftc8inx 11856 32 were be VBD cord-010092-uftc8inx 11856 33 inadequately inadequately RB cord-010092-uftc8inx 11856 34 filled fill VBN cord-010092-uftc8inx 11856 35 , , , cord-010092-uftc8inx 11856 36 in in IN cord-010092-uftc8inx 11856 37 the the DT cord-010092-uftc8inx 11856 38 same same JJ cord-010092-uftc8inx 11856 39 period period NN cord-010092-uftc8inx 11856 40 . . . cord-010092-uftc8inx 11857 1 From from IN cord-010092-uftc8inx 11857 2 the the DT cord-010092-uftc8inx 11857 3 above above JJ cord-010092-uftc8inx 11857 4 , , , cord-010092-uftc8inx 11857 5 54 54 CD cord-010092-uftc8inx 11857 6 ( ( -LRB- cord-010092-uftc8inx 11857 7 34.39 34.39 CD cord-010092-uftc8inx 11857 8 % % NN cord-010092-uftc8inx 11857 9 ) ) -RRB- cord-010092-uftc8inx 11857 10 were be VBD cord-010092-uftc8inx 11857 11 transfusion transfusion NN cord-010092-uftc8inx 11857 12 reactions reaction NNS cord-010092-uftc8inx 11857 13 to to IN cord-010092-uftc8inx 11857 14 erythrocyte erythrocyte NN cord-010092-uftc8inx 11857 15 blood blood NN cord-010092-uftc8inx 11857 16 components component NNS cord-010092-uftc8inx 11857 17 which which WDT cord-010092-uftc8inx 11857 18 were be VBD cord-010092-uftc8inx 11857 19 applied apply VBN cord-010092-uftc8inx 11857 20 , , , cord-010092-uftc8inx 11857 21 86 86 CD cord-010092-uftc8inx 11857 22 ( ( -LRB- cord-010092-uftc8inx 11857 23 54.77 54.77 CD cord-010092-uftc8inx 11857 24 % % NN cord-010092-uftc8inx 11857 25 ) ) -RRB- cord-010092-uftc8inx 11857 26 to to TO cord-010092-uftc8inx 11857 27 platelet platelet NN cord-010092-uftc8inx 11857 28 components component NNS cord-010092-uftc8inx 11857 29 and and CC cord-010092-uftc8inx 11857 30 17 17 CD cord-010092-uftc8inx 11857 31 ( ( -LRB- cord-010092-uftc8inx 11857 32 10.82 10.82 CD cord-010092-uftc8inx 11857 33 % % NN cord-010092-uftc8inx 11857 34 ) ) -RRB- cord-010092-uftc8inx 11857 35 were be VBD cord-010092-uftc8inx 11857 36 transfusion transfusion NN cord-010092-uftc8inx 11857 37 reactions reaction NNS cord-010092-uftc8inx 11857 38 after after IN cord-010092-uftc8inx 11857 39 the the DT cord-010092-uftc8inx 11857 40 application application NN cord-010092-uftc8inx 11857 41 of of IN cord-010092-uftc8inx 11857 42 fresh fresh JJ cord-010092-uftc8inx 11857 43 frozen frozen JJ cord-010092-uftc8inx 11857 44 plasma plasma NN cord-010092-uftc8inx 11857 45 . . . cord-010092-uftc8inx 11858 1 The the DT cord-010092-uftc8inx 11858 2 analysis analysis NN cord-010092-uftc8inx 11858 3 has have VBZ cord-010092-uftc8inx 11858 4 shown show VBN cord-010092-uftc8inx 11858 5 that that IN cord-010092-uftc8inx 11858 6 the the DT cord-010092-uftc8inx 11858 7 most most RBS cord-010092-uftc8inx 11858 8 frequent frequent JJ cord-010092-uftc8inx 11858 9 were be VBD cord-010092-uftc8inx 11858 10 febrile febrile JJ cord-010092-uftc8inx 11858 11 non non JJ cord-010092-uftc8inx 11858 12 - - JJ cord-010092-uftc8inx 11858 13 haemolysis haemolysis JJ cord-010092-uftc8inx 11858 14 reactions reaction NNS cord-010092-uftc8inx 11858 15 ( ( -LRB- cord-010092-uftc8inx 11858 16 88 88 CD cord-010092-uftc8inx 11858 17 or or CC cord-010092-uftc8inx 11858 18 56.05 56.05 CD cord-010092-uftc8inx 11858 19 % % NN cord-010092-uftc8inx 11858 20 ) ) -RRB- cord-010092-uftc8inx 11858 21 , , , cord-010092-uftc8inx 11858 22 followed follow VBN cord-010092-uftc8inx 11858 23 by by IN cord-010092-uftc8inx 11858 24 allergic allergic JJ cord-010092-uftc8inx 11858 25 reactions reaction NNS cord-010092-uftc8inx 11858 26 ( ( -LRB- cord-010092-uftc8inx 11858 27 50 50 CD cord-010092-uftc8inx 11858 28 or or CC cord-010092-uftc8inx 11858 29 31.84 31.84 CD cord-010092-uftc8inx 11858 30 % % NN cord-010092-uftc8inx 11858 31 ) ) -RRB- cord-010092-uftc8inx 11858 32 . . . cord-010092-uftc8inx 11859 1 Two two CD cord-010092-uftc8inx 11859 2 transfusion transfusion NN cord-010092-uftc8inx 11859 3 reactions reaction NNS cord-010092-uftc8inx 11859 4 ( ( -LRB- cord-010092-uftc8inx 11859 5 1.27 1.27 CD cord-010092-uftc8inx 11859 6 % % NN cord-010092-uftc8inx 11859 7 ) ) -RRB- cord-010092-uftc8inx 11859 8 were be VBD cord-010092-uftc8inx 11859 9 characterized characterize VBN cord-010092-uftc8inx 11859 10 as as IN cord-010092-uftc8inx 11859 11 circulation circulation NN cord-010092-uftc8inx 11859 12 overload overload NN cord-010092-uftc8inx 11859 13 . . . cord-010092-uftc8inx 11860 1 Summary Summary NNP cord-010092-uftc8inx 11860 2 / / SYM cord-010092-uftc8inx 11860 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 11860 4 : : : cord-010092-uftc8inx 11861 1 The the DT cord-010092-uftc8inx 11861 2 frequency frequency NN cord-010092-uftc8inx 11861 3 of of IN cord-010092-uftc8inx 11861 4 serious serious JJ cord-010092-uftc8inx 11861 5 adverse adverse JJ cord-010092-uftc8inx 11861 6 reactions reaction NNS cord-010092-uftc8inx 11861 7 and and CC cord-010092-uftc8inx 11861 8 events event NNS cord-010092-uftc8inx 11861 9 was be VBD cord-010092-uftc8inx 11861 10 0.004 0.004 CD cord-010092-uftc8inx 11861 11 % % NN cord-010092-uftc8inx 11861 12 ( ( -LRB- cord-010092-uftc8inx 11861 13 5 5 CD cord-010092-uftc8inx 11861 14 of of IN cord-010092-uftc8inx 11861 15 121,076 121,076 CD cord-010092-uftc8inx 11861 16 ) ) -RRB- cord-010092-uftc8inx 11861 17 and and CC cord-010092-uftc8inx 11861 18 0.12 0.12 CD cord-010092-uftc8inx 11861 19 % % NN cord-010092-uftc8inx 11861 20 were be VBD cord-010092-uftc8inx 11861 21 reported report VBN cord-010092-uftc8inx 11861 22 transfusion transfusion NN cord-010092-uftc8inx 11861 23 reactions reaction NNS cord-010092-uftc8inx 11861 24 ( ( -LRB- cord-010092-uftc8inx 11861 25 157 157 CD cord-010092-uftc8inx 11861 26 of of IN cord-010092-uftc8inx 11861 27 121,076 121,076 CD cord-010092-uftc8inx 11861 28 ) ) -RRB- cord-010092-uftc8inx 11861 29 . . . cord-010092-uftc8inx 11862 1 With with IN cord-010092-uftc8inx 11862 2 the the DT cord-010092-uftc8inx 11862 3 establishment establishment NN cord-010092-uftc8inx 11862 4 of of IN cord-010092-uftc8inx 11862 5 the the DT cord-010092-uftc8inx 11862 6 Hospital Hospital NNP cord-010092-uftc8inx 11862 7 Transfusion Transfusion NNP cord-010092-uftc8inx 11862 8 Board Board NNP cord-010092-uftc8inx 11862 9 and and CC cord-010092-uftc8inx 11862 10 with with IN cord-010092-uftc8inx 11862 11 the the DT cord-010092-uftc8inx 11862 12 increase increase NN cord-010092-uftc8inx 11862 13 of of IN cord-010092-uftc8inx 11862 14 collaboration collaboration NN cord-010092-uftc8inx 11862 15 with with IN cord-010092-uftc8inx 11862 16 the the DT cord-010092-uftc8inx 11862 17 Clinical Clinical NNP cord-010092-uftc8inx 11862 18 Center Center NNP cord-010092-uftc8inx 11862 19 , , , cord-010092-uftc8inx 11862 20 significant significant JJ cord-010092-uftc8inx 11862 21 progress progress NN cord-010092-uftc8inx 11862 22 has have VBZ cord-010092-uftc8inx 11862 23 been be VBN cord-010092-uftc8inx 11862 24 made make VBN cord-010092-uftc8inx 11862 25 . . . cord-010092-uftc8inx 11863 1 It -PRON- PRP cord-010092-uftc8inx 11863 2 is be VBZ cord-010092-uftc8inx 11863 3 necessary necessary JJ cord-010092-uftc8inx 11863 4 to to TO cord-010092-uftc8inx 11863 5 increase increase VB cord-010092-uftc8inx 11863 6 awareness awareness NN cord-010092-uftc8inx 11863 7 among among IN cord-010092-uftc8inx 11863 8 clinicians clinician NNS cord-010092-uftc8inx 11863 9 in in IN cord-010092-uftc8inx 11863 10 regards regard NNS cord-010092-uftc8inx 11863 11 to to IN cord-010092-uftc8inx 11863 12 the the DT cord-010092-uftc8inx 11863 13 safe safe JJ cord-010092-uftc8inx 11863 14 transfusion transfusion NN cord-010092-uftc8inx 11863 15 practice practice NN cord-010092-uftc8inx 11863 16 . . . cord-010092-uftc8inx 11864 1 Reporting report VBG cord-010092-uftc8inx 11864 2 transfusion transfusion NN cord-010092-uftc8inx 11864 3 reactions reaction NNS cord-010092-uftc8inx 11864 4 should should MD cord-010092-uftc8inx 11864 5 be be VB cord-010092-uftc8inx 11864 6 a a DT cord-010092-uftc8inx 11864 7 mandatory mandatory JJ cord-010092-uftc8inx 11864 8 procedure procedure NN cord-010092-uftc8inx 11864 9 , , , cord-010092-uftc8inx 11864 10 a a DT cord-010092-uftc8inx 11864 11 path path NN cord-010092-uftc8inx 11864 12 to to IN cord-010092-uftc8inx 11864 13 the the DT cord-010092-uftc8inx 11864 14 proper proper JJ cord-010092-uftc8inx 11864 15 selection selection NN cord-010092-uftc8inx 11864 16 of of IN cord-010092-uftc8inx 11864 17 blood blood NN cord-010092-uftc8inx 11864 18 components component NNS cord-010092-uftc8inx 11864 19 , , , cord-010092-uftc8inx 11864 20 monitoring monitor VBG cord-010092-uftc8inx 11864 21 adverse adverse JJ cord-010092-uftc8inx 11864 22 reactions reaction NNS cord-010092-uftc8inx 11864 23 , , , cord-010092-uftc8inx 11864 24 and and CC cord-010092-uftc8inx 11864 25 for for IN cord-010092-uftc8inx 11864 26 us -PRON- PRP cord-010092-uftc8inx 11864 27 , , , cord-010092-uftc8inx 11864 28 transfusiologist transfusiologist NNP cord-010092-uftc8inx 11864 29 , , , cord-010092-uftc8inx 11864 30 guide guide VB cord-010092-uftc8inx 11864 31 to to IN cord-010092-uftc8inx 11864 32 the the DT cord-010092-uftc8inx 11864 33 safest safe JJS cord-010092-uftc8inx 11864 34 , , , cord-010092-uftc8inx 11864 35 most most RBS cord-010092-uftc8inx 11864 36 efficient efficient JJ cord-010092-uftc8inx 11864 37 blood blood NN cord-010092-uftc8inx 11864 38 components component NNS cord-010092-uftc8inx 11864 39 . . . cord-010092-uftc8inx 11865 1 J J NNP cord-010092-uftc8inx 11865 2 Garc Garc NNP cord-010092-uftc8inx 11865 3 ıa ıa VBZ cord-010092-uftc8inx 11865 4 - - : cord-010092-uftc8inx 11865 5 Gala Gala NNP cord-010092-uftc8inx 11865 6 , , , cord-010092-uftc8inx 11865 7 E E NNP cord-010092-uftc8inx 11865 8 Martinez Martinez NNP cord-010092-uftc8inx 11865 9 - - HYPH cord-010092-uftc8inx 11865 10 Revuelta Revuelta NNP cord-010092-uftc8inx 11865 11 , , , cord-010092-uftc8inx 11865 12 A a DT cord-010092-uftc8inx 11865 13 Caro Caro NNP cord-010092-uftc8inx 11865 14 - - HYPH cord-010092-uftc8inx 11865 15 G g NN cord-010092-uftc8inx 11865 16 omez omez NN cord-010092-uftc8inx 11865 17 , , , cord-010092-uftc8inx 11865 18 C C NNP cord-010092-uftc8inx 11865 19 Castañ Castañ NNP cord-010092-uftc8inx 11865 20 on on IN cord-010092-uftc8inx 11865 21 - - HYPH cord-010092-uftc8inx 11865 22 Fern Fern NNP cord-010092-uftc8inx 11865 23 andez andez NN cord-010092-uftc8inx 11866 1 and and CC cord-010092-uftc8inx 11866 2 I -PRON- PRP cord-010092-uftc8inx 11867 1 Fern Fern NNP cord-010092-uftc8inx 11867 2 andez andez NNP cord-010092-uftc8inx 11867 3 - - : cord-010092-uftc8inx 11867 4 Rodriguez Rodriguez NNP cord-010092-uftc8inx 11867 5 Hospital Hospital NNP cord-010092-uftc8inx 11867 6 Universitario Universitario NNP cord-010092-uftc8inx 11867 7 Central Central NNP cord-010092-uftc8inx 11867 8 de de NNP cord-010092-uftc8inx 11867 9 Asturias Asturias NNP cord-010092-uftc8inx 11867 10 , , , cord-010092-uftc8inx 11867 11 Oviedo Oviedo NNP cord-010092-uftc8inx 11868 1 , , , cord-010092-uftc8inx 11868 2 Spain Spain NNP cord-010092-uftc8inx 11868 3 Background Background NNP cord-010092-uftc8inx 11868 4 : : : cord-010092-uftc8inx 11869 1 Elderly elderly JJ cord-010092-uftc8inx 11869 2 patients patient NNS cord-010092-uftc8inx 11869 3 are be VBP cord-010092-uftc8inx 11869 4 the the DT cord-010092-uftc8inx 11869 5 main main JJ cord-010092-uftc8inx 11869 6 group group NN cord-010092-uftc8inx 11869 7 of of IN cord-010092-uftc8inx 11869 8 transfusion transfusion NN cord-010092-uftc8inx 11869 9 recipients recipient NNS cord-010092-uftc8inx 11869 10 in in IN cord-010092-uftc8inx 11869 11 our -PRON- PRP$ cord-010092-uftc8inx 11869 12 country country NN cord-010092-uftc8inx 11869 13 . . . cord-010092-uftc8inx 11870 1 Given give VBN cord-010092-uftc8inx 11870 2 their -PRON- PRP$ cord-010092-uftc8inx 11870 3 comorbidities comorbiditie NNS cord-010092-uftc8inx 11870 4 are be VBP cord-010092-uftc8inx 11870 5 a a DT cord-010092-uftc8inx 11870 6 risk risk NN cord-010092-uftc8inx 11870 7 group group NN cord-010092-uftc8inx 11870 8 for for IN cord-010092-uftc8inx 11870 9 the the DT cord-010092-uftc8inx 11870 10 development development NN cord-010092-uftc8inx 11870 11 complications complication NNS cord-010092-uftc8inx 11870 12 related relate VBN cord-010092-uftc8inx 11870 13 to to IN cord-010092-uftc8inx 11870 14 transfusion transfusion NN cord-010092-uftc8inx 11870 15 . . . cord-010092-uftc8inx 11871 1 Aims aim VBZ cord-010092-uftc8inx 11871 2 : : : cord-010092-uftc8inx 11872 1 Analyze analyze VB cord-010092-uftc8inx 11872 2 the the DT cord-010092-uftc8inx 11872 3 incidence incidence NN cord-010092-uftc8inx 11872 4 of of IN cord-010092-uftc8inx 11872 5 adverse adverse JJ cord-010092-uftc8inx 11872 6 effects effect NNS cord-010092-uftc8inx 11872 7 related relate VBN cord-010092-uftc8inx 11872 8 to to IN cord-010092-uftc8inx 11872 9 transfusion transfusion NN cord-010092-uftc8inx 11872 10 in in IN cord-010092-uftc8inx 11872 11 the the DT cord-010092-uftc8inx 11872 12 elderly elderly JJ cord-010092-uftc8inx 11872 13 population population NN cord-010092-uftc8inx 11872 14 and and CC cord-010092-uftc8inx 11872 15 to to TO cord-010092-uftc8inx 11872 16 assess assess VB cord-010092-uftc8inx 11872 17 what what WDT cord-010092-uftc8inx 11872 18 factors factor NNS cord-010092-uftc8inx 11872 19 may may MD cord-010092-uftc8inx 11872 20 influence influence VB cord-010092-uftc8inx 11872 21 its -PRON- PRP$ cord-010092-uftc8inx 11872 22 appearance appearance NN cord-010092-uftc8inx 11872 23 Methods method NNS cord-010092-uftc8inx 11872 24 : : : cord-010092-uftc8inx 11872 25 Transfusions transfusion NNS cord-010092-uftc8inx 11872 26 were be VBD cord-010092-uftc8inx 11872 27 reviewed review VBN cord-010092-uftc8inx 11872 28 in in IN cord-010092-uftc8inx 11872 29 patients patient NNS cord-010092-uftc8inx 11872 30 > > XX cord-010092-uftc8inx 11872 31 70 70 CD cord-010092-uftc8inx 11872 32 years year NNS cord-010092-uftc8inx 11872 33 old old JJ cord-010092-uftc8inx 11872 34 . . . cord-010092-uftc8inx 11873 1 The the DT cord-010092-uftc8inx 11873 2 variables variable NNS cord-010092-uftc8inx 11873 3 analyzed analyze VBN cord-010092-uftc8inx 11873 4 were be VBD cord-010092-uftc8inx 11873 5 : : : cord-010092-uftc8inx 11873 6 sex sex NN cord-010092-uftc8inx 11873 7 , , , cord-010092-uftc8inx 11873 8 age age NN cord-010092-uftc8inx 11873 9 , , , cord-010092-uftc8inx 11873 10 diagnosis diagnosis NN cord-010092-uftc8inx 11873 11 / / SYM cord-010092-uftc8inx 11873 12 reason reason NN cord-010092-uftc8inx 11873 13 for for IN cord-010092-uftc8inx 11873 14 transfusion transfusion NN cord-010092-uftc8inx 11873 15 , , , cord-010092-uftc8inx 11873 16 pre pre JJ cord-010092-uftc8inx 11873 17 - - JJ cord-010092-uftc8inx 11873 18 transfusion transfusion JJ cord-010092-uftc8inx 11873 19 hemoglobin hemoglobin NN cord-010092-uftc8inx 11873 20 ( ( -LRB- cord-010092-uftc8inx 11873 21 Hb Hb NNP cord-010092-uftc8inx 11873 22 ) ) -RRB- cord-010092-uftc8inx 11873 23 , , , cord-010092-uftc8inx 11873 24 number number NN cord-010092-uftc8inx 11873 25 of of IN cord-010092-uftc8inx 11873 26 transfused transfuse VBN cord-010092-uftc8inx 11873 27 units unit NNS cord-010092-uftc8inx 11873 28 , , , cord-010092-uftc8inx 11873 29 infusion infusion NN cord-010092-uftc8inx 11873 30 rate rate NN cord-010092-uftc8inx 11873 31 and and CC cord-010092-uftc8inx 11873 32 transfusion transfusion NN cord-010092-uftc8inx 11873 33 side side NN cord-010092-uftc8inx 11873 34 effects effect NNS cord-010092-uftc8inx 11873 35 , , , cord-010092-uftc8inx 11873 36 as as RB cord-010092-uftc8inx 11873 37 well well RB cord-010092-uftc8inx 11873 38 as as IN cord-010092-uftc8inx 11873 39 the the DT cord-010092-uftc8inx 11873 40 measures measure NNS cord-010092-uftc8inx 11873 41 used use VBN cord-010092-uftc8inx 11873 42 to to TO cord-010092-uftc8inx 11873 43 prevent prevent VB cord-010092-uftc8inx 11873 44 or or CC cord-010092-uftc8inx 11873 45 treat treat VB cord-010092-uftc8inx 11873 46 the the DT cord-010092-uftc8inx 11873 47 transfusions transfusion NNS cord-010092-uftc8inx 11873 48 . . . cord-010092-uftc8inx 11874 1 effects effect NNS cord-010092-uftc8inx 11874 2 of of IN cord-010092-uftc8inx 11874 3 circulatory circulatory JJ cord-010092-uftc8inx 11874 4 overload overload NN cord-010092-uftc8inx 11874 5 Results result NNS cord-010092-uftc8inx 11874 6 : : : cord-010092-uftc8inx 11874 7 A a DT cord-010092-uftc8inx 11874 8 total total NN cord-010092-uftc8inx 11874 9 of of IN cord-010092-uftc8inx 11874 10 93 93 CD cord-010092-uftc8inx 11874 11 patients patient NNS cord-010092-uftc8inx 11874 12 were be VBD cord-010092-uftc8inx 11874 13 analyzed analyze VBN cord-010092-uftc8inx 11874 14 ( ( -LRB- cord-010092-uftc8inx 11874 15 48 48 CD cord-010092-uftc8inx 11874 16 women woman NNS cord-010092-uftc8inx 11874 17 , , , cord-010092-uftc8inx 11874 18 45 45 CD cord-010092-uftc8inx 11874 19 men man NNS cord-010092-uftc8inx 11874 20 ) ) -RRB- cord-010092-uftc8inx 11874 21 , , , cord-010092-uftc8inx 11874 22 with with IN cord-010092-uftc8inx 11874 23 a a DT cord-010092-uftc8inx 11874 24 median median JJ cord-010092-uftc8inx 11874 25 age age NN cord-010092-uftc8inx 11874 26 of of IN cord-010092-uftc8inx 11874 27 86 86 CD cord-010092-uftc8inx 11874 28 years year NNS cord-010092-uftc8inx 11874 29 ( ( -LRB- cord-010092-uftc8inx 11874 30 70 70 CD cord-010092-uftc8inx 11874 31 - - SYM cord-010092-uftc8inx 11874 32 97 97 CD cord-010092-uftc8inx 11874 33 ) ) -RRB- cord-010092-uftc8inx 11874 34 . . . cord-010092-uftc8inx 11875 1 In in IN cord-010092-uftc8inx 11875 2 total total NN cord-010092-uftc8inx 11875 3 , , , cord-010092-uftc8inx 11875 4 189 189 CD cord-010092-uftc8inx 11875 5 CH CH NNP cord-010092-uftc8inx 11875 6 were be VBD cord-010092-uftc8inx 11875 7 transfused transfuse VBN cord-010092-uftc8inx 11875 8 . . . cord-010092-uftc8inx 11876 1 70 70 CD cord-010092-uftc8inx 11876 2 patients patient NNS cord-010092-uftc8inx 11876 3 received receive VBD cord-010092-uftc8inx 11876 4 2 2 CD cord-010092-uftc8inx 11876 5 CH ch NN cord-010092-uftc8inx 11876 6 , , , cord-010092-uftc8inx 11876 7 3 3 CD cord-010092-uftc8inx 11876 8 patients patient NNS cord-010092-uftc8inx 11876 9 3 3 CD cord-010092-uftc8inx 11876 10 CH CH NNP cord-010092-uftc8inx 11876 11 , , , cord-010092-uftc8inx 11876 12 10 10 CD cord-010092-uftc8inx 11876 13 patients patient NNS cord-010092-uftc8inx 11876 14 received receive VBD cord-010092-uftc8inx 11876 15 1 1 CD cord-010092-uftc8inx 11876 16 CH ch NN cord-010092-uftc8inx 11876 17 . . . cord-010092-uftc8inx 11877 1 10 10 CD cord-010092-uftc8inx 11877 2 patients patient NNS cord-010092-uftc8inx 11877 3 were be VBD cord-010092-uftc8inx 11877 4 transfused transfuse VBN cord-010092-uftc8inx 11877 5 at at IN cord-010092-uftc8inx 11877 6 two two CD cord-010092-uftc8inx 11877 7 different different JJ cord-010092-uftc8inx 11877 8 times time NNS cord-010092-uftc8inx 11877 9 . . . cord-010092-uftc8inx 11878 1 The the DT cord-010092-uftc8inx 11878 2 median median JJ cord-010092-uftc8inx 11878 3 Hb Hb NNP cord-010092-uftc8inx 11878 4 prior prior RB cord-010092-uftc8inx 11878 5 to to IN cord-010092-uftc8inx 11878 6 transfusion transfusion NN cord-010092-uftc8inx 11878 7 was be VBD cord-010092-uftc8inx 11878 8 7.6 7.6 CD cord-010092-uftc8inx 11878 9 g g NN cord-010092-uftc8inx 11878 10 / / SYM cord-010092-uftc8inx 11878 11 dL. dl. NN cord-010092-uftc8inx 11879 1 In in IN cord-010092-uftc8inx 11879 2 the the DT cord-010092-uftc8inx 11879 3 patients patient NNS cord-010092-uftc8inx 11879 4 who who WP cord-010092-uftc8inx 11879 5 received receive VBD cord-010092-uftc8inx 11879 6 2 2 CD cord-010092-uftc8inx 11879 7 CH CH NNP cord-010092-uftc8inx 11879 8 was be VBD cord-010092-uftc8inx 11879 9 7.5 7.5 CD cord-010092-uftc8inx 11879 10 g g NN cord-010092-uftc8inx 11879 11 / / SYM cord-010092-uftc8inx 11879 12 dL dl NN cord-010092-uftc8inx 11879 13 , , , cord-010092-uftc8inx 11879 14 those those DT cord-010092-uftc8inx 11879 15 who who WP cord-010092-uftc8inx 11879 16 received receive VBD cord-010092-uftc8inx 11879 17 3 3 CD cord-010092-uftc8inx 11879 18 CH ch NN cord-010092-uftc8inx 11879 19 : : : cord-010092-uftc8inx 11879 20 6 6 CD cord-010092-uftc8inx 11879 21 g g NN cord-010092-uftc8inx 11879 22 / / SYM cord-010092-uftc8inx 11879 23 dL dl NN cord-010092-uftc8inx 11879 24 and and CC cord-010092-uftc8inx 11879 25 those those DT cord-010092-uftc8inx 11879 26 who who WP cord-010092-uftc8inx 11879 27 received receive VBD cord-010092-uftc8inx 11879 28 1 1 CD cord-010092-uftc8inx 11879 29 CH ch NN cord-010092-uftc8inx 11879 30 : : : cord-010092-uftc8inx 11879 31 7.75 7.75 CD cord-010092-uftc8inx 11879 32 g g NN cord-010092-uftc8inx 11879 33 / / SYM cord-010092-uftc8inx 11879 34 dL. dl. NN cord-010092-uftc8inx 11880 1 The the DT cord-010092-uftc8inx 11880 2 infusion infusion NN cord-010092-uftc8inx 11880 3 time time NN cord-010092-uftc8inx 11880 4 could could MD cord-010092-uftc8inx 11880 5 be be VB cord-010092-uftc8inx 11880 6 estimated estimate VBN cord-010092-uftc8inx 11880 7 in in IN cord-010092-uftc8inx 11880 8 84 84 CD cord-010092-uftc8inx 11880 9 % % NN cord-010092-uftc8inx 11880 10 of of IN cord-010092-uftc8inx 11880 11 the the DT cord-010092-uftc8inx 11880 12 patients patient NNS cord-010092-uftc8inx 11880 13 . . . cord-010092-uftc8inx 11881 1 In in IN cord-010092-uftc8inx 11881 2 those those DT cord-010092-uftc8inx 11881 3 who who WP cord-010092-uftc8inx 11881 4 received receive VBD cord-010092-uftc8inx 11881 5 2 2 CD cord-010092-uftc8inx 11881 6 CH CH NNP cord-010092-uftc8inx 11881 7 was be VBD cord-010092-uftc8inx 11881 8 223.62 223.62 CD cord-010092-uftc8inx 11881 9 min min NN cord-010092-uftc8inx 11881 10 ; ; : cord-010092-uftc8inx 11881 11 249.33 249.33 CD cord-010092-uftc8inx 11881 12 min min NN cord-010092-uftc8inx 11881 13 in in IN cord-010092-uftc8inx 11881 14 those those DT cord-010092-uftc8inx 11881 15 who who WP cord-010092-uftc8inx 11881 16 received receive VBD cord-010092-uftc8inx 11881 17 3 3 CD cord-010092-uftc8inx 11881 18 CH CH NNP cord-010092-uftc8inx 11881 19 and and CC cord-010092-uftc8inx 11881 20 109.75 109.75 CD cord-010092-uftc8inx 11881 21 min min NN cord-010092-uftc8inx 11881 22 in in IN cord-010092-uftc8inx 11881 23 those those DT cord-010092-uftc8inx 11881 24 who who WP cord-010092-uftc8inx 11881 25 received receive VBD cord-010092-uftc8inx 11881 26 1 1 CD cord-010092-uftc8inx 11881 27 CH ch NN cord-010092-uftc8inx 11881 28 . . . cord-010092-uftc8inx 11882 1 13 13 CD cord-010092-uftc8inx 11882 2 patients patient NNS cord-010092-uftc8inx 11882 3 ( ( -LRB- cord-010092-uftc8inx 11882 4 14 14 CD cord-010092-uftc8inx 11882 5 % % NN cord-010092-uftc8inx 11882 6 of of IN cord-010092-uftc8inx 11882 7 the the DT cord-010092-uftc8inx 11882 8 total total NN cord-010092-uftc8inx 11882 9 ) ) -RRB- cord-010092-uftc8inx 11882 10 suffered suffer VBD cord-010092-uftc8inx 11882 11 some some DT cord-010092-uftc8inx 11882 12 type type NN cord-010092-uftc8inx 11882 13 of of IN cord-010092-uftc8inx 11882 14 adverse adverse JJ cord-010092-uftc8inx 11882 15 effect effect NN cord-010092-uftc8inx 11882 16 related relate VBN cord-010092-uftc8inx 11882 17 to to IN cord-010092-uftc8inx 11882 18 the the DT cord-010092-uftc8inx 11882 19 transfusion transfusion NN cord-010092-uftc8inx 11882 20 . . . cord-010092-uftc8inx 11883 1 In in IN cord-010092-uftc8inx 11883 2 9 9 CD cord-010092-uftc8inx 11883 3 patients patient NNS cord-010092-uftc8inx 11883 4 there there EX cord-010092-uftc8inx 11883 5 was be VBD cord-010092-uftc8inx 11883 6 an an DT cord-010092-uftc8inx 11883 7 increase increase NN cord-010092-uftc8inx 11883 8 in in IN cord-010092-uftc8inx 11883 9 posterior posterior JJ cord-010092-uftc8inx 11883 10 TA TA NNP cord-010092-uftc8inx 11883 11 , , , cord-010092-uftc8inx 11883 12 in in IN cord-010092-uftc8inx 11883 13 2 2 CD cord-010092-uftc8inx 11883 14 an an DT cord-010092-uftc8inx 11883 15 increase increase NN cord-010092-uftc8inx 11883 16 in in IN cord-010092-uftc8inx 11883 17 HR HR NNP cord-010092-uftc8inx 11883 18 , , , cord-010092-uftc8inx 11883 19 in in IN cord-010092-uftc8inx 11883 20 1 1 CD cord-010092-uftc8inx 11883 21 an an DT cord-010092-uftc8inx 11883 22 episode episode NN cord-010092-uftc8inx 11883 23 of of IN cord-010092-uftc8inx 11883 24 hypotension hypotension NN cord-010092-uftc8inx 11883 25 and and CC cord-010092-uftc8inx 11883 26 in in IN cord-010092-uftc8inx 11883 27 another another DT cord-010092-uftc8inx 11883 28 one one CD cord-010092-uftc8inx 11883 29 episode episode NN cord-010092-uftc8inx 11883 30 of of IN cord-010092-uftc8inx 11883 31 acute acute JJ cord-010092-uftc8inx 11883 32 respiratory respiratory JJ cord-010092-uftc8inx 11883 33 failure failure NN cord-010092-uftc8inx 11883 34 . . . cord-010092-uftc8inx 11884 1 70 70 CD cord-010092-uftc8inx 11884 2 % % NN cord-010092-uftc8inx 11884 3 of of IN cord-010092-uftc8inx 11884 4 those those DT cord-010092-uftc8inx 11884 5 who who WP cord-010092-uftc8inx 11884 6 had have VBD cord-010092-uftc8inx 11884 7 an an DT cord-010092-uftc8inx 11884 8 adverse adverse JJ cord-010092-uftc8inx 11884 9 effect effect NN cord-010092-uftc8inx 11884 10 were be VBD cord-010092-uftc8inx 11884 11 older old JJR cord-010092-uftc8inx 11884 12 than than IN cord-010092-uftc8inx 11884 13 85 85 CD cord-010092-uftc8inx 11884 14 years year NNS cord-010092-uftc8inx 11884 15 . . . cord-010092-uftc8inx 11885 1 Patients patient NNS cord-010092-uftc8inx 11885 2 with with IN cord-010092-uftc8inx 11885 3 AHT AHT NNP cord-010092-uftc8inx 11885 4 after after IN cord-010092-uftc8inx 11885 5 transfusion transfusion NN cord-010092-uftc8inx 11885 6 , , , cord-010092-uftc8inx 11885 7 75 75 CD cord-010092-uftc8inx 11885 8 % % NN cord-010092-uftc8inx 11885 9 received receive VBD cord-010092-uftc8inx 11885 10 2 2 CD cord-010092-uftc8inx 11885 11 CH ch NN cord-010092-uftc8inx 11885 12 and and CC cord-010092-uftc8inx 11885 13 the the DT cord-010092-uftc8inx 11885 14 remainder remainder NN cord-010092-uftc8inx 11885 15 1 1 CD cord-010092-uftc8inx 11885 16 CH ch NN cord-010092-uftc8inx 11885 17 . . . cord-010092-uftc8inx 11886 1 Among among IN cord-010092-uftc8inx 11886 2 their -PRON- PRP$ cord-010092-uftc8inx 11886 3 background background NN cord-010092-uftc8inx 11886 4 , , , cord-010092-uftc8inx 11886 5 66 66 CD cord-010092-uftc8inx 11886 6 % % NN cord-010092-uftc8inx 11886 7 had have VBD cord-010092-uftc8inx 11886 8 a a DT cord-010092-uftc8inx 11886 9 history history NN cord-010092-uftc8inx 11886 10 of of IN cord-010092-uftc8inx 11886 11 ischemic ischemic JJ cord-010092-uftc8inx 11886 12 heart heart NN cord-010092-uftc8inx 11886 13 disease disease NN cord-010092-uftc8inx 11886 14 . . . cord-010092-uftc8inx 11887 1 33 33 CD cord-010092-uftc8inx 11887 2 % % NN cord-010092-uftc8inx 11887 3 also also RB cord-010092-uftc8inx 11887 4 had have VBD cord-010092-uftc8inx 11887 5 a a DT cord-010092-uftc8inx 11887 6 positive positive JJ cord-010092-uftc8inx 11887 7 balance balance NN cord-010092-uftc8inx 11887 8 . . . cord-010092-uftc8inx 11888 1 The the DT cord-010092-uftc8inx 11888 2 average average JJ cord-010092-uftc8inx 11888 3 previous previous JJ cord-010092-uftc8inx 11888 4 BP BP NNP cord-010092-uftc8inx 11888 5 was be VBD cord-010092-uftc8inx 11888 6 137/65 137/65 CD cord-010092-uftc8inx 11888 7 mmHg mmHg NNS cord-010092-uftc8inx 11888 8 and and CC cord-010092-uftc8inx 11888 9 the the DT cord-010092-uftc8inx 11888 10 subsequent subsequent JJ cord-010092-uftc8inx 11888 11 one one NN cord-010092-uftc8inx 11888 12 was be VBD cord-010092-uftc8inx 11888 13 182/72 182/72 CD cord-010092-uftc8inx 11888 14 mmHg mmHg NNS cord-010092-uftc8inx 11888 15 . . . cord-010092-uftc8inx 11889 1 55 55 CD cord-010092-uftc8inx 11889 2 % % NN cord-010092-uftc8inx 11889 3 of of IN cord-010092-uftc8inx 11889 4 patients patient NNS cord-010092-uftc8inx 11889 5 did do VBD cord-010092-uftc8inx 11889 6 not not RB cord-010092-uftc8inx 11889 7 receive receive VB cord-010092-uftc8inx 11889 8 diuretic diuretic JJ cord-010092-uftc8inx 11889 9 treatment treatment NN cord-010092-uftc8inx 11889 10 . . . cord-010092-uftc8inx 11890 1 In in IN cord-010092-uftc8inx 11890 2 the the DT cord-010092-uftc8inx 11890 3 case case NN cord-010092-uftc8inx 11890 4 of of IN cord-010092-uftc8inx 11890 5 the the DT cord-010092-uftc8inx 11890 6 patient patient NN cord-010092-uftc8inx 11890 7 with with IN cord-010092-uftc8inx 11890 8 acute acute JJ cord-010092-uftc8inx 11890 9 respiratory respiratory JJ cord-010092-uftc8inx 11890 10 failure failure NN cord-010092-uftc8inx 11890 11 was be VBD cord-010092-uftc8inx 11890 12 in in IN cord-010092-uftc8inx 11890 13 oligoanuria oligoanuria NNP cord-010092-uftc8inx 11890 14 , , , cord-010092-uftc8inx 11890 15 with with IN cord-010092-uftc8inx 11890 16 positive positive JJ cord-010092-uftc8inx 11890 17 balances balance NNS cord-010092-uftc8inx 11890 18 . . . cord-010092-uftc8inx 11891 1 2 2 LS cord-010092-uftc8inx 11891 2 CH CH NNP cord-010092-uftc8inx 11891 3 was be VBD cord-010092-uftc8inx 11891 4 transfused transfuse VBN cord-010092-uftc8inx 11891 5 in in IN cord-010092-uftc8inx 11891 6 total total NN cord-010092-uftc8inx 11891 7 . . . cord-010092-uftc8inx 11892 1 She -PRON- PRP cord-010092-uftc8inx 11892 2 was be VBD cord-010092-uftc8inx 11892 3 treated treat VBN cord-010092-uftc8inx 11892 4 with with IN cord-010092-uftc8inx 11892 5 oxygen oxygen NN cord-010092-uftc8inx 11892 6 therapy therapy NN cord-010092-uftc8inx 11892 7 and and CC cord-010092-uftc8inx 11892 8 with with IN cord-010092-uftc8inx 11892 9 intensification intensification NN cord-010092-uftc8inx 11892 10 of of IN cord-010092-uftc8inx 11892 11 the the DT cord-010092-uftc8inx 11892 12 diuretic diuretic JJ cord-010092-uftc8inx 11892 13 treatment treatment NN cord-010092-uftc8inx 11892 14 , , , cord-010092-uftc8inx 11892 15 recovering recover VBG cord-010092-uftc8inx 11892 16 later later RB cord-010092-uftc8inx 11892 17 . . . cord-010092-uftc8inx 11893 1 Summary Summary NNP cord-010092-uftc8inx 11893 2 / / SYM cord-010092-uftc8inx 11893 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 11893 4 : : : cord-010092-uftc8inx 11894 1 -Patients -patient NNS cord-010092-uftc8inx 11894 2 > > XX cord-010092-uftc8inx 11894 3 85 85 CD cord-010092-uftc8inx 11894 4 years year NNS cord-010092-uftc8inx 11894 5 have have VBP cord-010092-uftc8inx 11894 6 a a DT cord-010092-uftc8inx 11894 7 higher high JJR cord-010092-uftc8inx 11894 8 risk risk NN cord-010092-uftc8inx 11894 9 of of IN cord-010092-uftc8inx 11894 10 suffering suffer VBG cord-010092-uftc8inx 11894 11 some some DT cord-010092-uftc8inx 11894 12 type type NN cord-010092-uftc8inx 11894 13 of of IN cord-010092-uftc8inx 11894 14 adverse adverse JJ cord-010092-uftc8inx 11894 15 effect effect NN cord-010092-uftc8inx 11894 16 related relate VBN cord-010092-uftc8inx 11894 17 to to IN cord-010092-uftc8inx 11894 18 transfusion transfusion NN cord-010092-uftc8inx 11894 19 because because IN cord-010092-uftc8inx 11894 20 they -PRON- PRP cord-010092-uftc8inx 11894 21 have have VBP cord-010092-uftc8inx 11894 22 pre pre VBN cord-010092-uftc8inx 11894 23 - - JJ cord-010092-uftc8inx 11894 24 existing existing JJ cord-010092-uftc8inx 11894 25 risk risk NN cord-010092-uftc8inx 11894 26 factors factor NNS cord-010092-uftc8inx 11894 27 such such JJ cord-010092-uftc8inx 11894 28 as as IN cord-010092-uftc8inx 11894 29 ischemic ischemic JJ cord-010092-uftc8inx 11894 30 heart heart NN cord-010092-uftc8inx 11894 31 disease disease NN cord-010092-uftc8inx 11894 32 or or CC cord-010092-uftc8inx 11894 33 heart heart NN cord-010092-uftc8inx 11894 34 failure failure NN cord-010092-uftc8inx 11894 35 . . . cord-010092-uftc8inx 11895 1 -We -We : cord-010092-uftc8inx 11895 2 see see VB cord-010092-uftc8inx 11895 3 that that IN cord-010092-uftc8inx 11895 4 the the DT cord-010092-uftc8inx 11895 5 risk risk NN cord-010092-uftc8inx 11895 6 of of IN cord-010092-uftc8inx 11895 7 suffering suffer VBG cord-010092-uftc8inx 11895 8 some some DT cord-010092-uftc8inx 11895 9 type type NN cord-010092-uftc8inx 11895 10 of of IN cord-010092-uftc8inx 11895 11 adverse adverse JJ cord-010092-uftc8inx 11895 12 effect effect NN cord-010092-uftc8inx 11895 13 in in IN cord-010092-uftc8inx 11895 14 the the DT cord-010092-uftc8inx 11895 15 elderly elderly JJ cord-010092-uftc8inx 11895 16 population population NN cord-010092-uftc8inx 11895 17 is be VBZ cord-010092-uftc8inx 11895 18 greater great JJR cord-010092-uftc8inx 11895 19 when when WRB cord-010092-uftc8inx 11895 20 we -PRON- PRP cord-010092-uftc8inx 11895 21 transfuse transfuse VBP cord-010092-uftc8inx 11895 22 2CH 2ch CD cord-010092-uftc8inx 11895 23 than than IN cord-010092-uftc8inx 11895 24 1CH 1CH NNP cord-010092-uftc8inx 11895 25 . . . cord-010092-uftc8inx 11896 1 -We -We : cord-010092-uftc8inx 11896 2 have have VBP cord-010092-uftc8inx 11896 3 appreciated appreciate VBN cord-010092-uftc8inx 11896 4 that that IN cord-010092-uftc8inx 11896 5 in in IN cord-010092-uftc8inx 11896 6 those those DT cord-010092-uftc8inx 11896 7 patients patient NNS cord-010092-uftc8inx 11896 8 receiving receive VBG cord-010092-uftc8inx 11896 9 3CH 3ch CD cord-010092-uftc8inx 11896 10 , , , cord-010092-uftc8inx 11896 11 the the DT cord-010092-uftc8inx 11896 12 infusion infusion NN cord-010092-uftc8inx 11896 13 rate rate NN cord-010092-uftc8inx 11896 14 is be VBZ cord-010092-uftc8inx 11896 15 higher high JJR cord-010092-uftc8inx 11896 16 . . . cord-010092-uftc8inx 11897 1 -The -The : cord-010092-uftc8inx 11897 2 study study NN cord-010092-uftc8inx 11897 3 highlights highlight VBZ cord-010092-uftc8inx 11897 4 the the DT cord-010092-uftc8inx 11897 5 lack lack NN cord-010092-uftc8inx 11897 6 of of IN cord-010092-uftc8inx 11897 7 methods method NNS cord-010092-uftc8inx 11897 8 to to TO cord-010092-uftc8inx 11897 9 prevent prevent VB cord-010092-uftc8inx 11897 10 the the DT cord-010092-uftc8inx 11897 11 development development NN cord-010092-uftc8inx 11897 12 of of IN cord-010092-uftc8inx 11897 13 circulatory circulatory JJ cord-010092-uftc8inx 11897 14 overload overload NN cord-010092-uftc8inx 11897 15 . . . cord-010092-uftc8inx 11898 1 Background background NN cord-010092-uftc8inx 11898 2 : : : cord-010092-uftc8inx 11899 1 Iron iron NN cord-010092-uftc8inx 11899 2 deficiency deficiency NN cord-010092-uftc8inx 11899 3 anemia anemia NN cord-010092-uftc8inx 11899 4 is be VBZ cord-010092-uftc8inx 11899 5 the the DT cord-010092-uftc8inx 11899 6 commonest common JJS cord-010092-uftc8inx 11899 7 cause cause NN cord-010092-uftc8inx 11899 8 of of IN cord-010092-uftc8inx 11899 9 anemia anemia NN cord-010092-uftc8inx 11899 10 worldwide worldwide RB cord-010092-uftc8inx 11899 11 . . . cord-010092-uftc8inx 11900 1 Weakness weakness NN cord-010092-uftc8inx 11900 2 , , , cord-010092-uftc8inx 11900 3 fatigue fatigue NN cord-010092-uftc8inx 11900 4 , , , cord-010092-uftc8inx 11900 5 reduced reduce VBN cord-010092-uftc8inx 11900 6 physical physical JJ cord-010092-uftc8inx 11900 7 activity activity NN cord-010092-uftc8inx 11900 8 and and CC cord-010092-uftc8inx 11900 9 difficulty difficulty NN cord-010092-uftc8inx 11900 10 in in IN cord-010092-uftc8inx 11900 11 concentration concentration NN cord-010092-uftc8inx 11900 12 are be VBP cord-010092-uftc8inx 11900 13 the the DT cord-010092-uftc8inx 11900 14 symptoms symptom NNS cord-010092-uftc8inx 11900 15 which which WDT cord-010092-uftc8inx 11900 16 are be VBP cord-010092-uftc8inx 11900 17 associated associate VBN cord-010092-uftc8inx 11900 18 with with IN cord-010092-uftc8inx 11900 19 its -PRON- PRP$ cord-010092-uftc8inx 11900 20 deficiency deficiency NN cord-010092-uftc8inx 11900 21 . . . cord-010092-uftc8inx 11901 1 The the DT cord-010092-uftc8inx 11901 2 forefront forefront JJ cord-010092-uftc8inx 11901 3 treatment treatment NN cord-010092-uftc8inx 11901 4 available available JJ cord-010092-uftc8inx 11901 5 is be VBZ cord-010092-uftc8inx 11901 6 oral oral JJ cord-010092-uftc8inx 11901 7 iron iron NN cord-010092-uftc8inx 11901 8 replacement replacement NN cord-010092-uftc8inx 11901 9 therapy therapy NN cord-010092-uftc8inx 11901 10 which which WDT cord-010092-uftc8inx 11901 11 is be VBZ cord-010092-uftc8inx 11901 12 convenient convenient JJ cord-010092-uftc8inx 11901 13 , , , cord-010092-uftc8inx 11901 14 cost cost VBD cord-010092-uftc8inx 11901 15 effective effective JJ cord-010092-uftc8inx 11901 16 and and CC cord-010092-uftc8inx 11901 17 has have VBZ cord-010092-uftc8inx 11901 18 substantial substantial JJ cord-010092-uftc8inx 11901 19 outcome outcome NN cord-010092-uftc8inx 11901 20 . . . cord-010092-uftc8inx 11902 1 Another another DT cord-010092-uftc8inx 11902 2 option option NN cord-010092-uftc8inx 11902 3 is be VBZ cord-010092-uftc8inx 11902 4 intravenous intravenous JJ cord-010092-uftc8inx 11902 5 ( ( -LRB- cord-010092-uftc8inx 11902 6 I i NN cord-010092-uftc8inx 11902 7 / / SYM cord-010092-uftc8inx 11902 8 V v NN cord-010092-uftc8inx 11902 9 ) ) -RRB- cord-010092-uftc8inx 11902 10 iron iron NN cord-010092-uftc8inx 11902 11 when when WRB cord-010092-uftc8inx 11902 12 oral oral JJ cord-010092-uftc8inx 11902 13 is be VBZ cord-010092-uftc8inx 11902 14 not not RB cord-010092-uftc8inx 11902 15 tolerable tolerable JJ cord-010092-uftc8inx 11902 16 . . . cord-010092-uftc8inx 11903 1 Despite despite IN cord-010092-uftc8inx 11903 2 of of IN cord-010092-uftc8inx 11903 3 potential potential JJ cord-010092-uftc8inx 11903 4 transfusion transfusion NN cord-010092-uftc8inx 11903 5 associated associate VBD cord-010092-uftc8inx 11903 6 hazards hazard NNS cord-010092-uftc8inx 11903 7 and and CC cord-010092-uftc8inx 11903 8 limited limited JJ cord-010092-uftc8inx 11903 9 availability availability NN cord-010092-uftc8inx 11903 10 of of IN cord-010092-uftc8inx 11903 11 blood blood NN cord-010092-uftc8inx 11903 12 due due IN cord-010092-uftc8inx 11903 13 to to IN cord-010092-uftc8inx 11903 14 shortage shortage NN cord-010092-uftc8inx 11903 15 of of IN cord-010092-uftc8inx 11903 16 voluntary voluntary JJ cord-010092-uftc8inx 11903 17 blood blood NN cord-010092-uftc8inx 11903 18 donations donation NNS cord-010092-uftc8inx 11903 19 , , , cord-010092-uftc8inx 11903 20 it -PRON- PRP cord-010092-uftc8inx 11903 21 is be VBZ cord-010092-uftc8inx 11903 22 insisted insist VBN cord-010092-uftc8inx 11903 23 by by IN cord-010092-uftc8inx 11903 24 the the DT cord-010092-uftc8inx 11903 25 patients patient NNS cord-010092-uftc8inx 11903 26 prior prior RB cord-010092-uftc8inx 11903 27 to to IN cord-010092-uftc8inx 11903 28 iron iron NN cord-010092-uftc8inx 11903 29 therapy therapy NN cord-010092-uftc8inx 11903 30 . . . cord-010092-uftc8inx 11904 1 Aims aim VBZ cord-010092-uftc8inx 11904 2 : : : cord-010092-uftc8inx 11905 1 The the DT cord-010092-uftc8inx 11905 2 aim aim NN cord-010092-uftc8inx 11905 3 of of IN cord-010092-uftc8inx 11905 4 conducting conduct VBG cord-010092-uftc8inx 11905 5 this this DT cord-010092-uftc8inx 11905 6 study study NN cord-010092-uftc8inx 11905 7 was be VBD cord-010092-uftc8inx 11905 8 to to TO cord-010092-uftc8inx 11905 9 observe observe VB cord-010092-uftc8inx 11905 10 the the DT cord-010092-uftc8inx 11905 11 impact impact NN cord-010092-uftc8inx 11905 12 of of IN cord-010092-uftc8inx 11905 13 administration administration NN cord-010092-uftc8inx 11905 14 of of IN cord-010092-uftc8inx 11905 15 oral oral JJ cord-010092-uftc8inx 11905 16 iron iron NN cord-010092-uftc8inx 11905 17 , , , cord-010092-uftc8inx 11905 18 I i NN cord-010092-uftc8inx 11905 19 / / SYM cord-010092-uftc8inx 11905 20 V v NN cord-010092-uftc8inx 11905 21 iron iron NN cord-010092-uftc8inx 11905 22 and and CC cord-010092-uftc8inx 11905 23 transfusion transfusion NN cord-010092-uftc8inx 11905 24 on on IN cord-010092-uftc8inx 11905 25 hemoglobin hemoglobin NN cord-010092-uftc8inx 11905 26 levels level NNS cord-010092-uftc8inx 11905 27 in in IN cord-010092-uftc8inx 11905 28 patients patient NNS cord-010092-uftc8inx 11905 29 presented present VBN cord-010092-uftc8inx 11905 30 with with IN cord-010092-uftc8inx 11905 31 iron iron NN cord-010092-uftc8inx 11905 32 deficiency deficiency NN cord-010092-uftc8inx 11905 33 anemia anemia NN cord-010092-uftc8inx 11905 34 . . . cord-010092-uftc8inx 11906 1 Methods method NNS cord-010092-uftc8inx 11906 2 : : : cord-010092-uftc8inx 11906 3 This this DT cord-010092-uftc8inx 11906 4 was be VBD cord-010092-uftc8inx 11906 5 an an DT cord-010092-uftc8inx 11906 6 observational observational JJ cord-010092-uftc8inx 11906 7 study study NN cord-010092-uftc8inx 11906 8 carried carry VBN cord-010092-uftc8inx 11906 9 out out RP cord-010092-uftc8inx 11906 10 at at IN cord-010092-uftc8inx 11906 11 NIBD NIBD NNP cord-010092-uftc8inx 11906 12 and and CC cord-010092-uftc8inx 11906 13 BMT BMT NNP cord-010092-uftc8inx 11906 14 , , , cord-010092-uftc8inx 11906 15 PECHS PECHS NNP cord-010092-uftc8inx 11906 16 campus campus NN cord-010092-uftc8inx 11906 17 , , , cord-010092-uftc8inx 11906 18 Karachi Karachi NNP cord-010092-uftc8inx 11906 19 , , , cord-010092-uftc8inx 11906 20 Pakistan Pakistan NNP cord-010092-uftc8inx 11906 21 from from IN cord-010092-uftc8inx 11906 22 February February NNP cord-010092-uftc8inx 11906 23 2018 2018 CD cord-010092-uftc8inx 11906 24 to to IN cord-010092-uftc8inx 11906 25 December December NNP cord-010092-uftc8inx 11906 26 2018 2018 CD cord-010092-uftc8inx 11906 27 . . . cord-010092-uftc8inx 11907 1 The the DT cord-010092-uftc8inx 11907 2 study study NN cord-010092-uftc8inx 11907 3 was be VBD cord-010092-uftc8inx 11907 4 approved approve VBN cord-010092-uftc8inx 11907 5 by by IN cord-010092-uftc8inx 11907 6 the the DT cord-010092-uftc8inx 11907 7 institutional institutional NNP cord-010092-uftc8inx 11907 8 review review NNP cord-010092-uftc8inx 11907 9 board board NNP cord-010092-uftc8inx 11907 10 . . . cord-010092-uftc8inx 11908 1 Diagnosed diagnosed JJ cord-010092-uftc8inx 11908 2 IDA IDA NNP cord-010092-uftc8inx 11908 3 patients patient NNS cord-010092-uftc8inx 11908 4 presented present VBN cord-010092-uftc8inx 11908 5 at at IN cord-010092-uftc8inx 11908 6 our -PRON- PRP$ cord-010092-uftc8inx 11908 7 hospital hospital NN cord-010092-uftc8inx 11908 8 were be VBD cord-010092-uftc8inx 11908 9 recruited recruit VBN cord-010092-uftc8inx 11908 10 for for IN cord-010092-uftc8inx 11908 11 analysis analysis NN cord-010092-uftc8inx 11908 12 who who WP cord-010092-uftc8inx 11908 13 were be VBD cord-010092-uftc8inx 11908 14 given give VBN cord-010092-uftc8inx 11908 15 oral oral JJ cord-010092-uftc8inx 11908 16 iron iron NN cord-010092-uftc8inx 11908 17 , , , cord-010092-uftc8inx 11908 18 I i NN cord-010092-uftc8inx 11908 19 / / SYM cord-010092-uftc8inx 11908 20 V v NN cord-010092-uftc8inx 11908 21 iron iron NN cord-010092-uftc8inx 11908 22 and and CC cord-010092-uftc8inx 11908 23 transfusion transfusion NN cord-010092-uftc8inx 11908 24 for for IN cord-010092-uftc8inx 11908 25 the the DT cord-010092-uftc8inx 11908 26 correction correction NN cord-010092-uftc8inx 11908 27 of of IN cord-010092-uftc8inx 11908 28 anemia anemia NN cord-010092-uftc8inx 11908 29 . . . cord-010092-uftc8inx 11909 1 Informed informed JJ cord-010092-uftc8inx 11909 2 consent consent NN cord-010092-uftc8inx 11909 3 was be VBD cord-010092-uftc8inx 11909 4 taken take VBN cord-010092-uftc8inx 11909 5 from from IN cord-010092-uftc8inx 11909 6 the the DT cord-010092-uftc8inx 11909 7 participants participant NNS cord-010092-uftc8inx 11909 8 . . . cord-010092-uftc8inx 11910 1 Descriptive descriptive JJ cord-010092-uftc8inx 11910 2 and and CC cord-010092-uftc8inx 11910 3 inferential inferential JJ cord-010092-uftc8inx 11910 4 statistics statistic NNS cord-010092-uftc8inx 11910 5 was be VBD cord-010092-uftc8inx 11910 6 applied apply VBN cord-010092-uftc8inx 11910 7 by by IN cord-010092-uftc8inx 11910 8 using use VBG cord-010092-uftc8inx 11910 9 SPSS SPSS NNP cord-010092-uftc8inx 11910 10 version version NN cord-010092-uftc8inx 11910 11 23.0 23.0 CD cord-010092-uftc8inx 11910 12 . . . cord-010092-uftc8inx 11911 1 Results result NNS cord-010092-uftc8inx 11911 2 : : : cord-010092-uftc8inx 11912 1 A a DT cord-010092-uftc8inx 11912 2 total total NN cord-010092-uftc8inx 11912 3 of of IN cord-010092-uftc8inx 11912 4 108 108 CD cord-010092-uftc8inx 11912 5 IDA IDA NNP cord-010092-uftc8inx 11912 6 patients patient NNS cord-010092-uftc8inx 11912 7 were be VBD cord-010092-uftc8inx 11912 8 analyzed analyze VBN cord-010092-uftc8inx 11912 9 in in IN cord-010092-uftc8inx 11912 10 which which WDT cord-010092-uftc8inx 11912 11 74(69 74(69 CD cord-010092-uftc8inx 11912 12 % % NN cord-010092-uftc8inx 11912 13 ) ) -RRB- cord-010092-uftc8inx 11912 14 were be VBD cord-010092-uftc8inx 11912 15 females female NNS cord-010092-uftc8inx 11912 16 and and CC cord-010092-uftc8inx 11912 17 34(31 34(31 CD cord-010092-uftc8inx 11912 18 % % NN cord-010092-uftc8inx 11912 19 ) ) -RRB- cord-010092-uftc8inx 11912 20 were be VBD cord-010092-uftc8inx 11912 21 males male NNS cord-010092-uftc8inx 11912 22 . . . cord-010092-uftc8inx 11913 1 The the DT cord-010092-uftc8inx 11913 2 most most RBS cord-010092-uftc8inx 11913 3 common common JJ cord-010092-uftc8inx 11913 4 symptom symptom NN cord-010092-uftc8inx 11913 5 in in IN cord-010092-uftc8inx 11913 6 females female NNS cord-010092-uftc8inx 11913 7 and and CC cord-010092-uftc8inx 11913 8 males male NNS cord-010092-uftc8inx 11913 9 was be VBD cord-010092-uftc8inx 11913 10 fatigue fatigue NN cord-010092-uftc8inx 11913 11 followed follow VBN cord-010092-uftc8inx 11913 12 by by IN cord-010092-uftc8inx 11913 13 body body NN cord-010092-uftc8inx 11913 14 aches ache NNS cord-010092-uftc8inx 11913 15 in in IN cord-010092-uftc8inx 11913 16 females female NNS cord-010092-uftc8inx 11913 17 12(16 12(16 CD cord-010092-uftc8inx 11913 18 % % NN cord-010092-uftc8inx 11913 19 ) ) -RRB- cord-010092-uftc8inx 11913 20 and and CC cord-010092-uftc8inx 11913 21 pallor pallor NN cord-010092-uftc8inx 11913 22 in in IN cord-010092-uftc8inx 11913 23 males male NNS cord-010092-uftc8inx 11913 24 10(29 10(29 CD cord-010092-uftc8inx 11913 25 % % NN cord-010092-uftc8inx 11913 26 ) ) -RRB- cord-010092-uftc8inx 11913 27 . . . cord-010092-uftc8inx 11914 1 Menorrhagia Menorrhagia NNP cord-010092-uftc8inx 11914 2 was be VBD cord-010092-uftc8inx 11914 3 present present JJ cord-010092-uftc8inx 11914 4 in in IN cord-010092-uftc8inx 11914 5 24(44 24(44 CD cord-010092-uftc8inx 11914 6 % % NN cord-010092-uftc8inx 11914 7 ) ) -RRB- cord-010092-uftc8inx 11914 8 of of IN cord-010092-uftc8inx 11914 9 females female NNS cord-010092-uftc8inx 11914 10 of of IN cord-010092-uftc8inx 11914 11 reproductive reproductive JJ cord-010092-uftc8inx 11914 12 age age NN cord-010092-uftc8inx 11914 13 . . . cord-010092-uftc8inx 11915 1 Surgical surgical JJ cord-010092-uftc8inx 11915 2 history history NN cord-010092-uftc8inx 11915 3 was be VBD cord-010092-uftc8inx 11915 4 present present JJ cord-010092-uftc8inx 11915 5 in in IN cord-010092-uftc8inx 11915 6 12(16 12(16 CD cord-010092-uftc8inx 11915 7 % % NN cord-010092-uftc8inx 11915 8 ) ) -RRB- cord-010092-uftc8inx 11915 9 of of IN cord-010092-uftc8inx 11915 10 females female NNS cord-010092-uftc8inx 11915 11 while while IN cord-010092-uftc8inx 11915 12 there there EX cord-010092-uftc8inx 11915 13 was be VBD cord-010092-uftc8inx 11915 14 no no DT cord-010092-uftc8inx 11915 15 surgical surgical JJ cord-010092-uftc8inx 11915 16 history history NN cord-010092-uftc8inx 11915 17 in in IN cord-010092-uftc8inx 11915 18 males male NNS cord-010092-uftc8inx 11915 19 . . . cord-010092-uftc8inx 11916 1 Mean mean JJ cord-010092-uftc8inx 11916 2 Hemoglobin Hemoglobin NNP cord-010092-uftc8inx 11916 3 , , , cord-010092-uftc8inx 11916 4 MCH MCH NNP cord-010092-uftc8inx 11916 5 and and CC cord-010092-uftc8inx 11916 6 MCV MCV NNP cord-010092-uftc8inx 11916 7 of of IN cord-010092-uftc8inx 11916 8 females female NNS cord-010092-uftc8inx 11916 9 at at IN cord-010092-uftc8inx 11916 10 baseline baseline NN cord-010092-uftc8inx 11916 11 was be VBD cord-010092-uftc8inx 11916 12 8.0 8.0 CD cord-010092-uftc8inx 11916 13 AE AE NNP cord-010092-uftc8inx 11916 14 2.2 2.2 CD cord-010092-uftc8inx 11916 15 , , , cord-010092-uftc8inx 11916 16 60.5 60.5 CD cord-010092-uftc8inx 11916 17 AE AE NNP cord-010092-uftc8inx 11916 18 9.6 9.6 CD cord-010092-uftc8inx 11916 19 , , , cord-010092-uftc8inx 11916 20 and and CC cord-010092-uftc8inx 11916 21 20 20 CD cord-010092-uftc8inx 11916 22 AE AE NNP cord-010092-uftc8inx 11916 23 8.3 8.3 CD cord-010092-uftc8inx 11916 24 while while IN cord-010092-uftc8inx 11916 25 in in IN cord-010092-uftc8inx 11916 26 males male NNS cord-010092-uftc8inx 11916 27 it -PRON- PRP cord-010092-uftc8inx 11916 28 was be VBD cord-010092-uftc8inx 11916 29 7.8 7.8 CD cord-010092-uftc8inx 11916 30 AE AE NNP cord-010092-uftc8inx 11916 31 2.3 2.3 CD cord-010092-uftc8inx 11916 32 , , , cord-010092-uftc8inx 11916 33 63 63 CD cord-010092-uftc8inx 11916 34 AE AE NNP cord-010092-uftc8inx 11916 35 14.3 14.3 CD cord-010092-uftc8inx 11916 36 and and CC cord-010092-uftc8inx 11916 37 18.4 18.4 CD cord-010092-uftc8inx 11916 38 AE AE NNP cord-010092-uftc8inx 11916 39 6.1 6.1 CD cord-010092-uftc8inx 11916 40 respectively respectively RB cord-010092-uftc8inx 11916 41 . . . cord-010092-uftc8inx 11917 1 Sixty sixty CD cord-010092-uftc8inx 11917 2 two two CD cord-010092-uftc8inx 11917 3 ( ( -LRB- cord-010092-uftc8inx 11917 4 84 84 CD cord-010092-uftc8inx 11917 5 % % NN cord-010092-uftc8inx 11917 6 ) ) -RRB- cord-010092-uftc8inx 11917 7 females female NNS cord-010092-uftc8inx 11917 8 were be VBD cord-010092-uftc8inx 11917 9 advised advise VBN cord-010092-uftc8inx 11917 10 oral oral JJ cord-010092-uftc8inx 11918 1 and and CC cord-010092-uftc8inx 11918 2 I i NN cord-010092-uftc8inx 11918 3 / / SYM cord-010092-uftc8inx 11918 4 V v NN cord-010092-uftc8inx 11918 5 iron iron NN cord-010092-uftc8inx 11918 6 and and CC cord-010092-uftc8inx 11918 7 12 12 CD cord-010092-uftc8inx 11918 8 ( ( -LRB- cord-010092-uftc8inx 11918 9 16 16 CD cord-010092-uftc8inx 11918 10 % % NN cord-010092-uftc8inx 11918 11 ) ) -RRB- cord-010092-uftc8inx 11918 12 received receive VBD cord-010092-uftc8inx 11918 13 transfusion transfusion NN cord-010092-uftc8inx 11918 14 . . . cord-010092-uftc8inx 11919 1 However however RB cord-010092-uftc8inx 11919 2 , , , cord-010092-uftc8inx 11919 3 in in IN cord-010092-uftc8inx 11919 4 males male NNS cord-010092-uftc8inx 11919 5 8(24 8(24 CD cord-010092-uftc8inx 11919 6 % % NN cord-010092-uftc8inx 11919 7 ) ) -RRB- cord-010092-uftc8inx 11919 8 received receive VBD cord-010092-uftc8inx 11919 9 transfusion transfusion NN cord-010092-uftc8inx 11919 10 and and CC cord-010092-uftc8inx 11919 11 26 26 CD cord-010092-uftc8inx 11919 12 ( ( -LRB- cord-010092-uftc8inx 11919 13 76 76 CD cord-010092-uftc8inx 11919 14 % % NN cord-010092-uftc8inx 11919 15 ) ) -RRB- cord-010092-uftc8inx 11919 16 were be VBD cord-010092-uftc8inx 11919 17 advised advise VBN cord-010092-uftc8inx 11919 18 oral oral JJ cord-010092-uftc8inx 11920 1 and and CC cord-010092-uftc8inx 11920 2 I i NN cord-010092-uftc8inx 11920 3 / / SYM cord-010092-uftc8inx 11920 4 V v NN cord-010092-uftc8inx 11920 5 iron iron NN cord-010092-uftc8inx 11920 6 therapy therapy NN cord-010092-uftc8inx 11920 7 . . . cord-010092-uftc8inx 11921 1 It -PRON- PRP cord-010092-uftc8inx 11921 2 was be VBD cord-010092-uftc8inx 11921 3 observed observe VBN cord-010092-uftc8inx 11921 4 that that IN cord-010092-uftc8inx 11921 5 the the DT cord-010092-uftc8inx 11921 6 increment increment NN cord-010092-uftc8inx 11921 7 of of IN cord-010092-uftc8inx 11921 8 hemoglobin hemoglobin NN cord-010092-uftc8inx 11921 9 after after IN cord-010092-uftc8inx 11921 10 oral oral JJ cord-010092-uftc8inx 11921 11 / / SYM cord-010092-uftc8inx 11921 12 IV IV NNP cord-010092-uftc8inx 11921 13 iron iron NN cord-010092-uftc8inx 11921 14 at at IN cord-010092-uftc8inx 11921 15 average average NN cord-010092-uftc8inx 11921 16 of of IN cord-010092-uftc8inx 11921 17 3 3 CD cord-010092-uftc8inx 11921 18 months month NNS cord-010092-uftc8inx 11921 19 follow follow VBP cord-010092-uftc8inx 11921 20 up up RP cord-010092-uftc8inx 11921 21 in in IN cord-010092-uftc8inx 11921 22 males male NNS cord-010092-uftc8inx 11921 23 and and CC cord-010092-uftc8inx 11921 24 females female NNS cord-010092-uftc8inx 11921 25 was be VBD cord-010092-uftc8inx 11921 26 same same JJ cord-010092-uftc8inx 11921 27 as as IN cord-010092-uftc8inx 11921 28 that that IN cord-010092-uftc8inx 11921 29 the the DT cord-010092-uftc8inx 11921 30 transfusion transfusion NN cord-010092-uftc8inx 11921 31 ( ( -LRB- cord-010092-uftc8inx 11921 32 P p NN cord-010092-uftc8inx 11921 33 > > XX cord-010092-uftc8inx 11921 34 0.05 0.05 CD cord-010092-uftc8inx 11921 35 ) ) -RRB- cord-010092-uftc8inx 11921 36 . . . cord-010092-uftc8inx 11922 1 Summary Summary NNP cord-010092-uftc8inx 11922 2 / / SYM cord-010092-uftc8inx 11922 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 11922 4 : : : cord-010092-uftc8inx 11923 1 In in IN cord-010092-uftc8inx 11923 2 our -PRON- PRP$ cord-010092-uftc8inx 11923 3 society society NN cord-010092-uftc8inx 11923 4 where where WRB cord-010092-uftc8inx 11923 5 blood blood NN cord-010092-uftc8inx 11923 6 donations donation NNS cord-010092-uftc8inx 11923 7 are be VBP cord-010092-uftc8inx 11923 8 scarce scarce JJ cord-010092-uftc8inx 11923 9 especially especially RB cord-010092-uftc8inx 11923 10 voluntary voluntary JJ cord-010092-uftc8inx 11923 11 blood blood NN cord-010092-uftc8inx 11923 12 donations donation NNS cord-010092-uftc8inx 11923 13 that that WDT cord-010092-uftc8inx 11923 14 are be VBP cord-010092-uftc8inx 11923 15 considered consider VBN cord-010092-uftc8inx 11923 16 to to TO cord-010092-uftc8inx 11923 17 be be VB cord-010092-uftc8inx 11923 18 the the DT cord-010092-uftc8inx 11923 19 safest safe JJS cord-010092-uftc8inx 11923 20 type type NN cord-010092-uftc8inx 11923 21 of of IN cord-010092-uftc8inx 11923 22 blood blood NN cord-010092-uftc8inx 11923 23 donation donation NN cord-010092-uftc8inx 11923 24 . . . cord-010092-uftc8inx 11924 1 We -PRON- PRP cord-010092-uftc8inx 11924 2 would would MD cord-010092-uftc8inx 11924 3 like like VB cord-010092-uftc8inx 11924 4 to to TO cord-010092-uftc8inx 11924 5 draw draw VB cord-010092-uftc8inx 11924 6 attention attention NN cord-010092-uftc8inx 11924 7 towards towards IN cord-010092-uftc8inx 11924 8 the the DT cord-010092-uftc8inx 11924 9 alternatives alternative NNS cord-010092-uftc8inx 11924 10 to to TO cord-010092-uftc8inx 11924 11 correct correct VB cord-010092-uftc8inx 11924 12 anemia anemia NN cord-010092-uftc8inx 11924 13 such such JJ cord-010092-uftc8inx 11924 14 as as IN cord-010092-uftc8inx 11924 15 oral oral JJ cord-010092-uftc8inx 11925 1 and and CC cord-010092-uftc8inx 11925 2 I I NNP cord-010092-uftc8inx 11925 3 / / SYM cord-010092-uftc8inx 11925 4 V v NN cord-010092-uftc8inx 11925 5 iron iron NN cord-010092-uftc8inx 11925 6 replacement replacement NN cord-010092-uftc8inx 11925 7 therapy therapy NN cord-010092-uftc8inx 11925 8 as as IN cord-010092-uftc8inx 11925 9 our -PRON- PRP$ cord-010092-uftc8inx 11925 10 results result NNS cord-010092-uftc8inx 11925 11 revealed reveal VBD cord-010092-uftc8inx 11925 12 that that IN cord-010092-uftc8inx 11925 13 there there EX cord-010092-uftc8inx 11925 14 was be VBD cord-010092-uftc8inx 11925 15 no no DT cord-010092-uftc8inx 11925 16 difference difference NN cord-010092-uftc8inx 11925 17 in in IN cord-010092-uftc8inx 11925 18 the the DT cord-010092-uftc8inx 11925 19 increment increment NN cord-010092-uftc8inx 11925 20 of of IN cord-010092-uftc8inx 11925 21 hemoglobin hemoglobin NN cord-010092-uftc8inx 11925 22 between between IN cord-010092-uftc8inx 11925 23 the the DT cord-010092-uftc8inx 11925 24 two two CD cord-010092-uftc8inx 11925 25 groups group NNS cord-010092-uftc8inx 11925 26 . . . cord-010092-uftc8inx 11926 1 We -PRON- PRP cord-010092-uftc8inx 11926 2 need need VBP cord-010092-uftc8inx 11926 3 to to TO cord-010092-uftc8inx 11926 4 educate educate VB cord-010092-uftc8inx 11926 5 our -PRON- PRP$ cord-010092-uftc8inx 11926 6 society society NN cord-010092-uftc8inx 11926 7 especially especially RB cord-010092-uftc8inx 11926 8 the the DT cord-010092-uftc8inx 11926 9 older old JJR cord-010092-uftc8inx 11926 10 age age NN cord-010092-uftc8inx 11926 11 adults adult NNS cord-010092-uftc8inx 11926 12 and and CC cord-010092-uftc8inx 11926 13 young young JJ cord-010092-uftc8inx 11926 14 women woman NNS cord-010092-uftc8inx 11926 15 who who WP cord-010092-uftc8inx 11926 16 are be VBP cord-010092-uftc8inx 11926 17 more more RBR cord-010092-uftc8inx 11926 18 vulnerable vulnerable JJ cord-010092-uftc8inx 11926 19 of of IN cord-010092-uftc8inx 11926 20 getting get VBG cord-010092-uftc8inx 11926 21 IDA IDA NNP cord-010092-uftc8inx 11926 22 to to TO cord-010092-uftc8inx 11926 23 opt opt VB cord-010092-uftc8inx 11926 24 oral oral JJ cord-010092-uftc8inx 11927 1 and and CC cord-010092-uftc8inx 11927 2 I i NN cord-010092-uftc8inx 11927 3 / / SYM cord-010092-uftc8inx 11927 4 V v NN cord-010092-uftc8inx 11927 5 iron iron NN cord-010092-uftc8inx 11927 6 therapy therapy NN cord-010092-uftc8inx 11927 7 . . . cord-010092-uftc8inx 11928 1 It -PRON- PRP cord-010092-uftc8inx 11928 2 will will MD cord-010092-uftc8inx 11928 3 be be VB cord-010092-uftc8inx 11928 4 cost cost VBN cord-010092-uftc8inx 11928 5 effective effective JJ cord-010092-uftc8inx 11928 6 , , , cord-010092-uftc8inx 11928 7 convenient convenient JJ cord-010092-uftc8inx 11928 8 and and CC cord-010092-uftc8inx 11928 9 also also RB cord-010092-uftc8inx 11928 10 has have VBZ cord-010092-uftc8inx 11928 11 less less JJR cord-010092-uftc8inx 11928 12 risk risk NN cord-010092-uftc8inx 11928 13 than than IN cord-010092-uftc8inx 11928 14 transfusion transfusion NN cord-010092-uftc8inx 11928 15 . . . cord-010092-uftc8inx 11929 1 Cellular cellular JJ cord-010092-uftc8inx 11929 2 therapies therapy NNS cord-010092-uftc8inx 11929 3 -Stem -stem SYM cord-010092-uftc8inx 11929 4 cell cell NN cord-010092-uftc8inx 11929 5 and and CC cord-010092-uftc8inx 11929 6 tissue tissue NN cord-010092-uftc8inx 11929 7 banking banking NN cord-010092-uftc8inx 11929 8 , , , cord-010092-uftc8inx 11929 9 including include VBG cord-010092-uftc8inx 11929 10 cord cord NN cord-010092-uftc8inx 11929 11 blood blood NN cord-010092-uftc8inx 11929 12 Background background NN cord-010092-uftc8inx 11929 13 : : : cord-010092-uftc8inx 11930 1 The the DT cord-010092-uftc8inx 11930 2 differentiation differentiation NN cord-010092-uftc8inx 11930 3 of of IN cord-010092-uftc8inx 11930 4 megakaryocytes megakaryocytes NNP cord-010092-uftc8inx 11930 5 plays play VBZ cord-010092-uftc8inx 11930 6 an an DT cord-010092-uftc8inx 11930 7 important important JJ cord-010092-uftc8inx 11930 8 role role NN cord-010092-uftc8inx 11930 9 in in IN cord-010092-uftc8inx 11930 10 the the DT cord-010092-uftc8inx 11930 11 production production NN cord-010092-uftc8inx 11930 12 of of IN cord-010092-uftc8inx 11930 13 platelets platelet NNS cord-010092-uftc8inx 11930 14 . . . cord-010092-uftc8inx 11931 1 However however RB cord-010092-uftc8inx 11931 2 , , , cord-010092-uftc8inx 11931 3 the the DT cord-010092-uftc8inx 11931 4 underlying underlie VBG cord-010092-uftc8inx 11931 5 mechanisms mechanism NNS cord-010092-uftc8inx 11931 6 regulating regulate VBG cord-010092-uftc8inx 11931 7 megakaryocytes megakaryocyte NNS cord-010092-uftc8inx 11931 8 differentiation differentiation NN cord-010092-uftc8inx 11931 9 have have VBP cord-010092-uftc8inx 11931 10 rarely rarely RB cord-010092-uftc8inx 11931 11 been be VBN cord-010092-uftc8inx 11931 12 studied study VBN cord-010092-uftc8inx 11931 13 . . . cord-010092-uftc8inx 11932 1 Aims aim VBZ cord-010092-uftc8inx 11932 2 : : : cord-010092-uftc8inx 11933 1 To to TO cord-010092-uftc8inx 11933 2 identify identify VB cord-010092-uftc8inx 11933 3 candidate candidate NN cord-010092-uftc8inx 11933 4 genes gene NNS cord-010092-uftc8inx 11933 5 involved involve VBN cord-010092-uftc8inx 11933 6 in in IN cord-010092-uftc8inx 11933 7 megakaryocytes megakaryocyte NNS cord-010092-uftc8inx 11933 8 differentiation differentiation NN cord-010092-uftc8inx 11933 9 and and CC cord-010092-uftc8inx 11933 10 investigate investigate VB cord-010092-uftc8inx 11933 11 the the DT cord-010092-uftc8inx 11933 12 potential potential JJ cord-010092-uftc8inx 11933 13 regulatory regulatory JJ cord-010092-uftc8inx 11933 14 mechanisms mechanism NNS cord-010092-uftc8inx 11933 15 of of IN cord-010092-uftc8inx 11933 16 megakaryocytes megakaryocyte NNS cord-010092-uftc8inx 11933 17 differentiation differentiation NN cord-010092-uftc8inx 11933 18 from from IN cord-010092-uftc8inx 11933 19 human human JJ cord-010092-uftc8inx 11933 20 cord cord NN cord-010092-uftc8inx 11933 21 blood blood NN cord-010092-uftc8inx 11933 22 hematopoietic hematopoietic JJ cord-010092-uftc8inx 11933 23 stem stem NN cord-010092-uftc8inx 11933 24 cells cell NNS cord-010092-uftc8inx 11933 25 in in IN cord-010092-uftc8inx 11933 26 vitro vitro FW cord-010092-uftc8inx 11933 27 . . . cord-010092-uftc8inx 11934 1 Methods method NNS cord-010092-uftc8inx 11934 2 : : : cord-010092-uftc8inx 11935 1 CB CB NNP cord-010092-uftc8inx 11935 2 - - HYPH cord-010092-uftc8inx 11935 3 derived derive VBN cord-010092-uftc8inx 11935 4 CD34 CD34 NNP cord-010092-uftc8inx 11935 5 + + CC cord-010092-uftc8inx 11935 6 cells cell NNS cord-010092-uftc8inx 11935 7 were be VBD cord-010092-uftc8inx 11935 8 isolated isolate VBN cord-010092-uftc8inx 11935 9 using use VBG cord-010092-uftc8inx 11935 10 density density NN cord-010092-uftc8inx 11935 11 gradient gradient NN cord-010092-uftc8inx 11935 12 centrifugation centrifugation NN cord-010092-uftc8inx 11935 13 and and CC cord-010092-uftc8inx 11935 14 magnetic magnetic JJ cord-010092-uftc8inx 11935 15 activated activate VBN cord-010092-uftc8inx 11935 16 cell cell NN cord-010092-uftc8inx 11935 17 sorting sorting NN cord-010092-uftc8inx 11935 18 ( ( -LRB- cord-010092-uftc8inx 11935 19 MACS MACS NNP cord-010092-uftc8inx 11935 20 ) ) -RRB- cord-010092-uftc8inx 11935 21 . . . cord-010092-uftc8inx 11936 1 Cultures culture NNS cord-010092-uftc8inx 11936 2 were be VBD cord-010092-uftc8inx 11936 3 stimulated stimulate VBN cord-010092-uftc8inx 11936 4 with with IN cord-010092-uftc8inx 11936 5 only only RB cord-010092-uftc8inx 11936 6 recombinant recombinant JJ cord-010092-uftc8inx 11936 7 human human NN cord-010092-uftc8inx 11936 8 TPO TPO NNP cord-010092-uftc8inx 11936 9 ( ( -LRB- cord-010092-uftc8inx 11936 10 100 100 CD cord-010092-uftc8inx 11936 11 ng ng NN cord-010092-uftc8inx 11936 12 / / SYM cord-010092-uftc8inx 11936 13 ml ml NN cord-010092-uftc8inx 11936 14 ) ) -RRB- cord-010092-uftc8inx 11936 15 . . . cord-010092-uftc8inx 11937 1 After after IN cord-010092-uftc8inx 11937 2 12 12 CD cord-010092-uftc8inx 11937 3 , , , cord-010092-uftc8inx 11937 4 14 14 CD cord-010092-uftc8inx 11937 5 and and CC cord-010092-uftc8inx 11937 6 18 18 CD cord-010092-uftc8inx 11937 7 days day NNS cord-010092-uftc8inx 11937 8 , , , cord-010092-uftc8inx 11937 9 the the DT cord-010092-uftc8inx 11937 10 MK MK NNP cord-010092-uftc8inx 11937 11 fraction fraction NN cord-010092-uftc8inx 11937 12 was be VBD cord-010092-uftc8inx 11937 13 selected select VBN cord-010092-uftc8inx 11937 14 by by IN cord-010092-uftc8inx 11937 15 immunomagnetic immunomagnetic JJ cord-010092-uftc8inx 11937 16 sorting sorting NN cord-010092-uftc8inx 11937 17 from from IN cord-010092-uftc8inx 11937 18 the the DT cord-010092-uftc8inx 11937 19 non non JJ cord-010092-uftc8inx 11937 20 - - JJ cord-010092-uftc8inx 11937 21 MK mk JJ cord-010092-uftc8inx 11937 22 fraction fraction NN cord-010092-uftc8inx 11937 23 using use VBG cord-010092-uftc8inx 11937 24 an an DT cord-010092-uftc8inx 11937 25 anti anti JJ cord-010092-uftc8inx 11937 26 - - JJ cord-010092-uftc8inx 11937 27 CD41a cd41a JJ cord-010092-uftc8inx 11937 28 monoclonal monoclonal JJ cord-010092-uftc8inx 11937 29 antibody antibody NN cord-010092-uftc8inx 11937 30 . . . cord-010092-uftc8inx 11938 1 RNA RNA NNP cord-010092-uftc8inx 11938 2 - - HYPH cord-010092-uftc8inx 11938 3 Seq seq NN cord-010092-uftc8inx 11938 4 - - HYPH cord-010092-uftc8inx 11938 5 derived derive VBN cord-010092-uftc8inx 11938 6 gene gene NN cord-010092-uftc8inx 11938 7 expression expression NN cord-010092-uftc8inx 11938 8 data datum NNS cord-010092-uftc8inx 11938 9 was be VBD cord-010092-uftc8inx 11938 10 performed perform VBN cord-010092-uftc8inx 11938 11 on on IN cord-010092-uftc8inx 11938 12 uncultured uncultured JJ cord-010092-uftc8inx 11938 13 samples sample NNS cord-010092-uftc8inx 11938 14 ( ( -LRB- cord-010092-uftc8inx 11938 15 day day NN cord-010092-uftc8inx 11938 16 0 0 CD cord-010092-uftc8inx 11938 17 ) ) -RRB- cord-010092-uftc8inx 11938 18 , , , cord-010092-uftc8inx 11938 19 cultured cultured JJ cord-010092-uftc8inx 11938 20 but but CC cord-010092-uftc8inx 11938 21 unselected unselected JJ cord-010092-uftc8inx 11938 22 samples sample NNS cord-010092-uftc8inx 11938 23 ( ( -LRB- cord-010092-uftc8inx 11938 24 day day NN cord-010092-uftc8inx 11938 25 7 7 CD cord-010092-uftc8inx 11938 26 ) ) -RRB- cord-010092-uftc8inx 11938 27 , , , cord-010092-uftc8inx 11938 28 and and CC cord-010092-uftc8inx 11938 29 cultured cultured JJ cord-010092-uftc8inx 11938 30 , , , cord-010092-uftc8inx 11938 31 selected select VBN cord-010092-uftc8inx 11938 32 samples sample NNS cord-010092-uftc8inx 11938 33 ( ( -LRB- cord-010092-uftc8inx 11938 34 day day NN cord-010092-uftc8inx 11938 35 12 12 CD cord-010092-uftc8inx 11938 36 , , , cord-010092-uftc8inx 11938 37 14 14 CD cord-010092-uftc8inx 11938 38 and and CC cord-010092-uftc8inx 11938 39 18 18 CD cord-010092-uftc8inx 11938 40 ) ) -RRB- cord-010092-uftc8inx 11938 41 by by IN cord-010092-uftc8inx 11938 42 using use VBG cord-010092-uftc8inx 11938 43 the the DT cord-010092-uftc8inx 11938 44 next next JJ cord-010092-uftc8inx 11938 45 - - HYPH cord-010092-uftc8inx 11938 46 generation generation NN cord-010092-uftc8inx 11938 47 sequencing sequencing NN cord-010092-uftc8inx 11938 48 ( ( -LRB- cord-010092-uftc8inx 11938 49 NGS NGS NNP cord-010092-uftc8inx 11938 50 ) ) -RRB- cord-010092-uftc8inx 11938 51 platform platform NN cord-010092-uftc8inx 11938 52 , , , cord-010092-uftc8inx 11938 53 and and CC cord-010092-uftc8inx 11938 54 RQ rq NN cord-010092-uftc8inx 11938 55 - - HYPH cord-010092-uftc8inx 11938 56 PCR pcr NN cord-010092-uftc8inx 11938 57 technology technology NN cord-010092-uftc8inx 11938 58 was be VBD cord-010092-uftc8inx 11938 59 used use VBN cord-010092-uftc8inx 11938 60 to to TO cord-010092-uftc8inx 11938 61 verify verify VB cord-010092-uftc8inx 11938 62 the the DT cord-010092-uftc8inx 11938 63 expression expression NN cord-010092-uftc8inx 11938 64 of of IN cord-010092-uftc8inx 11938 65 transcription transcription NN cord-010092-uftc8inx 11938 66 factors factor NNS cord-010092-uftc8inx 11938 67 . . . cord-010092-uftc8inx 11939 1 Results result NNS cord-010092-uftc8inx 11939 2 : : : cord-010092-uftc8inx 11940 1 The the DT cord-010092-uftc8inx 11940 2 comparison comparison NN cord-010092-uftc8inx 11940 3 of of IN cord-010092-uftc8inx 11940 4 the the DT cord-010092-uftc8inx 11940 5 transcriptome transcriptome NN cord-010092-uftc8inx 11940 6 profiles profile NNS cord-010092-uftc8inx 11940 7 among among IN cord-010092-uftc8inx 11940 8 the the DT cord-010092-uftc8inx 11940 9 five five CD cord-010092-uftc8inx 11940 10 stages stage NNS cord-010092-uftc8inx 11940 11 showed show VBD cord-010092-uftc8inx 11940 12 that that IN cord-010092-uftc8inx 11940 13 a a DT cord-010092-uftc8inx 11940 14 massive massive JJ cord-010092-uftc8inx 11940 15 gene gene NN cord-010092-uftc8inx 11940 16 expression expression NN cord-010092-uftc8inx 11940 17 change change NN cord-010092-uftc8inx 11940 18 occurred occur VBD cord-010092-uftc8inx 11940 19 in in IN cord-010092-uftc8inx 11940 20 megakaryocytes megakaryocytes NN cord-010092-uftc8inx 11940 21 differentiation differentiation NN cord-010092-uftc8inx 11940 22 . . . cord-010092-uftc8inx 11941 1 A a DT cord-010092-uftc8inx 11941 2 total total NN cord-010092-uftc8inx 11941 3 of of IN cord-010092-uftc8inx 11941 4 65140 65140 CD cord-010092-uftc8inx 11941 5 genes gene NNS cord-010092-uftc8inx 11941 6 were be VBD cord-010092-uftc8inx 11941 7 detected detect VBN cord-010092-uftc8inx 11941 8 , , , cord-010092-uftc8inx 11941 9 of of IN cord-010092-uftc8inx 11941 10 which which WDT cord-010092-uftc8inx 11941 11 16612 16612 CD cord-010092-uftc8inx 11941 12 showed show VBD cord-010092-uftc8inx 11941 13 up up IN cord-010092-uftc8inx 11941 14 - - HYPH cord-010092-uftc8inx 11941 15 regulation regulation NN cord-010092-uftc8inx 11941 16 and and CC cord-010092-uftc8inx 11941 17 48528 48528 CD cord-010092-uftc8inx 11941 18 down down IN cord-010092-uftc8inx 11941 19 - - HYPH cord-010092-uftc8inx 11941 20 regulation regulation NN cord-010092-uftc8inx 11941 21 . . . cord-010092-uftc8inx 11942 1 Among among IN cord-010092-uftc8inx 11942 2 these these DT cord-010092-uftc8inx 11942 3 genes gene NNS cord-010092-uftc8inx 11942 4 , , , cord-010092-uftc8inx 11942 5 8 8 CD cord-010092-uftc8inx 11942 6 differentially differentially RB cord-010092-uftc8inx 11942 7 expressed express VBN cord-010092-uftc8inx 11942 8 genes gene NNS cord-010092-uftc8inx 11942 9 ( ( -LRB- cord-010092-uftc8inx 11942 10 DEGs deg NNS cord-010092-uftc8inx 11942 11 ) ) -RRB- cord-010092-uftc8inx 11942 12 ( ( -LRB- cord-010092-uftc8inx 11942 13 fold fold VB cord-010092-uftc8inx 11942 14 change change NN cord-010092-uftc8inx 11942 15 ≥ ≥ CD cord-010092-uftc8inx 11942 16 10 10 CD cord-010092-uftc8inx 11942 17 ; ; , cord-010092-uftc8inx 11942 18 false false JJ cord-010092-uftc8inx 11942 19 discovery discovery NN cord-010092-uftc8inx 11942 20 rate rate NN cord-010092-uftc8inx 11942 21 < < XX cord-010092-uftc8inx 11942 22 0.05 0.05 CD cord-010092-uftc8inx 11942 23 ) ) -RRB- cord-010092-uftc8inx 11942 24 were be VBD cord-010092-uftc8inx 11942 25 selected select VBN cord-010092-uftc8inx 11942 26 were be VBD cord-010092-uftc8inx 11942 27 further further RB cord-010092-uftc8inx 11942 28 validated validate VBN cord-010092-uftc8inx 11942 29 with with IN cord-010092-uftc8inx 11942 30 RQ RQ NNP cord-010092-uftc8inx 11942 31 - - HYPH cord-010092-uftc8inx 11942 32 PCR PCR NNP cord-010092-uftc8inx 11942 33 , , , cord-010092-uftc8inx 11942 34 including include VBG cord-010092-uftc8inx 11942 35 GABRE GABRE NNP cord-010092-uftc8inx 11942 36 , , , cord-010092-uftc8inx 11942 37 CDHR1 CDHR1 NNP cord-010092-uftc8inx 11942 38 , , , cord-010092-uftc8inx 11942 39 WASF3 WASF3 NNP cord-010092-uftc8inx 11942 40 , , , cord-010092-uftc8inx 11942 41 PKHD1L1 pkhd1l1 CD cord-010092-uftc8inx 11942 42 , , , cord-010092-uftc8inx 11942 43 THBS1 thbs1 NN cord-010092-uftc8inx 11942 44 , , , cord-010092-uftc8inx 11942 45 PF4V1 PF4V1 NNP cord-010092-uftc8inx 11942 46 , , , cord-010092-uftc8inx 11942 47 LRRC32 LRRC32 NNP cord-010092-uftc8inx 11942 48 and and CC cord-010092-uftc8inx 11942 49 LGALS12 LGALS12 NNP cord-010092-uftc8inx 11942 50 . . . cord-010092-uftc8inx 11943 1 The the DT cord-010092-uftc8inx 11943 2 RQ RQ NNP cord-010092-uftc8inx 11943 3 - - HYPH cord-010092-uftc8inx 11943 4 PCR PCR NNP cord-010092-uftc8inx 11943 5 result result NN cord-010092-uftc8inx 11943 6 indicated indicate VBD cord-010092-uftc8inx 11943 7 that that IN cord-010092-uftc8inx 11943 8 the the DT cord-010092-uftc8inx 11943 9 mRNA mRNA NNP cord-010092-uftc8inx 11943 10 expression expression NN cord-010092-uftc8inx 11943 11 level level NN cord-010092-uftc8inx 11943 12 increased increase VBD cord-010092-uftc8inx 11943 13 with with IN cord-010092-uftc8inx 11943 14 the the DT cord-010092-uftc8inx 11943 15 prolongation prolongation NN cord-010092-uftc8inx 11943 16 of of IN cord-010092-uftc8inx 11943 17 culture culture NN cord-010092-uftc8inx 11943 18 time time NN cord-010092-uftc8inx 11943 19 . . . cord-010092-uftc8inx 11944 1 However however RB cord-010092-uftc8inx 11944 2 , , , cord-010092-uftc8inx 11944 3 PF4V1 PF4V1 NNP cord-010092-uftc8inx 11944 4 mRNA mrna NN cord-010092-uftc8inx 11944 5 expression expression NN cord-010092-uftc8inx 11944 6 level level NN cord-010092-uftc8inx 11944 7 was be VBD cord-010092-uftc8inx 11944 8 highest high JJS cord-010092-uftc8inx 11944 9 at at IN cord-010092-uftc8inx 11944 10 day day NN cord-010092-uftc8inx 11944 11 14 14 CD cord-010092-uftc8inx 11944 12 , , , cord-010092-uftc8inx 11944 13 LGALS12 LGALS12 NNP cord-010092-uftc8inx 11944 14 was be VBD cord-010092-uftc8inx 11944 15 highest high JJS cord-010092-uftc8inx 11944 16 at at IN cord-010092-uftc8inx 11944 17 day day NN cord-010092-uftc8inx 11944 18 18 18 CD cord-010092-uftc8inx 11944 19 . . . cord-010092-uftc8inx 11945 1 Summary Summary NNP cord-010092-uftc8inx 11945 2 / / SYM cord-010092-uftc8inx 11945 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 11945 4 : : : cord-010092-uftc8inx 11946 1 Conclusion conclusion NN cord-010092-uftc8inx 11946 2 : : : cord-010092-uftc8inx 11947 1 Our -PRON- PRP$ cord-010092-uftc8inx 11947 2 study study NN cord-010092-uftc8inx 11947 3 identified identify VBD cord-010092-uftc8inx 11947 4 a a DT cord-010092-uftc8inx 11947 5 series series NN cord-010092-uftc8inx 11947 6 of of IN cord-010092-uftc8inx 11947 7 genes gene NNS cord-010092-uftc8inx 11947 8 that that WDT cord-010092-uftc8inx 11947 9 may may MD cord-010092-uftc8inx 11947 10 participate participate VB cord-010092-uftc8inx 11947 11 in in IN cord-010092-uftc8inx 11947 12 the the DT cord-010092-uftc8inx 11947 13 regulation regulation NN cord-010092-uftc8inx 11947 14 of of IN cord-010092-uftc8inx 11947 15 megakaryocytes megakaryocyte NNS cord-010092-uftc8inx 11947 16 differentiation differentiation NN cord-010092-uftc8inx 11947 17 . . . cord-010092-uftc8inx 11948 1 These these DT cord-010092-uftc8inx 11948 2 results result NNS cord-010092-uftc8inx 11948 3 should should MD cord-010092-uftc8inx 11948 4 serve serve VB cord-010092-uftc8inx 11948 5 as as IN cord-010092-uftc8inx 11948 6 an an DT cord-010092-uftc8inx 11948 7 important important JJ cord-010092-uftc8inx 11948 8 resource resource NN cord-010092-uftc8inx 11948 9 revealing reveal VBG cord-010092-uftc8inx 11948 10 the the DT cord-010092-uftc8inx 11948 11 molecular molecular JJ cord-010092-uftc8inx 11948 12 basis basis NN cord-010092-uftc8inx 11948 13 of of IN cord-010092-uftc8inx 11948 14 megakaryocytes megakaryocytes NNP cord-010092-uftc8inx 11948 15 differentiation differentiation NN cord-010092-uftc8inx 11948 16 and and CC cord-010092-uftc8inx 11948 17 thrombocytopoiesis thrombocytopoiesis NN cord-010092-uftc8inx 11948 18 . . . cord-010092-uftc8inx 11949 1 PREOPERATIVE PREOPERATIVE NNP cord-010092-uftc8inx 11949 2 ANEMIA anemia NN cord-010092-uftc8inx 11949 3 AND and CC cord-010092-uftc8inx 11949 4 BLOOD blood NN cord-010092-uftc8inx 11949 5 TRANSFUSION transfusion NN cord-010092-uftc8inx 11949 6 REQUIREMENT requirement NN cord-010092-uftc8inx 11949 7 DURING during IN cord-010092-uftc8inx 11949 8 HIP hip NN cord-010092-uftc8inx 11949 9 AND and CC cord-010092-uftc8inx 11949 10 KNEE knee NN cord-010092-uftc8inx 11949 11 SURGERY surgery NN cord-010092-uftc8inx 11949 12 Rambam Rambam NNP cord-010092-uftc8inx 11949 13 Health Health NNP cord-010092-uftc8inx 11949 14 Care Care NNP cord-010092-uftc8inx 11949 15 Campus Campus NNP cord-010092-uftc8inx 11949 16 , , , cord-010092-uftc8inx 11949 17 Haifa Haifa NNP cord-010092-uftc8inx 11949 18 , , , cord-010092-uftc8inx 11950 1 Israel Israel NNP cord-010092-uftc8inx 11950 2 Background Background NNP cord-010092-uftc8inx 11950 3 : : : cord-010092-uftc8inx 11950 4 Blood blood NN cord-010092-uftc8inx 11950 5 transfusion transfusion NN cord-010092-uftc8inx 11950 6 ( ( -LRB- cord-010092-uftc8inx 11950 7 BT BT NNP cord-010092-uftc8inx 11950 8 ) ) -RRB- cord-010092-uftc8inx 11950 9 is be VBZ cord-010092-uftc8inx 11950 10 independently independently RB cord-010092-uftc8inx 11950 11 associated associate VBN cord-010092-uftc8inx 11950 12 with with IN cord-010092-uftc8inx 11950 13 increased increase VBN cord-010092-uftc8inx 11950 14 morbidity morbidity NN cord-010092-uftc8inx 11950 15 , , , cord-010092-uftc8inx 11950 16 mortality mortality NN cord-010092-uftc8inx 11950 17 and and CC cord-010092-uftc8inx 11950 18 hospitalization hospitalization NN cord-010092-uftc8inx 11950 19 length length NN cord-010092-uftc8inx 11950 20 across across IN cord-010092-uftc8inx 11950 21 different different JJ cord-010092-uftc8inx 11950 22 patient patient JJ cord-010092-uftc8inx 11950 23 populations population NNS cord-010092-uftc8inx 11950 24 . . . cord-010092-uftc8inx 11951 1 Due due IN cord-010092-uftc8inx 11951 2 to to IN cord-010092-uftc8inx 11951 3 BT BT NNP cord-010092-uftc8inx 11951 4 - - HYPH cord-010092-uftc8inx 11951 5 related relate VBN cord-010092-uftc8inx 11951 6 risks risk NNS cord-010092-uftc8inx 11951 7 , , , cord-010092-uftc8inx 11951 8 the the DT cord-010092-uftc8inx 11951 9 concept concept NN cord-010092-uftc8inx 11951 10 of of IN cord-010092-uftc8inx 11951 11 " " `` cord-010092-uftc8inx 11951 12 Patient Patient NNP cord-010092-uftc8inx 11951 13 Blood Blood NNP cord-010092-uftc8inx 11951 14 Management Management NNP cord-010092-uftc8inx 11951 15 " " '' cord-010092-uftc8inx 11951 16 ( ( -LRB- cord-010092-uftc8inx 11951 17 PBM PBM NNP cord-010092-uftc8inx 11951 18 ) ) -RRB- cord-010092-uftc8inx 11951 19 has have VBZ cord-010092-uftc8inx 11951 20 been be VBN cord-010092-uftc8inx 11951 21 introduced introduce VBN cord-010092-uftc8inx 11951 22 to to IN cord-010092-uftc8inx 11951 23 clinical clinical JJ cord-010092-uftc8inx 11951 24 practice practice NN cord-010092-uftc8inx 11951 25 . . . cord-010092-uftc8inx 11952 1 The the DT cord-010092-uftc8inx 11952 2 three three CD cord-010092-uftc8inx 11952 3 PBM PBM NNP cord-010092-uftc8inx 11952 4 pillars pillar NNS cord-010092-uftc8inx 11952 5 are be VBP cord-010092-uftc8inx 11952 6 : : : cord-010092-uftc8inx 11952 7 optimizing optimize VBG cord-010092-uftc8inx 11952 8 red red JJ cord-010092-uftc8inx 11952 9 cell cell NN cord-010092-uftc8inx 11952 10 mass mass NN cord-010092-uftc8inx 11952 11 , , , cord-010092-uftc8inx 11952 12 minimizing minimize VBG cord-010092-uftc8inx 11952 13 blood blood NN cord-010092-uftc8inx 11952 14 loss loss NN cord-010092-uftc8inx 11952 15 and and CC cord-010092-uftc8inx 11952 16 optimizing optimize VBG cord-010092-uftc8inx 11952 17 physiological physiological JJ cord-010092-uftc8inx 11952 18 reserve reserve NN cord-010092-uftc8inx 11952 19 . . . cord-010092-uftc8inx 11953 1 BT BT NNP cord-010092-uftc8inx 11953 2 indications indication NNS cord-010092-uftc8inx 11953 3 during during IN cord-010092-uftc8inx 11953 4 orthopedic orthopedic NN cord-010092-uftc8inx 11953 5 surgery surgery NN cord-010092-uftc8inx 11953 6 include include VBP cord-010092-uftc8inx 11953 7 excessive excessive JJ cord-010092-uftc8inx 11953 8 bleeding bleeding NN cord-010092-uftc8inx 11953 9 or or CC cord-010092-uftc8inx 11953 10 hemodynamic hemodynamic JJ cord-010092-uftc8inx 11953 11 instability instability NN cord-010092-uftc8inx 11953 12 and and CC cord-010092-uftc8inx 11953 13 not not RB cord-010092-uftc8inx 11953 14 the the DT cord-010092-uftc8inx 11953 15 hemoglobin hemoglobin NN cord-010092-uftc8inx 11953 16 ( ( -LRB- cord-010092-uftc8inx 11953 17 Hb Hb NNP cord-010092-uftc8inx 11953 18 ) ) -RRB- cord-010092-uftc8inx 11953 19 level level NN cord-010092-uftc8inx 11953 20 . . . cord-010092-uftc8inx 11954 1 In in IN cord-010092-uftc8inx 11954 2 most most JJS cord-010092-uftc8inx 11954 3 clinical clinical JJ cord-010092-uftc8inx 11954 4 scenarios scenario NNS cord-010092-uftc8inx 11954 5 , , , cord-010092-uftc8inx 11954 6 a a DT cord-010092-uftc8inx 11954 7 restrictive restrictive JJ cord-010092-uftc8inx 11954 8 transfusion transfusion NN cord-010092-uftc8inx 11954 9 threshold threshold NN cord-010092-uftc8inx 11954 10 ( ( -LRB- cord-010092-uftc8inx 11954 11 Hb Hb NNP cord-010092-uftc8inx 11954 12 level level NN cord-010092-uftc8inx 11954 13 : : : cord-010092-uftc8inx 11954 14 7 7 CD cord-010092-uftc8inx 11954 15 - - SYM cord-010092-uftc8inx 11954 16 8 8 CD cord-010092-uftc8inx 11954 17 g g NN cord-010092-uftc8inx 11954 18 / / SYM cord-010092-uftc8inx 11954 19 dL dl NN cord-010092-uftc8inx 11954 20 ) ) -RRB- cord-010092-uftc8inx 11954 21 appears appear VBZ cord-010092-uftc8inx 11954 22 to to TO cord-010092-uftc8inx 11954 23 be be VB cord-010092-uftc8inx 11954 24 non non JJ cord-010092-uftc8inx 11954 25 - - JJ cord-010092-uftc8inx 11954 26 inferior inferior JJ cord-010092-uftc8inx 11954 27 to to IN cord-010092-uftc8inx 11954 28 the the DT cord-010092-uftc8inx 11954 29 liberal liberal JJ cord-010092-uftc8inx 11954 30 transfusion transfusion NN cord-010092-uftc8inx 11954 31 strategy strategy NN cord-010092-uftc8inx 11954 32 in in IN cord-010092-uftc8inx 11954 33 terms term NNS cord-010092-uftc8inx 11954 34 of of IN cord-010092-uftc8inx 11954 35 blood blood NN cord-010092-uftc8inx 11954 36 use use NN cord-010092-uftc8inx 11954 37 , , , cord-010092-uftc8inx 11954 38 morbidity morbidity NN cord-010092-uftc8inx 11954 39 and and CC cord-010092-uftc8inx 11954 40 mortality mortality NN cord-010092-uftc8inx 11954 41 . . . cord-010092-uftc8inx 11955 1 Similar similar JJ cord-010092-uftc8inx 11955 2 results result NNS cord-010092-uftc8inx 11955 3 are be VBP cord-010092-uftc8inx 11955 4 observed observe VBN cord-010092-uftc8inx 11955 5 in in IN cord-010092-uftc8inx 11955 6 highrisk highrisk JJ cord-010092-uftc8inx 11955 7 patients patient NNS cord-010092-uftc8inx 11955 8 after after IN cord-010092-uftc8inx 11955 9 hip hip NN cord-010092-uftc8inx 11955 10 surgery surgery NN cord-010092-uftc8inx 11955 11 . . . cord-010092-uftc8inx 11956 1 We -PRON- PRP cord-010092-uftc8inx 11956 2 hypothesize hypothesize VBP cord-010092-uftc8inx 11956 3 that that IN cord-010092-uftc8inx 11956 4 preoperative preoperative JJ cord-010092-uftc8inx 11956 5 anemia anemia NN cord-010092-uftc8inx 11956 6 may may MD cord-010092-uftc8inx 11956 7 lead lead VB cord-010092-uftc8inx 11956 8 to to IN cord-010092-uftc8inx 11956 9 blood blood NN cord-010092-uftc8inx 11956 10 product product NN cord-010092-uftc8inx 11956 11 overuse overuse NN cord-010092-uftc8inx 11956 12 and and CC cord-010092-uftc8inx 11956 13 its -PRON- PRP$ cord-010092-uftc8inx 11956 14 complications complication NNS cord-010092-uftc8inx 11956 15 . . . cord-010092-uftc8inx 11957 1 Aims aim VBZ cord-010092-uftc8inx 11957 2 : : : cord-010092-uftc8inx 11957 3 Evaluating evaluate VBG cord-010092-uftc8inx 11957 4 potential potential JJ cord-010092-uftc8inx 11957 5 correlation correlation NN cord-010092-uftc8inx 11957 6 between between IN cord-010092-uftc8inx 11957 7 preoperative preoperative JJ cord-010092-uftc8inx 11957 8 anemia anemia NN cord-010092-uftc8inx 11957 9 and and CC cord-010092-uftc8inx 11957 10 BT BT NNP cord-010092-uftc8inx 11957 11 requirement requirement NN cord-010092-uftc8inx 11957 12 during during IN cord-010092-uftc8inx 11957 13 hip hip NN cord-010092-uftc8inx 11957 14 or or CC cord-010092-uftc8inx 11957 15 knee knee NN cord-010092-uftc8inx 11957 16 surgery surgery NN cord-010092-uftc8inx 11957 17 . . . cord-010092-uftc8inx 11958 1 Methods method NNS cord-010092-uftc8inx 11958 2 : : : cord-010092-uftc8inx 11958 3 We -PRON- PRP cord-010092-uftc8inx 11958 4 reviewed review VBD cord-010092-uftc8inx 11958 5 medical medical JJ cord-010092-uftc8inx 11958 6 files file NNS cord-010092-uftc8inx 11958 7 of of IN cord-010092-uftc8inx 11958 8 patients patient NNS cord-010092-uftc8inx 11958 9 who who WP cord-010092-uftc8inx 11958 10 underwent undergo VBD cord-010092-uftc8inx 11958 11 hip hip NN cord-010092-uftc8inx 11958 12 or or CC cord-010092-uftc8inx 11958 13 knee knee NN cord-010092-uftc8inx 11958 14 replacement replacement NN cord-010092-uftc8inx 11958 15 surgery surgery NN cord-010092-uftc8inx 11958 16 at at IN cord-010092-uftc8inx 11958 17 Rambam Rambam NNP cord-010092-uftc8inx 11958 18 between between IN cord-010092-uftc8inx 11958 19 2011 2011 CD cord-010092-uftc8inx 11958 20 - - SYM cord-010092-uftc8inx 11958 21 2018 2018 CD cord-010092-uftc8inx 11958 22 . . . cord-010092-uftc8inx 11959 1 Patients patient NNS cord-010092-uftc8inx 11959 2 with with IN cord-010092-uftc8inx 11959 3 Hb Hb NNP cord-010092-uftc8inx 11959 4 level level NN cord-010092-uftc8inx 11959 5 measurement measurement NN cord-010092-uftc8inx 11959 6 within within IN cord-010092-uftc8inx 11959 7 90 90 CD cord-010092-uftc8inx 11959 8 days day NNS cord-010092-uftc8inx 11959 9 pre pre JJ cord-010092-uftc8inx 11959 10 - - NN cord-010092-uftc8inx 11959 11 surgery surgery NN cord-010092-uftc8inx 11959 12 were be VBD cord-010092-uftc8inx 11959 13 included include VBN cord-010092-uftc8inx 11959 14 . . . cord-010092-uftc8inx 11960 1 Receiving receive VBG cord-010092-uftc8inx 11960 2 > > XX cord-010092-uftc8inx 11960 3 1 1 CD cord-010092-uftc8inx 11960 4 blood blood NN cord-010092-uftc8inx 11960 5 unit unit NN cord-010092-uftc8inx 11960 6 was be VBD cord-010092-uftc8inx 11960 7 considered consider VBN cord-010092-uftc8inx 11960 8 a a DT cord-010092-uftc8inx 11960 9 surgery surgery NN cord-010092-uftc8inx 11960 10 complication complication NN cord-010092-uftc8inx 11960 11 and and CC cord-010092-uftc8inx 11960 12 such such JJ cord-010092-uftc8inx 11960 13 patients patient NNS cord-010092-uftc8inx 11960 14 were be VBD cord-010092-uftc8inx 11960 15 excluded exclude VBN cord-010092-uftc8inx 11960 16 . . . cord-010092-uftc8inx 11961 1 Patient patient JJ cord-010092-uftc8inx 11961 2 demographic demographic JJ cord-010092-uftc8inx 11961 3 and and CC cord-010092-uftc8inx 11961 4 clinical clinical JJ cord-010092-uftc8inx 11961 5 data datum NNS cord-010092-uftc8inx 11961 6 , , , cord-010092-uftc8inx 11961 7 including include VBG cord-010092-uftc8inx 11961 8 comorbidities comorbiditie NNS cord-010092-uftc8inx 11961 9 , , , cord-010092-uftc8inx 11961 10 surgery surgery NN cord-010092-uftc8inx 11961 11 type type NN cord-010092-uftc8inx 11961 12 , , , cord-010092-uftc8inx 11961 13 length length NN cord-010092-uftc8inx 11961 14 of of IN cord-010092-uftc8inx 11961 15 hospital hospital NN cord-010092-uftc8inx 11961 16 stay stay NN cord-010092-uftc8inx 11961 17 , , , cord-010092-uftc8inx 11961 18 were be VBD cord-010092-uftc8inx 11961 19 collected collect VBN cord-010092-uftc8inx 11961 20 . . . cord-010092-uftc8inx 11962 1 We -PRON- PRP cord-010092-uftc8inx 11962 2 created create VBD cord-010092-uftc8inx 11962 3 a a DT cord-010092-uftc8inx 11962 4 synthetic synthetic JJ cord-010092-uftc8inx 11962 5 data data NN cord-010092-uftc8inx 11962 6 cohort cohort NN cord-010092-uftc8inx 11962 7 using use VBG cord-010092-uftc8inx 11962 8 MDClone MDClone NNP cord-010092-uftc8inx 11962 9 Healthcare Healthcare NNP cord-010092-uftc8inx 11962 10 Data Data NNP cord-010092-uftc8inx 11962 11 Sandbox Sandbox NNP cord-010092-uftc8inx 11962 12 , , , cord-010092-uftc8inx 11962 13 an an DT cord-010092-uftc8inx 11962 14 environment environment NN cord-010092-uftc8inx 11962 15 enabling enable VBG cord-010092-uftc8inx 11962 16 fast fast JJ cord-010092-uftc8inx 11962 17 data data NN cord-010092-uftc8inx 11962 18 extraction extraction NN cord-010092-uftc8inx 11962 19 and and CC cord-010092-uftc8inx 11962 20 producing produce VBG cord-010092-uftc8inx 11962 21 synthetic synthetic JJ cord-010092-uftc8inx 11962 22 data datum NNS cord-010092-uftc8inx 11962 23 for for IN cord-010092-uftc8inx 11962 24 analysis analysis NN cord-010092-uftc8inx 11962 25 that that WDT cord-010092-uftc8inx 11962 26 does do VBZ cord-010092-uftc8inx 11962 27 not not RB cord-010092-uftc8inx 11962 28 require require VB cord-010092-uftc8inx 11962 29 IRB IRB NNP cord-010092-uftc8inx 11962 30 approval approval NN cord-010092-uftc8inx 11962 31 . . . cord-010092-uftc8inx 11963 1 Results result NNS cord-010092-uftc8inx 11963 2 : : : cord-010092-uftc8inx 11964 1 During during IN cord-010092-uftc8inx 11964 2 the the DT cord-010092-uftc8inx 11964 3 evaluated evaluate VBN cord-010092-uftc8inx 11964 4 period period NN cord-010092-uftc8inx 11964 5 , , , cord-010092-uftc8inx 11964 6 2591 2591 CD cord-010092-uftc8inx 11964 7 patients patient NNS cord-010092-uftc8inx 11964 8 underwent undergo VBD cord-010092-uftc8inx 11964 9 hip hip NN cord-010092-uftc8inx 11964 10 or or CC cord-010092-uftc8inx 11964 11 knee knee NN cord-010092-uftc8inx 11964 12 surgery surgery NN cord-010092-uftc8inx 11964 13 ; ; : cord-010092-uftc8inx 11964 14 231 231 CD cord-010092-uftc8inx 11964 15 were be VBD cord-010092-uftc8inx 11964 16 excluded exclude VBN cord-010092-uftc8inx 11964 17 from from IN cord-010092-uftc8inx 11964 18 the the DT cord-010092-uftc8inx 11964 19 analysis analysis NN cord-010092-uftc8inx 11964 20 due due JJ cord-010092-uftc8inx 11964 21 to to IN cord-010092-uftc8inx 11964 22 receiving receive VBG cord-010092-uftc8inx 11964 23 > > XX cord-010092-uftc8inx 11964 24 1 1 CD cord-010092-uftc8inx 11964 25 blood blood NN cord-010092-uftc8inx 11964 26 unit unit NN cord-010092-uftc8inx 11964 27 . . . cord-010092-uftc8inx 11965 1 Hb Hb NNP cord-010092-uftc8inx 11965 2 measurement measurement NN cord-010092-uftc8inx 11965 3 within within IN cord-010092-uftc8inx 11965 4 90 90 CD cord-010092-uftc8inx 11965 5 days day NNS cord-010092-uftc8inx 11965 6 pre pre JJ cord-010092-uftc8inx 11965 7 - - NN cord-010092-uftc8inx 11965 8 surgery surgery NN cord-010092-uftc8inx 11965 9 was be VBD cord-010092-uftc8inx 11965 10 available available JJ cord-010092-uftc8inx 11965 11 for for IN cord-010092-uftc8inx 11965 12 1202 1202 CD cord-010092-uftc8inx 11965 13 patients patient NNS cord-010092-uftc8inx 11965 14 . . . cord-010092-uftc8inx 11966 1 Hip hip NN cord-010092-uftc8inx 11966 2 or or CC cord-010092-uftc8inx 11966 3 knee knee NN cord-010092-uftc8inx 11966 4 surgery surgery NN cord-010092-uftc8inx 11966 5 was be VBD cord-010092-uftc8inx 11966 6 performed perform VBN cord-010092-uftc8inx 11966 7 in in IN cord-010092-uftc8inx 11966 8 588 588 CD cord-010092-uftc8inx 11966 9 ( ( -LRB- cord-010092-uftc8inx 11966 10 49 49 CD cord-010092-uftc8inx 11966 11 % % NN cord-010092-uftc8inx 11966 12 ) ) -RRB- cord-010092-uftc8inx 11966 13 and and CC cord-010092-uftc8inx 11966 14 614 614 CD cord-010092-uftc8inx 11966 15 ( ( -LRB- cord-010092-uftc8inx 11966 16 51 51 CD cord-010092-uftc8inx 11966 17 % % NN cord-010092-uftc8inx 11966 18 ) ) -RRB- cord-010092-uftc8inx 11966 19 patients patient NNS cord-010092-uftc8inx 11966 20 , , , cord-010092-uftc8inx 11966 21 respectively respectively RB cord-010092-uftc8inx 11966 22 . . . cord-010092-uftc8inx 11967 1 Women woman NNS cord-010092-uftc8inx 11967 2 comprised comprise VBD cord-010092-uftc8inx 11967 3 60 60 CD cord-010092-uftc8inx 11967 4 % % NN cord-010092-uftc8inx 11967 5 ( ( -LRB- cord-010092-uftc8inx 11967 6 n n NN cord-010092-uftc8inx 11967 7 = = SYM cord-010092-uftc8inx 11967 8 356 356 CD cord-010092-uftc8inx 11967 9 ) ) -RRB- cord-010092-uftc8inx 11967 10 of of IN cord-010092-uftc8inx 11967 11 patients patient NNS cord-010092-uftc8inx 11967 12 who who WP cord-010092-uftc8inx 11967 13 underwent undergo VBD cord-010092-uftc8inx 11967 14 hip hip NN cord-010092-uftc8inx 11967 15 surgery surgery NN cord-010092-uftc8inx 11967 16 . . . cord-010092-uftc8inx 11968 1 In in IN cord-010092-uftc8inx 11968 2 the the DT cord-010092-uftc8inx 11968 3 hip hip NN cord-010092-uftc8inx 11968 4 - - HYPH cord-010092-uftc8inx 11968 5 surgery surgery NN cord-010092-uftc8inx 11968 6 group group NN cord-010092-uftc8inx 11968 7 , , , cord-010092-uftc8inx 11968 8 14.5 14.5 CD cord-010092-uftc8inx 11968 9 % % NN cord-010092-uftc8inx 11968 10 of of IN cord-010092-uftc8inx 11968 11 patients patient NNS cord-010092-uftc8inx 11968 12 required require VBN cord-010092-uftc8inx 11968 13 BT BT NNP cord-010092-uftc8inx 11968 14 , , , cord-010092-uftc8inx 11968 15 with with IN cord-010092-uftc8inx 11968 16 this this DT cord-010092-uftc8inx 11968 17 need need NN cord-010092-uftc8inx 11968 18 being be VBG cord-010092-uftc8inx 11968 19 slightly slightly RB cord-010092-uftc8inx 11968 20 higher high JJR cord-010092-uftc8inx 11968 21 among among IN cord-010092-uftc8inx 11968 22 women woman NNS cord-010092-uftc8inx 11968 23 ( ( -LRB- cord-010092-uftc8inx 11968 24 31.5 31.5 CD cord-010092-uftc8inx 11968 25 % % NN cord-010092-uftc8inx 11968 26 vs. vs. CC cord-010092-uftc8inx 11968 27 26.2 26.2 CD cord-010092-uftc8inx 11968 28 % % NN cord-010092-uftc8inx 11968 29 ; ; : cord-010092-uftc8inx 11968 30 P p NN cord-010092-uftc8inx 11968 31 - - HYPH cord-010092-uftc8inx 11968 32 value value NN cord-010092-uftc8inx 11968 33 = = NFP cord-010092-uftc8inx 11968 34 NS NS NNP cord-010092-uftc8inx 11968 35 ) ) -RRB- cord-010092-uftc8inx 11968 36 . . . cord-010092-uftc8inx 11969 1 Only only RB cord-010092-uftc8inx 11969 2 50 50 CD cord-010092-uftc8inx 11969 3 ( ( -LRB- cord-010092-uftc8inx 11969 4 8 8 CD cord-010092-uftc8inx 11969 5 % % NN cord-010092-uftc8inx 11969 6 ) ) -RRB- cord-010092-uftc8inx 11969 7 patients patient NNS cord-010092-uftc8inx 11969 8 were be VBD cord-010092-uftc8inx 11969 9 transfused transfuse VBN cord-010092-uftc8inx 11969 10 during during IN cord-010092-uftc8inx 11969 11 knee knee NN cord-010092-uftc8inx 11969 12 surgery surgery NN cord-010092-uftc8inx 11969 13 and and CC cord-010092-uftc8inx 11969 14 this this DT cord-010092-uftc8inx 11969 15 cohort cohort NN cord-010092-uftc8inx 11969 16 was be VBD cord-010092-uftc8inx 11969 17 not not RB cord-010092-uftc8inx 11969 18 further further RB cord-010092-uftc8inx 11969 19 analyzed analyze VBN cord-010092-uftc8inx 11969 20 . . . cord-010092-uftc8inx 11970 1 Patients patient NNS cord-010092-uftc8inx 11970 2 receiving receive VBG cord-010092-uftc8inx 11970 3 BT BT NNP cord-010092-uftc8inx 11970 4 had have VBD cord-010092-uftc8inx 11970 5 a a DT cord-010092-uftc8inx 11970 6 significantly significantly RB cord-010092-uftc8inx 11970 7 lower low JJR cord-010092-uftc8inx 11970 8 mean mean JJ cord-010092-uftc8inx 11970 9 Hb Hb NNP cord-010092-uftc8inx 11970 10 level level NN cord-010092-uftc8inx 11970 11 than than IN cord-010092-uftc8inx 11970 12 those those DT cord-010092-uftc8inx 11970 13 who who WP cord-010092-uftc8inx 11970 14 did do VBD cord-010092-uftc8inx 11970 15 n't not RB cord-010092-uftc8inx 11970 16 require require VB cord-010092-uftc8inx 11970 17 it -PRON- PRP cord-010092-uftc8inx 11970 18 ( ( -LRB- cord-010092-uftc8inx 11970 19 11.93 11.93 CD cord-010092-uftc8inx 11970 20 g g NN cord-010092-uftc8inx 11970 21 / / SYM cord-010092-uftc8inx 11970 22 dL dl NN cord-010092-uftc8inx 11970 23 versus versus IN cord-010092-uftc8inx 11970 24 12.8 12.8 CD cord-010092-uftc8inx 11970 25 g g NN cord-010092-uftc8inx 11970 26 / / SYM cord-010092-uftc8inx 11970 27 dL dl NN cord-010092-uftc8inx 11970 28 for for IN cord-010092-uftc8inx 11970 29 women woman NNS cord-010092-uftc8inx 11970 30 and and CC cord-010092-uftc8inx 11970 31 12.3 12.3 CD cord-010092-uftc8inx 11970 32 g g NN cord-010092-uftc8inx 11970 33 / / SYM cord-010092-uftc8inx 11970 34 dL dl NN cord-010092-uftc8inx 11971 1 vs. vs. FW cord-010092-uftc8inx 11972 1 13.8 13.8 CD cord-010092-uftc8inx 11972 2 g g NN cord-010092-uftc8inx 11972 3 / / SYM cord-010092-uftc8inx 11972 4 dL dl NN cord-010092-uftc8inx 11972 5 for for IN cord-010092-uftc8inx 11972 6 men man NNS cord-010092-uftc8inx 11972 7 ; ; . cord-010092-uftc8inx 11973 1 P p NN cord-010092-uftc8inx 11973 2 - - HYPH cord-010092-uftc8inx 11973 3 value value NN cord-010092-uftc8inx 11973 4 < < XX cord-010092-uftc8inx 11973 5 0.001 0.001 CD cord-010092-uftc8inx 11973 6 ) ) -RRB- cord-010092-uftc8inx 11973 7 . . . cord-010092-uftc8inx 11974 1 Hospitalization hospitalization NN cord-010092-uftc8inx 11974 2 was be VBD cord-010092-uftc8inx 11974 3 longer long JJR cord-010092-uftc8inx 11974 4 in in IN cord-010092-uftc8inx 11974 5 transfused transfuse VBN cord-010092-uftc8inx 11974 6 patients patient NNS cord-010092-uftc8inx 11974 7 compared compare VBN cord-010092-uftc8inx 11974 8 to to IN cord-010092-uftc8inx 11974 9 non non JJ cord-010092-uftc8inx 11974 10 - - JJ cord-010092-uftc8inx 11974 11 transfused transfused JJ cord-010092-uftc8inx 11974 12 ones one NNS cord-010092-uftc8inx 11974 13 ( ( -LRB- cord-010092-uftc8inx 11974 14 mean mean VB cord-010092-uftc8inx 11974 15 7.52 7.52 CD cord-010092-uftc8inx 11974 16 vs. vs. NN cord-010092-uftc8inx 11974 17 6.91 6.91 CD cord-010092-uftc8inx 11974 18 days day NNS cord-010092-uftc8inx 11974 19 , , , cord-010092-uftc8inx 11974 20 P p NN cord-010092-uftc8inx 11974 21 - - HYPH cord-010092-uftc8inx 11974 22 value value NN cord-010092-uftc8inx 11974 23 = = SYM cord-010092-uftc8inx 11974 24 0.018 0.018 CD cord-010092-uftc8inx 11974 25 ) ) -RRB- cord-010092-uftc8inx 11975 1 and and CC cord-010092-uftc8inx 11975 2 in in IN cord-010092-uftc8inx 11975 3 patients patient NNS cord-010092-uftc8inx 11975 4 with with IN cord-010092-uftc8inx 11975 5 a a DT cord-010092-uftc8inx 11975 6 low low JJ cord-010092-uftc8inx 11975 7 Hb Hb NNP cord-010092-uftc8inx 11975 8 level level NN cord-010092-uftc8inx 11975 9 ( ( -LRB- cord-010092-uftc8inx 11975 10 female female JJ cord-010092-uftc8inx 11975 11 < < XX cord-010092-uftc8inx 11975 12 12 12 CD cord-010092-uftc8inx 11975 13 , , , cord-010092-uftc8inx 11975 14 male male JJ cord-010092-uftc8inx 11975 15 < < XX cord-010092-uftc8inx 11975 16 13.5 13.5 CD cord-010092-uftc8inx 11975 17 ) ) -RRB- cord-010092-uftc8inx 11975 18 than than IN cord-010092-uftc8inx 11975 19 in in IN cord-010092-uftc8inx 11975 20 those those DT cord-010092-uftc8inx 11975 21 with with IN cord-010092-uftc8inx 11975 22 a a DT cord-010092-uftc8inx 11975 23 high high JJ cord-010092-uftc8inx 11975 24 Hb Hb NNP cord-010092-uftc8inx 11975 25 level level NN cord-010092-uftc8inx 11975 26 , , , cord-010092-uftc8inx 11975 27 irrespective irrespective RB cord-010092-uftc8inx 11975 28 of of IN cord-010092-uftc8inx 11975 29 receiving receive VBG cord-010092-uftc8inx 11975 30 BT BT NNP cord-010092-uftc8inx 11975 31 ( ( -LRB- cord-010092-uftc8inx 11975 32 P p NN cord-010092-uftc8inx 11975 33 - - HYPH cord-010092-uftc8inx 11975 34 values value NNS cord-010092-uftc8inx 11975 35 < < XX cord-010092-uftc8inx 11975 36 0.00045 0.00045 CD cord-010092-uftc8inx 11975 37 ) ) -RRB- cord-010092-uftc8inx 11975 38 . . . cord-010092-uftc8inx 11976 1 Patients patient NNS cord-010092-uftc8inx 11976 2 with with IN cord-010092-uftc8inx 11976 3 at at RB cord-010092-uftc8inx 11976 4 least least RBS cord-010092-uftc8inx 11976 5 one one CD cord-010092-uftc8inx 11976 6 of of IN cord-010092-uftc8inx 11976 7 the the DT cord-010092-uftc8inx 11976 8 following follow VBG cord-010092-uftc8inx 11976 9 diagnoses diagnosis NNS cord-010092-uftc8inx 11976 10 : : : cord-010092-uftc8inx 11976 11 diabetes diabetes NN cord-010092-uftc8inx 11976 12 , , , cord-010092-uftc8inx 11976 13 renal renal JJ cord-010092-uftc8inx 11976 14 failure failure NN cord-010092-uftc8inx 11976 15 , , , cord-010092-uftc8inx 11976 16 ischemic ischemic JJ cord-010092-uftc8inx 11976 17 heart heart NN cord-010092-uftc8inx 11976 18 disease disease NN cord-010092-uftc8inx 11976 19 , , , cord-010092-uftc8inx 11976 20 were be VBD cord-010092-uftc8inx 11976 21 significantly significantly RB cord-010092-uftc8inx 11976 22 more more RBR cord-010092-uftc8inx 11976 23 likely likely JJ cord-010092-uftc8inx 11976 24 to to TO cord-010092-uftc8inx 11976 25 have have VB cord-010092-uftc8inx 11976 26 a a DT cord-010092-uftc8inx 11976 27 lower low JJR cord-010092-uftc8inx 11976 28 preoperative preoperative JJ cord-010092-uftc8inx 11976 29 Hb Hb NNP cord-010092-uftc8inx 11976 30 level level NN cord-010092-uftc8inx 11976 31 ( ( -LRB- cord-010092-uftc8inx 11976 32 P p NN cord-010092-uftc8inx 11976 33 - - HYPH cord-010092-uftc8inx 11976 34 value value NN cord-010092-uftc8inx 11976 35 < < XX cord-010092-uftc8inx 11976 36 0.05 0.05 CD cord-010092-uftc8inx 11976 37 ) ) -RRB- cord-010092-uftc8inx 11976 38 . . . cord-010092-uftc8inx 11977 1 No no DT cord-010092-uftc8inx 11977 2 other other JJ cord-010092-uftc8inx 11977 3 factors factor NNS cord-010092-uftc8inx 11977 4 ( ( -LRB- cord-010092-uftc8inx 11977 5 e.g. e.g. RB cord-010092-uftc8inx 11977 6 , , , cord-010092-uftc8inx 11977 7 patient patient NN cord-010092-uftc8inx 11977 8 's 's POS cord-010092-uftc8inx 11977 9 weight weight NN cord-010092-uftc8inx 11977 10 , , , cord-010092-uftc8inx 11977 11 RDW RDW NNP cord-010092-uftc8inx 11977 12 value value NN cord-010092-uftc8inx 11977 13 or or CC cord-010092-uftc8inx 11977 14 blood blood NN cord-010092-uftc8inx 11977 15 pressure pressure NN cord-010092-uftc8inx 11977 16 ) ) -RRB- cord-010092-uftc8inx 11977 17 were be VBD cord-010092-uftc8inx 11977 18 predictive predictive JJ cord-010092-uftc8inx 11977 19 of of IN cord-010092-uftc8inx 11977 20 transfusion transfusion NN cord-010092-uftc8inx 11977 21 need need NN cord-010092-uftc8inx 11977 22 . . . cord-010092-uftc8inx 11978 1 The the DT cord-010092-uftc8inx 11978 2 probability probability NN cord-010092-uftc8inx 11978 3 of of IN cord-010092-uftc8inx 11978 4 a a DT cord-010092-uftc8inx 11978 5 need need NN cord-010092-uftc8inx 11978 6 for for IN cord-010092-uftc8inx 11978 7 1 1 CD cord-010092-uftc8inx 11978 8 blood blood NN cord-010092-uftc8inx 11978 9 unit unit NN cord-010092-uftc8inx 11978 10 was be VBD cord-010092-uftc8inx 11978 11 0.43 0.43 CD cord-010092-uftc8inx 11978 12 in in IN cord-010092-uftc8inx 11978 13 the the DT cord-010092-uftc8inx 11978 14 Hb Hb NNP cord-010092-uftc8inx 11978 15 11 11 CD cord-010092-uftc8inx 11978 16 g g NNP cord-010092-uftc8inx 11978 17 / / SYM cord-010092-uftc8inx 11978 18 dL dl NN cord-010092-uftc8inx 11978 19 group group NN cord-010092-uftc8inx 11978 20 and and CC cord-010092-uftc8inx 11978 21 0.15 0.15 CD cord-010092-uftc8inx 11978 22 in in IN cord-010092-uftc8inx 11978 23 Hb Hb NNP cord-010092-uftc8inx 11978 24 13 13 CD cord-010092-uftc8inx 11978 25 g/ g/ JJ cord-010092-uftc8inx 11978 26 dL dl NN cord-010092-uftc8inx 11978 27 group group NN cord-010092-uftc8inx 11978 28 ( ( -LRB- cord-010092-uftc8inx 11978 29 35%>reduction 35%>reduction CD cord-010092-uftc8inx 11978 30 ) ) -RRB- cord-010092-uftc8inx 11978 31 . . . cord-010092-uftc8inx 11979 1 Summary Summary NNP cord-010092-uftc8inx 11979 2 / / SYM cord-010092-uftc8inx 11979 3 Conclusions conclusion NNS cord-010092-uftc8inx 11979 4 : : : cord-010092-uftc8inx 11979 5 Anemia anemia NN cord-010092-uftc8inx 11979 6 presence presence NN cord-010092-uftc8inx 11979 7 before before IN cord-010092-uftc8inx 11979 8 elective elective JJ cord-010092-uftc8inx 11979 9 hip hip NN cord-010092-uftc8inx 11979 10 surgery surgery NN cord-010092-uftc8inx 11979 11 is be VBZ cord-010092-uftc8inx 11979 12 a a DT cord-010092-uftc8inx 11979 13 risk risk NN cord-010092-uftc8inx 11979 14 factor factor NN cord-010092-uftc8inx 11979 15 for for IN cord-010092-uftc8inx 11979 16 BT BT NNP cord-010092-uftc8inx 11979 17 requirement requirement NN cord-010092-uftc8inx 11979 18 and and CC cord-010092-uftc8inx 11979 19 longer long JJR cord-010092-uftc8inx 11979 20 hospitalization hospitalization NN cord-010092-uftc8inx 11979 21 . . . cord-010092-uftc8inx 11980 1 Diagnosis diagnosis NN cord-010092-uftc8inx 11980 2 and and CC cord-010092-uftc8inx 11980 3 management management NN cord-010092-uftc8inx 11980 4 of of IN cord-010092-uftc8inx 11980 5 anemia anemia NN cord-010092-uftc8inx 11980 6 using use VBG cord-010092-uftc8inx 11980 7 timely timely JJ cord-010092-uftc8inx 11980 8 pre pre JJ cord-010092-uftc8inx 11980 9 - - JJ cord-010092-uftc8inx 11980 10 surgery surgery JJ cord-010092-uftc8inx 11980 11 consultations consultation NNS cord-010092-uftc8inx 11980 12 may may MD cord-010092-uftc8inx 11980 13 minimize minimize VB cord-010092-uftc8inx 11980 14 intraoperative intraoperative JJ cord-010092-uftc8inx 11980 15 BT BT NNP cord-010092-uftc8inx 11980 16 , , , cord-010092-uftc8inx 11980 17 particularly particularly RB cord-010092-uftc8inx 11980 18 in in IN cord-010092-uftc8inx 11980 19 women woman NNS cord-010092-uftc8inx 11980 20 and and CC cord-010092-uftc8inx 11980 21 patients patient NNS cord-010092-uftc8inx 11980 22 with with IN cord-010092-uftc8inx 11980 23 comorbidities comorbiditie NNS cord-010092-uftc8inx 11980 24 . . . cord-010092-uftc8inx 11981 1 Real real JJ cord-010092-uftc8inx 11981 2 - - HYPH cord-010092-uftc8inx 11981 3 patient patient NN cord-010092-uftc8inx 11981 4 data datum NNS cord-010092-uftc8inx 11981 5 and and CC cord-010092-uftc8inx 11981 6 prospective prospective JJ cord-010092-uftc8inx 11981 7 trials trial NNS cord-010092-uftc8inx 11981 8 are be VBP cord-010092-uftc8inx 11981 9 warranted warrant VBN cord-010092-uftc8inx 11981 10 . . . cord-010092-uftc8inx 11982 1 Abstract Abstract NNP cord-010092-uftc8inx 11982 2 withdrawn withdraw VBN cord-010092-uftc8inx 11982 3 . . . cord-010092-uftc8inx 11983 1 Abstract Abstract NNP cord-010092-uftc8inx 11983 2 withdrawn withdraw VBN cord-010092-uftc8inx 11983 3 . . . cord-010092-uftc8inx 11984 1 Background background NN cord-010092-uftc8inx 11984 2 : : : cord-010092-uftc8inx 11985 1 CD36 CD36 NNP cord-010092-uftc8inx 11985 2 , , , cord-010092-uftc8inx 11985 3 known know VBN cord-010092-uftc8inx 11985 4 as as IN cord-010092-uftc8inx 11985 5 platelet platelet NN cord-010092-uftc8inx 11985 6 glycoprotein glycoprotein NN cord-010092-uftc8inx 11985 7 IV IV NNP cord-010092-uftc8inx 11985 8 , , , cord-010092-uftc8inx 11985 9 belongs belong VBZ cord-010092-uftc8inx 11985 10 to to TO cord-010092-uftc8inx 11985 11 type type VB cord-010092-uftc8inx 11985 12 B b NN cord-010092-uftc8inx 11985 13 scavenger scavenger NN cord-010092-uftc8inx 11985 14 receptor receptor NN cord-010092-uftc8inx 11985 15 and and CC cord-010092-uftc8inx 11985 16 is be VBZ cord-010092-uftc8inx 11985 17 related relate VBN cord-010092-uftc8inx 11985 18 to to IN cord-010092-uftc8inx 11985 19 the the DT cord-010092-uftc8inx 11985 20 pathogenesis pathogenesis NN cord-010092-uftc8inx 11985 21 of of IN cord-010092-uftc8inx 11985 22 many many JJ cord-010092-uftc8inx 11985 23 diseases disease NNS cord-010092-uftc8inx 11985 24 . . . cord-010092-uftc8inx 11986 1 Type type NN cord-010092-uftc8inx 11986 2 I -PRON- PRP cord-010092-uftc8inx 11986 3 CD36 CD36 NNP cord-010092-uftc8inx 11986 4 deficiency deficiency NN cord-010092-uftc8inx 11986 5 was be VBD cord-010092-uftc8inx 11986 6 CD36 CD36 NNP cord-010092-uftc8inx 11986 7 not not RB cord-010092-uftc8inx 11986 8 expressed express VBN cord-010092-uftc8inx 11986 9 on on IN cord-010092-uftc8inx 11986 10 platelets platelet NNS cord-010092-uftc8inx 11986 11 and and CC cord-010092-uftc8inx 11986 12 monocytes monocyte NNS cord-010092-uftc8inx 11986 13 . . . cord-010092-uftc8inx 11987 1 Individuals individual NNS cord-010092-uftc8inx 11987 2 with with IN cord-010092-uftc8inx 11987 3 type type NN cord-010092-uftc8inx 11987 4 I -PRON- PRP cord-010092-uftc8inx 11987 5 deficiency deficiency NN cord-010092-uftc8inx 11987 6 can can MD cord-010092-uftc8inx 11987 7 produce produce VB cord-010092-uftc8inx 11987 8 homologous homologous JJ cord-010092-uftc8inx 11987 9 antibodies antibody NNS cord-010092-uftc8inx 11987 10 and and CC cord-010092-uftc8inx 11987 11 cause cause VB cord-010092-uftc8inx 11987 12 related related JJ cord-010092-uftc8inx 11987 13 immune immune JJ cord-010092-uftc8inx 11987 14 diseases disease NNS cord-010092-uftc8inx 11987 15 . . . cord-010092-uftc8inx 11988 1 In in IN cord-010092-uftc8inx 11988 2 recent recent JJ cord-010092-uftc8inx 11988 3 years year NNS cord-010092-uftc8inx 11988 4 , , , cord-010092-uftc8inx 11988 5 it -PRON- PRP cord-010092-uftc8inx 11988 6 has have VBZ cord-010092-uftc8inx 11988 7 been be VBN cord-010092-uftc8inx 11988 8 reported report VBN cord-010092-uftc8inx 11988 9 that that IN cord-010092-uftc8inx 11988 10 CD36 CD36 NNP cord-010092-uftc8inx 11988 11 deficient deficient JJ cord-010092-uftc8inx 11988 12 individuals individual NNS cord-010092-uftc8inx 11988 13 cause cause VBP cord-010092-uftc8inx 11988 14 fetal fetal JJ cord-010092-uftc8inx 11988 15 immune immune JJ cord-010092-uftc8inx 11988 16 thrombocytopenia thrombocytopenia NN cord-010092-uftc8inx 11988 17 with with IN cord-010092-uftc8inx 11988 18 fetal fetal JJ cord-010092-uftc8inx 11988 19 edema edema NN cord-010092-uftc8inx 11988 20 syndrome syndrome NN cord-010092-uftc8inx 11988 21 in in IN cord-010092-uftc8inx 11988 22 Asia Asia NNP cord-010092-uftc8inx 11988 23 . . . cord-010092-uftc8inx 11989 1 CD36 CD36 NNP cord-010092-uftc8inx 11989 2 is be VBZ cord-010092-uftc8inx 11989 3 not not RB cord-010092-uftc8inx 11989 4 expressed express VBN cord-010092-uftc8inx 11989 5 in in IN cord-010092-uftc8inx 11989 6 mature mature JJ cord-010092-uftc8inx 11989 7 RBC RBC NNP cord-010092-uftc8inx 11989 8 , , , cord-010092-uftc8inx 11989 9 but but CC cord-010092-uftc8inx 11989 10 exists exist VBZ cord-010092-uftc8inx 11989 11 in in IN cord-010092-uftc8inx 11989 12 hematopoietic hematopoietic JJ cord-010092-uftc8inx 11989 13 stem stem NN cord-010092-uftc8inx 11989 14 ( ( -LRB- cord-010092-uftc8inx 11989 15 progenitor progenitor NN cord-010092-uftc8inx 11989 16 ) ) -RRB- cord-010092-uftc8inx 11989 17 cells cell NNS cord-010092-uftc8inx 11989 18 . . . cord-010092-uftc8inx 11990 1 Anemia anemia NN cord-010092-uftc8inx 11990 2 is be VBZ cord-010092-uftc8inx 11990 3 an an DT cord-010092-uftc8inx 11990 4 important important JJ cord-010092-uftc8inx 11990 5 cause cause NN cord-010092-uftc8inx 11990 6 of of IN cord-010092-uftc8inx 11990 7 edema edema NN cord-010092-uftc8inx 11990 8 . . . cord-010092-uftc8inx 11991 1 In in IN cord-010092-uftc8inx 11991 2 view view NN cord-010092-uftc8inx 11991 3 of of IN cord-010092-uftc8inx 11991 4 the the DT cord-010092-uftc8inx 11991 5 phenomena phenomenon NNS cord-010092-uftc8inx 11991 6 of of IN cord-010092-uftc8inx 11991 7 clinical clinical JJ cord-010092-uftc8inx 11991 8 and and CC cord-010092-uftc8inx 11991 9 animal animal NN cord-010092-uftc8inx 11991 10 experiments experiment NNS cord-010092-uftc8inx 11991 11 , , , cord-010092-uftc8inx 11991 12 CD34 CD34 NNP cord-010092-uftc8inx 11991 13 + + CC cord-010092-uftc8inx 11991 14 hematopoietic hematopoietic JJ cord-010092-uftc8inx 11991 15 stem stem NN cord-010092-uftc8inx 11991 16 ( ( -LRB- cord-010092-uftc8inx 11991 17 progenitor progenitor NN cord-010092-uftc8inx 11991 18 ) ) -RRB- cord-010092-uftc8inx 11991 19 cells cell NNS cord-010092-uftc8inx 11991 20 were be VBD cord-010092-uftc8inx 11991 21 cultured culture VBN cord-010092-uftc8inx 11991 22 in in IN cord-010092-uftc8inx 11991 23 vitro vitro FW cord-010092-uftc8inx 11991 24 to to TO cord-010092-uftc8inx 11991 25 observe observe VB cord-010092-uftc8inx 11991 26 the the DT cord-010092-uftc8inx 11991 27 effect effect NN cord-010092-uftc8inx 11991 28 of of IN cord-010092-uftc8inx 11991 29 anti anti JJ cord-010092-uftc8inx 11991 30 - - JJ cord-010092-uftc8inx 11991 31 CD36 cd36 JJ cord-010092-uftc8inx 11991 32 monoclonal monoclonal JJ cord-010092-uftc8inx 11991 33 antibody antibody NN cord-010092-uftc8inx 11991 34 on on IN cord-010092-uftc8inx 11991 35 CD34 CD34 NNP cord-010092-uftc8inx 11992 1 + + SYM cord-010092-uftc8inx 11992 2 hematopoietic hematopoietic JJ cord-010092-uftc8inx 11992 3 stem stem NN cord-010092-uftc8inx 11992 4 ( ( -LRB- cord-010092-uftc8inx 11992 5 progenitor progenitor NN cord-010092-uftc8inx 11992 6 ) ) -RRB- cord-010092-uftc8inx 11992 7 cells cell NNS cord-010092-uftc8inx 11992 8 . . . cord-010092-uftc8inx 11993 1 Aims aim VBZ cord-010092-uftc8inx 11993 2 : : : cord-010092-uftc8inx 11993 3 To to TO cord-010092-uftc8inx 11993 4 investigate investigate VB cord-010092-uftc8inx 11993 5 the the DT cord-010092-uftc8inx 11993 6 effect effect NN cord-010092-uftc8inx 11993 7 of of IN cord-010092-uftc8inx 11993 8 anti anti JJ cord-010092-uftc8inx 11993 9 - - JJ cord-010092-uftc8inx 11993 10 CD36 cd36 JJ cord-010092-uftc8inx 11993 11 monoclonal monoclonal JJ cord-010092-uftc8inx 11993 12 antibody antibody NN cord-010092-uftc8inx 11993 13 on on IN cord-010092-uftc8inx 11993 14 proliferation proliferation NN cord-010092-uftc8inx 11993 15 and and CC cord-010092-uftc8inx 11993 16 differentiation differentiation NN cord-010092-uftc8inx 11993 17 of of IN cord-010092-uftc8inx 11993 18 human human JJ cord-010092-uftc8inx 11993 19 CD34 CD34 NNP cord-010092-uftc8inx 11993 20 + + CC cord-010092-uftc8inx 11993 21 hematopoietic hematopoietic JJ cord-010092-uftc8inx 11993 22 stem stem NN cord-010092-uftc8inx 11993 23 ( ( -LRB- cord-010092-uftc8inx 11993 24 progenitor progenitor NN cord-010092-uftc8inx 11993 25 ) ) -RRB- cord-010092-uftc8inx 11993 26 cells cell NNS cord-010092-uftc8inx 11993 27 in in IN cord-010092-uftc8inx 11993 28 vitro vitro FW cord-010092-uftc8inx 11993 29 . . . cord-010092-uftc8inx 11994 1 Methods method NNS cord-010092-uftc8inx 11994 2 : : : cord-010092-uftc8inx 11994 3 Choose choose VB cord-010092-uftc8inx 11994 4 3 3 CD cord-010092-uftc8inx 11994 5 healthy healthy JJ cord-010092-uftc8inx 11994 6 full full JJ cord-010092-uftc8inx 11994 7 - - HYPH cord-010092-uftc8inx 11994 8 term term NN cord-010092-uftc8inx 11994 9 maternal maternal JJ cord-010092-uftc8inx 11994 10 women woman NNS cord-010092-uftc8inx 11994 11 without without IN cord-010092-uftc8inx 11994 12 various various JJ cord-010092-uftc8inx 11994 13 obstetric obstetric JJ cord-010092-uftc8inx 11994 14 complications complication NNS cord-010092-uftc8inx 11994 15 , , , cord-010092-uftc8inx 11994 16 take take VB cord-010092-uftc8inx 11994 17 cord cord NN cord-010092-uftc8inx 11994 18 blood blood NN cord-010092-uftc8inx 11994 19 20 20 CD cord-010092-uftc8inx 11994 20 ml ml NNS cord-010092-uftc8inx 11994 21 . . . cord-010092-uftc8inx 11995 1 After after IN cord-010092-uftc8inx 11995 2 density density NN cord-010092-uftc8inx 11995 3 gradient gradient NN cord-010092-uftc8inx 11995 4 centrifugation centrifugation NN cord-010092-uftc8inx 11995 5 of of IN cord-010092-uftc8inx 11995 6 Ficoll Ficoll NNP cord-010092-uftc8inx 11995 7 cell cell NN cord-010092-uftc8inx 11995 8 separation separation NN cord-010092-uftc8inx 11995 9 solution solution NN cord-010092-uftc8inx 11995 10 , , , cord-010092-uftc8inx 11995 11 CD34 CD34 NNP cord-010092-uftc8inx 11995 12 + + CC cord-010092-uftc8inx 11995 13 hematopoietic hematopoietic JJ cord-010092-uftc8inx 11995 14 stem stem NN cord-010092-uftc8inx 11995 15 ( ( -LRB- cord-010092-uftc8inx 11995 16 progenitor progenitor NN cord-010092-uftc8inx 11995 17 ) ) -RRB- cord-010092-uftc8inx 11995 18 cells cell NNS cord-010092-uftc8inx 11995 19 were be VBD cord-010092-uftc8inx 11995 20 sorted sort VBN cord-010092-uftc8inx 11995 21 by by IN cord-010092-uftc8inx 11995 22 flow flow NN cord-010092-uftc8inx 11995 23 cytometry cytometry NN cord-010092-uftc8inx 11995 24 and and CC cord-010092-uftc8inx 11995 25 cultured culture VBN cord-010092-uftc8inx 11995 26 for for IN cord-010092-uftc8inx 11995 27 2 2 CD cord-010092-uftc8inx 11995 28 - - SYM cord-010092-uftc8inx 11995 29 3 3 CD cord-010092-uftc8inx 11995 30 generations generation NNS cord-010092-uftc8inx 11995 31 . . . cord-010092-uftc8inx 11996 1 MTT MTT NNP cord-010092-uftc8inx 11996 2 was be VBD cord-010092-uftc8inx 11996 3 used use VBN cord-010092-uftc8inx 11996 4 to to TO cord-010092-uftc8inx 11996 5 examine examine VB cord-010092-uftc8inx 11996 6 the the DT cord-010092-uftc8inx 11996 7 effect effect NN cord-010092-uftc8inx 11996 8 of of IN cord-010092-uftc8inx 11996 9 anti anti JJ cord-010092-uftc8inx 11996 10 - - JJ cord-010092-uftc8inx 11996 11 CD36 cd36 JJ cord-010092-uftc8inx 11996 12 monoclonal monoclonal JJ cord-010092-uftc8inx 11996 13 antibody antibody NN cord-010092-uftc8inx 11996 14 on on IN cord-010092-uftc8inx 11996 15 the the DT cord-010092-uftc8inx 11996 16 growth growth NN cord-010092-uftc8inx 11996 17 of of IN cord-010092-uftc8inx 11996 18 hematopoietic hematopoietic JJ cord-010092-uftc8inx 11996 19 stem stem NN cord-010092-uftc8inx 11996 20 ( ( -LRB- cord-010092-uftc8inx 11996 21 progenitor progenitor NN cord-010092-uftc8inx 11996 22 ) ) -RRB- cord-010092-uftc8inx 11996 23 cells cell NNS cord-010092-uftc8inx 11996 24 . . . cord-010092-uftc8inx 11997 1 Flow flow VB cord-010092-uftc8inx 11997 2 Cytometry Cytometry NNP cord-010092-uftc8inx 11997 3 Analysis Analysis NNP cord-010092-uftc8inx 11997 4 was be VBD cord-010092-uftc8inx 11997 5 used use VBN cord-010092-uftc8inx 11997 6 to to TO cord-010092-uftc8inx 11997 7 detect detect VB cord-010092-uftc8inx 11997 8 the the DT cord-010092-uftc8inx 11997 9 apoptosis apoptosis NN cord-010092-uftc8inx 11997 10 and and CC cord-010092-uftc8inx 11997 11 cell cell NN cord-010092-uftc8inx 11997 12 cycle cycle NN cord-010092-uftc8inx 11997 13 of of IN cord-010092-uftc8inx 11997 14 CD34 CD34 NNP cord-010092-uftc8inx 11997 15 + + CC cord-010092-uftc8inx 11997 16 hematopoietic hematopoietic JJ cord-010092-uftc8inx 11997 17 stem stem NN cord-010092-uftc8inx 11997 18 ( ( -LRB- cord-010092-uftc8inx 11997 19 progenitor progenitor NN cord-010092-uftc8inx 11997 20 ) ) -RRB- cord-010092-uftc8inx 11997 21 cells cell NNS cord-010092-uftc8inx 11997 22 . . . cord-010092-uftc8inx 11998 1 The the DT cord-010092-uftc8inx 11998 2 effect effect NN cord-010092-uftc8inx 11998 3 of of IN cord-010092-uftc8inx 11998 4 anti anti JJ cord-010092-uftc8inx 11998 5 - - JJ cord-010092-uftc8inx 11998 6 CD36 cd36 JJ cord-010092-uftc8inx 11998 7 monoclonal monoclonal JJ cord-010092-uftc8inx 11998 8 antibody antibody NN cord-010092-uftc8inx 11998 9 on on IN cord-010092-uftc8inx 11998 10 the the DT cord-010092-uftc8inx 11998 11 formation formation NN cord-010092-uftc8inx 11998 12 of of IN cord-010092-uftc8inx 11998 13 CFU CFU NNP cord-010092-uftc8inx 11998 14 - - HYPH cord-010092-uftc8inx 11998 15 E E NNP cord-010092-uftc8inx 11998 16 / / SYM cord-010092-uftc8inx 11998 17 BFU BFU NNP cord-010092-uftc8inx 11998 18 - - HYPH cord-010092-uftc8inx 11998 19 E E NNP cord-010092-uftc8inx 11998 20 in in IN cord-010092-uftc8inx 11998 21 hematopoietic hematopoietic JJ cord-010092-uftc8inx 11998 22 stem stem NN cord-010092-uftc8inx 11998 23 ( ( -LRB- cord-010092-uftc8inx 11998 24 progenitor progenitor NN cord-010092-uftc8inx 11998 25 ) ) -RRB- cord-010092-uftc8inx 11998 26 cells cell NNS cord-010092-uftc8inx 11998 27 was be VBD cord-010092-uftc8inx 11998 28 analysis analysis NN cord-010092-uftc8inx 11998 29 by by IN cord-010092-uftc8inx 11998 30 CFU CFU NNP cord-010092-uftc8inx 11998 31 - - HYPH cord-010092-uftc8inx 11998 32 E E NNP cord-010092-uftc8inx 11998 33 / / SYM cord-010092-uftc8inx 11998 34 BFU BFU NNP cord-010092-uftc8inx 11998 35 - - HYPH cord-010092-uftc8inx 11998 36 E E NNP cord-010092-uftc8inx 11998 37 account account NN cord-010092-uftc8inx 11998 38 after after IN cord-010092-uftc8inx 11998 39 10 10 CD cord-010092-uftc8inx 11998 40 - - SYM cord-010092-uftc8inx 11998 41 14 14 CD cord-010092-uftc8inx 11998 42 days day NNS cord-010092-uftc8inx 11998 43 culture culture NN cord-010092-uftc8inx 11998 44 . . . cord-010092-uftc8inx 11999 1 Results result NNS cord-010092-uftc8inx 11999 2 : : : cord-010092-uftc8inx 12000 1 After after IN cord-010092-uftc8inx 12000 2 umbilical umbilical JJ cord-010092-uftc8inx 12000 3 cord cord NN cord-010092-uftc8inx 12000 4 blood blood NN cord-010092-uftc8inx 12000 5 was be VBD cord-010092-uftc8inx 12000 6 isolated isolate VBN cord-010092-uftc8inx 12000 7 by by IN cord-010092-uftc8inx 12000 8 Ficoll Ficoll NNP cord-010092-uftc8inx 12000 9 to to TO cord-010092-uftc8inx 12000 10 obtain obtain VB cord-010092-uftc8inx 12000 11 mononuclear mononuclear JJ cord-010092-uftc8inx 12000 12 cells cell NNS cord-010092-uftc8inx 12000 13 , , , cord-010092-uftc8inx 12000 14 the the DT cord-010092-uftc8inx 12000 15 hematopoietic hematopoietic JJ cord-010092-uftc8inx 12000 16 stem stem NN cord-010092-uftc8inx 12000 17 ( ( -LRB- cord-010092-uftc8inx 12000 18 progenitor progenitor NN cord-010092-uftc8inx 12000 19 ) ) -RRB- cord-010092-uftc8inx 12000 20 cells cell NNS cord-010092-uftc8inx 12000 21 of of IN cord-010092-uftc8inx 12000 22 CD34 CD34 NNP cord-010092-uftc8inx 12000 23 + + CC cord-010092-uftc8inx 12000 24 were be VBD cord-010092-uftc8inx 12000 25 sorted sort VBN cord-010092-uftc8inx 12000 26 by by IN cord-010092-uftc8inx 12000 27 flow flow NN cord-010092-uftc8inx 12000 28 cytometry cytometry NN cord-010092-uftc8inx 12000 29 , , , cord-010092-uftc8inx 12000 30 and and CC cord-010092-uftc8inx 12001 1 about about RB cord-010092-uftc8inx 12001 2 0.44 0.44 CD cord-010092-uftc8inx 12001 3 % % NN cord-010092-uftc8inx 12001 4 of of IN cord-010092-uftc8inx 12001 5 CD34 CD34 NNP cord-010092-uftc8inx 12001 6 + + CC cord-010092-uftc8inx 12001 7 hematopoietic hematopoietic JJ cord-010092-uftc8inx 12001 8 stem stem NN cord-010092-uftc8inx 12001 9 ( ( -LRB- cord-010092-uftc8inx 12001 10 progenitor progenitor NN cord-010092-uftc8inx 12001 11 ) ) -RRB- cord-010092-uftc8inx 12001 12 cells cell NNS cord-010092-uftc8inx 12001 13 were be VBD cord-010092-uftc8inx 12001 14 isolated isolate VBN cord-010092-uftc8inx 12001 15 . . . cord-010092-uftc8inx 12002 1 Different different JJ cord-010092-uftc8inx 12002 2 concentrations concentration NNS cord-010092-uftc8inx 12002 3 of of IN cord-010092-uftc8inx 12002 4 anti anti JJ cord-010092-uftc8inx 12002 5 - - JJ cord-010092-uftc8inx 12002 6 CD36 cd36 JJ cord-010092-uftc8inx 12002 7 monoclonal monoclonal JJ cord-010092-uftc8inx 12002 8 antibody antibody NN cord-010092-uftc8inx 12002 9 and and CC cord-010092-uftc8inx 12002 10 hematopoietic hematopoietic JJ cord-010092-uftc8inx 12002 11 stem stem NN cord-010092-uftc8inx 12002 12 ( ( -LRB- cord-010092-uftc8inx 12002 13 progenitor progenitor NN cord-010092-uftc8inx 12002 14 ) ) -RRB- cord-010092-uftc8inx 12002 15 cells cell NNS cord-010092-uftc8inx 12002 16 were be VBD cord-010092-uftc8inx 12002 17 cultured culture VBN cord-010092-uftc8inx 12002 18 in in IN cord-010092-uftc8inx 12002 19 vitro vitro FW cord-010092-uftc8inx 12002 20 . . . cord-010092-uftc8inx 12003 1 The the DT cord-010092-uftc8inx 12003 2 OD OD NNP cord-010092-uftc8inx 12003 3 value value NN cord-010092-uftc8inx 12003 4 of of IN cord-010092-uftc8inx 12003 5 value value NN cord-010092-uftc8inx 12003 6 ( ( -LRB- cord-010092-uftc8inx 12003 7 0.9 0.9 CD cord-010092-uftc8inx 12003 8 AE AE NNP cord-010092-uftc8inx 12003 9 0.15 0.15 CD cord-010092-uftc8inx 12003 10 ) ) -RRB- cord-010092-uftc8inx 12003 11 of of IN cord-010092-uftc8inx 12003 12 anti anti JJ cord-010092-uftc8inx 12003 13 - - JJ cord-010092-uftc8inx 12003 14 CD36 cd36 JJ cord-010092-uftc8inx 12003 15 monoclonal monoclonal JJ cord-010092-uftc8inx 12003 16 antibody antibody NN cord-010092-uftc8inx 12003 17 group group NN cord-010092-uftc8inx 12003 18 ( ( -LRB- cord-010092-uftc8inx 12003 19 2 2 CD cord-010092-uftc8inx 12003 20 mg mg NNP cord-010092-uftc8inx 12003 21 / / SYM cord-010092-uftc8inx 12003 22 ml ml NNP cord-010092-uftc8inx 12003 23 ) ) -RRB- cord-010092-uftc8inx 12003 24 was be VBD cord-010092-uftc8inx 12003 25 decreased decrease VBN cord-010092-uftc8inx 12003 26 than than IN cord-010092-uftc8inx 12003 27 normal normal JJ cord-010092-uftc8inx 12003 28 group group NN cord-010092-uftc8inx 12003 29 ( ( -LRB- cord-010092-uftc8inx 12003 30 1.05 1.05 CD cord-010092-uftc8inx 12003 31 AE AE NNP cord-010092-uftc8inx 12003 32 0.12 0.12 CD cord-010092-uftc8inx 12003 33 ) ) -RRB- cord-010092-uftc8inx 12003 34 ( ( -LRB- cord-010092-uftc8inx 12003 35 P p NN cord-010092-uftc8inx 12003 36 < < XX cord-010092-uftc8inx 12003 37 0.05 0.05 CD cord-010092-uftc8inx 12003 38 ) ) -RRB- cord-010092-uftc8inx 12003 39 , , , cord-010092-uftc8inx 12003 40 and and CC cord-010092-uftc8inx 12003 41 the the DT cord-010092-uftc8inx 12003 42 OD OD NNP cord-010092-uftc8inx 12003 43 value value NN cord-010092-uftc8inx 12003 44 ( ( -LRB- cord-010092-uftc8inx 12003 45 0.81 0.81 CD cord-010092-uftc8inx 12003 46 AE AE NNP cord-010092-uftc8inx 12003 47 0.11 0.11 CD cord-010092-uftc8inx 12003 48 ) ) -RRB- cord-010092-uftc8inx 12003 49 was be VBD cord-010092-uftc8inx 12003 50 significantly significantly RB cord-010092-uftc8inx 12003 51 decreased decrease VBN cord-010092-uftc8inx 12003 52 at at IN cord-010092-uftc8inx 12003 53 the the DT cord-010092-uftc8inx 12003 54 CD36 CD36 NNP cord-010092-uftc8inx 12003 55 monoclonal monoclonal JJ cord-010092-uftc8inx 12003 56 antibody antibody NN cord-010092-uftc8inx 12003 57 concentration concentration NN cord-010092-uftc8inx 12003 58 of of IN cord-010092-uftc8inx 12003 59 32 32 CD cord-010092-uftc8inx 12003 60 mg mg NNP cord-010092-uftc8inx 12003 61 / / SYM cord-010092-uftc8inx 12003 62 ml ml NN cord-010092-uftc8inx 12004 1 ( ( -LRB- cord-010092-uftc8inx 12004 2 P p NN cord-010092-uftc8inx 12004 3 < < XX cord-010092-uftc8inx 12004 4 0.01 0.01 CD cord-010092-uftc8inx 12004 5 ) ) -RRB- cord-010092-uftc8inx 12004 6 . . . cord-010092-uftc8inx 12005 1 There there EX cord-010092-uftc8inx 12005 2 was be VBD cord-010092-uftc8inx 12005 3 no no DT cord-010092-uftc8inx 12005 4 significant significant JJ cord-010092-uftc8inx 12005 5 difference difference NN cord-010092-uftc8inx 12005 6 between between IN cord-010092-uftc8inx 12005 7 the the DT cord-010092-uftc8inx 12005 8 hematopoietic hematopoietic JJ cord-010092-uftc8inx 12005 9 stem stem NN cord-010092-uftc8inx 12005 10 ( ( -LRB- cord-010092-uftc8inx 12005 11 progenitor progenitor NN cord-010092-uftc8inx 12005 12 ) ) -RRB- cord-010092-uftc8inx 12005 13 cells cell NNS cord-010092-uftc8inx 12005 14 culture culture NN cord-010092-uftc8inx 12005 15 group group NN cord-010092-uftc8inx 12005 16 and and CC cord-010092-uftc8inx 12005 17 the the DT cord-010092-uftc8inx 12005 18 IgG IgG NNP cord-010092-uftc8inx 12005 19 control control NNP cord-010092-uftc8inx 12005 20 group group NNP cord-010092-uftc8inx 12005 21 ( ( -LRB- cord-010092-uftc8inx 12005 22 P p NN cord-010092-uftc8inx 12005 23 > > XX cord-010092-uftc8inx 12005 24 0.05 0.05 CD cord-010092-uftc8inx 12005 25 ) ) -RRB- cord-010092-uftc8inx 12005 26 . . . cord-010092-uftc8inx 12006 1 In in IN cord-010092-uftc8inx 12006 2 the the DT cord-010092-uftc8inx 12006 3 Annexin Annexin NNP cord-010092-uftc8inx 12006 4 V V NNP cord-010092-uftc8inx 12006 5 flow flow NN cord-010092-uftc8inx 12006 6 detection detection NN cord-010092-uftc8inx 12006 7 , , , cord-010092-uftc8inx 12006 8 the the DT cord-010092-uftc8inx 12006 9 apoptotic apoptotic JJ cord-010092-uftc8inx 12006 10 rate rate NN cord-010092-uftc8inx 12006 11 of of IN cord-010092-uftc8inx 12006 12 anti anti JJ cord-010092-uftc8inx 12006 13 - - JJ cord-010092-uftc8inx 12006 14 CD36 cd36 JJ cord-010092-uftc8inx 12006 15 monoclonal monoclonal JJ cord-010092-uftc8inx 12006 16 antibody antibody NN cord-010092-uftc8inx 12006 17 group group NN cord-010092-uftc8inx 12006 18 ( ( -LRB- cord-010092-uftc8inx 12006 19 2 2 CD cord-010092-uftc8inx 12006 20 mg mg NNP cord-010092-uftc8inx 12006 21 / / SYM cord-010092-uftc8inx 12006 22 ml ml NNP cord-010092-uftc8inx 12006 23 ) ) -RRB- cord-010092-uftc8inx 12006 24 was be VBD cord-010092-uftc8inx 12006 25 statistically statistically RB cord-010092-uftc8inx 12006 26 increased increase VBN cord-010092-uftc8inx 12006 27 than than IN cord-010092-uftc8inx 12006 28 the the DT cord-010092-uftc8inx 12006 29 normal normal JJ cord-010092-uftc8inx 12006 30 group group NN cord-010092-uftc8inx 12006 31 ( ( -LRB- cord-010092-uftc8inx 12006 32 P p NN cord-010092-uftc8inx 12006 33 < < XX cord-010092-uftc8inx 12006 34 0.05 0.05 CD cord-010092-uftc8inx 12006 35 ) ) -RRB- cord-010092-uftc8inx 12006 36 . . . cord-010092-uftc8inx 12007 1 Anti anti JJ cord-010092-uftc8inx 12007 2 - - JJ cord-010092-uftc8inx 12007 3 CD36 CD36 NNP cord-010092-uftc8inx 12007 4 monoclonal monoclonal JJ cord-010092-uftc8inx 12007 5 antibody antibody NN cord-010092-uftc8inx 12007 6 significantly significantly RB cord-010092-uftc8inx 12007 7 induced induce VBD cord-010092-uftc8inx 12007 8 hematopoietic hematopoietic JJ cord-010092-uftc8inx 12007 9 stem stem NN cord-010092-uftc8inx 12007 10 ( ( -LRB- cord-010092-uftc8inx 12007 11 progenitor progenitor NN cord-010092-uftc8inx 12007 12 ) ) -RRB- cord-010092-uftc8inx 12007 13 cells cell NNS cord-010092-uftc8inx 12007 14 to to TO cord-010092-uftc8inx 12007 15 undergo undergo VB cord-010092-uftc8inx 12007 16 S S NNP cord-010092-uftc8inx 12007 17 phase phase NN cord-010092-uftc8inx 12007 18 cell cell NN cord-010092-uftc8inx 12007 19 reduction reduction NN cord-010092-uftc8inx 12007 20 , , , cord-010092-uftc8inx 12007 21 G1 G1 NNP cord-010092-uftc8inx 12007 22 phase phase NN cord-010092-uftc8inx 12007 23 cells cell NNS cord-010092-uftc8inx 12007 24 increased increase VBD cord-010092-uftc8inx 12007 25 , , , cord-010092-uftc8inx 12007 26 and and CC cord-010092-uftc8inx 12007 27 G1 G1 NNP cord-010092-uftc8inx 12007 28 / / SYM cord-010092-uftc8inx 12007 29 S S NNP cord-010092-uftc8inx 12007 30 phase phase NN cord-010092-uftc8inx 12007 31 cell cell NN cord-010092-uftc8inx 12007 32 arrest arrest NN cord-010092-uftc8inx 12007 33 occurred occur VBD cord-010092-uftc8inx 12007 34 . . . cord-010092-uftc8inx 12008 1 The the DT cord-010092-uftc8inx 12008 2 number number NN cord-010092-uftc8inx 12008 3 of of IN cord-010092-uftc8inx 12008 4 CFU CFU NNP cord-010092-uftc8inx 12008 5 - - HYPH cord-010092-uftc8inx 12008 6 E E NNP cord-010092-uftc8inx 12008 7 / / SYM cord-010092-uftc8inx 12008 8 BFU BFU NNP cord-010092-uftc8inx 12008 9 - - HYPH cord-010092-uftc8inx 12008 10 E E NNP cord-010092-uftc8inx 12008 11 clones clone NNS cord-010092-uftc8inx 12008 12 in in IN cord-010092-uftc8inx 12008 13 the the DT cord-010092-uftc8inx 12008 14 normal normal JJ cord-010092-uftc8inx 12008 15 group group NN cord-010092-uftc8inx 12008 16 was be VBD cord-010092-uftc8inx 12008 17 169 169 CD cord-010092-uftc8inx 12008 18 AE AE NNP cord-010092-uftc8inx 12008 19 12 12 CD cord-010092-uftc8inx 12008 20 , , , cord-010092-uftc8inx 12008 21 the the DT cord-010092-uftc8inx 12008 22 number number NN cord-010092-uftc8inx 12008 23 of of IN cord-010092-uftc8inx 12008 24 CFU CFU NNP cord-010092-uftc8inx 12008 25 - - HYPH cord-010092-uftc8inx 12008 26 E E NNP cord-010092-uftc8inx 12008 27 / / SYM cord-010092-uftc8inx 12008 28 BFU BFU NNP cord-010092-uftc8inx 12008 29 - - HYPH cord-010092-uftc8inx 12008 30 E E NNP cord-010092-uftc8inx 12008 31 clones clone NNS cord-010092-uftc8inx 12008 32 in in IN cord-010092-uftc8inx 12008 33 the the DT cord-010092-uftc8inx 12008 34 control control NN cord-010092-uftc8inx 12008 35 group group NN cord-010092-uftc8inx 12008 36 was be VBD cord-010092-uftc8inx 12008 37 172 172 CD cord-010092-uftc8inx 12008 38 AE AE NNP cord-010092-uftc8inx 12008 39 12 12 CD cord-010092-uftc8inx 12008 40 , , , cord-010092-uftc8inx 12008 41 and and CC cord-010092-uftc8inx 12008 42 the the DT cord-010092-uftc8inx 12008 43 number number NN cord-010092-uftc8inx 12008 44 of of IN cord-010092-uftc8inx 12008 45 CFU CFU NNP cord-010092-uftc8inx 12008 46 - - HYPH cord-010092-uftc8inx 12008 47 E E NNP cord-010092-uftc8inx 12008 48 / / SYM cord-010092-uftc8inx 12008 49 BFU BFU NNP cord-010092-uftc8inx 12008 50 - - HYPH cord-010092-uftc8inx 12008 51 E E NNP cord-010092-uftc8inx 12008 52 clones clone NNS cord-010092-uftc8inx 12008 53 in in IN cord-010092-uftc8inx 12008 54 the the DT cord-010092-uftc8inx 12008 55 anti anti JJ cord-010092-uftc8inx 12008 56 - - JJ cord-010092-uftc8inx 12008 57 CD36 cd36 JJ cord-010092-uftc8inx 12008 58 monoclonal monoclonal JJ cord-010092-uftc8inx 12008 59 antibody antibody NN cord-010092-uftc8inx 12008 60 culture culture NN cord-010092-uftc8inx 12008 61 group group NN cord-010092-uftc8inx 12008 62 was be VBD cord-010092-uftc8inx 12008 63 85 85 CD cord-010092-uftc8inx 12008 64 AE AE NNP cord-010092-uftc8inx 12008 65 6 6 CD cord-010092-uftc8inx 12008 66 . . . cord-010092-uftc8inx 12009 1 the the DT cord-010092-uftc8inx 12009 2 number number NN cord-010092-uftc8inx 12009 3 of of IN cord-010092-uftc8inx 12009 4 colonies colony NNS cord-010092-uftc8inx 12009 5 formed form VBN cord-010092-uftc8inx 12009 6 by by IN cord-010092-uftc8inx 12009 7 hematopoietic hematopoietic JJ cord-010092-uftc8inx 12009 8 stem stem NN cord-010092-uftc8inx 12009 9 ( ( -LRB- cord-010092-uftc8inx 12009 10 progenitor progenitor NN cord-010092-uftc8inx 12009 11 ) ) -RRB- cord-010092-uftc8inx 12009 12 cells cell NNS cord-010092-uftc8inx 12009 13 in in IN cord-010092-uftc8inx 12009 14 the the DT cord-010092-uftc8inx 12009 15 anti anti JJ cord-010092-uftc8inx 12009 16 - - JJ cord-010092-uftc8inx 12009 17 CD36 cd36 JJ cord-010092-uftc8inx 12009 18 monoclonal monoclonal JJ cord-010092-uftc8inx 12009 19 antibody antibody NN cord-010092-uftc8inx 12009 20 culture culture NN cord-010092-uftc8inx 12009 21 group group NN cord-010092-uftc8inx 12009 22 was be VBD cord-010092-uftc8inx 12009 23 significantly significantly RB cord-010092-uftc8inx 12009 24 lower low JJR cord-010092-uftc8inx 12009 25 than than IN cord-010092-uftc8inx 12009 26 that that DT cord-010092-uftc8inx 12009 27 of of IN cord-010092-uftc8inx 12009 28 the the DT cord-010092-uftc8inx 12009 29 other other JJ cord-010092-uftc8inx 12009 30 groups group NNS cord-010092-uftc8inx 12009 31 ( ( -LRB- cord-010092-uftc8inx 12009 32 P p NN cord-010092-uftc8inx 12009 33 < < XX cord-010092-uftc8inx 12009 34 0.05 0.05 CD cord-010092-uftc8inx 12009 35 ) ) -RRB- cord-010092-uftc8inx 12009 36 . . . cord-010092-uftc8inx 12010 1 Summary Summary NNP cord-010092-uftc8inx 12010 2 / / SYM cord-010092-uftc8inx 12010 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 12010 4 : : : cord-010092-uftc8inx 12011 1 Anti anti JJ cord-010092-uftc8inx 12011 2 - - JJ cord-010092-uftc8inx 12011 3 CD36 CD36 NNP cord-010092-uftc8inx 12011 4 monoclonal monoclonal JJ cord-010092-uftc8inx 12011 5 antibody antibody NN cord-010092-uftc8inx 12011 6 can can MD cord-010092-uftc8inx 12011 7 reduce reduce VB cord-010092-uftc8inx 12011 8 the the DT cord-010092-uftc8inx 12011 9 proliferation proliferation NN cord-010092-uftc8inx 12011 10 of of IN cord-010092-uftc8inx 12011 11 human human JJ cord-010092-uftc8inx 12011 12 CD34 CD34 NNP cord-010092-uftc8inx 12011 13 + + CC cord-010092-uftc8inx 12011 14 hematopoietic hematopoietic JJ cord-010092-uftc8inx 12011 15 stem stem NN cord-010092-uftc8inx 12011 16 ( ( -LRB- cord-010092-uftc8inx 12011 17 progenitor progenitor NN cord-010092-uftc8inx 12011 18 ) ) -RRB- cord-010092-uftc8inx 12011 19 cells cell NNS cord-010092-uftc8inx 12011 20 and and CC cord-010092-uftc8inx 12011 21 reduce reduce VB cord-010092-uftc8inx 12011 22 the the DT cord-010092-uftc8inx 12011 23 ability ability NN cord-010092-uftc8inx 12011 24 of of IN cord-010092-uftc8inx 12011 25 erythroid erythroid JJ cord-010092-uftc8inx 12011 26 differentiation differentiation NN cord-010092-uftc8inx 12011 27 . . . cord-010092-uftc8inx 12012 1 Background background NN cord-010092-uftc8inx 12012 2 : : : cord-010092-uftc8inx 12013 1 Recently recently RB cord-010092-uftc8inx 12013 2 the the DT cord-010092-uftc8inx 12013 3 new new JJ cord-010092-uftc8inx 12013 4 modern modern JJ cord-010092-uftc8inx 12013 5 collection collection NN cord-010092-uftc8inx 12013 6 techniques technique NNS cord-010092-uftc8inx 12013 7 were be VBD cord-010092-uftc8inx 12013 8 introduced introduce VBN cord-010092-uftc8inx 12013 9 in in IN cord-010092-uftc8inx 12013 10 the the DT cord-010092-uftc8inx 12013 11 apheresis apheresis NN cord-010092-uftc8inx 12013 12 procedures procedure NNS cord-010092-uftc8inx 12013 13 . . . cord-010092-uftc8inx 12014 1 Cobe Cobe NNP cord-010092-uftc8inx 12014 2 Spectra Spectra NNP cord-010092-uftc8inx 12014 3 system system NN cord-010092-uftc8inx 12014 4 was be VBD cord-010092-uftc8inx 12014 5 replaced replace VBN cord-010092-uftc8inx 12014 6 with with IN cord-010092-uftc8inx 12014 7 Spectra Spectra NNP cord-010092-uftc8inx 12014 8 Optia Optia NNP cord-010092-uftc8inx 12014 9 , , , cord-010092-uftc8inx 12014 10 and and CC cord-010092-uftc8inx 12014 11 it -PRON- PRP cord-010092-uftc8inx 12014 12 was be VBD cord-010092-uftc8inx 12014 13 necessary necessary JJ cord-010092-uftc8inx 12014 14 to to TO cord-010092-uftc8inx 12014 15 verify verify VB cord-010092-uftc8inx 12014 16 the the DT cord-010092-uftc8inx 12014 17 efficiency efficiency NN cord-010092-uftc8inx 12014 18 of of IN cord-010092-uftc8inx 12014 19 Spectra Spectra NNP cord-010092-uftc8inx 12014 20 Optia Optia NNP cord-010092-uftc8inx 12014 21 in in IN cord-010092-uftc8inx 12014 22 PBPC PBPC NNP cord-010092-uftc8inx 12014 23 collections collection NNS cord-010092-uftc8inx 12014 24 . . . cord-010092-uftc8inx 12015 1 Aims aim VBZ cord-010092-uftc8inx 12015 2 : : : cord-010092-uftc8inx 12016 1 The the DT cord-010092-uftc8inx 12016 2 aim aim NN cord-010092-uftc8inx 12016 3 of of IN cord-010092-uftc8inx 12016 4 the the DT cord-010092-uftc8inx 12016 5 study study NN cord-010092-uftc8inx 12016 6 was be VBD cord-010092-uftc8inx 12016 7 to to TO cord-010092-uftc8inx 12016 8 evaluate evaluate VB cord-010092-uftc8inx 12016 9 and and CC cord-010092-uftc8inx 12016 10 optimize optimize VB cord-010092-uftc8inx 12016 11 the the DT cord-010092-uftc8inx 12016 12 new new JJ cord-010092-uftc8inx 12016 13 CMNC CMNC NNP cord-010092-uftc8inx 12016 14 protocol protocol NN cord-010092-uftc8inx 12016 15 Spectra Spectra NNP cord-010092-uftc8inx 12016 16 Optia Optia NNP cord-010092-uftc8inx 12016 17 v. v. IN cord-010092-uftc8inx 12016 18 11 11 CD cord-010092-uftc8inx 12017 1 ( ( -LRB- cord-010092-uftc8inx 12017 2 Terumo Terumo NNP cord-010092-uftc8inx 12017 3 ) ) -RRB- cord-010092-uftc8inx 12017 4 for for IN cord-010092-uftc8inx 12017 5 PBPC PBPC NNP cord-010092-uftc8inx 12017 6 collections collection NNS cord-010092-uftc8inx 12017 7 in in IN cord-010092-uftc8inx 12017 8 patients patient NNS cord-010092-uftc8inx 12017 9 with with IN cord-010092-uftc8inx 12017 10 haemato haemato JJ cord-010092-uftc8inx 12017 11 - - HYPH cord-010092-uftc8inx 12017 12 oncological oncological JJ cord-010092-uftc8inx 12017 13 malignant malignant JJ cord-010092-uftc8inx 12017 14 diseases disease NNS cord-010092-uftc8inx 12017 15 . . . cord-010092-uftc8inx 12018 1 Methods method NNS cord-010092-uftc8inx 12018 2 : : : cord-010092-uftc8inx 12019 1 The the DT cord-010092-uftc8inx 12019 2 results result NNS cord-010092-uftc8inx 12019 3 of of IN cord-010092-uftc8inx 12019 4 159 159 CD cord-010092-uftc8inx 12019 5 autologous autologous JJ cord-010092-uftc8inx 12019 6 PBPC PBPC NNP cord-010092-uftc8inx 12019 7 collections collection NNS cord-010092-uftc8inx 12019 8 were be VBD cord-010092-uftc8inx 12019 9 evaluated evaluate VBN cord-010092-uftc8inx 12019 10 in in IN cord-010092-uftc8inx 12019 11 : : : cord-010092-uftc8inx 12019 12 ( ( -LRB- cord-010092-uftc8inx 12019 13 a a LS cord-010092-uftc8inx 12019 14 ) ) -RRB- cord-010092-uftc8inx 12019 15 well well RB cord-010092-uftc8inx 12019 16 mobilized mobilize VBD cord-010092-uftc8inx 12019 17 patients patient NNS cord-010092-uftc8inx 12019 18 with with IN cord-010092-uftc8inx 12019 19 precollection precollection NN cord-010092-uftc8inx 12019 20 CD CD NNP cord-010092-uftc8inx 12019 21 34 34 CD cord-010092-uftc8inx 12019 22 + + SYM cord-010092-uftc8inx 12019 23 cells cell NNS cord-010092-uftc8inx 12019 24 concentration concentration NN cord-010092-uftc8inx 12019 25 in in IN cord-010092-uftc8inx 12019 26 blood blood NN cord-010092-uftc8inx 12019 27 higher high JJR cord-010092-uftc8inx 12019 28 than than IN cord-010092-uftc8inx 12019 29 20 20 CD cord-010092-uftc8inx 12020 1 /ll /ll NFP cord-010092-uftc8inx 12020 2 , , , cord-010092-uftc8inx 12020 3 ( ( -LRB- cord-010092-uftc8inx 12020 4 b b NN cord-010092-uftc8inx 12020 5 ) ) -RRB- cord-010092-uftc8inx 12020 6 from from IN cord-010092-uftc8inx 12020 7 only only RB cord-010092-uftc8inx 12020 8 the the DT cord-010092-uftc8inx 12020 9 first first JJ cord-010092-uftc8inx 12020 10 collections collection NNS cord-010092-uftc8inx 12020 11 , , , cord-010092-uftc8inx 12020 12 which which WDT cord-010092-uftc8inx 12020 13 were be VBD cord-010092-uftc8inx 12020 14 performed perform VBN cord-010092-uftc8inx 12020 15 either either CC cord-010092-uftc8inx 12020 16 by by IN cord-010092-uftc8inx 12020 17 the the DT cord-010092-uftc8inx 12020 18 use use NN cord-010092-uftc8inx 12020 19 CMNC CMNC NNP cord-010092-uftc8inx 12020 20 Spectra Spectra NNP cord-010092-uftc8inx 12020 21 Optia Optia NNP cord-010092-uftc8inx 12020 22 v. v. CC cord-010092-uftc8inx 12020 23 11 11 CD cord-010092-uftc8inx 12020 24 or or CC cord-010092-uftc8inx 12020 25 Cobe Cobe NNP cord-010092-uftc8inx 12020 26 Spectra Spectra NNP cord-010092-uftc8inx 12020 27 v. v. NNP cord-010092-uftc8inx 12020 28 6 6 CD cord-010092-uftc8inx 12020 29 , , , cord-010092-uftc8inx 12020 30 v. v. IN cord-010092-uftc8inx 12020 31 7 7 CD cord-010092-uftc8inx 12021 1 , , , cord-010092-uftc8inx 12021 2 Terumo Terumo NNP cord-010092-uftc8inx 12021 3 ( ( -LRB- cord-010092-uftc8inx 12021 4 c c NN cord-010092-uftc8inx 12021 5 ) ) -RRB- cord-010092-uftc8inx 12021 6 Collections collection NNS cord-010092-uftc8inx 12021 7 were be VBD cord-010092-uftc8inx 12021 8 performed perform VBN cord-010092-uftc8inx 12021 9 in in IN cord-010092-uftc8inx 12021 10 the the DT cord-010092-uftc8inx 12021 11 Standard Standard NNP cord-010092-uftc8inx 12021 12 and and CC cord-010092-uftc8inx 12021 13 Large large JJ cord-010092-uftc8inx 12021 14 volume volume NN cord-010092-uftc8inx 12021 15 Leukapheresis Leukapheresis NNP cord-010092-uftc8inx 12021 16 regimen regimen NN cord-010092-uftc8inx 12021 17 , , , cord-010092-uftc8inx 12021 18 LVL LVL NNP cord-010092-uftc8inx 12021 19 . . . cord-010092-uftc8inx 12022 1 Engraftment Engraftment NNP cord-010092-uftc8inx 12022 2 data datum NNS cord-010092-uftc8inx 12022 3 in in IN cord-010092-uftc8inx 12022 4 56 56 CD cord-010092-uftc8inx 12022 5 transplanted transplant VBN cord-010092-uftc8inx 12022 6 patients patient NNS cord-010092-uftc8inx 12022 7 were be VBD cord-010092-uftc8inx 12022 8 assessed assess VBN cord-010092-uftc8inx 12022 9 . . . cord-010092-uftc8inx 12023 1 Results result NNS cord-010092-uftc8inx 12023 2 : : : cord-010092-uftc8inx 12024 1 Standard standard JJ cord-010092-uftc8inx 12024 2 collections collection NNS cord-010092-uftc8inx 12024 3 were be VBD cord-010092-uftc8inx 12024 4 performed perform VBN cord-010092-uftc8inx 12024 5 in in IN cord-010092-uftc8inx 12024 6 52 52 CD cord-010092-uftc8inx 12024 7 patients patient NNS cord-010092-uftc8inx 12024 8 . . . cord-010092-uftc8inx 12025 1 The the DT cord-010092-uftc8inx 12025 2 yield yield NN cord-010092-uftc8inx 12025 3 of of IN cord-010092-uftc8inx 12025 4 CD CD NNP cord-010092-uftc8inx 12025 5 34 34 CD cord-010092-uftc8inx 12025 6 + + CC cord-010092-uftc8inx 12025 7 cells cell NNS cord-010092-uftc8inx 12025 8 was be VBD cord-010092-uftc8inx 12025 9 high high JJ cord-010092-uftc8inx 12025 10 , , , cord-010092-uftc8inx 12025 11 and and CC cord-010092-uftc8inx 12025 12 no no DT cord-010092-uftc8inx 12025 13 significant significant JJ cord-010092-uftc8inx 12025 14 differences difference NNS cord-010092-uftc8inx 12025 15 were be VBD cord-010092-uftc8inx 12025 16 found find VBN cord-010092-uftc8inx 12025 17 between between IN cord-010092-uftc8inx 12025 18 the the DT cord-010092-uftc8inx 12025 19 numbers number NNS cord-010092-uftc8inx 12025 20 of of IN cord-010092-uftc8inx 12025 21 CD CD NNP cord-010092-uftc8inx 12025 22 34 34 CD cord-010092-uftc8inx 12025 23 + + SYM cord-010092-uftc8inx 12025 24 cells cell NNS cord-010092-uftc8inx 12025 25 prepared prepare VBN cord-010092-uftc8inx 12025 26 from from IN cord-010092-uftc8inx 12025 27 Spectra Spectra NNP cord-010092-uftc8inx 12025 28 Optia Optia NNP cord-010092-uftc8inx 12025 29 8,6 8,6 CD cord-010092-uftc8inx 12025 30 ( ( -LRB- cord-010092-uftc8inx 12025 31 1,3 1,3 CD cord-010092-uftc8inx 12025 32 - - SYM cord-010092-uftc8inx 12025 33 41 41 CD cord-010092-uftc8inx 12025 34 ) ) -RRB- cord-010092-uftc8inx 12025 35 9 9 CD cord-010092-uftc8inx 12025 36 10 10 CD cord-010092-uftc8inx 12025 37 6 6 CD cord-010092-uftc8inx 12025 38 and and CC cord-010092-uftc8inx 12025 39 Cobe Cobe NNP cord-010092-uftc8inx 12025 40 Spectra Spectra NNP cord-010092-uftc8inx 12025 41 10,9 10,9 CD cord-010092-uftc8inx 12025 42 ( ( -LRB- cord-010092-uftc8inx 12025 43 1 1 CD cord-010092-uftc8inx 12025 44 , , , cord-010092-uftc8inx 12025 45 6 6 CD cord-010092-uftc8inx 12025 46 ) ) -RRB- cord-010092-uftc8inx 12026 1 9 9 CD cord-010092-uftc8inx 12026 2 10 10 CD cord-010092-uftc8inx 12026 3 6 6 CD cord-010092-uftc8inx 12026 4 /kg /kg . cord-010092-uftc8inx 12026 5 b. b. NNP cord-010092-uftc8inx 12026 6 w. w. NNP cord-010092-uftc8inx 12026 7 ( ( -LRB- cord-010092-uftc8inx 12026 8 a a NN cord-010092-uftc8inx 12026 9 = = SYM cord-010092-uftc8inx 12026 10 0,05 0,05 XX cord-010092-uftc8inx 12026 11 ; ; . cord-010092-uftc8inx 12027 1 pval pval NNP cord-010092-uftc8inx 12027 2 0,619 0,619 CD cord-010092-uftc8inx 12027 3 ) ) -RRB- cord-010092-uftc8inx 12027 4 . . . cord-010092-uftc8inx 12028 1 The the DT cord-010092-uftc8inx 12028 2 dependence dependence NN cord-010092-uftc8inx 12028 3 of of IN cord-010092-uftc8inx 12028 4 CD CD NNP cord-010092-uftc8inx 12028 5 34 34 CD cord-010092-uftc8inx 12028 6 + + CD cord-010092-uftc8inx 12028 7 cell cell NN cord-010092-uftc8inx 12028 8 yield yield NN cord-010092-uftc8inx 12028 9 on on IN cord-010092-uftc8inx 12028 10 the the DT cord-010092-uftc8inx 12028 11 precollection precollection NN cord-010092-uftc8inx 12028 12 concentration concentration NN cord-010092-uftc8inx 12028 13 of of IN cord-010092-uftc8inx 12028 14 CD CD NNP cord-010092-uftc8inx 12028 15 34 34 CD cord-010092-uftc8inx 12028 16 + + SYM cord-010092-uftc8inx 12028 17 cells cell NNS cord-010092-uftc8inx 12028 18 in in IN cord-010092-uftc8inx 12028 19 blood blood NN cord-010092-uftc8inx 12028 20 can can MD cord-010092-uftc8inx 12028 21 be be VB cord-010092-uftc8inx 12028 22 considered consider VBN cord-010092-uftc8inx 12028 23 as as RB cord-010092-uftc8inx 12028 24 linear linear JJ cord-010092-uftc8inx 12028 25 with with IN cord-010092-uftc8inx 12028 26 high high JJ cord-010092-uftc8inx 12028 27 correlation correlation NN cord-010092-uftc8inx 12028 28 coefficients coefficient NNS cord-010092-uftc8inx 12028 29 in in IN cord-010092-uftc8inx 12028 30 CMNC CMNC NNP cord-010092-uftc8inx 12028 31 Spectra Spectra NNP cord-010092-uftc8inx 12028 32 Optia Optia NNP cord-010092-uftc8inx 12028 33 R R NNP cord-010092-uftc8inx 12028 34 = = SYM cord-010092-uftc8inx 12028 35 0,95 0,95 NN cord-010092-uftc8inx 12028 36 , , , cord-010092-uftc8inx 12028 37 and and CC cord-010092-uftc8inx 12028 38 Cobe Cobe NNP cord-010092-uftc8inx 12028 39 Spectra Spectra NNP cord-010092-uftc8inx 12028 40 R r NN cord-010092-uftc8inx 12028 41 = = SYM cord-010092-uftc8inx 12028 42 0,93 0,93 NN cord-010092-uftc8inx 12028 43 . . . cord-010092-uftc8inx 12029 1 LVL LVL NNP cord-010092-uftc8inx 12029 2 collections collection NNS cord-010092-uftc8inx 12029 3 were be VBD cord-010092-uftc8inx 12029 4 performed perform VBN cord-010092-uftc8inx 12029 5 in in IN cord-010092-uftc8inx 12029 6 107 107 CD cord-010092-uftc8inx 12029 7 of of IN cord-010092-uftc8inx 12029 8 patients patient NNS cord-010092-uftc8inx 12029 9 , , , cord-010092-uftc8inx 12029 10 and and CC cord-010092-uftc8inx 12029 11 there there EX cord-010092-uftc8inx 12029 12 were be VBD cord-010092-uftc8inx 12029 13 no no DT cord-010092-uftc8inx 12029 14 significant significant JJ cord-010092-uftc8inx 12029 15 differences difference NNS cord-010092-uftc8inx 12029 16 between between IN cord-010092-uftc8inx 12029 17 the the DT cord-010092-uftc8inx 12029 18 numbers number NNS cord-010092-uftc8inx 12029 19 of of IN cord-010092-uftc8inx 12029 20 CD CD NNP cord-010092-uftc8inx 12029 21 34 34 CD cord-010092-uftc8inx 12029 22 + + SYM cord-010092-uftc8inx 12029 23 cells cell NNS cord-010092-uftc8inx 12029 24 prepared prepare VBN cord-010092-uftc8inx 12029 25 by by IN cord-010092-uftc8inx 12029 26 CMNC CMNC NNP cord-010092-uftc8inx 12029 27 Spectra Spectra NNP cord-010092-uftc8inx 12029 28 Optia Optia NNP cord-010092-uftc8inx 12029 29 10,9 10,9 CD cord-010092-uftc8inx 12029 30 ( ( -LRB- cord-010092-uftc8inx 12029 31 2 2 CD cord-010092-uftc8inx 12029 32 - - SYM cord-010092-uftc8inx 12029 33 61,2)9 61,2)9 CD cord-010092-uftc8inx 12029 34 10 10 CD cord-010092-uftc8inx 12029 35 6 6 CD cord-010092-uftc8inx 12029 36 and and CC cord-010092-uftc8inx 12029 37 Cobe Cobe NNP cord-010092-uftc8inx 12029 38 Spectra Spectra NNP cord-010092-uftc8inx 12029 39 9,3 9,3 CD cord-010092-uftc8inx 12029 40 ( ( -LRB- cord-010092-uftc8inx 12029 41 2,4 2,4 CD cord-010092-uftc8inx 12029 42 - - SYM cord-010092-uftc8inx 12029 43 86 86 CD cord-010092-uftc8inx 12029 44 ) ) -RRB- cord-010092-uftc8inx 12029 45 9 9 CD cord-010092-uftc8inx 12029 46 10 10 CD cord-010092-uftc8inx 12029 47 6 6 CD cord-010092-uftc8inx 12030 1 /kg /kg . cord-010092-uftc8inx 12031 1 b.w b.w NNP cord-010092-uftc8inx 12031 2 . . . cord-010092-uftc8inx 12032 1 ( ( -LRB- cord-010092-uftc8inx 12032 2 a a DT cord-010092-uftc8inx 12032 3 = = SYM cord-010092-uftc8inx 12032 4 0,05 0,05 NN cord-010092-uftc8inx 12032 5 ; ; : cord-010092-uftc8inx 12032 6 pval pval NNP cord-010092-uftc8inx 12032 7 0,35 0,35 NNP cord-010092-uftc8inx 12032 8 ) ) -RRB- cord-010092-uftc8inx 12032 9 . . . cord-010092-uftc8inx 12033 1 The the DT cord-010092-uftc8inx 12033 2 relations relation NNS cord-010092-uftc8inx 12033 3 between between IN cord-010092-uftc8inx 12033 4 the the DT cord-010092-uftc8inx 12033 5 precollection precollection NN cord-010092-uftc8inx 12033 6 CD CD NNP cord-010092-uftc8inx 12033 7 34 34 CD cord-010092-uftc8inx 12033 8 + + SYM cord-010092-uftc8inx 12033 9 cells cell NNS cord-010092-uftc8inx 12033 10 concentration concentration NN cord-010092-uftc8inx 12033 11 in in IN cord-010092-uftc8inx 12033 12 blood blood NN cord-010092-uftc8inx 12033 13 and and CC cord-010092-uftc8inx 12033 14 the the DT cord-010092-uftc8inx 12033 15 numbers number NNS cord-010092-uftc8inx 12033 16 of of IN cord-010092-uftc8inx 12033 17 CD CD NNP cord-010092-uftc8inx 12033 18 34 34 CD cord-010092-uftc8inx 12033 19 + + SYM cord-010092-uftc8inx 12033 20 cells cell NNS cord-010092-uftc8inx 12033 21 from from IN cord-010092-uftc8inx 12033 22 collections collection NNS cord-010092-uftc8inx 12033 23 can can MD cord-010092-uftc8inx 12033 24 also also RB cord-010092-uftc8inx 12033 25 be be VB cord-010092-uftc8inx 12033 26 considered consider VBN cord-010092-uftc8inx 12033 27 as as RB cord-010092-uftc8inx 12033 28 linear linear JJ cord-010092-uftc8inx 12033 29 with with IN cord-010092-uftc8inx 12033 30 the the DT cord-010092-uftc8inx 12033 31 correlation correlation NN cord-010092-uftc8inx 12033 32 coefficients coefficient NNS cord-010092-uftc8inx 12033 33 in in IN cord-010092-uftc8inx 12033 34 CMNC CMNC NNP cord-010092-uftc8inx 12034 1 Spectra Spectra NNP cord-010092-uftc8inx 12034 2 Optia Optia NNP cord-010092-uftc8inx 12034 3 R R NNP cord-010092-uftc8inx 12034 4 = = SYM cord-010092-uftc8inx 12034 5 0,93 0,93 NN cord-010092-uftc8inx 12034 6 , , , cord-010092-uftc8inx 12034 7 and and CC cord-010092-uftc8inx 12034 8 Cobe Cobe NNP cord-010092-uftc8inx 12034 9 Spectra Spectra NNP cord-010092-uftc8inx 12034 10 R R NNP cord-010092-uftc8inx 12034 11 = = SYM cord-010092-uftc8inx 12034 12 0,78 0,78 NNS cord-010092-uftc8inx 12034 13 , , , cord-010092-uftc8inx 12034 14 respectively respectively RB cord-010092-uftc8inx 12034 15 . . . cord-010092-uftc8inx 12035 1 In in IN cord-010092-uftc8inx 12035 2 LVL LVL NNP cord-010092-uftc8inx 12035 3 , , , cord-010092-uftc8inx 12035 4 the the DT cord-010092-uftc8inx 12035 5 median median JJ cord-010092-uftc8inx 12035 6 platelet platelet NN cord-010092-uftc8inx 12035 7 loss loss NN cord-010092-uftc8inx 12035 8 was be VBD cord-010092-uftc8inx 12035 9 significantly significantly RB cord-010092-uftc8inx 12035 10 lower low JJR cord-010092-uftc8inx 12035 11 in in IN cord-010092-uftc8inx 12035 12 CMNC CMNC NNP cord-010092-uftc8inx 12035 13 Spectra Spectra NNP cord-010092-uftc8inx 12035 14 Optia Optia NNP cord-010092-uftc8inx 12035 15 ( ( -LRB- cord-010092-uftc8inx 12035 16 45 45 CD cord-010092-uftc8inx 12035 17 % % NN cord-010092-uftc8inx 12035 18 ) ) -RRB- cord-010092-uftc8inx 12035 19 than than IN cord-010092-uftc8inx 12035 20 in in IN cord-010092-uftc8inx 12035 21 Cobe Cobe NNP cord-010092-uftc8inx 12035 22 Spectra Spectra NNP cord-010092-uftc8inx 12035 23 ( ( -LRB- cord-010092-uftc8inx 12035 24 57 57 CD cord-010092-uftc8inx 12035 25 % % NN cord-010092-uftc8inx 12035 26 ) ) -RRB- cord-010092-uftc8inx 12035 27 . . . cord-010092-uftc8inx 12036 1 A a DT cord-010092-uftc8inx 12036 2 group group NN cord-010092-uftc8inx 12036 3 of of IN cord-010092-uftc8inx 12036 4 12 12 CD cord-010092-uftc8inx 12036 5 patients patient NNS cord-010092-uftc8inx 12036 6 was be VBD cord-010092-uftc8inx 12036 7 transplanted transplant VBN cord-010092-uftc8inx 12036 8 by by IN cord-010092-uftc8inx 12036 9 means mean NNS cord-010092-uftc8inx 12036 10 of of IN cord-010092-uftc8inx 12036 11 PBPC PBPC NNP cord-010092-uftc8inx 12036 12 prepared prepare VBN cord-010092-uftc8inx 12036 13 in in IN cord-010092-uftc8inx 12036 14 the the DT cord-010092-uftc8inx 12036 15 standard standard JJ cord-010092-uftc8inx 12036 16 regimen regimen NN cord-010092-uftc8inx 12036 17 . . . cord-010092-uftc8inx 12037 1 Median median JJ cord-010092-uftc8inx 12037 2 time time NN cord-010092-uftc8inx 12037 3 in in IN cord-010092-uftc8inx 12037 4 the the DT cord-010092-uftc8inx 12037 5 neutrophil neutrophil NN cord-010092-uftc8inx 12037 6 reconstitution reconstitution NN cord-010092-uftc8inx 12037 7 was be VBD cord-010092-uftc8inx 12037 8 in in IN cord-010092-uftc8inx 12037 9 CMNC CMNC NNP cord-010092-uftc8inx 12037 10 Spectra Spectra NNP cord-010092-uftc8inx 12037 11 Optia Optia NNP cord-010092-uftc8inx 12037 12 as as RB cord-010092-uftc8inx 12037 13 well well RB cord-010092-uftc8inx 12037 14 as as IN cord-010092-uftc8inx 12037 15 Cobe Cobe NNP cord-010092-uftc8inx 12037 16 Spectra Spectra NNP cord-010092-uftc8inx 12037 17 11 11 CD cord-010092-uftc8inx 12037 18 days day NNS cord-010092-uftc8inx 12037 19 , , , cord-010092-uftc8inx 12037 20 while while IN cord-010092-uftc8inx 12037 21 in in IN cord-010092-uftc8inx 12037 22 platelets platelet NNS cord-010092-uftc8inx 12037 23 from from IN cord-010092-uftc8inx 12037 24 CMNC CMNC NNP cord-010092-uftc8inx 12037 25 14 14 CD cord-010092-uftc8inx 12037 26 days day NNS cord-010092-uftc8inx 12037 27 , , , cord-010092-uftc8inx 12037 28 and and CC cord-010092-uftc8inx 12037 29 from from IN cord-010092-uftc8inx 12037 30 Cobe Cobe NNP cord-010092-uftc8inx 12037 31 Spectra Spectra NNP cord-010092-uftc8inx 12037 32 12 12 CD cord-010092-uftc8inx 12037 33 days day NNS cord-010092-uftc8inx 12037 34 , , , cord-010092-uftc8inx 12037 35 respectively respectively RB cord-010092-uftc8inx 12037 36 . . . cord-010092-uftc8inx 12038 1 The the DT cord-010092-uftc8inx 12038 2 number number NN cord-010092-uftc8inx 12038 3 of of IN cord-010092-uftc8inx 12038 4 44 44 CD cord-010092-uftc8inx 12038 5 patients patient NNS cord-010092-uftc8inx 12038 6 obtained obtain VBD cord-010092-uftc8inx 12038 7 PBPC PBPC NNP cord-010092-uftc8inx 12038 8 from from IN cord-010092-uftc8inx 12038 9 LVL LVL NNP cord-010092-uftc8inx 12038 10 . . . cord-010092-uftc8inx 12039 1 The the DT cord-010092-uftc8inx 12039 2 median median JJ cord-010092-uftc8inx 12039 3 time time NN cord-010092-uftc8inx 12039 4 in in IN cord-010092-uftc8inx 12039 5 neutrophils neutrophil NNS cord-010092-uftc8inx 12039 6 and and CC cord-010092-uftc8inx 12039 7 platelets platelet NNS cord-010092-uftc8inx 12039 8 reconstitution reconstitution NN cord-010092-uftc8inx 12039 9 was be VBD cord-010092-uftc8inx 12039 10 in in IN cord-010092-uftc8inx 12039 11 CMNC CMNC NNP cord-010092-uftc8inx 12039 12 Spectra Spectra NNP cord-010092-uftc8inx 12039 13 Optia Optia NNP cord-010092-uftc8inx 12039 14 as as RB cord-010092-uftc8inx 12039 15 well well RB cord-010092-uftc8inx 12039 16 as as IN cord-010092-uftc8inx 12039 17 Cobe Cobe NNP cord-010092-uftc8inx 12039 18 Spectra Spectra NNP cord-010092-uftc8inx 12039 19 the the DT cord-010092-uftc8inx 12039 20 same same JJ cord-010092-uftc8inx 12039 21 , , , cord-010092-uftc8inx 12039 22 and and CC cord-010092-uftc8inx 12039 23 corresponded correspond VBD cord-010092-uftc8inx 12039 24 with with IN cord-010092-uftc8inx 12039 25 11 11 CD cord-010092-uftc8inx 12039 26 and and CC cord-010092-uftc8inx 12039 27 13 13 CD cord-010092-uftc8inx 12039 28 days day NNS cord-010092-uftc8inx 12039 29 , , , cord-010092-uftc8inx 12039 30 respectively respectively RB cord-010092-uftc8inx 12039 31 . . . cord-010092-uftc8inx 12040 1 Summary Summary NNP cord-010092-uftc8inx 12040 2 / / SYM cord-010092-uftc8inx 12040 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 12040 4 : : : cord-010092-uftc8inx 12041 1 CMNC CMNC NNP cord-010092-uftc8inx 12041 2 protocol protocol NN cord-010092-uftc8inx 12041 3 Spectra Spectra NNP cord-010092-uftc8inx 12041 4 Optia Optia NNP cord-010092-uftc8inx 12041 5 is be VBZ cord-010092-uftc8inx 12041 6 a a DT cord-010092-uftc8inx 12041 7 modern modern JJ cord-010092-uftc8inx 12041 8 , , , cord-010092-uftc8inx 12041 9 efficient efficient JJ cord-010092-uftc8inx 12041 10 and and CC cord-010092-uftc8inx 12041 11 the the DT cord-010092-uftc8inx 12041 12 safe safe JJ cord-010092-uftc8inx 12041 13 system system NN cord-010092-uftc8inx 12041 14 , , , cord-010092-uftc8inx 12041 15 which which WDT cord-010092-uftc8inx 12041 16 can can MD cord-010092-uftc8inx 12041 17 be be VB cord-010092-uftc8inx 12041 18 used use VBN cord-010092-uftc8inx 12041 19 for for IN cord-010092-uftc8inx 12041 20 both both DT cord-010092-uftc8inx 12041 21 Standard Standard NNP cord-010092-uftc8inx 12041 22 and and CC cord-010092-uftc8inx 12041 23 LVL LVL NNP cord-010092-uftc8inx 12041 24 procedures procedure NNS cord-010092-uftc8inx 12041 25 . . . cord-010092-uftc8inx 12042 1 In in IN cord-010092-uftc8inx 12042 2 well well RB cord-010092-uftc8inx 12042 3 mobilized mobilize VBN cord-010092-uftc8inx 12042 4 patients patient NNS cord-010092-uftc8inx 12042 5 the the DT cord-010092-uftc8inx 12042 6 sufficient sufficient JJ cord-010092-uftc8inx 12042 7 dose dose NN cord-010092-uftc8inx 12042 8 of of IN cord-010092-uftc8inx 12042 9 CD CD NNP cord-010092-uftc8inx 12042 10 34 34 CD cord-010092-uftc8inx 12042 11 + + CC cord-010092-uftc8inx 12042 12 cells cell NNS cord-010092-uftc8inx 12042 13 for for IN cord-010092-uftc8inx 12042 14 transplantation transplantation NN cord-010092-uftc8inx 12042 15 could could MD cord-010092-uftc8inx 12042 16 be be VB cord-010092-uftc8inx 12042 17 prepared prepare VBN cord-010092-uftc8inx 12042 18 from from IN cord-010092-uftc8inx 12042 19 one one CD cord-010092-uftc8inx 12042 20 Standard Standard NNP cord-010092-uftc8inx 12042 21 or or CC cord-010092-uftc8inx 12042 22 one one CD cord-010092-uftc8inx 12042 23 LVL LVL NNP cord-010092-uftc8inx 12042 24 procedure procedure NN cord-010092-uftc8inx 12042 25 . . . cord-010092-uftc8inx 12043 1 No no DT cord-010092-uftc8inx 12043 2 serious serious JJ cord-010092-uftc8inx 12043 3 adverse adverse JJ cord-010092-uftc8inx 12043 4 reaction reaction NN cord-010092-uftc8inx 12043 5 have have VBP cord-010092-uftc8inx 12043 6 been be VBN cord-010092-uftc8inx 12043 7 observed observe VBN cord-010092-uftc8inx 12043 8 . . . cord-010092-uftc8inx 12044 1 Background background NN cord-010092-uftc8inx 12044 2 : : : cord-010092-uftc8inx 12045 1 Peripheral peripheral JJ cord-010092-uftc8inx 12045 2 hematopoietic hematopoietic JJ cord-010092-uftc8inx 12045 3 stem stem NN cord-010092-uftc8inx 12045 4 cells cell NNS cord-010092-uftc8inx 12045 5 are be VBP cord-010092-uftc8inx 12045 6 collected collect VBN cord-010092-uftc8inx 12045 7 from from IN cord-010092-uftc8inx 12045 8 patients patient NNS cord-010092-uftc8inx 12045 9 / / SYM cord-010092-uftc8inx 12045 10 donors donor NNS cord-010092-uftc8inx 12045 11 after after IN cord-010092-uftc8inx 12045 12 mobilization mobilization NN cord-010092-uftc8inx 12045 13 with with IN cord-010092-uftc8inx 12045 14 G G NNP cord-010092-uftc8inx 12045 15 - - HYPH cord-010092-uftc8inx 12045 16 SCF SCF NNP cord-010092-uftc8inx 12045 17 . . . cord-010092-uftc8inx 12046 1 The the DT cord-010092-uftc8inx 12046 2 aim aim NN cord-010092-uftc8inx 12046 3 of of IN cord-010092-uftc8inx 12046 4 the the DT cord-010092-uftc8inx 12046 5 collection collection NN cord-010092-uftc8inx 12046 6 is be VBZ cord-010092-uftc8inx 12046 7 a a DT cord-010092-uftc8inx 12046 8 fixed fix VBN cord-010092-uftc8inx 12046 9 number number NN cord-010092-uftc8inx 12046 10 of of IN cord-010092-uftc8inx 12046 11 CD34 CD34 NNP cord-010092-uftc8inx 12046 12 + + CC cord-010092-uftc8inx 12046 13 cells cell NNS cord-010092-uftc8inx 12046 14 / / SYM cord-010092-uftc8inx 12046 15 kg kg NNS cord-010092-uftc8inx 12046 16 . . . cord-010092-uftc8inx 12047 1 This this DT cord-010092-uftc8inx 12047 2 number number NN cord-010092-uftc8inx 12047 3 depends depend VBZ cord-010092-uftc8inx 12047 4 on on IN cord-010092-uftc8inx 12047 5 the the DT cord-010092-uftc8inx 12047 6 pre pre JJ cord-010092-uftc8inx 12047 7 - - JJ cord-010092-uftc8inx 12047 8 apheresis apheresis NN cord-010092-uftc8inx 12047 9 CD34 CD34 NNP cord-010092-uftc8inx 12047 10 + + CC cord-010092-uftc8inx 12047 11 number number NN cord-010092-uftc8inx 12047 12 , , , cord-010092-uftc8inx 12047 13 the the DT cord-010092-uftc8inx 12047 14 blood blood NN cord-010092-uftc8inx 12047 15 processed process VBN cord-010092-uftc8inx 12047 16 and and CC cord-010092-uftc8inx 12047 17 the the DT cord-010092-uftc8inx 12047 18 collection collection NN cord-010092-uftc8inx 12047 19 efficiency efficiency NN cord-010092-uftc8inx 12047 20 of of IN cord-010092-uftc8inx 12047 21 the the DT cord-010092-uftc8inx 12047 22 procedure procedure NN cord-010092-uftc8inx 12047 23 . . . cord-010092-uftc8inx 12048 1 The the DT cord-010092-uftc8inx 12048 2 aim aim NN cord-010092-uftc8inx 12048 3 should should MD cord-010092-uftc8inx 12048 4 be be VB cord-010092-uftc8inx 12048 5 to to TO cord-010092-uftc8inx 12048 6 collect collect VB cord-010092-uftc8inx 12048 7 all all PDT cord-010092-uftc8inx 12048 8 the the DT cord-010092-uftc8inx 12048 9 requested request VBN cord-010092-uftc8inx 12048 10 cells cell NNS cord-010092-uftc8inx 12048 11 in in IN cord-010092-uftc8inx 12048 12 1 1 CD cord-010092-uftc8inx 12048 13 day day NN cord-010092-uftc8inx 12048 14 , , , cord-010092-uftc8inx 12048 15 whenever whenever WRB cord-010092-uftc8inx 12048 16 possible possible JJ cord-010092-uftc8inx 12048 17 . . . cord-010092-uftc8inx 12049 1 This this DT cord-010092-uftc8inx 12049 2 is be VBZ cord-010092-uftc8inx 12049 3 in in IN cord-010092-uftc8inx 12049 4 order order NN cord-010092-uftc8inx 12049 5 to to TO cord-010092-uftc8inx 12049 6 reduce reduce VB cord-010092-uftc8inx 12049 7 the the DT cord-010092-uftc8inx 12049 8 dose dose NN cord-010092-uftc8inx 12049 9 of of IN cord-010092-uftc8inx 12049 10 G G NNP cord-010092-uftc8inx 12049 11 - - HYPH cord-010092-uftc8inx 12049 12 CSF CSF NNP cord-010092-uftc8inx 12049 13 given give VBN cord-010092-uftc8inx 12049 14 to to IN cord-010092-uftc8inx 12049 15 donor donor NN cord-010092-uftc8inx 12049 16 / / SYM cord-010092-uftc8inx 12049 17 patient patient NN cord-010092-uftc8inx 12049 18 and and CC cord-010092-uftc8inx 12049 19 the the DT cord-010092-uftc8inx 12049 20 resources resource NNS cord-010092-uftc8inx 12049 21 used use VBN cord-010092-uftc8inx 12049 22 in in IN cord-010092-uftc8inx 12049 23 the the DT cord-010092-uftc8inx 12049 24 collection collection NN cord-010092-uftc8inx 12049 25 centre centre NN cord-010092-uftc8inx 12049 26 . . . cord-010092-uftc8inx 12050 1 The the DT cord-010092-uftc8inx 12050 2 only only JJ cord-010092-uftc8inx 12050 3 parameter parameter NN cord-010092-uftc8inx 12050 4 that that WDT cord-010092-uftc8inx 12050 5 can can MD cord-010092-uftc8inx 12050 6 be be VB cord-010092-uftc8inx 12050 7 adjusted adjust VBN cord-010092-uftc8inx 12050 8 is be VBZ cord-010092-uftc8inx 12050 9 the the DT cord-010092-uftc8inx 12050 10 volume volume NN cord-010092-uftc8inx 12050 11 of of IN cord-010092-uftc8inx 12050 12 blood blood NN cord-010092-uftc8inx 12050 13 processed process VBN cord-010092-uftc8inx 12050 14 , , , cord-010092-uftc8inx 12050 15 If if IN cord-010092-uftc8inx 12050 16 this this DT cord-010092-uftc8inx 12050 17 is be VBZ cord-010092-uftc8inx 12050 18 increased increase VBN cord-010092-uftc8inx 12050 19 , , , cord-010092-uftc8inx 12050 20 the the DT cord-010092-uftc8inx 12050 21 likelihood likelihood NN cord-010092-uftc8inx 12050 22 of of IN cord-010092-uftc8inx 12050 23 collecting collect VBG cord-010092-uftc8inx 12050 24 the the DT cord-010092-uftc8inx 12050 25 requested request VBN cord-010092-uftc8inx 12050 26 amount amount NN cord-010092-uftc8inx 12050 27 of of IN cord-010092-uftc8inx 12050 28 cells cell NNS cord-010092-uftc8inx 12050 29 is be VBZ cord-010092-uftc8inx 12050 30 increased increase VBN cord-010092-uftc8inx 12050 31 , , , cord-010092-uftc8inx 12050 32 but but CC cord-010092-uftc8inx 12050 33 only only RB cord-010092-uftc8inx 12050 34 if if IN cord-010092-uftc8inx 12050 35 the the DT cord-010092-uftc8inx 12050 36 pre pre JJ cord-010092-uftc8inx 12050 37 - - JJ cord-010092-uftc8inx 12050 38 apheresis apheresis JJ cord-010092-uftc8inx 12050 39 CD34 CD34 NNP cord-010092-uftc8inx 12050 40 number number NN cord-010092-uftc8inx 12050 41 is be VBZ cord-010092-uftc8inx 12050 42 high high JJ cord-010092-uftc8inx 12050 43 enough enough RB cord-010092-uftc8inx 12050 44 . . . cord-010092-uftc8inx 12051 1 Therefore therefore RB cord-010092-uftc8inx 12051 2 , , , cord-010092-uftc8inx 12051 3 you -PRON- PRP cord-010092-uftc8inx 12051 4 need need VBP cord-010092-uftc8inx 12051 5 to to TO cord-010092-uftc8inx 12051 6 know know VB cord-010092-uftc8inx 12051 7 , , , cord-010092-uftc8inx 12051 8 when when WRB cord-010092-uftc8inx 12051 9 it -PRON- PRP cord-010092-uftc8inx 12051 10 is be VBZ cord-010092-uftc8inx 12051 11 feasible feasible JJ cord-010092-uftc8inx 12051 12 to to TO cord-010092-uftc8inx 12051 13 increase increase VB cord-010092-uftc8inx 12051 14 the the DT cord-010092-uftc8inx 12051 15 volume volume NN cord-010092-uftc8inx 12051 16 and and CC cord-010092-uftc8inx 12051 17 thereby thereby RB cord-010092-uftc8inx 12051 18 increasing increase VBG cord-010092-uftc8inx 12051 19 the the DT cord-010092-uftc8inx 12051 20 time time NN cord-010092-uftc8inx 12051 21 of of IN cord-010092-uftc8inx 12051 22 the the DT cord-010092-uftc8inx 12051 23 procedure procedure NN cord-010092-uftc8inx 12051 24 with with IN cord-010092-uftc8inx 12051 25 the the DT cord-010092-uftc8inx 12051 26 intention intention NN cord-010092-uftc8inx 12051 27 to to TO cord-010092-uftc8inx 12051 28 collect collect VB cord-010092-uftc8inx 12051 29 all all PDT cord-010092-uftc8inx 12051 30 the the DT cord-010092-uftc8inx 12051 31 requested request VBN cord-010092-uftc8inx 12051 32 cells cell NNS cord-010092-uftc8inx 12051 33 in in IN cord-010092-uftc8inx 12051 34 1 1 CD cord-010092-uftc8inx 12051 35 day day NN cord-010092-uftc8inx 12051 36 . . . cord-010092-uftc8inx 12052 1 It -PRON- PRP cord-010092-uftc8inx 12052 2 can can MD cord-010092-uftc8inx 12052 3 also also RB cord-010092-uftc8inx 12052 4 show show VB cord-010092-uftc8inx 12052 5 if if IN cord-010092-uftc8inx 12052 6 it -PRON- PRP cord-010092-uftc8inx 12052 7 is be VBZ cord-010092-uftc8inx 12052 8 possible possible JJ cord-010092-uftc8inx 12052 9 to to TO cord-010092-uftc8inx 12052 10 reduce reduce VB cord-010092-uftc8inx 12052 11 the the DT cord-010092-uftc8inx 12052 12 volume volume NN cord-010092-uftc8inx 12052 13 of of IN cord-010092-uftc8inx 12052 14 blood blood NN cord-010092-uftc8inx 12052 15 processed process VBN cord-010092-uftc8inx 12052 16 , , , cord-010092-uftc8inx 12052 17 thereby thereby RB cord-010092-uftc8inx 12052 18 reducing reduce VBG cord-010092-uftc8inx 12052 19 the the DT cord-010092-uftc8inx 12052 20 time time NN cord-010092-uftc8inx 12052 21 of of IN cord-010092-uftc8inx 12052 22 the the DT cord-010092-uftc8inx 12052 23 procedure procedure NN cord-010092-uftc8inx 12052 24 . . . cord-010092-uftc8inx 12053 1 Aims aim VBZ cord-010092-uftc8inx 12053 2 : : : cord-010092-uftc8inx 12053 3 To to TO cord-010092-uftc8inx 12053 4 develop develop VB cord-010092-uftc8inx 12053 5 an an DT cord-010092-uftc8inx 12053 6 easy easy JJ cord-010092-uftc8inx 12053 7 tool tool NN cord-010092-uftc8inx 12053 8 to to TO cord-010092-uftc8inx 12053 9 calculate calculate VB cord-010092-uftc8inx 12053 10 the the DT cord-010092-uftc8inx 12053 11 volume volume NN cord-010092-uftc8inx 12053 12 of of IN cord-010092-uftc8inx 12053 13 blood blood NN cord-010092-uftc8inx 12053 14 processed process VBN cord-010092-uftc8inx 12053 15 in in IN cord-010092-uftc8inx 12053 16 order order NN cord-010092-uftc8inx 12053 17 to to TO cord-010092-uftc8inx 12053 18 collect collect VB cord-010092-uftc8inx 12053 19 the the DT cord-010092-uftc8inx 12053 20 requested request VBN cord-010092-uftc8inx 12053 21 cells cell NNS cord-010092-uftc8inx 12053 22 in in IN cord-010092-uftc8inx 12053 23 1 1 CD cord-010092-uftc8inx 12053 24 day day NN cord-010092-uftc8inx 12053 25 . . . cord-010092-uftc8inx 12054 1 Methods method NNS cord-010092-uftc8inx 12054 2 : : : cord-010092-uftc8inx 12055 1 The the DT cord-010092-uftc8inx 12055 2 mean mean JJ cord-010092-uftc8inx 12055 3 collection collection NN cord-010092-uftc8inx 12055 4 efficiency efficiency NN cord-010092-uftc8inx 12055 5 ( ( -LRB- cord-010092-uftc8inx 12055 6 CE CE NNP cord-010092-uftc8inx 12055 7 ) ) -RRB- cord-010092-uftc8inx 12055 8 was be VBD cord-010092-uftc8inx 12055 9 calculated calculate VBN cord-010092-uftc8inx 12055 10 . . . cord-010092-uftc8inx 12056 1 CE CE NNP cord-010092-uftc8inx 12056 2 is be VBZ cord-010092-uftc8inx 12056 3 calculated calculate VBN cord-010092-uftc8inx 12056 4 as as IN cord-010092-uftc8inx 12056 5 CD34 CD34 NNP cord-010092-uftc8inx 12056 6 + + CC cord-010092-uftc8inx 12056 7 cells cell NNS cord-010092-uftc8inx 12056 8 collected/(pre collected/(pre CD cord-010092-uftc8inx 12056 9 - - HYPH cord-010092-uftc8inx 12056 10 apheresis apheresis NN cord-010092-uftc8inx 12056 11 CD34 CD34 NNP cord-010092-uftc8inx 12056 12 + + CC cord-010092-uftc8inx 12056 13 number*processed number*processed CD cord-010092-uftc8inx 12056 14 volume)*100 volume)*100 NNS cord-010092-uftc8inx 12056 15 % % NN cord-010092-uftc8inx 12056 16 . . . cord-010092-uftc8inx 12057 1 Based base VBN cord-010092-uftc8inx 12057 2 on on IN cord-010092-uftc8inx 12057 3 the the DT cord-010092-uftc8inx 12057 4 mean mean NN cord-010092-uftc8inx 12057 5 CE CE NNP cord-010092-uftc8inx 12057 6 , , , cord-010092-uftc8inx 12057 7 an an DT cord-010092-uftc8inx 12057 8 excel excel NNP cord-010092-uftc8inx 12057 9 sheet sheet NN cord-010092-uftc8inx 12057 10 was be VBD cord-010092-uftc8inx 12057 11 generated generate VBN cord-010092-uftc8inx 12057 12 to to TO cord-010092-uftc8inx 12057 13 calculate calculate VB cord-010092-uftc8inx 12057 14 the the DT cord-010092-uftc8inx 12057 15 volume volume NN cord-010092-uftc8inx 12057 16 of of IN cord-010092-uftc8inx 12057 17 blood blood NN cord-010092-uftc8inx 12057 18 that that WDT cord-010092-uftc8inx 12057 19 should should MD cord-010092-uftc8inx 12057 20 be be VB cord-010092-uftc8inx 12057 21 processed process VBN cord-010092-uftc8inx 12057 22 in in IN cord-010092-uftc8inx 12057 23 order order NN cord-010092-uftc8inx 12057 24 to to TO cord-010092-uftc8inx 12057 25 collect collect VB cord-010092-uftc8inx 12057 26 all all PDT cord-010092-uftc8inx 12057 27 the the DT cord-010092-uftc8inx 12057 28 requested request VBN cord-010092-uftc8inx 12057 29 cells cell NNS cord-010092-uftc8inx 12057 30 . . . cord-010092-uftc8inx 12058 1 The the DT cord-010092-uftc8inx 12058 2 excel excel JJ cord-010092-uftc8inx 12058 3 sheet sheet NN cord-010092-uftc8inx 12058 4 is be VBZ cord-010092-uftc8inx 12058 5 designed design VBN cord-010092-uftc8inx 12058 6 so so IN cord-010092-uftc8inx 12058 7 the the DT cord-010092-uftc8inx 12058 8 user user NN cord-010092-uftc8inx 12058 9 enters enter VBZ cord-010092-uftc8inx 12058 10 the the DT cord-010092-uftc8inx 12058 11 pre pre JJ cord-010092-uftc8inx 12058 12 - - JJ cord-010092-uftc8inx 12058 13 apheresis apheresis NN cord-010092-uftc8inx 12058 14 CD34 CD34 NNP cord-010092-uftc8inx 12059 1 + + CC cord-010092-uftc8inx 12060 1 number number NN cord-010092-uftc8inx 12060 2 , , , cord-010092-uftc8inx 12060 3 patient patient JJ cord-010092-uftc8inx 12060 4 weight weight NN cord-010092-uftc8inx 12060 5 and and CC cord-010092-uftc8inx 12060 6 the the DT cord-010092-uftc8inx 12060 7 requested request VBN cord-010092-uftc8inx 12060 8 number number NN cord-010092-uftc8inx 12060 9 of of IN cord-010092-uftc8inx 12060 10 CD34 CD34 NNP cord-010092-uftc8inx 12060 11 + + CC cord-010092-uftc8inx 12060 12 cells cell NNS cord-010092-uftc8inx 12060 13 . . . cord-010092-uftc8inx 12061 1 The the DT cord-010092-uftc8inx 12061 2 CE CE NNP cord-010092-uftc8inx 12061 3 is be VBZ cord-010092-uftc8inx 12061 4 fixed fix VBN cord-010092-uftc8inx 12061 5 according accord VBG cord-010092-uftc8inx 12061 6 to to IN cord-010092-uftc8inx 12061 7 the the DT cord-010092-uftc8inx 12061 8 mean mean NN cord-010092-uftc8inx 12061 9 CE CE NNP cord-010092-uftc8inx 12061 10 calculated calculate VBN cord-010092-uftc8inx 12061 11 . . . cord-010092-uftc8inx 12062 1 The the DT cord-010092-uftc8inx 12062 2 result result NN cord-010092-uftc8inx 12062 3 is be VBZ cord-010092-uftc8inx 12062 4 the the DT cord-010092-uftc8inx 12062 5 volume volume NN cord-010092-uftc8inx 12062 6 of of IN cord-010092-uftc8inx 12062 7 blood blood NN cord-010092-uftc8inx 12062 8 processed process VBN cord-010092-uftc8inx 12062 9 in in IN cord-010092-uftc8inx 12062 10 order order NN cord-010092-uftc8inx 12062 11 to to TO cord-010092-uftc8inx 12062 12 collect collect VB cord-010092-uftc8inx 12062 13 the the DT cord-010092-uftc8inx 12062 14 requested request VBN cord-010092-uftc8inx 12062 15 yield yield NN cord-010092-uftc8inx 12062 16 . . . cord-010092-uftc8inx 12063 1 Based base VBN cord-010092-uftc8inx 12063 2 on on IN cord-010092-uftc8inx 12063 3 that that DT cord-010092-uftc8inx 12063 4 result result NN cord-010092-uftc8inx 12063 5 , , , cord-010092-uftc8inx 12063 6 the the DT cord-010092-uftc8inx 12063 7 apheresis apheresis NN cord-010092-uftc8inx 12063 8 machine machine NN cord-010092-uftc8inx 12063 9 will will MD cord-010092-uftc8inx 12063 10 provide provide VB cord-010092-uftc8inx 12063 11 time time NN cord-010092-uftc8inx 12063 12 for for IN cord-010092-uftc8inx 12063 13 the the DT cord-010092-uftc8inx 12063 14 procedure procedure NN cord-010092-uftc8inx 12063 15 , , , cord-010092-uftc8inx 12063 16 thereby thereby RB cord-010092-uftc8inx 12063 17 it -PRON- PRP cord-010092-uftc8inx 12063 18 is be VBZ cord-010092-uftc8inx 12063 19 possible possible JJ cord-010092-uftc8inx 12063 20 to to TO cord-010092-uftc8inx 12063 21 evaluate evaluate VB cord-010092-uftc8inx 12063 22 if if IN cord-010092-uftc8inx 12063 23 the the DT cord-010092-uftc8inx 12063 24 collection collection NN cord-010092-uftc8inx 12063 25 can can MD cord-010092-uftc8inx 12063 26 be be VB cord-010092-uftc8inx 12063 27 finished finish VBN cord-010092-uftc8inx 12063 28 in in IN cord-010092-uftc8inx 12063 29 1 1 CD cord-010092-uftc8inx 12063 30 day day NN cord-010092-uftc8inx 12063 31 or or CC cord-010092-uftc8inx 12063 32 not not RB cord-010092-uftc8inx 12063 33 , , , cord-010092-uftc8inx 12063 34 e.g. e.g. RB cord-010092-uftc8inx 12063 35 by by IN cord-010092-uftc8inx 12063 36 increasing increase VBG cord-010092-uftc8inx 12063 37 the the DT cord-010092-uftc8inx 12063 38 volume volume NN cord-010092-uftc8inx 12063 39 of of IN cord-010092-uftc8inx 12063 40 blood blood NN cord-010092-uftc8inx 12063 41 processed process VBN cord-010092-uftc8inx 12063 42 . . . cord-010092-uftc8inx 12064 1 Spectra Spectra NNP cord-010092-uftc8inx 12064 2 Optia Optia NNP cord-010092-uftc8inx 12065 1 â â LS cord-010092-uftc8inx 12065 2 was be VBD cord-010092-uftc8inx 12065 3 used use VBN cord-010092-uftc8inx 12065 4 for for IN cord-010092-uftc8inx 12065 5 all all DT cord-010092-uftc8inx 12065 6 collections collection NNS cord-010092-uftc8inx 12065 7 , , , cord-010092-uftc8inx 12065 8 CMNC CMNC NNS cord-010092-uftc8inx 12065 9 for for IN cord-010092-uftc8inx 12065 10 allogeneic allogeneic NN cord-010092-uftc8inx 12065 11 donors donor NNS cord-010092-uftc8inx 12065 12 and and CC cord-010092-uftc8inx 12065 13 MNC MNC NNP cord-010092-uftc8inx 12065 14 for for IN cord-010092-uftc8inx 12065 15 autologous autologous JJ cord-010092-uftc8inx 12065 16 patients patient NNS cord-010092-uftc8inx 12065 17 . . . cord-010092-uftc8inx 12066 1 Results result NNS cord-010092-uftc8inx 12066 2 : : : cord-010092-uftc8inx 12067 1 Mean mean JJ cord-010092-uftc8inx 12067 2 CE CE NNP cord-010092-uftc8inx 12067 3 = = SYM cord-010092-uftc8inx 12067 4 64 64 CD cord-010092-uftc8inx 12067 5 % % NN cord-010092-uftc8inx 12067 6 ( ( -LRB- cord-010092-uftc8inx 12067 7 n n NN cord-010092-uftc8inx 12067 8 = = SYM cord-010092-uftc8inx 12067 9 348 348 CD cord-010092-uftc8inx 12067 10 ) ) -RRB- cord-010092-uftc8inx 12067 11 . . . cord-010092-uftc8inx 12068 1 A a DT cord-010092-uftc8inx 12068 2 CE ce NN cord-010092-uftc8inx 12068 3 of of IN cord-010092-uftc8inx 12068 4 40 40 CD cord-010092-uftc8inx 12068 5 % % NN cord-010092-uftc8inx 12068 6 was be VBD cord-010092-uftc8inx 12068 7 chosen choose VBN cord-010092-uftc8inx 12068 8 as as IN cord-010092-uftc8inx 12068 9 the the DT cord-010092-uftc8inx 12068 10 cut cut NN cord-010092-uftc8inx 12068 11 - - HYPH cord-010092-uftc8inx 12068 12 off off NN cord-010092-uftc8inx 12068 13 for for IN cord-010092-uftc8inx 12068 14 the the DT cord-010092-uftc8inx 12068 15 CD34 CD34 NNP cord-010092-uftc8inx 12068 16 calculation calculation NN cord-010092-uftc8inx 12068 17 tool tool NN cord-010092-uftc8inx 12068 18 . . . cord-010092-uftc8inx 12069 1 Using use VBG cord-010092-uftc8inx 12069 2 the the DT cord-010092-uftc8inx 12069 3 CD34 CD34 NNP cord-010092-uftc8inx 12069 4 calculation calculation NN cord-010092-uftc8inx 12069 5 tool tool NN cord-010092-uftc8inx 12069 6 : : : cord-010092-uftc8inx 12069 7 Allogeneic Allogeneic NNP cord-010092-uftc8inx 12069 8 donors donor NNS cord-010092-uftc8inx 12069 9 ( ( -LRB- cord-010092-uftc8inx 12069 10 n n NN cord-010092-uftc8inx 12069 11 = = SYM cord-010092-uftc8inx 12069 12 61 61 CD cord-010092-uftc8inx 12069 13 ) ) -RRB- cord-010092-uftc8inx 12069 14 : : : cord-010092-uftc8inx 12069 15 mean mean VB cord-010092-uftc8inx 12069 16 CE CE NNP cord-010092-uftc8inx 12069 17 = = SYM cord-010092-uftc8inx 12069 18 61 61 CD cord-010092-uftc8inx 12069 19 % % NN cord-010092-uftc8inx 12069 20 , , , cord-010092-uftc8inx 12069 21 mean mean VB cord-010092-uftc8inx 12069 22 blood blood NN cord-010092-uftc8inx 12069 23 volume volume NN cord-010092-uftc8inx 12069 24 processed process VBN cord-010092-uftc8inx 12069 25 = = SYM cord-010092-uftc8inx 12069 26 3.3 3.3 CD cord-010092-uftc8inx 12069 27 9 9 CD cord-010092-uftc8inx 12069 28 TBV tbv NN cord-010092-uftc8inx 12069 29 , , , cord-010092-uftc8inx 12070 1 mean mean JJ cord-010092-uftc8inx 12070 2 time time NN cord-010092-uftc8inx 12070 3 : : : cord-010092-uftc8inx 12070 4 253 253 CD cord-010092-uftc8inx 12070 5 min min NN cord-010092-uftc8inx 12070 6 , , , cord-010092-uftc8inx 12070 7 37 37 CD cord-010092-uftc8inx 12070 8 donors donor NNS cord-010092-uftc8inx 12070 9 were be VBD cord-010092-uftc8inx 12070 10 finished finish VBN cord-010092-uftc8inx 12070 11 in in IN cord-010092-uftc8inx 12070 12 1 1 CD cord-010092-uftc8inx 12070 13 day day NN cord-010092-uftc8inx 12070 14 collection collection NN cord-010092-uftc8inx 12070 15 ( ( -LRB- cord-010092-uftc8inx 12070 16 61 61 CD cord-010092-uftc8inx 12070 17 % % NN cord-010092-uftc8inx 12070 18 ) ) -RRB- cord-010092-uftc8inx 12071 1 Autologous autologous JJ cord-010092-uftc8inx 12071 2 patients patient NNS cord-010092-uftc8inx 12071 3 ( ( -LRB- cord-010092-uftc8inx 12071 4 n n NN cord-010092-uftc8inx 12071 5 = = SYM cord-010092-uftc8inx 12071 6 205 205 CD cord-010092-uftc8inx 12071 7 ) ) -RRB- cord-010092-uftc8inx 12071 8 : : : cord-010092-uftc8inx 12072 1 mean mean UH cord-010092-uftc8inx 12072 2 CE CE NNP cord-010092-uftc8inx 12072 3 = = SYM cord-010092-uftc8inx 12072 4 65 65 CD cord-010092-uftc8inx 12072 5 % % NN cord-010092-uftc8inx 12072 6 , , , cord-010092-uftc8inx 12073 1 mean mean VB cord-010092-uftc8inx 12073 2 blood blood NN cord-010092-uftc8inx 12073 3 volume volume NN cord-010092-uftc8inx 12073 4 processed process VBN cord-010092-uftc8inx 12073 5 = = NFP cord-010092-uftc8inx 12074 1 2.4 2.4 CD cord-010092-uftc8inx 12074 2 9 9 CD cord-010092-uftc8inx 12074 3 TBV tbv NN cord-010092-uftc8inx 12074 4 , , , cord-010092-uftc8inx 12074 5 mean mean JJ cord-010092-uftc8inx 12074 6 time time NN cord-010092-uftc8inx 12074 7 = = SYM cord-010092-uftc8inx 12074 8 218 218 CD cord-010092-uftc8inx 12074 9 min min NN cord-010092-uftc8inx 12074 10 , , , cord-010092-uftc8inx 12074 11 173 173 CD cord-010092-uftc8inx 12074 12 patients patient NNS cord-010092-uftc8inx 12074 13 were be VBD cord-010092-uftc8inx 12074 14 finished finish VBN cord-010092-uftc8inx 12074 15 in in IN cord-010092-uftc8inx 12074 16 1 1 CD cord-010092-uftc8inx 12074 17 day day NN cord-010092-uftc8inx 12074 18 ( ( -LRB- cord-010092-uftc8inx 12074 19 83 83 CD cord-010092-uftc8inx 12074 20 % % NN cord-010092-uftc8inx 12074 21 ) ) -RRB- cord-010092-uftc8inx 12074 22 . . . cord-010092-uftc8inx 12075 1 The the DT cord-010092-uftc8inx 12075 2 calculation calculation NN cord-010092-uftc8inx 12075 3 failed fail VBD cord-010092-uftc8inx 12075 4 in in IN cord-010092-uftc8inx 12075 5 only only RB cord-010092-uftc8inx 12075 6 1 1 CD cord-010092-uftc8inx 12075 7 case case NN cord-010092-uftc8inx 12075 8 ( ( -LRB- cord-010092-uftc8inx 12075 9 0.4 0.4 CD cord-010092-uftc8inx 12075 10 % % NN cord-010092-uftc8inx 12075 11 ) ) -RRB- cord-010092-uftc8inx 12075 12 . . . cord-010092-uftc8inx 12076 1 In in IN cord-010092-uftc8inx 12076 2 this this DT cord-010092-uftc8inx 12076 3 case case NN cord-010092-uftc8inx 12076 4 the the DT cord-010092-uftc8inx 12076 5 volume volume NN cord-010092-uftc8inx 12076 6 of of IN cord-010092-uftc8inx 12076 7 blood blood NN cord-010092-uftc8inx 12076 8 processed process VBN cord-010092-uftc8inx 12076 9 was be VBD cord-010092-uftc8inx 12076 10 reduced reduce VBN cord-010092-uftc8inx 12076 11 according accord VBG cord-010092-uftc8inx 12076 12 to to IN cord-010092-uftc8inx 12076 13 the the DT cord-010092-uftc8inx 12076 14 calculation calculation NN cord-010092-uftc8inx 12076 15 , , , cord-010092-uftc8inx 12076 16 but but CC cord-010092-uftc8inx 12076 17 because because IN cord-010092-uftc8inx 12076 18 of of IN cord-010092-uftc8inx 12076 19 unexpected unexpected JJ cord-010092-uftc8inx 12076 20 low low JJ cord-010092-uftc8inx 12076 21 CE ce NN cord-010092-uftc8inx 12076 22 , , , cord-010092-uftc8inx 12076 23 the the DT cord-010092-uftc8inx 12076 24 requested request VBN cord-010092-uftc8inx 12076 25 number number NN cord-010092-uftc8inx 12076 26 of of IN cord-010092-uftc8inx 12076 27 cells cell NNS cord-010092-uftc8inx 12076 28 was be VBD cord-010092-uftc8inx 12076 29 not not RB cord-010092-uftc8inx 12076 30 achieved achieve VBN cord-010092-uftc8inx 12076 31 . . . cord-010092-uftc8inx 12077 1 Summary Summary NNP cord-010092-uftc8inx 12077 2 / / SYM cord-010092-uftc8inx 12077 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 12077 4 : : : cord-010092-uftc8inx 12078 1 The the DT cord-010092-uftc8inx 12078 2 CD34 CD34 NNP cord-010092-uftc8inx 12078 3 calculation calculation NN cord-010092-uftc8inx 12078 4 tool tool NN cord-010092-uftc8inx 12078 5 based base VBN cord-010092-uftc8inx 12078 6 on on IN cord-010092-uftc8inx 12078 7 an an DT cord-010092-uftc8inx 12078 8 excel excel JJ cord-010092-uftc8inx 12078 9 sheet sheet NN cord-010092-uftc8inx 12078 10 has have VBZ cord-010092-uftc8inx 12078 11 shown show VBN cord-010092-uftc8inx 12078 12 to to TO cord-010092-uftc8inx 12078 13 be be VB cord-010092-uftc8inx 12078 14 simple simple JJ cord-010092-uftc8inx 12078 15 and and CC cord-010092-uftc8inx 12078 16 easy easy JJ cord-010092-uftc8inx 12078 17 to to TO cord-010092-uftc8inx 12078 18 use use VB cord-010092-uftc8inx 12078 19 in in IN cord-010092-uftc8inx 12078 20 order order NN cord-010092-uftc8inx 12078 21 to to TO cord-010092-uftc8inx 12078 22 personalize personalize VB cord-010092-uftc8inx 12078 23 the the DT cord-010092-uftc8inx 12078 24 stem stem NN cord-010092-uftc8inx 12078 25 cell cell NN cord-010092-uftc8inx 12078 26 collection collection NN cord-010092-uftc8inx 12078 27 . . . cord-010092-uftc8inx 12079 1 IMMUNOTHERAPY immunotherapy NN cord-010092-uftc8inx 12079 2 PRODUCTS product NNS cord-010092-uftc8inx 12079 3 : : : cord-010092-uftc8inx 12079 4 BLOOD blood NN cord-010092-uftc8inx 12079 5 PRODUCT product NN cord-010092-uftc8inx 12079 6 , , , cord-010092-uftc8inx 12079 7 PHARMACEUTICAL pharmaceutical NN cord-010092-uftc8inx 12079 8 , , , cord-010092-uftc8inx 12079 9 OR or CC cord-010092-uftc8inx 12079 10 A a DT cord-010092-uftc8inx 12079 11 NEW new JJ cord-010092-uftc8inx 12079 12 CATEGORY category NN cord-010092-uftc8inx 12080 1 ALL all RB cord-010092-uftc8inx 12080 2 TOGETHER together RB cord-010092-uftc8inx 12080 3 ? ? . cord-010092-uftc8inx 12081 1 from from IN cord-010092-uftc8inx 12081 2 2001 2001 CD cord-010092-uftc8inx 12081 3 till till IN cord-010092-uftc8inx 12081 4 2019 2019 CD cord-010092-uftc8inx 12081 5 . . . cord-010092-uftc8inx 12082 1 All all DT cord-010092-uftc8inx 12082 2 donors donor NNS cord-010092-uftc8inx 12082 3 were be VBD cord-010092-uftc8inx 12082 4 HLA HLA NNP cord-010092-uftc8inx 12082 5 typed type VBN cord-010092-uftc8inx 12082 6 and and CC cord-010092-uftc8inx 12082 7 matched match VBN cord-010092-uftc8inx 12082 8 ; ; : cord-010092-uftc8inx 12082 9 they -PRON- PRP cord-010092-uftc8inx 12082 10 were be VBD cord-010092-uftc8inx 12082 11 fully fully RB cord-010092-uftc8inx 12082 12 informed inform VBN cord-010092-uftc8inx 12082 13 on on IN cord-010092-uftc8inx 12082 14 the the DT cord-010092-uftc8inx 12082 15 donation donation NN cord-010092-uftc8inx 12082 16 procedure procedure NN cord-010092-uftc8inx 12082 17 and and CC cord-010092-uftc8inx 12082 18 signed sign VBD cord-010092-uftc8inx 12082 19 an an DT cord-010092-uftc8inx 12082 20 informed informed JJ cord-010092-uftc8inx 12082 21 consent consent NN cord-010092-uftc8inx 12082 22 for for IN cord-010092-uftc8inx 12082 23 donation donation NN cord-010092-uftc8inx 12082 24 . . . cord-010092-uftc8inx 12083 1 Minimum minimum JJ cord-010092-uftc8inx 12083 2 dose dose NN cord-010092-uftc8inx 12083 3 required require VBN cord-010092-uftc8inx 12083 4 to to TO cord-010092-uftc8inx 12083 5 ensure ensure VB cord-010092-uftc8inx 12083 6 successful successful JJ cord-010092-uftc8inx 12083 7 and and CC cord-010092-uftc8inx 12083 8 sustained sustained JJ cord-010092-uftc8inx 12083 9 engraftment engraftment NN cord-010092-uftc8inx 12083 10 was be VBD cord-010092-uftc8inx 12083 11 2 2 CD cord-010092-uftc8inx 12083 12 9 9 CD cord-010092-uftc8inx 12083 13 10 10 CD cord-010092-uftc8inx 12083 14 6 6 CD cord-010092-uftc8inx 12084 1 /kg /kg . cord-010092-uftc8inx 12085 1 CD34 CD34 NNP cord-010092-uftc8inx 12085 2 + + CC cord-010092-uftc8inx 12085 3 cells cell NNS cord-010092-uftc8inx 12085 4 and and CC cord-010092-uftc8inx 12085 5 2 2 CD cord-010092-uftc8inx 12085 6 9 9 CD cord-010092-uftc8inx 12085 7 10 10 CD cord-010092-uftc8inx 12085 8 8 8 CD cord-010092-uftc8inx 12085 9 /kg /kg CD cord-010092-uftc8inx 12085 10 mono mono NN cord-010092-uftc8inx 12085 11 - - HYPH cord-010092-uftc8inx 12085 12 nucleated nucleated JJ cord-010092-uftc8inx 12085 13 cells cell NNS cord-010092-uftc8inx 12085 14 ( ( -LRB- cord-010092-uftc8inx 12085 15 MNC MNC NNP cord-010092-uftc8inx 12085 16 ) ) -RRB- cord-010092-uftc8inx 12085 17 . . . cord-010092-uftc8inx 12086 1 PBSC PBSC NNP cord-010092-uftc8inx 12086 2 harvesting harvesting NN cord-010092-uftc8inx 12086 3 was be VBD cord-010092-uftc8inx 12086 4 performed perform VBN cord-010092-uftc8inx 12086 5 with with IN cord-010092-uftc8inx 12086 6 continuous continuous JJ cord-010092-uftc8inx 12086 7 flow flow NN cord-010092-uftc8inx 12086 8 cell cell NN cord-010092-uftc8inx 12086 9 separator separator NN cord-010092-uftc8inx 12086 10 Baxter Baxter NNP cord-010092-uftc8inx 12086 11 C53000 C53000 NNP cord-010092-uftc8inx 12086 12 , , , cord-010092-uftc8inx 12086 13 COBE COBE NNP cord-010092-uftc8inx 12086 14 Spectra Spectra NNP cord-010092-uftc8inx 12086 15 and and CC cord-010092-uftc8inx 12086 16 Spectra Spectra NNP cord-010092-uftc8inx 12086 17 Optia Optia NNP cord-010092-uftc8inx 12086 18 using use VBG cord-010092-uftc8inx 12086 19 conventional conventional JJ cord-010092-uftc8inx 12086 20 - - HYPH cord-010092-uftc8inx 12086 21 volume volume NN cord-010092-uftc8inx 12086 22 apheresis apheresis NN cord-010092-uftc8inx 12086 23 processing process VBG cord-010092-uftc8inx 12086 24 the the DT cord-010092-uftc8inx 12086 25 2 2 CD cord-010092-uftc8inx 12086 26 - - SYM cord-010092-uftc8inx 12086 27 2.5 2.5 CD cord-010092-uftc8inx 12086 28 total total JJ cord-010092-uftc8inx 12086 29 blood blood NN cord-010092-uftc8inx 12086 30 volumes volume NNS cord-010092-uftc8inx 12086 31 per per IN cord-010092-uftc8inx 12086 32 apheresis apheresis NN cord-010092-uftc8inx 12086 33 . . . cord-010092-uftc8inx 12087 1 A a DT cord-010092-uftc8inx 12087 2 femoral femoral JJ cord-010092-uftc8inx 12087 3 catheter catheter NN cord-010092-uftc8inx 12087 4 was be VBD cord-010092-uftc8inx 12087 5 used use VBN cord-010092-uftc8inx 12087 6 for for IN cord-010092-uftc8inx 12087 7 harvesting harvesting NN cord-010092-uftc8inx 12087 8 and and CC cord-010092-uftc8inx 12087 9 Acid Acid NNP cord-010092-uftc8inx 12087 10 Citrate Citrate NNP cord-010092-uftc8inx 12087 11 Dextrose Dextrose NNP cord-010092-uftc8inx 12087 12 formula formula NN cord-010092-uftc8inx 12087 13 A a NN cord-010092-uftc8inx 12087 14 is be VBZ cord-010092-uftc8inx 12087 15 used use VBN cord-010092-uftc8inx 12087 16 for for IN cord-010092-uftc8inx 12087 17 anticoagulation anticoagulation NN cord-010092-uftc8inx 12087 18 . . . cord-010092-uftc8inx 12088 1 Recombinant recombinant JJ cord-010092-uftc8inx 12088 2 human human JJ cord-010092-uftc8inx 12088 3 granulocyte granulocyte NN cord-010092-uftc8inx 12088 4 colony colony NN cord-010092-uftc8inx 12088 5 - - HYPH cord-010092-uftc8inx 12088 6 stimulating stimulate VBG cord-010092-uftc8inx 12088 7 factor factor NN cord-010092-uftc8inx 12088 8 ( ( -LRB- cord-010092-uftc8inx 12088 9 G G NNP cord-010092-uftc8inx 12088 10 - - HYPH cord-010092-uftc8inx 12088 11 CSF CSF NNP cord-010092-uftc8inx 12088 12 ) ) -RRB- cord-010092-uftc8inx 12088 13 is be VBZ cord-010092-uftc8inx 12088 14 used use VBN cord-010092-uftc8inx 12088 15 to to TO cord-010092-uftc8inx 12088 16 mobilize mobilize VB cord-010092-uftc8inx 12088 17 PBPC PBPC NNP cord-010092-uftc8inx 12088 18 for for IN cord-010092-uftc8inx 12088 19 collection collection NN cord-010092-uftc8inx 12088 20 . . . cord-010092-uftc8inx 12089 1 Harvesting harvesting NN cord-010092-uftc8inx 12089 2 of of IN cord-010092-uftc8inx 12089 3 PBSC PBSC NNP cord-010092-uftc8inx 12089 4 is be VBZ cord-010092-uftc8inx 12089 5 usually usually RB cord-010092-uftc8inx 12089 6 performed perform VBN cord-010092-uftc8inx 12089 7 after after IN cord-010092-uftc8inx 12089 8 4 4 CD cord-010092-uftc8inx 12089 9 to to TO cord-010092-uftc8inx 12089 10 5 5 CD cord-010092-uftc8inx 12089 11 days day NNS cord-010092-uftc8inx 12089 12 of of IN cord-010092-uftc8inx 12089 13 G G NNP cord-010092-uftc8inx 12089 14 - - HYPH cord-010092-uftc8inx 12089 15 CSF CSF NNP cord-010092-uftc8inx 12089 16 subcutaneous subcutaneous JJ cord-010092-uftc8inx 12089 17 administration administration NN cord-010092-uftc8inx 12089 18 at at IN cord-010092-uftc8inx 12089 19 a a DT cord-010092-uftc8inx 12089 20 dose dose NN cord-010092-uftc8inx 12089 21 of of IN cord-010092-uftc8inx 12089 22 10 10 CD cord-010092-uftc8inx 12089 23 lg lg NN cord-010092-uftc8inx 12089 24 / / SYM cord-010092-uftc8inx 12089 25 kg kg NNP cord-010092-uftc8inx 12089 26 body body NN cord-010092-uftc8inx 12089 27 weight weight NN cord-010092-uftc8inx 12089 28 . . . cord-010092-uftc8inx 12090 1 Results result NNS cord-010092-uftc8inx 12090 2 : : : cord-010092-uftc8inx 12091 1 All all PDT cord-010092-uftc8inx 12091 2 the the DT cord-010092-uftc8inx 12091 3 donors donor NNS cord-010092-uftc8inx 12091 4 were be VBD cord-010092-uftc8inx 12091 5 siblings sibling NNS cord-010092-uftc8inx 12091 6 of of IN cord-010092-uftc8inx 12091 7 the the DT cord-010092-uftc8inx 12091 8 patients patient NNS cord-010092-uftc8inx 12091 9 treated treat VBN cord-010092-uftc8inx 12091 10 at at IN cord-010092-uftc8inx 12091 11 the the DT cord-010092-uftc8inx 12091 12 University University NNP cord-010092-uftc8inx 12091 13 Hematology Hematology NNP cord-010092-uftc8inx 12091 14 Hospital Hospital NNP cord-010092-uftc8inx 12091 15 . . . cord-010092-uftc8inx 12092 1 There there EX cord-010092-uftc8inx 12092 2 were be VBD cord-010092-uftc8inx 12092 3 159 159 CD cord-010092-uftc8inx 12092 4 apheresis apheresis NN cord-010092-uftc8inx 12092 5 procedures procedure NNS cord-010092-uftc8inx 12092 6 performed perform VBN cord-010092-uftc8inx 12092 7 in in IN cord-010092-uftc8inx 12092 8 106 106 CD cord-010092-uftc8inx 12092 9 healthy healthy JJ cord-010092-uftc8inx 12092 10 sibling sibling NN cord-010092-uftc8inx 12092 11 donors donor NNS cord-010092-uftc8inx 12092 12 . . . cord-010092-uftc8inx 12093 1 There there EX cord-010092-uftc8inx 12093 2 were be VBD cord-010092-uftc8inx 12093 3 75 75 CD cord-010092-uftc8inx 12093 4 males male NNS cord-010092-uftc8inx 12093 5 and and CC cord-010092-uftc8inx 12093 6 31 31 CD cord-010092-uftc8inx 12093 7 females female NNS cord-010092-uftc8inx 12093 8 , , , cord-010092-uftc8inx 12093 9 aged aged JJ cord-010092-uftc8inx 12093 10 20 20 CD cord-010092-uftc8inx 12093 11 - - SYM cord-010092-uftc8inx 12093 12 55 55 CD cord-010092-uftc8inx 12093 13 . . . cord-010092-uftc8inx 12094 1 One one CD cord-010092-uftc8inx 12094 2 to to TO cord-010092-uftc8inx 12094 3 two two CD cord-010092-uftc8inx 12094 4 apheresis apheresis NN cord-010092-uftc8inx 12094 5 procedures procedure NNS cord-010092-uftc8inx 12094 6 were be VBD cord-010092-uftc8inx 12094 7 required require VBN cord-010092-uftc8inx 12094 8 to to TO cord-010092-uftc8inx 12094 9 collect collect VB cord-010092-uftc8inx 12094 10 adequate adequate JJ cord-010092-uftc8inx 12094 11 graft graft NN cord-010092-uftc8inx 12094 12 . . . cord-010092-uftc8inx 12095 1 The the DT cord-010092-uftc8inx 12095 2 single single JJ cord-010092-uftc8inx 12095 3 procedure procedure NN cord-010092-uftc8inx 12095 4 usually usually RB cord-010092-uftc8inx 12095 5 took take VBD cord-010092-uftc8inx 12095 6 3 3 CD cord-010092-uftc8inx 12095 7 - - SYM cord-010092-uftc8inx 12095 8 4 4 CD cord-010092-uftc8inx 12095 9 h h NN cord-010092-uftc8inx 12095 10 and and CC cord-010092-uftc8inx 12095 11 the the DT cord-010092-uftc8inx 12095 12 volume volume NN cord-010092-uftc8inx 12095 13 of of IN cord-010092-uftc8inx 12095 14 collected collect VBN cord-010092-uftc8inx 12095 15 stem stem NN cord-010092-uftc8inx 12095 16 cells cell NNS cord-010092-uftc8inx 12095 17 was be VBD cord-010092-uftc8inx 12095 18 50 50 CD cord-010092-uftc8inx 12095 19 - - SYM cord-010092-uftc8inx 12095 20 220 220 CD cord-010092-uftc8inx 12095 21 ml ml NN cord-010092-uftc8inx 12095 22 . . . cord-010092-uftc8inx 12096 1 The the DT cord-010092-uftc8inx 12096 2 needed need VBN cord-010092-uftc8inx 12096 3 number number NN cord-010092-uftc8inx 12096 4 of of IN cord-010092-uftc8inx 12096 5 MNC MNC NNP cord-010092-uftc8inx 12096 6 and and CC cord-010092-uftc8inx 12096 7 CD34 CD34 NNP cord-010092-uftc8inx 12096 8 + + CC cord-010092-uftc8inx 12096 9 cells cell NNS cord-010092-uftc8inx 12096 10 was be VBD cord-010092-uftc8inx 12096 11 successfully successfully RB cord-010092-uftc8inx 12096 12 collected collect VBN cord-010092-uftc8inx 12096 13 by by IN cord-010092-uftc8inx 12096 14 1.5 1.5 CD cord-010092-uftc8inx 12096 15 apheresis apheresis NN cord-010092-uftc8inx 12096 16 . . . cord-010092-uftc8inx 12097 1 There there EX cord-010092-uftc8inx 12097 2 were be VBD cord-010092-uftc8inx 12097 3 29 29 CD cord-010092-uftc8inx 12097 4 ABO ABO NNP cord-010092-uftc8inx 12097 5 incompatible incompatible JJ cord-010092-uftc8inx 12097 6 donors donor NNS cord-010092-uftc8inx 12097 7 . . . cord-010092-uftc8inx 12098 1 Procedures procedure NNS cord-010092-uftc8inx 12098 2 for for IN cord-010092-uftc8inx 12098 3 mobilization mobilization NN cord-010092-uftc8inx 12098 4 and and CC cord-010092-uftc8inx 12098 5 collection collection NN cord-010092-uftc8inx 12098 6 of of IN cord-010092-uftc8inx 12098 7 PBPC PBPC NNP cord-010092-uftc8inx 12098 8 from from IN cord-010092-uftc8inx 12098 9 healthy healthy JJ cord-010092-uftc8inx 12098 10 donors donor NNS cord-010092-uftc8inx 12098 11 are be VBP cord-010092-uftc8inx 12098 12 generally generally RB cord-010092-uftc8inx 12098 13 well well RB cord-010092-uftc8inx 12098 14 tolerated tolerate VBN cord-010092-uftc8inx 12098 15 . . . cord-010092-uftc8inx 12099 1 The the DT cord-010092-uftc8inx 12099 2 only only JJ cord-010092-uftc8inx 12099 3 adverse adverse JJ cord-010092-uftc8inx 12099 4 effects effect NNS cord-010092-uftc8inx 12099 5 of of IN cord-010092-uftc8inx 12099 6 the the DT cord-010092-uftc8inx 12099 7 apheresis apheresis NN cord-010092-uftc8inx 12099 8 procedure procedure NN cord-010092-uftc8inx 12099 9 were be VBD cord-010092-uftc8inx 12099 10 bone bone NN cord-010092-uftc8inx 12099 11 pain pain NN cord-010092-uftc8inx 12099 12 as as IN cord-010092-uftc8inx 12099 13 reaction reaction NN cord-010092-uftc8inx 12099 14 of of IN cord-010092-uftc8inx 12099 15 G G NNP cord-010092-uftc8inx 12099 16 - - HYPH cord-010092-uftc8inx 12099 17 CSF csf NN cord-010092-uftc8inx 12099 18 and and CC cord-010092-uftc8inx 12099 19 numbness numbness NN cord-010092-uftc8inx 12099 20 of of IN cord-010092-uftc8inx 12099 21 the the DT cord-010092-uftc8inx 12099 22 extremities extremity NNS cord-010092-uftc8inx 12099 23 as as IN cord-010092-uftc8inx 12099 24 reaction reaction NN cord-010092-uftc8inx 12099 25 of of IN cord-010092-uftc8inx 12099 26 ACD ACD NNP cord-010092-uftc8inx 12099 27 - - HYPH cord-010092-uftc8inx 12099 28 A a NN cord-010092-uftc8inx 12099 29 ( ( -LRB- cord-010092-uftc8inx 12099 30 hypocalcemia hypocalcemia NN cord-010092-uftc8inx 12099 31 ) ) -RRB- cord-010092-uftc8inx 12099 32 , , , cord-010092-uftc8inx 12099 33 which which WDT cord-010092-uftc8inx 12099 34 occur occur VBP cord-010092-uftc8inx 12099 35 rarely rarely RB cord-010092-uftc8inx 12099 36 and and CC cord-010092-uftc8inx 12099 37 were be VBD cord-010092-uftc8inx 12099 38 very very RB cord-010092-uftc8inx 12099 39 mild mild JJ cord-010092-uftc8inx 12099 40 . . . cord-010092-uftc8inx 12100 1 The the DT cord-010092-uftc8inx 12100 2 collected collect VBN cord-010092-uftc8inx 12100 3 PBSC PBSC NNP cord-010092-uftc8inx 12100 4 were be VBD cord-010092-uftc8inx 12100 5 used use VBN cord-010092-uftc8inx 12100 6 in in IN cord-010092-uftc8inx 12100 7 allogeneic allogeneic JJ cord-010092-uftc8inx 12100 8 stem stem NN cord-010092-uftc8inx 12100 9 cell cell NN cord-010092-uftc8inx 12100 10 transplantation transplantation NN cord-010092-uftc8inx 12100 11 in in IN cord-010092-uftc8inx 12100 12 patients patient NNS cord-010092-uftc8inx 12100 13 with with IN cord-010092-uftc8inx 12100 14 : : : cord-010092-uftc8inx 12100 15 acute acute JJ cord-010092-uftc8inx 12100 16 myeloid myeloid NN cord-010092-uftc8inx 12100 17 leukemia leukemia NN cord-010092-uftc8inx 12101 1 -57 -57 NNP cord-010092-uftc8inx 12101 2 patients patient NNS cord-010092-uftc8inx 12101 3 ( ( -LRB- cord-010092-uftc8inx 12101 4 53.7 53.7 CD cord-010092-uftc8inx 12101 5 % % NN cord-010092-uftc8inx 12101 6 ) ) -RRB- cord-010092-uftc8inx 12101 7 , , , cord-010092-uftc8inx 12101 8 acute acute JJ cord-010092-uftc8inx 12101 9 lymphoblastic lymphoblastic JJ cord-010092-uftc8inx 12101 10 leukemia leukemia NN cord-010092-uftc8inx 12102 1 -14 -14 : cord-010092-uftc8inx 12102 2 patients patient NNS cord-010092-uftc8inx 12102 3 ( ( -LRB- cord-010092-uftc8inx 12102 4 13.2 13.2 CD cord-010092-uftc8inx 12102 5 % % NN cord-010092-uftc8inx 12102 6 ) ) -RRB- cord-010092-uftc8inx 12102 7 , , , cord-010092-uftc8inx 12102 8 chronic chronic JJ cord-010092-uftc8inx 12102 9 myeloid myeloid NN cord-010092-uftc8inx 12102 10 leukemia leukemia NN cord-010092-uftc8inx 12102 11 -9 -9 ADD cord-010092-uftc8inx 12102 12 patients patient NNS cord-010092-uftc8inx 12102 13 ( ( -LRB- cord-010092-uftc8inx 12102 14 8.5 8.5 CD cord-010092-uftc8inx 12102 15 % % NN cord-010092-uftc8inx 12102 16 ) ) -RRB- cord-010092-uftc8inx 12102 17 , , , cord-010092-uftc8inx 12102 18 myeloproliferative myeloproliferative JJ cord-010092-uftc8inx 12102 19 disorders disorder NNS cord-010092-uftc8inx 12102 20 -8 -8 VBG cord-010092-uftc8inx 12102 21 patients patient NNS cord-010092-uftc8inx 12102 22 ( ( -LRB- cord-010092-uftc8inx 12102 23 7.5 7.5 CD cord-010092-uftc8inx 12102 24 % % NN cord-010092-uftc8inx 12102 25 ) ) -RRB- cord-010092-uftc8inx 12102 26 , , , cord-010092-uftc8inx 12102 27 myelofibrosis myelofibrosis NNP cord-010092-uftc8inx 12102 28 -5 -5 NNP cord-010092-uftc8inx 12102 29 patients patient NNS cord-010092-uftc8inx 12102 30 ( ( -LRB- cord-010092-uftc8inx 12102 31 4.7 4.7 CD cord-010092-uftc8inx 12102 32 % % NN cord-010092-uftc8inx 12102 33 ) ) -RRB- cord-010092-uftc8inx 12102 34 , , , cord-010092-uftc8inx 12102 35 severe severe JJ cord-010092-uftc8inx 12102 36 aplastic aplastic JJ cord-010092-uftc8inx 12102 37 anemia anemia NN cord-010092-uftc8inx 12102 38 -5 -5 NNP cord-010092-uftc8inx 12102 39 patient patient NN cord-010092-uftc8inx 12102 40 ( ( -LRB- cord-010092-uftc8inx 12102 41 4.7 4.7 CD cord-010092-uftc8inx 12102 42 % % NN cord-010092-uftc8inx 12102 43 ) ) -RRB- cord-010092-uftc8inx 12102 44 , , , cord-010092-uftc8inx 12102 45 non non JJ cord-010092-uftc8inx 12102 46 - - JJ cord-010092-uftc8inx 12102 47 Hodgkin Hodgkin NNP cord-010092-uftc8inx 12102 48 lymphoma lymphoma NN cord-010092-uftc8inx 12102 49 -3 -3 NN cord-010092-uftc8inx 12102 50 patient patient NN cord-010092-uftc8inx 12102 51 ( ( -LRB- cord-010092-uftc8inx 12102 52 2.8 2.8 CD cord-010092-uftc8inx 12102 53 % % NN cord-010092-uftc8inx 12102 54 ) ) -RRB- cord-010092-uftc8inx 12102 55 , , , cord-010092-uftc8inx 12102 56 multiple multiple JJ cord-010092-uftc8inx 12102 57 myeloma myeloma NN cord-010092-uftc8inx 12102 58 -3 -3 NNP cord-010092-uftc8inx 12102 59 patient patient JJ cord-010092-uftc8inx 12102 60 ( ( -LRB- cord-010092-uftc8inx 12102 61 2.8 2.8 CD cord-010092-uftc8inx 12102 62 % % NN cord-010092-uftc8inx 12102 63 ) ) -RRB- cord-010092-uftc8inx 12102 64 , , , cord-010092-uftc8inx 12102 65 chronic chronic JJ cord-010092-uftc8inx 12102 66 lymphoblastic lymphoblastic NN cord-010092-uftc8inx 12102 67 leukemia leukemia NN cord-010092-uftc8inx 12102 68 -1 -1 . cord-010092-uftc8inx 12102 69 patients patient NNS cord-010092-uftc8inx 12102 70 ( ( -LRB- cord-010092-uftc8inx 12102 71 0.9 0.9 CD cord-010092-uftc8inx 12102 72 ) ) -RRB- cord-010092-uftc8inx 12102 73 , , , cord-010092-uftc8inx 12102 74 Hodgkin Hodgkin NNP cord-010092-uftc8inx 12102 75 disease disease NN cord-010092-uftc8inx 12102 76 -1 -1 NN cord-010092-uftc8inx 12102 77 patient patient JJ cord-010092-uftc8inx 12102 78 ( ( -LRB- cord-010092-uftc8inx 12102 79 0.9 0.9 CD cord-010092-uftc8inx 12102 80 % % NN cord-010092-uftc8inx 12102 81 ) ) -RRB- cord-010092-uftc8inx 12102 82 . . . cord-010092-uftc8inx 12103 1 Summary Summary NNP cord-010092-uftc8inx 12103 2 / / SYM cord-010092-uftc8inx 12103 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 12103 4 : : : cord-010092-uftc8inx 12104 1 The the DT cord-010092-uftc8inx 12104 2 apheresis apheresis NN cord-010092-uftc8inx 12104 3 collection collection NN cord-010092-uftc8inx 12104 4 of of IN cord-010092-uftc8inx 12104 5 PBSC PBSC NNP cord-010092-uftc8inx 12104 6 in in IN cord-010092-uftc8inx 12104 7 healthy healthy JJ cord-010092-uftc8inx 12104 8 donors donor NNS cord-010092-uftc8inx 12104 9 is be VBZ cord-010092-uftc8inx 12104 10 an an DT cord-010092-uftc8inx 12104 11 effective effective JJ cord-010092-uftc8inx 12104 12 and and CC cord-010092-uftc8inx 12104 13 safe safe JJ cord-010092-uftc8inx 12104 14 procedure procedure NN cord-010092-uftc8inx 12104 15 . . . cord-010092-uftc8inx 12105 1 We -PRON- PRP cord-010092-uftc8inx 12105 2 are be VBP cord-010092-uftc8inx 12105 3 developing develop VBG cord-010092-uftc8inx 12105 4 our -PRON- PRP$ cord-010092-uftc8inx 12105 5 National National NNP cord-010092-uftc8inx 12105 6 Stem Stem NNP cord-010092-uftc8inx 12105 7 Cell Cell NNP cord-010092-uftc8inx 12105 8 Donors Donors NNPS cord-010092-uftc8inx 12105 9 Registry Registry NNP cord-010092-uftc8inx 12105 10 as as IN cord-010092-uftc8inx 12105 11 a a DT cord-010092-uftc8inx 12105 12 part part NN cord-010092-uftc8inx 12105 13 of of IN cord-010092-uftc8inx 12105 14 Bone Bone NNP cord-010092-uftc8inx 12105 15 Marrow Marrow NNP cord-010092-uftc8inx 12105 16 Donors Donors NNPS cord-010092-uftc8inx 12105 17 Worldwide Worldwide NNP cord-010092-uftc8inx 12105 18 . . . cord-010092-uftc8inx 12106 1 In in IN cord-010092-uftc8inx 12106 2 that that DT cord-010092-uftc8inx 12106 3 way way NN cord-010092-uftc8inx 12106 4 we -PRON- PRP cord-010092-uftc8inx 12106 5 hope hope VBP cord-010092-uftc8inx 12106 6 we -PRON- PRP cord-010092-uftc8inx 12106 7 will will MD cord-010092-uftc8inx 12106 8 help help VB cord-010092-uftc8inx 12106 9 widen widen VB cord-010092-uftc8inx 12106 10 the the DT cord-010092-uftc8inx 12106 11 world world NN cord-010092-uftc8inx 12106 12 network network NN cord-010092-uftc8inx 12106 13 of of IN cord-010092-uftc8inx 12106 14 stem stem NN cord-010092-uftc8inx 12106 15 cell cell NN cord-010092-uftc8inx 12106 16 donors donor NNS cord-010092-uftc8inx 12106 17 and and CC cord-010092-uftc8inx 12106 18 enlarge enlarge VB cord-010092-uftc8inx 12106 19 the the DT cord-010092-uftc8inx 12106 20 possibility possibility NN cord-010092-uftc8inx 12106 21 for for IN cord-010092-uftc8inx 12106 22 each each DT cord-010092-uftc8inx 12106 23 patient patient NN cord-010092-uftc8inx 12106 24 to to TO cord-010092-uftc8inx 12106 25 find find VB cord-010092-uftc8inx 12106 26 the the DT cord-010092-uftc8inx 12106 27 right right JJ cord-010092-uftc8inx 12106 28 match match NN cord-010092-uftc8inx 12106 29 . . . cord-010092-uftc8inx 12107 1 Background background NN cord-010092-uftc8inx 12107 2 : : : cord-010092-uftc8inx 12108 1 Leukocyte Leukocyte NNP cord-010092-uftc8inx 12108 2 - - HYPH cord-010092-uftc8inx 12108 3 removing remove VBG cord-010092-uftc8inx 12108 4 filters filter NNS cord-010092-uftc8inx 12108 5 for for IN cord-010092-uftc8inx 12108 6 blood blood NN cord-010092-uftc8inx 12108 7 are be VBP cord-010092-uftc8inx 12108 8 being be VBG cord-010092-uftc8inx 12108 9 used use VBN cord-010092-uftc8inx 12108 10 widely widely RB cord-010092-uftc8inx 12108 11 as as IN cord-010092-uftc8inx 12108 12 a a DT cord-010092-uftc8inx 12108 13 universal universal JJ cord-010092-uftc8inx 12108 14 leukocyte leukocyte NN cord-010092-uftc8inx 12108 15 reduction reduction NN cord-010092-uftc8inx 12108 16 policy policy NN cord-010092-uftc8inx 12108 17 is be VBZ cord-010092-uftc8inx 12108 18 being be VBG cord-010092-uftc8inx 12108 19 adopted adopt VBN cord-010092-uftc8inx 12108 20 progressively progressively RB cord-010092-uftc8inx 12108 21 throughout throughout IN cord-010092-uftc8inx 12108 22 the the DT cord-010092-uftc8inx 12108 23 world world NN cord-010092-uftc8inx 12108 24 . . . cord-010092-uftc8inx 12109 1 Filtration filtration NN cord-010092-uftc8inx 12109 2 is be VBZ cord-010092-uftc8inx 12109 3 one one CD cord-010092-uftc8inx 12109 4 of of IN cord-010092-uftc8inx 12109 5 the the DT cord-010092-uftc8inx 12109 6 most most RBS cord-010092-uftc8inx 12109 7 effective effective JJ cord-010092-uftc8inx 12109 8 methods method NNS cord-010092-uftc8inx 12109 9 for for IN cord-010092-uftc8inx 12109 10 preventing prevent VBG cord-010092-uftc8inx 12109 11 various various JJ cord-010092-uftc8inx 12109 12 adverse adverse JJ cord-010092-uftc8inx 12109 13 transfusion transfusion NN cord-010092-uftc8inx 12109 14 effects effect NNS cord-010092-uftc8inx 12109 15 caused cause VBN cord-010092-uftc8inx 12109 16 by by IN cord-010092-uftc8inx 12109 17 leukocytes leukocyte NNS cord-010092-uftc8inx 12109 18 included include VBN cord-010092-uftc8inx 12109 19 in in IN cord-010092-uftc8inx 12109 20 blood blood NN cord-010092-uftc8inx 12109 21 components component NNS cord-010092-uftc8inx 12109 22 , , , cord-010092-uftc8inx 12109 23 such such JJ cord-010092-uftc8inx 12109 24 as as IN cord-010092-uftc8inx 12109 25 febrile febrile JJ cord-010092-uftc8inx 12109 26 reaction reaction NN cord-010092-uftc8inx 12109 27 , , , cord-010092-uftc8inx 12109 28 alloimmunization alloimmunization NN cord-010092-uftc8inx 12109 29 , , , cord-010092-uftc8inx 12109 30 and and CC cord-010092-uftc8inx 12109 31 transmission transmission NN cord-010092-uftc8inx 12109 32 of of IN cord-010092-uftc8inx 12109 33 leukotropic leukotropic JJ cord-010092-uftc8inx 12109 34 viruses virus NNS cord-010092-uftc8inx 12109 35 . . . cord-010092-uftc8inx 12110 1 Aims aim VBZ cord-010092-uftc8inx 12110 2 : : : cord-010092-uftc8inx 12111 1 The the DT cord-010092-uftc8inx 12111 2 goal goal NN cord-010092-uftc8inx 12111 3 was be VBD cord-010092-uftc8inx 12111 4 to to TO cord-010092-uftc8inx 12111 5 evaluate evaluate VB cord-010092-uftc8inx 12111 6 whether whether IN cord-010092-uftc8inx 12111 7 the the DT cord-010092-uftc8inx 12111 8 new new JJ cord-010092-uftc8inx 12111 9 domestic domestic JJ cord-010092-uftc8inx 12111 10 blood blood NN cord-010092-uftc8inx 12111 11 filter filter NN cord-010092-uftc8inx 12111 12 FINECELL FINECELL NNP cord-010092-uftc8inx 12111 13 , , , cord-010092-uftc8inx 12111 14 developed develop VBN cord-010092-uftc8inx 12111 15 by by IN cord-010092-uftc8inx 12111 16 KOLON KOLON NNP cord-010092-uftc8inx 12111 17 INDUSTRIES INDUSTRIES NNP cord-010092-uftc8inx 12111 18 , , , cord-010092-uftc8inx 12111 19 Gumi Gumi NNP cord-010092-uftc8inx 12111 20 , , , cord-010092-uftc8inx 12111 21 Korea Korea NNP cord-010092-uftc8inx 12111 22 , , , cord-010092-uftc8inx 12111 23 is be VBZ cord-010092-uftc8inx 12111 24 appropriately appropriately RB cord-010092-uftc8inx 12111 25 suited suited JJ cord-010092-uftc8inx 12111 26 to to IN cord-010092-uftc8inx 12111 27 the the DT cord-010092-uftc8inx 12111 28 international international JJ cord-010092-uftc8inx 12111 29 standards standard NNS cord-010092-uftc8inx 12111 30 . . . cord-010092-uftc8inx 12112 1 And and CC cord-010092-uftc8inx 12112 2 to to TO cord-010092-uftc8inx 12112 3 reveal reveal VB cord-010092-uftc8inx 12112 4 its -PRON- PRP$ cord-010092-uftc8inx 12112 5 efficacy efficacy NN cord-010092-uftc8inx 12112 6 and and CC cord-010092-uftc8inx 12112 7 safety safety NN cord-010092-uftc8inx 12112 8 in in IN cord-010092-uftc8inx 12112 9 the the DT cord-010092-uftc8inx 12112 10 settlement settlement NN cord-010092-uftc8inx 12112 11 of of IN cord-010092-uftc8inx 12112 12 leukocyte leukocyte NN cord-010092-uftc8inx 12112 13 reduction reduction NN cord-010092-uftc8inx 12112 14 system system NN cord-010092-uftc8inx 12112 15 in in IN cord-010092-uftc8inx 12112 16 Korea Korea NNP cord-010092-uftc8inx 12112 17 . . . cord-010092-uftc8inx 12113 1 Methods method NNS cord-010092-uftc8inx 12113 2 : : : cord-010092-uftc8inx 12114 1 Thirty thirty CD cord-010092-uftc8inx 12114 2 - - HYPH cord-010092-uftc8inx 12114 3 two two CD cord-010092-uftc8inx 12114 4 units unit NNS cord-010092-uftc8inx 12114 5 of of IN cord-010092-uftc8inx 12114 6 packed packed JJ cord-010092-uftc8inx 12114 7 red red JJ cord-010092-uftc8inx 12114 8 blood blood NN cord-010092-uftc8inx 12114 9 cells cell NNS cord-010092-uftc8inx 12114 10 obtained obtain VBN cord-010092-uftc8inx 12114 11 from from IN cord-010092-uftc8inx 12114 12 400 400 CD cord-010092-uftc8inx 12114 13 mL ml NN cord-010092-uftc8inx 12114 14 whole whole JJ cord-010092-uftc8inx 12114 15 blood blood NN cord-010092-uftc8inx 12114 16 collected collect VBN cord-010092-uftc8inx 12114 17 from from IN cord-010092-uftc8inx 12114 18 32 32 CD cord-010092-uftc8inx 12114 19 healthy healthy JJ cord-010092-uftc8inx 12114 20 donors donor NNS cord-010092-uftc8inx 12114 21 were be VBD cord-010092-uftc8inx 12114 22 used use VBN cord-010092-uftc8inx 12114 23 . . . cord-010092-uftc8inx 12115 1 This this DT cord-010092-uftc8inx 12115 2 was be VBD cord-010092-uftc8inx 12115 3 done do VBN cord-010092-uftc8inx 12115 4 by by IN cord-010092-uftc8inx 12115 5 analyzing analyze VBG cord-010092-uftc8inx 12115 6 the the DT cord-010092-uftc8inx 12115 7 filtration filtration NN cord-010092-uftc8inx 12115 8 time time NN cord-010092-uftc8inx 12115 9 , , , cord-010092-uftc8inx 12115 10 residual residual JJ cord-010092-uftc8inx 12115 11 leukocyte leukocyte NN cord-010092-uftc8inx 12115 12 count count NN cord-010092-uftc8inx 12115 13 , , , cord-010092-uftc8inx 12115 14 RBC RBC NNP cord-010092-uftc8inx 12115 15 recovery recovery NN cord-010092-uftc8inx 12115 16 , , , cord-010092-uftc8inx 12115 17 and and CC cord-010092-uftc8inx 12115 18 hemolysis hemolysis NN cord-010092-uftc8inx 12115 19 rate rate NN cord-010092-uftc8inx 12115 20 during during IN cord-010092-uftc8inx 12115 21 a a DT cord-010092-uftc8inx 12115 22 storage storage NN cord-010092-uftc8inx 12115 23 period period NN cord-010092-uftc8inx 12115 24 of of IN cord-010092-uftc8inx 12115 25 35 35 CD cord-010092-uftc8inx 12115 26 days day NNS cord-010092-uftc8inx 12115 27 after after IN cord-010092-uftc8inx 12115 28 leukoreduction leukoreduction NN cord-010092-uftc8inx 12115 29 . . . cord-010092-uftc8inx 12116 1 Results result NNS cord-010092-uftc8inx 12116 2 : : : cord-010092-uftc8inx 12117 1 The the DT cord-010092-uftc8inx 12117 2 standards standard NNS cord-010092-uftc8inx 12117 3 commonly commonly RB cord-010092-uftc8inx 12117 4 used use VBN cord-010092-uftc8inx 12117 5 for for IN cord-010092-uftc8inx 12117 6 the the DT cord-010092-uftc8inx 12117 7 evaluation evaluation NN cord-010092-uftc8inx 12117 8 of of IN cord-010092-uftc8inx 12117 9 leukocyte leukocyte NN cord-010092-uftc8inx 12117 10 - - HYPH cord-010092-uftc8inx 12117 11 removing remove VBG cord-010092-uftc8inx 12117 12 filters filter NNS cord-010092-uftc8inx 12117 13 are be VBP cord-010092-uftc8inx 12117 14 set set VBN cord-010092-uftc8inx 12117 15 by by IN cord-010092-uftc8inx 12117 16 the the DT cord-010092-uftc8inx 12117 17 Food Food NNP cord-010092-uftc8inx 12117 18 and and CC cord-010092-uftc8inx 12117 19 Drug Drug NNP cord-010092-uftc8inx 12117 20 Administration Administration NNP cord-010092-uftc8inx 12117 21 of of IN cord-010092-uftc8inx 12117 22 the the DT cord-010092-uftc8inx 12117 23 USA USA NNP cord-010092-uftc8inx 12117 24 and and CC cord-010092-uftc8inx 12117 25 the the DT cord-010092-uftc8inx 12117 26 Council Council NNP cord-010092-uftc8inx 12117 27 of of IN cord-010092-uftc8inx 12117 28 Europe Europe NNP cord-010092-uftc8inx 12117 29 . . . cord-010092-uftc8inx 12118 1 The the DT cord-010092-uftc8inx 12118 2 results result NNS cord-010092-uftc8inx 12118 3 of of IN cord-010092-uftc8inx 12118 4 our -PRON- PRP$ cord-010092-uftc8inx 12118 5 study study NN cord-010092-uftc8inx 12118 6 satisfied satisfy VBD cord-010092-uftc8inx 12118 7 these these DT cord-010092-uftc8inx 12118 8 international international JJ cord-010092-uftc8inx 12118 9 standards standard NNS cord-010092-uftc8inx 12118 10 . . . cord-010092-uftc8inx 12119 1 Summary Summary NNP cord-010092-uftc8inx 12119 2 / / SYM cord-010092-uftc8inx 12119 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 12119 4 : : : cord-010092-uftc8inx 12120 1 The the DT cord-010092-uftc8inx 12120 2 newly newly RB cord-010092-uftc8inx 12120 3 developed develop VBN cord-010092-uftc8inx 12120 4 domestic domestic JJ cord-010092-uftc8inx 12120 5 leukoreduction leukoreduction NN cord-010092-uftc8inx 12120 6 filter filter NN cord-010092-uftc8inx 12120 7 was be VBD cord-010092-uftc8inx 12120 8 , , , cord-010092-uftc8inx 12120 9 thus thus RB cord-010092-uftc8inx 12120 10 , , , cord-010092-uftc8inx 12120 11 found find VBN cord-010092-uftc8inx 12120 12 to to TO cord-010092-uftc8inx 12120 13 be be VB cord-010092-uftc8inx 12120 14 efficient efficient JJ cord-010092-uftc8inx 12120 15 and and CC cord-010092-uftc8inx 12120 16 will will MD cord-010092-uftc8inx 12120 17 contribute contribute VB cord-010092-uftc8inx 12120 18 to to IN cord-010092-uftc8inx 12120 19 the the DT cord-010092-uftc8inx 12120 20 improvement improvement NN cord-010092-uftc8inx 12120 21 of of IN cord-010092-uftc8inx 12120 22 the the DT cord-010092-uftc8inx 12120 23 quality quality NN cord-010092-uftc8inx 12120 24 of of IN cord-010092-uftc8inx 12120 25 isolated isolate VBN cord-010092-uftc8inx 12120 26 blood blood NN cord-010092-uftc8inx 12120 27 components component NNS cord-010092-uftc8inx 12120 28 used use VBN cord-010092-uftc8inx 12120 29 in in IN cord-010092-uftc8inx 12120 30 Korea Korea NNP cord-010092-uftc8inx 12120 31 . . . cord-010092-uftc8inx 12121 1 Faculty Faculty NNP cord-010092-uftc8inx 12121 2 of of IN cord-010092-uftc8inx 12121 3 Science Science NNP cord-010092-uftc8inx 12121 4 , , , cord-010092-uftc8inx 12121 5 Humanities Humanities NNP cord-010092-uftc8inx 12121 6 and and CC cord-010092-uftc8inx 12121 7 Education Education NNP cord-010092-uftc8inx 12121 8 , , , cord-010092-uftc8inx 12121 9 Technical Technical NNP cord-010092-uftc8inx 12121 10 University University NNP cord-010092-uftc8inx 12121 11 of of IN cord-010092-uftc8inx 12121 12 Liberec Liberec NNP cord-010092-uftc8inx 12121 13 , , , cord-010092-uftc8inx 12121 14 Liberec Liberec NNP cord-010092-uftc8inx 12121 15 , , , cord-010092-uftc8inx 12121 16 Czech Czech NNP cord-010092-uftc8inx 12121 17 Republic Republic NNP cord-010092-uftc8inx 12121 18 Background Background NNP cord-010092-uftc8inx 12121 19 : : : cord-010092-uftc8inx 12122 1 As as IN cord-010092-uftc8inx 12122 2 polymeric polymeric JJ cord-010092-uftc8inx 12122 3 fibrous fibrous JJ cord-010092-uftc8inx 12122 4 scaffold scaffold NN cord-010092-uftc8inx 12122 5 fabrication fabrication NN cord-010092-uftc8inx 12122 6 techniques technique NNS cord-010092-uftc8inx 12122 7 strive strive VBP cord-010092-uftc8inx 12122 8 to to TO cord-010092-uftc8inx 12122 9 create create VB cord-010092-uftc8inx 12122 10 structures structure NNS cord-010092-uftc8inx 12122 11 that that WDT cord-010092-uftc8inx 12122 12 more more RBR cord-010092-uftc8inx 12122 13 closely closely RB cord-010092-uftc8inx 12122 14 replicate replicate VB cord-010092-uftc8inx 12122 15 tentative tentative JJ cord-010092-uftc8inx 12122 16 extracellular extracellular JJ cord-010092-uftc8inx 12122 17 matrix matrix NN cord-010092-uftc8inx 12122 18 form form NN cord-010092-uftc8inx 12122 19 and and CC cord-010092-uftc8inx 12122 20 function function NN cord-010092-uftc8inx 12122 21 , , , cord-010092-uftc8inx 12122 22 the the DT cord-010092-uftc8inx 12122 23 need need NN cord-010092-uftc8inx 12122 24 for for IN cord-010092-uftc8inx 12122 25 increased increase VBN cord-010092-uftc8inx 12122 26 scaffold scaffold NN cord-010092-uftc8inx 12122 27 bioactivity bioactivity NN cord-010092-uftc8inx 12122 28 becomes become VBZ cord-010092-uftc8inx 12122 29 more more RBR cord-010092-uftc8inx 12122 30 pronounced pronounced JJ cord-010092-uftc8inx 12122 31 . . . cord-010092-uftc8inx 12123 1 The the DT cord-010092-uftc8inx 12123 2 fibrous fibrous JJ cord-010092-uftc8inx 12123 3 structure structure NN cord-010092-uftc8inx 12123 4 made make VBN cord-010092-uftc8inx 12123 5 from from IN cord-010092-uftc8inx 12123 6 biocompatible biocompatible JJ cord-010092-uftc8inx 12123 7 and and CC cord-010092-uftc8inx 12123 8 nontoxic nontoxic JJ cord-010092-uftc8inx 12123 9 polymers polymer NNS cord-010092-uftc8inx 12123 10 ensures ensure VBZ cord-010092-uftc8inx 12123 11 mechanical mechanical JJ cord-010092-uftc8inx 12123 12 stability stability NN cord-010092-uftc8inx 12123 13 , , , cord-010092-uftc8inx 12123 14 however however RB cord-010092-uftc8inx 12123 15 cell cell NN cord-010092-uftc8inx 12123 16 proliferation proliferation NN cord-010092-uftc8inx 12123 17 requires require VBZ cord-010092-uftc8inx 12123 18 further further JJ cord-010092-uftc8inx 12123 19 stimulation stimulation NN cord-010092-uftc8inx 12123 20 . . . cord-010092-uftc8inx 12124 1 Platelet platelet NN cord-010092-uftc8inx 12124 2 - - HYPH cord-010092-uftc8inx 12124 3 rich rich JJ cord-010092-uftc8inx 12124 4 plasma plasma NN cord-010092-uftc8inx 12124 5 , , , cord-010092-uftc8inx 12124 6 which which WDT cord-010092-uftc8inx 12124 7 has have VBZ cord-010092-uftc8inx 12124 8 been be VBN cord-010092-uftc8inx 12124 9 shown show VBN cord-010092-uftc8inx 12124 10 to to TO cord-010092-uftc8inx 12124 11 contain contain VB cord-010092-uftc8inx 12124 12 over over IN cord-010092-uftc8inx 12124 13 300 300 CD cord-010092-uftc8inx 12124 14 bioactive bioactive JJ cord-010092-uftc8inx 12124 15 molecules molecule NNS cord-010092-uftc8inx 12124 16 , , , cord-010092-uftc8inx 12124 17 has have VBZ cord-010092-uftc8inx 12124 18 the the DT cord-010092-uftc8inx 12124 19 potential potential NN cord-010092-uftc8inx 12124 20 to to TO cord-010092-uftc8inx 12124 21 deliver deliver VB cord-010092-uftc8inx 12124 22 a a DT cord-010092-uftc8inx 12124 23 combination combination NN cord-010092-uftc8inx 12124 24 of of IN cord-010092-uftc8inx 12124 25 growth growth NN cord-010092-uftc8inx 12124 26 factors factor NNS cord-010092-uftc8inx 12124 27 ( ( -LRB- cord-010092-uftc8inx 12124 28 GFs gf NNS cord-010092-uftc8inx 12124 29 ) ) -RRB- cord-010092-uftc8inx 12124 30 and and CC cord-010092-uftc8inx 12124 31 cytokines cytokine NNS cord-010092-uftc8inx 12124 32 capable capable JJ cord-010092-uftc8inx 12124 33 of of IN cord-010092-uftc8inx 12124 34 stimulating stimulate VBG cord-010092-uftc8inx 12124 35 cellular cellular JJ cord-010092-uftc8inx 12124 36 activity activity NN cord-010092-uftc8inx 12124 37 . . . cord-010092-uftc8inx 12125 1 Aims aim VBZ cord-010092-uftc8inx 12125 2 : : : cord-010092-uftc8inx 12126 1 The the DT cord-010092-uftc8inx 12126 2 presented present VBN cord-010092-uftc8inx 12126 3 work work NN cord-010092-uftc8inx 12126 4 deals deal NNS cord-010092-uftc8inx 12126 5 with with IN cord-010092-uftc8inx 12126 6 the the DT cord-010092-uftc8inx 12126 7 preparation preparation NN cord-010092-uftc8inx 12126 8 of of IN cord-010092-uftc8inx 12126 9 nanofibrous nanofibrous JJ cord-010092-uftc8inx 12126 10 materials material NNS cord-010092-uftc8inx 12126 11 with with IN cord-010092-uftc8inx 12126 12 platelet platelet NN cord-010092-uftc8inx 12126 13 growth growth NN cord-010092-uftc8inx 12126 14 factors factor NNS cord-010092-uftc8inx 12126 15 incorporated incorporate VBN cord-010092-uftc8inx 12126 16 into into IN cord-010092-uftc8inx 12126 17 the the DT cord-010092-uftc8inx 12126 18 internal internal JJ cord-010092-uftc8inx 12126 19 fiber fiber NN cord-010092-uftc8inx 12126 20 structure structure NN cord-010092-uftc8inx 12126 21 . . . cord-010092-uftc8inx 12127 1 Polyvinyl polyvinyl NN cord-010092-uftc8inx 12127 2 alcohol alcohol NN cord-010092-uftc8inx 12127 3 ( ( -LRB- cord-010092-uftc8inx 12127 4 PVA PVA NNP cord-010092-uftc8inx 12127 5 ) ) -RRB- cord-010092-uftc8inx 12127 6 was be VBD cord-010092-uftc8inx 12127 7 used use VBN cord-010092-uftc8inx 12127 8 for for IN cord-010092-uftc8inx 12127 9 the the DT cord-010092-uftc8inx 12127 10 preparation preparation NN cord-010092-uftc8inx 12127 11 a a DT cord-010092-uftc8inx 12127 12 material material NN cord-010092-uftc8inx 12127 13 providing provide VBG cord-010092-uftc8inx 12127 14 a a DT cord-010092-uftc8inx 12127 15 progressive progressive JJ cord-010092-uftc8inx 12127 16 release release NN cord-010092-uftc8inx 12127 17 of of IN cord-010092-uftc8inx 12127 18 native native JJ cord-010092-uftc8inx 12127 19 GFs gf NNS cord-010092-uftc8inx 12127 20 without without IN cord-010092-uftc8inx 12127 21 need need NN cord-010092-uftc8inx 12127 22 of of IN cord-010092-uftc8inx 12127 23 subsequent subsequent JJ cord-010092-uftc8inx 12127 24 crosslinking crosslinking NN cord-010092-uftc8inx 12127 25 . . . cord-010092-uftc8inx 12128 1 Methods method NNS cord-010092-uftc8inx 12128 2 : : : cord-010092-uftc8inx 12129 1 Materials material NNS cord-010092-uftc8inx 12129 2 were be VBD cord-010092-uftc8inx 12129 3 prepared prepare VBN cord-010092-uftc8inx 12129 4 from from IN cord-010092-uftc8inx 12129 5 PVA PVA NNP cord-010092-uftc8inx 12129 6 ( ( -LRB- cord-010092-uftc8inx 12129 7 Mw Mw NNP cord-010092-uftc8inx 12129 8 125,000 125,000 CD cord-010092-uftc8inx 12129 9 , , , cord-010092-uftc8inx 12129 10 98 98 CD cord-010092-uftc8inx 12129 11 % % NN cord-010092-uftc8inx 12129 12 of of IN cord-010092-uftc8inx 12129 13 hydrolysis hydrolysis NN cord-010092-uftc8inx 12129 14 ) ) -RRB- cord-010092-uftc8inx 12129 15 using use VBG cord-010092-uftc8inx 12129 16 electrospinning electrospinning NN cord-010092-uftc8inx 12129 17 technology technology NN cord-010092-uftc8inx 12129 18 ( ( -LRB- cord-010092-uftc8inx 12129 19 Nanospider Nanospider NNP cord-010092-uftc8inx 12129 20 TM TM NNP cord-010092-uftc8inx 12129 21 1WS500U 1ws500u CD cord-010092-uftc8inx 12129 22 ) ) -RRB- cord-010092-uftc8inx 12129 23 . . . cord-010092-uftc8inx 12130 1 Platelet platelet NN cord-010092-uftc8inx 12130 2 lysate lysate NN cord-010092-uftc8inx 12130 3 ( ( -LRB- cord-010092-uftc8inx 12130 4 PL pl NN cord-010092-uftc8inx 12130 5 ) ) -RRB- cord-010092-uftc8inx 12130 6 was be VBD cord-010092-uftc8inx 12130 7 prepared prepare VBN cord-010092-uftc8inx 12130 8 from from IN cord-010092-uftc8inx 12130 9 thrombocyte thrombocyte NNP cord-010092-uftc8inx 12130 10 rich rich JJ cord-010092-uftc8inx 12130 11 solution solution NN cord-010092-uftc8inx 12130 12 ( ( -LRB- cord-010092-uftc8inx 12130 13 obtained obtain VBN cord-010092-uftc8inx 12130 14 from from IN cord-010092-uftc8inx 12130 15 regional regional JJ cord-010092-uftc8inx 12130 16 hospital hospital NN cord-010092-uftc8inx 12130 17 in in IN cord-010092-uftc8inx 12130 18 Liberec Liberec NNP cord-010092-uftc8inx 12130 19 , , , cord-010092-uftc8inx 12130 20 the the DT cord-010092-uftc8inx 12130 21 concentration concentration NN cord-010092-uftc8inx 12130 22 of of IN cord-010092-uftc8inx 12130 23 700 700 CD cord-010092-uftc8inx 12130 24 - - SYM cord-010092-uftc8inx 12130 25 900 900 CD cord-010092-uftc8inx 12130 26 x10 x10 CD cord-010092-uftc8inx 12130 27 6 6 CD cord-010092-uftc8inx 12130 28 PLT PLT NNP cord-010092-uftc8inx 12130 29 / / SYM cord-010092-uftc8inx 12130 30 ml ml NN cord-010092-uftc8inx 12130 31 , , , cord-010092-uftc8inx 12130 32 freeze freeze NN cord-010092-uftc8inx 12130 33 - - HYPH cord-010092-uftc8inx 12130 34 thaw thaw NN cord-010092-uftc8inx 12130 35 method method NN cord-010092-uftc8inx 12130 36 with with IN cord-010092-uftc8inx 12130 37 subsequent subsequent JJ cord-010092-uftc8inx 12130 38 centrifugation centrifugation NN cord-010092-uftc8inx 12130 39 ) ) -RRB- cord-010092-uftc8inx 12130 40 . . . cord-010092-uftc8inx 12131 1 Nanofibers Nanofibers NNP cord-010092-uftc8inx 12131 2 were be VBD cord-010092-uftc8inx 12131 3 electrospun electrospun VBN cord-010092-uftc8inx 12131 4 from from IN cord-010092-uftc8inx 12131 5 10 10 CD cord-010092-uftc8inx 12131 6 % % NN cord-010092-uftc8inx 12131 7 PVA PVA NNP cord-010092-uftc8inx 12131 8 solution solution NN cord-010092-uftc8inx 12131 9 using use VBG cord-010092-uftc8inx 12131 10 water water NN cord-010092-uftc8inx 12131 11 : : : cord-010092-uftc8inx 12131 12 ethanol ethanol NN cord-010092-uftc8inx 12131 13 ( ( -LRB- cord-010092-uftc8inx 12131 14 8:2 8:2 CD cord-010092-uftc8inx 12131 15 ) ) -RRB- cord-010092-uftc8inx 12131 16 solvent solvent NN cord-010092-uftc8inx 12131 17 system system NN cord-010092-uftc8inx 12131 18 . . . cord-010092-uftc8inx 12132 1 Materials material NNS cord-010092-uftc8inx 12132 2 with with IN cord-010092-uftc8inx 12132 3 proteins protein NNS cord-010092-uftc8inx 12132 4 were be VBD cord-010092-uftc8inx 12132 5 electrospun electrospun VBN cord-010092-uftc8inx 12132 6 from from IN cord-010092-uftc8inx 12132 7 solution solution NN cord-010092-uftc8inx 12132 8 containing contain VBG cord-010092-uftc8inx 12132 9 10 10 CD cord-010092-uftc8inx 12132 10 % % NN cord-010092-uftc8inx 12132 11 of of IN cord-010092-uftc8inx 12132 12 PVA PVA NNP cord-010092-uftc8inx 12132 13 and and CC cord-010092-uftc8inx 12132 14 10 10 CD cord-010092-uftc8inx 12132 15 % % NN cord-010092-uftc8inx 12132 16 of of IN cord-010092-uftc8inx 12132 17 PL pl NN cord-010092-uftc8inx 12132 18 . . . cord-010092-uftc8inx 12133 1 Morphological morphological JJ cord-010092-uftc8inx 12133 2 analysis analysis NN cord-010092-uftc8inx 12133 3 was be VBD cord-010092-uftc8inx 12133 4 performed perform VBN cord-010092-uftc8inx 12133 5 by by IN cord-010092-uftc8inx 12133 6 scanning scan VBG cord-010092-uftc8inx 12133 7 electron electron NN cord-010092-uftc8inx 12133 8 microscopy microscopy NN cord-010092-uftc8inx 12133 9 . . . cord-010092-uftc8inx 12134 1 Protein protein NN cord-010092-uftc8inx 12134 2 release release NN cord-010092-uftc8inx 12134 3 was be VBD cord-010092-uftc8inx 12134 4 monitored monitor VBN cord-010092-uftc8inx 12134 5 using use VBG cord-010092-uftc8inx 12134 6 spectrophotometry spectrophotometry NN cord-010092-uftc8inx 12134 7 ( ( -LRB- cord-010092-uftc8inx 12134 8 Bradford Bradford NNP cord-010092-uftc8inx 12134 9 method method NN cord-010092-uftc8inx 12134 10 ) ) -RRB- cord-010092-uftc8inx 12134 11 and and CC cord-010092-uftc8inx 12134 12 chromatography chromatography NN cord-010092-uftc8inx 12134 13 . . . cord-010092-uftc8inx 12135 1 Results result NNS cord-010092-uftc8inx 12135 2 : : : cord-010092-uftc8inx 12136 1 The the DT cord-010092-uftc8inx 12136 2 prepared prepared JJ cord-010092-uftc8inx 12136 3 fibrous fibrous JJ cord-010092-uftc8inx 12136 4 materials material NNS cord-010092-uftc8inx 12136 5 consisted consist VBN cord-010092-uftc8inx 12136 6 of of IN cord-010092-uftc8inx 12136 7 random random JJ cord-010092-uftc8inx 12136 8 oriented oriented JJ cord-010092-uftc8inx 12136 9 end end NN cord-010092-uftc8inx 12136 10 - - HYPH cord-010092-uftc8inx 12136 11 less less JJR cord-010092-uftc8inx 12136 12 fiber fiber NN cord-010092-uftc8inx 12136 13 with with IN cord-010092-uftc8inx 12136 14 smooth smooth JJ cord-010092-uftc8inx 12136 15 surface surface NN cord-010092-uftc8inx 12136 16 with with IN cord-010092-uftc8inx 12136 17 minimal minimal JJ cord-010092-uftc8inx 12136 18 defects defect NNS cord-010092-uftc8inx 12136 19 in in IN cord-010092-uftc8inx 12136 20 structure structure NN cord-010092-uftc8inx 12136 21 . . . cord-010092-uftc8inx 12137 1 The the DT cord-010092-uftc8inx 12137 2 morphology morphology NN cord-010092-uftc8inx 12137 3 of of IN cord-010092-uftc8inx 12137 4 materials material NNS cord-010092-uftc8inx 12137 5 was be VBD cord-010092-uftc8inx 12137 6 not not RB cord-010092-uftc8inx 12137 7 altered alter VBN cord-010092-uftc8inx 12137 8 by by IN cord-010092-uftc8inx 12137 9 the the DT cord-010092-uftc8inx 12137 10 addition addition NN cord-010092-uftc8inx 12137 11 of of IN cord-010092-uftc8inx 12137 12 proteins protein NNS cord-010092-uftc8inx 12137 13 . . . cord-010092-uftc8inx 12138 1 The the DT cord-010092-uftc8inx 12138 2 average average JJ cord-010092-uftc8inx 12138 3 fiber fiber NN cord-010092-uftc8inx 12138 4 diameter diameter NN cord-010092-uftc8inx 12138 5 was be VBD cord-010092-uftc8inx 12138 6 : : : cord-010092-uftc8inx 12138 7 340 340 CD cord-010092-uftc8inx 12138 8 AE AE NNP cord-010092-uftc8inx 12138 9 120 120 CD cord-010092-uftc8inx 12138 10 nm nm NN cord-010092-uftc8inx 12138 11 for for IN cord-010092-uftc8inx 12138 12 pristine pristine JJ cord-010092-uftc8inx 12138 13 PVA PVA NNP cord-010092-uftc8inx 12138 14 fibers fiber NNS cord-010092-uftc8inx 12138 15 and and CC cord-010092-uftc8inx 12138 16 350 350 CD cord-010092-uftc8inx 12138 17 AE AE NNP cord-010092-uftc8inx 12138 18 148 148 CD cord-010092-uftc8inx 12138 19 nm nm NN cord-010092-uftc8inx 12138 20 for for IN cord-010092-uftc8inx 12138 21 PVA PVA NNP cord-010092-uftc8inx 12138 22 with with IN cord-010092-uftc8inx 12138 23 incorporated incorporate VBN cord-010092-uftc8inx 12138 24 proteins protein NNS cord-010092-uftc8inx 12138 25 ( ( -LRB- cord-010092-uftc8inx 12138 26 PVA PVA NNP cord-010092-uftc8inx 12138 27 / / SYM cord-010092-uftc8inx 12138 28 PL PL NNP cord-010092-uftc8inx 12138 29 ) ) -RRB- cord-010092-uftc8inx 12138 30 . . . cord-010092-uftc8inx 12139 1 PVA PVA NNP cord-010092-uftc8inx 12139 2 / / SYM cord-010092-uftc8inx 12139 3 PL PL NNP cord-010092-uftc8inx 12139 4 layers layer NNS cord-010092-uftc8inx 12139 5 contain contain VBP cord-010092-uftc8inx 12139 6 5 5 CD cord-010092-uftc8inx 12139 7 - - SYM cord-010092-uftc8inx 12139 8 10 10 CD cord-010092-uftc8inx 12139 9 mg mg NN cord-010092-uftc8inx 12139 10 of of IN cord-010092-uftc8inx 12139 11 protein protein NN cord-010092-uftc8inx 12139 12 per per IN cord-010092-uftc8inx 12139 13 gram gram NN cord-010092-uftc8inx 12139 14 of of IN cord-010092-uftc8inx 12139 15 PVA PVA NNP cord-010092-uftc8inx 12139 16 . . . cord-010092-uftc8inx 12140 1 60 60 CD cord-010092-uftc8inx 12140 2 % % NN cord-010092-uftc8inx 12140 3 of of IN cord-010092-uftc8inx 12140 4 the the DT cord-010092-uftc8inx 12140 5 proteins protein NNS cord-010092-uftc8inx 12140 6 are be VBP cord-010092-uftc8inx 12140 7 released release VBN cord-010092-uftc8inx 12140 8 during during IN cord-010092-uftc8inx 12140 9 the the DT cord-010092-uftc8inx 12140 10 first first JJ cord-010092-uftc8inx 12140 11 day day NN cord-010092-uftc8inx 12140 12 ( ( -LRB- cord-010092-uftc8inx 12140 13 burst burst NN cord-010092-uftc8inx 12140 14 release release NN cord-010092-uftc8inx 12140 15 ) ) -RRB- cord-010092-uftc8inx 12140 16 followed follow VBN cord-010092-uftc8inx 12140 17 by by IN cord-010092-uftc8inx 12140 18 a a DT cord-010092-uftc8inx 12140 19 gradual gradual JJ cord-010092-uftc8inx 12140 20 release release NN cord-010092-uftc8inx 12140 21 of of IN cord-010092-uftc8inx 12140 22 up up IN cord-010092-uftc8inx 12140 23 to to TO cord-010092-uftc8inx 12140 24 2 2 CD cord-010092-uftc8inx 12140 25 weeks week NNS cord-010092-uftc8inx 12140 26 . . . cord-010092-uftc8inx 12141 1 Summary Summary NNP cord-010092-uftc8inx 12141 2 / / SYM cord-010092-uftc8inx 12141 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 12141 4 : : : cord-010092-uftc8inx 12142 1 Nanofibrous Nanofibrous NNP cord-010092-uftc8inx 12142 2 PVA PVA NNP cord-010092-uftc8inx 12142 3 - - HYPH cord-010092-uftc8inx 12142 4 based base VBN cord-010092-uftc8inx 12142 5 nanofiber nanofiber NN cord-010092-uftc8inx 12142 6 materials material NNS cord-010092-uftc8inx 12142 7 were be VBD cord-010092-uftc8inx 12142 8 prepared prepare VBN cord-010092-uftc8inx 12142 9 with with IN cord-010092-uftc8inx 12142 10 native native JJ cord-010092-uftc8inx 12142 11 growth growth NN cord-010092-uftc8inx 12142 12 factors factor NNS cord-010092-uftc8inx 12142 13 . . . cord-010092-uftc8inx 12143 1 The the DT cord-010092-uftc8inx 12143 2 process process NN cord-010092-uftc8inx 12143 3 used use VBN cord-010092-uftc8inx 12143 4 for for IN cord-010092-uftc8inx 12143 5 the the DT cord-010092-uftc8inx 12143 6 preparation preparation NN cord-010092-uftc8inx 12143 7 of of IN cord-010092-uftc8inx 12143 8 solutions solution NNS cord-010092-uftc8inx 12143 9 and and CC cord-010092-uftc8inx 12143 10 subsequent subsequent JJ cord-010092-uftc8inx 12143 11 spinning spinning NN cord-010092-uftc8inx 12143 12 does do VBZ cord-010092-uftc8inx 12143 13 not not RB cord-010092-uftc8inx 12143 14 affect affect VB cord-010092-uftc8inx 12143 15 the the DT cord-010092-uftc8inx 12143 16 activity activity NN cord-010092-uftc8inx 12143 17 of of IN cord-010092-uftc8inx 12143 18 the the DT cord-010092-uftc8inx 12143 19 incorporated incorporate VBN cord-010092-uftc8inx 12143 20 proteins protein NNS cord-010092-uftc8inx 12143 21 , , , cord-010092-uftc8inx 12143 22 which which WDT cord-010092-uftc8inx 12143 23 are be VBP cord-010092-uftc8inx 12143 24 being be VBG cord-010092-uftc8inx 12143 25 gradually gradually RB cord-010092-uftc8inx 12143 26 released release VBN cord-010092-uftc8inx 12143 27 . . . cord-010092-uftc8inx 12144 1 Therefore therefore RB cord-010092-uftc8inx 12144 2 , , , cord-010092-uftc8inx 12144 3 we -PRON- PRP cord-010092-uftc8inx 12144 4 believe believe VBP cord-010092-uftc8inx 12144 5 that that IN cord-010092-uftc8inx 12144 6 the the DT cord-010092-uftc8inx 12144 7 developed develop VBN cord-010092-uftc8inx 12144 8 material material NN cord-010092-uftc8inx 12144 9 has have VBZ cord-010092-uftc8inx 12144 10 great great JJ cord-010092-uftc8inx 12144 11 potential potential NN cord-010092-uftc8inx 12144 12 for for IN cord-010092-uftc8inx 12144 13 use use NN cord-010092-uftc8inx 12144 14 in in IN cord-010092-uftc8inx 12144 15 tissue tissue NN cord-010092-uftc8inx 12144 16 engineering engineering NN cord-010092-uftc8inx 12145 1 e.g. e.g. RB cord-010092-uftc8inx 12145 2 to to TO cord-010092-uftc8inx 12145 3 promote promote VB cord-010092-uftc8inx 12145 4 healing healing NN cord-010092-uftc8inx 12145 5 of of IN cord-010092-uftc8inx 12145 6 chronic chronic JJ cord-010092-uftc8inx 12145 7 wounds wound NNS cord-010092-uftc8inx 12145 8 . . . cord-010092-uftc8inx 12146 1 Acknowledgements acknowledgement NNS cord-010092-uftc8inx 12146 2 : : : cord-010092-uftc8inx 12147 1 Supported support VBN cord-010092-uftc8inx 12147 2 by by IN cord-010092-uftc8inx 12147 3 the the DT cord-010092-uftc8inx 12147 4 Czech Czech NNP cord-010092-uftc8inx 12147 5 Health Health NNP cord-010092-uftc8inx 12147 6 Research Research NNP cord-010092-uftc8inx 12147 7 Council Council NNP cord-010092-uftc8inx 12147 8 , , , cord-010092-uftc8inx 12147 9 project project NN cord-010092-uftc8inx 12148 1 No no DT cord-010092-uftc8inx 12148 2 NV18 NV18 NNP cord-010092-uftc8inx 12148 3 - - HYPH cord-010092-uftc8inx 12148 4 01 01 CD cord-010092-uftc8inx 12148 5 - - HYPH cord-010092-uftc8inx 12148 6 00332 00332 CD cord-010092-uftc8inx 12148 7 . . . cord-010092-uftc8inx 12149 1 Background background NN cord-010092-uftc8inx 12149 2 : : : cord-010092-uftc8inx 12150 1 Human human JJ cord-010092-uftc8inx 12150 2 a a NN cord-010092-uftc8inx 12150 3 - - HYPH cord-010092-uftc8inx 12150 4 defensins defensin NNS cord-010092-uftc8inx 12150 5 are be VBP cord-010092-uftc8inx 12150 6 small small JJ cord-010092-uftc8inx 12150 7 cationic cationic JJ cord-010092-uftc8inx 12150 8 peptides peptide NNS cord-010092-uftc8inx 12150 9 with with IN cord-010092-uftc8inx 12150 10 antimicrobial antimicrobial JJ cord-010092-uftc8inx 12150 11 and and CC cord-010092-uftc8inx 12150 12 anticancer anticancer JJ cord-010092-uftc8inx 12150 13 activity activity NN cord-010092-uftc8inx 12150 14 . . . cord-010092-uftc8inx 12151 1 Up up IN cord-010092-uftc8inx 12151 2 till till IN cord-010092-uftc8inx 12151 3 now now RB cord-010092-uftc8inx 12151 4 , , , cord-010092-uftc8inx 12151 5 six six CD cord-010092-uftc8inx 12151 6 a a DT cord-010092-uftc8inx 12151 7 - - HYPH cord-010092-uftc8inx 12151 8 defensins defensin NNS cord-010092-uftc8inx 12151 9 have have VBP cord-010092-uftc8inx 12151 10 been be VBN cord-010092-uftc8inx 12151 11 described describe VBN cord-010092-uftc8inx 12151 12 in in IN cord-010092-uftc8inx 12151 13 humans human NNS cord-010092-uftc8inx 12151 14 . . . cord-010092-uftc8inx 12152 1 They -PRON- PRP cord-010092-uftc8inx 12152 2 include include VBP cord-010092-uftc8inx 12152 3 the the DT cord-010092-uftc8inx 12152 4 human human JJ cord-010092-uftc8inx 12152 5 neutrophil neutrophil NN cord-010092-uftc8inx 12152 6 peptides peptide NNS cord-010092-uftc8inx 12152 7 ( ( -LRB- cord-010092-uftc8inx 12152 8 HNP HNP NNP cord-010092-uftc8inx 12152 9 ) ) -RRB- cord-010092-uftc8inx 12152 10 1 1 CD cord-010092-uftc8inx 12152 11 , , , cord-010092-uftc8inx 12152 12 2 2 CD cord-010092-uftc8inx 12152 13 and and CC cord-010092-uftc8inx 12152 14 3 3 CD cord-010092-uftc8inx 12152 15 which which WDT cord-010092-uftc8inx 12152 16 present present JJ cord-010092-uftc8inx 12152 17 in in IN cord-010092-uftc8inx 12152 18 large large JJ cord-010092-uftc8inx 12152 19 amounts amount NNS cord-010092-uftc8inx 12152 20 in in IN cord-010092-uftc8inx 12152 21 neutrophil neutrophil NN cord-010092-uftc8inx 12152 22 azurophilic azurophilic JJ cord-010092-uftc8inx 12152 23 granules granule NNS cord-010092-uftc8inx 12152 24 and and CC cord-010092-uftc8inx 12152 25 differed differ VBD cord-010092-uftc8inx 12152 26 from from IN cord-010092-uftc8inx 12152 27 each each DT cord-010092-uftc8inx 12152 28 other other JJ cord-010092-uftc8inx 12152 29 only only RB cord-010092-uftc8inx 12152 30 in in IN cord-010092-uftc8inx 12152 31 the the DT cord-010092-uftc8inx 12152 32 first first JJ cord-010092-uftc8inx 12152 33 amino amino NN cord-010092-uftc8inx 12152 34 acid acid NN cord-010092-uftc8inx 12152 35 . . . cord-010092-uftc8inx 12153 1 A a DT cord-010092-uftc8inx 12153 2 fourth fourth JJ cord-010092-uftc8inx 12153 3 defensin defensin NNS cord-010092-uftc8inx 12153 4 , , , cord-010092-uftc8inx 12153 5 termed term VBD cord-010092-uftc8inx 12153 6 HNP-4 HNP-4 NNP cord-010092-uftc8inx 12153 7 , , , cord-010092-uftc8inx 12153 8 comprises comprise VBZ cord-010092-uftc8inx 12153 9 less less JJR cord-010092-uftc8inx 12153 10 than than IN cord-010092-uftc8inx 12153 11 1 1 CD cord-010092-uftc8inx 12153 12 % % NN cord-010092-uftc8inx 12153 13 of of IN cord-010092-uftc8inx 12153 14 the the DT cord-010092-uftc8inx 12153 15 total total JJ cord-010092-uftc8inx 12153 16 defensins defensin NNS cord-010092-uftc8inx 12153 17 in in IN cord-010092-uftc8inx 12153 18 neutrophils neutrophil NNS cord-010092-uftc8inx 12153 19 and and CC cord-010092-uftc8inx 12153 20 has have VBZ cord-010092-uftc8inx 12153 21 a a DT cord-010092-uftc8inx 12153 22 distinct distinct JJ cord-010092-uftc8inx 12153 23 sequence sequence NN cord-010092-uftc8inx 12153 24 from from IN cord-010092-uftc8inx 12153 25 HNP1 HNP1 NNP cord-010092-uftc8inx 12153 26 - - HYPH cord-010092-uftc8inx 12153 27 3 3 CD cord-010092-uftc8inx 12153 28 . . . cord-010092-uftc8inx 12154 1 The the DT cord-010092-uftc8inx 12154 2 other other JJ cord-010092-uftc8inx 12154 3 two two CD cord-010092-uftc8inx 12154 4 , , , cord-010092-uftc8inx 12154 5 human human JJ cord-010092-uftc8inx 12154 6 defensin defensin NNP cord-010092-uftc8inx 12154 7 5 5 CD cord-010092-uftc8inx 12154 8 and and CC cord-010092-uftc8inx 12154 9 6 6 CD cord-010092-uftc8inx 12154 10 , , , cord-010092-uftc8inx 12154 11 are be VBP cord-010092-uftc8inx 12154 12 synthesized synthesize VBN cord-010092-uftc8inx 12154 13 mostly mostly RB cord-010092-uftc8inx 12154 14 by by IN cord-010092-uftc8inx 12154 15 intestinal intestinal JJ cord-010092-uftc8inx 12154 16 Paneth Paneth NNP cord-010092-uftc8inx 12154 17 cells cell NNS cord-010092-uftc8inx 12154 18 . . . cord-010092-uftc8inx 12155 1 Neutrophil Neutrophil NNP cord-010092-uftc8inx 12155 2 defensins defensin NNS cord-010092-uftc8inx 12155 3 ( ( -LRB- cord-010092-uftc8inx 12155 4 HNP HNP NNP cord-010092-uftc8inx 12155 5 1 1 CD cord-010092-uftc8inx 12155 6 - - SYM cord-010092-uftc8inx 12155 7 3 3 CD cord-010092-uftc8inx 12155 8 ) ) -RRB- cord-010092-uftc8inx 12155 9 are be VBP cord-010092-uftc8inx 12155 10 3.4 3.4 CD cord-010092-uftc8inx 12155 11 kDa kDa NNS cord-010092-uftc8inx 12155 12 peptides peptide NNS cord-010092-uftc8inx 12155 13 that that WDT cord-010092-uftc8inx 12155 14 are be VBP cord-010092-uftc8inx 12155 15 characterized characterize VBN cord-010092-uftc8inx 12155 16 by by IN cord-010092-uftc8inx 12155 17 three three CD cord-010092-uftc8inx 12155 18 disulfide disulfide NN cord-010092-uftc8inx 12155 19 bridges bridge NNS cord-010092-uftc8inx 12155 20 . . . cord-010092-uftc8inx 12156 1 The the DT cord-010092-uftc8inx 12156 2 pattern pattern NN cord-010092-uftc8inx 12156 3 of of IN cord-010092-uftc8inx 12156 4 disulfide disulfide JJ cord-010092-uftc8inx 12156 5 bonds bond NNS cord-010092-uftc8inx 12156 6 in in IN cord-010092-uftc8inx 12156 7 the the DT cord-010092-uftc8inx 12156 8 mature mature JJ cord-010092-uftc8inx 12156 9 forms form NNS cord-010092-uftc8inx 12156 10 is be VBZ cord-010092-uftc8inx 12156 11 crucial crucial JJ cord-010092-uftc8inx 12156 12 for for IN cord-010092-uftc8inx 12156 13 the the DT cord-010092-uftc8inx 12156 14 functional functional JJ cord-010092-uftc8inx 12156 15 properties property NNS cord-010092-uftc8inx 12156 16 . . . cord-010092-uftc8inx 12157 1 Due due IN cord-010092-uftc8inx 12157 2 to to IN cord-010092-uftc8inx 12157 3 this this DT cord-010092-uftc8inx 12157 4 structural structural JJ cord-010092-uftc8inx 12157 5 feature feature NN cord-010092-uftc8inx 12157 6 , , , cord-010092-uftc8inx 12157 7 synthesis synthesis NN cord-010092-uftc8inx 12157 8 of of IN cord-010092-uftc8inx 12157 9 defensins defensin NNS cord-010092-uftc8inx 12157 10 using use VBG cord-010092-uftc8inx 12157 11 the the DT cord-010092-uftc8inx 12157 12 chemical chemical NN cord-010092-uftc8inx 12157 13 and and CC cord-010092-uftc8inx 12157 14 recombinant recombinant JJ cord-010092-uftc8inx 12157 15 approach approach NN cord-010092-uftc8inx 12157 16 presents present VBZ cord-010092-uftc8inx 12157 17 quite quite PDT cord-010092-uftc8inx 12157 18 a a DT cord-010092-uftc8inx 12157 19 challenge challenge NN cord-010092-uftc8inx 12157 20 . . . cord-010092-uftc8inx 12158 1 Moreover moreover RB cord-010092-uftc8inx 12158 2 , , , cord-010092-uftc8inx 12158 3 purification purification NN cord-010092-uftc8inx 12158 4 from from IN cord-010092-uftc8inx 12158 5 the the DT cord-010092-uftc8inx 12158 6 natural natural JJ cord-010092-uftc8inx 12158 7 source source NN cord-010092-uftc8inx 12158 8 can can MD cord-010092-uftc8inx 12158 9 be be VB cord-010092-uftc8inx 12158 10 very very RB cord-010092-uftc8inx 12158 11 difficult difficult JJ cord-010092-uftc8inx 12158 12 because because IN cord-010092-uftc8inx 12158 13 the the DT cord-010092-uftc8inx 12158 14 large large JJ cord-010092-uftc8inx 12158 15 number number NN cord-010092-uftc8inx 12158 16 of of IN cord-010092-uftc8inx 12158 17 neutrophils neutrophil NNS cord-010092-uftc8inx 12158 18 is be VBZ cord-010092-uftc8inx 12158 19 needed need VBN cord-010092-uftc8inx 12158 20 to to TO cord-010092-uftc8inx 12158 21 obtain obtain VB cord-010092-uftc8inx 12158 22 a a DT cord-010092-uftc8inx 12158 23 sufficient sufficient JJ cord-010092-uftc8inx 12158 24 amount amount NN cord-010092-uftc8inx 12158 25 of of IN cord-010092-uftc8inx 12158 26 protein protein NN cord-010092-uftc8inx 12158 27 . . . cord-010092-uftc8inx 12159 1 In in IN cord-010092-uftc8inx 12159 2 blood blood NN cord-010092-uftc8inx 12159 3 banks bank NNS cord-010092-uftc8inx 12159 4 , , , cord-010092-uftc8inx 12159 5 leukocyte leukocyte NN cord-010092-uftc8inx 12159 6 reduction reduction NN cord-010092-uftc8inx 12159 7 filters filter NNS cord-010092-uftc8inx 12159 8 are be VBP cord-010092-uftc8inx 12159 9 used use VBN cord-010092-uftc8inx 12159 10 to to TO cord-010092-uftc8inx 12159 11 remove remove VB cord-010092-uftc8inx 12159 12 leukocytes leukocyte NNS cord-010092-uftc8inx 12159 13 from from IN cord-010092-uftc8inx 12159 14 blood blood NN cord-010092-uftc8inx 12159 15 components component NNS cord-010092-uftc8inx 12159 16 in in IN cord-010092-uftc8inx 12159 17 order order NN cord-010092-uftc8inx 12159 18 to to TO cord-010092-uftc8inx 12159 19 prevent prevent VB cord-010092-uftc8inx 12159 20 adverse adverse JJ cord-010092-uftc8inx 12159 21 transfusion transfusion NN cord-010092-uftc8inx 12159 22 reactions reaction NNS cord-010092-uftc8inx 12159 23 . . . cord-010092-uftc8inx 12160 1 Leukofilters leukofilter NNS cord-010092-uftc8inx 12160 2 contain contain VBP cord-010092-uftc8inx 12160 3 high high JJ cord-010092-uftc8inx 12160 4 numbers number NNS cord-010092-uftc8inx 12160 5 of of IN cord-010092-uftc8inx 12160 6 normal normal JJ cord-010092-uftc8inx 12160 7 human human JJ cord-010092-uftc8inx 12160 8 cells cell NNS cord-010092-uftc8inx 12160 9 and and CC cord-010092-uftc8inx 12160 10 discard discard VB cord-010092-uftc8inx 12160 11 after after IN cord-010092-uftc8inx 12160 12 use use NN cord-010092-uftc8inx 12160 13 . . . cord-010092-uftc8inx 12161 1 Aims aim VBZ cord-010092-uftc8inx 12161 2 : : : cord-010092-uftc8inx 12162 1 The the DT cord-010092-uftc8inx 12162 2 aim aim NN cord-010092-uftc8inx 12162 3 of of IN cord-010092-uftc8inx 12162 4 this this DT cord-010092-uftc8inx 12162 5 study study NN cord-010092-uftc8inx 12162 6 was be VBD cord-010092-uftc8inx 12162 7 to to TO cord-010092-uftc8inx 12162 8 purify purify VB cord-010092-uftc8inx 12162 9 a a DT cord-010092-uftc8inx 12162 10 - - HYPH cord-010092-uftc8inx 12162 11 defensins defensin NNS cord-010092-uftc8inx 12162 12 from from IN cord-010092-uftc8inx 12162 13 neutrophils neutrophil NNS cord-010092-uftc8inx 12162 14 trapped trap VBN cord-010092-uftc8inx 12162 15 in in IN cord-010092-uftc8inx 12162 16 leukocyte leukocyte NN cord-010092-uftc8inx 12162 17 reduction reduction NN cord-010092-uftc8inx 12162 18 filters filter NNS cord-010092-uftc8inx 12162 19 . . . cord-010092-uftc8inx 12163 1 Methods method NNS cord-010092-uftc8inx 12163 2 : : : cord-010092-uftc8inx 12163 3 Blood blood NN cord-010092-uftc8inx 12163 4 bags bag NNS cord-010092-uftc8inx 12163 5 from from IN cord-010092-uftc8inx 12163 6 healthy healthy JJ cord-010092-uftc8inx 12163 7 blood blood NN cord-010092-uftc8inx 12163 8 donors donor NNS cord-010092-uftc8inx 12163 9 were be VBD cord-010092-uftc8inx 12163 10 collected collect VBN cord-010092-uftc8inx 12163 11 after after IN cord-010092-uftc8inx 12163 12 written write VBN cord-010092-uftc8inx 12163 13 consent consent NN cord-010092-uftc8inx 12163 14 . . . cord-010092-uftc8inx 12164 1 All all DT cord-010092-uftc8inx 12164 2 donors donor NNS cord-010092-uftc8inx 12164 3 were be VBD cord-010092-uftc8inx 12164 4 screened screen VBN cord-010092-uftc8inx 12164 5 for for IN cord-010092-uftc8inx 12164 6 infectious infectious JJ cord-010092-uftc8inx 12164 7 diseases disease NNS cord-010092-uftc8inx 12164 8 ( ( -LRB- cord-010092-uftc8inx 12164 9 HBV HBV NNP cord-010092-uftc8inx 12164 10 , , , cord-010092-uftc8inx 12164 11 HCV HCV NNP cord-010092-uftc8inx 12164 12 and and CC cord-010092-uftc8inx 12164 13 HIV HIV NNP cord-010092-uftc8inx 12164 14 ) ) -RRB- cord-010092-uftc8inx 12164 15 and and CC cord-010092-uftc8inx 12164 16 negative negative JJ cord-010092-uftc8inx 12164 17 samples sample NNS cord-010092-uftc8inx 12164 18 were be VBD cord-010092-uftc8inx 12164 19 included include VBN cord-010092-uftc8inx 12164 20 in in IN cord-010092-uftc8inx 12164 21 the the DT cord-010092-uftc8inx 12164 22 study study NN cord-010092-uftc8inx 12164 23 . . . cord-010092-uftc8inx 12165 1 Blood blood NN cord-010092-uftc8inx 12165 2 bags bag NNS cord-010092-uftc8inx 12165 3 were be VBD cord-010092-uftc8inx 12165 4 filtered filter VBN cord-010092-uftc8inx 12165 5 at at IN cord-010092-uftc8inx 12165 6 22 22 CD cord-010092-uftc8inx 12165 7 ° ° NN cord-010092-uftc8inx 12165 8 C c NN cord-010092-uftc8inx 12165 9 by by IN cord-010092-uftc8inx 12165 10 Leukoflex Leukoflex NNP cord-010092-uftc8inx 12165 11 LST-1 LST-1 NNPS cord-010092-uftc8inx 12165 12 filters filter NNS cord-010092-uftc8inx 12165 13 . . . cord-010092-uftc8inx 12166 1 The the DT cord-010092-uftc8inx 12166 2 cells cell NNS cord-010092-uftc8inx 12166 3 were be VBD cord-010092-uftc8inx 12166 4 extracted extract VBN cord-010092-uftc8inx 12166 5 from from IN cord-010092-uftc8inx 12166 6 the the DT cord-010092-uftc8inx 12166 7 filters filter NNS cord-010092-uftc8inx 12166 8 by by IN cord-010092-uftc8inx 12166 9 back back NN cord-010092-uftc8inx 12166 10 - - HYPH cord-010092-uftc8inx 12166 11 flushing flush VBG cord-010092-uftc8inx 12166 12 with with IN cord-010092-uftc8inx 12166 13 cold cold JJ cord-010092-uftc8inx 12166 14 phosphate phosphate NN cord-010092-uftc8inx 12166 15 buffered buffer VBN cord-010092-uftc8inx 12166 16 saline saline NN cord-010092-uftc8inx 12166 17 ( ( -LRB- cord-010092-uftc8inx 12166 18 PBS PBS NNP cord-010092-uftc8inx 12166 19 ) ) -RRB- cord-010092-uftc8inx 12166 20 , , , cord-010092-uftc8inx 12166 21 pH pH NNP cord-010092-uftc8inx 12166 22 7.4 7.4 CD cord-010092-uftc8inx 12166 23 , , , cord-010092-uftc8inx 12166 24 without without IN cord-010092-uftc8inx 12166 25 MgCl2 mgcl2 NN cord-010092-uftc8inx 12166 26 and and CC cord-010092-uftc8inx 12166 27 CaCl2 CaCl2 NNP cord-010092-uftc8inx 12166 28 , , , cord-010092-uftc8inx 12166 29 containing contain VBG cord-010092-uftc8inx 12166 30 5 5 CD cord-010092-uftc8inx 12166 31 mM mm CD cord-010092-uftc8inx 12166 32 EDTA edta NN cord-010092-uftc8inx 12166 33 and and CC cord-010092-uftc8inx 12166 34 2.5 2.5 CD cord-010092-uftc8inx 12166 35 % % NN cord-010092-uftc8inx 12166 36 sucrose sucrose NN cord-010092-uftc8inx 12166 37 . . . cord-010092-uftc8inx 12167 1 The the DT cord-010092-uftc8inx 12167 2 PBS PBS NNP cord-010092-uftc8inx 12167 3 was be VBD cord-010092-uftc8inx 12167 4 homogenized homogenize VBN cord-010092-uftc8inx 12167 5 with with IN cord-010092-uftc8inx 12167 6 the the DT cord-010092-uftc8inx 12167 7 filter filter NN cord-010092-uftc8inx 12167 8 content content NN cord-010092-uftc8inx 12167 9 and and CC cord-010092-uftc8inx 12167 10 then then RB cord-010092-uftc8inx 12167 11 collected collect VBN cord-010092-uftc8inx 12167 12 in in IN cord-010092-uftc8inx 12167 13 a a DT cord-010092-uftc8inx 12167 14 sterile sterile JJ cord-010092-uftc8inx 12167 15 tube tube NN cord-010092-uftc8inx 12167 16 . . . cord-010092-uftc8inx 12168 1 Neutrophils neutrophil NNS cord-010092-uftc8inx 12168 2 were be VBD cord-010092-uftc8inx 12168 3 separated separate VBN cord-010092-uftc8inx 12168 4 from from IN cord-010092-uftc8inx 12168 5 mononuclear mononuclear JJ cord-010092-uftc8inx 12168 6 cells cell NNS cord-010092-uftc8inx 12168 7 by by IN cord-010092-uftc8inx 12168 8 Ficoll Ficoll NNP cord-010092-uftc8inx 12168 9 . . . cord-010092-uftc8inx 12169 1 Isolated isolated JJ cord-010092-uftc8inx 12169 2 neutrophils neutrophil NNS cord-010092-uftc8inx 12169 3 resuspended resuspend VBD cord-010092-uftc8inx 12169 4 in in IN cord-010092-uftc8inx 12169 5 PBS PBS NNP cord-010092-uftc8inx 12169 6 1X 1x CD cord-010092-uftc8inx 12169 7 at at IN cord-010092-uftc8inx 12169 8 a a DT cord-010092-uftc8inx 12169 9 concentration concentration NN cord-010092-uftc8inx 12169 10 of of IN cord-010092-uftc8inx 12169 11 1 1 CD cord-010092-uftc8inx 12169 12 9 9 CD cord-010092-uftc8inx 12169 13 10 10 CD cord-010092-uftc8inx 12169 14 7 7 CD cord-010092-uftc8inx 12169 15 cells cell NNS cord-010092-uftc8inx 12169 16 / / SYM cord-010092-uftc8inx 12169 17 ml ml NN cord-010092-uftc8inx 12169 18 . . . cord-010092-uftc8inx 12170 1 For for IN cord-010092-uftc8inx 12170 2 degranulation degranulation NN cord-010092-uftc8inx 12170 3 , , , cord-010092-uftc8inx 12170 4 cells cell NNS cord-010092-uftc8inx 12170 5 were be VBD cord-010092-uftc8inx 12170 6 stimulated stimulate VBN cord-010092-uftc8inx 12170 7 with with IN cord-010092-uftc8inx 12170 8 100 100 CD cord-010092-uftc8inx 12170 9 nM nm CD cord-010092-uftc8inx 12170 10 of of IN cord-010092-uftc8inx 12170 11 formylmethionyl formylmethionyl NNP cord-010092-uftc8inx 12170 12 - - HYPH cord-010092-uftc8inx 12170 13 leucyl leucyl NN cord-010092-uftc8inx 12170 14 - - HYPH cord-010092-uftc8inx 12170 15 phenylalanine phenylalanine NN cord-010092-uftc8inx 12170 16 ( ( -LRB- cord-010092-uftc8inx 12170 17 fMLP fmlp NN cord-010092-uftc8inx 12170 18 ) ) -RRB- cord-010092-uftc8inx 12170 19 for for IN cord-010092-uftc8inx 12170 20 5 5 CD cord-010092-uftc8inx 12170 21 min min NN cord-010092-uftc8inx 12170 22 followed follow VBN cord-010092-uftc8inx 12170 23 by by IN cord-010092-uftc8inx 12170 24 stimulation stimulation NN cord-010092-uftc8inx 12170 25 with with IN cord-010092-uftc8inx 12170 26 10 10 CD cord-010092-uftc8inx 12170 27 lM lM NNP cord-010092-uftc8inx 12170 28 of of IN cord-010092-uftc8inx 12170 29 cytochalasin cytochalasin NNP cord-010092-uftc8inx 12170 30 B B NNP cord-010092-uftc8inx 12170 31 for for IN cord-010092-uftc8inx 12170 32 5 5 CD cord-010092-uftc8inx 12170 33 min min NN cord-010092-uftc8inx 12170 34 . . . cord-010092-uftc8inx 12171 1 Supernatant Supernatant NNP cord-010092-uftc8inx 12171 2 was be VBD cord-010092-uftc8inx 12171 3 collected collect VBN cord-010092-uftc8inx 12171 4 by by IN cord-010092-uftc8inx 12171 5 centrifugation centrifugation NN cord-010092-uftc8inx 12171 6 at at IN cord-010092-uftc8inx 12171 7 200 200 CD cord-010092-uftc8inx 12171 8 9 9 CD cord-010092-uftc8inx 12171 9 g g NN cord-010092-uftc8inx 12171 10 for for IN cord-010092-uftc8inx 12171 11 6 6 CD cord-010092-uftc8inx 12171 12 min min NN cord-010092-uftc8inx 12171 13 . . . cord-010092-uftc8inx 12172 1 Supernatant Supernatant NNP cord-010092-uftc8inx 12172 2 was be VBD cord-010092-uftc8inx 12172 3 incubated incubate VBN cord-010092-uftc8inx 12172 4 with with IN cord-010092-uftc8inx 12172 5 mouse mouse NN cord-010092-uftc8inx 12172 6 monoclonal monoclonal JJ cord-010092-uftc8inx 12172 7 antibody antibody NN cord-010092-uftc8inx 12172 8 to to IN cord-010092-uftc8inx 12172 9 HNP HNP NNP cord-010092-uftc8inx 12172 10 1 1 CD cord-010092-uftc8inx 12172 11 - - SYM cord-010092-uftc8inx 12172 12 3 3 CD cord-010092-uftc8inx 12172 13 and and CC cord-010092-uftc8inx 12172 14 purification purification NN cord-010092-uftc8inx 12172 15 of of IN cord-010092-uftc8inx 12172 16 HNP HNP NNP cord-010092-uftc8inx 12172 17 1 1 CD cord-010092-uftc8inx 12172 18 - - SYM cord-010092-uftc8inx 12172 19 3 3 NNP cord-010092-uftc8inx 12172 20 was be VBD cord-010092-uftc8inx 12172 21 performed perform VBN cord-010092-uftc8inx 12172 22 by by IN cord-010092-uftc8inx 12172 23 lMacs lMacs NNP cord-010092-uftc8inx 12172 24 Protein Protein NNP cord-010092-uftc8inx 12172 25 G G NNP cord-010092-uftc8inx 12172 26 Microbeads Microbeads NNP cord-010092-uftc8inx 12172 27 system system NN cord-010092-uftc8inx 12172 28 . . . cord-010092-uftc8inx 12173 1 The the DT cord-010092-uftc8inx 12173 2 presence presence NN cord-010092-uftc8inx 12173 3 of of IN cord-010092-uftc8inx 12173 4 protein protein NN cord-010092-uftc8inx 12173 5 was be VBD cord-010092-uftc8inx 12173 6 confirmed confirm VBN cord-010092-uftc8inx 12173 7 by by IN cord-010092-uftc8inx 12173 8 Western western JJ cord-010092-uftc8inx 12173 9 Blot Blot NNP cord-010092-uftc8inx 12173 10 . . . cord-010092-uftc8inx 12174 1 Results result NNS cord-010092-uftc8inx 12174 2 : : : cord-010092-uftc8inx 12175 1 The the DT cord-010092-uftc8inx 12175 2 presence presence NN cord-010092-uftc8inx 12175 3 of of IN cord-010092-uftc8inx 12175 4 the the DT cord-010092-uftc8inx 12175 5 3.4 3.4 CD cord-010092-uftc8inx 12175 6 kDa kDa NNP cord-010092-uftc8inx 12175 7 band band NN cord-010092-uftc8inx 12175 8 was be VBD cord-010092-uftc8inx 12175 9 confirmed confirm VBN cord-010092-uftc8inx 12175 10 by by IN cord-010092-uftc8inx 12175 11 Western western JJ cord-010092-uftc8inx 12175 12 Blot Blot NNP cord-010092-uftc8inx 12175 13 , , , cord-010092-uftc8inx 12175 14 which which WDT cord-010092-uftc8inx 12175 15 corresponded correspond VBD cord-010092-uftc8inx 12175 16 to to IN cord-010092-uftc8inx 12175 17 the the DT cord-010092-uftc8inx 12175 18 size size NN cord-010092-uftc8inx 12175 19 of of IN cord-010092-uftc8inx 12175 20 the the DT cord-010092-uftc8inx 12175 21 a a NN cord-010092-uftc8inx 12175 22 - - HYPH cord-010092-uftc8inx 12175 23 defensins defensin NNS cord-010092-uftc8inx 12175 24 . . . cord-010092-uftc8inx 12176 1 Summary Summary NNP cord-010092-uftc8inx 12176 2 / / SYM cord-010092-uftc8inx 12176 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 12176 4 : : : cord-010092-uftc8inx 12177 1 The the DT cord-010092-uftc8inx 12177 2 development development NN cord-010092-uftc8inx 12177 3 of of IN cord-010092-uftc8inx 12177 4 defensins defensin NNS cord-010092-uftc8inx 12177 5 as as IN cord-010092-uftc8inx 12177 6 therapeutic therapeutic JJ cord-010092-uftc8inx 12177 7 products product NNS cord-010092-uftc8inx 12177 8 requires require VBZ cord-010092-uftc8inx 12177 9 access access NN cord-010092-uftc8inx 12177 10 to to IN cord-010092-uftc8inx 12177 11 a a DT cord-010092-uftc8inx 12177 12 steady steady JJ cord-010092-uftc8inx 12177 13 supply supply NN cord-010092-uftc8inx 12177 14 of of IN cord-010092-uftc8inx 12177 15 neutrophils neutrophil NNS cord-010092-uftc8inx 12177 16 . . . cord-010092-uftc8inx 12178 1 Our -PRON- PRP$ cord-010092-uftc8inx 12178 2 results result NNS cord-010092-uftc8inx 12178 3 indicated indicate VBD cord-010092-uftc8inx 12178 4 that that IN cord-010092-uftc8inx 12178 5 LST-1 LST-1 NNP cord-010092-uftc8inx 12178 6 filters filter NNS cord-010092-uftc8inx 12178 7 are be VBP cord-010092-uftc8inx 12178 8 economical economical JJ cord-010092-uftc8inx 12178 9 source source NN cord-010092-uftc8inx 12178 10 for for IN cord-010092-uftc8inx 12178 11 purifying purify VBG cord-010092-uftc8inx 12178 12 a a DT cord-010092-uftc8inx 12178 13 - - HYPH cord-010092-uftc8inx 12178 14 defensins defensin NNS cord-010092-uftc8inx 12178 15 . . . cord-010092-uftc8inx 12179 1 Anatomical Anatomical NNP cord-010092-uftc8inx 12179 2 Sciences Sciences NNPS cord-010092-uftc8inx 12179 3 , , , cord-010092-uftc8inx 12179 4 Abadan Abadan NNP cord-010092-uftc8inx 12179 5 School School NNP cord-010092-uftc8inx 12179 6 of of IN cord-010092-uftc8inx 12179 7 Medical Medical NNP cord-010092-uftc8inx 12179 8 Sciences Sciences NNPS cord-010092-uftc8inx 12179 9 , , , cord-010092-uftc8inx 12179 10 Abadan Abadan NNP cord-010092-uftc8inx 12179 11 , , , cord-010092-uftc8inx 12180 1 Iran Iran NNP cord-010092-uftc8inx 12180 2 Background Background NNP cord-010092-uftc8inx 12180 3 : : : cord-010092-uftc8inx 12180 4 Epigenetic epigenetic JJ cord-010092-uftc8inx 12180 5 reprogramming reprogramming NN cord-010092-uftc8inx 12180 6 of of IN cord-010092-uftc8inx 12180 7 terminally terminally RB cord-010092-uftc8inx 12180 8 differentiated differentiate VBN cord-010092-uftc8inx 12180 9 cell cell NN cord-010092-uftc8inx 12180 10 can can MD cord-010092-uftc8inx 12180 11 modify modify VB cord-010092-uftc8inx 12180 12 somatic somatic JJ cord-010092-uftc8inx 12180 13 cells cell NNS cord-010092-uftc8inx 12180 14 to to IN cord-010092-uftc8inx 12180 15 a a DT cord-010092-uftc8inx 12180 16 pluripotential pluripotential JJ cord-010092-uftc8inx 12180 17 state state NN cord-010092-uftc8inx 12180 18 . . . cord-010092-uftc8inx 12181 1 There there EX cord-010092-uftc8inx 12181 2 are be VBP cord-010092-uftc8inx 12181 3 several several JJ cord-010092-uftc8inx 12181 4 approaches approach NNS cord-010092-uftc8inx 12181 5 that that WDT cord-010092-uftc8inx 12181 6 induce induce VBP cord-010092-uftc8inx 12181 7 pluripotency pluripotency NN cord-010092-uftc8inx 12181 8 in in IN cord-010092-uftc8inx 12181 9 somatic somatic JJ cord-010092-uftc8inx 12181 10 cells cell NNS cord-010092-uftc8inx 12181 11 . . . cord-010092-uftc8inx 12182 1 Exposure exposure NN cord-010092-uftc8inx 12182 2 the the DT cord-010092-uftc8inx 12182 3 cells cell NNS cord-010092-uftc8inx 12182 4 with with IN cord-010092-uftc8inx 12182 5 the the DT cord-010092-uftc8inx 12182 6 embryonic embryonic JJ cord-010092-uftc8inx 12182 7 stem stem NN cord-010092-uftc8inx 12182 8 cell cell NN cord-010092-uftc8inx 12182 9 extract extract NN cord-010092-uftc8inx 12182 10 is be VBZ cord-010092-uftc8inx 12182 11 an an DT cord-010092-uftc8inx 12182 12 easy easy JJ cord-010092-uftc8inx 12182 13 way way NN cord-010092-uftc8inx 12182 14 , , , cord-010092-uftc8inx 12182 15 and and CC cord-010092-uftc8inx 12182 16 some some DT cord-010092-uftc8inx 12182 17 investigations investigation NNS cord-010092-uftc8inx 12182 18 were be VBD cord-010092-uftc8inx 12182 19 done do VBN cord-010092-uftc8inx 12182 20 on on IN cord-010092-uftc8inx 12182 21 fibroblast fibroblast NN cord-010092-uftc8inx 12182 22 cell cell NN cord-010092-uftc8inx 12182 23 line line NN cord-010092-uftc8inx 12182 24 . . . cord-010092-uftc8inx 12183 1 However however RB cord-010092-uftc8inx 12183 2 , , , cord-010092-uftc8inx 12183 3 its -PRON- PRP$ cord-010092-uftc8inx 12183 4 efficiency efficiency NN cord-010092-uftc8inx 12183 5 was be VBD cord-010092-uftc8inx 12183 6 low low JJ cord-010092-uftc8inx 12183 7 Aims Aims NNPS cord-010092-uftc8inx 12183 8 : : : cord-010092-uftc8inx 12184 1 The the DT cord-010092-uftc8inx 12184 2 purpose purpose NN cord-010092-uftc8inx 12184 3 of of IN cord-010092-uftc8inx 12184 4 this this DT cord-010092-uftc8inx 12184 5 study study NN cord-010092-uftc8inx 12184 6 was be VBD cord-010092-uftc8inx 12184 7 to to TO cord-010092-uftc8inx 12184 8 increase increase VB cord-010092-uftc8inx 12184 9 the the DT cord-010092-uftc8inx 12184 10 number number NN cord-010092-uftc8inx 12184 11 of of IN cord-010092-uftc8inx 12184 12 reprogrammed reprogramme VBN cord-010092-uftc8inx 12184 13 granulosa granulosa JJ cord-010092-uftc8inx 12184 14 cell cell NN cord-010092-uftc8inx 12184 15 as as IN cord-010092-uftc8inx 12184 16 a a DT cord-010092-uftc8inx 12184 17 full full JJ cord-010092-uftc8inx 12184 18 differentiated differentiated JJ cord-010092-uftc8inx 12184 19 cell cell NN cord-010092-uftc8inx 12184 20 into into IN cord-010092-uftc8inx 12184 21 pluripotential pluripotential JJ cord-010092-uftc8inx 12184 22 state state NN cord-010092-uftc8inx 12184 23 Methods method NNS cord-010092-uftc8inx 12184 24 : : : cord-010092-uftc8inx 12184 25 The the DT cord-010092-uftc8inx 12184 26 human human JJ cord-010092-uftc8inx 12184 27 granulosa granulosa NN cord-010092-uftc8inx 12184 28 cells cell NNS cord-010092-uftc8inx 12184 29 were be VBD cord-010092-uftc8inx 12184 30 cultured culture VBN cord-010092-uftc8inx 12184 31 in in IN cord-010092-uftc8inx 12184 32 the the DT cord-010092-uftc8inx 12184 33 medium medium NN cord-010092-uftc8inx 12184 34 containing contain VBG cord-010092-uftc8inx 12184 35 5-Aza 5-aza JJ cord-010092-uftc8inx 12184 36 - - HYPH cord-010092-uftc8inx 12184 37 Deoxycytidine Deoxycytidine NNP cord-010092-uftc8inx 12184 38 and and CC cord-010092-uftc8inx 12184 39 trichostatin trichostatin NNP cord-010092-uftc8inx 12184 40 A. a. NN cord-010092-uftc8inx 12185 1 Then then RB cord-010092-uftc8inx 12185 2 , , , cord-010092-uftc8inx 12185 3 the the DT cord-010092-uftc8inx 12185 4 cells cell NNS cord-010092-uftc8inx 12185 5 were be VBD cord-010092-uftc8inx 12185 6 exposed expose VBN cord-010092-uftc8inx 12185 7 to to IN cord-010092-uftc8inx 12185 8 mouse mouse NN cord-010092-uftc8inx 12185 9 ESCs esc NNS cord-010092-uftc8inx 12185 10 extract extract VB cord-010092-uftc8inx 12185 11 and and CC cord-010092-uftc8inx 12185 12 co co JJ cord-010092-uftc8inx 12185 13 - - JJ cord-010092-uftc8inx 12185 14 cultured cultured JJ cord-010092-uftc8inx 12185 15 with with IN cord-010092-uftc8inx 12185 16 mouse mouse NN cord-010092-uftc8inx 12185 17 embryonic embryonic JJ cord-010092-uftc8inx 12185 18 fibroblast fibroblast NN cord-010092-uftc8inx 12185 19 in in IN cord-010092-uftc8inx 12185 20 the the DT cord-010092-uftc8inx 12185 21 presence presence NN cord-010092-uftc8inx 12185 22 of of IN cord-010092-uftc8inx 12185 23 leukemia leukemia NN cord-010092-uftc8inx 12185 24 inhibitory inhibitory JJ cord-010092-uftc8inx 12185 25 factor factor NN cord-010092-uftc8inx 12185 26 ( ( -LRB- cord-010092-uftc8inx 12185 27 LIF LIF NNP cord-010092-uftc8inx 12185 28 ) ) -RRB- cord-010092-uftc8inx 12185 29 . . . cord-010092-uftc8inx 12186 1 Alkaline alkaline JJ cord-010092-uftc8inx 12186 2 phosphatase phosphatase NN cord-010092-uftc8inx 12186 3 test test NN cord-010092-uftc8inx 12186 4 and and CC cord-010092-uftc8inx 12186 5 also also RB cord-010092-uftc8inx 12186 6 immunohistochemistry immunohistochemistry NN cord-010092-uftc8inx 12186 7 staining staining NN cord-010092-uftc8inx 12186 8 for for IN cord-010092-uftc8inx 12186 9 Oct4 Oct4 NNP cord-010092-uftc8inx 12186 10 , , , cord-010092-uftc8inx 12186 11 Sox2 Sox2 NNP cord-010092-uftc8inx 12186 12 and and CC cord-010092-uftc8inx 12186 13 Nanog Nanog NNP cord-010092-uftc8inx 12186 14 were be VBD cord-010092-uftc8inx 12186 15 performed perform VBN cord-010092-uftc8inx 12186 16 after after IN cord-010092-uftc8inx 12186 17 24 24 CD cord-010092-uftc8inx 12186 18 and and CC cord-010092-uftc8inx 12186 19 72 72 CD cord-010092-uftc8inx 12186 20 h h NN cord-010092-uftc8inx 12186 21 and and CC cord-010092-uftc8inx 12186 22 1 1 CD cord-010092-uftc8inx 12186 23 week week NN cord-010092-uftc8inx 12186 24 Results result NNS cord-010092-uftc8inx 12186 25 : : : cord-010092-uftc8inx 12187 1 The the DT cord-010092-uftc8inx 12187 2 results result NNS cord-010092-uftc8inx 12187 3 indicated indicate VBD cord-010092-uftc8inx 12187 4 that that IN cord-010092-uftc8inx 12187 5 after after IN cord-010092-uftc8inx 12187 6 24 24 CD cord-010092-uftc8inx 12187 7 h h NN cord-010092-uftc8inx 12187 8 the the DT cord-010092-uftc8inx 12187 9 granulosa granulosa NN cord-010092-uftc8inx 12187 10 cells cell NNS cord-010092-uftc8inx 12187 11 were be VBD cord-010092-uftc8inx 12187 12 revealed reveal VBN cord-010092-uftc8inx 12187 13 a a DT cord-010092-uftc8inx 12187 14 round round NN cord-010092-uftc8inx 12187 15 and and CC cord-010092-uftc8inx 12187 16 expanded expand VBN cord-010092-uftc8inx 12187 17 morphology morphology NN cord-010092-uftc8inx 12187 18 . . . cord-010092-uftc8inx 12188 1 The the DT cord-010092-uftc8inx 12188 2 cells cell NNS cord-010092-uftc8inx 12188 3 in in IN cord-010092-uftc8inx 12188 4 all all DT cord-010092-uftc8inx 12188 5 groups group NNS cord-010092-uftc8inx 12188 6 except except IN cord-010092-uftc8inx 12188 7 in in IN cord-010092-uftc8inx 12188 8 negative negative JJ cord-010092-uftc8inx 12188 9 control control NN cord-010092-uftc8inx 12188 10 , , , cord-010092-uftc8inx 12188 11 were be VBD cord-010092-uftc8inx 12188 12 showed show VBN cord-010092-uftc8inx 12188 13 alkaline alkaline JJ cord-010092-uftc8inx 12188 14 phosphatase phosphatase NN cord-010092-uftc8inx 12188 15 activity activity NN cord-010092-uftc8inx 12188 16 . . . cord-010092-uftc8inx 12189 1 The the DT cord-010092-uftc8inx 12189 2 cells cell NNS cord-010092-uftc8inx 12189 3 that that WDT cord-010092-uftc8inx 12189 4 were be VBD cord-010092-uftc8inx 12189 5 cultured culture VBN cord-010092-uftc8inx 12189 6 in in IN cord-010092-uftc8inx 12189 7 medium medium JJ cord-010092-uftc8inx 12189 8 containing contain VBG cord-010092-uftc8inx 12189 9 5-Aza 5-aza JJ cord-010092-uftc8inx 12189 10 - - : cord-010092-uftc8inx 12189 11 Deoxycytidine Deoxycytidine NNP cord-010092-uftc8inx 12189 12 and and CC cord-010092-uftc8inx 12189 13 Trichostatin Trichostatin NNP cord-010092-uftc8inx 12189 14 A A NNP cord-010092-uftc8inx 12189 15 and and CC cord-010092-uftc8inx 12189 16 exposed expose VBN cord-010092-uftc8inx 12189 17 to to IN cord-010092-uftc8inx 12189 18 the the DT cord-010092-uftc8inx 12189 19 extract extract NN cord-010092-uftc8inx 12189 20 had have VBD cord-010092-uftc8inx 12189 21 the the DT cord-010092-uftc8inx 12189 22 most most JJS cord-010092-uftc8inx 12189 23 numbers number NNS cord-010092-uftc8inx 12189 24 of of IN cord-010092-uftc8inx 12189 25 alkaline alkaline JJ cord-010092-uftc8inx 12189 26 phosphatase phosphatase NN cord-010092-uftc8inx 12189 27 positive positive JJ cord-010092-uftc8inx 12189 28 cells cell NNS cord-010092-uftc8inx 12189 29 . . . cord-010092-uftc8inx 12190 1 Immunocytochemistry Immunocytochemistry NNP cord-010092-uftc8inx 12190 2 showed show VBD cord-010092-uftc8inx 12190 3 the the DT cord-010092-uftc8inx 12190 4 granulosa granulosa NN cord-010092-uftc8inx 12190 5 cells cell NNS cord-010092-uftc8inx 12190 6 that that WDT cord-010092-uftc8inx 12190 7 were be VBD cord-010092-uftc8inx 12190 8 cultured culture VBN cord-010092-uftc8inx 12190 9 in in IN cord-010092-uftc8inx 12190 10 medium medium JJ cord-010092-uftc8inx 12190 11 containing contain VBG cord-010092-uftc8inx 12190 12 5-Aza 5-aza JJ cord-010092-uftc8inx 12190 13 - - : cord-010092-uftc8inx 12190 14 Deoxycytidine Deoxycytidine NNP cord-010092-uftc8inx 12190 15 and and CC cord-010092-uftc8inx 12190 16 trichostatin trichostatin VBZ cord-010092-uftc8inx 12190 17 A a DT cord-010092-uftc8inx 12190 18 with with IN cord-010092-uftc8inx 12190 19 extract extract NN cord-010092-uftc8inx 12190 20 expressed express VBD cord-010092-uftc8inx 12190 21 Oct4 Oct4 NNP cord-010092-uftc8inx 12190 22 with with IN cord-010092-uftc8inx 12190 23 weak weak JJ cord-010092-uftc8inx 12190 24 intensity intensity NN cord-010092-uftc8inx 12190 25 after after IN cord-010092-uftc8inx 12190 26 24 24 CD cord-010092-uftc8inx 12190 27 h. h. NN cord-010092-uftc8inx 12191 1 No no DT cord-010092-uftc8inx 12191 2 expression expression NN cord-010092-uftc8inx 12191 3 of of IN cord-010092-uftc8inx 12191 4 Oct4 Oct4 NNP cord-010092-uftc8inx 12191 5 , , , cord-010092-uftc8inx 12191 6 Sox2 Sox2 NNP cord-010092-uftc8inx 12191 7 and and CC cord-010092-uftc8inx 12191 8 Nanog Nanog NNP cord-010092-uftc8inx 12191 9 were be VBD cord-010092-uftc8inx 12191 10 observed observe VBN cord-010092-uftc8inx 12191 11 in in IN cord-010092-uftc8inx 12191 12 other other JJ cord-010092-uftc8inx 12191 13 groups group NNS cord-010092-uftc8inx 12191 14 at at IN cord-010092-uftc8inx 12191 15 the the DT cord-010092-uftc8inx 12191 16 same same JJ cord-010092-uftc8inx 12191 17 time time NN cord-010092-uftc8inx 12191 18 . . . cord-010092-uftc8inx 12192 1 After after IN cord-010092-uftc8inx 12192 2 72 72 CD cord-010092-uftc8inx 12192 3 h h NN cord-010092-uftc8inx 12192 4 , , , cord-010092-uftc8inx 12192 5 Oct4 Oct4 NNP cord-010092-uftc8inx 12192 6 , , , cord-010092-uftc8inx 12192 7 Sox2 Sox2 NNP cord-010092-uftc8inx 12192 8 and and CC cord-010092-uftc8inx 12192 9 Nanog Nanog NNP cord-010092-uftc8inx 12192 10 were be VBD cord-010092-uftc8inx 12192 11 over over RB cord-010092-uftc8inx 12192 12 expressed express VBN cord-010092-uftc8inx 12192 13 in in IN cord-010092-uftc8inx 12192 14 the the DT cord-010092-uftc8inx 12192 15 cells cell NNS cord-010092-uftc8inx 12192 16 that that WDT cord-010092-uftc8inx 12192 17 were be VBD cord-010092-uftc8inx 12192 18 treated treat VBN cord-010092-uftc8inx 12192 19 with with IN cord-010092-uftc8inx 12192 20 5-Aza 5-aza JJ cord-010092-uftc8inx 12192 21 - - : cord-010092-uftc8inx 12192 22 Deoxycytidine Deoxycytidine NNP cord-010092-uftc8inx 12192 23 , , , cord-010092-uftc8inx 12192 24 Trichostatin Trichostatin NNP cord-010092-uftc8inx 12192 25 A A NNP cord-010092-uftc8inx 12192 26 and and CC cord-010092-uftc8inx 12192 27 extract extract NN cord-010092-uftc8inx 12192 28 . . . cord-010092-uftc8inx 12193 1 Furthermore furthermore RB cord-010092-uftc8inx 12193 2 , , , cord-010092-uftc8inx 12193 3 there there EX cord-010092-uftc8inx 12193 4 was be VBD cord-010092-uftc8inx 12193 5 high high JJ cord-010092-uftc8inx 12193 6 expression expression NN cord-010092-uftc8inx 12193 7 of of IN cord-010092-uftc8inx 12193 8 Oct4 Oct4 NNP cord-010092-uftc8inx 12193 9 in in IN cord-010092-uftc8inx 12193 10 the the DT cord-010092-uftc8inx 12193 11 granulosa granulosa NN cord-010092-uftc8inx 12193 12 cells cell NNS cord-010092-uftc8inx 12193 13 that that WDT cord-010092-uftc8inx 12193 14 were be VBD cord-010092-uftc8inx 12193 15 cultured culture VBN cord-010092-uftc8inx 12193 16 in in IN cord-010092-uftc8inx 12193 17 medium medium JJ cord-010092-uftc8inx 12193 18 containing contain VBG cord-010092-uftc8inx 12193 19 DMSO DMSO NNP cord-010092-uftc8inx 12193 20 and and CC cord-010092-uftc8inx 12193 21 exposed expose VBN cord-010092-uftc8inx 12193 22 to to IN cord-010092-uftc8inx 12193 23 the the DT cord-010092-uftc8inx 12193 24 extract extract NN cord-010092-uftc8inx 12193 25 . . . cord-010092-uftc8inx 12194 1 After after IN cord-010092-uftc8inx 12194 2 one one CD cord-010092-uftc8inx 12194 3 week week NN cord-010092-uftc8inx 12194 4 , , , cord-010092-uftc8inx 12194 5 the the DT cord-010092-uftc8inx 12194 6 expression expression NN cord-010092-uftc8inx 12194 7 of of IN cord-010092-uftc8inx 12194 8 Oct4 Oct4 NNP cord-010092-uftc8inx 12194 9 and and CC cord-010092-uftc8inx 12194 10 SOX2 SOX2 NNP cord-010092-uftc8inx 12194 11 in in IN cord-010092-uftc8inx 12194 12 the the DT cord-010092-uftc8inx 12194 13 granulosa granulosa NN cord-010092-uftc8inx 12194 14 cells cell NNS cord-010092-uftc8inx 12194 15 that that WDT cord-010092-uftc8inx 12194 16 were be VBD cord-010092-uftc8inx 12194 17 cultured culture VBN cord-010092-uftc8inx 12194 18 in in IN cord-010092-uftc8inx 12194 19 medium medium JJ cord-010092-uftc8inx 12194 20 containing contain VBG cord-010092-uftc8inx 12194 21 DMSO DMSO NNP cord-010092-uftc8inx 12194 22 and and CC cord-010092-uftc8inx 12194 23 exposed expose VBN cord-010092-uftc8inx 12194 24 to to IN cord-010092-uftc8inx 12194 25 the the DT cord-010092-uftc8inx 12194 26 extract extract NN cord-010092-uftc8inx 12194 27 was be VBD cord-010092-uftc8inx 12194 28 continued continue VBN cord-010092-uftc8inx 12194 29 while while IN cord-010092-uftc8inx 12194 30 its -PRON- PRP$ cord-010092-uftc8inx 12194 31 expression expression NN cord-010092-uftc8inx 12194 32 ceased cease VBD cord-010092-uftc8inx 12194 33 in in IN cord-010092-uftc8inx 12194 34 the the DT cord-010092-uftc8inx 12194 35 other other JJ cord-010092-uftc8inx 12194 36 groups group NNS cord-010092-uftc8inx 12194 37 . . . cord-010092-uftc8inx 12195 1 The the DT cord-010092-uftc8inx 12195 2 expression expression NN cord-010092-uftc8inx 12195 3 of of IN cord-010092-uftc8inx 12195 4 Nanog Nanog NNP cord-010092-uftc8inx 12195 5 were be VBD cord-010092-uftc8inx 12195 6 ceased cease VBN cord-010092-uftc8inx 12195 7 in in IN cord-010092-uftc8inx 12195 8 all all DT cord-010092-uftc8inx 12195 9 groups group NNS cord-010092-uftc8inx 12195 10 after after IN cord-010092-uftc8inx 12195 11 one one CD cord-010092-uftc8inx 12195 12 week week NN cord-010092-uftc8inx 12196 1 Summary Summary NNP cord-010092-uftc8inx 12196 2 / / SYM cord-010092-uftc8inx 12196 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 12196 4 : : : cord-010092-uftc8inx 12197 1 Present present JJ cord-010092-uftc8inx 12197 2 study study NN cord-010092-uftc8inx 12197 3 revealed reveal VBD cord-010092-uftc8inx 12197 4 that that IN cord-010092-uftc8inx 12197 5 the the DT cord-010092-uftc8inx 12197 6 inhibitors inhibitor NNS cord-010092-uftc8inx 12197 7 of of IN cord-010092-uftc8inx 12197 8 the the DT cord-010092-uftc8inx 12197 9 methyl methyl NN cord-010092-uftc8inx 12197 10 transferase transferase NN cord-010092-uftc8inx 12197 11 ( ( -LRB- cord-010092-uftc8inx 12197 12 5-Aza 5-aza JJ cord-010092-uftc8inx 12197 13 - - HYPH cord-010092-uftc8inx 12197 14 Deoxycytidine Deoxycytidine NNP cord-010092-uftc8inx 12197 15 ) ) -RRB- cord-010092-uftc8inx 12197 16 and and CC cord-010092-uftc8inx 12197 17 histone histone NN cord-010092-uftc8inx 12197 18 deacetylase deacetylase NN cord-010092-uftc8inx 12197 19 ( ( -LRB- cord-010092-uftc8inx 12197 20 trichostatin trichostatin NNP cord-010092-uftc8inx 12197 21 A A NNP cord-010092-uftc8inx 12197 22 ) ) -RRB- cord-010092-uftc8inx 12197 23 could could MD cord-010092-uftc8inx 12197 24 delete delete VB cord-010092-uftc8inx 12197 25 the the DT cord-010092-uftc8inx 12197 26 epigenetic epigenetic JJ cord-010092-uftc8inx 12197 27 markers marker NNS cord-010092-uftc8inx 12197 28 and and CC cord-010092-uftc8inx 12197 29 improved improved JJ cord-010092-uftc8inx 12197 30 cells cell NNS cord-010092-uftc8inx 12197 31 reprogramming reprogramme VBG cord-010092-uftc8inx 12197 32 by by IN cord-010092-uftc8inx 12197 33 administration administration NN cord-010092-uftc8inx 12197 34 of of IN cord-010092-uftc8inx 12197 35 the the DT cord-010092-uftc8inx 12197 36 extract extract NN cord-010092-uftc8inx 12197 37 Abstract Abstract NNP cord-010092-uftc8inx 12197 38 withdrawn withdraw VBN cord-010092-uftc8inx 12197 39 . . . cord-010092-uftc8inx 12198 1 Abstract Abstract NNP cord-010092-uftc8inx 12198 2 withdrawn withdraw VBN cord-010092-uftc8inx 12198 3 . . . cord-010092-uftc8inx 12199 1 Abstract Abstract NNP cord-010092-uftc8inx 12199 2 withdrawn withdraw VBN cord-010092-uftc8inx 12199 3 . . . cord-010092-uftc8inx 12200 1 Background background NN cord-010092-uftc8inx 12200 2 : : : cord-010092-uftc8inx 12201 1 Mesenchymal Mesenchymal NNS cord-010092-uftc8inx 12201 2 stem stem VBP cord-010092-uftc8inx 12201 3 cells cell NNS cord-010092-uftc8inx 12201 4 ( ( -LRB- cord-010092-uftc8inx 12201 5 MSCs msc NNS cord-010092-uftc8inx 12201 6 ) ) -RRB- cord-010092-uftc8inx 12201 7 are be VBP cord-010092-uftc8inx 12201 8 adherent adherent JJ cord-010092-uftc8inx 12201 9 spindle spindle NN cord-010092-uftc8inx 12201 10 shape shape NN cord-010092-uftc8inx 12201 11 cells cell NNS cord-010092-uftc8inx 12201 12 expressing express VBG cord-010092-uftc8inx 12201 13 different different JJ cord-010092-uftc8inx 12201 14 surface surface NN cord-010092-uftc8inx 12201 15 markers marker NNS cord-010092-uftc8inx 12201 16 . . . cord-010092-uftc8inx 12202 1 They -PRON- PRP cord-010092-uftc8inx 12202 2 show show VBP cord-010092-uftc8inx 12202 3 special special JJ cord-010092-uftc8inx 12202 4 criteria criterion NNS cord-010092-uftc8inx 12202 5 including include VBG cord-010092-uftc8inx 12202 6 , , , cord-010092-uftc8inx 12202 7 paracrine paracrine JJ cord-010092-uftc8inx 12202 8 effects effect NNS cord-010092-uftc8inx 12202 9 , , , cord-010092-uftc8inx 12202 10 differentiation differentiation NN cord-010092-uftc8inx 12202 11 to to IN cord-010092-uftc8inx 12202 12 several several JJ cord-010092-uftc8inx 12202 13 tissue tissue NN cord-010092-uftc8inx 12202 14 cells cell NNS cord-010092-uftc8inx 12202 15 , , , cord-010092-uftc8inx 12202 16 migration migration NN cord-010092-uftc8inx 12202 17 , , , cord-010092-uftc8inx 12202 18 immunomodulatory immunomodulatory JJ cord-010092-uftc8inx 12202 19 and and CC cord-010092-uftc8inx 12202 20 regenerative regenerative JJ cord-010092-uftc8inx 12202 21 potentialities potentiality NNS cord-010092-uftc8inx 12202 22 . . . cord-010092-uftc8inx 12203 1 MSCs msc NNS cord-010092-uftc8inx 12203 2 are be VBP cord-010092-uftc8inx 12203 3 isolated isolate VBN cord-010092-uftc8inx 12203 4 from from IN cord-010092-uftc8inx 12203 5 different different JJ cord-010092-uftc8inx 12203 6 sources source NNS cord-010092-uftc8inx 12203 7 and and CC cord-010092-uftc8inx 12203 8 employed employ VBN cord-010092-uftc8inx 12203 9 as as IN cord-010092-uftc8inx 12203 10 therapeutic therapeutic JJ cord-010092-uftc8inx 12203 11 tools tool NNS cord-010092-uftc8inx 12203 12 to to TO cord-010092-uftc8inx 12203 13 treat treat VB cord-010092-uftc8inx 12203 14 several several JJ cord-010092-uftc8inx 12203 15 diseases disease NNS cord-010092-uftc8inx 12203 16 and and CC cord-010092-uftc8inx 12203 17 injuries injury NNS cord-010092-uftc8inx 12203 18 . . . cord-010092-uftc8inx 12204 1 However however RB cord-010092-uftc8inx 12204 2 , , , cord-010092-uftc8inx 12204 3 some some DT cord-010092-uftc8inx 12204 4 of of IN cord-010092-uftc8inx 12204 5 MSCs mscs JJ cord-010092-uftc8inx 12204 6 properties property NNS cord-010092-uftc8inx 12204 7 including include VBG cord-010092-uftc8inx 12204 8 secretion secretion NN cord-010092-uftc8inx 12204 9 of of IN cord-010092-uftc8inx 12204 10 growth growth NN cord-010092-uftc8inx 12204 11 factors factor NNS cord-010092-uftc8inx 12204 12 and and CC cord-010092-uftc8inx 12204 13 migration migration NN cord-010092-uftc8inx 12204 14 ability ability NN cord-010092-uftc8inx 12204 15 are be VBP cord-010092-uftc8inx 12204 16 controversial controversial JJ cord-010092-uftc8inx 12204 17 especially especially RB cord-010092-uftc8inx 12204 18 during during IN cord-010092-uftc8inx 12204 19 remission remission NN cord-010092-uftc8inx 12204 20 or or CC cord-010092-uftc8inx 12204 21 in in IN cord-010092-uftc8inx 12204 22 presence presence NN cord-010092-uftc8inx 12204 23 of of IN cord-010092-uftc8inx 12204 24 tumor tumor NN cord-010092-uftc8inx 12204 25 . . . cord-010092-uftc8inx 12205 1 Interestingly interestingly RB cord-010092-uftc8inx 12205 2 , , , cord-010092-uftc8inx 12205 3 MSC MSC NNP cord-010092-uftc8inx 12205 4 - - HYPH cord-010092-uftc8inx 12205 5 derived derive VBN cord-010092-uftc8inx 12205 6 compartment compartment NN cord-010092-uftc8inx 12205 7 could could MD cord-010092-uftc8inx 12205 8 be be VB cord-010092-uftc8inx 12205 9 used use VBN cord-010092-uftc8inx 12205 10 as as IN cord-010092-uftc8inx 12205 11 practical practical JJ cord-010092-uftc8inx 12205 12 tools tool NNS cord-010092-uftc8inx 12205 13 in in IN cord-010092-uftc8inx 12205 14 term term NN cord-010092-uftc8inx 12205 15 of of IN cord-010092-uftc8inx 12205 16 diagnosis diagnosis NN cord-010092-uftc8inx 12205 17 , , , cord-010092-uftc8inx 12205 18 follow follow VB cord-010092-uftc8inx 12205 19 up up RP cord-010092-uftc8inx 12205 20 , , , cord-010092-uftc8inx 12205 21 management management NN cord-010092-uftc8inx 12205 22 and and CC cord-010092-uftc8inx 12205 23 monitoring monitoring NN cord-010092-uftc8inx 12205 24 of of IN cord-010092-uftc8inx 12205 25 disease disease NN cord-010092-uftc8inx 12205 26 instead instead RB cord-010092-uftc8inx 12205 27 of of IN cord-010092-uftc8inx 12205 28 intact intact JJ cord-010092-uftc8inx 12205 29 MSCs msc NNS cord-010092-uftc8inx 12205 30 . . . cord-010092-uftc8inx 12206 1 Exosomes exosome NNS cord-010092-uftc8inx 12206 2 are be VBP cord-010092-uftc8inx 12206 3 kind kind RB cord-010092-uftc8inx 12206 4 of of RB cord-010092-uftc8inx 12206 5 extracellular extracellular JJ cord-010092-uftc8inx 12206 6 vesicles vesicle NNS cord-010092-uftc8inx 12206 7 ( ( -LRB- cord-010092-uftc8inx 12206 8 EVs ev NNS cord-010092-uftc8inx 12206 9 ) ) -RRB- cord-010092-uftc8inx 12206 10 characterized characterize VBD cord-010092-uftc8inx 12206 11 via via IN cord-010092-uftc8inx 12206 12 their -PRON- PRP$ cord-010092-uftc8inx 12206 13 size size NN cord-010092-uftc8inx 12206 14 and and CC cord-010092-uftc8inx 12206 15 releasing release VBG cord-010092-uftc8inx 12206 16 mechanism mechanism NN cord-010092-uftc8inx 12206 17 . . . cord-010092-uftc8inx 12207 1 Usually usually RB cord-010092-uftc8inx 12207 2 they -PRON- PRP cord-010092-uftc8inx 12207 3 defined define VBD cord-010092-uftc8inx 12207 4 as as IN cord-010092-uftc8inx 12207 5 less less JJR cord-010092-uftc8inx 12207 6 than than IN cord-010092-uftc8inx 12207 7 150 150 CD cord-010092-uftc8inx 12207 8 nm nm NN cord-010092-uftc8inx 12207 9 in in IN cord-010092-uftc8inx 12207 10 diameter diameter NN cord-010092-uftc8inx 12207 11 vesicles vesicle NNS cord-010092-uftc8inx 12207 12 . . . cord-010092-uftc8inx 12208 1 They -PRON- PRP cord-010092-uftc8inx 12208 2 secreted secrete VBD cord-010092-uftc8inx 12208 3 from from IN cord-010092-uftc8inx 12208 4 different different JJ cord-010092-uftc8inx 12208 5 cells cell NNS cord-010092-uftc8inx 12208 6 and and CC cord-010092-uftc8inx 12208 7 are be VBP cord-010092-uftc8inx 12208 8 also also RB cord-010092-uftc8inx 12208 9 found find VBN cord-010092-uftc8inx 12208 10 in in IN cord-010092-uftc8inx 12208 11 urine urine NN cord-010092-uftc8inx 12208 12 , , , cord-010092-uftc8inx 12208 13 blood blood NN cord-010092-uftc8inx 12208 14 , , , cord-010092-uftc8inx 12208 15 breast breast NN cord-010092-uftc8inx 12208 16 milk milk NN cord-010092-uftc8inx 12208 17 , , , cord-010092-uftc8inx 12208 18 cerebrospinal cerebrospinal JJ cord-010092-uftc8inx 12208 19 fluid fluid NN cord-010092-uftc8inx 12208 20 and and CC cord-010092-uftc8inx 12208 21 other other JJ cord-010092-uftc8inx 12208 22 body body NN cord-010092-uftc8inx 12208 23 fluids fluid NNS cord-010092-uftc8inx 12208 24 . . . cord-010092-uftc8inx 12209 1 Exosomes exosome NNS cord-010092-uftc8inx 12209 2 contain contain VBP cord-010092-uftc8inx 12209 3 genetic genetic JJ cord-010092-uftc8inx 12209 4 material material NN cord-010092-uftc8inx 12209 5 including include VBG cord-010092-uftc8inx 12209 6 DNA dna NN cord-010092-uftc8inx 12209 7 , , , cord-010092-uftc8inx 12209 8 mRNAs mrnas XX cord-010092-uftc8inx 12209 9 , , , cord-010092-uftc8inx 12209 10 microRNAs microRNAs NNPS cord-010092-uftc8inx 12209 11 ( ( -LRB- cord-010092-uftc8inx 12209 12 miRNAs miRNAs NNP cord-010092-uftc8inx 12209 13 ) ) -RRB- cord-010092-uftc8inx 12209 14 and and CC cord-010092-uftc8inx 12209 15 other other JJ cord-010092-uftc8inx 12209 16 biomolecules biomolecule NNS cord-010092-uftc8inx 12209 17 . . . cord-010092-uftc8inx 12210 1 miRNAs miRNAs NNP cord-010092-uftc8inx 12210 2 are be VBP cord-010092-uftc8inx 12210 3 single single JJ cord-010092-uftc8inx 12210 4 stranded strand VBN cord-010092-uftc8inx 12210 5 non non JJ cord-010092-uftc8inx 12210 6 - - JJ cord-010092-uftc8inx 12210 7 coding coding JJ cord-010092-uftc8inx 12210 8 RNAs rna NNS cord-010092-uftc8inx 12210 9 transcribed transcribe VBN cord-010092-uftc8inx 12210 10 from from IN cord-010092-uftc8inx 12210 11 DNA DNA NNP cord-010092-uftc8inx 12210 12 . . . cord-010092-uftc8inx 12211 1 Immature immature JJ cord-010092-uftc8inx 12211 2 miRNAs miRNAs NNP cord-010092-uftc8inx 12211 3 are be VBP cord-010092-uftc8inx 12211 4 subjected subject VBN cord-010092-uftc8inx 12211 5 to to IN cord-010092-uftc8inx 12211 6 two two CD cord-010092-uftc8inx 12211 7 known know VBN cord-010092-uftc8inx 12211 8 cleavages cleavage NNS cord-010092-uftc8inx 12211 9 to to TO cord-010092-uftc8inx 12211 10 modify modify VB cord-010092-uftc8inx 12211 11 to to TO cord-010092-uftc8inx 12211 12 mature mature VB cord-010092-uftc8inx 12211 13 miRNA miRNA NNP cord-010092-uftc8inx 12211 14 that that WDT cord-010092-uftc8inx 12211 15 involve involve VBP cord-010092-uftc8inx 12211 16 to to IN cord-010092-uftc8inx 12211 17 either either CC cord-010092-uftc8inx 12211 18 mRNA mRNA NNP cord-010092-uftc8inx 12211 19 degradation degradation NN cord-010092-uftc8inx 12211 20 and and CC cord-010092-uftc8inx 12211 21 gene gene NN cord-010092-uftc8inx 12211 22 expression expression NN cord-010092-uftc8inx 12211 23 process process NN cord-010092-uftc8inx 12211 24 or or CC cord-010092-uftc8inx 12211 25 cell cell NN cord-010092-uftc8inx 12211 26 - - HYPH cord-010092-uftc8inx 12211 27 cell cell NN cord-010092-uftc8inx 12211 28 interaction interaction NN cord-010092-uftc8inx 12211 29 and and CC cord-010092-uftc8inx 12211 30 communication communication NN cord-010092-uftc8inx 12211 31 via via IN cord-010092-uftc8inx 12211 32 secretion secretion NN cord-010092-uftc8inx 12211 33 as as IN cord-010092-uftc8inx 12211 34 the the DT cord-010092-uftc8inx 12211 35 part part NN cord-010092-uftc8inx 12211 36 of of IN cord-010092-uftc8inx 12211 37 exosomes exosome NNS cord-010092-uftc8inx 12211 38 . . . cord-010092-uftc8inx 12212 1 Aims aim VBZ cord-010092-uftc8inx 12212 2 : : : cord-010092-uftc8inx 12213 1 This this DT cord-010092-uftc8inx 12213 2 study study NN cord-010092-uftc8inx 12213 3 was be VBD cord-010092-uftc8inx 12213 4 aimed aim VBN cord-010092-uftc8inx 12213 5 to to TO cord-010092-uftc8inx 12213 6 discuss discuss VB cord-010092-uftc8inx 12213 7 some some DT cord-010092-uftc8inx 12213 8 aspects aspect NNS cord-010092-uftc8inx 12213 9 of of IN cord-010092-uftc8inx 12213 10 exosomal exosomal JJ cord-010092-uftc8inx 12213 11 microRNAs micrornas RB cord-010092-uftc8inx 12213 12 derived derive VBD cord-010092-uftc8inx 12213 13 from from IN cord-010092-uftc8inx 12213 14 MSCs msc NNS cord-010092-uftc8inx 12213 15 in in IN cord-010092-uftc8inx 12213 16 progression progression NN cord-010092-uftc8inx 12213 17 , , , cord-010092-uftc8inx 12213 18 diagnosis diagnosis NN cord-010092-uftc8inx 12213 19 and and CC cord-010092-uftc8inx 12213 20 treatment treatment NN cord-010092-uftc8inx 12213 21 of of IN cord-010092-uftc8inx 12213 22 some some DT cord-010092-uftc8inx 12213 23 diseases disease NNS cord-010092-uftc8inx 12213 24 . . . cord-010092-uftc8inx 12214 1 Methods method NNS cord-010092-uftc8inx 12214 2 : : : cord-010092-uftc8inx 12215 1 Different different JJ cord-010092-uftc8inx 12215 2 scientific scientific JJ cord-010092-uftc8inx 12215 3 data data NN cord-010092-uftc8inx 12215 4 bases basis NNS cord-010092-uftc8inx 12215 5 including include VBG cord-010092-uftc8inx 12215 6 PubMed PubMed NNP cord-010092-uftc8inx 12215 7 , , , cord-010092-uftc8inx 12215 8 Google Google NNP cord-010092-uftc8inx 12215 9 scholar scholar NN cord-010092-uftc8inx 12215 10 and and CC cord-010092-uftc8inx 12215 11 Scopus Scopus NNP cord-010092-uftc8inx 12215 12 were be VBD cord-010092-uftc8inx 12215 13 used use VBN cord-010092-uftc8inx 12215 14 to to TO cord-010092-uftc8inx 12215 15 find find VB cord-010092-uftc8inx 12215 16 and and CC cord-010092-uftc8inx 12215 17 review review VB cord-010092-uftc8inx 12215 18 related relate VBN cord-010092-uftc8inx 12215 19 articles article NNS cord-010092-uftc8inx 12215 20 . . . cord-010092-uftc8inx 12216 1 Results result NNS cord-010092-uftc8inx 12216 2 : : : cord-010092-uftc8inx 12216 3 EVs ev NNS cord-010092-uftc8inx 12216 4 play play VBP cord-010092-uftc8inx 12216 5 important important JJ cord-010092-uftc8inx 12216 6 role role NN cord-010092-uftc8inx 12216 7 either either CC cord-010092-uftc8inx 12216 8 in in IN cord-010092-uftc8inx 12216 9 intercellular intercellular JJ cord-010092-uftc8inx 12216 10 communication communication NN cord-010092-uftc8inx 12216 11 related relate VBN cord-010092-uftc8inx 12216 12 to to IN cord-010092-uftc8inx 12216 13 pathological pathological JJ cord-010092-uftc8inx 12216 14 and and CC cord-010092-uftc8inx 12216 15 physiological physiological JJ cord-010092-uftc8inx 12216 16 situation situation NN cord-010092-uftc8inx 12216 17 or or CC cord-010092-uftc8inx 12216 18 intracellular intracellular JJ cord-010092-uftc8inx 12216 19 communication communication NN cord-010092-uftc8inx 12216 20 , , , cord-010092-uftc8inx 12216 21 angiogenesis angiogenesis NN cord-010092-uftc8inx 12216 22 , , , cord-010092-uftc8inx 12216 23 immune immune JJ cord-010092-uftc8inx 12216 24 system system NN cord-010092-uftc8inx 12216 25 modulation modulation NN cord-010092-uftc8inx 12216 26 and and CC cord-010092-uftc8inx 12216 27 metastasis metastasis NN cord-010092-uftc8inx 12216 28 progression progression NN cord-010092-uftc8inx 12216 29 . . . cord-010092-uftc8inx 12217 1 miRNAs miRNAs NNP cord-010092-uftc8inx 12217 2 could could MD cord-010092-uftc8inx 12217 3 regulate regulate VB cord-010092-uftc8inx 12217 4 expression expression NN cord-010092-uftc8inx 12217 5 of of IN cord-010092-uftc8inx 12217 6 multiple multiple NN cord-010092-uftc8inx 12217 7 mRNAs mrnas ADD cord-010092-uftc8inx 12218 1 then then RB cord-010092-uftc8inx 12218 2 they -PRON- PRP cord-010092-uftc8inx 12218 3 play play VBP cord-010092-uftc8inx 12218 4 important important JJ cord-010092-uftc8inx 12218 5 role role NN cord-010092-uftc8inx 12218 6 in in IN cord-010092-uftc8inx 12218 7 different different JJ cord-010092-uftc8inx 12218 8 biological biological JJ cord-010092-uftc8inx 12218 9 processes process NNS cord-010092-uftc8inx 12218 10 and and CC cord-010092-uftc8inx 12218 11 contribute contribute VB cord-010092-uftc8inx 12218 12 cell cell NN cord-010092-uftc8inx 12218 13 - - HYPH cord-010092-uftc8inx 12218 14 cell cell NN cord-010092-uftc8inx 12218 15 interaction interaction NN cord-010092-uftc8inx 12218 16 as as RB cord-010092-uftc8inx 12218 17 well well RB cord-010092-uftc8inx 12218 18 as as IN cord-010092-uftc8inx 12218 19 influence influence NN cord-010092-uftc8inx 12218 20 in in IN cord-010092-uftc8inx 12218 21 the the DT cord-010092-uftc8inx 12218 22 progression progression NN cord-010092-uftc8inx 12218 23 of of IN cord-010092-uftc8inx 12218 24 different different JJ cord-010092-uftc8inx 12218 25 disease disease NN cord-010092-uftc8inx 12218 26 . . . cord-010092-uftc8inx 12219 1 Exosomal Exosomal NNP cord-010092-uftc8inx 12219 2 miRNA miRNA NNP cord-010092-uftc8inx 12219 3 - - HYPH cord-010092-uftc8inx 12219 4 derived derive VBN cord-010092-uftc8inx 12219 5 MSCs msc NNS cord-010092-uftc8inx 12219 6 are be VBP cord-010092-uftc8inx 12219 7 involved involve VBN cord-010092-uftc8inx 12219 8 in in IN cord-010092-uftc8inx 12219 9 cancer cancer NN cord-010092-uftc8inx 12219 10 procession procession NN cord-010092-uftc8inx 12219 11 , , , cord-010092-uftc8inx 12219 12 tumor tumor NN cord-010092-uftc8inx 12219 13 growth growth NN cord-010092-uftc8inx 12219 14 , , , cord-010092-uftc8inx 12219 15 angiogenesis angiogenesis NN cord-010092-uftc8inx 12219 16 and and CC cord-010092-uftc8inx 12219 17 metastasis metastasis NN cord-010092-uftc8inx 12219 18 . . . cord-010092-uftc8inx 12220 1 They -PRON- PRP cord-010092-uftc8inx 12220 2 are be VBP cord-010092-uftc8inx 12220 3 used use VBN cord-010092-uftc8inx 12220 4 as as IN cord-010092-uftc8inx 12220 5 diagnosis diagnosis NN cord-010092-uftc8inx 12220 6 and and CC cord-010092-uftc8inx 12220 7 therapeutic therapeutic JJ cord-010092-uftc8inx 12220 8 tools tool NNS cord-010092-uftc8inx 12220 9 to to TO cord-010092-uftc8inx 12220 10 treat treat VB cord-010092-uftc8inx 12220 11 different different JJ cord-010092-uftc8inx 12220 12 diseases disease NNS cord-010092-uftc8inx 12220 13 such such JJ cord-010092-uftc8inx 12220 14 as as IN cord-010092-uftc8inx 12220 15 renal renal JJ cord-010092-uftc8inx 12220 16 failure failure NN cord-010092-uftc8inx 12220 17 , , , cord-010092-uftc8inx 12220 18 liver liver NN cord-010092-uftc8inx 12220 19 fibrosis fibrosis NN cord-010092-uftc8inx 12220 20 , , , cord-010092-uftc8inx 12220 21 myocardial myocardial JJ cord-010092-uftc8inx 12220 22 infarction infarction NN cord-010092-uftc8inx 12220 23 . . . cord-010092-uftc8inx 12221 1 Summary Summary NNP cord-010092-uftc8inx 12221 2 / / SYM cord-010092-uftc8inx 12221 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 12221 4 : : : cord-010092-uftc8inx 12221 5 Due due IN cord-010092-uftc8inx 12221 6 to to IN cord-010092-uftc8inx 12221 7 controversial controversial JJ cord-010092-uftc8inx 12221 8 aspect aspect NN cord-010092-uftc8inx 12221 9 of of IN cord-010092-uftc8inx 12221 10 using use VBG cord-010092-uftc8inx 12221 11 of of IN cord-010092-uftc8inx 12221 12 intact intact JJ cord-010092-uftc8inx 12221 13 MSCs mscs NN cord-010092-uftc8inx 12221 14 especially especially RB cord-010092-uftc8inx 12221 15 during during IN cord-010092-uftc8inx 12221 16 remission remission NN cord-010092-uftc8inx 12221 17 or or CC cord-010092-uftc8inx 12221 18 in in IN cord-010092-uftc8inx 12221 19 presence presence NN cord-010092-uftc8inx 12221 20 of of IN cord-010092-uftc8inx 12221 21 tumor tumor NN cord-010092-uftc8inx 12221 22 , , , cord-010092-uftc8inx 12221 23 MSC MSC NNP cord-010092-uftc8inx 12221 24 - - HYPH cord-010092-uftc8inx 12221 25 derived derive VBN cord-010092-uftc8inx 12221 26 exosome exosome NN cord-010092-uftc8inx 12221 27 could could MD cord-010092-uftc8inx 12221 28 be be VB cord-010092-uftc8inx 12221 29 used use VBN cord-010092-uftc8inx 12221 30 as as IN cord-010092-uftc8inx 12221 31 practical practical JJ cord-010092-uftc8inx 12221 32 tools tool NNS cord-010092-uftc8inx 12221 33 in in IN cord-010092-uftc8inx 12221 34 term term NN cord-010092-uftc8inx 12221 35 of of IN cord-010092-uftc8inx 12221 36 diagnosis diagnosis NN cord-010092-uftc8inx 12221 37 , , , cord-010092-uftc8inx 12221 38 follow follow VB cord-010092-uftc8inx 12221 39 up up RP cord-010092-uftc8inx 12221 40 , , , cord-010092-uftc8inx 12221 41 management management NN cord-010092-uftc8inx 12221 42 and and CC cord-010092-uftc8inx 12221 43 monitoring monitoring NN cord-010092-uftc8inx 12221 44 of of IN cord-010092-uftc8inx 12221 45 disease disease NN cord-010092-uftc8inx 12221 46 instead instead RB cord-010092-uftc8inx 12221 47 of of IN cord-010092-uftc8inx 12221 48 intact intact JJ cord-010092-uftc8inx 12221 49 MSCs msc NNS cord-010092-uftc8inx 12221 50 . . . cord-010092-uftc8inx 12221 51 _SP cord-010092-uftc8inx 12222 1 Aims aim VBZ cord-010092-uftc8inx 12222 2 : : : cord-010092-uftc8inx 12223 1 The the DT cord-010092-uftc8inx 12223 2 aim aim NN cord-010092-uftc8inx 12223 3 of of IN cord-010092-uftc8inx 12223 4 study study NN cord-010092-uftc8inx 12223 5 try try VBP cord-010092-uftc8inx 12223 6 to to TO cord-010092-uftc8inx 12223 7 use use VB cord-010092-uftc8inx 12223 8 SYBR SYBR NNP cord-010092-uftc8inx 12223 9 Green Green NNP cord-010092-uftc8inx 12224 1 I -PRON- PRP cord-010092-uftc8inx 12224 2 based base VBD cord-010092-uftc8inx 12224 3 real real JJ cord-010092-uftc8inx 12224 4 - - HYPH cord-010092-uftc8inx 12224 5 time time NN cord-010092-uftc8inx 12224 6 PCR PCR NNP cord-010092-uftc8inx 12224 7 to to TO cord-010092-uftc8inx 12224 8 identify identify VB cord-010092-uftc8inx 12224 9 homozygous homozygous JJ cord-010092-uftc8inx 12224 10 , , , cord-010092-uftc8inx 12224 11 heterozygous heterozygous JJ cord-010092-uftc8inx 12224 12 , , , cord-010092-uftc8inx 12224 13 gene gene NN cord-010092-uftc8inx 12224 14 deletion deletion NN cord-010092-uftc8inx 12224 15 or or CC cord-010092-uftc8inx 12224 16 wild wild JJ cord-010092-uftc8inx 12224 17 type type NN cord-010092-uftc8inx 12224 18 for for IN cord-010092-uftc8inx 12224 19 RhD RhD NNP cord-010092-uftc8inx 12224 20 exon exon NNP cord-010092-uftc8inx 12224 21 1 1 CD cord-010092-uftc8inx 12224 22 , , , cord-010092-uftc8inx 12224 23 5 5 CD cord-010092-uftc8inx 12224 24 , , , cord-010092-uftc8inx 12224 25 10 10 CD cord-010092-uftc8inx 12224 26 and and CC cord-010092-uftc8inx 12224 27 1227A. 1227a. CD cord-010092-uftc8inx 12224 28 Methods method NNS cord-010092-uftc8inx 12224 29 : : : cord-010092-uftc8inx 12224 30 For for IN cord-010092-uftc8inx 12224 31 this this DT cord-010092-uftc8inx 12224 32 study study NN cord-010092-uftc8inx 12224 33 , , , cord-010092-uftc8inx 12224 34 we -PRON- PRP cord-010092-uftc8inx 12224 35 used use VBD cord-010092-uftc8inx 12224 36 real real JJ cord-010092-uftc8inx 12224 37 - - HYPH cord-010092-uftc8inx 12224 38 time time NN cord-010092-uftc8inx 12224 39 PCR PCR NNP cord-010092-uftc8inx 12224 40 with with IN cord-010092-uftc8inx 12224 41 high high JJ cord-010092-uftc8inx 12224 42 resolution resolution NN cord-010092-uftc8inx 12224 43 melting melting NN cord-010092-uftc8inx 12224 44 curve curve NN cord-010092-uftc8inx 12224 45 mode mode NN cord-010092-uftc8inx 12224 46 , , , cord-010092-uftc8inx 12224 47 and and CC cord-010092-uftc8inx 12224 48 Matrix Matrix NNP cord-010092-uftc8inx 12224 49 mix mix NN cord-010092-uftc8inx 12224 50 containing contain VBG cord-010092-uftc8inx 12225 1 SYBR SYBR NNP cord-010092-uftc8inx 12225 2 - - HYPH cord-010092-uftc8inx 12225 3 Green Green NNP cord-010092-uftc8inx 12225 4 I -PRON- PRP cord-010092-uftc8inx 12225 5 were be VBD cord-010092-uftc8inx 12225 6 used use VBN cord-010092-uftc8inx 12225 7 for for IN cord-010092-uftc8inx 12225 8 sequence sequence NN cord-010092-uftc8inx 12225 9 specific specific JJ cord-010092-uftc8inx 12225 10 primers primer NNS cord-010092-uftc8inx 12225 11 of of IN cord-010092-uftc8inx 12225 12 1227 1227 CD cord-010092-uftc8inx 12225 13 G g NN cord-010092-uftc8inx 12226 1 > > XX cord-010092-uftc8inx 12227 1 A A NNP cord-010092-uftc8inx 12227 2 and and CC cord-010092-uftc8inx 12227 3 RhD rhd NN cord-010092-uftc8inx 12227 4 exon exon NNP cord-010092-uftc8inx 12227 5 1 1 CD cord-010092-uftc8inx 12227 6 , , , cord-010092-uftc8inx 12227 7 5 5 CD cord-010092-uftc8inx 12227 8 , , , cord-010092-uftc8inx 12227 9 10 10 CD cord-010092-uftc8inx 12227 10 . . . cord-010092-uftc8inx 12228 1 Samples sample NNS cord-010092-uftc8inx 12228 2 with with IN cord-010092-uftc8inx 12228 3 RhD rhd NN cord-010092-uftc8inx 12228 4 gene gene NN cord-010092-uftc8inx 12228 5 deletion deletion NN cord-010092-uftc8inx 12228 6 homozygous homozygous NNP cord-010092-uftc8inx 12228 7 / / SYM cord-010092-uftc8inx 12228 8 heterozygous heterozygous JJ cord-010092-uftc8inx 12228 9 , , , cord-010092-uftc8inx 12228 10 1227 1227 CD cord-010092-uftc8inx 12228 11 G g NN cord-010092-uftc8inx 12228 12 > > XX cord-010092-uftc8inx 12229 1 A a DT cord-010092-uftc8inx 12229 2 heterozygous heterozygous JJ cord-010092-uftc8inx 12229 3 with with IN cord-010092-uftc8inx 12229 4 RhD RhD NNP cord-010092-uftc8inx 12229 5 gene gene NN cord-010092-uftc8inx 12229 6 deletion deletion NN cord-010092-uftc8inx 12229 7 and and CC cord-010092-uftc8inx 12229 8 normal normal JJ cord-010092-uftc8inx 12229 9 RhD rhd NN cord-010092-uftc8inx 12229 10 , , , cord-010092-uftc8inx 12229 11 normal normal JJ cord-010092-uftc8inx 12229 12 RhD RhD NNP cord-010092-uftc8inx 12229 13 homozygous homozygous JJ cord-010092-uftc8inx 12229 14 / / SYM cord-010092-uftc8inx 12229 15 heterozygous heterozygous JJ cord-010092-uftc8inx 12229 16 and and CC cord-010092-uftc8inx 12229 17 RhD1-RhCE(2 RhD1-RhCE(2 NNP cord-010092-uftc8inx 12229 18 - - HYPH cord-010092-uftc8inx 12229 19 9)-RhD10 9)-rhd10 CD cord-010092-uftc8inx 12229 20 homozygous homozygous JJ cord-010092-uftc8inx 12229 21 / / SYM cord-010092-uftc8inx 12229 22 heterozygous heterozygous JJ cord-010092-uftc8inx 12229 23 were be VBD cord-010092-uftc8inx 12229 24 enrolled enrol VBN cord-010092-uftc8inx 12229 25 in in IN cord-010092-uftc8inx 12229 26 our -PRON- PRP$ cord-010092-uftc8inx 12229 27 study study NN cord-010092-uftc8inx 12229 28 . . . cord-010092-uftc8inx 12230 1 All all DT cord-010092-uftc8inx 12230 2 samples sample NNS cord-010092-uftc8inx 12230 3 were be VBD cord-010092-uftc8inx 12230 4 screened screen VBN cord-010092-uftc8inx 12230 5 using use VBG cord-010092-uftc8inx 12230 6 RhD RhD NNP cord-010092-uftc8inx 12230 7 exon exon NN cord-010092-uftc8inx 12230 8 genotyping genotyping NN cord-010092-uftc8inx 12230 9 , , , cord-010092-uftc8inx 12230 10 Sanger Sanger NNP cord-010092-uftc8inx 12230 11 sequencing sequencing NN cord-010092-uftc8inx 12230 12 and and CC cord-010092-uftc8inx 12230 13 Rhesus Rhesus NNP cord-010092-uftc8inx 12230 14 box box NN cord-010092-uftc8inx 12230 15 analysis analysis NN cord-010092-uftc8inx 12230 16 . . . cord-010092-uftc8inx 12231 1 Concentration concentration NN cord-010092-uftc8inx 12231 2 and and CC cord-010092-uftc8inx 12231 3 mass mass NN cord-010092-uftc8inx 12231 4 of of IN cord-010092-uftc8inx 12231 5 DNA dna NN cord-010092-uftc8inx 12231 6 samples sample NNS cord-010092-uftc8inx 12231 7 were be VBD cord-010092-uftc8inx 12231 8 1 1 CD cord-010092-uftc8inx 12231 9 in in IN cord-010092-uftc8inx 12231 10 alleles allele NNS cord-010092-uftc8inx 12231 11 of of IN cord-010092-uftc8inx 12231 12 normal normal JJ cord-010092-uftc8inx 12231 13 RhD rhd NN cord-010092-uftc8inx 12231 14 / / SYM cord-010092-uftc8inx 12231 15 RhD RhD NNP cord-010092-uftc8inx 12231 16 gene gene NN cord-010092-uftc8inx 12231 17 deletion deletion NN cord-010092-uftc8inx 12231 18 . . . cord-010092-uftc8inx 12232 1 The the DT cord-010092-uftc8inx 12232 2 Tm Tm NNP cord-010092-uftc8inx 12232 3 ratio ratio NN cord-010092-uftc8inx 12232 4 of of IN cord-010092-uftc8inx 12232 5 RhD RhD NNP cord-010092-uftc8inx 12232 6 exon exon NNP cord-010092-uftc8inx 12232 7 1 1 CD cord-010092-uftc8inx 12232 8 ( ( -LRB- cord-010092-uftc8inx 12232 9 87 87 CD cord-010092-uftc8inx 12232 10 ° ° NN cord-010092-uftc8inx 12232 11 C c NN cord-010092-uftc8inx 12232 12 ) ) -RRB- cord-010092-uftc8inx 12232 13 to to IN cord-010092-uftc8inx 12232 14 internal internal JJ cord-010092-uftc8inx 12232 15 control control NN cord-010092-uftc8inx 12232 16 ( ( -LRB- cord-010092-uftc8inx 12232 17 77 77 CD cord-010092-uftc8inx 12232 18 ° ° NN cord-010092-uftc8inx 12232 19 C C NNP cord-010092-uftc8inx 12232 20 ) ) -RRB- cord-010092-uftc8inx 12232 21 were be VBD cord-010092-uftc8inx 12232 22 2.33 2.33 CD cord-010092-uftc8inx 12232 23 in in IN cord-010092-uftc8inx 12232 24 alleles allele NNS cord-010092-uftc8inx 12232 25 of of IN cord-010092-uftc8inx 12232 26 normal normal JJ cord-010092-uftc8inx 12232 27 RhD rhd NN cord-010092-uftc8inx 12232 28 / / SYM cord-010092-uftc8inx 12232 29 RhD1-RhCE(2 RhD1-RhCE(2 NNP cord-010092-uftc8inx 12232 30 - - HYPH cord-010092-uftc8inx 12232 31 9)-RhD10 9)-rhd10 CD cord-010092-uftc8inx 12232 32 , , , cord-010092-uftc8inx 12232 33 2.09 2.09 CD cord-010092-uftc8inx 12232 34 - - SYM cord-010092-uftc8inx 12232 35 2.21 2.21 CD cord-010092-uftc8inx 12232 36 in in IN cord-010092-uftc8inx 12232 37 alleles allele NNS cord-010092-uftc8inx 12232 38 of of IN cord-010092-uftc8inx 12232 39 RhD RhD NNP cord-010092-uftc8inx 12232 40 gene gene NN cord-010092-uftc8inx 12232 41 deletion deletion NN cord-010092-uftc8inx 12232 42 / / SYM cord-010092-uftc8inx 12232 43 normal normal JJ cord-010092-uftc8inx 12232 44 RhD rhd NN cord-010092-uftc8inx 12232 45 , , , cord-010092-uftc8inx 12232 46 2.53 2.53 CD cord-010092-uftc8inx 12232 47 - - SYM cord-010092-uftc8inx 12232 48 2.66 2.66 CD cord-010092-uftc8inx 12232 49 in in IN cord-010092-uftc8inx 12232 50 alleles allele NNS cord-010092-uftc8inx 12232 51 of of IN cord-010092-uftc8inx 12232 52 normal normal JJ cord-010092-uftc8inx 12232 53 RhD rhd NN cord-010092-uftc8inx 12232 54 and and CC cord-010092-uftc8inx 12232 55 < < XX cord-010092-uftc8inx 12232 56 0.1 0.1 CD cord-010092-uftc8inx 12232 57 alleles allele NNS cord-010092-uftc8inx 12232 58 of of IN cord-010092-uftc8inx 12232 59 RhD RhD NNP cord-010092-uftc8inx 12232 60 gene gene NN cord-010092-uftc8inx 12232 61 deletion deletion NN cord-010092-uftc8inx 12232 62 . . . cord-010092-uftc8inx 12233 1 The the DT cord-010092-uftc8inx 12233 2 Tm Tm NNP cord-010092-uftc8inx 12233 3 ratio ratio NN cord-010092-uftc8inx 12233 4 of of IN cord-010092-uftc8inx 12233 5 RhD RhD NNP cord-010092-uftc8inx 12233 6 exon exon NNP cord-010092-uftc8inx 12233 7 10 10 CD cord-010092-uftc8inx 12233 8 ( ( -LRB- cord-010092-uftc8inx 12233 9 81 81 CD cord-010092-uftc8inx 12233 10 ° ° NN cord-010092-uftc8inx 12233 11 C c NN cord-010092-uftc8inx 12233 12 ) ) -RRB- cord-010092-uftc8inx 12233 13 to to IN cord-010092-uftc8inx 12233 14 internal internal JJ cord-010092-uftc8inx 12233 15 control control NN cord-010092-uftc8inx 12233 16 ( ( -LRB- cord-010092-uftc8inx 12233 17 77 77 CD cord-010092-uftc8inx 12233 18 ° ° NN cord-010092-uftc8inx 12233 19 C C NNP cord-010092-uftc8inx 12233 20 ) ) -RRB- cord-010092-uftc8inx 12233 21 were be VBD cord-010092-uftc8inx 12233 22 3.35 3.35 CD cord-010092-uftc8inx 12233 23 in in IN cord-010092-uftc8inx 12233 24 alleles allele NNS cord-010092-uftc8inx 12233 25 of of IN cord-010092-uftc8inx 12233 26 normal normal JJ cord-010092-uftc8inx 12233 27 RhD rhd NN cord-010092-uftc8inx 12233 28 / / SYM cord-010092-uftc8inx 12233 29 RhD1-RhCE(2 RhD1-RhCE(2 NNP cord-010092-uftc8inx 12233 30 - - HYPH cord-010092-uftc8inx 12233 31 9)-RhD10 9)-rhd10 CD cord-010092-uftc8inx 12233 32 , , , cord-010092-uftc8inx 12233 33 4.29 4.29 CD cord-010092-uftc8inx 12233 34 - - SYM cord-010092-uftc8inx 12233 35 4.39 4.39 CD cord-010092-uftc8inx 12233 36 in in IN cord-010092-uftc8inx 12233 37 alleles allele NNS cord-010092-uftc8inx 12233 38 of of IN cord-010092-uftc8inx 12233 39 RhD RhD NNP cord-010092-uftc8inx 12233 40 gene gene NN cord-010092-uftc8inx 12233 41 deletion deletion NN cord-010092-uftc8inx 12233 42 / / SYM cord-010092-uftc8inx 12233 43 normal normal JJ cord-010092-uftc8inx 12233 44 RhD rhd NN cord-010092-uftc8inx 12233 45 , , , cord-010092-uftc8inx 12233 46 4.67 4.67 CD cord-010092-uftc8inx 12233 47 - - SYM cord-010092-uftc8inx 12233 48 6.10 6.10 CD cord-010092-uftc8inx 12233 49 in in IN cord-010092-uftc8inx 12233 50 alleles allele NNS cord-010092-uftc8inx 12233 51 of of IN cord-010092-uftc8inx 12233 52 normal normal JJ cord-010092-uftc8inx 12233 53 RhD rhd NN cord-010092-uftc8inx 12233 54 and and CC cord-010092-uftc8inx 12233 55 < < XX cord-010092-uftc8inx 12233 56 0.1 0.1 CD cord-010092-uftc8inx 12233 57 alleles allele NNS cord-010092-uftc8inx 12233 58 of of IN cord-010092-uftc8inx 12233 59 RhD RhD NNP cord-010092-uftc8inx 12233 60 gene gene NN cord-010092-uftc8inx 12233 61 deletion deletion NN cord-010092-uftc8inx 12233 62 . . . cord-010092-uftc8inx 12234 1 The the DT cord-010092-uftc8inx 12234 2 Tm Tm NNP cord-010092-uftc8inx 12234 3 ratio ratio NN cord-010092-uftc8inx 12234 4 of of IN cord-010092-uftc8inx 12234 5 RhD RhD NNP cord-010092-uftc8inx 12234 6 exon exon NNP cord-010092-uftc8inx 12234 7 5 5 CD cord-010092-uftc8inx 12234 8 ( ( -LRB- cord-010092-uftc8inx 12234 9 81 81 CD cord-010092-uftc8inx 12234 10 ° ° NN cord-010092-uftc8inx 12234 11 C c NN cord-010092-uftc8inx 12234 12 ) ) -RRB- cord-010092-uftc8inx 12234 13 to to IN cord-010092-uftc8inx 12234 14 internal internal JJ cord-010092-uftc8inx 12234 15 control control NN cord-010092-uftc8inx 12234 16 ( ( -LRB- cord-010092-uftc8inx 12234 17 77 77 CD cord-010092-uftc8inx 12234 18 ° ° NN cord-010092-uftc8inx 12234 19 C C NNP cord-010092-uftc8inx 12234 20 ) ) -RRB- cord-010092-uftc8inx 12234 21 were be VBD cord-010092-uftc8inx 12234 22 3.64 3.64 CD cord-010092-uftc8inx 12234 23 in in IN cord-010092-uftc8inx 12234 24 alleles allele NNS cord-010092-uftc8inx 12234 25 of of IN cord-010092-uftc8inx 12234 26 normal normal JJ cord-010092-uftc8inx 12234 27 RhD rhd NN cord-010092-uftc8inx 12234 28 / / SYM cord-010092-uftc8inx 12234 29 RhD1-RhCE(2 RhD1-RhCE(2 NNP cord-010092-uftc8inx 12234 30 - - HYPH cord-010092-uftc8inx 12234 31 9)-RhD10 9)-rhd10 CD cord-010092-uftc8inx 12234 32 , , , cord-010092-uftc8inx 12234 33 2.49 2.49 CD cord-010092-uftc8inx 12234 34 in in IN cord-010092-uftc8inx 12234 35 alleles allele NNS cord-010092-uftc8inx 12234 36 of of IN cord-010092-uftc8inx 12234 37 RhD RhD NNP cord-010092-uftc8inx 12234 38 gene gene NN cord-010092-uftc8inx 12234 39 deletion deletion NN cord-010092-uftc8inx 12234 40 / / SYM cord-010092-uftc8inx 12234 41 RhD1-RhCE(2 RhD1-RhCE(2 NNP cord-010092-uftc8inx 12234 42 - - HYPH cord-010092-uftc8inx 12234 43 9)-RhD10 9)-rhd10 CD cord-010092-uftc8inx 12234 44 3.47 3.47 CD cord-010092-uftc8inx 12234 45 - - SYM cord-010092-uftc8inx 12234 46 3.59 3.59 CD cord-010092-uftc8inx 12234 47 in in IN cord-010092-uftc8inx 12234 48 alleles allele NNS cord-010092-uftc8inx 12234 49 of of IN cord-010092-uftc8inx 12234 50 RhD RhD NNP cord-010092-uftc8inx 12234 51 gene gene NN cord-010092-uftc8inx 12234 52 deletion deletion NN cord-010092-uftc8inx 12234 53 / / SYM cord-010092-uftc8inx 12234 54 normal normal JJ cord-010092-uftc8inx 12234 55 RhD rhd NN cord-010092-uftc8inx 12234 56 , , , cord-010092-uftc8inx 12234 57 3.97 3.97 CD cord-010092-uftc8inx 12234 58 - - SYM cord-010092-uftc8inx 12234 59 4.77 4.77 CD cord-010092-uftc8inx 12234 60 in in IN cord-010092-uftc8inx 12234 61 alleles allele NNS cord-010092-uftc8inx 12234 62 of of IN cord-010092-uftc8inx 12234 63 normal normal JJ cord-010092-uftc8inx 12234 64 RhD rhd NN cord-010092-uftc8inx 12234 65 and and CC cord-010092-uftc8inx 12234 66 < < XX cord-010092-uftc8inx 12234 67 0.1 0.1 CD cord-010092-uftc8inx 12234 68 alleles allele NNS cord-010092-uftc8inx 12234 69 of of IN cord-010092-uftc8inx 12234 70 RhD RhD NNP cord-010092-uftc8inx 12234 71 gene gene NN cord-010092-uftc8inx 12234 72 deletion deletion NN cord-010092-uftc8inx 12234 73 . . . cord-010092-uftc8inx 12235 1 Summary Summary NNP cord-010092-uftc8inx 12235 2 / / SYM cord-010092-uftc8inx 12235 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 12235 4 : : : cord-010092-uftc8inx 12236 1 Using use VBG cord-010092-uftc8inx 12236 2 the the DT cord-010092-uftc8inx 12236 3 Tm Tm NNP cord-010092-uftc8inx 12236 4 Ratio Ratio NNP cord-010092-uftc8inx 12236 5 of of IN cord-010092-uftc8inx 12236 6 sequence sequence NN cord-010092-uftc8inx 12236 7 specific specific JJ cord-010092-uftc8inx 12236 8 primers primer NNS cord-010092-uftc8inx 12236 9 to to IN cord-010092-uftc8inx 12236 10 internal internal JJ cord-010092-uftc8inx 12236 11 control control NN cord-010092-uftc8inx 12236 12 is be VBZ cord-010092-uftc8inx 12236 13 an an DT cord-010092-uftc8inx 12236 14 effective effective JJ cord-010092-uftc8inx 12236 15 way way NN cord-010092-uftc8inx 12236 16 to to TO cord-010092-uftc8inx 12236 17 detect detect VB cord-010092-uftc8inx 12236 18 the the DT cord-010092-uftc8inx 12236 19 RhD RhD NNP cord-010092-uftc8inx 12236 20 gene gene NN cord-010092-uftc8inx 12236 21 deletion deletion NN cord-010092-uftc8inx 12236 22 or or CC cord-010092-uftc8inx 12236 23 RhD rhd NN cord-010092-uftc8inx 12236 24 Weak Weak NNP cord-010092-uftc8inx 12236 25 D D NNP cord-010092-uftc8inx 12236 26 Types Types NNP cord-010092-uftc8inx 12236 27 1 1 CD cord-010092-uftc8inx 12236 28 , , , cord-010092-uftc8inx 12236 29 2 2 CD cord-010092-uftc8inx 12236 30 and and CC cord-010092-uftc8inx 12236 31 3 3 CD cord-010092-uftc8inx 12236 32 not not RB cord-010092-uftc8inx 12236 33 detected detect VBN cord-010092-uftc8inx 12236 34 " " '' cord-010092-uftc8inx 12236 35 ) ) -RRB- cord-010092-uftc8inx 12236 36 were be VBD cord-010092-uftc8inx 12236 37 tested test VBN cord-010092-uftc8inx 12236 38 with with IN cord-010092-uftc8inx 12236 39 a a DT cord-010092-uftc8inx 12236 40 method method NN cord-010092-uftc8inx 12236 41 based base VBN cord-010092-uftc8inx 12236 42 on on IN cord-010092-uftc8inx 12236 43 Next Next NNP cord-010092-uftc8inx 12236 44 Generation Generation NNP cord-010092-uftc8inx 12236 45 Sequencing Sequencing NNP cord-010092-uftc8inx 12236 46 ( ( -LRB- cord-010092-uftc8inx 12236 47 NGS NGS NNP cord-010092-uftc8inx 12236 48 ) ) -RRB- cord-010092-uftc8inx 12236 49 using use VBG cord-010092-uftc8inx 12236 50 the the DT cord-010092-uftc8inx 12236 51 Illumina Illumina NNP cord-010092-uftc8inx 12236 52 MiSeq MiSeq NNP cord-010092-uftc8inx 12236 53 platform platform NN cord-010092-uftc8inx 12236 54 to to TO cord-010092-uftc8inx 12236 55 detect detect VB cord-010092-uftc8inx 12236 56 a a DT cord-010092-uftc8inx 12236 57 possible possible JJ cord-010092-uftc8inx 12236 58 RHD rhd NN cord-010092-uftc8inx 12236 59 variant variant NN cord-010092-uftc8inx 12236 60 not not RB cord-010092-uftc8inx 12236 61 interrogated interrogate VBN cord-010092-uftc8inx 12236 62 by by IN cord-010092-uftc8inx 12236 63 ID ID NNP cord-010092-uftc8inx 12236 64 RHD RHD NNP cord-010092-uftc8inx 12236 65 XT XT NNP cord-010092-uftc8inx 12236 66 . . . cord-010092-uftc8inx 12237 1 Results result NNS cord-010092-uftc8inx 12237 2 : : : cord-010092-uftc8inx 12238 1 In in IN cord-010092-uftc8inx 12238 2 total total JJ cord-010092-uftc8inx 12238 3 583 583 CD cord-010092-uftc8inx 12238 4 DNA dna NN cord-010092-uftc8inx 12238 5 samples sample NNS cord-010092-uftc8inx 12238 6 were be VBD cord-010092-uftc8inx 12238 7 tested test VBN cord-010092-uftc8inx 12238 8 in in IN cord-010092-uftc8inx 12238 9 87 87 CD cord-010092-uftc8inx 12238 10 pools pool NNS cord-010092-uftc8inx 12238 11 . . . cord-010092-uftc8inx 12239 1 Fifteen fifteen CD cord-010092-uftc8inx 12239 2 ( ( -LRB- cord-010092-uftc8inx 12239 3 15 15 CD cord-010092-uftc8inx 12239 4 ) ) -RRB- cord-010092-uftc8inx 12239 5 pools pool NNS cord-010092-uftc8inx 12239 6 ( ( -LRB- cord-010092-uftc8inx 12239 7 181 181 CD cord-010092-uftc8inx 12239 8 samples sample NNS cord-010092-uftc8inx 12239 9 ) ) -RRB- cord-010092-uftc8inx 12239 10 gave give VBD cord-010092-uftc8inx 12239 11 RHD RHD NNP cord-010092-uftc8inx 12239 12 deletion deletion NN cord-010092-uftc8inx 12239 13 genotype genotype NN cord-010092-uftc8inx 12239 14 and and CC cord-010092-uftc8inx 12239 15 seventy seventy CD cord-010092-uftc8inx 12239 16 two two CD cord-010092-uftc8inx 12239 17 ( ( -LRB- cord-010092-uftc8inx 12239 18 72 72 CD cord-010092-uftc8inx 12239 19 ) ) -RRB- cord-010092-uftc8inx 12239 20 pools pool NNS cord-010092-uftc8inx 12239 21 ( ( -LRB- cord-010092-uftc8inx 12239 22 402 402 CD cord-010092-uftc8inx 12239 23 samples sample NNS cord-010092-uftc8inx 12239 24 ) ) -RRB- cord-010092-uftc8inx 12239 25 resulted result VBD cord-010092-uftc8inx 12239 26 to to IN cord-010092-uftc8inx 12239 27 the the DT cord-010092-uftc8inx 12239 28 presence presence NN cord-010092-uftc8inx 12239 29 of of IN cord-010092-uftc8inx 12239 30 RHD RHD NNP cord-010092-uftc8inx 12239 31 gene gene NN cord-010092-uftc8inx 12239 32 . . . cord-010092-uftc8inx 12240 1 The the DT cord-010092-uftc8inx 12240 2 72 72 CD cord-010092-uftc8inx 12240 3 positive positive JJ cord-010092-uftc8inx 12240 4 pools pool NNS cord-010092-uftc8inx 12240 5 were be VBD cord-010092-uftc8inx 12240 6 also also RB cord-010092-uftc8inx 12240 7 analyzed analyze VBN cord-010092-uftc8inx 12240 8 individually individually RB cord-010092-uftc8inx 12240 9 . . . cord-010092-uftc8inx 12241 1 The the DT cord-010092-uftc8inx 12241 2 genotype genotype NN cord-010092-uftc8inx 12241 3 results result NNS cord-010092-uftc8inx 12241 4 obtained obtain VBN cord-010092-uftc8inx 12241 5 were be VBD cord-010092-uftc8inx 12241 6 : : : cord-010092-uftc8inx 12241 7 RHD RHD NNP cord-010092-uftc8inx 12241 8 exon exon NN cord-010092-uftc8inx 12241 9 1 1 CD cord-010092-uftc8inx 12241 10 no no DT cord-010092-uftc8inx 12241 11 amplification amplification NN cord-010092-uftc8inx 12241 12 ( ( -LRB- cord-010092-uftc8inx 12241 13 1 1 CD cord-010092-uftc8inx 12241 14 ) ) -RRB- cord-010092-uftc8inx 12241 15 , , , cord-010092-uftc8inx 12241 16 RHD RHD NNP cord-010092-uftc8inx 12241 17 exon exon NN cord-010092-uftc8inx 12241 18 6 6 CD cord-010092-uftc8inx 12241 19 and and CC cord-010092-uftc8inx 12241 20 The the DT cord-010092-uftc8inx 12241 21 genotype genotype NN cord-010092-uftc8inx 12241 22 results result NNS cord-010092-uftc8inx 12241 23 obtained obtain VBN cord-010092-uftc8inx 12241 24 with with IN cord-010092-uftc8inx 12241 25 ID ID NNP cord-010092-uftc8inx 12241 26 RHD RHD NNP cord-010092-uftc8inx 12241 27 XT XT NNP cord-010092-uftc8inx 12241 28 ( ( -LRB- cord-010092-uftc8inx 12241 29 in in IN cord-010092-uftc8inx 12241 30 pools pool NNS cord-010092-uftc8inx 12241 31 and and CC cord-010092-uftc8inx 12241 32 individually individually RB cord-010092-uftc8inx 12241 33 ) ) -RRB- cord-010092-uftc8inx 12241 34 were be VBD cord-010092-uftc8inx 12241 35 concordant concordant JJ cord-010092-uftc8inx 12241 36 with with IN cord-010092-uftc8inx 12241 37 the the DT cord-010092-uftc8inx 12241 38 results result NNS cord-010092-uftc8inx 12241 39 provided provide VBN cord-010092-uftc8inx 12241 40 by by IN cord-010092-uftc8inx 12241 41 the the DT cord-010092-uftc8inx 12241 42 centers center NNS cord-010092-uftc8inx 12241 43 . . . cord-010092-uftc8inx 12242 1 Hence hence RB cord-010092-uftc8inx 12242 2 , , , cord-010092-uftc8inx 12242 3 100 100 CD cord-010092-uftc8inx 12242 4 % % NN cord-010092-uftc8inx 12242 5 accuracy accuracy NN cord-010092-uftc8inx 12242 6 was be VBD cord-010092-uftc8inx 12242 7 obtained obtain VBN cord-010092-uftc8inx 12242 8 using use VBG cord-010092-uftc8inx 12242 9 ID ID NNP cord-010092-uftc8inx 12242 10 RHD RHD NNP cord-010092-uftc8inx 12242 11 XT XT NNP cord-010092-uftc8inx 12242 12 with with IN cord-010092-uftc8inx 12242 13 DNA dna NN cord-010092-uftc8inx 12242 14 pooled pool VBN cord-010092-uftc8inx 12242 15 samples sample NNS cord-010092-uftc8inx 12242 16 . . . cord-010092-uftc8inx 12243 1 The the DT cord-010092-uftc8inx 12243 2 results result NNS cord-010092-uftc8inx 12243 3 of of IN cord-010092-uftc8inx 12243 4 Rh Rh NNP cord-010092-uftc8inx 12243 5 NGS NGS NNP cord-010092-uftc8inx 12243 6 for for IN cord-010092-uftc8inx 12243 7 the the DT cord-010092-uftc8inx 12243 8 samples sample NNS cord-010092-uftc8inx 12243 9 with with IN cord-010092-uftc8inx 12243 10 inconclusive inconclusive JJ cord-010092-uftc8inx 12243 11 results result NNS cord-010092-uftc8inx 12243 12 by by IN cord-010092-uftc8inx 12243 13 ID ID NNP cord-010092-uftc8inx 12243 14 RHD RHD NNP cord-010092-uftc8inx 12243 15 XT XT NNP cord-010092-uftc8inx 12243 16 showed show VBD cord-010092-uftc8inx 12243 17 RHD RHD NNP cord-010092-uftc8inx 12243 18 variants variant NNS cord-010092-uftc8inx 12243 19 previously previously RB cord-010092-uftc8inx 12243 20 described describe VBD cord-010092-uftc8inx 12243 21 : : : cord-010092-uftc8inx 12243 22 1 1 CD cord-010092-uftc8inx 12243 23 sample sample NN cord-010092-uftc8inx 12244 1 RHD*93 rhd*93 UH cord-010092-uftc8inx 12244 2 - - HYPH cord-010092-uftc8inx 12244 3 94insT 94inst CD cord-010092-uftc8inx 12245 1 ( ( -LRB- cord-010092-uftc8inx 12245 2 DEL DEL NNP cord-010092-uftc8inx 12245 3 ) ) -RRB- cord-010092-uftc8inx 12245 4 , , , cord-010092-uftc8inx 12245 5 1 1 CD cord-010092-uftc8inx 12245 6 sample sample NN cord-010092-uftc8inx 12245 7 RHD*IVS3 rhd*ivs3 NN cord-010092-uftc8inx 12245 8 + + SYM cord-010092-uftc8inx 12245 9 1 1 CD cord-010092-uftc8inx 12245 10 G g NN cord-010092-uftc8inx 12245 11 ( ( -LRB- cord-010092-uftc8inx 12245 12 DEL DEL NNP cord-010092-uftc8inx 12245 13 ) ) -RRB- cord-010092-uftc8inx 12245 14 , , , cord-010092-uftc8inx 12245 15 9 9 CD cord-010092-uftc8inx 12245 16 samples sample NNS cord-010092-uftc8inx 12245 17 RHD*weak RHD*weak NNP cord-010092-uftc8inx 12245 18 D d NN cord-010092-uftc8inx 12245 19 type type NN cord-010092-uftc8inx 12245 20 11 11 CD cord-010092-uftc8inx 12245 21 ( ( -LRB- cord-010092-uftc8inx 12245 22 Partial Partial NNP cord-010092-uftc8inx 12245 23 D D NNP cord-010092-uftc8inx 12245 24 ) ) -RRB- cord-010092-uftc8inx 12245 25 , , , cord-010092-uftc8inx 12245 26 1 1 CD cord-010092-uftc8inx 12245 27 sample sample NN cord-010092-uftc8inx 12245 28 RHD*weak RHD*weak NNP cord-010092-uftc8inx 12245 29 D D NNP cord-010092-uftc8inx 12245 30 type type NN cord-010092-uftc8inx 12245 31 5 5 CD cord-010092-uftc8inx 12246 1 ( ( -LRB- cord-010092-uftc8inx 12246 2 Weak Weak NNP cord-010092-uftc8inx 12246 3 D D NNP cord-010092-uftc8inx 12246 4 ) ) -RRB- cord-010092-uftc8inx 12246 5 , , , cord-010092-uftc8inx 12246 6 1 1 CD cord-010092-uftc8inx 12246 7 sample sample NN cord-010092-uftc8inx 12246 8 RHD*weak RHD*weak NNP cord-010092-uftc8inx 12246 9 D D NNP cord-010092-uftc8inx 12246 10 type type NN cord-010092-uftc8inx 12246 11 61 61 CD cord-010092-uftc8inx 12247 1 ( ( -LRB- cord-010092-uftc8inx 12247 2 Weak Weak NNP cord-010092-uftc8inx 12247 3 D d NN cord-010092-uftc8inx 12247 4 ) ) -RRB- cord-010092-uftc8inx 12247 5 and and CC cord-010092-uftc8inx 12247 6 not not RB cord-010092-uftc8inx 12247 7 described describe VBN cord-010092-uftc8inx 12247 8 : : : cord-010092-uftc8inx 12247 9 1 1 CD cord-010092-uftc8inx 12247 10 sample sample NN cord-010092-uftc8inx 12247 11 RHD*del rhd*del NN cord-010092-uftc8inx 12248 1 1 1 LS cord-010092-uftc8inx 12248 2 - - SYM cord-010092-uftc8inx 12248 3 5 5 CD cord-010092-uftc8inx 12249 1 ( ( -LRB- cord-010092-uftc8inx 12249 2 Unknown unknown JJ cord-010092-uftc8inx 12249 3 ) ) -RRB- cord-010092-uftc8inx 12249 4 Summary Summary NNP cord-010092-uftc8inx 12249 5 / / SYM cord-010092-uftc8inx 12249 6 Conclusions Conclusions NNPS cord-010092-uftc8inx 12249 7 : : : cord-010092-uftc8inx 12250 1 ID ID NNP cord-010092-uftc8inx 12250 2 RHD RHD NNP cord-010092-uftc8inx 12250 3 XT XT NNP cord-010092-uftc8inx 12250 4 is be VBZ cord-010092-uftc8inx 12250 5 a a DT cord-010092-uftc8inx 12250 6 high high JJ cord-010092-uftc8inx 12250 7 accurate accurate JJ cord-010092-uftc8inx 12250 8 tool tool NN cord-010092-uftc8inx 12250 9 for for IN cord-010092-uftc8inx 12250 10 genotyping genotype VBG cord-010092-uftc8inx 12250 11 the the DT cord-010092-uftc8inx 12250 12 most most RBS cord-010092-uftc8inx 12250 13 common common JJ cord-010092-uftc8inx 12250 14 RHD RHD NNP cord-010092-uftc8inx 12250 15 alleles allele NNS cord-010092-uftc8inx 12250 16 associated associate VBN cord-010092-uftc8inx 12250 17 to to IN cord-010092-uftc8inx 12250 18 weak weak JJ cord-010092-uftc8inx 12250 19 D d NN cord-010092-uftc8inx 12250 20 and and CC cord-010092-uftc8inx 12250 21 D d NN cord-010092-uftc8inx 12250 22 negative negative JJ cord-010092-uftc8inx 12250 23 phenotype phenotype NN cord-010092-uftc8inx 12250 24 in in IN cord-010092-uftc8inx 12250 25 up up IN cord-010092-uftc8inx 12250 26 to to TO cord-010092-uftc8inx 12250 27 20 20 CD cord-010092-uftc8inx 12250 28 pooled pool VBN cord-010092-uftc8inx 12250 29 DNA dna NN cord-010092-uftc8inx 12250 30 samples sample NNS cord-010092-uftc8inx 12250 31 . . . cord-010092-uftc8inx 12251 1 Use Use NNP cord-010092-uftc8inx 12251 2 of of IN cord-010092-uftc8inx 12251 3 RHD RHD NNP cord-010092-uftc8inx 12251 4 genotyping genotyping NN cord-010092-uftc8inx 12251 5 improve improve VBP cord-010092-uftc8inx 12251 6 RHD RHD NNP cord-010092-uftc8inx 12251 7 typing typing NN cord-010092-uftc8inx 12251 8 in in IN cord-010092-uftc8inx 12251 9 blood blood NN cord-010092-uftc8inx 12251 10 donations donation NNS cord-010092-uftc8inx 12252 1 Variant variant JJ cord-010092-uftc8inx 12252 2 RhD rhd NN cord-010092-uftc8inx 12252 3 alleles allele NNS cord-010092-uftc8inx 12252 4 generate generate VBP cord-010092-uftc8inx 12252 5 qualitative qualitative JJ cord-010092-uftc8inx 12252 6 / / SYM cord-010092-uftc8inx 12252 7 quantitative quantitative JJ cord-010092-uftc8inx 12252 8 alteration alteration NN cord-010092-uftc8inx 12252 9 in in IN cord-010092-uftc8inx 12252 10 serological serological JJ cord-010092-uftc8inx 12252 11 expression expression NN cord-010092-uftc8inx 12252 12 of of IN cord-010092-uftc8inx 12252 13 D d NN cord-010092-uftc8inx 12252 14 antigen antigen NN cord-010092-uftc8inx 12252 15 such such JJ cord-010092-uftc8inx 12252 16 as as IN cord-010092-uftc8inx 12252 17 weak weak JJ cord-010092-uftc8inx 12252 18 and and CC cord-010092-uftc8inx 12252 19 partial partial JJ cord-010092-uftc8inx 12252 20 RhD rhd NN cord-010092-uftc8inx 12252 21 phenotypes phenotype NNS cord-010092-uftc8inx 12252 22 which which WDT cord-010092-uftc8inx 12252 23 are be VBP cord-010092-uftc8inx 12252 24 clinically clinically RB cord-010092-uftc8inx 12252 25 important important JJ cord-010092-uftc8inx 12252 26 in in IN cord-010092-uftc8inx 12252 27 transfusion transfusion NN cord-010092-uftc8inx 12252 28 setting setting NN cord-010092-uftc8inx 12252 29 . . . cord-010092-uftc8inx 12253 1 Population population NN cord-010092-uftc8inx 12253 2 studies study NNS cord-010092-uftc8inx 12253 3 have have VBP cord-010092-uftc8inx 12253 4 shown show VBN cord-010092-uftc8inx 12253 5 varied varied JJ cord-010092-uftc8inx 12253 6 distribution distribution NN cord-010092-uftc8inx 12253 7 of of IN cord-010092-uftc8inx 12253 8 the the DT cord-010092-uftc8inx 12253 9 variant variant NN cord-010092-uftc8inx 12253 10 D d NN cord-010092-uftc8inx 12253 11 alleles allele NNS cord-010092-uftc8inx 12253 12 in in IN cord-010092-uftc8inx 12253 13 Caucasians Caucasians NNPS cord-010092-uftc8inx 12253 14 , , , cord-010092-uftc8inx 12253 15 Africans Africans NNPS cord-010092-uftc8inx 12253 16 , , , cord-010092-uftc8inx 12253 17 East East NNPS cord-010092-uftc8inx 12253 18 Asians Asians NNPS cord-010092-uftc8inx 12253 19 and and CC cord-010092-uftc8inx 12253 20 Indians Indians NNPS cord-010092-uftc8inx 12253 21 . . . cord-010092-uftc8inx 12254 1 Many many JJ cord-010092-uftc8inx 12254 2 countries country NNS cord-010092-uftc8inx 12254 3 have have VBP cord-010092-uftc8inx 12254 4 developed develop VBN cord-010092-uftc8inx 12254 5 their -PRON- PRP$ cord-010092-uftc8inx 12254 6 own own JJ cord-010092-uftc8inx 12254 7 population population NN cord-010092-uftc8inx 12254 8 - - HYPH cord-010092-uftc8inx 12254 9 specific specific JJ cord-010092-uftc8inx 12254 10 strategy strategy NN cord-010092-uftc8inx 12254 11 for for IN cord-010092-uftc8inx 12254 12 identifying identify VBG cord-010092-uftc8inx 12254 13 D d NN cord-010092-uftc8inx 12254 14 variants variant NNS cord-010092-uftc8inx 12254 15 . . . cord-010092-uftc8inx 12255 1 Our -PRON- PRP$ cord-010092-uftc8inx 12255 2 previous previous JJ cord-010092-uftc8inx 12255 3 study study NN cord-010092-uftc8inx 12255 4 in in IN cord-010092-uftc8inx 12255 5 Indian indian JJ cord-010092-uftc8inx 12255 6 population population NN cord-010092-uftc8inx 12255 7 showed show VBD cord-010092-uftc8inx 12255 8 absence absence NN cord-010092-uftc8inx 12255 9 of of IN cord-010092-uftc8inx 12255 10 weak weak JJ cord-010092-uftc8inx 12255 11 D d NN cord-010092-uftc8inx 12255 12 type type NN cord-010092-uftc8inx 12255 13 1 1 CD cord-010092-uftc8inx 12255 14 , , , cord-010092-uftc8inx 12255 15 2 2 CD cord-010092-uftc8inx 12255 16 , , , cord-010092-uftc8inx 12255 17 and and CC cord-010092-uftc8inx 12255 18 3 3 CD cord-010092-uftc8inx 12255 19 which which WDT cord-010092-uftc8inx 12255 20 are be VBP cord-010092-uftc8inx 12255 21 commonly commonly RB cord-010092-uftc8inx 12255 22 found find VBN cord-010092-uftc8inx 12255 23 in in IN cord-010092-uftc8inx 12255 24 Caucasians Caucasians NNPS cord-010092-uftc8inx 12255 25 D d NN cord-010092-uftc8inx 12255 26 variant variant NN cord-010092-uftc8inx 12255 27 individuals individual NNS cord-010092-uftc8inx 12255 28 . . . cord-010092-uftc8inx 12256 1 Instead instead RB cord-010092-uftc8inx 12256 2 , , , cord-010092-uftc8inx 12256 3 a a DT cord-010092-uftc8inx 12256 4 novel novel JJ cord-010092-uftc8inx 12256 5 population population NN cord-010092-uftc8inx 12256 6 - - HYPH cord-010092-uftc8inx 12256 7 specific specific JJ cord-010092-uftc8inx 12256 8 pattern pattern NN cord-010092-uftc8inx 12256 9 i.e.~12-kilobase i.e.~12-kilobase NNP cord-010092-uftc8inx 12256 10 duplication duplication NN cord-010092-uftc8inx 12256 11 event event NN cord-010092-uftc8inx 12256 12 , , , cord-010092-uftc8inx 12256 13 including include VBG cord-010092-uftc8inx 12256 14 exon exon NN cord-010092-uftc8inx 12256 15 3 3 CD cord-010092-uftc8inx 12256 16 , , , cord-010092-uftc8inx 12256 17 was be VBD cord-010092-uftc8inx 12256 18 predominantly predominantly RB cord-010092-uftc8inx 12256 19 identified identify VBN cord-010092-uftc8inx 12256 20 in in IN cord-010092-uftc8inx 12256 21 58.3 58.3 CD cord-010092-uftc8inx 12256 22 % % NN cord-010092-uftc8inx 12256 23 D d NN cord-010092-uftc8inx 12256 24 variant variant NN cord-010092-uftc8inx 12256 25 samples sample NNS cord-010092-uftc8inx 12256 26 . . . cord-010092-uftc8inx 12257 1 Functional functional JJ cord-010092-uftc8inx 12257 2 analyses analysis NNS cord-010092-uftc8inx 12257 3 showed show VBD cord-010092-uftc8inx 12257 4 that that IN cord-010092-uftc8inx 12257 5 this this DT cord-010092-uftc8inx 12257 6 genetic genetic JJ cord-010092-uftc8inx 12257 7 variation variation NN cord-010092-uftc8inx 12257 8 results result NNS cord-010092-uftc8inx 12257 9 in in IN cord-010092-uftc8inx 12257 10 the the DT cord-010092-uftc8inx 12257 11 expression expression NN cord-010092-uftc8inx 12257 12 of of IN cord-010092-uftc8inx 12257 13 several several JJ cord-010092-uftc8inx 12257 14 transcripts transcript NNS cord-010092-uftc8inx 12257 15 , , , cord-010092-uftc8inx 12257 16 including include VBG cord-010092-uftc8inx 12257 17 a a DT cord-010092-uftc8inx 12257 18 wild wild JJ cord-010092-uftc8inx 12257 19 - - HYPH cord-010092-uftc8inx 12257 20 type type NN cord-010092-uftc8inx 12257 21 product product NN cord-010092-uftc8inx 12257 22 . . . cord-010092-uftc8inx 12258 1 Commercial commercial JJ cord-010092-uftc8inx 12258 2 genotyping genotyping NN cord-010092-uftc8inx 12258 3 assays assay NNS cord-010092-uftc8inx 12258 4 available available JJ cord-010092-uftc8inx 12258 5 , , , cord-010092-uftc8inx 12258 6 mainly mainly RB cord-010092-uftc8inx 12258 7 detect detect VBP cord-010092-uftc8inx 12258 8 common common JJ cord-010092-uftc8inx 12258 9 D d NN cord-010092-uftc8inx 12258 10 variants variant NNS cord-010092-uftc8inx 12258 11 found find VBN cord-010092-uftc8inx 12258 12 in in IN cord-010092-uftc8inx 12258 13 Caucasians Caucasians NNPS cord-010092-uftc8inx 12258 14 and and CC cord-010092-uftc8inx 12258 15 Africans Africans NNPS cord-010092-uftc8inx 12258 16 , , , cord-010092-uftc8inx 12258 17 thus thus RB cord-010092-uftc8inx 12258 18 limiting limit VBG cord-010092-uftc8inx 12258 19 its -PRON- PRP$ cord-010092-uftc8inx 12258 20 usefulness usefulness NN cord-010092-uftc8inx 12258 21 in in IN cord-010092-uftc8inx 12258 22 India India NNP cord-010092-uftc8inx 12258 23 . . . cord-010092-uftc8inx 12259 1 Hence hence RB cord-010092-uftc8inx 12259 2 , , , cord-010092-uftc8inx 12259 3 based base VBN cord-010092-uftc8inx 12259 4 on on IN cord-010092-uftc8inx 12259 5 our -PRON- PRP$ cord-010092-uftc8inx 12259 6 findings finding NNS cord-010092-uftc8inx 12259 7 we -PRON- PRP cord-010092-uftc8inx 12259 8 have have VBP cord-010092-uftc8inx 12259 9 designed design VBN cord-010092-uftc8inx 12259 10 a a DT cord-010092-uftc8inx 12259 11 multiplex multiplex JJ cord-010092-uftc8inx 12259 12 PCR pcr NN cord-010092-uftc8inx 12259 13 assay assay NN cord-010092-uftc8inx 12259 14 specific specific JJ cord-010092-uftc8inx 12259 15 for for IN cord-010092-uftc8inx 12259 16 Indian indian JJ cord-010092-uftc8inx 12259 17 population population NN cord-010092-uftc8inx 12259 18 that that WDT cord-010092-uftc8inx 12259 19 can can MD cord-010092-uftc8inx 12259 20 be be VB cord-010092-uftc8inx 12259 21 easily easily RB cord-010092-uftc8inx 12259 22 implemented implement VBN cord-010092-uftc8inx 12259 23 at at IN cord-010092-uftc8inx 12259 24 the the DT cord-010092-uftc8inx 12259 25 laboratory laboratory NN cord-010092-uftc8inx 12259 26 level level NN cord-010092-uftc8inx 12259 27 for for IN cord-010092-uftc8inx 12259 28 genotyping genotype VBG cord-010092-uftc8inx 12259 29 variant variant NN cord-010092-uftc8inx 12259 30 RHD RHD NNP cord-010092-uftc8inx 12259 31 . . . cord-010092-uftc8inx 12260 1 Aims aim VBZ cord-010092-uftc8inx 12260 2 : : : cord-010092-uftc8inx 12261 1 To to TO cord-010092-uftc8inx 12261 2 characterize characterize VB cord-010092-uftc8inx 12261 3 RhD rhd NN cord-010092-uftc8inx 12261 4 variants variant NNS cord-010092-uftc8inx 12261 5 using use VBG cord-010092-uftc8inx 12261 6 " " `` cord-010092-uftc8inx 12261 7 Indian indian JJ cord-010092-uftc8inx 12261 8 - - HYPH cord-010092-uftc8inx 12261 9 specific specific JJ cord-010092-uftc8inx 12261 10 , , , cord-010092-uftc8inx 12261 11 RHD RHD NNP cord-010092-uftc8inx 12261 12 genotyping genotyping NN cord-010092-uftc8inx 12261 13 assay assay NN cord-010092-uftc8inx 12261 14 " " '' cord-010092-uftc8inx 12261 15 . . . cord-010092-uftc8inx 12262 1 Methods method NNS cord-010092-uftc8inx 12262 2 : : : cord-010092-uftc8inx 12263 1 Seventy seventy CD cord-010092-uftc8inx 12263 2 samples sample NNS cord-010092-uftc8inx 12263 3 referred refer VBN cord-010092-uftc8inx 12263 4 to to IN cord-010092-uftc8inx 12263 5 our -PRON- PRP$ cord-010092-uftc8inx 12263 6 laboratory laboratory NN cord-010092-uftc8inx 12263 7 for for IN cord-010092-uftc8inx 12263 8 molecular molecular JJ cord-010092-uftc8inx 12263 9 characterization characterization NN cord-010092-uftc8inx 12263 10 of of IN cord-010092-uftc8inx 12263 11 RhD rhd NN cord-010092-uftc8inx 12263 12 variants variant NNS cord-010092-uftc8inx 12263 13 were be VBD cord-010092-uftc8inx 12263 14 included include VBN cord-010092-uftc8inx 12263 15 in in IN cord-010092-uftc8inx 12263 16 this this DT cord-010092-uftc8inx 12263 17 study study NN cord-010092-uftc8inx 12263 18 . . . cord-010092-uftc8inx 12264 1 All all DT cord-010092-uftc8inx 12264 2 RhD rhd NN cord-010092-uftc8inx 12264 3 variant variant NN cord-010092-uftc8inx 12264 4 samples sample NNS cord-010092-uftc8inx 12264 5 were be VBD cord-010092-uftc8inx 12264 6 serologically serologically RB cord-010092-uftc8inx 12264 7 typed type VBN cord-010092-uftc8inx 12264 8 for for IN cord-010092-uftc8inx 12264 9 Results result NNS cord-010092-uftc8inx 12264 10 : : : cord-010092-uftc8inx 12265 1 Out out IN cord-010092-uftc8inx 12265 2 of of IN cord-010092-uftc8inx 12265 3 the the DT cord-010092-uftc8inx 12265 4 70 70 CD cord-010092-uftc8inx 12265 5 RhD rhd NN cord-010092-uftc8inx 12265 6 variants variant NNS cord-010092-uftc8inx 12265 7 included include VBN cord-010092-uftc8inx 12265 8 in in IN cord-010092-uftc8inx 12265 9 this this DT cord-010092-uftc8inx 12265 10 study study NN cord-010092-uftc8inx 12265 11 , , , cord-010092-uftc8inx 12265 12 49 49 CD cord-010092-uftc8inx 12265 13 samples sample NNS cord-010092-uftc8inx 12265 14 ( ( -LRB- cord-010092-uftc8inx 12265 15 70 70 CD cord-010092-uftc8inx 12265 16 % % NN cord-010092-uftc8inx 12265 17 ) ) -RRB- cord-010092-uftc8inx 12265 18 showed show VBD cord-010092-uftc8inx 12265 19 presence presence NN cord-010092-uftc8inx 12265 20 of of IN cord-010092-uftc8inx 12265 21 Indian indian JJ cord-010092-uftc8inx 12265 22 specific specific JJ cord-010092-uftc8inx 12265 23 allele allele NN cord-010092-uftc8inx 12265 24 i.e. i.e. FW cord-010092-uftc8inx 12265 25 exon exon NN cord-010092-uftc8inx 12265 26 3 3 CD cord-010092-uftc8inx 12265 27 duplication duplication NN cord-010092-uftc8inx 12265 28 . . . cord-010092-uftc8inx 12266 1 Seventeen seventeen CD cord-010092-uftc8inx 12266 2 RhD rhd NN cord-010092-uftc8inx 12266 3 variants variant NNS cord-010092-uftc8inx 12266 4 samples sample NNS cord-010092-uftc8inx 12266 5 showed show VBD cord-010092-uftc8inx 12266 6 presence presence NN cord-010092-uftc8inx 12266 7 of of IN cord-010092-uftc8inx 12266 8 both both DT cord-010092-uftc8inx 12266 9 exon exon NN cord-010092-uftc8inx 12266 10 5 5 CD cord-010092-uftc8inx 12266 11 and and CC cord-010092-uftc8inx 12266 12 10 10 CD cord-010092-uftc8inx 12266 13 . . . cord-010092-uftc8inx 12267 1 QMPSF QMPSF NNP cord-010092-uftc8inx 12267 2 analysis analysis NN cord-010092-uftc8inx 12267 3 of of IN cord-010092-uftc8inx 12267 4 these these DT cord-010092-uftc8inx 12267 5 samples sample NNS cord-010092-uftc8inx 12267 6 excluded exclude VBN cord-010092-uftc8inx 12267 7 involvement involvement NN cord-010092-uftc8inx 12267 8 of of IN cord-010092-uftc8inx 12267 9 RHD RHD NNP cord-010092-uftc8inx 12267 10 - - HYPH cord-010092-uftc8inx 12267 11 RHCE RHCE NNP cord-010092-uftc8inx 12267 12 - - HYPH cord-010092-uftc8inx 12267 13 RHD RHD NNP cord-010092-uftc8inx 12267 14 hybrids hybrid NNS cord-010092-uftc8inx 12267 15 . . . cord-010092-uftc8inx 12268 1 Sixty sixty CD cord-010092-uftc8inx 12268 2 of of IN cord-010092-uftc8inx 12268 3 the the DT cord-010092-uftc8inx 12268 4 seventy seventy CD cord-010092-uftc8inx 12268 5 D d NN cord-010092-uftc8inx 12268 6 variant variant NN cord-010092-uftc8inx 12268 7 individual individual NN cord-010092-uftc8inx 12268 8 had have VBD cord-010092-uftc8inx 12268 9 R r NN cord-010092-uftc8inx 12268 10 1 1 CD cord-010092-uftc8inx 12268 11 r r NN cord-010092-uftc8inx 12268 12 genotype genotype NN cord-010092-uftc8inx 12269 1 This this DT cord-010092-uftc8inx 12269 2 assay assay NN cord-010092-uftc8inx 12269 3 thus thus RB cord-010092-uftc8inx 12269 4 can can MD cord-010092-uftc8inx 12269 5 be be VB cord-010092-uftc8inx 12269 6 used use VBN cord-010092-uftc8inx 12269 7 routinely routinely RB cord-010092-uftc8inx 12269 8 in in IN cord-010092-uftc8inx 12269 9 Indian indian JJ cord-010092-uftc8inx 12269 10 laboratories laboratory NNS cord-010092-uftc8inx 12269 11 to to TO cord-010092-uftc8inx 12269 12 identify identify VB cord-010092-uftc8inx 12269 13 and and CC cord-010092-uftc8inx 12269 14 characterize characterize VB cord-010092-uftc8inx 12269 15 RhD rhd NN cord-010092-uftc8inx 12269 16 variants variant NNS cord-010092-uftc8inx 12269 17 . . . cord-010092-uftc8inx 12270 1 -128 -128 NNP cord-010092-uftc8inx 12270 2 non non JJ cord-010092-uftc8inx 12270 3 - - JJ cord-010092-uftc8inx 12270 4 invasive invasive JJ cord-010092-uftc8inx 12270 5 fetal fetal JJ cord-010092-uftc8inx 12270 6 KEL1 kel1 JJ cord-010092-uftc8inx 12270 7 genotypes genotype NNS cord-010092-uftc8inx 12270 8 from from IN cord-010092-uftc8inx 12270 9 allo allo NN cord-010092-uftc8inx 12270 10 - - HYPH cord-010092-uftc8inx 12270 11 immunized immunize VBN cord-010092-uftc8inx 12270 12 anti anti JJ cord-010092-uftc8inx 12270 13 - - JJ cord-010092-uftc8inx 12270 14 KEL1 kel1 JJ cord-010092-uftc8inx 12270 15 women woman NNS cord-010092-uftc8inx 12270 16 were be VBD cord-010092-uftc8inx 12270 17 done do VBN cord-010092-uftc8inx 12270 18 ( ( -LRB- cord-010092-uftc8inx 12270 19 34 34 CD cord-010092-uftc8inx 12270 20 positive positive JJ cord-010092-uftc8inx 12270 21 confirmed confirm VBN cord-010092-uftc8inx 12270 22 fetuses fetus NNS cord-010092-uftc8inx 12270 23 , , , cord-010092-uftc8inx 12270 24 6 6 CD cord-010092-uftc8inx 12270 25 undetermined undetermined JJ cord-010092-uftc8inx 12270 26 , , , cord-010092-uftc8inx 12270 27 16 16 CD cord-010092-uftc8inx 12270 28 positive positive JJ cord-010092-uftc8inx 12270 29 non non NNS cord-010092-uftc8inx 12270 30 - - JJ cord-010092-uftc8inx 12270 31 confirmed confirm VBN cord-010092-uftc8inx 12270 32 , , , cord-010092-uftc8inx 12270 33 22 22 CD cord-010092-uftc8inx 12270 34 negative negative JJ cord-010092-uftc8inx 12270 35 non non JJ cord-010092-uftc8inx 12270 36 - - JJ cord-010092-uftc8inx 12270 37 confirmed confirmed JJ cord-010092-uftc8inx 12270 38 and and CC cord-010092-uftc8inx 12270 39 50 50 CD cord-010092-uftc8inx 12270 40 negative negative JJ cord-010092-uftc8inx 12270 41 confirmed confirm VBN cord-010092-uftc8inx 12270 42 ) ) -RRB- cord-010092-uftc8inx 12270 43 . . . cord-010092-uftc8inx 12271 1 -190 -190 IN cord-010092-uftc8inx 12271 2 non non JJ cord-010092-uftc8inx 12271 3 - - JJ cord-010092-uftc8inx 12271 4 invasive invasive JJ cord-010092-uftc8inx 12271 5 fetal fetal JJ cord-010092-uftc8inx 12271 6 RHc RHc NNS cord-010092-uftc8inx 12271 7 genotypes genotype NNS cord-010092-uftc8inx 12271 8 from from IN cord-010092-uftc8inx 12271 9 allo allo NN cord-010092-uftc8inx 12271 10 - - HYPH cord-010092-uftc8inx 12271 11 immunized immunize VBN cord-010092-uftc8inx 12271 12 anti anti JJ cord-010092-uftc8inx 12271 13 - - JJ cord-010092-uftc8inx 12271 14 RH4 rh4 JJ cord-010092-uftc8inx 12271 15 women woman NNS cord-010092-uftc8inx 12271 16 were be VBD cord-010092-uftc8inx 12271 17 done do VBN cord-010092-uftc8inx 12271 18 non non JJ cord-010092-uftc8inx 12271 19 - - JJ cord-010092-uftc8inx 12271 20 invasive invasive JJ cord-010092-uftc8inx 12271 21 fetal fetal JJ cord-010092-uftc8inx 12271 22 RHE rhe JJ cord-010092-uftc8inx 12271 23 genotypes genotype NNS cord-010092-uftc8inx 12271 24 from from IN cord-010092-uftc8inx 12271 25 allo allo NN cord-010092-uftc8inx 12271 26 - - HYPH cord-010092-uftc8inx 12271 27 immunized immunize VBN cord-010092-uftc8inx 12271 28 anti anti JJ cord-010092-uftc8inx 12271 29 - - JJ cord-010092-uftc8inx 12271 30 RH3 rh3 JJ cord-010092-uftc8inx 12271 31 women woman NNS cord-010092-uftc8inx 12271 32 were be VBD cord-010092-uftc8inx 12271 33 done do VBN cord-010092-uftc8inx 12271 34 ( ( -LRB- cord-010092-uftc8inx 12271 35 66 66 CD cord-010092-uftc8inx 12271 36 positive positive JJ cord-010092-uftc8inx 12271 37 foetuses foetus NNS cord-010092-uftc8inx 12271 38 , , , cord-010092-uftc8inx 12271 39 1 1 CD cord-010092-uftc8inx 12271 40 undetermined undetermined JJ cord-010092-uftc8inx 12271 41 For for IN cord-010092-uftc8inx 12271 42 21,5 21,5 CD cord-010092-uftc8inx 12271 43 % % NN cord-010092-uftc8inx 12271 44 of of IN cord-010092-uftc8inx 12271 45 the the DT cord-010092-uftc8inx 12271 46 allo allo NN cord-010092-uftc8inx 12271 47 - - HYPH cord-010092-uftc8inx 12271 48 immunized immunize VBN cord-010092-uftc8inx 12271 49 women woman NNS cord-010092-uftc8inx 12271 50 , , , cord-010092-uftc8inx 12271 51 the the DT cord-010092-uftc8inx 12271 52 pregnancy pregnancy NN cord-010092-uftc8inx 12271 53 was be VBD cord-010092-uftc8inx 12271 54 compatible compatible JJ cord-010092-uftc8inx 12271 55 and and CC cord-010092-uftc8inx 12271 56 no no DT cord-010092-uftc8inx 12271 57 specific specific JJ cord-010092-uftc8inx 12271 58 antenatal antenatal JJ cord-010092-uftc8inx 12271 59 monitoring monitoring NN cord-010092-uftc8inx 12271 60 was be VBD cord-010092-uftc8inx 12271 61 necessary necessary JJ cord-010092-uftc8inx 12272 1 Summary Summary NNP cord-010092-uftc8inx 12272 2 / / SYM cord-010092-uftc8inx 12272 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 12272 4 : : : cord-010092-uftc8inx 12273 1 Non non JJ cord-010092-uftc8inx 12273 2 - - JJ cord-010092-uftc8inx 12273 3 invasive invasive JJ cord-010092-uftc8inx 12273 4 fetal fetal JJ cord-010092-uftc8inx 12273 5 red red JJ cord-010092-uftc8inx 12273 6 blood blood NN cord-010092-uftc8inx 12273 7 cell cell NN cord-010092-uftc8inx 12273 8 genotype genotype NN cord-010092-uftc8inx 12273 9 is be VBZ cord-010092-uftc8inx 12273 10 a a DT cord-010092-uftc8inx 12273 11 powerful powerful JJ cord-010092-uftc8inx 12273 12 tool tool NN cord-010092-uftc8inx 12273 13 to to TO cord-010092-uftc8inx 12273 14 diagnose diagnose VB cord-010092-uftc8inx 12273 15 a a DT cord-010092-uftc8inx 12273 16 feto feto JJ cord-010092-uftc8inx 12273 17 - - HYPH cord-010092-uftc8inx 12273 18 maternal maternal JJ cord-010092-uftc8inx 12273 19 red red JJ cord-010092-uftc8inx 12273 20 blood blood NN cord-010092-uftc8inx 12273 21 cells cell NNS cord-010092-uftc8inx 12273 22 incompatibility incompatibility NN cord-010092-uftc8inx 12273 23 and and CC cord-010092-uftc8inx 12273 24 allows allow VBZ cord-010092-uftc8inx 12273 25 to to TO cord-010092-uftc8inx 12273 26 legitimize legitimize VB cord-010092-uftc8inx 12273 27 a a DT cord-010092-uftc8inx 12273 28 costly costly JJ cord-010092-uftc8inx 12273 29 and and CC cord-010092-uftc8inx 12273 30 heavy heavy JJ cord-010092-uftc8inx 12273 31 specific specific JJ cord-010092-uftc8inx 12273 32 antenatal antenatal JJ cord-010092-uftc8inx 12273 33 monitoring monitoring NN cord-010092-uftc8inx 12273 34 S S NNP cord-010092-uftc8inx 12273 35 Purchla Purchla NNP cord-010092-uftc8inx 12273 36 - - HYPH cord-010092-uftc8inx 12273 37 Szepioła Szepioła NNP cord-010092-uftc8inx 12273 38 1 1 CD cord-010092-uftc8inx 12273 39 , , , cord-010092-uftc8inx 12273 40 M M NNP cord-010092-uftc8inx 12273 41 Krzemienowska Krzemienowska NNP cord-010092-uftc8inx 12273 42 2 2 CD cord-010092-uftc8inx 12273 43 , , , cord-010092-uftc8inx 12273 44 M M NNP cord-010092-uftc8inx 12273 45 Pelc Pelc NNP cord-010092-uftc8inx 12273 46 - - HYPH cord-010092-uftc8inx 12273 47 Kłopotowska Kłopotowska NNP cord-010092-uftc8inx 12273 48 2 2 CD cord-010092-uftc8inx 12273 49 , , , cord-010092-uftc8inx 12273 50 M M NNP cord-010092-uftc8inx 12273 51 Jurkowska Jurkowska NNP cord-010092-uftc8inx 12273 52 3 3 CD cord-010092-uftc8inx 12273 53 , , , cord-010092-uftc8inx 12273 54 M M NNP cord-010092-uftc8inx 12273 55 Debska Debska NNP cord-010092-uftc8inx 12273 56 4 4 CD cord-010092-uftc8inx 12273 57 , , , cord-010092-uftc8inx 12273 58 M M NNP cord-010092-uftc8inx 12273 59 Uhrynowska Uhrynowska NNP cord-010092-uftc8inx 12273 60 2 2 CD cord-010092-uftc8inx 12273 61 and and CC cord-010092-uftc8inx 12273 62 E E NNP cord-010092-uftc8inx 12273 63 Brojer Brojer NNP cord-010092-uftc8inx 12274 1 The the DT cord-010092-uftc8inx 12274 2 test test NN cord-010092-uftc8inx 12274 3 developed develop VBN cord-010092-uftc8inx 12274 4 by by IN cord-010092-uftc8inx 12274 5 IHTM IHTM NNP cord-010092-uftc8inx 12274 6 has have VBZ cord-010092-uftc8inx 12274 7 been be VBN cord-010092-uftc8inx 12274 8 offered offer VBN cord-010092-uftc8inx 12274 9 to to IN cord-010092-uftc8inx 12274 10 clinicians clinician NNS cord-010092-uftc8inx 12274 11 and and CC cord-010092-uftc8inx 12274 12 pregnant pregnant JJ cord-010092-uftc8inx 12274 13 women woman NNS cord-010092-uftc8inx 12274 14 since since IN cord-010092-uftc8inx 12274 15 2016 2016 CD cord-010092-uftc8inx 12274 16 but but CC cord-010092-uftc8inx 12274 17 it -PRON- PRP cord-010092-uftc8inx 12274 18 is be VBZ cord-010092-uftc8inx 12274 19 not not RB cord-010092-uftc8inx 12274 20 covered cover VBN cord-010092-uftc8inx 12274 21 by by IN cord-010092-uftc8inx 12274 22 the the DT cord-010092-uftc8inx 12274 23 health health NN cord-010092-uftc8inx 12274 24 care care NN cord-010092-uftc8inx 12274 25 system system NN cord-010092-uftc8inx 12274 26 . . . cord-010092-uftc8inx 12275 1 RHD RHD NNP cord-010092-uftc8inx 12275 2 NIPT NIPT NNP cord-010092-uftc8inx 12275 3 is be VBZ cord-010092-uftc8inx 12275 4 not not RB cord-010092-uftc8inx 12275 5 informative informative JJ cord-010092-uftc8inx 12275 6 for for IN cord-010092-uftc8inx 12275 7 mothers mother NNS cord-010092-uftc8inx 12275 8 with with IN cord-010092-uftc8inx 12275 9 RHD RHD NNP cord-010092-uftc8inx 12275 10 variant variant NN cord-010092-uftc8inx 12275 11 . . . cord-010092-uftc8inx 12276 1 In in IN cord-010092-uftc8inx 12276 2 such such JJ cord-010092-uftc8inx 12276 3 cases case NNS cord-010092-uftc8inx 12276 4 further further JJ cord-010092-uftc8inx 12276 5 analysis analysis NN cord-010092-uftc8inx 12276 6 of of IN cord-010092-uftc8inx 12276 7 the the DT cord-010092-uftc8inx 12276 8 molecular molecular JJ cord-010092-uftc8inx 12276 9 background background NN cord-010092-uftc8inx 12276 10 is be VBZ cord-010092-uftc8inx 12276 11 offered offer VBN cord-010092-uftc8inx 12276 12 to to TO cord-010092-uftc8inx 12276 13 exclude exclude VB cord-010092-uftc8inx 12276 14 from from IN cord-010092-uftc8inx 12276 15 immunoprophylaxis immunoprophylaxis NNP cord-010092-uftc8inx 12276 16 the the DT cord-010092-uftc8inx 12276 17 women woman NNS cord-010092-uftc8inx 12276 18 with with IN cord-010092-uftc8inx 12276 19 weak weak JJ cord-010092-uftc8inx 12276 20 RhD rhd NN cord-010092-uftc8inx 12276 21 type type NN cord-010092-uftc8inx 12276 22 1 1 CD cord-010092-uftc8inx 12276 23 , , , cord-010092-uftc8inx 12276 24 2 2 CD cord-010092-uftc8inx 12276 25 and and CC cord-010092-uftc8inx 12276 26 3 3 CD cord-010092-uftc8inx 12276 27 . . . cord-010092-uftc8inx 12277 1 Aims aim VBZ cord-010092-uftc8inx 12277 2 : : : cord-010092-uftc8inx 12277 3 Summary summary NN cord-010092-uftc8inx 12277 4 of of IN cord-010092-uftc8inx 12277 5 a a DT cord-010092-uftc8inx 12277 6 3-year 3-year CD cord-010092-uftc8inx 12277 7 period period NN cord-010092-uftc8inx 12277 8 of of IN cord-010092-uftc8inx 12277 9 routine routine JJ cord-010092-uftc8inx 12277 10 RHD RHD NNP cord-010092-uftc8inx 12277 11 NIPT NIPT NNP cord-010092-uftc8inx 12277 12 available available JJ cord-010092-uftc8inx 12277 13 at at IN cord-010092-uftc8inx 12277 14 IHTM IHTM NNP cord-010092-uftc8inx 12277 15 . . . cord-010092-uftc8inx 12278 1 Methods method NNS cord-010092-uftc8inx 12278 2 : : : cord-010092-uftc8inx 12278 3 cffDNA cffDNA NNP cord-010092-uftc8inx 12278 4 isolated isolate VBN cord-010092-uftc8inx 12278 5 using use VBG cord-010092-uftc8inx 12278 6 easyMag easyMag NNP cord-010092-uftc8inx 12278 7 , , , cord-010092-uftc8inx 12278 8 Biomerieux Biomerieux NNP cord-010092-uftc8inx 12278 9 from from IN cord-010092-uftc8inx 12278 10 plasma plasma NN cord-010092-uftc8inx 12278 11 of of IN cord-010092-uftc8inx 12278 12 366 366 CD cord-010092-uftc8inx 12278 13 pregnant pregnant JJ cord-010092-uftc8inx 12278 14 women woman NNS cord-010092-uftc8inx 12278 15 determined determine VBN cord-010092-uftc8inx 12278 16 with with IN cord-010092-uftc8inx 12278 17 standard standard JJ cord-010092-uftc8inx 12278 18 serology serology NN cord-010092-uftc8inx 12278 19 as as IN cord-010092-uftc8inx 12278 20 RhD rhd NN cord-010092-uftc8inx 12278 21 - - HYPH cord-010092-uftc8inx 12278 22 negative negative JJ cord-010092-uftc8inx 12278 23 ( ( -LRB- cord-010092-uftc8inx 12278 24 in in IN cord-010092-uftc8inx 12278 25 8 8 CD cord-010092-uftc8inx 12278 26 - - SYM cord-010092-uftc8inx 12278 27 38 38 CD cord-010092-uftc8inx 12278 28 week week NN cord-010092-uftc8inx 12278 29 of of IN cord-010092-uftc8inx 12278 30 gestation gestation NN cord-010092-uftc8inx 12278 31 ) ) -RRB- cord-010092-uftc8inx 12278 32 was be VBD cord-010092-uftc8inx 12278 33 examined examine VBN cord-010092-uftc8inx 12278 34 for for IN cord-010092-uftc8inx 12278 35 the the DT cord-010092-uftc8inx 12278 36 presence presence NN cord-010092-uftc8inx 12278 37 of of IN cord-010092-uftc8inx 12278 38 exons exon NNS cord-010092-uftc8inx 12278 39 5 5 CD cord-010092-uftc8inx 12278 40 and and CC cord-010092-uftc8inx 12278 41 7 7 CD cord-010092-uftc8inx 12278 42 of of IN cord-010092-uftc8inx 12278 43 RHD RHD NNP cord-010092-uftc8inx 12278 44 and and CC cord-010092-uftc8inx 12278 45 CCR5 CCR5 NNP cord-010092-uftc8inx 12278 46 by by IN cord-010092-uftc8inx 12278 47 realtime realtime NNP cord-010092-uftc8inx 12278 48 PCR PCR NNP cord-010092-uftc8inx 12278 49 using use VBG cord-010092-uftc8inx 12278 50 LC480II LC480II NNP cord-010092-uftc8inx 12278 51 ( ( -LRB- cord-010092-uftc8inx 12278 52 Roche Roche NNP cord-010092-uftc8inx 12278 53 ) ) -RRB- cord-010092-uftc8inx 12278 54 . . . cord-010092-uftc8inx 12279 1 Maternal maternal JJ cord-010092-uftc8inx 12279 2 DNA DNA NNP cord-010092-uftc8inx 12279 3 from from IN cord-010092-uftc8inx 12279 4 whole whole JJ cord-010092-uftc8inx 12279 5 blood blood NN cord-010092-uftc8inx 12279 6 was be VBD cord-010092-uftc8inx 12279 7 tested test VBN cord-010092-uftc8inx 12279 8 for for IN cord-010092-uftc8inx 12279 9 identification identification NN cord-010092-uftc8inx 12279 10 of of IN cord-010092-uftc8inx 12279 11 RHD RHD NNP cord-010092-uftc8inx 12279 12 variant variant NN cord-010092-uftc8inx 12279 13 using use VBG cord-010092-uftc8inx 12279 14 RBC RBC NNP cord-010092-uftc8inx 12279 15 FluoGene FluoGene NNP cord-010092-uftc8inx 12279 16 RBC RBC NNP cord-010092-uftc8inx 12279 17 - - HYPH cord-010092-uftc8inx 12279 18 Dweak Dweak NNP cord-010092-uftc8inx 12279 19 / / , cord-010092-uftc8inx 12279 20 variant variant NN cord-010092-uftc8inx 12279 21 ( ( -LRB- cord-010092-uftc8inx 12279 22 Inno Inno NNP cord-010092-uftc8inx 12279 23 - - HYPH cord-010092-uftc8inx 12279 24 Train Train NNP cord-010092-uftc8inx 12279 25 , , , cord-010092-uftc8inx 12279 26 Germany Germany NNP cord-010092-uftc8inx 12279 27 ) ) -RRB- cord-010092-uftc8inx 12279 28 or or CC cord-010092-uftc8inx 12279 29 the the DT cord-010092-uftc8inx 12279 30 home home NN cord-010092-uftc8inx 12279 31 - - HYPH cord-010092-uftc8inx 12279 32 made make VBN cord-010092-uftc8inx 12279 33 protocol protocol NN cord-010092-uftc8inx 12279 34 . . . cord-010092-uftc8inx 12280 1 Results result NNS cord-010092-uftc8inx 12280 2 : : : cord-010092-uftc8inx 12280 3 In in IN cord-010092-uftc8inx 12280 4 123 123 CD cord-010092-uftc8inx 12280 5 cases case NNS cord-010092-uftc8inx 12280 6 the the DT cord-010092-uftc8inx 12280 7 RHD RHD NNP cord-010092-uftc8inx 12280 8 gene gene NN cord-010092-uftc8inx 12280 9 was be VBD cord-010092-uftc8inx 12280 10 not not RB cord-010092-uftc8inx 12280 11 detected detect VBN cord-010092-uftc8inx 12280 12 in in IN cord-010092-uftc8inx 12280 13 cffDNA cffdna NN cord-010092-uftc8inx 12280 14 and and CC cord-010092-uftc8inx 12280 15 the the DT cord-010092-uftc8inx 12280 16 administration administration NN cord-010092-uftc8inx 12280 17 of of IN cord-010092-uftc8inx 12280 18 RhIg RhIg NNP cord-010092-uftc8inx 12280 19 was be VBD cord-010092-uftc8inx 12280 20 not not RB cord-010092-uftc8inx 12280 21 recommended recommend VBN cord-010092-uftc8inx 12280 22 . . . cord-010092-uftc8inx 12281 1 In in IN cord-010092-uftc8inx 12281 2 seven seven CD cord-010092-uftc8inx 12281 3 cases case NNS cord-010092-uftc8inx 12281 4 Ct Ct NNS cord-010092-uftc8inx 12281 5 - - HYPH cord-010092-uftc8inx 12281 6 values value NNS cord-010092-uftc8inx 12281 7 for for IN cord-010092-uftc8inx 12281 8 RHD RHD NNP cord-010092-uftc8inx 12281 9 and and CC cord-010092-uftc8inx 12281 10 CCR5 CCR5 NNP cord-010092-uftc8inx 12281 11 indicated indicate VBD cord-010092-uftc8inx 12281 12 a a DT cord-010092-uftc8inx 12281 13 maternal maternal JJ cord-010092-uftc8inx 12281 14 D d NN cord-010092-uftc8inx 12281 15 variant variant NN cord-010092-uftc8inx 12281 16 ( ( -LRB- cord-010092-uftc8inx 12281 17 D D NNP cord-010092-uftc8inx 12281 18 Ct Ct NNP cord-010092-uftc8inx 12281 19 CCR5-RHD CCR5-RHD NNP cord-010092-uftc8inx 12281 20 > > XX cord-010092-uftc8inx 12281 21 2 2 CD cord-010092-uftc8inx 12281 22 ) ) -RRB- cord-010092-uftc8inx 12281 23 ; ; : cord-010092-uftc8inx 12281 24 the the DT cord-010092-uftc8inx 12281 25 genetic genetic JJ cord-010092-uftc8inx 12281 26 follow follow NN cord-010092-uftc8inx 12281 27 - - HYPH cord-010092-uftc8inx 12281 28 up up NN cord-010092-uftc8inx 12281 29 of of IN cord-010092-uftc8inx 12281 30 six six CD cord-010092-uftc8inx 12281 31 of of IN cord-010092-uftc8inx 12281 32 them -PRON- PRP cord-010092-uftc8inx 12281 33 identified identify VBD cord-010092-uftc8inx 12281 34 : : : cord-010092-uftc8inx 12281 35 RHD*01W.2 RHD*01W.2 NNS cord-010092-uftc8inx 12281 36 in in IN cord-010092-uftc8inx 12281 37 4 4 CD cord-010092-uftc8inx 12281 38 cases case NNS cord-010092-uftc8inx 12281 39 , , , cord-010092-uftc8inx 12281 40 RHD*01W.1 RHD*01W.1 NNP cord-010092-uftc8inx 12281 41 and and CC cord-010092-uftc8inx 12281 42 RHD*15 RHD*15 NNS cord-010092-uftc8inx 12281 43 . . . cord-010092-uftc8inx 12282 1 In in IN cord-010092-uftc8inx 12282 2 235 235 CD cord-010092-uftc8inx 12282 3 cases case NNS cord-010092-uftc8inx 12282 4 the the DT cord-010092-uftc8inx 12282 5 RHD RHD NNP cord-010092-uftc8inx 12282 6 NIPD NIPD NNP cord-010092-uftc8inx 12282 7 results result NNS cord-010092-uftc8inx 12282 8 indicated indicate VBD cord-010092-uftc8inx 12282 9 that that IN cord-010092-uftc8inx 12282 10 a a DT cord-010092-uftc8inx 12282 11 fetus fetus NN cord-010092-uftc8inx 12282 12 is be VBZ cord-010092-uftc8inx 12282 13 RhD rhd NN cord-010092-uftc8inx 12282 14 positive positive JJ cord-010092-uftc8inx 12282 15 and and CC cord-010092-uftc8inx 12282 16 RhIg RhIg NNP cord-010092-uftc8inx 12282 17 administration administration NN cord-010092-uftc8inx 12282 18 was be VBD cord-010092-uftc8inx 12282 19 recommended recommend VBN cord-010092-uftc8inx 12282 20 It -PRON- PRP cord-010092-uftc8inx 12282 21 was be VBD cord-010092-uftc8inx 12282 22 recommended recommend VBN cord-010092-uftc8inx 12282 23 in in IN cord-010092-uftc8inx 12282 24 the the DT cord-010092-uftc8inx 12282 25 remaining remain VBG cord-010092-uftc8inx 12282 26 67 67 CD cord-010092-uftc8inx 12282 27 % % NN cord-010092-uftc8inx 12282 28 of of IN cord-010092-uftc8inx 12282 29 mothers mother NNS cord-010092-uftc8inx 12282 30 . . . cord-010092-uftc8inx 12283 1 In in IN cord-010092-uftc8inx 12283 2 1.9 1.9 CD cord-010092-uftc8inx 12283 3 % % NN cord-010092-uftc8inx 12283 4 cases case NNS cord-010092-uftc8inx 12283 5 with with IN cord-010092-uftc8inx 12283 6 maternal maternal JJ cord-010092-uftc8inx 12283 7 D d NN cord-010092-uftc8inx 12283 8 variant variant NN cord-010092-uftc8inx 12283 9 RHD RHD NNP cord-010092-uftc8inx 12283 10 NIPT NIPT NNP cord-010092-uftc8inx 12283 11 was be VBD cord-010092-uftc8inx 12283 12 not not RB cord-010092-uftc8inx 12283 13 possible possible JJ cord-010092-uftc8inx 12283 14 . . . cord-010092-uftc8inx 12284 1 However however RB cord-010092-uftc8inx 12284 2 , , , cord-010092-uftc8inx 12284 3 in in IN cord-010092-uftc8inx 12284 4 5/6 5/6 CD cord-010092-uftc8inx 12284 5 such such JJ cord-010092-uftc8inx 12284 6 cases case NNS cord-010092-uftc8inx 12284 7 the the DT cord-010092-uftc8inx 12284 8 test test NN cord-010092-uftc8inx 12284 9 is be VBZ cord-010092-uftc8inx 12284 10 unnecessary unnecessary JJ cord-010092-uftc8inx 12284 11 because because IN cord-010092-uftc8inx 12284 12 follow follow VB cord-010092-uftc8inx 12284 13 up up RP cord-010092-uftc8inx 12284 14 analysis analysis NN cord-010092-uftc8inx 12284 15 revealed reveal VBD cord-010092-uftc8inx 12284 16 maternal maternal JJ cord-010092-uftc8inx 12284 17 RHD RHD NNP cord-010092-uftc8inx 12284 18 variant variant NN cord-010092-uftc8inx 12284 19 of of IN cord-010092-uftc8inx 12284 20 the the DT cord-010092-uftc8inx 12284 21 weak weak JJ cord-010092-uftc8inx 12284 22 D D NNP cord-010092-uftc8inx 12284 23 type type NN cord-010092-uftc8inx 12284 24 1 1 CD cord-010092-uftc8inx 12284 25 and and CC cord-010092-uftc8inx 12284 26 2 2 CD cord-010092-uftc8inx 12285 1 In in IN cord-010092-uftc8inx 12285 2 Switzerland Switzerland NNP cord-010092-uftc8inx 12285 3 extended extended JJ cord-010092-uftc8inx 12285 4 antigen antigen NN cord-010092-uftc8inx 12285 5 - - HYPH cord-010092-uftc8inx 12285 6 matching matching NN cord-010092-uftc8inx 12285 7 for for IN cord-010092-uftc8inx 12285 8 Duffy Duffy NNP cord-010092-uftc8inx 12285 9 , , , cord-010092-uftc8inx 12285 10 Kidd Kidd NNP cord-010092-uftc8inx 12285 11 and and CC cord-010092-uftc8inx 12285 12 MNSbesides MNSbesides NNP cord-010092-uftc8inx 12285 13 Rhesus Rhesus NNP cord-010092-uftc8inx 12285 14 and and CC cord-010092-uftc8inx 12285 15 Kell Kell NNP cord-010092-uftc8inx 12285 16 -is -is ADD cord-010092-uftc8inx 12285 17 recommended recommend VBN cord-010092-uftc8inx 12285 18 for for IN cord-010092-uftc8inx 12285 19 sickle sickle NN cord-010092-uftc8inx 12285 20 cell cell NN cord-010092-uftc8inx 12285 21 disease disease NN cord-010092-uftc8inx 12285 22 ( ( -LRB- cord-010092-uftc8inx 12285 23 SCD SCD NNP cord-010092-uftc8inx 12285 24 ) ) -RRB- cord-010092-uftc8inx 12285 25 patients patient NNS cord-010092-uftc8inx 12285 26 . . . cord-010092-uftc8inx 12286 1 The the DT cord-010092-uftc8inx 12286 2 ethnic ethnic JJ cord-010092-uftc8inx 12286 3 diversity diversity NN cord-010092-uftc8inx 12286 4 of of IN cord-010092-uftc8inx 12286 5 red red JJ cord-010092-uftc8inx 12286 6 blood blood NN cord-010092-uftc8inx 12286 7 cell cell NN cord-010092-uftc8inx 12286 8 ( ( -LRB- cord-010092-uftc8inx 12286 9 RBC RBC NNP cord-010092-uftc8inx 12286 10 ) ) -RRB- cord-010092-uftc8inx 12286 11 antigen antigen NN cord-010092-uftc8inx 12286 12 polymorphism polymorphism NN cord-010092-uftc8inx 12286 13 engender engender VBP cord-010092-uftc8inx 12286 14 that that IN cord-010092-uftc8inx 12286 15 these these DT cord-010092-uftc8inx 12286 16 patients patient NNS cord-010092-uftc8inx 12286 17 are be VBP cord-010092-uftc8inx 12286 18 often often RB cord-010092-uftc8inx 12286 19 transfused transfuse VBN cord-010092-uftc8inx 12286 20 with with IN cord-010092-uftc8inx 12286 21 RBCs rbc NNS cord-010092-uftc8inx 12286 22 from from IN cord-010092-uftc8inx 12286 23 donors donor NNS cord-010092-uftc8inx 12286 24 of of IN cord-010092-uftc8inx 12286 25 African african JJ cord-010092-uftc8inx 12286 26 origin origin NN cord-010092-uftc8inx 12286 27 . . . cord-010092-uftc8inx 12287 1 This this DT cord-010092-uftc8inx 12287 2 strategy strategy NN cord-010092-uftc8inx 12287 3 , , , cord-010092-uftc8inx 12287 4 however however RB cord-010092-uftc8inx 12287 5 , , , cord-010092-uftc8inx 12287 6 increases increase VBZ cord-010092-uftc8inx 12287 7 the the DT cord-010092-uftc8inx 12287 8 likelihood likelihood NN cord-010092-uftc8inx 12287 9 of of IN cord-010092-uftc8inx 12287 10 being be VBG cord-010092-uftc8inx 12287 11 exposed expose VBN cord-010092-uftc8inx 12287 12 to to IN cord-010092-uftc8inx 12287 13 certain certain JJ cord-010092-uftc8inx 12287 14 low low JJ cord-010092-uftc8inx 12287 15 - - HYPH cord-010092-uftc8inx 12287 16 prevalence prevalence NN cord-010092-uftc8inx 12287 17 antigens antigen NNS cord-010092-uftc8inx 12287 18 , , , cord-010092-uftc8inx 12287 19 such such JJ cord-010092-uftc8inx 12287 20 as as IN cord-010092-uftc8inx 12287 21 Rh23 Rh23 NNP cord-010092-uftc8inx 12288 1 ( ( -LRB- cord-010092-uftc8inx 12288 2 D D NNP cord-010092-uftc8inx 12288 3 w w NNP cord-010092-uftc8inx 12288 4 ) ) -RRB- cord-010092-uftc8inx 12288 5 , , , cord-010092-uftc8inx 12288 6 as as IN cord-010092-uftc8inx 12288 7 these these DT cord-010092-uftc8inx 12288 8 are be VBP cord-010092-uftc8inx 12288 9 almost almost RB cord-010092-uftc8inx 12288 10 exclusive exclusive JJ cord-010092-uftc8inx 12288 11 to to IN cord-010092-uftc8inx 12288 12 African african JJ cord-010092-uftc8inx 12288 13 populations population NNS cord-010092-uftc8inx 12288 14 . . . cord-010092-uftc8inx 12289 1 Rh23 Rh23 NNP cord-010092-uftc8inx 12289 2 is be VBZ cord-010092-uftc8inx 12289 3 encoded encode VBN cord-010092-uftc8inx 12289 4 by by IN cord-010092-uftc8inx 12289 5 several several JJ cord-010092-uftc8inx 12289 6 types type NNS cord-010092-uftc8inx 12289 7 of of IN cord-010092-uftc8inx 12289 8 RHD*DV rhd*dv NN cord-010092-uftc8inx 12289 9 as as RB cord-010092-uftc8inx 12289 10 well well RB cord-010092-uftc8inx 12289 11 as as IN cord-010092-uftc8inx 12289 12 by by IN cord-010092-uftc8inx 12289 13 DAU-5 DAU-5 NNP cord-010092-uftc8inx 12289 14 . . . cord-010092-uftc8inx 12290 1 Anti Anti NNP cord-010092-uftc8inx 12290 2 - - NNP cord-010092-uftc8inx 12290 3 Rh23 Rh23 NNP cord-010092-uftc8inx 12290 4 is be VBZ cord-010092-uftc8inx 12290 5 associated associate VBN cord-010092-uftc8inx 12290 6 with with IN cord-010092-uftc8inx 12290 7 delayed delayed JJ cord-010092-uftc8inx 12290 8 hemolytic hemolytic JJ cord-010092-uftc8inx 12290 9 transfusion transfusion NN cord-010092-uftc8inx 12290 10 reactions reaction NNS cord-010092-uftc8inx 12290 11 ( ( -LRB- cord-010092-uftc8inx 12290 12 HTR HTR NNP cord-010092-uftc8inx 12290 13 ) ) -RRB- cord-010092-uftc8inx 12290 14 Aims aim VBZ cord-010092-uftc8inx 12290 15 : : : cord-010092-uftc8inx 12290 16 Here here RB cord-010092-uftc8inx 12290 17 we -PRON- PRP cord-010092-uftc8inx 12290 18 report report VBP cord-010092-uftc8inx 12290 19 a a DT cord-010092-uftc8inx 12290 20 specific specific JJ cord-010092-uftc8inx 12290 21 low low JJ cord-010092-uftc8inx 12290 22 - - HYPH cord-010092-uftc8inx 12290 23 prevalence prevalence NN cord-010092-uftc8inx 12290 24 antibody antibody NN cord-010092-uftc8inx 12290 25 newly newly RB cord-010092-uftc8inx 12290 26 formed form VBN cord-010092-uftc8inx 12290 27 by by IN cord-010092-uftc8inx 12290 28 the the DT cord-010092-uftc8inx 12290 29 same same JJ cord-010092-uftc8inx 12290 30 patient patient NN cord-010092-uftc8inx 12290 31 , , , cord-010092-uftc8inx 12290 32 meanwhile meanwhile RB cord-010092-uftc8inx 12290 33 gravida gravida NNP cord-010092-uftc8inx 12290 34 4 4 CD cord-010092-uftc8inx 12290 35 , , , cord-010092-uftc8inx 12290 36 para para NNP cord-010092-uftc8inx 12290 37 1 1 CD cord-010092-uftc8inx 12290 38 , , , cord-010092-uftc8inx 12290 39 causing cause VBG cord-010092-uftc8inx 12290 40 positive positive JJ cord-010092-uftc8inx 12290 41 crossmatches crossmatche NNS cord-010092-uftc8inx 12290 42 with with IN cord-010092-uftc8inx 12290 43 the the DT cord-010092-uftc8inx 12290 44 RBCs rbc NNS cord-010092-uftc8inx 12290 45 of of IN cord-010092-uftc8inx 12290 46 two two CD cord-010092-uftc8inx 12290 47 of of IN cord-010092-uftc8inx 12290 48 the the DT cord-010092-uftc8inx 12290 49 four four CD cord-010092-uftc8inx 12290 50 selected select VBN cord-010092-uftc8inx 12290 51 donors donor NNS cord-010092-uftc8inx 12290 52 . . . cord-010092-uftc8inx 12291 1 Subsequently subsequently RB cord-010092-uftc8inx 12291 2 , , , cord-010092-uftc8inx 12291 3 advanced advanced JJ cord-010092-uftc8inx 12291 4 serologic serologic NN cord-010092-uftc8inx 12291 5 and and CC cord-010092-uftc8inx 12291 6 genetic genetic JJ cord-010092-uftc8inx 12291 7 workup workup NN cord-010092-uftc8inx 12291 8 and and CC cord-010092-uftc8inx 12291 9 close close JJ cord-010092-uftc8inx 12291 10 international international JJ cord-010092-uftc8inx 12291 11 collaboration collaboration NN cord-010092-uftc8inx 12291 12 enabled enable VBD cord-010092-uftc8inx 12291 13 optimal optimal JJ cord-010092-uftc8inx 12291 14 patient patient NN cord-010092-uftc8inx 12291 15 care care NN cord-010092-uftc8inx 12291 16 . . . cord-010092-uftc8inx 12292 1 Methods method NNS cord-010092-uftc8inx 12292 2 : : : cord-010092-uftc8inx 12293 1 Standard standard JJ cord-010092-uftc8inx 12293 2 serological serological JJ cord-010092-uftc8inx 12293 3 methods method NNS cord-010092-uftc8inx 12293 4 were be VBD cord-010092-uftc8inx 12293 5 used use VBN cord-010092-uftc8inx 12293 6 for for IN cord-010092-uftc8inx 12293 7 antibody antibody NN cord-010092-uftc8inx 12293 8 specification specification NN cord-010092-uftc8inx 12293 9 ( ( -LRB- cord-010092-uftc8inx 12293 10 BioRad BioRad NNP cord-010092-uftc8inx 12293 11 , , , cord-010092-uftc8inx 12293 12 Cressier Cressier NNP cord-010092-uftc8inx 12293 13 , , , cord-010092-uftc8inx 12293 14 CH CH NNP cord-010092-uftc8inx 12293 15 and and CC cord-010092-uftc8inx 12293 16 in in IN cord-010092-uftc8inx 12293 17 - - HYPH cord-010092-uftc8inx 12293 18 house house NN cord-010092-uftc8inx 12293 19 ) ) -RRB- cord-010092-uftc8inx 12293 20 . . . cord-010092-uftc8inx 12294 1 Crossmatches crossmatche NNS cord-010092-uftc8inx 12294 2 were be VBD cord-010092-uftc8inx 12294 3 carried carry VBN cord-010092-uftc8inx 12294 4 out out RP cord-010092-uftc8inx 12294 5 by by IN cord-010092-uftc8inx 12294 6 indirect indirect JJ cord-010092-uftc8inx 12294 7 antiglobulin antiglobulin NN cord-010092-uftc8inx 12294 8 test test NN cord-010092-uftc8inx 12294 9 at at IN cord-010092-uftc8inx 12294 10 37 37 CD cord-010092-uftc8inx 12294 11 ° ° NN cord-010092-uftc8inx 12294 12 C c NN cord-010092-uftc8inx 12294 13 . . . cord-010092-uftc8inx 12295 1 Molecular molecular JJ cord-010092-uftc8inx 12295 2 typing typing NN cord-010092-uftc8inx 12295 3 of of IN cord-010092-uftc8inx 12295 4 donors donor NNS cord-010092-uftc8inx 12295 5 ' ' POS cord-010092-uftc8inx 12295 6 and and CC cord-010092-uftc8inx 12295 7 parental parental JJ cord-010092-uftc8inx 12295 8 blood blood NN cord-010092-uftc8inx 12295 9 group group NN cord-010092-uftc8inx 12295 10 antigens antigen NNS cord-010092-uftc8inx 12295 11 was be VBD cord-010092-uftc8inx 12295 12 performed perform VBN cord-010092-uftc8inx 12295 13 by by IN cord-010092-uftc8inx 12295 14 Further further JJ cord-010092-uftc8inx 12295 15 serological serological JJ cord-010092-uftc8inx 12295 16 analysis analysis NN cord-010092-uftc8inx 12295 17 ( ( -LRB- cord-010092-uftc8inx 12295 18 Institute Institute NNP cord-010092-uftc8inx 12295 19 National National NNP cord-010092-uftc8inx 12295 20 de de NNP cord-010092-uftc8inx 12295 21 Transfusion Transfusion NNP cord-010092-uftc8inx 12295 22 Sanguine Sanguine NNP cord-010092-uftc8inx 12295 23 , , , cord-010092-uftc8inx 12295 24 Paris Paris NNP cord-010092-uftc8inx 12295 25 ) ) -RRB- cord-010092-uftc8inx 12295 26 revealed reveal VBD cord-010092-uftc8inx 12295 27 an an DT cord-010092-uftc8inx 12295 28 anti anti JJ cord-010092-uftc8inx 12295 29 - - JJ cord-010092-uftc8inx 12295 30 Rh23 rh23 JJ cord-010092-uftc8inx 12296 1 in in IN cord-010092-uftc8inx 12296 2 addition addition NN cord-010092-uftc8inx 12296 3 to to IN cord-010092-uftc8inx 12296 4 anti anti JJ cord-010092-uftc8inx 12296 5 - - JJ cord-010092-uftc8inx 12296 6 Fy Fy NNP cord-010092-uftc8inx 12296 7 5 5 CD cord-010092-uftc8inx 12296 8 , , , cord-010092-uftc8inx 12296 9 anti anti JJ cord-010092-uftc8inx 12296 10 - - JJ cord-010092-uftc8inx 12296 11 E e JJ cord-010092-uftc8inx 12296 12 and and CC cord-010092-uftc8inx 12296 13 anti anti JJ cord-010092-uftc8inx 12296 14 - - NN cord-010092-uftc8inx 12296 15 Jk Jk NNP cord-010092-uftc8inx 12296 16 a a DT cord-010092-uftc8inx 12296 17 . . . cord-010092-uftc8inx 12297 1 Genotyping genotype VBG cord-010092-uftc8inx 12297 2 of of IN cord-010092-uftc8inx 12297 3 the the DT cord-010092-uftc8inx 12297 4 two two CD cord-010092-uftc8inx 12297 5 donors donor NNS cord-010092-uftc8inx 12297 6 causing cause VBG cord-010092-uftc8inx 12297 7 positive positive JJ cord-010092-uftc8inx 12297 8 crossmatches crossmatche NNS cord-010092-uftc8inx 12297 9 presented present VBD cord-010092-uftc8inx 12297 10 heterozygosity heterozygosity NN cord-010092-uftc8inx 12297 11 for for IN cord-010092-uftc8inx 12297 12 RHD*10.05 RHD*10.05 NNP cord-010092-uftc8inx 12297 13 which which WDT cord-010092-uftc8inx 12297 14 encodes encode VBZ cord-010092-uftc8inx 12297 15 Rh23 Rh23 NNP cord-010092-uftc8inx 12297 16 . . . cord-010092-uftc8inx 12298 1 The the DT cord-010092-uftc8inx 12298 2 newborn newborn NN cord-010092-uftc8inx 12298 3 's 's POS cord-010092-uftc8inx 12298 4 phenotype phenotype NN cord-010092-uftc8inx 12298 5 was be VBD cord-010092-uftc8inx 12298 6 A a DT cord-010092-uftc8inx 12298 7 R0r R0r NNP cord-010092-uftc8inx 12298 8 K- k- XX cord-010092-uftc8inx 12298 9 , , , cord-010092-uftc8inx 12298 10 Fy(a Fy(a NNP cord-010092-uftc8inx 12298 11 - - HYPH cord-010092-uftc8inx 12298 12 b+ b+ NNP cord-010092-uftc8inx 12298 13 ) ) -RRB- cord-010092-uftc8inx 12298 14 and and CC cord-010092-uftc8inx 12299 1 most most RBS cord-010092-uftc8inx 12299 2 likely likely RB cord-010092-uftc8inx 12299 3 Rh23-and Rh23-and NNP cord-010092-uftc8inx 12299 4 Jk Jk NNP cord-010092-uftc8inx 12299 5 ( ( -LRB- cord-010092-uftc8inx 12299 6 a+b+ a+b+ NNP cord-010092-uftc8inx 12299 7 ) ) -RRB- cord-010092-uftc8inx 12299 8 , , , cord-010092-uftc8inx 12299 9 considering consider VBG cord-010092-uftc8inx 12299 10 both both CC cord-010092-uftc8inx 12299 11 maternal maternal JJ cord-010092-uftc8inx 12299 12 and and CC cord-010092-uftc8inx 12299 13 paternal paternal JJ cord-010092-uftc8inx 12299 14 ( ( -LRB- cord-010092-uftc8inx 12299 15 A A NNP cord-010092-uftc8inx 12299 16 R0r r0r NN cord-010092-uftc8inx 12299 17 , , , cord-010092-uftc8inx 12299 18 K K NNP cord-010092-uftc8inx 12299 19 - - HYPH cord-010092-uftc8inx 12299 20 k+ k+ NNP cord-010092-uftc8inx 12299 21 , , , cord-010092-uftc8inx 12299 22 Fy(a Fy(a NNP cord-010092-uftc8inx 12299 23 - - HYPH cord-010092-uftc8inx 12299 24 b+ b+ NNP cord-010092-uftc8inx 12299 25 ) ) -RRB- cord-010092-uftc8inx 12299 26 , , , cord-010092-uftc8inx 12299 27 Jk(a+b- Jk(a+b- NNP cord-010092-uftc8inx 12299 28 ) ) -RRB- cord-010092-uftc8inx 12299 29 , , , cord-010092-uftc8inx 12299 30 Rh23- rh23- CD cord-010092-uftc8inx 12299 31 ) ) -RRB- cord-010092-uftc8inx 12299 32 predicted predict VBD cord-010092-uftc8inx 12299 33 phenotypes phenotype NNS cord-010092-uftc8inx 12299 34 . . . cord-010092-uftc8inx 12300 1 The the DT cord-010092-uftc8inx 12300 2 neonatal neonatal JJ cord-010092-uftc8inx 12300 3 serum serum NN cord-010092-uftc8inx 12300 4 contained contain VBD cord-010092-uftc8inx 12300 5 maternal maternal JJ cord-010092-uftc8inx 12300 6 anti anti NNP cord-010092-uftc8inx 12300 7 - - NNP cord-010092-uftc8inx 12300 8 A1 A1 NNP cord-010092-uftc8inx 12300 9 , , , cord-010092-uftc8inx 12300 10 anti anti JJ cord-010092-uftc8inx 12300 11 - - JJ cord-010092-uftc8inx 12300 12 Rh23 rh23 JJ cord-010092-uftc8inx 12300 13 and and CC cord-010092-uftc8inx 12300 14 anti anti JJ cord-010092-uftc8inx 12300 15 - - JJ cord-010092-uftc8inx 12300 16 E. e. JJ cord-010092-uftc8inx 12301 1 The the DT cord-010092-uftc8inx 12301 2 direct direct JJ cord-010092-uftc8inx 12301 3 antiglobulin antiglobulin NN cord-010092-uftc8inx 12301 4 test test NN cord-010092-uftc8inx 12301 5 was be VBD cord-010092-uftc8inx 12301 6 positive positive JJ cord-010092-uftc8inx 12301 7 but but CC cord-010092-uftc8inx 12301 8 elution elution NN cord-010092-uftc8inx 12301 9 only only RB cord-010092-uftc8inx 12301 10 showed show VBD cord-010092-uftc8inx 12301 11 nonspecific nonspecific JJ cord-010092-uftc8inx 12301 12 reactions reaction NNS cord-010092-uftc8inx 12301 13 with with IN cord-010092-uftc8inx 12301 14 papain papain NN cord-010092-uftc8inx 12301 15 - - HYPH cord-010092-uftc8inx 12301 16 treated treat VBN cord-010092-uftc8inx 12301 17 cells cell NNS cord-010092-uftc8inx 12301 18 . . . cord-010092-uftc8inx 12302 1 Latter Latter NNP cord-010092-uftc8inx 12302 2 might may MD cord-010092-uftc8inx 12302 3 have have VB cord-010092-uftc8inx 12302 4 been be VBN cord-010092-uftc8inx 12302 5 caused cause VBN cord-010092-uftc8inx 12302 6 by by IN cord-010092-uftc8inx 12302 7 anti anti JJ cord-010092-uftc8inx 12302 8 - - JJ cord-010092-uftc8inx 12302 9 Fy fy JJ cord-010092-uftc8inx 12302 10 5 5 CD cord-010092-uftc8inx 12303 1 During during IN cord-010092-uftc8inx 12303 2 her -PRON- PRP$ cord-010092-uftc8inx 12303 3 present present JJ cord-010092-uftc8inx 12303 4 pregnancy pregnancy NN cord-010092-uftc8inx 12303 5 we -PRON- PRP cord-010092-uftc8inx 12303 6 were be VBD cord-010092-uftc8inx 12303 7 able able JJ cord-010092-uftc8inx 12303 8 to to TO cord-010092-uftc8inx 12303 9 demonstrate demonstrate VB cord-010092-uftc8inx 12303 10 that that IN cord-010092-uftc8inx 12303 11 two two CD cord-010092-uftc8inx 12303 12 positive positive JJ cord-010092-uftc8inx 12303 13 crossmatches crossmatche NNS cord-010092-uftc8inx 12303 14 of of IN cord-010092-uftc8inx 12303 15 two two CD cord-010092-uftc8inx 12303 16 former former JJ cord-010092-uftc8inx 12303 17 compatible compatible JJ cord-010092-uftc8inx 12303 18 donors donor NNS cord-010092-uftc8inx 12303 19 were be VBD cord-010092-uftc8inx 12303 20 caused cause VBN cord-010092-uftc8inx 12303 21 by by IN cord-010092-uftc8inx 12303 22 a a DT cord-010092-uftc8inx 12303 23 new new JJ cord-010092-uftc8inx 12303 24 alloantibody alloantibody NN cord-010092-uftc8inx 12303 25 against against IN cord-010092-uftc8inx 12303 26 a a DT cord-010092-uftc8inx 12303 27 low low JJ cord-010092-uftc8inx 12303 28 - - HYPH cord-010092-uftc8inx 12303 29 prevalence prevalence NN cord-010092-uftc8inx 12303 30 antigen antigen NN cord-010092-uftc8inx 12303 31 , , , cord-010092-uftc8inx 12303 32 namely namely RB cord-010092-uftc8inx 12303 33 anti anti JJ cord-010092-uftc8inx 12303 34 - - NNP cord-010092-uftc8inx 12303 35 Rh23 rh23 JJ cord-010092-uftc8inx 12303 36 , , , cord-010092-uftc8inx 12303 37 derived derive VBN cord-010092-uftc8inx 12303 38 from from IN cord-010092-uftc8inx 12303 39 several several JJ cord-010092-uftc8inx 12303 40 Rh23 Rh23 NNP cord-010092-uftc8inx 12303 41 + + CC cord-010092-uftc8inx 12303 42 RBC RBC NNP cord-010092-uftc8inx 12303 43 transfusions transfusion NNS cord-010092-uftc8inx 12303 44 during during IN cord-010092-uftc8inx 12303 45 the the DT cord-010092-uftc8inx 12303 46 previous previous JJ cord-010092-uftc8inx 12303 47 pregnancy pregnancy NN cord-010092-uftc8inx 12303 48 . . . cord-010092-uftc8inx 12304 1 Despite despite IN cord-010092-uftc8inx 12304 2 this this DT cord-010092-uftc8inx 12304 3 challenging challenging JJ cord-010092-uftc8inx 12304 4 blood blood NN cord-010092-uftc8inx 12304 5 supply supply NN cord-010092-uftc8inx 12304 6 we -PRON- PRP cord-010092-uftc8inx 12304 7 were be VBD cord-010092-uftc8inx 12304 8 able able JJ cord-010092-uftc8inx 12304 9 to to TO cord-010092-uftc8inx 12304 10 support support VB cord-010092-uftc8inx 12304 11 the the DT cord-010092-uftc8inx 12304 12 patient patient NN cord-010092-uftc8inx 12304 13 with with IN cord-010092-uftc8inx 12304 14 a a DT cord-010092-uftc8inx 12304 15 total total NN cord-010092-uftc8inx 12304 16 of of IN cord-010092-uftc8inx 12304 17 ten ten CD cord-010092-uftc8inx 12304 18 antigen antigen NN cord-010092-uftc8inx 12304 19 compatible compatible JJ cord-010092-uftc8inx 12304 20 and and CC cord-010092-uftc8inx 12304 21 crossmatch crossmatch VB cord-010092-uftc8inx 12304 22 negative negative JJ cord-010092-uftc8inx 12304 23 RBC RBC NNP cord-010092-uftc8inx 12304 24 units unit NNS cord-010092-uftc8inx 12304 25 from from IN cord-010092-uftc8inx 12304 26 French french JJ cord-010092-uftc8inx 12304 27 and and CC cord-010092-uftc8inx 12304 28 Swiss swiss JJ cord-010092-uftc8inx 12304 29 donors donor NNS cord-010092-uftc8inx 12304 30 until until IN cord-010092-uftc8inx 12304 31 delivery delivery NN cord-010092-uftc8inx 12304 32 With with IN cord-010092-uftc8inx 12304 33 increasing increase VBG cord-010092-uftc8inx 12304 34 age age NN cord-010092-uftc8inx 12304 35 , , , cord-010092-uftc8inx 12304 36 the the DT cord-010092-uftc8inx 12304 37 relative relative JJ cord-010092-uftc8inx 12304 38 number number NN cord-010092-uftc8inx 12304 39 of of IN cord-010092-uftc8inx 12304 40 women woman NNS cord-010092-uftc8inx 12304 41 in in IN cord-010092-uftc8inx 12304 42 the the DT cord-010092-uftc8inx 12304 43 study study NN cord-010092-uftc8inx 12304 44 population population NN cord-010092-uftc8inx 12304 45 raise raise VBP cord-010092-uftc8inx 12304 46 from from IN cord-010092-uftc8inx 12304 47 22 22 CD cord-010092-uftc8inx 12304 48 % % NN cord-010092-uftc8inx 12304 49 in in IN cord-010092-uftc8inx 12304 50 the the DT cord-010092-uftc8inx 12304 51 patients patient NNS cord-010092-uftc8inx 12304 52 younger young JJR cord-010092-uftc8inx 12304 53 than than IN cord-010092-uftc8inx 12304 54 60 60 CD cord-010092-uftc8inx 12304 55 years year NNS cord-010092-uftc8inx 12304 56 to to IN cord-010092-uftc8inx 12304 57 58 58 CD cord-010092-uftc8inx 12304 58 % % NN cord-010092-uftc8inx 12304 59 in in IN cord-010092-uftc8inx 12304 60 the the DT cord-010092-uftc8inx 12304 61 patients patient NNS cord-010092-uftc8inx 12304 62 older old JJR cord-010092-uftc8inx 12304 63 than than IN cord-010092-uftc8inx 12304 64 80 80 CD cord-010092-uftc8inx 12304 65 years year NNS cord-010092-uftc8inx 12304 66 . . . cord-010092-uftc8inx 12305 1 Our -PRON- PRP$ cord-010092-uftc8inx 12305 2 study study NN cord-010092-uftc8inx 12305 3 showed show VBD cord-010092-uftc8inx 12305 4 that that IN cord-010092-uftc8inx 12305 5 cardiovascular cardiovascular JJ cord-010092-uftc8inx 12305 6 diseases disease NNS cord-010092-uftc8inx 12305 7 were be VBD cord-010092-uftc8inx 12305 8 the the DT cord-010092-uftc8inx 12305 9 commonest common JJS cord-010092-uftc8inx 12305 10 indications indication NNS cord-010092-uftc8inx 12305 11 for for IN cord-010092-uftc8inx 12305 12 warfarin warfarin NN cord-010092-uftc8inx 12305 13 use use NN cord-010092-uftc8inx 12305 14 in in IN cord-010092-uftc8inx 12305 15 older old JJR cord-010092-uftc8inx 12305 16 patients patient NNS cord-010092-uftc8inx 12305 17 with with IN cord-010092-uftc8inx 12305 18 59 59 CD cord-010092-uftc8inx 12305 19 % % NN cord-010092-uftc8inx 12305 20 . . . cord-010092-uftc8inx 12306 1 Only only RB cord-010092-uftc8inx 12306 2 48,5 48,5 CD cord-010092-uftc8inx 12306 3 % % NN cord-010092-uftc8inx 12306 4 achieved achieve VBD cord-010092-uftc8inx 12306 5 target target NN cord-010092-uftc8inx 12306 6 therapeutic therapeutic JJ cord-010092-uftc8inx 12306 7 range range NN cord-010092-uftc8inx 12306 8 While while IN cord-010092-uftc8inx 12306 9 the the DT cord-010092-uftc8inx 12306 10 risk risk NN cord-010092-uftc8inx 12306 11 of of IN cord-010092-uftc8inx 12306 12 thromboembolism thromboembolism NN cord-010092-uftc8inx 12306 13 and and CC cord-010092-uftc8inx 12306 14 the the DT cord-010092-uftc8inx 12306 15 subsequent subsequent JJ cord-010092-uftc8inx 12306 16 need need NN cord-010092-uftc8inx 12306 17 for for IN cord-010092-uftc8inx 12306 18 proper proper JJ cord-010092-uftc8inx 12306 19 anticoagulant anticoagulant JJ cord-010092-uftc8inx 12306 20 therapy therapy NN cord-010092-uftc8inx 12306 21 increases increase NNS cord-010092-uftc8inx 12306 22 sharply sharply RB cord-010092-uftc8inx 12306 23 with with IN cord-010092-uftc8inx 12306 24 age age NN cord-010092-uftc8inx 12306 25 , , , cord-010092-uftc8inx 12306 26 the the DT cord-010092-uftc8inx 12306 27 bleeding bleed VBG cord-010092-uftc8inx 12306 28 risk risk NN cord-010092-uftc8inx 12306 29 rises rise VBZ cord-010092-uftc8inx 12306 30 as as RB cord-010092-uftc8inx 12306 31 well well RB cord-010092-uftc8inx 12306 32 . . . cord-010092-uftc8inx 12307 1 Older old JJR cord-010092-uftc8inx 12307 2 patients patient NNS cord-010092-uftc8inx 12307 3 are be VBP cord-010092-uftc8inx 12307 4 more more RBR cord-010092-uftc8inx 12307 5 sensitive sensitive JJ cord-010092-uftc8inx 12307 6 to to IN cord-010092-uftc8inx 12307 7 any any DT cord-010092-uftc8inx 12307 8 given give VBN cord-010092-uftc8inx 12307 9 dose dose NN cord-010092-uftc8inx 12307 10 of of IN cord-010092-uftc8inx 12307 11 warfarin warfarin NN cord-010092-uftc8inx 12307 12 and and CC cord-010092-uftc8inx 12307 13 need need VB cord-010092-uftc8inx 12307 14 a a DT cord-010092-uftc8inx 12307 15 significantly significantly RB cord-010092-uftc8inx 12307 16 lower low JJR cord-010092-uftc8inx 12307 17 total total JJ cord-010092-uftc8inx 12307 18 weekly weekly JJ cord-010092-uftc8inx 12307 19 dose dose NN cord-010092-uftc8inx 12307 20 . . . cord-010092-uftc8inx 12308 1 A a DT cord-010092-uftc8inx 12308 2 well well RB cord-010092-uftc8inx 12308 3 - - HYPH cord-010092-uftc8inx 12308 4 informed inform VBN cord-010092-uftc8inx 12308 5 patient patient NN cord-010092-uftc8inx 12308 6 provides provide VBZ cord-010092-uftc8inx 12308 7 one one CD cord-010092-uftc8inx 12308 8 of of IN cord-010092-uftc8inx 12308 9 the the DT cord-010092-uftc8inx 12308 10 best good JJS cord-010092-uftc8inx 12308 11 defenses defense NNS cord-010092-uftc8inx 12308 12 against against IN cord-010092-uftc8inx 12308 13 bleeding bleed VBG cord-010092-uftc8inx 12308 14 complications complication NNS cord-010092-uftc8inx 12308 15 . . . cord-010092-uftc8inx 12309 1 Recent recent JJ cord-010092-uftc8inx 12309 2 data datum NNS cord-010092-uftc8inx 12309 3 demonstrate demonstrate VBP cord-010092-uftc8inx 12309 4 DOACs doac NNS cord-010092-uftc8inx 12309 5 advantages advantage NNS cord-010092-uftc8inx 12309 6 over over IN cord-010092-uftc8inx 12309 7 warfarin warfarin NN cord-010092-uftc8inx 12309 8 , , , cord-010092-uftc8inx 12309 9 especially especially RB cord-010092-uftc8inx 12309 10 for for IN cord-010092-uftc8inx 12309 11 older old JJR cord-010092-uftc8inx 12309 12 population population NN cord-010092-uftc8inx 12309 13 : : : cord-010092-uftc8inx 12309 14 more more RBR cord-010092-uftc8inx 12309 15 predictable predictable JJ cord-010092-uftc8inx 12309 16 dosing dosing NN cord-010092-uftc8inx 12309 17 , , , cord-010092-uftc8inx 12309 18 fewer few JJR cord-010092-uftc8inx 12309 19 drug drug NN cord-010092-uftc8inx 12309 20 interactions interaction NNS cord-010092-uftc8inx 12309 21 and and CC cord-010092-uftc8inx 12309 22 reduced reduce VBN cord-010092-uftc8inx 12309 23 risk risk NN cord-010092-uftc8inx 12309 24 of of IN cord-010092-uftc8inx 12309 25 intracranial intracranial JJ cord-010092-uftc8inx 12309 26 bleeding bleeding NN cord-010092-uftc8inx 12310 1 Although although IN cord-010092-uftc8inx 12310 2 vast vast JJ cord-010092-uftc8inx 12310 3 majority majority NN cord-010092-uftc8inx 12310 4 of of IN cord-010092-uftc8inx 12310 5 FH FH NNP cord-010092-uftc8inx 12310 6 cases case NNS cord-010092-uftc8inx 12310 7 are be VBP cord-010092-uftc8inx 12310 8 caused cause VBN cord-010092-uftc8inx 12310 9 by by IN cord-010092-uftc8inx 12310 10 mutations mutation NNS cord-010092-uftc8inx 12310 11 in in IN cord-010092-uftc8inx 12310 12 LDL LDL NNP cord-010092-uftc8inx 12310 13 - - HYPH cord-010092-uftc8inx 12310 14 R r NN cord-010092-uftc8inx 12310 15 gene gene NN cord-010092-uftc8inx 12310 16 17%-33 17%-33 CD cord-010092-uftc8inx 12310 17 % % NN cord-010092-uftc8inx 12310 18 patients patient NNS cord-010092-uftc8inx 12310 19 do do VBP cord-010092-uftc8inx 12310 20 not not RB cord-010092-uftc8inx 12310 21 harbor harbor VB cord-010092-uftc8inx 12310 22 genetic genetic JJ cord-010092-uftc8inx 12310 23 cause cause NN cord-010092-uftc8inx 12310 24 in in IN cord-010092-uftc8inx 12310 25 the the DT cord-010092-uftc8inx 12310 26 known know VBN cord-010092-uftc8inx 12310 27 loci locus NNS cord-010092-uftc8inx 12310 28 . . . cord-010092-uftc8inx 12311 1 Patients patient NNS cord-010092-uftc8inx 12311 2 with with IN cord-010092-uftc8inx 12311 3 homozygous homozygous JJ cord-010092-uftc8inx 12311 4 / / SYM cord-010092-uftc8inx 12311 5 severe severe JJ cord-010092-uftc8inx 12311 6 heterozygous heterozygous JJ cord-010092-uftc8inx 12311 7 FH FH NNP cord-010092-uftc8inx 12311 8 are be VBP cord-010092-uftc8inx 12311 9 unresponsive unresponsive JJ cord-010092-uftc8inx 12312 1 ( ( -LRB- cord-010092-uftc8inx 12312 2 LDLc LDLc NNS cord-010092-uftc8inx 12312 3 above above IN cord-010092-uftc8inx 12312 4 200 200 CD cord-010092-uftc8inx 12312 5 mg mg NNP cord-010092-uftc8inx 12312 6 / / SYM cord-010092-uftc8inx 12312 7 dL dl NN cord-010092-uftc8inx 12312 8 with with IN cord-010092-uftc8inx 12312 9 diet diet NN cord-010092-uftc8inx 12312 10 and and CC cord-010092-uftc8inx 12312 11 drug drug NN cord-010092-uftc8inx 12312 12 therapy therapy NN cord-010092-uftc8inx 12312 13 ) ) -RRB- cord-010092-uftc8inx 12312 14 and and CC cord-010092-uftc8inx 12312 15 require require VB cord-010092-uftc8inx 12312 16 additional additional JJ cord-010092-uftc8inx 12312 17 extracorporeal extracorporeal JJ cord-010092-uftc8inx 12312 18 therapy therapy NN cord-010092-uftc8inx 12312 19 to to TO cord-010092-uftc8inx 12312 20 reduce reduce VB cord-010092-uftc8inx 12312 21 LDLc ldlc NN cord-010092-uftc8inx 12312 22 concentrations concentration NNS cord-010092-uftc8inx 12312 23 to to TO cord-010092-uftc8inx 12312 24 prevent prevent VB cord-010092-uftc8inx 12312 25 the the DT cord-010092-uftc8inx 12312 26 development development NN cord-010092-uftc8inx 12312 27 / / SYM cord-010092-uftc8inx 12312 28 progression progression NN cord-010092-uftc8inx 12312 29 of of IN cord-010092-uftc8inx 12312 30 CAD CAD NNP cord-010092-uftc8inx 12312 31 . . . cord-010092-uftc8inx 12313 1 LDL ldl NN cord-010092-uftc8inx 12313 2 apheresis apheresis NN cord-010092-uftc8inx 12313 3 techniques technique NNS cord-010092-uftc8inx 12313 4 remove remove VBP cord-010092-uftc8inx 12313 5 apolipoprotein apolipoprotein NN cord-010092-uftc8inx 12313 6 B b NN cord-010092-uftc8inx 12313 7 - - HYPH cord-010092-uftc8inx 12313 8 containing contain VBG cord-010092-uftc8inx 12313 9 lipoproteins lipoprotein NNS cord-010092-uftc8inx 12313 10 from from IN cord-010092-uftc8inx 12313 11 blood blood NN cord-010092-uftc8inx 12313 12 and and CC cord-010092-uftc8inx 12313 13 include include VBP cord-010092-uftc8inx 12313 14 heparin heparin NN cord-010092-uftc8inx 12313 15 - - HYPH cord-010092-uftc8inx 12313 16 induced induce VBN cord-010092-uftc8inx 12313 17 extracorporeal extracorporeal NN cord-010092-uftc8inx 12313 18 LDL LDL NNP cord-010092-uftc8inx 12313 19 precipitation(HELP precipitation(HELP NNP cord-010092-uftc8inx 12313 20 ) ) -RRB- cord-010092-uftc8inx 12313 21 , , , cord-010092-uftc8inx 12313 22 immunoadsorption immunoadsorption NN cord-010092-uftc8inx 12313 23 , , , cord-010092-uftc8inx 12313 24 dextran dextran NN cord-010092-uftc8inx 12313 25 - - HYPH cord-010092-uftc8inx 12313 26 sulfate sulfate NN cord-010092-uftc8inx 12313 27 adsorption adsorption NN cord-010092-uftc8inx 12313 28 Methods method NNS cord-010092-uftc8inx 12313 29 : : : cord-010092-uftc8inx 12314 1 A a DT cord-010092-uftc8inx 12314 2 28y 28y CD cord-010092-uftc8inx 12314 3 Iraqi iraqi JJ cord-010092-uftc8inx 12314 4 male male NN cord-010092-uftc8inx 12314 5 visited visit VBD cord-010092-uftc8inx 12314 6 Cardiac Cardiac NNP cord-010092-uftc8inx 12314 7 - - HYPH cord-010092-uftc8inx 12314 8 OPD OPD NNP cord-010092-uftc8inx 12314 9 . . . cord-010092-uftc8inx 12315 1 CT CT NNP cord-010092-uftc8inx 12315 2 coronary coronary NN cord-010092-uftc8inx 12315 3 angiogram angiogram NN cord-010092-uftc8inx 12315 4 showed show VBD cord-010092-uftc8inx 12315 5 CAD CAD NNP cord-010092-uftc8inx 12315 6 - - HYPH cord-010092-uftc8inx 12315 7 DVD dvd NN cord-010092-uftc8inx 12315 8 . . . cord-010092-uftc8inx 12316 1 He -PRON- PRP cord-010092-uftc8inx 12316 2 had have VBD cord-010092-uftc8inx 12316 3 multiple multiple JJ cord-010092-uftc8inx 12316 4 tendinous tendinous JJ cord-010092-uftc8inx 12316 5 xanthomas xanthoma NNS cord-010092-uftc8inx 12316 6 and and CC cord-010092-uftc8inx 12316 7 xanthelasmas xanthelasmas NNP cord-010092-uftc8inx 12316 8 . . . cord-010092-uftc8inx 12317 1 Family family NN cord-010092-uftc8inx 12317 2 history history NN cord-010092-uftc8inx 12317 3 was be VBD cord-010092-uftc8inx 12317 4 significant significant JJ cord-010092-uftc8inx 12317 5 for for IN cord-010092-uftc8inx 12317 6 death death NN cord-010092-uftc8inx 12317 7 of of IN cord-010092-uftc8inx 12317 8 elder eld JJR cord-010092-uftc8inx 12317 9 brother brother NN cord-010092-uftc8inx 12317 10 from from IN cord-010092-uftc8inx 12317 11 coronary coronary JJ cord-010092-uftc8inx 12317 12 event event NN cord-010092-uftc8inx 12317 13 at at IN cord-010092-uftc8inx 12317 14 30y 30y CD cord-010092-uftc8inx 12317 15 , , , cord-010092-uftc8inx 12317 16 a a DT cord-010092-uftc8inx 12317 17 sister sister NN cord-010092-uftc8inx 12317 18 with with IN cord-010092-uftc8inx 12317 19 similar similar JJ cord-010092-uftc8inx 12317 20 profile profile NN cord-010092-uftc8inx 12317 21 age age NN cord-010092-uftc8inx 12317 22 26y 26y NNS cord-010092-uftc8inx 12317 23 and and CC cord-010092-uftc8inx 12317 24 one one CD cord-010092-uftc8inx 12317 25 sister sister NN cord-010092-uftc8inx 12317 26 apparently apparently RB cord-010092-uftc8inx 12317 27 normal normal JJ cord-010092-uftc8inx 12317 28 . . . cord-010092-uftc8inx 12318 1 He -PRON- PRP cord-010092-uftc8inx 12318 2 was be VBD cord-010092-uftc8inx 12318 3 taking take VBG cord-010092-uftc8inx 12318 4 medical medical JJ cord-010092-uftc8inx 12318 5 treatment treatment NN cord-010092-uftc8inx 12318 6 for for IN cord-010092-uftc8inx 12318 7 dyslipoproteinemia dyslipoproteinemia NNP cord-010092-uftc8inx 12318 8 ( ( -LRB- cord-010092-uftc8inx 12319 1 Ecosprin Ecosprin NNP cord-010092-uftc8inx 12319 2 75 75 CD cord-010092-uftc8inx 12319 3 mg mg NNP cord-010092-uftc8inx 12319 4 OD OD NNP cord-010092-uftc8inx 12319 5 , , , cord-010092-uftc8inx 12319 6 Ticagrelor Ticagrelor NNP cord-010092-uftc8inx 12319 7 90 90 CD cord-010092-uftc8inx 12319 8 mg mg NN cord-010092-uftc8inx 12319 9 BD BD NNP cord-010092-uftc8inx 12319 10 , , , cord-010092-uftc8inx 12319 11 Rosuvastatin Rosuvastatin NNP cord-010092-uftc8inx 12319 12 40 40 CD cord-010092-uftc8inx 12319 13 mg mg NNP cord-010092-uftc8inx 12319 14 OD OD NNP cord-010092-uftc8inx 12319 15 ) ) -RRB- cord-010092-uftc8inx 12319 16 . . . cord-010092-uftc8inx 12320 1 Despite despite IN cord-010092-uftc8inx 12320 2 dietary dietary JJ cord-010092-uftc8inx 12320 3 and and CC cord-010092-uftc8inx 12320 4 medical medical JJ cord-010092-uftc8inx 12320 5 treatment treatment NN cord-010092-uftc8inx 12320 6 his -PRON- PRP$ cord-010092-uftc8inx 12320 7 dyslipoproteinemia dyslipoproteinemia NN cord-010092-uftc8inx 12320 8 was be VBD cord-010092-uftc8inx 12320 9 refractory refractory JJ cord-010092-uftc8inx 12320 10 . . . cord-010092-uftc8inx 12321 1 Therefore therefore RB cord-010092-uftc8inx 12321 2 Cascade Cascade NNP cord-010092-uftc8inx 12321 3 - - HYPH cord-010092-uftc8inx 12321 4 filtration filtration NN cord-010092-uftc8inx 12321 5 was be VBD cord-010092-uftc8inx 12321 6 planned plan VBN cord-010092-uftc8inx 12321 7 with with IN cord-010092-uftc8inx 12321 8 Evaflux5A Evaflux5A NNP cord-010092-uftc8inx 12321 9 plasma plasma NN cord-010092-uftc8inx 12321 10 fractionator fractionator NN cord-010092-uftc8inx 12321 11 . . . cord-010092-uftc8inx 12322 1 One one CD cord-010092-uftc8inx 12322 2 procedure procedure NN cord-010092-uftc8inx 12322 3 of of IN cord-010092-uftc8inx 12322 4 Cascade Cascade NNP cord-010092-uftc8inx 12322 5 plasmapheresis plasmapheresis NN cord-010092-uftc8inx 12322 6 was be VBD cord-010092-uftc8inx 12322 7 done do VBN cord-010092-uftc8inx 12322 8 on on IN cord-010092-uftc8inx 12322 9 Com Com NNP cord-010092-uftc8inx 12322 10 . . . cord-010092-uftc8inx 12323 1 Tec Tec NNP cord-010092-uftc8inx 12323 2 apheresis apheresis NN cord-010092-uftc8inx 12323 3 system system NN cord-010092-uftc8inx 12323 4 ( ( -LRB- cord-010092-uftc8inx 12323 5 Fresenius Fresenius NNP cord-010092-uftc8inx 12323 6 Kabi Kabi NNP cord-010092-uftc8inx 12323 7 , , , cord-010092-uftc8inx 12323 8 Germany Germany NNP cord-010092-uftc8inx 12323 9 ) ) -RRB- cord-010092-uftc8inx 12323 10 separating separate VBG cord-010092-uftc8inx 12323 11 patient patient NN cord-010092-uftc8inx 12323 12 's 's POS cord-010092-uftc8inx 12323 13 plasma plasma NN cord-010092-uftc8inx 12323 14 as as IN cord-010092-uftc8inx 12323 15 the the DT cord-010092-uftc8inx 12323 16 first first JJ cord-010092-uftc8inx 12323 17 step step NN cord-010092-uftc8inx 12323 18 and and CC cord-010092-uftc8inx 12323 19 passing pass VBG cord-010092-uftc8inx 12323 20 it -PRON- PRP cord-010092-uftc8inx 12323 21 through through IN cord-010092-uftc8inx 12323 22 a a DT cord-010092-uftc8inx 12323 23 pore pore NN cord-010092-uftc8inx 12323 24 sized sized JJ cord-010092-uftc8inx 12323 25 based base VBN cord-010092-uftc8inx 12323 26 filter filter NN cord-010092-uftc8inx 12323 27 column column NN cord-010092-uftc8inx 12323 28 5A20 5a20 CD cord-010092-uftc8inx 12324 1 ( ( -LRB- cord-010092-uftc8inx 12324 2 Evaflux Evaflux NNP cord-010092-uftc8inx 12324 3 , , , cord-010092-uftc8inx 12324 4 Kawasumi Kawasumi NNP cord-010092-uftc8inx 12324 5 , , , cord-010092-uftc8inx 12324 6 Japan Japan NNP cord-010092-uftc8inx 12324 7 ) ) -RRB- cord-010092-uftc8inx 12324 8 as as IN cord-010092-uftc8inx 12324 9 the the DT cord-010092-uftc8inx 12324 10 second second JJ cord-010092-uftc8inx 12324 11 step step NN cord-010092-uftc8inx 12324 12 . . . cord-010092-uftc8inx 12325 1 A a DT cord-010092-uftc8inx 12325 2 total total NN cord-010092-uftc8inx 12325 3 of of IN cord-010092-uftc8inx 12325 4 1.5x 1.5x JJ cord-010092-uftc8inx 12325 5 plasma plasma NN cord-010092-uftc8inx 12325 6 volume(4470 volume(4470 NNP cord-010092-uftc8inx 12325 7 ml ml NNP cord-010092-uftc8inx 12325 8 ) ) -RRB- cord-010092-uftc8inx 12325 9 was be VBD cord-010092-uftc8inx 12325 10 processed process VBN cord-010092-uftc8inx 12325 11 . . . cord-010092-uftc8inx 12326 1 The the DT cord-010092-uftc8inx 12326 2 patient patient NN cord-010092-uftc8inx 12326 3 was be VBD cord-010092-uftc8inx 12326 4 given give VBN cord-010092-uftc8inx 12326 5 continuous continuous JJ cord-010092-uftc8inx 12326 6 calcium calcium NN cord-010092-uftc8inx 12326 7 infusion infusion NN cord-010092-uftc8inx 12326 8 . . . cord-010092-uftc8inx 12327 1 The the DT cord-010092-uftc8inx 12327 2 flow flow NN cord-010092-uftc8inx 12327 3 rate rate NN cord-010092-uftc8inx 12327 4 of of IN cord-010092-uftc8inx 12327 5 50 50 CD cord-010092-uftc8inx 12327 6 ml ml NNS cord-010092-uftc8inx 12327 7 / / SYM cord-010092-uftc8inx 12327 8 min min NNP cord-010092-uftc8inx 12327 9 was be VBD cord-010092-uftc8inx 12327 10 maintained maintain VBN cord-010092-uftc8inx 12327 11 Immunoglobulins Immunoglobulins NNP cord-010092-uftc8inx 12327 12 ) ) -RRB- cord-010092-uftc8inx 12327 13 were be VBD cord-010092-uftc8inx 12327 14 not not RB cord-010092-uftc8inx 12327 15 assessed assess VBN cord-010092-uftc8inx 12327 16 . . . cord-010092-uftc8inx 12328 1 Summary Summary NNP cord-010092-uftc8inx 12328 2 / / SYM cord-010092-uftc8inx 12328 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 12328 4 : : : cord-010092-uftc8inx 12329 1 The the DT cord-010092-uftc8inx 12329 2 procedure procedure NN cord-010092-uftc8inx 12329 3 successfully successfully RB cord-010092-uftc8inx 12329 4 met meet VBD cord-010092-uftc8inx 12329 5 the the DT cord-010092-uftc8inx 12329 6 requirement requirement NN cord-010092-uftc8inx 12329 7 of of IN cord-010092-uftc8inx 12329 8 reduction reduction NN cord-010092-uftc8inx 12329 9 of of IN cord-010092-uftc8inx 12329 10 cholesterol cholesterol NN cord-010092-uftc8inx 12329 11 by by IN cord-010092-uftc8inx 12329 12 60 60 CD cord-010092-uftc8inx 12329 13 % % NN cord-010092-uftc8inx 12329 14 . . . cord-010092-uftc8inx 12330 1 The the DT cord-010092-uftc8inx 12330 2 patient patient NN cord-010092-uftc8inx 12330 3 became become VBD cord-010092-uftc8inx 12330 4 responsive responsive JJ cord-010092-uftc8inx 12330 5 to to IN cord-010092-uftc8inx 12330 6 the the DT cord-010092-uftc8inx 12330 7 medical medical JJ cord-010092-uftc8inx 12330 8 treatment treatment NN cord-010092-uftc8inx 12330 9 . . . cord-010092-uftc8inx 12331 1 Follow follow VB cord-010092-uftc8inx 12331 2 up up IN cord-010092-uftc8inx 12331 3 of of IN cord-010092-uftc8inx 12331 4 the the DT cord-010092-uftc8inx 12331 5 patient patient NN cord-010092-uftc8inx 12331 6 up up IN cord-010092-uftc8inx 12331 7 to to IN cord-010092-uftc8inx 12331 8 a a DT cord-010092-uftc8inx 12331 9 year year NN cord-010092-uftc8inx 12331 10 has have VBZ cord-010092-uftc8inx 12331 11 been be VBN cord-010092-uftc8inx 12331 12 uneventful uneventful JJ cord-010092-uftc8inx 12331 13 with with IN cord-010092-uftc8inx 12331 14 no no DT cord-010092-uftc8inx 12331 15 additional additional JJ cord-010092-uftc8inx 12331 16 procedure procedure NN cord-010092-uftc8inx 12331 17 requirement requirement NN cord-010092-uftc8inx 12331 18 Actions action NNS cord-010092-uftc8inx 12331 19 included include VBD cord-010092-uftc8inx 12331 20 development development NN cord-010092-uftc8inx 12331 21 of of IN cord-010092-uftc8inx 12331 22 major major JJ cord-010092-uftc8inx 12331 23 haemorrhage haemorrhage NN cord-010092-uftc8inx 12331 24 protocols protocol NNS cord-010092-uftc8inx 12331 25 with with IN cord-010092-uftc8inx 12331 26 improved improved JJ cord-010092-uftc8inx 12331 27 communication communication NN cord-010092-uftc8inx 12331 28 and and CC cord-010092-uftc8inx 12331 29 required require VBN cord-010092-uftc8inx 12331 30 instances instance NNS cord-010092-uftc8inx 12331 31 of of IN cord-010092-uftc8inx 12331 32 delayed delayed JJ cord-010092-uftc8inx 12331 33 transfusion transfusion NN cord-010092-uftc8inx 12331 34 to to TO cord-010092-uftc8inx 12331 35 be be VB cord-010092-uftc8inx 12331 36 reported report VBN cord-010092-uftc8inx 12331 37 to to IN cord-010092-uftc8inx 12331 38 the the DT cord-010092-uftc8inx 12331 39 UK UK NNP cord-010092-uftc8inx 12331 40 national national JJ cord-010092-uftc8inx 12331 41 haemovigilance haemovigilance NN cord-010092-uftc8inx 12331 42 scheme scheme NN cord-010092-uftc8inx 12331 43 ( ( -LRB- cord-010092-uftc8inx 12331 44 Serious Serious NNP cord-010092-uftc8inx 12331 45 Hazards Hazards NNPS cord-010092-uftc8inx 12331 46 of of IN cord-010092-uftc8inx 12331 47 Transfusion Transfusion NNP cord-010092-uftc8inx 12331 48 , , , cord-010092-uftc8inx 12332 1 SHOT SHOT NNP cord-010092-uftc8inx 12332 2 ) ) -RRB- cord-010092-uftc8inx 12332 3 Methods method NNS cord-010092-uftc8inx 12332 4 : : : cord-010092-uftc8inx 12332 5 Delayed delay VBN cord-010092-uftc8inx 12332 6 transfusion transfusion NN cord-010092-uftc8inx 12332 7 data datum NNS cord-010092-uftc8inx 12332 8 have have VBP cord-010092-uftc8inx 12332 9 been be VBN cord-010092-uftc8inx 12332 10 collected collect VBN cord-010092-uftc8inx 12332 11 from from IN cord-010092-uftc8inx 12332 12 2010 2010 CD cord-010092-uftc8inx 12332 13 . . . cord-010092-uftc8inx 12333 1 Hospitals hospital NNS cord-010092-uftc8inx 12333 2 identify identify VBP cord-010092-uftc8inx 12333 3 incidents incident NNS cord-010092-uftc8inx 12333 4 and and CC cord-010092-uftc8inx 12333 5 report report VB cord-010092-uftc8inx 12333 6 them -PRON- PRP cord-010092-uftc8inx 12333 7 via via IN cord-010092-uftc8inx 12333 8 an an DT cord-010092-uftc8inx 12333 9 online online JJ cord-010092-uftc8inx 12333 10 database database NN cord-010092-uftc8inx 12333 11 . . . cord-010092-uftc8inx 12334 1 MH MH NNP cord-010092-uftc8inx 12334 2 may may MD cord-010092-uftc8inx 12334 3 also also RB cord-010092-uftc8inx 12334 4 result result VB cord-010092-uftc8inx 12334 5 in in IN cord-010092-uftc8inx 12334 6 avoidable avoidable JJ cord-010092-uftc8inx 12334 7 or or CC cord-010092-uftc8inx 12334 8 overtransfusion overtransfusion NN cord-010092-uftc8inx 12334 9 . . . cord-010092-uftc8inx 12335 1 Reports report NNS cord-010092-uftc8inx 12335 2 are be VBP cord-010092-uftc8inx 12335 3 analysed analyse VBN cord-010092-uftc8inx 12335 4 and and CC cord-010092-uftc8inx 12335 5 collated collate VBN cord-010092-uftc8inx 12335 6 data datum NNS cord-010092-uftc8inx 12335 7 published publish VBN cord-010092-uftc8inx 12335 8 in in IN cord-010092-uftc8inx 12335 9 the the DT cord-010092-uftc8inx 12335 10 SHOT SHOT NNP cord-010092-uftc8inx 12335 11 annual annual JJ cord-010092-uftc8inx 12335 12 reports report NNS cord-010092-uftc8inx 12335 13 in in IN cord-010092-uftc8inx 12335 14 July July NNP cord-010092-uftc8inx 12335 15 each each DT cord-010092-uftc8inx 12335 16 year year NN cord-010092-uftc8inx 12335 17 . . . cord-010092-uftc8inx 12336 1 Results result NNS cord-010092-uftc8inx 12336 2 : : : cord-010092-uftc8inx 12337 1 The the DT cord-010092-uftc8inx 12337 2 total total JJ cord-010092-uftc8inx 12337 3 number number NN cord-010092-uftc8inx 12337 4 of of IN cord-010092-uftc8inx 12337 5 reports report NNS cord-010092-uftc8inx 12337 6 of of IN cord-010092-uftc8inx 12337 7 delayed delay VBN cord-010092-uftc8inx 12337 8 transfusion transfusion NN cord-010092-uftc8inx 12337 9 has have VBZ cord-010092-uftc8inx 12337 10 increased increase VBN cord-010092-uftc8inx 12337 11 with with IN cord-010092-uftc8inx 12337 12 time time NN cord-010092-uftc8inx 12337 13 : : : cord-010092-uftc8inx 12337 14 101 101 CD cord-010092-uftc8inx 12337 15 , , , cord-010092-uftc8inx 12337 16 95 95 CD cord-010092-uftc8inx 12337 17 , , , cord-010092-uftc8inx 12337 18 111 111 CD cord-010092-uftc8inx 12337 19 in in IN cord-010092-uftc8inx 12337 20 the the DT cord-010092-uftc8inx 12337 21 last last JJ cord-010092-uftc8inx 12337 22 3 3 CD cord-010092-uftc8inx 12337 23 years year NNS cord-010092-uftc8inx 12337 24 . . . cord-010092-uftc8inx 12338 1 Delayed delay VBN cord-010092-uftc8inx 12338 2 transfusion transfusion NN cord-010092-uftc8inx 12338 3 in in IN cord-010092-uftc8inx 12338 4 relation relation NN cord-010092-uftc8inx 12338 5 to to IN cord-010092-uftc8inx 12338 6 MH MH NNP cord-010092-uftc8inx 12338 7 was be VBD cord-010092-uftc8inx 12338 8 reported report VBN cord-010092-uftc8inx 12338 9 for for IN cord-010092-uftc8inx 12338 10 54 54 CD cord-010092-uftc8inx 12338 11 cases case NNS cord-010092-uftc8inx 12338 12 2016 2016 CD cord-010092-uftc8inx 12338 13 - - SYM cord-010092-uftc8inx 12338 14 2018 2018 CD cord-010092-uftc8inx 12338 15 contributing contribute VBG cord-010092-uftc8inx 12338 16 to to IN cord-010092-uftc8inx 12338 17 death death NN cord-010092-uftc8inx 12338 18 in in IN cord-010092-uftc8inx 12338 19 6 6 CD cord-010092-uftc8inx 12338 20 patients patient NNS cord-010092-uftc8inx 12338 21 7 7 CD cord-010092-uftc8inx 12338 22 % % NN cord-010092-uftc8inx 12338 23 ) ) -RRB- cord-010092-uftc8inx 12339 1 miscommunication miscommunication NN cord-010092-uftc8inx 12339 2 was be VBD cord-010092-uftc8inx 12339 3 noted note VBN cord-010092-uftc8inx 12339 4 between between IN cord-010092-uftc8inx 12339 5 clinical clinical JJ cord-010092-uftc8inx 12339 6 different different JJ cord-010092-uftc8inx 12339 7 teams team NNS cord-010092-uftc8inx 12339 8 , , , cord-010092-uftc8inx 12339 9 between between IN cord-010092-uftc8inx 12339 10 emergency emergency NN cord-010092-uftc8inx 12339 11 departments department NNS cord-010092-uftc8inx 12339 12 , , , cord-010092-uftc8inx 12339 13 porters porter NNS cord-010092-uftc8inx 12339 14 and and CC cord-010092-uftc8inx 12339 15 the the DT cord-010092-uftc8inx 12339 16 transfusion transfusion NN cord-010092-uftc8inx 12339 17 laboratory laboratory NN cord-010092-uftc8inx 12339 18 , , , cord-010092-uftc8inx 12339 19 failure failure NN cord-010092-uftc8inx 12339 20 of of IN cord-010092-uftc8inx 12339 21 bleeps bleep NNS cord-010092-uftc8inx 12339 22 , , , cord-010092-uftc8inx 12339 23 failure failure NN cord-010092-uftc8inx 12339 24 to to TO cord-010092-uftc8inx 12339 25 communicate communicate VB cord-010092-uftc8inx 12339 26 the the DT cord-010092-uftc8inx 12339 27 urgency urgency NN cord-010092-uftc8inx 12339 28 , , , cord-010092-uftc8inx 12339 29 failure failure NN cord-010092-uftc8inx 12339 30 to to TO cord-010092-uftc8inx 12339 31 confirm confirm VB cord-010092-uftc8inx 12339 32 the the DT cord-010092-uftc8inx 12339 33 patient patient JJ cord-010092-uftc8inx 12339 34 location location NN cord-010092-uftc8inx 12339 35 . . . cord-010092-uftc8inx 12340 1 Failures failure NNS cord-010092-uftc8inx 12340 2 to to TO cord-010092-uftc8inx 12340 3 follow follow VB cord-010092-uftc8inx 12340 4 MHP MHP NNP cord-010092-uftc8inx 12340 5 correctly correctly RB cord-010092-uftc8inx 12340 6 occurred occur VBD cord-010092-uftc8inx 12340 7 in in IN cord-010092-uftc8inx 12340 8 31/71 31/71 CD cord-010092-uftc8inx 12340 9 ( ( -LRB- cord-010092-uftc8inx 12340 10 43.7 43.7 CD cord-010092-uftc8inx 12340 11 % % NN cord-010092-uftc8inx 12340 12 ) ) -RRB- cord-010092-uftc8inx 12340 13 : : : cord-010092-uftc8inx 12340 14 incorrect incorrect JJ cord-010092-uftc8inx 12340 15 activation activation NN cord-010092-uftc8inx 12340 16 including include VBG cord-010092-uftc8inx 12340 17 failed fail VBD cord-010092-uftc8inx 12340 18 alerts alert NNS cord-010092-uftc8inx 12340 19 to to IN cord-010092-uftc8inx 12340 20 porters porter NNS cord-010092-uftc8inx 12340 21 , , , cord-010092-uftc8inx 12340 22 wrong wrong JJ cord-010092-uftc8inx 12340 23 contact contact NN cord-010092-uftc8inx 12340 24 telephone telephone NN cord-010092-uftc8inx 12340 25 details detail NNS cord-010092-uftc8inx 12340 26 and and CC cord-010092-uftc8inx 12340 27 wrong wrong JJ cord-010092-uftc8inx 12340 28 components component NNS cord-010092-uftc8inx 12340 29 in in IN cord-010092-uftc8inx 12340 30 the the DT cord-010092-uftc8inx 12340 31 MHP MHP NNP cord-010092-uftc8inx 12340 32 packs pack NNS cord-010092-uftc8inx 12341 1 Most Most JJS cord-010092-uftc8inx 12341 2 transfusions transfusion NNS cord-010092-uftc8inx 12341 3 included include VBD cord-010092-uftc8inx 12341 4 red red JJ cord-010092-uftc8inx 12341 5 blood blood NN cord-010092-uftc8inx 12341 6 cells cell NNS cord-010092-uftc8inx 12341 7 ( ( -LRB- cord-010092-uftc8inx 12341 8 median median NN cord-010092-uftc8inx 12341 9 , , , cord-010092-uftc8inx 12341 10 2 2 CD cord-010092-uftc8inx 12341 11 units unit NNS cord-010092-uftc8inx 12341 12 ) ) -RRB- cord-010092-uftc8inx 12341 13 ; ; : cord-010092-uftc8inx 12341 14 14 14 CD cord-010092-uftc8inx 12341 15 % % NN cord-010092-uftc8inx 12341 16 of of IN cord-010092-uftc8inx 12341 17 women woman NNS cord-010092-uftc8inx 12341 18 were be VBD cord-010092-uftc8inx 12341 19 transfused transfuse VBN cord-010092-uftc8inx 12341 20 with with IN cord-010092-uftc8inx 12341 21 fresh fresh JJ cord-010092-uftc8inx 12341 22 frozen frozen JJ cord-010092-uftc8inx 12341 23 plasma plasma NN cord-010092-uftc8inx 12341 24 ( ( -LRB- cord-010092-uftc8inx 12341 25 median median NN cord-010092-uftc8inx 12341 26 , , , cord-010092-uftc8inx 12341 27 2 2 CD cord-010092-uftc8inx 12341 28 units unit NNS cord-010092-uftc8inx 12341 29 ) ) -RRB- cord-010092-uftc8inx 12341 30 and and CC cord-010092-uftc8inx 12341 31 2 2 CD cord-010092-uftc8inx 12341 32 % % NN cord-010092-uftc8inx 12341 33 with with IN cord-010092-uftc8inx 12341 34 platelets platelet NNS cord-010092-uftc8inx 12341 35 . . . cord-010092-uftc8inx 12342 1 Mean mean JJ cord-010092-uftc8inx 12342 2 pre pre JJ cord-010092-uftc8inx 12342 3 - - JJ cord-010092-uftc8inx 12342 4 and and CC cord-010092-uftc8inx 12342 5 post post JJ cord-010092-uftc8inx 12342 6 - - JJ cord-010092-uftc8inx 12342 7 transfusion transfusion JJ cord-010092-uftc8inx 12342 8 hemoglobin hemoglobin NN cord-010092-uftc8inx 12342 9 levels level NNS cord-010092-uftc8inx 12342 10 were be VBD cord-010092-uftc8inx 12342 11 6.7 6.7 CD cord-010092-uftc8inx 12342 12 g g NN cord-010092-uftc8inx 12342 13 / / SYM cord-010092-uftc8inx 12342 14 dL dl NN cord-010092-uftc8inx 12342 15 and and CC cord-010092-uftc8inx 12342 16 9.0 9.0 CD cord-010092-uftc8inx 12342 17 g g NN cord-010092-uftc8inx 12342 18 / / SYM cord-010092-uftc8inx 12342 19 dL dl NN cord-010092-uftc8inx 12342 20 , , , cord-010092-uftc8inx 12342 21 respectively respectively RB cord-010092-uftc8inx 12342 22 , , , cord-010092-uftc8inx 12342 23 representing represent VBG cord-010092-uftc8inx 12342 24 an an DT cord-010092-uftc8inx 12342 25 increment increment NN cord-010092-uftc8inx 12342 26 of of IN cord-010092-uftc8inx 12342 27 1.0 1.0 CD cord-010092-uftc8inx 12342 28 g g NN cord-010092-uftc8inx 12342 29 / / SYM cord-010092-uftc8inx 12342 30 dL dl NN cord-010092-uftc8inx 12342 31 per per IN cord-010092-uftc8inx 12342 32 RBC RBC NNP cord-010092-uftc8inx 12342 33 unit unit NN cord-010092-uftc8inx 12342 34 transfused transfuse VBN cord-010092-uftc8inx 12342 35 ( ( -LRB- cord-010092-uftc8inx 12342 36 1.09 1.09 CD cord-010092-uftc8inx 12342 37 g g NN cord-010092-uftc8inx 12342 38 / / SYM cord-010092-uftc8inx 12342 39 dL dl NN cord-010092-uftc8inx 12342 40 in in IN cord-010092-uftc8inx 12342 41 Soweto Soweto NNP cord-010092-uftc8inx 12342 42 and and CC cord-010092-uftc8inx 12342 43 0.83 0.83 CD cord-010092-uftc8inx 12342 44 g g NN cord-010092-uftc8inx 12342 45 / / SYM cord-010092-uftc8inx 12342 46 dL dl NN cord-010092-uftc8inx 12342 47 in in IN cord-010092-uftc8inx 12342 48 Durban Durban NNP cord-010092-uftc8inx 12342 49 ) ) -RRB- cord-010092-uftc8inx 12342 50 . . . cord-010092-uftc8inx 12343 1 Indications indication NNS cord-010092-uftc8inx 12343 2 for for IN cord-010092-uftc8inx 12343 3 transfusion transfusion NN cord-010092-uftc8inx 12343 4 included include VBD cord-010092-uftc8inx 12343 5 obstetric obstetric JJ cord-010092-uftc8inx 12343 6 hemorrhage hemorrhage NN cord-010092-uftc8inx 12343 7 ( ( -LRB- cord-010092-uftc8inx 12343 8 31 31 CD cord-010092-uftc8inx 12343 9 % % NN cord-010092-uftc8inx 12343 10 ) ) -RRB- cord-010092-uftc8inx 12343 11 , , , cord-010092-uftc8inx 12343 12 chronic chronic JJ cord-010092-uftc8inx 12343 13 anemia anemia NN cord-010092-uftc8inx 12343 14 ( ( -LRB- cord-010092-uftc8inx 12343 15 29 29 CD cord-010092-uftc8inx 12343 16 % % NN cord-010092-uftc8inx 12343 17 ) ) -RRB- cord-010092-uftc8inx 12343 18 , , , cord-010092-uftc8inx 12343 19 surgery surgery NN cord-010092-uftc8inx 12343 20 or or CC cord-010092-uftc8inx 12343 21 anesthesia anesthesia NN cord-010092-uftc8inx 12343 22 ( ( -LRB- cord-010092-uftc8inx 12343 23 13 13 CD cord-010092-uftc8inx 12343 24 % % NN cord-010092-uftc8inx 12343 25 ) ) -RRB- cord-010092-uftc8inx 12343 26 , , , cord-010092-uftc8inx 12343 27 other other JJ cord-010092-uftc8inx 12343 28 ( ( -LRB- cord-010092-uftc8inx 12343 29 9 9 CD cord-010092-uftc8inx 12343 30 % % NN cord-010092-uftc8inx 12343 31 ) ) -RRB- cord-010092-uftc8inx 12343 32 and and CC cord-010092-uftc8inx 12343 33 not not RB cord-010092-uftc8inx 12343 34 specified specify VBN cord-010092-uftc8inx 12343 35 ( ( -LRB- cord-010092-uftc8inx 12343 36 17 17 CD cord-010092-uftc8inx 12343 37 % % NN cord-010092-uftc8inx 12343 38 ) ) -RRB- cord-010092-uftc8inx 12343 39 . . . cord-010092-uftc8inx 12344 1 Transfusion transfusion NN cord-010092-uftc8inx 12344 2 for for IN cord-010092-uftc8inx 12344 3 chronic chronic JJ cord-010092-uftc8inx 12344 4 anemia anemia NN cord-010092-uftc8inx 12344 5 ( ( -LRB- cord-010092-uftc8inx 12344 6 vs. vs. FW cord-010092-uftc8inx 12344 7 hemorrhage hemorrhage NN cord-010092-uftc8inx 12344 8 ) ) -RRB- cord-010092-uftc8inx 12344 9 was be VBD cord-010092-uftc8inx 12344 10 associated associate VBN cord-010092-uftc8inx 12344 11 with with IN cord-010092-uftc8inx 12344 12 gestation gestation NN cord-010092-uftc8inx 12344 13 ≥ ≥ CD cord-010092-uftc8inx 12344 14 26 26 CD cord-010092-uftc8inx 12344 15 weeks week NNS cord-010092-uftc8inx 12344 16 ( ( -LRB- cord-010092-uftc8inx 12344 17 odds odd NNS cord-010092-uftc8inx 12344 18 ratio ratio NN cord-010092-uftc8inx 12344 19 = = SYM cord-010092-uftc8inx 12344 20 7.07 7.07 CD cord-010092-uftc8inx 12344 21 , , , cord-010092-uftc8inx 12344 22 95 95 CD cord-010092-uftc8inx 12344 23 % % NN cord-010092-uftc8inx 12344 24 confidence confidence NN cord-010092-uftc8inx 12344 25 interval interval NN cord-010092-uftc8inx 12344 26 3.52 3.52 CD cord-010092-uftc8inx 12344 27 - - SYM cord-010092-uftc8inx 12344 28 14.24 14.24 CD cord-010092-uftc8inx 12344 29 ) ) -RRB- cord-010092-uftc8inx 12344 30 . . . cord-010092-uftc8inx 12345 1 Surgical surgical JJ cord-010092-uftc8inx 12345 2 blood blood NN cord-010092-uftc8inx 12345 3 loss loss NN cord-010092-uftc8inx 12345 4 was be VBD cord-010092-uftc8inx 12345 5 a a DT cord-010092-uftc8inx 12345 6 common common JJ cord-010092-uftc8inx 12345 7 indication indication NN cord-010092-uftc8inx 12345 8 in in IN cord-010092-uftc8inx 12345 9 trimester trimester NN cord-010092-uftc8inx 12345 10 1 1 CD cord-010092-uftc8inx 12345 11 ( ( -LRB- cord-010092-uftc8inx 12345 12 21 21 CD cord-010092-uftc8inx 12345 13 % % NN cord-010092-uftc8inx 12345 14 ) ) -RRB- cord-010092-uftc8inx 12345 15 that that WDT cord-010092-uftc8inx 12345 16 declined decline VBD cord-010092-uftc8inx 12345 17 to to IN cord-010092-uftc8inx 12345 18 7 7 CD cord-010092-uftc8inx 12345 19 % % NN cord-010092-uftc8inx 12345 20 then then RB cord-010092-uftc8inx 12345 21 1 1 CD cord-010092-uftc8inx 12345 22 % % NN cord-010092-uftc8inx 12345 23 in in IN cord-010092-uftc8inx 12345 24 trimesters trimester NNS cord-010092-uftc8inx 12345 25 2 2 CD cord-010092-uftc8inx 12345 26 and and CC cord-010092-uftc8inx 12345 27 3 3 CD cord-010092-uftc8inx 12345 28 . . . cord-010092-uftc8inx 12346 1 Summary Summary NNP cord-010092-uftc8inx 12346 2 / / SYM cord-010092-uftc8inx 12346 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 12346 4 : : : cord-010092-uftc8inx 12347 1 Hemorrhagic hemorrhagic JJ cord-010092-uftc8inx 12347 2 complications complication NNS cord-010092-uftc8inx 12347 3 accompanying accompany VBG cord-010092-uftc8inx 12347 4 spontaneous spontaneous JJ cord-010092-uftc8inx 12347 5 abortions abortion NNS cord-010092-uftc8inx 12347 6 and and CC cord-010092-uftc8inx 12347 7 ectopic ectopic JJ cord-010092-uftc8inx 12347 8 pregnancies pregnancy NNS cord-010092-uftc8inx 12347 9 in in IN cord-010092-uftc8inx 12347 10 the the DT cord-010092-uftc8inx 12347 11 first first JJ cord-010092-uftc8inx 12347 12 and and CC cord-010092-uftc8inx 12347 13 second second JJ cord-010092-uftc8inx 12347 14 trimesters trimester NNS cord-010092-uftc8inx 12347 15 were be VBD cord-010092-uftc8inx 12347 16 the the DT cord-010092-uftc8inx 12347 17 most most RBS cord-010092-uftc8inx 12347 18 common common JJ cord-010092-uftc8inx 12347 19 reasons reason NNS cord-010092-uftc8inx 12347 20 for for IN cord-010092-uftc8inx 12347 21 antenatal antenatal JJ cord-010092-uftc8inx 12347 22 transfusion transfusion NN cord-010092-uftc8inx 12347 23 Surveillance surveillance NN cord-010092-uftc8inx 12347 24 and and CC cord-010092-uftc8inx 12347 25 analysis analysis NN cord-010092-uftc8inx 12347 26 of of IN cord-010092-uftc8inx 12347 27 blood blood NN cord-010092-uftc8inx 12347 28 transfusion transfusion NN cord-010092-uftc8inx 12347 29 reactions reaction NNS cord-010092-uftc8inx 12347 30 represents represent VBZ cord-010092-uftc8inx 12347 31 inseparable inseparable JJ cord-010092-uftc8inx 12347 32 part part NN cord-010092-uftc8inx 12347 33 of of IN cord-010092-uftc8inx 12347 34 hemovigilance hemovigilance NN cord-010092-uftc8inx 12347 35 . . . cord-010092-uftc8inx 12348 1 Aims aim VBZ cord-010092-uftc8inx 12348 2 : : : cord-010092-uftc8inx 12348 3 Summarization Summarization NNP cord-010092-uftc8inx 12348 4 of of IN cord-010092-uftc8inx 12348 5 data datum NNS cord-010092-uftc8inx 12348 6 on on IN cord-010092-uftc8inx 12348 7 reported report VBN cord-010092-uftc8inx 12348 8 cases case NNS cord-010092-uftc8inx 12348 9 of of IN cord-010092-uftc8inx 12348 10 transfusion transfusion NN cord-010092-uftc8inx 12348 11 reactions reaction NNS cord-010092-uftc8inx 12348 12 . . . cord-010092-uftc8inx 12349 1 Methods method NNS cord-010092-uftc8inx 12349 2 : : : cord-010092-uftc8inx 12349 3 Analysis analysis NN cord-010092-uftc8inx 12349 4 of of IN cord-010092-uftc8inx 12349 5 serious serious JJ cord-010092-uftc8inx 12349 6 undesirable undesirable JJ cord-010092-uftc8inx 12349 7 reactions reaction NNS cord-010092-uftc8inx 12349 8 to to IN cord-010092-uftc8inx 12349 9 blood blood NN cord-010092-uftc8inx 12349 10 products product NNS cord-010092-uftc8inx 12349 11 administration administration NN cord-010092-uftc8inx 12349 12 in in IN cord-010092-uftc8inx 12349 13 the the DT cord-010092-uftc8inx 12349 14 Czech Czech NNP cord-010092-uftc8inx 12349 15 Republic Republic NNP cord-010092-uftc8inx 12349 16 ( ( -LRB- cord-010092-uftc8inx 12349 17 CR CR NNP cord-010092-uftc8inx 12349 18 ) ) -RRB- cord-010092-uftc8inx 12349 19 during during IN cord-010092-uftc8inx 12349 20 period period NN cord-010092-uftc8inx 12349 21 2016 2016 CD cord-010092-uftc8inx 12349 22 - - SYM cord-010092-uftc8inx 12349 23 2018 2018 CD cord-010092-uftc8inx 12349 24 . . . cord-010092-uftc8inx 12350 1 Results result NNS cord-010092-uftc8inx 12350 2 : : : cord-010092-uftc8inx 12351 1 There there EX cord-010092-uftc8inx 12351 2 were be VBD cord-010092-uftc8inx 12351 3 evaluated evaluate VBN cord-010092-uftc8inx 12351 4 1,281 1,281 CD cord-010092-uftc8inx 12351 5 688 688 CD cord-010092-uftc8inx 12351 6 of of IN cord-010092-uftc8inx 12351 7 blood blood NN cord-010092-uftc8inx 12351 8 products product NNS cord-010092-uftc8inx 12351 9 administrations administration NNS cord-010092-uftc8inx 12351 10 in in IN cord-010092-uftc8inx 12351 11 117,414 117,414 CD cord-010092-uftc8inx 12351 12 patients patient NNS cord-010092-uftc8inx 12351 13 in in IN cord-010092-uftc8inx 12351 14 the the DT cord-010092-uftc8inx 12351 15 CR cr NN cord-010092-uftc8inx 12351 16 during during IN cord-010092-uftc8inx 12351 17 defined define VBN cord-010092-uftc8inx 12351 18 three three CD cord-010092-uftc8inx 12351 19 years year NNS cord-010092-uftc8inx 12351 20 period period NN cord-010092-uftc8inx 12351 21 . . . cord-010092-uftc8inx 12352 1 Announced announce VBN cord-010092-uftc8inx 12352 2 1,456 1,456 CD cord-010092-uftc8inx 12352 3 ( ( -LRB- cord-010092-uftc8inx 12352 4 0,11 0,11 CD cord-010092-uftc8inx 12352 5 % % NN cord-010092-uftc8inx 12352 6 ) ) -RRB- cord-010092-uftc8inx 12352 7 transfusion transfusion NN cord-010092-uftc8inx 12352 8 reactions reaction NNS cord-010092-uftc8inx 12352 9 including include VBG cord-010092-uftc8inx 12352 10 50 50 CD cord-010092-uftc8inx 12352 11 severe severe JJ cord-010092-uftc8inx 12352 12 transfusion transfusion NN cord-010092-uftc8inx 12352 13 reactions reaction NNS cord-010092-uftc8inx 12352 14 ( ( -LRB- cord-010092-uftc8inx 12352 15 20 20 CD cord-010092-uftc8inx 12352 16 9 9 CD cord-010092-uftc8inx 12352 17 adjudged adjudge VBN cord-010092-uftc8inx 12352 18 with with IN cord-010092-uftc8inx 12352 19 grade grade NN cord-010092-uftc8inx 12352 20 3 3 CD cord-010092-uftc8inx 12352 21 ) ) -RRB- cord-010092-uftc8inx 12352 22 . . . cord-010092-uftc8inx 12353 1 The the DT cord-010092-uftc8inx 12353 2 most most RBS cord-010092-uftc8inx 12353 3 frequent frequent JJ cord-010092-uftc8inx 12353 4 types type NNS cord-010092-uftc8inx 12353 5 of of IN cord-010092-uftc8inx 12353 6 severe severe JJ cord-010092-uftc8inx 12353 7 transfusion transfusion NN cord-010092-uftc8inx 12353 8 reactions reaction NNS cord-010092-uftc8inx 12353 9 : : : cord-010092-uftc8inx 12353 10 Anaphylaxis anaphylaxis NN cord-010092-uftc8inx 12353 11 20 20 CD cord-010092-uftc8inx 12353 12 , , , cord-010092-uftc8inx 12353 13 TRALI TRALI NNP cord-010092-uftc8inx 12353 14 7x 7x CD cord-010092-uftc8inx 12353 15 , , , cord-010092-uftc8inx 12353 16 TACO TACO NNP cord-010092-uftc8inx 12353 17 5x 5x CD cord-010092-uftc8inx 12353 18 , , , cord-010092-uftc8inx 12353 19 HCV HCV NNP cord-010092-uftc8inx 12353 20 4x 4x CD cord-010092-uftc8inx 12353 21 , , , cord-010092-uftc8inx 12353 22 HBC HBC NNP cord-010092-uftc8inx 12353 23 2x 2x CD cord-010092-uftc8inx 12353 24 , , , cord-010092-uftc8inx 12353 25 bacterial bacterial JJ cord-010092-uftc8inx 12353 26 infection infection NN cord-010092-uftc8inx 12353 27 1x 1x CD cord-010092-uftc8inx 12353 28 , , , cord-010092-uftc8inx 12353 29 delayed delay VBN cord-010092-uftc8inx 12353 30 hemolysis hemolysis NN cord-010092-uftc8inx 12353 31 1x 1x CD cord-010092-uftc8inx 12353 32 . . . cord-010092-uftc8inx 12354 1 Transfusion transfusion NN cord-010092-uftc8inx 12354 2 reactions reaction NNS cord-010092-uftc8inx 12354 3 incidence incidence NN cord-010092-uftc8inx 12354 4 according accord VBG cord-010092-uftc8inx 12354 5 to to IN cord-010092-uftc8inx 12354 6 administered administer VBN cord-010092-uftc8inx 12354 7 BP BP NNP cord-010092-uftc8inx 12354 8 : : : cord-010092-uftc8inx 12354 9 Red red JJ cord-010092-uftc8inx 12354 10 blood blood NN cord-010092-uftc8inx 12354 11 cells cell NNS cord-010092-uftc8inx 12354 12 products product NNS cord-010092-uftc8inx 12354 13 : : : cord-010092-uftc8inx 12354 14 882,017 882,017 CD cord-010092-uftc8inx 12354 15 administrations administration NNS cord-010092-uftc8inx 12354 16 , , , cord-010092-uftc8inx 12354 17 883 883 CD cord-010092-uftc8inx 12354 18 transfusion transfusion NN cord-010092-uftc8inx 12354 19 reactions reaction NNS cord-010092-uftc8inx 12354 20 ( ( -LRB- cord-010092-uftc8inx 12354 21 FNHTR FNHTR NNP cord-010092-uftc8inx 12354 22 386x 386x CD cord-010092-uftc8inx 12354 23 , , , cord-010092-uftc8inx 12354 24 Allergy allergy NN cord-010092-uftc8inx 12354 25 227x 227x NNS cord-010092-uftc8inx 12354 26 , , , cord-010092-uftc8inx 12354 27 circulatory circulatory JJ cord-010092-uftc8inx 12354 28 overload overload NN cord-010092-uftc8inx 12354 29 66x 66x NNS cord-010092-uftc8inx 12354 30 , , , cord-010092-uftc8inx 12355 1 anaphylaxis anaphylaxis NN cord-010092-uftc8inx 12355 2 6x 6x CD cord-010092-uftc8inx 12355 3 , , , cord-010092-uftc8inx 12355 4 TRALI TRALI NNP cord-010092-uftc8inx 12355 5 4x 4x CD cord-010092-uftc8inx 12355 6 , , , cord-010092-uftc8inx 12355 7 HBV HBV NNP cord-010092-uftc8inx 12355 8 2x 2x CD cord-010092-uftc8inx 12355 9 , , , cord-010092-uftc8inx 12355 10 HCV HCV NNP cord-010092-uftc8inx 12355 11 1x 1x CD cord-010092-uftc8inx 12355 12 ) ) -RRB- cord-010092-uftc8inx 12356 1 Platelets platelet NNS cord-010092-uftc8inx 12356 2 : : : cord-010092-uftc8inx 12356 3 88,438 88,438 CD cord-010092-uftc8inx 12356 4 thrombocyte thrombocyte NNP cord-010092-uftc8inx 12356 5 administrations administration NNS cord-010092-uftc8inx 12356 6 , , , cord-010092-uftc8inx 12356 7 including include VBG cord-010092-uftc8inx 12356 8 178 178 CD cord-010092-uftc8inx 12356 9 transfusion transfusion NN cord-010092-uftc8inx 12356 10 reactions reaction NNS cord-010092-uftc8inx 12356 11 ( ( -LRB- cord-010092-uftc8inx 12356 12 Allergy Allergy NNP cord-010092-uftc8inx 12356 13 129x 129x NNP cord-010092-uftc8inx 12356 14 , , , cord-010092-uftc8inx 12356 15 FNHTR FNHTR NNP cord-010092-uftc8inx 12356 16 30x 30x NNS cord-010092-uftc8inx 12356 17 , , , cord-010092-uftc8inx 12356 18 Anaphylaxis anaphylaxis NN cord-010092-uftc8inx 12356 19 5x 5x CD cord-010092-uftc8inx 12356 20 , , , cord-010092-uftc8inx 12356 21 Circulatory circulatory JJ cord-010092-uftc8inx 12356 22 overload overload NN cord-010092-uftc8inx 12356 23 8x 8x CD cord-010092-uftc8inx 12356 24 , , , cord-010092-uftc8inx 12356 25 Delayed delay VBN cord-010092-uftc8inx 12356 26 immune immune JJ cord-010092-uftc8inx 12356 27 hemolysis hemolysis NN cord-010092-uftc8inx 12356 28 3x 3x CD cord-010092-uftc8inx 12356 29 , , , cord-010092-uftc8inx 12356 30 Acute acute JJ cord-010092-uftc8inx 12356 31 circulatory circulatory JJ cord-010092-uftc8inx 12356 32 overload overload NN cord-010092-uftc8inx 12356 33 8x 8x CD cord-010092-uftc8inx 12356 34 . . . cord-010092-uftc8inx 12357 1 Granulocytes granulocyte NNS cord-010092-uftc8inx 12357 2 : : : cord-010092-uftc8inx 12357 3 203 203 CD cord-010092-uftc8inx 12357 4 administrations administration NNS cord-010092-uftc8inx 12357 5 , , , cord-010092-uftc8inx 12357 6 2 2 CD cord-010092-uftc8inx 12357 7 transfusion transfusion NN cord-010092-uftc8inx 12357 8 reactions reaction NNS cord-010092-uftc8inx 12357 9 Plasma Plasma NNP cord-010092-uftc8inx 12357 10 : : : cord-010092-uftc8inx 12357 11 293,801 293,801 CD cord-010092-uftc8inx 12357 12 administrations administration NNS cord-010092-uftc8inx 12357 13 , , , cord-010092-uftc8inx 12357 14 359 359 CD cord-010092-uftc8inx 12357 15 reactions reaction NNS cord-010092-uftc8inx 12357 16 reported report VBN cord-010092-uftc8inx 12357 17 ( ( -LRB- cord-010092-uftc8inx 12357 18 allergy allergy NN cord-010092-uftc8inx 12357 19 278 278 CD cord-010092-uftc8inx 12357 20 , , , cord-010092-uftc8inx 12357 21 FNHR FNHR NNP cord-010092-uftc8inx 12357 22 25 25 CD cord-010092-uftc8inx 12357 23 , , , cord-010092-uftc8inx 12357 24 circulatory circulatory JJ cord-010092-uftc8inx 12357 25 overload overload NN cord-010092-uftc8inx 12357 26 14 14 CD cord-010092-uftc8inx 12357 27 , , , cord-010092-uftc8inx 12357 28 anaphylaxis anaphylaxis NN cord-010092-uftc8inx 12357 29 17x 17x NNS cord-010092-uftc8inx 12357 30 , , , cord-010092-uftc8inx 12357 31 TRALI TRALI NNP cord-010092-uftc8inx 12357 32 4x 4x CD cord-010092-uftc8inx 12357 33 , , , cord-010092-uftc8inx 12357 34 HBV HBV NNP cord-010092-uftc8inx 12357 35 3x 3x CD cord-010092-uftc8inx 12357 36 , , , cord-010092-uftc8inx 12357 37 ARDS ARDS NNP cord-010092-uftc8inx 12357 38 1x 1x CD cord-010092-uftc8inx 12357 39 . . . cord-010092-uftc8inx 12358 1 Summary Summary NNP cord-010092-uftc8inx 12358 2 / / SYM cord-010092-uftc8inx 12358 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 12358 4 : : : cord-010092-uftc8inx 12359 1 Conclusions conclusion NNS cord-010092-uftc8inx 12359 2 : : : cord-010092-uftc8inx 12360 1 Comprehensive comprehensive JJ cord-010092-uftc8inx 12360 2 analysis analysis NN cord-010092-uftc8inx 12360 3 and and CC cord-010092-uftc8inx 12360 4 data data NN cord-010092-uftc8inx 12360 5 processing processing NN cord-010092-uftc8inx 12360 6 help help NN cord-010092-uftc8inx 12360 7 to to TO cord-010092-uftc8inx 12360 8 appropriate appropriate VB cord-010092-uftc8inx 12360 9 prospective prospective JJ cord-010092-uftc8inx 12360 10 setting setting NN cord-010092-uftc8inx 12360 11 of of IN cord-010092-uftc8inx 12360 12 blood blood NN cord-010092-uftc8inx 12360 13 products product NNS cord-010092-uftc8inx 12360 14 ( ( -LRB- cord-010092-uftc8inx 12360 15 BP BP NNP cord-010092-uftc8inx 12360 16 ) ) -RRB- cord-010092-uftc8inx 12360 17 production production NN cord-010092-uftc8inx 12360 18 and and CC cord-010092-uftc8inx 12360 19 hemotherapy hemotherapy NN cord-010092-uftc8inx 12360 20 . . . cord-010092-uftc8inx 12361 1 Concrete concrete JJ cord-010092-uftc8inx 12361 2 outputs output NNS cord-010092-uftc8inx 12361 3 from from IN cord-010092-uftc8inx 12361 4 processed process VBN cord-010092-uftc8inx 12361 5 data datum NNS cord-010092-uftc8inx 12361 6 triggered trigger VBD cord-010092-uftc8inx 12361 7 undermentioned undermentioned JJ cord-010092-uftc8inx 12361 8 changes change NNS cord-010092-uftc8inx 12361 9 in in IN cord-010092-uftc8inx 12361 10 many many JJ cord-010092-uftc8inx 12361 11 departments department NNS cord-010092-uftc8inx 12361 12 in in IN cord-010092-uftc8inx 12361 13 the the DT cord-010092-uftc8inx 12361 14 CR cr NN cord-010092-uftc8inx 12361 15 : : : cord-010092-uftc8inx 12361 16 1 1 CD cord-010092-uftc8inx 12361 17 . . . cord-010092-uftc8inx 12361 18 plasma plasma NN cord-010092-uftc8inx 12361 19 for for IN cord-010092-uftc8inx 12361 20 clinical clinical JJ cord-010092-uftc8inx 12361 21 uses use NNS cord-010092-uftc8inx 12361 22 from from IN cord-010092-uftc8inx 12361 23 male male JJ cord-010092-uftc8inx 12361 24 blood blood NN cord-010092-uftc8inx 12361 25 donors donor NNS cord-010092-uftc8inx 12361 26 , , , cord-010092-uftc8inx 12361 27 2 2 CD cord-010092-uftc8inx 12361 28 . . . cord-010092-uftc8inx 12362 1 prestorage prestorage NNP cord-010092-uftc8inx 12362 2 of of IN cord-010092-uftc8inx 12362 3 leucocyte leucocyte NNP cord-010092-uftc8inx 12362 4 reduced reduce VBN cord-010092-uftc8inx 12362 5 blood blood NN cord-010092-uftc8inx 12362 6 products product NNS cord-010092-uftc8inx 12362 7 , , , cord-010092-uftc8inx 12362 8 3 3 CD cord-010092-uftc8inx 12362 9 . . . cord-010092-uftc8inx 12363 1 production production NN cord-010092-uftc8inx 12363 2 of of IN cord-010092-uftc8inx 12363 3 platelets platelet NNS cord-010092-uftc8inx 12363 4 in in IN cord-010092-uftc8inx 12363 5 additive additive NN cord-010092-uftc8inx 12363 6 solutions solution NNS cord-010092-uftc8inx 12363 7 , , , cord-010092-uftc8inx 12363 8 4 4 CD cord-010092-uftc8inx 12363 9 . . . cord-010092-uftc8inx 12364 1 implementation implementation NN cord-010092-uftc8inx 12364 2 of of IN cord-010092-uftc8inx 12364 3 PCR PCR NNP cord-010092-uftc8inx 12364 4 testing testing NN cord-010092-uftc8inx 12364 5 method method NN cord-010092-uftc8inx 12364 6 for for IN cord-010092-uftc8inx 12364 7 blood blood NN cord-010092-uftc8inx 12364 8 donors donor NNS cord-010092-uftc8inx 12364 9 screening screen VBG cord-010092-uftc8inx 12364 10 . . . cord-010092-uftc8inx 12365 1 Background background NN cord-010092-uftc8inx 12365 2 : : : cord-010092-uftc8inx 12366 1 SKAE SKAE NNP cord-010092-uftc8inx 12366 2 's 's POS cord-010092-uftc8inx 12366 3 basic basic JJ cord-010092-uftc8inx 12366 4 activities activity NNS cord-010092-uftc8inx 12366 5 include include VBP cord-010092-uftc8inx 12366 6 epidemiological epidemiological JJ cord-010092-uftc8inx 12366 7 surveillance surveillance NN cord-010092-uftc8inx 12366 8 of of IN cord-010092-uftc8inx 12366 9 all all DT cord-010092-uftc8inx 12366 10 adverse adverse JJ cord-010092-uftc8inx 12366 11 events event NNS cord-010092-uftc8inx 12366 12 ( ( -LRB- cord-010092-uftc8inx 12366 13 AEs AEs NNP cord-010092-uftc8inx 12366 14 ) ) -RRB- cord-010092-uftc8inx 12366 15 associated associate VBN cord-010092-uftc8inx 12366 16 with with IN cord-010092-uftc8inx 12366 17 deviations deviation NNS cord-010092-uftc8inx 12366 18 in in IN cord-010092-uftc8inx 12366 19 the the DT cord-010092-uftc8inx 12366 20 collecting collecting NN cord-010092-uftc8inx 12366 21 , , , cord-010092-uftc8inx 12366 22 testing testing NN cord-010092-uftc8inx 12366 23 , , , cord-010092-uftc8inx 12366 24 processing processing NN cord-010092-uftc8inx 12366 25 , , , cord-010092-uftc8inx 12366 26 storage storage NN cord-010092-uftc8inx 12366 27 and and CC cord-010092-uftc8inx 12366 28 distribution distribution NN cord-010092-uftc8inx 12366 29 of of IN cord-010092-uftc8inx 12366 30 blood blood NN cord-010092-uftc8inx 12366 31 and and CC cord-010092-uftc8inx 12366 32 blood blood NN cord-010092-uftc8inx 12366 33 components component NNS cord-010092-uftc8inx 12366 34 that that WDT cord-010092-uftc8inx 12366 35 may may MD cord-010092-uftc8inx 12366 36 affect affect VB cord-010092-uftc8inx 12366 37 quality quality NN cord-010092-uftc8inx 12366 38 and and CC cord-010092-uftc8inx 12366 39 safety safety NN cord-010092-uftc8inx 12366 40 Near near IN cord-010092-uftc8inx 12366 41 misses miss VBZ cord-010092-uftc8inx 12366 42 " " '' cord-010092-uftc8inx 12366 43 and and CC cord-010092-uftc8inx 12366 44 " " `` cord-010092-uftc8inx 12366 45 uneventful uneventful JJ cord-010092-uftc8inx 12366 46 transfusion transfusion NN cord-010092-uftc8inx 12366 47 errors error NNS cord-010092-uftc8inx 12366 48 " " '' cord-010092-uftc8inx 12366 49 are be VBP cord-010092-uftc8inx 12366 50 collected collect VBN cord-010092-uftc8inx 12366 51 to to TO cord-010092-uftc8inx 12366 52 identify identify VB cord-010092-uftc8inx 12366 53 preventable preventable JJ cord-010092-uftc8inx 12366 54 causes cause NNS cord-010092-uftc8inx 12366 55 . . . cord-010092-uftc8inx 12367 1 Incorrect incorrect JJ cord-010092-uftc8inx 12367 2 Blood blood NN cord-010092-uftc8inx 12367 3 Component component NN cord-010092-uftc8inx 12367 4 Transfused transfuse VBN cord-010092-uftc8inx 12367 5 ( ( -LRB- cord-010092-uftc8inx 12367 6 IBCT IBCT NNP cord-010092-uftc8inx 12367 7 ) ) -RRB- cord-010092-uftc8inx 12367 8 events event NNS cord-010092-uftc8inx 12367 9 are be VBP cord-010092-uftc8inx 12367 10 reported report VBN cord-010092-uftc8inx 12367 11 following follow VBG cord-010092-uftc8inx 12367 12 IHN ihn NN cord-010092-uftc8inx 12367 13 instructions instruction NNS cord-010092-uftc8inx 12367 14 . . . cord-010092-uftc8inx 12368 1 Results result NNS cord-010092-uftc8inx 12368 2 : : : cord-010092-uftc8inx 12369 1 A a DT cord-010092-uftc8inx 12369 2 total total NN cord-010092-uftc8inx 12369 3 of of IN cord-010092-uftc8inx 12369 4 5 5 CD cord-010092-uftc8inx 12369 5 They -PRON- PRP cord-010092-uftc8inx 12369 6 were be VBD cord-010092-uftc8inx 12369 7 mainly mainly RB cord-010092-uftc8inx 12369 8 associated associate VBN cord-010092-uftc8inx 12369 9 with with IN cord-010092-uftc8inx 12369 10 deviation deviation NN cord-010092-uftc8inx 12369 11 in in IN cord-010092-uftc8inx 12369 12 Processing processing NN cord-010092-uftc8inx 12369 13 ( ( -LRB- cord-010092-uftc8inx 12369 14 22.4 22.4 CD cord-010092-uftc8inx 12369 15 % % NN cord-010092-uftc8inx 12369 16 ) ) -RRB- cord-010092-uftc8inx 12369 17 and and CC cord-010092-uftc8inx 12369 18 attributed attribute VBN cord-010092-uftc8inx 12369 19 to to IN cord-010092-uftc8inx 12369 20 Equipment equipment NN cord-010092-uftc8inx 12369 21 failure failure NN cord-010092-uftc8inx 12369 22 and and CC cord-010092-uftc8inx 12369 23 Materials material NNS cord-010092-uftc8inx 12369 24 ( ( -LRB- cord-010092-uftc8inx 12369 25 71 71 CD cord-010092-uftc8inx 12369 26 % % NN cord-010092-uftc8inx 12369 27 ) ) -RRB- cord-010092-uftc8inx 12370 1 Whole whole JJ cord-010092-uftc8inx 12370 2 Blood Blood NNP cord-010092-uftc8inx 12370 3 Collection Collection NNP cord-010092-uftc8inx 12370 4 , , , cord-010092-uftc8inx 12370 5 Materials Materials NNPS cord-010092-uftc8inx 12370 6 and and CC cord-010092-uftc8inx 12370 7 Distribution Distribution NNP cord-010092-uftc8inx 12370 8 , , , cord-010092-uftc8inx 12370 9 as as IN cord-010092-uftc8inx 12370 10 a a DT cord-010092-uftc8inx 12370 11 result result NN cord-010092-uftc8inx 12370 12 of of IN cord-010092-uftc8inx 12370 13 Product Product NNP cord-010092-uftc8inx 12370 14 Defect Defect NNP cord-010092-uftc8inx 12370 15 , , , cord-010092-uftc8inx 12370 16 Equipment Equipment NNP cord-010092-uftc8inx 12370 17 Failure failure NN cord-010092-uftc8inx 12370 18 , , , cord-010092-uftc8inx 12370 19 Human Human NNP cord-010092-uftc8inx 12370 20 Error Error NNP cord-010092-uftc8inx 12370 21 and and CC cord-010092-uftc8inx 12370 22 Other Other NNP cord-010092-uftc8inx 12370 23 . . . cord-010092-uftc8inx 12371 1 Trend trend NN cord-010092-uftc8inx 12371 2 analysis analysis NN cord-010092-uftc8inx 12371 3 showed show VBD cord-010092-uftc8inx 12371 4 a a DT cord-010092-uftc8inx 12371 5 significantly significantly RB cord-010092-uftc8inx 12371 6 increasing increase VBG cord-010092-uftc8inx 12371 7 ( ( -LRB- cord-010092-uftc8inx 12371 8 P p NN cord-010092-uftc8inx 12371 9 < < XX cord-010092-uftc8inx 12371 10 .001 .001 CD cord-010092-uftc8inx 12371 11 ) ) -RRB- cord-010092-uftc8inx 12371 12 annual annual JJ cord-010092-uftc8inx 12371 13 rate rate NN cord-010092-uftc8inx 12371 14 of of IN cord-010092-uftc8inx 12371 15 total total JJ cord-010092-uftc8inx 12371 16 AEs ae NNS cord-010092-uftc8inx 12371 17 by by IN cord-010092-uftc8inx 12371 18 28 28 CD cord-010092-uftc8inx 12371 19 % % NN cord-010092-uftc8inx 12371 20 ( ( -LRB- cord-010092-uftc8inx 12371 21 95 95 CD cord-010092-uftc8inx 12371 22 % % NN cord-010092-uftc8inx 12371 23 confidence confidence NN cord-010092-uftc8inx 12371 24 interval interval NN cord-010092-uftc8inx 12371 25 26 26 CD cord-010092-uftc8inx 12371 26 - - SYM cord-010092-uftc8inx 12371 27 30 30 CD cord-010092-uftc8inx 12371 28 ) ) -RRB- cord-010092-uftc8inx 12371 29 ) ) -RRB- cord-010092-uftc8inx 12372 1 10 10 CD cord-010092-uftc8inx 12372 2 % % NN cord-010092-uftc8inx 12373 1 fibrinogen fibrinogen NN cord-010092-uftc8inx 12373 2 - - HYPH cord-010092-uftc8inx 12373 3 depleted deplete VBN cord-010092-uftc8inx 12374 1 pHPL pHPL NNP cord-010092-uftc8inx 12374 2 or or CC cord-010092-uftc8inx 12374 3 ( ( -LRB- cord-010092-uftc8inx 12374 4 3 3 CD cord-010092-uftc8inx 12374 5 ) ) -RRB- cord-010092-uftc8inx 12374 6 10 10 CD cord-010092-uftc8inx 12374 7 % % NN cord-010092-uftc8inx 12375 1 fibrinogen fibrinogen NN cord-010092-uftc8inx 12375 2 - - HYPH cord-010092-uftc8inx 12375 3 depleted deplete VBN cord-010092-uftc8inx 12375 4 pHPL phpl JJ cord-010092-uftc8inx 12375 5 plus plus CC cord-010092-uftc8inx 12375 6 heparin heparin NN cord-010092-uftc8inx 12375 7 . . . cord-010092-uftc8inx 12376 1 Internalization internalization NN cord-010092-uftc8inx 12376 2 of of IN cord-010092-uftc8inx 12376 3 fluoresceinamine fluoresceinamine NN cord-010092-uftc8inx 12376 4 - - HYPH cord-010092-uftc8inx 12376 5 labeled label VBN cord-010092-uftc8inx 12376 6 heparin heparin NN cord-010092-uftc8inx 12376 7 in in IN cord-010092-uftc8inx 12376 8 STCs stc NNS cord-010092-uftc8inx 12376 9 was be VBD cord-010092-uftc8inx 12376 10 investigated investigate VBN cord-010092-uftc8inx 12376 11 by by IN cord-010092-uftc8inx 12376 12 flow flow NN cord-010092-uftc8inx 12376 13 cytometry cytometry NN cord-010092-uftc8inx 12376 14 and and CC cord-010092-uftc8inx 12376 15 immunocytochemistry immunocytochemistry NN cord-010092-uftc8inx 12376 16 . . . cord-010092-uftc8inx 12377 1 All all DT cord-010092-uftc8inx 12377 2 stromal stromal JJ cord-010092-uftc8inx 12377 3 cells cell NNS cord-010092-uftc8inx 12377 4 were be VBD cord-010092-uftc8inx 12377 5 subjected subject VBN cord-010092-uftc8inx 12377 6 to to IN cord-010092-uftc8inx 12377 7 whole whole JJ cord-010092-uftc8inx 12377 8 genome genome NN cord-010092-uftc8inx 12377 9 expression expression NN cord-010092-uftc8inx 12377 10 analysis analysis NN cord-010092-uftc8inx 12377 11 ( ( -LRB- cord-010092-uftc8inx 12377 12 Affymetrix Affymetrix NNP cord-010092-uftc8inx 12377 13 Human Human NNP cord-010092-uftc8inx 12377 14 Gene Gene NNP cord-010092-uftc8inx 12377 15 2.1 2.1 CD cord-010092-uftc8inx 12377 16 ST ST NNP cord-010092-uftc8inx 12377 17 array array NN cord-010092-uftc8inx 12377 18 ) ) -RRB- cord-010092-uftc8inx 12377 19 and and CC cord-010092-uftc8inx 12377 20 data datum NNS cord-010092-uftc8inx 12377 21 were be VBD cord-010092-uftc8inx 12377 22 analyzed analyze VBN cord-010092-uftc8inx 12377 23 using use VBG cord-010092-uftc8inx 12377 24 R R NNP cord-010092-uftc8inx 12377 25 / / SYM cord-010092-uftc8inx 12377 26 Bioconductor Bioconductor NNP cord-010092-uftc8inx 12377 27 and and CC cord-010092-uftc8inx 12377 28 Panther Panther NNP cord-010092-uftc8inx 12377 29 analysis analysis NN cord-010092-uftc8inx 12377 30 tools tool NNS cord-010092-uftc8inx 12377 31 . . . cord-010092-uftc8inx 12378 1 Confirmative Confirmative NNP cord-010092-uftc8inx 12378 2 qRT qRT NNP cord-010092-uftc8inx 12378 3 - - HYPH cord-010092-uftc8inx 12378 4 PCR PCR NNP cord-010092-uftc8inx 12378 5 was be VBD cord-010092-uftc8inx 12378 6 performed perform VBN cord-010092-uftc8inx 12378 7 and and CC cord-010092-uftc8inx 12378 8 protein protein NN cord-010092-uftc8inx 12378 9 levels level NNS cord-010092-uftc8inx 12378 10 of of IN cord-010092-uftc8inx 12378 11 selected select VBN cord-010092-uftc8inx 12378 12 pathways pathway NNS cord-010092-uftc8inx 12378 13 were be VBD cord-010092-uftc8inx 12378 14 analyzed analyze VBN cord-010092-uftc8inx 12378 15 by by IN cord-010092-uftc8inx 12378 16 a a DT cord-010092-uftc8inx 12378 17 bead bead NN cord-010092-uftc8inx 12378 18 - - HYPH cord-010092-uftc8inx 12378 19 based base VBN cord-010092-uftc8inx 12378 20 western western JJ cord-010092-uftc8inx 12378 21 blot blot NN cord-010092-uftc8inx 12378 22 system system NN cord-010092-uftc8inx 12378 23 ( ( -LRB- cord-010092-uftc8inx 12378 24 DigiWest DigiWest NNP cord-010092-uftc8inx 12378 25 â â NN cord-010092-uftc8inx 12378 26 ) ) -RRB- cord-010092-uftc8inx 12378 27 . . . cord-010092-uftc8inx 12379 1 Immunophenotyping immunophenotyping NN cord-010092-uftc8inx 12379 2 , , , cord-010092-uftc8inx 12379 3 in in IN cord-010092-uftc8inx 12379 4 vitro vitro FW cord-010092-uftc8inx 12379 5 differentiation differentiation NN cord-010092-uftc8inx 12379 6 , , , cord-010092-uftc8inx 12379 7 longterm longterm JJ cord-010092-uftc8inx 12379 8 proliferation proliferation NN cord-010092-uftc8inx 12379 9 and and CC cord-010092-uftc8inx 12379 10 colony colony NN cord-010092-uftc8inx 12379 11 forming form VBG cord-010092-uftc8inx 12379 12 units unit NNS cord-010092-uftc8inx 12379 13 ( ( -LRB- cord-010092-uftc8inx 12379 14 CFU CFU NNP cord-010092-uftc8inx 12379 15 ) ) -RRB- cord-010092-uftc8inx 12379 16 assays assay NNS cord-010092-uftc8inx 12379 17 were be VBD cord-010092-uftc8inx 12379 18 done do VBN cord-010092-uftc8inx 12379 19 for for IN cord-010092-uftc8inx 12379 20 all all DT cord-010092-uftc8inx 12379 21 cell cell NN cord-010092-uftc8inx 12379 22 types type NNS cord-010092-uftc8inx 12379 23 . . . cord-010092-uftc8inx 12380 1 Results result NNS cord-010092-uftc8inx 12380 2 : : : cord-010092-uftc8inx 12381 1 In in IN cord-010092-uftc8inx 12381 2 vitro vitro FW cord-010092-uftc8inx 12381 3 exposure exposure NN cord-010092-uftc8inx 12381 4 of of IN cord-010092-uftc8inx 12381 5 heparin heparin NN cord-010092-uftc8inx 12381 6 induced induce VBN cord-010092-uftc8inx 12381 7 differential differential JJ cord-010092-uftc8inx 12381 8 internalization internalization NN cord-010092-uftc8inx 12381 9 and and CC cord-010092-uftc8inx 12381 10 lysosomal lysosomal JJ cord-010092-uftc8inx 12381 11 accumulation accumulation NN cord-010092-uftc8inx 12381 12 in in IN cord-010092-uftc8inx 12381 13 stromal stromal JJ cord-010092-uftc8inx 12381 14 cells cell NNS cord-010092-uftc8inx 12381 15 , , , cord-010092-uftc8inx 12381 16 as as RB cord-010092-uftc8inx 12381 17 well well RB cord-010092-uftc8inx 12381 18 as as IN cord-010092-uftc8inx 12381 19 regulation regulation NN cord-010092-uftc8inx 12381 20 of of IN cord-010092-uftc8inx 12381 21 distinct distinct JJ cord-010092-uftc8inx 12381 22 gene gene NN cord-010092-uftc8inx 12381 23 sets set NNS cord-010092-uftc8inx 12381 24 , , , cord-010092-uftc8inx 12381 25 both both CC cord-010092-uftc8inx 12381 26 in in IN cord-010092-uftc8inx 12381 27 a a DT cord-010092-uftc8inx 12381 28 tissue tissue NN cord-010092-uftc8inx 12381 29 - - HYPH cord-010092-uftc8inx 12381 30 source source NN cord-010092-uftc8inx 12381 31 dependent dependent JJ cord-010092-uftc8inx 12381 32 manner manner NN cord-010092-uftc8inx 12381 33 . . . cord-010092-uftc8inx 12382 1 Affected affect VBN cord-010092-uftc8inx 12382 2 signaling signal VBG cord-010092-uftc8inx 12382 3 cascades cascade NNS cord-010092-uftc8inx 12382 4 were be VBD cord-010092-uftc8inx 12382 5 mainly mainly RB cord-010092-uftc8inx 12382 6 involved involve VBN cord-010092-uftc8inx 12382 7 in in IN cord-010092-uftc8inx 12382 8 proliferation proliferation NN cord-010092-uftc8inx 12382 9 , , , cord-010092-uftc8inx 12382 10 cell cell NN cord-010092-uftc8inx 12382 11 adhesion adhesion NN cord-010092-uftc8inx 12382 12 , , , cord-010092-uftc8inx 12382 13 apoptosis apoptosis NN cord-010092-uftc8inx 12382 14 , , , cord-010092-uftc8inx 12382 15 inflammation inflammation NN cord-010092-uftc8inx 12382 16 and and CC cord-010092-uftc8inx 12382 17 angiogenesis angiogenesis NN cord-010092-uftc8inx 12382 18 . . . cord-010092-uftc8inx 12383 1 The the DT cord-010092-uftc8inx 12383 2 influence influence NN cord-010092-uftc8inx 12383 3 of of IN cord-010092-uftc8inx 12383 4 heparin heparin NN cord-010092-uftc8inx 12383 5 on on IN cord-010092-uftc8inx 12383 6 protein protein NN cord-010092-uftc8inx 12383 7 expression expression NN cord-010092-uftc8inx 12383 8 and and CC cord-010092-uftc8inx 12383 9 phosphorylation phosphorylation NN cord-010092-uftc8inx 12383 10 of of IN cord-010092-uftc8inx 12383 11 four four CD cord-010092-uftc8inx 12383 12 pathways pathway NNS cord-010092-uftc8inx 12383 13 ( ( -LRB- cord-010092-uftc8inx 12383 14 WNT WNT NNP cord-010092-uftc8inx 12383 15 , , , cord-010092-uftc8inx 12383 16 PDGF PDGF NNP cord-010092-uftc8inx 12383 17 , , , cord-010092-uftc8inx 12383 18 NOTCH notch NN cord-010092-uftc8inx 12383 19 and and CC cord-010092-uftc8inx 12383 20 TGFbeta TGFbeta NNP cord-010092-uftc8inx 12383 21 ) ) -RRB- cord-010092-uftc8inx 12383 22 was be VBD cord-010092-uftc8inx 12383 23 further further RB cord-010092-uftc8inx 12383 24 analyzed analyze VBN cord-010092-uftc8inx 12383 25 , , , cord-010092-uftc8inx 12383 26 revealing reveal VBG cord-010092-uftc8inx 12383 27 most most JJS cord-010092-uftc8inx 12383 28 alterations alteration NNS cord-010092-uftc8inx 12383 29 in in IN cord-010092-uftc8inx 12383 30 BM BM NNP cord-010092-uftc8inx 12383 31 - - HYPH cord-010092-uftc8inx 12383 32 STCs stc NNS cord-010092-uftc8inx 12383 33 . . . cord-010092-uftc8inx 12384 1 Independent independent JJ cord-010092-uftc8inx 12384 2 of of IN cord-010092-uftc8inx 12384 3 origin origin NN cord-010092-uftc8inx 12384 4 and and CC cord-010092-uftc8inx 12384 5 medium medium JJ cord-010092-uftc8inx 12384 6 composition composition NN cord-010092-uftc8inx 12384 7 , , , cord-010092-uftc8inx 12384 8 flow flow NN cord-010092-uftc8inx 12384 9 cytometry cytometry NN cord-010092-uftc8inx 12384 10 analysis analysis NN cord-010092-uftc8inx 12384 11 revealed reveal VBD cord-010092-uftc8inx 12384 12 the the DT cord-010092-uftc8inx 12384 13 characteristic characteristic JJ cord-010092-uftc8inx 12384 14 fibroblastoid fibroblastoid JJ cord-010092-uftc8inx 12384 15 phenotype phenotype NN cord-010092-uftc8inx 12384 16 profile profile NN cord-010092-uftc8inx 12384 17 ( ( -LRB- cord-010092-uftc8inx 12384 18 CD73+/90+/105 CD73+/90+/105 NNP cord-010092-uftc8inx 12384 19 + + CC cord-010092-uftc8inx 12384 20 and and CC cord-010092-uftc8inx 12384 21 CD14-/19-/34-/45-/HLA CD14-/19-/34-/45-/HLA NNP cord-010092-uftc8inx 12384 22 - - HYPH cord-010092-uftc8inx 12384 23 DR- DR- NNP cord-010092-uftc8inx 12384 24 ) ) -RRB- cord-010092-uftc8inx 12384 25 . . . cord-010092-uftc8inx 12385 1 In in IN cord-010092-uftc8inx 12385 2 addition addition NN cord-010092-uftc8inx 12385 3 a a DT cord-010092-uftc8inx 12385 4 comparable comparable JJ cord-010092-uftc8inx 12385 5 osteogenic osteogenic JJ cord-010092-uftc8inx 12385 6 and and CC cord-010092-uftc8inx 12385 7 adipogenic adipogenic JJ cord-010092-uftc8inx 12385 8 differentiation differentiation NN cord-010092-uftc8inx 12385 9 capacity capacity NN cord-010092-uftc8inx 12385 10 was be VBD cord-010092-uftc8inx 12385 11 found find VBN cord-010092-uftc8inx 12385 12 Summary Summary NNP cord-010092-uftc8inx 12385 13 / / SYM cord-010092-uftc8inx 12385 14 Conclusions Conclusions NNPS cord-010092-uftc8inx 12385 15 : : : cord-010092-uftc8inx 12386 1 Internalization internalization NN cord-010092-uftc8inx 12386 2 of of IN cord-010092-uftc8inx 12386 3 heparin heparin NN cord-010092-uftc8inx 12386 4 in in IN cord-010092-uftc8inx 12386 5 lysosomes lysosome NNS cord-010092-uftc8inx 12386 6 by by IN cord-010092-uftc8inx 12386 7 stromal stromal JJ cord-010092-uftc8inx 12386 8 cells cell NNS cord-010092-uftc8inx 12386 9 , , , cord-010092-uftc8inx 12386 10 differential differential JJ cord-010092-uftc8inx 12386 11 gene gene NN cord-010092-uftc8inx 12386 12 and and CC cord-010092-uftc8inx 12386 13 protein protein NN cord-010092-uftc8inx 12386 14 expression expression NN cord-010092-uftc8inx 12386 15 and and CC cord-010092-uftc8inx 12386 16 phosphorylation phosphorylation NN cord-010092-uftc8inx 12386 17 changes change NNS cord-010092-uftc8inx 12386 18 were be VBD cord-010092-uftc8inx 12386 19 observed observe VBN cord-010092-uftc8inx 12386 20 in in IN cord-010092-uftc8inx 12386 21 a a DT cord-010092-uftc8inx 12386 22 tissue tissue NN cord-010092-uftc8inx 12386 23 - - HYPH cord-010092-uftc8inx 12386 24 source source NN cord-010092-uftc8inx 12386 25 dependent dependent JJ cord-010092-uftc8inx 12386 26 manner manner NN cord-010092-uftc8inx 12386 27 . . . cord-010092-uftc8inx 12387 1 However however RB cord-010092-uftc8inx 12387 2 , , , cord-010092-uftc8inx 12387 3 stromal stromal JJ cord-010092-uftc8inx 12387 4 cell cell NN cord-010092-uftc8inx 12387 5 characteristics characteristic NNS cord-010092-uftc8inx 12387 6 as as IN cord-010092-uftc8inx 12387 7 immunophenotype immunophenotype NN cord-010092-uftc8inx 12387 8 pattern pattern NN cord-010092-uftc8inx 12387 9 , , , cord-010092-uftc8inx 12387 10 long long JJ cord-010092-uftc8inx 12387 11 - - HYPH cord-010092-uftc8inx 12387 12 term term NN cord-010092-uftc8inx 12387 13 proliferation proliferation NN cord-010092-uftc8inx 12387 14 , , , cord-010092-uftc8inx 12387 15 clonogenicity clonogenicity NN cord-010092-uftc8inx 12387 16 and and CC cord-010092-uftc8inx 12387 17 in in IN cord-010092-uftc8inx 12387 18 vitro vitro FW cord-010092-uftc8inx 12387 19 differentiation differentiation NN cord-010092-uftc8inx 12387 20 were be VBD cord-010092-uftc8inx 12387 21 unaffected unaffected JJ cord-010092-uftc8inx 12387 22 , , , cord-010092-uftc8inx 12387 23 putatively putatively RB cord-010092-uftc8inx 12387 24 by by IN cord-010092-uftc8inx 12387 25 post post JJ cord-010092-uftc8inx 12387 26 - - JJ cord-010092-uftc8inx 12387 27 translational translational JJ cord-010092-uftc8inx 12387 28 protein protein NN cord-010092-uftc8inx 12387 29 modifications modification NNS cord-010092-uftc8inx 12387 30 . . . cord-010092-uftc8inx 12388 1 In in IN cord-010092-uftc8inx 12388 2 this this DT cord-010092-uftc8inx 12388 3 respect respect NN cord-010092-uftc8inx 12388 4 , , , cord-010092-uftc8inx 12388 5 application application NN cord-010092-uftc8inx 12388 6 of of IN cord-010092-uftc8inx 12388 7 porcine porcine JJ cord-010092-uftc8inx 12388 8 heparin heparin NN cord-010092-uftc8inx 12388 9 is be VBZ cord-010092-uftc8inx 12388 10 compatible compatible JJ cord-010092-uftc8inx 12388 11 with with IN cord-010092-uftc8inx 12388 12 efficient efficient JJ cord-010092-uftc8inx 12388 13 manufacturing manufacturing NN cord-010092-uftc8inx 12388 14 of of IN cord-010092-uftc8inx 12388 15 stromal stromal JJ cord-010092-uftc8inx 12388 16 cell cell NN cord-010092-uftc8inx 12388 17 based base VBN cord-010092-uftc8inx 12388 18 medicinal medicinal JJ cord-010092-uftc8inx 12388 19 products product NNS cord-010092-uftc8inx 12388 20 ABO ABO NNP cord-010092-uftc8inx 12388 21 incompatibility incompatibility NN cord-010092-uftc8inx 12388 22 may may MD cord-010092-uftc8inx 12388 23 have have VB cord-010092-uftc8inx 12388 24 no no DT cord-010092-uftc8inx 12388 25 effect effect NN cord-010092-uftc8inx 12388 26 on on IN cord-010092-uftc8inx 12388 27 the the DT cord-010092-uftc8inx 12388 28 clinical clinical JJ cord-010092-uftc8inx 12388 29 outcome outcome NN cord-010092-uftc8inx 12388 30 after after IN cord-010092-uftc8inx 12388 31 allogeneic allogeneic JJ cord-010092-uftc8inx 12388 32 hematopoietic hematopoietic JJ cord-010092-uftc8inx 12388 33 stem stem NN cord-010092-uftc8inx 12388 34 cell cell NN cord-010092-uftc8inx 12388 35 transplantation transplantation NN cord-010092-uftc8inx 12388 36 . . . cord-010092-uftc8inx 12389 1 However however RB cord-010092-uftc8inx 12389 2 , , , cord-010092-uftc8inx 12389 3 it -PRON- PRP cord-010092-uftc8inx 12389 4 carries carry VBZ cord-010092-uftc8inx 12389 5 additional additional JJ cord-010092-uftc8inx 12389 6 risks risk NNS cord-010092-uftc8inx 12389 7 of of IN cord-010092-uftc8inx 12389 8 hemolytic hemolytic JJ cord-010092-uftc8inx 12389 9 reactions reaction NNS cord-010092-uftc8inx 12389 10 , , , cord-010092-uftc8inx 12389 11 delayed delay VBD cord-010092-uftc8inx 12389 12 red red JJ cord-010092-uftc8inx 12389 13 blood blood NN cord-010092-uftc8inx 12389 14 cell cell NN cord-010092-uftc8inx 12389 15 ( ( -LRB- cord-010092-uftc8inx 12389 16 RBC RBC NNP cord-010092-uftc8inx 12389 17 ) ) -RRB- cord-010092-uftc8inx 12389 18 engraftment engraftment NN cord-010092-uftc8inx 12389 19 and and CC cord-010092-uftc8inx 12389 20 incidence incidence NN cord-010092-uftc8inx 12389 21 of of IN cord-010092-uftc8inx 12389 22 graft graft NN cord-010092-uftc8inx 12389 23 - - HYPH cord-010092-uftc8inx 12389 24 versus versus NN cord-010092-uftc8inx 12389 25 Patients patient NNS cord-010092-uftc8inx 12389 26 were be VBD cord-010092-uftc8inx 12389 27 categorized categorize VBN cord-010092-uftc8inx 12389 28 according accord VBG cord-010092-uftc8inx 12389 29 to to IN cord-010092-uftc8inx 12389 30 ABO ABO NNP cord-010092-uftc8inx 12389 31 compatible compatible JJ cord-010092-uftc8inx 12389 32 and and CC cord-010092-uftc8inx 12389 33 mismatched mismatched JJ cord-010092-uftc8inx 12389 34 groups group NNS cord-010092-uftc8inx 12389 35 ; ; : cord-010092-uftc8inx 12389 36 these these DT cord-010092-uftc8inx 12389 37 were be VBD cord-010092-uftc8inx 12389 38 further further RB cord-010092-uftc8inx 12389 39 sub sub NN cord-010092-uftc8inx 12389 40 - - HYPH cord-010092-uftc8inx 12389 41 categorized categorize VBN cord-010092-uftc8inx 12389 42 into into IN cord-010092-uftc8inx 12389 43 major major JJ cord-010092-uftc8inx 12389 44 , , , cord-010092-uftc8inx 12389 45 minor minor JJ cord-010092-uftc8inx 12389 46 and and CC cord-010092-uftc8inx 12389 47 bidirectional bidirectional JJ cord-010092-uftc8inx 12389 48 . . . cord-010092-uftc8inx 12390 1 Direct Direct NNP cord-010092-uftc8inx 12390 2 Coombs Coombs NNP cord-010092-uftc8inx 12390 3 test test NN cord-010092-uftc8inx 12390 4 ( ( -LRB- cord-010092-uftc8inx 12390 5 DCT DCT NNP cord-010092-uftc8inx 12390 6 ) ) -RRB- cord-010092-uftc8inx 12390 7 was be VBD cord-010092-uftc8inx 12390 8 performed perform VBN cord-010092-uftc8inx 12390 9 when when WRB cord-010092-uftc8inx 12390 10 hemolysis hemolysis NN cord-010092-uftc8inx 12390 11 was be VBD cord-010092-uftc8inx 12390 12 suspected suspect VBN cord-010092-uftc8inx 12390 13 in in IN cord-010092-uftc8inx 12390 14 the the DT cord-010092-uftc8inx 12390 15 post post JJ cord-010092-uftc8inx 12390 16 - - JJ cord-010092-uftc8inx 12390 17 transplantation transplantation JJ cord-010092-uftc8inx 12390 18 period period NN cord-010092-uftc8inx 12390 19 along along IN cord-010092-uftc8inx 12390 20 with with IN cord-010092-uftc8inx 12390 21 serum serum NN cord-010092-uftc8inx 12390 22 Lactate lactate NN cord-010092-uftc8inx 12390 23 dehydrogenase dehydrogenase NN cord-010092-uftc8inx 12390 24 ( ( -LRB- cord-010092-uftc8inx 12390 25 LDH LDH NNP cord-010092-uftc8inx 12390 26 ) ) -RRB- cord-010092-uftc8inx 12390 27 5 5 CD cord-010092-uftc8inx 12390 28 % % NN cord-010092-uftc8inx 12390 29 ) ) -RRB- cord-010092-uftc8inx 12390 30 were be VBD cord-010092-uftc8inx 12390 31 male male JJ cord-010092-uftc8inx 12390 32 and and CC cord-010092-uftc8inx 12390 33 31(36.5 31(36.5 CD cord-010092-uftc8inx 12390 34 % % NN cord-010092-uftc8inx 12390 35 ) ) -RRB- cord-010092-uftc8inx 12390 36 female female NN cord-010092-uftc8inx 12390 37 . . . cord-010092-uftc8inx 12391 1 Mean mean JJ cord-010092-uftc8inx 12391 2 age age NN cord-010092-uftc8inx 12391 3 of of IN cord-010092-uftc8inx 12391 4 ABO ABO NNP cord-010092-uftc8inx 12391 5 matched match VBD cord-010092-uftc8inx 12391 6 and and CC cord-010092-uftc8inx 12391 7 mismatched mismatched JJ cord-010092-uftc8inx 12391 8 groups group NNS cord-010092-uftc8inx 12391 9 were be VBD cord-010092-uftc8inx 12391 10 ( ( -LRB- cord-010092-uftc8inx 12391 11 6.99 6.99 CD cord-010092-uftc8inx 12391 12 AE AE NNP cord-010092-uftc8inx 12391 13 4.6 4.6 CD cord-010092-uftc8inx 12391 14 ) ) -RRB- cord-010092-uftc8inx 12391 15 years year NNS cord-010092-uftc8inx 12391 16 . . . cord-010092-uftc8inx 12392 1 Most Most JJS cord-010092-uftc8inx 12392 2 common common JJ cord-010092-uftc8inx 12392 3 indications indication NNS cord-010092-uftc8inx 12392 4 for for IN cord-010092-uftc8inx 12392 5 transplant transplant NN cord-010092-uftc8inx 12392 6 included include VBN cord-010092-uftc8inx 12392 7 beta beta NN cord-010092-uftc8inx 12392 8 thalassemia thalassemia NN cord-010092-uftc8inx 12392 9 major major JJ cord-010092-uftc8inx 12392 10 53(60.2 53(60.2 CD cord-010092-uftc8inx 12392 11 % % NN cord-010092-uftc8inx 12392 12 ) ) -RRB- cord-010092-uftc8inx 12392 13 , , , cord-010092-uftc8inx 12392 14 aplastic aplastic JJ cord-010092-uftc8inx 12392 15 anemia anemia NN cord-010092-uftc8inx 12392 16 in in IN cord-010092-uftc8inx 12392 17 25(28.4 25(28.4 CD cord-010092-uftc8inx 12392 18 ) ) -RRB- cord-010092-uftc8inx 12392 19 and and CC cord-010092-uftc8inx 12392 20 pure pure JJ cord-010092-uftc8inx 12392 21 red red JJ cord-010092-uftc8inx 12392 22 cell cell NN cord-010092-uftc8inx 12392 23 aplasia aplasia NNP cord-010092-uftc8inx 12392 24 2(2.35 2(2.35 CD cord-010092-uftc8inx 12392 25 % % NN cord-010092-uftc8inx 12392 26 ) ) -RRB- cord-010092-uftc8inx 12392 27 . . . cord-010092-uftc8inx 12393 1 Source source NN cord-010092-uftc8inx 12393 2 of of IN cord-010092-uftc8inx 12393 3 stem stem NN cord-010092-uftc8inx 12393 4 cell cell NN cord-010092-uftc8inx 12393 5 was be VBD cord-010092-uftc8inx 12393 6 bone bone NN cord-010092-uftc8inx 12393 7 marrow marrow NN cord-010092-uftc8inx 12393 8 in in IN cord-010092-uftc8inx 12393 9 45 45 CD cord-010092-uftc8inx 12393 10 and and CC cord-010092-uftc8inx 12393 11 peripheral peripheral JJ cord-010092-uftc8inx 12393 12 blood blood NN cord-010092-uftc8inx 12394 1 40 40 CD cord-010092-uftc8inx 12394 2 patients patient NNS cord-010092-uftc8inx 12394 3 ABO ABO NNP cord-010092-uftc8inx 12394 4 matched match VBD cord-010092-uftc8inx 12394 5 while while IN cord-010092-uftc8inx 12394 6 ABO ABO NNP cord-010092-uftc8inx 12394 7 mismatched mismatch VBD cord-010092-uftc8inx 12394 8 group group NN cord-010092-uftc8inx 12394 9 comprised comprise VBN cord-010092-uftc8inx 12394 10 of of IN cord-010092-uftc8inx 12394 11 28(32.9 28(32.9 CD cord-010092-uftc8inx 12394 12 % % NN cord-010092-uftc8inx 12394 13 ) ) -RRB- cord-010092-uftc8inx 12394 14 patients patient NNS cord-010092-uftc8inx 12394 15 with with IN cord-010092-uftc8inx 12394 16 further further JJ cord-010092-uftc8inx 12394 17 subdivision subdivision NN cord-010092-uftc8inx 12394 18 into into IN cord-010092-uftc8inx 12394 19 major major JJ cord-010092-uftc8inx 12394 20 ( ( -LRB- cord-010092-uftc8inx 12394 21 n n NN cord-010092-uftc8inx 12394 22 = = SYM cord-010092-uftc8inx 12394 23 13 13 CD cord-010092-uftc8inx 12394 24 ) ) -RRB- cord-010092-uftc8inx 12394 25 , , , cord-010092-uftc8inx 12394 26 minor minor JJ cord-010092-uftc8inx 12394 27 ( ( -LRB- cord-010092-uftc8inx 12394 28 n n NN cord-010092-uftc8inx 12394 29 = = SYM cord-010092-uftc8inx 12394 30 13 13 CD cord-010092-uftc8inx 12394 31 ) ) -RRB- cord-010092-uftc8inx 12394 32 and and CC cord-010092-uftc8inx 12394 33 bidirectional bidirectional JJ cord-010092-uftc8inx 12395 1 In in IN cord-010092-uftc8inx 12395 2 the the DT cord-010092-uftc8inx 12395 3 post post NN cord-010092-uftc8inx 12395 4 transplantation transplantation NN cord-010092-uftc8inx 12395 5 period period NN cord-010092-uftc8inx 12395 6 , , , cord-010092-uftc8inx 12395 7 packed pack VBN cord-010092-uftc8inx 12395 8 red red JJ cord-010092-uftc8inx 12395 9 blood blood NN cord-010092-uftc8inx 12395 10 cell cell NN cord-010092-uftc8inx 12395 11 and and CC cord-010092-uftc8inx 12395 12 platelets platelet NNS cord-010092-uftc8inx 12395 13 were be VBD cord-010092-uftc8inx 12395 14 transfused transfuse VBN cord-010092-uftc8inx 12395 15 in in IN cord-010092-uftc8inx 12395 16 matched match VBN cord-010092-uftc8inx 12395 17 group group NN cord-010092-uftc8inx 12395 18 ( ( -LRB- cord-010092-uftc8inx 12395 19 n n NN cord-010092-uftc8inx 12395 20 = = SYM cord-010092-uftc8inx 12395 21 401 401 CD cord-010092-uftc8inx 12395 22 ) ) -RRB- cord-010092-uftc8inx 12395 23 and and CC cord-010092-uftc8inx 12395 24 ( ( -LRB- cord-010092-uftc8inx 12395 25 n n NN cord-010092-uftc8inx 12395 26 = = SYM cord-010092-uftc8inx 12395 27 1837 1837 CD cord-010092-uftc8inx 12395 28 ) ) -RRB- cord-010092-uftc8inx 12396 1 comparably(n comparably(n JJ cord-010092-uftc8inx 12396 2 = = SYM cord-010092-uftc8inx 12396 3 102 102 CD cord-010092-uftc8inx 12396 4 ) ) -RRB- cord-010092-uftc8inx 12397 1 and and CC cord-010092-uftc8inx 12397 2 ( ( -LRB- cord-010092-uftc8inx 12397 3 n n NN cord-010092-uftc8inx 12397 4 = = SYM cord-010092-uftc8inx 12397 5 480 480 CD cord-010092-uftc8inx 12397 6 ) ) -RRB- cord-010092-uftc8inx 12397 7 in in IN cord-010092-uftc8inx 12397 8 mismatched mismatched JJ cord-010092-uftc8inx 12397 9 group group NN cord-010092-uftc8inx 12397 10 . . . cord-010092-uftc8inx 12398 1 Primary primary JJ cord-010092-uftc8inx 12398 2 and and CC cord-010092-uftc8inx 12398 3 secondary secondary JJ cord-010092-uftc8inx 12398 4 graft graft NN cord-010092-uftc8inx 12398 5 failure failure NN cord-010092-uftc8inx 12398 6 in in IN cord-010092-uftc8inx 12398 7 matched match VBN cord-010092-uftc8inx 12398 8 group group NN cord-010092-uftc8inx 12398 9 was be VBD cord-010092-uftc8inx 12398 10 8.77 8.77 CD cord-010092-uftc8inx 12398 11 % % NN cord-010092-uftc8inx 12398 12 and and CC cord-010092-uftc8inx 12398 13 12.28 12.28 CD cord-010092-uftc8inx 12398 14 % % NN cord-010092-uftc8inx 12398 15 patients patient NNS cord-010092-uftc8inx 12398 16 while while IN cord-010092-uftc8inx 12398 17 in in IN cord-010092-uftc8inx 12398 18 mismatched mismatched JJ cord-010092-uftc8inx 12398 19 group group NN cord-010092-uftc8inx 12398 20 graft graft NN cord-010092-uftc8inx 12398 21 failure failure NN cord-010092-uftc8inx 12398 22 was be VBD cord-010092-uftc8inx 12398 23 observed observe VBN cord-010092-uftc8inx 12398 24 in in IN cord-010092-uftc8inx 12398 25 4(14.28 4(14.28 CD cord-010092-uftc8inx 12398 26 % % NN cord-010092-uftc8inx 12398 27 ) ) -RRB- cord-010092-uftc8inx 12398 28 patients patient NNS cord-010092-uftc8inx 12398 29 respectively respectively RB cord-010092-uftc8inx 12398 30 . . . cord-010092-uftc8inx 12399 1 Positive positive JJ cord-010092-uftc8inx 12399 2 DCT dct NN cord-010092-uftc8inx 12399 3 in in IN cord-010092-uftc8inx 12399 4 ABO ABO NNP cord-010092-uftc8inx 12399 5 matched match VBD cord-010092-uftc8inx 12399 6 group group NN cord-010092-uftc8inx 12399 7 in in IN cord-010092-uftc8inx 12399 8 1(1.75 1(1.75 CD cord-010092-uftc8inx 12399 9 % % NN cord-010092-uftc8inx 12399 10 ) ) -RRB- cord-010092-uftc8inx 12399 11 patient patient NN cord-010092-uftc8inx 12399 12 , , , cord-010092-uftc8inx 12399 13 whereas whereas IN cord-010092-uftc8inx 12399 14 2(7.14 2(7.14 CD cord-010092-uftc8inx 12399 15 % % NN cord-010092-uftc8inx 12399 16 ) ) -RRB- cord-010092-uftc8inx 12399 17 patients patient NNS cord-010092-uftc8inx 12399 18 with with IN cord-010092-uftc8inx 12399 19 major major JJ cord-010092-uftc8inx 12399 20 and and CC cord-010092-uftc8inx 12399 21 minor minor JJ cord-010092-uftc8inx 12399 22 ABO ABO NNP cord-010092-uftc8inx 12399 23 mismatch mismatch NN cord-010092-uftc8inx 12399 24 group group NN cord-010092-uftc8inx 12399 25 with with IN cord-010092-uftc8inx 12399 26 raised raise VBN cord-010092-uftc8inx 12399 27 LDH LDH NNP cord-010092-uftc8inx 12399 28 levels level NNS cord-010092-uftc8inx 12399 29 and and CC cord-010092-uftc8inx 12399 30 deranged deranged JJ cord-010092-uftc8inx 12399 31 LFTs lft NNS cord-010092-uftc8inx 12399 32 were be VBD cord-010092-uftc8inx 12399 33 found find VBN cord-010092-uftc8inx 12399 34 . . . cord-010092-uftc8inx 12400 1 Episodes episode NNS cord-010092-uftc8inx 12400 2 of of IN cord-010092-uftc8inx 12400 3 acute acute JJ cord-010092-uftc8inx 12400 4 and and CC cord-010092-uftc8inx 12400 5 chronic chronic JJ cord-010092-uftc8inx 12400 6 GVHD GVHD NNP cord-010092-uftc8inx 12400 7 in in IN cord-010092-uftc8inx 12400 8 ABO ABO NNP cord-010092-uftc8inx 12401 1 compatible compatible JJ cord-010092-uftc8inx 12401 2 and and CC cord-010092-uftc8inx 12401 3 incompatible incompatible JJ cord-010092-uftc8inx 12401 4 groups group NNS cord-010092-uftc8inx 12401 5 were be VBD cord-010092-uftc8inx 12401 6 insignificant insignificant JJ cord-010092-uftc8inx 12401 7 . . . cord-010092-uftc8inx 12402 1 Overall overall JJ cord-010092-uftc8inx 12402 2 survival survival NN cord-010092-uftc8inx 12402 3 in in IN cord-010092-uftc8inx 12402 4 ABO ABO NNP cord-010092-uftc8inx 12402 5 Summary Summary NNP cord-010092-uftc8inx 12402 6 / / SYM cord-010092-uftc8inx 12402 7 Conclusions Conclusions NNPS cord-010092-uftc8inx 12402 8 : : : cord-010092-uftc8inx 12403 1 These these DT cord-010092-uftc8inx 12403 2 results result NNS cord-010092-uftc8inx 12403 3 indicate indicate VBP cord-010092-uftc8inx 12403 4 that that IN cord-010092-uftc8inx 12403 5 ABO ABO NNP cord-010092-uftc8inx 12403 6 incompatibility incompatibility NN cord-010092-uftc8inx 12403 7 does do VBZ cord-010092-uftc8inx 12403 8 not not RB cord-010092-uftc8inx 12403 9 seem seem VB cord-010092-uftc8inx 12403 10 to to TO cord-010092-uftc8inx 12403 11 influence influence VB cord-010092-uftc8inx 12403 12 outcome outcome NN cord-010092-uftc8inx 12403 13 of of IN cord-010092-uftc8inx 12403 14 the the DT cord-010092-uftc8inx 12403 15 patients patient NNS cord-010092-uftc8inx 12403 16 undergoing undergo VBG cord-010092-uftc8inx 12403 17 allogeneic allogeneic IN cord-010092-uftc8inx 12403 18 hematopoietic hematopoietic JJ cord-010092-uftc8inx 12403 19 stem stem NN cord-010092-uftc8inx 12403 20 cell cell NN cord-010092-uftc8inx 12403 21 transplantation transplantation NN cord-010092-uftc8inx 12403 22 . . . cord-010092-uftc8inx 12404 1 Careful careful JJ cord-010092-uftc8inx 12404 2 monitoring monitoring NN cord-010092-uftc8inx 12404 3 of of IN cord-010092-uftc8inx 12404 4 patients patient NNS cord-010092-uftc8inx 12404 5 can can MD cord-010092-uftc8inx 12404 6 help help VB cord-010092-uftc8inx 12404 7 detect detect VB cord-010092-uftc8inx 12404 8 problems problem NNS cord-010092-uftc8inx 12404 9 early early RB cord-010092-uftc8inx 12404 10 and and CC cord-010092-uftc8inx 12404 11 treat treat VB cord-010092-uftc8inx 12404 12 them -PRON- PRP cord-010092-uftc8inx 12404 13 efficiently efficiently RB cord-010092-uftc8inx 12404 14 , , , cord-010092-uftc8inx 12404 15 thus thus RB cord-010092-uftc8inx 12404 16 , , , cord-010092-uftc8inx 12404 17 reducing reduce VBG cord-010092-uftc8inx 12404 18 the the DT cord-010092-uftc8inx 12404 19 number number NN cord-010092-uftc8inx 12404 20 of of IN cord-010092-uftc8inx 12404 21 life life NN cord-010092-uftc8inx 12404 22 threatening threaten VBG cord-010092-uftc8inx 12404 23 events event NNS cord-010092-uftc8inx 12405 1 A a DT cord-010092-uftc8inx 12405 2 Picascia Picascia NNP cord-010092-uftc8inx 12405 3 1 1 CD cord-010092-uftc8inx 12405 4 , , , cord-010092-uftc8inx 12405 5 C C NNP cord-010092-uftc8inx 12405 6 Sabia Sabia NNP cord-010092-uftc8inx 12405 7 1 1 CD cord-010092-uftc8inx 12405 8 , , , cord-010092-uftc8inx 12405 9 F F NNP cord-010092-uftc8inx 12405 10 Cavalca Cavalca NNP cord-010092-uftc8inx 12405 11 1 1 CD cord-010092-uftc8inx 12405 12 , , , cord-010092-uftc8inx 12405 13 G G NNP cord-010092-uftc8inx 12405 14 Nicoletti Nicoletti NNP cord-010092-uftc8inx 12405 15 2 2 CD cord-010092-uftc8inx 12405 16 and and CC cord-010092-uftc8inx 12405 17 C C NNP cord-010092-uftc8inx 12405 18 Napoli Napoli NNP cord-010092-uftc8inx 12405 19 1 1 CD cord-010092-uftc8inx 12406 1 In in IN cord-010092-uftc8inx 12406 2 our -PRON- PRP$ cord-010092-uftc8inx 12406 3 routine routine JJ cord-010092-uftc8inx 12406 4 work work NN cord-010092-uftc8inx 12406 5 with with IN cord-010092-uftc8inx 12406 6 One one CD cord-010092-uftc8inx 12406 7 Lambda Lambda NNP cord-010092-uftc8inx 12406 8 SAB SAB NNP cord-010092-uftc8inx 12406 9 class class NN cord-010092-uftc8inx 12406 10 II ii CD cord-010092-uftc8inx 12406 11 reagents reagent NNS cord-010092-uftc8inx 12406 12 , , , cord-010092-uftc8inx 12406 13 we -PRON- PRP cord-010092-uftc8inx 12406 14 observed observe VBD cord-010092-uftc8inx 12406 15 non non JJ cord-010092-uftc8inx 12406 16 - - JJ cord-010092-uftc8inx 12406 17 specific specific JJ cord-010092-uftc8inx 12406 18 reactivity reactivity NN cord-010092-uftc8inx 12406 19 with with IN cord-010092-uftc8inx 12406 20 some some DT cord-010092-uftc8inx 12406 21 beads bead NNS cord-010092-uftc8inx 12406 22 bearing bear VBG cord-010092-uftc8inx 12406 23 DR4 DR4 NNP cord-010092-uftc8inx 12407 1 and and CC cord-010092-uftc8inx 12407 2 DR16 DR16 NNP cord-010092-uftc8inx 12407 3 in in IN cord-010092-uftc8inx 12407 4 patients patient NNS cord-010092-uftc8inx 12407 5 without without IN cord-010092-uftc8inx 12407 6 sensitizing sensitize VBG cord-010092-uftc8inx 12407 7 events event NNS cord-010092-uftc8inx 12407 8 . . . cord-010092-uftc8inx 12408 1 This this DT cord-010092-uftc8inx 12408 2 pattern pattern NN cord-010092-uftc8inx 12408 3 was be VBD cord-010092-uftc8inx 12408 4 not not RB cord-010092-uftc8inx 12408 5 confirmed confirm VBN cord-010092-uftc8inx 12408 6 by by IN cord-010092-uftc8inx 12408 7 testing test VBG cord-010092-uftc8inx 12408 8 same same JJ cord-010092-uftc8inx 12408 9 sera sera NNP cord-010092-uftc8inx 12408 10 with with IN cord-010092-uftc8inx 12408 11 screening screening NN cord-010092-uftc8inx 12408 12 - - : cord-010092-uftc8inx 12408 13 and and CC cord-010092-uftc8inx 12408 14 PRA PRA NNP cord-010092-uftc8inx 12408 15 - - HYPH cord-010092-uftc8inx 12408 16 beads bead NNS cord-010092-uftc8inx 12408 17 suggesting suggest VBG cord-010092-uftc8inx 12408 18 non non JJ cord-010092-uftc8inx 12408 19 - - JJ cord-010092-uftc8inx 12408 20 specific specific JJ cord-010092-uftc8inx 12408 21 reactions reaction NNS cord-010092-uftc8inx 12408 22 . . . cord-010092-uftc8inx 12409 1 Aims aim VBZ cord-010092-uftc8inx 12409 2 : : : cord-010092-uftc8inx 12410 1 Here here RB cord-010092-uftc8inx 12410 2 , , , cord-010092-uftc8inx 12410 3 we -PRON- PRP cord-010092-uftc8inx 12410 4 sought seek VBD cord-010092-uftc8inx 12410 5 to to TO cord-010092-uftc8inx 12410 6 determine determine VB cord-010092-uftc8inx 12410 7 if if IN cord-010092-uftc8inx 12410 8 fetal fetal JJ cord-010092-uftc8inx 12410 9 bovine bovine JJ cord-010092-uftc8inx 12410 10 serum serum NN cord-010092-uftc8inx 12410 11 ( ( -LRB- cord-010092-uftc8inx 12410 12 FBS FBS NNP cord-010092-uftc8inx 12410 13 ) ) -RRB- cord-010092-uftc8inx 12410 14 treatment treatment NN cord-010092-uftc8inx 12410 15 would would MD cord-010092-uftc8inx 12410 16 be be VB cord-010092-uftc8inx 12410 17 effective effective JJ cord-010092-uftc8inx 12410 18 in in IN cord-010092-uftc8inx 12410 19 reducing reduce VBG cord-010092-uftc8inx 12410 20 / / SYM cord-010092-uftc8inx 12410 21 eliminating eliminate VBG cord-010092-uftc8inx 12410 22 non non JJ cord-010092-uftc8inx 12410 23 - - JJ cord-010092-uftc8inx 12410 24 specific specific JJ cord-010092-uftc8inx 12410 25 reactivity reactivity NN cord-010092-uftc8inx 12410 26 . . . cord-010092-uftc8inx 12411 1 Methods method NNS cord-010092-uftc8inx 12411 2 : : : cord-010092-uftc8inx 12411 3 We -PRON- PRP cord-010092-uftc8inx 12411 4 tested test VBD cord-010092-uftc8inx 12411 5 5 5 CD cord-010092-uftc8inx 12411 6 sera sera NNP cord-010092-uftc8inx 12412 1 pre pre VB cord-010092-uftc8inx 12412 2 - - VBN cord-010092-uftc8inx 12412 3 treated treat VBN cord-010092-uftc8inx 12412 4 with with IN cord-010092-uftc8inx 12412 5 FBS FBS NNP cord-010092-uftc8inx 12412 6 from from IN cord-010092-uftc8inx 12412 7 non non JJ cord-010092-uftc8inx 12412 8 - - JJ cord-010092-uftc8inx 12412 9 sensitized sensitized JJ cord-010092-uftc8inx 12412 10 patients patient NNS cord-010092-uftc8inx 12412 11 that that WDT cord-010092-uftc8inx 12412 12 showed show VBD cord-010092-uftc8inx 12412 13 the the DT cord-010092-uftc8inx 12412 14 DR4 DR4 NNP cord-010092-uftc8inx 12412 15 / / SYM cord-010092-uftc8inx 12412 16 DR16 DR16 NNP cord-010092-uftc8inx 12412 17 pattern pattern NN cord-010092-uftc8inx 12412 18 . . . cord-010092-uftc8inx 12413 1 In in IN cord-010092-uftc8inx 12413 2 particular particular JJ cord-010092-uftc8inx 12413 3 , , , cord-010092-uftc8inx 12413 4 5 5 CD cord-010092-uftc8inx 12413 5 ll will NN cord-010092-uftc8inx 12413 6 of of IN cord-010092-uftc8inx 12413 7 FBS FBS NNP cord-010092-uftc8inx 12413 8 was be VBD cord-010092-uftc8inx 12413 9 added add VBN cord-010092-uftc8inx 12413 10 to to IN cord-010092-uftc8inx 12413 11 95 95 CD cord-010092-uftc8inx 12413 12 ll will NN cord-010092-uftc8inx 12413 13 of of IN cord-010092-uftc8inx 12413 14 patient patient JJ cord-010092-uftc8inx 12413 15 serum serum NN cord-010092-uftc8inx 12413 16 ; ; , cord-010092-uftc8inx 12413 17 incubated incubate VBN cord-010092-uftc8inx 12413 18 for for IN cord-010092-uftc8inx 12413 19 30 30 CD cord-010092-uftc8inx 12413 20 min min NN cord-010092-uftc8inx 12413 21 at at IN cord-010092-uftc8inx 12413 22 37 37 CD cord-010092-uftc8inx 12413 23 ° ° NN cord-010092-uftc8inx 12413 24 C c NN cord-010092-uftc8inx 12413 25 ; ; , cord-010092-uftc8inx 12413 26 centrifuged centrifuge VBN cord-010092-uftc8inx 12413 27 and and CC cord-010092-uftc8inx 12413 28 subsequently subsequently RB cord-010092-uftc8inx 12413 29 tested test VBN cord-010092-uftc8inx 12413 30 in in IN cord-010092-uftc8inx 12413 31 the the DT cord-010092-uftc8inx 12413 32 SAB SAB NNP cord-010092-uftc8inx 12413 33 assay assay NN cord-010092-uftc8inx 12413 34 . . . cord-010092-uftc8inx 12414 1 As as IN cord-010092-uftc8inx 12414 2 controls control NNS cord-010092-uftc8inx 12414 3 , , , cord-010092-uftc8inx 12414 4 we -PRON- PRP cord-010092-uftc8inx 12414 5 treated treat VBD cord-010092-uftc8inx 12414 6 sera sera NNP cord-010092-uftc8inx 12414 7 from from IN cord-010092-uftc8inx 12414 8 5 5 CD cord-010092-uftc8inx 12414 9 patients patient NNS cord-010092-uftc8inx 12414 10 with with IN cord-010092-uftc8inx 12414 11 documented document VBN cord-010092-uftc8inx 12414 12 DSA DSA NNP cord-010092-uftc8inx 12414 13 including include VBG cord-010092-uftc8inx 12414 14 DR4 dr4 NN cord-010092-uftc8inx 12414 15 / / SYM cord-010092-uftc8inx 12414 16 DR16 DR16 NNP cord-010092-uftc8inx 12414 17 and and CC cord-010092-uftc8inx 12414 18 5 5 CD cord-010092-uftc8inx 12414 19 patients patient NNS cord-010092-uftc8inx 12414 20 without without IN cord-010092-uftc8inx 12414 21 HLA HLA NNP cord-010092-uftc8inx 12414 22 antibodies antibody NNS cord-010092-uftc8inx 12414 23 . . . cord-010092-uftc8inx 12415 1 Results result NNS cord-010092-uftc8inx 12415 2 : : : cord-010092-uftc8inx 12416 1 DR4 DR4 NNP cord-010092-uftc8inx 12416 2 / / SYM cord-010092-uftc8inx 12416 3 DR16 DR16 NNP cord-010092-uftc8inx 12416 4 non non JJ cord-010092-uftc8inx 12416 5 - - JJ cord-010092-uftc8inx 12416 6 specific specific JJ cord-010092-uftc8inx 12416 7 reactivity reactivity NN cord-010092-uftc8inx 12416 8 was be VBD cord-010092-uftc8inx 12416 9 eliminated eliminate VBN cord-010092-uftc8inx 12416 10 or or CC cord-010092-uftc8inx 12416 11 significantly significantly RB cord-010092-uftc8inx 12416 12 reduced reduce VBN cord-010092-uftc8inx 12416 13 after after IN cord-010092-uftc8inx 12416 14 FBS FBS NNP cord-010092-uftc8inx 12416 15 treatment treatment NN cord-010092-uftc8inx 12416 16 . . . cord-010092-uftc8inx 12417 1 We -PRON- PRP cord-010092-uftc8inx 12417 2 found find VBD cord-010092-uftc8inx 12417 3 that that IN cord-010092-uftc8inx 12417 4 patients patient NNS cord-010092-uftc8inx 12417 5 with with IN cord-010092-uftc8inx 12417 6 DR4 dr4 NN cord-010092-uftc8inx 12417 7 and and CC cord-010092-uftc8inx 12417 8 DR16 DR16 NNP cord-010092-uftc8inx 12417 9 DSA DSA NNP cord-010092-uftc8inx 12417 10 had have VBD cord-010092-uftc8inx 12417 11 no no DT cord-010092-uftc8inx 12417 12 change change NN cord-010092-uftc8inx 12417 13 in in IN cord-010092-uftc8inx 12417 14 MFI MFI NNP cord-010092-uftc8inx 12417 15 values value NNS cord-010092-uftc8inx 12417 16 and and CC cord-010092-uftc8inx 12417 17 additional additional JJ cord-010092-uftc8inx 12417 18 reactivity reactivity NN cord-010092-uftc8inx 12417 19 was be VBD cord-010092-uftc8inx 12417 20 not not RB cord-010092-uftc8inx 12417 21 observed observe VBN cord-010092-uftc8inx 12417 22 in in IN cord-010092-uftc8inx 12417 23 negative negative JJ cord-010092-uftc8inx 12417 24 FBS FBS NNP cord-010092-uftc8inx 12417 25 treated treat VBN cord-010092-uftc8inx 12417 26 sera sera NNP cord-010092-uftc8inx 12417 27 Transfusion Transfusion NNP cord-010092-uftc8inx 12417 28 Medicine Medicine NNP cord-010092-uftc8inx 12417 29 , , , cord-010092-uftc8inx 12417 30 National National NNP cord-010092-uftc8inx 12417 31 Blood Blood NNP cord-010092-uftc8inx 12417 32 Transfusion Transfusion NNP cord-010092-uftc8inx 12417 33 Centre Centre NNP cord-010092-uftc8inx 12417 34 2 2 CD cord-010092-uftc8inx 12417 35 Transfusion Transfusion NNP cord-010092-uftc8inx 12417 36 Medicine Medicine NNP cord-010092-uftc8inx 12417 37 , , , cord-010092-uftc8inx 12417 38 National National NNP cord-010092-uftc8inx 12417 39 Blood Blood NNP cord-010092-uftc8inx 12417 40 Transfusion Transfusion NNP cord-010092-uftc8inx 12417 41 Center Center NNP cord-010092-uftc8inx 12417 42 3 3 CD cord-010092-uftc8inx 12417 43 Transfusion Transfusion NNP cord-010092-uftc8inx 12417 44 Medicine Medicine NNP cord-010092-uftc8inx 12417 45 , , , cord-010092-uftc8inx 12417 46 National National NNP cord-010092-uftc8inx 12417 47 Blood Blood NNP cord-010092-uftc8inx 12417 48 Transfusion Transfusion NNP cord-010092-uftc8inx 12417 49 Centre Centre NNP cord-010092-uftc8inx 12417 50 , , , cord-010092-uftc8inx 12417 51 Tirana Tirana NNP cord-010092-uftc8inx 12417 52 , , , cord-010092-uftc8inx 12417 53 Albania Albania NNP cord-010092-uftc8inx 12417 54 Background Background NNP cord-010092-uftc8inx 12417 55 : : : cord-010092-uftc8inx 12417 56 ABO ABO NNP cord-010092-uftc8inx 12417 57 blood blood NN cord-010092-uftc8inx 12417 58 group group NN cord-010092-uftc8inx 12417 59 , , , cord-010092-uftc8inx 12417 60 has have VBZ cord-010092-uftc8inx 12417 61 been be VBN cord-010092-uftc8inx 12417 62 associated associate VBN cord-010092-uftc8inx 12417 63 with with IN cord-010092-uftc8inx 12417 64 many many JJ cord-010092-uftc8inx 12417 65 diseases disease NNS cord-010092-uftc8inx 12417 66 , , , cord-010092-uftc8inx 12417 67 although although IN cord-010092-uftc8inx 12417 68 the the DT cord-010092-uftc8inx 12417 69 explanation explanation NN cord-010092-uftc8inx 12417 70 for for IN cord-010092-uftc8inx 12417 71 ABO ABO NNP cord-010092-uftc8inx 12417 72 's 's POS cord-010092-uftc8inx 12417 73 blood blood NN cord-010092-uftc8inx 12417 74 group group NN cord-010092-uftc8inx 12417 75 association association NN cord-010092-uftc8inx 12417 76 and and CC cord-010092-uftc8inx 12417 77 some some DT cord-010092-uftc8inx 12417 78 illnesses illness NNS cord-010092-uftc8inx 12417 79 is be VBZ cord-010092-uftc8inx 12417 80 still still RB cord-010092-uftc8inx 12417 81 unclear unclear JJ cord-010092-uftc8inx 12417 82 . . . cord-010092-uftc8inx 12418 1 Aims aim VBZ cord-010092-uftc8inx 12418 2 : : : cord-010092-uftc8inx 12419 1 To to TO cord-010092-uftc8inx 12419 2 find find VB cord-010092-uftc8inx 12419 3 the the DT cord-010092-uftc8inx 12419 4 distribution distribution NN cord-010092-uftc8inx 12419 5 of of IN cord-010092-uftc8inx 12419 6 cases case NNS cord-010092-uftc8inx 12419 7 by by IN cord-010092-uftc8inx 12419 8 blood blood NN cord-010092-uftc8inx 12419 9 groups group NNS cord-010092-uftc8inx 12419 10 in in IN cord-010092-uftc8inx 12419 11 patients patient NNS cord-010092-uftc8inx 12419 12 with with IN cord-010092-uftc8inx 12419 13 malignant malignant JJ cord-010092-uftc8inx 12419 14 pathology pathology NN cord-010092-uftc8inx 12419 15 compared compare VBN cord-010092-uftc8inx 12419 16 to to IN cord-010092-uftc8inx 12419 17 donors donor NNS cord-010092-uftc8inx 12419 18 in in IN cord-010092-uftc8inx 12419 19 order order NN cord-010092-uftc8inx 12419 20 to to TO cord-010092-uftc8inx 12419 21 assess assess VB cord-010092-uftc8inx 12419 22 the the DT cord-010092-uftc8inx 12419 23 presence presence NN cord-010092-uftc8inx 12419 24 of of IN cord-010092-uftc8inx 12419 25 the the DT cord-010092-uftc8inx 12419 26 ABO ABO NNP cord-010092-uftc8inx 12419 27 blood blood NN cord-010092-uftc8inx 12419 28 group group NN cord-010092-uftc8inx 12419 29 as as IN cord-010092-uftc8inx 12419 30 an an DT cord-010092-uftc8inx 12419 31 epidemiological epidemiological JJ cord-010092-uftc8inx 12419 32 indicator indicator NN cord-010092-uftc8inx 12419 33 to to TO cord-010092-uftc8inx 12419 34 identify identify VB cord-010092-uftc8inx 12419 35 populations population NNS cord-010092-uftc8inx 12419 36 exposed expose VBN cord-010092-uftc8inx 12419 37 to to IN cord-010092-uftc8inx 12419 38 different different JJ cord-010092-uftc8inx 12419 39 malignant malignant JJ cord-010092-uftc8inx 12419 40 pathologies pathology NNS cord-010092-uftc8inx 12419 41 Methods method NNS cord-010092-uftc8inx 12419 42 : : : cord-010092-uftc8inx 12419 43 We -PRON- PRP cord-010092-uftc8inx 12419 44 conducted conduct VBD cord-010092-uftc8inx 12419 45 a a DT cord-010092-uftc8inx 12419 46 case case NN cord-010092-uftc8inx 12419 47 - - HYPH cord-010092-uftc8inx 12419 48 control control NN cord-010092-uftc8inx 12419 49 study study NN cord-010092-uftc8inx 12419 50 . . . cord-010092-uftc8inx 12420 1 ABO ABO NNP cord-010092-uftc8inx 12420 2 blood blood NN cord-010092-uftc8inx 12420 3 group group NN cord-010092-uftc8inx 12420 4 and and CC cord-010092-uftc8inx 12420 5 diagnosis diagnosis NN cord-010092-uftc8inx 12420 6 of of IN cord-010092-uftc8inx 12420 7 all all DT cord-010092-uftc8inx 12420 8 patients patient NNS cord-010092-uftc8inx 12420 9 have have VBP cord-010092-uftc8inx 12420 10 been be VBN cord-010092-uftc8inx 12420 11 studied study VBN cord-010092-uftc8inx 12420 12 . . . cord-010092-uftc8inx 12421 1 The the DT cord-010092-uftc8inx 12421 2 control control NN cord-010092-uftc8inx 12421 3 sample sample NN cord-010092-uftc8inx 12421 4 was be VBD cord-010092-uftc8inx 12421 5 collected collect VBN cord-010092-uftc8inx 12421 6 from from IN cord-010092-uftc8inx 12421 7 17,992 17,992 CD cord-010092-uftc8inx 12421 8 healthy healthy JJ cord-010092-uftc8inx 12421 9 donors donor NNS cord-010092-uftc8inx 12421 10 from from IN cord-010092-uftc8inx 12421 11 which which WDT cord-010092-uftc8inx 12421 12 group group NN cord-010092-uftc8inx 12421 13 A a NN cord-010092-uftc8inx 12421 14 ( ( -LRB- cord-010092-uftc8inx 12421 15 36,8 36,8 CD cord-010092-uftc8inx 12421 16 % % NN cord-010092-uftc8inx 12421 17 ) ) -RRB- cord-010092-uftc8inx 12421 18 , , , cord-010092-uftc8inx 12421 19 group group NN cord-010092-uftc8inx 12421 20 O O NNP cord-010092-uftc8inx 12421 21 ( ( -LRB- cord-010092-uftc8inx 12421 22 41,7 41,7 CD cord-010092-uftc8inx 12421 23 % % NN cord-010092-uftc8inx 12421 24 ) ) -RRB- cord-010092-uftc8inx 12421 25 , , , cord-010092-uftc8inx 12421 26 B B NNP cord-010092-uftc8inx 12421 27 ( ( -LRB- cord-010092-uftc8inx 12421 28 16,2 16,2 CD cord-010092-uftc8inx 12421 29 % % NN cord-010092-uftc8inx 12421 30 ) ) -RRB- cord-010092-uftc8inx 12421 31 and and CC cord-010092-uftc8inx 12421 32 group group NN cord-010092-uftc8inx 12421 33 AB ab NN cord-010092-uftc8inx 12421 34 ( ( -LRB- cord-010092-uftc8inx 12421 35 5,3 5,3 CD cord-010092-uftc8inx 12421 36 % % NN cord-010092-uftc8inx 12421 37 ) ) -RRB- cord-010092-uftc8inx 12421 38 resulted result VBD cord-010092-uftc8inx 12421 39 . . . cord-010092-uftc8inx 12422 1 The the DT cord-010092-uftc8inx 12422 2 study study NN cord-010092-uftc8inx 12422 3 was be VBD cord-010092-uftc8inx 12422 4 conducted conduct VBN cord-010092-uftc8inx 12422 5 in in IN cord-010092-uftc8inx 12422 6 3727 3727 CD cord-010092-uftc8inx 12422 7 patients patient NNS cord-010092-uftc8inx 12422 8 who who WP cord-010092-uftc8inx 12422 9 have have VBP cord-010092-uftc8inx 12422 10 been be VBN cord-010092-uftc8inx 12422 11 transfused transfuse VBN cord-010092-uftc8inx 12422 12 and and CC cord-010092-uftc8inx 12422 13 submitted submit VBD cord-010092-uftc8inx 12422 14 a a DT cord-010092-uftc8inx 12422 15 request request NN cord-010092-uftc8inx 12422 16 to to TO cord-010092-uftc8inx 12422 17 determine determine VB cord-010092-uftc8inx 12422 18 the the DT cord-010092-uftc8inx 12422 19 blood blood NN cord-010092-uftc8inx 12422 20 group group NN cord-010092-uftc8inx 12422 21 at at IN cord-010092-uftc8inx 12422 22 the the DT cord-010092-uftc8inx 12422 23 Blood Blood NNP cord-010092-uftc8inx 12422 24 Bank Bank NNP cord-010092-uftc8inx 12422 25 at at IN cord-010092-uftc8inx 12422 26 QSUT QSUT NNP cord-010092-uftc8inx 12422 27 during during IN cord-010092-uftc8inx 12422 28 the the DT cord-010092-uftc8inx 12422 29 period period NN cord-010092-uftc8inx 12422 30 2011 2011 CD cord-010092-uftc8inx 12422 31 - - SYM cord-010092-uftc8inx 12422 32 2017 2017 CD cord-010092-uftc8inx 12422 33 Results result NNS cord-010092-uftc8inx 12422 34 : : : cord-010092-uftc8inx 12423 1 Among among IN cord-010092-uftc8inx 12423 2 the the DT cord-010092-uftc8inx 12423 3 3727 3727 CD cord-010092-uftc8inx 12423 4 patients patient NNS cord-010092-uftc8inx 12423 5 , , , cord-010092-uftc8inx 12423 6 when when WRB cord-010092-uftc8inx 12423 7 all all DT cord-010092-uftc8inx 12423 8 malignant malignant JJ cord-010092-uftc8inx 12423 9 pathologies pathology NNS cord-010092-uftc8inx 12423 10 were be VBD cord-010092-uftc8inx 12423 11 taken take VBN cord-010092-uftc8inx 12423 12 together together RB cord-010092-uftc8inx 12423 13 , , , cord-010092-uftc8inx 12423 14 the the DT cord-010092-uftc8inx 12423 15 highest high JJS cord-010092-uftc8inx 12423 16 frequency frequency NN cord-010092-uftc8inx 12423 17 was be VBD cord-010092-uftc8inx 12423 18 seen see VBN cord-010092-uftc8inx 12423 19 in in IN cord-010092-uftc8inx 12423 20 blood blood NN cord-010092-uftc8inx 12423 21 group group NN cord-010092-uftc8inx 12423 22 A a NN cord-010092-uftc8inx 12423 23 ( ( -LRB- cord-010092-uftc8inx 12423 24 39.7 39.7 CD cord-010092-uftc8inx 12423 25 % % NN cord-010092-uftc8inx 12423 26 ) ) -RRB- cord-010092-uftc8inx 12423 27 , , , cord-010092-uftc8inx 12423 28 followed follow VBN cord-010092-uftc8inx 12423 29 by by IN cord-010092-uftc8inx 12423 30 0 0 CD cord-010092-uftc8inx 12423 31 ( ( -LRB- cord-010092-uftc8inx 12423 32 39.5 39.5 CD cord-010092-uftc8inx 12423 33 % % NN cord-010092-uftc8inx 12423 34 ) ) -RRB- cord-010092-uftc8inx 12423 35 , , , cord-010092-uftc8inx 12423 36 B b NN cord-010092-uftc8inx 12423 37 ( ( -LRB- cord-010092-uftc8inx 12423 38 15.2 15.2 CD cord-010092-uftc8inx 12423 39 % % NN cord-010092-uftc8inx 12423 40 ) ) -RRB- cord-010092-uftc8inx 12423 41 and and CC cord-010092-uftc8inx 12423 42 AB ab NN cord-010092-uftc8inx 12423 43 ( ( -LRB- cord-010092-uftc8inx 12423 44 5.4 5.4 CD cord-010092-uftc8inx 12423 45 % % NN cord-010092-uftc8inx 12423 46 ) ) -RRB- cord-010092-uftc8inx 12423 47 . . . cord-010092-uftc8inx 12424 1 Group group NN cord-010092-uftc8inx 12424 2 A a DT cord-010092-uftc8inx 12424 3 frequency frequency NN cord-010092-uftc8inx 12424 4 was be VBD cord-010092-uftc8inx 12424 5 higher high JJR cord-010092-uftc8inx 12424 6 and and CC cord-010092-uftc8inx 12424 7 O O NNP cord-010092-uftc8inx 12424 8 was be VBD cord-010092-uftc8inx 12424 9 lower low JJR cord-010092-uftc8inx 12424 10 compared compare VBN cord-010092-uftc8inx 12424 11 to to IN cord-010092-uftc8inx 12424 12 controls control NNS cord-010092-uftc8inx 12424 13 . . . cord-010092-uftc8inx 12425 1 A a DT cord-010092-uftc8inx 12425 2 high high JJ cord-010092-uftc8inx 12425 3 incidence incidence NN cord-010092-uftc8inx 12425 4 of of IN cord-010092-uftc8inx 12425 5 blood blood NN cord-010092-uftc8inx 12425 6 group group NN cord-010092-uftc8inx 12425 7 A A NNP cord-010092-uftc8inx 12425 8 is be VBZ cord-010092-uftc8inx 12425 9 seen see VBN cord-010092-uftc8inx 12425 10 in in IN cord-010092-uftc8inx 12425 11 : : : cord-010092-uftc8inx 12426 1 pancreatic pancreatic JJ cord-010092-uftc8inx 12426 2 cancer cancer NN cord-010092-uftc8inx 12426 3 A a NN cord-010092-uftc8inx 12426 4 ( ( -LRB- cord-010092-uftc8inx 12426 5 42 42 CD cord-010092-uftc8inx 12426 6 % % NN cord-010092-uftc8inx 12426 7 ) ) -RRB- cord-010092-uftc8inx 12426 8 , , , cord-010092-uftc8inx 12426 9 in in IN cord-010092-uftc8inx 12426 10 gastric gastric JJ cord-010092-uftc8inx 12426 11 cancer cancer NN cord-010092-uftc8inx 12426 12 A a NN cord-010092-uftc8inx 12426 13 ( ( -LRB- cord-010092-uftc8inx 12426 14 43 43 CD cord-010092-uftc8inx 12426 15 % % NN cord-010092-uftc8inx 12426 16 ) ) -RRB- cord-010092-uftc8inx 12426 17 , , . cord-010092-uftc8inx 12427 1 colorectal colorectal JJ cord-010092-uftc8inx 12427 2 cancer cancer NN cord-010092-uftc8inx 12427 3 A A NNP cord-010092-uftc8inx 12427 4 ( ( -LRB- cord-010092-uftc8inx 12427 5 39 39 CD cord-010092-uftc8inx 12427 6 , , , cord-010092-uftc8inx 12427 7 6 6 CD cord-010092-uftc8inx 12427 8 % % NN cord-010092-uftc8inx 12427 9 ) ) -RRB- cord-010092-uftc8inx 12427 10 , , , cord-010092-uftc8inx 12427 11 breast breast NN cord-010092-uftc8inx 12427 12 cancer cancer NN cord-010092-uftc8inx 12427 13 A a NN cord-010092-uftc8inx 12427 14 ( ( -LRB- cord-010092-uftc8inx 12427 15 41 41 CD cord-010092-uftc8inx 12427 16 % % NN cord-010092-uftc8inx 12427 17 ) ) -RRB- cord-010092-uftc8inx 12427 18 , , . cord-010092-uftc8inx 12428 1 cervical cervical JJ cord-010092-uftc8inx 12428 2 cancer cancer NN cord-010092-uftc8inx 12428 3 A A NNP cord-010092-uftc8inx 12428 4 ( ( -LRB- cord-010092-uftc8inx 12428 5 43 43 CD cord-010092-uftc8inx 12428 6 % % NN cord-010092-uftc8inx 12428 7 ) ) -RRB- cord-010092-uftc8inx 12428 8 and and CC cord-010092-uftc8inx 12428 9 ovarian ovarian JJ cord-010092-uftc8inx 12428 10 cancer cancer NN cord-010092-uftc8inx 12428 11 A a NN cord-010092-uftc8inx 12428 12 ( ( -LRB- cord-010092-uftc8inx 12428 13 42 42 CD cord-010092-uftc8inx 12428 14 % % NN cord-010092-uftc8inx 12428 15 ) ) -RRB- cord-010092-uftc8inx 12428 16 versus versus IN cord-010092-uftc8inx 12428 17 A a DT cord-010092-uftc8inx 12428 18 ( ( -LRB- cord-010092-uftc8inx 12428 19 36.8 36.8 CD cord-010092-uftc8inx 12428 20 % % NN cord-010092-uftc8inx 12428 21 ) ) -RRB- cord-010092-uftc8inx 12428 22 in in IN cord-010092-uftc8inx 12428 23 the the DT cord-010092-uftc8inx 12428 24 control control NN cord-010092-uftc8inx 12428 25 group group NN cord-010092-uftc8inx 12428 26 . . . cord-010092-uftc8inx 12429 1 A a DT cord-010092-uftc8inx 12429 2 high high JJ cord-010092-uftc8inx 12429 3 incidence incidence NN cord-010092-uftc8inx 12429 4 of of IN cord-010092-uftc8inx 12429 5 blood blood NN cord-010092-uftc8inx 12429 6 B b NN cord-010092-uftc8inx 12429 7 is be VBZ cord-010092-uftc8inx 12429 8 seen see VBN cord-010092-uftc8inx 12429 9 in in IN cord-010092-uftc8inx 12429 10 multiple multiple JJ cord-010092-uftc8inx 12429 11 myeloma myeloma NN cord-010092-uftc8inx 12429 12 B b NN cord-010092-uftc8inx 12429 13 ( ( -LRB- cord-010092-uftc8inx 12429 14 22 22 CD cord-010092-uftc8inx 12429 15 % % NN cord-010092-uftc8inx 12429 16 ) ) -RRB- cord-010092-uftc8inx 12429 17 and and CC cord-010092-uftc8inx 12429 18 cervical cervical JJ cord-010092-uftc8inx 12429 19 cancer cancer NN cord-010092-uftc8inx 12429 20 B b NN cord-010092-uftc8inx 12429 21 ( ( -LRB- cord-010092-uftc8inx 12429 22 20 20 CD cord-010092-uftc8inx 12429 23 % % NN cord-010092-uftc8inx 12429 24 ) ) -RRB- cord-010092-uftc8inx 12430 1 versus versus IN cord-010092-uftc8inx 12430 2 B B NNP cord-010092-uftc8inx 12430 3 ( ( -LRB- cord-010092-uftc8inx 12430 4 16.2 16.2 CD cord-010092-uftc8inx 12430 5 % % NN cord-010092-uftc8inx 12430 6 ) ) -RRB- cord-010092-uftc8inx 12430 7 in in IN cord-010092-uftc8inx 12430 8 the the DT cord-010092-uftc8inx 12430 9 control control NN cord-010092-uftc8inx 12430 10 group group NN cord-010092-uftc8inx 12430 11 . . . cord-010092-uftc8inx 12431 1 Blood blood NN cord-010092-uftc8inx 12431 2 group group NN cord-010092-uftc8inx 12431 3 AB AB NNP cord-010092-uftc8inx 12431 4 has have VBZ cord-010092-uftc8inx 12431 5 a a DT cord-010092-uftc8inx 12431 6 high high JJ cord-010092-uftc8inx 12431 7 incidence incidence NN cord-010092-uftc8inx 12431 8 in in IN cord-010092-uftc8inx 12431 9 malignant malignant JJ cord-010092-uftc8inx 12431 10 lymphoma lymphoma NN cord-010092-uftc8inx 12431 11 AB ab NN cord-010092-uftc8inx 12431 12 ( ( -LRB- cord-010092-uftc8inx 12431 13 10 10 CD cord-010092-uftc8inx 12431 14 % % NN cord-010092-uftc8inx 12431 15 ) ) -RRB- cord-010092-uftc8inx 12432 1 versus versus FW cord-010092-uftc8inx 12432 2 ( ( -LRB- cord-010092-uftc8inx 12432 3 5.3 5.3 CD cord-010092-uftc8inx 12432 4 % % NN cord-010092-uftc8inx 12432 5 ) ) -RRB- cord-010092-uftc8inx 12432 6 in in IN cord-010092-uftc8inx 12432 7 the the DT cord-010092-uftc8inx 12432 8 control control NN cord-010092-uftc8inx 12432 9 group group NN cord-010092-uftc8inx 12432 10 Summary Summary NNP cord-010092-uftc8inx 12432 11 / / SYM cord-010092-uftc8inx 12432 12 Conclusions Conclusions NNPS cord-010092-uftc8inx 12432 13 : : : cord-010092-uftc8inx 12432 14 It -PRON- PRP cord-010092-uftc8inx 12432 15 appears appear VBZ cord-010092-uftc8inx 12432 16 that that IN cord-010092-uftc8inx 12432 17 individuals individual NNS cord-010092-uftc8inx 12432 18 with with IN cord-010092-uftc8inx 12432 19 blood blood NN cord-010092-uftc8inx 12432 20 groups group NNS cord-010092-uftc8inx 12433 1 A a LS cord-010092-uftc8inx 12433 2 , , , cord-010092-uftc8inx 12433 3 B b NN cord-010092-uftc8inx 12433 4 and and CC cord-010092-uftc8inx 12433 5 AB AB NNP cord-010092-uftc8inx 12433 6 are be VBP cord-010092-uftc8inx 12433 7 more more JJR cord-010092-uftc8inx 12433 8 at at IN cord-010092-uftc8inx 12433 9 risk risk NN cord-010092-uftc8inx 12433 10 of of IN cord-010092-uftc8inx 12433 11 developing develop VBG cord-010092-uftc8inx 12433 12 malignant malignant JJ cord-010092-uftc8inx 12433 13 pathologies pathology NNS cord-010092-uftc8inx 12433 14 and and CC cord-010092-uftc8inx 12433 15 individuals individual NNS cord-010092-uftc8inx 12433 16 with with IN cord-010092-uftc8inx 12433 17 blood blood NN cord-010092-uftc8inx 12433 18 group group NN cord-010092-uftc8inx 12434 1 O o UH cord-010092-uftc8inx 12434 2 are be VBP cord-010092-uftc8inx 12434 3 more more RBR cord-010092-uftc8inx 12434 4 protected protect VBN cord-010092-uftc8inx 12434 5 . . . cord-010092-uftc8inx 12435 1 Background background NN cord-010092-uftc8inx 12435 2 : : : cord-010092-uftc8inx 12436 1 The the DT cord-010092-uftc8inx 12436 2 high high JJ cord-010092-uftc8inx 12436 3 homology homology NN cord-010092-uftc8inx 12436 4 and and CC cord-010092-uftc8inx 12436 5 opposite opposite JJ cord-010092-uftc8inx 12436 6 orientation orientation NN cord-010092-uftc8inx 12436 7 of of IN cord-010092-uftc8inx 12436 8 RH RH NNP cord-010092-uftc8inx 12436 9 genes gene NNS cord-010092-uftc8inx 12436 10 promote promote VBP cord-010092-uftc8inx 12436 11 many many JJ cord-010092-uftc8inx 12436 12 rearrangements rearrangement NNS cord-010092-uftc8inx 12436 13 between between IN cord-010092-uftc8inx 12436 14 them -PRON- PRP cord-010092-uftc8inx 12436 15 and and CC cord-010092-uftc8inx 12436 16 generate generate VB cord-010092-uftc8inx 12436 17 a a DT cord-010092-uftc8inx 12436 18 large large JJ cord-010092-uftc8inx 12436 19 number number NN cord-010092-uftc8inx 12436 20 of of IN cord-010092-uftc8inx 12436 21 RHD RHD NNP cord-010092-uftc8inx 12436 22 and and CC cord-010092-uftc8inx 12436 23 RHCE RHCE NNP cord-010092-uftc8inx 12436 24 variants variant NNS cord-010092-uftc8inx 12436 25 which which WDT cord-010092-uftc8inx 12436 26 can can MD cord-010092-uftc8inx 12436 27 be be VB cord-010092-uftc8inx 12436 28 inherited inherit VBN cord-010092-uftc8inx 12436 29 together together RB cord-010092-uftc8inx 12436 30 . . . cord-010092-uftc8inx 12437 1 Several several JJ cord-010092-uftc8inx 12437 2 studies study NNS cord-010092-uftc8inx 12437 3 have have VBP cord-010092-uftc8inx 12437 4 shown show VBN cord-010092-uftc8inx 12437 5 that that IN cord-010092-uftc8inx 12437 6 those those DT cord-010092-uftc8inx 12437 7 Rh Rh NNP cord-010092-uftc8inx 12437 8 variants variant NNS cord-010092-uftc8inx 12437 9 in in IN cord-010092-uftc8inx 12437 10 patients patient NNS cord-010092-uftc8inx 12437 11 with with IN cord-010092-uftc8inx 12437 12 SCD SCD NNP cord-010092-uftc8inx 12437 13 represent represent VBP cord-010092-uftc8inx 12437 14 an an DT cord-010092-uftc8inx 12437 15 additional additional JJ cord-010092-uftc8inx 12437 16 risk risk NN cord-010092-uftc8inx 12437 17 for for IN cord-010092-uftc8inx 12437 18 alloimmunization alloimmunization NN cord-010092-uftc8inx 12437 19 and and CC cord-010092-uftc8inx 12437 20 delayed delay VBN cord-010092-uftc8inx 12437 21 hemolytic hemolytic JJ cord-010092-uftc8inx 12437 22 transfusion transfusion NN cord-010092-uftc8inx 12437 23 reactions reaction NNS cord-010092-uftc8inx 12437 24 ( ( -LRB- cord-010092-uftc8inx 12437 25 DHTRs dhtr NNS cord-010092-uftc8inx 12437 26 ) ) -RRB- cord-010092-uftc8inx 12437 27 , , , cord-010092-uftc8inx 12437 28 but but CC cord-010092-uftc8inx 12437 29 little little JJ cord-010092-uftc8inx 12437 30 clinical clinical JJ cord-010092-uftc8inx 12437 31 or or CC cord-010092-uftc8inx 12437 32 biological biological JJ cord-010092-uftc8inx 12437 33 evidence evidence NN cord-010092-uftc8inx 12437 34 related relate VBN cord-010092-uftc8inx 12437 35 to to IN cord-010092-uftc8inx 12437 36 alloimmunization alloimmunization NN cord-010092-uftc8inx 12437 37 and and CC cord-010092-uftc8inx 12437 38 DHTR DHTR NNP cord-010092-uftc8inx 12437 39 are be VBP cord-010092-uftc8inx 12437 40 presented present VBN cord-010092-uftc8inx 12437 41 for for IN cord-010092-uftc8inx 12437 42 all all PDT cord-010092-uftc8inx 12437 43 the the DT cord-010092-uftc8inx 12437 44 RH RH NNP cord-010092-uftc8inx 12437 45 variant variant NN cord-010092-uftc8inx 12437 46 alleles allele NNS cord-010092-uftc8inx 12437 47 . . . cord-010092-uftc8inx 12438 1 It -PRON- PRP cord-010092-uftc8inx 12438 2 is be VBZ cord-010092-uftc8inx 12438 3 well well RB cord-010092-uftc8inx 12438 4 established establish VBN cord-010092-uftc8inx 12438 5 that that IN cord-010092-uftc8inx 12438 6 transfusion transfusion NN cord-010092-uftc8inx 12438 7 recipients recipient NNS cord-010092-uftc8inx 12438 8 with with IN cord-010092-uftc8inx 12438 9 the the DT cord-010092-uftc8inx 12438 10 most most RBS cord-010092-uftc8inx 12438 11 common common JJ cord-010092-uftc8inx 12438 12 weak weak JJ cord-010092-uftc8inx 12438 13 D d NN cord-010092-uftc8inx 12438 14 types type NNS cord-010092-uftc8inx 12438 15 1 1 CD cord-010092-uftc8inx 12438 16 , , , cord-010092-uftc8inx 12438 17 2 2 CD cord-010092-uftc8inx 12438 18 and and CC cord-010092-uftc8inx 12438 19 3 3 CD cord-010092-uftc8inx 12438 20 , , , cord-010092-uftc8inx 12438 21 are be VBP cord-010092-uftc8inx 12438 22 not not RB cord-010092-uftc8inx 12438 23 at at IN cord-010092-uftc8inx 12438 24 risk risk NN cord-010092-uftc8inx 12438 25 for for IN cord-010092-uftc8inx 12438 26 forming form VBG cord-010092-uftc8inx 12438 27 alloanti alloanti NNP cord-010092-uftc8inx 12438 28 - - HYPH cord-010092-uftc8inx 12438 29 D D NNP cord-010092-uftc8inx 12438 30 when when WRB cord-010092-uftc8inx 12438 31 exposed expose VBN cord-010092-uftc8inx 12438 32 to to IN cord-010092-uftc8inx 12438 33 conventional conventional JJ cord-010092-uftc8inx 12438 34 RhD rhd NN cord-010092-uftc8inx 12438 35 - - HYPH cord-010092-uftc8inx 12438 36 positive positive JJ cord-010092-uftc8inx 12438 37 RBCs rbc NNS cord-010092-uftc8inx 12438 38 . . . cord-010092-uftc8inx 12439 1 Aims aim VBZ cord-010092-uftc8inx 12439 2 : : : cord-010092-uftc8inx 12440 1 We -PRON- PRP cord-010092-uftc8inx 12440 2 report report VBP cord-010092-uftc8inx 12440 3 here here RB cord-010092-uftc8inx 12440 4 a a DT cord-010092-uftc8inx 12440 5 case case NN cord-010092-uftc8inx 12440 6 of of IN cord-010092-uftc8inx 12440 7 a a DT cord-010092-uftc8inx 12440 8 12-year 12-year JJ cord-010092-uftc8inx 12440 9 - - HYPH cord-010092-uftc8inx 12440 10 old old JJ cord-010092-uftc8inx 12440 11 patient patient NN cord-010092-uftc8inx 12440 12 typed type VBN cord-010092-uftc8inx 12440 13 as as IN cord-010092-uftc8inx 12440 14 weak weak JJ cord-010092-uftc8inx 12440 15 D d NN cord-010092-uftc8inx 12440 16 type type NN cord-010092-uftc8inx 12440 17 3 3 CD cord-010092-uftc8inx 12440 18 , , , cord-010092-uftc8inx 12440 19 receiving receive VBG cord-010092-uftc8inx 12440 20 D+ D+ NNP cord-010092-uftc8inx 12440 21 RBC RBC NNP cord-010092-uftc8inx 12440 22 units unit NNS cord-010092-uftc8inx 12440 23 who who WP cord-010092-uftc8inx 12440 24 presented present VBD cord-010092-uftc8inx 12440 25 anti anti JJ cord-010092-uftc8inx 12440 26 - - JJ cord-010092-uftc8inx 12440 27 D d JJ cord-010092-uftc8inx 12440 28 in in IN cord-010092-uftc8inx 12440 29 his -PRON- PRP$ cord-010092-uftc8inx 12440 30 plasma plasma NN cord-010092-uftc8inx 12440 31 detected detect VBD cord-010092-uftc8inx 12440 32 three three CD cord-010092-uftc8inx 12440 33 weeks week NNS cord-010092-uftc8inx 12440 34 after after IN cord-010092-uftc8inx 12440 35 the the DT cord-010092-uftc8inx 12440 36 last last JJ cord-010092-uftc8inx 12440 37 transfusion transfusion NN cord-010092-uftc8inx 12440 38 . . . cord-010092-uftc8inx 12441 1 Methods method NNS cord-010092-uftc8inx 12441 2 : : : cord-010092-uftc8inx 12441 3 RHD RHD NNP cord-010092-uftc8inx 12441 4 BeadChip BeadChip NNP cord-010092-uftc8inx 12441 5 ( ( -LRB- cord-010092-uftc8inx 12441 6 Immucor Immucor NNP cord-010092-uftc8inx 12441 7 , , , cord-010092-uftc8inx 12441 8 NJ NJ NNP cord-010092-uftc8inx 12441 9 , , , cord-010092-uftc8inx 12441 10 USA USA NNP cord-010092-uftc8inx 12441 11 ) ) -RRB- cord-010092-uftc8inx 12441 12 , , , cord-010092-uftc8inx 12441 13 was be VBD cord-010092-uftc8inx 12441 14 performed perform VBN cord-010092-uftc8inx 12441 15 to to TO cord-010092-uftc8inx 12441 16 identify identify VB cord-010092-uftc8inx 12441 17 the the DT cord-010092-uftc8inx 12441 18 RHD RHD NNP cord-010092-uftc8inx 12441 19 variant variant NN cord-010092-uftc8inx 12441 20 allele allele NN cord-010092-uftc8inx 12441 21 associated associate VBN cord-010092-uftc8inx 12441 22 with with IN cord-010092-uftc8inx 12441 23 the the DT cord-010092-uftc8inx 12441 24 weak weak JJ cord-010092-uftc8inx 12441 25 expression expression NN cord-010092-uftc8inx 12441 26 of of IN cord-010092-uftc8inx 12441 27 D. D. NNP cord-010092-uftc8inx 12441 28 RHCE RHCE NNP cord-010092-uftc8inx 12441 29 genotyping genotyping NN cord-010092-uftc8inx 12441 30 was be VBD cord-010092-uftc8inx 12441 31 performed perform VBN cord-010092-uftc8inx 12441 32 by by IN cord-010092-uftc8inx 12441 33 laboratory laboratory NN cord-010092-uftc8inx 12441 34 developed develop VBN cord-010092-uftc8inx 12441 35 tests test NNS cord-010092-uftc8inx 12441 36 . . . cord-010092-uftc8inx 12442 1 Sequencing Sequencing NNP cord-010092-uftc8inx 12442 2 of of IN cord-010092-uftc8inx 12442 3 RHD RHD NNP cord-010092-uftc8inx 12442 4 , , , cord-010092-uftc8inx 12442 5 RHCE RHCE NNP cord-010092-uftc8inx 12442 6 and and CC cord-010092-uftc8inx 12442 7 RHAG RHAG NNP cord-010092-uftc8inx 12442 8 were be VBD cord-010092-uftc8inx 12442 9 performed perform VBN cord-010092-uftc8inx 12442 10 to to TO cord-010092-uftc8inx 12442 11 determine determine VB cord-010092-uftc8inx 12442 12 if if IN cord-010092-uftc8inx 12442 13 there there EX cord-010092-uftc8inx 12442 14 were be VBD cord-010092-uftc8inx 12442 15 other other JJ cord-010092-uftc8inx 12442 16 mutations mutation NNS cord-010092-uftc8inx 12442 17 that that WDT cord-010092-uftc8inx 12442 18 could could MD cord-010092-uftc8inx 12442 19 explain explain VB cord-010092-uftc8inx 12442 20 the the DT cord-010092-uftc8inx 12442 21 production production NN cord-010092-uftc8inx 12442 22 of of IN cord-010092-uftc8inx 12442 23 alloanti alloanti NNP cord-010092-uftc8inx 12442 24 - - HYPH cord-010092-uftc8inx 12442 25 D. D. NNP cord-010092-uftc8inx 12442 26 Serologic Serologic NNP cord-010092-uftc8inx 12442 27 testing testing NN cord-010092-uftc8inx 12442 28 was be VBD cord-010092-uftc8inx 12442 29 by by IN cord-010092-uftc8inx 12442 30 standard standard JJ cord-010092-uftc8inx 12442 31 hemagglutination hemagglutination NN cord-010092-uftc8inx 12442 32 methods method NNS cord-010092-uftc8inx 12442 33 . . . cord-010092-uftc8inx 12443 1 The the DT cord-010092-uftc8inx 12443 2 clinical clinical JJ cord-010092-uftc8inx 12443 3 significance significance NN cord-010092-uftc8inx 12443 4 of of IN cord-010092-uftc8inx 12443 5 the the DT cord-010092-uftc8inx 12443 6 antibody antibody NN cord-010092-uftc8inx 12443 7 was be VBD cord-010092-uftc8inx 12443 8 evaluated evaluate VBN cord-010092-uftc8inx 12443 9 by by IN cord-010092-uftc8inx 12443 10 monocyte monocyte NNP cord-010092-uftc8inx 12443 11 monolayer monolayer NN cord-010092-uftc8inx 12443 12 assay assay NN cord-010092-uftc8inx 12443 13 ( ( -LRB- cord-010092-uftc8inx 12443 14 MMA MMA NNP cord-010092-uftc8inx 12443 15 ) ) -RRB- cord-010092-uftc8inx 12443 16 . . . cord-010092-uftc8inx 12444 1 Results result NNS cord-010092-uftc8inx 12444 2 : : : cord-010092-uftc8inx 12445 1 Serological serological JJ cord-010092-uftc8inx 12445 2 analysis analysis NN cord-010092-uftc8inx 12445 3 showed show VBD cord-010092-uftc8inx 12445 4 a a DT cord-010092-uftc8inx 12445 5 negative negative JJ cord-010092-uftc8inx 12445 6 DAT dat NN cord-010092-uftc8inx 12445 7 and and CC cord-010092-uftc8inx 12445 8 the the DT cord-010092-uftc8inx 12445 9 presence presence NN cord-010092-uftc8inx 12445 10 of of IN cord-010092-uftc8inx 12445 11 anti anti JJ cord-010092-uftc8inx 12445 12 - - JJ cord-010092-uftc8inx 12445 13 D d JJ cord-010092-uftc8inx 12445 14 in in IN cord-010092-uftc8inx 12445 15 plasma plasma NN cord-010092-uftc8inx 12445 16 ( ( -LRB- cord-010092-uftc8inx 12445 17 2 2 CD cord-010092-uftc8inx 12445 18 + + SYM cord-010092-uftc8inx 12445 19 by by IN cord-010092-uftc8inx 12445 20 gel gel NN cord-010092-uftc8inx 12445 21 ) ) -RRB- cord-010092-uftc8inx 12445 22 . . . cord-010092-uftc8inx 12446 1 Anti Anti NNP cord-010092-uftc8inx 12446 2 - - NNP cord-010092-uftc8inx 12446 3 LW LW NNP cord-010092-uftc8inx 12446 4 was be VBD cord-010092-uftc8inx 12446 5 ruled rule VBN cord-010092-uftc8inx 12446 6 out out RP cord-010092-uftc8inx 12446 7 . . . cord-010092-uftc8inx 12447 1 RHD RHD NNP cord-010092-uftc8inx 12447 2 genotyping genotyping NN cord-010092-uftc8inx 12447 3 revealed reveal VBD cord-010092-uftc8inx 12447 4 the the DT cord-010092-uftc8inx 12447 5 patient patient NN cord-010092-uftc8inx 12447 6 was be VBD cord-010092-uftc8inx 12447 7 RHD*weak RHD*weak NNP cord-010092-uftc8inx 12447 8 D D NNP cord-010092-uftc8inx 12447 9 type type NN cord-010092-uftc8inx 12447 10 3 3 CD cord-010092-uftc8inx 12447 11 . . . cord-010092-uftc8inx 12448 1 RHCE RHCE NNP cord-010092-uftc8inx 12448 2 genotyping genotyping NN cord-010092-uftc8inx 12448 3 predicted predict VBD cord-010092-uftc8inx 12448 4 the the DT cord-010092-uftc8inx 12448 5 D+C+c+E D+C+c+E JJS cord-010092-uftc8inx 12448 6 - - HYPH cord-010092-uftc8inx 12448 7 e+ e+ JJ cord-010092-uftc8inx 12448 8 phenotype phenotype NN cord-010092-uftc8inx 12448 9 . . . cord-010092-uftc8inx 12449 1 Sequencing Sequencing NNP cord-010092-uftc8inx 12449 2 of of IN cord-010092-uftc8inx 12449 3 RHD RHD NNP cord-010092-uftc8inx 12449 4 , , , cord-010092-uftc8inx 12449 5 RHCE RHCE NNP cord-010092-uftc8inx 12449 6 and and CC cord-010092-uftc8inx 12449 7 RHAG RHAG NNP cord-010092-uftc8inx 12449 8 found find VBD cord-010092-uftc8inx 12449 9 no no DT cord-010092-uftc8inx 12449 10 additional additional JJ cord-010092-uftc8inx 12449 11 changes change NNS cord-010092-uftc8inx 12449 12 and and CC cord-010092-uftc8inx 12449 13 confirmed confirm VBD cord-010092-uftc8inx 12449 14 the the DT cord-010092-uftc8inx 12449 15 presence presence NN cord-010092-uftc8inx 12449 16 of of IN cord-010092-uftc8inx 12449 17 RHD*weak RHD*weak NNP cord-010092-uftc8inx 12449 18 D D NNP cord-010092-uftc8inx 12449 19 type type NN cord-010092-uftc8inx 12449 20 3 3 CD cord-010092-uftc8inx 12449 21 . . . cord-010092-uftc8inx 12450 1 MMA MMA NNP cord-010092-uftc8inx 12450 2 showed show VBD cord-010092-uftc8inx 12450 3 the the DT cord-010092-uftc8inx 12450 4 anti anti JJ cord-010092-uftc8inx 12450 5 - - JJ cord-010092-uftc8inx 12450 6 D d JJ cord-010092-uftc8inx 12450 7 was be VBD cord-010092-uftc8inx 12450 8 clinically clinically RB cord-010092-uftc8inx 12450 9 significant significant JJ cord-010092-uftc8inx 12450 10 ( ( -LRB- cord-010092-uftc8inx 12450 11 > > NFP cord-010092-uftc8inx 12450 12 5 5 CD cord-010092-uftc8inx 12450 13 % % NN cord-010092-uftc8inx 12450 14 ) ) -RRB- cord-010092-uftc8inx 12450 15 . . . cord-010092-uftc8inx 12451 1 Summary Summary NNP cord-010092-uftc8inx 12451 2 / / SYM cord-010092-uftc8inx 12451 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 12451 4 : : : cord-010092-uftc8inx 12452 1 We -PRON- PRP cord-010092-uftc8inx 12452 2 report report VBP cord-010092-uftc8inx 12452 3 the the DT cord-010092-uftc8inx 12452 4 production production NN cord-010092-uftc8inx 12452 5 of of IN cord-010092-uftc8inx 12452 6 alloanti alloanti NNP cord-010092-uftc8inx 12452 7 - - HYPH cord-010092-uftc8inx 12452 8 D D NNP cord-010092-uftc8inx 12452 9 in in IN cord-010092-uftc8inx 12452 10 a a DT cord-010092-uftc8inx 12452 11 SCD SCD NNP cord-010092-uftc8inx 12452 12 patient patient NN cord-010092-uftc8inx 12452 13 with with IN cord-010092-uftc8inx 12452 14 RHD*weak RHD*weak NNP cord-010092-uftc8inx 12452 15 D D NNP cord-010092-uftc8inx 12452 16 type type NN cord-010092-uftc8inx 12452 17 3 3 CD cord-010092-uftc8inx 12452 18 allele allele NN cord-010092-uftc8inx 12452 19 . . . cord-010092-uftc8inx 12453 1 Weak weak JJ cord-010092-uftc8inx 12453 2 D d NN cord-010092-uftc8inx 12453 3 type type NN cord-010092-uftc8inx 12453 4 3 3 CD cord-010092-uftc8inx 12453 5 patients patient NNS cord-010092-uftc8inx 12453 6 are be VBP cord-010092-uftc8inx 12453 7 not not RB cord-010092-uftc8inx 12453 8 considered consider VBN cord-010092-uftc8inx 12453 9 to to TO cord-010092-uftc8inx 12453 10 be be VB cord-010092-uftc8inx 12453 11 at at IN cord-010092-uftc8inx 12453 12 risk risk NN cord-010092-uftc8inx 12453 13 for for IN cord-010092-uftc8inx 12453 14 allo allo NNP cord-010092-uftc8inx 12453 15 anti anti JJ cord-010092-uftc8inx 12453 16 - - JJ cord-010092-uftc8inx 12453 17 D d JJ cord-010092-uftc8inx 12453 18 but but CC cord-010092-uftc8inx 12453 19 our -PRON- PRP$ cord-010092-uftc8inx 12453 20 results result NNS cord-010092-uftc8inx 12453 21 show show VBP cord-010092-uftc8inx 12453 22 that that IN cord-010092-uftc8inx 12453 23 there there EX cord-010092-uftc8inx 12453 24 are be VBP cord-010092-uftc8inx 12453 25 exceptions exception NNS cord-010092-uftc8inx 12453 26 and and CC cord-010092-uftc8inx 12453 27 that that IN cord-010092-uftc8inx 12453 28 these these DT cord-010092-uftc8inx 12453 29 anti anti JJ cord-010092-uftc8inx 12453 30 - - JJ cord-010092-uftc8inx 12453 31 D d JJ cord-010092-uftc8inx 12453 32 can can MD cord-010092-uftc8inx 12453 33 be be VB cord-010092-uftc8inx 12453 34 associated associate VBN cord-010092-uftc8inx 12453 35 with with IN cord-010092-uftc8inx 12453 36 clinically clinically RB cord-010092-uftc8inx 12453 37 significant significant JJ cord-010092-uftc8inx 12453 38 RBC RBC NNP cord-010092-uftc8inx 12453 39 destruction destruction NN cord-010092-uftc8inx 12453 40 . . . cord-010092-uftc8inx 12454 1 Background background NN cord-010092-uftc8inx 12454 2 : : : cord-010092-uftc8inx 12455 1 The the DT cord-010092-uftc8inx 12455 2 MNS MNS NNP cord-010092-uftc8inx 12455 3 blood blood NN cord-010092-uftc8inx 12455 4 group group NN cord-010092-uftc8inx 12455 5 system system NN cord-010092-uftc8inx 12455 6 is be VBZ cord-010092-uftc8inx 12455 7 located locate VBN cord-010092-uftc8inx 12455 8 on on IN cord-010092-uftc8inx 12455 9 Glycophorin Glycophorin NNP cord-010092-uftc8inx 12455 10 A A NNP cord-010092-uftc8inx 12455 11 ( ( -LRB- cord-010092-uftc8inx 12455 12 GPA GPA NNP cord-010092-uftc8inx 12455 13 ) ) -RRB- cord-010092-uftc8inx 12455 14 , , , cord-010092-uftc8inx 12455 15 Glycophorin Glycophorin NNP cord-010092-uftc8inx 12455 16 B B NNP cord-010092-uftc8inx 12455 17 ( ( -LRB- cord-010092-uftc8inx 12455 18 GPB GPB NNP cord-010092-uftc8inx 12455 19 ) ) -RRB- cord-010092-uftc8inx 12455 20 and and CC cord-010092-uftc8inx 12455 21 hybrid hybrid JJ cord-010092-uftc8inx 12455 22 glycophorins glycophorin NNS cord-010092-uftc8inx 12455 23 on on IN cord-010092-uftc8inx 12455 24 the the DT cord-010092-uftc8inx 12455 25 surface surface NN cord-010092-uftc8inx 12455 26 of of IN cord-010092-uftc8inx 12455 27 the the DT cord-010092-uftc8inx 12455 28 red red JJ cord-010092-uftc8inx 12455 29 blood blood NN cord-010092-uftc8inx 12455 30 cell cell NN cord-010092-uftc8inx 12455 31 ( ( -LRB- cord-010092-uftc8inx 12455 32 RBC RBC NNP cord-010092-uftc8inx 12455 33 ) ) -RRB- cord-010092-uftc8inx 12455 34 . . . cord-010092-uftc8inx 12456 1 These these DT cord-010092-uftc8inx 12456 2 glycoproteins glycoprotein NNS cord-010092-uftc8inx 12456 3 are be VBP cord-010092-uftc8inx 12456 4 involved involve VBN cord-010092-uftc8inx 12456 5 in in IN cord-010092-uftc8inx 12456 6 complex complex JJ cord-010092-uftc8inx 12456 7 structures structure NNS cord-010092-uftc8inx 12456 8 interacting interact VBG cord-010092-uftc8inx 12456 9 with with IN cord-010092-uftc8inx 12456 10 other other JJ cord-010092-uftc8inx 12456 11 RBC RBC NNP cord-010092-uftc8inx 12456 12 surface surface NN cord-010092-uftc8inx 12456 13 proteins protein NNS cord-010092-uftc8inx 12456 14 including include VBG cord-010092-uftc8inx 12456 15 the the DT cord-010092-uftc8inx 12456 16 Band Band NNP cord-010092-uftc8inx 12456 17 3 3 CD cord-010092-uftc8inx 12456 18 / / SYM cord-010092-uftc8inx 12456 19 Diego Diego NNP cord-010092-uftc8inx 12456 20 protein protein NN cord-010092-uftc8inx 12456 21 . . . cord-010092-uftc8inx 12457 1 The the DT cord-010092-uftc8inx 12457 2 glycophorins glycophorin NNS cord-010092-uftc8inx 12457 3 are be VBP cord-010092-uftc8inx 12457 4 heavily heavily RB cord-010092-uftc8inx 12457 5 glycosylated glycosylate VBN cord-010092-uftc8inx 12457 6 and and CC cord-010092-uftc8inx 12457 7 contains contain VBZ cord-010092-uftc8inx 12457 8 multiple multiple JJ cord-010092-uftc8inx 12457 9 clinically clinically RB cord-010092-uftc8inx 12457 10 significant significant JJ cord-010092-uftc8inx 12457 11 blood blood NN cord-010092-uftc8inx 12457 12 group group NN cord-010092-uftc8inx 12457 13 antigens antigen NNS cord-010092-uftc8inx 12457 14 . . . cord-010092-uftc8inx 12458 1 It -PRON- PRP cord-010092-uftc8inx 12458 2 has have VBZ cord-010092-uftc8inx 12458 3 proved prove VBN cord-010092-uftc8inx 12458 4 difficult difficult JJ cord-010092-uftc8inx 12458 5 to to TO cord-010092-uftc8inx 12458 6 model model VB cord-010092-uftc8inx 12458 7 the the DT cord-010092-uftc8inx 12458 8 GPA GPA NNP cord-010092-uftc8inx 12458 9 extracellular extracellular JJ cord-010092-uftc8inx 12458 10 structure structure NN cord-010092-uftc8inx 12458 11 due due IN cord-010092-uftc8inx 12458 12 to to IN cord-010092-uftc8inx 12458 13 its -PRON- PRP$ cord-010092-uftc8inx 12458 14 heavy heavy JJ cord-010092-uftc8inx 12458 15 glycosylation glycosylation NN cord-010092-uftc8inx 12458 16 , , , cord-010092-uftc8inx 12458 17 and and CC cord-010092-uftc8inx 12458 18 lack lack NN cord-010092-uftc8inx 12458 19 of of IN cord-010092-uftc8inx 12458 20 homology homology NN cord-010092-uftc8inx 12458 21 with with IN cord-010092-uftc8inx 12458 22 existing exist VBG cord-010092-uftc8inx 12458 23 modelled model VBN cord-010092-uftc8inx 12458 24 proteins protein NNS cord-010092-uftc8inx 12458 25 . . . cord-010092-uftc8inx 12459 1 Aims aim VBZ cord-010092-uftc8inx 12459 2 : : : cord-010092-uftc8inx 12459 3 To to TO cord-010092-uftc8inx 12459 4 develop develop VB cord-010092-uftc8inx 12459 5 an an DT cord-010092-uftc8inx 12459 6 in in IN cord-010092-uftc8inx 12459 7 silico silico NN cord-010092-uftc8inx 12459 8 model model NN cord-010092-uftc8inx 12459 9 of of IN cord-010092-uftc8inx 12459 10 GPA GPA NNP cord-010092-uftc8inx 12459 11 as as IN cord-010092-uftc8inx 12459 12 a a DT cord-010092-uftc8inx 12459 13 basis basis NN cord-010092-uftc8inx 12459 14 for for IN cord-010092-uftc8inx 12459 15 improved improved JJ cord-010092-uftc8inx 12459 16 predictions prediction NNS cord-010092-uftc8inx 12459 17 of of IN cord-010092-uftc8inx 12459 18 structure structure NN cord-010092-uftc8inx 12459 19 function function NN cord-010092-uftc8inx 12459 20 relationships relationship NNS cord-010092-uftc8inx 12459 21 Methods method NNS cord-010092-uftc8inx 12459 22 : : : cord-010092-uftc8inx 12460 1 Prediction prediction NN cord-010092-uftc8inx 12460 2 of of IN cord-010092-uftc8inx 12460 3 secondary secondary JJ cord-010092-uftc8inx 12460 4 structure structure NN cord-010092-uftc8inx 12460 5 and and CC cord-010092-uftc8inx 12460 6 disorder disorder NN cord-010092-uftc8inx 12460 7 : : : cord-010092-uftc8inx 12460 8 1.1 1.1 CD cord-010092-uftc8inx 12460 9 . . . cord-010092-uftc8inx 12461 1 PredictProtein PredictProtein NNP cord-010092-uftc8inx 12461 2 ( ( -LRB- cord-010092-uftc8inx 12461 3 https://predictprotein.org https://predictprotein.org NFP cord-010092-uftc8inx 12461 4 ) ) -RRB- cord-010092-uftc8inx 12461 5 ; ; : cord-010092-uftc8inx 12461 6 1.2 1.2 CD cord-010092-uftc8inx 12461 7 . . . cord-010092-uftc8inx 12462 1 Spider2 Spider2 NNP cord-010092-uftc8inx 12463 1 ( ( -LRB- cord-010092-uftc8inx 12463 2 http://sparks-lab.org/server/SPIDER2/ http://sparks-lab.org/server/SPIDER2/ NNP cord-010092-uftc8inx 12463 3 ) ) -RRB- cord-010092-uftc8inx 12463 4 ; ; : cord-010092-uftc8inx 12463 5 1.3 1.3 CD cord-010092-uftc8inx 12463 6 . . . cord-010092-uftc8inx 12464 1 DSC DSC NNP cord-010092-uftc8inx 12464 2 ( ( -LRB- cord-010092-uftc8inx 12464 3 Discrimination Discrimination NNP cord-010092-uftc8inx 12464 4 of of IN cord-010092-uftc8inx 12464 5 Protein Protein NNP cord-010092-uftc8inx 12464 6 Secondary Secondary NNP cord-010092-uftc8inx 12464 7 Structure Structure NNP cord-010092-uftc8inx 12464 8 Class Class NNP cord-010092-uftc8inx 12464 9 ) ) -RRB- cord-010092-uftc8inx 12464 10 : : : cord-010092-uftc8inx 12465 1 Using use VBG cord-010092-uftc8inx 12465 2 an an DT cord-010092-uftc8inx 12465 3 in in IN cord-010092-uftc8inx 12465 4 - - HYPH cord-010092-uftc8inx 12465 5 house house NN cord-010092-uftc8inx 12465 6 implementation implementation NN cord-010092-uftc8inx 12465 7 ; ; : cord-010092-uftc8inx 12465 8 1.4 1.4 CD cord-010092-uftc8inx 12465 9 . . . cord-010092-uftc8inx 12465 10 Jpred4 Jpred4 NNP cord-010092-uftc8inx 12466 1 ( ( -LRB- cord-010092-uftc8inx 12466 2 http://www.compbio.dundee.ac.uk/jpred4/ http://www.compbio.dundee.ac.uk/jpred4/ NN cord-010092-uftc8inx 12466 3 ) ) -RRB- cord-010092-uftc8inx 12466 4 ; ; : cord-010092-uftc8inx 12467 1 1.5 1.5 CD cord-010092-uftc8inx 12467 2 . . . cord-010092-uftc8inx 12468 1 RaptorX RaptorX NNS cord-010092-uftc8inx 12468 2 ( ( -LRB- cord-010092-uftc8inx 12468 3 http://raptorx.uchicago.edu http://raptorx.uchicago.edu NN cord-010092-uftc8inx 12468 4 ) ) -RRB- cord-010092-uftc8inx 12468 5 . . . cord-010092-uftc8inx 12469 1 Prediction prediction NN cord-010092-uftc8inx 12469 2 of of IN cord-010092-uftc8inx 12469 3 secondary secondary JJ cord-010092-uftc8inx 12469 4 structure structure NN cord-010092-uftc8inx 12469 5 : : : cord-010092-uftc8inx 12469 6 2.1 2.1 CD cord-010092-uftc8inx 12469 7 . . . cord-010092-uftc8inx 12470 1 Robetta Robetta NNP cord-010092-uftc8inx 12470 2 ( ( -LRB- cord-010092-uftc8inx 12470 3 http://robetta.bakerlab.org/submit http://robetta.bakerlab.org/submit ADD cord-010092-uftc8inx 12470 4 . . . cord-010092-uftc8inx 12471 1 jsp jsp NNP cord-010092-uftc8inx 12471 2 ) ) -RRB- cord-010092-uftc8inx 12471 3 ; ; : cord-010092-uftc8inx 12471 4 2.2 2.2 CD cord-010092-uftc8inx 12471 5 . . . cord-010092-uftc8inx 12472 1 FALCON FALCON NNP cord-010092-uftc8inx 12472 2 ( ( -LRB- cord-010092-uftc8inx 12472 3 http://protein.ict.ac.cn/TreeThreader/ http://protein.ict.ac.cn/TreeThreader/ NNP cord-010092-uftc8inx 12472 4 ) ) -RRB- cord-010092-uftc8inx 12472 5 ; ; : cord-010092-uftc8inx 12472 6 2.3 2.3 CD cord-010092-uftc8inx 12472 7 . . . cord-010092-uftc8inx 12473 1 iTasser iTasser NNP cord-010092-uftc8inx 12473 2 ( ( -LRB- cord-010092-uftc8inx 12473 3 https://zha https://zha NNP cord-010092-uftc8inx 12473 4 nglab.ccmb.med.umich.edu/I-TASSER/ nglab.ccmb.med.umich.edu/i-tasser/ LS cord-010092-uftc8inx 12473 5 ) ) -RRB- cord-010092-uftc8inx 12474 1 Threading threading NN cord-010092-uftc8inx 12474 2 methods method NNS cord-010092-uftc8inx 12474 3 to to TO cord-010092-uftc8inx 12474 4 evaluate evaluate VB cord-010092-uftc8inx 12474 5 the the DT cord-010092-uftc8inx 12474 6 quality quality NN cord-010092-uftc8inx 12474 7 of of IN cord-010092-uftc8inx 12474 8 protein protein NN cord-010092-uftc8inx 12474 9 structures structure NNS cord-010092-uftc8inx 12474 10 : : : cord-010092-uftc8inx 12474 11 3.1 3.1 CD cord-010092-uftc8inx 12474 12 . . . cord-010092-uftc8inx 12474 13 Verify3D Verify3D NNP cord-010092-uftc8inx 12474 14 ( ( -LRB- cord-010092-uftc8inx 12474 15 http://servicesn.mbi.ucla.edu/Verify3D/ http://servicesn.mbi.ucla.edu/Verify3D/ NNP cord-010092-uftc8inx 12474 16 ) ) -RRB- cord-010092-uftc8inx 12474 17 ; ; : cord-010092-uftc8inx 12474 18 3.2 3.2 CD cord-010092-uftc8inx 12474 19 . . . cord-010092-uftc8inx 12474 20 Prosa Prosa NNP cord-010092-uftc8inx 12475 1 ( ( -LRB- cord-010092-uftc8inx 12475 2 https://prosa.services.came.sb https://prosa.services.came.sb NNP cord-010092-uftc8inx 12475 3 g.ac.at/prosa.php g.ac.at/prosa.php NNP cord-010092-uftc8inx 12475 4 ) ) -RRB- cord-010092-uftc8inx 12475 5 Protein Protein NNP cord-010092-uftc8inx 12475 6 - - HYPH cord-010092-uftc8inx 12475 7 Protein Protein NNP cord-010092-uftc8inx 12475 8 Docking Docking NNP cord-010092-uftc8inx 12475 9 : : : cord-010092-uftc8inx 12475 10 4.1 4.1 CD cord-010092-uftc8inx 12475 11 . . . cord-010092-uftc8inx 12476 1 GRAMM GRAMM NNP cord-010092-uftc8inx 12476 2 - - HYPH cord-010092-uftc8inx 12476 3 X X NNP cord-010092-uftc8inx 12476 4 Protein Protein NNP cord-010092-uftc8inx 12476 5 - - HYPH cord-010092-uftc8inx 12476 6 Protein Protein NNP cord-010092-uftc8inx 12476 7 Docking Docking NNP cord-010092-uftc8inx 12476 8 Web web NN cord-010092-uftc8inx 12476 9 Server server NN cord-010092-uftc8inx 12476 10 ( ( -LRB- cord-010092-uftc8inx 12476 11 http://vakser.compbio.ku.edu/resources/gramm/grammx/ http://vakser.compbio.ku.edu/resources/gramm/grammx/ NNP cord-010092-uftc8inx 12476 12 ) ) -RRB- cord-010092-uftc8inx 12476 13 ; ; : cord-010092-uftc8inx 12476 14 4.2 4.2 CD cord-010092-uftc8inx 12476 15 . . . cord-010092-uftc8inx 12477 1 GRAMM GRAMM NNP cord-010092-uftc8inx 12477 2 ( ( -LRB- cord-010092-uftc8inx 12477 3 http://va http://va IN cord-010092-uftc8inx 12477 4 kser.compbio.ku.edu/main/resources_gramm1.03.php kser.compbio.ku.edu/main/resources_gramm1.03.php NN cord-010092-uftc8inx 12477 5 ) ) -RRB- cord-010092-uftc8inx 12477 6 Results result NNS cord-010092-uftc8inx 12477 7 : : : cord-010092-uftc8inx 12477 8 Using use VBG cord-010092-uftc8inx 12477 9 in in IN cord-010092-uftc8inx 12477 10 silico silico NN cord-010092-uftc8inx 12477 11 modelling modelling NN cord-010092-uftc8inx 12477 12 we -PRON- PRP cord-010092-uftc8inx 12477 13 derived derive VBD cord-010092-uftc8inx 12477 14 a a DT cord-010092-uftc8inx 12477 15 stable stable JJ cord-010092-uftc8inx 12477 16 tertiary tertiary JJ cord-010092-uftc8inx 12477 17 glycosylated glycosylated JJ cord-010092-uftc8inx 12477 18 structure structure NN cord-010092-uftc8inx 12477 19 for for IN cord-010092-uftc8inx 12477 20 GPA GPA NNP cord-010092-uftc8inx 12477 21 both both CC cord-010092-uftc8inx 12477 22 as as IN cord-010092-uftc8inx 12477 23 an an DT cord-010092-uftc8inx 12477 24 individual individual JJ cord-010092-uftc8inx 12477 25 protein protein NN cord-010092-uftc8inx 12477 26 and and CC cord-010092-uftc8inx 12477 27 a a DT cord-010092-uftc8inx 12477 28 homodimer homodimer NN cord-010092-uftc8inx 12477 29 . . . cord-010092-uftc8inx 12478 1 The the DT cord-010092-uftc8inx 12478 2 hybrid hybrid JJ cord-010092-uftc8inx 12478 3 glycophorin glycophorin NN cord-010092-uftc8inx 12478 4 Background background NN cord-010092-uftc8inx 12478 5 : : : cord-010092-uftc8inx 12479 1 Non non JJ cord-010092-uftc8inx 12479 2 - - JJ cord-010092-uftc8inx 12479 3 invasive invasive JJ cord-010092-uftc8inx 12479 4 prenatal prenatal JJ cord-010092-uftc8inx 12479 5 testing testing NN cord-010092-uftc8inx 12479 6 of of IN cord-010092-uftc8inx 12479 7 fetal fetal JJ cord-010092-uftc8inx 12479 8 antigen antigen NN cord-010092-uftc8inx 12479 9 using use VBG cord-010092-uftc8inx 12479 10 cell cell NN cord-010092-uftc8inx 12479 11 - - HYPH cord-010092-uftc8inx 12479 12 free free JJ cord-010092-uftc8inx 12479 13 fetal fetal NN cord-010092-uftc8inx 12479 14 ( ( -LRB- cord-010092-uftc8inx 12479 15 cff cff NNP cord-010092-uftc8inx 12479 16 ) ) -RRB- cord-010092-uftc8inx 12479 17 DNA dna NN cord-010092-uftc8inx 12479 18 from from IN cord-010092-uftc8inx 12479 19 maternal maternal JJ cord-010092-uftc8inx 12479 20 plasma plasma NN cord-010092-uftc8inx 12479 21 of of IN cord-010092-uftc8inx 12479 22 immunized immunized JJ cord-010092-uftc8inx 12479 23 women woman NNS cord-010092-uftc8inx 12479 24 is be VBZ cord-010092-uftc8inx 12479 25 widely widely RB cord-010092-uftc8inx 12479 26 implemented implement VBN cord-010092-uftc8inx 12479 27 into into IN cord-010092-uftc8inx 12479 28 clinical clinical JJ cord-010092-uftc8inx 12479 29 routine routine NN cord-010092-uftc8inx 12479 30 but but CC cord-010092-uftc8inx 12479 31 the the DT cord-010092-uftc8inx 12479 32 sensitivity sensitivity NN cord-010092-uftc8inx 12479 33 and and CC cord-010092-uftc8inx 12479 34 specificity specificity NN cord-010092-uftc8inx 12479 35 of of IN cord-010092-uftc8inx 12479 36 the the DT cord-010092-uftc8inx 12479 37 method method NN cord-010092-uftc8inx 12479 38 , , , cord-010092-uftc8inx 12479 39 especially especially RB cord-010092-uftc8inx 12479 40 for for IN cord-010092-uftc8inx 12479 41 genotyping genotype VBG cord-010092-uftc8inx 12479 42 antigens antigen NNS cord-010092-uftc8inx 12479 43 encoded encode VBN cord-010092-uftc8inx 12479 44 by by IN cord-010092-uftc8inx 12479 45 single single JJ cord-010092-uftc8inx 12479 46 nucleotide nucleotide JJ cord-010092-uftc8inx 12479 47 polymorphisms polymorphism NNS cord-010092-uftc8inx 12479 48 such such JJ cord-010092-uftc8inx 12479 49 as as IN cord-010092-uftc8inx 12479 50 K K NNP cord-010092-uftc8inx 12479 51 antigen antigen NNP cord-010092-uftc8inx 12479 52 , , , cord-010092-uftc8inx 12479 53 is be VBZ cord-010092-uftc8inx 12479 54 limited limit VBN cord-010092-uftc8inx 12479 55 by by IN cord-010092-uftc8inx 12479 56 low low JJ cord-010092-uftc8inx 12479 57 proportion proportion NN cord-010092-uftc8inx 12479 58 of of IN cord-010092-uftc8inx 12479 59 cffDNA cffdna NN cord-010092-uftc8inx 12479 60 in in IN cord-010092-uftc8inx 12479 61 maternal maternal JJ cord-010092-uftc8inx 12479 62 plasma plasma NN cord-010092-uftc8inx 12479 63 DNA dna NN cord-010092-uftc8inx 12479 64 . . . cord-010092-uftc8inx 12480 1 According accord VBG cord-010092-uftc8inx 12480 2 to to IN cord-010092-uftc8inx 12480 3 literature literature NN cord-010092-uftc8inx 12480 4 reports report VBZ cord-010092-uftc8inx 12480 5 detection detection NN cord-010092-uftc8inx 12480 6 of of IN cord-010092-uftc8inx 12480 7 circulating circulate VBG cord-010092-uftc8inx 12480 8 tumour tumour NN cord-010092-uftc8inx 12480 9 ( ( -LRB- cord-010092-uftc8inx 12480 10 ct)DNA ct)DNA NNP cord-010092-uftc8inx 12480 11 can can MD cord-010092-uftc8inx 12480 12 be be VB cord-010092-uftc8inx 12480 13 improved improve VBN cord-010092-uftc8inx 12480 14 by by IN cord-010092-uftc8inx 12480 15 selection selection NN cord-010092-uftc8inx 12480 16 of of IN cord-010092-uftc8inx 12480 17 short short JJ cord-010092-uftc8inx 12480 18 ctDNA ctdna NN cord-010092-uftc8inx 12480 19 fragments fragment NNS cord-010092-uftc8inx 12480 20 using use VBG cord-010092-uftc8inx 12480 21 automated automate VBN cord-010092-uftc8inx 12480 22 electrophoresis electrophoresis NN cord-010092-uftc8inx 12480 23 methods method NNS cord-010092-uftc8inx 12480 24 . . . cord-010092-uftc8inx 12481 1 Aims aim VBZ cord-010092-uftc8inx 12481 2 : : : cord-010092-uftc8inx 12482 1 The the DT cord-010092-uftc8inx 12482 2 aim aim NN cord-010092-uftc8inx 12482 3 was be VBD cord-010092-uftc8inx 12482 4 to to TO cord-010092-uftc8inx 12482 5 assess assess VB cord-010092-uftc8inx 12482 6 the the DT cord-010092-uftc8inx 12482 7 feasibility feasibility NN cord-010092-uftc8inx 12482 8 for for IN cord-010092-uftc8inx 12482 9 enrichment enrichment NN cord-010092-uftc8inx 12482 10 of of IN cord-010092-uftc8inx 12482 11 cffDNA cffdna JJ cord-010092-uftc8inx 12482 12 fraction fraction NN cord-010092-uftc8inx 12482 13 in in IN cord-010092-uftc8inx 12482 14 maternal maternal JJ cord-010092-uftc8inx 12482 15 plasma plasma NN cord-010092-uftc8inx 12482 16 DNA dna NN cord-010092-uftc8inx 12482 17 by by IN cord-010092-uftc8inx 12482 18 size size NN cord-010092-uftc8inx 12482 19 selection selection NN cord-010092-uftc8inx 12482 20 using use VBG cord-010092-uftc8inx 12482 21 the the DT cord-010092-uftc8inx 12482 22 Pippin Pippin NNP cord-010092-uftc8inx 12482 23 Prep Prep NNP cord-010092-uftc8inx 12482 24 gel gel NN cord-010092-uftc8inx 12482 25 selection selection NN cord-010092-uftc8inx 12482 26 system system NN cord-010092-uftc8inx 12482 27 . . . cord-010092-uftc8inx 12483 1 Methods method NNS cord-010092-uftc8inx 12483 2 : : : cord-010092-uftc8inx 12483 3 Plasma plasma NN cord-010092-uftc8inx 12483 4 DNA dna NN cord-010092-uftc8inx 12483 5 isolated isolate VBN cord-010092-uftc8inx 12483 6 using use VBG cord-010092-uftc8inx 12483 7 easyMag easyMag NNP cord-010092-uftc8inx 12483 8 ( ( -LRB- cord-010092-uftc8inx 12483 9 Biomerieux Biomerieux NNP cord-010092-uftc8inx 12483 10 ) ) -RRB- cord-010092-uftc8inx 12483 11 from from IN cord-010092-uftc8inx 12483 12 RhD rhd NN cord-010092-uftc8inx 12483 13 negative negative JJ cord-010092-uftc8inx 12483 14 and and CC cord-010092-uftc8inx 12483 15 K k NN cord-010092-uftc8inx 12483 16 - - HYPH cord-010092-uftc8inx 12483 17 negative negative JJ cord-010092-uftc8inx 12483 18 pregnant pregnant JJ cord-010092-uftc8inx 12483 19 women woman NNS cord-010092-uftc8inx 12484 1 ( ( -LRB- cord-010092-uftc8inx 12484 2 n n NN cord-010092-uftc8inx 12484 3 = = SYM cord-010092-uftc8inx 12484 4 10 10 CD cord-010092-uftc8inx 12484 5 ) ) -RRB- cord-010092-uftc8inx 12484 6 carrying carry VBG cord-010092-uftc8inx 12484 7 fetuses fetus NNS cord-010092-uftc8inx 12484 8 with with IN cord-010092-uftc8inx 12484 9 known know VBN cord-010092-uftc8inx 12484 10 genotype genotype NN cord-010092-uftc8inx 12484 11 was be VBD cord-010092-uftc8inx 12484 12 loaded load VBN cord-010092-uftc8inx 12484 13 into into IN cord-010092-uftc8inx 12484 14 3 3 CD cord-010092-uftc8inx 12484 15 % % NN cord-010092-uftc8inx 12484 16 agarose agarose NN cord-010092-uftc8inx 12484 17 gel gel NN cord-010092-uftc8inx 12484 18 casette casette NN cord-010092-uftc8inx 12484 19 ( ( -LRB- cord-010092-uftc8inx 12484 20 3 3 CD cord-010092-uftc8inx 12484 21 % % NN cord-010092-uftc8inx 12484 22 DF DF NNP cord-010092-uftc8inx 12484 23 Marker Marker NNP cord-010092-uftc8inx 12484 24 Q3 Q3 NNP cord-010092-uftc8inx 12484 25 , , , cord-010092-uftc8inx 12484 26 Sage Sage NNP cord-010092-uftc8inx 12484 27 Bioscience Bioscience NNP cord-010092-uftc8inx 12484 28 ) ) -RRB- cord-010092-uftc8inx 12484 29 and and CC cord-010092-uftc8inx 12484 30 size size NN cord-010092-uftc8inx 12484 31 selection selection NN cord-010092-uftc8inx 12484 32 of of IN cord-010092-uftc8inx 12484 33 fraction fraction NN cord-010092-uftc8inx 12484 34 was be VBD cord-010092-uftc8inx 12484 35 performed perform VBN cord-010092-uftc8inx 12484 36 on on IN cord-010092-uftc8inx 12484 37 a a DT cord-010092-uftc8inx 12484 38 Blue Blue NNP cord-010092-uftc8inx 12484 39 Pippin Pippin NNP cord-010092-uftc8inx 12484 40 TM TM NNP cord-010092-uftc8inx 12484 41 ( ( -LRB- cord-010092-uftc8inx 12484 42 Sage Sage NNP cord-010092-uftc8inx 12484 43 Bioscience Bioscience NNP cord-010092-uftc8inx 12484 44 ) ) -RRB- cord-010092-uftc8inx 12484 45 with with IN cord-010092-uftc8inx 12484 46 the the DT cord-010092-uftc8inx 12484 47 elution elution NN cord-010092-uftc8inx 12484 48 from from IN cord-010092-uftc8inx 12484 49 45 45 CD cord-010092-uftc8inx 12484 50 min min NN cord-010092-uftc8inx 12484 51 to to IN cord-010092-uftc8inx 12484 52 2 2 CD cord-010092-uftc8inx 12484 53 h h NN cord-010092-uftc8inx 12484 54 30 30 CD cord-010092-uftc8inx 12484 55 min min NN cord-010092-uftc8inx 12484 56 of of IN cord-010092-uftc8inx 12484 57 electrophoresis electrophoresis NN cord-010092-uftc8inx 12484 58 . . . cord-010092-uftc8inx 12485 1 Results result NNS cord-010092-uftc8inx 12485 2 for for IN cord-010092-uftc8inx 12485 3 real real JJ cord-010092-uftc8inx 12485 4 - - HYPH cord-010092-uftc8inx 12485 5 time time NN cord-010092-uftc8inx 12485 6 PCR PCR NNP cord-010092-uftc8inx 12485 7 detection detection NN cord-010092-uftc8inx 12485 8 of of IN cord-010092-uftc8inx 12485 9 fetal fetal JJ cord-010092-uftc8inx 12485 10 RHD RHD NNP cord-010092-uftc8inx 12485 11 , , , cord-010092-uftc8inx 12485 12 KEL*1 KEL*1 NNP cord-010092-uftc8inx 12485 13 and and CC cord-010092-uftc8inx 12485 14 CCR5 CCR5 NNP cord-010092-uftc8inx 12485 15 ( ( -LRB- cord-010092-uftc8inx 12485 16 as as IN cord-010092-uftc8inx 12485 17 a a DT cord-010092-uftc8inx 12485 18 marker marker NN cord-010092-uftc8inx 12485 19 of of IN cord-010092-uftc8inx 12485 20 total total JJ cord-010092-uftc8inx 12485 21 plasma plasma NN cord-010092-uftc8inx 12485 22 DNA dna NN cord-010092-uftc8inx 12485 23 ) ) -RRB- cord-010092-uftc8inx 12485 24 in in IN cord-010092-uftc8inx 12485 25 DNA dna NN cord-010092-uftc8inx 12485 26 fraction fraction NN cord-010092-uftc8inx 12485 27 after after IN cord-010092-uftc8inx 12485 28 gel gel NN cord-010092-uftc8inx 12485 29 selection selection NN cord-010092-uftc8inx 12485 30 were be VBD cord-010092-uftc8inx 12485 31 compared compare VBN cord-010092-uftc8inx 12485 32 to to IN cord-010092-uftc8inx 12485 33 results result NNS cord-010092-uftc8inx 12485 34 obtained obtain VBN cord-010092-uftc8inx 12485 35 from from IN cord-010092-uftc8inx 12485 36 non non JJ cord-010092-uftc8inx 12485 37 - - JJ cord-010092-uftc8inx 12485 38 processed processed JJ cord-010092-uftc8inx 12485 39 plasma plasma NN cord-010092-uftc8inx 12485 40 DNA dna NN cord-010092-uftc8inx 12485 41 . . . cord-010092-uftc8inx 12486 1 Results result NNS cord-010092-uftc8inx 12486 2 : : : cord-010092-uftc8inx 12487 1 The the DT cord-010092-uftc8inx 12487 2 total total JJ cord-010092-uftc8inx 12487 3 DNA dna NN cord-010092-uftc8inx 12487 4 level level NN cord-010092-uftc8inx 12487 5 ( ( -LRB- cord-010092-uftc8inx 12487 6 measured measure VBN cord-010092-uftc8inx 12487 7 by by IN cord-010092-uftc8inx 12487 8 CCR5 CCR5 NNP cord-010092-uftc8inx 12487 9 ) ) -RRB- cord-010092-uftc8inx 12487 10 was be VBD cord-010092-uftc8inx 12487 11 significantly significantly RB cord-010092-uftc8inx 12487 12 lower low JJR cord-010092-uftc8inx 12487 13 in in IN cord-010092-uftc8inx 12487 14 DNA dna NN cord-010092-uftc8inx 12487 15 samples sample NNS cord-010092-uftc8inx 12487 16 tested test VBN cord-010092-uftc8inx 12487 17 after after IN cord-010092-uftc8inx 12487 18 gel gel NN cord-010092-uftc8inx 12487 19 selection selection NN cord-010092-uftc8inx 12487 20 ( ( -LRB- cord-010092-uftc8inx 12487 21 from from IN cord-010092-uftc8inx 12487 22 8.4 8.4 CD cord-010092-uftc8inx 12487 23 to to IN cord-010092-uftc8inx 12487 24 25.9geq 25.9geq CD cord-010092-uftc8inx 12487 25 / / SYM cord-010092-uftc8inx 12487 26 PCR PCR NNP cord-010092-uftc8inx 12487 27 ) ) -RRB- cord-010092-uftc8inx 12487 28 versus versus IN cord-010092-uftc8inx 12487 29 the the DT cord-010092-uftc8inx 12487 30 level level NN cord-010092-uftc8inx 12487 31 obtained obtain VBN cord-010092-uftc8inx 12487 32 from from IN cord-010092-uftc8inx 12487 33 non non JJ cord-010092-uftc8inx 12487 34 - - JJ cord-010092-uftc8inx 12487 35 processed processed JJ cord-010092-uftc8inx 12487 36 plasma plasma NN cord-010092-uftc8inx 12487 37 DNA dna NN cord-010092-uftc8inx 12487 38 ( ( -LRB- cord-010092-uftc8inx 12487 39 from from IN cord-010092-uftc8inx 12487 40 130 130 CD cord-010092-uftc8inx 12487 41 to to IN cord-010092-uftc8inx 12487 42 133geq 133geq CD cord-010092-uftc8inx 12487 43 / / SYM cord-010092-uftc8inx 12487 44 PCR PCR NNP cord-010092-uftc8inx 12487 45 ) ) -RRB- cord-010092-uftc8inx 12487 46 . . . cord-010092-uftc8inx 12488 1 The the DT cord-010092-uftc8inx 12488 2 results result NNS cord-010092-uftc8inx 12488 3 for for IN cord-010092-uftc8inx 12488 4 fetal fetal JJ cord-010092-uftc8inx 12488 5 fraction fraction NN cord-010092-uftc8inx 12488 6 ( ( -LRB- cord-010092-uftc8inx 12488 7 measured measure VBN cord-010092-uftc8inx 12488 8 by by IN cord-010092-uftc8inx 12488 9 RHD RHD NNP cord-010092-uftc8inx 12488 10 ) ) -RRB- cord-010092-uftc8inx 12488 11 from from IN cord-010092-uftc8inx 12488 12 DNA dna NN cord-010092-uftc8inx 12488 13 samples sample NNS cord-010092-uftc8inx 12488 14 of of IN cord-010092-uftc8inx 12488 15 RhD rhd NN cord-010092-uftc8inx 12488 16 - - HYPH cord-010092-uftc8inx 12488 17 negative negative JJ cord-010092-uftc8inx 12488 18 pregnant pregnant JJ cord-010092-uftc8inx 12488 19 women woman NNS cord-010092-uftc8inx 12488 20 carrying carry VBG cord-010092-uftc8inx 12488 21 RHD RHD NNP cord-010092-uftc8inx 12488 22 positive positive JJ cord-010092-uftc8inx 12488 23 fetus fetus NN cord-010092-uftc8inx 12488 24 tested test VBN cord-010092-uftc8inx 12488 25 after after IN cord-010092-uftc8inx 12488 26 gel gel NN cord-010092-uftc8inx 12488 27 selection selection NN cord-010092-uftc8inx 12488 28 were be VBD cord-010092-uftc8inx 12488 29 from from IN cord-010092-uftc8inx 12488 30 1,5 1,5 CD cord-010092-uftc8inx 12488 31 to to IN cord-010092-uftc8inx 12488 32 6.6geq 6.6geq CD cord-010092-uftc8inx 12488 33 / / SYM cord-010092-uftc8inx 12488 34 PCR PCR NNP cord-010092-uftc8inx 12488 35 versus versus IN cord-010092-uftc8inx 12488 36 10.8 10.8 CD cord-010092-uftc8inx 12488 37 - - HYPH cord-010092-uftc8inx 12488 38 11.2geq 11.2geq CD cord-010092-uftc8inx 12488 39 / / SYM cord-010092-uftc8inx 12488 40 PCR PCR NNP cord-010092-uftc8inx 12488 41 for for IN cord-010092-uftc8inx 12488 42 non non JJ cord-010092-uftc8inx 12488 43 - - JJ cord-010092-uftc8inx 12488 44 processed processed JJ cord-010092-uftc8inx 12488 45 plasma plasma NN cord-010092-uftc8inx 12488 46 DNA dna NN cord-010092-uftc8inx 12488 47 . . . cord-010092-uftc8inx 12489 1 Results result NNS cord-010092-uftc8inx 12489 2 for for IN cord-010092-uftc8inx 12489 3 KEL*1 kel*1 NN cord-010092-uftc8inx 12489 4 detection detection NN cord-010092-uftc8inx 12489 5 in in IN cord-010092-uftc8inx 12489 6 plasma plasma NN cord-010092-uftc8inx 12489 7 DNA dna NN cord-010092-uftc8inx 12489 8 from from IN cord-010092-uftc8inx 12489 9 K k NN cord-010092-uftc8inx 12489 10 - - HYPH cord-010092-uftc8inx 12489 11 negative negative JJ cord-010092-uftc8inx 12489 12 pregnant pregnant JJ cord-010092-uftc8inx 12489 13 women woman NNS cord-010092-uftc8inx 12489 14 carrying carry VBG cord-010092-uftc8inx 12489 15 K k NN cord-010092-uftc8inx 12489 16 - - HYPH cord-010092-uftc8inx 12489 17 negative negative JJ cord-010092-uftc8inx 12489 18 fetus fetus NN cord-010092-uftc8inx 12489 19 were be VBD cord-010092-uftc8inx 12489 20 KEL*1-negative kel*1-negative JJ cord-010092-uftc8inx 12489 21 in in IN cord-010092-uftc8inx 12489 22 DNA dna NN cord-010092-uftc8inx 12489 23 samples sample NNS cord-010092-uftc8inx 12489 24 tested test VBN cord-010092-uftc8inx 12489 25 after after IN cord-010092-uftc8inx 12489 26 gel gel NN cord-010092-uftc8inx 12489 27 selection selection NN cord-010092-uftc8inx 12489 28 comparing compare VBG cord-010092-uftc8inx 12489 29 to to IN cord-010092-uftc8inx 12489 30 nonprocessed nonprocesse VBN cord-010092-uftc8inx 12489 31 DNA dna NN cord-010092-uftc8inx 12489 32 samples sample NNS cord-010092-uftc8inx 12489 33 were be VBD cord-010092-uftc8inx 12489 34 false false JJ cord-010092-uftc8inx 12489 35 KEL*1 kel*1 CD cord-010092-uftc8inx 12489 36 positive positive JJ cord-010092-uftc8inx 12489 37 amplification amplification NN cord-010092-uftc8inx 12489 38 was be VBD cord-010092-uftc8inx 12489 39 observed observe VBN cord-010092-uftc8inx 12489 40 . . . cord-010092-uftc8inx 12490 1 However however RB cord-010092-uftc8inx 12490 2 , , , cord-010092-uftc8inx 12490 3 KEL*1 kel*1 NN cord-010092-uftc8inx 12490 4 detection detection NN cord-010092-uftc8inx 12490 5 in in IN cord-010092-uftc8inx 12490 6 plasma plasma NN cord-010092-uftc8inx 12490 7 DNA dna NN cord-010092-uftc8inx 12490 8 from from IN cord-010092-uftc8inx 12490 9 two two CD cord-010092-uftc8inx 12490 10 K k NN cord-010092-uftc8inx 12490 11 - - HYPH cord-010092-uftc8inx 12490 12 negative negative JJ cord-010092-uftc8inx 12490 13 pregnant pregnant JJ cord-010092-uftc8inx 12490 14 women woman NNS cord-010092-uftc8inx 12490 15 carrying carry VBG cord-010092-uftc8inx 12490 16 K k NN cord-010092-uftc8inx 12490 17 - - HYPH cord-010092-uftc8inx 12490 18 positive positive JJ cord-010092-uftc8inx 12490 19 fetus fetus NN cord-010092-uftc8inx 12490 20 gave give VBD cord-010092-uftc8inx 12490 21 false false JJ cord-010092-uftc8inx 12490 22 KEL*1-negative kel*1-negative JJ cord-010092-uftc8inx 12490 23 results result NNS cord-010092-uftc8inx 12490 24 in in IN cord-010092-uftc8inx 12490 25 DNA dna NN cord-010092-uftc8inx 12490 26 samples sample NNS cord-010092-uftc8inx 12490 27 tested test VBN cord-010092-uftc8inx 12490 28 after after IN cord-010092-uftc8inx 12490 29 gel gel NN cord-010092-uftc8inx 12490 30 selection selection NN cord-010092-uftc8inx 12490 31 comparing compare VBG cord-010092-uftc8inx 12490 32 to to IN cord-010092-uftc8inx 12490 33 non non JJ cord-010092-uftc8inx 12490 34 - - JJ cord-010092-uftc8inx 12490 35 processed process VBN cord-010092-uftc8inx 12490 36 DNA dna NN cord-010092-uftc8inx 12490 37 samples sample NNS cord-010092-uftc8inx 12490 38 were be VBD cord-010092-uftc8inx 12490 39 KEL*1 kel*1 CD cord-010092-uftc8inx 12490 40 positive positive JJ cord-010092-uftc8inx 12490 41 genotype genotype NN cord-010092-uftc8inx 12490 42 was be VBD cord-010092-uftc8inx 12490 43 obtained obtain VBN cord-010092-uftc8inx 12490 44 . . . cord-010092-uftc8inx 12491 1 The the DT cord-010092-uftc8inx 12491 2 total total JJ cord-010092-uftc8inx 12491 3 DNA dna NN cord-010092-uftc8inx 12491 4 level level NN cord-010092-uftc8inx 12491 5 in in IN cord-010092-uftc8inx 12491 6 samples sample NNS cord-010092-uftc8inx 12491 7 from from IN cord-010092-uftc8inx 12491 8 K k NN cord-010092-uftc8inx 12491 9 - - HYPH cord-010092-uftc8inx 12491 10 negative negative JJ cord-010092-uftc8inx 12491 11 women woman NNS cord-010092-uftc8inx 12491 12 was be VBD cord-010092-uftc8inx 12491 13 from from IN cord-010092-uftc8inx 12491 14 18.3 18.3 CD cord-010092-uftc8inx 12491 15 to to IN cord-010092-uftc8inx 12491 16 18.7geq 18.7geq CD cord-010092-uftc8inx 12491 17 CCR5 CCR5 NNP cord-010092-uftc8inx 12491 18 / / SYM cord-010092-uftc8inx 12491 19 PCR PCR NNP cord-010092-uftc8inx 12491 20 after after IN cord-010092-uftc8inx 12491 21 gel gel NN cord-010092-uftc8inx 12491 22 selection selection NN cord-010092-uftc8inx 12491 23 versus versus IN cord-010092-uftc8inx 12491 24 from from IN cord-010092-uftc8inx 12491 25 52 52 CD cord-010092-uftc8inx 12491 26 to to IN cord-010092-uftc8inx 12491 27 746geq 746geq CD cord-010092-uftc8inx 12491 28 CCR5/ CCR5/ NNP cord-010092-uftc8inx 12491 29 PCR PCR NNP cord-010092-uftc8inx 12491 30 in in IN cord-010092-uftc8inx 12491 31 non non JJ cord-010092-uftc8inx 12491 32 - - JJ cord-010092-uftc8inx 12491 33 processed process VBN cord-010092-uftc8inx 12491 34 DNA dna NN cord-010092-uftc8inx 12491 35 samples sample NNS cord-010092-uftc8inx 12491 36 . . . cord-010092-uftc8inx 12492 1 Summary Summary NNP cord-010092-uftc8inx 12492 2 / / SYM cord-010092-uftc8inx 12492 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 12492 4 : : : cord-010092-uftc8inx 12493 1 Using use VBG cord-010092-uftc8inx 12493 2 the the DT cord-010092-uftc8inx 12493 3 Pippin Pippin NNP cord-010092-uftc8inx 12493 4 Prep Prep NNP cord-010092-uftc8inx 12493 5 gel gel NN cord-010092-uftc8inx 12493 6 selection selection NN cord-010092-uftc8inx 12493 7 system system NN cord-010092-uftc8inx 12493 8 increases increase VBZ cord-010092-uftc8inx 12493 9 the the DT cord-010092-uftc8inx 12493 10 proportion proportion NN cord-010092-uftc8inx 12493 11 of of IN cord-010092-uftc8inx 12493 12 cffDNA cffdna JJ cord-010092-uftc8inx 12493 13 fraction fraction NN cord-010092-uftc8inx 12493 14 in in IN cord-010092-uftc8inx 12493 15 total total JJ cord-010092-uftc8inx 12493 16 plasma plasma NN cord-010092-uftc8inx 12493 17 DNA dna NN cord-010092-uftc8inx 12493 18 by by IN cord-010092-uftc8inx 12493 19 retaining retain VBG cord-010092-uftc8inx 12493 20 long long JJ cord-010092-uftc8inx 12493 21 maternal maternal JJ cord-010092-uftc8inx 12493 22 DNA dna NN cord-010092-uftc8inx 12493 23 fragments fragment NNS cord-010092-uftc8inx 12493 24 in in IN cord-010092-uftc8inx 12493 25 the the DT cord-010092-uftc8inx 12493 26 gel gel NN cord-010092-uftc8inx 12493 27 cassettes cassette NNS cord-010092-uftc8inx 12493 28 , , , cord-010092-uftc8inx 12493 29 but but CC cord-010092-uftc8inx 12493 30 the the DT cord-010092-uftc8inx 12493 31 protocol protocol NN cord-010092-uftc8inx 12493 32 of of IN cord-010092-uftc8inx 12493 33 gel gel NN cord-010092-uftc8inx 12493 34 separation separation NN cord-010092-uftc8inx 12493 35 dilutes dilute VBZ cord-010092-uftc8inx 12493 36 the the DT cord-010092-uftc8inx 12493 37 separated separated JJ cord-010092-uftc8inx 12493 38 material material NN cord-010092-uftc8inx 12493 39 decreasing decrease VBG cord-010092-uftc8inx 12493 40 the the DT cord-010092-uftc8inx 12493 41 concentration concentration NN cord-010092-uftc8inx 12493 42 of of IN cord-010092-uftc8inx 12493 43 fetal fetal JJ cord-010092-uftc8inx 12493 44 DNA dna NN cord-010092-uftc8inx 12493 45 and and CC cord-010092-uftc8inx 12493 46 leading lead VBG cord-010092-uftc8inx 12493 47 to to IN cord-010092-uftc8inx 12493 48 false false JJ cord-010092-uftc8inx 12493 49 negative negative JJ cord-010092-uftc8inx 12493 50 results result NNS cord-010092-uftc8inx 12493 51 of of IN cord-010092-uftc8inx 12493 52 NIPT NIPT NNP cord-010092-uftc8inx 12493 53 . . . cord-010092-uftc8inx 12494 1 ANTI anti JJ cord-010092-uftc8inx 12494 2 - - JJ cord-010092-uftc8inx 12494 3 RH1 rh1 NN cord-010092-uftc8inx 12494 4 QUANTIFICATION quantification NN cord-010092-uftc8inx 12494 5 ASSAY assay NN cord-010092-uftc8inx 12494 6 USING use VBG cord-010092-uftc8inx 12494 7 IH-500 IH-500 VBD cord-010092-uftc8inx 12495 1 ( ( -LRB- cord-010092-uftc8inx 12495 2 BIO BIO NNP cord-010092-uftc8inx 12495 3 - - HYPH cord-010092-uftc8inx 12495 4 RAD RAD NNP cord-010092-uftc8inx 12496 1 â â LS cord-010092-uftc8inx 12497 1 ): ): NNP cord-010092-uftc8inx 12498 1 PROMISING promising JJ cord-010092-uftc8inx 12498 2 RESULTS result NNS cord-010092-uftc8inx 12498 3 FOR for IN cord-010092-uftc8inx 12498 4 MONITORING monitoring NN cord-010092-uftc8inx 12499 1 RH:-1 rh:-1 CD cord-010092-uftc8inx 12500 1 PREGNANT pregnant JJ cord-010092-uftc8inx 12500 2 WOMEN woman NNS cord-010092-uftc8inx 12500 3 J J NNP cord-010092-uftc8inx 12500 4 Beaud Beaud NNP cord-010092-uftc8inx 12500 5 , , , cord-010092-uftc8inx 12500 6 H H NNP cord-010092-uftc8inx 12500 7 Delaby Delaby NNP cord-010092-uftc8inx 12500 8 , , , cord-010092-uftc8inx 12500 9 C C NNP cord-010092-uftc8inx 12500 10 Toly Toly NNP cord-010092-uftc8inx 12500 11 - - HYPH cord-010092-uftc8inx 12500 12 Ndour Ndour NNP cord-010092-uftc8inx 12500 13 , , , cord-010092-uftc8inx 12500 14 A A NNP cord-010092-uftc8inx 12500 15 Mailloux Mailloux NNP cord-010092-uftc8inx 12500 16 and and CC cord-010092-uftc8inx 12500 17 S S NNP cord-010092-uftc8inx 12500 18 Huguet Huguet NNP cord-010092-uftc8inx 12500 19 - - HYPH cord-010092-uftc8inx 12500 20 Jacquot Jacquot NNP cord-010092-uftc8inx 12500 21 Centre Centre NNP cord-010092-uftc8inx 12500 22 National National NNP cord-010092-uftc8inx 12500 23 de de NNP cord-010092-uftc8inx 12500 24 R R NNP cord-010092-uftc8inx 12500 25 ef ef NN cord-010092-uftc8inx 12500 26 erence erence NN cord-010092-uftc8inx 12500 27 en en IN cord-010092-uftc8inx 12500 28 H h NN cord-010092-uftc8inx 12500 29 emobiologie emobiologie NN cord-010092-uftc8inx 12500 30 P p NN cord-010092-uftc8inx 12500 31 erinatale erinatale NN cord-010092-uftc8inx 12500 32 ( ( -LRB- cord-010092-uftc8inx 12500 33 CNRHP CNRHP NNP cord-010092-uftc8inx 12500 34 ) ) -RRB- cord-010092-uftc8inx 12500 35 , , , cord-010092-uftc8inx 12500 36 Hôpital Hôpital NNP cord-010092-uftc8inx 12500 37 Saint Saint NNP cord-010092-uftc8inx 12500 38 - - HYPH cord-010092-uftc8inx 12500 39 Antoine Antoine NNP cord-010092-uftc8inx 12500 40 , , , cord-010092-uftc8inx 12500 41 Paris Paris NNP cord-010092-uftc8inx 12500 42 , , , cord-010092-uftc8inx 12500 43 FranceBackground FranceBackground NNP cord-010092-uftc8inx 12500 44 : : : cord-010092-uftc8inx 12501 1 The the DT cord-010092-uftc8inx 12501 2 generalization generalization NN cord-010092-uftc8inx 12501 3 of of IN cord-010092-uftc8inx 12501 4 immunoprophylaxis immunoprophylaxis NNP cord-010092-uftc8inx 12501 5 by by IN cord-010092-uftc8inx 12501 6 anti anti JJ cord-010092-uftc8inx 12501 7 - - JJ cord-010092-uftc8inx 12501 8 RH1 rh1 JJ cord-010092-uftc8inx 12501 9 immunoglobulins immunoglobulin NNS cord-010092-uftc8inx 12501 10 since since IN cord-010092-uftc8inx 12501 11 1970 1970 CD cord-010092-uftc8inx 12501 12 complicates complicate VBZ cord-010092-uftc8inx 12501 13 the the DT cord-010092-uftc8inx 12501 14 interpretation interpretation NN cord-010092-uftc8inx 12501 15 of of IN cord-010092-uftc8inx 12501 16 the the DT cord-010092-uftc8inx 12501 17 anti anti JJ cord-010092-uftc8inx 12501 18 - - JJ cord-010092-uftc8inx 12501 19 red red JJ cord-010092-uftc8inx 12501 20 blood blood NN cord-010092-uftc8inx 12501 21 cell cell NN cord-010092-uftc8inx 12501 22 antibodies antibody NNS cord-010092-uftc8inx 12501 23 screening screen VBG cord-010092-uftc8inx 12501 24 during during IN cord-010092-uftc8inx 12501 25 pregnancy pregnancy NN cord-010092-uftc8inx 12501 26 . . . cord-010092-uftc8inx 12502 1 To to TO cord-010092-uftc8inx 12502 2 distinguish distinguish VB cord-010092-uftc8inx 12502 3 an an DT cord-010092-uftc8inx 12502 4 alloantibody alloantibody NN cord-010092-uftc8inx 12502 5 from from IN cord-010092-uftc8inx 12502 6 a a DT cord-010092-uftc8inx 12502 7 passive passive JJ cord-010092-uftc8inx 12502 8 one one NN cord-010092-uftc8inx 12502 9 , , , cord-010092-uftc8inx 12502 10 many many JJ cord-010092-uftc8inx 12502 11 laboratories laboratory NNS cord-010092-uftc8inx 12502 12 in in IN cord-010092-uftc8inx 12502 13 France France NNP cord-010092-uftc8inx 12502 14 use use VBP cord-010092-uftc8inx 12502 15 anti anti JJ cord-010092-uftc8inx 12502 16 - - JJ cord-010092-uftc8inx 12502 17 RH1 rh1 JJ cord-010092-uftc8inx 12502 18 microtitration microtitration NN cord-010092-uftc8inx 12502 19 . . . cord-010092-uftc8inx 12503 1 It -PRON- PRP cord-010092-uftc8inx 12503 2 is be VBZ cord-010092-uftc8inx 12503 3 a a DT cord-010092-uftc8inx 12503 4 column column NN cord-010092-uftc8inx 12503 5 agglutination agglutination NN cord-010092-uftc8inx 12503 6 technology technology NN cord-010092-uftc8inx 12503 7 using use VBG cord-010092-uftc8inx 12503 8 red red JJ cord-010092-uftc8inx 12503 9 blood blood NN cord-010092-uftc8inx 12503 10 cells cell NNS cord-010092-uftc8inx 12503 11 RH RH NNP cord-010092-uftc8inx 12503 12 : : : cord-010092-uftc8inx 12503 13 1 1 CD cord-010092-uftc8inx 12503 14 , , , cord-010092-uftc8inx 12503 15 -2 -2 NNP cord-010092-uftc8inx 12503 16 , , , cord-010092-uftc8inx 12503 17 -3,4,5 -3,4,5 NNP cord-010092-uftc8inx 12503 18 ( ( -LRB- cord-010092-uftc8inx 12503 19 R0r r0r NN cord-010092-uftc8inx 12503 20 ) ) -RRB- cord-010092-uftc8inx 12503 21 . . . cord-010092-uftc8inx 12504 1 It -PRON- PRP cord-010092-uftc8inx 12504 2 permits permit VBZ cord-010092-uftc8inx 12504 3 to to TO cord-010092-uftc8inx 12504 4 quantify quantify VB cord-010092-uftc8inx 12504 5 low low JJ cord-010092-uftc8inx 12504 6 levels level NNS cord-010092-uftc8inx 12504 7 of of IN cord-010092-uftc8inx 12504 8 anti anti JJ cord-010092-uftc8inx 12504 9 - - JJ cord-010092-uftc8inx 12504 10 RH1 rh1 NN cord-010092-uftc8inx 12504 11 in in IN cord-010092-uftc8inx 12504 12 comparison comparison NN cord-010092-uftc8inx 12504 13 to to IN cord-010092-uftc8inx 12504 14 a a DT cord-010092-uftc8inx 12504 15 range range NN cord-010092-uftc8inx 12504 16 of of IN cord-010092-uftc8inx 12504 17 an an DT cord-010092-uftc8inx 12504 18 anti anti JJ cord-010092-uftc8inx 12504 19 - - JJ cord-010092-uftc8inx 12504 20 RH1 rh1 JJ cord-010092-uftc8inx 12504 21 standard standard NN cord-010092-uftc8inx 12504 22 . . . cord-010092-uftc8inx 12505 1 Performed perform VBN cord-010092-uftc8inx 12505 2 since since IN cord-010092-uftc8inx 12505 3 1999 1999 CD cord-010092-uftc8inx 12505 4 at at IN cord-010092-uftc8inx 12505 5 the the DT cord-010092-uftc8inx 12505 6 CNRHP CNRHP NNP cord-010092-uftc8inx 12505 7 and and CC cord-010092-uftc8inx 12505 8 automated automate VBN cord-010092-uftc8inx 12505 9 on on IN cord-010092-uftc8inx 12505 10 Evo Evo NNP cord-010092-uftc8inx 12505 11 clinical clinical JJ cord-010092-uftc8inx 12505 12 Base Base NNP cord-010092-uftc8inx 12505 13 Tecan Tecan NNP cord-010092-uftc8inx 12505 14 in in IN cord-010092-uftc8inx 12505 15 2008 2008 CD cord-010092-uftc8inx 12505 16 ( ( -LRB- cord-010092-uftc8inx 12505 17 dilutions dilution NNS cord-010092-uftc8inx 12505 18 and and CC cord-010092-uftc8inx 12505 19 distribution distribution NN cord-010092-uftc8inx 12505 20 ) ) -RRB- cord-010092-uftc8inx 12505 21 , , , cord-010092-uftc8inx 12505 22 anti anti JJ cord-010092-uftc8inx 12505 23 - - JJ cord-010092-uftc8inx 12505 24 RH1 rh1 JJ cord-010092-uftc8inx 12505 25 microtitration microtitration NN cord-010092-uftc8inx 12505 26 is be VBZ cord-010092-uftc8inx 12505 27 well well RB cord-010092-uftc8inx 12505 28 adapted adapt VBN cord-010092-uftc8inx 12505 29 to to IN cord-010092-uftc8inx 12505 30 Rh Rh NNP cord-010092-uftc8inx 12505 31 prophylaxis prophylaxis NN cord-010092-uftc8inx 12505 32 . . . cord-010092-uftc8inx 12506 1 Aims aim VBZ cord-010092-uftc8inx 12506 2 : : : cord-010092-uftc8inx 12507 1 The the DT cord-010092-uftc8inx 12507 2 aim aim NN cord-010092-uftc8inx 12507 3 of of IN cord-010092-uftc8inx 12507 4 this this DT cord-010092-uftc8inx 12507 5 study study NN cord-010092-uftc8inx 12507 6 was be VBD cord-010092-uftc8inx 12507 7 to to TO cord-010092-uftc8inx 12507 8 evaluate evaluate VB cord-010092-uftc8inx 12507 9 this this DT cord-010092-uftc8inx 12507 10 technique technique NN cord-010092-uftc8inx 12507 11 on on IN cord-010092-uftc8inx 12507 12 the the DT cord-010092-uftc8inx 12507 13 IH-500 IH-500 NNP cord-010092-uftc8inx 12507 14 system system NN cord-010092-uftc8inx 12507 15 from from IN cord-010092-uftc8inx 12507 16 Bio Bio NNP cord-010092-uftc8inx 12507 17 - - HYPH cord-010092-uftc8inx 12507 18 Rad Rad NNP cord-010092-uftc8inx 12507 19 â â NNP cord-010092-uftc8inx 12507 20 . . . cord-010092-uftc8inx 12508 1 Methods method NNS cord-010092-uftc8inx 12508 2 : : : cord-010092-uftc8inx 12509 1 On on IN cord-010092-uftc8inx 12509 2 IH-500 IH-500 NNP cord-010092-uftc8inx 12509 3 , , , cord-010092-uftc8inx 12509 4 the the DT cord-010092-uftc8inx 12509 5 reactivity reactivity NN cord-010092-uftc8inx 12509 6 of of IN cord-010092-uftc8inx 12509 7 the the DT cord-010092-uftc8inx 12509 8 Bio Bio NNP cord-010092-uftc8inx 12509 9 - - HYPH cord-010092-uftc8inx 12509 10 Rad Rad NNP cord-010092-uftc8inx 12509 11 â â , cord-010092-uftc8inx 12509 12 reagents reagent NNS cord-010092-uftc8inx 12509 13 was be VBD cord-010092-uftc8inx 12509 14 compared compare VBN cord-010092-uftc8inx 12509 15 with with IN cord-010092-uftc8inx 12509 16 the the DT cord-010092-uftc8inx 12509 17 CNRHP CNRHP NNP cord-010092-uftc8inx 12509 18 reagents reagent NNS cord-010092-uftc8inx 12509 19 ( ( -LRB- cord-010092-uftc8inx 12509 20 red red JJ cord-010092-uftc8inx 12509 21 blood blood NN cord-010092-uftc8inx 12509 22 cells cell NNS cord-010092-uftc8inx 12509 23 R0r R0r NNS cord-010092-uftc8inx 12509 24 , , , cord-010092-uftc8inx 12509 25 anti anti JJ cord-010092-uftc8inx 12509 26 - - JJ cord-010092-uftc8inx 12509 27 RH1 rh1 JJ cord-010092-uftc8inx 12509 28 standard standard NN cord-010092-uftc8inx 12509 29 ) ) -RRB- cord-010092-uftc8inx 12509 30 . . . cord-010092-uftc8inx 12510 1 The the DT cord-010092-uftc8inx 12510 2 performances performance NNS cord-010092-uftc8inx 12510 3 of of IN cord-010092-uftc8inx 12510 4 the the DT cord-010092-uftc8inx 12510 5 method method NN cord-010092-uftc8inx 12510 6 were be VBD cord-010092-uftc8inx 12510 7 evaluated evaluate VBN cord-010092-uftc8inx 12510 8 using use VBG cord-010092-uftc8inx 12510 9 three three CD cord-010092-uftc8inx 12510 10 internal internal JJ cord-010092-uftc8inx 12510 11 quality quality NN cord-010092-uftc8inx 12510 12 control control NN cord-010092-uftc8inx 12510 13 ( ( -LRB- cord-010092-uftc8inx 12510 14 ICQ ICQ NNP cord-010092-uftc8inx 12510 15 ) ) -RRB- cord-010092-uftc8inx 12510 16 ( ( -LRB- cord-010092-uftc8inx 12510 17 2 2 CD cord-010092-uftc8inx 12510 18 CNRHP CNRHP NNP cord-010092-uftc8inx 12510 19 home home NN cord-010092-uftc8inx 12510 20 - - HYPH cord-010092-uftc8inx 12510 21 made make VBN cord-010092-uftc8inx 12510 22 at at IN cord-010092-uftc8inx 12510 23 2 2 CD cord-010092-uftc8inx 12510 24 and and CC cord-010092-uftc8inx 12510 25 12 12 CD cord-010092-uftc8inx 12510 26 ng ng NN cord-010092-uftc8inx 12510 27 / / SYM cord-010092-uftc8inx 12510 28 ml ml NN cord-010092-uftc8inx 12510 29 and and CC cord-010092-uftc8inx 12510 30 1 1 CD cord-010092-uftc8inx 12510 31 Bio Bio NNP cord-010092-uftc8inx 12510 32 - - HYPH cord-010092-uftc8inx 12510 33 Rad Rad NNP cord-010092-uftc8inx 12510 34 â â NN cord-010092-uftc8inx 12510 35 at at IN cord-010092-uftc8inx 12510 36 12 12 CD cord-010092-uftc8inx 12510 37 ng ng NN cord-010092-uftc8inx 12510 38 / / SYM cord-010092-uftc8inx 12510 39 ml ml NNP cord-010092-uftc8inx 12510 40 ) ) -RRB- cord-010092-uftc8inx 12510 41 on on IN cord-010092-uftc8inx 12510 42 papainized papainized NNP cord-010092-uftc8inx 12510 43 R0r R0r NNP cord-010092-uftc8inx 12510 44 ( ( -LRB- cord-010092-uftc8inx 12510 45 PLC PLC NNP cord-010092-uftc8inx 12510 46 ) ) -RRB- cord-010092-uftc8inx 12510 47 and and CC cord-010092-uftc8inx 12510 48 native native JJ cord-010092-uftc8inx 12510 49 R0r r0r NN cord-010092-uftc8inx 12510 50 ( ( -LRB- cord-010092-uftc8inx 12510 51 NLC NLC NNP cord-010092-uftc8inx 12510 52 ) ) -RRB- cord-010092-uftc8inx 12510 53 . . . cord-010092-uftc8inx 12511 1 A a DT cord-010092-uftc8inx 12511 2 comparison comparison NN cord-010092-uftc8inx 12511 3 of of IN cord-010092-uftc8inx 12511 4 results result NNS cord-010092-uftc8inx 12511 5 from from IN cord-010092-uftc8inx 12511 6 patient patient NN cord-010092-uftc8inx 12511 7 sera sera NNP cord-010092-uftc8inx 12511 8 ranging range VBG cord-010092-uftc8inx 12511 9 from from IN cord-010092-uftc8inx 12511 10 1.5 1.5 CD cord-010092-uftc8inx 12511 11 to to IN cord-010092-uftc8inx 12511 12 48 48 CD cord-010092-uftc8inx 12511 13 ng ng NN cord-010092-uftc8inx 12511 14 / / SYM cord-010092-uftc8inx 12511 15 ml ml NN cord-010092-uftc8inx 12511 16 was be VBD cord-010092-uftc8inx 12511 17 done do VBN cord-010092-uftc8inx 12511 18 between between IN cord-010092-uftc8inx 12511 19 IH-500 IH-500 NNP cord-010092-uftc8inx 12511 20 and and CC cord-010092-uftc8inx 12511 21 Evo Evo NNP cord-010092-uftc8inx 12511 22 clinical clinical JJ cord-010092-uftc8inx 12511 23 Base Base NNP cord-010092-uftc8inx 12511 24 Tecan Tecan NNP cord-010092-uftc8inx 12511 25 . . . cord-010092-uftc8inx 12512 1 Results result NNS cord-010092-uftc8inx 12512 2 : : : cord-010092-uftc8inx 12513 1 The the DT cord-010092-uftc8inx 12513 2 results result NNS cord-010092-uftc8inx 12513 3 of of IN cord-010092-uftc8inx 12513 4 the the DT cord-010092-uftc8inx 12513 5 3 3 CD cord-010092-uftc8inx 12513 6 QCI QCI NNP cord-010092-uftc8inx 12513 7 are be VBP cord-010092-uftc8inx 12513 8 similar similar JJ cord-010092-uftc8inx 12513 9 between between IN cord-010092-uftc8inx 12513 10 the the DT cord-010092-uftc8inx 12513 11 different different JJ cord-010092-uftc8inx 12513 12 reagents reagent NNS cord-010092-uftc8inx 12513 13 used use VBN cord-010092-uftc8inx 12513 14 . . . cord-010092-uftc8inx 12514 1 There there EX cord-010092-uftc8inx 12514 2 is be VBZ cord-010092-uftc8inx 12514 3 no no DT cord-010092-uftc8inx 12514 4 significant significant JJ cord-010092-uftc8inx 12514 5 difference difference NN cord-010092-uftc8inx 12514 6 between between IN cord-010092-uftc8inx 12514 7 the the DT cord-010092-uftc8inx 12514 8 2 2 CD cord-010092-uftc8inx 12514 9 types type NNS cord-010092-uftc8inx 12514 10 of of IN cord-010092-uftc8inx 12514 11 red red JJ cord-010092-uftc8inx 12514 12 blood blood NN cord-010092-uftc8inx 12514 13 cells cell NNS cord-010092-uftc8inx 12514 14 except except IN cord-010092-uftc8inx 12514 15 for for IN cord-010092-uftc8inx 12514 16 the the DT cord-010092-uftc8inx 12514 17 limit limit NN cord-010092-uftc8inx 12514 18 of of IN cord-010092-uftc8inx 12514 19 detection detection NN cord-010092-uftc8inx 12514 20 : : : cord-010092-uftc8inx 12514 21 1.5 1.5 CD cord-010092-uftc8inx 12514 22 ng ng NN cord-010092-uftc8inx 12514 23 / / SYM cord-010092-uftc8inx 12514 24 ml ml NN cord-010092-uftc8inx 12514 25 in in IN cord-010092-uftc8inx 12514 26 PLC PLC NNP cord-010092-uftc8inx 12514 27 -6 -6 NNP cord-010092-uftc8inx 12514 28 ng ng NNP cord-010092-uftc8inx 12514 29 / / SYM cord-010092-uftc8inx 12514 30 ml ml NN cord-010092-uftc8inx 12514 31 in in IN cord-010092-uftc8inx 12514 32 NLC NLC NNP cord-010092-uftc8inx 12514 33 . . . cord-010092-uftc8inx 12515 1 For for IN cord-010092-uftc8inx 12515 2 the the DT cord-010092-uftc8inx 12515 3 3 3 CD cord-010092-uftc8inx 12515 4 QCI QCI NNP cord-010092-uftc8inx 12515 5 , , , cord-010092-uftc8inx 12515 6 the the DT cord-010092-uftc8inx 12515 7 intra intra JJ cord-010092-uftc8inx 12515 8 and and CC cord-010092-uftc8inx 12515 9 interassay interassay JJ cord-010092-uftc8inx 12515 10 imprecision imprecision NN cord-010092-uftc8inx 12515 11 based base VBN cord-010092-uftc8inx 12515 12 on on IN cord-010092-uftc8inx 12515 13 the the DT cord-010092-uftc8inx 12515 14 dilution dilution NN cord-010092-uftc8inx 12515 15 degree degree NN cord-010092-uftc8inx 12515 16 show show NN cord-010092-uftc8inx 12515 17 coefficients coefficient NNS cord-010092-uftc8inx 12515 18 of of IN cord-010092-uftc8inx 12515 19 variation variation NN cord-010092-uftc8inx 12515 20 between between IN cord-010092-uftc8inx 12515 21 0 0 CD cord-010092-uftc8inx 12515 22 and and CC cord-010092-uftc8inx 12515 23 15 15 CD cord-010092-uftc8inx 12515 24 % % NN cord-010092-uftc8inx 12515 25 , , , cord-010092-uftc8inx 12515 26 similar similar JJ cord-010092-uftc8inx 12515 27 to to IN cord-010092-uftc8inx 12515 28 those those DT cord-010092-uftc8inx 12515 29 found find VBN cord-010092-uftc8inx 12515 30 with with IN cord-010092-uftc8inx 12515 31 the the DT cord-010092-uftc8inx 12515 32 Evo Evo NNP cord-010092-uftc8inx 12515 33 Clinical Clinical NNP cord-010092-uftc8inx 12515 34 Base Base NNP cord-010092-uftc8inx 12515 35 . . . cord-010092-uftc8inx 12516 1 The the DT cord-010092-uftc8inx 12516 2 correlation correlation NN cord-010092-uftc8inx 12516 3 with with IN cord-010092-uftc8inx 12516 4 the the DT cord-010092-uftc8inx 12516 5 CNRHP CNRHP NNP cord-010092-uftc8inx 12516 6 technique technique NN cord-010092-uftc8inx 12516 7 performed perform VBN cord-010092-uftc8inx 12516 8 on on IN cord-010092-uftc8inx 12516 9 50 50 CD cord-010092-uftc8inx 12516 10 samples sample NNS cord-010092-uftc8inx 12516 11 in in IN cord-010092-uftc8inx 12516 12 PLC PLC NNP cord-010092-uftc8inx 12516 13 and and CC cord-010092-uftc8inx 12516 14 44 44 CD cord-010092-uftc8inx 12516 15 samples sample NNS cord-010092-uftc8inx 12516 16 in in IN cord-010092-uftc8inx 12516 17 NLC NLC NNP cord-010092-uftc8inx 12516 18 was be VBD cord-010092-uftc8inx 12516 19 satisfactory satisfactory JJ cord-010092-uftc8inx 12516 20 ( ( -LRB- cord-010092-uftc8inx 12516 21 Deming Deming NNP cord-010092-uftc8inx 12516 22 PLC PLC NNP cord-010092-uftc8inx 12516 23 : : : cord-010092-uftc8inx 12516 24 r2 r2 NNP cord-010092-uftc8inx 12516 25 = = SYM cord-010092-uftc8inx 12516 26 0.80 0.80 CD cord-010092-uftc8inx 12516 27 Y y NN cord-010092-uftc8inx 12516 28 = = SYM cord-010092-uftc8inx 12516 29 0.89X 0.89X : cord-010092-uftc8inx 12516 30 + + CC cord-010092-uftc8inx 12517 1 0.78 0.78 CD cord-010092-uftc8inx 12517 2 -NLC -NLC . cord-010092-uftc8inx 12518 1 : : : cord-010092-uftc8inx 12518 2 r2 r2 NNP cord-010092-uftc8inx 12518 3 = = SYM cord-010092-uftc8inx 12518 4 0.86 0.86 CD cord-010092-uftc8inx 12518 5 Y Y NNP cord-010092-uftc8inx 12518 6 = = NN cord-010092-uftc8inx 12518 7 1.08X-0.25 1.08x-0.25 CD cord-010092-uftc8inx 12518 8 ) ) -RRB- cord-010092-uftc8inx 12518 9 . . . cord-010092-uftc8inx 12519 1 Summary Summary NNP cord-010092-uftc8inx 12519 2 / / SYM cord-010092-uftc8inx 12519 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 12519 4 : : : cord-010092-uftc8inx 12520 1 The the DT cord-010092-uftc8inx 12520 2 anti anti JJ cord-010092-uftc8inx 12520 3 - - JJ cord-010092-uftc8inx 12520 4 RH1 rh1 JJ cord-010092-uftc8inx 12520 5 microtitration microtitration NN cord-010092-uftc8inx 12520 6 on on IN cord-010092-uftc8inx 12520 7 the the DT cord-010092-uftc8inx 12520 8 IH-500 IH-500 NNP cord-010092-uftc8inx 12520 9 offers offer VBZ cord-010092-uftc8inx 12520 10 similar similar JJ cord-010092-uftc8inx 12520 11 performances performance NNS cord-010092-uftc8inx 12520 12 to to IN cord-010092-uftc8inx 12520 13 the the DT cord-010092-uftc8inx 12520 14 method method NN cord-010092-uftc8inx 12520 15 conducted conduct VBN cord-010092-uftc8inx 12520 16 at at IN cord-010092-uftc8inx 12520 17 the the DT cord-010092-uftc8inx 12520 18 CNRHP CNRHP NNP cord-010092-uftc8inx 12520 19 . . . cord-010092-uftc8inx 12521 1 The the DT cord-010092-uftc8inx 12521 2 IH-500 ih-500 FW cord-010092-uftc8inx 12521 3 allows allow VBZ cord-010092-uftc8inx 12521 4 automated automate VBN cord-010092-uftc8inx 12521 5 reading reading NN cord-010092-uftc8inx 12521 6 of of IN cord-010092-uftc8inx 12521 7 gel gel NN cord-010092-uftc8inx 12521 8 cards card NNS cord-010092-uftc8inx 12521 9 . . . cord-010092-uftc8inx 12522 1 However however RB cord-010092-uftc8inx 12522 2 , , , cord-010092-uftc8inx 12522 3 it -PRON- PRP cord-010092-uftc8inx 12522 4 does do VBZ cord-010092-uftc8inx 12522 5 not not RB cord-010092-uftc8inx 12522 6 have have VB cord-010092-uftc8inx 12522 7 a a DT cord-010092-uftc8inx 12522 8 calculation calculation NN cord-010092-uftc8inx 12522 9 or or CC cord-010092-uftc8inx 12522 10 interpretation interpretation NN cord-010092-uftc8inx 12522 11 algorithm algorithm NN cord-010092-uftc8inx 12522 12 and and CC cord-010092-uftc8inx 12522 13 does do VBZ cord-010092-uftc8inx 12522 14 not not RB cord-010092-uftc8inx 12522 15 directly directly RB cord-010092-uftc8inx 12522 16 give give VB cord-010092-uftc8inx 12522 17 the the DT cord-010092-uftc8inx 12522 18 concentration concentration NN cord-010092-uftc8inx 12522 19 of of IN cord-010092-uftc8inx 12522 20 anti anti JJ cord-010092-uftc8inx 12522 21 - - JJ cord-010092-uftc8inx 12522 22 RH1 rh1 NN cord-010092-uftc8inx 12522 23 . . . cord-010092-uftc8inx 12523 1 This this DT cord-010092-uftc8inx 12523 2 final final JJ cord-010092-uftc8inx 12523 3 part part NN cord-010092-uftc8inx 12523 4 remains remain VBZ cord-010092-uftc8inx 12523 5 manual manual JJ cord-010092-uftc8inx 12523 6 and and CC cord-010092-uftc8inx 12523 7 requires require VBZ cord-010092-uftc8inx 12523 8 trained train VBN cord-010092-uftc8inx 12523 9 staff staff NN cord-010092-uftc8inx 12523 10 . . . cord-010092-uftc8inx 12524 1 Background background NN cord-010092-uftc8inx 12524 2 : : : cord-010092-uftc8inx 12525 1 Haemolytic haemolytic JJ cord-010092-uftc8inx 12525 2 disease disease NN cord-010092-uftc8inx 12525 3 of of IN cord-010092-uftc8inx 12525 4 the the DT cord-010092-uftc8inx 12525 5 foetus foetus NN cord-010092-uftc8inx 12525 6 and and CC cord-010092-uftc8inx 12525 7 newborn newborn JJ cord-010092-uftc8inx 12525 8 ( ( -LRB- cord-010092-uftc8inx 12525 9 HDFN HDFN NNP cord-010092-uftc8inx 12525 10 ) ) -RRB- cord-010092-uftc8inx 12525 11 due due JJ cord-010092-uftc8inx 12525 12 to to IN cord-010092-uftc8inx 12525 13 maternal maternal JJ cord-010092-uftc8inx 12525 14 - - HYPH cord-010092-uftc8inx 12525 15 foetal foetal JJ cord-010092-uftc8inx 12525 16 incompatibility incompatibility NN cord-010092-uftc8inx 12525 17 has have VBZ cord-010092-uftc8inx 12525 18 been be VBN cord-010092-uftc8inx 12525 19 perfectly perfectly RB cord-010092-uftc8inx 12525 20 framed frame VBN cord-010092-uftc8inx 12525 21 for for IN cord-010092-uftc8inx 12525 22 decades decade NNS cord-010092-uftc8inx 12525 23 from from IN cord-010092-uftc8inx 12525 24 the the DT cord-010092-uftc8inx 12525 25 etiologic etiologic NNP cord-010092-uftc8inx 12525 26 , , , cord-010092-uftc8inx 12525 27 pathogenetic pathogenetic JJ cord-010092-uftc8inx 12525 28 and and CC cord-010092-uftc8inx 12525 29 therapeutic therapeutic JJ cord-010092-uftc8inx 12525 30 point point NN cord-010092-uftc8inx 12525 31 of of IN cord-010092-uftc8inx 12525 32 view view NN cord-010092-uftc8inx 12525 33 . . . cord-010092-uftc8inx 12526 1 The the DT cord-010092-uftc8inx 12526 2 anti anti JJ cord-010092-uftc8inx 12526 3 - - JJ cord-010092-uftc8inx 12526 4 D d JJ cord-010092-uftc8inx 12526 5 alloantibody alloantibody NN cord-010092-uftc8inx 12526 6 is be VBZ cord-010092-uftc8inx 12526 7 most most RBS cord-010092-uftc8inx 12526 8 frequently frequently RB cord-010092-uftc8inx 12526 9 responsible responsible JJ cord-010092-uftc8inx 12526 10 for for IN cord-010092-uftc8inx 12526 11 the the DT cord-010092-uftc8inx 12526 12 most most RBS cord-010092-uftc8inx 12526 13 serious serious JJ cord-010092-uftc8inx 12526 14 form form NN cord-010092-uftc8inx 12526 15 of of IN cord-010092-uftc8inx 12526 16 HDFN HDFN NNP cord-010092-uftc8inx 12526 17 due due IN cord-010092-uftc8inx 12526 18 to to IN cord-010092-uftc8inx 12526 19 RhD rhd NN cord-010092-uftc8inx 12526 20 incompatibility incompatibility NN cord-010092-uftc8inx 12526 21 ( ( -LRB- cord-010092-uftc8inx 12526 22 RhDi RhDi NNP cord-010092-uftc8inx 12526 23 HDFN HDFN NNP cord-010092-uftc8inx 12526 24 ) ) -RRB- cord-010092-uftc8inx 12526 25 . . . cord-010092-uftc8inx 12527 1 Although although IN cord-010092-uftc8inx 12527 2 immunoprophylaxis immunoprophylaxis NNP cord-010092-uftc8inx 12527 3 ( ( -LRB- cord-010092-uftc8inx 12527 4 IP IP NNP cord-010092-uftc8inx 12527 5 ) ) -RRB- cord-010092-uftc8inx 12527 6 has have VBZ cord-010092-uftc8inx 12527 7 reduced reduce VBN cord-010092-uftc8inx 12527 8 the the DT cord-010092-uftc8inx 12527 9 number number NN cord-010092-uftc8inx 12527 10 of of IN cord-010092-uftc8inx 12527 11 cases case NNS cord-010092-uftc8inx 12527 12 of of IN cord-010092-uftc8inx 12527 13 RhDi RhDi NNP cord-010092-uftc8inx 12527 14 HDFN HDFN NNP cord-010092-uftc8inx 12527 15 , , , cord-010092-uftc8inx 12527 16 this this DT cord-010092-uftc8inx 12527 17 disease disease NN cord-010092-uftc8inx 12527 18 continues continue VBZ cord-010092-uftc8inx 12527 19 to to TO cord-010092-uftc8inx 12527 20 occur occur VB cord-010092-uftc8inx 12527 21 and and CC cord-010092-uftc8inx 12527 22 red red JJ cord-010092-uftc8inx 12527 23 blood blood NN cord-010092-uftc8inx 12527 24 cell cell NN cord-010092-uftc8inx 12527 25 alloimmunization alloimmunization NN cord-010092-uftc8inx 12527 26 still still RB cord-010092-uftc8inx 12527 27 remains remain VBZ cord-010092-uftc8inx 12527 28 the the DT cord-010092-uftc8inx 12527 29 most most RBS cord-010092-uftc8inx 12527 30 common common JJ cord-010092-uftc8inx 12527 31 cause cause NN cord-010092-uftc8inx 12527 32 of of IN cord-010092-uftc8inx 12527 33 foetal foetal JJ cord-010092-uftc8inx 12527 34 anaemia anaemia NN cord-010092-uftc8inx 12527 35 . . . cord-010092-uftc8inx 12528 1 HDFN HDFN NNP cord-010092-uftc8inx 12528 2 due due IN cord-010092-uftc8inx 12528 3 to to IN cord-010092-uftc8inx 12528 4 ABO ABO NNP cord-010092-uftc8inx 12528 5 incompatibility incompatibility NN cord-010092-uftc8inx 12528 6 ( ( -LRB- cord-010092-uftc8inx 12528 7 AB0i AB0i NNP cord-010092-uftc8inx 12528 8 HDFN HDFN NNP cord-010092-uftc8inx 12528 9 ) ) -RRB- cord-010092-uftc8inx 12528 10 is be VBZ cord-010092-uftc8inx 12528 11 currently currently RB cord-010092-uftc8inx 12528 12 the the DT cord-010092-uftc8inx 12528 13 most most RBS cord-010092-uftc8inx 12528 14 common common JJ cord-010092-uftc8inx 12528 15 neonatal neonatal JJ cord-010092-uftc8inx 12528 16 haemolytic haemolytic JJ cord-010092-uftc8inx 12528 17 disease disease NN cord-010092-uftc8inx 12528 18 in in IN cord-010092-uftc8inx 12528 19 the the DT cord-010092-uftc8inx 12528 20 western western JJ cord-010092-uftc8inx 12528 21 world world NN cord-010092-uftc8inx 12528 22 . . . cord-010092-uftc8inx 12529 1 However however RB cord-010092-uftc8inx 12529 2 , , , cord-010092-uftc8inx 12529 3 only only RB cord-010092-uftc8inx 12529 4 in in IN cord-010092-uftc8inx 12529 5 about about RB cord-010092-uftc8inx 12529 6 1.5 1.5 CD cord-010092-uftc8inx 12529 7 - - SYM cord-010092-uftc8inx 12529 8 2 2 CD cord-010092-uftc8inx 12529 9 % % NN cord-010092-uftc8inx 12529 10 of of IN cord-010092-uftc8inx 12529 11 cases case NNS cord-010092-uftc8inx 12529 12 haemolytic haemolytic JJ cord-010092-uftc8inx 12529 13 disease disease NN cord-010092-uftc8inx 12529 14 demands demand VBZ cord-010092-uftc8inx 12529 15 transfusion transfusion NN cord-010092-uftc8inx 12529 16 support support NN cord-010092-uftc8inx 12529 17 . . . cord-010092-uftc8inx 12530 1 Aims aim VBZ cord-010092-uftc8inx 12530 2 : : : cord-010092-uftc8inx 12531 1 Analysis analysis NN cord-010092-uftc8inx 12531 2 HDFN HDFN NNP cord-010092-uftc8inx 12531 3 from from IN cord-010092-uftc8inx 12531 4 2011 2011 CD cord-010092-uftc8inx 12531 5 to to IN cord-010092-uftc8inx 12531 6 2018 2018 CD cord-010092-uftc8inx 12531 7 . . . cord-010092-uftc8inx 12532 1 Methods method NNS cord-010092-uftc8inx 12532 2 : : : cord-010092-uftc8inx 12532 3 The the DT cord-010092-uftc8inx 12532 4 HDFN HDFN NNP cord-010092-uftc8inx 12532 5 's 's POS cord-010092-uftc8inx 12532 6 transfusional transfusional JJ cord-010092-uftc8inx 12532 7 support support NN cord-010092-uftc8inx 12532 8 is be VBZ cord-010092-uftc8inx 12532 9 : : : cord-010092-uftc8inx 12532 10 intrauterine intrauterine JJ cord-010092-uftc8inx 12532 11 transfusion transfusion NN cord-010092-uftc8inx 12532 12 ( ( -LRB- cord-010092-uftc8inx 12532 13 IUT IUT NNP cord-010092-uftc8inx 12532 14 ) ) -RRB- cord-010092-uftc8inx 12532 15 in in IN cord-010092-uftc8inx 12532 16 the the DT cord-010092-uftc8inx 12532 17 antenatal antenatal JJ cord-010092-uftc8inx 12532 18 period period NN cord-010092-uftc8inx 12532 19 ; ; : cord-010092-uftc8inx 12532 20 exchange exchange NN cord-010092-uftc8inx 12532 21 transfusion transfusion NN cord-010092-uftc8inx 12532 22 ( ( -LRB- cord-010092-uftc8inx 12532 23 ET ET NNP cord-010092-uftc8inx 12532 24 ) ) -RRB- cord-010092-uftc8inx 12532 25 for for IN cord-010092-uftc8inx 12532 26 severe severe JJ cord-010092-uftc8inx 12532 27 hyperbilirubinaemia hyperbilirubinaemia NN cord-010092-uftc8inx 12532 28 and and CC cord-010092-uftc8inx 12532 29 neonatal neonatal JJ cord-010092-uftc8inx 12532 30 transfusion transfusion NN cord-010092-uftc8inx 12532 31 of of IN cord-010092-uftc8inx 12532 32 small small JJ cord-010092-uftc8inx 12532 33 volumes volume NNS cord-010092-uftc8inx 12532 34 red red JJ cord-010092-uftc8inx 12532 35 cells cell NNS cord-010092-uftc8inx 12532 36 for for IN cord-010092-uftc8inx 12532 37 the the DT cord-010092-uftc8inx 12532 38 newborn newborn NN cord-010092-uftc8inx 12532 39 's 's POS cord-010092-uftc8inx 12532 40 late late JJ cord-010092-uftc8inx 12532 41 anaemia anaemia NN cord-010092-uftc8inx 12532 42 in in IN cord-010092-uftc8inx 12532 43 the the DT cord-010092-uftc8inx 12532 44 postnatal postnatal JJ cord-010092-uftc8inx 12532 45 period period NN cord-010092-uftc8inx 12532 46 . . . cord-010092-uftc8inx 12533 1 Our -PRON- PRP$ cord-010092-uftc8inx 12533 2 policy policy NN cord-010092-uftc8inx 12533 3 for for IN cord-010092-uftc8inx 12533 4 IUT IUT NNP cord-010092-uftc8inx 12533 5 , , , cord-010092-uftc8inx 12533 6 for for IN cord-010092-uftc8inx 12533 7 ET ET NNP cord-010092-uftc8inx 12533 8 and and CC cord-010092-uftc8inx 12533 9 for for IN cord-010092-uftc8inx 12533 10 the the DT cord-010092-uftc8inx 12533 11 neonatal neonatal JJ cord-010092-uftc8inx 12533 12 transfusion transfusion NN cord-010092-uftc8inx 12533 13 requires require VBZ cord-010092-uftc8inx 12533 14 the the DT cord-010092-uftc8inx 12533 15 use use NN cord-010092-uftc8inx 12533 16 of of IN cord-010092-uftc8inx 12533 17 a a DT cord-010092-uftc8inx 12533 18 concentrated concentrated JJ cord-010092-uftc8inx 12533 19 blood blood NN cord-010092-uftc8inx 12533 20 cells cell NNS cord-010092-uftc8inx 12533 21 ( ( -LRB- cord-010092-uftc8inx 12533 22 EC EC NNP cord-010092-uftc8inx 12533 23 ) ) -RRB- cord-010092-uftc8inx 12533 24 preferably preferably RB cord-010092-uftc8inx 12533 25 group group NN cord-010092-uftc8inx 12533 26 0 0 CD cord-010092-uftc8inx 12534 1 Rh Rh NNP cord-010092-uftc8inx 12534 2 negative negative JJ cord-010092-uftc8inx 12534 3 ( ( -LRB- cord-010092-uftc8inx 12534 4 cde cde NNP cord-010092-uftc8inx 12534 5 / / SYM cord-010092-uftc8inx 12534 6 cde cde NN cord-010092-uftc8inx 12534 7 ) ) -RRB- cord-010092-uftc8inx 12534 8 or or CC cord-010092-uftc8inx 12534 9 negative negative JJ cord-010092-uftc8inx 12534 10 for for IN cord-010092-uftc8inx 12534 11 any any DT cord-010092-uftc8inx 12534 12 red red JJ cord-010092-uftc8inx 12534 13 cell cell NN cord-010092-uftc8inx 12534 14 antigens antigen NNS cord-010092-uftc8inx 12534 15 if if IN cord-010092-uftc8inx 12534 16 the the DT cord-010092-uftc8inx 12534 17 mother mother NN cord-010092-uftc8inx 12534 18 has have VBZ cord-010092-uftc8inx 12534 19 antibodies antibody NNS cord-010092-uftc8inx 12534 20 , , , cord-010092-uftc8inx 12534 21 fresh fresh JJ cord-010092-uftc8inx 12534 22 ( ( -LRB- cord-010092-uftc8inx 12534 23 < < NNP cord-010092-uftc8inx 12534 24 5 5 CD cord-010092-uftc8inx 12534 25 days day NNS cord-010092-uftc8inx 12534 26 ) ) -RRB- cord-010092-uftc8inx 12534 27 , , , cord-010092-uftc8inx 12534 28 preferably preferably RB cord-010092-uftc8inx 12534 29 CMV CMV NNP cord-010092-uftc8inx 12534 30 safe safe JJ cord-010092-uftc8inx 12534 31 . . . cord-010092-uftc8inx 12535 1 For for IN cord-010092-uftc8inx 12535 2 IUT IUT NNP cord-010092-uftc8inx 12535 3 , , , cord-010092-uftc8inx 12535 4 the the DT cord-010092-uftc8inx 12535 5 EC EC NNP cord-010092-uftc8inx 12535 6 must must MD cord-010092-uftc8inx 12535 7 be be VB cord-010092-uftc8inx 12535 8 compatible compatible JJ cord-010092-uftc8inx 12535 9 with with IN cord-010092-uftc8inx 12535 10 mother mother NN cord-010092-uftc8inx 12535 11 's 's POS cord-010092-uftc8inx 12535 12 plasma plasma NN cord-010092-uftc8inx 12535 13 , , , cord-010092-uftc8inx 12535 14 must must MD cord-010092-uftc8inx 12535 15 have have VB cord-010092-uftc8inx 12535 16 hematocrit hematocrit NN cord-010092-uftc8inx 12535 17 70 70 CD cord-010092-uftc8inx 12535 18 + + SYM cord-010092-uftc8inx 12535 19 5 5 CD cord-010092-uftc8inx 12535 20 % % NN cord-010092-uftc8inx 12535 21 , , , cord-010092-uftc8inx 12535 22 and and CC cord-010092-uftc8inx 12535 23 irradiated irradiate VBN cord-010092-uftc8inx 12535 24 . . . cord-010092-uftc8inx 12536 1 The the DT cord-010092-uftc8inx 12536 2 unit unit NN cord-010092-uftc8inx 12536 3 for for IN cord-010092-uftc8inx 12536 4 ET ET NNP cord-010092-uftc8inx 12536 5 must must MD cord-010092-uftc8inx 12536 6 be be VB cord-010092-uftc8inx 12536 7 compatible compatible JJ cord-010092-uftc8inx 12536 8 with with IN cord-010092-uftc8inx 12536 9 the the DT cord-010092-uftc8inx 12536 10 newborn newborn NN cord-010092-uftc8inx 12536 11 's 's POS cord-010092-uftc8inx 12536 12 plasma plasma NN cord-010092-uftc8inx 12536 13 , , , cord-010092-uftc8inx 12536 14 whit whit NNP cord-010092-uftc8inx 12536 15 hematocrit hematocrit NN cord-010092-uftc8inx 12536 16 40 40 CD cord-010092-uftc8inx 12536 17 % % NN cord-010092-uftc8inx 12536 18 -60 -60 NNS cord-010092-uftc8inx 12536 19 % % NN cord-010092-uftc8inx 12536 20 and and CC cord-010092-uftc8inx 12536 21 irradiated irradiate VBN cord-010092-uftc8inx 12536 22 . . . cord-010092-uftc8inx 12537 1 The the DT cord-010092-uftc8inx 12537 2 EC EC NNP cord-010092-uftc8inx 12537 3 used use VBD cord-010092-uftc8inx 12537 4 in in IN cord-010092-uftc8inx 12537 5 post post JJ cord-010092-uftc8inx 12537 6 - - JJ cord-010092-uftc8inx 12537 7 natal natal JJ cord-010092-uftc8inx 12537 8 transfusions transfusion NNS cord-010092-uftc8inx 12537 9 is be VBZ cord-010092-uftc8inx 12537 10 usually usually RB cord-010092-uftc8inx 12537 11 divided divide VBN cord-010092-uftc8inx 12537 12 into into IN cord-010092-uftc8inx 12537 13 rates rate NNS cord-010092-uftc8inx 12537 14 of of IN cord-010092-uftc8inx 12537 15 70 70 CD cord-010092-uftc8inx 12537 16 mL ml NN cord-010092-uftc8inx 12537 17 , , , cord-010092-uftc8inx 12537 18 hematocrit hematocrit NN cord-010092-uftc8inx 12537 19 55 55 CD cord-010092-uftc8inx 12537 20 AE AE NNP cord-010092-uftc8inx 12537 21 5 5 CD cord-010092-uftc8inx 12537 22 % % NN cord-010092-uftc8inx 12537 23 . . . cord-010092-uftc8inx 12538 1 Results result NNS cord-010092-uftc8inx 12538 2 : : : cord-010092-uftc8inx 12539 1 In in IN cord-010092-uftc8inx 12539 2 last last JJ cord-010092-uftc8inx 12539 3 7 7 CD cord-010092-uftc8inx 12539 4 years year NNS cord-010092-uftc8inx 12539 5 , , , cord-010092-uftc8inx 12539 6 we -PRON- PRP cord-010092-uftc8inx 12539 7 calculated calculate VBD cord-010092-uftc8inx 12539 8 59 59 CD cord-010092-uftc8inx 12539 9 neonates neonate NNS cord-010092-uftc8inx 12539 10 with with IN cord-010092-uftc8inx 12539 11 HDFN HDFN NNP cord-010092-uftc8inx 12539 12 ( ( -LRB- cord-010092-uftc8inx 12539 13 28 28 CD cord-010092-uftc8inx 12539 14 males male NNS cord-010092-uftc8inx 12539 15 and and CC cord-010092-uftc8inx 12539 16 31 31 CD cord-010092-uftc8inx 12539 17 females female NNS cord-010092-uftc8inx 12539 18 ) ) -RRB- cord-010092-uftc8inx 12539 19 : : : cord-010092-uftc8inx 12539 20 31 31 CD cord-010092-uftc8inx 12539 21 with with IN cord-010092-uftc8inx 12539 22 RhDi RhDi NNP cord-010092-uftc8inx 12539 23 HDFN HDFN NNP cord-010092-uftc8inx 12539 24 , , , cord-010092-uftc8inx 12539 25 19 19 CD cord-010092-uftc8inx 12539 26 with with IN cord-010092-uftc8inx 12539 27 AB0i AB0i NNP cord-010092-uftc8inx 12539 28 HDFN HDFN NNP cord-010092-uftc8inx 12539 29 and and CC cord-010092-uftc8inx 12539 30 9 9 CD cord-010092-uftc8inx 12539 31 with with IN cord-010092-uftc8inx 12539 32 HDFN HDFN NNP cord-010092-uftc8inx 12539 33 due due IN cord-010092-uftc8inx 12539 34 to to IN cord-010092-uftc8inx 12539 35 incompatibility incompatibility NN cord-010092-uftc8inx 12539 36 for for IN cord-010092-uftc8inx 12539 37 other other JJ cord-010092-uftc8inx 12539 38 red red JJ cord-010092-uftc8inx 12539 39 blood blood NN cord-010092-uftc8inx 12539 40 cell cell NN cord-010092-uftc8inx 12539 41 antigens antigen NNS cord-010092-uftc8inx 12539 42 . . . cord-010092-uftc8inx 12540 1 We -PRON- PRP cord-010092-uftc8inx 12540 2 have have VBP cord-010092-uftc8inx 12540 3 produced produce VBN cord-010092-uftc8inx 12540 4 81 81 CD cord-010092-uftc8inx 12540 5 IUT IUT NNP cord-010092-uftc8inx 12540 6 : : : cord-010092-uftc8inx 12540 7 48 48 CD cord-010092-uftc8inx 12540 8 for for IN cord-010092-uftc8inx 12540 9 our -PRON- PRP$ cord-010092-uftc8inx 12540 10 hospitalized hospitalize VBN cord-010092-uftc8inx 12540 11 patients patient NNS cord-010092-uftc8inx 12540 12 and and CC cord-010092-uftc8inx 12540 13 33 33 CD cord-010092-uftc8inx 12540 14 for for IN cord-010092-uftc8inx 12540 15 patients patient NNS cord-010092-uftc8inx 12540 16 located locate VBN cord-010092-uftc8inx 12540 17 in in IN cord-010092-uftc8inx 12540 18 other other JJ cord-010092-uftc8inx 12540 19 hospitals hospital NNS cord-010092-uftc8inx 12540 20 . . . cord-010092-uftc8inx 12541 1 25 25 CD cord-010092-uftc8inx 12541 2 of of IN cord-010092-uftc8inx 12541 3 these these DT cord-010092-uftc8inx 12541 4 48 48 CD cord-010092-uftc8inx 12541 5 patients patient NNS cord-010092-uftc8inx 12541 6 , , , cord-010092-uftc8inx 12541 7 who who WP cord-010092-uftc8inx 12541 8 received receive VBD cord-010092-uftc8inx 12541 9 IUT IUT NNP cord-010092-uftc8inx 12541 10 , , , cord-010092-uftc8inx 12541 11 were be VBD cord-010092-uftc8inx 12541 12 immunized immunize VBN cord-010092-uftc8inx 12541 13 : : : cord-010092-uftc8inx 12541 14 19 19 CD cord-010092-uftc8inx 12541 15 showed show VBD cord-010092-uftc8inx 12541 16 anti anti JJ cord-010092-uftc8inx 12541 17 - - JJ cord-010092-uftc8inx 12541 18 D d JJ cord-010092-uftc8inx 12541 19 antibody antibody NN cord-010092-uftc8inx 12541 20 and and CC cord-010092-uftc8inx 12541 21 6 6 CD cord-010092-uftc8inx 12541 22 antibodies antibody NNS cord-010092-uftc8inx 12541 23 different different JJ cord-010092-uftc8inx 12541 24 from from IN cord-010092-uftc8inx 12541 25 anti anti JJ cord-010092-uftc8inx 12541 26 - - JJ cord-010092-uftc8inx 12541 27 A a JJ cord-010092-uftc8inx 12541 28 and and CC cord-010092-uftc8inx 12541 29 anti anti JJ cord-010092-uftc8inx 12541 30 - - JJ cord-010092-uftc8inx 12541 31 B. B. NNP cord-010092-uftc8inx 12541 32 7 7 CD cord-010092-uftc8inx 12541 33 , , , cord-010092-uftc8inx 12541 34 of of IN cord-010092-uftc8inx 12541 35 the the DT cord-010092-uftc8inx 12541 36 31 31 CD cord-010092-uftc8inx 12541 37 infants infant NNS cord-010092-uftc8inx 12541 38 with with IN cord-010092-uftc8inx 12541 39 RhDi RhDi NNP cord-010092-uftc8inx 12541 40 HDFN HDFN NNP cord-010092-uftc8inx 12541 41 , , , cord-010092-uftc8inx 12541 42 were be VBD cord-010092-uftc8inx 12541 43 transfused transfuse VBN cord-010092-uftc8inx 12541 44 in in IN cord-010092-uftc8inx 12541 45 utero utero NNS cord-010092-uftc8inx 12541 46 . . . cord-010092-uftc8inx 12542 1 4 4 LS cord-010092-uftc8inx 12542 2 neonates neonate NNS cord-010092-uftc8inx 12542 3 on on IN cord-010092-uftc8inx 12542 4 59 59 CD cord-010092-uftc8inx 12542 5 ( ( -LRB- cord-010092-uftc8inx 12542 6 6.8 6.8 CD cord-010092-uftc8inx 12542 7 % % NN cord-010092-uftc8inx 12542 8 ) ) -RRB- cord-010092-uftc8inx 12542 9 have have VBP cord-010092-uftc8inx 12542 10 performed perform VBN cord-010092-uftc8inx 12542 11 ET et NN cord-010092-uftc8inx 12542 12 : : : cord-010092-uftc8inx 12542 13 1 1 CD cord-010092-uftc8inx 12542 14 with with IN cord-010092-uftc8inx 12542 15 AB0i AB0i NNP cord-010092-uftc8inx 12542 16 HDFN HDFN NNP cord-010092-uftc8inx 12542 17 and and CC cord-010092-uftc8inx 12542 18 3 3 CD cord-010092-uftc8inx 12542 19 with with IN cord-010092-uftc8inx 12542 20 RhDi RhDi NNP cord-010092-uftc8inx 12542 21 HDFN HDFN NNP cord-010092-uftc8inx 12542 22 ; ; : cord-010092-uftc8inx 12542 23 the the DT cord-010092-uftc8inx 12542 24 latter latter JJ cord-010092-uftc8inx 12542 25 had have VBD cord-010092-uftc8inx 12542 26 also also RB cord-010092-uftc8inx 12542 27 been be VBN cord-010092-uftc8inx 12542 28 transfused transfuse VBN cord-010092-uftc8inx 12542 29 in in IN cord-010092-uftc8inx 12542 30 utero utero NNS cord-010092-uftc8inx 12542 31 . . . cord-010092-uftc8inx 12543 1 27 27 CD cord-010092-uftc8inx 12543 2 neonates neonate NNS cord-010092-uftc8inx 12543 3 on on IN cord-010092-uftc8inx 12543 4 59 59 CD cord-010092-uftc8inx 12543 5 were be VBD cord-010092-uftc8inx 12543 6 transfused transfuse VBN cord-010092-uftc8inx 12543 7 after after IN cord-010092-uftc8inx 12543 8 birth birth NN cord-010092-uftc8inx 12543 9 : : : cord-010092-uftc8inx 12543 10 18 18 CD cord-010092-uftc8inx 12543 11 with with IN cord-010092-uftc8inx 12543 12 RhDi RhDi NNP cord-010092-uftc8inx 12543 13 HDFN HDFN NNP cord-010092-uftc8inx 12543 14 , , , cord-010092-uftc8inx 12543 15 3 3 CD cord-010092-uftc8inx 12543 16 with with IN cord-010092-uftc8inx 12543 17 AB0i AB0i NNP cord-010092-uftc8inx 12543 18 HDFN HDFN NNP cord-010092-uftc8inx 12543 19 and and CC cord-010092-uftc8inx 12543 20 6 6 CD cord-010092-uftc8inx 12543 21 with with IN cord-010092-uftc8inx 12543 22 HDFN HDFN NNP cord-010092-uftc8inx 12543 23 due due IN cord-010092-uftc8inx 12543 24 to to IN cord-010092-uftc8inx 12543 25 incompatibility incompatibility NN cord-010092-uftc8inx 12543 26 for for IN cord-010092-uftc8inx 12543 27 other other JJ cord-010092-uftc8inx 12543 28 antigens antigen NNS cord-010092-uftc8inx 12543 29 . . . cord-010092-uftc8inx 12544 1 Summary Summary NNP cord-010092-uftc8inx 12544 2 / / SYM cord-010092-uftc8inx 12544 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 12544 4 : : : cord-010092-uftc8inx 12545 1 Our -PRON- PRP$ cord-010092-uftc8inx 12545 2 case case NN cord-010092-uftc8inx 12545 3 studies study NNS cord-010092-uftc8inx 12545 4 reflect reflect VBP cord-010092-uftc8inx 12545 5 the the DT cord-010092-uftc8inx 12545 6 literature literature NN cord-010092-uftc8inx 12545 7 data datum NNS cord-010092-uftc8inx 12545 8 . . . cord-010092-uftc8inx 12546 1 Neonates Neonates NNP cord-010092-uftc8inx 12546 2 with with IN cord-010092-uftc8inx 12546 3 RhDi RhDi NNP cord-010092-uftc8inx 12546 4 HDFN HDFN NNP cord-010092-uftc8inx 12546 5 are be VBP cord-010092-uftc8inx 12546 6 the the DT cord-010092-uftc8inx 12546 7 most most RBS cord-010092-uftc8inx 12546 8 numerous numerous JJ cord-010092-uftc8inx 12546 9 ( ( -LRB- cord-010092-uftc8inx 12546 10 52.7 52.7 CD cord-010092-uftc8inx 12546 11 % % NN cord-010092-uftc8inx 12546 12 of of IN cord-010092-uftc8inx 12546 13 the the DT cord-010092-uftc8inx 12546 14 total total NN cord-010092-uftc8inx 12546 15 ) ) -RRB- cord-010092-uftc8inx 12546 16 and and CC cord-010092-uftc8inx 12546 17 are be VBP cord-010092-uftc8inx 12546 18 those those DT cord-010092-uftc8inx 12546 19 who who WP cord-010092-uftc8inx 12546 20 have have VBP cord-010092-uftc8inx 12546 21 requested request VBN cord-010092-uftc8inx 12546 22 the the DT cord-010092-uftc8inx 12546 23 highest high JJS cord-010092-uftc8inx 12546 24 blood blood NN cord-010092-uftc8inx 12546 25 supply supply NN cord-010092-uftc8inx 12546 26 both both DT cord-010092-uftc8inx 12546 27 in in IN cord-010092-uftc8inx 12546 28 the the DT cord-010092-uftc8inx 12546 29 antenatal antenatal JJ cord-010092-uftc8inx 12546 30 period period NN cord-010092-uftc8inx 12546 31 ( ( -LRB- cord-010092-uftc8inx 12546 32 39.6 39.6 CD cord-010092-uftc8inx 12546 33 % % NN cord-010092-uftc8inx 12546 34 ) ) -RRB- cord-010092-uftc8inx 12546 35 that that IN cord-010092-uftc8inx 12546 36 postnatal postnatal NN cord-010092-uftc8inx 12546 37 ( ( -LRB- cord-010092-uftc8inx 12546 38 9.6 9.6 CD cord-010092-uftc8inx 12546 39 % % NN cord-010092-uftc8inx 12546 40 performs perform VBZ cord-010092-uftc8inx 12546 41 ET ET NNP cord-010092-uftc8inx 12546 42 , , , cord-010092-uftc8inx 12546 43 66.6 66.6 CD cord-010092-uftc8inx 12546 44 % % NN cord-010092-uftc8inx 12546 45 performs perform VBZ cord-010092-uftc8inx 12546 46 postnatal postnatal JJ cord-010092-uftc8inx 12546 47 transfusions transfusion NNS cord-010092-uftc8inx 12546 48 ) ) -RRB- cord-010092-uftc8inx 12546 49 . . . cord-010092-uftc8inx 12547 1 Neonates Neonates NNP cord-010092-uftc8inx 12547 2 with with IN cord-010092-uftc8inx 12547 3 ABOi ABOi NNS cord-010092-uftc8inx 12547 4 HDFN HDFN NNP cord-010092-uftc8inx 12547 5 are be VBP cord-010092-uftc8inx 12547 6 32.3 32.3 CD cord-010092-uftc8inx 12547 7 % % NN cord-010092-uftc8inx 12547 8 : : : cord-010092-uftc8inx 12547 9 nobody nobody NN cord-010092-uftc8inx 12547 10 has have VBZ cord-010092-uftc8inx 12547 11 received receive VBN cord-010092-uftc8inx 12547 12 IUT IUT NNP cord-010092-uftc8inx 12547 13 , , , cord-010092-uftc8inx 12547 14 only only RB cord-010092-uftc8inx 12547 15 one one CD cord-010092-uftc8inx 12547 16 has have VBZ cord-010092-uftc8inx 12547 17 been be VBN cord-010092-uftc8inx 12547 18 subjected subject VBN cord-010092-uftc8inx 12547 19 to to IN cord-010092-uftc8inx 12547 20 ET ET NNP cord-010092-uftc8inx 12547 21 , , , cord-010092-uftc8inx 12547 22 and and CC cord-010092-uftc8inx 12547 23 11 11 CD cord-010092-uftc8inx 12547 24 % % NN cord-010092-uftc8inx 12547 25 has have VBZ cord-010092-uftc8inx 12547 26 transfused transfuse VBN cord-010092-uftc8inx 12547 27 after after IN cord-010092-uftc8inx 12547 28 birth birth NN cord-010092-uftc8inx 12547 29 . . . cord-010092-uftc8inx 12548 1 Patients patient NNS cord-010092-uftc8inx 12548 2 with with IN cord-010092-uftc8inx 12548 3 HDFN HDFN NNP cord-010092-uftc8inx 12548 4 due due IN cord-010092-uftc8inx 12548 5 to to IN cord-010092-uftc8inx 12548 6 other other JJ cord-010092-uftc8inx 12548 7 antigens antigen NNS cord-010092-uftc8inx 12548 8 are be VBP cord-010092-uftc8inx 12548 9 15 15 CD cord-010092-uftc8inx 12548 10 % % NN cord-010092-uftc8inx 12548 11 , , , cord-010092-uftc8inx 12548 12 have have VBP cord-010092-uftc8inx 12548 13 undergone undergo VBN cord-010092-uftc8inx 12548 14 IUT IUT NNP cord-010092-uftc8inx 12548 15 12.5 12.5 CD cord-010092-uftc8inx 12548 16 % % NN cord-010092-uftc8inx 12548 17 and and CC cord-010092-uftc8inx 12548 18 were be VBD cord-010092-uftc8inx 12548 19 transfused transfuse VBN cord-010092-uftc8inx 12548 20 after after IN cord-010092-uftc8inx 12548 21 birth birth NN cord-010092-uftc8inx 12548 22 22.2 22.2 CD cord-010092-uftc8inx 12548 23 % % NN cord-010092-uftc8inx 12548 24 . . . cord-010092-uftc8inx 12549 1 Background background NN cord-010092-uftc8inx 12549 2 : : : cord-010092-uftc8inx 12550 1 According accord VBG cord-010092-uftc8inx 12550 2 to to IN cord-010092-uftc8inx 12550 3 British British NNP cord-010092-uftc8inx 12550 4 Guidelines Guidelines NNPS cord-010092-uftc8inx 12550 5 on on IN cord-010092-uftc8inx 12550 6 Neonatal Neonatal NNP cord-010092-uftc8inx 12550 7 Transfusion Transfusion NNP cord-010092-uftc8inx 12550 8 , , , cord-010092-uftc8inx 12550 9 since since IN cord-010092-uftc8inx 12550 10 2012 2012 CD cord-010092-uftc8inx 12550 11 we -PRON- PRP cord-010092-uftc8inx 12550 12 shared share VBD cord-010092-uftc8inx 12550 13 with with IN cord-010092-uftc8inx 12550 14 neonatologists neonatologist NNS cord-010092-uftc8inx 12550 15 a a DT cord-010092-uftc8inx 12550 16 transfusion transfusion NN cord-010092-uftc8inx 12550 17 protocol protocol NN cord-010092-uftc8inx 12550 18 for for IN cord-010092-uftc8inx 12550 19 preterm preterm JJ cord-010092-uftc8inx 12550 20 babies baby NNS cord-010092-uftc8inx 12550 21 . . . cord-010092-uftc8inx 12551 1 Patients patient NNS cord-010092-uftc8inx 12551 2 are be VBP cord-010092-uftc8inx 12551 3 anemic anemic JJ cord-010092-uftc8inx 12551 4 premature premature JJ cord-010092-uftc8inx 12551 5 newborns newborn NNS cord-010092-uftc8inx 12551 6 with with IN cord-010092-uftc8inx 12551 7 a a DT cord-010092-uftc8inx 12551 8 gestational gestational JJ cord-010092-uftc8inx 12551 9 age age NN cord-010092-uftc8inx 12551 10 ≤ ≤ NNS cord-010092-uftc8inx 12551 11 30 30 CD cord-010092-uftc8inx 12551 12 weeks week NNS cord-010092-uftc8inx 12551 13 and/or and/or CC cord-010092-uftc8inx 12551 14 a a DT cord-010092-uftc8inx 12551 15 birthweight birthweight JJ cord-010092-uftc8inx 12551 16 lower low JJR cord-010092-uftc8inx 12551 17 than than IN cord-010092-uftc8inx 12551 18 1500 1500 CD cord-010092-uftc8inx 12551 19 g g NN cord-010092-uftc8inx 12551 20 , , , cord-010092-uftc8inx 12551 21 until until IN cord-010092-uftc8inx 12551 22 4 4 CD cord-010092-uftc8inx 12551 23 months month NNS cord-010092-uftc8inx 12551 24 of of IN cord-010092-uftc8inx 12551 25 age age NN cord-010092-uftc8inx 12551 26 . . . cord-010092-uftc8inx 12552 1 Aims aim VBZ cord-010092-uftc8inx 12552 2 : : : cord-010092-uftc8inx 12553 1 Reduce reduce VB cord-010092-uftc8inx 12553 2 the the DT cord-010092-uftc8inx 12553 3 incidence incidence NN cord-010092-uftc8inx 12553 4 of of IN cord-010092-uftc8inx 12553 5 iatrogenic iatrogenic JJ cord-010092-uftc8inx 12553 6 anemia anemia NN cord-010092-uftc8inx 12553 7 . . . cord-010092-uftc8inx 12554 1 Methods method NNS cord-010092-uftc8inx 12554 2 : : : cord-010092-uftc8inx 12555 1 Pre pre JJ cord-010092-uftc8inx 12555 2 - - JJ cord-010092-uftc8inx 12555 3 transfusion transfusion NN cord-010092-uftc8inx 12555 4 tests test NNS cord-010092-uftc8inx 12555 5 were be VBD cord-010092-uftc8inx 12555 6 based base VBN cord-010092-uftc8inx 12555 7 on on IN cord-010092-uftc8inx 12555 8 AB0 AB0 VBG cord-010092-uftc8inx 12555 9 direct direct JJ cord-010092-uftc8inx 12555 10 test test NN cord-010092-uftc8inx 12555 11 , , , cord-010092-uftc8inx 12555 12 Rh Rh NNP cord-010092-uftc8inx 12555 13 phenotype phenotype NN cord-010092-uftc8inx 12555 14 , , , cord-010092-uftc8inx 12555 15 direct direct JJ cord-010092-uftc8inx 12555 16 and and CC cord-010092-uftc8inx 12555 17 indirect indirect JJ cord-010092-uftc8inx 12555 18 antiglobulin antiglobulin NN cord-010092-uftc8inx 12555 19 test test NN cord-010092-uftc8inx 12555 20 ( ( -LRB- cord-010092-uftc8inx 12555 21 DAT DAT NNP cord-010092-uftc8inx 12555 22 , , , cord-010092-uftc8inx 12555 23 IAT IAT NNP cord-010092-uftc8inx 12555 24 ) ) -RRB- cord-010092-uftc8inx 12555 25 . . . cord-010092-uftc8inx 12556 1 A a DT cord-010092-uftc8inx 12556 2 second second JJ cord-010092-uftc8inx 12556 3 blood blood NN cord-010092-uftc8inx 12556 4 sample sample NN cord-010092-uftc8inx 12556 5 was be VBD cord-010092-uftc8inx 12556 6 required require VBN cord-010092-uftc8inx 12556 7 for for IN cord-010092-uftc8inx 12556 8 AB0 AB0 NNP cord-010092-uftc8inx 12556 9 / / SYM cord-010092-uftc8inx 12556 10 Rh Rh NNP cord-010092-uftc8inx 12556 11 confirmation confirmation NN cord-010092-uftc8inx 12556 12 . . . cord-010092-uftc8inx 12557 1 Blood blood NN cord-010092-uftc8inx 12557 2 transfusions transfusion NNS cord-010092-uftc8inx 12557 3 were be VBD cord-010092-uftc8inx 12557 4 performed perform VBN cord-010092-uftc8inx 12557 5 with with IN cord-010092-uftc8inx 12557 6 0 0 CD cord-010092-uftc8inx 12557 7 negative negative JJ cord-010092-uftc8inx 12557 8 Kell Kell NNP cord-010092-uftc8inx 12557 9 negative negative JJ cord-010092-uftc8inx 12557 10 ( ( -LRB- cord-010092-uftc8inx 12557 11 0 0 CD cord-010092-uftc8inx 12557 12 cde cde NNP cord-010092-uftc8inx 12557 13 / / SYM cord-010092-uftc8inx 12557 14 cde cde NNP cord-010092-uftc8inx 12557 15 / / SYM cord-010092-uftc8inx 12557 16 kk kk NNP cord-010092-uftc8inx 12557 17 ) ) -RRB- cord-010092-uftc8inx 12557 18 CMV CMV NNP cord-010092-uftc8inx 12557 19 negative negative JJ cord-010092-uftc8inx 12557 20 irradiated irradiate VBN cord-010092-uftc8inx 12557 21 erythrocyte erythrocyte NN cord-010092-uftc8inx 12557 22 concentrates concentrate NNS cord-010092-uftc8inx 12557 23 ( ( -LRB- cord-010092-uftc8inx 12557 24 EC EC NNP cord-010092-uftc8inx 12557 25 ) ) -RRB- cord-010092-uftc8inx 12557 26 of of IN cord-010092-uftc8inx 12557 27 less less JJR cord-010092-uftc8inx 12557 28 than than IN cord-010092-uftc8inx 12557 29 5 5 CD cord-010092-uftc8inx 12557 30 days day NNS cord-010092-uftc8inx 12557 31 . . . cord-010092-uftc8inx 12558 1 EC EC NNP cord-010092-uftc8inx 12558 2 were be VBD cord-010092-uftc8inx 12558 3 subdivided subdivide VBN cord-010092-uftc8inx 12558 4 in in IN cord-010092-uftc8inx 12558 5 70 70 CD cord-010092-uftc8inx 12558 6 mL ml NN cord-010092-uftc8inx 12558 7 aliquots aliquot NNS cord-010092-uftc8inx 12558 8 with with IN cord-010092-uftc8inx 12558 9 a a DT cord-010092-uftc8inx 12558 10 hematocrit hematocrit NN cord-010092-uftc8inx 12558 11 of of IN cord-010092-uftc8inx 12558 12 55 55 CD cord-010092-uftc8inx 12558 13 AE AE NNP cord-010092-uftc8inx 12558 14 5 5 CD cord-010092-uftc8inx 12558 15 % % NN cord-010092-uftc8inx 12558 16 . . . cord-010092-uftc8inx 12559 1 According accord VBG cord-010092-uftc8inx 12559 2 to to IN cord-010092-uftc8inx 12559 3 the the DT cord-010092-uftc8inx 12559 4 definition definition NN cord-010092-uftc8inx 12559 5 of of IN cord-010092-uftc8inx 12559 6 " " `` cord-010092-uftc8inx 12559 7 small small JJ cord-010092-uftc8inx 12559 8 volume volume NN cord-010092-uftc8inx 12559 9 transfusions transfusion NNS cord-010092-uftc8inx 12559 10 " " '' cord-010092-uftc8inx 12559 11 , , , cord-010092-uftc8inx 12559 12 our -PRON- PRP$ cord-010092-uftc8inx 12559 13 protocol protocol NN cord-010092-uftc8inx 12559 14 established establish VBD cord-010092-uftc8inx 12559 15 that that IN cord-010092-uftc8inx 12559 16 further further JJ cord-010092-uftc8inx 12559 17 four four CD cord-010092-uftc8inx 12559 18 transfusions transfusion NNS cord-010092-uftc8inx 12559 19 had have VBD cord-010092-uftc8inx 12559 20 to to TO cord-010092-uftc8inx 12559 21 be be VB cord-010092-uftc8inx 12559 22 delivered deliver VBN cord-010092-uftc8inx 12559 23 free free JJ cord-010092-uftc8inx 12559 24 of of IN cord-010092-uftc8inx 12559 25 testing testing NN cord-010092-uftc8inx 12559 26 . . . cord-010092-uftc8inx 12560 1 After after IN cord-010092-uftc8inx 12560 2 the the DT cord-010092-uftc8inx 12560 3 fifth fifth JJ cord-010092-uftc8inx 12560 4 EC EC NNP cord-010092-uftc8inx 12560 5 transfusion transfusion NN cord-010092-uftc8inx 12560 6 the the DT cord-010092-uftc8inx 12560 7 supplementary supplementary JJ cord-010092-uftc8inx 12560 8 release release NN cord-010092-uftc8inx 12560 9 of of IN cord-010092-uftc8inx 12560 10 EC EC NNP cord-010092-uftc8inx 12560 11 was be VBD cord-010092-uftc8inx 12560 12 provided provide VBN cord-010092-uftc8inx 12560 13 of of IN cord-010092-uftc8inx 12560 14 Type type NN cord-010092-uftc8inx 12560 15 and and CC cord-010092-uftc8inx 12560 16 Screen Screen NNP cord-010092-uftc8inx 12560 17 ( ( -LRB- cord-010092-uftc8inx 12560 18 T&S t&s NN cord-010092-uftc8inx 12560 19 ) ) -RRB- cord-010092-uftc8inx 12560 20 test test NN cord-010092-uftc8inx 12560 21 with with IN cord-010092-uftc8inx 12560 22 72 72 CD cord-010092-uftc8inx 12560 23 h h NN cord-010092-uftc8inx 12560 24 of of IN cord-010092-uftc8inx 12560 25 validity validity NN cord-010092-uftc8inx 12560 26 . . . cord-010092-uftc8inx 12561 1 Serological serological JJ cord-010092-uftc8inx 12561 2 investigation investigation NN cord-010092-uftc8inx 12561 3 and and CC cord-010092-uftc8inx 12561 4 full full JJ cord-010092-uftc8inx 12561 5 compatibility compatibility NN cord-010092-uftc8inx 12561 6 testing testing NN cord-010092-uftc8inx 12561 7 were be VBD cord-010092-uftc8inx 12561 8 applied apply VBN cord-010092-uftc8inx 12561 9 in in IN cord-010092-uftc8inx 12561 10 the the DT cord-010092-uftc8inx 12561 11 presence presence NN cord-010092-uftc8inx 12561 12 of of IN cord-010092-uftc8inx 12561 13 a a DT cord-010092-uftc8inx 12561 14 IAT IAT NNP cord-010092-uftc8inx 12561 15 and/or and/or CC cord-010092-uftc8inx 12561 16 DAT DAT NNP cord-010092-uftc8inx 12561 17 positivity positivity NN cord-010092-uftc8inx 12561 18 and and CC cord-010092-uftc8inx 12561 19 in in IN cord-010092-uftc8inx 12561 20 the the DT cord-010092-uftc8inx 12561 21 case case NN cord-010092-uftc8inx 12561 22 of of IN cord-010092-uftc8inx 12561 23 mother mother NN cord-010092-uftc8inx 12561 24 alloimmunization alloimmunization NN cord-010092-uftc8inx 12561 25 . . . cord-010092-uftc8inx 12562 1 Results result NNS cord-010092-uftc8inx 12562 2 : : : cord-010092-uftc8inx 12563 1 From from IN cord-010092-uftc8inx 12563 2 October October NNP cord-010092-uftc8inx 12563 3 2012 2012 CD cord-010092-uftc8inx 12563 4 to to IN cord-010092-uftc8inx 12563 5 the the DT cord-010092-uftc8inx 12563 6 end end NN cord-010092-uftc8inx 12563 7 of of IN cord-010092-uftc8inx 12563 8 2018 2018 CD cord-010092-uftc8inx 12563 9 , , , cord-010092-uftc8inx 12563 10 694 694 CD cord-010092-uftc8inx 12563 11 premature premature JJ cord-010092-uftc8inx 12563 12 newborns newborn NNS cord-010092-uftc8inx 12563 13 received receive VBD cord-010092-uftc8inx 12563 14 2328 2328 CD cord-010092-uftc8inx 12563 15 EC EC NNP cord-010092-uftc8inx 12563 16 transfusions transfusion NNS cord-010092-uftc8inx 12563 17 within within IN cord-010092-uftc8inx 12563 18 their -PRON- PRP$ cord-010092-uftc8inx 12563 19 first first JJ cord-010092-uftc8inx 12563 20 4 4 CD cord-010092-uftc8inx 12563 21 months month NNS cord-010092-uftc8inx 12563 22 of of IN cord-010092-uftc8inx 12563 23 life life NN cord-010092-uftc8inx 12563 24 . . . cord-010092-uftc8inx 12564 1 In in IN cord-010092-uftc8inx 12564 2 51 51 CD cord-010092-uftc8inx 12564 3 % % NN cord-010092-uftc8inx 12564 4 of of IN cord-010092-uftc8inx 12564 5 cases case NNS cord-010092-uftc8inx 12564 6 ( ( -LRB- cord-010092-uftc8inx 12564 7 n n NN cord-010092-uftc8inx 12564 8 = = SYM cord-010092-uftc8inx 12564 9 1186 1186 CD cord-010092-uftc8inx 12564 10 ) ) -RRB- cord-010092-uftc8inx 12564 11 , , , cord-010092-uftc8inx 12564 12 transfusion transfusion NN cord-010092-uftc8inx 12564 13 requirement requirement NN cord-010092-uftc8inx 12564 14 was be VBD cord-010092-uftc8inx 12564 15 comprised comprise VBN cord-010092-uftc8inx 12564 16 within within IN cord-010092-uftc8inx 12564 17 the the DT cord-010092-uftc8inx 12564 18 ' ' `` cord-010092-uftc8inx 12564 19 small small JJ cord-010092-uftc8inx 12564 20 volume volume NN cord-010092-uftc8inx 12564 21 transfusions transfusion NNS cord-010092-uftc8inx 12564 22 ' ' '' cord-010092-uftc8inx 12564 23 . . . cord-010092-uftc8inx 12565 1 Another another DT cord-010092-uftc8inx 12565 2 44 44 CD cord-010092-uftc8inx 12565 3 % % NN cord-010092-uftc8inx 12565 4 of of IN cord-010092-uftc8inx 12565 5 cases case NNS cord-010092-uftc8inx 12565 6 ( ( -LRB- cord-010092-uftc8inx 12565 7 n n NN cord-010092-uftc8inx 12565 8 = = SYM cord-010092-uftc8inx 12565 9 1035 1035 CD cord-010092-uftc8inx 12565 10 ) ) -RRB- cord-010092-uftc8inx 12565 11 , , , cord-010092-uftc8inx 12565 12 requiring require VBG cord-010092-uftc8inx 12565 13 further further JJ cord-010092-uftc8inx 12565 14 EC EC NNP cord-010092-uftc8inx 12565 15 administration administration NN cord-010092-uftc8inx 12565 16 , , , cord-010092-uftc8inx 12565 17 was be VBD cord-010092-uftc8inx 12565 18 requested request VBN cord-010092-uftc8inx 12565 19 of of IN cord-010092-uftc8inx 12565 20 a a DT cord-010092-uftc8inx 12565 21 blood blood NN cord-010092-uftc8inx 12565 22 sample sample NN cord-010092-uftc8inx 12565 23 for for IN cord-010092-uftc8inx 12565 24 T&S T&S NNP cord-010092-uftc8inx 12565 25 determination determination NN cord-010092-uftc8inx 12565 26 and and CC cord-010092-uftc8inx 12565 27 5 5 CD cord-010092-uftc8inx 12565 28 % % NN cord-010092-uftc8inx 12565 29 ( ( -LRB- cord-010092-uftc8inx 12565 30 n n NN cord-010092-uftc8inx 12565 31 = = SYM cord-010092-uftc8inx 12565 32 107 107 CD cord-010092-uftc8inx 12565 33 ) ) -RRB- cord-010092-uftc8inx 12565 34 for for IN cord-010092-uftc8inx 12565 35 a a DT cord-010092-uftc8inx 12565 36 cross cross NN cord-010092-uftc8inx 12565 37 - - JJ cord-010092-uftc8inx 12565 38 match match JJ cord-010092-uftc8inx 12565 39 test test NN cord-010092-uftc8inx 12565 40 . . . cord-010092-uftc8inx 12566 1 In in IN cord-010092-uftc8inx 12566 2 79.4 79.4 CD cord-010092-uftc8inx 12566 3 % % NN cord-010092-uftc8inx 12566 4 of of IN cord-010092-uftc8inx 12566 5 newborns newborn NNS cord-010092-uftc8inx 12566 6 ( ( -LRB- cord-010092-uftc8inx 12566 7 n n NN cord-010092-uftc8inx 12566 8 = = SYM cord-010092-uftc8inx 12566 9 551 551 CD cord-010092-uftc8inx 12566 10 ) ) -RRB- cord-010092-uftc8inx 12566 11 , , , cord-010092-uftc8inx 12566 12 being be VBG cord-010092-uftc8inx 12566 13 transfused transfuse VBN cord-010092-uftc8inx 12566 14 within within IN cord-010092-uftc8inx 12566 15 the the DT cord-010092-uftc8inx 12566 16 " " `` cord-010092-uftc8inx 12566 17 small small JJ cord-010092-uftc8inx 12566 18 volume volume NN cord-010092-uftc8inx 12566 19 transfusions transfusion NNS cord-010092-uftc8inx 12566 20 " " '' cord-010092-uftc8inx 12566 21 , , , cord-010092-uftc8inx 12566 22 blood blood NN cord-010092-uftc8inx 12566 23 requirement requirement NN cord-010092-uftc8inx 12566 24 of of IN cord-010092-uftc8inx 12566 25 1401 1401 CD cord-010092-uftc8inx 12566 26 EC EC NNP cord-010092-uftc8inx 12566 27 was be VBD cord-010092-uftc8inx 12566 28 fulfilled fulfil VBN cord-010092-uftc8inx 12566 29 by by IN cord-010092-uftc8inx 12566 30 the the DT cord-010092-uftc8inx 12566 31 initial initial JJ cord-010092-uftc8inx 12566 32 blood blood NN cord-010092-uftc8inx 12566 33 test test NN cord-010092-uftc8inx 12566 34 ( ( -LRB- cord-010092-uftc8inx 12566 35 1102 1102 CD cord-010092-uftc8inx 12566 36 blood blood NN cord-010092-uftc8inx 12566 37 samples sample NNS cord-010092-uftc8inx 12566 38 ) ) -RRB- cord-010092-uftc8inx 12566 39 . . . cord-010092-uftc8inx 12567 1 13.3 13.3 CD cord-010092-uftc8inx 12567 2 % % NN cord-010092-uftc8inx 12567 3 of of IN cord-010092-uftc8inx 12567 4 newborns newborn NNS cord-010092-uftc8inx 12567 5 ( ( -LRB- cord-010092-uftc8inx 12567 6 n n NN cord-010092-uftc8inx 12567 7 = = SYM cord-010092-uftc8inx 12567 8 92 92 CD cord-010092-uftc8inx 12567 9 ) ) -RRB- cord-010092-uftc8inx 12567 10 received receive VBD cord-010092-uftc8inx 12567 11 more more JJR cord-010092-uftc8inx 12567 12 than than IN cord-010092-uftc8inx 12567 13 5 5 CD cord-010092-uftc8inx 12567 14 transfusions transfusion NNS cord-010092-uftc8inx 12567 15 ( ( -LRB- cord-010092-uftc8inx 12567 16 6 6 CD cord-010092-uftc8inx 12567 17 - - SYM cord-010092-uftc8inx 12567 18 21 21 CD cord-010092-uftc8inx 12567 19 ; ; : cord-010092-uftc8inx 12567 20 median median NN cord-010092-uftc8inx 12567 21 = = SYM cord-010092-uftc8inx 12567 22 8) 8) NN cord-010092-uftc8inx 12567 23 accounting account VBG cord-010092-uftc8inx 12567 24 for for IN cord-010092-uftc8inx 12567 25 820 820 CD cord-010092-uftc8inx 12567 26 EC EC NNP cord-010092-uftc8inx 12567 27 released release VBN cord-010092-uftc8inx 12567 28 and and CC cord-010092-uftc8inx 12567 29 for for IN cord-010092-uftc8inx 12567 30 this this DT cord-010092-uftc8inx 12567 31 group group NN cord-010092-uftc8inx 12567 32 381 381 CD cord-010092-uftc8inx 12567 33 blood blood NN cord-010092-uftc8inx 12567 34 samples sample NNS cord-010092-uftc8inx 12567 35 were be VBD cord-010092-uftc8inx 12567 36 required require VBN cord-010092-uftc8inx 12567 37 . . . cord-010092-uftc8inx 12568 1 Summary Summary NNP cord-010092-uftc8inx 12568 2 / / SYM cord-010092-uftc8inx 12568 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 12568 4 : : : cord-010092-uftc8inx 12569 1 With with IN cord-010092-uftc8inx 12569 2 the the DT cord-010092-uftc8inx 12569 3 exception exception NN cord-010092-uftc8inx 12569 4 of of IN cord-010092-uftc8inx 12569 5 babies baby NNS cord-010092-uftc8inx 12569 6 requiring require VBG cord-010092-uftc8inx 12569 7 crossmatch crossmatch NN cord-010092-uftc8inx 12569 8 test test NN cord-010092-uftc8inx 12569 9 , , , cord-010092-uftc8inx 12569 10 381 381 CD cord-010092-uftc8inx 12569 11 blood blood NN cord-010092-uftc8inx 12569 12 tests test NNS cord-010092-uftc8inx 12569 13 were be VBD cord-010092-uftc8inx 12569 14 performed perform VBN cord-010092-uftc8inx 12569 15 to to TO cord-010092-uftc8inx 12569 16 sustain sustain VB cord-010092-uftc8inx 12569 17 643 643 CD cord-010092-uftc8inx 12569 18 infants infant NNS cord-010092-uftc8inx 12569 19 transfused transfuse VBN cord-010092-uftc8inx 12569 20 with with IN cord-010092-uftc8inx 12569 21 2221 2221 CD cord-010092-uftc8inx 12569 22 units unit NNS cord-010092-uftc8inx 12569 23 . . . cord-010092-uftc8inx 12570 1 The the DT cord-010092-uftc8inx 12570 2 alternative alternative JJ cord-010092-uftc8inx 12570 3 option option NN cord-010092-uftc8inx 12570 4 of of IN cord-010092-uftc8inx 12570 5 omitting omit VBG cord-010092-uftc8inx 12570 6 crossmatch crossmatch NN cord-010092-uftc8inx 12570 7 test test NN cord-010092-uftc8inx 12570 8 ( ( -LRB- cord-010092-uftc8inx 12570 9 otherwise otherwise RB cord-010092-uftc8inx 12570 10 suggested suggest VBN cord-010092-uftc8inx 12570 11 by by IN cord-010092-uftc8inx 12570 12 Italian italian JJ cord-010092-uftc8inx 12570 13 Directives Directives NNPS cord-010092-uftc8inx 12570 14 ) ) -RRB- cord-010092-uftc8inx 12570 15 , , , cord-010092-uftc8inx 12570 16 allowed allow VBD cord-010092-uftc8inx 12570 17 a a DT cord-010092-uftc8inx 12570 18 reduction reduction NN cord-010092-uftc8inx 12570 19 of of IN cord-010092-uftc8inx 12570 20 75 75 CD cord-010092-uftc8inx 12570 21 % % NN cord-010092-uftc8inx 12570 22 of of IN cord-010092-uftc8inx 12570 23 blood blood NN cord-010092-uftc8inx 12570 24 drawn draw VBN cord-010092-uftc8inx 12570 25 without without IN cord-010092-uftc8inx 12570 26 any any DT cord-010092-uftc8inx 12570 27 adverse adverse JJ cord-010092-uftc8inx 12570 28 effect effect NN cord-010092-uftc8inx 12570 29 or or CC cord-010092-uftc8inx 12570 30 incident incident NN cord-010092-uftc8inx 12570 31 reported report VBD cord-010092-uftc8inx 12570 32 . . . cord-010092-uftc8inx 12571 1 Due due IN cord-010092-uftc8inx 12571 2 to to IN cord-010092-uftc8inx 12571 3 the the DT cord-010092-uftc8inx 12571 4 relevance relevance NN cord-010092-uftc8inx 12571 5 of of IN cord-010092-uftc8inx 12571 6 anemia anemia NN cord-010092-uftc8inx 12571 7 in in IN cord-010092-uftc8inx 12571 8 premature premature JJ cord-010092-uftc8inx 12571 9 babies baby NNS cord-010092-uftc8inx 12571 10 , , , cord-010092-uftc8inx 12571 11 we -PRON- PRP cord-010092-uftc8inx 12571 12 suggest suggest VBP cord-010092-uftc8inx 12571 13 the the DT cord-010092-uftc8inx 12571 14 application application NN cord-010092-uftc8inx 12571 15 of of IN cord-010092-uftc8inx 12571 16 this this DT cord-010092-uftc8inx 12571 17 transfusion transfusion NN cord-010092-uftc8inx 12571 18 policy policy NN cord-010092-uftc8inx 12571 19 in in IN cord-010092-uftc8inx 12571 20 all all DT cord-010092-uftc8inx 12571 21 newborns newborn NNS cord-010092-uftc8inx 12571 22 in in IN cord-010092-uftc8inx 12571 23 the the DT cord-010092-uftc8inx 12571 24 first first JJ cord-010092-uftc8inx 12571 25 4 4 CD cord-010092-uftc8inx 12571 26 months month NNS cord-010092-uftc8inx 12571 27 of of IN cord-010092-uftc8inx 12571 28 life life NN cord-010092-uftc8inx 12571 29 . . . cord-010092-uftc8inx 12572 1 Background background NN cord-010092-uftc8inx 12572 2 : : : cord-010092-uftc8inx 12573 1 Glucose-6-phosphate glucose-6-phosphate VBP cord-010092-uftc8inx 12573 2 dehydrogenase dehydrogenase NN cord-010092-uftc8inx 12573 3 deficiency deficiency NN cord-010092-uftc8inx 12573 4 ( ( -LRB- cord-010092-uftc8inx 12573 5 G6PDd G6PDd NNP cord-010092-uftc8inx 12573 6 ) ) -RRB- cord-010092-uftc8inx 12573 7 is be VBZ cord-010092-uftc8inx 12573 8 a a DT cord-010092-uftc8inx 12573 9 sexlinked sexlinked NNP cord-010092-uftc8inx 12573 10 enzymopathy enzymopathy NNP cord-010092-uftc8inx 12573 11 which which WDT cord-010092-uftc8inx 12573 12 is be VBZ cord-010092-uftc8inx 12573 13 usually usually RB cord-010092-uftc8inx 12573 14 asymptomatic asymptomatic JJ cord-010092-uftc8inx 12573 15 unless unless IN cord-010092-uftc8inx 12573 16 individuals individual NNS cord-010092-uftc8inx 12573 17 are be VBP cord-010092-uftc8inx 12573 18 exposed expose VBN cord-010092-uftc8inx 12573 19 to to IN cord-010092-uftc8inx 12573 20 oxidative oxidative JJ cord-010092-uftc8inx 12573 21 stress stress NN cord-010092-uftc8inx 12573 22 agents agent NNS cord-010092-uftc8inx 12573 23 . . . cord-010092-uftc8inx 12574 1 The the DT cord-010092-uftc8inx 12574 2 G6PD G6PD NNP cord-010092-uftc8inx 12574 3 202 202 CD cord-010092-uftc8inx 12574 4 genotype genotype NN cord-010092-uftc8inx 12574 5 is be VBZ cord-010092-uftc8inx 12574 6 the the DT cord-010092-uftc8inx 12574 7 most most RBS cord-010092-uftc8inx 12574 8 common common JJ cord-010092-uftc8inx 12574 9 G6PD G6PD NNP cord-010092-uftc8inx 12574 10 genotype genotype NN cord-010092-uftc8inx 12574 11 in in IN cord-010092-uftc8inx 12574 12 sub sub NNP cord-010092-uftc8inx 12574 13 Saharan Saharan NNP cord-010092-uftc8inx 12574 14 Africa Africa NNP cord-010092-uftc8inx 12574 15 ( ( -LRB- cord-010092-uftc8inx 12574 16 sSA ssa NN cord-010092-uftc8inx 12574 17 ) ) -RRB- cord-010092-uftc8inx 12574 18 . . . cord-010092-uftc8inx 12575 1 Some some DT cord-010092-uftc8inx 12575 2 studies study NNS cord-010092-uftc8inx 12575 3 have have VBP cord-010092-uftc8inx 12575 4 linked link VBN cord-010092-uftc8inx 12575 5 blood blood NN cord-010092-uftc8inx 12575 6 from from IN cord-010092-uftc8inx 12575 7 G6PDd G6PDd NNP cord-010092-uftc8inx 12575 8 donors donor NNS cord-010092-uftc8inx 12575 9 to to IN cord-010092-uftc8inx 12575 10 poor poor JJ cord-010092-uftc8inx 12575 11 outcome outcome NN cord-010092-uftc8inx 12575 12 of of IN cord-010092-uftc8inx 12575 13 a a DT cord-010092-uftc8inx 12575 14 transfusion transfusion NN cord-010092-uftc8inx 12575 15 . . . cord-010092-uftc8inx 12576 1 However however RB cord-010092-uftc8inx 12576 2 , , , cord-010092-uftc8inx 12576 3 there there EX cord-010092-uftc8inx 12576 4 are be VBP cord-010092-uftc8inx 12576 5 no no DT cord-010092-uftc8inx 12576 6 genetic genetic JJ cord-010092-uftc8inx 12576 7 screening screening NN cord-010092-uftc8inx 12576 8 programmes programme NNS cord-010092-uftc8inx 12576 9 for for IN cord-010092-uftc8inx 12576 10 blood blood NN cord-010092-uftc8inx 12576 11 donors donor NNS cord-010092-uftc8inx 12576 12 in in IN cord-010092-uftc8inx 12576 13 the the DT cord-010092-uftc8inx 12576 14 region region NN cord-010092-uftc8inx 12576 15 hence hence RB cord-010092-uftc8inx 12576 16 the the DT cord-010092-uftc8inx 12576 17 contribution contribution NN cord-010092-uftc8inx 12576 18 of of IN cord-010092-uftc8inx 12576 19 G6PDd G6PDd NNP cord-010092-uftc8inx 12576 20 to to IN cord-010092-uftc8inx 12576 21 the the DT cord-010092-uftc8inx 12576 22 donor donor NN cord-010092-uftc8inx 12576 23 pool pool NN cord-010092-uftc8inx 12576 24 in in IN cord-010092-uftc8inx 12576 25 the the DT cord-010092-uftc8inx 12576 26 sSA ssa NN cord-010092-uftc8inx 12576 27 setting setting NN cord-010092-uftc8inx 12576 28 had have VBD cord-010092-uftc8inx 12576 29 not not RB cord-010092-uftc8inx 12576 30 been be VBN cord-010092-uftc8inx 12576 31 described describe VBN cord-010092-uftc8inx 12576 32 . . . cord-010092-uftc8inx 12577 1 Aims aim VBZ cord-010092-uftc8inx 12577 2 : : : cord-010092-uftc8inx 12578 1 This this DT cord-010092-uftc8inx 12578 2 study study NN cord-010092-uftc8inx 12578 3 aimed aim VBD cord-010092-uftc8inx 12578 4 to to TO cord-010092-uftc8inx 12578 5 describe describe VB cord-010092-uftc8inx 12578 6 the the DT cord-010092-uftc8inx 12578 7 prevalence prevalence NN cord-010092-uftc8inx 12578 8 of of IN cord-010092-uftc8inx 12578 9 G6PDd G6PDd NNP cord-010092-uftc8inx 12578 10 202 202 CD cord-010092-uftc8inx 12578 11 genotype genotype NN cord-010092-uftc8inx 12578 12 among among IN cord-010092-uftc8inx 12578 13 donors donor NNS cord-010092-uftc8inx 12578 14 in in IN cord-010092-uftc8inx 12578 15 two two CD cord-010092-uftc8inx 12578 16 regions region NNS cord-010092-uftc8inx 12578 17 in in IN cord-010092-uftc8inx 12578 18 Uganda Uganda NNP cord-010092-uftc8inx 12578 19 . . . cord-010092-uftc8inx 12579 1 It -PRON- PRP cord-010092-uftc8inx 12579 2 also also RB cord-010092-uftc8inx 12579 3 described describe VBD cord-010092-uftc8inx 12579 4 the the DT cord-010092-uftc8inx 12579 5 effect effect NN cord-010092-uftc8inx 12579 6 of of IN cord-010092-uftc8inx 12579 7 G6PDd G6PDd NNP cord-010092-uftc8inx 12579 8 and and CC cord-010092-uftc8inx 12579 9 the the DT cord-010092-uftc8inx 12579 10 coinheritance coinheritance NN cord-010092-uftc8inx 12579 11 of of IN cord-010092-uftc8inx 12579 12 haemoglobin haemoglobin NNP cord-010092-uftc8inx 12579 13 S S NNP cord-010092-uftc8inx 12579 14 and and CC cord-010092-uftc8inx 12579 15 a a DT cord-010092-uftc8inx 12579 16 - - HYPH cord-010092-uftc8inx 12579 17 thalassaemia thalassaemia NN cord-010092-uftc8inx 12579 18 on on IN cord-010092-uftc8inx 12579 19 the the DT cord-010092-uftc8inx 12579 20 haematological haematological JJ cord-010092-uftc8inx 12579 21 quality quality NN cord-010092-uftc8inx 12579 22 of of IN cord-010092-uftc8inx 12579 23 blood blood NN cord-010092-uftc8inx 12579 24 . . . cord-010092-uftc8inx 12580 1 Methods method NNS cord-010092-uftc8inx 12580 2 : : : cord-010092-uftc8inx 12580 3 3,255 3,255 CD cord-010092-uftc8inx 12580 4 blood blood NN cord-010092-uftc8inx 12580 5 samples sample NNS cord-010092-uftc8inx 12580 6 from from IN cord-010092-uftc8inx 12580 7 donor donor NN cord-010092-uftc8inx 12580 8 packs pack NNS cord-010092-uftc8inx 12580 9 were be VBD cord-010092-uftc8inx 12580 10 utilized utilize VBN cord-010092-uftc8inx 12580 11 in in IN cord-010092-uftc8inx 12580 12 a a DT cord-010092-uftc8inx 12580 13 transfusion transfusion NN cord-010092-uftc8inx 12580 14 trial trial NN cord-010092-uftc8inx 12580 15 conducted conduct VBN cord-010092-uftc8inx 12580 16 in in IN cord-010092-uftc8inx 12580 17 Uganda Uganda NNP cord-010092-uftc8inx 12580 18 , , , cord-010092-uftc8inx 12580 19 were be VBD cord-010092-uftc8inx 12580 20 genotyped genotype VBN cord-010092-uftc8inx 12580 21 for for IN cord-010092-uftc8inx 12580 22 G6PD G6PD NNP cord-010092-uftc8inx 12580 23 202 202 CD cord-010092-uftc8inx 12580 24 , , , cord-010092-uftc8inx 12580 25 haemoglobin haemoglobin NN cord-010092-uftc8inx 12580 26 S S NNP cord-010092-uftc8inx 12580 27 and and CC cord-010092-uftc8inx 12580 28 a a DT cord-010092-uftc8inx 12580 29 - - HYPH cord-010092-uftc8inx 12580 30 thalassaemia thalassaemia NN cord-010092-uftc8inx 12580 31 . . . cord-010092-uftc8inx 12581 1 Haemoglobin Haemoglobin NNP cord-010092-uftc8inx 12581 2 and and CC cord-010092-uftc8inx 12581 3 haematocrit haematocrit NNP cord-010092-uftc8inx 12581 4 measurements measurement NNS cord-010092-uftc8inx 12581 5 for for IN cord-010092-uftc8inx 12581 6 the the DT cord-010092-uftc8inx 12581 7 donor donor NN cord-010092-uftc8inx 12581 8 units unit NNS cord-010092-uftc8inx 12581 9 ( ( -LRB- cord-010092-uftc8inx 12581 10 packs pack NNS cord-010092-uftc8inx 12581 11 ) ) -RRB- cord-010092-uftc8inx 12581 12 at at IN cord-010092-uftc8inx 12581 13 the the DT cord-010092-uftc8inx 12581 14 time time NN cord-010092-uftc8inx 12581 15 of of IN cord-010092-uftc8inx 12581 16 transfusion transfusion NN cord-010092-uftc8inx 12581 17 were be VBD cord-010092-uftc8inx 12581 18 used use VBN cord-010092-uftc8inx 12581 19 to to TO cord-010092-uftc8inx 12581 20 describe describe VB cord-010092-uftc8inx 12581 21 the the DT cord-010092-uftc8inx 12581 22 effect effect NN cord-010092-uftc8inx 12581 23 of of IN cord-010092-uftc8inx 12581 24 G6PD G6PD NNP cord-010092-uftc8inx 12581 25 202 202 CD cord-010092-uftc8inx 12581 26 and and CC cord-010092-uftc8inx 12581 27 co co NN cord-010092-uftc8inx 12581 28 - - NN cord-010092-uftc8inx 12581 29 inheritance inheritance NN cord-010092-uftc8inx 12581 30 with with IN cord-010092-uftc8inx 12581 31 a a DT cord-010092-uftc8inx 12581 32 - - HYPH cord-010092-uftc8inx 12581 33 thalassaemia thalassaemia NN cord-010092-uftc8inx 12581 34 ( ( -LRB- cord-010092-uftc8inx 12581 35 N n NN cord-010092-uftc8inx 12581 36 = = SYM cord-010092-uftc8inx 12581 37 2,546 2,546 CD cord-010092-uftc8inx 12581 38 ) ) -RRB- cord-010092-uftc8inx 12581 39 and and CC cord-010092-uftc8inx 12581 40 haemoglobin haemoglobin NN cord-010092-uftc8inx 12581 41 S S NNP cord-010092-uftc8inx 12581 42 ( ( -LRB- cord-010092-uftc8inx 12581 43 N n NN cord-010092-uftc8inx 12581 44 = = SYM cord-010092-uftc8inx 12581 45 2,642 2,642 CD cord-010092-uftc8inx 12581 46 ) ) -RRB- cord-010092-uftc8inx 12581 47 on on IN cord-010092-uftc8inx 12581 48 the the DT cord-010092-uftc8inx 12581 49 haematological haematological JJ cord-010092-uftc8inx 12581 50 quality quality NN cord-010092-uftc8inx 12581 51 of of IN cord-010092-uftc8inx 12581 52 blood blood NN cord-010092-uftc8inx 12581 53 packs pack NNS cord-010092-uftc8inx 12581 54 . . . cord-010092-uftc8inx 12582 1 A a DT cord-010092-uftc8inx 12582 2 subset subset NN cord-010092-uftc8inx 12582 3 of of IN cord-010092-uftc8inx 12582 4 142 142 CD cord-010092-uftc8inx 12582 5 donor donor NN cord-010092-uftc8inx 12582 6 blood blood NN cord-010092-uftc8inx 12582 7 packs pack NNS cord-010092-uftc8inx 12582 8 was be VBD cord-010092-uftc8inx 12582 9 utilized utilize VBN cord-010092-uftc8inx 12582 10 to to TO cord-010092-uftc8inx 12582 11 determine determine VB cord-010092-uftc8inx 12582 12 the the DT cord-010092-uftc8inx 12582 13 sensitivity sensitivity NN cord-010092-uftc8inx 12582 14 and and CC cord-010092-uftc8inx 12582 15 specificity specificity NN cord-010092-uftc8inx 12582 16 of of IN cord-010092-uftc8inx 12582 17 the the DT cord-010092-uftc8inx 12582 18 CareStartTM CareStartTM NNP cord-010092-uftc8inx 12582 19 rapid rapid JJ cord-010092-uftc8inx 12582 20 diagnostic diagnostic JJ cord-010092-uftc8inx 12582 21 kit kit NN cord-010092-uftc8inx 12582 22 ( ( -LRB- cord-010092-uftc8inx 12582 23 RDT RDT NNP cord-010092-uftc8inx 12582 24 ) ) -RRB- cord-010092-uftc8inx 12582 25 for for IN cord-010092-uftc8inx 12582 26 G6PDd G6PDd NNP cord-010092-uftc8inx 12582 27 . . . cord-010092-uftc8inx 12583 1 Results result NNS cord-010092-uftc8inx 12583 2 : : : cord-010092-uftc8inx 12584 1 Based base VBN cord-010092-uftc8inx 12584 2 on on IN cord-010092-uftc8inx 12584 3 G6PD G6PD NNP cord-010092-uftc8inx 12584 4 202 202 CD cord-010092-uftc8inx 12584 5 genotyping genotyping NN cord-010092-uftc8inx 12584 6 , , , cord-010092-uftc8inx 12584 7 10.3 10.3 CD cord-010092-uftc8inx 12584 8 % % NN cord-010092-uftc8inx 12584 9 ( ( -LRB- cord-010092-uftc8inx 12584 10 N n NN cord-010092-uftc8inx 12584 11 = = SYM cord-010092-uftc8inx 12584 12 274 274 CD cord-010092-uftc8inx 12584 13 ) ) -RRB- cord-010092-uftc8inx 12584 14 of of IN cord-010092-uftc8inx 12584 15 the the DT cord-010092-uftc8inx 12584 16 blood blood NN cord-010092-uftc8inx 12584 17 samples sample NNS cord-010092-uftc8inx 12584 18 used use VBN cord-010092-uftc8inx 12584 19 in in IN cord-010092-uftc8inx 12584 20 the the DT cord-010092-uftc8inx 12584 21 trial trial NN cord-010092-uftc8inx 12584 22 were be VBD cord-010092-uftc8inx 12584 23 deficient deficient JJ cord-010092-uftc8inx 12584 24 for for IN cord-010092-uftc8inx 12584 25 G6PD G6PD NNP cord-010092-uftc8inx 12584 26 enzyme enzyme NN cord-010092-uftc8inx 12584 27 while while IN cord-010092-uftc8inx 12584 28 5.3 5.3 CD cord-010092-uftc8inx 12584 29 % % NN cord-010092-uftc8inx 12584 30 ( ( -LRB- cord-010092-uftc8inx 12584 31 N n NN cord-010092-uftc8inx 12584 32 = = SYM cord-010092-uftc8inx 12584 33 142 142 CD cord-010092-uftc8inx 12584 34 ) ) -RRB- cord-010092-uftc8inx 12584 35 were be VBD cord-010092-uftc8inx 12584 36 heterozygous heterozygous JJ cord-010092-uftc8inx 12584 37 . . . cord-010092-uftc8inx 12585 1 Significant significant JJ cord-010092-uftc8inx 12585 2 lower low JJR cord-010092-uftc8inx 12585 3 hemoglobin hemoglobin NN cord-010092-uftc8inx 12585 4 values value NNS cord-010092-uftc8inx 12585 5 were be VBD cord-010092-uftc8inx 12585 6 observed observe VBN cord-010092-uftc8inx 12585 7 in in IN cord-010092-uftc8inx 12585 8 red red JJ cord-010092-uftc8inx 12585 9 cell cell NN cord-010092-uftc8inx 12585 10 concentrates concentrate VBZ cord-010092-uftc8inx 12585 11 ( ( -LRB- cord-010092-uftc8inx 12585 12 P p NN cord-010092-uftc8inx 12585 13 = = SYM cord-010092-uftc8inx 12585 14 0.010 0.010 CD cord-010092-uftc8inx 12585 15 ) ) -RRB- cord-010092-uftc8inx 12585 16 and and CC cord-010092-uftc8inx 12585 17 whole whole JJ cord-010092-uftc8inx 12585 18 blood blood NN cord-010092-uftc8inx 12585 19 ( ( -LRB- cord-010092-uftc8inx 12585 20 P p NN cord-010092-uftc8inx 12585 21 = = SYM cord-010092-uftc8inx 12585 22 0.009 0.009 CD cord-010092-uftc8inx 12585 23 ) ) -RRB- cord-010092-uftc8inx 12585 24 donations donation NNS cord-010092-uftc8inx 12585 25 of of IN cord-010092-uftc8inx 12585 26 heterozygous heterozygous JJ cord-010092-uftc8inx 12585 27 G6PD G6PD NNP cord-010092-uftc8inx 12585 28 202 202 CD cord-010092-uftc8inx 12585 29 genotype genotype NN cord-010092-uftc8inx 12585 30 . . . cord-010092-uftc8inx 12586 1 Co co NN cord-010092-uftc8inx 12586 2 - - NN cord-010092-uftc8inx 12586 3 inheritance inheritance NN cord-010092-uftc8inx 12586 4 of of IN cord-010092-uftc8inx 12586 5 G6PDd G6PDd NNP cord-010092-uftc8inx 12586 6 and and CC cord-010092-uftc8inx 12586 7 a a DT cord-010092-uftc8inx 12586 8 - - HYPH cord-010092-uftc8inx 12586 9 thalassaemia thalassaemia NN cord-010092-uftc8inx 12586 10 resulted result VBD cord-010092-uftc8inx 12586 11 in in IN cord-010092-uftc8inx 12586 12 significantly significantly RB cord-010092-uftc8inx 12586 13 lower low JJR cord-010092-uftc8inx 12586 14 haemoglobin haemoglobin NN cord-010092-uftc8inx 12586 15 levels level NNS cord-010092-uftc8inx 12586 16 . . . cord-010092-uftc8inx 12587 1 The the DT cord-010092-uftc8inx 12587 2 CareStartTM CareStartTM NNP cord-010092-uftc8inx 12587 3 RDT RDT NNP cord-010092-uftc8inx 12587 4 test test NN cord-010092-uftc8inx 12587 5 was be VBD cord-010092-uftc8inx 12587 6 83.3 83.3 CD cord-010092-uftc8inx 12587 7 % % NN cord-010092-uftc8inx 12587 8 sensitive sensitive JJ cord-010092-uftc8inx 12587 9 and and CC cord-010092-uftc8inx 12587 10 0.8 0.8 CD cord-010092-uftc8inx 12587 11 % % NN cord-010092-uftc8inx 12587 12 specific specific JJ cord-010092-uftc8inx 12587 13 for for IN cord-010092-uftc8inx 12587 14 detecting detect VBG cord-010092-uftc8inx 12587 15 donor donor NN cord-010092-uftc8inx 12587 16 blood blood NN cord-010092-uftc8inx 12587 17 packs pack NNS cord-010092-uftc8inx 12587 18 with with IN cord-010092-uftc8inx 12587 19 G6PDd G6PDd NNP cord-010092-uftc8inx 12587 20 . . . cord-010092-uftc8inx 12588 1 Summary Summary NNP cord-010092-uftc8inx 12588 2 / / SYM cord-010092-uftc8inx 12588 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 12588 4 : : : cord-010092-uftc8inx 12589 1 The the DT cord-010092-uftc8inx 12589 2 prevalence prevalence NN cord-010092-uftc8inx 12589 3 of of IN cord-010092-uftc8inx 12589 4 G6PDd G6PDd NNP cord-010092-uftc8inx 12589 5 among among IN cord-010092-uftc8inx 12589 6 Ugandan ugandan JJ cord-010092-uftc8inx 12589 7 blood blood NN cord-010092-uftc8inx 12589 8 donors donor NNS cord-010092-uftc8inx 12589 9 was be VBD cord-010092-uftc8inx 12589 10 similar similar JJ cord-010092-uftc8inx 12589 11 to to IN cord-010092-uftc8inx 12589 12 that that DT cord-010092-uftc8inx 12589 13 in in IN cord-010092-uftc8inx 12589 14 the the DT cord-010092-uftc8inx 12589 15 general general JJ cord-010092-uftc8inx 12589 16 population population NN cord-010092-uftc8inx 12589 17 . . . cord-010092-uftc8inx 12590 1 The the DT cord-010092-uftc8inx 12590 2 heterozygous heterozygous JJ cord-010092-uftc8inx 12590 3 genotype genotype NN cord-010092-uftc8inx 12590 4 resulted result VBD cord-010092-uftc8inx 12590 5 in in IN cord-010092-uftc8inx 12590 6 lower low JJR cord-010092-uftc8inx 12590 7 haemoglobin haemoglobin NN cord-010092-uftc8inx 12590 8 concentration concentration NN cord-010092-uftc8inx 12590 9 of of IN cord-010092-uftc8inx 12590 10 the the DT cord-010092-uftc8inx 12590 11 blood blood NN cord-010092-uftc8inx 12590 12 units unit NNS cord-010092-uftc8inx 12590 13 . . . cord-010092-uftc8inx 12591 1 The the DT cord-010092-uftc8inx 12591 2 use use NN cord-010092-uftc8inx 12591 3 of of IN cord-010092-uftc8inx 12591 4 CareStartTM CareStartTM NNP cord-010092-uftc8inx 12591 5 RDT RDT NNP cord-010092-uftc8inx 12591 6 for for IN cord-010092-uftc8inx 12591 7 screening screening NN cord-010092-uftc8inx 12591 8 of of IN cord-010092-uftc8inx 12591 9 stored store VBN cord-010092-uftc8inx 12591 10 blood blood NN cord-010092-uftc8inx 12591 11 units unit NNS cord-010092-uftc8inx 12591 12 was be VBD cord-010092-uftc8inx 12591 13 not not RB cord-010092-uftc8inx 12591 14 as as RB cord-010092-uftc8inx 12591 15 efficient efficient JJ cord-010092-uftc8inx 12591 16 in in IN cord-010092-uftc8inx 12591 17 this this DT cord-010092-uftc8inx 12591 18 study study NN cord-010092-uftc8inx 12591 19 hence hence RB cord-010092-uftc8inx 12591 20 further far RBR cord-010092-uftc8inx 12591 21 testing testing NN cord-010092-uftc8inx 12591 22 for for IN cord-010092-uftc8inx 12591 23 the the DT cord-010092-uftc8inx 12591 24 determination determination NN cord-010092-uftc8inx 12591 25 of of IN cord-010092-uftc8inx 12591 26 G6PDd G6PDd NNP cord-010092-uftc8inx 12591 27 needs need VBZ cord-010092-uftc8inx 12591 28 to to TO cord-010092-uftc8inx 12591 29 be be VB cord-010092-uftc8inx 12591 30 done do VBN cord-010092-uftc8inx 12591 31 on on IN cord-010092-uftc8inx 12591 32 fresh fresh JJ cord-010092-uftc8inx 12591 33 samples sample NNS cord-010092-uftc8inx 12591 34 from from IN cord-010092-uftc8inx 12591 35 donors donor NNS cord-010092-uftc8inx 12591 36 . . . cord-010092-uftc8inx 12591 37 _SP cord-010092-uftc8inx 12592 1 Transfusion transfusion NN cord-010092-uftc8inx 12592 2 medicine medicine NN cord-010092-uftc8inx 12592 3 , , , cord-010092-uftc8inx 12592 4 Jaypee Jaypee NNP cord-010092-uftc8inx 12592 5 Hospital Hospital NNP cord-010092-uftc8inx 12592 6 , , , cord-010092-uftc8inx 12592 7 Noida Noida NNP cord-010092-uftc8inx 12592 8 , , , cord-010092-uftc8inx 12593 1 India India NNP cord-010092-uftc8inx 12593 2 Background Background NNP cord-010092-uftc8inx 12593 3 : : : cord-010092-uftc8inx 12593 4 during during IN cord-010092-uftc8inx 12593 5 last last JJ cord-010092-uftc8inx 12593 6 two two CD cord-010092-uftc8inx 12593 7 decade decade NN cord-010092-uftc8inx 12593 8 there there EX cord-010092-uftc8inx 12593 9 has have VBZ cord-010092-uftc8inx 12593 10 been be VBN cord-010092-uftc8inx 12593 11 a a DT cord-010092-uftc8inx 12593 12 continuous continuous JJ cord-010092-uftc8inx 12593 13 remarkable remarkable JJ cord-010092-uftc8inx 12593 14 improvement improvement NN cord-010092-uftc8inx 12593 15 in in IN cord-010092-uftc8inx 12593 16 desensitization desensitization NN cord-010092-uftc8inx 12593 17 therapy therapy NN cord-010092-uftc8inx 12593 18 in in IN cord-010092-uftc8inx 12593 19 high high JJ cord-010092-uftc8inx 12593 20 risk risk NN cord-010092-uftc8inx 12593 21 HLA HLA NNP cord-010092-uftc8inx 12593 22 sensitized sensitize VBN cord-010092-uftc8inx 12593 23 kidney kidney NN cord-010092-uftc8inx 12593 24 recipients recipient NNS cord-010092-uftc8inx 12593 25 . . . cord-010092-uftc8inx 12594 1 In in IN cord-010092-uftc8inx 12594 2 India India NNP cord-010092-uftc8inx 12594 3 there there EX cord-010092-uftc8inx 12594 4 has have VBZ cord-010092-uftc8inx 12594 5 been be VBN cord-010092-uftc8inx 12594 6 a a DT cord-010092-uftc8inx 12594 7 tremendous tremendous JJ cord-010092-uftc8inx 12594 8 increase increase NN cord-010092-uftc8inx 12594 9 in in IN cord-010092-uftc8inx 12594 10 the the DT cord-010092-uftc8inx 12594 11 number number NN cord-010092-uftc8inx 12594 12 of of IN cord-010092-uftc8inx 12594 13 kidney kidney NN cord-010092-uftc8inx 12594 14 transplantations transplantation NNS cord-010092-uftc8inx 12594 15 in in IN cord-010092-uftc8inx 12594 16 patients patient NNS cord-010092-uftc8inx 12594 17 having have VBG cord-010092-uftc8inx 12594 18 anti anti JJ cord-010092-uftc8inx 12594 19 - - JJ cord-010092-uftc8inx 12594 20 HLA HLA NNP cord-010092-uftc8inx 12594 21 antibodies antibody NNS cord-010092-uftc8inx 12594 22 ( ( -LRB- cord-010092-uftc8inx 12594 23 HLA HLA NNP cord-010092-uftc8inx 12594 24 sensitized sensitize VBN cord-010092-uftc8inx 12594 25 ) ) -RRB- cord-010092-uftc8inx 12594 26 with with IN cord-010092-uftc8inx 12594 27 excellent excellent JJ cord-010092-uftc8inx 12594 28 success success NN cord-010092-uftc8inx 12594 29 rate rate NN cord-010092-uftc8inx 12594 30 . . . cord-010092-uftc8inx 12595 1 Aims aim VBZ cord-010092-uftc8inx 12595 2 : : : cord-010092-uftc8inx 12596 1 In in IN cord-010092-uftc8inx 12596 2 present present JJ cord-010092-uftc8inx 12596 3 study study NN cord-010092-uftc8inx 12596 4 , , , cord-010092-uftc8inx 12596 5 we -PRON- PRP cord-010092-uftc8inx 12596 6 are be VBP cord-010092-uftc8inx 12596 7 describing describe VBG cord-010092-uftc8inx 12596 8 successful successful JJ cord-010092-uftc8inx 12596 9 role role NN cord-010092-uftc8inx 12596 10 of of IN cord-010092-uftc8inx 12596 11 desensitization desensitization NN cord-010092-uftc8inx 12596 12 in in IN cord-010092-uftc8inx 12596 13 39 39 CD cord-010092-uftc8inx 12596 14 HLA HLA NNP cord-010092-uftc8inx 12596 15 sensitized sensitize VBN cord-010092-uftc8inx 12596 16 patients patient NNS cord-010092-uftc8inx 12596 17 having have VBG cord-010092-uftc8inx 12596 18 preformed preformed JJ cord-010092-uftc8inx 12596 19 donor donor NN cord-010092-uftc8inx 12596 20 - - HYPH cord-010092-uftc8inx 12596 21 specific specific JJ cord-010092-uftc8inx 12596 22 HLA HLA NNP cord-010092-uftc8inx 12596 23 antibody antibody NN cord-010092-uftc8inx 12596 24 ( ( -LRB- cord-010092-uftc8inx 12596 25 DSA DSA NNP cord-010092-uftc8inx 12596 26 ) ) -RRB- cord-010092-uftc8inx 12596 27 . . . cord-010092-uftc8inx 12597 1 Methods method NNS cord-010092-uftc8inx 12597 2 : : : cord-010092-uftc8inx 12598 1 All all DT cord-010092-uftc8inx 12598 2 patients patient NNS cord-010092-uftc8inx 12598 3 were be VBD cord-010092-uftc8inx 12598 4 preconditioned precondition VBN cord-010092-uftc8inx 12598 5 with with IN cord-010092-uftc8inx 12598 6 combined combined JJ cord-010092-uftc8inx 12598 7 modality modality NN cord-010092-uftc8inx 12598 8 of of IN cord-010092-uftc8inx 12598 9 a a DT cord-010092-uftc8inx 12598 10 standard standard JJ cord-010092-uftc8inx 12598 11 dose dose NN cord-010092-uftc8inx 12598 12 of of IN cord-010092-uftc8inx 12598 13 rituximab rituximab NN cord-010092-uftc8inx 12598 14 , , , cord-010092-uftc8inx 12598 15 therapeutic therapeutic JJ cord-010092-uftc8inx 12598 16 plasma plasma NN cord-010092-uftc8inx 12598 17 exchange exchange NN cord-010092-uftc8inx 12598 18 ( ( -LRB- cord-010092-uftc8inx 12598 19 TPE TPE NNP cord-010092-uftc8inx 12598 20 ) ) -RRB- cord-010092-uftc8inx 12598 21 and and CC cord-010092-uftc8inx 12598 22 low low JJ cord-010092-uftc8inx 12598 23 dose dose NN cord-010092-uftc8inx 12598 24 IVIG IVIG NNP cord-010092-uftc8inx 12598 25 . . . cord-010092-uftc8inx 12599 1 TPE TPE NNP cord-010092-uftc8inx 12599 2 was be VBD cord-010092-uftc8inx 12599 3 started start VBN cord-010092-uftc8inx 12599 4 using use VBG cord-010092-uftc8inx 12599 5 COM com NN cord-010092-uftc8inx 12599 6 . . . cord-010092-uftc8inx 12600 1 TEC TEC NNP cord-010092-uftc8inx 12600 2 ( ( -LRB- cord-010092-uftc8inx 12600 3 Fresenius Fresenius NNP cord-010092-uftc8inx 12600 4 Kabi Kabi NNP cord-010092-uftc8inx 12600 5 , , , cord-010092-uftc8inx 12600 6 Germany Germany NNP cord-010092-uftc8inx 12600 7 ) ) -RRB- cord-010092-uftc8inx 12600 8 after after IN cord-010092-uftc8inx 12600 9 21 21 CD cord-010092-uftc8inx 12600 10 days day NNS cord-010092-uftc8inx 12600 11 of of IN cord-010092-uftc8inx 12600 12 administration administration NN cord-010092-uftc8inx 12600 13 of of IN cord-010092-uftc8inx 12600 14 Rituximab Rituximab NNP cord-010092-uftc8inx 12600 15 . . . cord-010092-uftc8inx 12601 1 Complement complement VB cord-010092-uftc8inx 12601 2 dependent dependent JJ cord-010092-uftc8inx 12601 3 cytotoxicity cytotoxicity NN cord-010092-uftc8inx 12601 4 cross cross NN cord-010092-uftc8inx 12601 5 match match NN cord-010092-uftc8inx 12601 6 ( ( -LRB- cord-010092-uftc8inx 12601 7 CDC CDC NNP cord-010092-uftc8inx 12601 8 - - HYPH cord-010092-uftc8inx 12601 9 XM XM NNP cord-010092-uftc8inx 12601 10 ) ) -RRB- cord-010092-uftc8inx 12601 11 , , , cord-010092-uftc8inx 12601 12 Luminex Luminex NNP cord-010092-uftc8inx 12601 13 cross cross NN cord-010092-uftc8inx 12601 14 match match NN cord-010092-uftc8inx 12601 15 with with IN cord-010092-uftc8inx 12601 16 donor donor NN cord-010092-uftc8inx 12601 17 lysates lysate NNS cord-010092-uftc8inx 12601 18 ( ( -LRB- cord-010092-uftc8inx 12601 19 LM LM NNP cord-010092-uftc8inx 12601 20 - - HYPH cord-010092-uftc8inx 12601 21 XM XM NNP cord-010092-uftc8inx 12601 22 , , , cord-010092-uftc8inx 12601 23 Immucor Immucor NNP cord-010092-uftc8inx 12601 24 INC INC NNP cord-010092-uftc8inx 12601 25 . . NNP cord-010092-uftc8inx 12601 26 , , , cord-010092-uftc8inx 12601 27 GA GA NNP cord-010092-uftc8inx 12601 28 , , , cord-010092-uftc8inx 12601 29 USA USA NNP cord-010092-uftc8inx 12601 30 ) ) -RRB- cord-010092-uftc8inx 12601 31 and and CC cord-010092-uftc8inx 12601 32 flow flow VB cord-010092-uftc8inx 12601 33 cytometry cytometry NN cord-010092-uftc8inx 12601 34 cross cross NN cord-010092-uftc8inx 12601 35 match match NN cord-010092-uftc8inx 12601 36 ( ( -LRB- cord-010092-uftc8inx 12601 37 FC FC NNP cord-010092-uftc8inx 12601 38 - - HYPH cord-010092-uftc8inx 12601 39 XM XM NNP cord-010092-uftc8inx 12601 40 , , , cord-010092-uftc8inx 12601 41 BD BD NNP cord-010092-uftc8inx 12601 42 FACS FACS NNP cord-010092-uftc8inx 12601 43 Canto Canto NNP cord-010092-uftc8inx 12601 44 II II NNP cord-010092-uftc8inx 12601 45 ) ) -RRB- cord-010092-uftc8inx 12601 46 . . . cord-010092-uftc8inx 12601 47 ) ) -RRB- cord-010092-uftc8inx 12601 48 was be VBD cord-010092-uftc8inx 12601 49 done do VBN cord-010092-uftc8inx 12601 50 in in IN cord-010092-uftc8inx 12601 51 all all DT cord-010092-uftc8inx 12601 52 cases case NNS cord-010092-uftc8inx 12601 53 . . . cord-010092-uftc8inx 12602 1 If if IN cord-010092-uftc8inx 12602 2 any any DT cord-010092-uftc8inx 12602 3 of of IN cord-010092-uftc8inx 12602 4 the the DT cord-010092-uftc8inx 12602 5 three three CD cord-010092-uftc8inx 12602 6 tests test NNS cord-010092-uftc8inx 12602 7 was be VBD cord-010092-uftc8inx 12602 8 positive positive JJ cord-010092-uftc8inx 12602 9 , , , cord-010092-uftc8inx 12602 10 single single JJ cord-010092-uftc8inx 12602 11 antigen antigen NN cord-010092-uftc8inx 12602 12 bead bead NN cord-010092-uftc8inx 12602 13 assay assay NN cord-010092-uftc8inx 12602 14 ( ( -LRB- cord-010092-uftc8inx 12602 15 SAB SAB NNP cord-010092-uftc8inx 12602 16 ) ) -RRB- cord-010092-uftc8inx 12602 17 was be VBD cord-010092-uftc8inx 12602 18 performed perform VBN cord-010092-uftc8inx 12602 19 . . . cord-010092-uftc8inx 12603 1 Desensitization desensitization NN cord-010092-uftc8inx 12603 2 therapy therapy NN cord-010092-uftc8inx 12603 3 was be VBD cord-010092-uftc8inx 12603 4 given give VBN cord-010092-uftc8inx 12603 5 in in IN cord-010092-uftc8inx 12603 6 all all DT cord-010092-uftc8inx 12603 7 cases case NNS cord-010092-uftc8inx 12603 8 where where WRB cord-010092-uftc8inx 12603 9 DSA DSA NNP cord-010092-uftc8inx 12603 10 was be VBD cord-010092-uftc8inx 12603 11 detected detect VBN cord-010092-uftc8inx 12603 12 . . . cord-010092-uftc8inx 12604 1 Pretransplant Pretransplant NNP cord-010092-uftc8inx 12604 2 TPE tpe NN cord-010092-uftc8inx 12604 3 procedures procedure NNS cord-010092-uftc8inx 12604 4 were be VBD cord-010092-uftc8inx 12604 5 done do VBN cord-010092-uftc8inx 12604 6 until until IN cord-010092-uftc8inx 12604 7 DSA DSA NNP cord-010092-uftc8inx 12604 8 ( ( -LRB- cord-010092-uftc8inx 12604 9 MFI MFI NNP cord-010092-uftc8inx 12604 10 < < XX cord-010092-uftc8inx 12604 11 1000 1000 CD cord-010092-uftc8inx 12604 12 ) ) -RRB- cord-010092-uftc8inx 12604 13 and and CC cord-010092-uftc8inx 12604 14 CDC CDC NNP cord-010092-uftc8inx 12604 15 - - HYPH cord-010092-uftc8inx 12604 16 XM XM NNP cord-010092-uftc8inx 12604 17 became become VBD cord-010092-uftc8inx 12604 18 negative negative JJ cord-010092-uftc8inx 12604 19 . . . cord-010092-uftc8inx 12605 1 CDCXM CDCXM NNP cord-010092-uftc8inx 12605 2 labeled label VBD cord-010092-uftc8inx 12605 3 positive positive JJ cord-010092-uftc8inx 12605 4 at at IN cord-010092-uftc8inx 12605 5 ≥ ≥ CD cord-010092-uftc8inx 12605 6 10 10 CD cord-010092-uftc8inx 12605 7 % % NN cord-010092-uftc8inx 12605 8 . . . cord-010092-uftc8inx 12606 1 T t NN cord-010092-uftc8inx 12606 2 - - HYPH cord-010092-uftc8inx 12606 3 cell cell NN cord-010092-uftc8inx 12606 4 FCMX FCMX NNP cord-010092-uftc8inx 12606 5 was be VBD cord-010092-uftc8inx 12606 6 considered consider VBN cord-010092-uftc8inx 12606 7 positive positive JJ cord-010092-uftc8inx 12606 8 above above IN cord-010092-uftc8inx 12606 9 42 42 CD cord-010092-uftc8inx 12606 10 MFI MFI NNP cord-010092-uftc8inx 12606 11 and and CC cord-010092-uftc8inx 12606 12 B b NN cord-010092-uftc8inx 12606 13 - - HYPH cord-010092-uftc8inx 12606 14 cell cell NN cord-010092-uftc8inx 12606 15 FCMX FCMX NNP cord-010092-uftc8inx 12606 16 was be VBD cord-010092-uftc8inx 12606 17 considered consider VBN cord-010092-uftc8inx 12606 18 positive positive JJ cord-010092-uftc8inx 12606 19 above above IN cord-010092-uftc8inx 12606 20 120 120 CD cord-010092-uftc8inx 12606 21 MFI MFI NNS cord-010092-uftc8inx 12606 22 . . . cord-010092-uftc8inx 12607 1 LMXM LMXM NNP cord-010092-uftc8inx 12607 2 was be VBD cord-010092-uftc8inx 12607 3 considered consider VBN cord-010092-uftc8inx 12607 4 positive positive JJ cord-010092-uftc8inx 12607 5 above above IN cord-010092-uftc8inx 12607 6 500 500 CD cord-010092-uftc8inx 12607 7 MFI MFI NNP cord-010092-uftc8inx 12607 8 . . . cord-010092-uftc8inx 12608 1 SAB SAB NNP cord-010092-uftc8inx 12608 2 was be VBD cord-010092-uftc8inx 12608 3 performed perform VBN cord-010092-uftc8inx 12608 4 using use VBG cord-010092-uftc8inx 12608 5 Lifecodes Lifecodes NNP cord-010092-uftc8inx 12608 6 single single JJ cord-010092-uftc8inx 12608 7 antigen antigen NN cord-010092-uftc8inx 12608 8 ( ( -LRB- cord-010092-uftc8inx 12608 9 LSA LSA NNP cord-010092-uftc8inx 12608 10 ) ) -RRB- cord-010092-uftc8inx 12608 11 class class NN cord-010092-uftc8inx 12608 12 I i NN cord-010092-uftc8inx 12608 13 and and CC cord-010092-uftc8inx 12608 14 class class NN cord-010092-uftc8inx 12608 15 II ii NN cord-010092-uftc8inx 12608 16 kits kit NNS cord-010092-uftc8inx 12608 17 ( ( -LRB- cord-010092-uftc8inx 12608 18 Immucor Immucor NNP cord-010092-uftc8inx 12608 19 , , , cord-010092-uftc8inx 12608 20 USA USA NNP cord-010092-uftc8inx 12608 21 ) ) -RRB- cord-010092-uftc8inx 12608 22 . . . cord-010092-uftc8inx 12609 1 If if IN cord-010092-uftc8inx 12609 2 the the DT cord-010092-uftc8inx 12609 3 specificity specificity NN cord-010092-uftc8inx 12609 4 of of IN cord-010092-uftc8inx 12609 5 anti anti JJ cord-010092-uftc8inx 12609 6 - - JJ cord-010092-uftc8inx 12609 7 HLA HLA NNP cord-010092-uftc8inx 12609 8 antibodies antibody NNS cord-010092-uftc8inx 12609 9 was be VBD cord-010092-uftc8inx 12609 10 against against IN cord-010092-uftc8inx 12609 11 donor donor NN cord-010092-uftc8inx 12609 12 HLA HLA NNP cord-010092-uftc8inx 12609 13 antigen(s antigen(s NNP cord-010092-uftc8inx 12609 14 ) ) -RRB- cord-010092-uftc8inx 12610 1 it -PRON- PRP cord-010092-uftc8inx 12610 2 was be VBD cord-010092-uftc8inx 12610 3 called call VBN cord-010092-uftc8inx 12610 4 as as IN cord-010092-uftc8inx 12610 5 donor donor NN cord-010092-uftc8inx 12610 6 specific specific JJ cord-010092-uftc8inx 12610 7 antibody antibody NN cord-010092-uftc8inx 12610 8 ( ( -LRB- cord-010092-uftc8inx 12610 9 DSA DSA NNP cord-010092-uftc8inx 12610 10 ) ) -RRB- cord-010092-uftc8inx 12610 11 . . . cord-010092-uftc8inx 12611 1 Results result NNS cord-010092-uftc8inx 12611 2 : : : cord-010092-uftc8inx 12612 1 Present present JJ cord-010092-uftc8inx 12612 2 study study NN cord-010092-uftc8inx 12612 3 demonstrated demonstrate VBD cord-010092-uftc8inx 12612 4 the the DT cord-010092-uftc8inx 12612 5 diagnostic diagnostic JJ cord-010092-uftc8inx 12612 6 and and CC cord-010092-uftc8inx 12612 7 clinical clinical JJ cord-010092-uftc8inx 12612 8 superiority superiority NN cord-010092-uftc8inx 12612 9 of of IN cord-010092-uftc8inx 12612 10 adding add VBG cord-010092-uftc8inx 12612 11 FC FC NNP cord-010092-uftc8inx 12612 12 - - HYPH cord-010092-uftc8inx 12612 13 XM XM NNP cord-010092-uftc8inx 12612 14 and and CC cord-010092-uftc8inx 12612 15 LM LM NNP cord-010092-uftc8inx 12612 16 - - HYPH cord-010092-uftc8inx 12612 17 XM XM NNP cord-010092-uftc8inx 12612 18 in in IN cord-010092-uftc8inx 12612 19 pretransplant pretransplant JJ cord-010092-uftc8inx 12612 20 compatibility compatibility NN cord-010092-uftc8inx 12612 21 testing testing NN cord-010092-uftc8inx 12612 22 algorithm algorithm NN cord-010092-uftc8inx 12612 23 over over IN cord-010092-uftc8inx 12612 24 CDC CDC NNP cord-010092-uftc8inx 12612 25 - - HYPH cord-010092-uftc8inx 12612 26 XM XM NNP cord-010092-uftc8inx 12612 27 . . . cord-010092-uftc8inx 12613 1 CDC CDC NNP cord-010092-uftc8inx 12613 2 - - HYPH cord-010092-uftc8inx 12613 3 XM XM NNP cord-010092-uftc8inx 12613 4 alone alone RB cord-010092-uftc8inx 12613 5 was be VBD cord-010092-uftc8inx 12613 6 not not RB cord-010092-uftc8inx 12613 7 able able JJ cord-010092-uftc8inx 12613 8 to to TO cord-010092-uftc8inx 12613 9 detect detect VB cord-010092-uftc8inx 12613 10 anti anti JJ cord-010092-uftc8inx 12613 11 - - JJ cord-010092-uftc8inx 12613 12 HLA HLA NNP cord-010092-uftc8inx 12613 13 antibody antibody NN cord-010092-uftc8inx 12613 14 in in IN cord-010092-uftc8inx 12613 15 8 8 CD cord-010092-uftc8inx 12613 16 patients patient NNS cord-010092-uftc8inx 12613 17 ( ( -LRB- cord-010092-uftc8inx 12613 18 20.5 20.5 CD cord-010092-uftc8inx 12613 19 % % NN cord-010092-uftc8inx 12613 20 ) ) -RRB- cord-010092-uftc8inx 12613 21 . . . cord-010092-uftc8inx 12614 1 Among among IN cord-010092-uftc8inx 12614 2 the the DT cord-010092-uftc8inx 12614 3 three three CD cord-010092-uftc8inx 12614 4 pretransplant pretransplant JJ cord-010092-uftc8inx 12614 5 compatibility compatibility NN cord-010092-uftc8inx 12614 6 tests test NNS cord-010092-uftc8inx 12614 7 , , , cord-010092-uftc8inx 12614 8 FCXM FCXM NNP cord-010092-uftc8inx 12614 9 demonstrated demonstrate VBD cord-010092-uftc8inx 12614 10 highest high JJS cord-010092-uftc8inx 12614 11 sensitivity sensitivity NN cord-010092-uftc8inx 12614 12 . . . cord-010092-uftc8inx 12615 1 Among among IN cord-010092-uftc8inx 12615 2 the the DT cord-010092-uftc8inx 12615 3 39 39 CD cord-010092-uftc8inx 12615 4 cases case NNS cord-010092-uftc8inx 12615 5 initially initially RB cord-010092-uftc8inx 12615 6 screened screen VBD cord-010092-uftc8inx 12615 7 35 35 CD cord-010092-uftc8inx 12615 8 showed show VBD cord-010092-uftc8inx 12615 9 DSA DSA NNP cord-010092-uftc8inx 12615 10 positivity positivity NN cord-010092-uftc8inx 12615 11 in in IN cord-010092-uftc8inx 12615 12 SAB SAB NNP cord-010092-uftc8inx 12615 13 . . . cord-010092-uftc8inx 12616 1 Desensitization desensitization NN cord-010092-uftc8inx 12616 2 was be VBD cord-010092-uftc8inx 12616 3 done do VBN cord-010092-uftc8inx 12616 4 in in IN cord-010092-uftc8inx 12616 5 those those DT cord-010092-uftc8inx 12616 6 35 35 CD cord-010092-uftc8inx 12616 7 cases case NNS cord-010092-uftc8inx 12616 8 only only RB cord-010092-uftc8inx 12616 9 . . . cord-010092-uftc8inx 12617 1 In in IN cord-010092-uftc8inx 12617 2 our -PRON- PRP$ cord-010092-uftc8inx 12617 3 study study NN cord-010092-uftc8inx 12617 4 , , , cord-010092-uftc8inx 12617 5 SAB SAB NNP cord-010092-uftc8inx 12617 6 was be VBD cord-010092-uftc8inx 12617 7 positive positive JJ cord-010092-uftc8inx 12617 8 for for IN cord-010092-uftc8inx 12617 9 class class NN cord-010092-uftc8inx 12617 10 II II NNP cord-010092-uftc8inx 12617 11 alone alone JJ cord-010092-uftc8inx 12617 12 in in IN cord-010092-uftc8inx 12617 13 13(37 13(37 CD cord-010092-uftc8inx 12617 14 % % NN cord-010092-uftc8inx 12617 15 ) ) -RRB- cord-010092-uftc8inx 12617 16 while while IN cord-010092-uftc8inx 12617 17 in in IN cord-010092-uftc8inx 12617 18 remaining remain VBG cord-010092-uftc8inx 12617 19 22 22 CD cord-010092-uftc8inx 12617 20 ( ( -LRB- cord-010092-uftc8inx 12617 21 63 63 CD cord-010092-uftc8inx 12617 22 % % NN cord-010092-uftc8inx 12617 23 ) ) -RRB- cord-010092-uftc8inx 12617 24 cases case NNS cord-010092-uftc8inx 12617 25 it -PRON- PRP cord-010092-uftc8inx 12617 26 was be VBD cord-010092-uftc8inx 12617 27 positive positive JJ cord-010092-uftc8inx 12617 28 for for IN cord-010092-uftc8inx 12617 29 both both DT cord-010092-uftc8inx 12617 30 class class NN cord-010092-uftc8inx 12617 31 1 1 CD cord-010092-uftc8inx 12617 32 and and CC cord-010092-uftc8inx 12617 33 class class NN cord-010092-uftc8inx 12617 34 II ii NN cord-010092-uftc8inx 12617 35 . . . cord-010092-uftc8inx 12618 1 The the DT cord-010092-uftc8inx 12618 2 number number NN cord-010092-uftc8inx 12618 3 of of IN cord-010092-uftc8inx 12618 4 pre pre JJ cord-010092-uftc8inx 12618 5 transplant transplant NN cord-010092-uftc8inx 12618 6 TPE tpe NN cord-010092-uftc8inx 12618 7 procedures procedure NNS cord-010092-uftc8inx 12618 8 required require VBN cord-010092-uftc8inx 12618 9 was be VBD cord-010092-uftc8inx 12618 10 6.7 6.7 CD cord-010092-uftc8inx 12618 11 ( ( -LRB- cord-010092-uftc8inx 12618 12 1 1 CD cord-010092-uftc8inx 12618 13 ) ) -RRB- cord-010092-uftc8inx 12618 14 ( ( -LRB- cord-010092-uftc8inx 12618 15 2 2 LS cord-010092-uftc8inx 12618 16 ) ) -RRB- cord-010092-uftc8inx 12618 17 ( ( -LRB- cord-010092-uftc8inx 12618 18 3 3 LS cord-010092-uftc8inx 12618 19 ) ) -RRB- cord-010092-uftc8inx 12618 20 ( ( -LRB- cord-010092-uftc8inx 12618 21 4 4 LS cord-010092-uftc8inx 12618 22 ) ) -RRB- cord-010092-uftc8inx 12618 23 ( ( -LRB- cord-010092-uftc8inx 12618 24 5 5 LS cord-010092-uftc8inx 12618 25 ) ) -RRB- cord-010092-uftc8inx 12618 26 ( ( -LRB- cord-010092-uftc8inx 12618 27 6 6 LS cord-010092-uftc8inx 12618 28 ) ) -RRB- cord-010092-uftc8inx 12618 29 ( ( -LRB- cord-010092-uftc8inx 12618 30 7 7 LS cord-010092-uftc8inx 12618 31 ) ) -RRB- cord-010092-uftc8inx 12618 32 ( ( -LRB- cord-010092-uftc8inx 12618 33 8) 8) NNP cord-010092-uftc8inx 12618 34 ( ( -LRB- cord-010092-uftc8inx 12618 35 9 9 CD cord-010092-uftc8inx 12618 36 ) ) -RRB- cord-010092-uftc8inx 12618 37 ( ( -LRB- cord-010092-uftc8inx 12618 38 10 10 CD cord-010092-uftc8inx 12618 39 ) ) -RRB- cord-010092-uftc8inx 12618 40 ( ( -LRB- cord-010092-uftc8inx 12618 41 11 11 CD cord-010092-uftc8inx 12618 42 ) ) -RRB- cord-010092-uftc8inx 12618 43 . . . cord-010092-uftc8inx 12619 1 The the DT cord-010092-uftc8inx 12619 2 mean mean JJ cord-010092-uftc8inx 12619 3 number number NN cord-010092-uftc8inx 12619 4 of of IN cord-010092-uftc8inx 12619 5 post post JJ cord-010092-uftc8inx 12619 6 - - JJ cord-010092-uftc8inx 12619 7 transplant transplant NN cord-010092-uftc8inx 12619 8 TPE tpe NN cord-010092-uftc8inx 12619 9 sessions session NNS cord-010092-uftc8inx 12619 10 required require VBN cord-010092-uftc8inx 12619 11 was be VBD cord-010092-uftc8inx 12619 12 0.7 0.7 CD cord-010092-uftc8inx 12620 1 ( ( -LRB- cord-010092-uftc8inx 12620 2 Range Range NNP cord-010092-uftc8inx 12620 3 , , , cord-010092-uftc8inx 12620 4 1 1 CD cord-010092-uftc8inx 12620 5 - - SYM cord-010092-uftc8inx 12620 6 6 6 CD cord-010092-uftc8inx 12620 7 ) ) -RRB- cord-010092-uftc8inx 12620 8 . . . cord-010092-uftc8inx 12621 1 During during IN cord-010092-uftc8inx 12621 2 pretransplant pretransplant NN cord-010092-uftc8inx 12621 3 and and CC cord-010092-uftc8inx 12621 4 post post JJ cord-010092-uftc8inx 12621 5 transplant transplant NN cord-010092-uftc8inx 12621 6 TPE tpe NN cord-010092-uftc8inx 12621 7 procedures procedure NNS cord-010092-uftc8inx 12621 8 , , , cord-010092-uftc8inx 12621 9 five five CD cord-010092-uftc8inx 12621 10 ( ( -LRB- cord-010092-uftc8inx 12621 11 14.3 14.3 CD cord-010092-uftc8inx 12621 12 % % NN cord-010092-uftc8inx 12621 13 ) ) -RRB- cord-010092-uftc8inx 12621 14 patients patient NNS cord-010092-uftc8inx 12621 15 presented present VBN cord-010092-uftc8inx 12621 16 with with IN cord-010092-uftc8inx 12621 17 allergic allergic JJ cord-010092-uftc8inx 12621 18 or or CC cord-010092-uftc8inx 12621 19 hypotensive hypotensive JJ cord-010092-uftc8inx 12621 20 reactions reaction NNS cord-010092-uftc8inx 12621 21 which which WDT cord-010092-uftc8inx 12621 22 were be VBD cord-010092-uftc8inx 12621 23 managed manage VBN cord-010092-uftc8inx 12621 24 conservatively conservatively RB cord-010092-uftc8inx 12621 25 . . . cord-010092-uftc8inx 12622 1 Most Most JJS cord-010092-uftc8inx 12622 2 of of IN cord-010092-uftc8inx 12622 3 the the DT cord-010092-uftc8inx 12622 4 patients patient NNS cord-010092-uftc8inx 12622 5 were be VBD cord-010092-uftc8inx 12622 6 discharged discharge VBN cord-010092-uftc8inx 12622 7 after after IN cord-010092-uftc8inx 12622 8 seven seven CD cord-010092-uftc8inx 12622 9 days day NNS cord-010092-uftc8inx 12622 10 of of IN cord-010092-uftc8inx 12622 11 hospital hospital NN cord-010092-uftc8inx 12622 12 stay stay NN cord-010092-uftc8inx 12622 13 whereas whereas IN cord-010092-uftc8inx 12622 14 patients patient NNS cord-010092-uftc8inx 12622 15 who who WP cord-010092-uftc8inx 12622 16 required require VBD cord-010092-uftc8inx 12622 17 post post JJ cord-010092-uftc8inx 12622 18 - - JJ cord-010092-uftc8inx 12622 19 transplant transplant NN cord-010092-uftc8inx 12622 20 TPE TPE NNP cord-010092-uftc8inx 12622 21 were be VBD cord-010092-uftc8inx 12622 22 discharged discharge VBN cord-010092-uftc8inx 12622 23 after after IN cord-010092-uftc8inx 12622 24 a a DT cord-010092-uftc8inx 12622 25 relatively relatively RB cord-010092-uftc8inx 12622 26 longer long JJR cord-010092-uftc8inx 12622 27 hospital hospital NN cord-010092-uftc8inx 12622 28 stay stay NN cord-010092-uftc8inx 12622 29 ( ( -LRB- cord-010092-uftc8inx 12622 30 mean-8.5 mean-8.5 VB cord-010092-uftc8inx 12622 31 , , , cord-010092-uftc8inx 12622 32 median-7 median-7 NNP cord-010092-uftc8inx 12622 33 days day NNS cord-010092-uftc8inx 12622 34 ) ) -RRB- cord-010092-uftc8inx 12622 35 . . . cord-010092-uftc8inx 12623 1 After after IN cord-010092-uftc8inx 12623 2 three three CD cord-010092-uftc8inx 12623 3 months month NNS cord-010092-uftc8inx 12623 4 , , , cord-010092-uftc8inx 12623 5 protocol protocol NN cord-010092-uftc8inx 12623 6 biopsy biopsy NN cord-010092-uftc8inx 12623 7 was be VBD cord-010092-uftc8inx 12623 8 done do VBN cord-010092-uftc8inx 12623 9 in in IN cord-010092-uftc8inx 12623 10 those those DT cord-010092-uftc8inx 12623 11 cases case NNS cord-010092-uftc8inx 12623 12 only only RB cord-010092-uftc8inx 12623 13 where where WRB cord-010092-uftc8inx 12623 14 post post NN cord-010092-uftc8inx 12623 15 transplant transplant NN cord-010092-uftc8inx 12623 16 TPE TPE NNP cord-010092-uftc8inx 12623 17 was be VBD cord-010092-uftc8inx 12623 18 required require VBN cord-010092-uftc8inx 12623 19 . . . cord-010092-uftc8inx 12624 1 Protocol protocol NN cord-010092-uftc8inx 12624 2 biopsy biopsy NN cord-010092-uftc8inx 12624 3 showed show VBD cord-010092-uftc8inx 12624 4 normal normal JJ cord-010092-uftc8inx 12624 5 findings finding NNS cord-010092-uftc8inx 12624 6 . . . cord-010092-uftc8inx 12625 1 In in IN cord-010092-uftc8inx 12625 2 present present JJ cord-010092-uftc8inx 12625 3 study study NN cord-010092-uftc8inx 12625 4 , , , cord-010092-uftc8inx 12625 5 the the DT cord-010092-uftc8inx 12625 6 mean mean JJ cord-010092-uftc8inx 12625 7 duration duration NN cord-010092-uftc8inx 12625 8 of of IN cord-010092-uftc8inx 12625 9 follow follow NN cord-010092-uftc8inx 12625 10 up up RP cord-010092-uftc8inx 12625 11 was be VBD cord-010092-uftc8inx 12625 12 approx approx NN cord-010092-uftc8inx 12625 13 17 17 CD cord-010092-uftc8inx 12625 14 months month NNS cord-010092-uftc8inx 12625 15 with with IN cord-010092-uftc8inx 12625 16 the the DT cord-010092-uftc8inx 12625 17 longest long JJS cord-010092-uftc8inx 12625 18 duration duration NN cord-010092-uftc8inx 12625 19 of of IN cord-010092-uftc8inx 12625 20 follow follow NN cord-010092-uftc8inx 12625 21 up up IN cord-010092-uftc8inx 12625 22 of of IN cord-010092-uftc8inx 12625 23 36 36 CD cord-010092-uftc8inx 12625 24 months month NNS cord-010092-uftc8inx 12625 25 . . . cord-010092-uftc8inx 12626 1 Summary Summary NNP cord-010092-uftc8inx 12626 2 / / SYM cord-010092-uftc8inx 12626 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 12626 4 : : : cord-010092-uftc8inx 12627 1 In in IN cord-010092-uftc8inx 12627 2 a a DT cord-010092-uftc8inx 12627 3 country country NN cord-010092-uftc8inx 12627 4 like like IN cord-010092-uftc8inx 12627 5 India India NNP cord-010092-uftc8inx 12627 6 where where WRB cord-010092-uftc8inx 12627 7 there there EX cord-010092-uftc8inx 12627 8 is be VBZ cord-010092-uftc8inx 12627 9 a a DT cord-010092-uftc8inx 12627 10 huge huge JJ cord-010092-uftc8inx 12627 11 gap gap NN cord-010092-uftc8inx 12627 12 in in IN cord-010092-uftc8inx 12627 13 the the DT cord-010092-uftc8inx 12627 14 demand demand NN cord-010092-uftc8inx 12627 15 and and CC cord-010092-uftc8inx 12627 16 supply supply NN cord-010092-uftc8inx 12627 17 of of IN cord-010092-uftc8inx 12627 18 Kidney kidney NN cord-010092-uftc8inx 12627 19 and and CC cord-010092-uftc8inx 12627 20 a a DT cord-010092-uftc8inx 12627 21 large large JJ cord-010092-uftc8inx 12627 22 no no NN cord-010092-uftc8inx 12627 23 . . . cord-010092-uftc8inx 12628 1 of of IN cord-010092-uftc8inx 12628 2 patients patient NNS cord-010092-uftc8inx 12628 3 waiting wait VBG cord-010092-uftc8inx 12628 4 for for IN cord-010092-uftc8inx 12628 5 a a DT cord-010092-uftc8inx 12628 6 suitable suitable JJ cord-010092-uftc8inx 12628 7 organ organ NN cord-010092-uftc8inx 12628 8 , , , cord-010092-uftc8inx 12628 9 transplant transplant NN cord-010092-uftc8inx 12628 10 across across IN cord-010092-uftc8inx 12628 11 HLA HLA NNP cord-010092-uftc8inx 12628 12 barrier barrier NN cord-010092-uftc8inx 12628 13 could could MD cord-010092-uftc8inx 12628 14 a a DT cord-010092-uftc8inx 12628 15 good good JJ cord-010092-uftc8inx 12628 16 doable doable JJ cord-010092-uftc8inx 12628 17 option option NN cord-010092-uftc8inx 12628 18 . . . cord-010092-uftc8inx 12629 1 Thorough thorough JJ cord-010092-uftc8inx 12629 2 pretransplant pretransplant JJ cord-010092-uftc8inx 12629 3 compatibility compatibility NN cord-010092-uftc8inx 12629 4 and and CC cord-010092-uftc8inx 12629 5 TPE TPE NNP cord-010092-uftc8inx 12629 6 are be VBP cord-010092-uftc8inx 12629 7 essential essential JJ cord-010092-uftc8inx 12629 8 tools tool NNS cord-010092-uftc8inx 12629 9 to to TO cord-010092-uftc8inx 12629 10 make make VB cord-010092-uftc8inx 12629 11 these these DT cord-010092-uftc8inx 12629 12 transplants transplant NNS cord-010092-uftc8inx 12629 13 program program NN cord-010092-uftc8inx 12629 14 successful successful JJ cord-010092-uftc8inx 12629 15 Background background NN cord-010092-uftc8inx 12629 16 : : : cord-010092-uftc8inx 12629 17 Most Most JJS cord-010092-uftc8inx 12629 18 transfusion transfusion NN cord-010092-uftc8inx 12629 19 - - HYPH cord-010092-uftc8inx 12629 20 dependent dependent JJ cord-010092-uftc8inx 12629 21 chronically chronically RB cord-010092-uftc8inx 12629 22 anemic anemic JJ cord-010092-uftc8inx 12629 23 patients patient NNS cord-010092-uftc8inx 12629 24 are be VBP cord-010092-uftc8inx 12629 25 managed manage VBN cord-010092-uftc8inx 12629 26 by by IN cord-010092-uftc8inx 12629 27 simple simple JJ cord-010092-uftc8inx 12629 28 red red JJ cord-010092-uftc8inx 12629 29 cell cell NN cord-010092-uftc8inx 12629 30 transfusions transfusion NNS cord-010092-uftc8inx 12629 31 . . . cord-010092-uftc8inx 12630 1 However however RB cord-010092-uftc8inx 12630 2 , , , cord-010092-uftc8inx 12630 3 some some DT cord-010092-uftc8inx 12630 4 patients patient NNS cord-010092-uftc8inx 12630 5 are be VBP cord-010092-uftc8inx 12630 6 not not RB cord-010092-uftc8inx 12630 7 able able JJ cord-010092-uftc8inx 12630 8 to to TO cord-010092-uftc8inx 12630 9 tolerate tolerate VB cord-010092-uftc8inx 12630 10 the the DT cord-010092-uftc8inx 12630 11 additional additional JJ cord-010092-uftc8inx 12630 12 volume volume NN cord-010092-uftc8inx 12630 13 associated associate VBN cord-010092-uftc8inx 12630 14 with with IN cord-010092-uftc8inx 12630 15 simple simple JJ cord-010092-uftc8inx 12630 16 transfusions transfusion NNS cord-010092-uftc8inx 12630 17 and and CC cord-010092-uftc8inx 12630 18 are be VBP cord-010092-uftc8inx 12630 19 at at IN cord-010092-uftc8inx 12630 20 a a DT cord-010092-uftc8inx 12630 21 high high JJ cord-010092-uftc8inx 12630 22 risk risk NN cord-010092-uftc8inx 12630 23 of of IN cord-010092-uftc8inx 12630 24 developing develop VBG cord-010092-uftc8inx 12630 25 transfusion transfusion NN cord-010092-uftc8inx 12630 26 associated associate VBD cord-010092-uftc8inx 12630 27 circulatory circulatory JJ cord-010092-uftc8inx 12630 28 overload overload NN cord-010092-uftc8inx 12630 29 , , , cord-010092-uftc8inx 12630 30 if if IN cord-010092-uftc8inx 12630 31 transfused transfuse VBN cord-010092-uftc8inx 12630 32 with with IN cord-010092-uftc8inx 12630 33 multiple multiple JJ cord-010092-uftc8inx 12630 34 red red JJ cord-010092-uftc8inx 12630 35 cell cell NN cord-010092-uftc8inx 12630 36 units unit NNS cord-010092-uftc8inx 12630 37 . . . cord-010092-uftc8inx 12631 1 Plasma plasma NN cord-010092-uftc8inx 12631 2 - - HYPH cord-010092-uftc8inx 12631 3 to to IN cord-010092-uftc8inx 12631 4 red red JJ cord-010092-uftc8inx 12631 5 cell cell NN cord-010092-uftc8inx 12631 6 exchange exchange NN cord-010092-uftc8inx 12631 7 ( ( -LRB- cord-010092-uftc8inx 12631 8 PRX PRX NNP cord-010092-uftc8inx 12631 9 ) ) -RRB- cord-010092-uftc8inx 12631 10 is be VBZ cord-010092-uftc8inx 12631 11 a a DT cord-010092-uftc8inx 12631 12 modified modify VBN cord-010092-uftc8inx 12631 13 procedure procedure NN cord-010092-uftc8inx 12631 14 wherein wherein WRB cord-010092-uftc8inx 12631 15 an an DT cord-010092-uftc8inx 12631 16 apheresis apheresis NN cord-010092-uftc8inx 12631 17 machine machine NN cord-010092-uftc8inx 12631 18 is be VBZ cord-010092-uftc8inx 12631 19 used use VBN cord-010092-uftc8inx 12631 20 to to TO cord-010092-uftc8inx 12631 21 remove remove VB cord-010092-uftc8inx 12631 22 patient patient NN cord-010092-uftc8inx 12631 23 's 's POS cord-010092-uftc8inx 12631 24 plasma plasma NN cord-010092-uftc8inx 12631 25 , , , cord-010092-uftc8inx 12631 26 while while IN cord-010092-uftc8inx 12631 27 simultaneously simultaneously RB cord-010092-uftc8inx 12631 28 replacing replace VBG cord-010092-uftc8inx 12631 29 with with IN cord-010092-uftc8inx 12631 30 donor donor NN cord-010092-uftc8inx 12631 31 RBCs rbc NNS cord-010092-uftc8inx 12631 32 . . . cord-010092-uftc8inx 12632 1 This this DT cord-010092-uftc8inx 12632 2 procedure procedure NN cord-010092-uftc8inx 12632 3 allows allow VBZ cord-010092-uftc8inx 12632 4 for for IN cord-010092-uftc8inx 12632 5 a a DT cord-010092-uftc8inx 12632 6 rapid rapid JJ cord-010092-uftc8inx 12632 7 euvolemic euvolemic JJ cord-010092-uftc8inx 12632 8 transfusion transfusion NN cord-010092-uftc8inx 12632 9 of of IN cord-010092-uftc8inx 12632 10 RBCs rbc NNS cord-010092-uftc8inx 12632 11 to to IN cord-010092-uftc8inx 12632 12 patients patient NNS cord-010092-uftc8inx 12632 13 that that WDT cord-010092-uftc8inx 12632 14 are be VBP cord-010092-uftc8inx 12632 15 severely severely RB cord-010092-uftc8inx 12632 16 anemic anemic JJ cord-010092-uftc8inx 12632 17 and and CC cord-010092-uftc8inx 12632 18 intolerant intolerant JJ cord-010092-uftc8inx 12632 19 to to IN cord-010092-uftc8inx 12632 20 excess excess JJ cord-010092-uftc8inx 12632 21 fluid fluid JJ cord-010092-uftc8inx 12632 22 volume volume NN cord-010092-uftc8inx 12632 23 . . . cord-010092-uftc8inx 12633 1 Others other NNS cord-010092-uftc8inx 12633 2 as as RB cord-010092-uftc8inx 12633 3 well well RB cord-010092-uftc8inx 12633 4 as as IN cord-010092-uftc8inx 12633 5 our -PRON- PRP$ cord-010092-uftc8inx 12633 6 group group NN cord-010092-uftc8inx 12633 7 have have VBP cord-010092-uftc8inx 12633 8 previously previously RB cord-010092-uftc8inx 12633 9 described describe VBN cord-010092-uftc8inx 12633 10 this this DT cord-010092-uftc8inx 12633 11 procedure procedure NN cord-010092-uftc8inx 12633 12 . . . cord-010092-uftc8inx 12634 1 We -PRON- PRP cord-010092-uftc8inx 12634 2 now now RB cord-010092-uftc8inx 12634 3 summarize summarize VBP cord-010092-uftc8inx 12634 4 our -PRON- PRP$ cord-010092-uftc8inx 12634 5 institutions institution NNS cord-010092-uftc8inx 12634 6 nearly nearly RB cord-010092-uftc8inx 12634 7 seven seven CD cord-010092-uftc8inx 12634 8 years year NNS cord-010092-uftc8inx 12634 9 of of IN cord-010092-uftc8inx 12634 10 experience experience NN cord-010092-uftc8inx 12634 11 performing perform VBG cord-010092-uftc8inx 12634 12 this this DT cord-010092-uftc8inx 12634 13 procedure procedure NN cord-010092-uftc8inx 12634 14 on on IN cord-010092-uftc8inx 12634 15 a a DT cord-010092-uftc8inx 12634 16 routine routine JJ cord-010092-uftc8inx 12634 17 basis basis NN cord-010092-uftc8inx 12634 18 . . . cord-010092-uftc8inx 12635 1 Aims aim VBZ cord-010092-uftc8inx 12635 2 : : : cord-010092-uftc8inx 12636 1 To to TO cord-010092-uftc8inx 12636 2 document document VB cord-010092-uftc8inx 12636 3 patient patient JJ cord-010092-uftc8inx 12636 4 experience experience NN cord-010092-uftc8inx 12636 5 with with IN cord-010092-uftc8inx 12636 6 PRX PRX NNP cord-010092-uftc8inx 12636 7 . . . cord-010092-uftc8inx 12637 1 Methods method NNS cord-010092-uftc8inx 12637 2 : : : cord-010092-uftc8inx 12638 1 We -PRON- PRP cord-010092-uftc8inx 12638 2 performed perform VBD cord-010092-uftc8inx 12638 3 a a DT cord-010092-uftc8inx 12638 4 retrospective retrospective JJ cord-010092-uftc8inx 12638 5 chart chart NN cord-010092-uftc8inx 12638 6 review review NN cord-010092-uftc8inx 12638 7 of of IN cord-010092-uftc8inx 12638 8 all all DT cord-010092-uftc8inx 12638 9 patients patient NNS cord-010092-uftc8inx 12638 10 that that WDT cord-010092-uftc8inx 12638 11 underwent undergo VBD cord-010092-uftc8inx 12638 12 PRX PRX NNP cord-010092-uftc8inx 12638 13 at at IN cord-010092-uftc8inx 12638 14 our -PRON- PRP$ cord-010092-uftc8inx 12638 15 institution institution NN cord-010092-uftc8inx 12638 16 in in IN cord-010092-uftc8inx 12638 17 the the DT cord-010092-uftc8inx 12638 18 last last JJ cord-010092-uftc8inx 12638 19 seven seven CD cord-010092-uftc8inx 12638 20 years year NNS cord-010092-uftc8inx 12638 21 . . . cord-010092-uftc8inx 12639 1 Our -PRON- PRP$ cord-010092-uftc8inx 12639 2 protocol protocol NN cord-010092-uftc8inx 12639 3 for for IN cord-010092-uftc8inx 12639 4 PRX PRX NNP cord-010092-uftc8inx 12639 5 has have VBZ cord-010092-uftc8inx 12639 6 evolved evolve VBN cord-010092-uftc8inx 12639 7 during during IN cord-010092-uftc8inx 12639 8 this this DT cord-010092-uftc8inx 12639 9 period period NN cord-010092-uftc8inx 12639 10 . . . cord-010092-uftc8inx 12640 1 Currently currently RB cord-010092-uftc8inx 12640 2 , , , cord-010092-uftc8inx 12640 3 we -PRON- PRP cord-010092-uftc8inx 12640 4 perform perform VBP cord-010092-uftc8inx 12640 5 the the DT cord-010092-uftc8inx 12640 6 procedures procedure NNS cord-010092-uftc8inx 12640 7 using use VBG cord-010092-uftc8inx 12640 8 Spectra Spectra NNP cord-010092-uftc8inx 12640 9 Optia Optia NNP cord-010092-uftc8inx 12640 10 ( ( -LRB- cord-010092-uftc8inx 12640 11 Terumo Terumo NNP cord-010092-uftc8inx 12640 12 BCT BCT NNP cord-010092-uftc8inx 12640 13 , , , cord-010092-uftc8inx 12640 14 Lakewood Lakewood NNP cord-010092-uftc8inx 12640 15 , , , cord-010092-uftc8inx 12640 16 CO CO NNP cord-010092-uftc8inx 12640 17 ) ) -RRB- cord-010092-uftc8inx 12640 18 machine machine NN cord-010092-uftc8inx 12640 19 using use VBG cord-010092-uftc8inx 12640 20 the the DT cord-010092-uftc8inx 12640 21 plasma plasma NN cord-010092-uftc8inx 12640 22 - - HYPH cord-010092-uftc8inx 12640 23 exchange exchange NN cord-010092-uftc8inx 12640 24 program program NN cord-010092-uftc8inx 12640 25 and and CC cord-010092-uftc8inx 12640 26 tubing tubing NN cord-010092-uftc8inx 12640 27 set set VBN cord-010092-uftc8inx 12640 28 . . . cord-010092-uftc8inx 12641 1 If if IN cord-010092-uftc8inx 12641 2 the the DT cord-010092-uftc8inx 12641 3 patient patient NN cord-010092-uftc8inx 12641 4 's 's POS cord-010092-uftc8inx 12641 5 pre pre JJ cord-010092-uftc8inx 12641 6 - - JJ cord-010092-uftc8inx 12641 7 procedure procedure JJ cord-010092-uftc8inx 12641 8 hematocrit hematocrit NN cord-010092-uftc8inx 12641 9 ( ( -LRB- cord-010092-uftc8inx 12641 10 Hct Hct NNP cord-010092-uftc8inx 12641 11 ) ) -RRB- cord-010092-uftc8inx 12641 12 is be VBZ cord-010092-uftc8inx 12641 13 < < XX cord-010092-uftc8inx 12641 14 22 22 CD cord-010092-uftc8inx 12641 15 % % NN cord-010092-uftc8inx 12641 16 , , , cord-010092-uftc8inx 12641 17 we -PRON- PRP cord-010092-uftc8inx 12641 18 custom custom VBP cord-010092-uftc8inx 12641 19 prime prime VBP cord-010092-uftc8inx 12641 20 the the DT cord-010092-uftc8inx 12641 21 tubing tubing NN cord-010092-uftc8inx 12641 22 set set VBN cord-010092-uftc8inx 12641 23 with with IN cord-010092-uftc8inx 12641 24 5 5 CD cord-010092-uftc8inx 12641 25 % % NN cord-010092-uftc8inx 12641 26 albumin albumin NN cord-010092-uftc8inx 12641 27 . . . cord-010092-uftc8inx 12642 1 The the DT cord-010092-uftc8inx 12642 2 number number NN cord-010092-uftc8inx 12642 3 of of IN cord-010092-uftc8inx 12642 4 red red JJ cord-010092-uftc8inx 12642 5 cell cell NN cord-010092-uftc8inx 12642 6 units unit NNS cord-010092-uftc8inx 12642 7 transfused transfuse VBN cord-010092-uftc8inx 12642 8 to to IN cord-010092-uftc8inx 12642 9 the the DT cord-010092-uftc8inx 12642 10 patient patient NN cord-010092-uftc8inx 12642 11 depends depend VBZ cord-010092-uftc8inx 12642 12 on on IN cord-010092-uftc8inx 12642 13 their -PRON- PRP$ cord-010092-uftc8inx 12642 14 pre pre JJ cord-010092-uftc8inx 12642 15 - - JJ cord-010092-uftc8inx 12642 16 procedure procedure JJ cord-010092-uftc8inx 12642 17 hematocrit hematocrit NN cord-010092-uftc8inx 12642 18 and and CC cord-010092-uftc8inx 12642 19 is be VBZ cord-010092-uftc8inx 12642 20 individualized individualize VBN cord-010092-uftc8inx 12642 21 to to IN cord-010092-uftc8inx 12642 22 the the DT cord-010092-uftc8inx 12642 23 patients patient NNS cord-010092-uftc8inx 12642 24 . . . cord-010092-uftc8inx 12643 1 Results result NNS cord-010092-uftc8inx 12643 2 : : : cord-010092-uftc8inx 12644 1 We -PRON- PRP cord-010092-uftc8inx 12644 2 have have VBP cord-010092-uftc8inx 12644 3 treated treat VBN cord-010092-uftc8inx 12644 4 four four CD cord-010092-uftc8inx 12644 5 patients patient NNS cord-010092-uftc8inx 12644 6 with with IN cord-010092-uftc8inx 12644 7 PRX PRX NNP cord-010092-uftc8inx 12644 8 procedure procedure NN cord-010092-uftc8inx 12644 9 . . . cord-010092-uftc8inx 12645 1 Patient patient NN cord-010092-uftc8inx 12645 2 # # NN cord-010092-uftc8inx 12645 3 1 1 CD cord-010092-uftc8inx 12645 4 is be VBZ cord-010092-uftc8inx 12645 5 a a DT cord-010092-uftc8inx 12645 6 56-year 56-year JJ cord-010092-uftc8inx 12645 7 - - HYPH cord-010092-uftc8inx 12645 8 old old JJ cord-010092-uftc8inx 12645 9 transfusion transfusion NN cord-010092-uftc8inx 12645 10 - - HYPH cord-010092-uftc8inx 12645 11 dependent dependent JJ cord-010092-uftc8inx 12645 12 male male NN cord-010092-uftc8inx 12645 13 with with IN cord-010092-uftc8inx 12645 14 beta beta NN cord-010092-uftc8inx 12645 15 - - HYPH cord-010092-uftc8inx 12645 16 thalassemia thalassemia NN cord-010092-uftc8inx 12645 17 major major NN cord-010092-uftc8inx 12645 18 . . . cord-010092-uftc8inx 12646 1 The the DT cord-010092-uftc8inx 12646 2 patient patient NN cord-010092-uftc8inx 12646 3 had have VBD cord-010092-uftc8inx 12646 4 experienced experience VBN cord-010092-uftc8inx 12646 5 multiple multiple JJ cord-010092-uftc8inx 12646 6 congestive congestive JJ cord-010092-uftc8inx 12646 7 heart heart NN cord-010092-uftc8inx 12646 8 failure failure NN cord-010092-uftc8inx 12646 9 exacerbations exacerbation NNS cord-010092-uftc8inx 12646 10 secondary secondary JJ cord-010092-uftc8inx 12646 11 to to IN cord-010092-uftc8inx 12646 12 simple simple JJ cord-010092-uftc8inx 12646 13 transfusions transfusion NNS cord-010092-uftc8inx 12647 1 and and CC cord-010092-uftc8inx 12647 2 we -PRON- PRP cord-010092-uftc8inx 12647 3 consequently consequently RB cord-010092-uftc8inx 12647 4 performed perform VBD cord-010092-uftc8inx 12647 5 PRX PRX NNP cord-010092-uftc8inx 12647 6 procedure procedure NN cord-010092-uftc8inx 12647 7 , , , cord-010092-uftc8inx 12647 8 every every DT cord-010092-uftc8inx 12647 9 4 4 CD cord-010092-uftc8inx 12647 10 weeks week NNS cord-010092-uftc8inx 12647 11 , , , cord-010092-uftc8inx 12647 12 starting start VBG cord-010092-uftc8inx 12647 13 in in IN cord-010092-uftc8inx 12647 14 2012 2012 CD cord-010092-uftc8inx 12647 15 . . . cord-010092-uftc8inx 12648 1 The the DT cord-010092-uftc8inx 12648 2 patient patient NN cord-010092-uftc8inx 12648 3 has have VBZ cord-010092-uftc8inx 12648 4 completed complete VBN cord-010092-uftc8inx 12648 5 84 84 CD cord-010092-uftc8inx 12648 6 procedures procedure NNS cord-010092-uftc8inx 12648 7 with with IN cord-010092-uftc8inx 12648 8 3 3 CD cord-010092-uftc8inx 12648 9 - - SYM cord-010092-uftc8inx 12648 10 4 4 CD cord-010092-uftc8inx 12648 11 units unit NNS cord-010092-uftc8inx 12648 12 of of IN cord-010092-uftc8inx 12648 13 washed wash VBN cord-010092-uftc8inx 12648 14 red red JJ cord-010092-uftc8inx 12648 15 cells cell NNS cord-010092-uftc8inx 12648 16 transfused transfuse VBN cord-010092-uftc8inx 12648 17 to to TO cord-010092-uftc8inx 12648 18 achieve achieve VB cord-010092-uftc8inx 12648 19 a a DT cord-010092-uftc8inx 12648 20 target target NN cord-010092-uftc8inx 12648 21 HCT hct NN cord-010092-uftc8inx 12648 22 goal goal NN cord-010092-uftc8inx 12648 23 of of IN cord-010092-uftc8inx 12648 24 45 45 CD cord-010092-uftc8inx 12648 25 to to TO cord-010092-uftc8inx 12648 26 57 57 CD cord-010092-uftc8inx 12648 27 % % NN cord-010092-uftc8inx 12648 28 . . . cord-010092-uftc8inx 12649 1 He -PRON- PRP cord-010092-uftc8inx 12649 2 tolerated tolerate VBD cord-010092-uftc8inx 12649 3 all all DT cord-010092-uftc8inx 12649 4 procedures procedure NNS cord-010092-uftc8inx 12649 5 without without IN cord-010092-uftc8inx 12649 6 any any DT cord-010092-uftc8inx 12649 7 volume volume NN cord-010092-uftc8inx 12649 8 overload overload NN cord-010092-uftc8inx 12649 9 issues issue NNS cord-010092-uftc8inx 12649 10 . . . cord-010092-uftc8inx 12650 1 He -PRON- PRP cord-010092-uftc8inx 12650 2 continues continue VBZ cord-010092-uftc8inx 12650 3 on on IN cord-010092-uftc8inx 12650 4 this this DT cord-010092-uftc8inx 12650 5 transfusion transfusion NN cord-010092-uftc8inx 12650 6 regimen regimen NN cord-010092-uftc8inx 12650 7 . . . cord-010092-uftc8inx 12651 1 Patient patient NN cord-010092-uftc8inx 12651 2 # # $ cord-010092-uftc8inx 12651 3 2 2 CD cord-010092-uftc8inx 12651 4 was be VBD cord-010092-uftc8inx 12651 5 a a DT cord-010092-uftc8inx 12651 6 25-year 25-year JJ cord-010092-uftc8inx 12651 7 - - HYPH cord-010092-uftc8inx 12651 8 old old JJ cord-010092-uftc8inx 12651 9 female female NN cord-010092-uftc8inx 12651 10 who who WP cord-010092-uftc8inx 12651 11 had have VBD cord-010092-uftc8inx 12651 12 symptomatic symptomatic JJ cord-010092-uftc8inx 12651 13 anemia anemia NN cord-010092-uftc8inx 12651 14 secondary secondary JJ cord-010092-uftc8inx 12651 15 to to IN cord-010092-uftc8inx 12651 16 sickle sickle VB cord-010092-uftc8inx 12651 17 cell cell NN cord-010092-uftc8inx 12651 18 disease disease NN cord-010092-uftc8inx 12652 1 ( ( -LRB- cord-010092-uftc8inx 12652 2 Hb Hb NNP cord-010092-uftc8inx 12652 3 SS SS NNP cord-010092-uftc8inx 12652 4 complicated complicate VBN cord-010092-uftc8inx 12652 5 by by IN cord-010092-uftc8inx 12652 6 end end NN cord-010092-uftc8inx 12652 7 - - HYPH cord-010092-uftc8inx 12652 8 stage stage NN cord-010092-uftc8inx 12652 9 renal renal JJ cord-010092-uftc8inx 12652 10 disease disease NN cord-010092-uftc8inx 12652 11 ( ( -LRB- cord-010092-uftc8inx 12652 12 ESRD ESRD NNP cord-010092-uftc8inx 12652 13 ) ) -RRB- cord-010092-uftc8inx 12652 14 . . . cord-010092-uftc8inx 12653 1 She -PRON- PRP cord-010092-uftc8inx 12653 2 had have VBD cord-010092-uftc8inx 12653 3 progressively progressively RB cord-010092-uftc8inx 12653 4 become become VBN cord-010092-uftc8inx 12653 5 intolerant intolerant JJ cord-010092-uftc8inx 12653 6 to to IN cord-010092-uftc8inx 12653 7 simple simple JJ cord-010092-uftc8inx 12653 8 transfusions transfusion NNS cord-010092-uftc8inx 12653 9 , , , cord-010092-uftc8inx 12653 10 including include VBG cord-010092-uftc8inx 12653 11 an an DT cord-010092-uftc8inx 12653 12 episode episode NN cord-010092-uftc8inx 12653 13 of of IN cord-010092-uftc8inx 12653 14 severe severe JJ cord-010092-uftc8inx 12653 15 dyspnea dyspnea NN cord-010092-uftc8inx 12653 16 , , , cord-010092-uftc8inx 12653 17 which which WDT cord-010092-uftc8inx 12653 18 required require VBD cord-010092-uftc8inx 12653 19 intubation intubation NN cord-010092-uftc8inx 12653 20 . . . cord-010092-uftc8inx 12654 1 She -PRON- PRP cord-010092-uftc8inx 12654 2 underwent undergo VBD cord-010092-uftc8inx 12654 3 9 9 CD cord-010092-uftc8inx 12654 4 PRX PRX NNP cord-010092-uftc8inx 12654 5 procedures procedure NNS cord-010092-uftc8inx 12654 6 with with IN cord-010092-uftc8inx 12654 7 2 2 CD cord-010092-uftc8inx 12654 8 - - SYM cord-010092-uftc8inx 12654 9 3 3 CD cord-010092-uftc8inx 12654 10 units unit NNS cord-010092-uftc8inx 12654 11 of of IN cord-010092-uftc8inx 12654 12 washed wash VBN cord-010092-uftc8inx 12654 13 red red JJ cord-010092-uftc8inx 12654 14 cells cell NNS cord-010092-uftc8inx 12654 15 . . . cord-010092-uftc8inx 12655 1 Patient Patient NNP cord-010092-uftc8inx 12655 2 tolerated tolerate VBD cord-010092-uftc8inx 12655 3 the the DT cord-010092-uftc8inx 12655 4 procedures procedure NNS cord-010092-uftc8inx 12655 5 without without IN cord-010092-uftc8inx 12655 6 any any DT cord-010092-uftc8inx 12655 7 significant significant JJ cord-010092-uftc8inx 12655 8 complications complication NNS cord-010092-uftc8inx 12655 9 . . . cord-010092-uftc8inx 12656 1 However however RB cord-010092-uftc8inx 12656 2 , , , cord-010092-uftc8inx 12656 3 during during IN cord-010092-uftc8inx 12656 4 a a DT cord-010092-uftc8inx 12656 5 different different JJ cord-010092-uftc8inx 12656 6 surgical surgical JJ cord-010092-uftc8inx 12656 7 procedure procedure NN cord-010092-uftc8inx 12656 8 , , , cord-010092-uftc8inx 12656 9 she -PRON- PRP cord-010092-uftc8inx 12656 10 experienced experience VBD cord-010092-uftc8inx 12656 11 cardiac cardiac JJ cord-010092-uftc8inx 12656 12 arrest arrest NN cord-010092-uftc8inx 12656 13 and and CC cord-010092-uftc8inx 12656 14 subsequently subsequently RB cord-010092-uftc8inx 12656 15 passed pass VBD cord-010092-uftc8inx 12656 16 away away RB cord-010092-uftc8inx 12656 17 . . . cord-010092-uftc8inx 12657 1 Patient patient NN cord-010092-uftc8inx 12657 2 # # NN cord-010092-uftc8inx 12657 3 3 3 CD cord-010092-uftc8inx 12657 4 is be VBZ cord-010092-uftc8inx 12657 5 a a DT cord-010092-uftc8inx 12657 6 33-year 33-year JJ cord-010092-uftc8inx 12657 7 - - HYPH cord-010092-uftc8inx 12657 8 old old JJ cord-010092-uftc8inx 12657 9 transfusion transfusion NN cord-010092-uftc8inx 12657 10 - - HYPH cord-010092-uftc8inx 12657 11 dependent dependent JJ cord-010092-uftc8inx 12657 12 male male NN cord-010092-uftc8inx 12657 13 with with IN cord-010092-uftc8inx 12657 14 severe severe JJ cord-010092-uftc8inx 12657 15 anemia anemia NN cord-010092-uftc8inx 12657 16 secondary secondary JJ cord-010092-uftc8inx 12657 17 to to IN cord-010092-uftc8inx 12657 18 sickle sickle VB cord-010092-uftc8inx 12657 19 cell cell NN cord-010092-uftc8inx 12657 20 anemia anemia NN cord-010092-uftc8inx 12657 21 ( ( -LRB- cord-010092-uftc8inx 12657 22 Hb Hb NNP cord-010092-uftc8inx 12657 23 SS SS NNP cord-010092-uftc8inx 12657 24 ) ) -RRB- cord-010092-uftc8inx 12657 25 . . . cord-010092-uftc8inx 12658 1 He -PRON- PRP cord-010092-uftc8inx 12658 2 was be VBD cord-010092-uftc8inx 12658 3 intolerant intolerant JJ cord-010092-uftc8inx 12658 4 to to IN cord-010092-uftc8inx 12658 5 excess excess JJ cord-010092-uftc8inx 12658 6 fluid fluid NN cord-010092-uftc8inx 12658 7 because because IN cord-010092-uftc8inx 12658 8 of of IN cord-010092-uftc8inx 12658 9 ESRD ESRD NNP cord-010092-uftc8inx 12658 10 and and CC cord-010092-uftc8inx 12658 11 congestive congestive JJ cord-010092-uftc8inx 12658 12 heart heart NN cord-010092-uftc8inx 12658 13 failure failure NN cord-010092-uftc8inx 12658 14 . . . cord-010092-uftc8inx 12659 1 He -PRON- PRP cord-010092-uftc8inx 12659 2 has have VBZ cord-010092-uftc8inx 12659 3 undergone undergo VBN cord-010092-uftc8inx 12659 4 38 38 CD cord-010092-uftc8inx 12659 5 PRX PRX NNP cord-010092-uftc8inx 12659 6 procedures procedure NNS cord-010092-uftc8inx 12659 7 with with IN cord-010092-uftc8inx 12659 8 3 3 CD cord-010092-uftc8inx 12659 9 - - SYM cord-010092-uftc8inx 12659 10 5 5 CD cord-010092-uftc8inx 12659 11 red red JJ cord-010092-uftc8inx 12659 12 cell cell NN cord-010092-uftc8inx 12659 13 units unit NNS cord-010092-uftc8inx 12659 14 transfused transfuse VBN cord-010092-uftc8inx 12659 15 to to TO cord-010092-uftc8inx 12659 16 achieve achieve VB cord-010092-uftc8inx 12659 17 a a DT cord-010092-uftc8inx 12659 18 HCT HCT NNP cord-010092-uftc8inx 12659 19 goal goal NN cord-010092-uftc8inx 12659 20 of of IN cord-010092-uftc8inx 12659 21 30 30 CD cord-010092-uftc8inx 12659 22 % % NN cord-010092-uftc8inx 12659 23 . . . cord-010092-uftc8inx 12660 1 He -PRON- PRP cord-010092-uftc8inx 12660 2 tolerated tolerate VBD cord-010092-uftc8inx 12660 3 all all DT cord-010092-uftc8inx 12660 4 procedures procedure NNS cord-010092-uftc8inx 12660 5 without without IN cord-010092-uftc8inx 12660 6 any any DT cord-010092-uftc8inx 12660 7 volume volume NN cord-010092-uftc8inx 12660 8 overload overload NN cord-010092-uftc8inx 12660 9 issues issue NNS cord-010092-uftc8inx 12660 10 . . . cord-010092-uftc8inx 12661 1 He -PRON- PRP cord-010092-uftc8inx 12661 2 continues continue VBZ cord-010092-uftc8inx 12661 3 on on IN cord-010092-uftc8inx 12661 4 this this DT cord-010092-uftc8inx 12661 5 transfusion transfusion NN cord-010092-uftc8inx 12661 6 regimen regimen NN cord-010092-uftc8inx 12661 7 . . . cord-010092-uftc8inx 12662 1 Patient patient NN cord-010092-uftc8inx 12662 2 # # NN cord-010092-uftc8inx 12662 3 4 4 CD cord-010092-uftc8inx 12662 4 is be VBZ cord-010092-uftc8inx 12662 5 a a DT cord-010092-uftc8inx 12662 6 48-year 48-year JJ cord-010092-uftc8inx 12662 7 - - HYPH cord-010092-uftc8inx 12662 8 old old JJ cord-010092-uftc8inx 12662 9 male male NN cord-010092-uftc8inx 12662 10 with with IN cord-010092-uftc8inx 12662 11 a a DT cord-010092-uftc8inx 12662 12 sickle sickle NN cord-010092-uftc8inx 12662 13 cell cell NN cord-010092-uftc8inx 12662 14 disorder disorder NN cord-010092-uftc8inx 12662 15 ( ( -LRB- cord-010092-uftc8inx 12662 16 Hb Hb NNP cord-010092-uftc8inx 12662 17 SS SS NNP cord-010092-uftc8inx 12662 18 ) ) -RRB- cord-010092-uftc8inx 12662 19 complicated complicate VBN cord-010092-uftc8inx 12662 20 by by IN cord-010092-uftc8inx 12662 21 ESRD ESRD NNP cord-010092-uftc8inx 12662 22 , , , cord-010092-uftc8inx 12662 23 heart heart NN cord-010092-uftc8inx 12662 24 failure failure NN cord-010092-uftc8inx 12662 25 and and CC cord-010092-uftc8inx 12662 26 chronic chronic JJ cord-010092-uftc8inx 12662 27 hypoxemic hypoxemic JJ cord-010092-uftc8inx 12662 28 respiratory respiratory JJ cord-010092-uftc8inx 12662 29 failure failure NN cord-010092-uftc8inx 12662 30 . . . cord-010092-uftc8inx 12663 1 The the DT cord-010092-uftc8inx 12663 2 patient patient NN cord-010092-uftc8inx 12663 3 has have VBZ cord-010092-uftc8inx 12663 4 undergone undergo VBN cord-010092-uftc8inx 12663 5 two two CD cord-010092-uftc8inx 12663 6 PRX PRX NNP cord-010092-uftc8inx 12663 7 procedures procedure NNS cord-010092-uftc8inx 12663 8 with with IN cord-010092-uftc8inx 12663 9 4 4 CD cord-010092-uftc8inx 12663 10 - - SYM cord-010092-uftc8inx 12663 11 5 5 CD cord-010092-uftc8inx 12663 12 red red JJ cord-010092-uftc8inx 12663 13 cell cell NN cord-010092-uftc8inx 12663 14 units unit NNS cord-010092-uftc8inx 12663 15 . . . cord-010092-uftc8inx 12664 1 Other other JJ cord-010092-uftc8inx 12664 2 than than IN cord-010092-uftc8inx 12664 3 an an DT cord-010092-uftc8inx 12664 4 episode episode NN cord-010092-uftc8inx 12664 5 of of IN cord-010092-uftc8inx 12664 6 non non JJ cord-010092-uftc8inx 12664 7 - - JJ cord-010092-uftc8inx 12664 8 bloody bloody JJ cord-010092-uftc8inx 12664 9 emesis emesis NN cord-010092-uftc8inx 12664 10 that that WDT cord-010092-uftc8inx 12664 11 was be VBD cord-010092-uftc8inx 12664 12 symptomatically symptomatically RB cord-010092-uftc8inx 12664 13 treated treat VBN cord-010092-uftc8inx 12664 14 , , , cord-010092-uftc8inx 12664 15 he -PRON- PRP cord-010092-uftc8inx 12664 16 tolerated tolerate VBD cord-010092-uftc8inx 12664 17 both both DT cord-010092-uftc8inx 12664 18 procedures procedure NNS cord-010092-uftc8inx 12664 19 . . . cord-010092-uftc8inx 12665 1 He -PRON- PRP cord-010092-uftc8inx 12665 2 continues continue VBZ cord-010092-uftc8inx 12665 3 to to TO cord-010092-uftc8inx 12665 4 be be VB cord-010092-uftc8inx 12665 5 managed manage VBN cord-010092-uftc8inx 12665 6 on on IN cord-010092-uftc8inx 12665 7 this this DT cord-010092-uftc8inx 12665 8 regimen regimen NN cord-010092-uftc8inx 12665 9 . . . cord-010092-uftc8inx 12666 1 However however RB cord-010092-uftc8inx 12666 2 , , , cord-010092-uftc8inx 12666 3 the the DT cord-010092-uftc8inx 12666 4 patient patient NN cord-010092-uftc8inx 12666 5 remains remain VBZ cord-010092-uftc8inx 12666 6 noncompliant noncompliant JJ cord-010092-uftc8inx 12666 7 with with IN cord-010092-uftc8inx 12666 8 treatment treatment NN cord-010092-uftc8inx 12666 9 . . . cord-010092-uftc8inx 12667 1 Summary Summary NNP cord-010092-uftc8inx 12667 2 / / SYM cord-010092-uftc8inx 12667 3 Conclusions conclusion NNS cord-010092-uftc8inx 12667 4 : : : cord-010092-uftc8inx 12667 5 PRX PRX NNP cord-010092-uftc8inx 12667 6 is be VBZ cord-010092-uftc8inx 12667 7 a a DT cord-010092-uftc8inx 12667 8 safe safe JJ cord-010092-uftc8inx 12667 9 and and CC cord-010092-uftc8inx 12667 10 efficient efficient JJ cord-010092-uftc8inx 12667 11 method method NN cord-010092-uftc8inx 12667 12 to to TO cord-010092-uftc8inx 12667 13 transfuse transfuse VB cord-010092-uftc8inx 12667 14 multiple multiple JJ cord-010092-uftc8inx 12667 15 red red JJ cord-010092-uftc8inx 12667 16 cell cell NN cord-010092-uftc8inx 12667 17 units unit NNS cord-010092-uftc8inx 12667 18 to to IN cord-010092-uftc8inx 12667 19 volume volume NN cord-010092-uftc8inx 12667 20 - - HYPH cord-010092-uftc8inx 12667 21 intolerant intolerant JJ cord-010092-uftc8inx 12667 22 anemic anemic JJ cord-010092-uftc8inx 12667 23 patients patient NNS cord-010092-uftc8inx 12667 24 . . . cord-010092-uftc8inx 12668 1 Background background NN cord-010092-uftc8inx 12668 2 : : : cord-010092-uftc8inx 12669 1 Transplanted transplanted JJ cord-010092-uftc8inx 12669 2 organ organ NN cord-010092-uftc8inx 12669 3 failure failure NN cord-010092-uftc8inx 12669 4 due due JJ cord-010092-uftc8inx 12669 5 to to IN cord-010092-uftc8inx 12669 6 antibody antibody NN cord-010092-uftc8inx 12669 7 mediated mediate VBN cord-010092-uftc8inx 12669 8 rejection rejection NN cord-010092-uftc8inx 12669 9 in in IN cord-010092-uftc8inx 12669 10 ABO ABO NNP cord-010092-uftc8inx 12669 11 - - HYPH cord-010092-uftc8inx 12669 12 compatible compatible JJ cord-010092-uftc8inx 12669 13 organs organ NNS cord-010092-uftc8inx 12669 14 is be VBZ cord-010092-uftc8inx 12669 15 a a DT cord-010092-uftc8inx 12669 16 serious serious JJ cord-010092-uftc8inx 12669 17 complication complication NN cord-010092-uftc8inx 12669 18 with with IN cord-010092-uftc8inx 12669 19 a a DT cord-010092-uftc8inx 12669 20 bad bad JJ cord-010092-uftc8inx 12669 21 prognosis prognosis NN cord-010092-uftc8inx 12669 22 . . . cord-010092-uftc8inx 12670 1 The the DT cord-010092-uftc8inx 12670 2 goal goal NN cord-010092-uftc8inx 12670 3 treatment treatment NN cord-010092-uftc8inx 12670 4 in in IN cord-010092-uftc8inx 12670 5 these these DT cord-010092-uftc8inx 12670 6 cases case NNS cord-010092-uftc8inx 12670 7 encompasses encompass VBZ cord-010092-uftc8inx 12670 8 the the DT cord-010092-uftc8inx 12670 9 following follow VBG cord-010092-uftc8inx 12670 10 strategies strategy NNS cord-010092-uftc8inx 12670 11 : : : cord-010092-uftc8inx 12670 12 adjustment adjustment NN cord-010092-uftc8inx 12670 13 of of IN cord-010092-uftc8inx 12670 14 the the DT cord-010092-uftc8inx 12670 15 immunosuppressive immunosuppressive JJ cord-010092-uftc8inx 12670 16 medications medication NNS cord-010092-uftc8inx 12670 17 , , , cord-010092-uftc8inx 12670 18 IVIG IVIG NNP cord-010092-uftc8inx 12670 19 infusion infusion NN cord-010092-uftc8inx 12670 20 , , , cord-010092-uftc8inx 12670 21 antibody antibody NN cord-010092-uftc8inx 12670 22 removal removal NN cord-010092-uftc8inx 12670 23 by by IN cord-010092-uftc8inx 12670 24 therapeutic therapeutic JJ cord-010092-uftc8inx 12670 25 plasma plasma NN cord-010092-uftc8inx 12670 26 exchange exchange NN cord-010092-uftc8inx 12670 27 , , , cord-010092-uftc8inx 12670 28 and/or and/or CC cord-010092-uftc8inx 12670 29 the the DT cord-010092-uftc8inx 12670 30 use use NN cord-010092-uftc8inx 12670 31 of of IN cord-010092-uftc8inx 12670 32 target target NN cord-010092-uftc8inx 12670 33 - - HYPH cord-010092-uftc8inx 12670 34 specific specific JJ cord-010092-uftc8inx 12670 35 monoclonal monoclonal JJ cord-010092-uftc8inx 12670 36 antibody antibody NN cord-010092-uftc8inx 12670 37 medications medication NNS cord-010092-uftc8inx 12670 38 to to IN cord-010092-uftc8inx 12670 39 lymphocytes lymphocyte NNS cord-010092-uftc8inx 12670 40 , , , cord-010092-uftc8inx 12670 41 plasma plasma NN cord-010092-uftc8inx 12670 42 cells cell NNS cord-010092-uftc8inx 12670 43 , , , cord-010092-uftc8inx 12670 44 and/or and/or CC cord-010092-uftc8inx 12670 45 complement complement VB cord-010092-uftc8inx 12670 46 . . . cord-010092-uftc8inx 12671 1 The the DT cord-010092-uftc8inx 12671 2 2016 2016 CD cord-010092-uftc8inx 12671 3 American American NNP cord-010092-uftc8inx 12671 4 Society Society NNP cord-010092-uftc8inx 12671 5 for for IN cord-010092-uftc8inx 12671 6 Apheresis Apheresis NNP cord-010092-uftc8inx 12671 7 has have VBZ cord-010092-uftc8inx 12671 8 assigned assign VBN cord-010092-uftc8inx 12671 9 a a DT cord-010092-uftc8inx 12671 10 category category NN cord-010092-uftc8inx 12671 11 I -PRON- PRP cord-010092-uftc8inx 12671 12 to to IN cord-010092-uftc8inx 12671 13 the the DT cord-010092-uftc8inx 12671 14 use use NN cord-010092-uftc8inx 12671 15 of of IN cord-010092-uftc8inx 12671 16 therapeutic therapeutic JJ cord-010092-uftc8inx 12671 17 plasma plasma NN cord-010092-uftc8inx 12671 18 exchange exchange NN cord-010092-uftc8inx 12671 19 for for IN cord-010092-uftc8inx 12671 20 the the DT cord-010092-uftc8inx 12671 21 treatment treatment NN cord-010092-uftc8inx 12671 22 of of IN cord-010092-uftc8inx 12671 23 ABO ABO NNP cord-010092-uftc8inx 12671 24 - - HYPH cord-010092-uftc8inx 12671 25 compatible compatible JJ cord-010092-uftc8inx 12671 26 antibody antibody NN cord-010092-uftc8inx 12672 1 mediated mediate VBN cord-010092-uftc8inx 12672 2 rejection rejection NN cord-010092-uftc8inx 12672 3 in in IN cord-010092-uftc8inx 12672 4 kidney kidney NN cord-010092-uftc8inx 12672 5 , , , cord-010092-uftc8inx 12672 6 but but CC cord-010092-uftc8inx 12672 7 a a DT cord-010092-uftc8inx 12672 8 category category NN cord-010092-uftc8inx 12672 9 III iii CD cord-010092-uftc8inx 12672 10 to to IN cord-010092-uftc8inx 12672 11 all all DT cord-010092-uftc8inx 12672 12 other other JJ cord-010092-uftc8inx 12672 13 ABO ABO NNP cord-010092-uftc8inx 12672 14 compatible compatible JJ cord-010092-uftc8inx 12672 15 organs organ NNS cord-010092-uftc8inx 12672 16 : : : cord-010092-uftc8inx 12672 17 Liver liver NN cord-010092-uftc8inx 12672 18 , , , cord-010092-uftc8inx 12672 19 Lung Lung NNP cord-010092-uftc8inx 12672 20 , , , cord-010092-uftc8inx 12672 21 and and CC cord-010092-uftc8inx 12672 22 Heart heart NN cord-010092-uftc8inx 12672 23 . . . cord-010092-uftc8inx 12673 1 At at IN cord-010092-uftc8inx 12673 2 our -PRON- PRP$ cord-010092-uftc8inx 12673 3 institution institution NN cord-010092-uftc8inx 12673 4 , , , cord-010092-uftc8inx 12673 5 a a DT cord-010092-uftc8inx 12673 6 standardized standardized JJ cord-010092-uftc8inx 12673 7 approach approach NN cord-010092-uftc8inx 12673 8 for for IN cord-010092-uftc8inx 12673 9 the the DT cord-010092-uftc8inx 12673 10 use use NN cord-010092-uftc8inx 12673 11 of of IN cord-010092-uftc8inx 12673 12 therapeutic therapeutic JJ cord-010092-uftc8inx 12673 13 plasma plasma NN cord-010092-uftc8inx 12673 14 exchange exchange NN cord-010092-uftc8inx 12673 15 as as IN cord-010092-uftc8inx 12673 16 a a DT cord-010092-uftc8inx 12673 17 supportive supportive JJ cord-010092-uftc8inx 12673 18 intervention intervention NN cord-010092-uftc8inx 12673 19 for for IN cord-010092-uftc8inx 12673 20 ABO ABO NNP cord-010092-uftc8inx 12673 21 - - HYPH cord-010092-uftc8inx 12673 22 compatible compatible JJ cord-010092-uftc8inx 12673 23 immune immune JJ cord-010092-uftc8inx 12673 24 mediated mediate VBN cord-010092-uftc8inx 12673 25 rejection rejection NN cord-010092-uftc8inx 12673 26 , , , cord-010092-uftc8inx 12673 27 regardless regardless RB cord-010092-uftc8inx 12673 28 of of IN cord-010092-uftc8inx 12673 29 the the DT cord-010092-uftc8inx 12673 30 organ organ NN cord-010092-uftc8inx 12673 31 type type NN cord-010092-uftc8inx 12673 32 , , , cord-010092-uftc8inx 12673 33 has have VBZ cord-010092-uftc8inx 12673 34 been be VBN cord-010092-uftc8inx 12673 35 in in IN cord-010092-uftc8inx 12673 36 place place NN cord-010092-uftc8inx 12673 37 since since IN cord-010092-uftc8inx 12673 38 2011 2011 CD cord-010092-uftc8inx 12673 39 . . . cord-010092-uftc8inx 12674 1 Aims aim VBZ cord-010092-uftc8inx 12674 2 : : : cord-010092-uftc8inx 12675 1 A a DT cord-010092-uftc8inx 12675 2 retrospective retrospective JJ cord-010092-uftc8inx 12675 3 review review NN cord-010092-uftc8inx 12675 4 was be VBD cord-010092-uftc8inx 12675 5 performed perform VBN cord-010092-uftc8inx 12675 6 to to TO cord-010092-uftc8inx 12675 7 evaluate evaluate VB cord-010092-uftc8inx 12675 8 our -PRON- PRP$ cord-010092-uftc8inx 12675 9 patient patient NN cord-010092-uftc8inx 12675 10 outcomes outcome NNS cord-010092-uftc8inx 12675 11 using use VBG cord-010092-uftc8inx 12675 12 therapeutic therapeutic JJ cord-010092-uftc8inx 12675 13 plasma plasma NN cord-010092-uftc8inx 12675 14 exchange exchange NN cord-010092-uftc8inx 12675 15 for for IN cord-010092-uftc8inx 12675 16 the the DT cord-010092-uftc8inx 12675 17 treatment treatment NN cord-010092-uftc8inx 12675 18 of of IN cord-010092-uftc8inx 12675 19 antibody antibody NN cord-010092-uftc8inx 12675 20 mediated mediate VBN cord-010092-uftc8inx 12675 21 allograft allograft NN cord-010092-uftc8inx 12675 22 rejection rejection NN cord-010092-uftc8inx 12675 23 in in IN cord-010092-uftc8inx 12675 24 ABO ABO NNP cord-010092-uftc8inx 12675 25 - - HYPH cord-010092-uftc8inx 12675 26 compatible compatible JJ cord-010092-uftc8inx 12675 27 solid solid JJ cord-010092-uftc8inx 12675 28 organ organ NN cord-010092-uftc8inx 12675 29 transplantation transplantation NN cord-010092-uftc8inx 12675 30 . . . cord-010092-uftc8inx 12676 1 Methods method NNS cord-010092-uftc8inx 12676 2 : : : cord-010092-uftc8inx 12676 3 Patients patient NNS cord-010092-uftc8inx 12676 4 used use VBN cord-010092-uftc8inx 12676 5 for for IN cord-010092-uftc8inx 12676 6 the the DT cord-010092-uftc8inx 12676 7 retrospective retrospective JJ cord-010092-uftc8inx 12676 8 review review NN cord-010092-uftc8inx 12676 9 were be VBD cord-010092-uftc8inx 12676 10 selected select VBN cord-010092-uftc8inx 12676 11 from from IN cord-010092-uftc8inx 12676 12 an an DT cord-010092-uftc8inx 12676 13 existing exist VBG cord-010092-uftc8inx 12676 14 therapeutic therapeutic JJ cord-010092-uftc8inx 12676 15 apheresis apheresis NN cord-010092-uftc8inx 12676 16 list list NN cord-010092-uftc8inx 12676 17 . . . cord-010092-uftc8inx 12677 1 The the DT cord-010092-uftc8inx 12677 2 therapeutic therapeutic JJ cord-010092-uftc8inx 12677 3 plasma plasma NN cord-010092-uftc8inx 12677 4 exchange exchange NN cord-010092-uftc8inx 12677 5 protocol protocol NN cord-010092-uftc8inx 12677 6 consists consist VBZ cord-010092-uftc8inx 12677 7 of of IN cord-010092-uftc8inx 12677 8 : : : cord-010092-uftc8inx 12677 9 adjustment adjustment NN cord-010092-uftc8inx 12677 10 of of IN cord-010092-uftc8inx 12677 11 the the DT cord-010092-uftc8inx 12677 12 immunosuppressive immunosuppressive JJ cord-010092-uftc8inx 12677 13 medications medication NNS cord-010092-uftc8inx 12677 14 , , , cord-010092-uftc8inx 12677 15 IVIG IVIG NNP cord-010092-uftc8inx 12677 16 infusion infusion NN cord-010092-uftc8inx 12677 17 , , , cord-010092-uftc8inx 12677 18 antibody antibody NN cord-010092-uftc8inx 12677 19 removal removal NN cord-010092-uftc8inx 12677 20 by by IN cord-010092-uftc8inx 12677 21 therapeutic therapeutic JJ cord-010092-uftc8inx 12677 22 plasma plasma NN cord-010092-uftc8inx 12677 23 exchange exchange NN cord-010092-uftc8inx 12677 24 , , , cord-010092-uftc8inx 12677 25 and/or and/or CC cord-010092-uftc8inx 12677 26 the the DT cord-010092-uftc8inx 12677 27 use use NN cord-010092-uftc8inx 12677 28 of of IN cord-010092-uftc8inx 12677 29 target target NN cord-010092-uftc8inx 12677 30 - - HYPH cord-010092-uftc8inx 12677 31 specific specific JJ cord-010092-uftc8inx 12677 32 monoclonal monoclonal JJ cord-010092-uftc8inx 12677 33 antibody antibody NN cord-010092-uftc8inx 12677 34 medications medication NNS cord-010092-uftc8inx 12677 35 to to IN cord-010092-uftc8inx 12677 36 lymphocytes lymphocyte NNS cord-010092-uftc8inx 12677 37 , , , cord-010092-uftc8inx 12677 38 plasma plasma NN cord-010092-uftc8inx 12677 39 cells cell NNS cord-010092-uftc8inx 12677 40 , , , cord-010092-uftc8inx 12677 41 and/or and/or CC cord-010092-uftc8inx 12677 42 complement complement VB cord-010092-uftc8inx 12677 43 . . . cord-010092-uftc8inx 12678 1 It -PRON- PRP cord-010092-uftc8inx 12678 2 is be VBZ cord-010092-uftc8inx 12678 3 performed perform VBN cord-010092-uftc8inx 12678 4 as as IN cord-010092-uftc8inx 12678 5 follows follow VBZ cord-010092-uftc8inx 12678 6 : : : cord-010092-uftc8inx 12679 1 One one CD cord-010092-uftc8inx 12679 2 plasma plasma NN cord-010092-uftc8inx 12679 3 volume volume NN cord-010092-uftc8inx 12679 4 exchange exchange NN cord-010092-uftc8inx 12679 5 is be VBZ cord-010092-uftc8inx 12679 6 performed perform VBN cord-010092-uftc8inx 12679 7 on on IN cord-010092-uftc8inx 12679 8 days day NNS cord-010092-uftc8inx 12679 9 1 1 CD cord-010092-uftc8inx 12679 10 , , , cord-010092-uftc8inx 12679 11 2 2 CD cord-010092-uftc8inx 12679 12 , , , cord-010092-uftc8inx 12679 13 3 3 CD cord-010092-uftc8inx 12679 14 , , , cord-010092-uftc8inx 12679 15 5 5 CD cord-010092-uftc8inx 12679 16 , , , cord-010092-uftc8inx 12679 17 7 7 CD cord-010092-uftc8inx 12679 18 , , , cord-010092-uftc8inx 12679 19 9 9 CD cord-010092-uftc8inx 12679 20 along along RB cord-010092-uftc8inx 12679 21 with with IN cord-010092-uftc8inx 12679 22 one one CD cord-010092-uftc8inx 12679 23 or or CC cord-010092-uftc8inx 12679 24 more more JJR cord-010092-uftc8inx 12679 25 of of IN cord-010092-uftc8inx 12679 26 the the DT cord-010092-uftc8inx 12679 27 above above JJ cord-010092-uftc8inx 12679 28 strategies strategy NNS cord-010092-uftc8inx 12679 29 followed follow VBN cord-010092-uftc8inx 12679 30 by by IN cord-010092-uftc8inx 12679 31 an an DT cord-010092-uftc8inx 12679 32 IVIG IVIG NNP cord-010092-uftc8inx 12679 33 infusion infusion NN cord-010092-uftc8inx 12679 34 . . . cord-010092-uftc8inx 12680 1 Cases case NNS cord-010092-uftc8inx 12680 2 with with IN cord-010092-uftc8inx 12680 3 allograft allograft NN cord-010092-uftc8inx 12680 4 rejection rejection NN cord-010092-uftc8inx 12680 5 in in IN cord-010092-uftc8inx 12680 6 which which WDT cord-010092-uftc8inx 12680 7 plasmapheresis plasmapheresis NN cord-010092-uftc8inx 12680 8 was be VBD cord-010092-uftc8inx 12680 9 not not RB cord-010092-uftc8inx 12680 10 used use VBN cord-010092-uftc8inx 12680 11 were be VBD cord-010092-uftc8inx 12680 12 excluded exclude VBN cord-010092-uftc8inx 12680 13 . . . cord-010092-uftc8inx 12681 1 and and CC cord-010092-uftc8inx 12681 2 T T NNP cord-010092-uftc8inx 12681 3 Devos Devos NNP cord-010092-uftc8inx 12681 4 7 7 CD cord-010092-uftc8inx 12681 5 Aims Aims NNPS cord-010092-uftc8inx 12681 6 : : : cord-010092-uftc8inx 12682 1 This this DT cord-010092-uftc8inx 12682 2 study study NN cord-010092-uftc8inx 12682 3 aimed aim VBD cord-010092-uftc8inx 12682 4 to to TO cord-010092-uftc8inx 12682 5 explore explore VB cord-010092-uftc8inx 12682 6 the the DT cord-010092-uftc8inx 12682 7 possible possible JJ cord-010092-uftc8inx 12682 8 causes cause NNS cord-010092-uftc8inx 12682 9 of of IN cord-010092-uftc8inx 12682 10 the the DT cord-010092-uftc8inx 12682 11 decreased decrease VBN cord-010092-uftc8inx 12682 12 transfusion transfusion NN cord-010092-uftc8inx 12682 13 rate rate NN cord-010092-uftc8inx 12682 14 for for IN cord-010092-uftc8inx 12682 15 all all DT cord-010092-uftc8inx 12682 16 adult adult NN cord-010092-uftc8inx 12682 17 cardiac cardiac JJ cord-010092-uftc8inx 12682 18 surgery surgery NN cord-010092-uftc8inx 12682 19 patients patient NNS cord-010092-uftc8inx 12682 20 . . . cord-010092-uftc8inx 12683 1 Methods method NNS cord-010092-uftc8inx 12683 2 : : : cord-010092-uftc8inx 12684 1 Data datum NNS cord-010092-uftc8inx 12684 2 were be VBD cord-010092-uftc8inx 12684 3 collected collect VBN cord-010092-uftc8inx 12684 4 from from IN cord-010092-uftc8inx 12684 5 adult adult NN cord-010092-uftc8inx 12684 6 cardiac cardiac JJ cord-010092-uftc8inx 12684 7 surgery surgery NN cord-010092-uftc8inx 12684 8 patients patient NNS cord-010092-uftc8inx 12684 9 during during IN cord-010092-uftc8inx 12684 10 the the DT cord-010092-uftc8inx 12684 11 mentioned mention VBN cord-010092-uftc8inx 12684 12 time time NN cord-010092-uftc8inx 12684 13 frame frame NN cord-010092-uftc8inx 12684 14 and and CC cord-010092-uftc8inx 12684 15 were be VBD cord-010092-uftc8inx 12684 16 extracted extract VBN cord-010092-uftc8inx 12684 17 from from IN cord-010092-uftc8inx 12684 18 electronic electronic JJ cord-010092-uftc8inx 12684 19 patient patient NN cord-010092-uftc8inx 12684 20 files file NNS cord-010092-uftc8inx 12684 21 and and CC cord-010092-uftc8inx 12684 22 a a DT cord-010092-uftc8inx 12684 23 database database NN cord-010092-uftc8inx 12684 24 of of IN cord-010092-uftc8inx 12684 25 the the DT cord-010092-uftc8inx 12684 26 Department Department NNP cord-010092-uftc8inx 12684 27 of of IN cord-010092-uftc8inx 12684 28 Cardiac Cardiac NNP cord-010092-uftc8inx 12684 29 Surgery Surgery NNP cord-010092-uftc8inx 12684 30 . . . cord-010092-uftc8inx 12685 1 A a DT cord-010092-uftc8inx 12685 2 set set NN cord-010092-uftc8inx 12685 3 of of IN cord-010092-uftc8inx 12685 4 63 63 CD cord-010092-uftc8inx 12685 5 variables variable NNS cord-010092-uftc8inx 12685 6 was be VBD cord-010092-uftc8inx 12685 7 defined define VBN cord-010092-uftc8inx 12685 8 as as IN cord-010092-uftc8inx 12685 9 possible possible JJ cord-010092-uftc8inx 12685 10 confounders confounder NNS cord-010092-uftc8inx 12685 11 by by IN cord-010092-uftc8inx 12685 12 a a DT cord-010092-uftc8inx 12685 13 panel panel NN cord-010092-uftc8inx 12685 14 of of IN cord-010092-uftc8inx 12685 15 experts expert NNS cord-010092-uftc8inx 12685 16 . . . cord-010092-uftc8inx 12686 1 After after IN cord-010092-uftc8inx 12686 2 discussion discussion NN cord-010092-uftc8inx 12686 3 , , , cord-010092-uftc8inx 12686 4 9 9 CD cord-010092-uftc8inx 12686 5 global global JJ cord-010092-uftc8inx 12686 6 variables variable NNS cord-010092-uftc8inx 12686 7 ( ( -LRB- cord-010092-uftc8inx 12686 8 age age NN cord-010092-uftc8inx 12686 9 , , , cord-010092-uftc8inx 12686 10 gender gender NN cord-010092-uftc8inx 12686 11 , , , cord-010092-uftc8inx 12686 12 duration duration NN cord-010092-uftc8inx 12686 13 of of IN cord-010092-uftc8inx 12686 14 surgery surgery NN cord-010092-uftc8inx 12686 15 , , , cord-010092-uftc8inx 12686 16 use use NN cord-010092-uftc8inx 12686 17 of of IN cord-010092-uftc8inx 12686 18 CPB CPB NNP cord-010092-uftc8inx 12686 19 ( ( -LRB- cord-010092-uftc8inx 12686 20 cardio cardio JJ cord-010092-uftc8inx 12686 21 - - HYPH cord-010092-uftc8inx 12686 22 pulmonary pulmonary JJ cord-010092-uftc8inx 12686 23 bypass bypass NN cord-010092-uftc8inx 12686 24 ) ) -RRB- cord-010092-uftc8inx 12686 25 , , , cord-010092-uftc8inx 12686 26 American American NNP cord-010092-uftc8inx 12686 27 Society Society NNP cord-010092-uftc8inx 12686 28 of of IN cord-010092-uftc8inx 12686 29 Anesthesiologists Anesthesiologists NNPS cord-010092-uftc8inx 12686 30 ( ( -LRB- cord-010092-uftc8inx 12686 31 ASA ASA NNP cord-010092-uftc8inx 12686 32 ) ) -RRB- cord-010092-uftc8inx 12686 33 risk risk NN cord-010092-uftc8inx 12686 34 score score NN cord-010092-uftc8inx 12686 35 , , , cord-010092-uftc8inx 12686 36 type type NN cord-010092-uftc8inx 12686 37 of of IN cord-010092-uftc8inx 12686 38 surgery surgery NN cord-010092-uftc8inx 12686 39 , , , cord-010092-uftc8inx 12686 40 urgency urgency NN cord-010092-uftc8inx 12686 41 , , , cord-010092-uftc8inx 12686 42 attending attend VBG cord-010092-uftc8inx 12686 43 cardiac cardiac JJ cord-010092-uftc8inx 12686 44 surgeon surgeon NN cord-010092-uftc8inx 12686 45 and and CC cord-010092-uftc8inx 12686 46 attending attend VBG cord-010092-uftc8inx 12686 47 anesthesiologist anesthesiologist NN cord-010092-uftc8inx 12686 48 ) ) -RRB- cord-010092-uftc8inx 12686 49 and and CC cord-010092-uftc8inx 12686 50 7 7 CD cord-010092-uftc8inx 12686 51 CPB CPB NNP cord-010092-uftc8inx 12686 52 - - HYPH cord-010092-uftc8inx 12686 53 related relate VBN cord-010092-uftc8inx 12686 54 variables variable NNS cord-010092-uftc8inx 12686 55 ( ( -LRB- cord-010092-uftc8inx 12686 56 administration administration NN cord-010092-uftc8inx 12686 57 of of IN cord-010092-uftc8inx 12686 58 cardioplegia cardioplegia NNP cord-010092-uftc8inx 12687 1 Yes yes UH cord-010092-uftc8inx 12687 2 / / , cord-010092-uftc8inx 12687 3 No no UH cord-010092-uftc8inx 12687 4 ( ( -LRB- cord-010092-uftc8inx 12687 5 CPG CPG NNP cord-010092-uftc8inx 12687 6 ) ) -RRB- cord-010092-uftc8inx 12687 7 , , , cord-010092-uftc8inx 12687 8 duration duration NN cord-010092-uftc8inx 12687 9 of of IN cord-010092-uftc8inx 12687 10 CPB CPB NNP cord-010092-uftc8inx 12687 11 , , , cord-010092-uftc8inx 12687 12 circulatory circulatory JJ cord-010092-uftc8inx 12687 13 arrest arrest NN cord-010092-uftc8inx 12687 14 , , , cord-010092-uftc8inx 12687 15 hypothermia hypothermia NN cord-010092-uftc8inx 12687 16 , , , cord-010092-uftc8inx 12687 17 duration duration NN cord-010092-uftc8inx 12687 18 of of IN cord-010092-uftc8inx 12687 19 aortic aortic JJ cord-010092-uftc8inx 12687 20 cross cross JJ cord-010092-uftc8inx 12687 21 - - NN cord-010092-uftc8inx 12687 22 clamp clamp JJ cord-010092-uftc8inx 12687 23 , , , cord-010092-uftc8inx 12687 24 baseline baseline JJ cord-010092-uftc8inx 12687 25 hemoglobin hemoglobin NN cord-010092-uftc8inx 12687 26 and and CC cord-010092-uftc8inx 12687 27 CPB CPB NNP cord-010092-uftc8inx 12687 28 - - HYPH cord-010092-uftc8inx 12687 29 priming prime VBG cord-010092-uftc8inx 12687 30 volume volume NN cord-010092-uftc8inx 12687 31 ) ) -RRB- cord-010092-uftc8inx 12687 32 were be VBD cord-010092-uftc8inx 12687 33 retained retain VBN cord-010092-uftc8inx 12687 34 . . . cord-010092-uftc8inx 12688 1 Negative negative JJ cord-010092-uftc8inx 12688 2 binomial binomial NN cord-010092-uftc8inx 12688 3 models model NNS cord-010092-uftc8inx 12688 4 for for IN cord-010092-uftc8inx 12688 5 counts count NNS cord-010092-uftc8inx 12688 6 were be VBD cord-010092-uftc8inx 12688 7 used use VBN cord-010092-uftc8inx 12688 8 for for IN cord-010092-uftc8inx 12688 9 data datum NNS cord-010092-uftc8inx 12688 10 analysis analysis NN cord-010092-uftc8inx 12688 11 . . . cord-010092-uftc8inx 12689 1 All all DT cord-010092-uftc8inx 12689 2 analyses analysis NNS cord-010092-uftc8inx 12689 3 were be VBD cord-010092-uftc8inx 12689 4 performed perform VBN cord-010092-uftc8inx 12689 5 with with IN cord-010092-uftc8inx 12689 6 SPSS SPSS NNP cord-010092-uftc8inx 12689 7 . . . cord-010092-uftc8inx 12690 1 Results result NNS cord-010092-uftc8inx 12690 2 : : : cord-010092-uftc8inx 12691 1 1018 1018 CD cord-010092-uftc8inx 12691 2 patients patient NNS cord-010092-uftc8inx 12691 3 were be VBD cord-010092-uftc8inx 12691 4 extracted extract VBN cord-010092-uftc8inx 12691 5 from from IN cord-010092-uftc8inx 12691 6 databases database NNS cord-010092-uftc8inx 12691 7 and and CC cord-010092-uftc8inx 12691 8 further further RB cord-010092-uftc8inx 12691 9 analyzed analyze VBN cord-010092-uftc8inx 12691 10 . . . cord-010092-uftc8inx 12692 1 The the DT cord-010092-uftc8inx 12692 2 mean mean JJ cord-010092-uftc8inx 12692 3 age age NN cord-010092-uftc8inx 12692 4 of of IN cord-010092-uftc8inx 12692 5 this this DT cord-010092-uftc8inx 12692 6 group group NN cord-010092-uftc8inx 12692 7 was be VBD cord-010092-uftc8inx 12692 8 65,9 65,9 CD cord-010092-uftc8inx 12692 9 years year NNS cord-010092-uftc8inx 12693 1 ( ( -LRB- cord-010092-uftc8inx 12693 2 SD sd NN cord-010092-uftc8inx 12693 3 + + CC cord-010092-uftc8inx 12693 4 /-14,1 /-14,1 . cord-010092-uftc8inx 12693 5 years year NNS cord-010092-uftc8inx 12693 6 ) ) -RRB- cord-010092-uftc8inx 12693 7 and and CC cord-010092-uftc8inx 12693 8 67.3 67.3 CD cord-010092-uftc8inx 12693 9 % % NN cord-010092-uftc8inx 12693 10 of of IN cord-010092-uftc8inx 12693 11 them -PRON- PRP cord-010092-uftc8inx 12693 12 were be VBD cord-010092-uftc8inx 12693 13 male male JJ cord-010092-uftc8inx 12693 14 . . . cord-010092-uftc8inx 12694 1 The the DT cord-010092-uftc8inx 12694 2 mean mean JJ cord-010092-uftc8inx 12694 3 duration duration NN cord-010092-uftc8inx 12694 4 of of IN cord-010092-uftc8inx 12694 5 surgery surgery NN cord-010092-uftc8inx 12694 6 was be VBD cord-010092-uftc8inx 12694 7 256 256 CD cord-010092-uftc8inx 12694 8 min min NN cord-010092-uftc8inx 12694 9 ( ( -LRB- cord-010092-uftc8inx 12694 10 SD sd NN cord-010092-uftc8inx 12694 11 + + CC cord-010092-uftc8inx 12694 12 /-88,3 /-88,3 . cord-010092-uftc8inx 12694 13 min min NNP cord-010092-uftc8inx 12694 14 ) ) -RRB- cord-010092-uftc8inx 12694 15 . . . cord-010092-uftc8inx 12695 1 The the DT cord-010092-uftc8inx 12695 2 decrease decrease NN cord-010092-uftc8inx 12695 3 of of IN cord-010092-uftc8inx 12695 4 perioperative perioperative JJ cord-010092-uftc8inx 12695 5 RBC RBC NNP cord-010092-uftc8inx 12695 6 transfusion transfusion NN cord-010092-uftc8inx 12695 7 rate rate NN cord-010092-uftc8inx 12695 8 over over IN cord-010092-uftc8inx 12695 9 four four CD cord-010092-uftc8inx 12695 10 years year NNS cord-010092-uftc8inx 12695 11 was be VBD cord-010092-uftc8inx 12695 12 statistically statistically RB cord-010092-uftc8inx 12695 13 significant significant JJ cord-010092-uftc8inx 12695 14 ( ( -LRB- cord-010092-uftc8inx 12695 15 P p NN cord-010092-uftc8inx 12695 16 < < XX cord-010092-uftc8inx 12695 17 0.001 0.001 CD cord-010092-uftc8inx 12695 18 ) ) -RRB- cord-010092-uftc8inx 12695 19 . . . cord-010092-uftc8inx 12696 1 In in IN cord-010092-uftc8inx 12696 2 2011 2011 CD cord-010092-uftc8inx 12696 3 , , , cord-010092-uftc8inx 12696 4 the the DT cord-010092-uftc8inx 12696 5 mean mean JJ cord-010092-uftc8inx 12696 6 use use NN cord-010092-uftc8inx 12696 7 was be VBD cord-010092-uftc8inx 12696 8 2,34 2,34 CD cord-010092-uftc8inx 12696 9 units unit NNS cord-010092-uftc8inx 12696 10 per per IN cord-010092-uftc8inx 12696 11 operation operation NN cord-010092-uftc8inx 12696 12 ( ( -LRB- cord-010092-uftc8inx 12696 13 SD sd NN cord-010092-uftc8inx 12696 14 + + CC cord-010092-uftc8inx 12696 15 /-2,277 /-2,277 NN cord-010092-uftc8inx 12696 16 ) ) -RRB- cord-010092-uftc8inx 12696 17 , , , cord-010092-uftc8inx 12696 18 which which WDT cord-010092-uftc8inx 12696 19 changed change VBD cord-010092-uftc8inx 12696 20 to to IN cord-010092-uftc8inx 12696 21 1,38 1,38 CD cord-010092-uftc8inx 12696 22 units unit NNS cord-010092-uftc8inx 12696 23 ( ( -LRB- cord-010092-uftc8inx 12696 24 SD sd NN cord-010092-uftc8inx 12696 25 + + CC cord-010092-uftc8inx 12696 26 /-2,158 /-2,158 NN cord-010092-uftc8inx 12696 27 ) ) -RRB- cord-010092-uftc8inx 12696 28 in in IN cord-010092-uftc8inx 12696 29 2014 2014 CD cord-010092-uftc8inx 12696 30 . . . cord-010092-uftc8inx 12697 1 Three three CD cord-010092-uftc8inx 12697 2 variables variable NNS cord-010092-uftc8inx 12697 3 ( ( -LRB- cord-010092-uftc8inx 12697 4 urgency urgency NN cord-010092-uftc8inx 12697 5 , , , cord-010092-uftc8inx 12697 6 attending attend VBG cord-010092-uftc8inx 12697 7 cardiac cardiac JJ cord-010092-uftc8inx 12697 8 surgeon surgeon NN cord-010092-uftc8inx 12697 9 , , , cord-010092-uftc8inx 12697 10 attending attend VBG cord-010092-uftc8inx 12697 11 anesthesiologist anesthesiologist NN cord-010092-uftc8inx 12697 12 ) ) -RRB- cord-010092-uftc8inx 12697 13 changed change VBN cord-010092-uftc8inx 12697 14 significantly significantly RB cord-010092-uftc8inx 12697 15 over over IN cord-010092-uftc8inx 12697 16 4 4 CD cord-010092-uftc8inx 12697 17 years year NNS cord-010092-uftc8inx 12697 18 and and CC cord-010092-uftc8inx 12697 19 were be VBD cord-010092-uftc8inx 12697 20 used use VBN cord-010092-uftc8inx 12697 21 in in IN cord-010092-uftc8inx 12697 22 a a DT cord-010092-uftc8inx 12697 23 multivariable multivariable JJ cord-010092-uftc8inx 12697 24 model model NN cord-010092-uftc8inx 12697 25 as as IN cord-010092-uftc8inx 12697 26 confounders confounder NNS cord-010092-uftc8inx 12697 27 together together RB cord-010092-uftc8inx 12697 28 with with IN cord-010092-uftc8inx 12697 29 RBC RBC NNP cord-010092-uftc8inx 12697 30 transfusions transfusion NNS cord-010092-uftc8inx 12697 31 and and CC cord-010092-uftc8inx 12697 32 year year NN cord-010092-uftc8inx 12697 33 . . . cord-010092-uftc8inx 12698 1 Even even RB cord-010092-uftc8inx 12698 2 after after IN cord-010092-uftc8inx 12698 3 adjustment adjustment NN cord-010092-uftc8inx 12698 4 for for IN cord-010092-uftc8inx 12698 5 these these DT cord-010092-uftc8inx 12698 6 factors factor NNS cord-010092-uftc8inx 12698 7 , , , cord-010092-uftc8inx 12698 8 the the DT cord-010092-uftc8inx 12698 9 decrease decrease NN cord-010092-uftc8inx 12698 10 in in IN cord-010092-uftc8inx 12698 11 RBC RBC NNP cord-010092-uftc8inx 12698 12 transfusion transfusion NN cord-010092-uftc8inx 12698 13 rate rate NN cord-010092-uftc8inx 12698 14 was be VBD cord-010092-uftc8inx 12698 15 still still RB cord-010092-uftc8inx 12698 16 statistically statistically RB cord-010092-uftc8inx 12698 17 significant significant JJ cord-010092-uftc8inx 12698 18 ( ( -LRB- cord-010092-uftc8inx 12698 19 P p NN cord-010092-uftc8inx 12698 20 < < XX cord-010092-uftc8inx 12698 21 0.001 0.001 CD cord-010092-uftc8inx 12698 22 ) ) -RRB- cord-010092-uftc8inx 12698 23 . . . cord-010092-uftc8inx 12699 1 In in IN cord-010092-uftc8inx 12699 2 the the DT cord-010092-uftc8inx 12699 3 specific specific JJ cord-010092-uftc8inx 12699 4 group group NN cord-010092-uftc8inx 12699 5 of of IN cord-010092-uftc8inx 12699 6 patients patient NNS cord-010092-uftc8inx 12699 7 undergoing undergo VBG cord-010092-uftc8inx 12699 8 cardiac cardiac JJ cord-010092-uftc8inx 12699 9 surgery surgery NN cord-010092-uftc8inx 12699 10 with with IN cord-010092-uftc8inx 12699 11 CPB CPB NNP cord-010092-uftc8inx 12699 12 ( ( -LRB- cord-010092-uftc8inx 12699 13 n n NN cord-010092-uftc8inx 12699 14 = = SYM cord-010092-uftc8inx 12699 15 640 640 CD cord-010092-uftc8inx 12699 16 ) ) -RRB- cord-010092-uftc8inx 12699 17 , , , cord-010092-uftc8inx 12699 18 the the DT cord-010092-uftc8inx 12699 19 use use NN cord-010092-uftc8inx 12699 20 of of IN cord-010092-uftc8inx 12699 21 RBC RBC NNP cord-010092-uftc8inx 12699 22 was be VBD cord-010092-uftc8inx 12699 23 also also RB cord-010092-uftc8inx 12699 24 significantly significantly RB cord-010092-uftc8inx 12699 25 reduced reduce VBN cord-010092-uftc8inx 12699 26 ( ( -LRB- cord-010092-uftc8inx 12699 27 P p NN cord-010092-uftc8inx 12699 28 < < XX cord-010092-uftc8inx 12699 29 0.001 0.001 CD cord-010092-uftc8inx 12699 30 ) ) -RRB- cord-010092-uftc8inx 12699 31 . . . cord-010092-uftc8inx 12700 1 In in IN cord-010092-uftc8inx 12700 2 2011 2011 CD cord-010092-uftc8inx 12700 3 , , , cord-010092-uftc8inx 12700 4 the the DT cord-010092-uftc8inx 12700 5 mean mean JJ cord-010092-uftc8inx 12700 6 use use NN cord-010092-uftc8inx 12700 7 was be VBD cord-010092-uftc8inx 12700 8 3,06 3,06 CD cord-010092-uftc8inx 12700 9 units unit NNS cord-010092-uftc8inx 12700 10 per per IN cord-010092-uftc8inx 12700 11 operation operation NN cord-010092-uftc8inx 12700 12 ( ( -LRB- cord-010092-uftc8inx 12700 13 SD sd NN cord-010092-uftc8inx 12700 14 + + SYM cord-010092-uftc8inx 12700 15 /-0,448 /-0,448 NNS cord-010092-uftc8inx 12700 16 ) ) -RRB- cord-010092-uftc8inx 12700 17 and and CC cord-010092-uftc8inx 12700 18 this this DT cord-010092-uftc8inx 12700 19 changed change VBD cord-010092-uftc8inx 12700 20 to to IN cord-010092-uftc8inx 12700 21 1,94 1,94 CD cord-010092-uftc8inx 12700 22 units unit NNS cord-010092-uftc8inx 12700 23 ( ( -LRB- cord-010092-uftc8inx 12700 24 SD sd NN cord-010092-uftc8inx 12701 1 + + CC cord-010092-uftc8inx 12701 2 /-0,167 /-0,167 . cord-010092-uftc8inx 12701 3 ) ) -RRB- cord-010092-uftc8inx 12701 4 in in IN cord-010092-uftc8inx 12701 5 2014 2014 CD cord-010092-uftc8inx 12701 6 . . . cord-010092-uftc8inx 12702 1 After after IN cord-010092-uftc8inx 12702 2 correction correction NN cord-010092-uftc8inx 12702 3 for for IN cord-010092-uftc8inx 12702 4 the the DT cord-010092-uftc8inx 12702 5 3 3 CD cord-010092-uftc8inx 12702 6 CPB CPB NNP cord-010092-uftc8inx 12702 7 variables variable NNS cord-010092-uftc8inx 12702 8 that that WDT cord-010092-uftc8inx 12702 9 notably notably RB cord-010092-uftc8inx 12702 10 changed change VBD cord-010092-uftc8inx 12702 11 over over IN cord-010092-uftc8inx 12702 12 the the DT cord-010092-uftc8inx 12702 13 4 4 CD cord-010092-uftc8inx 12702 14 years year NNS cord-010092-uftc8inx 12702 15 ( ( -LRB- cord-010092-uftc8inx 12702 16 CPG CPG NNP cord-010092-uftc8inx 12702 17 , , , cord-010092-uftc8inx 12702 18 priming prime VBG cord-010092-uftc8inx 12702 19 volume volume NN cord-010092-uftc8inx 12702 20 and and CC cord-010092-uftc8inx 12702 21 hypothermia hypothermia NN cord-010092-uftc8inx 12702 22 ) ) -RRB- cord-010092-uftc8inx 12702 23 and and CC cord-010092-uftc8inx 12702 24 the the DT cord-010092-uftc8inx 12702 25 three three CD cord-010092-uftc8inx 12702 26 previously previously RB cord-010092-uftc8inx 12702 27 defined define VBN cord-010092-uftc8inx 12702 28 confounders confounder NNS cord-010092-uftc8inx 12702 29 ( ( -LRB- cord-010092-uftc8inx 12702 30 urgency urgency NN cord-010092-uftc8inx 12702 31 , , , cord-010092-uftc8inx 12702 32 attending attend VBG cord-010092-uftc8inx 12702 33 cardiac cardiac JJ cord-010092-uftc8inx 12702 34 surgeon surgeon NN cord-010092-uftc8inx 12702 35 and and CC cord-010092-uftc8inx 12702 36 attending attend VBG cord-010092-uftc8inx 12702 37 anesthesiologist anesthesiologist NN cord-010092-uftc8inx 12702 38 ) ) -RRB- cord-010092-uftc8inx 12703 1 the the DT cord-010092-uftc8inx 12703 2 reduction reduction NN cord-010092-uftc8inx 12703 3 of of IN cord-010092-uftc8inx 12703 4 RBC RBC NNP cord-010092-uftc8inx 12703 5 transfusions transfusion NNS cord-010092-uftc8inx 12703 6 over over IN cord-010092-uftc8inx 12703 7 4 4 CD cord-010092-uftc8inx 12703 8 years year NNS cord-010092-uftc8inx 12703 9 still still RB cord-010092-uftc8inx 12703 10 remained remain VBD cord-010092-uftc8inx 12703 11 statistically statistically RB cord-010092-uftc8inx 12703 12 significant significant JJ cord-010092-uftc8inx 12703 13 ( ( -LRB- cord-010092-uftc8inx 12703 14 P p NN cord-010092-uftc8inx 12703 15 < < XX cord-010092-uftc8inx 12703 16 0.001 0.001 CD cord-010092-uftc8inx 12703 17 ) ) -RRB- cord-010092-uftc8inx 12703 18 . . . cord-010092-uftc8inx 12704 1 Summary Summary NNP cord-010092-uftc8inx 12704 2 / / SYM cord-010092-uftc8inx 12704 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 12704 4 : : : cord-010092-uftc8inx 12705 1 Our -PRON- PRP$ cord-010092-uftc8inx 12705 2 study study NN cord-010092-uftc8inx 12705 3 shows show VBZ cord-010092-uftc8inx 12705 4 evidence evidence NN cord-010092-uftc8inx 12705 5 for for IN cord-010092-uftc8inx 12705 6 a a DT cord-010092-uftc8inx 12705 7 decreased decrease VBN cord-010092-uftc8inx 12705 8 RBC RBC NNP cord-010092-uftc8inx 12705 9 transfusion transfusion NN cord-010092-uftc8inx 12705 10 rate rate NN cord-010092-uftc8inx 12705 11 in in IN cord-010092-uftc8inx 12705 12 adult adult NN cord-010092-uftc8inx 12705 13 patients patient NNS cord-010092-uftc8inx 12705 14 undergoing undergo VBG cord-010092-uftc8inx 12705 15 cardiac cardiac JJ cord-010092-uftc8inx 12705 16 surgery surgery NN cord-010092-uftc8inx 12705 17 between between IN cord-010092-uftc8inx 12705 18 2011 2011 CD cord-010092-uftc8inx 12705 19 and and CC cord-010092-uftc8inx 12705 20 2014 2014 CD cord-010092-uftc8inx 12705 21 . . . cord-010092-uftc8inx 12706 1 This this DT cord-010092-uftc8inx 12706 2 tendency tendency NN cord-010092-uftc8inx 12706 3 was be VBD cord-010092-uftc8inx 12706 4 also also RB cord-010092-uftc8inx 12706 5 seen see VBN cord-010092-uftc8inx 12706 6 in in IN cord-010092-uftc8inx 12706 7 the the DT cord-010092-uftc8inx 12706 8 subgroup subgroup NN cord-010092-uftc8inx 12706 9 of of IN cord-010092-uftc8inx 12706 10 patients patient NNS cord-010092-uftc8inx 12706 11 undergoing undergo VBG cord-010092-uftc8inx 12706 12 surgery surgery NN cord-010092-uftc8inx 12706 13 with with IN cord-010092-uftc8inx 12706 14 CPB CPB NNP cord-010092-uftc8inx 12706 15 . . . cord-010092-uftc8inx 12707 1 Possible possible JJ cord-010092-uftc8inx 12707 2 explanations explanation NNS cord-010092-uftc8inx 12707 3 of of IN cord-010092-uftc8inx 12707 4 the the DT cord-010092-uftc8inx 12707 5 decrease decrease NN cord-010092-uftc8inx 12707 6 are be VBP cord-010092-uftc8inx 12707 7 implementation implementation NN cord-010092-uftc8inx 12707 8 of of IN cord-010092-uftc8inx 12707 9 various various JJ cord-010092-uftc8inx 12707 10 established establish VBN cord-010092-uftc8inx 12707 11 parts part NNS cord-010092-uftc8inx 12707 12 of of IN cord-010092-uftc8inx 12707 13 patient patient JJ cord-010092-uftc8inx 12707 14 blood blood NN cord-010092-uftc8inx 12707 15 management management NN cord-010092-uftc8inx 12707 16 . . . cord-010092-uftc8inx 12708 1 However however RB cord-010092-uftc8inx 12708 2 , , , cord-010092-uftc8inx 12708 3 a a DT cord-010092-uftc8inx 12708 4 unique unique JJ cord-010092-uftc8inx 12708 5 reason reason NN cord-010092-uftc8inx 12708 6 could could MD cord-010092-uftc8inx 12708 7 not not RB cord-010092-uftc8inx 12708 8 be be VB cord-010092-uftc8inx 12708 9 identified identify VBN cord-010092-uftc8inx 12708 10 in in IN cord-010092-uftc8inx 12708 11 this this DT cord-010092-uftc8inx 12708 12 study study NN cord-010092-uftc8inx 12708 13 . . . cord-010092-uftc8inx 12709 1 Background background NN cord-010092-uftc8inx 12709 2 : : : cord-010092-uftc8inx 12710 1 Growing grow VBG cord-010092-uftc8inx 12710 2 worldwide worldwide JJ cord-010092-uftc8inx 12710 3 demand demand NN cord-010092-uftc8inx 12710 4 for for IN cord-010092-uftc8inx 12710 5 immunoglobulin immunoglobulin NN cord-010092-uftc8inx 12710 6 products product NNS cord-010092-uftc8inx 12710 7 such such JJ cord-010092-uftc8inx 12710 8 as as IN cord-010092-uftc8inx 12710 9 intravenous intravenous JJ cord-010092-uftc8inx 12710 10 immunoglobulin immunoglobulin NN cord-010092-uftc8inx 12710 11 ( ( -LRB- cord-010092-uftc8inx 12710 12 IVIg IVIg NNP cord-010092-uftc8inx 12710 13 ) ) -RRB- cord-010092-uftc8inx 12710 14 and and CC cord-010092-uftc8inx 12710 15 subcutaneous subcutaneous JJ cord-010092-uftc8inx 12710 16 immunoglobulin immunoglobulin NN cord-010092-uftc8inx 12710 17 ( ( -LRB- cord-010092-uftc8inx 12710 18 SCIg SCIg NNS cord-010092-uftc8inx 12710 19 ) ) -RRB- cord-010092-uftc8inx 12710 20 is be VBZ cord-010092-uftc8inx 12710 21 driving drive VBG cord-010092-uftc8inx 12710 22 plasma plasma NN cord-010092-uftc8inx 12710 23 collection collection NN cord-010092-uftc8inx 12710 24 . . . cord-010092-uftc8inx 12711 1 Patients patient NNS cord-010092-uftc8inx 12711 2 with with IN cord-010092-uftc8inx 12711 3 primary primary JJ cord-010092-uftc8inx 12711 4 immunodeficiency immunodeficiency NN cord-010092-uftc8inx 12711 5 ( ( -LRB- cord-010092-uftc8inx 12711 6 PID PID NNP cord-010092-uftc8inx 12711 7 ) ) -RRB- cord-010092-uftc8inx 12711 8 or or CC cord-010092-uftc8inx 12711 9 secondary secondary JJ cord-010092-uftc8inx 12711 10 immunodeficiency immunodeficiency NN cord-010092-uftc8inx 12711 11 due due IN cord-010092-uftc8inx 12711 12 to to IN cord-010092-uftc8inx 12711 13 haematological haematological JJ cord-010092-uftc8inx 12711 14 malignancy malignancy NN cord-010092-uftc8inx 12711 15 or or CC cord-010092-uftc8inx 12711 16 its -PRON- PRP$ cord-010092-uftc8inx 12711 17 treatment treatment NN cord-010092-uftc8inx 12711 18 ( ( -LRB- cord-010092-uftc8inx 12711 19 SID SID NNP cord-010092-uftc8inx 12711 20 ) ) -RRB- cord-010092-uftc8inx 12711 21 rely rely VBP cord-010092-uftc8inx 12711 22 on on IN cord-010092-uftc8inx 12711 23 these these DT cord-010092-uftc8inx 12711 24 products product NNS cord-010092-uftc8inx 12711 25 to to TO cord-010092-uftc8inx 12711 26 maintain maintain VB cord-010092-uftc8inx 12711 27 therapeutic therapeutic JJ cord-010092-uftc8inx 12711 28 serum serum NN cord-010092-uftc8inx 12711 29 IgG igg NN cord-010092-uftc8inx 12711 30 levels level NNS cord-010092-uftc8inx 12711 31 to to TO cord-010092-uftc8inx 12711 32 minimise minimise VB cord-010092-uftc8inx 12711 33 recurrent recurrent JJ cord-010092-uftc8inx 12711 34 infection infection NN cord-010092-uftc8inx 12711 35 . . . cord-010092-uftc8inx 12712 1 Efficacy efficacy NN cord-010092-uftc8inx 12712 2 of of IN cord-010092-uftc8inx 12712 3 immunoglobulin immunoglobulin NN cord-010092-uftc8inx 12712 4 replacement replacement NN cord-010092-uftc8inx 12712 5 therapy therapy NN cord-010092-uftc8inx 12712 6 ( ( -LRB- cord-010092-uftc8inx 12712 7 IRT IRT NNP cord-010092-uftc8inx 12712 8 ) ) -RRB- cord-010092-uftc8inx 12712 9 in in IN cord-010092-uftc8inx 12712 10 PID PID NNP cord-010092-uftc8inx 12712 11 is be VBZ cord-010092-uftc8inx 12712 12 well well RB cord-010092-uftc8inx 12712 13 established establish VBN cord-010092-uftc8inx 12712 14 but but CC cord-010092-uftc8inx 12712 15 information information NN cord-010092-uftc8inx 12712 16 on on IN cord-010092-uftc8inx 12712 17 SID SID NNP cord-010092-uftc8inx 12712 18 is be VBZ cord-010092-uftc8inx 12712 19 limited limit VBN cord-010092-uftc8inx 12712 20 . . . cord-010092-uftc8inx 12713 1 The the DT cord-010092-uftc8inx 12713 2 different different JJ cord-010092-uftc8inx 12713 3 aetiologies aetiology NNS cord-010092-uftc8inx 12713 4 of of IN cord-010092-uftc8inx 12713 5 hypogammaglobulinaemia hypogammaglobulinaemia NN cord-010092-uftc8inx 12713 6 between between IN cord-010092-uftc8inx 12713 7 PID PID NNP cord-010092-uftc8inx 12713 8 and and CC cord-010092-uftc8inx 12713 9 SID SID NNP cord-010092-uftc8inx 12713 10 raised raise VBD cord-010092-uftc8inx 12713 11 the the DT cord-010092-uftc8inx 12713 12 question question NN cord-010092-uftc8inx 12713 13 of of IN cord-010092-uftc8inx 12713 14 whether whether IN cord-010092-uftc8inx 12713 15 SID SID NNP cord-010092-uftc8inx 12713 16 patients patient NNS cord-010092-uftc8inx 12713 17 on on IN cord-010092-uftc8inx 12713 18 IRT IRT NNP cord-010092-uftc8inx 12713 19 experience experience NN cord-010092-uftc8inx 12713 20 similar similar JJ cord-010092-uftc8inx 12713 21 clinical clinical JJ cord-010092-uftc8inx 12713 22 and and CC cord-010092-uftc8inx 12713 23 quality quality NN cord-010092-uftc8inx 12713 24 of of IN cord-010092-uftc8inx 12713 25 life life NN cord-010092-uftc8inx 12713 26 ( ( -LRB- cord-010092-uftc8inx 12713 27 QoL qol NN cord-010092-uftc8inx 12713 28 ) ) -RRB- cord-010092-uftc8inx 12713 29 benefits benefit NNS cord-010092-uftc8inx 12713 30 as as IN cord-010092-uftc8inx 12713 31 reported report VBN cord-010092-uftc8inx 12713 32 in in IN cord-010092-uftc8inx 12713 33 PID PID NNP cord-010092-uftc8inx 12713 34 patients patient NNS cord-010092-uftc8inx 12713 35 . . . cord-010092-uftc8inx 12714 1 Aims aim VBZ cord-010092-uftc8inx 12714 2 : : : cord-010092-uftc8inx 12715 1 To to TO cord-010092-uftc8inx 12715 2 assess assess VB cord-010092-uftc8inx 12715 3 whether whether IN cord-010092-uftc8inx 12715 4 SID SID NNP cord-010092-uftc8inx 12715 5 patients patient NNS cord-010092-uftc8inx 12715 6 experience experience VBP cord-010092-uftc8inx 12715 7 similar similar JJ cord-010092-uftc8inx 12715 8 clinical clinical JJ cord-010092-uftc8inx 12715 9 and and CC cord-010092-uftc8inx 12715 10 QoL qol NN cord-010092-uftc8inx 12715 11 benefits benefit NNS cord-010092-uftc8inx 12715 12 while while IN cord-010092-uftc8inx 12715 13 on on IN cord-010092-uftc8inx 12715 14 IRT IRT NNP cord-010092-uftc8inx 12715 15 as as IN cord-010092-uftc8inx 12715 16 PID PID NNP cord-010092-uftc8inx 12715 17 patients patient NNS cord-010092-uftc8inx 12715 18 . . . cord-010092-uftc8inx 12716 1 Methods method NNS cord-010092-uftc8inx 12716 2 : : : cord-010092-uftc8inx 12717 1 Following follow VBG cord-010092-uftc8inx 12717 2 ethics ethic NNS cord-010092-uftc8inx 12717 3 approval approval NN cord-010092-uftc8inx 12717 4 , , , cord-010092-uftc8inx 12717 5 data datum NNS cord-010092-uftc8inx 12717 6 on on IN cord-010092-uftc8inx 12717 7 dosage dosage NN cord-010092-uftc8inx 12717 8 , , , cord-010092-uftc8inx 12717 9 serum serum NN cord-010092-uftc8inx 12717 10 IgG igg NN cord-010092-uftc8inx 12717 11 trough trough NN cord-010092-uftc8inx 12717 12 levels level NNS cord-010092-uftc8inx 12717 13 and and CC cord-010092-uftc8inx 12717 14 infection infection NN cord-010092-uftc8inx 12717 15 ( ( -LRB- cord-010092-uftc8inx 12717 16 bacterial bacterial JJ cord-010092-uftc8inx 12717 17 , , , cord-010092-uftc8inx 12717 18 viral viral JJ cord-010092-uftc8inx 12717 19 and and CC cord-010092-uftc8inx 12717 20 fungal fungal JJ cord-010092-uftc8inx 12717 21 requiring require VBG cord-010092-uftc8inx 12717 22 treatment treatment NN cord-010092-uftc8inx 12717 23 such such JJ cord-010092-uftc8inx 12717 24 as as IN cord-010092-uftc8inx 12717 25 antibiotics antibiotic NNS cord-010092-uftc8inx 12717 26 ) ) -RRB- cord-010092-uftc8inx 12717 27 was be VBD cord-010092-uftc8inx 12717 28 collected collect VBN cord-010092-uftc8inx 12717 29 from from IN cord-010092-uftc8inx 12717 30 14 14 CD cord-010092-uftc8inx 12717 31 adult adult NN cord-010092-uftc8inx 12717 32 PID pid NN cord-010092-uftc8inx 12717 33 and and CC cord-010092-uftc8inx 12717 34 13 13 CD cord-010092-uftc8inx 12717 35 adult adult NN cord-010092-uftc8inx 12717 36 SID SID NNP cord-010092-uftc8inx 12717 37 patients patient NNS cord-010092-uftc8inx 12717 38 from from IN cord-010092-uftc8inx 12717 39 medical medical JJ cord-010092-uftc8inx 12717 40 records record NNS cord-010092-uftc8inx 12717 41 and and CC cord-010092-uftc8inx 12717 42 pathology pathology NN cord-010092-uftc8inx 12717 43 reports report NNS cord-010092-uftc8inx 12717 44 , , , cord-010092-uftc8inx 12717 45 for for IN cord-010092-uftc8inx 12717 46 their -PRON- PRP$ cord-010092-uftc8inx 12717 47 last last JJ cord-010092-uftc8inx 12717 48 12 12 CD cord-010092-uftc8inx 12717 49 months month NNS cord-010092-uftc8inx 12717 50 of of IN cord-010092-uftc8inx 12717 51 IVIg ivig NN cord-010092-uftc8inx 12717 52 and and CC cord-010092-uftc8inx 12717 53 their -PRON- PRP$ cord-010092-uftc8inx 12717 54 first first JJ cord-010092-uftc8inx 12717 55 12 12 CD cord-010092-uftc8inx 12717 56 months month NNS cord-010092-uftc8inx 12717 57 of of IN cord-010092-uftc8inx 12717 58 SCIg SCIg NNS cord-010092-uftc8inx 12717 59 . . . cord-010092-uftc8inx 12718 1 The the DT cord-010092-uftc8inx 12718 2 starting starting NN cord-010092-uftc8inx 12718 3 and and CC cord-010092-uftc8inx 12718 4 maintenance maintenance NN cord-010092-uftc8inx 12718 5 dose dose NN cord-010092-uftc8inx 12718 6 was be VBD cord-010092-uftc8inx 12718 7 0.4 0.4 CD cord-010092-uftc8inx 12718 8 g g NN cord-010092-uftc8inx 12718 9 / / SYM cord-010092-uftc8inx 12718 10 kg kg NN cord-010092-uftc8inx 12718 11 / / SYM cord-010092-uftc8inx 12718 12 month month NN cord-010092-uftc8inx 12718 13 for for IN cord-010092-uftc8inx 12718 14 IVIg IVIg NNP cord-010092-uftc8inx 12718 15 , , , cord-010092-uftc8inx 12718 16 transitioning transition VBG cord-010092-uftc8inx 12718 17 immediately immediately RB cord-010092-uftc8inx 12718 18 to to IN cord-010092-uftc8inx 12718 19 0.1 0.1 CD cord-010092-uftc8inx 12718 20 g g NN cord-010092-uftc8inx 12718 21 / / SYM cord-010092-uftc8inx 12718 22 kg kg NN cord-010092-uftc8inx 12718 23 / / SYM cord-010092-uftc8inx 12718 24 week week NN cord-010092-uftc8inx 12718 25 for for IN cord-010092-uftc8inx 12718 26 SCIg SCIg NNS cord-010092-uftc8inx 12718 27 without without IN cord-010092-uftc8inx 12718 28 a a DT cord-010092-uftc8inx 12718 29 washout washout NN cord-010092-uftc8inx 12718 30 period period NN cord-010092-uftc8inx 12718 31 . . . cord-010092-uftc8inx 12719 1 A a DT cord-010092-uftc8inx 12719 2 study study NN cord-010092-uftc8inx 12719 3 specific specific JJ cord-010092-uftc8inx 12719 4 questionnaire questionnaire NN cord-010092-uftc8inx 12719 5 was be VBD cord-010092-uftc8inx 12719 6 developed develop VBN cord-010092-uftc8inx 12719 7 to to TO cord-010092-uftc8inx 12719 8 gather gather VB cord-010092-uftc8inx 12719 9 data datum NNS cord-010092-uftc8inx 12719 10 on on IN cord-010092-uftc8inx 12719 11 patient patient JJ cord-010092-uftc8inx 12719 12 perceived perceive VBN cord-010092-uftc8inx 12719 13 side side JJ cord-010092-uftc8inx 12719 14 effects effect NNS cord-010092-uftc8inx 12719 15 , , , cord-010092-uftc8inx 12719 16 treatment treatment NN cord-010092-uftc8inx 12719 17 satisfaction satisfaction NN cord-010092-uftc8inx 12719 18 and and CC cord-010092-uftc8inx 12719 19 impact impact NN cord-010092-uftc8inx 12719 20 of of IN cord-010092-uftc8inx 12719 21 IRT IRT NNP cord-010092-uftc8inx 12719 22 on on IN cord-010092-uftc8inx 12719 23 social social JJ cord-010092-uftc8inx 12719 24 / / SYM cord-010092-uftc8inx 12719 25 family family NN cord-010092-uftc8inx 12719 26 life life NN cord-010092-uftc8inx 12719 27 , , , cord-010092-uftc8inx 12719 28 work work NN cord-010092-uftc8inx 12719 29 / / SYM cord-010092-uftc8inx 12719 30 study study NN cord-010092-uftc8inx 12719 31 and and CC cord-010092-uftc8inx 12719 32 their -PRON- PRP$ cord-010092-uftc8inx 12719 33 overall overall JJ cord-010092-uftc8inx 12719 34 QoL. qol. NN cord-010092-uftc8inx 12720 1 Paired paired JJ cord-010092-uftc8inx 12720 2 t t NN cord-010092-uftc8inx 12720 3 - - HYPH cord-010092-uftc8inx 12720 4 test test NN cord-010092-uftc8inx 12720 5 was be VBD cord-010092-uftc8inx 12720 6 used use VBN cord-010092-uftc8inx 12720 7 for for IN cord-010092-uftc8inx 12720 8 parametric parametric JJ cord-010092-uftc8inx 12720 9 data datum NNS cord-010092-uftc8inx 12720 10 and and CC cord-010092-uftc8inx 12720 11 the the DT cord-010092-uftc8inx 12720 12 Wilcoxon Wilcoxon NNP cord-010092-uftc8inx 12720 13 signed sign VBD cord-010092-uftc8inx 12720 14 - - HYPH cord-010092-uftc8inx 12720 15 rank rank NN cord-010092-uftc8inx 12720 16 test test NN cord-010092-uftc8inx 12720 17 for for IN cord-010092-uftc8inx 12720 18 non non JJ cord-010092-uftc8inx 12720 19 - - JJ cord-010092-uftc8inx 12720 20 parametric parametric JJ cord-010092-uftc8inx 12720 21 data datum NNS cord-010092-uftc8inx 12720 22 . . . cord-010092-uftc8inx 12721 1 Results result NNS cord-010092-uftc8inx 12721 2 : : : cord-010092-uftc8inx 12722 1 SID SID NNP cord-010092-uftc8inx 12722 2 patients patient NNS cord-010092-uftc8inx 12722 3 were be VBD cord-010092-uftc8inx 12722 4 significantly significantly RB cord-010092-uftc8inx 12722 5 older old JJR cord-010092-uftc8inx 12722 6 with with IN cord-010092-uftc8inx 12722 7 a a DT cord-010092-uftc8inx 12722 8 mean mean JJ cord-010092-uftc8inx 12722 9 age age NN cord-010092-uftc8inx 12722 10 of of IN cord-010092-uftc8inx 12722 11 62.9 62.9 CD cord-010092-uftc8inx 12722 12 years year NNS cord-010092-uftc8inx 12722 13 versus versus IN cord-010092-uftc8inx 12722 14 43.4 43.4 CD cord-010092-uftc8inx 12722 15 years year NNS cord-010092-uftc8inx 12722 16 in in IN cord-010092-uftc8inx 12722 17 PID pid NN cord-010092-uftc8inx 12722 18 patients patient NNS cord-010092-uftc8inx 12722 19 ( ( -LRB- cord-010092-uftc8inx 12722 20 P p NN cord-010092-uftc8inx 12722 21 = = SYM cord-010092-uftc8inx 12722 22 0.007 0.007 CD cord-010092-uftc8inx 12722 23 ) ) -RRB- cord-010092-uftc8inx 12722 24 . . . cord-010092-uftc8inx 12723 1 A a DT cord-010092-uftc8inx 12723 2 mean mean NN cord-010092-uftc8inx 12723 3 of of IN cord-010092-uftc8inx 12723 4 three three CD cord-010092-uftc8inx 12723 5 training training NN cord-010092-uftc8inx 12723 6 session session NN cord-010092-uftc8inx 12723 7 was be VBD cord-010092-uftc8inx 12723 8 required require VBN cord-010092-uftc8inx 12723 9 to to TO cord-010092-uftc8inx 12723 10 reach reach VB cord-010092-uftc8inx 12723 11 competency competency NN cord-010092-uftc8inx 12723 12 in in IN cord-010092-uftc8inx 12723 13 SCIg SCIg NNS cord-010092-uftc8inx 12723 14 administration administration NN cord-010092-uftc8inx 12723 15 in in IN cord-010092-uftc8inx 12723 16 both both DT cord-010092-uftc8inx 12723 17 cohorts cohort NNS cord-010092-uftc8inx 12723 18 . . . cord-010092-uftc8inx 12724 1 There there EX cord-010092-uftc8inx 12724 2 was be VBD cord-010092-uftc8inx 12724 3 a a DT cord-010092-uftc8inx 12724 4 trend trend NN cord-010092-uftc8inx 12724 5 of of IN cord-010092-uftc8inx 12724 6 reduced reduce VBN cord-010092-uftc8inx 12724 7 side side NN cord-010092-uftc8inx 12724 8 effects effect NNS cord-010092-uftc8inx 12724 9 on on IN cord-010092-uftc8inx 12724 10 SCIg SCIg NNS cord-010092-uftc8inx 12724 11 for for IN cord-010092-uftc8inx 12724 12 PID PID NNP cord-010092-uftc8inx 12724 13 and and CC cord-010092-uftc8inx 12724 14 SID SID NNP cord-010092-uftc8inx 12724 15 patients patient NNS cord-010092-uftc8inx 12724 16 compared compare VBN cord-010092-uftc8inx 12724 17 to to IN cord-010092-uftc8inx 12724 18 IVIg IVIg NNP cord-010092-uftc8inx 12724 19 , , , cord-010092-uftc8inx 12724 20 with with IN cord-010092-uftc8inx 12724 21 a a DT cord-010092-uftc8inx 12724 22 significant significant JJ cord-010092-uftc8inx 12724 23 reduction reduction NN cord-010092-uftc8inx 12724 24 of of IN cord-010092-uftc8inx 12724 25 headaches headache NNS cord-010092-uftc8inx 12724 26 in in IN cord-010092-uftc8inx 12724 27 the the DT cord-010092-uftc8inx 12724 28 PID PID NNP cord-010092-uftc8inx 12724 29 cohort cohort NN cord-010092-uftc8inx 12724 30 ( ( -LRB- cord-010092-uftc8inx 12724 31 P p NN cord-010092-uftc8inx 12724 32 = = SYM cord-010092-uftc8inx 12724 33 0.041 0.041 CD cord-010092-uftc8inx 12724 34 ) ) -RRB- cord-010092-uftc8inx 12724 35 . . . cord-010092-uftc8inx 12725 1 The the DT cord-010092-uftc8inx 12725 2 majority majority NN cord-010092-uftc8inx 12725 3 of of IN cord-010092-uftc8inx 12725 4 patients patient NNS cord-010092-uftc8inx 12725 5 experienced experience VBD cord-010092-uftc8inx 12725 6 infusion infusion NN cord-010092-uftc8inx 12725 7 site site NN cord-010092-uftc8inx 12725 8 reactions reaction NNS cord-010092-uftc8inx 12725 9 , , , cord-010092-uftc8inx 12725 10 which which WDT cord-010092-uftc8inx 12725 11 were be VBD cord-010092-uftc8inx 12725 12 predominantly predominantly RB cord-010092-uftc8inx 12725 13 perceived perceive VBN cord-010092-uftc8inx 12725 14 as as RB cord-010092-uftc8inx 12725 15 manageable manageable JJ cord-010092-uftc8inx 12725 16 . . . cord-010092-uftc8inx 12726 1 55 55 CD cord-010092-uftc8inx 12726 2 % % NN cord-010092-uftc8inx 12726 3 of of IN cord-010092-uftc8inx 12726 4 infections infection NNS cord-010092-uftc8inx 12726 5 were be VBD cord-010092-uftc8inx 12726 6 respiratory respiratory JJ cord-010092-uftc8inx 12726 7 tract tract JJ cord-010092-uftc8inx 12726 8 infections infection NNS cord-010092-uftc8inx 12726 9 . . . cord-010092-uftc8inx 12727 1 PID PID NNP cord-010092-uftc8inx 12727 2 patients patient NNS cord-010092-uftc8inx 12727 3 had have VBD cord-010092-uftc8inx 12727 4 slightly slightly RB cord-010092-uftc8inx 12727 5 higher high JJR cord-010092-uftc8inx 12727 6 mean mean JJ cord-010092-uftc8inx 12727 7 serum serum NN cord-010092-uftc8inx 12727 8 IgG igg NN cord-010092-uftc8inx 12727 9 trough trough NN cord-010092-uftc8inx 12727 10 levels level NNS cord-010092-uftc8inx 12727 11 with with IN cord-010092-uftc8inx 12727 12 SCIg SCIg NNS cord-010092-uftc8inx 12727 13 ( ( -LRB- cord-010092-uftc8inx 12727 14 9.3 9.3 CD cord-010092-uftc8inx 12727 15 g g NN cord-010092-uftc8inx 12727 16 / / SYM cord-010092-uftc8inx 12727 17 L l NN cord-010092-uftc8inx 12727 18 ) ) -RRB- cord-010092-uftc8inx 12727 19 compared compare VBN cord-010092-uftc8inx 12727 20 to to IN cord-010092-uftc8inx 12727 21 IVIg IVIg NNP cord-010092-uftc8inx 12727 22 ( ( -LRB- cord-010092-uftc8inx 12727 23 8.4 8.4 CD cord-010092-uftc8inx 12727 24 g g NN cord-010092-uftc8inx 12727 25 / / SYM cord-010092-uftc8inx 12727 26 L L NNP cord-010092-uftc8inx 12727 27 ) ) -RRB- cord-010092-uftc8inx 12727 28 , , , cord-010092-uftc8inx 12727 29 and and CC cord-010092-uftc8inx 12727 30 fewer few JJR cord-010092-uftc8inx 12727 31 infections infection NNS cord-010092-uftc8inx 12727 32 on on IN cord-010092-uftc8inx 12727 33 SCIg SCIg NNS cord-010092-uftc8inx 12727 34 than than IN cord-010092-uftc8inx 12727 35 IVIg IVIg NNP cord-010092-uftc8inx 12727 36 ( ( -LRB- cord-010092-uftc8inx 12727 37 mean mean VB cord-010092-uftc8inx 12727 38 annual annual JJ cord-010092-uftc8inx 12727 39 infection infection NN cord-010092-uftc8inx 12727 40 rate rate NN cord-010092-uftc8inx 12727 41 of of IN cord-010092-uftc8inx 12727 42 1.64 1.64 CD cord-010092-uftc8inx 12727 43 vs vs IN cord-010092-uftc8inx 12727 44 2.14 2.14 CD cord-010092-uftc8inx 12727 45 respectively respectively RB cord-010092-uftc8inx 12727 46 ) ) -RRB- cord-010092-uftc8inx 12727 47 . . . cord-010092-uftc8inx 12728 1 SID SID NNP cord-010092-uftc8inx 12728 2 patients patient NNS cord-010092-uftc8inx 12728 3 had have VBD cord-010092-uftc8inx 12728 4 higher high JJR cord-010092-uftc8inx 12728 5 mean mean NNP cord-010092-uftc8inx 12728 6 serum serum NN cord-010092-uftc8inx 12728 7 IgG igg NN cord-010092-uftc8inx 12728 8 trough trough NN cord-010092-uftc8inx 12728 9 levels level NNS cord-010092-uftc8inx 12728 10 on on IN cord-010092-uftc8inx 12728 11 SCIg SCIg NNS cord-010092-uftc8inx 12728 12 ( ( -LRB- cord-010092-uftc8inx 12728 13 8.4 8.4 CD cord-010092-uftc8inx 12728 14 g g NN cord-010092-uftc8inx 12728 15 / / SYM cord-010092-uftc8inx 12728 16 L L NNP cord-010092-uftc8inx 12728 17 ) ) -RRB- cord-010092-uftc8inx 12728 18 than than IN cord-010092-uftc8inx 12728 19 IVIg IVIg NNP cord-010092-uftc8inx 12728 20 ( ( -LRB- cord-010092-uftc8inx 12728 21 7.1 7.1 CD cord-010092-uftc8inx 12728 22 g g NN cord-010092-uftc8inx 12728 23 / / SYM cord-010092-uftc8inx 12728 24 L l NN cord-010092-uftc8inx 12728 25 ) ) -RRB- cord-010092-uftc8inx 12729 1 ( ( -LRB- cord-010092-uftc8inx 12729 2 P p NN cord-010092-uftc8inx 12729 3 = = SYM cord-010092-uftc8inx 12729 4 0.009 0.009 CD cord-010092-uftc8inx 12729 5 ) ) -RRB- cord-010092-uftc8inx 12729 6 but but CC cord-010092-uftc8inx 12729 7 experienced experience VBD cord-010092-uftc8inx 12729 8 more more JJR cord-010092-uftc8inx 12729 9 infections infection NNS cord-010092-uftc8inx 12729 10 while while IN cord-010092-uftc8inx 12729 11 on on IN cord-010092-uftc8inx 12729 12 SCIg SCIg NNS cord-010092-uftc8inx 12729 13 versus versus IN cord-010092-uftc8inx 12729 14 IVIg IVIg NNP cord-010092-uftc8inx 12729 15 ( ( -LRB- cord-010092-uftc8inx 12729 16 mean mean VB cord-010092-uftc8inx 12729 17 annual annual JJ cord-010092-uftc8inx 12729 18 infection infection NN cord-010092-uftc8inx 12729 19 rate rate NN cord-010092-uftc8inx 12729 20 of of IN cord-010092-uftc8inx 12729 21 2.15 2.15 CD cord-010092-uftc8inx 12729 22 vs vs IN cord-010092-uftc8inx 12729 23 1.62 1.62 CD cord-010092-uftc8inx 12729 24 respectively respectively RB cord-010092-uftc8inx 12729 25 ) ) -RRB- cord-010092-uftc8inx 12729 26 . . . cord-010092-uftc8inx 12730 1 The the DT cord-010092-uftc8inx 12730 2 number number NN cord-010092-uftc8inx 12730 3 of of IN cord-010092-uftc8inx 12730 4 hospitalisation hospitalisation NN cord-010092-uftc8inx 12730 5 due due IN cord-010092-uftc8inx 12730 6 to to IN cord-010092-uftc8inx 12730 7 infection infection NN cord-010092-uftc8inx 12730 8 decreased decrease VBD cord-010092-uftc8inx 12730 9 in in IN cord-010092-uftc8inx 12730 10 both both DT cord-010092-uftc8inx 12730 11 cohorts cohort NNS cord-010092-uftc8inx 12730 12 with with IN cord-010092-uftc8inx 12730 13 SCIg SCIg NNS cord-010092-uftc8inx 12730 14 . . . cord-010092-uftc8inx 12731 1 PID PID NNP cord-010092-uftc8inx 12731 2 patients patient NNS cord-010092-uftc8inx 12731 3 perceived perceive VBD cord-010092-uftc8inx 12731 4 that that IN cord-010092-uftc8inx 12731 5 switching switch VBG cord-010092-uftc8inx 12731 6 from from IN cord-010092-uftc8inx 12731 7 IVIg IVIg NNP cord-010092-uftc8inx 12731 8 to to IN cord-010092-uftc8inx 12731 9 SCIg SCIg NNS cord-010092-uftc8inx 12731 10 improved improve VBD cord-010092-uftc8inx 12731 11 their -PRON- PRP$ cord-010092-uftc8inx 12731 12 health health NN cord-010092-uftc8inx 12731 13 and and CC cord-010092-uftc8inx 12731 14 QoL. QoL. NNP cord-010092-uftc8inx 12732 1 In in IN cord-010092-uftc8inx 12732 2 contrast contrast NN cord-010092-uftc8inx 12732 3 SID SID NNP cord-010092-uftc8inx 12732 4 patients patient NNS cord-010092-uftc8inx 12732 5 perceived perceive VBD cord-010092-uftc8inx 12732 6 no no DT cord-010092-uftc8inx 12732 7 improvements improvement NNS cord-010092-uftc8inx 12732 8 in in IN cord-010092-uftc8inx 12732 9 health health NN cord-010092-uftc8inx 12732 10 and and CC cord-010092-uftc8inx 12732 11 QoL. QoL. NNP cord-010092-uftc8inx 12732 12 Summary Summary NNP cord-010092-uftc8inx 12732 13 / / SYM cord-010092-uftc8inx 12732 14 Conclusions Conclusions NNPS cord-010092-uftc8inx 12732 15 : : : cord-010092-uftc8inx 12733 1 Data datum NNS cord-010092-uftc8inx 12733 2 from from IN cord-010092-uftc8inx 12733 3 this this DT cord-010092-uftc8inx 12733 4 pilot pilot NN cord-010092-uftc8inx 12733 5 study study NN cord-010092-uftc8inx 12733 6 suggests suggest VBZ cord-010092-uftc8inx 12733 7 that that IN cord-010092-uftc8inx 12733 8 the the DT cord-010092-uftc8inx 12733 9 clinical clinical JJ cord-010092-uftc8inx 12733 10 and and CC cord-010092-uftc8inx 12733 11 QoL qol JJ cord-010092-uftc8inx 12733 12 impact impact NN cord-010092-uftc8inx 12733 13 of of IN cord-010092-uftc8inx 12733 14 IRT IRT NNP cord-010092-uftc8inx 12733 15 in in IN cord-010092-uftc8inx 12733 16 SID SID NNP cord-010092-uftc8inx 12733 17 patients patient NNS cord-010092-uftc8inx 12733 18 is be VBZ cord-010092-uftc8inx 12733 19 different different JJ cord-010092-uftc8inx 12733 20 to to IN cord-010092-uftc8inx 12733 21 that that DT cord-010092-uftc8inx 12733 22 of of IN cord-010092-uftc8inx 12733 23 PID PID NNP cord-010092-uftc8inx 12733 24 patients patient NNS cord-010092-uftc8inx 12733 25 . . . cord-010092-uftc8inx 12734 1 To to TO cord-010092-uftc8inx 12734 2 support support VB cord-010092-uftc8inx 12734 3 evidence evidence NN cord-010092-uftc8inx 12734 4 based base VBN cord-010092-uftc8inx 12734 5 IRT IRT NNP cord-010092-uftc8inx 12734 6 management management NN cord-010092-uftc8inx 12734 7 and and CC cord-010092-uftc8inx 12734 8 effective effective JJ cord-010092-uftc8inx 12734 9 use use NN cord-010092-uftc8inx 12734 10 of of IN cord-010092-uftc8inx 12734 11 this this DT cord-010092-uftc8inx 12734 12 limited limited JJ cord-010092-uftc8inx 12734 13 and and CC cord-010092-uftc8inx 12734 14 expensive expensive JJ cord-010092-uftc8inx 12734 15 blood blood NN cord-010092-uftc8inx 12734 16 product product NN cord-010092-uftc8inx 12734 17 in in IN cord-010092-uftc8inx 12734 18 SID SID NNP cord-010092-uftc8inx 12734 19 , , , cord-010092-uftc8inx 12734 20 larger large JJR cord-010092-uftc8inx 12734 21 studies study NNS cord-010092-uftc8inx 12734 22 which which WDT cord-010092-uftc8inx 12734 23 account account VBP cord-010092-uftc8inx 12734 24 for for IN cord-010092-uftc8inx 12734 25 different different JJ cord-010092-uftc8inx 12734 26 stages stage NNS cord-010092-uftc8inx 12734 27 of of IN cord-010092-uftc8inx 12734 28 malignancy malignancy NN cord-010092-uftc8inx 12734 29 and and CC cord-010092-uftc8inx 12734 30 associated associated JJ cord-010092-uftc8inx 12734 31 treatment treatment NN cord-010092-uftc8inx 12734 32 regimes regime NNS cord-010092-uftc8inx 12734 33 are be VBP cord-010092-uftc8inx 12734 34 required require VBN cord-010092-uftc8inx 12734 35 . . . cord-010092-uftc8inx 12735 1 Background background NN cord-010092-uftc8inx 12735 2 : : : cord-010092-uftc8inx 12736 1 There there EX cord-010092-uftc8inx 12736 2 is be VBZ cord-010092-uftc8inx 12736 3 an an DT cord-010092-uftc8inx 12736 4 increasing increase VBG cord-010092-uftc8inx 12736 5 platelet platelet NN cord-010092-uftc8inx 12736 6 transfusion transfusion NN cord-010092-uftc8inx 12736 7 for for IN cord-010092-uftc8inx 12736 8 treatment treatment NN cord-010092-uftc8inx 12736 9 and and CC cord-010092-uftc8inx 12736 10 prophylaxis prophylaxis NN cord-010092-uftc8inx 12736 11 of of IN cord-010092-uftc8inx 12736 12 bleeding bleed VBG cord-010092-uftc8inx 12736 13 in in IN cord-010092-uftc8inx 12736 14 patients patient NNS cord-010092-uftc8inx 12736 15 with with IN cord-010092-uftc8inx 12736 16 hematologic hematologic JJ cord-010092-uftc8inx 12736 17 disorders disorder NNS cord-010092-uftc8inx 12736 18 and and CC cord-010092-uftc8inx 12736 19 malignancies malignancy NNS cord-010092-uftc8inx 12736 20 . . . cord-010092-uftc8inx 12737 1 Because because IN cord-010092-uftc8inx 12737 2 of of IN cord-010092-uftc8inx 12737 3 limited limited JJ cord-010092-uftc8inx 12737 4 resources resource NNS cord-010092-uftc8inx 12737 5 , , , cord-010092-uftc8inx 12737 6 leukoreduced leukoreduced JJ cord-010092-uftc8inx 12737 7 platelet platelet NN cord-010092-uftc8inx 12737 8 concentrates concentrate VBZ cord-010092-uftc8inx 12737 9 is be VBZ cord-010092-uftc8inx 12737 10 not not RB cord-010092-uftc8inx 12737 11 yet yet RB cord-010092-uftc8inx 12737 12 implemented implement VBN cord-010092-uftc8inx 12737 13 in in IN cord-010092-uftc8inx 12737 14 most most JJS cord-010092-uftc8inx 12737 15 Indonesian indonesian JJ cord-010092-uftc8inx 12737 16 hospitals hospital NNS cord-010092-uftc8inx 12737 17 . . . cord-010092-uftc8inx 12738 1 In in IN cord-010092-uftc8inx 12738 2 vitro vitro FW cord-010092-uftc8inx 12738 3 platelet platelet NN cord-010092-uftc8inx 12738 4 activation activation NN cord-010092-uftc8inx 12738 5 may may MD cord-010092-uftc8inx 12738 6 cause cause VB cord-010092-uftc8inx 12738 7 morphology morphology NN cord-010092-uftc8inx 12738 8 , , , cord-010092-uftc8inx 12738 9 functional functional JJ cord-010092-uftc8inx 12738 10 , , , cord-010092-uftc8inx 12738 11 and and CC cord-010092-uftc8inx 12738 12 ultrastructure ultrastructure NN cord-010092-uftc8inx 12738 13 changes change NNS cord-010092-uftc8inx 12738 14 . . . cord-010092-uftc8inx 12739 1 Those those DT cord-010092-uftc8inx 12739 2 changes change NNS cord-010092-uftc8inx 12739 3 will will MD cord-010092-uftc8inx 12739 4 reduce reduce VB cord-010092-uftc8inx 12739 5 the the DT cord-010092-uftc8inx 12739 6 platelet platelet NN cord-010092-uftc8inx 12739 7 viability viability NN cord-010092-uftc8inx 12739 8 , , , cord-010092-uftc8inx 12739 9 in in IN cord-010092-uftc8inx 12739 10 vivo vivo NN cord-010092-uftc8inx 12739 11 functions function NNS cord-010092-uftc8inx 12739 12 , , , cord-010092-uftc8inx 12739 13 and and CC cord-010092-uftc8inx 12739 14 clinical clinical JJ cord-010092-uftc8inx 12739 15 efficacy efficacy NN cord-010092-uftc8inx 12739 16 . . . cord-010092-uftc8inx 12740 1 High high JJ cord-010092-uftc8inx 12740 2 platelet platelet NN cord-010092-uftc8inx 12740 3 CD62P cd62p NN cord-010092-uftc8inx 12740 4 expression expression NN cord-010092-uftc8inx 12740 5 is be VBZ cord-010092-uftc8inx 12740 6 the the DT cord-010092-uftc8inx 12740 7 cause cause NN cord-010092-uftc8inx 12740 8 of of IN cord-010092-uftc8inx 12740 9 faster fast JJR cord-010092-uftc8inx 12740 10 platelet platelet NN cord-010092-uftc8inx 12740 11 destruction destruction NN cord-010092-uftc8inx 12740 12 in in IN cord-010092-uftc8inx 12740 13 the the DT cord-010092-uftc8inx 12740 14 reticuloendothelial reticuloendothelial JJ cord-010092-uftc8inx 12740 15 systems system NNS cord-010092-uftc8inx 12740 16 . . . cord-010092-uftc8inx 12741 1 Post post JJ cord-010092-uftc8inx 12741 2 - - JJ cord-010092-uftc8inx 12741 3 transfusion transfusion NN cord-010092-uftc8inx 12741 4 in in IN cord-010092-uftc8inx 12741 5 vivo vivo NN cord-010092-uftc8inx 12741 6 hemostatic hemostatic JJ cord-010092-uftc8inx 12741 7 efficacy efficacy NN cord-010092-uftc8inx 12741 8 can can MD cord-010092-uftc8inx 12741 9 be be VB cord-010092-uftc8inx 12741 10 determined determine VBN cord-010092-uftc8inx 12741 11 by by IN cord-010092-uftc8inx 12741 12 the the DT cord-010092-uftc8inx 12741 13 measurement measurement NN cord-010092-uftc8inx 12741 14 of of IN cord-010092-uftc8inx 12741 15 corrected correct VBN cord-010092-uftc8inx 12741 16 count count NN cord-010092-uftc8inx 12741 17 increment increment NN cord-010092-uftc8inx 12741 18 ( ( -LRB- cord-010092-uftc8inx 12741 19 CCI CCI NNP cord-010092-uftc8inx 12741 20 ) ) -RRB- cord-010092-uftc8inx 12741 21 , , , cord-010092-uftc8inx 12741 22 recovery recovery NN cord-010092-uftc8inx 12741 23 , , , cord-010092-uftc8inx 12741 24 and and CC cord-010092-uftc8inx 12741 25 platelet platelet NN cord-010092-uftc8inx 12741 26 CD62P cd62p NN cord-010092-uftc8inx 12741 27 expression expression NN cord-010092-uftc8inx 12741 28 . . . cord-010092-uftc8inx 12742 1 Aims aim VBZ cord-010092-uftc8inx 12742 2 : : : cord-010092-uftc8inx 12742 3 To to TO cord-010092-uftc8inx 12742 4 analyze analyze VB cord-010092-uftc8inx 12742 5 the the DT cord-010092-uftc8inx 12742 6 increase increase NN cord-010092-uftc8inx 12742 7 of of IN cord-010092-uftc8inx 12742 8 platelet platelet NN cord-010092-uftc8inx 12742 9 CD62P cd62p NN cord-010092-uftc8inx 12742 10 expression expression NN cord-010092-uftc8inx 12742 11 in in IN cord-010092-uftc8inx 12742 12 patients patient NNS cord-010092-uftc8inx 12742 13 of of IN cord-010092-uftc8inx 12742 14 non non JJ cord-010092-uftc8inx 12742 15 - - JJ cord-010092-uftc8inx 12742 16 leukodepleted leukodepleted JJ cord-010092-uftc8inx 12742 17 compared compare VBN cord-010092-uftc8inx 12742 18 to to IN cord-010092-uftc8inx 12742 19 pre pre JJ cord-010092-uftc8inx 12742 20 - - JJ cord-010092-uftc8inx 12742 21 storage storage JJ cord-010092-uftc8inx 12742 22 leukodepleted leukodepleted JJ cord-010092-uftc8inx 12742 23 PC pc NN cord-010092-uftc8inx 12742 24 transfusion transfusion NN cord-010092-uftc8inx 12742 25 . . . cord-010092-uftc8inx 12743 1 Background background NN cord-010092-uftc8inx 12743 2 : : : cord-010092-uftc8inx 12744 1 Haemorrhage Haemorrhage NNP cord-010092-uftc8inx 12744 2 is be VBZ cord-010092-uftc8inx 12744 3 a a DT cord-010092-uftc8inx 12744 4 leading leading JJ cord-010092-uftc8inx 12744 5 cause cause NN cord-010092-uftc8inx 12744 6 of of IN cord-010092-uftc8inx 12744 7 preventable preventable JJ cord-010092-uftc8inx 12744 8 death death NN cord-010092-uftc8inx 12744 9 not not RB cord-010092-uftc8inx 12744 10 only only RB cord-010092-uftc8inx 12744 11 in in IN cord-010092-uftc8inx 12744 12 the the DT cord-010092-uftc8inx 12744 13 military military JJ cord-010092-uftc8inx 12744 14 trauma trauma NN cord-010092-uftc8inx 12744 15 care care NN cord-010092-uftc8inx 12744 16 , , , cord-010092-uftc8inx 12744 17 but but CC cord-010092-uftc8inx 12744 18 also also RB cord-010092-uftc8inx 12744 19 for for IN cord-010092-uftc8inx 12744 20 civilian civilian JJ cord-010092-uftc8inx 12744 21 population population NN cord-010092-uftc8inx 12744 22 suffering suffer VBG cord-010092-uftc8inx 12744 23 accidents accident NNS cord-010092-uftc8inx 12744 24 or or CC cord-010092-uftc8inx 12744 25 bleeding bleed VBG cord-010092-uftc8inx 12744 26 injuries injury NNS cord-010092-uftc8inx 12744 27 in in IN cord-010092-uftc8inx 12744 28 regions region NNS cord-010092-uftc8inx 12744 29 with with IN cord-010092-uftc8inx 12744 30 low low JJ cord-010092-uftc8inx 12744 31 population population NN cord-010092-uftc8inx 12744 32 density density NN cord-010092-uftc8inx 12744 33 where where WRB cord-010092-uftc8inx 12744 34 health health NN cord-010092-uftc8inx 12744 35 services service NNS cord-010092-uftc8inx 12744 36 should should MD cord-010092-uftc8inx 12744 37 reach reach VB cord-010092-uftc8inx 12744 38 people people NNS cord-010092-uftc8inx 12744 39 in in IN cord-010092-uftc8inx 12744 40 remote remote JJ cord-010092-uftc8inx 12744 41 areas area NNS cord-010092-uftc8inx 12744 42 . . . cord-010092-uftc8inx 12745 1 Resuscitation resuscitation NN cord-010092-uftc8inx 12745 2 using use VBG cord-010092-uftc8inx 12745 3 blood blood NN cord-010092-uftc8inx 12745 4 products product NNS cord-010092-uftc8inx 12745 5 and and CC cord-010092-uftc8inx 12745 6 limited limited JJ cord-010092-uftc8inx 12745 7 infusion infusion NN cord-010092-uftc8inx 12745 8 of of IN cord-010092-uftc8inx 12745 9 normal normal JJ cord-010092-uftc8inx 12745 10 saline saline NN cord-010092-uftc8inx 12745 11 improves improve VBZ cord-010092-uftc8inx 12745 12 survival survival NN cord-010092-uftc8inx 12745 13 for for IN cord-010092-uftc8inx 12745 14 critically critically RB cord-010092-uftc8inx 12745 15 bleeding bleed VBG cord-010092-uftc8inx 12745 16 patients patient NNS cord-010092-uftc8inx 12745 17 . . . cord-010092-uftc8inx 12746 1 Nowadays nowadays RB cord-010092-uftc8inx 12746 2 there there EX cord-010092-uftc8inx 12746 3 are be VBP cord-010092-uftc8inx 12746 4 HEMS HEMS NNP cord-010092-uftc8inx 12746 5 programs program NNS cord-010092-uftc8inx 12746 6 ( ( -LRB- cord-010092-uftc8inx 12746 7 Helicopter Helicopter NNP cord-010092-uftc8inx 12746 8 Emergency Emergency NNP cord-010092-uftc8inx 12746 9 Medical Medical NNP cord-010092-uftc8inx 12746 10 System System NNP cord-010092-uftc8inx 12746 11 ) ) -RRB- cord-010092-uftc8inx 12746 12 carrying carry VBG cord-010092-uftc8inx 12746 13 blood blood NN cord-010092-uftc8inx 12746 14 products product NNS cord-010092-uftc8inx 12746 15 around around IN cord-010092-uftc8inx 12746 16 the the DT cord-010092-uftc8inx 12746 17 world world NN cord-010092-uftc8inx 12746 18 . . . cord-010092-uftc8inx 12747 1 The the DT cord-010092-uftc8inx 12747 2 HEMS HEMS NNP cord-010092-uftc8inx 12747 3 in in IN cord-010092-uftc8inx 12747 4 Castilla Castilla NNP cord-010092-uftc8inx 12747 5 - - HYPH cord-010092-uftc8inx 12747 6 La La NNP cord-010092-uftc8inx 12747 7 Mancha Mancha NNP cord-010092-uftc8inx 12747 8 , , , cord-010092-uftc8inx 12747 9 with with IN cord-010092-uftc8inx 12747 10 physician physician NN cord-010092-uftc8inx 12747 11 and and CC cord-010092-uftc8inx 12747 12 nurse nurse NN cord-010092-uftc8inx 12747 13 , , , cord-010092-uftc8inx 12747 14 is be VBZ cord-010092-uftc8inx 12747 15 the the DT cord-010092-uftc8inx 12747 16 first first JJ cord-010092-uftc8inx 12747 17 out out JJ cord-010092-uftc8inx 12747 18 - - HYPH cord-010092-uftc8inx 12747 19 of of IN cord-010092-uftc8inx 12747 20 - - HYPH cord-010092-uftc8inx 12747 21 Hospital Hospital NNP cord-010092-uftc8inx 12747 22 Emergency Emergency NNP cord-010092-uftc8inx 12747 23 Service Service NNP cord-010092-uftc8inx 12747 24 in in IN cord-010092-uftc8inx 12747 25 Spain Spain NNP cord-010092-uftc8inx 12747 26 that that WDT cord-010092-uftc8inx 12747 27 provides provide VBZ cord-010092-uftc8inx 12747 28 packed pack VBN cord-010092-uftc8inx 12747 29 Red Red NNP cord-010092-uftc8inx 12747 30 Blood blood NN cord-010092-uftc8inx 12747 31 Cells cell NNS cord-010092-uftc8inx 12747 32 ( ( -LRB- cord-010092-uftc8inx 12747 33 pRBC prbc NN cord-010092-uftc8inx 12747 34 ) ) -RRB- cord-010092-uftc8inx 12747 35 transfusion transfusion NN cord-010092-uftc8inx 12747 36 where where WRB cord-010092-uftc8inx 12747 37 the the DT cord-010092-uftc8inx 12747 38 accidents accident NNS cord-010092-uftc8inx 12747 39 happen happen VBP cord-010092-uftc8inx 12747 40 without without IN cord-010092-uftc8inx 12747 41 delaying delay VBG cord-010092-uftc8inx 12747 42 the the DT cord-010092-uftc8inx 12747 43 transport transport NN cord-010092-uftc8inx 12747 44 to to IN cord-010092-uftc8inx 12747 45 the the DT cord-010092-uftc8inx 12747 46 proper proper JJ cord-010092-uftc8inx 12747 47 Hospital Hospital NNP cord-010092-uftc8inx 12747 48 for for IN cord-010092-uftc8inx 12747 49 definitive definitive JJ cord-010092-uftc8inx 12747 50 treatment treatment NN cord-010092-uftc8inx 12747 51 . . . cord-010092-uftc8inx 12748 1 This this DT cord-010092-uftc8inx 12748 2 program program NN cord-010092-uftc8inx 12748 3 has have VBZ cord-010092-uftc8inx 12748 4 been be VBN cord-010092-uftc8inx 12748 5 developed develop VBN cord-010092-uftc8inx 12748 6 between between IN cord-010092-uftc8inx 12748 7 the the DT cord-010092-uftc8inx 12748 8 Blood Blood NNP cord-010092-uftc8inx 12748 9 Center Center NNP cord-010092-uftc8inx 12748 10 of of IN cord-010092-uftc8inx 12748 11 Ciudad Ciudad NNP cord-010092-uftc8inx 12748 12 Real Real NNP cord-010092-uftc8inx 12748 13 and and CC cord-010092-uftc8inx 12748 14 the the DT cord-010092-uftc8inx 12748 15 HEMS HEMS NNP cord-010092-uftc8inx 12748 16 team team NN cord-010092-uftc8inx 12748 17 ( ( -LRB- cord-010092-uftc8inx 12748 18 ' ' `` cord-010092-uftc8inx 12748 19 Gigante Gigante NNP cord-010092-uftc8inx 12748 20 2 2 CD cord-010092-uftc8inx 12748 21 ' ' '' cord-010092-uftc8inx 12748 22 , , , cord-010092-uftc8inx 12748 23 Emergency Emergency NNP cord-010092-uftc8inx 12748 24 Service Service NNP cord-010092-uftc8inx 12748 25 Castilla Castilla NNP cord-010092-uftc8inx 12748 26 - - HYPH cord-010092-uftc8inx 12748 27 La La NNP cord-010092-uftc8inx 12748 28 Mancha Mancha NNP cord-010092-uftc8inx 12748 29 ) ) -RRB- cord-010092-uftc8inx 12748 30 . . . cord-010092-uftc8inx 12749 1 The the DT cord-010092-uftc8inx 12749 2 goal goal NN cord-010092-uftc8inx 12749 3 of of IN cord-010092-uftc8inx 12749 4 the the DT cord-010092-uftc8inx 12749 5 designed design VBN cord-010092-uftc8inx 12749 6 protocol protocol NN cord-010092-uftc8inx 12749 7 was be VBD cord-010092-uftc8inx 12749 8 to to TO cord-010092-uftc8inx 12749 9 preserve preserve VB cord-010092-uftc8inx 12749 10 the the DT cord-010092-uftc8inx 12749 11 properties property NNS cord-010092-uftc8inx 12749 12 of of IN cord-010092-uftc8inx 12749 13 the the DT cord-010092-uftc8inx 12749 14 product product NN cord-010092-uftc8inx 12749 15 to to TO cord-010092-uftc8inx 12749 16 be be VB cord-010092-uftc8inx 12749 17 transfused transfuse VBN cord-010092-uftc8inx 12749 18 in in IN cord-010092-uftc8inx 12749 19 out out IN cord-010092-uftc8inx 12749 20 - - HYPH cord-010092-uftc8inx 12749 21 of of IN cord-010092-uftc8inx 12749 22 - - HYPH cord-010092-uftc8inx 12749 23 hospital hospital NN cord-010092-uftc8inx 12749 24 environment environment NN cord-010092-uftc8inx 12749 25 by by IN cord-010092-uftc8inx 12749 26 HEMS HEMS NNP cord-010092-uftc8inx 12749 27 teams team NNS cord-010092-uftc8inx 12749 28 . . . cord-010092-uftc8inx 12750 1 Aims aim VBZ cord-010092-uftc8inx 12750 2 : : : cord-010092-uftc8inx 12750 3 To to TO cord-010092-uftc8inx 12750 4 describe describe VB cord-010092-uftc8inx 12750 5 the the DT cord-010092-uftc8inx 12750 6 process process NN cord-010092-uftc8inx 12750 7 for for IN cord-010092-uftc8inx 12750 8 out out IN cord-010092-uftc8inx 12750 9 - - HYPH cord-010092-uftc8inx 12750 10 of of IN cord-010092-uftc8inx 12750 11 - - HYPH cord-010092-uftc8inx 12750 12 hospital hospital NN cord-010092-uftc8inx 12750 13 pRBC prbc JJ cord-010092-uftc8inx 12750 14 transfusion transfusion NN cord-010092-uftc8inx 12750 15 in in IN cord-010092-uftc8inx 12750 16 HEMS HEMS NNP cord-010092-uftc8inx 12750 17 of of IN cord-010092-uftc8inx 12750 18 Ciudad Ciudad NNP cord-010092-uftc8inx 12750 19 - - HYPH cord-010092-uftc8inx 12750 20 Real Real NNP cord-010092-uftc8inx 12750 21 . . . cord-010092-uftc8inx 12751 1 The the DT cord-010092-uftc8inx 12751 2 protocol protocol NN cord-010092-uftc8inx 12751 3 for for IN cord-010092-uftc8inx 12751 4 out out IN cord-010092-uftc8inx 12751 5 - - HYPH cord-010092-uftc8inx 12751 6 of of IN cord-010092-uftc8inx 12751 7 - - HYPH cord-010092-uftc8inx 12751 8 hospital hospital NN cord-010092-uftc8inx 12751 9 blood blood NN cord-010092-uftc8inx 12751 10 transfusion transfusion NN cord-010092-uftc8inx 12751 11 was be VBD cord-010092-uftc8inx 12751 12 developed develop VBN cord-010092-uftc8inx 12751 13 according accord VBG cord-010092-uftc8inx 12751 14 to to IN cord-010092-uftc8inx 12751 15 criteria criterion NNS cord-010092-uftc8inx 12751 16 of of IN cord-010092-uftc8inx 12751 17 medical medical JJ cord-010092-uftc8inx 12751 18 indications indication NNS cord-010092-uftc8inx 12751 19 and and CC cord-010092-uftc8inx 12751 20 security security NN cord-010092-uftc8inx 12751 21 , , , cord-010092-uftc8inx 12751 22 monitoring monitoring NN cord-010092-uftc8inx 12751 23 , , , cord-010092-uftc8inx 12751 24 and and CC cord-010092-uftc8inx 12751 25 tracking tracking NN cord-010092-uftc8inx 12751 26 of of IN cord-010092-uftc8inx 12751 27 the the DT cord-010092-uftc8inx 12751 28 product product NN cord-010092-uftc8inx 12751 29 . . . cord-010092-uftc8inx 12752 1 Methods method NNS cord-010092-uftc8inx 12752 2 : : : cord-010092-uftc8inx 12752 3 Data datum NNS cord-010092-uftc8inx 12752 4 for for IN cord-010092-uftc8inx 12752 5 the the DT cord-010092-uftc8inx 12752 6 observational observational NNP cord-010092-uftc8inx 12752 7 retrospective retrospective JJ cord-010092-uftc8inx 12752 8 study study NN cord-010092-uftc8inx 12752 9 were be VBD cord-010092-uftc8inx 12752 10 collected collect VBN cord-010092-uftc8inx 12752 11 from from IN cord-010092-uftc8inx 12752 12 June June NNP cord-010092-uftc8inx 12752 13 2014 2014 CD cord-010092-uftc8inx 12752 14 to to IN cord-010092-uftc8inx 12752 15 August August NNP cord-010092-uftc8inx 12752 16 2018 2018 CD cord-010092-uftc8inx 12752 17 . . . cord-010092-uftc8inx 12753 1 The the DT cord-010092-uftc8inx 12753 2 medical medical JJ cord-010092-uftc8inx 12753 3 helicopter helicopter NN cord-010092-uftc8inx 12753 4 ( ( -LRB- cord-010092-uftc8inx 12753 5 EC EC NNP cord-010092-uftc8inx 12753 6 145T2 145T2 NNP cord-010092-uftc8inx 12753 7 ) ) -RRB- cord-010092-uftc8inx 12753 8 was be VBD cord-010092-uftc8inx 12753 9 provided provide VBN cord-010092-uftc8inx 12753 10 with with IN cord-010092-uftc8inx 12753 11 two two CD cord-010092-uftc8inx 12753 12 pRBC pRBC NNS cord-010092-uftc8inx 12753 13 O o NN cord-010092-uftc8inx 12753 14 Rh(D rh(d NN cord-010092-uftc8inx 12753 15 ) ) -RRB- cord-010092-uftc8inx 12753 16 negative negative JJ cord-010092-uftc8inx 12753 17 . . . cord-010092-uftc8inx 12754 1 The the DT cord-010092-uftc8inx 12754 2 Shock Shock NNP cord-010092-uftc8inx 12754 3 Index Index NNP cord-010092-uftc8inx 12754 4 was be VBD cord-010092-uftc8inx 12754 5 selected select VBN cord-010092-uftc8inx 12754 6 for for IN cord-010092-uftc8inx 12754 7 the the DT cord-010092-uftc8inx 12754 8 indication indication NN cord-010092-uftc8inx 12754 9 for for IN cord-010092-uftc8inx 12754 10 transfusion transfusion NN cord-010092-uftc8inx 12754 11 according accord VBG cord-010092-uftc8inx 12754 12 to to IN cord-010092-uftc8inx 12754 13 the the DT cord-010092-uftc8inx 12754 14 literature literature NN cord-010092-uftc8inx 12754 15 revised revise VBN cord-010092-uftc8inx 12754 16 and and CC cord-010092-uftc8inx 12754 17 as as IN cord-010092-uftc8inx 12754 18 a a DT cord-010092-uftc8inx 12754 19 simple simple JJ cord-010092-uftc8inx 12754 20 rate rate NN cord-010092-uftc8inx 12754 21 to to TO cord-010092-uftc8inx 12754 22 obtain obtain VB cord-010092-uftc8inx 12754 23 out out RB cord-010092-uftc8inx 12754 24 - - HYPH cord-010092-uftc8inx 12754 25 of of IN cord-010092-uftc8inx 12754 26 - - HYPH cord-010092-uftc8inx 12754 27 hospital hospital NN cord-010092-uftc8inx 12754 28 data datum NNS cord-010092-uftc8inx 12754 29 . . . cord-010092-uftc8inx 12755 1 To to TO cord-010092-uftc8inx 12755 2 achieve achieve VB cord-010092-uftc8inx 12755 3 the the DT cord-010092-uftc8inx 12755 4 feasibility feasibility NN cord-010092-uftc8inx 12755 5 and and CC cord-010092-uftc8inx 12755 6 preservation preservation NN cord-010092-uftc8inx 12755 7 of of IN cord-010092-uftc8inx 12755 8 the the DT cord-010092-uftc8inx 12755 9 pRBC prbc JJ cord-010092-uftc8inx 12755 10 a a DT cord-010092-uftc8inx 12755 11 prospective prospective JJ cord-010092-uftc8inx 12755 12 monitoring monitoring NN cord-010092-uftc8inx 12755 13 of of IN cord-010092-uftc8inx 12755 14 volume volume NN cord-010092-uftc8inx 12755 15 was be VBD cord-010092-uftc8inx 12755 16 established establish VBN cord-010092-uftc8inx 12755 17 , , , cord-010092-uftc8inx 12755 18 haematocrit haematocrit NNP cord-010092-uftc8inx 12755 19 , , , cord-010092-uftc8inx 12755 20 haemoglobin haemoglobin NN cord-010092-uftc8inx 12755 21 , , , cord-010092-uftc8inx 12755 22 leucocytes leucocytes NNP cord-010092-uftc8inx 12755 23 , , , cord-010092-uftc8inx 12755 24 coulter coulter NNP cord-010092-uftc8inx 12755 25 , , , cord-010092-uftc8inx 12755 26 hemolysis hemolysis NN cord-010092-uftc8inx 12755 27 and and CC cord-010092-uftc8inx 12755 28 microbiological microbiological JJ cord-010092-uftc8inx 12755 29 culture culture NN cord-010092-uftc8inx 12755 30 . . . cord-010092-uftc8inx 12756 1 Blood Blood NNP cord-010092-uftc8inx 12756 2 Center Center NNP cord-010092-uftc8inx 12756 3 established establish VBD cord-010092-uftc8inx 12756 4 two two CD cord-010092-uftc8inx 12756 5 groups group NNS cord-010092-uftc8inx 12756 6 : : : cord-010092-uftc8inx 12756 7 the the DT cord-010092-uftc8inx 12756 8 case case NN cord-010092-uftc8inx 12756 9 group group NN cord-010092-uftc8inx 12756 10 for for IN cord-010092-uftc8inx 12756 11 the the DT cord-010092-uftc8inx 12756 12 pRBC prbc NN cord-010092-uftc8inx 12756 13 kept keep VBD cord-010092-uftc8inx 12756 14 in in IN cord-010092-uftc8inx 12756 15 the the DT cord-010092-uftc8inx 12756 16 HEMS HEMS NNP cord-010092-uftc8inx 12756 17 Base Base NNP cord-010092-uftc8inx 12756 18 and and CC cord-010092-uftc8inx 12756 19 Helicopter Helicopter NNP cord-010092-uftc8inx 12756 20 and and CC cord-010092-uftc8inx 12756 21 the the DT cord-010092-uftc8inx 12756 22 control control NN cord-010092-uftc8inx 12756 23 group group NN cord-010092-uftc8inx 12756 24 for for IN cord-010092-uftc8inx 12756 25 the the DT cord-010092-uftc8inx 12756 26 units unit NNS cord-010092-uftc8inx 12756 27 remaining remain VBG cord-010092-uftc8inx 12756 28 in in IN cord-010092-uftc8inx 12756 29 the the DT cord-010092-uftc8inx 12756 30 Blood Blood NNP cord-010092-uftc8inx 12756 31 Center Center NNP cord-010092-uftc8inx 12756 32 with with IN cord-010092-uftc8inx 12756 33 standardized standardized JJ cord-010092-uftc8inx 12756 34 blood blood NN cord-010092-uftc8inx 12756 35 conservation conservation NN cord-010092-uftc8inx 12756 36 . . . cord-010092-uftc8inx 12757 1 For for IN cord-010092-uftc8inx 12757 2 both both DT cord-010092-uftc8inx 12757 3 groups group NNS cord-010092-uftc8inx 12757 4 , , , cord-010092-uftc8inx 12757 5 control control NN cord-010092-uftc8inx 12757 6 and and CC cord-010092-uftc8inx 12757 7 comparison comparison NN cord-010092-uftc8inx 12757 8 of of IN cord-010092-uftc8inx 12757 9 immediately immediately RB cord-010092-uftc8inx 12757 10 obtained obtain VBN cord-010092-uftc8inx 12757 11 hematologic hematologic JJ cord-010092-uftc8inx 12757 12 analyses analysis NNS cord-010092-uftc8inx 12757 13 , , , cord-010092-uftc8inx 12757 14 and and CC cord-010092-uftc8inx 12757 15 35 35 CD cord-010092-uftc8inx 12757 16 days day NNS cord-010092-uftc8inx 12757 17 after after IN cord-010092-uftc8inx 12757 18 collection collection NN cord-010092-uftc8inx 12757 19 , , , cord-010092-uftc8inx 12757 20 were be VBD cord-010092-uftc8inx 12757 21 performed perform VBN cord-010092-uftc8inx 12757 22 . . . cord-010092-uftc8inx 12758 1 The the DT cord-010092-uftc8inx 12758 2 statistical statistical JJ cord-010092-uftc8inx 12758 3 analysis analysis NN cord-010092-uftc8inx 12758 4 used use VBD cord-010092-uftc8inx 12758 5 SPSS SPSS NNP cord-010092-uftc8inx 12758 6 23.0 23.0 CD cord-010092-uftc8inx 12758 7 version version NN cord-010092-uftc8inx 12758 8 ( ( -LRB- cord-010092-uftc8inx 12758 9 significance significance NN cord-010092-uftc8inx 12758 10 P p NN cord-010092-uftc8inx 12758 11 < < XX cord-010092-uftc8inx 12758 12 0,05 0,05 NN cord-010092-uftc8inx 12758 13 ) ) -RRB- cord-010092-uftc8inx 12758 14 . . . cord-010092-uftc8inx 12759 1 Results result NNS cord-010092-uftc8inx 12759 2 : : : cord-010092-uftc8inx 12760 1 138 138 CD cord-010092-uftc8inx 12760 2 pRBC prbc JJ cord-010092-uftc8inx 12760 3 samples sample NNS cord-010092-uftc8inx 12760 4 were be VBD cord-010092-uftc8inx 12760 5 evaluated evaluate VBN cord-010092-uftc8inx 12760 6 , , , cord-010092-uftc8inx 12760 7 48,5 48,5 CD cord-010092-uftc8inx 12760 8 % % NN cord-010092-uftc8inx 12760 9 ( ( -LRB- cord-010092-uftc8inx 12760 10 67 67 CD cord-010092-uftc8inx 12760 11 ) ) -RRB- cord-010092-uftc8inx 12760 12 from from IN cord-010092-uftc8inx 12760 13 case case NN cord-010092-uftc8inx 12760 14 group group NN cord-010092-uftc8inx 12760 15 and and CC cord-010092-uftc8inx 12760 16 51,5 51,5 CD cord-010092-uftc8inx 12760 17 % % NN cord-010092-uftc8inx 12760 18 ( ( -LRB- cord-010092-uftc8inx 12760 19 71 71 CD cord-010092-uftc8inx 12760 20 ) ) -RRB- cord-010092-uftc8inx 12760 21 from from IN cord-010092-uftc8inx 12760 22 control control NN cord-010092-uftc8inx 12760 23 group group NN cord-010092-uftc8inx 12760 24 . . . cord-010092-uftc8inx 12761 1 Analyses analysis NNS cord-010092-uftc8inx 12761 2 were be VBD cord-010092-uftc8inx 12761 3 tested test VBN cord-010092-uftc8inx 12761 4 day day NN cord-010092-uftc8inx 12761 5 1 1 CD cord-010092-uftc8inx 12761 6 and and CC cord-010092-uftc8inx 12761 7 day day NN cord-010092-uftc8inx 12761 8 35 35 CD cord-010092-uftc8inx 12761 9 after after IN cord-010092-uftc8inx 12761 10 collection collection NN cord-010092-uftc8inx 12761 11 . . . cord-010092-uftc8inx 12762 1 Haemolysis Haemolysis NNP cord-010092-uftc8inx 12762 2 was be VBD cord-010092-uftc8inx 12762 3 not not RB cord-010092-uftc8inx 12762 4 observed observe VBN cord-010092-uftc8inx 12762 5 . . . cord-010092-uftc8inx 12763 1 All all DT cord-010092-uftc8inx 12763 2 cultures culture NNS cord-010092-uftc8inx 12763 3 were be VBD cord-010092-uftc8inx 12763 4 negative negative JJ cord-010092-uftc8inx 12763 5 . . . cord-010092-uftc8inx 12764 1 Although although IN cord-010092-uftc8inx 12764 2 significant significant JJ cord-010092-uftc8inx 12764 3 differences difference NNS cord-010092-uftc8inx 12764 4 were be VBD cord-010092-uftc8inx 12764 5 found find VBN cord-010092-uftc8inx 12764 6 between between IN cord-010092-uftc8inx 12764 7 the the DT cord-010092-uftc8inx 12764 8 parameter parameter NN cord-010092-uftc8inx 12764 9 in in IN cord-010092-uftc8inx 12764 10 the the DT cord-010092-uftc8inx 12764 11 value value NN cord-010092-uftc8inx 12764 12 of of IN cord-010092-uftc8inx 12764 13 before before NN cord-010092-uftc8inx 12764 14 - - HYPH cord-010092-uftc8inx 12764 15 after after RB cord-010092-uftc8inx 12764 16 in in IN cord-010092-uftc8inx 12764 17 the the DT cord-010092-uftc8inx 12764 18 value value NN cord-010092-uftc8inx 12764 19 of of IN cord-010092-uftc8inx 12764 20 the the DT cord-010092-uftc8inx 12764 21 hematocrit hematocrit NN cord-010092-uftc8inx 12764 22 , , , cord-010092-uftc8inx 12764 23 leukocytes leukocyte NNS cord-010092-uftc8inx 12764 24 and and CC cord-010092-uftc8inx 12764 25 coulter coulter NNP cord-010092-uftc8inx 12764 26 , , , cord-010092-uftc8inx 12764 27 there there EX cord-010092-uftc8inx 12764 28 are be VBP cord-010092-uftc8inx 12764 29 no no DT cord-010092-uftc8inx 12764 30 differences difference NNS cord-010092-uftc8inx 12764 31 between between IN cord-010092-uftc8inx 12764 32 the the DT cord-010092-uftc8inx 12764 33 pRBC prbc NN cord-010092-uftc8inx 12764 34 that that WDT cord-010092-uftc8inx 12764 35 flew fly VBD cord-010092-uftc8inx 12764 36 and and CC cord-010092-uftc8inx 12764 37 those those DT cord-010092-uftc8inx 12764 38 conserved conserve VBN cord-010092-uftc8inx 12764 39 in in IN cord-010092-uftc8inx 12764 40 the the DT cord-010092-uftc8inx 12764 41 Transfusion Transfusion NNP cord-010092-uftc8inx 12764 42 - - HYPH cord-010092-uftc8inx 12764 43 Service Service NNP cord-010092-uftc8inx 12764 44 . . . cord-010092-uftc8inx 12765 1 All all DT cord-010092-uftc8inx 12765 2 results result NNS cord-010092-uftc8inx 12765 3 comply comply VBP cord-010092-uftc8inx 12765 4 with with IN cord-010092-uftc8inx 12765 5 current current JJ cord-010092-uftc8inx 12765 6 legislation legislation NN cord-010092-uftc8inx 12765 7 and and CC cord-010092-uftc8inx 12765 8 blood blood NN cord-010092-uftc8inx 12765 9 transfusion transfusion NN cord-010092-uftc8inx 12765 10 standards standard NNS cord-010092-uftc8inx 12765 11 . . . cord-010092-uftc8inx 12766 1 There there EX cord-010092-uftc8inx 12766 2 have have VBP cord-010092-uftc8inx 12766 3 been be VBN cord-010092-uftc8inx 12766 4 administered administer VBN cord-010092-uftc8inx 12766 5 35 35 CD cord-010092-uftc8inx 12766 6 pRBC prbc JJ cord-010092-uftc8inx 12766 7 transfusion transfusion NN cord-010092-uftc8inx 12766 8 to to IN cord-010092-uftc8inx 12766 9 28 28 CD cord-010092-uftc8inx 12766 10 patients patient NNS cord-010092-uftc8inx 12766 11 during during IN cord-010092-uftc8inx 12766 12 out out RB cord-010092-uftc8inx 12766 13 - - HYPH cord-010092-uftc8inx 12766 14 of of IN cord-010092-uftc8inx 12766 15 - - HYPH cord-010092-uftc8inx 12766 16 hospital hospital NN cord-010092-uftc8inx 12766 17 advanced advanced JJ cord-010092-uftc8inx 12766 18 medical medical JJ cord-010092-uftc8inx 12766 19 assistance assistance NN cord-010092-uftc8inx 12766 20 . . . cord-010092-uftc8inx 12767 1 No no DT cord-010092-uftc8inx 12767 2 post post JJ cord-010092-uftc8inx 12767 3 - - JJ cord-010092-uftc8inx 12767 4 transfusion transfusion JJ cord-010092-uftc8inx 12767 5 reactions reaction NNS cord-010092-uftc8inx 12767 6 have have VBP cord-010092-uftc8inx 12767 7 been be VBN cord-010092-uftc8inx 12767 8 registered register VBN cord-010092-uftc8inx 12767 9 . . . cord-010092-uftc8inx 12768 1 pRBC pRBC NNP cord-010092-uftc8inx 12768 2 units unit NNS cord-010092-uftc8inx 12768 3 have have VBP cord-010092-uftc8inx 12768 4 a a DT cord-010092-uftc8inx 12768 5 35-day 35-day CD cord-010092-uftc8inx 12768 6 rotation rotation NN cord-010092-uftc8inx 12768 7 to to TO cord-010092-uftc8inx 12768 8 allow allow VB cord-010092-uftc8inx 12768 9 the the DT cord-010092-uftc8inx 12768 10 use use NN cord-010092-uftc8inx 12768 11 of of IN cord-010092-uftc8inx 12768 12 the the DT cord-010092-uftc8inx 12768 13 units unit NNS cord-010092-uftc8inx 12768 14 in in IN cord-010092-uftc8inx 12768 15 the the DT cord-010092-uftc8inx 12768 16 Hospital Hospital NNP cord-010092-uftc8inx 12768 17 after after IN cord-010092-uftc8inx 12768 18 achieving achieve VBG cord-010092-uftc8inx 12768 19 their -PRON- PRP$ cord-010092-uftc8inx 12768 20 optimal optimal JJ cord-010092-uftc8inx 12768 21 status status NN cord-010092-uftc8inx 12768 22 . . . cord-010092-uftc8inx 12769 1 Summary Summary NNP cord-010092-uftc8inx 12769 2 / / SYM cord-010092-uftc8inx 12769 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 12769 4 : : : cord-010092-uftc8inx 12770 1 The the DT cord-010092-uftc8inx 12770 2 out out JJ cord-010092-uftc8inx 12770 3 - - HYPH cord-010092-uftc8inx 12770 4 of of IN cord-010092-uftc8inx 12770 5 - - HYPH cord-010092-uftc8inx 12770 6 hospital hospital NN cord-010092-uftc8inx 12770 7 Transfusion transfusion NN cord-010092-uftc8inx 12770 8 protocol protocol NN cord-010092-uftc8inx 12770 9 designed design VBN cord-010092-uftc8inx 12770 10 to to TO cord-010092-uftc8inx 12770 11 transport transport VB cord-010092-uftc8inx 12770 12 blood blood NN cord-010092-uftc8inx 12770 13 ( ( -LRB- cord-010092-uftc8inx 12770 14 pRBC pRBC NNP cord-010092-uftc8inx 12770 15 ) ) -RRB- cord-010092-uftc8inx 12770 16 in in IN cord-010092-uftc8inx 12770 17 the the DT cord-010092-uftc8inx 12770 18 helicopter helicopter NN cord-010092-uftc8inx 12770 19 for for IN cord-010092-uftc8inx 12770 20 HEMS HEMS NNP cord-010092-uftc8inx 12770 21 has have VBZ cord-010092-uftc8inx 12770 22 demonstrated demonstrate VBN cord-010092-uftc8inx 12770 23 to to TO cord-010092-uftc8inx 12770 24 keep keep VB cord-010092-uftc8inx 12770 25 the the DT cord-010092-uftc8inx 12770 26 standard standard JJ cord-010092-uftc8inx 12770 27 conditions condition NNS cord-010092-uftc8inx 12770 28 and and CC cord-010092-uftc8inx 12770 29 properties property NNS cord-010092-uftc8inx 12770 30 of of IN cord-010092-uftc8inx 12770 31 the the DT cord-010092-uftc8inx 12770 32 product product NN cord-010092-uftc8inx 12770 33 to to TO cord-010092-uftc8inx 12770 34 be be VB cord-010092-uftc8inx 12770 35 considered consider VBN cord-010092-uftc8inx 12770 36 useful useful JJ cord-010092-uftc8inx 12770 37 in in IN cord-010092-uftc8inx 12770 38 the the DT cord-010092-uftc8inx 12770 39 treatment treatment NN cord-010092-uftc8inx 12770 40 for for IN cord-010092-uftc8inx 12770 41 critically critically RB cord-010092-uftc8inx 12770 42 bleeding bleed VBG cord-010092-uftc8inx 12770 43 patients patient NNS cord-010092-uftc8inx 12770 44 in in IN cord-010092-uftc8inx 12770 45 the the DT cord-010092-uftc8inx 12770 46 out out JJ cord-010092-uftc8inx 12770 47 - - HYPH cord-010092-uftc8inx 12770 48 of of IN cord-010092-uftc8inx 12770 49 - - HYPH cord-010092-uftc8inx 12770 50 hospital hospital NN cord-010092-uftc8inx 12770 51 . . . cord-010092-uftc8inx 12771 1 Background background NN cord-010092-uftc8inx 12771 2 : : : cord-010092-uftc8inx 12772 1 Early early JJ cord-010092-uftc8inx 12772 2 and and CC cord-010092-uftc8inx 12772 3 adequate adequate JJ cord-010092-uftc8inx 12772 4 treatment treatment NN cord-010092-uftc8inx 12772 5 of of IN cord-010092-uftc8inx 12772 6 major major JJ cord-010092-uftc8inx 12772 7 bleeding bleeding NN cord-010092-uftc8inx 12772 8 is be VBZ cord-010092-uftc8inx 12772 9 important important JJ cord-010092-uftc8inx 12772 10 for for IN cord-010092-uftc8inx 12772 11 survival survival NN cord-010092-uftc8inx 12772 12 and and CC cord-010092-uftc8inx 12772 13 a a DT cord-010092-uftc8inx 12772 14 good good JJ cord-010092-uftc8inx 12772 15 outcome outcome NN cord-010092-uftc8inx 12772 16 . . . cord-010092-uftc8inx 12773 1 Blood blood NN cord-010092-uftc8inx 12773 2 and and CC cord-010092-uftc8inx 12773 3 plasma plasma NN cord-010092-uftc8inx 12773 4 are be VBP cord-010092-uftc8inx 12773 5 given give VBN cord-010092-uftc8inx 12773 6 increasingly increasingly RB cord-010092-uftc8inx 12773 7 early early RB cord-010092-uftc8inx 12773 8 including include VBG cord-010092-uftc8inx 12773 9 before before IN cord-010092-uftc8inx 12773 10 hospital hospital NN cord-010092-uftc8inx 12773 11 admission admission NN cord-010092-uftc8inx 12773 12 in in IN cord-010092-uftc8inx 12773 13 trauma trauma NN cord-010092-uftc8inx 12773 14 based base VBN cord-010092-uftc8inx 12773 15 on on IN cord-010092-uftc8inx 12773 16 successes success NNS cord-010092-uftc8inx 12773 17 reported report VBN cord-010092-uftc8inx 12773 18 from from IN cord-010092-uftc8inx 12773 19 combat combat NN cord-010092-uftc8inx 12773 20 experience experience NN cord-010092-uftc8inx 12773 21 . . . cord-010092-uftc8inx 12774 1 In in IN cord-010092-uftc8inx 12774 2 2010 2010 CD cord-010092-uftc8inx 12774 3 the the DT cord-010092-uftc8inx 12774 4 National National NNP cord-010092-uftc8inx 12774 5 Patient Patient NNP cord-010092-uftc8inx 12774 6 Safety Safety NNP cord-010092-uftc8inx 12774 7 Agency Agency NNP cord-010092-uftc8inx 12774 8 issued issue VBD cord-010092-uftc8inx 12774 9 a a DT cord-010092-uftc8inx 12774 10 rapid rapid JJ cord-010092-uftc8inx 12774 11 response response NN cord-010092-uftc8inx 12774 12 report report NN cord-010092-uftc8inx 12774 13 requiring require VBG cord-010092-uftc8inx 12774 14 National National NNP cord-010092-uftc8inx 12774 15 Health Health NNP cord-010092-uftc8inx 12774 16 Service Service NNP cord-010092-uftc8inx 12774 17 hospitals hospital NNS cord-010092-uftc8inx 12774 18 in in IN cord-010092-uftc8inx 12774 19 England England NNP cord-010092-uftc8inx 12774 20 to to TO cord-010092-uftc8inx 12774 21 take take VB cord-010092-uftc8inx 12774 22 actions action NNS cord-010092-uftc8inx 12774 23 to to TO cord-010092-uftc8inx 12774 24 improve improve VB cord-010092-uftc8inx 12774 25 provision provision NN cord-010092-uftc8inx 12774 26 of of IN cord-010092-uftc8inx 12774 27 blood blood NN cord-010092-uftc8inx 12774 28 in in IN cord-010092-uftc8inx 12774 29 an an DT cord-010092-uftc8inx 12774 30 emergency emergency NN cord-010092-uftc8inx 12774 31 including include VBG cord-010092-uftc8inx 12774 32 provision provision NN cord-010092-uftc8inx 12774 33 of of IN cord-010092-uftc8inx 12774 34 major major JJ cord-010092-uftc8inx 12774 35 haemorrhage haemorrhage NN cord-010092-uftc8inx 12774 36 protocols protocol NNS cord-010092-uftc8inx 12774 37 ( ( -LRB- cord-010092-uftc8inx 12774 38 MHP MHP NNP cord-010092-uftc8inx 12774 39 ) ) -RRB- cord-010092-uftc8inx 12774 40 and and CC cord-010092-uftc8inx 12774 41 drills drill NNS cord-010092-uftc8inx 12774 42 . . . cord-010092-uftc8inx 12775 1 The the DT cord-010092-uftc8inx 12775 2 National National NNP cord-010092-uftc8inx 12775 3 Reporting Reporting NNP cord-010092-uftc8inx 12775 4 and and CC cord-010092-uftc8inx 12775 5 Learning Learning NNP cord-010092-uftc8inx 12775 6 scheme scheme NN cord-010092-uftc8inx 12775 7 had have VBD cord-010092-uftc8inx 12775 8 identified identify VBN cord-010092-uftc8inx 12775 9 reports report NNS cord-010092-uftc8inx 12775 10 of of IN cord-010092-uftc8inx 12775 11 11 11 CD cord-010092-uftc8inx 12775 12 deaths death NNS cord-010092-uftc8inx 12775 13 and and CC cord-010092-uftc8inx 12775 14 83 83 CD cord-010092-uftc8inx 12775 15 instances instance NNS cord-010092-uftc8inx 12775 16 of of IN cord-010092-uftc8inx 12775 17 harm harm NN cord-010092-uftc8inx 12775 18 due due IN cord-010092-uftc8inx 12775 19 to to TO cord-010092-uftc8inx 12775 20 delay delay VB cord-010092-uftc8inx 12775 21 over over IN cord-010092-uftc8inx 12775 22 a a DT cord-010092-uftc8inx 12775 23 4-year 4-year CD cord-010092-uftc8inx 12775 24 period period NN cord-010092-uftc8inx 12775 25 . . . cord-010092-uftc8inx 12776 1 Aims aim VBZ cord-010092-uftc8inx 12776 2 : : : cord-010092-uftc8inx 12777 1 The the DT cord-010092-uftc8inx 12777 2 aim aim NN cord-010092-uftc8inx 12777 3 of of IN cord-010092-uftc8inx 12777 4 the the DT cord-010092-uftc8inx 12777 5 study study NN cord-010092-uftc8inx 12777 6 was be VBD cord-010092-uftc8inx 12777 7 to to TO cord-010092-uftc8inx 12777 8 monitor monitor VB cord-010092-uftc8inx 12777 9 the the DT cord-010092-uftc8inx 12777 10 acid acid NN cord-010092-uftc8inx 12777 11 - - HYPH cord-010092-uftc8inx 12777 12 base base NN cord-010092-uftc8inx 12777 13 status status NN cord-010092-uftc8inx 12777 14 of of IN cord-010092-uftc8inx 12777 15 the the DT cord-010092-uftc8inx 12777 16 patient patient NN cord-010092-uftc8inx 12777 17 by by IN cord-010092-uftc8inx 12777 18 means mean NNS cord-010092-uftc8inx 12777 19 of of IN cord-010092-uftc8inx 12777 20 ABG ABG NNP cord-010092-uftc8inx 12777 21 and and CC cord-010092-uftc8inx 12777 22 to to TO cord-010092-uftc8inx 12777 23 administer administer VB cord-010092-uftc8inx 12777 24 the the DT cord-010092-uftc8inx 12777 25 blood blood NN cord-010092-uftc8inx 12777 26 component component NN cord-010092-uftc8inx 12777 27 therapy therapy NN cord-010092-uftc8inx 12777 28 based base VBN cord-010092-uftc8inx 12777 29 on on IN cord-010092-uftc8inx 12777 30 TEG TEG NNP cord-010092-uftc8inx 12777 31 results result NNS cord-010092-uftc8inx 12777 32 . . . cord-010092-uftc8inx 12778 1 Methods method NNS cord-010092-uftc8inx 12778 2 : : : cord-010092-uftc8inx 12778 3 This this DT cord-010092-uftc8inx 12778 4 study study NN cord-010092-uftc8inx 12778 5 was be VBD cord-010092-uftc8inx 12778 6 a a DT cord-010092-uftc8inx 12778 7 prospective prospective JJ cord-010092-uftc8inx 12778 8 observational observational JJ cord-010092-uftc8inx 12778 9 study study NN cord-010092-uftc8inx 12778 10 of of IN cord-010092-uftc8inx 12778 11 18 18 CD cord-010092-uftc8inx 12778 12 adult adult NN cord-010092-uftc8inx 12778 13 patients patient NNS cord-010092-uftc8inx 12778 14 over over IN cord-010092-uftc8inx 12778 15 a a DT cord-010092-uftc8inx 12778 16 period period NN cord-010092-uftc8inx 12778 17 of of IN cord-010092-uftc8inx 12778 18 7 7 CD cord-010092-uftc8inx 12778 19 months month NNS cord-010092-uftc8inx 12778 20 . . . cord-010092-uftc8inx 12779 1 Serial serial JJ cord-010092-uftc8inx 12779 2 monitoring monitoring NN cord-010092-uftc8inx 12779 3 of of IN cord-010092-uftc8inx 12779 4 the the DT cord-010092-uftc8inx 12779 5 ABG ABG NNP cord-010092-uftc8inx 12779 6 in in IN cord-010092-uftc8inx 12779 7 the the DT cord-010092-uftc8inx 12779 8 intra intra JJ cord-010092-uftc8inx 12779 9 - - JJ cord-010092-uftc8inx 12779 10 operative operative JJ cord-010092-uftc8inx 12779 11 period period NN cord-010092-uftc8inx 12779 12 was be VBD cord-010092-uftc8inx 12779 13 done do VBN cord-010092-uftc8inx 12779 14 . . . cord-010092-uftc8inx 12780 1 TEG TEG NNP cord-010092-uftc8inx 12780 2 guided guide VBN cord-010092-uftc8inx 12780 3 resuscitation resuscitation NN cord-010092-uftc8inx 12780 4 was be VBD cord-010092-uftc8inx 12780 5 performed perform VBN cord-010092-uftc8inx 12780 6 in in IN cord-010092-uftc8inx 12780 7 all all DT cord-010092-uftc8inx 12780 8 18 18 CD cord-010092-uftc8inx 12780 9 cases case NNS cord-010092-uftc8inx 12780 10 . . . cord-010092-uftc8inx 12781 1 Results result NNS cord-010092-uftc8inx 12781 2 : : : cord-010092-uftc8inx 12782 1 The the DT cord-010092-uftc8inx 12782 2 ABG ABG NNP cord-010092-uftc8inx 12782 3 analysis analysis NN cord-010092-uftc8inx 12782 4 of of IN cord-010092-uftc8inx 12782 5 all all DT cord-010092-uftc8inx 12782 6 18 18 CD cord-010092-uftc8inx 12782 7 patients patient NNS cord-010092-uftc8inx 12782 8 showed show VBD cord-010092-uftc8inx 12782 9 decrease decrease NN cord-010092-uftc8inx 12782 10 in in IN cord-010092-uftc8inx 12782 11 the the DT cord-010092-uftc8inx 12782 12 pH ph NN cord-010092-uftc8inx 12782 13 , , , cord-010092-uftc8inx 12782 14 increase increase VB cord-010092-uftc8inx 12782 15 in in IN cord-010092-uftc8inx 12782 16 pCO pco CD cord-010092-uftc8inx 12782 17 2 2 CD cord-010092-uftc8inx 12782 18 , , , cord-010092-uftc8inx 12782 19 decrease decrease NN cord-010092-uftc8inx 12782 20 in in IN cord-010092-uftc8inx 12782 21 serum serum NN cord-010092-uftc8inx 12782 22 bicarbonate bicarbonate NN cord-010092-uftc8inx 12782 23 level level NN cord-010092-uftc8inx 12782 24 and and CC cord-010092-uftc8inx 12782 25 elevation elevation NN cord-010092-uftc8inx 12782 26 in in IN cord-010092-uftc8inx 12782 27 negative negative JJ cord-010092-uftc8inx 12782 28 base base NN cord-010092-uftc8inx 12782 29 excess excess NN cord-010092-uftc8inx 12782 30 . . . cord-010092-uftc8inx 12783 1 These these DT cord-010092-uftc8inx 12783 2 components component NNS cord-010092-uftc8inx 12783 3 of of IN cord-010092-uftc8inx 12783 4 metabolic metabolic JJ cord-010092-uftc8inx 12783 5 acidosis acidosis NN cord-010092-uftc8inx 12783 6 can can MD cord-010092-uftc8inx 12783 7 be be VB cord-010092-uftc8inx 12783 8 attributed attribute VBN cord-010092-uftc8inx 12783 9 to to IN cord-010092-uftc8inx 12783 10 massive massive JJ cord-010092-uftc8inx 12783 11 transfusion transfusion NN cord-010092-uftc8inx 12783 12 . . . cord-010092-uftc8inx 12784 1 Increased increase VBN cord-010092-uftc8inx 12784 2 lactate lactate NN cord-010092-uftc8inx 12784 3 , , , cord-010092-uftc8inx 12784 4 an an DT cord-010092-uftc8inx 12784 5 independent independent JJ cord-010092-uftc8inx 12784 6 parameter parameter NN cord-010092-uftc8inx 12784 7 , , , cord-010092-uftc8inx 12784 8 which which WDT cord-010092-uftc8inx 12784 9 reflects reflect VBZ cord-010092-uftc8inx 12784 10 poor poor JJ cord-010092-uftc8inx 12784 11 tissue tissue NN cord-010092-uftc8inx 12784 12 perfusion perfusion NN cord-010092-uftc8inx 12784 13 or or CC cord-010092-uftc8inx 12784 14 shock shock NN cord-010092-uftc8inx 12784 15 and and CC cord-010092-uftc8inx 12784 16 predicts predict VBZ cord-010092-uftc8inx 12784 17 need need NN cord-010092-uftc8inx 12784 18 for for IN cord-010092-uftc8inx 12784 19 massive massive JJ cord-010092-uftc8inx 12784 20 transfusion transfusion NN cord-010092-uftc8inx 12784 21 was be VBD cord-010092-uftc8inx 12784 22 observed observe VBN cord-010092-uftc8inx 12784 23 in in IN cord-010092-uftc8inx 12784 24 all all DT cord-010092-uftc8inx 12784 25 patients patient NNS cord-010092-uftc8inx 12784 26 . . . cord-010092-uftc8inx 12785 1 All all PDT cord-010092-uftc8inx 12785 2 the the DT cord-010092-uftc8inx 12785 3 18 18 CD cord-010092-uftc8inx 12785 4 cases case NNS cord-010092-uftc8inx 12785 5 showed show VBD cord-010092-uftc8inx 12785 6 a a DT cord-010092-uftc8inx 12785 7 decrease decrease NN cord-010092-uftc8inx 12785 8 in in IN cord-010092-uftc8inx 12785 9 ionized ionized JJ cord-010092-uftc8inx 12785 10 calcium calcium NN cord-010092-uftc8inx 12785 11 levels level NNS cord-010092-uftc8inx 12785 12 which which WDT cord-010092-uftc8inx 12785 13 could could MD cord-010092-uftc8inx 12785 14 be be VB cord-010092-uftc8inx 12785 15 a a DT cord-010092-uftc8inx 12785 16 result result NN cord-010092-uftc8inx 12785 17 of of IN cord-010092-uftc8inx 12785 18 citrate citrate NN cord-010092-uftc8inx 12785 19 related relate VBN cord-010092-uftc8inx 12785 20 toxicity toxicity NN cord-010092-uftc8inx 12785 21 . . . cord-010092-uftc8inx 12786 1 Increased increase VBN cord-010092-uftc8inx 12786 2 glucose glucose NN cord-010092-uftc8inx 12786 3 was be VBD cord-010092-uftc8inx 12786 4 observed observe VBN cord-010092-uftc8inx 12786 5 in in IN cord-010092-uftc8inx 12786 6 all all DT cord-010092-uftc8inx 12786 7 patients patient NNS cord-010092-uftc8inx 12786 8 which which WDT cord-010092-uftc8inx 12786 9 may may MD cord-010092-uftc8inx 12786 10 be be VB cord-010092-uftc8inx 12786 11 due due JJ cord-010092-uftc8inx 12786 12 to to TO cord-010092-uftc8inx 12786 13 increase increase VB cord-010092-uftc8inx 12786 14 in in IN cord-010092-uftc8inx 12786 15 the the DT cord-010092-uftc8inx 12786 16 catecholamine catecholamine NN cord-010092-uftc8inx 12786 17 release release NN cord-010092-uftc8inx 12786 18 as as IN cord-010092-uftc8inx 12786 19 a a DT cord-010092-uftc8inx 12786 20 response response NN cord-010092-uftc8inx 12786 21 to to IN cord-010092-uftc8inx 12786 22 haemorrhagic haemorrhagic JJ cord-010092-uftc8inx 12786 23 shock shock NN cord-010092-uftc8inx 12786 24 . . . cord-010092-uftc8inx 12787 1 Electrolyte electrolyte NN cord-010092-uftc8inx 12787 2 correction correction NN cord-010092-uftc8inx 12787 3 was be VBD cord-010092-uftc8inx 12787 4 given give VBN cord-010092-uftc8inx 12787 5 depending depend VBG cord-010092-uftc8inx 12787 6 on on IN cord-010092-uftc8inx 12787 7 results result NNS cord-010092-uftc8inx 12787 8 of of IN cord-010092-uftc8inx 12787 9 the the DT cord-010092-uftc8inx 12787 10 ABG ABG NNP cord-010092-uftc8inx 12787 11 analysis analysis NN cord-010092-uftc8inx 12787 12 wherever wherever WRB cord-010092-uftc8inx 12787 13 appropriate appropriate JJ cord-010092-uftc8inx 12787 14 . . . cord-010092-uftc8inx 12788 1 Two two CD cord-010092-uftc8inx 12788 2 out out IN cord-010092-uftc8inx 12788 3 of of IN cord-010092-uftc8inx 12788 4 18 18 CD cord-010092-uftc8inx 12788 5 cases case NNS cord-010092-uftc8inx 12788 6 showed show VBD cord-010092-uftc8inx 12788 7 an an DT cord-010092-uftc8inx 12788 8 increase increase NN cord-010092-uftc8inx 12788 9 in in IN cord-010092-uftc8inx 12788 10 R r NN cord-010092-uftc8inx 12788 11 time time NN cord-010092-uftc8inx 12788 12 indicating indicate VBG cord-010092-uftc8inx 12788 13 deficient deficient JJ cord-010092-uftc8inx 12788 14 coagulation coagulation NN cord-010092-uftc8inx 12788 15 factors factor NNS cord-010092-uftc8inx 12788 16 , , , cord-010092-uftc8inx 12788 17 which which WDT cord-010092-uftc8inx 12788 18 was be VBD cord-010092-uftc8inx 12788 19 corrected correct VBN cord-010092-uftc8inx 12788 20 with with IN cord-010092-uftc8inx 12788 21 Fresh Fresh NNP cord-010092-uftc8inx 12788 22 Frozen Frozen NNP cord-010092-uftc8inx 12788 23 Plasma Plasma NNP cord-010092-uftc8inx 12788 24 ( ( -LRB- cord-010092-uftc8inx 12788 25 FFP FFP NNP cord-010092-uftc8inx 12788 26 ) ) -RRB- cord-010092-uftc8inx 12788 27 . . . cord-010092-uftc8inx 12789 1 Three three CD cord-010092-uftc8inx 12789 2 cases case NNS cord-010092-uftc8inx 12789 3 showed show VBD cord-010092-uftc8inx 12789 4 elevation elevation NN cord-010092-uftc8inx 12789 5 in in IN cord-010092-uftc8inx 12789 6 K K NNP cord-010092-uftc8inx 12789 7 time time NN cord-010092-uftc8inx 12789 8 indicating indicate VBG cord-010092-uftc8inx 12789 9 deficient deficient JJ cord-010092-uftc8inx 12789 10 fibrinogen fibrinogen NN cord-010092-uftc8inx 12789 11 levels level NNS cord-010092-uftc8inx 12789 12 , , , cord-010092-uftc8inx 12789 13 which which WDT cord-010092-uftc8inx 12789 14 was be VBD cord-010092-uftc8inx 12789 15 corrected correct VBN cord-010092-uftc8inx 12789 16 by by IN cord-010092-uftc8inx 12789 17 FFP FFP NNP cord-010092-uftc8inx 12789 18 . . . cord-010092-uftc8inx 12790 1 Fresh fresh JJ cord-010092-uftc8inx 12790 2 frozen frozen JJ cord-010092-uftc8inx 12790 3 plasma plasma NN cord-010092-uftc8inx 12790 4 was be VBD cord-010092-uftc8inx 12790 5 also also RB cord-010092-uftc8inx 12790 6 given give VBN cord-010092-uftc8inx 12790 7 in in IN cord-010092-uftc8inx 12790 8 4 4 CD cord-010092-uftc8inx 12790 9 cases case NNS cord-010092-uftc8inx 12790 10 , , , cord-010092-uftc8inx 12790 11 which which WDT cord-010092-uftc8inx 12790 12 showed show VBD cord-010092-uftc8inx 12790 13 decrease decrease NN cord-010092-uftc8inx 12790 14 in in IN cord-010092-uftc8inx 12790 15 the the DT cord-010092-uftc8inx 12790 16 alpha alpha NN cord-010092-uftc8inx 12790 17 angle angle NN cord-010092-uftc8inx 12790 18 , , , cord-010092-uftc8inx 12790 19 indicating indicate VBG cord-010092-uftc8inx 12790 20 deficient deficient JJ cord-010092-uftc8inx 12790 21 fibrinogen fibrinogen NN cord-010092-uftc8inx 12790 22 , , , cord-010092-uftc8inx 12790 23 and and CC cord-010092-uftc8inx 12790 24 cryoprecipitate cryoprecipitate NNP cord-010092-uftc8inx 12790 25 was be VBD cord-010092-uftc8inx 12790 26 given give VBN cord-010092-uftc8inx 12790 27 in in IN cord-010092-uftc8inx 12790 28 2 2 CD cord-010092-uftc8inx 12790 29 cases case NNS cord-010092-uftc8inx 12790 30 . . . cord-010092-uftc8inx 12791 1 Platelets platelet NNS cord-010092-uftc8inx 12791 2 were be VBD cord-010092-uftc8inx 12791 3 transfused transfuse VBN cord-010092-uftc8inx 12791 4 in in IN cord-010092-uftc8inx 12791 5 5 5 CD cord-010092-uftc8inx 12791 6 patients patient NNS cord-010092-uftc8inx 12791 7 showing show VBG cord-010092-uftc8inx 12791 8 a a DT cord-010092-uftc8inx 12791 9 decrease decrease NN cord-010092-uftc8inx 12791 10 in in IN cord-010092-uftc8inx 12791 11 the the DT cord-010092-uftc8inx 12791 12 Maximum maximum JJ cord-010092-uftc8inx 12791 13 Amplitude amplitude NN cord-010092-uftc8inx 12791 14 ( ( -LRB- cord-010092-uftc8inx 12791 15 MA MA NNP cord-010092-uftc8inx 12791 16 ) ) -RRB- cord-010092-uftc8inx 12791 17 , , , cord-010092-uftc8inx 12791 18 which which WDT cord-010092-uftc8inx 12791 19 indicates indicate VBZ cord-010092-uftc8inx 12791 20 deficient deficient JJ cord-010092-uftc8inx 12791 21 platelets platelet NNS cord-010092-uftc8inx 12791 22 . . . cord-010092-uftc8inx 12792 1 Summary Summary NNP cord-010092-uftc8inx 12792 2 / / SYM cord-010092-uftc8inx 12792 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 12792 4 : : : cord-010092-uftc8inx 12793 1 TEG TEG NNP cord-010092-uftc8inx 12793 2 as as IN cord-010092-uftc8inx 12793 3 POC POC NNP cord-010092-uftc8inx 12793 4 testing testing NN cord-010092-uftc8inx 12793 5 is be VBZ cord-010092-uftc8inx 12793 6 an an DT cord-010092-uftc8inx 12793 7 important important JJ cord-010092-uftc8inx 12793 8 tool tool NN cord-010092-uftc8inx 12793 9 in in IN cord-010092-uftc8inx 12793 10 appropriate appropriate JJ cord-010092-uftc8inx 12793 11 blood blood NN cord-010092-uftc8inx 12793 12 component component NN cord-010092-uftc8inx 12793 13 therapy therapy NN cord-010092-uftc8inx 12793 14 in in IN cord-010092-uftc8inx 12793 15 massive massive JJ cord-010092-uftc8inx 12793 16 transfusions transfusion NNS cord-010092-uftc8inx 12793 17 . . . cord-010092-uftc8inx 12794 1 Serial serial JJ cord-010092-uftc8inx 12794 2 monitoring monitoring NN cord-010092-uftc8inx 12794 3 of of IN cord-010092-uftc8inx 12794 4 ABG ABG NNP cord-010092-uftc8inx 12794 5 helps help VBZ cord-010092-uftc8inx 12794 6 in in IN cord-010092-uftc8inx 12794 7 monitoring monitor VBG cord-010092-uftc8inx 12794 8 acid acid NN cord-010092-uftc8inx 12794 9 - - HYPH cord-010092-uftc8inx 12794 10 base base NN cord-010092-uftc8inx 12794 11 status status NN cord-010092-uftc8inx 12794 12 of of IN cord-010092-uftc8inx 12794 13 the the DT cord-010092-uftc8inx 12794 14 patient patient NN cord-010092-uftc8inx 12794 15 and and CC cord-010092-uftc8inx 12794 16 therefore therefore RB cord-010092-uftc8inx 12794 17 is be VBZ cord-010092-uftc8inx 12794 18 a a DT cord-010092-uftc8inx 12794 19 guide guide NN cord-010092-uftc8inx 12794 20 in in IN cord-010092-uftc8inx 12794 21 the the DT cord-010092-uftc8inx 12794 22 correcting correct VBG cord-010092-uftc8inx 12794 23 electrolyte electrolyte JJ cord-010092-uftc8inx 12794 24 level level NN cord-010092-uftc8inx 12794 25 in in IN cord-010092-uftc8inx 12794 26 patients patient NNS cord-010092-uftc8inx 12794 27 undergoing undergo VBG cord-010092-uftc8inx 12794 28 massive massive JJ cord-010092-uftc8inx 12794 29 transfusion transfusion NN cord-010092-uftc8inx 12794 30 . . . cord-010092-uftc8inx 12795 1 Background background NN cord-010092-uftc8inx 12795 2 : : : cord-010092-uftc8inx 12796 1 Massive massive JJ cord-010092-uftc8inx 12796 2 blood blood NN cord-010092-uftc8inx 12796 3 loss loss NN cord-010092-uftc8inx 12796 4 is be VBZ cord-010092-uftc8inx 12796 5 encountered encounter VBN cord-010092-uftc8inx 12796 6 in in IN cord-010092-uftc8inx 12796 7 various various JJ cord-010092-uftc8inx 12796 8 situations situation NNS cord-010092-uftc8inx 12796 9 like like IN cord-010092-uftc8inx 12796 10 trauma trauma NN cord-010092-uftc8inx 12796 11 , , , cord-010092-uftc8inx 12796 12 major major JJ cord-010092-uftc8inx 12796 13 surgeries surgery NNS cord-010092-uftc8inx 12796 14 , , , cord-010092-uftc8inx 12796 15 gastrointestinal gastrointestinal JJ cord-010092-uftc8inx 12796 16 bleeds bleed NNS cord-010092-uftc8inx 12796 17 and and CC cord-010092-uftc8inx 12796 18 obstetric obstetric JJ cord-010092-uftc8inx 12796 19 haemorrhages haemorrhage NNS cord-010092-uftc8inx 12796 20 . . . cord-010092-uftc8inx 12797 1 Haemorrhage Haemorrhage NNP cord-010092-uftc8inx 12797 2 is be VBZ cord-010092-uftc8inx 12797 3 an an DT cord-010092-uftc8inx 12797 4 important important JJ cord-010092-uftc8inx 12797 5 cause cause NN cord-010092-uftc8inx 12797 6 of of IN cord-010092-uftc8inx 12797 7 mortality mortality NN cord-010092-uftc8inx 12797 8 and and CC cord-010092-uftc8inx 12797 9 morbidity morbidity NN cord-010092-uftc8inx 12797 10 in in IN cord-010092-uftc8inx 12797 11 massively massively RB cord-010092-uftc8inx 12797 12 bleeding bleed VBG cord-010092-uftc8inx 12797 13 patients patient NNS cord-010092-uftc8inx 12797 14 . . . cord-010092-uftc8inx 12798 1 Early early JJ cord-010092-uftc8inx 12798 2 recognition recognition NN cord-010092-uftc8inx 12798 3 of of IN cord-010092-uftc8inx 12798 4 haemorrhage haemorrhage NN cord-010092-uftc8inx 12798 5 and and CC cord-010092-uftc8inx 12798 6 intervention intervention NN cord-010092-uftc8inx 12798 7 is be VBZ cord-010092-uftc8inx 12798 8 essential essential JJ cord-010092-uftc8inx 12798 9 for for IN cord-010092-uftc8inx 12798 10 survival survival NN cord-010092-uftc8inx 12798 11 . . . cord-010092-uftc8inx 12799 1 Massive massive JJ cord-010092-uftc8inx 12799 2 transfusion transfusion NN cord-010092-uftc8inx 12799 3 ( ( -LRB- cord-010092-uftc8inx 12799 4 MT MT NNP cord-010092-uftc8inx 12799 5 ) ) -RRB- cord-010092-uftc8inx 12799 6 of of IN cord-010092-uftc8inx 12799 7 blood blood NN cord-010092-uftc8inx 12799 8 is be VBZ cord-010092-uftc8inx 12799 9 required require VBN cord-010092-uftc8inx 12799 10 to to TO cord-010092-uftc8inx 12799 11 replenish replenish VB cord-010092-uftc8inx 12799 12 blood blood NN cord-010092-uftc8inx 12799 13 losses loss NNS cord-010092-uftc8inx 12799 14 and and CC cord-010092-uftc8inx 12799 15 is be VBZ cord-010092-uftc8inx 12799 16 a a DT cord-010092-uftc8inx 12799 17 lifesaving lifesaving JJ cord-010092-uftc8inx 12799 18 treatment treatment NN cord-010092-uftc8inx 12799 19 in in IN cord-010092-uftc8inx 12799 20 these these DT cord-010092-uftc8inx 12799 21 patients patient NNS cord-010092-uftc8inx 12799 22 . . . cord-010092-uftc8inx 12800 1 A a DT cord-010092-uftc8inx 12800 2 variety variety NN cord-010092-uftc8inx 12800 3 of of IN cord-010092-uftc8inx 12800 4 haemostasis haemostasis NN cord-010092-uftc8inx 12800 5 and and CC cord-010092-uftc8inx 12800 6 pathophysiological pathophysiological JJ cord-010092-uftc8inx 12800 7 changes change NNS cord-010092-uftc8inx 12800 8 occur occur VBP cord-010092-uftc8inx 12800 9 during during IN cord-010092-uftc8inx 12800 10 massive massive JJ cord-010092-uftc8inx 12800 11 haemorrhage haemorrhage NN cord-010092-uftc8inx 12800 12 and and CC cord-010092-uftc8inx 12800 13 massive massive JJ cord-010092-uftc8inx 12800 14 transfusion transfusion NN cord-010092-uftc8inx 12800 15 . . . cord-010092-uftc8inx 12801 1 All all DT cord-010092-uftc8inx 12801 2 of of IN cord-010092-uftc8inx 12801 3 these these DT cord-010092-uftc8inx 12801 4 changes change NNS cord-010092-uftc8inx 12801 5 contribute contribute VBP cord-010092-uftc8inx 12801 6 to to IN cord-010092-uftc8inx 12801 7 the the DT cord-010092-uftc8inx 12801 8 vicious vicious JJ cord-010092-uftc8inx 12801 9 cycle cycle NN cord-010092-uftc8inx 12801 10 of of IN cord-010092-uftc8inx 12801 11 progressive progressive JJ cord-010092-uftc8inx 12801 12 coagulopathy coagulopathy NN cord-010092-uftc8inx 12801 13 due due IN cord-010092-uftc8inx 12801 14 to to IN cord-010092-uftc8inx 12801 15 the the DT cord-010092-uftc8inx 12801 16 ' ' `` cord-010092-uftc8inx 12801 17 lethal lethal JJ cord-010092-uftc8inx 12801 18 triad triad NN cord-010092-uftc8inx 12801 19 ' ' '' cord-010092-uftc8inx 12801 20 of of IN cord-010092-uftc8inx 12801 21 refractory refractory JJ cord-010092-uftc8inx 12801 22 coagulopathy coagulopathy NN cord-010092-uftc8inx 12801 23 , , , cord-010092-uftc8inx 12801 24 progressive progressive JJ cord-010092-uftc8inx 12801 25 hypothermia hypothermia NN cord-010092-uftc8inx 12801 26 and and CC cord-010092-uftc8inx 12801 27 persistent persistent JJ cord-010092-uftc8inx 12801 28 metabolic metabolic JJ cord-010092-uftc8inx 12801 29 acidosis acidosis NN cord-010092-uftc8inx 12801 30 . . . cord-010092-uftc8inx 12802 1 Aims aim VBZ cord-010092-uftc8inx 12802 2 : : : cord-010092-uftc8inx 12803 1 The the DT cord-010092-uftc8inx 12803 2 aims aim NNS cord-010092-uftc8inx 12803 3 of of IN cord-010092-uftc8inx 12803 4 the the DT cord-010092-uftc8inx 12803 5 study study NN cord-010092-uftc8inx 12803 6 included include VBD cord-010092-uftc8inx 12803 7 understanding understanding NN cord-010092-uftc8inx 12803 8 management management NN cord-010092-uftc8inx 12803 9 of of IN cord-010092-uftc8inx 12803 10 cases case NNS cord-010092-uftc8inx 12803 11 of of IN cord-010092-uftc8inx 12803 12 massive massive JJ cord-010092-uftc8inx 12803 13 blood blood NN cord-010092-uftc8inx 12803 14 transfusion transfusion NN cord-010092-uftc8inx 12803 15 in in IN cord-010092-uftc8inx 12803 16 surgical surgical JJ cord-010092-uftc8inx 12803 17 patients patient NNS cord-010092-uftc8inx 12803 18 , , , cord-010092-uftc8inx 12803 19 impact impact NN cord-010092-uftc8inx 12803 20 of of IN cord-010092-uftc8inx 12803 21 MT MT NNP cord-010092-uftc8inx 12803 22 of of IN cord-010092-uftc8inx 12803 23 blood blood NN cord-010092-uftc8inx 12803 24 components component NNS cord-010092-uftc8inx 12803 25 on on IN cord-010092-uftc8inx 12803 26 patient patient JJ cord-010092-uftc8inx 12803 27 outcome outcome NN cord-010092-uftc8inx 12803 28 , , , cord-010092-uftc8inx 12803 29 evaluating evaluate VBG cord-010092-uftc8inx 12803 30 post post JJ cord-010092-uftc8inx 12803 31 - - JJ cord-010092-uftc8inx 12803 32 operative operative JJ cord-010092-uftc8inx 12803 33 complications complication NNS cord-010092-uftc8inx 12803 34 of of IN cord-010092-uftc8inx 12803 35 massive massive JJ cord-010092-uftc8inx 12803 36 transfusion transfusion NN cord-010092-uftc8inx 12803 37 and and CC cord-010092-uftc8inx 12803 38 the the DT cord-010092-uftc8inx 12803 39 development development NN cord-010092-uftc8inx 12803 40 of of IN cord-010092-uftc8inx 12803 41 institutional institutional JJ cord-010092-uftc8inx 12803 42 Massive Massive NNP cord-010092-uftc8inx 12803 43 Transfusion Transfusion NNP cord-010092-uftc8inx 12803 44 Protocol Protocol NNP cord-010092-uftc8inx 12803 45 ( ( -LRB- cord-010092-uftc8inx 12803 46 MTP).Methods mtp).method NNS cord-010092-uftc8inx 12803 47 : : : cord-010092-uftc8inx 12804 1 This this DT cord-010092-uftc8inx 12804 2 prospective prospective JJ cord-010092-uftc8inx 12804 3 observational observational JJ cord-010092-uftc8inx 12804 4 study study NN cord-010092-uftc8inx 12804 5 commenced commence VBN cord-010092-uftc8inx 12804 6 after after IN cord-010092-uftc8inx 12804 7 Institutional Institutional NNP cord-010092-uftc8inx 12804 8 Ethics Ethics NNP cord-010092-uftc8inx 12804 9 Committee Committee NNP cord-010092-uftc8inx 12804 10 ( ( -LRB- cord-010092-uftc8inx 12804 11 IEC IEC NNP cord-010092-uftc8inx 12804 12 ) ) -RRB- cord-010092-uftc8inx 12804 13 approval approval NN cord-010092-uftc8inx 12804 14 . . . cord-010092-uftc8inx 12805 1 It -PRON- PRP cord-010092-uftc8inx 12805 2 comprised comprise VBD cord-010092-uftc8inx 12805 3 of of IN cord-010092-uftc8inx 12805 4 40 40 CD cord-010092-uftc8inx 12805 5 adult adult NN cord-010092-uftc8inx 12805 6 surgical surgical JJ cord-010092-uftc8inx 12805 7 oncology oncology NN cord-010092-uftc8inx 12805 8 patients patient NNS cord-010092-uftc8inx 12805 9 who who WP cord-010092-uftc8inx 12805 10 received receive VBD cord-010092-uftc8inx 12805 11 massive massive JJ cord-010092-uftc8inx 12805 12 transfusions transfusion NNS cord-010092-uftc8inx 12805 13 and and CC cord-010092-uftc8inx 12805 14 was be VBD cord-010092-uftc8inx 12805 15 conducted conduct VBN cord-010092-uftc8inx 12805 16 for for IN cord-010092-uftc8inx 12805 17 a a DT cord-010092-uftc8inx 12805 18 period period NN cord-010092-uftc8inx 12805 19 of of IN cord-010092-uftc8inx 12805 20 7 7 CD cord-010092-uftc8inx 12805 21 months month NNS cord-010092-uftc8inx 12805 22 . . . cord-010092-uftc8inx 12806 1 Every every DT cord-010092-uftc8inx 12806 2 case case NN cord-010092-uftc8inx 12806 3 of of IN cord-010092-uftc8inx 12806 4 a a DT cord-010092-uftc8inx 12806 5 massive massive JJ cord-010092-uftc8inx 12806 6 transfusion transfusion NN cord-010092-uftc8inx 12806 7 was be VBD cord-010092-uftc8inx 12806 8 studied study VBN cord-010092-uftc8inx 12806 9 under under IN cord-010092-uftc8inx 12806 10 the the DT cord-010092-uftc8inx 12806 11 following follow VBG cord-010092-uftc8inx 12806 12 headings heading NNS cord-010092-uftc8inx 12806 13 ( ( -LRB- cord-010092-uftc8inx 12806 14 1 1 CD cord-010092-uftc8inx 12806 15 ) ) -RRB- cord-010092-uftc8inx 12806 16 Patient Patient NNP cord-010092-uftc8inx 12806 17 's 's POS cord-010092-uftc8inx 12806 18 details detail NNS cord-010092-uftc8inx 12806 19 ( ( -LRB- cord-010092-uftc8inx 12806 20 2 2 CD cord-010092-uftc8inx 12806 21 ) ) -RRB- cord-010092-uftc8inx 12806 22 Patients patient NNS cord-010092-uftc8inx 12806 23 base base NN cord-010092-uftc8inx 12806 24 - - HYPH cord-010092-uftc8inx 12806 25 line line NN cord-010092-uftc8inx 12806 26 laboratory laboratory NN cord-010092-uftc8inx 12806 27 tests test NNS cord-010092-uftc8inx 12806 28 ( ( -LRB- cord-010092-uftc8inx 12806 29 3 3 LS cord-010092-uftc8inx 12806 30 ) ) -RRB- cord-010092-uftc8inx 12806 31 Resuscitation resuscitation NN cord-010092-uftc8inx 12806 32 with with IN cord-010092-uftc8inx 12806 33 transfusion transfusion NN cord-010092-uftc8inx 12806 34 ( ( -LRB- cord-010092-uftc8inx 12806 35 4 4 CD cord-010092-uftc8inx 12806 36 ) ) -RRB- cord-010092-uftc8inx 12806 37 Intra intra JJ cord-010092-uftc8inx 12806 38 - - JJ cord-010092-uftc8inx 12806 39 operative operative JJ cord-010092-uftc8inx 12806 40 laboratory laboratory NN cord-010092-uftc8inx 12806 41 tests test NNS cord-010092-uftc8inx 12806 42 ( ( -LRB- cord-010092-uftc8inx 12806 43 5 5 LS cord-010092-uftc8inx 12806 44 ) ) -RRB- cord-010092-uftc8inx 12806 45 Thromboelastography Thromboelastography NNP cord-010092-uftc8inx 12806 46 ( ( -LRB- cord-010092-uftc8inx 12806 47 TEG TEG NNP cord-010092-uftc8inx 12806 48 ) ) -RRB- cord-010092-uftc8inx 12806 49 ( ( -LRB- cord-010092-uftc8inx 12806 50 6 6 LS cord-010092-uftc8inx 12806 51 ) ) -RRB- cord-010092-uftc8inx 12806 52 Post post JJ cord-010092-uftc8inx 12806 53 - - JJ cord-010092-uftc8inx 12806 54 operative operative JJ cord-010092-uftc8inx 12806 55 complications complication NNS cord-010092-uftc8inx 12806 56 ( ( -LRB- cord-010092-uftc8inx 12806 57 7 7 CD cord-010092-uftc8inx 12806 58 ) ) -RRB- cord-010092-uftc8inx 12806 59 Duration duration NN cord-010092-uftc8inx 12806 60 of of IN cord-010092-uftc8inx 12806 61 stay stay NN cord-010092-uftc8inx 12806 62 in in IN cord-010092-uftc8inx 12806 63 the the DT cord-010092-uftc8inx 12806 64 hospital hospital NN cord-010092-uftc8inx 12806 65 ( ( -LRB- cord-010092-uftc8inx 12806 66 8) 8) NNP cord-010092-uftc8inx 12806 67 30 30 CD cord-010092-uftc8inx 12806 68 day day NN cord-010092-uftc8inx 12806 69 mortality mortality NN cord-010092-uftc8inx 12806 70 rate rate NN cord-010092-uftc8inx 12806 71 . . . cord-010092-uftc8inx 12807 1 Results result NNS cord-010092-uftc8inx 12807 2 : : : cord-010092-uftc8inx 12808 1 Complete complete JJ cord-010092-uftc8inx 12808 2 blood blood NN cord-010092-uftc8inx 12808 3 count count NN cord-010092-uftc8inx 12808 4 , , , cord-010092-uftc8inx 12808 5 serum serum NN cord-010092-uftc8inx 12808 6 electrolytes electrolyte NNS cord-010092-uftc8inx 12808 7 , , , cord-010092-uftc8inx 12808 8 arterial arterial JJ cord-010092-uftc8inx 12808 9 blood blood NN cord-010092-uftc8inx 12808 10 gases gas NNS cord-010092-uftc8inx 12808 11 , , , cord-010092-uftc8inx 12808 12 coagulation coagulation NN cord-010092-uftc8inx 12808 13 profile profile NN cord-010092-uftc8inx 12808 14 and and CC cord-010092-uftc8inx 12808 15 TEG TEG NNP cord-010092-uftc8inx 12808 16 were be VBD cord-010092-uftc8inx 12808 17 used use VBN cord-010092-uftc8inx 12808 18 to to TO cord-010092-uftc8inx 12808 19 monitor monitor VB cord-010092-uftc8inx 12808 20 transfusion transfusion NN cord-010092-uftc8inx 12808 21 therapy therapy NN cord-010092-uftc8inx 12808 22 in in IN cord-010092-uftc8inx 12808 23 the the DT cord-010092-uftc8inx 12808 24 intraoperative intraoperative JJ cord-010092-uftc8inx 12808 25 period period NN cord-010092-uftc8inx 12808 26 . . . cord-010092-uftc8inx 12809 1 Intraoperative intraoperative JJ cord-010092-uftc8inx 12809 2 laboratory laboratory NN cord-010092-uftc8inx 12809 3 parameters parameter NNS cord-010092-uftc8inx 12809 4 of of IN cord-010092-uftc8inx 12809 5 patients patient NNS cord-010092-uftc8inx 12809 6 showed show VBD cord-010092-uftc8inx 12809 7 dilutional dilutional JJ cord-010092-uftc8inx 12809 8 coagulopathy coagulopathy NN cord-010092-uftc8inx 12809 9 , , , cord-010092-uftc8inx 12809 10 metabolic metabolic JJ cord-010092-uftc8inx 12809 11 acidosis acidosis NN cord-010092-uftc8inx 12809 12 , , , cord-010092-uftc8inx 12809 13 hypocalcaemia hypocalcaemia NNP cord-010092-uftc8inx 12809 14 , , , cord-010092-uftc8inx 12809 15 hypomagnesaemia hypomagnesaemia NNP cord-010092-uftc8inx 12809 16 , , , cord-010092-uftc8inx 12809 17 hyperkalaemia hyperkalaemia NNP cord-010092-uftc8inx 12809 18 and and CC cord-010092-uftc8inx 12809 19 hypokalaemia hypokalaemia NNP cord-010092-uftc8inx 12809 20 , , , cord-010092-uftc8inx 12809 21 increased increase VBN cord-010092-uftc8inx 12809 22 lactates lactate NNS cord-010092-uftc8inx 12809 23 and and CC cord-010092-uftc8inx 12809 24 glucose glucose NN cord-010092-uftc8inx 12809 25 . . . cord-010092-uftc8inx 12810 1 Electrolyte electrolyte NN cord-010092-uftc8inx 12810 2 correction correction NN cord-010092-uftc8inx 12810 3 was be VBD cord-010092-uftc8inx 12810 4 done do VBN cord-010092-uftc8inx 12810 5 based base VBN cord-010092-uftc8inx 12810 6 on on IN cord-010092-uftc8inx 12810 7 the the DT cord-010092-uftc8inx 12810 8 derangement derangement NN cord-010092-uftc8inx 12810 9 . . . cord-010092-uftc8inx 12811 1 The the DT cord-010092-uftc8inx 12811 2 derangements derangement NNS cord-010092-uftc8inx 12811 3 were be VBD cord-010092-uftc8inx 12811 4 on on IN cord-010092-uftc8inx 12811 5 a a DT cord-010092-uftc8inx 12811 6 decreasing decrease VBG cord-010092-uftc8inx 12811 7 trend trend NN cord-010092-uftc8inx 12811 8 in in IN cord-010092-uftc8inx 12811 9 the the DT cord-010092-uftc8inx 12811 10 postoperative postoperative JJ cord-010092-uftc8inx 12811 11 period period NN cord-010092-uftc8inx 12811 12 and and CC cord-010092-uftc8inx 12811 13 returned return VBD cord-010092-uftc8inx 12811 14 to to IN cord-010092-uftc8inx 12811 15 baseline baseline JJ cord-010092-uftc8inx 12811 16 level level NN cord-010092-uftc8inx 12811 17 by by IN cord-010092-uftc8inx 12811 18 2 2 CD cord-010092-uftc8inx 12811 19 nd nd NNP cord-010092-uftc8inx 12811 20 or or CC cord-010092-uftc8inx 12811 21 3 3 CD cord-010092-uftc8inx 12811 22 rd rd NNP cord-010092-uftc8inx 12811 23 post post JJ cord-010092-uftc8inx 12811 24 - - JJ cord-010092-uftc8inx 12811 25 operative operative JJ cord-010092-uftc8inx 12811 26 day day NN cord-010092-uftc8inx 12811 27 with with IN cord-010092-uftc8inx 12811 28 no no DT cord-010092-uftc8inx 12811 29 requirement requirement NN cord-010092-uftc8inx 12811 30 of of IN cord-010092-uftc8inx 12811 31 correction correction NN cord-010092-uftc8inx 12811 32 in in IN cord-010092-uftc8inx 12811 33 the the DT cord-010092-uftc8inx 12811 34 post post JJ cord-010092-uftc8inx 12811 35 - - JJ cord-010092-uftc8inx 12811 36 operative operative JJ cord-010092-uftc8inx 12811 37 period period NN cord-010092-uftc8inx 12811 38 . . . cord-010092-uftc8inx 12812 1 The the DT cord-010092-uftc8inx 12812 2 post post JJ cord-010092-uftc8inx 12812 3 - - JJ cord-010092-uftc8inx 12812 4 operative operative JJ cord-010092-uftc8inx 12812 5 outcomes outcome NNS cord-010092-uftc8inx 12812 6 were be VBD cord-010092-uftc8inx 12812 7 evaluated evaluate VBN cord-010092-uftc8inx 12812 8 in in IN cord-010092-uftc8inx 12812 9 terms term NNS cord-010092-uftc8inx 12812 10 of of IN cord-010092-uftc8inx 12812 11 the the DT cord-010092-uftc8inx 12812 12 Surgical surgical JJ cord-010092-uftc8inx 12812 13 Site site NN cord-010092-uftc8inx 12812 14 Infection infection NN cord-010092-uftc8inx 12812 15 ( ( -LRB- cord-010092-uftc8inx 12812 16 SSI SSI NNP cord-010092-uftc8inx 12812 17 ) ) -RRB- cord-010092-uftc8inx 12812 18 as as IN cord-010092-uftc8inx 12812 19 per per IN cord-010092-uftc8inx 12812 20 the the DT cord-010092-uftc8inx 12812 21 Centers Centers NNPS cord-010092-uftc8inx 12812 22 for for IN cord-010092-uftc8inx 12812 23 Disease Disease NNP cord-010092-uftc8inx 12812 24 Control Control NNP cord-010092-uftc8inx 12812 25 ( ( -LRB- cord-010092-uftc8inx 12812 26 CDC CDC NNP cord-010092-uftc8inx 12812 27 ) ) -RRB- cord-010092-uftc8inx 12812 28 criteria criterion NNS cord-010092-uftc8inx 12812 29 , , , cord-010092-uftc8inx 12812 30 surgical surgical JJ cord-010092-uftc8inx 12812 31 complications complication NNS cord-010092-uftc8inx 12812 32 as as IN cord-010092-uftc8inx 12812 33 per per IN cord-010092-uftc8inx 12812 34 modified modify VBN cord-010092-uftc8inx 12812 35 Clavien Clavien NNP cord-010092-uftc8inx 12812 36 - - HYPH cord-010092-uftc8inx 12812 37 Dindo Dindo NNP cord-010092-uftc8inx 12812 38 classification classification NN cord-010092-uftc8inx 12812 39 and and CC cord-010092-uftc8inx 12812 40 respiratory respiratory JJ cord-010092-uftc8inx 12812 41 complications complication NNS cord-010092-uftc8inx 12812 42 . . . cord-010092-uftc8inx 12813 1 A a DT cord-010092-uftc8inx 12813 2 total total NN cord-010092-uftc8inx 12813 3 of of IN cord-010092-uftc8inx 12813 4 13 13 CD cord-010092-uftc8inx 12813 5 ( ( -LRB- cord-010092-uftc8inx 12813 6 32.5 32.5 CD cord-010092-uftc8inx 12813 7 % % NN cord-010092-uftc8inx 12813 8 ) ) -RRB- cord-010092-uftc8inx 12813 9 patients patient NNS cord-010092-uftc8inx 12813 10 had have VBD cord-010092-uftc8inx 12813 11 SSI SSI NNP cord-010092-uftc8inx 12813 12 , , , cord-010092-uftc8inx 12813 13 14 14 CD cord-010092-uftc8inx 12813 14 ( ( -LRB- cord-010092-uftc8inx 12813 15 35 35 CD cord-010092-uftc8inx 12813 16 % % NN cord-010092-uftc8inx 12813 17 ) ) -RRB- cord-010092-uftc8inx 12813 18 had have VBD cord-010092-uftc8inx 12813 19 surgical surgical JJ cord-010092-uftc8inx 12813 20 complications complication NNS cord-010092-uftc8inx 12813 21 and and CC cord-010092-uftc8inx 12813 22 22 22 CD cord-010092-uftc8inx 12813 23 ( ( -LRB- cord-010092-uftc8inx 12813 24 55 55 CD cord-010092-uftc8inx 12813 25 % % NN cord-010092-uftc8inx 12813 26 ) ) -RRB- cord-010092-uftc8inx 12813 27 patients patient NNS cord-010092-uftc8inx 12813 28 had have VBD cord-010092-uftc8inx 12813 29 respiratory respiratory JJ cord-010092-uftc8inx 12813 30 complications complication NNS cord-010092-uftc8inx 12813 31 . . . cord-010092-uftc8inx 12814 1 The the DT cord-010092-uftc8inx 12814 2 length length NN cord-010092-uftc8inx 12814 3 of of IN cord-010092-uftc8inx 12814 4 the the DT cord-010092-uftc8inx 12814 5 stay stay NN cord-010092-uftc8inx 12814 6 in in IN cord-010092-uftc8inx 12814 7 the the DT cord-010092-uftc8inx 12814 8 hospital hospital NN cord-010092-uftc8inx 12814 9 was be VBD cord-010092-uftc8inx 12814 10 longer long JJR cord-010092-uftc8inx 12814 11 for for IN cord-010092-uftc8inx 12814 12 patients patient NNS cord-010092-uftc8inx 12814 13 who who WP cord-010092-uftc8inx 12814 14 had have VBD cord-010092-uftc8inx 12814 15 postoperative postoperative JJ cord-010092-uftc8inx 12814 16 complications complication NNS cord-010092-uftc8inx 12814 17 . . . cord-010092-uftc8inx 12815 1 Despite despite IN cord-010092-uftc8inx 12815 2 complications complication NNS cord-010092-uftc8inx 12815 3 , , , cord-010092-uftc8inx 12815 4 owing owe VBG cord-010092-uftc8inx 12815 5 to to IN cord-010092-uftc8inx 12815 6 excellent excellent JJ cord-010092-uftc8inx 12815 7 peri peri JJ cord-010092-uftc8inx 12815 8 - - HYPH cord-010092-uftc8inx 12815 9 operative operative JJ cord-010092-uftc8inx 12815 10 care care NN cord-010092-uftc8inx 12815 11 , , , cord-010092-uftc8inx 12815 12 38 38 CD cord-010092-uftc8inx 12815 13 ( ( -LRB- cord-010092-uftc8inx 12815 14 95 95 CD cord-010092-uftc8inx 12815 15 % % NN cord-010092-uftc8inx 12815 16 ) ) -RRB- cord-010092-uftc8inx 12815 17 patients patient NNS cord-010092-uftc8inx 12815 18 were be VBD cord-010092-uftc8inx 12815 19 discharged discharge VBN cord-010092-uftc8inx 12815 20 alive alive JJ cord-010092-uftc8inx 12815 21 . . . cord-010092-uftc8inx 12816 1 Summary Summary NNP cord-010092-uftc8inx 12816 2 / / SYM cord-010092-uftc8inx 12816 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 12816 4 : : : cord-010092-uftc8inx 12817 1 Surgeries surgery NNS cord-010092-uftc8inx 12817 2 associated associate VBN cord-010092-uftc8inx 12817 3 with with IN cord-010092-uftc8inx 12817 4 massive massive JJ cord-010092-uftc8inx 12817 5 transfusion transfusion NN cord-010092-uftc8inx 12817 6 are be VBP cord-010092-uftc8inx 12817 7 at at IN cord-010092-uftc8inx 12817 8 an an DT cord-010092-uftc8inx 12817 9 increased increase VBN cord-010092-uftc8inx 12817 10 risk risk NN cord-010092-uftc8inx 12817 11 of of IN cord-010092-uftc8inx 12817 12 SSI SSI NNP cord-010092-uftc8inx 12817 13 as as RB cord-010092-uftc8inx 12817 14 well well RB cord-010092-uftc8inx 12817 15 as as IN cord-010092-uftc8inx 12817 16 morbidity morbidity NN cord-010092-uftc8inx 12817 17 and and CC cord-010092-uftc8inx 12817 18 mortality mortality NN cord-010092-uftc8inx 12817 19 . . . cord-010092-uftc8inx 12818 1 Complications complication NNS cord-010092-uftc8inx 12818 2 associated associate VBN cord-010092-uftc8inx 12818 3 with with IN cord-010092-uftc8inx 12818 4 rapid rapid JJ cord-010092-uftc8inx 12818 5 transfusions transfusion NNS cord-010092-uftc8inx 12818 6 of of IN cord-010092-uftc8inx 12818 7 blood blood NN cord-010092-uftc8inx 12818 8 , , , cord-010092-uftc8inx 12818 9 acute acute JJ cord-010092-uftc8inx 12818 10 haemorrhage haemorrhage NN cord-010092-uftc8inx 12818 11 and and CC cord-010092-uftc8inx 12818 12 associated associated JJ cord-010092-uftc8inx 12818 13 risk risk NN cord-010092-uftc8inx 12818 14 of of IN cord-010092-uftc8inx 12818 15 the the DT cord-010092-uftc8inx 12818 16 surgery surgery NN cord-010092-uftc8inx 12818 17 lead lead NN cord-010092-uftc8inx 12818 18 to to IN cord-010092-uftc8inx 12818 19 a a DT cord-010092-uftc8inx 12818 20 prolonged prolong VBN cord-010092-uftc8inx 12818 21 ICU ICU NNP cord-010092-uftc8inx 12818 22 stay stay NN cord-010092-uftc8inx 12818 23 and and CC cord-010092-uftc8inx 12818 24 increased increase VBN cord-010092-uftc8inx 12818 25 length length NN cord-010092-uftc8inx 12818 26 of of IN cord-010092-uftc8inx 12818 27 stay stay NN cord-010092-uftc8inx 12818 28 in in IN cord-010092-uftc8inx 12818 29 the the DT cord-010092-uftc8inx 12818 30 hospital hospital NN cord-010092-uftc8inx 12818 31 . . . cord-010092-uftc8inx 12819 1 A a DT cord-010092-uftc8inx 12819 2 well well RB cord-010092-uftc8inx 12819 3 - - HYPH cord-010092-uftc8inx 12819 4 developed develop VBN cord-010092-uftc8inx 12819 5 Massive Massive NNP cord-010092-uftc8inx 12819 6 Transfusion Transfusion NNP cord-010092-uftc8inx 12819 7 Protocol Protocol NNP cord-010092-uftc8inx 12819 8 optimizing optimize VBG cord-010092-uftc8inx 12819 9 the the DT cord-010092-uftc8inx 12819 10 ratio ratio NN cord-010092-uftc8inx 12819 11 and and CC cord-010092-uftc8inx 12819 12 dose dose NN cord-010092-uftc8inx 12819 13 of of IN cord-010092-uftc8inx 12819 14 the the DT cord-010092-uftc8inx 12819 15 blood blood NN cord-010092-uftc8inx 12819 16 component component NN cord-010092-uftc8inx 12819 17 therapy therapy NN cord-010092-uftc8inx 12819 18 results result NNS cord-010092-uftc8inx 12819 19 in in IN cord-010092-uftc8inx 12819 20 excellent excellent JJ cord-010092-uftc8inx 12819 21 patient patient NN cord-010092-uftc8inx 12819 22 outcome outcome NN cord-010092-uftc8inx 12819 23 with with IN cord-010092-uftc8inx 12819 24 minimal minimal JJ cord-010092-uftc8inx 12819 25 postoperative postoperative JJ cord-010092-uftc8inx 12819 26 morbidity morbidity NN cord-010092-uftc8inx 12819 27 and and CC cord-010092-uftc8inx 12819 28 mortality mortality NN cord-010092-uftc8inx 12819 29 . . . cord-010092-uftc8inx 12820 1 Background background NN cord-010092-uftc8inx 12820 2 : : : cord-010092-uftc8inx 12821 1 Despite despite IN cord-010092-uftc8inx 12821 2 the the DT cord-010092-uftc8inx 12821 3 introduction introduction NN cord-010092-uftc8inx 12821 4 of of IN cord-010092-uftc8inx 12821 5 new new JJ cord-010092-uftc8inx 12821 6 oral oral JJ cord-010092-uftc8inx 12821 7 anticoagulants anticoagulant NNS cord-010092-uftc8inx 12821 8 ( ( -LRB- cord-010092-uftc8inx 12821 9 dabigatran dabigatran NNP cord-010092-uftc8inx 12821 10 , , , cord-010092-uftc8inx 12821 11 rivaroxaban rivaroxaban NNP cord-010092-uftc8inx 12821 12 , , , cord-010092-uftc8inx 12821 13 apixaban apixaban NNP cord-010092-uftc8inx 12821 14 ) ) -RRB- cord-010092-uftc8inx 12821 15 , , , cord-010092-uftc8inx 12821 16 vitamin vitamin NN cord-010092-uftc8inx 12821 17 K K NNP cord-010092-uftc8inx 12821 18 antagonists antagonist NNS cord-010092-uftc8inx 12821 19 ( ( -LRB- cord-010092-uftc8inx 12821 20 VKA VKA NNP cord-010092-uftc8inx 12821 21 ) ) -RRB- cord-010092-uftc8inx 12821 22 , , , cord-010092-uftc8inx 12821 23 such such JJ cord-010092-uftc8inx 12821 24 as as IN cord-010092-uftc8inx 12821 25 warfarin warfarin NN cord-010092-uftc8inx 12821 26 and and CC cord-010092-uftc8inx 12821 27 acenocoumarol acenocoumarol NNP cord-010092-uftc8inx 12821 28 are be VBP cord-010092-uftc8inx 12821 29 still still RB cord-010092-uftc8inx 12821 30 the the DT cord-010092-uftc8inx 12821 31 most most RBS cord-010092-uftc8inx 12821 32 widely widely RB cord-010092-uftc8inx 12821 33 used use VBN cord-010092-uftc8inx 12821 34 oral oral JJ cord-010092-uftc8inx 12821 35 anticoagulants anticoagulant NNS cord-010092-uftc8inx 12821 36 for for IN cord-010092-uftc8inx 12821 37 the the DT cord-010092-uftc8inx 12821 38 treatment treatment NN cord-010092-uftc8inx 12821 39 of of IN cord-010092-uftc8inx 12821 40 non non JJ cord-010092-uftc8inx 12821 41 - - JJ cord-010092-uftc8inx 12821 42 valvular valvular JJ cord-010092-uftc8inx 12821 43 atrial atrial JJ cord-010092-uftc8inx 12821 44 fibrillation fibrillation NN cord-010092-uftc8inx 12821 45 ( ( -LRB- cord-010092-uftc8inx 12821 46 NVAF NVAF NNP cord-010092-uftc8inx 12821 47 ) ) -RRB- cord-010092-uftc8inx 12821 48 . . . cord-010092-uftc8inx 12822 1 The the DT cord-010092-uftc8inx 12822 2 use use NN cord-010092-uftc8inx 12822 3 of of IN cord-010092-uftc8inx 12822 4 VKA VKA NNP cord-010092-uftc8inx 12822 5 must must MD cord-010092-uftc8inx 12822 6 be be VB cord-010092-uftc8inx 12822 7 regularly regularly RB cord-010092-uftc8inx 12822 8 and and CC cord-010092-uftc8inx 12822 9 often often RB cord-010092-uftc8inx 12822 10 laboratory laboratory NN cord-010092-uftc8inx 12822 11 controlled control VBN cord-010092-uftc8inx 12822 12 in in IN cord-010092-uftc8inx 12822 13 order order NN cord-010092-uftc8inx 12822 14 to to TO cord-010092-uftc8inx 12822 15 ensure ensure VB cord-010092-uftc8inx 12822 16 the the DT cord-010092-uftc8inx 12822 17 adequacy adequacy NN cord-010092-uftc8inx 12822 18 of of IN cord-010092-uftc8inx 12822 19 therapy therapy NN cord-010092-uftc8inx 12822 20 and and CC cord-010092-uftc8inx 12822 21 to to TO cord-010092-uftc8inx 12822 22 avoid avoid VB cord-010092-uftc8inx 12822 23 subdosing subdose VBG cord-010092-uftc8inx 12822 24 or or CC cord-010092-uftc8inx 12822 25 drug drug NN cord-010092-uftc8inx 12822 26 overdose overdose NN cord-010092-uftc8inx 12822 27 . . . cord-010092-uftc8inx 12823 1 The the DT cord-010092-uftc8inx 12823 2 most most RBS cord-010092-uftc8inx 12823 3 commonly commonly RB cord-010092-uftc8inx 12823 4 used use VBN cord-010092-uftc8inx 12823 5 test test NN cord-010092-uftc8inx 12823 6 for for IN cord-010092-uftc8inx 12823 7 the the DT cord-010092-uftc8inx 12823 8 control control NN cord-010092-uftc8inx 12823 9 of of IN cord-010092-uftc8inx 12823 10 oral oral JJ cord-010092-uftc8inx 12823 11 anticoagulant anticoagulant NN cord-010092-uftc8inx 12823 12 therapy therapy NN cord-010092-uftc8inx 12823 13 is be VBZ cord-010092-uftc8inx 12823 14 the the DT cord-010092-uftc8inx 12823 15 prothrombin prothrombin JJ cord-010092-uftc8inx 12823 16 time time NN cord-010092-uftc8inx 12823 17 ( ( -LRB- cord-010092-uftc8inx 12823 18 PT PT NNP cord-010092-uftc8inx 12823 19 ) ) -RRB- cord-010092-uftc8inx 12823 20 , , , cord-010092-uftc8inx 12823 21 expressed express VBN cord-010092-uftc8inx 12823 22 in in IN cord-010092-uftc8inx 12823 23 INR INR NNP cord-010092-uftc8inx 12823 24 system system NN cord-010092-uftc8inx 12823 25 , , , cord-010092-uftc8inx 12823 26 which which WDT cord-010092-uftc8inx 12823 27 provides provide VBZ cord-010092-uftc8inx 12823 28 an an DT cord-010092-uftc8inx 12823 29 internationally internationally RB cord-010092-uftc8inx 12823 30 standardized standardize VBN cord-010092-uftc8inx 12823 31 monitoring monitoring NN cord-010092-uftc8inx 12823 32 of of IN cord-010092-uftc8inx 12823 33 the the DT cord-010092-uftc8inx 12823 34 treatment treatment NN cord-010092-uftc8inx 12823 35 . . . cord-010092-uftc8inx 12824 1 Time time NN cord-010092-uftc8inx 12824 2 in in IN cord-010092-uftc8inx 12824 3 therapeutic therapeutic JJ cord-010092-uftc8inx 12824 4 range range NN cord-010092-uftc8inx 12825 1 ( ( -LRB- cord-010092-uftc8inx 12825 2 TTR TTR NNP cord-010092-uftc8inx 12825 3 ) ) -RRB- cord-010092-uftc8inx 12825 4 represents represent VBZ cord-010092-uftc8inx 12825 5 a a DT cord-010092-uftc8inx 12825 6 measure measure NN cord-010092-uftc8inx 12825 7 of of IN cord-010092-uftc8inx 12825 8 the the DT cord-010092-uftc8inx 12825 9 quality quality NN cord-010092-uftc8inx 12825 10 of of IN cord-010092-uftc8inx 12825 11 the the DT cord-010092-uftc8inx 12825 12 anticoagulant anticoagulant JJ cord-010092-uftc8inx 12825 13 effect effect NN cord-010092-uftc8inx 12825 14 of of IN cord-010092-uftc8inx 12825 15 VKA VKA NNP cord-010092-uftc8inx 12825 16 and and CC cord-010092-uftc8inx 12825 17 estimates estimate VBZ cord-010092-uftc8inx 12825 18 a a DT cord-010092-uftc8inx 12825 19 percentage percentage NN cord-010092-uftc8inx 12825 20 of of IN cord-010092-uftc8inx 12825 21 time time NN cord-010092-uftc8inx 12825 22 a a DT cord-010092-uftc8inx 12825 23 patient patient NN cord-010092-uftc8inx 12825 24 's 's POS cord-010092-uftc8inx 12825 25 INR INR NNP cord-010092-uftc8inx 12825 26 is be VBZ cord-010092-uftc8inx 12825 27 within within IN cord-010092-uftc8inx 12825 28 the the DT cord-010092-uftc8inx 12825 29 desired desire VBN cord-010092-uftc8inx 12825 30 therapeutic therapeutic JJ cord-010092-uftc8inx 12825 31 . . . cord-010092-uftc8inx 12826 1 Aims aim VBZ cord-010092-uftc8inx 12826 2 : : : cord-010092-uftc8inx 12827 1 The the DT cord-010092-uftc8inx 12827 2 aim aim NN cord-010092-uftc8inx 12827 3 of of IN cord-010092-uftc8inx 12827 4 this this DT cord-010092-uftc8inx 12827 5 study study NN cord-010092-uftc8inx 12827 6 was be VBD cord-010092-uftc8inx 12827 7 to to TO cord-010092-uftc8inx 12827 8 evaluate evaluate VB cord-010092-uftc8inx 12827 9 of of IN cord-010092-uftc8inx 12827 10 the the DT cord-010092-uftc8inx 12827 11 effectiveness effectiveness NN cord-010092-uftc8inx 12827 12 of of IN cord-010092-uftc8inx 12827 13 VKA VKA NNP cord-010092-uftc8inx 12827 14 therapy therapy NN cord-010092-uftc8inx 12827 15 in in IN cord-010092-uftc8inx 12827 16 patients patient NNS cord-010092-uftc8inx 12827 17 with with IN cord-010092-uftc8inx 12827 18 NVAF NVAF NNP cord-010092-uftc8inx 12827 19 and and CC cord-010092-uftc8inx 12827 20 to to TO cord-010092-uftc8inx 12827 21 identify identify VB cord-010092-uftc8inx 12827 22 factors factor NNS cord-010092-uftc8inx 12827 23 affecting affect VBG cord-010092-uftc8inx 12827 24 the the DT cord-010092-uftc8inx 12827 25 anticoagulation anticoagulation NN cord-010092-uftc8inx 12827 26 efficacy efficacy NN cord-010092-uftc8inx 12827 27 . . . cord-010092-uftc8inx 12828 1 Methods method NNS cord-010092-uftc8inx 12828 2 : : : cord-010092-uftc8inx 12828 3 A a DT cord-010092-uftc8inx 12828 4 retrospective retrospective JJ cord-010092-uftc8inx 12828 5 study study NN cord-010092-uftc8inx 12828 6 was be VBD cord-010092-uftc8inx 12828 7 conducted conduct VBN cord-010092-uftc8inx 12828 8 on on IN cord-010092-uftc8inx 12828 9 a a DT cord-010092-uftc8inx 12828 10 population population NN cord-010092-uftc8inx 12828 11 of of IN cord-010092-uftc8inx 12828 12 725 725 CD cord-010092-uftc8inx 12828 13 outpatients outpatient NNS cord-010092-uftc8inx 12828 14 with with IN cord-010092-uftc8inx 12828 15 NVAF NVAF NNP cord-010092-uftc8inx 12828 16 , , , cord-010092-uftc8inx 12828 17 treated treat VBN cord-010092-uftc8inx 12828 18 with with IN cord-010092-uftc8inx 12828 19 VKA VKA NNP cord-010092-uftc8inx 12828 20 and and CC cord-010092-uftc8inx 12828 21 followed follow VBD cord-010092-uftc8inx 12828 22 in in IN cord-010092-uftc8inx 12828 23 Blood Blood NNP cord-010092-uftc8inx 12828 24 Transfusion Transfusion NNP cord-010092-uftc8inx 12828 25 Institute Institute NNP cord-010092-uftc8inx 12828 26 of of IN cord-010092-uftc8inx 12828 27 Ni Ni NNP cord-010092-uftc8inx 12828 28 s s NNP cord-010092-uftc8inx 12828 29 from from IN cord-010092-uftc8inx 12828 30 January January NNP cord-010092-uftc8inx 12828 31 to to IN cord-010092-uftc8inx 12828 32 December December NNP cord-010092-uftc8inx 12828 33 2017 2017 CD cord-010092-uftc8inx 12828 34 . . . cord-010092-uftc8inx 12829 1 Laboratory laboratory NN cord-010092-uftc8inx 12829 2 control control NN cord-010092-uftc8inx 12829 3 of of IN cord-010092-uftc8inx 12829 4 INR INR NNP cord-010092-uftc8inx 12829 5 was be VBD cord-010092-uftc8inx 12829 6 done do VBN cord-010092-uftc8inx 12829 7 from from IN cord-010092-uftc8inx 12829 8 capillary capillary JJ cord-010092-uftc8inx 12829 9 blood blood NN cord-010092-uftc8inx 12829 10 of of IN cord-010092-uftc8inx 12829 11 patients patient NNS cord-010092-uftc8inx 12829 12 on on IN cord-010092-uftc8inx 12829 13 Thrombotrack Thrombotrack NNP cord-010092-uftc8inx 12829 14 Solo Solo NNP cord-010092-uftc8inx 12829 15 ( ( -LRB- cord-010092-uftc8inx 12829 16 Axis Axis NNP cord-010092-uftc8inx 12829 17 Shield Shield NNP cord-010092-uftc8inx 12829 18 , , , cord-010092-uftc8inx 12829 19 Norway Norway NNP cord-010092-uftc8inx 12829 20 ) ) -RRB- cord-010092-uftc8inx 12829 21 and and CC cord-010092-uftc8inx 12829 22 Thrombostat Thrombostat NNP cord-010092-uftc8inx 12829 23 ( ( -LRB- cord-010092-uftc8inx 12829 24 Behnk Behnk NNP cord-010092-uftc8inx 12829 25 Elektronik Elektronik NNP cord-010092-uftc8inx 12829 26 , , , cord-010092-uftc8inx 12829 27 Germany Germany NNP cord-010092-uftc8inx 12829 28 ) ) -RRB- cord-010092-uftc8inx 12829 29 . . . cord-010092-uftc8inx 12830 1 Targeted target VBN cord-010092-uftc8inx 12830 2 15 15 CD cord-010092-uftc8inx 12830 3 AE AE NNP cord-010092-uftc8inx 12830 4 17.52 17.52 CD cord-010092-uftc8inx 12830 5 % % NN cord-010092-uftc8inx 12830 6 , , , cord-010092-uftc8inx 12830 7 but but CC cord-010092-uftc8inx 12830 8 49.72 49.72 CD cord-010092-uftc8inx 12830 9 % % NN cord-010092-uftc8inx 12830 10 of of IN cord-010092-uftc8inx 12830 11 patients patient NNS cord-010092-uftc8inx 12830 12 had have VBD cord-010092-uftc8inx 12830 13 a a DT cord-010092-uftc8inx 12830 14 TTR TTR NNP cord-010092-uftc8inx 12830 15 less less JJR cord-010092-uftc8inx 12830 16 than than IN cord-010092-uftc8inx 12830 17 60 60 CD cord-010092-uftc8inx 12830 18 % % NN cord-010092-uftc8inx 12830 19 . . . cord-010092-uftc8inx 12831 1 Patients patient NNS cord-010092-uftc8inx 12831 2 were be VBD cord-010092-uftc8inx 12831 3 at at IN cord-010092-uftc8inx 12831 4 high high JJ cord-010092-uftc8inx 12831 5 risk risk NN cord-010092-uftc8inx 12831 6 of of IN cord-010092-uftc8inx 12831 7 thrombosis thrombosis NN cord-010092-uftc8inx 12831 8 in in IN cord-010092-uftc8inx 12831 9 6.15 6.15 CD cord-010092-uftc8inx 12831 10 % % NN cord-010092-uftc8inx 12831 11 of of IN cord-010092-uftc8inx 12831 12 time time NN cord-010092-uftc8inx 12831 13 ( ( -LRB- cord-010092-uftc8inx 12831 14 INR INR NNP cord-010092-uftc8inx 12831 15 < < XX cord-010092-uftc8inx 12831 16 1.5 1.5 CD cord-010092-uftc8inx 12831 17 ) ) -RRB- cord-010092-uftc8inx 12831 18 and and CC cord-010092-uftc8inx 12831 19 high high JJ cord-010092-uftc8inx 12831 20 risk risk NN cord-010092-uftc8inx 12831 21 of of IN cord-010092-uftc8inx 12831 22 bleeding bleed VBG cord-010092-uftc8inx 12831 23 in in IN cord-010092-uftc8inx 12831 24 2.2 2.2 CD cord-010092-uftc8inx 12831 25 % % NN cord-010092-uftc8inx 12831 26 of of IN cord-010092-uftc8inx 12831 27 time time NN cord-010092-uftc8inx 12831 28 ( ( -LRB- cord-010092-uftc8inx 12831 29 INR INR NNP cord-010092-uftc8inx 12831 30 > > XX cord-010092-uftc8inx 12831 31 4.5 4.5 CD cord-010092-uftc8inx 12831 32 ) ) -RRB- cord-010092-uftc8inx 12831 33 . . . cord-010092-uftc8inx 12832 1 The the DT cord-010092-uftc8inx 12832 2 most most RBS cord-010092-uftc8inx 12832 3 significant significant JJ cord-010092-uftc8inx 12832 4 independent independent JJ cord-010092-uftc8inx 12832 5 factors factor NNS cord-010092-uftc8inx 12832 6 affecting affect VBG cord-010092-uftc8inx 12832 7 the the DT cord-010092-uftc8inx 12832 8 quality quality NN cord-010092-uftc8inx 12832 9 of of IN cord-010092-uftc8inx 12832 10 VKA VKA NNP cord-010092-uftc8inx 12832 11 therapy therapy NN cord-010092-uftc8inx 12832 12 are be VBP cord-010092-uftc8inx 12832 13 gender gender NN cord-010092-uftc8inx 12832 14 , , , cord-010092-uftc8inx 12832 15 arterial arterial JJ cord-010092-uftc8inx 12832 16 hypertension hypertension NN cord-010092-uftc8inx 12832 17 , , , cord-010092-uftc8inx 12832 18 diabetes diabete VBZ cord-010092-uftc8inx 12832 19 mellitus mellitus NN cord-010092-uftc8inx 12832 20 and and CC cord-010092-uftc8inx 12832 21 the the DT cord-010092-uftc8inx 12832 22 use use NN cord-010092-uftc8inx 12832 23 of of IN cord-010092-uftc8inx 12832 24 amiodarone amiodarone NN cord-010092-uftc8inx 12832 25 and and CC cord-010092-uftc8inx 12832 26 antiplatelet antiplatelet JJ cord-010092-uftc8inx 12832 27 drugs drug NNS cord-010092-uftc8inx 12832 28 ( ( -LRB- cord-010092-uftc8inx 12832 29 aspirin aspirin NN cord-010092-uftc8inx 12832 30 , , , cord-010092-uftc8inx 12832 31 clopidogrel clopidogrel NNP cord-010092-uftc8inx 12832 32 ) ) -RRB- cord-010092-uftc8inx 12832 33 . . . cord-010092-uftc8inx 12833 1 Summary Summary NNP cord-010092-uftc8inx 12833 2 / / SYM cord-010092-uftc8inx 12833 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 12833 4 : : : cord-010092-uftc8inx 12834 1 The the DT cord-010092-uftc8inx 12834 2 TTR TTR NNP cord-010092-uftc8inx 12834 3 is be VBZ cord-010092-uftc8inx 12834 4 undoubtedly undoubtedly RB cord-010092-uftc8inx 12834 5 useful useful JJ cord-010092-uftc8inx 12834 6 indicator indicator NN cord-010092-uftc8inx 12834 7 of of IN cord-010092-uftc8inx 12834 8 the the DT cord-010092-uftc8inx 12834 9 effectiveness effectiveness NN cord-010092-uftc8inx 12834 10 of of IN cord-010092-uftc8inx 12834 11 VKA VKA NNP cord-010092-uftc8inx 12834 12 treatment treatment NN cord-010092-uftc8inx 12834 13 . . . cord-010092-uftc8inx 12835 1 The the DT cord-010092-uftc8inx 12835 2 most most RBS cord-010092-uftc8inx 12835 3 important important JJ cord-010092-uftc8inx 12835 4 predictors predictor NNS cord-010092-uftc8inx 12835 5 of of IN cord-010092-uftc8inx 12835 6 poorer poor JJR cord-010092-uftc8inx 12835 7 efficacy efficacy NN cord-010092-uftc8inx 12835 8 of of IN cord-010092-uftc8inx 12835 9 VKA VKA NNP cord-010092-uftc8inx 12835 10 therapy therapy NN cord-010092-uftc8inx 12835 11 are be VBP cord-010092-uftc8inx 12835 12 arterial arterial JJ cord-010092-uftc8inx 12835 13 hypertension hypertension NN cord-010092-uftc8inx 12835 14 , , , cord-010092-uftc8inx 12835 15 diabetes diabetes NN cord-010092-uftc8inx 12835 16 mellitus mellitus NN cord-010092-uftc8inx 12835 17 , , , cord-010092-uftc8inx 12835 18 patients patient NNS cord-010092-uftc8inx 12835 19 ' ' POS cord-010092-uftc8inx 12835 20 gender gender NN cord-010092-uftc8inx 12835 21 and and CC cord-010092-uftc8inx 12835 22 the the DT cord-010092-uftc8inx 12835 23 use use NN cord-010092-uftc8inx 12835 24 of of IN cord-010092-uftc8inx 12835 25 amiodarone amiodarone NN cord-010092-uftc8inx 12835 26 and and CC cord-010092-uftc8inx 12835 27 antiplatelet antiplatelet NN cord-010092-uftc8inx 12835 28 ( ( -LRB- cord-010092-uftc8inx 12835 29 aspirin aspirin NN cord-010092-uftc8inx 12835 30 , , , cord-010092-uftc8inx 12835 31 clopidogrel clopidogrel NN cord-010092-uftc8inx 12835 32 ) ) -RRB- cord-010092-uftc8inx 12835 33 drugs drug NNS cord-010092-uftc8inx 12835 34 . . . cord-010092-uftc8inx 12836 1 To to TO cord-010092-uftc8inx 12836 2 improve improve VB cord-010092-uftc8inx 12836 3 the the DT cord-010092-uftc8inx 12836 4 quality quality NN cord-010092-uftc8inx 12836 5 of of IN cord-010092-uftc8inx 12836 6 VKA VKA NNP cord-010092-uftc8inx 12836 7 therapy therapy NN cord-010092-uftc8inx 12836 8 , , , cord-010092-uftc8inx 12836 9 education education NN cord-010092-uftc8inx 12836 10 of of IN cord-010092-uftc8inx 12836 11 patient patient NN cord-010092-uftc8inx 12836 12 and and CC cord-010092-uftc8inx 12836 13 better well JJR cord-010092-uftc8inx 12836 14 collaboration collaboration NN cord-010092-uftc8inx 12836 15 with with IN cord-010092-uftc8inx 12836 16 them -PRON- PRP cord-010092-uftc8inx 12836 17 , , , cord-010092-uftc8inx 12836 18 as as RB cord-010092-uftc8inx 12836 19 well well RB cord-010092-uftc8inx 12836 20 as as IN cord-010092-uftc8inx 12836 21 a a DT cord-010092-uftc8inx 12836 22 successful successful JJ cord-010092-uftc8inx 12836 23 teamwork teamwork NN cord-010092-uftc8inx 12836 24 with with IN cord-010092-uftc8inx 12836 25 clinicians clinician NNS cord-010092-uftc8inx 12836 26 are be VBP cord-010092-uftc8inx 12836 27 also also RB cord-010092-uftc8inx 12836 28 imperative imperative JJ cord-010092-uftc8inx 12836 29 . . . cord-010092-uftc8inx 12837 1 Background background NN cord-010092-uftc8inx 12837 2 : : : cord-010092-uftc8inx 12838 1 An an DT cord-010092-uftc8inx 12838 2 estimated estimate VBN cord-010092-uftc8inx 12838 3 1.9 1.9 CD cord-010092-uftc8inx 12838 4 million million CD cord-010092-uftc8inx 12838 5 deaths death NNS cord-010092-uftc8inx 12838 6 per per IN cord-010092-uftc8inx 12838 7 year year NN cord-010092-uftc8inx 12838 8 result result NN cord-010092-uftc8inx 12838 9 from from IN cord-010092-uftc8inx 12838 10 haemorrhagic haemorrhagic JJ cord-010092-uftc8inx 12838 11 blood blood NN cord-010092-uftc8inx 12838 12 loss loss NN cord-010092-uftc8inx 12838 13 . . . cord-010092-uftc8inx 12839 1 At at IN cord-010092-uftc8inx 12839 2 a a DT cord-010092-uftc8inx 12839 3 cellular cellular JJ cord-010092-uftc8inx 12839 4 level level NN cord-010092-uftc8inx 12839 5 , , , cord-010092-uftc8inx 12839 6 haemorrhagic haemorrhagic JJ cord-010092-uftc8inx 12839 7 shock shock NN cord-010092-uftc8inx 12839 8 develops develop VBZ cord-010092-uftc8inx 12839 9 when when WRB cord-010092-uftc8inx 12839 10 oxygen oxygen NN cord-010092-uftc8inx 12839 11 delivery delivery NN cord-010092-uftc8inx 12839 12 is be VBZ cord-010092-uftc8inx 12839 13 insufficient insufficient JJ cord-010092-uftc8inx 12839 14 to to TO cord-010092-uftc8inx 12839 15 meet meet VB cord-010092-uftc8inx 12839 16 oxygen oxygen NN cord-010092-uftc8inx 12839 17 requirements requirement NNS cord-010092-uftc8inx 12839 18 to to TO cord-010092-uftc8inx 12839 19 maintain maintain VB cord-010092-uftc8inx 12839 20 aerobic aerobic JJ cord-010092-uftc8inx 12839 21 metabolism metabolism NN cord-010092-uftc8inx 12839 22 . . . cord-010092-uftc8inx 12840 1 Successful successful JJ cord-010092-uftc8inx 12840 2 resuscitation resuscitation NN cord-010092-uftc8inx 12840 3 prevents prevent VBZ cord-010092-uftc8inx 12840 4 further further RB cord-010092-uftc8inx 12840 5 oxygen oxygen NN cord-010092-uftc8inx 12840 6 debt debt NN cord-010092-uftc8inx 12840 7 and and CC cord-010092-uftc8inx 12840 8 repays repay VBZ cord-010092-uftc8inx 12840 9 the the DT cord-010092-uftc8inx 12840 10 prior prior JJ cord-010092-uftc8inx 12840 11 oxygen oxygen NN cord-010092-uftc8inx 12840 12 debt debt NN cord-010092-uftc8inx 12840 13 . . . cord-010092-uftc8inx 12841 1 This this DT cord-010092-uftc8inx 12841 2 includes include VBZ cord-010092-uftc8inx 12841 3 the the DT cord-010092-uftc8inx 12841 4 administration administration NN cord-010092-uftc8inx 12841 5 of of IN cord-010092-uftc8inx 12841 6 fluids fluid NNS cord-010092-uftc8inx 12841 7 and and CC cord-010092-uftc8inx 12841 8 blood blood NN cord-010092-uftc8inx 12841 9 components component NNS cord-010092-uftc8inx 12841 10 ( ( -LRB- cord-010092-uftc8inx 12841 11 e.g. e.g. IN cord-010092-uftc8inx 12841 12 plasma plasma NN cord-010092-uftc8inx 12841 13 , , , cord-010092-uftc8inx 12841 14 red red JJ cord-010092-uftc8inx 12841 15 cells cell NNS cord-010092-uftc8inx 12841 16 and and CC cord-010092-uftc8inx 12841 17 platelets platelet NNS cord-010092-uftc8inx 12841 18 ) ) -RRB- cord-010092-uftc8inx 12841 19 . . . cord-010092-uftc8inx 12842 1 Measurement measurement NN cord-010092-uftc8inx 12842 2 of of IN cord-010092-uftc8inx 12842 3 oxygen oxygen NN cord-010092-uftc8inx 12842 4 delivery delivery NN cord-010092-uftc8inx 12842 5 and and CC cord-010092-uftc8inx 12842 6 utilisation utilisation NN cord-010092-uftc8inx 12842 7 at at IN cord-010092-uftc8inx 12842 8 a a DT cord-010092-uftc8inx 12842 9 tissue tissue NN cord-010092-uftc8inx 12842 10 level level NN cord-010092-uftc8inx 12842 11 requires require VBZ cord-010092-uftc8inx 12842 12 invasive invasive JJ cord-010092-uftc8inx 12842 13 monitoring monitoring NN cord-010092-uftc8inx 12842 14 not not RB cord-010092-uftc8inx 12842 15 possible possible JJ cord-010092-uftc8inx 12842 16 clinically clinically RB cord-010092-uftc8inx 12842 17 , , , cord-010092-uftc8inx 12842 18 meaning mean VBG cord-010092-uftc8inx 12842 19 that that IN cord-010092-uftc8inx 12842 20 surrogate surrogate JJ cord-010092-uftc8inx 12842 21 markers marker NNS cord-010092-uftc8inx 12842 22 such such JJ cord-010092-uftc8inx 12842 23 as as IN cord-010092-uftc8inx 12842 24 lactate lactate NN cord-010092-uftc8inx 12842 25 and and CC cord-010092-uftc8inx 12842 26 venous venous JJ cord-010092-uftc8inx 12842 27 oxygen oxygen NN cord-010092-uftc8inx 12842 28 saturation saturation NN cord-010092-uftc8inx 12842 29 ( ( -LRB- cord-010092-uftc8inx 12842 30 SvO SvO NNP cord-010092-uftc8inx 12842 31 2 2 CD cord-010092-uftc8inx 12842 32 ) ) -RRB- cord-010092-uftc8inx 12842 33 are be VBP cord-010092-uftc8inx 12842 34 used use VBN cord-010092-uftc8inx 12842 35 instead instead RB cord-010092-uftc8inx 12842 36 . . . cord-010092-uftc8inx 12843 1 New new JJ cord-010092-uftc8inx 12843 2 technologies technology NNS cord-010092-uftc8inx 12843 3 such such JJ cord-010092-uftc8inx 12843 4 as as IN cord-010092-uftc8inx 12843 5 incident incident NN cord-010092-uftc8inx 12843 6 dark dark JJ cord-010092-uftc8inx 12843 7 field field NN cord-010092-uftc8inx 12843 8 imaging imaging NN cord-010092-uftc8inx 12843 9 and and CC cord-010092-uftc8inx 12843 10 near near RB cord-010092-uftc8inx 12843 11 - - HYPH cord-010092-uftc8inx 12843 12 infrared infrared JJ cord-010092-uftc8inx 12843 13 spectroscopy spectroscopy NN cord-010092-uftc8inx 12843 14 may may MD cord-010092-uftc8inx 12843 15 offer offer VB cord-010092-uftc8inx 12843 16 a a DT cord-010092-uftc8inx 12843 17 non non JJ cord-010092-uftc8inx 12843 18 - - JJ cord-010092-uftc8inx 12843 19 invasive invasive JJ cord-010092-uftc8inx 12843 20 alternative alternative NN cord-010092-uftc8inx 12843 21 ; ; : cord-010092-uftc8inx 12843 22 however however RB cord-010092-uftc8inx 12843 23 their -PRON- PRP$ cord-010092-uftc8inx 12843 24 utility utility NN cord-010092-uftc8inx 12843 25 in in IN cord-010092-uftc8inx 12843 26 haemorrhagic haemorrhagic JJ cord-010092-uftc8inx 12843 27 shock shock NN cord-010092-uftc8inx 12843 28 remains remain VBZ cord-010092-uftc8inx 12843 29 Background background NN cord-010092-uftc8inx 12843 30 : : : cord-010092-uftc8inx 12843 31 Transfusion transfusion NN cord-010092-uftc8inx 12843 32 - - HYPH cord-010092-uftc8inx 12843 33 induced induce VBN cord-010092-uftc8inx 12843 34 red red JJ cord-010092-uftc8inx 12843 35 cell cell NN cord-010092-uftc8inx 12843 36 alloimmunization alloimmunization NN cord-010092-uftc8inx 12843 37 is be VBZ cord-010092-uftc8inx 12843 38 still still RB cord-010092-uftc8inx 12843 39 a a DT cord-010092-uftc8inx 12843 40 major major JJ cord-010092-uftc8inx 12843 41 challenge challenge NN cord-010092-uftc8inx 12843 42 in in IN cord-010092-uftc8inx 12843 43 transfusion transfusion NN cord-010092-uftc8inx 12843 44 practice practice NN cord-010092-uftc8inx 12843 45 . . . cord-010092-uftc8inx 12844 1 Besides besides IN cord-010092-uftc8inx 12844 2 logistic logistic JJ cord-010092-uftc8inx 12844 3 problems problem NNS cord-010092-uftc8inx 12844 4 for for IN cord-010092-uftc8inx 12844 5 the the DT cord-010092-uftc8inx 12844 6 transfusion transfusion NN cord-010092-uftc8inx 12844 7 laboratory laboratory NN cord-010092-uftc8inx 12844 8 , , , cord-010092-uftc8inx 12844 9 it -PRON- PRP cord-010092-uftc8inx 12844 10 may may MD cord-010092-uftc8inx 12844 11 compromise compromise VB cord-010092-uftc8inx 12844 12 available available JJ cord-010092-uftc8inx 12844 13 blood blood NN cord-010092-uftc8inx 12844 14 supply supply NN cord-010092-uftc8inx 12844 15 , , , cord-010092-uftc8inx 12844 16 and and CC cord-010092-uftc8inx 12844 17 when when WRB cord-010092-uftc8inx 12844 18 undetected undetected JJ cord-010092-uftc8inx 12844 19 and and CC cord-010092-uftc8inx 12844 20 unanticipated unanticipated JJ cord-010092-uftc8inx 12844 21 , , , cord-010092-uftc8inx 12844 22 it -PRON- PRP cord-010092-uftc8inx 12844 23 may may MD cord-010092-uftc8inx 12844 24 risk risk VB cord-010092-uftc8inx 12844 25 haemolytic haemolytic JJ cord-010092-uftc8inx 12844 26 transfusion transfusion NN cord-010092-uftc8inx 12844 27 reactions reaction NNS cord-010092-uftc8inx 12844 28 . . . cord-010092-uftc8inx 12845 1 Knowledge knowledge NN cord-010092-uftc8inx 12845 2 about about IN cord-010092-uftc8inx 12845 3 risk risk NN cord-010092-uftc8inx 12845 4 factors factor NNS cord-010092-uftc8inx 12845 5 can can MD cord-010092-uftc8inx 12845 6 help help VB cord-010092-uftc8inx 12845 7 to to TO cord-010092-uftc8inx 12845 8 optimize optimize VB cord-010092-uftc8inx 12845 9 preventive preventive JJ cord-010092-uftc8inx 12845 10 matching matching NN cord-010092-uftc8inx 12845 11 strategies strategy NNS cord-010092-uftc8inx 12845 12 . . . cord-010092-uftc8inx 12846 1 Severe severe JJ cord-010092-uftc8inx 12846 2 renal renal JJ cord-010092-uftc8inx 12846 3 failure failure NN cord-010092-uftc8inx 12846 4 and and CC cord-010092-uftc8inx 12846 5 subsequent subsequent JJ cord-010092-uftc8inx 12846 6 renal renal JJ cord-010092-uftc8inx 12846 7 replacement replacement NN cord-010092-uftc8inx 12846 8 therapy therapy NN cord-010092-uftc8inx 12846 9 influence influence VB cord-010092-uftc8inx 12846 10 the the DT cord-010092-uftc8inx 12846 11 immune immune JJ cord-010092-uftc8inx 12846 12 system system NN cord-010092-uftc8inx 12846 13 and and CC cord-010092-uftc8inx 12846 14 could could MD cord-010092-uftc8inx 12846 15 therefore therefore RB cord-010092-uftc8inx 12846 16 modulate modulate VB cord-010092-uftc8inx 12846 17 the the DT cord-010092-uftc8inx 12846 18 risk risk NN cord-010092-uftc8inx 12846 19 of of IN cord-010092-uftc8inx 12846 20 alloantibody alloantibody NN cord-010092-uftc8inx 12846 21 formation formation NN cord-010092-uftc8inx 12846 22 against against IN cord-010092-uftc8inx 12846 23 foreign foreign JJ cord-010092-uftc8inx 12846 24 red red JJ cord-010092-uftc8inx 12846 25 cell cell NN cord-010092-uftc8inx 12846 26 antigens antigen NNS cord-010092-uftc8inx 12846 27 subsequent subsequent JJ cord-010092-uftc8inx 12846 28 to to IN cord-010092-uftc8inx 12846 29 transfusion transfusion NN cord-010092-uftc8inx 12846 30 . . . cord-010092-uftc8inx 12847 1 Aims aim VBZ cord-010092-uftc8inx 12847 2 : : : cord-010092-uftc8inx 12848 1 This this DT cord-010092-uftc8inx 12848 2 study study NN cord-010092-uftc8inx 12848 3 aims aim VBZ cord-010092-uftc8inx 12848 4 to to TO cord-010092-uftc8inx 12848 5 quantify quantify VB cord-010092-uftc8inx 12848 6 the the DT cord-010092-uftc8inx 12848 7 association association NN cord-010092-uftc8inx 12848 8 between between IN cord-010092-uftc8inx 12848 9 renal renal JJ cord-010092-uftc8inx 12848 10 failure failure NN cord-010092-uftc8inx 12848 11 , , , cord-010092-uftc8inx 12848 12 according accord VBG cord-010092-uftc8inx 12848 13 to to IN cord-010092-uftc8inx 12848 14 its -PRON- PRP$ cord-010092-uftc8inx 12848 15 degree degree NN cord-010092-uftc8inx 12848 16 and and CC cord-010092-uftc8inx 12848 17 its -PRON- PRP$ cord-010092-uftc8inx 12848 18 treatment treatment NN cord-010092-uftc8inx 12848 19 with with IN cord-010092-uftc8inx 12848 20 renal renal JJ cord-010092-uftc8inx 12848 21 replacement replacement NN cord-010092-uftc8inx 12848 22 modalities modality NNS cord-010092-uftc8inx 12848 23 , , , cord-010092-uftc8inx 12848 24 and and CC cord-010092-uftc8inx 12848 25 transfusioninduced transfusioninduce VBD cord-010092-uftc8inx 12848 26 red red JJ cord-010092-uftc8inx 12848 27 cell cell NN cord-010092-uftc8inx 12848 28 alloantibody alloantibody NN cord-010092-uftc8inx 12848 29 formation formation NN cord-010092-uftc8inx 12848 30 . . . cord-010092-uftc8inx 12849 1 Methods method NNS cord-010092-uftc8inx 12849 2 : : : cord-010092-uftc8inx 12849 3 We -PRON- PRP cord-010092-uftc8inx 12849 4 performed perform VBD cord-010092-uftc8inx 12849 5 a a DT cord-010092-uftc8inx 12849 6 multicenter multicenter JJ cord-010092-uftc8inx 12849 7 case case NN cord-010092-uftc8inx 12849 8 - - HYPH cord-010092-uftc8inx 12849 9 control control NN cord-010092-uftc8inx 12849 10 study study NN cord-010092-uftc8inx 12849 11 within within IN cord-010092-uftc8inx 12849 12 a a DT cord-010092-uftc8inx 12849 13 source source NN cord-010092-uftc8inx 12849 14 population population NN cord-010092-uftc8inx 12849 15 of of IN cord-010092-uftc8inx 12849 16 patients patient NNS cord-010092-uftc8inx 12849 17 receiving receive VBG cord-010092-uftc8inx 12849 18 their -PRON- PRP$ cord-010092-uftc8inx 12849 19 first first JJ cord-010092-uftc8inx 12849 20 and and CC cord-010092-uftc8inx 12849 21 subsequent subsequent JJ cord-010092-uftc8inx 12849 22 red red JJ cord-010092-uftc8inx 12849 23 cell cell NN cord-010092-uftc8inx 12849 24 transfusion transfusion NN cord-010092-uftc8inx 12849 25 between between IN cord-010092-uftc8inx 12849 26 2005 2005 CD cord-010092-uftc8inx 12849 27 and and CC cord-010092-uftc8inx 12849 28 2015 2015 CD cord-010092-uftc8inx 12849 29 in in IN cord-010092-uftc8inx 12849 30 the the DT cord-010092-uftc8inx 12849 31 Netherlands Netherlands NNP cord-010092-uftc8inx 12850 1 ( ( -LRB- cord-010092-uftc8inx 12850 2 Risk Risk NNP cord-010092-uftc8inx 12850 3 Factors Factors NNP cord-010092-uftc8inx 12850 4 for for IN cord-010092-uftc8inx 12850 5 Alloimmunization Alloimmunization NNP cord-010092-uftc8inx 12850 6 after after IN cord-010092-uftc8inx 12850 7 red red JJ cord-010092-uftc8inx 12850 8 Cell Cell NNP cord-010092-uftc8inx 12850 9 Transfusion Transfusion NNP cord-010092-uftc8inx 12850 10 , , , cord-010092-uftc8inx 12850 11 R r NN cord-010092-uftc8inx 12850 12 - - HYPH cord-010092-uftc8inx 12850 13 FACT fact NN cord-010092-uftc8inx 12850 14 study study NN cord-010092-uftc8inx 12850 15 ) ) -RRB- cord-010092-uftc8inx 12850 16 . . . cord-010092-uftc8inx 12851 1 Using use VBG cord-010092-uftc8inx 12851 2 a a DT cord-010092-uftc8inx 12851 3 conditional conditional JJ cord-010092-uftc8inx 12851 4 multivariate multivariate JJ cord-010092-uftc8inx 12851 5 logistic logistic JJ cord-010092-uftc8inx 12851 6 regression regression NN cord-010092-uftc8inx 12851 7 , , , cord-010092-uftc8inx 12851 8 we -PRON- PRP cord-010092-uftc8inx 12851 9 compared compare VBD cord-010092-uftc8inx 12851 10 first first JJ cord-010092-uftc8inx 12851 11 - - HYPH cord-010092-uftc8inx 12851 12 time time NN cord-010092-uftc8inx 12851 13 transfusion transfusion NN cord-010092-uftc8inx 12851 14 - - HYPH cord-010092-uftc8inx 12851 15 induced induce VBN cord-010092-uftc8inx 12851 16 red red JJ cord-010092-uftc8inx 12851 17 cell cell NN cord-010092-uftc8inx 12851 18 alloantibody alloantibody NN cord-010092-uftc8inx 12851 19 formers former NNS cord-010092-uftc8inx 12851 20 ( ( -LRB- cord-010092-uftc8inx 12851 21 N n NN cord-010092-uftc8inx 12851 22 = = SYM cord-010092-uftc8inx 12851 23 505 505 CD cord-010092-uftc8inx 12851 24 ) ) -RRB- cord-010092-uftc8inx 12851 25 with with IN cord-010092-uftc8inx 12851 26 two two CD cord-010092-uftc8inx 12851 27 similarly similarly RB cord-010092-uftc8inx 12851 28 exposed expose VBN cord-010092-uftc8inx 12851 29 non non JJ cord-010092-uftc8inx 12851 30 - - JJ cord-010092-uftc8inx 12851 31 alloimmunized alloimmunized JJ cord-010092-uftc8inx 12851 32 control control NN cord-010092-uftc8inx 12851 33 recipients recipient NNS cord-010092-uftc8inx 12851 34 ( ( -LRB- cord-010092-uftc8inx 12851 35 N n NN cord-010092-uftc8inx 12851 36 = = SYM cord-010092-uftc8inx 12851 37 1010 1010 CD cord-010092-uftc8inx 12851 38 ) ) -RRB- cord-010092-uftc8inx 12851 39 during during IN cord-010092-uftc8inx 12851 40 a a DT cord-010092-uftc8inx 12851 41 five five CD cord-010092-uftc8inx 12851 42 - - HYPH cord-010092-uftc8inx 12851 43 week week NN cord-010092-uftc8inx 12851 44 alloimmunization alloimmunization NN cord-010092-uftc8inx 12851 45 risk risk NN cord-010092-uftc8inx 12851 46 period period NN cord-010092-uftc8inx 12851 47 . . . cord-010092-uftc8inx 12852 1 Degree degree NN cord-010092-uftc8inx 12852 2 of of IN cord-010092-uftc8inx 12852 3 renal renal JJ cord-010092-uftc8inx 12852 4 function function NN cord-010092-uftc8inx 12852 5 was be VBD cord-010092-uftc8inx 12852 6 categorized categorize VBN cord-010092-uftc8inx 12852 7 as as IN cord-010092-uftc8inx 12852 8 : : : cord-010092-uftc8inx 12852 9 ' ' '' cord-010092-uftc8inx 12852 10 no no DT cord-010092-uftc8inx 12852 11 renal renal JJ cord-010092-uftc8inx 12852 12 failure failure NN cord-010092-uftc8inx 12852 13 ' ' '' cord-010092-uftc8inx 12852 14 i.e. i.e. FW cord-010092-uftc8inx 12852 15 glomerular glomerular JJ cord-010092-uftc8inx 12852 16 filtration filtration NN cord-010092-uftc8inx 12852 17 rate rate NN cord-010092-uftc8inx 12852 18 ( ( -LRB- cord-010092-uftc8inx 12852 19 GFR GFR NNP cord-010092-uftc8inx 12852 20 ) ) -RRB- cord-010092-uftc8inx 12852 21 > > NFP cord-010092-uftc8inx 12852 22 30 30 CD cord-010092-uftc8inx 12852 23 ml ml NN cord-010092-uftc8inx 12852 24 / / SYM cord-010092-uftc8inx 12852 25 min/1.73 min/1.73 JJ cord-010092-uftc8inx 12852 26 m m CD cord-010092-uftc8inx 12852 27 2 2 CD cord-010092-uftc8inx 12852 28 , , , cord-010092-uftc8inx 12852 29 ' ' '' cord-010092-uftc8inx 12852 30 moderate moderate JJ cord-010092-uftc8inx 12852 31 renal renal JJ cord-010092-uftc8inx 12852 32 failure failure NN cord-010092-uftc8inx 12852 33 ' ' '' cord-010092-uftc8inx 12852 34 i.e. i.e. FW cord-010092-uftc8inx 12852 35 GFR GFR NNP cord-010092-uftc8inx 12852 36 ≥ ≥ NNP cord-010092-uftc8inx 12852 37 10 10 CD cord-010092-uftc8inx 12852 38 - - SYM cord-010092-uftc8inx 12852 39 30 30 CD cord-010092-uftc8inx 12852 40 ml ml NN cord-010092-uftc8inx 12852 41 / / SYM cord-010092-uftc8inx 12852 42 min/1.73 min/1.73 JJ cord-010092-uftc8inx 12852 43 m m CD cord-010092-uftc8inx 12852 44 2 2 CD cord-010092-uftc8inx 12852 45 during during IN cord-010092-uftc8inx 12852 46 a a DT cord-010092-uftc8inx 12852 47 continuous continuous JJ cord-010092-uftc8inx 12852 48 period period NN cord-010092-uftc8inx 12852 49 of of IN cord-010092-uftc8inx 12852 50 minimally minimally RB cord-010092-uftc8inx 12852 51 seven seven CD cord-010092-uftc8inx 12852 52 days day NNS cord-010092-uftc8inx 12852 53 , , , cord-010092-uftc8inx 12852 54 ' ' '' cord-010092-uftc8inx 12852 55 severe severe JJ cord-010092-uftc8inx 12852 56 renal renal JJ cord-010092-uftc8inx 12852 57 failure failure NN cord-010092-uftc8inx 12852 58 ' ' '' cord-010092-uftc8inx 12852 59 i.e. i.e. FW cord-010092-uftc8inx 12852 60 GFR GFR NNP cord-010092-uftc8inx 12852 61 < < XX cord-010092-uftc8inx 12852 62 10 10 CD cord-010092-uftc8inx 12853 1 ml/ ml/ JJ cord-010092-uftc8inx 12854 1 min/1.73 min/1.73 JJ cord-010092-uftc8inx 12854 2 m m CD cord-010092-uftc8inx 12854 3 2 2 CD cord-010092-uftc8inx 12855 1 and/or and/or CC cord-010092-uftc8inx 12855 2 use use NN cord-010092-uftc8inx 12855 3 of of IN cord-010092-uftc8inx 12855 4 any any DT cord-010092-uftc8inx 12855 5 type type NN cord-010092-uftc8inx 12855 6 of of IN cord-010092-uftc8inx 12855 7 renal renal JJ cord-010092-uftc8inx 12855 8 replacement replacement NN cord-010092-uftc8inx 12855 9 therapy therapy NN cord-010092-uftc8inx 12855 10 during during IN cord-010092-uftc8inx 12855 11 at at RB cord-010092-uftc8inx 12855 12 least least RBS cord-010092-uftc8inx 12855 13 one one CD cord-010092-uftc8inx 12855 14 day day NN cord-010092-uftc8inx 12855 15 of of IN cord-010092-uftc8inx 12855 16 the the DT cord-010092-uftc8inx 12855 17 alloimmunization alloimmunization NN cord-010092-uftc8inx 12855 18 risk risk NN cord-010092-uftc8inx 12855 19 period period NN cord-010092-uftc8inx 12855 20 . . . cord-010092-uftc8inx 12856 1 Odds odd NNS cord-010092-uftc8inx 12856 2 ratios ratio NNS cord-010092-uftc8inx 12856 3 were be VBD cord-010092-uftc8inx 12856 4 interpreted interpret VBN cord-010092-uftc8inx 12856 5 and and CC cord-010092-uftc8inx 12856 6 presented present VBN cord-010092-uftc8inx 12856 7 as as IN cord-010092-uftc8inx 12856 8 relative relative JJ cord-010092-uftc8inx 12856 9 risks risk NNS cord-010092-uftc8inx 12856 10 ( ( -LRB- cord-010092-uftc8inx 12856 11 RR rr NN cord-010092-uftc8inx 12856 12 ) ) -RRB- cord-010092-uftc8inx 12856 13 . . . cord-010092-uftc8inx 12857 1 Adjusted adjust VBN cord-010092-uftc8inx 12857 2 RRs rr NNS cord-010092-uftc8inx 12857 3 were be VBD cord-010092-uftc8inx 12857 4 conditioned condition VBN cord-010092-uftc8inx 12857 5 on on IN cord-010092-uftc8inx 12857 6 the the DT cord-010092-uftc8inx 12857 7 matching matching NN cord-010092-uftc8inx 12857 8 variables variable NNS cord-010092-uftc8inx 12857 9 and and CC cord-010092-uftc8inx 12857 10 identified identify VBD cord-010092-uftc8inx 12857 11 confounders confounder NNS cord-010092-uftc8inx 12857 12 . . . cord-010092-uftc8inx 12858 1 Results result NNS cord-010092-uftc8inx 12858 2 : : : cord-010092-uftc8inx 12859 1 No no DT cord-010092-uftc8inx 12859 2 renal renal JJ cord-010092-uftc8inx 12859 3 failure failure NN cord-010092-uftc8inx 12859 4 was be VBD cord-010092-uftc8inx 12859 5 observed observe VBN cord-010092-uftc8inx 12859 6 among among IN cord-010092-uftc8inx 12859 7 441 441 CD cord-010092-uftc8inx 12859 8 ( ( -LRB- cord-010092-uftc8inx 12859 9 87.3 87.3 CD cord-010092-uftc8inx 12859 10 % % NN cord-010092-uftc8inx 12859 11 ) ) -RRB- cord-010092-uftc8inx 12859 12 cases case NNS cord-010092-uftc8inx 12859 13 versus versus IN cord-010092-uftc8inx 12859 14 838 838 CD cord-010092-uftc8inx 12859 15 ( ( -LRB- cord-010092-uftc8inx 12859 16 83.0 83.0 CD cord-010092-uftc8inx 12859 17 % % NN cord-010092-uftc8inx 12859 18 ) ) -RRB- cord-010092-uftc8inx 12859 19 controls control NNS cord-010092-uftc8inx 12859 20 ; ; : cord-010092-uftc8inx 12859 21 moderate moderate JJ cord-010092-uftc8inx 12859 22 renal renal JJ cord-010092-uftc8inx 12859 23 failure failure NN cord-010092-uftc8inx 12859 24 among among IN cord-010092-uftc8inx 12859 25 24 24 CD cord-010092-uftc8inx 12859 26 ( ( -LRB- cord-010092-uftc8inx 12859 27 4.8 4.8 CD cord-010092-uftc8inx 12859 28 % % NN cord-010092-uftc8inx 12859 29 ) ) -RRB- cord-010092-uftc8inx 12859 30 cases case NNS cord-010092-uftc8inx 12859 31 versus versus IN cord-010092-uftc8inx 12859 32 54 54 CD cord-010092-uftc8inx 12859 33 ( ( -LRB- cord-010092-uftc8inx 12859 34 5.3 5.3 CD cord-010092-uftc8inx 12859 35 % % NN cord-010092-uftc8inx 12859 36 ) ) -RRB- cord-010092-uftc8inx 12859 37 controls control NNS cord-010092-uftc8inx 12859 38 ; ; : cord-010092-uftc8inx 12859 39 and and CC cord-010092-uftc8inx 12859 40 severe severe JJ cord-010092-uftc8inx 12859 41 renal renal JJ cord-010092-uftc8inx 12859 42 failure failure NN cord-010092-uftc8inx 12859 43 among among IN cord-010092-uftc8inx 12859 44 40 40 CD cord-010092-uftc8inx 12859 45 ( ( -LRB- cord-010092-uftc8inx 12859 46 7.9 7.9 CD cord-010092-uftc8inx 12859 47 % % NN cord-010092-uftc8inx 12859 48 ) ) -RRB- cord-010092-uftc8inx 12859 49 cases case NNS cord-010092-uftc8inx 12859 50 versus versus IN cord-010092-uftc8inx 12859 51 108 108 CD cord-010092-uftc8inx 12859 52 ( ( -LRB- cord-010092-uftc8inx 12859 53 11.7 11.7 CD cord-010092-uftc8inx 12859 54 % % NN cord-010092-uftc8inx 12859 55 ) ) -RRB- cord-010092-uftc8inx 12859 56 controls control NNS cord-010092-uftc8inx 12859 57 . . . cord-010092-uftc8inx 12860 1 Among among IN cord-010092-uftc8inx 12860 2 the the DT cord-010092-uftc8inx 12860 3 latter latter JJ cord-010092-uftc8inx 12860 4 , , , cord-010092-uftc8inx 12860 5 30 30 CD cord-010092-uftc8inx 12860 6 cases case NNS cord-010092-uftc8inx 12860 7 and and CC cord-010092-uftc8inx 12860 8 97 97 CD cord-010092-uftc8inx 12860 9 controls control NNS cord-010092-uftc8inx 12860 10 underwent undergo VBD cord-010092-uftc8inx 12860 11 renal renal JJ cord-010092-uftc8inx 12860 12 replacement replacement NN cord-010092-uftc8inx 12860 13 therapy therapy NN cord-010092-uftc8inx 12860 14 . . . cord-010092-uftc8inx 12861 1 Moderate moderate JJ cord-010092-uftc8inx 12861 2 renal renal JJ cord-010092-uftc8inx 12861 3 failure failure NN cord-010092-uftc8inx 12861 4 and and CC cord-010092-uftc8inx 12861 5 severe severe JJ cord-010092-uftc8inx 12861 6 renal renal JJ cord-010092-uftc8inx 12861 7 failure failure NN cord-010092-uftc8inx 12861 8 without without IN cord-010092-uftc8inx 12861 9 renal renal JJ cord-010092-uftc8inx 12861 10 replacement replacement NN cord-010092-uftc8inx 12861 11 therapy therapy NN cord-010092-uftc8inx 12861 12 were be VBD cord-010092-uftc8inx 12861 13 not not RB cord-010092-uftc8inx 12861 14 significantly significantly RB cord-010092-uftc8inx 12861 15 associated associate VBN cord-010092-uftc8inx 12861 16 with with IN cord-010092-uftc8inx 12861 17 red red JJ cord-010092-uftc8inx 12861 18 cell cell NN cord-010092-uftc8inx 12861 19 alloimmunization alloimmunization NN cord-010092-uftc8inx 12861 20 ( ( -LRB- cord-010092-uftc8inx 12861 21 adjusted adjust VBN cord-010092-uftc8inx 12861 22 RR RR NNP cord-010092-uftc8inx 12861 23 0.82 0.82 CD cord-010092-uftc8inx 12861 24 , , , cord-010092-uftc8inx 12861 25 95 95 CD cord-010092-uftc8inx 12861 26 % % NN cord-010092-uftc8inx 12861 27 CI CI NNP cord-010092-uftc8inx 12861 28 0.67 0.67 CD cord-010092-uftc8inx 12861 29 - - SYM cord-010092-uftc8inx 12861 30 1.01 1.01 CD cord-010092-uftc8inx 12861 31 and and CC cord-010092-uftc8inx 12861 32 adjusted adjust VBN cord-010092-uftc8inx 12861 33 RR RR NNP cord-010092-uftc8inx 12861 34 0.81 0.81 CD cord-010092-uftc8inx 12861 35 , , , cord-010092-uftc8inx 12861 36 95 95 CD cord-010092-uftc8inx 12861 37 % % NN cord-010092-uftc8inx 12861 38 CI CI NNP cord-010092-uftc8inx 12861 39 0.58 0.58 CD cord-010092-uftc8inx 12861 40 - - SYM cord-010092-uftc8inx 12861 41 1.11 1.11 CD cord-010092-uftc8inx 12861 42 , , , cord-010092-uftc8inx 12861 43 respectively respectively RB cord-010092-uftc8inx 12861 44 ) ) -RRB- cord-010092-uftc8inx 12861 45 . . . cord-010092-uftc8inx 12862 1 However however RB cord-010092-uftc8inx 12862 2 , , , cord-010092-uftc8inx 12862 3 patients patient NNS cord-010092-uftc8inx 12862 4 undergoing undergo VBG cord-010092-uftc8inx 12862 5 renal renal JJ cord-010092-uftc8inx 12862 6 replacement replacement NN cord-010092-uftc8inx 12862 7 therapy therapy NN cord-010092-uftc8inx 12862 8 had have VBD cord-010092-uftc8inx 12862 9 a a DT cord-010092-uftc8inx 12862 10 two two CD cord-010092-uftc8inx 12862 11 - - HYPH cord-010092-uftc8inx 12862 12 fold fold VB cord-010092-uftc8inx 12862 13 lower low JJR cord-010092-uftc8inx 12862 14 alloimmunization alloimmunization NN cord-010092-uftc8inx 12862 15 risk risk NN cord-010092-uftc8inx 12862 16 ( ( -LRB- cord-010092-uftc8inx 12862 17 adjusted adjust VBN cord-010092-uftc8inx 12862 18 RR RR NNP cord-010092-uftc8inx 12862 19 0.48 0.48 CD cord-010092-uftc8inx 12862 20 , , , cord-010092-uftc8inx 12863 1 95 95 CD cord-010092-uftc8inx 12863 2 % % NN cord-010092-uftc8inx 12863 3 CI CI NNP cord-010092-uftc8inx 12863 4 0.39 0.39 CD cord-010092-uftc8inx 12863 5 - - HYPH cord-010092-uftc8inx 12863 6 0.59 0.59 CD cord-010092-uftc8inx 12863 7 ) ) -RRB- cord-010092-uftc8inx 12863 8 as as IN cord-010092-uftc8inx 12863 9 compared compare VBN cord-010092-uftc8inx 12863 10 to to IN cord-010092-uftc8inx 12863 11 transfusion transfusion NN cord-010092-uftc8inx 12863 12 recipients recipient NNS cord-010092-uftc8inx 12863 13 without without IN cord-010092-uftc8inx 12863 14 renal renal JJ cord-010092-uftc8inx 12863 15 failure failure NN cord-010092-uftc8inx 12863 16 , , , cord-010092-uftc8inx 12863 17 unrelated unrelated JJ cord-010092-uftc8inx 12863 18 to to TO cord-010092-uftc8inx 12863 19 type type NN cord-010092-uftc8inx 12863 20 and and CC cord-010092-uftc8inx 12863 21 duration duration NN cord-010092-uftc8inx 12863 22 of of IN cord-010092-uftc8inx 12863 23 renal renal JJ cord-010092-uftc8inx 12863 24 replacement replacement NN cord-010092-uftc8inx 12863 25 therapy therapy NN cord-010092-uftc8inx 12863 26 . . . cord-010092-uftc8inx 12864 1 Summary Summary NNP cord-010092-uftc8inx 12864 2 / / SYM cord-010092-uftc8inx 12864 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 12864 4 : : : cord-010092-uftc8inx 12865 1 These these DT cord-010092-uftc8inx 12865 2 findings finding NNS cord-010092-uftc8inx 12865 3 suggest suggest VBP cord-010092-uftc8inx 12865 4 that that IN cord-010092-uftc8inx 12865 5 patients patient NNS cord-010092-uftc8inx 12865 6 undergoing undergo VBG cord-010092-uftc8inx 12865 7 renal renal JJ cord-010092-uftc8inx 12865 8 replacement replacement NN cord-010092-uftc8inx 12865 9 therapy therapy NN cord-010092-uftc8inx 12865 10 have have VBP cord-010092-uftc8inx 12865 11 strongly strongly RB cord-010092-uftc8inx 12865 12 diminished diminish VBN cord-010092-uftc8inx 12865 13 red red JJ cord-010092-uftc8inx 12865 14 cell cell NN cord-010092-uftc8inx 12865 15 alloimmunization alloimmunization NN cord-010092-uftc8inx 12865 16 risks risk NNS cord-010092-uftc8inx 12865 17 . . . cord-010092-uftc8inx 12866 1 Further further JJ cord-010092-uftc8inx 12866 2 research research NN cord-010092-uftc8inx 12866 3 should should MD cord-010092-uftc8inx 12866 4 confirm confirm VB cord-010092-uftc8inx 12866 5 these these DT cord-010092-uftc8inx 12866 6 results result NNS cord-010092-uftc8inx 12866 7 and and CC cord-010092-uftc8inx 12866 8 elucidate elucidate VB cord-010092-uftc8inx 12866 9 the the DT cord-010092-uftc8inx 12866 10 underlying underlie VBG cord-010092-uftc8inx 12866 11 pathophysiological pathophysiological JJ cord-010092-uftc8inx 12866 12 protective protective JJ cord-010092-uftc8inx 12866 13 mechanism mechanism NN cord-010092-uftc8inx 12866 14 . . . cord-010092-uftc8inx 12867 1 Background background NN cord-010092-uftc8inx 12867 2 : : : cord-010092-uftc8inx 12868 1 The the DT cord-010092-uftc8inx 12868 2 ability ability NN cord-010092-uftc8inx 12868 3 of of IN cord-010092-uftc8inx 12868 4 allogeneic allogeneic NN cord-010092-uftc8inx 12868 5 hematopoietic hematopoietic JJ cord-010092-uftc8inx 12868 6 stem stem NN cord-010092-uftc8inx 12868 7 cell cell NN cord-010092-uftc8inx 12868 8 transplantation(allo transplantation(allo NN cord-010092-uftc8inx 12868 9 - - HYPH cord-010092-uftc8inx 12868 10 HSCT HSCT NNP cord-010092-uftc8inx 12868 11 ) ) -RRB- cord-010092-uftc8inx 12868 12 to to TO cord-010092-uftc8inx 12868 13 prevent prevent VB cord-010092-uftc8inx 12868 14 relapse relapse NN cord-010092-uftc8inx 12868 15 depends depend VBZ cord-010092-uftc8inx 12868 16 partly partly RB cord-010092-uftc8inx 12868 17 on on IN cord-010092-uftc8inx 12868 18 donor donor NN cord-010092-uftc8inx 12868 19 natural natural JJ cord-010092-uftc8inx 12868 20 killer killer NN cord-010092-uftc8inx 12868 21 ( ( -LRB- cord-010092-uftc8inx 12868 22 NK NK NNP cord-010092-uftc8inx 12868 23 ) ) -RRB- cord-010092-uftc8inx 12868 24 cell cell NN cord-010092-uftc8inx 12868 25 alloreactivity alloreactivity NN cord-010092-uftc8inx 12868 26 . . . cord-010092-uftc8inx 12869 1 NK NK NNP cord-010092-uftc8inx 12869 2 effector effector NN cord-010092-uftc8inx 12869 3 function function NN cord-010092-uftc8inx 12869 4 depends depend VBZ cord-010092-uftc8inx 12869 5 on on IN cord-010092-uftc8inx 12869 6 specific specific JJ cord-010092-uftc8inx 12869 7 killer killer NN cord-010092-uftc8inx 12869 8 - - HYPH cord-010092-uftc8inx 12869 9 cell cell NN cord-010092-uftc8inx 12869 10 immunoglobulin immunoglobulin NN cord-010092-uftc8inx 12869 11 - - HYPH cord-010092-uftc8inx 12869 12 like like JJ cord-010092-uftc8inx 12869 13 receptors receptor NNS cord-010092-uftc8inx 12869 14 ( ( -LRB- cord-010092-uftc8inx 12869 15 KIR KIR NNP cord-010092-uftc8inx 12869 16 ) ) -RRB- cord-010092-uftc8inx 12869 17 and and CC cord-010092-uftc8inx 12869 18 HLA HLA NNP cord-010092-uftc8inx 12869 19 interactions interaction NNS cord-010092-uftc8inx 12869 20 . . . cord-010092-uftc8inx 12870 1 Thus thus RB cord-010092-uftc8inx 12870 2 , , , cord-010092-uftc8inx 12870 3 it -PRON- PRP cord-010092-uftc8inx 12870 4 is be VBZ cord-010092-uftc8inx 12870 5 important important JJ cord-010092-uftc8inx 12870 6 to to TO cord-010092-uftc8inx 12870 7 identify identify VB cord-010092-uftc8inx 12870 8 optimal optimal JJ cord-010092-uftc8inx 12870 9 combinations combination NNS cord-010092-uftc8inx 12870 10 of of IN cord-010092-uftc8inx 12870 11 KIR KIR NNP cord-010092-uftc8inx 12870 12 - - HYPH cord-010092-uftc8inx 12870 13 HLA HLA NNP cord-010092-uftc8inx 12870 14 genotypes genotype NNS cord-010092-uftc8inx 12870 15 in in IN cord-010092-uftc8inx 12870 16 donors donor NNS cord-010092-uftc8inx 12870 17 and and CC cord-010092-uftc8inx 12870 18 recipients recipient NNS cord-010092-uftc8inx 12870 19 that that WDT cord-010092-uftc8inx 12870 20 could could MD cord-010092-uftc8inx 12870 21 improve improve VB cord-010092-uftc8inx 12870 22 hematopoietic hematopoietic JJ cord-010092-uftc8inx 12870 23 transplantation transplantation NN cord-010092-uftc8inx 12870 24 outcome outcome NN cord-010092-uftc8inx 12870 25 . . . cord-010092-uftc8inx 12871 1 Aims aim VBZ cord-010092-uftc8inx 12871 2 : : : cord-010092-uftc8inx 12872 1 To to TO cord-010092-uftc8inx 12872 2 obtain obtain VB cord-010092-uftc8inx 12872 3 the the DT cord-010092-uftc8inx 12872 4 optimal optimal JJ cord-010092-uftc8inx 12872 5 combinations combination NNS cord-010092-uftc8inx 12872 6 of of IN cord-010092-uftc8inx 12872 7 inhibitory inhibitory JJ cord-010092-uftc8inx 12872 8 KIR KIR NNP cord-010092-uftc8inx 12872 9 and and CC cord-010092-uftc8inx 12872 10 its -PRON- PRP$ cord-010092-uftc8inx 12872 11 ligand ligand NN cord-010092-uftc8inx 12872 12 between between IN cord-010092-uftc8inx 12872 13 donor donor NN cord-010092-uftc8inx 12872 14 and and CC cord-010092-uftc8inx 12872 15 recipient recipient NN cord-010092-uftc8inx 12872 16 which which WDT cord-010092-uftc8inx 12872 17 is be VBZ cord-010092-uftc8inx 12872 18 helpful helpful JJ cord-010092-uftc8inx 12872 19 for for IN cord-010092-uftc8inx 12872 20 the the DT cord-010092-uftc8inx 12872 21 guidance guidance NN cord-010092-uftc8inx 12872 22 of of IN cord-010092-uftc8inx 12872 23 selecting select VBG cord-010092-uftc8inx 12872 24 donors donor NNS cord-010092-uftc8inx 12872 25 and and CC cord-010092-uftc8inx 12872 26 recipients recipient NNS cord-010092-uftc8inx 12872 27 in in IN cord-010092-uftc8inx 12872 28 HSCT HSCT NNP cord-010092-uftc8inx 12872 29 . . . cord-010092-uftc8inx 12873 1 Methods method NNS cord-010092-uftc8inx 12873 2 : : : cord-010092-uftc8inx 12874 1 The the DT cord-010092-uftc8inx 12874 2 PCR PCR NNP cord-010092-uftc8inx 12874 3 - - HYPH cord-010092-uftc8inx 12874 4 SBT SBT NNP cord-010092-uftc8inx 12874 5 method method NN cord-010092-uftc8inx 12874 6 was be VBD cord-010092-uftc8inx 12874 7 used use VBN cord-010092-uftc8inx 12874 8 for for IN cord-010092-uftc8inx 12874 9 KIR2DL1 KIR2DL1 NNP cord-010092-uftc8inx 12874 10 , , , cord-010092-uftc8inx 12874 11 KIR2DL2 kir2dl2 FW cord-010092-uftc8inx 12874 12 / / SYM cord-010092-uftc8inx 12874 13 KIR2DL3 kir2dl3 NN cord-010092-uftc8inx 12874 14 , , , cord-010092-uftc8inx 12874 15 KIR3DL1 kir3dl1 CD cord-010092-uftc8inx 12874 16 , , , cord-010092-uftc8inx 12874 17 KIR3DL2 kir3dl2 CD cord-010092-uftc8inx 12874 18 and and CC cord-010092-uftc8inx 12874 19 HLA HLA NNP cord-010092-uftc8inx 12874 20 - - HYPH cord-010092-uftc8inx 12874 21 A A NNP cord-010092-uftc8inx 12874 22 , , , cord-010092-uftc8inx 12874 23 -B -b ADD cord-010092-uftc8inx 12874 24 , , , cord-010092-uftc8inx 12874 25 -C -C NNS cord-010092-uftc8inx 12874 26 , , , cord-010092-uftc8inx 12874 27 -DRB1 -DRB1 NNP cord-010092-uftc8inx 12874 28 , , , cord-010092-uftc8inx 12874 29 -DQB1 -dqb1 NN cord-010092-uftc8inx 12874 30 genotyping genotype VBG cord-010092-uftc8inx 12874 31 . . . cord-010092-uftc8inx 12875 1 58 58 CD cord-010092-uftc8inx 12875 2 pairs pair NNS cord-010092-uftc8inx 12875 3 of of IN cord-010092-uftc8inx 12875 4 HLA HLA NNP cord-010092-uftc8inx 12875 5 10/10 10/10 CD cord-010092-uftc8inx 12875 6 identical identical JJ cord-010092-uftc8inx 12875 7 donor donor NN cord-010092-uftc8inx 12875 8 / / SYM cord-010092-uftc8inx 12875 9 recipients recipient NNS cord-010092-uftc8inx 12875 10 matching match VBG cord-010092-uftc8inx 12875 11 samples sample NNS cord-010092-uftc8inx 12875 12 were be VBD cord-010092-uftc8inx 12875 13 retrospectively retrospectively RB cord-010092-uftc8inx 12875 14 analyzed analyze VBN cord-010092-uftc8inx 12875 15 . . . cord-010092-uftc8inx 12876 1 Three three CD cord-010092-uftc8inx 12876 2 different different JJ cord-010092-uftc8inx 12876 3 models model NNS cord-010092-uftc8inx 12876 4 of of IN cord-010092-uftc8inx 12876 5 KIR KIR NNP cord-010092-uftc8inx 12876 6 were be VBD cord-010092-uftc8inx 12876 7 established establish VBN cord-010092-uftc8inx 12876 8 . . . cord-010092-uftc8inx 12877 1 There there EX cord-010092-uftc8inx 12877 2 were be VBD cord-010092-uftc8inx 12877 3 KIR KIR NNP cord-010092-uftc8inx 12877 4 - - HYPH cord-010092-uftc8inx 12877 5 KIR KIR NNP cord-010092-uftc8inx 12877 6 gene gene NN cord-010092-uftc8inx 12877 7 model model NN cord-010092-uftc8inx 12877 8 , , , cord-010092-uftc8inx 12877 9 KIRligand kirligand NN cord-010092-uftc8inx 12877 10 model model NN cord-010092-uftc8inx 12877 11 and and CC cord-010092-uftc8inx 12877 12 haploid haploid JJ cord-010092-uftc8inx 12877 13 model model NN cord-010092-uftc8inx 12877 14 . . . cord-010092-uftc8inx 12878 1 In in IN cord-010092-uftc8inx 12878 2 KIR KIR NNP cord-010092-uftc8inx 12878 3 - - HYPH cord-010092-uftc8inx 12878 4 ligand ligand NN cord-010092-uftc8inx 12878 5 model model NN cord-010092-uftc8inx 12878 6 , , , cord-010092-uftc8inx 12878 7 patients patient NNS cord-010092-uftc8inx 12878 8 were be VBD cord-010092-uftc8inx 12878 9 divided divide VBN cord-010092-uftc8inx 12878 10 into into IN cord-010092-uftc8inx 12878 11 three three CD cord-010092-uftc8inx 12878 12 groups group NNS cord-010092-uftc8inx 12878 13 : : : cord-010092-uftc8inx 12878 14 C1 C1 NNP cord-010092-uftc8inx 12878 15 / / SYM cord-010092-uftc8inx 12878 16 C1 C1 NNP cord-010092-uftc8inx 12878 17 homozygote homozygote NNP cord-010092-uftc8inx 12878 18 group group NN cord-010092-uftc8inx 12878 19 ( ( -LRB- cord-010092-uftc8inx 12878 20 48 48 CD cord-010092-uftc8inx 12878 21 cases case NNS cord-010092-uftc8inx 12878 22 ) ) -RRB- cord-010092-uftc8inx 12878 23 , , , cord-010092-uftc8inx 12878 24 C1 C1 NNP cord-010092-uftc8inx 12878 25 / / SYM cord-010092-uftc8inx 12878 26 C2 C2 NNP cord-010092-uftc8inx 12878 27 heterozygote heterozygote NN cord-010092-uftc8inx 12878 28 group group NN cord-010092-uftc8inx 12878 29 ( ( -LRB- cord-010092-uftc8inx 12878 30 8 8 CD cord-010092-uftc8inx 12878 31 cases case NNS cord-010092-uftc8inx 12878 32 ) ) -RRB- cord-010092-uftc8inx 12878 33 and and CC cord-010092-uftc8inx 12878 34 C2 C2 NNP cord-010092-uftc8inx 12878 35 / / SYM cord-010092-uftc8inx 12878 36 C2 C2 NNP cord-010092-uftc8inx 12878 37 homozygote homozygote NNP cord-010092-uftc8inx 12878 38 group group NNP cord-010092-uftc8inx 12878 39 ( ( -LRB- cord-010092-uftc8inx 12878 40 2 2 CD cord-010092-uftc8inx 12878 41 cases case NNS cord-010092-uftc8inx 12878 42 ) ) -RRB- cord-010092-uftc8inx 12878 43 . . . cord-010092-uftc8inx 12879 1 According accord VBG cord-010092-uftc8inx 12879 2 to to IN cord-010092-uftc8inx 12879 3 the the DT cord-010092-uftc8inx 12879 4 expression expression NN cord-010092-uftc8inx 12879 5 of of IN cord-010092-uftc8inx 12879 6 3DL1 3dl1 CD cord-010092-uftc8inx 12879 7 , , , cord-010092-uftc8inx 12879 8 53 53 CD cord-010092-uftc8inx 12879 9 cases case NNS cord-010092-uftc8inx 12879 10 were be VBD cord-010092-uftc8inx 12879 11 3DL1 3dl1 CD cord-010092-uftc8inx 12879 12 positive positive JJ cord-010092-uftc8inx 12879 13 and and CC cord-010092-uftc8inx 12879 14 5 5 CD cord-010092-uftc8inx 12879 15 cases case NNS cord-010092-uftc8inx 12879 16 were be VBD cord-010092-uftc8inx 12879 17 3DL1 3dl1 CD cord-010092-uftc8inx 12879 18 negative negative JJ cord-010092-uftc8inx 12879 19 . . . cord-010092-uftc8inx 12880 1 There there EX cord-010092-uftc8inx 12880 2 were be VBD cord-010092-uftc8inx 12880 3 5 5 CD cord-010092-uftc8inx 12880 4 cases case NNS cord-010092-uftc8inx 12880 5 of of IN cord-010092-uftc8inx 12880 6 Bw4 bw4 NN cord-010092-uftc8inx 12880 7 / / SYM cord-010092-uftc8inx 12880 8 Bw4 bw4 NN cord-010092-uftc8inx 12880 9 , , , cord-010092-uftc8inx 12880 10 24 24 CD cord-010092-uftc8inx 12880 11 cases case NNS cord-010092-uftc8inx 12880 12 of of IN cord-010092-uftc8inx 12880 13 Bw4 bw4 NN cord-010092-uftc8inx 12880 14 / / SYM cord-010092-uftc8inx 12880 15 Bw6 bw6 CD cord-010092-uftc8inx 12880 16 and and CC cord-010092-uftc8inx 12880 17 24 24 CD cord-010092-uftc8inx 12880 18 cases case NNS cord-010092-uftc8inx 12880 19 of of IN cord-010092-uftc8inx 12880 20 Bw6 bw6 CD cord-010092-uftc8inx 12880 21 / / SYM cord-010092-uftc8inx 12880 22 Bw6 bw6 CD cord-010092-uftc8inx 12880 23 in in IN cord-010092-uftc8inx 12880 24 the the DT cord-010092-uftc8inx 12880 25 3DL1 3dl1 CD cord-010092-uftc8inx 12880 26 positive positive JJ cord-010092-uftc8inx 12880 27 samples sample NNS cord-010092-uftc8inx 12880 28 . . . cord-010092-uftc8inx 12881 1 According accord VBG cord-010092-uftc8inx 12881 2 to to IN cord-010092-uftc8inx 12881 3 the the DT cord-010092-uftc8inx 12881 4 expression expression NN cord-010092-uftc8inx 12881 5 of of IN cord-010092-uftc8inx 12881 6 A3 A3 NNP cord-010092-uftc8inx 12881 7 / / SYM cord-010092-uftc8inx 12881 8 A11 A11 NNP cord-010092-uftc8inx 12881 9 , , , cord-010092-uftc8inx 12881 10 they -PRON- PRP cord-010092-uftc8inx 12881 11 were be VBD cord-010092-uftc8inx 12881 12 divided divide VBN cord-010092-uftc8inx 12881 13 into into IN cord-010092-uftc8inx 12881 14 three three CD cord-010092-uftc8inx 12881 15 groups group NNS cord-010092-uftc8inx 12881 16 : : : cord-010092-uftc8inx 12882 1 A3 A3 NNP cord-010092-uftc8inx 12882 2 / / SYM cord-010092-uftc8inx 12882 3 A11 A11 NNP cord-010092-uftc8inx 12882 4 negative negative JJ cord-010092-uftc8inx 12882 5 group group NN cord-010092-uftc8inx 12882 6 ( ( -LRB- cord-010092-uftc8inx 12882 7 28 28 CD cord-010092-uftc8inx 12882 8 cases case NNS cord-010092-uftc8inx 12882 9 ) ) -RRB- cord-010092-uftc8inx 12882 10 , , . cord-010092-uftc8inx 12883 1 A3 A3 NNP cord-010092-uftc8inx 12883 2 / / SYM cord-010092-uftc8inx 12883 3 A11 A11 NNP cord-010092-uftc8inx 12883 4 heterozygous heterozygous JJ cord-010092-uftc8inx 12883 5 group group NN cord-010092-uftc8inx 12883 6 ( ( -LRB- cord-010092-uftc8inx 12883 7 28 28 CD cord-010092-uftc8inx 12883 8 cases case NNS cord-010092-uftc8inx 12883 9 ) ) -RRB- cord-010092-uftc8inx 12883 10 and and CC cord-010092-uftc8inx 12883 11 A11/ A11/ NNS cord-010092-uftc8inx 12883 12 A11 A11 NNP cord-010092-uftc8inx 12883 13 homozygote homozygote NN cord-010092-uftc8inx 12883 14 ( ( -LRB- cord-010092-uftc8inx 12883 15 2 2 CD cord-010092-uftc8inx 12883 16 cases case NNS cord-010092-uftc8inx 12883 17 ) ) -RRB- cord-010092-uftc8inx 12883 18 . . . cord-010092-uftc8inx 12884 1 According accord VBG cord-010092-uftc8inx 12884 2 to to IN cord-010092-uftc8inx 12884 3 KIR KIR NNP cord-010092-uftc8inx 12884 4 genotyping genotyping NN cord-010092-uftc8inx 12884 5 , , , cord-010092-uftc8inx 12884 6 KIR KIR NNP cord-010092-uftc8inx 12884 7 haploidentical haploidentical JJ cord-010092-uftc8inx 12884 8 group group NN cord-010092-uftc8inx 12884 9 ( ( -LRB- cord-010092-uftc8inx 12884 10 38 38 CD cord-010092-uftc8inx 12884 11 cases case NNS cord-010092-uftc8inx 12884 12 ) ) -RRB- cord-010092-uftc8inx 12884 13 and and CC cord-010092-uftc8inx 12884 14 KIR KIR NNP cord-010092-uftc8inx 12884 15 haploid haploid JJ cord-010092-uftc8inx 12884 16 mismatched mismatched JJ cord-010092-uftc8inx 12884 17 group group NN cord-010092-uftc8inx 12884 18 ( ( -LRB- cord-010092-uftc8inx 12884 19 20 20 CD cord-010092-uftc8inx 12884 20 cases case NNS cord-010092-uftc8inx 12884 21 ) ) -RRB- cord-010092-uftc8inx 12884 22 were be VBD cord-010092-uftc8inx 12884 23 divided divide VBN cord-010092-uftc8inx 12884 24 . . . cord-010092-uftc8inx 12885 1 The the DT cord-010092-uftc8inx 12885 2 clinical clinical JJ cord-010092-uftc8inx 12885 3 data datum NNS cord-010092-uftc8inx 12885 4 on on IN cord-010092-uftc8inx 12885 5 neutrophil neutrophil NN cord-010092-uftc8inx 12885 6 and and CC cord-010092-uftc8inx 12885 7 platelet platelet NN cord-010092-uftc8inx 12885 8 remodeling remodeling NN cord-010092-uftc8inx 12885 9 time time NN cord-010092-uftc8inx 12885 10 , , , cord-010092-uftc8inx 12885 11 GVHD GVHD NNP cord-010092-uftc8inx 12885 12 and and CC cord-010092-uftc8inx 12885 13 OS OS NNP cord-010092-uftc8inx 12885 14 of of IN cord-010092-uftc8inx 12885 15 58 58 CD cord-010092-uftc8inx 12885 16 cases case NNS cord-010092-uftc8inx 12885 17 were be VBD cord-010092-uftc8inx 12885 18 statistically statistically RB cord-010092-uftc8inx 12885 19 analyzed analyze VBN cord-010092-uftc8inx 12885 20 by by IN cord-010092-uftc8inx 12885 21 the the DT cord-010092-uftc8inx 12885 22 Mann Mann NNP cord-010092-uftc8inx 12885 23 - - HYPH cord-010092-uftc8inx 12885 24 Whitney Whitney NNP cord-010092-uftc8inx 12885 25 test test NN cord-010092-uftc8inx 12885 26 or or CC cord-010092-uftc8inx 12885 27 the the DT cord-010092-uftc8inx 12885 28 Kruskal Kruskal NNP cord-010092-uftc8inx 12885 29 - - HYPH cord-010092-uftc8inx 12885 30 Wallis Wallis NNP cord-010092-uftc8inx 12885 31 test test NN cord-010092-uftc8inx 12885 32 using use VBG cord-010092-uftc8inx 12885 33 Graph Graph NNP cord-010092-uftc8inx 12885 34 - - HYPH cord-010092-uftc8inx 12885 35 Pad pad NN cord-010092-uftc8inx 12885 36 software software NN cord-010092-uftc8inx 12885 37 v5.01 v5.01 NN cord-010092-uftc8inx 12885 38 . . . cord-010092-uftc8inx 12886 1 Results result NNS cord-010092-uftc8inx 12886 2 : : : cord-010092-uftc8inx 12887 1 There there EX cord-010092-uftc8inx 12887 2 was be VBD cord-010092-uftc8inx 12887 3 no no DT cord-010092-uftc8inx 12887 4 significant significant JJ cord-010092-uftc8inx 12887 5 difference difference NN cord-010092-uftc8inx 12887 6 in in IN cord-010092-uftc8inx 12887 7 the the DT cord-010092-uftc8inx 12887 8 time time NN cord-010092-uftc8inx 12887 9 of of IN cord-010092-uftc8inx 12887 10 neutrophil neutrophil NN cord-010092-uftc8inx 12887 11 and and CC cord-010092-uftc8inx 12887 12 platelet platelet NN cord-010092-uftc8inx 12887 13 remodeling remodeling NN cord-010092-uftc8inx 12887 14 , , , cord-010092-uftc8inx 12887 15 the the DT cord-010092-uftc8inx 12887 16 incidence incidence NN cord-010092-uftc8inx 12887 17 of of IN cord-010092-uftc8inx 12887 18 aGVHD aGVHD NNP cord-010092-uftc8inx 12887 19 and and CC cord-010092-uftc8inx 12887 20 the the DT cord-010092-uftc8inx 12887 21 survival survival NN cord-010092-uftc8inx 12887 22 time time NN cord-010092-uftc8inx 12887 23 after after IN cord-010092-uftc8inx 12887 24 transplantation transplantation NN cord-010092-uftc8inx 12887 25 in in IN cord-010092-uftc8inx 12887 26 the the DT cord-010092-uftc8inx 12887 27 KIR KIR NNP cord-010092-uftc8inx 12887 28 genotype genotype NN cord-010092-uftc8inx 12887 29 model model NN cord-010092-uftc8inx 12887 30 . . . cord-010092-uftc8inx 12888 1 In in IN cord-010092-uftc8inx 12888 2 haplotype haplotype NN cord-010092-uftc8inx 12888 3 model model NN cord-010092-uftc8inx 12888 4 , , , cord-010092-uftc8inx 12888 5 there there EX cord-010092-uftc8inx 12888 6 was be VBD cord-010092-uftc8inx 12888 7 no no DT cord-010092-uftc8inx 12888 8 significant significant JJ cord-010092-uftc8inx 12888 9 difference difference NN cord-010092-uftc8inx 12888 10 in in IN cord-010092-uftc8inx 12888 11 neutrophil neutrophil NN cord-010092-uftc8inx 12888 12 and and CC cord-010092-uftc8inx 12888 13 platelet platelet NN cord-010092-uftc8inx 12888 14 remodeling remodeling NN cord-010092-uftc8inx 12888 15 time time NN cord-010092-uftc8inx 12888 16 and and CC cord-010092-uftc8inx 12888 17 survival survival NN cord-010092-uftc8inx 12888 18 time time NN cord-010092-uftc8inx 12888 19 after after IN cord-010092-uftc8inx 12888 20 transplantation transplantation NN cord-010092-uftc8inx 12888 21 . . . cord-010092-uftc8inx 12889 1 The the DT cord-010092-uftc8inx 12889 2 incidence incidence NN cord-010092-uftc8inx 12889 3 of of IN cord-010092-uftc8inx 12889 4 aGVHD aGVHD NNP cord-010092-uftc8inx 12889 5 was be VBD cord-010092-uftc8inx 12889 6 low low JJ cord-010092-uftc8inx 12889 7 when when WRB cord-010092-uftc8inx 12889 8 the the DT cord-010092-uftc8inx 12889 9 KIR KIR NNP cord-010092-uftc8inx 12889 10 haploid haploid NN cord-010092-uftc8inx 12889 11 mismatched mismatch VBN cord-010092-uftc8inx 12889 12 and and CC cord-010092-uftc8inx 12889 13 KIR3DL1 kir3dl1 CD cord-010092-uftc8inx 12889 14 was be VBD cord-010092-uftc8inx 12889 15 positive positive JJ cord-010092-uftc8inx 12889 16 . . . cord-010092-uftc8inx 12890 1 It -PRON- PRP cord-010092-uftc8inx 12890 2 was be VBD cord-010092-uftc8inx 12890 3 conducive conducive JJ cord-010092-uftc8inx 12890 4 to to IN cord-010092-uftc8inx 12890 5 neutrophil neutrophil NN cord-010092-uftc8inx 12890 6 and and CC cord-010092-uftc8inx 12890 7 platelet platelet NN cord-010092-uftc8inx 12890 8 remodeling remodeling NN cord-010092-uftc8inx 12890 9 when when WRB cord-010092-uftc8inx 12890 10 Bw4 bw4 NN cord-010092-uftc8inx 12890 11 / / SYM cord-010092-uftc8inx 12890 12 Bw6 bw6 CD cord-010092-uftc8inx 12890 13 and and CC cord-010092-uftc8inx 12890 14 A3 A3 NNP cord-010092-uftc8inx 12890 15 / / , cord-010092-uftc8inx 12890 16 A11 A11 NNP cord-010092-uftc8inx 12890 17 was be VBD cord-010092-uftc8inx 12890 18 heterozygosity heterozygosity NN cord-010092-uftc8inx 12890 19 . . . cord-010092-uftc8inx 12891 1 Summary Summary NNP cord-010092-uftc8inx 12891 2 / / SYM cord-010092-uftc8inx 12891 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 12892 1 : : : cord-010092-uftc8inx 12892 2 It -PRON- PRP cord-010092-uftc8inx 12892 3 is be VBZ cord-010092-uftc8inx 12892 4 important important JJ cord-010092-uftc8inx 12892 5 to to TO cord-010092-uftc8inx 12892 6 establish establish VB cord-010092-uftc8inx 12892 7 the the DT cord-010092-uftc8inx 12892 8 three three CD cord-010092-uftc8inx 12892 9 different different JJ cord-010092-uftc8inx 12892 10 models model NNS cord-010092-uftc8inx 12892 11 of of IN cord-010092-uftc8inx 12892 12 KIR KIR NNP cord-010092-uftc8inx 12892 13 genotypes genotype NNS cord-010092-uftc8inx 12892 14 , , , cord-010092-uftc8inx 12892 15 haplotypes haplotype NNS cord-010092-uftc8inx 12892 16 and and CC cord-010092-uftc8inx 12892 17 receptor receptor NN cord-010092-uftc8inx 12892 18 - - HYPH cord-010092-uftc8inx 12892 19 ligand ligand NN cord-010092-uftc8inx 12892 20 mismatches mismatch NNS cord-010092-uftc8inx 12892 21 for for IN cord-010092-uftc8inx 12892 22 analyzing analyze VBG cord-010092-uftc8inx 12892 23 the the DT cord-010092-uftc8inx 12892 24 effect effect NN cord-010092-uftc8inx 12892 25 on on IN cord-010092-uftc8inx 12892 26 the the DT cord-010092-uftc8inx 12892 27 prognosis prognosis NN cord-010092-uftc8inx 12892 28 of of IN cord-010092-uftc8inx 12892 29 allo allo NN cord-010092-uftc8inx 12892 30 - - HYPH cord-010092-uftc8inx 12892 31 HSCT HSCT NNP cord-010092-uftc8inx 12892 32 . . . cord-010092-uftc8inx 12893 1 KIR KIR NNP cord-010092-uftc8inx 12893 2 - - HYPH cord-010092-uftc8inx 12893 3 ligand ligand NN cord-010092-uftc8inx 12893 4 model model NN cord-010092-uftc8inx 12893 5 plays play VBZ cord-010092-uftc8inx 12893 6 an an DT cord-010092-uftc8inx 12893 7 important important JJ cord-010092-uftc8inx 12893 8 role role NN cord-010092-uftc8inx 12893 9 in in IN cord-010092-uftc8inx 12893 10 HLA HLA NNP cord-010092-uftc8inx 12893 11 unre unre NNP cord-010092-uftc8inx 12893 12 - - HYPH cord-010092-uftc8inx 12893 13 Background Background NNP cord-010092-uftc8inx 12893 14 : : : cord-010092-uftc8inx 12894 1 Transfusion transfusion NN cord-010092-uftc8inx 12894 2 of of IN cord-010092-uftc8inx 12894 3 platelet platelet NN cord-010092-uftc8inx 12894 4 concentrates concentrate NNS cord-010092-uftc8inx 12894 5 ( ( -LRB- cord-010092-uftc8inx 12894 6 PCs pc NNS cord-010092-uftc8inx 12894 7 ) ) -RRB- cord-010092-uftc8inx 12894 8 has have VBZ cord-010092-uftc8inx 12894 9 been be VBN cord-010092-uftc8inx 12894 10 associated associate VBN cord-010092-uftc8inx 12894 11 with with IN cord-010092-uftc8inx 12894 12 adverse adverse JJ cord-010092-uftc8inx 12894 13 outcomes outcome NNS cord-010092-uftc8inx 12894 14 including include VBG cord-010092-uftc8inx 12894 15 transfusion transfusion NN cord-010092-uftc8inx 12894 16 - - HYPH cord-010092-uftc8inx 12894 17 related relate VBN cord-010092-uftc8inx 12894 18 acute acute JJ cord-010092-uftc8inx 12894 19 lung lung NN cord-010092-uftc8inx 12894 20 injury injury NN cord-010092-uftc8inx 12894 21 ( ( -LRB- cord-010092-uftc8inx 12894 22 TRALI TRALI NNP cord-010092-uftc8inx 12894 23 ) ) -RRB- cord-010092-uftc8inx 12894 24 . . . cord-010092-uftc8inx 12895 1 The the DT cord-010092-uftc8inx 12895 2 underlying underlying JJ cord-010092-uftc8inx 12895 3 mechanism mechanism NN cord-010092-uftc8inx 12895 4 of of IN cord-010092-uftc8inx 12895 5 TRALI TRALI NNP cord-010092-uftc8inx 12895 6 has have VBZ cord-010092-uftc8inx 12895 7 been be VBN cord-010092-uftc8inx 12895 8 related relate VBN cord-010092-uftc8inx 12895 9 to to IN cord-010092-uftc8inx 12895 10 the the DT cord-010092-uftc8inx 12895 11 accumulation accumulation NN cord-010092-uftc8inx 12895 12 of of IN cord-010092-uftc8inx 12895 13 immunomodulatory immunomodulatory JJ cord-010092-uftc8inx 12895 14 mediators mediator NNS cord-010092-uftc8inx 12895 15 ( ( -LRB- cord-010092-uftc8inx 12895 16 e.g. e.g. IN cord-010092-uftc8inx 12895 17 lipids lipid NNS cord-010092-uftc8inx 12895 18 , , , cord-010092-uftc8inx 12895 19 cytokines cytokine NNS cord-010092-uftc8inx 12895 20 / / SYM cord-010092-uftc8inx 12895 21 chemokines chemokine NNS cord-010092-uftc8inx 12895 22 ) ) -RRB- cord-010092-uftc8inx 12895 23 present present JJ cord-010092-uftc8inx 12895 24 in in IN cord-010092-uftc8inx 12895 25 PCs pc NNS cord-010092-uftc8inx 12895 26 . . . cord-010092-uftc8inx 12896 1 Current current JJ cord-010092-uftc8inx 12896 2 room room NN cord-010092-uftc8inx 12896 3 temperature temperature NN cord-010092-uftc8inx 12896 4 storage storage NN cord-010092-uftc8inx 12896 5 limits limit VBZ cord-010092-uftc8inx 12896 6 the the DT cord-010092-uftc8inx 12896 7 shelf shelf NN cord-010092-uftc8inx 12896 8 - - HYPH cord-010092-uftc8inx 12896 9 life life NN cord-010092-uftc8inx 12896 10 of of IN cord-010092-uftc8inx 12896 11 conventional conventional JJ cord-010092-uftc8inx 12896 12 PCs pc NNS cord-010092-uftc8inx 12896 13 to to IN cord-010092-uftc8inx 12896 14 5 5 CD cord-010092-uftc8inx 12896 15 - - SYM cord-010092-uftc8inx 12896 16 7 7 CD cord-010092-uftc8inx 12896 17 days day NNS cord-010092-uftc8inx 12896 18 . . . cord-010092-uftc8inx 12897 1 Alternative alternative JJ cord-010092-uftc8inx 12897 2 storage storage NN cord-010092-uftc8inx 12897 3 conditions condition NNS cord-010092-uftc8inx 12897 4 , , , cord-010092-uftc8inx 12897 5 including include VBG cord-010092-uftc8inx 12897 6 cryopreservation cryopreservation NN cord-010092-uftc8inx 12897 7 , , , cord-010092-uftc8inx 12897 8 offers offer VBZ cord-010092-uftc8inx 12897 9 extended extend VBN cord-010092-uftc8inx 12897 10 storage storage NN cord-010092-uftc8inx 12897 11 and and CC cord-010092-uftc8inx 12897 12 a a DT cord-010092-uftc8inx 12897 13 solution solution NN cord-010092-uftc8inx 12897 14 for for IN cord-010092-uftc8inx 12897 15 blood blood NN cord-010092-uftc8inx 12897 16 banking banking NN cord-010092-uftc8inx 12897 17 logistics logistic NNS cord-010092-uftc8inx 12897 18 . . . cord-010092-uftc8inx 12898 1 Cryopreservation cryopreservation NN cord-010092-uftc8inx 12898 2 of of IN cord-010092-uftc8inx 12898 3 human human JJ cord-010092-uftc8inx 12898 4 PCs pc NNS cord-010092-uftc8inx 12898 5 has have VBZ cord-010092-uftc8inx 12898 6 been be VBN cord-010092-uftc8inx 12898 7 associated associate VBN cord-010092-uftc8inx 12898 8 with with IN cord-010092-uftc8inx 12898 9 higher high JJR cord-010092-uftc8inx 12898 10 concentrations concentration NNS cord-010092-uftc8inx 12898 11 of of IN cord-010092-uftc8inx 12898 12 immunomodulatory immunomodulatory JJ cord-010092-uftc8inx 12898 13 mediators mediator NNS cord-010092-uftc8inx 12898 14 compared compare VBN cord-010092-uftc8inx 12898 15 to to IN cord-010092-uftc8inx 12898 16 room room NN cord-010092-uftc8inx 12898 17 temperature temperature NN cord-010092-uftc8inx 12898 18 stored store VBN cord-010092-uftc8inx 12898 19 PCs pc NNS cord-010092-uftc8inx 12898 20 and and CC cord-010092-uftc8inx 12898 21 it -PRON- PRP cord-010092-uftc8inx 12898 22 has have VBZ cord-010092-uftc8inx 12898 23 been be VBN cord-010092-uftc8inx 12898 24 suggested suggest VBN cord-010092-uftc8inx 12898 25 that that IN cord-010092-uftc8inx 12898 26 cryopreserved cryopreserved JJ cord-010092-uftc8inx 12898 27 PCs pc NNS cord-010092-uftc8inx 12898 28 may may MD cord-010092-uftc8inx 12898 29 be be VB cord-010092-uftc8inx 12898 30 immunomodulatory immunomodulatory JJ cord-010092-uftc8inx 12898 31 . . . cord-010092-uftc8inx 12899 1 To to TO cord-010092-uftc8inx 12899 2 investigate investigate VB cord-010092-uftc8inx 12899 3 the the DT cord-010092-uftc8inx 12899 4 effects effect NNS cord-010092-uftc8inx 12899 5 of of IN cord-010092-uftc8inx 12899 6 cryopreserved cryopreserved JJ cord-010092-uftc8inx 12899 7 PCs pc NNS cord-010092-uftc8inx 12899 8 , , , cord-010092-uftc8inx 12899 9 a a DT cord-010092-uftc8inx 12899 10 transfusion transfusion NN cord-010092-uftc8inx 12899 11 sheep sheep NN cord-010092-uftc8inx 12899 12 model model NN cord-010092-uftc8inx 12899 13 would would MD cord-010092-uftc8inx 12899 14 be be VB cord-010092-uftc8inx 12899 15 a a DT cord-010092-uftc8inx 12899 16 beneficial beneficial JJ cord-010092-uftc8inx 12899 17 approach approach NN cord-010092-uftc8inx 12899 18 . . . cord-010092-uftc8inx 12900 1 Aims aim VBZ cord-010092-uftc8inx 12900 2 : : : cord-010092-uftc8inx 12900 3 To to TO cord-010092-uftc8inx 12900 4 characterize characterize VB cord-010092-uftc8inx 12900 5 immunomodulatory immunomodulatory JJ cord-010092-uftc8inx 12900 6 mediators mediator NNS cord-010092-uftc8inx 12900 7 in in IN cord-010092-uftc8inx 12900 8 supernatants supernatant NNS cord-010092-uftc8inx 12900 9 of of IN cord-010092-uftc8inx 12900 10 sheep sheep NN cord-010092-uftc8inx 12900 11 conventional conventional JJ cord-010092-uftc8inx 12900 12 and and CC cord-010092-uftc8inx 12900 13 cryopreserved cryopreserved JJ cord-010092-uftc8inx 12900 14 PC pc NN cord-010092-uftc8inx 12900 15 and and CC cord-010092-uftc8inx 12900 16 to to TO cord-010092-uftc8inx 12900 17 investigate investigate VB cord-010092-uftc8inx 12900 18 whether whether IN cord-010092-uftc8inx 12900 19 storage storage NN cord-010092-uftc8inx 12900 20 duration duration NN cord-010092-uftc8inx 12900 21 and and CC cord-010092-uftc8inx 12900 22 cryopreservation cryopreservation NN cord-010092-uftc8inx 12900 23 impacts impact VBZ cord-010092-uftc8inx 12900 24 the the DT cord-010092-uftc8inx 12900 25 accumulation accumulation NN cord-010092-uftc8inx 12900 26 of of IN cord-010092-uftc8inx 12900 27 these these DT cord-010092-uftc8inx 12900 28 mediators mediator NNS cord-010092-uftc8inx 12900 29 . . . cord-010092-uftc8inx 12901 1 Methods method NNS cord-010092-uftc8inx 12901 2 : : : cord-010092-uftc8inx 12901 3 Buffy Buffy NNP cord-010092-uftc8inx 12901 4 coat coat NN cord-010092-uftc8inx 12901 5 pooled pool VBD cord-010092-uftc8inx 12901 6 sheep sheep NN cord-010092-uftc8inx 12901 7 PCs pc NNS cord-010092-uftc8inx 12901 8 ( ( -LRB- cord-010092-uftc8inx 12901 9 n n NN cord-010092-uftc8inx 12901 10 = = SYM cord-010092-uftc8inx 12901 11 3 3 CD cord-010092-uftc8inx 12901 12 ) ) -RRB- cord-010092-uftc8inx 12901 13 , , , cord-010092-uftc8inx 12901 14 prepared prepare VBN cord-010092-uftc8inx 12901 15 in in IN cord-010092-uftc8inx 12901 16 30 30 CD cord-010092-uftc8inx 12901 17 % % NN cord-010092-uftc8inx 12901 18 plasma/70 plasma/70 NNP cord-010092-uftc8inx 12901 19 % % NN cord-010092-uftc8inx 12901 20 SSP+ SSP+ NNP cord-010092-uftc8inx 12901 21 with with IN cord-010092-uftc8inx 12901 22 minor minor JJ cord-010092-uftc8inx 12901 23 modifications modification NNS cord-010092-uftc8inx 12901 24 to to IN cord-010092-uftc8inx 12901 25 standard standard JJ cord-010092-uftc8inx 12901 26 human human JJ cord-010092-uftc8inx 12901 27 procedures procedure NNS cord-010092-uftc8inx 12901 28 , , , cord-010092-uftc8inx 12901 29 were be VBD cord-010092-uftc8inx 12901 30 stored store VBN cord-010092-uftc8inx 12901 31 room room NN cord-010092-uftc8inx 12901 32 temperature temperature NN cord-010092-uftc8inx 12901 33 ( ( -LRB- cord-010092-uftc8inx 12901 34 RT RT NNP cord-010092-uftc8inx 12901 35 ) ) -RRB- cord-010092-uftc8inx 12901 36 for for IN cord-010092-uftc8inx 12901 37 7 7 CD cord-010092-uftc8inx 12901 38 days day NNS cord-010092-uftc8inx 12901 39 ( ( -LRB- cord-010092-uftc8inx 12901 40 D D NNP cord-010092-uftc8inx 12901 41 ) ) -RRB- cord-010092-uftc8inx 12901 42 and and CC cord-010092-uftc8inx 12901 43 sampled sample VBN cord-010092-uftc8inx 12901 44 on on IN cord-010092-uftc8inx 12901 45 D2 d2 NN cord-010092-uftc8inx 12901 46 , , , cord-010092-uftc8inx 12901 47 D5 D5 NNP cord-010092-uftc8inx 12901 48 and and CC cord-010092-uftc8inx 12901 49 D7 D7 NNP cord-010092-uftc8inx 12901 50 . . . cord-010092-uftc8inx 12902 1 Cryopreserved cryopreserved JJ cord-010092-uftc8inx 12902 2 sheep sheep NN cord-010092-uftc8inx 12902 3 PCs pc NNS cord-010092-uftc8inx 12902 4 ( ( -LRB- cord-010092-uftc8inx 12902 5 n n NN cord-010092-uftc8inx 12902 6 = = SYM cord-010092-uftc8inx 12902 7 3 3 CD cord-010092-uftc8inx 12902 8 ) ) -RRB- cord-010092-uftc8inx 12902 9 , , , cord-010092-uftc8inx 12902 10 prepared prepare VBN cord-010092-uftc8inx 12902 11 by by IN cord-010092-uftc8inx 12902 12 the the DT cord-010092-uftc8inx 12902 13 addition addition NN cord-010092-uftc8inx 12902 14 of of IN cord-010092-uftc8inx 12902 15 5 5 CD cord-010092-uftc8inx 12902 16 - - SYM cord-010092-uftc8inx 12902 17 6 6 CD cord-010092-uftc8inx 12902 18 % % NN cord-010092-uftc8inx 12902 19 dimethyl dimethyl NN cord-010092-uftc8inx 12902 20 sulfoxide sulfoxide NN cord-010092-uftc8inx 12902 21 , , , cord-010092-uftc8inx 12902 22 were be VBD cord-010092-uftc8inx 12902 23 stored store VBN cord-010092-uftc8inx 12902 24 at at IN cord-010092-uftc8inx 12902 25 À80 À80 NNP cord-010092-uftc8inx 12902 26 ° ° NN cord-010092-uftc8inx 12902 27 C c NN cord-010092-uftc8inx 12902 28 and and CC cord-010092-uftc8inx 12902 29 sampled sample VBN cord-010092-uftc8inx 12902 30 pre pre JJ cord-010092-uftc8inx 12902 31 - - JJ cord-010092-uftc8inx 12902 32 freeze freeze VB cord-010092-uftc8inx 12902 33 and and CC cord-010092-uftc8inx 12902 34 post post NN cord-010092-uftc8inx 12902 35 - - NN cord-010092-uftc8inx 12902 36 thaw thaw NN cord-010092-uftc8inx 12902 37 . . . cord-010092-uftc8inx 12903 1 Supernatant Supernatant NNP cord-010092-uftc8inx 12903 2 was be VBD cord-010092-uftc8inx 12903 3 prepared prepare VBN cord-010092-uftc8inx 12903 4 at at IN cord-010092-uftc8inx 12903 5 each each DT cord-010092-uftc8inx 12903 6 time time NN cord-010092-uftc8inx 12903 7 point point NN cord-010092-uftc8inx 12903 8 with with IN cord-010092-uftc8inx 12903 9 double double JJ cord-010092-uftc8inx 12903 10 centrifugation centrifugation NN cord-010092-uftc8inx 12903 11 and and CC cord-010092-uftc8inx 12903 12 stored store VBN cord-010092-uftc8inx 12903 13 at at IN cord-010092-uftc8inx 12903 14 À80 À80 NNP cord-010092-uftc8inx 12903 15 ° ° NN cord-010092-uftc8inx 12903 16 C C NNP cord-010092-uftc8inx 12903 17 . . . cord-010092-uftc8inx 12904 1 Concentrations concentration NNS cord-010092-uftc8inx 12904 2 of of IN cord-010092-uftc8inx 12904 3 pro pro JJ cord-010092-uftc8inx 12904 4 - - JJ cord-010092-uftc8inx 12904 5 inflammatory inflammatory JJ cord-010092-uftc8inx 12904 6 cytokines cytokine NNS cord-010092-uftc8inx 12904 7 ( ( -LRB- cord-010092-uftc8inx 12904 8 interleukin interleukin FW cord-010092-uftc8inx 12904 9 ( ( -LRB- cord-010092-uftc8inx 12904 10 IL)-6 IL)-6 NNP cord-010092-uftc8inx 12904 11 , , , cord-010092-uftc8inx 12904 12 IL-1b IL-1b NNP cord-010092-uftc8inx 12904 13 , , , cord-010092-uftc8inx 12904 14 IL-17A IL-17A NNP cord-010092-uftc8inx 12904 15 ) ) -RRB- cord-010092-uftc8inx 12904 16 , , , cord-010092-uftc8inx 12904 17 anti anti JJ cord-010092-uftc8inx 12904 18 - - JJ cord-010092-uftc8inx 12904 19 inflammatory inflammatory JJ cord-010092-uftc8inx 12904 20 cytokine cytokine NN cord-010092-uftc8inx 12904 21 IL-10 IL-10 NNP cord-010092-uftc8inx 12904 22 and and CC cord-010092-uftc8inx 12904 23 chemokines chemokine NNS cord-010092-uftc8inx 12904 24 ( ( -LRB- cord-010092-uftc8inx 12904 25 IL-8 IL-8 NNP cord-010092-uftc8inx 12904 26 , , , cord-010092-uftc8inx 12904 27 monokine monokine NN cord-010092-uftc8inx 12904 28 induced induce VBN cord-010092-uftc8inx 12904 29 by by IN cord-010092-uftc8inx 12904 30 gamma gamma NN cord-010092-uftc8inx 12904 31 interferon interferon NN cord-010092-uftc8inx 12904 32 ( ( -LRB- cord-010092-uftc8inx 12904 33 MIG MIG NNP cord-010092-uftc8inx 12904 34 ) ) -RRB- cord-010092-uftc8inx 12904 35 and and CC cord-010092-uftc8inx 12904 36 interferongamma interferongamma NNP cord-010092-uftc8inx 12904 37 induced induce VBD cord-010092-uftc8inx 12904 38 protein protein NNP cord-010092-uftc8inx 12904 39 ( ( -LRB- cord-010092-uftc8inx 12904 40 IP)-10 IP)-10 NNP cord-010092-uftc8inx 12904 41 ) ) -RRB- cord-010092-uftc8inx 12904 42 were be VBD cord-010092-uftc8inx 12904 43 measured measure VBN cord-010092-uftc8inx 12904 44 using use VBG cord-010092-uftc8inx 12904 45 sheep sheep NN cord-010092-uftc8inx 12904 46 specific specific JJ cord-010092-uftc8inx 12904 47 in in IN cord-010092-uftc8inx 12904 48 - - HYPH cord-010092-uftc8inx 12904 49 house house NN cord-010092-uftc8inx 12904 50 and and CC cord-010092-uftc8inx 12904 51 commercial commercial JJ cord-010092-uftc8inx 12904 52 enzyme enzyme NN cord-010092-uftc8inx 12904 53 linked link VBN cord-010092-uftc8inx 12904 54 immunoassays immunoassays NNP cord-010092-uftc8inx 12904 55 ( ( -LRB- cord-010092-uftc8inx 12904 56 ELISA ELISA NNP cord-010092-uftc8inx 12904 57 ) ) -RRB- cord-010092-uftc8inx 12904 58 . . . cord-010092-uftc8inx 12905 1 Levels level NNS cord-010092-uftc8inx 12905 2 of of IN cord-010092-uftc8inx 12905 3 non non JJ cord-010092-uftc8inx 12905 4 - - JJ cord-010092-uftc8inx 12905 5 polar polar JJ cord-010092-uftc8inx 12905 6 lipid lipid NN cord-010092-uftc8inx 12905 7 mediators mediator NNS cord-010092-uftc8inx 12905 8 , , , cord-010092-uftc8inx 12905 9 such such JJ cord-010092-uftc8inx 12905 10 as as IN cord-010092-uftc8inx 12905 11 arachidonic arachidonic JJ cord-010092-uftc8inx 12905 12 acid acid NN cord-010092-uftc8inx 12905 13 ( ( -LRB- cord-010092-uftc8inx 12905 14 AA AA NNP cord-010092-uftc8inx 12905 15 ) ) -RRB- cord-010092-uftc8inx 12905 16 , , , cord-010092-uftc8inx 12905 17 12-HETE 12-hete CD cord-010092-uftc8inx 12905 18 and and CC cord-010092-uftc8inx 12905 19 15-HETE 15-hete CD cord-010092-uftc8inx 12905 20 were be VBD cord-010092-uftc8inx 12905 21 assessed assess VBN cord-010092-uftc8inx 12905 22 in in IN cord-010092-uftc8inx 12905 23 the the DT cord-010092-uftc8inx 12905 24 stored store VBN cord-010092-uftc8inx 12905 25 sheep sheep NN cord-010092-uftc8inx 12905 26 PC pc NN cord-010092-uftc8inx 12905 27 - - : cord-010092-uftc8inx 12905 28 and and CC cord-010092-uftc8inx 12905 29 cryo cryo NN cord-010092-uftc8inx 12905 30 - - HYPH cord-010092-uftc8inx 12905 31 PC pc NN cord-010092-uftc8inx 12905 32 supernatant supernatant NN cord-010092-uftc8inx 12905 33 using use VBG cord-010092-uftc8inx 12905 34 commercial commercial JJ cord-010092-uftc8inx 12905 35 ELISA ELISA NNP cord-010092-uftc8inx 12905 36 . . . cord-010092-uftc8inx 12906 1 Results result NNS cord-010092-uftc8inx 12906 2 shown show VBN cord-010092-uftc8inx 12906 3 as as IN cord-010092-uftc8inx 12906 4 mean mean JJ cord-010092-uftc8inx 12906 5 AE AE NNP cord-010092-uftc8inx 12906 6 standard standard JJ cord-010092-uftc8inx 12906 7 deviation deviation NN cord-010092-uftc8inx 12906 8 . . . cord-010092-uftc8inx 12907 1 The the DT cord-010092-uftc8inx 12907 2 effect effect NN cord-010092-uftc8inx 12907 3 of of IN cord-010092-uftc8inx 12907 4 storage storage NN cord-010092-uftc8inx 12907 5 was be VBD cord-010092-uftc8inx 12907 6 determined determine VBN cord-010092-uftc8inx 12907 7 at at IN cord-010092-uftc8inx 12907 8 P p NN cord-010092-uftc8inx 12907 9 < < XX cord-010092-uftc8inx 12907 10 0.05 0.05 CD cord-010092-uftc8inx 12907 11 using use VBG cord-010092-uftc8inx 12907 12 paired pair VBN cord-010092-uftc8inx 12907 13 t t NN cord-010092-uftc8inx 12907 14 - - HYPH cord-010092-uftc8inx 12907 15 test test NN cord-010092-uftc8inx 12907 16 . . . cord-010092-uftc8inx 12908 1 Results result NNS cord-010092-uftc8inx 12908 2 : : : cord-010092-uftc8inx 12909 1 In in IN cord-010092-uftc8inx 12909 2 RT RT NNP cord-010092-uftc8inx 12909 3 stored store VBD cord-010092-uftc8inx 12909 4 sheep sheep NN cord-010092-uftc8inx 12909 5 PC pc NN cord-010092-uftc8inx 12909 6 supernatant supernatant VBN cord-010092-uftc8inx 12909 7 IL-6 IL-6 NNP cord-010092-uftc8inx 12909 8 , , , cord-010092-uftc8inx 12909 9 IL-1b IL-1b NNP cord-010092-uftc8inx 12909 10 , , , cord-010092-uftc8inx 12909 11 IL-17A IL-17A NNP cord-010092-uftc8inx 12909 12 , , , cord-010092-uftc8inx 12909 13 IL-10 IL-10 NNP cord-010092-uftc8inx 12909 14 , , , cord-010092-uftc8inx 12909 15 IL-8 IL-8 NNP cord-010092-uftc8inx 12909 16 , , , cord-010092-uftc8inx 12909 17 MIG MIG NNP cord-010092-uftc8inx 12909 18 , , , cord-010092-uftc8inx 12909 19 IP-10 IP-10 NNP cord-010092-uftc8inx 12909 20 , , , cord-010092-uftc8inx 12909 21 12-HETE 12-HETE NNP cord-010092-uftc8inx 12909 22 and and CC cord-010092-uftc8inx 12909 23 15-HETE 15-hete CD cord-010092-uftc8inx 12909 24 were be VBD cord-010092-uftc8inx 12909 25 detected detect VBN cord-010092-uftc8inx 12909 26 at at IN cord-010092-uftc8inx 12909 27 D2 d2 NN cord-010092-uftc8inx 12909 28 , , , cord-010092-uftc8inx 12909 29 D5 D5 NNP cord-010092-uftc8inx 12909 30 and and CC cord-010092-uftc8inx 12909 31 D7 D7 NNP cord-010092-uftc8inx 12909 32 . . . cord-010092-uftc8inx 12910 1 Storage storage NN cord-010092-uftc8inx 12910 2 duration duration NN cord-010092-uftc8inx 12910 3 significantly significantly RB cord-010092-uftc8inx 12910 4 increased increase VBD cord-010092-uftc8inx 12910 5 accumulation accumulation NN cord-010092-uftc8inx 12910 6 of of IN cord-010092-uftc8inx 12910 7 IP-10 IP-10 NNP cord-010092-uftc8inx 12910 8 at at IN cord-010092-uftc8inx 12910 9 D5 D5 NNP cord-010092-uftc8inx 12910 10 ( ( -LRB- cord-010092-uftc8inx 12910 11 253.4 253.4 CD cord-010092-uftc8inx 12910 12 AE AE NNP cord-010092-uftc8inx 12910 13 266.7 266.7 CD cord-010092-uftc8inx 12910 14 pg pg NN cord-010092-uftc8inx 12910 15 / / SYM cord-010092-uftc8inx 12910 16 mL ml NN cord-010092-uftc8inx 12910 17 compared compare VBN cord-010092-uftc8inx 12910 18 to to IN cord-010092-uftc8inx 12910 19 569.7 569.7 CD cord-010092-uftc8inx 12910 20 AE AE NNP cord-010092-uftc8inx 12910 21 272.7 272.7 CD cord-010092-uftc8inx 12910 22 pg pg NN cord-010092-uftc8inx 12910 23 / / SYM cord-010092-uftc8inx 12910 24 mL ml NN cord-010092-uftc8inx 12910 25 , , , cord-010092-uftc8inx 12910 26 P p NN cord-010092-uftc8inx 12910 27 = = SYM cord-010092-uftc8inx 12910 28 0.008 0.008 CD cord-010092-uftc8inx 12910 29 ) ) -RRB- cord-010092-uftc8inx 12910 30 and and CC cord-010092-uftc8inx 12910 31 further further RB cord-010092-uftc8inx 12910 32 increased increase VBD cord-010092-uftc8inx 12910 33 at at IN cord-010092-uftc8inx 12910 34 D7 D7 NNP cord-010092-uftc8inx 12910 35 , , , cord-010092-uftc8inx 12910 36 and and CC cord-010092-uftc8inx 12910 37 IL-8 IL-8 NNP cord-010092-uftc8inx 12910 38 at at IN cord-010092-uftc8inx 12910 39 D7 D7 NNP cord-010092-uftc8inx 12910 40 ( ( -LRB- cord-010092-uftc8inx 12910 41 3477 3477 CD cord-010092-uftc8inx 12910 42 AE AE NNP cord-010092-uftc8inx 12910 43 937.4 937.4 CD cord-010092-uftc8inx 12910 44 pg pg NN cord-010092-uftc8inx 12910 45 / / SYM cord-010092-uftc8inx 12910 46 mL ml NN cord-010092-uftc8inx 12911 1 compared compare VBN cord-010092-uftc8inx 12911 2 to to IN cord-010092-uftc8inx 12911 3 5092 5092 CD cord-010092-uftc8inx 12911 4 AE AE NNP cord-010092-uftc8inx 12911 5 521.1 521.1 CD cord-010092-uftc8inx 12911 6 pg pg NN cord-010092-uftc8inx 12911 7 / / SYM cord-010092-uftc8inx 12911 8 mL ml NN cord-010092-uftc8inx 12911 9 , , , cord-010092-uftc8inx 12911 10 P p NN cord-010092-uftc8inx 12911 11 = = SYM cord-010092-uftc8inx 12911 12 0.0460 0.0460 CD cord-010092-uftc8inx 12911 13 ) ) -RRB- cord-010092-uftc8inx 12911 14 . . . cord-010092-uftc8inx 12912 1 Cryopreserved Cryopreserved NNP cord-010092-uftc8inx 12912 2 sheep sheep NN cord-010092-uftc8inx 12912 3 PC pc NN cord-010092-uftc8inx 12912 4 supernatant supernatant NN cord-010092-uftc8inx 12912 5 pre pre JJ cord-010092-uftc8inx 12912 6 - - JJ cord-010092-uftc8inx 12912 7 freeze freeze VB cord-010092-uftc8inx 12912 8 and and CC cord-010092-uftc8inx 12912 9 post post NN cord-010092-uftc8inx 12912 10 - - NN cord-010092-uftc8inx 12912 11 thaw thaw NN cord-010092-uftc8inx 12912 12 contained contain VBN cord-010092-uftc8inx 12912 13 equivalent equivalent JJ cord-010092-uftc8inx 12912 14 or or CC cord-010092-uftc8inx 12912 15 higher high JJR cord-010092-uftc8inx 12912 16 concentrations concentration NNS cord-010092-uftc8inx 12912 17 of of IN cord-010092-uftc8inx 12912 18 IL-6 IL-6 NNP cord-010092-uftc8inx 12912 19 , , , cord-010092-uftc8inx 12912 20 IL-1b IL-1b NNP cord-010092-uftc8inx 12912 21 , , , cord-010092-uftc8inx 12912 22 IL-17A IL-17A NNP cord-010092-uftc8inx 12912 23 , , , cord-010092-uftc8inx 12912 24 IL-10 IL-10 NNP cord-010092-uftc8inx 12912 25 , , , cord-010092-uftc8inx 12912 26 IL-8 IL-8 NNP cord-010092-uftc8inx 12912 27 , , , cord-010092-uftc8inx 12912 28 MIG MIG NNP cord-010092-uftc8inx 12912 29 , , , cord-010092-uftc8inx 12912 30 IP-10 IP-10 NNP cord-010092-uftc8inx 12912 31 , , , cord-010092-uftc8inx 12912 32 12-HETE 12-hete CD cord-010092-uftc8inx 12912 33 and and CC cord-010092-uftc8inx 12912 34 15-HETE 15-hete CD cord-010092-uftc8inx 12912 35 than than IN cord-010092-uftc8inx 12912 36 RT RT NNP cord-010092-uftc8inx 12912 37 stored store VBD cord-010092-uftc8inx 12912 38 D5 D5 NNP cord-010092-uftc8inx 12912 39 PCs pc NNS cord-010092-uftc8inx 12912 40 . . . cord-010092-uftc8inx 12913 1 However however RB cord-010092-uftc8inx 12913 2 , , , cord-010092-uftc8inx 12913 3 cryopreservation cryopreservation NN cord-010092-uftc8inx 12913 4 did do VBD cord-010092-uftc8inx 12913 5 not not RB cord-010092-uftc8inx 12913 6 impact impact NN cord-010092-uftc8inx 12913 7 levels level NNS cord-010092-uftc8inx 12913 8 of of IN cord-010092-uftc8inx 12913 9 any any DT cord-010092-uftc8inx 12913 10 of of IN cord-010092-uftc8inx 12913 11 the the DT cord-010092-uftc8inx 12913 12 platelet platelet NN cord-010092-uftc8inx 12913 13 derived derive VBN cord-010092-uftc8inx 12913 14 mediators mediator NNS cord-010092-uftc8inx 12913 15 . . . cord-010092-uftc8inx 12914 1 Summary Summary NNP cord-010092-uftc8inx 12914 2 / / SYM cord-010092-uftc8inx 12914 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 12914 4 : : : cord-010092-uftc8inx 12915 1 Several several JJ cord-010092-uftc8inx 12915 2 platelet platelet NN cord-010092-uftc8inx 12915 3 - - HYPH cord-010092-uftc8inx 12915 4 derived derive VBN cord-010092-uftc8inx 12915 5 cytokines cytokine NNS cord-010092-uftc8inx 12915 6 / / SYM cord-010092-uftc8inx 12915 7 chemokines chemokine NNS cord-010092-uftc8inx 12915 8 , , , cord-010092-uftc8inx 12915 9 including include VBG cord-010092-uftc8inx 12915 10 high high JJ cord-010092-uftc8inx 12915 11 concentration concentration NN cord-010092-uftc8inx 12915 12 of of IN cord-010092-uftc8inx 12915 13 IL-8 il-8 NN cord-010092-uftc8inx 12915 14 with with IN cord-010092-uftc8inx 12915 15 neutrophil neutrophil NN cord-010092-uftc8inx 12915 16 priming priming NN cord-010092-uftc8inx 12915 17 activity activity NN cord-010092-uftc8inx 12915 18 , , , cord-010092-uftc8inx 12915 19 and and CC cord-010092-uftc8inx 12915 20 non non JJ cord-010092-uftc8inx 12915 21 - - JJ cord-010092-uftc8inx 12915 22 polar polar JJ cord-010092-uftc8inx 12915 23 lipids lipid NNS cord-010092-uftc8inx 12915 24 were be VBD cord-010092-uftc8inx 12915 25 found find VBN cord-010092-uftc8inx 12915 26 in in IN cord-010092-uftc8inx 12915 27 stored store VBN cord-010092-uftc8inx 12915 28 sheep sheep NN cord-010092-uftc8inx 12915 29 PC pc NN cord-010092-uftc8inx 12915 30 supernatant supernatant JJ cord-010092-uftc8inx 12915 31 . . . cord-010092-uftc8inx 12916 1 These these DT cord-010092-uftc8inx 12916 2 immunomodulatory immunomodulatory JJ cord-010092-uftc8inx 12916 3 mediators mediator NNS cord-010092-uftc8inx 12916 4 may may MD cord-010092-uftc8inx 12916 5 contribute contribute VB cord-010092-uftc8inx 12916 6 to to IN cord-010092-uftc8inx 12916 7 adverse adverse JJ cord-010092-uftc8inx 12916 8 outcomes outcome NNS cord-010092-uftc8inx 12916 9 associated associate VBN cord-010092-uftc8inx 12916 10 with with IN cord-010092-uftc8inx 12916 11 PC pc NN cord-010092-uftc8inx 12916 12 transfusion transfusion NN cord-010092-uftc8inx 12916 13 . . . cord-010092-uftc8inx 12917 1 Storage storage NN cord-010092-uftc8inx 12917 2 at at IN cord-010092-uftc8inx 12917 3 RT RT NNP cord-010092-uftc8inx 12917 4 , , , cord-010092-uftc8inx 12917 5 but but CC cord-010092-uftc8inx 12917 6 not not RB cord-010092-uftc8inx 12917 7 cryopreservation cryopreservation NN cord-010092-uftc8inx 12917 8 was be VBD cord-010092-uftc8inx 12917 9 associated associate VBN cord-010092-uftc8inx 12917 10 with with IN cord-010092-uftc8inx 12917 11 increased increase VBN cord-010092-uftc8inx 12917 12 accumulation accumulation NN cord-010092-uftc8inx 12917 13 of of IN cord-010092-uftc8inx 12917 14 immunomodulatory immunomodulatory JJ cord-010092-uftc8inx 12917 15 mediators mediator NNS cord-010092-uftc8inx 12917 16 in in IN cord-010092-uftc8inx 12917 17 sheep sheep NN cord-010092-uftc8inx 12917 18 PCs pc NNS cord-010092-uftc8inx 12917 19 . . . cord-010092-uftc8inx 12918 1 Most most RBS cord-010092-uftc8inx 12918 2 importantly importantly RB cord-010092-uftc8inx 12918 3 , , , cord-010092-uftc8inx 12918 4 similar similar JJ cord-010092-uftc8inx 12918 5 to to IN cord-010092-uftc8inx 12918 6 human human JJ cord-010092-uftc8inx 12918 7 PCs pc NNS cord-010092-uftc8inx 12918 8 , , , cord-010092-uftc8inx 12918 9 sheep sheep NNS cord-010092-uftc8inx 12918 10 cryopreserved cryopreserve VBD cord-010092-uftc8inx 12918 11 PCs pc NNS cord-010092-uftc8inx 12918 12 contained contain VBD cord-010092-uftc8inx 12918 13 at at IN cord-010092-uftc8inx 12918 14 least least JJS cord-010092-uftc8inx 12918 15 if if IN cord-010092-uftc8inx 12918 16 not not RB cord-010092-uftc8inx 12918 17 higher high JJR cord-010092-uftc8inx 12918 18 concentrations concentration NNS cord-010092-uftc8inx 12918 19 of of IN cord-010092-uftc8inx 12918 20 majority majority NN cord-010092-uftc8inx 12918 21 of of IN cord-010092-uftc8inx 12918 22 cytokines cytokine NNS cord-010092-uftc8inx 12918 23 as as IN cord-010092-uftc8inx 12918 24 PCs pc NNS cord-010092-uftc8inx 12918 25 stored store VBN cord-010092-uftc8inx 12918 26 at at IN cord-010092-uftc8inx 12918 27 RT RT NNP cord-010092-uftc8inx 12918 28 , , , cord-010092-uftc8inx 12918 29 therefore therefore RB cord-010092-uftc8inx 12918 30 making make VBG cord-010092-uftc8inx 12918 31 sheep sheep NNS cord-010092-uftc8inx 12918 32 a a DT cord-010092-uftc8inx 12918 33 suitable suitable JJ cord-010092-uftc8inx 12918 34 model model NN cord-010092-uftc8inx 12918 35 in in IN cord-010092-uftc8inx 12918 36 which which WDT cord-010092-uftc8inx 12918 37 to to TO cord-010092-uftc8inx 12918 38 investigate investigate VB cord-010092-uftc8inx 12918 39 immunomodulatory immunomodulatory JJ cord-010092-uftc8inx 12918 40 effects effect NNS cord-010092-uftc8inx 12918 41 of of IN cord-010092-uftc8inx 12918 42 cryopreserved cryopreserved JJ cord-010092-uftc8inx 12918 43 PC pc NN cord-010092-uftc8inx 12918 44 transfusion transfusion NN cord-010092-uftc8inx 12918 45 . . . cord-010092-uftc8inx 12919 1 Background background NN cord-010092-uftc8inx 12919 2 : : : cord-010092-uftc8inx 12920 1 Transfusion transfusion NN cord-010092-uftc8inx 12920 2 , , , cord-010092-uftc8inx 12920 3 despite despite IN cord-010092-uftc8inx 12920 4 being be VBG cord-010092-uftc8inx 12920 5 a a DT cord-010092-uftc8inx 12920 6 lifesaving lifesave VBG cord-010092-uftc8inx 12920 7 therapy therapy NN cord-010092-uftc8inx 12920 8 , , , cord-010092-uftc8inx 12920 9 has have VBZ cord-010092-uftc8inx 12920 10 been be VBN cord-010092-uftc8inx 12920 11 associated associate VBN cord-010092-uftc8inx 12920 12 with with IN cord-010092-uftc8inx 12920 13 adverse adverse JJ cord-010092-uftc8inx 12920 14 transfusion transfusion NN cord-010092-uftc8inx 12920 15 outcomes outcome NNS cord-010092-uftc8inx 12920 16 . . . cord-010092-uftc8inx 12921 1 Transfusion transfusion NN cord-010092-uftc8inx 12921 2 related relate VBD cord-010092-uftc8inx 12921 3 acute acute JJ cord-010092-uftc8inx 12921 4 lung lung NN cord-010092-uftc8inx 12921 5 injury injury NN cord-010092-uftc8inx 12921 6 ( ( -LRB- cord-010092-uftc8inx 12921 7 TRALI TRALI NNP cord-010092-uftc8inx 12921 8 ) ) -RRB- cord-010092-uftc8inx 12921 9 remains remain VBZ cord-010092-uftc8inx 12921 10 one one CD cord-010092-uftc8inx 12921 11 of of IN cord-010092-uftc8inx 12921 12 the the DT cord-010092-uftc8inx 12921 13 leading lead VBG cord-010092-uftc8inx 12921 14 causes cause NNS cord-010092-uftc8inx 12921 15 of of IN cord-010092-uftc8inx 12921 16 transfusion transfusion NN cord-010092-uftc8inx 12921 17 - - HYPH cord-010092-uftc8inx 12921 18 related relate VBN cord-010092-uftc8inx 12921 19 mortality mortality NN cord-010092-uftc8inx 12921 20 . . . cord-010092-uftc8inx 12922 1 Accumulation accumulation NN cord-010092-uftc8inx 12922 2 of of IN cord-010092-uftc8inx 12922 3 immunomodulatory immunomodulatory JJ cord-010092-uftc8inx 12922 4 mediators mediator NNS cord-010092-uftc8inx 12922 5 ( ( -LRB- cord-010092-uftc8inx 12922 6 e.g. e.g. IN cord-010092-uftc8inx 12922 7 lipids lipid NNS cord-010092-uftc8inx 12922 8 , , , cord-010092-uftc8inx 12922 9 cytokines cytokine NNS cord-010092-uftc8inx 12922 10 / / SYM cord-010092-uftc8inx 12922 11 chemokines chemokine NNS cord-010092-uftc8inx 12922 12 ) ) -RRB- cord-010092-uftc8inx 12922 13 present present VBP cord-010092-uftc8inx 12922 14 in in IN cord-010092-uftc8inx 12922 15 blood blood NN cord-010092-uftc8inx 12922 16 products product NNS cord-010092-uftc8inx 12922 17 , , , cord-010092-uftc8inx 12922 18 including include VBG cord-010092-uftc8inx 12922 19 packed pack VBN cord-010092-uftc8inx 12922 20 red red JJ cord-010092-uftc8inx 12922 21 blood blood NN cord-010092-uftc8inx 12922 22 cells cell NNS cord-010092-uftc8inx 12922 23 ( ( -LRB- cord-010092-uftc8inx 12922 24 PRBCs prbc NNS cord-010092-uftc8inx 12922 25 ) ) -RRB- cord-010092-uftc8inx 12922 26 , , , cord-010092-uftc8inx 12922 27 have have VBP cord-010092-uftc8inx 12922 28 been be VBN cord-010092-uftc8inx 12922 29 implicated implicate VBN cord-010092-uftc8inx 12922 30 with with IN cord-010092-uftc8inx 12922 31 the the DT cord-010092-uftc8inx 12922 32 development development NN cord-010092-uftc8inx 12922 33 of of IN cord-010092-uftc8inx 12922 34 non non JJ cord-010092-uftc8inx 12922 35 - - JJ cord-010092-uftc8inx 12922 36 antibody antibody JJ cord-010092-uftc8inx 12922 37 mediated mediate VBN cord-010092-uftc8inx 12922 38 TRALI TRALI NNP cord-010092-uftc8inx 12922 39 . . . cord-010092-uftc8inx 12923 1 However however RB cord-010092-uftc8inx 12923 2 , , , cord-010092-uftc8inx 12923 3 how how WRB cord-010092-uftc8inx 12923 4 specific specific JJ cord-010092-uftc8inx 12923 5 mediators mediator NNS cord-010092-uftc8inx 12923 6 contribute contribute VBP cord-010092-uftc8inx 12923 7 to to IN cord-010092-uftc8inx 12923 8 the the DT cord-010092-uftc8inx 12923 9 underlying underlying JJ cord-010092-uftc8inx 12923 10 mechanism mechanism NN cord-010092-uftc8inx 12923 11 is be VBZ cord-010092-uftc8inx 12923 12 yet yet RB cord-010092-uftc8inx 12923 13 to to TO cord-010092-uftc8inx 12923 14 be be VB cord-010092-uftc8inx 12923 15 defined define VBN cord-010092-uftc8inx 12923 16 . . . cord-010092-uftc8inx 12924 1 During during IN cord-010092-uftc8inx 12924 2 routine routine JJ cord-010092-uftc8inx 12924 3 storage storage NN cord-010092-uftc8inx 12924 4 of of IN cord-010092-uftc8inx 12924 5 human human JJ cord-010092-uftc8inx 12924 6 PRBCs prbc NNS cord-010092-uftc8inx 12924 7 fewer few JJR cord-010092-uftc8inx 12924 8 than than IN cord-010092-uftc8inx 12924 9 10 10 CD cord-010092-uftc8inx 12924 10 cytokines cytokine NNS cord-010092-uftc8inx 12924 11 / / SYM cord-010092-uftc8inx 12924 12 chemokines chemokine NNS cord-010092-uftc8inx 12924 13 and and CC cord-010092-uftc8inx 12924 14 several several JJ cord-010092-uftc8inx 12924 15 biologically biologically RB cord-010092-uftc8inx 12924 16 active active JJ cord-010092-uftc8inx 12924 17 lipids lipid NNS cord-010092-uftc8inx 12924 18 have have VBP cord-010092-uftc8inx 12924 19 been be VBN cord-010092-uftc8inx 12924 20 identified identify VBN cord-010092-uftc8inx 12924 21 . . . cord-010092-uftc8inx 12925 1 A a DT cord-010092-uftc8inx 12925 2 sheep sheep NN cord-010092-uftc8inx 12925 3 model model NN cord-010092-uftc8inx 12925 4 of of IN cord-010092-uftc8inx 12925 5 TRALI TRALI NNP cord-010092-uftc8inx 12925 6 has have VBZ cord-010092-uftc8inx 12925 7 successfully successfully RB cord-010092-uftc8inx 12925 8 been be VBN cord-010092-uftc8inx 12925 9 developed develop VBN cord-010092-uftc8inx 12925 10 using use VBG cord-010092-uftc8inx 12925 11 human human JJ cord-010092-uftc8inx 12925 12 PRBC PRBC NNP cord-010092-uftc8inx 12925 13 supernatant supernatant NN cord-010092-uftc8inx 12925 14 , , , cord-010092-uftc8inx 12925 15 however however RB cord-010092-uftc8inx 12925 16 transfusing transfuse VBG cord-010092-uftc8inx 12925 17 sheep sheep NN cord-010092-uftc8inx 12925 18 PRBC PRBC NNP cord-010092-uftc8inx 12925 19 has have VBZ cord-010092-uftc8inx 12925 20 not not RB cord-010092-uftc8inx 12925 21 been be VBN cord-010092-uftc8inx 12925 22 investigated investigate VBN cord-010092-uftc8inx 12925 23 . . . cord-010092-uftc8inx 12926 1 To to TO cord-010092-uftc8inx 12926 2 support support VB cord-010092-uftc8inx 12926 3 the the DT cord-010092-uftc8inx 12926 4 use use NN cord-010092-uftc8inx 12926 5 of of IN cord-010092-uftc8inx 12926 6 sheep sheep NN cord-010092-uftc8inx 12926 7 PRBC PRBC NNP cord-010092-uftc8inx 12926 8 in in IN cord-010092-uftc8inx 12926 9 the the DT cord-010092-uftc8inx 12926 10 TRALI TRALI NNP cord-010092-uftc8inx 12926 11 model model NN cord-010092-uftc8inx 12926 12 and and CC cord-010092-uftc8inx 12926 13 to to TO cord-010092-uftc8inx 12926 14 better better RB cord-010092-uftc8inx 12926 15 understand understand VB cord-010092-uftc8inx 12926 16 the the DT cord-010092-uftc8inx 12926 17 precise precise JJ cord-010092-uftc8inx 12926 18 mechanism mechanism NN cord-010092-uftc8inx 12926 19 , , , cord-010092-uftc8inx 12926 20 characterization characterization NN cord-010092-uftc8inx 12926 21 of of IN cord-010092-uftc8inx 12926 22 the the DT cord-010092-uftc8inx 12926 23 potential potential JJ cord-010092-uftc8inx 12926 24 mediators mediator NNS cord-010092-uftc8inx 12926 25 in in IN cord-010092-uftc8inx 12926 26 sheep sheep NN cord-010092-uftc8inx 12926 27 PRBC PRBC NNP cord-010092-uftc8inx 12926 28 is be VBZ cord-010092-uftc8inx 12926 29 required require VBN cord-010092-uftc8inx 12926 30 . . . cord-010092-uftc8inx 12927 1 Aims aim VBZ cord-010092-uftc8inx 12927 2 : : : cord-010092-uftc8inx 12928 1 To to TO cord-010092-uftc8inx 12928 2 characterize characterize VB cord-010092-uftc8inx 12928 3 immunomodulatory immunomodulatory JJ cord-010092-uftc8inx 12928 4 mediators mediator NNS cord-010092-uftc8inx 12928 5 in in IN cord-010092-uftc8inx 12928 6 sheep sheep NN cord-010092-uftc8inx 12928 7 PRBC PRBC NNP cord-010092-uftc8inx 12928 8 supernatants supernatant NNS cord-010092-uftc8inx 12928 9 and and CC cord-010092-uftc8inx 12928 10 to to TO cord-010092-uftc8inx 12928 11 investigate investigate VB cord-010092-uftc8inx 12928 12 whether whether IN cord-010092-uftc8inx 12928 13 storage storage NN cord-010092-uftc8inx 12928 14 duration duration NN cord-010092-uftc8inx 12928 15 impacts impact VBZ cord-010092-uftc8inx 12928 16 the the DT cord-010092-uftc8inx 12928 17 accumulation accumulation NN cord-010092-uftc8inx 12928 18 of of IN cord-010092-uftc8inx 12928 19 these these DT cord-010092-uftc8inx 12928 20 mediators mediator NNS cord-010092-uftc8inx 12928 21 . . . cord-010092-uftc8inx 12929 1 Methods method NNS cord-010092-uftc8inx 12929 2 : : : cord-010092-uftc8inx 12929 3 Sheep Sheep NNS cord-010092-uftc8inx 12929 4 PRBCs prbc NNS cord-010092-uftc8inx 12930 1 ( ( -LRB- cord-010092-uftc8inx 12930 2 n n NN cord-010092-uftc8inx 12930 3 = = SYM cord-010092-uftc8inx 12930 4 5 5 CD cord-010092-uftc8inx 12930 5 ) ) -RRB- cord-010092-uftc8inx 12930 6 , , , cord-010092-uftc8inx 12930 7 prepared prepare VBN cord-010092-uftc8inx 12930 8 according accord VBG cord-010092-uftc8inx 12930 9 to to IN cord-010092-uftc8inx 12930 10 standard standard JJ cord-010092-uftc8inx 12930 11 human human JJ cord-010092-uftc8inx 12930 12 procedures procedure NNS cord-010092-uftc8inx 12930 13 with with IN cord-010092-uftc8inx 12930 14 minor minor JJ cord-010092-uftc8inx 12930 15 modifications modification NNS cord-010092-uftc8inx 12930 16 , , , cord-010092-uftc8inx 12930 17 were be VBD cord-010092-uftc8inx 12930 18 stored store VBN cord-010092-uftc8inx 12930 19 ( ( -LRB- cord-010092-uftc8inx 12930 20 2 2 CD cord-010092-uftc8inx 12930 21 - - SYM cord-010092-uftc8inx 12930 22 6 6 CD cord-010092-uftc8inx 12930 23 ° ° NN cord-010092-uftc8inx 12930 24 C c NN cord-010092-uftc8inx 12930 25 , , , cord-010092-uftc8inx 12930 26 42 42 CD cord-010092-uftc8inx 12930 27 days day NNS cord-010092-uftc8inx 12930 28 ( ( -LRB- cord-010092-uftc8inx 12930 29 D D NNP cord-010092-uftc8inx 12930 30 ) ) -RRB- cord-010092-uftc8inx 12930 31 ) ) -RRB- cord-010092-uftc8inx 12930 32 and and CC cord-010092-uftc8inx 12930 33 sampled sample VBN cord-010092-uftc8inx 12930 34 at at IN cord-010092-uftc8inx 12930 35 D2 D2 NNP cord-010092-uftc8inx 12930 36 and and CC cord-010092-uftc8inx 12930 37 D42 D42 NNP cord-010092-uftc8inx 12930 38 . . . cord-010092-uftc8inx 12931 1 Supernatant Supernatant NNP cord-010092-uftc8inx 12931 2 was be VBD cord-010092-uftc8inx 12931 3 prepared prepare VBN cord-010092-uftc8inx 12931 4 by by IN cord-010092-uftc8inx 12931 5 double double JJ cord-010092-uftc8inx 12931 6 centrifugation centrifugation NN cord-010092-uftc8inx 12931 7 and and CC cord-010092-uftc8inx 12931 8 stored store VBN cord-010092-uftc8inx 12931 9 at at IN cord-010092-uftc8inx 12931 10 À80 À80 NNP cord-010092-uftc8inx 12931 11 ° ° NN cord-010092-uftc8inx 12931 12 C C NNP cord-010092-uftc8inx 12931 13 . . . cord-010092-uftc8inx 12932 1 Concentrations concentration NNS cord-010092-uftc8inx 12932 2 of of IN cord-010092-uftc8inx 12932 3 pro pro JJ cord-010092-uftc8inx 12932 4 - - JJ cord-010092-uftc8inx 12932 5 inflammatory inflammatory JJ cord-010092-uftc8inx 12932 6 cytokines cytokine NNS cord-010092-uftc8inx 12932 7 ( ( -LRB- cord-010092-uftc8inx 12932 8 interleukin interleukin FW cord-010092-uftc8inx 12932 9 ( ( -LRB- cord-010092-uftc8inx 12932 10 IL)-6 IL)-6 NNP cord-010092-uftc8inx 12932 11 , , , cord-010092-uftc8inx 12932 12 IL-1b IL-1b NNP cord-010092-uftc8inx 12932 13 , , , cord-010092-uftc8inx 12932 14 IL-17A IL-17A NNP cord-010092-uftc8inx 12932 15 ) ) -RRB- cord-010092-uftc8inx 12932 16 , , , cord-010092-uftc8inx 12932 17 antiinflammatory antiinflammatory JJ cord-010092-uftc8inx 12932 18 cytokine cytokine NN cord-010092-uftc8inx 12932 19 IL-10 IL-10 NNP cord-010092-uftc8inx 12932 20 and and CC cord-010092-uftc8inx 12932 21 chemokines chemokine NNS cord-010092-uftc8inx 12932 22 ( ( -LRB- cord-010092-uftc8inx 12932 23 IL-8 IL-8 NNP cord-010092-uftc8inx 12932 24 , , , cord-010092-uftc8inx 12932 25 monokine monokine NN cord-010092-uftc8inx 12932 26 induced induce VBN cord-010092-uftc8inx 12932 27 by by IN cord-010092-uftc8inx 12932 28 gamma gamma NN cord-010092-uftc8inx 12932 29 interferon interferon NN cord-010092-uftc8inx 12932 30 ( ( -LRB- cord-010092-uftc8inx 12932 31 MIG MIG NNP cord-010092-uftc8inx 12932 32 ) ) -RRB- cord-010092-uftc8inx 12932 33 and and CC cord-010092-uftc8inx 12932 34 interferon interferon NN cord-010092-uftc8inx 12932 35 - - HYPH cord-010092-uftc8inx 12932 36 gamma gamma NN cord-010092-uftc8inx 12932 37 induced induce VBN cord-010092-uftc8inx 12932 38 protein protein NN cord-010092-uftc8inx 12932 39 ( ( -LRB- cord-010092-uftc8inx 12932 40 IP)-10 IP)-10 NNP cord-010092-uftc8inx 12932 41 ) ) -RRB- cord-010092-uftc8inx 12932 42 were be VBD cord-010092-uftc8inx 12932 43 measured measure VBN cord-010092-uftc8inx 12932 44 using use VBG cord-010092-uftc8inx 12932 45 sheep sheep NN cord-010092-uftc8inx 12932 46 specific specific JJ cord-010092-uftc8inx 12932 47 in in IN cord-010092-uftc8inx 12932 48 - - HYPH cord-010092-uftc8inx 12932 49 house house NN cord-010092-uftc8inx 12932 50 and and CC cord-010092-uftc8inx 12932 51 commercial commercial JJ cord-010092-uftc8inx 12932 52 enzyme enzyme NN cord-010092-uftc8inx 12932 53 linked link VBN cord-010092-uftc8inx 12932 54 immunoassays immunoassays NNP cord-010092-uftc8inx 12932 55 ( ( -LRB- cord-010092-uftc8inx 12932 56 ELISA ELISA NNP cord-010092-uftc8inx 12932 57 ) ) -RRB- cord-010092-uftc8inx 12932 58 . . . cord-010092-uftc8inx 12933 1 Levels level NNS cord-010092-uftc8inx 12933 2 of of IN cord-010092-uftc8inx 12933 3 potential potential JJ cord-010092-uftc8inx 12933 4 non non JJ cord-010092-uftc8inx 12933 5 - - JJ cord-010092-uftc8inx 12933 6 polar polar JJ cord-010092-uftc8inx 12933 7 lipid lipid NN cord-010092-uftc8inx 12933 8 mediators mediator NNS cord-010092-uftc8inx 12933 9 ( ( -LRB- cord-010092-uftc8inx 12933 10 arachidonic arachidonic JJ cord-010092-uftc8inx 12933 11 acid acid NN cord-010092-uftc8inx 12933 12 ( ( -LRB- cord-010092-uftc8inx 12933 13 AA AA NNP cord-010092-uftc8inx 12933 14 ) ) -RRB- cord-010092-uftc8inx 12933 15 , , , cord-010092-uftc8inx 12933 16 12-hydroxyeicosatetraenoic 12-hydroxyeicosatetraenoic CD cord-010092-uftc8inx 12933 17 acid acid NN cord-010092-uftc8inx 12933 18 ( ( -LRB- cord-010092-uftc8inx 12933 19 HETE HETE NNP cord-010092-uftc8inx 12933 20 ) ) -RRB- cord-010092-uftc8inx 12933 21 and and CC cord-010092-uftc8inx 12933 22 15-HETE 15-hete CD cord-010092-uftc8inx 12933 23 ) ) -RRB- cord-010092-uftc8inx 12933 24 were be VBD cord-010092-uftc8inx 12933 25 assessed assess VBN cord-010092-uftc8inx 12933 26 in in IN cord-010092-uftc8inx 12933 27 the the DT cord-010092-uftc8inx 12933 28 sheep sheep NN cord-010092-uftc8inx 12933 29 PRBC PRBC NNP cord-010092-uftc8inx 12933 30 supernatant supernatant VBD cord-010092-uftc8inx 12933 31 using use VBG cord-010092-uftc8inx 12933 32 commercial commercial JJ cord-010092-uftc8inx 12933 33 ELISA ELISA NNP cord-010092-uftc8inx 12933 34 . . . cord-010092-uftc8inx 12934 1 Paired paired JJ cord-010092-uftc8inx 12934 2 t t NN cord-010092-uftc8inx 12934 3 - - HYPH cord-010092-uftc8inx 12934 4 test test NN cord-010092-uftc8inx 12934 5 was be VBD cord-010092-uftc8inx 12934 6 used use VBN cord-010092-uftc8inx 12934 7 to to TO cord-010092-uftc8inx 12934 8 compare compare VB cord-010092-uftc8inx 12934 9 fresh fresh JJ cord-010092-uftc8inx 12934 10 and and CC cord-010092-uftc8inx 12934 11 stored store VBN cord-010092-uftc8inx 12934 12 PRBC PRBC NNP cord-010092-uftc8inx 12934 13 supernatant supernatant JJ cord-010092-uftc8inx 12934 14 ( ( -LRB- cord-010092-uftc8inx 12934 15 P p NN cord-010092-uftc8inx 12934 16 < < XX cord-010092-uftc8inx 12934 17 0.05 0.05 CD cord-010092-uftc8inx 12934 18 ) ) -RRB- cord-010092-uftc8inx 12934 19 . . . cord-010092-uftc8inx 12935 1 Results result NNS cord-010092-uftc8inx 12935 2 are be VBP cord-010092-uftc8inx 12935 3 mean mean JJ cord-010092-uftc8inx 12935 4 AE AE NNP cord-010092-uftc8inx 12935 5 standard standard JJ cord-010092-uftc8inx 12935 6 deviation deviation NN cord-010092-uftc8inx 12935 7 . . . cord-010092-uftc8inx 12936 1 Results result NNS cord-010092-uftc8inx 12936 2 : : : cord-010092-uftc8inx 12937 1 At at IN cord-010092-uftc8inx 12937 2 day day NN cord-010092-uftc8inx 12937 3 2 2 CD cord-010092-uftc8inx 12937 4 , , , cord-010092-uftc8inx 12937 5 AA AA NNP cord-010092-uftc8inx 12937 6 ( ( -LRB- cord-010092-uftc8inx 12937 7 75,142 75,142 CD cord-010092-uftc8inx 12937 8 AE AE NNP cord-010092-uftc8inx 12937 9 47,205 47,205 CD cord-010092-uftc8inx 12937 10 pg pg NN cord-010092-uftc8inx 12937 11 / / SYM cord-010092-uftc8inx 12937 12 mL mL NNP cord-010092-uftc8inx 12937 13 ) ) -RRB- cord-010092-uftc8inx 12937 14 , , , cord-010092-uftc8inx 12937 15 12-HETE 12-hete CD cord-010092-uftc8inx 12937 16 ( ( -LRB- cord-010092-uftc8inx 12937 17 849.1 849.1 CD cord-010092-uftc8inx 12937 18 AE AE NNP cord-010092-uftc8inx 12937 19 235.6 235.6 CD cord-010092-uftc8inx 12937 20 pg pg NN cord-010092-uftc8inx 12937 21 / / SYM cord-010092-uftc8inx 12937 22 mL mL NNP cord-010092-uftc8inx 12937 23 ) ) -RRB- cord-010092-uftc8inx 12937 24 , , , cord-010092-uftc8inx 12937 25 15-HETE 15-hete CD cord-010092-uftc8inx 12937 26 ( ( -LRB- cord-010092-uftc8inx 12937 27 87.6 87.6 CD cord-010092-uftc8inx 12937 28 AE AE NNP cord-010092-uftc8inx 12937 29 32.7 32.7 CD cord-010092-uftc8inx 12937 30 pg pg NNP cord-010092-uftc8inx 12937 31 / / SYM cord-010092-uftc8inx 12937 32 mL mL NNP cord-010092-uftc8inx 12937 33 ) ) -RRB- cord-010092-uftc8inx 12937 34 and and CC cord-010092-uftc8inx 12937 35 IL-1b IL-1b NNP cord-010092-uftc8inx 12937 36 ( ( -LRB- cord-010092-uftc8inx 12937 37 144.7 144.7 CD cord-010092-uftc8inx 12937 38 AE AE NNP cord-010092-uftc8inx 12937 39 198.9 198.9 CD cord-010092-uftc8inx 12937 40 pg pg NN cord-010092-uftc8inx 12937 41 / / SYM cord-010092-uftc8inx 12937 42 mL mL NNP cord-010092-uftc8inx 12937 43 ) ) -RRB- cord-010092-uftc8inx 12937 44 were be VBD cord-010092-uftc8inx 12937 45 detectable detectable JJ cord-010092-uftc8inx 12937 46 in in IN cord-010092-uftc8inx 12937 47 sheep sheep NN cord-010092-uftc8inx 12937 48 PRBCs prbc NNS cord-010092-uftc8inx 12937 49 supernatant supernatant JJ cord-010092-uftc8inx 12937 50 . . . cord-010092-uftc8inx 12938 1 At at IN cord-010092-uftc8inx 12938 2 day day NN cord-010092-uftc8inx 12938 3 42 42 CD cord-010092-uftc8inx 12938 4 , , , cord-010092-uftc8inx 12938 5 storage storage NN cord-010092-uftc8inx 12938 6 duration duration NN cord-010092-uftc8inx 12938 7 significantly significantly RB cord-010092-uftc8inx 12938 8 increased increase VBD cord-010092-uftc8inx 12938 9 concentrations concentration NNS cord-010092-uftc8inx 12938 10 of of IN cord-010092-uftc8inx 12938 11 AA AA NNP cord-010092-uftc8inx 12938 12 ( ( -LRB- cord-010092-uftc8inx 12938 13 136,254 136,254 CD cord-010092-uftc8inx 12938 14 AE AE NNP cord-010092-uftc8inx 12938 15 60,433 60,433 CD cord-010092-uftc8inx 12938 16 pg pg NN cord-010092-uftc8inx 12938 17 / / SYM cord-010092-uftc8inx 12938 18 mL mL NNP cord-010092-uftc8inx 12938 19 , , , cord-010092-uftc8inx 12938 20 P p NN cord-010092-uftc8inx 12938 21 = = SYM cord-010092-uftc8inx 12938 22 0.0425 0.0425 CD cord-010092-uftc8inx 12938 23 ) ) -RRB- cord-010092-uftc8inx 12938 24 and and CC cord-010092-uftc8inx 12938 25 15-HETE 15-hete CD cord-010092-uftc8inx 12938 26 ( ( -LRB- cord-010092-uftc8inx 12938 27 380.9 380.9 CD cord-010092-uftc8inx 12938 28 AE AE NNP cord-010092-uftc8inx 12938 29 116.3 116.3 CD cord-010092-uftc8inx 12938 30 pg pg NN cord-010092-uftc8inx 12938 31 / / SYM cord-010092-uftc8inx 12938 32 mL mL NNP cord-010092-uftc8inx 12938 33 , , , cord-010092-uftc8inx 12938 34 P p NN cord-010092-uftc8inx 12938 35 = = SYM cord-010092-uftc8inx 12938 36 0.0022 0.0022 CD cord-010092-uftc8inx 12938 37 ) ) -RRB- cord-010092-uftc8inx 12938 38 in in IN cord-010092-uftc8inx 12938 39 sheep sheep NN cord-010092-uftc8inx 12938 40 PRBCs prbc NNS cord-010092-uftc8inx 12938 41 supernatant supernatant JJ cord-010092-uftc8inx 12938 42 . . . cord-010092-uftc8inx 12939 1 Summary Summary NNP cord-010092-uftc8inx 12939 2 / / SYM cord-010092-uftc8inx 12939 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 12939 4 : : : cord-010092-uftc8inx 12940 1 Similar similar JJ cord-010092-uftc8inx 12940 2 to to IN cord-010092-uftc8inx 12940 3 reported report VBN cord-010092-uftc8inx 12940 4 findings finding NNS cord-010092-uftc8inx 12940 5 of of IN cord-010092-uftc8inx 12940 6 human human JJ cord-010092-uftc8inx 12940 7 PRBCs prbc NNS cord-010092-uftc8inx 12940 8 , , , cord-010092-uftc8inx 12940 9 the the DT cord-010092-uftc8inx 12940 10 predominant predominant JJ cord-010092-uftc8inx 12940 11 type type NN cord-010092-uftc8inx 12940 12 of of IN cord-010092-uftc8inx 12940 13 immunomodulatory immunomodulatory JJ cord-010092-uftc8inx 12940 14 mediators mediator NNS cord-010092-uftc8inx 12940 15 present present JJ cord-010092-uftc8inx 12940 16 in in IN cord-010092-uftc8inx 12940 17 sheep sheep NN cord-010092-uftc8inx 12940 18 PRBCs prbc NNS cord-010092-uftc8inx 12940 19 were be VBD cord-010092-uftc8inx 12940 20 non non JJ cord-010092-uftc8inx 12940 21 - - JJ cord-010092-uftc8inx 12940 22 polar polar JJ cord-010092-uftc8inx 12940 23 lipids lipid NNS cord-010092-uftc8inx 12940 24 . . . cord-010092-uftc8inx 12941 1 The the DT cord-010092-uftc8inx 12941 2 concentration concentration NN cord-010092-uftc8inx 12941 3 of of IN cord-010092-uftc8inx 12941 4 these these DT cord-010092-uftc8inx 12941 5 non non JJ cord-010092-uftc8inx 12941 6 - - JJ cord-010092-uftc8inx 12941 7 polar polar JJ cord-010092-uftc8inx 12941 8 lipids lipid NNS cord-010092-uftc8inx 12941 9 increased increase VBD cord-010092-uftc8inx 12941 10 during during IN cord-010092-uftc8inx 12941 11 storage storage NN cord-010092-uftc8inx 12941 12 . . . cord-010092-uftc8inx 12942 1 These these DT cord-010092-uftc8inx 12942 2 immunomodulatory immunomodulatory JJ cord-010092-uftc8inx 12942 3 mediators mediator NNS cord-010092-uftc8inx 12942 4 may may MD cord-010092-uftc8inx 12942 5 contribute contribute VB cord-010092-uftc8inx 12942 6 greatly greatly RB cord-010092-uftc8inx 12942 7 to to IN cord-010092-uftc8inx 12942 8 adverse adverse JJ cord-010092-uftc8inx 12942 9 outcomes outcome NNS cord-010092-uftc8inx 12942 10 associated associate VBN cord-010092-uftc8inx 12942 11 with with IN cord-010092-uftc8inx 12942 12 PRBC PRBC NNP cord-010092-uftc8inx 12942 13 transfusions transfusion NNS cord-010092-uftc8inx 12942 14 . . . cord-010092-uftc8inx 12943 1 Further further JJ cord-010092-uftc8inx 12943 2 investigation investigation NN cord-010092-uftc8inx 12943 3 is be VBZ cord-010092-uftc8inx 12943 4 required require VBN cord-010092-uftc8inx 12943 5 to to TO cord-010092-uftc8inx 12943 6 determine determine VB cord-010092-uftc8inx 12943 7 whether whether IN cord-010092-uftc8inx 12943 8 stored store VBN cord-010092-uftc8inx 12943 9 sheep sheep NN cord-010092-uftc8inx 12943 10 PRBCs prbc NNS cord-010092-uftc8inx 12943 11 supernatant supernatant JJ cord-010092-uftc8inx 12943 12 induce induce VBP cord-010092-uftc8inx 12943 13 immunomodulation immunomodulation NN cord-010092-uftc8inx 12943 14 in in IN cord-010092-uftc8inx 12943 15 sheep sheep NN cord-010092-uftc8inx 12943 16 in in IN cord-010092-uftc8inx 12943 17 vitro vitro FW cord-010092-uftc8inx 12943 18 and and CC cord-010092-uftc8inx 12943 19 in in IN cord-010092-uftc8inx 12943 20 vivo vivo NN cord-010092-uftc8inx 12943 21 transfusion transfusion NN cord-010092-uftc8inx 12943 22 models model NNS cord-010092-uftc8inx 12943 23 . . . cord-010092-uftc8inx 12944 1 Background background NN cord-010092-uftc8inx 12944 2 : : : cord-010092-uftc8inx 12945 1 DSHTR DSHTR NNP cord-010092-uftc8inx 12945 2 incidence incidence NN cord-010092-uftc8inx 12945 3 is be VBZ cord-010092-uftc8inx 12945 4 reported report VBN cord-010092-uftc8inx 12945 5 as as IN cord-010092-uftc8inx 12945 6 1 1 CD cord-010092-uftc8inx 12945 7 in in IN cord-010092-uftc8inx 12945 8 2,500 2,500 CD cord-010092-uftc8inx 12945 9 transfusions transfusion NNS cord-010092-uftc8inx 12945 10 , , , cord-010092-uftc8inx 12945 11 presenting present VBG cord-010092-uftc8inx 12945 12 days day NNS cord-010092-uftc8inx 12945 13 to to IN cord-010092-uftc8inx 12945 14 months month NNS cord-010092-uftc8inx 12945 15 after after IN cord-010092-uftc8inx 12945 16 the the DT cord-010092-uftc8inx 12945 17 transfusion transfusion NN cord-010092-uftc8inx 12945 18 . . . cord-010092-uftc8inx 12946 1 The the DT cord-010092-uftc8inx 12946 2 published publish VBN cord-010092-uftc8inx 12946 3 data datum NNS cord-010092-uftc8inx 12946 4 addressing address VBG cord-010092-uftc8inx 12946 5 the the DT cord-010092-uftc8inx 12946 6 correlation correlation NN cord-010092-uftc8inx 12946 7 between between IN cord-010092-uftc8inx 12946 8 the the DT cord-010092-uftc8inx 12946 9 strength strength NN cord-010092-uftc8inx 12946 10 of of IN cord-010092-uftc8inx 12946 11 the the DT cord-010092-uftc8inx 12946 12 antibodies antibody NNS cord-010092-uftc8inx 12946 13 detected detect VBN cord-010092-uftc8inx 12946 14 after after IN cord-010092-uftc8inx 12946 15 a a DT cord-010092-uftc8inx 12946 16 DSHTR DSHTR NNP cord-010092-uftc8inx 12946 17 has have VBZ cord-010092-uftc8inx 12946 18 taken take VBN cord-010092-uftc8inx 12946 19 place place NN cord-010092-uftc8inx 12946 20 and and CC cord-010092-uftc8inx 12946 21 the the DT cord-010092-uftc8inx 12946 22 corresponding correspond VBG cord-010092-uftc8inx 12946 23 clinical clinical JJ cord-010092-uftc8inx 12946 24 symptoms symptom NNS cord-010092-uftc8inx 12946 25 as as IN cord-010092-uftc8inx 12946 26 measured measure VBN cord-010092-uftc8inx 12946 27 by by IN cord-010092-uftc8inx 12946 28 laboratory laboratory NN cord-010092-uftc8inx 12946 29 parameters parameter NNS cord-010092-uftc8inx 12946 30 that that WDT cord-010092-uftc8inx 12946 31 assess assess VBP cord-010092-uftc8inx 12946 32 the the DT cord-010092-uftc8inx 12946 33 presence presence NN cord-010092-uftc8inx 12946 34 of of IN cord-010092-uftc8inx 12946 35 hemolysis hemolysis NN cord-010092-uftc8inx 12946 36 is be VBZ cord-010092-uftc8inx 12946 37 limited limit VBN cord-010092-uftc8inx 12946 38 . . . cord-010092-uftc8inx 12947 1 Aims aim VBZ cord-010092-uftc8inx 12947 2 : : : cord-010092-uftc8inx 12948 1 The the DT cord-010092-uftc8inx 12948 2 aim aim NN cord-010092-uftc8inx 12948 3 of of IN cord-010092-uftc8inx 12948 4 this this DT cord-010092-uftc8inx 12948 5 study study NN cord-010092-uftc8inx 12948 6 is be VBZ cord-010092-uftc8inx 12948 7 to to TO cord-010092-uftc8inx 12948 8 evaluate evaluate VB cord-010092-uftc8inx 12948 9 the the DT cord-010092-uftc8inx 12948 10 correlation correlation NN cord-010092-uftc8inx 12948 11 between between IN cord-010092-uftc8inx 12948 12 the the DT cord-010092-uftc8inx 12948 13 results result NNS cord-010092-uftc8inx 12948 14 of of IN cord-010092-uftc8inx 12948 15 the the DT cord-010092-uftc8inx 12948 16 DAT DAT NNP cord-010092-uftc8inx 12948 17 , , , cord-010092-uftc8inx 12948 18 automated automate VBN cord-010092-uftc8inx 12948 19 and and CC cord-010092-uftc8inx 12948 20 manual manual JJ cord-010092-uftc8inx 12948 21 antibody antibody NN cord-010092-uftc8inx 12948 22 reactivity reactivity NN cord-010092-uftc8inx 12948 23 strength strength NN cord-010092-uftc8inx 12948 24 with with IN cord-010092-uftc8inx 12948 25 the the DT cord-010092-uftc8inx 12948 26 corresponding correspond VBG cord-010092-uftc8inx 12948 27 clinical clinical JJ cord-010092-uftc8inx 12948 28 parameters parameter NNS cord-010092-uftc8inx 12948 29 of of IN cord-010092-uftc8inx 12948 30 Hemoglobin hemoglobin NN cord-010092-uftc8inx 12948 31 , , , cord-010092-uftc8inx 12948 32 Lactate Lactate NNP cord-010092-uftc8inx 12948 33 Dehydrogenase Dehydrogenase NNP cord-010092-uftc8inx 12948 34 ( ( -LRB- cord-010092-uftc8inx 12948 35 LDH LDH NNP cord-010092-uftc8inx 12948 36 ) ) -RRB- cord-010092-uftc8inx 12948 37 , , , cord-010092-uftc8inx 12948 38 Bilirubin bilirubin NN cord-010092-uftc8inx 12948 39 , , , cord-010092-uftc8inx 12948 40 and and CC cord-010092-uftc8inx 12948 41 Haptoglobin Haptoglobin NNP cord-010092-uftc8inx 12948 42 . . . cord-010092-uftc8inx 12949 1 Methods method NNS cord-010092-uftc8inx 12949 2 : : : cord-010092-uftc8inx 12950 1 A a DT cord-010092-uftc8inx 12950 2 DSHTR DSHTR NNP cord-010092-uftc8inx 12950 3 is be VBZ cord-010092-uftc8inx 12950 4 defined define VBN cord-010092-uftc8inx 12950 5 as as IN cord-010092-uftc8inx 12950 6 discovering discover VBG cord-010092-uftc8inx 12950 7 a a DT cord-010092-uftc8inx 12950 8 new new JJ cord-010092-uftc8inx 12950 9 antibody antibody NN cord-010092-uftc8inx 12950 10 within within IN cord-010092-uftc8inx 12950 11 28 28 CD cord-010092-uftc8inx 12950 12 days day NNS cord-010092-uftc8inx 12950 13 of of IN cord-010092-uftc8inx 12950 14 a a DT cord-010092-uftc8inx 12950 15 transfusion transfusion NN cord-010092-uftc8inx 12950 16 . . . cord-010092-uftc8inx 12951 1 For for IN cord-010092-uftc8inx 12951 2 all all DT cord-010092-uftc8inx 12951 3 positive positive JJ cord-010092-uftc8inx 12951 4 antibody antibody NN cord-010092-uftc8inx 12951 5 screens screen NNS cord-010092-uftc8inx 12951 6 , , , cord-010092-uftc8inx 12951 7 a a DT cord-010092-uftc8inx 12951 8 work work NN cord-010092-uftc8inx 12951 9 - - HYPH cord-010092-uftc8inx 12951 10 up up NN cord-010092-uftc8inx 12951 11 is be VBZ cord-010092-uftc8inx 12951 12 initiated initiate VBN cord-010092-uftc8inx 12951 13 consisting consist VBG cord-010092-uftc8inx 12951 14 of of IN cord-010092-uftc8inx 12951 15 identification identification NN cord-010092-uftc8inx 12951 16 panels panel NNS cord-010092-uftc8inx 12951 17 , , , cord-010092-uftc8inx 12951 18 DATs DATs NNPS cord-010092-uftc8inx 12951 19 , , , cord-010092-uftc8inx 12951 20 antigen antigen NN cord-010092-uftc8inx 12951 21 typing typing NN cord-010092-uftc8inx 12951 22 of of IN cord-010092-uftc8inx 12951 23 the the DT cord-010092-uftc8inx 12951 24 red red JJ cord-010092-uftc8inx 12951 25 cells cell NNS cord-010092-uftc8inx 12951 26 transfused transfuse VBN cord-010092-uftc8inx 12951 27 , , , cord-010092-uftc8inx 12951 28 and and CC cord-010092-uftc8inx 12951 29 eluates eluate NNS cord-010092-uftc8inx 12951 30 at at IN cord-010092-uftc8inx 12951 31 the the DT cord-010092-uftc8inx 12951 32 discretion discretion NN cord-010092-uftc8inx 12951 33 of of IN cord-010092-uftc8inx 12951 34 the the DT cord-010092-uftc8inx 12951 35 Transfusion Transfusion NNP cord-010092-uftc8inx 12951 36 Medicine Medicine NNP cord-010092-uftc8inx 12951 37 Physician Physician NNP cord-010092-uftc8inx 12951 38 . . . cord-010092-uftc8inx 12952 1 Additional additional JJ cord-010092-uftc8inx 12952 2 laboratory laboratory NN cord-010092-uftc8inx 12952 3 testing testing NN cord-010092-uftc8inx 12952 4 for for IN cord-010092-uftc8inx 12952 5 hemolysis hemolysis NN cord-010092-uftc8inx 12952 6 is be VBZ cord-010092-uftc8inx 12952 7 requested request VBN cord-010092-uftc8inx 12952 8 when when WRB cord-010092-uftc8inx 12952 9 indicated indicate VBN cord-010092-uftc8inx 12952 10 . . . cord-010092-uftc8inx 12953 1 A a DT cord-010092-uftc8inx 12953 2 retrospective retrospective JJ cord-010092-uftc8inx 12953 3 review review NN cord-010092-uftc8inx 12953 4 was be VBD cord-010092-uftc8inx 12953 5 conducted conduct VBN cord-010092-uftc8inx 12953 6 of of IN cord-010092-uftc8inx 12953 7 patients patient NNS cord-010092-uftc8inx 12953 8 who who WP cord-010092-uftc8inx 12953 9 were be VBD cord-010092-uftc8inx 12953 10 identified identify VBN cord-010092-uftc8inx 12953 11 as as IN cord-010092-uftc8inx 12953 12 having have VBG cord-010092-uftc8inx 12953 13 a a DT cord-010092-uftc8inx 12953 14 DSHTR DSHTR NNP cord-010092-uftc8inx 12953 15 . . . cord-010092-uftc8inx 12954 1 Levels level NNS cord-010092-uftc8inx 12954 2 of of IN cord-010092-uftc8inx 12954 3 Hemoglobin Hemoglobin NNP cord-010092-uftc8inx 12954 4 , , , cord-010092-uftc8inx 12954 5 LDH LDH NNP cord-010092-uftc8inx 12954 6 , , , cord-010092-uftc8inx 12954 7 and and CC cord-010092-uftc8inx 12954 8 transfusion transfusion NN cord-010092-uftc8inx 12954 9 safety safety NN cord-010092-uftc8inx 12954 10 Background background NN cord-010092-uftc8inx 12954 11 : : : cord-010092-uftc8inx 12955 1 RhD RhD NNP cord-010092-uftc8inx 12955 2 immunoglobulin immunoglobulin NNP cord-010092-uftc8inx 12955 3 ( ( -LRB- cord-010092-uftc8inx 12955 4 RhDIg RhDIg NNP cord-010092-uftc8inx 12955 5 ) ) -RRB- cord-010092-uftc8inx 12955 6 has have VBZ cord-010092-uftc8inx 12955 7 been be VBN cord-010092-uftc8inx 12955 8 available available JJ cord-010092-uftc8inx 12955 9 for for IN cord-010092-uftc8inx 12955 10 50 50 CD cord-010092-uftc8inx 12955 11 years year NNS cord-010092-uftc8inx 12955 12 in in IN cord-010092-uftc8inx 12955 13 Australia Australia NNP cord-010092-uftc8inx 12955 14 . . . cord-010092-uftc8inx 12956 1 Since since IN cord-010092-uftc8inx 12956 2 its -PRON- PRP$ cord-010092-uftc8inx 12956 3 introduction introduction NN cord-010092-uftc8inx 12956 4 for for IN cord-010092-uftc8inx 12956 5 routine routine JJ cord-010092-uftc8inx 12956 6 antenatal antenatal JJ cord-010092-uftc8inx 12956 7 and and CC cord-010092-uftc8inx 12956 8 postpartum postpartum NN cord-010092-uftc8inx 12956 9 prophylaxis prophylaxis NN cord-010092-uftc8inx 12956 10 , , , cord-010092-uftc8inx 12956 11 alloimmunisation alloimmunisation NN cord-010092-uftc8inx 12956 12 has have VBZ cord-010092-uftc8inx 12956 13 decreased decrease VBN cord-010092-uftc8inx 12956 14 from from IN cord-010092-uftc8inx 12956 15 16 16 CD cord-010092-uftc8inx 12956 16 % % NN cord-010092-uftc8inx 12956 17 to to TO cord-010092-uftc8inx 12956 18 0.2 0.2 CD cord-010092-uftc8inx 12956 19 % % NN cord-010092-uftc8inx 12956 20 , , , cord-010092-uftc8inx 12956 21 reducing reduce VBG cord-010092-uftc8inx 12956 22 the the DT cord-010092-uftc8inx 12956 23 number number NN cord-010092-uftc8inx 12956 24 of of IN cord-010092-uftc8inx 12956 25 Australian australian JJ cord-010092-uftc8inx 12956 26 deaths death NNS cord-010092-uftc8inx 12956 27 from from IN cord-010092-uftc8inx 12956 28 haemolytic haemolytic JJ cord-010092-uftc8inx 12956 29 disease disease NN cord-010092-uftc8inx 12956 30 of of IN cord-010092-uftc8inx 12956 31 the the DT cord-010092-uftc8inx 12956 32 newborn newborn NN cord-010092-uftc8inx 12956 33 over over IN cord-010092-uftc8inx 12956 34 a a DT cord-010092-uftc8inx 12956 35 hundred hundred CD cord-010092-uftc8inx 12956 36 - - RB cord-010092-uftc8inx 12956 37 fold fold RB cord-010092-uftc8inx 12956 38 , , , cord-010092-uftc8inx 12956 39 to to IN cord-010092-uftc8inx 12956 40 approximately approximately RB cord-010092-uftc8inx 12956 41 0.01 0.01 CD cord-010092-uftc8inx 12956 42 deaths death NNS cord-010092-uftc8inx 12956 43 per per IN cord-010092-uftc8inx 12956 44 1000 1000 CD cord-010092-uftc8inx 12956 45 . . . cord-010092-uftc8inx 12957 1 Blood blood NN cord-010092-uftc8inx 12957 2 Matters matter NNS cord-010092-uftc8inx 12958 1 Serious serious JJ cord-010092-uftc8inx 12958 2 Transfusion Transfusion NNP cord-010092-uftc8inx 12958 3 Incident Incident NNP cord-010092-uftc8inx 12958 4 Reporting Reporting NNP cord-010092-uftc8inx 12958 5 ( ( -LRB- cord-010092-uftc8inx 12958 6 STIR stir NN cord-010092-uftc8inx 12958 7 ) ) -RRB- cord-010092-uftc8inx 12958 8 system system NN cord-010092-uftc8inx 12958 9 has have VBZ cord-010092-uftc8inx 12958 10 been be VBN cord-010092-uftc8inx 12958 11 collecting collect VBG cord-010092-uftc8inx 12958 12 transfusion transfusion NN cord-010092-uftc8inx 12958 13 incidents incident NNS cord-010092-uftc8inx 12958 14 and and CC cord-010092-uftc8inx 12958 15 adverse adverse JJ cord-010092-uftc8inx 12958 16 events event NNS cord-010092-uftc8inx 12958 17 across across IN cord-010092-uftc8inx 12958 18 four four CD cord-010092-uftc8inx 12958 19 Australian australian JJ cord-010092-uftc8inx 12958 20 jurisdictions jurisdiction NNS cord-010092-uftc8inx 12958 21 since since IN cord-010092-uftc8inx 12958 22 2007 2007 CD cord-010092-uftc8inx 12958 23 . . . cord-010092-uftc8inx 12959 1 Since since IN cord-010092-uftc8inx 12959 2 January January NNP cord-010092-uftc8inx 12959 3 2015 2015 CD cord-010092-uftc8inx 12959 4 , , , cord-010092-uftc8inx 12959 5 RhDIg RhDIg NNP cord-010092-uftc8inx 12959 6 administration administration NN cord-010092-uftc8inx 12959 7 errors error NNS cord-010092-uftc8inx 12959 8 have have VBP cord-010092-uftc8inx 12959 9 been be VBN cord-010092-uftc8inx 12959 10 reported report VBN cord-010092-uftc8inx 12959 11 . . . cord-010092-uftc8inx 12960 1 Aims aim VBZ cord-010092-uftc8inx 12960 2 : : : cord-010092-uftc8inx 12961 1 To to TO cord-010092-uftc8inx 12961 2 understand understand VB cord-010092-uftc8inx 12961 3 incidents incident NNS cord-010092-uftc8inx 12961 4 relating relate VBG cord-010092-uftc8inx 12961 5 to to IN cord-010092-uftc8inx 12961 6 the the DT cord-010092-uftc8inx 12961 7 administration administration NN cord-010092-uftc8inx 12961 8 of of IN cord-010092-uftc8inx 12961 9 RhDIg RhDIg NNPS cord-010092-uftc8inx 12961 10 and and CC cord-010092-uftc8inx 12961 11 increase increase VB cord-010092-uftc8inx 12961 12 safety safety NN cord-010092-uftc8inx 12961 13 and and CC cord-010092-uftc8inx 12961 14 awareness awareness NN cord-010092-uftc8inx 12961 15 of of IN cord-010092-uftc8inx 12961 16 risks risk NNS cord-010092-uftc8inx 12961 17 . . . cord-010092-uftc8inx 12962 1 Methods method NNS cord-010092-uftc8inx 12962 2 : : : cord-010092-uftc8inx 12963 1 Health health NN cord-010092-uftc8inx 12963 2 services service NNS cord-010092-uftc8inx 12963 3 registered register VBN cord-010092-uftc8inx 12963 4 with with IN cord-010092-uftc8inx 12963 5 STIR STIR NNP cord-010092-uftc8inx 12963 6 ( ( -LRB- cord-010092-uftc8inx 12963 7 n n NN cord-010092-uftc8inx 12963 8 = = SYM cord-010092-uftc8inx 12963 9 93 93 CD cord-010092-uftc8inx 12963 10 ) ) -RRB- cord-010092-uftc8inx 12963 11 were be VBD cord-010092-uftc8inx 12963 12 notified notify VBN cord-010092-uftc8inx 12963 13 of of IN cord-010092-uftc8inx 12963 14 the the DT cord-010092-uftc8inx 12963 15 inclusion inclusion NN cord-010092-uftc8inx 12963 16 of of IN cord-010092-uftc8inx 12963 17 reporting report VBG cord-010092-uftc8inx 12963 18 RhDIg RhDIg NNS cord-010092-uftc8inx 12963 19 incidents incident NNS cord-010092-uftc8inx 12963 20 . . . cord-010092-uftc8inx 12964 1 When when WRB cord-010092-uftc8inx 12964 2 an an DT cord-010092-uftc8inx 12964 3 incident incident NN cord-010092-uftc8inx 12964 4 is be VBZ cord-010092-uftc8inx 12964 5 identified identify VBN cord-010092-uftc8inx 12964 6 , , , cord-010092-uftc8inx 12964 7 the the DT cord-010092-uftc8inx 12964 8 reporter reporter NN cord-010092-uftc8inx 12964 9 sends send VBZ cord-010092-uftc8inx 12964 10 an an DT cord-010092-uftc8inx 12964 11 online online JJ cord-010092-uftc8inx 12964 12 notification notification NN cord-010092-uftc8inx 12964 13 to to TO cord-010092-uftc8inx 12964 14 STIR stir VB cord-010092-uftc8inx 12964 15 , , , cord-010092-uftc8inx 12964 16 prompting prompt VBG cord-010092-uftc8inx 12964 17 the the DT cord-010092-uftc8inx 12964 18 appropriate appropriate JJ cord-010092-uftc8inx 12964 19 investigation investigation NN cord-010092-uftc8inx 12964 20 form form NN cord-010092-uftc8inx 12964 21 to to TO cord-010092-uftc8inx 12964 22 be be VB cord-010092-uftc8inx 12964 23 sent send VBN cord-010092-uftc8inx 12964 24 for for IN cord-010092-uftc8inx 12964 25 completion completion NN cord-010092-uftc8inx 12964 26 . . . cord-010092-uftc8inx 12965 1 The the DT cord-010092-uftc8inx 12965 2 completed complete VBN cord-010092-uftc8inx 12965 3 incident incident NN cord-010092-uftc8inx 12965 4 data datum NNS cord-010092-uftc8inx 12965 5 are be VBP cord-010092-uftc8inx 12965 6 reviewed review VBN cord-010092-uftc8inx 12965 7 and and CC cord-010092-uftc8inx 12965 8 validated validate VBN cord-010092-uftc8inx 12965 9 by by IN cord-010092-uftc8inx 12965 10 an an DT cord-010092-uftc8inx 12965 11 expert expert NN cord-010092-uftc8inx 12965 12 group group NN cord-010092-uftc8inx 12965 13 . . . cord-010092-uftc8inx 12966 1 Data Data NNP cord-010092-uftc8inx 12966 2 is be VBZ cord-010092-uftc8inx 12966 3 de de NNP cord-010092-uftc8inx 12966 4 - - VBN cord-010092-uftc8inx 12966 5 identified identify VBN cord-010092-uftc8inx 12966 6 and and CC cord-010092-uftc8inx 12966 7 collated collate VBN cord-010092-uftc8inx 12966 8 for for IN cord-010092-uftc8inx 12966 9 reporting reporting NN cord-010092-uftc8inx 12966 10 . . . cord-010092-uftc8inx 12967 1 Results result NNS cord-010092-uftc8inx 12967 2 : : : cord-010092-uftc8inx 12968 1 During during IN cord-010092-uftc8inx 12968 2 the the DT cord-010092-uftc8inx 12968 3 period period NN cord-010092-uftc8inx 12968 4 January January NNP cord-010092-uftc8inx 12968 5 2015-December 2015-december CD cord-010092-uftc8inx 12968 6 2018 2018 CD cord-010092-uftc8inx 12968 7 , , , cord-010092-uftc8inx 12968 8 45 45 CD cord-010092-uftc8inx 12968 9 reports report NNS cord-010092-uftc8inx 12968 10 were be VBD cord-010092-uftc8inx 12968 11 received receive VBN cord-010092-uftc8inx 12968 12 ; ; : cord-010092-uftc8inx 12968 13 43 43 CD cord-010092-uftc8inx 12968 14 reports report NNS cord-010092-uftc8inx 12968 15 were be VBD cord-010092-uftc8inx 12968 16 validated validate VBN cord-010092-uftc8inx 12968 17 , , , cord-010092-uftc8inx 12968 18 with with IN cord-010092-uftc8inx 12968 19 2 2 CD cord-010092-uftc8inx 12968 20 reports report NNS cord-010092-uftc8inx 12968 21 excluded exclude VBN cord-010092-uftc8inx 12968 22 ( ( -LRB- cord-010092-uftc8inx 12968 23 reactions reaction NNS cord-010092-uftc8inx 12968 24 rather rather RB cord-010092-uftc8inx 12968 25 than than IN cord-010092-uftc8inx 12968 26 administration administration NN cord-010092-uftc8inx 12968 27 errors error NNS cord-010092-uftc8inx 12968 28 ) ) -RRB- cord-010092-uftc8inx 12968 29 . . . cord-010092-uftc8inx 12969 1 Reports report NNS cord-010092-uftc8inx 12969 2 were be VBD cord-010092-uftc8inx 12969 3 categorised categorise VBN cord-010092-uftc8inx 12969 4 as as IN cord-010092-uftc8inx 12969 5 below below RB cord-010092-uftc8inx 12969 6 : : : cord-010092-uftc8inx 12970 1 Background background NN cord-010092-uftc8inx 12970 2 : : : cord-010092-uftc8inx 12971 1 Following follow VBG cord-010092-uftc8inx 12971 2 the the DT cord-010092-uftc8inx 12971 3 NICE nice JJ cord-010092-uftc8inx 12971 4 Transfusion Transfusion NNP cord-010092-uftc8inx 12971 5 Guidelines Guidelines NNPS cord-010092-uftc8inx 12971 6 , , , cord-010092-uftc8inx 12971 7 recommending recommend VBG cord-010092-uftc8inx 12971 8 offering offer VBG cord-010092-uftc8inx 12971 9 iron iron NN cord-010092-uftc8inx 12971 10 before before IN cord-010092-uftc8inx 12971 11 and and CC cord-010092-uftc8inx 12971 12 after after IN cord-010092-uftc8inx 12971 13 surgery surgery NN cord-010092-uftc8inx 12971 14 to to IN cord-010092-uftc8inx 12971 15 patients patient NNS cord-010092-uftc8inx 12971 16 with with IN cord-010092-uftc8inx 12971 17 iron iron NN cord-010092-uftc8inx 12971 18 - - HYPH cord-010092-uftc8inx 12971 19 deficiency deficiency NN cord-010092-uftc8inx 12971 20 anaemia anaemia NN cord-010092-uftc8inx 12971 21 ( ( -LRB- cord-010092-uftc8inx 12971 22 IDA IDA NNP cord-010092-uftc8inx 12971 23 ) ) -RRB- cord-010092-uftc8inx 12971 24 , , , cord-010092-uftc8inx 12971 25 we -PRON- PRP cord-010092-uftc8inx 12971 26 worked work VBD cord-010092-uftc8inx 12971 27 collaboratively collaboratively RB cord-010092-uftc8inx 12971 28 with with IN cord-010092-uftc8inx 12971 29 the the DT cord-010092-uftc8inx 12971 30 anaesthetic anaesthetic JJ cord-010092-uftc8inx 12971 31 and and CC cord-010092-uftc8inx 12971 32 pre pre JJ cord-010092-uftc8inx 12971 33 - - JJ cord-010092-uftc8inx 12971 34 operative operative JJ cord-010092-uftc8inx 12971 35 team team NN cord-010092-uftc8inx 12971 36 to to TO cord-010092-uftc8inx 12971 37 implement implement VB cord-010092-uftc8inx 12971 38 a a DT cord-010092-uftc8inx 12971 39 clear clear JJ cord-010092-uftc8inx 12971 40 and and CC cord-010092-uftc8inx 12971 41 robust robust JJ cord-010092-uftc8inx 12971 42 anaemia anaemia NN cord-010092-uftc8inx 12971 43 pathway pathway NN cord-010092-uftc8inx 12971 44 for for IN cord-010092-uftc8inx 12971 45 pre pre JJ cord-010092-uftc8inx 12971 46 - - JJ cord-010092-uftc8inx 12971 47 operative operative JJ cord-010092-uftc8inx 12971 48 haemoglobin haemoglobin NN cord-010092-uftc8inx 12971 49 ( ( -LRB- cord-010092-uftc8inx 12971 50 Hb Hb NNP cord-010092-uftc8inx 12971 51 ) ) -RRB- cord-010092-uftc8inx 12971 52 optimisation optimisation NN cord-010092-uftc8inx 12971 53 . . . cord-010092-uftc8inx 12972 1 Oral oral JJ cord-010092-uftc8inx 12972 2 iron iron NN cord-010092-uftc8inx 12972 3 was be VBD cord-010092-uftc8inx 12972 4 started start VBN cord-010092-uftc8inx 12972 5 , , , cord-010092-uftc8inx 12972 6 where where WRB cord-010092-uftc8inx 12972 7 appropriate appropriate JJ cord-010092-uftc8inx 12972 8 , , , cord-010092-uftc8inx 12972 9 and and CC cord-010092-uftc8inx 12972 10 our -PRON- PRP$ cord-010092-uftc8inx 12972 11 anaemia anaemia NN cord-010092-uftc8inx 12972 12 pro pro JJ cord-010092-uftc8inx 12972 13 - - JJ cord-010092-uftc8inx 12972 14 forma forma JJ cord-010092-uftc8inx 12972 15 was be VBD cord-010092-uftc8inx 12972 16 sent send VBN cord-010092-uftc8inx 12972 17 for for IN cord-010092-uftc8inx 12972 18 review review NN cord-010092-uftc8inx 12972 19 in in IN cord-010092-uftc8inx 12972 20 a a DT cord-010092-uftc8inx 12972 21 virtual virtual JJ cord-010092-uftc8inx 12972 22 clinic clinic NN cord-010092-uftc8inx 12972 23 to to TO cord-010092-uftc8inx 12972 24 assess assess VB cord-010092-uftc8inx 12972 25 eligibility eligibility NN cord-010092-uftc8inx 12972 26 for for IN cord-010092-uftc8inx 12972 27 intravenous intravenous JJ cord-010092-uftc8inx 12972 28 iron iron NN cord-010092-uftc8inx 12972 29 . . . cord-010092-uftc8inx 12973 1 We -PRON- PRP cord-010092-uftc8inx 12973 2 performed perform VBD cord-010092-uftc8inx 12973 3 a a DT cord-010092-uftc8inx 12973 4 retrospective retrospective JJ cord-010092-uftc8inx 12973 5 evaluation evaluation NN cord-010092-uftc8inx 12973 6 of of IN cord-010092-uftc8inx 12973 7 the the DT cord-010092-uftc8inx 12973 8 patients patient NNS cord-010092-uftc8inx 12973 9 who who WP cord-010092-uftc8inx 12973 10 received receive VBD cord-010092-uftc8inx 12973 11 IV IV NNP cord-010092-uftc8inx 12973 12 iron iron NN cord-010092-uftc8inx 12973 13 during during IN cord-010092-uftc8inx 12973 14 the the DT cord-010092-uftc8inx 12973 15 anaemia anaemia NN cord-010092-uftc8inx 12973 16 pathway pathway NN cord-010092-uftc8inx 12973 17 . . . cord-010092-uftc8inx 12974 1 Aims aim VBZ cord-010092-uftc8inx 12974 2 : : : cord-010092-uftc8inx 12975 1 The the DT cord-010092-uftc8inx 12975 2 aim aim NN cord-010092-uftc8inx 12975 3 of of IN cord-010092-uftc8inx 12975 4 this this DT cord-010092-uftc8inx 12975 5 retrospective retrospective JJ cord-010092-uftc8inx 12975 6 evaluation evaluation NN cord-010092-uftc8inx 12975 7 was be VBD cord-010092-uftc8inx 12975 8 to to TO cord-010092-uftc8inx 12975 9 look look VB cord-010092-uftc8inx 12975 10 at at IN cord-010092-uftc8inx 12975 11 the the DT cord-010092-uftc8inx 12975 12 cohort cohort NN cord-010092-uftc8inx 12975 13 of of IN cord-010092-uftc8inx 12975 14 patients patient NNS cord-010092-uftc8inx 12975 15 who who WP cord-010092-uftc8inx 12975 16 had have VBD cord-010092-uftc8inx 12975 17 received receive VBN cord-010092-uftc8inx 12975 18 IV IV NNP cord-010092-uftc8inx 12975 19 iron iron NN cord-010092-uftc8inx 12975 20 in in IN cord-010092-uftc8inx 12975 21 2017 2017 CD cord-010092-uftc8inx 12975 22 and and CC cord-010092-uftc8inx 12975 23 assess assess VB cord-010092-uftc8inx 12975 24 the the DT cord-010092-uftc8inx 12975 25 effect effect NN cord-010092-uftc8inx 12975 26 of of IN cord-010092-uftc8inx 12975 27 IV IV NNP cord-010092-uftc8inx 12975 28 iron iron NN cord-010092-uftc8inx 12975 29 on on IN cord-010092-uftc8inx 12975 30 haemoglobin haemoglobin NN cord-010092-uftc8inx 12975 31 levels level NNS cord-010092-uftc8inx 12975 32 for for IN cord-010092-uftc8inx 12975 33 different different JJ cord-010092-uftc8inx 12975 34 defined define VBN cord-010092-uftc8inx 12975 35 groups group NNS cord-010092-uftc8inx 12975 36 . . . cord-010092-uftc8inx 12976 1 Methods method NNS cord-010092-uftc8inx 12976 2 : : : cord-010092-uftc8inx 12977 1 We -PRON- PRP cord-010092-uftc8inx 12977 2 classified classify VBD cord-010092-uftc8inx 12977 3 patients patient NNS cord-010092-uftc8inx 12977 4 , , , cord-010092-uftc8inx 12977 5 as as IN cord-010092-uftc8inx 12977 6 described describe VBN cord-010092-uftc8inx 12977 7 in in IN cord-010092-uftc8inx 12977 8 Munting Munting NNP cord-010092-uftc8inx 12977 9 and and CC cord-010092-uftc8inx 12977 10 Klein Klein NNP cord-010092-uftc8inx 12977 11 , , , cord-010092-uftc8inx 12977 12 2019 2019 CD cord-010092-uftc8inx 12977 13 , , , cord-010092-uftc8inx 12977 14 depending depend VBG cord-010092-uftc8inx 12977 15 on on IN cord-010092-uftc8inx 12977 16 their -PRON- PRP$ cord-010092-uftc8inx 12977 17 iron iron NN cord-010092-uftc8inx 12977 18 parameters parameter NNS cord-010092-uftc8inx 12977 19 as as IN cord-010092-uftc8inx 12977 20 having have VBG cord-010092-uftc8inx 12977 21 either either CC cord-010092-uftc8inx 12977 22 : : : cord-010092-uftc8inx 12978 1 -IDAserum -IDAserum NNP cord-010092-uftc8inx 12978 2 ferritin ferritin NNP cord-010092-uftc8inx 12979 1 < < XX cord-010092-uftc8inx 12980 1 30 30 CD cord-010092-uftc8inx 12980 2 mg mg NNP cord-010092-uftc8inx 12980 3 / / SYM cord-010092-uftc8inx 12980 4 L l NN cord-010092-uftc8inx 12981 1 -Chronic -Chronic : cord-010092-uftc8inx 12981 2 inflammation inflammation NN cord-010092-uftc8inx 12981 3 with with IN cord-010092-uftc8inx 12981 4 IDAserum IDAserum NNP cord-010092-uftc8inx 12981 5 ferritin ferritin NNP cord-010092-uftc8inx 12981 6 30 30 CD cord-010092-uftc8inx 12981 7 - - SYM cord-010092-uftc8inx 12981 8 100 100 CD cord-010092-uftc8inx 12981 9 mg mg NNP cord-010092-uftc8inx 12981 10 / / SYM cord-010092-uftc8inx 12981 11 L l NN cord-010092-uftc8inx 12981 12 with with IN cord-010092-uftc8inx 12981 13 transferrin transferrin NN cord-010092-uftc8inx 12981 14 % % NN cord-010092-uftc8inx 12981 15 of of IN cord-010092-uftc8inx 12981 16 < < XX cord-010092-uftc8inx 12981 17 20%/CRP 20%/crp CD cord-010092-uftc8inx 12982 1 > > XX cord-010092-uftc8inx 12983 1 5 5 CD cord-010092-uftc8inx 12983 2 mg mg NNP cord-010092-uftc8inx 12983 3 / / SYM cord-010092-uftc8inx 12983 4 L l NN cord-010092-uftc8inx 12983 5 -Anaemia -anaemia NN cord-010092-uftc8inx 12983 6 of of IN cord-010092-uftc8inx 12983 7 chronic chronic JJ cord-010092-uftc8inx 12983 8 inflammationserum inflammationserum NNP cord-010092-uftc8inx 12983 9 ferritin ferritin NN cord-010092-uftc8inx 12983 10 > > XX cord-010092-uftc8inx 12984 1 100 100 CD cord-010092-uftc8inx 12984 2 with with IN cord-010092-uftc8inx 12984 3 transferrin transferrin NN cord-010092-uftc8inx 12984 4 % % NN cord-010092-uftc8inx 12984 5 of of IN cord-010092-uftc8inx 12984 6 < < XX cord-010092-uftc8inx 12984 7 20%/CRP 20%/crp CD cord-010092-uftc8inx 12984 8 > > XX cord-010092-uftc8inx 12985 1 5 5 CD cord-010092-uftc8inx 12985 2 mg mg NNP cord-010092-uftc8inx 12985 3 / / SYM cord-010092-uftc8inx 12985 4 L L NNP cord-010092-uftc8inx 12985 5 Patients Patients NNP cord-010092-uftc8inx 12985 6 were be VBD cord-010092-uftc8inx 12985 7 considered consider VBN cord-010092-uftc8inx 12985 8 eligible eligible JJ cord-010092-uftc8inx 12985 9 for for IN cord-010092-uftc8inx 12985 10 IV IV NNP cord-010092-uftc8inx 12985 11 iron iron NN cord-010092-uftc8inx 12985 12 if if IN cord-010092-uftc8inx 12985 13 the the DT cord-010092-uftc8inx 12985 14 following follow VBG cord-010092-uftc8inx 12985 15 criteria criterion NNS cord-010092-uftc8inx 12985 16 were be VBD cord-010092-uftc8inx 12985 17 met:1 met:1 FW cord-010092-uftc8inx 12985 18 . . . cord-010092-uftc8inx 12986 1 An an DT cord-010092-uftc8inx 12986 2 inadequate inadequate JJ cord-010092-uftc8inx 12986 3 response response NN cord-010092-uftc8inx 12986 4 to to IN cord-010092-uftc8inx 12986 5 oral oral JJ cord-010092-uftc8inx 12986 6 iron iron NN cord-010092-uftc8inx 12986 7 , , , cord-010092-uftc8inx 12986 8 OR or CC cord-010092-uftc8inx 12986 9 were be VBD cord-010092-uftc8inx 12986 10 unable unable JJ cord-010092-uftc8inx 12986 11 to to TO cord-010092-uftc8inx 12986 12 tolerate tolerate VB cord-010092-uftc8inx 12986 13 oral oral JJ cord-010092-uftc8inx 12986 14 iron iron NN cord-010092-uftc8inx 12986 15 OR or CC cord-010092-uftc8inx 12986 16 the the DT cord-010092-uftc8inx 12986 17 interval interval NN cord-010092-uftc8inx 12986 18 between between IN cord-010092-uftc8inx 12986 19 diagnosis diagnosis NN cord-010092-uftc8inx 12986 20 and and CC cord-010092-uftc8inx 12986 21 surgery surgery NN cord-010092-uftc8inx 12986 22 was be VBD cord-010092-uftc8inx 12986 23 short short JJ cord-010092-uftc8inx 12986 24 2 2 CD cord-010092-uftc8inx 12986 25 . . . cord-010092-uftc8inx 12987 1 The the DT cord-010092-uftc8inx 12987 2 anaemia anaemia NN cord-010092-uftc8inx 12987 3 pro pro JJ cord-010092-uftc8inx 12987 4 - - JJ cord-010092-uftc8inx 12987 5 forma forma JJ cord-010092-uftc8inx 12987 6 was be VBD cord-010092-uftc8inx 12987 7 completed complete VBN cord-010092-uftc8inx 12987 8 3 3 CD cord-010092-uftc8inx 12987 9 . . . cord-010092-uftc8inx 12988 1 Hb Hb NNP cord-010092-uftc8inx 12988 2 was be VBD cord-010092-uftc8inx 12988 3 ≤ ≤ NNP cord-010092-uftc8inx 12988 4 120 120 CD cord-010092-uftc8inx 12988 5 g g NN cord-010092-uftc8inx 12988 6 / / SYM cord-010092-uftc8inx 12988 7 L L NNP cord-010092-uftc8inx 12988 8 4 4 CD cord-010092-uftc8inx 12988 9 . . . cord-010092-uftc8inx 12989 1 They -PRON- PRP cord-010092-uftc8inx 12989 2 were be VBD cord-010092-uftc8inx 12989 3 classified classify VBN cord-010092-uftc8inx 12989 4 as as IN cord-010092-uftc8inx 12989 5 either either DT cord-010092-uftc8inx 12989 6 having have VBG cord-010092-uftc8inx 12989 7 IDA IDA NNP cord-010092-uftc8inx 12989 8 OR or CC cord-010092-uftc8inx 12989 9 Chronic Chronic NNP cord-010092-uftc8inx 12989 10 Inflammation inflammation NN cord-010092-uftc8inx 12989 11 with with IN cord-010092-uftc8inx 12989 12 IDA IDA NNP cord-010092-uftc8inx 12989 13 OR or CC cord-010092-uftc8inx 12989 14 Anaemia Anaemia NNP cord-010092-uftc8inx 12989 15 of of IN cord-010092-uftc8inx 12989 16 chronic chronic JJ cord-010092-uftc8inx 12989 17 inflammation inflammation NN cord-010092-uftc8inx 12990 1 Hb Hb NNP cord-010092-uftc8inx 12990 2 was be VBD cord-010092-uftc8inx 12990 3 measured measure VBN cord-010092-uftc8inx 12990 4 prior prior RB cord-010092-uftc8inx 12990 5 and and CC cord-010092-uftc8inx 12990 6 on on IN cord-010092-uftc8inx 12990 7 average average JJ cord-010092-uftc8inx 12990 8 , , , cord-010092-uftc8inx 12990 9 20 20 CD cord-010092-uftc8inx 12990 10 days day NNS cord-010092-uftc8inx 12990 11 following follow VBG cord-010092-uftc8inx 12990 12 the the DT cord-010092-uftc8inx 12990 13 IV IV NNP cord-010092-uftc8inx 12990 14 iron iron NN cord-010092-uftc8inx 12990 15 infusion infusion NN cord-010092-uftc8inx 12990 16 . . . cord-010092-uftc8inx 12991 1 We -PRON- PRP cord-010092-uftc8inx 12991 2 excluded exclude VBD cord-010092-uftc8inx 12991 3 patients patient NNS cord-010092-uftc8inx 12991 4 who who WP cord-010092-uftc8inx 12991 5 had have VBD cord-010092-uftc8inx 12991 6 their -PRON- PRP$ cord-010092-uftc8inx 12991 7 post post NN cord-010092-uftc8inx 12991 8 IV IV NNP cord-010092-uftc8inx 12991 9 iron iron NN cord-010092-uftc8inx 12991 10 follow follow VBP cord-010092-uftc8inx 12991 11 up up RP cord-010092-uftc8inx 12991 12 blood blood NN cord-010092-uftc8inx 12991 13 tests test NNS cord-010092-uftc8inx 12991 14 done do VBN cord-010092-uftc8inx 12991 15 after after IN cord-010092-uftc8inx 12991 16 surgery surgery NN cord-010092-uftc8inx 12991 17 . . . cord-010092-uftc8inx 12992 1 Results result NNS cord-010092-uftc8inx 12992 2 : : : cord-010092-uftc8inx 12993 1 This this DT cord-010092-uftc8inx 12993 2 retrospective retrospective JJ cord-010092-uftc8inx 12993 3 evaluation evaluation NN cord-010092-uftc8inx 12993 4 included include VBD cord-010092-uftc8inx 12993 5 80 80 CD cord-010092-uftc8inx 12993 6 patients patient NNS cord-010092-uftc8inx 12993 7 . . . cord-010092-uftc8inx 12994 1 48 48 CD cord-010092-uftc8inx 12994 2 patients patient NNS cord-010092-uftc8inx 12994 3 were be VBD cord-010092-uftc8inx 12994 4 classified classify VBN cord-010092-uftc8inx 12994 5 as as IN cord-010092-uftc8inx 12994 6 having have VBG cord-010092-uftc8inx 12994 7 IDA IDA NNP cord-010092-uftc8inx 12994 8 and and CC cord-010092-uftc8inx 12994 9 32 32 CD cord-010092-uftc8inx 12994 10 patients patient NNS cord-010092-uftc8inx 12994 11 classified classify VBN cord-010092-uftc8inx 12994 12 as as IN cord-010092-uftc8inx 12994 13 having have VBG cord-010092-uftc8inx 12994 14 chronic chronic JJ cord-010092-uftc8inx 12994 15 inflammation inflammation NN cord-010092-uftc8inx 12994 16 with with IN cord-010092-uftc8inx 12994 17 IDA IDA NNP cord-010092-uftc8inx 12994 18 . . . cord-010092-uftc8inx 12995 1 Those those DT cord-010092-uftc8inx 12995 2 classified classify VBN cord-010092-uftc8inx 12995 3 with with IN cord-010092-uftc8inx 12995 4 IDA IDA NNP cord-010092-uftc8inx 12995 5 had have VBD cord-010092-uftc8inx 12995 6 a a DT cord-010092-uftc8inx 12995 7 mean mean JJ cord-010092-uftc8inx 12995 8 Hb Hb NNP cord-010092-uftc8inx 12995 9 of of IN cord-010092-uftc8inx 12995 10 96 96 CD cord-010092-uftc8inx 12995 11 g g NNP cord-010092-uftc8inx 12995 12 / / SYM cord-010092-uftc8inx 12995 13 L l NN cord-010092-uftc8inx 12995 14 ( ( -LRB- cord-010092-uftc8inx 12995 15 55 55 CD cord-010092-uftc8inx 12995 16 - - SYM cord-010092-uftc8inx 12995 17 120 120 CD cord-010092-uftc8inx 12995 18 ) ) -RRB- cord-010092-uftc8inx 12995 19 , , , cord-010092-uftc8inx 12995 20 a a DT cord-010092-uftc8inx 12995 21 mean mean JJ cord-010092-uftc8inx 12995 22 MCV MCV NNP cord-010092-uftc8inx 12995 23 of of IN cord-010092-uftc8inx 12995 24 77.4 77.4 CD cord-010092-uftc8inx 12995 25 fL fL NNP cord-010092-uftc8inx 12995 26 and and CC cord-010092-uftc8inx 12995 27 a a DT cord-010092-uftc8inx 12995 28 mean mean JJ cord-010092-uftc8inx 12995 29 serum serum NN cord-010092-uftc8inx 12995 30 ferritin ferritin NN cord-010092-uftc8inx 12995 31 of of IN cord-010092-uftc8inx 12995 32 16 16 CD cord-010092-uftc8inx 12995 33 lg lg NNP cord-010092-uftc8inx 12995 34 / / SYM cord-010092-uftc8inx 12995 35 L. L. NNP cord-010092-uftc8inx 12995 36 Those those DT cord-010092-uftc8inx 12995 37 with with IN cord-010092-uftc8inx 12995 38 chronic chronic JJ cord-010092-uftc8inx 12995 39 inflammation inflammation NN cord-010092-uftc8inx 12995 40 with with IN cord-010092-uftc8inx 12995 41 IDA IDA NNP cord-010092-uftc8inx 12996 1 had have VBD cord-010092-uftc8inx 12996 2 a a DT cord-010092-uftc8inx 12996 3 mean mean JJ cord-010092-uftc8inx 12996 4 Hb Hb NNP cord-010092-uftc8inx 12996 5 of of IN cord-010092-uftc8inx 12996 6 106 106 CD cord-010092-uftc8inx 12996 7 g g NN cord-010092-uftc8inx 12996 8 / / SYM cord-010092-uftc8inx 12996 9 L L NNP cord-010092-uftc8inx 12996 10 ( ( -LRB- cord-010092-uftc8inx 12996 11 77 77 CD cord-010092-uftc8inx 12996 12 - - SYM cord-010092-uftc8inx 12996 13 120 120 CD cord-010092-uftc8inx 12996 14 ) ) -RRB- cord-010092-uftc8inx 12996 15 , , , cord-010092-uftc8inx 12996 16 a a DT cord-010092-uftc8inx 12996 17 mean mean JJ cord-010092-uftc8inx 12996 18 MCV MCV NNP cord-010092-uftc8inx 12996 19 of of IN cord-010092-uftc8inx 12996 20 87.9 87.9 CD cord-010092-uftc8inx 12996 21 and and CC cord-010092-uftc8inx 12996 22 a a DT cord-010092-uftc8inx 12996 23 mean mean JJ cord-010092-uftc8inx 12996 24 serum serum NN cord-010092-uftc8inx 12996 25 ferritin ferritin NN cord-010092-uftc8inx 12996 26 of of IN cord-010092-uftc8inx 12996 27 57 57 CD cord-010092-uftc8inx 12996 28 lg lg NNP cord-010092-uftc8inx 12996 29 / / SYM cord-010092-uftc8inx 12996 30 L. L. NNP cord-010092-uftc8inx 12996 31 Follow Follow NNP cord-010092-uftc8inx 12996 32 - - HYPH cord-010092-uftc8inx 12996 33 up up NN cord-010092-uftc8inx 12997 1 Hb Hb NNP cord-010092-uftc8inx 12997 2 was be VBD cord-010092-uftc8inx 12997 3 measured measure VBN cord-010092-uftc8inx 12997 4 on on IN cord-010092-uftc8inx 12997 5 average average JJ cord-010092-uftc8inx 12997 6 twenty twenty CD cord-010092-uftc8inx 12997 7 days day NNS cord-010092-uftc8inx 12997 8 post post NN cord-010092-uftc8inx 12997 9 IV IV NNP cord-010092-uftc8inx 12997 10 iron iron NN cord-010092-uftc8inx 12997 11 infusion infusion NN cord-010092-uftc8inx 12997 12 in in IN cord-010092-uftc8inx 12997 13 both both DT cord-010092-uftc8inx 12997 14 groups group NNS cord-010092-uftc8inx 12997 15 . . . cord-010092-uftc8inx 12998 1 The the DT cord-010092-uftc8inx 12998 2 average average JJ cord-010092-uftc8inx 12998 3 Hb Hb NNP cord-010092-uftc8inx 12998 4 post post NN cord-010092-uftc8inx 12999 1 IV IV NNP cord-010092-uftc8inx 12999 2 iron iron NN cord-010092-uftc8inx 12999 3 infusion infusion NN cord-010092-uftc8inx 12999 4 in in IN cord-010092-uftc8inx 12999 5 the the DT cord-010092-uftc8inx 12999 6 IDA IDA NNP cord-010092-uftc8inx 12999 7 group group NN cord-010092-uftc8inx 12999 8 was be VBD cord-010092-uftc8inx 12999 9 119 119 CD cord-010092-uftc8inx 12999 10 g g NN cord-010092-uftc8inx 12999 11 / / SYM cord-010092-uftc8inx 12999 12 L L NNP cord-010092-uftc8inx 12999 13 ( ( -LRB- cord-010092-uftc8inx 12999 14 100 100 CD cord-010092-uftc8inx 12999 15 - - SYM cord-010092-uftc8inx 12999 16 149 149 CD cord-010092-uftc8inx 12999 17 ) ) -RRB- cord-010092-uftc8inx 12999 18 with with IN cord-010092-uftc8inx 12999 19 an an DT cord-010092-uftc8inx 12999 20 average average JJ cord-010092-uftc8inx 12999 21 increment increment NN cord-010092-uftc8inx 12999 22 of of IN cord-010092-uftc8inx 12999 23 23 23 CD cord-010092-uftc8inx 12999 24 g g NN cord-010092-uftc8inx 12999 25 / / SYM cord-010092-uftc8inx 12999 26 L L NNP cord-010092-uftc8inx 12999 27 and and CC cord-010092-uftc8inx 12999 28 in in IN cord-010092-uftc8inx 12999 29 the the DT cord-010092-uftc8inx 12999 30 group group NN cord-010092-uftc8inx 12999 31 with with IN cord-010092-uftc8inx 12999 32 chronic chronic JJ cord-010092-uftc8inx 12999 33 inflammation inflammation NN cord-010092-uftc8inx 12999 34 with with IN cord-010092-uftc8inx 12999 35 IDA IDA NNP cord-010092-uftc8inx 12999 36 the the DT cord-010092-uftc8inx 12999 37 average average JJ cord-010092-uftc8inx 12999 38 post post NN cord-010092-uftc8inx 13000 1 IV IV NNP cord-010092-uftc8inx 13000 2 iron iron NN cord-010092-uftc8inx 13000 3 Hb Hb NNP cord-010092-uftc8inx 13000 4 was be VBD cord-010092-uftc8inx 13000 5 117 117 CD cord-010092-uftc8inx 13000 6 g g NN cord-010092-uftc8inx 13000 7 / / SYM cord-010092-uftc8inx 13000 8 L l NN cord-010092-uftc8inx 13000 9 ( ( -LRB- cord-010092-uftc8inx 13000 10 85 85 CD cord-010092-uftc8inx 13000 11 - - SYM cord-010092-uftc8inx 13000 12 129 129 CD cord-010092-uftc8inx 13000 13 ) ) -RRB- cord-010092-uftc8inx 13000 14 with with IN cord-010092-uftc8inx 13000 15 an an DT cord-010092-uftc8inx 13000 16 average average JJ cord-010092-uftc8inx 13000 17 increment increment NN cord-010092-uftc8inx 13000 18 of of IN cord-010092-uftc8inx 13000 19 11 11 CD cord-010092-uftc8inx 13000 20 g g NNP cord-010092-uftc8inx 13000 21 / / SYM cord-010092-uftc8inx 13000 22 L. L. NNP cord-010092-uftc8inx 13000 23 Summary Summary NNP cord-010092-uftc8inx 13000 24 / / SYM cord-010092-uftc8inx 13000 25 Conclusions Conclusions NNPS cord-010092-uftc8inx 13000 26 : : : cord-010092-uftc8inx 13001 1 In in IN cord-010092-uftc8inx 13001 2 conclusion conclusion NN cord-010092-uftc8inx 13001 3 the the DT cord-010092-uftc8inx 13001 4 group group NN cord-010092-uftc8inx 13001 5 with with IN cord-010092-uftc8inx 13001 6 IDA IDA NNP cord-010092-uftc8inx 13001 7 had have VBD cord-010092-uftc8inx 13001 8 , , , cord-010092-uftc8inx 13001 9 on on IN cord-010092-uftc8inx 13001 10 average average JJ cord-010092-uftc8inx 13001 11 , , , cord-010092-uftc8inx 13001 12 a a DT cord-010092-uftc8inx 13001 13 lower low JJR cord-010092-uftc8inx 13001 14 starting start VBG cord-010092-uftc8inx 13001 15 Hb Hb NNP cord-010092-uftc8inx 13001 16 that that IN cord-010092-uftc8inx 13001 17 the the DT cord-010092-uftc8inx 13001 18 group group NN cord-010092-uftc8inx 13001 19 with with IN cord-010092-uftc8inx 13001 20 chronic chronic JJ cord-010092-uftc8inx 13001 21 inflammation inflammation NN cord-010092-uftc8inx 13001 22 with with IN cord-010092-uftc8inx 13001 23 IDA IDA NNP cord-010092-uftc8inx 13001 24 and and CC cord-010092-uftc8inx 13001 25 the the DT cord-010092-uftc8inx 13001 26 average average JJ cord-010092-uftc8inx 13001 27 increment increment NN cord-010092-uftc8inx 13001 28 in in IN cord-010092-uftc8inx 13001 29 Hb Hb NNP cord-010092-uftc8inx 13001 30 20 20 CD cord-010092-uftc8inx 13001 31 days day NNS cord-010092-uftc8inx 13001 32 post post NN cord-010092-uftc8inx 13001 33 IV IV NNP cord-010092-uftc8inx 13001 34 iron iron NN cord-010092-uftc8inx 13001 35 infusion infusion NN cord-010092-uftc8inx 13001 36 was be VBD cord-010092-uftc8inx 13001 37 greater great JJR cord-010092-uftc8inx 13001 38 in in IN cord-010092-uftc8inx 13001 39 the the DT cord-010092-uftc8inx 13001 40 group group NN cord-010092-uftc8inx 13001 41 with with IN cord-010092-uftc8inx 13001 42 IDA IDA NNP cord-010092-uftc8inx 13001 43 . . . cord-010092-uftc8inx 13002 1 However however RB cord-010092-uftc8inx 13002 2 , , , cord-010092-uftc8inx 13002 3 the the DT cord-010092-uftc8inx 13002 4 group group NN cord-010092-uftc8inx 13002 5 with with IN cord-010092-uftc8inx 13002 6 chronic chronic JJ cord-010092-uftc8inx 13002 7 inflammation inflammation NN cord-010092-uftc8inx 13002 8 with with IN cord-010092-uftc8inx 13002 9 IDA IDA NNP cord-010092-uftc8inx 13002 10 cases case NNS cord-010092-uftc8inx 13002 11 also also RB cord-010092-uftc8inx 13002 12 responded respond VBD cord-010092-uftc8inx 13002 13 to to IN cord-010092-uftc8inx 13002 14 IV IV NNP cord-010092-uftc8inx 13002 15 iron iron NN cord-010092-uftc8inx 13002 16 and and CC cord-010092-uftc8inx 13002 17 therefore therefore RB cord-010092-uftc8inx 13002 18 we -PRON- PRP cord-010092-uftc8inx 13002 19 strongly strongly RB cord-010092-uftc8inx 13002 20 consider consider VBP cord-010092-uftc8inx 13002 21 the the DT cord-010092-uftc8inx 13002 22 use use NN cord-010092-uftc8inx 13002 23 of of IN cord-010092-uftc8inx 13002 24 IV IV NNP cord-010092-uftc8inx 13002 25 iron iron NN cord-010092-uftc8inx 13002 26 in in IN cord-010092-uftc8inx 13002 27 both both DT cord-010092-uftc8inx 13002 28 groups group NNS cord-010092-uftc8inx 13002 29 . . . cord-010092-uftc8inx 13003 1 Further further JJ cord-010092-uftc8inx 13003 2 studies study NNS cord-010092-uftc8inx 13003 3 to to TO cord-010092-uftc8inx 13003 4 evaluate evaluate VB cord-010092-uftc8inx 13003 5 the the DT cord-010092-uftc8inx 13003 6 ongoing ongoing JJ cord-010092-uftc8inx 13003 7 effect effect NN cord-010092-uftc8inx 13003 8 of of IN cord-010092-uftc8inx 13003 9 IV IV NNP cord-010092-uftc8inx 13003 10 iron iron NN cord-010092-uftc8inx 13003 11 would would MD cord-010092-uftc8inx 13003 12 help help VB cord-010092-uftc8inx 13003 13 assess assess VB cord-010092-uftc8inx 13003 14 whether whether IN cord-010092-uftc8inx 13003 15 the the DT cord-010092-uftc8inx 13003 16 same same JJ cord-010092-uftc8inx 13003 17 level level NN cord-010092-uftc8inx 13003 18 of of IN cord-010092-uftc8inx 13003 19 increment increment NN cord-010092-uftc8inx 13003 20 seen see VBN cord-010092-uftc8inx 13003 21 with with IN cord-010092-uftc8inx 13003 22 IDA IDA NNP cord-010092-uftc8inx 13003 23 can can MD cord-010092-uftc8inx 13003 24 also also RB cord-010092-uftc8inx 13003 25 been be VBN cord-010092-uftc8inx 13003 26 seen see VBN cord-010092-uftc8inx 13003 27 for for IN cord-010092-uftc8inx 13003 28 the the DT cord-010092-uftc8inx 13003 29 group group NN cord-010092-uftc8inx 13003 30 with with IN cord-010092-uftc8inx 13003 31 chronic chronic JJ cord-010092-uftc8inx 13003 32 inflammation inflammation NN cord-010092-uftc8inx 13003 33 with with IN cord-010092-uftc8inx 13003 34 IDA IDA NNP cord-010092-uftc8inx 13003 35 over over IN cord-010092-uftc8inx 13003 36 a a DT cord-010092-uftc8inx 13003 37 longer long JJR cord-010092-uftc8inx 13003 38 period period NN cord-010092-uftc8inx 13003 39 and and CC cord-010092-uftc8inx 13003 40 how how WRB cord-010092-uftc8inx 13003 41 long long JJ cord-010092-uftc8inx 13003 42 the the DT cord-010092-uftc8inx 13003 43 increment increment NN cord-010092-uftc8inx 13003 44 was be VBD cord-010092-uftc8inx 13003 45 sustained sustain VBN cord-010092-uftc8inx 13003 46 . . . cord-010092-uftc8inx 13004 1 Background background NN cord-010092-uftc8inx 13004 2 : : : cord-010092-uftc8inx 13005 1 The the DT cord-010092-uftc8inx 13005 2 expansion expansion NN cord-010092-uftc8inx 13005 3 of of IN cord-010092-uftc8inx 13005 4 personalized personalized JJ cord-010092-uftc8inx 13005 5 genomic genomic JJ cord-010092-uftc8inx 13005 6 medicine medicine NN cord-010092-uftc8inx 13005 7 has have VBZ cord-010092-uftc8inx 13005 8 led lead VBN cord-010092-uftc8inx 13005 9 to to IN cord-010092-uftc8inx 13005 10 the the DT cord-010092-uftc8inx 13005 11 development development NN cord-010092-uftc8inx 13005 12 of of IN cord-010092-uftc8inx 13005 13 targeted target VBN cord-010092-uftc8inx 13005 14 therapeutic therapeutic JJ cord-010092-uftc8inx 13005 15 approaches approach NNS cord-010092-uftc8inx 13005 16 for for IN cord-010092-uftc8inx 13005 17 patients patient NNS cord-010092-uftc8inx 13005 18 . . . cord-010092-uftc8inx 13006 1 One one CD cord-010092-uftc8inx 13006 2 example example NN cord-010092-uftc8inx 13006 3 is be VBZ cord-010092-uftc8inx 13006 4 sipuleucel sipuleucel NNP cord-010092-uftc8inx 13006 5 - - HYPH cord-010092-uftc8inx 13006 6 T T NNP cord-010092-uftc8inx 13006 7 , , , cord-010092-uftc8inx 13006 8 an an DT cord-010092-uftc8inx 13006 9 autologous autologous JJ cord-010092-uftc8inx 13006 10 cellular cellular JJ cord-010092-uftc8inx 13006 11 immunotherapy immunotherapy NN cord-010092-uftc8inx 13006 12 product product NN cord-010092-uftc8inx 13006 13 used use VBN cord-010092-uftc8inx 13006 14 to to TO cord-010092-uftc8inx 13006 15 treat treat VB cord-010092-uftc8inx 13006 16 prostate prostate NN cord-010092-uftc8inx 13006 17 cancer cancer NN cord-010092-uftc8inx 13006 18 manufactured manufacture VBN cord-010092-uftc8inx 13006 19 from from IN cord-010092-uftc8inx 13006 20 the the DT cord-010092-uftc8inx 13006 21 patient patient NN cord-010092-uftc8inx 13006 22 's 's POS cord-010092-uftc8inx 13006 23 white white JJ cord-010092-uftc8inx 13006 24 blood blood NN cord-010092-uftc8inx 13006 25 cells cell NNS cord-010092-uftc8inx 13006 26 . . . cord-010092-uftc8inx 13007 1 This this DT cord-010092-uftc8inx 13007 2 study study NN cord-010092-uftc8inx 13007 3 describes describe VBZ cord-010092-uftc8inx 13007 4 our -PRON- PRP$ cord-010092-uftc8inx 13007 5 experience experience NN cord-010092-uftc8inx 13007 6 with with IN cord-010092-uftc8inx 13007 7 incorporating incorporate VBG cord-010092-uftc8inx 13007 8 autologous autologous JJ cord-010092-uftc8inx 13007 9 cellular cellular JJ cord-010092-uftc8inx 13007 10 immunotherapy immunotherapy NN cord-010092-uftc8inx 13007 11 products product NNS cord-010092-uftc8inx 13007 12 into into IN cord-010092-uftc8inx 13007 13 the the DT cord-010092-uftc8inx 13007 14 workflow workflow NN cord-010092-uftc8inx 13007 15 of of IN cord-010092-uftc8inx 13007 16 the the DT cord-010092-uftc8inx 13007 17 blood blood NN cord-010092-uftc8inx 13007 18 bank bank NN cord-010092-uftc8inx 13007 19 . . . cord-010092-uftc8inx 13008 1 The the DT cord-010092-uftc8inx 13008 2 policies policy NNS cord-010092-uftc8inx 13008 3 supporting support VBG cord-010092-uftc8inx 13008 4 the the DT cord-010092-uftc8inx 13008 5 workflow workflow NN cord-010092-uftc8inx 13008 6 are be VBP cord-010092-uftc8inx 13008 7 outlined outline VBN cord-010092-uftc8inx 13008 8 and and CC cord-010092-uftc8inx 13008 9 compliance compliance NN cord-010092-uftc8inx 13008 10 with with IN cord-010092-uftc8inx 13008 11 them -PRON- PRP cord-010092-uftc8inx 13008 12 is be VBZ cord-010092-uftc8inx 13008 13 assessed assess VBN cord-010092-uftc8inx 13008 14 . . . cord-010092-uftc8inx 13009 1 Aims aim VBZ cord-010092-uftc8inx 13009 2 : : : cord-010092-uftc8inx 13010 1 This this DT cord-010092-uftc8inx 13010 2 study study NN cord-010092-uftc8inx 13010 3 aims aim VBZ cord-010092-uftc8inx 13010 4 to to TO cord-010092-uftc8inx 13010 5 evaluate evaluate VB cord-010092-uftc8inx 13010 6 the the DT cord-010092-uftc8inx 13010 7 process process NN cord-010092-uftc8inx 13010 8 and and CC cord-010092-uftc8inx 13010 9 method method NN cord-010092-uftc8inx 13010 10 used use VBN cord-010092-uftc8inx 13010 11 to to TO cord-010092-uftc8inx 13010 12 dispense dispense VB cord-010092-uftc8inx 13010 13 and and CC cord-010092-uftc8inx 13010 14 track track VB cord-010092-uftc8inx 13010 15 the the DT cord-010092-uftc8inx 13010 16 infusion infusion NN cord-010092-uftc8inx 13010 17 of of IN cord-010092-uftc8inx 13010 18 sipuleucel sipuleucel NN cord-010092-uftc8inx 13010 19 - - HYPH cord-010092-uftc8inx 13010 20 T. t. NN cord-010092-uftc8inx 13010 21 Methods method NNS cord-010092-uftc8inx 13010 22 : : : cord-010092-uftc8inx 13010 23 This this DT cord-010092-uftc8inx 13010 24 is be VBZ cord-010092-uftc8inx 13010 25 a a DT cord-010092-uftc8inx 13010 26 retrospective retrospective JJ cord-010092-uftc8inx 13010 27 analysis analysis NN cord-010092-uftc8inx 13010 28 of of IN cord-010092-uftc8inx 13010 29 the the DT cord-010092-uftc8inx 13010 30 dispensation dispensation NN cord-010092-uftc8inx 13010 31 and and CC cord-010092-uftc8inx 13010 32 administration administration NN cord-010092-uftc8inx 13010 33 of of IN cord-010092-uftc8inx 13010 34 sipuleucel sipuleucel NNP cord-010092-uftc8inx 13010 35 - - HYPH cord-010092-uftc8inx 13010 36 T T NNP cord-010092-uftc8inx 13010 37 from from IN cord-010092-uftc8inx 13010 38 January January NNP cord-010092-uftc8inx 13010 39 2012-August 2012-august CD cord-010092-uftc8inx 13010 40 2018 2018 CD cord-010092-uftc8inx 13010 41 , , , cord-010092-uftc8inx 13010 42 which which WDT cord-010092-uftc8inx 13010 43 was be VBD cord-010092-uftc8inx 13010 44 handled handle VBN cord-010092-uftc8inx 13010 45 exclusively exclusively RB cord-010092-uftc8inx 13010 46 by by IN cord-010092-uftc8inx 13010 47 the the DT cord-010092-uftc8inx 13010 48 blood blood NN cord-010092-uftc8inx 13010 49 bank bank NN cord-010092-uftc8inx 13010 50 . . . cord-010092-uftc8inx 13011 1 Standard standard JJ cord-010092-uftc8inx 13011 2 operating operating NN cord-010092-uftc8inx 13011 3 procedures procedure NNS cord-010092-uftc8inx 13011 4 and and CC cord-010092-uftc8inx 13011 5 hospital hospital NN cord-010092-uftc8inx 13011 6 policies policy NNS cord-010092-uftc8inx 13011 7 were be VBD cord-010092-uftc8inx 13011 8 reviewed review VBN cord-010092-uftc8inx 13011 9 and and CC cord-010092-uftc8inx 13011 10 compliance compliance NN cord-010092-uftc8inx 13011 11 with with IN cord-010092-uftc8inx 13011 12 these these DT cord-010092-uftc8inx 13011 13 policies policy NNS cord-010092-uftc8inx 13011 14 evaluated evaluate VBN cord-010092-uftc8inx 13011 15 . . . cord-010092-uftc8inx 13012 1 Included include VBN cord-010092-uftc8inx 13012 2 were be VBD cord-010092-uftc8inx 13012 3 patients patient NNS cord-010092-uftc8inx 13012 4 who who WP cord-010092-uftc8inx 13012 5 had have VBD cord-010092-uftc8inx 13012 6 the the DT cord-010092-uftc8inx 13012 7 sipuleucel sipuleucel NNP cord-010092-uftc8inx 13012 8 - - HYPH cord-010092-uftc8inx 13012 9 T T NNP cord-010092-uftc8inx 13012 10 product product NN cord-010092-uftc8inx 13012 11 dispensed dispense VBN cord-010092-uftc8inx 13012 12 and and CC cord-010092-uftc8inx 13012 13 administered administer VBN cord-010092-uftc8inx 13012 14 . . . cord-010092-uftc8inx 13013 1 Information information NN cord-010092-uftc8inx 13013 2 collected collect VBN cord-010092-uftc8inx 13013 3 included include VBD cord-010092-uftc8inx 13013 4 the the DT cord-010092-uftc8inx 13013 5 total total JJ cord-010092-uftc8inx 13013 6 number number NN cord-010092-uftc8inx 13013 7 of of IN cord-010092-uftc8inx 13013 8 products product NNS cord-010092-uftc8inx 13013 9 dispensed dispense VBN cord-010092-uftc8inx 13013 10 , , , cord-010092-uftc8inx 13013 11 patient patient JJ cord-010092-uftc8inx 13013 12 age age NN cord-010092-uftc8inx 13013 13 , , , cord-010092-uftc8inx 13013 14 adverse adverse JJ cord-010092-uftc8inx 13013 15 reactions reaction NNS cord-010092-uftc8inx 13013 16 / / SYM cord-010092-uftc8inx 13013 17 incidents incident NNS cord-010092-uftc8inx 13013 18 , , , cord-010092-uftc8inx 13013 19 premedication premedication NN cord-010092-uftc8inx 13013 20 , , , cord-010092-uftc8inx 13013 21 and and CC cord-010092-uftc8inx 13013 22 patient patient JJ cord-010092-uftc8inx 13013 23 outcome outcome NN cord-010092-uftc8inx 13013 24 . . . cord-010092-uftc8inx 13014 1 Descriptive descriptive JJ cord-010092-uftc8inx 13014 2 statistics statistic NNS cord-010092-uftc8inx 13014 3 were be VBD cord-010092-uftc8inx 13014 4 used use VBN cord-010092-uftc8inx 13014 5 for for IN cord-010092-uftc8inx 13014 6 data datum NNS cord-010092-uftc8inx 13014 7 analysis analysis NN cord-010092-uftc8inx 13014 8 . . . cord-010092-uftc8inx 13015 1 Results result NNS cord-010092-uftc8inx 13015 2 : : : cord-010092-uftc8inx 13016 1 There there EX cord-010092-uftc8inx 13016 2 were be VBD cord-010092-uftc8inx 13016 3 154 154 CD cord-010092-uftc8inx 13016 4 products product NNS cord-010092-uftc8inx 13016 5 dispensed dispense VBN cord-010092-uftc8inx 13016 6 to to IN cord-010092-uftc8inx 13016 7 53 53 CD cord-010092-uftc8inx 13016 8 patients patient NNS cord-010092-uftc8inx 13016 9 . . . cord-010092-uftc8inx 13017 1 The the DT cord-010092-uftc8inx 13017 2 recipients recipient NNS cord-010092-uftc8inx 13017 3 were be VBD cord-010092-uftc8inx 13017 4 male male JJ cord-010092-uftc8inx 13017 5 patients patient NNS cord-010092-uftc8inx 13017 6 diagnosed diagnose VBN cord-010092-uftc8inx 13017 7 with with IN cord-010092-uftc8inx 13017 8 prostate prostate NN cord-010092-uftc8inx 13017 9 cancer cancer NN cord-010092-uftc8inx 13017 10 with with IN cord-010092-uftc8inx 13017 11 a a DT cord-010092-uftc8inx 13017 12 mean mean JJ cord-010092-uftc8inx 13017 13 age age NN cord-010092-uftc8inx 13017 14 of of IN cord-010092-uftc8inx 13017 15 74 74 CD cord-010092-uftc8inx 13017 16 years year NNS cord-010092-uftc8inx 13017 17 . . . cord-010092-uftc8inx 13018 1 There there EX cord-010092-uftc8inx 13018 2 were be VBD cord-010092-uftc8inx 13018 3 3 3 CD cord-010092-uftc8inx 13018 4 doses dose NNS cord-010092-uftc8inx 13018 5 ( ( -LRB- cord-010092-uftc8inx 13018 6 a a DT cord-010092-uftc8inx 13018 7 complete complete JJ cord-010092-uftc8inx 13018 8 course course NN cord-010092-uftc8inx 13018 9 ) ) -RRB- cord-010092-uftc8inx 13018 10 administered administer VBN cord-010092-uftc8inx 13018 11 to to IN cord-010092-uftc8inx 13018 12 50/53 50/53 CD cord-010092-uftc8inx 13018 13 ( ( -LRB- cord-010092-uftc8inx 13018 14 94 94 CD cord-010092-uftc8inx 13018 15 % % NN cord-010092-uftc8inx 13018 16 ) ) -RRB- cord-010092-uftc8inx 13018 17 recipients recipient NNS cord-010092-uftc8inx 13018 18 and and CC cord-010092-uftc8inx 13018 19 a a DT cord-010092-uftc8inx 13018 20 partial partial JJ cord-010092-uftc8inx 13018 21 course course NN cord-010092-uftc8inx 13018 22 ( ( -LRB- cord-010092-uftc8inx 13018 23 1 1 CD cord-010092-uftc8inx 13018 24 - - SYM cord-010092-uftc8inx 13018 25 2 2 CD cord-010092-uftc8inx 13018 26 doses dose NNS cord-010092-uftc8inx 13018 27 ) ) -RRB- cord-010092-uftc8inx 13018 28 administered administer VBN cord-010092-uftc8inx 13018 29 to to IN cord-010092-uftc8inx 13018 30 3/50 3/50 NNP cord-010092-uftc8inx 13018 31 ( ( -LRB- cord-010092-uftc8inx 13018 32 6 6 CD cord-010092-uftc8inx 13018 33 % % NN cord-010092-uftc8inx 13018 34 ) ) -RRB- cord-010092-uftc8inx 13018 35 recipients recipient NNS cord-010092-uftc8inx 13018 36 , , , cord-010092-uftc8inx 13018 37 for for IN cord-010092-uftc8inx 13018 38 a a DT cord-010092-uftc8inx 13018 39 total total NN cord-010092-uftc8inx 13018 40 of of IN cord-010092-uftc8inx 13018 41 154 154 CD cord-010092-uftc8inx 13018 42 products product NNS cord-010092-uftc8inx 13018 43 . . . cord-010092-uftc8inx 13019 1 The the DT cord-010092-uftc8inx 13019 2 blood blood NN cord-010092-uftc8inx 13019 3 bank bank NN cord-010092-uftc8inx 13019 4 workflow workflow NN cord-010092-uftc8inx 13019 5 treated treat VBD cord-010092-uftc8inx 13019 6 sipuleucel sipuleucel NNP cord-010092-uftc8inx 13019 7 - - HYPH cord-010092-uftc8inx 13019 8 T T NNP cord-010092-uftc8inx 13019 9 as as IN cord-010092-uftc8inx 13019 10 a a DT cord-010092-uftc8inx 13019 11 derivative derivative NN cord-010092-uftc8inx 13019 12 in in IN cord-010092-uftc8inx 13019 13 the the DT cord-010092-uftc8inx 13019 14 computer computer NN cord-010092-uftc8inx 13019 15 system system NN cord-010092-uftc8inx 13019 16 , , , cord-010092-uftc8inx 13019 17 listing list VBG cord-010092-uftc8inx 13019 18 the the DT cord-010092-uftc8inx 13019 19 manufacturer manufacturer NN cord-010092-uftc8inx 13019 20 ( ( -LRB- cord-010092-uftc8inx 13019 21 Dendreon Dendreon NNP cord-010092-uftc8inx 13019 22 Corporation Corporation NNP cord-010092-uftc8inx 13019 23 ) ) -RRB- cord-010092-uftc8inx 13019 24 as as IN cord-010092-uftc8inx 13019 25 the the DT cord-010092-uftc8inx 13019 26 supplier supplier NN cord-010092-uftc8inx 13019 27 . . . cord-010092-uftc8inx 13020 1 Health health NN cord-010092-uftc8inx 13020 2 care care NN cord-010092-uftc8inx 13020 3 providers provider NNS cord-010092-uftc8inx 13020 4 were be VBD cord-010092-uftc8inx 13020 5 instructed instruct VBN cord-010092-uftc8inx 13020 6 to to TO cord-010092-uftc8inx 13020 7 follow follow VB cord-010092-uftc8inx 13020 8 the the DT cord-010092-uftc8inx 13020 9 nursing nursing NN cord-010092-uftc8inx 13020 10 policy policy NN cord-010092-uftc8inx 13020 11 for for IN cord-010092-uftc8inx 13020 12 the the DT cord-010092-uftc8inx 13020 13 administration administration NN cord-010092-uftc8inx 13020 14 of of IN cord-010092-uftc8inx 13020 15 blood blood NN cord-010092-uftc8inx 13020 16 products product NNS cord-010092-uftc8inx 13020 17 and and CC cord-010092-uftc8inx 13020 18 derivatives derivative NNS cord-010092-uftc8inx 13020 19 for for IN cord-010092-uftc8inx 13020 20 the the DT cord-010092-uftc8inx 13020 21 infusion infusion NN cord-010092-uftc8inx 13020 22 of of IN cord-010092-uftc8inx 13021 1 sipuleucel sipuleucel NNP cord-010092-uftc8inx 13021 2 - - HYPH cord-010092-uftc8inx 13021 3 T. T. NNP cord-010092-uftc8inx 13021 4 This this DT cord-010092-uftc8inx 13021 5 policy policy NN cord-010092-uftc8inx 13021 6 required require VBN cord-010092-uftc8inx 13021 7 documentation documentation NN cord-010092-uftc8inx 13021 8 of of IN cord-010092-uftc8inx 13021 9 the the DT cord-010092-uftc8inx 13021 10 infusion infusion NN cord-010092-uftc8inx 13021 11 in in IN cord-010092-uftc8inx 13021 12 a a DT cord-010092-uftc8inx 13021 13 transfusion transfusion NN cord-010092-uftc8inx 13021 14 nursing nursing NN cord-010092-uftc8inx 13021 15 note note NN cord-010092-uftc8inx 13021 16 and and CC cord-010092-uftc8inx 13021 17 reporting report VBG cord-010092-uftc8inx 13021 18 adverse adverse JJ cord-010092-uftc8inx 13021 19 events event NNS cord-010092-uftc8inx 13021 20 to to IN cord-010092-uftc8inx 13021 21 the the DT cord-010092-uftc8inx 13021 22 blood blood NN cord-010092-uftc8inx 13021 23 bank bank NN cord-010092-uftc8inx 13021 24 as as IN cord-010092-uftc8inx 13021 25 transfusion transfusion NN cord-010092-uftc8inx 13021 26 reactions reaction NNS cord-010092-uftc8inx 13021 27 . . . cord-010092-uftc8inx 13022 1 There there EX cord-010092-uftc8inx 13022 2 were be VBD cord-010092-uftc8inx 13022 3 no no DT cord-010092-uftc8inx 13022 4 adverse adverse JJ cord-010092-uftc8inx 13022 5 events event NNS cord-010092-uftc8inx 13022 6 reported report VBN cord-010092-uftc8inx 13022 7 to to IN cord-010092-uftc8inx 13022 8 the the DT cord-010092-uftc8inx 13022 9 blood blood NN cord-010092-uftc8inx 13022 10 bank bank NN cord-010092-uftc8inx 13022 11 , , , cord-010092-uftc8inx 13022 12 yet yet CC cord-010092-uftc8inx 13022 13 there there EX cord-010092-uftc8inx 13022 14 were be VBD cord-010092-uftc8inx 13022 15 5 5 CD cord-010092-uftc8inx 13022 16 adverse adverse JJ cord-010092-uftc8inx 13022 17 events event NNS cord-010092-uftc8inx 13022 18 described describe VBN cord-010092-uftc8inx 13022 19 in in IN cord-010092-uftc8inx 13022 20 provider provider NN cord-010092-uftc8inx 13022 21 notes note NNS cord-010092-uftc8inx 13022 22 ; ; : cord-010092-uftc8inx 13022 23 2 2 CD cord-010092-uftc8inx 13022 24 of of IN cord-010092-uftc8inx 13022 25 them -PRON- PRP cord-010092-uftc8inx 13022 26 necessitating necessitate VBG cord-010092-uftc8inx 13022 27 transfer transfer NN cord-010092-uftc8inx 13022 28 to to IN cord-010092-uftc8inx 13022 29 the the DT cord-010092-uftc8inx 13022 30 Emergency Emergency NNP cord-010092-uftc8inx 13022 31 Department Department NNP cord-010092-uftc8inx 13022 32 , , , cord-010092-uftc8inx 13022 33 and and CC cord-010092-uftc8inx 13022 34 1 1 CD cord-010092-uftc8inx 13022 35 requiring require VBG cord-010092-uftc8inx 13022 36 hospital hospital NN cord-010092-uftc8inx 13022 37 admission admission NN cord-010092-uftc8inx 13022 38 . . . cord-010092-uftc8inx 13023 1 Of of IN cord-010092-uftc8inx 13023 2 the the DT cord-010092-uftc8inx 13023 3 154 154 CD cord-010092-uftc8inx 13023 4 infusions infusion NNS cord-010092-uftc8inx 13023 5 , , , cord-010092-uftc8inx 13023 6 6 6 CD cord-010092-uftc8inx 13023 7 infusions infusion NNS cord-010092-uftc8inx 13023 8 were be VBD cord-010092-uftc8inx 13023 9 documented document VBN cord-010092-uftc8inx 13023 10 in in IN cord-010092-uftc8inx 13023 11 a a DT cord-010092-uftc8inx 13023 12 chemotherapy chemotherapy NN cord-010092-uftc8inx 13023 13 note note NN cord-010092-uftc8inx 13023 14 rather rather RB cord-010092-uftc8inx 13023 15 than than IN cord-010092-uftc8inx 13023 16 a a DT cord-010092-uftc8inx 13023 17 transfusion transfusion NN cord-010092-uftc8inx 13023 18 note note NN cord-010092-uftc8inx 13023 19 ( ( -LRB- cord-010092-uftc8inx 13023 20 4 4 CD cord-010092-uftc8inx 13023 21 % % NN cord-010092-uftc8inx 13023 22 ) ) -RRB- cord-010092-uftc8inx 13023 23 , , , cord-010092-uftc8inx 13023 24 and and CC cord-010092-uftc8inx 13023 25 59 59 CD cord-010092-uftc8inx 13023 26 ( ( -LRB- cord-010092-uftc8inx 13023 27 38 38 CD cord-010092-uftc8inx 13023 28 % % NN cord-010092-uftc8inx 13023 29 ) ) -RRB- cord-010092-uftc8inx 13023 30 were be VBD cord-010092-uftc8inx 13023 31 documented document VBN cord-010092-uftc8inx 13023 32 as as IN cord-010092-uftc8inx 13023 33 both both CC cord-010092-uftc8inx 13023 34 a a DT cord-010092-uftc8inx 13023 35 transfusion transfusion NN cord-010092-uftc8inx 13023 36 and and CC cord-010092-uftc8inx 13023 37 a a DT cord-010092-uftc8inx 13023 38 chemotherapy chemotherapy NN cord-010092-uftc8inx 13023 39 administration administration NN cord-010092-uftc8inx 13023 40 . . . cord-010092-uftc8inx 13024 1 There there EX cord-010092-uftc8inx 13024 2 were be VBD cord-010092-uftc8inx 13024 3 6 6 CD cord-010092-uftc8inx 13024 4 additional additional JJ cord-010092-uftc8inx 13024 5 deviations deviation NNS cord-010092-uftc8inx 13024 6 from from IN cord-010092-uftc8inx 13024 7 the the DT cord-010092-uftc8inx 13024 8 blood blood NN cord-010092-uftc8inx 13024 9 product product NN cord-010092-uftc8inx 13024 10 administration administration NN cord-010092-uftc8inx 13024 11 policy policy NN cord-010092-uftc8inx 13024 12 : : : cord-010092-uftc8inx 13024 13 2 2 CD cord-010092-uftc8inx 13024 14 cases case NNS cord-010092-uftc8inx 13024 15 where where WRB cord-010092-uftc8inx 13024 16 the the DT cord-010092-uftc8inx 13024 17 consent consent NN cord-010092-uftc8inx 13024 18 check check NN cord-010092-uftc8inx 13024 19 was be VBD cord-010092-uftc8inx 13024 20 not not RB cord-010092-uftc8inx 13024 21 performed perform VBN cord-010092-uftc8inx 13024 22 , , , cord-010092-uftc8inx 13024 23 1 1 CD cord-010092-uftc8inx 13024 24 case case NN cord-010092-uftc8inx 13024 25 where where WRB cord-010092-uftc8inx 13024 26 the the DT cord-010092-uftc8inx 13024 27 product product NN cord-010092-uftc8inx 13024 28 was be VBD cord-010092-uftc8inx 13024 29 infused infuse VBN cord-010092-uftc8inx 13024 30 with with IN cord-010092-uftc8inx 13024 31 Ringer Ringer NNP cord-010092-uftc8inx 13024 32 's 's POS cord-010092-uftc8inx 13024 33 Lactate Lactate NNP cord-010092-uftc8inx 13024 34 rather rather RB cord-010092-uftc8inx 13024 35 than than IN cord-010092-uftc8inx 13024 36 normal normal JJ cord-010092-uftc8inx 13024 37 saline saline NN cord-010092-uftc8inx 13024 38 , , , cord-010092-uftc8inx 13024 39 and and CC cord-010092-uftc8inx 13024 40 3 3 CD cord-010092-uftc8inx 13024 41 cases case NNS cord-010092-uftc8inx 13024 42 where where WRB cord-010092-uftc8inx 13024 43 the the DT cord-010092-uftc8inx 13024 44 2-person 2-person CD cord-010092-uftc8inx 13024 45 3-way 3-way NN cord-010092-uftc8inx 13024 46 check check NN cord-010092-uftc8inx 13024 47 erroneously erroneously RB cord-010092-uftc8inx 13024 48 indicated indicate VBD cord-010092-uftc8inx 13024 49 the the DT cord-010092-uftc8inx 13024 50 product product NN cord-010092-uftc8inx 13024 51 was be VBD cord-010092-uftc8inx 13024 52 irradiated irradiate VBN cord-010092-uftc8inx 13024 53 . . . cord-010092-uftc8inx 13025 1 Summary Summary NNP cord-010092-uftc8inx 13025 2 / / SYM cord-010092-uftc8inx 13025 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 13025 4 : : : cord-010092-uftc8inx 13026 1 This this DT cord-010092-uftc8inx 13026 2 study study NN cord-010092-uftc8inx 13026 3 describes describe VBZ cord-010092-uftc8inx 13026 4 one one CD cord-010092-uftc8inx 13026 5 approach approach NN cord-010092-uftc8inx 13026 6 to to IN cord-010092-uftc8inx 13026 7 managing manage VBG cord-010092-uftc8inx 13026 8 cellular cellular JJ cord-010092-uftc8inx 13026 9 therapy therapy NN cord-010092-uftc8inx 13026 10 products product NNS cord-010092-uftc8inx 13026 11 as as IN cord-010092-uftc8inx 13026 12 an an DT cord-010092-uftc8inx 13026 13 extension extension NN cord-010092-uftc8inx 13026 14 to to IN cord-010092-uftc8inx 13026 15 existing exist VBG cord-010092-uftc8inx 13026 16 blood blood NN cord-010092-uftc8inx 13026 17 products product NNS cord-010092-uftc8inx 13026 18 dispensed dispense VBN cord-010092-uftc8inx 13026 19 by by IN cord-010092-uftc8inx 13026 20 a a DT cord-010092-uftc8inx 13026 21 blood blood NN cord-010092-uftc8inx 13026 22 bank bank NN cord-010092-uftc8inx 13026 23 . . . cord-010092-uftc8inx 13027 1 The the DT cord-010092-uftc8inx 13027 2 findings finding NNS cord-010092-uftc8inx 13027 3 demonstrate demonstrate VBP cord-010092-uftc8inx 13027 4 noncompliance noncompliance NN cord-010092-uftc8inx 13027 5 with with IN cord-010092-uftc8inx 13027 6 hospital hospital NN cord-010092-uftc8inx 13027 7 policy policy NN cord-010092-uftc8inx 13027 8 with with IN cord-010092-uftc8inx 13027 9 this this DT cord-010092-uftc8inx 13027 10 new new JJ cord-010092-uftc8inx 13027 11 product product NN cord-010092-uftc8inx 13027 12 as as IN cord-010092-uftc8inx 13027 13 evidenced evidence VBN cord-010092-uftc8inx 13027 14 by by IN cord-010092-uftc8inx 13027 15 failure failure NN cord-010092-uftc8inx 13027 16 to to TO cord-010092-uftc8inx 13027 17 report report VB cord-010092-uftc8inx 13027 18 adverse adverse JJ cord-010092-uftc8inx 13027 19 events event NNS cord-010092-uftc8inx 13027 20 and and CC cord-010092-uftc8inx 13027 21 failure failure NN cord-010092-uftc8inx 13027 22 to to TO cord-010092-uftc8inx 13027 23 follow follow VB cord-010092-uftc8inx 13027 24 hospital hospital NN cord-010092-uftc8inx 13027 25 practices practice NNS cord-010092-uftc8inx 13027 26 regarding regard VBG cord-010092-uftc8inx 13027 27 administration administration NN cord-010092-uftc8inx 13027 28 . . . cord-010092-uftc8inx 13028 1 Although although IN cord-010092-uftc8inx 13028 2 sipuleucel sipuleucel NNP cord-010092-uftc8inx 13028 3 - - HYPH cord-010092-uftc8inx 13028 4 T T NNP cord-010092-uftc8inx 13028 5 is be VBZ cord-010092-uftc8inx 13028 6 a a DT cord-010092-uftc8inx 13028 7 product product NN cord-010092-uftc8inx 13028 8 manufactured manufacture VBN cord-010092-uftc8inx 13028 9 from from IN cord-010092-uftc8inx 13028 10 an an DT cord-010092-uftc8inx 13028 11 autologous autologous JJ cord-010092-uftc8inx 13028 12 blood blood NN cord-010092-uftc8inx 13028 13 product product NN cord-010092-uftc8inx 13028 14 donation donation NN cord-010092-uftc8inx 13028 15 , , , cord-010092-uftc8inx 13028 16 the the DT cord-010092-uftc8inx 13028 17 administration administration NN cord-010092-uftc8inx 13028 18 and and CC cord-010092-uftc8inx 13028 19 perceptions perception NNS cord-010092-uftc8inx 13028 20 of of IN cord-010092-uftc8inx 13028 21 this this DT cord-010092-uftc8inx 13028 22 product product NN cord-010092-uftc8inx 13028 23 may may MD cord-010092-uftc8inx 13028 24 be be VB cord-010092-uftc8inx 13028 25 more more RBR cord-010092-uftc8inx 13028 26 similar similar JJ cord-010092-uftc8inx 13028 27 to to IN cord-010092-uftc8inx 13028 28 a a DT cord-010092-uftc8inx 13028 29 pharmaceutical pharmaceutical NN cord-010092-uftc8inx 13028 30 . . . cord-010092-uftc8inx 13029 1 As as IN cord-010092-uftc8inx 13029 2 the the DT cord-010092-uftc8inx 13029 3 field field NN cord-010092-uftc8inx 13029 4 of of IN cord-010092-uftc8inx 13029 5 immunotherapies immunotherapy NNS cord-010092-uftc8inx 13029 6 derived derive VBN cord-010092-uftc8inx 13029 7 from from IN cord-010092-uftc8inx 13029 8 blood blood NN cord-010092-uftc8inx 13029 9 product product NN cord-010092-uftc8inx 13029 10 donations donation NNS cord-010092-uftc8inx 13029 11 continues continue VBZ cord-010092-uftc8inx 13029 12 to to TO cord-010092-uftc8inx 13029 13 expand expand VB cord-010092-uftc8inx 13029 14 , , , cord-010092-uftc8inx 13029 15 these these DT cord-010092-uftc8inx 13029 16 products product NNS cord-010092-uftc8inx 13029 17 may may MD cord-010092-uftc8inx 13029 18 necessitate necessitate VB cord-010092-uftc8inx 13029 19 an an DT cord-010092-uftc8inx 13029 20 entirely entirely RB cord-010092-uftc8inx 13029 21 new new JJ cord-010092-uftc8inx 13029 22 approach approach NN cord-010092-uftc8inx 13029 23 to to TO cord-010092-uftc8inx 13029 24 ensure ensure VB cord-010092-uftc8inx 13029 25 proper proper JJ cord-010092-uftc8inx 13029 26 management management NN cord-010092-uftc8inx 13029 27 . . . cord-010092-uftc8inx 13030 1 Abstract Abstract NNP cord-010092-uftc8inx 13030 2 withdrawn withdraw VBN cord-010092-uftc8inx 13030 3 . . . cord-010092-uftc8inx 13031 1 ( ( -LRB- cord-010092-uftc8inx 13031 2 REF ref NN cord-010092-uftc8inx 13031 3 10310 10310 CD cord-010092-uftc8inx 13031 4 ) ) -RRB- cord-010092-uftc8inx 13031 5 . . . cord-010092-uftc8inx 13032 1 While while IN cord-010092-uftc8inx 13032 2 the the DT cord-010092-uftc8inx 13032 3 MNC MNC NNP cord-010092-uftc8inx 13032 4 procedure procedure NN cord-010092-uftc8inx 13032 5 is be VBZ cord-010092-uftc8inx 13032 6 fully fully RB cord-010092-uftc8inx 13032 7 automated automate VBN cord-010092-uftc8inx 13032 8 , , , cord-010092-uftc8inx 13032 9 CMNC CMNC NNP cord-010092-uftc8inx 13032 10 requires require VBZ cord-010092-uftc8inx 13032 11 frequent frequent JJ cord-010092-uftc8inx 13032 12 interface interface NN cord-010092-uftc8inx 13032 13 checks check NNS cord-010092-uftc8inx 13032 14 to to TO cord-010092-uftc8inx 13032 15 ensure ensure VB cord-010092-uftc8inx 13032 16 the the DT cord-010092-uftc8inx 13032 17 collection collection NN cord-010092-uftc8inx 13032 18 of of IN cord-010092-uftc8inx 13032 19 the the DT cord-010092-uftc8inx 13032 20 correct correct JJ cord-010092-uftc8inx 13032 21 cell cell NN cord-010092-uftc8inx 13032 22 layer layer NN cord-010092-uftc8inx 13032 23 . . . cord-010092-uftc8inx 13033 1 At at IN cord-010092-uftc8inx 13033 2 the the DT cord-010092-uftc8inx 13033 3 Rambam Rambam NNP cord-010092-uftc8inx 13033 4 Health Health NNP cord-010092-uftc8inx 13033 5 Care Care NNP cord-010092-uftc8inx 13033 6 Campus Campus NNP cord-010092-uftc8inx 13033 7 , , , cord-010092-uftc8inx 13033 8 a a DT cord-010092-uftc8inx 13033 9 tertiary tertiary JJ cord-010092-uftc8inx 13033 10 care care NN cord-010092-uftc8inx 13033 11 center center NN cord-010092-uftc8inx 13033 12 , , , cord-010092-uftc8inx 13033 13 solely solely RB cord-010092-uftc8inx 13033 14 the the DT cord-010092-uftc8inx 13033 15 MNC MNC NNP cord-010092-uftc8inx 13033 16 procedure procedure NN cord-010092-uftc8inx 13033 17 had have VBD cord-010092-uftc8inx 13033 18 been be VBN cord-010092-uftc8inx 13033 19 employed employ VBN cord-010092-uftc8inx 13033 20 till till IN cord-010092-uftc8inx 13033 21 2017 2017 CD cord-010092-uftc8inx 13033 22 , , , cord-010092-uftc8inx 13033 23 at at IN cord-010092-uftc8inx 13033 24 which which WDT cord-010092-uftc8inx 13033 25 point point NN cord-010092-uftc8inx 13033 26 , , , cord-010092-uftc8inx 13033 27 the the DT cord-010092-uftc8inx 13033 28 CMNC CMNC NNP cord-010092-uftc8inx 13033 29 has have VBZ cord-010092-uftc8inx 13033 30 been be VBN cord-010092-uftc8inx 13033 31 introduced introduce VBN cord-010092-uftc8inx 13033 32 for for IN cord-010092-uftc8inx 13033 33 the the DT cord-010092-uftc8inx 13033 34 use use NN cord-010092-uftc8inx 13033 35 in in IN cord-010092-uftc8inx 13033 36 patients patient NNS cord-010092-uftc8inx 13033 37 with with IN cord-010092-uftc8inx 13033 38 a a DT cord-010092-uftc8inx 13033 39 white white JJ cord-010092-uftc8inx 13033 40 blood blood NN cord-010092-uftc8inx 13033 41 cell cell NN cord-010092-uftc8inx 13033 42 ( ( -LRB- cord-010092-uftc8inx 13033 43 WBC WBC NNP cord-010092-uftc8inx 13033 44 ) ) -RRB- cord-010092-uftc8inx 13033 45 count count NN cord-010092-uftc8inx 13033 46 of of IN cord-010092-uftc8inx 13033 47 ≥ ≥ CD cord-010092-uftc8inx 13033 48 20,000 20,000 CD cord-010092-uftc8inx 13033 49 / / SYM cord-010092-uftc8inx 13033 50 lL ll ADD cord-010092-uftc8inx 13033 51 on on IN cord-010092-uftc8inx 13033 52 the the DT cord-010092-uftc8inx 13033 53 collection collection NN cord-010092-uftc8inx 13033 54 day day NN cord-010092-uftc8inx 13033 55 . . . cord-010092-uftc8inx 13034 1 Aims aim VBZ cord-010092-uftc8inx 13034 2 : : : cord-010092-uftc8inx 13035 1 The the DT cord-010092-uftc8inx 13035 2 current current JJ cord-010092-uftc8inx 13035 3 study study NN cord-010092-uftc8inx 13035 4 aimed aim VBN cord-010092-uftc8inx 13035 5 to to TO cord-010092-uftc8inx 13035 6 compare compare VB cord-010092-uftc8inx 13035 7 various various JJ cord-010092-uftc8inx 13035 8 parameters parameter NNS cord-010092-uftc8inx 13035 9 of of IN cord-010092-uftc8inx 13035 10 peripheral peripheral JJ cord-010092-uftc8inx 13035 11 blood blood NN cord-010092-uftc8inx 13035 12 stem stem NN cord-010092-uftc8inx 13035 13 cell cell NN cord-010092-uftc8inx 13035 14 ( ( -LRB- cord-010092-uftc8inx 13035 15 PBSC PBSC NNP cord-010092-uftc8inx 13035 16 ) ) -RRB- cord-010092-uftc8inx 13035 17 collection collection NN cord-010092-uftc8inx 13035 18 , , , cord-010092-uftc8inx 13035 19 using use VBG cord-010092-uftc8inx 13035 20 the the DT cord-010092-uftc8inx 13035 21 CMNC CMNC NNP cord-010092-uftc8inx 13035 22 protocol protocol NN cord-010092-uftc8inx 13035 23 in in IN cord-010092-uftc8inx 13035 24 allogeneic allogeneic NN cord-010092-uftc8inx 13035 25 donors donor NNS cord-010092-uftc8inx 13035 26 and and CC cord-010092-uftc8inx 13035 27 patients patient NNS cord-010092-uftc8inx 13035 28 undergoing undergo VBG cord-010092-uftc8inx 13035 29 autologous autologous JJ cord-010092-uftc8inx 13035 30 stem stem NN cord-010092-uftc8inx 13035 31 cell cell NN cord-010092-uftc8inx 13035 32 ( ( -LRB- cord-010092-uftc8inx 13035 33 AutoSC AutoSC NNP cord-010092-uftc8inx 13035 34 ) ) -RRB- cord-010092-uftc8inx 13035 35 transplantation transplantation NN cord-010092-uftc8inx 13035 36 . . . cord-010092-uftc8inx 13036 1 Additionally additionally RB cord-010092-uftc8inx 13036 2 , , , cord-010092-uftc8inx 13036 3 data datum NNS cord-010092-uftc8inx 13036 4 on on IN cord-010092-uftc8inx 13036 5 AutoSC AutoSC NNP cord-010092-uftc8inx 13036 6 collection collection NN cord-010092-uftc8inx 13036 7 using use VBG cord-010092-uftc8inx 13036 8 MNC MNC NNP cord-010092-uftc8inx 13036 9 ( ( -LRB- cord-010092-uftc8inx 13036 10 n n NN cord-010092-uftc8inx 13036 11 = = SYM cord-010092-uftc8inx 13036 12 31 31 CD cord-010092-uftc8inx 13036 13 ) ) -RRB- cord-010092-uftc8inx 13036 14 and and CC cord-010092-uftc8inx 13036 15 CMNC CMNC NNP cord-010092-uftc8inx 13036 16 ( ( -LRB- cord-010092-uftc8inx 13036 17 n n NN cord-010092-uftc8inx 13036 18 = = SYM cord-010092-uftc8inx 13036 19 88 88 CD cord-010092-uftc8inx 13036 20 ) ) -RRB- cord-010092-uftc8inx 13036 21 procedures procedure NNS cord-010092-uftc8inx 13036 22 were be VBD cord-010092-uftc8inx 13036 23 compared compare VBN cord-010092-uftc8inx 13036 24 . . . cord-010092-uftc8inx 13037 1 Methods method NNS cord-010092-uftc8inx 13037 2 : : : cord-010092-uftc8inx 13038 1 Data datum NNS cord-010092-uftc8inx 13038 2 were be VBD cord-010092-uftc8inx 13038 3 retrospectively retrospectively RB cord-010092-uftc8inx 13038 4 obtained obtain VBN cord-010092-uftc8inx 13038 5 from from IN cord-010092-uftc8inx 13038 6 PBSC PBSC NNP cord-010092-uftc8inx 13038 7 collection collection NN cord-010092-uftc8inx 13038 8 reports report NNS cord-010092-uftc8inx 13038 9 in in IN cord-010092-uftc8inx 13038 10 134 134 CD cord-010092-uftc8inx 13038 11 consecutive consecutive JJ cord-010092-uftc8inx 13038 12 CMNC CMNC NNP cord-010092-uftc8inx 13038 13 procedures procedure NNS cord-010092-uftc8inx 13038 14 , , , cord-010092-uftc8inx 13038 15 including include VBG cord-010092-uftc8inx 13038 16 88 88 CD cord-010092-uftc8inx 13038 17 autologous autologous JJ cord-010092-uftc8inx 13038 18 and and CC cord-010092-uftc8inx 13038 19 46 46 CD cord-010092-uftc8inx 13038 20 allogeneic allogeneic NN cord-010092-uftc8inx 13038 21 donors donor NNS cord-010092-uftc8inx 13038 22 . . . cord-010092-uftc8inx 13039 1 The the DT cord-010092-uftc8inx 13039 2 following following JJ cord-010092-uftc8inx 13039 3 comparisons comparison NNS cord-010092-uftc8inx 13039 4 were be VBD cord-010092-uftc8inx 13039 5 made make VBN cord-010092-uftc8inx 13039 6 : : : cord-010092-uftc8inx 13039 7 CMNC cmnc NN cord-010092-uftc8inx 13039 8 results result NNS cord-010092-uftc8inx 13039 9 of of IN cord-010092-uftc8inx 13039 10 allogeneic allogeneic NN cord-010092-uftc8inx 13039 11 versus versus IN cord-010092-uftc8inx 13039 12 autologous autologous JJ cord-010092-uftc8inx 13039 13 donors donor NNS cord-010092-uftc8inx 13039 14 , , , cord-010092-uftc8inx 13039 15 a a DT cord-010092-uftc8inx 13039 16 sub sub NN cord-010092-uftc8inx 13039 17 - - NN cord-010092-uftc8inx 13039 18 analysis analysis NN cord-010092-uftc8inx 13039 19 of of IN cord-010092-uftc8inx 13039 20 CMNC CMNC NNP cord-010092-uftc8inx 13039 21 results result NNS cord-010092-uftc8inx 13039 22 for for IN cord-010092-uftc8inx 13039 23 autologous autologous JJ cord-010092-uftc8inx 13039 24 donors donor NNS cord-010092-uftc8inx 13039 25 with with IN cord-010092-uftc8inx 13039 26 a a DT cord-010092-uftc8inx 13039 27 PB PB NNP cord-010092-uftc8inx 13039 28 CD34 CD34 NNP cord-010092-uftc8inx 13039 29 + + CC cord-010092-uftc8inx 13039 30 count count NN cord-010092-uftc8inx 13040 1 ≥20 ≥20 NNP cord-010092-uftc8inx 13040 2 / / SYM cord-010092-uftc8inx 13040 3 lL lL NNP cord-010092-uftc8inx 13040 4 versus versus IN cord-010092-uftc8inx 13040 5 allogeneic allogeneic IN cord-010092-uftc8inx 13040 6 donors donor NNS cord-010092-uftc8inx 13040 7 as as RB cord-010092-uftc8inx 13040 8 well well RB cord-010092-uftc8inx 13040 9 as as IN cord-010092-uftc8inx 13040 10 MNC MNC NNP cord-010092-uftc8inx 13040 11 versus versus IN cord-010092-uftc8inx 13040 12 CMNC CMNC NNP cord-010092-uftc8inx 13040 13 results result NNS cord-010092-uftc8inx 13040 14 in in IN cord-010092-uftc8inx 13040 15 autologous autologous JJ cord-010092-uftc8inx 13040 16 donors donor NNS cord-010092-uftc8inx 13040 17 . . . cord-010092-uftc8inx 13041 1 The the DT cord-010092-uftc8inx 13041 2 collection collection NN cord-010092-uftc8inx 13041 3 efficiency-2 efficiency-2 NNP cord-010092-uftc8inx 13041 4 ( ( -LRB- cord-010092-uftc8inx 13041 5 CE-2 CE-2 NNP cord-010092-uftc8inx 13041 6 ) ) -RRB- cord-010092-uftc8inx 13041 7 was be VBD cord-010092-uftc8inx 13041 8 defined define VBN cord-010092-uftc8inx 13041 9 as as IN cord-010092-uftc8inx 13041 10 the the DT cord-010092-uftc8inx 13041 11 total total JJ cord-010092-uftc8inx 13041 12 CD34 CD34 NNP cord-010092-uftc8inx 13041 13 + + CC cord-010092-uftc8inx 13041 14 amount amount NN cord-010092-uftc8inx 13041 15 in in IN cord-010092-uftc8inx 13041 16 the the DT cord-010092-uftc8inx 13041 17 collection collection NN cord-010092-uftc8inx 13041 18 bag bag NN cord-010092-uftc8inx 13041 19 divided divide VBN cord-010092-uftc8inx 13041 20 by by IN cord-010092-uftc8inx 13041 21 the the DT cord-010092-uftc8inx 13041 22 amount amount NN cord-010092-uftc8inx 13041 23 of of IN cord-010092-uftc8inx 13041 24 CD34 CD34 NNP cord-010092-uftc8inx 13041 25 + + CC cord-010092-uftc8inx 13041 26 cells cell NNS cord-010092-uftc8inx 13041 27 in in IN cord-010092-uftc8inx 13041 28 the the DT cord-010092-uftc8inx 13041 29 PB PB NNP cord-010092-uftc8inx 13041 30 processed process VBN cord-010092-uftc8inx 13041 31 by by IN cord-010092-uftc8inx 13041 32 the the DT cord-010092-uftc8inx 13041 33 collection collection NN cord-010092-uftc8inx 13041 34 apparatus apparatus NN cord-010092-uftc8inx 13041 35 . . . cord-010092-uftc8inx 13042 1 Results result NNS cord-010092-uftc8inx 13042 2 : : : cord-010092-uftc8inx 13043 1 In in IN cord-010092-uftc8inx 13043 2 the the DT cord-010092-uftc8inx 13043 3 CMNC CMNC NNP cord-010092-uftc8inx 13043 4 , , , cord-010092-uftc8inx 13043 5 the the DT cord-010092-uftc8inx 13043 6 following follow VBG cord-010092-uftc8inx 13043 7 parameters parameter NNS cord-010092-uftc8inx 13043 8 significantly significantly RB cord-010092-uftc8inx 13043 9 differed differ VBD cord-010092-uftc8inx 13043 10 between between IN cord-010092-uftc8inx 13043 11 autologous autologous JJ cord-010092-uftc8inx 13043 12 and and CC cord-010092-uftc8inx 13043 13 allogeneic allogeneic IN cord-010092-uftc8inx 13043 14 donors donor NNS cord-010092-uftc8inx 13043 15 : : : cord-010092-uftc8inx 13043 16 mean mean VB cord-010092-uftc8inx 13043 17 collection collection NN cord-010092-uftc8inx 13043 18 time time NN cord-010092-uftc8inx 13043 19 ( ( -LRB- cord-010092-uftc8inx 13043 20 333 333 CD cord-010092-uftc8inx 13043 21 AE AE NNP cord-010092-uftc8inx 13043 22 59 59 CD cord-010092-uftc8inx 13043 23 and and CC cord-010092-uftc8inx 13043 24 289 289 CD cord-010092-uftc8inx 13043 25 AE AE NNP cord-010092-uftc8inx 13043 26 73 73 CD cord-010092-uftc8inx 13043 27 min min NN cord-010092-uftc8inx 13043 28 , , , cord-010092-uftc8inx 13043 29 respectively respectively RB cord-010092-uftc8inx 13043 30 ; ; : cord-010092-uftc8inx 13043 31 P p NN cord-010092-uftc8inx 13043 32 = = SYM cord-010092-uftc8inx 13043 33 0.001 0.001 CD cord-010092-uftc8inx 13043 34 ) ) -RRB- cord-010092-uftc8inx 13043 35 , , , cord-010092-uftc8inx 13043 36 the the DT cord-010092-uftc8inx 13043 37 total total JJ cord-010092-uftc8inx 13043 38 blood blood NN cord-010092-uftc8inx 13043 39 volume volume NN cord-010092-uftc8inx 13043 40 processed process VBN cord-010092-uftc8inx 13043 41 ( ( -LRB- cord-010092-uftc8inx 13043 42 3.4 3.4 CD cord-010092-uftc8inx 13043 43 AE AE NNP cord-010092-uftc8inx 13043 44 0.8 0.8 CD cord-010092-uftc8inx 13043 45 and and CC cord-010092-uftc8inx 13043 46 2.4 2.4 CD cord-010092-uftc8inx 13043 47 AE AE NNP cord-010092-uftc8inx 13043 48 0.8 0.8 CD cord-010092-uftc8inx 13043 49 , , , cord-010092-uftc8inx 13043 50 respectively respectively RB cord-010092-uftc8inx 13043 51 ; ; : cord-010092-uftc8inx 13043 52 P p NN cord-010092-uftc8inx 13043 53 = = SYM cord-010092-uftc8inx 13043 54 0.001 0.001 CD cord-010092-uftc8inx 13043 55 ) ) -RRB- cord-010092-uftc8inx 13043 56 and and CC cord-010092-uftc8inx 13043 57 the the DT cord-010092-uftc8inx 13043 58 final final JJ cord-010092-uftc8inx 13043 59 volume volume NN cord-010092-uftc8inx 13043 60 in in IN cord-010092-uftc8inx 13043 61 the the DT cord-010092-uftc8inx 13043 62 collection collection NN cord-010092-uftc8inx 13043 63 bag bag NN cord-010092-uftc8inx 13043 64 ( ( -LRB- cord-010092-uftc8inx 13043 65 337 337 CD cord-010092-uftc8inx 13043 66 AE AE NNP cord-010092-uftc8inx 13043 67 77 77 CD cord-010092-uftc8inx 13043 68 and and CC cord-010092-uftc8inx 13043 69 291 291 CD cord-010092-uftc8inx 13043 70 AE AE NNP cord-010092-uftc8inx 13043 71 84 84 CD cord-010092-uftc8inx 13043 72 mL ml NN cord-010092-uftc8inx 13043 73 ; ; : cord-010092-uftc8inx 13043 74 P p NN cord-010092-uftc8inx 13043 75 = = SYM cord-010092-uftc8inx 13043 76 0.001 0.001 CD cord-010092-uftc8inx 13043 77 ) ) -RRB- cord-010092-uftc8inx 13043 78 . . . cord-010092-uftc8inx 13044 1 The the DT cord-010092-uftc8inx 13044 2 mean mean NN cord-010092-uftc8inx 13044 3 CE-2 CE-2 NNP cord-010092-uftc8inx 13044 4 in in IN cord-010092-uftc8inx 13044 5 autologous autologous JJ cord-010092-uftc8inx 13044 6 versus versus IN cord-010092-uftc8inx 13044 7 allogeneic allogeneic IN cord-010092-uftc8inx 13044 8 donors donor NNS cord-010092-uftc8inx 13044 9 was be VBD cord-010092-uftc8inx 13044 10 49 49 CD cord-010092-uftc8inx 13044 11 AE AE NNP cord-010092-uftc8inx 13044 12 24 24 CD cord-010092-uftc8inx 13044 13 and and CC cord-010092-uftc8inx 13044 14 66 66 CD cord-010092-uftc8inx 13044 15 AE AE NNP cord-010092-uftc8inx 13044 16 22 22 CD cord-010092-uftc8inx 13044 17 , , , cord-010092-uftc8inx 13044 18 respectively respectively RB cord-010092-uftc8inx 13044 19 ( ( -LRB- cord-010092-uftc8inx 13044 20 P p NN cord-010092-uftc8inx 13044 21 = = SYM cord-010092-uftc8inx 13044 22 0.003 0.003 CD cord-010092-uftc8inx 13044 23 ) ) -RRB- cord-010092-uftc8inx 13044 24 . . . cord-010092-uftc8inx 13045 1 Using use VBG cord-010092-uftc8inx 13045 2 CMNC CMNC NNP cord-010092-uftc8inx 13045 3 , , , cord-010092-uftc8inx 13045 4 the the DT cord-010092-uftc8inx 13045 5 collection collection NN cord-010092-uftc8inx 13045 6 was be VBD cord-010092-uftc8inx 13045 7 effective effective JJ cord-010092-uftc8inx 13045 8 in in IN cord-010092-uftc8inx 13045 9 94 94 CD cord-010092-uftc8inx 13045 10 % % NN cord-010092-uftc8inx 13045 11 of of IN cord-010092-uftc8inx 13045 12 allogeneic allogeneic NN cord-010092-uftc8inx 13045 13 and and CC cord-010092-uftc8inx 13045 14 63 63 CD cord-010092-uftc8inx 13045 15 % % NN cord-010092-uftc8inx 13045 16 of of IN cord-010092-uftc8inx 13045 17 autologous autologous JJ cord-010092-uftc8inx 13045 18 donors donor NNS cord-010092-uftc8inx 13045 19 . . . cord-010092-uftc8inx 13046 1 In in IN cord-010092-uftc8inx 13046 2 autologous autologous JJ cord-010092-uftc8inx 13046 3 donors donor NNS cord-010092-uftc8inx 13046 4 , , , cord-010092-uftc8inx 13046 5 a a DT cord-010092-uftc8inx 13046 6 significantly significantly RB cord-010092-uftc8inx 13046 7 lower low JJR cord-010092-uftc8inx 13046 8 collection collection NN cord-010092-uftc8inx 13046 9 bag bag NN cord-010092-uftc8inx 13046 10 volume volume NN cord-010092-uftc8inx 13046 11 ( ( -LRB- cord-010092-uftc8inx 13046 12 341 341 CD cord-010092-uftc8inx 13046 13 AE AE NNP cord-010092-uftc8inx 13046 14 84 84 CD cord-010092-uftc8inx 13046 15 and and CC cord-010092-uftc8inx 13046 16 396 396 CD cord-010092-uftc8inx 13046 17 AE AE NNP cord-010092-uftc8inx 13046 18 132 132 CD cord-010092-uftc8inx 13046 19 , , , cord-010092-uftc8inx 13046 20 respectively respectively RB cord-010092-uftc8inx 13046 21 ; ; : cord-010092-uftc8inx 13046 22 P p NN cord-010092-uftc8inx 13046 23 < < XX cord-010092-uftc8inx 13046 24 0.01 0.01 CD cord-010092-uftc8inx 13046 25 ) ) -RRB- cord-010092-uftc8inx 13046 26 and and CC cord-010092-uftc8inx 13046 27 increased increase VBD cord-010092-uftc8inx 13046 28 total total JJ cord-010092-uftc8inx 13046 29 WBC WBC NNP cord-010092-uftc8inx 13046 30 in in IN cord-010092-uftc8inx 13046 31 the the DT cord-010092-uftc8inx 13046 32 collection collection NN cord-010092-uftc8inx 13046 33 bag bag NN cord-010092-uftc8inx 13046 34 ( ( -LRB- cord-010092-uftc8inx 13046 35 263 263 CD cord-010092-uftc8inx 13046 36 AE AE NNP cord-010092-uftc8inx 13046 37 119 119 CD cord-010092-uftc8inx 13046 38 versus versus IN cord-010092-uftc8inx 13046 39 149 149 CD cord-010092-uftc8inx 13046 40 AE AE NNP cord-010092-uftc8inx 13046 41 36 36 CD cord-010092-uftc8inx 13046 42 , , , cord-010092-uftc8inx 13046 43 respectively respectively RB cord-010092-uftc8inx 13046 44 ; ; : cord-010092-uftc8inx 13046 45 P p NN cord-010092-uftc8inx 13046 46 < < XX cord-010092-uftc8inx 13046 47 0.000 0.000 CD cord-010092-uftc8inx 13046 48 ) ) -RRB- cord-010092-uftc8inx 13046 49 were be VBD cord-010092-uftc8inx 13046 50 obtained obtain VBN cord-010092-uftc8inx 13046 51 using use VBG cord-010092-uftc8inx 13046 52 CMNC CMNC NNP cord-010092-uftc8inx 13046 53 compared compare VBN cord-010092-uftc8inx 13046 54 to to IN cord-010092-uftc8inx 13046 55 MNC MNC NNP cord-010092-uftc8inx 13046 56 protocol protocol NN cord-010092-uftc8inx 13046 57 . . . cord-010092-uftc8inx 13047 1 Thirteen thirteen CD cord-010092-uftc8inx 13047 2 patients patient NNS cord-010092-uftc8inx 13047 3 were be VBD cord-010092-uftc8inx 13047 4 treated treat VBN cord-010092-uftc8inx 13047 5 with with IN cord-010092-uftc8inx 13047 6 plerixafor plerixafor NN cord-010092-uftc8inx 13047 7 due due IN cord-010092-uftc8inx 13047 8 to to IN cord-010092-uftc8inx 13047 9 a a DT cord-010092-uftc8inx 13047 10 low low JJ cord-010092-uftc8inx 13047 11 PB PB NNP cord-010092-uftc8inx 13047 12 CD34 CD34 NNP cord-010092-uftc8inx 13047 13 + + CC cord-010092-uftc8inx 13047 14 count count NN cord-010092-uftc8inx 13047 15 following follow VBG cord-010092-uftc8inx 13047 16 G G NNP cord-010092-uftc8inx 13047 17 - - HYPH cord-010092-uftc8inx 13047 18 CSF csf NN cord-010092-uftc8inx 13047 19 therapy therapy NN cord-010092-uftc8inx 13047 20 ; ; : cord-010092-uftc8inx 13047 21 7 7 CD cord-010092-uftc8inx 13047 22 of of IN cord-010092-uftc8inx 13047 23 them -PRON- PRP cord-010092-uftc8inx 13047 24 achieved achieve VBD cord-010092-uftc8inx 13047 25 a a DT cord-010092-uftc8inx 13047 26 CD34 CD34 NNP cord-010092-uftc8inx 13047 27 count count NN cord-010092-uftc8inx 13047 28 ≥20 ≥20 NNP cord-010092-uftc8inx 13047 29 and and CC cord-010092-uftc8inx 13047 30 their -PRON- PRP$ cord-010092-uftc8inx 13047 31 collection collection NN cord-010092-uftc8inx 13047 32 was be VBD cord-010092-uftc8inx 13047 33 considered consider VBN cord-010092-uftc8inx 13047 34 effective effective JJ cord-010092-uftc8inx 13047 35 . . . cord-010092-uftc8inx 13048 1 Summary Summary NNP cord-010092-uftc8inx 13048 2 / / SYM cord-010092-uftc8inx 13048 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 13048 4 : : : cord-010092-uftc8inx 13049 1 The the DT cord-010092-uftc8inx 13049 2 CMNC CMNC NNP cord-010092-uftc8inx 13049 3 protocol protocol NN cord-010092-uftc8inx 13049 4 is be VBZ cord-010092-uftc8inx 13049 5 highly highly RB cord-010092-uftc8inx 13049 6 effective effective JJ cord-010092-uftc8inx 13049 7 in in IN cord-010092-uftc8inx 13049 8 terms term NNS cord-010092-uftc8inx 13049 9 of of IN cord-010092-uftc8inx 13049 10 the the DT cord-010092-uftc8inx 13049 11 cell cell NN cord-010092-uftc8inx 13049 12 yield yield NN cord-010092-uftc8inx 13049 13 in in IN cord-010092-uftc8inx 13049 14 both both CC cord-010092-uftc8inx 13049 15 allogeneic allogeneic JJ cord-010092-uftc8inx 13049 16 and and CC cord-010092-uftc8inx 13049 17 autologous autologous JJ cord-010092-uftc8inx 13049 18 donors donor NNS cord-010092-uftc8inx 13049 19 with with IN cord-010092-uftc8inx 13049 20 a a DT cord-010092-uftc8inx 13049 21 PB PB NNP cord-010092-uftc8inx 13049 22 CD34 CD34 NNP cord-010092-uftc8inx 13049 23 + + CC cord-010092-uftc8inx 13049 24 count count NN cord-010092-uftc8inx 13049 25 ≥ ≥ CD cord-010092-uftc8inx 13049 26 20 20 CD cord-010092-uftc8inx 13050 1 /lL. /lL. NFP cord-010092-uftc8inx 13050 2 Significantly significantly RB cord-010092-uftc8inx 13050 3 superior superior JJ cord-010092-uftc8inx 13050 4 collection collection NN cord-010092-uftc8inx 13050 5 results result NNS cord-010092-uftc8inx 13050 6 are be VBP cord-010092-uftc8inx 13050 7 obtained obtain VBN cord-010092-uftc8inx 13050 8 in in IN cord-010092-uftc8inx 13050 9 allogeneic allogeneic NN cord-010092-uftc8inx 13050 10 donors donor NNS cord-010092-uftc8inx 13050 11 versus versus IN cord-010092-uftc8inx 13050 12 autologous autologous JJ cord-010092-uftc8inx 13050 13 ones one NNS cord-010092-uftc8inx 13050 14 . . . cord-010092-uftc8inx 13051 1 CMNC CMNC NNP cord-010092-uftc8inx 13051 2 provides provide VBZ cord-010092-uftc8inx 13051 3 a a DT cord-010092-uftc8inx 13051 4 significantly significantly RB cord-010092-uftc8inx 13051 5 higher high JJR cord-010092-uftc8inx 13051 6 WBC WBC NNP cord-010092-uftc8inx 13051 7 and and CC cord-010092-uftc8inx 13051 8 a a DT cord-010092-uftc8inx 13051 9 lower low JJR cord-010092-uftc8inx 13051 10 final final JJ cord-010092-uftc8inx 13051 11 collection collection NN cord-010092-uftc8inx 13051 12 volume volume NN cord-010092-uftc8inx 13051 13 than than IN cord-010092-uftc8inx 13051 14 MNC MNC NNP cord-010092-uftc8inx 13051 15 . . . cord-010092-uftc8inx 13052 1 Similar similar JJ cord-010092-uftc8inx 13052 2 total total NN cord-010092-uftc8inx 13053 1 CD34 CD34 NNP cord-010092-uftc8inx 13053 2 + + CC cord-010092-uftc8inx 13053 3 cell cell NN cord-010092-uftc8inx 13053 4 counts count NNS cord-010092-uftc8inx 13053 5 are be VBP cord-010092-uftc8inx 13053 6 obtained obtain VBN cord-010092-uftc8inx 13053 7 with with IN cord-010092-uftc8inx 13053 8 both both DT cord-010092-uftc8inx 13053 9 methods method NNS cord-010092-uftc8inx 13053 10 . . . cord-010092-uftc8inx 13053 11 . . . cord-010092-uftc8inx 13054 1 TBV tbv NN cord-010092-uftc8inx 13054 2 processed process VBN cord-010092-uftc8inx 13054 3 ranged range VBD cord-010092-uftc8inx 13054 4 from from IN cord-010092-uftc8inx 13054 5 1 1 CD cord-010092-uftc8inx 13054 6 - - SYM cord-010092-uftc8inx 13054 7 4.8 4.8 CD cord-010092-uftc8inx 13054 8 TBV tbv NN cord-010092-uftc8inx 13054 9 with with IN cord-010092-uftc8inx 13054 10 mean mean NN cord-010092-uftc8inx 13054 11 of of IN cord-010092-uftc8inx 13054 12 2.6 2.6 CD cord-010092-uftc8inx 13054 13 , , , cord-010092-uftc8inx 13054 14 average average JJ cord-010092-uftc8inx 13054 15 was be VBD cord-010092-uftc8inx 13054 16 2.65 2.65 CD cord-010092-uftc8inx 13054 17 TBV tbv NN cord-010092-uftc8inx 13054 18 for for IN cord-010092-uftc8inx 13054 19 females female NNS cord-010092-uftc8inx 13054 20 and and CC cord-010092-uftc8inx 13054 21 2.74 2.74 CD cord-010092-uftc8inx 13054 22 TBV tbv NN cord-010092-uftc8inx 13054 23 for for IN cord-010092-uftc8inx 13054 24 males male NNS cord-010092-uftc8inx 13055 1 Mean mean JJ cord-010092-uftc8inx 13055 2 pre pre JJ cord-010092-uftc8inx 13055 3 - - JJ cord-010092-uftc8inx 13055 4 apheresis apheresis NN cord-010092-uftc8inx 13055 5 CD34 CD34 NNP cord-010092-uftc8inx 13056 1 + + CC cord-010092-uftc8inx 13056 2 count count NN cord-010092-uftc8inx 13056 3 was be VBD cord-010092-uftc8inx 13056 4 92.89 92.89 CD cord-010092-uftc8inx 13056 5 cells/ cells/ CD cord-010092-uftc8inx 13057 1 ll will VB cord-010092-uftc8inx 13058 1 ( ( -LRB- cord-010092-uftc8inx 13058 2 Range Range NNP cord-010092-uftc8inx 13058 3 33.14 33.14 CD cord-010092-uftc8inx 13058 4 - - SYM cord-010092-uftc8inx 13058 5 152.64 152.64 CD cord-010092-uftc8inx 13058 6 ) ) -RRB- cord-010092-uftc8inx 13058 7 . . . cord-010092-uftc8inx 13059 1 Mean mean JJ cord-010092-uftc8inx 13059 2 postapheresis postapheresis NN cord-010092-uftc8inx 13059 3 CD34 CD34 NNP cord-010092-uftc8inx 13060 1 + + CC cord-010092-uftc8inx 13060 2 count count NN cord-010092-uftc8inx 13060 3 was be VBD cord-010092-uftc8inx 13060 4 1402.3 1402.3 CD cord-010092-uftc8inx 13060 5 cells/ cells/ CD cord-010092-uftc8inx 13061 1 ll will UH cord-010092-uftc8inx 13061 2 ( ( -LRB- cord-010092-uftc8inx 13061 3 559.02 559.02 CD cord-010092-uftc8inx 13061 4 - - SYM cord-010092-uftc8inx 13061 5 2245.5 2245.5 CD cord-010092-uftc8inx 13061 6 ) ) -RRB- cord-010092-uftc8inx 13061 7 . . . cord-010092-uftc8inx 13062 1 Mean mean JJ cord-010092-uftc8inx 13062 2 CD34 CD34 NNP cord-010092-uftc8inx 13062 3 + + CC cord-010092-uftc8inx 13062 4 cells cell NNS cord-010092-uftc8inx 13062 5 x10 x10 CD cord-010092-uftc8inx 13062 6 6 6 CD cord-010092-uftc8inx 13062 7 / / SYM cord-010092-uftc8inx 13062 8 kg kg NN cord-010092-uftc8inx 13063 1 recipients recipient NNS cord-010092-uftc8inx 13063 2 body body NN cord-010092-uftc8inx 13063 3 weight weight NN cord-010092-uftc8inx 13063 4 was be VBD cord-010092-uftc8inx 13063 5 7.5 7.5 CD cord-010092-uftc8inx 13064 1 ( ( -LRB- cord-010092-uftc8inx 13064 2 Range range NN cord-010092-uftc8inx 13064 3 : : : cord-010092-uftc8inx 13064 4 2.77 2.77 CD cord-010092-uftc8inx 13064 5 - - SYM cord-010092-uftc8inx 13064 6 12.33 12.33 CD cord-010092-uftc8inx 13064 7 ) ) -RRB- cord-010092-uftc8inx 13064 8 . . . cord-010092-uftc8inx 13065 1 Our -PRON- PRP$ cord-010092-uftc8inx 13065 2 target target NN cord-010092-uftc8inx 13065 3 yield yield NN cord-010092-uftc8inx 13065 4 was be VBD cord-010092-uftc8inx 13065 5 ≥3 ≥3 NNP cord-010092-uftc8inx 13065 6 9 9 CD cord-010092-uftc8inx 13065 7 10 10 CD cord-010092-uftc8inx 13065 8 6 6 CD cord-010092-uftc8inx 13065 9 CD34 CD34 NNP cord-010092-uftc8inx 13065 10 + + CC cord-010092-uftc8inx 13066 1 cells cell NNS cord-010092-uftc8inx 13066 2 / / SYM cord-010092-uftc8inx 13066 3 kg kg NN cord-010092-uftc8inx 13066 4 body body NN cord-010092-uftc8inx 13066 5 weight weight NN cord-010092-uftc8inx 13066 6 of of IN cord-010092-uftc8inx 13066 7 the the DT cord-010092-uftc8inx 13066 8 recipient recipient NN cord-010092-uftc8inx 13066 9 and and CC cord-010092-uftc8inx 13066 10 in in IN cord-010092-uftc8inx 13066 11 only only RB cord-010092-uftc8inx 13066 12 2/34 2/34 CD cord-010092-uftc8inx 13066 13 ( ( -LRB- cord-010092-uftc8inx 13066 14 6 6 CD cord-010092-uftc8inx 13066 15 % % NN cord-010092-uftc8inx 13066 16 ) ) -RRB- cord-010092-uftc8inx 13066 17 cases case NNS cord-010092-uftc8inx 13067 1 , , , cord-010092-uftc8inx 13067 2 the the DT cord-010092-uftc8inx 13067 3 yield yield NN cord-010092-uftc8inx 13067 4 was be VBD cord-010092-uftc8inx 13067 5 <3 <3 NNS cord-010092-uftc8inx 13067 6 . . . cord-010092-uftc8inx 13068 1 18/34 18/34 CD cord-010092-uftc8inx 13068 2 ( ( -LRB- cord-010092-uftc8inx 13068 3 52.9 52.9 CD cord-010092-uftc8inx 13068 4 % % NN cord-010092-uftc8inx 13068 5 ) ) -RRB- cord-010092-uftc8inx 13068 6 procedures procedure NNS cord-010092-uftc8inx 13068 7 were be VBD cord-010092-uftc8inx 13068 8 LVL LVL NNP cord-010092-uftc8inx 13068 9 and and CC cord-010092-uftc8inx 13068 10 16/34 16/34 CD cord-010092-uftc8inx 13068 11 ( ( -LRB- cord-010092-uftc8inx 13068 12 47.1 47.1 CD cord-010092-uftc8inx 13068 13 % % NN cord-010092-uftc8inx 13068 14 ) ) -RRB- cord-010092-uftc8inx 13068 15 were be VBD cord-010092-uftc8inx 13068 16 SVL SVL NNP cord-010092-uftc8inx 13068 17 . . . cord-010092-uftc8inx 13069 1 Summary Summary NNP cord-010092-uftc8inx 13069 2 / / SYM cord-010092-uftc8inx 13069 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 13069 4 : : : cord-010092-uftc8inx 13070 1 Most Most JJS cord-010092-uftc8inx 13070 2 of of IN cord-010092-uftc8inx 13070 3 our -PRON- PRP$ cord-010092-uftc8inx 13070 4 PBSC PBSC NNP cord-010092-uftc8inx 13070 5 were be VBD cord-010092-uftc8inx 13070 6 done do VBN cord-010092-uftc8inx 13070 7 for for IN cord-010092-uftc8inx 13070 8 haematological haematological JJ cord-010092-uftc8inx 13070 9 indications indication NNS cord-010092-uftc8inx 13070 10 ( ( -LRB- cord-010092-uftc8inx 13070 11 85.3 85.3 CD cord-010092-uftc8inx 13070 12 % % NN cord-010092-uftc8inx 13070 13 ) ) -RRB- cord-010092-uftc8inx 13070 14 and and CC cord-010092-uftc8inx 13070 15 the the DT cord-010092-uftc8inx 13070 16 target target NN cord-010092-uftc8inx 13070 17 dose dose NN cord-010092-uftc8inx 13070 18 was be VBD cord-010092-uftc8inx 13070 19 3 3 CD cord-010092-uftc8inx 13070 20 9 9 CD cord-010092-uftc8inx 13070 21 10 10 CD cord-010092-uftc8inx 13070 22 6 6 CD cord-010092-uftc8inx 13070 23 cells cell NNS cord-010092-uftc8inx 13070 24 / / SYM cord-010092-uftc8inx 13070 25 ll ll VBP cord-010092-uftc8inx 13070 26 in in IN cord-010092-uftc8inx 13070 27 single single JJ cord-010092-uftc8inx 13070 28 leukapheresis leukapheresis NN cord-010092-uftc8inx 13070 29 . . . cord-010092-uftc8inx 13071 1 In in IN cord-010092-uftc8inx 13071 2 32 32 CD cord-010092-uftc8inx 13071 3 cases case NNS cord-010092-uftc8inx 13071 4 ( ( -LRB- cord-010092-uftc8inx 13071 5 94 94 CD cord-010092-uftc8inx 13071 6 % % NN cord-010092-uftc8inx 13071 7 ) ) -RRB- cord-010092-uftc8inx 13071 8 , , , cord-010092-uftc8inx 13071 9 target target NN cord-010092-uftc8inx 13071 10 yield yield NN cord-010092-uftc8inx 13071 11 was be VBD cord-010092-uftc8inx 13071 12 achieved achieve VBN cord-010092-uftc8inx 13071 13 , , , cord-010092-uftc8inx 13071 14 only only RB cord-010092-uftc8inx 13071 15 2 2 CD cord-010092-uftc8inx 13071 16 cases case NNS cord-010092-uftc8inx 13071 17 had have VBD cord-010092-uftc8inx 13071 18 <3 <3 . cord-010092-uftc8inx 13072 1 but but CC cord-010092-uftc8inx 13072 2 > > XX cord-010092-uftc8inx 13073 1 2 2 CD cord-010092-uftc8inx 13073 2 yield yield NN cord-010092-uftc8inx 13073 3 . . . cord-010092-uftc8inx 13074 1 In in IN cord-010092-uftc8inx 13074 2 our -PRON- PRP$ cord-010092-uftc8inx 13074 3 study study NN cord-010092-uftc8inx 13074 4 donors donor NNS cord-010092-uftc8inx 13074 5 < < XX cord-010092-uftc8inx 13074 6 5 5 CD cord-010092-uftc8inx 13074 7 years year NNS cord-010092-uftc8inx 13074 8 have have VBP cord-010092-uftc8inx 13074 9 shown show VBN cord-010092-uftc8inx 13074 10 to to TO cord-010092-uftc8inx 13074 11 mobilize mobilize VB cord-010092-uftc8inx 13074 12 better well RBR cord-010092-uftc8inx 13074 13 than than IN cord-010092-uftc8inx 13074 14 the the DT cord-010092-uftc8inx 13074 15 older old JJR cord-010092-uftc8inx 13074 16 children child NNS cord-010092-uftc8inx 13074 17 . . . cord-010092-uftc8inx 13075 1 Hematocrit hematocrit NN cord-010092-uftc8inx 13075 2 ( ( -LRB- cord-010092-uftc8inx 13075 3 Hct Hct NNP cord-010092-uftc8inx 13075 4 ) ) -RRB- cord-010092-uftc8inx 13075 5 and and CC cord-010092-uftc8inx 13075 6 weight weight NN cord-010092-uftc8inx 13075 7 showed show VBD cord-010092-uftc8inx 13075 8 correlation correlation NN cord-010092-uftc8inx 13075 9 with with IN cord-010092-uftc8inx 13075 10 CD34 CD34 NNP cord-010092-uftc8inx 13075 11 + + CC cord-010092-uftc8inx 13075 12 cell cell NN cord-010092-uftc8inx 13075 13 yield yield NN cord-010092-uftc8inx 13075 14 but but CC cord-010092-uftc8inx 13075 15 they -PRON- PRP cord-010092-uftc8inx 13075 16 can can MD cord-010092-uftc8inx 13075 17 not not RB cord-010092-uftc8inx 13075 18 be be VB cord-010092-uftc8inx 13075 19 taken take VBN cord-010092-uftc8inx 13075 20 absolute absolute JJ cord-010092-uftc8inx 13075 21 predictors predictor NNS cord-010092-uftc8inx 13075 22 . . . cord-010092-uftc8inx 13076 1 WBC WBC NNP cord-010092-uftc8inx 13076 2 count count NN cord-010092-uftc8inx 13076 3 can can MD cord-010092-uftc8inx 13076 4 not not RB cord-010092-uftc8inx 13076 5 be be VB cord-010092-uftc8inx 13076 6 taken take VBN cord-010092-uftc8inx 13076 7 as as IN cord-010092-uftc8inx 13076 8 a a DT cord-010092-uftc8inx 13076 9 predictor predictor NN cord-010092-uftc8inx 13076 10 for for IN cord-010092-uftc8inx 13076 11 CD34 CD34 NNP cord-010092-uftc8inx 13076 12 yield yield NN cord-010092-uftc8inx 13076 13 as as IN cord-010092-uftc8inx 13076 14 high high JJ cord-010092-uftc8inx 13076 15 WBC WBC NNP cord-010092-uftc8inx 13076 16 count count NN cord-010092-uftc8inx 13076 17 did do VBD cord-010092-uftc8inx 13076 18 not not RB cord-010092-uftc8inx 13076 19 convert convert VB cord-010092-uftc8inx 13076 20 into into IN cord-010092-uftc8inx 13076 21 high high JJ cord-010092-uftc8inx 13076 22 CD34 CD34 NNP cord-010092-uftc8inx 13076 23 yield yield NN cord-010092-uftc8inx 13076 24 or or CC cord-010092-uftc8inx 13076 25 vice vice NN cord-010092-uftc8inx 13076 26 versa versa RB cord-010092-uftc8inx 13076 27 . . . cord-010092-uftc8inx 13077 1 High high JJ cord-010092-uftc8inx 13077 2 prepheresis prepheresis NN cord-010092-uftc8inx 13077 3 CD34 CD34 NNP cord-010092-uftc8inx 13077 4 + + CC cord-010092-uftc8inx 13077 5 count count NN cord-010092-uftc8inx 13077 6 gave give VBD cord-010092-uftc8inx 13077 7 higher high JJR cord-010092-uftc8inx 13077 8 postpheresis postpheresis NN cord-010092-uftc8inx 13077 9 CD34 CD34 NNP cord-010092-uftc8inx 13077 10 + + CC cord-010092-uftc8inx 13077 11 count count NN cord-010092-uftc8inx 13077 12 . . . cord-010092-uftc8inx 13078 1 Large large JJ cord-010092-uftc8inx 13078 2 volume volume NN cord-010092-uftc8inx 13078 3 leukapheresis leukapheresis NN cord-010092-uftc8inx 13078 4 ( ( -LRB- cord-010092-uftc8inx 13078 5 LVL LVL NNP cord-010092-uftc8inx 13078 6 ) ) -RRB- cord-010092-uftc8inx 13078 7 , , , cord-010092-uftc8inx 13078 8 > > XX cord-010092-uftc8inx 13079 1 3 3 CD cord-010092-uftc8inx 13079 2 TBV TBV NNP cord-010092-uftc8inx 13079 3 gave give VBD cord-010092-uftc8inx 13079 4 higher high JJR cord-010092-uftc8inx 13079 5 yield yield NN cord-010092-uftc8inx 13079 6 as as IN cord-010092-uftc8inx 13079 7 compared compare VBN cord-010092-uftc8inx 13079 8 to to IN cord-010092-uftc8inx 13079 9 Standard standard JJ cord-010092-uftc8inx 13079 10 volume volume NN cord-010092-uftc8inx 13079 11 leukapheresis leukapheresis NN cord-010092-uftc8inx 13079 12 ( ( -LRB- cord-010092-uftc8inx 13079 13 SVL SVL NNP cord-010092-uftc8inx 13079 14 ) ) -RRB- cord-010092-uftc8inx 13079 15 . . . cord-010092-uftc8inx 13080 1 Blood blood NN cord-010092-uftc8inx 13080 2 volume volume NN cord-010092-uftc8inx 13080 3 processed process VBN cord-010092-uftc8inx 13080 4 related relate VBN cord-010092-uftc8inx 13080 5 to to IN cord-010092-uftc8inx 13080 6 prepheresis prepheresis NN cord-010092-uftc8inx 13080 7 CD34 CD34 NNP cord-010092-uftc8inx 13081 1 + + CC cord-010092-uftc8inx 13081 2 count count NN cord-010092-uftc8inx 13082 1 and/or and/or CC cord-010092-uftc8inx 13082 2 the the DT cord-010092-uftc8inx 13082 3 weight weight NN cord-010092-uftc8inx 13082 4 difference difference NN cord-010092-uftc8inx 13082 5 between between IN cord-010092-uftc8inx 13082 6 the the DT cord-010092-uftc8inx 13082 7 donor donor NN cord-010092-uftc8inx 13082 8 and and CC cord-010092-uftc8inx 13082 9 recipient recipient NN cord-010092-uftc8inx 13082 10 . . . cord-010092-uftc8inx 13083 1 Other other JJ cord-010092-uftc8inx 13083 2 parameters parameter NNS cord-010092-uftc8inx 13083 3 like like IN cord-010092-uftc8inx 13083 4 hematocrit hematocrit NN cord-010092-uftc8inx 13083 5 , , , cord-010092-uftc8inx 13083 6 WBC WBC NNP cord-010092-uftc8inx 13083 7 count count NN cord-010092-uftc8inx 13083 8 , , , cord-010092-uftc8inx 13083 9 age age NN cord-010092-uftc8inx 13083 10 etc etc FW cord-010092-uftc8inx 13083 11 did do VBD cord-010092-uftc8inx 13083 12 not not RB cord-010092-uftc8inx 13083 13 show show VB cord-010092-uftc8inx 13083 14 correlation correlation NN cord-010092-uftc8inx 13083 15 to to IN cord-010092-uftc8inx 13083 16 the the DT cord-010092-uftc8inx 13083 17 volume volume NN cord-010092-uftc8inx 13083 18 processed process VBN cord-010092-uftc8inx 13083 19 . . . cord-010092-uftc8inx 13084 1 In in IN cord-010092-uftc8inx 13084 2 our -PRON- PRP$ cord-010092-uftc8inx 13084 3 study study NN cord-010092-uftc8inx 13084 4 , , , cord-010092-uftc8inx 13084 5 younger young JJR cord-010092-uftc8inx 13084 6 age age NN cord-010092-uftc8inx 13084 7 and and CC cord-010092-uftc8inx 13084 8 prepheresis prepheresis NN cord-010092-uftc8inx 13084 9 CD34 CD34 NNP cord-010092-uftc8inx 13085 1 + + CC cord-010092-uftc8inx 13085 2 count count NN cord-010092-uftc8inx 13085 3 were be VBD cord-010092-uftc8inx 13085 4 found find VBN cord-010092-uftc8inx 13085 5 as as IN cord-010092-uftc8inx 13085 6 the the DT cord-010092-uftc8inx 13085 7 most most RBS cord-010092-uftc8inx 13085 8 relevant relevant JJ cord-010092-uftc8inx 13085 9 predictors predictor NNS cord-010092-uftc8inx 13085 10 for for IN cord-010092-uftc8inx 13085 11 stem stem NN cord-010092-uftc8inx 13085 12 cell cell NN cord-010092-uftc8inx 13085 13 yield yield NN cord-010092-uftc8inx 13085 14 . . . cord-010092-uftc8inx 13086 1 Background background NN cord-010092-uftc8inx 13086 2 : : : cord-010092-uftc8inx 13087 1 Allogeneic allogeneic IN cord-010092-uftc8inx 13087 2 hematopoietic hematopoietic JJ cord-010092-uftc8inx 13087 3 stem stem NN cord-010092-uftc8inx 13087 4 cell cell NN cord-010092-uftc8inx 13087 5 transplantation transplantation NN cord-010092-uftc8inx 13087 6 is be VBZ cord-010092-uftc8inx 13087 7 an an DT cord-010092-uftc8inx 13087 8 established establish VBN cord-010092-uftc8inx 13087 9 therapy therapy NN cord-010092-uftc8inx 13087 10 for for IN cord-010092-uftc8inx 13087 11 many many JJ cord-010092-uftc8inx 13087 12 hematologic hematologic JJ cord-010092-uftc8inx 13087 13 disorders disorder NNS cord-010092-uftc8inx 13087 14 . . . cord-010092-uftc8inx 13088 1 Since since IN cord-010092-uftc8inx 13088 2 the the DT cord-010092-uftc8inx 13088 3 discoveries discovery NNS cord-010092-uftc8inx 13088 4 of of IN cord-010092-uftc8inx 13088 5 the the DT cord-010092-uftc8inx 13088 6 potential potential NN cord-010092-uftc8inx 13088 7 of of IN cord-010092-uftc8inx 13088 8 Peripheral Peripheral NNP cord-010092-uftc8inx 13088 9 Blood Blood NNP cord-010092-uftc8inx 13088 10 Stem Stem NNP cord-010092-uftc8inx 13088 11 Cells cell NNS cord-010092-uftc8inx 13088 12 ( ( -LRB- cord-010092-uftc8inx 13088 13 PBSC PBSC NNP cord-010092-uftc8inx 13088 14 ) ) -RRB- cord-010092-uftc8inx 13088 15 in in IN cord-010092-uftc8inx 13088 16 the the DT cord-010092-uftc8inx 13088 17 hematopoietic hematopoietic JJ cord-010092-uftc8inx 13088 18 reconstitution reconstitution NN cord-010092-uftc8inx 13088 19 mid mid NN cord-010092-uftc8inx 13088 20 1980s 1980 NNS cord-010092-uftc8inx 13088 21 and and CC cord-010092-uftc8inx 13088 22 early early JJ cord-010092-uftc8inx 13088 23 1990s 1990 NNS cord-010092-uftc8inx 13088 24 PBSC PBSC NNP cord-010092-uftc8inx 13088 25 gradually gradually RB cord-010092-uftc8inx 13088 26 replaced replace VBD cord-010092-uftc8inx 13088 27 bone bone NN cord-010092-uftc8inx 13088 28 marrow marrow NN cord-010092-uftc8inx 13088 29 as as IN cord-010092-uftc8inx 13088 30 the the DT cord-010092-uftc8inx 13088 31 preferred preferred JJ cord-010092-uftc8inx 13088 32 source source NN cord-010092-uftc8inx 13088 33 of of IN cord-010092-uftc8inx 13088 34 stem stem NN cord-010092-uftc8inx 13088 35 cells cell NNS cord-010092-uftc8inx 13088 36 . . . cord-010092-uftc8inx 13089 1 The the DT cord-010092-uftc8inx 13089 2 introduction introduction NN cord-010092-uftc8inx 13089 3 of of IN cord-010092-uftc8inx 13089 4 hematopoietic hematopoietic JJ cord-010092-uftc8inx 13089 5 cytokines cytokine NNS cord-010092-uftc8inx 13089 6 that that WDT cord-010092-uftc8inx 13089 7 can can MD cord-010092-uftc8inx 13089 8 mobilize mobilize VB cord-010092-uftc8inx 13089 9 large large JJ cord-010092-uftc8inx 13089 10 number number NN cord-010092-uftc8inx 13089 11 of of IN cord-010092-uftc8inx 13089 12 progenitors progenitor NNS cord-010092-uftc8inx 13089 13 into into IN cord-010092-uftc8inx 13089 14 circulation circulation NN cord-010092-uftc8inx 13089 15 accelerated accelerate VBD cord-010092-uftc8inx 13089 16 PBSC PBSC NNP cord-010092-uftc8inx 13089 17 usage usage NN cord-010092-uftc8inx 13089 18 . . . cord-010092-uftc8inx 13090 1 Aims aim VBZ cord-010092-uftc8inx 13090 2 : : : cord-010092-uftc8inx 13091 1 The the DT cord-010092-uftc8inx 13091 2 aim aim NN cord-010092-uftc8inx 13091 3 of of IN cord-010092-uftc8inx 13091 4 our -PRON- PRP$ cord-010092-uftc8inx 13091 5 study study NN cord-010092-uftc8inx 13091 6 is be VBZ cord-010092-uftc8inx 13091 7 to to TO cord-010092-uftc8inx 13091 8 present present VB cord-010092-uftc8inx 13091 9 our -PRON- PRP$ cord-010092-uftc8inx 13091 10 18 18 CD cord-010092-uftc8inx 13091 11 year year NN cord-010092-uftc8inx 13091 12 experience experience NN cord-010092-uftc8inx 13091 13 with with IN cord-010092-uftc8inx 13091 14 apheresis apheresis NN cord-010092-uftc8inx 13091 15 collecting collecting NN cord-010092-uftc8inx 13091 16 of of IN cord-010092-uftc8inx 13091 17 PBSC PBSC NNP cord-010092-uftc8inx 13091 18 in in IN cord-010092-uftc8inx 13091 19 donors donor NNS cord-010092-uftc8inx 13091 20 . . . cord-010092-uftc8inx 13092 1 Methods method NNS cord-010092-uftc8inx 13092 2 : : : cord-010092-uftc8inx 13092 3 This this DT cord-010092-uftc8inx 13092 4 is be VBZ cord-010092-uftc8inx 13092 5 a a DT cord-010092-uftc8inx 13092 6 retrospective retrospective JJ cord-010092-uftc8inx 13092 7 study study NN cord-010092-uftc8inx 13092 8 performed perform VBN cord-010092-uftc8inx 13092 9 in in IN cord-010092-uftc8inx 13092 10 the the DT cord-010092-uftc8inx 13092 11 Institute Institute NNP cord-010092-uftc8inx 13092 12 for for IN cord-010092-uftc8inx 13092 13 Transfusion Transfusion NNP cord-010092-uftc8inx 13092 14 Medicine Medicine NNP cord-010092-uftc8inx 13092 15 of of IN cord-010092-uftc8inx 13092 16 Republic Republic NNP cord-010092-uftc8inx 13092 17 of of IN cord-010092-uftc8inx 13092 18 Macedonia Macedonia NNP cord-010092-uftc8inx 13092 19 and and CC cord-010092-uftc8inx 13092 20 University University NNP cord-010092-uftc8inx 13092 21 Hematology Hematology NNP cord-010092-uftc8inx 13092 22 Hospital Hospital NNP cord-010092-uftc8inx 13092 23 for for IN cord-010092-uftc8inx 13092 24 period period NN cord-010092-uftc8inx 13092 25 Background background NN cord-010092-uftc8inx 13092 26 : : : cord-010092-uftc8inx 13093 1 Obtaining obtain VBG cord-010092-uftc8inx 13093 2 unambiguous unambiguous JJ cord-010092-uftc8inx 13093 3 results result NNS cord-010092-uftc8inx 13093 4 of of IN cord-010092-uftc8inx 13093 5 HLA HLA NNP cord-010092-uftc8inx 13093 6 typing typing NN cord-010092-uftc8inx 13093 7 plays play VBZ cord-010092-uftc8inx 13093 8 an an DT cord-010092-uftc8inx 13093 9 important important JJ cord-010092-uftc8inx 13093 10 role role NN cord-010092-uftc8inx 13093 11 in in IN cord-010092-uftc8inx 13093 12 the the DT cord-010092-uftc8inx 13093 13 transplantation transplantation NN cord-010092-uftc8inx 13093 14 of of IN cord-010092-uftc8inx 13093 15 hematopoietic hematopoietic JJ cord-010092-uftc8inx 13093 16 stem stem NN cord-010092-uftc8inx 13093 17 cells cell NNS cord-010092-uftc8inx 13093 18 . . . cord-010092-uftc8inx 13094 1 Appropriate appropriate JJ cord-010092-uftc8inx 13094 2 selection selection NN cord-010092-uftc8inx 13094 3 of of IN cord-010092-uftc8inx 13094 4 alleles allele NNS cord-010092-uftc8inx 13094 5 in in IN cord-010092-uftc8inx 13094 6 the the DT cord-010092-uftc8inx 13094 7 level level NN cord-010092-uftc8inx 13094 8 of of IN cord-010092-uftc8inx 13094 9 HLA HLA NNP cord-010092-uftc8inx 13094 10 between between IN cord-010092-uftc8inx 13094 11 recipients recipient NNS cord-010092-uftc8inx 13094 12 and and CC cord-010092-uftc8inx 13094 13 unrelated unrelated JJ cord-010092-uftc8inx 13094 14 bone bone NN cord-010092-uftc8inx 13094 15 marrow marrow NN cord-010092-uftc8inx 13094 16 donors donor NNS cord-010092-uftc8inx 13094 17 reduces reduce VBZ cord-010092-uftc8inx 13094 18 the the DT cord-010092-uftc8inx 13094 19 risk risk NN cord-010092-uftc8inx 13094 20 of of IN cord-010092-uftc8inx 13094 21 transplant transplant NN cord-010092-uftc8inx 13094 22 rejection rejection NN cord-010092-uftc8inx 13094 23 and and CC cord-010092-uftc8inx 13094 24 graft graft NN cord-010092-uftc8inx 13094 25 - - HYPH cord-010092-uftc8inx 13094 26 versus versus IN cord-010092-uftc8inx 13094 27 - - HYPH cord-010092-uftc8inx 13094 28 host host NN cord-010092-uftc8inx 13094 29 disease disease NN cord-010092-uftc8inx 13094 30 . . . cord-010092-uftc8inx 13095 1 New new JJ cord-010092-uftc8inx 13095 2 generation generation NN cord-010092-uftc8inx 13095 3 technology technology NN cord-010092-uftc8inx 13095 4 ensures ensure VBZ cord-010092-uftc8inx 13095 5 the the DT cord-010092-uftc8inx 13095 6 highest high JJS cord-010092-uftc8inx 13095 7 possible possible JJ cord-010092-uftc8inx 13095 8 resolution resolution NN cord-010092-uftc8inx 13095 9 and and CC cord-010092-uftc8inx 13095 10 obtaining obtain VBG cord-010092-uftc8inx 13095 11 unambiguous unambiguous JJ cord-010092-uftc8inx 13095 12 genotyping genotyping NN cord-010092-uftc8inx 13095 13 results result NNS cord-010092-uftc8inx 13095 14 due due JJ cord-010092-uftc8inx 13095 15 to to IN cord-010092-uftc8inx 13095 16 the the DT cord-010092-uftc8inx 13095 17 high high JJ cord-010092-uftc8inx 13095 18 complexity complexity NN cord-010092-uftc8inx 13095 19 of of IN cord-010092-uftc8inx 13095 20 the the DT cord-010092-uftc8inx 13095 21 HLA HLA NNP cord-010092-uftc8inx 13095 22 system system NN cord-010092-uftc8inx 13095 23 . . . cord-010092-uftc8inx 13096 1 Currently currently RB cord-010092-uftc8inx 13096 2 , , , cord-010092-uftc8inx 13096 3 this this DT cord-010092-uftc8inx 13096 4 is be VBZ cord-010092-uftc8inx 13096 5 the the DT cord-010092-uftc8inx 13096 6 selection selection NN cord-010092-uftc8inx 13096 7 method method NN cord-010092-uftc8inx 13096 8 for for IN cord-010092-uftc8inx 13096 9 obtaining obtain VBG cord-010092-uftc8inx 13096 10 HLA HLA NNP cord-010092-uftc8inx 13096 11 test test NN cord-010092-uftc8inx 13096 12 results result NNS cord-010092-uftc8inx 13096 13 at at IN cord-010092-uftc8inx 13096 14 the the DT cord-010092-uftc8inx 13096 15 high high JJ cord-010092-uftc8inx 13096 16 resolution resolution NN cord-010092-uftc8inx 13096 17 level level NN cord-010092-uftc8inx 13096 18 . . . cord-010092-uftc8inx 13097 1 Aims aim VBZ cord-010092-uftc8inx 13097 2 : : : cord-010092-uftc8inx 13098 1 The the DT cord-010092-uftc8inx 13098 2 aim aim NN cord-010092-uftc8inx 13098 3 of of IN cord-010092-uftc8inx 13098 4 this this DT cord-010092-uftc8inx 13098 5 study study NN cord-010092-uftc8inx 13098 6 was be VBD cord-010092-uftc8inx 13098 7 to to TO cord-010092-uftc8inx 13098 8 determine determine VB cord-010092-uftc8inx 13098 9 11 11 CD cord-010092-uftc8inx 13098 10 HLA HLA NNP cord-010092-uftc8inx 13098 11 loci locus NNS cord-010092-uftc8inx 13098 12 ( ( -LRB- cord-010092-uftc8inx 13098 13 HLA HLA NNP cord-010092-uftc8inx 13098 14 - - HYPH cord-010092-uftc8inx 13098 15 A A NNP cord-010092-uftc8inx 13098 16 , , , cord-010092-uftc8inx 13098 17 -B -b ADD cord-010092-uftc8inx 13098 18 , , , cord-010092-uftc8inx 13098 19 -C -C NNS cord-010092-uftc8inx 13098 20 , , , cord-010092-uftc8inx 13098 21 DRB1/3/ DRB1/3/ NNP cord-010092-uftc8inx 13098 22 4/5 4/5 CD cord-010092-uftc8inx 13098 23 , , , cord-010092-uftc8inx 13098 24 DQB1 DQB1 NNP cord-010092-uftc8inx 13098 25 , , , cord-010092-uftc8inx 13098 26 DPB1 DPB1 NNP cord-010092-uftc8inx 13098 27 , , , cord-010092-uftc8inx 13098 28 DPA1 DPA1 NNP cord-010092-uftc8inx 13098 29 , , , cord-010092-uftc8inx 13098 30 DQA1 DQA1 NNPS cord-010092-uftc8inx 13098 31 ) ) -RRB- cord-010092-uftc8inx 13098 32 in in IN cord-010092-uftc8inx 13098 33 potential potential JJ cord-010092-uftc8inx 13098 34 bone bone NN cord-010092-uftc8inx 13098 35 marrow marrow NN cord-010092-uftc8inx 13098 36 donors donor NNS cord-010092-uftc8inx 13098 37 from from IN cord-010092-uftc8inx 13098 38 Poland Poland NNP cord-010092-uftc8inx 13098 39 . . . cord-010092-uftc8inx 13099 1 The the DT cord-010092-uftc8inx 13099 2 research research NN cord-010092-uftc8inx 13099 3 included include VBD cord-010092-uftc8inx 13099 4 18,500 18,500 CD cord-010092-uftc8inx 13099 5 potential potential JJ cord-010092-uftc8inx 13099 6 bone bone NN cord-010092-uftc8inx 13099 7 marrow marrow NN cord-010092-uftc8inx 13099 8 donors donor NNS cord-010092-uftc8inx 13099 9 registered register VBN cord-010092-uftc8inx 13099 10 between between IN cord-010092-uftc8inx 13099 11 2017 2017 CD cord-010092-uftc8inx 13099 12 and and CC cord-010092-uftc8inx 13099 13 2018 2018 CD cord-010092-uftc8inx 13099 14 . . . cord-010092-uftc8inx 13100 1 A a DT cord-010092-uftc8inx 13100 2 novelty novelty NN cord-010092-uftc8inx 13100 3 of of IN cord-010092-uftc8inx 13100 4 this this DT cord-010092-uftc8inx 13100 5 paper paper NN cord-010092-uftc8inx 13100 6 was be VBD cord-010092-uftc8inx 13100 7 that that IN cord-010092-uftc8inx 13100 8 the the DT cord-010092-uftc8inx 13100 9 amplification amplification NN cord-010092-uftc8inx 13100 10 of of IN cord-010092-uftc8inx 13100 11 all all DT cord-010092-uftc8inx 13100 12 11 11 CD cord-010092-uftc8inx 13100 13 HLA HLA NNP cord-010092-uftc8inx 13100 14 loci locus NNS cord-010092-uftc8inx 13100 15 was be VBD cord-010092-uftc8inx 13100 16 performed perform VBN cord-010092-uftc8inx 13100 17 by by IN cord-010092-uftc8inx 13100 18 using use VBG cord-010092-uftc8inx 13100 19 multiplex multiplex JJ cord-010092-uftc8inx 13100 20 PCR PCR NNP cord-010092-uftc8inx 13100 21 primers primer NNS cord-010092-uftc8inx 13100 22 in in IN cord-010092-uftc8inx 13100 23 a a DT cord-010092-uftc8inx 13100 24 single single JJ cord-010092-uftc8inx 13100 25 tube tube NN cord-010092-uftc8inx 13100 26 . . . cord-010092-uftc8inx 13101 1 That that DT cord-010092-uftc8inx 13101 2 solution solution NN cord-010092-uftc8inx 13101 3 completely completely RB cord-010092-uftc8inx 13101 4 eliminated eliminate VBD cord-010092-uftc8inx 13101 5 the the DT cord-010092-uftc8inx 13101 6 need need NN cord-010092-uftc8inx 13101 7 to to TO cord-010092-uftc8inx 13101 8 pool pool VB cord-010092-uftc8inx 13101 9 amplicons amplicon NNS cord-010092-uftc8inx 13101 10 . . . cord-010092-uftc8inx 13102 1 Methods method NNS cord-010092-uftc8inx 13102 2 : : : cord-010092-uftc8inx 13103 1 The the DT cord-010092-uftc8inx 13103 2 typing typing NN cord-010092-uftc8inx 13103 3 of of IN cord-010092-uftc8inx 13103 4 the the DT cord-010092-uftc8inx 13103 5 11 11 CD cord-010092-uftc8inx 13103 6 HLA HLA NNP cord-010092-uftc8inx 13103 7 loci locus NNS cord-010092-uftc8inx 13103 8 ( ( -LRB- cord-010092-uftc8inx 13103 9 HLA HLA NNP cord-010092-uftc8inx 13103 10 - - HYPH cord-010092-uftc8inx 13103 11 A A NNP cord-010092-uftc8inx 13103 12 , , , cord-010092-uftc8inx 13103 13 -B -b ADD cord-010092-uftc8inx 13103 14 , , , cord-010092-uftc8inx 13103 15 -C -C NNS cord-010092-uftc8inx 13103 16 , , , cord-010092-uftc8inx 13103 17 DRB1/3/4/5 DRB1/3/4/5 NNP cord-010092-uftc8inx 13103 18 , , , cord-010092-uftc8inx 13103 19 DQB1 DQB1 NNP cord-010092-uftc8inx 13103 20 , , , cord-010092-uftc8inx 13103 21 DPB1 DPB1 NNP cord-010092-uftc8inx 13103 22 , , , cord-010092-uftc8inx 13103 23 DPA1 DPA1 NNP cord-010092-uftc8inx 13103 24 , , , cord-010092-uftc8inx 13103 25 DQA1 DQA1 NNPS cord-010092-uftc8inx 13103 26 ) ) -RRB- cord-010092-uftc8inx 13103 27 of of IN cord-010092-uftc8inx 13103 28 potential potential JJ cord-010092-uftc8inx 13103 29 bone bone NN cord-010092-uftc8inx 13103 30 marrow marrow NN cord-010092-uftc8inx 13103 31 donors donor NNS cord-010092-uftc8inx 13103 32 was be VBD cord-010092-uftc8inx 13103 33 made make VBN cord-010092-uftc8inx 13103 34 by by IN cord-010092-uftc8inx 13103 35 using use VBG cord-010092-uftc8inx 13103 36 the the DT cord-010092-uftc8inx 13103 37 AllType AllType NNP cord-010092-uftc8inx 13103 38 TM TM NNP cord-010092-uftc8inx 13103 39 NGS NGS NNP cord-010092-uftc8inx 13103 40 11-loci 11-loci CD cord-010092-uftc8inx 13103 41 Amplification Amplification NNP cord-010092-uftc8inx 13103 42 Kit kit NN cord-010092-uftc8inx 13103 43 ( ( -LRB- cord-010092-uftc8inx 13103 44 One one CD cord-010092-uftc8inx 13103 45 Lambda Lambda NNP cord-010092-uftc8inx 13103 46 ) ) -RRB- cord-010092-uftc8inx 13103 47 . . . cord-010092-uftc8inx 13104 1 Genomic genomic JJ cord-010092-uftc8inx 13104 2 DNA dna NN cord-010092-uftc8inx 13104 3 was be VBD cord-010092-uftc8inx 13104 4 isolated isolate VBN cord-010092-uftc8inx 13104 5 from from IN cord-010092-uftc8inx 13104 6 peripheral peripheral JJ cord-010092-uftc8inx 13104 7 blood blood NN cord-010092-uftc8inx 13104 8 of of IN cord-010092-uftc8inx 13104 9 18,500 18,500 CD cord-010092-uftc8inx 13104 10 donors donor NNS cord-010092-uftc8inx 13104 11 . . . cord-010092-uftc8inx 13105 1 HLA HLA NNP cord-010092-uftc8inx 13105 2 genotypes genotype NNS cord-010092-uftc8inx 13105 3 were be VBD cord-010092-uftc8inx 13105 4 determined determine VBN cord-010092-uftc8inx 13105 5 according accord VBG cord-010092-uftc8inx 13105 6 to to IN cord-010092-uftc8inx 13105 7 the the DT cord-010092-uftc8inx 13105 8 manufacturer manufacturer NN cord-010092-uftc8inx 13105 9 's 's POS cord-010092-uftc8inx 13105 10 protocol protocol NN cord-010092-uftc8inx 13105 11 on on IN cord-010092-uftc8inx 13105 12 the the DT cord-010092-uftc8inx 13105 13 MiSeq MiSeq NNP cord-010092-uftc8inx 13105 14 Illumina Illumina NNP cord-010092-uftc8inx 13105 15 platform platform NN cord-010092-uftc8inx 13105 16 . . . cord-010092-uftc8inx 13106 1 The the DT cord-010092-uftc8inx 13106 2 obtained obtain VBN cord-010092-uftc8inx 13106 3 sequencing sequencing NN cord-010092-uftc8inx 13106 4 data datum NNS cord-010092-uftc8inx 13106 5 was be VBD cord-010092-uftc8inx 13106 6 evaluated evaluate VBN cord-010092-uftc8inx 13106 7 by by IN cord-010092-uftc8inx 13106 8 using use VBG cord-010092-uftc8inx 13106 9 the the DT cord-010092-uftc8inx 13106 10 TypeStream TypeStream NNP cord-010092-uftc8inx 13106 11 TM TM NNP cord-010092-uftc8inx 13106 12 Visual visual JJ cord-010092-uftc8inx 13106 13 NGS NGS NNP cord-010092-uftc8inx 13106 14 Analysis Analysis NNP cord-010092-uftc8inx 13106 15 Software Software NNP cord-010092-uftc8inx 13106 16 . . . cord-010092-uftc8inx 13107 1 Results result NNS cord-010092-uftc8inx 13107 2 : : : cord-010092-uftc8inx 13108 1 The the DT cord-010092-uftc8inx 13108 2 NGS NGS NNP cord-010092-uftc8inx 13108 3 method method NN cord-010092-uftc8inx 13108 4 allowed allow VBN cord-010092-uftc8inx 13108 5 to to IN cord-010092-uftc8inx 13108 6 obtaining obtain VBG cord-010092-uftc8inx 13108 7 unambiguous unambiguous JJ cord-010092-uftc8inx 13108 8 results result NNS cord-010092-uftc8inx 13108 9 of of IN cord-010092-uftc8inx 13108 10 genotyping genotyping NN cord-010092-uftc8inx 13108 11 of of IN cord-010092-uftc8inx 13108 12 potential potential JJ cord-010092-uftc8inx 13108 13 bone bone NN cord-010092-uftc8inx 13108 14 marrow marrow NN cord-010092-uftc8inx 13108 15 donors donor NNS cord-010092-uftc8inx 13108 16 , , , cord-010092-uftc8inx 13108 17 and and CC cord-010092-uftc8inx 13108 18 also also RB cord-010092-uftc8inx 13108 19 provided provide VBD cord-010092-uftc8inx 13108 20 the the DT cord-010092-uftc8inx 13108 21 identification identification NN cord-010092-uftc8inx 13108 22 of of IN cord-010092-uftc8inx 13108 23 rare rare JJ cord-010092-uftc8inx 13108 24 alleles allele NNS cord-010092-uftc8inx 13108 25 , , , cord-010092-uftc8inx 13108 26 such such JJ cord-010092-uftc8inx 13108 27 as as IN cord-010092-uftc8inx 13108 28 : : : cord-010092-uftc8inx 13108 29 C*12 c*12 NN cord-010092-uftc8inx 13108 30 : : : cord-010092-uftc8inx 13108 31 143 143 CD cord-010092-uftc8inx 13108 32 , , , cord-010092-uftc8inx 13108 33 C*12 C*12 NNP cord-010092-uftc8inx 13108 34 : : : cord-010092-uftc8inx 13108 35 30 30 CD cord-010092-uftc8inx 13108 36 , , , cord-010092-uftc8inx 13108 37 C*05 C*05 NNP cord-010092-uftc8inx 13108 38 : : : cord-010092-uftc8inx 13108 39 37 37 CD cord-010092-uftc8inx 13108 40 , , , cord-010092-uftc8inx 13108 41 C*07 C*07 NNP cord-010092-uftc8inx 13108 42 : : : cord-010092-uftc8inx 13108 43 151 151 CD cord-010092-uftc8inx 13108 44 , , , cord-010092-uftc8inx 13108 45 DRB1 DRB1 NNP cord-010092-uftc8inx 13108 46 * * NFP cord-010092-uftc8inx 13108 47 11 11 CD cord-010092-uftc8inx 13108 48 : : : cord-010092-uftc8inx 13108 49 28 28 CD cord-010092-uftc8inx 13108 50 , , , cord-010092-uftc8inx 13108 51 C*14 C*14 NNP cord-010092-uftc8inx 13108 52 : : : cord-010092-uftc8inx 13108 53 04 04 CD cord-010092-uftc8inx 13108 54 , , , cord-010092-uftc8inx 13108 55 B*51 b*51 NN cord-010092-uftc8inx 13108 56 : : : cord-010092-uftc8inx 13108 57 22 22 CD cord-010092-uftc8inx 13108 58 , , , cord-010092-uftc8inx 13108 59 C*15 C*15 NNP cord-010092-uftc8inx 13108 60 : : : cord-010092-uftc8inx 13108 61 13 13 CD cord-010092-uftc8inx 13108 62 , , , cord-010092-uftc8inx 13108 63 DQB1 DQB1 NNP cord-010092-uftc8inx 13109 1 * * NFP cord-010092-uftc8inx 13109 2 03 03 CD cord-010092-uftc8inx 13109 3 : : : cord-010092-uftc8inx 13109 4 12 12 CD cord-010092-uftc8inx 13109 5 , , , cord-010092-uftc8inx 13109 6 DRB1 DRB1 NNP cord-010092-uftc8inx 13109 7 * * NFP cord-010092-uftc8inx 13109 8 14 14 CD cord-010092-uftc8inx 13109 9 : : : cord-010092-uftc8inx 13109 10 87 87 CD cord-010092-uftc8inx 13109 11 , , , cord-010092-uftc8inx 13109 12 DRB1 DRB1 NNP cord-010092-uftc8inx 13110 1 * * NFP cord-010092-uftc8inx 13110 2 11:69 11:69 CD cord-010092-uftc8inx 13110 3 . . . cord-010092-uftc8inx 13111 1 Summary Summary NNP cord-010092-uftc8inx 13111 2 / / SYM cord-010092-uftc8inx 13111 3 Conclusions Conclusions NNPS cord-010092-uftc8inx 13111 4 : : : cord-010092-uftc8inx 13111 5 1 1 CD cord-010092-uftc8inx 13111 6 . . . cord-010092-uftc8inx 13112 1 New new JJ cord-010092-uftc8inx 13112 2 generation generation NN cord-010092-uftc8inx 13112 3 sequencing sequencing NN cord-010092-uftc8inx 13112 4 technology technology NN cord-010092-uftc8inx 13112 5 ( ( -LRB- cord-010092-uftc8inx 13112 6 NGS NGS NNP cord-010092-uftc8inx 13112 7 ) ) -RRB- cord-010092-uftc8inx 13112 8 , , , cord-010092-uftc8inx 13112 9 which which WDT cord-010092-uftc8inx 13112 10 is be VBZ cord-010092-uftc8inx 13112 11 based base VBN cord-010092-uftc8inx 13112 12 on on IN cord-010092-uftc8inx 13112 13 PCR PCR NNP cord-010092-uftc8inx 13112 14 , , , cord-010092-uftc8inx 13112 15 ensures ensure VBZ cord-010092-uftc8inx 13112 16 the the DT cord-010092-uftc8inx 13112 17 highest high JJS cord-010092-uftc8inx 13112 18 possible possible JJ cord-010092-uftc8inx 13112 19 resolution resolution NN cord-010092-uftc8inx 13112 20 . . . cord-010092-uftc8inx 13113 1 2 2 LS cord-010092-uftc8inx 13113 2 . . . cord-010092-uftc8inx 13114 1 The the DT cord-010092-uftc8inx 13114 2 NGS NGS NNP cord-010092-uftc8inx 13114 3 method method NN cord-010092-uftc8inx 13114 4 allows allow VBZ cord-010092-uftc8inx 13114 5 to to TO cord-010092-uftc8inx 13114 6 obtain obtain VB cord-010092-uftc8inx 13114 7 more more RBR cord-010092-uftc8inx 13114 8 accurate accurate JJ cord-010092-uftc8inx 13114 9 sequencing sequencing NN cord-010092-uftc8inx 13114 10 results result NNS cord-010092-uftc8inx 13114 11 compared compare VBN cord-010092-uftc8inx 13114 12 to to IN cord-010092-uftc8inx 13114 13 the the DT cord-010092-uftc8inx 13114 14 conventional conventional JJ cord-010092-uftc8inx 13114 15 methods method NNS cord-010092-uftc8inx 13114 16 . . . cord-010092-uftc8inx 13115 1 3 3 LS cord-010092-uftc8inx 13115 2 . . . cord-010092-uftc8inx 13116 1 The the DT cord-010092-uftc8inx 13116 2 research research NN cord-010092-uftc8inx 13116 3 has have VBZ cord-010092-uftc8inx 13116 4 confirmed confirm VBN cord-010092-uftc8inx 13116 5 the the DT cord-010092-uftc8inx 13116 6 superiority superiority NN cord-010092-uftc8inx 13116 7 of of IN cord-010092-uftc8inx 13116 8 the the DT cord-010092-uftc8inx 13116 9 NGS NGS NNP cord-010092-uftc8inx 13116 10 method method NN cord-010092-uftc8inx 13116 11 over over IN cord-010092-uftc8inx 13116 12 conventional conventional JJ cord-010092-uftc8inx 13116 13 methods method NNS cord-010092-uftc8inx 13116 14 in in IN cord-010092-uftc8inx 13116 15 obtaining obtain VBG cord-010092-uftc8inx 13116 16 unambiguous unambiguous JJ cord-010092-uftc8inx 13116 17 HLA HLA NNP cord-010092-uftc8inx 13116 18 genotyping genotyping NN cord-010092-uftc8inx 13116 19 results result NNS cord-010092-uftc8inx 13116 20 at at IN cord-010092-uftc8inx 13116 21 the the DT cord-010092-uftc8inx 13116 22 high high JJ cord-010092-uftc8inx 13116 23 resolution resolution NN cord-010092-uftc8inx 13116 24 level level NN cord-010092-uftc8inx 13116 25 . . . cord-010092-uftc8inx 13117 1 Background background NN cord-010092-uftc8inx 13117 2 : : : cord-010092-uftc8inx 13118 1 The the DT cord-010092-uftc8inx 13118 2 accurate accurate JJ cord-010092-uftc8inx 13118 3 results result NNS cord-010092-uftc8inx 13118 4 of of IN cord-010092-uftc8inx 13118 5 HLA HLA NNP cord-010092-uftc8inx 13118 6 typing typing NN cord-010092-uftc8inx 13118 7 are be VBP cord-010092-uftc8inx 13118 8 significant significant JJ cord-010092-uftc8inx 13118 9 for for IN cord-010092-uftc8inx 13118 10 ensuring ensure VBG cord-010092-uftc8inx 13118 11 the the DT cord-010092-uftc8inx 13118 12 success success NN cord-010092-uftc8inx 13118 13 rate rate NN cord-010092-uftc8inx 13118 14 of of IN cord-010092-uftc8inx 13118 15 hematopoietic hematopoietic JJ cord-010092-uftc8inx 13118 16 stem stem NN cord-010092-uftc8inx 13118 17 cell cell NN cord-010092-uftc8inx 13118 18 transplantation transplantation NN cord-010092-uftc8inx 13118 19 . . . cord-010092-uftc8inx 13119 1 Currently currently RB cord-010092-uftc8inx 13119 2 , , , cord-010092-uftc8inx 13119 3 HLA HLA NNP cord-010092-uftc8inx 13119 4 typing typing NN cord-010092-uftc8inx 13119 5 is be VBZ cord-010092-uftc8inx 13119 6 mainly mainly RB cord-010092-uftc8inx 13119 7 based base VBN cord-010092-uftc8inx 13119 8 on on IN cord-010092-uftc8inx 13119 9 Sanger Sanger NNP cord-010092-uftc8inx 13119 10 sequencing sequencing NN cord-010092-uftc8inx 13119 11 , , , cord-010092-uftc8inx 13119 12 which which WDT cord-010092-uftc8inx 13119 13 has have VBZ cord-010092-uftc8inx 13119 14 a a DT cord-010092-uftc8inx 13119 15 high high JJ cord-010092-uftc8inx 13119 16 proportion proportion NN cord-010092-uftc8inx 13119 17 of of IN cord-010092-uftc8inx 13119 18 ambiguous ambiguous JJ cord-010092-uftc8inx 13119 19 combination combination NN cord-010092-uftc8inx 13119 20 results result NNS cord-010092-uftc8inx 13119 21 indicating indicate VBG cord-010092-uftc8inx 13119 22 potential potential JJ cord-010092-uftc8inx 13119 23 errors error NNS cord-010092-uftc8inx 13119 24 for for IN cord-010092-uftc8inx 13119 25 HLA HLA NNP cord-010092-uftc8inx 13119 26 typing typing NN cord-010092-uftc8inx 13119 27 . . . cord-010092-uftc8inx 13120 1 It -PRON- PRP cord-010092-uftc8inx 13120 2 is be VBZ cord-010092-uftc8inx 13120 3 necessary necessary JJ cord-010092-uftc8inx 13120 4 for for IN cord-010092-uftc8inx 13120 5 finding find VBG cord-010092-uftc8inx 13120 6 a a DT cord-010092-uftc8inx 13120 7 more more RBR cord-010092-uftc8inx 13120 8 accurate accurate JJ cord-010092-uftc8inx 13120 9 typing typing NN cord-010092-uftc8inx 13120 10 method method NN cord-010092-uftc8inx 13120 11 to to TO cord-010092-uftc8inx 13120 12 reduce reduce VB cord-010092-uftc8inx 13120 13 the the DT cord-010092-uftc8inx 13120 14 risk risk NN cord-010092-uftc8inx 13120 15 . . . cord-010092-uftc8inx 13121 1 Next next JJ cord-010092-uftc8inx 13121 2 - - HYPH cord-010092-uftc8inx 13121 3 generation generation NN cord-010092-uftc8inx 13121 4 sequencing sequencing NN cord-010092-uftc8inx 13121 5 ( ( -LRB- cord-010092-uftc8inx 13121 6 NGS NGS NNP cord-010092-uftc8inx 13121 7 ) ) -RRB- cord-010092-uftc8inx 13121 8 method method NN cord-010092-uftc8inx 13121 9 could could MD cord-010092-uftc8inx 13121 10 provide provide VB cord-010092-uftc8inx 13121 11 clonal clonal JJ cord-010092-uftc8inx 13121 12 sequencing sequencing NN cord-010092-uftc8inx 13121 13 of of IN cord-010092-uftc8inx 13121 14 single single JJ cord-010092-uftc8inx 13121 15 molecules molecule NNS cord-010092-uftc8inx 13121 16 , , , cord-010092-uftc8inx 13121 17 which which WDT cord-010092-uftc8inx 13121 18 has have VBZ cord-010092-uftc8inx 13121 19 been be VBN cord-010092-uftc8inx 13121 20 used use VBN cord-010092-uftc8inx 13121 21 for for IN cord-010092-uftc8inx 13121 22 HLA HLA NNP cord-010092-uftc8inx 13121 23 genotyping genotyping NN cord-010092-uftc8inx 13121 24 and and CC cord-010092-uftc8inx 13121 25 improved improve VBD cord-010092-uftc8inx 13121 26 the the DT cord-010092-uftc8inx 13121 27 scope scope NN cord-010092-uftc8inx 13121 28 and and CC cord-010092-uftc8inx 13121 29 precision precision NN cord-010092-uftc8inx 13121 30 of of IN cord-010092-uftc8inx 13121 31 HLA HLA NNP cord-010092-uftc8inx 13121 32 study study NN cord-010092-uftc8inx 13121 33 . . . cord-010092-uftc8inx 13122 1 Aims aim VBZ cord-010092-uftc8inx 13122 2 : : : cord-010092-uftc8inx 13123 1 To to TO cord-010092-uftc8inx 13123 2 establish establish VB cord-010092-uftc8inx 13123 3 a a DT cord-010092-uftc8inx 13123 4 full full JJ cord-010092-uftc8inx 13123 5 - - HYPH cord-010092-uftc8inx 13123 6 length length NN cord-010092-uftc8inx 13123 7 precision precision NN cord-010092-uftc8inx 13123 8 sequencing sequencing NN cord-010092-uftc8inx 13123 9 platform platform NN cord-010092-uftc8inx 13123 10 for for IN cord-010092-uftc8inx 13123 11 HLA HLA NNP cord-010092-uftc8inx 13123 12 - - HYPH cord-010092-uftc8inx 13123 13 I i NN cord-010092-uftc8inx 13123 14 gene gene NN cord-010092-uftc8inx 13123 15 ( ( -LRB- cord-010092-uftc8inx 13123 16 HLA HLA NNP cord-010092-uftc8inx 13123 17 - - HYPH cord-010092-uftc8inx 13123 18 A A NNP cord-010092-uftc8inx 13123 19 , , , cord-010092-uftc8inx 13123 20 -B -b ADD cord-010092-uftc8inx 13123 21 , , , cord-010092-uftc8inx 13123 22 -C -c ADD cord-010092-uftc8inx 13123 23 ) ) -RRB- cord-010092-uftc8inx 13123 24 based base VBN cord-010092-uftc8inx 13123 25 on on IN cord-010092-uftc8inx 13123 26 NGS NGS NNP cord-010092-uftc8inx 13123 27 technology technology NN cord-010092-uftc8inx 13123 28 and and CC cord-010092-uftc8inx 13123 29 be be VB cord-010092-uftc8inx 13123 30 evaluated evaluate VBN cord-010092-uftc8inx 13123 31 by by IN cord-010092-uftc8inx 13123 32 classical classical JJ cord-010092-uftc8inx 13123 33 Sangersequencing Sangersequencing NNP cord-010092-uftc8inx 13123 34 method method NN cord-010092-uftc8inx 13123 35 , , , cord-010092-uftc8inx 13123 36 which which WDT cord-010092-uftc8inx 13123 37 can can MD cord-010092-uftc8inx 13123 38 effectively effectively RB cord-010092-uftc8inx 13123 39 improve improve VB cord-010092-uftc8inx 13123 40 the the DT cord-010092-uftc8inx 13123 41 accuracy accuracy NN cord-010092-uftc8inx 13123 42 of of IN cord-010092-uftc8inx 13123 43 HLA HLA NNP cord-010092-uftc8inx 13123 44 typing type VBG cord-010092-uftc8inx 13123 45 for for IN cord-010092-uftc8inx 13123 46 donor donor NN cord-010092-uftc8inx 13123 47 and and CC cord-010092-uftc8inx 13123 48 recipient recipient NN cord-010092-uftc8inx 13123 49 in in IN cord-010092-uftc8inx 13123 50 hematopoietic hematopoietic JJ cord-010092-uftc8inx 13123 51 stem stem NN cord-010092-uftc8inx 13123 52 cell cell NN cord-010092-uftc8inx 13123 53 transplantation transplantation NN cord-010092-uftc8inx 13123 54 . . . cord-010092-uftc8inx 13124 1 Methods method NNS cord-010092-uftc8inx 13124 2 : : : cord-010092-uftc8inx 13124 3 HLA HLA NNP cord-010092-uftc8inx 13124 4 - - HYPH cord-010092-uftc8inx 13124 5 I I NNP cord-010092-uftc8inx 13124 6 ( ( -LRB- cord-010092-uftc8inx 13124 7 HLA HLA NNP cord-010092-uftc8inx 13124 8 - - HYPH cord-010092-uftc8inx 13124 9 A A NNP cord-010092-uftc8inx 13124 10 , , , cord-010092-uftc8inx 13124 11 -B -b ADD cord-010092-uftc8inx 13124 12 , , , cord-010092-uftc8inx 13124 13 -C -c ADD cord-010092-uftc8inx 13124 14 ) ) -RRB- cord-010092-uftc8inx 13125 1 gene gene NN cord-010092-uftc8inx 13125 2 - - HYPH cord-010092-uftc8inx 13125 3 specific specific JJ cord-010092-uftc8inx 13125 4 primers primer NNS cord-010092-uftc8inx 13125 5 were be VBD cord-010092-uftc8inx 13125 6 screened screen VBN cord-010092-uftc8inx 13125 7 , , , cord-010092-uftc8inx 13125 8 and and CC cord-010092-uftc8inx 13125 9 the the DT cord-010092-uftc8inx 13125 10 amplification amplification NN cord-010092-uftc8inx 13125 11 parameters parameter NNS cord-010092-uftc8inx 13125 12 were be VBD cord-010092-uftc8inx 13125 13 optimized optimize VBN cord-010092-uftc8inx 13125 14 to to TO cord-010092-uftc8inx 13125 15 obtain obtain VB cord-010092-uftc8inx 13125 16 full full JJ cord-010092-uftc8inx 13125 17 - - HYPH cord-010092-uftc8inx 13125 18 length length NN cord-010092-uftc8inx 13125 19 sequences sequence NNS cord-010092-uftc8inx 13125 20 of of IN cord-010092-uftc8inx 13125 21 HLA HLA NNP cord-010092-uftc8inx 13125 22 - - HYPH cord-010092-uftc8inx 13125 23 I i NN cord-010092-uftc8inx 13125 24 gene gene NN cord-010092-uftc8inx 13125 25 under under IN cord-010092-uftc8inx 13125 26 the the DT cord-010092-uftc8inx 13125 27 same same JJ cord-010092-uftc8inx 13125 28 condition condition NN cord-010092-uftc8inx 13125 29 . . . cord-010092-uftc8inx 13126 1 The the DT cord-010092-uftc8inx 13126 2 sample sample NN cord-010092-uftc8inx 13126 3 library library NN cord-010092-uftc8inx 13126 4 for for IN cord-010092-uftc8inx 13126 5 the the DT cord-010092-uftc8inx 13126 6 amplicon amplicon NN cord-010092-uftc8inx 13126 7 was be VBD cord-010092-uftc8inx 13126 8 prepared prepare VBN cord-010092-uftc8inx 13126 9 with with IN cord-010092-uftc8inx 13126 10 TransNGS TransNGS NNP cord-010092-uftc8inx 13126 11 Tn5 tn5 CD cord-010092-uftc8inx 13126 12 DNA DNA NNP cord-010092-uftc8inx 13126 13 library library NN cord-010092-uftc8inx 13126 14 Prep Prep NNP cord-010092-uftc8inx 13126 15 Kit Kit NNP cord-010092-uftc8inx 13126 16 and and CC cord-010092-uftc8inx 13126 17 the the DT cord-010092-uftc8inx 13126 18 sequencing sequencing NN cord-010092-uftc8inx 13126 19 step step NN cord-010092-uftc8inx 13126 20 was be VBD cord-010092-uftc8inx 13126 21 carried carry VBN cord-010092-uftc8inx 13126 22 out out RP cord-010092-uftc8inx 13126 23 with with IN cord-010092-uftc8inx 13126 24 Illumina Illumina NNP cord-010092-uftc8inx 13126 25 MiSeq MiSeq NNP cord-010092-uftc8inx 13126 26 platform platform NN cord-010092-uftc8inx 13126 27 according accord VBG cord-010092-uftc8inx 13126 28 to to IN cord-010092-uftc8inx 13126 29 the the DT cord-010092-uftc8inx 13126 30 manufacturer manufacturer NN cord-010092-uftc8inx 13126 31 ' ' POS cord-010092-uftc8inx 13126 32 protocol protocol NN cord-010092-uftc8inx 13126 33 . . . cord-010092-uftc8inx 13127 1 All all PDT cord-010092-uftc8inx 13127 2 the the DT cord-010092-uftc8inx 13127 3 sequencing sequencing NN cord-010092-uftc8inx 13127 4 data datum NNS cord-010092-uftc8inx 13127 5 in in IN cord-010092-uftc8inx 13127 6 FASTQ FASTQ NNP cord-010092-uftc8inx 13127 7 format format NN cord-010092-uftc8inx 13127 8 were be VBD cord-010092-uftc8inx 13127 9 analyzed analyze VBN cord-010092-uftc8inx 13127 10 by by IN cord-010092-uftc8inx 13127 11 TypeStream TypeStream NNP cord-010092-uftc8inx 13127 12 Visual Visual NNP cord-010092-uftc8inx 13127 13 Software Software NNP cord-010092-uftc8inx 13127 14 version version NN cord-010092-uftc8inx 13127 15 1.2.0(One 1.2.0(one CD cord-010092-uftc8inx 13127 16 Lambda lambda NN cord-010092-uftc8inx 13127 17 Inc.)with inc.)with XX cord-010092-uftc8inx 13127 18 the the DT cord-010092-uftc8inx 13127 19 default default NN cord-010092-uftc8inx 13127 20 setting setting NN cord-010092-uftc8inx 13127 21 . . . cord-010092-uftc8inx 13128 1 94 94 CD cord-010092-uftc8inx 13128 2 cord cord NN cord-010092-uftc8inx 13128 3 blood blood NN cord-010092-uftc8inx 13128 4 samples sample NNS cord-010092-uftc8inx 13128 5 were be VBD cord-010092-uftc8inx 13128 6 collected collect VBN cord-010092-uftc8inx 13128 7 for for IN cord-010092-uftc8inx 13128 8 HLA HLA NNP cord-010092-uftc8inx 13128 9 typing type VBG cord-010092-uftc8inx 13128 10 with with IN cord-010092-uftc8inx 13128 11 the the DT cord-010092-uftc8inx 13128 12 Mentioned mention VBN cord-010092-uftc8inx 13128 13 above above IN cord-010092-uftc8inx 13128 14 next next JJ cord-010092-uftc8inx 13128 15 - - HYPH cord-010092-uftc8inx 13128 16 generation generation NN cord-010092-uftc8inx 13128 17 sequencing sequencing NN cord-010092-uftc8inx 13128 18 method method NN cord-010092-uftc8inx 13128 19 in in IN cord-010092-uftc8inx 13128 20 our -PRON- PRP$ cord-010092-uftc8inx 13128 21 study study NN cord-010092-uftc8inx 13128 22 . . . cord-010092-uftc8inx 13129 1 In in IN cord-010092-uftc8inx 13129 2 parallel parallel NN cord-010092-uftc8inx 13129 3 , , , cord-010092-uftc8inx 13129 4 all all PDT cord-010092-uftc8inx 13129 5 the the DT cord-010092-uftc8inx 13129 6 sample sample NN cord-010092-uftc8inx 13129 7 were be VBD cord-010092-uftc8inx 13129 8 also also RB cord-010092-uftc8inx 13129 9 tested test VBN cord-010092-uftc8inx 13129 10 with with IN cord-010092-uftc8inx 13129 11 the the DT cord-010092-uftc8inx 13129 12 Sanger Sanger NNP cord-010092-uftc8inx 13129 13 sequencing sequencing NN cord-010092-uftc8inx 13129 14 method method NN cord-010092-uftc8inx 13129 15 according accord VBG cord-010092-uftc8inx 13129 16 to to IN cord-010092-uftc8inx 13129 17 the the DT cord-010092-uftc8inx 13129 18 previous previous JJ cord-010092-uftc8inx 13129 19 study study NN cord-010092-uftc8inx 13129 20 in in IN cord-010092-uftc8inx 13129 21 our -PRON- PRP$ cord-010092-uftc8inx 13129 22 laboratory laboratory NN cord-010092-uftc8inx 13129 23 . . . cord-010092-uftc8inx 13130 1 Results result NNS cord-010092-uftc8inx 13130 2 : : : cord-010092-uftc8inx 13131 1 94 94 CD cord-010092-uftc8inx 13131 2 samples sample NNS cord-010092-uftc8inx 13131 3 were be VBD cord-010092-uftc8inx 13131 4 successfully successfully RB cord-010092-uftc8inx 13131 5 tested test VBN cord-010092-uftc8inx 13131 6 with with IN cord-010092-uftc8inx 13131 7 two two CD cord-010092-uftc8inx 13131 8 methods method NNS cord-010092-uftc8inx 13131 9 and and CC cord-010092-uftc8inx 13131 10 the the DT cord-010092-uftc8inx 13131 11 coincidence coincidence NN cord-010092-uftc8inx 13131 12 rate rate NN cord-010092-uftc8inx 13131 13 between between IN cord-010092-uftc8inx 13131 14 two two CD cord-010092-uftc8inx 13131 15 sequencing sequencing NN cord-010092-uftc8inx 13131 16 methods method NNS cord-010092-uftc8inx 13131 17 was be VBD cord-010092-uftc8inx 13131 18 100 100 CD cord-010092-uftc8inx 13131 19 % % NN cord-010092-uftc8inx 13131 20 . . . cord-010092-uftc8inx 13132 1 With with IN cord-010092-uftc8inx 13132 2 the the DT cord-010092-uftc8inx 13132 3 next next JJ cord-010092-uftc8inx 13132 4 - - HYPH cord-010092-uftc8inx 13132 5 generation generation NN cord-010092-uftc8inx 13132 6 sequencing sequencing NN cord-010092-uftc8inx 13132 7 method method NN cord-010092-uftc8inx 13132 8 , , , cord-010092-uftc8inx 13132 9 the the DT cord-010092-uftc8inx 13132 10 probability probability NN cord-010092-uftc8inx 13132 11 of of IN cord-010092-uftc8inx 13132 12 ambiguous ambiguous JJ cord-010092-uftc8inx 13132 13 results result NNS cord-010092-uftc8inx 13132 14 among among IN cord-010092-uftc8inx 13132 15 94 94 CD cord-010092-uftc8inx 13132 16 samples sample NNS cord-010092-uftc8inx 13132 17 in in IN cord-010092-uftc8inx 13132 18 our -PRON- PRP$ cord-010092-uftc8inx 13132 19 study study NN cord-010092-uftc8inx 13132 20 is be VBZ cord-010092-uftc8inx 13132 21 1.06%(1/94 1.06%(1/94 CD cord-010092-uftc8inx 13132 22 ) ) -RRB- cord-010092-uftc8inx 13132 23 for for IN cord-010092-uftc8inx 13132 24 HLA HLA NNP cord-010092-uftc8inx 13132 25 - - HYPH cord-010092-uftc8inx 13132 26 A A NNP cord-010092-uftc8inx 13132 27 , , , cord-010092-uftc8inx 13132 28 5.31 5.31 CD cord-010092-uftc8inx 13132 29 % % NN cord-010092-uftc8inx 13132 30 ( ( -LRB- cord-010092-uftc8inx 13132 31 5/94 5/94 CD cord-010092-uftc8inx 13132 32 ) ) -RRB- cord-010092-uftc8inx 13132 33 for for IN cord-010092-uftc8inx 13132 34 HLA HLA NNP cord-010092-uftc8inx 13132 35 - - HYPH cord-010092-uftc8inx 13132 36 B B NNP cord-010092-uftc8inx 13132 37 and and CC cord-010092-uftc8inx 13132 38 0 0 CD cord-010092-uftc8inx 13132 39 % % NN cord-010092-uftc8inx 13132 40 ( ( -LRB- cord-010092-uftc8inx 13132 41 0/94)for 0/94)for IN cord-010092-uftc8inx 13132 42 HLA HLA NNP cord-010092-uftc8inx 13132 43 - - HYPH cord-010092-uftc8inx 13132 44 C. C. NNP cord-010092-uftc8inx 13133 1 However however RB cord-010092-uftc8inx 13133 2 , , , cord-010092-uftc8inx 13133 3 the the DT cord-010092-uftc8inx 13133 4 probability probability NN cord-010092-uftc8inx 13133 5 of of IN cord-010092-uftc8inx 13133 6 ambiguous ambiguous JJ cord-010092-uftc8inx 13133 7 results result NNS cord-010092-uftc8inx 13133 8 with with IN cord-010092-uftc8inx 13133 9 the the DT cord-010092-uftc8inx 13133 10 Sanger Sanger NNP cord-010092-uftc8inx 13133 11 sequencing sequencing NN cord-010092-uftc8inx 13133 12 method method NN cord-010092-uftc8inx 13133 13 is be VBZ cord-010092-uftc8inx 13133 14 96.8 96.8 CD cord-010092-uftc8inx 13133 15 % % NN cord-010092-uftc8inx 13133 16 for for IN cord-010092-uftc8inx 13133 17 HLA HLA NNP cord-010092-uftc8inx 13133 18 - - HYPH cord-010092-uftc8inx 13133 19 A A NNP cord-010092-uftc8inx 13133 20 , , , cord-010092-uftc8inx 13133 21 95.7 95.7 CD cord-010092-uftc8inx 13133 22 % % NN cord-010092-uftc8inx 13133 23 for for IN cord-010092-uftc8inx 13133 24 HLA HLA NNP cord-010092-uftc8inx 13133 25 - - HYPH cord-010092-uftc8inx 13133 26 B B NNP cord-010092-uftc8inx 13133 27 , , , cord-010092-uftc8inx 13133 28 100 100 CD cord-010092-uftc8inx 13133 29 % % NN cord-010092-uftc8inx 13133 30 for for IN cord-010092-uftc8inx 13133 31 HLA HLA NNP cord-010092-uftc8inx 13133 32 - - HYPH cord-010092-uftc8inx 13133 33 C. C. NNP cord-010092-uftc8inx 13133 34 Summary Summary NNP cord-010092-uftc8inx 13133 35 / / SYM cord-010092-uftc8inx 13133 36 Conclusions Conclusions NNPS cord-010092-uftc8inx 13133 37 : : : cord-010092-uftc8inx 13134 1 The the DT cord-010092-uftc8inx 13134 2 full full JJ cord-010092-uftc8inx 13134 3 - - HYPH cord-010092-uftc8inx 13134 4 length length NN cord-010092-uftc8inx 13134 5 precision precision NN cord-010092-uftc8inx 13134 6 sequencing sequencing NN cord-010092-uftc8inx 13134 7 platform platform NN cord-010092-uftc8inx 13134 8 for for IN cord-010092-uftc8inx 13134 9 HLA HLA NNP cord-010092-uftc8inx 13134 10 - - HYPH cord-010092-uftc8inx 13134 11 I i NN cord-010092-uftc8inx 13134 12 gene gene NN cord-010092-uftc8inx 13134 13 ( ( -LRB- cord-010092-uftc8inx 13134 14 HLA HLA NNP cord-010092-uftc8inx 13134 15 - - HYPH cord-010092-uftc8inx 13134 16 A A NNP cord-010092-uftc8inx 13134 17 , , , cord-010092-uftc8inx 13134 18 -B -b ADD cord-010092-uftc8inx 13134 19 , , , cord-010092-uftc8inx 13134 20 -C -c ADD cord-010092-uftc8inx 13134 21 ) ) -RRB- cord-010092-uftc8inx 13134 22 based base VBN cord-010092-uftc8inx 13134 23 on on IN cord-010092-uftc8inx 13134 24 NGS NGS NNP cord-010092-uftc8inx 13134 25 technology technology NN cord-010092-uftc8inx 13134 26 was be VBD cord-010092-uftc8inx 13134 27 established establish VBN cord-010092-uftc8inx 13134 28 , , , cord-010092-uftc8inx 13134 29 which which WDT cord-010092-uftc8inx 13134 30 could could MD cord-010092-uftc8inx 13134 31 greatly greatly RB cord-010092-uftc8inx 13134 32 reduce reduce VB cord-010092-uftc8inx 13134 33 the the DT cord-010092-uftc8inx 13134 34 probability probability NN cord-010092-uftc8inx 13134 35 of of IN cord-010092-uftc8inx 13134 36 ambiguous ambiguous JJ cord-010092-uftc8inx 13134 37 results result NNS cord-010092-uftc8inx 13134 38 and and CC cord-010092-uftc8inx 13134 39 effectively effectively RB cord-010092-uftc8inx 13134 40 improve improve VB cord-010092-uftc8inx 13134 41 the the DT cord-010092-uftc8inx 13134 42 accuracy accuracy NN cord-010092-uftc8inx 13134 43 of of IN cord-010092-uftc8inx 13134 44 existing exist VBG cord-010092-uftc8inx 13134 45 HLA HLA NNP cord-010092-uftc8inx 13134 46 typing typing NN cord-010092-uftc8inx 13134 47 techniques technique NNS cord-010092-uftc8inx 13134 48 . . . cord-010092-uftc8inx 13134 49 _SP